gebhart/patrepeval huggingface dataset:
A Thermoresponsive Biodegradable Polymer with Intrinsic Antioxidant Properties (2014)

Oxidative stress in tissue can contribute to chronic inflammation that impairs wound healing and the efficacy of cell-based therapies and medical devices. We describe the synthesis and characterization of a biodegradable, thermoresponsive gel with intrinsic antioxidant properties suitable for the delivery of therapeutics. Citric acid, poly(ethylene glycol) (PEG), and poly-N-isopropylacrylamide (PNIPAAm) were copolymerized by sequential polycondensation and radical polymerization to produce poly(polyethylene glycol citrate-co-N-isopropylacrylamide) (PPCN). PPCN was chemically characterized, and the thermoresponsive behavior, antioxidant properties, morphology, potential for protein and cell delivery, and tissue compatibility in vivo were evaluated. The PPCN gel has a lower critical solution temperature (LCST) of 26 °C and exhibits intrinsic antioxidant properties based on its ability to scavenge free radicals, chelate metal ions, and inhibit lipid peroxidation. PPCN displays a hierarchical architecture of micropores and nanofibers, and contrary to typical thermoresponsive polymers, such as PNIPAAm, PPCN gel maintains its volume upon formation. PPCN efficiently entrapped and slowly released the chemokine SDF-1α and supported the viability and proliferation of vascular cells. Subcutaneous injections in rats showed that PPCN gels are resorbed over time and new connective tissue formation takes place without signs of significant inflammation. Ultimately, this intrinsically antioxidant, biodegradable, thermoresponsive gel could potentially be used as an injectable biomaterial for applications where oxidative stress in tissue is a concern.
Processing, characteristics and properties of CNT-enhanced PA 66. (2017)

In this research, structure-properties-processing relationships of melt-processed CNT-PA 66 composites are investigated. Using a novel high-shear mixing device, efficient dispersal of CNTs in molten PA 66 is achieved, forming a well-bonded composite that displays enhanced mechanical properties. Post-fabrication heat treatment of some graphite-polymer composites also changes properties in new and unexpected ways. Observations by SEM and TEM indicate good bonding between CNTs and PA 66. DSC measurements show a second crystallization peak in the cooling curve, as the CNT content in PA 66 matrix increases from 1 to 5 wt. %. This new type of crystallization becomes a dominant feature in the range of 6-8 wt. % CNTs. Such interactions correlate with changes in elastic modulus and impact strength. FTIR analysis shows a steady increase in peak intensities for 1-5 wt. % CNT-PA 66 composites, until at 6 wt. % there is a sudden decrease in Amide I and II stretching peak intensities, accompanied by a shift to lower wave numbers. This behavior may be attributed to transformation of the original matrix structure to a new C-C rich bonded crystalline state. Three-point bend tests show a decrease in elastic modulus up to 3 wt. % CNTs in PA 66 due to minor degradation of the polymer matrix. At higher CNT concentrations, covalent bonding between fractured-ends of CNTs and polymer matrix occurs, which increases elastic modulus via a load transfer mechanism. At even higher CNT concentrations, a bridging effect occurs between adjacent covalently-bonded regions that increases impact strength. Eventually this results in a fully cross-linked structure of high stiffness and low impact resistance. As might be expected, peak stress at fracture shows an inverse relationship with stiffness. A two-step heat treatment is used to modify the structure and properties of 35 wt. % graphite-PEEK composite. It involves heating the composite at 200°C for 20 hours and then at 380°C for 18 hours. Examination of samples by TEM and XPS showed some polymer has gasified and the remaining polymer is a well-crystallized PEEK. 35 wt. % graphite-PA 66 composite was heat treated at 280°C for 24 and 48 hours. A new highly crystalline phase led to increase in elastic modulus was investigated by DSC and FTIR. This opens new opportunities to enhance properties and performance of injection-molded components or parts.
Optimized Verifiable Fine-Grained Keyword Search in Dynamic Multi-owner Settings (2019)

Ciphertext-Policy Attribute-Based Keyword Search (CP-ABKS) schemes support both fine-grained access control and keyword-based ciphertext retrieval, which make these schemes attractive for resource-constrained users (i.e., mobile or wearable devices, sensor nodes, etc.) to store, share and search encrypted data in the public cloud. However, ciphertext length and decryption overhead in the existing CP-ABKS schemes grow with the complexity of access policies or the number of data users' attributes. Moreover, such schemes generally do not consider the practical multi-owner setting (e.g., each file needs to be signed by multiple data owners before being uploaded to the cloud server) or prevent malicious cloud servers from returning incorrect search results. To overcome these limitations, in this paper we first design an optimized Verifiable Fine-grained Keyword Search scheme in the static Multi-owner setting (termed as basic VFKSM), which achieves short ciphertext length, fast ciphertext transformation, accelerated search process, and authentic search result verification. Then, we extend the basic VFKSM to support multi-keyword search and multi-owner update (also called as extended VFKSM). Finally, we prove that the basic (or extended) VFKSM resists the Chosen-Keyword Attack (CKA) and external Keyword-Guessing Attack (KGA). We also evaluate the performance of these schemes using various public datasets.
Significant Determinants of Mouse Pain Behaviour (2014)

Transgenic mouse behavioural analysis has furthered our understanding of the molecular and cellular mechanisms underlying damage sensing and pain. However, it is not unusual for conflicting data on the pain phenotypes of knockout mice to be generated by reputable groups. Here we focus on some technical aspects of measuring mouse pain behaviour that are often overlooked, which may help explain discrepancies in the pain literature. We examined touch perception using von Frey hairs and mechanical pain thresholds using the Randall-Selitto test. Thermal pain thresholds were measured using the Hargreaves apparatus and a thermal place preference test. Sodium channel Nav1.7 knockout mice show a mechanical deficit in the hairy skin, but not the paw, whilst shaving the abdominal hair abolished this phenotype. Nav1.7, Nav1.8 and Nav1.9 knockout mice show deficits in noxious mechanosensation in the tail, but not the paw. TRPA1 knockout mice, however, have a loss of noxious mechanosensation in the paw but not the tail. Studies of heat and cold sensitivity also show variability depending on the intensity of the stimulus. Deleting Nav1.7, Nav1.8 or Nav1.9 in Nav1.8-positive sensory neurons attenuates responses to slow noxious heat ramps, whilst responses to fast noxious heat ramps are only reduced when Nav1.7 is lost in large diameter sensory neurons. Deleting Nav1.7 from all sensory neurons attenuates responses to noxious cooling but not extreme cold. Finally, circadian rhythms dramatically influence behavioural outcome measures such as von Frey responses, which change by 80% over the day. These observations demonstrate that fully characterising the phenotype of a transgenic mouse strain requires a range of behavioural pain models. Failure to conduct behavioural tests at different anatomical locations, stimulus intensities, and at different points in the circadian cycle may lead to a pain behavioural phenotype being misinterpreted, or missed altogether.
Bis(µ-diphenylphosphido-µ′-carbonyl-π-methylcyclopentadienyl-carbonyliron)-rhodium hexafluorophosphate: a non-closed trinuclear rhodium–iron complex (1972)

The reaction of [Rh(C8H12)Cl]2, [Rh(CO)2Cl]2, or RhCl3,3H2O in methanol or [Rh(C8H12)(thf)2]+ in tetrahydrofuran with an excess of [Fe(PPh2)(CO)2(π-C5H4Me)] in the presence of PF6– affords the title compound; an X-ray diffraction analysis shows the metals to be in a non-clustered configuration.
Sediment Transport Modeling for the Glen-Colusa Irrigation District Fish Screen Modifications (1996)

The Glen-Colusa Irrigation District (GCID) pumping plant is located on an oxbow of the Sacramento River approximately 100 miles north of Sacramento (Figure 1). The existing fish screen facilities do not meet current regulatory requirements and contribute to increased fish mortality. Fish in the intake channel may be subject to predation, and smaller fish may be impinged on the screens. The Bureau of Reclamation (Reclamation) was authorized to provide feasibility and final design work for the replacement of the fish screen. The facilities designed by Reclamation will allow GCm to operate the pumping plant at or near its full capacity of 3000 ft³/s. Sediment management issues were an important consideration in the design and location of the fish screen facilities. GCID dredges the intake channel and area in front of the existing screens following winter and spring runoff. Sediment buildup in front of the screens can exceed 3 ft. annually and can exceed 9 ft. at the intake channel entrance.
A self-adjuvanted nanoparticle based vaccine against infectious bronchitis virus (2018)

Infectious bronchitis virus (IBV) affects poultry respiratory, renal and reproductive systems. Currently the efficacy of available live attenuated or killed vaccines against IBV has been challenged. We designed a novel IBV vaccine alternative using a highly innovative platform called Self-Assembling Protein Nanoparticle (SAPN). In this vaccine, B cell epitopes derived from the second heptad repeat (HR2) region of IBV spike proteins were repetitively presented in its native trimeric conformation. In addition, flagellin was co-displayed in the SAPN to achieve a self-adjuvanted effect. Three groups of chickens were immunized at four weeks of age with the vaccine prototype, IBV-Flagellin-SAPN, a negative-control construct Flagellin-SAPN or a buffer control. The immunized chickens were challenged with 5x10(4.7) EID50 IBV M41 strain. High antibody responses were detected in chickens immunized with IBV-Flagellin-SAPN. In ex vivo proliferation tests, peripheral mononuclear cells (PBMCs) derived from IBV-Flagellin-SAPN immunized chickens had a significantly higher stimulation index than that of PBMCs from chickens receiving Flagellin-SAPN. Chickens immunized with IBV-Flagellin-SAPN had a significant reduction of tracheal virus shedding and lesser tracheal lesion scores than did negative control chickens. The data demonstrated that the IBV-Flagellin-SAPN holds promise as a vaccine for IBV.
Assessing Dynamic Reservoir Behavior with Time-Lapse Pre-Stack 3D Seismic Data - a Sensitivity Study Based on Inversion (2002)

P317 ASSESSING DYNAMIC RESERVOIR BEHAVIOR WITH TIME-LAPSE PRE-STACK 3D SEISMIC DATA - A SENSITIVITY STUDY BASED ON INVERSION O.J. VARELA C. TORRES-VERDÍN M.K. SEN and I.G. ROY Abstract 1 We carry out an inversion study to appraise the ability of time-lapse 3D seismic data to infer spatial distributions of petrophysical properties. Synthetic seismic models are constructed from the output of multi-phase fluid flow simulators of spatially heterogeneous reservoirs. We consider the inversion of post- and pre-stack 3D seismic data to infer space-time distributions of petrophysical variables within the reservoir. Our sensitivity study is strictly based on inversion and hence sheds
The Comparison of Corneal Ablation Amount by MEL-60 Excimer Laser and Schwind Multiscan Excimer Laser Systems. (2003)

Purpose: The expected corneal ablation amount was compared to the achieved corneal ablation amount in two different excimer laser systems. Methods: One hundred twenty eyes were recieved Laser In Situ Keratomileusis (LASIK) for the correction of myopia. LASIK was performed with MEL-60 excimer laser and Schwind Multiscan excimer laser system. The central corneal thickness was measured preoperatively, 1 week and 1 month postoperatively by using ultrasonic pachymetry, Results: In eyes with MEL-60 excimer laser, the average expected corneal ablation amount was 81 26. and average achieved corneal ablation amount at postoperative one week was 6526 . There was statistical difference between expected and achieved ablation amount. (p 25 and average achieved corneal ablation amount at postoperative one week was 6925 .. There was no statistical difference between expected and achieved ablation amount (p=0.761, paired samples test). Conclusions: The pachymetry at postoperative one week appears to be an useful method to measure the real corneal ablation amount by LASIK with various excimer lasers. Residual stromal bed thickness after LASIK can be presumed, and it helps to decide modality of retreatment.
Masked ion beam lithography and direct structuring on curved surfaces (2003)

We have previously demonstrated (Proc. SPIE Vol. 4688, 595, 2002; JM3 Vol. 2, Nr. 1, 34, 2003) a depth of focus of several millimeters in masked ion beam lithography (MIBL). This work illustrates the use of this capability to pattern concave and convex spherical substrates 25 mm in diameter and 5.5 mm deep. Features as small as 175nm were printed across a convex substrate with 75 keV He<sup>+</sup> ions where the mask-to-wafer gap varied from 1 mm on the center to 6.5 mm on the edge. We also demonstrate, for the first time, the fabrication of 800 nm features in a 4 nm thick Cr coating by masked ion beam direct structuring (MIBS), where 45 keV Argon ions sputter the film through a stencil mask. We demonstrate electronic adjustment of the radial beam profile of the incident ion beam to compensate for the continuously changing angle between the beam and the spherical substrate, thus achieving constant exposure dose (for MIBL) or sputtering rate (for MIBS) a 50 &times; 50 mm<sup>2</sup> field.
Estudo do perfil da expressão genica global em leucemias linfoides agudas de linhagens de celulas B e T (2004)

A compreensao das informacoes geradas pelos diversos Projetos Genoma ja totalizados ou em andamento constitui-se em uma ferramenta essencial a pesquisa em biologia molecular. A identificacao de genes diferencialmente expressos em estagios distintos de uma dada doenca, por exemplo, constituira um enorme avanco na determinacao de sua fisiopatologia, fornecendo marcadores moleculares para seu prognostico e possiveis alvos para a intervencao do processo. Dentre as molestias humanas, o câncer constitui-se em um dos principais alvos de pesquisa em biologia molecular e clinica medica, basicamente porque envolve um quadro de reprogramacao celular complexo e ainda pouco
compreendido. Entre os varios tipos de cânceres, a leucemia linfoide aguda e bastante prevalente no Brasil, classificando-a como 8° lugar em numero de casos e obitos decorrentes. Buscando compreender as bases moleculares do câncer, o Projeto Genoma Humano do Câncer (LICR/ FAPESP) se destacou por ter gerado milhares de sequencias codantes do DNA de tecidos humanos normais e tumorais, possibilitando a descoberta de novos genes relacionados aos processos carcinogenicos. Assim, o presente estudo utilizou fragmentos produzidos durante o Projeto Genoma Humano do Câncer para investigar o perfil de expressao genica em leucemias linfoides agudas atraves da tecnica de microarranjos de DNA.
Foram identificados como diferencialmente expressos os genes IgK VLJ (immunoglobulin kappa light chain VLJ region) e TPT1 (Tumor Protein , translationally-controlled 1), cuja expressao foi confirmada por ensaios de Northern blot. 
Abstract
Mass Spectrometric Studies of Reductive Elimination from Pd(IV) Complexes (2013)

Reductive elimination of ethane from the palladium(IV) complex [PdMe3(bpy)I] (bpy = 2,2'-bipyridine) is studied by electrospray ionization mass spectrometry. Palladium(IV) complexes can be detected as binuclear clusters [Pd2Me6I(bpy)2](+) or as complexes [PdMe3(bpy)(L)](+) stabilized by an electron-donating ligand L. Fragmentation of all palladium(IV) complexes is dominated by elimination of ethane which corresponds to the reductive elimination coupling of the methyl groups. The associated energy demands for different complexes reveal that the mononuclear complexes with poorly electron-donating ligands provide the fastest reaction.
A Study of Two-Phase, Non-Darcy Gas Flow Through Proppant Pacs (2000)

Summary Through a systematic experimental study it is found that the effect of liquid phase on non-Darcy gas flow through proppant packs cannot be characterized by Forchheimer correlation alone. An empirical equation that uses liquid-to-gas ratio to predict the effective permeability or conductivity of a proppant pack under two-phase, non-Darcy flow conditions is proposed in the paper. The effective permeability of a proppant pack at different conditions can then be calculated taking both non-Darcy and two-phase flow effect into account. A simplified physical model is developed to calculate a mobile liquid saturation at two-phase flow conditions.
Initial study of heterogeneous catalysts behaviour and carrier gas permeation with catalytic inorganic ceramic membrane for lactic acid esterification applications. (2015)

Inorganic membranes continue to attract a lot of attention in various fields including industry and academia, due to the great potential they have shown in various applications. Recently, some studies have focused on the water -permeable metallic membrane reactor involving liquid-phase reversible reactions including esterification reactions. Among the membranes considered, inorganic membrane have been found to be the perfect membrane for the esterification reaction process because they can allow heterogeneous catalysts to be deposited easily on the surface of the membrane; this results in increase in the yield of products. The use of inorganic ceramic to selectively eliminate water from the reaction product during esterification of lactic acid is yet another important application that has attracted a lot of attention. In this work, the initial study of heterogeneous catalyst behaviour and carrier gas permeation with inorganic ceramic membrane for lactic acid esterification applications was carried out. Dowex 50W8x, Amberlyst 36, Amberlyst 15 and Amberlyst 16 cation-exchange resins were used as heterogeneous catalysts. The SEM/EDXA of the resin catalyst was investigated in order to determine the surface morphology of the resin. The EDXA of the catalysts showed the presence of sulphur which confirms the sulfonic acid group in the structure of the polymeric compound. The permeation properties of inorganic ceramic membrane with the carrier gases were also analysed between the gauge pressures of 0.01-1.00 bar at the temperature of 60oC (333 K). The membrane was coated twice using silica solution before the permeation experiments. The carrier gas permeance of the silica membrane showed a linear dependence on the inverse square root of the gas molecular weight indicating Knudsen mechanism of transport. Gases with highest viscosity value exhibited the least permeance indicating viscous flow contribution. It was concluded that Knudsen and viscous mechanisms plays a major role in the carrier gas permeation with inorganic ceramic membrane.
Field Tests of the Vertical-Array Differential Target Antenna Coupling (DTAC) System (2017)

ABSTRACT We have tested the Vertical-Array Differential Target Antenna Coupling (DTAC) system over a variety of well-characterized, buried targets. The DTAC system produces a primary field in the frequency range of 10 Hz to 10 kHz and records secondary magnetic fields from subsurface targets, relative to a reference frequency. The current DTAC system has higher power, compared with our earlier tests, and this system is suitable for either ground or airborne mapping of a wide variety of near-surface targets, which might be encountered in civil engineering, water resources, environmental characterization, mining, and other natural-resource exploration. Profiles over three well-characterized targets show a close agreement between the measured DTAC response and model simulations. Conventional field measurements using induced magnetic fields are also displayed and they do not show nearly as effective mapping of the targets. Another profile shows that the DTAC method has greatly reduced sensitivity to surface clutter, compared to conventional measurements.
Safety and efficacy of immune checkpoint inhibitors in advanced urological cancers with pre-existing autoimmune disorders: a retrospective international multicenter study (2020)

Patients with RCC and UC with well-controlled AD can benefit from CPI with manageable toxicities that are consistent with what is expected of a non-AD population. Prospective study is warranted to comprehensively evaluate the benefits and safety of CPI in patients with AD.
Meßmethoden und Kenngrößen zur Ermittlung des Arbeitserfolges beim Pflügen (1968)

Durch das Pflugen werden physikalische, biologische und chemische Veranderungen des Bodens eingeleitet, die sowohl das Pflanzenwachstum wahrend einer Vegetationsperiode als auch den Status der Bodenfruchtbarkeit auf langere Sicht beeinflussen. Diese Einflu?Ynahme geschieht mittels der beim Pflugen unmittelbar auftretenden Effekte des Wendens, Lockerns, Krumelns und des (unerheblichen) Mischens, aber auch durch die Gestaltung der Bodenoberflache und ganz allgemein durch den Transport des Bodens. Fur die Messung dieser ?EURzSofort-Effekte wurden Methoden und Gerate entwickelt. In mehrjahrigen Feldversuchen wurden auf drei Bodenarten, fur je drei Arbeitstiefen und Fahrgeschwindigkeiten Me?Ywerte ermittelt, welche fur die sechs untersuchten typischen Pflugkorper zahlenma?Yige Angaben uber den Arbeitserfolg erlauben. Es wird gezeigt, wie der Arbeitserfolg von Pflugkorpern anhand von Zahlenwerten verglichen werden kann, sofern die Definition des Bodens, die Geschwindigkeit und das Breiten- Tiefen- Verhaltnis des Furchenquerschnittes einheitlich gehandhabt werden. Au?Yerdem wird zur optimalen Geschwindigkeit, zur Breite des Schlepperreifens in der Furche und zum Zugkraftbedarf der Pflugkorper Stellung genommen.
Peripheral neuroendocrinology of the cervical autonomic nervous system. (1994)

1. The sympathetic superior cervical ganglia (SCG) provide innervation to the pineal gland and median eminence through the internal carotid nerve and to the thyroid and parathyroid glands through the external carotid nerve. 2. Postsynaptic activation in median eminence nerve endings shortly after superior cervical ganglionectomy (SCGx) was accompanied by a depression of LH and FSH release and by a 3-5 day delay in rat estrous cyclicity. A decrease in TSH and GH release and an increase in ACTH and prolactin release were also found. These effects were accompanied by a) an increase in medial basal hypothalamic (MBH) LHRH, TRH and GHRH, b) a decrease in MBH somatostatin, AVP and CRH, and c) a normal adenohypophyseal response to hypophysiotropic hormones. Neurohypophyseal AVP release decreased during degeneration of sympathetic nerve terminals in the neurohypophyseal lobe after SCGx. The effects were generally mediated by alpha 1-adrenoceptors and were pineal gland. 3. In thyroid and parathyroid tissue the following events were observed during the wallerian degeneration phase after SCGx: a) alpha 1-adrenoceptor inhibition of thyroxine (T4) release, b) alpha 1-adrenoceptor inhibition, together with beta-adrenoceptor stimulation, of calcitonin release, and c) alpha 1-adrenoceptor inhibition of parathyroid hormone release. Thyroid sympathetic nerves also modulate slow phenomena such as compensatory thyroid growth after partial thyroidectomy. 4. In rats subjected to cholinergic decentralization of the thyroid gland, a decrease of plasma T4 and an increase of plasma TSH, as well as an impaired goitrogenic and thyroid compensatory response were detectable. The calcitonin and PTH response to changes in calcium levels increased after regional parasympathetic denervation. 5. The results indicate that cervical autonomic nerves constitute a parallel pathway through which the brain communicates with the endocrine system.