gebhart/patrepeval huggingface dataset:
A Facile Synthesis of Highly Functionalized Unsymmetrical Heterobiaryls Utilizing the Intramolecular Ullmann Coupling Reaction Directed by Salicyl Alcohol as a Template (1992)

m -H e t e m b i a r y l s (4) were synthesized in good yields utilizing the inuamolecular Ullmann coupling reaction directed by salicyl alcohol as a template.The regioselective cleavage of the two ester bonds of 4 gave the highly functionalized unsymmetrical hetembiaryls having suhstituents which are incompatible with organometallic reagentsThe highly functionalized unsymmehical heterobiaryls are of considerable interest recently as useful intermediates in the synthesis of biologically active natural products such as tanshinone.]The synthetic methods of heterobiaryls so far reported include those based on the transition metal-catalyzed cross coupling reaction of an aryl metal with an aryl halide and the intermolecuar Ullmann coupling reaction.2.3However, difficulties are frequently encountered in the transition metal-catalyzed cross coupling reactions between two aryls having subsituents which are incompatible with the organometallic reagents.On the other hand, the intermolecular Ullmann coupling reaction gives rise to the undesired symmemcal biiuyls.We recently reported that the templatedirected inuamolecular Ullmann coupling reaction is quite effective in the synthesis of a variety of diphenic acid derivatives4 In connection with our synthetic studies in search of new compounds having intriguing biological activities,5 we now report a facile synthesis of highly functionalized unsymmetrical heterobiaryls utilizing the intramolecular Ullmann coupling reaction directed by salicyl alcohol as a template, followed by regioselective cleavage of the two ester bonds of 4.-
An evaluation of neural network ensembles and model selection for time series prediction (2010)

Ensemble methods represent an approach to combine a set of models, each capable of solving a given task, but which together produce a composite global model whose accuracy and robustness exceeds that of the individual models. Ensembles of neural networks have traditionally been applied to machine learning and pattern recognition but more recently have been applied to forecasting of time series data. Several methods have been developed to produce neural network ensembles ranging from taking a simple average of individual model outputs to more complex methods such as bagging and boosting. Which ensemble method is best; what factors affect ensemble performance, under what data conditions are ensembles most useful and when is it beneficial to use ensembles over model selection are a few questions which remain unanswered. In this paper we present some initial findings using neural network ensembles based on the mean and median applied to forecast synthetic time series data. We vary factors such as the number of models included in the ensemble and how the models are selected, whether randomly or based on performance. We compare the performance of different ensembles to model selection and present the results.
Rewarming of the hypothermic rhesus monkey with electromagnetic radiation (1987)

To obtain more detailed information relative to the potential usefulness of using radio frequency (RF) energy in treating hypothermia, anesthetized rhesus monkeys were used in a rewarming study that compared a conventional method (heating pad) with an RF induction coil system. Rectal temperature (Tre) of each subject was monitored, and enzyme and isoenzyme levels were determined from blood samples collected before, during, and up to 48 h after hypothermia in order to assess the effects of each rewarming method. The previously observed postprocedure rise in serum enzymes (most visible at 24 h) was again seen, with no statistically significant difference in the time course of serum enzyme levels between the two treatments for comparable durations of hypothermia. To test the limits of the ability of the RF induction coil system, successively more severe hypothermia was induced in the subjects to the point of cardiovascular collapse (Tre less than 20 degrees C); RF energy was successful in resuscitating the profoundly hypothermic subjects without discernible harmful effects.
Abstract 2483: No Increased Risk of sICH in tPA Treated Stroke Patients With ECASS Exclusion Criteria (2012)

Introduction: Only about 2% of ischemic stroke patients are currently treated with IV tPA, with the most common reason for exclusion from treatment being time. The positive results of ECASS III expanded the time window for treatment to 4.5 hours, however it used more stringent exclusion criteria than are in use for &lt;3 hrs in the USA. For patients who present 3-4.5 hours from symptom onset, the scientific advisory from the AHA/ASA recommends use of the more narrow ECASS III criteria. We evaluated the outcomes of patients who had been treated with IV tPA to test the hypothesis that thrombolysis is not safe in patients with one of the additional exclusion criteria (age &gt;80, NIHSS &gt;25, combination of previous stroke and diabetes, aggressive measures required to control blood pressure (IV infusion), or oral anticoagulant treatment). Methods: We performed a retrospective analysis of all acute ischemic stroke patients treated with IV tPA at our tertiary care academic medical center between June 2006 and June 2010. 191 patients were identified and stratified based on presence of each of the listed exclusion criteria. The primary outcomes are rate of symptomatic intracerebral hemorrhage (sICH) and in-hospital mortality. Additionally, patients with and without sICH were analyzed for differences in baseline characteristics. Results: There were 31 patients older than 80 years, 5 with NIHSS &gt;25, 14 with the combination of prior stroke and diabetes, 19 required continuous IV infusions to control blood pressure below 185/110 mmHg, and 11 were taking oral anticoagulants. No exclusion criterion was associated with increased risk of sICH. There was higher in hospital mortality in patients &gt;80 years (5 of 31 (16%) vs. 6 of 160 (4%), p=0.0186, RR = 3.15, 95% CI: 1.50 to 6.59), and those with NIHSS &gt;25 (2 of 5 (40%) vs. 7 of 159 (4.4%), Relative risk = 11.48, 95% CI: 2.19 to 60.30). sICH was associated with atrial fibrillation (5 of 9 (55%), vs. 35 of 182 (19.2%), p=0.021; RR = 4.72, 95% CI: 1.33 to 16.77), larger final infarct volume (mean 173 ml 3 (SEM 43.3) vs. 42 ml 3 (SEM 6.3),p=0.0002), and elevated glucose (mean 166 mg/dL (SEM 23.1) vs. 127 mg/dL (SEM 4.1), p=0.038). Conclusions: In our cohort, none of the exclusion criteria from ECASS III, which were more stringent than those used in 0-3 hour US labeling, were associated with increased risk of sICH. tPA may be safe in these patients, who represent an important patient population of acute stroke patients. In agreement with prior studies, we have found that older patients and those with more severe deficits at presentation have higher mortality after acute ischemic stroke. Prospective studies are urgently needed to determine the safety and efficacy of tPA in this group of patients through all treatment time windows.
Investigation on the electrical, thermal and mechanical properties of silicone rubber nanocomposites (2019)

Addition of alumina nano particles to silicone rubber (SR) has shown a significant improvement in electrical, mechanical and thermal properties of the SR nanocomposites. Static contact angle and water droplet-initiated corona inception voltage exhibited a marginal change on inclusion of nano alumina into SR matrix. Alumina filler improved the corona ageing resistance of the composites; however, a marginal reduction in the rate of hydrophobicity recovery is observed. Laser induced breakdown spectroscopy proved as an effective tool to rank the performance of the SR nano composites. Variation of crater depth with energy of laser pulse and number of laser pulses follows the exponential relation. Plasma temperature calculated by optical emission spectroscopy is in line with the amount of damage caused to the surface of the specimen by water droplet-initiated discharge. Dielectric response spectroscopic studies indicate that inclusion of nano fillers has resulted in lower interfacial polarization and lower imaginary permittivity. It is observed through dynamic mechanical analysis that the composites have higher storage modulus and the activation energy compared to base SR.
Display-dependent dynamic bit-streaming of waveletcompressed data for image retrieval systems (1998)

The authors propose a low complexity scheme for generating multiple bit-streams, each optimised for a different display resolution, from a single bit-stream stored in the image retrieval database. Simulation results show that the proposed scheme outperforms the single bit-stream case significantly in terms of progression speed and bit-stream size.
Mass Number Dependence of the Forward Production of Charged Hadrons and Nuclear Fragments in Carbon–Lead and Carbon–Carbon Interaction at a Beam Energy of 19.6 GeV per Nucleon (2021)

The inclusive differential cross sections for the production of $$\pi^{\pm}$$ and $$k^{-}$$ mesons, protons, and antiprotons with momenta between 6 and 50 GeV/c and nuclear fragments of mass number $$1\leq A\leq 10$$ in the momentum range between 20 and 220 GeV/c were measured in carbon–lead collisions at a beam kinetic energy of 19.6 GeV per nucleon ( $$\sqrt{S_{NN}}=6.3$$ GeV). A comparison with the respective cross sections for carbon–carbon interactions is performed, and the dependence on the target mass number ( $$A$$ ) is estimated. The present analysis shows that the observed particles originate predominantly from peripheral interactions.
Safety of the use of gold nanoparticles conjugated with proinsulin peptide and administered by hollow microneedles as an immunotherapy in type 1 diabetes (2022)

Antigen-specific immunotherapy is an immunomodulatory strategy for autoimmune diseases, such as type 1 diabetes, in which patients are treated with autoantigens to promote immune tolerance, stop autoimmune β-cell destruction and prevent permanent dependence on exogenous insulin. In this study, human proinsulin peptide C19-A3 (known for its positive safety profile) was conjugated to ultrasmall gold nanoparticles (GNPs), an attractive drug delivery platform due to the potential anti-inflammatory properties of gold. We hypothesised that microneedle intradermal delivery of C19-A3 GNP may improve peptide pharmacokinetics and induce tolerogenic immunomodulation and proceeded to evaluate its safety and feasibility in a first-in-human trial. Allowing for the limitation of the small number of participants, intradermal administration of C19-A3 GNP appears safe and well tolerated in participants with type 1 diabetes. The associated prolonged skin retention of C19-A3 GNP after intradermal administration offers a number of possibilities to enhance its tolerogenic potential, which should be explored in future studies.
La periferia en transformación... Procesos de cualificación del espacio público (2018)

Master Oficial en Disseny Urba: Art, Ciutat, Societat. Facultat de Belles Arts de la UB, curs: 2017-2018, Tutor: Jose Antonio Santamaria Concha
Molecular testing and patterns of treatment in patients with NSCLC: An IASLC analysis of ASCO CancerLinQ Discovery Data. (2022)

9128 Background: Precision medicine has resulted in improved outcomes for non-small cell lung cancer (NSCLC); while molecular testing is considered critical for guiding treatment decisions for advanced stage NSCLC, adoption of testing in routine practice is variable. We analyzed the factors contributing to molecular testing and treatment patterns in patients with lung cancer. Methods: The ASCO CancerLinQ Discovery dataset was queried to identify patients diagnosed with lung cancer between the years 2010-2018. Data on demographics, tumor stage, histology and treatments were extracted, and receipt of molecular testing was investigated as the primary outcome. Univariate association of each clinicopathological variable with molecular testing outcome was performed using chi-square test for categorical variables and ANOVA test for numerical variables. A multivariable logistic regression analysis with backward selection at an alpha of 0.05 was reported. All analyses were conducted using SAS 9.4. Results: A total of 37,925 NSCLC patients with stage IV disease were analyzed. Patient characteristics: median age 65 years, 51% male, 68% white, 33.5% adenocarcinoma. Approximately 22% of all NSCLC patients had molecular testing results. In adenocarcinoma patients, 49% had molecular testing results available. In the stage IV group, 47% were treated with chemotherapy, 16% with immunotherapy and 3% with targeted therapy. On multivariable analysis, females were more likely to have molecular testing compared to males [(OR: 1.29 (1.22-1.37); p &lt; 0.001]. Compared to White patients, Black patients were less likely to have molecular testing [OR: 0.89 (0.81-0.97); p = 0.009] and Asians were more likely to undergo testing [OR: 2.22 (1.79-2.75); p &lt; 0.001]. Hispanic patients were more likely to undergo molecular testing compared to non-Hispanics [OR:1.24 (1.02-1.52); p = 0.03]. Additionally, treatment with immunotherapy [OR: 1.86 (1.72-2.01); p &lt; 0.001] and targeted therapy [OR: 2.29 (2.00-2.64); p &lt; 0.001] were associated with significantly higher likelihood of having molecular testing. These results were also confirmed on a subgroup analysis of adenocarcinoma patients. Conclusions: In this analysis of a US-based real-world dataset of stage IV NSCLC patients, White race and female sex are associated with higher likelihood of having molecular test performed. The percentage of patients undergoing testing remains sub-optimal.
Extraction of photoluminescence with Pearson correlation coefficient from images of field-installed photovoltaic modules (2023)

Photoluminescence imaging of field-installed photovoltaic modules has the potential to be a high throughput on-site inspection technique. A contribution to this development is a noninvasive photoluminescence imaging method that has been proposed recently. It is based on acquiring images during a progressing current–voltage curve sweep, resulting in a detection of a continuously changing photoluminescence signal. From this follows the necessity to employ an alternative algorithm based on the Pearson correlation coefficient, which will contribute to efficient, unsupervised image processing and, thus, easier (in real-time) implementation. The new algorithm separates photoluminescence from the reflected sunlight, similar to the conventional subtraction algorithm. However, it is robust to varying solar irradiance and can process the photoluminescence signal emitted from multiple asynchronized strings. We predict that it will enable unsupervised real-time surveillance and detection of functional anomalies at a low computational cost. It is also more sensitive at segmenting ground-reflected photoluminescence.
Examples of the estimation of the antenna gain in the millimeter wavebands (2015)

Loss evaluation is important in the link budget of the wireless system in the millimeter wavebands. In order to estimate the antenna gain reasonably, the loss factors of the antenna should be evaluated carefully. This report surveys the gains of the antennas, such as the standard horns, the waveguide slot arrays, the post-wall waveguide slot arrays and so on in the millimeter wavebands. As an example, the authors evaluate the loss factors of some typical kinds of antennas at 60 GHz. The estimated gains are plotted in different sizes.
Growth of a pure population of mouse mast cells in vitro with conditioned medium derived from concanavalin A-stimulated splenocytes. (1981)

A pure population of mast cells was obtained after 14 days of culturing mouse bone marrow cells in the presence of medium derived from concanavalin A-stimulated mouse spleen cells. The cells were characterized as mast cells by their morphologic appearance and histologic staining, by their histamine content (450 ng per 10(6) cells) and by the demonstration of IgE receptors on their surface (150,000--440,000 receptor sites per cell). The histamine content and the number of IgE receptors remained constant for at least 7 wk of culture. These mast cells could be passively sensitized to mice hybridoma IgE. They then released 43% of their histamine content upon incubation with anti-mouse hybridoma IgE.
Microscale hydrodynamic confinements: shaping liquids across length scales as a toolbox in life sciences (2022)

Hydrodynamic phenomena can be leveraged to confine a range of biological and chemical species without needing physical walls. In this review, we list methods for the generation and manipulation of microfluidic hydrodynamic confinements in free-flowing liquids and near surfaces, and elucidate the associated underlying theory and discuss their utility in the emerging area of open space microfluidics applied to life-sciences. Microscale hydrodynamic confinements are already starting to transform approaches in fundamental and applied life-sciences research from precise separation and sorting of individual cells, allowing localized bio-printing to multiplexing for clinical diagnosis. Through the choice of specific flow regimes and geometrical boundary conditions, hydrodynamic confinements can confine species across different length scales from small molecules to large cells, and thus be applied to a wide range of functionalities. We here provide practical examples and implementations for the formation of these confinements in different boundary conditions - within closed channels, in between parallel plates and in an open liquid volume. Further, to enable non-microfluidics researchers to apply hydrodynamic flow confinements in their work, we provide simplified instructions pertaining to their design and modelling, as well as to the formation of hydrodynamic flow confinements in the form of step-by-step tutorials and analytical toolbox software. This review is written with the idea to lower the barrier towards the use of hydrodynamic flow confinements in life sciences research.
Wireless Load Weight Monitoring Via a Mobile Device Based on Air Suspension Pressure (2012)

A system was designed and tested to measure pressure in the airbag suspension components of an over-the-road tractor trailer and use those signals to wirelessly display load weight. Three subcomponents (a HID -- human interface device and two DPUs -- digital processing units) were required and communicated using Zigbee wireless devices. Except for a region directly in front of the cab, the unit transmitted weights up to 45 m. Effect of number of calibration points on system accuracy was evaluated.
Achromatic Broadband Diffractive Lenses for Focusing and Imaging in LWIR (2019)

In contrast to conventional bulk optics, achromatic planar diffractive lenses operating in the LWIR (8um-12um) regime has been demonstrated in this work, which provides an efficient way for the development of compact, ultra-lightweight LWIR devices.
Sue My Car Not Me: Products Liability and Accidents Involving Autonomous Vehicles (2013)

Autonomous vehicles will revolutionize society in the near future. Computers, however, are not perfect, and accidents will occur while the vehicle is in autonomous mode. This Article answers the question of who should be liable when an accident is caused in autonomous mode. This Article addresses the liability of autonomous vehicle by examining products liability through the use of four scenarios: the Distracted Driver; the Diminished Capabilities Driver; the Disabled Driver; and the Attentive Driver.Based on those scenarios, this Article suggests that the autonomous technology manufacturer should be liable for accidents caused in autonomous mode because the autonomous vehicle probably caused the accident. Liability should shift back to the “driver” depending on the nature of the driver and the ability of that person to prevent the accident. Thus, this Article argues that an autonomous vehicle manufacturer should be liable for accidents caused in autonomous mode for the Disabled Driver and partially for the Diminished Capabilities Driver and the Distracted Driver. This Article argues the Attentive Driver should be liable for most accidents caused in autonomous vehicle. Currently, products liability does not currently allocate the financial responsibility of an accident to the party that is responsible the accident, and this Article suggests that courts and legislatures need to address tort liability for accidents caused in autonomous mode to ensure that the responsible party bears responsibility for accidents.
Photocatalytic degradation of pesticides by nanofibrous membranes fabricated by colloid-electrospinning (2020)

Photocatalytic degradation of organic pollutants is a promising way to clean wastewater. Herein, we develop and compare two processes for fabricating nanofibrous membranes with photocatalytic properties. Hybrid nanofibers are produced by colloid-electrospinning and composed of metal oxide nanoparticles on sintered SiO<sub>2</sub> nanoparticles. The latter serves as support for the photocatalyst and preserves the structural integrity of nanofibers. Adsorption of metal salts on crosslinked polymer/SiO<sub>2</sub> fibers followed by calcination allows for the obtention of fibers with large amounts of metal oxide. Nanofibrous membranes with supported ZnO, In<sub>2</sub>O<sub>3</sub>, or mixture of both, display photocatalytic activity upon UV irradiation. The membranes can degrade a dye and an organophosphate pesticide more effectively than membranes directly fabricated from the calcination of metal oxides.
PolicySupport,Norms,andSecondhandSmoke ExposureBeforeandAfterImplementationof aComprehensiveSmoke-FreeLawinMexicoCity (2010)

Objectives. We assessed attitudes and beliefs about smoke-free laws, compliance, and secondhand smoke exposure before and after implementation of a comprehensive smoke-free law in Mexico City. Methods. Trends and odds of change in attitudes and beliefs were analyzed across 3 representative surveys of Mexico City inhabitants: before implementation of the policy (n = 800), 4 months after implementation (n = 961), and 8 months after implementation (n = 761). Results. Results indicated high and increasing support for 100% smoke-free policies, although support did not increase for smoke-free bars. Agreement that such policies improved health and reinforced rights was high before policy implementation and increased thereafter. Social unacceptability of smoking increased substantially, although 25% of nonsmokers and 50% of smokers agreed with smokers’ rights to smoke in public places at the final survey wave. Secondhand smoke exposure declined generally as well as in venues covered by the law, although compliance was incomplete, especially in bars. Conclusions. Comprehensive smoke-free legislation in Mexico City has been relatively successful, with changes in perceptions and behavior consistent with those revealed by studies conducted in high-income countries. Normative changes may prime populations for additional tobacco control interventions. (Am J Public Health. 2010;100:1789–1798. doi:10.2105/AJPH.