gebhart/patrepeval huggingface dataset:
Hybrid HVDC converters and their impact on power system dynamic performance (2006)

Hybrid converter HVDC transmission is a new hybrid transmission system for connecting two AC systems. Because it uses different converters, this new configuration offers several advantages over conventional HVDC systems. This paper demonstrates the superior performance of hybrid converter based HVDC transmission systems with respect to increased stability and terminal AC voltage control. A control system is developed for the hybrid system and its dynamic performance is investigated. The hybrid system performance with emphasis on commutation failure during severe disturbances and its results is also compared with a conventional HVDC scheme
Brasiliquinones A, B and C, New Benz(a)anthraquinone Antibiotics from Nocardia brasiliensis. I. Producing Strain, Isolation and Biological Activities of the Antibiotics. (1997)

New benz[alpha]anthraquinone antibiotics (brasiliquinones A, B and C) with an ethyl group at C-3 were isolated. The producer was identified as Nocardia brasiliensis. The antibiotics were active against Gram-positive bacteria including Mycobacterium sp., but not active against Gram-negative bacteria or fungi. They were also active against multiple drug-resistant P388/ADR tumor cells.
Multidisciplinary Design Strategies for Turbomolecular Pumps With Ultrahigh Vacuum Performance (2019)

Turbomolecular pumps with ultrahigh vacuum performances are a desired technology among modern vacuum systems, which requires the pump to synchronously possess the wide pumping speed and high vacuum. This paper describes a systematic design methodology for a magnetically levitated turbomolecular pump with consideration of multiphysics constraints, such as the mechanical strength, rotor dynamics, electromagnetic losses, and thermal characteristic. These variables will directly decide the acquisition of high vacuum performances. The design process for such high-performance pumps requires multidisciplinary and highly iterative due to the complex interaction of the many design variables involved. The structure of the bladed rotor is determined in terms of the material selection and mechanical verification. In this paper, an effective modeling method is presented to achieve accurate bending modes of the bladed rotor. An assessment on the loss level and the thermal limit is performed to ensure the temperature rise of the pump within the acceptable range. The measured results show that the pump can achieve the high vacuum performance with the pumping speed of 4370 l/s and the lowest working pressure of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-8</sup> magnitude. The proposed design process described in this paper provides the general guidelines for the multidisciplinary design of high-performance turbomolecular pumps.
Auger electron spectroscopy of the hydrogen terminated chemical vapor deposited diamond surface (1996)

A simultaneous study of Auger spectra and secondary electron emission from the chemical vapor deposited diamond films under extended electron beam exposure is presented. Up to a 1.2 eV increase in energy of the carbon Auger peak accompanied by the decrease of the total secondary electron yield has been found. Exposure to hydrogen has resulted in recovery of the both Auger peak position and secondary yield. First-principles electronic structure calculations have shown that the effect is due to a change in the surface upper-valence band local density of states of the diamond crystal which is dependent on the extent of hydrogen coverage of the surface.
Antineoplastic 31-Norcycloartanones from Solanum cernuum Vell (2008)

Triterpenoids with 31-norcycloartanone structure were isolated for the first time from the Solanum genus. Cycloeucalenone and 24-oxo-31-norcycloartanone were the main constituents of the dichloromethane extract of Solanum cernuum Vell. leaves [7% (w/w) and 1.47% (w/w)]. Both triterpenoids were tested against human tumour cell lines, and 24-oxo-31-norcycloartanone was significantly active and selective against the lung tumour cell line NCI-H460 with total growth inhibition at 1.10 microg/mL, growth inhibition 50 at 0.19 microg/mL and lethal concentration 50 at 8.43 microg/mL, while cycloeucalenone showed poor activity. A homologous series of alkanes (C25-C34), beta-sitosterol, and the xanthophyll lutein were also identified. The antiulcer activity was assayed for the dichloromethane extract. In the gastric ulcer model induced by 95% ethanol, administration of 500, 1000 and 2000 mg/kg/po dichloromethane extract gave ulcer lesion indices of, respectively, 38.2, 61.0 and 81.9%, while carbenoxolone inhibited 88.9% at 200 mg/kg. In the gastric ulcer model induced by indomethacin the dichloromethane extract showed a small percentage of lesion inhibition. The ethanol extract was also analyzed and was mainly composed of glycoalkaloids, peptides and disaccharides.
House Dust Mite-Specific Sublingual Immunotherapy Prevents the Development of Allergic Inflammation in a Mouse Model of Experimental Asthma (2016)

The efficacy of Der f-SLIT was demonstrated in prophylactic and therapeutic conditions using experimental mouse models of HDM-induced airway inflammation. A potential role of a so far underestimated lymphocyte subpopulation was also indicated.
PatternMarkers & GWCoGAPS for novel data-driven biomarkers via whole transcriptome NMF (2016)

Abstract Summary Non-negative Matrix Factorization (NMF) algorithms associate gene expression with biological processes (e.g., time-course dynamics or disease subtypes). Compared with univariate associations, the relative weights of NMF solutions can obscure biomarkers. Therefore, we developed a novel PatternMarkers statistic to extract genes for biological validation and enhanced visualization of NMF results. Finding novel and unbiased gene markers with PatternMarkers requires whole-genome data. However, NMF algorithms typically do not converge for the tens of thousands of genes in genome-wide profiling. Therefore, we also developed Genome-Wide CoGAPS Analysis in Parallel Sets (GWCoGAPS), the first robust whole genome Bayesian NMF using the sparse, MCMC algorithm, CoGAPS. This software contains analytic and visualization tools including a Shiny web application, patternMatcher, which are generalized for any NMF. Using these tools, we find granular brain-region and cell-type specific signatures with corresponding biomarkers in GTex data, illustrating GWCoGAPS and patternMarkers ascertainment of data-driven biomarkers from whole-genome data. Availability PatternMarkers &amp; GWCoGAPS are in the CoGAPS Bioconductor package (3.5) under the GPL license. Contact gsteinobrien@jhmi.edu ; ccolantu@jhmi.edu ; ejfertig@jhmi.edu
Synthesis and characterization of Zn2GeO4/Mg-MOF-74 composites with enhanced photocatalytic activity for CO2 reduction (2018)

Zn<sub>2</sub>GeO<sub>4</sub>/Mg-MOF-74 composites are explored for artificial CO<sub>2</sub> phototransformation under mild conditions.
Caravan - A global community dataset for large-sample hydrology (2023)

High-quality datasets are essential to support hydrological science and modeling. Several datasets exist for specific countries or regions (e.g. the various CAMELS datasets). However, these datasets lack standardization, which makes global studies difficult. Additionally, creating large-sample datasets is a time and resource consuming task, often preventing the release of data that would otherwise be open. Caravan (as in &amp;#8220;a series of camels&amp;#8221;) is an initiative that tries to solve both of these problems by creating an open data processing environment in the cloud for the community to use.Caravan is a globally consistent and open datasetCaravan leverages globally available data sources that are published under an open license to derive meteorological forcings and attributes for any catchment. We use ERA5-Land for meteorological forcings and hydrological reference states (SWE and four levels of soil moisture) and HydroATLAS for the catchment attributes. Currently, Caravan consists of 6830 gauges with daily streamflow data (median record length ~30 years), 9 meteorological variables (from 1981 - 2020) in different daily aggregations, 4 hydrological reference states, and a total of 221 catchment attributes.Caravan is derived entirely in the cloudAll meteorological time series (and hydrological reference states) from ERA5-Land are processed on Google Earth Engine, which removes the burden of downloading and processing large amounts of raw gridded data. Similarly, all catchment attributes are computed on Earth Engine. The code used to derive Caravan is publicly available (https://github.com/kratzert/Caravan/) . Once you have streamflow records and the corresponding catchment polygons, deriving all other data (forcing data and attributes) is a matter of a few hours of actual work. Depending on the number of catchments, their size and spatial distribution, that are being processed at once on Earth Engine , it might take a day or two for Earth Engine to extract meteorological data and catchment attributes.&amp;#160;Most importantly: Caravan is a community projectEven though the existing data in Caravan has good coverage over most climate zones, the spatial coverage is still patchy. Here is where we see Caravan as a community effort. Given the provided code, everybody with access to streamflow data and the authorisation to redistribute it can create a Caravan extension with minimal effort and share the extension with the community, thus contributing to a dynamically growing dataset. A full step-by-step tutorial is available at https://github.com/kratzert/Caravan/wiki. We envision that, with many people participating, this will result in a truly global and spatially consistent, large-sample hydrology dataset. A first Caravan extension was already published by Julian Koch (https://zenodo.org/record/7396466), which increased the number of gauges to 7138, by adding 308 gauges in Denmark.
A non-charge-sheet analytic theory for undoped symmetric double-gate MOSFETs from the exact solution of Poisson's equation using SPP approach (2004)

A non-charge-sheet based analytic theory for undoped symmetric double-gate MOSFETs is presented in this paper. The formulation is based on the exact solution of the Poisson's equation to solve for electron concentration directly rather than relying on the surface potential alone. Therefore, carrier distribution in the channel away from the surface is also taken care, giving a non-charge-sheet model compatible with the classical Pao-Sah model. The formulated model has an analytic form that does not need to solve for the transcendent equation as in the conventional surface potentials or Pao-Sah formulation. The validity of the model has also been demonstrated by extensive comparison with AMD double-gate MOSFET's data.
A Study on Hydrodynamic Stiffness Characteristics of Air Bearing for High Speed Spindle (2002)

This study was carried out as one of efforts to overcome difficulties in air bearing design due to low stiffness and low damping. Hydrodynamic effects on hydrodynamic stiffness of a fluid film in a high speed air bearing with two-row air sources are investigated. The hydrodynamic effects by the high speed over DN 1,000,000 and eccentricity of a journal which are not considered in conventional design of an air bearing need to be reconsidered. The hydrodynamic effects, which dominantly influence on the load capacity of air bearing, are caused mainly by journal speed, eccentricity, and the source positions. The two-row source arrangement in the air bearing produces quite unique hydrodynamic effects with respect to pressure distribution of the air film. Optimal arrangement of the two-row sources improves performance of an air bearing in film reaction force and loading capacity of high speed spindles. This study compares the pressure distributions by numerical simulations as a function of eccentricity of journal and the source positions. The air source position 1/7L from one end of an air bearing was found to be superior to source position of 1/4L. The dynamic stiffness were obtained using a two-dimensional cutting method which can directly measure the cutting reaction forces and the displacements of the spindle in two directions using a tool dynamometer and transducer sensors. Heat generation in the air film can not be negligible over the speed of DN 2,000,000. In order to analysis effects of heat generation on the characteristics of air bearing, high cooling bearing spindle and low cooling bearing spindle were tested and compared. Characteristics of the frequency response of shaft and motion of run out errors were different for the spindle. The test results show that, in the case of low cooling bearing spindle, the stiffness became smaller due to heat generation. The results, which were obtained tor high speed region, may be used as a design information for spindle which can be applied to precision devices such as ultra precision grinding and ultra high speed 'milling.
Cross-sell (2000)

We develop a method for recommending products to customers with applications to both on-line and surface mail promotional offers. Our method differs from previous work in collaborative filtering [8] and imputation [18], in that we assume probabilities are conditionally independent. This assumption, which is also made in Naive Bayes [5], enables us to pre-compute probabilities and store them in main memory, enabling very fast performance on millions of customers. The algorithm supports a variety of tunable parameters so that the method can address different promotional objectives. We tested the algorithm at an on-line hardware retailer, with 17,400 customers divided randomly into control and experimental groups. In the experimental group, clickthrough increased by +40% (p<0.01), revenue by +38% (p<0.07), and units sold by +61% (p<0.01). By changing the algorithm’s parameter settings we found that these results could be improved even further. This work demonstrates the considerable potential of automated data mining for dramatically increasing the profitability of on and off-line retail promotions.
Supplementary Data from CDK9 Blockade Exploits Context-dependent Transcriptional Changes to Improve Activity and Limit Toxicity of Mithramycin for Ewing Sarcoma (2023)

&lt;p&gt;Supplementary Table S2 and Supplementary Figures S1 to S10&lt;/p&gt;
Cutting Edge: Human CD49e− NK Cells Are Tissue Resident in the Liver (2017)

Most knowledge on NK cells is based on studies of what are now known as conventional NK cells in the mouse spleen or human peripheral blood. However, recent studies in mice indicate the presence of tissue-resident NK cells in certain organs, such as the liver, that display different markers and transcription factor dependencies as compared with conventional NK cells. In this study, we provide evidence from cytometry by time-of-flight analysis and humanized mice indicating that human CD49e<sup>-</sup> NK cells are tissue resident in the liver. Thus, these studies indicate that tissue-resident NK cells are evolutionarily conserved in humans and mice, providing a foundation to explore their role in human disease.
Bone marrow transplantation as effective treatment of central nervous system disease in globoid cell leukodystrophy, metachromatic leukodystrophy, adrenoleukodystrophy, mannosidosis, fucosidosis, aspartylglucosaminuria, Hurler, Maroteaux-Lamy, and Sly syndromes, and Gaucher disease type III (1999)

Over 400 patients with lysosomal and peroxisomal storage diseases have received hematopoietic stem cell transplantation from normal donors. Without treatment, all of these diseases have an inexorable fate leading to central nervous system deterioration and early death. On the other hand, all of the engrafted hosts have had a remarkable positive clinical improvement in response to normalization of previously deficient enzymatic activity. Survival data for those engrafted indicates continued life-span as long as two decades beyond transplantation. The particular diseases treated in this way are included in this article. The specific indications and methods for transplantation are also included in this article.
Microstructural Analysis of Random Hole Optical Fibers (2004)

A new type of optical fiber, the random hole optical fiber, has been fabricated and consists of a solid silica central core region surrounded by a porous silica cladding region. The holes present in the cladding region are random in both spatial location and in size, varying from approximately 25 nm to 2.5 microns in radius. Over a thousand holes are present in the fiber. The spectral attenuation in the fiber was measured to be about 2.0 dB/m at 1550 nm. The fibers were prepared by the incorporation of a gas producing agent in the optical fiber preform, which generated the holes in situ during the fiber drawing process.
Mechlorethamine cross-links deoxyguanosine residues at 5'-GNC sequences in duplex DNA fragments (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMechlorethamine cross-links deoxyguanosine residues at 5'-GNC sequences in duplex DNA fragmentsJulie T. Millard, Stanley Raucher, and Paul B. HopkinsCite this: J. Am. Chem. Soc. 1990, 112, 6, 2459–2460Publication Date (Print):March 1, 1990Publication History Published online1 May 2002Published inissue 1 March 1990https://pubs.acs.org/doi/10.1021/ja00162a079https://doi.org/10.1021/ja00162a079research-articleACS PublicationsRequest reuse permissionsArticle Views360Altmetric-Citations86LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Observations on the linear programming formulation of the single reflector design problem (2012)

We implemented the linear programming approach proposed by Oliker and by Wang to solve the single reflector problem for a point source and a far-field target. The algorithm was shown to produce solutions that aim the input rays at the intersections between neighboring reflectors. This feature makes it possible to obtain the same reflector with a low number of rays - of the order of the number of targets - as with a high number of rays, greatly reducing the computation complexity of the problem.
Isolation and Molecular Analysis of the Gene Cluster for the Arginine Deiminase System from Streptococcus gordonii DL1 (2002)

The arginine deiminase (AD) system (ADS) is one of two major ammonia-generating pathways in the oral cavity that play important roles in oral biofilm pH homeostasis and oral biofilm ecology. To initiate a study of the Streptococcus gordonii ADS, the ADS gene cluster was isolated from subgenomic DNA libraries of S. gordonii DL1 by using an arcB-specific probe. Nucleotide sequence analysis revealed six open reading frames (ORFs) that were arranged contiguously; the first five ORFs were transcribed in the same direction, as an apparent operon, and the sixth was transcribed in the opposite direction. The ORFs were found to share significant homologies and to correspond closely in molecular mass to previously characterized arc genes; thus, they were designated arcA (AD), arcB (ornithine carbamyltransferase), arcC (carbamate kinase), arcD (arginine-ornithine antiporter), arcT (dipeptidase), and arcR (regulator). A putative sigma(70) promoter (ParcA [TTGTGT-N(19)-TAGAAT]) was mapped 5' to arcA by primer extension, and the expression of ParcA was shown to be inducible by arginine and repressible by glucose, in agreement with AD specific activities measured in the wild-type strain. To investigate the function of ArcR in the differential expression of the arc operon, arcR was insertionally inactivated by a KM resistance marker flanked by T4 transcription/translation termination signals, and the expression of ParcA was monitored by primer extension in the wild-type and ArcR-deficient strains. Lower levels of arcA expression, as well as lower levels of AD activity, were consistently observed in the ArcR-deficient strain compared to wild-type cells, regardless of the growth conditions. Thus, ArcR is a transcriptional activator that is required for induction and optimal expression of the S. gordonii ADS gene cluster.
Receptor Activator of NF-κB Orchestrates Activation of Antiviral Memory CD8 T Cells in the Spleen Marginal Zone (2017)

The spleen plays an important role in protective immunity to bloodborne pathogens. Macrophages and dendritic cells (DCs) in the spleen marginal zone capture microbial antigens to trigger adaptive immune responses. Marginal zone macrophages (MZMs) can also act as a replicative niche for intracellular pathogens, providing a platform for mounting the immune response. Here, we describe a role for RANK in the coordinated function of antigen-presenting cells in the spleen marginal zone and triggering anti-viral immunity. Targeted deletion of RANK results in the selective loss of CD169<sup>+</sup> MZMs, which provide a niche for viral replication, while RANK signaling in DCs promotes the recruitment and activation of anti-viral memory CD8 T cells. These studies reveal a role for the RANKL/RANK signaling axis in the orchestration of protective immune responses in the spleen marginal zone that has important implications for the host response to viral infection and induction of acquired immunity.
Protective effects from Houttuynia cordata aqueous extract against acetaminophen-induced liver injury (2014)

These results support that HCAE could provide hepato-protection.
REVIEW ARTICLE: Mid‐urethral synthetic slings for female stress urinary incontinence (2010)

• Mid-urethral synthetic slings (MUSS) have grown in acceptance and popularity to gain a foremost position in stress urinary incontinence (SUI) surgery. • There are numerous studies that provide a large amount of Level 1 and 2 evidence that support the concept of a sling placed at the level of the mid-urethra. • Long-term follow-up has been published for the original tension-free vaginal tape (TVT) procedure with the most recent publication providing Level 2 evidence with mean follow-up of 11.5 years of 69/91 (77%) of patients from the original series. There was objective cure was in 90% of women and 77% considered themselves subjectively cured, based on the Patient Global Impression of Improvement. • Level 1 evidence with long-term follow-up has been provided comparing colposuspension to TVT at 2 and 5 years. At 5 years for the primary efficacy variable of a negative 1 h stress pad test, there was no difference in success (81% vs 90%). • Two recent meta-analyses provide Level 1 evidence comparing outcomes for retropubic vs transobturator MUSS. One included 18 studies, randomized and cohort: cohort studies had a 12.3% failure rate for transobturator and 13.7% failure for the retropubic approach, randomized studies showed 5.7% failure in the transobturator vs 7.8% in the retropubic group. The other meta-analysis included 11 studies published 2008-2009, which found that the short-term cure rate was borderline inferior for the transobturator tape group (odds ratio 0.62; 95% confidence interval 0.37-1.00), nearly reaching statistical significance (P= 0.05). • This review details further comparator evidence and evidence for use in specific patient groups (elderly, obese, intrinsic sphincter deficiency, mixed UI).