gebhart/patrepeval huggingface dataset:
Histamine Content of Canadian Wines Determined by Reverse Phase High Performance Liquid Chromatography (1979)

Histamine in Canadian wines was determined by U.V. absorption of an ortho-phthaldialdehyde derivative using high performance liquid chromatography. Canadian wines average 1.84 and range between 0.09 and 6.11 mg histamine per liter of wine. For similar vinifications there was no significant difference between American hybrids, French-American hybrids and vinifera wines. Differences were noted, after amelioration, bentonite fining, and hot pressing.
Interactive Multimodal System Characterization in the Internet of Things Context (2022)

Conférence Virtuelle en ligne, la ville et le pays seront à changer mais on est obligé d'en mettre dans le formulaire de saisie
Effect of Grain Boundary Character Distribution on Stress Corrosion Cracking Behavior in Austenitic Stainless Steels (2005)

The effect of grain boundary character distribution (GBCD) on intergranular stress corrosion cracking (IGSCC) in austenitic stainless steels in high temperature water was verified experimentally. GBCD control using the strain annealing method increased the fraction of low- S coincidence site lattice (CSL) boundaries and the segmentalized network of random grain boundaries in austenitic stainless steels. The fractions of low- S CSL boundaries of GBCD controlled steels were 75–85%, while those of uncontrolled steels were 60–70%. Creviced bent beam tests were conducted at 561 K in pure water containing 8 ppm dissolved oxygen for stress corrosion cracking (SCC) evaluation. The tests revealed that GBCD control suppressed IGSCC initiation or propagation and that cracks were predominantly propagated along random grain boundaries. It is considered that induced lower- S CSL boundaries result in high resistance to IGSCC.
Hypothermic Liquid Ventilation Prevents Early Hemodynamic Dysfunction and Cardiovascular Mortality After Coronary Artery Occlusion Complicated by Cardiac Arrest in Rabbits (2013)

Achieving hypothermia rapidly is critical to improve the cardiovascular outcome after cardiac arrest with underlying myocardial infarction.
A Data integration technique for pore pressure evaluation and drilling prognosis (1996)

In [1] we describe the development a method for inversion of seismic and well-log data with respect to underground fluid pressure by combining basin modelling and geophysical inversion techniques. In this paper we present a further refined version of the method by introducing new tools for integrating multiple data sources in a 3-D grid of an area where a pressure prognosis is made.
Chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation (2020)

High-altitude adaptation of Tibetans represents a remarkable case of natural selection during recent human evolution. Previous genome-wide scans found many non-coding variants under selection, suggesting a pressing need to understand the functional role of non-coding regulatory elements (REs). Here, we generate time courses of paired ATAC-seq and RNA-seq data on cultured HUVECs under hypoxic and normoxic conditions. We further develop a variant interpretation methodology (vPECA) to identify active selected REs (ASREs) and associated regulatory network. We discover three causal SNPs of EPAS1, the key adaptive gene for Tibetans. These SNPs decrease the accessibility of ASREs with weakened binding strength of relevant TFs, and cooperatively down-regulate EPAS1 expression. We further construct the downstream network of EPAS1, elucidating its roles in hypoxic response and angiogenesis. Collectively, we provide a systematic approach to interpret phenotype-associated noncoding variants in proper cell types and relevant dynamic conditions, to model their impact on gene regulation.
Mechanisms underlying the monocyte-mediated antibody-dependent killing of Plasmodium falciparum asexual blood stages. (1995)

The relevance of the antibody-dependent cellular inhibition (ADCI) of Plasmodium falciparum to clinical protection has been previously established by in vitro studies of material obtained during passive transfer of protection by immunoglobulin G in humans. We here report further in vitro investigations aimed at elucidating the mechanisms underlying this ADCI effect. Results obtained so far suggest that (a) merozoite uptake by monocytes (MN) as well as by polymorphonuclear cells has little influence on the course of parasitemia; (b) the ADCI effect is mediated by a soluble factor released by MN; (c) this or these factors are able to block the division of surrounding intraerythrocytic parasites at the one nucleus stage; (d) the critical triggering antigen(s) targeted by effective Abs would appear to be associated with the surface of merozoites, as opposed to that of infected red blood cells; (e) the MN receptor for Abs effective in ADCI is apparently Fc gamma RII, and not RI; (f) MN function is up- and down-regulated by interferon-gamma and interleukin 4, respectively; and (g) of several potential mediators released by MN, only tumor necrosis factor (TNF) proved of relevance. The involvement of TNF in defense may explain the recently described increased frequency of the TNF-2 high-expression promoter in individuals living in endemic regions despite its compromising role in severe malaria.
A Distributed Location Estimating Algorithm for Wireless Sensor Networks (2006)

The location estimation is a fundamental and essential issue for wireless sensor networks( WSNs). In this paper, we assume that only a few sensor nodes (named as beacon nodes) get their locations by Global Positioning System (GPS) and the remaining nodes without GPS (named as normal nodes) need to estimate their own locations by gathering the nearby neighboring information. Existing works are either too costly or not accurate enough. To improve previous works, we propose a distributed location estimation algorithm for WSNs. In our algorithm, each node without location information only needs to collect the location information of neighboring nodes and use simple computation to estimate its location. Besides, we improve the accuracy of the normal node's estimative region by discarding the communication area of the beacon node (named as the farther neighboring beacon node), which does not cover the normal node, from the original estimative region. We derive some rules to adjust the estimative region according to the relative location of the normal node and the farther neighboring beacon node. Simulation results show that the proposed algorithm achieves better accuracy of estimative locations.
메를로-퐁티의 “신체도식(body schema)”관점에서 본 품새선수의 신체관 (2012)

본 연구는 수련을 통해 형성된 내면의 상태를 외향적으로 표현해야 하는 품새선수들의 신체관에 대하여 메를로-퐁티의 신체도식 관점으로 살펴보고 품새수련의 의미를 설명할 수 있는 단초를 알아보고자 하였다. 4년제 대학 품새선수 12명을 대상으로 심층면담과 참여관찰일지, 선수들의 시합후기 등을 수집하였고 해체-검사-비교-개념화하는 과정으로 분석되었다. 전-객관적인 차원의 “고유한 신체(owned body)”를 규명한 메를로-퐁티의 신체도식 관점에서 살펴본 결과 품새선수들이 습득한 품새에 대한 지식은 정형적인 동작을 반복 훈련함으로서 얻어지는 실천적인 지식이었다. 습관화된 실천적인 지식은 선수들에게 품새동작에 대한 고유감각(proprioception)을 형성하게 함으로서 움직임의 미세한 차이도 감지할 수 있는 능력을 보유하게 하였다. “고유한 신체(owned body)”는 이러한 고유감각(proprioception)과 의식의 지향성에서 비롯되는 지향호(arc intentionnel)를 토대로 신체와 정신이 분리되지 않은 전-객관적인 차원에 위치해 있는 제2의 신체개념을 성립시킨다. 즉 “고유한 신체(owned body)”는 품새선수들의 신체관이 자신을 세계-속에-투사함으로서 신체를 통해 세계를 이해하고 있음을 설명해 주었다.
Anisotropic PrCo$_{5}$ Nanoparticles by Surfactant-Assisted Ball Milling (2009)

Magnetically hard PrCo <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sub> nanoparticles have been produced by using surfactant-assisted high-energy ball milling techniques. The use of surfactant leads to the dispersion of the crashed particles and prevents them from rewelding during the milling process. Heptane was used as the milling medium, and oleic acid as the surfactant. High-energy ball milling experiments took place in a milling vial with steel balls by using a Spex 8000 M high-energy ball milling machine. The coercivity was found to increase with milling time with a value of 6.8 kOe after 12 h of milling. TEM data showed that the milled powders consist of nanoparticles with an average size of 8-10 nm.
Delay Robustness of an $\mathcal {L}_1$ Adaptive Controller for a Class of Systems With Unknown Matched Nonlinearities (2017)

This paper studies the delay robustness of an L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> adaptive controller designed for systems with unknown matched nonlinearities and unknown input-gain matrices. The analysis establishes rigorously the existence of a positive lower bound for the closed-loop system's time-delay margin (TDM), provided that a filter bandwidth and an adaptive gain are chosen sufficiently large. In this case, if the input delay is below a critical value, then the state and control input of the control system follow those of a nonadaptive, robust reference system closely. The analysis also suggests a way to estimate this lower bound for the delay robustness using Padé approximants. Results from forward simulation are consistent with the Padé estimate and with an explicit upper bound on the TDM which decays to 0 as the filter bandwidth grows without bound.
Determination of sodium sulfate content in laundry powder by low-pressure ion chromatography with UV detection (2006)

The determination of sodium sulfate content in laundry powder by low-pressure ion chromatography in cooperated with UV detection was studied.The optimum analytical conditions were identified.The exchange capacity of the anion separation column(Φ5×50 mm)is 0.04 mmol/g,the eluent was potassium hydrogen phthalate solution with concentration of(0.2 mmol/L,)pH of 4.95 and flow rate of 0.55 mL/min.The volume of the sample injection is 25 μL and the UV detection wavelength is 280 nm.Under these conditions,the plot SO~(2-)_4 displays good linearity in the range of 50 mg/L～500 mg/L with correlation coefficient of 0.998 8 and relative standard deviation of 4.62%.This method was applied to the determination of sodium sulfate content in the laundry powder and the result was compared with that of GB/T 15817-1995.Good results were obtained.
Growth kinetics and integrin expression of fibroblasts infiltrating devitalised patellar tendons are different from those of intrinsic fibroblasts (2005)

We compared the biological characteristics of extrinsic fibroblasts infiltrating the patellar tendon with those of normal, intrinsic fibroblasts in the normal tendon in vitro. Infiltrative fibroblasts were isolated from the patellar tendons of rabbits six weeks after an in situ freeze-thaw treatment which killed the intrinsic fibroblasts. These intrinsic cells were also isolated from the patellar tendons of rabbits which had not been so treated. Proliferation and invasive migration into the patellar tendon was significantly slower for infiltrative fibroblasts than for normal tendon fibroblasts. Flow-cytometric analysis indicated that expression of alpha5beta1 integrin at the cell surface was significantly lower in infiltrative fibroblasts than in normal tendon fibroblasts. The findings suggest that cellular proliferation and invasive migration of fibroblasts into the patellar tendon after necrosis are inferior to those of the normal fibroblasts. The inferior intrinsic properties of infiltrative fibroblasts may contribute to a slow remodelling process in the grafted tendon after ligament reconstruction.
Platelet Receptor Occupancy with Factor IXa Promotes Factor X Activation (1989)

To investigate the activated platelet surface as a locus for factor X activation, the functional consequences of factor IXa binding to platelets were studied. The concentration of factor IXa required for half-maximal rates of factor X activation in the presence of factor VIIIa and thrombin-activated platelets was 0.53 nM, which is close to the Kd (0.56 nM) for factor IXa binding to platelets under identical conditions, determined from equilibrium binding studies. In direct comparative experiments, there was a close correspondence between equilibrium binding of factor IXa to thrombin-activated platelets in the presence of factor VIIIa and kinetic determinations of factor X activation rates. Analysis by polyacrylamide gel electrophoresis revealed that 125I-labeled factor IXa bound to platelets was structurally intact and did not form covalent complexes with platelet proteins. Factor IXa active site-inhibited by 5-dimethylaminonaphthalene-1-sulfonyl glutamyl-glycylarginyl chloromethyl ketone was shown to be a competitive inhibitor of factor IXa binding in the absence (Ki = 2.3 nM) and presence (Ki = 0.43 nM) of factor VIIIa and factor X and of factor X activation (Ki = 0.4 nM) by factor IXa in the presence of factor VIIIa, indicating that the generation of factor Xa is not required for factor IXa binding and that factor IXa bound to activated platelets in the presence of factor VIIIa is closely coupled with rates of factor X activation. We conclude that factor IXa bound tightly to a platelet receptor in the presence of factor VIIIa is the enzyme active in factor X activation.
Skeletal Ryanodine Receptors Are Involved in Impaired Myogenic Differentiation in Duchenne Muscular Dystrophy Patients (2021)

Duchenne muscular dystrophy (DMD) is characterized by progressive muscle wasting following repeated muscle damage and inadequate regeneration. Impaired myogenesis and differentiation play a major role in DMD as well as intracellular calcium (Ca<sup>2+</sup>) mishandling. Ca<sup>2+</sup> release from the sarcoplasmic reticulum is mostly mediated by the type 1 ryanodine receptor (RYR1) that is required for skeletal muscle differentiation in animals. The study objective was to determine whether altered RYR1-mediated Ca<sup>2+</sup> release contributes to myogenic differentiation impairment in DMD patients. The comparison of primary cultured myoblasts from six boys with DMD and five healthy controls highlighted delayed myoblast differentiation in DMD. Silencing <i>RYR1</i> expression using specific si-RNA in a healthy control induced a similar delayed differentiation. In DMD myotubes, resting intracellular Ca<sup>2+</sup> concentration was increased, but RYR1-mediated Ca<sup>2+</sup> release was not changed compared with control myotubes. Incubation with the RYR-calstabin interaction stabilizer S107 decreased resting Ca<sup>2+</sup> concentration in DMD myotubes to control values and improved calstabin1 binding to the RYR1 complex. S107 also improved myogenic differentiation in DMD. Furthermore, intracellular Ca<sup>2+</sup> concentration was correlated with endomysial fibrosis, which is the only myopathologic parameter associated with poor motor outcome in patients with DMD. This suggested a potential relationship between RYR1 dysfunction and motor impairment. Our study highlights RYR1-mediated Ca<sup>2+</sup> leakage in human DMD myotubes and its key role in myogenic differentiation impairment. RYR1 stabilization may be an interesting adjunctive therapeutic strategy in DMD.
Compensation of intermodulation distortion of laser diode by using optoelectronically predistorted signals (2006)

Abstract We have experimentally demonstrated the predistortion scheme for linearization of a laser diode which transmits 1.2‐ and 1.25‐GHz RF signal over single‐mode fiber. The suppression of intermodulation distortion was achieved by using an additional laser diode to realize the predistorted signals. We have shown a 22.5‐dB reduction of the 3 rd ‐order intermodulation distortion and an 11‐dB improvement in the spurious‐free dynamic range. © 2006 Wiley Periodicals, Inc. Microwave Opt Technol Lett 48: 1144–1148, 2006; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.21566
Single-Chip Heterogeneous Computing: Does the Future Include Custom Logic, FPGAs, and GPGPUs? (2010)

To extend the exponential performance scaling of future chip multiprocessors, improving energy efficiency has become a first-class priority. Single-chip heterogeneous computing has the potential to achieve greater energy efficiency by combining traditional processors with unconventional cores (U-cores) such as custom logic, FPGAs, or GPGPUs. Although U-cores are effective at increasing performance, their benefits can also diminish given the scarcity of projected bandwidth in the future. To understand the relative merits between different approaches in the face of technology constraints, this work builds on prior modeling of heterogeneous multicores to support U-cores. Unlike prior models that trade performance, power, and area using well-known relationships between simple and complex processors, our model must consider the less-obvious relationships between conventional processors and a diverse set of U-cores. Further, our model supports speculation of future designs from scaling trends predicted by the ITRS road map. The predictive power of our model depends upon U-core-specific parameters derived by measuring performance and power of tuned applications on today's state-of-the-art multicores, GPUs, FPGAs, and ASICs. Our results reinforce some current-day understandings of the potential and limitations of U-cores and also provides new insights on their relative merits.
Application of fluorescence polarization microscopy to measure fluorophore orientation in the outer hair cell plasma membrane (2007)

The biophysical properties and organization of cell membranes regulate many membrane-based processes, including electromotility in outer hair cells (OHCs) of the cochlea. Studies of the membrane environment can be carried out by measuring the orientation of membrane-bound fluorophores using fluorescence polarization microscopy (FPM). Due to the cylindrical shape of OHCs, existing FPM theory developed for spherical cells is not applicable. We develop a new method for analyzing FPM data suitable for the quasi-cylindrical OHC. We present the theory for this model, as well as a study of the orientation of the fluorescent probe pyridinium, 4-[2-[6-(dioctylamino)-2-naphthalenyl]ethenyl]-1-(3-sulfopropyl) (di-8-ANEPPS) in the OHC membrane. Our results indicate that the absorption transition dipole moment of di-8-ANEPPS orients symmetrically about the membrane normal at 27 deg with respect to the plane of the membrane. The observed agreement between theoretical predictions and experimental measurements establishes the applicability of FPM to study OHC plasma membrane properties.
The Etiology of Hypothyroidism Is Revealed by Alternative Genetics Association Study Methodologies (2022)

Abstract Hypothyroidism is a common disorder of the endocrine system in which the thyroid gland does not produce enough thyroid hormones. About 12% of the population in the USA will develop substantial thyroid deficiency over their lifetime, mostly as a result of iodine deficiency. The hypothyroidism phenotype also includes individuals that suffer from thyroid development abnormalities (congenital hypothyroidism, CH). Using a large population study, we aimed to identify the functional genes associated with an increase or decreased risk for hypothyroidism (ICD-10, E03). To this end, we used the gene-based proteome-wide association study (PWAS) method to detect associations mediated by the effects of variants on the protein function of all coding genes. The UK-Biobank (UKB) reports on 13,687 cases out of 274,824 participants of European ancestry, with a prevalence of 7.5% and 2.0% for females and males, respectively. The results from PWAS for ICD-10 E03 are a ranked list of 77 statistically significant genes (FDR-q-value &lt;0.05) and an extended list of 95 genes with a weaker threshold (FDR-q-value &lt;0.1). Validation was performed using the FinnGen Freeze 7 (Fz7) database across several GWAS with 33.5k to 44.5k cases. We validated 9 highly significant genes across the two independent cohorts. About 12% of the PWAS reported genes are strictly associated with a recessive inheritance model that is mostly overlooked by GWAS. Furthermore, PWAS performed by sex stratification identified 9 genes in males and 63 genes in females. However, resampling and statistical permutation tests confirmed that the genes involved in hypothyroidism are common to both sexes. Many of these genes function in the recognition and response of immune cells, with a strong signature of autoimmunity. Additional genetic association protocols, including PWAS, TWAS (transcriptional WAS), Open Targets (OT, unified GWAS) and coding-GWAS, revealed the complex etiology of hypothyroidism. Each association method highlights a different facet of the disease, including the developmental program of CH, autoimmunity, gene dysregulation, and sex-related gene enrichment. We conclude that genome association methods are complementary while each one reveals different aspects of hypothyroidism. Applying a multiple-protocol approach to complex diseases is expected to improve interpretability and clinical utility.
EFFECTS OF DIFFUSER LENGTH ON THE PERFORMANCE OF EJECTORS WITHOUT INDUCED FLOW (1961)

Abstract : An investigation of ejectors without induced flow was made to determine the effects of varying diffuser lengths on ejector performance. Four 18-deg half angle conical nozzles having constant exit diameters and different throat diameters and two contoured nozzles having zero-deg half angles at the exit were used as the ejector driving nozzles. Unheated air was used for all tests. The diffuser length-to-diameter ratios were varied between 0.7 and 21.5, and three cylindrical ducts of different diameters were used both with and without a subsonic diffuser. An empirical method was developed to estimate the starting and operating pressure ratios of such ejector configurations using simple-determined one-dimensional normal shock relationships.
Prophylactic Use of Antibiotics for Procedures after Total Joint Replacement (1997)

In an era of increasing managed care, during which costs are being scrutinized and management algorithms are being initiated at many levels of care, the use of strategies to prevent the development of active disease seems attractive. Treatment with antibiotics to prevent infection is one area where the potential benefits of disease prevention appear to far outweigh the costs. In fact, because they are relatively inexpensive and they can be administered easily, antibiotics are frequently administered prophylactically before procedures that might lead to bacteremia.

The prophylactic use of antibiotics when an invasive procedure is performed in patients who have a prosthetic joint has been the subject of intense debate10,21,25,54,66,84,85,103,107,144,156,162. It has been estimated that as many as 500,000 total joint replacements are performed each year in the United States49, and this number is expected to grow as the population ages. Most of these replacements involve the lower extremities, with an estimated 125,000 total hip replacements, 84,000 hip hemiarthroplasties, and 179,000 total knee replacements being performed each year49. Approximately 5000 total shoulder replacements also are performed each year49. The effect of the implant on the patient's resistance to infection is important. Total joint implants have been shown to be surrounded by an immuno-incompetent, fibro-inflammatory zone that may impair the body's ability to eliminate bacteria around the implant51. This zone may become more stable with time, but a foreign object always represents a possible site for infection. The sites of prosthetic joints are placed at potential risk for infection by procedures that cause transient bacteremia. Because the average per capita incidence of dental visits in the United States is 2.1 …