gebhart/patrepeval huggingface dataset:
Caffeoylquinic Acids in Centella asiatica Reverse Cognitive Deficits in Male 5XFAD Alzheimer’s Disease Model Mice (2020)

<i>Centella asiatica</i> (CA) is an edible plant and a popular botanical dietary supplement. It is reputed, in Ayurveda, to mitigate age-related cognitive decline. There is a considerable body of preclinical literature supporting CA's ability to improve learning and memory. This study evaluated the contribution of CA's triterpenes (TT), widely considered its active compounds, and caffeoylquinic acids (CQA) to the cognitive effects of CA water extract (CAW) in 5XFAD mice, a model of Alzheimer's disease. 5XFAD mice were fed a control diet alone, or one containing 1% CAW or compound groups (TT, CQA, or TT + CQA) equivalent to their content in 1% CAW. Wild-type (WT) littermates received the control diet. Conditioned fear response (CFR) was evaluated after 4.5 weeks. Female 5XFAD controls showed no deficit in CFR compared to WT females, nor any effects from treatment. In males, CFR of 5XFAD controls was attenuated compared to WT littermates (<i>p</i> = 0.005). 5XFAD males receiving CQA or TT + CQA had significantly improved CFR (<i>p</i> < 0.05) compared to 5XFAD male controls. CFR did not differ between 5XFAD males receiving treatment diets and WT males. These data confirm a role for CQA in CAW's cognitive effects.
Underwater observatory lander for the seafloor ecosystem monitoring using a video system (2016)

We were involved in development of a small lander for low-price and usability. The free fall type hadal zone research lander called “Edokko No.1” consists of 3 glass spheres and wireless connectable rubber bridge, and an observation equipment and levitation transponder device can be installed in the glass sphere. A continuous monitoring operation of periodic variations of surrounding ecosystem at deep-seabed is essential for acquiring baseline data and knowledge towards proposal of an appropriate methodology for underwater environmental impact assessment. In the demonstration test in 2013, the video of the hadal zone at the depth of 7800m has been acquired. By the bate trap survey, to observe the amphipods and a hadal fish (Pseudoliparis amblystomopsis). We will demonstrate the transition of deep-sea ecosystem. Time-lapse observation of the seabed is useful to an understanding of the seabed environment.
A fully differential switched-current delta-sigma modulator using a single 3.3-V power-supply voltage (2002)

This paper presents the design of a fully differential second-order delta-sigma modulator using a single 3.3-V power supply voltage. At the system level, we tailor the modulator structure considering the similarity and difference of switched-capacitor and switched-current realizations. At the circuit level, we propose a new switched-current memory cell and integrator with improved common mode feedback, without which low power-supply-voltage operation would not be possible. Other building blocks such as 1-bit A/D and D/A converters are presented as well. The whole modulator has been implemented in AMS' 0.8-/spl mu/m double-metal digital CMOS process. It occupies an active area of 0.53/spl times/0.48 mm/sup 2/ and consumes a current of 0.6 mA.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Induced Expression ofVEGFC,ANGPT, andEFNB2and Their Receptors Characterizes Neovascularization in Proliferative Diabetic Retinopathy (2019)

This study described a PDR neovascularization model in which pathological retina-secreted vascular endothelial growth factor A (VEGFA) enhanced the expression of a set of angiogenesis transcription factors and growth factors, to cooperatively induce the retinal neovascularization. Based on these results, novel potential therapeutic targets and biomarkers for PDR treatment and diagnosis are suggested.
Can Sensitivity and Specificity Be Quantified in the Face of Selection Bias and Small Sample Size? MIBI So-MIBI Not (1990)

A recent study compared conventional planar thallium-201 -myocardial perfusion scintigraphy with single-photon emission computerized tomography and technetium-99m-methoxy isobutyl isonitrile for the diagnosis of coronary artery disease, and concluded that the newer refinements correlate well with the conventional technique. A critical review of the published data, however, shows that selection bias and small sample size seriously compromise the credibility of this study. These limitations might be mitigated if the investigators performing such technology assessment studies made wider use of more sophisticated methods of data analysis based on confidence intervals and receiver-operating characteristic curves.
Infrared laser bone ablation (1988)

The bone ablation characteristics of five infrared lasers, including three pulsed lasers (Nd:YAG, lambda = 1,064 micron; Hol:YSGG, lambda = 2.10 micron; and Erb:YAG, lambda = 2.94 micron) and two continuous-wave lasers (Nd:YAG, lambda = 1.064 micron; and CO2, lambda = 10.6 micron), were studied. All laser ablations were performed in vitro, using moist, freshly dissected calvarium of guinea pig skulls. Quantitative etch rates of the three pulsed lasers were calculated. Light microscopy of histologic sections of ablated bone revealed a zone of tissue damage of 10 to 15 micron adjacent to the lesion edge in the case of the pulsed Nd:YAG and the Erb:YAG lasers, from 20 to 90 micron zone of tissue damage for bone ablated by the Hol:YSGG laser, and 60 to 135 micron zone of tissue damage in the case of the two continuous-wave lasers. Possible mechanisms of bone ablation and tissue damage are discussed.
Mastering COM and COM (1999)

From the Publisher:
COM (Component Object Model) is Microsoft's specification for building distributed applications that work across networks and the Internet. It is a highly complex and mysterious topic, which ties in to everything Microsoft is doing with Windows. In this book aimed at experienced programmers, Ash Rofail unlocks the secrets of programming COM, writing in the classic Mastering style. This is no theoretical treatise but a practical exploration of how to do real things with COM, including creating COM objects, working with the Registry, reusing components, and getting the most out of ActiveX controls. Includes coverage of DCOM and COM+, Microsoft's latest version of the standard for Windows 2000.
Reconstruction with Total Scapular Reverse Total Shoulder Endoprosthesis after Radical Tumor Excision (2021)

Malignant musculoskeletal tumors about the shoulder girdle region involving the scapula are fairly rare, but when diagnosed, challenging and complex surgical treatment may be warranted with the primary goal of improving patient survival. These tumors are typically extensive and infiltrative at the time of presentation, requiring radical resection to achieve margins and obtain local tumor control. Historically, forequarter amputation or flail extremity were the mainstays of treatment in these cases. Presently, with recent advances in diagnostics, imaging, adjuvant therapies, and surgical treatment, many patients presenting with malignant tumors involving the scapula are candidates for limb salvage surgery. Reconstruction with endoprosthesis seems to have gained acceptance as the preferred surgical treatment for such lesions, as this intervention has resulted in improved postoperative function and cosmesis, with an acceptable complication rate. We present our experience with recent advancement in these surgical efforts in the form of shoulder girdle reconstruction with total scapular reverse total shoulder prosthesis after radical tumor excision.
An IEEE 802.11 protocol test-bed in industrial environments using personal computing devices (2006)

IEEE 802.11 is being currently considered to develop telecommunications infrastructures in industrial environments. However, in such environments there may exist a high level of electromagnetic fields (EMF) contamination, due to the machinery in use. Wireless LANs are sensitive to this type of hazard, and therefore the performance of the protocols may be affected inside the industrial facilities. In this paper we conduct a study of the wireless link performance in these industrial scenarios, using personal computing devices. Such equipments will be likely used by employees rather than conventional computers. Since the results do not characterize the environment itself, but the set of environment and hardware, a proper measurement test-bed must include direct measurements with these devices. Besides, due to limitations in these equipments, a specific protocol to measure pairs of packet error probability and latency is also developed. Results reveal a significant linear dependency between both magnitudes, and a large correlation coefficient in the measurements under high EMF activity at mid-large ranges (distances greater than 5 meters)
Hemodynamic responses to magnetic stimulation of carotid sinus in normotensive rabbits (2017)

Objectives: Carotid baroreflex plays a crucial role in regulating arterial pressure. Based on this knowledge, electrical stimulation of carotid sinus was designed for treating resistant hypertension. However, the clinical implication of electrical stimulation of carotid sinus is largely restrained due to obvious invasiveness. This study aimed to evaluate the efficacy of magnetic stimulation of carotid sinus (MSCS), a noninvasive strategy, for lowering blood pressure in rabbits. Methods: MSCS with graded intensities and frequencies were systematically attempted in normotensive rabbits. Blood pressure was recorded dynamically. Sinoaortic denervation and plasma hormone level analyses were performed. Results: When the right carotid sinus was stimulated at 1 Hz frequency, a dose–effect relationship was observed between stimulation intensity (100–250% motor threshold) and mean arterial pressure (MAP) decrement (3.6 ± 1.0 to 10.4 ± 2.3 mmHg). When stimulation intensity was fixed at 200% motor threshold, the median reduction of MAP in 1-Hz group [10.8 (8.6–14.9) mmHg] was significantly higher than that in other frequency groups (all P < 0.05). Heart rates declined transiently after the initiation of MSCS. Compared with baseline (33.9 ± 5.5 pg/ml), plasma epinephrine level increased during MSCS (88.1 ± 9.6, P = 0.002). After ipsilateral sinoaortic denervation, MAP decrement (7.0 ± 0.8 mmHg) was remarkably blunted compared with that in sham animals (13.0 ± 1.1 mmHg, P = 0.001). Conclusion: The current study demonstrated that MSCS treatment can lower the arterial pressure in normotensive rabbits. This preliminarily result warrants further studies to establish the efficacy of MSCS in treating refractory hypertension.
Reactive ion etch of patterned and blanket silver thin films in Cl2/O2 and O2 glow discharges (1999)

Silver (Ag) is being investigated as a potential metal for interconnect technology because it has the lowest bulk resistivity of any metal and higher electromigration resistance than aluminum. Silver dry etch is an important process step in the implementation of this metal as an interconnect. This article demonstrates both blanket and patterned etch of Ag films in a reactive ion-etch reactor using Cl2/O2 and O2 glow discharges. X-ray diffraction and scanning electron microscopy were used to analyze the postetch materials. Stress caused by volume expansion upon the formation of Ag2O, AgO, AgCl, and AgClOx, and possibly the sputtering and formation of volatile products, are also believed to induce the etch. The etch mechanism initiated by stress led to roughness and residues on the postetch surface for a blanket etch, and jagged edges for a line etch. It is not suitable to use the above chemistries for a blanket films etch; but for pattern etch, it showed suitable line formation after resist removal and clean. Further study will be needed to improve roughness, uniformity, and edges geometry of the line edges. Corrosion of Ag in chlorine ambient is an essential issue to be considered in future work.
Cooperating unmanned vehicles (2005)

Effective employment of autonomous multi-vehicle control can meet a critical need in today's military. Swarming unmanned ground and aerial vehicles can achieve militarily effective cooperative action autonomously, using reactive, effects-based behaviors and broadcast-only, decentralized communications. We achieve this control through stigmergic potential fields, a form of cooperative motor schema behavior based upon mathematical functions that are associated with entities in the operational environment of the vehicle. We have demonstrated empirically, as well as through hardware-in-the-loop testing, how reactive swarming behaviors using stigmergic potential fields can offer robustly sufficient behavior with improved total system survivability and total operational effectiveness, particularly under dynamic environmental and operational conditions.
BSUV-Net 2.0: Spatio-Temporal Data Augmentations for Video-Agnostic Supervised Background Subtraction (2021)

Background subtraction (BGS) is a fundamental video processing task which is a key component of many applications. Deep learning-based supervised algorithms achieve very good performance in BGS, however, most of these algorithms are optimized for either a specific video or a group of videos, and their performance decreases dramatically when applied to unseen videos. Recently, several papers addressed this problem and proposed video-agnostic supervised BGS algorithms. However, nearly all of the data augmentations used in these algorithms are limited to the spatial domain and do not account for temporal variations that naturally occur in video data. In this work, we introduce spatio-temporal data augmentations and apply them to one of the leading video-agnostic BGS algorithms, BSUV-Net. We also introduce a new cross-validation training and evaluation strategy for the CDNet-2014 dataset that makes it possible to fairly and easily compare the performance of various video-agnostic supervised BGS algorithms. Our new model trained using the proposed data augmentations, named BSUV-Net 2.0, significantly outperforms state-of-the-art algorithms evaluated on unseen videos of CDNet-2014. We also evaluate the cross-dataset generalization capacity of BSUV-Net 2.0 by training it solely on CDNet-2014 videos and evaluating its performance on LASIESTA dataset. Overall, BSUV-Net 2.0 provides a ~5% improvement in the F-score over state-of-the-art methods on unseen videos of CDNet-2014 and LASIESTA datasets. Furthermore, we develop a real-time variant of our model, that we call Fast BSUV-Net 2.0, whose performance is close to the state of the art.
Cimetidine increases the plasma concentration of hydroxyzine. (1986)

The combination of hydroxyzine and cimetidine is reported to be more effective than hydroxyzine alone in chronic urticaria. The plasma concentration of hydroxyzine was studied in seven patients treated both with the hydroxyzine 25 mg t.i.d. and the combinations of hydroxyzine 25 mg and cimetidine 200 mg t.i.d. Hydroxyzine plasma concentrations were definitely higher during the combination treatment than during hydroxyzine alone. This may explain the effectiveness of the combination treatment.
In situ compatibility studies of lanthanum nickelate with a ceria-based electrolyte for SOFC composite cathodes (2012)

The phase stability and compatibility of intermediate temperature solid oxide fuel cell (IT-SOFC) composite cathodes of lanthanum nickelate, La2NiO4+δ (LNO), and ceria-gadolinium oxide, Ce0.9Gd0.1O2−δ (CGO10), have been investigated by high resolution synchrotron X-ray diffraction (XRD). No reaction was observed between LNO and CGO10 at temperatures of up to 900 °C when the composite is open to an ambient air environment. However, in a sealed capillary environment the 50 : 50 wt% LNO:CGO10 composite undergoes a partially reversible reaction at temperatures of 750 °C and above, whereby LNO decomposes to La2O3 and Ni. Changes in the CGO10 Bragg peaks indicate that this component is actively involved in this process. This study shows that the phase stability of LNO:CGO10 composites is highly dependent on oxygen partial pressure. In addition, it is observed that ex-situXRD is insufficient to determine the presence of reactivity in composite cathodes and that high resolution in situXRD measurements are required to obtain details of the complexity of phase stability in SOFC composite cathodes.
Stereotaxic fine needle aspiration cytology of clinically occult malignant and premalignant breast lesions. (1988)

Stereotaxic fine needle aspiration (FNA) cytology was used to study clinically occult (nonpalpable) breast lesions in 114 consecutive patients with mammographically suspicious findings prior to excisional biopsy. The aspirate contained insufficient material for cytologic evaluation in 15 cases (13.2%), which were histologically diagnosed as benign (7 cases), atypical hyperplasia (7 cases) or carcinoma in situ (1 case). The cytologic findings indicated a benign lesion in 77 cases (67.5%), which were histologically diagnosed as benign (71 cases) or atypical ductal hyperplasia (6 cases). The cytologic sample showed atypia in eight cases (7.0%), which were histologically diagnosed as severe atypical ductal hyperplasia (three cases), carcinoma in situ (one case) or proliferative fibrocystic disease (four cases). In the eight cases (7.0%) cytologically interpreted as probably malignant, histology confirmed six invasive carcinomas, one carcinoma in situ and one fibrocystic disease. Of six cases (4.4%) cytologically reported as malignant, five were histologically diagnosed as invasive carcinoma and one as carcinoma in situ. Overall, stereotaxic FNA cytology reported as malignant or probably malignant 14 of the 15 cases with a histologic confirmation of malignancy, for a sensitivity of 93.3%. Cytology correctly identified 78 of the 83 histologically negative cases, for a specificity of 94.0%. The 16 cases histologically diagnosed as ductal hyperplasia, which carries a high risk for subsequent malignancy, were studied in detail in an effort to define histologic and cytologic criteria for this entity. Using selected histologic criteria, 11 of these cases were graded as showing mild-to-moderate atypical hyperplasia and 5 as showing severe atypical hyperplasia. Three of the latter cases were similarly identified by an analogous cytologic grading; the other two cases had insufficient cytologic samples. The total results in this series of 114 cases support the use of stereotaxic FNA cytology in the diagnosis of these nonpalpable breast lesions, examples of which are illustrated. In particular, it may help to raise the low specificity yielded by mammography alone, which would represent a significant advance for the patient in terms of the accuracy, expediency and reduced cost of diagnosing these lesions.
Über 2‐substituierte Resorcindimethyläther (1967)

Abstract 2‐Lithium‐resorcindimethyläther ( 1 ) wird mit Halogenen, Pseudohalogenen, Alkylhalogeniden, Alkenylhalogeniden, Halogenäthern, Epoxiden, Aldehyden, Ketonen und Säurechloriden zu 2‐substituierten Resorcindimethyläthern umgesetzt; die Verbindungen werden charakterisiert.
Alpha-Soft Error Rate due to new generations of high-k gate oxides and metal gate electrodes in a 32 nm node (2011)

International audience
OMNIFOCALS — UNDERRATED AND UNDERUTILIZED (1972)

The author discusses his experience over the past three years with 80 patients for whom he prescribed Omnifocals. He points out five major areas where problems can occur and offers his solutions. Despite these problems, the many advantages outweigh the disadvantages; and he concludes that the Omnifocal is an excellent lens when properly prescribed for selected patients.
Ground states of fermionic lattice Hamiltonians with permutation symmetry (2013)

We study the ground states of lattice Hamiltonians that are invariant under permutations, in the limit where the number of lattice sites $N\ensuremath{\rightarrow}\ensuremath{\infty}$. For spin systems, these are product states, a fact that follows directly from the quantum de Finetti theorem. For fermionic systems, however, the problem is very different, since mode operators acting on different sites do not commute, but anticommute. We construct a family of fermionic states, $\mathcal{F}$, from which such ground states can be easily computed. They are characterized by few parameters whose number only depends on $M$, the number of modes per lattice site. We also give an explicit construction for $M=1,2$. In the first case, $\mathcal{F}$ is contained in the set of Gaussian states, whereas in the second it is not. Inspired by that construction, we build a set of fermionic variational wave functions, and apply it to the Fermi-Hubbard model in two spatial dimensions, obtaining results that go beyond the generalized Hartree-Fock theory.
Surface-Templated Nanobubbles Protect Proteins from Surface-Mediated Denaturation (2019)

In this Letter, we report that surface-bound nanobubbles reduce protein denaturation on methylated glass by irreversible protein shell formation. Single-molecule total internal reflection fluorescence (SM-TIRF) microscopy was combined with intramolecular Förster resonance energy transfer (FRET) to study the conformational dynamics of nitroreductase (NfsB) on nanobubble-laden methylated glass surfaces, using reflection brightfield microscopy to register nanobubble locations with NfsB adsorption. First, NfsB adsorbed irreversibly to nanobubbles with no apparent desorption after 5 h. Moreover, virtually all (96%) of the NfsB molecules that interacted with nanobubbles remained folded, whereas less than 50% of NfsB molecules remained folded in the absence of nanobubbles on unmodified silica or methylated glass surfaces. This trend was confirmed by ensemble-average fluorometer TIRF experiments. We hypothesize that nanobubbles reduce protein damage by passivating strongly denaturing topographical surface defects. Thus, nanobubble stabilization on surfaces may have important implications for antifouling surfaces and improving therapeutic protein storage.
Mechanisms of Action of Hypertonic Saline Resuscitation in Severe Sepsis and Septic Shock (2006)

Small volumes of 7.5% NaCl (2400mOsm/L) have been extensive evaluated in animal models of hemorrhagic shock and in clinical trials of post-traumatic hypotension and as volume support for complex cardiovascular procedures. Hypertonic solutions promote immediate blood volume expansion, restore cardiac output and regional blood flows, improve microcirculation and modulate immune responses, thereby decreasing inflammatory responses triggered by shock and trauma. A large number of very interesting in vivo and in vitro experiments highlighted that hypertonic saline resuscitation may decrease susceptibility to post-traumatic sepsis, modulate trauma and sepsis-induced immune dysfunction, inflammatory response and apoptosis. All those long-term benefits associated with hypertonic resuscitation may be of potential relevance for the management of severe sepsis and septic shock In this review, we describe the mechanisms of action of hypertonic saline based on experimental studies as well as its efficacy and safety based on its clinical use. We believe those studies support the need for additional experimental and clinical studies before the widespread use of hypertonic solutions for the treatment of severe sepsis and septic shock.