gebhart/patrepeval huggingface dataset:
Prognóza pacienta s ischemickou chorobou srdeční aneb na čem záleží (2020)

Doc. KovĂĄrnĂ­k rozebral ve svĂŠ pĹednĂĄĹĄce postupy ĹĂĄdnĂŠ prevence koronĂĄrnĂ­ch pĹĂ­hod u pacientĹŻ s ICHS. ZdĹŻraznil zejmĂŠna nutnost snĂ­ĹženĂ­ nadmÄrnĂŠ aktivace sympatoadrenĂĄlnĂ­ho systĂŠmu, kterou snadno identifikujeme podle zvĂ˝ĹĄenĂŠ tepovĂŠ frekvence a vysokĂŠho tlaku krve, a takĂŠ dosaĹženĂ­ nĂ­zkĂŠ hladiny LDL cholesterolu. Na mĂ­stÄ je lĂŠÄba inhibitory systĂŠmu RAAS a &#946;&#8209;blokĂĄtory spolu s podĂĄvĂĄnĂ­m statinĹŻ, popĹ. v kombinaci s ezetimibem a inhibitory PCSK9. Doc. KovĂĄrnĂ­k poukĂĄzal na ÄastĂŠ nedostateÄnĂŠ dĂĄvkovĂĄnĂ­ tÄchto pĹĂ­pravkĹŻ zjiĹĄtÄnĂŠ v ÄeskĂŠm prĹŻzkumu. DlouhodobĂŠ snĂ­ĹženĂ­ krevnĂ­ho tlaku a tepovĂŠ frekvence mĂĄ pĹitom pĹĂ­znivĂ˝ kumulativnĂ­ dopad na prognĂłzu pacientĹŻ s ICHS a dosaĹženĂĄ hladina LDL cholesterolu pod 1,8 mmol/l mĹŻĹže navodit dokonce regresi koronĂĄrnĂ­ aterosklerĂłzy. U pacientĹŻ po akutnĂ­m koronĂĄrnĂ­m syndromu s vysokĂ˝m rizikem ischemie a bez zvĂ˝ĹĄenĂŠho rizika krvĂĄcenĂ­ je pĹĂ­nosem takĂŠ dlouhodobĂĄ duĂĄlnĂ­ protidestiÄkovĂĄ lĂŠÄba. VysokĂ˝ poÄet pĹedepsanĂ˝ch tablet ke kaĹždodennĂ­mu uĹžĂ­vĂĄnĂ­ spolu s asymptomatiÄnostĂ­ rizikovĂ˝ch faktorĹŻ aterosklerĂłzy jsou pĹĂ­Äinou nĂ­zkĂŠ adherence pacientĹŻ k lĂŠÄbÄ. NedodrĹžovĂĄnĂ­ preventivnĂ­ lĂŠÄby mĂĄ prokĂĄzanĂ˝ vliv na vĂ˝skyt koronĂĄrnĂ­ch pĹĂ­hod a je vĂ˝znamnou pĹekĂĄĹžkou pĹi zlepĹĄovĂĄnĂ­ prognĂłzy pacientĹŻ s ICHS. Pacient by mÄl proto uĹžĂ­vat co nejniĹžĹĄĂ­ poÄet tablet, coĹž znamenĂĄ vysazenĂ­ medikace bez prokĂĄzanĂŠho pĹĂ­nosu a vyuĹžitĂ­ fixnĂ­ch kombinacĂ­.
Acoustic ink printing (2003)

An acoustic beam focused on a free liquid surface is used to eject discrete ink droplets of controlled diameter. The liquid surface, adjusted to be at the focal plane of a suitable focusing element, is excited with a burst of acoustic energy. Spherical lead zirconate titanate (PZT) shells, acoustic microscope lenses, spherical lenses etched in silicon, and Fresnel acoustic lenses are used successfully to eject droplets. Droplet diameter scales directly with the focal spot size, and inversely with the acoustic frequency. Droplet formation is experimentally demonstrated over the frequency range of 5 to 300 MHz, with corresponding droplet diameters from 300 to 5 mu m. This droplet ejection process is successfully utilized for a printing application by using ink as the liquid medium. Acoustic ink printing with a single lens and with an array of lenses is described.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Flagellin-rPAc vaccine inhibits biofilm formation but not proliferation ofS. mutans (2016)

As the main etiologic bacterium of dental caries, Streptococcus mutans (S. mutans) has been considered as the primary object of vaccine research. We previously constructed a recombinant flagellin-rPAc fusion protein (KF-rPAc) that consists of an alanine-rich region to proline-rich region fragment of PAc (rPAc) from S. mutans and flagellin KF from E.coli K12 strain. Intranasal (i.n) immunization of KF-rPAc could induce high level of rPAc-specific antibody responses and offer robust protection against dental caries. In caries development, biofilm formation was considered as the necessary process involved. As PAc possesses other activities besides affecting adherence of S. mutans to salivary glycoproteins, we wondered whether rPAc-specific antibody responses induced by KF-rPAc could inhibit biofilm formation. Hence, in the present study, a simple and convenient in vitro biofilm model of S. mutans was constructed without saliva pre-coated. Both serum and saliva from KF-rPAc immunized rats significantly inhibited biofilm formation. Moreover, with the presence of serum or saliva, the biofilm formation is negatively correlated with the level of rPAc-specific antibody, and positively correlated with caries scores in rat. Moreover, in immunized mice, the level of rPAc-specific antibody also negatively correlated with the biofilm formation. Unlike ampicillin, serum of KF-rPAc immunized mice only inhibited biofilm formation but not proliferation. All together, we discovered that besides the well known blocking adherence of S. mutans to salivary glycoproteins by rPAc-specific antibody, flagellin-rPAc vaccine could also protects tooth from caries by inhibiting biofilm structure formation in between bacteria.
AxCEM: Designing Approximate Comparator-Enabled Multipliers (2020)

Floating-point multipliers have been the key component of nearly all forms of modern computing systems. Most data-intensive applications, such as deep neural networks (DNNs), expend the majority of their resources and energy budget for floating-point multiplication. The error-resilient nature of these applications often suggests employing approximate computing to improve the energy-efficiency, performance, and area of floating-point multipliers. Prior work has shown that employing hardware-oriented approximation for computing the mantissa product may result in significant system energy reduction at the cost of an acceptable computational error. This article examines the design of an approximate comparator used for preforming mantissa products in the floating-point multipliers. First, we illustrate the use of exact comparators for enhancing power, area, and delay of floating-point multipliers. Then, we explore the design space of approximate comparators for designing efficient approximate comparator-enabled multipliers (AxCEM). Our simulation results indicate that the proposed architecture can achieve a 66% reduction in power dissipation, another 66% reduction in die-area, and a 71% decrease in delay. As compared with the state-of-the-art approximate floating-point multipliers, the accuracy loss in DNN applications due to the proposed AxCEM is less than 0.06%.
Metabolic control and structure of glycolytic enzymes. VI. Competitive inhibition of yeast glyceraldehyde 3-phosphate dehydrogenase by cyclic adenosine monophosphate, adenosine triphosphate, and other adenine-containing compounds (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetabolic control and structure of glycolytic enzymes. VI. Competitive inhibition of yeast glyceraldehyde 3-phosphate dehydrogenase by cyclic adenosine monophosphate, adenosine triphosphate, and other adenine-containing compoundsShih Tzy Yang and W. C. Deal Jr.Cite this: Biochemistry 1969, 8, 7, 2806–2813Publication Date (Print):July 1, 1969Publication History Published online1 May 2002Published inissue 1 July 1969https://pubs.acs.org/doi/10.1021/bi00835a017https://doi.org/10.1021/bi00835a017research-articleACS PublicationsRequest reuse permissionsArticle Views505Altmetric-Citations76LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Probabilistic Kernel Regression Models (1999)

We introduce a class of flexible conditional probability models and techniques for classification /regression problems. Many existing methods such as generalized linear models and support vector machines are subsumed under this class. The flexibility of this class of techniques comes from the use of kernel functions as in support vector machines, and the generality from dual formulations of standard regression models. 1 Introduction Support vector machines [10] are linear maximum margin classifiers exploiting the idea of a kernel function. A kernel function defines an embedding of examples into (high or infinite dimensional) feature vectors and allows the classification to be carried out in the feature space without ever explicitly representing it. While support vector machines are non-probabilistic classifiers they can be extended and formalized for probabilistic settings[12] (recently also [8]), which is the topic of this paper. We can also identify the new formulations with other s...
Notice of Removal: SO2 quantification of rat HCC tumors using fluence-corrected photoacoustic imaging (2017)

Removed.
Probabilistic Model‐Based Cell Tracking (2006)

The study of cell behavior is of crucial importance in drug and disease research. The fields of bioinformatics and biotechnology rely on the collection, processing, and analysis of huge numbers of biocellular images, including cell features such as cell size, shape, and motility. However manual methods of inferring these values are so onerous that automated methods of cell tracking and segmentation are in high demand. In this paper, a novel model-based cell tracker is designed to locate and track individual cells. The proposed cell tracker has been successfully applied to track hematopoietic stem cells (HSCs) based on identified cell locations and probabilistic data association.
Refractive error and visual outcome after cataract extraction (2002)

These data provide benchmark information that can be used to monitor clinical practice.
Analytic$I_{\text{sc}}$–$V_{\text{oc}}$ Method and Power Loss Modes From Outdoor Time-Series $I$–$V$ Curves (2020)

Utilizing large-scale outdoor I-V data streams, the authors demonstrated a feasible, repeatable method to construct outdoor time-series I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">sc</sub> -V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">oc</sub> curves. Resulting Analytic I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">sc</sub> -V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">oc</sub> curves are validated with laboratory Suns-V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">oc</sub> measurements. Comparing I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">sc</sub> -V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">oc</sub> with real I-V curves, power loss modes including uniform current loss, recombination loss, series resistance loss, and current mismatch loss can be quantified in units of watts or percent nominal power, making them directly comparable. Above power loss modes are calculated for long-term I-V data from fielded modules in different climate zones, and dominant power loss modes were determined from the resulting time series. This method has been published as an open source package in R programming language.
A practically implementable and tractable delegation logic (2002)

We address the goal of making Delegation Logic (DL) into a practically implementable and tractable trust management system. DL (N. Li et al., 1999) is a logic based knowledge representation (i.e., language) for authorization in large scale, open, distributed systems. DL inferencing is computationally intractable and highly impractical to implement. We introduce a new version of Delegation Logic that remedies these difficulties. To achieve this, we impose a syntactic restriction and redefine the semantics somewhat. We show that, for this revised version of DL, inferencing is computationally tractable under the same commonly met restrictions for which Ordinary Logic Programs (OLP) inferencing is tractable (e.g., Datalog and bounded number of logical variables per rule). We give an implementation architecture for this version of DL; it uses a delegation compiler from DL to OLP and can modularly exploit a variety of existing OLP inference engines. As proof of concept, we have implemented a large expressive subset of this version of DL, using this architecture.
A chondrogenic gene expression signature in mesenchymal stem cells is a classifier of conventional central chondrosarcoma (2008)

Phenotypic and molecular parallels between the development of chondrosarcoma and the differentiation of chondrocytes in normal growth plate suggest that chondrosarcoma may arise from mesenchymal precursor cells driven towards chondrogenesis. We hypothesized that a comparison between cartilaginous tumours and their possible physiological cells of origin, mesenchymal stem cells (MSCs), might have biological and clinical relevance. MSCs from eight donors were submitted to chondrogenic differentiation in spheroid cultures. Expression profiles of MSCs at days 0, 7, 14, 28 and 42 of chondrogenesis and of 18 chondrosarcomas with different histological grades were studied using a customized cDNA array. Hierarchical clustering of MSC gene expression during chondrogenesis allowed the classification of samples in a pre-chondrogenic and a chondrogenic cluster corresponding to the phenotypes of early and late differentiation stages. The 74 genes differentially expressed between the two clusters were defined as chondrogenesis-relevant genes. Gene expression profiles of chondrosarcoma were submitted to hierarchical clustering on the basis of these chondrogenesis-relevant genes. This analysis allowed clear distinction between grade I and grade III chondrosarcoma and separated grade II chondrosarcoma into two groups. All grade II chondrosarcomas with occurrence of metastasis were found together with the grade III chondrosarcomas in the pre-chondrogenic cluster. This analysis shows that a molecular approach based on the comparison of tumour samples to an in vitro model for chondrogenic differentiation allows a new classification of chondrosarcoma in two clusters. These data suggest that the identification of a pre-chondrogenic and a chondrogenic phenotype for chondrosarcoma by gene expression profiling could develop into a useful tool to predict the clinical behaviour of chondrosarcoma.
Ductility of bulk nanocrystalline composites and metallic glasses at room temperature (2000)

Mechanical properties of bulk Zr60Cu20Pd10Al10 nanocrystalline composite and Zr55Ni5Cu30Al10 metallic glass were measured by compression tests at room temperature. The Zr60Cu20Pd10Al10 as-quenched alloy obviously exhibits plastic strain while no distinct plastic deformation is recognized in the Zr55Ni5Cu30Al10 metallic glass. Moreover, the plastic strain increased by increasing the volume fraction of nanocrystals and achieved maximum value in the early stage of the nanocrystallization. High-resolution electron microscopy showed that, different from the microstructure of Zr55Ni5Cu30Al10 metallic glass, nanocrystals with main grain sizes of about 2 nm were embedded in the amorphous matrix of the bulk Zr60Cu20Pd10Al10 alloy which showed the maximum plastic strain.
Mesenchymal Stem Cells Neuronal Differentiation Ability: A Real Perspective for Nervous System Repair? (2011)

Mesenchymal Stem Cells (MSCs) are a bone marrow-derived population present in adult tissues that possess the important property of dividing when called upon and of differentiating into specialized cells. The evidence that MSCs were able to transdifferentiate into specialized cells of tissues different from bone marrow, in particular into nervous cells, opened up the possibility of using MSCs to substitute damaged neurons, that are normally not replaced but lost, in order to repair the Nervous System. The first neuronal differentiation protocols were based on the use of a mixture of toxic drugs which induced MSCs to rapidly acquire a neuronal-like morphology with the expression of specific neuronal markers. However, many subsequent studies demonstrated that the morphological and molecular modifications of MSCs were probably due to a stress response, rather than to a real differentiation into neuronal cells, thus throwing into question the possible use of MSCs to repair the nervous system. Currently, some papers are suggesting again that it may be possible to induce neuronal differentiation of MSCs by using several differentiation protocols, and by accompanying the morphological evidence of differentiation with functional evidence, thus demonstrating that MSC-derived cells not only seem to be neurons, but that they also function like neurons. In this review, we have attempted to shed light on the capacity of MSCs to genuinely differentiate into nervous cells, and to identify the most reliable protocols for obtaining neurons from MSCs for nervous system repair.
Control of Chaos and Separation of Particles in Inertia Ratchets (2005)

We have studied the deterministic dynamics of underdamped single and multiparticle ratchets associated with current reversal, as a function of both the amplitude and the frequency of an external driving force. We show that control of current reversals in deterministic inertia ratchets is possible as a consequence of a locking process associated with di erent mean velocity attractors. Control processes employing small perturbations on the frequency and the amplitude of the external force may be designed in view of the intermixed fractal nature of the domains of attraction of the mean velocity attractors. The range where each control parameter is capable to reverse the current is determined. The presence of quenched noise and the influence of the mass of the particle is also considered in order to design control techniques capable of separating particles of di erent masses.
Click‐Tag and Amine‐Tag: Chemical Tag Approaches for Efficient Protein Labeling In Vitro and on Live Cells using the Naturally Split Npu DnaE Intein (2014)

Protein labeling with synthetic moieties remains in many cases a technically challenging or unresolved task. Two new and simple concepts are presented. In both approaches, a very short tag of only a few amino acids is prepared with the desired chemical modification and, in a second step, it is transferred to the protein of interest by protein trans-splicing. For the amine-tag, a recombinant intein fragment free of lysine residues was generated such that the amine group of the N terminus could be selectively modified with regular amine-reactive reagents. Thus, standard bioconjugation procedures without any chemical synthesis could be applied without modification of lysines in the protein of interest. For the click-tag, protein trans-splicing was combined with unnatural amino acid mutagenesis and subsequent bioorthogonal side chain modification, as demonstrated for click chemistry using p-azidophenylalanine. By the two-step strategy, exposure of the protein of interest to the copper catalyst was avoided.
Condensin I-mediated mitotic chromosome assembly requires association with chromokinesin KIF4A (2016)

The chromokinesin KIF4A has been implicated in shaping mitotic chromosomes, but its functional relationship to condensin complexes remains controversial. Here, we found that, in mitosis, KIF4A associates with condensin I but not with condensin II. Mutational analyses indicated that the enrichment of condensin I to chromosomal axes depends on its association with KIF4A in a way that likely involves its motor activity. Remarkably, this interaction is required for condensin I to confer physiological properties to chromosomes. These observations provide an insight into how condensin I is enriched at chromosomal axes and underscore the significance of axial structure in organizing mitotic chromosomes.
Hearing and Sjögren's Syndrome (1996)

Immune sensorineural hearing loss is manifested in several systemic immune diseases. Although hearing loss has been previously documented in patients with Sjögren's syndrome (SS), the effect of SS on hearing is unclear. This prospective study was designed to assess the presence of hearing loss in 14 patients with SS and, if sensorineural hearing loss was present, to determine if the hearing loss was immune-mediated. Patients were evaluated with basic audiologic tests as well as for cellular immune inner ear reactivity as measured by the lymphocyte transformation test (LTT). Three patients had evidence of sensorineural hearing loss. Two patients had a positive LTT without evidence of sensorineural hearing loss. This preliminary study suggests that SS may not directly cause sensorineural hearing loss, immuno-mediated or otherwise.
Underwater Self-Healable Materials for Sensing Applications (2022)

TEST 02 - Elsevier's Scopus, the largest abstract and citation database of peer-reviewed literature. Search and access research from the science, technology, medicine, social sciences and arts and humanities fields.
Endoscopic Surgery for Breast Cancer (2008)

乳腺内視鏡手術は内視鏡手術手技により手術創の縮小化と移動を実現し整容性と手術効果の両面を満足させることができる乳房温存手術であり，日本で独自に開発された術式である．各術式は腋窩アプローチ法，傍乳輪アプローチ，外側アプローチ法，乳房下アプローチ法に分類され，それぞれ完全内視鏡手術と内視鏡補助手術が行われている．腫瘍径 2 cm 以上では何らかの乳房の変形が生じるため再建術の併用が必要と思われた．当科では現在セルロース，コラーゲンによる充填法を施行しており良好な成績を得ている．乳腺内視鏡手術は無作為比較試験による直接的証明はされていないものの従来法と同等の手術効果と安全性を持ちかつ整容性の面では優れている事から今後の普及が期待される術式である．しかしその最大の目的である整容性を保持するためには厳格に適応を守り，内視鏡手術特有の合併症について十分な対策を立てておく必要がある．
Arabic Phonemes Transcription using Data Driven Approach (2015)

The efficiency and correctness of continuous Arabic Speech Recognition Systems (ARS) hinge on the accuracy of the language phoneme set. The main goal of this research is to recognize and transcribe Arabic phonemes using a data-driven approach. We used the Hidden Markov Toolkit (HTK) to develop a phoneme recognizer, carrying out several experiments with different parameters, such as varying number of Hidden Markov Model (HMM) states and Gaussian mixtures to model the Arabic phonemes and find the best configuration. We used a corpus consisting of about 4000 files, representing 5 recorded hours of Modern Standard Arabic (MSA) of TV-News. A statistical analysis for the phonemes length, frequency and mode was carried out, in order to determine the best number of states necessary to represent each phoneme. Phoneme recognition accuracy of 56.79% was reached without using a language model. The recognition accuracy increased to 96.3% upon using a bigram language model.
The use of chymopapain in degenerative disc disease: a preliminary report. (1970)

On the basis of the early results of the use of intradiscal injection of chymopapain in 15 patients with degenerative lumbar disc disease, the following statements are warranted: The injection can be beneficial in selected patients with lumbar disc disease. The relief of leg symptoms seems to be more striking than that of the accompanying low back symptoms although both are apparent. The exact mechanism by which pain is relieved is still obscure, but helpful information has been obtained from the early results of this investigation. The failure of chymopapain in carefully selected patients has resulted in only a brief time delay in operative intervention.
Holographic navigation (2008)

This paper presents a method for navigating relative to the sea floor using sonar imagery. The aspect dependent terrain recognition problem is addressed by generating acoustic holograms of the sea floor containing images of all aspects of interest. Grazing angle compensation is applied to reduce the required spatial sampling from planar to linear. Sonar images are coherently correlated with centimeter resolution to provide navigational updates. The technique is demonstrated using five short duration missions in St. Andrew Bay and three long duration missions, with a combined extent of 69.7 km, in the Gulf of Mexico.