gebhart/patrepeval huggingface dataset:
Long-term prognosis of AL amyloidosis in patients treated with bortezomib or thalidomide (2023)

Abstract Introduction AL amyloidosis has become a common secondary cause in elderly male patients presenting with nephrotic syndrome. Daratumumab-CyBorD regimen is approved as the standard first-line regimen for AL-amyloidosis. We aim to analyze the prognosis of patients treated with bortezomib-based regimen and other alternative regimens. Method We retrospectively collected the baseline and follow up data of newly diagnosed AL amyloidosis patients. Hematological and renal response rate were compared among different regimens and overall survival and renal survival were analyzed. Subgroup analysis of Mayo stage III patients was also performed. Results 72 cases were included, 48.6% of whom had cardiac involvement. Overall response rate in patients treated with bortezomib-based regimen was 67.4%, including 27.9% complete response (CR). Renal outcomes such as proteinuria response rate and incidence of end stage renal disease (ESRD) were not different between bortezomib and thalidomide-based therapy.Median follow up for whole cohort was 22 months,and 13(18.1%) patients died at the end of follow-up, while 7 patients(9.7%) progressed to dialysis. Median overall survival (OS) was not reached in both regimens and 1 year survival rates were 90.4% and 80.0% respectively in bortezomib and thalidomide based therapy( P = 0.127). Patients treated with bortezomib-based treatment had longer organ deterioration progression-free survival (MOD-PFS).There was no difference in response rate and OS between patients treated with cyclophosphamide, bortezomib,dexamethasone(CVD) and bortezomib, dexamethasone (VD). Mayo stage III patients who were treated with VD regimen had longer OS compared with TD or CTD regimen. Conclusion Bortezomib-based regimen had high efficacy in promoting rapid hematologic responses and reducing the risk of major organ deterioration in AL amyloidosis, which was also effective among patients with cardiac insufficiency. Addition of cyclophosphamide into VD regimen could not further improve the overall remission or survival of AL amyloidosis.
PANTOTHENIC AND NICOTINIC ACIDS AS GROWTH FACTORS FOR LACTIC ACID BACTERIA (1938)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPANTOTHENIC AND NICOTINIC ACIDS AS GROWTH FACTORS FOR LACTIC ACID BACTERIAEsmond E. Snell, Frank M. Strong, and William H. PetersonCite this: J. Am. Chem. Soc. 1938, 60, 11, 2825Publication Date (Print):November 1, 1938Publication History Published online1 May 2002Published inissue 1 November 1938https://pubs.acs.org/doi/10.1021/ja01278a520https://doi.org/10.1021/ja01278a520research-articleACS PublicationsRequest reuse permissionsArticle Views79Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Primary Epstein‐Barr Virus Infection with Pneumonia Transmitted by Allogeneic Bone Marrow after Transplantation (2006)

We report a case of primary Epstein-Barr virus infection with lung involvement occurring 1 month after bone marrow transplantation. The transplant recipient had serological test results that were negative for Epstein-Barr virus before transplantation. The virus must have been transmitted by the donor's bone marrow, which was positive for Epstein-Barr virus. The patient recovered after rituximab and corticosteroid therapy.
Decision support system for treatment selection: Application of a statistical expert advisor to the problem of prostate cancer treatment selection (1993)

Abstract For clinical cases with difficult combinations of patient parameter values, treatment selection may be complex or controversial and require considerable time. Treatment selection may be affected by a clinician's experience with a disease and expertise with a treatment, existing protocols, capabilities of local medical facilities, and patient preference. We discuss the concepts and clinical applications of an interactive statistical package (isp) software shell which can create systems that reproduce the judgment of one or more expert clinicians in the management of a patient. An isp system can 1) be taught, verified, updated, and tailored to local facilities quickly and easily by an individual clinician, 2) compute and rank treatment selection probabilities for a presented case in accord with the treatment preferences of its human teacher and explain to a clinician the logical and statistical basis of each step of the decision process, 3) identify sensitive variables of a case for additional verification and to allow questions of the type “what would be the treatment preferences if the value of this variable were changed?”, 4) accumulate statistics for unusual cases (rare combinations of patient parameter values), and 5) continue to learn and achieve further (statistical) insight by recognizing variable combinations (joint variables) whose values are more sensitive to the selection of a particular treatment. An isp system can be used for 1) second opinions, by estimating the treatment preferences of one or more clinical experts for a particular case, 2) allowing patient involvement in the treatment decision in cases for which several treatment options may provide the same outcome, 3) quality assurance, by helping a clinician to identify and review critical patient parameter values and pivotal questions, and to check a treatment decision with his own isp system and those of colleagues, 4) avoiding unnecessary diagnostic tests, by identifying parameters that do not affect the treatment selection for a case, 5) documenting the decision factors of a case, 6) finding the reasons for differences among experts in treatment selection for different types of cases, and 7) teaching residents. The concepts and clinical application of an isp system are discussed. © 1993 Wiley‐Liss, Inc.
Exploration of the compositional space for mixed lead halogen perovskites for high efficiency solar cells (2016)

A systematic investigation of the compositional space for perovskite solar cells spanned by MAPbI<sub>3</sub>, MAPbBr<sub>3</sub>, FAPbI<sub>3</sub>and FAPbBr<sub>3</sub>.
Vehicle control using preview information (2006)

The background and the aim of the project,“Vechicle control by using preview information - ’Look Ahead’ ” , are discussed. The project is raisedto explore the possibilities of reduction of fuel consumption and improvements in comfort and safety for heavy vehicles. In particular research will focus on improvements that can be made, in actual and future control systems, with knowledge of the road ahead. This paper describes the project and reports on initial findings as well as related research.
Bone morphogenetic protein 9 as a key regulator of liver progenitor cells in DDC‐induced cholestatic liver injury (2018)

We identify BMP9 as a negative regulator of oval cell expansion in cholestatic injury, its deletion enhancing liver regeneration. Likewise, our work further supports BMP9 as an attractive therapeutic target for chronic liver diseases.
Triboelectric nanogenerator as a new technology for effective PM2.5 removing with zero ozone emission (2018)

Particles matters (PMs) have raised serious concerns due to their great impact on human health. Coupling triboelectric effect and electrostatic induction, triboelectric nanogenerator (TENG) has demonstrated as a practical sustainable power source for portable devices. The characteristics of TENG, such as high electric field and high output power, make it a promising technology in air cleaning applications. Here, the mechanism of the TENG and its application in self-powered air cleaning technologies are reviewed. Using the TENG as a voltage source, a self-powered air cleaning system for removing SO2 and PMs is developed; and the removal efficiency of nanofiber filters is greatly enhanced due to electrostatic attraction. More importantly, the technology is not only most effective for removing nano-scale particles that cannot be effectively filtered using conventional fiber-film filters, but also produces no ozone emission. Besides being an independent power supply, a vibration TENG based triboelectric filter is designed to effectively capture the PMs from automobile exhaust fumes. Hence, the TENG demonstrates its great potential in self-powered air cleaning applications. Keywords: Triboelectric nanogenerator, Power source, Particulate matter, Air cleaning, Nanofiber filter
J0405-1-2 Lead-Wire Integrated Electrodes by Electrical Plating for Electrical Resistance Change Method to Monitor Damage of CFRP laminates (2009)

For Carbon Fiber Reinforced Plastic (CFRP), electrical conductivity of carbon fiber can be used as a sensor for damage detection. The change of electrical resistance of the CFRP structure has been studied as a self-sensing system for monitoring damages. Todoroki et al. reported that the electrical resistance change method successfully monitored various damages like matrix cracking, fiber breakage and delamination in CFRP laminates. To apply the electrical resistance change method to practical structures, reliability of the electrodes is a key issue. This paper contains the proposal of "Lead-Wire Integrated Electrodes" and the investigation of the reliability of the proposed electrodes under cyclic load. The electrodes were bonded to CFRP surface by using copper plating after polishing of the specimen surface with sandpaper to remove the surface resin. Lead-Wire was put on the electrode and bonded to the electrode by using copper plating. This proposed electrode is no initial defect. The specimen for this experiment was made of unidirectional CFRP prepreg. Volume fraction of specimens used for the fatigue test was almost 65%. Fatigue tests were carried out using a servo-hydraulic testing system. As a result, the electrodes had a fatigue life at the same level as the conventional strain gages under cyclic load.
Ridge regression and Kalman filtering for target tracking in wireless sensor networks (2014)

This paper introduces an original method for target tracking in wireless sensor networks that combines machine learning and Kalman filtering. A database of radio-fingerprints is used, along with the ridge regression learning method, to compute a model that takes as input RSSI information, and yields, as output, the positions where the RSSIs are measured. This model leads to a position estimate for each target. The Kalman filter is used afterwards to combine the model's estimates with predictions of the target's positions based on acceleration information, leading to more accurate ones.
Dancing around the divisome: asymmetric chromosome segregation in Escherichia coli (2005)

By simultaneously tracking pairs of specific genetic regions and divisome proteins in live Escherichia coli, we develop a new scheme for the relationship between DNA replication-segregation, chromosome organization, and cell division. A remarkable asymmetric pattern of segregation of different loci in the replication termination region (ter) suggests that individual replichores segregate to distinct nucleoid positions, consistent with an asymmetric segregation of leading and lagging strand templates after replication. Cells growing with a generation time of 100 min are born with a nonreplicating chromosome and have their origin region close to mid-cell and their ter polar. After replication initiation, the two newly replicated origin regions move away from mid-cell to opposite cell halves. By mid-S phase, FtsZ forms a ring at mid-cell at the time of initiation of nucleoid separation; ter remains polar. In the latter half of S phase, ter moves quickly toward mid-cell. FtsK, which coordinates the late stages of chromosome segregation with cell division, forms a ring coincident with the FtsZ ring as S phase completes, approximately 50 min after its initiation. As ter duplicates at mid-cell, sister nucleoid separation appears complete. After initiation of invagination, the FtsZ ring disassembles, leaving FtsK to complete chromosome segregation and cytokinesis.
Frizzled Proteins are bona fide G Protein-Coupled Receptors (2009)

Abstract Receptors of the Frizzled family initiate Wnt ligand-dependent signaling controllingmultiple steps in organism development and highly conserved in evolution.Misactivation of the Wnt/Frizzled signaling is cancerogenic. Frizzled receptorslaunch several signaling cascades: the canonical pathway regulating beta-catenin-dependent transcription; the planar cell polarity pathway polarizing thecytoskeleton within the epithelial plane; and the calcium pathway. Frizzledreceptors possess seven transmembrane domains and their signaling depends ontrimeric G proteins in various organisms. However, Frizzleds constitute adistinct group within the G protein-coupled receptors (GPCR) superfamily, andFrizzled signaling can be G protein-independent in some experimental setups, which led to concerns about the GPCR nature of Frizzled. Here we demonstratethat human Frizzled receptors can directly bind the trimeric Go protein in apertussis toxin-sensitive manner. Furthermore, addition of Wnt ligands elicitsFrizzled-dependent guanine nucleotide exchange on Go. An excess of secretedFrizzled-related protein (a Wnt antagonist) prevents Go activation, as doespretreatment of Go with pertussis toxin. These experiments provide a biochemicalproof of the GPCR activities of Frizzled receptors and establish an in vitro assay tomonitor Frizzled activation by Wnt ligands, applicable for the high-throughputagonist/antagonist screening.
Fabrication and Closure Development of Corrosion Resistant Containers for Nevada’s Yucca Mountain High-Level Nuclear Waste Repository (1990)

Abstract U.S. Congress and the President have determined that the Yucca Mountain site in Nevada is to be characterized to determine its suitability for construction of the first U.S. high-level nuclear waste repository. Work in connection with this site is carried out within the Yucca Mountain Project (YMP). Lawrence Livermore National Laboratory (LLNL) has the responsibility for designing, developing, and projecting the performance of the waste package for the permanent storage of high-level nuclear waste. Babcock &amp; Wilcox (B&amp;W) is involved with the YMP as a subcontractor to LLNL. B&amp;W's role is to recommend and demonstrate a method for fabricating the metallic waste container and a method for performing the final closure of the container after it has been filled with waste. Various fabrication and closure methods are under consideration for the production of containers. This paper presents progress to date in identifying and evaluating the candidate manufacturing processes.
Mosquirix™ RTS, S/AS01 Vaccine Development, Immunogenicity, and Efficacy (2022)

Malaria is a parasitic infection caused by bites from <i>Plasmodium falciparum</i> (<i>P</i>. <i>falciparum</i>)-infected mosquitoes with a present scale of symptoms ranging from moderate fever to neurological disorders. <i>P. falciparum</i> is the most lethal of the five strains of malaria, and is a major case of morbidity and mortality in endemic regions. Recent advancements in malaria diagnostic tools and prevention strategies have improved conjugation antimalarial therapies using fumigation and long-lasting insecticidal sprays, thus lowering malarial infections. Declines in the total number of infected individuals have been correlated with antimalarial drugs. Despite this, malaria remains a major health threat, affecting more than 30 million men, women, and children around the globe, and 20 percent of all children around the globe have malaria parasites in their blood. To overcome this life-threatening condition, novel therapeutic strategies, including immunization, are urgently needed to tackle this infection around the world. In line with this, the development of the RTS, S vaccine was a significant step forward in the fight against malaria. RTS, S is a vaccine for <i>P. falciparum</i> in which R specifies central repeat units, T the T-cell epitopes, and S indicates surface antigen. The RTS, S/AS01 malarial vaccine was synthesized and screened in several clinical trials between 2009 and 2014, involving thousands of young children in seven African countries, showing that children who received the vaccine did not suffer from severe malaria. Mosquirix™ was approved by the World Health Organization in 2021, indicating it to be safe and advocating its integration into routine immunization programs and existing malaria control measures. This paper examines the various stages of the vaccine's development, including the evaluation of its immunogenicity and efficacy on the basis of a total of 2.3 million administered doses through a routine immunization program. The protection and effectiveness provided by the vaccine are strong, and evidence shows that it can be effectively delivered through the routine child immunization platform. The economic cost of the vaccine remains to be considered.
An UV photochromic memory effect in proton-based WO3 electrochromic devices (2008)

We report an UV photochromic memory effect on a standard proton-based WO3 electrochromic device. It exhibits two memory states, associated with the colored and bleached states of the device, respectively. Such an effect can be used to enhance device performance (increasing the dynamic range), re-energize commercial electrochromic devices, and develop memory devices.
Frequency and voltage-dependent electrical and dielectric properties of Al/Co-doped PVA/p-Si structures at room temperature (2014)

In order to investigate of cobalt-doped interfacial polyvinyl alcohol (PVA) layer and interface trap (D-it) effects, Al/pSi Schottky barrier diodes (SBDs) are fabricated, and their electrical and dielectric properties are investigated at room temperature. The forward and reverse admittance measurements are carried out in the frequency and voltage ranges of 30 kHz-300 kHz and -5 V-6 V, respectively. C-V or epsilon '-V plots exhibit two distinct peaks corresponding to inversion and accumulation regions. The first peak is attributed to the existence of Dit, the other to the series resistance (R-s), and interfacial layer. Both the real and imaginary parts of dielectric constant (epsilon ' and epsilon '') and electric modulus (M ' and M ''), loss tangent (tan delta), and AC electrical conductivity (sigma(ac)) are investigated, each as a function of frequency and applied bias voltage. Each of the M ' versus V and M '' versus V plots shows a peak and the magnitude of peak increases with the increasing of frequency. Especially due to the Dit and interfacial PVA layer, both capacitance (C) and conductance (G/w) values are strongly affected, which consequently contributes to deviation from both the electrical and dielectric properties of Al/Co-doped PVA/p-Si (MPS) type SBD. In addition, the voltage-dependent profile of Dit is obtained from the low-high frequency capacitance (CLF-CHF) method.
VOLUNTEER WHEEL RUNNING IS NOT AS EFFECTIVE IN DEMONSTRATING AEROBIC TRAINING EFFECTS AS FORCED SWIMMING IN THE OVARIECTOMIZED, RETIRED-BREEDER RAT (2001)

We assessed the differences in aerobic training effects between 6 weeks of forced swimming and voluntary wheel running in ovariectomized (ovx), retired breeder rats and made comparisons to sham-operated (SH) sedentary controls (n = 9). Ovariectomized rats were divided into three groups (n = 9, 10, and 9, respectively): sedentary control (ovx-C); swimmers (ovx-S); and wheel-runners (ovx-R). Swimming consisted of increasing duration to 60 minutes by the end of week two. Wheels were attached to ovxR cages with free access. All rats were fed a typical AIN-93M rat chow diet and water ad libitum. Heart, dissectable abdominal fat, and skeletal muscles (L/R quadriceps, gastrocnemius, soleus, triceps) were weighed at the end of the study. There was a non-significant increase in heart weights for swimmers and runners over sham-and ovx-controls; but ovx-S had a higher heart-to-body weight ratio than ovx-R (p < 0.05) and ovx-C (p < 0.01). Swimmers had the lowest abdominal fat weights of all groups, but only reached significance with the sham-C group (p < 0.05). There were no differences in individual muscle weights among groups. Citrate synthase activity of the soleus muscle was higher in both ovx-R and ovx-S than the SH (p < 0.01), but only ovx-S was significantly higher than ovxC (p < 0.05). The final body weights of the animals in the ovx-R group were significantly higher than those in the SH and ovx-S groups, but not the ovx-C group. In conclusion, voluntary wheel running was not as effective as 60 minutes of forced swimming as an aerobic training tool in the ovariectomized, retired breeder rat.
Differentiation of snake venom using Raman spectroscopic analysis (2023)

Snake venoms are complex mixtures of different substances, proteins being their predominant components. To study the composition of venoms, methods based on chromatographic separation and mass spectrometric analysis are currently used, requiring the application of a number of sophisticated instruments. To assess the composition of snake venoms, we propose an alternative method based on Raman spectroscopy, which is an express method to study the structural features of different substances, including proteins. The method does not require preliminary preparation of the samples, which are used in small quantities; this makes Raman spectroscopy extremely attractive for venom research. In this work, we have carried out Raman spectroscopic studies on a number of dry venoms from various venomous snakes. Based on the obtained Raman spectra, with the help of mathematical methods of dimensionality reduction and clustering, differentiation of venoms reflecting their composition and the assignment of the venom producing snake to the corresponding family or even genus were performed. The proposed method can be used to analyze both the composition of and variations in venoms of different snake species, including rare and endangered ones.
Separable Bilateral Filtering for Fast Video Preprocessing (2005)

Bilateral filtering is an edge-preserving filtering technique that employs both geometric closeness and photometric similarity of neighboring pixels to construct its filter kernel. Multi-dimensional bilateral filtering is computationally expensive because the adaptive kernel has to be recomputed at every pixel. In this paper, we present a separable implementation of the bilateral filter. The separable implementation offers equivalent adaptive filtering capability at a fraction of execution time compared to the traditional filter. Because of this efficiency, the separable bilateral filter can be used for fast preprocessing of images and videos. Experiments show that better image quality and higher compression efficiency is achievable if the original video is preprocessed with the separable bilateral filter.