gebhart/patrepeval huggingface dataset:
Microstructure and electrical properties of Ge- and Si-nanoclusters in implanted gate oxide for embedded memory applications (2003)

MOSFETs with gate oxides containing nanoclusters (Si,Ge) fabricated with different techniques (implantation, LPCVD, sputtering) are a very promising approach for future memories. This contribution reports on results obtained on Si- or Ge-implanted MOS capacitors and transistors. By varying the implantation and annealing parameters the Si or Ge depth profile and the cluster size and distribution can be controlled. The experimental results are explained by a theoretical model, which is based on TRIM calculations, rate-equation studies and 3D kinetic Monte Carlo simulations. The electrical properties of gate-SiO/sub 2/ containing Si- or Ge-nanoclusters are investigated in detail with emphasis on its feasibility for embedded memories for system on chip applications.
Forensic Environmental Science: Where Laws and Ecological Principles Meet (2006)

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Resistance Mechanisms to Targeted Therapies in ROS1 + and ALK + Non–small Cell Lung Cancer (2018)

<b>Purpose:</b> Despite initial benefit from tyrosine kinase inhibitors (TKIs), patients with advanced non-small cell lung cancer (NSCLC) harboring <i>ALK</i> (ALK<sup>+</sup>) and <i>ROS1</i> (ROS1<sup>+</sup>) gene fusions ultimately progress. Here, we report on the potential resistance mechanisms in a series of patients with ALK<sup>+</sup> and ROS1<sup>+</sup> NSCLC progressing on different types and/or lines of <i>ROS1/ALK</i>-targeted therapy.<b>Experimental Design:</b> We used a combination of next-generation sequencing (NGS), multiplex mutation assay, direct DNA sequencing, RT-PCR, and FISH to identify fusion variants/partners and copy-number gain (CNG), kinase domain mutations (KDM), and copy-number variations (CNVs) in other cancer-related genes. We performed testing on 12 <i>ROS1<sup>+</sup></i> and 43 <i>ALK<sup>+</sup></i> patients.<b>Results:</b> One of 12 ROS1<sup>+</sup> (8%) and 15 of 43 (35%) ALK <i><sup>+</sup></i> patients harbored KDM. In the ROS1<sup>+</sup> cohort, we identified <i>KIT</i> and β-catenin mutations and HER2-mediated bypass signaling as non-ROS1-dominant resistance mechanisms. In the ALK<sup>+</sup> cohort, we identified a novel <i>NRG1</i> gene fusion, a <i>RET</i> fusion, 2 <i>EGFR</i>, and 3 <i>KRAS</i> mutations, as well as mutations in <i>IDH1, RIT1, NOTCH</i>, and <i>NF1</i> In addition, we identified CNV in multiple proto-oncogenes genes including <i>PDGFRA, KIT, KDR, GNAS, K/HRAS, RET, NTRK1, MAP2K1,</i> and others.<b>Conclusions:</b> We identified a putative TKI resistance mechanism in six of 12 (50%) ROS1 <i><sup>+</sup></i> patients and 37 of 43 (86%) ALK<sup>+</sup> patients. Our data suggest that a focus on KDMs will miss most resistance mechanisms; broader gene testing strategies and functional validation is warranted to devise new therapeutic strategies for drug resistance. <i>Clin Cancer Res; 24(14); 3334-47. ©2018 AACR</i>.
Point-cloud-to-point-cloud technique on tool calibration for dental implant surgical path tracking (2008)

Dental implant is one of the most popular methods of tooth root replacement used in prosthetic dentistry. Computerize navigation system on a pre-surgical plan is offered to minimize potential risk of damage to critical anatomic structures of patients. Dental tool tip calibrating is basically an important procedure of intraoperative surgery to determine the relation between the hand-piece tool tip and hand-piece's markers. With the transferring coordinates from preoperative CT data to reality, this parameter is a part of components in typical registration problem. It is a part of navigation system which will be developed for further integration. A high accuracy is required, and this relation is arranged by point-cloud-to-point-cloud rigid transformations and singular value decomposition (SVD) for minimizing rigid registration errors. In earlier studies, commercial surgical navigation systems from, such as, BrainLAB and Materialize, have flexibility problem on tool tip calibration. Their systems either require a special tool tip calibration device or are unable to change the different tool. The proposed procedure is to use the pointing device or hand-piece to touch on the pivot and the transformation matrix. This matrix is calculated every time when it moves to the new position while the tool tip stays at the same point. The experiment acquired on the information of tracking device, image acquisition and image processing algorithms. The key success is that point-to-point-cloud requires only 3 post images of tool to be able to converge to the minimum errors 0.77%, and the obtained result is correct in using the tool holder to track the path simulation line displayed in graphic animation.
Contribution of noradrenergic inputs to hypoglossal motoneuron (IHMN) activity in decerebrate dogs (2011)

Radocaj, T.; Mustapic, S.; Stuth, E. A.E.; Stucke, A. G.; Zuperku, E. J. Author Information
Continuous HFSI techniques applied to rotor position estimation of IPMSM at standstill and low speed &#x2014; A survey (2011)

Sensorless techniques have got considerable importance in IPMSM drives researches. In the two past decades, a number of High Frequency Signal Injection (HFSI) techniques have been proposed and developed for IPMSM rotor position estimation at standstill and low speed. These techniques are divided into transient signal injection techniques, which are based on exploiting the PWM signal to extract the rotor position, and continuous signal injection techniques, which are based on stationary frame injection or synchronous frame injection. This paper gives an overview of continuous approaches relative to sensorless position estimation using HFSI techniques. A comparison between their rotor position extraction schemes is established to conclude to advantages and disadvantages of each scheme.
Panoramic-reconstruction temporal imaging for seamless measurements of slowly-evolved femtosecond pulse dynamics (2017)

Single-shot real-time characterization of optical waveforms with sub-picosecond resolution is essential for investigating various ultrafast optical dynamics. However, the finite temporal recording length of current techniques hinders comprehensive understanding of many intriguing ultrafast optical phenomena that evolve over a timescale much longer than their fine temporal details. Inspired by the space-time duality and by stitching of multiple microscopic images to achieve a larger field of view in the spatial domain, here a panoramic-reconstruction temporal imaging (PARTI) system is devised to scale up the temporal recording length without sacrificing the resolution. As a proof-of-concept demonstration, the PARTI system is applied to study the dynamic waveforms of slowly evolved dissipative Kerr solitons in an ultrahigh-Q microresonator. Two 1.5-ns-long comprehensive evolution portraits are reconstructed with 740 fs resolution and dissipative Kerr soliton transition dynamics, in which a multiplet soliton state evolves into a stable singlet soliton state, are depicted.Real-time characterization of ultrafast dynamics comes with a tradeoff between temporal resolution and recording length. Here, Li et al. use a temporal reconstruction technique inspired by panoramic microscopy to image the dynamics of slowly evolved dissipative Kerr solitons in a microresonator.
Non-linear Galilean vestibular receptive fields (2011)

We present a set of formulas for the receptive fields of the vestibular neurons that are motivated by Galilean invariance. We show that these formulas explain non-trivial data in neurophysiology, and suggest new hypothesis to be tested in dynamical 3D conditions. Moreover our model offers a way for neuronal computing with 3D displacements, which is reputed to be hard, underlying the vestibular reflexes. This computation is presented in a Bayesian framework. The basis of the model is the necessity of living bodies to work invariantly in space-time, allied to the necessary discreteness of neuronal transmission.
Reference Architecture and Classification of Technologies, Products and Services for Big Data Systems (2015)

Many business cases exploiting big data have been realised in recent years; Twitter, LinkedIn, and Facebook are examples of companies in the social networking domain. Other big data use cases have focused on capturing of value from streaming of movies (Netflix), monitoring of network traffic, or improvement of processes in the manufacturing industry. Also, implementation architectures of the use cases have been published. However, conceptual work integrating the approaches into one coherent reference architecture has been limited. The contribution of this paper is technology independent reference architecture for big data systems, which is based on analysis of published implementation architectures of big data use cases. An additional contribution is classification of related implementation technologies and products/services, which is based on analysis of the published use cases and survey of related work. The reference architecture and associated classification are aimed for facilitating architecture design and selection of technologies or commercial solutions, when constructing big data systems.
A Terrestrial Solar Power Plant with Direct Energy Conversion (1992)

&lt;div class="htmlview paragraph"&gt;In the 70-80 s a number of conceptions of solar power plants with thermoelectric and thermionic converters of thermal energy in electric one was offered. The investigations performed in some countries in the field of direct conversion closely brought these conceptions to practical realization. At present developments of components of solar power plants: thermionic converters (TEC) and thermoelectric generators (TEG), thermal and electric energy accumulatory,optical concentrators allow to create a plant with efficiency ∼ 20% and more for terrestrial and space usage.&lt;/div&gt;
Immune Status of SJL/J Mice in Relation to Age and Spontaneous Tumor Development2 (1973)

The immunologic status, occurrence of autoantibodies, and serum abnormalities in relation to age increase and pathologic changes were investigated in SJL/J mice. The Immunologic reactivity of normal SJL/J mice and those with spontaneous reticulum-cell tumors was evaluated with age increase. Tested were the response to sheep red blood cells, prolongation of skin allograft survival, delayed hypersensitivity skin reaction, and graft-versus-host reaction. The immune reactivity decreased as the mice grew older, whether the host was normal or tumor bearing. This defective immunologic status early in life did not seem, therefore, to be a factor in the spontaneous tumor development. Antibodies to nuclear material were detectable in normal animals as early as 3 months and increased with age in normal animals, but were significantly less common in tumor-bearing animals. Direct antiglobulin tests (Coombs') on blood samples taken from animals ranging from 6 to 14 months of age were negative. Serial serum electrophoresis showed the presence of proteins, sometimes myeloma-like, with restricted heterogeneity, always associated with mainly early tumors in 6- to 10-month-old mice, and an abundance of plasma cells.
Experimental evidence for partial spatial coherence in imaging Mueller polarimetry (2017)

We demonstrate experimentally the validity of the partial spatial coherence formalism in Mueller polarimetry and show that, in a finite spatial resolution experiment, the measured response is obtained through convolving the theoretical one with the instrument function. The reported results are of primary importance for Mueller imaging systems.
Evidence of vancomycin resistance gene transfer between enterococci of human origin in the gut of mice harbouring human microbiota (2005)

Here, we show for the first time that transfer of the vanA gene cluster can occur between Enterococcus strains in the DT colonized with a human microbiota and in the absence of selective pressure. The colonization properties of other enterococci transconjugants and the influence of vancomycin intake should be further investigated since transfers in the DT of animals and humans might contribute to emergence and dissemination of new vancomycin-resistant bacteria.
The Natural Combination Medicine Traumeel (Tr14) Improves Resolution of Inflammation by Promoting the Biosynthesis of Specialized Pro-Resolving Mediators (2021)

The resolution of inflammation is an integral part of the acute inflammatory response and eventually leads to the return to homeostasis. It is supported by specialized pro-resolving mediators (SPMs) that act as immunoresolvents via specific G-protein-coupled receptors. In contrast to classical non-steroidal anti-inflammatory drugs (NSAIDs) that suppress the formation of pro-inflammatory lipid mediators such as prostaglandins, novel pharmacotherapeutic concepts propose to foster the biosynthesis of beneficial SPMs. Here, we demonstrate that the natural combination medicine Traumeel (Tr14) improves resolution of inflammation by promoting SPM formation. Tr14 enhanced the biosynthesis of 12-/15-lipoxygenase (LOX) products and of SPMs in zymosan-induced mouse peritonitis as well as in human monocyte-derived macrophages challenged with <i>Staphylococcus aureus</i>. Importantly, in the peritonitis model, Tr14 supported the recruitment of innate leukocytes and the efferocytotic capacity of macrophages, and positively influenced the inflammation resolution index. Taken together, we suggest that based on these properties Tr14 may possess therapeutic potential as an enhancer for the resolution of inflammatory processes.
DAVE: a plug-and-play model for distributed multimedia application development (1995)

We created the Distributed Audio Video Environment for developing applications. DAVE is unique in that it provides a distributed plug-and-play application programming interface, is object-oriented, offers device and media extensibility, uses traditional Unix network facilities for transmission, and employs existing audio and video hardware commonly found on many workstations. To demonstrate DAVE's usefulness, we used it to develop two multimedia applications applicable to collaborative engineering: desktop videoconferencing and video broadcasting/receiving. DAVE's object-oriented techniques provide a high level of abstraction for devices. Application developers can treat media devices (such as cameras and microphones) as distributed resources, much as workstations treat graphics and windows. This flexibility and accessibility lets developers easily integrate multimedia into existing distributed environments. Through inheritance and data independence, developers can define additional devices and media types and integrate them into the environment. This plug-and-play approach provides easy access for application developers who want to avoid learning the details of media devices or who want to dynamically change their applications at runtime.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A robust self-tuning PID-type control for time-varying process in the pharmaceutical industry (2022)

In this work, we present a comparison between three PID-type controllers designed via different methods for a process with time-varying properties. Such a process is commonly encountered in the process industry, with prevalence in the chemical, food and pharmaceutical manufacturing industries. The controllers are varying in complexity from operator level (rule-based) to expert tuning (computer-aided design) and beyond state of art (generalized fractional-order control). Experimental tests indicate the feasibility of the controllers for variations in time constant with varying operation conditions originating from physical changes in the process. This is rather a common problem in practice and highly relevant for control engineering. Furthermore, an analysis of the system properties reveals the opportunity to operate in closed loop in a self-tuning manner, which avoids the necessity to re-design the controller parameter values.
An Analysis of Finite-Memory Random Linear Coding on Packet Streams (2006)

We consider the following packet coding scheme: The coding node has a fixed, finite memory in which it stores packets formed from an incoming packet stream, and it sends packets formed from random linear combinations of its memory contents. We analyze the scheme in two settings: as a self-contained component in a network providing reliability on a single link, and as a component employed at intermediate nodes in a block-coded end-to-end connection. We believe that the scheme is a good alternative to automatic repeat request when feedback is too slow, too unreliable, or too difficult to implement.
Early Mortality After Diagnosis of Multiple Myeloma: Analysis of Patients Entered Onto the United Kingdom Medical Research Council Trials Between 1980 and 2002—Medical Research Council Adult Leukaemia Working Party (2005)

A tenth of patients die within 60 days of diagnosis of MM. Infection and renal failure are the main direct causes of early mortality, which cannot be accurately predicted by presenting prognostic features. All patients should be considered at high risk of death during induction therapy.
Structure-activity relationships of pyrrole amidine antiviral antibiotics. 2. Preparation of mono- and tripyrrole derivatives of congocidine (1980)

Representatives of three types of congocidine (1) analogues were synthesized. These were tested for cytotoxicity, inhibition of herpes simplex virus (HSV) replication in cultured cells, and effects on the synthesis of HS DNA in isolated nuclei in vitro, as well as on DNA synthesis by purified HSV DNA polymerase. All synthesized tripyrrole derivatives of congocidine were less cytotoxic and more active than the parent drug in all the three ant iviral tests.
Optimizing Parallel Collaborative Filtering Approaches for Improving Recommendation Systems Performance (2019)

Recommender systems are one of the fields of information filtering systems that have attracted great research interest during the past several decades and have been utilized in a large variety of applications, from commercial e-shops to social networks and product review sites. Since the applicability of these applications is constantly increasing, the size of the graphs that represent their users and support their functionality increases too. Over the last several years, different approaches have been proposed to deal with the problem of scalability of recommender systems’ algorithms, especially of the group of Collaborative Filtering (CF) algorithms. This article studies the problem of CF algorithms’ parallelization under the prism of graph sparsity, and proposes solutions that may improve the prediction performance of parallel implementations without strongly affecting their time efficiency. We evaluated the proposed approach on a bipartite product-rating network using an implementation on Apache Spark.
SOP Elektrokonvulsionstherapie (2017)

Die Elektrokonvulsionstherapie (EKT) stellt bis heute ein wichtiges Therapieverfahren zur Behandlung verschiedener psychiatrischer Erkrankungen dar. Insbesondere bei der Behandlung von schweren und therapieresistenten Depressionen ist die EKT mit Remissionsraten von 60 – 80 % unverzichtbar 1 2.
Increased Plasma Adenosine Concentration in the Subacute Phase May Contribute to Attenuation of Left Ventricular Dilation in the Chronic Phase in Patients With Acute Myocardial Infarction (2019)

The plasma adenosine concentration significantly increased 14 days after AMI, which may contribute to attenuation of LV dilation in the chronic phase.
Lansoprazole-Based Colorimetric Chemosensor for Efficient Binding and Sensing of Carbonate Ion: Spectroscopy and DFT Studies (2021)

The new benzimidazole based receptor <b>Lansoprazole</b> has been used to detect carbonate anion by naked-eye and Uv-Vis spectroscopy. This receptor revealed visual changes with <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msubsup><mml:mrow><mml:mtext>CO</mml:mtext></mml:mrow> <mml:mrow><mml:mn>3</mml:mn></mml:mrow> <mml:mrow><mml:mn>2</mml:mn> <mml:mo>-</mml:mo></mml:mrow> </mml:msubsup> </mml:math> anion in ethanol. No detectable color changes were observed upon the addition of any other tested anions. The lansoprazole chemosensor selectively recognizes <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msubsup><mml:mrow><mml:mtext>CO</mml:mtext></mml:mrow> <mml:mrow><mml:mn>3</mml:mn></mml:mrow> <mml:mrow><mml:mn>2</mml:mn> <mml:mo>-</mml:mo></mml:mrow> </mml:msubsup> </mml:math> ion over the other interference anions in the ethanol, followed by deprotonation and reflected 1:1 complex formation between the receptor and the carbonate ion. Lansoprazole exhibits splendid selectivity toward carbonate ion via a visible color change from colorless to yellow with a detection limit of 57 μM. The binding mode of <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msubsup><mml:mrow><mml:mtext>CO</mml:mtext></mml:mrow> <mml:mrow><mml:mn>3</mml:mn></mml:mrow> <mml:mrow><mml:mn>2</mml:mn> <mml:mo>-</mml:mo></mml:mrow> </mml:msubsup> </mml:math> to receptor <b>L</b> is supported by Density Functional Theory calculation. Moreover, this receptor shows a practical visible colorimetric test strip for the detection of carbonate ions. The transition states calculation demonstrates the occurrence of reaction from <b>L</b> to <b>L</b>- <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msubsup><mml:mrow><mml:mtext>CO</mml:mtext></mml:mrow> <mml:mrow><mml:mn>3</mml:mn></mml:mrow> <mml:mrow><mml:mn>2</mml:mn> <mml:mo>-</mml:mo></mml:mrow> </mml:msubsup> </mml:math> after overcoming an energy barrier of 10.1 kcal/mol, and there is considerable interaction energy between <b>L</b> and <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msubsup><mml:mrow><mml:mtext>CO</mml:mtext></mml:mrow> <mml:mrow><mml:mn>3</mml:mn></mml:mrow> <mml:mrow><mml:mn>2</mml:mn> <mml:mo>-</mml:mo></mml:mrow> </mml:msubsup> </mml:math> (94.9 kJ/mol), both of which confirmed that receptor <b>L</b> has high sensitivity and selectivity to the carbonate ion. The theoretical studies were performed to acquire an electronic description of the complexation mechanism by <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msubsup><mml:mrow><mml:mtext>CO</mml:mtext></mml:mrow> <mml:mrow><mml:mn>3</mml:mn></mml:mrow> <mml:mrow><mml:mn>2</mml:mn> <mml:mo>-</mml:mo></mml:mrow> </mml:msubsup> </mml:math> as well as to study bonding and structure in the complex. The optimized structures and binding mechanisms were supported with a high correlation and agreement by spectroscopy and DFT calculations.
A site‐specific insertion sequence in flax genotrophs induced by environment (2005)

A single-copy 5.7 kilobase (kb) DNA fragment, termed Linum Insertion Sequence 1 (LIS-1), has been identified and characterized. This is one of the DNA changes associated with the environmentally induced heritable changes resulting in stable lines termed genotrophs in flax (Linum usitatissimum). The insertion sequence and its insertion site have been cloned from genomic libraries and sequenced. PCR products across the insertion and surrounding regions have also been cloned and sequenced. The 5.7 kb DNA fragment is inserted into a 3.7 kb EcoRI fragment in the plastic line (Pl) with the generation of a 3 base pair duplication at the insertion site, as well as additional sequence changes. The identical insertion was also found in other genotrophs and flax varieties. The intact element was not present in Pl but appeared to be generated by a reproducible series of complex rearrangements or insertion events. LIS-1 is the result of a targeted, highly specific, complex insertion event that occurs during the formation of some of the genotrophs, and occurs naturally in many flax and linseed varieties.