gebhart/patrepeval huggingface dataset:
Sequences encoding C2H2 zinc fingers inhibit polyadenylation and mRNA export in human cells (2018)

The large C2H2-Zinc Finger (C2H2-ZNF) gene family has rapidly expanded in primates through gene duplication. There is consequently considerable sequence homology between family members at both the nucleotide and amino acid level, allowing for coordinated regulation and shared functions. Here we show that multiple C2H2-ZNF mRNAs experience differential polyadenylation resulting in populations with short and long poly(A) tails. Furthermore, a significant proportion of C2H2-ZNF mRNAs are retained in the nucleus. Intriguingly, both short poly(A) tails and nuclear retention can be specified by the repeated elements that encode zinc finger motifs. These Zinc finger Coding Regions (ZCRs) appear to restrict polyadenylation of nascent RNAs and at the same time impede their export. However, the polyadenylation process is not necessary for nuclear retention of ZNF mRNAs. We propose that inefficient polyadenylation and export may allow C2H2-ZNF mRNAs to moonlight as non-coding RNAs or to be stored for later use.
PyI11: Pyroelectric properties of thin film lead scandium tantalate (1992)

Abstract Electrical measurements on thin film ferroelectric lead scandium tantalate, deposited from solution, are described. It has good pyroelectric properties, approaching those of the bulk ceramic material. Its potential for thermal imaging applications is discussed. A theoretical specific detectivity of 4 × 108cmHz1/2W−1 has been calculated using measured film properties in a simple detector array structure.
Flexible unipolar thermoelectric devices based on patterned poly[Kx(Ni-ethylenetetrathiolate)] thin films (2017)

A unipolar thermoelectric device of poly[K<sub>x</sub>(Ni-ethylenetetrathiolate)] was patterned <italic>via</italic> an electrochemical process on a prepatterned PET substrate with printed PDMS.
A Series of Iron(II)‐NHC Sensitizers with Remarkable Power Conversion Efficiency in Photoelectrochemical Cells** (2021)

A series of six new Fe(II)NHC-carboxylic sensitizers with their ancillary ligand decorated with functions of varied electronic properties have been designed with the aim to increase the metal-to- surface charge separation and light harvesting in iron-based dye-sensitized solar cells (DSSCs). ARM130 scored the highest efficiency ever reported for an iron-sensitized solar cell (1.83 %) using Mg<sup>2+</sup> and NBu<sub>4</sub> I-based electrolyte and a thick 20 μm TiO<sub>2</sub> anode. Computational modelling, transient absorption spectroscopy and electrochemical impedance spectroscopy (EIS) revealed that the electronic properties induced by the dimethoxyphenyl-substituted NHC ligand of ARM130 led to the best combination of electron injection yield and spectral sensitivity breadth.
Ab initiomolecular dynamics for open-shell transition metals (1993)

We show that quantum-mechanical molecular-dynamics simulations in a finite-temperature local-density approximation based on the calculation of the electronic ground state and of the Hellmann-Feynman forces after each time step are feasible for liquid noble and transition metals. This is possible with the use of Vanderbilt-type ``ultrasoft'' pseudopotentials and efficient conjugate-gradient techniques for the determination of the electronic ground state. Results for liquid copper and vanadium are presented.
Abstract 12908: Alpha-1 Anti-trypsin Inhibits the Acute Inflammatory Response in Patients With ST-Segment Elevation Myocardial Infarction (2014)

Introduction: Alpha-1 anti-trypsin (AAT) is an anti-inflammatory protein abundant in the plasma. Studies in mice have shown anti-inflammatory and cardioprotective properties of plasma derived AAT in experimental myocardial infarction (MI). Hypothesis: Plasma derived AAT (Prolastin C) inhibits the acute inflammatory response in patients with ST-segment elevation myocardial infarction (STEMI). Methods: Ten patients with acute STEMI were enrolled in an open-label single-arm treatment study of Prolastin C at 60 mg/kg intravenously within 12 hours of admission. High-sensitivity C reactive protein (CRP) and plasma AAT levels were determined at admission, 72 hours and 14 days, and followed clinically for up to 12 weeks for the occurrence of new onset heart failure (HF), recurrent MI or death. Twenty patients with STEMI enrolled in 2 prior clinical trials with identical inclusion criteria, and were randomly assigned to placebo served as historical controls. Data is presented as median and interquartile range, and...
Location based Authentication Service using 4G/5G Devices (2019)

Mobile devices 4G/5G have become an important part of our day to day lives. Accessing internet applications has become much easier due to mobile phones. Mobile phones nowadays have been built with new technologies like location based services like GPS. Mobile phones which make it easy to access applications and are the gateway to authentication failure can be used to provide authentication and protect user's private and confidential information. As mobiles have become important for our existence its important have them secured and have them authenticated. Location-based technique is one of the new technologies used to check authentication through smart phones. Authentication is one of the building blocks of security measures and mobile phones can compromise it. For example, if a phone is lost anyone can hack into the phone and get all the confidential information like bank account details and can use the credit card or debit card details. To avoid such scenarios location-based authentication services can be used to collect data and analyze the user's movements and actions. As using internet applications through Smartphones 4G/5G devices has become such a rage, it is necessary to have few methods to help authenticate users. I intend to survey and give out all the methods which use location services to authenticate users and help in maintaining the security. In this paper, I would like to summarize the methods.
On the Convexity of Feasible QoS Regions (2007)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> The feasible quality-of-service (QoS) region is the set of all QoS vectors that can be provided to the users by means of power control, with interference treated as noise. In an interference-limited scenario, this set is determined by the Perron root of some QoS-dependent nonnegative matrix. In a previous work, we showed that if the signal-to-interference ratio (SIR) is a log-convex function of the QoS, then the Perron root is a log-convex function. This implies convexity of the feasible QoS region. In this correspondence, we prove that the log-convexity property is also necessary for the Perron root to be convex for any choice of the (path) gain matrix. Interestingly, a significantly less restrictive property is sufficient when the gain matrix is confined to be symmetric positive semidefinite. </para>
Real time detection and compensation of registration errors in a network of radars (2001)

This paper describes an algorithm designed to automatically compensate for the angular and positional misalignment of the members of a network of radars using nothing more than the operational data. The method is based upon the simple observation that within any given observation period a significant number of the target aircraft will take flight paths along lines of constant bearing. By using such sets of straight line motion, observed commonly by a pair of radars, it is possible to arrive at an estimate of the relative azimuthal bias between the two. By conducting this estimation for each radar in the network with reference to one nominated member, all the relative azimuthal offsets can then be computed. Once the rotational biases have been resolved it is then feasible to calculate any x, y offset in the actual position of the radars relative to their published coordinates using the same data.
RE-ARCHITECTING AND RE-ENGINEERING TRADING AND TREASURY SYSTEMS IN THE MERGER OF CHEMICAL BANK AND MANUFACTURERS HANOVER TRUST -- An Interview with Brian Slater, Vice-President, Chemical Bank (1993)

This chapter presents an edited transcript of an interview held in August 1993 with Brian Slater, a vice-president in the Global Bank at Chemical Bank. Slater is responsible for the firm's U.S.-based trading and global risk management systems. The interview was conducted in the context of Project 1990s -- the U.S. Council for International Banking's Study on Information Technology Investment and International Banking Performance. The purpose of the discussion was to develop background information on the issues the bank's senior management team faced in merging the trading and treasury functions of Chemical Bank and Manufacturers Hanover Trust. The new Global Bank faces challenges in the areas of global risk management, cost-effective delivery of in formation technology-based products, trading infrastructure application functionality gaps, and human resource management that can be best addressed by a shift to a new paradigm for trading and treasury application software development: reuse of object-oriented representations of the bank's systems. We now turn to the details of the discussion that develops these themes.
Pharmacokinetics and metabolism of a selective PDE5 inhibitor (UK-343,664) in rat and dog (2001)

1. UK-343,664 is a novel potent and selective PDE5 inhibitor. Plasma clearances in the male and female rat were high (120 and 54 ml min(-1) kg(-1)), giving rise to short elimination half-lives (0.2 and 0.3h respectively). Lower clearance in dog (14 ml min(-1) kg(-1)) was the primary factor resulting in a longer elimination half-life (3.7 h). The higher clearance in rat than dog was in agreement with in vitro metabolism rates in hepatic microsomes. 2. The volume of distribution was lower in rat (1.3-2.11 kg(-1)) compared with dog (4.61 kg(-1)) probably due to increased plasma protein binding in rat (96 versus 81% in dog). 3. Oral bioavailabilities were 2, 12 and 70% in the male and female rat and dog respectively. Tmax < or = 0.5 h in all animals. 4. In multiple oral dose studies, increased systemic exposure was seen with increasing dose up to doses of 200 mg kg(-1) in rat and 150 mg kg(-1) in dog. A marked super-proportional increase in the male rat indicated a capacity-limited clearance at high doses. 5. At the maximal dose of 200 mg kg(-1) in the female rat, no clinical signs were observed after 14 days of treatment. Only minimal signs were recorded in the male rat and dog at the highest dose levels investigated. 6. After single oral or intravenous doses of [14C]-UK-343,664, the majority of radioactivity was excreted in the faeces of both species. 7. UK-343,664 was extensively metabolized in both rat and dog. The major primary pathways in dog involved piperazine N-deethylation and loss of a two carbon fragment from the piperazine ring (N,N'-de-ethylation). More extensive metabolism in the rat included additional notable metalbolites arising from hydroxylation and lactamization of the piperazine ring, which were only minor metabolites in the dog.
Controllable Optical and Electrical Properties of Nb Doped TiO<inf>2</inf> Films by RF Sputtering (2018)

RF magnetron sputtered Nb doped titanium oxide (TiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> :Nb) thin film on alkali-free glass substrate is shown to provide good transparency and low resistivity. Both the optical and electrical properties are closely dependent on the deposition parameters as well as the post-annealing process. The impact of deposition power (100-400 W), deposition temperature (25-200 °C) and O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> /O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> +Ar flow rate ratio (0-9.09%) on the optical and electrical properties have been studied. A significant improvement of the conductivity of TiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> : Nb thin film is observed after annealing at 600 °C over 60min, leading to the decrease of resistivity from 7×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> Ω·cm to 2×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> Ω·cm and the transparency over 70% in the visible wavelength. Due to its high work function and the obtained good opto-electrical property, TiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> :Nb has a great potential as an electron selective contact for dopant-free Si solar cells or transparent conductive oxide material.
Carbonic Anhydrase Inhibitors Induce Elevations in Human Whole-Blood Zinc Levels (1984)

The use of carbonic anhydrase inhibitors (CAIs) was associated with mean increases in whole-blood zinc levels of 82 micrograms/dL and 70 micrograms/dL, respectively, in a cross-sectional survey and in a prospective study of patients with glaucoma. The time course of the increase suggests that CAIs induce reticulocyte synthesis of carbonic anhydrase.
Pediatric and adult global hypoxic-ischemic injury evaluated by diffusion-weighted imaging and MR spectroscopy (2006)

K. A. Tong, A. Dengel, C. Carr, U. Oyoyo, S. Ashwal, S. Uffindell, B. A. Holshouser Radiology, Loma Linda University Medical Center, Loma Linda, California, United States, School of Medicine, Loma Linda University Medical Center, Loma Linda, California, United States, Epidemiology and Biostatistics, Loma Linda University Medical Center, Loma Linda, California, United States, Pediatrics, Loma Linda University Medical Center, Loma Linda, California, United States, Neurology, Loma Linda University Medical Center, Loma Linda, California, United States Introduction: Diffusion weighted imaging (DWI) has been established as an important tool in the diagnosis of acute infarction, but has been less studied in the setting of global hypoxic-ischemic injury. Studies have been performed on animal models of hypoxia, as well as neonatal/perinatal asphyxia. However, there are only a few small DWI studies of hypoxic injury in the non-neonatal population with only recent evaluation of objective ADC measures . There are even fewer studies that combine DWI and MRS evaluation in this setting. The purpose of this study was to evaluate the ability of DWI to assess brain injury after hypoxic injury, in a larger sample of patients. Specifically, apparent diffusion coefficient (ADC) values were measured in pre-selected brain regions to determine if there was a correlation with patient outcomes. Comparison with MR spectroscopy data was also performed.
Keyframe-based visual-inertial online SLAM with relocalization (2017)

Complementing images with inertial measurements has become one of the most popular approaches to achieve highly accurate and robust real-time camera pose tracking. In this paper, we present a keyframe-based approach to visual-inertial simultaneous localization and mapping (SLAM) for monocular and stereo cameras. Our visual-inertial SLAM system is based on a real-time capable visual-inertial odometry method that provides locally consistent trajectory and map estimates. We achieve global consistency in the estimate through online loop-closing and non-linear optimization. Furthermore, our system supports relocalization in a map that has been previously obtained and allows for continued SLAM operation. We evaluate our approach in terms of accuracy, relocalization capability and run-time efficiency on public indoor benchmark datasets and on newly recorded outdoor sequences. We demonstrate state-of-the-art performance of our system compared to a visual-inertial odometry method and baseline visual SLAM approaches in recovering the trajectory of the camera.
Effects of growth hormone and ovariectomy on performance, serum hormones, insulin-like growth factor-binding proteins, and muscle fiber properties of prepubertal Friesian heifers. (1995)

Sixteen prepubertal Friesian heifers were used to examine the effect of bovine growth hormone (GH) and ovariectomy (OVX) at 2.5 mo of age (2 x 2 factorial design) on growth, carcass quality, and fiber types, capillarization, and metabolic potentials of the longissimus muscle, and serum concentrations of estradiol-17beta (E2beta), insulin, GH, IGF-I, and IGF-binding proteins (IGFBP). Treatment with GH (15 mg/d) started at 147 +/- 3 kg BW and lasted for 15 wk. Heifers were fed a mixed roughage-based diet. Growth hormone increased ADG (P < .001), improved gain:feed (P < .007), and had a small but positive influence on lean accretion. Growth hormone reduced fat thickness (P < .009), carcass fat trim (P < .009) and i.m. fat (P < .09). Ovariectomy did not affect performance but increased dressing percentage (P < .03), full rib weight (P < .003), and fat thickness (P < .04). Ovariectomy reduced E2beta (P < .001) and insulin (P < .02), and increased the 32-kDa IGFBP (IGFBP-2) (P < .09). Growth hormone treatment increased GH, IGF-I, the 28-kDa IGFBP, and the 40- to 43-kDa IGFBP (IGFBP-3) (P < .004 or P < .001). Neither GH nor ovariectomy affected the proportion and relative area of the individual muscle fiber types, but GH tended to increase type I fiber area (P < .10). Number of capillaries per fiber increased in OVX GH-treated heifers (GH x OVX interaction, P < .02). Activities of citrate synthetase were higher in GH-treated (P < .05) and OVX (P < .02) heifers, indicating increased oxidative capacity of the longissimus muscle. The effects of GH on performance and carcass fattening were in accordance with the observed hormonal changes. When slaughter occurs before puberty, ovariectomy has no effect on performance, only few effects on carcass quality, and small effects on hormone concentrations.
Selection of Wolf Dens in Relation to Winter Territories in Northeastern Minnesota (1992)

Locations of wolf (Canus lupus) dens in the Superior National Forest in northeastern Minnesota from 1969 through 1988 were analyzed in relation to winter territories. Dens situated within the central 60% of the territories were randomly located relative to territory centers. However, only 10.5% (2) of the dens were located within a 1-km-wide strip inside the territory boundaries, indicating possible avoidance of neighboring packs. A negative relationship (r2 = 0.27; P < 0.05) between territory size and den distance from territory center was found, indicating that in large territories wolves might select the denning site that minimizes travel distance from and to the den. Den use was traditional in 86% (6) of the denning alpha females studied for >1 year, and possibly the availability of a stable food source helped determine den location.
How to do air quality testing in the equine barn. (2006)

The way that we house and exercise our horses, especially in non-temperate climates such as New England, is well entrenched in the equine culture. It may conserve space to store hay overhead, it may be economically favorable and more comfortable to have the indoor arena attached to the main barn, and it may make us more comfortable to close up our barns in the winter, but this management style results in high organic dust and endotoxin exposure for our horses. This dust exposure results in exacerbation of signs in horses with recurrent airway obstruction (RAO) and is also strongly associated with inflammatory airway diseases (IADs). Organic dust exposure has been shown to result in long-term declines in respiratory function and increased prevalence of chronic lung diseases in humans—it is logical to expect that the same exposures will have similar effects on equine respiratory health. We believe that it is important to decrease this exposure to both horses and people in equine barns, and changing this exposure flies in the face of long-established equine culture. Hard numbers can make it easier for owners and trainers to accept hard facts, and it is possible for veterinarians to generate these hard numbers with air quality evaluation. Our ultimate aim is to improve the respiratory health and well being of all horses exposed to organic dust and, eventually, to develop strategies for decreasing organic dust exposure in equine management. Authors’ address: Tufts University, Cummings School of Veterinary Medicine, 200 Westboro Road, North Grafton, MA 01536; e-mail: melissa.mazan@tufts.edu (Mazan). © 2006 AAEP.
Surface curvature and basal hydraulic stress induce spatial bias in cell extrusion (2023)

Abstract Epithelial cell extrusion is employed in maintaining a healthy epithelium. It remains unclear how environmental conditions specific to various epithelial tissues, such as geometry and fluid osmolarity, affect cell extrusions. We found that, over curved surfaces, epithelial monolayers exhibited higher extrusion rates in concave regions than convex ones. This difference, and overall extrusions, decreased when osmotically induced basal hydraulic stress was reduced by increasing media osmolarity or by culturing monolayers on hydrogels. Mechanistically, basal fluid accumulation antagonized cell-substrate adhesions and the subsequent FAK-Akt survival pathway, leading to apoptotic cell death. Convex surfaces induced cellular forces that acted against osmosis, thereby promoting adhesions and lowering apoptosis. This effect was reversed in concave regions, and together, resulted in the curvature induced spatial bias in cell extrusions.
Fabrication of a vanadium nitride/N-doped carbon hollow nanosphere composite as an efficient electrode material for asymmetric supercapacitors (2020)

Low-cost materials and facile processes to obtain novel electrode materials for assembling asymmetric supercapacitors (ASCs) are urgently needed. Herein, a vanadium nitride/nitrogen-doped carbon nanosphere (VN/NCS) composite composed of VN nanoparticles and N-doped carbon (NC) covering the surface of VN has been prepared by the nitridation of a V<sub>2</sub>O<sub>3</sub>/C nanocomposite. The hollow VN/NCS composite with a mesoporous structure and the dispersion of VN NPs in N-doped carbon result in a VN/NCS composite with good electrochemical behavior. Moreover, the N-doped carbon layer on the surface of VN effectively inhibits the oxidation of VN during cycling in an alkaline electrolyte. With the VN/NC composite utilized as a novel active electrode material for SCs, good rate capability, specific capacitance, and cycling stability are exhibited. Strikingly, using the VN/NCS composite as a negative electrode and its precursor, the V<sub>2</sub>O<sub>3</sub>/C composite, as a positive electrode, an asymmetric supercapacitor (ASC) device, with a good energy density of 19.8 W h kg<sup>-1</sup> at 801 W kg<sup>-1</sup> and a short charging time of 89 s, was assembled.
Injection-locking unstable resonator excimer lasers (1983)

We review the basic criteria for effective and efficient injection locking of high-power excimer lasers, and enumerate the various parameters of practical concern for experimental implementation. Various injection schemes are compared and the fundamental limitations of the process are covered. Corroborative experimental results are also reviewed, and applications made possible by injection locking are discussed.