gebhart/patrepeval huggingface dataset:
Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity (2020)

Chronic pain is highly variable between individuals, as is the response to analgesics. Although much of the variability in chronic pain and analgesic response is heritable, an understanding of the genetic determinants underlying this variability is rudimentary1. Here we show that variation within the coding sequence of the gene encoding the P2X7 receptor (P2X7R) affects chronic pain sensitivity in both mice and humans. P2X7Rs, which are members of the family of ionotropic ATP-gated receptors, have two distinct modes of function: they can function through their intrinsic cationic channel or by forming nonselective pores that are permeable to molecules with a mass of up to 900 Da2,3. Using genome-wide linkage analyses, we discovered an association between nerve-injury–induced pain behavior (mechanical allodynia) and the P451L mutation of the mouse P2rx7 gene, such that mice in which P2X7Rs have impaired pore formation as a result of this mutation showed less allodynia than mice with the pore-forming P2rx7 allele. Administration of a peptide corresponding to the P2X7R C-terminal domain, which blocked pore formation but not cation channel activity, selectively reduced nerve injury and inflammatory allodynia only in mice with the pore-forming P2rx7 allele. Moreover, in two independent human chronic pain cohorts, a cohort with pain after mastectomy and a cohort with osteoarthritis, we observed a genetic association between lower pain intensity and the hypofunctional His270 (rs7958311) allele of P2RX7. Our findings suggest that selectively targeting P2X7R pore formation may be a new strategy for individualizing the treatment of chronic pain.
6H-Pyrrolo[3,2-b:4,5-b′]bis[1,4]benzothiazines: facilely synthesized semiconductors for organic field-effect transistors (2008)

6H-Pyrrolo[3,2-b:4,5-b′]bis[1,4]benzothiazine (PBBTZ, 1) and its two 6-substituted derivatives (2 and 3) were conveniently synthesized. Their optical properties were studied by UV-vis and fluorescence spectroscopy, and electrochemical properties were investigated by cyclic voltammetry (CV). Good thermal stability was observed by thermogravimetric analysis. X-Ray analysis revealed a coplanar structure and a column stacking in the single crystal of compound 1. OFET measurements showed that 1–3 were p-type semiconductors. The performance of these devices displayed good reproducibility at ambient conditions. When devices containing 1 were fabricated on OTS-treated SiO2/Si substrates at 60 °C, the best performance was achieved with the average hole mobility as high as 0.34 cm2V−1 s−1 and the on/off ratio about 106–107. This performance resulted from the well-ordered molecular packing as revealed by XRD and AFM analysis.
Hydrogen Production: 3D Self‐Architectured Steam Electrode Enabled Efficient and Durable Hydrogen Production in a Proton‐Conducting Solid Oxide Electrolysis Cell at Temperatures Lower Than 600 °C (Adv. Sci. 11/2018) (2018)

In article number 1800360, Dong Ding and co-workers report a self-architectured ultraporous 3D electrode for steam electrolysis at intermediate temperatures. The proton-conducting electrolysis cell using this steam electrode demonstrates highly efficient and durable hydrogen production below 600 °C, which is attributed to improved mass transfer and increased active reaction area, as well as the electrode reconstruction under operation conditions.
Cost-Effective Optimization of Surveillance Cultures for MRSA in the Neonatal Intensive Care Unit at a University Hospital (2015)

メチシリン耐性黄色ブドウ球菌(MRSA)の監視培養は，高リスク病棟で実施されるが，検査頻度や検体種類は施設によって様々であり，過剰検査を避けるためにも費用対効果は十分検討されるべきである．当院では2005年から2010年までに細菌培養検査件数が1.5倍に増加し，特に糞便や鼻腔ぬぐい液など監視培養に用いられる検体数が急増していた．そこで，この傾向が顕著な新生児集中治療室(NICU)に着目し，監視培養の実態やMRSA検出状況を調査した．NICUでは，2008年にMRSA検出数が増加したために，全症例で毎週1回，鼻腔ぬぐい液と糞便の監視培養行われ，検体数増加の主因となっていた．後方視的にMRSA検出状況を調べると，糞便からMRSAが検出された患児は，鼻腔ぬぐい液からも同時に検出されており，しかも，いったん定着したMRSAは長期間検出され続けることが明らかとなった．これらの結果を踏まえ，2011年より監視培養は鼻腔ぬぐい液のみとし，MRSA定着後は監視培養を中止するなどの変更を行った．その結果，同科のMRSA検出率に変化はなかった．一方で，検体数が前年度比で32%減少し，監視培養に関わる費用は74%の削減となった．このように，疫学データをもとに監視培養方法を見直すことで，無駄のない効果的なMRSA監視が可能になると考えられた．
Regulation of biosynthesis, perception, and functions of strigolactones for promoting arbuscular mycorrhizal symbiosis and managing root parasitic weeds (2019)

Strigolactones (SLs) are carotenoid-derived plant secondary metabolites that play important roles in various aspects of plant growth and development as plant hormones, and in rhizosphere communications with symbiotic microbes and also root parasitic weeds. Therefore, sophisticated regulation of the biosynthesis, perception and functions of SLs is expected to promote symbiosis of beneficial microbes including arbuscular mycorrhizal (AM) fungi and also to retard parasitism by devastating root parasitic weeds. We have developed SL mimics with different skeletons, SL biosynthesis inhibitors acting at different biosynthetic steps, SL perception inhibitors that covalently bind to the SL receptor D14, and SL function inhibitors that bind to the serine residue at the catalytic site. In greenhouse pot tests, TIS108, an azole-type SL biosynthesis inhibitor effectively reduced numbers of attached root parasites Orobanche minor and Striga hermonthica without affecting their host plants; tomato and rice, respectively. AM colonization resulted in weak but distinctly enhanced plant resistance to pathogens. SL mimics can be used to promote AM symbiosis and to reduce the application rate of systemic-acquired resistance inducers which are generally phytotoxic to horticultural crops. © 2019 Society of Chemical Industry.
Analysis of the Interaction of Insulin-Like Growth Factor I (IGF-I) Analogs with the IGF-I Receptor and IGF-Binding Proteins (1994)

Analogs of insulin-like growth factor I (IGF-I) have been prepared by site-directed mutagenesis in order to determine the structural domains of IGF-I required for IGF receptor and IGF-binding protein (IGFBP) binding, and to produce analogs with selective affinity for receptors or IGFBP to determine the physiologic roles of these proteins. Distinct domains of IGF-I are important for maintaining high affinity for the IGF-I receptor and for the various species of IGFBPs. The analogs that selectively bind to the receptor and have reduced affinity for IGFBPs have proved useful in determining the relative importance of IGFBPs in the regulation of the biologic activity of IGF-I. In most cases, analogs with reduced affinity for IGFBP have increased or normal potency compared with IGF-I. These data suggest that binding of IGF-I to IGFBP inhibits its biologic activity. As these analogs are cleared more rapidly after parenteral administration, however, they do not provide a significant advantage over IGF-I for in vivo administration. Analogs with poor affinity for the receptor have also been useful in demonstrating that a given activity of IGF-I is mediated by the type 1 IGF receptor. These studies confirm that the role of these various proteins in IGF-I action is complex, and may be cell specific or tissue-type specific.
Concentric CT for single-well, steam-assisted gravity drainage (1996)

Having completed an extensive study into the design and fabrication of insulated concentric coiled tubing, several Single Well-Steam Assisted Gravity Drainage{sup PatPend} (SW-SAGD) installations have already been completed and are in production. This article reviews this process and documents production results from some of these early wells. Several innovative methods have been developed to enhance and extend productive life of heavy oil reserves in Canada. Many of these incorporate steam injection to help reduce viscosity and, therefore, improve in-situ flow characteristics of oil. Requiring extensive capital for development and operation, these projects are often limited by economic considerations.
Biodegradation of mixture of plastic films by tailored marine consortia (2019)

This work sheds light on the physicochemical changes of naturally weathered polymer surfaces along with changes of polymer buoyancy due to biofilm formation and degradation processes. To support the degradation hypothesis, a microcosm experiment was conducted where a mixture of naturally weathered plastic pieces was incubated with an indigenous pelagic community. A series of analyses were employed in order to describe the alteration of the physicochemical characteristics of the polymer (FTIR, SEC and GPC, sinking velocity) as well as the biofilm community (NGS). At the end of phase II, the fraction of double bonds in the surface of microbially treated PE films increased while changes were also observed in the profile of the PS films. The molecular weight of PE pieces increased with incubation time reaching the molecular weight of the virgin pieces (230,000 g mol<sup>-1</sup>) at month 5 but the buoyancy displayed no difference throughout the experimental period. The number-average molecular weight of PS pieces decreased (33% and 27% in INDG and BIOG treatment respectively), implying chain scission; accelerated (by more than 30%) sinking velocities compared to the initial weathered pieces were also measured for PS films with biofilm on their surface. The orders Rhodobacterales, Oceanospirillales and Burkholderiales dominated the distinct platisphere communities and the genera Bacillus and Pseudonocardia discriminate these assemblages from the planktonic counterpart. The functional analysis predicts overrepresentation of adhesive cells carrying xenobiotic and hydrocarbon degradation genes. Taking these into account, we can suggest that tailored marine consortia have the ability to thrive in the presence of mixtures of plastics and participate in their degradation.
Scanning Electron Microscopy of Wet Biological Specimens (2003)

Journal Article Scanning Electron Microscopy of Wet Biological Specimens Get access Opher Gileadi, Opher Gileadi QuantomiX, Ltd. P.O.Box 4037, Nes Ziona 70400, Israel opher@quantomix.com Search for other works by this author on: Oxford Academic Google Scholar Vered Behar, Vered Behar QuantomiX, Ltd. P.O.Box 4037, Nes Ziona 70400, Israel opher@quantomix.com Search for other works by this author on: Oxford Academic Google Scholar Sini Ezer, Sini Ezer QuantomiX, Ltd. P.O.Box 4037, Nes Ziona 70400, Israel opher@quantomix.com Search for other works by this author on: Oxford Academic Google Scholar Miri Horowitz, Miri Horowitz QuantomiX, Ltd. P.O.Box 4037, Nes Ziona 70400, Israel opher@quantomix.com Search for other works by this author on: Oxford Academic Google Scholar Amotz Nechushtan, Amotz Nechushtan QuantomiX, Ltd. P.O.Box 4037, Nes Ziona 70400, Israel opher@quantomix.com Search for other works by this author on: Oxford Academic Google Scholar Alon Sabban, Alon Sabban QuantomiX, Ltd. P.O.Box 4037, Nes Ziona 70400, Israel opher@quantomix.com Search for other works by this author on: Oxford Academic Google Scholar David Sprinzak, David Sprinzak QuantomiX, Ltd. P.O.Box 4037, Nes Ziona 70400, Israel opher@quantomix.com Search for other works by this author on: Oxford Academic Google Scholar Anya Vainshtein, Anya Vainshtein QuantomiX, Ltd. P.O.Box 4037, Nes Ziona 70400, Israel opher@quantomix.com Search for other works by this author on: Oxford Academic Google Scholar Ory Zik Ory Zik QuantomiX, Ltd. P.O.Box 4037, Nes Ziona 70400, Israel opher@quantomix.com Search for other works by this author on: Oxford Academic Google Scholar Microscopy and Microanalysis, Volume 9, Issue S03, 1 September 2003, Pages 486–487, https://doi.org/10.1017/S1431927603039059 Published: 04 September 2003
High-Intensity Interval Training for Adults With Chronic Stroke: A Pilot Feasibility Study (2020)

Purpose: This study was conducted to assess the feasibility of twice weekly treadmill high-intensity interval training (HIIT) after stroke; to measure cardiorespiratory (CR) changes and assess predictors of CR change and the validity of existing age-predicted maximal heart rate (AP-HR max ) equations to dose HIIT; and to determine the effect of HIIT on functional measures. Methods: Seventeen adults ≥6 months poststroke participated in twice-weekly, supervised HIIT plus 30-minute home walking sessions for 10 weeks (n = 10) or served as control participants (CON, n = 7). Feasibility was measured by HIIT attendance (≥90%) and attaining targeted HIIT parameters with no adverse events. Cardiorespiratory response, peak HR, and function were measured before and after intervention. Validity of AP-HR max equations was assessed. Results: Feasibility was supported (99% of training sessions completed, no adverse events, and targeted intensity achieved). V̇ o 2peak increased significantly for HIIT, P = .019 and decreased for CON, P = .044. Functional outcomes did not improve for either group. Age-predicted maximal heart rate equations were valid, with poor absolute agreement at baseline and post-test for HIIT ( P = .024; P = .003) and CON ( P = .012; P = .005). Conclusions: Ten weeks of twice-weekly HIIT is feasible post-stroke and increased aerobic capacity, but functional outcomes did not improve. Some existing AP-HR max equations can be used to formulate HIIT exercise prescription.
Computer-aided dosage in oral anticoagulation therapy using phenprocoumon (2010)

Oral anticoagulation using vitamin K antagonists has been established for over 50 years. Although it is highly effective in preventing thromboembolic incidents, its therapeutic control still remains problematic. Therefore, a computer-aided approach is recommended for deriving dosages. Up to now, the dosage is often based on the visual inspection of previous INR measurements, average weekly doses, and the INR target range. Statistical variations of measurement results and time-delayed effects of dosages, however, frequently result in the misinterpretation of data and suggest pseudo-trends. Treating physicians are not only responsible for determining the patient-specific maintenance dose, but must also respond to deviating INR values, overdosage or underdosage, initiate the oral anticoagulation therapy, and control the INR level in case of a new target range (bridging). Instructive examples are provided to illustrate the described difficulties. A computer-aided expert system is currently developed to ensure the therapeutic safety under the specified conditions. We present preliminary results from a study designed to validate mathematical models underlying such expert systems.
Elevated serum magnesium lowers calcification propensity in Memo1-deficient mice (2020)

MEdiator of cell MOtility1 (MEMO1) is a ubiquitously expressed redox protein involved in extracellular ligand-induced cell signaling. We previously reported that inducible whole-body Memo1 KO (cKO) mice displayed a syndrome of premature aging and disturbed mineral metabolism partially recapitulating the phenotype observed in Klotho or Fgf23-deficient mouse models. Here, we aimed at delineating the contribution of systemic mineral load on the Memo1 cKO mouse phenotype. We attempted to rescue the Memo1 cKO phenotype by depleting phosphate or vitamin D from the diet, but did not observe any effect on survival. However, we noticed that, by contrast to Klotho or Fgf23-deficient mouse models, Memo1 cKO mice did not present any soft-tissue calcifications and displayed even a decreased serum calcification propensity. We identified higher serum magnesium levels as the main cause of protection against calcifications. Expression of genes encoding intestinal and renal magnesium channels and the regulator epidermal growth factor were increased in Memo1 cKO. In order to check whether magnesium reabsorption in the kidney alone was driving the higher magnesemia, we generated a kidney-specific Memo1 KO (kKO) mouse model. Memo1 kKO mice also displayed higher magnesemia and increased renal magnesium channel gene expression. Collectively, these data identify MEMO1 as a novel regulator of magnesium homeostasis and systemic calcification propensity, by regulating expression of the main magnesium channels.
Residual and absolute timing jitter in actively mode-locked semiconductor lasers (1990)

The magnitude and origin of the pulse-to-pulse timing jitter that is added to the modulating source by an actively modelocked laser is discussed. Residual and absolute RMS timing jitter measurements as low as 50 fs and 170fs, respectively, have been measured in optimally tuned cavities.
Would Magnonic Circuits Outperform CMOS Counterparts? (2022)

In the early stages of a novel technology development, it is difficult to provide a comprehensive assessment of its potential capabilities and impact. Nevertheless, some preliminary estimates can be drawn and are certainly of great interest and in this paper we follow this line of reasoning within the framework of the Spin Wave (SW) computing paradigm. In particular, we are interested in assessing the technological development horizon that needs to be reached in order to unleash the full SW paradigm potential such that SW circuits can outperform CMOS counterparts in terms of energy consumption. In view of the zero power SWs propagation through ferromagnetic waveguides, the overall SW circuit power consumption is determined by the one associated to SWs generation and sensing by means of transducers. While current antenna based transducers are clearly power hungry recent developments indicate that magneto-electric (ME) cells have a great potential for ultra-low power SW generation and sensing. Given that MEs have been only proposed at the conceptual level and no actual experimental demonstration has been reported we cannot evaluate the impact of their utilization on the SW circuit energy consumption. However, we can perform a reverse engineering alike analysis to determine ME delay and power consumption upper bounds that can place SW circuits in the leading position. To this end, we utilize a 32-bit Brent-Kung Adder (BKA) as discussion vehicle and compute the maximum ME delay and power consumption that could potentially enable a SW implementation able to outperform its 7nm CMOS counterpart. We evaluate different BKA SW implementations that rely on conversion or normalization gate cascading and consider continuous or pulsed SW generation scenarios. 31nW is the maximum transducer power consumption for which a 32-bit BKA SW implementation can outperform its 7nm CMOS counterpart.
Autonomic Coordination of IoT Device Management Platforms (2020)

With the adoption of the Internet of Things (IoT), devices become integrated in our daily lives. These devices are more and more interdependent, either by guaranteeing connectivity, or by providing data for complex services. In an ever-evolving IoT context, continuously managing these connected objects is crucial, to handle vulnerabilities, ensure their well-functioning, and add new services. These features fall under the scope of Device Management (DM). The distribution and scalability of DM platforms become all the more exacerbated as device profiles and deployment use cases get more heterogeneous. Thus, multiple actors are involved in IoT services, with their respective, isolated, DM platforms. However, DM operations, such as reboots and firmware updates, have a direct impact on the state of devices, which requires awareness across DM platforms. In this paper, we address conflicts linked to connectivity dependencies, which may arise during the simultaneous execution of DM operations on interdependent devices. Hence, we propose a coordinator that collects DM operation intentions from isolated DM platforms and detects the relevant dependencies, so as to plan and orchestrate the execution of these operations. An evaluation of this middleware is presented, with perspectives for industrial applications.
Myeloid leukemia switch as immune escape from CD19 chimeric antigen receptor (CAR) therapy (2016)

Gardner et al. recently reported on two cases of mixed lineage leukemia (MLL) + acute myeloid leukemia (AML) occurring after CD19 chimeric antigen receptor (CAR) therapy for MLL + B-acute lymphoblastic leukemia (ALL) (1). This report provides new insights into mechanisms of immune escape from targeted immunotherapy and strategies to prevent their occurrence with adapted immune interventions.
An Investigation of Presence Response across Variations in Visual Realism (2004)

This paper describes reports on the results of an experiment designed to study the impact of realism on the reported presence in an immersive virtual environment. An experiment was carried out with 40 participants who were asked to walk through a virtual street, which had virtual characters walking through it. Two factors were varied – texture quality (2 levels) and virtual character realism (2 levels). 10 participants were assigned to each cell, which was also balanced for gender. The results suggest that the lowest presence was achieved with the higher fidelity characters but the less varied textures. Other factors such as perceived realism of character behaviour were important. Finally a system called PIAVCA for virtual character control is introduced which was used in conjunction with DIVE [25, 29]. Keywords--Virtual Environment, Textures, Virtual Characters, Visual Realism, Presence.
Optimization of Device Clocking Schemes to Minimize the Effects of Radiation Damage in Charge-Coupled Devices (2012)

The European Space Agency Euclid mission aims to answer the question of how the universe originated through the mapping of the dark Universe. One method to investigate this geometry is to measure subtle changes in ellipticity using image sensors such as the charge-coupled device (CCD). However, the radiation environment in space plays a major part in the performance of CCD-based camera systems. When placed in space, a CCD becomes damaged by the radiation environment, and this can lead to a “smearing” of the charge, acting to change the ellipticity, and therefore, one must be able to separate the changes in ellipticity caused by radiation damage from those the mission aims to measure. To this end, the radiation-damage-induced shape changes require an in-depth investigation such that optimized operation can be achieved. A Monte Carlo simulation is being used to predict this impact, backed by experimental data from a detector formerly baselined for the mission. During the experimental study, an investigation was undertaken into the serial readout of the CCD to demonstrate an approach toward performance optimization through a consideration of the trap species involved. A change in the clocking scheme was found to result in a factor of 3 reduction in charge transfer inefficiency.
Annealing impact on damascene Cu resistivity and microstructures (2002)

The effect of different post electroplating anneals on dual damascene Cu microstructures and via chain yields using both rapid thermal processing and furnace anneal were investigated. It was found the grain size, [111] texture and Cu line resistance varied strongly with the annealing conditions. The minimum feature of trench width or height imposes physical limit to the average grain size. The Cu line resistivity increases rapidly as the feature size becomes smaller than 0.2 /spl mu/m. Electron scattering from both sidewalls and grain boundaries played significant roles even at geometries several times of the electron mean free path in Cu.