gebhart/patrepeval huggingface dataset:
Pre-clinical studies in cough research: Role of Transient Receptor Potential (TRP) channels (2013)

Cough is a protective reflex and defence mechanism in healthy individuals, which helps clear excessive secretions and foreign material from the lungs. Cough often presents as the first and most persistent symptom of many respiratory diseases and some non-respiratory disorders, but can also be idiopathic, and is a common respiratory complaint for which medical attention is sought. Chronic cough of various aetiologies is a regular presentation to specialist respiratory clinics, and is reported as a troublesome symptom by a significant proportion of the population. Despite this, the treatment options for cough are limited. The lack of effective anti-tussives likely stems from our incomplete understanding of how the tussive reflex is mediated. However, research over the last decade has begun to shed some light on the mechanisms which provoke cough, and may ultimately provide us with better anti-tussive therapies. This review will focus on the in vitro and in vivo models that are currently used to further our understanding of the sensory innervation of the respiratory tract, and how these nerves are involved in controlling the cough response. Central to this are the Transient Receptor Potential (TRP) ion channels, a family of polymodal receptors that can be activated by such diverse stimuli as chemicals, temperature, osmotic stress, and mechanical perturbation. These ion channels are thought to be molecular pain integrators and targets for novel analgesic agents for the treatment of various pain disorders but some are also being developed as anti-tussives.
Analog smart antennas: an overview (2003)

Analog approaches are expected to offer dramatically low power consumption in smart antennas, especially for battery-operated wireless terminal devices. This paper overviews recently developed analog antenna techniques for smart beamforming. Hardware architectures, trained- and blind-control criteria, and adaptation algorithms are introduced along with state-of-the-art devices and a practical experiment.
Transcatheter valve in valve implantation for failed mitral and tricuspid bioprosthesis (2011)

The results of T-VIV procedure in the mitral position have been suboptimal, and four of the sixteen patients reported to date died. However, all patients were extremely diseased, and some of the reported failures were related to amendable technical factors relative to the surgical access or to the valve deployment technique. With increasing experience, this procedure might become indicated as an alternative to conventional surgery in selected patients, encouraging increased use of bioprosthesis, and marking a pivotal change in the management of valvular disease.
MIMO-OFDM spatial multiplexing technique implementation for GNU radio (2014)

Multiple-Input Multiple-Output (MIMO) is a wireless technology allowing a significant increasing of the throughput without the extension of the bandwidth but by means of the use of multiple antennas both in transmission and reception. Currently, Orthogonal Frequency Division Multiplexing (OFDM) is used in conjuction with MIMO to achieve better performance. With OFDM, instead of a single carrier, the main signal is split in a sub-set of independently modulated signals on orthogonal sub-carriers.
Editorial: Induced resistance and priming against pests and pathogens (2022)

Due to the rapidly changing climate and increasingly restrictive regulations on the use of pesticides, there is an urgent need to discover and develop new and more sustainable strategies of crop protection that meet the present and future needs of a growing world population. Fundamental research on plant-microbe and plant-insect interactions – both pathogenic and beneficial – is of key importance to gain a better molecular, physiological and ecological understanding of these complex interactions and so generate the tools necessary to develop new crop protection strategies.&#13;\n&#13;\nInduced resistance (IR) develops after treatment of plants with pathogens, pests, beneficial microorganisms, chemical agents, physical wounding, or herbivory. Plants exposed to such stimuli increase their level of basal resistance against future attacks compared to non-stimulated plants. IR is often based on a priming of basal defense mechanisms, which enables a faster and/or stronger defense response upon secondary challenge. Given its long-lasting nature and broad-spectrum effectiveness, IR has long been recognized for its value in integrated pest and disease management approaches. This Research Topic highlights the latest advances in research on IR and priming presented at the IOBC-PR-IR2022 conference in Sheffield, UK, from 4th to 7th April 2022, which is organized by the working group of the International Organization for Biological Control. In addition to reviewing the scientific significance of this work, we discuss future challenges in IR research and the potential application of IR in future crop protection strategies.
Verification of the capability of repeat-pass SAR interferometry to provide tree height information in boreal forest zone (2002)

A rather new aspect in SAR interferometry is the derivation of interferometric tree height over forested areas. This paper studied the impact of tree height and canopy closure on INSAR-derived terrain height in boreal forests. Previous studies in the field have suffered from the lack of good ground truth information, especially from the lack of canopy closure information, and, therefore, laser scanning measurements were used to generate DEM of the area, tree height and crown closure maps with a high accuracy (spatial resolution 0.5 m). The results imply that the impact of tree height was negligible on INSAR-derived DEM under winter conditions, and the capability of winter images to produce stem volume maps by the means of INSAR-derived tree height is probably impossible or, at least, limited. However, when pixels of equal characteristics were averaged instead of the near-by pixels, the effect of tree height and crown closure on the INSAR-derived DEM could be modelled and were found statistically significant.
Photolysis of bis[p-(1,1,3,3-tetramethylbutyl)phenyl]terephthalate (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotolysis of bis[p-(1,1,3,3-tetramethylbutyl)phenyl]terephthalateGerald R. Lappin and J. S. ZannucciCite this: J. Org. Chem. 1970, 35, 11, 3679–3682Publication Date (Print):November 1, 1970Publication History Published online1 May 2002Published inissue 1 November 1970https://doi.org/10.1021/jo00836a019RIGHTS & PERMISSIONSArticle Views48Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (519 KB) Get e-Alerts Get e-Alerts
Modification of PSf/SPSf Blended Porous Support for Improving the Reverse Osmosis Performance of Aromatic Polyamide Thin Film Composite Membranes (2018)

In this study, modification of polysulfone (PSf)/sulfonated polysulfone (SPSf) blended porous ultrafiltration (UF) support membranes was proposed to improve the reverse osmosis (RO) performance of aromatic polyamide thin film composite (TFC) membranes. The synergistic effects of solvent, polymer concentration, and SPSf doping content in the casting solution were investigated systematically on the properties of both porous supports and RO membranes. SEM and AFM were combined to characterize the physical properties of the membranes, including surface pore natures (porosity, mean pore radius), surface morphology, and section structure. A contact angle meter was used to analyze the membrane surface hydrophilicity. Permeate experiments were carried out to evaluate the separation performances of the membranes. The results showed that the PSf/SPSf blended porous support modified with 6 wt % SPSf in the presence of DMF and 14 wt % PSf had higher porosity, bigger pore diameter, and a rougher and more hydrophilic surface, which was more beneficial for fabrication of a polyamide TFC membrane with favorable reverse osmosis performance. This modified PSf/SPSf support endowed the RO membrane with a more hydrophilic surface, higher water flux (about 1.2 times), as well as a slight increase in salt rejection than the nascent PSf support. In a word, this work provides a new facile method to improve the separation performance of polyamide TFC RO membranes via the modification of conventional PSf porous support with SPSf.
MASS-FIX for the detection of monoclonal proteins and light chain N-glycosylation in routine clinical practice: a cross-sectional study of 6315 patients (2021)

Immunoenrichment-based matrix assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS), termed MASS-FIX, offers several advantages over immunofixation for the detection and isotyping of serum monoclonal protein, including superior sensitivity and specificity, the ability to differentiate therapeutic monoclonal antibodies, and the rapid identification of light chain (LC) N-glycosylation. We identified 6315 patients with MASS-FIX performed at our institution since 2018. Of these, 4118 patients (65%) with a wide array of plasma cell disorders (PCD), including rare monoclonal gammopathies of clinical significance, had a positive MASS-FIX. Two-hundred twenty-one (5%) of the MASS-FIX positive patients had evidence of LC N-glycosylation, which was more commonly identified in IgM heavy chain isotype, kappa LC isotype, and in diagnoses of immunoglobulin light chain (AL) amyloidosis and cold agglutinin disease (CAD) compared to other PCD. This cross-sectional study describes the largest cohort of patients to undergo MASS-FIX in routine clinical practice. Our findings demonstrate the widespread utility of this assay, and confirm that LC N-glycosylation should prompt suspicion for AL amyloidosis and CAD in the appropriate clinical context.
The relationship between health-related quality of life, obesity and testosterone levels in older men (2013)

www.clinicaltrials.gov, NCT00155961.
Bis(m-phenylene)-32-crown-10-Based Cryptands, Powerful Hosts for Paraquat Derivatives (2005)

Four new bis(m-phenylene)-32-crown-10-based cryptands with different third bridges were prepared. Their complexes with paraquat derivatives were studied by proton NMR spectroscopy, mass spectrometry, and X-ray analysis. It was found that these cryptands bind paraquat derivatives very strongly. Specifically, a diester cryptand with a pyridyl nitrogen atom located at a site occupied by either water or a PF(6) anion in analogous complexes exhibited the highest association constant K(a) = 5.0 x 10(6) M(-1) in acetone with paraquat, 9000 times greater than the crown ether system. X-ray structures of this and analogous complexes demonstrate that improved complexation with this host is a consequence of preorganization, adequate ring size for occupation by the guest, and the proper location of the pyridyl N-atom for binding to the beta-pyridinium hydrogens of the paraquat guests. This readily accessible cryptand is one of the most powerful hosts reported for paraquats.
cAMP Response Element-Binding Protein Regulates Differentiation and Survival of Newborn Neurons in the Olfactory Bulb (2005)

The transcription factor cAMP response element-binding protein (CREB) is involved in multiple aspects of neuronal development and plasticity. Here, we demonstrate that CREB regulates specific phases of adult neurogenesis in the subventricular zone/olfactory bulb (SVZ/OB) system. Combining immunohistochemistry with bromodeoxyuridine treatments, cell tracer injections, cell transplants, and quantitative analyses, we show that although CREB is expressed by the SVZ neuroblasts throughout the neurogenic process, its phosphorylation is transient and parallels neuronal differentiation, increasing during the late phase of tangential migration and decreasing after dendrite elongation and spine formation. In vitro, inhibition of CREB function impairs morphological differentiation of SVZ-derived neuroblasts. Transgenic mice lacking CREB, in a null CREM genetic background, show reduced survival of newborn neurons in the OB. This finding is further supported by peripheral afferent denervation experiments resulting in downregulation of CREB phosphorylation in neuroblasts, the survival of which appears heavily impaired. Together, these findings provide evidence that CREB regulates differentiation and survival of newborn neurons in the OB.
Necroptosis: a regulated inflammatory mode of cell death (2018)

Programmed cell death has a vital role in embryonic development and tissue homeostasis. Necroptosis is an alternative mode of regulated cell death mimicking features of apoptosis and necrosis. Necroptosis requires protein RIPK3 (previously well recognized as regulator of inflammation, cell survival, and disease) and its substrate MLKL, the crucial players of this pathway. Necroptosis is induced by toll-like receptor, death receptor, interferon, and some other mediators. Shreds of evidence based on a mouse model reveals that deregulation of necroptosis has been found to be associated with pathological conditions like cancer, neurodegenerative diseases, and inflammatory diseases. In this timeline article, we are discussing the molecular mechanisms of necroptosis and its relevance to diseases.
Development of the Midwest Guardrail System for Standard and Reduced Post Spacing and in Combination With Curbs: Part Two (2008)

Significant changes in the vehicle fleet over the past 10 years have led to changes in performance criteria for roadside safety hardware. In particular, replacement of the large sedan with a 3/4-ton pickup has caused reevaluation of much of the existing roadside safety hardware. One of the key questions in this reevaluation has been the performance of the W-beam guardrail. Several recent tests of W-beam guardrails have shown that successful capture and redirection of the 3/4-ton pickup vehicle is very sensitive to vehicle size, soil conditions, and post types. Unfortunately, these requirements do not appear to be satisfied by either standard W-beam rail systems nor the more costly 3-beam systems. In recognition of the potential for improving guardrail performance for high-center-of-gravity vehicles and the need to reestablish reasonable barrier height tolerances, the aims of this research project were to: examine the performance of W-beam guardrails and make necessary design changes; develop a guardrail-to-curb barrier combination that provides increased hydraulic capacity and placement farther in front of the rail face to reduce frequency of snow plow damage to guardrails; and 3) evaluate guardrail stiffening and determine appropriate guardrail placement guidelines for shielding rigid-hazards using full-, half-, and quarter-post spacing designs.
Towards Taming Privilege-Escalation Attacks on Android (2012)

Android’s security framework has been an appealing sub-ject of research in the last few years. Android has been shown to be vulnerable to application-level privilege esca-lation attacks, such as confused deputy attacks, and more recently, attacks by colluding applications. While most of the proposed approaches aim at solving confused deputy at-tacks, there is still no solution that simultaneously addresses collusion attacks. In this paper, we investigate the problem of designing and implementing a practical security framework for Android to protect against confused deputy and collusion attacks. We realize that defeating collusion attacks calls for a rather system-centric solution as opposed to application-dependent policy enforcement. To support our design decisions, we conduct a heuristic analysis of Android’s system behavior (with popular apps) to identify attack patterns, classify dif-ferent adversary models, and point out the challenges to be tackled. Then we propose a solution for a system-centric and policy-driven runtime monitoring of communication chan-nels between applications at multiple layers: 1) at the mid-dleware we control IPCs between applications and indirect communication via Android system components. Moreover, inspired by the approach in QUIRE, we establish semantic links between IPCs and enable the reference monitor to ver-ify the call-chain; 2) at the kernel level we realize mandatory access control on the file system (including Unix domain sockets) and local Internet sockets. To allow for runtime, dynamic low-level policy enforcement, we provide a callback channel between the kernel and the middleware. Finally, we evaluate the efficiency and effectiveness of our framework on known confused deputy and collusion attacks, and discuss future directions. 1.
Intergranular Corrosion in Al-Mg 5XXX Alloys under Atmospheric Exposures (2017)

Abstract Al-Mg 5XXX alloys are widely used for marine applications due to their low cost, high strength-to-weight ratio and good weldability. Alloys containing more than 3 wt% Mg, when exposed to standard service temperatures for extended periods of time, can become sensitized and susceptible to localized corrosion; particularly intergranular corrosion (IGC). Many studies have investigated this IGC phenomenon in AA5XXX and attribute it to precipitation of a more anodic β-phase (Al3Mg2) along grain boundaries after exposure to hot environments during service. Previous studies have investigated the role of metallurgical and electrochemical factors on IGC and indicate that degree of sensitization (DoS), orientation and time of exposure have a strong influence on grain boundary precipitation of β-phase and hence IGC in AA5XXX. The majority of IGC studies have been conducted in full immersion while much of the marine infrastructure is exposed to atmospheric conditions. There is a need to extend the full immersion corrosion framework and conduct IGC studies under atmospheric and/or thin film conditions. This study aims to develop a quantitative understanding of critical factors affecting IGC in AA5XXX under atmospheric exposures. The present work shows that cathodic kinetics play an important role in atmospheric or open circuit localized corrosion. Preliminary results have shown that strong oxidizers like ozone (O3) and persulfate (S2O −8), salt loading density, solution resistance, solution thickness, cathode area and type of cathode have a strong influence on IGC in thin films. A novel experimental set-up has also been developed to conduct electrochemical experiments in thin film electrolytes to explain the corrosion morphology observed in lab exposures. Initial thin film electrochemical results agree well with the existing corrosion framework for IGC in full immersion. An understanding of IGC in thin films/atmospheric exposures will provide a basis for developing a framework for IGC in thin films and comparing it to existing corrosion framework for IGC in full immersion.
Phase I Clinical Trial of Autologous Bone Marrow Mononuclear Cells for Pediatric Severe Traumatic Brain Injury (2009)

Cox, Charles S. M.D.; Baumgartner, James E. M.D.; Worth, Laura M.D., Ph.D.; Harting, Matthew T. M.D.; Ewing-Cobbs, Linda Ph.D.; Gee, Adrian Ph.D.; Hasan, Khader Ph.D.; Shah, Shinil; Walker, Peter M.D.; Day, Mary-Clare R.N.
Catalytic Asymmetric Synthesis of Mycolipenic and Mycolipanolic Acid (2009)

Abstract The first asymmetric synthesis of mycolipenic acid and mycolipanolic acid by using an improved iterative procedure involving catalytic asymmetric conjugate addition of MeMgBr as the key step is described. Mycolipenic and mycolipanolic acid are obtained in 11 steps with perfect stereocontrol, and both acids are identical to their counterparts from natural sources.
A graphene/zinc oxide nanocomposite film protects dental implant surfaces against cariogenicStreptococcus mutans (2014)

Oral biofilms play a crucial role in the development of dental caries and other periodontal diseases. Streptococcus mutans is one of the primary etiological agents in dental caries. Implant systems are regularly employed to replace missing teeth. Oral biofilms accumulate on these implants and are the chief cause of dental implant failure. In the present study, the potential of graphene/zinc oxide nanocomposite (GZNC) against the cariogenic properties of Streptococcus mutans was explored and the anti-biofilm behaviour of artificial acrylic teeth surfaces coated with GZNC was examined. Acrylic teeth are a good choice for implants as they are low cost, have low density and can resist fracture. Microscopic studies and anti-biofilm assays showed a significant reduction in biofilm in the presence GZNC. GZNC was also found to be nontoxic against HEK-293 (human embryonic kidney cell line). The results indicate the potential of GZNC as an effective coating agent for dental implants by efficiently inhibiting S. mutans biofilms.
Electronic and optical properties of magnesium and calcium hydroxides: the role of covalency and many-body effects (2015)

Magnesium and calcium hydroxides X(OH)2 (X = Mg, Ca) are multifunctional materials that have many important applications in industry, technology, and research. In solid-state electronics, the emerging applications of these compounds are related to photovoltaic devices. In the present paper we review electronic properties of X(OH)2, band gaps, work function, and features of chemical bonding and discuss theoretically predicted exciton effects.
Comparative Models of the File Assignment Problem (1982)

article Free Access Share on Comparative Models of the File Assignment Problem Authors: Lawrence W. Dowdy Department of Computer Science, Vanderbilt University, Nashville, Tennessee Department of Computer Science, Vanderbilt University, Nashville, TennesseeView Profile , Derrell V. Foster Department of Computer Science, Vanderbilt University, Nashville, Tennessee Department of Computer Science, Vanderbilt University, Nashville, TennesseeView Profile Authors Info & Claims ACM Computing SurveysVolume 14Issue 2June 1982 pp 287–313https://doi.org/10.1145/356876.356883Online:01 June 1982Publication History 391citation1,578DownloadsMetricsTotal Citations391Total Downloads1,578Last 12 Months45Last 6 weeks7 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Chyluria--experience of Taipei Veterans General Hospital. (2003)

Lymphangiography is the most powerful diagnostic tool. Intrarenal silver nitrate instillation is a safe and effective management of chyluria.