gebhart/patrepeval huggingface dataset:
Fine Structure and Morphogenesis of Borna Disease Virus (1999)

Borna disease virus (BDV), a negative nonsegmented single-stranded RNA virus, has not been fully characterized morphologically. Here we present what is to our knowledge the first data on the fine ultrastructure and morphogenesis of BDV. The supernatant of MDCK cells persistently infected with BDV treated with n-butyrate contained many virus-like particles and more BDV-specific RNA than that of untreated samples. The particles were spherical, enveloped, and approximately 130 nm in diameter; had spikes 7 nm in length; and reacted with BDV p40 antibody. A thin nucleocapsid, 4 nm in width, was present peripherally in contrast to the thick nucleocapsid of hemagglutinating virus of Japan. The BDV particles reproduced by budding on the cell surface.
Enhanced hybridization in the electronic ground state of the intercalated honeycomb iridate Ag3LiIr2O6 (2021)

In this work, we use x-ray spectroscopy at the Ir L<sub>3</sub>/L<sub>2</sub> absorption edge to study powder samples of the intercalated honeycomb magnet Ag<sub>3</sub>LiIr<sub>2</sub>O<sub>6</sub>. Based on x-ray absorption and resonant inelastic x-ray scattering measurements, and exact diagonalization calculations including nearest-neighbor Ir-Ir electron hopping integrals, we argue that the intercalation of Ag atoms results in a delocalized electronic structure with enhanced Ir-O hybridization, departing from the local relativistic j<sub>eff</sub>=1/2 state. We find that the relative orbital contribution to the magnetic moment is increased and the magnetization density is spatially extended and asymmetric in this hybridized state. Our results confirm the importance of metal-ligand hybridization in the magnetism of transition metal oxides and provide empirical guidance for understanding the collective magnetism in intercalated honeycomb iridates.
Environmentally Friendly Films Made With a New Family of Linear Ethylene Polymers (1994)

The public's ever-increasing environmental consciousness is driv ing the plastics packaging industry to constantly consider the complete life cy cle of their products. One avenue by which packaging film producers are responding to the "green" movement is by manufacturing polyolefin-based films containing Post-Consumer Recycled (PCR) polyolefins. These types of films are commercial in a wide variety of end uses, many of which have been tradition ally serviced by films made from high pressure process-low density polyethyl ene (HRLDPE). One obvious technical approach toward improving on this effort is to produce a film having as high a recycle content as possible but with a strength and toughness similar to that of the original HP-LDPE films. Any polymer which could effectively incorporate very high (50% +) levels of PCR into these type films would be of significant interest to the industry. Several new linear ethylene polymers have been used to increase the recycle content of these type films to very high levels while maintaining good film toughness properties. A series of blown films produced during an early screen ing study demonstrated the good physical properties and acceptable processing characteristics of these high PCR content blends containing these unique linear ethylene polymers.
Colloidal and Surfactant Properties of Poly (vinyl acetate-co- vinyl alcohol) copolymers (2013)

International audience
Development of high heat flux component for ITER divertor (2002)

The first fabrication and heating tests of a large-scale Carbon-Fiber-reinforced Composite (CFC) monoblock divertor mock-up using the annular flow concept were performed to demonstrate its manufacturability and thermo-mechanical performance. This mock-up was based on the design of the vertical target of the International Thermonuclear Experimental Reactor (ITER) divertor adapted for the annular flow concept. The annular cooling tube consists of two concentric tubes; the outer tube made of CuCrZr and the inner stainless steel tube with a twisted external fin. critical Heat Flux (CHF) testing of the annular cooling tube and brazed joint between the CFC and CuCrZr were performed prior to the fabrication of the mock-up to examine fabrication process. High heat flux test on this mock-up was performed in an ion beam facility. The mock-up has successfully withstood 1000 thermal cycles of 20MW/m^2,for 15s, which is relevant to the transient heat load of the ITER divertor. No degradation of the thermal performance of the mock-up has been observed throughout the thermal cycle test. These results show that the vertical target using the annular flow concept is applicable to the ITER divertor design.
Object-Oriented Model of BOM for Product Data Management (2002)

The object-oriented idea was used for the product structure and configuration management. SSPD(Single source of product data) was served for substrate data. BOM (Bill of materials) model was presented,which was applied to the management of dynamic product structure and design flow of the series packing machine.The composition of basic BOM and the configuration management concept of product BOM enabler were put forward,and the different configuration rules were established.According to the different configuration rules of product,the BOM structure is established,and the product structure configuration management of the series packing machine is achieved.
A 12.5+12.5 Gb/s Full-Duplex Plastic Waveguide Interconnect (2011)

A new interconnect solution with plastic waveguide is demonstrated. The system consists of a pair of transceivers and a plastic waveguide. Millimeter wave signal is transmitted in a low-cost long piece of solid plastic dielectric acting as a waveguide. The plastic waveguide medium offers a large bandwidth for data communication using mm-wave carrier frequencies. Plastic waveguide interconnects do not require costly electrical-to-optical and optical-to-electrical conversion devices or precise alignment and offer longer transmission distances than wireless solutions due to better field confinement and lower path loss. Multiple plastic waveguides can be used in parallel and the modulated data at different frequencies can be multiplexed to increase the data rate. The demonstrated transceiver chips operate at carrier frequencies of 57 GHz and 80 GHz, and are fabricated in 40 nm low-power logic CMOS. The total area and power consumption of two transceivers are 0.41 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and 140 mW, respectively. The fabricated demonstrator with Yagi-couplers achieves full-duplex transmission of 12.5 Gb/s ASK modulated signal in each direction over the 120 mm polystyrene waveguide with no equalization. The observed bit error rates for both channels are less than 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-12</sup> for a PRBS length of 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">7</sup> -1 at the total data rate of 25 Gb/s. This paper shows the feasibility of the plastic waveguide interconnect as a promising alternative to electrical, optical, and wireless interconnects.
Enantioselective imine hydrogenation with Ir diphosphine catalysts: fighting deactivation (2002)

While Ir diphosphine complexes are very active catalysts for the enantioselective hydrogenation of imines with good to excellent enantioselectivity, their deactivation is often a serious problem, leading to low catalyst productivity. Our study describes attempts to stabilize Ir catalysts with diop, bdpp and bppm ligands for the hydrogenation of different imines. The best results were obtained with complexes immobilised on silica gel and with bimetallic W–Ir and Mo–Ir complexes. In most cases, enantiomeric excesses as well as initial rates were only slightly affected while the stability of the catalysts was enhanced significantly.
Evaluation of Polymer Injection Projects in Brazil (2005)

Petrobras has implemented three polymer injection pilot projects during the last two decades, in the onshore fields of Canto do Amaro (Rio Grande do Norte state), Carmópolis (Sergipe state) and Buracica (Bahia state), all of them in Northeast of Brazil. The first one is in the middle of the operation and the last two are already finished.Polymer flood in oil reservoirs has been performed for several decades around the world. The polymers act basically increasing the viscosity of the injected water and reducing the porous media permeability, allowing for an increase in the vertical and areal sweep efficiency of the water injection, and, consequently, increasing the oil recovery.The main drive for the pilot projects in Petrobras was to gain practical knowledge of the process, for a possible future expansion for other reservoirs and even for offshore fields.This paper describes the experience of Petrobras in implementing and managing those polymer flood pilot projects. The laboratory tests, the designing and programming of the field operation, as well as the analysis and interpretation of the results, were all carried out by Petrobras personnel and are covered in this paper. The tracer injection for reservoir characterization purposes, which preceded the polymer floods, is also described.In this work we performed a technical evaluation of the whole polymer injection process, investigating the reservoir response in terms of oil recovery and time. The economical study will be made hereafter in another work.
Delivery of nanoparticles inside the cytosol of live cells for the monitoring of cellular processes (Conference Presentation) (2018)

The delivery of MOF-enzyme nanofactories (50-100 nm in diameter) into the cytosol of cells will be presented. Delivery is achieved by co-incubation with the peptide dfTAT, a dimeric construct of the HIV TAT peptide. Cytosolic targeting is highly efficient and dfTAT circumvents the endosomal entrapment of macromolecular cargos. The delivery protocol does not require interactions between dfTAT and nanoparticles, thereby eliminating complex labeling steps. Cytosolic access is rapid and cells recover from the delivery process in a matter of minutes. Overall, this approach should facilitate the monitoring of intracellular processes by nanoparticle probes.
Platelet function does not normalize after discontinuation of acetylsalicylic acid in cardiac patients (2009)

Aims: Discontinuation of chronic acetyl salicylic acid (ASA) medication 7 to 10 days prior cardiac surgery is considered to normalize platelet function. Consequently, ASA is withdrawn 7 days before surgery. However, diffuse bleeding is still observed. We retrospectively analyzed the efficacy of the current strategy.
A Comparison of Theory and Measurements in the Anode Region of a Self-Field Cylindrical MPD Thruster (1994)

Abstract : The need to validate and improve numerical models of the MPD thruster flow, using detailed comparisons with experimentally determined plasma properties, is essential in the effort to improve MPD thruster efficiency. This research represents an attempt to experimentally identify trends, in the variation of plasma properties inside of a self-field MPD thruster, which could be meaningfully compared with numerical results. Experimental results, consistent with the numerical model in trend, show an axial variation of the electron temperature along the anode which exhibits a very distinctive double-peaked profile. Experimental axial profiles of the electron number density and current density were also consistent with the numerical model in trend. Such evidence, along with results of the numerical model, suggest that an oblique shock is present near the inlet, and is required to establish the radial pressure gradient so prevalent in the MPD thruster. This work marks one of the first non-trivial, successful comparisons between a numerical model and experimentally determined plasma properties inside the MPD thruster.
Verification of Threshold Voltage Variation of Scaled Transistors with Ultralarge-Scale Device Matrix Array Test Element Group (2009)

Randomness of threshold voltage (VT) variations of negative channel field effect transistors (NFETs) and positive channel field effect transistors (PFETs) in the 65 nm technology is precisely examined. For this purpose, an ultralarge-scale device matrix array test element group (DMA-TEG) that contains 1 million single-size metal–oxide–semiconductor field-effect transistors (MOSFETs) has been designed and fabricated, and a very rapid measurement system has been developed. By evaluating VT of a very large number of MOSFETs, VT variation can be precisely evaluated. This rapid measurement is achieved by parallel address signal input, optimization of the measurement program, and 4-chip parallel measurements. The measured VT variations are decomposed into random and systematic components. The results reveal that the random component is overwhelmingly dominant in the VT variations in the 65 nm technology and that the VT variations exhibit a normal distribution up to ±5σ.
The zinc cluster transcription factor Czf1 regulates cell wall architecture and integrity in Candida albicans (2021)

The fungal cell wall is essential for the maintenance of cellular integrity and mediates interactions of the cells with the environment. It is a highly flexible organelle whose composition and organization is modulated in response to changing growth conditions. In the pathogenic yeast Candida albicans, a network of signaling pathways regulates the structure of the cell wall, and mutants with defects in these pathways are hypersensitive to cell wall stress. By harnessing a library of genetically activated forms of all C. albicans zinc cluster transcription factors, we found that a hyperactive Czf1 rescued the hypersensitivity to cell wall stress of different protein kinase deletion mutants. The hyperactive Czf1 induced the expression of many genes with cell wall-related functions and caused visible changes in the cell wall structure. C. albicans czf1Δ mutants were hypersensitive to the antifungal drug caspofungin, which inhibits cell wall biosynthesis. The changes in cell wall architecture caused by hyperactivity or absence of Czf1 resulted in an increased recognition of C. albicans by human neutrophils. Our results show that Czf1, which is known as a regulator of filamentous growth and white-opaque switching, controls the expression of cell wall genes and modulates the architecture of the cell wall.
Supplemental Figure 1 from A Role for Tryptophan-2,3-dioxygenase in CD8 T-cell Suppression and Evidence of Tryptophan Catabolism in Breast Cancer Patient Plasma (2023)

&lt;p&gt;LAT1 expression in breast cancer clinical samples.&lt;/p&gt;
Dissecting the contribution of Staphylococcus aureus α-phenol-soluble modulins to biofilm amyloid structure (2016)

The opportunistic pathogen Staphylococcus aureus is recognized as one of the most frequent causes of biofilm-associated infections. The recently discovered phenol soluble modulins (PSMs) are small α-helical amphipathic peptides that act as the main molecular effectors of staphylococcal biofilm maturation, promoting the formation of an extracellular fibril structure with amyloid-like properties. Here, we combine computational, biophysical and in cell analysis to address the specific contribution of individual PSMs to biofilm structure. We demonstrate that despite their highly similar sequence and structure, contrary to what it was previously thought, not all PSMs participate in amyloid fibril formation. A balance of hydrophobic/hydrophilic forces and helical propensity seems to define the aggregation propensity of PSMs and control their assembly and function. This knowledge would allow to target specifically the amyloid properties of these peptides. In this way, we show that Epigallocatechin-3-gallate (EGCG), the principal polyphenol in green tea, prevents the assembly of amyloidogenic PSMs and disentangles their preformed amyloid fibrils.
Dependence of Concanavalin A Binding on Anomeric Configuration, Linkage Type, and Ligand Multiplicity for Thiourea-Bridged Mannopyranosyl–β-Cyclodextrin Conjugates (2001)

No anomer discrimination: Concanavalin A (Con A) binds branched 6I-(α- and 6I-(β-D-mannopyranosylthioureido)cyclomaltoheptaoses with the same efficiency (see picture), in contrast with the known lectin specificity for the α anomer in the O-mannopyranosyl series. In addition, the presence of the cyclodextrin core slightly improves the binding efficiency. Unexpectedly, the heptakis(6-mannopyranosylthioureido)-β-cyclodextrins are not recognized. Reverse (6I→6)-linked thioureidomannosyl ligands are only weakly bound. These results underline the influence of the spatial organization of saccharide epitopes on the functional affinity of glycoclusters. Supporting information for this article (physical and spectroscopic data for compounds 5, 7, 9, 16, 17) is available on the WWW under http://www.chembiochem.com or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
LLL12, a novel small inhibitor targeting STAT3 for hepatocellular carcinoma therapy (2015)

The constitutive activation of signal transducer and activator of transcription 3 (STAT3) is frequently detected in clinical incidences of hepatocellular carcinoma (HCC) but not in normal human hepatocytes. STAT3 signaling plays pivotal roles in angiogenesis, survival, metastasis, and growth of HCC. Recent evidence suggests that the blockade of aberrant STAT3 pathways can be exploited as a therapeutic strategy for HCC. We have developed the novel small molecular STAT3 inhibitor LLL12 on the basis of curcumin structure using computer-aided rational design. LLL12 has shown antitumor activity in various solid tumors including breast, brain, pancreatic cancer, and glioblastoma in vitro and in vivo. In this study, we hypothesized LLL12 inhibits STAT3 phosphorylation at tyrosine 705 (Y705) in HCC and show antitumor activity in HCC in vitro and in vivo. Our results show that LLL12 selectively inhibited HCC cell proliferation and induced apoptosis in SNU387, SNU398, SNU449, and Hep3B HCC cells in vitro. Furthermore, LLL12 at 5 mg/kg/day significantly inhibited the growth of SNU398 xenografts in nude mice. Collectively, our results indicate that LLL12 could be used to target STAT3 for the effective prevention or treatment of HCC.
Peculiarities of femtosecond photon echo signals in dye-doped polymer films at high temperatures (2008)

Some results of femtosecond echo experiments on polyvinylbutyral polymer films doped with phtalocyanine molecules at high (up to room) temperatures are reported. Special attention is paid to the stimulated femtosecond photon echo (SFPE), which was observed in a solid-state medium at room temperature for the first time. A decay curve of the SFPE signal has been obtained and theoretically analyzed. The results of the analysis indicate that the random interaction between impurity molecules and quasi-localized low-frequency vibration modes in an amorphous matrix plays the dominant role in the character of optical dephasing at high temperatures.
Magnetoresistance Oscillations due to Charging Effects in Double Ferromagnetic Tunnel Junctions (1998)

Electron tunneling in a double junction consisting of two ferromagnetic electrodes, with a small ferromagnetic metallic grain in between, is analyzed theoretically in the Coulomb blockade regime. A new phenomenon, that of oscillations in tunneling magnetoresistance due to discrete charging effects, is predicted. The corresponding oscillation period depends on the charging energy, and the oscillations disappear when both junctions have the same spin asymmetry. The interplay of the oscillations and a nonoscillatory voltage dependence of the magnetoresistance is also analyzed.
Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology/Diagnosis/ Management (1998)

For the first time a CD-ROM of this classic text has been made available! - You can now access all the information from the text in a fully-searchable format, and much, much more ...Offers links to medline abstracts and papers, and a pathology atlas Features many new and improved illustrations ALL IN FULL COLOUR! Allows you to download all the images onto PowerPoint slides
Membrane staining for hepatitis B surface antigen on hepatocytes: a sensitive and specific marker of active viral replication in hepatitis B. (1995)

AIMS--To test the hypothesis that membranous staining of hepatitis B surface antigen (HBsAg) on the hepatocyte is a marker of active viral replication in chronic hepatitis B virus (HBV) infection. METHODS--Intrahepatic expression of HBsAg and hepatitis B core antigen (HBcAg) was studied by indirect immunofluorescence on frozen sections of liver specimens from 75 patients with chronic hepatitis B, and the results were correlated with serum levels of HBV-DNA assayed by spot hybridisation. RESULTS--Hepatocyte HBcAg was detected in all of 20 patients with serum levels of HBV-DNA > 1000 pg/ml, 18 (75%) of 24 patients with levels of HBV-DNA < or = 1000 pg/ml, and two (6.5%) of 31 patients without detectable serum HBV-DNA. The concordance between hepatocyte HBcAg and serum HBV-DNA was 89.3% (67/75). There were six patients (8%) who had detectable serum HBV-DNA but without hepatocyte HBcAg, and two patients (2.7%) who had detectable hepatocyte HBcAg but without serum HBV-DNA. Membranous staining of HBsAg associated with variable degrees of cytoplasmic HBsAg was found in all but one of 44 patients with serum HBV-DNA, irrespective of the levels, but in none of the 31 patients without serum HBV-DNA. Of the latter, HBsAg was distributed solely in the cytoplasm. In addition, there is an inverse correlation between serum levels of HBV-DNA and the degrees of cytoplasmic staining of HBsAg. The concordance between membranous staining fo HBsAg and serum HBV-DNA was 98.7% (74/75), significantly higher than that between hepatocyte HBcAG and serum HBV-DNA. CONCLUSIONS--Membranous staining of HBsAg on the hepatocyte correlated excellently with serum HBV-DNA and thus can be recognised as a sensitive and specific marker of active hepatitis B virus replication.
Joint Extraction of Entities and Relations Using Reinforcement Learning and Deep Learning (2017)

We use both reinforcement learning and deep learning to simultaneously extract entities and relations from unstructured texts. For reinforcement learning, we model the task as a two-step decision process. Deep learning is used to automatically capture the most important information from unstructured texts, which represent the state in the decision process. By designing the reward function per step, our proposed method can pass the information of entity extraction to relation extraction and obtain feedback in order to extract entities and relations simultaneously. Firstly, we use bidirectional LSTM to model the context information, which realizes preliminary entity extraction. On the basis of the extraction results, attention based method can represent the sentences that include target entity pair to generate the initial state in the decision process. Then we use Tree-LSTM to represent relation mentions to generate the transition state in the decision process. Finally, we employ <i>Q</i>-Learning algorithm to get control policy <i>π</i> in the two-step decision process. Experiments on ACE2005 demonstrate that our method attains better performance than the state-of-the-art method and gets a 2.4% increase in recall-score.
Prediction of Breast Cancer Risk Based on Profiling With Common Genetic Variants (2015)

The PRS stratifies breast cancer risk in women both with and without a family history of breast cancer. The observed level of risk discrimination could inform targeted screening and prevention strategies. Further discrimination may be achievable through combining the PRS with lifestyle/environmental factors, although these were not considered in this report.