gebhart/patrepeval huggingface dataset:
Medium-term alteration of rotifers assemblage in the flow-through system (Papuk Nature Park, NE Croatia) (2015)

Diverse but moderate macrophytes coverage supports species and habitat diversity, likewise maintain sustainable ecosystem heterogeneity which is particularly important in protected karst areas. Results of our previous study confirmed that inshore and macrophytes covered zone enable development of plankton community and in interaction with biotic relationships governed zooplankton assemblage in the flow-through system. Sustention or reestablishment of submerged macrophytes stands is overall accepted method in lake restoration. Contrary, overwhelming of macrophytes coverage indicating on ecosystem decay and requires improving treatment. Rotifers and crustacean assemblage, macrophytes coverage and environmental conditions were assessed in flow-through system within the medium-term scale in two artificial reservoirs. By comparison of results recorded during the summer 2008 and 2014 years we established few significant alterations: (i) increase of macrophyte coverage from 50  60% up to 98% with prevalence of uniform species composition of Hippuris vulgaris and Potamogeton natans ; (ii) hypoxia and reduction processes in sediment due to the macrophytes and leaf litter degradation from the surrounding deciduous forest ; (iii) decrease of rotifers and total diversity ; (iv) rotifers and crustacean spatial distribution were remarkably changed considering ratio between vegetated and nonvegetated habitats. Results of our study point out that even on medium-term scale rotifers assemblage may confirm ecosystem major changes. Moreover, we suggested that excessive macrophytes coverage requests simultaneous analyses of water and sediment as well as applying the most suitable method in the lake restoration.
Distributed Indexing for Resource Discovery in P2P Networks (2009)

P2P networks facilitate people belonging to a community to share resources of interest. However, discovering resources in a large scale P2P network poses a number of challenges. Although distributed hash table (DHT) structured P2P networks have shown enhanced scalability in routing messages, they only support key based exact matches. This paper presents DIndex, a distributed indexing component that can be used in P2P networks in support of range queries. DIndex introduces the concept of search dimensions for partitioning a search space, and it organizes peer nodes in a three-layered structure. Experimental results show that, for aP2P network with N number of peers, the average number of hops per message is less than log(N).
International Aspects: National Profiles, S witzerland (2000)

Introduction




Paving the Way for the Development of Swiss Biotechnology




Organization and Goals of the SPP BioTech




Achievements and Impacts of the SPP BioTech




Research Network in Biotechnology




Funding of Research in Biotechnology






Using Research Results to Create New Jobs




Technology Transfer—The universities as Partners for Private Industry






The Diversified and Rapidly Growing Swiss Biotech Industry




Finance




Safety and Transparency When Introducing Technological Innovations into Society




Successful launch of Swiss Biosafety Research Network




Biosafety, Technology Assessment and Tansdisciplnary Sustainability Management




Making Scientific Knowledge Available to Society








Regulatory Framework and Public Debate in Biotechnology




Swiss Citizens Against a Ban on Genetic Engineering




Ethics of Nonhuman Applications of Biotechnology




Regulatory Framework for Biotechnology Applications on Humans




Technology, Law, and Society







Keywords:

international aspects: national profiles, Switzerland
Precision medicine for metastatic colorectal cancer: an evolving era (2019)

<b>Introduction</b>: Metastatic colorectal cancer (CRC) remains a dilemma for cancer researchers with an increasing incidence in the younger patient population. Until the last decade, limited therapeutic options were available for metastatic CRC patients leading to relatively poor clinical outcomes.<b>Areas covered</b>: With advances in genome sequencing technology and reductions in the cost of next-generation sequencing, molecular profiling has become more accessible for cancer researchers and clinical investigators, which has furthered our understanding of the molecular behavior of CRC. This progress has recently translated into significant advances in molecular-based therapeutics and led to the development of new target-specific agents in metastatic CRC patients. In this review article, we extensively elaborate on genomic alterations seen in CRC patients including, but not limited to, EGFR, MMR, BRAF, HER2, NTRKs, FGFR, BRCA1/2, PALB2, POLE, and POLD1 genes, all of which are potentially actionable by either an FDA-approved agent or in a clinical trial setting.<b>Expert opinion</b>: We strongly recommend molecular profiling in metastatic CRC patients during the early course of their disease, as this may provide therapeutic and prognostic information that can guide clinicians to practice precision medicine. Patients with potentially actionable genes should be considered for targeting agents based on molecular alterations.
Sharp thresholds For monotone properties in random geometric graphs (2004)

Random geometric graphs result from taking n uniformly distributed points in the unit cube, [0,1]d, and connecting two points if their Euclidean distance is at most r, for some prescribed r. We show that monotone properties for this class of graphs have sharp thresholds by reducing the problem to bounding the bottleneck matching on two sets of $n$ points distributed uniformly in [0,1]d. We present upper bounds on the threshold width, and show that our bound is sharp for d = 1 and at most a sublogarithmic factor away for d ≥ 2. Interestingly, the threshold width is much sharper for random geometric graphs than for Bernoulli random graphs. Further, a random geometric graph is shown to be a subgraph, with high probability, of another independently drawn random geometric graph with a slightly larger radius; this property is shown to have no analogue for Bernoulli random graphs.
Influence of the epitaxial layer structure on the beam quality factor of tapered semiconductor amplifiers (1997)

In the last years, very good results have been demonstrated in the field of high power diffraction limited tapered semiconductor lasers and amplifiers. However, to our knowledge, no work was reported on the correlation between the epi-structure and the beam quality. In this paper, we discuss the reasons why different epitaxial layers are not equivalent from the beam quality point of view. We then report measurements made on semiconductor amplifiers of different wafers showing that the choice of the epitaxial structure is crucial to obtain good beam quality.
Acquirement of hairpin ribozyme activity by the long substrate-binding site. (1993)

Three hairpin ribozymes were designed to cleave Escherichia coli beta-glucuronidase (GUS) mRNA at a target site. Two of the designed ribozymes (HG10L and HG10L2) had long substrate binding sites and the other (HG10) had short substrate binding site. All three ribozymes cleaved the substrate, and HG10L and HG10L2 cleaved it efficiently. However, HG10 had very low activity. Effect of length of substrate binding site of the ribozyme will be discussed.
A 2-GHz 1.6-mW phase-locked loop (2002)

High-speed low-power phase-locked loops (PLLs) are an integral part of frequency synthesizers and clock recovery circuits. This paper describes the design of a 2 GHz PLL that employs a number of circuit techniques to reduce the power dissipation to 1.6 mW with a 3 V supply. Fabricated in an 18 GHz 0.6 /spl mu/m BiCMOS technology, the PLL utilizes fully-differential signals to improve the rejection of common-mode disturbances. The PLL design has a fairly standard architecture, but with the phase detector, the low-pass filter (LPF), and the voltage-controlled oscillator (VCO) merged so as to save power dissipation. The amplifier interposed between the LPF and the VCO operates at low frequencies, thus consuming negligible power.
A GFP-based System to Uncouple mRNA Transport from Translation in a Single Living Neuron (2003)

An inducible fluorescent system based on GFP is presented that allows for the uncoupling of dendritic mRNA transport from subsequent protein synthesis at the single cell level. The iron-responsive element (IRE) derived from ferritin mRNA in the 5'-UTR of the GFP reporter mRNA renders translation of its mRNA dependent on iron. The addition of the full-length 3'-UTR of the Ca(2+)/calmodulin-dependent protein kinase II alpha (CaMKIIalpha) after the stop codon of the GFP reading frame targets the reporter mRNA to dendrites of transfected fully polarized hippocampal neurons. As we show by time-lapse videomicroscopy, iron specifically turns on GFP reporter protein synthesis in a single transfected hippocampal neuron. We investigate whether GFP expression is affected--in addition to iron--by synaptic activity. Interestingly, synaptic activity has a clear stimulatory effect. Most importantly, however, this activity-dependent protein synthesis is critically dependent on the presence of the full-length 3'-UTR of CaMKIIalpha confirming that this sequence contains translational activation signals. The IRE-based system represents a new convenient tool to study local protein synthesis in mammalian cells where mRNA localization to a specific intracellular compartment occurs.
The Sweetening of the World's Diet (2003)

Caloric sweetener use has increased considerably around the world. Beverage intake seems to be a major contributor.
Generating microwave pulses with plasma (2016)

Summary form only given. The control of electromagnetic radiation with plasmas is studied in a microwave resonant cavity fabricated using additive manufacturing and copper electroplating. The resonant cavity is created between two conducting posts in a rectangular waveguide at 12.3 GHz and scattering parameters of electromagnetic radiation are measured using a vector network analyzer. Plasma is introduced in the resonator in order to change the refractive index; control of the discharge voltage varies the frequency response. The plasma is also pulsed to create a time varying electron density and resonance frequency. In this way microwave pulses can be formed from a continuous microwave input, and the output pulse's width and delay can be controlled by the input microwave frequency.
Analysis of tocopherols by capillary supercritical fluid chromatography and mass spectrometry (1993)

Tocopherol‐containing mixtures were analyzed by gas chromatography (GC) and capillary supercritical fluid chromatography (SFC). GC analysis of tocopherols required the formation of the silyl derivatives, while SFC analysis of the tocopherol‐containing mixtures was accomplished on neat samples. SFC analysis conditions were optimized with respect to column type and density/pressure programming. Enhanced resolution of many components was achieved by using inverse temperature programming during the SFC analyses. Both SFC and GC analyses permitted the separation and quantitation of alpha‐, beta‐, gamma‐ and delta‐tocopherols. In addition, SFC proved particularly applicable for characterizing the composition of a deodorizer distillate and commercial antioxidant formulation. Coupling of a quadrapole mass spectrometer with a supercritical fluid chromatograph was also achieved; the mass spectrometer provided electron impact mass spectra on the underivatized tocopherol and sterol moieties. Both SFC and SFC/mass spectrometry proved effective for the analysis of complex lipid‐containing mixtures, requiring minimal sample preparation prior to analysis.
APOIO EMOCIONAL OFERECIDO ÀS PARTURIENTES: OPINIÃO DAS DOULAS (2013)

RESUMO Objetivou-se descrever o perfil sociodemografico das doulas e verificar a opiniao destas sobre o apoio emocional oferecido as parturientes assistidas em uma maternidade filantropica localizada na zona sul da cidade de Sao Paulo (SP). Estudo descritivo, com abordagem quantitativa, com uma amostra de 28 doulas, definida por conveniencia. Os dados foram coletados por meio de um questionario semiestruturado, no periodo de julho a setembro de 2012, e analisados utilizando-se a estatistica descritiva. Observou-se que as participantes da pesquisa eram predominantemente mulheres com idade igual ou superior a 42 anos, casadas, com nivel superior de educacao. Constatou-se que as doulas acreditam que o apoio emocional promove mudancas beneficas para a assistencia nao apenas a parturiente, mas tambem para os profissionais de saude e para a instituicao de saude, e que sua insercao no cenario do nascimento fundamenta a ideia de humanizacao da assistencia ao parto. Descritores: Parto. Conhecimentos, atitudes e praticas em saude. Saude da mulher. Parto Humanizado.
A Nonlinear Optimization Technique of Tunnel Construction Based on DE and LSSVM (2013)

Tunnel construction is a dynamic controlling system with observability and controllability; the feedback analysis requires identifying geophysics parameters and adjusting supporting parameters, and both of them are optimisation problems. The paper proposed a nonlinear optimization technique based on difference evolution arithmetic (DEA), least square support vector machine (LSSVM), and three dimensional numerical simulation. This method employs support vector machine with optimal architecture trained by the difference evolution arithmetic, instead of the time-consuming finite element analysis. Firstly, the three dimensional numerical simulation is used to create training and testing samples for LSSVM model construction. Then the nonlinear relationship between rock or anchoring parameters and displacement is constructed by support vector machine. Finally, the geophysics and supporting parameters are obtained by DE optimization arithmetic. The technique overcomes the conventional optimization method shortages of expending too much computing time and easily being limited in local optimal solution. This technique was verified by applying it to the feedback analysis of Dalian Metro in China, and the influence of the parameters of LSSVM and DE on the simulation ability of the algorithm was investigated.
Dr. Johan Rudolf Katz 1880-1938 (1939)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDr. Johan Rudolf Katz 1880-1938E Heuser and B. W. Rowland Cite this: J. Chem. Educ. 1939, 16, 4, 153Publication Date (Print):April 1, 1939Publication History Received3 August 2009Published online1 April 1939Published inissue 1 April 1939https://doi.org/10.1021/ed016p153RIGHTS & PERMISSIONSArticle Views28Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-Alerts Get e-Alerts
A toolbox of genes, proteins, metabolites and promoters for improving drought tolerance in soybean includes the metabolite coumestrol and stomatal development genes (2016)

Our toolbox provides new targets and strategies for improving soybean drought tolerance and includes the coumestan coumestrol, transcription factors that regulate stomatal density, water stress-responsive WRKY gene promoters and a novel DNA element that appears to be enriched in water stress responsive promoters.
New Inhibitors of 3.ALPHA.-Hydroxysteroid Dehydrogenase, 0231A and 0231B from Streptomyces sp. HKI 0231. (2001)

3a-Hydroxysteroid dehydrogenase is one of the key enzymes involved in inflammatory processes^. Hence, inhibitors of this enzymeare interesting as lead structures for the development of anti-inflammatory agents. In a screening for new microbial metabolites inhibiting 3ahydroxysteroid dehydrogenase we disclosed Streptomyces sp. HKI 0231 as the producer of new inhibitors, 0231A (1) pp.510 -512 and 023IB (2). Both compounds were formed as minor components in addition to angucyclin-type metabolites
Design and implementation of a high power three-level T-type inverter for a photovoltaic system (2015)

Nowadays, the grid-connected photovoltaic systems are an important part of the renewable energy sources, and their performance is getting more and more important. Many reported researches focused on the traditional NPC topology. However, few researches were about the T-type NPC inverter. In this paper, a high power three-phase T-type neutral point clamped grid connected photovoltaic inverter prototype is designed and implemented. The design and implementation procedure of the inverter is discussed in detail. Experimental results showed that the output power of the proposed inverter could reach up to 100kW with unit power factor, while the total harmonic distortion of the grid current was less than 3%. And the total efficiency of the system is measured as 95.6%. The experimental results demonstrated the T-type NPC inverter can operate with a good performance.
Temperature-dependent Ionic polymer-metal composite (IPMC) sensing dynamics: Modeling and inverse compensation (2010)

Ionic polymer-metal composites (IPMCs) have intrinsic sensing capabilities. Like many other sensing materials, however, IPMC sensors demonstrate strong temperature-dependent behaviors. In this paper we present the first systematic studies on temperature-dependent IPMC sensing dynamics. A cantilevered IPMC beam, soaked in a water bath with controlled temperature, is excited mechanically at its tip at frequencies of 10-100 Hz. The empirical frequency response of the sensor, with the tip displacement as input and the short-circuit current as output, shows clear dependence on the bath temperature. The sensing dynamics is modeled with a transfer function with temperature-dependent coefficients. By fitting the values of the coefficients at a set of test temperatures, we capture the temperature-dependence of the coefficients with polynomial functions, which can be used to predict the sensing dynamics at other temperatures. We further investigate the inversion of the sensing dynamics, for extracting the mechanical signal given the sensor output. In particular, a stable but noncausal inversion algorithm is applied to deal with the unstable zeros of the original sensing dynamics. Experimental results with both harmonic stimuli and free vibrations have validated the effectiveness of the proposed modeling and inversion schemes for IPMC sensors under different temperatures.
C.EcoO109I, a regulatory protein for production of EcoO109I restriction endonuclease, specifically binds to and bends DNA upstream of its translational start site (2002)

The EcoO109I restriction-modification system, which recognizes 5'-(A/G)GGNCC(C/T)-3', has been cloned, and contains convergently transcribed endonuclease and methylase. The role and action mechanism of the gene product, C.EcoO109I, of a small open reading frame located upstream of ecoO109IR were investigated in vivo and in vitro. The results of deletion analysis suggested that C.EcoO109I acts as a positive regulator of ecoO109IR expression but has little effect on ecoO109IM expression. Assaying of promoter activity showed that the expression of ecoO109IC was regulated by its own gene product, C.EcoO109I. C.EcoO109I was overproduced as a His-tag fusion protein in recombinant Escherichia coli HB101 and purified to homogeneity. C.EcoO109I exists as a homodimer, and recognizes and binds to the DNA sequence 5'-CTAAG(N)(5)CTTAG-3' upstream of the ecoO109IC translational start site. It was also shown that C.EcoO109I bent the target DNA by 54 +/- 4 degrees.
Simulation of Nickel Morphological and Crystal Structures Evolution in Solid Oxide Fuel Cell Anode Using Phase Field Method (2014)

In the present study, a phase field method is used to simulate the morphological and crystal structural evolution of nickel-yttria stabilized zirconia composite anode of solid oxide fuel cell based on three-dimensional microstructures reconstructed by focused ion beam-scanning-electron-microscopy technique. A three-dimensional reconstruction of the anode sample after initial reduction is used as the initial microstructure. In order to simulate the nickel crystal grain growth and the corresponding morphological change at the same time, both material composition and crystallographic orientation order parameters are introduced in the model. In order to quantitatively study the nickel coarsening effect on anode performance, the evolution of three-phase boundary density and nickel specific surface area are quantitatively calculated in the simulations. Simulation results reproduced well the initial microstructural evolution in the experiments.
Effect of growth temperature on the synthesis of carbon nanotube arrays and amorphous carbon for thermal applications (2017)

Though carbon nanotube (CNT) arrays have tremendous potential due to their attractive mechanical, electrical, and thermal properties, the growth kinetics of CNTs are still not fully understood. Thus, we report on the effect of synthesis parameters, such as growth temperature, on the resulting arrays. In this work, CNT arrays were synthesized using catalytic chemical vapor deposition (CCVD) with furnace temperatures varying from 680 to 900 °C. Microscopy was used to investigate the effect of growth temperature on the structural properties, such as tube diameter, array length, and the amount of amorphous carbon produced at the top of the canopy as a growth by‐product. Additionally, Raman spectroscopy was used to elucidate the effect growth temperature has on the resulting purity of the CNTs. It was then revealed that crystalline inhomogeneity exists along the length of the tubes with respect to crystallinity. Transmission electron microscopy (TEM) further determines the degree of tube crystallinity as well as the thickness of amorphous carbon coating around the nanotubes. Through both microscopy and spectroscopy, we found two distinct temperature regimes within the range of 680–900 °C. Below 800 °C, the growth of tube length and diameter remained relatively stagnant followed by a rapid growth rate above 800 °C with the highest tube crystallinity obtained within the regime of 800–840 °C. This indicates the presence of an important transitional temperature for CNT CCVD growth. Additionally, growth temperature was determined to play an important role in the amount of the resulting amorphous carbon by‐product.