gebhart/patrepeval huggingface dataset:
Visual Deprivation Modifies Both Presynaptic Glutamate Release and the Composition of Perisynaptic/Extrasynaptic NMDA Receptors in Adult Visual Cortex (2005)

Use-dependent modifications of synapses have been well described in the developing visual cortex, but the ability for experience to modify synapses in the adult visual cortex is poorly understood. We found that 10 d of late-onset visual deprivation modifies both presynaptic and postsynaptic elements at the layer 4-->2/3 connection in the visual cortex of adult mice, and these changes differ from those observed in juveniles. Although visual deprivation in juvenile mice modifies the subunit composition and increases the current duration of synaptic NMDA receptors (NMDARs), no such effect is observed at synapses between layer 4 and layer 2/3 pyramidal neurons in adult mice. Surprisingly, visual deprivation in adult mice enhances the temporal summation of NMDAR-mediated currents induced by bursts of high-frequency stimulation. The enhanced temporal summation of NMDAR-mediated currents in deprived cortex could not be explained by a reduction in the rate of synaptic depression, because our data indicate that late-onset visual deprivation actually increases the rate of synaptic depression. Biochemical and electrophysiological evidence instead suggest that the enhanced temporal summation in adult mice could be accounted for by a change in the molecular composition of NMDARs at perisynaptic/extrasynaptic sites. Our data demonstrate that the experience-dependent modifications observed in the adult visual cortex are different from those observed during development. These differences may help to explain the unique consequences of sensory deprivation on plasticity in the developing versus mature cortex.
Logic synthesis of controllers for B-ternary asynchronous systems (2002)

Asynchronous digital circuits and self-timed circuits are receiving attention due to the rapid development of VLSI technology and the difficulty of global clock distribution. In addition, an asynchronous system consumes lower power because unused parts of the system are deactivated, and the computational time is average-case instead of worst-case. In this paper, a logic synthesis approach for designing the controller for a B-ternary data-path we have presented earlier is discussed. To control the B-ternary data-path asynchronously, external-binary, internal-ternary signaling is required. We derive an asynchronous state transition graph from the signal transition graph of the controller and then synthesize a hazard-free asynchronous implementation of the controller as a two-level combinational circuit together with a ternary-in binary-out C-element.
Development of converters for improving efficiency and achieving both power factor correction and fast output regulation (1999)

Development of converters for improving efficiency and achieving both fast regulation and power factor correction (PFC) is presented in the paper. A general configuration is first introduced, and, then, the degenerated configurations are derived according to the variation of power-split ratios. With these configurations, not only the converter systems discussed in literature can be developed alternatively, but novel converters can be synthesized. In addition, power-split and power-combination configurations are introduced to help the development of converter systems, resulting in more physical insights into the system configurations. With the concept of energy partial processing, overall conversion efficiency is improved, while PFC and fast regulation can still be achieved effectively.
Low-Temperature Metalorganic Vapor Phase Epitaxy (MOVPE) of GaN using Tertiarybutylhydrazine (1999)

Tertiarybutylhydrazine was used as a novel nitrogen source for metalorganic vapor phase epitaxy of GaN at low temperatures. Hexagonal epilayers with optically smooth and specular surfaces were grown with trimethylgallium on basal plane sapphire as well as GaAs(111) B substrates. On (001)-oriented GaAs, predominantly cubic GaN was grown. Incorporation of carbon impurities was distinctly lower than in layers grown with dimethylhydrazine. The epilayer quality is presently limited by the purity of the available tertiarybutylhydrazine.
More than magnetic isolation: Dynabeads as strong Raman reporters towards simultaneous capture and identification of targets. (2023)

Dynabeads are superparamagnetic particles used for immunomagnetic purification of cells and biomolecules. Post-capture, however, target identification relies on tedious culturing, fluorescence staining and/or target amplification. Raman spectroscopy presents a rapid detection alternative, but current implementations target cells themselves with weak Raman signals. We present antibody-coated Dynabeads as strong Raman reporter labels whose effect can be considered a Raman parallel of immunofluorescent probes. Recent developments in techniques for separating target-bound Dynabeads from unbound Dynabeads makes such an implementation feasible with high specificity. We deploy Dynabeads anti<i>-Salmonella</i> to bind and identify <i>Salmonella enterica,</i> a major foodborne pathogen. Dynabeads present major peaks around 1000 and 1600 cm<sup>-1</sup> from aliphatic and aromatic C-C stretching of the polystyrene coating and near 1350 cm<sup>-1</sup> from the ɣ-Fe<sub>2</sub>O<sub>3</sub> and Fe<sub>3</sub>O<sub>4</sub> core, confirmed with electron dispersive X-ray (EDX) imaging. Minor to no contributions are made from the surface antibodies themselves as confirmed by Raman analysis of surface-activated, antibody-free beads. Dynabeads' Raman signature can be measured in dry and liquid samples even at single shot ~30 × 30 <i>μ</i>m area imaging using 0.5 s, 7 mW laser acquisition with single and clustered beads providing a 44- and 68-fold larger Raman intensity compared to signature from cells. Higher polystyrene and iron oxide content in clusters yields larger signal intensity and conjugation to bacteria strengthens clustering as a bacterium can bind to more than one bead as observed via transmission electron microscopy (TEM). Our findings shed light on the intrinsic Raman reporter nature of Dynabeads. When combined with emerging techniques for the separation of target-bound Dynabeads from unbound Dynabeads such as using centrifugation through a density media bi-layer, they have potential to demonstrate their dual function for target isolation and detection without tedious staining steps or unique plasmonic substrate engineering, advancing their applications in heterogeneous samples like food, water, and blood.
CompRet: A Comprehensive Recommendation Framework for Chemical Synthesis Planning with Algorithmic Enumeration (2020)

In computer-assisted synthesis planning (CASP) programs, providing chemical synthetic routes as many as possible is essential for considering optimal and alternative routes in a chemical reaction network. As the majority of CASP programs have been designed to provide one or a few optimal routes, it is likely that desired one will not be included. To avoid this, an exact algorithm that lists possible synthetic routes from the chemical reaction network is required, alongside a recommendation of synthetic routes that meet specified criteria based on chemist's objectives. Herein, we propose a chemical-reaction-network-based synthetic route recommendation framework called "CompRet" with a mathematically guaranteed enumeration algorithm. In a preliminary experiment, CompRet was shown to successfully provide alternative routes for a known antihistaminic drug, cetirizine. CompRet is expected to promote desirable enumeration-based chemical synthesis searches and aid the development of an interactive CASP framework for chemists.
A localized current field hyperthermia system for use with 192-iridium interstitial implants (1982)

The efficacy of localized current field (LCF) hyperthermia as an adjunct to 192Ir interstitial implantation of tumors is currently under investigation. In this article, we describe an experimental LCF system suitable for such investigations, and discuss some of the physical and biological parameters pertinent to its design and safe operation.
EinStein Würfelt Nicht – An Analysis of Endgame Play (2012)

The 16th Computer Olympiad held in Tilburg in 2011 was the first (and possibly last) Olympiad to see a competition in the game EinStein Würfelt Nicht (EWN). In this note, we discuss the solution of endgame positions for this game and use tablebases o
Development of a Generic Time-to-Contact Pilot Guidance Model (2017)

The time-to-contact theory posits that purposeful actions can be conducted by coupling the actor’s motion onto the so-called guides generated internally by their central nervous system. Although significant advances have been made in the application of for flight control purposes, little research has been conducted to investigate how pilots are able to adapt their -guidance strategy to different aircraft dynamics, or how a -guide-based pilot–aircraft model might be used to represent control behavior. This paper reports on the development of such a model to characterize the adaptation of pilot guidance to variations in aircraft dynamics using data obtained from a clinical pilot-in-the-loop flight simulation experiment. The results indicate that pilots tend to maintain a constant coupling between the dynamic system’s motion and the guide across a range of different configuration parameters. Simultaneously, the pilot modulates the guidance maneuver period to adapt to these different aircraft dynamics that result in changes in workload. Modeling the complete pilot stabilization and guidance function as a regulator plus inverter yields good comparative results between the pilot–aircraft model and simulator trajectory data, and it supports the hypothesis that the following -based guidance strategies suppress an aircraft’s natural dynamics.
Common action of certain viruses, toxins, and activated complement: pore formation and its prevention by extracellular Ca2+ (1984)

Haemolysis by Sendai virus, alpha-toxin, and activated complement is inhibited by high concentrations of divalent cations. In Daudi cells, sublytic amounts of these agents induce the following changes: collapse of surface membrane potential, uptake of Na+ and loss of K+ from cells, and leakage of phosphorylated metabolites from cells. The changes induced by Sendai virus and complement are sensitive to physiological concentrations of extracellular Ca2+. It is concluded that fluctuations in plasma Ca2+ concentration may affect the damaging action of certain pore-forming agents on susceptible cells.
The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity (2015)

ATP-binding cassette transporter G1 (ABCG1) promotes cholesterol efflux from cells and regulates intracellular cholesterol homeostasis. Here we demonstrate a role of ABCG1 as a mediator of tumour immunity. Abcg1(-/-) mice have dramatically suppressed subcutaneous MB49-bladder carcinoma and B16-melanoma growth and prolonged survival. We show that reduced tumour growth in Abcg1(-/-) mice is myeloid cell intrinsic and is associated with a phenotypic shift of the macrophages from a tumour-promoting M2 to a tumour-fighting M1 within the tumour. Abcg1(-/-) macrophages exhibit an intrinsic bias towards M1 polarization with increased NF-κB activation and direct cytotoxicity for tumour cells in vitro. Overall, our study demonstrates that the absence of ABCG1 inhibits tumour growth through modulation of macrophage function within the tumour, and illustrates a link between cholesterol homeostasis and cancer.
Chemical composition and Biological studies of Ficus benjamina (2014)

Considering these results, it is concluded that F. benjamina can be used as a potential source for the exploration of new antioxidant compounds and antimicrobial agents.
Comparative sensitivity analysis of integrated optical waveguides for near-infrared volatile organic compounds with 1ppb detection (2014)

We compared different on-chip silicon waveguide based absorption sensors for the detection of xylene in water in nearinfrared with detection limit down to 1ppb. Strip waveguide, slot waveguide and PC-based chip integrated optical absorption spectroscopy devices are compared in near-infrared. PCW utilizes slow light effect to enhance absorbance and is most sensitive while slot waveguide strengthens light-matter interaction in a narrow low index slot by a factor up to 10 and performs better than a strip waveguide. The results provide a route for enhanced sensitivity via absorption spectroscopy while retaining device miniaturization.
Urocortin Expression in Endometriosis: A Systematic Review. (2019)

Urocortin (UCN) is a neuropeptide that belongs to the corticotrophin-releasing hormone family and is expressed by eutopic and ectopic human endometria. The past years, this expression has been thoroughly investigated in the field of endometriosis. The objective of this systematic review is to accumulate current evidence related to the expression of UCN in tissue and blood samples of patients suffering from endometriosis. Literature search was designed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and primarily conducted using the Medline (1966-2018), Scopus (2004-2018), EMBASE (1947-2018) and Clinicaltrials.gov (2008- 2018) databases, along with the reference lists of electronically retrieved full-text papers. Overall, eight studies were retrieved. Current evidence suggests that the expression of UCN is increased in patients with ovarian endometriomas and that its levels may correlate with the severity of the disease. The diagnostic efficacy of UCN1 plasma levels was evaluated in three studies. Two of them suggested that the sensitivity and specificity of the method may reach, and even exceed, 80%. However, the wide variation in outcome reporting and outcome reporting measures in endometriosis among the included studies precludes meta-analysis of available data. Therefore, although UCN seems to be a promising biomarker for the identification and follow-up of patients that suffer from endometriosis, more studies are needed to reach firm conclusions with respect to its predictive accuracy.
Proteolipids. IV. Formation of Complexes between Cytochrome c and Purified Phospholipids* (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProteolipids. IV. Formation of Complexes between Cytochrome c and Purified Phospholipids*M. L. Das, E. D. Haak, and F. L. CraneCite this: Biochemistry 1965, 4, 5, 859–865Publication Date (Print):May 1, 1965Publication History Published online1 May 2002Published inissue 1 May 1965https://pubs.acs.org/doi/10.1021/bi00881a010https://doi.org/10.1021/bi00881a010research-articleACS PublicationsRequest reuse permissionsArticle Views26Altmetric-Citations58LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Phase-only blind deconvolution using bicepstrum iterative reconstruction algorithm (BIRA) (1996)

In this correspondence, we propose a procedure based on the bicepstrum iterative reconstruction algorithm (BIRA) for the reconstruction of an input signal (unobservable) of a linear-phase or zero-phase linear time-invariant (LTI) system from its observed output. The desired input signal is reconstructed without the knowledge of the system transfer function.
P2‐274: MUSCLE PROFILE AND PROGRESSION OF ALZHEIMER'S DEMENTIA: PREDICTORS OF POOR CLINICAL OUTCOME AND ROLE OF MUSCLE PROFILE, A 3‐YEAR LONGITUDINAL STUDY (2019)

Although many factors are known to affect the rate of cognitive decline, studies on clinical outcomes are rare. Moreover, muscle mass profiles and their relationship to dementia trajectories have not been extensively investigated. We investigated factors which affect the rate of clinical decline and the usefulness of muscle profiles for predicting the clinical outcomes of dementia patients with Alzheimer's dementia (AD). Sixty-nine subjects with probable AD, but without muscle weakness, were included this study. Variables including age, years of education, hypertension, diabetes mellitus, lacunar infarcts, baseline cognition, muscle mass, and strength were assessed during the initial visit of each subject. Over a period of three years, each subject received an annual evaluation that included a clinical interview and an assessment of their cognitive status as measured by a Clinical Dementia Rating – Sum of Boxes (CDR-SOB) score. Linear mixed-effects models were used to test for associations between each factor and the CDR-SOB score over time. These analyses were then repeated in a multivariate linear mixed-effects model after adjusting the covariates. Age, DM, and baseline severity were identified as potential covariates that influence clinical progression; however, a subject's muscle profile was not found to predict dementia progression. We expect that early screening and intervention, as well as new drugs with mechanisms of action similar to those of antidiabetic medications, will help patients with dementia maintain their clinical status.
Hybrid Cooperative Positioning for Vehicular Networks (2019)

This paper proposes a hybrid cooperative positioning (CP) algorithm suitable for vehicular network applications which can fuse the measurements from global navigation satellites, ground stations, signals of opportunity, inter-node ranging from neighbouring vehicles and onboard inertial navigation systems (INS). By applying the framework of generalized approximate message passing (GAMP), the complex CP problem is transformed into an iterative yet lower computational load process. In each iteration, the time recurrence of navigation states and initialization of GAMP computation are conducted based on Kalman filter. The proposed algorithm guarantees the overall positioning performance of multiple vehicles in a hybrid navigation scenario, and improves the robustness and accuracy of CP navigation systems. Simulation results show that the proposed algorithm has better estimation accuracy than traditional CP algorithms, and has 20 times less computational load than the best existing algorithm with equivalent accuracy.
Heart Failure During Cardiac Pacing (2006)

Differences in HFH risk can be explained by interactions between substrate (atrial fibrillation, AV conduction, heart failure, MI, EF) and pacing promoters (ventricular desynchronization-paced QRSd and Cum%VP, and AV desynchronization-pacing mode). Management of RVA pacing is important for reducing the risk of HFH, particularly among patients with low EF and heart failure.
A quasipolynomial (2 + ε )-approximation for planar sparsest cut (2021)

The (non-uniform) sparsest cut problem is the following graph-partitioning problem: given a “supply” graph, and demands on pairs of vertices, delete some subset of supply edges to minimize the ratio of the supply edges cut to the total demand of the pairs separated by this deletion. Despite much effort, there are only a handful of nontrivial classes of supply graphs for which constant-factor approximations are known.
Preliminary Report on Lichen-Feeding Coleoptera Occurring on Teloschistes capensis in the Namib Desert, South West Africa (1979)

D. C. J. Wessels, L. A. Wessels, W. H. Holzapfel, Preliminary Report on Lichen-Feeding Coleoptera Occurring on Teloschistes capensis in the Namib Desert, South West Africa, The Bryologist, Vol. 82, No. 2 (Summer, 1979), pp. 270-273
Carmustine (BCNU) plus Teniposide (VM26) in Recurrent Malignant Glioma (2014)

Our data do not support the application of BCNU/VM26 in patients with late stages of recurrent GBM.
Detection and purification of isoaccepting tRNAPhe species containing Y base by affinity chromatography on columns of anti-Y antibodies (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetection and purification of isoaccepting tRNAPhe species containing Y base by affinity chromatography on columns of anti-Y antibodiesR. Salomon, S. Fuchs, A. Aharonov, D. Giveon, and U. Z. LittauerCite this: Biochemistry 1975, 14, 18, 4046–4050Publication Date (Print):September 1, 1975Publication History Published online1 May 2002Published inissue 1 September 1975https://pubs.acs.org/doi/10.1021/bi00689a018https://doi.org/10.1021/bi00689a018research-articleACS PublicationsRequest reuse permissionsArticle Views26Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Bees as Biosensors: Chemosensory Ability, Honey Bee Monitoring Systems, and Emergent Sensor Technologies Derived from the Pollinator Syndrome (2015)

This review focuses on critical milestones in the development path for the use of bees, mainly honey bees and bumble bees, as sentinels and biosensors. These keystone species comprise the most abundant pollinators of agro-ecosystems. Pollinating 70%-80% of flowering terrestrial plants, bees and other insects propel the reproduction and survival of plants and themselves, as well as improve the quantity and quality of seeds, nuts, and fruits that feed birds, wildlife, and us. Flowers provide insects with energy, nutrients, and shelter, while pollinators are essential to global ecosystem productivity and stability. A rich and diverse milieu of chemical signals establishes and maintains this intimate partnership. Observations of bee odor search behavior extend back to Aristotle. In the past two decades great strides have been made in methods and instrumentation for the study and exploitation of bee search behavior and for examining intra-organismal chemical communication signals. In particular, bees can be trained to search for and localize sources for a variety of chemicals, which when coupled with emerging tracking and mapping technologies create novel potential for research, as well as bee and crop management.
A Method of Representing the Solid Design Process (1985)

Wish modeling systems were more user friendly? This one quickly regenerates a solid design from previous developmental stages to ease the usual trial-and-error procedurtes