gebhart/patrepeval huggingface dataset:
Adaptive multistage parallel interference cancellation for CDMA (1999)

Although the multistage interference cancellation detector is simple in structure, its performance degrades when the number of active users becomes large. In some cases, the performance is even worse than that without cancellation, due to the lack of the exact knowledge of the interfering signal in cancellation. Partial interference cancellation suggested by Divsalar and Simon (see IEEE Trans. Commun., vol.46, p.258-68, 1998) tries to remedy this weakness by reducing the cost of a wrong interference estimation through a weight in each stage. This paper presents an adaptive multistage structure based on the partial interference cancellation approach. In this structure, the weights are obtained by minimizing the mean-square error between the received signal and its estimate through a least mean square (LMS) algorithm. The resulting weights contain reliability information for the hard decisions made in the previous stage. Neither a training sequence nor a pilot signal is needed in the proposed scheme, and its complexity is much lower than that of linear multiuser detectors. Simulation results show that the proposed scheme can outperform some of the existing interference cancellation methods in both the additive white Gaussian noise (AWGN) and the multipath fading channels.
Improved graph computations on the reconfigurable mesh (2002)

The paper develops a data structure and data movement operations which lead to efficient parallel graph computations on the reconfigurable mesh. The technique computes a minimal spanning forest of a N/sup 1/2/ vertex graph in O(log N log log N) time given the adjacency matrix of the graph on a N/sup 1/2/*N/sup 1/2/ reconfigurable mesh. This improves over the known algorithms of O(log/sup 2/ N) time. The parallel technique can be modified to result in efficient parallel solutions to other graph problems such as checking whether the graph is biconnected, computing the articulation points and the cyclic index of the graph.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Turnover Temperatures for Doubly Rotated Quartz (1982)

Abstract : The turnover temperatures, Tto, of quartz plates vibrating in the thickness mode are calculated for doubly rotated orientations in the temperature range of -200 to +200 degrees C. In addition to the standard cuts of interest situated along the loci of zero values of the first order temperature coefficients of frequency, we find another family of doubly rotated quartz orientations, vibrating in c-mode resonance, with Tto values 70 degrees C and above. The significance of these orientations are that for the same Tto they are considerably less sensitive to crystallography orientation than currently utilized singly or doubly rotated cuts. For Tto = 90 degrees C, the static frequency as a function of temperature coefficients of these orientations are between the AT-cut and BT-cuts, and they become less sensitive to temperature with increasing Tto.
Feasibility study for clinical application of caspase‐3 inhibitors in Pemphigus vulgaris (2017)

The potentially severe side effects of systemic corticosteroids and immunosuppressants used in Pemphigus vulgaris (PV) call for novel therapeutic approaches. In this context, pharmacological inhibition of major pathogenic signalling effectors represents a promising alternative. However, we have also shown that overinhibition of effectors required for epidermal homeostasis can exacerbate PV pathophysiology implicating transepidermal keratinocyte fragility. A feedforward target validation therefore preferentially includes studies on knockout mouse models. We previously reported on successful amelioration of PV blisters following inhibition of non-apoptotic, low-level caspase-3. Here, we use conditional, keratinocyte-specific caspase-3-deficient mice (casp3<sup>EKO</sup> ) to demonstrate (i) absence of keratinocyte fragility upon injection of the potent Dsg3-specific antibody AK23 and (ii) amelioration of blistering on the background of known signalling effectors. Our results provide the experimental proof of concept justifying translation of the caspase-3 inhibitor approach into PV clinical trials.
Static Characteristics of the Digital PWM and/or PFM Controlled Switching DC-DC Converters (2007)

The digitally controlled dc-dc converter has the advantage of high reliability, high controllability and high flexibility. A new digital controller for the PWM and/or PFM controlled switching dc-dc converters is presented, which is versatile in general use such as the switching frequency from 20kHz to 70kHz, the hard-switching and soft-switching and so forth. As an example, we apply this controller to half-bridge type series resonant dc-dc converter with auxiliary switches, in which both PWM and PFM control modes are employed, and the output characteristics of the converter are discussed. As a result, the relationships among circuit parameters of the proposed digital controller, switching frequency of the dc-dc converter, oscillation frequency of the VCO as analog to digital signal converter are defined.
Plasma Sphingomyelin Level as a Risk Factor for Coronary Artery Disease (2000)

Only a fraction of the clinical complications of atherosclerosis are explained by known risk factors. Animal studies have shown that plasma sphingomyelin (SM) levels are closely related to the development of atherosclerosis. SM carried into the arterial wall on atherogenic lipoproteins may be locally hydrolyzed by sphingomyelinase, promoting lipoprotein aggregation and macrophage foam cell formation. A novel, high-throughput, enzymatic method to measure plasma SM levels has been developed. Plasma SM levels were related to the presence of coronary artery disease (CAD) in a biethnic angiographic case-control study (279 cases and 277 controls). Plasma SM levels were higher in CAD patients than in control subjects (60+/-29 versus 49+/-21 mg/dL, respectively; P:<0. 0001). Moreover, the ratio of SM to SM+phosphatidylcholine (PC) was also significantly higher in cases than in controls (0.33+/-0.13 versus 0.29+/-0.10, respectively; P:<0.0001). Similar relationships were observed in African Americans and whites. Plasma SM levels showed a significant correlation with remnant cholesterol levels (r=0.51, P:<0.0001). By use of multivariate logistic regression analysis, plasma SM levels and the SM/(SM+PC) ratio were found to have independent predictive value for CAD after adjusting for other risk factors, including remnants. The odds ratio (OR) for CAD was significantly higher for the third and fourth quartiles of plasma SM levels (OR 2.81 [95% CI 1.66 to 4.80] and OR 2.33 [95% CI 1.38 to 3. 92], respectively) as well as the SM/(SM+PC) ratio (OR 1.95 [95% CI 1.10 to 3.45] and OR 2.33 [95% CI 1.34 to 4.05], respectively). The findings indicate that human plasma SM levels are positively and independently related to CAD. Plasma SM levels could be a marker for atherogenic remnant lipoprotein accumulation and may predict lipoprotein susceptibility to arterial wall sphingomyelinase.
Solvate Structures and Spectroscopic Characterization of LiTFSI Electrolytes (2014)

A Raman spectroscopic evaluation of numerous crystalline solvates with lithium bis(trifluoromethanesulfonyl)imide (LiTFSI or LiN(SO2CF3)2) has been conducted over a wide temperature range. Four new crystalline solvate structures-(PHEN)3:LiTFSI, (2,9-DMPHEN)2:LiTFSI, (G3)1:LiTFSI and (2,6-DMPy)1/2:LiTFSI with phenanthroline, 2,9-dimethyl[1,10]phenanthroline, triglyme, and 2,6-dimethylpyridine, respectively-have been determined to aid in this study. The spectroscopic data have been correlated with varying modes of TFSI(-)···Li(+) cation coordination within the solvate structures to create an electrolyte characterization tool to facilitate the Raman band deconvolution assignments for the determination of ionic association interactions within electrolytes containing LiTFSI. It is found, however, that significant difficulties may be encountered when identifying the distributions of specific forms of TFSI(-) anion coordination present in liquid electrolyte mixtures due to the wide range of TFSI(-)···Li(+) cation interactions possible and the overlap of the corresponding spectroscopic data signatures.
Origami Actuator Design and Networking Through Crease Topology Optimization (2015)

Origami structures morph between 2D and 3D conformations along predetermined fold lines that efficiently program the form of the structure and show potential for many engineering applications. However, the enormity of the design space and the complex relationship between origami-based geometries and engineering metrics place a severe limitation on design strategies based on intuition. The presented work proposes a systematic design method using topology optimization to distribute foldline properties within a reference crease pattern, adding or removing folds through optimization, for a mechanism design. Optimization techniques and mechanical analysis are co-utilized to identify an action origami building block and determine the optimal network connectivity between multiple actuators. Foldable structures are modeled as pin-joint truss structures with additional constraints on fold, or dihedral, angles. A continuous tuning of foldline stiffness leads to a rigid-to-compliant transformation of the local foldline property, the combination of which results in origami crease design optimization. The performance of a designed origami mechanism is evaluated in 3D by applying prescribed forces and finding displacements at set locations. A constraint on the number of foldlines is used to tune design complexity, highlighting the value-add of an optimization approach. Together, these results underscore that the optimization of function, in addition to shape, is a promising approach to origami design and motivates the further development of function-based origami design tools.
Association of spinal deformity and vaccine‐induced abdominal lesions in harvest‐sized Atlantic salmon, Salmo salar L. (2008)

Spinal deformities in Atlantic salmon, Salmo salar L., have been described as a disease of multifactorial origin for which vaccines and time of vaccination have been suggested as risk factors. A vaccine efficacy trial where spinal deformity became evident was continued by the observational study reported here. In the preharvest part of the study 17 months post-sea transfer, there was a prevalence of 11.3% spinal deformity, with deformities present only in one vaccine group indicating a strong vaccine involvement. At slaughter, the prevalence of spinal deformities was 11.7%, and deformed fish had only 62% of normal slaughter weight. Visual analogue scales (VAS) were used for continuous recordings of vaccine-induced abdominal lesions and deformity. A logistic regression model associating presence of spinal deformity with markers of abdominal lesions was developed. The odds ratio for spinal deformity was 5.7 (95% CI: 3.4-9.4) for each unit increase in adhesion score (0-6) and 4.9 (2.9-3.4) for each unit increase in melanin on abdominal organs (0-3). Lesions in the dorsal caudal part of the abdomen gave an odds ratio for spinal deformity of 2.2.
Higher-Dose Oxytocin and Hemorrhage After Vaginal Delivery (2012)

I.
STEPS 4.0: Fast and memory-efficient molecular simulations of neurons at the nanoscale (2022)

A bstract Recent advances in computational neuroscience have demonstrated the usefulness and importance of stochastic, spatial reaction-diffusion simulations. However, ever increasing model complexity renders traditional serial solvers, as well as naive parallel implementations, inadequate. This paper introduces a new generation of the STochastic Engine for Pathway Simulation (STEPS) project, denominated STEPS 4.0, and its core components which have been designed for improved scalability, performance, and memory efficiency. STEPS 4.0 aims to enable novel scientific studies of macroscopic systems such as whole cells while capturing their nanoscale details. This class of models is out of reach for serial solvers due to the vast quantity of computation in such detailed models, and also out of reach for naive parallel solvers due to the large memory footprint. Based on a distributed mesh solution, we introduce a new parallel stochastic reaction-diffusion solver and a deterministic membrane potential solver in STEPS 4.0. The distributed mesh, together with improved data layout and algorithm designs, significantly reduces the memory footprint of parallel simulations in STEPS 4.0. This enables massively parallel simulations on modern HPC clusters and overcomes the limitations of the previous parallel STEPS implementation. Current and future improvements to the solver are not sustainable without proper software engineering practices. For this reason, we also give an overview of how the STEPS codebase and the development environment have been updated to follow modern software development practices. We benchmark performance improvement and memory footprint on three published models with different complexities, from a simple spatial stochastic reaction-diffusion model, to a more complex one that is coupled to a deterministic membrane potential solver to simulate the calcium burst activity of a Purkinje neuron. Simulation results of these models suggest that the new solution dramatically reduces the per-core memory consumption by more than a factor of 30, while maintaining similar or better performance and scalability.
On the problem of constructing a modern, economic radiotelescope complex (1977)

Criteria for comparing and planning the technical and economic characteristics of large parabolic reflector antenna systems and other types used in radioastronomy and deep space communications are discussed. The experience gained in making and optimizing a series of highly efficient parabolic antennas in the USSR is reviewed. Several ways are indicated for further improving the complex characteristics of antennas similar to the original TNA-1500 64m radio telescope. The suggestions can be applied in planning the characteristics of radiotelescopes which are now being built, in particular, the TNA-8000 with a diameter of 128 m.
ChemInform Abstract: Synthesis of Octyl Ester of p‐Substituted DL‐2‐Phenylglycines. (1990)

Abstract Esterification of ten phenylglycines such as (I) with n‐octanol (II) produces the corresponding n‐octyl phenylglycinate hydrochlorides (III).
Development of a New Life Equation for Ball and Roller Bearings (2000)

&lt;div class="htmlview paragraph"&gt;The conventional rolling bearing life equation &lt;sup&gt;(&lt;span class="xref"&gt;1&lt;/span&gt;)&lt;/sup&gt;, which is based on the theory of Lundberg and Palmgren, has a problem in that it does not match the actual bearing life in all operating conditions. For instance, while the actual life of a bearing under clean lubrication is 20 times longer than the calculated life, actual life under contaminated lubrication is as low as one-tenth of the calculated life.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;To solve this problem, the following life equation (&lt;span class="xref"&gt;Eq. 1&lt;/span&gt;: Advanced Bearing Life Equation) was developed with the a&lt;sub&gt;NSK&lt;/sub&gt; life modification factor:&lt;/div&gt; &lt;div class="htmlview paragraph"&gt; &lt;div id="FD1" class="formula"&gt; &lt;div class="graphic-wrapper"&gt;&lt;img class="article-image equation block" src="2000-01-2601_fig0001.jpg" alt="No Caption Available"/&gt;&lt;/div&gt; &lt;/div&gt; &lt;/div&gt; &lt;div class="htmlview paragraph"&gt;The new a&lt;sub&gt;NSK&lt;/sub&gt; factor is based on data from bearing life aNSK tests involving over 450 roller bearings and over 550 ball bearings under a variety of operating conditions. The new life equation with the a&lt;sub&gt;NSK&lt;/sub&gt; factor showed a satisfactory fit between calculated life and actual life.&lt;/div&gt;
p22 Is a Critical Component of the Superoxide-generating NADH/NADPH Oxidase System and Regulates Angiotensin IIinduced Hypertrophy in Vascular Smooth Muscle Cells (1996)

Superoxide anion formation is vital to the microbicidal activity of phagocytes. Recently, however, there is accumulating evidence that it is also involved in cell growth in vascular smooth muscle cells (VSMCs). We have shown that the hypertrophic agent angiotensin II stimulates superoxide production by activating the membrane-bound NADH/NADPH oxidase and that inhibition of this oxidase attenuates vascular hypertrophy. However, the molecular identity of this oxidase in VSMCs is unknown. We have recently cloned the cytochrome b558 alpha-subunit, p22(phox) (one of the key electron transfer elements of the NADPH oxidase in phagocytes), from a rat VSMC cDNA library, but its role in VSMC oxidase activity remains unclarified. Here we report that the complete inhibition of p22(phox) mRNA expression by stable transfection of antisense p22(phox) cDNA into VSMCs results in a decrease in cytochrome b content, which is accompanied by a significant inhibition of angiotensin II-stimulated NADH/NADPH-dependent superoxide production, subsequent hydrogen peroxide production, and [3H]leucine incorporation. We provide the first evidence that p22(phox) is a critical component of superoxide-generating vascular NADH/NADPH oxidase and suggest a central role for this oxidase system in vascular hypertrophy.
Involvement of brain opiate receptors in the immune-suppressive effect of morphine. (1986)

We previously reported that a single systemic injection of a high dose of morphine (greater than or equal to 20 mg/kg) transiently suppresses splenic natural killer cell cytotoxicity in rats. The present study examined the possibility that the immune-suppressive effect of morphine is mediated by opiate receptors in the brain. Supporting this hypothesis, we found that morphine (20 or 40 micrograms) injected into the lateral ventricle suppressed natural killer cell activity to the same degree as a systemic dose higher by three orders of magnitude. This effect was blocked by an opiate antagonist, naltrexone. Natural killer cell activity was unaffected by systemic administration of N-methyl morphine, a morphine analogue that does not cross the blood-brain barrier. These data implicate opiate receptors in the brain in morphine-induced suppression of natural killer cell cytotoxicity.
Perception Centered Transparency Evaluation of Wave-Variable Based Bilateral Teleoperation (2018)

Wave-variable transformation is a means to maintain stability of haptic teleoperation in the presence of communication time delays. Its drawback is that it affects haptic perception of remote properties and thereby degrades transparency. This paper studies the effect of wave-variable transformation on human haptic perception. Based on a framework of haptic perception developed in previous work, we systematically investigated how the wave variable affects human perception of damping, mass and stiffness properties of an arbitrary linear environment. Both the original wave-variable approach and the generalized wave-variable approach are investigated. Results show how both approaches change human perception of all three mechanical properties of the environment, and how these changes vary with both excitation frequency and time delay. The generalized wave-variable approach on the whole outperforms the original in terms of rendering mass and stiffness, but not always for rendering damping. Results also show that human perception of the dynamics rendered by both approaches is similar to that of the original environment only when time delays are small. As the time delay increases, evaluating the mechanical properties can become very difficult for a human operator if the interaction with the environment is not static.
Correction to "improvement of low-frequency characteristics of piezoelectric speakers based on acoustic diaphragms" [Sep 12 2027-2035] (2012)

When this paper [1] was published, the source of funding was omitted. The source of funding is provided in the footnotes to this Erratum. The authors regret this error.
The Debate Over Stabilization Policy (2011)

This 1986 book examines some of the main issues that have characterized macroeconomics: the debate between 'monetarists' and 'Keynesians'; the response to demand shocks and supply shocks, by which the monetary authorities control aggregrate nominal income and the use and relevance of the money supply as a target; and the consumption function and the determinants of wealth. It shows that Keynesian stabilization policies succeeded in reducing instability due to demand shocks dramatically, but that no aggregrate demand policy can stabilize both price and employment simultaneously after a supply shock. However, by assigning an overall 'social cost' to (excess) unemployment and (initially) unexpected inflation, an optimism path can be derived. In looking at the consumption function and determinants of wealth the empirical evidence is shown to be most consistent with the life-cycle hypothesis. A concluding section is devoted to the impact on private and national society of the 'social security revolution'.
Supplementary Table 1 from A First-in-Class TWIST1 Inhibitor with Activity in Oncogene-Driven Lung Cancer (2023)

&lt;p&gt;Supplementary Table 1&lt;/p&gt;
Feasibility study of CO2 removal from pressurized flue gas in a fully fired combined cycle : the Sargas project (2005)

In this article a novel concept for CO2 removal from power plants is discussed from a systems perspective. The main advantage of the process is that the investment cost and the power penalty for ...
Hyporeactivity of Infection: Potential Limitation to Therapeutic Use of Interferon-Inducing Agents (1972)

Interferon inducers are generally most effective as antiviral agents when used prophylactically. One possible explanation for this is that animals develop a state of hyporeactivity during the course of a virus infection. Such a progressive loss of capacity to produce interferon was observed with a representative group of interferon-inducing agents (polyinosinic-cytidylic acid, Tilorone hydrochloride, New-castle disease virus, or a strain of encephalomyocarditis virus) during the course of a model picornavirus infection in mice.