gebhart/patrepeval huggingface dataset:
Quantitative optical coherence tomography angiography of vascular abnormalities in the living human eye (2015)

Retinal vascular diseases are important causes of vision loss. A detailed evaluation of the vascular abnormalities facilitates diagnosis and treatment in these diseases. Optical coherence tomography (OCT) angiography using the highly efficient split-spectrum amplitude decorrelation angiography algorithm offers an alternative to conventional dye-based retinal angiography. OCT angiography has several advantages, including 3D visualization of retinal and choroidal circulations (including the choriocapillaris) and avoidance of dye injection-related complications. Results from six illustrative cases are reported. In diabetic retinopathy, OCT angiography can detect neovascularization and quantify ischemia. In age-related macular degeneration, choroidal neovascularization can be observed without the obscuration of details caused by dye leakage in conventional angiography. Choriocapillaris dysfunction can be detected in the nonneovascular form of the disease, furthering our understanding of pathogenesis. In choroideremia, OCT's ability to show choroidal and retinal vascular dysfunction separately may be valuable in predicting progression and assessing treatment response. OCT angiography shows promise as a noninvasive alternative to dye-based angiography for highly detailed, in vivo, 3D, quantitative evaluation of retinal vascular abnormalities.
Lipid-Inspired Ionic Liquids Containing Long-Chain Appendages: Novel Class of Biomaterials with Attractive Properties and Applications (2012)

Lipid-inspired ionic liquids, first described by our group in a symposium in 2007, and more extensively in recent publications, are a class of ionic liquids that utilize structural features similar to those of natural lipids to allow the incorporation of long alkyl chains in ionic liquids while preserving low melting points. Such compounds are of interest as potential separation agents, because of their higher solubility of non-polar compounds relative to other ionic liquids, lubrication applications and as models for lipid membranes. In addition, ionic liquids of cations bearing two lipid-like aliphatic tails are shown to have values of T m that can be very low, and that can be tunable by the addition, deletion, or combination of dipolar modules and side-chain double bonds. Furthermore, ILs with multiple hydroxyl and thioether functional groups are readily prepared by the photoinitiated radical coupling of 1-thioglycerol and salts of imidazolium and quaternary ammonium cations bearing tethered allyl and/or vinyl groups. The results of this research indicate that the construction of functionalized ILs using the thiol-ene reaction offers considerable promise as an easy methods to create structurally elaborated IL ions.
Aortic Root Distortion and Aortic Insufficiency During Balloon Angioplasty of the Right Ventricular Outflow Tract Prior to Transcatheter Pulmonary Valve Replacement (2016)

AD/AI is relatively common on aortography during simultaneous RVOT balloon angioplasty. Lack of AI progression by echocardiography post-TPV implant suggests these may be benign findings in most cases. However, AD/AI should be carefully evaluated in certain anatomic subtypes with close RVOT/aortic alignments.
Vasoactivity of intraluminal and extraluminal agonists in perfused retinal arteries. (1994)

Pig retinal arteries exhibited asymmetry in their responses to adrenergic agonists and K+, with contractions significantly larger when the drug was applied to the intraluminal surface rather than the extraluminal surface. This asymmetry may reflect an important property of retinal vessels. Microperfusion systems of this type may prove valuable in developing a better understanding of control mechanisms in retinal circulations.
Abnormal behaviours relevant to neurodevelopmental disorders in Kirrel3-knockout mice (2018)

In the nervous system, Kirrel3 is involved in neuronal migration, axonal fasciculation, and synapse formation. Recently, genetic links have been reported between mutations in the KIRREL3 gene and increased risk of neurodevelopmental disorders, including autism spectrum disorder (ASD) and intellectual disability. To elucidate the causal relationship between KIRREL3 deficiency and behavioural abnormalities relevant to neurodevelopmental disorders, we generated global Kirrel3-knockout (Kirrel3<sup>-/-</sup>) mice and investigated the detailed behavioural phenotypes. In the three-chambered social approach test, Kirrel3<sup>-/-</sup> mice displayed a significant preference for a mouse over a non-social object but no significant preference for a stranger mouse over a familiar mouse. Ultrasonic communications, including pup-to-mother calls, male-female courtship vocalisation and resident responses to intruder, were significantly impaired in Kirrel3<sup>-/-</sup> mice. Significant increases in locomotor activity and repetitive rearing were also observed in Kirrel3<sup>-/-</sup> mice. Furthermore, the performance of Kirrel3<sup>-/-</sup> mice in the rotarod test was significantly better than that of wild-type mice. In the acoustic startle test, Kirrel3<sup>-/-</sup> mice were significantly hypersensitive to acoustic stimuli. Anxiety-related behaviours and spatial or fear memory acquisition were normal in Kirrel3<sup>-/-</sup> mice. These findings suggest that Kirrel3<sup>-/-</sup> mice exhibit autistic-like behaviours, including social and communicative deficits, repetitive behaviours, and sensory abnormalities, as well as hyperactivity.
[The results and prospects of using ultrasound in pathohistological practice]. (1991)

The results of the ultrasound use for the acceleration of histologic tissue processing are analyzed. Main mechanisms of the ultrasound effects on tissues as well as a method of the UTP-1 apparatus use for the acceleration of the paraffin embedding are presented. The simplicity of this method, saving the chemicals without a quality loss, a possibility of tissue processing through paraffin and celloidin as well as having histological slides 5-6 hours after cutting material allow one to recommend the above apparatus for the practical use.
Confined water in controlled pore glass CPG-10-120 studied by positron annihilation lifetime spectroscopy and differential scanning calorimetry (2015)

The solidification and melting of water confined in the controlled pore glass (CPG) with average pore size 12.6 nm has been studied by differential scanning calorimetry (DSC) and positron annihilation lifetime spectroscopy (PALS). The fully-filled sample of CPG by water as well as the samples of CPG with different content of water were used. The measurements show the presence of amorphous and crystalline phases of water in this type and size of pores, freezing point depression of a confined liquid and presence of certain transitions at lower temperatures, which could be detected only for cooling regime. The localization of confined water in the partially filled pores of CPG at room temperature was studied.
Synergistic EMG control of FES elbow extension after spinal cord injury (2004)

Individuals with a C5/C6 spinal cord injury (SCI) have paralyzed elbow extensors, yet retain weak to strong voluntary control of elbow flexion and some shoulder movements. They lack elbow extension, which is critical during activities of daily living. This research focuses on development of a synergistic controller employing remaining voluntary elbow flexor and shoulder electromyography (EMG) to control elbow extension with functional electrical stimulation (FES). We hypothesized that the remaining voluntary upper extremity muscles of a C5/C6 SCI subject produce repeatable, recognizable patterns of EMG indicative of the required triceps stimulation level. EMG from voluntary elbow flexor and shoulder muscles were used as inputs to train and test an artificial neural network (ANN) to output triceps stimulation level. A biomechanical model of the arm was used to estimate the triceps stimulation levels required for a particular subject and endpoint force goal. EMG was collected from SCI subjects while they generated isometric force vectors of varying magnitude and direction using the predicted triceps stimulation levels. Once trained, the network controller yielded low error and generalized.
Activation of Caspase-2 in Apoptosis (1997)

Members of the CED-3/interleukin-1β-converting enzyme (ICE) protease (caspase) family are synthesized as proforms, which are proteolytically cleaved and activated during apoptosis. We report here that caspase-2 (ICH-1/NEDD-2), a member of the ICE family, is activated during apoptosis by another ICE member, a caspase-3 (CPP32)-like protease(s). When cells are induced to undergo apoptosis, endogenous caspase-2 is first cleaved into three fragments of 32–33 kDa and 14 kDa, which are then further processed into 18- and 12-kDa active subunits. Up to 50 μm <i>N</i>-acetyl-Asp-Glu-Val-Asp-aldehyde (DEVD-CHO), a caspase-3-preferred peptide inhibitor, inhibits caspase-2 activation and DNA fragmentation <i>in vivo</i>, but does not prevent loss of mitochondrial function, while higher concentrations of DEVD-CHO (>50 μm) inhibit both. In comparison, although the activity of caspase-3 is very sensitive to the inhibition of DEVD-CHO (<50 nm), inhibition of caspase-3 activation as marked by processing of the proform requires more than 100 μmDEVD-CHO. Our results suggest that the first cleavage of caspase-2 is accomplished by a caspase-3-like activity, and other ICE-like proteases less sensitive to DEVD-CHO may be responsible for activation of caspase-3 and loss of mitochondrial function.
Integración de las ciencias y la tecnología como tendencia educativa (2020)

Libro texto completo de Encuentros Nacionales e Internacionales del Departamento de Ciencias Basicas e Ingenieria Num. 5 (2019)
Design of a 2.7-GHz linear OTA and a 250-MHz elliptic filter in bipolar transistor-array technology (1993)

The design of a tunable high-frequency fully differential bipolar operational transconductance amplifier (OTA) is presented. Techniques resulting in tunability and broadbanding are discussed, as are unavoidable tradeoffs resulting from the lack of a vertical pnp device. Using an 8-GHz bipolar transistor array process, the simulated -3-dB frequency of the OTA is over 2.7 GHz, the maximum linear input range is +or-2.5 V, and the power dissipation is 28 mW for a power supply of +or-5 V. The OTA can also operate at a +or-2.5 V. The design of a third-order elliptic OTA-C filter with cutoff frequency of 250 MHz and tuning range from 200 to 290 MHz is presented. Filter nonidealities are analyzed, and predistortion and compensation techniques, are discussed. Temperature variations from -30 to +100 degrees C and supply variations from +or-4.5 to +or-7.5 V change the cutoff frequency of the filter by less than 10%. The Q-factor can be electronically adjusted for all frequencies in the tuning range.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Grain boundary phase equilibrium in metallic systems (1991)

Progresses in the structural and chemical characterization of grain boundaries in metals are reported. We have developed a solid state method for fabrication of a variety of important grain boundaries. This method is based on a sequence of heavy deformation of single crystals followed by controlled recrystallization. The structure of complex grain boundaries such as the quasiperiodic 45{degree}(100) twist in pure aluminum or the periodic {Sigma}5(310) in aluminum-5%Mg alloy has been elucidated. We have found the structural unit (SU) model to be very powerful for the description of quasiperiodic interfaces. The applicability of the SU model to heterophase interfaces is verified for Si-Al interfaces. Further advances have been achieved in the understanding of the driving forces for grain boundary segregation including elastic and electronic effects. Chemical effects on grain boundary core structure are observed in the case of Al-Mg alloys and Sr doped Si.
Stable reversal of multidrug resistance in colon cancer cells by RNA interference targeting the MDR1 gene (2009)

Colon cancer is one of the most common cancers in the world. Overexpression of MDR1 mRNA and P-gp is associated with the classic multidrug resistance of colon cancer cells. In our previous study, we reported on the transient specific reversal of MDR1/P-gp-dependent multi-drug resistance by RNA interference (RNAi) in colon cancer cells. In this study, RNAi targeting the MDR1 gene stably reversed MDR1/P-gp-dependent multidrug resistance in colon cancer cells. The plasmid vectors pSilencer-#4029, encoding #4029 MDR1 siRNA, and pSilencer-#4123, encoding #4123 MDR1 siRNA, were constructed and then transfected into COLO 320DM, a colon cancer multidrug-resistant cell line. Clone cells were screened by G418 and identified by RT-PCR and Western blot analysis. Cellular viability was measured using the MTT assay. Cell cycle analysis and intracellular adriamycin accumulation were assessed by flow cytometry. MDR1 mRNA and P-gp expression in positive clone cells, those stably transfected with MDR1 siRNA, was inhibited. The IC50 values of the antitumor drugs were significantly decreased in the positive clones compared to the COLO 320DM parent cell line, and the PI/AI values of positive clones treated with antitumor drugs were significantly decreased compared to the parent cells. In addition, the intracellular adriamycin accumulation of positive clones treated with adriamycin was significantly increased compared with COLO 320DM. This demonstrates that the stable transfection of plasmid vectors encoding MDR1 siRNA can stably reverse the MDR1/P-gp-dependent multidrug resistance of colon cancer cells.
Optical Conductivity of Insulating Al-Based Alloys: Comparison of Quasiperiodic and Periodic Systems (1994)

We report on the optical conductivity of the structurally ordered icosahedral quasicrystal ${\mathrm{Al}}_{70}$${\mathrm{Pd}}_{20}$${\mathrm{Re}}_{10}$ and the crystal ${\mathrm{Al}}_{2}$Ru obtained from the reflectance measured over a wide frequency range. Our results show that both the crystal and the quasicrystal are semiconductors and have quite similar band structure. The major difference between the two materials arises from the localization of the electronic states deep inside the band gap of the quasicrystal in spite of the metallic carrier density. We speculate that the quasiperiodic symmetry favors carrier localization.
Electron-Deficient Triphenylene and Trinaphthylene Carboximides (2009)

A series of triphenylene and trinaphthylene carboximides were synthesized mainly through Diels-Alder reactions between the in situ generated radialenes and N-alkylmaleimides. High electron affinity was obtained due to the attachment of electron-withdrawing carboximide groups. These disklike molecules can assemble into one-dimensional columnar structures in solid state and their mesophase properties were characterized by DSC, POM, and X-ray diffraction. Long-range ordered columnar phase was observed, qualifying them as potential n-type semiconductors in electronic devices.
Targets for Radiation-Induced Cell Death: When DNA Damage Doesn't Kill (2001)

Chinese hamster ovary (CHO) K1 and radiosensitive CHO irs-20 cells were synchronized in S phase and labeled for 10 min with 5-[(125)I]-iodo-2'-deoxyuridine ((125)IdU). The cells were washed, incubated in fresh medium for 1 h for incorporation of the intracellular radionucleotides into DNA, and then frozen (-80 degrees C) for accumulation of (125)I decays. At intervals after freezing, when the cells had accumulated the desired number of decays, aliquots of the frozen cells were thawed and plated to determine survival. The survival curves for K1 and irs-20 cells were similar from 100% to 30% survival. At higher (125)I doses (more decays/cell), the survival of K1 cells continued to decline exponentially, but the survival of X-ray-sensitive irs-20 cells remained at approximately 30% even after the cells had accumulated 1265 decays/cell. The results contradict the notion that increased DNA damage inevitably causes increased cell death. To account for these findings, we propose a model that postulates the existence of a second radiation target. According to this model, radiation damage to DNA may be necessary to induce cell death, but DNA damage alone is not sufficient to kill cells. We infer from the survival response of irs-20 cells that damage to a second (non-DNA) structure is involved in cell death, and that this structure directly affects the repair of DNA and cell survival.
Treatment of Infective Hepatitis with Methionine (1945)

m:. MI C:AL J OU,RN%\L may be due to nutritional factors. The rarity of this complication would make it extremely difficult to decide this point. It has been stated (Cohen, 1944) that methionine undoubtedly has beneficial effects in " subacute necrosis " of the liver. The proof of this would again demand a large and well-controlled series of cases. In our limited experience methionine has been ineffective in patients who had already developed symptoms of hepatic failure. Summary Five gramrres of methionine has been administered daily by mouth to altemate cases in a series of 100 Service patients with infective hepatitis. A comparison of clinical and biochemical criteria has shown no significant effect on the severity or duration of the disease or on the incidence of relapses.
Investigations of the behaviour of microwave thermography antennas when coupled to layered tissue regions (1995)

Test structures providing realistic simulations of the layering of body tissues have been used to investigate the radiometric response to be expected from common skin-fat-muscle regions. The electric field distributions in these models have been measured by the nonresonant perturbation method at 3.25 GHz, the mid-frequency of the range used for the radiometric measurements. Investigations have been made of the response patterns of dielectric loaded rectangular TE/sub 10/-mode and cylindrical TE/sub ll/-mode radiometry antennas coupled to uniform media and models of layered tissue regions. Sucrose solutions of 30% to 50% concentration have been used for skin and muscle simulation. At 3 GHz sucrose solutions conveniently provide dielectric properties close to those of medium to high water content tissues. Sheets of thermo-compressed fabric-phenolic resin insulating material have been used for low permittivity fat layer simulation. These provide a relative permittivity of 3.7 and a loss factor of 0.24. Measurements have also been made using porcine skin-fat layers, with the electric field distribution being measured in sucrose solution below the fat. The field perturbers used are hollow glass spheres of about 2 mm diameter, and low permittivity dielectric sheets 1 to 2 mm thick. A linear heterodyne reflectometer is used to measure the amplitude and phase of the reflection coefficient produced by the presence of the perturber in the fields of the test structure.
Exposing scholarly information as Linked Open Data: RDFizing DSpace contents (2014)

Purpose – This paper aims to introduce a transformation engine which can be used to convert an existing institutional repository installation into a Linked Open Data repository. Design/methodology/approach – The authors describe how the data that exist in a DSpace repository can be semantically annotated to serve as a Semantic Web (meta)data repository. Findings – The authors present a non-intrusive, standards-compliant approach that can run alongside with current practices, while incorporating state-of-the art methodologies. Originality/value – Also, they propose a set of mappings between domain vocabularies that can be (re)used towards this goal, thus offering an approach that covers both the technical and semantic aspects of the procedure.
Design and Development of a Smartphone Application for Hypertension Management: An Intervention Mapping Approach (Preprint) (2022)

<sec> <title>BACKGROUND</title> Several research studies have demonstrated the potential of mobile health applications (apps) in supporting health management. However, the design and development process of these apps are rarely presented. </sec> <sec> <title>OBJECTIVE</title> We present the design and development of a smartphone-based lifestyle app integrating a wearable device for hypertension management. </sec> <sec> <title>METHODS</title> We used an intervention mapping approach for the development of theory- and evidence-based interventions for problem identification, problem-solving and mitigation strategies. This consisted of six fundamental steps of the intervention mapping approach: needs assessment, matrices, theoretical methods and practical strategies, program design, adoption and implementation plan, and evaluation plan. To design the contents of the intervention, we performed a literature review to determine the opinions and preferences of people with hypertension and implemented theoretical and practical strategies to support these needs in consultation with stakeholders and researchers. </sec> <sec> <title>RESULTS</title> Through the needs analysis, we identified that people with hypertension preferred having education, medication or treatment adherence, lifestyle modification, alcohol and smoking cessation and blood pressure monitoring support to manage their condition. Out of which, the authors utilized MoSCoW analysis to focus on four key elements, i.e., education, medication or treatment adherence, lifestyle modification and blood pressure support due to past experiences in developing interventions for hypertension, and its potential benefits in hypertension management. Theoretical models such as (i) the information, motivation, and behaviour skills (IMB) model, and (ii) the patient health engagement (PHE) model was implemented in the intervention development to ensure positive engagement and health behaviour. The app developed provides education to people with hypertension related to their condition, while utilizing wearable devices to promote lifestyle modification and blood pressure support. The app also contains rules and medication lists titrated by the clinician to ensure treatment adherence, with regular push notifications to prompt behavioural change. In addition, the app data can be reviewed by patients and clinicians as needed. </sec> <sec> <title>CONCLUSIONS</title> This is the first study describing the development of an app that integrates a wearable blood pressure device and provides lifestyle support and hypertension management. Our theory-driven intervention for self-management of hypertension is founded on the critical needs of people with hypertension to ensure treatment adherence and supports medication review and titration by clinicians. The intervention will be evaluated clinically in future studies to determine its effectiveness and usability. </sec>
Interferon Regulatory Factor Expression in Human Breast Cancer (2001)

Expression of IRF-1 and IRF-2 is altered in human breast cancer compared with normal adjacent tissue. The loss of IRF-1 expression is consistent with tumor suppressor loss and the development of IRF-2 expression with oncogenic activation. These data support the hypothesis that this pathway is involved in human breast oncogenesis, which warrants further investigation regarding prognostic and therapeutic implications.