gebhart/patrepeval huggingface dataset:
Production of tumor necrosis factor by rIFN-gamma-primed C3H/HeJ ( Lps d) macrophages requires the presence of lipid A-associated proteins. (1988)

Previous studies have shown that the activation of murine macrophages to a fully tumoricidal state requires that specific environmental signals be delivered to the macrophage in a step-wise manner: a "priming" signal first renders the macrophage stimulated, but not cytolytic. The addition of a second or "trigger" signal to the primed macrophage results in tumoricidal activity. One potent priming signal has been identified as IFN-gamma and one often used trigger signal for endotoxin-responsive (Lpsn) macrophages is LPS. In contrast to LPS-responsive macrophage, rIFN-gamma-primed C3H/HeJ (Lpsd) macrophages fail to become cytolytic in response to protein-free, phenol-water-extracted LPS preparations, but become tumoricidal when exposed in vitro to protein-rich butanol-extracted LPS or purified lipid A-associated proteins. Further characterization of the activation requirements of the C3H/HeJ macrophages revealed that for optimal elaboration of TNF in vitro, two signals were also required: rIFN-gamma and a second signal that contained LAP. C3H/HeJ macrophages macrophages primed with rIFN-gamma failed to produce TNF in response to any concentration of protein-free phenol-water extracted LPS, even when supernatants were concentrated before assaying for functional activity in a standard TNF L929 fibroblast assay. Although exposure of rIFN-gamma-primed C3H/HeJ macrophages to LAP resulted in a fully tumoricidal state equivalent to that exhibited by C3H/OuJ macrophages, the levels of TNF produced remained discrepant. Under identical conditions, C3H/OuJ macrophages produced approximately fivefold more TNF (11,776 U/ml) than C3H/HeJ macrophages (2,399 U/ml). This suggests that although C3H/HeJ macrophages can respond functionally in a "normal" manner given the correct signals, they remain quantitatively deficient in the production of certain proteins. In this system, the elaboration of TNF and macrophage-mediated tumor cell lysis were shown to be dissociable events. The tumor target used in these studies (P815) was shown to be resistant to as much as 40,000 U/ml of purified rTNF. In addition, C3H/OuJ macrophage cultures exposed to LPS only (which resulted in the production of high levels of TNF), failed to lyse these targets. Lastly, anti-mouse TNF antibody added to macrophage cultures had no effect on the induction of tumor cell lysis.
Transanal Endoscopic Microsurgery (TEM) for minimally invasive resection of rectal adenomas and „low-risk” carcinomas (uT1, G1 - 2) (2002)

Transanal endoscopic microsurgery (TEM) presents a minimally invasive procedure for local removal of large rectal adenomas (>/= 2 cm) and early, so called "low-risk" carcinomas (uT1, G1 - 2) in curative as well as of advanced tumors in palliative intent. Over a 6-year period 92 TEM excisions of rectal tumors were carried out including 91 patients with 56 adenomas, 35 carcinomas (9 pTis, 17 pT1, 5 pT2, 3 pT3, 1 Ca after snare diathermy) and one neurinoma. Two patients of the carcinoma group had to be reoperated by means of anterior resection due to false preoperative rectal ultrasound examination (2 x uT1--> pT2). 4 patients required palliative therapy on account of age or high morbidity. After a mean follow-up time of 23 months (adenomas 23 months, pT1 carcinoma 26 months and advanced tumors 38 months) we encountered a total of 7 complications, of which in 5 cases surgical reintervention was necessary (5,4 %). One 86-year-old patient with a pT2-carcinoma, who was unsuitable for low anterior resection due to a high morbidity risk, died from myocardial infarction after emergency reintervention caused by postoperative bleeding. To date, overall 9 recurrences occurred (9,8 %). In the specific target group of TEM (adenomas and pT1, G1-2 carcinomas) consisting of n = 83 cases, the overall recurrence rate was 7,2 %, of which 5,3 % were due to adenomas and 11,5 % due to carcinomas. After palliative excision 2 recurrences occurred. These results of transanal endoscopic microsurgery (TEM) indicate that this technique has a useful place in curative, as well as in palliative management of rectal tumors.
ChemInform Abstract: ADDITION REACTIONS OF ORGANOTIN COMPOUNDS WITH N,N′‐BIS(PENTAFLUOROPHENYL)SULFUR DIIMIDE (1979)

Abstract Das Schwefeldiimid (I) reagiert in Methylenchlorid mit den Zinnaminen (II) zu den kristallinen 1:1‐Verbindungen (III).
Clinical Characteristics of 53 Dogs with Doppler-Derived Evidence of Pulmonary Hypertension: 1992–1996 (1999)

Pulmonary hypertension occurs as a primary or secondary disorder of the pulmonary vasculature. Doppler echocardiography provides a noninvasive tool for the estimation of pulmonary arterial pressure when tricuspid regurgitation or pulmonic insufficiency is present. The cardiology database at Colorado State University was reviewed, and echocardiographic records from cases diagnosed with pulmonary hypertension were evaluated. Application of the modified Bernoulli equation to the maximal instantaneous velocity of a right-sided regurgitant jet provided evidence of pulmonary hypertension in 53 dogs over a 4-year period. Tricuspid regurgitant velocity > or = 2.8 m/second or pulmonic insufficiency velocity > or = 2.2 m/second was considered abnormal and indicative of pulmonary hypertension. Tricuspid regurgitant gradients in 51 dogs ranged from 32 to 145 mm Hg (mean, 63.0 mm Hg; median, 57.0 mm Hg; 25th-75th percentiles, 45.2-76.5 mm Hg). Pulmonic insufficiency gradients in 8 dogs ranged from 20 to 100 mm Hg (mean, 59.5 mm Hg; median, 61.5 mm Hg; 25th-75th percentiles, 32.0-84.5 mm Hg). Affected dogs ranged in age from 2 months to 16 years. Clinical signs were characteristic of cardiopulmonary disease, but a relatively high frequency of syncope was noted (12 of 53 dogs, 23%). Pulmonary hypertension was probably due to increased pulmonary vascular resistance in 23 dogs, pulmonary overcirculation in 2 dogs, and pulmonary venous hypertension in 23 dogs. Five dogs lacked a clinically recognizable cardiopulmonary cause of pulmonary vascular disease. Our results suggest that pulmonary hypertension can occur as a complication of commonly encountered cardiopulmonary diseases, and that Doppler echocardiography can facilitate recognition of this condition.
Selective guest retention in thermal guest-release process in sandwich-type inclusion crystal of cholic acid (2009)

Ternary inclusion crystals of cholic acid (CA) with two aromatic compounds, m-fluoroaniline (G1) and indene (G2), were investigated from a viewpoint of selective incorporation and release. Recrystallization of CA from an equimolar mixture of G1 and G2 gave the CA crystal in a 47 : 53 molar ratio of G1 to G2. This ternary crystal has a sandwich-type structure with a two-dimensional (2D) host cavity consisting of two non-equivalent sites, A and B. G1 tends to be included in the site A owing to hydrogen bonds, while G2 in the site B. This site affinity for each guest was confirmed in a bulk crystal as well as in a single crystal of the ternary compound. Thermogravimetric analysis revealed that the two guest molecules were released at two different temperature ranges of 50–100 °C and 100–120 °C. Heat treatment of the starting crystal at 90 °C for 10 min yielded the expected intermediate crystal, which had a bilayer structure with a one-dimensional (1D) cavity in a 60 : 40 molar ratio of G1 to G2. Moreover, irrespective of the guest ratios in the starting CA crystals, G1 was preferentially retained in the thermal guest-release process. Such preferential retention of G1 is attributable to the host–guest hydrogen bond between CA and G1 at the site A in the 2D cavity.
The Practice of Pathology in Canada: Decreasing Pathologist Supply and Uncertain Outcomes (2011)

There is a trend toward a decreasing supply of Canadian pathologists relative to that of cancer demands. This finding confirms an earlier population-based study showing a decreased supply relative to population and number of clinical physicians. It is uncertain whether this decreased supply is a result of appropriate application of new, efficient methods or whether health care has been rationed or adversely impacted. Outcome measures to monitor Canadian pathology practice quality are clearly needed.
Targeting Trypsin-Inflammation Axis for Pancreatitis Therapy in a Humanized Pancreatitis Model (2016)

Abstract : Acute pancreatitis especially due to alcohol and smoking goes onto chronic pancreatitis which, in turn, is a risk factor for pancreatic cancer. Because only a relatively small portion of patients with alcohol abuse and smoking develop pancreatitis, it is very likely that there are genetic underlying predisposing factors that have not been discovered that explain why certain individuals develop pancreatitis. A genetic defect in the trypsinogen gene (PRSS1 gene) causing hereditary pancreatitis is now well established. We developed a transgenic mouse using a Bacterial Artificial Chromosome harboring the full-length human PRSS1 with the key mutation of hereditary pancreatitis (PRSS1R122H). During the funding year we used this novel mouse model to determine whether PRSS1R122H predispose to pancreatitis. Our data so far indicates that mice expressing PRSS1R122H develop a more severe form of pancreatitis than wild type mice controls. We are working now in understanding the mechanisms underlying the observed effects.
Low-Dose Dopamine or Low-Dose Nesiritide in Acute Heart Failure With Renal Dysfunction (2013)

clinicaltrials.gov Identifier: NCT01132846.
High-concentration photovoltaic module design (1986)

Over the past 3 years, Black and Veatch has been leading a team in the ongoing design of a high-concentration, high-performance photovoltaic (PV) module for the Electric Power Research Institute (EPRI). The current design consists of a deep-drawn aluminized steel housing containing 48 cell packages in a 4-row by 12-column matrix. Each cell package includes an anodized aluminum secondary optical element, a 27.5% efficient Stanford University/EPRI 500X concentration point contact silicon PV cell, an alumina substrate, and a copper heat spreader. Developmental efforts underway for a comolded glass/polymer Fresnel lens parquet indicate the potential for a substantial decrease in molding time and, thereby, cost, in comparison to more conventional compression molding of acrylic lenses. Further development is necessary to achieve comparable optical performance of the lens. Current activities have included the development of PVOPTICS, a Monte Carlo computer code particularly suited to the module optical design. The module is projected to produce 287 watts at an efficiency of 22%. The module cost, at large production rates, is estimated to be $275 ($0.96 per watt).
Anwendungsaufsatz / Application Paper: Ein Regelverfahren zur aktiven Filterung in der Starkstromtechnik / A control method for active filtering in high-voltage technology (1982)

Article Anwendungsaufsatz / Application Paper: Ein Regelverfahren zur aktiven Filterung in der Starkstromtechnik / A control method for active filtering in high-voltage technology was published on December 1, 1982 in the journal at - Automatisierungstechnik (volume 30, issue 1-12).
Effects of Appendages and Small Currents on the Hydrodynamic Heave Damping of TLP Columns (1998)

A previous paper by the authors reported on the estimation of resonant heave (springing) damping of tension leg platforms (TLPs) and a method of scaling for full-scale prototypes. The present paper is a sequel to this work, and examines the effect of adding an appendage in the form of a disk to TLP columns, and the influence of a small uniform current. Model tests conducted on a cylinder + disk in heave show that the heave damping induced by the disk is linear with the amplitude of oscillation. The disk is found to increase the form drag coefficient twofold, in accordance with published results based on isolated edge theory. The effects of a small uniform current were also examined during the model tests. Results show an increase in heave damping ratio that is linear with the current velocity. In the presence of a disk, the damping induced by the current is doubled as well. Scaling laws are proposed in this paper that enable extrapolation of heave damping due to appendages and small currents to full scale. An example calculation shows that for a full-scale TLP column, the heave damping is increased by about 300 percent due to addition of the disk, and by 87 percent due to a small current. The combination of the disk and the current increases the heave damping of the column by a factor of six.
Defect and fluctuation effects at the incommensurate-commensurate phase transition in Rb2ZnCl4 (1984)

The influence of defects and thermal fluctuations on the incommensurate-commensurate transition in modulated ferroelectric structures is studied. It is shown that the deviations near Tc from the equilibrium Landau theory can be understood in terms of an intermediate defect-dominated phase which they describe with a model of random internal fields. Choosing Rb2ZnCl4 as an example for quantitative comparison the authors use NMR, dielectric and X-ray satellite broadening data to evaluate the internal fields, the variation of the soliton density and the defect pinning energies. The roughness of the discommensuration walls in Rb2ZnCl4 is also estimated.
Extracting Boolean isosurfaces from tetrahedral meshes (2006)

Surfaces separating the inside from the outside of most solid objects of interest are piecewise smooth: they can be decomposed into smooth surface patches meeting along smooth boundary curves called creases. Normal vectors are discontinuous across creases, and creases join at their ends forming corners. Rather than identifying sharp features in an isosurface with additional Hermite data or detecting large changes in surface normals (see [Ju et al. 2002] and references within), we consider the Constructive Solid Geometry (CSG) representation of surfaces as boundaries of regularized Boolean combinations of half spaces. But here each half space is defined by one piecewise linear implicit function inequality. The Boolean Isosurface Algorithm for tetrahedral meshes (TBIso) outlined in this sketch extends the classical isosurface algorithms for tetrahedral grids from smooth implicit surfaces to volumetric sampled CSG surfaces in such a way that the feature lines are identified and extracted as poly-line networks. These feature lines and corners can be preserved during subsequent smoothing and simplification.
High-Resolution Structure of the Diphtheria Toxin Repressor Complexed with Cobalt and Manganese Reveals an SH3-like Third Domain and Suggests a Possible Role of Phosphate as Co-corepressor, (1996)

The crystal structure of diphtheria toxin repressor (DtxR) in complex with the corepressor Co2+ has been determined at 2.0 A resolution and in complex with Mn2+ at 2.2 A resolution. The structure of the flexible third domain could be determined at this high resolution. It appears to contain five antiparallel strands exhibiting a fold very similar to the SH3 domain. A superposition of 46 equivalent C alpha atoms of DtxR and alpha-spectrin SH3 resulted in an rms deviation of 3.0 A. The sequence identity is only 7%. This third domain of DtxR appears to have no interactions with the DNA binding domain nor with the metal binding domain of the repressor. Yet, flexibility in the region between the second and the third domain allows in principle significant conformational changes such as might occur upon DNA binding. The two metal binding sites in the second domain have been unraveled in considerable detail. Metal binding site 1 was well occupied in both the cobalt and manganese structures and showed a surprising sulfate ion as ligand. The sulfate was proven beyond doubt by the high peak at its position in a selenate versus sulfate difference Fourier. The presence of the intriguing sulfate ion at such a crucial position near the metal corepressor suggests the possibility that under physiological conditions phosphate may act as a "co-corepressor" for this class of metal-regulated DNA binding proteins in Corynebacteria, Mycobacteria, and related organisms. The second metal binding site is significantly different in these two DtxR structures. In the 2.0 A cobalt structure, the site is not occupied by a metal ion. In the 2.2 A manganese structure the site is well occupied, at approximately the same position as observed previously in cadmium DtxR. The ligands are Glu105, His106, the carbonyl oxygen of Cys102, and a water molecule. The reasons for differential occupancy of this site in different structures are intriguing and require further investigations.
Operational Assessment for Screener Proficiency Evaluation and Reporting System (SPEARS) Threat Image Projection. (1996)

Abstract : This document is the Operational Assessment (QA) of the threat image projection training and testing component of the Screener Proficiency Evaluation and Reporting System (SPEARS) conducted at Los Angeles International Airport in 1995. This OA covers the test and evaluation of the EG&G Astrophysics Training and Testing (TnTTM) system which focused on determining its effectiveness in meeting the requirements set forth in the Critical Operational Issues and Criteria, Critical Technical Issues and Criteria and Test and Evaluation Plan provided by the Federal Aviation Administration. The TnTTM system did not meet 2 of the 3 Critical Operational Criteria and 4 of 7 Critical Technical Criteria during this test and should be considered ineffective and unsuitable in its current configuration.
Tongue Abnormalities on MRI Associated With Severity And Progression In ALS (P5.027) (2014)

Objective. The objective of the present study was to describe patients with definite amyotrophic lateral sclerosis (ALS) correlating their clinical phenotype, ALS severity and progression rate (PR) of the disorder with tongue abnormalities observed through MRI. Background. Tongue abnormalities by MRI in ALS have been described as a “one sign wonder” associated to the disease. Important information related to this event remains unknown. Methods. We described a retrospective study of 43 patients with definite ALS evaluated by MRI. Tongue shape, position and hyperintense signals were correlated with clinical phenotypes, PR (diagnosis to MRI) and ALS functional rating scales revised (ALSFRS-r). Unvariate comparisons among the clinical onset and the presence of tongue abnormalities were made with an independent t-test and X2. The PR and its association to tongue abnormalities were evaluated with a Mann-Whitney U-Test. For the analysis of clinical functionality we separate the groups depending on the presence or absence of abnormalities and compare both groups mean ALSFRS-r scores as well as a short-ALSFRS scores with a descriptive method. Statistical significance was tested at 5% level. Results. A normal tongue was observed in 44 % of patients (median PR 10 months) and abnormalities in 56 % (median PR 18 months) (p= 0071). Patients with normal tongue presented ALSFRS-r scores of 32.47 +/- 9.14. Patients presenting tongue abnormalities scored 29 +/- 6.01(p= 0.14). No significant differences were found when correlating tongue abnormalities with clinical phenotype (spinal or bulbar). Conclusions We conclude that tongue abnormalities on MRI were not related to the clinical phenotype; nevertheless an association exists between the abnormality, PR, and severity of ALS. Our results hint the possibility of associating this radiological sign with disease progression and aggressiveness.
Monitoring of atherosclerotic plaque progression in ApoE KO mice: - a comparison of in vivo 7T MRI and ex vivo microCT (2019)

Poster: ECR 2019 / C-2713 / Monitoring of atherosclerotic plaque progression in ApoE KO mice: - a comparison of in vivo 7T MRI and ex vivo microCT by: C. Jung , M. Heine, M. Kaul, F. Kording, G. Adam, H. Ittrich; Hamburg/DE
Equation of State of Water to 250 Kilobars (1957)

An equation of state for water, applicable in the pressure range 25 kilobars to 250 kilobars, is formulated in terms of experimental data obtained from shock wave measurements. This equation of state is used to calculate P-V relations for several adiabats and isotherms. Thermodynamic and hydrodynamic data along the Hugoniot curve are given as a function of shock pressure, and pressure-particle velocity relations for initial shocks followed by reflected shocks and rarefactions are given.
Development of the Thick - Film Capacitor and Its Application for Hybrid Circuit Modules (1979)

New dielectric pastes with high and low dielectric constants and an advanced passivation system have been developed for highly reliable capacitors and crossovers in thick-film circuit modules. Colloidal magnetite has been found to be a good sintering agent in BaTiO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> -based high-K dielectric paste, and a crystallized low-K glass paste has been found to be suitable for small capacitors and crossovers. Alloyed Ag/Pd and Ag/PdO have been developed for conducting electrodes, which are compatible with the dielectric materials and the firing process. Physical defects are the critical factors in the glass passivation systems for the reliability because of possible moisture diffusion into the dielectrics. A new two-layered passivation system has been adopted. The capacitor system has been applied to an RF/IF thick-film hybrid module for radio-cassette recorders.
La inmigración latinoamericana en Madrid: Geografías de la convivencia intercultural de los jóvenes (2012)

Esta comunicacion presenta algunos de los resultados de las investigaciones realizadas en el Grupo de Investigacion CEMIRA Centro de Estudios de Migraciones y Racismo y en el Departamento de Geografia Humana sobre la inmigracion latinoamericana en Madrid. Se presentan las cartografias actualizadas de la distribucion espacial de los inmigrantes en el municipio de Madrid y especialmente el analisis de las pautas de localizacion de los jovenes latinoamericanos, a nivel de seccion censal, barrio y distrito. Asimismo, se muestra una investigacion sobre la convivencia intercultural de la juventud madrilena (espanoles e inmigrantes), incluyendo un estudio pionero sobre percepciones y comportamientos, especialmente sobre el ocio de los jovenes. Se han identificado los elementos que interaccionan y componen el ocio de los jovenes latinoamericanos aportando una cartografia nueva de los espacios de mayor socializacion y convivencia cultural en Madrid.
Synthesis and Molecular Recognition Studies of the HNK-1 Trisaccharide and Related Oligosaccharides. The Specificity of Monoclonal Anti-HNK-1 Antibodies as Assessed by Surface Plasmon Resonance and STD NMR (2011)

The human natural killer cell carbohydrate, HNK-1, plays function-conducive roles in peripheral nerve regeneration and synaptic plasticity. It is also the target of autoantibodies in polyneuropathies. It is thus important to synthesize structurally related HNK-1 carbohydrates for optimizing its function-conducive roles, and for diagnosis and neutralization of autoantibodies in the fatal Guillain-Barré syndrome. As a first step toward these goals, we have synthesized several HNK-1 carbohydrate derivatives to assess the specificity of monoclonal HNK-1 antibodies from rodents: 2-aminoethyl glycosides of selectively O-sulfated trisaccharide corresponding to the HNK-1 antigen, its nonsulfated analogue, and modified structures containing 3-O-fucosyl or 6-O-sulfo substituents in the N-acetylglucosamine residues. These were converted, together with several related oligosaccharides, into biotin-tagged probes to analyze the precise carbohydrate specificity of two anti-HNK-1 antibodies by surface plasmon resonance that revealed a crucial role of the glucuronic acid in antibody binding. The contribution of the different oligosaccharide moieties in the interaction was shown by saturation transfer difference (STD) NMR of the complex consisting of the HNK-1 pentasaccharide and the HNK-1 412 antibody.