gebhart/patrepeval huggingface dataset:
Exploring the speed limits of liquid chromatography using shear-driven flows through 45 and 85 nm deep nano-channels (2013)

We explored the possibility to perform high speed and high efficiency liquid chromatographic separations in channels with a sub-100 nm depth. The mobile phase flow through these nano-channels was generated using the shear-driven flow principle to generate high speed flows which were the equivalent of a 12,000 bar pressure-driven flow. It was found that the ultra-fast mass transfer kinetics prevailing in this range of small channel depths allow to drastically reduce the C-term contribution to band broadening, at least up to the upper speed limit of our current set-up (7 mm s(-1) mobile phase velocity), leaving the inescapable molecular diffusion (i.e., B-term band broadening) as the sole detectable source of band broadening. Due to the greatly reduced mass transfer limitations, 50,000 to 100,000 theoretical plates could be generated in the span of 1 to 1.5 seconds. This is nearly two orders of magnitude faster than the best performing commercial pressure-driven UHPLC-systems. With the employed channel depths, we appear to have struck a practical lower limit for the channel miniaturization of shear-driven flows. Despite the use of channel substrates with the highest grades of optical flatness, the overall substrate waviness (on the order of some 5 to 10 nm) can no longer be neglected compared to the etched channel depth, which in turn significantly influenced the local retention factor and band broadening.
The Clinical Effectiveness of 6 mm Diameter Implants (2005)

This study showed that high survival rates can be obtained after prosthetic treatment with 6 mm-wide tapered HA-coated implants. Long-term prospective studies are needed to confirm these results.
The ‘dark’ side of sedation: 12 years of office‐based pediatric deep sedation for electroretinography in the dark (2010)

We demonstrated that pediatric sedation is a safe, efficient, and a cost-effective method for measuring ERGs in a challenging environment. The incidence of minor complications is low and appears similar to other studies of propofol sedation.
EEPROM programming study-time and degradation aspects (2002)

Electrically-erasable programmable read-only memory (EEPROM) reliability is of crucial interest. In a previous study of EEPROM cells programming we have shown that it is possible to decrease the electric field across the tunnel oxide with an appropriate programming signal without any change in the device. This improves the endurance of the memory cell with the same injected charge and the same performances. Another way to decrease the degradation of the oxide is to reduce the duration of the stress induced by the electric field across the tunnel oxide. Using the previous study, we show it is possible to reduce the programming time by a factor of ten compared to a standard signal.
Polymerase chain reaction detection of bacterial 16S rRNA gene in human blood (2008)

Bacterial 16S ribosomal RNA genes (rDNA) were detected in blood samples from two healthy individuals by PCR under conditions involving 30 cycles that did not produce any visible products from negative control saline. Even from control samples, PCR involving 35-40 cycles yielded visible bands. Major clones detected in the blood samples, but not in control, were the Aquabacterium subgroup, Stenotrophomonas subgroup, Budvicia subgroup, Serratia subgroup, Bacillus subgroup and Flavobacteria subgroup. No clone was located within the bacteroides-clostridium-lactobacillus cluster, which is indigenous to gastrointestinal flora.
Live-cell single-molecule labeling and analysis of myosin motors with quantum dots (2016)

Quantum dots (QDs) are a powerful tool for quantitatively analyzing dynamic cellular processes by single-particle tracking. However, tracking of intracellular molecules with QDs is limited by their inability to penetrate the plasma membrane and bind to specific molecules of interest. Although several techniques for overcoming these problems have been proposed, they are either complicated or inconvenient. To address this issue, in this study, we developed a simple, convenient, and nontoxic method for labeling intracellular molecules in cells using HaloTag technology and electroporation. We labeled intracellular myosin motors with this approach and tracked their movement within cells. By simultaneously imaging myosin movement and F-actin architecture, we observed that F-actin serves not only as a rail but also as a barrier for myosin movement. We analyzed the effect of insulin on the movement of several myosin motors, which have been suggested to regulate intracellular trafficking of the insulin-responsive glucose transporter GLUT4, but found no significant enhancement in myosin motor motility as a result of insulin treatment. Our approach expands the repertoire of proteins for which intracellular dynamics can be analyzed at the single-molecule level.
NEURAL: a self-organizing routing algorithm for ad hoc networks (2005)

This paper evaluates a self-organizing routing protocol for ad hoc network, called the neuron routing algorithm (NEURAL). NEURAL has been designed taking into account the learning and self-organizing abilities of the brain. More precisely, it was inspired by the synapses process between neurons, when a signal is propagated. Basically, the most significant characteristic of NEURAL is the uniform distribution of the information around the node's location based on the current changes in its neighborhood. Using a 2-hop acknowledgment mechanism, local information is monitored in order to be used for route selection method, classification procedures and learning algorithms.
Books on India and Central Asia - 1. L'Art Gréco-Bouddhique du Gandhāra. Tome II, second fascicule. Par A. Foucher. 11 × 7, 409 pp., 331 plates. Paris: Imprimerie Nationale, 1922. (1924)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
A Detail-Based Method for Linear Full Reference Image Quality Prediction (2017)

In this paper, a novel full Reference method is proposed for image quality assessment, using the combination of two separate metrics to measure the perceptually distinct impact of detail losses and of spurious details. To this purpose, the gradient of the impaired image is locally decomposed as a predicted version of the original gradient, plus a gradient residual. It is assumed that the detail attenuation identifies the detail loss, whereas the gradient residuals describe the spurious details. It turns out that the perceptual impact of detail losses is roughly linear with the loss of the positional Fisher information, while the perceptual impact of the spurious details is roughly proportional to a logarithmic measure of the signal to residual ratio. The affine combination of these two metrics forms a new index strongly correlated with the empirical differential mean opinion score (DMOS) for a significant class of image impairments, as verified for three independent popular databases. The method allowed alignment and merging of DMOS data coming from these different databases to a common DMOS scale by affine transformations. Unexpectedly, the DMOS scale setting is possible by the analysis of a single image affected by additive noise.
Hydrogenation of CO2 to Formate using a Simple, Recyclable, and Efficient Heterogeneous Catalyst (2019)

Today, one of the most imperative targets to realize the conversions of CO<sub>2</sub> in industry is the development of practically viable catalytic systems that demonstrate excellent activity, selectivity, and durability. Herein, a simple heterogeneous Ru(III) catalyst is prepared by immobilizing commercially available RuCl<sub>3</sub>· xH<sub>2</sub>O onto a bipyridine-functionalized covalent triazine framework, [bpy-CTF-RuCl<sub>3</sub>], for the first time. This novel catalyst efficiently hydrogenates CO<sub>2</sub> into formate with an unprecedented turnover frequency (38800 h<sup>-1</sup>) and selectivity. In addition, the catalyst excellently maintains its efficiency over successive runs and produces a maximum final formate concentration of ∼2.1 M in just 2.5 h with a conversion of 12% in regard to CO<sub>2</sub> feed. The apparent advantages of air stability, ease of handling, simplicity, the use of a readily available metal precursor, and the outstanding catalytic performance make [bpy-CTF-RuCl<sub>3</sub>] one of the possible candidates for realizing the large-scale production of formic acid/formate by CO<sub>2</sub> hydrogenation.
Degradation Mechanism Characterization and Remaining Life Prediction for NiCoCrAlY Coatings (2004)

The cyclic oxidation behaviors of two NiCoCrAlY coatings, which are PWA 286 and CT102 (GT33-like), were characterized using one-hour thermal cycles between ambient temperature and a peak temperature at either 1010°C or 1066°C. Weight change curves were generated as a function of thermal cycles. During cyclic oxidation testing, selected test specimens were removed and sectioned to characterize the coating degradation processes, such as oxidation attack, type and morphology of oxides, Al depletion, β-phase exhaustion, microstructural changes, and thermal fatigue crack formation. These experimental data were utilized in conjunction with a coating lifing model, called COATLIFE, to develop coating life diagrams that depicts the useful life of the coatings as a function of cycle time. Application of the COATLIFE approach and the coating life diagrams to predicting the remaining lives of GT33-like and PWA 286 coatings are demonstrated for turbine blades in land-based combustion gas turbines.
Narrow-band imaging endoscopy to assess mucosal angiogenesis in inflammatory bowel disease: A pilot study (2010)

NBI may allow in vivo imaging of intestinal angiogenesis in IBD patients.
SNA multiple-system networking (1992)

Systems Network Architecture (SNA) has evolved from an architecture that supported implementation of tree networks rooted in a System/370 to an architecture that supports multiple-system networks with capabilities such as alternate paths and parallel links. This paper describes the major SNA enhancements that have been implemented for multiple-system networks. As network configurations have become more complex, the problems associated with network growth, change, failures, recovery, and flow control have required solutions that permit continuous network operation. The SNA enhancements that address these problems are also discussed.
A case study of acenocoumarol sensitivity and genotype‐phenotype discordancy explained by combinations of polymorphisms in VKORC1 and CYP2C9 (2006)

To determine the cause of a genotype-phenotype discordancy for acenocoumarol sensitivity. Methods A patient, highly sensitive to acenocoumarol, and previously determined to carry only a single CYP2C9*3 allele, was genotyped for additional functionally defective alleles in the CYP2C9 and VKORC1 genes. Family members were also analyzed to trace the pedigree. Results The acenocoumarol-sensitive patient was found to possess, in addition to CYP2C9*3 allele, a CYP2C9*11 allele and the VKORC1 AA diplotype which were all traced back through the parental lines. Conclusions Acenocoumarol sensitivity in this subject is the consequence of inheritance of multiple functionally defective alleles in both the CYP2C9 and VKORC1 genes. The study provides additional data in support of diminished CYP2C9 activity due to the presence of the rare *11 allele.
Power-Efficient Transceivers for High-Bandwidth, Short-Reach Interconnects (2012)

Coming exa-scale computer systems and next-generation data centers impose extreme demands on transceiver technology to simultaneously achieve high bandwidth in a compact footprint for maximum bandwidth density while minimizing both cost and power.
Males Are Capable of Long-Distance Dispersal in a Social Bee (2022)

Pollinator conservation is aided by knowledge of dispersal behavior, which shapes gene flow and population structure. In many bees, dispersal is thought to be male-biased, and males’ movements may be critical to maintaining gene flow in disturbed and fragmented habitats. Yet male bee movements are challenging to track directly and male dispersal ability remains poorly understood in most species. Here, we combine field manipulations and models to assess male dispersal ability in a stingless bee ( Tetragonula carbonaria ). We placed colonies with virgin queens at varying distances apart (1–48 km), genotyped the males that gathered at mating aggregations outside each colony, and used pairwise sibship assignment to determine the distribution of likely brothers across aggregations. We then compared simulations of male dispersal to our observed distributions and found best-fit models when males dispersed an average of 2–3 km (&amp;gt;2-fold female flight ranges), and maximum of 20 km (30-fold female flight ranges). Our data supports the view that male bee dispersal can facilitate gene flow over long-distances, and thus play a key role in bee populations’ resilience to habitat loss and fragmentation. In addition, we show that the number of families contributing to male aggregations can be used to estimate local stingless bee colony densities, allowing population monitoring of these important tropical pollinators.
Oxidation of Marchantin A Trimethyl Ether and Related Aromatic Compounds with m-Chloroperbenzoic Acid (1998)

MarchantinA trimethyl ether was subjected to react with mchloroperbenzoic acid to yield hydroxylated derivatives as well as ring C degraded esters.This reaction was confirmed by application to catechol dimethyl ether and dihydroeugenol dimethyl ether.
Molecular characterization of vulnibactin biosynthesis in Vibrio vulnificus indicates the existence of an alternative siderophore (2014)

Vibrio vulnificus is a halophilic estuarine bacterium that causes fatal septicemia and necrotizing wound infections in humans. Virulent V. vulnificus isolates produce a catechol siderophore called vulnibactin, made up of one residue of 2, 3-dihydroxybenzoic acid (2, 3-DHBA) and two residues of salicylic acid (SA). Vulnibactin biosynthetic genes (VV2_0828 to VV2_0844) are clustered at one locus of chromosome 2, expression of which is significantly up-regulated in vivo. In the present study, we decipher the biosynthetic network of vulnibactin, focusing specifically on genes around SA and 2, 3-DHBA biosynthetic steps. Deletion mutant of isochorismate pyruvate lyase (VV2_0839) or 2, 3-dihydroxybenzoate-2, 3-dehydrogenase (VV2_0834) showed retarded growth under iron-limited conditions though the latter showed more significant growth defect than the former, suggesting a dominant role of 2, 3-DHBA in the vulnibactin biosynthesis. A double deletion mutant of VV2_0839 and VV2_0834 manifested additional growth defect under iron limitation. Though the growth defect of respective single deletion mutants could be restored by exogenous SA or 2, 3-DHBA, only 2, 3-DHBA could rescue the double mutant when supplied alone. However, double mutant could be rescued with SA only when hydrogen peroxide was supplied exogenously, suggesting a chemical conversion of SA to 2, 3-DHBA. Assembly of two SA and one 2, 3-DHBA into vulnibactin was mediated by two AMP ligase genes (VV2_0836 and VV2_0840). VV2_0836 deletion mutant showed more significant growth defect under iron limitation, suggesting its dominant function. In conclusion, using molecular genetic analytical tools, we confirm that vulnibactin is assembled of both 2, 3-DHBA and SA. However, conversion of SA to 2, 3-DHBA in presence of hydrogen peroxide and growth profile of AMP ligase mutants suggest a plausible existence of yet unidentified alternative siderophore that may be composed solely of 2, 3-DHBA.
ChemInform Abstract: Asymmetric Synthesis of Tropans by Rhodium‐Catalyzed [4 + 3] Cycloaddition. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Electronic-structure calculations by first-principles density-based embedding of explicitly correlated systems (1999)

A first-principles embedding theory that combines the salient features of density functional theory (DFT) and traditional quantum chemical methods is presented. The method involves constructing a DFT-based embedding potential and then using it as a one-electron operator within a very accurate ab initio calculation. We demonstrate how DFT calculations can be systematically improved via this procedure. The scheme is tested using two closed shell systems, a toy model Li2Mg2, and the experimentally well characterized CO/Cu(111) system. Our results are in good agreement with near full configuration interaction calculations in the former case and experimental adsorbate binding energies in the latter. This method provides the means to systematically include electron correlation in a local region of a condensed phase.
A genetic variant in the catechol-O-methyl transferase (COMT) gene is related to age-dependent differences in the therapeutic effect of calcium-channel blockers (2017)

Hypertension is the leading risk factor for cardiovascular disease and one of the major health concerns worldwide. Genetic factors impact both the risk for hypertension and the therapeutic effect of antihypertensive drugs. Sex- and age-specific variances in the prevalence of hypertension are partly induced by estrogen. We investigated 6 single nucleotide polymorphisms in genes encoding enzymes involved in estrogen metabolism in relation to sex- and age-specific differences in the systolic and diastolic blood pressure (SBP and DBP) outcome under the treatment of diuretics, calcium-channel blockers (CCBs), angiotensin-converting-enzyme inhibitors, and angiotensin-receptor blockers (ARBs).We included 5064 subjects (age: 40-82) from the population-based CoLaus cohort. Participants were genotyped for the catechol-O-methyltransferase gene (COMT) variants rs4680, rs737865, and rs165599; the uridine-diphospho-glucuronosyltransferase 1A gene family (UGT1A) variants rs2070959 and rs887829; and the aromatase gene (CYP19A1) variant rs10046. Binomial and linear regression analyses were performed correcting for age, sex, body mass index, smoking, diabetes, and antihypertensive therapy to test whether the variants in focus are significantly associated with BP.All investigated COMT variants were strongly associated with the effect of diuretics, CCBs, and ARBs on SBP or DBP (P < .05), showing an additive effect when occurring in combination. After Bonferroni correction the polymorphism rs4680 (ValMet) in COMT was significantly associated with lower SBP in participants treated with CCBs (P = .009) with an especially strong impact in elderly individuals (age ≥ 70) alone (Δ = -14.08 mm Hg, P = .0005).These results underline the important role of estrogens and catecholamines in hypertension and the importance of genotype dependent, age-related adjustments of calcium-channel blocker treatment.
Construction of a single quantum dot nanosensor with the capability of sensing methylcytosine sites for sensitive quantification of methyltransferase (2020)

CpG island methylation plays an important role in diverse biological processes including the regulation of imprinted genes, X chromosome inactivation, and tumor suppressor gene silencing in human cancer. Due to the dependence of DNA methylation on DNA methyltransferase (MTase) activity, DNA MTases have become the potential targets in anticancer therapy. Herein we demonstrate for the first time the construction of a single quantum dot (QD) nanosensor with the capability of sensing methylcytosine sites for sensitive quantification of M.SssI CpG methyltransferase (M.SssI MTase). We design a biotin-/phosphate-modified double-stranded DNA (dsDNA) substrate with a 5'-G-C-G-mC-3'/3'-mC-G-mC-G-5' site for sensing M.SssI MTase. In the presence of M.SssI MTase, the methylation-responsive sequence of the dsDNA substrate is methylated and cleaved by GlaI endonuclease, producing two dsDNA fragments with a free 3'-OH terminus. In the presence of terminal deoxynucleotidyl transferase (TdT), multiple Cy5-dATPs can be sequentially added to the free 3'-OH terminus of dsDNA fragments to obtain biotin-/multiple Cy5-labeled dsDNAs. The resultant biotin-/multiple Cy5-labeled dsDNAs can assemble on the surface of the streptavidin-coated QD to obtain a QD-dsDNA-Cy5 nanostructure in which the fluorescence resonance energy transfer (FRET) from the QD to Cy5 can occur. The emission of Cy5 can be simply quantified by single-molecule detection. By the integration of sensing methylcytosine sites and enzymatic polymerization, the sensitivity of this nanosensor has been significantly enhanced. This nanosensor can detect as low as 2.1 × 10-7 U μL-1 M.SssI MTase with good selectivity against other cytosine MTases, and it can be further applied for the screening of MTase inhibitors and complex biological sample analysis, holding great potential in clinical diagnosis and drug discovery.
Measurement of $\Lambda$ baryon polarization in $e^+e^-\rightarrow\Lambda\bar\Lambda$ at $\sqrt{s} = 3.773$ GeV (2021)

Using a data sample of $\psi(3770)$ events collected with the BESIII detector at BEPCII corresponding to an integrated luminosity of 2.9 fb$^{-1}$, we report a measurement of $\Lambda$ spin polarization in $e^+e^-\rightarrow\Lambda\bar\Lambda$ at $\sqrt{s} = 3.773$ GeV. The significance of polarization is found to be 2$\sigma$ including the systematic uncertainty, which implies a zero phase between the transition amplitudes of the $\Lambda\bar{\Lambda}$ helicity states. This phase can be interpreted in terms of psionic form factors, and is determined to be $\Delta\Phi^{\Psi}$ = $\Phi^{\Psi}_{E} - \Phi^{\Psi}_{M}$ = $(71^{+66}_{-46}$ $\pm$ 5)$^{\circ}$. Similarly, the ratio between the form factors is found to be $R^{\psi}$ = $|G^{\Psi}_{E}/G^{\Psi}_{M}|$ = $0.48^{+0.12}_{-0.07}$ $\pm$ 0.04. The first uncertainties are statistical and the second systematic.
3‐D velocity model building: Defining base of salt by inverting gravity data (1995)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 19953‐D velocity model building: Defining base of salt by inverting gravity dataAuthors: Manik TalwaniWalter P. KessingerManik TalwaniHouston Advanced Research Center & Rice University and Walter P. KessingerHouston Advanced Research Centerhttps://doi.org/10.1190/1.1887479 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1887479FiguresReferencesRelatedDetailsCited byMultiscale nonlinear inversion of gravity data for depth-to-basement estimation via coupled stochastic-deterministic optimizationAli Jamasb, Seyed-Hani Motavalli-Anbaran, Vahid Entezar-Saadat, and Hermann Zeyen29 September 2021 | GEOPHYSICS, Vol. 86, No. 6Base of salt inversion using triangular facetsLeon Foks* and Yaoguo Li5 August 2014 SEG Technical Program Expanded Abstracts 1995ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1995 Pages: 1566 publication data© 1995 Copyright © 1995 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 10 Feb 2005 CITATION INFORMATION Manik Talwani and Walter P. Kessinger, (1995), "3‐D velocity model building: Defining base of salt by inverting gravity data," SEG Technical Program Expanded Abstracts : 263-263. https://doi.org/10.1190/1.1887479 Plain-Language Summary PDF DownloadLoading ...