gebhart/patrepeval huggingface dataset:
On the Gain of Joint Processing of Pilot and Data Symbols in Stationary Rayleigh Fading Channels (2012)

In many typical mobile communication receivers, the channel is estimated based on pilot symbols to allow for a coherent detection and decoding in a separate processing step. Currently, much work is spent on receivers which break up this separation, e.g., by enhancing channel estimation based on reliability information on the data symbols. In this paper, we evaluate the possible gain of a joint processing of data and pilot symbols in comparison to the case of a separate processing in the context of stationary Rayleigh flat-fading channels. Therefore, we discuss the nature of the possible gain of a joint processing of pilot and data symbols. We show that the additional information that can be gained by a joint processing is captured in the temporal correlation of the channel estimation error of the solely pilot-based channel estimation, which is not retrieved by the channel decoder in case of separate processing. In addition, we derive a new lower bound on the achievable rate for joint processing of pilot and data symbols. Finally, the results are extended to multiple-input multiple-output channels.
Rapid prototyping of periodically poled lithium niobate (2004)

Laser micro-machining techniques are used to scribe topographic electrode structures onto the surface of lithium niobate wafers. These structures define the regions of domain inversion when fabricating periodically poled lithium niobate using conventional electric field poling methods.
Approach Matters: The Kinetics of Interfacial Inverse‐Electron Demand Diels–Alder Reactions (2017)

Rapid and quantitative click functionalization of surfaces remains an interesting challenge in surface chemistry. In this regard, inverse electron demand Diels-Alder (IEDDA) reactions represent a promising metal-free candidate. Herein, we reveal quantitative surface functionalization within 15 min. Furthermore, we report the comprehensive effects of substrate stereochemistry, surrounding microenvironment and substrate order on the reaction kinetics as obtained by surface-bound mass spectrometry (DART-HRMS).
Disc degeneration after disc herniation: are we accelerating the process? (2013)

Standard discectomy in first-time lumbar HNP may increase the risk of subsequent same-level lumbar disc degeneration compared with microdiscectomy as seen in one low-quality study. However, disc degeneration is likely a natural, temporal consequence following HNP, as demonstrated in a second low-quality study. The overall strength of evidence for the conclusions is very low.
Screen-space perceptual rendering of human skin (2009)

We propose a novel skin shader which translates the simulation of subsurface scattering from texture space to a screen-space diffusion approximation. It naturally scales well while maintaining a perceptually plausible result. This technique allows us to ensure real-time performance even when several characters may appear on screen at the same time. The visual realism of the resulting images is validated using a subjective psychophysical preference experiment. Our results show that, independent of distance and light position, the images rendered using our novel shader have as high visual realism as a previously developed physically-based shader.
Signal processing techniques for continuous monitoring of distortion product otoacoustic emissions in noisy industrial environments (2014)

Current progress in occupational health to prevent occupational noise-induced hearing loss (NIHL) is based on an average exposure/damage relationship.While this average is established on a group of exposed workers, individual susceptibility to NIHL is an important factor in a worker's actual risk of developing NIHL and is not accounted for at the moment.The measurement of otoacoustic emissions (OAE) is often considered a reliable tool to detect the onset of NIHL.Nevertheless, individual field measurement of OAEs on industrial workers is very challenging in practice because high ambient noise levels hinder proper OAE measurements.Use of OAE measurement probes with high passive noise isolation attenuates most of the high frequency ambient noise, but is often insufficient for the low frequency content.In previous research work by the authors, a new type of OAE system was designed to monitor OAE levels continuously on an individual worker.This new OAE system is capable of detecting a slight change in hearing sensitivity.The system features a pair of intra-aural hearing protectors (earplugs) which are equipped with an external microphone, an internal microphone and a pair of miniature receivers.Adaptive filtering on the OAE microphone signal is used to further improve the Signal-to-Noise ratio of the distortion product OAE (DPOAE) in frequencies where passive isolation remains insufficient.In this study, simulation and benchmarking of a further improved version of a DPOAE signal extraction algorithm designed for small digital signal processors (DSP), against other proven algorithms, shows a more stable performance across various DPOAE signal dynamic ranges and noise floor levels.
Application of Knowledge Management and e-Learning Integration Mechanism to Logistics Industry. (2004)

With the rapid growth of information technologies, our economic society and life are changing significantly in this digital age. The digital revolution in our world is spurring on facilities, hardware, software, services, and capital investment. In order to keep competitive advantage in the times of digital economy, more and more countries and enterprises pay more and more attention to the development and application of information technologies to help collect and diffuse the knowledge. This paper will investigate the application of the knowledge management and e-learning integration mechanism to logistics industries. The integration of knowledge management and e-learning is performed by building a virtual learning community. A virtual community can build an interactive learning environment for people. This helps the integration of knowledge management and e-learning. The concepts of developing and constructing virtual learning communities for logistics industries will be investigated in this study.
Composition phénolique et brunissement enzymatique. Etude en milieu modèle et application à différents extraits phénoliques de pomme (1993)

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Simple dichlorotris(triphenylphosphine)ruthenium-catalyzed synthesis of the 3,5,6,7-tetrahydro-4(2H)-benzofuranone system (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSimple dichlorotris(triphenylphosphine)ruthenium-catalyzed synthesis of the 3,5,6,7-tetrahydro-4(2H)-benzofuranone systemPnina Albin, Jochanan Blum, Esra Dunkelblum, and Yoel SassonCite this: J. Org. Chem. 1975, 40, 16, 2402–2403Publication Date (Print):August 1, 1975Publication History Published online1 May 2002Published inissue 1 August 1975https://pubs.acs.org/doi/10.1021/jo00904a031https://doi.org/10.1021/jo00904a031research-articleACS PublicationsRequest reuse permissionsArticle Views170Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Calcium Activates Nedd4 E3 Ubiquitin Ligases by Releasing the C2 Domain-mediated Auto-inhibition (2010)

Nedd4 E3 ligases are members of the HECT E3 ubiquitin ligase family and regulate ubiquitination-mediated protein degradation. In this report, we demonstrate that calcium releases the C2 domain-mediated auto-inhibition in both Nedd4-1 and Nedd4-2. Calcium disrupts binding of the C2 domain to the HECT domain. Consistent with this, calcium activates the E3 ubiquitin ligase activity of Nedd4. Elevation of intracellular calcium by ionomycin treatment, or activation of acetylcholine receptor or epidermal growth factor receptor by carbachol or epidermal growth factor stimulation induced activation of endogenous Nedd4 in vivo evaluated by assays of either Nedd4 E3 ligase activity or ubiquitination of Nedd4 substrate ENaC-beta. The activation effect of calcium on Nedd4 E3 ligase activity was dramatically enhanced by a membrane-rich fraction, suggesting that calcium-mediated membrane translocation through the C2 domain might be an activation mechanism of Nedd4 in vivo. Our studies have revealed an activation mechanism of Nedd4 E3 ubiquitin ligases and established a connection of intracellular calcium signaling to regulation of protein ubiquitination.
Analysis of the Proportional Hazards Model With Sparse Longitudinal Covariates (2020)

Regression analysis of censored failure observations via the proportional hazards model permits time-varying covariates which are observed at death times. In practice, such longitudinal covariates are typically sparse and only measured at infrequent and irregularly spaced follow-up times. Full likelihood analyses of joint models for longitudinal and survival data impose stringent modelling assumptions which are difficult to verify in practice and which are complicated both inferentially and computationally. In this article, a simple kernel weighted score function is proposed with minimal assumptions. Two scenarios are considered: half kernel estimation in which observation ceases at the time of the event and full kernel estimation for data where observation may continue after the event, as with recurrent events data. It is established that these estimators are consistent and asymptotically normal. However, they converge at rates which are slower than the parametric rates which may be achieved with fully observed covariates, with the full kernel method achieving an optimal convergence rate which is superior to that of the half kernel method. Simulation results demonstrate that the large sample approximations are adequate for practical use and may yield improved performance relative to last value carried forward approach and joint modelling method. The analysis of the data from a cardiac arrest study demonstrates the utility of the proposed methods.
Anesthetic drug development: Novel drugs and new approaches (2013)

The ideal sedative-hypnotic drug would be a rapidly titratable intravenous agent with a high therapeutic index and minimal side effects. The current efforts to develop such agents are primarily focused on modifying the structures of existing drugs to improve their pharmacodynamic and pharmacokinetic properties. Drugs currently under development using this rational design approach include analogues of midazolam, propofol, and etomidate, such as remimazolam, PF0713, and cyclopropyl methoxycarbonyl-etomidate (MOC-etomidate), respectively. An alternative approach involves the rapid screening of large libraries of molecules for activity in structural or phenotypic assays that approximate anesthetic and target receptor interactions. Such high-throughput screening offers the potential for identifying completely novel classes of drugs. Anesthetic drug development is experiencing a resurgence of interest because there are new demands on our clinical practice that can be met, at least in part, with better agents. The goal of this review is to provide the reader with a glimpse of the novel anesthetic drugs and new developmental approaches that lie on the horizon.
Aberrant SLC6A14 Expression Promotes Proliferation and Metastasis of Colorectal Cancer via Enhancing the JAK2/STAT3 Pathway (2021)

Our data illustrated the crucial function of SLC6A14 during CRC progression, suggesting SLC6A14/JAK2/STAT3 axis may serve as novel therapeutic targets for patients with CRC.
Down-Regulation of MMSET by RNA Interference Affects Cell Viability and Tumorigenicity in t(4;14) Myeloma Plasma Cells (2012)

Abstract Abstract 3998 The recurrent immunoglobulin translocation, t(4;14)(p16;q32) occurs in 15% of multiple myeloma patients and is the worst prognostic subgroup in MM, although the basis for this poor prognosis is unknown. The t(4;14) is unusual in that it involves 2 potential target genes: fibroblast growth factor receptor 3 (FGFR3) and multiple myeloma SET domain (MMSET). MMSET is universally overexpressed in t(4;14) MM, whereas FGFR3 expression is lost in one-third of cases. Nonetheless, The involvement of MMSET in the pathogenesis of t(4;14) multiple myeloma and the mechanism or genes deregulated by MMSET upregulation are still unclear. Here we demonstrate a role for MMSET in t(4;14) MM cells. We found that Down-regulation of MMSET expression in KMS11 cell by RNA interference and by selective disruption of the translocated MMSET allele using gene targeting dramatically reduced DNA synthesis in KMS11 decreased to 20% of that of the control, whereas the viability of cells decreased to 2% (p_ 0.01) of that of the control and increase in apoptosis was twice that of the control. These findings were associated with reduced expression of genes (e.g. CCND2, CCNG1, MAF and VEGF). These results provide direct evidence that MMSET plays a significant cell survival and antiapoptotic role in t(4;14) MM and suggest that therapies targeting this gene could impact this particular subset of poor-prognosis patients. Disclosures: No relevant conflicts of interest to declare.
Intestinal flora and human health. (1996)

There is a growing interest in intestinal flora and human health and disease. The intestines of humans contain 100 trillion viable bacteria. These live bacteria, which make up 30% of the faecal mass, are known as the intestinal flora. There are two kinds of bacteria in the intestinal flora, beneficial and harmful. In healthy subjects, they are well balanced and beneficial bacteria dominate. Beneficial bacteria play useful roles in the aspects of nutrition and prevention of disease. They produce essential nutrients such as vitamins and organic acids, which are absorbed from the intestines and utilised by the gut epithelium and by vital organs such as the liver. Organic acids also suppress the growth of pathogens in the intestines.Other intestinal bacteria produce substances that are harmful to the host, such as putrefactive products, toxins and carcinogenic substances. When harmful bacteria dominate in the intestines, essential nutrients are not produced and the level of harmful substances rises. These substances may not have an immediate detrimental effect on the host but they are thought to be contributing factors to ageing, promoting cancer, liver and kidney disease, hypertension and arteriosclerosis, and reduced immunity. Little is known regarding which intestinal bacteria are responsible for these effects. A number of factors can change the balance of intestinal flora in favour of harmful bacteria. These include peristalsis disorders, surgical operations of stomach or small intestine, liver or kidney diseases, pernicious anaemia, cancer, radiation or antibiotic therapies, immune disorders, emotional stress, poor diet and ageing. However, more importantly, the normal balance of intestinal flora may be maintained, or restored to a normal from an unbalanced state, by oral bacterio-therapy or by a well balanced diet. Oral bacterio-therapy using intestinal strains of lactic acid bacteria, such as lactobacillus and bifidobacteria, can restore normal intestinal balance and produce beneficial effects. Benefits include suppression of intestinal putrification so as to reduce constipation and other geriatric diseases; prevention and treatment of diarrhoea including antibiotic-associated diarrhoea; stimulation of the immune system; and increased resistance to infection.
Whole Genome Sequencing of Field Isolates Reveals Extensive Genetic Diversity in Plasmodium vivax from Colombia (2015)

Plasmodium vivax is the most prevalent malarial species in South America and exerts a substantial burden on the populations it affects. The control and eventual elimination of P. vivax are global health priorities. Genomic research contributes to this objective by improving our understanding of the biology of P. vivax and through the development of new genetic markers that can be used to monitor efforts to reduce malaria transmission. Here we analyze whole-genome data from eight field samples from a region in Cordóba, Colombia where malaria is endemic. We find considerable genetic diversity within this population, a result that contrasts with earlier studies suggesting that P. vivax had limited diversity in the Americas. We also identify a selective sweep around a substitution known to confer resistance to sulphadoxine-pyrimethamine (SP). This is the first observation of a selective sweep for SP resistance in this species. These results indicate that P. vivax has been exposed to SP pressure even when the drug is not in use as a first line treatment for patients afflicted by this parasite. We identify multiple non-synonymous substitutions in three other genes known to be involved with drug resistance in Plasmodium species. Finally, we found extensive microsatellite polymorphisms. Using this information we developed 18 polymorphic and easy to score microsatellite loci that can be used in epidemiological investigations in South America.
Estudio epidemiológico de un hato bovino con prevalencia media de brucelosis, vacunado con las mutantes rugosas de Brucella abortus RB51 y rfbK (2007)

Con el objetivo de analizar el comportamiento de dos vacunas rugosas de Brucella abortus, se trabajó en un hato bovino con prevalencia de brucelosis de 8.7%; se formaron al azar tres grupos: 392 vacas inmunizadas con RB51, 237 vacunadas con rfbK y 35 sin vacunar. Se realizaron estudios serológicos y bacteriológicos durante un año y se aplicó un estudio epidemiológico experimental comparativo longitudinal y prospectivo. En los tres grupos se presentaron abortos y mortinatos, de la leche de dos vacas del grupo testigo se aisló B. abortus biotipo 1. Bajo el criterio de que las vacas inmunizadas con cepas rugosas, positivas a la prueba de tarjeta, estaban infectadas, la tasa de incidencia mensual para las vacas vacunadas con RB51 fue de 1.65 por cada 100 vacas inmunizadas. Para las vacas que fueron inmunizadas con rfbK este valor fue de 2.7, por lo que se registró una diferencia signifi cativa entre grupos (P 0.001). Si se analizan los resultados utilizando el criterio de que los animales que presentan títulos iguales o mayores a 1:100 permanecen como reactores, y los que tienen títulos de 1:50 o menores presentan una respuesta transitoria tornándose luego en negativos, la tasa de incidencia mensual para las vacas vacunadas con RB51 fue de 0.21 por cada 100 vacas inmunizadas. Para las vacas que fueron inmunizadas con rfbK este valor fue de 0.35, sin diferencia signifi cativa entre grupos (P 0.01). Se concluye que en hatos de mediana prevalencia de brucelosis, la presencia de reactores posvacunales se debe a una respuesta de tipo secundario por contacto con cepas de campo de B abortus, que no necesariamente indica infección y puede discernirse usando la prueba de Rivanol; bajo este criterio, la inmunización de vacas con cualquiera de las dos vacunas rugosas constituye un factor de protección.
Representation of Data Structures Using the Entity Relationship Model and the Transformation in Relational Databases (1996)

This paper is dedicated to support data modelling in the ESPRIT project CAPISCE (Computer Architecture for Production Information Systems in a Competitive Environment). The CAPISCE project aims at developing a system architecture and information tools to support and integrate company operations at strategic, tactical and operational levels in the process industries. A main task in this project is the development of general purpose data structures for the architecture mentioned above. This paper should help to get a common understanding on data modelling methods to use for the practical work. It describes how to use the method Entity Relationship Model (ERM), gives comments on special modelling questions and describes how data structures can be transformed into a relational data base using the SQL language. (orig.)
On Behavior of Strains of Strip in Forming a Flexible Channel Section (2012)

Products formed using a conventional cold-roll forming machine have cross-sectional profiles constrained to a single width along the longitudinal axis. Products with cross-sectional profiles varying in width in the longitudinal direction, namely, flexible cross sections, cannot be formed using a conventional cold-roll forming machine. In recent years, research and development of a flexible cold roll forming machine controlled by a Progressive Logic Controller (PLC) Unit to form products with flexible cross sections has been carried out in Japan and Europe. In 2011, we presented a forming method for several flexible channel sections and shape defects such as swell distortion, and edge buckling occurred during forming with this machine. In this study, the deformation process of strips in forming a flexible channel section with different widths using a four tandem flexible cold roll forming machine has been experimentally investigated from the relationship between the shape of blank sheets and the strain produced during passage through rolls. A flexible channel section is formed from a blank steel sheet of 0.5 mm thickness with the flexible edge lines. Moreover, the distribution of membrane strains and principal strains occurring at the flange and the web part during the forming of the flexible product are measured using a strain gauge. From these measurements, the mechanism of the occurrence of the swell distortion is clarified.
Data from A Genome-Wide Screen in <b><i>Saccharomyces cerevisiae</i></b> Reveals Altered Transport As a Mechanism of Resistance to the Anticancer Drug Bleomycin (2023)

&lt;div&gt;Abstract&lt;p&gt;The potent DNA damaging agent bleomycin (BLM) is highly effective for treating various cancers, although, in certain individuals, the development of cellular resistance to the drug can severely diminish its antineoplastic properties. We performed two independent genome-wide screens using a &lt;i&gt;Saccharomyces cerevisiae&lt;/i&gt; mutant collection to isolate variants exhibiting either sensitivity or resistance to BLM. This procedure reproducibly identified a relatively large collection of 231 BLM-hypersensitive mutants, representing genes belonging to diverse functional groups. In contrast, only five BLM-resistant mutants could be recovered by our screens. Among these latter mutants, three were deleted for genes involved in plasma membrane transport, including the l-carnitine transporter Agp2, as well as the kinases Ptk2 and Sky1, which are involved in regulating polyamine transport. We further showed that Agp2 acts as a transporter of BLM and that overexpression of this transporter significantly enhances BLM-induced cell killing. Our data strongly implicate membrane transport as a key determinant in BLM resistance in yeast. This finding is critical, given that very little is known about BLM transport in human cells. Indeed, characterization of analogous mechanisms in humans may ultimately lead to enhancement of the antitumor properties of BLM.&lt;/p&gt;&lt;/div&gt;
Nonlinear Properties of Silicon Optical Fibers (2012)

The nonlinear transmission properties of hydrogenated amorphous silicon core fibers are characterized for short pulse propagation. Simple pump-probe experiments are employed to demonstrate their use for all-optical control via phase and amplitude modulation.