gebhart/patrepeval huggingface dataset:
Dérivés hétérocycliques de la classe des pyrimidobenzimidazoles I (1950)

Abstract The authors describe a serie of pyrimido‐[1.2‐ a ]‐benzimidazoles and related compounds obtained by the condensation of 2‐aminobenzimidazole, 4–5‐diphenyl‐2‐aminoimidazole and 2‐aminoimidazoline with β‐ketonic esters, malonic esters, and β‐imino‐nitriles.
Medical applications of NMR imaging and NMR spectroscopy with stable isotopes. Summary (1983)

The current status of NMR imaging and NMR spectroscopy are summarized. For the most part examples from the March 1983 Puerto Rico symposium are used to illustrate the utility of NMR in medicine. 18 refs., 5 figs.
Single-Frequency Cr:ZnSe Laser (2004)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text G. J. Wagner, B. G. Tiemann, W. J. Alford, and T. J. Carrig, "Single-Frequency Cr:ZnSe Laser," in Advanced Solid-State Photonics, OSA Technical Digest (Optica Publishing Group, 2004), paper WB12. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Short-Course Regimens of Artesunate-Fosmidomycin in Treatment of Uncomplicated Plasmodium falciparum Malaria (2005)

Fosmidomycin is effective against malaria, but it needs to be given for > or =4 days when used alone. We conducted a study of 50 children with Plasmodium falciparum malaria to evaluate the safety and efficacy of consecutively shortened regimens of artesunate-fosmidomycin (1 to 2 mg/kg of body weight and 30 mg/kg of body weight, respectively; doses given every 12 hours). All dosing regimens were well tolerated. Artesunate-fosmidomycin acted rapidly, resulting in consolidated geometric mean parasite and fever clearance times of 24 h and 15 h, respectively. Treatment regimens of > or =2 days led to cure ratios of 100% by day 14 (39/39; 95% confidence interval [95% CI], 91% to 100%). Most importantly, the 3-day regimen achieved 100% cure on day 28 (10/10; 95% CI, 69% to 100%). Treatment with artesunate-fosmidomycin was associated with transient grade I or II neutropenia (absolute neutrophil counts of 750 to 1,200/microl and 400 to 749/microl, respectively) in six or two patients, respectively. Artesunate-fosmidomycin demonstrates the feasibility and potential value of short-course artemisinin-based combination chemotherapy with rapidly eliminated combination partners.
MCM2 and Ki-67 Expression in Human Lung Adenocarcinoma: Prognostic Implications (2004)

High LIs of MCM2 and/or Ki-67 suggest a poor prognosis in patients with lung adenocarcinoma (non-pure bronchioloalveolar carcinoma).
Targeted delivery of CuS nanoparticles through ultrasound image-guided microbubble destruction for efficient photothermal therapy (2013)

Novel "soft" microbubbles have been fabricated to show outstanding ultrasound imaging capability, and triggered CuS nanoparticles delivery through ultrasound-targeted microbubble destruction for efficient photothermal ablation of cancer cells.
Integrated Application of CBT, TDT and TBL in Marketing Teaching —Take “Classic Case Analysis” as an Example (2020)

三仓出版社主要从事中文国际开源期刊的出版与发行，期刊领域涵盖工程技术、数学与物理、人文社会、信息科学、经济与管理、医药卫生、农业、地球环境等学科，借助互联网思维及现代信息技术，立足国内高校及研究机构的科研需求，力图推动中国学术界知识的交流与传播，可期刊发表、发表论文、快速发表，见刊快。三仓出版社欢迎广大科研学者加入我们，参与审稿，合作办刊，投稿荐稿，与中文期刊一同成长壮大。如果您对期刊有任何的意见或者建议，请联系service@sciscanpub.com.
Competing ring cleavages in substituted 4‐arylcyclohexanols and their methyl ethers under electron impact (1978)

Abstract Ring cleavage α to the oxygen function leads to [C 3 H 5 O] + and [C 4 H 7 O] + ions in the mass spectra of 4‐arylcyclohexanols and their methyl ethers, respectively. Cleavage α to the aryl group gives rise to [C 3 H 7 O] + (from the alcohols), [C 4 H 9 O] + (from the ethers) and [ArC 3 H 4 ] + (from both) ions. The competition between the two ring cleavages explains the effect of the substituents of the aryl groups on the relative abundances of the resulting ions.
Angiotensin-Converting Enzyme Inhibitor or Angiotensin II Type 1 Receptor Antagonist Therapy Is Associated with Prolonged Patient and Graft Survival after Renal Transplantation (2006)

Angiotensin-converting enzyme inhibitors (ACEI) or angiotensin II type 1 receptor blockers (ARB) reduce cardiovascular death in the general population, but data for renal transplant recipients remain elusive. Similarly, ACEI/ARB have been shown to reduce proteinuria, but data on graft survival are lacking. Therefore a retrospective open cohort study was conducted of 2031 patients who received their first renal allograft at the Medical University of Vienna between 1990 and 2003 and survived at least 3 mo. Patient and graft survival was compared between patients with versus without ACEI and/or ARB therapy. Data were analyzed with and without propensity score models for ACEI/ARB therapy. Medication and comorbidities were analyzed as time-dependent variables in the Cox regression analyses. Ten-year survival rates were 74% in the ACEI/ARB group but only 53% in the noACEI/ARB group (P < 0.001). The hazard ratio (HR) of ACEI/ARB use for mortality was 0.57 (95% confidence interval [CI] 0.40 to 0.81) compared with nonuse. Ten-year actual graft survival rate was 59% in ACEI/ARB patients but only 41% in nonusers (P = 0.002). The HR of actual graft failure for ACEI/ARB recipients was 0.55 (95% CI 0.43 to 0.70) compared with nonusers; the HR of functional graft survival was 0.56 (95% CI 0.40 to 0.78). Ten-year unadjusted functional graft survival rates were 76% among ACEI/ARB patients and 71% in noACEI/ARB recipients (P = 0.57). In summary, the use of ACEI/ARB therapy was associated with longer patient and graft survival after renal transplantation. More frequent use of these medications may reduce the high incidence of death and renal allograft failure in these patients.
A fundamental dispute: A discussion of “On some fundamentals of igneous petrology” by Bruce D. Marsh, Contributions to Mineralogy and Petrology (2013) 166: 665–690 (2015)

Marsh (Contrib Miner Petrol 166:665–690, 2013) again claims that crystal-free basalt magmas are unable to differentiate in crustal magma chambers and regards layered intrusions as primarily due to the repeated emplacement of crystal suspensions. He ignores an earlier critique of his unconventional inferences (Latypov, J Petrol 50:1047–1069, 2009) as well as a wealth of petrographic, geochemical and experimental evidence supporting the dominant role of fractional crystallization in the solidification of layered intrusions. Most tellingly, the cryptic variations preserved in the Skaergaard and many other basaltic layered intrusions would require an exceedingly implausible sequence of phenocrystic magmas but are wholly consistent with in situ fractional crystallization. A major flaw in Marsh’s hypothesis is that it dismisses progressive fractional crystallization within any magma chamber and hence prohibits the formation of crystal slurries with phenocrysts and melts that change systematically in composition in any feeder system. This inherent attribute of the hypothesis excludes the formation of layered intrusions anywhere.
Electronic structure of low-spin ferric porphyrins: a single-crystal EPR and structural investigation of the influence of axial ligand orientation and the effects of pseudo-Jahn-Teller distortion (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectronic structure of low-spin ferric porphyrins: a single-crystal EPR and structural investigation of the influence of axial ligand orientation and the effects of pseudo-Jahn-Teller distortionRobert Quinn, Joan Selverstone Valentine, Marianne P. Byrn, and Charles E. StrouseCite this: J. Am. Chem. Soc. 1987, 109, 11, 3301–3308Publication Date (Print):May 1, 1987Publication History Published online1 May 2002Published inissue 1 May 1987https://doi.org/10.1021/ja00245a019RIGHTS & PERMISSIONSArticle Views295Altmetric-Citations70LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (947 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Brief Announcement: Partial Reversal Acyclicity (2011)

Partial Reversal (PR) is a link reversal algorithm which ensures that an initially directed acyclic graph (DAG) is eventually a destination-oriented DAG. While proofs exist to establish the acyclicity property of PR, they rely on assigning labels to either the nodes or the edges in the graph. In this work we show that such labeling is not necessary and outline a simpler direct proof of the acyclicity property.
ChemInform Abstract: Circular Dichroism of Chromium(III) Complexes. Part ll. Chiroptical Evidence for Solution Structure of a Sexidentate Chelate Coordination Mode in Chromium(lII) Complexes with EDTA and Related Ligands. (1986)

Abstract The chiroptical spectra, specifically CD, of the chiral EDTA‐like complexes Na[CrL′] and Cr(HL′)(H2O) (H4L′: (S)‐1,2‐propylenediaminetetraacetate and (1 S,2S)‐ l ,2‐trans‐cyclohexanediaminetetraacetate) and MCD of the corresponding racemates were measured in solutions of various acid concentrations and/or solid states and compared with those of the CrL2(H2O) complexes (H3L2: (S)‐1,2‐propylenediaminetriacetate and (1S,2S)‐ 1 ,2‐trans‐cyclohexanediaminetriacetate).
Comparative Metabolism of Drugs in Man and Monkeys (1974)

The species occurrence among a few primate species including man of some metabolic reactions of importance in drug metabolism is surveyed. Many metabolic pathways are widespread in their species occurrence, and occur in man and other primate and nonprimate species. Some metabolic pathways, however, are more highly developed in primates or are in some cases restricted to primates or certain groups among them. Thus, the formation of the V-glucuronide of sulphadimethoxine and the O-methylation of 3,5-diiodo-4-hydroxybenzoic acid appear to be metabolic reactions largely restricted in their occurrence to man and other primates. The glutamine conjugation of phenylacetic and indoleacetic acids shows a remarkable correlation with evolutionary status since it appears to occur only in man, apes, New and Old World monkey species but not in prosimians and nonprimate species.
SAW devices on diamond (2002)

SAW characteristics in a ZnO/diamond/Si structure were investigated by theoretical calculations and experiments using poly-crystalline diamond films. It was found that the 1st mode in the ZnO/IDT/diamond/Si structure has the velocity of 10,500 m/s and K/sup 2/ value of 1.5%, and the 2nd mode in the IDT/ZnO/diamond/Si structure has the velocity of 11,600 m/s and K/sup 2/ value of 1.1%. The experimental results agreed well with the calculated data. Utilizing this high velocity, a 2.5 GHz filter was fabricated with 1 /spl mu/m line-and-space IDTs with the ZnO/IDT/diamond/Si structure. Propagation loss was confirmed to be much lower than ever reported for a ZnO/glass structure. It was also found by calculations that a SiO/sub 2//ZnO/diamond/Si structure realizes a zero TCD value with the velocity of 10,700 m/s and the K/sup 2/ value of 0.78% and that a LiNbO/sub 3//diamond/Si structure has a high velocity of 12,000 m/s and a large K/sup 2/ value of 9%. These structures including a diamond layer can be effectively used for a variety of applications in GHz range with much higher velocities than those of conventional SAW materials such as LiTaO/sub 3/, LiNbO/sub 3/ or quartz.
CFD Computations for a Generic High-Lift Configuration Using TetrUSS (2011)

Assessment of the accuracy of computational results for a generic high-lift trapezoidal wing with a single slotted flap and slat is presented. The paper is closely aligned with the focus of the 1st AIAA CFD High Lift Prediction Workshop (HiLiftPW-1) which was to assess the accuracy of CFD methods for multi-element high-lift configurations. The unstructured grid Reynolds-Averaged Navier-Stokes solver TetrUSS/USM3D is used for the computational results. USM3D results are obtained assuming fully turbulent flow using the Spalart-Allmaras (SA) and Shear Stress Transport (SST) turbulence models. Computed solutions have been obtained at seven different angles-of-attack ranging from 6 -37 . Three grids providing progressively higher grid resolution are used to quantify the effect of grid resolution on the lift, drag, pitching moment, surface pressure and stall angle. SA results, as compared to SST results, exhibit better agreement with the measured data. However, both turbulence models under-predict upper surface pressures near the wing tip region.
Echocardiographic speckle reduction comparison (2011)

In this paper, a detailed description and comparison of speckle reduction of medical ultrasound, and in particular echocardiography, is presented. Fifteen speckle reduction filters are described in a detailed fashion to facilitate implementation for research and evaluation. The filtering techniques considered include anisotropic diffusion, wavelet denoising, and local statistics. Common nomenclature and notation are adopted, to expedite comparison between approaches. Comparison of the filters is based on their application to simulated images, clinical videos, and a computational requirement analysis. The ultrasound simulation method provides a realistic model of the image acquisition process, and permits the use of a noise-free reference image for comparison. Application of objective quality metrics quantifies the preservation of image edges, overall image distortion, and improvement in image contrast. The computational analysis quantifies the number of operations required for each speckle reduction method. A speed-accuracy analysis of discretization methods for anisotropic diffusion is included. It is concluded that the optimal method is the OSRAD diffusion filter. This method is capable of strong speckle suppression, increasing the average SNRA of the simulated images by a factor of two. This method also shows favorable edge preservation and contrast improvement, and may be efficiently implemented.
On the mechanism of the Dakin–West reaction (2012)

The mechanism of the Dakin-West reaction has been thoroughly investigated by monitoring the reaction using ESI-MS/MS techniques in combination with M06-2X/6-311++G(d,p) calculations. Several of the key intermediates in the previously proposed "azlactone" mechanism have been experimentally detected and characterized. In particular, interception of the mixed anhydrides involved in the early and late stages of the mechanistic scheme, as well as of the cyclic acyl-oxazolone intermediate, supports the original pathway suggested by Dakin and West. All intermediates and transition structures involved in several competing mechanisms have been calculated. The theoretical calculations support the experimental results and corroborate the proposed "azlactone" mechanism. The pathway involving the cyclic oxazolone ("azlactone") intermediate represents an energy barrier more than 3 kcal mol(-1) lower than for the competing aldol-type mechanism, thus ruling out this alternative mechanism. The DFT calculations explain the observed ESI-MS data and assess those intermediates which the experiments cannot fully elucidate.
Adaptation of the projection-slice theorem for stock valuation estimation using random Markov fields (2009)

The Projection-Slice Synthetic Discriminant function filter is utilized with Random Markov Fields, RMF to estimate trends that may be used as prediction for stock valuation through the representation of the market behavior as a hidden Markov Model, HMM. In this work, we utilize a set of progressive and contiguous time segments of a given stock, and treat the set as a two dimensional object that has been represented by its one-d projections. The abstract two-D object is thus an incarnation of N-temporal projections. The HMM is then utilized to generate N+1 projections that maximizes the two-dimensional correlation peak between the data and the HMM-generated stochastic processes. This application of the PSDF provides a method of stock valuation prediction via the market stochastic behavior utilized in the filter.
Two-Round Oblivious Transfer from CDH or LPN (2020)

We show a new general approach for constructing maliciously-secure two-round oblivious transfer (OT). Specifically, we provide a generic sequence of transformations to upgrade a very basic notion of two-round OT, which we call elementary OT, to UC-secure OT. We then give simple constructions of elementary OT under the Computational Diffie-Hellman (CDH) assumption or the Learning Parity with Noise (LPN) assumption, yielding the first constructions of malicious (UC-secure) two-round OT under these assumptions. Since two-round OT is complete for two-round 2-party and multi-party computation in the malicious setting, we also achieve the first constructions of the latter under these assumptions.
Safrole induces G0/G1 phase arrest via inhibition of cyclin E and provokes apoptosis through endoplasmic reticulum stress and mitochondrion-dependent pathways in human leukemia HL-60 cells. (2012)

Safrole, a component of Piper betle inflorescence, is a carcinogen which has been demonstrated to induce apoptosis on human oral cancer HSC-3 cells in vitro and to inhibit HSC-3 cells in xenograft tumor cells in vivo. In our previous study, safrole promoted phagocytosis by macrophages and natural killer cell cytotoxicity in normal BALB/c mice. The cytotoxic effects of safrole on HL-60 cells were investigated by using flow cytometric analysis, comet assay, 4',6-diamidino-2-phenylindole (DAPI) staining, western blotting and confocal laser microscopy. The obtained results indicate that safrole induced a cytotoxic response through reducing the percentage of viable cells and induction of apoptosis in HL-60 cells in a dose-dependent manner. DAPI staining and comet assay also showed that safrole induced apoptosis (chromatin condensation) and DNA damage in HL-60 cells. The flow cytometric assay showed that safrole increased the production of reactive oxygen species (ROS) and Ca(2+) and reduced the mitochondrial membrane potential in HL-60 cells. Safrole enhanced the levels of the pro-apoptotic protein BAX, inhibited those of the anti-apoptotic protein BCL-2 and promoted the levels of apoptosis-inducing factor (AIF) and endonuclease G (Endo G) in HL-60 cells. Furthermore, safrole promoted the expression of glucose-regulated protein 78 (GRP78), growth arrest- and DNA damage-inducible gene 153 (GADD153) and of activating transcription factor 6α (ATF-6α). Based on these findings, we suggest that safrole-induced apoptosis in HL-60 cells is mediated through the ER stress and intrinsic signaling pathways.
Entanglement quantification and purification in continuous-variable systems (2000)

We develop theoretical and numerical tools for the quantification of entanglement in systems with continuous degrees of freedom. Continuous variable entanglement swapping is introduced and based on this idea we develop methods of entanglement purification for continuous variable systems. The success of these entanglement purification methods is then assessed using these tools.
Parasites of domestic owned cats in Europe: co-infestations and risk factors (2014)

This survey demonstrates that parasitism is not a rare event in European owned cat populations. The prevalence of multi-parasitism is significantly greater than expected by chance and hence there is tendency for some individual cats to be more prone to infestation by both endo- and ectoparasites due to common risk factors.
A Green Approach for the Synthesis of Fluorescent Polymer Particles by Combined Use of Enzymatic Miniemulsion Polymerization with Clickable Surfmer and Click Reaction (2014)

Herein, we describe a facile and green method to prepare fluorescent polymer particles by combined use of enzymatic miniemulsion polymerization and click reaction. Firstly, alkyne-bearing polymer particles were prepared by HRP-mediated miniemulsion polymerization of styrene with clickable surfmer (surfactant + monomer) 1. Then, azide-bearing fluorescence compound, i.e., dansyl azide compound 2, was introduced to polymer particles surface via click reaction using Cu(I) catalyst. This methodology will be applied to a broad range of azide-bearing compounds to generate functional polymer particles. Since both enzymatic miniemulsion polymerization and click reaction are conducted at room temperature in water, present method offers a practical and environmental friendly method for preparation of functional polymer particles.
Hyperbranched Polyalkoxysiloxanes via AB3‐Type Monomers (2003)

Abstract We have synthesized polyethoxysiloxanes starting from the AB 3 ‐type monomers triethoxysilanol and acetoxytriethoxysilane. The polymers are liquid and soluble in organic solvents. 29 Si NMR spectroscopy and MALDI‐ToF mass spectrometry analyses show that the polymers have a hyperbranched structure with additional internal cyclization. 29 Si NMR spectroscopy indicates that the polymer synthesized from acetoxytriethoxysilane is less branched than the polymer synthesized from triethoxysilanol. Analysis of the molar mass and mass distribution of the polymers via size exclusion chromatography (calibrated via MALDI‐ToF MS and viscosimetry) yields a molar mass of M n ≈ 2 kg · mol −1 and M w ≈ 8 kg · mol −1 for polymers synthesized from triethoxysilanol. The molar mass of the polymers synthesized from acetoxytriethoxysilane can be controlled by variation of the polymerization time in the range of M n ≈ 1.8–12 kg · mol −1 and M w ≈ 2.1–2 200 kg · mol −1 . Photograph of a vial containing polyethoxysiloxane obtained from triethoxysilanol and a schematic drawing of the proposed molecular structure of the polymer. magnified image Photograph of a vial containing polyethoxysiloxane obtained from triethoxysilanol and a schematic drawing of the proposed molecular structure of the polymer.
Demonstration of Temperature Measurement on a Curved Surface Using Thermographic Phosphors (2002)

An optical technique for surface temperature measurement based on the fluorescent emission of rare-earth ion-doped phosphors was demonstrated in an experiment with a heated cylinder in cross flow. In this experiment, a uniform heat flux is imposed by applying a constant voltage across the thin stainless-steel cylinder surface to produce surface temperatures between 24 deg. C and 55 deg. C. The fluorescent emission of a thermographic phosphor, lanthanum oxysulfide doped with europium (La2O2S:Eu+3) deposited on the surface, was recorded to determine the temperature distribution at the curved surface. when excited by ultraviolet radiation, the phosphor emits a spectrum containing certain emission lines, and the intensities of these vary with temperature.