gebhart/patrepeval huggingface dataset:
Thermal analysis of polymers (1997)

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Smart Sorting in Massive MIMO Detection (2018)

In this paper, we proposed a discrete sorting optimization approach for uplink channel of Massive Multiple Input, Multiple Output (MIMO) system. The algorithm includes users (UEs) sorting before QR decomposition (QRD) and sorting-reduced (SR) K-best detector for 48x64 MIMO uncoded systems. Simulation results show that detector losses is about 1dB to a Maximum Likelihood (ML) detection in low detector complexity.The UEs sorting is required to sort diagonal elements of the R matrix in ascending order to avoid error propagation in multi-user (MU) scenario. Fast and low complexity method of online discrete optimization is used to find the loss function minimum. Sorting tracking is proposed, so that the pre-sorted interpolated R matrix is used for further sorting optimization, resulting in low sorting complexity. The proposed sorting demonstrates huge performance gain compare to a common power-based one. Simulation results in 5G QuaDRiGa channel are presented.SR-K-best detector is a variant of K-best detector. The SR-K-best with (K,S,p) parameters results in significant losses in scenarios with high correlated users, therefore we proposed a new structure (K,S,p,v,q) of the SR-K-best algorithm and a new discrete optimization method to increase performance. Discrete stochastic optimization was done offline in QuaDRiGa channel to find optimal (K,S,p,v,q) parameters for fixed detector structure.
Javascript® bible, sixth edition (2007)

Make your Web pages stand out above the noise with JavaScript and the expert instruction in this much-anticipated update to the bestselling JavaScript Bible. With renowned JavaScript expert Danny Goodman at your side, you'll get a thorough grounding in JavaScript basics, see how it fits with current Web browsers, and find all the soup-to-nuts detail you'll need. Whether you're a veteran programmer or just starting out, this is the JavaScript book Web developers turn to again and again. Note: CD-ROM/DVD and other supplementary materials are not included as part of eBook file.
Transposon Tn5 (2008)

Tn5 was one of the first transposons to be identified ( 10 ). As a result of Tn5's early discovery and its simple macromolecular requirements for transposition, the Tn5 system has been a very productive tool for studying the molecular mechanism of DNA transposition. These studies are of broad value because they offer insights into DNA transposition in general, because DNA transposition is a useful model with which to understand other types of protein-DNA interactions such as retroviral DNA integration and the DNA cleavage events involved in immunoglobulin gene formation, and because Tn5-derived tools are useful adjuncts in genetic experimentation.
Structural Characterization of the Inhibitory DNA Motif for the Type A (D)-CpG–Induced Cytokine Secretion and NK-Cell Lytic Activity in Mouse Spleen Cells (2003)

Oligodeoxynucleotides (ODN) with the CpG motif have been shown to be potent stimulators of innate immunity. A theoretical concern is that uncontrolled stimulation of the innate immune system through the TLR-9 receptor could induce, or worsen, some autoimmune diseases such as adjuvant arthritis or systemic lupus erythematosus. Safe therapeutic use of such ODN could be enhanced if one could regulate some of their stimulatory activities. We have designed a group of synthetic ODNs, which were able to inhibit the induction of NK lytic activity, IL-12p40 and IFN-gamma cytokine secretion by type A (D)-CpG-ODNs. Inhibition occurred in both DNA-sequence and dose-dependent fashion. Fifty percent inhibition was achieved with ~10-nM concentration of the most potent inhibitory ODNs. Delayed addition of these ODNs for up to 2 h was still able to profoundly affect CpG-induced IL-12p40 production at 18 h. Inhibitory DNA motif consists of two nucleotide triplets, a proximal pyrimidine-rich CCT sequence and a more distal GGG triplet. Optimal distance between these blocks is between three to five nucleotides. The linker sequence between the CCT and GGG blocks can additionally modify the activity of inhibitory ODNs, in both a positive and in negative way. When the order of CCT and GGG blocks is reversed, inhibition is completely lost. These findings suggest that CpG regulation of innate immunity can itself be regulated by particular motifs, which could be of therapeutic benefit in autoimmune diseases.
Conception d'un ascenseur à poissons adapté à l'alose (Alosa alosa) sur un grand cours d'eau : I'ascenseur de Golfech sur la Garonne (1992)

Depuis 1971, année de mise en service de l'aménagement hydroélectrique de Golfech sur la Garonne, le passage de l'alose (alosa alosa) et des autres espèces migratrices à l'amont de I'ouvrage était très limité voire impossible. Dans cet article, les auteurs rapportent les principaux critères utilisés pour le dimensionnement d'un ascenseur à poissons implanté au droit de l'usine de Golfech. Sa conception est directement inspirée de celle de I'ascenseur à poissons du barrage de Holyoke sur la rivière Connecticut (USA). Deux modèles hydrauliques ont été utilisés pour choisir la situation des entrées et optimiser I'attractivité de I'ouvrage et les conditions hydrodynamiques dans la partie basse du dispositif. L'ascenseur a été construit en 1986-1987. Les poissons migrateurs sont attirés dans un grand bassin de stabulation par un débit d'attrait et piégés à I'aide d'une grille articulée jouant e rôle de nasse anti-retour. Cette grille, mécanisée et montée sur un chariot, sert également à pousser les poissons au-dessus d'une cuve située à l'extrémité amont du bassin de stabulation. Le débit d'attrait est injecté au travers de grilles verticales situées à l'amont de la cuve et sur les parois latérales du bassin de stabulation. Les poissons, remontés dans la cuve, sont déversés dans un canal de transfert qui leur permet de rejoindre le canal d'amenée de I'usine. L'ascenseur à poissons a été contrôlé en 1987 et 1988 à l'aide d'un dispositif de comptage vidéo automatisé de façon à en tester l'efficacité, à valider certains critères utilisés pour sa conception et à acquérir des informations sur les caractéristiques migratoires des différents espèces. Au cours des premières années de contrôle, 25 espèces ont emprunté le dispositif et de 14 000 à 66 000 aloses par an ont été comptabilisées.
Message from the AdaptiveCM 2018 Workshop Chairs (2018)

Presents the introductory welcome message from the conference proceedings. May include the conference officers' congratulations to all involved with the conference event and publication of the proceedings record.
[Combined treatment for malignant tumors using focal ethanol injections]. (2007)

The potential of focal ethanol injection therapy (FEIT) as a component of combined treatment for malignant tumors was investigated. Thirty-four patients with inoperable primary and recurrent liver cancer received 72 FEIT procedures at the Institute's Clinic - 16 males (47%) and 18 females (53%), aged 35-80, (average 57), (1991-2004). Forty-three metastatic foci - colorectal carcinoma (23), non-colorectal carcinoma (20) and hepatocellular carcinoma (11) - were detected. Size of metastatic foci ranged 3.2-27.8 cm3 (average 15.4+/-6.4 cm3), while those of hepatocellular carcinoma - 156.7-982.4 cm3, (average 492.4+/-136.8 cm3). All patients received regional endovascular chemotherapy, without any life-threatening complications. Reduction in focal size after FEIT for hepatocellular carcinoma ranged 490.2+/-136.8 - 41.8+/-14 cm3. One-, three- and five-year survival was 100, 80 and 60%, respectively. In cases of hepatocellular carcinoma, ethanol-treated foci shrank by 88.4% - from 15.5+/-1.6 to 1.8 +/- 0.3 cm3 (p<0.05). One-, and three-year survival rates were 83 and 14%, respectively. After ethanol ablation, size of metastatic foci fell by 79%, from 13.9+/-4.3 to 2.9+/-2.4 cm3 (p<0.05). One- and three-year survival rates were 91 and 13%, respectively.
Ultrafast method for scanning tunneling spectroscopy (2021)

A scanning tunneling microscope (STM) combines unique capabilities in imaging and spectroscopy with atomic precision, and it can obtain energy-resolved spectroscopic data with atomic resolution. In this paper, we utilize a recently proposed modification to the STM feedback control loop to acquire high quality d2I/dV2 images. We have developed a constant differential conductance imaging method by closing the STM feedback loop with a high precision dI/dV measurement. In this mode, the tip’s vertical position is adjusted so as to keep the differential conductance constant during raster scanning of the surface. Based on this imaging mode, we propose a new technique to acquire fast and reliable scanning tunneling spectroscopy (STS) data simultaneously with the imaging.
Developing a Methodology for Testing of Hearing Protection Systems (2021)

Every day, individuals around the globe are exposed to noises that have devastating long-term effects on their hearing. Noise-Induced Hearing Loss (NIHL) is the second most common form of sensorineural hearing decline behind the age-related loss. NIHL can result from continuous exposure to high-intensity sounds such as heavy machinery or instantaneous exposure to extremely loud sounds, like gunshots and explosions. While passive hearing protection currently exists, the characterization and testing are limited mainly to pressure attenuation levels. There is limited research and information as to the frequency damping characteristics along with the linear and nonlinear performance. Further, the measure of these protections is quantified after creation, with limited criteria on how to design earplugs with desired characteristics. Here, we describe our progress in the development of methods to characterize the linear and nonlinear performance, frequency response, and damping characteristics, as well as investigating the correlation between material properties and performance.
Data from Human Monoclonal Antibody Fragments Binding to Insulin-like Growth Factors I and II with Picomolar Affinity (2023)

&lt;div&gt;Abstract&lt;p&gt;The type 1 insulin-like growth factor receptor (IGF1R) and its ligands (IGF-I and IGF-II) have been implicated in a variety of physiologic processes and in diseases such as cancer. In addition to IGF1R, IGF-II also activates the insulin receptor (IR) isoform A, and therefore, antibodies against IGF-II can inhibit cell proliferation mediated by the signaling through both IGF1R and IR triggered by IGF-II. We identified a new human monoclonal antibody (mAb), m708.2, which is bound to IGF-I and IGF-II but not to insulin. m708.2 potently inhibited signal transduction mediated by the interaction of IGF-I or IGF-II with the IGF1R and IGF-II with the IR. It also inhibited the growth of the breast cancer cell line MCF-7. An affinity-matured derivative of m708.2, m708.5, bound to IGF-I with equilibrium dissociation constant, &lt;i&gt;K&lt;/i&gt;&lt;sub&gt;D&lt;/sub&gt; = 200 pmol/L and to IGF-II with &lt;i&gt;K&lt;/i&gt;&lt;sub&gt;D&lt;/sub&gt; = 60 pmol/L. m708.5 inhibited signal transduction mediated by IGF-I and IGF-II and cancer cell growth more potently than m708.2. These results suggest that m708.5 could have potential as a candidate therapeutic for cancers driven by the IGF-I and IGF-II interactions with IGF1R and IR. &lt;i&gt;Mol Cancer Ther; 10(9); 1677–85. ©2011 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Ronchi test for characterization of nanofocusing optics at a hard x-ray free-electron laser (2012)

We demonstrate the use of the classical Ronchi test to characterize aberrations in focusing optics at a hard x-ray free-electron laser. A grating is placed close to the focus and the interference between the different orders after the grating is observed in the far field. Any aberrations in the beam or the optics will distort the interference fringes. The method is simple to implement and can provide single-shot information about the focusing quality. We used the Ronchi test to measure the aberrations in a nanofocusing Fresnel zone plate at the Linac Coherent Light Source at 8.194 keV.
Practical Lessons from Place Lab (2006)

This article takes a retrospective look at Place Lab, an Intel Research project on location-enhanced mobile computing. A community of researchers and practitioners have used Place Lab's software. The authors survey their research results as well as share lessons learned from leading the project and deploying Place Lab in the real world. This article is part of a special issue on Real-World Deployments.
Recreational physical activity and risk of benign proliferative epithelial disorders of the breast in women (1994)

The association between recreational physical activity and the risk of benign proliferative epithelial disorders (BPED) of the breast was examined in a case-control study conducted in Adelaide, Australia, between 1983 and 1985. The study included 383 incident, histologically confirmed cases of BPED identified through the major private pathology laboratory, 383 unbiopsied community controls matched to the cases for age and area of residence, and 192 controls whose biopsies did not show any signs of epithelial proliferation. Subjects reported their level of usual weekly physical activity in a self-administered questionnaire. When cases were compared with community controls, there was some evidence for a negative association between risk of BPED and total recreational physical activity. However, the reverse was observed when the cases were compared with biopsy controls. These patterns were essentially the same when examined by intensity of activity and by menopausal status. Despite the lack of an association between physical activity and risk BPED in this study, further investigation is warranted because of the potential benefits for the primary prevention of breast disease.
Radiosensitizing effects of 9401 on mice bearing H22 hepatoma (2013)

Objective To investigate the radiosensitizing effects of 9401 on mice bearing H22hepatoma.Methods Mouse model bearing H22 hepatoma cells were established.Mice were randomly divided into six groups,the control group,the radiation group and four treatment groups including 9401 at high,medium and low dosages and nicotinamide combined with radiation.After irradiated,the growth of tumor was observed,the time of tumor growth was recorded,the delay time of tumor growth and enhancement factor(EF)were calculated.After 28 days,the mice were killed,the tumors were stripped and inhibition rate was calculated.Results Groups of 9401 combined with radiation could pestpone tumor growth.The difference was statistically significant between 9401 groups at high,medium dosages combined with radiation and nicotinamide combined with radiation group (t=24.7 and 7.5,both P＜0.01).Compared with radiation alone group,groups of 9401 combined with radiation had significant radiosensitizing effect.The enhancement factor of 9401 combined with radiation groups at high and medium dosages were 2.13 and 1.73 respectively,they were significant higher than nicotinamide combined with radiation group (t=2.26 and 9.04,both P＜0.05).The inhibition rate of 9401 groups at high,medium and low dosages combined with radiation were 64.5％,50.9％ and 42.6％ respectively.The inhibition rate of nicotinamide group combined radiation was 53.2％.The inhibition rate of 9401 at high dosage combined with radiation had significant difference with nicotinamide combined radiation (t =2.8.P＜0.05).Nicotinamide combined with radiation group,9401 combined with radiation groups could significant inhibit the growth of tumors compared with radiation alone group (t=5.7,4.0 and 2.2,all P＜0.05).Conclusion 9401 can inhibit the tumor growth and the inhibition effect increases gradually with the drug dose increasing.It also has radiosensitizing effects on mice bearing H22hepatoma and present broadly clinical practice prospect.

Key words: 
Hepatoma; Radiation-sensitizing agents; Dose-response relationship, drug; Model, animal; Mice
The Effect of Direction and Reaction on the Neuromuscular and Biomechanical Characteristics of the Knee during Tasks that Simulate the Noncontact Anterior Cruciate Ligament Injury Mechanism (2005)

Jump direction significantly influenced knee biomechanics, suggesting that lateral jumps are the most dangerous of the stop-jumps. Reactive jumps were also significantly different, suggesting differences between planned laboratory experiments and actual athletic competition. The results of this study indicate that directional and reactive jumps should be included in research methodology and injury-prevention programs.
Assessment of creep behaviour of the die-cast cylinder-head alloy AlSi6Cu4-T6 (2006)

Abstract Mechanical properties of a T6-AlSi6Cu4 cylinder-head alloy are investigated at 4 stress levels up to 545 K through tensile and compressive test to assess creep damage. The effect of over-ageing for 200 h at comparable temperatures was studied through RT hardness tests. Creep behaviour was characterised by a minimum creep rate and an extended steady state was not observed. No threshold stresses were apparent from minimum creep rate vs. stress plots at any of the temperatures studied here. Apparent stress exponents were both temperature and stress dependent and the apparent creep activation energy was 2–3 times the lattice selfdiffusion activation energy for aluminium. The Norton plot was best described by an exponential relation. The total strain to failure exhibited a maximum for a particular applied stress and decreases for both higher and lower applied stress. Creep life is well described by the Monkman– Grant relation at the highest temperature, but exhibits deviations from the idealised behaviour at the lower test temperatures.
La gratte ou ciguatera : ses remèdes traditionnels dans le Pacifique Sud (1993)

Cementation to substrata during permanent attachment concludes the planktonic larval phase in many sessile marine invertebrates, including barnacles. However, the neural control and the mechanism of cement secretion from cement organs are poorly understood. In the present study, using isolated cement glands from cyprids of Megabalanus rosa, we have visualized cement secretion and demonstrated the stimulatory effect of dopamine and noradrenaline on such secretion. The abrupt disappearance of secretory granules and subsequent omega-figure formation indicated that exocytosis was the major mode of cement secretion. Exocytosis was localized at the apical surface of cement-secreting cells and lasted for over 30 min. Dopamine and noradrenaline also activated the directional transport of secretory granules to the sites of exocytosis. Glyoxylic acid staining provided histochemical evidence for catecholaminergic innervation to the cement glands. These results suggest that gradual, localized exocytotic secretion of cement triggered by catecholaminergic neurones is a key mechanism during permanent attachment by barnacle cyprids.
Robust Digital Watermarking Scheme using Contourlet Transform (2008)

Summary A novel oblivious and highly robust watermarking scheme using Multiple Descriptions (MD) and Quantization Index Modulation (QIM) of the host image is presented in this paper. The watermark is embedded in the Discrete Contourlet Transform domain (CT). Discrete Countourlet Transform (CT) is able to capture the directional edges and contours superior to Discrete Wavelet Transform (DWT). Watermark embedding is done at two stages for achieving robustness to various attacks. This algorithm is highly robust for different attacks on the watermarked image and superior in terms of Peak Signal to Noise Ratio (PSNR) and Normalized Cross correlation (NC). here the part of summary.
Creation of a Thermostable Firefly Luciferase with pH-insensitive Luminescent Color¶ (2003)

The thermal instability and pH-sensitive spectral property of firefly luciferase have hampered its use as a sensitive multicolor luminescent label or bioluminescent resonance energy transfer donor. With the intention of improving the thermostability of a previously found firefly Hotaria parvula luciferase mutant with minor pH-sensitive spectral change (V368A), further mutation (E356R) was introduced by taking a reportedly stabilized mutant of Photinus pyralis luciferase into account. The double mutant E356R/V368A showed significantly improved thermostability because > 90% activity remained after incubation for 1 h at 45 degrees C, with its specific activity being maintained. Unlike the wild type or V368A, E356R/V368A showed no change in the emission maximum of 568 nm even at pH 6.3, also implying a mutual relationship between thermostability and the proportion of yellow-green luminescent peak under acidic condition.
Scalable Synthesis of InAs Quantum Dots mediated through Indium Redox Chemistry (2020)

Next-generation optoelectronic applications\ncentered in the near-infrared\n(NIR) and short-wave infrared (SWIR) wavelength regimes require high-quality\nmaterials. Among these materials, colloidal InAs quantum dots (QDs)\nstand out as an infrared-active candidate material for biological\nimaging, lighting, and sensing applications. Despite significant development\nof their optical properties, the synthesis of InAs QDs still routinely\nrelies on hazardous, commercially unavailable precursors. Herein,\nwe describe a straightforward single hot injection procedure revolving\naround In­(I)Cl as the key precursor. Acting as a simultaneous reducing\nagent and In source, In­(I)Cl smoothly reacts with a tris­(amino)­arsenic\nprecursor to yield colloidal InAs quantitatively and at gram scale.\nTuning the reaction temperature produces InAs cores with a first excitonic\nabsorption feature in the range of 700–1400 nm. A dynamic disproportionation\nequilibrium between In­(I), In metal, and In­(III) opens up additional\nflexibility in precursor selection. CdSe shell growth on the produced\ncores enhances their optical properties, furnishing particles with\ncenter emission wavelengths between 1000 and 1500 nm and narrow photoluminescence\nfull-width at half-maximum (FWHM) of about 120 meV throughout. The\nsimplicity, scalability, and tunability of the disclosed precursor\nplatform are anticipated to inspire further research on In-based colloidal\nQDs.
Next generation diagnostics on cardiomyopathy (2014)

Cardiomyopathies are common, seemingly monogenic autosomal dominant cardiac disorders known as the primary cause of sudden cardiac death in young adults. These diseases are characterized by a remarkable genetic heterogeneity, which makes it difficult to unravel the causative mutation in a diagnostic laboratory that is very laborious and expensive by Sanger sequencing.

To circumvent these limitations, we explored solutions of high throughput sequencing of targeted exomes with the aim to implement this approach in routine diagnostics. As a first test we designed a capture microarray with the total genomic length of 1 Mbp that includes all exons/splicing sites of 130 genes involved in cardiovascular mendelian disorders and analyzed simultaneously four samples by multiplexing patients with cardiomyopathies or Long-QT syndrome. Pathogenic mutations and variants of unknown significance were found thus resolving the genetic causes of the cardiopathy in three. In the fourth patient the mutation usually associated with hypertrophic cardiomyopathy was found with Long-QT. Further developments to next generation diagnostics are now in progress, and will be also discussed.

In conclusion, high throughput sequencing holds considerable promises for molecular diagnosis of highly heterogeneous disorders in clinical practice and allows a better understanding of the complexity of mendelian disorders.