gebhart/patrepeval huggingface dataset:
Nitrogen 1s binding energy shifts detected from a homologous series of cyanine dyes (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNitrogen 1s binding energy shifts detected from a homologous series of cyanine dyesL. Gold and J. F. GiulianiCite this: J. Am. Chem. Soc. 1984, 106, 7, 2209–2210Publication Date (Print):April 1, 1984Publication History Published online1 May 2002Published inissue 1 April 1984https://pubs.acs.org/doi/10.1021/ja00319a050https://doi.org/10.1021/ja00319a050research-articleACS PublicationsRequest reuse permissionsArticle Views129Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Knockdown of TREK-1 in Hippocampal Neurons Attenuate Lipopolysaccharide-Induced Depressive-Like Behavior in Mice (2019)

TWIK-related potassium channel-1 (TREK-1) is broadly expressed in the brain and involved in diverse brain diseases, such as seizures, ischemia, and depression. However, the cell type-specific roles of TREK-1 in the brain are largely unknown. Here, we generated a Cre-dependent TREK-1 knockdown (Cd-TREK-1 KD) transgenic mouse containing a gene cassette for Cre-dependent TREK-1 short hairpin ribonucleic acid to regulate the cell type-specific TREK-1 expression. We confirmed the knockdown of TREK-1 by injecting adeno-associated virus (AAV) expressing Cre into the hippocampus of the mice. To study the role of hippocampal neuronal TREK-1 in a lipopolysaccharide (LPS)-induced depression model, we injected AAV-hSyn-BFP (nCTL group) or AAV-hSyn-BFP-Cre (nCre group) virus into the hippocampus of Cd-TREK-1 KD mice. Interestingly, the immobility in the tail suspension test after LPS treatment did not change in the nCre group. Additionally, some neurotrophic factors (BDNF, VEGF, and IGF-1) significantly increased more in the nCre group compared to the nCTL group after LPS treatment, but there was no difference in the expression of their receptors. Therefore, our data suggest that TREK-1 in the hippocampal neurons has antidepressant effects, and that Cd-TREK-1 KD mice are a valuable tool to reveal the cell type-specific roles of TREK-1 in the brain.
Incidence and Characteristics of Type‐2 Breaks in Response to Antitachycardia Pacing Therapy in Implantable Cardioverter Defibrillator Patients (2003)

Approximately 10% of VT episodes that were successfully terminated with burst ATP therapy had type-2 breaks. Type-2 breaks are associated with an increase in CL variability. Approximately 9% of all type-2 episodes may be spontaneously terminating nonsustained VT given that ATP did not affect these episodes in any way.
Compact hollow glass waveguide system for Er:YAG laser radiation (2005)

Hollow glass waveguide is one of a few instruments for the delivery of mid-infrared laser light favored in industrial and medical fields. The article summarizes delivery of the Er:YAG laser radiation (&lambda; = 2.94 &mu;m) by the cyclic olefin polymer coated silver hollow glass waveguides with different inner waveguide diameters (320 &mu;m, 700 &mu;m, 1 mm). For the medical applications, the so called "contact mode" in which the end of the waveguide is in contact with the soft or hard tissues is discussed. Delivery of free-running and Q-switched mid-infrared pulses was investigated.
In situ activity-based protein profiling of serine hydrolases in E. coli (2014)

A fluorophosphonate based alkyne activity probe was used for the selective labeling of active serine hydrolases in intact Escherichia coli cells. A biotin-azide tag was subsequently attached to the alkyne functionality of the probe with copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction. Comparison of proteins from in-cell and lysate labeled preparations suggested qualitatively similar patterns of reactivity in both preparations. Approximately 68%, 30 of the total 44 serine hydrolases detectable in E. coli were labeled with the probe indicating significant coverage with a single probe. The methods described here offer a useful tool for profiling and monitoring serine hydrolase activity in situ.
Plasminogen activator is an apparent lymphocyte mitogen. (1981)

Culture fluids of avian sarcoma virus (ASV)-transformed but not normal chicken embryo cells frequently elicited a mitogenic response in normal avian and murine lymphocytes. We examined the possibility that plasminogen activator (PA) might be responsible for the observed mitogenic effect. PA activity, present in culture medium, was correlated positively with lymphocyte mitogenic capacity. Treatment of cells with phorbol myristate acetate, which elevates PA levels, increased mitogenesis. Similar treatment with dexamethasone, which inhibits PA biosynthesis and/or secretion, reduced lymphocyte mitogenic activity. Addition to culture fluids of either benzamidine or diisopropylfluorophosphate, both specific PA inhibitors, blocked lymphocyte proliferative responsiveness to culture fluids. In contrast, neither epsilon-amino-caproic acid nor trasylol, which inhibits plasmin esterase activity but not PA, abrogated lymphocyte responsiveness. Furthermore, purified urokinase, an enzyme of similar substrate specificity to PA, had lymphocyte stimulatory activity. These results strongly suggest that PA can function as a lymphocyte mitogen.
Deciphering chiral structures in soft materials via resonant soft and tender X-ray scattering (2020)

Chirality is an essential research topic in material science, especially in soft materials including liquid crystals, polymers and biomaterials. There have been many discussions about chiral structures since people discovered and studied this particular property. Yet, due to the lack of effective characterization methods, many questions on helical structures of chiral materials remain unsolved. Here, we review recent applications of resonant soft (RSoXS) and tender resonant X-ray scattering (TReXS) on chirality study in soft materials, with a focus on liquid crystals phases. In the end, a perspective is presented on the potential applications and future improvements of resonant scattering.
Prospects of obtaining favourable fatty acidcomposition of cows milk by feeding (2007)

Information from the literature and own data show that the ratio of unsaturated to saturated fatty acids in milk fat, the level of CLA and -3 fatty acids can be improved by dietary factors. However, none of the components can be changed without a concomitant increase in trans fatty acids, some with unknown human health effects. Diets that effectively affect milk fat composition, often lead to milk fat depression due to inhibition of expression of the genes coding for key enzymes. Potential negative effects on technological and sensory quality cannot be ignored.
Understanding Robocup-Soccer Narratives (2011)

We present an approach to map Robocup-soccer narratives (in natural language) to a sequence of meaningful events and use them to answer semantic questions about the narratives. Our approach takes advantage of an action-centered framework, an inference subroutine, and an iterative learning algorithm. Our framework represents the narrative as a sequence of sentences and each sentence as a probability distribution over deterministic events. Our learning algorithm maps sentences to meaningful events without any annotated labeled data. Instead, it uses a prior knowledge about event descriptions and an inference subroutine to estimate initial training labels. The algorithm further improves the training labels at next iterations. In our experiments we demonstrate that with no labeled data our algorithm achieves higher accuracy compared to the state of the art that uses labeled data. 1
5' sequence of porcine and rat pro-opiomelanocortin mRNA. One porcine and two rat forms. (1984)

We have determined the nucleotide sequences of the 5' noncoding regions and the regions encoding the first 56 amino acids of rat and porcine pro-opiomelanocortin (POMC) mRNA. We accomplished this by sequencing cDNA produced by elongating specific DNA primers hybridized to neurointermediate pituitary mRNA. The nucleotide sequence of the 5' region of rat POMC mRNA fills a gap in our knowledge of the structure of this mRNA and the protein it codes for. While we have observed only a single porcine POMC mRNA, two different rat POMC mRNAs are detected. The rat POMC mRNAs differ by a 30-base insertion/deletion in their 5' noncoding regions. Its position and sequence suggest that it is the result of alternate modes of intron removal during RNA splicing.
Molecular Cloning and Characterization of Human GnT-IX, a Novel β1,6-N-Acetylglucosaminyltransferase That Is Specifically Expressed in the Brain (2003)

A novel beta1,6-N-acetylglucosaminyltransferase (beta1, 6GnT) cDNA was identified by a BLAST search using the amino acid sequence of human GnT-V as a query. The full-length sequence was determined by a combination of 5'-rapid amplification of cDNA end analysis and a further data base search. The open reading frame encodes a 792 amino acid protein with a type II membrane protein structure typical of glycosyltransferases. The entire sequence identity to human GnT-V is 42%. When pyridylaminated (PA) agalacto biantennary N-linked oligosaccharide was used as an acceptor substrate, the recombinant enzyme generated a novel product other than the expected GnT-V product, (GlcNAcbeta1,2-Manalpha1,3-)[GlcNAcbeta1,2-(GlcNAcbeta1,6-)Manalpha1,6-]Manbeta1,4-GlcNAcbeta1,4-GlcNAc-PA. This new product was identified as [GlcNAcbeta1,2-(GlcNAcbeta1,6-)Manalpha1,3-][Glc-NAcbeta1,2-(GlcNAcbeta1,6-)Manalpha1,6-]Manbeta1,4-GlcNAcbeta1,4-GlcNAc-PA by mass spectrometry and 1H NMR. Namely, the new GnT (designated as GnT-IX) has beta1,6GnT activity not only to the alpha1,6-linked mannose arm but also to the alpha1,3-linked mannose arm of N-glycan, forming a unique structure that has not been reported to date. Northern blot analysis showed that the GnT-IX gene is exclusively expressed in the brain, whereas the GnT-V gene is expressed ubiquitously. These results suggest that GnT-IX is responsible for the synthesis of a unique oligosaccharide structure in the brain.
Novel phenotype of RNA synthesis expressed by vesicular stomatitis virus isolated from persistent infection (1982)

Vesicular stomatitis virus (VSV) stocks isolated from two persistently infected mouse L-cell lines (designated VSV-PI stocks) express an altered phenotype of RNA synthesis. This phenotype is different from the RNA synthesis phenotype expressed by the viruses used to initiate the persistently infected lines, wild-type VSV and VSV ts-0-23 (a group III, ts-, RNA+ mutant). At 34 and 37 degrees C in L cells productively infected with VSV-PI stocks derived from the two cell lines, transcription of virus mRNA was significantly reduced, whereas replication of the 40S genomic RNA species was enhanced compared with wild-type VSV or ts-0-23. At 34 and 37 degrees C, both VSV-PI stocks replicated with equal or greater efficiency than wild-type VSV; 37 degrees C was the temperature at which the persistently infected cultures were maintained. At 40 degrees C, both VSV-PI stocks were temperature sensitive, and clonal VSV-PI isolates from both cell lines belong to complementation group I (RNA-). Standard ts- mutants (derived by mutagenesis of wild-type VSV) belonging to RNA- complementation groups I, II, and IV do not express the VSV-PI RNA synthesis phenotype at the permissive temperature, making this phenotype distinctive to persistent infection. Since the two VSV-PI populations from persistently infected cell lines initiated with different viruses both evolved this unique phenotype of RNA synthesis, the expression of this phenotype may play an important role in the maintenance of persistence.
Anticitrullinated protein antibodies: origin and role in the pathogenesis of rheumatoid arthritis (2016)

ACPAs target proteins/peptides with citrullinated epitopes and serve as informative RA biomarkers. ACPAs are generated within synovium and possibly at extra-articular sites prior to disease onset. Proximate to RA onset, critical qualitative and quantitative changes to ACPAs occur that drive proinflammatory responses. Unable to induce arthritis alone, the administration of ACPAs enhances the development and severity of inflammation in mice when a mild synovitis is already present. In vitro studies have elucidated several possible mechanisms linking ACPA to disease progression including: first, activation of inflammatory cells by ACPA-immune complexes; second, ACPA-mediated neutrophil cell death producing neutrophil extracellular traps, which drives inflammation and autoimmunity by releasing citrullinated autoantigen; and finally, direct binding of ACPAs to osteoclasts and resulting osteoclastogenesis. Together, these recent investigations have begun to elucidate the different mechanisms by which ACPAs may be directly pathogenic in RA.
A biomechanical study of the triple jump (1981)

The purpose of this study was to investigate the triple jump from the viewpoint of the velocity of the center of gravity and the mechanical energy. Eight 16 mm cameras were used to film the whole motion of 15 triple-jumpers from the end of the run-up to the landing of the jump. The horizontal velocity decreased during the first half of each take-off and increased during the second half. However, the absolute value of the velocity decreased from hop-to-step and from step-to-jump (the reductions were 8.5% and 15.1%, respectively). The vertical velocity increased at an almost constant rate during each take-off. The maximum height of the center of gravity was similar during the flights in the hop and the jump, and in the step it was approximately 10% lower than in the hop and the jump. The mechanical energy decreased after each take-off. Four percent of the mechanical energy acquired during the run-up was lost during take-off for the hop. The maintenance ratio was much lower (approximately 85%) for the step and the jump.
Comparison of lansoprazole‐based triple and dual therapy for treatment of Helicobacter pylori‐related duodenal ulcer: an Asian multicentre double‐blind randomized placebo controlled study (2000)

This Asian multicentre study showed that 1-week lansoprazole-based triple therapy without clarithromycin has similar efficacy in H. pylori eradication and ulcer healing compared with a 2-week regimen. Both triple therapies were significantly better than dual therapy in H. pylori eradication. Therefore, 1-week lansoprazole-based triple therapy is as safe and effective as 2-week therapy in eradication of H. pylori infection and healing of duodenal ulcer in these Asian centres.
Granulin-Epithelin Precursor Is an Oncofetal Protein Defining Hepatic Cancer Stem Cells (2011)

Our findings demonstrate that GEP is a hepatic oncofetal protein regulating ES cell-related signaling molecules. Co-expression of GEP and ABCB5 further enriches a subpopulation with enhanced CSC properties. The current data provide new insight into the therapeutic strategy.
Materials Approach to Fuel Efficient Tires (2015)

The objective of this project was to design, develop, and demonstrate fuel efficient and safety regulation compliant tire filler and barrier coating technologies that will improve overall fuel efficiency by at least 2%. The program developed and validated two complementary approaches to improving fuel efficiency through tire improvements. The first technology was a modified silica-based product that is 15% lower in cost and/or enables a 10% improvement in tread wear while maintaining the already demonstrated minimum of 2% improvement in average fuel efficiency. The second technology was a barrier coating with reduced oxygen transmission rate compared to the state-of-the-art halobutyl rubber inner liners that will provide extended placarded tire pressure retention at significantly reduced material usage. A lower-permeance, thinner inner liner coating which retains tire pressure was expected to deliver the additional 2% reduction in fleet fuel consumption. From the 2006 Transportation Research Board Report1, a 10 percent reduction in rolling resistance can reduce consumer fuel expenditures by 1 to 2 percent for typical vehicles. This savings is equivalent to 6 to 12 gallons per year. A 1 psi drop in inflation pressure increases the tire's rolling resistance by about 1.4 percent.
Strength and Fractography of Piezoceramic Multilayer Stacks (2005)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Deep LUMO Level Diimide π-Electron Core (2019)

Key words benzo[c]thiophene diimide - n-type organic semiconductor - organic field-effect transistor
Oxidative stress induces amyloid-like aggregate formation of NACP/α-synuclein in vitro (1999)

The precursor of non-amyloid beta protein component of Alzheimer's disease amyloid (NACP/alpha-synuclein), found in Lewy bodies of Parkinson's disease (PD), is a presynaptic protein genetically linked to some familial types PD. Mechanisms of abnormal NACP/alpha-synuclein aggregation in neurodegenerative diseases are unclear. Since oxidative stress might play a role in PD pathogenesis, we investigated the role of iron and peroxide in NACP/alpha-synuclein aggregation. Immunoblot analysis showed that human NACP/alpha-synuclein (but not beta-synuclein) aggregated in the presence of ferric ion and was inhibited by the iron chelator deferoxamine. Ferrous ion was not effective by itself, but it potentially aggregated NACP/alpha-synuclein in the presence of hydrogen peroxide. NACP/ alpha-synuclein aggregates displayed strong thioflavine-S and congo-red reactivity, reminiscent of amyloid. This study suggests that NACP/alpha-synuclein aggregation might be closely related to oxidative reactions which may play a critical role in neurodegeneration in disorders with Lewy bodies.
The establishment of a rheumatoid arthritis primate model in Macaca fascicularis (2020)

Abstract Background Rheumatoid arthritis (RA) is a long-term autoimmune disorder that mostly affects the joints and leads to the destruction of cartilage. An RA model in non-human primates is especially useful because of their close phylogenetic relationship to humans in terms of cross-reactivity to compounds developed using modern drug technologies.Methods We used a collagen-induced arthritis (CIA) model in cynomolgus monkeys. CIA was induced by the immunization of chicken type II collagen. Swelling was measured as the longitudinal and transverse axes of 16 proximal interphalangeal joints.Results A new system for visual evaluation was created, with a perfect score of 16. Individual behavioral analysis was also conducted. Serum was collected once a week after the first immunization. Blood chemistry and inflammatory cytokine parameters were higher in the CIA group than in the wild type group.Conclusion In conclusion, we established CIA in cynomolgus monkeys, and the results can be used for drug evaluation models.
In Vitro and in Vivo Aggregation of a Fragment of Huntingtin Protein Directly Causes Free Radical Production (2011)

Neurodegenerative diseases are characterized by intra- and/or extracellular protein aggregation and oxidative stress. Intense attention has been paid to whether protein aggregation itself contributes to abnormal production of free radicals and ensuing cellular oxidative damage. Although this question has been investigated in the context of extracellular protein aggregation, it remains unclear whether protein aggregation inside cells alters the redox homeostasis. To address this, we have used in vitro and in vivo (cellular) models of Huntington disease, one of nine polyglutamine (poly(Q)) disorders, and examined the causal relationship among intracellular protein aggregation, reactive oxygen species (ROS) production, and toxicity. Live imaging of cells expressing a fragment of huntingtin (httExon1) with a poly(Q) expansion shows increased ROS production preceding cell death. ROS production is poly(Q) length-dependent and not due to the httExon 1 flanking sequence. Aggregation inhibition by the MW7 intrabody and Pgl-135 treatment abolishes ROS production, showing that increased ROS is caused by poly(Q) aggregation itself. To examine this hypothesis further, we determined whether aggregation of poly(Q) peptides in vitro generated free radicals. Monitoring poly(Q) protein aggregation using atomic force microscopy and hydrogen peroxide (H(2)O(2)) production over time in parallel we show that oligomerization of httEx1Q53 results in early generation of H(2)O(2). Inhibition of poly(Q) oligomerization by the single chain antibody MW7 abrogates H(2)O(2) formation. These results demonstrate that intracellular protein aggregation directly causes free radical production, and targeting potentially toxic poly(Q) oligomers may constitute a therapeutic target to counteract oxidative stress in poly(Q) diseases.
Mechanisms for selective coalescence of coals: Fossil Energy quarterly report, 1 October 1987--31 December 1987 (1987)

The overall objective is to determine the basic mechanisms which underlie a number of selective coalescence or oil agglomeration processes that have been proposed for beneficiating fine-size coal. Recent work has shown that the oil agglomeration recovery of less hydrophobic Illinois No. 6 coal is reduced by an increase on ionic strength of the suspending medium. Also the oil agglomeration recovery of iron pyrite is reduced by an increase in ionic strength and the reduction is affected by the cations present. Thus, pyrite recovery is affected increasingly by Na/sup +/, Ca/sup + +/, and Mg/sup + +/ ions in that order. To study the effect of mild surface oxidation on the oil agglomeration of Pittsburgh seam coal, a freshly ground sample of the coal was exposed to air at room temperature for one week. When agglomerated with heptane, the recovery from neutral or acidic suspensions was similar to that of untreated coal, but the recovery from basic suspensions was lower than that of untreated coal. The total sulfur content of the agglomerated product was significantly lower for the treated coal. The use of magnesium salts as selective depressants for pyrite was investigated and found to be very effective in themore » separation of a synthetic mixture of hydrophobic Upper Freeport coal and pyrite by oil agglomeration. However, when a magnesium salt was applied to the separation of a synthetic mixture of the less hydrophobic Illinois No. 6 coal and pyrite, both coal and pyrite were depressed. 3 refs., 12 figs., 4 tabs.« less