gebhart/patrepeval huggingface dataset:
Higher-End Serotonin Receptors:  5-HT5, 5-HT6, and 5-HT7 (2003)

ADVERTISEMENT RETURN TO ISSUEPerspectiveNEXTHigher-End Serotonin Receptors: 5-HT5, 5-HT6, and 5-HT7Richard A. GlennonView Author Information Department of Medicinal Chemistry, School of Pharmacy, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298-0540 Cite this: J. Med. Chem. 2003, 46, 14, 2795–2812Publication Date (Web):June 11, 2003Publication History Received17 January 2003Published online11 June 2003Published inissue 1 July 2003https://pubs.acs.org/doi/10.1021/jm030030nhttps://doi.org/10.1021/jm030030nreview-articleACS PublicationsCopyright © 2003 American Chemical SocietyRequest reuse permissionsArticle Views1867Altmetric-Citations136LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Agonists,Antagonists,Receptors,Rodent models,Selectivity Get e-Alerts
X-ray phase contrast imaging by compact Talbot–Lau interferometer with a single transmission grating (2014)

We performed x-ray phase contrast imaging (XPCI) by Talbot-Lau interferometer using only a single transmission grating. Multiline metal targets embedded in a diamond substrate were irradiated with electrons to generate an array of x-ray lines of 1 μm width, which allowed XPCI within a 1 m source-detector distance in a configuration without a source or absorption grating. We directly resolved the self-image of the phase grating of 3 μm pitch using an x-ray image detector of 24 μm pixel size and successfully obtained absorption, differential phase, and dark-field images for 8 keV x rays.
Données nouvelles sur la prévention nutritionnelle de l’ostéoporose (2005)

With the human race experiencing a progressive increase in life expectancy, we are facing a growing prevalence of chronic age-related conditions, among which osteoporosis is a generalised condition of bone, whose hallmark is increased bone fragility. Based on the overwhelming body of evidence emphasising that gonadal failure at the time of menopause causes osteopenia and the administration of estrogens in postmenopausal women prevents this loss, hormone replacement therapy (HRT) has been widely recommended. However HRT should be limited due to its potential adverse effects. In this light, an effort should be made to integrate alternative therapies of proven values to provide new options for women in midlife. Research in nutrition over the past 30 years has led to exciting and significant progress. Although the primary role of diet is to provide sufficient nutrients to fulfill the metabolic requirements of an individual, there is an emerging rationale to support the hypothesis that, by modulating specific target functions in the body, diet can help to achieve optimal health and also play an important role in reducing the risk of disease. Specifically, it has been recognized that human diet contains, in addition to essential macro- and micronutrients, a complex array of naturally occurring bioactive molecules, the phytochemicals, that may confer significant long-term health benefits. Indeed, besides calcium, micronutrients such as vitamins, polyphenols, phytoestrogens, trace elements or minerals remain a source for putative new and innovative dietary health intervention in the nutritional prevention of osteoporosis.
Fabrication and testing of an integrated thermal flow sensor employing thermal isolation by a porous silicon membrane over an air cavity (2004)

In this work, an integrated thermal gas flow sensor was fabricated and evaluated using a new thermal isolation technique based on a porous silicon membrane over an air cavity in silicon. The fabrication process of a thermal gas flow sensor employing this type of micro-hotplate is described together with the theoretical estimation of the thermal distribution around the heater of the sensor. Experimental results of the thermal isolation achieved are shown. A flow evaluation of the sensor is presented and discussed. All the results obtained are compared with the corresponding ones for an identical sensor using a micro-hotplate made of porous silicon membrane but without the air cavity underneath. The improvement achieved by the air cavity is evaluated.
Costs and benefits of ant attendance to the drepanosiphid aphid Tuberculatus quercicola (2000)

The defensive effects of ants against aphid predators have been well documented in the mutualistic relationship of aphids and their attending ants. However, it is not clear whether ant attendance has any direct effect on the aphids’ growth and reproduction. Through field experiments, this study evaluates the benefits and, in particular, the costs of ant attendance to aphid colonies, focusing on the drepanosiphid aphid Tuberculatus quercicola which is associated with the Daimyo oak, Quercus dentata , and which is always attended by the red wood ant Formica yessensis . Ant attendance was clearly beneficial to the aphid; the exclusion of ants led to a significant increase in the extinction rate of aphid colonies. However, MANOVA and randomized block ANOVA indicated that in colonies continuously attended by ants, aphids had significantly smaller body size and produced a smaller number of embryos than in colonies isolated from ants when they were reared under homogeneous host conditions free from natural enemies. Thus, ant attendance had a negative influence on the growth and reproduction of the aphids, even though it contributed to the greater longevity of the aphid colonies. We hypothesize that ant‐attended aphids are under intense selective pressures that act against aphid clones which fail to attract many ants, so that aphids have developed an adaptive mechanism to allocate a larger fraction of resources to the honeydew when they are requested to do so by the ants in order to ensure the ants’ consistent visitation.
PRL-3: A phosphatase for metastasis? (2004)

The PRL-3 phosphatase has joined the cancer arena very recently but is rapidly gaining interest both as a putative prognostic factor and as a therapeutic target for metastatic tumors. In this issue Guo and colleagues provide another key piece of information by showing that the catalytic activity of PRL-3 is required for experimental metastasis formation in mouse models. Here we summarize the current knowledge and discuss what remains to be done before PRL-3 could be considered as a target for diagnostics or therapeutics in the clinical setting of human cancer.
Performance enhancement in cellular networks with dynamic cell sizing (2002)

This paper investigates the potential capacity improvements made possible through the use of dynamic cell sizing in a cellular network. The purpose of dynamic cell sizing is to reduce cell radii and thus enable in-cell users to increase their transmit powers. The use of higher transmit powers suppresses intercell interference and leads to an overall increase in capacity. This paper discusses the degree of capacity enhancement that can be achieved in this manner. The analysis indicates that the capacity of a single cell can be increased by as much as 38%. However, under uniform traffic conditions, this results in a ratio of supported-to-offered traffic of just 0.2, which is clearly unsatisfactory. Dynamic cell sizing performs significantly better in hot-spot conditions, where the in-cell traffic follows a normal distribution with the highest density in close proximity to the base station. The ratio of supported-to-offered traffic under these conditions was found to rise to 0.6 to 1.0 depending on the traffic standard deviation and the location of the hot spot.
Municipalities step up water treatment systems to improve public health (2005)

In Canada and the US, municipalities with surface water are stepping up water treatment systems to improve public health — increasing the level of protection from exposure to Cryptosporidium and Giardia. Membrane-based systems developed by Zenon Environmental are providing a physical barrier that prevents microbial contamination, as this brief case study reveals.
Exploring Contextual Information in a Layered Framework for Group Action Recognition (2006)

Contextual information is important for sequence modeling. Hidden Markov Models (HMMs) and extensions, which have been widely used for sequence modeling, make simplifying, often unrealistic assumptions on the conditional independence of observations given the class labels, thus cannot accommodate overlapping features or long-term contextual information. In this paper, we introduce a principled layered framework with three implementation methods that take into account contextual information (as available in the whole or part of the sequence). The first two methods are based on state alpha and gamma posteriors (as usually referred to in the HMM formalism). The third method is based on Conditional Random Fields (CRFs), a conditional model that relaxes the independent assumption on the observations required by HMMs for computational tractability. We illustrate our methods with the application of recognizing group actions in meetings. Experiments and comparison with standard HMM baseline showed the validity of the proposed approach. 1
Stable aqueous dispersions of polyaniline (1992)

Relatively concentrated stable aqueous dispersions of polyaniline containing uniform spherical particles have been prepared for the first time using a underivatised poly(vinyl alcohol coacetate) as a steric stabilizer.
Vulcan: Hardware Support for Detecting Sequential Consistency Violations Dynamically (2012)

Past work has focused on detecting data races as proxies for Sequential Consistency (SC) violations. However, most data races do not violate SC. In addition, lock-free data structures and synchronization libraries sometimes explicitly employ data races but rely on SC semantics for correctness. Consequently, to uncover SC violations, we need to develop a more precise technique. This paper presents Vulcan, the first hardware scheme to precisely detect SC violations at runtime, in programs running on a relaxed-consistency machine. The scheme leverages cache coherence protocol transactions to dynamically detect cycles in memory access orders across threads. When one such cycle is about to occur, an exception is triggered. For the conditions considered in this paper and with enough hardware, Vulcan suffers neither false positives nor false negatives. In addition, Vulcan induces negligible execution overhead, requires no help from the software, and only takes as input the program executable. Experimental results show that Vulcan detects three new SC violation bugs in the Pthread and Crypt libraries, and in the fmm code from SPLASH-2. Moreover, Vulcan's negligible execution overhead makes it suitable for on-the-fly use.
Brain natriuretic peptide: a potential marker for mortality in septic shock (2004)

Brain natriuretic peptide (BNP) is a diagnostic marker for left ventricular dysfunction. Sepsis and septic shock are increasing in incidence and mortality. Myocardial dysfunction frequently accompanies severe sepsis and septic shock. Although previously described as a preterminal event, ventricular dysfunction with reduced ejection fraction and biventricular dilatation is present in most patients with severe sepsis and septic shock. In survivors, this depression in cardiac function is reversible over the course of seven to ten days. Even though some prognostic factors have been identified in patients with sepsis-induced myocardial dysfunction, their measurement often includes costly and cumbersome techniques. Thus, there is a need for an inexpensive, simple, rapid and readily available marker to predict mortality in septic shock. At present, a relationship between BNP with myocardial dysfunction in septic shock has not been evaluated. However, growing evidence supports the hypothesis that BNP could be an early predictor of mortality in septic shock. If proven, the hypothesis would have important clinical and public health implications.
The Analysis of Theophylline By HPLC (1978)

Abstract Theophylline is a drug used in the treatment of asthma. Its therapeutic value is dependent upon its concentration in the blood with levels greater than 20 mg/1 causing side affects, sometimes severe. Various people metabolize the drug at different rates, so a method for analyzing serum Theophylline is necessary. We have developed a rapid, quantitative HPLC method for the analysis of serum Theophylline. No pretreatment of the sample is necessary, the method uses direct injection of the serum sample onto a guard column.
Response of a grid forming wind farm to system events, and the impact of external and internal damping (2020)

Following from smaller‐scale investigations of grid‐forming converter control applied to wind turbines in 2017–2018, this study describes a much larger trial involving an entire wind farm, owned and operated by ScottishPower Renewables. To the authors’ knowledge, this was the first UK converter‐connected wind farm to operate in grid‐forming mode, and the largest in the world to date. The 23‐turbine, 69 MW farm ran in the grid‐forming mode for 6 weeks, exploring inertia contributions between H = 0.2 s and H = 8 s. A number of unscheduled frequency disturbances occurred due to interconnector, combined cycle gas turbine (CCGT) and other trips, to which un‐curtailed turbines were able to respond. In addition, several deliberate tests were carried out. The turbines were able to provide a stable and appropriate response at relatively high inertia levels to the frequency events commonly occurring today. The captured responses stimulated a debate as to whether external damping power might be required in a grid‐forming converter, or whether internal damping is sufficient to allow stable and robust power‐sharing with parallel devices in all grid event scenarios. Analysis in this study suggests that, practically, internal damping is probably appropriate, and that any deficiency in external damping power can be more than mitigated by reactance and/or droop‐slope response‐time management in the grid‐forming converters.
[Modification of carbon flux in Sacchromyces cerevisiae to improve L-lactic acid production]. (2011)

The carbon metabolic flux was redistributed to efficient accumulation of L-lactic acid through two-sided control that heterologous expression of the gene LDH and decreasing the ratio of NADH/NAD+.
Recurrent adult onset Henoch-Schonlein Purpura: a case report (2016)

Henoch-Schonlein purpura is an immunoglobulin A (IgA)-immune complex mediated leukocytoclastic vasculitis that classically manifests with palpable purpura, abdominal pain, arthritis, and hematuria or proteinuria. The condition is much more predominant in children (90% of cases) and commonly follows an upper respiratory infection. We present a case of recurrent Henoch-Schonlein purpura (HSP) complicated by nephritis in an adult female initially categorized as IgA nephropathy (IgAN). We review the pathophysiologic basis of HSP nephritis as the variant of HSP accompanied by renal involvement and its pathogenetic commonality with IgA nephropathy.
1458: The in vitro and in vivo Evaluation of Lidocaine on Rat Muscle-Derived Cells for Treatment of Stress Urinary Incontinence (2007)

You have accessJournal of UrologyModerated Poster 45, Tuesday, May 22, 2007, 1:00 - 3:00 pm1 Apr 20071458: The in vitro and in vivo Evaluation of Lidocaine on Rat Muscle-Derived Cells for Treatment of Stress Urinary Incontinence Dae Kyung Kim, Ronald J. Jankowski, Ryan Pruchnic, Johnny Huard, Naoki Yoshimura, Masashi Honda, Akira Furuta, and Michael B. Chancellor Dae Kyung KimDae Kyung Kim More articles by this author , Ronald J. JankowskiRonald J. Jankowski More articles by this author , Ryan PruchnicRyan Pruchnic More articles by this author , Johnny HuardJohnny Huard More articles by this author , Naoki YoshimuraNaoki Yoshimura More articles by this author , Masashi HondaMasashi Honda More articles by this author , Akira FurutaAkira Furuta More articles by this author , and Michael B. ChancellorMichael B. Chancellor More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)31659-8AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "1458: The in vitro and in vivo Evaluation of Lidocaine on Rat Muscle-Derived Cells for Treatment of Stress Urinary Incontinence." The Journal of Urology, 177(4S), p. 481 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 177Issue 4SApril 2007Page: 481 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Dae Kyung Kim More articles by this author Ronald J. Jankowski More articles by this author Ryan Pruchnic More articles by this author Johnny Huard More articles by this author Naoki Yoshimura More articles by this author Masashi Honda More articles by this author Akira Furuta More articles by this author Michael B. Chancellor More articles by this author Expand All Advertisement PDF downloadLoading ...
Analysis of Blood and Other Body Fluids by Gas Chromatography: Simplified, Rapid Separation and Quantitation of Toxicologic Substances (1970)

Journal Article Analysis of Blood and Other Body Fluids by Gas Chromatography: Simplified, Rapid Separation and Quantitation of Toxicologic Substances Get access R. W. Reid, M.S., R. W. Reid, M.S. Clinical Laboratory Section, Veterans Administration Hospital, Hines, Illinois 60141 Hines, Illinois 60141 Search for other works by this author on: Oxford Academic Google Scholar R. Katzen,, M.S., R. Katzen,, M.S. Clinical Laboratory Section, Veterans Administration Hospital, Hines, Illinois 60141 Hines, Illinois 60141 Search for other works by this author on: Oxford Academic Google Scholar J. M. Clinger, M.D. J. M. Clinger, M.D. Clinical Laboratory Section, Veterans Administration Hospital, Hines, Illinois 60141 Hines, Illinois 60141 Search for other works by this author on: Oxford Academic Google Scholar American Journal of Clinical Pathology, Volume 53, Issue 4, 1 April 1970, Pages 462–467, https://doi.org/10.1093/ajcp/53.4.462 Published: 01 April 1970 Article history Received: 09 June 1969 Accepted: 29 September 1969 Published: 01 April 1970
The Effect of Self-Reported Diabetes on Alveolar Bone Loss and Number of Missing Teeth (2021)

Background: Diabetes mellitus, a major public health problem worldwide, is a known risk factor for periodontitis. Objective: This study aimed to investigate the effect of diabetes on periodontal health in a Saudi population by assessing alveolar bone level, and the number of missing teeth. Methods: In this retrospective study, the dental records of 203 patients (30–70 years old) patients (diabetic group = 102; control = 101) who visited King Abdulaziz University, Faculty of Dentistry, were examined through panoramic radiography. Bone loss measurements were carried out using the Ramfjord teeth index, and the number of missing teeth was counted for both groups. Independent t -test was used for comparing the total average represented by two group means, while Chi-square test was utilized to establish relationships between categorical variables. Results: The diabetic group had a significant 1.35-fold higher mean total bone loss (3.59 ± 1.37) compared to the control (2.66 ± 1.05). This was statistically significant in both genders ( p = 001) and in &gt;45 years old age group ( p &lt;0.05) . The number of missing teeth was significantly higher in diabetic patients compared to control patients, specifically when missing &gt;10 teeth and belonging to &gt;55 years old age group ( p &lt;0.05) . Conclusion: Our findings have shown a positive association between periodontal disease and diabetic patients, emphasizing the importance of early screening and diagnosis of diabetes and periodontitis in Saudi Arabia, which would help patients to avoid alveolar bone and tooth loss at early stages.
Articulatory speaker normalisation based on MRI-data using three-way linear decomposition methods (2012)

International audience
P1‐160: AUTOANTIBODIES IN ALZHEIMER'S DISEASE (2014)

A definitive diagnostic test for Alzheimer's disease (AD) has been difficult to achieve, despite decades of research. Therefore, there is a pressing need to identify disease-specific diagnostic biomarkers that can result in an early characterization of AD. Although AD is considered a degenerative disease, it is necessary to consider the immunological reactions in its pathophysiology. Of them, the concentration of anti-A β antibodies in the serum and/or cerebrospinal fluid of patients are considered to correspond with the development of AD. Immunofluorescence experiments were conducted on tissue substrates derived from the temporal cortex of one AD patient and one age-matched healthy control. The presence and distribution of Aβ-42 plaques and neurofibrillary tangles within the tissue substrates were confirmed using 3D6 and AT8 monoclonal antibodies, respectively. The tissue was cut into EUROIMMUN Biochips to facilitate the patient sample incubation. Neutralization experiments were conducted using commercial recombinant Aβ-42 peptide, in order to neutralize the binding of antibodies to Aβ-42. In addition, a monospecific dot blot technique was performed by spotting recombinant Aβ-42 (100 μg/ml) on a membrane. A high abundance of Aβ-42 plaques and tau tangles were observed in the AD tissue but not in the control. On incubating the sera from demented cases as well as age-matched controls with the tissue biochips, 4/44 patients revealed a plaque specific pattern. Surprisingly, it was noted that the Aβ-42 peptide had failed to neutralize the plaque pattern. In the dot blot, samples demonstrating a plaque pattern failed to detect the Aβ-42 peptide. We observed an unknown fluorescence pattern in the area of the plaques in 4/44 patients. Both IFT neutralization as well as dot blot experiments revealed that the plaque pattern was not specifically directed against Aβ-42 peptide.Few previously conducted studies have reported controversial results regarding the concentration and specificity of autoantibodies in AD. In the future, we aim to identify the other antigen(s) in question, since our results have excluded Aβ-42 as the specific antigen.
A novel dc - side commutated inverter (1980)

A new inverter with a single commutation circuit connected across the input dc bus is described. The inverter has inherent short circuit fuseless protection. The operation of the commutation circuit is described and a three phase inverter configuration is presented. The fuseless protection is then analyzed followed by a detailed procedure for a commutation circuit design. Finally, the efficiency of the new inverter is evaluated and is compared with that of the McMurray circuit for both six-step and PWM operation. The three phase inverter described in the paper has been built and has been laboratory tested.