gebhart/patrepeval huggingface dataset:
The Interface of Pancreatic Cancer With Diabetes, Obesity, and Inflammation: Research Gaps and Opportunities (2018)

A workshop on "The Interface of Pancreatic Cancer with Diabetes, Obesity, and Inflammation: Research Gaps and Opportunities" was held by the National Institute of Diabetes and Digestive and Kidney Diseases on October 12, 2017. The purpose of the workshop was to explore the relationship and possible mechanisms of the increased risk of pancreatic ductal adenocarcinoma (PDAC) related to diabetes, the role of altered intracellular energy metabolism in PDAC, the mechanisms and biomarkers of diabetes caused by PDAC, the mechanisms of the increased risk of PDAC associated with obesity, and the role of inflammatory events and mediators as contributing causes of the development of PDAC. Workshop faculty reviewed the state of the current knowledge in these areas and made recommendations for future research efforts. Further knowledge is needed to elucidate the basic mechanisms contributing to the role of hyperinsulinemia, hyperglycemia, adipokines, and acute and chronic inflammatory events on the development of PDAC.
Efficacy and safety of liraglutide in type 1 diabetes by baseline characteristics in the ADJUNCT ONE and ADJUNCT TWO randomized controlled trials (2021)

In ADJUNCT ONE and ADJUNCT TWO, the efficacy and glycaemic safety of liraglutide did not depend on subgroups, leaving residual beta-cell function as the only identified variable impacting the effect of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) in T1D. These findings support a role for GLP-1 RAs as adjuncts to insulin in T1D, warranting further study.
Integrating Imaging into Clinical Practice in Inflammatory Bowel Disease (2015)

Imaging is an important component for the monitoring of therapeutic success and disease control in patients with IBD. Colonoscopy is still the gold standard for imaging of disease activity. It is questionable, however, whether 'standard' or 'routine' imaging procedures max contribute to improved IBD therapy. There are good arguments for a problem driven imaging approach in IBD. Subsequently, the schedule of monitoring examinations should depend on the disease course (mild vs. severe) and the treatment used. Bowel ultrasound where available may substitute for endoscopy in many circumstances. New endoscopic techniques will be available at specialized centers for specific management questions. Applying these individualized strategies, imaging/monitoring will pay off for better disease control and better quality of life for IBD patients in the future.
Static and Dynamic Experimental Analysis of the Galloping Stability of Porous H-Section Beams (2014)

The phenomenon of self-induced vibrations of prismatic beams in a cross-flow has been studied for decades, but it is still of great interest due to their important effects in many different industrial applications. This paper presents the experimental study developed on a prismatic beam with H-section. The aim of this analysis is to add some additional insight into the behaviour of the flow around this type of bodies, in order to reduce galloping and even to avoid it. The influence of some relevant geometrical parameters that define the H-section on the translational galloping behaviour of these beams has been analysed. Wind loads coefficients have been measured through static wind tunnel tests and the Den Hartog criterion applied to elucidate the influence of geometrical parameters on the galloping properties of the bodies under consideration. These results have been completed with surface pressure distribution measurements and, besides, dynamic tests have been also performed to verify the static criterion. Finally, the morphology of the flow past the tested bodies has been visualised by using smoke visualization techniques. Since the rectangular section beam is a limiting case of the H-section configuration, the results here obtained are compared with the ones published in the literature concerning rectangular configurations; the agreement is satisfactory.
A New Method for the Preparation of A- and D-Rings of Phycocyanobilin Using Mucochloric Acid as a Starting Material (1995)

Abstract Diethyl 4-ethyl-1,5-dihydro-3-methyl-5-oxo-2H-pyrrol-2-ylphosphonate and 2-ethylidene-3-methyl-1-thiosuccinimide as D-and A-rings of phycocyanobilin dimethyl ester could be synthesized by using commercially available mucochloric acid as a starting material in good yields.
A hydraulic soft robotic detrusor based on an origami design (2023)

As a permanent solution for patients who cannot contract their urinary bladder, an artificial detrusor muscle appears a higher outcome approach compared to current sacral neurostimulators featured by severe long-term side effects. In this paper, a novel soft robotic detrusor is presented to overcome the limitations of the state-of-the-art solutions. It is based on two identical origami-based hydraulic actuators, which completely surround the bladder and contract upon water aspiration. Design, manufacturing, and experimental characterization both in terms of contraction capabilities and voiding efficiency on ex vivo swine bladders are reported for two different origami geometries, as well as a proof-of-concept implementation of an autonomous driving circuit as control unit. Results from assisted urination tests outlined very good performances proving an active voiding efficiency of the hydraulic soft robotic detrusor equal to 84.8% <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$\pm 7.4\%$</tex> in simulated environment.
Overview of Tigecycline Efficacy and Safety in the Treatment of Complicated Skin and Skin Structure Infections - A European Perspective (2008)

In a randomized, double-blind, multicenter, multinational, controlled trial, 546 patients with complicated skin and skin structure infections received tigecycline 100 mg/day (a 100-mg initial dose and then 50 mg intravenously twice daily) or the combination of vancomycin 2 g/day (1 g intravenously twice daily) and aztreonam 4 g/day (2 g intravenously twice daily) for up to 14 days. Three hundred eighty-five (385) were from Europe. The primary endpoint was the clinical response in the clinical modified intent-to-treat (c-mITT) and clinically evaluable populations at the test-of-cure visit 12 to 92 days after the last dose. The microbiologic response at the test-of-cure visit was also assessed. Safety was assessed by physical examination, laboratory results and adverse event reporting. Of the patients enrolled in Europe, 376 patients were included in the c-mITT population (tigecycline group, n = 189; vancomycin/aztreonam group, n = 187), and 326 were clinically evaluable (tigecycline group, n = 167; vancomycin/aztreonam group, n = 159). The clinical responses in the tigecycline and the vancomycin/aztreonam groups in the clinically evaluable population were 89.8% versus 95.0%. Microbiologic eradication (documented or presumed) occurred in 84.8% of the European patients receiving tigecycline and 93.2% of the European patients receiving vancomycin/aztreonam. The number of European patients reporting adverse events was similar in the two groups, with increased nausea and vomiting rates in the tigecycline group and an increased incidence of rash and increases in alanine aminotransferase and aspartate aminotransferase levels in the vancomycin/aztreonam group. Current data support findings from the overall results in the Phase 3 study and suggest that tigecycline is safe and effective for the treatment of complicated skin and skin structure infections.
Crosstalk Analysis between Interconnects in High-Speed Server Packages (2007)

This paper discusses crosstalk analysis between interconnects in high-speed server packages. Over the last decade, the scaling of the CMOS transistors has enabled the design of microprocessors operating at multi-gigahertz frequencies. For meeting the high bandwidth demands and low-power requirements, digital technologies are quickly moving to gigabit data rate and sub-voltage range signaling levels. However, this higher speed performance comes at a price, which means that signal integrity becomes a significant portion of the design effort. Especially, crosstalk analysis between interconnects in high-speed packages has become critical for design optimization of signal interconnects in system. This paper investigates importance of crosstalk analysis for IBM's high-speed server packages. For an efficient crosstalk analysis between interconnects in highspeed digital systems, an IBM's internal tool called PATS (package analysis tool suite) was used to investigate crosstalk over 1000 signal nets. The ISNRR (integral of squared noise ramp response) method has been developed to quantify crosstalk accurately and used to analyze IBM's organic modules for high-speed applications.
In vitro oxidation of 2,6-diethylaniline by rat liver microsomal enzymes (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIn vitro oxidation of 2,6-diethylaniline by rat liver microsomal enzymesPaul C. C. Feng and Stephen J. WrattenCite this: J. Agric. Food Chem. 1987, 35, 4, 491–496Publication Date (Print):July 1, 1987Publication History Published online1 May 2002Published inissue 1 July 1987https://pubs.acs.org/doi/10.1021/jf00076a012https://doi.org/10.1021/jf00076a012research-articleACS PublicationsRequest reuse permissionsArticle Views71Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
In0.53Ga0.47As metal-semiconductor-metal photodetector using proton bombarded p-type material (1991)

Metal-semiconductor-metal (MSM) photodetectors have been fabricated using as-grown and proton-bombarded p-type In0.53Ga0.47As. Proton bombardment caused a decrease in the dark current, an increase in the breakdown voltage, and an improvement in the speed of the MSM detector. The dark current of the MSM detector with 3×1015 cm−3 proton bombardment is 10 nA at 2 V and 300 nA at 5-V bias. The dc responsivity is 0.7 A/W and impulse response full width at half maximum is 160 ps for 1.3 μm radiation at 5 V bias.
The HIV Tat protein confers hypersensitivity to CD28-mediated costimulatory signals in infected T cells (1996)

info:eu-repo/semantics/published
Batch Endpoint Prediction using Local Mixture of Batch Time Experts (2022)

Some batch processes have large variability in batch-to-batch time completion, possibly because of the different process conditions and external factors. The time of batch completion is commonly inferred from process experts. However, this may lead to inaccuracies due to the uncertainty associated with the batch-to-batch variations, leading the process to run more than is needed. Process engineers could appeal to statistical process monitoring and control mechanisms to estimate the batch time completion. However, the existing tools for batch prediction rely on dynamic time warping, which is not straightforward to implement and unsuitable for estimating the remaining batch time in real-time. This work presents a new framework for remaining batch time prediction in real-time by combining local models of each batch using the mixture of local experts models. A local batch time model is learned for each batch separately and combined to predict the remaining batch time. When a new sample becomes available on real-time data, the framework detects the probabilistic similarity of the current batch sample to the historical batch data. The remaining batch time is estimated by weighting the local batch time models. This approach has been evaluated on a polymerization benchmark data set and has shown promising results. The results show that the mixture of local batch experts can predict the remaining batch time without the need for any data alignment. Thus, simplifying the process of building process monitoring control tools for the remaining batch time prediction.
A Beam-Steerable Rollable Reflectarray (2020)

This paper proposes a novel beam-steerable Reflectarray Antenna (RA) at Ku-band. This RA consists of a 58×30 square patch elements printed on a flexible plastic substrate. The RA is rolled around two cylinders to form a 30×30 RA aperture. Mechanical rotation is used to turn the two cylindrical tubes in both the left and right directions to steer the beam. The phase synthesis optimization procedure is also introduced. The obtained primary results using array theory show that the beam is able to steer from -24° to +24° in elevation with a steering step of 4° and provide a 4 dB directivity variation by mechanically rotating the RA. These results show that our proposed design is suitable for implementing high gain antennas with beam-steering capabilities that require less power. Such antennas are needed in CubeSat and space applications.
63 – Gender Differences in Hereditary Cancer Syndromes: Risks, Management, and Testing for Inherited Predisposition to Cancer (2010)

Publisher Summary Most individuals who develop cancer do not carry mutations in the inherited cancer genes. Individuals with mutations in highly penetrant genes can be clinically distinguished on the basis of their strong family history with multiple individuals in multiple generations affected with cancer, early age of onset of cancer, multiple primary cancers in a single individual, and clustering of particular types of cancer within either the individual or the family. In some cases, ethnicity also may be a predisposing factor. Although all ethnic groups have been found to carry mutations in these genes, certain ethnic groups may carry particular founder mutations at higher frequency. In addition to rare but highly penetrant monogenic (single gene) cancer susceptibility syndromes, another 5–30% of cancer is familial and likely represents the interaction of a small number of cancer susceptibility genes that in combination with each other and the environment increase the susceptibility to cancer. In families with familial rather than monogenic cancer susceptibility, the age of onset is often older and the number of affected family members is often fewer. Most highly penetrant inherited cancer susceptibility genes are autosomal dominantly inherited. Autosomal dominant conditions are characterized by a 50% chance for both males and females to inherit a mutated gene from a carrier parent; they may pass it on to their children if and only if they are carriers. Although both males and females may carry a genetic mutation, this mutation may have different disease manifestations or expression in the two genders largely because of anatomic or hormonal differences between the sexes.
Genome flux in tomato auto- and auxo-trophic cell clones cultured in different auxin/cytokinin equilibria. I. DNA multiplicity and methylation levels (1995)

An analysis of the effect of changing physiological conditions on genetic stability, in terms of epigenetic changes, such as DNA, methylation patterns, and multiplicity of repetitive DNA, was carried out on tomato cell clones grown on media supplemented with different auxin/cytokinin ratios. The effect of endogenous variation in phytohormone equilibria was also indirectly analysed through a comparison of auxotrophic or habituated (autotrophic) cell clones and the differentiated leaf tissue. The data obtained showed significant variation in methylation and multiplicity levels both between clones and between treatments, clearly suggesting a contemporary influence of exogenous hormonal treatments and of the initial/endogenous physiological state of the treated tissue on both phenomena studied.
Research on Minimum Losses Buck Converter (2012)

This paper presents minimum losses Buck converter topology,the topology of circuit using passive lossless snubber network,to achieve zero-voltage switch and zero current turn-off opening of secondary network in reverse diode current and voltage spikes can be effectively suppressed,improving efficiency and stability of converter,while broadening range of soft-switch duty cycle.The theoretical analysis is verified of correctness and feasibility by a 1 kW prototype.
Spectrometry and reactivity of the 1-hydropyrenyl anion (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSpectrometry and reactivity of the 1-hydropyrenyl anionMark A. Hempenius, Cees Erkelens, Patrick P. J. Mulder, Han Zuilhof, Wouter Heinen, Johan Lugtenburg, and Jan CornelisseCite this: J. Org. Chem. 1993, 58, 11, 3076–3084Publication Date (Print):May 1, 1993Publication History Published online1 May 2002Published inissue 1 May 1993https://pubs.acs.org/doi/10.1021/jo00063a029https://doi.org/10.1021/jo00063a029research-articleACS PublicationsRequest reuse permissionsArticle Views91Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Short-Term Discontinuation of HAART Regimens More Common in Vulnerable Patient Populations (2008)

The durability of HAART regimens is often limited by antiretroviral toxicity and nonadherence, which lead to virologic failure. We sought to determine sociodemographic and psychosocial patient factors predictive of short-term discontinuation of HAART regimens overall and stratified by the reason for discontinuation. A retrospective cohort study of the UAB 1917 Clinic Cohort evaluated short-term HAART regimen discontinuation (within 12 months of regimen initiation) between 1/1995 and 8/2004 classified as (1) gastrointestinal (GI) toxicity, (2) non-GI toxicity, (3) virologic failure or nonadherence (VF/NA), (4) loss to follow-up, and (5) other. Multivariable multinomial logistic regression models accounting for dependent observations were fit to assess the relationship between patient factors and type-specific regimen discontinuation. Among the 738 study participants, 1026 of 1852 HAART regimens (55%) were discontinued within 12 months of initiation. In multivariable analysis, discontinuation for GI toxicity was more common in patients lacking private health insurance and those with a history of intravenous (IV) drug use, whereas non-GI toxicity was more common in younger patients and females. African-American patients and those with a history of IV drug use were more likely to stop a regimen due to VF/NA. Loss to follow-up was more common in younger patients, individuals who were uninsured, and those with a history of IV drug use. Short-term discontinuation of HAART regimens is more common in vulnerable populations that bear a disproportionate burden of the U.S. HIV/AIDS epidemic. More vigilant monitoring of patient populations at higher risk of toxicity and virologic failure may allow for improved HAART regimen durability.
[Acute colectasia in patients on artificial respiration. 10 cases]. (1986)

Acute colectasia may occur in patients under mechanical ventilation. Causative factors include haemodynamic changes, potassium loss, underlying pathology (chronic respiratory failure, cirrhosis) and especially morphine-like compounds used for sedation. Analysis of the results obtained with various treatments suggests that surgery is not justified: caecal perforation is extremely rare in a previous healthy colon; any surgical procedure is hazardous in this type of patient, and colectasia frequently regresses under appropriate medical treatment, even though mechanical ventilation is pursued.
Percutaneous transthoracic ventricular puncture for diagnostic and interventional catheterization (2008)

In this small cases series, direct ventricular puncture allowed the intervention to proceed with up to 9-F sheath size. Attention to puncture site relative to intercostal vascular anatomy is warranted.
Hardware Architecture for List Successive Cancellation Decoding of Polar Codes (2014)

This brief presents a hardware architecture and algorithmic improvements for list successive cancellation (SC) decoding of polar codes. More specifically, we show how to completely avoid copying of the likelihoods, which is algorithmically the most cumbersome part of list SC decoding. The hardware architecture was synthesized for a block length of N=1024 bits and list sizes L=2, 4 using a UMC 90 nm VLSI technology. The resulting decoder can achieve a coded throughput of 181 Mb/s at a frequency of 459 MHz.
Base Monolithic Fuel: Research, Development, and Qualification Plan (2014)

The Office of Global Threat Reduction Initiative within the U.S. DOE/National Nuclear Security Administration is working to convert research reactors globally from highly enriched uranium fuel to low-enriched uranium (LEU) fuel. Of the 200 candidate research reactors, over 80 reactors have been converted using LEU fuel developed in the 1980s. Additional reactor conversions using this fuel are currently underway. However, there is a small set of high performance research reactors which require a new high density LEU fuel for conversion, including six U.S. high performance research reactors (USHPRRs). This research, development, and qualification plan provides the general approach for the USHPRR team to move the selected base monolithic LEU through to licensing and use in the intended reactors. The plan includes the latest information on the perceived requirements for licensing and use of the fuel. It also includes the methods by which data will be collected to show that these requirements have been met.
Going Beyond Traditional QA Systems: Challenges and Keys in Opinion Question Answering (2010)

The treatment of factual data has been widely studied in different areas of Nat-ural Language Processing (NLP). How-ever, processing subjective information still poses important challenges. This paper presents research aimed at assess-ing techniques that have been suggested as appropriate in the context of subjec-tive- Opinion Question Answering (OQA). We evaluate the performance of an OQA with these new components and propose methods to optimally tackle the issues encountered. We assess the impact of including additional resources and processes with the purpose of im-proving the system performance on two distinct blog datasets. The improve-ments obtained for the different combi-nation of tools are statistically signifi-cant. We thus conclude that the pro-posed approach is adequate for the OQA task, offering a good strategy to deal with opinionated questions. 1