gebhart/patrepeval huggingface dataset:
Effects of Nerve Growth Factor (NGF) in Rats with Basal Forebrain Lesions (1993)

Effects of nerve growth factor (NGF) on the basal forebrain (BF) lesion-induced amnesia in rats were investigated. When NGF infusion was begun immediately after the formation of BF lesions, NGF ameliorated amnesia in a water maze task and showed a tendency to increase choline acetyltransferase (CAT) activity in the fronto-parietal cortex. The amnesia and the decrease of CAT activity were not ameliorated when NGF infusion was begun 4 weeks after BF lesion formation. These observations suggest that NGF may act as a trophic and/or a protective factor on partially damaged cholinergic neurons and that the efficacy of NGF was influenced by the phase of neuronal damage.
Synovial Mesenchymal Stem Cells Derived From the Cotyloid Fossa Synovium Have Higher Self-renewal and Differentiation Potential Than Those From the Paralabral Synovium in the Hip Joint (2018)

Synovial cells from the cotyloid fossa synovium of patients with femoroacetabular impingement syndrome are more robust in vitro, suggesting that MSCs from this source may be strongly considered for stem cell therapy.
Lethal effects of short-wavelength visible light on insects (2014)

We investigated the lethal effects of visible light on insects by using light-emitting diodes (LEDs). The toxic effects of ultraviolet (UV) light, particularly shortwave (i.e., UVB and UVC) light, on organisms are well known. However, the effects of irradiation with visible light remain unclear, although shorter wavelengths are known to be more lethal. Irradiation with visible light is not thought to cause mortality in complex animals including insects. Here, however, we found that irradiation with short-wavelength visible (blue) light killed eggs, larvae, pupae, and adults of Drosophila melanogaster. Blue light was also lethal to mosquitoes and flour beetles, but the effective wavelength at which mortality occurred differed among the insect species. Our findings suggest that highly toxic wavelengths of visible light are species-specific in insects, and that shorter wavelengths are not always more toxic. For some animals, such as insects, blue light is more harmful than UV light.
Lignans from Acanthopanax chiisanensis having an inhibitory activity on prostaglandin E2 production (2005)

The chloroform and the ethyl acetate fractions from the roots of Acanthopanax chiisanensis exhibited the significant inhibition of TPA-induced prostaglandin E(2) (PGE(2)) production in rat peritoneal macrophages. Five lignans were isolated from the chloroform fraction and their structures were elucidated as l-sesamin, helioxanthin, savinin, taiwanin C, and 3-(3,4-dimethoxybenzyl)-2-(3,4-methylenedioxybenzyl)butyrolactone. Among the lignans tested, taiwanin C showed the most potent inhibitory activity (IC(50) = 0.12 microM) on PGE(2) production with the relative order of potency, taiwanin C >> 3-(3,4-dimethoxybenzyl)-2-(3,4-methylenedioxybenzyl)butyrolactone > savinin = helioxanthin. l-Sesamin showed no inhibitory activity at 30 microM.
Immature Teratoma of the Maxillary Sinus (2014)

Immature teratomas represent a subset of benign teratomas with immature elements that may carry a worse prognosis.
Inquiry with imagery (1999)

This paper describes an integration of geographic information systems (GIS) and multimedia technologies to transform the ways K-12 students learn about their local communities. We have augmented a digital camera with a global positioning system (GPS) and a digital compass to record its position and orientation when pictures are taken. The metadata are used to retrieve and present historical images of the photographed locations to students. Another set of tools allows them to annotate and compare these historical images to develop explanations of how and why their communities have changed over time. We describe the camera architecture and learning outcomes that we expect to see in classroom use.
Kerr lens mode locking of a diode-pumped Nd:YAG laser (1992)

We demonstrate Kerr lens mode locking of a diode-pumped Nd:YAG laser by using the gain medium as the Kerr medium and no intracavity slit. Kerr self-focusing within the Nd:YAG rod is believed to improve matching between the cavity mode and the aperture created by thermal lens aberration and thereby discriminate against lower (cw) intensities. The laser produces 8.5-ps, 100-MHz pulses with 1 W of average output power and a 35% slope efficiency. Kerr lens mode locking is initiated by slight mechanical perturbation.
Clinical Utility of the 12-Gene DCIS Score Assay: Impact on Radiotherapy Recommendations for Patients with Ductal Carcinoma In Situ (2016)

Individualized risk estimates from the DCIS Score assay provide valuable information to physicians and patients. Post-assay, in response to DCIS Score results, surgeons changed treatment recommendations more often than radiation oncologists. Further investigation is needed to better understand how such treatment changes may affect clinical outcomes.
Expert Finding Considering Dynamic Profiles and Trust in Social Networks (2019)

Recently, social network services that express individual opinions and thoughts have been significantly developed. As unreliable information is generated and shared by arbitrary users in social network services, many studies have been conducted to find users who provide reliable and professional information. In this paper, we propose an expert finding scheme to discover users who can answer users’ questions professionally in social network services. We use a dynamic profile to extract the user’s latest interest through an analysis of the user’s recent activity. To improve the accuracy of the expert finding results, we consider the user trust and response quality. We conduct a performance evaluation with the existing schemes through various experiments to verify the superiority of the proposed scheme.
Performance of Five Metagenomic Classifiers for Virus Pathogen Detection Using Respiratory Samples from a Clinical Cohort (2022)

Viral metagenomics is increasingly applied in clinical diagnostic settings for detection of pathogenic viruses. While several benchmarking studies have been published on the use of metagenomic classifiers for abundance and diversity profiling of bacterial populations, studies on the comparative performance of the classifiers for virus pathogen detection are scarce. In this study, metagenomic data sets (<i>n</i> = 88) from a clinical cohort of patients with respiratory complaints were used for comparison of the performance of five taxonomic classifiers: Centrifuge, Clark, Kaiju, Kraken2, and Genome Detective. A total of 1144 positive and negative PCR results for a total of 13 respiratory viruses were used as gold standard. Sensitivity and specificity of these classifiers ranged from 83 to 100% and 90 to 99%, respectively, and was dependent on the classification level and data pre-processing. Exclusion of human reads generally resulted in increased specificity. Normalization of read counts for genome length resulted in a minor effect on overall performance, however it negatively affected the detection of targets with read counts around detection level. Correlation of sequence read counts with PCR Ct-values varied per classifier, data pre-processing (R<sup>2</sup> range 15.1-63.4%), and per virus, with outliers up to 3 log<sub>10</sub> reads magnitude beyond the predicted read count for viruses with high sequence diversity. In this benchmarking study, sensitivity and specificity were within the ranges of use for diagnostic practice when the cut-off for defining a positive result was considered per classifier.
Correlation of structure, mobility, and morphological information in heterogeneous polymer materials by two-dimensional wideline-separation NMR spectroscopy (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCorrelation of structure, mobility, and morphological information in heterogeneous polymer materials by two-dimensional wideline-separation NMR spectroscopyK. Schmidt-Rohr, J. Clauss, and H. W. SpiessCite this: Macromolecules 1992, 25, 12, 3273–3277Publication Date (Print):June 1, 1992Publication History Published online1 May 2002Published inissue 1 June 1992https://doi.org/10.1021/ma00038a037RIGHTS & PERMISSIONSArticle Views1724Altmetric-Citations421LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (677 KB) Get e-Alerts Get e-Alerts
Sp1 downregulates proinflammatory cytokine-induced catabolic gene expression in nucleus pulposus cells (2016)

During the pathogenesis of intervertebral disc degeneration, pro‑inflammatory cytokines, including tumor necrosis factor‑α (TNF‑α), stimulate the degradation of the extracellular matrix (ECM) of intervertebral discs via the activity of catabolic enzymes including matrix metalloproteinases (MMPs), disintegrins and metalloproteinases with thrombospondin motifs (ADAMTSs), and cyclooxygenase 2 (Cox2). The transcriptional promoters of the human catabolic enzymes MMPs, ADAMTS, Cox2 and Syndecan 4 contain at least one specificity protein‑1 (Sp1) transcription factor‑binding site. The present study investigated the role of Sp1 in the regulation of the mRNA and protein expression of the aforementioned catabolic enzyme genes in nucleus pulposus cells, using reverse transcription‑quantitative polymerase chain reaction, western blot, transfection and RNA interference. The data demonstrated that Sp1 transcription factor protein expression is induced by TNF‑α and interleukin‑1β. Specific inhibitors of Sp1 DNA binding to its GC‑rich consensus site, WP631 and mithramycin A, partially suppressed TNF‑α‑induced catabolic enzyme expression and activity. Genetic inhibition of Sp1 by small interfering RNA‑mediated Sp1 knockdown partially inhibited catabolic enzyme induction by TNF‑α. In addition, Sp1 transcription factor inhibitors decreased the activity of MMP3, ADAMTS4 and ADAMTS5 promoters. Furthermore, chromatin immunoprecipitation revealed functional Sp1 binding sites at ‑577/‑567 bp within the ADAMTS4 promoter and ‑718/‑708 bp within the ADAMTS5 promoter. These results provide pharmacological and genetic evidence of the importance of Sp1 in catabolic enzyme gene regulation during TNF‑α stimulation. Thus, Sp1 may represent an effective target in reducing intervertebral disc‑associated ECM loss.
Managing syslog (2014)

Log messages are generated by operating systems and applications. These messages contain important information about the health and operation of the system. The messages are also of great significance for security management, audit-checks, and forensics in an intranet. So, a logging system that generates, relays, collects and archives log messages, must be monitored and managed just like all other components of the ICT infrastructure, to ensure that it is operating normally i.e., the logs are being collected and archived as desired. In the Internet, some progress has been made towards the standardization of the syslog protocol but, to date, the management aspect of syslog has been neglected, for all practical purposes. In this paper, we discuss the necessity and importance of monitoring and managing logging systems. We present the basic design of a Management Information Base module which will make it possible to monitor and manage a syslog system using standard management protocols. Then we discuss a prototype implementation of the MIB and demonstrate a syslog management application for managing the syslog configuration of an enterprise.
Recent Design Optimization Methods for Energy-Efficient Electric Motors and Derived Requirements for a New Improved Method—Part 1 (2018)

Energy-efficient electric motors are gathering an increased attention since they are used in electric cars or to reduce operational costs, for instance. Due to their high efficiency, permanentmagnet synchronous motors are used progressively more. However, the need to use rare-earth magnets for such high-efficiency motors is problematic not only in regard to the cost but also in socio-political and environmental aspects. Therefore, an increasing effort has to be put in finding the best design possible. The goals to achieve are, among others, to reduce the amount of rare-earth magnet material but also to increase the efficiency. In the first part of this multipart paper, characteristics of optimization problems in engineering and general methods to solve them are presented. In part two, different approaches to the design optimization problem of electric motors are highlighted. The last part will evaluate the different categories of optimization methods with respect to the criteria: degrees of freedom, computing time and the required user experience. As will be seen, there is a conflict of objectives regarding the criteria mentioned above. Requirements, which a new optimization method has to fulfil in order to solve the conflict of objectives will be presented in this last paper.
True (2000)

Arachidonic acid (AA) is the precursor for prostaglandin E2 (PGE2) synthesis and increases growth of prostate cancer cells. To further elucidate the mechanisms involved in AA-induced prostate cell growth, induction of c-fos expression by AA was investigated in a human prostate cancer cell line, PC-3. c-fos mRNA was induced shortly after addition of AA, along with a remarkable increase in PGE2 production. c-fos expression and PGE2 production induced by AA was blocked by a cyclo-oxygenase inhibitor, flurbiprofen, suggesting that PGE2 mediated c-fos induction. Protein kinase A (PKA) inhibitor H-89 abolished induction of c-fos expression by AA, and partially inhibited PGE2 production. Protein kinase C (PKC) inhibitor GF109203X had no significant effect on c-fos expression or PGE2 production. Expression of prostaglandin (EP) receptors, which mediate signal transduction from PGE2 to the cells, was examined by reverse transcription polymerase chain reaction in several human prostate cell lines. EP4 and EP2, which are coupled to the PKA signalling pathway, were expressed in all cells tested. Expression of EP1, which activates the PKC pathway, was not detected. The current study showed that induction of the immediate early gene c-fos by AA is mediated by PGE2, which activates the PKA pathway via the EP2/4 receptor in the PC-3 cells.
Versiegelung initialer Schmelzdemineralisationen mit verschiedenen\nHaftvermittlern und einem Fissurenversiegler bei unterschiedlicher\nPenetrationszeit in vitro (2018)

TITELBLATT UND INHALTSVERZEICHNIS \n \n1\n\nEINLEITUNG\n\n7 \n \n2\n\nLITERATURÜBERSICHT\n\n9 \n \n2.1.\n\nGesunder Zahnschmelz\n\n9 \n \n2.1.1.\n\nZusammensetzung\n\n9 \n \n2.1.2.\n\nHistologie\n\n9 \n \n2.2.\n\nKaries\n\n10 \n \n2.2.1.\n\nAllgemeines\n\n10 \n \n2.2.2.\n\nHistologie der Schmelzkaries\n\n11 \n \n2.2.3.\n\nEpidemiologie\n\n13 \n \n2.4.\n\nKariesdiagnostik\n\n14 \n \n2.5.\n\nTherapie der Karies\n\n16 \n \n2.5.1.\n\nKlassische Therapieformen\n\n16 \n \n2.5.2.\n\nVersiegelung kariöser Läsionen\n\n17 \n \n2.6.\n\nDentale Adhäsive und Fissurenversiegler\n\n19 \n \n2.7.\n\nPhysikalische Vorgänge bei der Penetration von Flüssigkeiten in poröse\nFestkörper\n\n21 \n \n2.7.1.\n\nGrenzflächenspannung\n\n21 \n \n2.7.2.\n\nKontaktwinkel\n\n21 \n \n2.7.3.\n\nViskosität\n\n22 \n \n2.7.4.\n\nAuswirkungen der Flüssigkeitseigenschaften auf ihr Penetrationsverhalten.\n\n22 \n \n3\n\nFRAGESTELLUNG\n\n25 \n \n4\n\nMATERIAL UND METHODE\n\n26 \n \n4.1.\n\nHerstellung der Schmelzproben\n\n26 \n \n4.2.\n\nDemineralisation der Schmelzproben\n\n27 \n \n4.3.\n\nVersiegelung der initialen Schmelzdemineralisationen\n\n27 \n \n4.4.\n\nErneute Säureexposition der Proben\n\n29 \n \n4.5.\n\nVorbereitung der Proben für die konfokalmikroskopische Untersuchung\n\n29 \n \n4.6.\n\nKonfokalmikroskopische Untersuchung.\n\n31 \n \n4.7.\n\nAuswertung der gewonnenen Bilder\n\n32 \n \n4.8.\n\nMikroradiografische Auswertung\n\n36 \n \n4.9\n\nStatistische Auswertung\n\n37 \n \n5\n\nERGEBNISSE\n\n39 \n \n5.1.\n\nQuantitative Auswertung\n\n39 \n \n5.1.1.\n\nPenetrationstiefe\n\n39 \n \n5.1.2.\n\nSauerstoffinhibitionsschicht\n\n41 \n \n5.1.3.\n\nKompaktheit der Versieglerschicht\n\n42 \n \n5.1.4.\n\nProgression der Läsionstiefe\n\n43 \n \n5.2.\n\nQualitative Auswertung\n\n45 \n \n5.3.\n\nVergleich der konfokalmikroskopischen und mikroradiografischen Auswertung\n\n48 \n \n6\n\nDISKUSSION\n\n50 \n \n6.1.\n\nDiskussion von Material und Methode\n\n50 \n \n6.1.1.\n\nBoviner Schmelz\n\n50 \n \n6.1.2.\n\nErzeugung künstlicher kariesähnlicher Läsionen\n\n51 \n \n6.1.3.\n\nBehandlung der Demineralisationen\n\n51 \n \n6.1.4.\n\nVisualisierung\n\n52 \n \n6.1.5.\n\nAuswertung\n\n53 \n \n6.2.\n\nDiskussion der Ergebnisse\n\n55 \n \n6.2.1.\n\nPenetrationstiefen\n\n55 \n \n6.2.2.\n\nSauerstoffinhibitionsschicht\n\n57 \n \n6.2.3.\n\nKompaktheit der Versieglerschicht\n\n58 \n \n6.2.4\n\nProgression der Läsionstiefe\n\n58 \n \n6.2.5\n\nVergleich der Auswertungsmethoden VIRIN und TMR\n\n60 \n \n7\n\nSCHLUSSFOLGERUNGEN\n\n63 \n \n8\n\nZUSAMMENFASSUNG\n\n64 \n \n9\n\nSUMMARY\n\n65 \n \n10\n\nLITERATURVERZEICHNIS\n\n66 \n \n11\n\nANHANG\n\n72 \n \n11.1.\n\nMaterialliste.\n\n72 \n \n11.2.\n\nErgebnisse\n\n74 \n \n11.3.\n\nDanksagung\n\n76
A Network Stability Monitoring Mechanism of Cluster-Oriented Wireless Sensor Network (2014)

In wireless sensor network (WSN), every sensor node could active dynamically. Therefore, those sensor nodes will affect the stability of network topology because of clustering and de-clustering, and continuously make reconfiguration for the clusters of wireless sensor network, all that will influence the overall function of network. It is an important issue that how to elect a cluster manager (CM) to keep the stability of network topology. In addition, large amount of events maybe flood suddenly in a local area. Such the case might raise the overload of CM, even lead CM to fail or crash and the WSN topology maybe self-organized. However, a mechanism needs to be considered that allows coping with the additional loads and can balance the workload of CM. In this study, a preventable and supportable monitor mechanism to avoid CM overload cause network unstable and to reduce load imbalance problem is proposed. Hence, it can prolong lifetime of network and raise performance of network efficiently.
Pembrolizumab expanded access program (EAP) in Spain: clinical activity. (2016)

e21029 Background: The programmed death (PD-1) inhibitor pembrolizumab has recently been approved for treatment of advanced melanoma patients (p), based on a significant improvement in terms of survival demonstrated in advanced melanoma p (phase III KEYNOTE-006 trial). We evaluated the clinical activity of pembrolizumab in melanoma p treated in 23 centers from the Spanish Melanoma Group (GEM) under the expanded access program (EAP). Methods: Patients with unresectable stage III/IV melanoma who had failed to previous treatments lines received treatment with pembrolizumab 2 mg/kg every three weeks. Results: Data were collected from 66 advanced melanoma p (46 cutaneous, 8 uveal, 7 mucosal and 4 unknown primary). Forty nine p were stage M1c (74.2%), 37 p had high LDH levels (56.1%), 26 p had ECOG 0 (39.4%) and 50 p were treated in 3-4th line (75.8% ). Median overall survival (OS) was 6.8 months (m) (CI 95% 1.8; 11.8), OS12m 41.8%. For cutaneous melanoma p, median OS was 14 m (CI 95% 4.3; 23.6), OS12m 50.5%. Three p (including one refractory to previous ipilimumab) achieved a complete response (CR), and 9 p (5 refractory to ipilimumab) achieved a partial response (PR), with an overall response rate (ORR) of 18.1%. For those p who achieved ORR, stable disease (SD) and progressive disease (PD) to pembrolizumab, OS18m was 80%, 64.6% and 7% respectively (p = 0.0001). Other significant prognostic factors for OS were LDH levels (elevated/normal NR vs 3.7 m; p = 0.00001) and ECOG PS (ECOG 0, 1 and 2; NR vs 6.8 m vs 1.1 m; p = 0.0001). There were no significant differences by sex, clinical stage, previous response to ipilimumab, BRAF status or treatment line. Two of 6 p (33%) with previous G3-4 toxicity to ipilimumab achieved a long response to pembrolizumab (18.7 m+ and 13.8 m+) without relevant adverse events. Conclusions: Although this was a heavily pretreated cohort with very advanced disease, pembrolizumab activity was confirmed, with long-term responders. Low LDH levels and ECOG 0 were significant prognostic factors for survival.
TerraSAR-X and TanDEM-X System Status and System Response to Solar Related Events (2018)

The SAR satellites TerraSAR-X and TanDEM-X are operated to acquire high-resolution SAR images for scientific and commercial applications as well as a high precision digital elevation model (DEM). In order to assure the expected quality of those products and to monitor the performance of the SAR systems, long-term system monitoring (LTSM) is performed for the critical system parameters. Stimulated by this monitoring studies are made to understand the correlation of on-board system responses with dedicated space events. This paper presents the current status of the two satellites and the results of the correlations studies.
A Semiquantitative Scale or Histologic Grading of Articular Cartilage Repair (1992)

This laboratory has developed a semiquantitative scale for grading the natural healing process of defects drilled into articular cartilage. The scale is composed of four parameters: percent filling of the defect, reconstitution of the osteochondral junction, matrix staining and cell morphology; it has a score range from 0 (best) to 14 (worst). The scale was used to evaluate the healing of defects drilled into rabbit knee articular cartilage at 2, 14, 30, 60 and 120 days after surgery. No statistically significant difference in the graded score was found between the two different defect sizes (2.7 and 1.5 mm). However, the differences in score observed between specimens from different sacrifice times were significant (p less than 0.01). Currently many investigators are manipulating cartilaginous lesions in an attempt to improve healing, and this scale will provide a means for quantitatively comparing results from control and experimental groups.