gebhart/patrepeval huggingface dataset:
The Deubiquitinating Enzyme Ataxin-3 Regulates Ciliogenesis and Phagocytosis in the Retina (2020)

Expansion of a CAG repeat in ATXN3 causes the dominant polyglutamine disease spinocerebellar ataxia type 3 (SCA3), yet the physiological role of ATXN3 remains unclear. Here, we focus on unveiling the function of Ataxin-3 (ATXN3) in the retina, a neurological organ amenable to morphological and physiological studies. Depletion of Atxn3 in zebrafish and mice causes morphological and functional retinal alterations and, more precisely, photoreceptor cilium and outer segment elongation, cone opsin mislocalization, and cone hyperexcitation. ATXN3 localizes at the basal body and axoneme of the cilium, supporting its role in regulating ciliary length. Abrogation of Atxn3 expression causes decreased levels of the regulatory protein KEAP1 in the retina and delayed phagosome maturation in the retinal pigment epithelium. We propose that ATXN3 regulates two relevant biological processes in the retina, namely, ciliogenesis and phagocytosis, by modulating microtubule polymerization and microtubule-dependent retrograde transport, thus positing ATXN3 as a causative or modifier gene in retinal/macular dystrophies.
Recombinant DNA clones constructed from immunoglobulin kappa light chain messenger RNA (1978)

Recombinant DNA clones have been generated from mouse myeloma MOPC 21 immunoglobulin kappa light chain mRNA. Complementary DNA (cDNA) synthesized on kappa light chain mRNA by reverse transcriptase was made double stranded and inserted into the bacterial plasmid vector, pMB9. Approximately 70 tetracycline-resistant transformed colonies containing kappa light chain mRNA sequences were identified by colony hybridization. Five of these recombinant clones were selected and characterized. Three clones contain both kappa light chain constant and variable region sequences. Two of these three recombinant clones have been shown to include all of the kappa light chain constant and variable region coding sequences. Another of the five selected recombinant clones contain kappa light chain constant region sequences. The remaining characterized clone appears to be derived from sequences at the 5'-end of kappa light chain mRNA, possibly extending to the terminal cap structure.
INVESTIGATIONS ON FUNGICIDES II. ARYLOXY‐ AND ARYLTHIO‐ALKANECARBOXYLIC ACIDS AND THEIR ACTIVITY AS FUNGICIDES AND SYSTEMIC FUNGICIDES (1957)

A wide range of aryloxyacetic acids and corresponding acids with alkyl groups in the side chain, their arylthio‐ analogues and the antibiotic griseofulvin have been assessed in the plate test for fungistatic effect on six fungi, and as systemic fungicides against Botrytis fabae in broad beans and Alternaria solani in tomatoes. The results indicate that in general, arylthio‐ derivatives are more fungicidal than their aryloxy‐ analogues. The systemic fungicidal performance of x‐(2‐chlorophenylthio)propionic acid in the tomato test at 1–100 p. p. m. was found to be of the same order as that shown by griseofulvin at 50–500 p. p. m. Variable results were obtained with griseofulvin in the tornato test and its performance in the bean test was consistently poor. Further evidence is presented which indicates that the protection conferred by certain compounds may not be due to activity per se .
Figure S2 from IRF1 Inhibits Antitumor Immunity through the Upregulation of PD-L1 in the Tumor Cell (2023)

&lt;p&gt;Supplementary Figure S2&lt;/p&gt;
Systematic reviews and meta-analyses for more profitable strategies in peripheral artery disease (2014)

In the peripheral arteries, a thrombus superimposed on atherosclerosis contributes to the progression of peripheral artery disease (PAD), producing intermittent claudication (IC), ischemic necrosis, and, potentially, loss of the limb. PAD with IC is often undiagnosed and, in turn, undertreated. The low percentage of diagnosis (∼30%) in this setting of PAD is of particular concern because of the potential worsening of PAD (amputation) and the high risk of adverse vascular outcomes (vascular death, coronary artery disease, stroke). A Medline literature search of the highest-quality systematic reviews and meta-analyses of randomized controlled trials documents that, due to risk of bias, imprecision, and indirectness, the overall quality of the evidence concerning diagnostic tools and antithrombotic interventions in PAD is generally low. Areas of research emerge from the information collected. Appropriate treatments for PAD patients will only derive from ad-hoc studies. Innovative imaging techniques are needed to identify PAD subjects at the highest vascular risk. Whether IC unresponsive to physical exercise and smoking cessation identifies those with a heritable predisposition to more severe vascular events deserves to be addressed. Devising ways to improve prevention of vascular events in patients with PAD implies a co-ordinated approach in vascular medicine.
Effect of cleavage of the p220 subunit of eukaryotic translation initiation factor eIF-4F on protein synthesis in vitro (1995)

Conference Article| May 01 1995 Effect of cleavage of the p220 subunit of eukaryotic translation initiation factor eIF-4F on protein synthesis in vitro T. Ohlmann; T. Ohlmann 1Biochemistry Laboratory, University of Sussex Brighton BN1 9QG, ENGLAND Search for other works by this author on: This Site PubMed Google Scholar M. Rau; M. Rau 1Biochemistry Laboratory, University of Sussex Brighton BN1 9QG, ENGLAND Search for other works by this author on: This Site PubMed Google Scholar S. Morley; S. Morley 1Biochemistry Laboratory, University of Sussex Brighton BN1 9QG, ENGLAND Search for other works by this author on: This Site PubMed Google Scholar V.M. Pain V.M. Pain 1Biochemistry Laboratory, University of Sussex Brighton BN1 9QG, ENGLAND Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1995) 23 (2): 315S. https://doi.org/10.1042/bst023315s Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation T. Ohlmann, M. Rau, S. Morley, V.M. Pain; Effect of cleavage of the p220 subunit of eukaryotic translation initiation factor eIF-4F on protein synthesis in vitro. Biochem Soc Trans 1 May 1995; 23 (2): 315S. doi: https://doi.org/10.1042/bst023315s Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1995 Biochemical Society1995 Article PDF first page preview Close Modal You do not currently have access to this content.
Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 2: Aminoglycosides/aminocyclitols: apramycin, paromomycin, neomycin and spectinomycin (2021)

The specific concentrations of apramycin, paromomycin, neomycin and spectinomycin in non-target feed for food-producing animals, below which there would not be an effect on the emergence of, and/or selection for, resistance in bacteria relevant for human and animal health, as well as the specific antimicrobial concentrations in feed which have an effect in terms of growth promotion/increased yield, were assessed by EFSA in collaboration with EMA. Details of the methodology used for this assessment, associated data gaps and uncertainties, are presented in a separate document. To address antimicrobial resistance, the Feed Antimicrobial Resistance Selection Concentration (FARSC) model developed specifically for the assessment was applied. However, due to the lack of data on the parameters required to calculate the FARSC for these antimicrobials, it was not possible to conclude the assessment until further experimental data become available. To address growth promotion, data from scientific publications obtained from an extensive literature review were used. Levels in feed that showed to have an effect on growth promotion/increased yield were reported for apramycin and neomycin, whilst for paromomycin and spectinomycin, no suitable data for the assessment were available. It was recommended to carry out studies to generate the data that are required to fill the gaps which prevented the calculation of the FARSC for these four antimicrobials.
Amino acid sequence of a novel calmodulin from Paramecium tetraurelia that contains dimethyllysine in the first domain. (1987)

A class of Paramecium behavioral mutants called pantophobiacs have a deficiency in calcium-dependent potassium efflux, and this deficiency can be corrected by the microinjection of wild-type Paramecium calmodulin (Hinrichsen, R. D., Burgess-Cassler, A., Soltvelt, B. C., Hennessey, T., and Kung, C. (1986) Science 232, 503-506). As a starting point in investigations of which features allow wild-type Paramecium calmodulin to fully restore this behavior while other calmodulins are inactive or poorly effective, we elucidated the amino acid sequence of the wild-type calmodulin. We utilized an approach that combined Edman chemistry with mass spectrometry. This approach resulted in the identification of a new post-translational modification in calmodulin: N epsilon,N epsilon-dimethyllysine at residue 13. This particular modification has not been described for calmodulins studied previously. The only other first-domain modification that has been described for any calmodulin is acetylation of the amino terminus (Watterson, D. M., Sharief, F., and Vanaman, T. C. (1980) J. Biol. Chem. 255, 962-975). These results along with analyses of pantophobiac calmodulin and calmodulin binding proteins will provide insight into calmodulin's role in a well-defined behavioral mutant.
Warthin's Tumor of the Parotid Enlarged by a Facelift Suture (2015)

Warthin's tumor is the second most common benign neoplasm of the salivary gland, consisting of epithelial and lymphoid components. It is generally asymptomatic and slowly growing. Sudden increase in its size is usually a consequence of malignant change, or inflammation.
Microstructural characterization of the transition region between scar and normal tissues in a healing medial collateral ligament (2003)

The purpose of this study was to investigate the microstructure and collagen organization in the transition region between scar and normal tissues of the medial collateral ligament (MCL) in a rat model using scanning electron microscopy (SEM). Transition region microscopy consistently demonstrated continuity of collagen fibers and fibrils from the residual portions of the transected ligament through the scar region. Bifurcations/fusions, but no anastomosis, in fibers and fibrils were observed in both normal and scar tissues. In the scar region larger diameter fibers of the normal tissue bifurcated into smaller diameter fibrils in the scar region. This connection between larger diameter and smaller diameter tissues indicates that bifurcations/fusion are likely to be the dominant way in which force is transmitted in the healing ligament.
Calibrating Freely Moving Cameras (2006)

We present a novel practical method for self-calibrating a camera which may move freely in space while changing it internal parameters by zooming. We show that point correspondences between a pair of images, and the fundamental matrix computed from these point correspondences, are sufficient to recover the internal parameters of a camera. Unlike other methods, no calibration object with known 3-D shape is required and no limitation are put on the unknown motion, as long as the camera is projective. The main contribution of this paper is development of a global linear solution which is based on the well-known Kruppa equations. We introduce a formulation different from the Huang and Faugeras constraints. The method has been extensively tested on synthetic and real data and promising results are reported.
Partial purification and characterization of a 235000Mr extracellular proteinase from Trichophyton rubrum (1994)

An extracellular proteinase has been partially purified from culture filtrates of Trichophyton rubrum by ultrafiltration, isoelectric focusing and gel filtration chromatography. The enzyme has a non-reduced molecular weight of 235,000 by substrate SDS-PAGE. It has a pH optimum of 8.5 using azocasein and azoalbumin as substrates and a pI of 3.6-3.8. The metalloproteinase inhibitors EDTA and 1,10-phenanthroline, together with the chymotrypsin inhibitor chymostatin, strongly inhibited its activity. The serine proteinase inhibitors phenylmethanesulphonyl fluoride and diisopropylfluorophosphate showed weak inhibitory activity. The proteinase exhibited broad substrate activity against azocoll, azoalbumin, azocasein, laminin and fibronectin. It exhibited weak activity against elastin and keratin. Observations on the occurrence of this proteinase together with previously described lower molecular weight proteinases suggests that the former is the first to appear in minimal medium cultures. Freeze/thaw cycling of the partially purified 235,000 M(r) proteinase was found to generate low molecular weight proteinases, particularly at 53,000, 27,000 and 25,000 M(r), indicating that the latter may originate from the larger molecule.
Tunable loaded line phase shifters for microwave applications (2011)

Summary form only given, as follows. This paper presents the design and realization of a tunable periodically loaded slot line phase shifters. The tunability is achieved by using liquid crystal (LC) as a tunable dielectric. Two prototypes are fabricated based on a printed circuit board (PCB) - LC - PCB structure for 12 GHz and a glass - LC - glass structure for 18 GHz. Measurements are performed and the figure of merits of the phase shifters are determined as 47 °/dB and 42 °/dB, respectively.
Reasoning Visual Dialogs with Structural and Partial Observations (2019)

We propose a novel model to address the task of Visual Dialog which exhibits complex dialog structures. To obtain a reasonable answer based on the current question and the dialog history, the underlying semantic dependencies between dialog entities are essential. In this paper, we explicitly formalize this task as inference in a graphical model with partially observed nodes and unknown graph structures (relations in dialog). The given dialog entities are viewed as the observed nodes. The answer to a given question is represented by a node with missing value. We first introduce an Expectation Maximization algorithm to infer both the underlying dialog structures and the missing node values (desired answers). Based on this, we proceed to propose a differentiable graph neural network (GNN) solution that approximates this process. Experiment results on the VisDial and VisDial-Q datasets show that our model outperforms comparative methods. It is also observed that our method can infer the underlying dialog structure for better dialog reasoning.
Perception de l'espace et locomotion des non-voyants par profilométrie laser : aides électroniques à la locomotion (2004)

Nous prsentons les rsultats en mobilit obtenus au quotidien par les non-voyants utilisateurs des dispositifs de profilomtrie laser. Aprs un descriptif du contexte et des prrequis ncessaires pour aboutir une utilisation performante des systmes, nous en ferons une description sommaire, puis nous aborderons la dmarche progressive d'apprentissage.
Sub-nanometer pitch calibration and data quality evaluation methodology (2008)

Average CD of CD SEM and scatterometry CD (OCD) have been adopted for advanced CD control. The advantages and disadvantages of these two CD metrologies have been well discussed. The target of CD uniformity (CDU) for advanced technology has been driven to 1 nm, i.e. about three and half the size of a silicon atom, which is 0.29 nm. In the real production environment, engineers need to face sub-nanometer (< 1 nm) CD variations and do the necessary process corrections to meet the 1-nm CDU requirement. In other words, advanced CD process control has already been in the world of atomic scale. It turns out that methodology to ensure the accuracy of sub-nanometer CD has become essential for advanced CD control. In this paper, we introduced a methodology to produce 0.25, 0.5, and 1 nm programmed pitch offsets through mask design. These offsets are attainable with current process capability. Pitch offsets instead of line/space width offsets were used because the pitch is relatively process insensitive. The pitch has already been widely used as a CD SEM magnification calibration standard, e.g. Hitachi m-scale 240-nm pitch and VLSI 100-nm pitch standards. We produced large and small pitch splits to meet different magnification linearity requirements. We also used optical CD to verify the programmed pitch offset. Using the raw spectrum of OCD, systematic pitch signal changes in 0.25-nm steps can be detected, ensuring that 0.25-nm pitch offset standards are meaningful. Interestingly, 0.25 nm is smaller than the 0.29-nm Si atom. We also used this standard wafer to do the sampling size or data quality evaluation for different CD SEM measurement methodologies, e.g. 150K by 150K or 80K by 35K magnifications that in turn dictates the sample size. Pitch sensitivity is strongly related to the sampling size and line-edge roughness (LER). For example, 0.25-nm pitch sensitivity needs a larger sampling size than those of 0.5-nm and 1- nm pitch sensitivities. By means of this standard wafer, we can easily quantify metrology quality as well as choose the right metrology and sampling size for advanced process control.
Investigation of the glucose metabolism of the embryonic and neonatal broiler chicks by injection of insulin (2013)

In contrast to most mammals, chickens have blood glucose concentrations that are twice as high as these in mammals. In addition, they develop a resistance to insulin early in life (Mc Cormick et al., 1978; Seki et al., 2001) So far, the response of insulin to elevated glucose levels in embryonic and neonatal chicks is not well documented and the aim is to explore the glucose metabolism by the injection of insulin in the embryonic and neonatal chick.
An Enhanced Handover Scheme to Provide the Robust and Efficient Inter-Beam Mobility (2015)

This letter proposes an enhanced inter-beam handover (IBH) scheme for millimeter-wave mobile communication systems. The proposed scheme adopts an inter-beam coordinated scheduling to improve the performance of the IBH which can be seriously deteriorated. In addition, the proposed scheme exploits the small-sized low layer messages to reduce the signaling overhead for the IBH by considering the main features of the IBH. Numerical results have shown that the proposed scheme can decrease the handover failure rate and reduce the signaling overhead by 78%~92% compared with the conventional scheme.
Relationship between non-destructive OCT evaluation of resins composites and bond strength in a cavity (2012)

Objectives: Formation of microgaps under the composite restorations due to polymerization stress and other causes compromise the adhesion to the dental substrate and restoration durability. However, the relationship between cavity adaptation and bond strength is not clear. In this paper, we introduce a new testing method to assess cavity adaptation by swept-source optical coherence tomography (SS-OCT) and microtensile bond strength (MTBS) in the same class-I cavity. Methods: Round class-I cavities 3 mm in diameter and 1.5 mm in depth were prepared on 10 human premolars. After application of Tokuyama Bond Force adhesive, the cavities were filled by one of the two techniques; incremental technique using Estelite Sigma Quick universal composite or flowable lining using Palfique Estelite LV with bulk filling using the universal composite. Ten serial B-scan images were obtained throughout each cavity by SS-OCT. Significant peaks in the signal intensity were detected at the bonded interface of the cavity floor and to compare the different filling techniques. The specimens were later cut into beams (0.7x0.7 mm) and tested to measure MTBS at the cavity floor. Results: Flowable lining followed by bulk filling was inferior in terms of cavity adaptation and MTBS compared to the incremental technique (p&lt;0.05, t-test). The adaptation (gap free cavity floor) and MTBS followed similar trends in both groups. Conclusion: Quantitative assessment of dental restorations by OCT can provide additional information on the performance and effectiveness of dental composites and restoration techniques. This study was supported by Global Center of Excellence, Tokyo Medical and Dental University and King Abdulaziz University.
Short communication: Circulating and milk adiponectin change differently during energy deficiency at different stages of lactation in dairy cows (2014)

Adiponectin, one of the most abundant adipokines in circulation, is known for its role in regulation of body metabolism. The aim of this study was to evaluate the effects of a negative energy balance (NEB) at 2 stages of lactation (lactational NEB at the onset of lactation and an induced NEB by feed restriction near 100 d of lactation) on circulating adiponectin concentrations. We also investigated the effect of feed restriction on adiponectin concentrations in milk and the relationships of blood and milk adiponectin with selected plasma or milk variables and with measures of body condition. Plasma adiponectin was measured in 50 multiparous Holstein dairy cows throughout 3 experimental periods [i.e., period 1=3 wk antepartum up to 12 wk postpartum, period 2=3 wk of feed restriction starting at around 100 d in milk with a control (n=25) and feed-restricted group (50% of energy requirements; n=25), and period 3=subsequent realimentation period for 8 wk]. Milk adiponectin was investigated among 21 multiparous cows at wk 2 and wk 12 of period 1 and wk 2 of period 2. Adiponectin concentrations in plasma and skim milk were measured using an in-house ELISA specific for bovine adiponectin. Major changes in circulating adiponectin concentrations were observed during the periparturient period, whereas energy deficiency during established lactation at around 100 d in milk and subsequent refeeding did not affect plasma adiponectin. Together with lower adiponectin concentrations in milk (µg/mL), the reduction in milk yield led to decreased adiponectin secretion via milk (mg/d) at the second week of feed restriction. Irrespective of time and treatment, milk adiponectin represented about 0.002% of total milk protein. Mean adiponectin concentrations in milk (0.61 ± 0.03 µg/mL) were about 92% lower than the mean plasma adiponectin concentrations (32.1 ± 1.0 µg/mL). The proportion of the steady-state plasma adiponectin pool secreted daily via milk was 2.7%. In view of the similar extent of NEB in both periods of energy deficiency, decreasing adiponectin concentrations seems important for accomplishing the adaptation to the rapidly increasing metabolic rates in early lactation, whereas the lipolytic reaction toward feed restriction-induced NEB during established lactation seems to occur largely independent of changes in circulating adiponectin.
ACTIVITY PROFILES OF ANTIMUTAGENS (1991)

The short-term tests (STT) that have been usedsuccessfully to identify mutagens and potentialcarcinogens increasingly are being used to identifyantimutagens and potential anticarcinogens.Theconcept of activity profiles,already appliedsuccessfully to the display of mutagenicity data
Towards Attosecond Measurement in Complex Molecules and the Condensed Phase (2016)

The challenge of measuring ultrafast electron dynamics will be explained. Recent progress on soft X-ray sources based upon XFELs and HHG and their appication to time resolved absorption spectroscopy and related techniques will be described.
Delta-doped imagers for UV and EUV applications (2000)

In this paper we will discuss performance of delta-doped CCDs in UV and EUV, our in-house thinning capability, bonding approaches for producing flat focal plane arrays, and in-house capabilities of directly applied antireflection coatings.