gebhart/patrepeval huggingface dataset:
Ribulose Bisphosphate-Induced, Slow Conformational Changes of Spinach Ribulose Bisphosphate Carboxylase Cause the Two Types of Inflections in the Course of Its Carboxylase Reaction1 (1991)

The cause of the inflection in the course of the carboxylase reaction and the changes in the functioning form of spinach ribulose bisphosphate carboxylase (RuBisCO) during the reaction were elucidated by relating the activity to the protein conformation of RuBisCO using a fluorescence probe, 2-p-toluidinylnaphthalene sulfonate. The activity of RuBisCO in the linear phase was 50 to 60% of that in the initial burst at 0.5 to 1.0 mM ribulose bisphosphate (RuBP) and 65 to 80% at 2 to 5 mM RuBP. The amount and the progress of the decrease in the activity during the reaction had a close relationship to a change in the protein conformation of RuBisCO. The enzyme, the substrate binding sites of which were masked beforehand with carboxyarabinitol bisphosphate, still showed a change of its protein conformation upon addition of RuBP, suggesting that RuBisCO has two (substrate and regulatory) RuBP-binding sites per RuBisCO promoter. RuBisCO required over 2 mM RuBP for binding on the regulatory sites. Both sites also bound 6-phosphogluconate. When both sites were masked with 6-phosphogluconate beforehand, the course of the subsequent carboxylase reaction was linear with time. From these results, I propose that the inflection in the course of the reaction of spinach RuBisCO is a hysteretic response of the enzyme to RuBP bound to both substrate and regulatory sites.
CAWSAC: Cost-Aware Workload Scheduling and Admission Control for Distributed Cloud Data Centers (2015)

Multiple heterogeneous applications concurrently run in distributed cloud data centers (CDCs) for better performance and lower cost. There is a highly challenging problem of how to minimize the total cost of a CDCs provider in a market where the bandwidth and energy cost show geographical diversity. To solve the problem, this paper first proposes a revenue-based workload admission control method to judiciously admit requests by considering factors including priority, revenue and the expected response time. Then, this paper presents a cost-aware workload scheduling method to jointly optimize the number of active servers in each CDC, and the selection of Internet service providers for the CDCs provider. Finally, trace-driven simulation results demonstrate that the proposed methods can greatly reduce the total cost and increase the throughput of the CDCs provider in comparison to existing methods. Note to Practitioners-A cloud provider deploys its applications in geographically distributed CDCs to improve stability and reliability. For cost and performance, each CDC provides services through multiple ISPs that deliver traffic between millions of users and the CDCs provider. The geographical diversity of the bandwidth and energy cost brings the CDCs provider a big challenge of how to minimize the bandwidth and energy cost of the CDCs provider. This paper first proposes a revenue-based workload admission control method to selectively admit requests. Then, this paper proposes a cost-aware workload scheduling method to allocate requests among multiple available Internet service providers connecting to distributed CDCs. The scheduling strategy can intelligently dispatch requests, and achieve lower cost and higher throughput for the CDCs provider.
Abstract B128: A phase IB study of the MEK inhibitor GSK1120212 combined with everolimus in patients with solid tumors: Interim results. (2011)

Abstract Background: GSK1120212 (MEK) is a reversible, highly selective allosteric inhibitor of MEK1/MEK2. MEK was combined with everolimus (EVE), an mTOR inhibitor, to provide simultaneous inhibition of the MAPK and PI3K/mTOR pathways. This Phase I escalation study evaluated the safety, tolerability, pharmacokinetics (PK), and anti-tumor activity of MEK+EVE and assessed the recommended Phase II regimen (RP2R). Materials and Methods: Advanced solid tumor patients (pts) with adequate end-organ function received MEK (0.5–2mg) orally once daily (QD). EVE (5–7.5mg) was given orally with various schedules (QD, QOD, 5/7D, or 7/14D). Results: Sixty-seven pts (21 pancreatic, 14 colorectal, 6 melanoma, 4 breast, 3 neuroendocrine and 19 other cancers) received ≥ 1 dose of MEK + EVE. Cohorts 4A and 5 exceeded the maximum tolerated dose. Dose-limiting toxicities (DLTs) were G3 mucositisa (n=5), G4 thrombocytopenia (n=1), G3 acneiform rash/fatigue/dehydration (n=1) and G3 hypokalemia secondary to diarrhea. All DLTs were reversible. 2 pts had fatal serious adverse events (pneumonia, GI hemorrhage); both considered unrelated to study drugs. The most common adverse events (AEs) (≥ 25%) were mucositisa (67%), skin-related toxicities (66%), fatigue (60%), diarrhea (45%), nausea (40%), vomiting (37%), pyrexia (30%) and decreased appetite (28%). G3/G4 AEs included mucositisa (12% G3), AST elevation (10% G3) and hyperglycemia (7% G3). Mucositisa led to dose interruptions, reductions, and discontinuations in 27%, 9%, and 1% of pts, respectively. There was no PK interaction when MEK was coadministered with EVE, and PK results were consistent with previous reports when either agent was administered alone. There did not appear to be a relationship between EVE or MEK exposure and mucositisa incidence or severity. 62 pts had measurable disease at baseline and 5 achieved a partial response: 3 confirmed (1 adenoid cystic carcinoma, on-going &amp;gt;13 months; 1 squamous cell lung, 6 months, withdrawn due to co-morbidity; 1 melanoma, 6 months), and 2 unconfirmed (1 laryngeal, 1 pancreatic cancer). 18 pts had stable disease with median duration on study treatment of 18.5 (range: 5.9–52.9) weeks. Conclusion: Despite evidence of clinical activity in this heavily pretreated patient population, the toxicity profiles limit the ability to give MEK+EVE. Although multiple dosing schedules were explored, an RP2R was not identified. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2011 Nov 12-16; San Francisco, CA. Philadelphia (PA): AACR; Mol Cancer Ther 2011;10(11 Suppl):Abstract nr B128.
Redox-Switchable Hydroelementation of a Cobalt Complex Supported by a Ferrocene-Based Ligand (2016)

The first crystallographically characterized tetrahedral cobalt salen (salen = N,N′-ethylenesalicylimine) complex was synthesized by using a 1,1′-ferrocene derivative, salfen (salfen = 1,1′- di(2,4-di-tert-butyl-6-salicylimine)ferrocene). The complex undergoes two oxidation events at low potentials, which were assigned as ligand centered by comparison to the corresponding zinc complex. The cobalt complex was found to catalyze the hydroalkoxylation of styrenes, similarly to related square planar cobalt salen complexes, likely due to its fluxional behavior in alcoholic solvents. Furthermore, the one-electron-oxidized species was found to be inactive toward hydroalkoxylation. Thus, the hydroalkoxylation reactivity could be turned on/off in situ by redox chemistry.
All-optical forward-viewing photoacoustic remote sensing endoscope for high resolution label-free vascular imaging in vivo (2022)

This work involves the development of a novel endoscope based on Photoacoustic Remote Sensing (PARS), for label-free in vivo imaging of microvasculature. The PARS endoscopy is realized by raster-scanning the proximal end of a coherent, image-guide fiber bundle containing 30,000 cores arranged within a 600-µm diameter image-circle. A graded-index (GRIN) distal-end objective lens is used to focus and collect the reflected probe beam. Based on preliminary results, the endoscope is measured to have a resolution of less than 3-µm. The developed PARS endoscope is characterized using phantoms and validated for in vivo application using a live chicken embryo model.
The effects of steel mutation on testicular germ cell differentiation (1980)

The effects of artificial cryptorchidism and its surgical reversal on spermatogenesis were examined in germ cell mutant, S1/+ and wild type, +/+, mice. In cryptorchid testes no difference was found between S1/+ and +/+ mice in the number of undifferentiated type A spermatogonia. The activity of type A spermatogonia in mutant mice appeared normal as judged by its mitotic cell number and DNA synthesis. The surgical reversal of cryptorchidism resulted in regenerative differentiation of mature germ cells in both types of mice, but the pattern of cellular differentiation in the mutant testes was completely different from that of the wild type testes. At two steps of cellular differentiation, intermediate or type B spermatogonia and spermatid, the numbers of cells were much smaller in the S1/+ testes than those in the +/+ testes. The steel gene was therefore suggested to exert its effects on the differentiation of type A spermatogonia to intermediate or type B spermatogonia, on meiotic division and/or the survival rate of these cells, but not on the undifferentiated type A spermatogonia or stem cells.
Direct micro-patterning of TTF-based organic conductors on flexible substrates (2006)

We describe a new facile chemistry-based technique for patterning films of organic conductors on a polymeric substrate that consists of directly writing on the organic conducting surface using a local heat source such as a laser beam.
APLICACIONES ERGONOMICAS PARA LA MEJORIA DEL RENDIMIENTO DE LOS BRIGADISTAS DE INCENDIOS FORESTALES (2003)

The present study was part of project sponsored by a state agency called FONDED, with the participation of five large forest companies. The main objective was to determine the human response during forest fire fighting, with the aim to contribute with knowledge, helping to organise fire control safely\nand efficiently.\nTo fulfil the specific objectives, studies were carried out during real fires and also during the\nconstruction of fire lines. In fires, the physiological response to physical work and heat, was measured\nwith continuous recordings of cardiac frequency. Dry, wet and globe temperature were registered, as well\nas the slope of the ground, the characteristics of the fuel, the stage of the fire, the quality of the line and\noutput in workers fighting fires in 605 occasions. On the other hand, the studies during fire line construction\nwere carried out to establish, under controlled conditions, the effect of rest pauses on fire fighters response. The main conclusion is that forest fire control is a very heavy work. Therefore, when the\nconditions for fighting a fire are more complex and also when the time for control increases, the physiological\ndemands can be extremely high, leading the workers to fatigue. The consequence is a reduction in the\nquantity and quality of the work they do. Criteria for selection, training, as well as organisational measures\nduring fire fighting to reduce these effects are discussed. It is concluded that the multidisciplinary approach\nof Ergonomics, can be a useful tool for work organisation, providing knowledge to engineers, technicians\nand managers of the human capacities, needs and limitations to be used in work system design. It is\nexpected that the application of this knowledge will reduce the risks for fire fighters as well the economic impact of forest fires.
INTRODUCTORY REMARKS (2014)

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Determination of DNA sequences essential for FLP-mediated recombination by a novel method. (1985)

The yeast 2-micron circle plasmid encodes a protein, FLP, that mediates site-specific recombination across the two FLP-binding sites of the plasmid. We have used a novel technique, "exonuclease-treated substrate analysis," to determine the minimal duplex DNA sequence needed for this recombination event. A linear DNA containing two FLP sites in a direct orientation was treated with the double-strand specific 3'-exonuclease, exonuclease III, to generate molecules with a nested set of single-strand deletions that extended into one of the FLP sites. The DNA was then end-labeled at the sites of the deletions and used as a substrate for recombination in vitro. FLP-mediated recombination between two FLP sites excised a restriction endonuclease cleavage site from the DNA. Comparison of the fragments produced by restriction enzyme digestion of untreated and FLP-treated DNA showed to the nucleotide the duplex DNA sequence required for FLP-mediated recombination. To examine essential sequences in the opposite DNA strand, similar experiments were done using the 5'-exonuclease encoded by phage T7. The minimal essential duplex DNA sequence lies within the region of the FLP site that was previously shown to be protected from nuclease digestion in the presence of FLP. A modified form of this technique can be used to study the minimal sequence requirements of site-specific DNA binding proteins.
Amino Acid Residues That Confer High Selectivity of the α6 Nicotinic Acetylcholine Receptor Subunit to α-Conotoxin MII[S4A,E11A,L15A] (2008)

Nicotinic acetylcholine receptors (nAChRs) containing alpha3 and beta2 subunits are found in autonomic ganglia and mediate ganglionic transmission. The closely related alpha6 nAChR subtype is found in the central nervous system where changes in its level of expression are observed in Parkinson's disease. To obtain a ligand that discriminates between these two receptors, we designed and synthesized a novel analog ofalpha-conotoxin MII, MII[S4A,E11A,L15A], and tested it on nAChRs expressed in Xenopus oocytes. The peptide blocked chimeric alpha6/alpha3beta2beta3 nAChRs with an IC(50) of 1.2 nm; in contrast, its IC(50) on the closely related alpha3beta2 as well as non-alpha6 nAChRs was three orders of magnitude higher. We identified the residues in the receptors that are responsible for their differential sensitivity to the peptide. We constructed chimeras with increasingly longer fragments of the N-terminal ligand binding domain of the alpha3 subunit inserted into the homologous positions of the alpha6 subunit, and these were used to determine that the region downstream of the first 140 amino acids was involved. Further mutagenesis of this region revealed that the alpha6 subunit residues Glu-152, Asp-184, and Thr-195 were critical, and replacement of these three residues with their homologs from the alpha3 subunit increased the IC(50) of the peptide by >1000-fold. Conversely, when these key residues inalpha3 were replaced with those fromalpha6, the IC(50) decreased by almost 150-fold. Similar effects were seen with other alpha6-selective conotoxins, suggesting the general importance of thesealpha6 residues in conferring selective binding.
Proof of Concept of a Novel Hybrid Wind-Wave Energy Converter (2018)

In a global scenario of climate change and raising threats to the marine environment, a sustainable exploitation of offshore wind and wave energy resources is not only crucial for the consolidation of both industries, but also to provide a reliable and accessible source of renewable energy. In this context, and with the shared challenge for both industries to reduce costs, the combination of wind and wave technologies has emerged. In particular, this research deals with a novel hybrid system that integrates an oscillating water column, wave energy converter, with an offshore wind turbine substructure. In this paper, the novel hybrid wind-wave energy converter is studied in a three steps process. First, assessing a preliminary concept by means of a concept development methodology for hybrid wind-wave energy converters. Secondly, an OWC WEC sub-system is defined, on the basis of the results from the first step. Finally, the proof of concept of the WEC sub-system is carried out by means of a physical modelling test campaign at the University of Plymouth’s COAST laboratory.
Awareness about proper use of sunscreen in people of color: A Jordanian‐based survey (2019)

The use of sunscreen is inadequate in this population of color (POC). Lack of proper counseling, failure to read use instructions can contibute to inadequate use of sunscreen. Risks and benefits of sunscreen should be explained by medical professionals. The media should be more utilized to disseminate such knowledge.
High CD34+ Cell Counts Decrease Hematologic Toxicity of Autologous Peripheral Blood Progenitor Cell Transplantation (1998)

Optimal numbers of CD34+ cells to be reinfused in patients undergoing peripheral blood progenitor cell (PBPC) transplantation after high-dose chemotherapy are still unknown. Hematologic reconstitution of 168 transplantations performed in patients with lymphoproliferative diseases was analyzed according to the number of CD34+ cells reinfused. The number of days from PBPC reinfusion until neutrophil recovery (&gt;1.0 × 109/L) and unsustained platelet recovery (&gt;50 × 109/L) were analyzed in three groups defined by the number of CD34+ cells reinfused: a low group with less than or equal to 2.5 × 106 CD34+ cells/kg, a high group with greater than 15 × 106 CD34+cells/kg, and an intermediate group to which the former two groups were compared. The 22 low-group patients had a significantly delayed neutrophil (P &lt; .0001) and platelet recovery (P &lt; .0001). The 41 high-group patients experienced significantly shorter engraftment compared with the intermediate group with a median of 11 (range, 8 to 16) versus 12 (range, 7 to 17) days for neutrophil recovery (P = .003), and a median of 11 (range, 7 to 24) versus 14 (range, 8 to 180+) days for platelet recovery (P&lt; .0001). These patients required significantly less platelet transfusions (P = .002). In a multivariate analysis, the amount of CD34+ cells reinfused was the only variable showing significance for neutrophil and platelet recovery. High-group patients had a shorter hospital stay (P = .01) and tended to need fewer days of antibotic administration (P = .12). In conclusion, these results suggest that reinfusion of greater than 15 × 106 CD34+ cells/kg after high-dose chemotherapy for lymphoproliferative diseases further shortens hematopoietic reconstitution, reduces platelet requirements, and may improve patients' quality of life.
The SIMBAD astronomical database (2000)

Simbad is the reference database for identification and bibliography of astronomical objects. It contains identifications, “basic data”, bibliography, and selected observational measurements for several million astronomical objects. Simbad is developed and maintained by CDS, Strasbourg. Building the database contents is achieved with the help of several contributing institutes. Scanning the bibliography is the result of the collaboration of CDS with bibliographers in Observatoire de Paris (DASGAL), Institut d'Astrophysique de Paris, and Observatoire de Bordeaux. When selecting catalogues and tables for inclusion, priority is given to optimal multi-wavelength coverage of the database, and to support of research developments linked to large projects. In parallel, the systematic scanning of the bibliography reflects the diversity and general trends of astronomical research. A WWW interface to Simbad is available at: http://simbad.u-strasbg.fr/Simbad.
Enhancing the Gain by Quantum Coherence in Terahertz Quantum Cascade Lasers (2014)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text E. Strupiechonski, R. Blanchard, P. Genevet, Y. Wang, A. Belyanin, L. H. Li, E. H. Linfield, A. G. Davies, F. Capasso, and M. O. Scully, "Enhancing the Gain by Quantum Coherence in Terahertz Quantum Cascade Lasers," in CLEO: 2014, OSA Technical Digest (online) (Optica Publishing Group, 2014), paper FTu3D.1. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Pt–CeO2nanoporous spheres – an excellent catalyst for partial oxidation of methane: effect of the bimodal pore structure (2017)

Bimodal pore size distribution played the most important role for the catalyst's superior activity during POM.
Postherpetic neuralgia: Are C-nociceptors involved in signalling and maintenance of tactile allodynia? (1993)

Under normal conditions acute stimulation and sensitization of polymodal nociceptive C-fibres cause pain and, due to afferent axon reflex activation, a local skin vasodilatation, flare reaction and skin temperature increase. Two questions arise: (i) Do sensitized C-nociceptors signal allodynia in chronic postherpetic neuralgia? (ii) If not, does ongoing peripheral nociceptive C-fibre input maintain a central process that accounts for allodynia? Ten patients with postherpetic neuralgia and tactile allodynia and 10 control subjects were studied using a laser Doppler perfusion monitor. Peripheral nociceptive C-fibre function was assessed by quantitative measurement of the axon reflex vasodilatation and flare reaction induced by histamine iontophoresis and compared with non-neural vasodilatation induced by local skin heating. Resting skin temperature, skin resistance and resting skin blood flow were the same in the allodynic area and the contralateral homologous skin area. The histamine responses (vasodilatation and flare) were significantly reduced or nearly abolished in the allodynic area compared with the contralateral side, whereas the temperature-dependent vasodilatation in patients and the histamine responses in healthy controls showed no side differences. C-fibre mediated pain and itch sensations were also decreased in the allodynic area. These findings indicate a considerable impairment of cutaneous nociceptive C-fibre function in the allodynic area. Allodynic stimuli of 20 s did not cause any local blood flow change. Impairment of C-fibre function was positively correlated with intensity of neuropathic pain. We conclude that sensitized nociceptive C-fibres are not involved in signalling allodynia. Changes in CNS processing may occur after zoster infection that strengthen the synaptic ties between central pain signalling pathways and low-threshold mechanoreceptors with A beta-fibres. This altered central processing is not maintained by ongoing cutaneous nociceptive C-fibre input, at least in some patients with postherpetic neuralgia. On the contrary, an anatomical synaptic reorganization depending on afferent C-fibre degeneration seems to be more likely, particularly in advanced stages of postherpetic neuralgia.
Notch bandwidth and filter order trade-offs in band-notched monopole antennas for UWB applications (2008)

In this work, we addressed the problem of local oscillator leakage from the mixer in our UWB localization system. The leakage could be remedied either by using an integrated filter or using a band-notched antenna. Here we have utilized a band notched antenna and analyzed the effects of the filter order on the pulse amplitude and delay spread. It was found that the filter order and rejection bandwidth could be optimized to satisfy the specific amplitude and pulse spread requirements. Four UWB monopole antennas were designed, fabricated and measured. The measurement results were in good agreement with the simulation results. We showed that using a higher order filter allows for adequate rejection bandwidth and higher rejection levels while keeping the first pulse amplitude almost constant, but the power delay spread increases accordingly.
Improvement in radar detection through window processing in the Hough space (2008)

The subject of this paper is estimation of straight-line parameters noisy edge points using the Polar Hough transform. We propose a new detection algorithm in Hough space that will increase detection probability when the target coordinates are measured with errors. We compare the accuracy of the method with result from polar Hough transform when the target coordinates are measured with out errors. The influence of trajectory parameters accuracy on the quality of work of TBD multi-radar system is estimated.