gebhart/patrepeval huggingface dataset:
Efficiency Enhancement of All‐Solution‐Processed Inverted‐Structure Green Quantum Dot Light‐Emitting Diodes Via Partial Ligand Exchange with Thiophenol Derivatives Having Negative Dipole Moment (2019)

Abstract Thiophenol derivatives having a negative dipole moment such as thiophenol (TP), 4‐methylthiophenol (4‐MTP), and 4‐(dimethylamino)thiophenol (4‐DMATP) are incorporated into quantum dots (QDs) and the efficiency of all‐solution‐processed inverted‐structure quantum dot light‐emitting diodes (QLEDs) is enhanced. The negative dipole moments of TP, 4‐MTP, and 4‐DMATP are attributed to the enhancement of the efficiency of the QLEDs. The valence band maximum (VBM) of the QDs is upshifted, and the energy gap between the VBM and the highest molecular orbital level of the hole transport layer is reduced to −0.16 from 0.46 eV by the negative dipole moment of thiophenol derivatives. The electron and hole transport of the QDs are accelerated, and charge balance is achieved at 5 V with a reduction of 1.25 V by the thiophenol derivatives. The QLEDs with 4‐DMATP exhibit a maximum luminance of 106 400 cd m −2 , a maximum current efficiency of 98.2 cd A −1 , and an external quantum efficiency (EQE) of 24.8%. The EQE of 24.8% is the highest value reported thus far for all‐solution‐processed inverted‐structure single‐device QLEDs, to the best of knowledge. Improvement by factors of 2.99, 1.57, and 1.54 are achieved in the maximum luminescence, maximum current efficiency, and EQE respectively, compared with a QLED with OA ligands.
ChemInform Abstract: INTERACTION OF (PT2CL4(PPR3)2) WITH SOME SIMPLE ORGANIC MOLECULES (1980)

Abstract Mittels Tieftemp.
Reaction Mechanism of Phenolic Lignin and High Concentration Chlorine Dioxide and Its Application (2020)

In fact, the chemical reaction rate of traditional chlorine dioxide bleaching of pulp is too fast to observe the intermediate process. The mechanism behind the reaction of 4-hydroxy-3-methoxyacetophenone (APO), a phenolic lignin model compound, with high concentrations of chlorine dioxide was investigated. Individual solutions of each compound and a mixture of the two were analyzed by UV-vis spectrophotometry, and an absorbance band at 260 nm was observed for the stable benzoquinone intermediates at room temperature. Free chlorine dioxide displayed an absorbance at 360 nm and changes in this absorbance were studied with different APO concentrations. A fixed molar ratio of 1:3 was obtained between APO and chlorine dioxide consumption. The intermediate absorbance demonstrated a linear relationship with the APO concentration. The reaction path between APO and chlorine dioxide at high concentrations was speculated, and it was observed that the activity of C1, C2, C3, C5, and C6 on the APO benzene ring was enhanced when high concentrations of chlorine dioxide were present. From these results, a new method for efficient and clean chlorine dioxide bleaching can be developed.
ChemInform Abstract: PEROXYDERIVATE VON ADAMANTAN, SYNTH. UND RK. VON 1‐TERT.‐BUTYLPEROXYCARBONYL‐ADAMANTAN (1970)

Abstract Das Säurechlorid (I) (aus Adamantan‐1‐carbonsäure und Thionylchlorid mit 99,5% Ausbeute dargestellt) wurde in trockenem n‐Hexan mit dem Hydroperoxid (II) zum Perester (III) (Ausbeute 89%) umgesetzt.
Annexin1 regulates DC efferocytosis and cross-presentation during Mycobacterium tuberculosis infection (2014)

The phagocytosis of apoptotic cells and associated vesicles (efferocytosis) by DCs is an important mechanism for both self tolerance and host defense. Although some of the engulfment ligands involved in efferocytosis have been identified and studied in vitro, the contributions of these ligands in vivo remain ill defined. Here, we determined that during Mycobacterium tuberculosis (Mtb) infection, the engulfment ligand annexin1 is an important mediator in DC cross-presentation that increases efferocytosis in DCs and intrinsically enhances the capacity of the DC antigen-presenting machinery. Annexin1-deficient mice were highly susceptible to Mtb infection and showed an impaired Mtb antigen-specific CD8+ T cell response. Importantly, annexin1 expression was greatly downregulated in Mtb-infected human blood monocyte-derived DCs, indicating that reduction of annexin1 is a critical mechanism for immune evasion by Mtb. Collectively, these data indicate that annexin1 is essential in immunity to Mtb infection and mediates the power of DC efferocytosis and cross-presentation.
Optimal transmission for the MIMO bidirectional broadcast channel in the wideband regime (2011)

This paper presents an optimal transmit strategy for multiple antennas bidirectional broadcast channels in the wideband regime. The transmit covariance matrix at the relay has been designed in order to maximize the wideband weighted sum rate. A closed form of the optimal matrix is derived, which shows that a single beam transmit strategy is optimal. The transmit strategies for some special cases, the wideband capacity region, and the minimum energy per bit versus fairness issues are also discussed.
A study on ice crystals in frozen meat : a thesis presented in partial fulfilment of the requirements for the degree Master of Technology in Food Technology at Massey University (1969)

In 1924 in a paper delivered to the Fourth International Congress of Refrigeration T. Moran (1924) stated, "Probably nothing is more needed by the refrigerating industry than an adequate theory of the freezing of tissues, because on it must be based any important advance in practical procedure other than such as one of a purely engineering nature." Addressing an advanced study institute held at the University of Strathclyde in September 1966 H.N. Symons said, "Important though it is technology occupies a relatively minor position in the structure of the frozen food industry." [From Introduction]
Internalization of targeted microbubbles by endothelial cells and drug delivery by pores and tunnels (2022)

Ultrasound insonification of microbubbles can locally enhance drug delivery by increasing the cell membrane permeability. To aid development of a safe and effective therapeutic microbubble, more insight into the microbubble-cell interaction is needed. In this in vitro study we aimed to investigate the initial 3D morphology of the endothelial cell membrane adjacent to individual microbubbles (n = 301), determine whether this morphology was affected upon binding and by the type of ligand on the microbubble, and study its influence on microbubble oscillation and the drug delivery outcome. High-resolution 3D confocal microscopy revealed that targeted microbubbles were internalized by endothelial cells, while this was not the case for non-targeted or IgG1-κ control microbubbles. The extent of internalization was ligand-dependent, since α<sub>v</sub>β<sub>3</sub>-targeted microbubbles were significantly more internalized than CD31-targeted microbubbles. Ultra-high-speed imaging (~17 Mfps) in combination with high-resolution confocal microscopy (n = 246) showed that microbubble internalization resulted in a damped microbubble oscillation upon ultrasound insonification (2 MHz, 200 kPa peak negative pressure, 10 cycles). Despite damped oscillation, the cell's susceptibility to sonoporation (as indicated by PI uptake) was increased for internalized microbubbles. Monitoring cell membrane integrity (n = 230) showed the formation of either a pore, for intracellular delivery, or a tunnel (i.e. transcellular perforation), for transcellular delivery. Internalized microbubbles caused fewer transcellular perforations and smaller pore areas than non-internalized microbubbles. In conclusion, studying microbubble-mediated drug delivery using a state-of-the-art imaging system revealed receptor-mediated microbubble internalization and its effect on microbubble oscillation and resulting membrane perforation by pores and tunnels.
Intestinal transit of an orally administered streptomycin-rifampicin-resistant variant ofBifidobacterium longumSBT2928: its long-term survival and effect on the intestinal microflora and metabolism (2001)

It is clarified that BL2928SR has the ability for long-term survival in the human gastrointestinal tract, and alters the composition and metabolism of the intestinal microflora.
Elaboration de latex nanostructurés à base de poly(chlorure de vinylidène) par polymérisation en émulsion (2012)

Of 25 simultaneous pancreas-kidney transplant (SPK) recipients treated with thymoglobulin induction, sirolimus and reduced-dose cyclosporine (CsA), 18 low-immune responders (non-African-Americans, PRA < 30%) were withdrawn from prednisone on post-transplant day 5, whereas seven high-immune responders continued on prednisone. Most high- and low-immune responder recipients were converted from CsA to mycophenolic acid (MPA) at six months post-transplantation. At a mean follow-up of 28 +/- 10 months, two pancreas grafts were lost to pancreatitis. There were no patient or kidney graft losses, but one acute rejection episode. At 28 +/- 11 months, all 18 low-responder recipients remain steroid-free. Twenty recipients (14 low and six high-immune responders) were converted from CsA to MPA. During conversion, immune response was monitored by Flow-PRA and T-cell stimulation (Cylex) assays. Nineteen of 20 recipients displayed a post-conversion PRA of 0%, whereas one highly sensitized patient expressed a post-conversion PRA of 67%. Fifty-eight percent of individual T-cell stimulation scores were in the hypo-responsive range. Twelve of 18 low-immune responders are both steroid and CsA-free at a mean follow-up of 17 +/- 13 months, whereas five of seven high-immune responders remain CsA-free at a mean follow-up of 11 +/- 10 months. These data suggest that thymoglobulin induction with combined sirolimus and CsA maintenance therapy permits immunosuppression minimization in selected SPK recipients.
Conjugates Containing Two and Three Trithiolato-Bridged Dinuclear Ruthenium(II)-Arene Units as In Vitro Antiparasitic and Anticancer Agents (2020)

The synthesis, characterization, and in vitro antiparasitic and anticancer activity evaluation of new conjugates containing two and three dinuclear trithiolato-bridged ruthenium(II)-arene units are presented. Antiparasitic activity was evaluated using transgenic <i>Toxoplasma</i><i>gondii</i> tachyzoites constitutively expressing β-galactosidase grown in human foreskin fibroblasts (HFF). The compounds inhibited <i>T.</i><i>gondii</i> proliferation with IC<sub>50</sub> values ranging from 90 to 539 nM, and seven derivatives displayed IC<sub>50</sub> values lower than the reference compound pyrimethamine, which is currently used for treatment of toxoplasmosis. Overall, compound flexibility and size impacted on the anti-<i>Toxoplasma</i> activity. The anticancer activity of 14 compounds was assessed against cancer cell lines A2780, A2780cisR (human ovarian cisplatin sensitive and resistant), A24, (D-)A24cisPt8.0 (human lung adenocarcinoma cells wild type and cisPt resistant subline). The compounds displayed IC<sub>50</sub> values ranging from 23 to 650 nM. In A2780cisR, A24 and (D-)A24cisPt8.0 cells, all compounds were considerably more cytotoxic than cisplatin, with IC<sub>50</sub> values lower by two orders of magnitude. Irrespective of the nature of the connectors (alkyl/aryl) or the numbers of the di-ruthenium units (two/three), ester conjugates <b>6</b>-<b>10</b> and <b>20</b> exhibited similar antiproliferative profiles, and were more cytotoxic than amide analogues <b>11</b>-<b>14</b>, <b>23,</b> and <b>24</b>. Polynuclear conjugates with multiple trithiolato-bridged di-ruthenium(II)-arene moieties deserve further investigation.
Abgrenzung des ausnutzbaren Kennlinienbereichs (1965)

Die Kennlinienfelder sind eine der Diskussionsgrundlagen für die Anwendung des Transistors namentlich bei großer Aussteuerung; sie geben in Verbindung mit einigen besonderen physikalischen Effekten die Aussteuerungsgrenzen an. Da die größten Amplituden kollektorseitig im Betriebsbereich aktiv normal auftreten, bestimmt das Kollektorkennlinienfeld meist allein die Einsatzgrenzen, wenn nicht andere Grenzwerte, wie z. B. bei Drifttransistoren die maximale Basis-Emitter-Spannung U BE , überschritten werden (Bild 11.1).
Mechanism of Perfluoropolyether Chains Bonding on Carbon Overcoat Surface by Ultraviolet Irradiation (2009)

To elucidate the bonding mechanism of a non-polar perfluoropolyether lubricant (PFPE lube) under ultraviolet (UV) irradiation, the UV wavelength ranges in which photoelectrons emanate were identified using photoelectron spectroscopy in air (PESA), and the bonding behavior of the lube at various UV wavelengths was studied. The results showed that photoelectrons emanated from magnetic disk substrates at wavelengths of 240 nm or less and the lube was bonded to the substrate in the wavelength range where photoelectrons were emanated. For comparison, Si, SiO2/Si, and Si3N4/Si were also used as substrate; the Si substrate which emanated the highest photoelectron intensity showed the highest bonded ratio of the lube. The lube, however, also bonded to the SiO2/Si and Si3N4/Si substrates under UV irradiation at 222 nm, where photoelectrons do not emanate from the substrates. These observations suggest that the bonding mechanism between the PFPE chains and the carbon overcoat (COC) surfaces under UV irradiation was affected by factors other than photoelectrons.
Fundamental Studies on One-Dimensional Cannonball Targets at 10.6 µm Laser Wavelength (1985)

A new scheme for the inertial confinment fusion (ICF) pellet, called a Cannonball target, has been investigated experimentally using a 10.6 µm laser. The fuel pellet is surrounded by a tamper with a vacuum between the two, and the laser energy is introduced into this space through a small hole in the tamper. The fundamental properties of the Cannon-ball target, such as its absorption and hydrodynamics, and the emission spectra of ions and electrons, have been investigated. The results show a good absorption of 50% and a high hydrodynamic efficiency of 16%. It was found possible to suppress hot-electron preheating.
Cerebral Microbleeds After Use of Extracorporeal Membrane Oxygenation in Children (2012)

Cerebral microbleeds (CMB) on gradient-recalled echo (GRE) magnetic resonance imaging (MRI) are rarely seen in children, yet have been described following vascular procedures in adults. Extracorporeal membrane oxygenation (ECMO) has been associated with vascular injury and neurological events in children, but there have been no reports to date of GRE MRI findings in children treated with ECMO. We reviewed MRI scans for all vascular neurology consultations in children treated with ECMO at an academic medical center over a 5-year period. In 6 of 12 cases, GRE was acquired as others were unstable or had contraindications to MRI. All 6 of 6 (100%) GRE cases (mean age 2.1 years, 7 female, 5 male) demonstrated CMB. CMB were multiple (>3 lesions), situated in cortical or lobar regions, with a striking predominance (5/6 cases) for the right carotid distribution. Other than CMB, no cases demonstrated intracranial hemorrhage. CMB may be noted on GRE MRI after ECMO and may reflect vascular damage from gaseous emboli.
Antibodies as Highly Substrate-Selective Catalysts: Choosing the Right Hapten Can Do The Trick (2019)

Key words catalytic antibodies - haptens - ester hydrolysis - carbonate hydrolysis - transition-state analogues
Oracle Insights: Tales of the Oak Table (2004)

Announcing a new book from Apress and the OakTable Network: Oracle Insights: Tales of the Oak Table presents 11 world-renowned industry specialists proffering their own highly experienced views, input
Biological Markers of Pseudomonas aeruginosa Epidemic High-Risk Clones (2013)

A limited number of Pseudomonas aeruginosa genotypes (mainly ST-111, ST-175, and ST-235), known as high-risk clones, are responsible for epidemics of nosocomial infections by multidrug-resistant (MDR) or extensively drug-resistant (XDR) strains worldwide. We explored the potential biological parameters that may explain the success of these clones. A total of 20 isolates from each of 4 resistance groups (XDR, MDR, ModR [resistant to 1 or 2 classes], and MultiS [susceptible to all antipseudomonals]), recovered from a multicenter study of P. aeruginosa bloodstream infections performed in 10 Spanish hospitals, were analyzed. A further set of 20 XDR isolates belonging to epidemic high-risk clones (ST-175 [n = 6], ST-111 [n = 7], and ST-235 [n = 7]) recovered from different geographical locations was also studied. When unknown, genotypes were documented through multilocus sequence typing. The biological parameters evaluated included twitching, swimming, and swarming motility, biofilm formation, production of pyoverdine and pyocyanin, spontaneous mutant frequencies, and the in vitro competition index (CI) obtained with a flow cytometry assay. All 20 (100%) XDR, 8 (40%) MDR, and 1 (5%) ModR bloodstream isolate from the multicenter study belonged to high-risk clones. No significant differences were observed between clonally diverse ModR and MultiS isolates for any of the parameters. In contrast, MDR/XDR high-risk clones showed significantly increased biofilm formation and mutant frequencies but significantly reduced motility (twitching, swimming, and swarming), production of pyoverdine and pyocyanin, and fitness. The defined biological markers of high-risk clones, which resemble those resulting from adaptation to chronic infections, could be useful for the design of specific treatment and infection control strategies.
Resource scheduling in dependable integrated modular avionics (2002)

In the recent development of avionics systems, integrated modular avionics (IMA) is advocated for next generation architecture that needs integration of mixed criticality real-time applications. These integrated applications meet their own timing constraints while sharing avionics computer resources. To guarantee timing constraints and dependability of each application, an IMA-based system is equipped with the schemes for spatial and temporal partitioning. We refer the model as SP-RTS (strongly partitioned real-time system), which deals with processor partitions and communication channels as its basic scheduling entities. This paper presents a partition and channel-scheduling algorithm for the SP-RTS. The basic idea of the algorithm is to use a two-level hierarchical schedule that activates partitions (or channels) following a distance-constraints guaranteed cyclic schedule and then dispatches tasks (or messages) according to a fixed priority schedule. To enhance schedulability, we devised heuristic algorithms for deadline decomposition and channel combining. The simulation results show the schedulability analysis of the two-level scheduling algorithm and the beneficial characteristics of the proposed deadline decomposition and channel combining algorithms.
Bacterial proteins with cleaved or uncleaved signal peptides of the general secretory pathway (2011)

Correct protein compartmentalization is a key step for molecular function and cell viability, and this is especially true for membrane and externalized proteins of bacteria. Recent proteomic reports of Bacillus subtilis have shown that many proteins with Sec-like signal peptides and absence of a transmembrane helix domain are still observed in membrane-enriched fractions, but further evidence about signal peptide cleavage or soluble protein contamination is still needed. Here we report a proteomic screening of identified peptides in culture filtrate, membrane fraction and whole cell lysate of Mycobacterium tuberculosis. We were able to detect peptide sequencing evidence that shows that the predicted signal peptide was kept uncleaved for several types of proteins such as mammalian cell entry (Mce) proteins and PE or PE-PGRS proteins. Label-free quantitation of all proteins identified in each fraction showed that the majority of these proteins with uncleaved signal peptides are, indeed, enriched in the Triton X-114 lipid phase. Some of these proteins are likely to be located in the inner membrane while others may be outer membrane proteins.
Novel Antibacterial Azelaic Acid BioMOFs (2019)

The development of metal–organic frameworks (MOFs) for bioapplications has gained great relevance over the last few years, mainly due to their potential as drug carriers and/or imaging agents. Although the bioactive azelaic acid has also been widely used as an antibacterial and anti-inflammatory drug, it presents low solubility, so of utmost importance is the development of more soluble formulations with sustained activity. In this contribution, we prove that new azelaic acid-based metal biomolecule frameworks (BioMOFs) are a viable pathway to achieve this goal. Therefore, five novel MOFs were prepared by a simple, low-cost, and environmentally friendly mechanochemical approach, combining azelaic acid with endogenous cations (i.e., K+, Na+, and Mg2+): [K2(H2AZE)(AZE)] (1), [Na4(HAZE)4] (2), [Na2(AZE)(H2O)] (3), and two different polymorphic forms of [Mg(AZE)(H2O)3] (4) and (5) (where H2AZE - neutral azelaic acid; HAZE - mono-deprotonated azelaic acid; AZE - di-deprotonated azelaic acid). After full structural characterization using single-crystal X-ray diffraction data and other complementary standard solid-state techniques, their thermal and moisture stabilities as well as aqueous solubility were assessed. Finally, their antibacterial activity was evaluated against two Gram-positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis), commonly present on the skin. All MOF materials exhibit good stability and higher solubility than azelaic acid. In addition, BioMOF 1 has shown good antibacterial activity both at pH 5 and 6.5. Thus, 1 has shown to be a promising candidate to further develop new topical formulations of H2AZE.
4-AMINO-2-PYRIDO-BICYCLIC PYRIMIDINES AND USE THEREOF AS MEDICAMENTS - 4 AMINO-2-PIRIDO-BICICLO PIRIMIDINE E LORO USOCOME MEDICAMENTI (2016)

The present invention concerns 4-amino-2-pyrido-bicyclic pyrimidines as type II topoisomerase inhibitors and use thereof as medicaments especially in the treatment of cancer. The invention also provides a method for the manufacture of 4-amino-2-pyrido bicyclic pyrimidines.
A new object-order ray-casting algorithm (2002)

Many direct volume rendering algorithms have been proposed during the last decade to render 256/sup 3/ voxels interactively. However a lot of limitations are inherent to all of them, like low-quality images, a small viewport size or a fixed classification. In contrast, interactive high quality algorithms are still a challenge nowadays. We introduce here an efficient and accurate technique called object-order ray-casting that can achieve up to 10 fps on current workstations. Like usual ray-casting, colors and opacities are evenly sampled along the ray, but now within a new object-order algorithm. Thus, it allows to combine the main advantages of both worlds in term of speed and quality. We also describe an efficient hidden volume removal technique to compensate for the loss of early ray termination.
A Controlled Study of the Efficacy of Pentylenetetrazol (Metrazol) with Hard-Core Hospitalized Psychogeriatric Patients (1972)

An 18-week double-blind crossover study of 61 "hard core" geriatric patients with organic brain syndrome compared the efficacy of pentylenetetrazol (Metrazol) with placebo, using a dosage level of 600 mg. per day. Five rating instruments were administered at the beginning, the crossover point, and the end of the study. The results demonstrated no superiority of Metrazol over placebo. Women improved more than men under both conditions. The sequence of administration of medications was not significant. Side effects were noted in only 15 percent of patients on Metrazol and eight percent on placebo.