gebhart/patrepeval huggingface dataset:
Lead Sorption onto Ferrihydrite. 1. A Macroscopic and Spectroscopic Assessment (2003)

In this research, traditional macroscopic studies were complemented with XAS analyses to elucidate the mechanisms controlling Pb(II) sorption onto ferrihydrite as a function of pH, ionic strength, and adsorbate concentrations. Analyses of XANES and XAFS studies demonstrate that Pb(II) ions predominantly sorb onto ferrihydrite via inner-sphere complexation, not retaining their primary hydration shell upon sorption. At higher pH values (pH > or = 5.0), edge-sharing bidentate complexes are mainly formed on the oxide surface with two Fe atoms located at approximately 3.34 A. In contrast, XAS studies on Pb(II) sorption onto ferrihydrite, at pH 4.5, reveal two distinct Pb-Fe bond average radial distances of 3.34 and 3.89 A, suggestive of a mixture of monodentate and bidentate sorption complexes present at the oxide surface. Interestingly, at constant pH, the configuration of the sorption complex is independent of the adsorbate concentration. Hence, Pb(II) sorption to a highly disordered adsorbent such as ferrihydrite can be described by one average type of mechanism. Overall, this information will aid scientists and engineers in improving the current models that predict and manage the fate of toxic metals, such as Pb(II), in the aquatic and soil environments.
Low Dose Naltrexone for Treatment of Multiple Sclerosis (2015)

Turel, Anthony P. MD; Oh, Keun Hee BS; Zagon, Ian S. PhD; McLaughlin, Patricia J. MS, DEd Author Information
Osp/Claudin-11 Forms a Complex with a Novel Member of the Tetraspanin Super Family and β1 Integrin and Regulates Proliferation and Migration of Oligodendrocytes (2001)

Oligodendrocyte-specific protein (OSP)/claudin-11 is a major component of central nervous system myelin and forms tight junctions (TJs) within myelin sheaths. TJs are essential for forming a paracellular barrier and have been implicated in the regulation of growth and differentiation via signal transduction pathways. We have identified an OSP/claudin-11-associated protein (OAP)1, using a yeast two-hybrid screen. OAP-1 is a novel member of the tetraspanin superfamily, and it is widely expressed in several cell types, including oligodendrocytes. OAP-1, OSP/claudin-11, and beta1 integrin form a complex as indicated by coimmunoprecipitation and confocal immunocytochemistry. Overexpression of OSP/claudin-11 or OAP-1 induced proliferation in an oligodendrocyte cell line. Anti-OAP-1, anti-OSP/claudin-11, and anti-beta1 integrin antibodies inhibited migration of primary oligodendrocytes, and migration was impaired in OSP/claudin-11-deficient primary oligodendrocytes. These data suggest a role for OSP/claudin-11, OAP-1, and beta1 integrin complex in regulating proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair.
Collaborative competitive intelligence: A knowledge base system approach (2013)

This study develops a collaborative decision support system to enhance the enterprise competitive intelligence (CI) decision process. A CI knowledge model is constructed by identifying concepts of and relations among instance types, decision models, rules of thumb, and weighting of organization functions. The system consists of: 1) a Domain Ontology of concepts and instances to express the knowledge categorization structure; 2) a Task Ontology to express an objective-oriented knowledge framework to express the combination of questions; and 3) Semantic Rules to develop the logical steps for problem solving. The case experiment results of high Decision Correctness Rate and Departmental Weighting Correctness Rate show that this study has extended CI from information provision to collaborative participatory decision making support for action.
Inkjet printing for microlenses, microcapsules and MEMS-like chip embedding (2013)

Inkjet printing (IJP) is a flexible technique for the fabrication of spherical profiles benefiting from the localized surface tension effects. Combining IJP with top-down well established lithographic approaches enables fabricating spherical shapes with predefinable aspect ratios [1]. In this work, drop-on-demand (DOD) IJP of epoxy inks (InkEpo [2], micro resist technology GmbH) onto specific confinement platforms is presented for three applications: (1) microlens, (2) microcapsules with inner cavities, and (3) microcapsules embedding microchips.
Optical Wavelet Signals Processing and Multiplexing (2005)

We present compact integrable architectures to perform the discrete wavelet transform (DWT) and the wavelet packet (WP) decomposition of an optical digital signal, and we show that the combined use of planar lightwave circuits (PLC) technology and multiresolution analysis (MRA) can add flexibility to current multiple access optical networks. We furnish the design guidelines to synthesize wavelet filters as two-port lattice-form planar devices, and we give some examples of optical signal denoising and compression/decompression techniques in the wavelet domain. Finally, we present a fully optical wavelet packet division multiplexing (WPDM) scheme where data signals are waveform-coded onto wavelet atom functions for transmission, and numerically evaluate its performances.
Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide Versus Dolutegravir/Abacavir/Lamivudine in Antiretroviral-Naive Adults (SYMTRI): A Multicenter Randomized Open-Label Study (PReEC/RIS-57) (2021)

Abstract Background Darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) is the reference for combination therapy based on protease inhibitors due to its efficacy, tolerability, and convenience. Head-to-head randomized comparisons between D/C/F/TAF and combination therapy based on integrase inhibitors in antiretroviral-naive patients are lacking. Methods Adult (&amp;gt;18 years old) human immunodeficiency virus-infected antiretroviral-naive patients (HLA-B∗5701 negative and hepatitis B virus negative), with viral load (VL) ≥500 c/mL, were centrally randomized to initiate D/C/F/TAF or dolutegravir/abacavir/lamivudine (DTG/3TC/ABC) after stratifying by VL and CD4 count. Clinical and analytical assessments were performed at weeks 0, 4, 12, 24, and 48. The primary endpoint was VL &amp;lt;50 c/mL at week 48 in the intention-to-treat (ITT)-exposed population (US Food and Drug Administration snapshot analysis, 10% noninferiority margin). Results Between September 2018 and 2019, 316 patients were randomized and 306 patients were included in the ITT-exposed analysis (151 D/C/F/TAF and 155 DTG/3TC/ABC). Almost all (94%) participants were male and their median age was 35 years. Forty percent had a baseline VL &amp;gt;100 000 copies/mL, and 13% had &amp;lt;200 CD4 cells/μL. Median weight was 73 kg and median body mass index was 24 kg/m2. At 48 weeks, 79% (D/C/F/TAF) versus 82% (DTG/3TC/ABC) had VL &amp;lt;50 c/mL (difference, −2.4%; 95% confidence interval [CI], −11.3 to 6.6). Eight percent versus four percent experienced virologic failure but no resistance-associated mutations emerged. Four percent versus six percent had drug discontinuation due to adverse events. In the per-protocol analysis, 94% versus 96% of patients had VL &amp;lt;50 c/mL (difference, −2%; 95% CI, −8.1 to 3.5). There were no differences in CD4 cell count or weight changes. Conclusions We could not demonstrate the noninferiority of D/C/F/TAF relative to DTG/ABC/3TC as initial antiretroviral therapy, although both regimens were similarly well tolerated.
Robust Single-cell Matching and Multi-modal Analysis Using Shared and Distinct Features Reveals Orchestrated Immune Responses (2021)

The ability to align individual cellular information from multiple experimental sources, techniques and systems is fundamental for a true systems-level understanding of biological processes. While single-cell transcriptomic studies have transformed our appreciation for the complexities and contributions of diverse cell types to disease, they can be limited in their ability to assess protein-level phenotypic information and beyond. Therefore, matching and integrating single-cell datasets which utilize robust protein measurements across multiple modalities is critical for a deeper understanding of cell states, and signaling pathways particularly within their native tissue context. Current available tools are mainly designed for single-cell transcriptomics matching and integration, and generally rely upon a large number of shared features across datasets for mutual Nearest Neighbor (mNN) matching. This approach is unsuitable when applied to single-cell proteomic datasets, due to the limited number of parameters simultaneously accessed, and lack of shared markers across these experiments. Here, we introduce a novel cell matching algorithm, Matching with pARtIal Overlap (MARIO), that takes into account both shared and distinct features, while consisting of vital filtering steps to avoid sub-optimal matching. MARIO accurately matches and integrates data from different single-cell proteomic and multi-modal methods, including spatial techniques, and has cross-species capabilities. MARIO robustly matched tissue macrophages identified from COVID-19 lung autopsies via CODEX imaging to macrophages recovered from COVID-19 bronchoalveolar lavage fluid via CITE-seq. This cross-platform integrative analysis enabled the identification of unique orchestrated immune responses within the lung of complement-expressing macrophages and their impact on the local tissue microenvironment. MARIO thus provides an analytical framework for unified analysis of single-cell data for a comprehensive understanding of the underlying biological system.
Social-Class Differences on the Mc Carthy Scales for Black and White Children (1975)

The relationship of social class to the cognitive and motor Indexes yielded by the McCarthy scales was explored for representative groups of black ( n = 154) and white ( n = 862) children aged 2½ to 8½ yr. For both racial groups, children categorized as middle class scored significantly higher than working-class youngsters on each of the six indexes. The pattern of mean Indexes for different occupational groups resembled the pattern of mean IQs found in previous studies.
Hybrid Holographic Multiplexing for Data Storage and Application to Optical Encryption (2002)

We have implemented a rotationally shifted random-phase encoded multiplexing suitable for the holographic data storage in a photorefractive LiNbO3:Fe crystal. A rotating and shifting circular holographic diffuser is placed as a random-phase modulator in the reference beam of the holographic storage system to provide a simple yet effective approach of increasing data storage capabilities. Experimental results show that the proposed multiplexing scheme can also be combined with angular multiplexing to produce rotationally shifted random-phase encoded and angular multiplexing, offering not only further data storage capabilities but data encryption possibilities as well.
Self-contextual network management system (2006)

Self-adaptation to changes in network context or self-contextual functionality refers to the capability of network nodes to dynamically reconfigure themselves in changing heterogeneous networking environments, in which new services and protocols will be rapidly created and deployed on demand. A novel programmable architecture, called the Future Active IP Networks (FAIN) node, is presented to address the described issues.
Surgeon Quality Control and Standardization of D2 Lymphadenectomy for Gastric Cancer (2020)

Our surgeon quality control study for gastrectomy represents a milestone in surgical standardization for surgical clinical trials. Our methods could also serve as a system for educating surgeons and assessing surgical proficiency.
Synthesis and antiviral activity of 1,2,3-triazole glycosides based substituted pyridine via click cycloaddition (2017)

Novel conjugates of substituted pyridine and carbohydrate moieties linked by 1,2,3-triazoles were synthesized. The propargyl group was introduced by O-propargylation of pyridone derivatives. Attachment of carbohydrate molecules to the substituted pyridine core was performed by Cu-catalyzed cycloaddition of propargyl sugars with azidoethoxypyridine derivative or azido-sugars with substituted (propargyl)oxypyridines which afforded the corresponding 1,2,3-triazoles in high yields. Antiviral activity of synthesized compounds was studied against H5N1 influenza virus and triazolyl glycoside 7 demonstrated high activity in addition to its low toxicity. The effect of attachment of glycosyl triazole moieties to pyridinyl system was studied, in SAR correlation, which has been found to enhance antiviral activity.
CapSense: A Real-Time Capacitive Sensor Simulation Framework for Physical Human-Robot Interaction (2022)

This letter presents CapSense, a real-time open-source capacitive sensor simulation framework for robotic applications. CapSense provides raw data of capacitive proximity sensors based on a fast and efficient 3D finite-element method (FEM) implementation. The proposed framework is interfaced to off-the-shelf robot and physics simulation environments to couple dynamic interaction of the environment with an electrostatic solver for capacitance computation in real-time. The FEM method proposed in this letter relies on a static tetrahedral mesh of the sensor surrounding without a-posteriori re-meshing and achieves high update rates by an adaptive update step. CapSense is flexible due to various configuration parameters (i.e. number, size, shape and location of electrodes) and serves as a platform for investigation of capacitive sensors in robotic applications. By using the proposed framework, researchers can simulate capacitive sensors in different scenarios and investigate these sensors and their configuration prior to installation and fabrication of real hardware. The proposed framework opens new research opportunities via sim-to-real transfer of capacitive sensing. The simulation approach is validated by comparing real-world results of different scenarios with simulation results. In order to showcase the benefits of CapSense in physical Human-Robot Interaction (pHRI), the framework is evaluated in a robotic healthcare scenario.
Superconductivity in single crystals of ZrP1.27Se0.73 (2020)

Results are reported for single crystals of the PbFCl-type layered compound ${\mathrm{ZrP}}_{1.27}{\mathrm{Se}}_{0.73}$ that were produced using the iodine vapor transport method. Electrical transport, magnetization, and heat capacity measurements reveal disordered metallic behavior and the occurrence of bulk superconductivity, with a transition temperature $({T}_{c})$ of 7.1 K and an anisotropic orbitally limited upper critical field. $^{31}\mathrm{P}$ nuclear magnetic resonance measurements provide additional microscopic information, where the line shape, Knight shift, and spin-lattice relaxation data are consistent with the superconductivity originating from the corrugated Zr-P(2c)/Se plane. This suggests that the superconductivity first forms in the corrugated plane and the bulk superconductivity eventually occurs via coupling between the square planar layers. These data also show that either there are multiple superconducting gaps or there is a single gap that does not fully open across the entire Fermi surface. These results clarify the superconducting state in this material and will enable further measurements that require single-crystal specimens.
Identification of an IMPDH1 mutation in autosomal dominant retinitis pigmentosa (RP10) revealed following comparative microarray analysis of transcripts derived from retinas of wild-type and Rho-/- mice (2002)

Comparative analysis of the transcriptional profiles of approximately 6000 genes in the retinas of wild-type mice with those carrying a targeted disruption of the rhodopsin gene was undertaken by microarray analysis. This revealed a series of transcripts, of which some were derived from genes known to map at retinopathy loci, levels of which were reduced or elevated in the retinas of Rho–/– mice lacking functional photoreceptors. The human homologue of one of these genes, encoding inosine monophosphate dehydrogenase type 1 (IMPDH1), maps to the region of 7q to which an adRP gene (RP10) had previously been localized. Mutational screening of DNA from the Spanish adRP family, originally used to localize the RP10 gene, revealed an Arg224Pro substitution co-segregating with the disease phenotype. The amino acid at position 224 of the IMPDH1 protein is conserved among species and the substitution is not present in healthy, unrelated individuals of European origin. These data provide strong evidence that mutations within the IMPDH1 gene cause adRP, and validate approaches to mutation detection involving comparative analysis of global transcription profiles in normal and degenerating retinal tissues. Other genes showing significant alterations in expression include some with anti-apoptotic functions and many encoding components of the extracellular matrix or cytoskeleton, a possible reflection of a response by Muller cells to preserve the remaining outer nuclear layer of the retina. We suggest that those genes identified are prime candidates for etiological involvement in degenerative retinal disease.
The CriLiM Methodology: Crime Linkage with a Fuzzy MCDM Approach (2013)

Grouping events having similarities has always been interesting for analysts. Actually, when a label is put on top of a set of events to denote they share common properties, the automation and the capability to conduct reasoning with this set drastically increase. This is particularly true when considering criminal events for crime analysts, conjunction, interpretation and explanation can be key success factors to apprehend criminals. In this paper, we present the CriLiM methodology for investigating both serious and high-volume crime. Our artifact consists in implementing a tailored computerized crime linkage system, based on a fuzzy MCDM approach in order to combine spatio-temporal, behavioral, and forensic information. As a proof of concept, series in burglaries are examined from real data and compared to expert results.
Supplementary Figure 1 legend from Branched Chain RNA <i>In Situ</i> Hybridization for Androgen Receptor Splice Variant AR-V7 as a Prognostic Biomarker for Metastatic Castration-Sensitive Prostate Cancer (2023)

&lt;p&gt;Supplementary Figure Legend&lt;/p&gt;
Supplementary Figure from Functional Mapping of AKT Signaling and Biomarkers of Response from the FAIRLANE Trial of Neoadjuvant Ipatasertib plus Paclitaxel for Triple-Negative Breast Cancer (2023)

Supplementary Figure from Functional Mapping of AKT Signaling and Biomarkers of Response from the FAIRLANE Trial of Neoadjuvant Ipatasertib plus Paclitaxel for Triple-Negative Breast Cancer
Extracellular vesicles released from hiPSC-derived MSCs attenuate chronic prostatitis/chronic pelvic pain syndrome in rats by immunoregulation (2021)

iMSCs-EVs administration has the potential to ameliorate chronic pelvic pain, improve voiding dysfunction, suppress inflammatory reactions, and facilitate prostatic tissue repair. The functions are mediated by downregulating the overexpression of COX-2 and restoring the imbalance of Th1/Th2 and Treg/Th17 cells.
Crystal structure ofRb4C60under pressure: X-ray diffraction experiments (2006)

We show that ${\mathrm{Rb}}_{4}{\mathrm{C}}_{60}$ transforms from its orientationally disordered tetragonal structure at ambient pressure to an orthorhombic phase in the neighborhood of $0.4\phantom{\rule{0.3em}{0ex}}\mathrm{GPa}$. Lattice parameters, interfullerene distances, and closest Rb-C distances evolve continuously up to $2.2\phantom{\rule{0.3em}{0ex}}\mathrm{GPa}$. Rietveld refinements establish that the high pressure phase is isostructural to ${\mathrm{Cs}}_{4}{\mathrm{C}}_{60}$. The previously observed conducting phase at $0.8\phantom{\rule{0.3em}{0ex}}\mathrm{GPa}$ is therefore structurally distinct from the ambient pressure insulator.
Distributed optimal resource allocation for fading relay broadcast channels (2005)

Resource allocation for a fading orthogonal relay broadcast channel model is investigated, where the source broadcasts to two users using a time-division (TD) scheme in one channel, and the two users transmit relay signals to each other in another orthogonal channel. The channel bandwidth resource is assumed to be allocated equally for broadcast and relay transmissions. Separate power constraints are assumed at the source and the two users. The fading state information is assumed to be known at both the transmitter and receiver of each link, and hence the source and the two users can allocate their power adaptively according to the instantaneous channel state information in a distributed manner. For a fixed allocation of time (for TD broadcast) and power, an achievable rate region based on the relays using the decode-forward scheme for this model is derived. The resource (time and power) allocation is then optimized to maximize each boundary point of this rate region.
Integrating 3D-GIS and Virtual Reality Design and implementation of the Karma VI system (1998)

Virtual reality is becoming a popular tool to visualize 3D GIS data. Direct interaction with the GIS data, however, is often limited. In this paper, we present a multi-view approach to support 3D GIS interaction within VR-environments. This approach is implemented in the Karma VI system, using existing GIS and VR technology. We describe the multi-view approach, the system components and the internal data models, and how CAD models can be imported and be made consitent with the GIS data.
Design of Switched-Inductor Charging Regulator for Resistive On-Chip Thermoelectric Generators (2022)

On-chip thermoelectric generators (TEGs), unlike bulky off-chip TEGs, are easy to integrate and tiny. A CMOS switched-inductor charging regulator (SLCR) both harvests TEG power & draws battery power to supply Internet-of-Things (IoT) wireless microsensors. However, on-chip TEGs output millivolts, carry <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\text{M}\boldsymbol{\Omega }$ </tex-math></inline-formula> source resistance R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">S</sub> , and produce nW power, which demand SLCR to boost low voltage, manage leakage, & maintain high efficiency. Design of such CMOS SLCR power stage often needs prolonged exhaustive tweaking & trial-and-error process. To tackle these challenges, this brief proposes a fundamental theory on the design of nW CMOS SLCR for low-voltage high-R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">S</sub> applications. With closed-form equations, this theory predicts the optimal power switch, optimal inductor, and optimal current profile, such that SLCR can harvest from the lowest voltage with highest efficiency. This brief provides experimental results with a 180-nm CMOS SLCR power stage prototype. With the theory, an optimal CMOS SLCR power stage can be designed with closed-form equations, without extensive trial-and-error efforts.
Mathematical model of glucose-insulin metabolism from carbohydrates in type 1 diabetes during postprandial and postabsorptive states (2013)

In this paper, we propose an extension to our previously developed mathematical model of glucose-insulin metabolism in type 1 diabetes (T1D). It comprises a carbohydrate metabolism subsystem with a solid foundation of the relative impact of carbohydrates on blood glucose levels; an exogenous insulin subsystem that considers the effect of subcutaneous and intravenous rapid-acting insulin; and a glucose-insulin metabolism subsystem in T1D for postprandial and postabsorptive states. Simulations of blood glucose excursion in our model during both states demonstrate the reliability and accuracy of our model.