gebhart/patrepeval huggingface dataset:
COMPARISON OF FSH AND LH PATTERNS IN PLASMA, URINE AND URINARY EXTRACTS DURING THE MENSTRUAL CYCLE (1970)

ABSTRACT Daily urine and plasma specimens were collected during a menstrual cycle in 5 normally ovulating subjects. FSH and LH were measured by radioimmunoassay in plasma, unprocessed urine, dialyzed urine and in urinary extracts. Bioassays of FSH and LH in urinary extracts were also performed. Patterns of FSH and LH during the cycle from measurements in plasma, dialyzed urine and urinary extract by radioimmunoassay agreed well with bioassays of the urinary extracts. The patterns obtained from assays of unprocessed urine did not agree with those of the other measurements. Two or 3 FSH peaks were observed in each cycle and levels of the midcycle peak in plasma were usually greater than earlier peaks. In only one cycle was there more than one significant peak in LH. Quantities of FSH found in plasma, urine and urinary extracts were comparable among subjects within measurements on each body fluid. The magnitude of LH peaks varied considerably among study subjects. Plasma values for both hormones during the c...
Anaplastic oligodendroglial tumors harboring 1p/19q deletion can be successfully treated without radiotherapy. (2011)

Although anaplastic oligodendroglial tumors are known to be chemosensitive, patients under this diagnosis have been traditionally treated with radiotherapy. To avoid possible neurotoxicity, we prospectively treated patients with anaplastic oligodendroglial tumors harboring 1p/19q deletion, with exclusive procarbazine, ACNU, and vincristine chemotherapy without radiotherapy. Twenty-five patients were enrolled in the study (12 with 1p/19q co-deletion, 2 with 1p mono-deletion, 2 with 19q mono-deletion, and 9 without 1p/19q deletion). The median progression-free survival (PFS) was 50 months for all the patients, and those with tumors harboring 1p/19q deletion were progression free for a significantly longer period than those without the deletion (p=0.0391). The median overall survival (OS) time was not reached in both patient groups with and without 1p/19q deletion (p=0.230), and the 5-year OS rate was 62.2% for all patients. The excellent treatment results warrant a large-scale clinical study to confirm the efficacy of upfront chemotherapy omitting radiotherapy as initial therapy for anaplastic oligodendroglial tumors with 1p/19q deletion.
Comparison of vacuum-annealed and electrochemically cycled electrodes in adsorption and electrocatalysis: aromatic compounds at platinum(111) and (polycrystalline) platinum (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComparison of vacuum-annealed and electrochemically cycled electrodes in adsorption and electrocatalysis: aromatic compounds at platinum(111) and (polycrystalline) platinumJohn Y. Gui, Bruce E. Kahn, Laarni Laguren-Davidson, Chiu Hsun Lin, Frank Lu, Ghaleb N. Salaita, Donald A. Stern, and Arthur T. HubbardCite this: Langmuir 1989, 5, 3, 819–828Publication Date (Print):May 1, 1989Publication History Published online1 May 2002Published inissue 1 May 1989https://pubs.acs.org/doi/10.1021/la00087a041https://doi.org/10.1021/la00087a041research-articleACS PublicationsRequest reuse permissionsArticle Views115Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Cloning, expression and purification of cold adapted acetate kinase from Shewanella species AS-11 (2012)

A psychrotrophic bacterium, Shewanella sp. AS-11 was isolated from a buccinid (shell) Neobuccinum living in the Antarctic ice-covered sea. An open reading frame of 1203 bp, coding for acetate kinase gene, called ack, was amplified, cloned into the expression vector, pETY-16b, and the enzyme was overproduced by using T7 system in Escherichia coli BL21 (DE3). After extraction of crude recombinant acetate kinase, the desired enzyme was able to be purified on a Blue Sepharose CL-6B and Super-Q affinity column chromatography. The molecular mass of the enzyme is about 86 kDa, which is associated with two monomers. In respect of pH, the enzyme was stable between 6 to 8 and maximum activity was obtained at 7.5. The purified enzyme was stable at 30°C but ligand bound enzyme was stable at 40°C. The structural comparison to mesophilic and thermophilic acetate kinases demonstrates that the psychrophilic one contains lower number of salt bridges and cation-pi interaction. So, it can be suggested that the enzyme is cold adapted with thermolabile and flexible structure. Keywords: Acetate kinase, thermolabile, cold adapted, flexible, activity African Journal of Biotechnology Vol. 11(29), pp. 7454-7463, 10 April, 2012
IGBT based Three Channel Interleaved PFC Boost Converter for Inverter Front-End Application (2019)

In the proposed paper three stages interleaved boost PFC converter at 60kHz of switching frequency and 3.3kW of power rate with IGBT switches and fast silicon diode is described. The controlled rectifier front-end converter energies a general purpose IGBT single module inverter system used for induction or IPM motor drives. The PFC control circuit applied allows a flexible solution. The interleaved boost PFC stages number can be chosen depending on the output current request. In the paper a comparison of the dynamic performances and converter efficiency will be carried out at different active stages solutions. Furthermore, IGBT constraints for an optimized design of PFC converter are focused.
Reduction of Post-Infarct Ventricular Tachycardia by Transplantation of Transgenic Cardiac Fibroblasts (2023)

Background: Loss of the gap junction protein connexin43 (Cx43) in the lesion area (IA) after myocardial infarction promotes the occurrence of ventricular tachycardia because (myo)fibroblasts (m)FB hardly express Cx43 and/or spike action potentials. To at least partially compensate this loss, we injected Cx43-(over)expressing cardiac FB into the IA and examined the effects on cardiac function and the incidence of ventricular tachycardia (VTi).
Kinetics and Mechanisms of Dehydration of Secondary Alcohols Under Hydrothermal Conditions (2018)

Alcohol dehydration by elimination of water is central to a series of functional group interconversions that have been proposed as a reaction pathway that connects hydrocarbons and carboxylic acids under geochemically relevant hydrothermal conditions such as in sedimentary basins. Hydrothermal dehydration of alcohols is an example of an organic reaction that is quite different from the corresponding chemistry under ambient laboratory conditions. In hydrothermal dehydration, water acts as the solvent and provides the catalyst, and no additional reagents are required. This stands in contrast to the same reaction at ambient conditions, where concentrated strong acids are required. Hydrothermal dehydration is thus of potential interest in the context of green chemistry. We investigated the mechanism of hydrothermal alcohol dehydration for a series of secondary alcohols using studies of kinetics and stereoelectronic effects to establish reaction mechanisms. The E1 elimination mechanism dominates over the corresponding E2 mechanism, with the E2 mechanism being competitive with E1 only for the most favorable stereoelectronically restricted alcohols included in the present study. These results are relevant to understanding the kinetics and product distributions of alcohol dehydration reactions in natural geologic systems and can guide the development of organic chemical reactions that mimic geologic organic reactions under laboratory green chemistry conditions.
Sample capability indices : distributional properties and some applications : theory and methods (2009)

Capability indices (CIs) are popular in the industry, typically used to evaluate a process under statistical control. Being functions of the process mean and the standard deviation, the CIs are actually unknown parameters and yet, in the past, point estimates of these indices, obtained from sampled data, were often used to make the decision, ignoring their sampling variability. In this paper we focus on the distributional and inferential properties of the sample estimators of four popular capability indices CP;CPU;CPL and CPk and show how the exact sampling distributions of the estimated CIs can be derived using the method of conditioning. Important attributes of that distribution, such as the mean and the standard deviation, can then be calculated to arbitrary precision. Hence these important results become more accessible to the practitioners engaged in real-world applications. We also develop hypothesis testing and confidence interval estimation of the CIs, since some of the existing methodology based on a normal approximation is seen to be questionable. Instead, we propose small sample inference based on our distributional results. Finally, we emphasize and illustrate the fact that neither CP nor CPk, alone, can adequately reflect the capability of a process. We propose making joint inference on CP and CPk, using a confidence region that follows from the exact joint distribution of the estimated CIs derived here.
Oxygen radicals mediate the cerebral arteriolar dilation from arachidonate and bradykinin in cats. (1984)

Topical application of sodium arachidonate (50-200 micrograms/ml) or bradykinin (0.1-10 micrograms/ml) on the brain surface of anesthetized cats caused dose-dependent cerebral arteriolar dilation. This dilation was blocked by 67-100% in the presence of superoxide dismutase and catalase. These enzymes did not affect the changes in arteriolar diameter caused by alterations in arterial blood PCO2, or the arteriolar dilation from topical acetylcholine. Enzymes inactivated by heat had no effect on the vasodilation from arachidonate or bradykinin. Superoxide dismutase alone or catalase alone reduced the dilation during application of 200 micrograms/ml of arachidonate for 15 minutes; they also completely prevented the residual dilation seen 1 hour after washout, as well as the reduction in the vasoconstrictive effects of arterial hypocapnia observed at this time. The results show that superoxide anion radical and hydrogen peroxide, or radicals derived from them, such as the hydroxyl radical, are mediators of the cerebral arteriolar dilation from sodium arachidonate or bradykinin. These radicals are not the endothelium-derived relaxant factor released by acetylcholine. The presence of both superoxide anion radical and hydrogen peroxide is required for the production of the vascular damage seen during prolonged application of high concentrations of sodium arachidonate.
Targeted Hypoglossal Neurostimulation in Obstructive Sleep Apnea (2012)

Objective Airway management is the standard approach for the treatment of obstructive sleep apnea (OSA). CPAP remains the gold standard to treat OSAS, but about one‐quarter of the patients are poorly compliant or tolerant to the mask. The aim of the study was to evaluate the safety and efficacy of targetted neurostimulation of the hypoglossal nerve (THN Sleep Therapy) in CPAP non‐compliant subjects using the aura6000™ System from ImThera Medical Inc. Method The study was a single arm, prospective feasibility study on 13 OSA subjects. Apnea‐hypopnea indices (AHI) were measured at 3 and 12 months. A multi‐contact cuff electrode was implanted unilaterally on the proximal hypoglossal nerve and an implantable pulse generator placed subcutaneously in the ipsilateral upper chest wall. Results Significant improvement was found in the apnea hypopnea index: baseline 45.2 ± 17.8, 3 months 21.7 ± 19.9, and 12 months 21.0 ± 16.5 calculated for the 13 patients. Ten patients were classified as responders (76.92%) with a 65.55% improvement in the AHI at 3 months and 68.19% at 12 months and with a 67.09% improvement in the ODI at 3 months and 66.23% at 12 months. Conclusion THN Sleep Therapy™ proved to be a feasible and effective procedure for the treatment of the moderate to severe CPAP noncompliant OSA subjects.
Steinernema phyllophagae n. sp. (Rhabditida: Steinernematidae), a new entomopathogenic nematode from Florida, USA (2011)

Abstract A new species of entomopathogenic nematode, Steinernema phyllophagae n. sp., was isolated from a white grub (Phyllophaga sp.) in a live oak (Quercus virginiana) nursery. The new species is characterised by morphometrics of the infective Sjuvenile (IJ) with body length 1289 (1133-1395) μm, distance from anterior end to the excretory pore 99 (84-120) μm, tail 89 (77-109) μm, ratio a = 31 (27.6-35.5), H% = 57 (51-60) and E% = 110 (70-139). The pattern of the lateral field of IJ of the new species is 2, 5, 6, 8, 6, 2. The male of the first generation can be recognised by the length and shape of the spicule and gubernaculum, position of the excretory pore, D% = 75 (68-80), and GS% = 71 (61-77). The female can be recognised by the vulva having low epiptygma and by the presence of several papilla-like structures near the tail tip. Steinernema phyllophagae n. sp. differs further from other species of Steinernema by characteristics of ITS and D2D3 regions of rDNA.
Telemedicine: A new horizon in public health in India (2008)

Telemedicine is the use of electronic information to communicate technologies to provide and support healthcare when distance separates the participants.(1)

“Tele” is a Greek word meaning “distance “and “mederi” is a Latin word meaning “to heal”. Time magazine called telemedicine “healing by wire”. Although initially considered “futuristic” and “experimental,” telemedicine is today a reality and has come to stay. Telemedicine has a variety of applications in patient care, education, research, administration and public health.(2) Worldwide, people living in rural and remote areas struggle to access timely, good-quality specialty medical care. Residents of these areas often have substandard access to specialty healthcare, primarily because specialist physicians are more likely to be located in areas of concentrated urban population. Telemedicine has the potential to bridge this distance and facilitate healthcare in these remote areas.(3,4)
Chemical Sensors Based on Funstionalized Microcantilever Arrays (2006)

Over the past three decades there have been spectacular developments in micro-electro-mechanical (MEMS) systems. As a result, an innovative family of chemical and biological sensors has emerged. While MEMS represents a diverse family of designs, devices with simple cantilever configurations are especially attractive as transducers for chemical and biological sensors. In this work we discuss chemical sensors based on cantilever arrays functionalized with synthetic responsive phases. In order to analyze multiplexed responses of the cantilever array, we used an artificial neural network (ANN) algorithm. This approach allowed us not only to recognize the individual analytes and binary mixtures, but also to determine the concentration of individual components in a mixture.
Platinum group metal-free electrocatalysts for cathodic oxygen reduction for use in high-temperature proton exchange membrane fuel cells : spectroscopic and mass transport studies (2017)

Today's high and growing energy demands are unsustainable given the cost and depleting nature of fossil fuel sources, and has long been accepted as a major factor in climate change. Due to these factors, alternative clean and renewable energy sources have long been an interest in both academic and industrial research. Electrochemical energy conversion has become one of the leading fields, encompassing both battery and fuel cell technology. Despite being less prevalent in todays society, and still more in the commercially primitive stages, fuel cells demonstrate several benefits over battery technology. Firstly, they can operate consistently, assuming a constant fuel supply, without the need of being shut down and recharged. Additionally, certain systems have potential for residual heat to be collected and used, with these systems being referred to as combined heat and power (CHP) devices.
IL-7 decreases IL-7 receptor (CD127) expression and induces the shedding of CD127 by human CD8+ T cells (2007)

IL-7 receptor alpha (CD127) signaling is essential for T-cell development and regulation of naive and memory T-cell homeostasis. Fewer CD8(+) T cells from HIV-infected patients express CD127 compared with healthy individuals, suggesting that specific host and/or viral factors regulate IL-7 receptor expression. Factors relevant to HIV infection that could potentially decrease CD127 expression on human CD8(+) T cells and the mechanisms by which this occurs were therefore evaluated. IL-7, but not HIV gp120, IL-1-beta, IL-6, IL-10, IL-13, transforming growth factor-beta or tumor necrosis factor-alpha, reduced CD127-surface expression and did so without altering CD127 mRNA expression. Furthermore, IL-7 did not increase the amount of cytoplasmic CD127 in CD8(+) T cells. Interestingly, IL-7 induced the shedding of CD127 from CD8(+) T cells, suggesting a mechanism that may contribute to the increased concentration of CD127 in the plasma of HIV(+) individuals, a novel finding reported here. Naive CD8(+) T cells are more sensitive to IL-7 that mediated the down-regulation of CD127, suggesting that these effects may have particular significance early in T-cell life cycle. Since CD127 down-regulation may be an important contributor to HIV-associated T-cell dysfunction, determining the mechanism thereof may prove to be of considerable significance.
Garantía y control de calidad del ensayo inmunoenzimático de competición en fase sólida para la fiebre aftosa. Parte II. Control de calidad: comparación de dos métodos gráficos para determinar el rendimiento del ensayo (2005)

Diagnostic laboratories are increasingly required to meet stringent quality standards, and validated assays are needed to achieve formal accreditation. Validation of test methods is often considered to be finalised when the assay parameters and characteristics have been established. However, like any process, diagnostic assays are subject to random variation resulting in shifts in the mean test values. Continuous monitoring of assays using control charts will alert the interpreter of changes in performance. For this purpose, several charting methods have been developed and implemented. This paper compares the Shewhart and the exponentially weighted moving average (EWMA) control charts with respect to the day to day monitoring of internal quality control samples for the foot and mouth disease solid phase competition enzyme-linked immunosorbent assay. Both chart types are equally sensitive to shifts, but the EWMA method seems to provide the best balance between false rejection and false acceptance.
Effect of aerosol particle size on bronchodilatation with nebulised terbutaline in asthmatic subjects. (1986)

The bronchodilatation achieved by the beta 2 agonist terbutaline sulphate given as nebulised aerosol from different devices has been measured in seven patients with mild asthma (mean FEV1 76% predicted) over two hours after inhalation. The subjects were studied on four occasions. On three visits they received 2.5 mg terbutaline delivered from three different types of nebuliser, selected on the basis of the size distribution of the aerosols generated; and on a fourth (control) visit no aerosol was given. The size distributions of the aerosols expressed in terms of their mass median diameter (MMD) were: A: MMD 1.8 microns; B: 4.6 microns; C: 10.3 microns. The aerosols were given under controlled conditions of respiratory rate and tidal volume to minimise intertreatment variation. Bronchodilator response was assessed by changes in FEV1, forced vital capacity (FVC), peak expiratory flow (PEF), and maximal flow after expiration of 50% and 75% FVC (Vmax50, Vmax25) from baseline (before aerosol) and control run values. For each pulmonary function index all three aerosols gave significantly better improvement over baseline than was seen in the control (p less than 0.05) and had an equipotent effect on FEV1, FVC, and PEF. Aerosol A (MMD 1.8 microns) produced significantly greater improvements in Vmax50 and Vmax25 than did B or C (p less than 0.05). These results suggest that for beta 2 agonists small aerosols (MMD less than 2 microns) might be advantageous in the treatment of asthma.
Regulation of Cell Fate Decision of Undifferentiated Spermatogonia by GDNF (2000)

The molecular control of self-renewal and differentiation of stem cells has remained enigmatic. Transgenic loss-of-function and overexpression models now show that the dosage of glial cell line-derived neurotrophic factor (GDNF), produced by Sertoli cells, regulates cell fate decisions of undifferentiated spermatogonial cells that include the stem cells for spermatogenesis. Gene-targeted mice with one GDNF-null allele show depletion of stem cell reserves, whereas mice overexpressing GDNF show accumulation of undifferentiated spermatogonia. They are unable to respond properly to differentiation signals and undergo apoptosis upon retinoic acid treatment. Nonmetastatic testicular tumors are regularly formed in older GDNF-overexpressing mice. Thus, GDNF contributes to paracrine regulation of spermatogonial self-renewal and differentiation.
A new development system for reconfigurable digital signal processing (2000)

Requirements for future mobile communications systems are demanding. This paper presents techniques and a development system for the research, design & development of reconfigurable digital signal processing for software radio based systems. Software radio is an essential technology required for the realisation of 3G to meet requirements such as seamless global roaming and protocol independence. This development system ensures that the use of FPGA is practical and realistic when considering the high data rate and multifunctional requirements of 3G systems.
Peptide-dependent stimulation of the ATPase activity of the molecular chaperone BiP is the result of conversion of oligomers to active monomers (1993)

The molecular chaperone BiP purified from bovine liver (bBiP) exhibits a low basal level of ATPase activity that can be stimulated 3-6-fold by synthetic peptides (Flynn, G. C., Chappell, T. G., and Rothman, J. E. (1989) Science 245, 385-390). By contrast, recombinant murine BiP (rBiP) purified to homogeneity following expression in Escherichia coli exhibits a higher basal level of ATPase activity and is much less stimulated by synthetic peptides. Nondenaturing gel electrophoresis showed that rBiP is predominantly monomeric, while bBiP exists in multiple forms probably corresponding to differentially modified monomeric, dimeric, and higher oligomeric species. Some, but not all, synthetic peptides cause conversion of the oligomeric and modified species of bBiP to a monomeric form. We propose that the peptide-dependent ATPase stimulation observed for BiP reflects the conversion of inactive oligomeric and/or modified species into active monomers.