gebhart/patrepeval huggingface dataset:
Crystallographic study and ligand substitution reactions of dirhodium(II) tris- and tetrakis(tritolylbenzoate) (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCrystallographic study and ligand substitution reactions of dirhodium(II) tris- and tetrakis(tritolylbenzoate)Henry J. Callot, Anne Marie Albrecht-Gary, Malak Al Joubbeh, Bernard Metz, and Francois MetzCite this: Inorg. Chem. 1989, 28, 19, 3633–3640Publication Date (Print):September 1, 1989Publication History Published online1 May 2002Published inissue 1 September 1989https://pubs.acs.org/doi/10.1021/ic00318a005https://doi.org/10.1021/ic00318a005research-articleACS PublicationsRequest reuse permissionsArticle Views127Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Synthesis and characterization of InP and InN colloidal quantum dots (2005)

InP quantum dots (QDs) with zinc blende structure and InN QDs with hexagonal structure were synthesized from appropriate organometallic precursors in a noncoordinating solvent using myristic acid as a ligand. The QDs were characterized by TEM, the associated energy dispersive spectroscopy (EDS), electron diffraction, and steady state UV-VIS optical absorption and photoluminescence spectroscopy. To our best knowledge, this paper reports synthesis of InN colloidal quantum dots for the first time.
Intracellular Delivery of Functional Proteins and Native Drugs by Cell-Penetrating Poly(disulfide)s (2015)

The efficient delivery of bioactive compounds into cells is a major challenge in drug discovery. We report herein the development of novel methods for intracellular delivery of functional proteins (including antibodies) and native small-molecule drugs by making use of cell-penetrating poly(disulfide)s (CPDs). CPDs were recently shown to be rapidly taken up by mammalian cells in endocytosis-independent pathways, but their applications for delivery of proteins and native small-molecule drugs have not been demonstrated. With our newly developed, CPD-assisted approaches, rapid and "bioorthogonal" loading of cargos was carried out with pre-synthesized CPDs, in two steps and in a matter of minutes under aqueous conditions. The resulting CPD-cargo conjugates were used immediately for subsequent cell delivery studies. With the versatility and flexibility of these methods, we further showed that they could be used for immediate delivery of a variety of functional cargos with minimum chemical and genetic manipulations. The minimal cell cytotoxicity of these CPDs and their cargo-loaded conjugates further highlights the unique advantage of this new cell-transduction method over other existing strategies and ensures that our entire delivery protocol is compatible with subsequent live-cell experiments and biological studies.
A Modified Calcium Phosphate for Column Chromatography of Polynucleotides and Proteins1 (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Modified Calcium Phosphate for Column Chromatography of Polynucleotides and Proteins1Raymond K. Main, Marjorie J. Wilkins, and Leonard J. ColeCite this: J. Am. Chem. Soc. 1959, 81, 24, 6490–6495Publication Date (Print):December 1, 1959Publication History Published online1 May 2002Published inissue 1 December 1959https://pubs.acs.org/doi/10.1021/ja01533a040https://doi.org/10.1021/ja01533a040research-articleACS PublicationsRequest reuse permissionsArticle Views149Altmetric-Citations74LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
258. Identification of Differentially Expressed Genes in Duchenne Muscular Dystropy Utilising RNAi Technology: Possible Targets for Gene Therapy (2005)

Duchenne Muscular Dystrophy (DMD) is one of a group of genetically heterogeneous muscular dystrophies that are characterized by progressive weakness and wasting of skeletal muscle. Loss of myofibres occurs in response to a deficiency of dystrophin, a protein which is believed to be responsible for myofibre maintenance and integrity. Dystrophin forms a link between the cytoskeleton and the membrane-spanning dystrophin-associated glycoprotein complex (DAPC), indicative of a structural role for dystrophin.
DETERMINACIÓN DE CLORHIDRATO DE LIDOCAÍNA Y EPINEFRINA EN SOLUCIONES ANESTÉSICAS INYECTABLES DE USO DENTAL POR CROMATOGRAFÍA LÍQUIDA DE ALTA EFICIENCIA CON DETECCIÓN U.V. (2003)

En este trabajo se presenta el desarrollo de una metodologia analitica para la cuantificacion de Epinefrina y clorhidrato de Lidocaina por cromatografia liquida en fase reversa, en soluciones anestesicas inyectables de uso dental. A diferencia de la metodologia propuesta en la monografia de la farmacopea norteamericana USP 26, la cual requiere del uso de dos detectores acoplados en serie, unicamente deteccion UV es empleada. El metodo es selectivo, exacto y preciso, como lo indican los resultados de los parametros estudiados durante la validacion.
Controlling CaCO3 particle size with {Ca2+}:{CO32-} ratios in aqueous environments (2021)

The impact of stoichiometry
CO2 Sorption to Subsingle Hydration Layer Montmorillonite Clay Studied by Excess Sorption and Neutron Diffraction Measurements (2012)

Geologic storage of CO2 requires that the caprock sealing the storage rock is highly impermeable to CO2. Swelling clays, which are important components of caprocks, may interact with CO2 leading to volume change and potentially impacting the seal quality. The interactions of supercritical (sc) CO2 with Na saturated montmorillonite clay containing a subsingle layer of water in the interlayer region have been studied by sorption and neutron diffraction techniques. The excess sorption isotherms show maxima at bulk CO2 densities of ≈0.15 g/cm3, followed by an approximately linear decrease of excess sorption to zero and negative values with increasing CO2 bulk density. Neutron diffraction experiments on the same clay sample measured interlayer spacing and composition. The results show that limited amounts of CO2 are sorbed into the interlayer region, leading to depression of the interlayer peak intensity and an increase of the d(001) spacing by ca. 0.5 Å. The density of CO2 in the clay pores is relatively stable over a wide range of CO2 pressures at a given temperature, indicating the formation of a clay-CO2 phase. At the excess sorption maximum, increasing CO2 sorption with decreasing temperature is observed while the high-pressure sorption properties exhibit weak temperature dependence.
Inhibitory Effect of Lupeol on MMPs Expression using Aged Fibroblast through Repeated UVA Irradiation (2018)

In this study, the aged dermal fibroblast model was constructed by repeated irradiation with UV light and the effect of lupeol, a triterpenoid, on anti-aging was confirmed. SA-β-galactosidase (SA-β-gal) stained aged cells increased by about 40% and expression of p-p53, p21, p16 and MMPs (MMP-1, -2, -3) increased in aged fibroblast. As an efficacy result, the treatment of lupeol on aged fibroblast induced by UVA repeated irradiation showed a dose-dependent reduction of SA-β-gal stained aged cells, the expression of p-p53, p21, p16 and inhibition of MMPs. Interestingly, lupeol increased dephosphorylation of p-ERK in repeated UV irradiated conditions. Additionally, lupeol compensated MMPs expression when p-ERK phosphorylation was inhibited by p-ERK inhibitor PD98059. Thus, these results showed that lupeol has a possible effect on MMPs expression using inhibition of the p-ERK pathway. Taken together, we confirmed that lupeol inhibits senescence through inhibiting MMP-1, -2, -3 as well as p-p53, p21 and p16 expression and SA-β-gal activity in repeated UVA-irradiated senescent FB models, therefore suggesting that lupeol may be useful as an anti-aging agent.
ChemInform Abstract: A β‐Lactam Framework as a β‐Alanyl Dication Equivalent: New Synthesis of α‐Amino Acid N‐Carboxy Anhydrides (NCAs) Derived from β‐Substituted Alanines. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
DIAGNOSTIC PERITONEAL LAVAGE (1972)

The Journal of Trauma: Injury, Infection, and Critical Care: November 1972 - Volume 12 - Issue 11 - p 936-938
Ruthenium‐Catalyzed para‐Selective C−H Alkylation of Aniline Derivatives (2017)

The para-selective C-H alkylation of aniline derivatives furnished with a pyrimidine auxiliary is herein reported. This reaction is proposed to take place via an N-H-activated cyclometalate formed in situ. Experimental and DFT mechanistic studies elucidate a dual role of the ruthenium catalyst. Here the ruthenium catalyst can undergo cyclometalation by N-H metalation (as opposed to C-H metalation in meta-selective processes) and form a redox active ruthenium species, to enable site-selective radical addition at the para position.
A conserved imprinting control region at the HYMAI/ZAC domain is implicated in transient neonatal diabetes mellitus (2001)

Transient neonatal diabetes mellitus (TNDM) is associated with intra-uterine growth retardation, dehydration and a lack of insulin. Some TNDM patients exhibit paternal uniparental disomy (UPD) of chromosome 6q24, where at least two imprinted genes, HYMAI and ZAC, have so far been characterized. Here we show that the differentially methylated CpG island that partially overlaps mZac1 and mHymai at the syntenic mouse locus is a likely imprinting control region (ICR) for the approximately 120--200 kb domain. The region is unmethylated in sperm but probably methylated in oocytes, a difference that persists between parental alleles throughout pre- and post-implantation development. We also show that within this ICR, there is a region that exhibits a high degree of homology between mouse and human. Using a reporter expression assay, we demonstrate that this conserved region acts as a strong transcriptional repressor when methylated. Finally, we provide in vivo evidence that in the majority of TNDM patients with a normal karyotype, there is a loss of methylation within the highly homologous region. We propose that this ICR regulates expression of imprinted genes within the domain; epigenetic or genetic mutations of this region probably result in TNDM, possibly by affecting expression of ZAC in the pancreas and/or the pituitary.
On the units of Sabine absorption and the Sabine absorption coefficient (1997)

A century ago, W. C. Sabine demonstrated that sound absorption is fundamental to room acoustics, and introduced the idea for a measure of absorption that has become known as Sabine absorption. Because Sabine absorption and area have the same dimension, e.g., square-meters, many acousticians presume that Sabine absorption has the units of area. For a number of years Robert W. Young has been trying to convince us otherwise, arguing that a dimensionless logarithmic unit distinguishes Sabine absorption from area. [By dimensionless logarithmic unit is meant a scale factor that defines unity on a log scale. The neper (Np) and the decibel are two such quantities.] The metric sabin (Sa) is a unit of Sabine absorption. Defining the metric sabin to be one-half neper square-meter (1 Sa=0.5 Np m2) introduces a logarithmic unit while preserving the numerical scaling of current measurement practice. It follows that the unit of the Sabine absorption coefficient is the half-neper, and a difference between the Sabine absorption coefficient and coefficients from other methods becomes explicit. Among other things, a partial explanation for the experimental observation that Sabine absorption coefficients can exceed unity is provided.
Digital Access and Cross-Connect System II architecture (2003)

A description is given of the AT&T Digital Access and Cross-Connect System II (DACS II), which provides cross-connection, test access, and digital signal processing functions for DS0 signals. Other key functions include facility and equipment maintenance with remote operations support. This is a second-generation DACS that uses a large nonblocking single-stage switch matrix and software control to reassign, process, and distribute up to 15360 individual DS0 channels in up to 640 T1 lines. In addition, any of the 640 DS1 ports can be reserved to provide digital test access for up to 12 DS0 channels at a time.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
In Vitroandin VivoMelanogenesis Inhibition by Biochanin A fromTrifolium pratense (2011)

Our previous study showed that a methanol extract from Trifolium pratense exerted potent inhibitory activity on melanogenesis in mouse B16 melanoma cells. In the present study, the active compound in this Chinese herb extract was isolated and identified as biochanin A by mass spectrum, (1)H-NMR, and (13)C-NMR analysis. The inhibitory effects of biochanin A on melanogenesis were investigated in vitro in cultured melanoma cells and in vivo in zebrafish and mice. Biochanin A dose-dependently inhibited both melanogenesis and cellular tyrosinase activity in B16 cells and in zebrafish embryos. Application of a cream containing 2% biochanin A twice daily to the skin of mice also increased the skin-whitening index value after 1 week of treatment, and the increase continued for another 2 weeks. Biochanin A was confirmed as a good candidate for use as a skin-whitening agent in the treatment of skin hyperpigmentation disorders.
Sparsity in MRI RF excitation pulse design (2008)

Magnetic resonance imaging (MRI) may be viewed as a two-stage experiment that yields a non-invasive spatial mapping of hydrogen nuclei in living subjects. Nuclear spins within a subject are first excited using a radio-frequency (RF) excitation pulse and proportions of excited spins are then detected using a resonant coil; images are then reconstructed from this data. Excitation pulses need to be tailored to a user's specific needs and in most applications need to be as short as possible, due to spin relaxation, tissue heating, signal-to-noise ratio (SNR), and data readout limitations. The design of short-duration excitation pulses is an important topic and the focus of our work. One may show that RF excitation pulse design, under certain conditions, involves choosing to deposit energy in a continuous, 3-D, Fourier-like domain ("excitation k-space") in order to form some desired excitation in the spatial domain. Energy may only be deposited along a 1-D contour, and there are limitations on where and how it may be placed; the most important fact is that excitation pulse duration directly corresponds to the length of the chosen contour and the rate it is traversed. The problem then is to find a sparse "trajectory" (and corresponding energy deposition) within this k-space such that a high-fidelity version of the desired excitation is formed in the spatial domain. We show how sparsity and simultaneous sparsity are applicable to 2-D and 3-D excitation pulse design and present a novel instance where simultaneous sparsity is desirable. We then discuss how to apply sparse approximation concepts to produce RF pulses. These "sparsity-enforced" designs, generated via convex relaxation techniques, significantly outperform conventional pulses: for fixed pulse duration, sparsity-enforced pulses always produce higher-fidelity excitations.
Spectroscopic evidence for preexisting T‐ and R‐state insulin hexamer conformations (1996)

The insulin hexamer is an allosteric protein exhibiting both positive and negative cooperative homotropic interactions and positive cooperative heterotropic interactions (C. R. Bloom et al., J. Mol. Biol. 245, 324–330, 1995). In this study, detailed spectroscopic analyses of the UV/Vis absorbance spectra of the Co(II)-substituted human insulin hexamer and the 1H NMR spectra of the Zn(II)-substituted hexamer have been carried out under a variety of ligation conditions to test the applicability of the sequential (KNF) and the half-site reactivity (SMB) models for allostery. Through spectral decomposition of the characteristic d → d transitions of the octahedral Co(II)-T-state and tetrahedral Co(II)-R-state species, and analysis of the 1H NMR spectra of T- and R-state species, these studies establish the presence of preexisting T- and R-state protein conformations in the absence of ligands for the phenolic pockets. The demonstration of preexisting R-state species with unoccupied sites is incompatible with the principles upon which the KNF model is based. However, the SMB model requires preexisting T- and R-states. This feature, and the symmetry constraints of the SMB model make it appropriate for describing the allosteric properties of the insulin hexamer. Proteins 26:377–390 © 1996 Wiley-Liss, Inc.
Prevalence and characteristics of coronary microvascular dysfunction among chest pain patients in the emergency department (2018)

Despite their low-risk profile, nearly one half of symptomatic and mostly obese emergency department patients without evidence of myocardial infarction or coronary artery disease had CMD. The results could explain the high rates of return visits associated with chest pain, although their application to the general emergency department population require validation.
Functional Dissection and Hierarchy of Tubulin-folding Cofactor Homologues in Fission Yeast (1999)

We describe the isolation of fission yeast homologues of tubulin-folding cofactors B (Alp11) and E (Alp21), which are essential for cell viability and the maintenance of microtubules. Alp11(B) contains the glycine-rich motif (the CLIP-170 domain) involved in microtubular functions, whereas, unlike mammalian cofactor E, Alp21(E) does not. Both mammalian and yeast cofactor E, however, do contain leucine-rich repeats. Immunoprecipitation analysis shows that Alp11(B) interacts with both alpha-tubulin and Alp21(E), but not with the cofactor D homologue Alp1, whereas Alp21(E) also interacts with Alp1(D). The cellular amount of alpha-tubulin is decreased in both alp1 and alp11 mutants. Overproduction of Alp11(B) results in cell lethality and the disappearance of microtubules, which is rescued by co-overproduction of alpha-tubulin. Both full-length Alp11(B) and the C-terminal third containing the CLIP-170 domain localize in the cytoplasm, and this domain is required for efficient binding to alpha-tubulin. Deletion of alp11 is suppressed by multicopy plasmids containing either alp21(+) or alp1(+), whereas alp21 deletion is rescued by overexpression of alp1(+) but not alp11(+). Finally, the alp1 mutant is not complemented by either alp11(+) or alp21(+). The results suggest that cofactors operate in a linear pathway (Alp11(B)-Alp21(E)-Alp1(D)), each with distinct roles.
Fitting the Needs of an Industry (2012)

There have been growing criticisms in recent years among the computer and video games community on the apparent lack of graduates capable of meeting the industry’s employment needs. Following the sharp rise in the number of computer and video games courses across higher education (HE) institutions in the UK and across the globe, this article examines the composition of existing British games design, development, and art programs in relation to prescribed study areas voiced by industry bodies. From a sample of 242 courses, and a further 11 industry-derived and accredited programs, the results explore content currently residing within a variety of games programs and qualification types and evaluate the extent to which such content adheres to the industry’s demand for the focus on specific skills and study areas. The findings point toward certain shortfalls in some key areas deemed to be important by industry professionals and the consideration of the degree to which course providers should cater to the specific demands of industry.
Convergent Enantioselective Synthesis of Vinigrol, an Architecturally Novel Diterpenoid with Potent Platelet Aggregation Inhibitory and Antihypertensive Properties. 1. Application of Anionic Sigmatropy to Construction of the Octalin Substructure (2003)

The coupling of building blocks 15 and 36e in the presence of MgBr(2).OEt(2) at 0 degrees C proceeds with an exo stereoselectivity (3.2:1) considerably more advantageous for the acquisition of carbinol 37e than in the absence of the additive (exo/endo = 1:5.7). The pivotal transformation that sets all of the relevant stereocenters of the cis-octalin 55 is the oxyanionic-accelerated [3,3]-sigmatropic rearrangement of 37e. A salient feature is the structurally enforced adoption of a boatlike transition state that serves to properly set four vicinal methine hydrogens in an all-cis arrangement. The ensuing conversion of 55 into iodo sulfone 62 has permitted X-ray crystallographic confirmation of all absolute stereochemical assignments since the isopropyl substituent was initially installed enantioselectively via the Evans oxazolidinone protocol. No intramolecular anionic cyclization of 62 to generate the tricyclic framework was seen. This absence of reactivity is attributed to conformational factors that inhibit attainment of the proper S(N)2 reaction trajectory.
Domestic Dishwasher Simulated Energy Efficiency Evaluation Using Thermoelectric Heat Pump for Water Heating and Dish Drying (2018)

A quasi-steady state, heat and mass transfer lumped-capacitance model was developed to predict the energy consumption and drying performance of domestic dishwashers. A numerical finite element solution was applied, assuming that the following components could each be treated as a lumped thermal capacitance: dish load, tub, wash water, and air in tub. The model was used to predict the energy consumption savings of heating water using a thermoelectric heat pump that extracts heat from a thermal storage medium, and the drying performance of circulating tub air through the cold and then hot side of TE modules.