gebhart/patrepeval huggingface dataset:
High Temperature SELMA: Evolution of DNA-Supported Oligomannose Clusters Which Are Tightly Recognized by HIV bnAb 2G12 (2014)

SELMA (SELection with Modified Aptamers) is a directed evolution method which can be used to develop DNA-supported clusters of carbohydrates in which the geometry of clustering is optimized for strong recognition by a lectin of interest. Herein, we report a modification of SELMA which results in glycoclusters which achieve dramatically stronger target recognition (100-fold) with dramatically fewer glycans (2-3-fold). Our first applications of SELMA yielded clusters of 5-10 oligomannose glycans which were recognized by broadly neutralizing HIV antibody 2G12 with moderate affinities (150-500 nM Kd's). In the present manuscript, we report glycoclusters containing just 3-4 glycans, which are recognized by 2G12 with Kd's as low as 1.7 nM. These glycoclusters are recognized by 2G12 as tightly as is the HIV envelope protein gp120, and they are the first constructs to achieve this tight recognition with the minimal number of Man9 units (3-4) necessary to occupy the binding sites on 2G12. They are thus of great interest as immunogens which might elicit broadly neutralizing antibodies against HIV.
Novel FIR-Filter Configuration Tolerant to Fast Phase Fluctuations in Digital Coherent Receivers for Higher-Order QAM Signals (2012)

We propose a novel configuration of FIR filters adapted by the decision-directed LMS algorithm in the digital coherent receiver. Simulations and experiments show its high tolerance to phase noise and frequency offset for 16-QAM signals.
Decreased Cardiac Output, Venous Congestion and the Association with Renal Impairment in Patients with Cardiac Dysfunction (2007)

RBF is the main factor determining GFR in patients with cardiac dysfunction. Venous congestion, characterised by an increased RAP, adjusted for RBF is also related to GFR. Treatment to preserve GFR should not only focus on improvement of renal perfusion, but also on decreasing venous congestion.
Metformin, but not pioglitazone, decreases postchallenge plasma ghrelin levels in type 2 diabetic patients: a possible role in weight stability? (2008)

Metformin, but not pioglitazone, decreased plasma ghrelin levels after the glucose load. This decrease may in part account for weight stability in type 2 diabetic patients treated with metformin.
Silane nanofilm formation by sol-gel processes for promoting adhesion of waterborne and solvent-borne coatings to wood surface (2015)

Abstract The objective of this study was to promote the adhesion of waterborne and solvent-borne coatings [polyurethane (PU) and alkyd] on wood surfaces by silane nanofilm formation by means of sol-gel processes. Tetraethoxysilane and glycidoxypropyltrimethoxysilane served as sol-gel materials. The silane-based materials improved the adhesion strength. The positive effects can be explained by the changes in the wood surface chemistry induced by the sol-gel process. High-resolution X-ray photoelectron spectroscopy (XPS) showed an increase in -C-H and -C-C bonds and a decrease in -C-O bond. Microscopic observation by fluorescence and confocal laser scanning microscopy together with NIS-Elements analysis software showed that the silica component of nanosol covered the whole wood surface homogeneously, whereas alkyd and PU coatings were deposited preferentially in the surface depressions. The combined analysis of energy-dispersive X-ray analysis and XPS demonstrated that the surface was covered with silicon oxides (SiO 2 ) attached to hydrocarbon chains.
Perturbation of cochlear microphonics by an intracellular electrode in the organ of Corti (1988)

Recording the receptor potentials of cochlear inner and outer hair cells in situ has become an essential part of cochlear research. To reach the cells, the recording electrode has to traverse parts of the organ of Corti. Such intrusion may affect the cochlear micromechanics. This possibility was tested by recording scala-media CM in the second cochlear turn in Mongolian gerbils. A small hole was drilled in the cochlear bony capsule above the basilar membrane, and an intracellular electrode was made to traverse Hensen's cells all the way to the OHCs. A second electrode placed in the endolymph recorded CM amplitude and phase as a function of sound frequency. Our results indicate that an intracellular electrode lodged in the organ of Corti can produce substantial changes in CM tuning. This means that the cochlear micromechanics was perturbed. [Work supported by Javits Grant NS 03950.]
A feasible method to find areas with constraints using hierarchical depth-first clustering (2002)

Addresses a reliable, feasible method to find geographical areas with constraints using hierarchical depth-first clustering. The method involves multi-level hierarchical clustering with a depth-first strategy, depending on whether the area of each cluster satisfies the given constraints. The attributes used in the hierarchical clustering are the coordinates of the grid data points. The constraints are an average value range and the minimum size of an area with a small proportion of missing data points. Convex-hull and point-in-polygon algorithms are involved in examining the constraint satisfaction. The method is implemented for an Earth science data set for vegetation studies - the Normalized Difference Vegetation Index (NVDI).
Calcitriol‐induced prostate‐derived factor: Autocrine control of prostate cancer cell growth (2004)

Calcitriol (1alpha,25-dihydroxycholecalciferol) seems to play an important role in the complex control of prostate cell growth. It inhibits proliferation and induces differentiation and apoptosis in prostate cancer cells. However, the molecular mechanisms of the antiproliferative activity of calcitriol are not completely understood. The expression of prostate-derived factor (PDF), a member of the transforming growth factor-beta (TGF-beta) superfamily, has been shown to be associated with proapoptotic and antimitotic activities. We show that calcitriol induces PDF expression in LNCaP human prostate cancer cells in a concentration- and time-dependent manner. In LNCaP cells, the suppression of cell growth by calcitriol is accompanied by stimulation of PDF mRNA and protein synthesis. Human recombinant PDF inhibits LNCaP cell growth. We do not detect any effect of PDF-specific antibody on the basal growth of LNCaP cells, but this antibody partially reverses the suppression of LNCaP cell growth by calcitriol, suggesting that the effect of calcitriol on cell growth is at least partially mediated by PDF. In PC-3 cells, which are less responsive to the growth-inhibitory effect of calcitriol, it has no effect on PDF expression. We do not detect an effect of recombinant PDF on SMAD phosphorylation in LNCaP cells, but ERK1/2 kinases are transiently phosphorylated in response to PDF, which suggests that in LNCaP cells PDF may exert its action through pathway alternative to the classical TGF-beta signaling pathway. The present study describes the regulation of PDF, the proapoptotic protein of the TGF-beta superfamily, by calcitriol in androgen-responsive prostate cancer cells. This is a new link between calcitriol and growth factors of TGF-beta superfamily in the control of prostate cell growth.
Ethanol and the environment: Clarifying the controversy (1993)

Domestic transportation fuels are almost exclusively (about 97%) derived petroleum and account for about 64% of the total petroleum used in the United States. Few substitutes are currently available for petroleum-based transportation fuels, making the United States extremely vulnerable, both strategically and economically, to supply disruptions. In recent years, interest in ethanol as a fuel extender, octane enhancer, and oxygenate has increased dramatically because of concerns associated with conventional transportation fuels. Ethanol is produced commercially from sugar in Brazil and starch crops in United States. However, lignocellulosic biomass such as agricultural residues, forestry wastes, municipal solid waste, and dedicated energy crops can also be converted into ethanol. This resource provides a low-cost, abundant feedstock that would support large-scale ethanol production in this country. Ethanol can be used as a 10% blend, reacted with isobutylene to form ethyl tertiary butyl ether (ETBE), or used directly as a neat fuel. The fuel properties and processing requirements of each of these options must be properly accounted for in order to compare the merits of ethanol use with conventional fuels. The advantages and disadvantages of using ethanol as a blend, as ETBE, or as a neat fuel will be discussed and an overview ofmore » enzymatic hydrolysis technology for producing ethanol from lignocellulosic biomass will be present.« less
Glucosylceramide Synthase Is Involved in Development of Invariant Natural Killer T Cells (2017)

Invariant natural killer T (iNKT) cells represent a unique population of CD1d-restricted T lymphocytes expressing an invariant T cell receptor encoded by Vα14-Jα18 and Vα24-Jα18 gene segments in mice and humans, respectively. Recognition of CD1d-loaded endogenous lipid antigen(s) on CD4/CD8-double positive (DP) thymocytes is essential for the development of iNKT cells. The lipid repertoire of DP thymocytes and the identity of the decisive endogenous lipid ligands have not yet been fully elucidated. Glycosphingolipids (GSL) were implicated to serve as endogenous ligands. However, further <i>in vivo</i> investigations were hampered by early embryonal lethality of mice deficient for the key GSL-synthesizing enzyme glucosylceramide (GlcCer) synthase [GlcCer synthase (GCS), EC 2.4.1.80]. We have now analyzed the GSL composition of DP thymocytes and shown that GlcCer represented the sole neutral GSL and the acidic fraction was composed of gangliosides. Furthermore, we report on a mouse model that by combination of Vav-promoter-driven iCre and floxed GCS alleles (<i>Vav <sup><b>Cre</b></sup> GCS <sup><b>f/f</b></sup></i> ) enabled an efficient depletion of GCS-derived GSL very early in the T cell development, reaching a reduction by 99.6% in DP thymocytes. Although the general T cell population remained unaffected by this depletion, iNKT cells were reduced by approximately 50% in thymus, spleen, and liver and showed a reduced proliferation and an increased apoptosis rate. The Vβ-chains repertoire and development of iNKT cells remained unaltered. The GSL-depletion neither interfered with expression of CD1d, SLAM, and Ly108 molecules nor impeded the antigen presentation on DP thymocytes. These results indicate that GlcCer-derived GSL, in particular GlcCer, contribute to the homeostatic development of iNKT cells.
Broussonetia papyrifera Vent. (2002)

https://thekeep.eiu.edu/herbarium_specimens_byname/20002/thumbnail.jpg
Wrinkle Suppression Method with Quantified Forming Limit for Bending Flange Wrinkles in High Strength Steel Panels (2018)

Recently, for the weight reduction of automotive bodies, steel sheets used in automobiles have been becoming thinner owing to the application of high-strength steels. Press forming of high-strength steels, however, has many problems. Wrinkle formation is one of the most serious problems in press forming, especially in the application of highstrength steels. The cause of wrinkle formation has not yet been completely understood, particularly in the case of bending flange wrinkles, which are common in automotive parts forming. There are, therefore, few well-known methods of satisfactorily preventing bending flange wrinkles. In order to prevent bending flange wrinkles, it is important to understand the effect of press conditions on wrinkle formation. In this study, cylindrical forming experiments simulating bending flange wrinkle formation in press forming of automotive body parts were conducted to clarify the forming limit for wrinkles, that is, the critical circumferential strain, which is the threshold of bending flange wrinkle formation. In addition, a new method of wrinkle suppression by die shoulder shape optimization was developed on the basis of the results of the above experiments. A die shoulder shape was designed such that the edge of the blank remains in contact with the die shoulder. The superiority of the developed design method was verified by forming experiments.
Locked Plates Combined With Minimally Invasive Insertion Technique for the Treatment of Periprosthetic Supracondylar Femur Fractures Above a Total Knee Arthroplasty (2006)

Fixation of periprosthetic supracondylar femur fractures with a locking plate provided satisfactory results in nondiabetic patients. Diabetic patients seem to be at high risk for healing complications and infection.
ANTINEURODEGENERATIVE ACTIVITY OF MICROALGAE DUNALIELLA SALINA IN RATS WITH ALZHEIMER’S DISEASE (2016)

ABSTRACTObjective: The present study is aimed to investigate the promising action of Dunaliella salina extract as a natural protector against Alzheimer’sdisease (AD) and reported to possess a variety of activities, including antioxidant effects due to its ability to create large amount of carotenoids.Methods: D. salina is a type of halophile green microalgae was used in the present study. 50 male rats were used in this study, where aluminumchloride was orally administered to induce AD in a dose of 100 mg/kg, daily for 6 weeks. Al-intoxicated rats treated orally daily with D. salinaethanolic extract for 6 weeks in a dose of 150 mg/kg b.wt., whereas standard anti-Alzheimer drug donepezil tartrate was administered at the doseof 10 mg/kg b.wt./day for 6 consecutive weeks. The anti-Alzheimer properties of D. salina extract were achieved through measuring the calmodulin(CaM) level, paraoxonase 1 (PON1) activity, the antiapoptotic marker (Bcl2), brain-derived neurotrophic factor (BDNF), the generation of the DNAadducts (8-hydroxy-2-deoxyguanosine [8-OHdG]/2-deoxy guanosine [2-dG]), and alteration in the expression of amyloid precursor protein, β-siteAPP-cleaving enzyme 1 (BACE1), and β-site APP-cleaving enzyme 2 (BACE2) in AD rats.Results: The current results demonstrated that supplementation of AD rats with D. salina extract-enhanced CaM level, and increased PON1 activity,upregulated Bcl2 and BDNF, decreased the levels of DNA adducts (8-OHdG/2-dG), and suppressed the alterations of the expression levels of APP,BACE1, and BACE2-m RNAs as compared with those in AD rats.Conclusion: It could be concluded that the biological activity of D. salina extract might be regulated by 9-cis b-carotene protecting the brain cells fromthe oxidative stress in AD rats.Keywords: Dunaliella salina, Calmodulin, Paraoxonase 1, Bcl2, Brain-derived neurotrophic factor, Alzheimer’s disease, DNA adduct, Amyloid precursorprotein.
Angiographic Patterns of In-Stent Restenosis (1999)

The introduced angiographic classification is prognostically important, and it may be used for appropriate and early patient triage for clinical and investigational purposes.
Fast, flexible, cycle-accurate energy estimation (2001)

Article Share on Fast, flexible, cycle-accurate energy estimation Authors: Phillip Stanley-Marbell Department of Electrical and Computer Engineering, Rutgers University, Piscataway, NJ Department of Electrical and Computer Engineering, Rutgers University, Piscataway, NJView Profile , Michael Hsiao Department of Electrical and Computer Engineering, Rutgers University, Piscataway, NJ Department of Electrical and Computer Engineering, Rutgers University, Piscataway, NJView Profile Authors Info & Claims ISLPED '01: Proceedings of the 2001 international symposium on Low power electronics and designAugust 2001 Pages 141–146https://doi.org/10.1145/383082.383120Published:06 August 2001Publication History 27citation375DownloadsMetricsTotal Citations27Total Downloads375Last 12 Months10Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Supplementary Figure 5 from Suppression of Proximal T Cell Receptor Signaling and Lytic Function in CD8<sup>+</sup> Tumor-Infiltrating T Cells (2023)

Supplementary Figure 5 from Suppression of Proximal T Cell Receptor Signaling and Lytic Function in CD8&lt;sup&gt;+&lt;/sup&gt; Tumor-Infiltrating T Cells
Experimental investigation of the asymmetric body vortex wake (1980)

An experimental investigation of the asymmetric body vortex wake of a circular cylinder in high subsonic flow is presented. Laser velocimeter, force and moment, and surface hot wire measurements were obtained for a freestream Mach number of 0.6 and Reynolds number (based on body diameter) of 0.62 x 10 to the 6th. Two component laser velocimeter measurements were made at three body cross-flow planes, x/d = 4, 8, and 12, and angles of attack of 25, 35, and 45 deg. Laser vapor screen photographs were also obtained at these body stations and angles of attack. Surface hot wire measurements were used to determine if any vortex switching occurred at various angles of attack of the body. The laser velocimeter measurements are related to the vapor screen photographs and side force measurements. These results show that more than one asymmetric body vortex wake configuration can exist for the same angle of attack and body roll angle.
Percutaneous Mitral Valve Repair for Chronic Ischemic Mitral Regurgitation (2005)

Percutaneous coronary sinus-based mitral annuloplasty reduces chronic IMR by reducing mitral annular A-P diameter and MVTa. This suggests the potential clinical application of a new nonsurgical therapeutic approach in patients with IMR.
CDG or not CDG (2022)

sponsorship: National Institute of Diabetes and Digestive and Kidney Diseases, Grant/Award Number: R01DK99551; National Institute of Neurological Disorders and Stroke, Grant/Award Number: U54 NS115198; The Rocket Fund (National Institute of Diabetes and Digestive and Kidney Diseases|R01DK99551, National Institute of Neurological Disorders and Stroke|U54 NS115198, Rocket Fund, Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Advancing Translational Sciences; NIH Office of the Director; National Institute of Neurological Disorders and Stroke|U54NS115198, National Institute of Diabetes and Digestive and Kidney Diseases|R01DK099551)
VSTEP-based smart pixels (1993)

The design features and characteristics of a laser-mode vertical-to-surface transmission electro-photonic (VSTEP) device with high-intensity light output and narrow optical beam divergence are discussed. It is shown that a 20- mu m square VSTEP with an optimized vertical cavity structure demonstrates a low optical switching energy of 2.2 pJ, together with a low threshold current. In order to lower the series resistance, and to improve electrical-to-optical conversion efficiency eta /sub T/, a double mesa structure VSTEP was fabricated. The whole mesa is covered with Au to utilize the threshold reduction by photon recycling. As a result, eta /sub T/ is improved to 11% at 1 mW light output. Two approaches to achieving VSTEP-based smart pixels are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A DT 0–2 MASH ΣΔ modulator with VCO-based quantizer for enhanced linearity (2012)

This paper presents a new structure of the discrete time 0–2 MASH sigma-delta modulator implemented with VCO-based quantizer in the second stage. The proposed scheme enhances the linearity of the VCO based quantizer, meanwhile it takes advantage of the intrinsic DEM function and first order noise shaping in the second stage. Besides, the matching requirement is relaxed and the digital canceling filter is largely simplified. Moreover, no additional active adder in or between two stages is needed because of the 0–2 MASH structure, which can save a lot of power. The proposed DT 0–2 MASH sigma-delta (ΣΔ) modulator with 10MHz signal bandwidth for wideband applications is designed and simulated in Matlab. The performance of the modulator can reach 97dB SND Runder a sampling rate of 1.15GHz.
Lupeol, a dietary triterpene, inhibits the proliferation of human prostate cancer cells: modulation of microtubule assembly and inhibition of proteosome (2008)

3270 Recent studies from our laboratory showed that Lupeol induces apoptosis and inhibits the tumorigenicity of androgen-sensitive human prostate cancer (PCa) cells in animal models. Current study was aimed to understand the mechanism which precedes the apoptotic process induced by Lupeol in PCa cells. We observed that Lupeol (5-50 μM) treatment significantly was equally effective in decreasing the viability of androgen-sensitive (LNCaP) as well as androgen-insensitive (DU145 and PC-3) cells. Further, Lupeol treatment inhibited the proliferative and clonogenic potential of all PCa cells when observed for 21 days. Since Lupeol was observed to inhibit the proliferation of PCa cells, we asked if Lupeol interferes in the cell cycle process of PCa cells. We observed that Lupeol induces G2/M cell cycle arrest of PCa cells. The phenomenon of G2/M cell cycle arrest is a microtubule regulated process. The importance of microtubules in cell division makes them an important target for anticancer drugs. Since we observed that Lupeol induces G2/M cell cycle arrest we next investigated its effect on microtubule assembly in PCa cells. Interestingly, Lupeol treatment was observed to decrease the expression level of α and β-tubulin. The critical balance between mitotic arrest and exit is maintained by CDKp34/Cyclin B1 complex. We observed that Lupeol treatment causes a reduction in the expression level of Cyclin B1, modulation in Cyclin/Cdk complex and an increase in p21 protein. Mitotic spindle checkpoint is reported to be regulated by Survivin protein which exhibits an aberrant expression level in PCa patients. Lupeol was found to significantly reduce the expression level of Survivin in PCa cells. Stathmin protein (also known as oncoprotein 18) is known to regulate microtubule dynamics and its expression level is known to be highly increased in various malignancies. Lupeol treatment caused a significant reduction in the expression level of Stathmin in PCa cells. The involvement of proteosome in the regulation of cell cycle and microtubule dynamics is well known. MG132, a well known proteosome inhibitor was observed to significantly decrease the expression level of β-tubulin, and Cyclin D1 in PCa cells. Interestingly, MG132-mediated effects were observed to increase several fold in PCa cells treated with Lupeol suggesting a synergistic effect of Lupeol and MG132. However, Lupeol did not change the expression level of Survivin in the presence of proteosome inhibitor MG132 suggesting that Lupeol-induced modulation in microtubule assembly is at least in part dependent on proteosome. We suggest that Lupeol could be used alone or as an adjuvant to known microtubule and proteosome targeting agents for the treatment of PCa.