gebhart/patrepeval huggingface dataset:
Developmental Stage, Muscle and Genetic Type Modify Muscle Transcriptome in Pigs: Effects on Gene Expression and Regulatory Factors Involved in Growth and Metabolism (2016)

Iberian pig production includes purebred (IB) and Duroc-crossbred (IBxDU) pigs, which show important differences in growth, fattening and tissue composition. This experiment was conducted to investigate the effects of genetic type and muscle (Longissimus dorsi (LD) vs Biceps femoris (BF)) on gene expression and transcriptional regulation at two developmental stages. Nine IB and 10 IBxDU piglets were slaughtered at birth, and seven IB and 10 IBxDU at four months of age (growing period). Carcass traits and LD intramuscular fat (IMF) content were measured. Muscle transcriptome was analyzed on LD samples with RNA-Seq technology. Carcasses were smaller in IB than in IBxDU neonates (p < 0.001), while growing IB pigs showed greater IMF content (p < 0.05). Gene expression was affected (p < 0.01 and Fold change > 1.5) by the developmental stage (5,812 genes), muscle type (135 genes), and genetic type (261 genes at birth and 113 at growth). Newborns transcriptome reflected a highly proliferative developmental stage, while older pigs showed upregulation of catabolic and muscle functioning processes. Regarding the genetic type effect, IBxDU newborns showed enrichment of gene pathways involved in muscle growth, in agreement with the higher prenatal growth observed in these pigs. However, IB growing pigs showed enrichment of pathways involved in protein deposition and cellular growth, supporting the compensatory gain experienced by IB pigs during this period. Moreover, newborn and growing IB pigs showed more active glucose and lipid metabolism than IBxDU pigs. Moreover, LD muscle seems to have more active muscular and cell growth, while BF points towards lipid metabolism and fat deposition. Several regulators controlling transcriptome changes in both genotypes were identified across muscles and ages (SIM1, PVALB, MEFs, TCF7L2 or FOXO1), being strong candidate genes to drive expression and thus, phenotypic differences between IB and IBxDU pigs. Many of the identified regulators were known to be involved in muscle and adipose tissues development, but others not previously associated with pig muscle growth were also identified, as PVALB, KLF1 or IRF2. The present study discloses potential molecular mechanisms underlying phenotypic differences observed between IB and IBxDU pigs and highlights candidate genes implicated in these molecular mechanisms.
The crystal structure and stereochemistry of 2-acetyl-3,5,6-trihydroxy-5,6-dimethyl-2-cyclohexenones (1988)

The stereochemistry of 3a, one of the 2-acetyl-3,5,6-trihydroxy-5,6-dimethylcyclohexenones, obtained by rearrangement of 2,3-diacetyl-4-hydroxy-4-methylcyclopentenone, 2a, under basic conditions, was determined by an X-ray crystal structure analysis. An ORTEP plot shows the configuration of (5RS,6RS)-2-acetyl-3,5,6-trihydroxy-5,6-dimethylcyclohexenone and the presence of a conjugated chelated system involving the H-bonding between O(3)… H(31) and H(31)… O(2).Crystals of 3a are triclinic, a = 10.979(4), b = 7.766(3), c = 6.382(3) Å, α = 86.23(2), β = 72.86(1), γ = 88.23(2)°, Z = 2, space group [Formula: see text]. The structure was solved by direct methods and was refined by full-matrix least-squares procedures to R = 0.036 and R w = 0.039 for 1324 reflections with I &gt; 3σ(I).The structure of 3a consists of centrosymmetric dimers which contain a nearly planar bicyclic system of a cyclohexenone moiety and a chelated system (Scheme 2).The pathway of the reaction allows one to put forward some hypothesis on the stereochemistry of some analogues of the cyclohexenones 3a and 3b.Faisant appel à la diffraction des rayons-X, on a déterminé la stéréochimie du composé 3a, une des acétyl-2 trihydroxy-3,5,6 diméthyl-5,6 cyclohexénones obtenues par une transposition de la diacétyl-2,3 hydroxy-4 méthyl-4 cyclopenténone, 2a, en milieu alcalin. Une courbe ORTEP démontre que la configuration est (5RS,6RS) pour l'acétyl-2 trihydroxy-3,5,6 diméthyl-5,6 cyclohexénone et qu'il existe un système de chélation conjugué impliquant des liaisons hydrogènes entre O(3)… H(31) et H(31)… O(2).
Supplementary Figure 1 from <i>In Vivo</i> Imaging of Drug-Induced Mitochondrial Outer Membrane Permeabilization at Single-Cell Resolution (2023)

&lt;p&gt;PDF file, 394KB, Fig. S1: Colocalization of IMS-RP with full-length Smac/DIABLO and AIF.&lt;/p&gt;
Trabectome Surgery Combined with Baerveldt Glaucoma Implantation Negates Tube Fenestration (2017)

Purpose: To evaluate the efficacy and survival rates of the same session ab interno trabeculectomy with trabectome and Baerveldt glaucoma implant (BT) compared to Baerveldt implant alone (B). Method: A total of 175 eyes undergoing primary glaucoma surgery were enrolled in this retrospective comparative case series, including 60 eyes which underwent BT and 115 eyes which received B alone. Participants were identified using the procedural terminology codes, and their medical records were reviewed. The primary outcome measure was surgical success defined as 5 mmHg > IOP ≤ 21 mmHg and IOP reduction ≥ 20% from baseline, no reoperation for glaucoma, and no loss of light perception vision. Secondary outcome measures were intraocular pressure, the number of glaucoma medications, and best corrected visual acuity (BCVA). Results: The cumulative probability of success at 1 year was 61% in BT, and 50% in B. IOP decreased significantly from 23.6±8.9 mmHg at baseline to 13.7±3.9 mmHg at the final follow up in BT (P= 0.001). The corresponding numbers for B were 23.3±7.5 and 14.2±4.5, respectively (P= 0.001). There was no significant difference in IOP at the final follow-up (P=0.56). The number of medications at baseline was comparable in both groups (2.1±1.1 in BT versus 2.4±1 in B, p=0.07). However, BT needed statistically significant fewer drops in all postoperative time intervals and used 0.9±0.9 (BT) and 1.6±1.2 eyedrops (B) at the final follow-up visit (P= 0.004). No dangerous hypertony or hypertension occurred in BT. Conclusion: Similar rates of success and IOP reduction were observed in BT and B. Eyes who underwent trabectome surgery needed significantly fewer glaucoma medications during 1-year follow-up period while tubes did not require fenestration resulting in fewer postoperative hypotony or hypertension.
The Human Magel2 Gene and Its Mouse Homologue Are Paternally Expressed and Mapped to the Prader-Willi Region (1999)

Prader-Willi syndrome (PWS) is a complex neurogenetic disorder. The phenotype is likely to be a contiguous gene syndrome involving genes which are paternally expressed only, located in the human 15q11-q13 region. Four mouse models of PWS have been reported but these do not definitively allow the delineation of the critical region and the associated genes involved in the aetiology of PWS. Moreover, targeted mutagenesis of mouse homologues of the human candidate PWS genes does not appear to result in any of the features of PWS. Therefore, the isolation of new genes in this region remains crucial for a better understanding of the molecular basis of PWS. In this manuscript, we report the characterization of MAGEL2 and its mouse homologue Magel2. These are located in the human 15q11-q13 and mouse 7C regions, in close proximity to NDN / Ndn. By northern blot analysis we did not detect any expression of MAGEL2 / Magel2 but by RT-PCR analysis, specific expression was detected in fetal and adult brain and in placenta. Both genes are intronless with tandem direct repeat sequences contained within a CpG island in the 5'-untranscribed region. The transcripts encode putative proteins that are homologous to the MAGE proteins and NDN. Moreover, MAGEL2 / Magel2 are expressed only from the paternal allele in brain, suggesting a potential role in the aetiology of PWS and its mouse model, respectively.
Stereospecific Total Synthesis of Somocystinamide A (2008)

The first total synthesis of somocystinamide A, a disulfide dimer with extremely labile enamide functional groups, was accomplished in a concise and stereospecific manner. Somocystinamide A is reported to possess exceptionally potent antiangiogenic and tumoricidal activities. The current work should enable further pharmacological investigation of this important natural product.
ELECTROCHEMICALLY PREPARED POLYELECTROLYTE COMPLEX OF POLYPYRROLE AND A FLAVIN-CONTAINING POLYANION - USE AS A BIOSENSOR (1992)

Pyrrole was polymerized electrochemically in an aqueous medium on a platinum electrode in the presence of a polyanion, containing covalently bound flavin units. Depending on the applied potential the polypyrrole-films thus formed were powdery and non-adherent (V &lt;700 mV), smooth and adherent (700 mV &lt;V &lt;1000 mV) or brittle and uneven (V &gt; 1000 mV). Besides the applied potential, medium pH and added low molar mass salt influenced the morphology and composition of the PPy-layer. The flavin-containing polyanion was incorporated in the film as a dopant. Depending on the medium pH and amount of low molar mass salt added, the film formed by this method contained various amounts of polymer-bound flavin. Cyclic voltammograms confirmed the presence of electrochemically active flavin in the layer. The oxidation of 1-benzyl-1,4-dihydronicotinamide (BNAH) was used as a model reaction to test the catalytic activity of the immobilized flavin. The modified electrode showed fast current response on addition of BNAH, not only at an applied potential of 0.9 V (oxidation of H2O2) but also in the absence of oxygen at 0.3 V. This might indicate that a direct transfer of electrons takes place between the flavin units and the (PPy-)electrode. Cycling of the PPy-film through its reduced and oxidized state does not lead to any loss of the flavin containing polyanion. In the case of low molar mass flavin-containing dopants most of the flavin is released from the film upon reduction of the PPy.
Cardiac magnetic resonance imaging in hemodialysis patients (2009)

LVH in dialysis patients has a unique MRI appearance which is distinct from either cLVH or eLVH, with profound LV thickening and moderate dilation of the ventricular cavity. A 9-month course of spironolactone therapy did not affect morphology.
Microstructure of monoplacophora (mollusca) shell examined by low‐voltage field emission scanning electron and atomic force microscopy (2003)

The shell of Micropilina arntzi (Mollusca: Monoplacophora), a primitive molluscan class, was examined by using field emission scanning electron microscopy (FESEM) at low voltage and atomic force microscopy (AFM). The use of these two techniques allowed the observation of fine details of Micropilina arntzi shell and contributed to bring new features concerning the study of molluscan shell microtexture. Imaging with low-voltage FESEM provided well-defined edge contours of shell structures, while analyzing the sample with AFM gave information about the step height of stacked internal structures as well as the dimension of the particles present in their surface at a nanometric level. The shell microstructure of Monoplacophora species presents different patterns and may be a taxonomic implication in the systematic studies of the group.
Performance evaluation of MIMO satellite multiple-relay multi-user fading channels (2015)

In this paper, a novel transmitting scheme for multiple-input multiple-output (MIMO) satellite relay-based multi-user multi-beam communications is proposed. It is considered that multiple terrestrial relay nodes employ amplify-and-forward (A-F) relaying and intend to improve the reliability and spectral efficiency of satellite radio links. Zero forcing (ZF) and minimum mean square error (MMSE) signal detection techniques are employed, which have been well-established in terrestrial wireless communication systems. Numerical results are provided to quantify the performance gain of the proposed system configuration in terms of the bit-error-rate (BER) and the channel capacity.
How to Teach a 14-Week Robotic Process Automation (RPA) Course for Accounting Students (2022)

ABSTRACT This learning strategy provides accounting faculty with a detailed course design and materials for a 3-credit, 14-week RPA course at the graduate level. This learning strategy is valuable in four respects. First, it leverages existing materials in the public domain and provides accounting faculty with a potential framework for using these materials to create an RPA course. Second, it teaches students RPA concepts and provides them with hands-on skills. Third, although it features a stand-alone RPA course, specific modules from this course can also be used as non-technical tutorials and be integrated into existing accounting courses. Last, it features resource and experience sharing based on the course implementation. Overall, this learning strategy adds an alternative resource to accounting faculty considering teaching RPA.
Modulation Of Sympathetic Nervous, Renin Angiotensin And Kallikrein Kinin Systems On Youth Obesity (2012)

The aim of this study was to evaluate the relationship between obesity and Sympathetic Nervous (SNS), Renin Angiotensin (RAS) and Kallikrein Kinin (KKS) Systems. Subjects were divided in groups: 43 normal weight (NW), 14 overweight (OV), 37 obese (OB) and 10 MO (MO). The Ang I, Ang II, Ang‐(1–7), Bradykinin (BK), Vasopressin (VP), norepinephrine (NE), epinephrine (EP), serotonin (SE) plasmatic levels had been measured by HPLC. Ang (1–7) levels were lower in MO and OB compared with NW (0.06±0.04; 0.24±0.17 and 0.52±0.21nmol/mL). Ang I levels were higher in MO compared with NW (0.06±0.03; 0.03±0.02). OB had higher values of VP than NW (0.107±0.0217; 0.087±0.016ng/mL). OB had higher values of EP and NE than NW (48.3±20.3 vs 34.7±17.2 and 85.6±27.9 vs 45.9±28.3 pg/mL respectively). The NW had higher concentration of SE than the OV (281.2±113.0 vs 200.1±117.1 ng/mL). MO had lower BK levels than NW (0.367 vs 0.885). Our results showed a reduction of Ang (1–7) and increased of Ang I associated with weight gain in adolescents suggesting a modulation of ACE2 and NEP. According to our results, obesity in youth seems to be related with high levels of EP, NE, blood pressure and low Ang (1–7). These alterations in the SNS, RAS and KKS, associated with low levels of Ang 1–7 and BK may contribute to the development of hypertension in obese adolescents, since these can resulting in cardiovascular target organ damage such as the heart, the vascular wall and the kidney.
Reference values and sex differences in absolute and relative kidney size. A Swiss autopsy study (2020)

Absolute and relative renal weights were both smaller in women. This is in line with recent studies stating that nephron numbers are also lower in women. Relative renal length was longer in women, suggesting that female kidneys have a more elongated shape. In comparison with older autopsy studies, renal weight appears to be stable over time.
Age‐Related Decrease in the Schaffer Collateral‐Evoked EPSP in Awake, Freely, Behaving Rats (2000)

Synaptic response size in the CA1 region of the hippocampus in aged rats is reduced for a given stimulus intensity, compared with that elicited in young rats. Consistent with the in vitro findings of reduced Schaffer collateral-evoked CA1 EPSPs in old rats, the population currents evoked to iontophoretically applied AMPA are also smaller relative to the presynaptic fiber potential amplitude. On the other hand, the size of the presynaptic fiber potential and amplitude of unitary intra-cellularly recorded EPSP responses do not change across age in the CA1 region. These electrophysiological findings are consistent with the hypothesis that old rats have fewer functional synaptic contacts per Schaffer collateral axon than do young rats. The possibility that this age change arises as a result of a differential tissue recovery response to in vitro preparation was examined in the present study. CA1 presynaptic fiber potential and EPSP amplitudes evoked by the stimulation of Schaffer collateral afferents were studied in intact, freely behaving young and old rats. We confirmed in vivo the pattern of electrophysiophysiological results previously reported in vitro and found significant correlations between the synaptic response amplitudes and the accuracy of spatial behavior in the Morris swim task. The data suggest that changes in functional connectivity of old rats may be a significant contributor to cognitive changes during aging.
ChemInform Abstract: NMR Conformational Analysis (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
BLER-based Adaptive Q-learning for Efficient Random Access in NOMA-based mMTC Networks (2021)

The ever-increasing number of machine-type communications (MTC) devices and the limited available radio resources are leading to a crucial issue of radio access network (RAN) congestion in upcoming 5G and beyond wireless networks. Thus, it is crucial to investigate novel techniques to minimize RAN congestion in massive MTC (mMTC) networks while taking the underlying short-packet communications (SPC) into account. In this paper, we propose an adaptive Q-learning (AQL) algorithm based on block error rate (BLER), an important metric in SPC, for a non-orthogonal multiple access (NOMA) based mMTC system. The proposed method aims to efficiently accommodate MTC devices to the available random access (RA) slots in order to significantly reduce the possible collisions, and subsequently to enhance the system throughput. Furthermore, in order to obtain more practical insights on the system design, the scenario of imperfect successive interference cancellation (ISIC) is considered as compared to the widely-used perfect SIC assumption. The performance of the proposed AQL method is compared with the recent Q-learning solutions in the literature in terms of system throughput over a range of parameters such as the number of devices, blocklength, and residual interference caused by ISIC, along with its convergence evaluation. Our simulation results illustrate the superiority of the proposed method over the existing techniques, in the scenarios where the number of devices is higher than the number of available RA time-slots.
Circuit for Shor's algorithm using 2n+3 qubits (2003)

We try to minimize the number of qubits needed to factor an integer of n bits using Shor's algorithm on a quantum computer. We introduce a circuit which uses 2n+3 qubits and O(n^3 lg(n)) elementary quantum gates in a depth of O(n^3) to implement the factorization algorithm. The circuit is computable in polynomial time on a classical computer and is completely general as it does not rely on any property of the number to be factored.
Cerivastatin Improves Insulin Sensitivity and Insulin Secretion in Early-State Obese Type 2 Diabetes (2002)

In a double-blind, placebo-controlled, randomized crossover study, 15 stable mild hyperglycemic patients without treatment and with features of metabolic syndrome were treated with cerivastatin (0.4 mg/day) or placebo for 3 months. The insulin sensitivity index during the euglycemic-hyperinsulinemic clamp (EHC; 5.4 mmol/l; 80 mU x m(-2) x min(-1)) was increased by cerivastatin treatment (66.39 +/- 3.9 nmol x lean body mass [LBM](-1) x min(-1) x pmol(-1) x l(-1)) as compared with placebo (58.37 +/- 3.69 nmol x LBM(-1) x min(-1) x pmol(-1) x l(- 1); P < 0.01) by 13.7%. Glucose oxidation during EHC was significantly higher with statin treatment (16.1 +/- 1.37 micromol x LBM(-1) x min(-1)) as compared with placebo (14.58 +/- 1.48 micromol x LBM(-1) x min(-1); P < 0.05). During hyperinsulinemia (approximately 800 pmol/l) in EHC steady-state, lipid oxidation was significantly decreased and respiratory quotient was significantly increased with statin treatment (0.33 +/- 0.05 mg x LBM(-1) x min(- 1), 0.94 +/- 0.01) as compared with placebo (0.48 +/- 0.06 mg x LBM(-1) x min(-1), 0.91 +/- 0.01; P < 0.01 and P < 0.05, respectively). During statin treatment, the first-phase insulin response increased from 2.07 +/- 0.28 to 2.82 +/- 0.38 pmol x l(-1) x pmol(-1) (P < 0.05). The second phase of insulin responses examined by C-peptide and insulin levels averaged during the hyperglycemic clamp (20 mmol/l) was unchanged. In conclusion, this study demonstrates that 0.4 mg cerivastatin therapy improves first-phase insulin secretion and increases insulin-mediated glucose uptake and respiratory quotient in the early state of obese type 2 diabetes.
Dynamic packet aggregation to solve performance anomaly in 802.11 wireless networks (2006)

In the widely used 802.11 standard, the so-called performance anomaly is a well-known issue. Several works have tried to solve this problem by introducing mechanisms such as packet fragmentation, backoff adaptation, or packet aggregation during a fixed time interval. In this paper, we propose a novel approach solving the performance anomaly problem by packet aggregation using a dynamic time interval, which depends on the busy time of the wireless medium. Our solution differs from other proposition in the literature because of this dynamic time interval, which allows increasing fairness, reactivity, and in some cases efficiency. In this article, we emphasize the performance evaluation of our proposal.
Reaction of cyclopropenone ketals with alcohols (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReaction of cyclopropenone ketals with alcoholsG. B. Butler, K. H. Herring, P. L. Lewis, V. V. Sharpe III, and R. L. VeazeyCite this: J. Org. Chem. 1977, 42, 4, 679–682Publication Date (Print):March 1, 1977Publication History Published online1 May 2002Published inissue 1 March 1977https://doi.org/10.1021/jo00424a022RIGHTS & PERMISSIONSArticle Views508Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (595 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Raman Scattering From TMTSF-Salts (1982)

Abstract Experimental results for Raman scattering from TSeF, TMTSF-D12, (TMTSF)2PF6 and (TMTSF)2AsF6 excited with blue-green laser light at liquid nitrogen temperature are reported. A strong resonance effect for excitation of TMTSF with 4579 Å was observed and an assignment for the ag modes was obtained by comparison with results from TTF. Methyl group modes were identified at 328 cm−1, 472 cm−1 and 916 cm−1, respectively. Charging the TMTSF molecule resulted in a strong frequency shift of -122 cm−1 and -76 cm−1 for the agu2 mode, respectively. A study of the temperature dependence of the scattering from molecular modes between 2 K and 300 K did not reveal any correlation with the phase transitions in the conducting compounds.