gebhart/patrepeval huggingface dataset:
Aeronautical ad hoc networks (2006)

There has been an enormous growth in mobile ad hoc networks (MANETs) in land based small to medium size networks with relatively strict power and resources. In this paper the concept of ad hoc networking between aircraft is introduced, which can be considered as a novel approach in increasing the data rate and practicality of future in-flight broadband Internet access. This method also reduces the Internet traffic load on satellite nodes and also propagation delay for real-time traffic transmissions, by effectively bypassing the satellite link for nonreal time data. A dynamic routing algorithm is also proposed for efficient routing in this kind of system. A new cost metric for increasing path duration is introduced to assist routing in the proposed ad hoc network
[Meproscillarin, a new semisynthetic cardiac glycoside/chemistry and physical properties (author's transl)]. (1978)

14-Hydroxy-3beta-[4-O-methyl-alpha-L-rhamnopyranosyl)oxy]-14beta-bufa-4,20,22-trienolide (meproscillarin) is a new semisynthetic glycoside for the therapy of cardiac insufficiency. The preparation from proscillaridin and the chemical and physical properties are described.
DNA minor groove-binding ligands: a different class of mammalian DNA topoisomerase I inhibitors. (1993)

A number of DNA minor groove-binding ligands (MGBLs) are known to exhibit antitumor and antimicrobial activities. We show that DNA topoisomerase (Topo) I may be a pharmacological target of MGBLs. In the presence of calf thymus Topo I, MGBLs induced limited but highly specific single-strand DNA breaks. The 3' ends of the broken DNA strands are covalently linked to Topo I polypeptides. Protein-linked DNA breaks are readily reversed by a brief heating to 65 degrees C or the addition of 0.5 M NaCl. These results suggest that MGBLs, like camptothecin, abort Topo I reactions by trapping reversible cleavable complexes. The sites of cleavage induced by MGBLs are distinctly different from those induced by camptothecin. Two of the major cleavage sites have been sequenced and shown to be highly A + T-rich, suggesting the possible involvement of a Topo I-drug-DNA ternary complex at the sites of cleavage. Different MGBLs also exhibit varying efficiency in inducing Topo I-cleavable complexes, and the order of efficiency is as follows: Hoechst 33342 and 33258 >> distamycin A > berenil > netropsin. The lack of correlation between DNA binding and cleavage efficiency suggest that, in addition to binding to the minor grooves of DNA, MGBLs must also interact with Topo I in trapping Topo I-cleavable complexes.
RRAM-Based STDP Network for Edge Computing in Wearable/Implantable Devices (2021)

With the technology advancement of wearable and implantable devices, the demand is increasing for low power computing circuits that allow processing of the acquired data on the edge to shorten the response time and save data bandwidth. Resistive-memory-based computing circuits have attracted broad interests due to their potential to implement low-power computing-in-memory macros and neuromorphic processors. This paper explores the hardware implementation of an artificial spiking neural network with the capability of online STDP learning by using a low-power analog CMOS circuit and a resistive random-access memory (RRAM) device. We examined the low power characteristics of the proposed circuit and its potential use for in situ signal processing, which holds promise for neural recording applications using implantable devices such as neural probes.
A high-speed message-driven communication architecture (1988)

The performance of a message-passing multiple instruction multiple data (MIMD) concurrent computer depends in large part on the communication processing overhead. A high-speed communication architecture is proposed for a hypercube-type supercomputer to attain the specific goals of message-driven processing. These goals include: direct hardware execution of messages, queueing of messages (using various paradigms), adaptive message routing, and special local registers for fast context switching. A hyperswitch network capable of high-speed switching is used to perform message routing. Available communication paths are pruned by the routing algorithm in response to congestion within the network to evaluate the best-first available path between any two nodes. Simulation results show that this architecture reduces message reception latency by two to three orders of magnitude when compared to commercial hypercube systems. This communication architecture extends the application of parallel systems to supercomputer problems that place heavy demand on the communication network for high bandwidth, low latency, and non-local communication. Detailed simulation studies for the proposed communication architecture are presented.
Nanomagnetic logic design approach for area and speed efficient adder using ferromagnetically coupled fixed input majority gate (2019)

In this letter, we introduce the magnetic quantum-dot cellular automata (MQCA) based area and speed efficient design approach for nanomagnetic full adder implementation. We exploited the physical properties of three input MQCA majority gate (MG), where the fixed input of the MG is coupled ferromagnetically to one of the primary input operands. Subsequently we propose a design methodology, mapping logic and micromagnetic software implementation, validation of the binary full adder architecture built using two-three inputs MQCA MGs. In addition, we also analyzed our proposed design for switching errors to ensure bit stability and reliability. Our proposed design leads to ∼36%-69% reduction in the number of nanomagnets, ∼50%-75% reduction in the number of clock cycles and ∼33%-50% reduction in the number of MG operations required for the binary full adder implementation compared to the state of art designs.
Designing a curriculum for junior entrepreneurs (2014)

Anthony David looks at the benefits of embedding enterprise education in the school curriculum and making it part of a whole-school approach.
Theory of Equilibrium Flux Lattices in Unconventional Superconductors (1997)

We investigate equilibrium flux lattice structures in superconductors with unconventional order parameters, such as high- ${T}_{c}$ cuprates, using a generalized London model with nonlocal electrodynamics derived from a simple microscopic model. We find a rich phase diagram containing triangular, centered rectangular, and square lattices with various orientations relative to the ionic lattice, as a function of magnetic field and temperature.
Age-related Multiscale Changes in Brain Signal Variability in Pre-task versus Post-task Resting-state EEG (2016)

Recent empirical work suggests that, during healthy aging, the variability of network dynamics changes during task performance. Such variability appears to reflect the spontaneous formation and dissolution of different functional networks. We sought to extend these observations into resting-state dynamics. We recorded EEG in young, middle-aged, and older adults during a "rest-task-rest" design and investigated if aging modifies the interaction between resting-state activity and external stimulus-induced activity. Using multiscale entropy as our measure of variability, we found that, with increasing age, resting-state dynamics shifts from distributed to more local neural processing, especially at posterior sources. In the young group, resting-state dynamics also changed from pre- to post-task, where fine-scale entropy increased in task-positive regions and coarse-scale entropy increased in the posterior cingulate, a key region associated with the default mode network. Lastly, pre- and post-task resting-state dynamics were linked to performance on the intervening task for all age groups, but this relationship became weaker with increasing age. Our results suggest that age-related changes in resting-state dynamics occur across different spatial and temporal scales and have consequences for information processing capacity.
Leader selection for optimal network coherence (2010)

We consider the problem of leader-based distributed coordination in networks where agents are subject to stochastic disturbances, but where certain designated leaders are immune to those disturbances. Specifically, we address the effect of leader selection on the coherence of the network, defined in terms of an H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> norm of the system. This quantity captures the level of agreement of the nodes in the face of the external disturbances. We show that network coherence depends on the eigenvalues of a principal submatrix of the Laplacian matrix, and we formulate an optimization problem to select the set of leaders that results in the highest coherence. As this optimization problem is combinatorial in nature, we also present several greedy algorithms for leader selection that rely on more easily computable bounds of the H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> norm and the eigenvalues of the system. Finally, we illustrate the effectiveness of these algorithms using several network examples.
Transfer Function Analysis of Constrained, Distributed Piezoelectric Vibration Energy Harvesting Beam Systems (2018)

This paper presents a novel formulation and exact solution of the frequency response function (FRF) of vibration energy harvesting beam systems by the distributed transfer function method (TFM). The method is applicable for coupled electromechanical systems with nonproportional damping, intermediate constraints, and nonclassical boundary conditions, for which the system transfer functions are either very difficult or cumbersome to obtain using available methods. Such systems may offer new opportunities for optimized designs of energy harvesters via parameter tuning. The proposed formulation is also systematic and amenable to algorithmic numerical coding, allowing the system response and its derivatives to be computed by only simple modifications of the parameters in the system operators for different boundary conditions and the incorporation of feedback control principles. Examples of piezoelectric energy harvesters with nonclassical boundary conditions and intermediate constraints are presented to demonstrate the efficacy of the proposed method and its use as a design tool for vibration energy harvesters via tuning of system parameters. The results can also be used to provide benchmarks for assessing the accuracies of approximate techniques.
Picture Archiving and Communication Systems (2011)

Picture archiving and communication systems (PACS) are highly versatile data storage and retrieval systems that facilitate the transfer of digital images and patient data throughout a healthcare enterprise. Typically, they process images from diagnostic imaging modalities and are interfaced to radiology information systems (RISs) and hospital information systems (HISs) to help create a single patient record and improve overall workflow. For this Update Evaluation, we tested eight PACS from eight major suppliers. Ideally, a PACS should allow the facility to achieve a fully automated workflow, in which patient data could move seamlessly from one system to another in a single electronic medical record. Although our testing found that this ideal has not yet been realized, many of the evaluated systems have taken significant steps in that direction. Three of the systems covered in this issue were originally tested for our November 2000 Evaluation. Because PACS technology evolves so rapidly, we haven't simply provided updated data on these three systems, as we customarily would for an Update Evaluation. Instead, we have reexamined the systems from top to bottom and are presenting the results in brand-new Product Profiles, alongside the profiles for the five other systems evaluated here for the first time.
Performance of two‐pole bandpass filters photodefined on double‐sided Y‐Ba‐Cu‐O AND Tl‐Ba‐Ca‐Cu‐O thin films (1993)

Abstract The performance of 7.3‐GHz two‐pole bandpass filters (5% bandwidth) fabricated on double‐sided Y‐Ba‐Cu‐O and Tl‐Ba‐Ca‐Cu‐O thin films deposited on LaAlO 3 is discussed. At 77 K, the Tl‐Ba‐Ca‐Cu‐O and Y‐Ba‐Cu‐O superconducting filters exhibited minimum passband insertion losses of 0.3 and 1.2 dB, respectively. An insertion loss of 3.4 dB was measured for an all‐gold filter at 77 K. © 1993 John Wiley &amp; Sons, Inc.
Functional genome annotation ofDrosophilaseminal fluid proteins using transcriptional genetic networks (2011)

Predicting functional gene annotations remains a significant challenge, even in well-annotated genomes such as yeast and Drosophila. One promising, high-throughput method for gene annotation is to use correlated gene expression patterns to annotate target genes based on the known function of focal genes. The Drosophila melanogaster transcriptome varies genetically among wild-derived inbred lines, with strong genetic correlations among the transcripts. Here, we leveraged the genetic correlations in gene expression among known seminal fluid protein (SFP) genes and the rest of the genetically varying transcriptome to identify 176 novel candidate SFPs (cSFPs). We independently validated the correlation in gene expression between seven of the cSFPs and a known SFP gene, as well as expression in male reproductive tissues. We argue that this method can be extended to other systems for which information on genetic variation in gene expression is available.
Noninvasive Cardiac Monitoring for Detecting Paroxysmal Atrial Fibrillation or Flutter After Acute Ischemic Stroke (2007)

Screening consecutive patients with ischemic stroke with routine Holter monitoring will identify new atrial fibrillation/flutter in approximately one in 20 patients. Although based on limited data, extended duration of monitoring may improve the detection rate. Further research is required before definitive recommendations can be made.
Rb/E2F1 Regulates the Innate Immune Receptor Toll-Like Receptor 3 in Epithelial Cells (2012)

Tumor suppressor genes regulate the antiviral host defense through molecular mechanisms that are not yet well explored. Here, we show that the tumor suppressor retinoblastoma (Rb) protein positively regulates Toll-like receptor 3 (TLR3) expression, the sensing receptor for viral double-stranded RNA and poly(I · C). TLR3 expression was lower in Rb knockout (Rb(-/-)) mouse embryonic fibroblasts (MEF) and in mammalian epithelial cells transfected with Rb small-interfering RNA (siRNA) than in control cells. Consequently, induction of cytokines interleukin-8 and beta interferon after poly(I · C) stimulation was impaired in Rb(-/-) MEF and Rb siRNA-transfected cells compared to controls. TLR3 promoter analysis showed that Rb modulates the transcription factor E2F1, which directly binds to the proximal promoter of TLR3. Exogenous addition of E2F1 decreased TLR3 promoter activity, while Rb dose dependently curbed the effect of E2F1. Interestingly, poly(I · C) increased the Rb expression, and the poly(I · C)-induced TLR3 expression was impaired in Rb-depleted cells, suggesting the importance of Rb in TLR3 induction by poly(I · C). Together, these data indicated that E2F1 suppresses TLR3 transcription, but during immune stimulation, Rb is upregulated to block the inhibitory effect of E2F1 on TLR3, highlighting a role of Rb-E2F1 axis in the innate immune response in epithelial cells.
An Integrated Micro- and Macroarchitectural Analysis of the Drosophila Brain by Computer-Assisted Serial Section Electron Microscopy (2010)

The analysis of microcircuitry (the connectivity at the level of individual neuronal processes and synapses), which is indispensable for our understanding of brain function, is based on serial transmission electron microscopy (TEM) or one of its modern variants. Due to technical limitations, most previous studies that used serial TEM recorded relatively small stacks of individual neurons. As a result, our knowledge of microcircuitry in any nervous system is very limited. We applied the software package TrakEM2 to reconstruct neuronal microcircuitry from TEM sections of a small brain, the early larval brain of Drosophila melanogaster. TrakEM2 enables us to embed the analysis of the TEM image volumes at the microcircuit level into a light microscopically derived neuro-anatomical framework, by registering confocal stacks containing sparsely labeled neural structures with the TEM image volume. We imaged two sets of serial TEM sections of the Drosophila first instar larval brain neuropile and one ventral nerve cord segment, and here report our first results pertaining to Drosophila brain microcircuitry. Terminal neurites fall into a small number of generic classes termed globular, varicose, axiform, and dendritiform. Globular and varicose neurites have large diameter segments that carry almost exclusively presynaptic sites. Dendritiform neurites are thin, highly branched processes that are almost exclusively postsynaptic. Due to the high branching density of dendritiform fibers and the fact that synapses are polyadic, neurites are highly interconnected even within small neuropile volumes. We describe the network motifs most frequently encountered in the Drosophila neuropile. Our study introduces an approach towards a comprehensive anatomical reconstruction of neuronal microcircuitry and delivers microcircuitry comparisons between vertebrate and insect neuropile.
Interdisciplinary Education to Integrate Pathology and Epidemiology: Towards Molecular and Population-Level Health Science (2012)

In recent decades, epidemiology, public health, and medical sciences have been increasingly compartmentalized into narrower disciplines. The authors recognize the value of integration of divergent scientific fields in order to create new methods, concepts, paradigms, and knowledge. Herein they describe the recent emergence of molecular pathological epidemiology (MPE), which represents an integration of population and molecular biologic science to gain insights into the etiologies, pathogenesis, evolution, and outcomes of complex multifactorial diseases. Most human diseases, including common cancers (such as breast, lung, prostate, and colorectal cancers, leukemia, and lymphoma) and other chronic diseases (such as diabetes mellitus, cardiovascular diseases, hypertension, autoimmune diseases, psychiatric diseases, and some infectious diseases), are caused by alterations in the genome, epigenome, transcriptome, proteome, metabolome, microbiome, and interactome of all of the above components. In this era of personalized medicine and personalized prevention, we need integrated science (such as MPE) which can decipher diseases at the molecular, genetic, cellular, and population levels simultaneously. The authors believe that convergence and integration of multiple disciplines should be commonplace in research and education. We need to be open-minded and flexible in designing integrated education curricula and training programs for future students, clinicians, practitioners, and investigators.
Orthogonal Beamforming for SDMA Downlink with Limited Feedback (2007)

On a multi-antenna downlink channel, separation of multiple users by transmit beamforming enables simultaneous transmission from the base station to the users, resulting in high sum throughput. This paper proposes and analyzes a practical algorithm for joint scheduling and orthogonal beamforming, which is enabled by feedback of quantized channel state information (CSI). In this approach, each user quantizes CSI using a codebook comprised of multiple orthonormal vector sets and sends back quantized CSI. Using feedback CSI, the base station jointly selects a set of orthogonal beamforming vectors and schedules a subset of feedback users for downlink transmission such that the throughput is maximized. For moderate to large numbers of users, the proposed algorithm achieves higher sum capacities than the conventional ones.
Recombinant Covalently Closed Circular Hepatitis B Virus DNA Induces Prolonged Viral Persistence in Immunocompetent Mice (2014)

It remains crucial to develop a laboratory model for studying hepatitis B virus (HBV) chronic infection. We hereby produced a recombinant covalently closed circular DNA (rcccDNA) in view of the key role of cccDNA in HBV persistence. A loxP-chimeric intron was engineered into a monomeric HBV genome in a precursor plasmid (prcccDNA), which was excised using Cre/loxP-mediated DNA recombination into a 3.3-kb rcccDNA in the nuclei of hepatocytes. The chimeric intron was spliced from RNA transcripts without interrupting the HBV life cycle. In cultured hepatoma cells, cotransfection of prcccDNA and pCMV-Cre (encoding Cre recombinase) resulted in accumulation of nuclear rcccDNA that was heat stable and epigenetically organized as a minichromosome. A mouse model of HBV infection was developed by hydrodynamic injection of prcccDNA. In the presence of Cre recombinase, rcccDNA was induced in the mouse liver with effective viral replication and expression, triggering a compromised T-cell response against HBV. Significant T-cell hyporesponsiveness occurred in mice receiving 4 μg prcccDNA, resulting in prolonged HBV antigenemia for up to 9 weeks. Persistent liver injury was observed as elevated alanine transaminase activity in serum and sustained inflammatory infiltration in the liver. Although a T-cell dysfunction was induced similarly, mice injected with a plasmid containing a linear HBV replicon showed rapid viral clearance within 2 weeks. Collectively, our study provides an innovative approach for producing a cccDNA surrogate that established HBV persistence in immunocompetent mice. It also represents a useful model system in vitro and in vivo for evaluating antiviral treatments against HBV cccDNA. Importance: (i) Unlike plasmids that contain a linear HBV replicon, rcccDNA established HBV persistence with sustained liver injury in immunocompetent mice. This method could be a prototype for developing a mouse model of chronic HBV infection. (ii) An exogenous intron was engineered into the HBV genome for functionally seamless DNA recombination. This original approach could be also extended to other viral studies. (iii) rcccDNA was substantially induced in the nuclei of hepatocytes and could be easily distinguished by its exogenous intron using PCR. This convenient model system affords the opportunity to test antivirals directly targeting HBV cccDNA.
ChemInform Abstract: A Rapid Entry into Podophyllotoxin Congeners: Synthesis of Justicidin B (VIIIa). (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Proton-enabled biomimetic stabilization of small-molecule organic cathode in aqueous zinc-ion batteries (2022)

Biomimetic strategy was applied to enhance the stability of a small molecule organic cathode, leading to the formation of hydrogen bonds that stabilize the structure and activate pathways for ultrafast proton transfer in aqueous zinc-ion batteries.
Gas permeable hydrophobic material (2023)

Hydrophobic filter materials, methods of making them, and their use in various industrial applications are presented. In an example, thermally stable, gas permeable hydrophobic filters which maintain their integrity upon exposure to elevated temperature, radiation, acid, or all are described.