gebhart/patrepeval huggingface dataset:
Polysulfides do not mimic the sulfide-induced acceleration of Ca<sub>v</sub>3.2 T-type Ca<sup>2+</sup> channel activity: possible involvement of distinct affinity to zinc (2022)

Sulfides, such as Na2S and NaHS, enhance Cav3.2 T-type Ca2+ channel activity, thereby promoting pain signals. We hypothesize that, as does L-Cys, a thiol compound, sulfides might interact with zinc binding to His-191 in Cav3.2 and cancel the zinc-induced channel inhibition. On the other hand, the effects of polysulfides, such as Na2S3 and Na2S4, on Cav3.2 function have yet to be investigated. Thus, we compared the effects of sulfides and polysulfides on T-channel-dependent currents (T-currents) in human Cav3.2-expressing HEK293 cells, and analyzed possible involvement of sulfide-zinc interaction. Na2S and NaHS at 3-30 µM rapidly caused remarkable and persistent increase in T-currents. In contrast, Na2S3 and Na2S4 in the same range caused only slight and transient T-current increase, followed slowly by its decrease below the baseline. In the presence of tricine, a weak Zn2+ chelator, T-currents increased, which was reversed by ZnCl2 at 30 µM. The increased T-currents in the presence of tricine was not altered by Na2S at 30 µM, but augmented by addition of Na2S following ZnCl2. Our data suggest that the sulfide-induced enhancement of Cav3.2 function involves the interaction of sulfide with Zn2+ possibly binding to His-191 in Cav3.2, and cannot be mimicked by polysulfides.
Single-Blind Detection, Localization, and Quantification of Methane Emissions Using Continuous Path-Integrated Column Measurements (2023)

Path-integrated column measurements with a laser absorption-based measurement system have been used to detect, locate, and quantify methane emissions from a series of single-blind controlled releases with no prior knowledge of timing, locations, or release rates. System performance was evaluated against metrics defined in the Continuous Monitoring Protocol established by the Colorado State University Methane Emissions Technology Evaluation Center (METEC). This protocol allows more direct comparison of system performance between disparate measurement technologies and is transferable to any test facility. To the authors’ knowledge, this work represents the first time the protocol has been directly applied at a test facility other than METEC. This experiment differs from similar tests where releases were conducted from equipment units at fixed locations at METEC by instead conducting releases at random locations anywhere within the central 0.18 km2 of a 0.35 km2 unobstructed test site. The releases were much shorter in duration than those conducted in similar testing at METEC. The system detected 25 of 42 releases with metered rates of 0.17–2.15 kg h−1. The minimum detected emissions rate was 0.22 kg h−1, and the system demonstrated a 100% detection rate for releases ≥0.65 kg h−1 and average wind speed &lt;5 m s−1. The test site was subdivided into 20 boxes (109 × 83 m each), and the correct release box was identified in 9 cases, another 9 detections were localized to an adjacent box, and the remaining 7 were attributed elsewhere within the field. The average estimated emission rate bias was −6.1%. The 90% detection limit was 0.89 kg h−1, while the wind-normalized detection limit was 0.44 (kg h−1) (m s−1)−1.
Angiogenic growth factors in the diagnosis and prediction of pre-eclampsia (2011)

The pathogenesis of pre-eclampsia is still not completely known; however, in the recent decade, there have been tremendous research efforts leading to impressive results highlighting the role of a disturbed angiogenic balance as one of the key features of the disease. Numerous studies have shown the key role of the placenta in the pathogenesis of pre-eclampsia. A shift in the sFlt-1 (soluble Fms-like tyrosine kinase-1)/PlGF (placental growth factor) ratio is associated with the disease. Although pre-eclampsia seems to be a clearly defined disease, clinical presentation, and particularly the dynamics of the clinical course, can vary enormously. The only available tools to diagnose pre-eclampsia are blood pressure measurement and urine protein sampling. However, these tools have a low sensitivity and specificity regarding the prediction of the course of the disease or maternal and perinatal outcomes. The only cure for the disease is delivery, although a timely diagnosis helps in decreasing maternal and fetal morbidity and mortality. The sFlt1/PlGF ratio is able to give additional valuable information on the status and progression of the disease and is apt to be implemented in the diagnostic algorithm of pre-eclampsia. In the present review, we aim to provide an overview of the vast literature on angiogenesis and anti-angiogenesis factors in pre-eclampsia that have been published over the last decade. We introduce work from basic research groups who have focused on the pathophysiological basis of the disease. Furthermore, we review studies with a clinical focus in which the sFlt-1/PlGF ratio has been analysed along with other candidates for routine clinical assessment of pre-eclampsia.
[Application of fiducial wavelength method in processing spectra of turbid media]. (2006)

In the present paper, the authors analyzed the absorption and scattering effects of changing the solution concentration on the spectra, and dealed with the wavelength, where the absorption and scattering effects counteract completely, the fiducial wavelength method can eliminate the perturbation from shift of instrument and temperature, and also can improve predicting ability of the model. The result of utilizing this method to process the spectral data of two sample sets, i. e. intralipid solution and plasma solution with different level glucose, has verified that fiducial wavelength method can improve correlation coefficient and decrease RMSEP of predicting model.
Prospective epidemiologic study of the outcome and cost‐effectiveness of antenatal screening to detect neonatal alloimmune thrombocytopenia due to anti‐HPA‐1a (2005)

Our data suggest that severe HPA-1a NAIT is underdiagnosed in the absence of routine antenatal screening. Serious bleeding complications and ICH, however, occur less frequently in first cases of NAIT than suspected from the literature, and the costs of screening and possible intervention must be balanced against the procedural risks.
Solution Assembly of Organized Carbon Nanotube Networks for Thin-Film Transistors (2009)

Ultrathin, transparent electronic materials consisting of solution-assembled nanomaterials that are directly integrated as thin-film transistors or conductive sheets may enable many new device structures. Applications ranging from disposable autonomous sensors to flexible, large-area displays and solar cells can dramatically expand the electronics market. With a practical, reliable method for controlling their electronic properties through solution assembly, submonolayer films of aligned single-walled carbon nanotubes (SWNTs) may provide a promising alternative for large-area, flexible electronics. Here, we report SWNT network TFTs (SWNTntTFTs) deposited from solution with controllable topology, on/off ratios averaging greater than 10(5), and an apparent mobility averaging 2 cm(2)/V.s, without any pre- or postprocessing steps. We employ a spin-assembly technique that results in chirality enrichment along with tunable alignment and density of the SWNTs by balancing the hydrodynamic force (spin rate) with the surface interaction force controlled by a chemically functionalized interface. This directed nanoscale assembly results in enriched semiconducting nanotubes yielding excellent TFT characteristics, which is corroborated with mu-Raman spectroscopy. Importantly, insight into the electronic properties of these SWNT networks as a function of topology is obtained.
Streaming, low-latency communication in on-line trading systems (2010)

This paper presents and evaluates the performance of a prototype of an on-line OPRA data feed decoder. Our work demonstrates that, by using best-in-class commodity hardware, algorithmic innovations and careful design, it is possible to obtain the performance of custom-designed hardware solutions. Our prototype system integrates the latest Intel Nehalem processors and Myricom 10 Gigabit Ethernet technologies with an innovative algorithmic design based on the DotStar compilation tool. The resulting system can provide low latency, high bandwidth and the flexibility of commodity components in a single framework, with an end-to-end latency of less then four microseconds and an OPRA feed processing rate of almost 3 million messages per second per core, with a packet payload of only 256 bytes.
An ergonomic study of visual optimization by light color managements (2014)

Abstract Light‐emitting diodes (LEDs) have the advantage of controllable light colors and provide the optimal lighting quality against various color attributes required in different environments. However, from the humanized design point of view, beside satisfying physical demands of people, it is also important to achieve satisfaction. With a good match between the LED lighting equipment and ambient colors, the space imagery that complies with psychological needs of human beings can be found. This is expected to become a new market direction for future lighting. In this study, the LED light source feature of adjustable correlated color temperature is used to match wall colors of typical commercial spaces and for the investigation and analysis of the impact of colors of light sources and environments on human beings. The measures of mental and subjective feelings of a group of people under various circumstances have also been investigated. Multivariate analysis of variance has been conducted on three color temperatures of light sources, six wall colors, and measures of five emotion adjectives, and the correlation between these three variables has been further investigated. © 2014 Wiley Periodicals, Inc. Col Res Appl, 41, 72–84, 2016
Large-Scale Simultaneous Hypothesis Testing (2004)

Current scientific techniques in genomics and image processing routinely produce hypothesis testing problems with hundreds or thousands of cases to consider simultaneously. This poses new difficulties for the statistician, but also opens new opportunities. In particular, it allows empirical estimation of an appropriate null hypothesis. The empirical null may be considerably more dispersed than the usual theoretical null distribution that would be used for any one case considered separately. An empirical Bayes analysis plan for this situation is developed, using a local version of the false discovery rate to examine the inference issues. Two genomics problems are used as examples to show the importance of correctly choosing the null hypothesis.
Data Exploration Toolkitfor serial diffraction experiments (2015)

Ultrafast diffraction at X-ray free-electron lasers (XFELs) has the potential to yield new insights into important biological systems that produce radiation-sensitive crystals. An unavoidable feature of the `diffraction before destruction' nature of these experiments is that images are obtained from many distinct crystals and/or different regions of the same crystal. Combined with other sources of XFEL shot-to-shot variation, this introduces significant heterogeneity into the diffraction data, complicating processing and interpretation. To enable researchers to get the most from their collected data, a toolkit is presented that provides insights into the quality of, and the variation present in, serial crystallography data sets. These tools operate on the unmerged, partial intensity integration results from many individual crystals, and can be used on two levels: firstly to guide the experimental strategy during data collection, and secondly to help users make informed choices during data processing.
Federated Multi-source Domain Adaptive Object Detection with Probabilistic Teacher (2023)

In order to reduce data collecting effort as well as increase data diversity in advanced surveillance systems, collaboration among multiple cameras is practical and efficient. However, training a CNN model at a centralized server may violate user privacy and data confidentiality. We propose a novel scenario wherein data providers (clients) can collaboratively train a model without revealing their datasets and map our problem to multi-source domain adaptive object detection under the federated setting. A Mutual Learning Teacher-Student Framework is setup on clients for domain adaptation. To reduce the false pseudo labels, the technique of Probability Teacher is adopted with the weak-strong augmentation for source/target data. Furthermore, the server fuses models from different clients by model aggregation algorithms, so as to generate a global model for the target domain. Experiments on real world dataset show that our approach outperforms other privacy preserving model aggregation methods.
Catalysis in Pickering emulsions (2020)

Particle-stabilised or Pickering emulsions are versatile systems. In the past 10 years a new application has emerged in the field of catalysis to use them as vehicles to carry out catalytic reactions, allowing a more environmentally friendly process with high conversions and selectivities and important advantages for catalyst recovery. As the area has advanced rapidly, the intention of this review is to summarize the latest innovations being reported. An overview is given regarding the kinds of liquid phases comprising the emulsion system, the different types of solid particle stabilizers (whether they contain catalyst or not) and the catalytic reactions studied. A section describing methods for recovering the catalyst is also included, in which various stimuli are discussed. Finally, the importance of using Pickering emulsions to carry out reactions in flow and in multi-step cascade systems is highlighted with various examples to support the benefits of transferring this technology to industrial processes.
I-FABP is decreased in COVID-19 patients, independently of the prognosis (2021)

In this pilot study, we observed a low I-FABP concentration in COVID-19 patients either with or without gastrointestinal symptoms, of which the pathophysiological mechanisms and clinical impact remain to be established. Further explorations on a larger cohort of patients will be needed to unravel the molecular mechanism of such observation, including the effects of malabsorption and/or abnormal lipid metabolism.
Non-toxic engineered carbon nanodiamond concentrations induce oxidative/nitrosative stress, imbalance of energy metabolism, and mitochondrial dysfunction in microglial and alveolar basal epithelial cells (2018)

Engineered nanoparticles are finding a wide spectrum of biomedical applications, including drug delivery and capacity to trigger cytotoxic phenomena, potentially useful against tumor cells. The full understanding of their biosafety and interactions with cell processes is mandatory. Using microglial (BV-2) and alveolar basal epithelial (A549) cells, in this study we determined the effects of engineered carbon nanodiamonds (ECNs) on cell viability, nitric oxide (NO) and reactive oxygen species (ROS) production, as well as on energy metabolism. Particularly, we initially measured decrease in cell viability as a function of increasing ECNs doses, finding similar cytotoxic ECN effects in the two cell lines. Subsequently, using apparently non-cytotoxic ECN concentrations (2 µg/mL causing decrease in cell number < 5%) we determined NO and ROS production, and measured the concentrations of compounds related to energy metabolism, mitochondrial functions, oxido-reductive reactions, and antioxidant defences. We found that in both cell lines non-cytotoxic ECN concentrations increased NO and ROS production with sustained oxidative/nitrosative stress, and caused energy metabolism imbalance (decrease in high energy phosphates and nicotinic coenzymes) and mitochondrial malfunctioning (decrease in ATP/ADP ratio).These results underline the importance to deeply investigate the molecular and biochemical changes occurring upon the interaction of ECNs (and nanoparticles in general) with living cells, even at apparently non-toxic concentration. Since the use of ECNs in biomedical field is attracting increasing attention the complete evaluation of their biosafety, toxicity and/or possible side effects both in vitro and in vivo is mandatory before these highly promising tools might find the correct application.
Mangomics: Information Systems Supporting Advanced Mango Breeding (2015)

RNA interference (RNAi) was first reported by Andrew Fire and Craig Mello in Caenorhabditis elegans (Fire et al., 1998). For this discovery, they were bestowed with the Nobel Prize in Physiology or Medicine for the year 2006 (Pushparaj et al., 2008). RNAi exists in plants as a defense strategy against viruses or uncontrolled transposon recruitment (Bernstein et al., 2001). It was observed that dsRNAs can cause specific knockdown of homologous mRNAs (Ahlquist et al., 2002; Schiffelers et al., 2004). Later, it was experimentally documented that small RNAs (21-to 25-nucleotides) were indeed essential for RNAi called as small interfering RNAs (siRNAs) (Bernstein et al., 2001). Moreover, RNAi phenomenon was also recorded in flies (Kennerdell et al., 2000; Ahlquist et al., 2002), and vertebrates (Kennerdell et al., 2000; Li et al., 2000). In this chapter, we discuss the RNAi phenomenon in the past, present, and future in therapeutics.
An NKX-COUP-TFII morphogenetic code directs mucosal endothelial addressin expression (2022)

Immunoglobulin family and carbohydrate vascular addressins encoded by Madcam1 and St6gal1 control lymphocyte homing into intestinal tissues, regulating immunity and inflammation. The addressins are developmentally programmed to decorate endothelial cells lining gut post-capillary and high endothelial venules (HEV), providing a prototypical example of organ- and segment-specific endothelial specialization. We identify conserved NKX-COUP-TFII composite elements (NCCE) in regulatory regions of Madcam1 and St6gal1 that bind intestinal homeodomain protein NKX2-3 cooperatively with venous nuclear receptor COUP-TFII to activate transcription. The Madcam1 element also integrates repressive signals from arterial/capillary Notch effectors. Pan-endothelial COUP-TFII overexpression induces ectopic addressin expression in NKX2-3<sup>+</sup> capillaries, while NKX2-3 deficiency abrogates expression by HEV. Phylogenetically conserved NCCE are enriched in genes involved in neuron migration and morphogenesis of the heart, kidney, pancreas and other organs. Our results define an NKX-COUP-TFII morphogenetic code that targets expression of mucosal vascular addressins.
Detoxification of the Photocurable Polymer by Heat Treatment for Microstereolithography (2013)

Microsterolithograpy is one of a well known process in three dimensional rapid prototyping fields. The micro stereolithography had many advantages compared with other three dimensional fabrication methods, but until now an objects fabricated by microstereolithography could not be applied to biomedical or biological fields because the material of the micro stereolithography, that was photo curable polymer, had no biocompatibility despite wide needs for those fields.In this report, stereographic objects with both cytocompatibility and transparency was realized by high temperature heat process in nitrogen atmosphere. Precise high temperature heat process parameter was checked by MTT assay which could quantify cell activity. Investigating aqueous solution of generated gas from photo curable polymer and eluted material from photo curable polymer revealed both absorbance spectra had same peaks around 245 nm. This results indicated reducing cytotoxic was due to sublimation and diffusion from cured photo curable polymer.This new heat process for microstereolithographic objects should be basic fabrication techniques for future development of biomedical micromachines, tissue engineering devices and portable health care devices.
of Variable Geometry Turbocharged Diesel Engines for Reduced Emissions (1998)

scheme is designed to minimize les (NOz) and generation of smoke 3ed with a variable geometry tur- external exhaust gas recirculation ,ate optimization results in operat- nissions and smoke generation are re joint management by VGT and
Additional file 1: of Subchronic exposure to titanium dioxide nanoparticles modifies cardiac structure and performance in spontaneously hypertensive rats (2019)

Figure S1. Spontaneous arrhythmic events. Different examples of arrhythmic events. Both, supraventricular (Supraventricular Extrasystole and Sinus Arrhythmia, SVA; Sinus Pause, SP) and ventricular (Atrio-ventricular block, AV block; Ventricular Extrasystole, VE) events were recorded. (PDF 324 kb)
A non-parametric approach for the estimation of intensity-frequency dependent noise (2014)

We present a non-parametric method estimating an intensity and frequency dependent noise from a single image. The noise model is estimated on image patches and can be used consequently in all patch-based denoising methods. The method applies to cases where no access is granted to the image noise model, in particular to scanned photographs and JPEG images. The general noise model and the method to evaluate it are validated by comparing the estimations with the corresponding ground-truth curves for raw and JPEG images. Denoising experiments on scanned photographs also support the efficiency of the estimation method.
Antidiabetic and Antioxidative Potential of Cystoseira myric a (2014)

Alloxan administration in male albino rats, induced diabetes by increasing blood glucose concentration and reducing hepatic glycogen content as compared to normal control group. Besides, serum lipid profile parameters such as total-cholesterol, triglyceride and low-density lipoprotein were also elevated, whereas, the level of high-density lipoprotein-cholesterol was reduced significantly (P<0.05) in diabetic rats. Treatment of diabetic animals with hot aquous extract of Cystoseiramyrica for 30 days, significantly lowered blood glucose level, elevated hepatic glycogen content and maintained body weight and lipid-profile parameters towards near normal range. Declined activity of antioxidant enzymes and concentration of non-enzymatic antioxidants were also normalized by drug treatment, thereby reducing the oxidative damage in the tissues of diabetic animals and hence indicating the anti-diabetic and antioxidant efficacy of the extract. Biochemical observations were further substantiated with histological examination of pancreas and liver.