gebhart/patrepeval huggingface dataset:
Development of Bismuth-Based High-Tc Superconducting Wires (2004)

(Bi, Pb)2Sr2Ca2Cu3OX (Bi2223) superconducting wires (Tc∼110 K) is a promising candidate of high-Tc superconducting wire which can be expected for practical use. We have proceeded with its research of Ag-sheathed wire using Bi2223 superconductor and has developed semi-mass producing long wires (in the kilometer class) with high Jc. And for application, magnet, power transformer and power cable have been developed. At present we improve the performance of Bi2223 wires and have proceeded with cable project in the real scale.But it is still necessary for practical use to improve the performance of Bi2223 wires. In this paper, we concentrated on the sintering process and applied controlled over pressure sintering method. The sintering process has a problem which the mass density increased on rolling process decreases during sintering. Since decreased density causes the formation of pores and a decrease of supercurrent between Bi2223 grains which grow during sintering, it is considered to be one of the major causes of the performance of Bi2223 wires. Controlled over pressure sintering is a method which applies gas pressure to Bi2223 wires during sintering because of suppression of decreasing mass density.As the results of short samples, controlled over pressure sintering method improved Bi2223 phase homogeneity, misalignment angle, connectivity, critical current density and mechanical property. Furthermore, when cooled in liquid nitrogen and warmed up to room temperature, the wires may often balloon up by vaporization of liquid nitrogen entered in the pores of filaments through the defects of the sheath. However controlled over pressure sintering removes pores in filaments and it is confirmed that wires were not ballooned after cooled in liquid nitrogen under 1 MPa for 24H so far.To apply controlled over pressure sintering to long length Bi2223 wires, we developed the large furnace which kilometer-scaled Bi2223 wires can be sintered. The performance of long length wires is almost equal to that of short samples.
Strategy to Enhance Dendritic Cell‐Mediated DNA Vaccination in the Lung (2020)

Abstract Here, a new paradigm is introduced to promote pulmonary DNA vaccination. Specifically, it is demonstrated that nanoparticles designed to rapidly penetrate airway mucus (mucus‐penetrating particle or MPP) enhance the delivery of an inhaled model DNA vaccine (i.e., ovalbumin‐expressing plasmids) to pulmonary dendritic cells (DC), leading to robust and durable local and trans‐mucosal immunity. In contrast, mucus‐impermeable particles are poorly taken up by pulmonary DC following inhalation, despite their superior ability to mediate DC uptake in vitro compared to MPP. In addition to the enhanced immunity achieved in mucosal surfaces, inhaled MPP unexpectedly provides significantly greater systemic immune responses compared to gold‐standard approaches applied in the clinic for systemic vaccination, including intradermal injection and intramuscular electroporation. It is also shown here that inhaled MPP significantly enhances the survival of an orthotopic mouse model of aggressive lung cancer compared to the gold‐standard approaches. Importantly, it is discovered that MPP‐mediated pulmonary DNA vaccination induces memory T‐cell immunity, particularly the ready‐to‐act effector memory‐biased phenotype, both locally and systemically. The findings here underscore the importance of breaching the airway mucus barrier to facilitate DNA vaccine uptake by pulmonary DC and thus to initiate full‐blown immune responses.
The plays (1988)

READERS whose interest in the Elizabethan drama is focused primarily on plays usually find Henslowe's diary a disappointment. The pedestrian prose, erratict spelling, chaotic organization, and (especially) the confusing figures seem as remote as it is possible to be from the passion and poetry of the Elizabethan drama. What, such readers wonder, do these endless lists and dry accounts have to do with the work of Shakespeare or Marlowe? While understandable, such an attitude ignores (or under-emphasizes) the fact that Elizabethan plays (like those of other ages) are rooted in the theatrical conditions of their time, and have developed as they have, at least in part, in response to those conditions. To understand Shakespeare and his contemporaries fully, therefore, we must try to imagine their works in their original theatrical context. As a guide to that context, Henslowe's diary is indispensable.
Fabrication of Super-hydrophobic Plastic Films via a Simple Method (2006)

The super-hydrophobic polymer thin films were prepared by industrial polymers by phase-separation method.The scanning electron microscopy(SEM) images of the surface morphology of the films showed that the surfaces exhibited nest-like and micro nano-structures.The surfaces showed super-hydrophobicity with a contact angle(CA) of 158.1°.The effects of different experimental conditions on the wettability of the films were discussed.The best fabricating conditions were:PMMA/PS(wt%) was 1/5~1/2,the treatment time by the selective solvent was more than 10 min and the temperature of the selective solvent was higher than 40℃.
Current Injection Logic Gate with Four Josephson Junctions (1980)

A novel current switching Josephson logic gate in which four junctions are connected in a loop is described. This four-junction logic gate can reduce an inductance included in the loop as small as possible, so that the higher switching speed and the smaller device size is expected. The switching threshold and the switching characteristics of the gate are investigated both theoretically and experimentally. Logic circuits based on the gates are also experimentally demonstrated.
Cytotoxicity of alpha -particle-emitting 5-\[211At]astato-2-deoxyuridine in human cancer cells (1997)

This study was performed to determine the cytotoxicity of alpha-particle-emitting 5-[211At]astato-2-deoxyuridine (i.e. [211At]AUdR) for monolayers of D-247 MG human glioma cells and SK-MEL-28 human melanoma cells. Cells in exponential growth were exposed to varying activity concentrations of [211At]AUdR and for comparison [211At]astatide and the Auger electron-emitting analogue, 5-[125I]iodo-2'-deoxyuridine (i.e. [125I]IUdR). Cell uptake, DNA binding and clonogenic survival as a function of activity concentration in the medium were determined following 2 and 20-h incubations. None of the survival curves had detectable shoulders, an observation consistent with high-LET effects. The A37 (initial activity concentration yielding 37% cell survival) were significantly lower for both cell lines following 20-h exposure of [211At]AUdR than [211At]astatide. After correcting for effects from non-cell-associated activity in the medium, the specific cytotoxicity of cell-associated and DNA-bound [211At]AUdR was estimated. In the 20-h incubation experiments, the A37 for DNA-associated [211At]AUdR corresponded to about one 211At atom bound per cell for both cell lines. Unlike [211At]AUdR, there was a biphasic survival response to [125I]IUdR, consistent with the lower fractional uptake of [125I]IUdR at higher activity concentrations. These studies suggest that [211At]AUdR warrants further evaluation as an endoradiotherapeutic agent for the treatment of rapidly proliferating cancers.
Experimental Study for the Determination of the Turbulence Onset in Natural Convection on Inclined Plates (2010)

In June, 8th, 2009 the balloon-borne solar telescope SUNRISE was launched from the Swedish Space Corporation balloon facility Esrange. A telescope with a mirror of 1 m in diameter ob-served the Sun during six days until the mission was terminated in Canada. The design process of SUNRISE and of any optical telescope requires the analysis of the effect of surrounding air on the quality of images. The turbulence encountered in the local telescope environment de-grades its optical performance. This phenomenon called `seeing' consists of optical aberrations produced by density non-homogeneities in the air along the optical path. The refraction index of air changes due to thermal non-uniformities so that the wavefront incident on the mirror is randomly distorted, and therefore, images are altered. When telescope mirrors are heated, as it happens in solar telescopes, and therefore they are at a temperature different from the environment's, natural convection occurs. It is then crucial to know whether the flow in front of the mirror is laminar or turbulent. After reviewing the literature, it was found that the scattering of results about the onset of the transition gives only rough orders of magnitude of the values of the critical Grashof numbers. Aiming to obtain more information about it, the problem of determination of the turbulence onset in natural convection on heated inclined plates in air environment was experimentally revisited. The transition has been determined from hot wire velocity measurements. The onset of turbulence has been considered to take place where velocity perturbations start to grow. Experiments have shown that the onset depends not only on the Grashof number, but also on other parameters as the temperature difference between the heated plate and the surrounding air. A correlation between dimensionless Grashof and Reynolds numbers has been obtained, fitting extraordinarily well the experimental data. The results are obtained in terms of non-dimensional numbers, this way they apply to any air pressure and therefore to any floating altitude
Prognostic Nomogram for Renal Insufficiency After Radical or Partial Nephrectomy (2006)

A nomogram was developed that can predict the 7-year probability of renal insufficiency in patients undergoing radical or partial nephrectomy.
Supplementary Fig. S5 from The PARP1 Inhibitor AZD5305 Impairs Ovarian Adenocarcinoma Progression and Visceral Metastases in Patient-derived Xenografts Alone and in Combination with Carboplatin (2023)

&lt;p&gt;Fig. S5 shows the effect of AZD5305 on the OC-PDX HOC22&lt;/p&gt;
Service‐Oriented Computing (2004)

Traditional approaches to software development - the ones embodied in CASE tools and modeling frameworks - are appropriate for building individual software components, but they are not designed to face the challenges of open environments. Service-oriented computing provides a way to create a new architecture that reflects components' trends toward autonomy and heterogeneity. We thus emphasize SOC concepts instead of how to deploy Web services in accord with current standards. To begin the series, we describe the key concepts and abstractions of SOC and the elements of a corresponding engineering methodology.
Development and characterization of micromachined hollow cathode plasma display devices (2002)

In this paper, we report the development of hollow cathode micro plasma devices made using micromachining techniques. Compared with larger discharge devices, micromachined discharge devices operate at much higher pressures, up to 1 atm. Linear current-voltage relationships are obtained, potentially simplifying the control electronics for such devices. The size of micromachined discharge units is reduced and the distribution of sizes and light intensity in an array is more uniform relative to previous devices.
Long-term follow-up of patients with locally advanced or metastatic thymic malignancies: The Eastern Cooperative Oncology Group (ECOG) experience (2004)

7050 Background: Chemotherapy is active and appears to prolong survival in patients (pts) with advanced thymic cancer. However, limited data exists about the long-term outcomes after systemic therapy. Methods: To assess this, we reviewed records on 123 pts entered on five prospective ECOG phase II trials conducted from 1982 through 2003; these studies evaluated cisplatin as a single agent or as platinum-based combination chemotherapeutic regimens (i.e. cisplatin, doxorubicin, cyclophosphamide (PAC); cisplatin, ifosfamide, etoposide (VIP); carboplatin, paclitaxel). In 23 pts with Stage III disease, PAC was administered prior to definitive radiotherapy. All pts. had unresectable Stage III or IV, histologically proven thymoma (n=111) or thymic carcinoma (n=12) without previous systemic chemotherapy. Pretreatment characteristics included a median age of 50 yrs, M:F = 75:48, PS 0–1 = 83% and prior radiation therapy in 31%. Results: Overall, 46 (39%) pts. had an objective response (PR or CR), 46 had stable disease while the remainder had progression or were inevaluable for response. Combination regimens were associated with a higher objective response rate (p<0.0001) and improved overall survival (p=0.035) compared to single agent, cisplatin. Pts with thymic carcinoma were associated with a poorer response rate (p=0.047) and PFS (p=0.014) and a trend towards worse OS (p=0.064) than pts with thymoma. Conclusions: 1) Combination chemotherapy produces high response rates with some durable remissions observed in pts with thymoma. 2) Thymic carcinoma is associated with a worse therapeutic outcome than thymoma. 3) The majority of patients with unresectable thymic malignancies still progress and novel treatments are clearly needed. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Bristol-Myers Squibb Scientific Advisory Board
Drug-induced seizures (2004)

Drugs can cause seizures by a direct epileptogenic effect on administration or after withdrawal, by metabolic effects such as hypoglycaemia that cause secondary seizures and by interacting with antiepileptic drugs to reduce their efficacy. Important examples include tricyclic antidepressants (particularly at high doses), venlafaxine, bupropion and clozapine. Antiepileptic drugs can themselves provoke or aggravate seizures. Withdrawal from central nervous system depressants including alcohol, antiepileptic drugs and benzodiazepines is also a common cause of this important adverse drug reaction.
A readout system for high-speed CCD cameras based on Advanced Telecommunications Computing Architecture (2012)

This paper describes the performance of a scalable readout system for high-speed CCD sensors based on the Advanced Telecommunication Computing Architecture specification. The paper reports the readout system performance tested with a IMPixel Frame Store CCD sensor for soft X-ray applications at synchrotron light sources. This camera is capable of producing image data at over 400 MB/s which must be processed in real-time and stored to disk. The high-level hardware architecture, signal processing data flow, and network protocol optimization are also be presented.
Antibacterial properties of the Vietnamese cajeput oil and ocimum oil in combination with antibacterial agents. (1992)

Main antibacterially active agents obtained from plants-Cajeput essential oil--1,8 cineol, linalool, alpha-terpineol and terpinen-4-ol, for example from Melalleuce leucadendron (Myrtaceae) as well as essential oil from Ocimum gratissimum (Labiatae) were combined in tests in vitro with selected antibiotics. Above mentioned plant products were found to be effective medicaments for local application in modern medical practice. Combinations with antibiotics potentiated their therapeutical action. On the basis of tests in vitro the synergistic action of these two kinds of medicaments, i.e., preparations traditionally used for a few last decades--antibiotics--might be well applied for therapeutical needs.
A Multi-Cell Cascaded Power Amplifier (2006)

A multi-cell cascaded power amplifier with a high output voltage capability, wide load range and high bandwidth is presented in this paper. The cascaded power amplifier is formed by combining a low-voltage linear power amplifier in series with multiple inverter cells. Therefore the cascaded power amplifier combines the advantages of a linear power amplifier with the advantages of a switched mode power amplifier. A high output voltage and bandwidth of 20kHz is achievable using very simple modulation and feedback control design. The dc voltages for the inverter cells and linear power amplifier are provided by an isolated, bidirectional dc-dc resonant converter. The dimensioning and physical structure of a 1.2kW, plusmn400V cascaded amplifier is given, and shows that a compact, flat system design is possible. Finally, digital simulation results verify the theoretical analysis of the amplifier
Time‐dependency of angiotensin II mediated vasomotor dysfunction (2009)

Angiotensin II (AngII), the main effector of the renin‐angiotensin system, plays an essential role in the regulation of blood pressure and it has been implicated in the pathogenesis of cardiovascular diseases. While AngII is known to alter endothelial function, the time‐course of this response remains poorly understood. The aim of this study was to compare the effects of acute vs chronic angiotensin II treatment on endothelium‐dependent vasomotor function. Wire myography was used to assess vasomotor function of aortic rings obtained from C57BL/6J male mice. Aortic rings were incubated with angiotensin II for either either 15 minutes or 4 hours. In another group, aortic rings were isolated from WT mice subjected to chronic AngII infusion (Alzet pump) at a rate of 2000 ng/kg/min for 14 days. Endothelium‐dependent vasomotor function was assessed by monitoring acetylcholine‐induced vasorelaxation. While AngII exposure for 15 min did not alter endothelium‐dependent vasomotor function, 4 h incubation with AngII significantly (~50%) impaired endothelium dependent vasodilation, compared to untreated rings. A similar level of vasomotor impairment was noted in aortic rings from mice subjected to chronic AngII infusion. These findings reveal a time‐dependency of AngII mediated vasomotor dysfunction and indicates that this response occurs via a mechanism that likely involves new protein synthesis. (HL26441)
Synthesis of Aceogenin Analogs as Potential Therapeutics for Treating Prostate Cancer (2003)

Abstract : New synthetic routes for preparing both the bis-THF and butenolide protions of the targeted acetogenin analogs have been established that avoid the pitfalls of previous strategies. These routes provide practical solutions to the problems associated with securing late-stage advanced intermediates in guantities sufficient for analog preparation. Current research efforts are focusing on optimizing the final aceogenin assembly. A brief investigation into alternative ways to connect the bis-THF with the butenolide led to development of a new Horner-Wadsworth-Emmons type coupling reaction between alkenes and aldehydes that involves rhodium catalyzed olefin hydrophosphorylation and a novel phosphonate elimination as key steps.
Symbolic Analyzer for Large Lumped and Distributed Networks (2007)

A symbolic linear analyzer that integrates the analysis of both lumped and distributed networks is presented in this paper. This is achieved by implementing a consistent set of notations and a unified mathematical framework. The merits of sparse symbolic matrices are utilized to develop a complete symbolic sparse toolbox that includes all basic elements of electrical circuits. A new storage scheme called Row-Indexed Semi-Symetric (RISS) sparse is proposed and implemented for symbolic network matrices. Several existing and newly developed matrix solvers are implemented and their performances are compared. These solvers are used in the proposed symbolic solver to provide a multi-path analysis root that can be optimized for a particular problem. The overall performance of the proposed symbolic analyzer is assessed practically using several application examples. The obtained results are found in agreement with the results obtained from previously reported analyses and thus confirm validity of the adopted formula approximation method. A polynomial fitting shows that the time complexity of a variable size RC network is super-quadratic with the number of network sections. A substantial reduction in the analysis time of a large ladder RC network is demonstrated with the implementation of macromodeling techniques.
TiO2-coated single and multi-wavelength shifted Bragg grating in SOI platform as add-drop filter (Conference Presentation) (2017)

We present a sidewall patterned shifted Bragg grating based on an add-drop filter in silicon-on-insulator platform with a coating of amorphous titanium dioxide. This particular waveguide grating is equivalent to two identical gratings written across either sides of a waveguide with a longitudinal offset of half of a period. The add-drop operation occurs on the basis of mode conversion due to shifted sidewall structure followed by mode splitting with asymmetric Y-junction. A signal launched through the wide arm (single mode) of an asymmetric Y-junction generates the fundamental mode at the stem of the Y-branch. First order mode is generated at the stem if the signal is launched through the narrow arm. Thus, an asymmetric Y-branch is used as a mode splitter fulfilling proper limiting condition for an adiabatic operation. A signal at the Bragg wavelength launched through the wide arm of asymmetric Y-junction generates fundamental mode at the stem. The fundamental mode converted to first order upon reflection from the shifted Bragg grating. The reflected mode couples into the narrow arm of the Y-junction. The bandwidth of the reflected signal depends on the grating strength. We used 80 nm grating amplitude for 800 nm wide waveguide. The height of the guiding layer is 220 nm. The TiO2 thickness is set to 180 nm. A reflection bandwidth of 2.2 nm with 14 dB extinction ratio is obtained at 1552.5 nm for 300 µm long grating. We further demonstrate the potential of TiO2 recoating with atomic layer deposition as a method of fine tuning the spectrum.
The Flatland Boundary Layer Experiments (1998)

This article describes the 1995 and 1996 Flatland boundary layer experiments, known as Flatland95 and Flatland96. A number of scientific and instrumental objectives were organized around the central theme of characterization of the convective boundary layer, especially the boundary layer top and entrainment zone. In this article the authors describe the objectives and physical setting of the experiments, which took place in the area near the Flatland Atmospheric Observatory, near Champaign–Urbana, Illinois, in August–September 1995 and June–August 1996. The site is interesting because it is extremely flat, has uniform land use, and is in a prime agricultural area. The instruments used and their performance are also discussed. The primary instruments were a triangle of UHF wind-profiling radars. Rawinsondes and surface meteorological and flux instruments were also included. Finally, some early results in terms of statistics and several case studies are presented.
Accurate camera calibration using iterative refinement of control points (2009)

We describe a novel camera calibration algorithm for square, circle, and ring planar calibration patterns. An iterative refinement approach is proposed that utilizes the parameters obtained from traditional calibration algorithms as initialization to perform undistortion and unprojection of calibration images to a canonical fronto-parallel plane. This canonical plane is then used to localize the calibration pattern control points and recompute the camera parameters in an iterative refinement until convergence. Undistorting and unprojecting the calibration pattern to the canonical plane increases the accuracy of control point localization and consequently of camera calibration. We have conducted an extensive set of experiments with real and synthetic images for the square, circle and ring pattern, and the pixel reprojection errors obtained by our method are about 50% lower than those of the OpenCV Camera Calibration Toolbox. Increased accuracy of camera calibration directly leads to improvements in other applications; we demonstrate recovery of fine object structure for visual hull reconstruction, and recovery of precise epipolar geometry for stereo camera calibration.