gebhart/patrepeval huggingface dataset:
Alternative Roles for Metal Ions in Enzyme Catalysis and the Implications for Ribozyme Chemistry (2006)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAlternative Roles for Metal Ions in Enzyme Catalysis and the Implications for Ribozyme ChemistryRoland K. O. Sigel and Anna Marie PyleView Author Information Institute of Inorganic Chemistry, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland and Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University, 266 Whitney Avenue, New Haven, Connecticut 06520 Cite this: Chem. Rev. 2007, 107, 1, 97–113Publication Date (Web):December 19, 2006Publication History Received27 February 2006Published online19 December 2006Published inissue 1 January 2007https://doi.org/10.1021/cr0502605Copyright © 2007 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views3095Altmetric-Citations250LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (1 MB) Get e-AlertscloseSUBJECTS:Catalysis,Genetics,Ions,Metals,Peptides and proteins Get e-Alerts
Entomological Origin Of Honey Discriminated By Nmr Chloroform Extracts In Ecuadorian Honey (2015)

Honeys are produced by Apis mellifera and stingless<br> bees (Meliponini) in Ecuador. We studied honey produced in<br> beeswax combs by Apis mellifera, and honey produced in pots by<br> Geotrigona and Scaptotrigona bees. Chloroform extracts of honey<br> were obtained for fast NMR spectra. The 1D spectra were acquired at<br> 298 K, with a 600 MHz NMR Bruker instrument, using a modified<br> double pulsed field gradient spin echoes (DPFGSE) sequence.<br> Signals of 1H NMR spectra were integrated and used as inputs for<br> PCA, PLS-DA analysis, and labelled sets of classes were successfully<br> identified, enhancing the separation between the three groups of<br> honey according to the entomological origin: A. mellifera,<br> Geotrigona and Scaptotrigona. This procedure is therefore<br> recommended for authenticity test of honey in Ecuador.
Repair of Bridge Girder Damaged by Impact Loads with Prestressed CFRP Sheets (2007)

A sound repair on a 40 year old four-span prestressed concrete girder bridge is performed with an innovative strengthening method using prestressed carbon fiber reinforced polymer (CFRP) sheets. In fact, this application is the first North American field application of its type. An adequate repair design is conducted based on the American Association of State Highway and Transportation Officials Load Resistance Factor Design (AASHTO LRFD) and the Canadian Highway Bridge Design Code. To ensure the feasibility of the site application using prestressed CFRP sheets, tests are conducted and closed-form solutions are developed to investigate the behavior of the anchor system that is necessary for prestressing the CFRP sheets. A full-scale finite-element analysis (FEA) is performed to investigate the flexural behavior of the bridge in the undamaged, damaged, and repaired states. The AASHTO LRFD exhibits conservative design properties as compared to the FEA results. The repaired bridge indicates that the flexural strength of the damaged girder has been fully recovered to the undamaged state, and the serviceability has also been improved. An assessment based on the AASHTO rating factor demonstrates the effectiveness of the repair.
Are Political Ties and Market Capabilities Complements or Substitutes in Fostering Firm Performance? Evidence from China (2016)

While the conventional wisdom advocates a complementary view between political ties and market capabilities, we challenge it by proposing that they function as substitutes in affecting firm performance. We argue that the simultaneous use of political ties and market capabilities yields strong tensions: Internally, the incompatibility of their focuses and routines produces a crowding- out effect; externally, government interference arising from political ties invites a grabbing-hand effect. Results based on publicly listed firms in China from 2001 to 2014 provide strong support to our propositions. Political ties and marketing/operations capabilities have a negative joint effect on a firm’s future financial performance. Moreover, this substitution effect is stronger when market institutional development is high and for private firms (versus state-owned enterprises).
Rice Big Grain 1 promotes cell division to enhance organ development, stress tolerance and grain yield (2020)

Grain/seed yield and plant stress tolerance are two major traits that determine the yield potential of many crops. In cereals, grain size is one of the key factors affecting grain yield. Here, we identify and characterize a newly discovered gene Rice Big Grain 1 (RBG1) that regulates grain and organ development, as well as abiotic stress tolerance. Ectopic expression of RBG1 leads to significant increases in the size of not only grains but also other major organs such as roots, shoots and panicles. Increased grain size is primarily due to elevated cell numbers rather than cell enlargement. RBG1 is preferentially expressed in meristematic and proliferating tissues. Ectopic expression of RBG1 promotes cell division, and RBG1 co-localizes with microtubules known to be involved in cell division, which may account for the increase in organ size. Ectopic expression of RBG1 also increases auxin accumulation and sensitivity, which facilitates root development, particularly crown roots. Moreover, overexpression of RBG1 up-regulated a large number of heat-shock proteins, leading to enhanced tolerance to heat, osmotic and salt stresses, as well as rapid recovery from water-deficit stress. Ectopic expression of RBG1 regulated by a specific constitutive promoter, GOS2, enhanced harvest index and grain yield in rice. Taken together, we have discovered that RBG1 regulates two distinct and important traits in rice, namely grain yield and stress tolerance, via its effects on cell division, auxin and stress protein induction.
Stereoselective synthesis of β,γ-unsaturated amino acids (1987)

Abstract
Panel Title: Reconfigurable Computing " Different Perspectives (2003)

With vanishing time to market windows and rapidly changing design specifications, flexibility becomes the number one constraint in the development of the SoC's of the future. Adding efficient power and resource management to the requirements list made the cry for reconfigurable computing even louder. In this panel we will listen to different industry and research representatives debating their approaches to reconfigurable computing.
EUV/X-ray Hartmann wavefront sensors and adaptive optics at Imagine Optic (Conference Presentation) (2019)

Since its creation in 1996, Imagine Optic designed and manufactured high performance Shack-Hartmann wavefront (WF) sensors for many kinds of applications such as telescope alignment, laser characterization, optics qualification or adaptive optics, and for many different fields such as space optics, microscopy, high power lasers or lithography. Since 2003, Imagine Optic is actively developing EUV to X-ray Hartmann WF sensors for applications on metrology beams emitted by synchrotrons, free-electron lasers, plasma-based soft X-ray lasers and high harmonic generation. Our most recent developments include the realization of a EUV sensor adapted to strongly convergent or divergent beams having numerical aperture as high as 0.15, as well as the production of a hard X-ray sensor working above 10 keV, providing outstanding repeatability as good as 4 pm rms. Our sensors have demonstrated their high usefulness for the metrology of EUV to X-ray optics from single flat or curved mirrors to more complex optical systems (Schwarzschild, Kirkpatrick-Baez static or based on bender technology or with activators). In terms of optics qualification is a clear advantage of actually measuring the wavefront at-wavelength. Also, we show active Kirkpatrick-Baez alignment in few minutes using our WF sensor in both manual and automatic loops at the benefit of strong improvement of the beam focalization on the sample. Recently we started developing our own compact deformable grazing incidence mirror bender. We present a review of the developed sensors, as well as experimental demonstrations of their benefits for optical metrology of various EUV and X-ray optics.
Mechanism of Formation of Particle Deposition Layers by an Aerosol Flow. (1996)

粒子層の形成機構を乱流域における沈着と再飛散の同時現象として検討した。微粉体 (フライアッシュ; 質量中位径3μm) を気中分散させ, エアロゾル流としてガラス管 (内径12.5mm) 内に導き, ビデオマイクロスコープによる観察および画像解析を行った結果, 以下のことが分かった.低湿度で保存した粉体を用いると, 筋状沈着層の他に膜状沈着層が形成されるが, 除電により膜状沈着層は抑制することができる.筋状沈着層は, 斑点状の凝集体が斜め後方に延びることにより成長する.また, 凝集体は定位置で成長するのではなく, 形状によらずほぼ一定速度で流れ方向にゆっくりと移動する.これは, 凝集体の前面では主に微小凝集粒子が再飛散し, 後部では新たに沈着層が形成される結果として生じる現象である. ここでは, エアロゾル粒子の衝突が再飛散に対して重要な役割を果たしている.移動速度は沈着フラックスを用いてほぼ説明できるが, 厳密には沈着・再飛散同時現象における凝集体への衝突フラックスと対応させるべきである.
HIV Infection and the Acquired Immunodeficiency Syndrome: A Strategy for Public Education (1987)

AIDS (acquired immunodeficiency syndrome) is a terrifying new illness with a tremendous psychological impact. A thorough public educational scheme is needed to defuse the unwarranted fear of casual infection while simultaneously instilling a proper respect for the HIV virus and its modes of transmission. The goal is both to reduce public fears and reduce spread of the epidemic. Non-infected individuals would hopefully develop or continue a lifestyle that keeps them disease free. Infected individuals would face less ostracism. A stepwise educational scheme has been devised and implemented at SHAPE, Belgium (Supreme Headquarters Allied Powers Europe).
Grazing-angle incidence hard X-ray nanoscope (2008)

Sessions 3
Colour Spread Transform Data Hiding Capacity Using Complex Wavelets (2007)

Publication in the conference proceedings of EUSIPCO, Poznan, Poland, 2007
Preschool vision screening using the MTI-Photoscreener. (2002)

Amblyopia is a condition that, if detected and treated early, can improve vision for most children. Thus, both pediatric and ophthalmologic groups have acknowledged the need for preschool vision screening. However, vision screening is the exception rather than the rule for preschoolers, since traditional methods of vision screening are often inappropriate for the preschool population and almost impossible for those children who are preverbal or nonverbal, developmentally delayed, and/or have chronic illnesses or disabilities. This study evaluated the use of a photoscreener to detect vision problems in a preschool population. Fifty-one children ages 3 to 5 years were evaluated using the MTI Photoscreener. Results were compared with a complete ophthalmologic examination, including cycloplegia. The sensitivity and specificity calculated for this study was 83% and 68%, respectively. Findings conclude that the MTI Photoscreener detected a broad range of vision problems, seemed to require less time, and seemed more acceptable to preschoolers when compared with the traditional vision screening methods performed by registered nurses. Although the sensitivity and specificity rates for this study were less than desired, it is likely that both could be improved with additional photo interpretation training.
709 Backflow Effect of Nematic Liquid Crystals Induced Magnetic Field : Effect of Tilt Angle (2001)

ti 〃 angie
Treatment of paediatric vancomycin intoxication: a case report and review of the literature (2010)

Division of Nephrology, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Canada, Division of Image-Guided Therapy, Earl Glenwood Coulson Chair, Medical Imaging, Department of Diagnostic Imaging, Hospital for Sick Children, University of Toronto, Toronto, Canada, Center for Clinical Investigation, Yale School of Medicine, New Haven, CT, USA and Howard Hughes Medical Institute, Yale School of Medicine, New Haven, CT, USA
Nematoda (Roundworms) (2006)

Abstract The Nematoda are a group of nonsegmented worm‐like invertebrates that occur worldwide in a wide range of habitats.
Novel Pd–Co Electrocatalyst Supported on Carbon Fibers with Enhanced Electrocatalytic Activity for Coal Electrolysis To Produce Hydrogen (2018)

Production of hydrogen from electrolysis of coal slurry is a new approach combining the clean utilization of coal with hydrogen production. A novel Pd–Co nanoelectrocatalyst supported on carbon fibers (PdCo/CFs) prepared by impregnation and reduction was developed and first applied to coal electrolysis for hydrogen generation. The performance of the PdCo/CFs electrocatalysts is superior to that of pure Pd/CFs catalyst with an improvement of about 16.9%. The improved performance can be attributed to modification of surface electronic structure due to alloying. The materials synthesized herein are promising anode catalysts for coal electrolysis to produce hydrogen.
Assessment methodology of counter-personnel high power electromagnetic millimeter wave effects (2013)

Utilizing the Citrobacter rodentium-induced transmissible murine colonic hyperplasia (TMCH) model, we measured hyperplasia and NF-κB activation during progression (days 6 and 12 post-infection) and regression (days 20-34 post-infection) phases of TMCH. NF-κB activity increased at progression in conjunction with bacterial attachment and translocation to the colonic crypts and decreased 40% by day 20. NF-κB activity at days 27 and 34, however, remained 2-3-fold higher than uninfected control. Expression of the downstream target gene CXCL-1/KC in the crypts correlated with NF-κB activation kinetics. Phosphorylation of cellular IκBα kinase (IKK)α/β (Ser(176/180)) was elevated during progression and regression of TMCH. Phosphorylation (Ser(32/36)) and degradation of IκBα, however, contributed to NF-κB activation only from days 6 to 20 but not at later time points. Phosphorylation of MEK1/2 (Ser(217/221)), ERK1/2 (Thr(202)/Tyr(204)), and p38 (Thr(180)/Tyr(182)) paralleled IKKα/β kinetics at days 6 and 12 without declining with regressing hyperplasia. siRNAs to MEK, ERK, and p38 significantly blocked NF-κB activity in vitro, whereas MEK1/2-inhibitor (PD98059) also blocked increases in MEK1/2, ERK1/2, and IKKα/β thereby inhibiting NF-κB activity in vivo. Cellular and nuclear levels of Ser(536)-phosphorylated (p65(536)) and Lys(310)-acetylated p65 subunit accompanied functional NF-κB activation during TMCH. RSK-1 phosphorylation at Thr(359)/Ser(363) in cellular/nuclear extracts and co-immunoprecipitation with cellular p65-NF-κB overlapped with p65(536) kinetics. Dietary pectin (6%) blocked NF-κB activity by blocking increases in p65 abundance and nuclear translocation thereby down-regulating CXCL-1/KC expression in the crypts. Thus, NF-κB activation persisted despite the lack of bacterial attachment to colonic mucosa beyond peak hyperplasia. The MEK/ERK/p38 pathway therefore seems to modulate sustained activation of NF-κB in colonic crypts in response to C. rodentium infection.
On the operational definition of fatty liver (2018)

We discuss the present operational definition of fatty liver and its shortcomings.
Potential Regulation for Surface-Enhanced Raman Scattering Detection and Identification of Carotenoids (2023)

Surface-enhanced Raman scattering (SERS) is often impaired by the limited affinity of molecules to plasmonic substrates. Here, we use carbon fiber microelectrodes modified with silver nanoparticles as a plasmonic microsubstrate with tunable affinity for enrichment and molecular identification by SERS. The silver nanoparticles self-assemble by electrostatic interaction with diamine molecules that are electrochemically grafted onto the surface of the microelectrodes. β-carotene and trans-β-Apo-8'-carotenal, producing similar resonant SERS spectra, are employed as model molecules to study the effect of electroenrichment and SERS screening for different electrode potentials. The data show that at a characteristic electrode potential, the low affinity of polyene chains without hydrophilic groups to the substrate can be overcome. Different potentials were applied to recognize the two types of carotenoids by their typical SERS signal, and the applicability of this strategy was further confirmed in the environment of a real cell culture. The results indicate that by regulating the potential, carotenoid molecules with a similar molecular structure can be selectively quantified and identified by SERS. The developed SERS-active microelectrode is expected to help the development of portable, miniaturized point-of-care diagnostic SERS sensors.
Uptake of γ‐Aminobutyric Acid and Glycine by Synaptosomes from Postmortem Human Brain (1986)

Synaptosomes prepared from frozen postmortem human brain accumulated the neurotransmitter gamma-aminobutyric acid (GABA) and the conformationally restricted GABA analogue cis-3-aminocyclohexanecarboxylic acid (ACHC) by a sodium-dependent, temperature-sensitive, high-affinity transport process into an osmotically sensitive compartment. This transport process could be inhibited by GABA analogues (ACHC, 2,4-diaminobutyric acid, nipecotic acid, arecaidine, guvacine) that have been shown in studies on other species to be relatively selective for neuronal rather than glial uptake systems, whereas the glial uptake inhibitor beta-alanine was ineffective. Synaptosomes prepared from frozen post-mortem human medulla and spinal cord, but not cerebral cortex, took up the neurotransmitter glycine by a sodium-dependent high-affinity transport process. The kinetic parameters for the high-affinity uptake of GABA, ACHC, and glycine were Km = 10 +/- 3, 49 +/- 19, and 35 +/- 19 microM; and Vmax = 98 +/- 15, 84 +/- 25, and 5.5 +/- 2.5 nmol/min/100 mg protein, respectively. These results demonstrate the feasibility of using human CNS preparations for studying GABA and glycine uptake, and suggest that such studies may be useful neurochemical markers for transmitter-specific presynaptic terminals in health and disease.
Introduction of a Carboxymethylamino(or oxy Or thio) Group in the 3 Position of 2-Aryl(or Arylmethyl)isoindol-1-ones from α Hydroxylactams (1997)

International audience
The landscape of epilepsy-related GATOR1 variants (2018)

Our data emphasize the increasingly important role of GATOR1 genes in the pathogenesis of focal epilepsies (>180 probands to date). The GATOR1 phenotypic spectrum ranges from sporadic early-onset epilepsies with cognitive impairment comorbidities to familial focal epilepsies, and SUDEP.
Postconditioning: Reduction of reperfusion-induced injury (2006)

Reperfusion has the potential to introduce additional injury that is not evident at the end of ischaemia per se, i.e. reperfusion injury. Reperfusion injury is expressed as endothelial and microvascular dysfunction, impaired blood flow, metabolic dysfunction, cellular necrosis, and apoptosis. There is an impressive array of mechanisms contributing to reperfusion injury. Postconditioning, defined as brief periods of reperfusion alternating with re-occlusion applied during the very early minutes of reperfusion, mechanically alters the hydrodynamics of early reperfusion. However, postconditioning also stimulates endogenous mechanisms that attenuate the multiple manifestations of reperfusion injury listed above. These mechanisms include ligands, such as adenosine and opioids, that act as proximal triggers to stimulate molecular pathways involving mediators such as protein kinase C, mitochondrial ATP-sensitive potassium channels, and survival kinases. Postconditioning may also inhibit deleterious pathways such as p38 and JNK mitogen-activated protein (MAP) kinases and attenuate the damage to endothelial cells and cardiomyocytes from oxidants, cytokines, proteases, and inflammatory cells. Postconditioning has been shown to inhibit the mitochondrial permeability transition pore. Hence, postconditioning marshals a variety of endogenous mechanisms that operate at numerous levels and target a broad range of pathological mechanisms. Two clinical studies in patients with acute myocardial infarction have demonstrated that postconditioning was effective in reducing infarct size. Postconditioning indirectly supports the concept of reperfusion injury in animal models of ischaemia-reperfusion and in patients, and exerts cardioprotection that is equivalent to that of ischaemic preconditioning.
Interface mixing of Al∕Fe and Fe∕Al bilayer systems and the role of Ti as a stabilizing interlayer using Rutherford backscattering spectrometry and x-ray reflectometry (2008)

Al ∕ Fe and Fe∕Al bilayer films with and without a Ti stabilizing interlayer at the interface have been grown on Si wafers using dc magnetron sputtering. X-ray reflectometry and Rutherford backscattering spectrometry were used to probe individual layer thicknesses and intermixing lengths. It is observed that the intermixing length is always higher when the Fe layer is on top of the Al layer. The samples with the Ti stabilizing layer, particularly when the Al layer is on top of the Fe, show that the Ti layer promotes the formation of abrupt interfaces.
Adaptive TCP Layer (2006)

This chapter contains sections titled: Introduction TCP Operation and Performance TCP for Mobile Cellular Networks Random Early Detection Gateways for Congestion Avoidance TCP for Mobile Ad Hoc Networks References
Characterization of Citrate Transport through the Plasma Membrane in a Carrot Mutant Cell Line with Enhanced Citrate Excretion (2003)

The superior ability of citrate excretion in a carrot (Daucus carota L.) mutant cell line, namely IPG (insoluble phosphate grower) [Takita et al. (1999a) Plant Cell Physiol. 40: 489] cells has been characterized in terms of citrate transport at the plasma membrane. IPG cells released about a 20-fold increase in citrate in comparison with malate, while the concentration of malate was only 35% lower than that of citrate in the cell sap. Citrate excretion was sensitive to anion channel blockers, such as niflumic acid and anthracene-9-carboxylic acid. These results indicate that IPG cells release citrate through the plasma membrane using citrate specific anion channels. The rate of citrate release from IPG cells was not affected by the concentration of aluminum (0 and 50 micro M), soluble P(i) (0 or 2 mM) and the pH (4.5-5.6) of the medium, suggesting that anion channels would not be regulated by such external conditions. Citrate excretion correlated with the H(+) efflux, possibly from the action of H(+)-ATPase on the plasma membrane. The activity of plasma membrane H(+)-ATPase was about three times higher in IPG cells than in wild-type cells, and might be involved in the high citrate excretion ability.
Digitale Podiumsdiskussion via ZOOM (2023)

The school years 20/21 and 21/22 were marked by the Corona pandemic, which meant a change in the organization of lessons (distance learning). In order to be able to work on a topic together with all students and to discuss it subsequently, the project “Panel Discussion” was developed at the Praxismittelschule of the Vienna University of Teacher Education. The goal was to discuss socio-political topics on a digitally organized podium and thus to initiate democracy learning across classes.