gebhart/patrepeval huggingface dataset:
Dynamics of a Q-switched Nd:YVO4/Cr:YAG laser under periodic modulation (2018)

In this work, we present the simulation results of a passively Q-switched Nd: YVO4/Cr:YAG laser model with pump modulation for applications in laser stabilization control contemplating different harmonic regimes. We study in detail the complex dynamics by varying the values of two control parameters: pump power and external frequency. By using bifurcation diagrams, state diagrams, and basins of attraction we demonstrated the coexistence of multiple attractors (multistability) and the phase locking dependent regimes of the control parameters. Our results can be used to improve the control of stability (minimizing the deviation of amplitudes in the pulses and the repetition rate) of a real Q-switched laser.
The amino terminus of the human C5a receptor is required for high affinity C5a binding and for receptor activation by C5a but not C5a analogs. (1994)

The binding domain of the human C5a receptor consists of two distinct and physically separable subsites. One of these sites binds the C-terminal 8 amino acids of C5a and is as yet undefined, while the second site lies in the N terminus of the receptor and interacts with the core of C5a. Two deletion mutants were prepared to probe the importance of this second site. Removal of residues 2-22 decreased the binding affinity for C5a by 600-fold, while extending the deletion through residue 30 caused a further 75-fold decrease. Thus, the N terminus is responsible for at least 45% of the total energy for the binding of C5a. The five aspartic acids present in the deleted segments appear to be critical residues, as their conversion to alanines accounts for most of the affinity lost in the two truncations. Despite its importance for binding, the N terminus is not necessary for signal transduction, as a C-terminal peptide analog of C5a was able to stimulate G protein activation and to generate a Ca2+ flux through a receptor lacking residues 2-22. However, intact C5a was a very poor activator of this truncated receptor. These results imply that interaction between the N terminus of the receptor and C5a produces a conformational change in C5a that allows it's C terminus to properly interact with and activate the receptor.
Endoillumination during vitrectomy and phototoxicity thresholds (2000)

Commercially available light sources for endoillumination during vitrectomy are not safe with respect to photochemical retinal damage. Even with maximal precautions macular phototoxic damage remains a factual danger during vitrectomy.
Inter-enterprise collaborative business process management (2002)

Conventional workflow systems are primarily designed for intra-enterprise process management, and they are hardly used to handle processes with tasks and data separated by enterprise boundaries, for reasons such as security, privacy, sharability, firewalls, etc. Further, the cooperation of multiple enterprises is often based on peer-to-peer interactions rather than centralized coordination. As a result, the conventional centralized process management architecture does not fit into the picture of inter-enterprise business-to-business e-commerce. We have developed a Collaborative Process Manager (CPM) to support decentralized, peer-to-peer process management for inter-enterprise collaboration at the business process level. A collaborative process is not handled by a centralized workflow engine, but by multiple CPMs, each representing a player in the business process. Each CPM is used to schedule, dispatch and control the tasks of the process that the player is responsible for, and the CPMs interoperate through an inter-CPM messaging protocol. We have implemented CPM and embedded it into a dynamic software agent architecture, E-Carry, that we developed at HP Labs, to elevate multi-agent cooperation from the conversation level to the process level for mediating e-commerce applications.
Asymmetric induction in a palladium-catalyzed TMM cycloaddition. Mechanistic implications regarding the reactive intermediate (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAsymmetric induction in a palladium-catalyzed TMM cycloaddition. Mechanistic implications regarding the reactive intermediateBarry M. Trost, Bingwei Yang, and Maria L. MillerCite this: J. Am. Chem. Soc. 1989, 111, 16, 6482–6484Publication Date (Print):August 1, 1989Publication History Published online1 May 2002Published inissue 1 August 1989https://pubs.acs.org/doi/10.1021/ja00198a102https://doi.org/10.1021/ja00198a102research-articleACS PublicationsRequest reuse permissionsArticle Views722Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Incidence of Sporadic and Familial Medullary Thyroid Carcinoma in Sweden 1959 Through 1981: A nationwide study in 126 patients (1990)

Medullary thyroid carcinoma (MTC) was identified in 276 patients (in 27 diagnosed at autopsy) by a review of virtually all 6,513 notifications of primary thyroid cancer ot the National Cancer Registry in Sweden 1959 through 1981. The diagnosis was confirmed in 268 of the 276 cases by histopathological and histochemical reexamination. Anamnestic data and morphological characteristics indicated that 208 (75%) patients had sporadic and 68 (25%) familial MTC. The mean ages at diagnosis of these two groups were 57.0 and 42.6 years respectively. The age-standardized incidence rate per 10(5) inhabitants was 0.18 for males and 0.23 for females. The age-specific incidence of sporadic MTC increased markedly with age, whereas no unequivocal rise was found after the age of 20 for familial disease. Standardized morbidity ratios (SMR), calculated separately for each of the six Swedish health care regions, revealed a roughly two-fold and mostly non-significant geographical variation in the occurrence of sporadic MTC. SMR for familial disease varied, however, between 0 and 306 and deviated highly significantly from the national average in four of the six regions. Regional differences in diagnostic intensity were considered unlikely as the sole explanation of this finding.
Model checking sequential software programs via mixed symbolic analysis (2009)

We present an efficient symbolic search algorithm for software model checking. Our algorithms perform word-level reasoning by using a combination of decision procedures in Boolean and integer and real domains, and use novel symbolic search strategies optimized specifically for sequential programs to improve scalability. Experiments on real-world C programs show that the new symbolic search algorithms can achieve several orders-of-magnitude improvements over existing methods based on bit-level (Boolean) reasoning.
Airway inflammation and bronchial microbial patterns in patients with stable chronic obstructive pulmonary disease (1999)

The effect of bacterial colonization of the bronchi on the progress of airflow limitation is not well known. Therefore, the pattern of airway inflammation in smokers and patients with stable chronic obstructive pulmonary disease (COPD) and its relation to bronchial microbial colonization was assessed. Eight nonsmoking and 18 smoking controls as well as 52 patients with COPD (28 mild, 11 moderate and 13 severe) were studied. All subjects were investigated by means of flexible bronchoscopy including protected specimen brush and bronchoalveolar lavage (BAL) sampling. Differential cell counts, cytokine (interleukin (IL)-1beta, IL-6, IL-8, IL-10 and tumour necrosis factor-alpha(TNF-alpha) concentrations and microbial patterns were determined in BAL fluid. Forced expiratory volume in one second (FEV1) % of the predicted value was inversely correlated with pack-yrs of cigarette smoking (r=-0.47, p<0.0001), the percentage of neutrophil (p=-0.56, p<0.0001) and IL-6 (p=-0.37, p=0.01) and IL-8 concentration (p=-0.43, p=0.004) in BAL fluid. Accordingly, pk-yrs of cigarette smoking (p=0.39, p=0.01) and IL-8 (p=0.69, p<0.0001) and TNFalpha (p=0.4, p<0.005) were positively correlated with the percentage of neutrophils in BAL fluid. Smoking controls and COPD patients were mainly colonized in the bronchial tree (33%) by community endogenous potentially pathogenic micro-organisms (PPMs). Colonization rates and patterns of PPMs were not affected by severity of airflow obstruction. The presence of PPMs was significantly associated with higher percentages of neutrophils (33.2+/-10.4% versus 10.1+/-3.5%, p=0.02) and TNF-alpha concentration (29.9+/-10.8 versus 6.3+/-2.1 pg x mL(-1), p=0.01) in BAL fluid. In conclusion, bronchial neutrophilia is a key inflammatory pattern in chronic obstructive pulmonary disease patients. Bronchial colonization with potentially pathogenic micro-organisms may represent an independent stimulus for additional airway inflammation.
A computational model for investigating the evolution of colonic crypts during Lynch syndrome carcinogenesis (2021)

Abstract Lynch syndrome (LS), the most common inherited colorectal cancer (CRC) syndrome, increases the cancer risk in affected individuals. LS is caused by pathogenic germline variants in one of the DNA mismatch repair (MMR) genes, complete inactivation of which causes numerous mutations in affected cells. As CRC is believed to originate in colonic crypts, understanding the intra‐crypt dynamics caused by mutational processes is essential for a complete picture of LS CRC and may have significant implications for cancer prevention. We propose a computational model describing the evolution of colonic crypts during LS carcinogenesis. Extending existing modeling approaches for the non‐Lynch scenario, we incorporated MMR deficiency and implemented recent experimental data demonstrating that somatic CTNNB1 mutations are common drivers of LS‐associated CRCs, if affecting both alleles of the gene. Further, we simulated the effect of different mutations on the entire crypt, distinguishing non‐transforming and transforming mutations. As an example, we analyzed the spread of mutations in the genes APC and CTNNB1 , which are frequently mutated in LS tumors, as well as of MMR deficiency itself. We quantified each mutation's potential for monoclonal conversion and investigated the influence of the cell location and of stem cell dynamics on mutation spread. The in silico experiments underline the importance of stem cell dynamics for the overall crypt evolution. Further, simulating different mutational processes is essential in LS since mutations without survival advantages (the MMR deficiency‐inducing second hit) play a key role. The effect of other mutations can be simulated with the proposed model. Our results provide first mathematical clues towards more effective surveillance protocols for LS carriers.
An integrated LP shaft generator for the More Electric aircraft (1998)

The engine power management and control architecture should enable power transfer to and from the airframe, and within the engine system, from the LP to the HP system. The paper considers some of the design aspects of the LP shaft generator and the selection of preferred generator technology (permanent magnet generator, switched reluctance generator, induction generator).
Acceleration of proteolysis during ripening of Cheddar-type cheese using of a streptokinase-producing strain of Lactococcus (2006)

Bovine milk contains a number of indigenous proteolytic enzymes, of which plasmin is the most important (Grufferty &amp; Fox, 1988; Bastian &amp; Brown, 1996; Kelly &amp; McSweeney, 2003). Plasmin (EC 3.4.21.7) is a serine proteinase with pH and temperature optima of 7·5 and 37 °C, respectively. In milk, most of the plasmin is present as its inactive precursor, plasminogen, which is converted to active plasmin by plasminogen activators (PA) present in milk, e.g., urokinase-type (u-PA) and tissue-type PA (t-PA) (Bastian &amp; Brown, 1996). Since plasmin, plasminogen and PA are associated with casein micelles, they are incorporated into cheese curd, while plasmin inhibitors and inhibitors of PA are lost with the whey. Plasmin incorporated in cheese curd acts on its substrate, the caseins, contributing significantly to primary proteolysis during ripening (Upadhyay et al. 2004b).
MWS 2009 Committees (2009)

Technical Program Committee: Afif Osseiran (Sweden) Anand Prasad (Japan) Antonio Cimm (Italy) Carlos Cordeiro (USA) Enrico Del Re (Italy) Fujio Watanabe (USA) Guillaume Vivier (France) Hsuan-Jung Su (Taiwan) Jeffrey Z. Tao (USA) Jia-Chin Lin (Taiwan) Jijun Luo (Germany) Jong-kae Fwu (USA) K.S. Natarajan (USA) Lie-Liang Yang (UK) M. Hamdi (HK) Mohinder Jankiraman (USA) Mohsen Guizani (USA) Mounir Hamdi (HK) Naftali Chayat (Israel) Nat Natarajan (USA) Neeli Prasad (Denmark) Pekka Ojanen (Finland) Pin-Han Ho (Canada) Pooi-Yuen Kam (Singapore) Roger S-K Cheng (HK) Shiao-Li Tsao (Taiwan) Shin Nomoto (Japan) Shinsuke Hara (Japan) Sumei Sun (Singapore) Tomoaki Ohtsuki (Japan) Uma S Jha (USA) Vijay K. Nair (USA) Vincent Lau (HK) Wei-Peng Chen (USA) Yih-Shen Chen (Taiwan) Yong Sun (UK) Yong-Hwan Lee (Korea) Youngkyu Choi (Korea) Zhifeng Tao (USA) Zhisheng Niu (China)
Restriction fragment length polymorphism typing of clinical isolates of Mycobacterium tuberculosis from patients with pulmonary tuberculosis in Madras, India, by use of direct-repeat probe (1995)

Large numbers of Mycobacterium tuberculosis isolates that were obtained from patients' sputa on diagnosis and during follow-up after short-course chemotherapy in Madras, India, have either no copy or only a single copy of IS6110. This poses a limitation for DNA fingerprinting with an IS6110-based probe to determine the frequency of exogenous reinfection versus that of endogenous reactivation. In the present study, we overcame this limitation by using an alternate probe, the direct-repeat element. Comparison of pre- and posttreatment isolates by direct-repeat restriction fragment length polymorphism analysis indicated a high degree of endogenous reactivation among patients who have relapses after the successful completion of chemotherapy.
Implementation of OpenWrt-based IP PnP gateway (2008)

Wireless Networks have been widely used by people with mobile device or laptop nowadays. There are more and more coffee shops, universities, hotels, and other business that provide services of accessing the Internet via wireless LAN. In the small-scale hotspot, like coffee shops and store, using common access gateway to provide service will be a good choice because of low cost and ease to construct.
Phase drift effects in optical CDMA (2002)

Fiber optic communication systems using CDMA have been proposed. While coherent detection is a reasonable assumption in many RF systems, semiconductor lasers for fiber applications have been shown to suffer from more serious phase variation that precludes fully coherent detection, the focus of previous CDMA research. The authors examine the effect of phase drift on several multiuser detectors for BPSK, as well as two detectors for BFSK. They show that when the desired user's phase can be tracked, BPSK match filtering offers better bit error rates than BFSK, and the authors derive closed form solutions for the error probabilities in the limit of infinitely long spreading codes modeled as a random sequence of plus and minus ones. When there is no phase tracking, they show that the probability of error of the multiuser detectors approaches one half.
Why MEM does not work in MR image reconstruction (1990)

This paper discusses the theory and application of the Maximum Entropy Method (MEM) to the reconstruction of Magnetic Resonance (MR) images. It is shown that the MEM is inappropriate for MR image reconstruction and that the usual heuristic justification is invalid in this case. The application of the MEM in MR image reconstruction is characterized as merely one of many constrained regularization approaches.
GENETICALLY ENGINEERED BACULOVIRUSES AS AGENTS FOR PEST CONTROL (1991)

INTRODUCTION . . . . . . . . ... . . . . .... . . . .... . . . . ... . . . . ..... . . .... ....... . . . .... . . . ... . . . . . 69 BACULOVIRUS BIOLOGY AND LIFE CyCLE . . . . . . . . . . . . . . . . . . . . . . . . . ... ...... . . . . . . .. .. . 70 Classification and General Properties 70 Infection and Replication in Insects 71 BACULOVIRUSES AS VIRAL INSECTICIDES .. . . . . . . : 74 FACTORS CONSTRAINING GREATER USE OF BACULOVIRUS PESTICIDES . . . 7S GENETICALLY ENHANCED VIRAL PESTICIDES . .... ..... ......... . . . . . .. .. . . . .. . . . . .. . . 76 ENGINEERING STRATEGIES .. .. . . . ... . . . . . .. . . . . . . ... . . . . .. . . . . . . .. ....... . . . . . . . . . . . . ... . . . . . . 78 ENVIRONMENTAL ISSUES .. . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ..... .. ... . . . . .... . . 80 FIELD-RELEASE TESTING . . . . .. . . .... . .. .. . . .. . . . . . ..... . . . .. . . . . . . . .. . . . . . . .. . . . . ... .. . ... . . ... 81 FUTURE: PROMISES AND PITFALLS.... . ..... . . . . . ....... . 84
Improving operative safety for cirrhotic liver resection (2001)

With improving perioperative assessment and operative techniques, most complications after cirrhotic liver resection can be treated with a low mortality rate. However, more care should be taken if prothrombin activity is low or there is a long operating time.
Subarachnoid Hemorrhage in Patients Aged 80 Years and Older: Single-Center Experience in 112 Consecutive Patients (2007)

With a globally aging population, it is imperative to develop specific treatment strategies for subarachnoid hemorrhage (SAH) in the elderly. However, the optimal management of SAH in the elderly remains controversial, especially for patients over 80 years of age. Therefore, we retrospectively evaluated the long-term outcomes measured in 112 consecutive patients aged over 80 years and treated at our single-institution. We conducted a retrospective review to evaluate the medical records and imaging studies of 112 patients treated with clipping or conservative therapy between January 1992 and August 2006. The neurological status was evaluated according to Hunt & Kosnik (H&K) Grade on admission, the “best” H&K grade during pre-surgical treatment, and Glasgow Outcome Scale (GOS) at discharge. Moreover, the long-term outcome was evaluated by administering a telephone questionnaire to the patients or relatives on October 2006. Ages of the 112 patients in our study ranged from 80 to 94 (average 84.0 yrs); 20 were men. Thirty-two patients underwent clipping procedures, and 80 patients were under conservative therapy. Overall results evaluated as GOS at discharge were: good recovery (GR), 21 (18.8%); moderate disability (MD), 10 (8.9%); severe disability (SD), 9 (8.0%); vegetative state (V), 4 (3.6%); and death (D), 68 (60.7%). This outcome was in accordance with the “best” H&K grade during pre-surgical treatment, not with H&K grade on admission. The outcome of the “best” H&K Grade 1 and 2 groups was significantly better than that of the “best” H&K Grade 3, 4 and 5 groups. Twenty of 28 patients waiting for chronic operation died due to re-rupture, vasospasm, and pneumonia before the operation. The overall outcome of patients with acute operation (GR12, MD4, SD5, V1 and D2) was significantly better than that of patients waiting for chronic operation (GR4, MD3, SD1, V0 and D20). Long-term follow-up showed the median survival periods after discharge of patients surviving in MD, SD, and V were 10 months, 4 months, and 2 months, respectively. Especially in the case of extremely aged patients, the long-term survival was rare even in MD condition. The leading cause of MD condition at discharge was the induction of dementia by long-term lying in bed. The “best” H&K Grade during pre-surgical treatment, not that on admission is a useful and practical tool for the selection of elderly patients affected by SAH as surgical candidates. Many patients planned for chronic operation could not survive until the operation period because of deterioration of general condition. Therefore, acute operation was recommended if the patient's “best” H&K Grade comes up to 1 or 2. All grades of GOS other than GR are a bad prognostic factor for survival after discharge. To prevent the induction of dementia and to achieve good functional condition, rehabilitation soon after surgery should be considered.
Inequitable poverty exposures in a clinical trial cohort of children with acute lymphoblastic leukemia: an opportunity to address racial and ethnic disparities in pediatric oncology (2023)

Black and Hispanic children with leukemia experience inferior survival compared to non-Hispanic White (NHW) children. Identifying modifiable social determinants of health can inform intervention targets to address inequities. We characterized the frequency of income poverty and household material hardship (HMH) by race/ethnicity in a clinical trial cohort with de novo acute lymphoblastic leukemia. Compared to NHW families, Black and Hispanic families reported more frequent HMH (19% vs. 47% vs. 68% respectively); low-income (27% vs. 52% vs. 74%), and combined low-income and HMH (12% vs. 37% vs. 52%) poverty exposures. Disparate poverty exposures are interventional targets to address racial/ethnic outcome inequities.
Enantioselective Total Synthesis of (+)-Leucascandrolide A Macrolactone (2003)

[reaction: see text] The enantioselective synthesis of the (+)-leucascandrolide A macrolactone has been achieved in 20 linear steps from 1,3-propanediol. The key steps in the synthesis are a reductive cleavage of bicyclic ketal 5 to establish the C15 stereogenic center and a diastereoselective aldol of the boron enolate of methyl ketone 3 to aldehyde 4 in preparation for a heteroconjugate addition for the introduction of the C3 stereocenter.
Enzyme selectivity as a tool in analytical chemistry (2007)

The addition of testosterone does not appear to influence mammographic breast density in women concurrently treated with a common oral estrogen/progestogen regimen for a period of 6 months.