gebhart/patrepeval huggingface dataset:
High-frame-rate retrospective imaging of mouse-embryo cardiac function using annular array and Doppler-derived gating (2013)

A high-frequency (HF) imaging system based on a custom 5-element, 40 MHz annular array has been used to study the cardiovascular development of mouse embryos. High-frame-rate imaging of the heart dynamics was achieved using a retrospective reconstruction method based on Doppler-derived electrocardiogram (ECG) waveforms and respiratory gating was used to suppress motion artifacts. The ECG signals were obtained by measuring blood-flow velocities in major arteries of in-vivo mouse embryos using a custom HF Doppler apparatus made from two 20 MHz, single-element, PZT transducers with a Doppler sample volume of 15 mm. Co-registered M-mode data were acquired from the annular array excited with a 5-channel pulser/receiver. A synthetic-focusing (SF) algorithm was used to improve spatial resolution (&amp;lt;100 µm), depth-of-field (&amp;gt;10 mm) and signal-to-noise ratio (&amp;gt;45 dB). This technique was used on embryos aged from 11.5 to 14.5 days and provided high-resolution, morphologically correct B-mode cine-loops of the heart chamber dynamics at frame rates of 1 kHz. The ultra-fine temporal resolution (1 ms) allowed for precise quantification of the mean cardiac cycle length and detailed visualization of fast events such as opening and closing of the mitral valve. The speckle characteristics of the high-resolution images could be used to assess blood flow and to quantify myocardial strain at each developmental stage of the embryonic heart.
ChemInform Abstract: Synthesis, Crystal Structure, and Magnetic Properties of RbV2SeO7 as Compared with KV2SeO7. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Gene x environment interactions impact endometrial function and the menstrual cycle: PROGINS, life history, anthropometry, and physical activity (2013)

The gene x environment interactions we report suggest that PROGINS alters endometrial sensitivity to maternal energetic condition. Thus, the possibility of genetically-based variation in sensitivity to energetic stress should be considered in future adaptive models of women's reproduction.
Sedimentation velocity characterisation of the cell cycle of granulocytic progenitor cells in monkey hemopoietic tissue (1973)

Abstract Sedimentation velocity separation of Rhesus monkey bone marrow cells has demonstrated a reproducible but heterogeneous size distribution of cells capable of forming granulocytic colonies in agar culture (CFC's). This heterogeneity is shown to be due to the cell cycle status of the progenitor cell population. In vitro exposure of bone marrow cells to lethal doses of tritiated thymidine (H 3 TdR) either before or after separation restricts the size distribution of CFC's, greatly reducing the proportion of rapidly sedimenting cells. The calculation of the volume distribution of such cells before and after H 3 TdR exposure indicates that 55% of total CFC's in adult marrow are in G 0 or G 1 with a volume of 410 μ 3 , 42% are in S phase and of volume 450–950 μ 3 , and the remainder are in G 2 and mitosis with a volume of between 600–950 μ 3 . CFC's in mid gestation fetal liver were larger than their adult counterparts and were of homogeneous volume indicative of a single non cycling population with no evidence of an S or G 2 component. H 3 TdR exposure confirmed the non‐cycling status of these fetal progenitor cells.
Emergence vs. Reductionism. (2012)

Lilienfeld (see record 2011-12007-001) made several cogent points regarding "public skepticism of psychology." He persuasively documented the prevalence of public skepticism with regard to psychology. He also provided sound rebuttals to six common criticisms of psychology. This comment addresses two substantial omissions regarding his discussion of psychology's "Illusion of Understanding" (p. 120) and "Greedy Reductionism" (p. 120).
Pulsed Plasma Gliding-Arc Discharges With Water Spray (2008)

Pulsed gliding-arc discharge (PGD) (25 kV, 18 W, and 170 Hz) was produced between two divergent electrodes using an ignition coil in place of the conventional ac transformer. The time courses of pH, conductivity, and the formation of hydrogen peroxide in pure water with a variety of different carrier gases were determined in the PGD and ac-gliding (ACG)-arc reactors. The energy yield for the destruction of an organic blue dye in the PGD reactor is approximately 150 times higher than in the ACG-arc reactor with Ar carrier, and the energy yields for the formation of hydrogen peroxide are 270 and 260 times higher in the PGD reactor than in the ACG-arc reactor with Ar and 02 carrier gases, respectively.
Emergence and Spread ofChlamydia trachomatisVariant, Sweden (2008)

A variant of Chlamydia trachomatis that had escaped detection by commonly used systems was discovered in Sweden in 2006. In a nationwide study, we found that it is now prevalent across Sweden, irrespective of the detection system used. Genetic analysis by multilocus sequence typing identified a predominant variant, suggesting recent emergence.
Highly Active and Durable Single‐Atom Tungsten‐Doped NiS0.5Se0.5 Nanosheet @ NiS0.5Se0.5 Nanorod Heterostructures for Water Splitting (2022)

Developing robust and highly active non-precious electrocatalysts for the hydrogen/oxygen evolution reaction (HER/OER) is crucial for the industrialization of hydrogen energy. In this study, a highly active and durable single-atom W-doped NiS<sub>0.5</sub> Se<sub>0.5</sub> nanosheet @ NiS<sub>0.5</sub> Se<sub>0.5</sub> nanorod heterostructure (W-NiS<sub>0.5</sub> Se<sub>0.5</sub> ) electrocatalyst is prepared. W-NiS<sub>0.5</sub> Se<sub>0.5</sub> exhibits excellent catalytic activity for the HER and OER with ultralow overpotentials (39 and 106 mV for the HER and 171 and 239 mV for the OER at 10 and 100 mA cm<sup>-2</sup> , respectively) and excellent long-term durability (500 h), outperforming commercial precious-metal catalysts and many other previously reported transition-metal-based compounds (TMCs). The introduction of single-atom W delocalizes the spin state of Ni, which results in an increase in the Ni d-electron density. This causes the optimization of the adsorption/desorption process of H and a significant reduction in the adsorption free energy of the rate-determining step (O* → OOH*), thus accelerating the thermodynamics and kinetics of the HER and OER. This work provides a rational feasible strategy to design single-atom catalysts for water splitting and to develop advanced TMC electrocatalysts by regulating delocalized spin states.
CAFASP2: The second critical assessment of fully automated structure prediction methods (2001)

The results of the second Critical Assessment of Fully Automated Structure Prediction (CAFASP2) are presented. The goals of CAFASP are to (i) assess the performance of fully automatic web servers for structure prediction, by using the same blind prediction targets as those used at CASP4, (ii) inform the community of users about the capabilities of the servers, (iii) allow human groups participating in CASP to use and analyze the results of the servers while preparing their nonautomated predictions for CASP, and (iv) compare the performance of the automated servers to that of the human-expert groups of CASP. More than 30 servers from around the world participated in CAFASP2, covering all categories of structure prediction. The category with the largest participation was fold recognition, where 24 CAFASP servers filed predictions along with 103 other CASP human groups. The CAFASP evaluation indicated that it is difficult to establish an exact ranking of the servers because the number of prediction targets was relatively small and the differences among many servers were also small. However, roughly a group of five "best" fold recognition servers could be identified. The CASP evaluation identified the same group of top servers albeit with a slightly different relative order. Both evaluations ranked a semiautomated method named CAFASP-CONSENSUS, that filed predictions using the CAFASP results of the servers, above any of the individual servers. Although the predictions of the CAFASP servers were available to human CASP predictors before the CASP submission deadline, the CASP assessment identified only 11 human groups that performed better than the best server. Furthermore, about one fourth of the top 30 performing groups corresponded to automated servers. At least half of the top 11 groups corresponded to human groups that also had a server in CAFASP or to human groups that used the CAFASP results to prepare their predictions. In particular, the CAFASP-CONSENSUS group was ranked 7. This shows that the automated predictions of the servers can be very helpful to human predictors. We conclude that as servers continue to improve, they will become increasingly important in any prediction process, especially when dealing with genome-scale prediction tasks. We expect that in the near future, the performance difference between humans and machines will continue to narrow and that fully automated structure prediction will become an effective companion and complement to experimental structural genomics.
Evaluation of Sample Preparation Methods for Inter-Laboratory Metabolomics Investigation of Streptomyces lividans TK24 (2020)

In the past two decades, metabolomics has proved to be a valuable tool with many potential applications in different areas of science. However, there are still some challenges that need to be addressed, particularly for multicenter studies. These challenges are mainly attributed to various sources of fluctuation and unwanted variations that can be introduced at pre-analytical, analytical, and/or post-analytical steps of any metabolomics experiment. Thus, this study aimed at using <i>Streptomyces lividans</i> TK24 as the model organism in a cross-laboratory experiment in Manchester and Leuven to evaluate the reproducibility of a standard sample preparation method, and determine the optimal sample format (cell extract or quenched biomass) required to preserve the metabolic profile of the cells during cross-lab sample transportation and storage. Principal component analysis (PCA) scores plot of the gas chromatography-mass spectrometry (GC-MS) data from both laboratories displayed clear growth-dependent clustering patterns which was in agreement with the Procrustes analysis findings. In addition, the data generated in Manchester displayed tight clustering of cell pellets (quenched biomass) and metabolite extracts, confirming the stability of both sample formats during the transportation and storage period.
Predictive value of negative 3T multiparametric magnetic resonance imaging of the prostate on 12‐core biopsy results (2016)

A negative prebiopsy mpMRI confers an overall NPV of 82% on 12-core biopsy for all cancer and 98% for GS ≥7 cancer. Based on biopsy indication, these findings assist in prebiopsy risk stratification for detection of high-risk disease and may provide guidance in the decision to pursue biopsy.
A note on Bipartite Eulerian Planar Maps (2001)

Rapport interne.
Adaptive Real-Time Pattern Recognition Using Liquid Crystal Televisions (1987)

Recently many applications of the liquid crystal television (LCTV) to real-time signal processing have been reported. A basic description of the application of the LCTV to real-time pattern recognition was first reported by Liu et al. [1]. Gregory [2] later also showed a successful space invariant correlation using a LCTV as a spatial light modulator. Both methods were based on the use of a VanderLugt type complex matched spatial filter. The joint transform architecture is an alternative approach to optical pattern recognition [3]. In this paper, a new implementation of the real-time monochromatic and polychromatic joint transform correlator architecture using inexpensive LCTVs will be discussed.
A comparison of different heart rate deflection methods to predict the anaerobic threshold (2008)

Abstract There is perhaps no greater controversy in exercise physiology than the validity, or lack thereof, of the heart rate breakpoint theory in general, and the Conconi test in particular, in assessing the anaerobic threshold. Three heart rate breakpoint methods have been proposed as methods of detecting the anaerobic threshold have appeared in the literature: (1) a breakpoint in linearity of the heart rate–work rate relationship (heart rate breakpoint); (2) a log function curve of the heart rate–work rate relationship (log function); and (3) a combination of linear regression and logarithmic function of the heart rate–work rate relationship (log‐linear). The main aim of this study was to assess the validity of these methods compared with that of gas analysis assessment of the anaerobic threshold. This was a descriptive study of 115 endurance athletes undergoing simultaneous gas analysis and heart rate determination during incremental exercise to exhaustion. The participants were 115 competitive cyclists and/or triathletes (71 males: mean age 38.5 years, s =6.2; 44 females: mean age 37.8 years, s =5.1). Incremental exercise testing to exhaustion was performed on an electrically braked cycle ergometer, commencing at 25 W and increasing by 25 W · min −1 to volitional fatigue. Heart rate was recorded each minute and at exhaustion. Gas analysis was performed using breath‐by‐breath analysis with 10‐s averaging. The anaerobic threshold based on ventilatory parameters was used as the criterion test. Compared with the criterion threshold, no significant differences were observed for the heart rate breakpoint ( t =1.12, P =0.268) or log function ( t= 0.0, P =0.998) methods. However, the log‐linear method ( t= 2.25, P =0.026) significantly overestimated the anaerobic threshold. Although two of the three heart rate methods were validated in this study, the relatively large total errors for these methods (13.7 beats · min −1 for heart rate breakpoint, 12.5 beats · min −1 for log function, and 14.3 beats · min −1 for log‐linear) indicate that they would have little practical value.
Hirsutellones A—E, Antimycobacterial Alkaloids from the Insect Pathogenic Fungus Hirsutella nivea BCC 2594. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
CD8 Tregs Promote Gvhd Prevention and Restore Impaired GVL Effect Mediated By CD4 Tregs in Mice (2015)

Abstract Adoptive regulatory T-cell (Treg) therapy has enhanced the outcome of patients suffering from graft-versus-host (GVH) disease following allogeneic hematopoietic stem cell transplantation (allo-HCT); however, fear of broad immune suppression and subsequent dampening of the beneficial graft-versus-leukemic (GVL) responses remains a challenge. In order to subvert broad immune suppression, we generated alloantigen-specific induced Tregs (iTregs) from resting CD4 or CD8 T cells and tested the ability of iTregs to suppress GVH and maintain GVL responses. We utilized a clinically relevant murine model of haploidentical-HCT with the addition of host-original leukemia cell line to evaluate the effects of CD4 and CD8 iTregs in GVH and GVL responses. While alloantigen-specific CD4 iTregs were effective in preventing GVHD (Fig. 1 A and C), they completely abrogated the GVL effect against aggressive leukemia resulting in 100% tumor mortality (Fig. 1 B and D). Mechanistically, these CD4 iTregs were found to potently suppress the expansion of effector T cells (Teffs) and their ability to secrete IFNγ and granzyme B in the recipient spleen and liver, which may contribute to the impaired GVL activity. Using similar approach, we generated alloantigen-specific CD8 iTregs and found they express higher levels of granzyme B and CTLA-4 compared to nTreg and CD4 iTregs. In vivo studies showed these CD8 iTregs moderately attenuated GVHD (Fig. 1 A and C)while completely sparing the GVL effect (Fig. 1 B and D). We thus further reasoned that the combination of CD4 and CD8 iTregs could achieve the optimal goal of allo-HCT: GVHD suppression with GVL preservation. Indeed, the combination therapy potently suppressed GVHD resulting in increased survival and decreased pathological injury to target organs than either CD4 or CD8 iTreg singular therapy (Fig. 1 A and C). More importantly, the combination therapy maintained potent GVL responses reflected by significantly decreased tumor mortality and load (Fig. 1 B and D).Mechanistically, we observed addition of CD8 iTregs maintained the suppression of Teff expansion but restored the ability of Teffs in producing inflammatory cytokines (e.g. IFNγ and TFNα) and cytolytic effector molecules (e.g. granzyme B and TRAIL). To our knowledge the current findings are the first to support the use of combinational iTreg therapy to achieve optimal suppression of GVHD while maintaining GVL responses. This work was supported by NIH grants: R01 CA118116 and R01 CA169116 Disclosures No relevant conflicts of interest to declare.
Estimation of Current and Sag in Overhead Power Transmission Lines With Optimized Magnetic Field Sensor Array Placement (2017)

Power distribution mechanism in smart grid necessitates the development of an easy-to-install and contactless sensing system to monitor the operational state of overhead high-voltage transmission lines. Here, we propose a robust phase current and sag estimation method at support structures. Novelty in our work is the use of dual-axis magnetic field (MF) sensors equal to the number of phase conductors. This is realized by installing an array of sensors optimally placed in the same vertical plane as of conductors on the tower. The optimal position of sensor array was found while minimizing the condition number of governing linear system close to unity. For any circuit configuration, our method processes the sensed MF vector projections through a linear system, which is based on the Biot-Savart law. It considers the practical factors, such as sag, span length, and sensor-to-conductor distance. An algorithm is then designed to estimate the electric current and sag by iterative comparison between the measured and calculated MF. The method is first tested by numerical simulations for a typical one-circuit configuration, which involves three scenarios of symmetrical and unsymmetrical sag in conductors. The algorithm converges to a maximum error of ≤1% within 300 iterations. We then experimentally verify our scheme on a scaled laboratory setup. Retrieved current and sag values were verified with the readings from ammeter and vernier caliper, respectively. The results prove the viability of our approach within ≤2.6% deviation for current and ≤1% for sag in all conductors.
Adeno-Associated Virus Vector Delivery to the Heart (2011)

Cardiac gene transfer may serve as a novel therapeutic approach in the treatment of heart disease. For it to reach its full potential, methods for highly efficient cardiac gene transfer must be available to investigators so that informative preclinical data can be collected and evaluated. We have recently optimized AAV-mediated cardiac gene transfer protocols in both the mouse and rat. In the mouse, we have developed a procedure for intrapericardial delivery of vector in the neonate and successfully applied intravenous injections in adult animals. In the rat, we have developed a procedure for direct injection of vector into the myocardium in adults and established a protocol for vector delivery into the left ventricular anterior wall by ultrasound-targeted destruction of microbubbles loaded with AAV. Each protocol can be used to achieve safe and efficient cardiac gene transfer in the model of choice.
Shear Stress Gradients Remodel Endothelial Monolayers in Vitro via a Cell Proliferation-Migration-Loss Cycle (1997)

Wall shear stress has been implicated in the genesis of atherosclerosis because a strong correlation exists between the location of developing arterial lesions and regions where particular gradients in stress occur. Studying the behavior of endothelial cells in such regions may contribute to our understanding of the disease etiology. We report the detailed migratory history of endothelial cells subjected to large shear stress gradients caused by a surface protuberance in an in vitro model system. The history of cell migration, cell division, and cell loss from the surface was continuously monitored in confluent human umbilical vein endothelial cell monolayers for 48 hours after the onset of flow. Individual cells were tracked using time-lapse video microscopy. In contrast to a uniform laminar flow field in which cells were observed to continually rearrange their relative position with no net migration, in a disturbed flow field there was a net migration directed away from the region of high shear gradient. This organized migration pattern under disturbed flow conditions was accompanied by more than a twofold increase in cell motility. In addition, cell division increased in the vicinity of the flow separation (maximum shear stress gradient of 34 dyne/cm2 per mm) whereas cell loss was increased upstream and downstream in the regions where the shear gradient diminishes. These data suggest a steady cell proliferation-migration-loss cycle and indicate that local shear stress gradient may play a key role in the morphological remodeling of the vascular endothelium in vivo.
Preparation and hydrogen pumping characteristics of BaCe{sub 0.8}Y{sub 0.2}O{sub 3-delta} thin film. (2005)

Thin films of BaCe{sub 0.8}Y{sub 0.2}O{sub 3-d} (BCY) were prepared by colloidal spray deposition. Dense, crack-free BCY films having a grain size of 2-7 {micro}m were successfully deposited on NiO/BCY substrates. Electrochemical hydrogen pumping with the BCY films showed that the maximum current density increased with temperature. The maximum current density was sensitive to the moisture in the cathode gas; the value obtained with a dry cathode gas was only half that with a wet cathode gas. A very high hydrogen-pumping current density of 3.4 A/cm{sup 2} was measured at 700 C with an applied voltage of 1.5 V.
Recombinant activated protein C treatment improves tissue perfusion and oxygenation in septic patients measured by near-infrared spectroscopy (2009)

Treatment with rh-aPC may improve muscle oxygenation (StO2 baseline) and reperfusion (StO2 upslope) and, furthermore, rh-aPC treatment may increase tissue metabolism (StO2 downslope). NIRS is a simple, real-time, non-invasive technique that could be used to monitor the effects of rh-aPC therapy at microcirculatory level in septic patients.
Constructive shearwave imaging: Feasibility and improvements in SNR (2017)

Shear wave elasticity imaging (SWEI) measures mechanical properties of tissues and has been used to characterize tissue stiffness, but SWEI is limited by low displacement SNR in stiff media such as skin. A method for repeatable measurement of skin elasticity is critical for longitudinal monitoring of sclerotic diseases such as morphea. Constructive Shearwave Interference (CSI) overcomes the SNR limitations of conventional SWEI in skin by generating greater shear wave displacements at the constructive center of an acoustic radiation force ring of excitation. The objective of this study is to characterize the increase in displacement SNR from constructively-interfering shear waves.
Technologie d'optique intégrée polymère au laboratoire FOTON (2014)

Cet article resume le panorama de l'etat de l'art des technologies d'optique integree polymere maitrisees au laboratoire Foton (Systemes Photoniques) et qui sont axees sur des circuits optiques actifs et passifs. Les objectifs sont orientes vers un fort confinement du mode de propagation, la generation d'effets non lineaires, l'hybridation avec d'autres materiaux et la reduction des pertes (couplage et propagation).