gebhart/patrepeval huggingface dataset:
Isolation and sequence of the gene for iso-2-cytochrome c in Saccharomyces cerevisiae. (1980)

The two apocytochrome c proteins of yeast are coded for by separate genes. Iso-2-cytochrome c differs from the iso-1 protein at 17 positions within a homologous sequence of 108 amino acids. The previously cloned iso-1-cytochrome c coding sequence has been used to identify lambda-yeast recombinant phage containing the gene for iso-2-cytochrome c. The latter protein contains the dipeptide Ala-Ala which is coded for by the nucleic acid sequence G-C-N-G-C-N. The recognition specificity of restriction endonuclease Fnu4HI for G-C-N-G-C provided a rapid means of locating the region of the cloned fragment which codes for iso-2-cytochrome c. The DNA sequence of this gene has been determined and compared with that of the iso-1-cytochrome c locus. There is no intervening sequence within the gene for iso-2-cytochrome c. At 45 of the 91 positions for which iso-1- and iso-2-cytochrome c have the same amino acid, the codons differ. Such third position variation does not occur within the region coding for amino acids 70-80, the protein sequence that is also most conserved among all eukaryotic cytochromes c.
Large Anomalous Nernst Effect in a van der Waals Ferromagnet Fe3GeTe2 (2019)

Anomalous Nernst effect, a result of charge current driven by temperature gradient, provides a probe of the topological nature of materials due to its sensitivity to the Berry curvature near the Fermi level. Fe<sub>3</sub>GeTe<sub>2</sub>, one important member of the recently discovered two-dimensional van der Waals magnetic materials, offers a unique platform for anomalous Nernst effect because of its metallic and topological nature. Here, we report the observation of large anomalous Nernst effect in Fe<sub>3</sub>GeTe<sub>2</sub>. The anomalous Hall angle and anomalous Nernst angle are about 0.07 and 0.09, respectively, far larger than those in common ferromagnets. By utilizing the Mott relation, these large angles indicate a large Berry curvature near the Fermi level, consistent with the recent proposal for Fe<sub>3</sub>GeTe<sub>2</sub> as a topological nodal line semimetal candidate. Our work provides evidence of Fe<sub>3</sub>GeTe<sub>2</sub> as a topological ferromagnet and demonstrates the feasibility of using two-dimensional magnetic materials and their band topology for spin caloritronics applications.
Si‐, Ge‐, Sn‐Based Anode Materials for Lithium‐Ion Batteries: From Structure Design to Electrochemical Performance (2017)

As state‐of‐the‐art rechargeable energy‐storage devices, lithium‐ion batteries (LIBs) are widely applied in various areas, such as storage of electrical energy converted from renewable energy and powering portable electronic devices and electric vehicles (EVs). Nevertheless, the energy density and working life of current commercial LIBs cannot satisfy the rapid development of these applications. It is urgently required that the electrochemical performance of LIBs, which is mainly determined by the electroactive electrode materials, is improved. However, commercial graphite‐based anode materials deliver a relatively low theoretical capacity of 372 mA h g −1 , severely hindering the increase of the energy density of LIBs. Recently, M‐based anode (M represents Si, Ge, and Sn) materials have attracted great attention due to their high theoretical capacity and reasonable anodic voltage. However, the application of M‐based anode materials is seriously limited by a series of several critical problems, such as poor kinetics and huge volume change on cycling. Here, these fundamental problems leading to poor electrochemical performance are discussed, and a series of reasonable nanostructures for M‐based anodes with improved electrochemical performance is summarized, demonstrating that the dimensional control in structure design plays a critical role for solving these problems.
Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci (2014)

We used a collection of 708 prospectively collected autopsied brains to assess the methylation state of the brain's DNA in relation to Alzheimer's disease (AD). We found that the level of methylation at 71 of the 415,848 interrogated CpGs was significantly associated with the burden of AD pathology, including CpGs in the ABCA7 and BIN1 regions, which harbor known AD susceptibility variants. We validated 11 of the differentially methylated regions in an independent set of 117 subjects. Furthermore, we functionally validated these CpG associations and identified the nearby genes whose RNA expression was altered in AD: ANK1, CDH23, DIP2A, RHBDF2, RPL13, SERPINF1 and SERPINF2. Our analyses suggest that these DNA methylation changes may have a role in the onset of AD given that we observed them in presymptomatic subjects and that six of the validated genes connect to a known AD susceptibility gene network.
Assistive Technologies for Biologically Inspired Controller System - A Short Review Assistive Technologies for the Elderly (2019)

Ageing is inevitable and leads to numerous problems including disabilities in the lower limb. Partial disabilities represent a severe challenge to many people; occur due to debilitative disorder including muscular dystrophy, accidents, stroke and other age-related issues. This problem commonly occurs in developing nations which results in lack of their development so the physiotherapist has taken many measures and recent innovation in assistive technology are very much useful. Recent developments in the field of robotics lead to the innovation of assistive devices in the rehabilitation process and assistive services. This paper gives brief literature about the methods used in assistive technology and how good they are interacting with the user. The review suggests that the human-robot interface is brought by a co-adaptive system which can be adopted by all models. The simulation process is carried out in software's like mat lab and proteus before proceeding to the hardware simulation.
Retrograde Reamed Femoral Nailing (2014)

Closed, reamed, antegrade nailing remains the standard of care for femoral shaft fractures. This technique however, may be less attractive in the management of femoral shaft fractures associated with (a) ipsilateral acetabular, pelvis, or femoral neck fractures; (b) poly trauma requiring multiple simultaneous surgical procedures; and (c) pregnancy. We now report on our experience with the retrograde femoral nailing as a treatment option in these situations. Between 4/88 and 10/90, 29 retrograde femoral nailing in 24 patients were attempted. Average age was 29.3 (16-74) years. Five fractures were open. Fracture location was isthmal in 14 and infraisthmal in 15. The comminution was classified according to Winquist and Hansen: I(10), II(7), III(7), and IV(5). Nailing was possible in 28/29 cases. Insertion was made through an extraarticular medial condylar portal. Nail diameter ranged from 10 to 13 mm. An AO Universal Femoral Nail was used in the first 11 cases; all subsequent fractures were stabilized using an AO Universal Tibial Nail because its design appeared better suited to this technique. Follow-up was possible for 25 fractures in 21 patients and averaged 16.0 (range, 11-27); months 23/25 (92%) fractures healed within 12 weeks. No case was associated with an infection, loss of reduction, or nail failure. Knee flexion averaged 122°; only two knees had an extensor lag of >5°. Intraoperative complications included three cases of crack propagation at the insertion site, and four infraisthmal malreductions (two valgus, two flexion). Based on these results, we feel that retrograde reamed femoral nailing is a suitable alternative to antegrade nailing and should be considered in situations where proximal access is neither possible nor desirable.
LEARNING AS CHOICE: INTERACTIVE DYNAMIC DECISION-MAKING (2016)

S. DugalP. IturraldeH. StampO. Abd El AzizN. AmodeoZ. ArnoldA. DavisR. DoorleyA. DyerD. GuglielmoM. HaganA. HayesL. HupalJ. IannoneE. JacobsS. KaiserT. KuehlkeJ. LabeA. LapriseC. LomolinoS. RannB. RyanM. SantagataM. SlubyY. Vajifdar
Neurotrophin receptor TrkB promotes lung adenocarcinoma metastasis (2014)

Lung cancer is notorious for its ability to metastasize, but the pathways regulating lung cancer metastasis are largely unknown. An in vitro system designed to discover factors critical for lung cancer cell migration identified brain-derived neurotrophic factor, which stimulates cell migration through activation of tropomyosin-related kinase B (TrkB; also called NTRK2). Knockdown of TrkB in human lung cancer cell lines significantly decreased their migratory and metastatic ability in vitro and in vivo. In an autochthonous lung adenocarcinoma model driven by activated oncogenic Kras and p53 loss, TrkB deficiency significantly reduced metastasis. Hypoxia-inducible factor-1 directly regulated TrkB expression, and, in turn, TrkB activated Akt signaling in metastatic lung cancer cells. Finally, TrkB expression was correlated with metastasis in patient samples, and TrkB was detected more often in tumors that did not have Kras or epidermal growth factor receptor mutations. These studies demonstrate that TrkB is an important therapeutic target in metastatic lung adenocarcinoma.
Supplementary Figure 1 from Novel Chemosensitive Single-Nucleotide Polymorphism Markers to Targeted Regimens in Metastatic Colorectal Cancer (2023)

&lt;p&gt;PDF file - 376K, Inhibition rates (IR) of tumor growth (A) and response rates at IR30 (chemosensitivity) (B). The IRs and IR30 of a single bevacizumab or cetuximab regimen were significantly less than those of the other four combination regimens (P � 0.001). IR, inhibition rate; FRB, FOLFIRI + bevacizumab; FXB, FOLFOX + bevacizumab; FRC, FOLFIRI + cetuximab; FXC, FOLFOX + cetuximab.&lt;/p&gt;
Germ cell neoplasia in situ (GCNIS): evolution of the current nomenclature for testicular pre‐invasive germ cell malignancy (2016)

The pre-invasive lesion associated with post-pubertal malignant germ cell tumours of the testis was first recognized in the early 1970s and confirmed by a number of observational and follow-up studies. Until this year, this scientific story has been confused by resistance to the entity and disagreement on its name. Initially termed 'carcinoma in situ' (CIS), it has also been known as 'intratubular germ cell neoplasia, unclassified' (IGCNU) and 'testicular intraepithelial neoplasia' (TIN). In this paper, we review the history of discovery and controversy concerning these names and introduce the reasoning for uniting behind a new name, endorsed unanimously at the World Health Organization (WHO) consensus classification 2016: germ cell neoplasia in situ (GCNIS).
Design, modeling and testing of integrated ring extractor for high resolution electrohydrodynamic (EHD) 3D printing (2017)

This paper presents an integrated ring extractor design in electrohydrodynamic (EHD) printing, which can overcome the standoff height limitation in the EHD printing process, and improve printing capability for 3D structures. Standoff height in the EHD printing will affect printing processes and limit the height of the printed structure when the ground electrode is placed under the substrate. In this work, we designed and integrated a ring electrode with the printing nozzle to achieve a self-working printer head, which can start and maintain the printing process without the involvement of the substrate. We applied a FEA method to model the electric field potential distribution and strength to direct the ring extractor design, which provides a similar printing capability with the system using substrate as the ground electrode. We verified the ring electrode design by experiments, and those results from the experiments demonstrated a good match with results from the FEA simulation. We have characterized the printing processes using the integrated ring extractor, and successfully applied this newly designed ring extractor to print polycaprolactone (PCL) 3D structures.
Analysis of Hollinshed Watershed Using GIS Software (1999)

The objective of this study is to apply GIS and storm water modeling software to develop an accurate hydrologic model of the Hollinshed watershed. Use of GIS will allow the user to quickly change the land use of specific areas within in the watershed to determine the hydrologic effects throughout the watershed using the storm water model. Specific objectives were to: (1) develop a GIS database for the Hollinshed watershed; (2) Develop an appropriate link/node diagram and corresponding input file for the storm water model Drain:Hydro(registered); and (3) Study impact caused by current and future development on the storm water runoff in the watershed.
Addition reactions of N-bromoperfluoromethanamine with some olefins (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAddition reactions of N-bromoperfluoromethanamine with some olefinsShiching Chang and Darryl D. DesMarteauCite this: J. Org. Chem. 1983, 48, 6, 895–897Publication Date (Print):March 1, 1983Publication History Published online1 May 2002Published inissue 1 March 1983https://doi.org/10.1021/jo00154a034RIGHTS & PERMISSIONSArticle Views73Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (487 KB) Get e-Alerts Get e-Alerts
QLIM -- A Tool to Support Collective Intelligence (2012)

Creativity and capabilities of innovation are often desirable goals of interactions between people. This involves actors to be open, receptive as well as communicative. In this paper we propose a tool named QLIM that aims to support collective intelligence through tailor ability, by allowing participants to continue the construction of a questionnaire while being used. After a state of the art, we present QLIM features and architecture, then we present the experiments we conducted and the hypotheses that they inspired to us. The main goal of this paper is to show how QLIM helps us to understand the group interactions and how it can help to support collective intelligence.
Highly integrated 2-D capacitive micromachined ultrasonic transducers (2003)

Two dimensional (2-D) silicon based capacitive micromachined ultrasonic transducer (cMUT) arrays are fabricated efficiently using standard integrated circuit (IC) processing techniques. Furthermore, high density interconnects are implemented using through-chip vias which bring the signal from the front surface of the transducer chip to the back side. The transducer chip then can be flip-chip bonded to a signal processing chip. This results in a very compact two chip hybrid package that can be easily sealed for immersion applications. The electrical interconnects are realized by high aspect ratio vias (50 /spl mu/m in diameter, 550 /spl mu/m in depth) that are etched into the silicon substrate by a deep reactive ion etcher (DRIE). The vias are then coated by polysilicon which is subsequently doped to achieve good conductivity. The transducer arrays are then built on the front side using the conventional process developed for cMUTs. Measurements indicate that the through wafer vias have a typical resistance of 7 /spl Omega/. The parasitic via capacitances are reduced to 2 pF by reverse biasing the p-n junction formed by the n++ doped polysilicon via coating and the near-intrinsic p-type silicon substrate. Ultrasonic measurements on the 2-D array cMUT elements with these interconnects shows more than 100% fractional bandwidth and high sensitivity.
Voigt Exceptional Points in an Anisotropic ZnO-Based Planar Microcavity: Square-Root Topology, Polarization Vortices, and Circularity (2019)

Voigt points represent propagation directions in anisotropic crystals along which optical modes degenerate, leading to a single circularly polarized eigenmode. They are a particular class of exceptional points. Here, we report the fabrication and characterization of a dielectric, anisotropic optical microcavity based on nonpolar ZnO that implements a non-Hermitian system and mimics the behavior of Voigt points in natural crystals. We prove the exceptional-point nature by monitoring the complex-square-root topology of the mode eigenenergies (real and imaginary parts) around the Voigt points. Polarization state analysis shows that these artificially engineered Voigt points behave as vortex cores for the linear polarization and sustain chiral modes. Our findings apply to any planar microcavity with broken cylindrical symmetry and, thus, pave the way for exploiting exceptional points in widespread optoelectronic devices such as vertical cavity surface emitting lasers and resonant cavity light emitting diodes.
Fully Integrated Passive Front-End Solutions for a V-band LTCC Wireless System (2007)

A novel topology implementing a 3-D fully integrated filter and antenna function is proposed as a system-on-package (SOP) compact front-end solution for the low-temperature cofired ceramic (LTCC) based V-band modules. A 4-pole quasi-elliptic bandpass filter composed of four open loop resonators has been developed. It exhibits an insertion loss <3.5 dB, a return loss >15 dB over the pass band (~3.4 GHz) and a 3 dB bandwidth of about 5.46% (~3.4 GHz) at the center frequency of 62.3 GHz. In addition, a series fed 1 4 linear antenna array of four microstrip patches exhibiting high gain and fan-beam radiation pattern has been designed. Its 10 dB bandwidth is experimentally validated to be 55.4-66.8 GHz (~18.5%). The above proposed designs have been combined together, leading to the complete integration of passives with a high level of selectivity over the band of interest. The excellent overall performance of the integrated solution is verified through a 10-dB bandwidth of 4.8 GHz (59.2-64 GHz) and a return loss >10.5 dB over the passband.
D. HÉLDER, O VATICANO II E OS “SINAIS DOS TEMPOS”: Tradição e modernidade no Concílio - DOI 10.5752P.2316-9451.2013v8n13p57 (2013)

Dom Hélder Câmara ocupa uma posição de destaque na história do catolicismo brasileiro devido à sua participação destacada em diversos eventos marcantes do século XX: a organização de movimentos de leigos católicos antes de 1950, a fundação da CNBB (Conferência Nacional dos Bispos do Brasil) em 1952, a fundação do CELAM (Conselho Episcopal Latino Americano) em 1955, a participação ativa no Concílio Vaticano II, a oposição à ditadura militar e a conjugação entre a Teologia da Libertação com a proposta da “não-violência ativa” (inspirada em Gandhi). Em sua vida de intensa vivência do cristianismo católico podemos identificar a constante presença de uma das mais interessantes facetas da Igreja Católica, em seus quase dois mil anos de existência: a interpretação dos sinais dos tempos como leitura e motivação da missão do cristianismo na história.
Driver Behavior in Pedestrian Crash Scenarios (2016)

While pedestrian injuries account for only a small percentage of traffic injuries, they disproportionately account for 12% of traffic related fatalities. The goal of the present study was to understand how different situational factors affect drivers’ responses to crash imminent situations involving pedestrians in a high-fidelity, full-motion simulator. Forty-eight drivers encountered eighteen pedestrian crash scenarios that systematically manipulated four factors: location, driver expectation, side of the street, and crossing speed. These factors were derived from a review of the pedestrian crash literature. The results showed that mid-block events were harder to avoid than intersection events, resulting in harder braking and more collisions. Side of the street and driver expectation also influenced how drivers responded. These findings demonstrate that many factors influence how a driver responds to a crossing pedestrian, with factors affecting driver expectancy appearing to play a very significant role. These results can be used to inform pedestrian detection/avoidance systems in intelligent vehicles. Future research should address additional factors that might further explain driver-pedestrian crashes, such as driver distraction.
Characterization of Ossicular Chain Vibration at the Umbo: Implications for a Middle Ear Microelectromechanical System Design (2010)

We propose the use of a microelectromechanical system (MEMS) accelerometer as a middle ear microphone for future totally implantable cochlear prostheses. The MEMS accelerometer would be attached to the umbo to detect and convert the natural bone vibration that occurs in response to external sounds into an electrical signal that represents the acoustic information. The signal could be further processed to stimulate cochlear implant electrodes. To determine the feasibility of our proposal, we conducted a study to investigate whether the characteristics of umbo vibration along two orthogonal axes-one axis being perpendicular to the tympanic membrane and the other axis being parallel to the tympanic membrane plane but orthogonal to the long process of the malleus-differ significantly enough to compromise the sensing performance of the proposed accelerometer should a position misalignment occur during the implant procedure. We used laser Doppler vibrometry to measure the displacement of the umbo along the two orthogonal axes in 4 cadaveric temporal bones at multiple frequencies within the audible spectrum. We found that the peak-to-peak displacement frequency response along both axes was nearly flat from 250 Hz to 1 kHz, and it gradually rolled off with a slope of approximately -20 dB and -40 dB per decade above 1 kHz and 4 kHz, respectively. At each frequency, the displacement exhibited a linear function of the input sound level with a slope of 20 dB per decade. A comparison of measurements along the two axes indicated a similar frequency response, with an average amplitude difference of 20%. The characterization data suggest that the performance of a miniature ossicular vibration-sensing device attached on the umbo would not be degraded in the event of a position misalignment. The data also indicate that a MEMS accelerometer needs to achieve a resolution of 35 i g/sqrt[Hz] to detect normal conversation.
Dural Repair Using Acellular Human Dermis: Experience with 200 Cases: Technique Assessment (2000)

AlloDerm is a reasonable alternative to the available dural graft materials. Its handling characteristics are similar to those of dura, it is biologically inert, and it does not produce adhesion formation.
ANALYZING THE RELATIONSHIP BETWEEN MONETARY RESERVES AND COUNTRY POLITICAL RISK: A MODEL FOR SMALL AND MEDIUM‐SIZED MNCs (1994)

In this study a relationship between the fluctuation of a nation's monetary reserves and political risk is established. A least square regression model is used for the 1972–87 period and monetary reserves fluctuations of nineteen countries are analyzed. It is concluded that monetary reserves data can be used as a cost efficient proxy for political risk in moderate risk non‐oil exporting countries. Less politically risky countries also exhibit a positive relationship but the results are not statistically significant. This study has special implications for small and medium‐sized corporations. Further, the limitations of this study are discussed.