gebhart/patrepeval huggingface dataset:
Leukocyte transendothelial migration: A local affair (2016)

Inflammation is part of the complex biological response of body tissues to harmful stimuli, such as pathogens. It serves as a protective response that involves leukocytes, blood vessels and molecular mediators with the purpose to eliminate the initial cause of cell injury and to initiate tissue repair. Inflammation is tightly regulated by the body and is associated with transient crossing of leukocytes through the blood vessel wall, a process called transendothelial migration (TEM) or diapedesis. TEM is a close collaboration between leukocytes on one hand and the endothelium on the other. Limiting vascular leakage during TEM but also when the leukocyte has crossed the endothelium is essential for maintaining vascular homeostasis. Although many details have been uncovered during the recent years, the molecular mechanisms from the vascular part that drive TEM still shows significant gaps in our understanding. This review will focus on the local signals that are induced in the endothelium that regulate leukocyte TEM and simultaneous preservation of endothelial barrier function.
Validation and Quantitative Assessment of the Deterioration Mechanisms of Arctic Icebergs (1987)

In this paper the important mechanisms affecting the deterioration of Arctic icebergs are modeled based on parameterizations developed for the International Ice Patrol. The model simulations of the deterioration of three icebergs in the Grand Banks/Labrador Sea area off the Canadian east coast are compared with observations. The model parameterizations provide a reasonable approximation of iceberg deterioration with best results being obtained where detailed observations of the above-water and underwater portions of the iceberg are available enabling accurate estimations of iceberg mass and other parameters needed for the model. A quantitative assessment of the deterioration of icebergs in the Grand Banks/Labrador Sea area is also carried out for each month of the year when the sea surface temperature was above zero. Wave erosion is found to be the major deterioration mechanism. Wave erosion and the resulting calving of overhanging slabs together account for more than 80 percent of the deterioration rate. A small iceberg drifting on the Grand Banks could lose up to one third of its mass in one day.
Dynamic band-structure modulation of quantum wells by surface acoustic waves (2001)

The dynamical modulation of the band structure of GaAs quantum wells by a surface acoustic wave (SAW) is investigated using photoluminescence (PL) spectroscopy. The strain field of the SAW modulates the excitonic transitions, leading to a splitting and to a polarization anisotropy of the excitonic PL lines. The oscillator strength of the split line gives direct information about the spatial distribution of carriers in the potential modulation induced by the SAW.
A Study of the Anchorage loss of Ground Anchor Using Spacing Apparatus and Spring for Soil Structure Stability (2006)

A ground anchor system is used as a load carrying element for soil structure stability The conventional systems with ground anchors bring about the anchorage loss of wedges when anchors are installed for the support of soil structures. Hence we developed the new type of anchor system using both the spacing apparatus and spring (length 60mm, diameter 6mm). In this system, we can directly check the condition of wedges and PS strands and modify the problems with the slip and anchorage of wedges under construction. For demonstrating the superiority of this system, we carried out a series of both laboratory and field test. Consequently, we can obtain satisfactory result (18.99% reduction to the loss of conventional systems). Moreover, the replacement of wedges is easy and simple when retensioning of strands.
A generic attack on hashing-based software tamper resistance (2005)

lnternet, preter, distribuer et vendre des theses partout dans le monde, a des fins commerciales ou autres, sur support microforme, papier, electronique et/ou autres formats.
Enhancing intensity and refractive index sensing capability with infrared plasmonic perfect absorbers (2014)

An infrared refractive index sensor based on plasmonic perfect absorbers for glucose concentration sensing is experimentally demonstrated. Utilizing substantial absorption contrast between a perfect absorber (∼98% at normal incidence) and a non-perfect absorber upon the refractive index change, a maximum value of figure of merit (FOM<sup>*</sup>) about 55 and a bulk wavelength sensitivity about 590 nm/RIU are achieved. The demonstrated sensing platform provides great potential in improving the performance of plasmonic refractive index sensors and developing future surface enhanced infrared spectroscopy.
A fatal case of gun blue ingestion in a toddler. (2000)

Acute selenium poisoning occurs infrequently. The form of selenium encountered plays a great role in toxicity. Several fatalities have been reported and all but I involved ingestion of selenious acid or selenium dioxide. A healthy 22-mo-old male ingested up to 15 ml of Gun Blue solution (selenious acid). Initially he was pink, alert, and combative in the ambulance but his condition rapidly deteriorated. There was no measurable blood pressure, his oxygen saturation was 84% by pulse oximetry, and his mental status deteriorated to require hand ventilation. The child was cyanotic, unresponsive, and without palpable pulses upon presentation. Cardiopulmonary resuscitation was initiated unsuccessfully and was terminated after 35 minutes.
Studies on the Bacterial Spore Coat: IX. The Role of Surface Charge in Germination of Bacillus megaterium Spores (1981)

The surface charge of Bacillus megaterium QM B1551 spores was estimated to be negative, -0.2 ad -0.4 mueq/mg by colloidal titration using glycol chitosan (GCh) and methylglycol chitosan (MGCh), respectively, as positive colloids. MGCh, which reacts with all of the negatively charged groups including carboxylate, inhibited the second stage of the germination to result in semirefractile spores, but GCh, which reacts only with strong acidic groups such as phosphate, did not. The spores produced in a medium with limited phosphate had coats with low phosphate content and carried less negative charge, and they were induced to germinate with 0.4 mM KNO3, which is one-tenth of the minimum concentration required for the germination of the control spores. A similar increase in germinability was observed in spores incubated with calcium acetate. The results suggest that the role of the surface charge in germination is as follows. Strong acidic groups (such as phosphate) in the coat may block the action of ionic germinants and act as a barrier against the initiation of ionic germination. Positively charged compounds (such as calcium) may compensate for this blocking effect. Weak acidic groups (such as carboxylate) may be involved in the later stage of germination.
Application of static magnetic field to casting of steel (2018)

A magnetic field was applied in the continuous caster in steelmaking. A static magnetic field has advantages in the steelmaking processes, in that the apparatus for generating a static magnetic field is simpler than alternating magnetic coils, and stabilization of the flow is enhanced by a static magnetic field because a larger force acts on a faster steel flow. Therefore, application to industrial processes has been investigated. In this presentation, two applications are discussed, as follows: 1) Steel flow control in mold The steel flow is controlled in the mold to produce high quality steel products with high productivity. An unbalanced steel flow causes surface defects. A static magnetic field is effective for stabilizing the steel flow in the mold. Instability becomes more severe with larger throughput or a thinner mold. A static magnetic field is effective for reducing this instability. Furthermore, because an insufficient steel velocity causes entrapment of bubbles and inclusions on the solidified shell, optimization of the steel flow velocity by controlling the strength of the two domain magnetic fields is important. 2) Microstructure control of cast metal A static magnetic field suppresses the liquid flow, and the microstructure can be controlled by this flow control. In a Sn-Zn alloy casting test, the columnar grain ratio increased when a magnetic field stronger than 0.1 T was applied. These phenomena occurred because thermal convection was reduced by the magnetic brake, followed by less supercooling at the dendrite end. The equiaxed crystal size increases with a magnetic field. Since the magnetic field in the early stage has a larger effect, nuclear generation of equiaxed crystals is considered to be restrained by reducing the steel flow and the temperature gradient.
Insulation status detection on the high voltage bushing by FRA method (2012)

This paper mainly discusses the mechanism for FRA method on bushing insulation detection. It builds several RC models of the bushing instruction in MATLAB, as well as does some simulation work to observe the change of the FRA curve with different parameters. It also takes the influence of the valve wire into consider and get some useful conclusions. Simulation results show that the obvious indentation in the FRA curve will appear when the bushing has some insulation defects. The sum and change state of the indentation in FRA curve is related to the degree and relaxation polarization of the insulation defects of the bushing. It is found that the simulation and on-spot detection curves have tallies with each other, which verifies the feasibility of FRA method in this field.
The 'Exploration Atmosphere' Flight Study on ISS: Assessment of lmmunity, Oxidative Stress, Vision and Cognition (2016)

Spaceflight is documented to profoundly dysregulate the human immune system. This phenomenon presents in astronauts as altered peripheral leukocyte distribution, depressed T cell function, altered cytokine production profiles, and persistent reactivation of latent alpha and beta herpesviruses. NASA is now constructing vehicles for deep space exploration-class missions which, regardless of destination, would occur beyond low Earth orbit and may take years to complete. Persistent immune dysregulation spanning such missions may increase specific clinical risks for exploration crewmembers. An 'exploration atmosphere' consisting of 8.2 PSI and 34% oxygen has been proposed for sustained habitation. The purpose of the altered atmosphere is to greatly facilitate EVA activities, reducing 'prebreathe' and other required preparations. In various Terrestrial environments persistent hypobaric hypoxia has been demonstrated to negatively influence immune function and result in cardiovascular irregularities in otherwise healthy subjects. Above the already-dysregulated state of the immune system during flight, it is unknown if the proposed atmosphere will further negatively influence crews and possibly enhance crew clinical risk during exploration class deep space missions. The purpose of the flight study is to determine physiological adaptation to the exploration atmosphere during spaceflight. ISS crews will be exposed to the altered atmosphere onboard ISS. The exposure is currently planned to be via an overnight 'campout' in the US Airlock, at an operationally compatible (within the technical limits of the airlock module) atmosphere of 9.2 PSI and 29% oxygen. This atmosphere yields a lung and aveolar exposure nearly equivalent to the proposed exploration atmosphere. This study will assess various hematologic, immunologic (both innate + adaptive), oxidative stress and viral reactivation parameters. Consequently, vision and cogitative parameters will also be assessed simultaneously. Cellular functional measures will be obtained via on-orbit cell culture. Biological sampling or data acquisition will be performed pre-flight, in-flight before atmosphere exposure, in-flight during (near end of) the atmosphere exposure; and post-flight. All sampling, processing and sample preservation have been designed to work within anticipated operational constraints.
Ultra high-speed swept source OCT imaging of the anterior segment of human eye at 200 kHz with adjustable imaging range (2009)

We present an application of in vivo anterior segment imaging of the human eye with an ultrahigh speed swept source OCT instrument. For this purpose, a dedicated OCT system was designed and constructed. This instrument enables axial zooming by automatic reconfiguration of spectral sweep range; an enhanced imaging range mode enables imaging of the entire anterior segment while a high axial resolution mode provides detailed morphological information of the chamber angle and the cornea. The speed of 200,000 lines/s enables high sampling density in three-dimensional imaging of the entire cornea in 250 ms promising future applications of OCT for optical corneal topography, pachymetry and elevation maps. The results of a preliminary quantitative corneal analysis based on OCT data free form motion artifacts are presented. Additionally, a volumetric and real time reconstruction of dynamic processes, like pupillary reaction to light stimulus or blink-induced contact lens movements are demonstrated.
ChemInform Abstract: CYCLOOCT‐1‐EN‐5‐YNE. PREPARATION, SPECTROSCOPIC CHARACTERISTICS AND CHEMICAL REACTIVITY (1978)

Abstract Das nach Schema erhaltene En‐in (IV) ist bei Luftausschluß und ‐15°C beständig und liegt nach 1 H‐, 13 C‐NMR in zwei nichtplanaren Konformationen vor, die bei Raumtemp. im dynamischen Gleichgewicht stehen (Aktivierungsenergie der Konformationsumwandlung etwa 42 kJ/mol, Spannungsenergie des Moleküls etwa 75 i20 kJ/mol).
Identifying the High Radiosensitivity of the Lungs of C57L Mice in a Model of Total-Body Irradiation and Bone Marrow Transplantation (2010)

Pulmonary tissue is sensitive and often treatment-limiting in patients exposed to total-body irradiation (TBI) in preparation for hematopoietic stem cell transplantation. Many rodent strains, however, exhibit a relatively high resistance to radiation lung damage that often requires extra radiation doses to be delivered locally to the thorax to generate significant levels of pulmonary injury. The present study compared the effects of TBI and bone marrow transplantation (BMT) on two mouse strains that are known to differ in lung radiosensitivity after whole-thorax irradiation, namely the relatively resistant CBA mice and the sensitive C57L mice. Evaluation by survival, microcomputerized tomography (micro-CT), lung tissue weights and histopathology showed that the C57L mice responded with severe lethal radiation pneumonitis at 4 months after 12.5 Gy while CBA mice showed only minimal sublethal damage at this dose. C57L mice receiving 10 Gy TBI also had focal fibrotic lesions in the lungs out to 8 months. The manifestation of both pneumonitis and focal fibrosis in the lungs of C57L mice at relatively low radiation doses points to the merits of using this strain in further studies aimed at exploring and ameliorating the high susceptibility of the lung as encountered in clinical TBI.
Feasibility of inverting compaction-induced traveltime shifts for reservoir pressure (2012)

Pore-pressure variations inside producing reservoirs result in excess stress and strain that cause time shifts of reflected waves. Inversion of seismic data for pressure changes requires better understanding of the dependence of compaction-induced time shifts on reservoir pressure reduction. Here, we investigate pressure-dependent behavior of P-, S-, and PS-wave time shifts from reflectors located above and below a rectangular reservoir embedded in a homogeneous half-space. Our geomechanical modeling algorithm generates the excess stress/strain field and the stress-induced stiffness tensor as linear functions of reservoir pressure. Analysis of time shifts obtained from full-waveform synthetic data shows that they vary linearly with pressure for reflectors above the reservoir, but become nonlinear for reflections from the reservoir or deeper interfaces. Time-shift misfit curves computed with respect to noise-contaminated data from a reference reservoir for a wide range of pressure reductions display well-defined minima. Our results indicate that stable pressure estimation requires including multicomponent time shifts from reflectors below the reservoir and applying a nonlinear global inversion algorithm.
Nucleotide Sequence of theClostridium stercorarium xynBGene Encoding an Extremely Thermostable Xylanase, and Characterization of the Translated Product (1995)

The nucleotides of the xynB gene of Clostridium stercorarium F-9 were sequenced. The structural gene consists of an open reading frame of 1161 bp encoding a xylanase (XynB) in family F of 387 amino acids with a molecular weight of 44,377. The molecular weight of the enzyme purified from a recombinant Escherichia coli was around 41,000, smaller than the predicted value, on SDS-polyacrylamide gel electrophoresis due to the lack of 32 amino acids at the N-terminus. Intact XynB with a molecular weight of around 43,000 was immunologically detected in the total cell proteins of a recombinant E. coli and C. stercorarium F-9. The purified XynB was active toward xylan, carboxymethylcellulose, p-nitrophenyl-beta-D-xylopyranoside and p-nitrophenyl-beta-D-cellobioside. The pH optimum was 7.0 and it was quite stable over the pH range of 5 to 12 at 4 degrees C. This enzyme was optimally active at 80 degrees C and retained about 50% of the original activity even after incubation at 100 degrees C for 10 min.
A New Pyrroloquinazoline Alkaloid from Linaria vulgaris. (2002)

A new alkaloid, 1,2,3,9-tetrahydropyrrolo(2,1-b)quinazolin-1-carboxylic acid (1), together with eight known compounds, 7-hydroxy vasicine (2), benzyl alcohol beta-D-(2'-O-beta-xylopyranosyl)glucopyranoside (3), benzyl alcohol O-beta-D-glucopyranoside (4), benzyl alcohol O-beta-D-primveroside (5), 3,5-dimethyl-4-hydroxy benzaldehyde (6), gluco-syringic acid (7), syringin (8), and liriodendrin (9), were isolated from the plants of Linaria vulgaris. Their structures were established by spectroscopic methods.
A safe practical synthesis of difluorophosphonoacetic acid (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA safe practical synthesis of difluorophosphonoacetic acidDonald J. Burton, Lee G. Sprague, Donald J. Pietrzyk, and Steven H. EdelmuthCite this: J. Org. Chem. 1984, 49, 18, 3437–3438Publication Date (Print):September 1, 1984Publication History Published online1 May 2002Published inissue 1 September 1984https://pubs.acs.org/doi/10.1021/jo00192a056https://doi.org/10.1021/jo00192a056research-articleACS PublicationsRequest reuse permissionsArticle Views333Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Molecular Fingerprint Detection Using Portable Water‐Compatible Electronic Tunneling Spectroscopy Device (2020)

Abstract Real‐time and label‐free recognition of molecules is highly desired in numerous fields; however, most existing detection schemes require specific functionalization of the device suited for the molecule to be detected and is often complicated by nonselective adsorption. Current detection methodologies that deliver detailed molecular‐level information typically require elaborate analytical instrumentation to overcome these limitations, rendering those costly, not scalable, and nonportable techniques. Herein, a detection scheme is presented that rely on measurement of the tunneling currents through molecules under ambient conditions by employing a robust, scalable, portable, and water‐compatible device. High aspect ratio semiconductor–metal hybrid nanosystems, which feature a metal tip (Au) that functions as a nanoelectrode, are utilized to create self‐formed nanojunctions. Analyte molecules intercalate between the nanoscopic gold tip and a counter electrode, resulting in distinctive tunneling currents. Characteristic d I /d V fingerprint traces, unique to the density of states of the molecular species embedded in the liquid medium, are detectable. Resetting is demonstrated by desorption of adsorbed molecules by applying a reset voltage bias. This study paves the way toward low‐cost, on‐site, and real‐time information‐rich molecular detectors.
Variable Fidelity Differential-Algebraic Equation Model Correlation (1997)

ABSTRACT A formulation for selecting operator and control inputs to a high fidelity dynamics model, governed by differential-algebraic equations, is presented to minimize deviation in its response relative to that of a lower fidelity model that is also governed by differential-algebraic equations of motion. An adjoint variable method for computing sensitivity of the error measure defined is derived and implemented in a nonlinear programming formulation that is suitable for iterative minimization of the error functional. A numerical example using a multibody mechanism is presented to demonstrate effectiveness of the method and provide insights into means for effectively formulating problems of model correlation and strategies for their solution
Sensing properties of one-dimensional photonic crystals comprising zeolite and niobium pentoxide multilayered structure (2014)

International audience
Hypericin, Hypocrellin, and Model Compounds:  Steady-State and Time-Resolved Fluorescence Anisotropies (1998)

Steady-state and time-resolved fluorescence anisotropies of hypericin, hypocrellin, and five other analogues have been measured. The steady-state excitation anisotropies for each of these compounds has a broad minimum at ∼400 nm with a negative value. At the blue and red edges of the spectrum the value of the anisotropy is positive. Time-resolved fluorescence anisotropy measurements were performed for both hypericin and hypocrellin at excitation wavelengths of 300 and 570 nm. The limiting anisotropies are in excellent agreement with the corresponding steady-state values. These results are discussed in terms of the directions of the transition dipoles connecting the ground state to various excited states. The role of conformational isomers and tautomers in the ground and excited states is also considered.