gebhart/patrepeval huggingface dataset:
Effects of Retinoid -Glucuronides and N-Retinoyl Amines on the Differentiation of HL-60 Cells in Vitro (1987)

Retinoyl beta-glucuronide and retinyl beta-glucuronide, which are naturally occurring water-soluble metabolites of vitamin A, induce the granulocytic differentiation of HL-60 cells in vitro, as evidenced by an increased reduction of nitroblue tetrazolium. The relative effectiveness of various retinoids in differentiation is retinoic acid greater than retinoyl beta-glucuronide greater than retinyl beta-glucuronide. Under the selected assay conditions, retinol, hydroxyphenyl-retinamide, retinamide, and N-retinoyl-phenylalanine are essentially inactive in differentiation. At concentrations of retinoids from 10(-9) to 10(-5) M, cell viability was best with the retinoid beta-glucuronides and retinamide, less with retinoic acid and retinol, and poorest with the N-retinoyl aromatic amines. Cellular growth was depressed only slightly by retinyl beta-glucuronide and retinamide, but to a greater degree by the other derivatives. Retinoyl beta-glucuronide was hydrolyzed in part to retinoic acid, whereas retinyl beta-glucuronide was cleaved to retinol, if at all, at a very slow rate. Under the selected assay conditions, retinoic acid and the retinoid beta-glucuronides primarily induce the differentiation of HL-60 cells, whereas the N-retinoyl aromatic amines show cytotoxicity.
Effect of Fluvastatin Slow-Release on Low Density Lipoprotein (LDL) Subfractions in Patients with Type 2 Diabetes Mellitus: Baseline LDL Profile Determines Specific Mode of Action (2002)

The objective of this study was to determine the effect of slow-release (XL) fluvastatin on low density lipoprotein (LDL) subfractions in type 2 diabetes. A multicenter, double-blind, randomized, parallel-group comparison of fluvastatin XL 80 mg (n = 42) and placebo (n = 47), each given once-daily for 8 wk, in 89 patients with type 2 diabetes (HbA1c: 7.2 +/- 1.0%, LDL cholesterol (LDL-C): 3.4 +/- 0.7 mmol/liter, high density lipoprotein cholesterol: 1.1 +/- 0.3 mmol/liter, and triglycerides (TG): 2.4 +/- 1.4 mmol/liter). At baseline and on treatment, plasma lipoproteins were isolated and quantified. Eight weeks of fluvastatin treatment decreased total cholesterol (-23.0%, P < 0.001), LDL-C (-29%, P < 0.001) and TG (-18%, P < 0.001), compared with placebo. At baseline, there was a preponderance of dense LDL (dLDL) (apolipoprotein B in LDL-5 plus LDL-6 > 25 mg/dl) in 79% of patients, among whom fluvastatin decreased all LDL subfractions, reductions in dLDL being greatest (-28%, P = 0.001; cholesterol in dLDL -29%). In patients with low baseline dLDL (apolipoprotein B in LDL-5 plus LDL-6 </= 25 mg/dl), but a preponderance of buoyant LDL (LDL-1 through LDL-3), fluvastatin significantly decreased only these subfractions. Fluvastatin 80 mg XL, once daily, decreased total cholesterol and total LDL-C. In patients with atherogenic dLDL, absolute changes of dLDL were most pronounced, emphasizing the value of fluvastatin treatment in type 2 diabetes. The antiatherogenic potential of fluvastatin in type 2 diabetes may thus be greater than that expected from its effects on LDL-C and TG alone.
Adaptive accommodation of failures in second-order flight control actuators with measurable rates (2005)

In this paper effective failure detection, identification and reconfiguration (FDIR) algorithms are developed for a class of linearized aircraft models and second-order actuator dynamics. Assuming that the actuator dynamics are fast, a baseline controller is designed and, using the singular perturbation arguments, shown to achieve the control objective. Typical failures in flight control actuators described by first and second order dynamics are considered next, and the FDI algorithms are derived for the latter case. This is followed by the design of a corresponding adaptive reconfigurable controller, and the main theorem is proved stating that all the signals in the system are bounded and that the tracking error converges to zero asymptotically despite multiple simultaneous actuator failures. The properties of the proposed FDIR algorithms are evaluated through numerical simulations of the F-18 aircraft.
Supplementary Figures 1 - 4 from Analysis of DNA Methylation in Bowel Lavage Fluid for Detection of Colorectal Cancer (2023)

&lt;p&gt;Supplementary Figure S1 Receiver operating characteristic curve analysis of the respective marker genes. Supplementary Figure S2 Ages of CRC patients (upper) and non-CRC individuals (lower) with the indicated M-scores. Each dot represents a single individual. Supplementary Figure S3 Comparison of the methylation results in paired BLF and biopsy specimens from primary tumors. The M-score and the Ct values of the endogenous control Alu repetitive element are indicated on the top. The methylation status of the three marker genes in the BLF and biopsy specimens is shown below. Supplementary Figure S4 CTC and colonoscopic views of the CRC of case 5 in Table 6 are shown. The polypoid adenoma portion is indicated by the red arrow and the flat adenocarcinoma portion is indicated by the yellow arrow.&lt;/p&gt;
Maximum-likelihood decoding in decode-and-forward based MIMO cooperative communication systems (2011)

We derive a maximum-likelihood (ML) decoder for a multiple antenna based decode-and-forward (DF) cooperative system utilizing an arbitrary complex-valued M-ary constellation. A sub-optimal piece-wise linear (PL) decoder is also derived, which works close to the ML decoder with significant reduction in decoding complexity. The proposed ML and PL decoders work for arbitrary complex-valued M-ary constellations with knowledge of the channel statistics of the source-relay links in the destination contrary to existing decoder of multi-antenna DF based systems which needs to know the exact source-relay channel coefficient. The proposed decoders outperform an amplify-and-forward protocol based multi-antenna cooperative system. We also derive the analytical symbol error rate (SER) of the PL decoder with multiple relays, M-PSK constellation, and asymptotically high signal-to-noise ratio (SNR) of the source-relay links.
Evaluation of a fiberoptic intracranial pressure monitor (1990)

The fiberoptic device is a relatively new type of intracranial pressure (ICP) monitor which appears to offer certain advantages over conventional monitoring systems, particularly its ability to measure brain parenchymal pressures. This study was undertaken to analyze the accuracy and drift characteristics of the fiberoptic device and to compare pressures in the subdural, intraparenchymal, and intraventricular compartments. The device was accurate to +/- 3 mm Hg over a 0- to 30-mm Hg range in vitro. The maximum daily drift was +/- 2.5 mm Hg, with an average daily drift of +/- 0.6 mm Hg and an average drift over a 5-day period of +/- 2.1 mm Hg. In vivo, the pressures and waveform characteristics obtained with the fiberoptic device and with a strain-gauge transducer connected to a ventriculostomy were very similar. Alterations in ICP were induced by various therapeutic and pathological manipulations, and the pressures in the three intracranial compartments were compared. Changes in ICP appeared to be reflected simultaneously and equally in all three compartments. Furthermore, changes in ICP secondary to a unilateral mass lesion were identical in both supratentorial parenchymal compartments when measured simultaneously. It is concluded that the fiberoptic device is an accurate and reliable system for ICP monitoring; the pressures recorded in the subdural, intraparenchymal, and intraventricular compartments paralleled each other in all of the physiological and pathological states tested. Although the drift associated with this device is less than that reported for previously available systems, its maximal cumulative drift over a 5-day period of +/- 6 mm Hg is significant. Since the fiberoptic device cannot be recalibrated in situ, it is suggested that the device be replaced if monitoring is to be continued for periods longer than 5 days.
Amorphous Cu2-δO as Passivation Layer for Ultra Long Stability of Copper Oxide Nanowires in Photoelectrochemical Environments (2018)

Core-shell CuO-Cu_2O nanowires with a surface amorphous Cu2-δO layer leads to high stability photocathodes for use in photoelectrochemical splitting of water. The nanowires are synthesized via carbothermal reduction of CuO nanowires at 300°C during which a 2–3 nm conformal and amorphous Cu_(2-δ)O layer is formed on the nanowire surface. This Cu_(2-δ)O layer enhances photocurrent and improves photocorrosion stability of the nanowires. While catalyst-free, pristine CuO nanowires show a photocurrent density is 0.50 mA/cm^2 and a stability of 53% after 3.4 hours of testing at −0.50 V under AM1.5 G conditions; the catalyst-free, carbothermally reduced nanowires achieve a photocurrent density of 0.75 mA/cm^2 and an improved stability of 96% under identical test conditions. The mechanism of enhanced photocurrent and its stability is discussed in the context of extensive pre and post test nanowire characterization.
dsPIC-based advanced data acquisition system for Monitoring, Control and Security Applications (2015)

This paper reports on design and implementation of data acquisition system based on dsPIC Microcontroller for Monitoring, Control and Security Application. Data acquisition is fundamental stage in any DSP, monitoring and digital control and security system. The efficiency and effectiveness of the system is defined by the quality of acquired data, which in turn depends on the characteristics of data acquisition system. There are two types of data acquisition; (a) digital (b) analog data acquisition, having different characteristics and system requirements. Microchip's dsPIC provides various on-chip integrated modules which enable efficient data acquisition such as 10/12-bit Analog to Digital Convertor (ADC) with up to 1Msps (Million samples per second) sampling rate, simultaneous sampling and various trigger mechanisms, Timers, Input Capture (IC), External (hardware) and Internal (software) Interrupt and processing capability up to 30 MIPS (Million Instructions Per Second). A system is developed for data acquisition of 16 analog signals with 10/12-bit resolution, simultaneous sampling of 4 signals, fixed and variable sampling rate, on chip storage and real-time signal processing capabilities. The system also supports for data acquisition of digital signals with time resolution of up to 33.33nsec and signal parameters like frequency, time period, pulse width, duty cycle, and delay & time difference between two signals. It can be customized according to the system requirements and provides advanced data acquisition capabilities to the low cost monitoring, control or security system.
Controlling the Galvanic Corrosion of Copper during Chemical Mechanical Planarization of Ruthenium Barrier Films (2011)

A specific challenge for integrating Ru as barrier in Cu interconnect structures is the galvanic corrosion of Cu that occurs during chemical mechanical planarization (CMP). The present work reports an electrochemical approach to mitigate this problem through judicious engineering of CMP dispersions using benzotriazole and ascorbic acid as selective anodic and cathodic corrosion inhibitors for Cu and Ru, respectively. The experimental background slurry employs KIO4 at pH = 9, where the removal rates of both Ru and Cu are reasonable and the formation of RuO4 is avoided.
Novel hybrid transition metal complexes of diaquabis(acetylacetonato‐κ2o,o′)[nickel(II)/zinc (II)] as solid metal–organic precursors: Synthesis, properties and magnetic response (2017)

A series of hybrid hetero bimetallic metal–organic frameworks, as solid metal–organic precursors, have been prepared via a conventional hydrothermal method. Herein, we report a facile approach for the synthesis of novel crystalline organic–inorganic hybrid compounds of diaquabis(acetylacetonato)[nickel(II)/zinc(II)] in the presence of varying mole ratios of Ni(II)/Zn(II) mixed metal ions. C 10 H 18 O 6 Ni 0 . 7 Zn 0 . 3 (N 0 . 7 Z 0 . 3 AA.2H 2 O) as an instance of the series has been investigated through detailed characterization. The crystal is composed of N 0 . 7 Z 0 . 3 AA units and two coordinated water molecules to form a monoclinic structure with space group P21/c. All the solid‐state structures have the metals in octahedral environments forming six‐membered chelate rings. The unit cell dimensions were obtained using single‐crystal X‐ray diffraction. Thermogravimetric analysis reveals that the hybrid compounds can be considered as suitable precursors for the synthesis of oxides via metal–organic chemical vapour deposition. At room temperature, all crystals clearly exhibit paramagnetic behaviour. Besides varying molar ratios of hybrid, the transition point of magnetic behaviour occurs at Ni critical concentration of around 10% in the hybrid. In addition, the magnetic susceptibility increases with increasing Ni content in the compounds.
A study on multilingual acoustic modeling for large vocabulary ASR (2009)

We study key issues related to multilingual acoustic modeling for automatic speech recognition (ASR) through a series of large-scale ASR experiments. Our study explores shared structures embedded in a large collection of speech data spanning over a number of spoken languages in order to establish a common set of universal phone models that can be used for large vocabulary ASR of all the languages seen or unseen during training. Language-universal and language-adaptive models are compared with language-specific models, and the comparison results show that in many cases it is possible to build general-purpose language-universal and language-adaptive acoustic models that outperform language-specific ones if the set of shared units, the structure of shared states, and the shared acoustic-phonetic properties among different languages can be properly utilized. Specifically, our results demonstrate that when the context coverage is poor in language-specific training, we can use one tenth of the adaptation data to achieve equivalent performance in cross-lingual speech recognition.
Data quality evaluation for observational multiple sclerosis registries (2016)

The implemented scores enable objective evaluation of the quality of observational MS data, with an impact on the design of future analyses.
DYRK1B variant linked to autosomal dominant metabolic syndrome (2014)

A form of the metabolic syndrome associated with mutations in DYRK1B Keramati et al. (2014) New England Journal of Medicine 370: 1909–1919.
Synthesis and properties of polyurethane modified with aminoethylaminopropyl poly(dimethyl siloxane) (1999)

A series of polyurethanes with different siloxane contents were synthesized, which were based on 4,4′-methylene diphenyl diisocyanate (MDI), poly(tetramethylene oxide) (PTMO), aminoethylaminopropyl poly(dimethyl siloxane) (AEAPS), and butanediol (BD). The chemical compositions, structures, and bulk and surface properties were investigated using an infrared surface quantitative analysis technique (FTIR-ATR), surface contact angle, electron spectroscopy for chemical analysis (ESCA), stress–strain analysis, and dynamic mechanical thermal analysis (DMTA). It was shown that siloxane concentration on the surface region of the elastormers was higher than that in the bulk for a resulting surface enrichment of the siloxane, and the tensile properties of these elastomers were not changed significantly with the AEAPS modification. © 1999 John Wiley & Sons, Inc. J Appl Polym Sci 74: 2552–2558, 1999
Bicitropeptide, antacid and placebo in gastric and duodenal ulceration. A two-centre, double-blind, comparative endoscopic study. (1979)

A bismuth-peptide complex (BCP Compound), an antacid (Maalox) and corresponding placebos were studied in a 6-week comparative double-blind trial of treatment in 106 randomized ambulant patients with endoscopically proven duodenal and gastric ulcers. Patients were examined after 1, 3 and 6 weeks' treatment and results assessed separately for duodenal and gastric ulcers on endoscopic evidence at weeks 3 and 6 respectively. Bicitropeptide was significantly better than antacid and placebo at 3 and 6 weeks for treatment of both duodenal and gastric ulcers. In the bicitropeptide group 100% of the patients in the duodenal ulcer group and 95,2% in the gastric ulcer group responded to treatment (improved or healed). No haematological or biochemical changes were noted and no adverse effects were recorded.
18 F-PI2620 Tau-PET in Progressive Supranuclear Palsy – A Multi-Center Evaluation (2020)

Ziel/Aim Progressive supranuclear palsy (PSP) is a 4-repeat (4R) tauopathy and region-specific tau deposits establish the neuropathological diagnosis of “definite PSP” post mortem. Future interventional trials against tau in PSP would strongly benefit from biomarkers to validate the specific presence of the target before therapy initiation. The novel second generation tau-PET ligand 18F-PI2620 proved absent off-target binding to monoamine oxidases and high affinity to 3/4R tau in Alzheimer’s disease (AD). The aim of this multicenter-evaluation was to investigate 18F-PI2620 in patients with suspected 4R tau pathology in clinically diagnosed PSP.
Myringosclerosis and Otosclerosis - their effects in the stapes footplate (2012)

The ear connects people to the outside world and contributes to sense of balance. However, a number of disorders can interrupt this perfect state, resulting in hearing impairment. Middle ear pathology, like myringosclerosis or otosclerosis is frequently seen and its early treatment is crucial to prevent others worst situations. The myringosclerosis is a formation of dense connective tissue in the eardrum, not usually associated with hearing loss. Otosclerosis is an abnormal growth of bone near the stapes and can result in conductive and/or sensorineural hearing loss [4]. In this work, a 3D solid model of tympano ossicular chain was built [2] with the integration of an improved membrane model [1], based on the finite element method, using the ABAQUS software. The ossicles (malleus, incus and stapes) were considered isotropic and the eardrum orthotropic. The material properties were obtained by literature [5]. The ligaments that connect the ossicles to the cavity tympanic walls have a hyperelastic behavior being a Yeoh model applied. The strain-energy function, for the Yeoh model can be written as [3]:
Chains of Magnetosomes Extracted from AMB-1 Magnetotactic Bacteria for Application in Alternative Magnetic Field Cancer Therapy (2011)

Chains of magnetosomes extracted from AMB-1 magnetotactic bacteria are shown to be highly efficient for cancer therapy when they are exposed to an alternative magnetic field. When a suspension containing MDA-MB-231 breast cancer cells was incubated in the presence of various amounts of extracted chains of magnetosomes, the viability of these cells remained high in the absence of an alternative magnetic field. By contrast, when this suspension was exposed to an alternative magnetic field of frequency 183 kHz and field strengths of 20, 40, or 60 mT, up to 100% of these cells were destroyed. The antitumoral activity of the extracted chains of magnetosomes is demonstrated further by showing that they can be used to fully eradicate a tumor xenografted under the skin of a mouse. For that, a suspension containing ∼1 mg of extracted chains of magnetosomes was administered within the tumor and the mouse was exposed to three heat cycles of 20 min, during which the tumor temperature was raised to ∼43 °C. We also demonstrate the higher efficiency of the extracted chains of magnetosomes compared with various other materials, i.e., whole inactive magnetotactic bacteria, individual magnetosomes not organized in chains, and two different types of chemically synthesized superparamagnetic iron oxide nanoparticles currently tested for alternative magnetic field cancer therapy. The higher efficiency of the extracted chains of magnetosomes compared with that of the other nanoparticles is attributed to three factors: (i) a specific absorption rate higher for the magnetosomes than for the chemically synthesized superparamagnetic iron oxide nanoparticles, (ii) a more uniform heating for the chains of magnetosomes than for the individual magnetosomes and (iii) the ability of the chains of magnetosomes to penetrate within the cancer cells or bind at the cell membrane following the application of the alternative magnetic field, which enables efficient cell destruction. Biodistribution studies revealed that extracted chains of magnetosomes administered directly within xenografted breast tumors progressively left the tumors during the 14 days following their administration and were then eliminated in large proportion in the feces.
Clinical Features and the Diagnostic Value of Component Allergen-Specific IgE in Hymenoptera Venom Allergy (2012)

Stings by yellow jackets and male sex may be risk factors for hymenoptera venom allergy in Korea. Vespidae component-specific IgE, but not Apidae component-specific IgE, had diagnostic and monitoring value in hymenoptera venom allergy comparable to that of conventional hymenoptera venom extract-specific IgE.
Improved synthesis of nido-tricarbonylmanganahexaborane (2,2,2-(CO)3-2-MnB5H10) via heterogeneous catalysis. Synthesis and characterization of the new rhenahexaborane 2,2,2-(CO)3-2-ReB5H10 (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTImproved synthesis of nido-tricarbonylmanganahexaborane (2,2,2-(CO)3-2-MnB5H10) via heterogeneous catalysis. Synthesis and characterization of the new rhenahexaborane 2,2,2-(CO)3-2-ReB5H10Darrell E. Coons and Donald F. GainesCite this: Inorg. Chem. 1985, 24, 23, 3774–3777Publication Date (Print):November 1, 1985Publication History Published online1 May 2002Published inissue 1 November 1985https://pubs.acs.org/doi/10.1021/ic00217a016https://doi.org/10.1021/ic00217a016research-articleACS PublicationsRequest reuse permissionsArticle Views48Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts