gebhart/patrepeval huggingface dataset:
Expansion and Enrichment of Gamma-Delta (&#947;&#948;) T Cells from Apheresed Human Product (2021)

Although Vγ9Vδ2 T cells are a minor subset of T lymphocytes, this population is sought after for its ability to recognize antigens in a major histocompatibility complex (MHC)-independent manner and develop strong cytolytic effector function that makes it an ideal candidate for cancer immunotherapy. Due to the low frequency of Gamma-Delta (γδ) T cells in the peripheral blood, we developed an effective protocol to greatly expand a highly pure γδ T cells drug product for first-in-human use of allogeneic γδ T cells in patients with acute myeloid leukemia (AML). Using healthy donor apheresis as an allogenic cell source, the lymphocytes are isolated using a validated device for a counterflow centrifugation method of separating cells by size and density. The lymphocyte-rich fraction is utilized, and the γδ T cells are preferentially activated with zoledronic acid (FDA-approved) and interleukin (IL)-2 for 7 days. Following the preferential expansion of γδ T cells, a clinical-grade magnetic cell-separation device and TCRαβ beads are used to deplete contaminating T-cell receptor (TCR)αβ T cells. The highly enriched γδ T cells then undergo a second expansion using engineered artificial antigen-presenting cells (aAPCs) derived from K562 cells-genetically engineered to express single-chain variable fragment (scFv) for CD3 and CD28, 41BBL (CD137L) and IL15-RA-together with zoledronic acid and IL-2. Seeding all day-7 enriched γδ T cells in co-culture with the aAPCs facilitates the manufacture of highly pure γδ T cells with an average fold expansion of >229,000-fold from healthy donor blood.
Prognostically relevant natural killer cell-mediated immunoediting in acute myeloid leukemia (2013)

Meeting abstracts Natural Killer (NK) cells contribute to the control of cancer through immunosurveillance and may influence phenotypic sculpting of cancer through immunoediting. NK cells may also contribute to the control of hematological malignancies such as acute myeloid leukemia (AML) following
Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits formation of osteolytic lesions in vivo (2005)

Proc Amer Assoc Cancer Res, Volume 46, 2005

2912 

Runx transcription factors comprise a family of proteins that are essential for organogenesis. The Runx transcription factors function as scaffolds for interaction with a variety of coregulatory proteins. A unique nuclear matrix targeting signal (NMTS) in the C-terminus directs these factors to their specific subnuclear domains. At these sites they interact with coregulatory proteins and target genes. We have previously shown that Runx2 is highly expressed in metastatic breast cancer cells, but that inhibition of Runx2 can prevent production of osteolytic lesions in bone (Barnes et al., Cancer Res., 2004, 64:4506). Here we show that proper Runx2 subnuclear targeting is required for osteolysis. We have identified point mutations of the Runx2 NMTS sequence that impair its targeting to nuclear matrix sites. MDA-MB-231 or targeting deficient mutant Runx2 expressing stable cells were injected into the intramedullary region of the tibia of 4-6 week old SCID mice. Formation of osteolytic lesions in bones was assessed by radiography. The mutation blocks the invasive and osteolytic properties of MDA-MB-231 breast cancer cells in vivo . Cell lines expressing this Runx2 mutant protein inhibit the osteogenic properties of bone marrow stromal cells in co-culture assays and production of cytokines that promote the osteolytic lesions. The mutant breast cancer cells also exhibit reduced invasiveness in vitro and do not express genes involved in invasion and angiogenesis (VEGF, MMP13). Our findings suggest that fidelity of Runx2 intranuclear organization is necessary for expression of target genes that mediate the osteolytic activity of metastatic breast cancer cells.
Simultaneous estimation of speed and rotor resistance of field oriented induction motor without rotational transducers (2002)

Several field oriented induction motor drive methods without rotational transducers have been proposed. These methods have a disadvantage that the rotor resistance variation causes the estimation error of the motor speed. Therefore, simultaneous estimation of the motor speed and the rotor resistance is required. This paper presents a method of estimating simultaneously the motor speed and the rotor resistance of an induction motor by superimposing AC components on the field current command.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Microstructure-Based Stress Modeling of Tin Whisker Growth (2006)

A 3-D finite element method (FEM) model considering the elasticity anisotropy, thermal expansion anisotropy, and plasticity of beta-Sn is established. The Voronoi diagrams are used to generate the geometric patterns of grains of the Sn coating on Cu leadframes. The crystal orientations are assigned to the Sn grains in the model using the X-ray diffraction (XRD) measurement data of the samples. The model is applied to the Sn-plated package leads under thermal cycling tests. The strain energy density (SED) is calculated for each grain. It is observed that the samples with higher calculated SED are more likely to have longer Sn whiskers and higher whisker density. The FEM model, combined with the XRD measurement of the Sn finish, can be used as an effective indicator of the Sn whisker propensity. This may expedite the qualification process significantly
Surface Integrity and Residual Stresses Analysis by Strain Gages after Hard Turning Process of Case Hardened Steel AISI 8620 (2009)

This work aims an analysis on the functional surface integrity resulting from turning mechanical components manufactured from case hardened steel AISI 8620 with 1 millimeter average layer depth and hardness of 58-62HRC. A cBN tool with PVD coat and Wiper geometry-edge was used for continuous turning of hardened steel, the cutting conditions (Vc [m/min] and f in [mm/rev]) used were concerned to reflect large running production of mechanical components.
Research on key technology of next generation video coding standard (2017)

991012554965003412 HKUST Electronic Theses Research on key technology of next generation video coding standard by Chen Chen thesis 2017 xiv, 123 pages : illustrations ; 30 cm The Joint Collaborative Team on Video Coding (JCT-VC) has recently accomplished a new…Read more ›
The changing epidemiology of type 1 diabetes: why is it going through the roof? (2010)

The incidence of type 1 diabetes is increasing and this may double the burden of disease in our youngest by 2020. The recent increase in incidence is mostly happening in the very young and those with moderate genetic susceptibility. Many environmental factors have been implicated, but no major determinants have been clearly identified, and the mechanisms of involvement remain elusive. This review summarizes current research efforts directed at understanding the possible reasons for this increase, including the role of viruses, gut microbiota, early life feeding patterns, perinatal factors and childhood growth patterns. It also provides a road map for future research directions.
Effect of Superpave Gyratory Compactor Type on Compacted Hot-Mix Asphalt Density (2001)

The SUperior PERforming Asphalt PAVEments (Superpave) gyratory compactor was developed as a tool in the Superpave mix design system to better simulate the field compaction of hot-mix asphalts. All Superpave gyratory compactors are designed to meet the specification criteria found in AASHTO TP4. At the present time, AASHTO TP4 does not contain a precision statement. Furthermore, many agencies have reported differences in the bulk specific gravity of compacted samples from different Superpave gyratory compactors, which have been properly calibrated. Data are presented and analyzed from three gyratory compactor proficiency sample testing programs, from field project Superpave gyratory compaction comparisons, and from mix design and quality control and assurance results from a state department of transportation. The data were then analyzed to determine the statistical (precision) and potential project implications that result from the observed differences. The results indicate that the precision of the Superpave gyratory compactor is better than the mechanical Marshall hammer. However, there were significant differences between the bulk specific gravity of mixes compacted in different gyratory compactors. These differences could potentially lead to discrepancies during the mix design verification and quality control and assurance testing of a given mix.
Effect of Pore Fluid Type on Perforation Damage and Flow Characteristics (2001)

Abstract This paper compares the results of two perforation tests performed to investigate porosity and permeability damage due to perforating in gas-saturated versus liquid-saturated conditions. We used a method combining transient analysis and X-ray computed tomography (CT) map variations in permeability and porosity around the perforation tunnel. Experiments were conducted on 10-cm (4-in.)-diameter Berea Sandstone cores saturated with either low-viscosity silicone oil or nitrogen gas. Perforation flow tests were performed according to API RP43 procedures using conventional 6-gram HMX explosive charges, 6.9-Mpa (1000-psi) effective stress, and 5.2-Mpa (750-psi) underbalance. After flushing the perforations to remove explosion gases and loose debris, higher viscosity silicone oil was injected into the tunnels and movement of the front in the core was tracked using X-ray CT to measure the front velocity. Radial permeability was determined by relating differential pressure, front position and velocity. Porosity near the perforations was measured by comparing images taken when the sample was saturated with the two different fluids. Analysis of the images and the data show that, for the specific charge and test conditions used, the type of fluid saturating the rock results in significantly different perforation geometries and damage under the same operating conditions. In the gas-saturated core, we obtained a shorter total penetration depth and a tunnel largely plugged with charge and rock debris. A zone of compacted rock, about 6 mm thick and with 6–8% less porosity than the average rock, surrounded the perforation tunnel. Near the entrance hole, the compaction was more severe when compared to other locations along the tunnel. The liquid-saturated core had a clean tunnel with a larger diameter and deeper penetration than the gas-saturated core. The liquid-saturated rock had no compacted zone. Permeability damage extended approximately 1.5 cm from the center of the perforation in the liquid-saturated core. The thickness of the damaged zone was a little higher in gas-saturated case when compared to liquid-saturated one.
Three-dimensional imaging of hidden objects using positron emission backscatter (2024)

Positron emission backscatter imaging is a technique for interrogation and three-dimensional (3-D) reconstruction of hidden objects when we only have access to the objects from one side. Using time-of-flight differences in detected direct and backscattered positron-emitted photons, we construct 3-D images of target objects. Recently at Los Alamos National Laboratory, a fully three-dimensional imaging system has been built and the experimental results are discussed in this paper. Quantitative analysis of images reconstructed in both two- and three-dimensions are also presented.
Contribution à l'automatisation du déploiement d'applications sur des grilles de calcul (2005)

Le deploiement d'applications de calcul scientifique sur des grilles informatiques est un probleme difficile, du fait de la complexite des applications et de l'heterogeneite des grilles. Dans le but de masquer ces difficultes, cette these propose une architecture qui automatise le processus de deploiement d'applications comprenant plusieurs programmes qui communiquent entre eux sur des grilles de calcul. Nous proposons egalement un modele de description de la topologie reseau complexe des grilles, ainsi que des modeles de description specifique d'applications paralleles et d'applications mixtes (a la fois paralleles et distribuees). Nous introduisons la notion de description generique d'applications, qui permet a un unique planificateur de deploiement de selectionner les ressources d'execution et de placer les constituants des applications. Ces contributions sont validees par la mise en oeuvre d'un outil de deploiement automatique.
Generic and Robust Localization of Multi-dimensional Root Causes (2019)

Operators of online software services periodically collect various measures with many attributes. When a measure becomes abnormal, indicating service problems such as reliability degrade, operators would like to rapidly and accurately localize the root cause attribute combinations within a huge multi-dimensional search space. Unfortunately, previous approaches are not generic or robust in that they all suffer from impractical root cause assumptions, handling only directly collected measures but not derived ones, handling only anomalies with signicant magnitudes but not those insignicant but important ones, requiring manual parameter ne-tuning, or being too slow. This paper proposes a generic and robust multi-dimensional root cause localization approach, Squeeze, that overcomes all above limitations, the first in the literature. Through our novel bottom-up then top-down searching strategy and the techniques based on our proposed generalized ripple effect and generalized potential score, Squeeze is able to reach a good trade off between search speed and accuracy in a generic and robust manner. Case studies in several banks and an Internet company show that Squeeze can localize root causes much more rapidly and accurately than the traditional manual analysis. Furthermore, our extensive experiments on semi-synthetic datasets show that the F1-score of Squeeze outperforms previous approaches by 0.4 on average, while its localization time is only about 10 seconds.
A Robust One‐Compartment Fuel Cell with a Polynuclear Cyanide Complex as a Cathode for Utilizing H2O2 as a Sustainable Fuel at Ambient Conditions (2013)

A robust one-compartment H2O2 fuel cell, which operates without membranes at room temperature, has been constructed by using a series of polynuclear cyanide complexes that contain Fe, Co, Mn, and Cr as cathodes, in sharp contrast to conventional H2 and MeOH fuel cells, which require membranes and high temperatures. A high open-circuit potential of 0.68 V was achieved by using Fe3[{Co(III)(CN)6}2] on a carbon cloth as the cathode and a Ni mesh as the anode of a H2O2 fuel cell by using an aqueous solution of H2O2 (0.30 M, pH 3) with a maximum power density of 0.45 mW cm(-2). The open-circuit potential and maximum power density of the H2O2 fuel cell were further increased to 0.78 V and 1.2 mW cm(-2), respectively, by operation under these conditions at pH 1. No catalytic activity of Co3[{Co(III)(CN)6}2] and Co3[{Fe(III)(CN)6}2] towards H2O2 reduction suggests that the N-bound Fe ions are active species for H2O2 reduction. H2O2 fuel cells that used Fe3[{Mn(III)(CN)6}2] and Fe3[{Cr(III)(CN)6}2] as the cathode exhibited lower performance compared with that using Fe3[{Co(III)(CN)6}2] as a cathode, because ligand isomerization of Fe3[{M(III)(CN)6}2] into (FeM2)[{Fe(II)(CN)6}2] (M = Cr or Mn) occurred to form inactive Fe-C bonds under ambient conditions, whereas no ligand isomerization of Fe3[{Co(III)(CN)6}2] occurred under the same reaction conditions. The importance of stable Fe(2+)-N bonds was further indicated by the high performance of the H2O2 fuel cells with Fe3[{Ir(III)(CN)6}2] and Fe3[{Rh(III)(CN)6}2], which also contained stable Fe(2+)-N bonds. The stable Fe(2+)-N bonds in Fe3[{Co(III)(CN)6}2], which lead to high activity for the electrocatalytic reduction of H2O2, allow Fe3[{Co(III)(CN)6}2] to act as a superior cathode in one-compartment H2O2 fuel cells.
Prognostic Factors for Endometrial and Cervical Cancers of Uterus Treated With Immune-cell Therapy: A Retrospective Study (2020)

Survival benefit in uterine cancer patients could be potentially obtained by a combination of immune-cell therapy with other therapies.
Algebraic gossip on Arbitrary Networks (2009)

Consider a network of nodes where each node has a message to communicate to all other nodes. For this communication problem, we analyze a gossip based protocol where coded messages are exchanged. This problem was studied by Aoyama and Shah where a bound to the dissemination time based on the spectral properties of the underlying communication graph is provided. Our contribution is a uniform bound that holds for arbitrary networks.
Correlation Gating Quantifies Optical Properties of Dynamic Media in Transmission Mode (2018)

We apply correlation gating with interferometric near-infrared spectroscopy (iNIRS) to separate ballistic and scattered light transmitted through thick samples. By analyzing each component, we determine optical properties of a dynamic medium from one measurement set.
INTERNAL INSPECTION OF FAST REACTOR FUEL ELEMENTS (1959)

A proposed inspection program for fuel elements in the Dounreny Fast Reactor is discussed. Prototype apparatus designed to provide optical inspection of the bore of the inner tube is described. (A.C.) l6566 When the reactor is shut down, circulation of sodium through the reactor is by thermal convection. The result is that sodium at a relatively low temperature is brought into contact with piping that is still at a high temperature, thereby leading to excessive thermal stresses. These stresses were minimized by installing two eddy-current brakes to control flow in proportion to heat generation, resulting in constant temperature gradients. The operation of these eddy-current brakes is described. (A.C.)
Image artifacts resulting from gamma-ray tracking algorithms used with compton imagers (2005)

For Compton imaging it is necessary to determine the sequence of gamma-ray interactions in a single detector or array of detectors. This can be done by time-of-flight measurements if the interactions are sufficiently far apart. However, in small detectors the time between interactions can be too small to measure, and other means of gamma-ray sequencing must be used. In this work, several popular sequencing algorithms are reviewed for sequences with two observed events and three or more observed events in the detector. These algorithms can result in poor imaging resolution and introduce artifacts in the back projection images. The effects of gamma-ray tracking algorithms on Compton imaging are explored in the context of the 4/spl pi/ Compton imager built by the University of Michigan.
Improving ontology-based user profiles (2004)

Personalized Web browsing and search hope to provide Web information that matches a user&amp;apos;s personal interests and thus provide more effective and efficient information access. A key feature in developing successful personalized Web applications is to build user profiles that accurately represent a user&amp;apos;s interests. The main goal of this research is to investigate techniques that implicitly build ontology-based user profiles. We build the profiles without user interaction, automatically monitoring the user&amp;apos;s browsing habits. After building the initial profile from visited Web pages, we investigate techniques to improve the accuracy of the user profile. In particular, we focus on how quickly we can achieve profile stability, how to identify the most important concepts, the effect of depth in the concept-hierarchy on the importance of a concept, and how many levels from the hierarchy should be used to represent the user.
Multicenter Comparison of Machine Learning Methods and Conventional Regression for Predicting Clinical Deterioration on the Wards (2016)

In this multicenter study, we found that several machine learning methods more accurately predicted clinical deterioration than logistic regression. Use of detection algorithms derived from these techniques may result in improved identification of critically ill patients on the wards.
Report on Crude Fiber in Alimentary Pastes and in Air-Dried Baked Cereal Products (1931)

Journal Article Report on Crude Fiber in Alimentary Pastes and in Air-Dried Baked Cereal Products Get access R L Horst R L Horst Associate Referee U. S. Food and Drug Administration, New Orleans, La Search for other works by this author on: Oxford Academic Google Scholar Journal of Association of Official Agricultural Chemists, Volume 14, Issue 4, 15 November 1931, Pages 493–494, https://doi.org/10.1093/jaoac/14.4.493 Published: 21 February 2020
Percutaneous Nephrolithotomy in Patients with Urinary Tract Abnormalities (2014)

Patients with urinary tract abnormalities who undergo PCNL have a higher risk of residual stones at discharge and need for secondary procedures, but comparable complication rates, operative time, and hospital stay.
Hardware Trojan Attack in Embedded Memory (2021)

Static Random Access Memory (SRAM) is a core technology for building computing hardware, including cache memory, register files and field programmable gate array devices. Hence, SRAM reliability is essential to guarantee dependable computing. While significant research has been conducted to develop automated test algorithms for detecting manufacture-induced SRAM faults, they cannot ensure detection of faults deliberately implemented in the SRAM array by untrusted parties in the integrated circuit development flow. Indeed, such hardware Trojan attacks represent an emerging security threat. While a growing body of research addresses Trojan designs in logic circuits, little research has explored hardware Trojan attacks in embedded memory arrays [20]. In this article, we propose a new class of hardware Trojans targeting embedded SRAM arrays. The Trojans are designed to evade industry standard post-manufacturing tests while enabling attacks targeting various system hardware components during deployment. Transistor-level simulation results demonstrate minimal impact on SRAM power, performance, and stability while Trojans are not activated. We also prove the feasibility of Trojan insertion in foundries by showing the proposed layouts that preserve the SRAM cell footprint and incur zero silicon area overhead. Finally, we elaborate on several system-level attacks that can leverage these Trojans to compromise security and privacy.
BAG1L Enhances Trans-activation Function of the Vitamin D Receptor (2000)

The vitamin D receptor (VDR) is a member of the steroid/retinoid receptor superfamily of nuclear receptors that has potential tumor-suppressive functions. We show here that VDR interacts with and is regulated by BAG1L, a nuclear protein that binds heat shock 70-kDa (Hsp70) family molecular chaperones. Endogenous BAG1L can be co-immunoprecipitated with VDR from prostate cancer cells (ALVA31; LNCaP) in a ligand-dependent manner. BAG1L, but not shorter non-nuclear isoforms of this protein (BAG1; BAG1M/Rap46), markedly enhanced, in a ligand-dependent manner, the ability of VDR to trans-activate reporter gene plasmids containing a vitamin D response element in transient transfection assays. Mutant BAG1L lacking the C-terminal Hsc70-binding domain suppressed (in a concentration-dependent fashion) VDR-mediated trans-activation of vitamin D response element-containing reporter gene plasmids, without altering levels of VDR or endogenous BAG1L protein, suggesting that it operates as a trans-dominant inhibitor of BAG1L. Gene transfer-mediated elevations in BAG1L protein levels in a prostate cancer cell line (PC3), which is moderately responsive to VDR ligands, increased the ability of natural (1alpha,25(OH)(2) vitamin D(3)) and synthetic (1alpha, 25-dihydroxy-19-nor-22(E)-vitamin D(3)) VDR ligands to induce expression of the VDR target gene, p21(Waf1), and suppress DNA synthesis. Thus, BAG1L is a direct regulator of VDR, which enhances its trans-activation function and improves tumor cell responses to growth-suppressive VDR ligands.