gebhart/patrepeval huggingface dataset:
Modulation of tolerance by mutant heat shock transcription factors. (1999)

It ought to be possible to recruit normal cellular defenses to mitigate ischemia/reperfusion damage and to reduce toxicity of chemotherapeutic drugs. Stress-preconditioned cells acquire a tolerant state characterized by increased resistance to such insults. This state is widely believed to be mediated, partially, by heat shock proteins (Hsps). Indirect evidence suggests that stress-induced Hsp expression is controlled by heat shock transcription factor 1 (Hsf1), which factor may therefore represent a preferred target for therapeutic modulation of tolerance. In support, positively acting (Hsf1(+)) and negatively acting (Hsf1(-)) mutants of Hsf1 were identified. Inhibition of endogenous Hsf1 activity by Hsf1(-) prevents stress-induced Hsp synthesis and development of tolerance. Hsf1(+) drastically enhances expression of major Hsps in the absence of stress and induces tolerance against heat, simulated ischemia and toxicity by cyclophosphamide. Where compared, tolerance induced was slightly better than that produced by heat preconditioning. Thus, development of the tolerant state is dependent on increased levels of the cohort of Hsps induced by stress preconditioning, and Hsf1 can induce accumulation of a typical set of Hsps, which proteins are alone capable of providing tolerance at a similar level as heat preconditioning. These findings make Hsf1 a preferred target for pharmacological intervention to deliberately induce tolerance.
Ferromagnetic resonance by means of local near-field microwave microscopy (2006)

A frequency-and field-swept non-destructive local FMR technique with an external linearly polarized magnetic probe is presented. The main features of this technique are local characterization and mobility: a small area of any location on the magnetic medium can be probed. Samples of arbitrary shape and size can be measured with a spatial resolution and bandwidth that depend only on the probe "tip".Traditionally, ferromagnetic resonance (FMR) measurements are performed in microwave cavities at a fixed frequency and variable applied DC magnetic field.In order to measure ferromagnetic resonance in magnetic materials we have employed an improved near-field microwave probe that provides a high coupling between the sample (external to the probe) and the probe.
Mena/VASP and αII-Spectrin complexes regulate cytoplasmic actin networks in cardiomyocytes and protect from conduction abnormalities and dilated cardiomyopathy (2013)

Together, our data suggest that Mena, VASP, and αII-Spectrin assemble cardiac multi-protein complexes, which regulate cytoplasmic actin networks. Conversely, Mena/VASP deficiency results in disrupted β-actin assembly, Z- and intercalated disc malformation, and induces dilated cardiomyopathy and conduction abnormalities.
Liberated Viewers, Polarized Voters--The Implications of Increased Media Choice for Democratic Politics (2002)

Not everything about the Internet is new. Before Internet users could access vast amounts of political information with the click of a mouse, cable subscribers could flip between different 24-hour news channels with the push of a remote. Before Internet users could download music or order movie tickets online, cable viewers could pick between different music channels and hundreds of movies and entertainment shows everyday. In short, long before the Internet offered an alternative to mainstream media, cable television satisfied many niche interests.
Nuclear "Run-On" Transcription Assays (2003)

Nuclear “run-on” (or “run-off”) transcription assays have been used to obtain quantitative information about the relative rates of transcription of different genes in nuclei isolated from a particular tissue or organ. This information can then be used in analyzing the factors that control the expression of specific genes. These assays are complimentary to measurements of the levels of mRNA species present in particular tissues or organs by hybridization to specific nucleic acid probes (see Chapter 18 ). Hybridization assays give a measure of how much mRNA is present; this is termed a “steady-state” level, since it reflects the balance between mRNA synthesis and degradation (although, of course, the “steady-state” level itself can change with time), whereas transcription assays give a direct measure of the activity of genes.
Dysregulation of in vitro cytokine production by monocytes during sepsis. (1991)

The production by monocytes of interleukin-1 alpha (IL-1 alpha), interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF alpha) in intensive care unit (ICU) patients with sepsis syndrome (n = 23) or noninfectious shock (n = 6) is reported. Plasma cytokines, cell-associated cytokines within freshly isolated monocytes and LPS-induced in vitro cytokine production were assessed at admission and at regular intervals during ICU stay. TNF alpha and IL-6 were the most frequently detected circulating cytokines. Despite the fact that IL-1 alpha is the main cytokine found within monocytes upon in vitro activation of cells from healthy individuals, it was very rarely detected within freshly isolated monocytes from septic patients, and levels of cell-associated IL-1 beta were lower than those of TNF alpha. Cell-associated IL-1 beta and TNF alpha were not correlated with corresponding levels in plasma. Upon LPS stimulation, we observed a profound decrease of in vitro IL-1 alpha production by monocytes in all patients, and of IL-1 beta, IL-6, and TNF alpha in septic patients. This reduced LPS-induced production of cytokines was most pronounced in patients with gram-negative infections. Finally, monocytes from survival patients, but not from nonsurvival ones recovered their capacity to produce normal amounts of cytokines upon LPS stimulation. In conclusion, our data indicate an in vivo activation of circulating monocytes during sepsis as well as in noninfectious shock and suggest that complex regulatory mechanisms can downregulate the production of cytokines by monocytes during severe infections.
HIV-1-specific antibody responses during acute and chronic HIV-1 infection (2009)

The antibody isotypes and specificities elicited during HIV-1 infection can provide a window into deciphering the detrimental effects of HIV-1 on B cell and T cell responses. Additionally, further characterization of the virus inhibitory capabilities of anti-HIV-1 antibody isotypes can define the spectrum of potential protective HIV-1 antibodies that could be readily elicited by experimental vaccines and adjuvants.
Electrical stimulation of the trigeminal nerve improves olfaction in healthy individuals: A randomized, double-blind, sham-controlled trial (2022)

TNS is a safe, simple, noninvasive method for boosting olfaction. Future studies should investigate the use of TNS on smell function across different stimulation parameters, odorants, and patient populations.
Meta-Lens Doublet in the Visible Region (2017)

Recently, developments in meta-surfaces have allowed for the possibility of a fundamental shift in lens manufacturing-from the century-old grinding technology to nanofabrication-opening a way toward mass producible high-end meta-lenses. Inspired by early camera lenses and to overcome the aberrations of planar single-layered meta-lenses, we demonstrate a compact meta-lens doublet by patterning two metasurfaces on both sides of a substrate. This meta-lens doublet has a numerical aperture of 0.44, a focal length of 342.5 μm, and a field of view of 50° that enables diffraction-limited monochromatic imaging along the focal plane at a wavelength of 532 nm. The compact design has various imaging applications in microscopy, machine vision, and computer vision.
Time Scales for Charge Equilibration ofOq+(3≤q≤8)Ions during Surface-Channeling Interactions with Au(110) (1995)

We report on measurements of scattered projectile angular and charge state distributions for 3.75 keV/amu ${\mathrm{O}}^{q+}$ $(3\ensuremath{\le}q\ensuremath{\le}8)$ ions surface channeled along the $〈1\overline{1}0〉$ direction of a Au(110) single crystal target. Projectile trajectory calculations indicate that the projectiles spend less than 30 fs within 2 \AA{} of the topmost Au surface layer. Nevertheless, almost complete charge equilibration is observed in the scattered projectile charge state distributions. It is concluded that, already at the target interface, strong screening effects are present which make possible direct capture to the projectile L and M shells in relatively large impact parameter collisions.
3D Pose-by-Detection of Vehicles via Discriminatively Reduced Ensembles of Correlation Filters (2014)

Estimating the precise pose of a 3D model in an image is challenging; explicitly identifying correspondences is difficult, particularly at smaller scales and in the presence of occlusion. Exemplar classifiers have demonstrated the potential of detection-based approaches to problems where precision is required. In particular, correlation filters explicitly suppress classifier response caused by slight shifts in the bounding box. This property makes them ideal exemplar classifiers for viewpoint discrimination, as small translational shifts can often be confounded with small rotational shifts. However, exemplar based pose-by-detection is not scalable because, as the desired precision of viewpoint estimation increases, the number of exemplars needed increases as well. We present a training framework to reduce an ensemble of exemplar correlation filters for viewpoint estimation by directly optimizing a discriminative objective. We show that the discriminatively reduced ensemble outperforms the state-of-the-art on three publicly available datasets and we introduce a new dataset for continuous car pose estimation in street scene images.
Gas-phase water and hydroxyl binding energies for monopositive first-row transition metal ions (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGas-phase water and hydroxyl binding energies for monopositive first-row transition metal ionsThomas F. Magnera, Donald E. David, and Josef MichlCite this: J. Am. Chem. Soc. 1989, 111, 11, 4100–4101Publication Date (Print):May 1, 1989Publication History Published online1 May 2002Published inissue 1 May 1989https://pubs.acs.org/doi/10.1021/ja00193a051https://doi.org/10.1021/ja00193a051research-articleACS PublicationsRequest reuse permissionsArticle Views529Altmetric-Citations198LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Hypoxia-induced IL-18 Increases Hypoxia-inducible Factor-1α Expression through a Rac1-dependent NF-κB Pathway (2007)

Interleukin-18 (IL-18) plays pivotal roles in linking inflammatory immune responses and tumor progression and metastasis, yet the manner in which this occurs remains to be sufficiently clarified. Here we report that hypoxia induces the transcription and secretion of IL-18, which subsequently induces the expression of hypoxia-inducible factor-1alpha (HIF-1alpha). Mechanistically, IL-18 induces HIF-1alpha through the activity of the GTPase Rac1, which inducibly associates with the IL-18 receptor beta (IL-18Rbeta) subunit, via a PI3K-AKT-NF-kappaB-dependent pathway. Importantly, the knockdown of the IL-18Rbeta subunit inhibited IL-18-driven tumor cell metastasis. Collectively, these findings demonstrate a feed-forward pathway in HIF-1alpha-mediated tumor progression, in which the induction of IL-18 by hypoxia or inflammatory cells augments the expression of both HIF-1alpha and tumor cell metastasis.
Functional properties of cardiac L-type calcium channels transiently expressed in HEK293 cells. Roles of alpha 1 and beta subunits. (1995)

The cardiac dihydropyridine-sensitive calcium channel was transiently expressed in HEK293 cells by transfecting the rabbit cardiac calcium channel alpha 1 subunit (alpha 1C) alone or in combination with the rabbit calcium channel beta subunit cloned from skeletal muscle. Transfection with alpha 1C alone leads to the expression of inward, voltage-activated, calcium or barium currents that exhibit dihydropyridine sensitivity and voltage- as well as calcium-dependent inactivation. Coexpression of the skeletal muscle beta subunit increases current density and the number of high-affinity dihydropyridine binding sites and also affects the macroscopic kinetics of the current. Recombinant alpha 1C beta channels exhibit a slowing of activation and a faster inactivation rate when either calcium or barium carries the charge. Our data suggest that both an increase in the number of channels as well as modulatory effects on gating underlie the modifications observed upon beta subunit coexpression.
A Geocoding Framework for Indoor Navigation based on the QR Code (2018)

Currently, indoor navigation has become a hotspot in the field of Location Based Service. However, there is no universal model to geocode and locate interior facilities. In this paper, the indoor space is constructed of three layers, including venue, room, and POI. Then a geocoding framework is proposed to encode each POI as a code including three parts, namely partition number, functional number and connectivity number. In contrast to most indoor navigation methods which use WIFI or RFID would necessitate extra cost of money, manpower, and maintenance, we take advantages of QR code, which is money saving and convenient, to restore the location information. Taking the library of Wuhan University as a sample area, a prototype implementing our method for indoor navigation is generated. On this basis, a mobile navigation electronic map is developed and implemented, which can provide services of indoor positioning and optimal path push in the library.
Photodriven Electron and Energy Transfer from a Light-Harvesting Metallodendrimer (2002)

Intermolecular electron and energy transfer from a light-harvesting metallodendrimer [Ru[bpy(C-450)(4)](3)](2+), where bpy(C-450)(4) is a 2,2'-bipyridine derivative containing 4 coumarin-450 units connected together through aryl ether linkages, is observed in acetonitrile solutions at room temperature. The model complex [Ru(dmb)(3)](2+), where dmb is 4,4'-dimethyl-2,2'-bipyridine, is included for quantitative comparison. The excited states of both compounds are metal-to-ligand charge transfer in nature and participate in excited-state electron and triplet energy transfer processes. Quenching constants were determined from luminescence and time-resolved absorption experiments at constant ionic strength. [Ru[bpy(C-450)(4)](3)](2+) displays significantly slower quenching rates to molecular oxygen and methyl viologen relative to the other processes investigated. Triplet energy transfer from [Ru[bpy(C-450)(4)](3)](2+) to 9-methylanthracene is quantitatively indistinguishable from [Ru(dmb)(3)](2+) while reductive electron transfer from phenothiazine was slightly faster in the former. With the exception of dioxygen quenching, our results indicate that the current dendritic structure is ineffective in shielding the core from bimolecular electron and triplet energy transfer reactions. Electrochemical measurements of [Ru[bpy(C-450)(4)](3)](2+) reveal irreversible oxidative processes at potentials slightly negative to the Ru(III/II) potential that are assigned to oxidations in the dendritic structure. Excited-state oxidative electron-transfer reactions facilitate this process resulting in the reduction of ground-state Ru(III) to Ru(II) and the trapping of the methyl viologen radical cation (MV(*+)) when methyl viologen serves as the quencher. This process generates a minimum of 9 MV(*+)'s for every [Ru[bpy(C-450)(4)](3)](2+) molecule and disassembles the metallodendrimer, resulting in the production of a [Ru(dmb)(3)](2+)-like species and "free" C-450-like dyes.
Sparse regression analysis of task-relevant information distribution in the brain (2012)

One of key topics in fMRI analysis is discovery of task-related brain areas. We focus on predictive accuracy as a better relevance measure than traditional univariate voxel activations that miss important multivariate voxel interactions. We use sparse regression (more specifically, the Elastic Net<sup>1</sup>) to learn predictive models simultaneously with selection of predictive voxel subsets, and to explore transition from task-relevant to task-irrelevant areas. Exploring the space of sparse solutions reveals a much wider spread of task-relevant information in the brain than it is typically suggested by univariate correlations. This happens for several tasks we considered, and is most noticeable in case of complex tasks such as pain rating; however, for certain simpler tasks, a clear separation between a small subset of relevant voxels and the rest of the brain is observed even with multivariate approach to measuring relevance.
Jean-Marie Augustin, Les substitutions fidéicommissaires à Toulouse et en Haut-Languedoc au XVIIIe siècle : famille et société, 1980 (1983)

Bart Jean. Jean-Marie Augustin, Les substitutions fidéicommissaires à Toulouse et en Haut-Languedoc au XVIIIe siècle : famille et société, 1980. In: Annales historiques de la Révolution française, n°251, 1983. pp. 171-172.
Immunofluorescence mapping, electron microscopy and genetics in the diagnosis and sub‐classification of inherited epidermolysis bullosa: a single‐centre retrospective comparative study of 87 cases with long‐term follow‐up (2020)

Transmission electron microscopy remains relevant to the diagnosis of EBS. IFM and genetics are essential and complementary tools in the vast majority of EB cases.
Protective action of the microbial metabolite butyrate against cardiomyocyte hypertrophy (2020)

Abstract Introduction Short-chain fatty acids are one of the gut microbial metabolites that may influence host physiology. We previously reported that gut dysbiosis was associated with heart failure, and that the proportions of butyrate-producing bacteria diminished prominently in the gut of patients with heart failure. Purpose We investigated the molecular mechanism of butyrate and investigated the protective mechanism against heart failure. Methods We searched for G protein-coupled receptors for short-chain fatty acids using single-cell transcriptome analysis of cardiomyocytes and non-cardiomyocytes isolated from murine hearts. In addition, we examined the effects of butyrate on endothelin-1 (ET1) or isoproterenol-induced hypertrophic responses and histone deacetylase (HDAC) activities in cultured neonatal rat cardiomyocytes. Results Single-cell transcriptome analysis and co-expression network analysis revealed that G protein-coupled receptors for short-chain fatty acid receptors were not expressed in cardiomyocytes and that Olfr78 was expressed in vascular smooth muscle cells in the heart. Treatment with butyrate inhibited ET1-induced hypertrophic growth and up-regulation of the genes such as Nppa, Acta1, and Myh7 in cultured rat neonatal cardiomyocytes. Moreover, butyrate increased the acetylation levels of histone H3, indicating that butyrate has an inhibitory effect on HDAC in cardiomyocytes. In addition, treatment with butyrate caused up-regulation of Inpp5f, encoding inositol polyphosphate-5-phosphatase f, which was associated with a significant decrease in the phosphorylation levels of Akt. These results suggest that butyrate may act as HDAC inhibitor to increase Inpp5f gene expression, leading to the activation of Akt-glycogen synthase kinase 3beta (Gsk3beta) pathway, and thereby protect against hypertrophic responses. Conclusion There was no known GPCR for short-chain fatty acid expressed in cardiomyocytes. However, butyrate suppressed cardiomyocyte hypertrophy through epigenetic modification of gene expression. Our results may uncover a potential role of the dysbiosis of intestinal microbiota in the pathogenesis of cardiac hypertrophy and failure. Funding Acknowledgement Type of funding source: None
Discriminators of mouse bladder response to intravesical Bacillus Calmette-Guerin (BCG) (2007)

To the best of our knowledge, the present work is the first to report that BCG induces an increase in the IL-17 family genes. In addition, BCG induces a unique type of persisting bladder inflammation different from TNF-alpha, LPS, and, most likely, other classical pro-inflammatory stimuli.
Robot Grasping through a Joint-Initiative Supervised Autonomy Framework (2022)

Robot grasping applications are faced with challenges and limitations leading to errors that affect their performance and accuracy. Although these errors are reduced in expensive industrial systems, low-cost robots are still prone to inaccurate perception and execution due to their limited hardware and software capabilities. To mitigate these challenges and limitations, this work develops a Joint-Initiative Supervised Autonomy (JISA) framework for robot grasping. In the proposed system, a human supervisor provides assistance to the robot's perception and planning modules, where the assistance is triggered by requests made by the robot based on its self confidence (SC) metric. Moreover, the human supervisor can also assist the robot in eliminating execution errors based on his/her situation awareness (SA). Through experimental validation, we show that including a human supervisor in the loop for grasping tasks in low-cost robots outperforms full autonomy. In fact, our proposed system showed a marked performance improvement by increasing the end-to-end success rate of the baseline approach, which we implemented JISA on, from 35.0% to 87.6%.