gebhart/patrepeval huggingface dataset:
Wearable motion sensors for the assessment of functional outcome following knee arthroplasty: a systematic scoping review protocol (2019)

A systematic scoping review to evaluate the current state of wearable sensor utilization in knee arthroplasty research
Treatment of Crack Cocaine Use with Carbamazepine (1992)

Crack is a rock crystalline alkaloid form of cocaine which can be smoked. At the University of Minnesota, we have developed an experimental pharmacologic treatment for cocaine abusers. Of 26 patients treated to date, 16 have been crack cocaine users. During the hundred days preceding treatment, the 16 crack subjects used cocaine by all routes an average of 71 days each. Improvement was based on a self-reported decrease in cocaine frequency of use. Using carbamazepine, seven highly successful and six partially successful patients reduced their use to 0.7 days and 26 days per 100 days, respectively. These results, though hopeful, must be viewed with caution and considered preliminary and tentative.
Targeting the kallikrein-kinin system as a new therapeutic approach to diabetic retinopathy. (2010)

Diabetic retinopathy (DR) is a major microvascular complication of diabetes mellitus that can lead to visual impairment and blindness. There is no approved pharmacological treatment for DR; however, laser therapy, steroids and anti-VEGF agents appear to provide some benefit. Hyperglycemia, advanced glycation end products, growth factors, and elevated levels of circulating and vitreous cytokines and chemokines can all trigger an inflammatory response of the retinal vasculature. Features of DR can include diabetic macular edema, microhemorrhage, loss of capillaries, development of avascular areas and the vitreo-retinal proliferation of neovessels. The kallikrein-kinin system (KKS) has long been recognized as a key player of inflammatory processes in various organs. Intravitreally administered recombinant plasma kallikrein has been demonstrated to produce retinal vascular leakage and hemorrhage, while both kinin B1 and B2 receptor agonists have induced retinal edema. Furthermore, kallikrein inhibitors and peptide-based B1 receptor antagonists could reduce or block retinal vascular permeability in diabetic rats. In a diabetic rat model, FOV-2304 (Fovea Pharmaceuticals SA), a non-peptide selective B1 receptor antagonist, consistently blocked retinal vascular permeability, inhibited leukocyte adhesion and abolished the retinal mRNA expression of several inflammatory mediators. Although additional studies are required to investigate the role of the KKS in early capillary loss and late-stage neovascularization processes, the blockade of the KKS is a promising therapeutic strategy for DR.
Successful use of an In Vivo Model of Spontaneous Angiogenesis as a Vascular Interface for an Implantable Bioartificial Hemofilter (2006)

The authors, as well as others, have previously shown that models of in vivo spontaneous angiogenesis are an ideal platform for the engineering of three-dimensional tissue constructs. In this reported experiment, they sought to investigate the ability of one such model to act as a vascular interface for the collection of ultrafiltrate to replace glomerular function.
Identification of functional regions on the I-Ab molecule by site-directed mutagenesis. (1986)

Functional analysis of mutant class II major histocompatibility complex molecules has begun to identify regions important for antibody binding and for T-cell activation. By using in vitro mutagenesis directed at the beta 1 domain of the Ab beta gene we have constructed three structurally distinct mutant Ab beta genes. Each of these genes, as well as the wild-type Ab beta gene, was cotransfected together with the wild-type Ab alpha gene into the Ia-negative B-lymphoma cell line M12.C3. Transfection resulted in the successful synthesis and cell surface expression of three mutant class II antigens that showed serological and functional alterations as compared to the I-Ab antigens from the M12.C3 cell transfected with the wild-type gene. The variable patterns of both I-Ab-specific monoclonal antibody binding and activation of I-Ab-specific T-cell hybridomas show that the mutations result in the loss of structural epitopes required for both monoclonal antibody binding and for T-cell recognition. The data suggest that there are multiple sites on a single Ia molecule that are recognized by T helper cells and also that the tertiary conformation of the Ia molecule can be critical in the formation of such sites.
PROGNOSTIC FACTORS FOR METASTATIC RENAL CELL CANCER (1995)

We examined various prognostic factors of metastatic renal cell carcinoma. Patients who had metastasis at nephrectomy (A group, 38 cases) and those who had metastasis as recurrent tumors after nephrectomy (B group, 38 cases) entered in this study. Five-year survival rate of total cases after confirmation of metastatic foci was 15% and there was no statistical significant difference between A and B groups. Several pathological factors were related to poorer prognosis and included large diameters of original tumors, positive lymph nodes, higher grade tumors and non-clear cell type tumors. Patients who have a solitary lung metastasis showed better prognosis compared to those with multiple lung metastases or metastases of other organs. Two factors related to treatment were shown to contribute to better prognosis. These were the response to interferon alfa (IFN alpha) and the possibility of total resection of visible metastatic tumors. Patients who belong to A group were shown to achieve markedly better therapeutic benefit from IFN alpha or IFN alpha plus anticancer drugs. Five-year survival rate for the responders was 40%, as compared to less than 5% for the non-responders. Ten-year survival rate for patients with metastasis who had undergone complete resection of visible tumor was 50%, and the for patients belonging to B group Showed 80%. We concluded that these prognostic factors should be considered to decide how to select patients with metastatic renal cell cancer.
Hybrid Symbolic-Numeric Library for Power System Modeling and Analysis (2020)

With the recent booming of open-source packages for scientific computing, power system simulation is being revisited to reduce the programming efforts for modeling and analysis. Existing open-source tools require manual efforts to develop code for numerical equations and sparse Jacobians. Such work would become repeated, tedious and error-prone when a researcher needs to implement complex models with a large number of equations. This paper proposes a two-layer hybrid library consisted of a symbolic layer for descriptive modeling and a numeric layer for vector-based numerical computation. The open-source library allows to implement differential-algebraic equation (DAE)-based models with descriptive equation strings, which will be transparently generated into robust and fast numerical simulation code and high-quality documentation. Thus, complex models and systems can be easily prototyped and simulated. These two layers are decoupled so that the symbolic layer is case-independent, and existing numerical programs can be reused. Implementation details in indexing, equation evaluation, and Jacobian evaluation are discussed. Case studies present a) implementation of turbine governor model TGOV1, b) the power flow calculation for MATPOWER test systems, c) the validation against commercial software using Kundur's two-area system with GENROU, EXDC2 and TGOV1 models, and d) the full eigenvalue analysis for Kundur's system.
Correction to “Consequences of Grafting Density on Linear Viscoelastic Behavior of Graft Polymers” (2018)

ADVERTISEMENT RETURN TO ISSUEPREVCorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to "Consequences of Grafting Density on Linear Viscoelastic Behavior of Graft Polymers"Ingrid N. HauganIngrid N. HauganMore by Ingrid N. Hauganhttp://orcid.org/0000-0002-8406-8939, Michael J. MaherMichael J. MaherMore by Michael J. Maherhttp://orcid.org/0000-0003-0577-3726, Alice B. ChangAlice B. ChangMore by Alice B. Changhttp://orcid.org/0000-0001-5036-2681, Tzu-Pin LinTzu-Pin LinMore by Tzu-Pin Linhttp://orcid.org/0000-0001-7041-7213, Robert H. GrubbsRobert H. GrubbsMore by Robert H. Grubbshttp://orcid.org/0000-0002-0057-7817, Marc A. HillmyerMarc A. HillmyerMore by Marc A. Hillmyerhttp://orcid.org/0000-0001-8255-3853, and Frank S. Bates*Frank S. BatesMore by Frank S. Bateshttp://orcid.org/0000-0003-3977-1278Cite this: ACS Macro Lett. 2018, 7, 8, 1039Publication Date (Web):August 10, 2018Publication History Received7 August 2018Published online10 August 2018Published inissue 21 August 2018https://pubs.acs.org/doi/10.1021/acsmacrolett.8b00592https://doi.org/10.1021/acsmacrolett.8b00592correctionACS PublicationsCopyright © 2018 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1301Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (420 KB) Get e-AlertscloseSUBJECTS:Chromatography,Graft polymerization,Polymers,Theoretical and computational chemistry Get e-Alerts
MOLECULAR GENETIC ANALYSIS OF THE DILUTE-SHORT EAR (d-se) REGION OF THE MOUSE (1986)

Genes of the dilute-short ear (d-se) region of mouse chromosome 9 comprise an array of loci important to the normal development of the animal. Over 200 spontaneous, chemically induced and radiation-induced mutations at these loci have been identified, making it one of the most genetically well-characterized regions of the mouse. Molecular analysis of this region has recently become feasible by the identification of a dilute mutation that was induced by integration of an ecotropic murine leukemia virus genome. Several unique sequence cellular DNA probes flanking this provirus have now been identified and used to investigate the organization of wild-type chromosomes and chromosomes with radiation-induced d-se region mutations. As expected, several of these mutations are associated with deletions, and, in general, the molecular and genetic complementation maps of these mutants are concordant. Furthermore, a deletion breakpoint fusion fragment has been identified and has been used to orient the physical map of the d-se region with respect to the genetic complementation map. These experiments provide important initial steps for analyzing this developmentally important region at the molecular level, as well as for studying in detail how a diverse group of mutagens acts on the mammalian germline.
A FREQUENCY DOMAIN ADAPTIVE ALGORITHM FOR WAVE SEPARATION (2009)

We propose a frequency domain adaptive algorithm for wave separation in wind instruments. Forward and backward travelling waves are obtained from the signals acquired by two microphones placed along the tube, while the separation filter is adapted from the information given by a third microphone. Working in the frequency domain has a series of advantages, among which are the ease of design of the propagation filter and its differentiation with respect to its parameters. Although the adaptive algorithm was developed as a first step for the estimation of playing parameters in wind instruments it can also be used, without any modifications, for other applications such as in-air direction of arrival (DOA) estimation. Preliminary results on these applications will also be presented.
U. S. EPA's manual of practice for the investigation and control of cross-connection pollution into storm drainage systems (1992)

Dry-weather flows discharging from storm drainage systems can contribute significant pollutant loadings to receiving waters. If these loadings are ignored, little improvement in receiving water conditions may occur with many stormwater control programs. The paper summarizes the first phase of an EPA sponsored research project to develop a manual to investigate these connections to assist local governments in identifying the magnitude and sources of cross-connections in their storm drainage systems.
ChemInform Abstract: Symbolic Equations and Their Applications to Reaction Design (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The Evolving Tree: a new kind of self-organizing neural network (2003)

This paper presents a new neural network system called the Evolving Tree. This network resembles the Self-Organizing map, but deviates from it in several aspects, which are desirable in many analysis tasks. First of all the Evolving Tree grows automatically, so the user does not have to decide the network’s size before training. Secondly the network has a hierarchical structure, which makes network training and use computationally very efficient. Test results with both synthetic and actual data show that the Evolving Tree works quite well. 1
Preparation of a series of mesoporous lanthanide oxides by a neutral supramolecular templating routeElectronic supplementary information (ESI) available: DSC results. See http://www.rsc.org/suppdata/jm/b3/b313982d/ (2004)

In this study, data are provided that detail the first preparation of high surface area and structurally ordered mesoporous lanthanide oxides by a neutral surfactant supramolecular templating route. For the first time, retention of mesoporosity in lanthanide oxides (other than those of cerium) after surfactant removal by simple air calcination at temperatures to 450 °C is demonstrated. The as-prepared lanthanide–surfactant composites displayed long range ordering of the mesoporous phase and although significant amounts of order can be lost, the materials exhibit a large degree of porosity, high surface area and some ordering of the pore array after high temperature calcination. In the case of lanthanum oxide, a mesoporous material displaying a cubic structured array of pores was obtained. The heavier lanthanide analogues readily formed lamellar phases. Removal of water and surfactant from between lamellae was found to result in some collapse of the as-prepared porous structures although in all cases mesoporosity was still evident. Ytterbium was found to exhibit more complex behaviour with a cubic phase being generated. This material was also found to display reduced periodicity of the pore structure on calcination and all materials retained highly textured surfaces after the thermal treatment to remove surfactant.
The Genetic Algorithm: Foundations and Apllications in Structure Solution from Powder Diffraction Data (1998)

Recently, new methods based on the use of genetic algorithms have been explored and developed for solving crystal structures directly from powder diffraction data. In implementing genetic algorithms in such applications, several different aspects of the technique and strategy are open to optimization, leading to a versatile and powerful approach. In this paper, the fundamental concepts underlying genetic algorithms are discussed and the implementation of the genetic algorithm for structure solution from powder diffraction data is described. The opportunities, scope and potential for future developments in the foundations and applications of genetic algorithms in this field are highlighted. The genetic algorithm approach adopts the `direct-space' philosophy for structure solution, with trial structures generated independently of the experimental diffraction data and the quality of each structure assessed by comparing the calculated and experimental powder diffraction patterns; in this work, this comparison is made using the profile R factor Rwp. In the genetic algorithm, a population of trial structures is allowed to evolve subject to well defined rules governing mating, mutation and `natural selection'. The `fitness' of each structure in the population is a function of its profile R factor. The successful application of the genetic algor­ithm approach for structure solution of molecular crystals from powder diffraction data is demonstrated with examples of previously known and previously unknown structures.
Variable temperature fluid stage for atomic force microscopy (2000)

The design of a simple, variable temperature fluid cell for an atomic force microscope is presented. The stage is based on a thermoelectric heating/cooling element, which allows control of sample and fluid temperature from −5 to 130 °C. The stage is stable enough to image at molecular resolution almost throughout the range of accessible temperature and can be used for imaging in either gas or liquids. This allows the molecular scale investigation of surface phase transitions and chemical kinetics at solid/liquid interfaces by varying the temperature. As an example, we present results of temperature-induced phase transitions in self-assembled surfactant aggregates at solid/liquid interfaces.
Pyroptosis and adaptive immunity mechanisms are promptly engendered in mesenteric lymph-nodes during pig infections with Salmonella enterica serovar Typhimurium (2013)

In this study, we explored the transcriptional response and the morphological changes occurring in porcine mesenteric lymph-nodes (MLN) along a time course of 1, 2 and 6 days post infection (dpi) with Salmonella Typhimurium. Additionally, we analysed the expression of some Salmonella effectors in tissue to complete our view of the processes triggered in these organs upon infection. The results indicate that besides dampening apoptosis, swine take advantage of the flagellin and prgJ expression by Salmonella Typhimuriun to induce pyroptosis in MLN, preventing bacterial dissemination. Furthermore, cross-presentation of Salmonella antigens was inferred as a mechanism that results in a rapid clearance of pathogen by cytotoxic T cells. In summary, although the Salmonella Typhimurium strain employed in this study was able to express some of its major virulence effectors in porcine MLN, a combination of early innate and adaptive immunity mechanisms might overcome virulence strategies employed by the pathogen, enabling the host to protect itself against bacterial spread beyond gut-associated lymph-nodes. Interestingly, we deduced that clathrin-mediated endocytosis could contribute to mechanisms of pathogen virulence and/or host defence in MLN of Salmonella infected swine. Taken together, our results are useful for a better understanding of the critical protective mechanisms against Salmonella that occur in porcine MLN to prevent the spread of infection beyond the intestine.
Resins with the ability to bind copper and uranyl ions (2005)

Abstract Crosslinked poly(1‐vinyl imidazole‐ co ‐acrylic acid) and crosslinked poly(1‐vinylmidazole‐ co ‐2‐acrylamido‐2‐methyl‐1‐propanesulfonic acid) were synthesized by radical polymerization and characterized by elemental analysis and FTIR spectroscopy. The polymerization yields were 79 and 99%, respectively. The metal ion binding properties for copper(II) and uranium(VI) were studied under noncompetitive and competitive conditions by Batch equilibrium procedure. The resin crosslinked poly(1‐vinyl imidazole‐ co ‐acrylic acid) showed a higher dependence on pH than crosslinked poly(1‐vinylmidazole‐ co ‐2‐acrylamido‐2‐methyl‐1‐propanesulfonic acid). The retention of uranyl ions for the latter resin was close to 100% at pH 5.0. The higher maximum retention capacity was close to 0.8 mmol/g dry resin at pH 5.0. Regeneration of the resin was possible by treatment with basic eluent. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 99: 706–711, 2006
Allosteric Regulation of Serine Protease HtrA2 through Novel Non-Canonical Substrate Binding Pocket (2013)

HtrA2, a trimeric proapoptotic serine protease is involved in several diseases including cancer and neurodegenerative disorders. Its unique ability to mediate apoptosis via multiple pathways makes it an important therapeutic target. In HtrA2, C-terminal PDZ domain upon substrate binding regulates its functions through coordinated conformational changes the mechanism of which is yet to be elucidated. Although allostery has been found in some of its homologs, it has not been characterized in HtrA2 so far. Here, with an in silico and biochemical approach we have shown that allostery does regulate HtrA2 activity. Our studies identified a novel non-canonical selective binding pocket in HtrA2 which initiates signal propagation to the distal active site through a complex allosteric mechanism. This non-classical binding pocket is unique among HtrA family proteins and thus unfolds a novel mechanism of regulation of HtrA2 activity and hence apoptosis.