gebhart/patrepeval huggingface dataset:
Potential of Augmented Reality Platforms to Improve Individual Hearing Aids and to Support More Ecologically Valid Research (2020)

An augmented reality (AR) platform combines several technologies in a system that can render individual "digital objects" that can be manipulated for a given purpose. In the audio domain, these may, for example, be generated by speaker separation, noise suppression, and signal enhancement. Access to the "digital objects" could be used to augment auditory objects that the user wants to hear better. Such AR platforms in conjunction with traditional hearing aids may contribute to closing the gap for people with hearing loss through multimodal sensor integration, leveraging extensive current artificial intelligence research, and machine-learning frameworks. This could take the form of an attention-driven signal enhancement and noise suppression platform, together with context awareness, which would improve the interpersonal communication experience in complex real-life situations. In that sense, an AR platform could serve as a frontend to current and future hearing solutions. The AR device would enhance the signals to be attended, but the hearing amplification would still be handled by hearing aids. In this article, suggestions are made about why AR platforms may offer ideal affordances to compensate for hearing loss, and how research-focused AR platforms could help toward better understanding of the role of hearing in everyday life.
Global and Temporal COVID-19 Risk Evaluation (2020)

The COVID-19 pandemic has caused unprecedented crisis across the world, with many countries struggling with the pandemic. In order to understand how each country is impacted by the virus and assess the risk on a global scale we present a regression based analysis using two pre-existing indexes, namely the Inform and Infectious Disease Vulnerability Index, in conjunction with the number of elderly living in the population. Further we introduce a temporal layer in our modeling by incorporating the stringency level employed by each country over a period of 6 time intervals. Our results show that the indexes and level of stringency are not ideally suited for explaining variation in COVID-19 risk, however the ratio of elderly in the population is a stand out indicator in terms of its predictive power for mortality risk. In conclusion, we discuss how such modeling approaches can assist public health policy.
Increasing Latex in Pine Seed Coating Impairs Repellency and Germination (1979)

Abstract The repellent currently recommended for protecting pine seeds sown directly contains 2 gallons Arasan 42-S, I pound Endrin 50-W, and 10 ounces latex per 100 pounds of seed. Weathering prior to germination causes some repellent loss but seed protection from rodents is not significantly decreased. Greater amounts of latex allow more depredations by several rodent species and decrease germination.
TCR engineered T cell therapy from concepts to clinic (2019)

The increased understanding of the human immune system and its ability to detect and eradicate tumor cells has led to a promising wave of novel therapeutics which have the potency to become the new standard of care. This thesis aims to contribute to the development of novel cell therapy products and the GMP manufacturing thereof.
Sprouting, regeneration and circuit formation in the injured spinal cord: factors and activity (2006)

Central nervous system (CNS) injuries are particularly traumatic, owing to the limited capabilities of the mammalian CNS for repair. Nevertheless, functional recovery is observed in patients and experimental animals, but the degree of recovery is variable. We review the crucial characteristics of mammalian spinal cord function, tract development, injury and the current experimental therapeutic approaches for repair. Regenerative or compensatory growth of neurites and the formation of new, functional circuits require spontaneous and experimental reactivation of developmental mechanisms, suppression of the growth-inhibitory properties of the adult CNS tissue and specific targeted activation of new connections by rehabilitative training.
Assessing UAV Landslide Mapping Using Unmanned Aerial Vehicle (UAV) for Landslide Mapping Activity (2014)

The purpose of this research is to improve the landslide mapping using unmanned aerial vehicle (UAV) for the area of slope displacement. It further presents the UAV namely multi-motor that being used to capture images at the research area located in Parit, Perak. The objective of this research paper is to develop a three dimensional of landslide area produced from the UAV images. For the whole process of image processing, thirty six control points are established using global positioning system (GPS) staic mehtod using Agisoft Photoscan. The results show that the digital elevation model (DEM), aspect Model, slope model, and digital orthophoto can be obtained using the procedure and method used in the study. The information is obtained through accurate assessment results and used to create a 3D model which is then used to monitor technique applications. The restitution stereo model is also by three dimensional rotations or transformation in 3D surface. From here, the landslide can be detected by calculation of three difference epoch data achieved from Digital Elevation Model (DEM) generation. Prior to that, this paper focuses on the monitoring of that area based on DEM area and volume generated from 3D surface analysis. To conclude this study shows that UAV can be used for producing digital map.
Quantifying Defects in Graphene via Raman Spectroscopy at Different Excitation Energies (2011)

We present a Raman study of Ar(+)-bombarded graphene samples with increasing ion doses. This allows us to have a controlled, increasing, amount of defects. We find that the ratio between the D and G peak intensities, for a given defect density, strongly depends on the laser excitation energy. We quantify this effect and present a simple equation for the determination of the point defect density in graphene via Raman spectroscopy for any visible excitation energy. We note that, for all excitations, the D to G intensity ratio reaches a maximum for an interdefect distance ∼3 nm. Thus, a given ratio could correspond to two different defect densities, above or below the maximum. The analysis of the G peak width and its dispersion with excitation energy solves this ambiguity.
Determination of nuclear magnetic resonance T2 cutoff value based on multifractal theory — An application in sandstone with complex pore structure (2014)

ABSTRACT The cutoff value of nuclear magnetic resonance (NMR) transversal relaxation time T2 is vital for pore structure characterization, permeability prediction, and irreducible water saturation calculation. Conventional default values often lead to inaccurate results for rocks with complex pore structure. Based on NMR experiments and multifractal theory, we have developed an effective statistical method to predict T2 cutoff values without other petrophysical information. The method is based on multifractal theory to analyze the NMR T2 spectrum with the assumption that the T2 spectrum is an indicator of pore size distribution. Multifractal parameters, such as multifractal dimension, singularity strength, and mass exponent, are calculated to investigate the multifractal behavior of T2 spectrum via NMR experiments and a dyadic scaling-down algorithm. To obtain the optimal T2 cutoff value, the rotation speed and time of centrifugation are enlarged increasingly to optimal centrifugal state. A predicating model for T2 cutoff value based on multiple linear regressions of multifractal parameters was proposed after studying the influential factors. On the basis of the multifractal analysis of NMR T2 spectrum, a reasonable predication model for T2 cutoff value was rendered. Upon testing, the predicted results were highly consistent with the experimental results.
Improvement of Bacillus circulans β-amylase activity attained using the ancestral mutation method (2010)

Thermostabilization of enzymes is one of the greatest challenges of protein engineering. The ancestral mutation method, which introduces ancestral residues into a target enzyme, has previously been developed and used to improve the thermostabilities of thermophilic enzymes. Herein, we report a study that used the ancestral mutation method to improve the thermostability of Bacillus circulans beta-amylase, a mesophilic enzyme. A bacterial, common-ancestral beta-amylase sequence was inferred using a phylogenetic tree composed of higher plant and bacterial amylase sequences. Eighteen mutants containing ancestral residues were designed, expressed in Escherichia coli and purified. Several of these mutants were more thermostable than that of the wild-type amylase. Notably, one mutant had both greater activity and greater thermostability. The relationship between the extent to which the amino acid residues within 5 A of the mutation site were evolutionarily conserved and the extent to which thermostability was improved was examined. Apparently, it is necessary to conserve the residues surrounding an ancestral residue if thermostability is to be improved by the ancestral mutation method.
Detection of successive changes in dynamics of EEG time series: linear and nonlinear approach (2002)

Interesting results have been reported on the quantitative description of EEG patterns, based on the assumption either about linear stochastic dynamics, or chaotic dynamics. Thus the question arises of whether linear or non-linear methods are to be used in the EEG analysis. This study was undertaken to reveal the dynamic behavior of EEG activity during performance of a voluntary motor task. Using autoregressive models and Kalman filtering on one side and nonlinear prediction of the other side, successive changes from linear stochastic to chaotic dynamics of short-term segments of EEG time series were found in single-trial records. This suggests that EEG activity should be processed in parts since different steady states are separated by shorter chaotic transients.
CRISPR-based kinome-screening revealed MINK1 as a druggable player to rewire 5FU-resistance in OSCC through AKT/MDM2/p53 axis (2022)

Abstract Cisplatin, 5FU and docetaxel (TPF) are the most common chemotherapy regimen used for advanced OSCC. However, many cancer patients experience relapse, continued tumor growth, and spread due to drug resistance, which leads to treatment failure and metastatic disease. Here, using a CRISPR/Cas9 based kinome knockout screening, Misshapen-like kinase 1 (MINK1) is identified as an important mediator of 5FU resistance in OSCC. Analysis of clinical samples demonstrated significantly higher MINK1 expression in the tumor tissues of chemotherapy non-responders as compared to chemotherapy responders. The nude mice and zebrafish xenograft experiments indicate that knocking out MINK1 restores 5FU mediated cell death in chemoresistant OSCC. An antibody based phosphorylation array screen revealed MINK1 as a negative regulator of p53. Mechanistically, MINK1 modulates AKT phosphorylation at Ser473, which enables p-MDM2 (Ser 166) mediated degradation of p53. We also identified lestaurtinib as a potent inhibitor of MINK1 kinase activity. The patient derived TPF resistant cell based xenograft data suggest that lestaurtinib restores 5FU sensitivity and facilitates a significant reduction of tumor burden. Overall, our study suggests that MINK1 is a major driver of 5FU resistance in OSCC. The novel combination of MINK1 inhibitor lestaurtinib and 5FU needs further clinical investigation in advanced OSCC.
Identification of Gliadin Presence in Pharmaceutical Products (1994)

Celiac disease is characterized by hypersensitivity to the alcohol-soluble wheat proteins called gliadins. Total avoidance of gliadin is the lifelong treatment for such patients. However, wheat gliadins are often present as impurities in industrial starch commonly used in the preparation of different pharmaceutical products. Therefore, some drugs might contain gliadin, which can be dangerous for sensitive patients if taken in large amounts or used permanently. The purpose of this study was to develop a sensitive, reliable assay that is specific for the detection of gliadins in pharmaceutical products. Gliadins were extracted here using sodium dodecyl sulfate rather than 70% ethyl alcohol, which has been the traditional solvent. This gliadin extract was utilized in a dot-blot assay that incorporated an antigliadin antibody developed in rabbit and labeled with peroxidase. 4-Chloro-1-naphthol was used as a peroxidase-specific substrate. Isolated wheat gliadin was used as the positive control. Dilution experiments showed that the lower level of sensitivity for the assay was in the range of 0.0045 mg/ml of gliadin, which is a concentration level lower than that suggested for a gluten-free diet. The assay developed here revealed that 71.2% of 59 prescription and nonprescription drugs tested contained gliadin in the amount detected by our dot-blot assay. The prescription drugs tested were among the top 50 most frequently dispensed in U.S. community pharmacies. The nonprescription drugs were among those that constitute the largest sales in the United States. The results showed that the simple dot-blot assay developed here can be used for pharmaceutical testing performed either by hospital laboratories or by patients themselves.
On the Potential for Entangled States Between Chaotic Systems (2014)

We report on the tendency of chaotic systems to be controlled onto their unstable periodic orbits in such a way that these orbits are stabilized. The resulting orbits are known as cupolets and collectively provide a rich source of qualitative information on the associated chaotic dynamical system. We show that pairs of interacting cupolets may be induced into a state of mutually sustained stabilization that requires no external intervention in order to be maintained and is thus considered bound or entangled. A number of properties of this sort of entanglement are discussed. For instance, should the interaction be disturbed, then the chaotic entanglement would be broken. Based on certain properties of chaotic systems and on examples which we present, there is further potential for chaotic entanglement to be naturally occurring. A discussion of this and of the implications of chaotic entanglement in future research investigations is also presented.
No Beneficial Effect of Two-Layer Storage Compared With UW-Storage on Human Islet Isolation and Transplantation (2007)

The present study suggests that the ischemic tolerance of human pancreata cannot be extended by TLM preservation. In addition, TLM does not seem to improve the isolation outcome for pancreata from elderly donors.
Fatty Acid Binding Protein Deletion Suppresses Inflammatory Pain through Endocannabinoid/N-Acylethanolamine-Dependent Mechanisms (2015)

This study demonstrates that mice lacking FABPs possess elevated levels of N-acylethanolamines, consistent with the idea that FABPs regulate the endocannabinoid and N-acylethanolamine tone in vivo. The antinociceptive effects observed in the knockout mice support a role for FABPs in regulating nociception and suggest that these proteins should serve as targets for the development of future analgesics.
Efficacité énergétique et captage de CO2 dans les centrales thermiques (2016)

International audience
Interim research assessment 2003-2005 - Computer Science (2007)

This report primarily serves as a source of information for the 2007 Interim Research Assessment Committee for Computer Science at the three technical universities in the Netherlands. The report also provides information for others interested in our research activities.
Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue. (1995)

Prolactin (PRL) induces transcriptional activation of milk protein genes, such as the whey acidic protein (WAP), beta-casein, and beta-lactoglobulin genes, through a signaling cascade encompassing the Janus kinase Jak2 and the mammary gland factor (MGF; also called Stat5), which belongs to the family of proteins of signal transducers and activators of transcription (STAT). We isolated and sequenced from mouse mammary tissue Stat5 mRNA and a previously unreported member, which we named Stat5b (Stat5 is renamed to Stat5a). On the protein level Stat5a and Stat5b show a 96% sequence similarity. The 5' and 3' untranslated regions of the two mRNAs are not conserved. Stat5a comprises 793 amino acids and is encoded by a mRNA of 4.2 kb. The Stat5b mRNA has a size of 5.6 kb and encodes a protein of 786 amino acids. Both Stat5a and Stat5b recognized the GAS site (gamma-interferon-activating sequence; TTCNNNGAA) in vitro and mediated PRL-induced transcription in COS cells transfected with a PRL receptor. Stat5b also induced basal transcription in the absence of PRL. Similar levels of Stat5a and Stat5b mRNAs were found in most tissues of virgin and lactating mice, but a differential accumulation of the Stat5 mRNAs was found in muscle and mammary tissue. The two RNAs are present in mammary tissue of immature virgin mice, and their levels increase up to day 16 of pregnancy, followed by a decline during lactation. The increase of Stat5 expression during pregnancy coincides with the activation of the WAP gene.
Buy or Sell? Energy Sharing of Prosumers on Constrained Networks (2019)

The advent of intelligent agents who produce and consume energy by themselves has led the smart grid into the era of "prosumer", offering the energy system and customers a unique opportunity to revaluate/trade their spot energy via a sharing initiative. To this end, designing an appropriate sharing mechanism is an issue with crucial importance and has captured great attention. This paper addresses the prosumers' demand response problem via energy sharing. Under a general supply-demand function bidding scheme, a sharing market clearing procedure considering network constraints is proposed, which gives rise to a generalized Nash game. The existence and uniqueness of market equilibrium are proved in non-congested cases. When congestion occurs, infinitely much equilibrium may exist because the strategy spaces of prosumers are correlated. A price-regulation procedure is introduced in the sharing mechanism, which outcomes a unique equilibrium that is fair to all participants. Properties of the improved sharing mechanism, including the individual rational behaviors of prosumers and the components of sharing price, are revealed. When the number of prosumers increases, the proposed sharing mechanism approaches social optimum. Even with fixed number of resources, introducing competition can result in a decreasing social cost. Illustrative examples validate the theoretical results and provide more insights for the energy sharing research.
Using brain-computer interfaces for implicit input (2014)

Passive brain-computer interfaces, in which implicit input is derived from a user's changing brain activity without conscious effort from the user, may be one of the most promising applications of brain-computer interfaces because they can improve user performance without additional effort on the user's part. I seek to use physiological signals that correlate to particular brain states in order to adapt an interface while the user behaves normally. My research aims to develop strategies to adapt the interface to the user and the user's cognitive state using functional near-infrared spectroscopy (fNIRS), a non-invasive, lightweight brain-sensing technique. While passive brain-computer interfaces are currently being developed and researchers have shown their utility, there has been little effort to develop a framework or hierarchy for adaptation strategies.
Control strategy for upper-limb prostheses (2002)

Designers of arm prosthesis control mechanisms have generally been guided by a designer's previous experience and his or her innovative thinking. In this paper, a design strategy guided by some theoretical control concepts and physiological knowledge is described. A preliminary design based on this strategy is proposed. However, as Stephen Toulmin has pointed out, "Theory has to answer to the high court of practice." Our laboratory still has limited clinical experience and practice with this design procedure.
Inter-eye relationship of intraocular pressure change after unilateral trabeculectomy, filtering canaloplasty, or PreserFlo™ microshunt implantation (2021)

This study shows an IOP-lowering effect in the fellow eye of glaucoma patients after trabeculectomy. Significant IOP rise might occur in the fellow eye of some glaucoma patients after different types of glaucoma surgery.
Supplementary Data from VPRBP Functions Downstream of the Androgen Receptor and OGT to Restrict p53 Activation in Prostate Cancer (2023)

Supplementary Data from VPRBP Functions Downstream of the Androgen Receptor and OGT to Restrict p53 Activation in Prostate Cancer
Novel Semiconductor Technologies of ZnO Films towards Ultraviolet LEDs and Invisible FETs (2000)

We present never semiconductor technologies of ZnO epitaxial films with using laser molecular-beam epitaxy method. Exciting optical properties such as room temperature lasing in ZnO nanocrystalline films and quantum size effects in ZnO/MgxZn1-xO superlattices were observed. By develop ing crystalline quality with using lattice-matched substrates, we could control resistivity of the doped ZnO films from 10(-3) Ohmm to 10(4) Ohm cm. These results would provide us an opportunity to construct a monolithic array consisted of light emitting devices and field effect transistors towards a possible flat panel display.
Outcomes of Medial Collateral Ligament Injuries during Total Knee Arthroplasty (2014)

Intraoperative medial collateral ligament (MCL) disruption during total knee arthroplasty (TKA) is often managed with either primary repair or use of a constrained implant. A total of 23 patients with an MCL injury during TKA between 2003 and 2009 were compared with 92 matched controls. Of the 23 patients, 10 were treated with an unconstrained implant and primary MCL repair, 8 with constrained implants, 3 with constrained implants and MCL repair, and 2 with unconstrained implants and no MCL repair. After an average 5-year follow-up, patients had lower Knee Society Scores (KSS), 79 versus 87 (p = 0.03), but similar Knee Function Scores (KFS), 68 versus 72 (p = 0.35). The improvement between preoperative and postoperative KSS and KFS did not vary among the two groups (p = 0.88 and p = 0.77, respectively). Postoperative scores did not vary significantly among the four treatment modalities. Conservative treatment can provide satisfactory outcomes and avoid potential complications of increased constraint.