gebhart/patrepeval huggingface dataset:
LaSrMn0.5Ni0.5O4+δ: spin and oxidation state in the K2NiF4 structure (1998)

Magnetic and structural data on the K2NiF4 structure oxide LaSrMn0.5Ni0.5O4+δare reported. Powder X-ray and electron diffraction show that the samples adopt the tetragonalI4/mmm space group without cation ordering. The absence of cation ordering together with structural considerations and magnetic data indicate that both cations are in the +III oxidation state, with high spin NiIII in contrast to both the three-dimensional perovskite LaMn0.5Ni0.5O3 and the K2NiF4 phase LaSrCr0.5Ni0.5O4 . The spin and oxidation state distributions account for the suppression of the antiferromagnetic long-range order of LaSrMnO4 and the observation of hysteresis characteristic of spin- or cluster glass behaviour below 90 K. The irreversible magnetism, but not that in the high-temperature Curie–Weiss region, is slightly altered by annealing single phase samples. The higher divergence temperature in the annealed sample is consistent with greater homogeneity of the cation distribution, as found for canonical RKKY spin glasses.
Direct solid-phase chemiluminescence immunoassay for salivary progesterone. (1986)

A simple, direct chemiluminescence immunoassay for progesterone in mixed, unstimulated saliva is described. We use purified polyclonal anti-progesterone antibodies covalently coupled to polyacrylamide beads and progesterone-11 alpha-hemisuccinyl-aminobutylethyl isoluminol as the chemiluminescent ligand marker. Bound and free ligand are separated by simple centrifugation. The detection limit of the assay is 1.5 pg per tube (38 pmol/L). Intra- and interassay coefficients of variation for low, medium, and high progesterone concentrations are 7.9, 6.8, 8.8% and 9.3, 6.9, 8.5%, respectively. Analytical recovery of added progesterone is 99.6%. Mean +/- SD progesterone concentrations (pmol/L) in saliva are 178 +/- 46 in the follicular phase, 313 +/- 90 in the periovulatory phase, and 658 +/- 166 in the luteal phase of the menstrual cycle. Correlation between progesterone concentrations in serum (assayed by RIA after extraction) and in saliva is good (r = 0.88, p less than 0.001, n = 96). The assay is simple, fast (4 h, including 1.5 h of incubation time), and reliable.
Asynchronous functional reactive programming for GUIs (2013)

Graphical user interfaces (GUIs) mediate many of our interactions with computers. Functional Reactive Programming (FRP) is a promising approach to GUI design, providing high-level, declarative, compositional abstractions to describe user interactions and time-dependent computations. We present Elm, a practical FRP language focused on easy creation of responsive GUIs. Elm has two major features: simple declarative support for Asynchronous FRP; and purely functional graphical layout.
Application of Computational Fluid Dynamics for Parametric Optimization of Jet-Type P/W/C Technique (2020)

Abstract Perforate-Wash-Cement (P/W/C) is a well plugging technique extensively used by ConocoPhillips in the Greater Ekofisk Area over the last ten years. In Jet-type P/W/C, Tubing Conveyed Perforating (TCP) guns perforate casing in the target interval before the zone is washed and a cross-sectional cement plug is installed using a specialized Bottom Hole Assembly (BHA). The goal is to maximize the cement plug quality through optimizing the BHA and operational process parameters within constraints imposed by the operating conditions. This paper describes application of Computational Fluid Dynamics (CFD) to achieve this objective. CFD is well suited for modeling wash and cement processes including the associated non-Newtonian fluids. A CFD model of these processes employs unsteady multiphase Reynolds Averaged Navier Stokes (RANS) based Volume of Fluid (VOF) approach with a Shear Stress Transport (SST) K-omega turbulence model. BHA translation and rotation are simulated using moving deforming-layering mesh with interface approach. Physical properties of non-Newtonian fluids selected are based on in-situ conditions and derived via lab tests. CFD-specific considerations such as domain size, turbulence model, mesh type and size, and computational timestep are discussed in this paper. The magnitude and duration of the jet-induced "pressure pulse" in the annular space between the formation wall and the casing are a key to efficient displacement during the wash and cementing processes. Displacement efficiency, in terms of the percentage of mud or cement in a control volume as a function of time, depends on perforation size and density, nozzle size/number, flow rate, fluid properties, as the ROP/BHA pulling speed and tool RPM. Key findings from a parametric study to optimize these parameters are presented. To validate CFD nozzle flow predictions and to rule out potential for false results due to cavitation, laboratory tests were performed under pressurized conditions. A comparison of results from CFD simulations using traditional versus optimized parameters are presented, demonstrating significant efficiency improvement achieved. The study initially focused on North Sea application. Encouraged by substantial improvement in process efficiency through parametric optimization, the technique was extended to UK operations and is planned for the Bayu-Undan field. Cementing simulation results for Bayu-Undan specific well configurations are presented, showing how CFD modeling helped reveal less than ideal cementing efficiency. Ultimately, this work provides significant time savings and quality improvement for P&amp;A projects while maintaining a high safety standard.
Tissue Microscopy and Spectroscopy: A Two-Photon Approach (1998)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text B. R. Masters, P. T. C. So, W. Mantulin, and E. Gratton, "Tissue Microscopy and Spectroscopy: A Two-Photon Approach," in Advances in Optical Imaging and Photon Migration, J. Fujimoto and M. Patterson, eds., Vol. 21 of OSA Trends in Optics and Photonics (Optica Publishing Group, 1998), paper JMA4. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Mossbauer analysis of bauxite and synthetic bauxitic iron minerals (2021)

This thesis was scanned from the print manuscript for digital preservation and is copyright the author. Researchers can access this thesis by asking their local university, institution or public library to make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.
Abnormal Screening Echocardiogram in High-Risk Obese Pregnant Women Increases the Risk of Preeclampsia [20G] (2019)

INTRODUCTION: Obese women with comorbidities such as hypertension (HTN) and diabetes (DM) are at increased risk for preeclampsia (PreE) and perinatal morbidity. This study explores whether screening echocardiogram can identify obese women at higher risk for preeclampsia. METHODS: IRB-approved retrospective cohort study of women with BMI ≥40 kg/m 2 and one or more risk factor for PreE (diabetes, hypertension, rheumatologic disease) undergoing screening echocardiogram. Abnormal findings were defined as diastolic dysfunction, ejection fraction ≤ 40%, or enlargement of any heart cavity including left ventricle hypertrophy. Multinomial and multivariable logistic regression was used to estimate the relative risk (RR) of gestational hypertension (ghtn), PreE, or severe PreE, and preterm delivery &lt;37 weeks when controlling for potential confounders. RESULTS: Of 225 eligible women, 158 underwent screening echocardiograms. 39.9% (63/158) had abnormal echocardiograms. Clinical characteristics were similar between groups. Gestational age at time of echocardiogram was later (26.2 vs 21.5 wks P=0.0001) for women with abnormal echocardiograms, and women with abnormal echocardiogram were more likely to have chronic hypertension (79% vs 60%, P=0.02) and history of preeclampsia (28% vs 11%, P=0.03). After controlling for chronic HTN, history PreE, race, age, BMI, and GA at echo, women with abnormal echocardiogram were at increased risk of ghtn/PreE, 13% vs. 9%, aRR 4.87 (95% CI 1.36-17.53, P=0.02), severe PreE 54% vs. 15%, aRR 8.14 (95% CI 3.26-20.28, P=0.0001), and preterm delivery, 38% vs. 20%, aRR 4.87 (95% CI 1.36-17.53, P=0.02). CONCLUSION: Among obese pregnant women with vascular comorbidities, screening echocardiogram helps identify women at highest risk for developing preeclampsia.
Role of Long-Range Repulsive Interactions in Two-Dimensional Colloidal Aggregation:  Experiments and Simulations (2002)

A theoretical model for the interaction between colloidal particles trapped at the air−water interface is proposed in order to explain experimental aggregation results. Kinetic and structural aspects of 2D aggregation processes point out the long-range nature of the particle interactions. These interactions have been modeled by means of monopolar and dipolar repulsive forces, which depend on the monopole and dipole surface fractions at the emergent part of the colloidal particles, fmon and fdip, respectively. Brownian dynamics simulations have been used to fit the model to experiment results using the fractal dimension df and the kinetics exponent z as comparative parameters. Simulation results show that dipolar interaction controls aggregation at high subphase salt concentration whereas the monopolar interaction determines aggregation at low salt concentrations. Moreover, results show that fmon is the main parameter controlling kinetics in 2D aggregation and, hence, a critical coagulation concentration (CCC) can be defined from the salt concentration at which the monopole fraction becomes zero, fmon = 0.
Effets du calcium extracellulaire sur la mise en place du processus de différenciation kératinocytaire. Etude comparative entre des kératinocytes normaux humains et la lignée cellulaire HaCaT (2009)

Nous avons effectue une etude comparative entre des keratinocytes normaux humains (KNHs) et la lignee cellulaire HaCaT, issue de keratinocytes humains spontanement immortalises. L’objectif de ce travail a ete de comparer in vitro le passage d’un etat proliferatif vers un etat differencie. La differenciation a ete induite en augmentant la concentration en calcium (Ca2+) du milieu de culture a 1,2 mM. Nous avons mis en evidence que le Ca2+ entraine une proliferation plus importante des cellules HaCaT. Les changements morphologiques engendres par le Ca2+, specifiques du processus de differenciation keratinocytaire in vitro, apparaissent plus rapidement et de facon plus prononcee sur les KNHs. Independamment de la concentration en Ca2+, les KNHs sont majoritairement en phases G0-G1, tandis que les cellules HaCaT cultivees en presence de Ca2+ sont en phases S/G2-M, resultat en accord avec leur taux de proliferation plus important dans ces conditions. Comparativement aux KNHs, le Ca2+ induit plus tardivement l’expression de marqueurs de differenciation et de genes impliques dans le metabolisme lipidique dans les cellules HaCaT. Des differences ont egalement ete constatees dans l’expression des isoformes PPARs entre ces deux types cellulaires. En effet, la lignee HaCaT presente un profil d’expression des PPARs comparable a celui observe dans un epiderme psoriasique. Cependant, comme les KNHs, la lignee HaCaT, a conserve la capacite a induire l’expression de marqueurs de differenciation avec la confluence. Afin de comprendre pourquoi les cellules HaCaT proliferent plus rapidement en presence de Ca2+, des experimentations de tri par fractionnement flux-force ont mis en evidence qu’a partir d’un « pool total » de cellules HaCaT cultivees en presence de 1,2 mM de Ca2+, 10% semblent presenter des caracteristiques de cellules differenciees, notamment un taux de proliferation tres faible accompagne de l’augmentation de l’expression genique de marqueurs de differenciation. Nous avons donc montre que la lignee HaCaT presente une sensibilite moindre a l’induction de la differenciation keratinocytaire in vitro par le Ca2+, comparativement aux KNHs. Neanmoins, cette lignee conserve des caracteristiques typiques de la mise en place du processus de differenciation, telle que l’augmentation de l’expression de marqueurs de differenciation.
Targeting microbial pathogens (2018)

Plants secrete extracellular vesicles to prevent fungal infection
Heavy-metal fractionation and distribution in soil profiles short-term-irrigated with sewage wastewater (2006)

Six soil profiles irrigated and non-irrigated with sewage wastewater were investigated for soil pH, electrical conductivity (EC), organic matter (OM), and CaCO3. The distributions and chemical fractions of Cu, Zn, Cd, and Pb, and their lability were also studied. The results indicated that pH, EC, OM, and CaCO3, as well as metal fractionation in soil profiles were affected by wastewater irrigation, especially in the surface layer. The surface layer (0–15 cm) irrigated with wastewater exhibited a 0.6 unit decrease in soil pH, a 40.6% decrease in CaCO3, and a 200% increase in EC as compared with that of the non-irrigated soil. The soil OM increased from 0.04% to 0.35% in the surface layer. The irrigation of soil with wastewater resulted in transformation of metals from the carbonate fraction (CARB) towards the exchangeable (EXCH), Fe–Mn oxide (ERO), and organic (OM) fraction for Zn, towards the EXCH, the OM, and residual fraction for Cu, and towards the exchangeable (EXCH) fraction for Cd. It was concluded that the use of sewage wastewater led to salt accumulation and an increase in the readily labile fraction of Zn, Cu, and Cd in the surface layer. Therefore, this reason may limit the use of wastewater under arid and semi-arid conditions.
Mitochondrial dysfunction and tau hyperphosphorylation in Ts1Cje, a mouse model for Down syndrome (2006)

Trisomy 21 or Down syndrome (DS) is the most common genetic birth defect associated with mental retardation. The over-expression of genes on chromosome 21, including SOD1 (Cu/Zn superoxide dismutase) and APP (amyloid-beta precursor protein) is believed to underlie the increased oxidative stress and neurodegeneration commonly described in DS. However, a segmental trisomy 16 mouse model for DS, Ts1Cje, has a subset of triplicated human chromosome 21 gene orthologs that exclude APP and SOD1. Here, we report that Ts1Cje brain shows decreases of mitochondrial membrane potential and ATP production, increases of reactive oxygen species, hyperphosphorylation of tau without NFT formation, increase of GSK3beta and JNK/SAPK activities and unaltered AbetaPP metabolism. Our findings suggest that genes on the trisomic Ts1Cje segment other than APP and SOD1 can cause oxidative stress, mitochondrial dysfunction and hyperphosphorylation of tau, all of which may play critical roles in the pathogenesis of mental retardation in DS.
Two-axis quantum control of a fast valley qubit in silicon (2019)

Abstract Quantum dots in silicon are a promising architecture for semiconductor quantum computing due to a high degree of electric control and compatibility with existing silicon fabrication processes. Although electron charge and spin are prominent methods for encoding the qubit state, valley states in silicon can also store quantum information via valley-orbit coupling with protection against charge noise. By observing coherent oscillations between valley states in a Si/SiGe double quantum dot device tuned to the two-electron charge configuration, we measure the valley energy splitting in both quantum dots individually. We further demonstrate two-axis quantum control of the valley qubit using gated pulse sequences with X and Z rotations occurring within a fast operation time of 300 ps. This control is used to completely map out the surface of the Bloch sphere in a single phase-space plot that is subsequently used for state and process tomography.
The effect of indomethacin on cardiovascular and lysosomal mechanisms during experimental myocardial ischemia. (1978)

The present study evaluated the effects of indomethacin (INDO) on cardiovascular and lysosomal mechanisms during experimental myocardial ischemia (MI). INDO (5 mg/kg) was infused IV prior to MI, and the results were compared to vehicle-treated and sham-operated dogs. INDO induced a slight hypertension after MI. Additionally, INDO attenuated the decline in coronary blood flow in the non-ischemic myocardium after MI. Myocardial lysosomes (biopsied three hours post-MI) were more labile in ischemic than in nonischemic tissue, and INDO had a stabilizing effect on lysosomes from ischemic tissue. Plasma activity of cathepsin was increased following MI, and INDO attenuated this increase. In the myocardium (biopsies three hours post-MI) prostaglandin A + E levels were suppressed 60% in both ischemic and nonischemic tissue with INDO treatment; prostaglandin F2 alpha levels were lower with INDO treatment but not significantly so. These results suggest that INDO has a stabilizing effect on lysosomes in vivo, possibly involving an endogenous prostaglandin mechanism, and this protective effect may attenuate lysosomal damage to the cardiovascular system during MI.
TWEAK/Fn14 Interactions Are Instrumental in the Pathogenesis of Nephritis in the Chronic Graft-versus-Host Model of Systemic Lupus erythematosus (2007)

TNF-like weak inducer of apoptosis (TWEAK), a member of the TNF superfamily, is a prominent inducer of proinflammatory cytokines in vitro and in vivo. We previously found that kidney cells display the TWEAK receptor Fn14, and that TWEAK stimulation of mesangial cells and podocytes induces a potent proinflammatory response. Several of the cytokines up-regulated in the kidney in response to TWEAK are instrumental in Lupus nephritis; we therefore hypothesized that TWEAK/Fn14 interactions may be important in the cascade(s) leading to renal damage in systemic Lupus erythematosus. In this study, we analyzed the effects of Fn14 deficiency in the chronic graft-vs-host model of SLE, and the benefits of treatment with an anti-TWEAK mAb in this mouse model. We found that anti-nuclear Ab titers were no different between C57BL/6 Fn14 wild-type and deficient mice injected with alloreactive bm12 splenocytes. However, kidney disease was significantly less severe in Fn14 knockout mice. Furthermore, kidney IgG deposition, IL-6, MCP-1, RANTES, and IP-10, as well as macrophage infiltration, were significantly decreased in Fn14-deficient mice with induced lupus. Similarly, mice with induced Lupus treated with an anti-TWEAK neutralizing mAb had significantly diminished kidney expression of IL-6, MCP-1, IL-10, as well as proteinuria, but similar autoantibody titers, as compared with control-treated mice. We conclude that TWEAK is an important mediator of kidney damage that acts by promoting local inflammatory events, but without impacting adaptive immunity in this experimental LN model. Thus, TWEAK blockade may be a novel therapeutic approach to reduce renal damage in SLE.
Substrate specificity of the pyrophosphohydrolase LpxH determines the asymmetry of Bordetella pertussis lipid A (2019)

Lipopolysaccharides are anchored to the outer membrane of Gram-negative bacteria by a hydrophobic moiety known as lipid A, which potently activates the host innate immune response. Lipid A of <i>Bordetella pertussis</i>, the causative agent of whooping cough, displays unusual structural asymmetry with respect to the length of the acyl chains at the 3 and 3' positions, which are 3OH-C10 and 3OH-C14 chains, respectively. Both chains are attached by the acyltransferase LpxA, the first enzyme in the lipid A biosynthesis pathway, which, in <i>B. pertussis</i>, has limited chain length specificity. However, this only partially explains the strict asymmetry of lipid A. In attempts to modulate the endotoxicity of <i>B. pertussis</i> lipid A, here we expressed the gene encoding LpxA from <i>Neisseria meningitidis</i>, which specifically attaches 3OH-C12 chains, in <i>B. pertussis</i> This expression was lethal, suggesting that one of the downstream enzymes in the lipid A biosynthesis pathway in <i>B. pertussis</i> cannot handle precursors with a 3OH-C12 chain. We considered that the UDP-diacylglucosamine pyrophosphohydrolase LpxH could be responsible for this defect as well as for the asymmetry of <i>B. pertussis</i> lipid A. Expression of meningococcal LpxH in <i>B. pertussis</i> indeed resulted in new symmetric lipid A species with 3OH-C10 or 3OH-C14 chains at both the 3 and 3' positions, as revealed by MS analysis. Furthermore, co-expression of meningococcal <i>lpxH</i> and <i>lpxA</i> resulted in viable cells that incorporated 3OH-C12 chains in <i>B. pertussis</i> lipid A. We conclude that the asymmetry of <i>B. pertussis</i> lipid A is determined by the acyl chain length specificity of LpxH.
Erratum to: Impact Of Sex On Clinical Characteristics And In-Hospital Outcomes In A Multi-Ethnic Southeast Asian Population Of Patients Hospitalized For Acute Heart Failure (2014)

Unfortunately, some tables and figures were missing in the original version. The missing tables and figures are presented below.
LEADS: an interactive research oriented ECG/VCG analysis system (2005)

We recently developed a MATLAB program, LEADS (Leiden ECG analysis and decomposition software), for research oriented ECG/VCG analysis. Any eight-channel recording in comma-separated values format (CSV) can be input. After detection of QRST complexes in the spatial velocity signal and baseline correction, LEADS generates a default selection of beats for subsequent averaging. The analyst may then adjust this selection, after which the selected beats are averaged to generate a representative and low-noise averaged beat (ECG and VCG). In this beat, LEADS computes default onset-QRS, end-QRS and end-T instants, which may be subsequently reviewed/edited. Finally, several conventional and advanced ECG and VCG parameters are automatically computed, and the results are output in the form of a CSV file. By virtue of the combination of adjustable configuration settings and interactive procedures, LEADS has provided us with the ability to reliably analyze ECGs ranging from normal to highly pathological
Corrigendum to: 'Guidelines for the diagnosis and treatment of pulmonary hypertension' [European Heart Journal (2009) 30, 2493-2537]. The Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT) (2011)

The 2009 ESC Practice Clinical Guidelines for the diagnosis and treatment of pulmonary hypertension included the endothelin receptor antagonist sitaxentan in an algorithm of evidence-based treatment for pulmonary arterial hypertension. Sitaxentan was recommended with a Class I/Level A grade of evidence in WHO functional class III patients and Class IIa/Level C grade of evidence in WHO functional clsses II and IV.

Sitaxentan was initially authorized by …
MTG8 interacts with LHX6 to specify cortical interneuron subtype identity (2022)

Cortical interneurons originating in the embryonic medial ganglionic eminence (MGE) diverge into a range of different subtypes found in the adult mouse cerebral cortex. The mechanisms underlying this divergence and the timing when subtype identity is set up remain unclear. We identify the highly conserved transcriptional co-factor MTG8 as being pivotal in the development of a large subset of MGE cortical interneurons that co-expresses Somatostatin (SST) and Neuropeptide Y (NPY). MTG8 interacts with the pan-MGE transcription factor LHX6 and together the two factors are sufficient to promote expression of critical cortical interneuron subtype identity genes. The SST-NPY cortical interneuron fate is initiated early, well before interneurons migrate into the cortex, demonstrating an early onset specification program. Our findings suggest that transcriptional co-factors and modifiers of generic lineage specification programs may hold the key to the emergence of cortical interneuron heterogeneity from the embryonic telencephalic germinal zones.