gebhart/patrepeval huggingface dataset:
Peroxisome proliferator-activated receptor-γ stimulates the synthesis of monounsaturated fatty acids in dairy goat mammary epithelial cells via the control of stearoyl-coenzyme A desaturase (2013)

In rodents, peroxisome proliferator-activated receptor-γ (PPARG) plays a crucial role in fatty acid (FA) metabolism through regulation of gene expression, including stearoyl-coenzyme A desaturase (SCD), which is the rate-limiting enzyme for the biosynthesis of monounsaturated FA. However, whether or how PPARG regulates the activity of mammary SCD in ruminants is unknown. This study explored the potential role of PPARG isoforms in regulating SCD mRNA expression in lactating goat mammary epithelial cells (GMEC). Using quantitative real-time PCR, we observed a positive correlation between PPARG and SCD expression in the goat mammary gland at peak lactation. Overexpression of both PPARG1 and PPARG2 in GMEC increased markedly the expression of SCD, the concentration of 16:1 and 18:1, and the desaturation indices of 16:1 and 18:1. The PPARG ligand rosiglitazone further increased SCD expression and desaturation indices in GMEC, overexpressing PPARG1 and PPARG2. Incubation with rosiglitazone alone increased the expression of SCD, but did not alter the concentration of 16- to 18-carbon FA or their desaturation indices. The results provide evidence that PPARG regulates the expression and activity of SCD in GMEC. As such, PPARG may contribute to regulation of SCD and monounsaturated FA synthesis during lactation.
ChemInform Abstract: Atomic Fluorine Anion Storage Emission Material C12A7‐F‐ and Etching of Si and SiO2 by Atomic Fluorine Anions. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The Effect of Curing Temperature and Time on the Acoustic and Optical Properties of PVCP (2019)

Polyvinyl chloride plastisol (PVCP) has been increasingly used as a phantom material for photoacoustic and ultrasound imaging. As one of the most useful polymeric materials for industrial applications, its mechanical properties and behavior are well-known. Although the acoustic and optical properties of several formulations have previously been investigated, it is still unknown how these are affected by varying the fabrication method. Here, an improved and straightforward fabrication method is presented, and the effect of curing temperature and curing time on the PVCP acoustic and optical properties, as well as their stability over time, is investigated. The speed of sound and attenuation were determined over a frequency range from 2 to 15 MHz, while the optical attenuation spectra of samples were measured over a wavelength range from 500 to 2200 nm. The results indicate that the optimum properties are achieved at curing temperatures between 160 °C and 180 °C, while the required curing time decreases with increasing temperature. The properties of the fabricated phantoms were highly repeatable, meaning that the phantoms are not sensitive to the manufacturing conditions provided that the curing temperature and time are within the range of complete gelation-fusion (samples are optically clear) and below the limit of thermal degradation (indicated by the yellowish appearance of the sample). The samples' long-term stability was assessed over 16 weeks, and no significant change was observed in the measured acoustic and optical properties.
Complete genomic characterization of a murine papillomavirus isolated from papillomatous lesions of a European harvest mouse (Micromys minutus) (2007)

The papillomaviruses form a large group of species-specific pathogens that cause epithelial proliferations in a wide spectrum of animal hosts. Previous reports demonstrated a relatively high frequency of a variety of skin lesions in captive European harvest mice. The Micromys minutus papillomavirus (MmPV) was isolated from one of these lesions found on a captive European harvest mouse in a regional zoo in Chicago. In this study we present the entire genomic sequence of MmPV. The MmPV genome is organized into the seven classical papillomaviral open reading frames. Phylogenetic analysis places MmPV together with a papillomavirus (PV) isolated from a Syrian golden Hamster (HaOPV) in the genus Pipapillomavirus. The similar clustering pattern of the MmPV-HaOPV pair and their rodent hosts support the hypothesis of papillomaviral and host co-phylogenetic descent. The availability of the complete genomic sequence of a mouse PV should allow researchers to use MmPV as a model for PV carcinogenesis.
Pressure Effect on the Homogeneity of Spark Plasma‐Sintered Tungsten Carbide Powder (2009)

A combined experimental/numerical methodology was developed to aid full densification of pure ultrafine tungsten carbide powder by means of Spark Plasma Sintering (SPS) operating in Current Control mode. Applied pressure ranged from 5 to 80 MPa while the current intensity was set and held constant at 1400 A. The developed SPS model used a moving‐mesh technique to account for the electrothermal contact resistance change during both shrinkage and punch sliding follow‐up. The pressure dependence on the electrothermal contact resistance was also taken into account by the model. The experimental and numerical results showed the effects of pressure on grain growth, residual porosity, and hardness observed along the sample radius. Upon increasing sintering pressure, complete densification was obtained by reducing the peak temperature measured at the die surface. By combining experimental and modeling results, a direct correlation between compact microstructure homogeneity and sintering parameters (i.e., temperature and applied pressure) was established.
Resistance movements: combatting infection risk in veterinary practice through visualisation method (2019)

Antimicrobial-resistant (AMR) bacteria are an established and growing issue in companion animal veterinary practice in the developed and developing world. Effective infection prevention control measures (ICMs) are essential for tackling the AMR problem to reduce antibiotic use. The uptake of appropriate ICM is heavily influenced by human risk perception and consequent behaviour and the way humans and animals interact with the physical environment of the veterinary practice. Effective communication and teaching tools are therefore necessary to ensure the understanding and behaviours of the broad range of individuals (clinical and non-clinical) comprising the team are in line with scientific recommendations. Whilst data exist to inform best practise in ICM, they are normally published in academic journals, thus having limited impact on how practitioners understand and practise ICM in their working environment. Innovative ways of communicating risks to practitioners in this context are therefore required. The research team’s ambition is to change the perception – in veterinary staff - of the risk of infection, leading to a reduced risk of bacterial contamination and infection, and ultimately reduced reliance on antibiotics. &#13;\nThe researchers’ approach is to ‘make visible the invisible' through the building of a three-dimensional graphical simulation tool (AMRSim: A Microbial Reality Simulator) showing the interior of a veterinary practice in which humans, animals, and microorganisms (bacteria in this study) interact, according to rules observed from real-life. This will be used to support an intervention, a training session with veterinary practice staff to encourage effective reflective behavioural changes that positively impact on microbial contamination, thereby reducing the risk of the development, acquisition and transmission of harmful bacteria.
Waste Form Release Calculations for the 2001 Immobilized Low-Activity Waste Performance Assessment (2001)

A set of reactive chemical transport calculations was conducted with the Subsurface Trans-port Over Reactive Multiphases (STORM) code to evaluate the long-term performance of a representative low-activity waste glass in a shallow subsurface disposal system located on the Hanford Site. 1-D simulations were conducted out to times in excess of 20,000 y. A 2-D simulation was run to 2,000 y. The maximum normalized, decay-corrected Tc release rate from a trench type conceptual design under a constant recharge rate of 4.2 mm/y is 0.76 ppm/y. Factors that were found to significantly impact the predicted release rate were water recharge rate, chemical affinity control of glass dissolution rate, diffusion coefficient, and disposal system design (trench versus a concrete-lined vault). In contrast, corrosion of the steel pour canister surrounding the glass waste, and incorporation of chemical conditioning layer of silica sand at the top of the trench had little impact on Tc release rate.
Investigation of Unsteady Flow Field in a Vaned Diffuser of a Transonic Centrifugal Compressor (2006)

Transonic centrifugal compressors are used with high-load turbochargers and turboshaft engines. These compressors usually have a vaned diffuser to increase the efficiency and the pressure ratio. To improve the performance of such a centrifugal compressor, it is required to optimize not only the impeller but also the diffuser. However the flow field of the diffuser is quite complex and unsteady because of the impeller located upstream. Although some research on vaned diffusers has been published, the diffuser flow is strongly dependent on the particular impeller exit flow, and some of the flow physics remain to be elucidated. In the research reported here, detailed flow measurements within a vaned diffuser were conducted using a particle image velocimetery (PIV). The vaned diffuser was designed with high subsonic inlet conditions marked by an inlet Mach number of 0.95 for the transonic compressor. As a result, a complex three-dimensional flow with distortion between the shroud and the hub was observed. Also, unsteady flow accompanying the inflow of the impeller wake was confirmed. Steady computational flow analysis was performed and compared with the experimental results.
Application of narrow-bore HPLC columns in rapid determination of sildenafil citrate in its pharmaceutical dosage forms. (2012)

A special type of silica-based columns has been recently introduced into the market which is called narrow-bore columns. They have lower internal volume than the standard high-performance liquid chromatography (HPLC) columns and thus reduce the solvent consumption by almost 80%. A simple, accurate and environmentally friendly reversed phase- HPLC (RP-HPLC method) which could be used in fast and high throughput analyses has been developed for the purpose of determining the sildenafil in bulk and pharmaceutical dosage forms, using narrow-bore C18 column (50 × 3.2 mm, 5 µm particle size) in isocratic mode, with mobile phase comprising of buffer (pH = 3) and acetonitrile in the ratio of 75:25 v/v. The flow rate was 0.7 mL/min and the detection was monitored through Ultraviolet detector (UV detector) at 292 nm. Clonazepam was used as the internal standard and the run time was 4 min. The proposed method has permitted the quantification of sildenafil over the linearity in the range of 30-4000 ng/mL and its percentage recovery was found to be 99-105%. Limit of quantitation (LOQ) is determined as 30 ng/mL. The intra-day and inter-day precisions were found 1.2-2.2% and 1.56-3.4% respectively. The solvent consumption was 2.8 mL per sample of which ca 0.7 mL was acetonitrile. This study shows that the application of narrow-bore column instead of the conventional reversed phase column in HPLC analyses has the advantages of shorter run time and less organic solvent consumption. This method is highly sensitive with excellent recoveries and precision and there is no need for special column and pre-column or post-column treatment of the sample. Moreover, the method is free from interference by common additives and excipients, suggesting applications in routine quality control analyses.
Supplementary Table 1 from Global Gene Expression Profiling of Circulating Endothelial Cells in Patients with Metastatic Carcinomas (2023)

Supplementary Table 1 from Global Gene Expression Profiling of Circulating Endothelial Cells in Patients with Metastatic Carcinomas
Diagnostic Tools for Measuring Early Chemical Signatures of Algae Pond Crash. (2018)

Abstract not provided.
Sourdough: a tool for the improved flavour, texture and shelf-life of wheat bread (2005)

3 Academic dissertation 5 Preface 7 List of original publications 8 List of symbols 11
Place and causes of acute cardiovascular mortality during the COVID-19 pandemic (2020)

The COVID-19 pandemic has resulted in an inflation in acute cardiovascular deaths, nearly half of which occurred in the community and most did not relate to COVID-19 infection suggesting there were delays to seeking help or likely the result of undiagnosed COVID-19.
Multicasting layered multimedia streams in an ATM environment (2002)

HMC (Heterogeneous MultiCast) is a communication paradigm which uses the technique of partitioning data streams into a hierarchy of layers (one base layer and several enhancement layers) and allows each receiver in a multicast connection to subscribe to a different number of layers, based on the available resources and preferences. This paper describes an implementation of HMC over ATM networks. UNI signaling is used as the basic mechanism to create and delete VCs which carry each layer of a hierarchically encoded stream. However, UNI signaling does not provide any means to group the VCs carrying related data from different layers of a particular stream. Grouping of layers is important from an application's perspective because it expects to receive layers in order (base layer and then the first enhancement layer and so on). One approach to solve this problem is to add intelligence to all the network switches so that they can understand the hierarchy of layers and thus make informed decisions about routing and resource allocation. However, this approach requires changing the switching software throughout the network and hence is not portable. The scheme described in this paper utilizes the existing ATM UNI signaling (which does not have any provision for carrying layered streams) and adds some end-to-end functionality to transport layered streams though a network.
Neisseria gonorrhoeae vaccine development: hope on the horizon? (2018)

As antibiotic resistance continues to increase, vaccine development for N. gonorrhoeae becomes more urgent. The MeNZB vaccine is shown to have efficacy, albeit relatively low, against N. gonorrhoeae. This finding has the potential to reinvigorate research in the field of gonococcal vaccine development and will guide future studies of the antigens and mechanism(s) required for protection against gonococcal infection.
A Highly Enantio‐ and Diastereoselective Cu‐Catalyzed 1,3‐Dipolar Cycloaddition of Azomethine Ylides with Nitroalkenes (2006)

Electronic properties of the ligands switch the diastereoselectivity in the Cu-catalyzed 1,3-dipolar cycloaddition of azomethine ylides to nitroalkenes: exo- or endo-pyrrolidines were obtained with high diastereo- and enantioselectivities in the presence of different chiral (phosphanylferrocenyl)oxazoline ligands (e.g. 3 a, b).
PC-based control of robotic and mechatronic systems under MS-Windows NT workstation (2001)

A method is proposed to perform control using Intel/sup (R)/ based PCs operated by Windows NT/sup TM/ directly. The software package developed is called WinRec v.1 (Windows real-time control). This low cost method keeps all the advantages of Windows NT without attaching any other kernels and avoids switching different operating systems between experimentation and control design/analysis. A thorough description of the method to set up the multimedia timer provided by Microsoft Development Network Library is presented. Self-customized algorithms based on advanced control techniques can be implemented with the standard protocol that is established here. The proposed protocol is evaluated using two different systems in control experiments. In the first system, an industrial robot manipulator is controlled by applying an independent joint PID control scheme. Results are also shown from experiments where LQR and H/sub 2/ controllers are applied to suppress vibrations of a flexible payload carried by the robot manipulator. In the second system, position, force, temperature, voltage and current data are simultaneously recorded in order to evaluate the performance of a shape-memory-alloy wire bundle actuator in open loop control experiments.
Paper 16: Risk Factors for Stress Fractures, Orthopaedic Acute and Overuse Injuries in Female Infantry Recruits (2012)

5-30% of infantry recruits suffer stress fractures. 20% suffer ankle sprains and approximately 30% suffer anterior knee pain. In this study we followed up a group of female infantry recruits in order to define the risk factors for acute and overuse injures.
Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study (2022)

In the present international cohort, the most frequently used advanced respiratory support was the HFNC. However, IMV was used more often in LMIC. Higher leucocyte count, tachypnoea, and treatment in LMIC were risk factors for HFNC/NIV failure. HFNC/NIV failure was related to worse clinical outcomes, such as 28-day mortality. Trial registration This is a prospective observational study; therefore, no health care interventions were applied to participants, and trial registration is not applicable.
Doping Approaches for Organic Semiconductors (2021)

Electronic doping in organic materials has remained an elusive concept for several decades. It drew considerable attention in the early days in the quest for organic materials with high electrical conductivity, paving the way for the pioneering work on pristine organic semiconductors (OSCs) and their eventual use in a plethora of applications. Despite this early trend, however, recent strides in the field of organic electronics have been made hand in hand with the development and use of dopants to the point that are now ubiquitous. Here, we give an overview of all important advances in the area of doping of organic semiconductors and their applications. We first review the relevant literature with particular focus on the physical processes involved, discussing established mechanisms but also newly proposed theories. We then continue with a comprehensive summary of the most widely studied dopants to date, placing particular emphasis on the chemical strategies toward the synthesis of molecules with improved functionality. The processing routes toward doped organic films and the important doping-processing-nanostructure relationships, are also discussed. We conclude the review by highlighting how doping can enhance the operating characteristics of various organic devices.
Quantum-Dot-Based Advanced Photonic Devices and Its Applications (2017)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text A. Matsumoto, K. Akahane, T. Umezawa, T. Kita, K. Utaka, and N. Yamamoto, "Quantum-Dot-Based Advanced Photonic Devices and Its Applications," in Asia Communications and Photonics Conference, OSA Technical Digest (online) (Optica Publishing Group, 2017), paper M1D.6. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Sodium Selenite Increases the Activity of the Tumor Suppressor Protein, PTEN, in DU-145 Prostate Cancer Cells (2009)

Epidemiological and clinical data suggest that selenium may prevent prostate cancer; however, the cellular effects of selenium in malignant prostate cells are not well understood. We previously reported that the activity of the tumor suppressor PTEN is modulated by thioredoxin (Trx) in a RedOx-dependent manner. In this study, we demonstrated that the activity of Trx reductase (TR) is increased by sevenfold in the human prostate cancer cell line, DU-145, after 5 days of sodium selenite (Se) treatment. The treatment of DU-145 cells with increasing concentrations of Se induced an increase in PTEN lipid phosphatase activity by twofold, which correlated with a decrease in phospho-ser(473)-Akt, and an increase in phospho-Ser(370)-PTEN levels. Se also increased casein kinase-2 (CK2) activity; and the use of apigenin, an inhibitor of CK2, revealed that the regulation of the tumor suppressor PTEN by Se may be achieved via both the Trx-TR system and the RedOx control of the kinase involved in the regulation of PTEN activity.
Efficient hierarchical matching algorithm for processing uncalibrated stereo vision images and its hardware architecture (2011)

In motion estimation, the sub-pixel matching technique involves the search of sub-sample positions as well as integer-sample positions between the image pairs, choosing the one that gives the best match. Based on this idea, this work proposes an estimation algorithm, which performs a 2-D correspondence search using a hierarchical search pattern. The intermediate results are refined by 3-D cellular automata (CA). The disparity value is then defined using the distance of the matching position. Therefore the proposed algorithm can process uncalibrated and non-rectified stereo image pairs, maintaining the computational load within reasonable levels. Additionally, a hardware architecture of the algorithm is deployed. Its performance has been evaluated on both synthetic and real self-captured image sets. Its attributes, make the proposed method suitable for autonomous outdoor robotic applications.
Lactic acid bacteria of the sour cassava starch fermentation (1995)

Journal Article Lactic acid bacteria of the sour cassava starch fermentation Get access C. Figueroa, C. Figueroa Laboratoire de Microbiologie, Institut National Agronomique Paris‐Grignon, Paris, France Search for other works by this author on: Oxford Academic Google Scholar A.M. Davila, A.M. Davila Laboratoire de Microbiologie, Institut National Agronomique Paris‐Grignon, Paris, France Search for other works by this author on: Oxford Academic Google Scholar J. Pourquié J. Pourquié Laboratoire de Microbiologie, Institut National Agronomique Paris‐Grignon, Paris, France Professor Jacques Pourquié, Chaire de Microbiologie, Institut National Agronomique Paris‐Grignon, 16 rue Claude Bernard, 75231 Paris Cedex 05, Frace. Search for other works by this author on: Oxford Academic Google Scholar Letters in Applied Microbiology, Volume 21, Issue 2, 1 August 1995, Pages 126–130, https://doi.org/10.1111/j.1472-765X.1995.tb01023.x Published: 01 August 1995 Article history Received: 17 March 1995 Accepted: 21 March 1995 Published: 01 August 1995
Simple Synthesis of Elastomeric Photomechanical Switches That Self‐Heal (2019)

Front Cover: Photomechanical polymeric materials could be the future for building light-driven soft robotic actuators. In article number 1800815, Robert F. Shepherd and co-workers propose a simple synthesis and processing route for the fabrication of a self-healing photomechanical elastomer. This material enables the construction of complex 3D shapes using a simple ‘cut and paste’ assembly.