gebhart/patrepeval huggingface dataset:
Role of the N-terminal Proline Residue in the Catalytic Activities of the Escherichia coli Fpg Protein (2000)

The Escherichia coli Fpg protein is a DNA glycosylase/AP lyase. It removes, in DNA, oxidized purine residues, including the highly mutagenic C8-oxo-guanine (8-oxoG). The catalytic mechanism is believed to involve the formation of a transient Schiff base intermediate formed between DNA containing an oxidized residue and the N-terminal proline of the Fpg protein. The importance and the role of this proline upon the various catalytic activities of the Fpg protein was examined by targeted mutagenesis, resulting in the construction of three mutant Fpg proteins: Pro-2 --> Gly (FpgP2G), Pro-2 --> Thr (FpgP2T), and Pro-2 --> Glu (FpgP2E). The formamidopyrimidine DNA glycosylase activities of FpgP2G and FpgP2T were comparable and accounted for 10% of the wild-type activity. FpgP2G and FpgP2T had barely detectable 8-oxoG-DNA glycosylase activity and produced minute Schiff base complex with 8-oxoG/C DNA. FpgP2G and FpgP2T mutants did not cleave a DNA containing preformed AP site but readily produced Schiff base complex with this substrate. FpgP2E was completely inactive in all the assays. The binding constants of the different mutants when challenged with a duplex DNA containing a tetrahydrofuran residue were comparable. The mutant Fpg proteins barely or did not complement in vivo the spontaneous transitions G/C --> T/A in E. coli BH990 (fpg mutY) cells. These results show the mandatory role of N-terminal proline in the 8-oxoG-DNA glycosylase activity of the Fpg protein in vitro and in vivo as well as in its AP lyase activity upon preformed AP site but less in the 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine-DNA glycosylase activity.
Convolutional Neural Network Based Radio Tomographic Imaging (2020)

Radio tomographic imaging (RTI) is a promising technology to reconstruct the attenuation caused by physical objects in wireless networks, which has shown potential for various applications (e.g., static structure estimation, through-wall imaging, device-free localization, intrusion detection). Unfortunately, since the inverse problem of radio tomography is often ill-posed, as well as the prior information of the tomographic model and imaging features is limited, traditional RTI methods cannot achieve high accuracy. In addition, most existing methods can only reconstruct the changes in the imaging area, or they require a separate model calibration step which may cause some mismatching error. In this paper, an uncalibrated RF sensor network with mobile nodes is used to gather RSS measurements. We analyze the forward model of radio tomography in detail, and propose a convolutional neural network (CNN) based deep learning method to solve the inverse problem. Two CNNs which have the same structure are designed to reconstruct the static tomographic images and estimate the model parameters, respectively. Besides, we present a CNN based image post-processing method to improve imaging quality further. Simulation results validate the efficacy of the proposed methods.
ChemInform Abstract: Phenylsulfonylethylidene (PSE) Acetals: A Novel Protective Group in Carbohydrate Chemistry. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Mixed Micelles Formed by Cationic Surfactants and Anionic Hydrophobically Modified Polyelectrolytes (1996)

ADVERTISEMENT RETURN TO ISSUEPREVCorrectionMixed Micelles Formed by Cationic Surfactants and Anionic Hydrophobically Modified PolyelectrolytesBenoît Magny, Ilias Iliopoulos, Raoul Zana, and Roland AudebertCite this: Langmuir 1996, 12, 10, 2616Publication Date (Web):May 15, 1996Publication History Published online15 May 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/la960235hhttps://doi.org/10.1021/la960235hcorrectionACS PublicationsCopyright © 1996 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views319Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (32 KB) Get e-AlertscloseSUBJECTS:Aggregation,Aromatic compounds,Micelles,Polyelectrolytes,Surfactants Get e-Alerts
Automatic Lung Cancer Detection and Classification in Whole-slide Histopathology (2020)

This is the challenge design document for the "Automatic Lung Cancer Detection and Classification in Whole-slide Histopathology" Challenge, accepted for MICCAI 2020. Digital pathology has been gradually introduced in clinical practice. Although the digital pathology scanner could<br> give very high resolution whole-slide images (WSI) (up to 160nm per pixel), the manual analysis of WSI is still a<br> time-consuming task for the pathologists. Automatic analysis algorithms offer a way to reduce the burden for<br> pathologists. Our proposed challenge will focus on automatic detection and classification of lung cancer using<br> Whole-slide Histopathology. This subject is highly clinical relevant because lung cancer is the top cause of cancerrelated<br> death in the world. The first stage of the challenge (ACDC2019) was already successfully held in 2019 in<br> ISBI (https://acdc-lunghp.grand-challenge.org/). ACDC2019 mainly focused on the detection of lung cancer region<br> in WSIs. ACDC2020 will focus on classifying the main lung cancer subtypes (e.g. squamous carcinoma,<br> adenocarcinoma) using WSI.
The Educational Activities of Jeong Keuk In in Taein Province and its Historical Significance (2013)

본 논문에서는 ‘상춘곡’의 저자로 널리 알려진 정극인(1401-1481)의 교육자로서의 삶과 교육관 및 교육실천에 대해 살펴보았다. 논문에서 고찰한 바에 따르면, 정극인은 1436년에 처향인 태인에 낙향한 이후 가숙(家塾)을 열어 인근의 자제들을 모아 가르쳤는데, 이것은 훗날 손제자격인 송세림(1479-?)에 의해 향학당(鄕學堂)으로 발전하였고, 1543년에 현감 신잠(1491-1554)이 부임한 이후 설립되는 5학당(五學堂)의 기반이 되기도 하였다. 아울러 정극인은 지역민들과 함께 조선조 최초의 향약이라 할 수 있는 고현동향약을 시행하고 향음주례를 거행하여 태인 지역을 유교적 공동체로 교화해 나가는 데 힘쓰기도 하였다. 50세 이후 성균관의 천거로 시작한 정극인의 관직 생활 중에서도 가장 비중이 컸던 것은 성균관과 종학의 주부와 박사, 전주부 교수, 태인현 훈도 등의 교관직이었다. 교육자로서의 그의 삶은 1472년(성종 3)에 고을의 자제들을 모아 교육에 힘쓴 공으로 3품 산관 중직대부를 더해 받는 것으로 세상의 인정을 받게 된다. 이처럼 교육자로서의 삶을 살았던 정극인이 갖고 있던 교육관은 그가 교수·훈도 시절 작성했다고 하는 과 50대에 자손들에게 남긴 를 통해 살펴 볼 수 있는데, 다분히 현실적이고 공리적(功利的)인 성격을 갖고 있기는 하지만, 학문의 중요성에 절실한 인식과 함께 교육자로서의 남다른 열정과 신념을 잘 보여주고 있다. 태인에서의 정극인의 교육활동은 이후 무성서원(武城書院)의 탄생 등 태인 지역의 교육 전통 형성에 선구적 역할을 하였다는 점 뿐만 아니라 명종 1년(1546) 반포를 전후로 한 조선전기 지방교육의 구체적 양상을 보여준다는 점에서도 중요한 역사적 의의를 갖고 있다.
Ultrasmall near-infrared gold nanoclusters for tumor fluorescence imaging in vivo (2010)

In this paper, we explore the possibility of using ultrasmall near-infrared (NIR) gold nanoclusters (AuNCs) as novel contrast imaging agents for tumor fluorescence imaging in vivo. The fluorescence imaging signal of the tail vein administrated AuNCs in living organisms can spectrally be well distinguished from the background with maximum emission wavelength at about 710 nm, and the high photostability of AuNCs promises continuous imaging in vivo. The uptake of AuNCs by the reticuloendothelial system is relatively low in comparison with other nanoparticle-based contrast imaging agents due to their ultrasmall hydrodynamic size (∼2.7 nm). Through the body weight change analysis, the results show that the body weight of the mice administrated with AuNCs has not been changed obviously in comparison with that of the control mice injected with PBS. Furthermore, using MDA-MB-45 and Hela tumor xenograft models, in vivo and ex vivo imaging studies show that the ultrasmall NIR AuNCs are able to be highly accumulated in the tumor areas, thanks to the enhanced permeability and retention (EPR) effects. And the tumor-to-background ratio is about 15 for 6 h postinjection. The results indicate that the ultrasmall NIR AuNCs appear as very promising contrast imaging agents for in vivo fluorescence tumor imaging.
High Serum Alpha-2-Macroglobulin Level in Patients with Osteonecrosis of the Femoral Head. (2018)

Our findings suggest that avascular necrotic femur head presumably directly or indirectly elevates A2M in the bloodstream. Thus, serum level of A2M might be used as a reliable diagnostic tool in clinical practice.
Creation of Thin Films of NbN at Room Temperature of the Substrate (2021)

Magnetron sputtering is used for preparing thin NbN films. The films are deposited on sapphire substrates at temperatures from 20 to 300°C. The superconducting transition temperature for various samples is in the range of 8–14 K depending on the substrate temperature during deposition. The critical current density jc is in the range of 0.8–8 MA/cm2, which makes it possible to use these films to create multilayer structures due to the absence of anneals, which each underlying layer of structures is subjected to during the deposition of each subsequent layer.
Relaxin, a pleiotropic vasodilator for the treatment of heart failure (2008)

Relaxin is a naturally occurring peptide hormone that plays a central role in the hemodynamic and renovascular adaptive changes that occur during pregnancy. Triggering similar changes could potentially be beneficial in the treatment of patients with heart failure. The effects of relaxin include the production of nitric oxide, inhibition of endothelin, inhibition of angiotensin II, production of VEGF, and production of matrix metalloproteinases. These effects lead to systemic and renal vasodilation, increased arterial compliance, and other vascular changes. The recognition of this has led to the study of relaxin for the treatment of heart failure. An initial pilot study has shown favorable hemodynamic effects in patients with heart failure, including reduction in ventricular filling pressures and increased cardiac output. The ongoing RELAX-AHF clinical program is designed to evaluate the effects of relaxin on the symptoms and outcomes in a large group of patients admitted to hospital for acute heart failure. This review will summarize both the biology of relaxin and the data supporting its potential efficacy in human heart failure.
Rapid Communication: MicroRNA co-expression network reveals apoptosis in the reproductive tract during molting in laying hens1,2 (2017)

The aim of this study was to determine the regulatory mechanisms of molting and recrudescence via studying the micro-RNA (miRNA) expression in the oviduct of laying hens. We performed a cDNA microarray analysis in the magnum tissue from the oviduct to identify the whole miRNA profiles through the molting and recrudescence periods. A total of 35 laying hens (47-wk-old) were divided into 7 groups (0 d: a control group; 6 and 12 d: 2 molting-period groups fed on a high-zinc diet; and 20, 25, 30, and 35 d: 4 recrudescence-period groups fed on a normal diet after a 12-d period on a high-zinc diet). An miRNA co-expression network (miRCN) was generated using the differentially expressed miRNA (DEM) according to the entire data integration. The significantly co-expressed miRNA ( = 111) were highly differentially expressed from 12 to 20 d, which was a transition period between molting and recrudescence, while their expression patterns were contrary to the estrogen changes. The targets of highly connected miRNA ( = 12) indicated the significant biological pathways and gene ontology (GO) terms, such as MAPK and Wnt signaling and magnesium-ion binding, which are associated with apoptotic activities. These results suggest that the miRNA of the miRCN might play a role in the apoptotic progression of the reproductive tract during molting.
ChemInform Abstract: New Carbohydrate‐Based Chiral Auxiliaries in Diels—Alder Reaction. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Use of diffracted light from latent images to improve lithography control (1992)

As the microelectronics industry strives to achieve smaller device design geometries, control of linewidth, or critical dimension (CD), becomes increasingly important. Currently, CD uniformity is controlled by exposing large numbers of samples for a fixed exposure time which is determined in advance by calibration techniques. This type of control does not accommodate variations in optical properties of the wafers that may occur during manufacturing. In this work, a relationship is demonstrated between the intensity of light diffracted from a latent image consisting of a periodic pattern in the undeveloped photoresist and the amount of energy absorbed by the resist material (the exposure dose). This relationship is used to simulate exposure control of photoresist on surfaces having slight variations in optical properties, representative of those found in operating process lines. We demonstrate that linewidth uniformity of the developed photoresist can be greatly improved when the intensity of diffracted light from the latent image is used to control the exposure dose. Samples include a variety of photoresist materials and substrates with a wide range of optical properties. To verify the experimental observations, diffractions from the latent image grating structures is modeled using rigorous coupled wave analysis. The modeling is used to predict the diffraction from a latent image as a function of the substrate optical properties and the parameters of the latent image (i.e., linewidth, sidewall angle). Good agreement is obtained between theoretical and experimental observations. Conversely, the inverse problem is solved in which the parameters of the diffracting structure (the latent image) are determined from a measurement of the diffracted power. Therefore, the diffracted power can be monitored for the purpose of determining when the latent image will produce the proper CD upon development.
Browser And Applet Interfaces To Cebus Networks (1997)

The design and implementation of a Web-browser based interface to CEBus networks is described. The interface supports browsing and navigation of a CEBus network and the user can interact with CEBus devices on the network, and access and control CAL context and object structures within these devices. The interface can be used to access a local CEBus network from a standard desktop PC, or from a Web-TV or set-top box system with built-in CEBus interface hardware. Furthermore, as the interface is implemented using conventional Web-browser technology it can also serve as a full Internet interface to a home network which provides an Internet/CEBus gateway. Such a system can provide access and control services to the home network from any computer with an Internet connection.
Performance evaluation of compounding and directional beamforming techniques for carotid strain imaging using plane wave transmissions (2014)

Carotid strain imaging in 3D is not possible with conventional focused imaging, because the frame rate is too low. Plane wave ultrasound provides sufficiently high frame rates, albeit at the cost of image quality, especially in the off-axis direction due to the lack of focusing. Multiple techniques have been developed to cope with the low off-axis image quality when performing 2D (and in future 3D) motion estimation: cross correlation with directional beamforming (with or without RF (coherent) compounding) and displacement compounding. This study compares the precision of these techniques using linear array ultrasound data of a pulsating concentric homogeneous artery simulated using Field II. The transducer (f <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</inf> = 9 MHz, pitch = 197.9 µm, 192 elements, f <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">s</inf> = 180 MHz) transmitted plane waves at 3 sequentially alternating angles (0°, +θ, −θ) at a PRF of 2 kHz. Simulations were repeated for θ ranging from 1° to 20° with increments of 1°. Displacements were estimated for frame intervals of 1/15th s, tracked, and cumulated from diastole to systole using either displacement compounding, or directional beamforming optionally enhanced by RF compounding. 1D directional beamforming with RF compounding and 2D displacement compounding with θ = ∼20° performed equally and best with a relative root-mean-squared error of ∼2% with respect to the analytical solution. The mean and standard deviation of the estimated motion direction for 2D displacement compounding with θ = 20° was 0.03° +/− 1.43°. Since displacement compounding requires no assumptions regarding the motion direction, this technique seems the best option for plane wave carotid strain imaging.
Simultaneous measurement of times-of-flight and communications in acoustic sensor networks (2006)

This article presents a process for the simultaneous determination of distances among objects in an indoor localization system using an acoustic sensor network. The proposed technique is based on a simultaneous time-of-flight measurement for the emitted acoustic signals from every object, without needing any additional signal to be used for synchronization. This is possible thanks to the properties of the used emission codification, which consists of complementary sets of sequences. According to the requirements of the positioning algorithm, a communication protocol is designed in order to transmit the collected information among nodes, so, locally, the distances and positions can be computed at each node.
Reactions of fluorocarbon radicals. Part XIII. Alternative syntheses, properties, and spectra of trifluoro-nitroso- and -nitro-methane (1954)

J. Jander and R. N. Haszeldine, J. Chem. Soc., 1954, 912 DOI: 10.1039/JR9540000912
High Temperature Stability of Bulk Ti<sub>3</sub>SiC<sub>2</sub> Materials in Air (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Implementación de un sistema interactivo de respuestas de los alumnos a preguntas enunciadas en las clases, con correción inmediata (2012)

Memoria ID11-141. Ayudas de la Universidad de Salamanca para la innovacion docente, curso 2011-2012.
Impact of age on sorafenib outcomes in hepatocellular carcinoma: an international cohort study (2020)

Clinical outcomes in the elderly is equivalent to patients aged <75 years, independent of dose of sorafenib prescribed.
Neuroprotection by pigment epithelial‐derived factor against glutamate toxicity in developing primary hippocampal neurons (1999)

Pigment epithelial-derived factor (PEDF) has been shown to be a survival factor for cerebellar granule neurons. Here we investigated the ability of PEDF to enhance the survival of hippocampal neurons in culture, and to protect these neurons against acute glutamate toxicity. Hippocampal neurons prepared from 1- to 3-day postnatal rat brain were cultured for either 7 or 14 days in vitro (DIV). At 14 DIV, neurons were only slightly protected (13% ± 4%) against 50 μM glutamate toxicity when treated with 1 μg/ml of PEDF for 3 successive days before glutamate exposure as measured by lactate dehydrogenase (LDH) release. In comparison, basic fibroblast growth factor (bFGF) at 10 ng/ml for the same treatment period protected 58% ± 8% of the neurons against glutamate. Using quantitative image analysis of digitized micrographs, we found that the average size of neurons in young, developing hippocampal cultures (7 DIV), was greatly decreased by treatment with 50 μM glutamate. Treatment for up to 5 successive days with 1 μg/ml of PEDF before glutamate addition dramatically increased the average hippocampal neuron soma size, compared to cells treated with glutamate alone. Thus, PEDF may promote the growth of hippocampal neurons, and, if added to developing hippocampal neurons, can also protect these cells from subsequent injury, such as the excitotoxicity of glutamate. J. Neurosci. Res. 56:604–610, 1999. © 1999 Wiley-Liss, Inc.
Glassy free-form 3D micro-optics enabled via ultrafast laser 3D nanolithography (2021)

Here we report on the laser manufacturing of glass true 3D micro-optics. We demonstrate the feasibility of producing individual free-form geometry elements such as lenses, prisms, gratings proving the potential of integration into monolith stacked components. This is achieved by combining ultrafast laser 3D nanolithography and subsequent thermal post-treatment (calcination) - a novel approach introduced for additive manufacturing of inorganic materials [Nanoscale Horiz. 4, 647 (2019)]). The laser made pristine micro-optical components maintain their predefined shape while material is converted from hybrid polymer to glass corresponding to its inherent refractive index and transparency. This approach enables both realization of complex geometries and variation of material properties simultaneously.
Disproportionation of digermane in liquid ammonia (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDisproportionation of digermane in liquid ammoniaRobert M. Dreyfuss and William L. JollyCite this: Inorg. Chem. 1968, 7, 12, 2645–2646Publication Date (Print):December 1, 1968Publication History Published online1 May 2002Published inissue 1 December 1968https://pubs.acs.org/doi/10.1021/ic50070a037https://doi.org/10.1021/ic50070a037research-articleACS PublicationsRequest reuse permissionsArticle Views33Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts