gebhart/patrepeval huggingface dataset:
Autonomic markers of arousal during sleep in patients undergoing investigation for obstructive sleep apnoea, their relationship to EEG arousals, respiratory events and subjective sleepiness (1998)

Estimating the degree of sleep fragmentation is an important part of a respiratory sleep study and is conventionally measured using EEG micro arousals or is inferred indirectly from respiratory abnormalities such as apnoeas and desaturations. There is a need for less labour-intensive measures of sleep fragmentation, and transient rises in blood pressure and heart rate may fulfil this role. Forty unselected sleep clinic referrals undergoing investigation for possible obstructive sleep apnoea (OSA) were studied with one night of polysomnography. Three conventional indices of sleep fragmentation (EEG micro arousals, apnoea/hypopnoea index (AHI) and oxygen saturation dip rate (SaO2 dips)) and two autonomic indices (heart rate and blood pressure rises) have been compared. Correlations between these five indices ranged from r=0.38 to r=0.73. Of the two autonomic indices, the correlations for blood pressure rises with SaO2 dips and EEG micro arousals were stronger (r=0.71 and r=0.65, respectively) than those for heart rate rises (0.55 and 0.51). All indices of sleep fragmentation, apart from heart rate rises, were similar in their correlation with subjective sleepiness (r-values 0.21-0.36). Arousals implied from blood pressure rises (using pulse transit time) can be measured easily, are objective, and appear no worse at predicting subjective sleepiness than either EEG micro arousals or AHI. They may therefore provide a useful alternative to manual scoring of micro arousals from the EEG as an index of sleep fragmentation in sleep clinic patients undergoing investigation for possible OSA.
Ferroelectric Polymer Gate Transistor as a Model System for Exploring the Mechanisms of the Retention Loss (2010)

An attractive combination of properties of the ferroelectric copolymer of vinylidene fluoride and trifluoroethylene (P(VDF-TrFE)), including a relatively high spontaneous polarization and low dielectric constant as well as low processing temperature makes this material useful for studying the ferroelectric gate operation for 1T nonvolatile ferroelecetric memory applications. Here we explore a silicon-based ferroelectric field effect transistor with P(VDF-TrFE) gate showing a persistent switching of the drain current with the "on"/"off" current ratio of 10(3)-10(2) and retention exceeding 5 days. The physical mechanism of the retention loss has been addressed by monitoring the drain current relaxation in combination with the time-resolved piezo-force scanning probe microscopy. The results suggest that the retention loss is controlled by the polarization screening due to the charge injection into the interface-adjacent layer rather than the polarization loss due to the depolarization effect.
Increasing the Measuring Accuracy of a Sensory Swing Clamp by Multi-Sensor Evaluation (2019)

Abstract The growing flexibility of modern production systems complicates the quality assurance and process safety of mechanical processing. As an import component of milling machines, the workpiece clamping systems plays a quality-determining role within every milling process. Thus, a sensory workpiece clamping system that utilizes sensory swing clamps was developed in former research work in order to provide monitoring capabilities. This contribution deals with the experimental analysis of the multiple integrated sensors of the sensory swing clamp and the characterization of their measuring capability toward different measurands. By means of the stepwise linear regression method, different models were developed that enable the determination of the clamping force, the hydraulic pressure, and the piston position. The results verify that the multi-sensor evaluation significantly increases the measuring accuracy of a sensory swing clamp. Thus, the measuring accuracy is measurable with a standard deviation of 0.05 MPa for the hydraulic pressure, 101 N for the clamping force, and 0.62 mm for the piston position. Furthermore, the practicability and flexible use at varying boundary conditions is proved.
Fuel cells: applied research fuel cell materials and electrocatalysis. Annual report, January 1-December 31, 1977 (1978)

Separate abstracts were prepared for the four sections included. (WHK)
Paradigm Shift in the Management of Irresectable Colorectal Liver Metastases (2018)

LT poses a valid treatment option for i-CRLM. In times of organ paucity, "living donor-RAPID" procedure may represent a paradigm shift in the management of i-CRLM.
Dosimetry in a Myeloablative Setting (2002)

In clinical therapy trials using high dosages of systemically administered radioactivity to treat cancer, myeloablation may occur. This is either an effect of the circulating radioactivity labeled to antibodies exposing the bone marrow to radiation, or it may occur because malignant cells in the bone marrow are targeted. Bone marrow cells may be targeted through antigens expressed on cells in the bone marrow or because radioactivity is targeted to the skeleton. Assessment of radiation absorbed dose to the marrow may be useful for dose escalation or individualized patient treatment planning. With successful preservation of marrow function with autologous marrow or peripheral blood stem cell transplantation, other normal organs may also receive sufficient radiation to show toxicity. Accurate dose estimates to these organs is important for the design of future studies in order to minimize or avoid toxicity. This paper reviews internally administered high dose radiation therapy studies, and examines the radiation absorbed dose estimates reported from these studies.
Visit-to-Visit and Ambulatory Blood Pressure Variability as Predictors of Incident Cardiovascular Events in Patients With Hypertension (2012)

These findings suggest that visit-to-visit BPV and ambulatory BPV are separately useful in predicting cardiovascular outcomes.
Monoclonal anti‐VH antibodies recognize a common VH determinant expressed on immunoglobulin heavy chains from various species (1983)

Our previous work using rabbit antibodies to the variable region of MOPC315 myeloma heavy chain (VH) has indicated the existence of framework determinant(s) common to many murine heavy chains. Here we report the characterization of anti-VH monoclonal antibodies (mAb) prepared in an attempt to elucidate the nature of the common VH determinant. We immunized AKR/J mice with a purified VH315 fragment and generated somatic cell hybrids by the fusion of the immune AKR/J splenocytes with the NS1 myeloma cells. Thirty-seven common anti-VH and 57 subgroup VHI-specific hybridomas have been established and characterized. Whereas the anti-subgroup mAb seemed to react with a determinant unique to the MOPC315 (mouse VHI) subgroup, all the anti-VH mAb reacted with myeloma heavy chains of different VH subgroups, class and allotypes. Antibody competition studies revealed that the VH subgroup determinants are distinct from the common VH determinants and that both were also recognized by the rabbit polyclonal antibodies. The common VH determinants were found to be "hidden" determinants on intact immunoglobulin molecules being exposed only on isolated heavy chains. Furthermore, they are sequential determinants since they are preserved on fully denatured heavy chains. The common VH determinants are shared by immunoglobulins of a wide range of vertebrates from amphibia to man and thus represent antigenic structures which were highly conserved throughout evolution.
Direct Amination of Aromatic Boronic Acids with Aqueous Ammonia (2009)

The direct copper-catalyzed amination of (hetero)arylboronic acids with aqueous ammonia constitutes a new economical and highly expedient method for the introduction of an NH2 group. This reaction displays a remarkable functional group tolerance, that does not only allow the conversion of arylboronic acids bearing highly sensitive groups such as nitro and aldehyde groups, but also highly acidic functionalities. The reaction proceeds under air at room temperature which makes it an exceedingly convenient procedure for practical handling.
Development of an EUVL collector with infrared radiation suppression (2014)

Laser-produced plasma (LPP) sources for extreme ultraviolet lithography (EUVL) systems utilize CO<sub>2</sub> lasers operating with wavelength 10.6&mu;m. Since multilayer-coated optics have high reflectivity for this infrared radiation (IR), a significant and detrimental amount of IR is passed through the EUVL system. One method to remove the IR from the system is to utilize a binary diffraction grating. When this grating is applied directly to the surface of the primary collector optic of the source, the majority of the IR is diverted outside the radius of the exit aperture at the intermediate focus (IF). This paper will report details on the performance of a full size (410mm diameter) Demonstration Collector utilizing IR rejection (IRR) technology with the capability to produce over 125X suppression of IR, equaling the performance of a IR spectral filter. Additional details will be reported on the technology development and use of a glassy smoothing layer to enable high EUV performance, a weighted average multilayer reflectance of 50.9% for unpolarized EUV radiation.
Regulation of vascular endothelial growth factor expression in human colon cancer by insulin-like growth factor-I. (1998)

We investigated the role of insulin-like growth factor (IGF)-I and IGF-binding proteins (IGFBPs) in the regulation of vascular endothelial growth factor (VEGF) expression in colon cancer cells and the mechanism by which this regulation occurs. HT29 human colon cancer cells were treated with IGF-I for various time periods. VEGF mRNA expression increased within 2 h and peaked at 24 h. SW620 colon cancer cells exhibited a peak induction of VEGF mRNA 8 h after IGF-I treatment. IGF-I induction of VEGF was confirmed at the protein level. In experiments using transient transfection of VEGF promoter-reporter constructs into HT29 cells, IGF-I increased the activity of the VEGF promoter, and pretreatment of HT29 cells with dactinomycin abrogated the induction of VEGF mRNA by IGF-I. The half-life of VEGF mRNA was not prolonged by treatment with IGF-I. Blocking the activity of IGFBP-4 did not significantly modulate the effect of IGF-I induction of VEGF mRNA in HT29 cells. Treating cells with des-(1-3)-IGF-I (an active derivative of IGF-I that does not bind to binding proteins) had effects on VEGF mRNA expression that were similar to those of IGF-I. These findings suggest that IGF-I regulates VEGF expression in human colon cancer cells by induction of transcription of the VEGF gene. IGFBPs do not significantly affect IGF-I induction of VEGF.
A Whole Body Attitude Stabilizer for Hybrid Wheeled-Legged Quadruped Robots (2018)

This work presents a new attitude balancing strategy implemented and validated on a quadrupedal robot equipped with a custom hybrid wheel-legged mobility system. The proposed method uses an inverse kinematics solution scheme based on Quadratic Programming optimization to generate full body motions that ensure the desired balancing performances. The strategy generates a compliant behaviour to cope with the applied external forces resulting in a stable and smooth reaction response. Furthermore, the method takes advantage of the robot hybrid wheeled-legged mobility system to provide new motion capabilities and balancing reactions as it will be shown through the paper. Extensive simulation studies on the Centauro robot are presented. Results show the efficiency of the propose method demonstrating significant contribution in the rejection of the applied external disturbances.
Advances in the use of biologic agents for the treatment of systemic vasculitis (2008)

Biologic agents represent the next evolution in treatment for the primary systemic vasculitides. Greater understanding of these diseases has allowed us to move further away from nonspecific, highly toxic therapies toward a more directed approach. As our experience with these agents increases, they will likely form the keystone of treatment in the near future.
Pulse switching and stability in FM mode-locked fiber lasers (2005)

We investigate the dynamics of the pulse switching mechanism in FM mode-locked fiber lasers for what we believe to be the first time. Two completely different pulse switching mechanisms are identified.
Global localization of 3D anatomical structures by pre-filtered Hough Forests and discrete optimization (2013)

The accurate localization of anatomical landmarks is a challenging task, often solved by domain specific approaches. We propose a method for the automatic localization of landmarks in complex, repetitive anatomical structures. The key idea is to combine three steps: (1) a classifier for pre-filtering anatomical landmark positions that (2) are refined through a Hough regression model, together with (3) a parts-based model of the global landmark topology to select the final landmark positions. During training landmarks are annotated in a set of example volumes. A classifier learns local landmark appearance, and Hough regressors are trained to aggregate neighborhood information to a precise landmark coordinate position. A non-parametric geometric model encodes the spatial relationships between the landmarks and derives a topology which connects mutually predictive landmarks. During the global search we classify all voxels in the query volume, and perform regression-based agglomeration of landmark probabilities to highly accurate and specific candidate points at potential landmark locations. We encode the candidates' weights together with the conformity of the connecting edges to the learnt geometric model in a Markov Random Field (MRF). By solving the corresponding discrete optimization problem, the most probable location for each model landmark is found in the query volume. We show that this approach is able to consistently localize the model landmarks despite the complex and repetitive character of the anatomical structures on three challenging data sets (hand radiographs, hand CTs, and whole body CTs), with a median localization error of 0.80 mm, 1.19 mm and 2.71 mm, respectively.
Recruitment of lymphocytes to the human liver (2002)

This review discusses the function and localisation of lymphocytes resident within the human liver, under both physiological and pathological conditions. Through description of the mechanisms that mediate lymphocyte recruitment into tissues, this article explains how hepatic endothelial and epithelial cells regulate the recruitment of specific lymphocyte subpopulations. We illustrate that the expression of adhesion molecules and chemokines is crucial to the control of lymphocyte adhesion. Thus, in the normal liver, adhesion molecules such as vascular adhesion protein-1 (VAP-1), intercellular adhesion molecule-1 (ICAM-1) and intercellular adhesion molecule-2 (ICAM-2), and chemokines such as regulated on activation, normal T cell expressed and secreted (RANTES), monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-1alpha (MIP-1alpha), interferon gamma inducible protein-10 (IP-10), MIG and interferon inducible T-cell alpha chemoattractant (ITAC) are involved in lymphocyte binding to different endothelial compartments. However, in response to inflammation or injury, additional expression of adhesion molecules such as VCAM-1, p-selectin and e-selectin, as well as higher levels of chemokines, permits the attraction and retention of specific effector populations of lymphocytes. We also discuss the expression and function of a newly defined adhesion protein, (VAP-1), and suggest that the unique functions of this protein may provide therapeutic potential for the treatment of liver disease.
Travaux de recherche en France dans le domaine des horloges compactes à jet de césium pompé optiquement (2003)

National audience
A Handy Dandy Doherty PA: A Linear Doherty Power Amplifier for Mobile Handset Application (2017)

As wireless communications progress from second to fourth-generation (4G) systems, the information content drastically increases, requiring high-data-rate transmissions. For efficient use of precious spectrum resources, the modulated signals have wider bandwidths (BWs) and higher peak-toaverage power ratios (PAPRs) than previous generations of systems. Therefore, the power amplifier (PA) operates at a less efficient backoff-power region to achieve the required linearity.
Multiverse (2013)

Algorithmic speculation or high-level speculation is a promising programming paradigm which allows programmers to speculatively branch an execution into multiple independent parallel sections and then choose the best (perhaps fastest) amongst them. The continuing execution after the speculatively branched section sees only the modifications made by the best one. This programming paradigm allows programmers to harness parallelism and can provide dramatic performance improvements.
SSDAN: Multi-Source Semi-Supervised Domain Adaptation Network for Remote Sensing Scene Classification (2021)

We present a new method for multi-source semi-supervised domain adaptation in remote sensing scene classification. The method consists of a pre-trained convolutional neural network (CNN) model, namely EfficientNet-B3, for the extraction of highly discriminative features, followed by a classification module that learns feature prototypes for each class. Then, the classification module computes a cosine distance between feature vectors of target data samples and the feature prototypes. Finally, the proposed method ends with a Softmax activation function that converts the distances into class probabilities. The feature prototypes are also divided by a temperature parameter to normalize and control the classification module. The whole model is trained on both the unlabeled and labeled target samples. It is trained to predict the correct classes utilizing the standard cross-entropy loss computed over the labeled source and target samples. At the same time, the model is trained to learn domain invariant features using another loss function based on entropy computed over the unlabeled target samples. Unlike the standard cross-entropy loss, the new entropy loss function is computed on the model’s predicted probabilities and does not need the true labels. This entropy loss, called minimax loss, needs to be maximized with respect to the classification module to learn features that are domain-invariant (hence removing the data shift), and at the same time, it should be minimized with respect to the CNN feature extractor to learn discriminative features that are clustered around the class prototypes (in other words reducing intra-class variance). To accomplish these maximization and minimization processes at the same time, we use an adversarial training approach, where we alternate between the two processes. The model combines the standard cross-entropy loss and the new minimax entropy loss and optimizes them jointly. The proposed method is tested on four RS scene datasets, namely UC Merced, AID, RESISC45, and PatternNet, using two-source and three-source domain adaptation scenarios. The experimental results demonstrate the strong capability of the proposed method to achieve impressive performance despite using only a few (six in our case) labeled target samples per class. Its performance is already better than several state-of-the-art methods, including RevGrad, ADDA, Siamese-GAN, and MSCN.
Pulse Combustion: Demonstration of the Characteristic Mixing Time in a Commercial Burner (1989)

Abstract The response of a prototype Helmholtz-type commercial pulse combustor to changes in two fundamental characteristic times has been investigated both experimentally and numerically. The natural resonant frequency and the fluid dynamic mixing geometry were modified separately. The response of the combustor to these changes was determined by measurements of pressure, frequency, and OH· chemiluminescence. The combustion chamber volume was modified to change the resonant frequency of the combustor. Changes in the fluid dynamic mixing time were obtained by injecting premixed reactants axially and then temporally and spatially modifying the injection profile by varying the geometry of a novel injection system. A wide dynamic range in pressure amplitude and frequency was obtainable by changing the characteristic fluid dynamic mixing time. Results from systematic changes in these two parameters compare well with the results from the numerical model of a pulse combustor that has been developed at Sandia National Laboratories.
Novel Acylated Flavonol Tetraglycoside with Inhibitory Effect on Lipid Accumulation in 3T3-L1 Cells from Lu’an GuaPian Tea and Quantification of Flavonoid Glycosides in Six Major Processing Types of Tea (2017)

A novel acylated flavonol tetraglycoside, kaempferol 3-O-[(E)-p-coumaroyl-(1→2)][α-l-arabinopyranosyl-(1→3)][β-d-glucopyranosyl (1→3)-α-l-rhamnopyranosyl(1→6)]-β-d-glucopyranoside (camellikaempferoside C, 1), together with 2 flavonols and 18 flavone and flavonol glycosides (FGs) (2-21) was isolated from the green tea Lu'an GuaPian (Camellia sinensis L.O. Kuntze). Their structures were identified by spectroscopic and chemical methods. Four acylated FGs (1, 7, 8, 9) were found to inhibit the proliferation and differentiation of 3T3-L1 preadipocytes at concentrations of 25, 50, and 100 μM (P < 0.05). Furthermore, we established a rapid UPLC method to quantify nine FGs in six major processing types of tea. The results showed that dark tea had the highest amount of 20 (0.70 ± 0.017 mg/g) and black tea had the highest amount of 8 (0.09 ± 0.012 mg/g), whereas the amounts of 10 and 16 basically decreased with the increasing degree of fermentation and could contribute to the discrimination of different processing types of tea.
Theoretical Prediction of the Hydrogen-Bond Basicity pKHB (2002)

Ab initio and DFT calculations on around 65 hydrogen bond or Lewis bases and their complexes with hydrogen fluoride have been performed, and a range of calculated properties from both free bases and complexes correlated with pKHB, an experimental scale of hydrogen-bond basicity. For the entire range of bases, we found that the hydrogen-bond binding Gibbs free energy computed at the B3LYP/6-31+G(d,p) level of theory linearly correlated with pKHB. Further improvements in the correlation and prediction of pKHB were possible with a non-linear fit by considering the hydrogen bonding Gibbs free energy of another possible stereoisomeric 1:1 complex and/or that of a linear 2:1 complex, which included a second hydrogen fluoride.