gebhart/patrepeval huggingface dataset:
Cysteine-rich protein 2 is a downstream effector of cGMP-dependent protein kinase I in nociception : poster presentation (2007)

The experience of pain is mediated by a specialized sensory system, the nociceptive system. There is considerable evidence that the cGMP/cGMP kinase I (cGKI) signaling pathway modulates the nociceptive processing within the spinal cord. However, downstream targets of cGKI in this context have not been identified to date. In this study we investigated whether cysteine-rich protein 2 (CRP2) is a downstream effector of cGKI in the spinal cord and is involved in nociceptive processing. Immunohistochemistry of the mouse spinal cord revealed that CRP2 is expressed in superficial laminae of the dorsal horn. CRP2 is colocalized with cGKI and with markers of primary afferent C fibers. Importantly, the majority of CRP2 mRNA-positive dorsal root ganglion (DRG) neurons express cGKI and CRP2 is phosphorylated in a cGMP-dependent manner. To elucidate the functional role of CRP2 in nociception, we investigated the nociceptive behavior of CRP2-deficient (CRP2-/-) mice. Touch perception and acute thermal nociception were unaltered in CRP2-/- mice. However, CRP2-/- mice showed an increased nociceptive behavior in models of persistent pain as compared to wild type mice. Intrathecal administration of cGKI activating cGMP analogs increased the nociceptive behavior in wild type but not in CRP2-/- mice, indicating that the presence of CRP2 was essential for cGMP/cGKI-mediated nociception. These data indicate that CRP2 is a new downstream effector of cGKI-mediated spinal nociceptive processing and point to an inhibitory role of CRP2 in the generation of inflammatory pain.
Metal Hydride Compression (2016)

Conventional hydrogen compressors often contribute over half of the cost of hydrogen stations, have poor reliability, and have insufficient flow rates for a mature fuel cell vehicle market. Fatigue associated with their moving parts including cracking of diaphragms and failure of seals leads to failure in conventional compressors, which is exacerbated by the repeated starts and stops expected at fueling stations.
The pyrenoidal linker protein EPYC1 phase separates with hybrid Arabidopsis–Chlamydomonas Rubisco through interactions with the algal Rubisco small subunit (2019)

Photosynthetic efficiencies in plants are restricted by the CO2-fixing enzyme Rubisco but could be enhanced by introducing a CO2-concentrating mechanism (CCM) from green algae, such as Chlamydomonas reinhardtii (hereafter Chlamydomonas). A key feature of the algal CCM is aggregation of Rubisco in the pyrenoid, a liquid-like organelle in the chloroplast. Here we have used a yeast two-hybrid system and higher plants to investigate the protein-protein interaction between Rubisco and essential pyrenoid component 1 (EPYC1), a linker protein required for Rubisco aggregation. We showed that EPYC1 interacts with the small subunit of Rubisco (SSU) from Chlamydomonas and that EPYC1 has at least five SSU interaction sites. Interaction is crucially dependent on the two surface-exposed α-helices of the Chlamydomonas SSU. EPYC1 could be localized to the chloroplast in higher plants and was not detrimental to growth when expressed stably in Arabidopsis with or without a Chlamydomonas SSU. Although EPYC1 interacted with Rubisco in planta, EPYC1 was a target for proteolytic degradation. Plants expressing EPYC1 did not show obvious evidence of Rubisco aggregation. Nevertheless, hybrid Arabidopsis Rubisco containing the Chlamydomonas SSU could phase separate into liquid droplets with purified EPYC1 in vitro, providing the first evidence of pyrenoid-like aggregation for Rubisco derived from a higher plant.
Global for Coarse and Part for Fine: A Hierarchical Action Recognition Framework (2018)

Action recognition is one significant yet challenging task in computer vision. Recent methods mainly model an end-to-end one-stage non-deep or deep learning networks to distinguish different action categories. In this paper we introduce one novel hierarchical action classification framework: Unlike existing one-stage recognition models, the proposed work improves the recognition accuracy by: 1) developing a hierarchical coarse-to-fine action classification framework by dividing the recognition processing into two stages: coarse- grained classification and fine-grained classification, and 2) representing actions in different stages with different granularity features representation: global features are utilized for coarse classifiers while more body parts patterns for fine-grained classifiers are aggregated. Experiments on two widely-tested benchmark datasets show that our method can achieve state-of-the-art or competitive performance compared with existing results using one-stage models, with advantages regarding the recognition accuracy and robustness.
Reduced locus coeruleus integrity linked to response inhibition deficits in parkinsonian disorders (2021)

Abstract Parkinson’s disease and progressive supranuclear palsy (PSP) both impair response inhibition, exacerbating impulsivity. Inhibitory control deficits vary across individuals, and have been linked with worse prognosis and lack of improvement on dopaminergic therapy. Motor and cognitive control are associated with noradrenergic innervation of the cortex, arising from the locus coeruleus noradrenergic system. Here we test the hypothesis that loss of structural integrity of the locus coeruleus explains response inhibition deficits in progressive supranuclear palsy and Parkinson’s disease. This cross-sectional observational study recruited 24 people with idiopathic Parkinson’s disease, 14 with PSP-Richardson’s syndrome, and 24 age- and sex-matched controls. All participants undertook a stop-signal task and ultrahigh field 7T-magnetic transfer weighted imaging of the locus coeruleus. Hierarchical Bayesian estimation of the parameters of ‘race models’ of go-versus stop-decisions was used to quantify the cognitive processes of response inhibition. We tested the multivariate relationship between locus coeruleus integrity and model parameters using partial least squares. Both disorders impaired response inhibition at the group level. Progressive supranuclear palsy caused a distinct pattern of abnormalities in inhibitory control, relative to Parkinson’s disease and healthy controls, with a paradoxically reduced threshold for go responses, but longer non-decision times, and more lapses of attention. The variation in response inhibition correlated with variation in the integrity of the locus coeruleus, across participants in both clinical groups. Structural imaging of the locus coeruleus, coupled with behavioural modelling in parkinsonian disorders, confirms that locus coeruleus integrity is associated with response inhibition and its degeneration contributes to neurobehavioural changes. The noradrenergic system is therefore a promising target to treat impulsivity in these conditions. The optimisation of noradrenergic treatment is likely to benefit from stratification according to locus coeruleus integrity.
FRESH WHOLE BLOOD IS THE BEST 24-h HYPOTENSIVE RESUSCITATIVE FLUID IN SEVERE HEMORRHAGE IN SWINE (2006)

Objective: To determine which fluids best sustain long-term survival during hypotensive resuscitation (SBP 80 ± 2 mmHg) following hemorrhage (HEM). Methods: We compared LR, Hextend (HEX), hemoglobin-based oxygen carrier (HBOC, Polyheme), 5% NaCl (HS), 7.5% NaCl in 6% Dextran-70 (HSD), and fresh whole blood (FWB) during 24 h of hypotensive resuscitation following HEM in 40-kg swine. Ten min after HEM (37 ml/kg), hypotensive resuscitation for 24 h was begun. HS (9 ml/kg) and HSD (6 ml/kg) were followed by LR. Two control groups included: 1) full resuscitation (FullR) = LR and shed blood; and 2) no-resuscitation (NoR). At 24 h, blood and LR were given and pigs were monitored 72 h. Results: For NoR, 50% died in 1 h; for HBOC: 5 h; for HS, HSD, LR, and HEX: 5.5 h. For FWB, one death at 13 h; 7 animals survived 72 h. LR, HEX, HS, HSD, and HBOC prolonged survival compared to NoR, while FWB extended the hypotensive survival time similar to full resuscitation (Left Figure). FWB was the only fluid which was able to maintain O2 delivery high enough to meet demand, or at a ratio > 1 (Right Figure).FigureConclusion: Asanguinous fluids (LR, HEX, HS, HSD), and HBOC should only be used for hypotensive resuscitation 4 to 6 h. FWB is the best fluid for hypotensive resuscitation for hemorrhagic shock and works by maintaining an adequate O2 delivery to demand. Supported by US Army Med. Res. & Materiel Cmd. * p < 0.05 different from groups connected by lines.
A hybrid bipy–NHC ligand for the construction of group 11 mixed-metal bimetallic complexes (2021)

An asymmetric bipy/NHC ligand L has been used to construct Au/Au, Au/Ag and Au/Cu bimetallic complexes through prior coordination of the NHC to Au(i) and subsequent introduction of the second group 11 metal ion at the bipy donor of the hybrid ligand. The complex [Au(κ<sup>C</sup>-L)<sub>2</sub>]BF<sub>4,</sub>1, has been used as the precursor for the formation of [AuAg(κ-<i>C</i> <sup>Au</sup>,κ<sup>2</sup>-<i>N</i>,<i>N</i>'<sup>Ag</sup>-1)<sub>2</sub>](BF<sub>4</sub>)<sub>2</sub>, 2a, [AuCu(κ-<i>C</i> <sup>Au</sup>,κ<sup>2</sup>-<i>N</i>,<i>N</i>'<sup>Cu</sup>-1)<sub>2</sub>](BF<sub>4</sub>)<sub>2</sub>, 2b and [AuAu'(κ-C<sup>Au/Au'</sup>,κ<sup>1</sup>-N<sup>Au/Au'</sup>-1)<sub>2</sub>](BF<sub>4</sub>)<sub>2</sub>, 3.
Preparation and properties of dimethyl phosphonomethyl methylsiloxane dimethylsiloxane copolymers (1987)

Abstract Dimethyl phosphonomethylheptamethylcyclotetrasiloxane (II) and 1, 3‐bis(dimethyl phosphonomethyl)tetramethyldisiloxane (III) have been prepared by Arbuzov reaction of trimethyl phosphite with bromomethylheptamethylcyclotetrasiloxane (I) and 1, 3‐bis(bromomethyl)tetramethyldisiloxane, respectively. Dimethyl phosphonomethylmethylsiloxane dimethylsiloxane copolymers have been prepared by acid‐catalyzed ring‐opening polymerization of II with hexamethyldisiloxane (MM) as an end‐capping reagent and by reaction of II with III as an end‐capping reagent. Dimethylsiloxane polymers with dimethyl phosphonomethyldimethylsiloxy end groups have been prepared by acid‐catalyzed polymerization of octamethylcyclotetrasiloxane (D 4 ) and III. Under these conditions hydrolysis of the dimethyl phosphonate ester groups was a problem. On the other hand Arbuzov reaction of trimethyl phosphite with bromomethylmethylsiloxane dimethylsiloxane copolymer gave a dimethyl phosphonomethylmethylsiloxane dimethylsiloxane copolymer with uniform properties. These polymers have been characterized by 1 H‐, 13 C‐, 29 Si‐, and 31 P‐NMR spectroscopy. Their molecular weight distributions have been determined by gel permeation chromatography (GPC) and their thermal stability measured by TGA.
ChemInform Abstract: Sequential Multicomponent Synthesis of α‐Ketoimides, from Acyl Chlorides, Isocyanides, and Silver Salts of Carboxylic Acids. (2015)

Abstract The sequential three component reaction of acyl chlorides, isocyanides, and silver carboxylates affords moderately stable keto‐iminoanhydrides which spontaneously undergo a Mumm rearrangement to produce the target α‐ketoimides (IX) and (XI).
Charge recycling differential logic (CRDL) for low power application (1996)

A novel logic family, called charge recycling differential logic (CRDL), has been proposed and analyzed. CRDL reduces power consumption by utilizing a charge recycling technique with the speed comparable to those of conventional dynamic logic circuits. It has an additional benefit of improved noise margin due to inherently static operation. The noise margin problem of true single-phase-clock latch (TSPC) is also eliminated when a CRDL logic circuit is connected to it. Two swing-suppressed-input latches (SSILs), which are introduced for use with CRDL, have better performance than the conventional transmission gate latch. Moreover, a pipeline configuration with CRDL in a true two-phase clocking scheme shows completely race-free operation with no constraints on logic composition. Eight-bit Manchester carry chains and full adders were fabricated using a 0.8 /spl mu/m single-poly double-metal n-well CMOS technology to verify the relative performance of the proposed logic family. The measurement results indicate that about 16-48% improvements in power-delay product are obtained compared with differential cascode voltage switch (DCVS) logic.
1,3-Dipolar Cycloaddition Reactions of Munchnone and Sydnone Derivatives Obtained from 4,5,6,7-Tetrahydrothieno[3,2-c]pyridine-4 and -6-carboxylic Acids (1981)

The 1.3-dipolar cycloaddition of dimethyl acetylenedicarboxylate with rnesoionlc munchnonesand sydnones derived from 4.5.6.7-tetrahydrothieno(3.2-c)pyridine-4and -6 carboxylic acids afforded respectively new ringfused pyrroles and pyrazoles.The conversion of secondary amino aclds lnto pyrroles vla intermed~ate mesoionic 1.3-oxazolium-5dates (munchnones) l has been utilized in converting the "cyclic" amino acids, tetrahydro-P -carbo-2 3 4 line-land -3 carboxylic acids and tetrahydroisoquinoline-i and -3 ~a r b o x ~l ~c acids into novel ring-fused pyrroles.These reactions involved a 1.3-dipolar cycloadd~tion of the munchnone,behavir.g 5
Effects of Feeding Hexane-Extracts of a Shochu Distillery By-Product on Skeletal Muscle Protein Degradation in Broiler Chicken (2010)

We have found that shochu distillery by-product (SDBP) contains a growth promoting factor that can be extracted with ether. In the present study, we administered hexane-extracts of SDBP (HSDBP) to broiler chickens and observed changes in skeletal muscle protein degradation in order to clarify the mechanism of growth promotion due to SDBP feeding. The pectoralis superficial muscle weight was significantly increased by HSDBP feeding. Plasma N(tau)-methylhistidine concentration was significantly decreased by HSDBP, showing that the rate of muscle protein degradation decreased. It was also found that the expression of mRNA of ubiquitin-proteasome system and calpain was decreased by HSDBP. These results indicate that growth promotion due to SDBP is caused by suppression of skeletal muscle protein degradation, which is related to the ubiquitin-ptoteasome system and calpain.
The Level and Integrity of Synaptic Input Regulates Dendrite Structure (2006)

How localized synaptic input regulates dendritic branch structure is not well understood. For these experiments, we used single-cell electroporation, live cell imaging, in vitro deafferentation, pharmacology, and electrophysiological stimulation to study how local alterations in synaptic input affect dendritic branch structure in nucleus laminaris (NL). We found that interrupting or modulating synaptic input to distinct sets of NL dendrites can regulate their structure on a very short timescale. Specifically, eliminating synaptic input by deafferenting only one set of the bitufted NL dendrites caused a selective reduction in the total dendritic branch length of the deafferented dendrites but relatively few changes in the normally innervated dendrites on the same cell. An analysis of individual dendritic branch changes demonstrated that both control and deafferented NL dendrites exhibit branch extension and retraction. However, the presence of intact synaptic inputs balanced these changes, maintaining the total dendritic branch length of control dendrites. When glutamate receptor signaling was blocked (DNQX and AP-5), NL neurons exhibited significant dendrite retraction, demonstrating that NL dendrite maintenance depends in part on presynaptic glutamatergic input. Electrophysiological experiments further confirmed that modulating the level of synaptic input regulates NL dendrite structure. Differential stimulation of the two sets of dendrites resulted in a selective reduction in the total dendritic branch length of the unstimulated dendrites and a selective increase in the total dendritic branch length of the stimulated dorsal dendrites. These results suggest that balanced activation of the two sets of NL dendrites is required to maintain the relative amount of dendritic surface area allotted to each input.
The effects of polyvinyl chloride and polyolefin blood bags on red blood cells stored in a new additive solution (2001)

RBCs stored in PVC had markedly less haemolysis and higher RBC ATP concentrations than those stored in PO. Haemolysis would limit RBC storage in PO bags to a duration of 6 weeks, even with EAS-61.
FRIEND21 project (1991)

Article FRIEND21 project: a construction of 21st century human interface Share on Authors: Hajime Nonogaki FRIEND21 Research Center, Institute for Personalized Information Environment, 1-17-1 Toranomon, Minato-ku, Tokyo 105, Japan FRIEND21 Research Center, Institute for Personalized Information Environment, 1-17-1 Toranomon, Minato-ku, Tokyo 105, JapanView Profile , Hirotada Ueda FRIEND21 Research Center, Institute for Personalized Information Environment, 1-17-1 Toranomon, Minato-ku, Tokyo 105, Japan FRIEND21 Research Center, Institute for Personalized Information Environment, 1-17-1 Toranomon, Minato-ku, Tokyo 105, JapanView Profile Authors Info & Claims CHI '91: Proceedings of the SIGCHI Conference on Human Factors in Computing SystemsApril 1991 Pages 407–414https://doi.org/10.1145/108844.108978Published:01 March 1991 8citation329DownloadsMetricsTotal Citations8Total Downloads329Last 12 Months6Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Optical purification of racemic mixtures by laser distillation in the presence of a dissipative bath (2004)

Optical purification of a mixture of chiral molecules in the presence of dissipation is examined. Specifically, the case where dissipation occurs on timescales comparable to those of the laser pulses is treated. The interplay between a strong driving field and decoherence and the extent to which control is possible in the presence of dissipation and decoherence is elucidated.
Treatment of Automobile Shredded Residue by Kiln-type Pyrolysis and Melting Process (2001)

This paper reports on the results obtained by treating automobile shredded residue in a kiln-type pyrolysis and melting plant. The results are as follows. (1) The amount of recycled aluminum and ferrous metals was about nine times as much as obtained with conventional municipal solid waste (MSW) treatment. (2) Slag leaching performance was excellent and the release of six heavy metals such as Pb,Cr^<6+> satisfied soil environment regulations. No dioxin in slag was detected. Furthermore, metal-Fe content of slag was very low, which is advantageous for slag utilization in the civil engineering field. (3) Due to the high temperature combustion of the pyrolysis gas and recycled carbon at around 1300℃ and a 1.2 air excess ratio, the formation of dioxin was suppressed. Furthermore, as the result of feeding activated carbon to both fabric filters, dioxin emissions were below 0.01ng-TEQ/m^3N at the stack. (4) Although the amount of dechlorinating agent was increased to the fabric filter for high HCl content in the flue gas, bulk reduction of the waste to less than 1/38 was achieved, as compared with 1/200 for MSW treatment.
ChemInform Abstract: A Very Efficient, Short Synthesis of 6,7,8,8a‐Tetrahydropyrrolo(1,2‐a)pyrimidines from Imines via 4‐Amino‐1‐azabutadienes. (1989)

Abstract The ketimines (III), derived from 4‐aminobutyraldehyde acetal (II), are converted to the title compounds (V) by consecutive metalation, coupling with the nitriles (IV), and acid‐catalyzed cyclization.
Muon Background Studies for Beam Dump Operation of the K12 Beam Line at CERN (2019)

In the scope of the Physics Beyond Colliders study at CERN a future operation of the NA62 experiment in beam dump mode is discussed, enabling the search for dark sector particles, e.g. heavy neutral leptons, dark photons and axions. For this purpose, the 400 GeV/c primary proton beam, extracted from the SPS, will be dumped on a massive dump collimator located in the front end of the K12 beam line. Muons originating from interactions and decays form a potential background for this kind of experiment. To reduce this background, magnetic sweeping within the beam line is employed. In this contribution, the muon production and transport has been investigated with the simulation framework G4beamline. The high computational expense of the muon production has been reduced by implementing sampling methods and parametrizations to estimate the amount of high-energy muons and efficiently study optimizations of the magnetic field configuration. These methods have been benchmarked with measured data, showing a good qualitative agreement. Finally, first studies to reduce the muon background by adapting the magnetic field configuration are presented, promising a potential background reduction by a factor four.
Overexpression of HOXB7 and homeobox genes characterizes multiple myeloma patients lacking the major primary immunoglobulin heavy chain locus translocations (2011)

Homeobox (HOX) gene transcription factors are frequently deregulated in hematologic malignancies and involved in leukemogenic transformation [1]. Moreover, their overexpression has been associated with tumoral-induced neoangiogenesis in solid cancer [2]. The expression and the role of these genes have not yet been completely elucidated in multiple myeloma (MM). Recently, we reported that a small fraction of MM patients shows a HOXB7 overexpression as compared with normal samples and that HOXB7 expression correlates with bone marrow angiogenesis and the production of the proangiogenic factors by MM cells [3]. Other authors previously reported that HOXA cluster genes are expressed in a small fraction of MM patients [4]. Herein, we extended our previous evidences with the evaluation of the expression level of HOXB7 and the other gene family members in a large number of primary MM cells in relationship with the different molecular subgroups of MM and the presence of specific chromosome translocations. We found that HOXB7 and other genes of HOX family have a preferential distribution based on the characteristics of molecular MM subtypes based on the translocations/cyclins (TC) classification, suggesting a potential relationship between HOX genes expression, angiogenesis, and molecular features of MM patients.
Large Memory Layers with Product Keys (2019)

This paper introduces a structured memory which can be easily integrated into a neural network. The memory is very large by design and significantly increases the capacity of the architecture, by up to a billion parameters with a negligible computational overhead. Its design and access pattern is based on product keys, which enable fast and exact nearest neighbor search. The ability to increase the number of parameters while keeping the same computational budget lets the overall system strike a better trade-off between prediction accuracy and computation efficiency both at training and test time. This memory layer allows us to tackle very large scale language modeling tasks. In our experiments we consider a dataset with up to 30 billion words, and we plug our memory layer in a state-of-the-art transformer-based architecture. In particular, we found that a memory augmented model with only 12 layers outperforms a baseline transformer model with 24 layers, while being twice faster at inference time. We release our code for reproducibility purposes.