gebhart/patrepeval huggingface dataset:
THE LOW-TEMPERATURE ORDERED STATE OF CERIUM MAGNESIUM NITRATE AND ITS INFLUENCE ON NUCLEAR ORIENTATION (1964)

The method of Luttinger and Tisza for minimizing the dipole–dipole interaction energy is applied to cerium magnesium nitrate, and an antiferromagnetic ordering of the cerium spins at 0 °K is found. Using this configuration, the magnetic field at the divalent ions is calculated. Next, the anisotropy of γ rays from Co 60 aligned in this salt is calculated for temperatures below 0.003 °K. Qualitative agreement is found between these calculations and measurements of γ-ray anisotropy reported in the literature.
SPOC: GPGPU PROGRAMMING THROUGH STREAM PROCESSING WITH OCAML (2012)

General purpose computing on graphics processing units (GPGPU) consists of using GPUs to handle computations commonly handled by CPUs. GPGPU programming implies developing specific programs to run on GPUs managed by a host program running on the CPU. To achieve high performance implies to explicitly organize memory transfers between devices. Besides, different incompatible frameworks exist making productivity and portability difficult to achieve. In this paper, we describe SPOC, an OCaml library, defining specific data sets in order to automatically manage transfers between GPU and CPU. SPOC also offers a runtime library looking for multiple frameworks and making them usable transparently. We also describe the link between SPOC and the OCaml garbage collector to optimize transfers dynamically. SPOC benchmarks show that SPOC can offer great performance while simplifying GPGPU programming
Analysis of software rejuvenation using Markov Regenerative Stochastic Petri Net (2002)

In a client-server type system, the server software is required to run continuously for very long periods. Due to repeated and potentially faulty usage by many clients, such software "ages" with time and eventually fails. (Huang et al., 1995) proposed a technique called "software rejuvenation" in which the software is periodically stopped and then restarted in a "robust" state after proper maintenance. This "renewal" of software prevents (or at least postpones) the crash failure. As the time lost (or the cost incurred) due to the software failure is typically more than the time lost (or the cost incurred) due to rejuvenation, the technique reduces the expected unavailability of the software. We present a quantitative analysis of software rejuvenation. The behavior of the system is represented through a Markov Regenerative Stochastic Petri Net (MRSPN) model which is solved both for steady state as well as transient conditions. We provide a closed-form analytical solution for the steady state expected down time (and the expected cost incurred) due to system unavailability. We also evaluate the optimal rejuvenation interval which minimizes the expected unavailability of the software.
Effect of low dose daily aspirin on serum urate levels and urinary excretion in patients receiving probenecid for gouty arthritis. (2000)

Low dose daily enteric coated aspirin does not significantly interfere with the uricosuric effects of probenecid in patients with gouty arthritis.
Overflowing Continuous Cultures: a way to manage excess of foaming during the sustainable production of surfactant in reactors (2015)

International audience
Modeling, simulation, and optimization of bacterial leaching reactors (2000)

Bacterial leaching represents an unusual problem in biochemical engineering, because the substrate for bacterial growth is not supplied directly, but is a product of another reaction, the leaching of mineral particles. In addition, leaching is a heterogeneous reaction dependent on the particle-size distribution in the feed and on the kinetics of particle shrinkage. In this study, these effects are incorporated in the material balance for each mineral by the number balance. Examination of the number balance gives rise to a novel analysis of the competing technologies for leaching. The model is completed by the addition of material balances for the ferrous and ferric ions, the dissolved oxygen, and for each bacterial species to the number balance for each mineral present in the feed. The model is compared with pilot plant data for three different ores. It is shown that the model is in excellent agreement with the data. The performance of a bacterial leaching reactor is explored using the model, and the washout and sensitivity criteria are determined. It is shown that there are three washout conditions, in which the leaching conversion drops to zero. The washout conditions are dependent on the growth rate of the bacteria, on the rate of dissolution of the mineral, and on the rate of mass transfer of oxygen to the reactor. The critical washout condition is that arising from the rate of mineral dissolution. The optimization of a plant in which continuous tank reactors are configured in series is addressed. This analysis shows that the primary reactor should be between 1.5 and 2 times the size of each of the secondary reactors in a series combination. © 2001 John Wiley & Sons, Inc. Biotechnol Bioeng 71: 255–265, 2000/2001.
EzMail: using information visualization techniques to help manage email (2004)

Originally designed as a messaging application, email is now used for a wide range of functions. Email clients however have not progressed correspondingly to support users with email management. This work describes the design of EzMail, an email visualization tool that runs in conjunction with an email client and creates a multi-view interface to assist with email management. Our primary focus is to group and visualize messages as components of threads to provide contextual information and conversational history. We have developed visualizations for individual messages, message properties, and messages in a thread. Message annotation is incorporated, along with a capability for replying simultaneously to several messages. A small user survey and a user study provided information regarding users' management of their messages and threads, and a comparative evaluation of EzMail with respect to Microsoft Outlook.
Treatment (Evidence-based Medicine) of Drug-Induced Psychosis, Dementia, Depression and Anxiety in Idiopathic Parkinson Syndrome (2001)

Unter Berücksichtigung neuer Entwicklungen der Pharmakotherapie psychiatrischer Symptome und Komplikationen des überwiegend idiopathischen Parkinson-Syndroms wurden in einer Expertenrunde Therapieempfehlungen unter dem Prinzip der Evidence-Based Medicine (EBM) erarbeitet. In kurzen Skizzen werden diese übersichtsartig dargestellt.
IMMU-24. THE IMPACT OF BRAIN TUMORS ON HEMATOPOIETIC STEM CELL-DERIVED T CELLS (2018)

The T cell repertoire of brain tumor bearing hosts has been previously described to be skewed to have increased regulatory phenotype relative to healthy hosts (Woroniecka et al 2018). We have found that hematopoietic stem cells (HSCs) isolated from tumor bearing mice are inefficient at engraftment and reconstitution of the hematopoietic compartment, giving rise to less live cells than HSCs derived from healthy controls. We found that CD4+ splenocytes and CD8+ bone marrow-derived cells and splenocytes that arise from HSCs of tumor bearing hosts are polarized towards a terminal memory phenotype relative to HSCs derived from healthy hosts. We believe that this dysregulation in T cell reconstitution is a major player in mounting immune responses against CNS malignancies. Lineage negative HSCs were isolated from GFP transgenic healthy donors or DsRed transgenic tumor-bearing mice and adoptively transferred into C57BL/6 recipient cohort of lethally irradiated mice. HSCs are derived from DsRed or GFP transgenic mice to allow for tracking of HSC-derived populations. One month after transfer, mice are sacrificed and spleen, bone marrow, and blood are harvested and stained for flow cytometry. RESULTS & T cells derived from TB HSCs have a distinct phenotype compared to T cells from healthy HSCs, demonstrating intracranial brain tumors likely have an impact on HSC differentiation outcomes.
Statistical generalization: theory and applications (2002)

In this paper, we discuss a new approach to generalize heuristic methods (HMs) to new test cases of an application, and conditions under which such generalization is possible. Generalization is difficult when performance values of HMs are characterized by multiple statistical distributions across subsets of test cases of an application. We define a new measure called probability of win and propose three methods to evaluate it: interval analysis, maximum likelihood estimate, and Bayesian analysis. We show experimental results on new HMs found for blind equalization and branch-and-bound search.
Code Transformation by Direct Transformation of ASTs (2015)

Software evolves to be adapted to the environment, due to bugs, new features and design changes. Code transformations can be done manually, but that is a tedious and error-prone task. Therefore automated tools are used to assist developers in this maintenance operation.
A 2.8-7.5 PJ/PULSE HIGHLY-FLEXIBLE IMPULSE-RADIO ULTRA-WIDEBAND PULSE-GENERATOR (2014)

A low-power on-off-keying impulse-radio (IR) ultra-wideband (UWB) pulse generator (PG) intended for wireless-powered IR-UWB radio applications is presented. The proposed PG has high flexibility, the center frequency, output power and pulse-width (PW) are controllable depending on channel conditions and data rates. Qualitative frequency-domain and transient analyses are presented. A new figure-of-merit (FoM) is proposed such that a more precise comparison between different PGs can be made. The PG is successfully implemented in a TSMC 90 nm CMOS process, measurements show the energy consumption and FoM to be 2.8-7.5 pJ/pulse and 1.6-2.6% respectively. The output swing and PW are 277-329 mVp-p and 509-1088 ps respectively. The core area is 0.092 mm 2 .
Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau (2002)

The R406W tau mutation found in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) causes a hereditary tauopathy clinically resembling Alzheimer's disease. Expression of modest levels of the longest human tau isoform with this mutation under the control of the alpha-calcium-calmodulin-dependent kinase-II promoter in transgenic (Tg) mice resulted in the development of congophilic hyperphosphorylated tau inclusions in forebrain neurons. These inclusions appeared as early as 18 months of age. As with human cases, tau inclusions were composed of both mutant and endogenous wild-type tau, and were associated with microtubule disruption and flame-shaped transformations of the affected neurons. Straight tau filaments were recovered from Sarkosyl-insoluble fractions from only the aged Tg brains. Behaviorally, aged Tg mice had associative memory impairment without obvious sensorimotor deficits. Therefore, these mice that exhibit a phenotype mimicking R406W FTDP-17 provide an animal model for investigating the adverse properties associated with this mutation, which might potentially recapitulate some etiological events in Alzheimer's disease.
[Diagnosis of permethrin intoxication in the cat by use of a toxicological screening]. (2010)

Nachweis einer Permethrinvergiftung bei der Katze mithilfe des toxikologischen Screenings - Ein Fallbericht
Crosslinking during radical polymerization of dodecyl methacrylate (2000)

A much more efficient formation of crosslinks was observed in the free-radical polymerization of dodecyl methacrylate with respect to the amount of decomposed peroxide than it would correspond to the additional peroxide crosslinking of formed poly(dodecyl methacrylate). Polymer crosslinking also proceeds after using 2,2´-azoisobutyronitrile as initiator of the polymerization of dodecyl methacrylate, although with a substantially lower efficiency compared to the initiation by peroxide under comparable conditions. The efficient formation of crosslinked structures can be explained by branching and copolymerization of monomer with multifunctional dead polymer. Multifunctionality of the formed macromolecules is a result of transfer and addition reactions of the present free radicals with the formed polymer. The difference in the influence of the initiator follows from the higher reactivity of oxy radicals in transfer reactions with monomer dodecyl methacrylate which results in a greater number of polymerizable double bonds built in the polymer chain.
Depression Screening from Voice Samples of Patients Affected by Parkinson’s Disease (2019)

Depression is a common mental health problem leading to significant disability world wide. Depression is not only common but also commonly co-occurs with other mental and neurological illnesses. Parkinson's Disease gives rise to symptoms directly impairing a person's ability to function. Early diagnosis and detection of depression can aid treatment, but diagnosis typically requires an interview with a health provider or structured diagnostic questionnaire. Thus, unobtrusive measures to monitor depression symptoms in daily life could have great utility in screening depression for clinical treatment. Vocal biomarkers of depression are a potentially effective method of assessing depression symptoms in daily life, which is the focus of the current research. We have a database of 921 unique patients with Parkinson's disease and their self assessment of whether they felt depressed or not. Voice recordings from these patients were used to extract paralinguistic features, which served as inputs to machine-learning and deep learning techniques to predict depression. The results are presented here and the limitations are discussed given the nature of the recordings which lack language content. Our models achieved accuracies as high as 0.77 in classifying depressed and non-depressed subjects accurately using their voice features and PD severity. We found depression and severity of Parkinson's Disease had a correlation coefficient of 0.3936, providing a valuable feature when predicting depression from voice. Our results indicate a clear correlation between feeling depressed and the severity of the Parkinson's disease. Voice may be an effective digital biomarker to screen for depression among patients suffering from Parkinson's Disease.
A LYMPHOCYTOTOXICITY ASSAY NOT REQUIRING THE IN VITRO CULTURE OF TARGET TUMOR CELLS1 (1974)

A method is described which permitted the assessment of allogeneic cell-mediated immunity to tumor biopsies without an intervening period of tissue culture. Freshly excised tumor fragments were dissociated and labeled with 125IUdR. Sensitized or non-sensitized lymphocytes were mixed with tumor cells at an optimal ratio of 100:1. The mixed cell suspension was placed in diffusion chambers and inserted into the peritoneum of mice. Radioactivity was lost from the chambers only as a consequence of cell death. Approximately 5 days were required for demonstration of maximal lymphocytotoxicity. However, labeled target cells killed with heat lost all radioactivity within 24 hr. There was no detectable reutilization of label by adjacent living tumor cells. Target cells obtained directly from tumors were more easily killed by sensitized lymphocytes than target cells obtained from tissue cultures. The use of hosts allogeneic to both tumor cells and attacking lymphocytes did not interfere with the assay. These observations suggest the feasibility of this method for the assessment of tumor-specific immunity to human tumors. This approach should be especially useful in the study of immunity to human carcinomas which often resist successful establishment in cell cultures.
Rhodium-Catalyzed Asymmetric Hydro-formylation (2010)

Over the past decade, the Landis group has contributed consistently to the development of enantioselective rhodium-catalyzed ­hydroformylation (see Review below). The authors expand on their earlier work by applying the rhodium BisDiazaphos catalyst to vinyl carboxamides, allyl ethers, and allyl carbamates. The catalyst loading is low and an application of this strategy is demonstrated in the synthesis of the Roche aldehyde.
Red Flags: Barriers to Listening and Spoken Language in Children with Hearing Loss (2014)

To ensure optimal auditory development for the acquisition of spoken language, children with hearing loss require early diagnosis, effective ongoing audiological management, well fit and maintained hearing technology, and appropriate family-centered early intervention. When these elements are in place, children with hearing loss can achieve developmental and communicative outcomes that are comparable to their hearing peers. However, for these outcomes to occur, clinicians—early interventionists, speech-language pathologists, and pediatric audiologists—must participate in a dynamic process that requires careful monitoring of countless variables that could impact the child's skill acquisition. This paper addresses some of these variables or “red flags,” which often are indicators of both minor and major issues that clinicians may encounter when delivering services to young children with hearing loss and their families.
Titanium‐Catalyzed Intermolecular Hydroamination of Vinylarenes (2005)

The Lewis acid TiCl4 allows the intermolecular hydroamination of vinylarenes (see scheme). Some of the hydroamination products undergo rearrangements to give ortho-alkylated compounds. The catalyst tolerates a range of functional groups (R′=CF3, Cl, CN, F, Br) and provides the products in good yields. This method was also applied to the synthesis of a tetrahydroisoquinoline derivative.
A “Minimal” Sodium Channel Construct Consisting of Ligated S5-P-S6 Segments Forms a Toxin-activatable Ionophore (2002)

The large size (six membrane-spanning repeats in each of four domains) and asymmetric architecture of the voltage-dependent Na+ channel has hindered determination of its structure. With the goal of determining the minimum structure of the Na+ channel permeation pathway, we created two stable cell lines expressing the voltage-dependent rat skeletal muscle Na+ channel (micro1) with a polyhistidine tag on the C terminus (muHis) and pore-only micro1 (muPore) channels with S1-S4 in all domains removed. Both constructs were recognized by a Na+ channel-specific antibody on a Western blot. muHis channels exhibited the same functional properties as wild-type micro1. In contrast, muPore channels did not conduct Na+ currents nor did they bind [3H]saxitoxin. Veratridine caused 40 and 54% cell death in muHis- and muPore-expressing cells, respectively. However, veratridine-induced cell death could only be blocked by tetrodotoxin in cells expressing muHis, but not muPore. Furthermore, using a fluorescent Na+ indicator, we measured changes in intracellular Na+ induced by veratridine and a brevotoxin analogue, pumiliotoxin. When calibrated to the maximum signal after addition of gramicidin, the maximal percent increases in fluorescence (deltaF) were 35 and 31% in cells expressing muHis and muPore, respectively. Moreover, in the presence of 1 microm tetrodotoxin, deltaF decreased significantly to 10% in muHis- but not in muPore-expressing cells (43%). In conclusion, S5-P-S6 segments of micro1 channels form a toxin-activable ionophore but do not reconstitute the Na+ channel permeation pathway with full fidelity.
Semantic Segmentation of Highly Structured and Weakly Structured Images (2017)

Cette thèse pour but de développer des méthodes de segmentation pour des scènes fortement structurées (ex. bâtiments et environnements urbains) ou faiblement structurées (ex. paysages ou objets naturels). En particulier, les images de bâtiments peuvent être décrites en termes d'une grammaire de formes, et une dérivation de cette grammaire peut être inférée pour obtenir une segmentation d'une image. Cependant, il est difficile et long d'écrire de telles grammaires. Pour répondre à ce problème, nous avons développé une nouvelle méthode qui permet d'apprendre automatiquement une grammaire à partir d'un ensemble d'images et de leur segmentation associée. Des expériences montrent que des grammaires ainsi apprises permettent une inférence plus rapide et produisent de meilleures segmentations. Nous avons également étudié une méthode basée sur les auto-contextes pour segmenter des scènes fortement structurées et notamment des images de bâtiments. De manière surprenante, même sans connaissance spécifique sur le type de scène particulier observé, nous obtenons des gains significatifs en qualité de segmentation sur plusieurs jeux de données. Enfin, nous avons développé une technique basée sur les réseaux de neurones convolutifs (CNN) pour segmenter des images de scènes faiblement structurées. Un filtrage adaptatif est effectué à l'intérieur même du réseau pour permettre des dépendances entre zones d'images distantes. Des expériences sur plusieurs jeux de données à grande échelle montrent là aussi un gain important sur la qualité de segmentation
Adhesion‐Non Adhesion Behavior of Non‐Polar Solvent Based SiC Slurries for Electro‐Photographic Solid Freeform Fabrication Applications (2006)

This chapter contains sections titled: Introduction Experimental Procedure Results and Discussion Conclusions
The Odor Impact Model (1991)

(1991). The Odor Impact Model. Journal of the Air & Waste Management Association: Vol. 41, No. 10, pp. 1360-1362.
Hydrodynamic and mass transfer performance of multiple upcomer extraction trays (1997)

Abstract The multiple upcomer (MU) extraction tray was specifically developed for aromatics extraction processes. Hydro‐dynamic and mass transfer experiments have been carried out with n ‐butanol/succinic acid/water as an experimental system in a MU tray extraction column of 0.1 m diameter. The dispersed phase hold‐up, drop size and overall efficiency were measured and the hydrodynamic and mass transfer parameters were correlated. The flooding velocities and the overall efficiency predicted from the correlation for this column agreed well with the experimental data.
Toxicity of a fatty acid and ammonia: interactions with hypoglycemia and Krebs cycle inhibition. (1983)

In rats, hypoglycemia induced with insulin and Krebs cycle inhibition produced by fluoroacetate poisoning augmented the encephalopathic effects of octanoic acid and NH4Cl. Blood sugars in the range of 25 to 45 mg/dl resulted in a decrease of approximately 30% in the doses of NH+4 and of octanoate required to induce coma in otherwise normal rats. Mild fluoroacetate poisoning resulted in a corresponding decrease of 25% in the dose of NH+4 and 10% in the dose of octanoate. A single coma-inducing dose of octanoate or several subcoma doses resulted in blood sugar decrements of 50% or more within 1 to 3 hr. A combination of subcoma doses of octanoate and NH+4 had the same effect. Pretreatment with glucose prevented the hypoglycemia and blunted the encephalopathic response to octanoate. A single coma-inducing dose of NH+4 or several subcoma doses resulted in blood sugar increments of 50% or more within 1/2 to 5 hr.
Stereoselective Synthesis of Alcohols, XXXVII. Origins of Stereoselectivity in Reactions of α‐Substituted Allylboronates with Aldehydes (1991)

Abstract Rate constants for the addition of α‐substituted allylboronates 4 (XH, Cl, Br, OCH 3 , SCH 3 ] to aldehydes have been measured. The results have been used to differentiate between different models that have been advanced to account for the high proportion of (Z)‐configurated homoallyl alcohols 5 formed in allylboration reactions. Attempts have been made in this context to detect ate‐complex formation between benzylboronates and aldehydes.