gebhart/patrepeval huggingface dataset:
Ceramide-Protein Interactions Modulate Ceramide-Associated Lipotoxic Cardiomyopathy (2018)

Lipotoxic cardiomyopathy (LCM) is characterized by abnormal myocardial accumulation of lipids, including ceramide; however, the contribution of ceramide to the etiology of LCM is unclear. Here, we investigated the association of ceramide metabolism and ceramide-interacting proteins (CIPs) in LCM in the Drosophila heart model. We find that ceramide feeding or ceramide-elevating genetic manipulations are strongly associated with cardiac dilation and defects in contractility. High ceramide-associated LCM is prevented by inhibiting ceramide synthesis, establishing a robust model of direct ceramide-associated LCM, corroborating previous indirect evidence in mammals. We identified several CIPs from mouse heart and Drosophila extracts, including caspase activator Annexin-X, myosin chaperone Unc-45, and lipogenic enzyme FASN1, and remarkably, their cardiac-specific manipulation can prevent LCM. Collectively, these data suggest that high ceramide-associated lipotoxicity is mediated, in part, through altering caspase activation, sarcomeric maintenance, and lipogenesis, thus providing evidence for conserved mechanisms in LCM pathogenesis in mammals.
Magnetic dimers and trimers in the disordered $S=3/2$ spin system BaTi$_{1/2}$Mn$_{1/2}$O$_{3}$ (2012)

We report a structural/magnetic investigation by X-ray absorption spectroscopy (XAS), neutron diffraction, dc-susceptibility ($χ_{\mbox{dc}}$) and electron spin resonance (ESR) of the 12R-type perovskite BaTi$_{1/2}$Mn$_{1/2}$O$_{3}$. Our structural analysis by neutron diffraction supports the existence of structural trimers with chemically disordered occupancy of Mn$^{4+}$ and Ti$^{4+}$ ions, with the valence of the Mn ions confirmed by the XAS measurements. The magnetic properties are explored by combining dc-susceptibility and $X$-band ($9.4$ GHz) electron spin resonance, both in the temperature interval of $2\leq T\leq1000$ K. A scenario is presented under which the magnetism is explained by considering magnetic dimers and trimers, with exchange constants $J_{a}/k_{B}=200(2)$ K and $J_{b}/k_{B}=130(10)$ K, and orphan spins. Thus, BaTi$_{1/2}$Mn$_{1/2}$O$_{3}$ is proposed as a rare case of an intrinsically disordered $S=3/2$ spin gap system with a frustrated ground state.
Coupled rate-dependent superelastic behavior of shape memory alloy bars induced by combined axial-torsional loading: a semi-analytic modeling (2013)

In this article, the coupled thermomechanical response of superelastic shape memory alloy bars and tubes in combined tension and torsion is studied both analytically and experimentally. Using the Gibbs free energy as the thermodynamic potential and choosing appropriate internal state variables, a three-dimensional phenomenological macroscopic constitutive model for shape memory alloys is derived. Taking into account the effect of latent heat during the forward and reverse martensitic phase transformation, the appropriate form of the energy balance relation is obtained. The three-dimensional coupled relations for the energy balance in the presence of the internal heat flux and the constitutive equations are reduced to a two-dimensional form for the tension-torsion case. An explicit finite difference approach is utilized to discretize the governing boundary conditions of bars. An empirical expression for the free heat convection from the surface of a shape memory alloy bar was proposed and experimentally validated. Several sets of experiments were then carried out to evaluate the mechanical and thermal responses of the model for a shape memory alloy tube subjected to uniaxial, pure torsion and non-proportional tension and torsion loading–unloading conditions. The approach could be used in the design of shape memory alloy devices undergoing combined loads with high strain rates or in the fatigue design of shape memory alloy devices subjected to cyclic loading.
Approximating a MIMO, 1D Diffusion System to a Low Order, State-Space Form in Order to Facilitate Controller Design (2010)

Chemical distribution is an important factor in many biological systems, driving the phenomenon known as chemotaxis. In order to properly study the effects of various chemical inputs to an in vitro biological assay, it is necessary to have strict control over the spatial distribution of these chemicals. This distribution is typically governed by diffusion, which by nature is a distributed parameter system (DPS), dependent on both space and time. Much study and literature within the controls community has been devoted to DPS, whose dynamics are marked by partial differential equations or delays. They span an infinite-dimensional state-space, and the mathematical complexity associated with this leads to the development of controllers that are often highly abstract in nature. In this paper, we present a method of approximating these systems and expressing them in a manner that makes a DPS amenable to control using a very low order model. In particular, we express the PDE for one-dimensional chemical diffusion as a two-input, two-output state-space system and show that standard controllers can manipulate the outputs of interest, using pole placement and integral control via an augmented state model.
T-cell immunotherapy with a chimeric receptor against CD38 is effective in eradicating chemotherapy-resistant B-cell lymphoma cells overexpressing survivin induced by BMI-1 (2012)

2] There is an urgent clinical need to find therapeutics to treat patients with lymphoma cells overexpressing BMI-1 and survivin. Although in the pre-rituximab era (Rituximab, IDEC Pharmaceuticals, San Diego, CA, USA), the long-term remission rate for patients with diffuse large B-cell lymphoma (DLBCL) was 50-60%, the addition of rituximab has led to an enormous improvement in survival. As rituximab has more significantly improved the overall survival, event-free survival and progression-free survival of patients with non-germinal center B cell-type DLBCL, which have a poor prognosis, than those with germinal center B cell-type DLBCL, We previously developed T cells with a chimeric antigen receptor (CAR) against CD38 and reported that these CD38-specific T cells effectively eliminated B-cell lymphoma cells in vitro and in vivo. This is because CD38 is widely and highly expressed in B-cell lymphoma cells (40-50% of patients with the B-cell typed), e, thus investigated whether T cells bearing an anti-CD38-CAR exerted cytotoxicity against B-cell lymphoma cells expressing BMI-1 and survivin. Here we report that, the CD38-specific T cells efficiently eliminated chemotherapy-resistant B-lymphoma cells overexpressing BMI-1 and survivin, and propose that T-cell immunotherapy with CAR may be useful for treating refractory B-cell lymphoma.
Co-primary Spectrum Sharing for Inter-operator Device-to-Device Communication (2016)

The business potential of device-to-device (D2D) communication including public safety and vehicular communications will be realized only if direct communication between devices subscribed to different mobile operators (OPs) is supported. One possible way to implement inter-operator D2D communication may use the licensed spectrum of the OPs, i.e., OPs agree to share spectrum in a co-primary manner, and inter-operator D2D communication is allocated over spectral resources contributed from both parties. In this paper, we consider a spectrum sharing scenario, where a number of OPs construct a spectrum pool dedicated to support inter-operator D2D communication. OPs negotiate in the form of a non-cooperative game about how much spectrum each OP contributes to the spectrum pool. OPs submit proposals to each other in parallel until a consensus is reached. When every OP has a concave utility function on the box-constrained region, we identify the conditions guaranteeing the existence of a unique equilibrium point. We show that the iterative algorithm based on the OP's best response might not converge to the equilibrium point due to myopically overreacting to the response of the other OPs, while the Jacobi-play strategy update algorithm can converge with an appropriate selection of update parameter. Using the Jacobi-play update algorithm, we illustrate that asymmetric OPs contribute an unequal amount of resources to the spectrum pool; however, all participating OPs may experience significant performance gains compared with the scheme without spectrum sharing.
Analysis and synthesis of double-layerMOSFET networks for smart sensory systems (1998)

An analysis method to find the natural response of double-layer planar lattice networks is found and its stability discussed. Following the proposed approach, a new circuit able to perform feature extraction at the sensory level by means of a convolution with a Gabor-like kernel is synthesised. The circuit, based on MOS transistors working in the subthreshold region, has been simulated and successfully compared with theoretical expectations. Its main features are the compactness, low-power and full programmability of the convolutional kernel.
TRIM32 Senses and Restricts Influenza A Virus by Ubiquitination of PB1 Polymerase (2015)

Polymerase basic protein 1 (PB1) is the catalytic core of the influenza A virus (IAV) RNA polymerase complex essential for viral transcription and replication. Understanding the intrinsic mechanisms which block PB1 function could stimulate development of new anti-influenza therapeutics. Affinity purification coupled with mass spectrometry (AP-MS) was used to identify host factors interacting with PB1. Among PB1 interactors, the E3 ubiquitin ligase TRIM32 interacts with PB1 proteins derived from multiple IAV strains. TRIM32 senses IAV infection by interacting with PB1 and translocates with PB1 to the nucleus following influenza infection. Ectopic TRIM32 expression attenuates IAV infection. Conversely, RNAi depletion and knockout of TRIM32 increase susceptibility of tracheal and lung epithelial cells to IAV infection. Reconstitution of trim32-/- mouse embryonic fibroblasts with TRIM32, but not a catalytically inactive mutant, restores viral restriction. Furthermore, TRIM32 directly ubiquitinates PB1, leading to PB1 protein degradation and subsequent reduction of polymerase activity. Thus, TRIM32 is an intrinsic IAV restriction factor which senses and targets the PB1 polymerase for ubiquitination and protein degradation. TRIM32 represents a model of intrinsic immunity, in which a host protein directly senses and counters viral infection in a species specific fashion by directly limiting viral replication.
Graphene for Tunable Nanophotonic Resonators (2013)

Local electro-optic modulation of nanophotonic structures is important for many applications. Here, we show that one can achieve efficient tunability of the nanostructures by coupling them to graphene. The easy electrical control of graphene allows a large modulation of these graphene-clad nanophotonic devices. We describe electrostatic tuning of a metallic as well as a dielectric resonator coupled to graphene. A large change, both in resonator linewidth and resonance frequency is observed. The experimental data match the theory very well indicating that the changes in the resonator are solely coming due to graphene.
Hopping Mechanism of Hole Transport in SiO2 at Cryogenic Temperatures (1993)

Abstract On the basis of the small polaron conductivity conception the hole transport between localized states at cryogenic temperatures in SiO 2 is analyzed. The phonon‐hole coupling constant is determined. It is shown that the hopping probability increases exponentially with increasing energy difference Δ E between the initial and final states up to Δ E = 2.5 eV and then rapidly drops. It is shown that both field and time dependencies of the hole transport can be explained by the proposed model.
Study on Heat Emission Power and Image Processing of Active Heating Thermography Method for Detection of Concrete Spalling (2007)

To detect the spalling of the deteriorated concrete surface, active infrared thermography method using the Xenon-Arc Lamp heating system has already been developed. To simplify the heating device system and widen applicable condition, reduced heat emission power was applied to the inspection test on the existing reinforced concrete viaduct. According to the test result, spalling can be detected with the reduced heat emission power, but distinction between the part without deterioration and the spalled part came to be rather ambiguous. To solve the latter problem, a new infrared image processing method focused on the changing trend of the temperature distribution was developed and its availability was proved.
Molecular aspects of carcinogenesis in pancreatic cancer. (2008)

Advances in molecular genetics and biology have improved our perception of the pathogenesis of PCa. However, further studies are needed to better understand the fundamental changes that occur in PCa, thus leading to better diagnostic and therapeutic management.
ChemInform Abstract: Nucleophilic Substitution of Aromatic Halides with Amines Under High Pressure. (1988)

Abstract The p‐nitrohalobenzenes (I) are aminated with the primary or secondary amines (II) under high pressure to form the nitroanilines (III).
Vaccination with inhibin-α provides effective immunotherapy against testicular stromal cell tumors (2017)

Considering the lack of any alternative effective treatment for chemo- and radiation-resistant TSC tumors, our results provide for the first time a rational basis for immune-mediated control of these aggressive and lethal variants of testicular cancer.
Total Syntheses of Bengamides B and E (2001)

Total syntheses of the cytotoxic marine natural products bengamides B and E are described. Both bengamides are prepared via amide coupling of a protected polyhydroxylated lactone intermediate 9 with a suitably substituted aminocaprolactam intermediate. Lactone 9 is prepared in five steps from commercially available alpha-D-glucoheptonic gamma-lactone. The key reactions are a selective deprotection of a 1,2-acetonide in the presence of a 1,3-acetonide and an (E)-selective olefination of an unstable aldehyde using a gem-dichromium reagent. The bengamide B lactam intermediate 10 is prepared in seven steps from commercially available (5R)-5-hydroxy-L-lysine (12). The desired S-configuration at the gamma-OH lactam position is established using the Mitsunobu reaction.
Hydraulic Fracturing Advances (Available Only in Geoenvironmental Special Issue) (1997)

Removing contaminants trapped in clays and nonpermeable soils can be difficult if not impossible with traditional extraction methods. A look at four hydraulic fracturing case studies shows how advances in this field are opening up sites that resist conventional remediation. Early developments in permeable barrier technology focused on intercepting horizontally moving contaminant plumes with vertical structures, such as trenches, to economically treat large volumes of contaminated water in a plume. Contaminant source areas, however, have so far proved difficult to treat with permeable barrier technology due to a lack of construction methods for horizontal structures capable of stopping downward-moving contaminants. New developments in hydraulic fracturing make it possible to fill horizontal fractures with compounds that alter the chemical composition of the subsurface and treat hard-to-reach areas.
LEEDUS: A MICROMACHINING PROCESS FOR DIE-SCALE PATTERN TRANSFER IN CERAMICS WITH HIGH RESOLUTION AND THROUGHPUT (2004)

While ceramics are important materials for electronic and microsystem packaging, they are difficult to pattern lithographically. LEEDUS, a fabrication process combining lithography, electroplating, batch mode micro electro-discharge machining (EDM) and batch mode micro ultrasonic machining (USM), is presented in this paper. This technology provides diescale pattern transfer capability from lithographic masks onto ceramics, glass or other brittle materials. This is done by using the photomask to create an electroplating mold, then using the electroplated pattern as an electrode to EDM a hard metal tool, which is finally used in the USM of the ceramic substrate. A minimum feature size of 25m has been demonstrated on the glass-mica (Macor TM ) ceramic plate with a 4.5mm 4.5mm die size and 34m cutting depth using a stainless steel microtool. The machining rate in the demonstration was about 18m/min, and the tool wear ratio for the microtool was 6%. The average surface roughness was Ra 0.55m. Other process characteristics are also discussed.
Convergent biomimetic semisynthesis of disesquiterpenoid rumphellolide J (2022)

The convergent biomimetic gram-scale synthesis of disesquiterpenoid ester rumphellolide J is described. 4β,8β-Epoxycaryophyllan-5-ol was prepared in 67% yield (1.4 g) from naturally ambudant (-)-β-caryophyllene. (+)-Rumphellaoic acid A was obtained in 46% yield (2.2 g) from (-)-caryophyllene oxide. The synthesised (+)-rumphellaoic acid had an opposite specific rotation compared to that of (-)-rumphellaoic acid A isolated from nature, indicating possible occurrence of (+)-β-caryophyllene in <i>Rumphella antipathies</i> and <i>Psidium guajava</i>. Esterification of (+)-rumphellaoic acid A <i>via</i> acyl fluoride and alkoxide of 4β,8β-epoxycaryophyllan-5-ol gave rumphellolide J in 70% yield (1.65 g). The same structure for the synthesized product and natural isolate was proven despite the opposite specific rotation value of the intermediate acid. The short access to the terpenoids provides a material for further investigations of biological activities and valuable reference standards for the analysis of the chemical composition of various natural sources.
Abstract 16328: Residual Pulmonary Hypertension Persist Even in Patients With Successful MitraClip and Adversely Affect Heart Failure Events (2014)

Background: Pulmonary hypertension (PH) is common among patients requiring mitral valve treatment, and even mild PH adversely affect outcome. The aim of the study was to investigate the response of pulmonary artery pressure (PAP) in patients undergoing MitraClip and determine the prognostic effect of residual PH. Methods: From 2007 to 2013, 121 consecutive patients undergoing the MitraClip were retrospectively reviewed. Patients were categorized into two groups according to residual PH defined by post-procedural PAP obtained by transthoracic echocardiography. The primary endpoint was combined endpoints of all-cause mortality, left ventricular assist device implantation, shock, mitral valve surgery, New York Heart Association III-IV, re-hospitalization due to heart failure, new onset atrial fibrillation requiring hospitalization, ventricular arrhythmia, mechanical ventilation more than 48 hours, admission longer than two weeks. Patients with existing pulmonary disease or systemic disease affecting PAP were excluded. Results: Forty seven of 86 had residual PH. Patients with residual PH had higher pre-procedural PAP, and higher six months PAP than those without residual PH (pre-procedural, 50.3±13.4 vs 42.2±9.8 mmHg, p=0.003; at six months, 45.4±14.0 vs 34.7±9.9 mmHg, p&lt;0.001, respectively). Patients without residual PH had an immediate decrease in PAP (42.2±9.8 vs 31.5±5.9 mmHg, p&lt;0.001), while patients with residual PH had a decrease in PAP at a month, but not a significant change immediate post-procedure (pre- to post-procedure, 50.3±13.4 to 49.7±7.2 mmHg p=0.808; post-procedure to a month, 49.7±7.2 to 43.3±10.3 mmHg, p&lt;0.001). Primary combined endpoint at two years met 26.5%. The Kaplan-Meier Curve (Log rank method) showed patients with residual PH had poorer outcome on primary endpoint (p=0.017). The independent predictor of the primary endpoint evaluated by multivariate analysis (Cox proportional hazard) was post-procedural PH [hazard ratio 2.9, 95% confidence interval 1.1-7.9]. Conclusion: Patients with residual PH have higher rate of adverse events associated with heart failure even with successful MR reduction, and additional medical intervention, such as pulmonary vasodilator, should be considered.
Bubble instabilities and transition to streamers in liquid dielectrics (2002)

The paper deals with the dynamics of a bubble initiated in the vicinity of an electrode in a liquid dielectric gap submitted to an electric field, and to the conditions leading to the generation of a streamer at its interface. By taking into account the surface tension of the bubble and the electrical charge that it carries, we establish a mathematical expression describing the shape of the bubble and allowing to analyze its deformation in function of the experimental conditions. The frequency of the disturbances at the interface is studied and the zone at which the local electric field is the highest is determined. It is shown that according to this frequency then to the value of the local electric field, different structures can be generated. An example of the topology of the disturbed interface is given and discussed.
Impaired VE-Cadherin/β-Catenin Expression Mediates Endothelial Cell Degeneration in Dilated Cardiomyopathy (2003)

These results indicate for the first time that the EC survival is impaired in myocardium of patients with DCM involving VE-cadherin/beta-catenin, probably independent of VEGF. Targeting VE-cadherin might be of benefit to counteract the selective EC pathology in DCM.
Bayesian Regularized Gaussian Mixture Regression with Application to Soft Sensor Modeling for Multi-Mode Industrial Processes (2018)

The Gaussian mixture regression (GMR) is an effective approach to predict those difficult-to-measure quality variables for industrial processes with multiple operating modes. However, the GMR easily gets stuck into overfitting in the scenario of insufficient labeled samples, particularly when the dimensionality of the secondary variables is high. To alleviate this issue, this paper proposes the Bayesian regularized GMR (BGMR), and applies it to soft sensor modeling. In the BGMR, an alternative model structure, which explicitly considers the functional dependency between the primary and secondary variables, is presented to facilitate the Bayesian regularization that is widely used for anti-overfitting. In addition, an efficient learning procedure is developed for the BGMR based on the expectation-maximization algorithm. The performance of the BGMR is evaluated through two case studies including a numerical example and a real-life industrial process, which demonstrates the effectiveness of the proposed approach.
Introduction to Meta‐analysis for Diagnostic Accuracy Studies (2011)

This chapter contains sections titled: Objectives Retrieval of the Literature Inclusion/Exclusion Criteria Extracting Information from the Literature Statistical Analysis Public Presentation
A Super-Resolution Mapping Using a Convolutional Neural Network (2019)

In this paper, we propose an approach for super-resolution land cover mapping on remote sensing images based on a Convolutional Neural Network (CNN). Here, the CNN is trained to match the input subimages to the super resolution map around the training pixels. Since there are so many possible configurations of super-resolution map on a given set of pixels, a large number of training samples are required. To reduce the number of training samples, we converted the super-resolution to a set of level set functions and used the minimum mean square error between the predicted and actual level set functions as the training objective. The QUICKBIRD satellite image data cover a part of Kasetsart University's Bangkhen campus was used for evaluation. Experimental results showed that the proposed method has achieved superior accuracy than both Hopfield and Pixel-Swapping methods.