gebhart/patrepeval huggingface dataset:
[Etiopathogenic characteristics of posterior uveitis in children]. (1994)

Nine children with acute posterior uveitis were treated for period of 3 years (3.2% of all children treated during that period). The authors speak in favor of the investigation of the HLA-system and the analysis of humoral and cellular immunologic parameters. In this study they present the relationship between these characteristics and the clinical diagnosis. Three of 9 children have with eye diseases associated HLA-B5 and HLA-B12 antigens and grave consequences for the sight of both eyes already as children. The results of immunologic tests in the examined group compared to the control group differ significantly in the total number of lymphocytes, total number of B lymphocytes and serum values of IgG, as well as C3 values of complement component (P < 0.05). Seen in percentage, however, the ratio of T to B lymphocytes, as well as the total number of leukocytes don't show significant differences. We consider that a proper and well-aimed history and complete etiologic detection according to the protocol have contributed to a clearer understanding and better insight into the prognosis of our patients.
Implementation and performance analysis of QAM modulator applicable to the HFC network (2016)

In this paper, we present an analysis of implemented QAM modulator in HFC network. It may be through the 256 QAM modulation using a single carrier to transmit data up to 38.8 Mbps. 64/256-QaM modulator based on ITU-T J.83 Annex B is implemented as a board which includes field programmable gate arrays (FPGAs). Implemented Modulator consists of RS-TCM encoder, a QAM modulator and Digital to analog converter (DAC). We analyze the received MPEG-2 TS stream and measured Program Clock Reference (PCR) jitter. TS stream is normally being received, PCR was confirmed to operate reliably within approximately -50 to +300 ns.
Rapidly degraded terpolymers of DL‐lactide, glycolide, and ϵ‐caprolactone with increased hydrophilicity by copolymerization with polyethers (1990)

A series of 66 terpolymers of dl-lactide, glycolide, and epsilon-caprolactone was synthesized for the purpose of identifying those materials which exhibited rapid degradation in vitro. Polymers having half-lives from a few weeks to several months were identified. The morphology of each material was characterized by differential scanning calorimetry. A terpolymeric composition of 60% glycolide, 30% dl-lactide, and 10% epsilon-caprolactone, which exhibited a half-life of 17 days, was selected for further investigation. The hydrophilicity of this material was increased by performing the polymerization in the presence of a polyether prepolymer, Pluronic F-68, with the motivation of concomitantly reducing cell and tissue adhesion. An increase in the hydrophilicity of the material was apparent from contact angle measurements. Copolymerization with the prepolymer also resulted in a stronger and partly crystalline material which was mechanically stable at physiological temperature in water. A slight increase was observed in the half-life of the polymer relative to the base polymer due to the presence of the prepolymer.
Shape-Morphing Materials from Stimuli-Responsive Hydrogel Hybrids (2017)

The formation of well-defined and functional three-dimensional (3D) structures by buckling of thin sheets subjected to spatially nonuniform stresses is common in biological morphogenesis and has become a subject of great interest in synthetic systems, as such programmable shape-morphing materials hold promise in areas including drug delivery, biomedical devices, soft robotics, and biomimetic systems. Given their ability to undergo large changes in swelling in response to a wide variety of stimuli, hydrogels have naturally emerged as a key type of material in this field. Of particular interest are hybrid systems containing rigid inclusions that can define both the anisotropy and spatial nonuniformity of swelling as well as nanoparticulate additives that can enhance the responsiveness and functionality of the material. In this Account, we discuss recent progress in approaches to achieve well-defined shape morphing in hydrogel hybrids. First, we provide an overview of materials and methods that facilitate fabrication of such systems and outline the geometry and mechanics behind shape morphing of thin sheets. We then discuss how patterning of stiff inclusions within soft responsive hydrogels can be used to program both bending and swelling, thereby providing access to a wide array of complex 3D forms. The use of discretely patterned stiff regions to provide an effective composite response offers distinct advantages in terms of scalability and ease of fabrication compared with approaches based on smooth gradients within a single layer of responsive material. We discuss a number of recent advances wherein control of the mechanical properties and geometric characteristics of patterned stiff elements enables the formation of 3D shapes, including origami-inspired structures, concatenated helical frameworks, and surfaces with nonzero Gaussian curvature. Next, we outline how the inclusion of functional elements such as nanoparticles can enable unique pathways to programmable and even reprogrammable shape-morphing materials. We focus to a large extent on photothermally reprogrammable systems that include one of a variety of additives that serve to efficiently absorb light and convert it into heat, thereby driving the response of a temperature-sensitive hydrogel. Such systems are advantageous in that patterns of light can be defined with very high spatial and temporal resolution in addition to offering the potential for wavelength-selective addressability of multiple different inclusions. We highlight recent advances in the preparation of light-responsive hybrid systems capable of undergoing reprogrammable bending and buckling into well-defined 3D shapes. In addition, we describe several examples where shape tuning of hybrid systems enables control over the motion of responsive hydrogel-based materials. Finally, we offer our perspective on open challenges and future areas of interest for the field.
The Power of the Supreme Court in the Age of the Positive State: A Preliminary Excursus. Part Two: On the Need for Adaptation to Changing Reality (1967)

Arthur Selwyn Miller, Alan W. Scheflin, The Power of the Supreme Court in the Age of the Positive State: A Preliminary Excursus. Part Two: On the Need for Adaptation to Changing Reality, Duke Law Journal, Vol. 1967, No. 3 (Jun., 1967), pp. 522-551
Characterisation and performance of a Terfenol-D coated femtosecond laser inscribed optical fibre Bragg sensor with a laser ablated microslot for the detection of static magnetic fields (2010)

We present a novel device for the characterisation of static magnetic fields through monitoring wavelength shifts of femtosecond inscribed fibre Bragg grating and micromachined slot, coated with Terfenol-D. The device was sensitive to static magnetic fields and can be used as a vectoral sensor for the detection of magnetic fields as low as 0.046 mT with a resolution of ± 0.3mT in transmission and ± 0.7mT in reflection. The use of a femtosecond laser to both inscribe the FBGs and micromachine the slot in a single stage prior to coating the device significantly simplifies the fabrication.
Submillisecond Elastic Recoil Reveals Molecular Origins of Fibrin Fiber Mechanics (2020)

Fibrin fibers form the structural scaffold of blood clots. Thus, their mechanical properties are of central importance to understanding hemostasis and thrombotic disease. Recent studies have revealed that fibrin fibers are elastomeric despite their high degree of molecular ordering. These results have inspired a variety of molecular models for fibrin’s elasticity, ranging from reversible protein unfolding to rubber-like elasticity. An important property that has not been explored is the timescale of elastic recoil, a parameter that is critical for fibrin’s mechanical function and places a temporal constraint on molecular models of fiber elasticity. Using high-frame-rate imaging and atomic force microscopy-based nanomanipulation, we measured the recoil dynamics of individual fibrin fibers and found that the recoil was orders of magnitude faster than anticipated from models involving protein refolding. We also performed steered discrete molecular-dynamics simulations to investigate the molecular origins of the observed recoil. Our results point to the unstructured αC regions of the otherwise structured fibrin molecule as being responsible for the elastic recoil of the fibers.
Inhibition of creatine kinase activity by 3‐butyl‐1‐phenyl‐2‐(phenyltelluro)oct‐en‐1‐one in the cerebral cortex and cerebellum of young rats (2010)

In the present study, we investigated the potential in vitro toxicity of the tellurium compound 3-butyl-1-phenyl-2-(phenyltelluro)oct-en-1-one on creatine kinase activity in cerebral cortex and cerebellum of 30-day-old Wistar rats. First, enriched mitochondrial and cytosolic fractions from the two tissues were pre-incubated for 30 min in the presence or absence of 1, 5 or 20 microm of organotellurium and the creatine kinase activity was measured. The organochalcogen reduced creatine kinase activity in a concentration-dependent pattern in the two tissues studied. Furthermore, the enzyme activity was performed after pre-incubation for 30, 60 or 90 min in the presence of 5 microm of the organotellurium. The compound inhibited creatine kinase activity in a time-dependent way in the enriched mitochondrial fraction of both tissues, but not in the cytosolic fraction, indicating different mechanisms for the organochalcogen in the mitochondrial and in the cytosolic creatine kinase. Pre-incubation of tellurium compound with reduced glutathione suggests that creatine kinase activity inhibition might be caused by direct interaction with thiol groups or by oxidative stress. Our findings suggest that creatine kinase inhibition may be one of the mechanisms by which this organotellurium could cause toxicity to the rat brain.
Ultra-Compact Optical Module of Homodyne Detection (2011)

We demonstrated ultra-compact and low-cost implementation of homodyne detection. The assembled module size was 10 × 30 mm2. Jitter of the attenuated BD-R readout signals was improved from 15% to 7.8% by applying the module.
Web-like domain structure formation in barium titanate single crystals (2010)

The evolution of ferroelectric domain structure in Remeika-grown BaTiO3 crystals under an inhomogeneous electric field has been investigated using piezoresponse force microscopy. The ac imaging bias was found to affect the metastable polarization state and lead to the formation of a web-like domain structure. It is suggested that this behavior is due to the existence of subsurface domains arising in single crystals with a layered structure.
PIG-W Is Critical for Inositol Acylation but Not for Flipping of Glycosylphosphatidylinositol-Anchor (2003)

Many cell surface proteins are anchored to a membrane via a glycosylphosphatidylinositol (GPI), which is attached to the C termini in the endoplasmic reticulum. The inositol ring of phosphatidylinositol is acylated during biosynthesis of GPI. In mammalian cells, the acyl chain is added to glucosaminyl phosphatidylinositol at the third step in the GPI biosynthetic pathway and then is usually removed soon after the attachment of GPIs to proteins. The mechanisms and roles of the inositol acylation and deacylation have not been well clarified. Herein, we report derivation of human and Chinese hamster mutant cells defective in inositol acylation and the gene responsible, PIG-W. The surface expressions of GPI-anchored proteins on these mutant cells were greatly diminished, indicating the critical role of inositol acylation. PIG-W encodes a 504-amino acid protein expressed in the endoplasmic reticulum. PIG-W is most likely inositol acyltransferase itself because the tagged PIG-W affinity purified from transfected human cells had inositol acyltransferase activity and because both mutant cells were complemented with PIG-W homologs of Saccharomyces cerevisiae and Schizosaccharomyces pombe. The inositol acylation is not essential for the subsequent mannosylation, indicating that glucosaminyl phosphatidylinositol can flip from the cytoplasmic side to the luminal side of the endoplasmic reticulum.
Analysis of EDS spectra of titanium dioxide coated TEC-8 conductive glass: Modeling diffusion in the photoanode of dye sensitized solar cells (2012)

The photoanode of a dye sensitized solar cell (DSSC) is typically a mesoporous titanium dioxide thin film adhered to a conductive glass plate. In the case of TEC-8 glass, an approximately 700 nm film of tin oxide provides the conductivity of this substrate. During the calcining step of photoanode fabrication, tin diffuses into the other layers. SEM and Electron Dispersion Microscopy are used to analyze the spreading of tin through the photoanode. The transport of tin is described using Fick's Law of Diffusion through a semi-infinite medium with a fixed tin concentration at the interface. Preliminary data suggest that this diffusion follows the Arrhenius model for diffusion in solids. However a semi-infinite model may be needed for the finite TiO2 layer. At temperatures (400 to 600 C) and times (30 to 90 min) typically employed in the calcinations of titanium dioxide layers for dye sensitized solar cells, the variation of the tin thickness may be affecting the resistance of the photoanode.
“Designing high-performance nighttime thermoradiative systems for harvesting energy from outer space” by Zhang et  al.: comment (2021)

The current-voltage characteristics presented by Zhang et al. in their recent work on designing thermoradiative systems overestimate the achievable power using the proposed material by several orders of magnitude.
Diameter of Erdős–Rényi graphs (2009)

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Parallel index building in Informix OnLine 6.0 (1992)

No abstract available.
Wall teichoic acids prevent antibody binding to epitopes within the cell wall of Staphylococcus aureus (2015)

Staphylococcus aureus is a Gram-positive bacterial pathogen that produces a range of infections including cellulitis, pneumonia, and septicemia. The principle mechanism in antistaphylococcal host defense is opsonization with antibodies and complement proteins, followed by phagocytic clearance. Here we use a previously developed technique for installing chemical epitopes in the peptidoglycan cell wall to show that surface glycopolymers known as wall teichoic acids conceal cell wall epitopes, preventing their recognition and opsonization by antibodies. Thus, our results reveal a previously unrecognized immunoevasive role for wall teichoic acids in S. aureus: repulsion of peptidoglycan-targeted antibodies.
A New Tire Model for Vehicle NVH Analysis (1987)

&lt;div class="htmlview paragraph"&gt;Since road roughness is an important source of vehicle vibration, a system model for NVH analysis requires a tire model which accurately predicts spindle response to road input. Most tire models currently used in the auto industry do not meet this requirement, because they are based on static stiffness of the tire and do not produce realistic response to input at the patch. This paper investigates a new modal tire model with patch input capability as a component within a vehicle system model. Comparisons are also presented between the behavior of the new tire model and a conventional spring model. To validate the performance of the tire model for NVH analysis, simulated vehicle responses to bump input are compared to chassis roll test results. Good correlation between the model prediction and the chassis roll measurements is observed.&lt;/div&gt;
Receiver Front-End Circuits for Future Generations of Wireless Communications (2008)

In this paper, new receiver concepts and CMOS circuits for future wireless communications applications are introduced. The concepts derived are applied to a few classes of wireless communications standards that are broad-band at radio frequencies and/or require a broad-band baseband circuitry. Multimode multiband operation and adaptivity as key requirements for future generation receivers are highlighted throughout the paper. The tradeoffs between power consumption, noise figure and linearity performance of low-noise amplifiers, mixers, and intermediate frequency filters are considered too.
Allosteric Communication across the Native and Mutated KIT Receptor Tyrosine Kinase (2012)

A fundamental goal in cellular signaling is to understand allosteric communication, the process by which signals originated at one site in a protein propagate dependably to affect remote functional sites. Here, we describe the allosteric regulation of the receptor tyrosine kinase KIT. Our analysis evidenced that communication routes established between the activation loop (A-loop) and the distant juxtamembrane region (JMR) in the native protein were disrupted by the oncogenic mutation D816V positioned in the A-loop. In silico mutagenesis provided a plausible way of restoring the protein communication detected in the native KIT by introducing a counter-balancing second mutation D792E. The communication patterns observed in the native and mutated KIT correlate perfectly with the structural and dynamical features of these proteins. Particularly, a long-distance effect of the D816V mutation manifested as an important structural re-organization of the JMR in the oncogenic mutant was completely vanished in the double mutant D816V/D792E. This detailed characterization of the allosteric communication in the different forms of KIT, native and mutants, was performed by using a modular network representation composed of communication pathways and independent dynamic segments. Such representation permits to enrich a purely mechanistic interaction-based model of protein communication by the introduction of concerted local atomic fluctuations. This method, validated on KIT receptor, may guide a rational modulation of the physiopathological activities of other receptor tyrosine kinases.
Interaction of albumin with the endothelial cell surface (2002)

Endothelial cells (EC) are covered with cell-borne proteoglycans and glycoproteins. Blood plasma proteins (e.g., albumin) adsorb to this glycocalyx forming a complex endothelial surface layer (ESL). We determined the molecular mobility of albumin by electron spin resonance (ESR) in the presence and absence of ECs to analyze interactions with the ESL. Albumin was spin labeled with 5- or 12-4,4-dimethyloxazolidine-N-oxyl (DOXYL)-stearic acid yielding information on the mobility of the molecular surface (5-DOXYL) or the entire protein (12-DOXYL). EC cultures grown on glass coverslips were immersed in labeled albumin and placed in the temperature-regulated cavity of an ESR spectrometer. Alternatively, ECs were labeled and then exposed to native albumin. At 37 degrees C, rotational correlation times determined by modified saturation transfer ESR (ST-ESR) were 26 and 48 ns for 5-DOXYL- and 12-DOXYL-labeled albumin, respectively. Presence of ECs increased rotational correlation time values for 5-DOXYL-stearic acid to 37 ns but not for 12-DOXYL-stearic acid. Albumin was able to completely take up the label from labeled EC within 2 min. The present study shows that modified ST-ESR can be used to determine the mobility of biological macromolecules interacting with cellular surfaces. Reduction in albumin surface mobility in the presence of EC at unchanged mobility of protein proper and fast removal of labeled fatty acids from EC membranes indicate rapid transient interactions between albumin surface and ESL but no rigid incorporation of albumin into a macromolecular network that would interfere with its transport function for poorly water-soluble substances.
Simple approach for statistical modeling of process impacts on CMOS device variations in VLSI applications (2010)

A novel methodology to statistically analyze the statistics on small device performance is presented for the first time. To verify the accuracy of analysis and modeling, TCAD simulation is used to mimic possible process-induced and random fluctuations. The proposed approach precisely decouples various process dependency of the device electric behavior and predicts the device performance trend induced by these variables.
Polymerization and Calcium Binding of the Tubulin-colchicine Complex in the GDP State (2003)

The tubulin-colchicine complex instead of tubulin was used in an imidazole buffer throughout experiments. The interaction with calcium was examined, especially in the GDP state. The high affinity sites of calcium took part in the polymerization of the complex in the GTP state, while the low ones participated in the depolymerization. The complex had 2 high affinity sites with the dissociation constant of 11.5 x 10(-6) M, and 16 low affinity sites with the dissociation constant of 2.27 x 10(-4) M in the GTP state. In the case of GDP state, the dissociation constant of the high affinity site was 7.2 x 10(-6) M, and the low affinity site was not observed. The ultracentrifugal experiment indicated a little compact structure in the GTP state compared with the GDP state. This agreed with the results of calcium binding.
A 1.8 GHz highly-tunable low-phase-noise CMOS VCO (2002)

A 1.8 GHz fully integrated Voltage Controlled Oscillator (VCO) is presented. Through inductor optimization, the phase noise is as low as -127.5 dBc/Hz at 600 kHz and -142.5 dBc/Hz at 3 MHz. A 28% wide tuning range is achieved with a 1.8 V power supply. The VCO exceeds the DCS-1800 phase noise requirements with at least 4 dB over the whole DCS-1800 frequency band. The VCO is implemented in a 2-metal layer, 0.25 /spl mu/m standard CMOS technology, using no external components nor additional processing steps.
Nontraumatic pediatric musculoskeletal MR imaging: comparison of conventional and fast-spin-echo short inversion time inversion-recovery technique. (1995)

FSE-STIR can replace STIR when an inversion-recovery fat-suppression sequence is desired. Considerable imaging time is saved.
The organization of bilingual perceptual consonant space: English/Spanish bilingual perception of Malayalam nasal consonants (2006)

This study examines the capacity of English/Spanish bilinguals to discriminate between consonants that exist in only one of their respective phonetic inventories. Two non-native nasal consonant contrasts were tested: dental versus alveolar and the palatal versus velar, both found in Malayalam. The dental and palatal nasals appear in Spanish, while the alveolar and velar nasals occur in English. Poorer performance in discrimination was interpreted as indicative of a common nasal category subsuming the Spanish dental and English alveolar nasals; better performance was taken as evidence of the maintenance of separate categories from both languages. Two other tests were administered to aid in the interpretation of the discrimination test scores: forced-choice identification and perceptual similarity ratings. The findings of this research will be used to characterize the perceptual consonant space in terms of continuum between two possible bilingual systems: one that collapses similar categories across languages or one that maintains two distinct phonological systems that can be accessed simultaneously. It is believed that bilinguals will be able to discriminate between these contrasts more consistently than their monolingual peers; however, there is no prediction about performance relative to the monolingual group from Malayalam.