gebhart/patrepeval huggingface dataset:
Vacuum-assisted selective adhesive imprinting for heterogeneous system integration of MOEMS devices : Automated assembly of miniaturized PM sensor (2019)

In this paper we propose the selective adhesive bonding technique using contact imprinting from thin adhesive layers spin-coated on the sacrificial polyethylene foils. The imprinting is assisted with vacuum release of the polymer foil to reduce the pull-off adhesive force and prevent sticking, posing less constraints on the required lifting force. We apply this method in assembly of a highly integrated optical particle counter confronted with several strict assembly requirements, such as selective bonding with small feature size (<; 200 μm), minimal adhesive thicknesses (<; 15μm), precise out-of plane tolerances, low adhesive squeeze-out and hermetically sealed packaging. A successful selective adhesive bonding with ratio of vacuum tool area to adhesive contact area of 1:20 was demonstrated.
Video watermarking scheme resistant to geometric attacks (2003)

The robustness against geometrical attacks remains one of the most challenging issues in watermarking of images and video. This paper presents several improvements of the video watermarking approach presented in Haitsma et al. (2001), namely (i) using a temporally low-pass watermark and (ii) synchronization to resist attacks along the temporal axis. In order to improve the watermark detection performance, we propose to use an amplitude-limiting filter and a whitening filter during the watermark extraction process. Experimental results show that the proposed techniques achieve good performance.
Mid-Infrared Supercontinuum Generation in Germanium Waveguides (2021)

On-chip mid-infrared (mid-IR, from 3 to 15 μm wavelength) supercontinuum (SC) generation is of great interest for integrated sensing devices, since it enables parallel detection of multiples species [1] . The generation of mid-IR SC in group IV platforms is particularly significant, since it would allow low-cost, large-scale production and electro-optic integration. Mid-IR SC generation has been demonstrated in several group-IV platforms [1] – [4] . Recently, the wide transparency window up to 15 μm and theoretical predictions of attractive nonlinear properties [5] led researchers to explore germanium as a promising material for mid-infrared photonics. However, experimental SC generation in pure germanium waveguides remained elusive so far. Our group reported SC generation up to 8.5 μm in silicon-germanium on silicon waveguides [3] . We have also demonstrated the possibility, with this platform, of precisely controlling the SC coherence properties [6] – [8] . The great potential of germanium-based platforms for on-chip mid-IR SC generation was recently confirmed, with the demonstration of a SC extending from 3 up to 13 μm in a germanium-rich graded index silicon-germanium on silicon waveguide [9] . To achieve such a broad spectrum, however, the waveguide was pumped at 7.5 μm, whereas short wavelength pumps are preferable in fully integrated broadband sources.
Effect of Presteaming On Drying Stresses of Red Oak Using A Coating and Bending Method (1994)

This study was initiated to investigate the effect of presteaming on drying stresses of red oak ( Quercus sp.) using the coating and bending method. Besides the presteaming effect, a directional effect on drying stresses was also tested. Four blocks were randomly selected. Each block was divided into two pairs (four samples). One pair was randomly assigned to steaming while the other was assigned to control. A statistical split-plot model was used to analyze the results. Presteaming increased drying stress by up to 36% and decreased drying time by 23% when red oak was dried at 75% relative humidity and 44 C from average moisture content of 80 to 16%. The maximum drying stress of the steamed samples occurred before that of the unsteamed samples due to faster moisture loss from the sample. This study indicated that the coating and bending method could be used to study drying stresses of red oak. The statistical model revealed the differences between steaming and control and between inner and outer directions. Drying stresses were different in two opposite directions (outward and inward), regardless of whether the wood was steamed or not.
High-Frequency Pressure Measurements for Unstart Detection in Scramjet Isolators (2010)

This paper describes an experimental investigation using an array of high-frequency pressure transducers located in the isolator/combustor region of a direct-connect hydrocarbon-fueled, scramjet combustor. Isolator/combustor entrance conditions were fixed and representative of a Mach-5.5 flight condition. Mean, standard deviation, and spectral content of measured pressures were similar to those measured in previous studies. A simple model relating the sum of measured pressures and the fuel flow rate delivered to the primary injectors was developed. Pressure measurements were post-processed and evaluated for use in a shock-position-control sensor to detect engine unstart. Four methods of post-processing the pressure data and corresponding detection criteria were evaluated: a) 150% pressure rise, b) 150% increase in standard deviation, c) 150% increase in power spectral density (PSD), and d) summation of pressures. Pressure summation typically provided 1 – 2 s more lead time in detecting unstart then any other method.
CORPUS LUTEUM—CONCEPTUS—FOLLICLE RELATIONSHIPS DURING THE FERTILE CYCLE IN RHESUS MONKEYS: PREGNANCY MAINTENANCE DESPITE EARLY LUTEAL REMOVAL (1979)

To determine how early in pregnancy cyclic follicle growth is interrupted, 6 pregnant monkeys were luteectomized (CLX) on day 29 or 30 of the cycle (approximately 1 week after implantation) to abbreviate the fertile cycle to approximately the length of nonfertile cycles. Unexpectedly, 3 of 6 monkeys remained pregnant despite early removal of luteal support. In the remainder, which aborted, the next ovulation was delayed beyond the interval typically observed after CLX in nonfertile cycles. Two of 4 other monkeys ovariectomized on day 29 also maintained their pregnancies. Our findings demonstrate that: 1) in 5 of 10 monkeys, the conceptus could survive without luteal support within a week after luteal rescue, and 2) secretion(s) of the conceptus also contribute to an arrest of cyclic follicle growth early in pregnancy.
Synthetic Origin-Dependent catalytic activity of Metal-Organic Frameworks: Unprecedented demonstration with ZIF-8 s on CO2 cycloaddition reaction (2022)

In this study, the catalytic activities of three types of zeolitic imidazolate framework-8 (ZIF-8) (two types were synthesized in aqueous and methanolic media, while the other was commercially available) with respect to CO2 cycloaddition to epichlorohydrin were evaluated. Surprisingly, only the ZIF-8 that was synthesized in an aqueous medium showed a marked catalytic performance, leading to the generation of the desired product, chloropropene carbonate. On the contrary, the other two types of ZIF-8 showed little to no catalytic activity. It is conjectured that the water molecules occluded inside the as-synthesized ZIF-8 triggered the dissociation of Zn-N bonds, resulting in a concomitant transformation to a new, dense phase. Accordingly, it is plausible that dissociated Zn or N species were formed during the reaction. In particular, we found that the dissociated N species arising from the dissociation of Zn-N bonds were pyrrolic and pyridinic, while the dissociated Zn species were bound to hydroxyl groups. Finally, complementary interpretation of CO2– and NH3-based temperature-programmed desorption and NH3-adsorbed Fourier transform infrared spectroscopy results revealed that the dissociated Zn species connected with hydroxyl groups, observed only in the ZIF-8 synthesized in an aqueous medium, served simultaneously as Lewis acids and bases and, thus, were crucial to the CO2 cycloaddition reaction.
Abstract A190: In vivo activity of SGI-110, a novel hypomethylating agent for treatment in hematology and solid malignancies (2009)

Abstract SGI-110 is a second generation hypomethylating agent being developed for treatment in myelodysplastic syndrome (MDS) and solid tumor malignancies. In previous work, SGI-110 has demonstrated potent in vivo activity in a number of tumor types, including non-hematological cell lines. Current efforts are underway to optimize formulation and delivery of SGI-110 for first-in-human (FIH) studies. In animals, SGI-110 is well-tolerated across multiple species utilizing multiple routes of drug delivery. Tolerability studies have been performed in mouse, rat, and rabbit models with multiple dose routes and schedules. Myelosuppression is an observed toxicity endpoint for hypomethylating agents. Hence, myelotoxic effects were investigated by comparing RBCs and bone marrow cellularity of mice treated with and without SGI-110. Mice dosed with SGI-110 for five consecutive days showed a significant decrease in RBCs at the end of the dosing period and a continued decrease one week after dosing. Bone marrow cellularity also showed a decrease at the end of dosing, but recovered to near normal levels one week later. Interestingly, RBCs from SGI-110 treated mice were elevated in the bone marrow after the dosing period. Pyrosequencing methylation analysis of colon samples was also evaluated in this study. A significant decrease in B1 methylation was observed in colon samples of treated mice, indicating global DNA methylation is being inhibited. Decreased levels in several hematology parameters and decreases in bone marrow cellularity were also observed in rat and rabbit studies after five consecutive days of SGI-110 dosing. Increased dosing frequency, while maintaining the same total dose per week, appears to result in increased toxicity. Previous pharmacokinetic studies have shown that SGI-110 rapidly metabolizes to decitabine, an FDA-approved drug for MDS. Multiple formulations and different routes of delivery were examined to determine the optimal dose form to be used in FIH studies. Subcutaneous dosing results in bioavailability that is similar to that of intravenous dosing. Subcutaneous dosing appears to reduce the Cmax while maintaining similar AUC values when compared to intravenous dosing. Similar results in pharmacokinetic parameters are observed when the delivery vehicle is changed from an aqueous to non-aqueous formulation. SGI-110 is a novel hypomethylating agent that is well-tolerated in rodent models, provides excellent PK exposure, and demonstrates inhibition of DNA methylation in a mouse model. Citation Information: Mol Cancer Ther 2009;8(12 Suppl):A190.
Src inhibition through a phase II study of 5-fluorouracil, oxaliplatin, plus dasatinib (FOLFOX-D) in first-line metastatic pancreatic adenocarcinoma. (2014)

319 Background: Triplet drug therapy is now a standard for metastatic pancreatic cancer (mPCa) but limited in use due to toxicity. Src is constitutively active in mPCa and associated with increased chemoresistance. Src inhibition increases oxaliplatin (ox) activity. Inhibition of Src reduces tumor expression of thymidylate synthase with subsequent 5FU chemoresistance reversal. Dasatinib (D) is an oral multi-tyrosine kinase inhibitor (TKI) capable of inhibiting Src. Demonstrating activity of this triplet combination therapy in mPCa represents a scientifically rational approach to a clinical unmet need. Methods: Eligible pts have biopsy proven, RECIST measurable disease with no prior therapy for met disease and at least 6 months since completing adjuvant therapy, ECOG PS 0-2 and adequate organ function. Pts received standard doses of mFOLFOX6 chemotherapy (5-FU/LV 400mg/m 2 bolus and Ox 85 mg/m 2 D1; 5-FU 2,400 mg/m 2 CIVI x 46h D1-2) with continuous D (150 mg PO daily) repeated q14d with tumor assessments q8w. The primary endpoint is progression-free survival (PFS) with secondary endpoints of objective and biochemical response rates, freedom from mets, overall survival (OS), toxicity, and quality of life. Sample size was based on a 50% improved median PFS from 4 (historical) to 6 months (m). Results: 14 of 42 planned pts have received therapy and are included in this report. Baseline pt demographics are in the table. 10 pts (71%) had a grade 3 AE and 1 (7%; sepsis) had a grade 4 AE. There were no grade 5 toxicities. Most common grade 3 AEs included anemia (29%), hyponatremia (29%), neutropenia (21%) and fatigue (21%). Conclusions: Enrollment continues with ongoing toxicity and efficacy monitoring of this targeted combination. Exploratory tissue and serum correlative analyses to identify predictors of response are planned. Clinical trial information: NCT01652976. [Table: see text]
In Vivo Imaging of Lipid Droplets and Oxygen Status in Hepatic Tissues of Nonalcoholic Fatty Liver Model Mice Using a Lipophilic Ir(III) Complex (2023)

Nonalcoholic fatty liver disease (NAFLD) is becoming common worldwide. In pathophysiological studies of NAFLD, an <i>in vivo</i> optical probe that enables visualization of lipid droplets (LDs) and imaging of oxygen status in hepatic tissues simultaneously would be very useful. Here, we present the phosphorescent Ir(III) complex BTP ((btp)<sub>2</sub>Ir(acac) (btp = benzothienylpyridine, acac = acetylacetone)) as the first probe that meets this requirement. BTP was efficiently taken up into cultured 3T3-L1 adipocytes and selectively accumulated into LDs. Quantifying oxygen levels in LDs based on the phosphorescence lifetime of BTP allowed us to track changes in cellular oxygen tension after treatment with metabolic stimulants. Phosphorescence lifetime imaging microscopy combined with intravenously administered BTP in mice enabled specific visualization of LDs in hepatic lobules and simultaneous imaging of the oxygen gradient that decreased from the portal vein (PV) to the central vein (CV). NAFL model mice were created by feeding a high-fat diet (HFD) to mice for 3 or 7 days. The mice fed an HFD showed a marked increase in the amount and size of LDs in hepatocytes compared with those fed a normal diet, leading to abnormal microvascular structures. In addition, HFD-fed mice also exhibited reduced oxygen tension in areas other than the CV. Multicolor imaging with the LD-accumulated oxygen probe BTP and vasculature-staining FITC-lectin suggested that structural distortions of the sinusoidal microvasculature caused by enlarged LDs were associated with partial hypoxia in NAFL.
ChemInform Abstract: One‐Step Synthesis of SBA‐15 Containing Tungsten Oxide Nanoclusters: A Chemoselective Catalyst for Oxidation of Sulfides to Sulfoxides under Ambient Conditions. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Sauter mean diameter of a diesel spray injected into an environment of high pressure. (1989)

The new empirical equations to represent the Sauter mean diameter of a spray injected from a diesel nozzle were reported in this paper. In order to determine the new equations of the mean diameter, drop sizes of a diesel spray were analyzed by a laser diffraction technique. Liquids with different viscosities and different surface tensions were tested. The maximum injection pressure and the maximum ambient pressure were 90 MPa and 3 MPa, respectively. According to the tendencies of break-up length and drop sizes of a spray for an injection velocity and an ambient pressure, the spray formation mechanism could be divided into two categories as a function of the injection velocity and physical properties of the liquid. Finally, dimensionless analysis for each category of a spray could lead tot the empirical equations of the Sauter mean diameter.
Design and Field Deployment of a Torsional Vibration Damper (2022)

Abstract Different vibration phenomena and vibration dysfunctions are excited by the drilling process. The associated dynamic loads result in downhole tool failures and inefficient drilling if not properly managed. Vibration mitigation strategies based on adjustment of operational parameters often compromise the rate of penetration (ROP). The purpose of downhole tools for vibration mitigation is to enlarge the envelope of drilling parameters with low levels of vibrations. The associated more aggressive drilling parameters enable a higher ROP. A torsional vibration damper that is designed to mitigate high-frequency torsional oscillations (HFTO) is introduced in this work along with the results of first field deployments. A damping-threshold needs to be exceeded by a damper to mitigate self-excited HFTO. The damping threshold is defined through the energy input resulting from the bit-rock interaction and depends on the instantaneous operational parameters. The design space to provide damping, however, is limited. Thus design and dimensioning of the torsional vibration damper is optimized based on theoretical insights, downhole vibration data analysis, modeling and simulations, and laboratory testing at different scale. This process is presented in the paper. The placement of the damper elements within the drilling system has been identified as a critical task to effectively dampen the critical modes related to HFTO. The simulated results for the BHA that is deployed in the field are presented. In a case study the first field deployments of the torsional vibration damper are discussed. The results of the damper deployments and a comparison to offset well data prove that the damper effectively mitigates HFTO. Snapshots of high-speed vibration data sampled with 1000 Hz are analyzed and related to the modeling results. The suppression of HFTO enabled the application of more aggressive operational parameters and led to an increase in the ROP compared to benchmark runs. First trends prove a high reliability of the BHA with torsional vibration damper tool. The torsional vibration damper has been successfully introduced in the field and has proven to effectively suppress HFTO. A holistic methodology has been developed that allows for an application specific optimization of the damper deployment. The torsional vibration damper enables a higher rate of penetration at low levels of vibrations and an increased reliability of the tools deployed and, ultimately, decreases the well delivery cost significantly.
ChemInform Abstract: The Design and Development of 2‐Aryl‐2‐hydroxy Ethylamine Substituted 1H,7H‐Pyrido[1,2,3‐de]quinoxaline‐6‐carboxamides as Inhibitors of Human Cytomegalovirus Polymerase. (2010)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Solutions of the benchmark problems by the dispersion-relation-preserving scheme (1995)

Puripotent human H7 and mouse F9 embryonal cells express the genes for most of the Wnts and Frizzleds. In contrast, multipotent human mesenchymal cells are deficient in expression of Frizzled-8 and of 6 Wnt genes.
Heterogeneity of Phagocytosis for Inhaled versus Instilled Material (1992)

Animal experiments involving lung exposure to particles and toxins often use intratracheal instillation, although inhalation is more physiologically relevant to human respiratory tract exposures. Using nontoxic magnetic particles, we examined the particle content distribution within the macrophage population lavaged from the lungs of Syrian golden hamsters exposed either by inhalation or by intratracheal instillation. One to 3 days after iron oxide particle delivery to the lungs, lung macrophages were harvested from animals in pairs, one exposed by inhalation and one exposed by instillation. The macrophages were then magnetically fractionated according to magnetic iron oxide content by flowing the cell suspension through tubing placed within the magnetic field gradient of an electromagnet. Macrophages that had ingested the largest quantity of magnetic iron oxide preferentially collected adjacent to the tubing wall when the electromagnet was at its lowest current; those with fewer particulates collected at correspondingly higher amperages; those cells that were never pulled out of the flowing stream had little or no magnetic iron oxide content. Our results showed that 80% of the lavaged cell population from animals exposed by inhalation had measurable particle content, whereas by instillation, many cells (70%) received no dose at all. Exposure by inhalation produced a more even distribution of dose among lung macrophages. Macrophage intracellular motions showed a decrease when cell content exceeded 7 to 8% of cell volume. We conclude that the method of particle delivery to lungs can influence the dose distribution among lung macrophages.
Performance comparison between electromechanical and electro-hydrostatic regenerative shock absorbers (2022)

Abstract Controllable damping solutions are increasingly finding their way into passenger cars and other vehicles. They improve ride quality by enhancing comfort and handling performance. Semi-active solutions based on controlled valves or variable-rheology fluids are by far the most common technologies in the automotive industry. However, regenerative alternatives that employ electric machines can be seen as a desirable evolution of the suspension market. In this context, the present paper studies two regenerative solutions: electro-hydrostatic and rotary electromechanical dampers. Transmission interfaces are particularly relevant in these technologies. Adequate choices are needed to guarantee proper packaging, performance, structural integrity, and high efficiency. This work compares both technologies in terms of design and packaging. Furthermore, experimental results are analysed to understand the performance of damping solutions. It is demonstrated that the rotary electromechanical device outperforms its electro-hydrostatic counterpart in important features, such as conversion efficiency, envelope, mass and dynamic behaviour.
Automated extraction of mutation data from the literature: application of MuteXt to G protein-coupled receptors and nuclear hormone receptors (2004)

We present a computational method that identifies and extracts mutation data from the scientific literature. We focused on the extraction of single point mutations for the GPCR and NR superfamilies. After validation by plausibility filters, the mutation data is integrated into the corresponding MCSIS where it is combined with structural and sequence information already stored in these databases. We extracted and validated 2736 true point mutations from 914 articles on GPCRs and 785 true point mutations from 1094 articles on NRs. The current version of our automated extraction algorithm identifies 49.3% of the GPCR point mutations with a specificity of 87.9%, and 64.5% of the NR point mutations with a specificity of 85.8%. MuteXt routinely analyzes 100 electronic articles in approximately 1 h.
Interactive analysis of big data (2012)

New user interfaces can transform how we work with big data, and raise exciting research problems that span human-computer interaction, machine learning, and distributed systems.