gebhart/patrepeval huggingface dataset:
[Expression and its clinical significance of p27 protein in cervical carcinoma tissues]. (2004)

The expression of p27 protein is related to differentiation degree of cancer cells, clinical phase of the patients and lymph node metastasis. Detection of p27 protein expression may be valuable to assess prognosis of the patients with cervical carcinoma.
Differences in the expression profiles of CD45RB, Pgp-1, and 3G11 membrane antigens and in the patterns of lymphokine secretion by splenic CD4+ T cells from young and aged mice. (1990)

Previous studies indicate that the 3G11, CD45RB, and Pgp-1 determinants are differentially expressed on CD4+ T cell subsets in the mouse. We used multicolor immunofluorescence staining and flow cytofluorometric analysis to examine the expression of each of these determinants on splenic CD4+ cells from young (age 3 to 6 mo) and aged (age 24 to 26 mo) C57BL/6 mice. The CD4+ pool from aged mice contained significantly reduced numbers of 3G11+ and CD45RBhi cells, but increased numbers of Pgp-1hi cells, in comparison with the young group. Analysis of the simultaneous expression of all three subset determinants on CD4+ cells revealed that, in young mice, the major fraction (greater than 50%) was 3G11+CD45RBhiPgp-1lo. Among the less prevalent cell phenotypes, reductions in 3G11 expression correlated with decreases in CD45RB levels and increases in Pgp-1 levels. The phenotype that dominated the young group (3G11+CD45RBhiPgp-1lo) was approximately fivefold less represented in the aged group. The CD4+ pool from aged mice was characterized by increases in the 3G11-CD45RBvariablePgp-1hi and the 3G11+CD45RBloPgp-1hi phenotypes. To evaluate possible age-associated differences in cytokine secretion patterns by splenic CD4+ cells, purified CD4+ cells from each age group were stimulated in vitro with immobilized anti-CD3 epsilon mAb and accessory cells. At various times thereafter, supernatants from cultures were tested for IL-2 and IL-4 content by using the CTLL.6 and 11.6 bioassays, respectively, and the CD4+ cells were assayed for [3H]TdR uptake. Cell cultures from the aged group exhibited similar peak IL-2 accumulation and lower peak [3H]TdR uptake, but greatly increased peak IL-4 accumulation, as compared with cell cultures from the young group. The expression patterns of subset determinants, in conjunction with cytokine secretion profiles, indicate that, in aged mice, marked alterations occur in the subset composition of the splenic CD4+ cell pool. These findings are discussed in the context of previous findings on changes in T cell reactivity with advancing donor age.
Autophagy maintains stem cells and intestinal homeostasis in Drosophila (2018)

Intestinal homeostasis is maintained by tightly controlled proliferation and differentiation of tissue-resident multipotent stem cells during aging and regeneration, which ensures organismal adaptation. Here we show that autophagy is required in Drosophila intestinal stem cells to sustain proliferation, and preserves the stem cell pool. Autophagy-deficient stem cells show elevated DNA damage and cell cycle arrest during aging, and are frequently eliminated via JNK-mediated apoptosis. Interestingly, loss of Chk2, a DNA damage-activated kinase that arrests the cell cycle and promotes DNA repair and apoptosis, leads to uncontrolled proliferation of intestinal stem cells regardless of their autophagy status. Chk2 accumulates in the nuclei of autophagy-deficient stem cells, raising the possibility that its activation may contribute to the effects of autophagy inhibition in intestinal stem cells. Our study reveals the crucial role of autophagy in preserving proper stem cell function for the continuous renewal of the intestinal epithelium in Drosophila.
Ranking residential properties by a multicriteria single price model (2010)

This study describes an application of the multicriteria single price model (Ballestero) to the ranking of alternatives. By a generalization of the original model, the equilibrium set of alternatives can be characterized from the viewpoints, respectively, of the demander and the supplier, and from that the efficiency index can be calculated. We demonstrate how, in a state of equilibrium, the two viewpoints result inevitably in inverse orders of ranking. In contrast with other proposals for full ranking of alternatives, the method used in the present study (i) assumes a moderate attitude on the part of the decision maker towards risk, with a robust axiomatic basis; (ii) assigns weights to the criteria independently of which alternative is being evaluated and the attitude (optimistic or pessimistic) of the decision maker; (iii) produces a cardinal hierarchy of the alternatives and not just an ordinal one. The model is illustrated by a sample of residential properties in the city of Valencia, Spain.
Development of a Simple and Highly Sensitive Enzyme Immunoassay for Hepatitis C Virus Core Antigen (1999)

A highly sensitive enzyme immunoassay (EIA) for the hepatitis C virus (HCV) core antigen (HCVcAg) was developed, and its performance was compared with that of the AMPLICOR HCV test (Roche Molecular Systems). The developed one-step pretreatment method, 30-min incubation of the specimen with a solution containing three different types of detergents (Triton X-100, 3-[(3-cholamidopropyl)-dimethylammonio]-1-propanesulfonate [CHAPS], and sodium dodecyl sulfate), does not require any special device. Because the interfering anti-core antibody in the sample was sufficiently inactivated by the pretreatment, HCVcAg in the sample could be detected. The immunoreactivity on gel filtration was shifted from void fractions to those corresponding to the molecular mass range from 20 to 25 kDa, which is equal to the estimated molecular mass of HCVcAg, after the pretreatment. By the recovery test with HCVcAg-positive serum, the recovery rate was 93.5 to 106. 5%. There was no interference with the EIA by anticoagulants or blood components in the serum. When the cutoff value was tentatively set at 0.5 mU/ml based on the distribution of healthy subjects' sera, the sera of all healthy subjects (n = 125) and patients with hepatitis B (n = 50) were negative. HCVcAg was detected in sera from 57 of 73 individuals (78.1%) with anti-HCV antibody. Similarly, HCV RNA was detected in sera from 59 individuals (80.8%) with the AMPLICOR HCV as the qualitative test (AMPLICOR HCV test) and in sera from 54 individuals (74.0%) by the AMPLICOR HCV Monitor as the quantitative test (AMPLICOR Monitor test). Concentrations of HCVcAg and HCV RNA (measured by the AMPLICOR Monitor test) correlated significantly (r = 0.8, P < 0.001). On seroconversion panels, HCVcAg was detected during the early stage of infection, when anti-HCV antibodies had not been produced. This assay for HCVcAg is simpler than assays for HCV RNA based on gene technology and shows specificity and sensitivity equivalent to those of the AMPLICOR HCV test.
Register renaming and dynamic speculation: an alternative approach (1993)

Presents a novel microparallel taxonomy for machines with multiple-instruction processing capabilities including VLIW, superscalar, and decoupled machines. The taxonomy is based upon the static or dynamic behavior of four abstract, operational stages that an instruction passes through. These stages are fetch, decode, execute, and retire. This two valued, four variable taxonomy results in sixteen ways that a processor's microarchitecture can be specified. The paper categorizes different machine instances that are either actual implementations or proposed systems within the taxonomy framework. Four new processor microarchitectures are postulated which provide additional features and are instances of the remaining unexplored microparallel classifications.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Volumetric evaluation of orbital fractures treated by titanium mesh (2022)

Abstract Purpose: Orbital fractures are high prevalent and result in volumetric changes which may result in clinical impairment as enophthalmos and diplopia. This study aims to evaluate orbital volume and anteroposterior eyeball position in orbital fractures treated by titanium mesh. Methods: This multicenter study evaluated 60 postoperative CT scans of unilateral orbital fractures treated using titanium mesh. Orbital defects were classified according to the extension and involved regions, and the orbital volumes were analyzed by two methods, image sectioning (IS) and computerized segmentation (CS). The eyeball position was obtained from the axial slice in the mid orbit region. Differences up to 8.0% (volume) and 2.0 mm (eyeball position) were considered normal. Results: Most of defects were class II (n=25) and class III (n=26). Volumetric differences between unaffected and reconstructed orbit ranged from -7.15% to 10.46% (mean: -0.15%), and from -6.32% to 9.69% (mean: -0.01%) in IS and CS method, respectively. In both methods, two reconstructions were greater than anatomical differences, however there was no statistical differences between the orbits in both methods, IS (p=0.852) and CS (p=0.987). Anteroposterior eyeball position ranged from -0.9 mm to 1.8 mm. The correlation between defect classification, eyeball position and IS or CS, were not positive. Conclusion: In conclusion, regardless of the extent of the orbital defect or evaluation method, fractures treated by titanium mesh reestablished adequately the orbital volume.
Multiscale decompositions of Hardy spaces (2021)

An inspiration at the origin of wavelet analysis (when Grossmann, Morlet, Meyer and collaborators were interacting and exploring versions of multiscale representations) was provided by the analysis of holomorphic signals, for which the images of the phase of Cauchy wavelets were remarkable in their ability to reveal intricate singularities or dynamic structures, such as instantaneous frequency jumps in musical recordings. Our goal is to follow their seminal work and introduce recent developments in nonlinear analysis. In particular we sketch methods extending conventional Fourier analysis, exploiting both phase and amplitudes of holomorphic functions. The Blaschke factors are a key ingredient, in building analytic tools, starting with the Malmquist Takenaka orthonormal bases of the Hardy space, continuing with "best" adapted bases obtained through phase unwinding, and concluding with relations to composition of Blaschke products and their dynamics. We also remark that the phase of a Blaschke product is a one layer neural net with arctan as an activation sigmoid and that the composition is a "Deep Neural Net" whose depth is the number of compositions. Our results provide a wealth of related library of orthonormal bases.
A hybrid cooperative design for energy-efficient surveillance in Wireless Multimedia Sensor Networks (2012)

In Wireless Multimedia Sensor Networks (WMSNs) the lifetime of battery-operated visual nodes is limited by their energy consumption, which is proportional to the energy required for sensing, processing, and transmitting the data. Given the large amount of data generated by the visual nodes,\nboth processing and transmitting image data are quite costly in terms of energy in comparison with other types of sensor networks. Therefore, energy efficiency is a main concern in WMSNs. In this paper an energy efficient collaborative mechanism for environment surveillance is proposed. The\nproposed scheme employs a mixed random deployment of acoustic and visual sensor nodes. Acoustic sensors detect and localize the occurred event/object(s) in a duty-cycled manner by sampling the received signals and then trigger the visual sensor\nnodes covering the objects to monitor them. Hence, visual sensors are warily scheduled to be awakened just for monitoring the object(s) detected in their domain, otherwise they save their energy.
Isolation and characterization of an acute promyelocytic leukemia cell line selectively resistant to the novel antileukemic and apoptogenic retinoid 6-[3-adamantyl-4-hydroxyphenyl]-2-naphthalene carboxylic acid (2000)

6-[3-adamantyl-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) is a novel compound that represents the prototype of a new class of synthetic retinoids with apoptogenic properties in acute promyelocytic leukemia (APL) and other types of leukemia. In this article, using SCID mice xenografted with APL-derived NB4 cells, we demonstrate that CD437 has significant antileukemic activity in vivo. In addition, we report on the isolation and characterization of an APL cell line (NB4.437r) resistant to CD437. The cell line retains expression of PML-RAR and is approximately 33-fold more resistant than the parental counterpart to the apoptogenic effects of the retinoid. Resistance is relatively specific to CD437 and structural congeners because the NB4.437r cell line is still sensitive to various types of apoptogenic compounds. The CD437-resistant cell line maintains sensitivity to the antiproliferative and apoptotic action of all-trans-retinoic acid, AM580, and fenretinide, though it shows partial resistance to the cytodifferentiating effects of the first 2 compounds. Resistance to CD437 lays upstream of the CD437-induced release of cytochrome c from the mitochondria and the activation of caspase-3, -7, -8, and -9. Furthermore, NB4.437r cells are deficient in the CD437-dependent activation of nuclear NFkb and AP1-binding activities and in the phosphorylation of the protein kinase Akt. In the case of AP1, deficient assembly of the complex is not caused by the lack of activation of the Jun N-terminal kinase (JNK) family of kinases. The novel cell line will be useful in the elucidation of the molecular mechanisms underlying the apoptogenic action of CD437 and structurally related retinoids.
Synthesis of 3-acylfurans from 1,3-dicarbonyl compounds and aliphatic nitro-olefins (1978)

Some 1,3-dicarbonyl compounds (acetylacetone, cyclohexane-1,3-dione, 5,5-dimethylcyclohexane-1,3-dione, and ethyl acetoacetate) and aliphatic nitro-olefins (2-nitropropene, 2-nitrobut-1-ene, and 2-nitrobut-2-ene) directly gave 3-acylfurans (8)–(15) in a KF-catalysed reaction.
Dual Induction of Mitochondrial Apoptosis and Senescence in Chronic Myelogenous Leukemia by Myrtucommulone A (2015)

Despite recent advances in the treatment of chronic myelogenous leukemia (CML), the development of drug resistance and minimal residual disease remain major challenges for the treatment of CML patients, thus highlighting the need to develop innovative new approaches to improve therapeutic outcome. Myrtucommulone A (MCA) is a nonprenylated acylphloroglucinol isolated from the leaves of myrtle, a plant traditionally used in folk medicine. To date, studies addressing bioactivities of myrtle and its specific components are rare. Here, we investigated the biological effects of MCA, focusing on its anti-leukemic activity. As evidenced by fragmented nuclei after Hoechst/propidium iodide staining and poly (ADP-ribose) polymerase cleavage, MCA induces apoptosis in CML cells through down-regulation of anti-apoptotic proteins. Interestingly, we showed that chronic treatment with MCA at low doses induced senescence in CML cells. Taken together, this study highlights the chemotherapeutical potential of this natural product in human leukemia.
Hardware Memory Management for Future Mobile Hybrid Memory Systems (2020)

The current mobile applications have rapidly growing memory footprints, posing a great challenge for memory system design. Insufficient DRAM main memory will incur frequent data swaps between memory and storage, a process that hurts performance, consumes energy, and deteriorates the write endurance of typical flash storage devices. Alternately, a larger DRAM has higher leakage power and drains the battery faster. Furthermore, DRAM scaling trends make further growth of DRAM in the mobile space prohibitive due to cost. Emerging nonvolatile memory (NVM) has the potential to alleviate these issues due to its higher capacity per cost than DRAM and minimal static power. Recently, a wide spectrum of NVM technologies, including phase-change memories (PCMs), memristor, and 3-D XPoint has emerged. Despite the mentioned advantages, NVM has longer access latency compared to DRAM and NVM writes can incur higher latencies and wear costs. Therefore, the integration of these new memory technologies in the memory hierarchy requires a fundamental rearchitecting of traditional system designs. In this work, we propose a hardware-accelerated memory manager (HMMU) that addresses in a flat address space, with a small partition of the DRAM reserved for subpage block-level management. We design a set of data placement and data migration policies within this memory manager such that we may exploit the advantages of each memory technology. By augmenting the system with this HMMU, we reduce the overall memory latency while also reducing writes to the NVM. The experimental results show that our design achieves a 39% reduction in energy consumption with only a 12% performance degradation versus an all-DRAM baseline that is likely untenable in the future.
Slepian-Wolf Coding for Reconciliation of Physical Layer Secret Keys (2010)

In this paper, we show how to compute the Slepian-Wolf lower bound for the reconciliation of physical layer secret keys between two radio terminals. Two coding approaches, including the syndrome method and the parity method, have been proven to require the same number of bits exchanged between two terminals for the reconciliation in the noiseless environment. We also present a practical coding approach based on LDPC codes, and the gap between the practical approach and the Slepian-Wolf bound is given.
Evidence-based management of glaucoma. (2005)

The evidence-based medicine (EBM) is a new medical mode that is completely different from traditional experience-based medicine. The core of EBM is that decision-making during clinical practices must be based on objective research results. With the rapid development of modern ophthalmology, some former viewpoints according to experience-based medicine face challenges. Evidence-based ophthalmology (EBO) is imperative under the situation. Glaucoma, as a disease resulting in blindness, which can not be cured by operation, is thought more and more of by medical management officials and doctors. One challenge for ophthalmologists entering the 21st century will be to make clinical decisions based on valid information or evidence rather than intuition, hearsay, or peer practice. How can we do? Here reviews the application of EBM in medical management of glaucoma since EBM' s naissance and give a reference.
Upregulated expression of Ezrin and invasive phenotype in malignantly transformed esophageal epithelial cells (2003)

The upregulated ezrin expression is one of the important factors that are possibly associated with the invasive phenotype formation in malignantly transformed esophageal epithelial cells.
DEVELOPMENT OF A MACHINE VISION SYSTEM FOR WEED DETECTION DURING BOTH OF OFF-SEASON AND IN-SEASON IN BROADACRE NO-TILLAGE CROPPING LANDS (2014)

More than half of the Australian cropping land is no-tillage and weed control within continuous no-tillage agricultural cropping area is becoming more and more difficult. A major problem is that the heavy herbicide usage causes some of more prolific weeds becoming more resistant to the regular herbicides and therefore more powerful and more expensive options are being pursued. To overcome such problems with aiming at the reduction of herbicide usage, this proposed research focuses on developing a machine vision system which can detect and mapping weeds or do spot spray. The weed detection methods described in this study include three aspects which are image acquisition, a new green plant detection algorithm using hybrid spectral indices and a new inter-row weed detection method taking the advantage of the location of the crop rows. The developed method could detect the weeds both during the non-growing summer period and also within the growing season until the canopy of the crop has closed. The design of the methods focuses on overcoming the challenges of the complex no-tillage background, the faster image acquisition speed and quicker processing time for real-time spot spray. The experiment results show that the proposed method are more suitable for the weed detection in the notillage background than the existing methods and could be used as a powerful tool for the weed control.
Editorial Comment (1987)

No AccessJournal of Urology1 May 1987Editorial Commentis accompanied byPenile Cancer: Relation of Extent of Nodal Metastasis to Survival W. Scott McDougal W. Scott McDougalW. Scott McDougal More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)44282-0AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Editorial Comment." The Journal of Urology, 137(5), pp. 881–882 © 1987 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsRelated articlesJournal of Urology12 Nov 2018Penile Cancer: Relation of Extent of Nodal Metastasis to Survival Volume 137Issue 5May 1987Page: 881-882 Advertisement Copyright & Permissions© 1987 by The American Urological Association Education and Research, Inc.MetricsAuthor Information W. Scott McDougal More articles by this author Expand All Advertisement PDF downloadLoading ...
Photosynthetic Hydrogen Production by a Hybrid Complex of Photosystem I and [NiFe]-Hydrogenase (2009)

Nature provides key components for generating fuels from renewable resources in the form of enzymatic nanomachines which catalyze crucial steps in biological energy conversion, for example, the photosynthetic apparatus, which transforms solar power into chemical energy, and hydrogenases, capable of generating molecular hydrogen. As sunlight is usually used to synthesize carbohydrates, direct generation of hydrogen from light represents an exception in nature. On the molecular level, the crucial step for conversion of solar energy into H(2) lies in the efficient electronic coupling of photosystem I and hydrogenase. Here we show the stepwise assembly of a hybrid complex consisting of photosystem I and hydrogenase on a solid gold surface. This device gave rise to light-induced H(2) evolution. Hydrogen production is possible at far higher potential and thus lower energy compared to those of previously described (bio)nanoelectronic devices that did not employ the photosynthesis apparatus. The successful demonstration of efficient solar-to-hydrogen conversion may serve as a blueprint for the establishment of this system in a living organism with the paramount advantage of self-replication.
Discussion: Two-Center Review of Posterior Vault Expansion following a Staged or Expectant Treatment of Crouzon and Apert Craniosynostosis (2023)

Dallas, TX From The Craniofacial Center. Received for publication March 1, 2022; accepted May 20, 2022. Disclosure:The author has no financial interest to declare in relation to the content of this Discussion or of the associated article. No funding was received for this work. Jeffrey A. Fearon, MD, The Craniofacial Center, 7777 Forest Lane, Suite C-700, Dallas, TX 75220, [email protected], Twitter: @jeffrey_fearon