gebhart/patrepeval huggingface dataset:
Treatment of Severe Inflammatory Eye Disease in Patients of Reproductive Age and during Pregnancy (2012)

Inflammatory eye diseases (IED) such as uveitis affect females and males in the prime of their reproductive life. Despite their propensity to lead to significant visual loss, there have been very few studies of the management of patients with IED who are pregnant or plan a pregnancy during the course of therapy. The first trimester and postpartum period may be associated with an exacerbation of IED and it is important to have available medications that control the disease and do not cause miscarriage or fetal abnormalities. Several immunosuppressive drugs are contraindicated in pregnancy (methotrexate and alkylating agents), while others (corticosteroids, azathioprine, and cyclosporin) may be considered for use in pregnancy. Most drugs are excluded from use in pregnancy not because of proven teratogenicity but because of the lack of available evidence of their safety for the fetus.
Supplementary Figures 1-5 from GR and ER Coactivation Alters the Expression of Differentiation Genes and Associates with Improved ER<sup>+</sup> Breast Cancer Outcome (2023)

&lt;p&gt;Supplementary Figure 1. ChIP-seq for GR and ER peaks and associated genes and motifs. Supplementary Figure 2. GR immunoprecipitation demonstrates ER interaction. Supplementary Figure 3. Most represented transcription factor response element motifs in Dex/E2-treated EBR and GBR peaks in regulatory regions of KDM4B, IGFBP4, and VDR. Supplementary Figure 4. Knockdown efficiency at 24h and 48h as measured by Q-RT-PCR, normalized to control siRNA pool. Supplementary Figure 5. Flow chart of GR ChIP-seq data analysis and integration of genome-wide gene expression (microarray) data.&lt;/p&gt;
Outcomes of laparoscopic gastrectomy after endoscopic treatment for gastric cancer: a comparison with open gastrectomy. (2013)

Purpose: Additional gastrectomy is needed after endoscopic resection for early gastric cancer when pathology confirms any possibility of lymph node metastasis or margin involvement. No studies depicted the optimal type of surgery to apply in these patients. We compared the short-term and long-term outcomes of laparoscopic gastrectomy with those of open gastrectomy after endoscopic resection to identify the optimal type of surgery. Materials and Methods: From 2003 to 2010, 110 consecutive patients who underwent gastrectomy with lymphadenectomy either by laparoscopic (n=74) or by open (n=36) for gastric cancer after endoscopic resection were retrospectively analyzed. Postoperative and oncological outcomes were compared according to types of surgical approach. Results: Clinicopathological characteristics were comparable between the two groups. Laparoscopic group showed significantly shorter time to gas passing and soft diet and hospital day than open group while operation time and rate of postoperative complications were comparable between the two groups. All specimens had negative margins regardless of types of approach. Mean number of retrieved lymph nodes did not differ significantly between the two groups. During the median follow-up of 47 months, there were no statistical differences in recurrence rate (1.4% for laparoscopic and 5.6% for open, P=0.25) and in overall (P=0.22) and disease-free survival (P=0.19) between the two groups. Type of approach was not an independent risk factor for recurrence and survival. Conclusions: Laparoscopic gastrectomy after endoscopic resection showed comparable oncologic outcomes to open approach while maintaining benefits of minimally invasive surgery. Thus, laparoscopic gastrectomy can be a treatment of choice for patients previously treated by endoscopic resection.
Behaviour of multi layered geocell reinforced bed subjected to repeated load (2016)

This paper describes a series of the plate load tests performed in a test pit measuring 20002000 mm in plane and 700 mm in depth. To simulate traffic loadings, fifteen loading and unloading cycles were applied to the loading plate with amplitudes of 400 and 800 kPa. The optimum depth of the top most layer of geocell and the optimum vertical spacing of geocell layers, based on plate settlement, are both approximately 0.2 times loading plate diameter. The results show that installation of the geocell layers in the foundation bed decreases the accumulated plastic and total settlements of loading plate, in addition to increase its elastic settlement. Efficiency of geocell reinforcement was decreased by increasing the number of the geocell layers for all applied stress levels and number of cycles of applied loading. The results of the testing reveal the ability of the multiple layers of geocell reinforcement to 'shakedown' to a fully resilient behavior after a period of plastic settlement except when there is little or no reinforcement and the applied cyclic pressure are large. When shakedown response is observed, then both the accumulated plastic settlement prior to a steady-state response being obtained and the resilient settlements thereafter are reduced. The results depicted that the use of four layers of geocell respectively decreases the total and residual plastic settlements about 53% and 63% and increases the resilient settlement of 145% compared with the unreinforced case.
InAs film grown on Si(111) by metal organic vapor phase epitaxy (2008)

We report the successful growth of high quality InAs films directly on Si(111) by Metal Organic Vapor Phase Epitaxy. A nearly mirror-like and uniform InAs film is obtained at 580°C for a thickness of 2 μm. We measured a high value of the electron mobili
Wädenswiler Weintage 2019 (2019)

Nach dem rekordwarmen Jahr 2018 war es nur logisch, dass der Vormittag des Rebbautags den Klimawandel zum Thema hatte. Am Nachmittag wurden die wichtigsten Label für nachhaltige Produktion präsentiert. Der Weinbereitungstag war der Vinifikation und Vermarktung der "neuen Rebsorten" gewidmet.
Analogue LSI RF switch and beamforming matrixes for communications satellites (1997)

Communications satellites use steerable antenna arrays for their communication links. These arrays need multi channel signal routing circuits up to several tens of channels. Traditionally this circuitry has been realized with hybrid technology. This has resulted to tens of Watts in power consumption and several kilograms ofpayload weight. In this paper we describe monolithic integrated switch and vector modulator matrixes for signal routing and beamforming, operating in the 160 MHz IF range. These 12 -16 I/O channel LSI level analogue circuits reduce power consumption of the satellite beamfonning circuit? to a few watts and weight to less than one kilogram. The power consumption per matrix node is 10 -20 mW compared to the 100 -500 mW consumption in the hybrid solutions.
Influence of age and sex in exhaled breath samples investigated by means of infrared laser absorption spectroscopy (2011)

Breath gas analysis provides insight into human metabolism of healthy and ill individuals. As an innovative and non-invasive method, it opens up options to improve diagnostics, monitoring and treatment decisions. Mid-infrared laser absorption spectroscopy is utilized to detect CH(4), H(2)O, CO(2), NH(3) and CH(3)OH in exhaled human breath. An off-line approach using breath sampling by means of Tedlar bags is applied. The breath gas samples are measured within the population-based epidemiological Study of Health in Pomerania (SHIP-TREND) performed at the University of Greifswald. The study covers about 5000 adult subjects aged 20-79 years within 3 years. Besides breath gas analysis many other examinations are conducted. It is expected to find associations between distinct concentration levels of species in the exhaled breath and diseases assessed in this study. The study will establish reference values for exhaled breath components and serve as background population for case-control studies. In the long run, morbidity and mortality follow-ups will be conducted, which will answer the question whether end-expiratory breath gas components predict future diseases and death. As first results, we present data from 45 dialysis patients (23 males, 22 females) which were recruited in a preliminary study in preparation for SHIP-TREND.
Hardware implementation of fast forwarding engine using standard memory and dedicated circuit (2010)

Ternary content addressable memory (TCAM) is becoming very popular for designing high-throughput forwarding engines on routers. However, TCAM has potential problems in terms of cost of hardware and cost of power, which limits it deploying large amounts of capacity. In this paper, we propose a new hardware architecture for a fast forwarding engine that fundamentally solves the potential problems of TCAM. We also develop a hardware design for our architecture. Our results show that the proposed hardware reduces the costs of hardware resources needed and power consumption into 62% and 52%, respectively.
Combined haploidentical and cord blood transplantation for refractory severe aplastic anaemia and hypoplastic myelodysplastic syndrome (2021)

Umbilical cord blood (UCB) transplantation is a potentially curative treatment for patients with refractory severe aplastic anaemia (SAA), but has historically been associated with delayed engraftment and high graft failure and mortality rates. We conducted a prospective phase 2 trial to assess outcome of an allogeneic transplant regimen that co-infused a single UCB unit with CD34<sup>+</sup> -selected cells from a haploidentical relative. Among 29 SAA patients [including 10 evolved to myelodysplastic syndrome (MDS)] who underwent the haplo cord transplantation (median age 20 years), 97% had neutrophil recovery (median 10 days), and 93% had platelet recovery (median 32 days). Early myeloid engraftment was from the haplo donor and was gradually replaced by durable engraftment from UCB in most patients. The cumulative incidences of grade II-IV acute and chronic graft-versus-host disease (GVHD) were 21% and 41%, respectively. With a median follow-up of 7·5 years, overall survival was 83% and GVHD/relapse-free survival was 69%. Patient- and transplant-related factors had no impact on engraftment and survival although transplants with haplo-versus-cord killer-cell immunoglobulin-like receptor (KIR) ligand incompatibility had delayed cord engraftment. Our study shows haplo cord transplantation is associated with excellent engraftment and long-term outcome, providing an alternative option for patients with refractory SAA and hypoplastic MDS who lack human leucocyte antigen (HLA)-matched donors.
Rapid microwave-assisted synthesis of dextran-coated iron oxide nanoparticles for magnetic resonance imaging (2012)

Currently, magnetic iron oxide nanoparticles are the only nanosized magnetic resonance imaging (MRI) contrast agents approved for clinical use, yet commercial manufacturing of these agents has been limited or discontinued. Though there is still widespread demand for these particles both for clinical use and research, they are difficult to obtain commercially, and complicated syntheses make in-house preparation unfeasible for most biological research labs or clinics. To make commercial production viable and increase accessibility of these products, it is crucial to develop simple, rapid and reproducible preparations of biocompatible iron oxide nanoparticles. Here, we report a rapid, straightforward microwave-assisted synthesis of superparamagnetic dextran-coated iron oxide nanoparticles. The nanoparticles were produced in two hydrodynamic sizes with differing core morphologies by varying the synthetic method as either a two-step or single-step process. A striking benefit of these methods is the ability to obtain swift and consistent results without the necessity for air-, pH- or temperature-sensitive techniques; therefore, reaction times and complex manufacturing processes are greatly reduced as compared to conventional synthetic methods. This is a great benefit for cost-effective translation to commercial production. The nanoparticles are found to be superparamagnetic and exhibit properties consistent for use in MRI. In addition, the dextran coating imparts the water solubility and biocompatibility necessary for in vivo utilization.
The construction of airfields during the New Georgia campaign of 1943--1944: Lessons learned by the United States Naval Construction Battalions (2008)

Prevalent depictions of United States Naval Construction Battalions (Seabees) were engendered by John Wayne in The Fighting Seabees and the musical, South Pacific. While capturing the ingenious determination that birthed their motto '˜Can Do', these incomplete pictures don't portray the complexity of construction under combat conditions in a harshly unforgiving and demanding environment. The Seabee's first combat landing was New Georgia. In six months, these battalions built five airfields, granting Allied forces air superiority over the Solomon Islands and Rabaul. Battalion records stored at the Naval Facilities Command Archives, Port Heuneme, California, combined with documents from the National Archives, provided source materials. This thesis examines the construction operations undertaken at New Georgia that were the proving grounds from which future construction methodology stemmed. This campaign tempered the men, techniques, and equipment necessary for Pacific construction. The true heart of the Seabee's was forged by the lessons learned at New Georgia.
High-molecular-weight Polymers Containing Biodegradable Disulfide Bonds: Synthesis and In Vitro Verification of Intracellular Degradation (2010)

The synthesis, physico-chemical behavior, and in vitro intracellular degradation of new biodegradable graft, diblock or multiblock polymer carriers that were designed to deliver bioactive compounds by passive tumor targeting were investigated. The graft polymer carriers consisted of the N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer backbone grafted with a semitelechelic HPMA copolymer. The diblock polymer carriers were prepared by condensation of two semitelechelic HPMA copolymers. The multiblock polymer drug carrier was prepared by oxidative polycondensation of PEG-bis-cysteine. In all three carrier systems, the single polymers were linked via biodegradable disulfide bonds forming the graft, diblock or multiblock polymers. These polymers are potential polymer carriers for solid tumor-specific drug delivery with subsequent intracellular degradation to short polymer fragments that can be excreted by glomerular filtration. Prolonged blood circulation, accumulation in solid tumors, and drug release from these carriers have been reported. Here, degradation of the polymers in model buffer solutions mimicking intracellular environment as well as after incubation with EL4 T-cell lymphoma cancer cells were investigated. In both cases, degradation resulted in polymer fragments of molecular weight below the renal threshold.
Base Selectivity Is Impaired by Mutants that Perturb Hydrogen Bonding Networks in the RB69 DNA Polymerase Active Site (2006)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionBase Selectivity Is Impaired by Mutants that Perturb Hydrogen Bonding Networks in the RB69 DNA Polymerase Active SiteGuangwei Yang, Jimin Wang, and William KonigsbergCite this: Biochemistry 2006, 45, 4, 1352Publication Date (Web):January 4, 2006Publication History Published online4 January 2006Published inissue 1 January 2006https://pubs.acs.org/doi/10.1021/bi058037phttps://doi.org/10.1021/bi058037pcorrectionACS PublicationsCopyright © 2006 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views216Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (5 KB) Get e-Alertsclose Get e-Alerts
German S3 Evidence-Based Guidelines on Focal Therapy in Localized Prostate Cancer: The First Evidence-Based Guidelines on Focal Therapy (2022)

The German S3 guidelines on PCa are the first to incorporate recommendations for FT based on evidence and expert consensus including indication criteria for FT, pretreatment, and follow-up diagnostic pathways as well as an extended overview of FT techniques and the current supportive evidence.
Verification of Web services using an enhanced UDDI server (2003)

The UDDI (Universal Description Discovery and Integration) provides classification to find the distributed Web services (WS) by keyword matching. The UDDI version 3 allows searching WS using digital signatures. However, it still needs systematic verification to ensure WS quality in a timely fashion. This paper proposes adding verification mechanism to the UDDI servers including check-in and checkout of WS. The key idea is that test scripts should be attached to WS, and both WS providers and clients use these test scripts. Before accepting a new WS into the service directory. The associated test scripts must test the new WS, and they will be accepted only if the test was successful. Before using a specific WS, a client can use the appropriate test scripts to test the WS and it will be used only if the test was successful. While the code for WS may not be available, but the associated test scripts test script specification techniques and distributed test execution techniques to perform testing with a UDDI server.
Multifibre bus for rack-to-rack interconnects based on opto-hybrid transmitter/receiver array pair (1992)

A demonstration of a system for optical rack-to-rack interconnects based on opto-hybrid array transmitter and receiver modules is reported. A six-channel interconnection at 700 Mbit/s per channel is reported and the transmitter array alone operates to 1 Gbit/s per channel. These modules are believed to be among the most complex opto-hybrids reported to date.
Medical Imaging Physics, 4th ed (2003)

Medical Imaging Physics, 4th ed Andrew D. A. MaidmentAudio Available | Share
Type Ia supernova rate at $z \sim 0.1$ (2000)

We present the EROS nearby supernova ($z \\sim 0.02 - 0.2$) search and the analysis of the first year of data (1997). A total of 80 square degrees were surveyed. Eight supernov{\\ae} were detected, four of which were spectroscopically identified as type Ia supernov{\\ae}. The search efficiency was determined with a Monte-Carlo simulation taking into account the efficiencies for both supernova detection and host galaxy identification. Assuming that for a given galaxy the supernova rate is proportional to the galactic luminosity, we compute a type Ia supernova explosion rate of: ${\\cal R} = 0.44 {}_{-0.21}^{+0.35} {}_{-0.07}^{+0.13} h^2: / 10^{10} \\lbsun / 100 {\\rm yrs}$ at an average redshift of $\\sim 0.1$ where the errors are respectively statistical and systematic (type misidentification included).
Economic Networks: The New Challenges (2009)

The current economic crisis illustrates a critical need for new and fundamental understanding of the structure and dynamics of economic networks. Economic systems are increasingly built on interdependencies, implemented through trans-national credit and investment networks, trade relations, or supply chains that have proven difficult to predict and control. We need, therefore, an approach that stresses the systemic complexity of economic networks and that can be used to revise and extend established paradigms in economic theory. This will facilitate the design of policies that reduce conflicts between individual interests and global efficiency, as well as reduce the risk of global failure by making economic networks more robust.
New protein structure‐function technology and applications (1985)

Abstract Recent advances in protein structure technology such as affinity chromatography, high performance liquid chromatography (for protein and peptide isolation) and microsequencing have provided new opportunities for answering fundamental questions as well as providing new applications. For example, it has been recognized for many years that aging causes the accumulation of “abnormal” proteins in cells. The amount of these aged proteins in human cells is exceedingly small, and only through the use of microstructural analyses has it been possible to explore the properties of aged proteins. Such studies suggest that aged cells have a decreased ability to catabolize covalently modified proteins. High‐sensitivity structural analyses also provide the opportunity to study the molecular basis of genetic diseases with small amounts of tissue or blood. Examples of the aplication of these new technologies include isolation of enzymes for therapeutic purposes such as digestion of herniated spinal discs and the debridement of burns and ulcers. The use of microencapsulated proteins and matrix‐bound enzymes also has provided new application opportunities. For example, covalently bound lactase has been found to have bio‐adhesive properties in the intestine and may be used for treatment of lactase insufficiency in persons who cannot tolerate milk or milk products.
Performance Limitations Imposed on Integrated Optical Devices by Polarization (1976)

I.O. (integrated optical) circuits will probably find their greatest use in single mode data transfer systems which utilize monomode fibers as the transmission lines. Single mode fibers will be connected to IO circuits which in turn will act to process and/or generate optical data signals. In the construction of any system one encounters many problems which are associated with the fact that conventional optical fiber geometries are circular, whereas I.O. circuit geometries tend to be rectangular. Coupling from a circular to rectangular waveguide of small dimensions represents one of the outstanding problems in the technology today. A second problem and the subject of this paper is IO device performance degradation caused by propagating TE and TM modes simultaneously in the waveguide. By virtue of their rectangular construction, I.O. circuits possess a fixed axis with regard to which TE and TM modes are defined. There is no corresponding polarization axis in fibers of circular cross sections. As a result, the polarization of a light wave propagating through a fiber is usually not conserved. As has been previously shown, 1 linearly polarized light transmitted down circular fibers emerges as elliptically polarized light which when coupled to an IO device would excite both the TE and TM components. If the IO device possesses TE and TM components with different efficiencies, device degradation will result.