gebhart/patrepeval huggingface dataset:
PLCε Selectively Transduces Thrombin Versus LPA Signals to Astrocyte Proliferation Through Rap1 and Rho (2008)

Phospholipase C epsilon (PLCε) is a recently discovered PLC that, in contrast to other PLCs, responds directly to inputs from Ras and Rho family small G‐proteins. Using primary astrocytes isolated from a PLCε‐deficient mouse strain we show that endogenous G‐protein coupled receptors for LPA, S1P and thrombin utilize predominantly PLCε for inositol phosphate (InsP) and DAG formation. LPA‐ and S1P‐mediated InsP production was sensitive to Pertussis toxin (65±8% and 74±9% inhibition respectively) whereas the thrombin response was reduced by C3 toxin (68±13% inhibition), suggesting that these ligands activate PLCε through different mechanisms, a G i pathway for LPA and S1P and a Rho mediated pathway for thrombin. Thrombin stimulated [ 3 H]thymidine incorporation mediated by was markedly reduced in KO astrocytes (66±2%) and further studies revealed that PLCε is required for thrombin‐induced sustained ERK phosphorylation. Activation of a Ras family protein, Rap1, was required for ERK phosphorylation and DNA synthesis and the activation of this small G‐protein was abolished in KO cells. Notably LPA‐induced ERK and mitogenic effects were not Rap1 or PLCε dependent. Thus PLCε is selectively utilized by thrombin vs. LPA to transduce mitogenic signals through mechanism distinct from its role in generation of PLC‐derived second messengers. National Institute of Health Grant GM 36927 and GM 53536.
P.138L: Late‐News Poster : Accurate Evaluation of Light‐Extraction Efficiency for OLEDs with Light Out‐Coupling layers (2013)

Abstract We demonstrated that a light‐extraction efficiency of OLEDs was evaluated accurately by fitting an external quantum‐efficiency to a calculated optical‐mode. An internal quantum‐efficiency of 62.6% was obtained in the green OLED with thick electron transport layer. OLEDs with light out‐coupling layers exhibited a high light‐extraction efficiency of 76% and the estimated values were in good agreement with calculated ones.
Development of novel whole-mount in situ hybridization (WISH) (2002)

We have designed a novel fluorescent PNA probe which can be rapidly introduced into the living cell without any complicated pretreatment. We could post-synthetically incorporate amino acid derivatives having membrane permeability function into the PNA probe by utilizing key compound 1 which we have already developed. We show that the PNA probe will be a candidate for a rapidly penetrating and non-degrading probe for WISH.
A Report on the Mechanical Engineering Heritage (2018)

The present paper describes a procedure of the inclusion on The Mechanical Engineering Heritage list by JMSE, which has been done since 2008fy. After introducing method of determination for the inclusion of the list, task contents of the committee on the Mechanical Engineering Heritage, the Technology and Society Division of JSME are described. Urgent issue for the tasks, i.e. short of the manpower for the tasks (research and field study) for inclusion on the list, is pointed out.
In vehicle truck steering-system modeling and validation (2016)

In this paper a multi-body 44-DOF tractor semi-trailer model is coupled to a 4-DOF steeringsystem which includes friction and hydraulic power-steering.An extended wheel hub geometry is used to provide the correct feedback torque from the wheels.A tie-rod with stiffness has been included to connect left and right.An instrumented tractor semi-trailer is used to verify the steering-system model predictions during driving.The focus lies on the prediction of the steering-wheel torque and the vehicle velocity and steering-wheel angle are prescribed as an input for the simulation.Two tests are discussed in this paper, a J-turn at 80 km/h and sinusoidal steering-wheel input with a frequency of 0.4 Hz at 65 km/h.The comparison of the measured signals and the predicted values shows that the steering-system model is accurate.The non-linearities caused by friction and hydraulic assistance system can clearly be seen in both the measurement and the simulation.
Interface broadening due to Ar+ ion bombardment measured on Co/Cu multilayer at grazing angle of incidence (2003)

A Co/Cu multilayer system, with double layer thickness of about 60 nm was Auger electron spectroscopy depth profiled applying 1 keV Ar+ bombardment, varying the angle of incidence in the range of 78°–86°. It was found that (a) the relative sputter rate changes with the angle of incidence; (b) the interface broadening of the Co/Cu transition is larger than that of the Cu/Co transition and depends on the depth; (c) the broadening of the Co/Cu transition increases with increasing relative sputter rate; and (d) the broadening of the Cu/Co transition does not depend on the relative sputter rate. These features will be explained as the consequences of the strong preferential sputtering of Cu (with respect to Co) in this angular range. Because of the preferential sputtering ion bombardment induced roughening and smoothening (which was directly observed by atomic force microscopy measurements) occurs on the Co/Cu and Cu/Co interface, respectively. D-TRIM simulation has been also performed which suggested that ion mixing also causes larger broadening on the Co/Cu than on the Cu/Co interface.
SUBCHRONIC ADMINISTRATION OF PYRIDOSTIGMINE OR HUPERZINE TO PRIMATES: COMPARED EFFICACY AGAINST SOMAN TOXICITY (2002)

Organophosphonate (OP) nerve agents, such as soman, are potent irreversible inhibitors of central and peripheral acetylcholinesterases (AChEs). Pre-treatment of OP poisoning relies on the subchronic administration of a reversible AChE inhibitor. In the present limited study, the protective effects against soman toxicity of such compounds, i.e., the current pre-treatment pyridostigmine and huperzine, a proposed pre-treatment, are compared in primates. This is the first time primates are used to study the potential of pre-treatment with hyperzine. Indeed, previous studies with huperzine used nonprimate models which are not the most appropriate for pre-treatment in humans. Each medication is given via a subcutaneous mini-osmotic pump for 6 days at a delivery rate providing about 20% inhibition of red cell AChE activity. In this trial with only four primates, huperzine selectively inhibits red cell AChE activity whereas pyridostigmine also inhibits plasma butyrylcholinesterase (BuChE). This latter may act as endogenous scavenger of OP compounds helping to confer additional protection against OPs. During intoxication, the cumulative dose of soman needed to produce convulsions and epileptic activity is 1.55-fold higher in the animals pre-treated with huperzine compared to those pre-treated with pyridostigmine. Thus, replacing PYR by HUP for a subchronic pre-treatment of primates gives them better tolerance to the epileptic effects of soman.
A Composite Study of Onset of the Australian Summer Monsoon (1990)

Onset of the Australian summer monsoon is identified each year (1957–87) using the wind and rainfall record at Darwin. Onset is defined as the first occurrence of wet, 850 mb westerly winds. Composites of atmospheric fields at stations in and about the Australian tropics are constructed relative to the onset date at Darwin. The composite onset is accompanied by the development of a convectively driven, baroclinic circulation over northern Australia. Upper tropospheric easterlies expand about the equator and the subtropical jet shifts poleward at onset. This behavior is interpreted as a transient southerly shift of the local Hadley circulation concurrent with the development of an upper level anticyclone over northern Australia. The composite onset coincides with the arrival of an eastward propagating convective anomaly. The anomaly originates in the southern Indian Ocean, propagates eastward at 5 m s−1 and is detectable as far east as the date line. An eastward propagating zonal wind anomaly also is detectable at tropical stations east and west of Darwin. These features are indicative of the 40–50 day oscillation and thus the composite onset is concluded to coincide with the traversal of the oscillation across northern Australia. The composite onset is further shown to coincide with the first occurrence of the convectively active 40–50 day oscillation during each southern summer.
Template‐Directed Synthesis of Porous and Protective Core–Shell Bionanoparticles (2016)

Abstract Metal–organic frameworks (MOFs) are promising high surface area coordination polymers with tunable pore structures and functionality; however, a lack of good size and morphological control over the as‐prepared MOFs has persisted as an issue in their application. Herein, we show how a robust protein template, tobacco mosaic virus (TMV), can be used to regulate the size and shape of as‐fabricated MOF materials. We were able to obtain discrete rod‐shaped TMV@MOF core–shell hybrids with good uniformity, and their diameters could be tuned by adjusting the synthetic conditions, which can also significantly impact the stability of the core–shell composite. More interestingly, the virus particle underneath the MOF shell can be chemically modified using a standard bioconjugation reaction, showing mass transportation within the MOF shell.
Rescuing an orphan mineral collection; the case of the University of Newcastle mineral collection at the Hancock Museum (1999)

In late 1995 the mineral collection from the University of Newcastle Department of Geology was transferred to the Hancock Museum. For five years the collection had been stored in an unsuitable warehouse with a high relative humidity. The specimens, together with the original cabinets, were moved and carefully rehabilitated. The cabinets were reconstructed, while the specimens were cleaned, recatalogued and rehoused by staff of the Hancock assisted by members of the local branch of the Russell Society. The collection numbers nearly 7500 specimens some of which were collected by Arthur Russell and C.T. Trechmann, and represent material from the North Pennines in particular but also British and foreign localities.
Role of Gravity in the Formation of Liesegang Patterns (1996)

We report the results obtained in four different kinds of experiments designed to test the effect of gravity on the formation of Liesegang patterns. Both reacting solutions (KI and Pb(NO3)2) were gelled with agarose L. The position of the PbI2 precipitates was determined by image analysis, and the kinetic coefficients km = (Xn+1 − Xn)/Xn and kp = (Xn/A)1/n were obtained at different relative orientations of the gravitational field with respect to the direction of the advance of the precipitation front. We conclude that there is not an apparent influence of the gravitational forces on the kinetics of the pattern formation when it is obtained in gelled media at an agarose concentration of 1% (w/v). When the experiments were performed with agarose at 0.5% (w/v) or when one of the reacting solutions was ungelled, our tests show clearly the effect of gravity.
Chemical and Physical Methods to Analyze a Multicomponent Traditional Chinese Herbal Prescription Using LC-MS/MS, Electron Microscope, and Congo Red Staining (2013)

This study develops several chemical and physical methods to evaluate the quality of a traditional Chinese formulation, Jia-Wei-Xiao-Yao-San. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) coupled with electrospray ionization was used to measure the herbal biomarkers of saikosaponin A, saikosaponin D, ferulic acid, and paeoniflorin from this herbal formula. A scanning electron microscope (SEM) and light microscopy photographs with Congo red staining were used to identify the cellulose fibers if raw herbal powder had been added to the herbal pharmaceutical product. Moreover, water solubility and crude fiber content examination were used to inspect for potential herbal additives to the herbal pharmaceutical products. The results demonstrate that the contents of the herbal ingredients of saikosaponin A, saikosaponin D, ferulic acid, and paeoniflorin were around 0.351 ± 0.017, 0.136 ± 0.010, 0.140 ± 0.005, and 2.281 ± 0.406 mg/g, respectively, for this herbal pharmaceutical product. The physical examination data demonstrate that the raw herbal powder had rough, irregular, lumpy, filamentous, and elongated shapes, as well as strong Congo red staining. In addition, water solubility and crude fiber content were not consistent in the herbal pharmaceutical products.
An orange iridium(iii) complex with wide-bandwidth in electroluminescence for fabrication of high-quality white organic light-emitting diodes (2013)

A novel iridium(III) (pbi)2Ir(biq) with a strong orange emission at 573 nm was synthesized, which showed a high photoluminescence quantum yield (PLQY) of 45% in CH2Cl2 at 298 K. The quantum chemical calculations together with the photophysical properties indicated that the transition incorporation of 3MLCT (metal-to-ligand charge transfer), 3LLCT (ligand-to-ligand charge transfer) mixed with 3LC (ligand-centered 3π–π*) characters contributed to the emission of (pbi)2Ir(biq). Cyclic voltammetry (CV), thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) were then performed to investigate its electrochemical and thermal properties for fabrication of electroluminescent devices. Interestingly, complex (pbi)2Ir(biq) exhibited wide-bandwidth in electroluminescence (EL) of its orange electroluminescent devices, which made it effectively available to fabricate high-quality two-element white organic light-emitting diodes (WOLEDs). The resultant WOLED possessed a high current efficiency (ηc) of 22.1 cd A−1 and power efficiency (ηp) of 25.5 lm W−1 with a high color rendering index (CRI) of 80. Especially, the WOLED retained a favorable ηp of 10.9 lm W−1 and ηc of 16 cd A−1 at a high luminance of 1000 cd m−2. Moreover, it was worthwhile to note that this WOLED exhibited a qualified R9 of 13 and Duv of −0.0013, and these values together with the high CRI conformed to the required standard for lamp illumination of the ENERGY STAR.
Transfer Learning of Fuzzy Spatio-Temporal Rules in the NeuCube Brain-Inspired Spiking Neural Network: A Case Study on EEG Spatio-temporal Data (2023)

&lt;p&gt;EEG data collected from several subjects when perfoming complex spatio-temporal tasks &lt;/p&gt;
Protection of gerbils from amebic liver abscess by immunization with the galactose-specific adherence lectin of Entamoeba histolytica (1991)

No protective antigens from Entamoeba histolytica have been previously defined. We tested the ability of the galactose-specific adherence lectin of E. histolytica to elicit a protective immune response in conjunction with Freund's incomplete and complete adjuvants. The gerbil (Meriones unguiculatus) model of an experimental amebic liver abscess was used. Gerbils were immunized intraperitoneally or subcutaneously with 10 micrograms of the affinity-purified lectin in complete Freund's adjuvant and then at 2 and 4 weeks with 10 micrograms of the lectin in incomplete Freund's adjuvant. All of the immunized animals developed antilectin antibody titers of greater than 1/1,024 as measured by a radioimmunoassay. The gerbil antilectin antibodies were shown by Western immunoblotting to be directed to the heavy subunit but not the light subunit of the lectin. Immune gerbil sera inhibited amebic adherence by 100% at a 1/10 dilution. Immune and control gerbils were challenged at 6 weeks by the intrahepatic injection of 5 x 10(5) E. histolytica trophozoites. Four independent trials demonstrated complete protection from amebic liver abscess formation in 67% of lectin-immunized gerbils. Unexpectedly, liver abscess weights were significantly higher in the gerbils that failed to become immune than in the control animals. Our results demonstrate that the galactose lectin is a protective antigen and provide an immune-animal model to study the mechanisms of protection and potential disease exacerbation conferred by the antilectin immune response.
Photoelectrode Characteristics of Partially Hydrolyzed Aluminum Phthalocyanine Chloride/Fullerene C60 Composite Nanoparticles Working in a Water Phase (2012)

Photoelectrochemical measurements were used to study the photoelectrode characteristics of composite nanoparticles composed of fullerene C₆₀ and partially hydrolyzed aluminum phthalocyanine chloride (AlPc). In cyclic voltammetry measurements, the electrodes coated with the composite nanoparticles were found to have photoanodic [electron donor: 2-mercaptoethanol (ME)] and photocathodic (electron acceptor: O₂) characteristics similar to those of the vapor-deposited p/n junction electrode. Their photoanodic features were further investigated with respect to the transient photocurrent response to light irradiation and the dependence on ME concentration (under potentiostatic conditions), from which it was noted that there was a decrease in the initial spiky photocathodic current and saturation of the steady-state photoanodic current at a higher ME concentration. Thus, the reaction kinetics was probably dominated by charge transport process. Moreover, external and internal quantum efficiency spectrum measurements indicated that the composite nanoparticles responded to the full spectrum of visible light ( < 880 nm) for both the photoanodic and photocathodic current. The present research will assist comprehension of photocatalytic behavior of the composite nanoparticles.
Deamplification of pfmdr1 -Containing Amplicon on Chromosome 5 in Plasmodium falciparum Is Associated with Reduced Resistance to Artelinic Acid In Vitro (2010)

ABSTRACT Amplification of the Plasmodium falciparum multidrug resistance 1 gene ( pfmdr1 ) has been implicated in multidrug resistance, including in vitro resistance to artelinic acid (AL). The stability and fitness of having multiple copies of pfmdr1 are important factors due to their potential effects on the resistance phenotype of parasites. These factors were investigated by using an AL-resistant line of P. falciparum (W2AL80) and clones originating from W2AL80. A rapid reduction in pfmdr1 copy number (CN) was observed in the uncloned W2AL80 line; 63% of this population reverted to a CN of &lt;3 without exposure to the drug. Deamplification of the pfmdr1 amplicon was then determined in three clones, each initially containing three copies of pfmdr1 . Interestingly, two outcomes were observed during 3 months without drug pressure. In one clone, parasites with fewer than 3 copies of pfmdr1 emerged rapidly. In two other clones, the reversion was significantly delayed. In all subclones, the reduction in pfmdr1 CN involved the deamplification of the entire amplicon (19 genes). Importantly, deamplification of the pfmdr1 amplicon resulted in partial reversal of resistance to AL and increased susceptibility to mefloquine. These results demonstrate that multiple copies of the pfmdr1 -containing amplicon in AL-resistant parasites are unstable when drug pressure is withdrawn and have practical implications for the maintenance and spread of parasites resistant to artemisinin derivatives.
Carbon dioxide laser ablation combined with doxorubicin hydrochloride treatment for vaginal fibrosarcoma in a dog. (1992)

The combined use of CO2 laser ablation and doxorubicin hydrochloride (30 mg/m2) administered twice, 4 weeks apart, resulted in complete remission of vaginal fibrosarcoma in a 10-year-old Miniature Poodle. The tumor had redeveloped when only CO2 ablation was used for treatment and doxorubicin hydrochloride alone has had marginal influence on fibrosarcomas; however, use of both treatments in this dog resulted in a 20-month, disease-free period. This treatment combination was minimally traumatic to the dog, easily accomplished, and effective, and it allowed retention of the normal anatomy and function of the urogenital tract.
1003 Bed Comfort and Sleep: Change Your Bed Or Change Your Behavior? (2019)

We explored how bed comfort was related to self-report sleep patterns and perception of sleep. 3,007 adults (2,793 females) between the ages of 18 to 86, recruited through social media, completed a comprehensive online sleep assessment modified for mobile experience, including the Insomnia Severity Index (ISI), Epworth Sleepiness Scale (ESS), Sleep Hygiene Index, and questions about attempted sleep solutions. 20.4% of subjects reported sleeping on an uncomfortable bed either “always” or “frequently.” The perception of bed comfort was positively correlated with both age and income. 28% of subjects with household income less than $30,000 reported an uncomfortable bed compared with only 8.0% of subjects with incomes over $130,000. Participants who reported sleeping on an uncomfortable bed had significantly higher ISI scores (15.1 vs 16.9), p<0.001. Self-reported sleep onset latency (SOL) was associated with bed discomfort, with an average 20 minutes longer SOL for those that “always” sleep on an uncomfortable bed compared to “never.” Bed comfort was not associated with number or duration of night wakings. Nightmare frequency was also significantly higher for those that slept on an uncomfortable bed (1.62 nightmares/wk vs 0.91/wk, p<0.001). Bed discomfort was associated with daytime sleepiness with higher ESS scores (8.3 vs 9.5), p<0.001. Furthermore, reported bed comfort was significantly correlated with alertness at work (p<0.001). While bed discomfort is clearly associated with increased likelihood of insomnia, nightmares, and daytime sleepiness, we cannot know explicitly the direction of the causality. This is an important question that needs more exploration. Should individuals who report poor sleep and an uncomfortable bed begin by changing behaviors or changing their bed⋯ or both? Johnson & Johnson Consumer Inc., Skillman, NJ, USA. Somn Labs, Philadelphia, PA, USA
[History of oyster as drug from the origin to the 21st century]. (2015)

Since Antiquity, oyster is a subject of interest and medical use, as indicated by Oribiase and Galien. From the 17th century, this unique drug was proposed by physicians for various diseases, and more often for (la rage). One could think that that drug disappeared at the 20th and 21st centuries. But we can observe that it was still recommended by several authors as drug. Still today, companies offer oyster under various forms for allopathic and homeopathic treatments, as well as for food supplement. Research are ongoing to discover active substances within oyster and their potential medical interests.
Monitoring and Analysis Tools for Numeric and Log Data. (2015)

Abstract not provided.
Wave Propagation Phenomenon in Shuttling Transverse Combustion (2023)

View Video Presentation: https://doi.org/10.2514/6.2023-1494.vid In this paper, the shuttling transverse combustion (STC), a form of continuous detonation in wall-bounded geometry, is studied with a mixture of ethylene and oxygen. The interest is in the reflection of the wave propagation and how the reflections off the wall sustain the detonation process. Wave pressure measurements, high-speed electronically-excited hydroxyl radicals (OH*) chemiluminescence and schlieren imaging, together with numerical simulations are conducted to shed details on the reflection process for both the single wave (SW) and double wave (DW) modes. While the wave modes observed in the numerical simulations at similar conditions do not match up with the experiments, the observed phenomenon of localized “explosion in an explosion” in the simulations help to explain the presence of the curved shockwaves observed in the experiments for the SW mode. Preliminary findings indicated that the continuous detonation in STC for the SW mode consists of a sequence of localized explosions. For the DW mode, the fuel-rich conditions and high frequency affect the quality of the schlieren images.