gebhart/patrepeval huggingface dataset:
Assessment of the Release of Vascular Endothelial Growth Factor from 3D-Printed Poly-ε-Caprolactone/Hydroxyapatite/Calcium Sulfate Scaffold with Enhanced Osteogenic Capacity (2020)

Vascular endothelial growth factor (VEGF) is one of the most crucial growth factors and an assistant for the adjustment of bone regeneration. In this study, a 3D scaffold is fabricated using the method of fused deposition modeling. Such a fabricated method allows us to fabricate scaffolds with consistent pore sizes, which could promote cellular ingrowth into scaffolds. Therefore, we drafted a plan to accelerate bone regeneration via VEGF released from the hydroxyapatite/calcium sulfate (HACS) scaffold. Herein, HACS will gradually degrade and provide a suitable environment for cell growth and differentiation. In addition, HACS scaffolds have higher mechanical properties and drug release compared with HA scaffolds. The drug release profile of the VEGF-loaded scaffolds showed that VEGF could be loaded and released in a stable manner. Furthermore, initial results showed that VEGF-loaded scaffolds could significantly enhance the proliferation of human mesenchymal stem cells (hMSCs) and human umbilical vein endothelial cells (HUVEC). In addition, angiogenic- and osteogenic-related proteins were substantially increased in the HACS/VEGF group. Moreover, in vivo results revealed that HACS/VEGF improved the regeneration of the rabbit's femur bone defect, and VEGF loading improved bone tissue regeneration and remineralization after implantation for 8 weeks. All these results strongly imply that the strategy of VEGF loading onto scaffolds could be a potential candidate for future bone tissue engineering.
An Experimental Model for Evaluation of Antifungal Agents in a <i>Trichophyton mentagrophytes </i>Infection of Guinea Pigs (1984)

A Trichophyton mentagrophytes infection of guinea pigs induced by an occlusive procedure is described. The method of evaluation permits comparison of efficacy of antifungal agents which are not tested simultaneously. Activity was demonstrated following topical application of clotrimazole, miconazole, tolnaftate or griseofulvin and oral administration of griseofulvin. Oral ketoconazole had little effect in this dermatophyte model.
Translational Stroke Research: Vision and Opportunities (2020)

See related article, p 2341 Stroke risk and poststroke disability have steadily decreased in the United States over the past 2 decades because of improved prevention and access to reperfusion therapies for acute ischemic stroke, such as tPA (tissue-type plasminogen activator; alteplase) and endovascular thrombectomy. Despite the efficacy and safety of thrombolysis and thrombectomy, not all patients who receive the treatment improve to full, independent recovery, and most patients are ineligible for treatment. Additionally, there are no efficacious treatments to improve long-term outcomes for patients after the acute phase of ischemic stroke or to reduce brain injury induced by acute intracerebral hemorrhage. Therefore, development of new therapies for both acute and chronic stroke is sorely needed. Stroke occurs because of a variety of vascular pathologies and injury mechanisms, some of which are difficult to model in animals. With the exception of reperfusion therapy, preclinical research end points do not generally reflect clinical outcomes. Pharmacodynamics, pharmacokinetics, and target engagement in the human brain need to be further developed and optimized for stroke interventions so that drug level in brain tissue, time to initiation, and duration of treatment can be accurately measured in clinical trials. Many variables, such as heterogeneity of vascular pathologies, patient demographics, and a host of comorbid conditions, as well as the lack of validated biomarkers to stratify patient populations, limit the ability of typical stroke clinical trials to detect a treatment effect. To address these gaps, the National Institute of Neurological Disorders and Stroke organized and sponsored the workshop Translational Stroke Research: Vision and Opportunities, which was held in Bethesda, Maryland, on November 1 to 2, 2016. The workshop gathered over 180 registered participants from academia, industry, the Food and Drug Administration, and other public and private funding agencies. …
IMMU-52. SELECTION OF GLIOMA T-CELL THERAPY TARGETS BASED ON THE ANALYSIS OF TUMOR IMMUNOPEPTIDOME AND EXPRESSION PROFILES (2017)

Diffuse infiltrating low-grade gliomas (WHO grade II or III) are slow-growing primary brain tumors, but are considered malignant due to their invasive growth with a high risk of recurrence and progression to higher-grade tumors. While novel immunotherapeutic approaches are being developed, the paucity of well-characterized antigens that can be safely targeted remains a challenge; this led us to conduct an extensive evaluation searching for targetable T-cell epitopes in gliomas. In the current study, we report our analysis on a set of 64 glioma-associated antigens. Initial screening was based on the presentation of at least one of their epitopes by human leukocyte antigen (HLA)-A*0201 or A*2401 in primary glioblastoma tissue, their oncogenic role as proteins in glioma-genesis and their capability of inducing an antigen-specific T-cell response in human peripheral blood samples. Furthermore, we assessed differential expression of these epitopes in 39 primary gliomas paired with their corresponding recurrent tumors, and then evaluated datasets containing RNA expression levels for normal brain and other organs. As a result, we found 5 antigen epitopes being exclusively expressed in all WHO grade II gliomas, with even higher expression in their corresponding recurrent tumors, without significant levels measured in normal brain or peripheral organs. Our results strongly suggest that immunotherapy targeting these epitopes can be highly glioma-specific and safe, reducing the likelihood of adverse events such as on-target, off-tumor toxicity. These results are especially significant given the marked heterogeneity of gene and protein expression in gliomas. Moreover, our methods can be applied to increase the rate of discovery for neoantigens and naturally-occurring epitopes in this and other types of tumors.
Signal subspace approach to high‐resolution signal processing: The music algorithm (1986)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1986Signal subspace approach to high‐resolution signal processing: The music algorithmAuthors: Ralph SchmidtRalph SchmidtSaxpy Computer Corp.https://doi.org/10.1190/1.1892968 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1892968FiguresReferencesRelatedDetails SEG Technical Program Expanded Abstracts 1986ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1986 Pages: 715 publication data© 1986 Copyright © 1986 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 07 Mar 2005 CITATION INFORMATION Ralph Schmidt, (1986), "Signal subspace approach to high‐resolution signal processing: The music algorithm," SEG Technical Program Expanded Abstracts : 669-669. https://doi.org/10.1190/1.1892968 Plain-Language Summary PDF DownloadLoading ...
An information propagation scheme for VANETs (2005)

A goal in Vehicular Ad hoc Networks (VANETs) is to enable the dissemination of traffic and road conditions such as local congestion and surface ice as detected by independently moving vehicles.This activity known as Information Warning Functions is useful for vehicles on the highway and enables early reaction.This problem can be described as the directional propagation of information originating from linearly-distributed mobile nodes on a rectilinear plane.By using limited-range packet radios and attribute-based routing, we are able to isolate vehicular from network traffic and permit directional propagation of messages outward from the point of origin.For example, it is desirable to propagate the occurrence of congestion created by an accident in both the forward and backward directions on a highway.We assume the use of multi-hop routing in clusters of connected vehicles to achieve a propagation rate that exceeds the speeds of individual carrier vehicles.We characterize the bounds of information propagation under various traffic patterns and describe a new technique and algorithm that can achieve these limits.We also show an implementation of the dissemination algorithm as a routing protocol using a combination of MANET (mobile ad hoc networking) and DTN (delay tolerant networking) methodologies.
THE STEREOCHEMISTRY OF (-)HUMULONE (1970)

The absolute configuration of (–)humulone has been established and a formula is presented which gives a correct representation of this compound.
Behandlungsergebnisse an 25 Patienten mit endokriner Orbitopathie im Zeitraum zwischen 1998 und 2001 (2001)

In our outpatient clinic 25 patients with Graves' ophthalmopathy were treated, 21 women, mean age 58.8 years (range 19-74 years) and 4 men, mean age 47.5 years (range 38-56 years). In the female group two showed euthyroid Graves' ophthalmopathy and one Hashimoto's disease; in the male group one showed euthyroid ophthalmopathy. Treatment was done depending on the findings of the NOSPECS-classification in identical way for each group. Final results were obtained three and six months after therapy, at that time all patients were euthyroid. In five patients (two men and three women) sicca-treatment was sufficient because the ophthalmopathy improved by therapy of the thyroid disease only. Three women were treated by oral steroids over three months and had a complete remission. Nine women were treated by oral steroids and external radiation, six of them showed major improvement but in one case orbital decompression had to be done. Somatostatin therapy was done over six months in six women who showed no change after oral steroids plus radiation. Out of them five showed major improvement but in spite of a positive octreoscan in one case orbital surgery had to be performed. Two men were treated by oral steroids and external radiation without change of disease, somatostatin therapy was not done because of a negative octreoscan. With the exception of one nonsmoking woman in whom orbital surgery had to be done, the treatment results were worse in smokers.
Effectiveness Of Moringa Oleifera Coagulant Protein As Natural Coagulant Aid In Removal Of Turbidity And Bacteria From Turbid Waters (2010)

Coagulation of water involves the use of coagulating agents to bring the suspended matter in the raw water together for settling and the filtration stage. Present study is aimed to examine the effects of aluminum sulfate as coagulant in conjunction with Moringa Oleifera Coagulant Protein as coagulant aid on turbidity, hardness, and bacteria in turbid water. A conventional jar test apparatus was employed for the tests. The best removal was observed at a pH of 7 to 7.5 for all turbidities. Turbidity removal efficiency was resulted between % 80 to % 99 by Moringa Oleifera Coagulant Protein as coagulant aid. Dosage of coagulant and coagulant aid decreased with increasing turbidity. In addition, Moringa Oleifera Coagulant Protein significantly has reduced the required dosage of primary coagulant. Residual Al+3 in treated water were less than 0.2 mg/l and meets the environmental protection agency guidelines. The results showed that turbidity reduction of % 85.9- % 98 paralleled by a primary Escherichia coli reduction of 1-3 log units (99.2 – 99.97%) was obtained within the first 1 to 2 h of treatment. In conclusions, Moringa Oleifera Coagulant Protein as coagulant aid can be used for drinking water treatment without the risk of organic or nutrient release. We demonstrated that optimal design method is an efficient approach for optimization of coagulation-flocculation process and appropriate for raw water treatment.
Application of a Rapid Enzyme-linked Immunosorbent Microassay (ELISA) to Study Human Anti-insulin Antibody (1985)

A rapid, reproducible enzyme-linked immunosorbent assay (ELISA) for antibody to insulin is characterized and used to study antibodies from insulin-treated diabetic subjects. No radioactivity is involved in the ELISA; rather, peroxidase-conjugated anti-human immunoglobulin is used to detect binding of antibodies to insulin-coated microplates. Color is produced by action of peroxidase on a substrate and an automated reader then measures binding spectrophotometrically. This ELISA was optimized to be at least as sensitive as measurement of antibody by direct 125I-insulin binding. Although detection of IgG directly binding to insulin-coated plates in the ELISA does not reveal species-specific differences, avidity differences are shown in competitive inhibition with insulins from several species. Insulin-binding IgG was purified by affinity chromatography and used to construct a standard curve of the optical density (OD) in the ELISA relative to the concentration of antibody. This assay has been used to quantify and to characterize insulin antibody of sera from a large number of diabetic subjects, ranging from insulin resistant to those who had received only highly purified and human insulins. The assay is shown to be most useful to screen for insulin antibodies in resistant patients.
Comprehensive Characterization of Bovine Milk Lipids: Triglycerides (2020)

A comprehensive survey on triglycerides (TAGs) of bovine milk was conducted by a combination of exhaustive liquid chromatography (LC) separation, high-resolution mass spectrometry (MS) detection, and automated lipid molecular feature extraction. A total of 220 groups (a series of species having the same chemical formula and mass) and 3454 molecular species of TAGs were identified based on the accurate mass of the parent ion as well as MS2 information. Sixty-five different fatty acids (FAs) were found across these TAG species; C4:0, C6:0, C8:0, C10:0, C12:0, C14:0, C16:0, C18:0, and C18:1 were the most frequent FAs, whereas C11:3, C11:4, C27:0, C27:1, C28:0, and C28:1 were rare FAs in TAG molecules. The number of species identified represents only a small portion of total TAG molecules that can be theoretically synthesized from 65 FAs. Each TAG group contains on average 15-16 isomeric species (species with different FA composition), but positional isomers do not seem to be widespread. As the isomeric species cannot be completely resolved chromatographically, quantification of TAG was conducted at the group level. The most abundant TAG groups in bovine milk include TAG 34:0, TAG 36:0, TAG 38:1, TAG 38:0, and TAG 40:1. This study provides the most comprehensive milk TAG inventory so far that can be used as a reference for studying milk lipids.
The effect of traumatic injuries to primary teeth on their permanent successors (1971)

abstract – A material of 207 permanent teeth (including 90 cases collected from the literature), traumatized during’development by injuries to primary teeth, has been analyzed in a clinical, radiographic, histologic, microradiographic, and electron microscopic study. It appears from this examination that such developmental disturbances may be classified into distinct clinico‐pathologic entities, i.e. — (1) white or yellow‐brown discoloration of enamel, (2) white or yellow‐brown discoloration of enamel and horizontal enamel hypoplasia, (3) crown dilaceration, (4) odontome‐like malformation, (5) root duplication, (6) vestibular root angulation, (7) lateral root angulation or dilaceration, (8) partial or complete arrest of root formation, (9) sequestration of entire tooth germ, and (10) ectopic, premature, or delayed eruption or impaction.
Using Balanced Learning Course Design to Reduce Resistance to Diversity Curricula (2013)

Diversity content is often met with covert and overt resistance in the classroom. Utilisation of a balanced learning model may address classroom resistance. Balanced learning models require ‘backwards’ course planning, equal attention to course content and class process, and a strategic use of cyclical course design to include introduction of new materiel, experience, followed by personal reflection. Using a balanced learning model moves classroom instruction beyond active learning strategies in the classroom, but can present unique challenges for instructors. While not without challenges, utilising a balanced learning model proves useful during course design and delivery of a graduate course on diversity. The article describes balanced learning models emergence, define the benefits of such models, and ultimately demonstrate how using a balance learning model is a useful course design tool to reduce resistance to diversity content in the classroom.
Erratum: Spin-Liquid Correlations in the Nd-Langasite Anisotropic Kagomé Antiferromagnet [Phys. Rev. Lett.PRLTAO0031-900796, 197205 (2006)] (2006)

Received 18 November 2006DOI:https://doi.org/10.1103/PhysRevLett.97.259901©2006 American Physical Society
Modelling of ballistic missile defence from the sea (2014)

Ballistic missile warfare continues to present a significant threat in future conflicts due to its fast tempo and the ability to deliver weapons of mass destruction. The time for intercepting a hostile missile using ballistic missile defence is highly constrained, making workflow improvements necessary to compress the kill chain's duration. Full‐scale flight testing of realistic ballistic missile defence scenarios is difficult, if not impossible, and incurs prohibitive costs. This paper presents a process model of the missile defence sequence, consisting of searching, detecting, tracking, identifying targets, engaging, and damage assessment. The duty cycle of the task sequence executed by commanders and their staff is analysed by simulating the model to identify possible information‐processing bottlenecks and overloads under different operational modes of control for battle management. We subjected the model to various tests to generate leakage rate, interceptor consumption rate, and duration as measures of effectiveness. This capability allows for 'what‐if' evaluations of numerous concepts for command and control or task reallocation, complementing live Exercises and experiments. Future work could incorporate human performance and missile trajectory modelling to improve simulation accuracy.
Epidemiology and clinical pathophysiology of uric acid kidney stones (2014)

There is global diversity in the prevalence of uric acid (UA) nephrolithiasis. UA nephrolithiasis comprises 8-10 % of all kidney stones in the United States. However, its prevalence is higher in patients with type 2 diabetes mellitus and those with obesity. Three significant urinary abnormalities have been described as the main etiologic factors for the development of UA nephrolithiasis; low urinary pH, hyperuricosuria and low urinary volume. However, an unduly acidic urine below the ionization constant of uric acid (pKa < 5.5) increases the urinary content of undissociated uric acid and thereby uric acid precipitation. Previous studies have shown the two major pathogenic mechanisms for unduly urinary pH are increased net acid excretion (NAE) and reduced renal ammonium (NH4 (+)), with a combination resulting in overly acidic urine. The impaired ammonium excretion has been demonstrated in a steady state in 24-hour urine and also following an oral ammonium chloride (NH4Cl) challenge to amplify ammoniogenic defects in this population. Similar abnormalities have been disclosed in normal populations and also in T2DM populations without kidney stones. To date, the underlying mechanism of increased acid production, source and nature of putative organic acid anions have not been fully elucidated. One plausible mechanism is the production of organic acid by intestinal and aerobic metabolism. This may occur in obese, diabetic and uric acid stone formers due to the differences in gut microflora.
Synthesis of 2′‐Deoxy‐5‐(isothiazol‐5‐yl)uridine and Its Interaction with the HSV‐1 Thymidine Kinase (1996)

Abstract 2′‐Deoxy‐5‐(isothiazol‐5‐yl)uridine ( 12 ) was synthesized starting from 2′‐deoxy‐5‐iodouridine using a Pd‐catalysed cross‐coupling reaction with propiolaldehyde diethyl acetal followed by deprotection and ring closure using thiosulfate. 2′‐Deoxyuridine 12 has a particular place among the 5‐heteroaryl‐substituted 2′‐deoxyuridines in that it has a high affinity for herpes simplex virus type 1 (HSV‐1)‐encoded thymidine kinase (TK) without antiviral activity. Biochemical studies revealed that 12 is a substrate for viral TK. We further investigated the interaction of 12 with the HSV‐1 thymidine kinase. The conformation of 12 in solution was established by NMR spectroscopy. The most stable conformer 12A has the S‐atom of the isothiazole ring placed in the neighbourhood of the C(4)O group of the pyrimidine moiety. The compound was docked in its most stable conformation in the active site of HSV‐1 TK and subjected to energy minimization. This demonstrated that the isothiazole moiety binds in a cavity lined by the side chains of Tyr‐132, Arg‐163, Ala‐167, and Ala‐168 and that the C(3) atom of the isothiazole moiety is located in close proximity of the phenolic O‐atom of Tyr‐132 and the aliphatic part of the Arg‐163 side chain.
INFRARED TIRE INSPECTION TECHNIQUE (1973)

The non-destructive testing of tires to determine the presence of structural defects is accomplished in the patent application by means of a thermal imaging system including an infrared detector which moves about an arc transverse to the annular centroid of a rotating tire. Signals commensurate with heat build-up in the localized area on which the infrared sensor is focused, the position of the infrared detector and the rotational position of the tire are applied to and stored in a scan converter which, upon command, provides an image to a video monitor and recorder. Rapid heat build-up, commensurate with the presence of a defect, is determined by comparison of images generated during successive scannings.
A soup model study comparing flour peak viscosity during heating and viscosity of flour gels during reheating (1995)

A viscograph was used to study a model soft wheat flour-water gel system that was based on the apparent viscosity of commercial soups when reheated to a serving temperature of 60 o C. Unless flours were produced from highly field-sprouted wheats, there was no relationship between the hot paste peak viscosity attained during first heating and the viscosity of the same pastes that were allowed to gel, stored, and were then reheated to serving temperature. Sound, unsprouted flour produced hot paste peak viscosities as low as 57 BU (50 g of flour/450 ml of water) and consistently high reheated gel viscosities. Adding malted flour to the model system, reduced the hot paste peak viscosity much more than it reduced the viscosity of the reheated gels, especially at low levels of malt. The prediction of the viscosity at serving temperature of flour-thickened soups could be better accomplished using direct measurement of a-amylase activity or determination of the reheated gel viscosity rather than the viscograph hot paste peak viscosity
ChemInform Abstract: Optically Active Aromatic Amino Acids. Part 3. Synthesis of 3‐Cyano Derivatives of L‐Tyrosine. (1985)

Abstract Als Ausgangssubstanzen für die Synthese der Titelverbindungen (V) dienen der Methylether (Ia) bzw. das daraus erhältliche Phenol (Ib).