gebhart/patrepeval huggingface dataset:
The F-Box Protein AhSLF-S2 Controls the Pollen Function of S-RNase–Based Self-Incompatibility (2004)

Recently, we have provided evidence that the polymorphic self-incompatibility (S) locus-encoded F-box (SLF) protein AhSLF-S(2) plays a role in mediating a selective S-RNase destruction during the self-incompatible response in Antirrhinum hispanicum. To investigate its role further, we first transformed a transformation-competent artificial chromosome clone (TAC26) containing both AhSLF-S(2) and AhS(2)-RNase into a self-incompatible (SI) line of Petunia hybrida. Molecular analyses showed that both genes are correctly expressed in pollen and pistil in four independent transgenic lines of petunia. Pollination tests indicated that all four lines became self-compatible because of the specific loss of the pollen function of SI. This alteration was transmitted stably into the T1 progeny. We then transformed AhSLF-S(2) cDNA under the control of a tomato (Lycopersicon esculentum) pollen-specific promoter LAT52 into the self-incompatible petunia line. Molecular studies revealed that AhSLF-S(2) is specifically expressed in pollen of five independent transgenic plants. Pollination tests showed that they also had lost the pollen function of SI. Importantly, expression of endogenous SLF or SLF-like genes was not altered in these transgenic plants. These results phenocopy a well-known phenomenon called competitive interaction whereby the presence of two different pollen S alleles within pollen leads to the breakdown of the pollen function of SI in several solanaceaous species. Furthermore, we demonstrated that AhSLF-S(2) physically interacts with PhS(3)-RNase from the P. hybrida line used for transformation. Together with the recent demonstration of PiSLF as the pollen determinant in P. inflata, these results provide direct evidence that the polymorphic SLF including AhSLF-S(2) controls the pollen function of S-RNase-based self-incompatibility.
Accuracy of Intramedullary Versus Extramedullary Tibial Alignment Cutting Systems in Total Knee Arthroplasty (1995)

The postoperative standing 51-inch radiographs of 352 total knee arthroplasties were reviewed. The angle formed by the tibial tray to the mechanical axis of the tibia in the coronal plane was measured. The mean deviation from a perpendicular cut to the tibial mechanical axis was not significantly different between tibial cuts made with extramedullary alignment and with intramedullary alignment. With extramedullary alignment, 92% of the cuts were +/- 4 degrees of the ideal 90 degrees cut (perpendicular to the mechanical axis), whereas 94% of the cuts with intramedullary alignment were within 4 degrees of ideal. An analysis of the cuts that erred > or = 4 degrees with intramedullary alignment showed that for the majority the intra-medullary guide rod, if passed down the middle of the tibial shaft in the coronal plane, directly led to the less than ideal cut. In these tibias, bowing deformity in the coronal plane made passage of the intramedullary rod parallel to the tibial mechanical axis impossible.
A Constant Normal Stiffness Direct Shear Device for Static and Cyclic Loading (1987)

Abstract A device has been designed and built to carry out both static and cyclic direct shear tests on specimens of soil and rock and on interfaces of soil or rock and construction materials. The device has the special capability of allowing the shear deformation to proceed under conditions of constant normal stiffness. This is in contrast to the more conventional direct shear devices, which permit shearing under conditions of constant normal stress. It is expected that the constant normal stiffness conditions will be more representative of many in-situ conditions of shear deformation; an important example occurs at the interface of a pile and the formation in which it is placed (particularly those piles that are grouted into the formation). When used with a servo-controlled testing machine the device is capable of applying either static or cyclic shear loading to the test specimens utilizing either load or displacement control. The device is described in this paper, and typical results are presented for static and cyclic loading of a variety of interfaces including some that dilate on shearing and others that collapse as they are sheared.
Pristinamycin forRickettsia africaeInfection (2009)

African tick bite fever is caused by Rickettsia africae. The number of reported cases in international travelers has significantly increased recently. The gold standard treatment is doxycycline. Here, we present a case of R africae infection associated with quick complete resolution following the initiation of pristinamycin therapy.
Correlates to the variable effects of cannabis in young adults: a preliminary study (2012)

Cannabis can frequently have negative effects in its users, which can be amplified by certain demographic and/or psychosocial factors. Thus, users with a specific profile may be at a higher risk of unpleasant effects from cannabis use and caution should be noted when cannabis is administered to young people for medicinal purposes.
Covalently Bound Flavin in d‐6‐Hydroxynicotine Oxidase from Arthrobacter oxidans (1972)

A substituted riboflavin (HNO‐flavin) was isolated from d ‐6‐hydroxynicotine oxidase. It was obtained from flavin peptides by hydrolysis with 6 N HCl at 95°C or with aminopeptidase M. The riboflavin derivative had the spectral characteristics of 8α‐substituted flavins. It showed a pH dependence of fluorescence with a pK of 4.65 and 86%, quenching at pH 7. In thin‐layer chromatography it was identical with 8α‐( N ‐3‐histidyl)‐riboflavin. Hydrolysis of HNO‐flavin in 6N HCl at 125°C liberated 1 mol histidine per mol flavin as shown by amino acid analysis. Since FAD is the coenzyme of d ‐6‐hydroxynicotine oxidase, these results are taken as evidence that this enzyme contains 8α‐( N ‐3‐histidyl)‐flavin‐adenine dinucleotide in the active center.
Upstream bandwidth allocation supporting differentiated services in OFDMA PONs (2012)

An efficient scheduling algorithm has been proposed for upstream bandwidth allocation in OFDMA PON systems to support differentiated services. Simulation result illustrates that the proposed algorithm obtains high throughput performance and channel utility.
Effectiveness of a dedicated robot-assisted surgery training program. (2013)

A dedicated surgical training program focused on learning key steps of RAS enabled most participants to successfully incorporate and maintain their RAS skills in clinical practice.
Hospital competition and financial performance: the effects of ambulatory surgery centers (2010)

Ambulatory surgery centers (ASCs), limited-service alternatives for treating surgery patients not requiring an overnight stay, are a health-care service innovation that has proliferated in the U.S. and other countries in recent years. This paper examines the effects of ASC competition on revenues, costs, and profit margins of hospitals that also provided these services as a subset of their general services in Arizona, California, and Texas during the period 1997-2004. We identified all ASCs operating during the period in the 49 Dartmouth Hospital Referral Regions in the three states. The results of fixed effects models suggested that ASCs are meaningful competitors to general hospitals. We found downward pressure on revenues, costs, and profits in general hospitals associated with ASC presence.
A study of priority pricing in multiple service class networks (1991)

article Free Access Share on A study of priority pricing in multiple service class networks Authors: Ron Cocchi Computer Science Department, University of Southern California, Los Angeles, California Computer Science Department, University of Southern California, Los Angeles, CaliforniaView Profile , Deborah Estrin Computer Science Department, University of Southern California, Los Angeles, California Computer Science Department, University of Southern California, Los Angeles, CaliforniaView Profile , Scott Shenker Palo Alto Research Center, Xerox Corporation, Palo Alto, Ca Palo Alto Research Center, Xerox Corporation, Palo Alto, CaView Profile , Lixia Zhang Palo Alto Research Center, Xerox Corporation, Palo Alto, Ca Palo Alto Research Center, Xerox Corporation, Palo Alto, CaView Profile Authors Info & Claims ACM SIGCOMM Computer Communication ReviewVolume 21Issue 4Sept. 1991 pp 123–130https://doi.org/10.1145/115994.116005Online:01 August 1991Publication History 48citation668DownloadsMetricsTotal Citations48Total Downloads668Last 12 Months18Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Detection strategy for kidnapped robot problem in landmark-based map Monte Carlo Localization (2015)

This paper proposes a new method to detect the kidnapped robot problem event in Monte Carlo Localization. The method is designed such that it can provide accurate detection in wide range of particles' convergence level and does not depend too much on the re-localization/recovery process. The proposed method combines the difference in particle's weight, maximum current weight, and difference in particles' standard deviation. The addition of these two parameters is believed to be superior to a pure maximum current weight parameter for kidnapping detection. A series of simulation tests are executed to prove it. These simulations show that the proposed method outperforms the maximum current weight parameter in terms of accuracy, ability to detect kidnapping during early stage of localization, and independency towards the success of the re-localization process.
Lithography-driven layout of logic cells for 65-nm node (2003)

The ITRS roadmap for the 65nm technology node, targets poly gate lengths of 65nm and poly pitches between 140-180nm. In addition, contact overlaps and spacing to diffusion contacts will need to be scaled down. It is very likely that the poly layer will be printed using 193nm high NA steppers and Strong Phase Shift Technologies. Attempts to capture the effect of RET on layout by adding more constraints to the desing rules make it difficult to lay out cells using manual tools and can also lead to sub optimal designs. In this paper we describe a methodology that couples automatic cell generation with Phase shifter insertion and image simulation to allow the design space to be explored more fully.
Ex-vivo lung perfusion and ventilation: where to from here? (2019)

The future of EVLP involves usage of the system as a preservation modality, utilizing advanced diagnostics to predict transplant outcome, and performing therapeutic interventions to optimize organ quality. The generation of clinical data to facilitate and validate these approaches should be performed by transplant centers, which have acquired significant experience using EVLP within their clinical activity.
Patient Outcome after Surgical Management of an Accessory Nerve Injury (2002)

Functional deficit after accessory nerve injury is significant. Nerve graft/repair reconstruction reliably yields a satisfactory result, providing good scapular rotation and thus good shoulder function.
Effect of tobacco tar on Staphylococcus aureus and Candida albicans biofilm formation (2017)

Twenty compounds were determined in the tar of cigarette smoke. The tar was obtained using tobacco filters and then analyzed by liquid chromatography-mass spectrometry (LC-MS). Tobacco tar expressed marked decrease in the susceptibility of Staphylococcus aureus to penicillin, tetracycline and amoxicillin/clavulanic antibiotics and showed marked decrease in susceptibility of Candida albicans to the tested antifungals except for clotrimazole and ketoconazole. Tobacco tar decreased the permeability of the tested organisms to ethidium bromide in the presence of antimicrobials, after 2 h for both S. aureus (17.8-20%) and C. albicans (13.3-16.3%) and decreased the adherence of the tested microorganisms at concentrations above Minimal Inhibitory Concentration (MIC). Tobacco tar showed a marked increase in the hydrophobicity of the tested microorganisms by 2.5 to 7 fold. Tobacco tar increased or upregulated ALS1 and HWP1 genes that play an important role in adhesion, hyphae formation and biofilm formation of C. albicans and increased the expression of ica A gene that regulate biofilm formation of S. aureus. Key words: Tobacco tar, Staphylococcus aureus, Candida albicans, antimicrobial susceptibility, ethidium bromide, biofilm formation.
Characteristics of an electrostatically-driven gas valve under high-pressure conditions (2002)

We previously proposed a new type of electrostatically-driven gas valve enabling large conductance for rarefied gas conditions. In this paper, we report the capability of our gas valve under high pressure conditions on the order of several times the atmospheric pressure. For proper valve operation, the electrostatic force must prevail against the gas flow. We have experimentally examined the ultimate valve operation pressure difference which depends on the applied voltage and the port size. The valve works against a higher pressure difference when the port aperture size is smaller or the applied voltage is larger. A gas valve with a 45/spl times/45 /spl mu/m port aperture size successfully operates air of 0.3 MPa when the applied voltage is 250 V.
Studies on the biosynthesis of the oogoniols (1982)

In feeding experiments withAchlya heterosexualis, [3-(3)H] fucosterol was efficiently incorporated into oogoniols possessing an unsaturated side chain as well as those with a saturated side chain (clionasterol skeleton). [23,25-(3)H]-29-Hydroxyfucosterol was also efficiently incorporated into the oogoniols and its role as an intermediate in the biosynthesis was confirmed by a trapping experiment. This indicated the presence of a small pool of endogenous 29-hydroxyfucosterol in the mycelium. [23, 25-(3)H]-29-Oxofucosterol was also well incorporated into the oogoniols and it is probably an intermediate in the biosynthesis. It was found to be converted to 29-hydroxyfucosterol in a trapping experiment. Reduction of the C-24(28) double bond make take place after all the functional groups have been introduced, at C7, C-11 and C-15, in the tetracyclic structure.
Impact of Ammonium on Syntrophic Organohalide-Respiring and Fermenting Microbial Communities (2016)

Syntrophic interactions between organohalide-respiring and fermentative microorganisms are critical for effective bioremediation of halogenated compounds. This work investigated the effect of ammonium concentration (up to 4 g liter(-1) NH4 (+)-N) on trichloroethene-reducing Dehalococcoides mccartyi and Geobacteraceae in microbial communities fed lactate and methanol. We found that production of ethene by D. mccartyi occurred in mineral medium containing ≤2 g liter(-1) NH4 (+)-N and in landfill leachate. For the partial reduction of trichloroethene (TCE) to cis-dichloroethene (cis-DCE) at ≥1 g liter(-1) NH4 (+)-N, organohalide-respiring dynamics shifted from D. mccartyi and Geobacteraceae to mainly D. mccartyi. An increasing concentration of ammonium was coupled to lower metabolic rates, longer lag times, and lower gene abundances for all microbial processes studied. The methanol fermentation pathway to acetate and H2 was conserved, regardless of the ammonium concentration provided. However, lactate fermentation shifted from propionic to acetogenic at concentrations of ≥2 g liter(-1) NH4 (+)-N. Our study findings strongly support a tolerance of D. mccartyi to high ammonium concentrations, highlighting the feasibility of organohalide respiration in ammonium-contaminated subsurface environments. IMPORTANCE Contamination with ammonium and chlorinated solvents has been reported in numerous subsurface environments, and these chemicals bring significant challenges for in situ bioremediation. Dehalococcoides mccartyi is able to reduce the chlorinated solvent trichloroethene to the nontoxic end product ethene. Fermentative bacteria are of central importance for organohalide respiration and bioremediation to provide D. mccartyi with H2, their electron donor, acetate, their carbon source, and other micronutrients. In this study, we found that high concentrations of ammonium negatively correlated with rates of trichloroethene reductive dehalogenation and fermentation. However, detoxification of trichloroethene to nontoxic ethene occurred even at ammonium concentrations typical of those found in animal waste (up to 2 g liter(-1) NH4 (+)-N). To date, hundreds of subsurface environments have been bioremediated through the unique metabolic capability of D. mccartyi. These findings extend our knowledge of D. mccartyi and provide insight for bioremediation of sites contaminated with chlorinated solvents and ammonium.
Analytical Performance of the New Siemens Affinity Chrome-Mediated Immunoassay Everolimus Assay and Its Interchangeability With the Thermo Quantitative Microsphere System for Routine Therapeutic Drug Monitoring of Patients After Solid Organ Transplantation (2022)

ACMIA/EVRO shows satisfactory analytical performances that comply with recommendations, but it does not fulfill requirements for interchangeability with QMS/EVER. Particularly, this new assay using sirolimus-specific antibody shows a sizable proportional bias versus the more specific comparator, which may be because of EVL metabolites. This is supported by the lack of agreement for individual differences in most samples collected at the peak concentration (C2). Therefore, further evidence is needed to support the transition of EVL level monitoring from QMS/EVER to ACMIA/EVRO without making extensive changes to both reference interval and patient's baseline.
VARIABLE EFFECTS OF RU 486 ON ENDOMETRIAL MAINTENANCE IN THE LUTEAL PHASE EXTENDED BY EXOGENOUS hCG (1989)

This study was designed to assess the features and conditions for endometrial bleeding induction with the synthetic antiprogestin and antiglucocorticoid RU 486 during hCG-induced prolongation of the luteal phase. Eighteen healthy, surgically sterilized women and another five women with an intrauterine contraceptive device (IUD) participated. All subjects received hCG which was injected daily in increasing doses (500 to 15,000 IU) from day 9 to day 15 of the luteal phase. Ten subjects received hCG alone, and groups of three to 16 subjects received hCG combined with RU 486 (25, 50, 100, 200 or 400 mg/day). RU 486 administration was commenced on day 12 following the LH surge and given either for 1, 4 or 7 consecutive days. In certain cycles, tamoxifen (20 mg/day) was given for 4 consecutive days with hCG, or with hCG and RU 486. All treatment cycles were separated by one or two resting cycles. Frequent blood samples were taken to monitor the endocrine response. Treatment with hCG alone or with the various combinations of RU 486 produced similar serum levels of oestradiol and progesterone which were equivalent to those observed during early pregnancy. With hCG alone, the onset of bleeding was on day 21-24 after the LH surge, coinciding with the drop in oestradiol and progesterone. With RU 486 doses of 50 mg/day or more, an early bleeding episode almost invariably occurred on day 14-17 after the LH surge in the presence of high circulating steroid levels. In contrast, 25 mg/day RU 486 for 4 days failed to induce this early onset of bleeding in three out of six cases.(ABSTRACT TRUNCATED AT 250 WORDS)
Optic Neuritis (2019)

Optic neuritis is a common clinical manifestation of central nervous system inflammation. Depending on the etiology, visual prognosis and the risk for recurrent injury may vary. Rapid and accurate diagnosis of optic neuritis may be critical for limiting vision loss, future neurologic disability, and organ damage. This article will aid neurologists in formulating a systematic approach to patients with optic neuritis.
A Phase II Study of Antineoplastons A10 and AS2-1 in Adult Patients with Recurrent Glioblastoma Multiforme: Final Report (Protocol BT-21) (2014)

Treatment of recurrent glioblastoma multiforme (RGBM) creates one of the most difficult challenges to neuro-oncology. The purpose of this study is to evaluate the outcome of adults with high-grade glioma with special attention to RGBM patients treated with Antineoplastons (ANP) A10 and AS2-1 injections. The study was conducted according to Protocol BT-21, which accrued patients who failed standard radiation therapy (RT) and chemotherapy. There were 40 candidates registered in the study. Among the intent-to-treat (ITT) population, there were 30 cases of RGBM that progressed during and after prior treatment, 4 patients with anaplastic astrocytoma (AA), 1 with anaplastic mixed glioma (AMG), and 5 with persistent GBM. The aim of this paper is to evaluate the responses, survival and toxicity of all 40 patients, the efficacy in 30 patients with RGBM, and in 24 patients with RGBM who received at least 28 days of ANP (ERGBM). All RGBM patients were treated before with RT and chemotherapy, except one patient who only had surgery (patient refused radiation). In this group, 63% had one recurrence, 30% had two recurrences, and 7% had three recurrences. The median duration of ANP and ITT was 12 weeks and the median dosage of ANP A10 was 6.52 g/kg/d and ANP AS2-1 was 0.23 g/kg/d. Responses were assessed by gadolinium-enhanced magnetic resonance imaging (MRI) repeated every eight weeks. In the ITT population, objective responses (ORs) were determined in 10% of cases (complete response—CR, and partial response—PR in 5% each). Progression-free survival (PFS) in ITT at six months was 17.5%. Overall survival (OS) was 28.3% at one year, 2.6% at two years, five and ten years. In the RGBM population, objective responses (ORs) were determined in 13.3% of cases (CR and PR in 6.7% each). PFS in RGBM at six months was 16.7%. OS was 34.7% at one year, 3.47% at two years, five and ten years. In the ERGBM population, ORs were determined in 16.7% of cases (CR and PR in 8.3% each). PFS in ERGBM at six months was 20.8%, OS was 39.3% at one year, 4.4% at two years, five and ten years. The treatment was well-tolerated with reversible Grades 3 and 4 toxicity in 17.5% of patients (7 patients who experienced multiple toxicities) and no chronic toxicity. In conclusion, the study reached efficacy endpoint. ANP is well-tolerated and compares favorably to the current treatment for RGBM.