gebhart/patrepeval huggingface dataset:
Dynamin-independent CaV1.2 and KCa1.1 channels regulation and vascular tone modulation by the mitochondrial fission inhibitors dynasore and dyngo-4a (2023)

A role for mitochondrial fission in vascular contraction has been proposed based on the vasorelaxant activity of the dynamin (and mitochondrial fission) inhibitors mdivi-1 and dynasore. However, mdivi-1 is capable to inhibit Ba<sup>2+</sup> currents through Ca<sub>V</sub>1.2 channels (I<sub>Ba1.2</sub>), stimulate K<sub>Ca</sub>1.1 channel currents (I<sub>KCa1.1</sub>), and modulate pathways key to the maintenance of vessel active tone in a dynamin-independent manner. Using a multidisciplinary approach, the present study demonstrates that dynasore, like mdivi-1, is a bi-functional vasodilator, blocking I<sub>Ba1.2</sub> and stimulating I<sub>KCa1.1</sub> in rat tail artery myocytes, as well as promoting relaxation of rat aorta rings pre-contracted by either high K<sup>+</sup> or phenylephrine. Conversely, its analogue dyngo-4a, though inhibiting mitochondrial fission triggered by phenylephrine and stimulating I<sub>KCa1.1</sub>, did not affect I<sub>Ba1.2</sub> but potentiated both high K<sup>+</sup>- and phenylephrine-induced contractions. Docking and molecular dynamics simulations identified the molecular basis supporting the different activity of dynasore and dyngo-4a at Ca<sub>V</sub>1.2 and K<sub>Ca</sub>1.1 channels. Mito-tempol only partially counteracted the effects of dynasore and dyngo-4a on phenylephrine-induced tone. In conclusion, the present data, along with previous observations (Ahmed et al., 2022) rise caution for the use of dynasore, mdivi-1, and dyngo-4a as tools to investigate the role of mitochondrial fission in vascular contraction: to this end, a selective dynamin inhibitor and/or a different experimental approach are needed.
Cooperative adaptive cruise control over unreliable networks: an observer-based approach to increase robustness to packet loss (2018)

Cooperative Adaptive Cruise Control (CACC) is nowadays a promising technique to increase highway through-put, safety and comfort for vehicles. Enabled by wireless communication, CACC allows a platoon of vehicles to achieve better performance than Adaptive Cruise Control; however, since wireless is employed, problems related to unreliability arise. In this paper, we design a digital controller to achieve platoon stability, enhanced by an observer to increase robustness against packet losses. A preliminary set of simulation results is presented, which confirms the interest of using an observer in combination with a local and cooperative digital controller.
Representational Format, Student Choice, and Problem Solving in Physics (2005)

Student problem‐solving ability appears to be tied to the representational format of the problem (math, pictorial, graphical, verbal). In a study of a 367‐student algebra‐based physics class, we examine student problem solving ability on homework problems given in four different representational formats, with problems as close to isomorphic as possible. In addition, we examine students’ capacity for assessing their own representational competence by giving follow‐up quizzes in which the students can choose between various problem formats. We report student performance and consider factors that may influence their ability or choices. As a control, part of the class was assigned a random‐format follow‐up quiz where students received quiz formats at random. We find that there are statistically significant performance differences between isomorphic problems. We also find that allowing students to choose which representational format they use improves student performance under some circumstances and degrades it in others.
The Public Perception of the #GeneEditedBabies Event Across Multiple Social Media Platforms: Observational Study (2022)

This research provides evidence that posts on web-based platforms can offer insights into the public's stance on gene editing techniques. However, these stances vary across web-based platforms and often differ from those raised by academics and policy makers.
Inhibition of Cytosolic Phospholipase A2α Induces Apoptosis in Multiple Myeloma Cells (2021)

Cytosolic phospholipase A2α (cPLA2α) is the rate-limiting enzyme in releasing arachidonic acid and biosynthesis of its derivative eicosanoids. Thus, the catalytic activity of cPLA2α plays an important role in cellular metabolism in healthy as well as cancer cells. There is mounting evidence suggesting that cPLA2α is an interesting target for cancer treatment; however, it is unclear which cancers are most relevant for further investigation. Here we report the relative expression of cPLA2α in a variety of cancers and cancer cell lines using publicly available datasets. The profiling of a panel of cancer cell lines representing different tissue origins suggests that hematological malignancies are particularly sensitive to the growth inhibitory effect of cPLA2α inhibition. Several hematological cancers and cancer cell lines overexpressed cPLA2α, including multiple myeloma. Multiple myeloma is an incurable hematological cancer of plasma cells in the bone marrow with an emerging requirement of therapeutic approaches. We show here that two cPLA2α inhibitors AVX420 and AVX002, significantly and dose-dependently reduced the viability of multiple myeloma cells and induced apoptosis in vitro. Our findings implicate cPLA2α activity in the survival of multiple myeloma cells and support further studies into cPLA2α as a potential target for treating hematological cancers, including multiple myeloma.
Voltage-Induced Phase Shift in a Hybrid LiNbO3-on-Silicon Mach-Zehnder Interferometer (2013)

A hybrid Mach-Zehnder interferometer with directly bonded LiNbO3 on silicon-on-insulator waveguides is designed and demonstrated. The transfer function of the device shows a pi phase shift subject to an external field of 0.5 V/micro-meter
Direct Herbicide Application With an Autonomous Robot for Weed Control (2005)

An agricultural robot for weed control was developed and tested. The robot consisted of adigital video camera, two robotic arms, four wheels, a computer and a radio controller. The chemicalexperiments were done in both the fields and the greenhouses. The results showed that only a smallamount of regular spraying dosage was needed if chemicals were applied onto cut weeds directly.Velvetleaf, water hemp, foxtail and crabgrass were tested in the chemical experiments. Sincechemicals were mopped onto the weed's surface, there was no chemical droplet drift at all. There arealso a lot of benefits for the environment from these techniques.<br><br>The long-term objectives of this project are to develop an agricultural robot for weed control withautomatic navigation capability and higher efficiency.
Temperature Field and Current Rating 110 kV Cables in Different Laying Patterns of Chongqing Power Grid (2012)

After Chongqing has become the municipality directly under the central government,it develops fast and the electric power consumption increases dramatically.The construction of 110 kV cables also speeds up.In cable transmission,the load can not exceed the permissible ampacity,or the cable will overheat and cause accidents or reduce its service life.The paper has adopted the finite element method to calculate the temperature field distribution of the 110kV 800mm2 YJLW02 in different laying patterns and applied two-point secant method to calculate the current-carrying capacity.The result shows that the temperature of the cable core for installation in tunnel is the lowest,which is helpful to reduce the cable temperature,prolong its service life and increase its efficiency.
Video Content Adaptation Based on SVC and Associated RTP Packet Loss Detection and Signaling (2008)

The development of Scalable Video Coding (SVC) has been directed to serve a wide range of terminals over heterogeneous networks with the same encoded bit stream. SVC provides an elegant solution to adapt the video content, as it allows terminal and/or gateways accessing only a sub-part of the stream, without affecting the semantics of the source video signal. This paper describes adaptation mechanisms based on SVC, focusing on the implementation in the context of the IST project ENTHRONE. A particular emphasis is placed on adaptation techniques based on SVC NAL unit header extension, and on innovative RTP packet loss handling mechanisms, specifically conceived to handle losses in scenarios where SVC to SVC and SVC to H.264/AVC adaptation is performed and layered multicast cannot be used.
The Role of MicroRNA, miR‐24, and Its Target CHI3L1 in Osteomyelitis Caused by Staphylococcus aureus (2015)

Osteomyelitis is a debilitating infectious disease of the bone which is predominantly caused by Staphylococcus aureus (S. aureus). MicroRNAs (miRNAs) have been shown to play a regulatory role in osteogenesis. In the present study, the expression levels of miRNAs proposed to potentially play a regulatory role in bone formation or differentiation (miR-24, miR-29b, miR-200a, miR-208, miR-322) were analyzed in the whole blood of patients with bacterial osteomyelitis or healthy controls, and in MC3T3-E1 cells infected with S. aureus by qRT-PCR. The expression of miR-24 was significantly down-regulated in osteomyelitis patients and S. aureus-infected MC3T3-E1 cells compared with the healthy controls or untreated control cells. Moreover, our results showed that S. aureus inhibited MC3T3-E1 cell proliferation, induced osteoblast apoptosis and prohibited bone formation and mineralization. We found that overexpression of miR-24 could reduce the effects of S. aureus, while inhibition of miR-24 intensified the effects. We also demonstrated that miR-24 suppressed the expression of chitinase 3-like 1 (CHI3L1) mRNA, thought to mediate multiple signaling pathways, by directly binding to the 3'-untranslated region.
Sub Kilovolt Electrostatic Elastomer Actuator with Silver Nanowire Electrodes (2018)

Silver nanowires are used as a flexible electrode material on the elastic PDMS membrane of an electrostatic membrane actuator. The actuator system is designed in a modular way to promote a facile investigation of the influence of varying design parameters. Parameter simulations have been performed to achieve a high membrane center displacement at low applied voltages, compared to literature. The design properties were tested and verified in first experiments showing a membrane center displacement of over 100 μm at voltages above 4 kV [7].
Structural diversity of fructan in relation to the taxonomy of the Poaceae (1997)

summary To test the hypothesis that fructan structure can be used as a taxonomic character for the Poaceae we examined the accumulation of the linear, β‐2,6‐linked fructan series with a terminal glucose residue within the tribes Aveneae and Poeae. Only Dactylis glomerata L. (Poeae) has been shown to contain this series, making it unique among fructan structures and a potential taxonomic marker. To this end, 13 members of the tribes Aveneae and Poeae were surveyed for the presence of this fructan series by comparing extracts of water‐soluble carbohydrate by TLC with an extract of D. glomerata. The fructans of four species were similar to those of D. glomerata , as determined by TLC. Further comparison by anion‐exchange chromatography and linkage analysis demonstrated that Phalaris aquatica L., Puccinellia stricta (Hook, f.) C. H. Blom and Holcus lanatus L. contained a linear, β‐2,6‐linked series of fructan with a terminal glucose residue but that Lagurus ovatus L., although containing predominantly β‐2,6‐linked fructan was composed of more than one series of fructan, one with a terminal glucose residue and one with an internal glucose residue. A linear β‐2,6‐linked series of fructans with a terminal glucose residue was the dominant fructan accumulated by some species of genera belonging to both the Aveneae ( Phalaris and Holcus ) and the Poeae ( Dactylis and Puccinellia ). As both of these tribes also contain genera that accumulate fructans with an internal glucose residue, e.g. Avena and Lagurus (Aveneae) and Lolium (Poeae), structure of fructan cannot be used to distinguish these tribes. Review of the literature, however, showed that it is possible to separate the supertribes Triticodae and Poodae on the basis of the structure of the fructan that they accumulate.
Deep anisotropic etching of silicon (1999)

We are interested in etching very deep anisotropic trenches (∼100 μm) with high aspect ratios (depth/width) (∼20–50) and high etch rates (∼5 μm/min). A high density plasma helicon reactor using SF6/O2 chemistry and a cryogenic chuck has been used for etching very narrow trenches from 1.2 to 10 μm wide on n-type Si wafers with a SiO2 mask. The first results show significant features that demonstrate the feasibility of this method. Two-micron-wide trenches have been etched to a depth of 80 μm at an average etch rate of 2.7 μm/min. The resulting profiles are highly anisotropic and selectivity of Si/SiO2 is remarkably high (&amp;gt;500).
Hypertensive disorders of pregnancy: a UK-based perspective (2008)

King's College London, Division of Reproduction and Endocrinology, London, UK Correspondence to Dr Manju Chandiramani, Maternal and Fetal Research Unit, Department of Women's Health, 10th Floor North Wing, St Thomas' Hospital, Westminster Bridge Road, London, SE1 7EH, UK Tel: +44 20 7188 3634; fax: +020 7620 1227; e-mail: [email protected]
Quality of life improves after palliative placement of percutaneous tunneled drainage catheter for refractory ascites in prospective study of patients with end-stage cancer (2019)

QoL and symptoms improved after PTDC placement for refractory ascites in patients with end-stage malignancy. Decline in sodium and albumin values slowed postplacement. This study supports the use of a PTDC for palliation of refractory ascites in cancer patients.
Evidences for selection on promoter region reveal a hidden aspect of the multifaceted evolution of the type three effector Avrbs2 in the Xanthomonas axonopodis species (2011)

International audience
Burow’s solution in the treatment of active mucosal chronic suppurative otitis media: determining an effective dilution (2000)

Burow’s solution (13 per cent aluminium acetate) has been found to inhibit in vitro the growth of most commonly occurring bacteria found in the discharging ear. An in vitro study has shown that the minimum inhibitory concentration of Burow’s solution for these organisms lies between a 1:80 and a 1:160 dilution. This paper reports on a clinical trial that incorporated 67 discharging ears to establish the most effective strength of aluminium acetate solution. There was no statistical difference in the effectiveness of full strength Burow’s solution compared to 3.25 per cent aluminium acetate solution (a quarter strength Burow’s solution). Response rates of 80.8 per cent and 75 per cent respectively following a two-week treatment period were achieved using these two solutions. A 1.3 per cent aluminium acetate solution (1/10 strength Burow’s solution) was found to be markedly inferior. Bacteriological and audiological profiles were recorded for each patient.
Changes in the concentration of metabolites in milk from cows fed on diets supplemented with soyabean oil or fatty acids (1989)

Cows were fed on diets supplemented with soyabean oil or soyabean fatty acids which in some cases were protected from rumen hydrogenation. The fat-containing diets reduced the output of short- and medium-chain fatty acids in milk. Associated with this fall in short- and medium-chain fatty acids was a decrease in the concentration of 2-oxoglutarate and an increase in that of isocitrate and citrate. Protection of polyunsaturated fat from rumen hydrogenation had no significant effect. Milk yields were unaffected by diet, but the variation in milk yield among cows correlated positively with the concentration of glucose in milk.
An algorithm for high-speed 3-D profilometry (2011)

Structured light profilometers measure static object shapes but their measurement of moving objects is limited. We present a decoding algorithm which, when used with high-speed hardware, produces high-speed profilometry of general objects.
Oxidation of copper nanowire based transparent electrodes in ambient conditions and their stabilization by encapsulation: application to transparent film heaters (2018)

Whereas the integration of silver nanowires in functional devices has reached a fair level of maturity, the integration of copper nanowires still remains difficult, mainly due to the intrinsic instability of copper nanowires in ambient conditions. In this paper, copper nanowire based transparent electrodes with good performances (33 Ω sq<sup>-1</sup> associated with 88% transparency) were obtained, and their degradation in different conditions was monitored, in particular by electrical measurements, transmission electron microscopy, x-ray photoelectron spectrometry and Auger electron spectroscopy. Several routes to stabilize the random networks of copper nanowires were evaluated. Encapsulation through laminated barrier film with optical clear adhesive and atmospheric pressure spatial atomic layer deposition were found to be efficient and were used for the fabrication of transparent film heaters.
Angiotensin 1-7 Overexpression Mediated by a Capsid-optimized AAV8 Vector Leads to Significant Growth Inhibition of Hepatocellular Carcinoma In vivo (2018)

<b>Background:</b> Angiotensin-(1-7) [Ang-(1-7)] has been identified to inhibit the growth of many types of tumor cells both <i>in vitro</i> and <i>in vivo</i>. However, the rapid degradation of Ang-(1-7) <i>in vivo</i> limits its clinical application. Adeno-associated virus (AAV) serotype-8 is a remarkable vector for long-term <i>in vivo</i> gene delivery. <b>Method:</b> This study was designed to investigate the effects of AAV-mediated Ang-(1-7) overexpression on hepatocellular carcinoma. We first generated three different tyrosine (Y) to phenylalanine (F) mutants of AAV8 (Y447F, Y703F, Y708F) and evaluated their <i>in vivo</i> transduction efficiencies. <b>Results:</b> The data indicated that the Y703F mutant elicited a significant enhancement of liver gene delivery when compared with wild-type AAV8 (wtAAV8). The anti-tumor effect of Ang-(1-7) mediated by this optimized vector was evaluated in H22 hepatoma-bearing mice. Our results demonstrated that AAV-Ang-(1-7) persistently inhibited the growth of hepatocellular carcinoma by significantly downregulating angiogenesis. This was confirmed by observed decreases in the levels of the proangiogenic factors VEGF and PIGF. <b>Conclusion:</b> Collectively, these data suggest that Ang-(1-7) overexpression mediated by the optimized vector may be an effective alternative for hepatocellular carcinoma therapy due to its long-term and significant anti-tumor activity.
Taxol-stabilized Microtubules Can Position the Cytokinetic Furrow in Mammalian Cells (2020)

How microtubules act to position the plane of cell division during cytokinesis is a topic of much debate. Recently, we showed that a subpopulation of stable microtubules extends past chromosomes and interacts with the cell cortex at the site of furrowing, suggesting that these stabilized microtubules may stimulate contractility. To test the hypothesis that stable microtubules can position furrows, we used taxol to rapidly suppress microtubule dynamics during various stages of mitosis in PtK1 cells. Cells with stabilized prometaphase or metaphase microtubule arrays were able to initiate furrowing when induced into anaphase by inhibition of the spindle checkpoint. In these cells, few microtubules contacted the cortex. Furrows formed later than usual, were often aberrant, and did not progress to completion. Images showed that furrowing correlated with the presence of one or a few stable spindle microtubule plus ends at the cortex. Actin, myosin II, and anillin were all concentrated in these furrows, demonstrating that components of the contractile ring can be localized by stable microtubules. Inner centromere protein (INCENP) was not found in these ingressions, confirming that INCENP is dispensable for furrow positioning. Taxol-stabilization of the numerous microtubule-cortex interactions after anaphase onset delayed furrow initiation but did not perturb furrow positioning. We conclude that taxol-stabilized microtubules can act to position the furrow and that loss of microtubule dynamics delays the timing of furrow onset and prevents completion. We discuss our findings relative to models for cleavage stimulation.
Renal Mass and Hypertension (1978)

The paper describes an ontology-based approach for integrating interactive user modeling and learning content management to deal with typical adaptation problems, such as cold start and dynamics of the user’s knowledge, in the context of the Semantic Web. An integrated OntoAIMS system is presented and its viability discussed based on user studies. The work demonstrates some novel aspects, such as (a) ontological approach for integration of methods for eliciting and utilizing of user models; (b) improved adaptation functionality resulted from that integration, validated with real users; (c) support of interoperability and reusability of adaptive components.
A novel dual-frequency method for selective ultrasound imaging of targeted nanoparticles (2011)

Current methods for ultrasound (US) molecular imaging suffer the lack of image processing techniques specifically designed to identify the newer nanosized contrast agents (CAs). The available pulse sequences and signal analysis methods for US contrast detection, in fact, were developed for the older microbubble CAs, whose acoustic properties differ significantly from those of nanoparticles. This work illustrates the implementation and experimental testing of a new contrast detection scheme, tailored to enhance the contribution of solid nanosized CAs in echographic images. The proposed protocol, including a novel pulse sequence and a two-step image processing algorithm, was evaluated on a phantom consisting of silica nanospheres dispersed into an agarose gel matrix that was imaged through a conventional echographic transducer. Obtained results demonstrated the capability of selectively suppressing non-contrast echoes, without any loss in spatial resolution and maintaining the characteristics of real-time imaging, therefore showing very promising perspectives for clinical applications.