gebhart/patrepeval huggingface dataset:
Tailored Design and Synthesis of Heparan Sulfate Oligosaccharide Analogues Using Sequential One‐Pot Multienzyme Systems (2013)

Heparansulfat-Analoga: Hoch effiziente, chemoenzymatische Eintopf-Multienzym(OPME)-Systeme wurden zur Aktivierung und zum Transfer von N-Acetylglucosamin (GlcNAc) und Glucuronsäure (GlcA) entwickelt. Diese Systeme wurde für die sequentielle und maßgeschneiderte Synthese von N-sulfatierten Analoga von Heparansulfat-Oligosacchariden verwendet, die wirksame Therapeutika sein könnten. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Herpes simplex virus subunit vaccine: characterization of the virus strain used and testing of the vaccine. (1982)

Herpes simplex virus type 1 (HSV-1) used for vaccine production was isolated from a nasal recurrent infection and propagated over a limited number of passages in human diploid cells only. It was designated as HSV-1 BW3 and has been characterized by neutralizing antibodies as a typical HSV type 1 strain. In vitro transformation studies performed with this isolate in mouse or hamster cells revealed only very low, if any, transforming capacity. A preparation of HSV-1 BW3 which can be used as seed lot for vaccine production has been proven to be free of any adventitious agents such as bacteria, fungi mycoplasma or viruses other than HSV-1 BW3. An envelope antigen (EAG) preparation was obtained from purified HSV-1 particles. It was free of detectable viral DNA and could be proven to be efficacious in mouse models against challenge infections with either HSV-1 or HSV-2. The potency of the vaccine was greatly enhanced by the addition of poly-inosinic-poly-cytidylic acid complexed with poly L-lysine and carboxymethylcellulose (PICLC) as adjuvant. A single vaccine dose was sufficient to protect mice from morbidity and the fatal outcome of HSV infection, but not from the establishment of latency. Persistent ganglionic infections could be, however, significantly reduced by repeated administration of the vaccine before primary infection.
Effects of rapid tryptophan depletion on brain 5-HT2receptors: a PET study (2001)

When taken with the evidence that antidepressant treatment is associated with a decrease in brain 5-HT(2) receptors, these findings suggest that a decrease in 5-HT(2) binding following RTD might be an adaptive response that provides protection against depressive symptoms.
Role of tachykinin NK2 receptors in normal and altered rectal sensitivity in rats (2000)

Irritable bowel syndrome is characterized by visceral hyperalgesia commonly associated with stress and inflammatory processes. We investigated the role of tachykinin NK2 receptors in the ability of trinitrobenzenesulphonic acid (TNBS) and stress to enhance the sensitivity of the rat rectum to distension using a selective tachykinin NK2 receptor antagonist (MEN 11420). Rats were fitted with electrodes implanted in the striated muscles of the abdomen. Rectal distension (RD) was performed with a balloon inflated by steps of 0.4 ml from 0 to 1.6 ml. Five groups were submitted to RD performed 3 days before and after intrarectal instillation of TNBS. Fifteen minutes before RD, rats were treated with saline or MEN 11420 (5 - 100 microg kg(-1) i.v.). Two other groups, submitted to 2 h restraint or sham stress sessions were randomly treated i.v. with saline or MEN 11420 (10 - 200 microg kg(-1)) prior to RD applied 20 min later. The basal response to RD was characterized by a significant increase in the number of abdominal contractions. This response occurred with a threshold volume of 0.8 ml and was dose-dependently reduced by MEN 11420 (5 - 100 microg kg(-1) i.v.). Rectal inflammation lowered the volume of distension producing abdominal contractions to 0.4 ml (allodynia). This effect was either reduced or suppressed by MEN 11420. A similar allodynia was observed after a stress session and this effect was reduced (49%) or suppressed by MEN 11420 at 200 and 100 microg kg(-1), respectively. Tachykinin NK2 receptors are involved in rectal hypersensitivity associated with inflammation and stress. British Journal of Pharmacology (2000) 129, 193 - 199
The Use of Electronic Computers to Aid in Medical Diagnosis (1959)

With the use of computers several mathematical techniques can be applied to aid certain aspects of medical diagnosis. However, much work remains to be accomplished in trying these methods under practical conditions. Although wide interest has been expressed, few studies have been reported in the literature. Among the potential advantages of computer aids are: making available to the physician quantitative methods in areas related to data analysis and differential diagnosis; assisting in the evaluation of the best alternative courses of action during stages of the diagnostic testing processes; and periodic recording and evaluating of individual physiologic norms for more sensitive determination of an individual's health trend relative to disease prevention. Communication between the physician or researcher and the computer is presently technically feasible but much research and planning are still required for realistic application.
Data-driven attitude control law of a variable-pitch quadrotor: a comparison study (2016)

In this paper, the problem of tuning a cascade attitude control system of a variable-pitch quadrotor UAV is tackled, comparing two non-iterative data-driven approaches. The first method is the Virtual Reference Feedback Tuning (VRFT) while the second one is the Correlation based Tuning (CbT), both modified in order to tune both the inner and the outer loops by means of a single set of experimental data. These methods allow a fast tuning of controller parameters directly from data, without relying on an accurate knowledge of the plant dynamics. The experimental tests are performed on a variable-pitch quadrotor which operates indoor on a dedicated test bench that allows only the pitch attitude degree of freedom of the vehicle.
Cyclic AMP Concentrations in Follicular Fluids: Relationship to Outcomes of In Vitro Fertilization Cycles (1988)

Follicular fluids and their matched oocytes were obtained from 16 follicles of 7&#13;\nwomen who conceived after in vitro fertilization(IVF), and 49 follicles of 17 women who failed&#13;\nto conceive after the procedure. Follicular development was induced with a combination of&#13;\nfollicle-stimulating hormone and human menopausal gonadotropin.&#13;\nThere was no significant difference in follicular cyclic AMP concentrations between preovulatory&#13;\nand immature oocytes. However, follicles of preovulatory oocytes obtained from women&#13;\nwho conceived after IVF contained lower cyclic AMP concentrations than those from women&#13;\nwho failed to conceive after the procedure. Follicles of cleaved oocytes from pregnant women&#13;\ncontained lower cyclic AMP concentrations than those of cleaved oocytes from nonpregnant&#13;\nwomen or all uncleaved oocytes.&#13;\nThese results suggest that lower cyclic AMP concentrations in follicular fluids are associated&#13;\nwith successful pregnancies in IVF cycles.
Decomposition of Permutation Networks (1973)

The problem of decomposing an arbitrary permutation of a large number of elements into a number of permutations of smaller numbers of elements has become important recently in rearrangeable switching networks and in interconnectors for computer peripheral and processing units. Opferman and Tsao-Wu have published an algorithm for decomposing an arbitrary permutation of n = d × q elements into d permutations of q elements each and (2q - 1) permutations of d elements each. The following is a modified version of their algorithm, wherein a matrix, called the allocator matrix, each of whose elements is a set of integers, is used for obtaining the d permutations of q elements each; and a simpler way of obtaining the (2q - 1) permutations of d elements each is given. The modified algorithm is similar to the backtrack procedure in combinatorics and leads directly to an APL program for any divisor d of n.
System-level analysis of single event upset susceptibility in RRAM architectures (2016)

In this work, the single event upset susceptibility of a resistive random access memory (RRAM) system with 1-transistor-1-resistor (1T1R) and crossbar architectures to heavy ion strikes is investigated from the circuit-level to the system-level. From a circuit-level perspective, the 1T1R is only susceptible to single-bit-upset (SBU) due to the isolation of cells, while in the crossbar, multiple-bit-upsets may occur because ion-induced voltage spikes generated on drivers may propagate along rows or columns. Three factors are considered to evaluate system-level susceptibility: the upset rate, the sensitive area, and the vulnerable time window. Our analysis indicates that the crossbar architecture has a smaller maximum bit-error-rate per day as compared to the 1T1R architecture for a given sub-array size, I/O width and susceptible time window.
Deep Autoencoder for Identification of Abnormal Gait Patterns Based on Multimodal Biosignals (2021)

Gait abnormality is a common problem in humans after any lower limb injury or a stroke attack. The detection of abnormal gait is an important measure for designing and following appropriate rehabilitation protocol. This study presents a model for identifying the abnormal gait patterns for knee injured subjects based on a deep autoencoder neural network. The model employed micro-electro-mechanical motion sensors (MEMS) and electromyography (EMG) system to collect the joints motion and neuromuscular signals, respectively. The important kinematics and EMG features were extracted from the collected data and autoencoder models (single and multilayer) were trained using the features of normal gait data. Various parameters and hyperparameters for the models were explored and fine-tuned during the training phase. Later, the best trained models along with a thresholding method were used to detect the abnormal gait patterns. The performance of the single and multilayer (deep) autoencoder models have been compared and reported for the data sets. The deep autoencoder model was able to identify the abnormal gait patterns with higher accuracy (98.3%) and area under curve (99.2%) values as compared to existing models. The proposed model can serve as a decision support system for clinicians, physiatrists and physiotherapists for detecting abnormal gait automatically.
The CircumVent Project: a CPAP/O2 helmet solution for non-invasive ventilation using an implementation research framework (2021)

NCT04929691. Registered June 18, 2021-retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT04929691.
Vers une gestion de groupe sécurisée dans les réseaux ad hoc militaires (2006)

National audience
Human-inspired robot task learning from human teaching (2008)

The ability of a service or personal robot to learn new tasks from human teaching is important if it is to be multi-functioning and serve users a lifetime. Considering the vast variation of tasks, work environments, and nature of potential teachers or users who may not have knowledge in robotics, the problem of task teaching and learning can be difficult to achieve. Current methods of robot teaching and learning do not yet enable the robot to learn different types of tasks from the teaching by a general user. This paper presents a human-inspired method of robot task learning from human instructive hand-to-hand teaching. The method is novel in including an introduction of the complete task to the robot before task demonstration, a voting algorithm for segmenting the demonstrated task trajectory, and a Bayesian approach to assign partitioned trajectory segments to subtasks. Also, the proposed trajectory blending scheme can generate actual task paths in real-time to adapt learned tasks to new task setups.
Advanced Combustion Numerics and Modeling - FY19 First Quarter Report (2018)

This project is focused on early stage research and development of numerical methods and models to improve advanced engine combustion concepts and systems. The current focus is on the development of new mathematics and algorithms to reduce the time to solution for advanced combustion engine design using detailed fuel chemistry. The research is prioritized towards the most time-consuming workflow bottlenecks (computer and human) and accuracy gaps that slow ACS program members. Zero-RK, the fast and accurate chemical kinetics solver software developed in this project, is central to the research efforts and continues to be developed to address the current and emerging needs of the engine designers, engine modelers and fuel mechanism developers.
Multi-Channel Capacitive Sensor Arrays (2016)

In this paper, multi-channel capacitive sensor arrays based on microstrip band-stop filters are studied. The sensor arrays can be used to detect the proximity of objects at different positions and directions. Each capacitive sensing structure in the array is connected to an inductive element to form resonance at different frequencies. The resonances are designed to be isolated in the frequency spectrum, such that the change in one channel does not affect resonances at other channels. The inductive element associated with each capacitive sensor can be surface-mounted inductors, integrated microstrip inductors or metamaterial-inspired structures. We show that by using metamaterial split-ring structures coupled to a microstrip line, the quality factor of each resonance can be greatly improved compared to conventional surface-mounted or microstrip meander inductors. With such a microstrip-coupled split-ring design, more sensing elements can be integrated in the same frequency spectrum, and the sensitivity can be greatly improved.
Pathway Optimization of 2′-Fucosyllactose Production in Engineered Escherichia coli (2021)

2'-Fucosyllactose (2'-FL), one of the most valuable oligosaccharides in human milk, is used as an emerging food ingredient in the nutraceutical and food industries due to its numerous health benefits. Herein, the <i>de novo</i> and salvage pathways for GDP-fucose synthesis were engineered and optimized in <i>Escherichia coli</i> BL21 (DE3) to improve the production of 2'-FL. The <i>de novo</i> pathway genes encoding phosphomannomutase (ManB), mannose-1-phosphate guanyltransferase (ManC), GDP-d-mannose-4,6-dehydratase (Gmd), and GDP-l-fucose synthase (WcaG) combined with the gene from the salvage pathway encoding fucose kinase/fucose-1-phosphate guanylyltransferase (Fkp) were reconstructed in two vectors to evaluate the GDP-fucose biosynthesis. Then, the <i>fucT2</i> gene, encoding α1,2-fucosyltransferase, was introduced into the GDP-fucose-overproducing strains to realize 2'-FL biosynthesis. Furthermore, the genes in bypass pathways, including <i>lacZ</i>, <i>fucI</i>, <i>fucK</i>, and <i>wcaJ</i>, were inactivated to improve 2'-FL production. In addition, the two GDP-fucose synthesis pathways, along with <i>fucT2</i>, were transcriptionally fine-tuned to efficiently increase 2'-FL production. The final metabolically engineered <i>E. coli</i> produced 2.62 and 14.1 g/L in shake-flask and fed-batch cultivations, respectively.
Evaluation of the Screwworm Adult Suppression System (SWASS) on the Island of Curacao13 (1978)

Journal Article Evaluation of the Screwworm Adult Suppression System (SWASS) on the Island of Curacao Get access J. R. Coppedge, J. R. Coppedge Search for other works by this author on: Oxford Academic PubMed Google Scholar J. L. Goodenough, J. L. Goodenough Search for other works by this author on: Oxford Academic PubMed Google Scholar A. B. Broce, A. B. Broce Search for other works by this author on: Oxford Academic PubMed Google Scholar F. H. Tannahill, F. H. Tannahill Search for other works by this author on: Oxford Academic PubMed Google Scholar J. W. Snow, J. W. Snow Search for other works by this author on: Oxford Academic PubMed Google Scholar M. M. Crystal, M. M. Crystal Search for other works by this author on: Oxford Academic PubMed Google Scholar H. Del Var Petersen H. Del Var Petersen Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Economic Entomology, Volume 71, Issue 4, 1 August 1978, Pages 579–584, https://doi.org/10.1093/jee/71.4.579 Published: 01 August 1978 Article history Received: 23 January 1978 Published: 01 August 1978
Abstract P3-14-07: A Phase 1 Study To Assess the Safety, Tolerability and PK of ARRY-380 — An Oral HER2 Inhibitor (2010)

Abstract Background: ARRY-380 is a potent, orally active small molecule that selectively inhibits HER2 signaling in vitro and in vivo. Methods: Patients (pts) with HER2+ MBC or other tumor types with published evidence of HER2 expression were treated with ARRY-380 as a single oral dose on C1 D1 followed by continuous dosing on C1 D3, in a BID schedule. Dose escalation was performed using standard DLT rules after all pts within a cohort completed the first cycle. Serial PK assessments were performed on D 1, 2, 3 and on D 15 of C1. Preliminary Results: As of 1 June, 2010, 30 pts have been treated at doses ranging from 25 mg to 800 mg BID. Pts had a median age of 57 years (range: 31-77 years). Cancer types included HER2+ MBC (n=23), CRC (n=6), and salivary gland (n=1). All HER2+ MBC pts had received prior trastuzumab and most (78%) had received prior lapatinib. The MTD (600 mg BID) has been determined in the dose escalation study. ARRY-380 was generally well-tolerated. One DLT of reversible grade 3 AST and one DLT of reversible grade 3 AST/ALT were noted at the 800 mg BID dose level. Other related AEs have been predominantly mild and include Grade 1 nausea, rash, and fatigue and Grade 2 fatigue. No treatment-related cardiac events have been reported. PK analyses indicate a trend for increasing Cmax and AUC with increasing dose, a median Tmax of 2 hours, and a mean t1/2 of 5.3 hours across doses. Of the 15 HER2+ MBC pts evaluable for response at doses ≥200 mg BID, 1 (7%) pt had a confirmed PR and 8 (53%) had SD accompanied by regression of tumor lesions. Of the 8 pts with SD, 5 pts demonstrated SD for ≥4 months. The rate of PR + SD ≥4 months was 43%. The HER2+ MBC pt with a PR had complete regression of all target and non-target lesions and a change in CEA from 71.1 to 3.5 ng/mL [NR = 0.0-3.0 ng/mL]. This pt is currently in Cycle 5 and has received 6 prior lines of therapy for advanced disease with a best response of PD on lapatinib. Conclusions: ARRY-380 has demonstrated a generally well-tolerated safety profile with a low incidence and severity of rash and diarrhea. ARRY-380 has shown promising signs of antitumor activity in a heavily pretreated HER2+ MBC population (43% of pts with PR or SD ≥4 months). These safety and preliminary efficacy data compare favorably to historical data of other HER2-targeted agents. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P3-14-07.
Sensor Allocation and Online-Learning-based Path Planning for Maritime Situational Awareness Enhancement: A Multi-Agent Approach (2023)

Countries with access to large bodies of water often aim to protect their maritime transport by employing maritime surveillance systems. However, the number of available sensors (e.g., cameras) is typically small compared to the to-be-monitored targets, and their Field of View (FOV) and range are often limited. This makes improving the situational awareness of maritime transports challenging. To this end, we propose a method that not only distributes multiple sensors but also plans paths for them to observe multiple targets, while minimizing the time needed to achieve situational awareness. In particular, we provide a formulation of this sensor allocation and path planning problem which considers the partial awareness of the targets' state, as well as the unawareness of the targets' trajectories. To solve the problem we present two algorithms: 1) a greedy algorithm for assigning sensors to targets, and 2) a distributed multi-agent path planning algorithm based on regret-matching learning. Because a quick convergence is a requirement for algorithms developed for high mobility environments, we employ a forgetting factor to quickly converge to correlated equilibrium solutions. Experimental results show that our combined approach achieves situational awareness more quickly than related work.
Preparation of macrocyclic di‐ and tetraamides containing unsubstituted macroring nitrogen atoms, tertiary amine sidearms and/or piperazine subcyclic units (1990)

Abstract Seven new macrocyclic di‐ and tetramides have been prepared by the cyclization reaction of various polyamines or, in one case, a dimercaptan with a bis(α‐chloroamide) or diethyl malonate. Three of the resulting macrocyclic diamides were reduced with borane to form the corresponding polyaza‐crown analogs. Macrocycles prepared include two tetraaza‐12‐crown‐4, two tetraaza‐13‐crown‐4, two tetraaza‐14‐crown‐4, one dithiadiaza‐14‐crown‐4, one tetraaza‐15‐crown‐4 with a piperazine subcyclic group, one dibenzotetraaza‐24‐crown‐8 and one octaaza‐30‐crown‐8 with two piperazine subcyclic groups.
Central Administration of Oleic Acid Inhibits Glucose Production and Food Intake (2002)

The hypothalamus and other regions within the central nervous system (CNS) link the sensing of nutrients to the control of metabolism and feeding behavior. Here, we report that intracerebroventricular (ICV) administration of the long-chain fatty acid oleic acid markedly inhibits glucose production and food intake. The anorectic effect of oleic acid was independent of leptin and was accompanied by a decrease in the hypothalamic expression of neuropeptide Y. The short-chain fatty acid octanoic acid failed to reproduce the metabolic effects of oleic acid, and ICV coadministration of inhibitors of ATP-sensitive K(+) channels blunted the effect of oleic acid on glucose production. This is the first demonstration that fatty acids can signal nutrient availability to the CNS, which in turn limits further delivery of nutrients to the circulation.
Diode-pumped industrial high-power cw all-solid state laser at 266 nm (1999)

The first cw high-power deep UV laser at 266 nm is accomplished by an intracavity frequency doubled and externally quadrupled diode-pumped Nd:YAG laser. The quadrupling stage is an actively stabilized unidirectional ring cavity based on the patent-pending DeltaConcept, where a minimum number of optical components--two mirrors and one prism are used. The symmetrical Brewster-angled beam path through the prism guarantees minimum losses and hence maximum power enhancement and efficiency. The cavity length control is done by moving the prism along its symmetry axis using a piezoelectric element. The beam path in the cavity remains not only completely unaffected during this movement but also unaffected in the first order by small tilts of the prism due to possible imperfection of the piezoelectric element. Furthermore, the stabilization loop has excellent dynamic behavior owing to the small mass of the prism. Minimum losses result in a power enhancement up to 150. The unique feature of the DeltaConcept shown above adopted in the 266 nm laser results in high beam pointing stability of &lt; 2 (mu) rad/ degree(s)C and long term deep UV power stability of &lt; 2% over 10 hours. By using Brewster-cut BBO crystals the high-power deep UV cw laser can deliver 266 nm radiation with an output power of 1.5 Watt at a green pumping power of 5 W. First slim design of the whole laser was realized to meet rough requirements posed by industrial applications. This slim design is the ideal replacement of traditional gas and ion UV lasers.