gebhart/patrepeval huggingface dataset:
P2‐403: A randomized, multicenter, placebo controlled trial of memantine for behavioral variant FTD and semantic variant PPA (2012)

Frontotemporal dementia (FTD) is a common form of dementia in younger individuals that encompasses three clinical syndromes, a behavioral variant FTD (bvFTD) and two primary progressive aphasias (PPA). There are no FDA-approved treatments for FTD. Our previous work has shown that 56% of bvFTD patients take either acetylcholinesterase inhibitors (AChI) or memantine without evidence from randomized placebo controlled trials to support their use. Based on the results of a 26 week open-label study of memantine for FTD that demonstrated a transient improvement of neuropsychiatric inventory (NPI) scores in bvFTD and semantic variant PPA (svPPA) patients, we tested the hypothesis that memantine can slow the rate of behavioral decline in these FTD subtypes. Secondary objectives were to assess safety and tolerability of memantine in FTD, and whether it could stabilize cognitive decline or the emergence of parkinsonism in FTD. Nine US academic dementia centers participated in the study. Participants met Neary (1998) criteria for bvFTD or svPPA, had brain atrophy on CT or MRI consistent with FTD, a MMSE ≥ 15 and aged 40-80. Use of AChI, memantine and antipsychotics within 4 weeks of randomization was prohibited. Individuals with other forms of PPA or severe motor impairments were excluded. Individuals were randomized 1:1 to 20 mg memantine daily: placebo for 26 weeks. The primary endpoints were the change in total NPI score and Clinical Global Impression of Change scores over 26 weeks of treatment. Secondary outcome measures included: CDR-SB (FTD version), functional activities questionnaire, a FTD neuropsychology battery, Texas Functional Living Scale, UPDRS, and the number of subjects taking antipsychotic medications. 96 subjects were screened, 80 were randomized, 5 discontinued and 75 are projected to complete all visits at study close in 3/2012. There were 61 bvFTD and 20 svPPA patients enrolled. Mean age was 63.9 ± 7.5 years, MMSE 25.4 ± 4.4, CDR-total 1.9 ± 0.6, CDR-SB 5.8 ± 2.9, NPI- total 21.5 ± 17.4, CGI-severity 4.3 ± 0.8 at baseline. Results of the primary and secondary outcome analyses will be presented. Multicenter, randomized, placebo controlled trials are feasible in FTD. This study will provide Class I evidence on the use of memantine to treat FTD.
Nonempirical Apparent Permeability of Shale (2014)

Summary Physics of fluid flow in shale reservoirs cannot be predicted from standard flow or mass-transfer models because of the presence of nanopores, ranging in size from one to hundreds of nanometers, in shales. Conventional continuum-flow equations, such as Darcy's law, greatly underestimate the fluid-flow rate when applied to nanopore-bearing shale reservoirs. As a result of the existence of nanopores in shales, the molecular mean free path becomes comparable with the characteristic geometric scale, and we hypothesize that under this condition, Knudsen diffusion, in addition to correction for the slip boundary condition, becomes the dominant mechanism. Recently, a few models have been developed that use various empirical parameters to account for these modifications (Javadpour 2009; Civan 2010; Darabi et al. 2012). This paper aims to provide a different approach to modeling apparent permeability in shale reservoirs. The proposed model is analytical, free of any empirical coefficients, and has been derived without invoking the assumption of slip flow at the pore wall. Our model of apparent permeability represented by a single analytical equation, depends only on pore size, pore geometry, temperature, gas properties, and average reservoir pressure. The proposed model is valid for Knudsen numbers less than unity and it stands up under the complete operating conditions of a shale reservoir. Our model reasonably predicts results as reported by other models. Finally, the model shows that pore-surface roughness and mineralogy have a negligible influence on gas-flow rate, whereas pore geometry and pore size play a significant role in the proportion of diffusion in total flow rate. Our study shows that a combination of Darcy flow and Knudsen flow—ignoring the Klinkenberg effect—can describe gas flow for a range of Knudsen flow applicable to a shale-gas system.
Fusing the real and the virtual: A depth-camera based approach to Mixed Reality (2011)

The seamless integration of the real and the virtual content is the ultimate yet unreached goal of Mixed Reality applications. Among others it requires mutual blocking and lighting between real and virtual objects. In this paper we present our approach of applying a low-cost depth camera, such as Kinect, allowing for an easy acquisition of depth images. However, as the quality of the raw input data is insufficient for this purpose, we apply a series of filter and optimization operations. This allows us to realize mutual real-time lighting and rigid interaction in a dynamic environment. Our approach produces an acceptable quality of images of low-frequency scenes at interactive frame rates on an off-the-shelf desktop computer.
公众文本之情感词典研究进展 (2014)

Sentiment analysis for big social media data could not only detect and track public opinions about so-cial events, political movements, company strategies and decisions in real time, but also understand users emotions which are expressed through reviews, blogs, microblogs/tweets and other text. In this article, we rst present the progress of generating sentiment lexicons in text with subjective words from the writers perspective, including the thesaurus-based and corpora-based methods and typical applications. Then, the progress of generating social emotion lexicons by the emotional responses of readers from the readers perspective is reviewed, which includes the data sources, word-level and topic-level models.
NovelSCN9AMutations Underlying Extreme Pain Phenotypes: Unexpected Electrophysiological and Clinical Phenotype Correlations (2015)

The importance of NaV1.7 (encoded by SCN9A) in the regulation of pain sensing is exemplified by the heterogeneity of clinical phenotypes associated with its mutation. Gain-of-function mutations are typically pain-causing and have been associated with inherited erythromelalgia (IEM) and paroxysmal extreme pain disorder (PEPD). IEM is usually caused by enhanced NaV1.7 channel activation, whereas mutations that alter steady-state fast inactivation often lead to PEPD. In contrast, nonfunctional mutations in SCN9A are known to underlie congenital insensitivity to pain (CIP). Although well documented, the correlation between SCN9A genotypes and clinical phenotypes is still unclear. Here we report three families with novel SCN9A mutations. In a multiaffected dominant family with IEM, we found the heterozygous change L245 V. Electrophysiological characterization showed that this mutation did not affect channel activation but instead resulted in incomplete fast inactivation and a small hyperpolarizing shift in steady-state slow inactivation, characteristics more commonly associated with PEPD. In two compound heterozygous CIP patients, we found mutations that still retained functionality of the channels, with two C-terminal mutations (W1775R and L1831X) exhibiting a depolarizing shift in channel activation. Two mutations (A1236E and L1831X) resulted in a hyperpolarizing shift in steady-state fast inactivation. To our knowledge, these are the first descriptions of mutations with some retained channel function causing CIP. This study emphasizes the complex genotype-phenotype correlations that exist for SCN9A and highlights the C-terminal cytoplasmic region of NaV1.7 as a critical region for channel function, potentially facilitating analgesic drug development studies.
Tunable Cavity Optomechanics with Ultracold Atoms (2010)

We present an atom-chip-based realization of quantum cavity optomechanics with cold atoms localized within a Fabry-Perot cavity. Effective subwavelength positioning of the atomic ensemble allows for tuning the linear and quadratic optomechanical coupling parameters, varying the sensitivity to the displacement and strain of a compressible gaseous medium. We observe effects of such tuning on cavity optical nonlinearity and optomechanical frequency shifts, providing their first characterization in the quadratic-coupling regime.
Lateral Alveolar Ridge Expansion in the Anterior Maxilla Using Piezoelectric Surgery for Immediate Implant Placement (2016)

The results from this study support the efficacy and safety of ridge expansion using piezoelectric surgery for implant insertion in the anterior maxilla. The modest net gain in bone width suggests that additional hard and soft tissue augmentation may be necessary, especially in the esthetic zone. ISQ values suggest a minimum healing time of 3 months before loading the implants that have been inserted using this ridge-splitting protocol.
Modeling Routing Overhead of Reactive Protocols at Link Layer and Network Layer in Wireless Multihop Networks (2014)

To keep information recent between two nodes, two types of link sensing feed-back mechanisms are used: link layer (LL) and network layer (NL). In this paper, we model and evaluate these link sensing mechanisms in three widely used reactive routing protocols: ad hoc on-demand distance vector (AODV), dynamic source routing (DSR), and dynamic MANET on-demand (DYMO). Total cost paid by a routing protocol is the sum of cost paid in the form of energy consumed (in terms of packet reception/transmission) and time spent (in terms of processing route information). Routing operations are divided into two phases: route discovery (RD) and route maintenance (RM). These protocols majorly focus on broadcast cost optimization performed by expanding ring search (ERS) algorithm to control blind flooding. Hence, our model relates link sensing mechanisms in RD and RM for the selected routing protocols to compute consumed energy and processing time. The proposed framework is evaluated via NS-2, where the selected protocols are tested with different nodes' mobilities and densities.
A Continuous Culture System for Assessing Microbial Activities in the Piezosphere (2015)

Continuous culture under elevated pressures is an important technique for expanding the exploration of microbial growth and survival in extreme environments associated with the deep biosphere. Here we present a benchtop stirred continuous culture bioreactor capable of withstanding temperatures ranging from 25 to 120°C and pressures as high as 69 MPa. The system is configured to allow the employment of media enriched in dissolved gases, under oxic or anoxic conditions, while permitting periodic sampling of the incubated organisms with minimal physical/chemical disturbance inside the reactor. In a pilot experiment, the fermentative growth of the thermopiezophilic bacterium Marinitoga piezophila was investigated continuously for 382 h at 65°C and at pressures ranging from 0.1 to 40 MPa while the medium flow rate was varied from 2 to 0.025 ml/min. The enhanced growth observed at 30 and 40 MPa and 0.025 ml/min supports the pressure preferences of M. piezophila when grown fermentatively. This assay successfully demonstrates the capabilities of the bioreactor for continuous culturing at a variety of dilution rates, pressures, and temperatures. We anticipate that this technology will accelerate our understanding of the physiological and metabolic status of microorganisms under temperature, pressure, and energy regimes resembling those of the Earth's piezosphere.
Novel Marine and Microbial Natural Product Inhibitors of Vacuolar ATPase (2003)

Vacuolar-ATPase (V-ATPase) has been proposed as a drug target in osteoporosis due to its involvement in bone resorption, and as a target in cancer due to potential involvement in tumor invasion and metastasis. The classical selective inhibitors of V-ATPase are microbial macrolides of the bafilomycin and concanamycin class. These inhibitors have proven to be too toxic for therapeutic use, however recent structure-activity studies on bafilomycins, and the isolation of novel macrolide structures from marine sources, have provided new avenues for development of potentially less toxic V-ATPase inhibitors. The novel salicylihalamide and lobatamide series of compounds were predicted to share a common mechanism of action based on the patterns of cytotoxicity produced in the NCI 60-cell cancer screen. They have subsequently been shown to selectively interact with mammalian V-ATPases, but not with fungal V-ATPases. With the recent achievement of total syntheses of salicylihalamide, lobatamide, and related compounds, the elaboration of congeners with specificity for particular enzyme isoforms may provide drug candidates which are less toxic. This review summarizes recent advances in V-ATPase inhibition and the prospects for further progress.
Evaluation of fibular head transposition, lateral fabellar suture, and conservative treatment of cranial cruciate ligament rupture in large dogs: a retrospective study (1996)

Sixty-one large dogs (weighing 22.7 kg or more) with cranial cruciate ligament ruptures (CCLRs) were treated with either fibular head transpositions (FHTs; n = 22 stifles), lateral fabellar sutures (LFSs; n = 39 stifles), or conservatively (CT; n = 11 stifles) with rest and aspirin. Based on owner evaluation, dogs treated with FHTs or CT did not perform as well as dogs treated with LFSs (p less than 0.05). There was no difference in owner evaluation scores for the dogs treated with FHTs or CT. Thirty dogs were reevaluated by investigators. No differences between treatment groups regarding age, sex, or time until diagnosis were noted. No differences in scores for lameness, stifle instability, or forceplate analysis among the treatment groups were observed. Degenerative joint disease progressed or remained severe regardless of treatment, based upon radiographic evidence.
SARS-CoV-2: Novel Therapeutic Approaches for Diagnosis and Treatment (2022)

ADVERTISEMENT RETURN TO ISSUEPREVPatent HighlightNEXTSARS-CoV-2: Novel Therapeutic Approaches for Diagnosis and TreatmentRobert B. Kargbo*Robert B. KargboUsona Institute, 277 Granada Drive, San Luis Obispo, California 93401-7337, United States*[email protected]More by Robert B. Kargbohttps://orcid.org/0000-0002-5539-6343Cite this: ACS Med. Chem. Lett. 2022, 13, 7, 999–1001Publication Date (Web):June 6, 2022Publication History Received15 May 2022Published online6 June 2022Published inissue 14 July 2022https://pubs.acs.org/doi/10.1021/acsmedchemlett.2c00231https://doi.org/10.1021/acsmedchemlett.2c00231editorialACS PublicationsCopyright © Published 2022 by American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1250Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (742 KB) Get e-AlertscloseSUBJECTS:Cancer therapy,Genetics,Peptides and proteins,SARS-CoV-2,Small molecules Get e-Alerts
Improving functional density using run-time circuit reconfiguration [FPGAs] (1998)

The ability to provide flexibility and allow fine-grain circuit specialization make field programmable gate arrays (FPGA's) ideal candidates for computing elements within application-specific architectures. The benefits of gate-level specialization and reconfigurability can be extended by reconfiguring circuit resources at run-time. This technique, termed run-time reconfiguration (RTR), allows the exploitation of dynamic conditions or temporal locality within application-specific problems. For several applications, this technique has been shown to reduce the hardware resources required for computation. The use of this technique on conventional FPGA's, however, requires additional time for circuit reconfiguration. A functional density metric is introduced that balances the advantages of RTR against its associated reconfiguration costs. This metric is used to justify run-time reconfiguration against other more conventional approaches. Several run-time reconfigured applications are presented and analyzed using this approach.
Evaluation of baseline BRAF V600E mutation in circulating tumor DNA and efficacy response from the BEACON study. (2022)

162 Background: In the randomized phase 3 BEACON study, encorafenib + binimetinib + cetuximab (triplet) and encorafenib + cetuximab (doublet) regimens improved overall survival (OS) and objective response rate (ORR) versus standard of care (control) in patients (pts) with previously treated BRAF V600E-mutant metastatic colorectal cancer. To identify whether detection of a BRAF V600E mutation in baseline circulating tumor DNA (ctDNA) correlated with response, we evaluated the status and allele frequency of BRAF V600E compared with clinical outcomes. Methods: Plasma samples were collected at Cycle 1 Day 1 and end of treatment for ctDNA analysis and analyzed using GuardantOMNI. Variant allele frequency (VAF) of BRAF V600E was grouped into high (&gt; median) and low (≤median) categories. Low VAF samples included those where BRAF V600E mutation was not detected or no ctDNA was detected. ORR, based on blinded independent central review, and OS were compared between treatment arms according to VAF levels. ORR comparisons used Chi-square test and logistic regression. OS was summarized using the Kaplan-Meier method. HRs and 95% CIs were estimated using a Cox model. Additional correlation analyses between BRAF V600E status in baseline tumor tissue, as well as clonality, will be presented. Results: Baseline plasma samples were analyzed from 544 of 631 pts in the ctDNA analysis: 88.3% (196/222) in the triplet arm, 86.6% (187/216) in the doublet arm, and 83.4% (161/193) in the control arm. BRAF V600E mutations were detected in 90.4% (492/544) of pts (90.3% [177/196] triplet, 90.4% [169/187] doublet, and 90.7% [146/161] control). Pts with BRAF V600E mutations with high VAF had significantly ( P≤0.0001) increased ORR (95% CI) in the triplet and doublet arms (27.3% [19.5–36.8] and 15.9% [9.7–25.0], respectively) compared with control (0% [0.0–4.3]). Similar response trends were observed in pts with BRAF V600E mutations with low VAF (triplet: 28.9% [20.8–38.9]; doublet: 25.3% [17.7–34.6]; control: 5.3% [2.1–12.8]). OS decreased in BRAF V600E pts with high VAF (median OS [95% CI]: triplet 7.2 [6.0–8.0] months, n = 99; doublet 5.4 [4.4–6.1] months, n = 88; control 4.2 [3.4–4.8] months, n = 85) compared with pts with low VAF (triplet 14.8 [10.2–19.8] months, n = 97; doublet 14.8 [11.7–23.0] months, n = 99; control 9.3 [7.5–11.3] months, n = 76). Conclusions: ctDNA analyses showed the majority of pts in BEACON analyzed at baseline had a detectable BRAF V600E mutation. Increased response rates were observed in pts treated with triplet or doublet therapy compared with control, independent of VAF. Pts with a higher VAF for BRAF V600E may have a worse prognosis. Clinical trial information: NCT04607421.
Thermo-Optic Microsensor With Double Core Optical Fiber For Medical Applications (1988)

Microsensor with double core optical fiber for temperature measurement is presented herein. Double core optical fiber is used in order to diminish size of a probe in which there is a semiconductor sample glued to the end of the fiber. During doubled passage of light through the semiconductor sample, the amount of absorbed light changes due to temperature - caused shifts in the absorption edge.
Enhancement of Alkene Epoxidation Activity of Titanosilicates by Gas‐Phase Ammonia Modification (2012)

Abstract Novel ammonia‐treated titanosilicates have been prepared by heating the samples of Ti‐MWW, TS‐1 and Ti‐Beta under pure ammonia gas flow at 673 K for a period of time. The ammonia modification improved their catalytic performance in liquid‐phase oxidations. Especially, the catalytic activities of ammonified Ti‐MWW, N‐Ti‐MWW, were enhanced greatly in the epoxidation of 1‐hexene with H 2 O 2 . The reason that the ammonia treatment played such an important role in post‐modification of titanosilicate was investigated in details. In comparison to the parent Ti‐MWW catalyst, N‐Ti‐MMW was more robust and produced less coke in oxidation reactions.
Formation of SXT Tandem Arrays and SXT-R391 Hybrids (2004)

SXT is an integrative and conjugative element (ICE) isolated from Vibrio cholerae. This approximately 100-kb ICE encodes resistance to multiple antibiotics and integrates site specifically into the chromosome. SXT excises from the chromosome to form a circular but nonreplicative extrachromosomal molecule that is required for its transfer. Here we found that a significant fraction of freshly isolated SXT exconjugants contained tandem SXT arrays. There was heterogeneity in the size of the SXT arrays detected in single exconjugant colonies. Some arrays consisted of more than five SXTs arranged in tandem. These extended arrays were unstable and did not persist during serial passages. The mechanism accounting for the generation of SXT arrays is unknown; however, array formation was not dependent upon recA and appeared to depend on conjugative transfer. While such arrays did not alter the transfer frequency of wild-type SXT, they partially complemented the transfer deficiency of a Deltaxis SXT mutant, which is ordinarily unable to generate the extrachromosomal intermediate required for SXT transfer. Exconjugants derived from donor strains that harbored tandem arrays of SXT and R391, an SXT-related element, contained functional hybrid elements that arose from recA-independent recombination between the two ICEs. Thus, arrays of SXT-related elements promote the creation of novel ICEs.
Polymer Thick Films: What Are They, How Are They Used and Where? (1986)

The paper introduces the concept of Polymer Thick Film for low temperature resistor and conductor printing. It describes the materials and their characteristics and outlines some of the applications for which PTF can be and is being used.