gebhart/patrepeval huggingface dataset:
Phase Locking Thousands of Laser (2011)

Experimental realization for phase locking several thousands of lasers arranged in a variety of 2D geometries is presented. Coupling ranges and sign are easily controlled giving rise to a variety of intriguing phase structures.
ChemInform Abstract: Evolution of Enzymes and Pathways for the Biosynthesis of Cofactors (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Linkage of Hereditary Distal Myopathy with Desmin Accumulation to 2q (2000)

We are investigating the genetics of a large family with an autosomal dominant form of hereditary distal myopathy. This slowly progressive myopathy begins during early adulthood in the distal leg muscles, producing a gait disturbance. Cardiomyopathy is also present in most affected family members, manifesting itself as conduction block or congestive heart failure. Histologically, an accumulation of the protein, desmin, occurs in the subsarcolemmal spaces of myofibers. We have performed linkage analyses of this family, and have mapped the location of the gene causing the myopathy to human chromosome 2q33. The gene is within a 17-cM segment of chromosome 2q bounded by the DNA markers D2S2248 and D2S401. The best candidate gene for this myopathy is desmin.
Correlation between losses of IGH or its segments and deletions of 13q14 in t(11;14) (q13;q32) multiple myeloma (2009)

Multiple myeloma (MM) is a malignancy of the plasma cells (PCs) characterized by a wide variety of genetic and chromosomal abnormalities. In recent years, major attention was drawn to the significance of chromosomal aberrations involving chromosome arm 13q and the IGH region on chromosome band 14q32 as a prognostic indicator in MM. In this study we applied a combined cell morphology and FISH method for the analysis of coexistence of t(11;14)(q13;q32) with deletions of the long arm of chromosome 13 (Delta13) in PCs from 51 MM patients using several probes for the 13q14, 11q13, and IGH regions. We found 15 different variants of the t(11;14) that are the consequence of different 11q13 breakpoints and various deletions of Variable (del IGH Var) or Constant (del IGH Const) IGH segments and also duplications and losses of the IGH gene on the normal nontranslocated chromosome 14 as well as IGH/Cyclin D1 (CCND1) fusion on der(14) and CCND1/IGH fusions on der(11). A strong association between Delta13 and specific variants of t(11;14) was found: variants with deletion of the IGH gene or its segments were found only in MM cases with deleted chromosome 13, while the common translocation t(11;14) was found only in the MM cases with normal chromosome arm 13q. In contrast, we did not find any association between Delta13 and deletions of the IGH gene or its segments in the MM patients with t(4;14)(p16;q32).
Los desafíos de las nuevas caras de la globalización / Challenges of the Globalization’s New Faces (2019)

El mundo esta experimentando tiempos de cambio en los que las tecnologias, la globalizacion y una transferencia historica del poder economico de Occidente a Oriente y el Sur estan creando grandes cambios que desafian nuestras ideas y politicas en el desarrollo economico y social. El final de la era de auge de los altos precios de las materias primas ha terminado y sera seguido por un periodo de crecimiento lento y una posible perdida de las conquistas sociales de los ultimos anos, lo que tendra consecuencias politicas y economicas graves para el sector mas pobre de nuestras sociedades. Se requiere un nuevo conjunto de politicas economicas para hacer frente a estos desafios complejos. / The world is going through times of changes where technologies, globalization and a historic transference of the economic power from West to East and South, are creating huge changes which challenge our ideas and policies in the economic and social development. The end of the boom of raw materials high prices has finished and it will be followed by a period of slow growing and a possible loss of social achievements of the last years. All this will have serious political and economic consequences. For the poorest sector of our societies a new group of economic policies are required to face these complex challenges.
Development of underwater WPT system independent of salinity (2014)

We are aiming at construction of a WPT system which can keep high power transfer efficiency in water irrespective of dissolved medium by relying on our studies on the removal of dielectric effect to the system. The influence of water appears in two forms, the resonant frequency and the power transfer efficiency. The former is induced by the high dielectric constant, whereas the latter is the result of high conductivity of ionized materials including water itself. We have clarified that the resonant frequency is made quite stable and dielectric loss induced from the imaginary part of dielectric materials is also reduced appreciably by use of magnetically coupled resonators. Though it is not known whether the power transfer loss arising from ionized particles is also reduced by the same resonator systems, we have tried on the line of the same concept, investigating unloaded Q value of the magnetically coupled resonator systems under various conditions. As a result, when we fabricate the transmitting and receiving resonator of 2-layered coil resonator using resonator diameter of 30cm with litz wire, and the resonant frequency of 100 kHz, the efficiency approximately 88% is obtained at the same salinity with seawater for the resonator distance of 15cm.
Combination of Multiplex PCRs for Staphylococcal Cassette Chromosome mec Type Assignment: Rapid Identification System for mec , ccr , and MajorDifferences in Junkyard Regions (2006)

Staphylococcal cassette chromosome mec (SCCmec) typing, in combination with genotyping of the Staphylococcus aureus chromosome, has become essential for defining methicillin-resistant S. aureus (MRSA) clones in epidemiological studies. We have developed a convenient system for SCCmec type assignment. The system consists of six multiplex PCRs (M-PCRs) for identifying the ccr gene complex (ccr), the mec gene complex (mec), and specific structures in the junkyard (J) regions: M-PCR with primer set 1 (M-PCR 1) identified five types of ccr genes; M-PCR 2 identified class A to class C mec; M-PCRs 3 and 4 identified specific open reading frames in the J1 regions of type I and IV and of type II, III, and V SCCmec elements, respectively; M-PCR 5 identified the transposons Tn554 and PsiTn554 integrated into the J2 regions of type II and III SCCmec elements; and M-PCR 6 identified plasmids pT181 and pUB110 integrated into J3 regions. The system was validated with 99 MRSA strains carrying SCCmec elements of different types. The SCCmec types of 93 out of the 99 MRSA strains could be assigned. The SCCmec type assignments were identical to those made with a PCR system that uses numerous primer pairs to identify genes or gene alleles. Our system of six M-PCRs is thus a convenient and reliable method for typing SCCmec elements.
A Case of Slowly Progressive Type 1 Diabetes with Insulin Independence Maintained for 10 Years with α-glucosidase Inhibitor Monotherapy (2012)

Slowly Progressive Type 1 Diabetes (SPT1D) is characterized by the absence of insulin dependence at the onset of diabetes and persistent detection of islet cell autoantibodies. These patients with high titers of glutamic acid decarboxylase autoantibodies (GADA) are known to progress to insulin dependence within several years. Low-dose insulin injections have been reported to prevent or delay the decline of insulin secretion in SPT1D patients. We experienced the case of an SPT1D patient with preserved endogenous insulin secretion and good glycemic control achieved with α-glucosidase inhibitor (α-GI) treatment alone for 10 years despite having continuously elevated GADA titers. The details of this case suggest that α-GI treatment might have preventive effects on SPT1D progression.
The dark side of ZNF217, a key regulator of tumorigenesis with powerful biomarker value (2015)

The recently described oncogene ZNF217 belongs to a chromosomal region that is frequently amplified in human cancers. Recent findings have revealed that alternative mechanisms such as epigenetic regulation also govern the expression of the encoded ZNF217 protein. Newly discovered molecular functions of ZNF217 indicate that it orchestrates complex intracellular circuits as a new key regulator of tumorigenesis. In this review, we focus on recent research on ZNF217-driven molecular functions in human cancers, revisiting major hallmarks of cancer and highlighting the downstream molecular targets and signaling pathways of ZNF217. We also discuss the exciting translational medicine investigating ZNF217 expression levels as a new powerful biomarker, and ZNF217 as a candidate target for future anti-cancer therapies.
Electric-current transmission through the contact of two metals (1995)

We study the current transmission through a nonideal interface between two different metals. The exact equations relating the electron distribution functions in the bulk of metals are obtained. These equations take into account the specular scattering of electrons from the contacting surface as well as the diffusive scattering from defects at the interface. A specific resistance of contact is calculated. The approach makes it possible to take into account the nonideality of the interface in a rigorous way.
Bubble driven catalytic micromotors (2014)

This year (2014) we celebrate a decade anniversary of catalytic micromotors, in which they have come to represent one of the important technical advances, having shown promise in many important functions in biomedical and engineering fields such as sensing, detection, drug delivery, oil spill cleanup, etc. Catalytic nano-/ micromotors are structures that convert chemical energy present in the surrounding aqueous environment into mechanical work through a catalytic reaction induced by an asymmetrically placed catalyst. This dissertation focuses on the fundamental study of the motion mechanics of catalytic motors.
Diffusiophoresis is the motion of motors due to diffusion of reaction entities, such as the fuel or by-products of the catalytic reaction. Small Janus catalytic motors i.e., spherical microbeads half coated with catalyst metal, utilize the diffusiophoresis mechanism. Introduction of a hydrophobic front surface in Janus catalytic has been observed to make them appreciably faster due to changes in reaction kinetics.
The bubble propulsion mechanism is observed when the bubbles formed on the catalyst surface eject or burst. The motion of bubbles provides an opposing thrust to the motor. We have studied the motion of bubble propelled big Janus motors using a fast CCD camera. The formation of bubbles depends closely on the nucleation energy, which also is related to surface curvature. It is predicted that bubbles are easier to nucleate on a concave shaped surface than on
a convex shaped surface. Thus, bubble propulsion can be easily seen in concave motors. The predictions were confirmed with nanoshell catalytic motors with catalyst coated inside the shell. Similarly, if the catalyst is coated in the inner surface of a tube, a tubular motor can be produced. We used graphene oxide nanosheets (GO) as templates and the stress effect in the multilayer of metal thin films to create microtubes.
Finally, collective motion has been observed with 5-μm diameter Janus motors. These motors are too small for bubble propulsion to occur, but collectively they produce bubble and perform a synchronized motion. The collective motion is a result of Marangoni effect.
Selective staining of Brønsted acidity in zeolite ZSM-5-based catalyst extrudates using thiophene as a probe (2014)

Optical absorption and confocal fluorescence micro-spectroscopy were applied to investigate Brønsted acidity in millimetre-sized extrudates of Na(H)-ZSM-5 and SiO2 with varying ZSM-5 content. Partially (residual Na present) and fully proton-exchanged extrudates were employed, using thiophene oligomerization as a probe reaction. Time-resolved in situ optical absorption spectra and time dependent DFT calculations revealed several initial reaction pathways during the oligomerization reaction. In particular, it was found that protonated thiophene monomers reacted by either oligomerization (via reaction with un-reacted thiophene monomers) or ring-opening, depending on the Brønsted acid site density in each sample. Moreover, fully-exchanged extrudates not only have significantly higher reactivity than partially-exchanged samples, but they also favour the formation of ring-opening products, that are not formed on the partially-exchanged samples. Confocal fluorescence microscopy was employed to visualise non-invasively in 3D, the heterogeneity and homogeneity of thiophene oligomers on partially- and fully-exchanged extrudates, respectively. Furthermore, it was observed that extrudates with high binder content produce a higher relative amount of conjugated species, related with a higher quantity of available monomer in the binder, which is able to react further with intermediates adsorbed on active sites. Moreover, these conjugated species appear to form near the external surface of ZSM-5 crystals/agglomerates.
Glutaraldehyde crosslinking of collagen substrates inhibits degradation in skin substitutes grafted to athymic mice (1997)

Collagen-based implants have been described as vehicles for transplantation of cultured skin cells for treatment of burn wounds. To optimize vascularization and repair of connective tissue, collagen solubility and glutaraldehyde crosslinking were evaluated. Cultured skin substitutes consisted of human keratinocytes and fibroblasts attached to collagen-glycosaminoglycan substrates that were prepared from acid-insoluble, or partially soluble collagen. Substrates were crosslinked with 0% or 0.25% glutaraldehyde, populated with cells, and grafted to full-thickness wounds on athymic mice (n = 6/condition). After 6 weeks, the wound area was measured by planimetry, and healed wounds were scored by histochemistry for immunoreactivity to HLA-ABC and bovine collagen. Data analysis shows that crosslinking of collagen implants with glutaraldehyde is associated (p < 0.001) with detection of the implant. No association was found between solubility of bovine collagen and immunodetection. Epidermis of all wounds was positive for HLA-ABC, and no differences in wound areas were found. These results suggest that glutaraldehyde crosslinking of collagen implants decreases the rate of biodegradation. Delayed degradation of crosslinked collagen may result clinically in reduced engraftment of skin substitutes.
The stanniocalcin family of proteins (2006)

Stannniocalcin (STC) is a polypeptide hormone that was originally identified in bony fishes as a systemic regulator of mineral metabolism, and is best known for its regulatory effects on calcium/phosphate transport by the gills, gut and kidneys. The mammalian homolog to fish STC was discovered in 1995 and has resulted in progressively growing interest ever since as to its possible role in humans. Moreover, new discoveries in the mammalian STC field are resulting in significant reappraisals as to its role in fishes. Perhaps the most significant of these has been the discovery of a second gene encoding stanniocalcin-related protein, or STC-2, first in mammals and subsequently in fish. This review covers the comparative endocrinology of the STCs in fishes and mammals from the perspectives of structure, function and regulation. It then delves into some of the newer aspects of STC-1/STC-2 biology that have been uncovered using both classical and transgenic approaches. Of these, one of the most intriguing discoveries relates to the receptor-mediated sequestration of STC by target cell organelles. The functions of other newly discovered mammalian and fish STC variants are also discussed, as is the recent discovery of STC-related homologs in invertebrates. Based on our current state of knowledge, it is apparent that STC has an ancient lineage and that the STC family of proteins is proving to have significant roles in metabolism, reproduction and development.
Crystal Structure of the Human SUV39H1 Chromodomain and Its Recognition of Histone H3K9me2/3 (2012)

SUV39H1, the first identified histone lysine methyltransferase in human, is involved in chromatin modification and gene regulation. SUV39H1 contains a chromodomain in its N-terminus, which potentially plays a role in methyl-lysine recognition and SUV39H1 targeting. In this study, the structure of the chromodomain of human SUV39H1 was determined by X-ray crystallography. The SUV39H1 chromodomain displays a generally conserved structure fold compared with other solved chromodomains. However, different from other chromodomains, the SUV39H1 chromodomain possesses a much longer helix at its C-terminus. Furthermore, the SUV39H1 chromodomain was shown to recognize histone H3K9me2/3 specifically.
Survey Of Lossless Image Coding Techniques (1989)

Many image transmission/storage applications requiring some form of data compression additionally require that the decoded image be an exact replica of the original. Lossless image coding algorithms meet this requirement by generating a decoded image that is numerically identical to the original. Several lossless coding techniques are modifications of well-known lossy schemes, whereas others are new. Traditional Markov-based models and newer arithmetic coding techniques are applied to predictive coding, bit plane processing, and lossy plus residual coding. Generally speaking, the compression ratio offered by these techniques are in the area of 1.6:1 to 3:1 for 8-bit pictorial images. Compression ratios for 12-bit radiological images approach 3:1, as these images have less detailed structure, and hence, their higher pel correlation leads to a greater removal of image redundancy.
Passive prosthetic ankle-foot mechanism for automatic adaptation to sloped surfaces (2014)

This article describes the development of a prototype prosthetic ankle-foot system that passively adapts to surface slopes on each step of walking. Engineering analyses were performed to design the cam clutch and clutch engagement and disengagement mechanism. The prototype was tested by a veteran with a unilateral transtibial amputation. Kinematic and kinetic data were recorded while the subject walked on a treadmill at slopes ranging from -10 degrees to +10 degrees. After each slope condition, the subject rated his level of exertion and socket comfort. The subject reported increased comfort and reduced exertion for downhill slopes when using the prototype compared with his usual prosthesis. The subject also expressed that when walking downhill on the prototype, it was the most comfortable he has ever been in a prosthesis. The prosthetic ankle torque-angle relationship shifted toward dorsiflexion for uphill and toward plantar flexion for downhill slopes when using the prototype, indicating slope adaptation, but this effect did not occur when the subject walked with his usual prosthesis. The prototype also demonstrated late-stance plantar flexion, suggesting the potential for storing and returning more energy than standard lower-limb prostheses.
Two‐Phase Hydroformylation of Higher Olefins Using Randomly Methylated α‐Cyclodextrin as Mass Transfer Promoter: A Smart Solution for Preserving the Intrinsic Properties of the Rhodium/Trisulfonated Triphenylphosphine Catalytic System (2005)

Abstract The two‐phase hydroformylation of higher olefins with the rhodium/trisulfonated triphenylphosphine catalytic system in the presence of various chemically modified α‐cyclodextrins has been investigated. These cyclodextrins allowed us to increase greatly the reaction rate and the chemoselectivity of the reaction but, contrary to what has been observed previously with the chemically modified β‐cyclodextrins, the linear to branched aldehydes ratio was not affected by the presence of α‐cyclodextrin derivatives. Indeed, the latter was found to be similar to that obtained without any mass transfer promoter, suggesting that the catalytic species are stable in the presence of α‐cyclodextrin derivatives.
Highly Efficient Defluoridation of Water through Reusable poly(aniline-co- o -aminophenol) Copolymer Modified Electrode Using Electrochemical Quartz Crystal Microbalance (2021)

Although the World Health Organization (WHO) recommends a limit of 1.5 mg l −1 fluoride ions in drinking water, this is not satisfied in many parts of the world. When this limit is exceeded, the electrochemically switched ion-exchange (ESIX) technique (mainly based on conductive polymers) has been identified as a promising method for removing the excess fluoride ions. The present study aimed to develop an efficient method based on the ESIX technique by using poly(aniline-co- o -aminophenol) copolymer to extract fluoride ions. Electrochemical quartz crystal microbalance (EQCM) and acoustic admittance data were utilized to assay the synthetic efficiency of copolymer deposition, and to evaluate the dependence of the defluoridation process on the proportions of the monomers in the copolymer matrix and on film thickness. The resulting films were characterised by Fourier transform infrared spectroscopy (FTIR) and scanning electrochemical microscopy (SEM) techniques. For optimized co-monomer ratio in the feedstock, poly(aniline-co- o -aminophenol) at an applied potential of 0.30 V showed excellent performance for fluoride removal from water at pH 6.6, to the extent of 20 (mg F − ) (g polymer) −1 . Comparison of the performance of ESIX using poly(aniline-co- o -aminophenol) with that of other techniques and materials reveal that it has significant potential for water defluoridation.
Metal‐Nitrogen‐Carbon Cluster‐Decorated Titanium Carbide is a Durable and Inexpensive Oxygen Reduction Reaction Electrocatalyst (2021)

Abstract Invited for this month′s cover are the groups of Prof. Vijay Ramani and Prof. Rohan Mishra at Washington University in St. Louis and their collaborators at Oak Ridge National Laboratory. The Full Paper itself is available at 10.1002/cssc.202101341 .
Biologie moleculaire de l'angiotensinogene humain : comparaison avec deux serpines : l'alpha 1-antitrypsine et l'antithrombine 3 (1989)

L'angiotensinogene est le seul substrat connu de la renine. L'analyse de l'adnc et de la sequence en acides amines de l'angiotensinogene met en evidence des analogies significatives avec les proteines appartenant a la famille des inhibiteurs des serines-proteases (alpha antitrypsine, antithrombine 3). Nous decrivons ici, pour la premiere fois, le clonage et la caracterisation du gene de l'angiotensinogene humain. Ce gene contient 5 exons et 4 introns. Par le nombre et la taille des exons ainsi que par la position des jonctions introns-exons, nous avons pu montrer que l'organisation du gene de l'angiotensinogene humain etait tres proche de celles des genes de l'angiotensinogene de rat, de l'alpha antitrypsine et de l'antithrombine 3. La region 5 flanquante du gene de l'angiotensinogene humain a ete soigneusement analysee. Dans cette region, de courtes sequences nucleotidiques presentant un degre d'homologie suffisant avec des sequences decrites dans la litterature comme etant des sites d'interaction adn-recepteurs ont ete localisees pour les recepteurs aux glucocorticoides, aux strogenes et aux hormones thyroidiennes. Par ailleurs, les arnm codant pour les trois serpines etudiees ont ete localises par hybridation in situ dans du foie humain normal. La localisation chromosomique du gene de l'angiotensinogene humain a ete effectuee et l'etude de 7 variants de l'antithrombine 3 associee a une deficience qualitative de cette proteine a ete effectuee