gebhart/patrepeval huggingface dataset:
julia v0.5.0-rc2 (2016)

We have been fixing 0.5-critical bugs since the last release candidate, and are now releasing 0.5.0-rc2. Links to binary installers will be sent to the julia-users and julia-news mailing lists. We have branched for release-0.5 - new development will take place on master which is now 0.6-dev, and bug fixes will be backported to the release-0.5 branch according to the steps described at https://github.com/JuliaLang/julia/issues/17418#issue-165613676. A prepared tarball (the output of make light-source-dist) is attached below in julia-0.5.0-rc2.tar.gz, use this if a source tarball is desired, as it contains a small amount of preparation that a simple archive of the git repository does not. For source builds in restricted environments (e.g. no network access) use the output of make full-source-dist attached below in julia-0.5.0-rc2-full.tar.gz as it already contains all dependencies pre-downloaded and ready for compilation.
Changes in sterol and phospholipid fatty acid composition in Refsum's disease fibroblasts grown in the presence of phytol. (1985)

Fibroblasts derived from an individual with Refsum's disease (GM 3896) and a normal control (GM 1717) were grown in the presence of 0, 0.1, 0.2, and 0.3 mM phytol. Cultures were analyzed for total sterol content, and the fatty acid composition of the extractable phospholipids. The fatty acid composition of the phospholipids are similar for control and Refsum's disease fibroblasts when grown on media lacking phytol. However, the addition of phytol to the growth medium produces differences in fatty acid composition between the phospholipids extracted from control and Refsum's disease cells. With regard to sterol composition, data are presented which suggest that an altered sterol is induced in Refsum's disease fibroblasts by the presence of phytol in the growth medium. The possible relationship of these findings to the mechanism of Refsum's disease is discussed.
Direct and indirect continuous-time identification in dynamic networks (2014)

Many systems can be modelled as networks of interconnected continuous-time transfer functions. The coefficients of the transfer functions in the network are often directly related to physical properties of the system. Thus, the question we consider is: under what conditions is it possible to obtain a consistent estimate of a continuous-time transfer function embedded in a dynamic network? We consider both direct and indirect continuous-time approaches. We show that a discrete-time model of a continuous-time data generating system may have a different interconnection structure (due to aliasing) and may have algebraic loops (due to the intersample behaviour). Subsequently we present an instrumental variable based method to directly identify a continuous-time transfer function embedded in a network.
Groin lymph node detection and sentinel lymph node biopsy in vulvar cancer (2016)

Minimally invasive surgery after preoperative evaluation on MRI and SLN biopsy is a feasible strategy for patients with vulvar cancer.
Simultaneous measurement of the velocity and the displacement of the moving rough surface by a laser Doppler velocimeter (1997)

A formula that can analyze the laser Doppler velocimeter spectrum was derived. The formula showed good agreement with computational experimental results. The use of a Fourier transform lens as detection optics was proposed and was found to be independent of the displacement of the object along the direction parallel to the optical axis. An experimental method was also proposed that can make the simultaneous measurement of velocity and displacement possible simply by adding a second detector. By using two detectors, not only can displacement of the surface be measured, but also the results of the speed measurement can be compensated for.
The Influence of Chemical EOR on Produced Water Separation and Quality (2015)

Abstract The use of alkaline surfactant polymer flooding techniques is becoming more commonplace, particularly in projects where heavier and more viscous crude oil is produced. While the efficacy of increasing recovery factors cannot be disputed, often there is little consideration given to the implications of these EOR chemicals breaking through into producer wells and entering the produced water handling system. The impact caused by EOR chemical breakthrough can be varied, but most commonly the efficacy of oil/water separation is seriously affected. The contribution that EOR chemicals can have on reservoir souring is often underestimated, as is the effect they can have upon standard production chemicals such as scale and corrosion inhibitors. The following paper discusses the oil in water and water in oil emulsion issues during an alkaline surfactant polymer flooding pilot in Asia.
135: Economic Evaluation of Finasteride in Benign Prostatic Hyperplasia Treatment (2004)

You have accessJournal of UrologyDiscussed Poster, Saturday, May 8, 2004, 1:00 - 5:00 pm1 Apr 2004135: Economic Evaluation of Finasteride in Benign Prostatic Hyperplasia Treatment J. Curtis Nickel, Heather McDonald, Marg Hux, Marc Brisson, and Lisa Bernard J. Curtis NickelJ. Curtis Nickel More articles by this author , Heather McDonaldHeather McDonald More articles by this author , Marg HuxMarg Hux More articles by this author , Marc BrissonMarc Brisson More articles by this author , and Lisa BernardLisa Bernard More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)37397-XAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "135: Economic Evaluation of Finasteride in Benign Prostatic Hyperplasia Treatment." The Journal of Urology, 171(4S), pp. 35–36 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 171Issue 4SApril 2004Page: 35-36 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information J. Curtis Nickel More articles by this author Heather McDonald More articles by this author Marg Hux More articles by this author Marc Brisson More articles by this author Lisa Bernard More articles by this author Expand All Advertisement PDF DownloadLoading ...
Numerical Simulation of the Effect of Freeze–Thaw Cycles on the Durability of Concrete in a Salt Frost Environment (2021)

In order to improve the accuracy of the analysis of the impact of freeze–thaw cycle on concrete durability in a salt freezing environment, the numerical simulation of the impact of the freeze–thaw cycle on concrete durability in a salt freezing erosion environment is studied in this paper. Firstly, considering the influence of axial force and bending moment on the relationship between bending moment and curvature, a concrete fiber beam column model is established. Then, according to the joint influence of temperature field, stress field and seepage field on concrete in the process of freezing and thawing, the control differential equation of the freezing and thawing cycle is established. The freeze–thaw damage section is divided, the non-uniform distribution of freeze–thaw damage is determined, and the division of the freeze–thaw damage section is completed. According to the linear relationship between freeze–thaw damage degree, relative dynamic elastic modulus, freeze–thaw cycle times and position variables, the durability of concrete is numerically simulated, and the attenuation law of bond strength at different section depths after freeze–thaw is determined. The results show that the temperature curve simulated by the design method is consistent with the actually measured temperature curve, which can better reduce the temperature change of the inner core of the test block during freezing and thawing, and the relative dynamic elastic modulus is in good agreement with the actual value, which can prove that the method in this paper has certain practical application value. It is expected to provide some reference for solving the durability problem of concrete in a salt frost erosion environment and the optimal design of concrete structures.
Foam Analysis at Elevated Pressures for Enhanced Oil Recovery Applications (2018)

A novel foam analyzing system is presented in this work for a systematical and scientifically based investigation of foaming capacity, structure, and stability under process conditions relevant for enhanced oil recovery. The foam height and structure are detected simultaneously as a function of foam age. The apparatus has an extended optical access by means of three tongue-shaped high-pressure windows. A special arrangement of prisms allows for the detection of bubble shapes and size distribution at the same time. The results show a substantial difference of foams generated using compressed gases compared to atmospheric conditions. At pressures rising to 15 MPa, nitrogen foams become increasingly stable, while instable and metastable CO2 foams require a special selection of surfactants and foam stabilizers. As a result of the higher solubility of CO2 in the film phase, Ostwald ripening and coalescence play an important role in decay of CO2 foams, while these mechanisms are hardly observed in N2 foams.
Computational and experimental study of pressure losses in duct transitions (1996)

This paper is concerned with numerical prediction and experimental measurement of air flow and pressure distribution in rectangular ducts with transitions. The constant-injection tracer-gas technique was used to measure mean air velocity in the ducts. Pressure distribution along the ducts was measured using static pressure tappings. The pressure loss coefficient was calculated from the measured pressure loss and air velocity. Computational fluid dynamics was used to predict air flow and pressure distribution in the ducts. The predicted pressure loss coefficient was in good agreement with experimental results for a duct with a contraction.
ChemInform Abstract: OXAZEPINES AND THIAZEPINES, III. SYNTHESIS OF 2,3‐DIHYDRO‐2,4‐DIPHENYL‐1,5‐BENZOTHIAZEPINES BY THE REACTION OF 2‐AMINOTHIOPHENOL WITH CHALCONES SUBSTITUTED IN RING A (1977)

Abstract Die Reaktion der Aminothiophenole (I) mit den Chalkonen (II), (IV) bzw. (VI) liefert je nach dem Substituenten in Ring Adie Propiophenone (III), sowie die Thiazepine (V) bzw. (VII).Erhitzen von (III) in methanolischer Lösung und in Gegenwart katalytischer Mengen Essigsäure ergibt die Thiazepine (VIII).
Mutagenic study on HIV-1 reverse transcriptase to explore the mechanism of action of HIV-1 reverse transcriptase dual inhibitors (2012)

Background. The HIV-1 RT has two associated activities: i) the DNA polymerase activity (both RNA and DNA dependent) and ii) the ribonuclease H (RNase H) activity, that selectively degrades the RNA strand of the RNA/DNA hybrid formed during the reverse transcription process. The HIV-1 RT-associated RNase H function is one of the several steps of the HIV-1 life cycle that are potentially vulnerable to a specific inhibition. Several studies have demonstrated that the abolition of the HIV-1 RNase H function stops the virus replication. All RT inhibitors currently approved for the treatment of HIV infection inhibit the RT polymerase activity, while none of them block the RT associated RNase H activity. Until now, only a few compounds have been reported to inhibit the HIV-1 RNase H function. However, with very few exceptions, they are not truly selective for the HIV-1 RT-associated RNase H activity since most of them inhibit also the HIV-1 RT-associated RDDP activity or the RNase H from other organisms. Since several years we have been engaged in the design and synthesis of RNase H inhibitors. Methods. Recently, we have discovered a new class of RNase H selective inhibitors characterized by quinolonyl carboxylic acid and 5,6-dihydroxybenzopyranone scaffolds and tested them on the HIV-1 RT-associated RNase H function. Results. The preliminary data showed that newly synthesized compounds inhibited the HIV-1 RT-associated RNase H function in the low micromolar range. Conclusions. SAR analysis and mode of action of the inhibitors will be discussed
Coherence revival multiplexed, buffered swept source optical coherence tomography: 400  kHz imaging with a 100  kHz source (2014)

The effective speed of a swept source optical coherence tomography (SSOCT) imaging system was quadrupled using efficient sweep buffering along with coherence revival and spatial multiplexing. A polarizing beam splitter and fold mirror assembly were used to create a dual spot sample arm with a common objective designed for near-diffraction-limited retinal imaging. Using coherence revival, a variable optical delay line allowed for separate locations within a sample to be simultaneously imaged and frequency encoded by carefully controlling the optical path length of each sample path. This method can be used to efficiently quadruple the imaging speed of any SSOCT system employing a low duty-cycle laser that exhibits coherence revival. The system was used to image the retina of healthy human volunteers.
TGFβ Signaling and Cardiovascular Diseases (2012)

Transforming growth factor β (TGFβ) family members are involved in a wide range of diverse functions and play key roles in embryogenesis, development and tissue homeostasis. Perturbation of TGFβ signaling may lead to vascular and other diseases. In vitro studies have provided evidence that TGFβ family members have a wide range of diverse effects on vascular cells, which are highly dependent on cellular context. Consistent with these observations genetic studies in mice and humans showed that TGFβ family members have ambiguous effects on the function of the cardiovascular system. In this review we discuss the recent advances on TGFβ signaling in (cardio)vascular diseases, and describe the value of TGFβ signaling as both a disease marker and therapeutic target for (cardio)vascular diseases.
Limiting dilution analysis of IL-2 producing cells: I. Studies of normal human peripheral blood. (1993)

Here we report a rapid and quantitative technique of limiting dilution analysis that can estimate the frequency of peripheral blood mononuclear cells capable of secreting interleukin-2 following interaction with specific alloantigen.
Remarkable Mechanisms in Microbes to Resist Phage Infections (2014)

Bacteriophages (phages) specifically infect bacteria and are the most abundant biological entities on Earth. The constant exposure to phage infection imposes a strong selective pressure on bacteria to develop viral resistance strategies that promote prokaryotic survival. Thus, this parasite-host relationship results in an evolutionary arms race of adaptation and counteradaptation between the interacting partners. The evolutionary outcome is a spectrum of remarkable strategies used by the bacteria and phages as they attempt to coexist. These approaches include adsorption inhibition, injection blocking, abortive infection, toxin-antitoxin, and CRISPR-Cas systems. In this review, we highlight the diverse and complementary antiphage systems in bacteria, as well as the evasion mechanisms used by phages to escape these resistance strategies.
A simple and practical preparation of an efficient water soluble olefin metathesis catalyst (2015)

A facile gram-scale preparation of a di-ammonium functionalised Ru-alkylidene complex which efficiently catalyses ring-closing metathesis and cross-metathesis reactions in water.
Redox Control of Multidrug Resistance and Its Possible Modulation by Antioxidants (2016)

Clinical efficacy of anticancer chemotherapies is dramatically hampered by multidrug resistance (MDR) dependent on inherited traits, acquired defence against toxins, and adaptive mechanisms mounting in tumours. There is overwhelming evidence that molecular events leading to MDR are regulated by redox mechanisms. For example, chemotherapeutics which overrun the first obstacle of redox-regulated cellular uptake channels (MDR1, MDR2, and MDR3) induce a concerted action of phase I/II metabolic enzymes with a temporal redox-regulated axis. This results in rapid metabolic transformation and elimination of a toxin. This metabolic axis is tightly interconnected with the inducible Nrf2-linked pathway, a key switch-on mechanism for upregulation of endogenous antioxidant enzymes and detoxifying systems. As a result, chemotherapeutics and cytotoxic by-products of their metabolism (ROS, hydroperoxides, and aldehydes) are inactivated and MDR occurs. On the other hand, tumour cells are capable of mounting an adaptive antioxidant response against ROS produced by chemotherapeutics and host immune cells. The multiple redox-dependent mechanisms involved in MDR prompted suggesting redox-active drugs (antioxidants and prooxidants) or inhibitors of inducible antioxidant defence as a novel approach to diminish MDR. Pitfalls and progress in this direction are discussed.
Toward Non-Invasive Core Body Temperature Sensing (2021)

This paper aims to explore the potential of a novel radiometry technique that leverages bio-matched antennas (BMAs), broadband measurements, and forward modeling of layered tissues for non-invasive and accurate core temperature monitoring. Our approach relies on the observation that electromagnetic waves penetrate to different depths depending on their frequency and dielectric properties of the medium and adapts radiative transfer models that have been successfully implemented in the past for layered geophysical media. Preliminary modeling and experimental results confirm feasibility.
Abstract interpretation of reactive systems (1997)

The advent of ever more complex reactive systems in increasingly critical areas calls for the development of automated verification techniques. Model checking is one such technique, which has proven quite successful. However, the state-explosion problem remains a major stumbling block. Recent experience indicates that solutions are to be found in the application of techniques for property-preserving abstraction and successive approximation of models. Most such applications have so far been based solely on the property-preserving characteristics of simulation relations. A major drawback of all these results is that they do not offer a satisfactory formalization of the notion of precision of abstractions. The theory of Abstract Interpretation offers a framework for the definition and justification of property-preserving abstractions. Furthermore, it provides a method for the effective computation of abstract models directly from the text of a program, thereby avoiding the need for intermediate storage of a full-blown model. Finally, it formalizes the notion of optimality, while allowing to trade precision for speed by computing suboptimal approximations. For a long time, applications of Abstract Interpretation have mainly focused on the analysis of universal safety properties, i.e., properties that hold in all states along every possible execution path. In this article, we extend Abstract Interpretation to the analysis of both existential and universal reactive properties, as expressible in the modal -calculus. It is shown how abstract models may be constructed by symbolic execution of programs. A notion of approximation between abstract models is defined while conditions are given under which optimal models can be constructed. Examples are given to illustrate this. We indicate conditions under which also falsehood of formulae is preserved. Finally, we compare our approach to those based on simulation relations.
A phase I/IIa trial of the RNA oligonucleotide STNM01 by EUS-FNI to investigate the safety and efficacy in patients with first-line refractory, unresectable pancreatic cancer. (2021)

4120 Background: Carbohydrate sulfotransferase 15 (CHST15) is an enzyme that synthesizes heavily sulfated matrix glycosaminoglycan and shown to promote tumor invasion and correlate with poor prognosis in pancreatic ductal adenocarcinoma (PDAC). To explore the role of CHST15 blockage, we conducted a Phase I/IIa (P I/IIa) study to investigate the safety and efficacy of EUS guided locoregional injection of STNM01, a synthetic RNA oligonucleotide, in patients with unresectable PDAC, refractory to first-line chemotherapy. Methods: This was an open-label and dose-escalation study of STNM01 as second-line (2L) therapy in unresectable PDAC patients at 4 centers in Japan. One cycle consists of locoregional injection with STNM01 three times at 2 week-interval in 4 weeks (Days 0, 14 and 28 of dosing) in combination with systemic 2L chemotherapy. A 3+3 dose cohort escalation design initiated with 250 nM (n = 3) followed by 1,000 nM (n = 3), 2,500 nM (n = 3) and 10,000 nM (n = 4) was used for P I part. P IIa part (n = 9) was subsequently conducted with MTD or the highest dose level determined by P I. The primary outcome was incidence of DLT at the end of cycle 1. The secondary outcomes included overall survival (OS), local tumor response, histology and safety. This study was registered with jRCT (jRCT2031190055). Results: A total of 22 patients across 4 doses were enrolled in the study of which 21 were evaluable as per protocol population. All patients received S-1 as a systemic 2L chemotherapy and total 3 cycles were repeated at maximum. The most common AEs were abdominal pain and pyrexia. There were 9 grade 3 AEs. No drug-related SAE as well as DLT was observed. Since MTD was not reached in P I, P IIa was conducted with the highest dose, 10,000 nM. The 6-month survival rate in the entire population (n = 21) and in the highest dose population (n = 12; 3 for P I and 9 for P IIa) was 66.7 and 83.3%, respectively. In histological analyses, the % positive area of CHST15 tended to show dose-dependent suppression at the end of cycle 1, especially with 70.0% reduction from baseline in the highest dose population. Increased tumoral infiltrations of CD3 + , CD8 + and CD20 + cells were observed during study period in the highest dose population. Local tumor response for the entire population showed 14 patients (66.7%) with stable disease. Notably, one patient showed complete disappearance on the CT image of both primary and metastatic tumors in the regional lymph node. Conclusions: Repeated locoregional injection of STNM01 is safe and well tolerated in patients with unresectable PDAC as combined 2L therapy. The 6-month survival rate of 10,000 nM of STNM01 was 83.3%, which is remarkable compared with previously reported data. Unexpected mode of action for tumoral lymphocyte infiltration also suggests the promising potential of locoregional injection of STNM01 as a new therapeutic option for PDAC. Clinical trial information: jRCT2031190055.
Maximizing Individual Well Performance (1967)

Abstract This paper discusses the maximizing of the performance of individual wells through the use of the sonic liquid level instrument for obtaining accurate liquid level data. The theory of well production is covered, and the pumping equipment used is described. Introduction Maximizing individual well performance is one of the important steps in efficiently producing oil. This job exists from the day a well is completed until the day it is plugged. The task consists of daily field observation, supplemented by detailed examination of well records and well data. The sonic liquid level instrument offers valuable supplemental information as downhole pressures can be determined from the depth-to-liquid measurement. Efficient well performance results in considerably more oil in a shorter period of time. A barrel of oil produced today through better production methods is worth many times the barrel of oil that is produced years from now when the income barely exceeds the expenses.