gebhart/patrepeval huggingface dataset:
P.140: Impact of Successful Pancreas Transplantation on Patient Reported Hypoglycemia Outcomes (2021)

Introduction: Poorly controlled Type 1 Diabetes (T1D) is associated with increased HbA1c, increased severe hypoglycemia, decreased hypoglycemia awareness and diabetic ketoacidosis. These comorbidities and decreased quality of life are indications for Pancreas Transplantation (PT). Limited data are available about patient reported outcomes (PROs) related to Hypoglycemia after PT. Therefore, we prospectively studied these PROs over a year after PT in patients with T1D. Methods: Ten PT recipients were enrolled within a month after PT and completed 3 visits (V1, V2 & V3 at 4 weeks, 4 months and 1 year). At each visit, participants completed Hypoglycemia Fear Survey-II (HFS-II) and Clarke hypoglycemia unawareness survey. HFS-II is a 33-item questionnaire to measure behavior and worry subscales related to fear of hypoglycemia in patients with T1D. Behavior subscale (HFS-B) describes behaviors individual would engage in to avoid hypoglycemia or its consequences. Worry subscale (HFS-W) describes concerns related to hypoglycemia. Clarke questionnaire evaluates awareness of hypoglycemia based on responses to 8 questions, identifying awareness (A) or reduced awareness (R). The Clarke R score ranges from 0 to 7 with ≤ 2 indicating normal A, 3 as undetermined A and score ≥4 suggesting impaired awareness of hypoglycemia (IAH). We analyzed insulin independent and partial graft function on insulin separately. Statistical analysis was done using a linear mixed effects model. Results: Patients were 46.3 ± 14.3 years old, 9 F, duration of T1D 27.8 ± 15.8 years with 29.4 ± 18.3 days interval from PT. Laboratory results were HbA1c (%) 6.3, 5.4 and 5.4, fasting plasma glucose (mg/dL) 88.6, 104.8 and 91 and C-peptide (ng/ml) 4.6, 3.1 and 2.4 on V1, 2 & 3 respectively. In insulin independent participants (n=8), HFS-B showed almost every participant reported taking some behavioral measures over last 6 months to avoid hypoglycemia at V1. On V2, five participants took some behavioral measures and on V3 only one to avoid hypoglycemia (Table). HFS-W showed almost every participant had some concerns about low blood sugar at V1, five on V2 and none on V3. Two participants who had partial graft function around V2 engaged in behavior to avoid hypoglycemia on V1, 2 & 3, with a subsequent decreased behavioral engagement (p 0.1197) and concern to avoid hypoglycemia (p 0.1391) compared to V1. Clarke scoring showed indeterminate awareness at V1, improved significantly (p 00.0146) and attained normal hypoglycemia awareness over the year on V2 and V3 respectively (Table). Two participants who had partial graft failure reported IAH on all 3 visits (V1: V2:V3=5.0: 4.0: 4.0, p 0.5000). Conclusion: PT recipients reported reduced Fear of hypoglycemia and improved hypoglycemia awareness over a period of 1 year, even in patients with partial graft function. More studies would enable better assessment of these PROs and improve the field.
Preparation of High Performance Pt Counter Electrodes on Conductive Plastic Substrate for Flexible Dye-Sensitized Solar Cells (2013)

Pt counter electrodes (CE) were been prepared using ion sputtering method on indium-doped tinoxide coated polyethylene terephthalate (ITO-PET) for ﬂexible dye-sensitized solar cells (DSSCs). The effect of sputtering time on the properties was characterized by Feld emission scanning electron microscope (FESEM), electrochemical impedance (EIS) and UV-vis absorption spectra. The flexible CE show increased catalytic activity but reduced transmittance when the sputtering time is increased from 0 to 80 s. The light-to-electricity conversion efﬁciency of the DSSCs assembled with the high catalytic activity ﬂexible CE attained a conversion efﬁciency of 4.0% by using Ti foil as the photoanode substrate under the simulated AM 1.5 sunlight. The results reveal that ion sputtering is an effective method for depositing platinum nanoparticles on plastic substrates with low cost under room-temperature.
High‐Quality Electrochromic Polythiophenes via BF3·Et2O Electropolymerization (2003)

Abstract Electrochemical polymerization in the strong Lewis acid, boron trifluoride ethylether (BFEE), has been used to prepare electrochromic polythiophene (PTh) and its derivatives: poly(3‐methylthiophene) (PMeTh), poly(3‐bromothiophene) (PBrTh), and poly(3,4‐dibromothiophene) (PDBrTh). The polymerization processes and properties of the resultant films are compared, where possible, to those carried out in traditional organic electrochemical solvents. The polymerization of these high oxidation potential thiophene monomers in BFEE yielded good‐quality, homogenous, and smooth electroactive and electrochromic films that could be repeatedly switched in common electrochemical solvents up to 240, 1380, 560, and 420 cycles for PTh, PMeTh, PBrTh, and PDBrTh, respectively, for 50 % retention of electroactivity. A colorimetric study of these films showed distinctive color changes between red and blue as they were switched between reduced and oxidized states. These findings allow the use of commercially available high oxidation potential thiophene monomers to provide electrochromic polymers, avoiding the use of other custom‐synthesized monomers.
Intracellular Redistribution of Truncated La Protein Produced by Poliovirus 3C pro -Mediated Cleavage (1999)

The La autoantigen (also known as SS-B), a cellular RNA binding protein, may shuttle between the nucleus and cytoplasm, but it is mainly located in the nucleus. La protein is redistributed to the cytoplasm after poliovirus infection. An in vitro translation study demonstrated that La protein stimulated the internal initiation of poliovirus translation. In the present study, a part of the La protein was shown to be cleaved in poliovirus-infected HeLa cells, and this cleavage appeared to be mediated by poliovirus-specific protease 3C (3Cpro). Truncated La protein (dl-La) was produced in vitro from recombinant La protein by cleavage with purified 3Cpro at only one Gln358-Gly359 peptide bond in the 408-amino-acid (aa) sequence of La protein. The dl-La expressed in L cells was detected in the cytoplasm. However, green fluorescence protein linked to the C-terminal 50-aa sequence of La protein was localized in the nucleus, suggesting that this C-terminal region contributes to the steady-state nuclear localization of the intact La protein in uninfected cells. The dl-La retained the enhancing activity of translation initiation driven by poliovirus RNA in rabbit reticulocyte lysates. These results suggest that La protein is cleaved by 3Cpro in the course of poliovirus infection and that the dl-La is redistributed to the cytoplasm. dl-La, as well as La protein, may play a role in stimulating the internal initiation of poliovirus translation in the cytoplasm.
Plasma Glycine Concentration but Not Whole Body Production Production Rate Is a Marker of Abdominal Obesity in Older Adults Independent of the Presence of a Chronic Disease (2022)

Previously, in healthy older adults, the concentration of the plasma amino acid glycine was found to be negatively related to the amount of visceral adipose tissue (VAT). It remains unclear whether this is due to alterations in the whole body glycine production, and independent of the presence of a concomitant chronic disease in older adults (e.g., Chronic Obstructive Pulmonary Disease (COPD)). In this study, 88 healthy older adults (40 males/48 females) and 122 older adults with stable moderate to severe COPD (58 males/64 females) were studied. In all subjects, body composition and VAT (by DXA) were assessed, as well as muscle function (respiratory strength by mouth pressure, hand- and leg peak strength and endurance by dynamometers) and Charlson Comorbidity index. We also measured plasma concentration and whole body production (WBP) of glycine using stable isotope techniques and analyzed them by LC-MS/MS. Statistics performed by ANCOVA included age, gender, and body mass index as covariates. Significance was set at p < 0.05 and results were expressed as means [95% CI]. Although plasma glycine concentration was comparable between healthy and COPD older adults (p = 0.21), a negatively association was found with VAT area (p < 0.0002; Slope −0.08 [−0.07, −0.10] μM/cm2 VAT) in the total group as well as in the healthy and COPD subgroups. The ROC area was 0.8801 [0.8329, 0.9273] when separating VAT at 800 cm2. WBP of glycine was also not different between healthy older adults and those with COPD but no significant relationship was found with VAT area (p = 0.49). Also no association was found between VAT and any of the other measured parameters. Independent of the presence of COPD, a lower plasma glycine concentration, but not the whole body glycine production, relates to a higher amount of visceral fat in older adults. We conclude that plasma glycine concentration is a marker of the amount of visceral adipose tissue in older adults independent of the presence of a chronic disease. None.
Matthew Turk Moore DDD Semifinalist App (2014)

This is my semi-finalist application for the Moore Data Driven Discovery proposal.
Breaking ambiguities in mixed state ptychography (2016)

Recent advances in ptychographic imaging have shown how the technique extends naturally to mixed state experiments, for example when the illuminating radiation is partially coherent or when the object being imaged is laterally vibrating. To date, experiments using this mixed-state form of ptychography have relied on decomposition of the illumination 'probe' into multiple modes. In this paper we demonstrate, for the first time, ptychographic imaging with the simultaneous presence of both multiple probe and multiple object states. Our results prompt a discussion of uniqueness in the reconstructed images, and we show mathematically how ambiguities can arise. This leads us to extend the reconstruction process to include additional constraints that break these ambiguities, allowing interpretation of mixed object states that are not orthogonal.
Genomic and transcriptomic analysis of imatinib resistance in gastrointestinal stromal tumors (2016)

Gastrointestinal stromal tumors represent the most common mesenchymal tumor of the digestive tract, driven by gain-of-function mutations in KIT. Despite its proven benefits, half of the patients treated with imatinib show disease progression within 2 years due to secondary resistance mutations in KIT. It remains unclear how the genomic and transcriptomic features change during the acquisition of imatinib resistance. Here, we performed exome sequencing and microarray transcription analysis for four imatinib-resistant cell lines and one cell line briefly exposed to imatinib. We also performed exome sequencing of clinical tumor samples. The cell line briefly exposed to imatinib exhibited few single-nucleotide variants and copy-number alterations, but showed marked upregulation of genes related to detoxification and downregulation of genes involved in cell cycle progression. Meanwhile, resistant cell lines harbored numerous genomic changes: amplified genes related to detoxification and deleted genes with cyclin-dependent kinase activity. Some variants in the resistant samples were traced back to the drug-sensitive samples, indicating the presence of ancestral subpopulations. The subpopulations carried variants associated with cell death. Pre-existing cancer cells with genetic alterations promoting apoptosis resistance may serve as a basis whereby cancer cells with critical mutations, such as secondary KIT mutations, can establish full imatinib resistance. © 2017 The Authors Genes, Chromosomes and Cancer Published by Wiley Periodicals, Inc.
Leaf Hairs in Encelia (Asteraceae) (1987)

Four different kinds of leaf hairs occur in Encelia species. These are unicellular-based and multicellular-based uniseriate hairs, moniliform hairs, and biseriate glandular hairs. The unicellular-based uniseriate hairs appear responsible for increased leaf spectral reflectance by species within the genus. In particular, it appears that elongation of the distal cell of the uniseriate hair is necessary for increased leaf reflectance.
Infrared laser absorption spectroscopy of the ν4(σu) fundamental and associated ν11(πu) hot band of C7: Evidence for alternating rigidity in linear carbon clusters (1991)

The first characterization of the bending potential of the C7 cluster is reported via the observation of the v=11 and v=20 levels of the ν11(πu) bend as hot bands associated with the ν4(σu) antisymmetric stretch fundamental. The lower state hot band rotational constants are measured to be 1004.4(1.3) and 1123.6(9.0) MHz, constituting a 9.3% and 22% increase over the ground state rotational constant [918.89(41) MHz]. These large increases are strong evidence for extremely large amplitude, anharmonic bending modes in this cluster. In addition, quartic and sextic centrifugal distortion constants determined for the ground and ν4=1 states are found to be anomalously large and negative, evidencing strong perturbations between stretching and bending modes.
Interdependent Benefits from Interorganizational Systems: Opportunities for Business Partner Reengineering (1994)

:Managing the growth of interorganizational systems (IOS), such as electronic data interchange (EDI), and the adoption decisions of trading partners have become major concerns for network managers. The fact that IOS are shared by separate trading partners means that the benefits from IOS are both unequal and interdependent. Therefore, how trading partners implement and use the system internally may directly affect the original firm’s benefit. In order to maximize benefits from IOS, we propose that firms engage in business partner reengineering.We study two buyer-initiated EDI systems where the way in which trading partners internally implement the technology directly affects the level of benefit for the initiating buyer. In both cases, the buyer’s benefit is increased when suppliers choose to adopt an optional buyer-initiated modification to their system. However, because it is not clear how suppliers benefit from the modification, they may not have adequate incentives to make the modification. Buyers with substantial leverage over their suppliers may require trading partners to implement the system in a particular way or not be considered for future business.
Supplementary Appendix from Nivolumab in Patients with Advanced Platinum-resistant Urothelial Carcinoma: Efficacy, Safety, and Biomarker Analyses with Extended Follow-up from CheckMate 275 (2023)

&lt;p&gt;This appendix includes all supplemental tables and figures referenced in the article.&lt;/p&gt;
The ISO internetwork protocol standard (1984)

A great deal has already been written about the development by the International Organization for Standardization of a Reference Model for Open Systems Interconnection. The Reference Model provides a framework for the development of standards for the interconnection of computer and terminal equipment. It describes an architecture wherein functions ascribed to providing communications are separated into a hierarchy of seven layers. Each layer provides services to the next higher layer, utilizing the services provided by subordinate layers in order to achieve that end. At each layer, protocols are employed to convey information between peer layer entities in individual systems. When in compliance with a suite of standard protocols prescribed for OSI, systems are considered to be "open".
Chemicals from Biomass: Petrochemical Substitution Options (1981)

As a source of chemicals, biomass has several intrnsic advantages over fossil mass: it is renewable, flexible through crop switching, and adaptable through genetic manipulation. Inflexibility of the fossil mass resource is compensated for by highly effective technology for production of olefins and aromatics, economies of scale, and a highly developed system of conversion products with large markets. Direct and indirect strategies to substitute for petrochemicals are based on ecological succession concepts. A proliferation of lignocellulosic fractionation processes is arising from the need for inexpensive, homogeneous, chemically useful biomass feedstocks.
Improvement of transcription- and transfection-efficiency by synthetic polyampholytes (2008)

Water-soluble PEG derivatives having both amino- and carboxyl-pendants (PEG-ACs) were synthesized, and examined for their transcription- and transfection-enhancing activity on DNA/polycation complexes. PEG-AC could be deposited onto the surface of DNA/polyethylenimine(PEI) complexes, and enhanced their transcriptional activity. Fluorescence anisotropy study showed that the amphoteric PEG-AC loosened the tightly compacted DNA/PEI complex to facilitate the approach of transcriptional factors. Transcriptional activity of the complex was in good correlation with its transgene expression efficiency, indicating the importance of improvement in transcription for effective gene transfection.
ChemInform Abstract: Thalidomide Metabolites and Analogues. Part 2. Cyclic Derivatives of 2‐N‐Phthalimido‐2S,3S(3‐hydroxy)ornithine. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Monotherapy efficacy of BBB-permeable small molecule activators of PP2A in glioblastoma (2019)

Abstract Glioblastoma (GB) is a fatal disease in which most targeted therapies have clinically failed. However, pharmacological reactivation of tumor suppressors has not been thoroughly studied as yet as a GB therapeutic strategy. Tumor suppressor Protein Phosphatase 2A (PP2A), is inhibited by non-genetic mechanisms in GB, and thus it would be potentially amendable for therapeutic reactivation. Here we demonstrate, that s mall m olecule a ctivators of P P2A (SMAPs), NZ-8-061 and DBK-1154, effectively cross the in vitro model of blood-brain barrier (BBB), and in vivo partition to mouse brain tissue after oral dosing. In vitro , SMAPs exhibit robust cell killing activity against five established GB cell lines, and nine patient-derived primary glioma cell lines. Collectively these cell lines have heterogenous genetic background, kinase inhibitor resistance profile, and stemness properties; and they represent different clinical GB subtypes. Oral dosing of either of the SMAPs significantly reduced growth of infiltrative intracranial GB tumors. DBK-1154, with both higher degree of brain/blood distribution, and more potent in vitro activity against all tested GB cell lines, also significantly increased survival of mice bearing orthotopic GB xenografts. In summary, this report presents a proof-of-principle data for BBB-permeable tumor suppressor reactivation therapy for glioblastoma cells of heterogenous molecular background.
Cryo-EM structures reveal dramatic remodeling of the p97 hexamer by the multi-domain adapter UBXD1 (2022)

P97/VCP is an essential AAA+ molecular machine critical for many cellular processes. While the established function of p97 is the ATP-dependent threading of proteins through its central pore, this activity is regulated by adapter proteins that endow critical functions in substrate specificity, cellular localization, and specific enzymatic functions, for example removal of ubiquitin molecules from canonical p97 clients. UBXD1 is a poorly-characterized p97 adapter, and is implicated in p97's roles in autophagic clearance of damaged mitochondria and lysosomes. While UBXD1 binding has been demonstrated to be impaired by disease-causing p97 mutations, indicating its relevance in maintaining cellular homeostasis, details regarding how UBXD1 alters p97 function in the context of the full-length proteins have remained elusive. To better understand how UBXD1 affects p97 function, we determined high-resolution cryo-EM structures of p97-UBXD1 complexes, which reveal that a single UBXD1 molecule disrupts normal p97 protomer-protomer interactions using both annotated and previously uncharacterized p97-interacting domains. An additional state reveals a striking UBXD1-mediated hexamer ring opening, in which contacts between neighboring p97 protomers are completely disrupted. Three-dimensional variability analysis reveals that these structures represent snapshots in a continuous spectrum of p97 ring opening, lending support to the proposed mechanism of UBXD1-dependent p97 remodeling. These results, coupled with biochemical analyses, provide the most comprehensive information to date on the molecular basis for UBXD1's effects on p97 structure and function, and reveal potential roles in regulating p97 substrate processing activity.
Mobilization of Cutaneous Immunity for Systemic Protection Against Infections (1992)

This laboratory reported that a single subcutaneous (SC) injection of the natural steroid hormone dehydroepiandrosterone (DHEA) resulted in significant protection against a lethal herpes virus type 2 encephalitis or a systemic coxsackievirus B4 infection. Our previous results have shown that SC injection of DHEA resulted in upregulation of the specific host immune response resulting in protection against a lethal infection. This hormone did not have any direct antiviral effects in vitro. Furthermore, results indicate that, in vivo, DHEA is not the agent directly mediating the upregulation of the immune response. In the skin, DHEA is converted to androstenediol (AED) and it, in turn, is converted to androstenetriol; this is a metabolic process which appears unique to the skin. This report demonstrates that SC injection of AED results in markedly greater resistance against both viral and bacterial infection. Both DHEA and AED appear to function by facilitating and upregulating host immune responses via mobilization of cutaneous immunity to obtain systemic protection against infections. Because these steroids are native to the host and are regulated by the central nervous system, it is suggested that they may be an integral element of neuroimmunomodulation.
Hydrogen Gas Inhalation Attenuates Acute Impulse Noise Trauma: A Preclinical In Vivo Study (2022)

Acute acoustic trauma can be reduced by H<sub>2</sub> when inhaled immediately after impulse noise exposure.
Precision terrain height measurement sensor (2002)

A precision terrain height measurement sensor has been developed providing 1 inch height accuracy for short range applications. This sensor was developed to provide inputs into an automatic control system for multiple uses, both military and commercial. Military applications include mine plow control and active suspension control. Commercial applications include machine positioning systems for agriculture and road construction, and ride control for off-road vehicles. The system was designed using precision terrain height monopulse/interferometric techniques adapted from airborne terrain following/avoidance, air-to-ground ranging and 3-D reconnaissance modes. A demonstration radar was developed and tested. Accuracy down to 0.3 inches has been demonstrated.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Sodium and Potassium tert-Butyl Peroxide Hydrates: Crystal Structure and Properties (2021)

Abstract Sodium and potassium tert- butyl peroxide hydrates 2Na + ·2C 4 H 9 $${\text{O}}_{2}^{ - }$$ ·7H 2 O ( I ) and 2K + · 2C 4 H 9 $${\text{O}}_{2}^{ - }$$ ·4H 2 O ( II ) were prepared. According to X-ray diffraction data (CIF files CCDC no. 2081025 ( I ) and no. 2081024 ( II )), the compounds are coordination polymers in which alkali metal atoms have C.N.(Na) of 6 or C.N.(K) of 6 and 8. The crystal packings comprise layers with clearly defined hydrophobic surfaces consisting of hydrocarbon groups and hydrophilic inner areas including water molecules, alkali metal cations, and peroxy groups of the tert -butyl peroxide anions. Compounds were characterized by vibrational spectroscopy, 1 H, 13 C NMR spectroscopy, thermogravimetry, and differential scanning calorimetry.