gebhart/patrepeval huggingface dataset:
Boden-Bauwerk-Interaktion unter Berücksichtigung von tiefen- und frequenzabhängigen, viskosen Dämpferelementen an den Halbraumrändern/Depth and frequency dependent dashpots in context of Rayleigh-Wave reflection (2021)

Berechnungen der Boden-Bauwerk-Interaktion unter Berücksichtigung des homogenen Halbraumes beinhalten die Problematik der Wellenreflexion, welche die ungestörten Ergebnisse verstimmt und eine Diskrepanz entstehen lässt. Reflexionsfreie Berechnungen können nur in einem unbegrenzten Halbraum durchgeführt werden, der innerhalb der FEM aber nicht existiert. In der Praxis werden häufig tiefen- und frequenzunabhängige (lineare) viskose Dämpferelemente für die Simulation infiniter Randbedingungen verwendet. Dieser Ansatz geht mit nicht zu vernachlässigenden Reflexionen von Oberflächenwellen, wie der Rayleigh-Welle, einher, welche maßgeblich für die Übertragung von Erschütterungen verantwortlich sind. &amp;nbsp; In diesem Beitrag wird das tiefen- und frequenzabhängige Geschwindigkeitsfeld der Rayleigh-Welle bei der Formulierung der viskosen Dämpferelemente berücksichtigt. Es wird gezeigt, dass auf diese Weise für impulsförmige und harmonische Anregungen die Reflexion der Rayleigh-Welle reduziert werden kann. Aufgrund der geringeren Reflexionen an den Modellrändern verbessert sich die Prognose der Erschütterungsausbreitung.
Active Displacement Control of Active Magnetic Bearing System (2014)

Abstract The worldwide energy production nowadays is over 3400 GW while storage systems have a capacity of only 90 GW [1]. There is a good solution for additional storage capacity in flywheel energy storage systems (FES). The main advantage of FES is its relatively high efficiency especially with using the active magnetic bearing system. Therefore there exist good reasons for appropriate simulations and for creating a suitable magneto-structural control system. The magnetic bearing, including actuation, is simulated in the ANSYS parametric design language (APDL). APDL is used to create the loops of transient simulations where boundary conditions (BC) are updated based upon a “gap sensor” which controls the nodal position values of the centroid of the shaft and the current density inputs onto the copper windings.
Supplementary Methods and Materials, Figures S1-S3, Tables S1-S5 from Phase II Clinical and Exploratory Biomarker Study of Dacomitinib in Patients with Recurrent and/or Metastatic Squamous Cell Carcinoma of Head and Neck (2023)

&lt;p&gt;Supplementary Methods and Materials, Figures S1-S3, Tables S1-S5. 1. Supplementary Methods. page 2-4 -Gene set analysis for gene expression data -Immunohistochemistry and fluorescent in situ hybridization (FISH) -Enzyme-linked immunosorbent assay (ELISA) 2. Supplemental Figures. Figure S1: CONSORT diagram. page 5 Figure S2: Kaplan-Meier estimates of progression-free survival and overall survival according to p16 status. page 6 Figure S3: Analysis of fibroblast growth factor receptor 1 (FGFR1) gene amplification by fluorescent in situ hybridization. page 7 3. Supplemental Tables Table S1: Gene list and platforms for biomarker analysis. page 8-12 Table S2: Loci information of somatic mutations. page 13 Table S3: Gene expression profile in 230 cancer genes. page 14-20 Table S4: Gene set enrichment analysis. page 21-22 Table S5: Copy number aberrations in 86 cancer genes. page 23&lt;/p&gt;
The Impact of the Injection Water Chemistry on Oil Recovery from Carbonate Reservoirs (2012)

Abstract Improved/enhanced oil recovery by tuning the ionic composition of the injection water is currently deemed as new emerging recovery method. In the recent years, extensive research on oil/brine/rock systems has shown that injection low salinity brines in sandstone reservoirs has a significant impact on the amount of oil recovered. Although, the potential for carbonates has not been thoroughly investigated, some reported studies have excluded carbonates from this effect. Based on the research work in the last years, we demonstrated in a previous reports (137634; SPEREE Journal, vol. 14(5), pp. 578-593, SPE 143550, SPE 141082) that substantial oil recovery beyond conventional waterflooding from carbonates can be achieved by optimizing the salinity and ionic composition of field injection brine. Also, research confirmed that the main cause for the substantial increase in oil recovery is wettability alteration of carbonate rock surface. This paper highlights extensive and a broad range of laboratory studies including wettability, surface chemistry, and zeta potential studies to define the role of water ions in the induced wettability alteration, which is crucial in determining the optimum composition of injection water for future field applications. The rock surface chemistry studies identified the potential mechanisms for wettability alteration triggered by injecting chemistry-optimized field injection water. The contact angle results confirmed that a sufficient reduction in the ionic strength of field injection water is required to trigger the effect of wettability alteration. Zeta potential measurements successfully addressed the impact of multivalent ions on rock surface charges. All evidence gathered during this research work indicates that interplay of water ions is important factor in this new recovery method.
T-section dual-band impedance transformer for frequency-dependent complex impedance loads (2011)

A simple and successful design for matching complex impedance loads with different values at two different frequencies is presented. The explicit closed-form equations for the transformer parameters are derived analytically. The validity of the proposed design is verified by a numerical example of designing the input matching network of an amplifier.
Retrospective mathematical analysis of serial prostate specific antigen (PSA) measurements for patients with M0 prostate cancer treated with intermittent androgen suppression (IAS). (2012)

e15201 Background: Recently a phase III trial demonstrated that IAS was non-inferior to continuous AS in men with M0 disease after primary or salvage radiation and quality of life was better in the intermittent arm (Crook ASCO 2011). In that trial, men were treated with 8 months of AS followed by a variable time off AS driven by the absolute PSA value. The Hirata mathematical model describes the dynamics of prostate cancer treated with IAS (Hirata et al, J of Theoretical Biol 2010). In the model, there are three classes of cancer cells: a class of androgen dependent (AD) cells and two classes of androgen independent (AI:X1 and AI:X2) cells. During AS, AD cells will change to the two AI classes, and during the off treatment period, AI:X1 cells will revert to AD cells whereas AI:X2 cells cannot revert to either AD or AI:X1 cells. Methods: After IRB approval, we applied the Hirata model using serial monthly PSAs from men with M0 disease treated with IAS from Japan, Canada, and the United States. The proportions of men from each country who fell into the 3 categories of patients previously defined by the Hirata model were compared. Results: Serial PSAs from 26 men from Japan, 72 from Canada, and 79 from US were put into the model. The 3 categories of patients from the model include: (i) those with disease that will remain androgen sensitive and will respond to IAS without development of castration resistance (CRPC) (ii) those who will benefit from IAS but will develop CRPC sooner than those in group (i), (iii) those for whom continuous AS is superior to IAS. The datasets from each country show a similar distribution among the categories, and overall there were 42%, 51%, and 7% falling into groups i, ii, and iii respectively. Conclusions: This retrospective analysis shows that men with M0 disease treated with IAS fall into the 3 categories predicted by the Hirata model in similar proportions, regardless of country of origin. The ability to apply this model to the individual patient in the clinic is currently under development. The model may ultimately be able to optimize both the on and off treatment durations of IAS and to predict those patients who will most benefit from this approach.
Dihydroergocriptine in Management of Microprolactinomas* (1987)

The effects of dihydroergocriptine (DHECP), a dihydrogenated ergot alkaloid with dopaminergic agonistic and alpha-adrenergic antagonistic properties, were studied in 22 women with PRL-secreting microprolactinomas and compared with those recorded in 36 previously studied patients treated with bromocriptine (BRC). After acute administration of 5 mg DHECP, orally, serum PRL decreased by 61 +/- 18% (+/- SD); only 1 patient was unresponsive. The nadir was reached at 300 min. Long term treatment with increasing DHECP doses caused a progressive PRL fall from 125 +/- 142 (+/- SD) to 81 +/- 159 micrograms/L after 1 week of a 3 mg twice daily regimen, to 64 +/- 88 micrograms/L after 1 week of 5 mg twice daily, 46 +/- 57 micrograms/L after 1 week of 10 mg twice daily, and 28 +/- 34 to 33 +/- 45 micrograms/L throughout 9 months of treatment with 10 mg DHECP 3 times daily. Seventy-seven percent of patients had normal serum PRL levels during chronic treatment. All women, including those with supranormal serum PRL levels, resumed regular menses, and 16 had ovulatory cycles; 1 woman became pregnant. Galactorrhea disappeared in all. During treatment the PRL response to TRH, initially absent in all patients, became positive in 10. In 7 patients, after DHECP treatment for 9 months, high definition computed tomographic scan no longer showed the focal lesions initially seen. After drug withdrawal, serum PRL increased again in all except 1 patient. Two patients had regular menses for 6 months, and 3 still had no adenoma imaged by high definition computed tomography. In BRC-treated patients the serum PRL changes and clinical results were very similar to those in the DHECP-treated patients, except for the persistence of normal serum PRL levels in 4 patients after drug withdrawal. On the other hand, side-effects were negligible during DHECP treatment, but remarkable during BRC. Systolic and diastolic blood pressures decreased by only 5.4 and 3.0 mm Hg, respectively, after acute 5 mg DHECP administration, but decreased by 12.8 and 14 mm Hg after acute 2.5 mg BRC administration. Orthostatic hypotension and peripheral vasomotor phenomena occurred in the long term DHECP treated patients except one, but they occurred in 9 and 3 of those treated with BRC, respectively. Gastric discomfort or mild nausea occurred in 12 DHECP-treated patients, while mild or severe nausea or vomiting were observed in 18, 11, and 2 of those taking BRC, respectively.(ABSTRACT TRUNCATED AT 400 WORDS)
Effect of thermal cycling on martensitic transformation temperatures in Ti–Ni–Cu shape memory alloys (2000)

Changes in martensitic transformation temperatures during thermal cycling in Ti–Ni–Cu shape memory alloys have been investigated by means of electrical resistivity measurements, thermal cycling tests under constant load and transmission electron microscopy. During thermal cycling without applied stress, the B2→B19′ transformation temperature M s decreased, while the B2→B19 transformation start temperature M s′ kept almost constant. During thermal cycling with applied stress, in solution treated Ti–45Ni–5Cu alloy, changes in M s depended on the amount of applied stress. That is, M s decreased when the applied stress was 39.2 MPa, while its value kept almost constant when a stress of 117.2 MPa was applied. It was also found that M s′ increased during thermal cycling in the solution treated Ti–35Ni–15Cu and Ti–30Ni–20Cu alloys, irrespective of the amount of applied stress. All changes in M s and M s′ during thermal cycling with applied stress in Ti–Ni–Cu alloys were explained well by a combination of the thermal cycling effect and the structural refinement effect.
Accélération d’électrons avec des lasers d’un seul cycle optique (2019)

International audience
W071002 Latest Study about Exhaust Heat Recovery System from Internal Combustion Engine : Study of Hydrogen Additive Combustion with Gasoline Fuel Reformer Using Exhaust Heat (2015)

Many types of exhaust heat recovery system on internal combustion engine have been studied. For example, Rankine-cycle steam engine can assist engine torque and thermoelectric element can generate electricity by Seebeck effect with recovering exhaust heat as their heat sources. In this paper, a study on fuel reforming is described as the latest example of exhaust heat recovery. Improvement of combustion stability under higher EGR rate with addition of hydrogen by its high burning velocity can enhance EGR upper limit and lead higher thermal efficiency. In order to realize on-board hydrogen gas generation, a fuel reformer system consist of a reforming catalyst and a fuel injector on an external EGR line is studied and the effect of this system is clarified by a physical single cylinder engine with real reformate gas.
Impact of high-dose oral acyclovir prophylaxis on cytomegalovirus (CMV) disease in CMV high-risk renal transplant recipients. (1996)

Recent studies showed contradictory results concerning the efficacy of oral acyclovir in the prevention or amelioration of cytomegalovirus (CMV) disease after renal transplantation (TX). This study evaluated the incidence and severity of CMV disease within the first year after TX in high-risk renal transplant recipients (CMV-seropositive donor, seronegative recipient) treated prophylactically with oral acyclovir (800 to 3200 mg/day) over a period of 12 wk (ACY, N = 22), compared with high-risk patients randomly assigned as controls (CO, N = 10). Follow-up for CMV infection included serological determination of CMV-specific immunoglobulin G and immunoglobulin M antibodies, antigen detection in peripheral blood leukocytes (PP 65), shell vial culture (blood), and virus isolation/early antigen detection (urine). Severity of CMV disease was quantified by a scoring system for CMV-related symptoms. Nine patients (40.1%) in the acyclovir group and four patients (40%) in the control group developed CMV disease. Neither severity (ACY, 11.4 versus CO; 12.5 points score), nor duration of disease (ACY, 21 days; CO, 22 days), nor transplant function at the end of the observation period differed significantly. The onst of CMV disease was not delayed significantly in acyclovir-treated patients compared with controls (ACY, 47 +/- 34 days versus CO, 27 +/- 14 days after TX, not significant). Our results show no beneficial effect of oral acyclovir prophylaxis in CMV high-risk renal transplant recipients.
Risk Assessment for Highly Pathogenic Avian Influenza A(H5N6/H5N8) Clade 2.3.4.4 Viruses (2021)

The numerous global outbreaks and continuous reassortments of highly pathogenic avian influenza (HPAI) A(H5N6/H5N8) clade 2.3.4.4 viruses in birds pose a major risk to the public health. We investigated the tropism and innate host responses of 5 recent HPAI A(H5N6/H5N8) avian isolates of clades 2.3.4.4b, e, and h in human airway organoids and primary human alveolar epithelial cells. The HPAI A(H5N6/H5N8) avian isolates replicated productively but with lower competence than the influenza A(H1N1)pdm09, HPAI A(H5N1), and HPAI A(H5N6) isolates from humans in both or either models. They showed differential cellular tropism in human airway organoids; some infected all 4 major epithelial cell types: ciliated cells, club cells, goblet cells, and basal cells. Our results suggest zoonotic potential but low transmissibility of the HPAI A(H5N6/H5N8) avian isolates among humans. These viruses induced low levels of proinflammatory cytokines/chemokines, which are unlikely to contribute to the pathogenesis of severe disease.
Discovering beautiful attributes for aesthetic image analysis (2014)

Aesthetic image analysis is the study and assessment of the aesthetic properties of images. Current computational approaches to aesthetic image analysis either provide accurate or interpretable results. To obtain both accuracy and interpretability by humans, we advocate the use of learned and nameable visual attributes as mid-level features. For this purpose, we propose to discover and learn the visual appearance of attributes automatically, using a recently introduced database, called AVA, which contains more than 250,000 images together with their aesthetic scores and textual comments given by photography enthusiasts. We provide a detailed analysis of these annotations as well as the context in which they were given. We then describe how these three key components of AVA - images, scores, and comments - can be effectively leveraged to learn visual attributes. Lastly, we show that these learned attributes can be successfully used in three applications: aesthetic quality prediction, image tagging and retrieval.
A model of cooperative threads (2009)

We develop a model of concurrent imperative programming with threads. We focus on a small imperative language with cooperative threads which execute without interruption until they terminate or explicitly yield control. We define and study a trace-based denotational semantics for this language; this semantics is fully abstract but mathematically elementary. We also give an equational theory for the computational effects that underlie the language, including thread spawning. We then analyze threads in terms of the free algebra monad for this theory.
Transcriptional Control of a Nuclear Gene Encoding a Mitochondrial Fatty Acid Oxidation Enzyme in Transgenic Mice: Role for Nuclear Receptors in Cardiac and Brown Adipose Expression (1996)

Expression of the gene encoding medium-chain acyl coenzyme A dehydrogenase (MCAD), a nuclearly encoded mitochondrial fatty acid beta-oxidation enzyme, is regulated in parallel with fatty acid oxidation rates among tissues and during development. We have shown previously that the human MCAD gene promoter contains a pleiotropic element (nuclear receptor response element [NRRE-1]) that confers transcriptional activation or repression by members of the nuclear receptor superfamily. Mice transgenic for human MCAD gene promoter fragments fused to a chloramphenicol acetyltransferase gene reporter were produced and characterized to evaluate the role of NRRE-1 and other promoter elements in the transcriptional control of the MCAD gene in vivo. Expression of the full-length MCAD promoter-chloramphenicol acetyltransferase transgene (MCADCAT.371) paralleled the known tissue-specific differences in mitochondrial beta-oxidation rates and MCAD expression. MCADCAT.371 transcripts were abundant in heart tissue and brown adipose tissue, tissues with high-level MCAD expression. During perinatal cardiac developmental stages, expression of the MCADCAT.371 transgene paralleled mouse MCAD mRNA levels. In contrast, expression of a mutant MCADCAT transgene, which lacked NRRE-1 (MCADCATdeltaNRRE-1), was not enriched in heart or brown adipose tissue and did not exhibit appropriate postnatal induction in the developing heart. Transient-transfection studies with MCAD promoter-luciferase constructs containing normal or mutant NRRE-1 sequences demonstrated that the nuclear receptor binding sequences within NRRE-1 are necessary for high-level transcriptional activity in primary rat cardiocytes. Electrophoretic mobility shift assays demonstrated that NRRE-1 was bound by several cardiac and brown adipose nuclear proteins and that these interactions required the NRRE-1 receptor binding hexamer sequences. Antibody supershift studies identified the orphan nuclear receptor COUP-TF as one of the endogenous cardiac proteins which bound NRRE-1. These results dictate an important role for nuclear receptors in the transcriptional control of a nuclear gene encoding a mitochondrial fatty acid oxidation enzyme and identify a gene regulatory pathway involved in cardiac energy metabolism.
Interaction of the Vaccinia Virus RNA Polymerase-Associated 94-Kilodalton Protein with the Early Transcription Factor (2009)

A multisubunit RNA polymerase (RPO) encoded by vaccinia virus (VACV), in conjunction with specific factors, transcribes early, intermediate, and late viral genes. However, an additional virus-encoded polypeptide referred to as the RPO-associated protein of 94 kDa (RAP94) is tightly bound to the RPO for the transcription of early genes. Unlike the eight RPO core subunits, RAP94 is synthesized exclusively at late times after infection. Furthermore, RAP94 is necessary for the packaging of RPO and other components needed for early transcription in assembling virus particles. The direct association of RAP94 with NPH I, a DNA-dependent ATPase required for transcription termination, and the multifunctional poly(A) polymerase small subunit/2'-O-methyltransferase/elongation factor was previously demonstrated. That RAP94 provides a structural and functional link between the core RPO and the VACV early transcription factor (VETF) has been suspected but not previously demonstrated. Using VACV recombinants that constitutively or inducibly express VETF subunits and RAP94 with affinity tags, we showed that (i) VETF associates only with RPO containing RAP94 in vivo and in vitro, (ii) the association of RAP94 with VETF requires both subunits of the latter, (iii) neither viral DNA nor other virus-encoded late proteins are required for the interaction of RAP94 with VETF and core RPO subunits, (iv) different domains of RAP94 bind VETF and core subunits of RPO, and (v) NPH I and VETF bind independently and possibly simultaneously to the N-terminal region of RAP94. Thus, RAP94 provides the bridge between the RPO and proteins needed for transcription initiation, elongation, and termination.
Reviving the inter-laboratory comparison measurement results (2019)

Key comparison measurements serve as an ultimate tool of quality assurance of results. Whenever the inter-comparison results indicate inconsistency, the participating laboratory needs to take the corrective actions. Practically, the systematic errors involved in the measuring system confines the achievable accuracy. Therefore, the corrective action involves either empirically determine the influences afresh or intuitively reassigns these error values. Alternatively, an analytical method based on inter laboratory comparison results is proposed. The novelty of the proposal is considering task-specific errors in the model that is used for the analysis of interlaboratory comparison results. Without accounting the uncertainties of task-specific errors, the analysis grows complicated and even sometimes it is not feasible. To supplement the proposed method, task-specific errors due to the imperfect geometry of ring gauge, practical inability in implementing the measurement, and unattended environmental influences are explored. The proposed method is demonstrated using some internal diameter key comparison data. The systematic errors responsible for the outlier in the measurement comparison are clearly distinguished.
On-Chip Diagnosis of Generalized Delay Failures Using Compact Fault Dictionaries (2018)

One approach for achieving a robust integrated system centers on first performing test during runtime, then identifying the locations of any faults (or potential faults), and finally repairing/replacing/avoiding the affected portion(s) of the system. Conventional fault dictionary approaches can be used to locate failures but are limited to simplistic fail behaviors due to the significant computational resources required for dictionary generation and memory storage. Several contributions are described to overcome these limitations, and include: 1) enhancement of an unspecified-transition fault model (called here the transition-X fault model, or TRAX) for capturing the misbehaviors expected from scaled technologies; 2) development of a hierarchical dictionary that only localizes to the level required; and 3) the design of a scalable architecture for retrieving and using the hierarchical dictionary for on-chip failure diagnosis. The OpenSPARC T2 processor and other circuits are used in experiments to demonstrate the low-overhead, accurate diagnosis of early life and wear-out failures, using TRAX dictionaries that are over five orders of magnitude smaller than full-response dictionaries.