gebhart/patrepeval huggingface dataset:
Lighting Up the Tumor—Fluorescein-Guided Resection of Gangliogliomas (2020)

(1) Background: Gangliogliomas comprise a small number of brain tumors. They usually present as World Health Organization (WHO) grade I, and they delineate on gadolinium-enhanced MRI; the surgical goal is wide radical resection, and the course thereafter is usually benign. Fluorescein sodium (FL) tends to accumulate in areas with altered blood-brain barrier (BBB). Thus far, the results provided by prospective and retrospective studies show that the utilization of this fluorophore may be associated with better visualization and improvement of resection for several tumors of the central nervous system. In this study, we retrospectively studied the effect of fluorescein sodium on visualization and resection of gangliogliomas. (2) Methods: Surgical databases in three neurosurgical departments (Regensburg University Hospital; Besta Institute, Milano, Italy; and Liv Hospital, Istanbul, Turkey), with approval by the local ethics committee, were retrospectively reviewed to find gangliogliomas surgically removed by a fluorescein-guided technique by the aid of a dedicated filter on the surgical microscope from April 2014 to February 2020. Eighteen patients (13 women, 5 men; mean age 22.9 years, range 3 to 78 years) underwent surgical treatment for gangliogliomas during 19 operations. Fluorescein was intravenously injected (5 mg/kg) after general anesthesia induction. Tumors were removed using a microsurgical technique with the YELLOW 560 Filter (YE560) (KINEVO/PENTERO 900, Carl Zeiss Meditec, Oberkochen, Germany). (3) Results: No side effects related to fluorescein occurred. In all tumors, contrast enhancement on preoperative MRI correlated with bright yellow fluorescence during the surgical procedure (17 gangliogliomas WHO grade I, 1 ganglioglioma WHO grade II). Fluorescein was considered helpful by the operating surgeon in distinguishing tumors from viable tissue in all cases (100%). Biopsy was intended in two operations, and subtotal resection was intended in one operation. In all other operations considered preoperatively eligible, gross total resection (GTR) was achieved in 12 out of 16 (75%) instances. (4) Conclusions: The use of FL and YE560 is a readily available method for safe fluorescence-guided tumor resection, possibly visualizing tumor margins intraoperatively similar to contrast enhancement in T1-weighted MRI. Our data suggested a positive effect of fluorescein-guided surgery on intraoperative visualization and extent of resection during resection of gangliogliomas.
MR-Guided Focused Ultrasound: A New Generation Treatment of Parkinson's Disease, Essential Tremor and Neuropathic Pain (2014)

The application of high intense focused ultrasound (HIFU) is currently the subject of many experimental and clinical trials. The combination of HIFU with MRI guidance known as MR-guided focused ultrasound (MRgFUS) appears to be particularly promising to ablate tissues located deep in the brain. The method can be the beginning of interventional neurology and an important alternative to neurosurgery. Studies conducted to date show the effectiveness of the method both in chronic diseases and in emergency cases. The safety and effectiveness of this method have been observed in parkinsonian and essential tremor as well as in neuropathic pain. The procedure does not require anaesthesia. Ionizing radiation is not used and there is no risk of cumulative dose. Such advantages may result in low complication rates and medical justification for further development of MRgFUS.
Identifying Selective Host–Guest Interactions Based on Hydrogen Bond Donor–Acceptor Pattern in Functionalized Al-MIL-53 Metal–Organic Frameworks (2013)

We present a study analyzing the selectivity of host–guest interactions in a series of functionalized Al-MIL-53-X metal–organic frameworks with X = H, NH2, and NHCHO using acetone, ethanol, and water as probe molecules. While the amino group introduces additional hydrogen bond donor centers the NHCHO anchors function as donor and acceptor. The guests were chosen due to their ability to act solely as an acceptor in the case of acetone, whereas ethanol and water provide acceptor and donor qualities with a gradual decrease of the acceptor strength toward ethanol. The characterization of the host–guest interactions includes a comprehensive solid-state NMR spectroscopic study based on a full assignment of 1H and 13C high-resolution spectra using CRAMPS decoupling schemes to enhance 1H resolution combined with advanced 2D HETCOR (1H–13C, 1H–27Al, and 1H–14N) spectra at high magnetic fields. In spite of a pronounced dynamical disorder of the guests, we could identify a preferred binding of the acetone via a NH···OC hydrogen bond for the NH2 and the NHCHO anchor groups by analyzing trends in the 13C isotropic chemical shifts. At the same time 1H–1H through-space connectivities reveal a close vicinity of the acetone methyl groups to the benzene rings of the linkers. In contrast, for ethanol and water, the interaction with the anchor groups is too weak to compete with the thermal disorder at room temperature.
Towards Improved Inertial Navigation by Reducing Errors Using Deep Learning Methodology (2022)

Autonomous vehicles make use of an Inertial Navigation System (INS) as part of vehicular sensor fusion in many situations including GPS-denied environments such as dense urban places, multi-level parking structures, and areas with thick tree-coverage. The INS unit incorporates an Inertial Measurement Unit (IMU) to process the linear acceleration and angular velocity data to obtain orientation, position, and velocity information using mechanization equations. In this work, we describe a novel deep-learning-based methodology, using Convolutional Neural Networks (CNN), to reduce errors from MEMS IMU sensors. We develop a CNN-based approach that can learn from the responses of a particular inertial sensor while subject to inherent noise errors and provide near real-time error correction. We implement a time-division method to divide the IMU output data into small step sizes to make the IMU outputs fit the input format of the CNN. We optimize the CNN approach for higher performance and lower complexity that would allow its implementation on ultra-low power hardware such as microcontrollers. Our results show that we achieved up to 32.5% error improvement in straight-path motion and up to 38.69% error improvement in oval motion compared with the ground truth. We examined the performance of our CNN approach under various situations with IMUs of various performance grades, IMUs of the same type but different manufactured batch, and controlled, fixed, and uncontrolled vehicle motion paths.
Highly Efficient Blue OLEDs Based on Metal‐Assisted Delayed Fluorescence Pd(II) Complexes (2019)

Abstract A series of metal‐assisted delayed fluorescence (MADF) palladium(II) complexes, PdN1N, PdN1N‐dm, and PdN6N, are studied. Their 77 K photoluminescence emission spectra show a narrow primary emission peak at 464, 466, and 470 nm, respectively, with small vibronic peaks characteristic of many phosphorescent emitters. At room temperature (300 K), the dominant emission peaks for PdN1N, PdN1N‐dm, and PdN6N are slightly redshifted to 472, 470, and 476 nm, respectively. In the meantime, a broad sideband is also shown between 410 and 450 nm due to the MADF process. A blue device employing PdN1N‐dm demonstrates an electroluminescence emission peak at 476 nm and the maximum external quantum efficiency (EQE) of 25.1%. The high maximum EQE of the blue organic light‐emitting diode (OLED) device indicates that both the phosphorescence and the delayed fluorescence are very efficient. In addition, a stable OLED device of PdN1N‐dm gives a maximum EQE of 9.8% and the estimated operational lifetime LT 70 of 350 h at the practical luminance of 100 cd m −2 .
Synthesis, Cyclopolymerization and Cyclo-Copolymerization of 9-(2-Diallylaminoethyl)adenine and Its Hydrochloride Salt (2012)

We report herein the synthesis and characterization of 9-(2-diallylaminoethyl) adenine. We evaluated two different synthetic routes starting with adenine where the optimal route was achieved through coupling of 9-(2-chloroethyl)adenine with diallylamine. The cyclopolymerization and cyclo-copolymerization of 9-(2-diallylaminoethyl)adenine hydrochloride salt resulted in low molecular weight oligomers in low yields. In contrast, 9-(2-diallylaminoethyl)adenine failed to cyclopolymerize, however, it formed a copolymer with SO₂ in relatively good yields. The molecular weights of the cyclopolymers were around 1,700-6,000 g/mol, as estimated by SEC. The cyclo-copolymer was stable up to 226 °C. To the best of our knowledge, this is the first example of a free-radical cyclo-copolymerization of a neutral alkyldiallylamine derivative with SO₂. These polymers represent a novel class of carbocyclic polynucleotides.
X-ray structural studies of poly(3-alkylthiophenes): an example of an inverse comb (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTX-ray structural studies of poly(3-alkylthiophenes): an example of an inverse combT. J. Prosa, M. J. Winokur, Jeff Moulton, Paul Smith, and A. J. HeegerCite this: Macromolecules 1992, 25, 17, 4364–4372Publication Date (Print):August 1, 1992Publication History Published online1 May 2002Published inissue 1 August 1992https://pubs.acs.org/doi/10.1021/ma00043a019https://doi.org/10.1021/ma00043a019research-articleACS PublicationsRequest reuse permissionsArticle Views4116Altmetric-Citations644LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Breast Reinnervation (2013)

DIEP flap neurotization using the third anterior intercostal nerve is an effective technique to provide a significant increase in sensory recovery for breast reconstruction patients, while adding minimal surgical time. Additionally, the use of a nerve conduit produces increased sensory recovery when compared direct coaptation.
Fiber-to-waveguide coupler based on the parabolic reflector (2008)

We present a fiber-to-waveguide coupling structure, the so-called vertical J coupler, based on the parabolic reflector. The device addresses the multiple objectives of high coupling efficiency, large bandwidth operation, polarization insensitivity, and compact footprint. The optical mode emanating from a fiber arranged normal to the plane of the substrate is incident underneath the parabolic reflector, turned through 90 degrees and focused into a dielectric waveguide. The viability of the coupler is demonstrated by finite-difference time-domain electromagnetic simulation as well as preliminary fabrication and optical testing of the device.
A Vehicle Tracking Device with Built-in Safety Features for Public Transportation Systems (2019)

Automatic Vehicle Location (AVL) devices have become a fundamental part of fleet management in different transport modes. Besides determining the current geographical position, these devices incorporate additional functionalities to monitor vehicles, such as gas consumption, engine temperature, etc. However, critical security vulnerabilities in developing countries have been omitted by manufacturers, causing fleet transportation difficulties. This article presents an analysis of fleet transportation problems from the AVL operation and proposes a set of requirements to mitigate them. A prototype that meets these requirements is presented and tested.
A bijection for loopless triangulations of a polygon with interior points (2002)

Colloque avec actes et comité de lecture. internationale.
Foundry Photonic Process Extension With Bandgap Tuning Using Selective Area Growth (2019)

The extension of a photonic integrated circuit foundry process flow is proposed by integrating selective area growth to enable bandgap tuning for each individual active building block. The process adaptations and the impact on performance are reviewed in terms of morphology requirements and topology reduction. This platform extension enables bandgap tuning for a set of active devices to cover the wavelength range from 1453 to 1651 nm. Integration is demonstrated in combination with active-passive butt-joint technology to create the most comprehensive range of generic building blocks. Performance and limitations of the range of achievable band edges within the same monolithic wafer are studied for amplifiers and extended cavity lasers.
Unscented particle filter based Gaussian process regression for IMU/BDS train integrated positioning (2016)

Aiming at the inaccurate of system dynamic model may reduce the filtering effect, a new Unscented Particle Filter based on improved Gaussian process (GPUPF) is proposed in this paper. The importance density function of UPF is obtained by Gaussian process regression, when the system model and noise are uncertain, GPR is used to revise and estimate the system, determine the covariance matrices of system noises, gets better importance density function, and enhance the adaptive capability of UPF. The improved algorithm was applied to the IMU/BDS train integrated positioning system. Simulation results show that the proposed algorithm is better than standard UPF, leading to improved positioning precision.
Critical role of initial condition in the dynamics of memristive systems: Orbital narrowing revisited (2013)

This paper explores the characterization of memristive systems utilizing the characteristive curve of state and analyze the special role of initial condition in such history-dependent systems. The specifically studied system focuses on the titanium dioxide memristor based on the nonlinear ionic drift model of Joglekar. We derive first the characteristic curve of state (CCOS) as the analytical solution of the model to any integer index in the Gaussian hypergeometric form, based on which a characterization approach is then developed. The approach simply converts the complicated history-dependent dynamics into a mapping on the state-flux phase plane, expressing the initial condition as a pure translation along the flux axis, which is analogous to the characterization method for transistors. With this geometric view, we observe that the initial condition operates as an operation point for a memristive system and can effectively influence the orbital shape: the same input signal can produce two distinct orbital shapes when the initial conditions differ. From another point, there ought to be two factors giving rise to the orbital narrowing phenomenon: the frequency and the initial condition. It is pointed out that this is purely caused by the nonlinearity in the model.
Potato Virus X as a Novel Platform for Potential Biomedical Applications (2009)

We demonstrate that nanoparticles formed from the rod-shaped plant virus Potato virus X (PVX) can serve as a novel platform for biomedical applications. Bioconjugation protocols including amine modification and "click" chemistry allowed the efficient functionalization of PVX with biotins, dyes, and PEGs. Fluorescent-labeled and PEGylated PVX particles revealed that different fluorescent labels have a profound effect on PVX-cell interactions. Applying bioconjugation chemistries to PVX opens the door for chemical functionalization with targeting and therapeutic molecules.
Stem Cells and Tissue Engineering Technologies for Advancing Human Teratogen Screening (2018)

This chapter will cover the use of stem cells and tissue engineering technologies in the assessment of developmental and reproductive toxicity (DART). We will first give an overview of current animal-based DART regulatory guidelines to highlight opportunities where in vitro assays can replace or complement animal testing in the identification of potential teratogens. To date, animal embryo-based in vitro assays, such as rat whole embryo culture (WEC), zebrafish and chicken embryo models, have been explored as animal alternatives for teratogen testing. We will briefly summarize salient features of these in vitro embryo culture systems and discuss recent technological advances, such as the use of microfluidic platforms to facilitate improvements in assay robustness and throughput. More recently, pluripotent stem-cell (PSC)-based assays for teratogen screening are increasingly being developed because they can potentially be human-specific via the use of human PSCs. Moreover, PSC-based models allow one to probe and measure teratogenic effects through multiple readouts, including changes in molecular biomarker expression, metabolite profiles, as well as cellular differentiation and migration phenotypes. The adoption of tissue engineering approaches to control PSC differentiation rates into various tissue types will allow for more realistic modeling of embryonic developmental processes to screen for potential teratogens with higher throughput and precision.
‘Orwell’: a protocol for carrying integrated services on a digital communications ring (1984)

A new protocol is described, capable of carrying mixed telecommunications services on a high-speed slotted ring. An inherent overload control mechanism ensures that delays to time-critical services are bounded and synchronous transmissions are preserved until their natural cessation. By over-coming objections to the destination release of slots, ring capacity is significantly increased.
A new scheme for direct sequence spread spectrum radio LANs (2002)

A new direct sequence spread spectrum scheme for ISM band radio local area networks using BPSK modulation and matched filter receivers is presented. It employs an optimised 22-chip sequence whose two 11-chip segments are alternately used as spreading sequences for adjacent symbols. Owing to the low cross-correlation between the two 11-chip segments, the inter-symbol interference caused by long delays in multipath channels is significantly reduced. In the paper, a receiver structure using the optimised sequence and time diversity is described and simulation results are given. Compared with the schemes using the short 11-chip Barker code and long M-sequences, the new scheme offers superior system performance.
Phevor Combines Multiple Biomedical Ontologies for Accurate Identification of Disease-Causing Alleles in Single Individuals and Small Nuclear Families (2014)

Phevor integrates phenotype, gene function, and disease information with personal genomic data for improved power to identify disease-causing alleles. Phevor works by combining knowledge resident in multiple biomedical ontologies with the outputs of variant-prioritization tools. It does so by using an algorithm that propagates information across and between ontologies. This process enables Phevor to accurately reprioritize potentially damaging alleles identified by variant-prioritization tools in light of gene function, disease, and phenotype knowledge. Phevor is especially useful for single-exome and family-trio-based diagnostic analyses, the most commonly occurring clinical scenarios and ones for which existing personal genome diagnostic tools are most inaccurate and underpowered. Here, we present a series of benchmark analyses illustrating Phevor's performance characteristics. Also presented are three recent Utah Genome Project case studies in which Phevor was used to identify disease-causing alleles. Collectively, these results show that Phevor improves diagnostic accuracy not only for individuals presenting with established disease phenotypes but also for those with previously undescribed and atypical disease presentations. Importantly, Phevor is not limited to known diseases or known disease-causing alleles. As we demonstrate, Phevor can also use latent information in ontologies to discover genes and disease-causing alleles not previously associated with disease.
PDoT (2021)

Security and privacy of the Internet Domain Name System (DNS) have been longstanding concerns. Recently, there is a trend to protect DNS traffic using Transport Layer Security (TLS). However, at least two major issues remain: (1) How do clients authenticate DNS-over-TLS endpoints in a scalable and extensible manner? and (2) How can clients trust endpoints to behave as expected? In this article, we propose a novel Private DNS-over-TLS (PDoT) architecture. PDoT includes a DNS Recursive Resolver (RecRes) that operates within a Trusted Execution Environment. Using Remote Attestation , DNS clients can authenticate and receive strong assurance of trustworthiness of PDoT RecRes. We provide an open source proof-of-concept implementation of PDoT and experimentally demonstrate that its latency and throughput match that of the popular Unbound DNS-over-TLS resolver.
Effects of motion and configural complexity on color transparency perception (2006)

We tested whether motion and configural complexity affect perceived transparency. A series of five coherent chromatic transformations in color space was applied across a figure: translation, convergence, shear, divergence and rotation. The stimuli consisted of a bipartite or a checkerboard configuration (10 x 10 degrees), with a central static or moving overlay (5 x 5 degrees). Three different luminance conditions (the plane of chromatic transformation oriented toward higher, lower, or equal luminances) were also tested for each of three modulation depths. For each stimulus, the observer judged whether the overlay appeared transparent or not. The main results indicated an interaction between the type of chromatic transformation and stimulus motion and complexity. For example, convergences are judged to appear transparent significantly more often when motion is added for bipartite configurations, or when they are generated in a checkerboard configuration. Surprisingly, shears that have been reported to appear opaque, are more frequently reported to appear transparent with short vector lengths and when combined with motion. Other transformations are also affected by motion, although the effectiveness of figural complexity on transparency seems to depend on both the type of color shifts and the presence of motion. The results indicate that adding motion and stimulus complexity are not necessarily neutral with respect to the chromatic shifts evoking transparency. Thus, studies that have used motion to enhance transparency may yield different results about the color shifts supporting transparency perception from those that did not. The same might be supposed for stimulus complexity under some conditions.
The effect of different air-polishing powders on dentin bonding. (2007)

Calcium carbonate air polishing should be avoided when dentin-bonded restorations are applied. Glycine powder is an alternative.