gebhart/patrepeval huggingface dataset:
The implementation of knowledge-based recommender system for electronic commerce using Java expert system library (2002)

This paper deals the design and implementation of product recommender system on a Internet shopping mall. In e-commerce application, sometimes potential buyers may be interested in receiving recommendations about what to purchase. The mainstream of an automated recommender system is collaborative filtering. In this paper, we present a knowledge-based product recommender system. The knowledge base of product domain and inference engine is implemented by JESS (Java expert system shell) and Java servlet. The system gathers the user's requirements on a particular product by questioning the user and consulting its knowledge base to find the items that best meet the user's requirement. For the recommender system, the design of product knowledge base are discussed. As a sample implementation, a cellular phone recommender system is built where the system tries to find a phone model that best meets the user's requirements.
Reduction of ADAMTS13 Levels Predicts Mortality in SARS-CoV-2 Patients (2020)

In SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infected patients, hemostasis shows an uncontrolled activation, with a high D-dimer concentration.[1] [2] It has been also shown that the SARS-CoV-2 can promote endotheliitis,[3] and in turn, pulmonary endothelial damage fostering thrombogenesis.[4]
The development of dermal lesions and alopecia in male rats fed rapeseed oil (1976)

For 8 weeks 10 male weanling Sprague-Dawley rats were fed a semisynthetic diet containing by weight either 20% corn oil or rapeseed oils containing different amounts of erucic acid (Brassica napus var. Zephyr, 0.6%; B. napus var. Oro, 1.8%; B. campestris var. Span, 4.8%; or B. campestris var. Echo and Arlo, i.e., regular rapeseed oil, 23.6%). At 4-5 weeks after the experiment began, rats receiving the diets containing rapeseed oil showed evidence of alopecia and developed scaly, hemorrhagic, and necrotic tails, as well as scaliness of the feet, similar to the lesions described in essential fatty acid (EFA) deficiency. This condition became most severe between 5 and 8 weeks and had disappeared by 14 weeks. Fatty acid analysis of the diets and tissues of the animals did not reveal any evidence of EFA deficiency. It is suggested that these symptoms observed might be related to a possible inhibition of prostaglandin biosynthesis in rats fed rapeseed oils.
Studies with Reissert compounds. Part 17. Mono-Reissert compound formation at the 1,2-position of the quinazoline system (1986)

4-Substituted quinazolines have been selectively converted into mono-Reissert compounds at the 1,2-position by use of acid chlorides and trimethylsilyl cyanide. Various reactions of the quinazoline Reissert compounds are reported. For example, conjugate base generation at the 2-position leads to a 1,2-rearrangement, whereas substitution occurs in the presence of an alkyl halide, providing, after hydrolysis, 2-alkyl-4-phenylquinazolines in good yield. Ring annellation by intramolecular alkylation is also reported. The quinazoline Reissert compound conjugate base reacts with aldehydes to give alcohol esters which can further be converted, via the alcohol and use of phosgene, to novel oxazolo[4,3-a]quinazoline derivatives.
Robust synthesis of yttria stabilized tetragonal zirconia powders using a semi-continuous process in supercritical CO2 (2013)

International audience
Infrared Spectrum of Two Fullerene Derivatives: C60O and C61H2 (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInfrared Spectrum of Two Fullerene Derivatives: C60O and C61H2Gianni Cardini, Roberto Bini, Pier R. Salvi, Vincenzo Schettino, Michael L. Klein, Robert M. Strongin, Laurent Brard, and Amos B. Smith IIICite this: J. Phys. Chem. 1994, 98, 40, 9966–9971Publication Date (Print):October 1, 1994Publication History Published online1 May 2002Published inissue 1 October 1994https://pubs.acs.org/doi/10.1021/j100091a006https://doi.org/10.1021/j100091a006research-articleACS PublicationsRequest reuse permissionsArticle Views308Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Dose-Finding and Pharmacokinetic Study of Cisplatin, Gemcitabine, and SU5416 in Patients With Solid Tumors (2002)

PURPOSE: To investigate the feasibility and pharmacokinetics of the combination cisplatin, gemcitabine, and SU5416. PATIENTS AND METHODS: Patients received cisplatin 80 mg/m 2 on day 1, gemcitabine 1,250 mg/m 2 on days 1 and 8, repeated every 3 weeks, and SU5416 (85 and 145 mg/m 2 ) intravenously twice weekly. Pharmacokinetics of all three agents, side effects, and antitumor response were investigated in patients with solid tumors amenable to therapy with cisplatin/gemcitabine. RESULTS: In the first cohort of three patients entered at the 85 mg/m 2 dose, no dose-limiting toxicities were observed. In the next cohort (145 mg/m 2 ), three patients developed a thromboembolic event. After entry was restricted to patients with low thromboembolic risk, three additional patients enrolled at 145 mg/m 2 developed a thromboembolic event. The dose was then reduced to 85 mg/m 2 in all patients still on the study, and three additional patients were entered on this dose level. In 19 treated patients, eight patients developed nine thromboembolic events (three transient ischemic attacks, two cerebrovascular accidents, and four deep venous thromboses). The most common toxicities observed were those previously reported for SU5416 alone (headache and phlebitis) and for this chemotherapy regimen (nausea, thrombocytopenia, and leucopenia). No significant pharmacologic interaction among the three drugs was observed. Response rates were similar to those expected in the patient population selected for this study. Analysis of variables of the coagulation cascade and of vessel wall activation was performed in three patients and showed significant increases in thrombin generation and endothelial cell perturbation in a treatment cycle–dependent manner. CONCLUSION: The incidence of thromboembolic events, possibly related to the particular regimen tested in this study, discourages further investigation of this regimen.
Hybrid magnetic composite (HMC) materials for sensor applications (2016)

Several applications adopt electromagnetic sensors, that base their principle on the presence of magnets realized with specific magnetic materials that show a rather high remanence, but low coercivity. This work concerns the production, analysis and characterization of hybrid composite materials, with the use of metal powders, which aim to reach those specific properties. In order to obtain the best coercivity and remanence characteristics various "recipes" have been used with different percentages of soft and hard magnetic materials, bonded together by a plastic binder. The goal was to find out the interdependence between the magnetic powder composition and the characteristics of the final material. Soft magnetic material (special Fe powder) has been used to obtain a low coercivity value, while hard materials were primarily used for maintaining a good induction remanence; by increasing the soft proportion a higher magnetic permeability has been also obtained. All the selected materials have been characterized and then tested; in order to verify the validity of the proposed materials two practical tests have been performed. Special magnets have been realized for a comparison with original ones (AlNiCo and ferrite) for two experimental cases: the first is consisting in an encoder realized through a toothed wheel, the second regards the special system used for the electric guitars.
Design, synthesis and biological evaluation of novel lipid-based nanoparticle delivery system for metabolic re-engineering (2013)

Dietary supplementation with fibre has been shown to ameliorate features of the metabolic syndrome and inhibit malignant growth in certain types of cancer. These effects have been linked to short-chain fatty acids (SCFA), mostly acetate. However, the ubiquitous role of SCFAs in metabolism, combined with a short tissue half-life and the non-targeted nature of oral and peripheral administrations make achieving phenotypically relevant levels of SCFA by standard delivery techniques challenging and limit their therapeutic potential. Liposomal encapsulation of a therapeutic agent overcomes these issues by protecting against degradation, increasing circulation time and passively targeting both the liver and tumour tissue. In this research project, I have designed a bifunctional liposome formulation to transport SCFA, monitored their distribution and uptake utilising visualisation by MRI, PET/CT and fluorescence microscopy. These bifunctional liposomes were useful for effectively encapsulating small molecules within their aqueous core, which in this case was acetate, and capable of acetate delivery into cells while also being amenable to cellular imaging. I have shown that preferential delivery of liposome encapsulated acetate (LITA) nanoparticles to key sites of metabolic control provide beneficial therapeutic effects in animal models of both obesity and cancer. Chronic administration of LITA nanoparticles in an obeseogenic model led to a significant reduction in adiposity, intrahepatocellular lipid, inflammatory tone and genetic indication of a decrease fatty acid synthesis in the liver. Application of LITA in a murine xenograft model caused an inhibition of tumour growth in three colorectal cancer cell lines: HT-29, HCT116 p53+/+ and HCT116 p53-/-. The mechanisms for these two outcomes are not fully defined; however cellular energy homeostasis of both scenarios was restored. These results indicate that LITA nanoparticles can be used to improve multiple metabolic pathways, in vivo.
Study on a Disaster Recovery Network Mechanism by Using Widely Distributed Client Nodes (2009)

An innovative mechanism of a file-backup system concept is proposed. In the proposed file backup mechanism, the combination of the following technologies such as a spatial random scrambling of file data, a subsequent random fragmentation of the file, the corresponding encryption and duplication for each fragmented one by using a stream cipher code in each encryption stage, and the corresponding notification of the history data of the used encryption key code sequence of "encryption metadata" in addition can effectively realize the highly secure and prompt file backup system only when they are combined at the same time. In case of disaster occurrences in data backup center, the prompt data recovery can be easily and securely achieved by making use of a widely distributed huge amount of wired PCs or mobile PCs, mobile phones, and PDAs via several supervisory servers which are secretly diversified and functionally combined mutually. This paper also proposes the network architecture which can realize user-friendly service level control mechanism using RFID. The experimental evaluation of the average response time from the Web server has been estimated in terms the memory load characteristics of the data center.
Edible acetylated monoglyceride films: Effect of film‐forming technique on moisture barrier properties (2004)

Abstract The influence of film‐forming techniques on the moisture barrier efficiency of acetylated MG (AMG) films tested in real conditions at the interface between an agar gel (AG) and sponge cake (SC) was investigated. Three systems were studied: self‐supporting films, sprayed films, and cast films. The moisture distribution profiles of the AG/AMG/SC systems were determined experimentally and by using a predictive model for both self‐supporting films of various thicknesses and formed‐in‐place (sprayed or cast) films. Increasing the thickness of the self‐supporting films had no influence on moisture barrier efficiency, probably due to the high stability of the AMG material. Formed‐in‐place films were 40% less efficient than the self‐supporting films whatever the application procedure used (spraying or casting) because of their poor integrity due to the roughness of the SC surface.
Antioxidative Effects of Probucol and Changes in the Concentrations of <i>in vivo</i> Antioxidants Following an Oral Administration of Probucol (1994)

We investigated the in vitro effects of probucol on the oxidation of isolated low density lipoprotein (LDL) and of plasma by cupric ions. We also studied changes in the concentrations of lipid peroxides and antioxidants in circulating blood following the oral administration of probucol.(1) LDLs were dose-dependently oxidized in vitro by cupric ions. The oxidation of LDL by cupric ions was markedly enhanced in the presence of monocytes. Probucol markedly inhibited the oxidation of LDL. The antioxidant effects of probucol were more marked in the presence of cupric ions. On the other hand, plasma was only very slightly, if at all, oxidized by cupric ions in vitro, and the antioxidant effects of probucol were not clear. It was suggested that the antioxidants in plasma (particularly, vitamin C) and/or plasma protein protected plasma lipids from oxidation by cupric ions.(2) After 500mg probucol were administered daily for two weeks, the thiobarbituric acid reactive substances of plasma decreased significantly, although the hydroperoxide of the plasma lipids remained unchanged.(3) An increase in the plasma ubiquinol-10/ubiquinone-10 ratio was observed after the oral administration of probucol, suggesting some protective effects of probucol on ubiquinol-10 which is regarded as a natural antioxidant in vitro.
Elimination of Corrosion and Stress Corrosion Cracking Risks in a Carbon Steel and in a Stainless Steel Digester (2012)

Abstract Digester corrosion has become a major topic for the pulp and paper industry in that it brought about the need for high expenditures with repairs, replacement of components and upgrade of materials, as well as losses in connection with unplanned outages. Risks to life and property are also significant, as catastrophic failure of pressurized equipment may result. From the eighties to present day, corrosion problems in many pulp and paper mills around the world have been intensifying, for reasons ranging from materials and design aspects of the digesters themselves, to process modifications introduced ever since. The present work has the main objective to study the corrosive behavior of continuous digesters with modified processes. Actual corrosion cases in two digesters are presented: (i) carbon steel and (ii) stainless steel clad (316L) digester. Electrochemical testing, metallurgical analyses, corrosion testing and field inspections were used to support the discussions and conclusions. In one field case, a carbon steel digester experienced rapid thinning on its top sections with wall loss of 5 mm over 30 months, after a process change. In the second case, also following a process change, a type 316L stainless-clad continuous digester, the only one in such material known in the Kraft pulping, presented an altered electrochemical profile indicating prospective stress corrosion cracking risk. This prompted the execution of studies and protective measures that are unique for stainless cooking vessels. The risks to carbon or austenitic stainless steel digesters running on modern cooking processes are demonstrated to be significant. The effectiveness of the protective technologies, as well as their compatibility, was proved. The need to consider these technologies upon cooking retrofit projects was established.
Complexes between kinases, mitochondrial porin and adenylate translocator in rat brain resemble the permeability transition pore (1996)

In vitro incubation of isolated hexokinase isozyme I or isolated dimer of mitochondrial creatine kinase with the outer mitochondrial membrane pore led to high molecular weight complexes of enzyme oligomers. Similar complexes of hexokinase and mitochondrial creatine kinase could be extracted by 0.5% Triton X-100 from homogenates of rat brain. Hexokinase and creatine kinase complexes could be separated by subsequent chromatography on DEAE anion exchanger. The molecular weight, as determined by gel-permeation chromatography, was approximately 400 kDa for both complexes. The Mr suggested tetramers of hexokinase (monomer 100 kDa) and creatine kinase (active enzyme is a dimer of 80 kDa). The composition of the complexes was further characterised by specific antibodies. Besides either hexokinase or creatine kinase molecules the complexes contained porin and adenylate translocator. It was possible to incorporate the complexes into artificial bilayer membranes and to measure conductance in 1 M KCI. The incorporating channels had a high conductance of 6 nS that was asymmetrically voltage dependent. The complexes were also reconstituted in phospholipid vesicles that were loaded with ATP. Complex containing vesicles retained ATP while vesicles reconstituted with pure porin were leaky. The internal ATP could be used by creatine kinase and hexokinase in the complex to phosphorylate external creatine or glucose. This process was inhibited by atractyloside. The hexokinase complex containing vesicles were furthermore loaded with malate or ATP that was gradually released by addition of Ca2+ between 100 and 600 microM. The liberation of malate or ATP by Ca2+ could be inhibited by N-methylVal-4-cyclosporin, suggesting that the porin translocator complex constitutes the permeability transition pore. The results show the physiological existence of kinase porin translocator complexes at the mitochondrial surface. It is assumed that such complexes between inner and outer membrane components are the molecular basis of contact sites observed by electron microscopy. Kinase complex formation may serve three regulatory functions, firstly regulation of the kinase activity, secondly stimulation of oxidative phosphorylation and thirdly regulation of the permeability transition pore.
Role of phosphorylation of Thr residue of phospholamban in mechanical recovery during hypercapnic acidosis (2005)

CaMKII-dependent Thr(17) phosphorylation significantly increased at the beginning of acidosis, is responsible for 50% of the early relaxation recovery, and is linked to the activation of the reverse Na(+)/Ca(2+) mode. The early contractile recovery and the late mechanical recovery are dependent on CaMKII but independent of the phosphorylation of the Thr(17) residue of phospholamban. The reverse Na(+)/Ca(2+) mode has an additional negative effect that opposes the early mechanical recovery.
Novel 3-Azaindolyl-4-arylmaleimides Exhibiting Potent Antiangiogenic Efficacy, Protein Kinase Inhibition, and Antiproliferative Activity (2012)

Tumor growth and metastasis are highly associated with the overexpression of protein kinases (PKs) regulating cell growth, apoptosis resistance, and prolonged cell survival. This study describes novel azaindolyl-maleimides with significant inhibition of PKs, such as VEGFR, FLT-3, and GSK-3β which are related to carcinogenesis. Furthermore, these compounds exhibit high kinase selectivity and potent inhibition of angiogenesis and cell proliferation, offering versatile options in cancer treatment strategies.
Prospective Study of Fatty Acid Supplementation Over 3 Years in Patients with Cystic Fibrosis (1983)

Intravenous fatty acid supplementation (10% Intralipid, 10 ml/kg body weight) was given to 10 patients with cystic fibrosis (CF), in intervals for 3 years. One year of intensive treatment with supplementation every fortnight was followed by 1 year of intermission and then 1 year of the same treatment given for 2 days every 2 months. Compared with matched CF patients, the clinical course, evaluated by Shwachmann scoring, showed less deterioration in the treated group, especially during the year of intensive treatment. Single parameters, such as pulmonary function tests, pulmonary X-ray films, clinical infections, bacterial growth of sputa, and sweat electrolyte concentration, showed no differences. It is concluded that if there is any benefit of this kind of treatment in CF, it has to be very intensive. At present, the psychological stress involved in repeated parenteral administrations over long periods prevents its use in clinical routine.
New yeast isolate Pichia caribbica synthesizes xylolipid biosurfactant with enhanced functionality (2014)

Sophorolipids (SL) belong to a class of glycolipidic biosurfactants suitable for a wide range of applications. The structural diversity in SL gives rise to variation in physicochemical and biological properties. To achieve the less explored head group diversity in sophorolipid structure, a new xylose fermenting yeast Pichia caribbica has been employed for biosurfactant production. The media and fermentation parameters have been optimized to achieve maximum yield of 7.48 g/L. The physicochemical properties of the xylolipid biosurfactant have been assessed. It reduced the surface tension of distilled water from 70 to 35.9 mN/m with the low critical micellar concentration (CMC) 1.0 mg/L as compared to typical SL (reported CMC range 40–100 mg/L). Structural characterization was done using FTIR and HR‐MS to identify the structure. 17‐ L ‐[(β‐ D ‐xylopyranosyl)‐oxy]‐Δ9‐heptadecanoic acid correlated to m / z 415 majorly constituted the product. Control experiment was performed in which glucose was provided as the hydrophilic carbon. This product was also subjected to HR‐MS analysis to determine its chemical nature and found to be different from xylolipid. Presence of xylose as head group was anticipated to give altered physicochemical and biological activities and indeed a low CMC value and better inhibitory action was demonstrated against Staphylococcus aureus . Practical applications: Sophorolipids produced by microbial sources have several advantageous properties over commercial petroleum‐based surfactants including biodegradability, environmentally friendly nature, and low toxicity. Here, we have attempted to modify the hydrophilic head group by incorporating xylose in place of glucose. This molecule will also behave differently in response to different stimuli. Stimuli‐responsive surfactants are a class of compounds with applications in stabilization of emulsions, suspensions or foams, drug encapsulation and delivery, hard‐surface cleaning, personal care applications. New yeast isolate – Pichia caribbica was provided with xylose and oleic acid. This resulted in synthesis of glycolipidic molecule different from typical sophorolipid synthesized by Candida bombicola . Xylose was incorporated as head group, i.e., hydrophilic moiety in place of glucose. The variation in structure imparted better surface tension lowering activity thus showed low CMC value. Also antibacterial activity was enhanced.