gebhart/patrepeval huggingface dataset:
Co-publication withJournal of Physics D: Applied Physics (2011)

This is a co-publication with Journal of Physics D: Applied Physics. The bulk of the papers, after peer review, are published in Journal of Physics: Conference Series. However a selection of papers, are published separately in a special issue of Journal of Physics D: Applied Physics.
Shielding stray magnetic fields of open high field MRI magnets (2004)

We have developed a new magnet for open high field (0.7 T) MRI systems. Since MRI systems are installed in hospital sites, it is important to reduce stray magnetic fields of the magnets. We studied passive, active and hybrid shielding methods and compared them. In order to study feasibility of active shielding, we considered higher order multipole stray fields. We present details of the calculation method and the results.
Research on pressure‐stabilizing system for transfer device for natural gas hydrate cores (2019)

Abstract To broaden the analysis means for natural gas hydrate (NGH)‐pressured cores, long‐columnar cores are usually cut into smaller segments with a pressure‐retaining transfer device for NGH. The pressure‐stabilizing system is the core part of a transfer device for NGH, providing a stable high‐pressure environment for the transfer process to avoid NGH decomposition. In this study, the characteristics of the pressure‐stabilizing system were thoroughly studied, and the factors affecting the pressure fluctuations in the transfer device were discussed. Accordingly, the pressure‐stabilizing system was modeled with AMESim software, and the model parameters were set according to the actual working conditions. The simulated pressure fluctuations in the transfer process of transfer device for NGH confirm the theoretical results, which indicate that the precharge pressure of the accumulator should be 0.8‐0.9 times the working pressure. In addition, an increased accumulator volume decelerates the response of the system. Experiments were conducted to test the reliability of the pressure‐stabilizing system. During the transfer process of the NGH sample, the operating pressure can reach 20 MPa, and the fluctuations of the inner pressure are below 20%.
Scale invariance in biology: coincidence or footprint of a universal mechanism? (2001)

In this article, we present a self-contained review of recent work on complex biological systems which exhibit no characteristic scale. This property can manifest itself with fractals (spatial scale invariance), flicker noise or 1/f-noise where f denotes the frequency of a signal (temporal scale invariance) and power laws (scale invariance in the size and duration of events in the dynamics of the system). A hypothesis recently put forward to explain these scale-free phenomomena is criticality, a notion introduced by physicists while studying phase transitions in materials, where systems spontaneously arrange themselves in an unstable manner similar, for instance, to a row of dominoes. Here, we review in a critical manner work which investigates to what extent this idea can be generalized to biology. More precisely, we start with a brief introduction to the concepts of absence of characteristic scale (power-law distributions, fractals and 1/f-noise) and of critical phenomena. We then review typical mathematical models exhibiting such properties: edge of chaos, cellular automata and self-organized critical models. These notions are then brought together to see to what extent they can account for the scale invariance observed in ecology, evolution of species, type III epidemics and some aspects of the central nervous system. This article also discusses how the notion of scale invariance can give important insights into the workings of biological systems.
Molecular phenotypes of human parvovirus B19 in patients with myocarditis (2014)

The finding of significantly increased B19V loads in patients with histologically proven cardiac inflammation suggests a crucial role of B19V-genotypes and reactivation of B19V-infection by HHV6-coinfection in B19V-associated iCMP. Our findings suggest that B19V-infection of the human heart can be a causative event for the development of an endothelial cell-mediated inflammatory disease and that this is related to both viral load and genotype.
Bayesian optimization with known experimental and design constraints for chemistry applications (2022)

A Bayesian optimization algorithm that satisfies known constraints has been developed. The usefulness of considering experimental and design constraints are shown in two simulated chemistry applications.
Prevalence and prognostic value of cirrhotic cardiomyopathy as defined according to the proposed new classification (2021)

Aim of the study: Prevalence and prognostic relevance of cirrhotic cardiomyopathy (CCM), as defined according to the new core criteria proposed in 2019, are still unknown. We investigated this relevant issue in a large cohort of cirrhotic patients.
Records of celtic occupation in local names (7th S. Iv. 1, 90, 134, 170, 249; V. 9): wales, yorkshire (7th S. V. 328, 478) (1888)

Journal Article Records of celtic occupation in local names (7th S. Iv. 1, 90, 134, 170, 249; V. 9): wales, yorkshire (7th S. V. 328, 478) Get access Geo. Neilson Geo. Neilson Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s7-VI, Issue 134, 21 July 1888, Pages 52–53, https://doi.org/10.1093/nq/s7-VI.134.52e Published: 21 July 1888
Measurement of intracellular pH: differences between microspectrofluorimetric and imaging systems (2006)

Background. Since 1979, more than a thousand papers have reported the use of biscarboxyethylcarboxyfluorescein (BCECF) for making measurement of intracellular pH (pHi) using microspectrofluorimetric systems (MSFS). Looking critically at these papers, some odd and unexplained things can be observed. For example, there are big differences in the resting pHi of the cells, even in similar cells, in similar conditions and described in the same paper. Despite the huge development of imaging systems (IS), only few imaging measurements can be found in the literature to monitor real-time changes of pHi. Our aim was to compare MSFS (LIFE SCIENCES) and IS (OLYMPUS CellR).
Waterjet as a multimode waveguide-theoretical and experimental investigation of modal noise and beam propagation in material processing with lasermicrojet (2006)

Waterjets can be used as light waveguides due to the total internal reflection at the water-air interface. As the diameter of the jet is large compared to the laser wavelength, the jet is comparable to a multimode fiber. In this article the propagation and the intensity distribution of a laser beam coupled in a laminar waterjet at various coupling conditions such as jet diameter, velocity and jet length as well as beam numerical aperture and beam position from jet center is studied. The intensity distributions are also compared with the structures resulting from high power material ablation using the Laser MicroJet (LMJ) technology.
Hypoventilation und arterielle Hypotonie bei Bronchoskopien unter tiefer Sedierung mit Propofol (2011)

Bronchoskopien werden häufig ohne Tubus in Lokalanästhesie am gering sedierten Patienten durchgeführt. Invasivität ist dadurch eingeschränkt möglich und die subjektive Beeinträchtigung des Patienten ist bedeutsam. Die Durchführung von Bronchoskopien am analgosedierten und relaxierten Patienten in starrer Technik erlaubt Invasivität bei Patientensicherheit und -komfort, erfordert aber einen höheren Aufwand. Eine Alternative ist die flexible Bronchoskopie am intubierten Patienten unter tiefer Sedierung mit Propofol.
Function of Metallothionein-3 in Neuronal Cells: Do Metal Ions Alter Expression Levels of MT3? (2017)

A study of factors proposed to affect metallothionein-3 (MT3) function was carried out to elucidate the opaque role MT3 plays in human metalloneurochemistry. Gene expression of Mt2 and Mt3 was examined in tissues extracted from the dentate gyrus of mouse brains and in human neuronal cell cultures. The whole-genome gene expression analysis identified significant variations in the mRNA levels of genes associated with zinc homeostasis, including Mt2 and Mt3. Mt3 was found to be the most differentially expressed gene in the identified groups, pointing to the existence of a factor, not yet identified, that differentially controls Mt3 expression. To examine the expression of the human metallothioneins in neurons, mRNA levels of MT3 and MT2 were compared in BE(2)C and SH-SY5Y cell cultures treated with lead, zinc, cobalt, and lithium. MT2 was highly upregulated by Zn2+ in both cell cultures, while MT3 was not affected, and no other metal had an effect on either MT2 or MT3.
Three-state switching in a double-pole change-over nanoswitch controlled by redox-dependent self-sorting (2019)

The four-arm nanomechanical switch 1 with four different terminals exhibits two switching arms (contacts A and D) and two distinct stations for binding (contacts B and C). In switching State I, the azaterpyridine arm is intramolecularly coordinated to a zinc(ii) porphyrin station (connection A ↔ B) while contact D (a ferrocenylbipyridine unit) and contact C (phenanthroline) remain disconnected. After addition of copper(i) ions (State II) both connections A ↔ B and C ↔ D are established. Upon one-electron oxidation, double-pole change-over switching cleaves both connections A ↔ B & C ↔ D and establishes the new connection A ↔ C (State III). Fully reversible three-state switching (State I → State II → State III → State II → State I) was achieved by adding appropriate chemical and redox stimuli.
The role of micro-inflammation in the pathogenesis of uraemic pruritus in haemodialysis patients (2005)

These results point to a central role of inflammation in the pathogenesis of UP in HD patients.
Acousto-optic interaction in an InI single crystal (2017)

The acousto-optic figure of merit M 2 of the InI single crystal has been measured using the Dixon method at a laser-radiation wavelength of 1.15 μm. The maximum measured value was M 2 = 1100 × 10–15 s3/kg. It is comparable with the figures of merit of the most efficient acousto-optic materials: TeO2 and KRS-5. The velocities of longitudinal ultrasonic waves along the basic directions of the InI single crystal have also been measured.
Nanojoint Formation between Ceramic Titanate Nanowires and Spot Melting of Metal Nanowires with Electron Beam (2017)

Construction of nanoarchitectures requires techniques like joint formation and trimming. For ceramic materials, however, it is extremely difficult to form nanojoints by conventional methods like merging. In this work, we demonstrate that ceramic titanate nanowires (NWs) can be joined by spot melting under electron beam (e-beam) irradiation (EBI). The irradiation fuses the contacted spot of titanate NWs yielding an intact nanojoint. Nanojoints with different morphologies can be produced. The joint structures consist of titanium dioxide (TiO<sub>2</sub>) rutile, anatase, and titanate phases in the direction away from the e-beam melting spot. The titanate binds to anatase via a crystallographic matching coherent interface (the oxygen atoms at the interface are shared by the two phases) and the anatase solidly binds to the rutile joint. The resulting rutile joint is stable at high temperatures. Additionally, it is demonstrated that the heat production from EBI treated rutile can be utilized to break metal NWs (Ag, Cu, and Ni) apart by spot melting. The required e-beam intensity is considerably mild (75 pA/cm<sup>2</sup>) which allows visual access and control over the NW melting. Direct melting of Ag and Cu is not applicable under EBI due to their high thermal conductivity even with high current density (500 pA/cm<sup>2</sup>). Our findings reveal that ceramic nanojoint formation and spot melting at nanoscale are applicable if the properties of nanomaterials are understood and properly utilized.
Fluorescence-Based Peptide Labeling and Fractionation Strategies for Analysis of Cysteine-Containing Peptides (2005)

This study demonstrates that 1,5-I-AEDANS (5-({2-[(iodoacetyl)amino]ethyl}amino)naphthalene-1-sulfonic acid) can be used as a versatile fluorescence-based peptide quantification tool and provides readily interpretable tandem mass spectra for de novo peptide sequencing. Two AEDANS-cysteinyl-peptide fractionation strategies were evaluated. One AEDANS-cysteinyl-peptide fractionation strategy employs immobilized metal affinity chromatography (IMAC) to recover AEDANS-labeled peptides and reduce the complexity of peptide mixtures. In an alternate solid-phase approach, 1,5-I-AEDANS was coupled to an o-nitrobenzyl-based photocleavable resin to produce a resin that can label and isolate thiols and cysteine-containing peptides with a modified-AEDANS label (mAEDANS: 5-((4-amino-4-oxobutanoyl){2-[(iodoacetyl)amino]ethyl}amino)naphthalene-1-sulfonic acid). This fractionation protocol enriches cysteine-containing peptides more specifically than the IMAC strategy. Using micro-LC-ESI-MS with an on-line fluorescence detector and a Q-TOF mass spectrometer, we generated fluorescence-based elution profiles and corresponding positive ion mass spectra of AEDANS-labeled peptides. This study demonstrates that AEDANS-peptides produce positive ion ESI-MS mass spectra with detection limits comparable to those of the unlabeled peptide. Collision-induced dissociation (CID) of fluorescent AEDANS-peptides revealed readily interpretable product ion spectra with the label intact. Similar to the AEDANS-labeled peptide, an mAEDANS-labeled thiol is fluorescent and CID of a mAEDANS-labeled peptide also reveals an interpretable product ion spectrum with the label intact.
Epidermal G rowth F actor R eceptor i n N on-Small-Cell L ung Carcinomas: C orrelation B etween G ene C opy N umber a nd Protein E xpression a nd I mpact o n P rognosis (2003)

Purpose: The epidermal growth factor receptor (EGFR) is frequently overexpressed in non–small-cell lung carcinoma (NSCLC), and EGFR inhibitors are promising new therapeutic agents. The molecular mechanisms responsible for EGFR overexpression are poorly understood. Materials and Methods: Gene copy number and protein status of EGFR were investigated in microarrayed tumors from 183 NSCLC patients, including squamous cell carcinoma (SCC; 89 patients) and non-SCC (94 patients) histologies. Protein expression was assessed by immunohistochemistry on a scale from 0 to 400 (percentage of positive cells staining intensity). Gene and chromosome 7 copy numbers were identified by fluorescent in situ hybridization (FISH). Results: EGFR protein overexpression was observed in 62% of the NSCLC (25% scored 201 to 300; 37% scored 301 to 400), more frequently in SCC than non-SCC (82% v 44%; P < .001), and in 80% of the bronchioloalveolar carcinomas. The prevalent FISH patterns were balanced disomy (40%) and trisomy (38%) for EGFR gene and chromosome 7 (40%), whereas balanced polysomy was seen in 13% and gene amplification was seen in 9% of the patients. Gene copy number correlated with protein expression (r 0.4; P < .001). EGFR overexpression or high gene copy numbers had no significant influence on prognosis. Conclusion: EGFR overexpression is frequent in NSCLC, is most prominent in SCC, and correlates with increased gene copy number per cell. High gene copy numbers per cell showed a trend toward poor prognosis. It will be important to evaluate EGFR gene and EGFR protein status and signal protein expression to properly interpret future clinical trials using EGFR inhibitors. J Clin Oncol 21:3798-3807. © 2003 by American Society of Clinical Oncology.
Refining the value of secretory phospholipase A2 as a predictor of acute chest syndrome in sickle cell disease: results of a feasibility study (PROACTIVE) (2020)

Acute chest syndrome (ACS) is defined as fever, respiratory symptoms and a new pulmonary infiltrate in an individual with sickle cell disease (SCD). Nearly half of ACS episodes occur in SCD patients already hospitalized, potentially permitting pre-emptive therapy in high-risk patients. Simple transfusion of red blood cells may abort ACS if given to patients hospitalized for pain who develop fever and elevated levels of secretory phospholipase A2 (sPLA2). In a feasibility study (PROACTIVE; ClinicalTrials.gov NCT00951808), patients hospitalized for pain who developed fever and elevated sPLA2 were eligible for randomization to transfusion or observation; all others were enrolled in an observational arm. Of 237 enrolled, only 10 were randomized; one of the four to receive transfusion had delayed treatment. Of 233 subjects receiving standard care, 22 developed ACS. A threshold level of sPLA2 ≥ 48 ng/ml gave optimal sensitivity (73%), specificity (71%) and accuracy (71%), but a positive predictive value of only 24%. The predictive value of sPLA2 was improved in adults and patients with chest or back pain, lower haemoglobin concentration and higher white blood cell counts; and those receiving less than two-thirds maintenance fluids. The hurdles identified in PROACTIVE should facilitate design of a larger, definitive, phase 3 randomized controlled trial.
Ogilvie's syndrome after lower extremity arthroplasty. (1999)

Our case series identified increasing age, immobility and patient-controlled narcotic analgesia as potential risk factors for Ogilvie's syndrome in the postoperative orthopedic patient. Prompt recognition and early consultation with frequent clinical and radiographic monitoring are necessary to avoid colonic perforation and its significant associated death rate.
Sequential Olefin Metathesis — Intramolecular Asymmetric Heck Reactions in the Synthesis of Polycycles. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Some properties of catalog of (3, g) Hamiltonian bipartite graphs: orders, non-existence and infiniteness (2015)

The focus of this paper is on discussion of a catalog of a class of (3, g) graphs for even girth g. A (k, g) graph is a graph with regular degree k and girth g. This catalog is compared with other known lists of (3, g) graphs such as the enumerations of trivalent symmetric graphs and enumerations of trivalent vertex-transitive graphs, to conclude that this catalog has graphs for more orders than these lists. This catalag also specifies a list of orders, rotational symmetry and girth for which the class of (3, g) graphs do not exist. It is also shown that this catalog of graphs extends infinitely.
Batrachochytrium dendrobatidis in amphibians from the Po River Delta, Northern Italy (2019)

Batrachochytrium dendrobatidis is a pathogen infecting amphibians at the global scale and causing their decline, but knowledge of the distribution of this pathogen is far from complete. We sampled amphibians from three species (Hyla intermedia, Rana dalmatina and Pelophylax synklepton esculentus) to evaluate whether B. dendrobatidis infects amphibians in the Po River Delta Natural Park, Northern Italy. We detected the pathogen in one population of P. sk. esculentus (prevalence: 0.33). These findings expand the known distribution of B. dendrobatidis in Italy and add further concern to the conservation of amphibians in this area.
The role of mechatronics in crop product traceability (2000)

1. Agricultural machinery is becoming more and more intelligent. Position detection with GPS (Galileo after 2008), standardised electronic communication based on LBS / ISOBUS and a high number of different sensors will become basic components. 2. Precision Farming seems to be the farming strategy and practise of the future. 3. Product traceability needs information gathering, processing, integration into the farm management and supply to/from the trade. 4. Within mobile agricultural equipment GPS and the standardised communication by ISO 11783 opens the best possibilities for traceability. 5. Sensors available today sense a wide variety of process parameters. There is a big demand for the detection of product quality, ingredients and parameters defined by the consumers. 6. Traceability exceeds existing security concepts. Manual input allows manipulation. Automation may be the adequate answer.
Ring opening reactions of [M(CO)3(η1-Ph2PCH2PPh2)(η2-Ph2PCH2PPh2)] M = Cr, Mo, or W with Rh or Ir complexes to give bimetallic systems: synthesis of [(OC)3Mo(µ-Ph2PNHPPh2)2RhCl(CO)] (1984)

Complexes of the type [(OC)3M(µ-Ph2PCH2PPh2)2M′X(CO)] or [(OC)3M(µ-Ph2PCH2PPh2)2M′(CO)2]+PF6– have been made either as described in the title or by a ring opening reaction of [M′(CO)(η2-Ph2PCH2PPh2)2]Cl (M′= Rh or Ir) with a labile Cr, Mo, or W carbonyl derivative: the first bimetallic complex of Ph2PNHPPh2 is described.
Atherogenic concentrations of low-density lipoprotein enhance endothelial cell generation of epoxyeicosatrienoic acid products. (1990)

To investigate the effects of protracted low-density lipoprotein (LDL) exposure on endothelial cell (EC) epoxyeicosatrienoic acid (EET) generation, human umbilical vein ECs were incubated in atherogenic concentrations of LDL (240 mg cholesterol per deciliter) (LDL-EC). After 4 days' incubation with LDL, EC were stimulated with human thrombin in the presence of 1-[14C]-arachidonic acid. Substantially more EET products were generated by LDL-ECs than by cells not exposed to high levels of LDL (C-EC). Thrombin stimulation caused LDL-EC to produce five- to eightfold more in 14,15-EET, 11,12-EET, 8,9-EET, and 5,6-EET, with 14,15-EET as the major product. This is the first demonstration, to date, that EETs can be induced in EC. Metapyrone (SKF-525A) markedly inhibited EC EET generation, indicating a role for the cytochrome P-450 enzyme system in human EC arachidonic acid metabolism. One EET product, 14,15-EET, has been found to be chemotactic and to promote adhesion of U937 cells, a human monocytic lymphoma cell line, to EC. Thus, protracted exposure to atherogenic LDL concentrations increases the generation of chemotactic and adhesion factors (ie, 14,15-EET) after thrombin stimulation, possibly through the cytochrome P-450 enzyme system.
Does Early Postresuscitation Stress Hyperglycemia Affect 72-Hour Neurologic Outcome? Preliminary Observations in the Swine Model (2011)

In this standard porcine model of witnessed out-of-hospital cardiac arrest, early postresuscitation stress hyperglycemia did not appear to affect neurologic outcome. During the prehospital phase of treatment and transport, treatment of hyperglycemia by emergency medical services providers may not be warranted.
Orthovoltage radiation therapy treatment planning using Monte Carlo simulation: treatment of neuroendocrine carcinoma of the maxillary sinus (1997)

Dose distributions that result from treating a patient with orthovoltage beams are best determined with a treatment planning system that uses the Monte Carlo method, and such systems are not readily available. In the present work, the Monte Carlo method was used to develop a computer code for determining absorbed dose distributions in orthovoltage radiation therapy. The code was used in planning treatment of a patient with a neuroendocrine carcinoma of the maxillary sinus. Two lateral high-energy photon beams supplemented by an anterior orthovoltage photon beam were utilized in the treatment plan. For the clinical case and radiation beams considered, a reasonably uniform dose distribution (+/- 10%) is achieved within the target volume, while the dose to the lens of each eye is 4-8% of the prescribed dose. Therefore, an orthovoltage photon beam, when properly filtered and optimally combined with megavoltage beams, can be effective in the treatment of cancers below the skin, providing that accurate treatment planning is carried out to establish with accuracy and precision the doses to critical structures.