gebhart/patrepeval huggingface dataset:
Optimizing thread throughput for multithreaded workloads on memory constrained CMPs (2008)

Multi-core designs have become the industry imperative, replacing our reliance on increasingly complicated micro-architectural designs and VLSI improvements to deliver increased performance at lower power budgets. Performance of these multi-core chips will be limited by the DRAM memory system: we demonstrate this by modeling a cycle-accurate DDR2 memory controller with SPLASH-2 workloads. Surprisingly, benchmarks that appear to scale well with the number of processors fail to do so when memory is accurately modeled. We frequently find that the most efficient configuration is not the one with the most threads. By choosing the most efficient number of threads for each benchmark, average energy delay efficiency improves by a factor of 3.39, and performance improves by 19.7%, on average. We also introduce a shadow row of sense amplifiers, an alternative to cached DRAM, to explore potential power/performance impacts. The shadow row works in conjunction with the L2 Cache to leverage temporal and spatial locality across memory accesses, thus attaining average and peak speedups of 13% and 43%, respectively, when compared to a state-of-the-art DRAM memory scheduler.
View-based vs. place-based navigation: What is recognized in recognition-triggered responses? (1998)

. The usage of landmark information in a route navigation task is investigated in a virtual environment. After learning a route, subjects were released at intermediate points along the route and asked to indicate the next movement direction required to continue the route. At each decision point, three landmarks were present, one of which was viewed centrally and two which appeared in the periphery of the visual field when approaching the decision point. Replacement of the landmarks in the test phase did not affect subjects&amp;apos; performance as long as the direction informations associated with each landmark and landmark position (left, central, right) during the learning phase were consistent. Only if landmarks were combined that carried conflicting movement informations, a reduced performance is observed. We conclude that local views and objects are recognized individually and that the associated directions are combined in a voting scheme. No evidence was found for a recognition of places ...
Resident mesenchymal vascular progenitors modulate adaptive angiogenesis and pulmonary remodeling via regulation of canonical Wnt signaling (2020)

Adaptive angiogenesis is necessary for tissue repair, however, it may also be associated with the exacerbation of injury and development of chronic disease. In these studies, we demonstrate that lung mesenchymal vascular progenitor cells (MVPC) modulate adaptive angiogenesis via lineage trace, depletion of MVPC, and modulation of β-catenin expression. Single cell sequencing confirmed MVPC as multipotential vascular progenitors, thus, genetic depletion resulted in alveolar simplification with reduced adaptive angiogenesis. Following vascular endothelial injury, Wnt activation in MVPC was sufficient to elicit an emphysema-like phenotype characterized by increased MLI, fibrosis, and MVPC driven adaptive angiogenesis. Lastly, activation of Wnt/β-catenin signaling skewed the profile of human and murine MVPC toward an adaptive phenotype. These data suggest that lung MVPC drive angiogenesis in response to injury and regulate the microvascular niche as well as subsequent distal lung tissue architecture via Wnt signaling.
Growth ofEscherichia coli at elevated temperatures (2005)

In our studies to develop a simple and reliable method for the generation of recombinant adenoviruses (Fotadar et al . 2003), we noted that the E. coli (BJ5183 and DH5alpha) survived a heat-shock of 45 degrees C for 5 minutes in 0.1 M calcium chloride. As a result, we investigated the growth of E. coli (DH5alpha) at elevated temperatures. We hereby demonstrate that contrary to previous observations (Cooper et al . 2001 and Bronikowski et al . 2001) E. coli can grow consistently at a temperature as high as 49 degrees C, in spite of the fact that growth beyond 40 degrees C can generally be prohibitive. Hence, it is quite likely that these E. coli (DH5alpha) may have acquired mutations which permit them to grow reproducibly at 49 degrees C. Growth of E. coli above 49 degrees C (up to 53 degrees C) was also observed, but this was sporadic and not reproducible. This result could extend the utility of these organisms for cloning and manipulations requiring high temperature.
A method to compute the local birefringence vector in twisted and bent antiresonant hollow-core fibers (2023)

This work proposes a technique to elucidate mode coupling when antiresonant fibers are twisted and bent. From this, we show how the birefringence of a nested antiresonant nodeless fiber changes as function of the deployment.
Electrically-driven carbon nanotube-based plasmonic laser on silicon (2015)

Photonic signal processing requires efficient on-chip light sources with higher modulation bandwidths. Today’s conventional fastest semiconductor diode lasers exhibit modulation speeds only on the order of a few tens of GHz due to gain compression effects and parasitic electrical capacitances. Here we theoretically show an electrically-driven carbon nanotube (CNT)-based laser utilizing strong light-matter-interaction via monolithic integration into Silicon photonic crystal nanobeam (PCNB) cavities. The laser is formed by single-walled CNTs inside a combo-cavity consisting of both a plasmonic metal-oxide-semiconductor hybrid mode embedded in the one dimensional PCNB cavity. The emission originates from interband recombinations of electrostatically-doped nanotubes depending on the tubes’ chirality towards matching the C-band. Our simulation results show that the laser operates at telecom frequencies resulting in a power output > 3 (100) µW and > 100 (1000)’s GHz modulation speed at 1 × (10 × ) threshold. Such monolithic integration schemes provide an alternative promising approach for light source in future photonic integrated circuits.
Contribution a l'analyse de la stabilite des circuits non-lineaires. Application a la c. A. De dispositifs microondes (1989)

Ce travail propose une etude de la stabilite des circuits non-lineaires microondes, basee sur la methode de l'equilibrage harmonique ou spectral. Ce type d'analyse est un complement indispensable de la methode d'equilibrage qui permet de valider des solutions dont la nature est choisie a priori et constitue donc un module indispensable pour obtenir des solutions sures. La methode d'analyse est basee sur la theorie de nyquist et sur la theorie des bifurcations. Elle a ete appliquee avec succes a l'etude de diviseurs de frequence ainsi qu'a la determination de la stabilite du point de polarisation d'un dispositif a tec. Elle permet une analyse approfondie des comportements dynamiques des circuits non-lineaires qui doit conduire a une conception plus reflechie des dispositifs microondes monolithiques
INHIBITION OF AUTONOMOUS HUMAN KERATINOCYTE PROLIFERATION AND (1992)

SUMMARY We previously demonstrated that human keratinocyte cultures proliferate in the absence of polypeptide growth factors (autonomous growth) and that this autonomous growth is blocked by interaction of heparin with a human keratinocyte-derived autocrine factor (KAF) which we identified as amphiregulin (AR). In the present study, we demonstrate that sulfated polysaccharides other than heparin (low and high molecular weight dextran sulfates) also inhibit the AR-mediated autonomous proliferation of human keratinocytes. Furthermore, sulfated polysaccharides such as high and low molecular weight dextran sulfates, heparan sulfate and, to a lesser extent, chondroitin sulfates B and C were also shown to be inhihitors of human keratinocyte-derived AR (k-d AR)-stimulated DNA synthesis in quiescent murine AKR-2B cell cultures. Our results demonstrate that sulfation of polysaccharides is required for AR inhibitory activity, and that several sulfated polysaccharides (other than heparin) can act as inhibitors of AR-mediated autonomous proliferation in human epidermal keratinocytes and as inhibitors of k-d AR-mediated mitogenic activity in AKR-2B cells.
Neoadjuvant hormonal therapy and radical prostatectomy for clinical stage C carcinoma of the prostate (1994)

Neoadjuvant hormonal therapy prior to radical prostatectomy offers little probability of rendering patients with clinical stage C carcinoma of the prostate free of disease. Further investigation of the efficacy of this treatment should be accomplished in randomized trials.
FGF8 is essential for formation of the ductal system in the male reproductive tract (2011)

During development of the urogenital tract, fibroblast growth factor 8 (Fgf8) is expressed in mesonephric tubules, but its role in this tissue remains undefined. An evaluation of previously generated T-Cre-mediated Fgf8-deficient mice (T-Cre; Fgf8(flox/Δ2,3) mice), which lack Fgf8 expression in the mesoderm, revealed that the cranial region of the Wolffian duct degenerated prematurely and the cranial mesonephric tubules were missing. As a result, the epididymis, vas deferens and efferent ductules were largely absent in mutant mice. Rarb2-Cre was used to eliminate FGF8 from the mesonephric tubules but to allow expression in the adjacent somites. These mutants retained the cranial end of the Wolffian duct and formed the epididymis and vas deferens, but failed to elaborate the efferent ductules, indicating that Fgf8 expression by the mesonephric tubules is required specifically for the formation of the ductules. Ret knockout mice do not form the ureteric bud, a caudal outgrowth of the Wolffian duct and progenitor for the collecting duct network in the kidney, but they do develop the cranial end normally. This indicates that Fgf8, but not Ret, expression is essential to the outgrowth of the cranial mesonephric tubules from the Wolffian duct and to the development of major portions of the sex accessory tissues in the male reproductive tract. Mechanistically, FGF8 functions upstream of Lhx1 expression in forming the nephron, and analysis of Fgf8 mutants similarly shows deficient Lhx1 expression in the mesonephric tubules. These results demonstrate a multifocal requirement for FGF8 in establishing the male reproductive tract ducts and implicate Lhx1 signaling in tubule elongation.
Prototype of 5G Integrated with TSN for Edge-Controlled Mobile Robotics (2022)

The digitization of industries enables a rapid transformation from mass production to individualized manufacturing. Communication plays an essential role in this digital transformation; in particular, wireless communication enables a high degree of flexibility, dynamic interactions, and mobility support in production systems. This paper presents an implementation of a 5G system with Time-Sensitive Networking (TSN) and analyzes a typical industrial use case involving cloud-controlled mobile robots. A prototype setup integrating 5G in a TSN network has been completed to evaluate the 5G-TSN performance for industrial applications. The integrated 5G and TSN prototype has been evaluated with over the air tests in an industrial shopfloor using TSN features of traffic shaping and scheduling.
EPR spectra of MoS2/C60 (2010)

Abstract The X‐band electron paramagnetic resonance (EPR) spectra of MoS 2 /C 60 have been studied. A strong T ‐dependent g ‐shift and photoconductivity have been observed. The electronic state of molybdenum was found to be Mo 3+ .
Cementation of Copper on Aluminum in Alkaline Solutions (1996)

Cementation of copper onto aluminum is a galvanic process resulting from the dissolution of aluminum metal in alkaline media. The kinetics of cementation of copper onto aluminum in alkaline solutions has been investigated using powder and flat substrates. The results show that this process follows a first‐order reaction rate. The rate of the reaction is found to increase with an increase in NaOH concentration. No significant differences are found between flat and powder substrates, however, the results suggest a strong influence of surface area on the reaction rate. X‐ray diffraction and x‐ray fluorescence methods show that the cemented product is pure copper. Scanning electron microscopy photographs show that the cemented Cu has a bulbous (botryoidal) type of structure.
Characterization of pseudo‐continuous arterial spin labeling: Simulations and experimental validation (2017)

By use of appropriate parameter settings, labeling efficiencies of around 90% are feasible, independent of expected off-resonance gradients at 3T. Magn Reson Med 79:1638-1649, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Local discriminant bases in machine fault diagnosis using vibration signals (2005)

Wavelets and local discriminant bases (LDB) selection algorithm is applied to vibration signals in a single-cylinder spark ignition engine for feature extraction and fault classification. LDB selects a complete orthogonal basis from a wavelet packet
Analysis of actin and tropomyosin in hearts of cardiac mutant axolotls by two‐dimensional gel electrophoresis, western blots, and immunofluorescent microscopy (1989)

When homozygous, recessive mutant gene c in Ambystoma mexicanum results in a failure of embryonic heart function. This failure is apparently due to abnormal inductive influences from the anterior endoderm resulting in an absence of normal sarcomeric myofibril formation. Biochemical and immunofluorescent studies were undertaken to evaluate the contractile proteins actin and tropomyosin in normal and mutant hearts. For the immunofluorescent studies, cardiac tissues were fixed in periodate-lysine-paraformaldehyde, frozen sectioned, and immunostained by an indirect method with monospecific polyclonal antibodies produced against highly purified chicken heart actin and tropomyosin. In normal hearts, both antiactin and antitropomyosin stained the myofibrillar I-bands intensely. In mutant hearts, intensity of staining with antiactin antibody was similar to normal, although sarcomeric patterns were not observed. Staining intensity for tropomyosin with antitropomyosin antibody was significantly reduced in mutant hearts when compared to normal. Biochemical studies were used to evaluate antibody specificity, antigenic variability, and relative protein concentrations of actin and tropomyosin in normal and mutant cardiac tissues. Tissue homogenates were electrophoresed in two dimensions, and second-dimension slab gels were either Coomassie Blue silver-stained or transblotted onto nitrocellulose and the proteins stained with antibodies. Stained gels and immunoblots of cardiac proteins reveal that the amounts of actin isoforms are identical in normal and mutant hearts. However, these methods demonstrate a significantly reduced amount of tropomyosin in mutant tissue. This confirms earlier studies suggesting reduced amounts of tropomyosin in mutant hearts based upon immunological assays. Thus, failure of normal myofibrillogenesis in gene c mutant hearts does not appear to result from a change in actin isoform composition but may be related to a deficiency in tropomyosin.
Lead-free Tin Alloys as Substitutes for Tin-lead Alloy Plating (1997)

SummaryThe use of lead and lead-components is prohibited or restricted for many applications. Presently there is therefore a discussion on the possibility to substitute lead as an alloying element in solder-alloys for electronic applications. The advantages for lead-containing tin-alloys as solder and solderable coating are for example low melting-point, effective prevention of whisker growth, low price and high availability. From the view of electrochemical deposition, the system is favoured because of the similarity of the standard potentials of both elements. It is therefore possible to deposit from acidic electrolytes without complexing agents any tin-lead ratio. Stable and mature processes are available for technical applications.In the search for lead-free solders these arguments must be considered. The electrolytic deposition of any alternative for tin-lead should be possible from systems which are non-hazardous to people or the environment.Taking account of the above mentioned arguments the paper describes initial experiments on the deposition of tin-bismuth-alloys. The eutectic Sn/Bi-alloy is already used as solder for special applications. By adjusting the Sn/Bi-ratio in the electrolyte, it is possible to deposit coatings, which have a similar range of melting point as known Sn/Pb-alloys. Preliminary results on solderability hardness and topography of different Sn/Bi-alloys are presented.
Dental plaque bacteria with reduced susceptibility to chlorhexidine are multidrug resistant (2016)

The study highlights the requirement for increased vigilance of the presence of multidrug resistant bacteria in dental plaque and raises a potential risk of long-term use of oral care products containing antimicrobial agents for the control of dental plaque.
A STUDY OF DYSPROTEINEMIA AND FIBRINOLYSIS IN PATIENTS WITH UROLOGIC CANCERS (1974)

Plasma proteins, serum CRP, red cell sedimentation rate, fibrinolytic activity and antiplasmin in blood have been studied in 55 patients with urologic malignancies (transitional cell carcinoma of the bladder; 30 cases, secondary carcinoma of the bladder; 11 cases, renal cell carcinoma; 10 cases, transitional cell carcinoma of the renal pelvis and ureter; 4 cases) with special reference to the extent and metastasis of the tumor.A higher frequency of dysproteinemia and of abnormal level in the other examinations was observed in patients with metastases or wide-spread infiltrating carcinoma, while the indefinite tendency for significant change in their levels was noted in patients with bladder carcinoma of Stages A and B showing relatively localized growth within the bladder wall.Among the laboratory findings an abnormal increase of plasma fibrinogen level was most closely related to progressive conditions of the carcinomas, including the remote metastases and advanced regional growth. No significant difference was observed between the pre-and post-operative levels of each examination in any group of the carcinomas. However, the levels of serum albumin, α1-, α2- and γ-globulins, red cell sedimentation rate, plasma fibrinogen and euglobulin lysis time showed a significant difference between the groups of metastatic and non-metastatic carcinoma, respectively. It was thought that the follow-up study using these 7 laboratory tests may be of predective value for the progressive development of the tumor.
Detecting changes in large data sets of payment card data (2007)

An important problem in data mining is detecting changes in large datasets. Although there are a variety of change detection algorithms that have been developed, in practice it can be a problem to scale these algorithms to large data sets due to the heterogeneity of the data. In this paper, we describe a case study involving payment card data in which we built and monitored a separate change detection model for each cell in a multi-dimensional data cube. We describe a system that has been in operation for the past two years that builds and monitors over 15,000 separate baseline models and the process that isused for generating and investigating alerts using these baselines.
1H–1H Double Quantum NMR Investigation of Proton Dynamics in Solid Acids (2016)

Currently, the most popular proton exchange membrane (PEM) for fuel cell applications is Nafion. However, Nafion does not retain its high conductivity at high temperatures due to its dependence on water for proton transport. Because operational temperatures higher than the evaporation point of water are desirable, a family of solid acids was investigated. Cations known to transport protons were paired with anions to make acidic salts. Solid acids discussed here include imidazole paired with trifluoromethanesulfuric acid as well as imidazole, benzimidazole and adenine paired with methanesulfonic acid. Solid-state NMR was utilized to show the relative mobility of protons through double-quantum filter (DQF) experiments. The POST-C7 homonuclear dipolar-recoupling scheme was paired with DUMBO homonuclear decoupling to produce 1H double-quantum coherence buildup curves for the hydrogen-bonded protons of interest. Experimental buildup curves, which reflect both local structure as well as dynamics, are compared to theoretical curves of the static system. The SPINEVOLUTION-simulated curves utilized up to eight pairs of homonuclear dipolar couplings within a sphere of 7 Å diameter centered on the proton of interest. Steep buildup of the DQ curve and maxima at short recoupling times in the buildup curves indicate strong dipole–dipole coupling and are interpreted to indicate limited dynamics of the H-bonded protons. In contrast, shallower buildup curves and maxima at longer recoupling times imply that H-bonded protons (in an otherwise similar structure) are associated with local mobility, which reduces their local dipolar coupling and may facilitate proton transport. Bulk proton conductivities measured via electrochemical impedance spectroscopy were compared to DQF measurements to understand proton conduction within these materials.
Interaction of Saffron Carotenoids as Anticancer Compounds with ctDNA, Oligo (dG.dC) 15 , and Oligo (dA.dT) 15 (2007)

Crocin and crocetin are two important natural saffron carotenoids, which, along with dimethylcrocetin (DMC) as a semi-synthetic product, are responsible for its color. Many biological properties of saffron have been reported, among which the anticancer property is the most important. Some anticancer drugs have direct interaction with DNA, and thus the present study attempted to investigate the interaction of three major saffron carotenoids-crocin, crocetin, and DMC--with calf thymus DNA (ctDNA) and oligonucleotides. The spectrophotometric data showed some changes in ctDNA absorption spectra due to the formation of complex with saffron extract and each of these three components. Also, all the three components caused the quenching of the fluorescence emission of ctDNA-ethidium bromide complex. The Scatchard analysis of these data indicated a noncompetitive manner for quenching, which is accompanied by the outside groove-binding pattern. The circular dichroism (CD) spectra also indicated the nonintercalative binding and induction of the conformational changes, and B to C transition in ctDNA structure and then unstacking of ctDNA bases at higher concentrations of the carotenoids. The CD spectra of G.C and A.T oligonucleotides after addition of these carotenoids indicated the transition from B- to C-DNA, which is very similar to the ctDNA spectral changes. The DeltaG(H(2)O), the best parameter for the estimation of macromolecule stability, was determined for ctDNA denaturation using dodecyl trimethylammonium bromide in the absence and presence of crocin, crocetin, or DMC. Our results showed a decrease in the Delta G(H(2)O), indicating the ctDNA destabilization due to its interaction with the mentioned ligands. In conclusion, the results show that saffron and its carotenoids interact with DNA and induce some conformational changes in it. Of these carotenoids, the order of potential of interaction with DNA is crocetin > DMC >> crocin.
Supplementary Figure Legends 1-4, Movie Legends 1-8 from Analysis of Mitosis and Antimitotic Drug Responses in Tumors by <i>In Vivo</i> Microscopy and Single-Cell Pharmacodynamics (2023)

Supplementary Figure Legends 1-4, Movie Legends 1-8 from Analysis of Mitosis and Antimitotic Drug Responses in Tumors by &lt;i&gt;In Vivo&lt;/i&gt; Microscopy and Single-Cell Pharmacodynamics