gebhart/patrepeval huggingface dataset:
Aspects of Semantics and Pragmatics of Dialogue. SemDial 2010, 14th Workshop on the Semantics and Pragmatics of Dialogue (2010)

The papers collected in this book cover a range of topics in semantics and pragmatics of dialogue. All these papers were presented at SemDial 2010, the 14th Workshop on the Semantics and Pragmatics of Dialogue. This 14th edition in the SemDial series, also known as PozDial, took place in Poznań (Poland) in June 2010, and was organized by the Chair of Logic and Cognitive Science (Institute of Psychology, Adam Mickiewicz University).&#13;\n&#13;\nFrom over 30 submissions overall, 14 were accepted as full papers for plenary presentation at the workshop, and all are included in this book. In addition, 10 were accepted as posters, and are included here as 2-4 page short papers. Finally, we also include abstracts from our keynote speakers.&#13;\n&#13;\nWe hope that the ideas gathered in this book will be a valuable source of up-to-date achievements in the field, and will become a valuable inspiration for new ones.&#13;\n&#13;\nWe would like to express our thanks to all those who submitted to and participated in SemDial 2010, especially the invited speakers: Dale Barr (University of Glasgow), Jonathan Ginzburg (King's College London), Jeroen Groenendijk (University of Amsterdam) and Henry Prakken (Utrecht University, The University of Groningen).&#13;\n&#13;\nLast but not least, we would like to thank everybody engaged in the workshop organization -- the chairs, the local organizing committee for their hard work in Poznań, and the programme committee members for their thorough and helpful reviews.
Complete Genome Sequence of a Novel GV.2 Sapovirus Strain, NGY-1, Detected from a Suspected Foodborne Gastroenteritis Outbreak (2015)

Sapoviruses, members of the family Caliciviridae, are genetically highly diverse. We report here the first complete genome sequence of a genogroup V genotype 2 sapovirus strain, NGY-1, detected from fecal samples of a suspected foodborne gastroenteritis outbreak, determined using a metagenomic sequencing approach.
Sharing of motion vectors in 3D video coding (2005)

Current investigations in the area of 3D video systems are based on depth map sequences. They are used to determine the compatibility with conventional 2D video systems. Instead of transmitting or storing two 2D video sequences for each eye, 2D video and the appropriate depth information is delivered. If the viewer owns a standard TV set, only the video is displayed. In the case of additionally installed hardware, e.g. stereoscopic display or shutter glasses, a second virtual view are computed based on the depth information. The amount of data for transmitting or storing the additional depth information is limited to 20 percent of the MPEG-2 coded 2D video data stream. This paper shows an approach for compression of the depth map sequences based on MPEG-2 within the predetermined limit by sharing the vectors for motion compensation with the 2D video data.
Selection of a time-varying Volterra model using multiple hypothesis testing (2002)

We consider the system identification problem using a time-varying quadratic Volterra model. To enable identification a set of known basis sequences are used in the model to approximate the time-variation of the true system. To reduce the number of parameters in the model we wish to determine which individual sequences are significant in this approximation. Multiple hypothesis testing procedures are employed to select significant sequences. The tests include the Bonferroni test, Holm's (1979) sequentially rejective Bonferroni test, and Hommel's (1988) extension to Simes' (1986) procedure [5].
Web‐based data warehouse on gene expression in human colorectal cancer (2005)

Based on biomedical literature databases, we tried a first step for constructing a gene expression "data warehouse" specific to human colorectal cancer (CRC). Results of genome-wide transcriptomic research were available from 12 studies, using various technologies, namely, SAGE, cDNA and oligonucleotide arrays, and adaptor-tagged amplification. Three studies analyzed CRC cell lines and nine studies of human samples. The total number of patients was 144. Out of 982 up- or down-regulated genes, 863 (88%) were found to be differentially expressed in a single study, 88 in two studies, 22 in three studies, 7 in four studies, and only 2 genes in six studies. Eight large-scale proteomics studies were published in CRC, using 2-D-, SDS- or free-flow electrophoresis, involving only 11 patients. Out of 408 differentially expressed proteins, 339 (83%) were found to be differentially expressed only in a single study, 16 in three studies, 10 in four studies, 3 in five, and 1 in eight studies. Confirmation at proteome level of results obtained with large-scale transcriptomics studies was possible in 25%. This proportion was higher (67%) for reproducing proteome results using transcriptomics technologies. Obviously, reproducibility and overlapping between published gene expression results at proteome and transcriptome level are low in human CRC. Thus, the development of standardized processes for collecting samples, storing, retrieving, and querying gene expression data obtained with different technologies is of central importance in translational research.
Simulation, Fabrication and Characterization of THz Metamaterial Absorbers (2012)

Metamaterials (MM), artificial materials engineered to have properties that may not be found in nature, have been widely explored since the first theoretical(1) and experimental demonstration(2) of their unique properties. MMs can provide a highly controllable electromagnetic response, and to date have been demonstrated in every technologically relevant spectral range including the optical(3), near IR(4), mid IR(5) , THz(6) , mm-wave(7) , microwave(8) and radio(9) bands. Applications include perfect lenses(10), sensors(11), telecommunications(12), invisibility cloaks(13) and filters(14,15). We have recently developed single band(16), dual band(17) and broadband(18) THz metamaterial absorber devices capable of greater than 80% absorption at the resonance peak. The concept of a MM absorber is especially important at THz frequencies where it is difficult to find strong frequency selective THz absorbers(19). In our MM absorber the THz radiation is absorbed in a thickness of ~ λ/20, overcoming the thickness limitation of traditional quarter wavelength absorbers. MM absorbers naturally lend themselves to THz detection applications, such as thermal sensors, and if integrated with suitable THz sources (e.g. QCLs), could lead to compact, highly sensitive, low cost, real time THz imaging systems.
Robotic QM/MM-driven maturation of antibody combining sites (2016)

In vitro selection of antibodies from large repertoires of immunoglobulin (Ig) combining sites using combinatorial libraries is a powerful tool, with great potential for generating in vivo scavengers for toxins. However, addition of a maturation function is necessary to enable these selected antibodies to more closely mimic the full mammalian immune response. We approached this goal using quantum mechanics/molecular mechanics (QM/MM) calculations to achieve maturation in silico. We preselected A17, an Ig template, from a naïve library for its ability to disarm a toxic pesticide related to organophosphorus nerve agents. Virtual screening of 167,538 robotically generated mutants identified an optimum single point mutation, which experimentally boosted wild-type Ig scavenger performance by 170-fold. We validated the QM/MM predictions via kinetic analysis and crystal structures of mutant apo-A17 and covalently modified Ig, thereby identifying the displacement of one water molecule by an arginine as delivering this catalysis.
Ly9 (CD229) Cell-Surface Receptor is Crucial for the Development of Spontaneous Autoantibody Production to Nuclear Antigens (2013)

The Signaling Lymphocyte Activation Molecule Family (SLAMF) genes, which encode cell-surface receptors that modulate innate and adaptive immune responses, lay within a genomic region of human and mouse chromosome 1 that confers a predisposition for the development of systemic lupus erythematosus (SLE). Herein, we demonstrate that the SLAMF member Ly9 arises as a novel receptor contributing to the reinforcement of tolerance. Specifically, Ly9-deficient mice spontaneously developed features of systemic autoimmunity such as the production of anti-nuclear antibodies (ANA), -dsDNA, and -nucleosome autoantibodies, independently of genetic background [(B6.129) or (BALB/c.129)]. In aged (10- to 12-month-old) Ly9 (-/-) mice key cell subsets implicated in autoimmunity were expanded, e.g., T follicular helper (Tfh) as well as germinal center (GC) B cells. More importantly, in vitro functional experiments showed that Ly9 acts as an inhibitory receptor of IFN-γ producing CD4(+) T cells. Taken together, our findings reveal that the Ly9 receptor triggers cell intrinsic safeguarding mechanisms to prevent a breach of tolerance, emerging as a new non-redundant inhibitory cell-surface receptor capable of disabling autoantibody responses.
Data-Driven Fault Diagnostics and Prognostics for Predictive Maintenance: A Brief Overview (2019)

Predictive Maintenance (PdM) is a maintenance strategy which predicts equipment failures before they occur and then performs maintenance in advance to avoid the occurrence of failures. A PdM system generally consists of four main components: data acquisition and preprocessing, fault diagnostics, fault prognostics and maintenance decision-making. Recently, massive condition monitoring data of equipment, also known as the industrial big data, has shown explosive growth. A large number of research works, including theoretical studies and industrial applications, have focused on implementing PdM with industrial big data analytics. This paper aims to provide a brief overview on the PdM system in the era of big data, with a particular emphasis on models, methods and algorithms of data-driven fault diagnostics and prognostics. In addition, a conclusion with a discussion on possible future trends in the research field of PdM is also given.
Sunitinib blocks tumoral growth on an orthotopic model of human testicular germ cell tumors (2008)

16070 Background: Germ cell tumors (GCTs) of the testis are highly curable, but patients refractory to cisplatin (CDDP) based chemotherapy have a poor prognosis. Several studies support an important role of angiogenesis in GCT, suggesting anti-angiogenic treatment as a good alternative. Sunitinib is an oral multitarget tyrosine kinase receptor with antiangiogenic and antitumoral activities. We evaluate the effect of sunitinib, CDDP or the combination of both compounds on tumoral growth using an orthotopic model of human testicular GCTs (Piulats et al., AACR 2006; abstract 2760). Methods: Mice were implanted with 4 different tumors: a yolk sac without prior exposure to CDDP; a choriocarcinoma from a CDDP-resistant patient; and finally both a choriocarcinoma without prior exposure to CDDP and its CDDP refractory variant induced in mice by a continous CDDP exposure. Mice were treated with sunitinib (40 mg/kg, daily for 15 days), CDDP (2 mg/kg three times at 5-day interval) or combination of both. Animals were sacrificed once tumors in vehicle-treated mice affected the well being of the animals and tumors were analyzed. Results: We observed a significant block of tumoral volume, decreased circulating αFP and βHCG serum levels, and longer survival after sunitinib treatment for all GCTs analyzed. Tumor disappeared when mice were treated combining CDDP and sunitinib. Moreover, in the model of CDDP refractory induced choriocarcinoma, sunitinib clearly blocked tumoral growth. Sunitinib treatment inhibited VEGFR1,2 and 3, Flt-3 and PDGFRα, levels in absence of any effect on EGFR or PDGFRβ levels. Conclusions: Sunitinib may play a role in the treatment of CDDP-resistant patients that warrants further investigation. No significant financial relationships to disclose.
Semantic deficits in ALS related to right lingual/fusiform gyrus network involvement (2019)

Dysfunction of the "hub" in the right lingual/fusiform gyrus can affect semantic deficit in ALS. Considering neuropsychological symptoms as network impairments is vital for understanding various diseases. FUND: MHLW and MEXT, Japan.
Exopolymer Diversity and the Role of Levan in Bacillus subtilis Biofilms (2013)

Exopolymeric substances (EPS) are important for biofilm formation and their chemical composition may influence biofilm properties. To explore these relationships the chemical composition of EPS from Bacillus subtilis NCIB 3610 biofilms grown in sucrose-rich (SYM) and sucrose-poor (MSgg and Czapek) media was studied. We observed marked differences in composition of EPS polymers isolated from all three biofilms or from spent media below the biofilms. The polysaccharide levan dominated the EPS of SYM grown biofilms, while EPS from biofilms grown in sucrose-poor media contained significant amounts of proteins and DNA in addition to polysaccharides. The EPS polymers differed also in size with very large polymers (Mw>2000 kDa) found only in biofilms, while small polymers (Mw<200 kD) dominated in the EPS isolated from spent media. Biofilms of the eps knockout were significantly thinner than those of the tasA knockout in all media. The biofilm defective phenotypes of tasA and eps mutants were, however, partially compensated in the sucrose-rich SYM medium. Sucrose supplementation of Czapek and MSgg media increased the thickness and stability of biofilms compared to non-supplemented controls. Since sucrose is essential for synthesis of levan and the presence of levan was confirmed in all biofilms grown in media containing sucrose, this study for the first time shows that levan, although not essential for biofilm formation, can be a structural and possibly stabilizing component of B. subtilis floating biofilms. In addition, we propose that this polysaccharide, when incorporated into the biofilm EPS, may also serve as a nutritional reserve.
Real frequency tearing layers with parallel dynamics and the effect on\n locking and resistive wall modes (2017)

Tearing modes with real frequencies in the plasma frame (i.e. in addition to\nthe Doppler shift due to $E\\times B$ rotation) are of potential importance\nbecause of their effect on the locking process. In particular, it has recently\nbeen shown [J. M. Finn, A. J. Cole, and D. P. Brennan, Phys. Plasmas (Letters),\n22:120701, 2015] that the Maxwell torque on the plasma in the presence of an\napplied error field is modified significantly for tearing modes having real\nfrequencies near marginal stability. In addition, it is known [J. M. Finn and\nR. A. Gerwin, Phys. Plasmas, 3:2344, 1996] that resistive wall tearing modes\ncan be destabilized below their no-wall limits by rotation, if the tearing\nmodes have real frequencies near marginal stability. In this paper we first\nderive the tearing mode dispersion relation with pressure gradient, field line\ncurvature and parallel dynamics in the resistive-inertial (RI) regime,\nneglecting the divergence of the $E\\times B$ drift and perpendicular\nresistivity. The results show that the usual Glasser effect, a toroidal effect\nwhich involves real frequencies, occurs in this simplified model, which ignores\nperpendicular resistivity and the divergence of the $E\\times B$ drift. We also\nfind, using a similar simple model, the surprising result that in the\nviscoresistive regime with pressure gradient, favorable curvature due to\ntoroidal effects, and parallel dynamics, a similar Glasser-like effect is\nfound. We show that in both regimes the existence of tearing modes with complex\nfrequencies is related to nearby electrostatic resistive interchange modes with\ncomplex frequencies. We discuss the effect on locking to an error field and the\nsignificant lowering of the threshold for destabilization of resistive wall\ntearing modes, which can be much more pronounced than the weak effect observed\nfor RI tearing modes without pressure-curvature drive in Finn and Gerwin, 1996.\n
Tension-Dependent Free Energies of Nucleosome Unwrapping (2016)

Nucleosomes form the basic unit of compaction within eukaryotic genomes, and their locations represent an important, yet poorly understood, mechanism of genetic regulation. Quantifying the strength of interactions within the nucleosome is a central problem in biophysics and is critical to understanding how nucleosome positions influence gene expression. By comparing to single-molecule experiments, we demonstrate that a coarse-grained molecular model of the nucleosome can reproduce key aspects of nucleosome unwrapping. Using detailed simulations of DNA and histone proteins, we calculate the tension-dependent free energy surface corresponding to the unwrapping process. The model reproduces <i>quantitatively</i> the forces required to unwrap the nucleosome and reveals the role played by electrostatic interactions during this process. We then demonstrate that histone modifications and DNA sequence can have significant effects on the energies of nucleosome formation. Most notably, we show that histone tails contribute asymmetrically to the stability of the outer and inner turn of nucleosomal DNA and that depending on which histone tails are modified, the tension-dependent response is modulated differently.
Extraction of personal features from stroke shape, writing pressure and pen inclination in ordinary characters (1999)

We propose an extraction method of personal features based on online handwritten characters including writing pressure and pen inclination information. In the proposed method, any handwritten character (i.e., ordinary character) is described by a set of three dimensional curves, and personal features are described by a set of Fourier descriptors for the three dimensional curves. From some simulation results using handwritten data, it is clear that the proposed method effectively extracts personal features from ordinary characters.
Reversible Tuning of Silver Quantum Dot Monolayers Through the Metal-Insulator Transition (1997)

The linear and nonlinear (χ (2) ) optical responses of Langmuir monolayers of organically functionalized silver quantum dots were measured as a continuous function of interparticle separation under near-ambient conditions. As the distance between metal surfaces was decreased from 12 to ∼5 angstroms, both quantum and classical effects were observed in the optical signals. When the separation was less than 5 angstroms, the optical second-harmonic generation (SHG) response exhibited a sharp discontinuity, and the linear reflectance and absorbance began to resemble those of a thin metallic film, indicating that an insulator-to-metal transition occurred. This transition was reversible.
Crystal structure of 1-(benzo[d]thiazol-2-yl)-3-phenylthiourea, C14H11N3S2 (2016)

Abstract C 14 H 11 N 3 S 2 , triclinic, P 1̅ (no. 2), a = 5.7607(5)Å, b = 9.8397(9) Å, c = 12.0920(11) Å, α = 72.899(4)°, β = 81.833(4)°, γ = 86.796(5)°, V = 648.40(10) Å 3 , Z = 2, R gt ( F ) = 0.0295, wR ref ( F 2 ) = 0.0797, T = 200(2) K.
Generation of a TLE3 heterozygous knockout human embryonic stem cell line using CRISPR-Cas9 (2016)

Here, we generated a monoallelic mutation in the TLE3 (Transducin Like Enhancer of Split 3) gene using CRISPR-Cas9 editing in the human embryonic stem cell (hESC) line WA01. The heterozygous knockout cell line, TLE3-447-D08-A01, displays partial loss of TLE3 protein expression while maintaining pluripotency, differentiation potential and genomic integrity.
ChemInform Abstract: Proton Affinity Distributions: A Scientific Basis for the Design and Construction of Supported Metal Catalysts (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Automated Classification of Beaked Whales and Other Small Odontocetes in the Tongue of the Ocean, Bahamas (2006)

Navy sonar has recently been associated with a number of marine mammal stranding events. Beaked whales have been the predominant species involved in a number of these strandings. Monitoring and mitigating the effects of anthropogenic noise on marine mammals are active areas of research. Key to both monitoring and mitigation is the ability to automatically detect and classify the animals, especially beaked whales. This paper presents a novel support vector machine based methodology for automated species level classification of small odontocetes. To date, the algorithm presented has been trained to differentiate the click vocalizations of Blainville's beaked whales (Mesoplodon densirostris) from the clicks produced by delphinids and from man-made sounds. The automated classification capability compliments the detection and tracking tools already developed through ONR funding for the monitoring and localization of whales at the Atlantic Undersea Test and Evaluation Center, Andros Island, Bahamas
AMB‐FUBINACA (FUB‐AMB) and related "spice" compounds induce gene‐dose effects in mice lacking cannabinoid‐1 receptor (CB1R) alleles (2019)

Synthetic cannabinoids (SCs), commonly known as ‘K2' or 'spice’, are a constantly evolving class of new psychoactive substances that pose public health risks. Little information is available about novel SCs when they first emerge into the recreational drug marketplace. In this study, we investigated the pharmacology of AMB‐FUBINACA (FUB‐AMB) and 5F‐AMB, two recently encountered indazole‐based SCs responsible for mass intoxications and fatalities. The effects of known cannabinoid‐1 receptor (CB1R) agonists AM‐2201 and Δ 9 ‐THC were examined for comparison. Groups of genetically‐engineered mice lacking CB1R alleles (CB1R −/− and CB1R +/−), and their C57Bl/6J wild‐type (WT) counterparts, received surgically‐implanted subcutaneous (s.c.) temperature transponders under isoflurane anesthesia. Beginning one week after surgery, mice received s.c. injection of either SCs or vehicle and were subjected to a “triad” test battery consisting of sequential assessment of: 1] body temperature, 2] catalepsy bar latency and 3] hot‐plate analgesia latency. All SCs induced significant dose‐ and time‐dependent hypothermia, catalepsy and analgesia in WT mice, which lasted up to 120 min. The rank order of potency was FUB‐AMB&gt;5F‐AMB=AM‐2201&gt;Δ 9 ‐THC. Importantly, ED 50 values in the triad test battery for FUB‐AMB (0.09–0.22 mg/kg, s.c.) were at least 50‐fold more potent than those associated with Δ 9 ‐THC (12.72–30.37 mg/kg, s.c.), and SCs were more efficacious in their ability to produce hypothermia. Homozygous CB1R −/− mice were not affected by any dose of the compounds tested, whereas heterozygous CB1R +/− mice displayed responses intermediate between homozygous and WT. CB1R binding assays in WT mouse brain revealed that IC 50 values for inhibition of [ 3 H]SR141716 binding were 1.2, 2.2, 12.6 and 50.6 nM for FUB‐AMB, AM‐2201, 5F‐AMB and Δ 9 ‐THC, respectively. Our findings demonstrate that newer indazole‐based SCs exert their effects via potent agonist actions at CB1R, and do not support the notion that SCs induce in vivo effects by non‐CB receptor mechanisms. Given the widespread abuse of synthetic cannabinoids, CB1R antagonists should be made available for overdose rescue, and medical marijuana could be deployed as an agonist treatment for dependence on these substances. Support or Funding Information This research was generously supported by IRP, NIDA, NIH (DA00523) This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .