gebhart/patrepeval huggingface dataset:
Borane-Trimethylamine (2008)

(borane–trimethylamine1) [75-22-9] C3H12BN (MW 72.95) InChI = 1S/C3H9N.BH3/c1-4(2)3;/h1-3H3;1H3 InChIKey = WVMHLYQJPRXKLC-UHFFFAOYSA-N (borane–triethylamine) [1722-26-5] C6H18BN (MW 115.02) InChI = 1S/C6H15N.BH3/c1-4-7(5-2)6-3;/h4-6H2,1-3H3;1H3 InChIKey = KDKNBGWKECQREO-UHFFFAOYSA-N (representative of the borane complexes of trialkylamines, mild reductants soluble in most organic solvents, less sensitive to hydrolysis even under acidic conditions than borohydrides or borane–pyridine; used in conjunction with Lewis or Brønsted acids to reduce carbon–oxygen and –nitrogen double bonds as well as indoles and acetals; can be used as borane carriers for olefin hydroboration and to activate carboxylic acids as acylating agents) Physical Data: mp 94–94.5 °C, bp 171 °C. Solubility: very sol methanol, diethyl ether, THF, toluene, and dichloromethane; sol water; insol hexane.1 Form Supplied in: colorless solid. Purification: vacuum sublimation.2 Handling, Storage, and Precautions: hydrolytically stable in neutral or even mildly acidic aqueous solution;3 thermally stable to 120 °C.4 Decomposition of excess reagent with aqueous acid1 generates hydrogen gas. Toxicity (intraperitoneal) rat LD50: 175 mg kg−1.5
Inhibitory effects of Lactobacillus plantarum lipoteichoic acid (LTA) on Staphylococcus aureus LTA-induced tumor necrosis factor-alpha production. (2008)

Staphylococcus aureus is a common etiologic agent for Gram-positive sepsis, and its lipoteichoic acid (LTA) may be important in causing Gram-positive bacterial septic shock. Here, we demonstrate that highly purified LTA (pLTA) isolated from Lactobacillus plantarum inhibited aureus LTA (aLTA)-induced TNF-alpha production in THP- cells. Whereas pLTA scarcely induced TNF-alpha production, aLTA induced excessive TNF-alpha production. Interestingly, aLTA-induced TNF-alpha production was inhibited by pLTA pretreatment. Compared with pLTA, aLTA induced strong signal transduction through the MyD88, NF-kappaB, and MAP kinases. This signaling, however, was reduced by a pLTA pretreatment, and resulted in the inhibition of aLTA-induced TNF-alpha production. Whereas dealanylated LTAs, as well as native LTAs, contributed to TNF- induction or TNF-alpha reduction, deacylated LTAs did not, indicating that the acyl chain of LTA played an important role in the LTA-mediated immune regulation. These results suggest that pLTA may act as an antagonist for aLTA, and that an antagonistic pLTA may be a useful agent for suppressing the septic shock caused by Gram-positive bacteria.
Preattentive Auditory Processing in Professional Musicians Versus Non-Musicians: An fMRI Study (2007)

In an fMRI study of 7 professional musicians, compared to 7 non-musicians, the response to an acoustic temporal mismatch parad img was examined. In both groups, a significant mismatch response was observed in the ri ght planum temporale which increased monotonically with incr easing deviance from the standard temporal stimulus pa ttern. A significant group difference between musici ans and non-musicians was found in the left an terior hippocampus, where only the musicans, but not the non-musicians showed a significant mi smatch response. This can be interpreted as an indication o f neuroplasticity in response to extensive musical training.
Enzymes, Baking Processes (2010)

Introduction Fungal α-Amylases for Bread Making Maltogenic α-Amylase for Antistaling Xylanases and Pentosanases as Dough Conditioners Lipase for Dough Conditioning Oxidases for Bread Making: Replacing Chemical Oxidants Synergistic Effects of Enzymes Enzymes for Dough Conditioning Enzymes for Extending Shelf Life and Improving Crumb Softness and Elasticity Enzymes for Dough Strengthening References
Importance of Lean Body Mass in the Oncologic Patient (2012)

Loss of lean body develops from an imbalance in protein synthesis and catabolism and is associated with a variety of different disease and nondisease states, including severe malnutrition, cachexia, and physiologic age-related loss (sarcopenia). Loss of lean body mass is prevalent among a significant proportion of the elderly population and has been associated with increased adverse clinical outcomes. Recognition of individuals at risk for low lean body mass may be difficult due to unequal distribution of losses across muscle and adipose compartments, and individuals who are both obese and sarcopenic demonstrate the highest risk for adverse events. Cross-sectional imaging modalities provide an accessible and easily interpretable means of quantifying lean muscle content and are routine diagnostic tests for cancer patients. As a result, a growing body of literature has developed characterizing the importance of low lean body mass as a poor prognostic factor among cancer patients, regardless of age. Cancer patients, especially those with sarcopenic obesity, are at increased risk for treatment-related toxicities from chemotherapy and increased overall mortality. Further investigations into the pathogenesis of muscle wasting among cancer patients are critical, as therapeutic oncologic interventions may inadvertently accelerate muscle catabolism. This review provides an overview of the definitions of low lean body mass, etiologic causes, clinical significance among cancer patients, and potential therapeutic interventions.
The Protein Arginine Methyltransferases 1 and 5 affect Myc properties in glioblastoma stem cells (2019)

Protein Arginine (R) methylation is the most common post-translational methylation in mammalian cells. Protein Arginine Methyltransferases (PRMT) 1 and 5 dimethylate their substrates on R residues, asymmetrically and symmetrically, respectively. They are ubiquitously expressed and play fundamental roles in tumour malignancies, including glioblastoma multiforme (GBM) which presents largely deregulated Myc activity. Previously, we demonstrated that PRMT5 associates with Myc in GBM cells, modulating, at least in part, its transcriptional properties. Here we show that Myc/PRMT5 protein complex includes PRMT1, in both HEK293T and glioblastoma stem cells (GSCs). We demonstrate that Myc is both asymmetrically and symmetrically dimethylated by PRMT1 and PRMT5, respectively, and that these modifications differentially regulate its stability. Moreover, we show that the ratio between symmetrically and asymmetrically dimethylated Myc changes in GSCs grown in stem versus differentiating conditions. Finally, both PRMT1 and PRMT5 activity modulate Myc binding at its specific target promoters. To our knowledge, this is the first work reporting R asymmetrical and symmetrical dimethylation as novel Myc post-translational modifications, with different functional properties. This opens a completely unexplored field of investigation in Myc biology and suggests symmetrically dimethylated Myc species as novel diagnostic and prognostic markers and druggable therapeutic targets for GBM.
Measurements and modeling of the impact of radical recombination on silicon nitride growth in microwave plasma assisted atomic layer deposition (2017)

High material quality silicon nitride thin film deposition by plasma enhanced atomic layer deposition (PEALD) is necessary for many advanced semiconductor device and memory fabrication applications. Understanding film growth mechanism is quite important not only for the device production control but also device performance due to the strong correlation of film growth speed and film chemical property. Nevertheless, predicting film deposition rates, let alone film quality, is difficult as quantitative surface reaction mechanisms are still not well known and the species fluxes that play the central role in film growth are not easy to measure. In this paper, the authors describe how a plasma reactor model for the nitridation step required in PEALD of silicon nitride can be combined with a phenomenological site balance model to predict film growth rate variation with some key process parameters. The relative insensitivity of growth rates to plasma power are explained by competing destruction and regeneration mechanisms for NH3, an important nitrogen source in Si3N4 growth. The model also helps to reveal why H2 can be important.
Endocannabinoids and the gastrointestinal tract. (2006)

In the past centuries, different preparations of marijuana have been used for the treatment of gastrointestinal (GI) disorders, such as GI pain, gastroenteritis and diarrhea. Delta9-tetrahydrocannabinol (THC; the active component of marijuana), as well as endogenous and synthetic cannabinoids, exert their biological functions on the gastrointestinal tract by activating two types of cannabinoid receptors, cannabinoid type 1 receptor (CB1 receptor) and cannabinoid type 2 receptor (CB2 receptor). While CB1 receptors are located in the enteric nervous system and in sensory terminals of vagal and spinal neurons and regulate neurotransmitter release, CB2 receptors are mostly distributed in the immune system, with a role presently still difficult to establish. Under pathophysiological conditions, the endocannabinoid system conveys protection to the GI tract, eg from inflammation and abnormally high gastric and enteric secretion. For such protective activities, the endocannabinoid system may represent a new promising therapeutic target against different GI disorders, including frankly inflammatory bowel diseases (eg, Crohn's disease), functional bowel diseases (eg, irritable bowel syndrome), and secretion- and motility-related disorders.
An Open Architecture for Detecting Earthquakes Using Mobile Devices (2010)

In this paper we will describe an open architecture for detecting earthquakes using the built in accelerometers available in some mobile phones. Although the idea of building a network of accelerometers for this application is not new, we will take an iterative approach starting with a prototype which exhibits some core functionality. Key questions include: what level of sophistication is required to be confident of the architecture and how does this conflict with the limitations of the mobile device and the network used? By examining these questions and evaluating results from our prototype we hope to build further iterations which increase the chances of generating an accurate alert.
High Power Density DC-DC Converter with SiC MOSFETs for Electric Vehicles (2014)

This paper shows the performance evaluation and practical demonstration of a high-power bi-directional DC-DC converter with a power density of 20 kW/l, using 1200V/100A SiC MOSFET modules from CREE. The converter is based on a dual-interleaved topology with hard-switching operating at 75 kHz. To increase the power density, water-cooled magnetic components are used. The experimental results of a 60 kW converter show the potential to increase the operating frequencies up to 100 kHz and beyond in this application.
Exploratory clinical trial of combination wound therapy with a gelatin sheet and platelet-rich plasma in patients with chronic skin ulcers: study protocol (2015)

UMIN000015689.
The Ultra Rapid Differentiation And Identification Of Pathogenic Bacteria Using FT-IR Techniques (1985)

A novel, FT-IR spectroscopic approach to the differentiation and identification of pathogenic microorganisms could be elaborated. The method takes advantage of the Fourier transform mid-infrared spectra of intact microorganisms. Such spectra could be recorded within minutes with high sensitivity and reproducibility when applying a highly standardized experimental procedure prior to ir measurements. By comparing the complete ir spectra - or selected spectral ranges of them - on the basis of their first and second derivatives, differentiation and identification of the microorganisms could be accomplished using cross-correlation algorithms.
Stability of non-linear systems by means of event-triggered sampling algorithms (2013)

In this paper, the problem of feedback control implementation for nonlinear systems is considered. Some conditions for holding the same control input until an event occurs are derived. With respect to classical approaches, where feedback laws are implemented in a periodically fashion, it is suggested new algorithms to use the same control input. By means of these algorithms, some jumps of the control inputs occur and the nonlinear system becomes hybrid, since it has a mixed discrete/continuous dynamics. Under some assumptions, written in terms of Lyapunov functions, two event-based algorithms are suggested for nonlinear systems. The first algorithm is directly based on the variation of the Lyapunov functions. The last event-based algorithm is based on a selection of the input variables to be updated. The results are particularized to linear control systems and illustrated by numerical simulations of linear and nonlinear control systems.
Wireless access mechanisms and architecture definition in the MEDIEVAL project (2011)

Wireless network access and the exchange of multimedia flows over the Internet are becoming more and more pervasive in the everyday life. However, simple technological advances in terms of improved network capacity cannot satisfy the increasing demand of such services, since a paradigm shift from the current Internet architecture is required. The EU FP7 MEDIEVAL project tackles this issue by addressing novel architectural frameworks and viable strategies to efficiently deliver video services in a wireless Internet context. This paper reviews the currently ongoing activities of the project for what concerns wireless access, in particular the identification of useful techniques for the considered access technologies (WLAN and LTE-A) and the general definition of architectural schemes to efficiently support video flows.
Successful recovery of COVID-19 pneumonia in a patient from Colombia after receiving chloroquine and clarithromycin (2020)

Our patient improved significantly. This and other COVID-19 cases are urgently demanding results from clinical trials that support evidence-based therapeutical approaches to this pandemic and the clinical management of patients, especially those at critical care.
Application of DGPS/INS to automobile navigation with latency compensation (2002)

Differential Global Positioning System (DGPS) techniques are frequently used to correct for ranging errors common to two receivers, one of which is at a known position. One such source of error is selective availability (SA). A time delay (latency) is inherent between the generation of pseudo-range corrections and their application by the user, and can result in large residual errors. The data latency of the DGPS correction is a fundamental limitation on DGPS performance accuracies. These corrections can be predicted for relatively short periods of time. In this paper, an innovative methodology is developed which predicts the corrections and compensates the GPS data in real time. It also takes care of any transients in the DGPS data and/or GPS data in real time. This methodology has been applied to automobile navigation and tested in a DGPS/INS system. For these experiments, we used a 12-channel Ashtech XII GPS receiver. The INS system included a 3-axis Hitachi HGA-D fiber-optic gyro, a 3-axis 177 2g accelerometer by NeuwGhent Technology, Inc., and a Vector 2x electronic compass by Precision Navigation.
2004 gender study of the New Jersey Public Relations Society of America (2004)

The purpose of the study was to determine the climate of New Jersey Public Relations Society of America, 2004. The researcher sought to find logical alternatives to the much-touted theory of the "glass ceiling," that many researchers blame for salary differential between the genders. E-mail surveys were distributed to research salary, title, industry, experience, etc. Although NJPRSA men and women have much in common, not everything is mutual. The average male is older and more experienced. Overall female dominance continues in the trade, including in two of the three highest-paying industries. Most respondents were in management positions; however, men occupy more executive level management positions, and females skew toward in-department administration. Respondents distinguished feelings that women often sacrifice career for family, but existence of gender discrimination was nearly unanimously denied. Comments indicate no prejudice against the success of diligent women who prioritize their career. Simply stated, the salary gap results from unequal skill comparison between men and women.
Selective Ionophoric Properties of Anacardic Acid (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSelective Ionophoric Properties of Anacardic AcidK. S. Nagabhushana, S. V. Shobha, and B. RavindranathCite this: J. Nat. Prod. 1995, 58, 5, 807–810Publication Date (Print):May 1, 1995Publication History Published online1 July 2004Published inissue 1 May 1995https://pubs.acs.org/doi/10.1021/np50119a029https://doi.org/10.1021/np50119a029research-articleACS PublicationsRequest reuse permissionsArticle Views245Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Sensomics Mapping and Identification of the Key Bitter Metabolites in Gouda Cheese (2008)

Application of a sensomics approach on the water-soluble extract of a matured Gouda cheese including gel permeation chromatography, ultrafiltration, solid phase extraction, preparative RP-HPLC, and HILIC combined with analytical sensory tools enabled the comprehensive mapping of bitter-tasting metabolites. LC-MS-TOF and LC-MS/MS, independent synthesis, and sensory analysis revealed the identification of a total of 16 bitter peptides formed by proteolysis of caseins. Eleven previously unreported bitter peptides were aligned to beta-casein, among which 6 peptides were released from the sequence beta-CN(57-69) of the N terminus of beta-casein and 2 peptides originated from the C-terminal sequence beta-CN(198-206). The other peptides were liberated from miscellaneous regions of beta-casein, namely, beta-CN(22-28), beta-CN(74-86), beta-CN(74-77), and beta-CN(135-138), respectively. Six peptides were found to originate from alpha(s1)-casein and were shown to have the sequences alpha(s1)-CN(11-14), alpha(s1)-CN(56-60), alpha(s1)-CN(70/71-74), alpha(s1)-CN(110/111-114), and alpha(s1)-CN(135-136). Sensory evaluation of the purified, synthesized peptides revealed that 12 of these peptides showed pronounced bitter taste with recognition thresholds between 0.05 and 6.0 mmol/L. Among these peptides, the decapeptide YPFPGPIHNS exhibited a caffeine-like bitter taste quality at the lowest threshold concentration of 0.05 mmol/L.
ChemInform Abstract: SYNTHESIS OF POLYSACCHARIDES. 9. POLYCONDENSATION OF 2,3,6,2′,3′,4′‐HEXA‐O‐ACETYL‐α‐MALTOSYL BROMIDE (1978)

Abstract Aus dem α‐Maltosyl‐ethyl‐sulfid (I) wird über die Verbindungen (II) und (III) das Bromid (IV) hergestellt, das 3 ‐ 5 Min. in Nitromethan mit Quecksilbercyanid erhitzt wird.
Le Syndrome Dysgénésique et Respiratoire du Porc (SDRP) : Données actuelles sur une nouvelle maladie (1993)

Porcine reproductive and respiratory syndrome (prrs) current knowledges on a new disease. Porcine Reproductive and Respiratory Syndrome (PRRS) is a new disease of swine due to a new virus. The disease has been first described in the United States of America in 1987. Today, it is present in nearly all the pig producing countries. Symptomatology is very variable, mainly consisting of reproductive disorders (abortion, stillbirth and piglet mortality) and influenza-like syndrome (lack of appetite, slight fever and coughing). The causative agent belongs to the Arterivirus group which also comprises the Equine Arteritis Virus. All these envelopped and RNA’s viruses are able to replicate in macrophages and cross the placental barrier leading to the infection of the fetuses. Since the Arteriviruses are antigenically extremely variable, they are able to persist for a long time within the infected animals although the laters had previously and normally developed a specific immune response : in addition these viruses are highly suspected of being responsible for recurrent immunosuppressive effects. The spreading of the PRRS virus mainly occurres by direct contact between a susceptible animal and an infected one. However, the airborne spreading of the virus on short distances is now well documented. These epidemiological data explain the rapid spreading of the disease inside the high pig density areas. Moreover, the long term viral circulation within the infected herds would compromise any tentative of disease contrôle.
ChemInform Abstract: Synthesis and Structure Determination of Some Oxadiazole‐2‐thione and Triazole‐3‐thione Galactosides. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Carbonic anhydrase modulation of emotional memory. Implications for the treatment of cognitive disorders (2020)

Carbonic anhydrases (CAs, EC 4.2.1.1) are metalloenzymes which use CO<sub>2</sub> as substrate, catalysing its interconversion to bicarbonate and a proton. In humans 15 CAs are expressed, 12 of which are catalytically active: the cytosolic CA I-III, VII, XIII, the membrane-bound CA IV, the mitochondrial CA VA and VB, the secreted CA VI, and the transmembrane CA IX, XII, XIV. Nine isoforms are present in the mammalian brain. Evidence supporting that CA inhibitors impair memory in humans has come from studies on topiramate and acetazolamide during acute high-altitude exposure. In contrast, administration of CA activators in animal models enhances memory and learning. Here we review the involvement of selective CA inhibition/activation in cognition-related disorders. CAs may represent a crucial family of new targets for improving cognition as well as in therapeutic areas, such as phobias, obsessive-compulsive disorder, generalised anxiety, and post-traumatic stress disorders, for which few efficient therapies are available.
Outcome after acute myocardial infarction: a comparison of patients seen by cardiologists and general physicians (2004)

Access to a cardiologist is associated with better survival compared to no access to a cardiologist among a cohort of patients already admitted with AMI. This effect is mainly due to the more frequent use of effective medicines by the group referred to cardiologists. Hospitals may improve survival by improving access to effective medicines and by coordinating care between cardiologists and general physicians.
Metallic Printing: Metallic Architectures from 3D‐Printed Powder‐Based Liquid Inks (Adv. Funct. Mater. 45/2015) (2015)

A new method for 3D printing complex metallic structures is presented by R. N. Shah and co-workers on page 6985. Particle-laden liquid inks comprised of metals, metal oxides, and other metal compound powders are 3D printed into complex solid architectures. The printed objects are then thermochemically processed in a reducing hydrogen atmosphere, leading to a metallic structure maintaining the structural integrity of the printed form, with no warping or cracking.