gebhart/patrepeval huggingface dataset:
Astrometric observations of comets and minor planets (1991)

Comets and planet crossing asteroids are observed so that accurate positions can be determined. The observations are made with the Palomar 1.5 m telescope equipped with a CCD array. The combination of telescope and detector is quite effective at recording faint comets and minor planets. This proves useful for early acquisition of comets and asteroids returning for a new opposition. The resulting positions permit accurate orbits to be determined and allow the properties of the comets and asteroids to be measured by other observers using a variety of techniques. Recoveries and other notable observations of comets and planet crossing asteroids observed during the past years are discussed.
ASSESSING THE RELATIONSHIP BETWEEN MONOALLELIC PARK2 MUTATIONS AND PARKINSON’S RISK (2020)

ABSTRACT Biallelic PARK2 (Parkin) mutations cause autosomal recessive Parkinson’s (PD); however, the role of monoallelic PARK2 mutations as a risk factor for PD remains unclear. We investigated the role of single heterozygous PARK2 mutations in three large independent case-control cohorts totalling 10,858 PD cases and 8,328 controls. Overall, after exclusion of biallelic carriers, single PARK2 mutations were more common in PD than controls conferring a &gt;1.5-fold increase in risk of PD (P=0.035), with meta-analysis (19,574 PD cases and 468,488 controls) confirming increased risk (OR=1.65, P=3.69E-07). Carriers were shown to have significantly younger ages at onset compared to non-carriers (NeuroX: 56.4 vs . 61.4 years; Exome: 38.5 vs . 43.1 years). Stratifying by mutation type, we provide preliminary evidence for a more pathogenic risk profile for single PARK2 copy number variant (CNV) carriers compared to single nucleotide variant carriers. Studies that did not assess biallelic PARK2 mutations or consist of predominantly early-onset cases may be biasing these estimates, and removal of these resulted in a loss of association (OR=1.23, P=0.614; n=4). Importantly, when we looked for additional CNVs in 30% of PD cases with apparent monoallellic PARK2 mutations we found that 44% had biallelic mutations suggesting that previous estimates may be influenced by cryptic biallelic mutation status. While this study supports the association of single PARK2 mutations with PD, it highlights confounding effects therefore caution is needed when interpreting current risk estimates. Together, we demonstrate that comprehensive assessment of biallelic mutation status is essential when elucidating PD risk associated with monoallelic PARK2 mutations.
Serial Metabolic Evaluation of Perihematomal Tissues in the Intracerebral Hemorrhage Pig Model (2019)

This study highlights the potential of MRS to probe salvageable tissues within the perihematoma in the sub-acute phase of ICH. Altered metabolites within the PHE and ATNE regions in addition to edema and hematoma volumes were explored as possible markers for tissue recovery. Perihematomal tissue with PHE demonstrated a more reversible injury compared to the tissue adjacent to the injury without edema, suggesting a potentially beneficial role of edema.
Static secondary ion mass spectrometric investigation of the surface chemistry of organic plasma-deposited films created from oxygen-containing precursors. 3. Multivariate statistical modeling (1993)

Partial least squares (PLS) multivariate statistical models were developed to predict the surface composition and chemistry of a set of model homopolymers based on their static SIMS fragmentation patterns. In the calibration or model-building step, the positive and negative ion static SIMS spectra of different classes of model homopolymers were related to specific chemical attributes of the polymers. The models were then used to examine the surface chemistry of oxygen-containing plasma-deposited films prepared from a variety of precursors. PLS models were developed to predict the surface oxygen concentration and H/C ratios. The results obtained from the PLS models were compared with experimental results.
Antioxidant Vitamin C Prevents Decline in Endothelial Function during Sitting (2015)

Three hours of sitting resulted in impaired SFA FMD. Antioxidant Vitamin C prevented the decline in SFA FMD, suggesting that oxidative stress may contribute to the impairment in endothelial function during sitting.
Next generation oncolytic viruses expressing PADI1 and TIMP2 exhibit anti-tumor activity against melanoma in nude and humanized mouse models (2023)

Immunotherapy of metastatic melanoma (MM) has vastly improved the longevity of only a minority of patients. To broaden the repertoire of agents against MM, we investigated the effectiveness of locally interrupting tumor blood endothelial cell proliferation and angiogenesis, arginine deprivation, or both on the growth of melanoma by constructing and characterizing the effectiveness of four oncolytic adenoviruses. ONCOS-207 (which expressed tissue inhibitor of metalloprotease type 2 [TIMP2]), ONCOS-209 (which expressed peptidyl arginine deiminase [PADI1]), and ONCOS-210 and ONCOS-212 (which expressed both TIMP2 and PADI1) exhibited oncolytic activity against four melanoma cell lines <i>in vitro</i>. ONCOS-212 treatments significantly inhibited tumor growth in an A2058 tumor model in nude mice compared with vehicle control. The inhibitory effects of the two transgenes of ONCOS-212 on tumor growth appeared to be synergistic. These viruses also significantly inhibited tumor growth in a humanized NOG model of melanoma (A2058 xenograft). All viruses significantly increased the percentage of activated CD8+ T cells in the tumor-infiltrating lymphocytes. The abscopal effect of ONCOS-212 treatments in the A2058 tumor challenge model in hNOG mice supports the hypothesis that the human immune response contributes to the anti-tumor activity of ONCOS-212. These results support the further development of ONCOS-212 for cancer treatment.
Adaptive feed array compensation system for reflector antenna surface distortion (1989)

The feasibility of a closed-loop adaptive feed array system for compensating reflector surface deformations is investigated. The performance characteristics (gain, sidelobe, level, pointing, etc.) of large communication antenna systems degrade as the reflector surface distorts mainly due to thermal effects from a varying solar flux. The compensating systems described here can be used to maintain the design performance characteristics independent of thermal effects on the reflector surface. The proposed compensating system uses the concept of conjugate field matching to adjust the feed array complex excitation coefficients. To demonstrate the concept a simulated distorted reflector case is presented with several element patterns. >
Surface plasmon resonance imaging for parallelized detection of protein biomarkers (2009)

We report a novel high-throughput surface plasmon resonance (SPR) biosensor for rapid and parallelized detection of protein biomarkers. The biosensor is based on a high-performance SPR imaging sensor with polarization contrast and internal referencing which yields a considerably higher sensitivity and resolution than conventional SPR imaging systems (refractive index resolution 2 &times; 10<sup>-7</sup> RIU). We combined the SPR imaging biosensor with microspotting to create an array of antibodies. DNA-directed protein immobilization was utilized for the spatially resolved attachment of antibodies. Using Human Chorionic Gonadotropin (hCG) as model protein biomarker, we demonstrated the potential for simultaneous detection of proteins in up to 100 channels.
A Randomized Trial of Chemoradiotherapy and Chemotherapy after Resection of Pancreatic Cancer (2004)

Adjuvant chemotherapy has a significant survival benefit in patients with resected pancreatic cancer, whereas adjuvant chemoradiotherapy has a deleterious effect on survival.
Hyaline Articular Matrix Formed by Dynamic Self-Regenerating Cartilage and Hydrogels (2016)

Injuries to the articular cartilage surface are challenging to repair because cartilage possesses a limited capacity for self-repair. The outcomes of current clinical procedures aimed to address these injuries are inconsistent and unsatisfactory. We have developed a novel method for generating hyaline articular cartilage to improve the outcome of joint surface repair. A suspension of 10(7) swine chondrocytes was cultured under reciprocating motion for 14 days. The resulting dynamic self-regenerating cartilage (dSRC) was placed in a cartilage ring and capped with fibrin and collagen gel. A control group consisted of chondrocytes encapsulated in fibrin gel. Constructs were implanted subcutaneously in nude mice and harvested after 6 weeks. Gross, histological, immunohistochemical, biochemical, and biomechanical analyses were performed. In swine patellar groove, dSRC was implanted into osteochondral defects capped with collagen gel and compared to defects filled with osteochondral plugs, collagen gel, or left empty after 6 weeks. In mice, the fibrin- and collagen-capped dSRC constructs showed enhanced contiguous cartilage matrix formation over the control of cells encapsulated in fibrin gel. Biochemically, the fibrin and collagen gel dSRC groups were statistically improved in glycosaminoglycan and hydroxyproline content compared to the control. There was no statistical difference in the biomechanical data between the dSRC groups and the control. The swine model also showed contiguous cartilage matrix in the dSRC group but not in the collagen gel and empty defects. These data demonstrate the survivability and successful matrix formation of dSRC under the mechanical forces experienced by normal hyaline cartilage in the knee joint. The results from this study demonstrate that dSRC capped with hydrogels successfully engineers contiguous articular cartilage matrix in both nonload-bearing and load-bearing environments.
Homoclinic and heteroclinic solutions to a hepatitis C evolution model (2018)

Abstract Homoclinic and heteroclinic solutions to a standard hepatitis C virus (HCV) evolution model described by T. C. Reluga, H. Dahari and A. S. Perelson, ( SIAM J. Appl. Math ., 69 (2009), pp. 999–1023) are considered in this paper. Inverse balancing and generalized differential techniques enable derivation of necessary and sufficient existence conditions for homoclinic/heteroclinic solutions in the considered system. It is shown that homoclinic/heteroclinic solutions do appear when the considered system describes biologically significant evolution. Furthermore, it is demonstrated that the hepatitis C virus evolution model is structurally stable in the topological sense and does maintain homoclinic/heteroclinic solutions as diffusive coupling coefficients tend to zero. Computational experiments are used to illustrate the dynamics of such solutions in the hepatitis C evolution model.
Hemoglobin A2Honai (α2δ290(F6)GLU—VAL): A new Delta Chain Variant (1985)

A new slow-moving variant of hemoglobin(Hb) A2, designated as Hb A2 Honai, was found to have an amino acid substitution of valine for glutamic acid at position 90(F6) in the delta chain. Hb A2 Honai comprised 0.84% of total hemoglobin. Hb A2 and Hb A were estimated to be 1.30% and 97.85%, respectively. Hb A2 Honai was observed in 4 members of a family in 3 generations. No hematologic abnormalities were associated with Hb A2 Honai.
ChemInform Abstract: Metabolites of Microorganisms. Part 257. (3S,5R,6E,8E)‐Deca‐6,8‐diene‐ 1,3,5‐triol, a New Metabolite from Streptomyces fimbriatus (Millard et Burr 1926). (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A TGF-?-inducible cell adhesion molecule, ?ig-h3, is downregulated in melorheostosis and involved in osteogenesis (2000)

Melorheostosis is a rare bone disease characterized by linear hyperostosis and associated soft tissue abnormalities. The skin overlying the involved bone lesion is often tense, shiny, erythematous, and scleodermatous. In order to look for genes differentially expressed between the normal and involved skin, we cultured skin fibroblasts from the skin lesions of several afflicted patients, and identified differentially expressed genes by reverse dot-blot hybridization. We found that the genes human TGF-beta-induced gene product (betaig-h3), osteoblast-specific factor 2, osteonectin, fibronectin, and type I collagen were all downregulated in the affected skin fibroblasts, with betaig-h3 the most significantly affected. The expression of betaig-h3 was induced by TGF-beta in both affected and normal fibroblasts. In an effort to determine the mechanism of bone and skin abnormalities in melorheostosis, we made recombinant betaig-h3. Both immobilized and soluble recombinant betaig-h3 proteins with or without an RGD motif inhibited bone nodule formation of osteoblasts in vitro. Taken together, our results suggest that altered expression of several adhesion proteins may contribute to the development of hyperostosis and concomitant soft tissue abnormalities of melorheostosis, with betaig-h3 in particular playing an important role in osteogenesis.
Fast horizontal electrophoresis. I. Isoelectric focusing and polyacrylamide gel electrophoresis using PhastSystem™ (1988)

PhastSystem, an integrated system for horizontal electrophoresis and isoelectric focusing in small gels, including automated staining and destaining, is described. Buffers for electrophoresis are supplied to the gel from buffer strips made of agarose. The separation bed is cooled by Peltier elements. All conditions of significance to the results, both during separation and development, are controlled by a microprocessor. For separation, nine programs are available, each with 9 steps; for development, there are nine programs with 20 steps each. In this paper, we also report results using PhastSystem for purity checking and characterization of monoclonal antibodies after affinity chromatography and also for determining their digestion rate with papain.
ChemInform Abstract: Catalytic Performance of Ruthenium‐Supported Ionic‐Liquid Catalysts in Sustainable Synthesis of Macrocyclic Lactones. (2010)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Implementing Fair Non-repudiable Interactions with Web Services (2006)

The use of open, Internet-based communications for business-to-business (B2B) interactions requires accountability for and acknowledgment of the actions of participants. Accountability and acknowledgment can be achieved by the systematic maintenance of an irrefutable audit trail to render the interaction non-repudiable. To safeguard the interests of each party, the mechanisms used to meet this requirement should ensure fairness. That is, misbehaviour should not disadvantage well-behaved parties. Despite the fact that Web services are increasingly used to enable B2B interactions, there is currently no systematic support to deliver such guarantees. This paper introduces a flexible framework to support fair non-repudiable B2B interactions based on a trusted delivery agent. A Web services implementation is presented. The role of the delivery agent can be adapted to different end user capabilities and to meet different application requirements.
Mahabbah (2021)

Would the world be better with more empathy? If so, why not simply engineer society to be more empathetic? In this work of philosophical short story fiction, Jacqueline is a scientist who invents a virus that she says changes people for the better. By editing genes and changing hormone levels it makes people more empathetic and compassionate towards others. She calls it Mahabbah and she wants the help of her friend Aziz to continuing human trials and release it into the world. Aziz agrees to also test the virus and determines it does perform as advertised. After being infected, Aziz is more sympathetic, and more willing to help others. When Aziz goes to Jacqueline’s office, he finds that she is being detained and her office is being quarantined. Jacqueline gets a message to Aziz who goes to her house, gets the virus, and releases a transferable version in the airport. It works. Over the next few months wars end and world peace takes hold. Jacqueline is released from quarantine months later and meets up with Aziz, and their friendship is strengthened in a new world.
Generalized social anxiety disorder and avoidant personality disorder: structural analysis and treatment outcome (2007)

There has been considerable controversy about whether generalized social phobia (GSP) and avoidant personality disorder (APD) are redundant diagnostic categories. In light of the ongoing controversy, more data are needed to help determine whether GSP and APD are independent constructs. Data were obtained from 335 people seeking treatment for GSP at a two site clinical trial. Indicators of GSP and APD were obtained along with assessments of demographic factors, level of functioning, and indicators of related psychopathology. Confirmatory factor analyses of indicators of GSP and APD suggested a somewhat better fit for a two-factor solution. Comparisons of GSP patients with and without APD suggested that in addition to having more severe social phobia symptoms, patients with APD were more depressed on a self-report measure and had more functional impairment, thereby suggesting potential utility of the diagnostic category of APD. Furthermore, the presence of APD predicted treatment response, in that patients with APD had more change early in treatment than those without APD. APD and GSP remain highly related constructs, and different aspects of these data support and dispute the utility of the diagnosis of APD in GSP. Possible new directions in conceptualizing APD are discussed.
Superacidified Reaction of Sulfides and Esters for the Direct Synthesis of Sulfonium Derivatives (1998)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTSuperacidified Reaction of Sulfides and Esters for the Direct Synthesis of Sulfonium DerivativesKenji Miyatake, Kimihisa Yamamoto, Kazuhisa Endo, and Eishun TsuchidaView Author Information Department of Polymer Chemistry, Advanced Research Institute for Science and Engineering, Waseda University, Tokyo 169-8555, Japan Cite this: J. Org. Chem. 1998, 63, 21, 7522–7524Publication Date (Web):September 26, 1998Publication History Received12 March 1998Published online26 September 1998Published inissue 1 October 1998https://pubs.acs.org/doi/10.1021/jo980473chttps://doi.org/10.1021/jo980473cbrief-reportACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views1945Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Alkyls,Hydrocarbons,Organic compounds,Salts,Sulfides Get e-Alerts
Multistep autoregressive reconstruction of seismic records (2007)

Abstract Linear prediction filters in the f-x domain are widely used to interpolate regularly sampled data. We study the problem of reconstructing irregularly missing data on a regular grid using linear prediction filters. We propose a two-stage algorithm. First, we reconstruct the unaliased part of the data spectrum using a Fourier method (minimum-weighted norm interpolation). Then, prediction filters for all the frequencies are extracted from the reconstructed low frequencies. The latter is implemented via a multistep autoregressive (MSAR) algorithm. Finally, these prediction filters are used to reconstruct the complete data in the f-x domain. The applicability of the proposed method is examined using synthetic and field data examples.
Cardiac Quantitative Susceptibility Mapping for Mitral Annular Calcium: Validation using Quantitative Calcium Scoring on Computed Tomography (2023)

This study tested cardiac MRI cardiac quantitative susceptibility mapping (QSM) for measurement of mitral annular calcification (MAC) using the reference of computed tomography (CT). QSM entailed a free-breathing ECG-triggered multi-echo 3D GRE sequence with diaphragmatic navigation via ECG-gating (1D respiratory navigator, 4mm window, acquisition time ~7 minutes, navigator efficiency 36%, spatial resolution 1.5&amp;times;1.5&amp;times;5mm3). Among 24 patients undergoing MRI and CT (mean 3.9&amp;plusmn;3.4 months), annular susceptibility decreased stepwise (p&amp;lt;0.001) and R2* increased (p&amp;lt;0.05) among patients stratified by CT mitral annular calcium score. Both QSM (AUC=0.950, p=0.005) and R2* (AUC=0.938, p=0.007) yielded excellent diagnostic performance for advanced mitral annular calcification on CT.
[Survival benefits of and indications for extended surgery for advanced gastric cancer]. (2001)

The surgical management of locally advanced gastric cancer remains controversial. It is also unclear whether the postoperative survival rate could be improved by extended lymph node dissection. The aim of this paper is to determine the survival benefit of and the indications for extended surgery. Lymph node metastasis in the paraaortic area frequently occurs in locally advanced cardiac cancer. In our previous studies, the paraaortic lymph nodes above and below the left renal vein were confirmed to be the terminal destination of lymphatic flow in the upper abdominal cavity. Paraaortic lymph node dissection is essential for curarive resection in some cases of advanced gastric cancer. The 5-year survival rate in patients who undergo paraaortic lymph node dissection is nearly 15% according to the literature. Patients with metastasis of the paraaortic lymph nodes on only one side and with fewer than four involved nodes clearly benefit from paraaortic lymph node dissection. It is indicated in cases with metastasis or suspected metastasis of the left or right cardiac lymph node or N2 lymph node station. There is little survival benefit from combined resection of involved organs (T4 disease) and it should only be performed in a select group of patients. Extended surgery for locally advanced gastric cancer, however, is feasible and has acceptable operative morbidity and mortality rates.
Proposal of regional application to confirm and strengthen the connection between residents (2020)

In this research, the object is to develop an application as a new communication design so that the connection within the local community can be confirmed and strengthened, and to promote communication between residents. Specifically, we develop three application, “Kizuna point systems,” “Regional maps,” and “Jintori games,” and verify whether using them affect the connections between residents. In this paper, we discuss the research concept, systems, experiment, and future prospects.