gebhart/patrepeval huggingface dataset:
Anti-Bacterial Effects of Poly-N-Acetyl-Glucosamine Nanofibers in Cutaneous Wound Healing: Requirement for Akt1 (2011)

sNAG treatment causes increased expression of both α- and β-type defensins in endothelial cells and β-type defensins in keratinocytes. Pharmacological inhibition and shRNA knockdown implicates Akt1 in sNAG-dependent defensin expression in vitro, an activity also shown in an in vivo wound healing model. Importantly, sNAG treatment results in increased kinetics of wound closure in wild type animals. sNAG treatment decreases bacterial infection of cutaneous wounds infected with Staphylococcus aureus in wild type control animals but not in similarly treated Akt1 null animals. Furthermore, sNAG treatment of S. aureus infected wounds show an increased expression of β-defensin 3 which is required for sNAG-dependent bacterial clearance. Our findings suggest that Akt1 is involved in the regulation of defensin expression and the innate immune response important for bacterial clearance. Moreover, these findings support the use of sNAG nanofibers as a novel method for enhancing wound closure while simultaneously decreasing wound infection.
Update in the pharmaceutical therapy of the irritable bowel syndrome (2004)

The therapeutic management of the irritable bowel syndrome (IBS) is ineffective and not satisfying either patients or practitioners. Research in functions of the enteric nervous system and its interaction with the central nervous system is the basis for the development of emerging pharmaceuticals in therapy of the IBS. These pharmaceuticals include agents such as opioid agonists, psychotropic agents and particularly serotonin receptor modulators. These novel pharmaceuticals aim to provide a more comprehensive approach in the therapy of the IBS and will serve both patients and practitioners. So far, the US Food and Drug Administration has approved two agents specifically for the treatment of the IBS, both belonging to the group of serotonin receptor modulators. However, questions remain whether a single therapy is sufficient in the management of IBS because this disease is influenced by biological and psychological as well as cultural and social factors.
Simulation of Guided Waves Propagation in Axial Transmission Measurements in Human Radius (2007)

This paper is a brief review of the axial transmission measurements methodology. Theoretical background and description of the methodology is presented. Simulations made to verify some of the statements found in the scientific literature about the subject matter are described. Simulation performed were meant to be a basis for specifying parameters of the experimental set up to be used in the future. Three dimensional finite difference code was used to simulate wave propagation in human radius. Two models have been prepared to compare the results. One was an idealized geometry of the diaphysis of human radius and second was a reconstructed anatomical geometry from scans acquired with Computed Tomography (CT). Conclusions about the wave propagation character and feasibility of low frequency measurements in medical diagnostics are discussed.
Network Latency, Jitter and Loss (2006)

This chapter contains sections titled: The Relevance of Latency, Jitter and Loss Sources of Latency, Jitter and Loss in the Network Network Control of Lag, Jitter and Loss Measuring Network Conditions References
Regulation of protein synthesis in rabbit reticulocyte lysates by the heme-regulated protein kinase: Inhibition of interaction of Met-tRNA f Met binding factor with another initiation factor in formation of Met-tRNA f Met ·40S ribosomal subunit complexes (1978)

Protein synthesis in reticulocytes and their lysates is regulated by heme. In heme deficiency a heme-regulated translational inhibitor (HRI) that blocks initiation of polypeptide chains is activated. HRI is a protein kinase (ATP: protein phosphotransferase, EC 2.7.1.37) that specifically phosphorylates the 38,000-dalton subunit of the Met-tRNA(f) (Met) binding factor (IF), which forms a ternary complex with Met-tRNA(f) (Met) and GTP, a finding that suggests that the inhibition by HRI involves the phosphorylation of IF. We have investigated the effect of HRI in the partial reactions of protein chain initiation in which the IF-promoted binding of Met-tRNA(f) (Met) to 40S ribosomal subunits is enhanced by another initiation factor [ternary complex dissociation factor (TDF)] and AUG. The results show that HRI at very low concentrations markedly inhibits the binding of Met-tRNA(f) (Met) to 40S subunits. The inhibitory effect of HRI requires ATP. Under these conditions HRI phosphorylates only the 38,000-dalton subunit of IF. The TDF preparations not only promote the binding of the ternary complex to 40S subunits but also promote the dissociation of the ternary complex in the presence of 5 mM Mg(2+) at 0 degrees . The preincubation of purified IF alone with low concentrations of HRI and ATP does not significantly affect its capacity to form the ternary complex; however, the TDF-promoted dissociation of the ternary complex is inhibited. The nonhydrolyzable analog adenosine 5'-[beta,gamma-imido]triphosphate does not substitute for ATP. These findings suggest that phosphorylation causes a conformational modification in IF, which results in inhibition of the interaction between the ternary complex and TDF that is required for the binding of the ternary complex to 40S subunits.
Structural characterization of ultrathin Cr-doped ITO layers deposited by double-target pulsed laser ablation (2011)

In this paper we report on the growth and structural characterization of very thin (20 nm) Cr-doped ITO films, deposited at room temperature by double-target pulsed laser ablation on amorphous silica substrates. The role of Cr atoms in the ITO matrix is carefully investigated with increasing doping content by transmission electron microscopy (TEM). Selected-area electron diffraction, conventional bright field and dark field as well as high-resolution TEM analyses, and energy dispersive x-ray spectroscopy demonstrate that (i) crystallization features occur despite the low growth temperature and small thickness, (ii) no chromium or chromium oxide secondary phases are detectable, regardless of the film doping levels, (iii) the films crystallize as crystalline flakes forming large-angle grain boundaries; (iv) the observed flakes consist of crystalline planes with local bending of the crystal lattice. Thickness and compositional information about the films are obtained by Rutherford back-scattering spectrometry. Results are discussed by considering the combined effects of growth temperature, smaller ionic radius of the Cr cation compared with the trivalent In ion, doping level, film thickness, the double-target doping technique and peculiarities of the pulsed laser deposition method.
Rapidly quantifying drug sensitivity of dispersed and clumped breast cancer cells by mass profiling (2012)

Live cell mass profiling is a promising new approach for rapidly quantifying responses to therapeutic agents through picogram-scale changes in cell mass over time. A significant barrier in mass profiling is the inability of existing methods to handle pleomorphic cellular clusters and clumps, which are more commonly present in patient-derived samples or tissue cultures than are isolated single cells. Here we demonstrate automated Live Cell Interferometry (LCI) as a rapid and accurate quantifier of the sensitivity of single cell and colony-forming human breast cancer cell lines to the HER2-directed monoclonal antibody, trastuzumab (Herceptin). The relative sensitivities of small samples (<500 cells) of four breast cancer cell lines were determined tens-to-hundreds of times faster than is possible with traditional proliferation assays. These LCI advances in clustered sample assessment and speed open up the possibility for therapeutic response testing of patient-derived solid tumor samples, which are viable only for short periods ex vivo and likely to be in the form of cell aggregates and clusters.
Fluorination reactions in microreactors (2008)

The DAST-mediated conversion of a range of alcohols to the corresponding fluorides in a microstructured device is described. This safe, practical fluorination method will facilitate reactions currently challenging on large scale.
<title>Influence of process route on mechanical and sensing performance of fiber Bragg grating optical sensors</title> (1999)

Fiber Bragg gratings were fabricated in commercially available photosensitive optical fiber, using a phase mask and UV irradiation at 245.6 nm and 266 nm. Prior to irradiation, the acrylate buffer coating was removed from the fiber using different stripping methods: chemical solvent, hot-acid and heat. The tensile strength of the fiber was measured at various stages of the fabrication process: with buffer coating intact, with the buffer coating chemically removed, and following UV irradiation. A Fabry-Perot demodulation system monitored the wavelength shift of the reflected peak from the FBG during the tensile loading, from which the strain to failure of FBG sensors has been determined. Each set of strength data has been plotted by applying the Weibull statistics. The results indicate that the removal of the buffer coating degrades the strength of optical fibers. The Weibull analysis indicates two failure mechanisms. Bare fibers show a high Weibull modulus, above 24, if no mechanical flaws have been introduced, while the fibers with surface flaws fail at low stress with the Weibull modulus as low as 2.78. UV irradiation has been found to further reduce the fiber strength. Most irradiated fibers fractured within the sensor gauge length. It is believed that a stress concentration or surface stress is induced by the UV energy, which results in mechanical degradation.
Solvomercuration-demercuration. 10. Oxymercuration-demercuration of olefins with the mercuric salts: acetate, trifluoroacetate, nitrate, and methanesulfonate (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolvomercuration-demercuration. 10. Oxymercuration-demercuration of olefins with the mercuric salts: acetate, trifluoroacetate, nitrate, and methanesulfonateHerbert C. Brown, Philip J. Geoghegan Jr., and Joseph T. KurekCite this: J. Org. Chem. 1981, 46, 19, 3810–3812Publication Date (Print):September 1, 1981Publication History Published online1 May 2002Published inissue 1 September 1981https://pubs.acs.org/doi/10.1021/jo00332a009https://doi.org/10.1021/jo00332a009research-articleACS PublicationsRequest reuse permissionsArticle Views502Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: Pentadienylzirconium Compounds: Easily Accessible New Reagents for Selective Pentadienylation Reactions. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Preface (2009)

ADVERTISEMENT RETURN TO BOOKPREVPrefaceNEXTPrefaceCharles A. WilkieCharles A. WilkieDepartment of Chemistry Marquette University P.O. Box 1881 Milwaukee, WI 53201-1881More by Charles A. Wilkie, Alexander B. MorganAlexander B. MorganMultiscale Composites and Polymers Division University of Dayton Research Institute 300 College Park Dayton, OH 45469-0160More by Alexander B. Morgan, and Gordon L. NelsonGordon L. NelsonCollege of Science Florida Institute of Technology 150 West University Boulevard Melbourne, FL 32901-6975More by Gordon L. NelsonDOI: 10.1021/bk-2009-1013.pr001 This publication is free to access through this site. Learn MorePublication Date (Print):April 27, 2009Publication History Published online23 July 2009Published inprint 27 April 2009Request reuse permissions Copyright © 2009 American Chemical Society. This publication is available under these Terms of Use. Fire and Polymers Vpp xi-xiiACS Symposium SeriesVol. 1013ISBN13: 9780841269880eISBN: 9780841224896Chapter Views535Citations-LEARN ABOUT THESE METRICSChapter Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (189 KB) Get e-Alerts
Effectiveness of gelatine and chitosan spray coating for extending shelf life of vacuum‐packaged beef (2021)

Summary The effects of applying gelatine (10%) and chitosan (1%) as spray coatings to extend the shelf life of vacuum‐packaged beef was studied and compared against uncoated vacuum‐packaged beef for up to 21 days. The impact of edible coatings on the water‐holding properties of vacuum‐packaged beef was investigated by LF‐NMR together with physicochemical, microbiological and sensorial assessments. Chitosan coating significantly reduced lipid oxidation by ~30% to 36% and inhibited the growth of lactic acid bacteriaby ~ 1–2 log cfu compared to purge collected from uncoated and gelatine coated samples. It did not negatively affect the meat pH, tenderness and colour, and exhibited significantly higher sensorial acceptance compared to beef coated with gelatine. Both coatings were not effective in reducing purge loss in vacuum‐packaged meat as the storage time increased. This study suggests that chitosan spray coating could be easily adapted to industrial plant settings as an antioxidant and antimicrobial application before carrying out meat vacuum packaging operation.
Integrated AlGaInAs-silicon evanescent racetrack laser and photodetector (2007)

Recently, AlGaInAs-silicon evanescent lasers have been demonstrated as a method of integrating active photonic devices on a silicon based platform. This hybrid waveguide architecture consists of III-V quantum wells bonded to silicon waveguides. The self aligned optical mode leads to a bonding process that is manufacturable in high volumes. Here give an overview of a racetrack resonator laser integrated with two photo-detectors on the hybrid AlGaInAs-silicon evanescent device platform. Unlike previous demonstrations of hybrid AlGaInAs-silicon evanescent lasers, we demonstrate an on-chip racetrack resonator laser that does not rely on facet polishing and dicing in order to define the laser cavity. The laser runs continuous-wave (c.w.) at 1590 nm with a threshold of 175 mA, has a maximum total output power of 29 mW and a maximum operating temperature of 60 C. The output of this laser light is directly coupled into a pair of on chip hybrid AlGaInAs-silicon evanescent photodetectors used to measure the laser output.
Overground walking speed changes when subjected to body weight support conditions for nonimpaired and post stroke individuals (2010)

The BWS training environment results in decreased self-selected walking speed in nonimpaired individuals, however self-selected overground walking speed is facilitated when provided with a small percentage of body weight support for people post-stroke.
Trehalose 6‐phosphate promotes seed filling by activating auxin biosynthesis (2020)

Plants undergo several developmental transitions during their life cycle. One of these, the differentiation of the young embryo from a meristem-like structure into a highly specialized storage organ, is believed to be controlled by local connections between sugars and hormonal response systems. However, we know little about the regulatory networks underpinning the sugar-hormone interactions in developing seeds. By modulating the trehalose 6-phosphate (T6P) content in growing embryos of garden pea (Pisum sativum), we investigate here the role of this signaling sugar during the seed-filling process. Seeds deficient in T6P are compromised in size and starch production, resembling the wrinkled seeds studied by Gregor Mendel. We show also that T6P exerts these effects by stimulating the biosynthesis of the pivotal plant hormone, auxin. We found that T6P promotes the expression of the auxin biosynthesis gene TRYPTOPHAN AMINOTRANSFERASE RELATED2 (TAR2), and the resulting effect on auxin concentrations is required to mediate the T6P-induced activation of storage processes. Our results suggest that auxin acts downstream of T6P to facilitate seed filling, thereby providing a salient example of how a metabolic signal governs the hormonal control of an integral phase transition in a crop plant.
Stereoselective Synthesis of (3R)‐3,4‐Dihydro‐6,8‐dimethoxy‐3‐undecyl‐ 1H‐[2]benzopyran‐1‐one and Derivatives, Metabolites from Ononis natrix (2003)

Abstract A short stereoselective synthesis of (3 R )‐3,4‐dihydro‐6,8‐dimethoxy‐3‐undecyl‐1 H ‐[2]benzopyran‐1‐one and derivatives isolated from Ononis natrix has been described. Condensation of dodecanoyl chloride with 3,5‐dimethoxyhomophthalic acid afforded 6,8‐dimethoxy‐3‐undecylisocoumarin 3 , which, on sequential saponification and esterification, yielded the keto ester 5 . Enantioselective reduction of 5 with TarB‐NO 2 /LiBH 4 directly furnished the title dihydroisocoumarin 1a in 80% ee (82% yield). Partial as well as complete demethylation of the latter provided the dihydroisocoumarins 1b and 1c , respectively. Diastereotopy of the CH 2 H‐atoms on either side of the stereogenic center (C(3)) and the mass‐fragmentation pattern of the dihydroisocoumarins have also been described. All of the compounds synthesized were examined in vitro for antifungal activity.
Three new species of Begonia (section Baryandra, Begoniaceae) from Samar Island, the Philippines (2021)

The geographic location, climatic, and soil conditions of Samar Island render a mosaic of varied habitats which harbor numerous endemic, rare, and endangered species of plants. The island province is one of the centers of plant endemism in the Philippines. Included in this rich biodiversity of flora are members of genus Begonia of the family Begoniaceae. In 2018, researchers of the University of the Philippines found in the island three unknown Begonia species. With rhizomatous habits, persistent stipules, protandrous inflorescences, four-tepaled flowers, three winged capsules and bifid placenta, the three species are clearly members of Begonia section Baryandra. Studies of literature, herbarium specimens, and living plants support the recognition of the three new species: Begonia sohoton, Begonia tarangban and Begonia burabod.
Author Correction: Computer keyboard interaction as an indicator of early Parkinson’s disease (2018)

A correction has been published and is appended to both the HTML and PDF versions of this paper. The error has not been fixed in the paper.
Morphodynamic regime and long‐term evolution of meandering rivers (2009)

In the present contribution we focus our attention on the long‐term behavior of meandering rivers, a very common pattern in nature. This class of dynamical systems is driven by the coexistence of various intrinsically nonlinear mechanisms which determine the possible occurrence of two different morphodynamic regimes: the subresonant and the superresonant regimes. Investigating the full range of morphodynamic conditions, we objectively compare the morphologic characteristics exhibited by synthetically generated and observed planimetric patterns. The analysis is carried out examining, through principal component analysis, a suitable set of morphological variables. We show that even in the presence of the strong filtering action exerted by cutoff processes, a closer, although not yet complete, similarity with natural meandering planforms can be achieved only by adopting a flow field model which accounts for the full range of morphodynamic regimes. We also introduce a new morphodynamic length scale, m , associated with spatially oscillating disturbances. Once normalized with this length scale, the relevant morphologic features of the simulated long‐term patterns (e.g., the probability density function of local curvature and the geometric characteristics of oxbow lakes) tend to collapse on two distinct behaviors, depending on the dominant morphologic regime.
Prelithiation of Silicon–Carbon Nanotube Anodes for Lithium Ion Batteries by Stabilized Lithium Metal Powder (SLMP) (2013)

Stabilized lithium metal powder (SLMP) has been applied during battery assembly to effectively prelithiate high capacity (1500-2500 mAh/g) silicon-carbon nanotube (Si-CNT) anodes, eliminating the 20-40% first cycle irreversible capacity loss. Pressure-activation of SLMP is shown to enhance prelithiation and enable capacity matching between Si-CNT anodes and lithium nickel cobalt aluminum oxide (NCA) cathodes in full batteries with minimal added mass. The prelithiation approach enables high energy density NCA/Si-CNT batteries achieving >1000 cycles at 20% depth-of-discharge.
Fermi-surface of underdoped LaFeAsO1-xFx as determined by the Haas-van Alphen-effect (2010)

Here, we present a de Haas-van Alphen (dHvA) effect1 study on the newly discovered LaFeAsO1-xFx compounds2,3 in order to unveil the topography of the Fermi surface associated with their antiferromagnetic and superconducting phases, which is essential for understanding their magnetism, pairing symmetry and superconducting mechanism. Calculations 4 and surface-sensitive measurements 5,6,7 provided early guidance, but lead to contradictory results, generating a need for a direct experimental probe of their bulk Fermi surface. In antiferromagnetic LaFeAsO1-xFx 8,9 we observe a complex pattern in the Fourier spectrum of the oscillatory component superimposed onto the magnetic torque signal revealing a reconstructed Fermi surface, whose geometry is not fully described by band structure calculations. Surprisingly, several of the same frequencies, or Fermi surface cross-sectional areas, are also observed in superconducting LaFeAsO1-xFx (with a superconducting transition temperature Tc ~ 15 K). Although one could attribute this to inhomogeneous F doping, the corresponding effective masses are largely enhanced with respect to those of the antiferromagnetic compound. Instead, this implies the microscopic coexistence of superconductivity and antiferromagnetism on the same Fermi surface in the underdoped region of the phase diagram of the LaFeAsO1-xFx series. Thus, the dHvA-effect reveals a more complex Fermi surface topography than that predicted by band structure calculations4 upon which the currently proposed superconducting pairing scenarios10,11,12,13 are based, which could be at the origin of their higher Tcs when compared to their phosphide analogs.