gebhart/patrepeval huggingface dataset:
The concept of attached processing and attached resource computer systems (Paper Session) (1978)

Attached Processing, a new concept in business data processing, specifies a new system architecture constituting an on-line computer system of arbitrary size, made up of an arbitrary number of functionally dispersed processors which nevertheless maintain common data bases. Information stored in such a system is immediately accessible, under user-configured security controls, by any processor attached to it. Such a system can expand by simple accretion, without economic penalty. To obtain more processing throughput, one attaches more processors. To obtain more data storage, one attaches additional disk drives as needed. In its practical realization, Attached Processing assumes the form of an Attached Resource Computer. The Attached Resource Computer does not employ a central, controlling host computer. System control is decentralized. Failure of any individual processor in the system cannot bring all processing to a halt. Functional reconfigurations are easy since no processor is hard-wired to a specific task or tasks.
Development of a Viscoelastic Property Database for EOR Polymers (2010)

Abstract Partially hydrolyzed polyacrylamide (HPAM) and related polymers are widely used as mobility control agents in all chemical EOR applications, and an accurate characterization of their apparent viscosity in the reservoir rock is crucial for design and performance evaluation of these processes. Their apparent viscosity in porous media generally decreases as flow velocity increases; however, beyond a certain critical velocity, the apparent viscosity sharply increases, showing shear-thickening behavior. A procedure to predict both the shear-thinning and shear-thickening apparent viscosities, from the rheometer-measured shear and oscillatory viscosities, has been developed earlier and validated with corefloods (Delshad et al., 2008). In addition to the shear viscosity database developed earlier (Lee et al., 2009), a database of the oscillatory viscosities of the EOR polymers was therefore developed for wide ranges of polymer concentration, NaCl salinity and calcium content, and temperature. The generalized Maxwell model (GMM) is employed to estimate the relaxation time of the polymer solution, by making non-linear fitting of the measured G' and G" data to GMM. Empirical correlations were developed to predict the relaxation time, which is subsequently used to quantify the shear-thickening portion of the apparent polymer viscosity under different process conditions. The apparent viscosity estimated matches reasonably with the available coreflood data.
Achieving high brightness of silicon nanocrystal light-emitting device with a field-effect approach (2014)

We report a field-effect approach to enhance the electroluminescence (EL) from a model Si nanocrystal light-emitting device (Si-NC LED). The field effects are established within the carrier injection regions of the LEDs via introducing an i-type Si layer on the top of active layer and an Al2O3 layer between the active layer and the Si substrate. The fields are consistent in polarity with the forwardly biased electric field within the LEDs. One order of magnitude increases in the EL intensity from Si-NC LED are readily achieved after introducing the field effects.
Fluorescence background subtraction technique for hybrid fluorescence molecular tomography/x-ray computed tomography imaging of a mouse model of early stage lung cancer (2013)

The ability to visualize early stage lung cancer is important in the study of biomarkers and targeting agents that could lead to earlier diagnosis. The recent development of hybrid free-space 360-deg fluorescence molecular tomography (FMT) and x-ray computed tomography (XCT) imaging yields a superior optical imaging modality for three-dimensional small animal fluorescence imaging over stand-alone optical systems. Imaging accuracy was improved by using XCT information in the fluorescence reconstruction method. Despite this progress, the detection sensitivity of targeted fluorescence agents remains limited by nonspecific background accumulation of the fluorochrome employed, which complicates early detection of murine cancers. Therefore we examine whether x-ray CT information and bulk fluorescence detection can be combined to increase detection sensitivity. Correspondingly, we research the performance of a data-driven fluorescence background estimator employed for subtraction of background fluorescence from acquisition data. Using mice containing known fluorochromes ex vivo, we demonstrate the reduction of background signals from reconstructed images and sensitivity improvements. Finally, by applying the method to in vivo data from K-ras transgenic mice developing lung cancer, we find small tumors at an early stage compared with reconstructions performed using raw data. We conclude with the benefits of employing fluorescence subtraction in hybrid FMT-XCT for early detection studies.
Superconducting pairing of holes in the antiferromagnetic state of the two-dimensional Hubbard model (1989)

The weak-coupling form of the effective interaction between two holes in the antiferromagnetic state of the two-dimensional Hubbard model near half-filling is derived. It is shown to predict a Cooper instability in the singlet $d$-wave channel, with binding temperature ${T}_{c}&gt;100$ K. Our results differ from those of the "spin-bag" theory of Schrieffer, Wen, and Zhang.
Signal-mediated nuclear export pathways of proteins and RNAs (1996)

Although it has been known for several years that most nuclear-encoded RNAs and some patients can be exported from the nucleus to the cytoplasm, the molecular mechanisms of these transport processes have been poorly understood. Recently, signals that can induce the rapid and active nuclear export of macromolecules have been identified in the HIV-1 Rev protein, the inhibitor of cAMP-dependent protein kinase (PKI) and the hnRNP A1 protein. Thus, nuclear export appears to be mechanistically similar to nuclear import that it requires specific signal-receptor systems.
Impact of a Novel Multiparameter Decision Support System on Intraoperative Processes of Care and Postoperative Outcomes (2018)

The use of an intraoperative decision support system was associated with improved process measures, but not postoperative clinical outcomes.
Data from Imaging Biomarkers Predict Response to Anti-HER2 (ErbB2) Therapy in Preclinical Models of Breast Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; To evaluate noninvasive imaging methods as predictive biomarkers of response to trastuzumab in mouse models of HER2-overexpressing breast cancer. The correlation between tumor regression and molecular imaging of apoptosis, glucose metabolism, and cellular proliferation was evaluated longitudinally in responding and nonresponding tumor-bearing cohorts.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Mammary tumors from MMTV/HER2 transgenic female mice were transplanted into syngeneic female mice. BT474 human breast carcinoma cell line xenografts were grown in athymic nude mice. Tumor cell apoptosis (NIR700-Annexin V accumulation), glucose metabolism [2-deoxy-2-[&lt;sup&gt;18&lt;/sup&gt;F]fluoro-d-glucose positron emission tomography ([&lt;sup&gt;18&lt;/sup&gt;F]FDG-PET)], and proliferation [3′-[&lt;sup&gt;18&lt;/sup&gt;F]fluoro-3′-deoxythymidine-PET ([&lt;sup&gt;18&lt;/sup&gt;F]FLT-PET)] were evaluated throughout a biweekly trastuzumab regimen. Imaging metrics were validated by direct measurement of tumor size and immunohistochemical analysis of cleaved caspase-3, phosphorylated AKT, and Ki67.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; NIR700-Annexin V accumulated significantly in trastuzumab-treated MMTV/HER2 and BT474 tumors that ultimately regressed but not in nonresponding or vehicle-treated tumors. Uptake of [&lt;sup&gt;18&lt;/sup&gt;F]FDG was not affected by trastuzumab treatment in MMTV/HER2 or BT474 tumors. [&lt;sup&gt;18&lt;/sup&gt;F]FLT-PET imaging predicted trastuzumab response in BT474 tumors but not in MMTV/HER2 tumors, which exhibited modest uptake of [&lt;sup&gt;18&lt;/sup&gt;F]FLT. Close agreement was observed between imaging metrics and immunohistochemical analysis.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Molecular imaging of apoptosis accurately predicts trastuzumab-induced regression of HER2&lt;sup&gt;+&lt;/sup&gt; tumors and may warrant clinical exploration to predict early response to neoadjuvant trastuzumab. Trastuzumab does not seem to alter glucose metabolism substantially enough to afford [&lt;sup&gt;18&lt;/sup&gt;F]FDG-PET significant predictive value in this setting. Although promising in one preclinical model, further studies are required to determine the overall value of [&lt;sup&gt;18&lt;/sup&gt;F]FLT-PET as a biomarker of response to trastuzumab in HER2&lt;sup&gt;+&lt;/sup&gt; breast cancer.&lt;/p&gt;&lt;/div&gt;
Links Between Self-Control, Cannabis Use and Methods of Consumption in University Students Who Use Alcohol: A 14-week Longitudinal Study (2023)

The current study used a semester-long EMA design to test for differences in self-control (measured by a stop-signal task and perceived self-control demands) in undergraduate students on days they do and do not use cannabis, as well as adjusting for students own typical levels of cannabis use. Differences in self-control were further assessed across methods of consumption (e.g., inhalation vs. ingestion vs. concentrates) on days when students used cannabis. Data from n=196 undergraduates (Mage=20.6; 63.3% female) across 14 weekends in 2021 was examined using Multilevel Modelling to accommodate repeated measures nested within individuals. In this longitudinal design using objective and subjective measures, findings revealed no meaningful differences in self-control among students who did and did not use cannabis, and across the various methods of consumption. Effects were within the smallest effect size of interest limits and results provide reassurance that recreational or occasional cannabis use likely isn’t related to self-control.
Helicobacter pylori Infection Up‐regulates Gland Mucous Cell‐Type Mucins in Gastric Pyloric Mucosa (2003)

In addition to the synthesis of GMC mucins increasing reversibly, their metabolism or release may also increase reversibly in H. pylori-associated gastritis. The up-regulation of the expression of gastric GMC mucins may be involved in defense against H. pylori infection in the gastric surface mucous gel layer and on the gastric mucosa.
Manufacturing lines under surplus-based control: multiple products and bounded buffers (2015)

Challenged by the scheduling complexity for production flow processes in industrial facilities, we study the performance of multi-product producing lines. We analyse the performance of multi-product lines that consist a number of machines and bounded buffers with preselected base stock levels. It is assumed that each manufacturing machine in the line is capable of working with several product types, but only operate on one product at a time. The network is operated under a surplus-based production control policy in the presence of perturbations and production demand fluctuations. We derive bounds on the demand tracking accuracy for each product type, regardless its flow direction in the multi-product line. In addition, for a multi-product line with unidirectional product flow, we obtain a quantitative relation between demand tracking accuracy, its inventory levels, numbers of product types, buffer capacity limits and perturbations. The accuracy of the obtained demand tracking bounds is illustrated by numerical simulations. By means of simulation experiments, we show that the obtained results have a valuable meaning and can be used as a reference tool in practice.
Digital controller for interleaved PFC operating in critical mode – Emerson Network Power HK Ltd (2013)

Won the Second Runner-Up in the 2012–13 Best Final Year Project Competition (Individual) organised by the Energy Institute (Hong Kong Branch).
ChemInform Abstract: Synthese von Aziminen aus Azomethiniminen durch Dipol‐metathese. (1983)

Abstract Die Umsetzung von Azomethiniminen (I) mit den Nitrosoverbindungen (II) ergibt unter Eliminierung von Trifluoraceton die Azimine (III).
Static Magnetic Fields for Treatment of Fibromyalgia: A Randomized Controlled Trial (2001)

Although the functional pad groups showed improvements in functional status, pain intensity level, tender point count, and tender point intensity after 6 months of treatment, with the exception of pain intensity level these improvements did not differ significantly from changes in the Sham group or in the Usual Care group.
[Prognostic factors of epithelial ovarian cancer in young women]. (2003)

Epithelial ovarian carcinoma in patients with age </= 40 has higher incidence of early stage, well differentiation and mucous cystadenocarcinoma as well as a higher 5-year survival rate but lower possibility of residual tumor and ascites. Stage, residual tumor size and age are independent prognostic factors of epithelial ovarian carcinoma.
Characterization of the apoptotic and therapeutic activities of the histone deacetylase inhibitors LAQ824 and LBH589 using a mouse model of B cell lymphoma. (2007)

Histone deacetylase inhibitors (HDACi) can elicit a range of biological responses that affect tumor growth and survival including inhibition of tumor cell cycle progression, induction of tumor cell-selective apoptosis, suppression of angiogenesis and modulation of immune responses and show promising activity against hematological malignancies in clinical trials. Using the Eµ-myc model of B-cell lymphoma and the HDACi LBH589 and LAQ824 we demonstrated a direct correlation between induction of tumor cell death in vivo and therapeutic efficacy. Neither HDACi required p53 activity or a functional death receptor pathway, but mediated lymphoma cell death via the intrinsic apoptotic pathway as demonstrated by decreased apoptosis and therapeutic activity of LBH589 and LAQ825 against Eµ-myc/Bcl-2 and Eµ-myc/Bcl-XL cells. Interestingly, both LBH589 and LAQ824 effectively killed Eµ-myc/caspase-9-/- and Eµ-myc/Apaf-1-/- lymphomas, which lack a functional apoptosome and thus have a defective apoptotic program downstream of the mitochondria. These cells did not display classic morphological or biological features of apoptosis following treatment with LBH589 and LAQ824 however their clonogenic capacity was significantly reduced and interestingly electron microscopy analysis indicated that these HDACi-treated cells underwent autophagy. Importantly, both Eµ-myc/caspase-9-/- and Eµ-myc/Apaf-1-/- responded to LBH589 and LAQ824 in vivo indicating that in the absence of an effective apoptotic program downstream of mitochondrial membrane perturbation, tumor cells can undergo autophagy and this is sufficient to mediate therapeutic efficacy. Our studies provide important information regarding the mechanisms of action of LBH589 and LAQ824 that may have broader implications regarding future stratification of patients receiving therapy with these agents and the use of these compounds in combination with other anti-cancer agents.
Do Introns Favor or Avoid Regions of Amino Acid Conservation? (2002)

Are intron positions correlated with regions of high amino acid conservation? For a set of ancient conserved proteins, with intronless prokaryotic but intron-containing eukaryotic homologs, multiple sequence alignments identified residues invariant throughout evolution. Intron positions between codons show no preferences. However, introns lying after the first base of a codon prefer conserved regions, markedly in glycines. Because glycines are in excess in conserved regions, this behavior could reflect phase-one introns entering glycine residues randomly in the ancestral sequences. Examination of intron positions within codons of evolutionarily invariable amino acids showed that roughly 50% of these introns are bordered by guanines at both 5'- and 3'-ends, 25% have a G only before the intron, and 5% have a G only after the intron, whereas about 20% are bordered by nonguanine bases.
Axial Impulse Turbine Design for Supercritical CO₂ Cycle (2018)

본 논문에서는 초임계 이산화탄소(sCO₂) 발전 사이클에 적용되는 축류 터빈 개발에 대하여 다루고 있다. 초임계 이산화탄소 발전사이클의 경우 초임계 상태로 작동 유체가 유지됨으로써 높은 밀도와 낮은 비체적으로 인하여 기존의 스팀 랭킨 사이클에 비하여 터빈 크기를 1/20 이하로 소형화가 가능하다. 그러나 이러한 장점은 터보 머시너리 개발에는 상당한 난점으로 작용한다. 이산화탄소의 임계점 부근 및 고온/고압 조건에서의 운전되는 터빈의 경우 낮은 비체적으로 인한 높은 회전수와 고압 조건으로 인한 높은 축력이 개발상의 난점이 된다. 이의 해결을 위하여 본 연구에서는 부분유입 운전 방식으로 운전되는 충동형 축류 터빈을 개발하였다. 부분유입 충동형 터빈 개념을 적용하여 입구 조건 135bar, 392℃, 출구 조건 77bar, 질량 유량 1.74kg/s의 설계조건에서 지름 73mm, 날개 높이 8mm, 정격 회전수 45,000RPM의 터빈을 설계할 수 있었으며, 기계적인 안정성을 위하여 틸팅패드 베어링을 적용한 터빈 시스템을 개발하였다. 개발된 터빈은 최대 입구 조건 100 bar, 205 ℃에서 45분의 연속 운전을 수행하였다.
Regulation of endometrial prostaglandins during the menstrual cycle and in early pregnancy (1990)

Prostaglandins are important regulators of endometrial function. In turn, their secretion is controlled by endocrine and paracrine mediators. Cyclical effects of ovarian oestrogen and progesterone throughout the menstrual or oestrous cycle result in overall higher levels of prostaglandin release during the secretory or luteal phase of the cycle than during the proliferative phase. Potential paracrine regulators of endometrial origin include cytokines, growth factors and histamine, some of which may arise from infiltrating cells. Embryo-derived factors can regulate endometrial prostaglandin release in early pregnancy. Both platelet-activating factor and ovine trophoblast protein-1 (an embryonic interferon) modify prostaglandin release from primary cultures of endometrial cells of human and ovine origin respectively. Manipulation of such mediators may provide new means for fertility control.
Cell Fusion in Skeletal Muscle: Central Role of NFATC2 in Regulating Muscle Cell Size (2003)

Skeletal muscle formation and growth require the fusion of myoblasts to form multinucleated myofibers or myotubes. Studies of the calcium activated transcription factor NFATC2 demonstrate that cell fusion during myogenesis occurs in two distinctly regulated phases. NFATC2 controls myoblast fusion after the initial formation of a myotube and is necessary for further cell growth. Recently we have shown that following myotube formation, myotubes recruit myoblast fusion by secretion of IL-4 and prostaglandin F2alpha. Molecules that control muscle cell fusion are of great interest from a therapeutic standpoint to enhance growth of muscle after injury or to alleviate the loss of muscle mass found in disease or aging.
Entomopathogenic Nematodes as Control Agents of Developmental Stages of the Black-Legged Tick, Ixodes scapularis (1998)

Thirteen species or strains of entomopathogenic nematodes of the genera Steinernema and Heterorhabditis were tested in vitro against unfed and engorged larvae, nymphs, and adults of the black-legged tick, Ixodes scapularis. Nematodes were pathogenic to engorged female ticks, but not to unfed or engorged larvae, nymphs, males, and unfed females. Steinernema riobravis (355) and Heterorhabditis megidis (M145) killed ticks most rapidly, with mean day of death postinfection of 2.5 and 3.5 days, respectively. However, all nematode strains and species were lethal to engorged female ticks within 7.5 days. Development of juveniles and reproduction of nematodes did not occur inside the tick cadavers, because no infective juveniles (IJs) emerged from cadavers after 40 days, and no nematode life-cycle stages other than the primary IJs could be isolated from cadavers. Egg masses were produced by 4 of 702 nematode-infected, engorged females. Egg masses produced were not significantly smaller than masses produced by control ticks; however, only 1 of the 4 egg masses hatched, whereas all of the egg masses produced by the control ticks hatched. Entomopathogenic nematodes may be useful as an alternative management method for I. scapularis populations, and may be more acceptable than acaricidal chemicals for use in infested areas.
Moana (2017)

We used two different solutions for generating crashing waves for more than 40 shots in Moana. Our profile curve based wave deformer was developed and used for art-directed design of shapes, motion, and composition of running and crashing waves. In contrast to previously developed wave deformers, we designed a cross section shape animation by providing a series of profile curves which represented the animation keys. These profile curves could be hand plotted curves or mathematically calculated changing profiles, which means any kind of choreographic touch could be applied for designing the wave shapes. We could design multiple crashing waves for huge scale tsunami scenes and we could art direct the timing and composition of the waves which would fit well with the character animation and camera works.
Mesostructure Design with Gemini Surfactants: Supercage Formation in a Three-Dimensional Hexagonal Array (1995)

At low temperatures, liquid crystal-like arrays made up of inorganic-cluster and organic molecular units readily undergo reversible lyotropic transformations. Gemini surfactants, with two quaternary ammonium head groups separated by a methylene chain of variable length and with each head group attached to a hydrophobic tail, can be used to control organic charge sitting relative to the bivariable hydrophobic tail configurations. This approach has led to the synthesis of a mesophase (SBA-2) that has three-dimensional hexagonal (P6(3)/mmc) symmetry, regular supercages that can be dimensionally tailored, and a large inner surface area. This mesostructure analog of a zeolite cage structure does not appear to have a lyotropic surfactant or lipid liquid crystal mesophase counterpart. Through the modification of gemini charge separation and each of the two organic tails, these syntheses can be used to optimize templating effects, including the synthesis of MCM-48 at room temperature.
Peptoid-based reprogrammable template for cell-permeable inhibitors of protein–protein interactions (2021)

The development of inhibitors of intracellular protein-protein interactions (PPIs) is of great significance for drug discovery, but the generation of a cell-permeable molecule with high affinity to protein is challenging. Oligo(<i>N</i>-substituted glycines) (oligo-NSGs), referred to as peptoids, are attractive as potential intracellular PPI inhibitors owing to their high membrane permeability. However, their intrinsically flexible backbones make the rational design of inhibitors difficult. Here, we propose a peptoid-based rational approach to develop cell-permeable PPI inhibitors using oligo(<i>N</i>-substituted alanines) (oligo-NSAs). The rigid structures of oligo-NSAs enable independent optimization of each <i>N</i>-substituent to improve binding affinity and membrane permeability, while preserving the backbone shape. A molecule with optimized <i>N</i>-substituents inhibited a target PPI in cells, which demonstrated the utility of oligo-NSA as a reprogrammable template to develop intracellular PPI inhibitors.