gebhart/patrepeval huggingface dataset:
Anti-PD1 plus BRAF/MEK inhibitors (triplet therapy) after failure of standard therapy in patients (pts) with advanced melanoma. (2023)

9528 Background: Preclinical models support the combination of immune checkpoint inhibitors (ICI) with targeted therapy (TT), suggesting a synergistic effect; however, clinical trials evaluating the efficacy of triplet combination in first-line setting showed limited advantage compared to TT only. Early data from the phase II TRIDeNT (NCT02910700) study showed promising clinical activity in anti-PD1 refractory pts. We sought to evaluate the efficacy of combined TT plus anti-PD1 after the failure of standard therapy in pts with advanced melanoma. Methods: This retrospective, multicenter study included pts with advanced melanoma who were treated with a BRAF inhibitor and a MEK inhibitor in combination with a PD1 inhibitor after failure of a minimum of one standard therapy in seven major melanoma centers between February 2016 and July 2022. Demographics, disease characteristics, therapy details, and outcome data were evaluated. Results: 59 pts were identified; med age was 48 yrs (range, 24-80), 32 pts (54.2%) were males, 20 pts (33.9%) had ECOG PS 1, 46 pts (78%) had 3 or more metastatic sites, 40 pts (67.8%) had brain metastases, and 25 (42.2%) had LDH levels above the upper limit of normal before initiation of triple therapy. Median follow-up time was 16.2 months (IQR, 6.02-20.81). Median number of previous treatment lines was 2 (range, 1-6); 40 pts (67.8%) were pretreated with at least one line of ICI and TT in any sequence. Of 55 pts who received ICI (n = 41 CTLA4 plus PD1; n = 9 PD1 mono; n = 2 CTLA4 mono; n = 3 PD1-based therapy) prior to triplet therapy, 44 pts (80%) were primary resistant (progressive disease (PD); stable disease (SD) for &lt; 6 months), and 11 pts (20%) secondary resistant (complete response (CR), partial response (PR), SD for &gt; 6 months) to the ICI therapy. Treatment with triplet therapy resulted in an overall response rate (ORR) of 44.1% (n = 26) and a disease control rate (DCR) of 55.9% (n = 33) with a median duration of response of 13.7 months (range, 5.4-33.2). Median PFS for the entire cohort was 6 months (95% CI, 3.88-8.08), with a 12-month PFS of 29.4% (95% CI, 17.8-42.1) and a 24-month PFS of 20.2% (95% CI, 11.0-32.8). Median OS was 15.7 months (95% CI, 8.1-23.3 months), with a 12-month OS of 52.7% (95% CI, 39.1-65.7) and a 24-month OS of 43.2% (95% CI, 29.6-55.9). Pts with extracerebral PD prior to triplet therapy (40.7%, n = 24) showed an ORR of 50%, pts with intracerebral PD (32.2%, n = 19) of 47.4%, and pts with global PD (27.1%, N = 16) of 31.3%. Treatment-related adverse events (TRAE) of grade ≥3 occurred in 17 of 59 pts (28.8%), of which cytokine release syndrome (n = 7) and hepatitis (n = 3) were the most common. In 16.9% (n = 10) of pts, TRAEs led to treatment discontinuation. Conclusions: Triple therapy has shown promising efficacy in heavily pretreated pts with advanced melanoma and may represent a treatment option after failure of standard therapy with ICI and TT.
Relative Platelet-derived Growth Factor Receptor Subunit Expression Determines Cell Migration to Different Dimeric Forms of PDGF (1990)

Platelet-derived growth factor (PDGF) receptor transfectants of a fibroblastoid cell line (BHK) have been used to investigate the ability of the three dimeric forms of PDGF to elicit a chemotactic response. Cells transfected with the beta receptor subunit were only responsive to PDGF-BB, whereas cells expressing the alpha-receptor subunit were equally responsive to all three dimeric forms, PDGF-AA, PDGF-AB, and PDGF-BB. A positive chemotactic response correlated with rearrangement of actin organization. In a study of human arterial smooth muscle cells that express both PDGF receptor subunits endogenously, we again found that recombinant PDGF-AA could elicit a chemotactic response. However, the two smooth muscle cell isolates we examined differed in their chemotactic response to PDGF-AA. This difference correlated closely with their ability to respond mitogenically to this PDGF dimeric form, and the magnitude of both chemotactic and mitogenic responses was related to the proportion of the two receptor subunit species at the cell surface.
A green tea-containing starch confection increases plasma catechins without protecting against postprandial impairments in vascular function in normoglycemic adults (2016)

Postprandial hyperglycemia (PPH) increases cardiovascular disease risk regardless of glucose intolerance by transiently impairing vascular endothelial function (VEF) by limiting nitric oxide bioavailability in an oxidative stress-dependent manner. Preclinical studies show that green tea catechins attenuate PPH by inhibiting starch digestion. We hypothesized that a starch-based confection containing catechin-rich green tea extract (GTE) would limit PPH-mediated impairments in VEF in normoglycemic adults. We formulated a unique GTE confection and then conducted a double-blind, randomized, controlled, crossover study in healthy men (n = 15; 25.3 ± 1.0 years; 22.4 ± 1.8 kg m(-2)) in which they ingested starch confections (50 g carbohydrate) formulated with or without GTE (1 g) prior to evaluating sensory characteristics of confections and plasma glucose, biomarkers of lipid peroxidation and nitric oxide homeostasis, and brachial artery flow-mediated dilation (FMD) at 30 min intervals for 3 h. Sensory evaluation of confections indicated acceptable consumer appeal and an inability to distinguish between confections regardless of GTE. Plasma catechins concentrations increased following ingestion of the GTE confection. However, plasma glucose peaked at 60 min (P < 0.05) following confection ingestion and was unaffected throughout the postprandial period by the GTE confection (P > 0.05). FMD was significantly decreased only at 60 min regardless of confections containing GTE. Also at 60 min, both confections similarly increased plasma malondialdehyde while decreasing arginine and increasing asymmetric dimethylarginine/arginine. The successfully formulated GTE-containing confection effectively delivered catechins, but without mitigating PPH-mediated impairments in VEF in association with oxidative stress that likely limits nitric oxide bioavailability.
Comparative patterns of follicle development and selection in ruminants. (1999)

Expanding technological capabilities, particularly in ultrasonography and molecular endocrinology, have bridged the gap between form and function of the ovary, and have been a catalyst for intense research activity in this area during the last decade. However, the study of follicular dynamics is still in its infancy in ruminant species other than cattle, and controversy persists regarding the pattern of follicular growth and the existence of follicular dominance. The bovine model of ovarian function is presented as a foundation for concepts surrounding the control of follicular development in ruminants, and to place in context the results of recent studies in sheep, goats, muskoxen, cervids and camelids. This comparative approach is used to determine important generalities that appear to be applicable, as fundamental physiological phenomena, to all ruminant species. Although clear differences in follicular dynamics are evident, differences appear to be specific rather than general, and the following conclusions are consistent with results reported in ruminant species to date: (1) follicles grow in a wave-like fashion; (2) periodic surges in circulating FSH are associated with follicular wave emergence; (3) selection of a dominant follicle involves a decline in FSH and acquisition of LH responsiveness; (4) periodic anovulatory follicular waves continue to emerge until occurrence of an LH surge (that is, at the time of luteolysis during the ovulatory season or during transition from the anovulatory season); (5) within species, there is a positive relationship between the duration of the oestrous cycle and the number of follicular waves; (6) progesterone suppresses LH secretion and growth of the dominant follicle; (7) the duration of the interwave interval is a function of follicular dominance, and is negatively correlated with circulating FSH; (8) follicular dominance in all species is more pronounced during the first and last follicular waves of the oestrous cycle; and (9) pregnancy, the prepubertal period and seasonal anoestrus are characterized by regular, periodic surges in FSH and emergence of anovulatory follicular waves.
An immunological method for granulovirus detection in larvae ofTuta absoluta: searching for isolates with prospects for biological control of this pest in Colombia (2014)

The tomato leafminer Tuta absoluta is an important insect pest of tomato crops worldwide. Biological control using entomopathogenic viruses such as isolates of Phthorimaea operculella granulovirus (PhopGV) can be a promising tool for suitably controlling this pest. However to date, few viral isolates from T. absoluta have been reported. Therefore, the aim of this study was to develop an economic, fast and accurate immunological technique for granulovirus detection and to evaluate viral presence in T. absoluta larvae from field samples collected in Colombia. Polyclonal antibodies against PhopGV were produced by using hens and rabbits. The production system in hen was selected as the most efficient and simple method. Then, a dot-blot test was developed, demonstrating the ability of antibodies to recognize granulovirus. Finally, granulovirus presence in 1186 T. absoluta larvae collected in the most important tomato production areas in Colombia was evaluated, and eight isolates were found in Boyacá and Cundinamarca (0.7% of occurrence). These results constitute the first report of a granulovirus isolated from T. absoluta larvae which had been naturally infected in Colombia's tomato producing-fields, and thereby validates the use of the immunological technique to detect granulovirus in field conditions.
THE PREVENTION AND MANAGEMENT OF POST‐MENOPAUSAL OSTEOPOROSIS (1977)

In 6 groups of peri- and post-menopausal women, there was an inverse relation between the urinary sediment smear maturation value and the fasting urinary hydroxyproline/creatinine ratio. Administration of ethinyloestradiol and Progynova both reduced urinary hydroxyproline into the pre-menopausal range, the fall being proportional to the starting value. Oestrogen therapy also produced a significant fall in plasma ionised calcium. In a prospective trial, oestrogen therapy prevented post-menopausal bone loss but calcium therapy was less effective. It is suggested that a high fasting urinary hydroxyproline/creatinine ratio might be taken as an indication for oestrogen therapy in post-menopausal women. In established post-menopausal osteoporosis, pre-disposing risk factors appear to be low calcium intake, malabsorption of calcium and low oestrogen status. These patients appear to represent the fast bone-losers in the post-menopausal population. The accelerated bone loss can be wholly or partially corrected by hormone replacement therapy and by calcium supplements given to those with normal absorption only. These therapies also prevent loss of height due to further crush fractures. The malabsorption of calcium is very resistant to vitamin D therapy but responds to 1alpha-OHD3. Balance data suggest that the most effective therapy may be a combination of 1alpha-OHD3 with oestrogen.
Pain Sensitivity and Autonomic Factors Associated With Development of TMD: The OPPERA Prospective Cohort Study (2020)

Multiple studies report that individuals with chronic temporomandibular disorder (TMD) have enhanced sensitivity to experimental pain. Additionally, chronic TMD cases show altered autonomic function, including elevated heart rate and reduced heart rate variability. However, causal inferences regarding the association between TMD and pain sensitivity and autonomic function cannot be drawn from these cross-sectional observations. The prospective OPPERA study examines whether measures of pain sensitivity or cardiac autonomic function provide predictive value in TMD incidence. A cohort of 2,737 initially TMD-free people was followed for up to 5.2 years, during which time 260 developed first-onset TMD. Fourteen of 39 experimental pain measures produced significant hazard ratios, such that greater pain sensitivity was associated with greater TMD incidence. A single autonomic measure – heart rate at rest – was also associated significantly with greater TMD incidence. In contrast, using the same measures of pain sensitivity and cardiac autonomic function, we previously reported a larger group of variables that was significantly associated with chronic TMD in the OPPERA case-control study. Future studies should investigate whether premorbid pain sensitivity or autonomic function more specifically predicts risk of developing chronic TMD than first-onset TMD.
Pattern discovery via entropy minimization (1999)

We propose a framework for learning hidden-variable models by optimizing entropies, in which entropy minimization, posterior maximization, and free energy minimization are all equivalent. Solutions for the maximum a posteriori (MAP) estimator yield powerful learning algorithms that combine all the charms of expectation-maximization and deterministic annealing. Contained as special cases are the methods of maximum entropy, maximum likelihood, and a new method, maximum structure. We focus on the maximum structure case, in which entropy minimization maximizes the amount of evidence supporting each parameter while minimizing uncertainty in the sufficient statistics and cross-entropy between the model and the data. In iterative estimation, the MAP estimator gradually extinguishes excess parameters, sculpting a model structure that reflects hidden structures in the data. These models are highly resistant to over-fitting and have the particular virtue of being easy to interpret, often yieldin...
Medium voltage multilevel AC regenerative load with One-Cycle Control (2011)

Variable linear or nonlinear loads are necessary for testing medium voltage (MV) high power AC power supplies. Generally, those AC power supplies require performance validation, burn-in, and/or life-time testing under different load conditions, defined by the end-user or standards for the given applications. For this purpose, this paper presents a multilevel converter-based AC regenerative electronic load with One-Cycle Control (OCC), which is based on a five-level diode-clamped multilevel converter and can emulate any impedance load, whether linear or nonlinear, steady or dynamic. Simulation and experimental results are presented to verify the performance of the proposed multilevel AC regenerative load.
Side mode suppression ratio for 1.3-μm loss-coupled DFB lasers with large loss-coupling coefficient (1996)

Injection current dependence of side mode suppression ratio of HR-AR facet coated, loss coupled DFB lasers is examined through numerical simulation and experiments.
Occult Invasive Lobular Carcinoma of Breast Detected by Stomach Metastasis: A Case Report (2012)

Gastric metastasis or carcinomatosis from primary breast cancer is a rare phenomenon. It is more prevalent in the invasive lobular type of breast cancer, although the most common histologic subtype of breast cancer is the invasive ductal type (1-4). To date, there are only a few case reports demonstrating that gastric metastases were manifested as an initial presentation of invasive lobular breast cancer (5-9). Nevertheless, most of the cases were distant recurrences occurring in patients with breast cancer histories (5-8). As of now, there is only one published case study reporting about gastric metastasis originating from occult breast lobular cancer and its focus was mainly on the distinct immunohistochemical features between primary gastric cancer and metastatic breast cancer (9). Therefore, in our report of a case of invasive lobular breast cancer identified by gastric metastasis, its imaging features, which significantly contributed to the detection of occult breast cancer, were described. CASE REPORT
Solutions to hidden terminal problems in wireless networks (1997)

The floor acquisition multiple access (FAMA) discipline is analyzed in networks with hidden terminals. According to FAMA, control of the channel (the floor) is assigned to at most one station in the network at any given time, and this station is guaranteed to be able to transmit one or more data packets to different destinations with no collisions. The FAMA protocols described consist of non-persistent carrier or packet sensing, plus a collision-avoidance dialogue between a source and the intended receiver of a packet. Sufficient conditions under which these protocols provide correct floor acquisition are presented and verified for networks with hidden terminals; it is shown that FAMA protocols must use carrier sensing to support correct floor acquisition. The throughput of FAMA protocols is analyzed for single-channel networks with hidden terminals; it is shown that carrier-sensing FAMA protocols perform better than ALOHA and CSMA protocols in the presence of hidden terminals.
Stress-induced hyperalgesia: animal models and putative mechanisms (2006)

Stress has been shown to affect brain activity and promote long-term changes in multiple neural systems. A variety of environmental and/or stressful stimuli have been shown to produce analgesia, a phenomenon often referred to as stress-induced analgesia (SIA). However, acute and chronic stresses also produce hyperalgesia in various behavioral tests. There are now several animal models in which stress enhances nociceptive responses. The dysfunction of the hypothalamo-pituitary-adrenocortical axis (HPA axis) and multiple neurotransmitter systems in the central nervous system (CNS), including endogenous opioid, serotonergic and noradrenergic systems, has been reported. These stress-induced hyperalgesia models may contribute to a better understanding of chronic pain and provide a more rational basis for drug therapies in a variety of pain syndromes.
Antimony Oxide-Modified Vanadia-Based CatalystsPhysical Characterization and Catalytic Properties (2001)

Antimony-modified vanadia-on-titania catalysts were prepared for the selective oxidation of o-xylene to phthalic anhydride by ball milling of powder mixtures followed by calcination. A binary Sb2O3−V2O5 system was also prepared for comparison purposes. The resulting materials were physically characterized by surface area measurements, X-ray diffraction analysis (XRD), laser Raman spectroscopy, X-ray absorption fine structure (XAFS) spectroscopy, electron spin resonance (ESR), magnetic susceptibility determination, and 15V solid-state NMR. The catalytic performance of the TiO2-supported materials was tested for o-xylene oxidation. After calcination of the Sb2O3−V2O5 binary mixture at 673 K, Sb3+ is almost quantitatively oxidized to Sb5+, while both V3+ and V4+ are detected. V3+ and some V4+ are most likely located in a nonstoichiometric VSbO4-like structure, while the majority of V4+ preferentially concentrates within shear domains in oxygen-deficient V2O5-x particles. In the titania-supported catalyst system, both Sb2O3 and V2O5 spread on the anatase surface. Sb3+ is oxidized to Sb5+, and V3+, V4+, and V5+ are detected. VSbO4-like structures are not observed. The presence of antimony leads to the formation of presumably V3+−O−V5+ redox couples. The paramagnetic centersin contrast to the binary mixtureare largely isolated. Antimony preferentially migrates to the surface and appears to exhibit a dual function catalytically. It is inferred from the experimental data that the addition of antimony leads to site isolation and to a reduction of surface acidity. We suggest that V−O−V−O−V domains or clusters are interrupted by incorporation of Sb to form V−O−Sb−O−V species. As a consequence of this site isolation and a reduction of surface acidity, overoxidation of o-xylene is reduced. These two effects are therefore most probably responsible for the improved selectivity of the ternary catalyst system over the binary one toward phthalic anhydride.
Solution photolysis of cis- and trans-2-methylcyclopropyl methyl ketone (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolution photolysis of cis- and trans-2-methylcyclopropyl methyl ketoneWilliam G. Dauben, Leonard Schutte, and Richard E. WolfCite this: J. Org. Chem. 1969, 34, 6, 1849–1851Publication Date (Print):June 1, 1969Publication History Published online1 May 2002Published inissue 1 June 1969https://pubs.acs.org/doi/10.1021/jo01258a069https://doi.org/10.1021/jo01258a069research-articleACS PublicationsRequest reuse permissionsArticle Views107Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Modèle cinétique de deshydratation du sulfate de magnesium pour le stockage d’énergie thermique par composite à sorption (2017)

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A Human-Machine Interface for assistive exoskeleton based on face analysis (2008)

This paper proposes a human machine interface for assistive exoskeleton based on face analysis. The 4 DoF assistive robotic system designed is dedicated to people suffering from myopathy and aims to compensate for the loss of mobility in the upper limb. The proposed interface is able to convert user head gesture and mouth expression into a suitable control command. Moreover, we propose a visual context analysis component to make a more accurate command. The tests conducted show that the use of vision based interface is particularly adapted to disabled people. In this paper, we will first describe the problematic and the designed mechanical system. Next, we will describe the two approaches developed for visual sensing interface: head control and mouth expression control. We will focus on mouth extraction algorithm. Finally, we introduce the context detection for scene understanding.
Seeking Fellow Invisibles (2017)

This piece is a creative non-fiction piece. The monologue is centered on a question that my mentor and HDEV 100 Professor, Myra Sabir, asked the whole class in the first couple weeks of the semester. "What is your enough?" The question goes deeper than most; it causes you to really look at your life, the world around you, and who you really are. If you were to die tomorrow what is your enough? What would allow you to die with the feeling of accomplishment and happiness? "Seeking Fellow Invisibles" is about what this question made me realize, how it opened my eyes. I compare myself to others and society and what their enough would be. I dig into my past and portions of the dark times in my life. It's a painfully personal piece but the whole point is to give clarity and inspiration to those whose visions are still blurred by what others want from them. It goes beyond materialism and challenges the readers to search deeper and look inside themselves. The whole point is to understand who you really are and what you really want.