gebhart/patrepeval huggingface dataset:
Abortion due to infection with Chlamydia psittaci in a sheep farmer's wife. (1985)

A farmer's wife who had helped with lambing aborted spontaneously in March after a short febrile illness in the 28th week of her pregnancy. She developed disseminated intravascular coagulation post partum with acute renal failure and pulmonary oedema. Recovery was complete after two weeks of hospital care. A strain of Chlamydia psittaci, probably of ovine origin, was isolated from the placenta and fetus. The patient's serum showed rising titres of antibody against chlamydia group antigen; the placental and fetal isolates; and a known ovine abortion, but not a known avian, strain of C psittaci. IgG against both ovine abortion and enteric strains of C psittaci was detected, but IgM against only an abortion strain was detected. Histological examination showed pronounced intervillus placentitis with chlamydial inclusions in the trophoblast but no evidence of fetal infection or amnionitis. Laboratory evidence of chlamydial infection was found in an aborting ewe on the farm in January and in remaining sheep and lambs in July. Doctors should recognise the possible risk to pregnant women in rural areas where chlamydial infections in farm animals are widespread.
MOBiNET – an innovative approach for a European-wide ITS service platform (2014)

The paper shows an innovative approach for a European-wide ITS Service platform which addresses current barriers of cooperative system-enabled service deployment such as lack of harmonised services, availability of communication means, inaccessibility and incompatibility of transport-related data, fragmentation of end user subscriptions and payment services, and proprietary technologies in user devices. Primary goal is the holistic simplification of the overall process by bringing together mobility service offerings and demand in a common market place. In this paper we present the use cases that guided the initial platform development and the resulting architecture constitute. Particularly, we describe how the platform supports cooperative systems at the example of the green-light optimal-speed advisory use case.
[Evaluation of therapeutic strategies for myocardial infarction: the ESTIM Midi-Pyrénées survey]. (2005)

pre-hospital management allows early revascularisation. In our region there was no significant prognostic difference between pre-hospital thrombolysis and primary angioplasty. It shows that the logistic and therapeutic potentials of prehospital care are not being sufficiently exploited.
A Fast Mach Network {IPC} Implementation (1991)

This paper describes an implementation of network Mach IPC optimized for clusters of processors connected by a fast network, such as workstations connected by an Ethernet or processors in a non-shared memory multiprocessor. This work contrasts with earlier work, such as the netmsg server, which has emphasized connectivity (by using robust and widely available protocols such as TCP/IP) and configurability (with an entirely user-state implementation) at the expense of performance. The issues addressed by this work are support for low latency delivery of small and large messages, support for port capabilities and reference counting, and integration with the existing local Mach IPC implementation. Low latency for small messages requires careful buffer and control flow management; this work is compared with other fast RPC work described in the literature. Low latency for large messages, particularly for faster networks, requires an avoidance of copying, which can be achieved thro...
Time-Spectral Characteristics of Large-Scale Cloud Systems in the Tropical Pacific (1972)

Time series of areal cloud coverage over the central Pacific are studied to determine the large-scale variations of tropical disturbance activity for a four-month period in 1967. The persistent and fluctuating components are found to be more prevalent in regions of high and low mean cloudiness, respectively, with major longitudinal variations in activity most evident in the Southern Hemisphere. Normalized power spectra show that the transient activity occurring in the equatorial zone is dominated by shorter periods of about four days, while longer periods are dominant away from the equator. Coherency magnitudes and phases between different locations indicate that propagating cloud systems are most identifiable at lower frequencies in the Southern Hemisphere, and at somewhat higher frequencies in the Northern Hemisphere. Activity with periods in excess of five days consists largely of both westward and eastward propagation on the planetary wave scale. The shorter periods appear to consist of both synoptic-scale and planetary-scale modes, with westward propagation dominant near the equator.
Data from A Novel Role of Interleukin-13 Receptor α2 in Pancreatic Cancer Invasion and Metastasis (2023)

&lt;div&gt;Abstract&lt;p&gt;Whereas interleukin-13 receptor α2 chain (IL-13Rα2) is overexpressed in a variety of human solid cancers including pancreatic cancer, we investigated its significance in cancer invasion and metastasis. We used two pancreatic cancer cell lines, &lt;i&gt;IL-13Rα2&lt;/i&gt;–negative HPAF-II and &lt;i&gt;IL-13Rα2&lt;/i&gt;–positive HS766T, and generated &lt;i&gt;IL-13Rα2&lt;/i&gt; stably transfected HPAF-II as well as &lt;i&gt;IL-13Rα2&lt;/i&gt; RNA interference knocked-down HS766T cells. Ability of invasion and signal transduction was compared between &lt;i&gt;IL-13Rα2&lt;/i&gt;–negative and &lt;i&gt;IL-13Rα2&lt;/i&gt;–positive cells and tumor metastasis was assessed in murine model for human pancreatic cancer with orthotopic implantation of tumors. IL-13 treatment enhanced cell invasion in &lt;i&gt;IL-13Rα2&lt;/i&gt;–positive cancer cell lines but not in &lt;i&gt;IL-13Rα2&lt;/i&gt;–negative cell lines. Furthermore, gene transfer of &lt;i&gt;IL-13Rα2&lt;/i&gt; in negative cell lines enhanced invasion, whereas its silencing downmodulated invasion of pancreatic cell lines in a Matrigel invasion assay. &lt;i&gt;In vivo&lt;/i&gt; study revealed that &lt;i&gt;IL-13Rα2&lt;/i&gt;–positive cancer metastasized to lymph nodes, liver, and peritoneum at a significantly higher rate compared with &lt;i&gt;IL-13Rα2&lt;/i&gt;–negative tumors. The expression of &lt;i&gt;IL-13Rα2&lt;/i&gt; in metastatic lesions was found to be increased compared with primary tumors, and mice with &lt;i&gt;IL-13Rα2&lt;/i&gt;–positive cancer displayed cachexia and poor prognosis. Invasion and metastasis also correlated with increased matrix metalloproteinase protease activity in these cells. Mechanistically, IL-13 activated extracellular signal-regulated kinase 1/2 and activator protein-1 nuclear factors in &lt;i&gt;IL-13Rα2&lt;/i&gt;–positive pancreatic cancer cell lines but not in &lt;i&gt;IL-13Rα2&lt;/i&gt;–negative cell lines. Taken together, our results show for the first time that IL-13 can signal through IL-13Rα2 in pancreatic cancer cells and &lt;i&gt;IL-13Rα2&lt;/i&gt; may serve as a prognostic biomarker of invasion and metastasis in pancreatic cancer. [Cancer Res 2009;69(22):8678–85]&lt;/p&gt;&lt;/div&gt;
Comparative Proteomics Analysis of Vascular Smooth Muscle Cells Incubated with S- and R-Enantiomers of Atenolol Using iTRAQ-coupled Two-dimensional LC-MS/MS (2008)

Atenolol is a beta(1)-selective drug, which exerts greater blocking activity on beta(1)-adrenoreceptors than on beta(2)-adrenoreceptors, with the S-enantiomer being more active than R-enantiomer. The aim of this study was to investigate the proteins with differential protein expression levels in the proteome of vascular smooth muscle cells (A7r5) incubated separately with individual enantiomers of atenolol using an iTRAQ-coupled two-dimensional LC-MS/MS approach. Our results indicated that some calcium-binding proteins such as calmodulin, protein S100-A11, protein S100-A4, and annexin A6 were down-regulated and showed relatively lower protein levels in cells incubated with the S-enantiomer of atenolol than those incubated with the R-enantiomer, whereas metabolic enzymes such as aspartate aminotransferase, glutathione S-transferase P, NADH-cytochrome b(5) reductase, and alpha-N-acetylgalactosaminidase precursor were up-regulated and displayed higher protein levels in cells incubated with the S-enantiomer relative to those incubated with the R-enantiomer. The involvement of NADH-cytochrome b(5) reductase in the intracellular anabolic activity was validated by NAD+/NADH assay with a higher ratio of NAD+/NADH correlating with a higher proportion of NAD+. The down-regulation of the calcium-binding proteins was possibly involved in the lower intracellular Ca2+ concentration in A7r5 cells incubated with the S-enantiomer of atenolol. Ca2+ signals transduced by calcium-binding proteins acted on cytoskeletal proteins such as nestin and beta-tropomyosin, which can play a complex role in phenotypic modulation and regulation of the cytoskeletal modeling. Our preliminary results thus provide molecular evidence on the metabolic effect and possible link of calcium-binding proteins with treatment of hypertension associated with atenolol.
Transcriptional regulation of the cholesterol biosynthetic pathway in male germ cells (2003)

Expression of cholesterogenic genes in somatic cells generally follows cholesterol level-sensitive negative feedback loop. In contrast, expression of genes involved in cholesterol biosynthesis in male germ cells is insensitive to the negative cholesterol feedback regulation. The pathway is regulated at the level of transcription by transcription factors of the sterol regulatory element-binding protein (SREBP) family. It was proposed that SREBPs do not play a significant role in transcriptional regulation of cholesterol synthesis in male germ cells, in which the accumulation of cholesterol biosynthesis intermediates with signalling properties (sterols MAS) and predomination of the cAMP-dependent signalling cascade was clearly established. Male germ cells do not grow in a clean primary culture, which is a limiting factor in experimental approaches. We have thus developed an ex vivo system, with the aim to simulate the cholesterol biosynthesis conditions in the testis. The level of transcription factors SREBPs in human choriocarcinoma cell line JEG-3 was reduced by growing cells in cholesterol/fatty acid rich media. The trans-activation by the cAMP-dependent pathway was achieved by forskolin and overexpressing transcription factor CREB. The simulation was only partially successful. cAMP-stimulation in cholesterol-repressed conditions lead to a decrease in cholesterol quantity, which is in accordance with metabolism of male germ cells that are not efficient in producing cholesterol de novo. In contrary to expectations, activation of the cAMP-dependent pathway did not result in a change of sterol composition and quantity. The role of SREBPs in spermatogenic cells was a puzzle until recently, when a soluble, 55 kDa cholesterol-insensitive form of SREBP2 (SREBP2gc), translated from a germ cell-specific SREBP2 mRNA, was discovered (Wang H. et. al., Mol. Cell. Endo 22, 8478-8490, 2002), . Our RT-PCR results also showed that SREBP2 as well as SREBP1c mRNAs are detectable in prepubertal and post-pubertal male germ cells while SREBP1a is not detected. Surprisingly, three SREBP2 immunoreactive proteins (72, 63 and 55 kDa), that are not present in mouse liver nuclei, reside in testis nuclei of prepubertal and adult mice. The 55 kDa protein is likely SREBP2gc, the other two isoforms are novel. HPLC measurements in liver and testes of fasted prepubertal and post-pubertal mice showed no significant difference in cholesterol level. However, FF-MAS and lanosterol/T-MAS intermediates that are detectable mainly in testis increase in fasted post-pubertal mice which coincides well with the elevated level of 68 kDa SREBP2. Similar to SREBP2gc, the two novel SREBP2 immunoreactive proteins seem to be insensitive to the level of cholesterol. In conclusion, it seems possible that cholesterol-independent forms of SREBPs together with cAMP-dependent stimuli, contribute to accumulation of cholesterogenic intermediates, the signaling sterols MAS.
SAW injection locked oscillators: dynamic behaviour and application to neural networks (1993)

The characteristics of an injection-locked oscillator are examined in two parts. Part A covers the dynamic behaviour of a surface acoustic wave injection-locked oscillator and its similarity near lock-in to that of an acousto-optic modulator. It is shown that a reflective wave component travels between the injected source and the oscillator resulting in periodic locking and unlocking of tile system. These reflected waves are responsible for the classical modulation sidebands near lock-in. In part B a SAW based neural network that can associate, categorize and store input stimuli is presented. The network can be modelled as a modified Kohonen self-organizing feature map
[Endogenous opioid peptides in cattle during pregnancy, birth and the newborn period]. (1991)

The concentrations of beta-endorphin and met-enkephalin in plasma were investigated in cows in different stages of gestation, during parturition and in the early postpartum period as well as in their newborn calves. Plasma beta-endorphin concentrations were low in the early stages of pregnancy. In the last month of gestation beta-endorphin levels almost as high as during parturition were found. Therefore in cattle the antepartum increase in plasma beta-endorphin concentration is not linked to the onset of labour. Met-enkephalin levels in plasma of calving cows were higher than those in cows in the last month of gestation. For met-enkephalin a relation to the stress of parturition is more likely than for beta-endorphin. In conjunction with a cesarean section the concentrations of beta-endorphin and met-enkephalin in plasma increased during surgery. This increase is likely to be caused by surgery-related stress. Calves showed highest beta-endorphin concentrations immediately after delivery. One hour post natum beta-endorphin levels were markedly decreased and showed only minor changes thereafter. In calves born at term highest met-enkephalin concentrations were found immediately post natum with levels decreasing continuously over the first two days of life. Preterm calves showed lower met-enkephalin concentrations in plasma than those born at term. During the first hour post natum in preterm animals met-enkephalin levels in plasma even increased. A highly significant correlation existed between met-enkephalin levels and the degree of acidosis in calves. An antagonism between endogenous opioids and catecholamines in newborns is suggested.
ChemInform Abstract: STEREOSPECIFIC COBALT‐MEDIATED ENEDIYNE CYCLIZATION INVOLVING A TETRASUBSTITUTED DOUBLE BOND: ONE‐STEP CONSTRUCTION OF THE HYDROPHENANTHRENE NUCLEUS INCORPORATING TWO ADJACENT QUATERNARY CENTERS (1985)

Abstract Aus dem Alkinol‐ether (I ) erhält man nach Metallierung mit dem Brpmid (II) den Diether (IIIa), der zu (IIIb) gespalten wird.
A mouse model of lung cancer induced via intranasal injection for anticancer drug screening and evaluation of pathology (2022)

The pathologies and lethality of lung cancers are associated with smoking, lifestyle, and genomic factors. Several experimental mouse models of lung cancer, including those induced via intrapulmonary injection and intratracheal injection, have been reported for evaluating the pharmacological effect of drugs. However, these models are not sufficient for evaluating the efficacy of drugs during screening, as these direct injection models ignore the native processes of cancer progression in vivo, resulting in the inadequate pathological formation of lung cancer. In the present study, we developed a novel intranasal injection model of lung cancer simulating the native lung cancer pathology for anticancer drug screening. A mouse lung cancer cell line (Lewis lung carcinoma; LCC) was intranasally injected into mouse lungs, and injected cell number-dependent cancer proliferation was apparent in both the left and right lungs. Human non-small-cell lung cancer (NCI-H460) cells were also intranasally injected into nude mice and similarly showed injected cell number-dependent cancer growth. For the pharmacological evaluation of cisplatin, two different treatment frequencies were tested four times per month and twice a month. The intranasal injection model confirmed that cisplatin suppressed lung cancer progression to a greater extent under the more frequent treatment condition. In conclusion, these results indicated that our intranasal injection model is a powerful tool for investigating lung cancer pathology and may aid in the development of new anti-lung cancer agents.
Low temperature methanol process (1986)

The world's abundant natural gas resources could provide methanol in fuel quantities to the utility system. Natural gas liquefaction is the current major option available for international export transport of natural gas. Gas production is on the increase and international trade even more so, with LNG making most progress. The further penetration of natural gas into distant markets can be substantially increased by a new methanol synthesis process under development. The new methanol process is made possible by the discovery of a catalyst that drops synthesis temperatures from about 275/sup 0/C to about 100/sup 0/C. Furthermore, the new catalyst is a liquid phase system, which permits the synthesis reaction to proceed at fully isothermal conditions. Therefore, the new low temperature liquid catalyst can convert synthesis gas completely to methanol in a single pass through the methanol synthesis reactor. This characteristic leads to a further major improvement in the methanol plant. Atmospheric nitrogen can be tolerated in the synthesis gas, and still the volume of gas fed to the reactor can be smaller than the volume of gas that must be fed to the reactor when accommodating the very low conversions furnished by the best of currently available catalysts. The energymore » disadvantage of the methanol option must be balanced against the advantage of a much lower capital investment requirement made possible by the new BNL synthesis. Preliminary estimates show that methanol conversion and shipping require an investment for liquefaction to methanol, and shipping liquefied methanol that can range from 35 to 50% of that needed for the LNG plant and LNG shipping fleet.« less
Solid Oxide Fuel Cell Stack For Transportation and Stationary Applications (2009)

Delphi is developing Solid Oxide Fuel Cell (SOFC) technology for applications in a variety of markets. This paper outlines the development of SOFC stacks for transportation and stationary applications. This paper outlines key achievements in stack development in moving forward towards meeting the goals for commercialization.
EVALUATION OF ION-EXCHANGE PROPERTIES OF FERRIC-HYDROXIDE FLOCS FOR THE REMOVAL OF HEAVY METAL WASTES USING A HIGH GRADIENT MAGNETIC SEPARATOR (1984)

Preliminary adsorption studies showed no effect on the effluent heavy metals with a magnetite dose of 500 or 1000 mg/l but removal was lower when 200 mg/l of magnetite was used. Adsorption of metals onto ferric flocs was found to be independent of initial heavy metals concentration provided the surface available for adsorption of ions was not saturated. As surface area coverage approached saturation percent removal of heavy metals decreased. The pH of the medium was found to have a major infuence on the removal of heavy metals. A 99.9% removal of all heavy metals could be achieved at pH values greater than 10.30 - 10.50, but removal was almost totally due to precipitation. Ferric sulphate made removal of heavy metals in a HGMS possible at lower pH values than 10.30 - 10.50. Increased magnetic field strength caused more removal of flocs for a given flow rate whereas an increase in flow rate decreased removal of flocs in a HGMS. The effect of treatment column diameters was geometric in that an increase in tube diameter caused more floc to be trapped because more entrapment area was available. The mg /in('3) of floc removed in each tube tested was the same at constant flow rate and magnetic field strength. The floc trapped in the HGMS was removed, by turning off the magnetic field, so it could be processed for recycle of the ferric ion. On the average of 671.3 mgms of 0.1N H(,2)SO(,4) were added to the floc to produce a pH of 3.10 - 3.57. A separatory funnel was used to separate the brown-black bottom layer, containing recovered ferric hydroxide-magnetite, from the colourless top layer containing the concentrated heavy metals. The ferric hydroxide was then reused to treat a fresh batch of wastewater and the cycle repeated four times. The loss of ferric ion was between 5 - 10% during each cycle.
On the in Vitro Biocompatibility Testing of Bioactive Glasses (2020)

In this work, a new 3D cellular model-based on human bone marrow mesenchymal stem cells (BM-MSCs)-was used for the first time to test the 45S5 Bioglass<sup>®</sup> (45S5). Such a model, previously used to evaluate the biologic performance of two novel bioactive glasses, suggested out the regenerative potential of such materials. In fact, BM-MSCs were able both to adhere and colonize the biomaterials, as well as differentiate toward osteoblasts-even in absence of specific growth factors. Surprisingly, BM-MSCs were not able to colonize 45S5 granules (almost no adhesion and/or colonization was observed), and thus, were not capable of providing any osteogenic differentiation. Therefore, the model seems to suggest that the two novel bioactive glasses have a better biologic performance than 45S5. If this hypothesis is confirmed also by in vivo tests, the 3D model may become a predictive tool for discriminating between different potential bioactive materials by comparatively evaluating them, and preliminarily selecting the best ones in relation to their biocompatibility potential-before proceeding with further experiments in vivo. This approach could favor the reduction of costs and time of pre-clinical and clinical trials.
Biochemistry and physiology of carbohydrates in the renal collecting duct (1997)

Using 13C-NMR analysis of cell extracts, enzymatic determination of metabolites and cofactors as well as enzyme assays on cell homogenates aerobic and anaerobic glycolysis, sorbitol formation by aldose reductase, the pentose phosphate shunt, and gluconeogenesis could be identified as the major pathways of D-glucose metabolism in renal inner medullary collecting ducts. In flux studies it was shown that D-glucose enters the collecting duct cells via a sodium-independent, cytochalasin- and phloretin-inhibitable transport system located at the basal-lateral cell side. At the same side sorbitol leaves the cells during regulatory volume decrease in a calcium-calmodulin-dependent fashion. From cell isolation studies it is proposed that sorbitol is taken up by adjacent (interstitial) cells, converted into fructose and then recycled to the collecting duct cells. This cycle might prevent carbohydrate wasting. Thus, IMCD cells exhibit unique aspects of carbohydrate biochemistry and physiology which enable them to function in a surrounding of low oxygen tension, low substrate supply, and extreme changes in extracellular osmolality.