gebhart/patrepeval huggingface dataset:
Chromic transitions in cross-polymerized poly(α,ι-alkadiyne) macromonomers (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChromic transitions in cross-polymerized poly(α,ι-alkadiyne) macromonomersR. J. Butera, B. Simic-Glavaski, and J. B. LandoCite this: Macromolecules 1990, 23, 1, 211–218Publication Date (Print):January 1, 1990Publication History Published online1 May 2002Published inissue 1 January 1990https://pubs.acs.org/doi/10.1021/ma00203a036https://doi.org/10.1021/ma00203a036research-articleACS PublicationsRequest reuse permissionsArticle Views33Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Computer Controlled Integrated Steering / Drive System for Vehicles (1996)

Abstract This paper discusses how a computer controlled four-wheel-steering (4WS) system can be used to increase the ability, namely low speed stability and traction as well as increased manoeuvrability of four-wheel-drive (4WD) vehicles. The essential feature of the integrated 4WS/4WD vehicle is that the path of the vehicle is selected via a joy stick or steering wheel, and a computer then controls the drive system of the two right hand wheels independently of the two left hand wheels, along with the positive rotation of the four wheels about vertical axes to the appropriate angles. Previous work by Spark and Besselink (1994a) relating to two wheel steering (2WS) / two wheel drive (2WD) systems will also be discussed briefly and expanded.
Design of Stereo Perception Systems for Automation of Off-road Vehicles (2007)

Localization and safeguarding are two basic functions that need to be integrated in intelligent machines. Global Navigation Satellite Systems (GNSS) such as GPS suffer from reliability problems caused by a lack of consistency in the signal that results in a necessity for sensor redundancy in vehicle localization. Perception, on the other hand, cannot be achieved through satellite systems and requires the aid of local sensors such as cameras, lasers or ultrasonics. Consequently, localization and safeguarding both benefit from local positioning and short-range perception. Stereo vision is becoming a preferred option to fulfill that mission due to the advantage of providing the three dimensional visualization of the targeted scene. However, it possesses the disadvantage of difficult data processing and handling, together with the absence of a systematic procedure to determine the most efficient system architecture. Because of the novelty of commercial solutions, there are no clear directions in terms of assembling stereo perception engines. The objective of this paper is to provide a set of recommendations on the configuration of stereo-based perception systems to assist intelligent off-road machines. To do so, several experiments were conducted in which different combinations of camera-lens-range were studied. Results showed that, in real-time applications, ranges up to 15 meters can be sensed with acceptable accuracy using off-the-shelf compact binocular cameras.
Endovascular stenting in transverse aortic arch hypoplasia (2013)

Stenting of transverse aortic arch hypoplasia, although technically challenging, produced good angiographic and haemodynamic results with an early improvement in blood pressure control. These results appear to be sustained in the medium term.
Recent Results Obtained with High Field, Internally Amplifying Semiconductor Radiation Detectors (1966)

Characterization of the gallium diffused junctions found useful as amplifying radiation detectors indicate a rather surprising window-junction depth relationship. The window, at only the self bias of the junction, has been measured to be a micron or so although the junction depth is ~50 microns. This is a result of the unusual diffusion process used - diffusion to 75 microns with subsequent removal of the heavily acceptor doped, first 25 micron region. Because of potential for low energy detection of these structures (which require thin windows) stress is placed upon window measurements. Measurements made of the response of these structures as photon detectors in the near infrared (0.7 - 1.1 micron) wavelength region are reported. Also initial results which indicate that the x-ray cutoff for these structures lies in the 44-60 Angstrom range.
Activation of Pre-mRNA Splicing by Human RNPS1 Is Regulated by CK2 Phosphorylation (2005)

Human RNPS1 was originally characterized as a pre-mRNA splicing activator in vitro and was shown to regulate alternative splicing in vivo. RNPS1 was also identified as a protein component of the splicing-dependent mRNP complex, or exon-exon junction complex (EJC), and a role for RNPS1 in postsplicing processes has been proposed. Here we demonstrate that RNPS1 incorporates into active spliceosomes, enhances the formation of the ATP-dependent A complex, and promotes the generation of both intermediate and final spliced products. RNPS1 is phosphorylated in vivo and interacts with the CK2 (casein kinase II) protein kinase. Serine 53 (Ser-53) of RNPS1 was identified as the major phosphorylation site for CK2 in vitro, and the same site is also phosphorylated in vivo. The phosphorylation status of Ser-53 significantly affects splicing activation in vitro, but it does not perturb the nuclear localization of RNPS1. In vivo experiments indicated that the phosphorylation of RNPS1 at Ser-53 influences the efficiencies of both splicing and translation. We propose that RNPS1 is a splicing regulator whose activator function is controlled in part by CK2 phosphorylation.
Relevance of Electrical Remodeling in Human Atrial Fibrillation (2012)

Prolonged P-wave duration, but not differences in atrial effective refractory periods, was associated with the development of atrial tachyarrhythmias in pacemaker patients.
A dual‐Kinect approach to determine torso surface motion for respiratory motion correction in PET (2015)

The method provides motion information with sufficiently high spatial and temporal resolution. Thus, it enables meaningful analysis in the form of comparisons between amplitudes and phase shifts of signals from different regions. In combination with a large field-of-view, as given by combining the data of two Kinect cameras, it yields surface representations that might be useful in the context of motion correction and motion modeling.
Design and Implementation of an Online Social Network with Face Recognition (2010)

This paper presents the idea of an online social network that makes use of the face recognition technology. With the technology, friend relationship can be established without the need of having the text-based information of a user, friend recommendation algorithm can be more accurate, and face tagging can be done automatically. The design and implementation issues of such system will be discussed. The prototype of our proposed social network will be demonstrated to show the feasibility of adopting the face recognition technology in online social networks.
A guided experimental approach to practical molecular pharmacology teaching: demonstration of sequence selectivity of DNA-binding drugs by arrested polymerase chain reaction (2000)

Here, we report a simple experimental approach for demonstrating sequence-selectivity of DNA-binding drugs by using the polymerase-chain reaction (PCR). The experiments described could be easily and reproducibly performed by medical and science students and biochemistry teachers, do not require complex or expensive instruments and 32P labelled probes or primers. The procedure described could represent a novel approach to practical biochemistry teaching in the field of biochemical pharma-cology.
Comprehensive Analysis of Circulating microRNA Specific to the Liver, Heart, and Skeletal Muscle of Cynomolgus Monkeys (2017)

Circulating microRNAs (miRNAs) could represent sensitive and specific biomarkers for tissue injury. However, their utility as biomarkers in nonclinical toxicological studies using nonhuman primates is limited by a lack of information on their organ specificity and circulating levels under resting condition of the animals. Herein, liver, heart, and skeletal muscle-specific expression patterns of miRNAs were determined in 27 tissues/organs from male and female monkeys (n =2/sex) by next-generation sequencing (NGS) analysis. This analysis revealed organ-specific miRNAs in the liver (miR-122), heart (miR-208a and miR-499a), and skeletal muscle (miR-206). Next, plasma was collected from conscious-naive male and female cynomolgus monkeys (n = 25/sex) to better understand the expressions of organ-specific circulating miRNAs. The absolute values of circulating miRNAs were quantified using a Taqman microRNA assay. MiR-1, miR-133a, and miR-208b showed preferential expression in the heart and skeletal muscles, whereas miR-192 was abundant in the liver, stomach, small intestine, and kidney. These miRNAs had identical sequences to their human counterparts. Six organ-specific miRNAs (miR-1, miR-122, miR-133a, miR-192, miR-206, and miR-499a) could be evaluated quantitatively by quantitative real-time reverse transcription polymerase chain reaction with or without preamplification. No significant sex differences were noted for these circulating miRNAs. For their circulation levels, miR-133a showed more than 900-fold interindividual variation, whereas miR-122 showed only a 20-fold variation. In conclusion, we profiled circulating organ-specific miRNAs for the liver, heart, and skeletal muscle of cynomolgus monkeys.
A real-time approach to autonomous novelty detection and object tracking in video stream (2011)

Recently, surveillance, security, patrol, search, and rescue applications increasingly require algorithms and methods that can work automatically in real time. This paper reports a new real-time approach based on three novel techniques for automatic detection, object identification, and tracking in video streams, respectively. The novelty detection and object identification are based on the newly proposed recursive density estimation (RDE) method. RDE is using a Cauchy-type of kernel, which is calculated recursively as opposed to the widely used (in particular in the kernel density estimation (KDE) approach) Gaussian one. The key difference is that the proposed approach works on a per frame basis and does not require a window (usually of size of several dozen) of frames to be stored in the memory and processed. It should be noted that the new RDE approach is free from user- or problem-specific thresholds by differ from the other state-of-the-art approaches. Finally, an evolving Takagi–Sugeno (eTS)-type fuzzy system is proposed for tracking. The proposed approach has been compared with KDE and Kalman filter (KF) and has proven to be significantly (in an order of magnitude) faster and computationally more efficient than RDE and more precise than KF.
Example of Structure Modeling and Analysis of Ultrasound Scattering for Trabecular Bone (2010)

Sciendo provides publishing services and solutions to academic and professional organizations and individual authors. We publish journals, books, conference proceedings and a variety of other publications.
MO-D-BRB-01: Stereotactic Body Radiation Therapy (SBRT) Using Respiratory-Gated Volumetric Modulated Arc Therapy (VMAT) with Flattening Filter Free (FFF) (2011)

Purpose: To evaluate treatment-plan quality and machine-delivery fidelity of SBRT using newly available respiratory-gated VMAT with FFF beams. Methods: Varian TrueBeam and Eclipse TPS systems were used for this study. Fifteen lung patients previously treated with SBRT using ungated 6MV WFF VMAT were selected. For each case, two gated SBRT VMAT plans with high dose rate FFF beams (1400 MU/min for 6 MV and 2400 MU/min for 10 MV) were created using the same constraints and isocenter as the original treatment plan. Each FFF plan was then delivered four times under different clinic-relevant respiratory conditions: without gating, and with gating (25%–70% phase cycle) for three different respiration periods (3, 4.5 and 6 seconds). Three independent methods, using a ScandiDos Delta4 device, a 27x27 ion chamber array (PTW-Seven29), and an adapted dose reconstruction technique based on delivery log-files, were employed to evaluate dose delivered by TrueBeam. A variety of dosimetric metrics such as homogeneity, conformity and gamma indices were used to assess the plans and deliveries. Results: Compared with the WFF plans, average target homogeneity of FFF plans was slightly improved by 5.5% while the average target conformity remained the same. No significant difference was observed in dose to the PTV and OARs (lungs, trachea, spinal cord, heart, esophagus, and chest wall). The mean of total MUs of 6 MV FFF plans was higher than that of WFF plans (3523 vs. 3161), however, with no statistical significance (p=0.53). Delta4 and Seven29 measurements and dose reconstruction demonstrated that the VMAT FFF plans for SBRT were faithfully realized under any of the four clinic-relevant delivery conditions, with high gamma-index passing rates (99.2%–100%) and measured/reconstructed dosimetric endpoints and distributions essentially identical with original plans. Conclusions: Respiratory-gated VMAT with high dose-rate FFF beams provides a reliable means for SBRT treatment of moving targets with high dosimetric fidelity.
Anatomical deformation due to horizontal rotation: towards gantry-free radiation therapy (2019)

Gantry-free radiation therapy systems may be simpler and more cost effective, particularly for MRI-guided photon or hadron therapy. This study aims to understand and quantify anatomical deformations caused by horizontal rotation with scan sequences sufficiently short to facilitate integration into an MRI-guided workflow. Rigid and non-rigid pelvic deformations due to horizontal rotation were quantified for a cohort of 8 healthy volunteers using a bespoke patient rotation system and a clinical MRI scanner. For each volunteer a reference scan was acquired at 0° followed by sequential faster scans in 45° increments through to 360°. All fast scans were registered to the 0° image via a three-step process: first, images were aligned using MR visible couch markers. Second, the scans were pre-processed then rigidly registered to the 0° image. Third, the rigidly registered scans were non-rigidly registered to the 0° image to assess soft tissue deformation. The residual differences after rigid and non-rigid registration were determined from the transformation matrix and the deformation vector field, respectively. The rigid registration yielded mean rotations of ⩽2.5° in all cases. The average 3D translational magnitudes range was 5.8 ± 2.9 mm-30.0 ± 11.0 mm. Translations were most significant in the left-right (LR) direction. Smaller translations were observed in the anterior-posterior (AP) and superior-inferior (SI) directions. The maximum deformation magnitudes range was: 10.0 ± 0.9 mm-28.0 ± 2.8 mm and average deformation magnitudes range: 2.3 ± 0.6 mm-7.5 ± 1.0 mm. Average non-rigid deformation magnitude was correlated with BMI (correlation coefficient 0.84, p = 0.01). Rigid pelvic deformations were most significant in the LR direction but could be accounted for with on-line adjustments. Non-rigid deformations can be significant and will need to be accounted for in order to facilitate the delivery of gantry-free therapy with an automated patient rotation system.
Whole-exome sequencing in relapsing chronic lymphocytic leukemia: clinical impact of recurrent RPS15 mutations (2015)

Fludarabine, cyclophosphamide, and rituximab (FCR) is first-line treatment of medically fit chronic lymphocytic leukemia (CLL) patients; however, despite good response rates, many patients eventually relapse. Although recent high-throughput studies have identified novel recurrent genetic lesions in adverse prognostic CLL, the mechanisms leading to relapse after FCR therapy are not completely understood. To gain insight into this issue, we performed whole-exome sequencing of sequential samples from 41 CLL patients who were uniformly treated with FCR but relapsed after a median of 2 years. In addition to mutations with known adverse-prognostic impact (TP53, NOTCH1, ATM, SF3B1, NFKBIE, and BIRC3), a large proportion of cases (19.5%) harbored mutations in RPS15, a gene encoding a component of the 40S ribosomal subunit. Extended screening, totaling 1119 patients, supported a role for RPS15 mutations in aggressive CLL, with one-third of RPS15-mutant cases also carrying TP53 aberrations. In most cases, selection of dominant, relapse-specific subclones was observed over time. However, RPS15 mutations were clonal before treatment and remained stable at relapse. Notably, all RPS15 mutations represented somatic missense variants and resided within a 7 amino-acid, evolutionarily conserved region. We confirmed the recently postulated direct interaction between RPS15 and MDM2/MDMX and transient expression of mutant RPS15 revealed defective regulation of endogenous p53 compared with wild-type RPS15. In summary, we provide novel insights into the heterogeneous genetic landscape of CLL relapsing after FCR treatment and highlight a novel mechanism underlying clinical aggressiveness involving a mutated ribosomal protein, potentially representing an early genetic lesion in CLL pathobiology.
<title>MT-compatible polymeric waveguide couplers for optoelectronic packaging</title> (2000)

Conventional optical packaging technologies cannot provide low-loss coupling among various mode-mismatched optoelectronic devices in a cost-effective manner. Our approach based on polymeric waveguide technology provides a unique solution that can alleviate the existing coupling losses among various optoelectronics components, including optical fibers, laser diodes, and photodetectors. In this work, the 3D tapered waveguide coupler was simulated to match MT connectors. According to this MT stand-off design, we fabricated and tested waveguide couplers in molded MT-RJ fiber connect ferrules and integrated optical cross-connects with fiber MT-like connectors. Three fabrication technologies for low-loss polymeric waveguides are also discussed here.
Characterization of the antigenic structure of human type II collagen (1996)

A series of 101 peptides each 20 amino acids in length (10-residue overlap) spanning the helical portion of the mature alpha-chain of human type II collagen (CII) was synthesized. DBA/1 (H-2q) mice were immunized with individual peptides, and draining lymph node cells were challenged in vitro. Strong responses were measured to three peptides: peptide I (residues 74-93), peptide 14 (residues 254-273), and peptide 81 (residues 924-943). B10.Q (H-2q) mice were responsive to peptides I and 81 but not to peptide 14. B10.RIII (H-2r) mice, which are resistant to arthritis induction following immunization with human CII, were unresponsive to peptides I, 14, and 81. Using single amino acid truncated peptides, we determined minimal immunostimulatory lengths for peptides I and 81. Residues critical to antigenicity were identified by introducing alanine and glycine substitutions into minimal length immunostimulatory peptides. The determinants within peptides I and 81 are 100% homologous to mouse CII and are autoantigens. Peptide 81 has homology to viral proteins. Peptide 14 is 90% homologous to mouse CII and has homology to heat shock proteins.
Induction of human T-cell tolerance to porcine xenoantigens through mixed hematopoietic chimerism (2004)

Xenotransplantation from pigs could provide a potential solution to the severe shortage of allogeneic donor organs. Because xenogeneic tissues are subject to vigorous immune rejection, tolerance induction is likely to be essential to the success of clinical xenotransplantation. Here we explore the possibility of inducing human T-cell tolerance to porcine xenografts through mixed chimerism. We previously showed that NOD/SCID-Tg mice expressing porcine cytokine transgenes permit the induction of durable porcine hematopoietic chimerism. In this study we achieved human T-cell development in these mice by engrafting human fetal thymus/liver tissues. In porcine hematopoietic chimeras, human thymus grafts were populated with porcine class II(high) cells in addition to human cells, and human T cells were tolerant of the porcine hematopoietic donor as measured by mixed lymphocyte reaction assay and skin grafting. This study proves the principle that porcine chimerism induces tolerance of xenoreactive human T cells.
A 0.55V Bandgap reference with a 59ppm/0c Temperature coefficient (2018)

This paper presents a novel low power, low voltage CMOS bandgap reference (BGR) that overcomes\nthe problems with existing BJT-based reference circuits, by using a MOS transistor operating in subthreshold\nregion. A proportional to absolute temperature (PTAT) voltage is generated by exploiting\nthe self-bias cascode branch, while a Complementary to Absolute Temperature (CTAT) voltage is\ngenerated by using the threshold voltage of the transistor. The proposed circuit is implemented in\n65nm CMOS technology. Post-layout simulation results show that the proposed circuit works with a\nsupply voltage of 0.55V, and generates a 286mV reference voltage with a temperature coefficient of\n59ppm/°C. The circuit takes 413nA current from 0.55V supply and occupies 0.00986mm2 of active\narea
Quantitative Anisotropic Analysis of Molecular Orientation in Amorphous N2O at 6 K by Infrared Multiple-Angle Incidence Resolution Spectrometry (2020)

The existence of molecular orientational order in nanometer-thick films of molecules has long been implied by surface potential measurements. However, direct quantitative determination of the molecular orientation is challenging, especially for metastable amorphous thin films at low temperatures. This study quantifies molecular orientation in amorphous N<sub>2</sub>O at 6 K using infrared multiple-angle incidence resolution spectrometry (IR-MAIRS). The intensity ratio of the weak antisymmetric stretching vibration band of the <sup>14</sup>N<sup>15</sup>NO isotopomer between the in-plane and out-of-plane IR-MAIRS spectra provides an average molecular orientation angle of 65° from the surface normal. No discernible change is observed in the orientation angle when a different substrate material is used (Si and Ar) at 6 K or the Si substrate temperature is changed in the range of 6-14 K. This suggests that the transient mobility of N<sub>2</sub>O during physisorption is key in governing the molecular orientation in amorphous N<sub>2</sub>O.