gebhart/patrepeval huggingface dataset:
Staged Surgery for Chronic Primary Aortoduodenal Fistula in a Septic Patient (2004)

Aortoenteric fistula is one of the most challenging problems that confront the vascular surgeons. Controversy remains over the optimal treatment because of the continued publication of series with high mortality, amputation, and aortic disruption rates. A positive preoperative blood culture is the best predictor of mortality with increased amputation rates due to infection of the extra-anatomic bypass. Therefore, in selected cases with sepsis, a prudent management protocol is required. We report a 68-yr-old male presenting with a chronic primary aortoduodenal fistula extensively involving the duodenum and Gram-negative sepsis. We planned a staged operation. Initially, an emergency laparotomy and control of the aorta allowed stabilization of the patient, identification of the fistula, and direct in situ placement of the prosthetic graft followed by an en bloc resection of the aneurysm and the surrounding structures. After he recovered from sepsis and had been stabilized, a staged extra-anatomic bypass followed by transabdominal removal of the temporarily placed graft was done. This management plan will allow the highest success rate and may be a prudent management protocol for these difficult cases.
Results of the VMAC Trial: Vasodilation in the Management of Acute Congestive Heart Failure (2000)

for the AMIOVIRT Investigators
Integrated silicon microbeam PI-FET accelerometer (1982)

Integrated accelerometers showing excellent linearity have been designed and fabricated using silicon planar technology, zinc-oxide sputtering, and anisotropic etching. Small cantilevered beam structures overcoated with piezoelectric ZnO films act as force transducers, and the electrical signal is directly coupled to the gate of a depletion-mode, p-channel MOS transistor. The accelerometers have a nearly flat response from very low frequencies until beam resonances become significant (above 40 kHz). The near-dc response results from completely isolating the piezoelectric film from electrical leakage paths. Measured performance has matched very well with theory. Theoretical analysis has been used to derive useful design tradeoffs.
Abstractions of Euler Diagrams (2005)

Euler diagrams are a graphical means to represent information. Providing an abstraction captures the pertinent information precisely, ignoring irrelevant details (where relevancy is dependent upon the application domain). We present two new abstractions and show that these are equivalent to a standard existing (zone-based) representation. Examples illustrate the potential usefulness of different abstractions in various areas, such as: identifying properties like nestedness or drawability, expressing the semantics in a more readable manner, and in the layout of diagrams.
The association of pp125FAK, pp60Src, CDC42Hs and Rap1B with the cytoskeleton of aggregated platelets is a reversible process regulated by calcium (1995)

The integrin alpha IIb beta 3-mediated redistribution of the tyrosine kinases pp125FAK and pp60Src and the small GTP-binding proteins CDC42Hs and Rap1B from the membrane skeleton to the cytoskeleton was found to be reversible: upon prolonged platelet aggregation (up to 15 min) induced by the thrombin-receptor activating peptide (TRAP) these signalling proteins dissociated from the cytoskeleton and reappeared in the membrane skeleton. Addition of the extracellular Ca2+ chelator EGTA and the intracellular Ca2+ chelator BAPTA/AM 30 s after TRAP allowed platelet aggregation and the association of pp125FAK, pp60Src, CDC42Hs and Rap1B with the cytoskeleton, but prevented their dissociation from the cytoskeleton. The results indicate that the prolonged elevation of cytosolic Ca2+ in stimulated platelets leads to the dissociation of signalling proteins from the cytoskeleton.
Metallacarboranes of Main Group, Transition, and Lanthanoid Elements: Syntheses, Structures and Reactivities (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Pegylated interferon‐alpha2a/ribavirin treatment of recurrent hepatitis C after liver transplantation (2008)

Hepatitis C virus (HCV) infection invariably recurs after liver transplantation (LT), leading to significant morbidity and mortality. Although the combination of pegylated interferon-alpha (IFN-alpha)/ribavirin is the preferred treatment for these patients, the optimal schedule remains undetermined. In an uncontrolled trial, 19 patients with HCV infection recurring after LT received pegylated IFN-alpha(2a), 180 mug weekly, and ribavirin, 10 mg/kg body weight daily, for 48 weeks. The proportion of patients with undetectable HCV RNA in their serum after 12 weeks of treatment was 53%. Five patients (26%) dropped out of the study due to intolerance (in 2 cases), depression (in 1), or infectious complications (in 2). A sustained virological response (SVR), defined as undetectable serum HCV RNA 24 weeks after the end of treatment, was observed in 9/19 patients (47%). SVR was associated with an early virological response after 12 weeks of therapy (P<0.001) and a treatment duration >80% (P=0.02), but not with baseline HCV RNA level or a cumulative dose of pegylated IFN-alpha(2a) or ribavirin >80% of the scheduled dose. All 4 patients with genotype 2 or 3 reached SVR, as compared with 33% of patients with genotype 1 or 4 (P=0.03). A 48-week course of pegylated IFN-alpha(2a)/ribavirin therapy is effective in patients with recurrent HCV infection after LT.
EFFECTS OF AGE, HEALTH-RELATED QUALITY OF LIFE, AND EDUCATION LEVEL ON MANAGEMENT AFTER BIOCHEMICAL FAILURE WITH WATCHFUL WAITING VERSUS HORMONAL THERAPY IN MEN WITH PROSTATE CANCER: RESULTS FROM THE COMPARE REGISTRY (2008)

You have accessJournal of Urology1 Apr 2008EFFECTS OF AGE, HEALTH-RELATED QUALITY OF LIFE, AND EDUCATION LEVEL ON MANAGEMENT AFTER BIOCHEMICAL FAILURE WITH WATCHFUL WAITING VERSUS HORMONAL THERAPY IN MEN WITH PROSTATE CANCER: RESULTS FROM THE COMPARE REGISTRY Charles L Bennett, Oliver Sartor, David G McLeod, and Susan Halabi Charles L BennettCharles L Bennett More articles by this author , Oliver SartorOliver Sartor More articles by this author , David G McLeodDavid G McLeod More articles by this author , and Susan HalabiSusan Halabi More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(08)60317-1AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "EFFECTS OF AGE, HEALTH-RELATED QUALITY OF LIFE, AND EDUCATION LEVEL ON MANAGEMENT AFTER BIOCHEMICAL FAILURE WITH WATCHFUL WAITING VERSUS HORMONAL THERAPY IN MEN WITH PROSTATE CANCER: RESULTS FROM THE COMPARE REGISTRY." The Journal of Urology, 179(4S), p. 109 © 2008 by American Urological AssociationFiguresReferencesRelatedDetails Volume 179Issue 4SApril 2008Page: 109 Advertisement Copyright & Permissions© 2008 by American Urological AssociationMetrics Author Information Charles L Bennett More articles by this author Oliver Sartor More articles by this author David G McLeod More articles by this author Susan Halabi More articles by this author Expand All Advertisement PDF downloadLoading ...
Abstract 048: Changes In Bile Acid Metabolism, Circulating MicroRNA-34a, And Improvements In Lipid Profiles In Response To Weight-loss Diets: The Pounds Lost Trial (2022)

Background: Bile acids are synthesized from cholesterol in the liver and play pivotal roles in nutrient absorption and metabolic regulation. Altered bile acid metabolism is related to dyslipidemia, and microRNA-34a (miR-34a) may play a pivotal role in the treatment of lipid homeostasis by regulating the bile acid biosynthesis. Hypothesis: We investigated whether weight-loss diet-induced changes in primary and secondary bile acids were associated with the improvements in lipid profiles. We also tested the role of circulating miR-34a in the altered bile acid metabolism in adults with overweight and obesity. Methods: A total of 520 participants of a weight-loss dietary intervention (the POUNDS Lost trial) with data on bile acids and miR-34a were included in the present analysis. Circulating levels of miR-34a and bile acid subtypes (primary and secondary unconjugated bile acids and their taurine-/glycine-conjugates) were measured at baseline and 6 months after the intervention. Outcome measurements were improvements in lipids (triglycerides and cholesterol) in response to the interventions. Results: At baseline, higher levels of primary bile acids (chenodeoxycholate (CDCA), glycocholate (GCA), taurocholate (TCA), and glycochenodeoxycholate (GCDCA) were associated with elevated levels of triglycerides ( P FDR &lt;0.05). Greater decreases in the primary bile acid subtypes (CDCA, GCA, TCA, GCDCA, and taurochenodeoxycholate [TCDCA]) in response to the interventions were significantly associated with larger reductions of triglycerides at 6 months ( P FDR &lt;0.05 for all). Decreases in secondary bile acids (deoxycholate and its conjugated forms) also showed significant associations with decreases in triglycerides. Similarly, reductions of total cholesterol at 6 months were associated with decreases in the primary (such as GCA, GCDCA, TCDCA) and secondary bile acid subtypes. We found that greater levels of miR-34a at baseline were related to higher levels of triglycerides at baseline (p=0.038) and higher levels of primary bile acids (such as CA, CDCA, GCA, and TCA [PFDR &lt;0.05 for all]) but not with the secondary bile acids at baseline. Further, weight-loss diet-induced changes in miR-34a were positively correlated with changes in the primary bile acid subtypes (CDCA, GCA, and GCDCA). Conclusions: Changes in the specific primary and secondary bile acid subtypes were related to the improvements in lipid profiles in response to weight-loss diet interventions. Circulating miR-34a might in part contribute to the alterations in the primary bile acid subtypes in obese adults.
Onco-Retroviral and Lentiviral Vector-Based Gene Therapy for Hemophilia: Preclinical Studies (2004)

Hemophilia A and B gene therapy requires long-term and stable expression of coagulation factor VIII (FVIII) or factor IX (FIX), respectively, and would need to compare favorably with protein replacement therapy. Onco-retroviral and lentiviral vectors are attractive vectors for gene therapy of hemophilia. These vectors have the potential for long-term expression because they integrate stably in the target cell genome. Whereas onco-retroviral vectors can only transduce dividing cells, lentiviral vectors can transduce a broad variety of cell types irrespective of cell division. Several preclinical and clinical studies have explored the use of onco-retroviral and, more recently, lentiviral vectors for gene therapy of hemophilia A or B. Both ex vivo and in vivo gene therapy approaches have been evaluated, resulting in therapeutic FVIII or FIX levels in preclinical animal models. Whereas in vivo gene therapy using onco-retroviral or lentiviral vectors often led to long-term FVIII or FIX expression from transduced hepatocytes, ex vivo approaches were generally hampered by either low or transient expression of FVIII or FIX levels in vivo and/or inefficient engraftment. Furthermore, immune responses against the transgene product remain a major issue that must be resolved before the full potential of these vectors eventually can be exploited clinically. Nevertheless, the continued progress in vector design combined with a better understanding of vector biology may ultimately yield more effective gene therapy approaches using these integrating vectors.
Deep Learning Applied to Multi-Structure Segmentation in 2D Echocardiography: A Preliminary Investigation of the Required Database Size (2018)

With the recent advances in machine learning, and their successful application to medical imaging, building medical databases big enough to learn to solve corresponding tasks for any given patient has become a priority. In this study, we set up a specific dataset of 500 patients to investigate the number of patients needed by two learning methods, the Structured Random Forest (SRF)and U-net, to obtain accurate segmentation results in 2D echocardiography. Our findings advocate that U-net is a good candidate to solve the still-open 2D echocardiography automatic segmentation problem.
The mniopetals, new inhibitors of reverse transcriptases from a Mniopetalum species (Basidiomycetes). I. Producing organism, fermentation, isolation and biological activities. (1994)

Six novel enzyme inhibitors of RNA-directed DNA-polymerases of human immunodeficiency-, avian myeloblastosis and murine leukemia viruses were isolated from fermentations of a canadian Mniopetalum species. They were named mniopetals A, B, C, D, E and F. Their structures were elucidated by spectroscopic methods. The compounds, in addition to their inhibitory activities on reverse transcriptases, exhibit antimicrobial and cytotoxic properties.
Zur Möglichkeit der Deduktion des Wirtschaftlichkeits- und Gewinnmaximierungsprinzips aus dem Rationalprinzip (2004)

In den Wirtschaftswissenschaften ist man gerade in ihrem traditionellen Kern bemüht, ihr Gebiet durch strenge Annahmen bzw. Axiomatisierung möglichst eindeutig festzulegen und abzugrenzen. Grundlegende Bedeutung kommt dabei dem Wirtschaftlichkeits- und Gewinnmaximierungsprinzip zu. Es kann jedoch gezeigt werden, dass ihre Begründung in Form einer Deduktion aus dem Rationalprinzip wissenschaftstheoretisch alles andere als überzeugend ist. Insbesondere das Gewinnmaximierungsprinzip basiert auf historischen sowie gesellschaftspolitischen Aspekten und ist vornehmlich normativer Natur.
Supplementary Figure 2 from Combination of Sulindac and Antimicrobial Eradication of <i>Helicobacter pylori</i> Prevents Progression of Gastric Cancer in Hypergastrinemic INS-GAS Mice (2023)

Supplementary Figure 2 from Combination of Sulindac and Antimicrobial Eradication of &lt;i&gt;Helicobacter pylori&lt;/i&gt; Prevents Progression of Gastric Cancer in Hypergastrinemic INS-GAS Mice
Spatial multiplexing applied to turbo coded multicarrier CDMA (2005)

We combine spatial multiplexing with a multi-carrier code division multiple access (MC-CDMA) system associated to a turbo coding (TC) scheme. MC-CDMA is likely to be a very promising access technique for future wireless communication systems. In fact, MC-CDMA exploits the advantages of both the multi-carrier modulation and code division multiple access (CDMA) technique. On the other hand, the capacity of a multi-antenna system can linearly increase with the minimum of transmit and receive antennas using spatial multiplexing. We study the concatenation of multiple input multiple output (MIMO) systems for N/sub t/ transmit and N/sub r/ receive antennas and MC-CDMA with a TC scheme. Simulation results are provided for different loads in order to demonstrate the efficiency of spatial multiplexing combined with the turbo channel coding scheme for a multiuser system based on MC-CDMA for both uncorrelated and correlated antenna systems.
Hypocapnia and the injured brain: Evidence for harm (2010)

Curley, Gerard MB, FCARCSI; Kavanagh, Brian P. MD, FRCPC; Laffey, John G. MD Author Information
Performance Analysis of UWB Timing Acquisition Schemes Based on RSS Measurements (2006)

The paper focuses on the performance analysis of the timing acquisition scheme based on received signal strength (RSS) measurements for ultra-wideband (UWB) communication systems. To our knowledge, few paper discusses the performance of the timing acquisition scheme based on RSS measurements for UWB in details. The timing acquisition scheme based on RSS measurements has many advantages, such as low cost, high speed and robustness. However, low transmission power limitation and complicated indoor multipath propagation environments make it difficult to measure accurate RSS at the receiver and affect the accuracy of the time delay offset estimation for the local template signals. In addition, the time variation of the indoor channel state can form a multiple-to-one mapping relation between the RSS measurements and the distance, which largely limits the method application. In the paper, we analyze the accuracy of time delay offset estimation for this method by deriving the Cramer-Rao lower bound (CRLB). The number results show that the accuracy of the timing acquisition method based on RSS measurements suffers from both the UWB signal transmission speed and the varying distance between the transmitter and receiver. It is noted that though the accuracy of the method can hardly fulfil the fine timing acquisition requirement for UWB systems, it will largely reduce the coarse timing acquisition time and improve the performance for UWB timing acquisition systems if combined with other timing acquisition ones
On the Achievable Rate of Stationary Rayleigh Flat-Fading Channels with\n Gaussian Inputs (2011)

In this work, we consider a discrete-time stationary Rayleigh flat-fading\nchannel with unknown channel state information at transmitter and receiver. The\nlaw of the channel is presumed to be known to the receiver. In addition, we\nassume the power spectral density (PSD) of the fading process to be compactly\nsupported. For i.i.d. zero-mean proper Gaussian input distributions, we\ninvestigate the achievable rate. One of the main contributions is the\nderivation of two new upper bounds on the achievable rate with zero-mean proper\nGaussian input symbols. The first one holds only for the special case of a\nrectangular PSD and depends on the SNR and the spread of the PSD. Together with\na lower bound on the achievable rate, which is achievable with i.i.d. zero-mean\nproper Gaussian input symbols, we have found a set of bounds which is tight in\nthe sense that their difference is bounded. Furthermore, we show that the high\nSNR slope is characterized by a pre-log of 1-2f_d, where f_d is the normalized\nmaximum Doppler frequency. This pre-log is equal to the high SNR pre-log of the\npeak power constrained capacity. Furthermore, we derive an alternative upper\nbound on the achievable rate with i.i.d. input symbols which is based on the\none-step channel prediction error variance. The novelty lies in the fact that\nthis bound is not restricted to peak power constrained input symbols like known\nbounds, e.g. in [1]. Therefore, the derived upper bound can also be used to\nevaluate the achievable rate with i.i.d. proper Gaussian input symbols. We\ncompare the derived bounds on the achievable rate with i.i.d. zero-mean proper\nGaussian input symbols with bounds on the peak power constrained capacity given\nin [1-3]. Finally, we compare the achievable rate with i.i.d. zero-mean proper\nGaussian input symbols with the achievable rate using synchronized detection in\ncombination with a solely pilot based channel estimation.\n
Gla-Rich Protein Is a Potential New Vitamin K Target in Cancer: Evidences for a Direct GRP-Mineral Interaction (2014)

Gla-rich protein (GRP) was described in sturgeon as a new vitamin-K-dependent protein (VKDP) with a high density of Gla residues and associated with ectopic calcifications in humans. Although VKDPs function has been related with γ-carboxylation, the Gla status of GRP in humans is still unknown. Here, we investigated the expression of recently identified GRP spliced transcripts, the γ-carboxylation status, and its association with ectopic calcifications, in skin basal cell and breast carcinomas. GRP-F1 was identified as the predominant splice variant expressed in healthy and cancer tissues. Patterns of γ-carboxylated GRP (cGRP)/undercarboxylated GRP (ucGRP) accumulation in healthy and cancer tissues were determined by immunohistochemistry, using newly developed conformation-specific antibodies. Both GRP protein forms were found colocalized in healthy tissues, while ucGRP was the predominant form associated with tumor cells. Both cGRP and ucGRP found at sites of microcalcifications were shown to have in vitro calcium mineral-binding capacity. The decreased levels of cGRP and predominance of ucGRP in tumor cells suggest that GRP may represent a new target for the anticancer potential of vitamin K. Also, the direct interaction of cGRP and ucGRP with BCP crystals provides a possible mechanism explaining GRP association with pathological mineralization.
Analysis of phase noise and cnr degradation of externally generated lo signal in lnb for ku-band dvb-s systems by heterodyning two lasers (2009)

We investigate the externally generation of an LO signal by optical heterodyning, which is then distributed to each of the mixers at every antenna element of a phased array antenna used for standard DVB-S (digital Video Broadcasting-Satellite) reception system. The system1 is presented in Figure 1. The Ku-Band (10.7 GHz ~12.75 GHz) RF signal from the antenna array is amplified and then down converted to IF (950 MHz to 2150 MHz) at the mixer by a 9.75 GHz LO signal generated by optical heterodyning
Research on Cloud-Based Mass Log Data Management Mechanism (2014)

In this paper, we study the file management mechanism of large-scale cloud-based log data. With the rise of big data, there are more and more the Hadoop-based applications. Log analysis is an important part of network security management, but the existing network log analysis system can’t deal with huge amounts of log data, or only use offline mode which with a longer response delay. Therefore, building the online Hadoop-based log processing system is necessary. However, how to effectively manage vast amounts of log data have become the key problems of such system. To this end, this paper puts forward a new hierarchical file archiving (HFA) mechanism which can realize the hierarchical and sorted storage of massive amounts of log data. In addition, some feasible methods for the mechanism are also proposed. Through the HFA mechanism, the traditional log analysis mode and Hadoop-based offline analysis mode can be combined to achieve the online Hadoop-based log analysis system, which have good scalability that can effectively store and handle the massive log data, and faster response speed for user request to meet the requirements of online processing. The feasibility and effectiveness of the HFA mechanism have been verified by the experiment of a small log process system.
Camera calibration from orthogonally projected coordinates with noisy-RANSAC (2009)

We introduce a formulation for ¿orthogonal calibration¿ which is to extract camera calibration parameters from the world coordinates with unknown heights. Such coordinates can be obtained from an aerial photograph or a GPS device. A typical approach would be to introduce a planar surface assumption and apply the plane homography. However, the planar assumption often fails; moreover, the camera parameters recovered from a homography matrix is highly sensitive to noise. We introduce a formulation for the orthogonal calibration which is similar to the fundamental matrix equation. Based on the formulation, we introduce a 6-point algorithm to recover the rotation and translation and a 7-point algorithm to recover the focal lengths in addition. Then, we introduce a noisy-RANSAC method which enables robust parameter recovery from a small number of point correspondences. The noisy-RANSAC naturally incorporates the orthogonal calibration and any available information on the scene structure, which delivers much improved estimates. Experimental results on synthetic datasets and an example application to a real image are presented.