gebhart/patrepeval huggingface dataset:
EFFECT OF CHITOSAN ON HUMAN DERMAL FIBROBLASTS IN VITRO: EVIDENCE FOR TWO DONOR-DEPENDENT POPULATIONS OF FIBROBLASTS (2000)

Conference Abstract| June 01 2000 EFFECT OF CHITOSAN ON HUMAN DERMAL FIBROBLASTS IN VITRO: EVIDENCE FOR TWO DONOR-DEPENDENT POPULATIONS OF FIBROBLASTS G. Howling; G. Howling *School of Biochemistry & Molecular Biology, University of Leeds, Leeds LS2 9JT Search for other works by this author on: This Site PubMed Google Scholar P. Dettmar; P. Dettmar †Reckitt & Colman Products, Hull, HU8 7DS, UK Search for other works by this author on: This Site PubMed Google Scholar P. A. Goddard; P. A. Goddard †Reckitt & Colman Products, Hull, HU8 7DS, UK Search for other works by this author on: This Site PubMed Google Scholar F. C. Hampson; F. C. Hampson †Reckitt & Colman Products, Hull, HU8 7DS, UK Search for other works by this author on: This Site PubMed Google Scholar J. M. Dornish; J. M. Dornish **Pronova Biomedical, Oslo, Norway. Search for other works by this author on: This Site PubMed Google Scholar E. J. Wood E. J. Wood *School of Biochemistry & Molecular Biology, University of Leeds, Leeds LS2 9JT Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (2000) 28 (3): A84. https://doi.org/10.1042/bst028a084c Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation G. Howling, P. Dettmar, P. A. Goddard, F. C. Hampson, J. M. Dornish, E. J. Wood; EFFECT OF CHITOSAN ON HUMAN DERMAL FIBROBLASTS IN VITRO: EVIDENCE FOR TWO DONOR-DEPENDENT POPULATIONS OF FIBROBLASTS. Biochem Soc Trans 1 June 2000; 28 (3): A84. doi: https://doi.org/10.1042/bst028a084c Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 2000 Biochemical Society2000 Article PDF first page preview Close Modal You do not currently have access to this content.
Nucleosides: XI. Synthesis and Antiviral Evaluation of 5'-Alkylthio-5'-deoxy Quinazolinone Nucleoside Derivatives as S-Adenosyl-L-homocysteine Analogs (2004)

4-amino-1-(beta-D-ribofuranosyl)quinazolin-2-one (3) was prepared by a direct glycosylation of 4-aminoquinazolin-2-one (7) using the Vorbruggen's silylation method and provided exclusively the beta-anomer. This quinazoline nucleoside and its 2',3'-O-isopropylidene derivative (9) did not undergo the coupling reaction with dialkyl disulfides in the presence of tri-n-butylphosphine unless their 4-amino groups were protected by N,N-dimethylaminomethylidene. This approach provides a viable alternative synthetic route to 5'-alkylthio-5'-deoxy nucleosides.
The natural sound field effect for multimedia contents (1999)

The method of modeling the sound field informing the acoustical features of the virtual spaces is described. The sound field effect can be implemented through the appropriate combination of the early and late reflections resulting from the parameters users set up. This paper shows the method to model the various sound fields to user's taste by computer simulation and the discussion of the results.
In-flight I-V results from the 2ndforward technology solar cell experiment (2014)

The 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">nd</sup> Forward Technology Solar Cell Experiment (FTSCE II) on board the International Space Station, measured I-V curves on advanced solar cells for 18 months. In this paper we discuss the data reduction methodology of in-flight measurements. Degradation rates, temperature coefficients for production III-V triple junction cells, inverted metamorphic prototype cells, and other experimental solar cells are discussed in a related IEEE Journal of Photovoltaics submission.
Finite Element Analysis of Wave Transmission through a Unidirectional Composite Layer (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Synthesis of regular computational fabrics with ambipolar CNTFET technology (2010)

In this paper, we report on a physical design of regular fabrics with ambipolar CNTFET devices. Three medium-grain size cells, built with ambipolar CNTFETs with in-field controllable polarities are evaluated. We designed regular layouts using these cells using 32nm technology rules and we performed technology mapping and routing of a set of benchmark circuits. CNTFET-based cells were then compared with an existent configurable cell of similar grain size, the Actel ACT1 logic brick, simulated with a 32nm MOSFET model. We obtained delays about 2× better than those obtained with ACT1 after normalization to the intrinsic technology delay. After technology mapping and routing steps, we report performances about 8× better in terms of area × normalized delay for the CNTFET-based cells over the Actel ACT1 cell.
Manufacturing ELT optics: Year 2 report (2019)

Green light for the construction of the 39-m aperture Extremely Large Telescope (ELT) was given by the Council of the European Southern Observatory (ESO) on Dec 4th, 2014. Procurement of the key elements, especially the optics, the dome and structure and the glass substrates, was soon after initiated by ESO team. Safran-Reosc is proud to have been awarded all the key optical polishing and testing contracts with M4 in 2015, M2 in 2016, M3 and M1 in 2017. This paper reports Safran-Reosc’s work progresses of the last 12 months along these four contracts with their challenges, specifically those related to the mass production of the M1 segments. Keywords: ELT, segmented optics, large optics, optical manufacturing, optical testing, thin glass shell, bonding
Kinetics of the acid-catalysed hydrolysis of dodecylsulphate and dodecyldiethoxysulphate surfactants in concentrated micellar solutions. Part 2.—Effects of added electrolytes on the hydrolysis of sodium dodecylsulphate and sodium dodecyldiethoxysulphate (1983)

The effects of electrolyte additives upon the rates of acid-catalysed hydrolysis of sodium dodecylsulphate (SDS) and sodium dodecyldiethoxysulphate (SDE2S) in relatively dilute micellar solutions (0.035 mol dm–3) and for SDS also in concentrated micellar solutions (0.35 mol dm–3) have been studied. In dilute micellar solutions all effects are inhibitory, with salts containing doubly charged cations (Mg and Ca) being more effective than those containing singly charged alkali and ammonium ions, for which the inhibition order is N(CH3)4 < Li < NH4 < Na < K < Cs. Theoretical treatment in terms of the pseudo-phase ion-exchange theory has led to estimates of ion-exchange equilibrium constants for displacement of hydrogen ions from the micellar surface by other cations. There are very good linear correlations of the logarithms of these constants for each surfactant with the hydrated ion radii (Stokes' radii) for alkali ions, as expected from the electrostatic theory of ion binding to the highly charged micellar surface. Unexpectedly, the effect of electrolytes upon the micellar-catalysed acid hydrolysis of SDS in concentrated solutions (0.35 mol dm–3) is not uniformly inhibitory. Potassium and caesium chlorides show a small inhibitory effect at low concentrations, but enhance rates at higher concentratrations. The order of inhibitory effects of alkali salts at low concentrations in these concentrated micellar solutions is the reverse of that observed in dilute micellar solutions. These effects can be explained if deviations from ideality of electrolytes in concentrated aqueous pseudo-phase are taken into account. The effects of salts containing doubly charged cations remain inhibitory, the sequence being Ni > Ca > Mg.
Abstract 2573: Combinations of QBI-139, a clinical stage ribonuclease drug (2011)

Abstract RNA has been recognized as a drug target for cancer therapy, as evidenced by the ongoing clinical trials of RNAi and antisense therapies. An alternative approach that circumvents the delivery and stability issues of RNAi and antisense is to harness the activity of naturally occurring enzymes that degrade RNA. The ribonuclease approach is partially validated by objective clinical responses seen in clinical trials of ribonuclease (RNase) discovered in frog eggs. Our research has focused on creating variants of human RNases with the ability of frog RNase to evade the human RNase inhibitor. Diminished binding of mammalian RNases to the inhibitor have been shown to endow the RNase with the ability to kill cancer cells. One of the RNase variants, called QBI-139, demonstrated particularly strong anti-cancer activity against a variety of tumor types in in vivo models. QBI-139 is differentiated from the frog RNase because QBI-139 is 95 % identical to a native human RNase, while the frog RNase is only 20% similar. This difference may be what has led to a significantly improved tolerability profile for QBI-139 across species. QBI-139 was selected for clinical development and is now in a Phase I trial of solid tumors. In charting the clinical development path for QBI-139, the ability of the RNase to work in combination with a variety of standard of care agents had to be evaluated. Based in the single agent activity of QBI-139 in colon, non-small cell lung, ovarian and pancreatic cancers, the potency of QBI-139 in combination with the standard of care agents for these indications was explored. In in vitro screening, QBI-139 has demonstrated additive and synergistic activity in combination with cisplatin, 5-FU and docetaxel. The treatments were evaluated using fixed ratios of QBI-139 and the combination drug based on their EC50 values. The Combination Index (CI) was determined using median effect analysis. A CI of 1 indicates additive effects, whereas a CI &amp;lt; 1 indicates synergy. Synergy was demonstrated with QBI-139 in combination with cisplatin against solid tumors of non-small cell lung cancer (A549 and H1975) and an additive effect in ovarian (Ovcar-3) cancer. 5-FU and docetaxel also were synergistic with QBI-139 against solid tumors of colon (HCT-116) and ovarian (SK-OV-3) cancer, respectively.The goal of this project is development of an innovative, differentiated therapy, QBI-139, to provide clinical benefit to patients with colon, non-small cell lung and ovarian cancer, which are among the seven deadliest forms of cancer in the United States. In addition to being serious diseases, effective treatment of these cancers also represent unmet medical needs. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2573. doi:10.1158/1538-7445.AM2011-2573
Comparison of alphabetic and phonetic retrieval of online drug information (1983)

Alphabetic, phonetic, and combined alphabetic and phonetic methods of retrieving online drug information were compared. Twenty-four volunteers participated in the study representing four user groups: physicians, nurses, pharmacists, and nonhealth-care hospital staff. Each subject performed 150 searches, 50 by each retrieval method. Using the alphabetic method, drug information was retrievable only if the drug name was spelled correctly. Using the phonetic method, searches were conducted based on the phonetic spelling of requests (e.g., ‘symetadine’ for cimetidine). The combined method used a phonetic search only after an initial alphabetic search was unsuccessful. The elapsed time between the first entry and an indication that the information had been found or could not be found was determined, and the number of drug names not found and the number of excess tries were counted. There were no significant differences in elapsed time among the three methods. Pharmacists had the shortest mean elapsed time and physicians the longest. The average number of excess tries using the phonetic system was a third of the number required using the alphabetic method. The number of drugs not found showed only slight differences among the three methods. The subjects found the desired information on the first try 67% of the time with the alphabetic method, 66% with the combined method, and 90% with the phonetic method. The phonetic method had an average of 75 matches versus 20 for the alphabetic and combined methods. These results support use of a combined alphabetic and phonetic system for retrieving drug information.
Security Vulnerabilities and Exposures in Internet Systems and Services (2005)

In order to guarantee a global security solution in network environments, it is necessary to take into account several issues such as security mechanisms for exchange and access to remote information; mechanisms for protection of networked systems and administrative domains; detection of new vulnerabilities and exposures; and monitoring and periodic audit of the implemented security mechanisms and disaster recovery plans.
Effects of a Lubricin-Containing Compound on the Results of Flexor Tendon Repair in a Canine Model in Vivo (2010)

Treatment with the lubricin-containing gel CHL appears to be an effective means of decreasing postoperative flexor tendon adhesions, but it is also associated with some impairment of tendon healing. Future studies will be necessary to determine if the positive effects of CHL on adhesion formation can be maintained while reducing its adverse effect on the structural integrity of the repaired tendon.
Re‐evaluation of nestin as a marker of oligodendrocyte lineage cells (2001)

Maturation of oligodendrocyte progenitors (O2A) is characterized by morphological changes and the sequential expression of specific antigens leading to the formation of myelin membrane. Monoclonal antibodies A2B5, A007, anti-vimentin, and anti-galactocerebroside, recognize oligodendroglia at different stages of development. The neuroepithelial precursor marker nestin is also expressed by the oligodendroglial lineage; we have used enriched populations of progenitors isolated from neonatal rat brain cultures to further examine the cellular distribution of this intermediate filament protein. The phenotypic distribution of nestin positive cells among the oligodendrocyte lineage showed that 65% reacted with A2B5, whereas only 5% were A007(+), and 4% galactocerebroside(+). The remaining 25% of the cells were not labeled and had small cellular bodies devoid of processes, characteristic of the pre-O2A progenitor. Further analysis of the nestin(+) population showed that the majority of the cells were also vimentin(+). Antibody-dependent complement mediated cytolysis of A2B5(+) (O2A cells) and galactocerebroside(+) (mature oligodendrocytes) cells left a population of nestin(+) cells that were induced to proliferate in the presence of growth factors and to differentiate into A2B5(+) and galactocerebroside(+) cells. Proliferating cells maintained in the presence of platelet-derived growth factor or basic fibroblast growth factor retained nestin expression along with A2B5. By contrast, in serum-free medium nestin expression decreased while postmitotic cells acquired A007 and galactocerebroside. Our results suggest that nestin expression is a marker of pre-O2A cells that is maintained in proliferating glial progenitors, but is quickly down-regulated in postmitotic oligodendrocytes (A007(+)/galacto-cerebroside(+)) along with A2B5 and vimentin. However, other glial cells including type 2 astrocytes and some amoeboid microglia also share nestin expression.
Complete Chloroplast Genome Sequence of Holoparasite Cistanche deserticola (Orobanchaceae) Reveals Gene Loss and Horizontal Gene Transfer from Its Host Haloxylon ammodendron (Chenopodiaceae) (2013)

The central function of chloroplasts is to carry out photosynthesis, and its gene content and structure are highly conserved across land plants. Parasitic plants, which have reduced photosynthetic ability, suffer gene losses from the chloroplast (cp) genome accompanied by the relaxation of selective constraints. Compared with the rapid rise in the number of cp genome sequences of photosynthetic organisms, there are limited data sets from parasitic plants. PRINCIPAL FINDINGS/SIGNIFICANCE: Here we report the complete sequence of the cp genome of Cistanche deserticola, a holoparasitic desert species belonging to the family Orobanchaceae. The cp genome of C. deserticola is greatly reduced both in size (102,657 bp) and in gene content, indicating that all genes required for photosynthesis suffer from gene loss and pseudogenization, except for psbM. The striking difference from other holoparasitic plants is that it retains almost a full set of tRNA genes, and it has lower dN/dS for most genes than another close holoparasitic plant, E. virginiana, suggesting that Cistanche deserticola has undergone fewer losses, either due to a reduced level of holoparasitism, or to a recent switch to this life history. We also found that the rpoC2 gene was present in two copies within C. deserticola. Its own copy has much shortened and turned out to be a pseudogene. Another copy, which was not located in its cp genome, was a homolog of the host plant, Haloxylon ammodendron (Chenopodiaceae), suggesting that it was acquired from its host via a horizontal gene transfer.
The role of HER2 overexpression in Middle Eastern papillary thyroid cancer (2017)

Background: HER2 oncogene is involved in many cancers and serves as a prognostic marker and therapeutic target in breast cancer. The purpose of this study was to learn more on the prevalence and clinical significance of HER2 overexpression and its association with clinical parameters in Middle Eastern papillary thyroid carcinoma (PTC). Methods: A tissue microarray (TMA) containing >1,000 PTC cases with follow-up data was used. TMA sections were analyzed on protein and DNA level using immunohistochemistry and fluorescence in situ hybridization (FISH). FISH analyses were performed to look for the gain or amplifications in HER2 gene. Results: Immunohistochemical analysis showed HER2 overexpression in 19.7% of our cases. Elevated expression was almost exclusively 2+ (194 tumors) and only rarely 3+ (1 tumor). No amplification was seen by FISH. Only 3% of our cases showed mildly elevated HER2 gene copy numbers not reaching the threshold for amplification. HER2 overexpression and copy number gains were unrelated to tumor stage, metastasis, patient survival and other clinical and pathological parameters. Conclusions: Our results demonstrated that HER2 overexpression occurs at relevant frequency in papillary thyroid cancer and in the absence of gene amplification. Additionally, expression of HER2 seems to hold no clinical value as prognostic factor in PTC.
Chikungunya Virus Vaccine Prepared by Tween-Ether Extraction (1970)

Chikungunya virus vaccines prepared by Tween 80 and ether inactivation of virus grown in green monkey kidney cell cultures were shown to be as immunogenic as comparable Formalin-inactivated vaccines. Both types of vaccine stimulated hemagglutination-inhibiting, complement-fixing, and neutralizing antibody and afforded protection to mice against a live virus challenge. It was shown after Tween-ether treatment of chikungunya virus that the infectivity of the virus was lost and the hemagglutinin titer was increased. By characterization of the resultant hemagglutinin by sucrose and cesium chloride density gradient centrifugation, it was found that the extracted particle was smaller in size and greater in density than the parent virus particle. Removal of lipid may account for the alterations in the physical characteristics of the infectious virus particle. Conditions for treatment of chikungunya virus with Tween and ether were found that preserved high titers of hemagglutinin as well as the immunogenicity of the virus preparations.
Molecular Imaging of In Vivo Gene Expression (2010)

Molecular imaging provides spatial and temporal information on cellular changes that occur during development and in disease. MRI and optical imaging of reporter genes allows for the visualization of promoter activity, protein–protein interactions, protein stability and the tracking of individual proteins and cells. Reporter genes can be genetically encoded in transgenic animals or detected through the administration of an exogenous contrast agent. Advances in molecular imaging of reporter genes have led to the development of imaging probes that detect changes in endogenous cellular changes. The ability to use contrast agents coupled with functional information on cellular events will allow for sensitive assessment of individual patient therapies, leading to an accurately tailored treatment regimen.
Kinetic Differences in Unresponsiveness of Thymus and Bone Marrow Cells (1971)

Both thymus and bone marrow cells of adult mice can be made specifically unresponsive to human gamma globulin, but each cell population displays a distinct kinetic pattern for both the induction and spontaneous loss of the unresponsive state. These kinetics appear to be much slower in the bone marrow cells than in the thymus cells. In addition, the dose of deaggregated human gamma globulin needed to induce unresponsiveness in bone marrow cells is much greater than that needed to induce unresponsiveness in thymus cells. Apparently, unresponsiveness in only one cell type is sufficient for the tolerant state to be exhibited by the intact animal.
Dynamic Behaviour of the first instrumented building in France: The Grenoble Town Hall (2007)

The French Accelerometric Network (RAP) launched in November 2004 a marked operation for the seismic behaviour assessment of a typical French building. The main goal of this project is to collect accelerometric data in the building and use them to calibrate models or alternative tools used for the seismic behaviour assessment. The final goal of this project is to help the vulnerability assessment of cities in moderate seismic hazard countries. The French Accelerometric Network (RAP) chose to install a permanent network of 6 accelerometers recording continuously the vibrations of the Grenoble City Hall at the basement and at the top. The 13-story building is a RC shear walls building, typical of the RC structures designed at the end of the 60's in France. All the data collected in the building are available on the online access database of the RAP. In addition to the permanent network, an ambient vibration experiment has been performed in 36 points of the whole building. Using the Frequency Domain Decomposition method, these data allowed estimating precisely the different modes of vibration of the structure for low amplitudes. Only the first bending modes in each direction (1.15 and 1.22 Hz) and the first torsion mode (1.44 Hz) are excited. We compared the frequencies obtained using ambient vibration to those for a moderate earthquake recorded by the permanent network. Thanks to the continuous recording, a statistical approach of the torsion mode pointed out the position of the centre of rotation of the building. A modal model extracted from ambient vibrations is proposed and validated thanks to the earthquake recordings collected in the building during the ML=4.6, September 8th 2005 Vallorcine (Haute-Savoie, France) earthquake.
ChemInform Abstract: RK. VON B‐METHOXY‐DIALKYLBORANEN MIT LI‐AL‐HYDRID IN GEGENWART VON OLEFINEN, SYNTH. VON GEMISCHTEN ACYCLISCHEN UND CYCLISCHEN TRIALKYLBORANEN UND UMWANDLUNG IN TRIALKYLCARBINOLE (1971)

Abstract Die Borane (I) werden mit LiAlH 4 in Gegenwart der Olefine (II) zu den Trialkylboranen (III) (80‐90% Ausbeute) reduziert, die nach Zugabe von Äthylenglykol bei 150°C zu den Dioxaborolanen (IV) carbonyliert und anschließend zu den Carbinolen (V) (75‐95 %) oxidiert werden.