gebhart/patrepeval huggingface dataset:
Dependence of gradient‐echo and spin‐echo BOLD fMRI at 4 T on diffusion weighting (2006)

Diffusion weighting and spin-echo (SE) acquisitions can be used to help improve the spatial localization of BOLD fMRI at the cost of reduced acquisition rates and lower signal-to-noise ratio (SNR). To evaluate these costs, SE and gradient-echo (GE) data were acquired at 4 T at five diffusion weightings ranging from b = 0 to 1110 s/mm(2) using a robust visual stimulus. The data showed reduced functional contrast when diffusion weighting was applied. As the amount of diffusion weighting increased, the functional contrast initially dropped sharply, and then remained relatively constant for diffusion weightings above 15 s/mm(2) for SE and 30 s/mm(2) for GE data. GE functional BOLD contrast was attenuated to 94.0 +/- 10.1, 87.6 +/- 12.2, 86.4 +/- 8.8 and 83.3 +/- 20.6% of the non-diffusion-weighted GE contrast for diffusion weightings of 15, 30, 200 and 1,110 s/mm(2). The non-diffusion-weighted SE contrast greatly reduced to 19.3 +/- 3.3% of the non-diffusion-weighted GE contrast, demonstrating the large activation attenuation of a SE acquisition. The SE contrast was further reduced to 10.0 +/- 3.6, 9.0 +/- 2.5 and 8.6 +/- 2.0% of the non-diffusion-weighted GE contrast for the 15, 30 and 200 s/mm(2) diffusion-weighted data. These results suggest that only a small amount of diffusion weighting is necessary to suppress the vascular contribution and spin-echo imaging should only be used if there is adequate statistical power available or accurate localization is critical.
Abstract 3385: Liquid biopsy to detect MET exon 14 skipping (METex14) and MET amplification in patients with advanced NSCLC: Biomarker analysis from VISION study (2020)

Abstract Purpose: In the ongoing, single-arm, Phase 2 VISION study (NCT02864992), tepotinib (a highly selective MET inhibitor) has shown durable clinical activity in NSCLC patients (pts) with METex14 skipping. Here, we report the biomarker profile of pts screened with liquid biopsy (LBx) for inclusion in the study. Methods: Pts with advanced NSCLC and previously confirmed EGFR/ALK wild-type status were prospectively screened for MET alterations using plasma samples collected during pre-screening/screening. Plasma ctDNA sequencing was performed at a central laboratory using a 73-gene next-generation sequencing panel (Guardant360®). Results: Of 6,034 pts screened, 813 pts had results pending at data cut and of 5,221 pts tested, sequencing failed in 41 pts. The success rate of LBx testing was consistent across centers. Of 5,180 patients analyzed, 694 pts (13.4%) had no mutation detected. Despite the intent of screening EGFR/ALK wild-type pts, 327 pts (6.3%) had EGFR mutations and 49 (0.9%) had ALK/ROS fusions. 188 pts (3.6%) had METex14 skipping (Table) and 256 pts (4.9%) had MET amplification (amp) without METex14 skipping. The median age of METex14 pts was 72 years; 47% were male; 46% were never smokers and 65% had adenocarcinoma histology. In METex14 pts, the most frequently occurring driver co-alterations were amp in MET (13.3%), EGFR (7.4%), CDK4 (6.4%), BRAF (5.3%) and CDK6 (4.8%), and mutations in GNAS (5.3%). In METamp pts, the most frequently occurring driver co-alterations were CDK6 (60.5%), BRAF (43.4%), EGFR (28.9%), MYC (21.9%) and CCNE1 (19.9%) amps. Overall, TP53 mutations were detected in 55.9% of METex14 pts and 79.7% of METamp pts. Table:Characterization of METex14 skipping (n=188)n (%)Insertions/deletions (indels)93 (49.5)Indel at acceptor site54 (28.7)Indel at donor site36 (19.1)Whole exon 14 deletion3 (1.6)Single nucleotide variation (SNV)95 (50.5)SNV at donor site93 (49.5)SNV at acceptor site2 (1.1)SNVs and indelsSNV/indel at donor site129 (68.6)SNV/indel at acceptor site56 (29.8)SNV/indel whole exon 14 deletion3 (1.6) Conclusions: In this population, METex14 skipping can be successfully detected through non-invasive LBx analysis using a next-generation sequencing panel. The rate of METex14 skipping and the genomic profile and demographics of pts were similar to previously reported data. Citation Format: Xiuning Le, Dariusz Kowalski, Byoung Chul Cho, Pierfranco Conte, Enriqueta Felip, Marina Chiara Garassino, Santiago Viteri, Gee-Chen Chang, John Richart, Luiz Paz-Ares, Dilafruz Juraeva, Josef Straub, Christopher Stroh, Paul Paik. Liquid biopsy to detect MET exon 14 skipping (METex14) and MET amplification in patients with advanced NSCLC: Biomarker analysis from VISION study [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 3385.
Test for Selenium Based on Catalytic Effect (1947)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTest for Selenium Based on Catalytic EffectFritz. Feigl and P. W. WestCite this: Anal. Chem. 1947, 19, 5, 351–353Publication Date (Print):May 21, 1947Publication History Published online1 May 2002Published inissue 21 May 1947https://pubs.acs.org/doi/10.1021/ac60005a025https://doi.org/10.1021/ac60005a025research-articleACS PublicationsRequest reuse permissionsArticle Views153Altmetric-Citations44LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Monitoring of Extracellular Aspartate Aminotransferase and Troponin T by Microdialysis during and after Cardioplegic Heart Arrest (1999)

This study aims at developing per- and postopertive surveillance of the myocardium and focuses on ischemic damage following cardioplegic heart arrest. Levels of troponin T and total aspartate aminotransferase (ASAT) were analyzed in the myocardial interstitium of 10 patients with ischemic heart disease (IHD) who underwent coronary bypass surgery and in 12 patients with nonischemic heart disease (N-IHD) who underwent valvular surgery. Fluid from the myocardial interstitium of the anterior and the lateral wall of the heart was sampled by microdialysis probes that were implanted during surgery and extracted percutaneously 70-100 h later. There were no adverse reactions, and the equipment did not interfere with the surgical procedures. The peak in troponin T serum levels that occurred 4 h after cardiac arrest was preceded by a peak in troponin T levels in the microdialysates from the interstitium that occurred 1 h earlier. The concentration of troponin T in the microdialysate peak was 300 times higher than in the serum peak. The increase in serum ASAT levels during the first 7 h after cardiac arrest corresponded in time with a decrease in interstitial ASAT levels, which had already reached a maximum during cardiac arrest. The microdialysate/serum concentration ratio was considerably smaller for ASAT than for troponin T. Interstitial peak levels of troponin T correlated positively and significantly with peak levels of ASAT. Of the 22 patients, 15 had no postoperative events according to clinical outcome, ECG and serum tests. Fourteen of these had low to normal levels of interstitial ASAT and troponin T. Conversely, atrial fibrillation and/or premature atrial contractions were recorded in 8/22 patients, 7 of whom had elevated interstitial ASAT and/or troponin T concentrations in one or both of the sampled heart regions. The N-IHD patients had higher levels of troponin T in the interstitium 20-70 h following cardioplegia, while the peak levels did not differ between the groups. In conclusion, microdialysis sampling of troponin T and ASAT is safe and allows a highly sensitive analysis of the ischemic trauma exerted by the cardioplegic arrest.
An early history of human breast cancer: West meets East (2013)

Cancer has been increasingly recognized as a global issue. This is especially true in countries like China, where cancer incidence has increased likely because of changes in environment and lifestyle. However, cancer is not a modern disease; early cases have been recorded in ancient medical books in the West and in China. Here, we provide a brief history of cancer, focusing on cancer of the breast, and review the etymology of ai, the Chinese character for cancer. Notable findings from both Western and Chinese traditional medicine are presented to give an overview of the most important, early contributors to our evolving understanding of human breast cancer. We also discuss the earliest historical documents to record patients with breast cancer.
N-Doped Carbon Dot Hydrogels from Brewing Waste for Photocatalytic Wastewater Treatment (2022)

The brewery industry annually produces huge amounts of byproducts that represent an underutilized, yet valuable, source of biobased compounds. In this contribution, the two major beer wastes, that is, spent grains and spent yeasts, have been transformed into carbon dots (CDs) by a simple, scalable, and ecofriendly hydrothermal approach. The prepared CDs have been characterized from the chemical, morphological, and optical points of view, highlighting a high level of N-doping, because of the chemical composition of the starting material rich in proteins, photoluminescence emission centered at 420 nm, and lifetime in the range of 5.5-7.5 ns. With the aim of producing a reusable catalytic system for wastewater treatment, CDs have been entrapped into a polyvinyl alcohol matrix and tested for their dye removal ability. The results demonstrate that methylene blue can be efficiently adsorbed from water solutions into the composite hydrogel and subsequently fully degraded by UV irradiation.
ChemInform Abstract: 1‐(Fluorobenzyl)‐4‐amino‐1H‐1,2,3‐triazolo(4,5‐c)pyridines: Synthesis and Anticonvulsant Activity. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Electromechanical Analysis of a Piezoelectric Instrumented Composite Bonded Repair Patch (2020)

The scope of this study is to investigate the feasibility of using piezoelectric sensing technology for assessing the structural integrity of a bonded patch, using an experimental and numerical approach. Numerical analyses, involving the application of finite element methodology, are presented in this paper. The goal of these numerical studies is to reduce the number of required experiments and to investigate the applicability of finite element methodology in evaluating the electromechanical response of composite bonded repair patches with embedded or surface bonded piezoelectric film sensors. The SMARTCOM finite element approach developed by Koko et. al. [1] is used for this investigation. The numerical results obtained provide insight into the electromechanical behaviour of instrumented composite bonded repair patches. Based on these results, limitations of the methodology and recommendations for effective modeling approaches for composite patches with piezoelectric sensors are presented and discussed.
Both Calmodulin and the Unconventional Myosin Myr4 Regulate Membrane Trafficking Along the Recycling Pathway of MDCK Cells (2000)

In epithelial cells, endocytosed transferrin and its receptor, which cycle basolaterally, have been shown to transit through recycling endosomes which can also be accessed by markers internalized from the apical surface. In this work, we have used an in vitro assay to follow transfer of an endocytosed marker from apical or basolateral early endosomes to recycling endosomes labeled with transferrin. We show that calmodulin (CaM) function is necessary for transfer and identified myr4, a member of the unconventional myosin superfamily known to use CaM as a light chain, as a possible target protein for CaM. Since myr4 is believed to act as an actin-based mechanoenzyme, we tested the role of polymerized actin in the assay. Our data show that conditions which either prevent actin polymerization or induce the breakdown of existing filaments strongly inhibit interactions between recycling endosomes and either set of early endosomes. Altogether, our data indicate that trafficking at early steps of the endocytic pathway in Madin-Darby Canine Kidney cells depends on the actin-based mechanoenzyme myr4, its light chain CaM, and polymerized actin.
Charge distribution uncertainty in differential mobility analysis of aerosols (2017)

The inference of particle size distributions from differential mobility analyzer (DMA) data requires knowledge of the charge distribution on the particles being measured. The charge distribution produced by a bipolar aerosol charger depends on the properties of the ions produced in the charger, and on the kinetics of charge transfer from molecular ions or ion clusters to the particles. A single parameterization of a theoretically predicted charge distribution is employed in most DMA analyses regardless of the atmospheric conditions being probed. Deviations of the actual charge distribution from that assumed in the data analysis will bias the estimated particle size distribution. We examine these potential biases by modeling measurements and data inversion using charge distributions calculated for a range of atmospheric conditions. Moreover, simulations were performed using the ion-to-particle flux coefficients predicted for a range of properties of both the particles and ions. To probe the biases over the full range of particle sizes, the measurements were simulated through an atmospheric new particle formation event. The differences between the actual charge distribution and that according to the commonly used parametrization resulted in biases as large as a factor of 5 for nucleation-mode particles, and up to 80% for larger particles. Incorrect estimates of the relative permittivity of the particles or not accounting for the temperature and pressure effects for measurements at 10 km altitude produced biases in excess of 50%; three-fold biases result from erroneous estimates of the ion mobility distribution. We further report on the effects of the relative permittivity of the ions, the relative concentrations of negative and positive ions, and truncation of the number of charge states considered in the inversion. Copyright © 2017 American Association for Aerosol Research
Auction theory (1987)

Auctions are one of the oldest surviving classes of economic institutions. The first historical record of an auction is usually attributed to Herodotus, who reported a custom in Babylonia in which men bid for women to wed. Other observers have reported auctions throughout the ancient world - in Babylonia, Greece, the Roman Empire, China, and Japan.
Partial antagonism between steroidal and nonsteroidal antiestrogens in human breast cancer cell lines. (1998)

Nonsteroidal antiestrogens, such as tamoxifen, are well established in the treatment of breast cancer. The development of new steroidal compounds without partial agonist activity allows deeper insights into the mechanism of antiestrogen action, but thus far, the combined use of steroidal and nonsteroidal antiestrogens has not been studied extensively. We compared the nonsteroidal 4-trans-hydroxytamoxifen (OHT) with the two steroidal antiestrogens, ICI 182780 and RU 58668, in the estrogen receptor-positive human breast cancer cell lines MCF-7 and T47D. The effect of each compound alone or of OHT in combination with one of the steroidal antiestrogens was studied in regard to cell proliferation, expression of estrogen receptors (ERs) and progesterone receptors, and secretion of transforming growth factor beta2 (TGF-beta2). All antiestrogens examined led to enhanced secretion of TGF-beta2, which is correlated with their individual growth-inhibitory potential. OHT partially counteracts the larger growth inhibition of human breast cancer cells exerted by the steroidal antiestrogens ICI 182780 and RU 58668. Also, OHT antagonizes the higher induction of TGF-beta2 seen after treatment of MCF-7 cells with steroidal antiestrogens. The loss of ER and down-regulation of progesterone receptor under treatment with the steroidal antiestrogens is prevented by OHT, whereas the steroidal antiestrogens prevent the ability of hydroxytamoxifen to increase the ER content. These results indicate that TGF-beta2 is a marker of action for both types of compounds, but steroidal and nonsteroidal antiestrogens partially antagonize each other in blocking ER-mediated cellular events. It would appear that no additive or synergistic effect of the two types of antiestrogens can be expected in the treatment of breast cancer.
IDDF2019-ABS-0028 Mucosal tissue short chain fatty acids contribute to prediction of pouchitis in restorative proctocolectomy (2019)

<h3>Background</h3> Restorative proctocolectomy is a surgical option in patients with ulcerative colitis who become refractory to medical therapy. Various studies have implicated SCFA in both the development of IBD and flares of IBD. Furthermore, it has been shown that SCFA concentrations are significantly lower in faecal samples from patients with pouchitis when compared with healthy controls. Our study aimed to assess longitudinal changes in SCFA that occur in a pouch to determine if they can predict or are associated with the development of pouchitis. To date no study has analysed short chain fatty acids in mucosal biopsy tissue from these patients. <h3>Methods</h3> Patients who underwent restorative proctocolectomy at a single centre underwent pouchoscopy at the time of restoration of continuity and then every 6 months for a year. Biopsies were retrieved from the pouch body. Pouchitis was defined using the pouch disease activity index. The development of pouchitis was assessed at 6 and 12 months.SCFA were measured using an Agilent 7000C Triple Quadrupole GC/MS-MS System. Simca was used for multivariate analysis and T-tests were used for univariate analysis. <h3>Results</h3> There were 56 biopsy samples. There were 22 patients (17 males); 16 UC and 6 FAP patients. Median age of the cohort was 40 years (range 20–60 years). Of the UC patients four developed pouchitis within one year. Comparing UC patients at the time of closure of ileostomy, there were significant decreases in caproic acid (4674uM vs 12217uM p&lt;0.01), valeric acid (1580uM vs 3695uM p=0.01), isovolaric acid (721uM vs 2940uM p=0.05), isobutyric acid 35072uM vs 76074uM p=0.03) and lactic acid (1580uM vs 3732uM p=0.02) between those who developed pouchitis within a year and those who did not develop pouchitis at 1 year. <h3>Conclusions</h3> A decrease in SCFA found in the mucosal tissue at time of closure of ileostomy may predict onset of pouchitis within a year. This study is the first to demonstrate that SCFA can be analysed from biopsies. Future studies need to determine factors that may contribute to tissue SCFA levels which may help reduce the incidence of pouchitis.
Prediction-Based Power Oversubscription in Cloud Platforms (2020)

Datacenter designers rely on conservative estimates of IT equipment power draw to provision resources. This leaves resources underutilized and requires more datacenters to be built. Prior work has used power capping to shave the rare power peaks and add more servers to the datacenter, thereby oversubscribing its resources and lowering capital costs. This works well when the workloads and their server placements are known. Unfortunately, these factors are unknown in public clouds, forcing providers to limit the oversubscription so that performance is never impacted. In this paper, we argue that providers can use predictions of workload performance criticality and virtual machine (VM) resource utilization to increase oversubscription. This poses many challenges, such as identifying the performance-critical workloads from black-box VMs, creating support for criticality-aware power management, and increasing oversubscription while limiting the impact of capping. We address these challenges for the hardware and software infrastructures of Microsoft Azure. The results show that we enable a 2x increase in oversubscription with minimum impact to critical workloads.
Measurement of resistive wall mode stability in rotating high-β DIII-D plasmas (2005)

Toroidal plasma rotation of the order of a few per cent of the Alfvén velocity can stabilize the resistive wall mode (RWM) and extend the operating regime of tokamaks from the conventional, ideal magnetohydrodynamic (MHD) no-wall limit up to the ideal MHD ideal-wall limit. The stabilizing effect has been measured in DIII-D passively by measuring the critical plasma rotation required for stability and actively by probing the plasma with externally applied resonant magnetic fields. The comparison of these measurements to predictions of rotational stabilization of the sound wave damping and of the kinetic damping model using the MARS-F code results in qualitative agreement, but also indicates the need for further refinement of the measurements and models.
Factors determining the development of algal and bacterial blooms in the Dead Sea: a study of simulation experiments in outdoor ponds (1985)

To simulate the occurrence of bacterial and algal blooms in the Dead Sea, we filled 5.6 m3 outdoor ponds with mixtures of Dead Sea water and Mediterranean water, at different seasons, and studied the effect of salinity and of addition of glycerol, glucose and different concentrations of phosphate on the rate and extent of bacterial and algal growth. Addition of phosphate appeared to be essential for the development of mass blooms of both the green alga Dunaliella and of the red halobacteria. In the presence of phosphate the growth rates were high only when the Dead Sea water was diluted by at least 25–35% with Mediterranean water. Also, at low temperatures (14–17°C) mass blooms of bacteria and algae occurred, but growth rates were reduced, and the maximal salinity at which growth was observed shifted to a lower value. Glucose, glycerol and a Dunaliella bloom all proved to be suitable carbon sources for mass development of halobacteria.