gebhart/patrepeval huggingface dataset:
Cassini observations of ionospheric plasma in Saturn's magnetotail lobes (2015)

Studies of Saturn's magnetosphere with the Cassini mission have established the importance of Enceladus as the dominant mass source for Saturn's magnetosphere. It is well known that the ionosphere is an important mass source at Earth during periods of intense geomagnetic activity, but lesser attention has been dedicated to study the ionospheric mass source at Saturn. In this paper we describe a case study of data from Saturn's magnetotail, when Cassini was located at ≃ 2200 h Saturn local time at 36 <i>R</i><sub><i>S</i></sub> from Saturn. During several entries into the magnetotail lobe, tailward flowing cold electrons and a cold ion beam were observed directly adjacent to the plasma sheet and extending deeper into the lobe. The electrons and ions appear to be dispersed, dropping to lower energies with time. The composition of both the plasma sheet and lobe ions show very low fluxes (sometimes zero within measurement error) of water group ions. The magnetic field has a swept-forward configuration which is atypical for this region, and the total magnetic field strength is larger than expected at this distance from the planet. Ultraviolet auroral observations show a dawn brightening, and upstream heliospheric models suggest that the magnetosphere is being compressed by a region of high solar wind ram pressure. We interpret this event as the observation of ionospheric outflow in Saturn's magnetotail. We estimate a number flux between (2.95 ± 0.43) × 10<sup>9</sup> and (1.43 ± 0.21) × 10<sup>10</sup> cm<sup>-2</sup> s<sup>-1</sup>, 1 or about 2 orders of magnitude larger than suggested by steady state MHD models, with a mass source between 1.4 ×10<sup>2</sup> and 1.1 ×10<sup>3</sup> kg/s. After considering several configurations for the active atmospheric regions, we consider as most probable the main auroral oval, with associated mass source between 49.7 ±13.4 and 239.8 ±64.8 kg/s for an average auroral oval, and 10 ±4 and 49 ±23 kg/s for the specific auroral oval morphology found during this event. It is not clear how much of this mass is trapped within the magnetosphere and how much is lost to the solar wind.
Knockdown of formin mDia2 alters lamin B1 levels and increases osteogenesis in stem cells (2019)

Nuclear actin plays a critical role in mediating mesenchymal stem cell (MSC) fate commitment. In marrow-derived MSCs, the principal diaphanous-related formin Diaph3 (mDia2) is present in the nucleus and regulates intranuclear actin polymerization, whereas Diaph1 (mDia1) is localized to the cytoplasm and controls cytoplasmic actin polymerization. We here show that mDia2 can be used as a tool to query actin-lamin nucleoskeletal structure. Silencing mDia2 affected the nucleoskeletal lamin scaffold, altering nuclear morphology without affecting cytoplasmic actin cytoskeleton, and promoted MSC differentiation. Attempting to target intranuclear actin polymerization by silencing mDia2 led to a profound loss in lamin B1 nuclear envelope structure and integrity, increased nuclear height, and reduced nuclear stiffness without compensatory changes in other actin nucleation factors. Loss of mDia2 with the associated loss in lamin B1 promoted Runx2 transcription and robust osteogenic differentiation and suppressed adipogenic differentiation. Hence, mDia2 is a potent tool to query intranuclear actin-lamin nucleoskeletal structure, and its presence serves to retain multipotent stromal cells in an undifferentiated state.
SONIC NDE OF BRIDGES AND OTHER CONCRETE STRUCTURES (1992)

This paper presents recent innovations for sonic and ultrasonic scanning of concrete bridges and structures. Recent technical advances in instrumentation systems by the author's firm allow, for the first time, the potential for rapid scanning of structural concrete with ultrasonic and sonic methods. This recently developed instrumentation provides for practically continuous nondestructive testing with PC-based data acquisition and software analysis. Test data are presented to illustrate the applications of the scanner to traditional point-by-point Ultrasonic Pulse Velocity and Impact Echo methods. The paper also presents an introduction to a technology recently applied to nondestructive evaluation of concrete structures, especially slabs, tunnels, massive concrete structures, and other installations where information on thick concrete or on concrete and the subsurface behind the concrete is required. The technology, Spectral Analysis of Surface Waves, allows nondestructive determination of the shear wave velocities of the various components of a layered system while testing from only one surface. Included is an overview of the method and the principles behind it, as well as some case-history examples.
Novel clues on abiotic stress tolerance emerge from embryo proteome analyses of rice varieties with contrasting stress adaptation (2011)

Cereal embryos sustain severe water deficit at the final stage of seed maturation. The molecular mechanisms underlying the acquisition of desiccation tolerance in seed embryos are similar to those displayed during water deficit in vegetative tissues. The genetic variation among six rice genotypes adapted to diverse environmental conditions was analysed at the proteome level to get further clues on the mechanisms leading to water-stress tolerance. MS analysis allowed the identification of 28 proteins involved in stress tolerance (late embryogenesis abundant proteins), nutrient reservoir activity, among other proteins implicated in diverse cellular processes potentially related to the stress response (e.g., mitochondrial import translocase). Hierarchical clustering and multidimensional scaling analyses revealed a close relationship between the stress-sensitive genotypes, whereas the stress-tolerant varieties were more distantly related. Besides qualitative and significant quantitative changes in embryo proteins across the distinct varieties, we also found differences at post-translational level. The results indicated that late embryogenesis abundant Rab21 was more strongly phosphorylated in the embryos of the sensitive varieties than in the embryos of the tolerant ones. We propose that the differences found in the phosphorylation status of Rab21 are related to stress tolerance.
Measurement of calcium transients and slow calcium current in myotubes. (1994)

The purpose of this study was to characterize excitation-contraction (e-c) coupling in myotubes for comparison with e-c coupling of adult skeletal muscle. The whole cell configuration of the patch clamp technique was used in conjunction with the calcium indicator dye Fluo-3 to study the calcium transients and slow calcium currents elicited by voltage clamp pulses in cultured myotubes obtained from neonatal mice. Cells were held at -80 mV and stimulated with 15-20 ms test depolarizations preceded and followed by voltage steps designed to isolate the slow calcium current. The slow calcium current had a threshold for activation of about 0 mV; the peak amplitude of the current reached a maximum at 30 to 40 mV a and then declined for still stronger depolarizations. The calcium transient had a threshold of about -10 mV, and its amplitude increased as a sigmoidal function of test potential and did not decrease again even for test depolarizations sufficiently strong (> or = 50 mV) that the amplitude of the slow calcium current became very small. Thus, the slow calcium current in myotubes appears to have a negligible role in the process of depolarization-induced release of intracellular calcium and this process in myotubes is essentially like that in adult skeletal muscle. After repolarization, however, the decay of the calcium transient in myotubes was very slow (hundreds of ms) compared to adult muscle, particularly after strong depolarizations that triggered larger calcium transients. Moreover, when cells were repolarized after strong depolarizations, the transient typically continued to increase slowly for up to several tens of ms before the onset of decay. This continued increase after repolarization was abolished by the addition of 5 mM BAPTA to the patch pipette although the rapid depolarization-induced release was not, suggesting that the slow increase might be a regenerative response triggered by the depolarization-induced release of calcium. The addition of either 0.5 mM Cd2+ + 0.1 mM La3+ or the dihydropyridine (+)-PN 200-110 (1 microM) reduced the amplitude of the calcium transient by mechanisms that appeared to be unrelated to the block of current that these agents produce. In the majority of cells, the decay of the transient was accelerated by the addition of the heavy metals or the dihydropyridine, consistent with the idea that the removal system becomes saturated for large calcium releases and becomes more efficient when the size of the release is reduced.
Load-Following Voltage Controller Design for a Static Space Nuclear Power System (2000)

The reliability of static space nuclear power systems (SNPSs) could be improved through the use of backup devices in addition to shunt regulators, as currently proposed for load following. Shunt regulator failure leading to reactor shutdown is possible, as is the possible need to deliver somewhat higher power level to the load than originally expected. A backup system is proposed in SNPSs to eliminate the possibility of a single-point failure in the shunt regulators and to increase the overall system power delivery capability despite changing mission needs and component characteristics. The objective of this paper is to demonstrate the feasibility of such a backup device for voltage regulation in static SNPSs that is capable of overcoming system variations resulting from operation at different power levels. A dynamic compensator is designed using the Linear Quadratic Gaussian with Loop Transfer Recovery method. The resulting compensators are gain scheduled using the SNPS electric power as the scheduling variable, resulting in a nonlinear compensator. The performance of the gain-scheduled compensator is investigated extensively using an SNPS simulator. The simulations demonstrate the effects of the fuel temperature reactivity coefficient variations on the load-following capabilities of the SNPS. Robustness analysis results demonstrate that the proposed controller exhibits significant operational flexibility, and it can be considered for long-term space mission requiring significant levels of autonomy.
Single-use phosphorimetric sensor for the determination of nalidixic acid in human urine and milk (2000)

A single-use phosphorimetric sensor to determine the germicide nalidixic acid is proposed. The sensing action is based on the absorption of the analyte into the sensing zone and the subsequent measurement of the phosphorescence intensity emitted by the analyte fixed in the sensor. This plane drop sensor is made up of a 3 x 1.6 cm sheet of the polyester Mylar as solid support, and a circular film 5 mm in diameter and 20 microns in thickness, formed by poly(vinyl chloride) and tributyl phosphate as the plasticizer, adhered to its surface. The sensor is introduced for 2 h into the sample solution, after which it is dried and the phosphorescence intensity is measured directly at lambda ex = 332 nm, lambda em = 412 nm, with a delay time of 0.15 ms and a gate time of 10 ms, under a dry nitrogen stream. The characteristic parameters of the construction of the sensing zone and of the processes of fixing the analyte along with the emission of phosphorescence were studied. The applicable concentration range was from 60 to 1500 ng ml-1, with a detection limit of 20 ng ml-1 and a precision of 2% expressed as relative standard deviation. The method was applied to the determination of nalidixic acid in milk and human urine with recoveries ranging between 96.0 and 103.7%. The calibration process was carried out by applying a mathematical method of finite elements that expresses the analytical signal as a function of the analyte concentration and equilibration time between the sensor and the sample solution.
&omega;3 Fatty Acids Effectively Prevent Coronary Heart Disease and Other Late-Onset Diseases – The Excessive Linoleic Acid Syndrome (2006)

Research Articles| January 26 2009 Démonstrations cliniques d'une série d'affections de l'oesophage Subject Area: Gastroenterology M. Michaud M. Michaud Lausanne Search for other works by this author on: This Site PubMed Google Scholar Gastroenterologia (1939) 64 (5-6): 263–267. https://doi.org/10.1159/000197809 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation M. Michaud; Démonstrations cliniques d'une série d'affections de l'oesophage. Gastroenterologia 31 December 1939; 64 (5-6): 263–267. https://doi.org/10.1159/000197809 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsGastroenterologia Search Advanced Search Article PDF first page preview Close Modal Journal Section: Paper This content is only available via PDF. Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 1939 You do not currently have access to this content.
Low-frequency noise in multilayer MoS2field-effect transistors: the effect of high-k passivation (2013)

Diagnosing of the interface quality and the interactions between insulators and semiconductors is significant to achieve the high performance of nanodevices. Herein, low-frequency noise (LFN) in mechanically exfoliated multilayer molybdenum disulfide (MoS2) (~11.3 nm-thick) field-effect transistors with back-gate control was characterized with and without an Al2O3 high-k passivation layer. The carrier number fluctuation (CNF) model associated with trapping/detrapping the charge carriers at the interface nicely described the noise behavior in the strong accumulation regime both with and without the Al2O3 passivation layer. The interface trap density at the MoS2-SiO2 interface was extracted from the LFN analysis, and estimated to be Nit ~ 10(10) eV(-1) cm(-2) without and with the passivation layer. This suggested that the accumulation channel induced by the back-gate was not significantly influenced by the passivation layer. The Hooge mobility fluctuation (HMF) model implying the bulk conduction was found to describe the drain current fluctuations in the subthreshold regime, which is rarely observed in other nanodevices, attributed to those extremely thin channel sizes. In the case of the thick-MoS2 (~40 nm-thick) without the passivation, the HMF model was clearly observed all over the operation regime, ensuring the existence of the bulk conduction in multilayer MoS2. With the Al2O3 passivation layer, the change in the noise behavior was explained from the point of formation of the additional top channel in the MoS2 because of the fixed charges in the Al2O3. The interface trap density from the additional CNF model was Nit = 1.8 × 10(12) eV(-1) cm(-2) at the MoS2-Al2O3 interface.
Temperature sensitive microgel suspensions: Colloidal phase behavior and rheology of soft spheres (1999)

Rheological properties and the equilibrium colloidal phase behavior of concentrated dispersions of a temperature sensitive microgel were investigated. The temperature sensitive hydrogel particles consist of poly (N-isopropylacrylamid) (PNiPAM) chemically crosslinked with N,N′ methylenbisacrylamid (BIS). With increasing temperature the microgel particles decrease in size (hydrodynamic radius 142 nm at 10 °C and 58 nm at 35 °C) and with it the effective volume fraction, which leads to dramatic changes in rheology—vanishing yield stress and decreasing viscosity and elastic properties. The relative zero-shear viscosity and the plateau modulus at different temperatures superpose to mastercurves when plotted vs the effective volume fraction. The monodisperse hydrogel particles form colloidal crystals and glasses in concentrated solution but at higher effective volume fractions as compared to model hard sphere suspensions. Comparison of the experimental freezing point with soft sphere computer simulations indicate a repulsive interaction potential of the order 1/r12. The frequency independent shear modulus exhibited a power law concentration dependence which also agrees with the soft sphere behavior.
Grandparents as Guards: A Game Theoretic Analysis of Inheritance and Post Marital Residence in a World of Uncertain Paternity (2012)

I unify the following (1) men face paternity uncertainty while women do not face maternity uncertainty, (2) putative fathers and paternal kin care about true paternity, (3) paternity confidence is systematically lower in matrilocal cultures than in patrilocal ones, (4) inheritance tends to be patrilineal where paternity confidence is high and matrilineal where it is low, and (5) most societies with patrilineal inheritance were patrilocal while most societies with matrilineal inheritance were matrilocal. I explore the following related puzzles: (1) Why were patrilineal-patrilocal societies (PP) more sexually restrictive for women than matrilineal-matrilocal ones (MM)? (2) Why did the older generation in PP and MM societies play starkly different roles in sexual monitoring? (3) Why did most societies emerge as PP while a few became MM? (4) Can the correlation between inheritance and post-marital residence be explained without assuming the exogeneity of either? To answer these questions I look at the simultaneous determination of inheritance, residence, and levels of sexual monitoring/permissiveness.
The Structures of the C185S and C185A Mutants of Sulfite Oxidase Reveal Rearrangement of the Active Site (2010)

Sulfite oxidase (SO) catalyzes the physiologically critical conversion of sulfite to sulfate. Enzymatic activity is dependent on the presence of the metal molybdenum complexed with a pyranopterin-dithiolene cofactor termed molybdopterin. Comparison of the amino acid sequences of SOs from a variety of sources has identified a single conserved Cys residue essential for catalytic activity. The crystal structure of chicken liver sulfite oxidase indicated that this residue, Cys185 in chicken SO, coordinates the Mo atom in the active site. To improve our understanding of the role of this residue in the catalytic mechanism of sulfite oxidase, serine and alanine variants at position 185 of recombinant chicken SO were generated. Spectroscopic and kinetic studies indicate that neither variant is capable of sulfite oxidation. The crystal structure of the C185S variant was determined to 1.9 A resolution and to 2.4 A resolution in the presence of sulfite, and the C185A variant to 2.8 A resolution. The structures of the C185S and C185A variants revealed that neither the Ser or Ala side chains appeared to closely interact with the Mo atom and that a third oxo group replaced the usual cysteine sulfur ligand at the Mo center, confirming earlier extended X-ray absorption fine structure spectroscopy (EXAFS) work on the human C207S mutant. An unexpected result was that in the C185S variant, in the absence of sulfite, the active site residue Tyr322 became disordered as did the loop region flanking it. In the C185S variant crystallized in the presence of sulfite, the Tyr322 residue relocalized to the active site. The C185A variant structure also indicated the presence of a third oxygen ligand; however, Tyr322 remained in the active site. EXAFS studies of the Mo coordination environment indicate the Mo atom is in the oxidized Mo(VI) state in both the C185S and C185A variants of chicken SO and show the expected trioxodithiolene active site. Density functional theory calculations of the trioxo form of the cofactor reasonably reproducd the Mo horizontal lineO distances of the complex; however, the calculated Mo-S distances were slightly longer than either crystallographic or EXAFS measurements. Taken together, these results indicate that the active sites of the C185S and C185A variants are essentially catalytically inactive, the crystal structures of C185S and C185A variants contain a fully oxidized, trioxo form of the cofactor, and Tyr322 can undergo a conformational change that is relevant to the reaction mechanism. Additional DFT calculations demonstrated that such methods can reasonably reproduce the geometry and bond lengths of the active site.
An epidemic model for security and performance of wireless sensor networks (2019)

Inderscience is a global company, a dynamic leading independent journal publisher disseminates the latest research across the broad fields of science, engineering and technology; management, public and business administration; environment, ecological economics and sustainable development; computing, ICT and internet/web services, and related areas.
Rh-Catalyzed Asymmetric Cycloaddition of Imines and Isocyanates (2011)

The current work represents a novel synthesis of pyrimidinones from α,β-unsaturated imines and isocyanates using a rhodium/phosphoramidite catalyst system. The corresponding products can be obtained with good yields and high enantioselectivities.
Recombinant fusion protein linking factor VIIa with albumin (rVIIaFP): Tissue distribution in rats (2014)

The data suggest that the FVIIa moiety is directing rVIIa-FP's tissue distribution while the albumin moiety is responsible for the prolonged tissue retention. Importantly, rVIIa-FP is highly concentrated and retained over a long period in the growth plate of the knee joint-a vulnerable site in haemophilia patients. Overall, these improved tissue distribution characteristics of rVIIa-FP may enhance compliance and allow a more convenient dosing frequency.
Citizenship Lessons in Abstinence-Only Sexuality Education (2007)

Abstract We examine abstinence-only-until-marriage education as part of a broad effort to reassert the primacy of conventional (hetero) sexual norms. While all sexuality education offers students lessons in “good sexual citizenship,” abstinence-only-until-marriage education reserves the rights and responsibilities of membership and belonging for those who are willing or able to conform to expectations of heterosexual marriage and excludes those whose sexual lives are routinely cast as suspect and excessive by the prevailing rhetoric. We advocate policies and curricula that recognize the citizenship stakes in sexuality education's lessons and that foster inclusive models of membership and belonging.