gebhart/patrepeval huggingface dataset:
A System for the Separation of the Components of Human Blood: Quantitative Procedures for the Separation of the Protein Components of Human Plasma1a,b,c (1950)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA System for the Separation of the Components of Human Blood: Quantitative Procedures for the Separation of the Protein Components of Human Plasma1a,b,cE. J. Cohn, F. R. N. Gurd, D. M. Surgenor, B. A. Barnes, R. K. Brown, G. Derouaux, J. M. Gillespie, F. W. Kahnt, W. F. Lever, C. H. Liu, D. Mittelman, R. F. Mouton, K. Schmid, and E. UromaCite this: J. Am. Chem. Soc. 1950, 72, 1, 465–474Publication Date (Print):January 1, 1950Publication History Published online1 May 2002Published inissue 1 January 1950https://pubs.acs.org/doi/10.1021/ja01157a122https://doi.org/10.1021/ja01157a122research-articleACS PublicationsRequest reuse permissionsArticle Views1322Altmetric-Citations440LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The SOFCAL experiment (1998)

SOFCAL is a hybrid instrument with both active and passive chambers to measure the proton and helium cosmic ray spectra from 0.2–10 TeV. An emulsion/x-ray film chamber is situated between a Cerenkov counter and an imaging calorimeter. Scintillating fibers (Sci-Fi) measure the electromagnetic (EM) cascades that develop in the calorimeter and identity the trajectory. The emulsion/x-ray film data provide an in-flight calibration of the Sci-Fi calorimeter. The data reduction techniques will be discussed and interim results of the analysis from a balloon flight will be presented.
Vectored DSL: benefits and challenges for service providers (2013)

Service providers are facing a two-dimensional challenge in deploying broadband access networks: the evolution of service demand and competition. The demand for content-rich services including high-definition multicast and unicast video is increasing. Also, telephone companies are facing fierce competition from cable companies, especially in the North American market. In areas where fiber to the home is not cost effective, vectored DSL is a cost-effective solution for achieving downstream data rates of 100 Mb/s over 500 m by leveraging the existing copper infrastructure. This article outlines the key market driving forces behind the need for high-speed DSL and specifically vectored DSL. This article also describes many vectoring features and capabilities, and highlights the key considerations for service providers in terms of vectored DSL planning, operation, and management.
Doppler ultrasonography with perfusion software and contrast agent injection as a tool for early evaluation of metastatic renal cancers treated with the Raf kinase and VEGFR inhibitor: A prospective study (2005)

3069 Background: BAY 43–9006 (BAY) is a novel Raf kinase and VEGFR inhibitor currently under investigation in phase III trials for the treatment of metastatic renal cancer (MRCC). BAY appears to have strong anti-angiogenic activity. The objective of this study is to evaluate Doppler Ultrasonography with perfusion software (Vascular Recognition Imaging, Toshiba) and contrast agent injection (Sonovue - Bracco) (DUSVRI) as a predictor of tumor response to this new treatment and of progression-free survival (PFS). Methods: Tumor vascularization in accessible targets was prospectively studied with DUSVRI, through a double-blind placebo controlled phase III study in MRCC. Examinations were performed with an Aplio sonograph (Toshiba) at baseline, and after 3 and 6 weeks on BAY (or the placebo) in patients with tumor targets accessible to US. The percentage of contrast uptake (Sonovue, Bracco) was evaluated in each tumor by two radiologists. Results were compared to CT scan studies at 6 weeks and to PFS, and will be analyzed after unblinding. Results: 30 patients have been enrolled and a total of 84 examinations have been performed to date: 30 before randomization, 28 at 3 weeks and 25 at 6 weeks. Preliminary results show a decrease in tumor vascularization in 10 out of 28 patients at 3 weeks and in 10 out of 25 patients at 6 weeks. The final results concerning 30 patients will be presented and a correlation with the CT-scan response at 6 weeks. Conclusions: DUSVRI is a new cost-effective and simple non invasive imaging technique. Its effectiveness in predicting the efficacy of BAY will be presented. No significant financial relationships to disclose.
DIABETES EXPERIMENTAL (2014)

retrograde into Bowman's space without mixing between compartments. Vacuum-assisted seeding improved cell delivery into vasculature and collecting systems: For the former, by demonstrating appropriate cells in the glomerular and peritubular capillary vasculature (e.g. GFP+). For the latter, by showing pancreatic islet cells in Bowman's space and tubules (e.g. insulin+). Conclusions: We have successfully developed protocols to transition from our rat model to pig kidneys for decellularization, sterilization and cell seeding. We selectively deployed cells antegrade through the vasculature into glomerular tufts, and retrograde up tubules into Bowman's space. Pancreatic islet cells successfully grew in the collecting system and demonstrated insulin production. This approach is very promising for tissue engineering a pig kidney trans-organ using a patient's iPSCs, and thereby crafting a vascularized pancreas xenotransplant.
Joint Texture and Geometry Optimization for RGB-D Reconstruction (2020)

Due to inevitable noises and quantization error, the reconstructed 3D models via RGB-D sensors always accompany geometric error and camera drifting, which consequently lead to blurring and unnatural texture mapping results. Most of the 3D reconstruction methods focus on either geometry refinement or texture improvement respectively, which subjectively decouples the inter-relationship between geometry and texture. In this paper, we propose a novel approach that can jointly optimize the camera poses, texture and geometry of the reconstructed model, and color consistency between the key-frames. Instead of computing Shape-From-Shading (SFS) expensively, our method directly optimizes the reconstructed mesh according to color and geometric consistency and high-boost normal cues, which can effectively overcome the texture-copy problem generated by SFS and achieve more detailed shape reconstruction. As the joint optimization involves multiple correlated terms, therefore, we further introduce an iterative framework to interleave the optimal state. The experiments demonstrate that our method can recover not only fine-scale geometry but also high-fidelity texture.
Growth and Primary Metabolism of Lettuce Seedlings (Lactuca sativa L.) Are Promoted by an Innovative Iron-Based Fenton-Composted Amendment (2023)

Information regarding the physiological and molecular plant responses to the treatment with new biofertilizers is limited. In this study, a fast-composting soil amendment obtained from solid waste by means of a Fenton reaction was assessed to evaluate the effects on the growth of <i>Lactuca sativa</i> L. var. longifolia seedlings. Growth rate, root biomass, chlorophyll concentration, and total soluble proteins of seedlings treated with the 2% fast-composting soil amendment showed significant increases in comparison with the control seedlings. Proteomic analysis revealed that the soil amendment induced the up-regulation of proteins belonging to photosynthesis machinery, carbohydrate metabolism, and promoted energy metabolism. Root proteomics indicated that the fast-composting soil amendment strongly induced the organs morphogenesis and development; root cap development, lateral root formation, and post-embryonic root morphogenesis were the main biological processes enriched by the treatment. Overall, our data suggest that the addition of the fast-composting soil amendment formulation to the base soils might ameliorate plant growth by inducing carbohydrate primary metabolism and the differentiation of a robust root system.
High frequency performance of GE high density interconnect modules (1993)

The layout and routing of high-frequency multichip modules (MCMs) require a detailed electromagnetic characterization of the interconnect structure in order to manage required design trade-offs intelligently. To provide this characterization for the GE high-density-interconnect (HDI) process, a number of test coupons containing a variety of transmission line structures were prepared. S-parameter data were measured using a vector network analyzer (VNA), and these measured data were compared to the theoretical predictions based upon classical transmission line theory. Reasonable agreement is obtained provided that skin and proximity effects in the lines and ground planes are taken into account and that the nonrectangular natures of the conductor cross sections are accurately modeled. Results suggest that insertion loss rather than crosstalk is likely to be limiting for frequencies up to 9 GHz. For 20% (2-dB) attenuation, line lengths are 3-12 cm for the frequency range of 1-9 GHz.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Britain's pattern of specialization in manufactured goods with developing countries and trade protection (1980)

This paper studies the influences determining the emergence of protectionist pressures in the industrial countries in response to market penetration by products from other countries, and analyzes the trigger points for taking protectionist measures. The problem is approached in two stages. Firstly, an explanatory outline for the pattern of manufacturing trade is mapped. Secondly, an attempt is made to explain the determinants of protectionist reaction. It is found that there is a strong association between the pattern of trade with developing countries and variables relating to aspects of human capital, a much weaker relationship between trade patterns with other groups of countries, and virtually none for changes in trade patterns over time. The measurement of what has been called the new protectionism, the selective use of non-traditional forms of trade barriers, directed mainly at non-industrial country competitors, presented considerable technical difficulties. However, use of a dummy variable permitted an analysis which showed a protectionist response to trade patterns apparently designed to negate or frustrate trade changes based upon the UK's comparative advantage in trade with developing countries.
Metallo-celluloses, 2 Synthesis of cellulose derivatives bearing lateral bis-terpyridine ruthenium(II) complexes (2003)

Abstract An efficient method is described for the simultaneous introduction of 4’-p-benzyl-2,2’:6’,2’’-terpyridine and benzyl side groups into cellulose. For this purpose, cellulose triacetate was treated in dimethyl sulfoxide/NaOH solution with mixtures of 4’-p-bromomethylphenyl-2,2’:6’,2’’-terpyridine and benzyl bromide. An almost quantitative conversion of the cellulose hydroxyl groups was reached when less than one terpyridine substituent was attached to the cellulose repeating units on average. At higher degrees of terpyridine substitution, some of the cellulose hydroxyl groups seem to remain unsubstituted. This conclusion has been drawn on the basis of NMR, IR and solubility measurements. We assume that steric hindrance of the bulky side groups is responsible for incomplete conversion. In a final step, the terpyridine substituents of the cellulose derivatives could be converted quantitatively into ruthenium(II) complexes via treatment with activated [Ru(tpy)Cl 3 ] in N,N-dimethylacetamide/1-butanol (tpy: 2,2’:6’,2’’-terpyridine).
Magnesium deficiency may predispose conversion of migraines (M) into chronic daily headaches (TRANSFORMED MIGRAINES-TM) with loss of responsiveness to magnesium infusions. (1996)

Clinical Pharmacology & Therapeutics (1996) 59, 196–196; doi: 10.1038/sj.clpt.1996.284
Symmetry and degeneracy in microstructured optical fibers (2001)

The symmetry of an optical waveguide determines its modal degeneracies. A fiber with rotational symmetry of order higher than 2 has modes that either are nondegenerate and support the complete fiber symmetry or are twofold degenerate pairs of lower symmetry. The latter case applies to the fundamental modes of perfect microstructured optical fibers, guaranteeing that such fibers are not birefringent. We explore two numerical methods and demonstrate their agreement with these symmetry constraints.
Dose-response relationship in phase I clinical trials: A European Drug Development Network (EDDN) collaboration study. (2011)

3084 Background: Alkylating agents have a strong dose effect relationship and this concept is used for development of novel cytotoxic (CTX) drugs. However, the need to reach MTD to obtain optimal benefit with molecularly targeted agents (MTA) is controversial. In this study we aimed to evaluate the relationship between dose and efficacy in a large cohort of phase I patients (pts) with refractory solid tumors. Methods: We retrospectively collected data on 2232 consecutive pts treated in phase I trials in 14 European institutions in 2005 - 2007. Inclusion criteria for this analysis were: a) pts treated within single agent studies where MTD was defined; b) RECIST response available. We used logistic and Cox regression models to study the relationship of dose (as continuous variable of % of MTD) with objective response rate (ORR), disease control rate (DC) and overall survival (OS). The clinical tumor growth rate (CTGR) - a log ratio of time between advanced disease diagnosis and phase I entry to number of treatment lines- was used to identify the impact of slow growing tumors on DC. Results: 1,015 pts were eligible (MTA 72%; CTX 28%). The ORR was 3% and DC at 3 and 6 months was 25% and 11%. Median CTGR was 22 weeks. There was no difference between ORR in pts receiving MTA or CTX but the DC rate at 3 and 6 months was higher for MTA (28% and 12%) than CTX (17% and 6%; p<0.01). This difference was attributed to the higher number of pts with slow growing tumors (CTGR > 20 weeks) treated with MTA (59%) vs. CTX (48%; p=0.001). Higher doses were associated with ORR to CTX agents (median dose: responders 92% vs. non-responders 62%; OR=6.4, p=0.06) but not to MTA. There was a relationship between dose and OS for CTX agents (univariate Cox regression HR=0.63 [95%CI 0.43-0.93], p=0.02) but not for MTA (HR=1.06 [95%CI 0.87-1.27], p=0.55). However in the multivariate model adjusted for clinical and demographic variables no relationship was found between dose and OS for either MTA or CTX. Conclusions: These results support current development of novel CTX agents based on MTD. We found no direct relationship between higher doses and ORR or OS with MTA in unselected pts. There is an urgent need to identify better biomarkers to guide dose escalation trials of MTA.
Speaker Verification Using Secure Binary Embeddings (2013)

Publication in the conference proceedings of EUSIPCO, Marrakech, Morocco, 2013
Gene Amplification and Expression of the <i>neu </i>(c-erbB-2) Sequence in Human Mammary Carcinoma (1988)

Alterations in the structure and expression of the neu oncogene were investigated in 15 human mammary tumors. In 7 of the samples (46%), amplification by the factor up to 14 was detected, some samples displaying an additional EcoRI restriction fragment at 3.4 kb. In tumor tissue with amplified neu sequences from which intact RNA was available, enhanced expression was noted. Correlation of the molecular data to clinical parameters indicated a correlation of the neu oncogene amplification to tumor grading and thus poor prognosis.
Endocrine disruptors: Revisiting concepts and dogma in toxicology (2017)

During the last decades, a large number of observations have shown that some exogenous substances could interfere with hormone levels or hormone action and could induce toxic effects. This has led to the identification of endocrine disruptors more than 25 years ago as a new class of toxic agents (Zoeller et al., 2014). Those widely used agents correspond to a variety of chemical classes, are not identified by their chemical structure or by a specific type of usage, but rather by their mechanisms of action; this is not unprecedented in toxicology since genotoxicants have also been identified by their mechanism of action, i.e. their ability to alter DNA structure and function.
A laser-induced heat flux technique for convective heat transfer measurements in high speed flows (1991)

Infrared thermography was used to monitor surface model temperatures with an applied heat flux due to a laser heating source in a supersonic flowfield. The technique was used to measure the local surface convective heat transfer coefficient distribution on a flat plate at nominal Mach numbers of 2.5, 3.0, 3.5, and 4.0. The flat plate boundary layer initially was laminar and became transitional in the measurement region. The experimentally determined convective heat transfer coefficients were generally higher than the theoretical predictions for flat plate laminar boundary layers. However, the results indicate that this nonintrusive optical measurement technique has the potential to measure surface convective heat transfer coefficients in high-speed flowfields. >
KS5 2 YEAR RESULTS FROM THE DANISH REGISTRY FOR KNEE LIGAMENT RECONSTRUCTIONS (2010)

Aim: In order to monitor the developments in anterior cruciate ligament (ACL) reconstruction and clinical outcome, a national clinical database for knee ligament surgery (Danish ACL Registry) was established in 2005. This study presents data for 2 years national production of ACL reconstructions from the Danish ACL registry. Methods: All clinics performing ACL reconstructions in Denmark reports to the database. The database is divided into surgeon data and patient data. The surgeon reports anamnestic, objective knee laxity and operative data including graft and implant choices. At one year control, complications, reoperations and objective knee laxity are recorded. The patient registers the KOOS knee score and Tegner function score preoperatively and at 1, 5 and 10 years follow-up. A specific set of indicators that define good diagnostic procedures and clinical outcome have been specified. Results: During the first 24months, more than 5000 knee-ligament reconstructions were registered. 84 % were primary ACL recontruction, 7,7 % were ACL revisions 8,4 %were multiligament reconstructions. 90 % of all departments reported to the database. 71 % of primary ACL reconstruction used hamstring tendon grafts and 21 % used patella tendon graft. Meniscus injuries were treated in 35 % of all patients. 17 % had significant cartilage lesions. Follow-up KOOS scores demonstrated specific differences between primary ACL, revision ACL and multiligament reconstructions. Conclusion: This study presents epidiomiology and follow-up data a national ACL reconstruction registry. These data will become new international reference materials for outcome measures before and after ACL surgery. The database will enable future monitoring of developments in ACL reconstruction techniques and outcome.
MIMO channel capacity of a measured indoor radio channel at 5.8 GHz (2002)

Multiple transmitters and receivers can be used to provide high link capacity in future wireless systems. Here, an analysis of indoor environment multiple-input-multiple-output measurements in the 5.8 GHz band is performed and the possible increase in capacity, utilizing multiple transmitters and receivers is examined. The investigation shows that in the measured indoor environment, the scattering is sufficiently rich to provide substantial link capacity increases. Furthermore, the effect of intra-element element spacing on, the channel capacity is studied. Finally the possible HiperLAN/2 MIMO channel capacity, based on the measurements, is examined.
Synthèse de nouveaux analogues originaux des granulatimide et isogranulatimides à visée antitumorale (2002)

Les cellules normales repondent aux dommages de l'ADN en activant des points de controle (en G1 et en G2) qui bloquent temporairement le cycle afin de permettre les reparations. La plupart des cellules cancereuses ne peuvent activer le point de controle en G1 du cycle cellulaire suite a une mutation du gene p53. Les inhibiteurs du point de controle en G2 vont augmenter l'efficacite d'agents endommageant l'ADN en conduisant les cellules tumorales vers une mitose precose et letale. La premiere partie est une etude bibliographique qui presente de facon detaillee les differentes phases et les points de controle du cycle cellulaire. Le passage a travers les differentes phases est controle par l'activation et l'inactivation de proteines kinases. Deux kinases sont essentielles dans le point de controle en G2 : les checkpoints kinases Chk1 et Chk2. Parmi les differents inhibiteurs et activateurs du point de controle en G2 presentes, nous nous sommes particulierement interesses a la famille de la granulatimide et des isogranulatimides qui semblent etre des inhibiteurs selectifs du point de controle en G2. La seconde partie, est consacree a la description des differentes syntheses qui ont permis l'elaboration de nouveaux analogues originaux des granulatimide et isogranulatimides. Ces nouveaux inhibiteurs ont ete obtenus soit en remplacant le motif imidazole par un autre motif a cinq chainons azote de type pyrrole ou maleimide soit en remplacant le noyau indolique par un motif azaindolique. Des etudes de relations structure-activite, ont ete entreprises pour chacune des series. Des modifications fonctionnelles ont ete apportees sur la partie imidique, aromatique et une partie osidique a ete introduite dans l'une des series. Une derniere partie a trait aux tests biologiques realises sur nos molecules : activites antiproliferatives sur differentes lignees cellulaires cancereuses, effet sur le cycle cellulaire de cellules leucemiques murines L1210
Modification of the sensitivity of glucose sensor implanted into subcutaneous tissue. (1996)

The mechanism of reducing the glucose sensitivity of sensors implanted into the subcutaneous tissue of the normal rat was evaluated (n = 10) by comparing sensitivities observed in vitro and in vivo. In vivo sensitivity was significantly lower than that observed in vitro before implantation (p < 0.005). Most interestingly, in vitro sensitivity immediately after explanation did not differ from that in vivo and increased progressively during rinsing (p < 0.02 after 30 min). These results demonstrate that the reduction of in vivo sensitivity was not due to a local factor or factors but to a reversible alteration of the glucose sensor characteristics induced in vivo by some local factor(s). This suggests that modifications of the outer sensor membrane, the nature of which remains to be determined, may prevent this effect and resolve the problem.
Fetal Origin of the Posterior Cerebral Artery Produces Left-Right Asymmetry on Perfusion Imaging (2009)

Faster perfusion transit times are seen for parameters sensitive to macrovascular transit effects (eg, FMT and T(max)) ipsilateral to fetal origin of the PCA in proportion to the degree of arterial asymmetry. Knowledge of this normal variation is critical in the interpretation of perfusion studies because asymmetry could mimic cerebrovascular pathology.