gebhart/patrepeval huggingface dataset:
Metabolic disorders in children (1994)

This year has seen major progress in gene therapy, particularly that directed to the liver. Genes have been characterized for Wilson's disease, Krabbe's disease, Canavan's disease, adrenoleukodystrophy, glucose-6-phosphatase, and long-chain 3-hydroxyacyl-CoA dehydrogenase. Moreover, the identification of common mutations in many conditions promises to help with diagnosis and genetic counseling. The drama of progress in molecular biology can easily overshadow other research, but the application of tandem mass spectrometry to neonatal screening is a major advance. Other important papers concern the use of Lorenzo's oil in adrenoleukodystrophy and revised dietary recommendations for the treatment of phenylketonuria. This review focuses predominantly on diseases that affect the brain, but important advances in other conditions have been included.
Novel Cardiac Coordinate Modeling System for Three-Dimensional Quantification of Inflow Cannula Malposition of HeartMate II LVADs (2017)

Optimal function of left ventricular assist devices (LVADs) depends on proper alignment of the inflow cannula (IC). Quantitative guidelines for IC angulation are lacking because of variation in cardiac geometry and difficulty in analyzing three-dimensional (3D) cannula orientation relative to the left ventricle (LV). Based on contrast-enhanced computed tomography images from five normal and five clinically malpositioned IC cases in patients with HeartMate II LVADs, we developed a method for 3D quantification of IC malpositioning. Using Mimics image software (Materialise, Leuven, Belgium), the native heart, major arteries, and LVAD were segmented to create patient-specific 3D models, allowing LV cavity volume and long-axis length to be measured directly. The deviation of the IC was quantified in a cylindrical coordinate system at the IC insertion point relative to the mitral valve and septum, and IC occlusion was assessed by the distance between cannula inlet and the proximal endocardium. Compared with normal cases, patients with malpositioned pumps had shorter LV length (p = 0.03) and reduced pump pocket depth (p = 0.009). Malpositioned pumps may experience greater obstruction by the nearby myocardium. This quantitative 3D modeling tool may help identify different modes of pump malalignment and migration and may facilitate preoperative planning and minimally invasive approaches via virtual LVAD implantation.
Terrain Change Detection Using ASTER Optical Satellite Imagery Along the Kunlun fault, Tibet (2004)

Terrain changes are manifested in satellite images as pixel offsets. A pixel offset represents the apparent difference in the position of corresponding pixels in two time-separated images of the same portion of the Earth's surface. Previous work on Satellite Pour l'Observation de la Terre (SPOT) optical data has shown the feasibility of using optical imagery for terrain change detection using both “imageodesy” and Fourier analysis. This thesis attempts similar change detection with Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) imagery. The change detection methods used in this thesis are Fourier analysis, “imageodesy” using cross-correlation, and wavelet analysis. The benefits of using ASTER are its dramatically lower cost compared to SPOT, the capability of generating DEMs from ASTER imagery, and the redundancy afforded by ASTER's stereo capability. The latter may aid in increasing the precision of terrain change measurements made using optical image processing techniques. Three test cases were used to test the three change detection methods. All test cases capture different regions of the Kunlun fault area in China, and have different time separation windows, where each window represents a different time interval from two years to two month. The Kunlun fault region experienced a Ms = 8.1 earthquake known as the Kokoxili earthquake on November 14, 2001. This earthquake caused a maximum of 16.3 m along the fault. Results have shown terrain change detection works best using the Fourier and wavelet analysis techniques. The Fourier analysis method detected the left-lateral slip direction and magnitude (4.5 m) in the proximal area of the Kunlun fault very well. Wavelet analysis was very effective at delineating fault scarps caused by the 2001 Kokoxili earthquake.
Studies on the use of two different magnesia-carbon recyclates as secondary raw material for MgO–C refractories (2023)

Two magnesia-carbon (MgO–C) recyclates were investigated with respect to their utilization as raw materials for MgO–C refractories. X-ray diffraction and backscattered electron diffraction were used for phase analysis of the recyclate aggregates. In addition, the gas released from one of the recyclates when it came into contact with water was analyzed in a mass spectrometer. MgO–C samples with different recyclate contents were produced. During coking, the samples showed different behavior depending on the recyclate used. Whereas those containing the first recyclate showed a slight shrinkage, a significant increase in volume was observed in the case of the specimens that contained the second recyclate. The volume increase could be reduced by thermal pretreatment of this recyclate at 380 °C. As a result, better bulk density and porosity values were obtained. However, an even stronger positive effect was achieved by replacing the pitch-based binder used in the binder system with a novolak-based.
Fibrolytic Enzyme Supplements for Dairy Cows in Early Lactation (1999)

Twenty multiparous lactating Holstein cows in early lactation were used to investigate effects of exogenous fibrolytic enzyme supplementation on dry matter intake, milk production, and digestibility. Cows were blocked according to parity, expected calving date, and milk yield in the previous lactation, and then randomly assigned after calving to two treatments: control or enzyme. The enzyme mixture, which contained mainly xylanase and cellulase activities (Pro-Mote, Biovance Technol. Inc., Omaha, NE), was added to the concentrate to supply 1.3 g/kg of total mixed ration (dry matter basis). The total mixed rations contained 24% corn silage, 15% alfalfa hay, and 61% barley concentrate (dry matter basis) and were offered for ad libitum intake. Enzyme addition did not affect dry matter intake. However, total digestibility of nutrients, determined using Cr2O3, was dramatically increased by enzyme treatment (dry matter, 61.7 vs. 69.1%; neutral detergent fiber, 42.5 vs. 51.0%; acid detergent fiber, 31.7 vs. 41.9%; crude protein, 61.7 vs. 69.8%). Consequently, milk yield tended to increase (35.9 vs. 39.5 kg/d). Percentage of milk fat was lower, and percentages of milk protein tended to be lower for cows fed a diet supplemented with enzymes, such that component yields were similar for cows fed either diet. Energy deficiency was numerically lower for cows fed a diet supplemented with enzymes than for cows fed the control diet (-3.62 vs. -3.33 Mcal/d). Supplementing dairy cow diets with a fibrolytic enzyme mixture has the potential to enhance milk yield and nutrient digestibility of cows in early lactation without changing feed intake.
Sustainable Forest Management Graduate Education (2002)

During the past year, members of the Sustainable Forestry Partnership, in cooperation with other forestry schools, with funding from the several private foundations and USDA, have been exploring approaches for enhancing graduate education programs to foster adoption of Sustainable Forest Management curriculum concepts. Ten National Association of Professional Forestry Schools and Colleges (NAPFSC) members have conducted two focus groups to gain understanding of curriculum opportunities and challenges. The findings from these focus groups will be reported out at a national conference in Kansas City in November 2001. That assembled group will begin to discuss ways and approaches for cooperating across institutions to share resources to engage expanded opportunities for enhancing education on sustainable forestry. We will quickly present the findings from the Kansas City workshop, and then explore how we can further the discussion, foster partnerships, and consider how we can develop and implement new reaching strategies.
Evaluation guidelines for microprocessor-based systems important to safety (1983)

gov (NCT03404544); registered 19 January 2018.
Stearic acids atsn-1, 3 positions of TAG are more efficient at limiting fat deposition than palmitic and oleic acids in C57BL/6 mice (2013)

In the present study, we investigated the effect of long-acyl chain SFA, namely palmitic acid (16:0) and stearic acid (18:0), at sn-1, 3 positions of TAG on obesity. Throughout the 15 weeks of the experimental period, C57BL/6 mice were fed diets fortified with cocoa butter, sal stearin (SAL), palm mid fraction (PMF) and high-oleic sunflower oil (HOS). The sn-1, 3 positions were varied by 16:0, 18:0 and 18:1, whilst the sn-2 position was preserved with 18:1. The HOS-enriched diet was found to lead to the highest fat deposition. This was in accordance with our previous postulation. Upon normalisation of total fat deposited with food intake to obtain the fat:feed ratio, interestingly, mice fed the SAL-enriched diet exhibited significantly lower visceral fat/feed and total fat/feed compared with those fed the PMF-enriched diet, despite their similarity in SFA-unsaturated fatty acid-SFA profile. That long-chain SFA at sn-1, 3 positions concomitantly with an unsaturated FA at the sn-2 position exert an obesity-reducing effect was further validated. The present study is the first of its kind to demonstrate that SFA of different chain lengths at sn-1, 3 positions exert profound effects on fat accretion.
Inhibition of T lymphocyte activation by cAMP is associated with down-regulation of two parallel mitogen-activated protein kinase pathways, the extracellular signal-related kinase and c-Jun N-terminal kinase (1996)

The induction of T cell proliferation requires signals from the TCR and a co-receptor molecule, such as CD28, that activate parallel and partially cross-reactive signaling pathways. These pathways are disrupted by agonists that utilize adenylate cyclase and cAMP-dependent protein kinase A (PKA). We found that the adenylate cyclase activator, forskolin, inhibits anti-CD3-induced shift in Lck electrophoretic mobility, suggesting an intervention at the TCR-coupled phosphoinositide turnover that precedes the activation of PKC. The shift of Lck following direct PKC activation by 12-O-tetradecanoyl phorbol 13-acetate, which bypasses early receptor-triggered biochemical events, is insensitive to forskolin. Nevertheless, forskolin also inhibits PKC downstream events, such as c-jun expression, which is critical for the activation process of T cells. To further analyze potential cross points between positively and negatively regulating signaling pathways in T cells, we tested the effects of activators of the adenylate cyclase or PKA on two parallel mitogen-activated protein kinase signaling pathways mediated by extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase. Using a PKC-specific inhibitor, GF109203X, or PKC-depleted T cells, we found that a large part of the anti-CD3-induced ERK activation is PKC dependent. Both PKC-dependent and -independent activation of ERK were sensitive to inhibition by forskolin or a cell-permeable cAMP analogue, dbcAMP. Furthermore, the effect of 12-O-tetradecanoyl phorbol 13-acetate and ionomycin, which synergized to fully activate c-Jun N-terminal kinase, was also sensitive to inhibition by forskolin. Our results suggest that PKA inhibits T cell activation by interfering with multiple events along the two signaling pathways operating downstream of the TCR and the CD28 co-receptor molecules.
Supplementary Table S7 from Identification of Kinase Inhibitor Targets in the Lung Cancer Microenvironment by Chemical and Phosphoproteomics (2023)

&lt;p&gt;Table S7. Mass spectrometry data of phosphoproteomics experiments with eluates from c-dasatinib and c-sunitinib affinity chromatography eluates across all samples from primary NSCLC tissues, cell lines and cell line-derived mouse xenografts.&lt;/p&gt;
Bioinspired core‐crosslinked micelles from thymine‐functionalized amphiphilic block copolymers: Hydrogen bonding and photo‐crosslinking study (2011)

Abstract Bioinspired core‐bound polymeric micelles, based on hydrogen bonding and photo‐crosslinking, of thymine have been prepared from poly(vinylbenzylthymine)‐ b ‐poly(vinylbenzyltriethylammonium chloride). The amphiphilic block copolymer was synthesized by 2,2‐tetramethylpiperidin‐1‐oxyl‐mediated living radical polymerization in water/ethylene glycol solution. Micelle characterization and critical micelle concentration measurements demonstrated that the hydrogen bonding of the attached thymine units stabilizes the micelles. Further, core‐crosslinked polymeric micelles were formed by ultraviolet (UV) radiation showing that the stability of the micelle could be controlled by the UV crosslinking of the attached thymines. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011
Embedding, Evolution, and Validation of Model-Driven Spreadsheets (2014)

This paper proposes and validates a model-driven software engineering technique for spreadsheets. The technique that we envision builds on the embedding of spreadsheet models under a widely used spreadsheet system. This means that we enable the creation and evolution of spreadsheet models under a spreadsheet system. More precisely, we embed ClassSheets, a visual language with a syntax similar to the one offered by common spreadsheets, that was created with the aim of specifying spreadsheets. Our embedding allows models and their conforming instances to be developed under the same environment. In practice, this convenient environment enhances evolution steps at the model level while the corresponding instance is automatically co-evolved. Finally, we have designed and conducted an empirical study with human users in order to assess our technique in production environments. The results of this study are promising and suggest that productivity gains are realizable under our model-driven spreadsheet development setting.
Diverse blended learning (2013)

The advancements in technologies have created possibilities for innovative teaching and learning methods in higher education. These possibilities include mixing of technology-based learning with the traditional face-to-face teaching and learning strategies to maximize the usage of human expertise and technology resources for the benefit of the students. As existing pedagogies are appended with new ones, there is a need to assess their effectiveness from the students' perspective. This research analyses and presents the findings of different virtual learning environments, where it involved second and final year computer and information science undergraduate students at a higher educational organization in the United Arab Emirates. The studies involved two international courses, where pre-defined learning outcomes are achieved, and assessments are carried out successfully. The investigation undertaken in this study gave an indication of how effective virtual international learning was, as teaching strategies.
Case 26-2016 (2016)

A 28-year-old woman presented with intractable back pain with radiation to the leg. Examination of biopsy specimens revealed a giant-cell tumor of bone. Management decisions were made.
Martensite-like transition and spin-glass behavior in nanocrystalline Pr0.5Ca0.5MnO3 (2012)

We report on isothermal pulsed (20 ms) field magnetization, temperature dependent AC - susceptibility, and the static low magnetic field measurements carried out on 10 nm sized Pr0.5Ca0.5MnO3 nanoparticles (PCMO10). The saturation field for the magnetization of PCMO10 (~ 250 kOe) is found to be reduced in comparison with that of bulk PCMO (~300 kOe). With increasing temperature, the critical magnetic field required to 'melt' the residual charge-ordered phase decays exponentially while the field transition range broadens, which is indicative of a Martensite-like transition. The AC - susceptibility data indicate the presence of a frequency-dependent freezing temperature, satisfying the conventional Vogel-Fulcher and power laws, pointing to the existence of a spin-glass-like disordered magnetic phase. The present results lead to a better understanding of manganite physics and might prove helpful for practical applications.
Ica By Mutual Information Minimization: An Approach For Avoiding Local Minima (2005)

Publication in the conference proceedings of EUSIPCO, Antalya, Turkey, 2005
I (2008)

<sc>Strether’s first</sc> question*, when he reached the hotel, was about his friend; yet on his learning that Waymarsh was apparently not to arrive till evening he was not wholly disconcerted. A telegram from him bespeaking a room ‘only if not noisy’, reply...
The effect of exposure to arsenic flow on the optical properties of quantum dot arrays in the InAs/GaAs(100) system (2004)

The optical properties of quantum dot arrays in the MBE-grown InAs/GaAs(100) epitaxial system with an effective InAs layer thickness of 1.9 monolayers were studied in samples exposed to the beam of As4 for various times after switching off the In beam. The results of photoluminescence measurements showed that the emission wavelength increased with the exposure time within certain limits. This behavior agrees with predictions of the kinetic model of the initial stage of quantum dot formation.
Experimental Study of Coexistence Issues Between IEEE 802.11b and IEEE 802.15.4 Wireless Networks (2008)

Coexistence issues between IEEE 802.11b wireless communication networks and IEEE 802.15.4 wireless sensor networks, operating over the 2.4-GHz industrial, scientific, and medical band, are assessed. In particular, meaningful experiments that are performed through a suitable testbed are presented. Such experiments involve both the physical layer, through measurements of channel power and the SIR, and the network/transport layer, by means of packet loss ratio estimations. Different configurations of the testbed are considered; major characteristics, such as the packet rate, the packet size, the SIR, and the network topology, are varied. The purpose of this paper is to gain helpful information and hints to efficiently face coexistence problems between such networks and optimize their setup in some real-life conditions. Details concerning the testbed, the measurement procedure, and the performed experiments are provided.
Generation of tumour-rejecting anti-carbohydrate monoclonal antibodies using melanoma modified with Fas ligand (2008)

Carbohydrate antigens such as glycolipids and glycoproteins are over-expressed in a variety of cancers and have therefore been identified as ideal candidates for tumour vaccines. Detection of anti-carbohydrate antibodies is associated with a good prognosis in cancer patients. However, generation of an efficient adaptive immune response has been hampered by the low immunogenicity of carbohydrates due to tolerance. Here, we describe a method by which tumour-rejecting antibodies directed against carbohydrates can be elicited in two different melanoma mouse models. Thus, using the murine melanoma B16F10 over-expressing Fas ligand (FasL), we have generated mAbs against cancer carbohydrate antigens expressed by the melanoma. Importantly, passive transfer of mAbs resulted in rejection of melanoma in vivo. Their protective effect in vivo was dependent on FcR and in vitro antibody-dependent cellular phagocytosis. They were also able to delay tumour growth when injected after the tumour was established. FasL-expressing tumours as an adjuvant are a novel way to generate anti-carbohydrate antibodies able to reject tumours in vivo.
Surface anchoring and dynamics of thiolated azobenzene molecules on Au(111) (2009)

We have investigated the temperature-dependent behavior of thiolated azobenzene molecules on Au(111) using scanning tunneling microscopy. The addition of a thiol functional group to azobenzene molecules leads to increased surface anchoring of single azobenzene molecules to gold. Thiolated azobenzene shows diverse surface morphology and does not form well-ordered structures at low coverage. At elevated temperatures, anchored molecules are observed to spin in place via hindered rotation. By measuring the number of rotating molecules as a function of temperature and using a simple model, we are able to estimate the energy barrier and attempt frequency for thermally induced hindered rotation to be 102+/-3 meV and 110+/-2 GHz, respectively.
VLSI architectures for computing X mod m (1995)

The implementation of residue number system based arithmetic processors has been made feasible by the recent developments in microelectronics. New VLSI architectures are proposed for computing the integer module operation X mod m, when m is restricted to the values 2k, 2k±1 and composite numbers whose mutually prime factors fall in the above category. Two different design methodologies, namely the recursive and partition methods are presented, and their respective VLSI computational complexities are analysed. A VLSI chip that computes X mod m, where X is a 16-bit number and m=3, 5, 6, 7, 9 and 10, has been implemented using the proposed schemes in 3 µm CMOS technology, and typical measurements have yielded a propagation delay of less than 109 ns.
Profile Angle Defines Soft Tissue Chin Position in Adults (2014)

Objectives: To identify the soft tissue chin position relative to the upper part of the face wherein the Frankfort horizontal (FH) plane intersects the nasal bridge and to define a specific measurement that might benefit different racial groups and their treatment goals.Materials and Methods: Forty-eight Taiwanese adults (23 males and 25 females), selected based on criteria consisting of proper occlusion, skeletal Class I pattern, lip competence in repose, and within the Esthetic (E) line confined standard, were subjected to standard soft tissue facial analyses. The results were used to compare with those of the White norm.Results: Analyses revealed that the means of the nose of our sample were shorter than those of the White, but those of the upper lip and chin were thicker. Despite the measured counter or unfavorable differences, all samples still a bide E line criteria, suggesting that chin position in mandible must justify the harmonious facial profile. Moreover, a facial angle was constructed between the FH plane and a profile line drawn from a point where the FH plane meets the nasal outline tangentially to soft-tissue chin. A consistent value of 84 degrees was obtained in both male and female.Conclusion: The measurement of the profile angle can identify and localize the chin point. Even though the length of the nose and the thickness of the lips and chin may vary, the proper chin position may eventually justify a pleasing facial profile among different ethnic origins.
Supplementary Figure 4 from Negative Regulation of p53 by the Long Isoform of ErbB3 Binding Protein Ebp1 in Brain Tumors (2023)

Supplementary Figure 4 from Negative Regulation of p53 by the Long Isoform of ErbB3 Binding Protein Ebp1 in Brain Tumors
Permanent magnet flux switching motor for low energy axial fans (2005)

In this paper, a permanent magnet flux switching motor (PMFSM) is presented as an alternative to the more familiar brushless DC motor (BDC) used in low energy consumption axial fans. The PMFSM has permanent magnets as a part of the stator structure which also contains an armature winding. The rotor is a simple steel, salient pole structure. Simulated and experimental results are shown that demonstrate the proposed PMFSM can have improved efficiency compared with a comparable BDC motor and drive.