gebhart/patrepeval huggingface dataset:
In Vitro Evidence for the Presence of Hematopoietic Stem Cells in the Adult Human Liver (1999)

Previous studies have identified novel lymphoid phenotypes in the adult human liver and provided evidence to suggest that lymphoid differentiation can occur locally in this organ. The aim of this study was to examine the adult human liver for the presence of hematopoietic stem cells that may provide the necessary precursor population for local hematopoietic and lymphoid differentiation. Hepatic mononuclear cells (HMNC) were extracted from normal adult liver biopsy specimens using a combination of mechanical disruption and enzymatic digestion. The stem cell marker CD34 was found on 0.81% to 2.35% of isolated HMNCs by flow cytometry. CD34(+) HMNCs were positively selected using magnetically labeled beads, and the enriched population was further examined for surface markers characteristically expressed by immature hematopoietic cells and early progenitors. CD45 was expressed by 49% (+/-23%) of CD34(+) HMNCs, indicating their hematopoietic origin. CD38, one of the first markers to be expressed by developing progenitor cells was found on 50% (+/-22%) of CD34(+) HMNCs indicating the presence of both pluripotent stem cells and committed precursors. The majority (90%) of CD34(+) HMNCs coexpressed the activation marker human leukocyte antigen DR, consistent with actively cycling cells. Functional maturation of these hepatic progenitors was shown by the detection of multilineage hematopoietic colony formation after tissue culture. Erythroid (BFU-E), granulocyte-monocyte (CFU-GM), and mixed colonies (CFU-GEMM) were detected after culture of unseparated HMNCs and the enriched CD34(+) HMNC population; 14.3 +/- 13.2 (mean +/- SD) BFU-E, 3.1 +/- 3.1 CFU-GM, and 0.4 +/- 0.9 CFU-GEMM per 1 x 10(5) unseparated HMNCs and 16.0 +/- 9.5 BFU-E and 1.7 +/- 0.9 CFU-GM were identified per 2.4 x 10(3) CD34(+) HMNCs plated. The detection of surface markers characteristic of immature hematopoietic cells and colony formation in tissue culture provides evidence for the presence of hematopoietic stem cells and early progenitor cells in the adult human liver. This would suggest that the adult human liver continues to contribute to hematopoiesis and may be an important site for the differentiation of lymphohematopoietic cells involved in disease states, such as autoimmune hepatitis and graft rejection after liver transplantation.
Multi modal user interaction in an automatic pool trainer (2003)

This paper presents the human-computer interaction in an automatic pool trainer currently being developed at the Center for PersonKommunikation, Aalborg University. The aim of the system is to automate (parts of) the learning process, in this case of the game of pool. The automated pool trainer (APT) utilises multi modal, agent driven user-system communication, to facilitate the user interaction. To allow the user the necessary freedom of movement when addressing the task, system output is presented on a wall-mounted screen and is augmented by a laser drawing lines and points directly on the pool table surface. User interaction is either carried out via a spoken dialogue with an animated interface agent, or by using a touch screen panel. The paper describes the philosophy on which the system is designed, as well as the system architecture and individual modules. The user interaction is described and the paper concludes with a presentation of some test results and a discussion of the suitability of the presented and similar systems.
ChemInform Abstract: Nickel(II) Complex‐Catalyzed Epoxidation of Olefins with Molecular Oxygen and Primary Alcohol. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Fabrication of CeO2 nanoparticles embedded in polysaccharide hydrogel and their application in skin wound healing (2020)

Nanocrystalline cerium oxide (CeO 2 ) is considered as one of the most promising inorganic materials for biomedical purposes. The unique redoxactivity, high biocompatibility and low toxicity of CeO 2 nanoparticles open great prospects in their biomedical usage as a therapeutic agent, including acceleration of skin regeneration processes after injuries of various etiologies. As part of this work, a hydrogel based on natural polysaccharides modified with CeO 2 nanoparticles was synthesized and its therapeutic efficacy in the treatment of planar full thickness and linear skin wounds in rats was shown. Basing on wound surface area measurements, results of skin wounds tensiometry and histological analysis it was found that polysaccharide hydrogel significantly reduces planar and linear wound healing times. Polysaccharide hydrogel modified with CeO 2 nanoparticles facilitates rapid reduction of wound defect area and the scar formation with complete tissue regeneration in the wound area. Additionally, composite hydrogels reduce the manifestations of non-specific signs of inflammation and intoxication. Thus, polysaccharide hydrogel modified with CeO 2 nanoparticles can be regarded as an effective wound healing substance in the therapy of skin injuries of various etiologies.
Fiber Ropes for Ocean Engineering in the 21st Century (1992)

Recent advances in synthetic fiber ropes will greatly influence the practice of civil engineering in the oceans during the 21st Century. New fibers have moduli almost as high as steel and are stronger than steel. Fiber ropes are light weight and easy to handle. They do not corrode. New rope and mooring system designs can compensate for the inferior wear properties of fibers and take full advantage of the other fiber properties. Some fiber ropes have tension and bending fatigue performance superior to those of wire ropes. The newer forms of fiber ropes are thus ideal for many ocean engineering applications.
SYNFORM ISSUE 2017/4 (2017)

In this brief editorial I would like to anticipate that the next issue of SYNFORM is going to be a VERY special one.Guess why.It is a secret for now, I am not going to give any running commentary of our plans for the moment, but our most loyal readers may have already understood.Just a tip: it is an anniversary.Could it be my wedding anniversary?Or maybe when our beloved cat Zorro joined the Zanda family?Or perhaps my 25 th birthday?Naaahhh… something more important, way more important… bear with me for another month and you will find out!For the moment, let me just introduce this April issue of SYNFORM.The first story covers a new hypervalent iodine-promoted process -developed by M. Fujita (Japan) -that produces fused cyclic ethers and amines in enantioselective manner from alkenes.The second article is a Young Career Focus interview with T. Noël (The Netherlands) who tells us about his scientific interest and research plans.The third contribution leads us to the novel radical reaction for synthesizing arylboronates developed by L. Jiao (P.R. of China).And the closing article takes us to the nearly uncharted territory of stereocontrolled remote Csp 3 -H functionalization producing structurally elaborated ketones developed by C. Nevado (Switzerland).Once you have read this one, look out for the next SYNFORM issue!
Motion‐compensated fat‐water imaging for 3D cardiac MRI at ultra‐high fields (2022)

This work demonstrates the feasibility of 3D fat-water imaging at UHF for the entire human heart despite spatial and temporal <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msubsup><mml:mi>B</mml:mi><mml:mn>1</mml:mn><mml:mo>+</mml:mo></mml:msubsup></mml:math> and B<sub>0</sub> variations, as well as respiratory and cardiac motion.
SPM-based data storage for ultrahigh density recording (1997)

The possibility of SPM-based data storage is described regarding both its recording density and readout speed for ultrahigh density data storage. We consider their gap control to achieve high-speed readout. Suitable SPM-based storages are selected and their details are studied. As a result, scanning near-field optical microscope (SNOM)- and atomic force microscope (AFM)-based storages are expected to be candidates for future storage. SNOM-based storage is for . AFM-based storage is for . Using new force modulation AFM pit recording, an ultrahigh recording density of and a readout speed of are demonstrated.
Myeloablative high-dose therapy with autologous stem cell transplantation versus chemotherapy or immuno-chemotherapy for follicular lymphoma in adults (2009)

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To compare the efficacy of myeloablative high‐dose chemotherapy with autologous stem cell transplantation to chemotherapy or immuno‐chemotherapy in first‐line or relapsed follicular lymphoma.
Beams for Gammasphere at the LBNL 88-inch cyclotron (2002)

The new transport system from the 88-inch cyclotron to the Gammasphere facility is described. Included are discussions of the ECR sources, operation, beam diagnostics, mechanical construction, vacuum system and beam optics.
A Comparison of Piezoelectric Transformer AC/DC Converters with Current Doubler and Voltage Doubler Rectifiers (2004)

The objective of this study was to develop recommendations for an optimal design of piezoelectric transformer (PT) AC/DC converters. The paper presents a comprehensive comparison of the two commonly used rectifier topologies in a PT based power converters: current doubler and voltage doubler rectifiers. The advantages and disadvantages of the two rectifiers were investigated and the range of their applications with respect to output current, voltage, power capability, load resistance etc.-was delineated. Generic parameters are proposed and used to derive normalized and closed form equations that can help choosing a PT for a given set of requirements. Simulation and experimental results were found to be in a good agreement with the derivation of the theoretical analysis.
[P2–409]: THE ROLE OF HIPPOCAMPAL SUBFIELDS IN THE ATROPHY PROCESS IN ALZHEIMER's DISEASE: AN IN‐VIVO STUDY OF THE ADNI COHORT (2017)

Hippocampal atrophy is an established biomarker for Alzheimer's Disease (AD). However, the hippocampus comprises different substructures that may be differentially affected in AD. Reliable segmentation on in vivo MRI scans acquired at standard field strengths has proven difficult. Here we use a novel, validated segmentation tool to investigate hippocampal subfield volumes in AD in the ADNI cohort. Whole hippocampus and twelve substructures were segmented from longitudinal T1-weighted MRI scans of 1,076 subjects using a validated algorithm distributed with FreeSurfer 6.0 (1). Subjects were diagnosed as control (n=375), mild cognitive impairment (MCI; N=557) or AD (n=144) at the time of the baseline MRI scan. Logistic regression models were used to estimate the predictive effect of normalized average bilateral subfield volumes on diagnosis. Normalisation was performed dividing by intracranial volume (ICV) or hippocampal volume. Models were controlled for sex, age and APOE4 status. We extracted log (Odds Ratio) from four models: Controls-vs-MCI, Controls-vs-AD, MCI-vs-AD and MCI stable-vs-converters. Log(OR) were compared to assess subfields’ ability to discriminate diagnostic classes. Most subfields showed discriminative power comparable to the whole hippocampus. The molecular layer was the only structure whose ICV-normalised volume slightly outperformed hippocampus in both the Controls-vs-AD and MCI stable-vs-converters classification. The CA3 and CA4 fields were affected earlier in the disease; their log(OR) was lower in the Controls-vs-MCI than in the MCI-vs-AD model (Figure 1, top). Likewise, hippocampal fissure (normalised to hippocampal volume) showed a better discrimination in control-vs-MCI than in MCI-vs-AD (Figure 2, top). Conversely, atrophy in the fimbria exhibited a better discrimination in MCI-vs-AD than in control-vs-MCI (Figure 1, top); further, when normalised to the entire hippocampal volume it demonstrated excellent performance in predicting conversion from MCI to AD (Figure 2, bottom). Discrimination between disease groups could not be reliably improved by studying hippocampal subfields. However, our analysis suggests that some subfields (CA3 and CA4) are affected earlier and others (fimbria) later in the disease. Thus, hippocampal subfield analysis may allow a better disease staging than the analysis of the entire hippocampus alone, but validation with higher resolution data might be necessary. (1) Iglesias et al., Neuroimage 2015;115:117–37. Log(Odds Ratio) for the ICV-normalised subfields volume, for twelve substructures and whole hippocampus, extracted from four logistic regression models: Controls-vs-MCl, Controls-vs-AD, MCl-vs-AD (top); MCl stable-vs-converter (bottom). Log(Odds Ratio) for percentage of hippocampal volume, for twelve substructures and whole hippocampus, extracted from four logistic regression models: Controls-vs-MCI, Controls-vs-AD, MCl-vs-AD (top); MCI stable-vs-converters (bottom).
Dependence of laser accelerated protons on laser energy following the interaction of defocused, intense laser pulses with ultra-thin targets (2011)

Abstract The scaling of the flux and maximum energy of laser-driven sheath-accelerated protons has been investigated as a function of laser pulse energy in the range of 15–380 mJ at intensities of 10 16 –10 18 W/cm 2 . The pulse duration and target thickness were fixed at 40 fs and 25 nm, respectively, while the laser focal spot size and drive energy were varied. Our results indicate that while the maximum proton energy is dependent on the laser energy and laser spot diameter, the proton flux is primarily related to the laser pulse energy under the conditions studied here. Our measurements show that increasing the laser energy by an order of magnitude results in a more than 500-fold increase in the observed proton flux. Whereas, an order of magnitude increase in the laser intensity generated by decreasing the laser focal spot size, at constant laser energy, gives rise to less than a tenfold increase in observed proton flux.
Barbiturate- and Thiobarbituarte-Based s-Triazine Hydrazone Derivatives with Promising Antiproliferative Activities (2020)

A new class of compounds, which include <i>s</i>-triazine with pyrimidinetrione or thiopyrimidinedione moiety through a hydrazone linkage, were synthesized and characterized. The newly synthesized <i>s</i>-triazine hydrazone derivatives were evaluated <i>in vitro</i> against four cancer cell lines: A549, HepG2, HCT-116, and MCF-7. Several derivatives showed growth inhibition activity in the low microgram range. The results reveal that the barbiturate derivatives showed poor to no activity, while thiobarbiturate derivatives showed better activity than the analogues barbiturate derivatives. The substituents on the s-triazine moiety have a great effect on the antiproliferative activity, where derivatives with the piperidino and diethylamino on the <i>s</i>-triazine ring (<b>5h</b>) showed the highest activity against all of the tested cell lines (IC<sub>50</sub> 1.6 ± 0.6, 3.8 ± 0.3, 1.9 ± 0.4, and 1.2± 0.5 μg/mL for the tested cell lines A549, HepG2, HCT-116, and MCF-7, respectively). These results indicate that thiobarbiturates-<i>s</i>-triazine hydrazone derivatives may provide an excellent scaffold for the development of an anticancer drug candidate.
Transinfected Wolbachia have minimal effects on male reproductive success in Aedes aegypti (2013)

The benign strain of Wolbachia, wMel causes similar reductions in fecundity as the more virulent, wMelPop, and neither are too great that they should not still spread given the action of CI. The ability of Wolbachia-infected males to repeat mate as frequently as wildtype mosquitoes indicates that they will be very good agents of delivering CI in field release populations.
A DSOGI-FLL-Based Dead-Time Elimination PWM for Three-Phase Power Converters (2018)

The dead-time elimination pulsewidth modulation (PWM) enables the drive pulses of the upper and the lower switching devices to alternate according to the current polarity, thus abandoning the dead time and essentially avoiding the dead-time effect in power converters. However, the current zero crossing will be distorted by the current jump generated by the drive-pulse alternation, and the current zero-crossing distortion will be further intensified if errors exist in the detected current polarity. Thanks to the noise-attenuation and frequency-adaptability characteristics of the double second-order generalized integrator frequency-locked loop (DSOGI-FLL), it can obtain accurate current polarities even in harmonic and unbalanced conditions. A DSOGI-FLL-based dead-time elimination PWM is, therefore, proposed in this paper, and several improvements are made to minimize the current zero-crossing distortion. An underlap period is added when alternating the upper and lower drive pulses to smooth the current jump at zero crossing, and a delay compensation term is inserted in the DSOGI-FLL to compensate both the current measurement delay and the control delay. The effectiveness of the proposed DSOGI-FLL-based dead-time elimination PWM has been validated by experiments, respectively, in the unbalanced-current, power-change, and frequency-variation conditions with an RL load, as well as in a grid-connected converter.
Discordance in diagnosis of osteoporosis by quantitative computed tomography and dual-energy X-ray absorptiometry in Chinese elderly men (2018)

This study investigated the diagnostic discordance of osteoporosis by quantitative computed tomography (QCT) and dual-energy X-ray absorptiometry (DXA) in Chinese elderly men. The results demonstrated that QCT is a more sensitive method of choice to identify osteoporosis in elderly Chinese men. This work may help clinicians make an appropriate choice of technique for the accurate diagnosis of osteoporosis and identify the patients at high risk of osteoporosis who should be treated early to prevent fractures. This may influence the therapeutic plan and the overall prognosis of patients.
Quantification of Toxic Microcystis spp. during the 2003 and 2004 Blooms in Western Lake Erie using Quantitative Real-Time PCR (2005)

In August of 2003 and August of 2004, blooms of potentially toxic cyanobacteria Microcystis spp. persisted in western Lake Erie. Samples collected from the bloom were analyzed for the cyanobacterial toxin microcystin and the presence of Microcystis spp. cells. Estimates of microcystin toxicity exceeding 1 microg L(-1) (microcystin-LR activity equivalents), the safety limit set by the World Health Organization, were found from the samples in both 2003 and 2004. The presence of Microcystis spp. in water samples was confirmed through standard polymerase chain reaction (PCR) using a combination of four primer sets. Quantification of Microcystis was accomplished by a real-time PCR assay utilizing specific primer-Taq-man probe sets targeted on a conserved, Microcystis-specific 16S rDNA fragment and a microcystin toxin synthetase gene mcyD. This approach allowed us to specifically study the distribution and abundance of toxic Microcystis in the lake in contrast to previous studies that have assessed Microcystis populations with less refined methods. On the basis of quantification by quantitative real-time PCR analysis, the total abundance of Microcystis cells in the bloom area varied from 4 x 10(8) to 2 x 10(3) cells L(-1). The results of this study provide novel insight regarding the distribution and abundance of Microcystis spp. in the western basin of Lake Erie, a region plagued in recent years by large-scale (>20 km2) blooms. Our results suggest that the Maumee River and Bay may serve as a source for Microcystis to western and central Lake Erie.
Commande des composants à semi-conducteurs de puissance : contexte (2017)

International audience
Keratosis Pilaris Rubra (2006)

Keratosis pilaris rubra is a variant of keratosis pilaris, with more prominent erythema and with more widespread areas of skin involvement in some cases, but without the atrophy or hyperpigmentation noted in certain keratosis pilaris variants. It seems to be a relatively common but uncommonly reported condition.
Controlled Manipulation and in Situ Mechanical Measurement of Single Co Nanowire with a Laser-Induced Cavitation Bubble (2010)

The flow induced by a single laser-induced cavitation bubble is used to manipulate individual Co nanowires. The short-lived (<20 μs) bubble with a maximum size of 45 μm is created in an aqueous solution with a laser pulse. Translation, rotation, and radial motion of the nanowire can be selectively achieved by varying the initial distance and orientation of the bubble with respect to the nanowire. Depending on the initial distance, the nanowire can be either pushed away or pulled toward the laser focus. No translation is observed for a distance further than approximately 60 μm, while at closer distance, the nanowire can be bent as a result of the fast flow induced during the bubble collapse. Studying the dynamics of the shape recovery allows an estimation of the Young's modulus of the nanowire. The low measured Young's modulus (in a range from 9.6 to 13.0 GPa) of the Co nanowire is attributed to a softening effect due to structural defects and surface oxidation layer. Our study suggests that this bubble-based technique allows selectively transporting, orienting, and probing individual nanowires and may be exploited for constructing functional nanodevices.
Electronic Conduction in the Chiral Nematic Phase of an Oligothiophene Derivative (2006)

Carrier transport characteristics in the chiral nematic phase of 2-[5-(4-[(S)-2-methylbutoxy]phenyl)-3-methyl]-2′′′-propyl-2:5′-2′:5′′-2′′:5′′′-quaterthiophene, a liquid-crystalline semiconductor (see picture), are determined with a time-of-flight technique. A non-dispersive transient photocurrent is observed in the chiral nematic phase which is attributed to an electronic processes. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2267/2006/z500712_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Synthesis and structural characterization of the first examples of molecular aggregates of barium supported by aryloxide and alkoxide ligands: [HBa5(O)(OPh)9(thf)8] and [H3Ba6(O)(OBut)11(OCEt2CH2O)(thf)3](thf = tetrahydrofuran) (1990)

The reaction of barium granules in tetrahydrofuran with either phenol or t-butyl alcohol yields phenoxide and t-butoxide aggregates that have been characterized in the crystalline state; they share a number of novel structural features, including the presence of a square-based pyramidal core Ba5(µ5-O) supported by µ3 and µ2 phenoxide or butoxide ligands.
Spermatozoon Counts in Males and Inseminated Queens of the Imported Fire Ants, Solenopsis invicta and Solenopsis richteri (Hymenoptera: Formicidae) (1985)

B. Michael Glancey, Clifford S. Lofgren, Spermatozoon Counts in Males and Inseminated Queens of the Imported Fire Ants, Solenopsis invicta and Solenopsis richteri (Hymenoptera: Formicidae), The Florida Entomologist, Vol. 68, No. 1 (Mar., 1985), pp. 162-168