gebhart/patrepeval huggingface dataset:
Unidirectional acoustic probe based on the particle velocity gradient (2016)

This paper presents the foundations of a unidirectional acoustic probe based on the particle velocity gradient. Highly directional characteristics play a key role in reducing the influence of undesired acoustic sources. These characteristics can be achieved by using multiple acoustic sensors in a spatial gradient arrangement. Two particle velocity sensors possessing the figure eight directivity pattern were used in a first-order gradient configuration to yield a unidirectional probe that can reject most excitations originating from both sides and the rear. The effects of key parameters are thoroughly discussed, and the proposed theory is validated in practice.
Penicillinase-Producing Plasmid Types in Neisseria gonorrhoeae Clinical Isolates from Australia (2014)

Penicillinase-producing Neisseria gonorrhoeae (PPNG) carrying the blaTEM-135 gene is of particular concern, as it is considered a stepping stone toward resistance to extended-spectrum cephalosporins. Here, we sought to characterize plasmid types and the occurrence of the blaTEM-135 gene for N. gonorrhoeae clinical isolates from Australia. We found that blaTEM-135 was prevalent in Australian PPNG and was detected on all three major plasmid types.
Systematic Analysis of the Impact of Diagnostic Delay on Bowel Damage in Paediatric Versus Adult Onset Crohn’s Disease (2019)

Adult CD patients have longer diagnostic delay compared with paediatric CD patients and present at diagnosis more often with bowel stenosis and surgery. Length of diagnostic delay was found to be predictive for CD-related complications only in the adult but not in the paediatric CD population.
Nitrogen reflow ovens: the effect exit temperature has on benzotriazole coated copper boards (2002)

Reports on the comparisons made of three nitrogen capable ovens. The ovens range in size and price representative of common market offerings. The ovens compared were forced convection type and oxygen concentrations (02 ppm) were set at comparable levels. All of the ovens have some exit cooling capability (nitrogen contained). Cards exiting the oven may be oxidized to different levels, dependent on the card's temperature. The level of oxidation sustained on the card's second side due to the first reflow operation and/or any intermediate process steps, e.g., misprinted paste strips, should be known. Downstream solderability and/or processability operations may be affected. Results from this work were used to provide process engineering a quantifiable way of making capital expense decisions.
Antigen targeted to the apoptotic pathway via dying erythrocytes leads to profound T cell exhaustion and tolerance (2020)

Abstract The current standard of care for autoimmune disease is administration of immunosuppressive agents that require a lifetime of treatment and leave patients susceptible to opportunistic infections. Thus, there is a great need for therapies that induce lasting and antigen-specific tolerance, which would require fewer treatments and allow the immune system to fully respond to pathogens. A promising target for the induction of antigen-specific tolerance is the apoptotic pathway. Antigen-presenting cells create a tolerogenic milieu upon recognition of apoptotic debris, and antigen presentation by APCs to T cells in the absence of inflammatory cues typically leads to anergy and deletion. A large source of endogenous apoptotic cells is erythrocytes, or red blood cells. The purpose of this study is to discover antibody fragments (Fabs) that bind erythrocytes, and use these Fabs to deliver antigen to erythrocytes for processing via the apoptotic pathway and presentation to T cells for tolerance. Phage display on mouse erythrocytes yielded high affinity Fabs that lacked binding to peripheral blood mononuclear cells and induced no hematological changes. Erythrocyte-binding Fabs were recombinantly expressed with the model antigen ovalbumin and administered to mice. Targeting ovalbumin to erythrocytes led to robust abortive proliferation of antigen-specific T cells. Remaining cells appeared phenotypically exhausted, and had reduced capacity to produce inflammatory cytokines upon restimulation. Antigen presentation of erythrocyte-targeted antigen occurred in the spleen, because T cell exhaustion was completely reversed in splenectomized mice. Thus, targeting erythrocytes may induce lasting antigen-specific tolerance.
Developments on Immunoassays for Pyrethroid Chemicals (2018)

Pyrethroids exist in numerous commercial insecticide formulations and have been used extensively all over the globe for pest control indoors and outdoors in many fields such as agriculture, public health, home use, and veterinary applications. The use of pyrethroids has increased continuously in recent years. This review aims to provide the latest research progress on newly developed haptens and antibodies, as well as their main applications in monitoring pyrethroid residues in the medical, environmental and agricultural fields. Two types of haptens were designed for pyrethroid insecticides. One recognized only a specific pyrethroid insecticide, whereas the other detected a series of pyrethroid insecticides with common molecular structures. Haptens and their conjugates were prepared to produce either monoclonal or polyclonal antibodies. The literature reviews have shown that a major trend for using enzyme immunoassay (EIA) methods to detect pyrethroid pesticide residues is to design universal immune haptens and prepare selective broad-spectrum antibodies. Besides, to develop immune detection methods for pyrethroid residues is an important research and development topic for monitoring the quality and safety of agricultural products worldwide. Keywords: Pyrethroid chemicals, hapten, antibody, immunoassay, medical fields, environmental and agricultural fields.
Synthesis of Antimitotic Analogs of the Microtubule Stabilizing Sponge Alkaloid Ceratamine A (2008)

Antimitotic analogs of the microtubule stabilizing sponge alkaloid ceratamine A (1) have been synthesized starting from tribromoimidazole. A key step in the synthesis is the formation of the azepine ring via an intramolecular Buchwald coupling between a vinyl bromide and a N-methyl amide. This represents the first synthesis of a fully unsaturated imidazo[4,5,d]azepine. NMR data obtained for the synthetic ceratamine analogs has provided support for the structure assigned to the natural product.
Photocatalytic Activity of Cellulose Acetate Nanoceria/Pt Hybrid Mats Driven by Visible Light Irradiation (2021)

A photocatalytic system for the degradation of aqueous organic pollutants under visible light irradiation is obtained by an innovative approach based on ceria/platinum (Pt) hybrid nanoclusters on cellulose acetate fibrous membranes. The catalytic materials are fabricated by supersonic beam deposition of Pt nanoclusters directly on the surface of electrospun cellulose acetate fibrous mats, pre-loaded with a cerium salt precursor that is transformed into ceria nanoparticles directly in the solid mats by a simple thermal treatment. The presence of Pt enhances the oxygen vacancies on the surface of the formed ceria nanoparticles and reduces their band gap, resulting in a significant improvement of the photocatalytic performance of the composite mats under visible light irradiation. Upon the appropriate pretreatment and visible light irradiation, we prove that the most efficient mats, with both ceria nanoparticles and Pt nanoclusters, present a degradation efficiency of methylene blue of 70% and a photodegradation rate improved by about five times compared to the ceria loaded samples, without Pt. The present results bring a significant improvement of the photocatalytic performance of polymeric nanocomposite fibrous systems under visible light irradiation, for efficient wastewater treatment applications.
Lenalidomide Plus Low-Dose Dexamethasone (Ld): Superior One and Two Year Survival Regardless of Age Compared to Lenalidomide Plus High-Dose Dexamethasone (LD) (2010)

Abstract Abstract 308 Introduction: The Eastern Cooperative Oncology Group (ECOG) has previously reported the superior 1 and 2 year survival of Ld versus LD as initial therapy in newly diagnosed symptomatic multiple myeloma (MM) (Rajkumar et al Lancet Oncol 2010; 11: 29–37). The 1 year and 2 year OS for Ld vs LD were 96% and 85% vs 88% and 78%, (p &lt; 0.01), respectively. This despite higher ORR in LD vs Ld (79% vs 68%; p = 0.008). The difference in OS was predominantly due to early death in the LD group (5% vs 0.5%; p = 0.003). As a result of this analysis, Ld is now considered the standard of care. However, it should be noted that the majority of these deaths occurred in pts &gt; 65. In this analysis, we evaluated the impact of age on dexamethasone dose intensity and OS. Methods: 445 pts were randomly assigned: 223 to LD and 222 to Ld. Pts were analyzed on an intent-to-treat basis for OS. The pts were analyzed by age in 2 groups: &lt; 65 and &gt; 65 (the age corresponding to transplant eligibility outside the US). The pts &gt; 65 were then further subdivided into &gt;70 and &gt; 75 yrs. Results are expressed as OS probability at 1 and 2 years post randomization. In addition, to eliminate the early death ‘penalty’ in the LD group in the original analysis, a landmark analysis was performed at 4 months. Results: Overall Survival Probability: Intent-to Treat Analysis Overall Survival Probability: 4 month Landmark Analysis Conclusions: As previously reported, OS in the trial at 1 and 2 years was superior with Ld. OS was not superior with LD compared with Ld in any age group despite a higher response rate. This was true even when using a landmark analysis to eliminate the 5% early deaths seen in the first 4 months of treatment. We conclude the following: 1) LD is not definitively superior to Ld in any age group; 2) Given the higher toxicity in the absence of a clear survival benefit with LD, Ld remains the best choice for all ages. This analysis confirms the original opinion that low-dose dexamethasone is the standard of care for all newly diagnosed MM pts, regardless of age. Disclosures: Vesole: Millennium Pharmaceuticals: Speakers Bureau; Celgene: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Centorcor-Ortho-Biotech: Speakers Bureau. Off Label Use: Lenalidomide for front-line therapy in multiple myeloma. Abonour:Celgene: Speakers Bureau; Millennium Pharmaceuticals: Speakers Bureau. Callander:Millennium Pharmaceuticals: Research Funding. Fonseca:Amgen: Consultancy; Bristol-Myers Squibb: Consultancy; Celgene: Consultancy, Research Funding; Genzyme: Consultancy; Onyx: Research Funding; Otsuka: Consultancy; Medtronic: Consultancy; Intellikine: Consultancy. Siegel:Celgene: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Millennium Pharmaceuticals: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Merck: Membership on an entity's Board of Directors or advisory committees.
MUSCULAR STRENGTH ACROSS THE ADULT LIFE SPAN IS INFLUENCED BY INSULIN-LIKE GROWTH FACTOR-2 (IGF2) GENOTYPE. (2002)

PURPOSE: To determine if IGF2 genotype is related to muscle strength across the adult age span. METHODS: 523 healthy men and women (20–90 yr) were evaluated repeatedly at approximately 2-year intervals as part of the Baltimore Longitudinal Study of Aging (BLSA). Since IGF2 is imprinted and only the paternal allele is expressed, only individuals homozygous for either the G allele (G/G; n = 255) or the A allele (A/A; n = 65) were compared in order to study the influence of each allele on arm strength. Arm strength was assessed by the sum of four components along the axis of both forearms and bilateral grip using a hand dynamometer (1960–1985; follow-up = 10.8 ± 6.5 yr) and by measurement of isokinetic peak torque of the elbow flexors and extensors using a Kin-Com isokinetic dynamometer at a velocity of 0.79 rad/sec (1992–2001; follow-up = 4.06 ± 1.78 yr). Mixed effects models were used to analyze if IGF2 genotype was associated with each type of arm strength, and whether an interaction was present between IGF2 genotype and age at baseline measurement (cross-sectional component) and between IGF2 genotype and length of time enrolled in the study (longitudinal component). RESULTS: Though the interaction effects were not significant for either strength measure, a significant (P < 0.05) effect of IGF2 genotype was found for isokinetic arm strength for all observations, such that G/G homozygotes demonstrated 7.0% greater isokinetic strength vs. A/A homozygotes (126.0 ± 2.9 Nm vs. 117.7 ± 1.6 Nm) when adjusting for gender, height, weight and activity level (MET*min/day). No significant effect was found for IGF2 genotype on isometric strength. CONCLUSION: The results indicate that the IGF2 allele is associated with greater isokinetic concentric arm strength across the adult age span. Supported by NIA's Intramural Research Program, AG16205 and AG05893
Arranging touch screen software keyboard split-keys based on contact surface (2010)

Touch screen devices, which have become ubiquitous in our daily lives, offer users flexible input and output operations. Typical operation methods for touch screen devices include the use of a stylus or a finger. A touch screen user can select a stylus or finger depending on the user's situation and preference. In this paper, we propose a dynamic method of assigning symbols to keys for a software keyboard on a touch screen device. This method provides flexible adjustment to both the stylus operation and finger operation.
High-performance n-type field-effect transistors based on a highly crystalline tricyanovinyldihydrofuran derivative (2016)

We propose a novel tricyanovinyldihydrofuran (TCF)-based molecule called DBOB-DTCF that is designed and synthesized for application in n-type field-effect transistors (FETs). It can be operated in a stable manner under ambient conditions. DBOB-DTCF is successfully fabricated as crystalline microplates (CMs) because of its capability of self-assembly. A high electron mobility of ∼1.9 cm<sup>2</sup> V<sup>-1</sup> s<sup>-1</sup> is observed for a CM-based FET, measured under ambient conditions. This suggests that TCF is an excellent acceptor unit that organizes air stable n-type organic semiconductors.
Penibruguieramine A, a Novel Pyrrolizidine Alkaloid from the Endophytic Fungus Penicillium sp. GD6 Associated with Chinese Mangrove Bruguiera gymnorrhiza (2014)

A novel pyrrolizidine alkaloid, penibruguieramine A (1), characterized by an unprecedented 1-alkenyl-2-methyl-8-hydroxymethylpyrrolizidin-3-one skeleton, was isolated from the endophytic fungus Penicillium sp. GD6, associated with the Chinese mangrove Bruguiera gymnorrhiza. The absolute configuration of penibruguieramine A (1) was established by TDDFT ECD calculations of the vacuum and solution conformers, exploiting the transitions of the lactam chromophore. A plausible pathway for its biosynthesis has been proposed.
Holographic Superfluids and the Dynamics of Symmetry Breaking (2013)

We explore the far-from-equilibrium response of a holographic superfluid using the AdS/CFT correspondence. We establish the dynamical phase diagram corresponding to quantum quenches of the order parameter source field. We find three distinct regimes of behavior that are related to the spectrum of black hole quasinormal modes. These correspond to damped oscillations of the order parameter and to overdamped approaches to the superfluid and normal states. The presence of three regimes, which includes an emergent dynamical temperature scale, is argued to occur more generally in time-reversal-invariant systems that display continuous symmetry breaking.
Antioxidant activity of faba bean extract and fractions thereof (2018)

Phenolic compounds were extracted into 80% (v/v) acetone. The crude extract so obtained was separated into fraction of low-molecular-weight compounds (Fraction I) and a fraction of condensed tannins (Fraction II) using Sephadex LH-20 column chromatography with ethanol and acetone/water (1:1, v/v) as respective mobile phases. The antioxidants activities of the crude extract and fractions thereof was investigated in an emulsion system and using ABTS, DPPH, and reducing power assays. Fraction II exhibited a higher antioxidant efficacy than those of the crude extract and Fraction I. In the crude extract, 21 compounds, namely phenolic acids (gallic, p-hydroxybenzoic, protocatechuic , p-coumaric, ferulic), flavonoids (catechin, epigallo catechin, kaempferol, apigenin, and luteolin derivatives), gallate procyanidins, vanillin, protocatechuic aldehyde, and tryptophan were identified by HPLCDAD- MS. Gallate procyanidin dimer, gallate procyanidins, and acetylated kaempferol hexose were the major phenolics present in the extract.
Frontiers in Medicinal Chemistry in Regensburg (2008)

A meeting of innovation: The scenic college town of Regensburg in eastern Bavaria hosted a meeting of scientists working in GPCR research, antiviral drugs, cardiovascular and metabolic diseases, and molecular imaging. Conference highlights are discussed.
MicroRNA-23a-3p influences the molecular mechanism of gastric cancer cells via CCL22/PI3K/Akt axis (2021)

A great many microRNAs (miRNAs) have been reported to play different roles in human cancers, including gastric cancer (GC). However, the specific character of miR-23a-3p in GC has not been elucidated. This study was to explore the function of miR-23a-3p in GC. The results manifested that miR-23a-3p was down-regulated in GC and patients with reduced miR-23a-3p had poor prognosis. Functional experiments assured that elevated miR-23a-3p refrained GC proliferation, invasion, migration, PIK3/Akt phosphorylation and apoptosis, while knockdown miR-23a-3p accelerated the growth of GC. Double luciferase report experiments manifested that miR-23a-3p targeted CCL22 expression. Functional rescue experiments affirmed that the repression of elevated miR-23a-3p on GC was reversed by simultaneous augmented CCL22. <i>In vivo</i>, elevated miR-23a-3p restrained the volume and tumor of GC and reduced the expression of CCL22 and phosphorylated PIK3/Akt, while knockdown miR-23a-3p motivated tumor growth. In conclusion, the results of this study indicate that miR-23a-3p plays a repressive role in GC, and affects the progression of GC via down-regulating CCL22 and blocking PI3K/AKT signal transduction pathway, which may offer a new molecular target for clinical treatment of GC.
Abundant transposases encoded by the metagenome of a hydrothermal chimney biofilm (2009)

The carbonate chimneys of the Lost City Hydrothermal Field on the Mid-Atlantic Ridge are coated in thick microbial biofilms consisting of just a few dominant species. We report a preliminary analysis of a biofilm metagenome that revealed a remarkable abundance and diversity of genes potentially involved in lateral gene transfer (LGT). More than 8% of all metagenomic reads showed significant sequence similarity to transposases; all available metagenomic data sets from other environments contained at least an order of magnitude fewer transposases. Furthermore, the sequence diversity of transposase genes in the biofilm was much greater than that of 16S rRNA genes. The small size and high sequencing coverage of contigs containing transposases indicate that they are located on small but abundant extragenomic molecules. These results suggest that rampant LGT among members of the Lost City biofilm may serve as a generator of phenotypic diversity in a community with very low organismal diversity.
Differential Expression of Matrix Metalloproteinase-2 Expression in Disseminated Tumor Cells and Micrometastasis in Bone Marrow of Patients with Nonmetastatic and Metastatic Prostate Cancer: Theoretical Considerations and Clinical Implications—An Immunocytochemical Study (2012)

Matrix metalloproteinase-2 (MMP-2) is important in the dissemination and invasion of tumor cells and activates angiogenesis. We present an immunocytochemical study of MMP-2 expression in circulating prostate cells (CPCs), disseminated tumor cells (DTCs), and micrometastasis (mM) in bone marrow of men with prostate cancer. Methods and Patients. Tumor cells were identified with anti-PSA immunocytochemistry. Positive samples underwent processing with anti-MMP-2, its expression was compared with Gleason score, concordance of expression, and metastatic and nonmetastatic disease. Results. 215 men participated, CPCs were detected in 62.7%, DTCs in 62.2%, and mM in 71.4% in nonmetastatic cancer; in metastatic cancer all had CPCs, DTCs, and mM detected. All CPCs and DTCs expressed MMP-2; in mM MMP-2 expression was positively associated with increasing Gleason score. MMP-2 expression in CPCs and DTCs showed concordance. In low grade tumors, mM and surrounding stromal cells were MMP-2 negative, with variable expression in high grade tumors; in metastatic disease, both mM and stromal cells were MMP-2 positive. Conclusions. CPCs and DTCs are different from mM, with inhibition of MMP-2 expression in mM of low grade tumors. With disease progression, MMP-2 expression increases in both mM and surrounding stromal cells, with implications for the use of bisphosphonates or MMP-2 inhibitors.
Outcomes of autologous bone marrow mononuclear cell administration in the treatment of neurologic sequelae in children with spina bifida (2023)

gov/ct2/show/NCT05472428 .
Measurements and Analysis of an In-Car UWB Channel (2008)

Car manufacturers have been showing great interest in setting up ultra-wideband (UWB) systems due to the offered high data rates. In this paper, the fundamental features of the in-car UWB channel in terms of large-scale and small-scale parameters are investigated. These values are based on measurement data collected with a vector network analyzer (VNA) in the frequency band of 3-8 GHz. With the aid of the measurements, simple preliminary empirical models have been derived describing both, path loss as well as small-scale features of the channel. The results are shown for LOS and NLOS situations as well as for an empty car and a car occupied with persons.
An EMG-to-Force Processing Approach for Estimating in Vivo Hip Muscle Forces in Normal Human Walking (2016)

The force of a single muscle is not directly measurable without invasive methods. Yet invasive techniques are not appropriate for clinical use, thus a non-invasive technique that combined the electromyographic (EMG) signal and a neuromuscular model was developed to determine in vivo active muscle forces at the hip. The EMG-to-force processing (EFP) model included active and passive moment components, and the net EFP moment was compared with the hip moment obtained with standard inverse dynamics techniques ("gold standard"). The two methods were compared at percent gait cycle intervals, and the correlation coefficient between methods was excellent (r2=91). The closeness of fit confirms that the approach is a reasonable approximation of net moment and, possibly, individual muscle forces. The greatest estimated hip force was produced by a hip abductor. A novel finding was that the hip adductors did not behave a single synergistic group. The Adductor Magnus synergistically assisted other hip extensors, and produced forces that were out-of-phase with the other hip adductor forces. Rectus Femoris was only active during hip flexion (not knee extension).