gebhart/patrepeval huggingface dataset:
Apparatus and method for oxidizing organic materials (2023)

The invention is a method and apparatus using high cerium concentration in the anolyte of an electrochemical cell to oxidize organic materials. The method and apparatus further use an ultrasonic mixer to enhance the oxidation rate of the organic material in the electrochemical cell.
Synthesis and applications of a new class of phosphorus donor ligands for asymmetric catalysis (1997)

The synthesis and applications to allylic substitutions of a range of novel ligands based on diazaphospholidines is described; enantiomeric excesses of up to 89% were achieved in an allylic substitution reaction.
Analysis of Phonon Structures in the Tunneling Conductance of Bi-Cuprates (1993)

Following a short summary of our tunneling results for Bi 2 Sr 2 Ca n -1 Cu n O y (Bi22( n -1) n ) ( n =1–3), the tunneling phonon structures of Bi2212 are analyzed according to the Eliashberg scheme assuming a certain normal-state conductivity. The McMillan-Rowell spectral function is similar to a model spectral function in which only the Cu–O vibrations are taken into account and the interaction strength is assumed to increase with decreasing frequency. To ascertain whether excitation other than that of phonons contributes to pair formation, we calculated the tunneling conductance for various composite spectral functions. As far as we could discover, the phonon-only spectral function is the function which best explains the tunneling results.
Dissecting the contribution of single nucleotide polymorphisms in CCR9 and CCL25 genomic regions to the celiac disease phenotype (2021)

We conclude that SNPs in the region of <i>CCR9</i> and <i>CCL25</i> with predicted functional effect or exonic localization likely contribute only modestly to various celiac disease phenotypes.
ChemInform Abstract: TRISHOMOCUBANONE (PENTACYCLO(6,3,0,0(2,6),0(3,10),0(5,9))UNDECAN‐4‐ONE) (1975)

Abstract Ausgehend von dem tricyclischen ‐Diketon (I) erhält man über die Verbindungen (II)‐(V) Trishomocubanon (VI).
Legionella species, serogroups and subgroups found in the environment in Singapore. (1989)

Over a period of seven months, 87 samples of water collected from 48 air-conditioning cooling-towers on 15 sites in Singapore yielded 19 strains of Legionella. Legionellas were found in 7 of the 15 sites. The strains isolated fell into 7 species, serogroups or subgroups of the genus Legionella. Only 11% of them belonged to the more pathogenic Pontiac subgroup of Legionella pneumophila serogroup 1.
Regional gene therapy for full‐thickness articular cartilage lesions using naked DNA with a collagen matrix (2006)

A novel gene therapy approach for treating damaged cartilage is proposed that involves placing endotoxin-free cDNA containing the gene for bone morphogenetic protein-2 (BMP-2) in type I collagen sponges and then transferring the naked plasmid DNA construct to the injury site. A full-thickness cartilaginous defect in rabbits implanted with plasmid containing a marker gene (beta-galactosidase) showed expressed protein as detected by immunostaining. At 1 week postimplantation, mesenchymal cells subjacent to the defect had incorporated the implanted naked plasmid DNA and, once transfected, served as local bioreactors, transiently producing the gene product. Plasmids containing the gene for BMP-2 implanted in collagen sponges in cartilage lesions stimulated hyalinelike articular cartilage repair at 12 weeks postimplantation, nearly equivalent in quality to that induced by collagen sponges with recombinant BMP-2 protein. Our approach circumvents the risks of inflammation and immunogenic response associated with the use of viral vectors. Naked plasmid DNA as a vehicle for transferring therapeutic genes has been shown to be effective in a therapeutic model within rabbit articular cartilage and appears to be safe and cost effective.
Hormone activities and the cell cycle machinery in immunity-triggered growth inhibition (2015)

Biotic stress and diseases caused by pathogen attack pose threats in crop production and significantly reduce crop yields. Enhancing immunity against pathogens is therefore of outstanding importance in crop breeding. However, this must be balanced, as immune activation inhibits plant growth. This immunity-coupled growth trade-off does not support resistance but is postulated to reflect the reallocation of resources to drive immunity. There is, however, increasing evidence that growth-immunity trade-offs are based on the reconfiguration of hormone pathways, shared by growth and immunity signalling. Studies in roots revealed the role of hormones in orchestrating growth across different cell types, with some hormones showing a defined cell type-specific activity. This is apparently highly relevant for the regulation of the cell cycle machinery and might be part of the growth-immunity cross-talk. Since plants are constantly exposed to Immuno-activating microbes under agricultural conditions, the transition from a growth to an immunity operating mode can significantly reduce crop yield and can conflict our efforts to generate next-generation crops with improved yield under climate change conditions. By focusing on roots, we outline the current knowledge of hormone signalling on the cell cycle machinery to explain growth trade-offs induced by immunity. By referring to abiotic stress studies, we further introduce how root cell type-specific hormone activities might contribute to growth under immunity and discuss the feasibility of uncoupling the growth-immunity cross-talk.
trans Lipids: The Free Radical Path (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
[The "Journal de Pharmacie et de Chimie" and the two world wars]. (2011)

The "Journal de Pharmacie et de Chimie" was the official publication of the Société de Pharmacie de Paris which became later on the French Academy of pharmacy. It is consequently the organ that presented scientific publications and independent position papers from pharmacists being part of this assembly and coming from universities, drugstores or pharmaceutical industries. We have analyzed the content of this journal during the last two world wars in order to evaluate to what extent the members of the Société de Pharmacie de Paris were part of the war efforts, and encouraged or criticized the on-going events. We can observe that, in both cases, pharmacists used their expert opinions to better react and manage consequences of the conflicts, but also to express their disagreement with enemy's opinions or actions, the Society doing everything possible to maintain its activities. One can observe also that both conflicts were an opportunity to reconsider the organization of pharmacy in France, especially during the Second World War where took place discussions on pharmacy reform (1941 law) and creation of the Pharmacists' Order which will ultimately occur after the war end.
Genetic characterization of the HIV-1 reservoir after Vacc-4x and romidepsin therapy in HIV-1-infected individuals (2018)

We detected no evidence of selective immune pressure reflected in proviral diversity or by occurrence of specific mutation in the vaccine-targeted epitopes. Preexisting CTL epitope mutations may affect the potency of this therapeutic vaccine. This highlights the challenges of developing effective HIV-1 therapeutic vaccines.
Fine particulate air pollution and neuropathology markers of Alzheimer’s disease in donors with and without APOE ε4 alleles – results from an autopsy cohort (2023)

Our study found traffic-related PM<sub>2.5</sub> exposure was associated with CERAD score in an autopsy cohort, contributing to epidemiologic evidence that PM<sub>2.5</sub> affects Aβ deposition in the brain. This association was particularly strong among donors without <i>APOE ε4</i> alleles. Future studies should further investigate the biological mechanisms behind this assocation.
Information-theoretic caching (2015)

Motivated by the caching problem introduced by Maddah-Ali and Niesen, a problem of distributed source coding with side information is formulated, which captures a distinct interesting aspect of caching. For the single-user case, a single-letter characterization of the optimal rate region is presented. For the cases where the source is composed of either independent or nested components, the exact optimal rate regions are found and some intuitive caching strategies are confirmed to be optimal. When the components are arbitrarily correlated with uniform requests, the optimal caching strategy is found to be closely related to total correlation and Wyner's common information. For the two-user case, some subproblems are solved which draw connections to the Gray-Wyner system and distributed successive refinement. Finally, inner and outer bounds are given for the case of two private caches with a common update.
Portable Cloud Services Using TOSCA (2012)

For cloud services to be portable, their management must also be portable to the targeted environment, as must the application components themselves. Here, the authors show how plans in the Topology and Orchestration Specification for Cloud Applications (TOSCA) can enable portability of these operational aspects.
Adult Emergence Profiles of the Oak Leaf Roller Archips semiferanus1 and Its Pupal Parasites2 (1974)

Over 11,000 microlepidoptera pupae were randomly collected over a one week period in June 1972 from a mixed oak forest in central Pennsylvania. Of the adults emerging (58.87%), 98.67% were Archips semiferanus (Walker). Males emerged earlier than females; a sex ratio of 1.22 ♂:1 ♀ was found. Six Hymenoptera pupal parasites were observed, with Itoplectis conquisitor (Say) (3.52%) and Phaeogenes gilvilabris Allen (2.62%) the most common. A. semiferanus is the 1st reported host for P. gilvilabris. The male parasites emerged earlier than the females with the following sex ratio: I. conquisitor, 2.10 ♂:1 ♀; P. gilvilabris, 3.70 ♂: 1 ♀. In general male Hymenoptera parasites emerged from male A. semiferanus pupae, and female parasites from female hosts.
Generation of millimetre and sub-millimetre waves by photomixing in 1.55 µm wavelength photodiode (2002)

A 70 GHz bandwidth commercial photodiode has been used to create a photomixer source of radiation at frequencies from 70 GHz to above 600 GHz. The waveguide source is driven by two 1.55 µm lasers and delivers a peak, nonsaturated, power of −7.5 dBm at 110 GHz with a power conversion efficiency above 1%. Detected power decreases approximately as 1/(frequency)4 above 150 GHz.
Table S3 from Genomic and Transcriptomic Characteristics of Metastatic Thyroid Cancers with Exceptional Responses to Radioactive Iodine Therapy (2023)

&lt;p&gt;Chromosomal and cytogenetic locations of 505 genes in the MSK-IMPACT panel.&lt;/p&gt;
Three phase slurry reactors (1980)

Abstract This article reviews the major developments in the engineering and design of three‐phase slurry catalytic reactors. A general theoretical analysis for predicting the overall rate of reaction in a slurry reactor for various kinetics is presented, incorporating all the transport effects. Modeling of semi‐batch reactors is discussed and design procedures are indicated. Some major correlations and methods for determining gas‐liquid and liquid‐solid mass transfer coefficients and effective diffusivity in liquid filled pores are reviewed. Slurry reactors are compared with other three‐phase reactors, such as trickle bed or packed bed reactors, and relative merits are pointed out.
"250 kWt Pilot Testing in Support of a 10 MWe Coal-Direct Chemical Looping Demonstration Feasibility Study (2019)

The Babcock & Wilcox Company and The Ohio State University are developing iron-based metal oxide chemical looping technology for power generation and conversion of fossil fuels to chemicals and liquid fuels. A 250 kWt pilot facility has been constructed at the Babcock & Wilcox Research Center in Barberton, Ohio. Testing was conducted on the facility to support scale-up of the technology for implementation in a 10 MWe coal direct chemical looping large pilot plant at Dover Light & Power in Dover, Ohio. The paper discusses the results of the pilot test and the impact of the results on the design of the large pilot facility.
Mechanisms Involved in Calcium‐Dependent Exocytosisa (1991)

Peer Reviewed
A uniform object model for parallel programming (1988)

This position statement presents a uniform object model of parallel programming that enables use of multiple programming styles, binding parallelism late, and porting programs among a wide variety of architectures. It then argues for concurrent operations on objects, as opposed to mutually exclusive operations on objects, based on orthogonality between encapsulation and concurrency. The final section argues for its relatively novel insistence on uniform control, based on the flexibility it provides the programmer.
Information management for co operative engineering (1999)

In this paper we describe how a set of autonomous computational agents can cooperate in providing coherent management of information in environments where there are many diverse information resources. The agents use models of themselves and of the resources that are local to them. Resource models may be the schemas of databases, frame systems of knowledge bases, or process models of business operations. Models enable the agents and resources to use the appropriate semantics when they interoperate. This is accomplished by specifying the semantics in terms of a common ontology. We discuss the contents of the models, where they come from, and how the agents acquire them. We then describe a set of agents for telecommunication service provisioning and show how the agents use such models to cooperate. Their interactions produce an implementation of relaxed transaction processing. 1 1
Diagnosis of segment delay defects with current sensing (2014)

A novel technique based on the current profile of path segments is presented. Certain current profiles can provide significant insights into the delay characteristics of the segments. They can assist in post-silicon diagnosis for delay defects and also determine shifts in the values of process parameters along the segments. A method to excite such current profiles is presented. Experimental evaluation on benchmark circuits shows the effectiveness of the approach.
[The flow properties of blood and their characterization by hemorheologic methods]. (1989)

In a number of supply disturbances the flow behaviour of blood plays an increasing role in modern therapy concepts. The present paper deals with representing factors, such as haematocrit, aggregation, deformation, which exercise an influence on the complex flow properties of blood under variable conditions. By referring to the example of deformability it is shown how and to what extent different mechanical parameters of individual erythrocytes participate in static or dynamic whole cell deformation. Starting from fundamental quality demands (sensitivity, specificity, value of prediction) to diagnostic measuring technique, haemorheological methods for determining complex flow properties, aggregation and deformation as single phenomena and mechanical properties of individual erythrocytes are presented. Selected examples of application for normal blood, cells altered in vitro or pathological changes measured ex vivo are referred to.
STracking: a free and open-source python library for particle tracking and analysis (2022)

Abstract Summary Analysis of intra and extra cellular dynamic like vesicles transport involves particle tracking algorithms. Designing a particle tracking pipeline is a routine but tedious task. Therefore, particle dynamics analysis is often performed by combining several pieces of software (filtering, detection, tracking…) requiring a lot of manual operations, and therefore leading to poorly reproducible results. A good synergy between particle detector with a tracker is of paramount importance. In addition, a user-friendly interface to control the quality of estimated trajectories is necessary. To address these issues, we developed STracking a python library that allows to combine algorithms into standardized particle tracking pipelines. Availability and Implementation STracking is available as a python library using “pip install” and the source code is publicly available on GitHub ( https://github.com/sylvainprigent/stracking ). A graphical interface is available using two napari plugins: napari-stracking and napari-tracks-reader . These napari plugins can be installed via the napari plugins menu or using “pip install”. The napari plugin source codes are available on GitHub ( https://github.com/sylvainprigent/napari-tracks-reader , https://github.com/sylvainprigent/napari-stracking ). Contact sylvain.prigent@inria.fr , cesar-augusto.valades-cruz@curie.fr
Identificación de proteínas de membrana intestinal de Cylas formicarius ssp. elegantulus con función receptora para la toxina Cry3Aa de Bacillus thuringiensis ssp. tenebrionis (2015)

The use of Bacillus thuringiensis in biological pest control and to obtain insect resistant transgenic plants commonly rely on basic studies of the action mechanism of Cry toxins in the target insects. These studies are combined with toxin insecticide bioassays in Brush Border Membrane Vesicles (BBMVs) obtained from the insects’ epithelial gut tissues. One of the toxins, Cry3Aa from B. thuringiensis ssp. tenebrionis, has shown activity against sweet potato weevil (Cylas formicarius ssp. elegantulus Fabricius), the main pest for this crop. Here is described for the first time the binding capacity of Cry3Aa to BBMVs vesicles obtained from the midgut of second-third instar larvae of this insect. BBMVs were purified and insecticide protein labelling and binding assays performed according to standard procedures. Four proteins (approximately 20, 30, 50 and 85 kDa, respectively) were detected as mediating binding of the CryAa toxin to the insect gut, as putative receptors. Peptides from these proteins were sequenced and aligned for homology detection against database sequences, leading to their identification as previously unreported proteins with this function. Additionally, storage roots from transgenic sweet potato plants expressing high levels of the Cry3Aa toxin were used in an in vivo bioassay to test insect control under lab conditions. The results suggested that the toxic activity of Cry3Aa from B. thuringiensis ssp. tenebrionis against sweet potato weevil could involve the toxin binding to some of the detected proteins in the insect gut.
Current Protocols in Neuroscience (2018)

Current Protocols in Neuroscience (CPN) draws from techniques in molecular neurobiology, neurophysiology, neuroanatomy, neuropharmacology, and behavioral neuroscience to meet the specific needs of researchers in the full range of disciplines that is involved in studying the brain, nervous system, and corresponding behaviors. The editorial board of CPN have assembled an outstanding range of methods to enable users to explore their fields in greater depth and branch into related areas. The one-volume, looseleaf manual features carefully edited techniques with authors' troubleshooting tips and helpful comments that come from extensive experience in using these procedures. Quarterly updates, filed into the looseleaf, keep you and your laboratory current with the latest developments in this rapidly changing field. The initial purchase includes one year of updates and then subscribers may renew their annual subscriptions. Current Protocols publishes a family of laboratory manuals for bioscientists, including Molecular Biology, Immunology, Human Genetics, Protein Science, Cytometry, Cell Biology, Pharmacology, and Toxicology.
Analytical model and behavioral simulation approach for a ΣΔ fractional-N synthesizer employing a sample-hold element (2003)

A previously unknown intrinsic nonlinearity of standard /spl Sigma//spl Delta/ fractional-N synthesizers is identified. A general analytical model for /spl Sigma//spl Delta/ fractional-N phased-locked loops (PLLs) that includes the effect of the nonlinearity is derived and an improvement to the synthesizer topology is discussed. Also, a new methodology for behavioral simulation is presented: the proposed methodology is based on an object-oriented event-driven approach and offers the possibility to perform very fast and accurate simulations, and the theoretical models developed validate the simulation results. We show a GSM example to demonstrate the applicability of the simulation methodology to real study cases.
Comparisons of ATP turnover in human muscle during ischemic and aerobic exercise using 31P magnetic resonance spectroscopy (1994)

To investigate human muscle bioenergetics quantitatively in vivo, we used 31P magnetic resonance spectroscopy to study the flexor digitorum superficialis of four adult males during dynamic ischemic and aerobic exercise at 0.50-1.00 W and during recovery from aerobic exercise. During exercise, changes in pH and [PCr] were larger at higher power, but in aerobic exercise neither end-exercise [ADP] nor the initial postexercise PCr resynthesis rate altered with power. In ischemic exercise we estimated total ATP synthesis from the rates of PCr depletion and glycogenolysis (inferred using an analysis of proton buffering); this was linear with power output. In aerobic exercise, again we estimated ATP synthesis rates due to phosphocreatine hydrolysis and glycogenolysis (incorporating a correction for proton efflux) and also estimated oxidative ATP synthesis by difference, using the total ATP turnover rate established during ischemic exercise. We conclude that in early exercise oxidative ATP synthesis was small, increasing by the end of exercise to a value close (as predicted) to the initial postexercise rate of PCr resynthesis. Furthermore, a plausible estimate of proton efflux during aerobic exercise can be inferred from the pH-dependence of proton efflux in recovery.
Wood Diaphragm Deflections. I: Generalizing Standard Equations Using Mechanics-Based Derivations for Panel Construction (2023)

Horizontal wood diaphragm systems, whether decked with conventional or mass timber panels, transfer wind and seismic loads to vertical elements of a lateral force-resisting system (LFRS), in flexible, rigid, or semirigid fashion. Characterizing and calculating the resulting diaphragm deflections determines the distribution of forces to critically loaded components and a significant portion of lateral building translations and rotations. Deflection equations for sheathed wood structural panel (WSP) diaphragms are well established in US design standards in a four-term expression that models flexural, shear, and fastener-slip deformations, and its full derivation using principles of mechanics is provided herein. Derivations of similar equations for cross-laminated timber (CLT) diaphragms have yet to unfold, despite growing industry consensus that CLT panels make efficient slabs and decks. In this first of two companion papers, the corrected full derivation of the current four-term WSP diaphragm deflection expression is provided and assessed, and two ways to quantify the cumulative contribution of fastener slip are presented to expand its usage to a wider variety of WSP and CLT configurations in current use. Building on this generalized mechanics-based derivation, the authors are able to propose and assess in the companion paper a unified diaphragm deflection model to compute both WSP and CLT diaphragm deflections as implemented under current practice and guide further development.