gebhart/patrepeval huggingface dataset:
Characterization of the Left-Sided Substrate in Arrhythmogenic Right Ventricular Cardiomyopathy (2015)

LV substrate is frequent in arrhythmogenic RV cardiomyopathy, but poorly identified by current diagnostic strategies. Left-sided arrhythmias are more frequent in case of LV involvement. LV fat hosts the same density of local abnormal ventricular activity as RV fat, but is less efficiently detected by voltage mapping. These results support the need for alternative diagnostic strategies to identify LV dysplasia.
Revolutionizing Offshore Production by InLine Separation Technology (2010)

Abstract The separation process is the heart of the offshore production system. Conventional technology requires massive equipment to allow for required separation of oil, gas, water and sand. Most separation equipment is based on gravity separation principles that require larger retention times and low fluid velocities. These separators have over several years been subject to further development by introduction of new separation principles. Advanced separator internals have been an important contributor in this respect. During the last decade, Inline Separation Technology has successfully been introduced to several applications. Inline Separation is separation in pipe segments instead of within large vessels. Especially separation by use of cyclonic forces has been important. Inline technologies for separation of gas and liquid, oil and water as well as sand from liquid and multiphase streams have been developed and are already used extensively in retrofit applications to increase the performance and capacity of existing offshore production systems. As the inline technology matures, total production systems can be developed based on use of inline separation technology. This will allow for substantially more compact and cost efficient field developments. It will also enable new applications, such as heavy oil and deepwater subsea applications, which are not feasible to develop with conventional technology. This paper gives an overview of the inline separation technology and how this technology can be used to make improvements to offshore production system designs.
Ten-Day Sequential Therapy of Helicobacter pylori Infection in Thailand (2009)

The 10-day sequential treatment for H. pylori is well tolerated and provides a high eradication rate. This regimen can overcome the emergence of antibiotic resistance and may have a role as a first-line treatment for H. pylori infection in Thailand.
Effects of cyclodextrins on the hydrolysis of prostacyclin and its methyl ester in aqueous solution. (1981)

The rates of hydrolysis of prostacyclin (PGI2) and its methyl ester (PGI2Me) in aqueous solution were significantly retarded by α-, β-, and γ-cyclodextrins (α-, β-, and γ-CyDs), and showed characteristic saturation kinetics and competitive inhibition. The deceleration effects of CyDs on the hydrolysis of PGI2Me were about 3 times larger than those on the hydrolysis of PGI2. The importance of the spatial relationship between the host and guest molecules was reflected in the kinetically determined stability constant (Kc) for these inclusion complexations. To elucidate the deceleration mechanism of the CyDs, the effects of pH, solvent and temperature on the hydrolysis rate were studied. The protolytic dissociation of the terminal carboxylic acid moiety of PGI2 was suppressed by the binding to CyDs, depending upon the magnitude of the Kc value. Thermodynamic activation parameters suggested that the deceleration mechanism of CyDs in the case of PGI2 was somewhat different from that for PGI2Me, which may be due to different modes of inclusion.
Spatial-domain-based energy-efficient optical communications and networks (2011)

Spatial-domain-based energy-efficient N-dimensional coded-modulation is studied as a high-speed enabling technology for indoor optical wireless communication, terrestrial free-space optical communication and data center applications. The energy-efficient signal constellation is designed by maximizing the mutual information, while imposing the energy constraint.
Shaping current waveforms for direct modulation of semiconductor lasers (2004)

We demonstrate a technique for shaping current inputs for the direct modulation of a semiconductor laser for digital communication. The introduction of shaped current inputs allows for the suppression of relaxation oscillations and the avoidance of dynamical memory in the physical laser device, i.e., the output will not be influenced by previously communicated information. For the example of time-optimized bits, the possible performance enhancement for high data rate communications is shown numerically.
Euclidean Symmetry and Equivariance in Machine Learning (2020)

Understanding symmetry’s role in the physical sciences is critical for choosing an appropriate machine learning method. While invariant models are the most prevalent symmetry-aware models, equivariant models can more faithfully represent physical interactions. Until recently, equivariant models had been absent in the literature due to their technical complexity. Now, after two years of active development, fully-equivariant Euclidean neural net- works are ready to take on challenges across the physical sciences.
Global CF2C12 measurements by UARS cryogenic limb array etalon spectrometer: Validation by correlative data and a model [CF_2C1_2] (1996)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
In vivo, fliC expression by Salmonella enterica serovar Typhimurium is heterogeneous, regulated by ClpX, and anatomically restricted (2006)

FliC is a natural antigen recognized by the innate and adaptive immune systems during Salmonella infection in mice and humans; however, the regulatory mechanisms governing its expression in vivo are incompletely understood. Here, we use flow cytometry to quantify fliC gene expression in single bacteria. In vitro, fliC transcription was not uniformly positive; a viable fliC-negative subpopulation was also identified. Intracellular Salmonella repressed transcription of fliC and its positive regulator fliA, but constitutively transcribed the master regulator flhD; fliC repression required ClpXP protease, known to degrade FlhD. In orally infected mice, fliC transcription was anatomically restricted: Salmonella transcribed fliC in the Peyer's Patches (PP) but not in the mesenteric lymph nodes and spleen. The intracellularly transcribed pagC promoter was upregulated by Salmonella in all tissues, defining the infected PP as a unique environment that initiates expression of intracellularly induced genes and yet permits transcription of fliC. Because a single bacterium can escape the GI tract to colonize deeper tissues, heterogeneous gene expression may have important implications for Salmonella pathogenesis: FliC-positive bacteria in the PP could stimulate inflammation and facilitate the priming of FliC-specific immune responses, while FliC-negative bacteria escape host detection in the gut and spread to systemic sites of replication.
Biological Phosphorus Removal: Impact of the Aerobic Phase on Modeling Continuous-Flow Systems (2009)

Biological Phosphorus Removal: Impact of the Aerobic Phase on Modeling Continuous-Flow SystemsProcess models for enhanced biological phosphorus removal systems are shown to predict anaerobic behavior better than aerobic behavior. Reasons for this include the use of uncalibrated kinetic parameters as well as difficulties introduced by the choice of model structure. A modeling approach is proposed in which model structure and stoichiometric values for both the anaerobic and aerobic phase are...Author(s)Dwight HouwelingYves ComeauImre TakácsPeter DoldSourceProceedings of the Water Environment FederationSubjectSession 1 - Biological Phosphorus RemovalDocument typeConference PaperPublisherWater Environment FederationPrint publication date Jan, 2009ISSN1938-6478SICI1938-6478(20090101)2009:4L.63;1-DOI10.2175/193864709793900979Volume / Issue2009 / 4Content sourceNutrient Removal and Recovery SymposiumFirst / last page(s)63 - 83Copyright2009Word count118Subject keywordsWastewaterEBPRPAOsMetabolic ModelsProcess ModelsPhosphorus
Supplementary Table S1 from ADAPT, a Novel Scaffold Protein-Based Probe for Radionuclide Imaging of Molecular Targets That Are Expressed in Disseminated Cancers (2023)

&lt;p&gt;Affinity constants of DOTA-C-(HE)3-ADAPT6 and H6-ADAPT6.&lt;/p&gt;
Location Tracking and Remote Monitoring system of Home residents using ON/OFF Switches and Sensors (2006)

In this paper, we researched the searching and tracking locations of a home resident using ON/OFF switches and sensors and designed a remote monitoring system. As an implementation environment, this system is developed on the base of the distributed object group framework we have developed from previous works. In order to trace the moving locations of a home resident, we firstly showed a home structure which attaches ON/OFF switches and sensors to home appliances and indoor facilities being fixed in home. Whenever a home resident opens/closes these objects, the signals operated from ON/OFF switches and sensors are sent to a home server system. In this time, the real locations of ON/OFF switches and sensors that the signals are being occurred must be the current location that he/she stays. A home server system provides the functionalities that map the real location of a resident in home to virtual location designed on remote desk-tops or terminals like PDAs, and that construct a healthcare database consisted of moving patterns, moving ranges, momentum for analyzing the given searching locations and times Finally, this system provides these information for remotely monitoring services.
3D Object Proposals using Stereo Imagery for Accurate Object Class Detection (2016)

The goal of this paper is to perform 3D object detection in the context of autonomous driving. Our method first aims at generating a set of high-quality 3D object proposals by exploiting stereo imagery. We formulate the problem as minimizing an energy function that encodes object size priors, placement of objects on the ground plane as well as several depth informed features that reason about free space, point cloud densities and distance to the ground. We then exploit a CNN on top of these proposals to perform object detection. In particular, we employ a convolutional neural net (CNN) that exploits context and depth information to jointly regress to 3D bounding box coordinates and object pose. Our experiments show significant performance gains over existing RGB and RGB-D object proposal methods on the challenging KITTI benchmark. When combined with the CNN, our approach outperforms all existing results in object detection and orientation estimation tasks for all three KITTI object classes. Furthermore, we experiment also with the setting where LIDAR information is available, and show that using both LIDAR and stereo leads to the best result.
Why a Complete Response Is the Treatment Aim in Chronic Spontaneous Urticaria (2023)

This study investigated the association between urticaria activity and health-related quality of life (HRQoL). Patient evaluations from the ligelizumab Phase 2b clinical trial (N = 382) were pooled (NCT02477332). Daily patient diaries assessed urticaria activity, sleep and activity interference, the dermatology life quality index (DLQI), and work productivity and activity impairment-chronic urticaria (WPAI-CU). The number of DLQI scores, weekly sleep interference scores (SIS7), weekly activity interference scores (AIS7), and overall work impairment (OWI) evaluations with a complete response per weekly urticaria activity score (UAS7) using bands (0, 1-6, 7-15, 16-27, and 28-42) were reported. Over 50% of the patients had a mean DLQI of > 10 at baseline, indicating a significant effect of chronic spontaneous urticaria (CSU) on their HRQoL. Complete response (UAS7 = 0) evaluations corresponded with no impacts on other patient-reported outcomes. In total, 91.1% of UAS7 = 0 evaluations corresponded to DLQI scores of 0-1, 99.7% to SIS7 scores of 0, 99.7% to AIS7 scores of 0, and 85.3% to OWI scores of 0. This was significantly different compared with the UAS7 = 1-6 evaluations (61.9%, 68.5%, 67.7%, and 65.4%, respectively; <i>p</i> < 0.0001). Complete responses to treatment were associated with no impairments on the dermatology-QoL, no interferences with sleep and activity, and significantly improved capacities to work compared to patients who continued to have signs and symptoms, even for those with minimal disease activity.
Physical, chemical, and some biological properties of strained ring hydrocarbons (1980)

Abstract
Risk of fetal loss after chorionic villus sampling in twin pregnancy derived from propensity score matching analysis (2021)

In twin pregnancy, after accounting for the risk factors that lead to both CVS and spontaneous fetal loss and confining the analysis to pregnancies at lower prior risk, CVS seems to increase the risk of fetal loss by about 3.5% above the patient's background risk. © 2021 International Society of Ultrasound in Obstetrics and Gynecology.
Understanding sensitization behavior of lead selenide photoconductive detectors by charge separation model (2014)

We introduce a charge separation model in this work to explain the mechanism of enhanced photoconductivity of polycrystalline lead salt photoconductors. Our results show that this model could clarify the heuristic fabrication processes of such lead salt detectors that were not well understood and often considered mysterious for nearly a century. The improved lifetime and performance of the device, e.g., responsivity, are attributed to the spatial separation of holes and electrons, hence less possibility of carrier recombination. This model shows that in addition to crystal quality the size of crystallites, the depth of outer conversion layer, and doping concentration could all affect detector performance. The simulation results agree well with experimental results and thus offer a very useful tool for further improvement of lead salt detectors. The model was developed with lead salt family of photoconductors in mind, but may well be applicable to a wider class of semiconducting films.
Dual-Level Silicon Grating Coupler with a Record -0.8 dB Coupling Efficiency (2023)

We report the design, fabrication and experimental characterization of a dual-level grating coupler for a 220 nm thick silicon photonics platform with a record coupling efficiency of -0.8 dB without the use of any back-reflector.
Imaging the neuroimmune response to alcohol exposure in adolescent baboons: a TSPO PET study using 18F‐DPA‐714 (2017)

The effects of acute alcohol exposure to the central nervous system are hypothesized to involve the innate immune system. The neuroimmune response to an initial and acute alcohol exposure was investigated using translocator protein 18 kDa (TSPO) PET imaging, a non-invasive marker of glial activation, in adolescent baboons. Three different alcohol-naive adolescent baboons (3-4 years old, 9 to 14 kg) underwent <sup>18</sup> F-DPA-714 PET experiments before, during and 7-12 months after this initial alcohol exposure (0.7-1.0 g/l). The brain distribution of <sup>18</sup> F-DPA-714 (V<sub>T</sub> ; in ml/cm<sup>3</sup> ) was estimated in several brain regions using the Logan plot analysis and the metabolite-corrected arterial input function. Compared with alcohol-naive animals (V<sub>Tbrain</sub> = 3.7 ± 0.7 ml/cm<sup>3</sup> ), the regional V<sub>T</sub> s of <sup>18</sup> F-DPA-714 were significantly increased during alcohol exposure (V<sub>Tbrain</sub> = 7.2 ± 0.4 ml/cm<sup>3</sup> ; p < 0.001). Regional V<sub>T</sub> s estimated several months after alcohol exposure (V<sub>Tbrain</sub> = 5.7 ± 1.4 ml/cm<sup>3</sup> ) were lower (p < 0.001) than those measured during alcohol exposure, but remained significantly higher (p < 0.001) than in alcohol-naive animals. The acute and long-term effects of ethanol exposure were observed globally across all brain regions. Acute alcohol exposure increased the binding of <sup>18</sup> F-DPA-714 to the brain in a non-human primate model of alcohol exposure that reflects the 'binge drinking' situation in adolescent individuals. The effect persisted for several months, suggesting a 'priming' of glial cell function after initial alcohol exposure.
Stationary premixed flames in spherical and cylindrical geometries (1994)

Stationary source-free spherical flames ('flame balls') in premixed combustible gases were studied by employing low-gravity (micro-g) environments in a drop tower and an aircraft flying parabolic trajectories to diminish the impact of buoyancy-induced convective flow. Flame balls were found in all mixture families tested when: (1) the Lewis number Le of the deficient reactant was sufficiently low; and (2) the compositions were sufficiently close to the flammability limits. Probably as a consequence of the reduction in buoyant convection, the flammability limits at micro-g were significantly more dilute than those at Earth gravity; for example, 3.35% H2 vs 4.0% H2 in lean H2-air mixtures. By comparison with analytical and computational models, it is inferred that the phenomenon is probably related to diffusive-thermal effects in low-Le mixtures in conjunction with flame-front curvature and radiative heat losses from the combustion products. The chemical reaction mechanism appears to play no qualitative role. In the aircraft experiments, the gravity levels (approximately equal 10(exp -2)g(sub 0)) were found to cause noticeable motion of flame balls due to buoyancy, which in turn influenced the behavior of flame balls. At these g levels, a new type of transient, nearly cylindrical flame structure, termed 'flame strings,' was observed.
Modified Generalized Alpha Method for Integrating Governing Equations of Very Flexible Aircraft (2006)

This paper focuses on the time integration of the nonlinear EOM associated with a very ∞exible aircraft in ∞ight. Various integration methods exist for linear structural dynamics problems. However, a review of the literature indicates little material associated with the integration of nonlinear structural EOM of relatively large order. Moreover, for the problem of simulation of very ∞exible aircraft, a combination of ∞ight dynamics and aeroelastic degrees of freedom must be solved. A modifled flrst and second order Generalizedfi Method along with an implicit sub-iteration scheme were developed. It has shown good agreement with predictor/corrector integration schemes for a reduced set of linear EOM. The method is also seen to be numerically stable when compared to non-dissipative time marching integration schemes and requires less computational time compared to predictor/corrector methods for the full set of nonlinear EOM.
Algal turf scrubber (ATS) floways on the Great Wicomico River, Chesapeake Bay: productivity, algal community structure, substrate and chemistry1 (2013)

Two Algal Turf Scrubber (ATS) units were deployed on the Great Wicomico River (GWR) for 22 months to examine the role of substrate in increasing algal productivity and nutrient removal. The yearly mean productivity of flat ATS screens was 15.4 g · m(-2) · d(-1) . This was elevated to 39.6 g · m(-2) · d(-1) with a three-dimensional (3-D) screen, and to 47.7 g · m(-2) · d(-1) by avoiding high summer harvest temperatures. These methods enhanced nutrient removal (N, P) in algal biomass by 3.5 times. Eighty-six algal taxa (Ochrophyta [diatoms], Chlorophyta [green algae], and Cyan-obacteria [blue-green algae]) self-seeded from the GWR and demonstrated yearly cycling. Silica (SiO2 ) content of the algal biomass ranged from 30% to 50% of total biomass; phosphorus, nitrogen, and carbon content of the total algal biomass ranged from 0.15% to 0.21%, 2.13% to 2.89%, and 20.0% to 25.7%, respectively. Carbohydrate content (at 10%-25% of AFDM) was dominated by glucose. Lipids (fatty acid methyl ester; FAMEs) ranged widely from 0.5% to 9% AFDM, with Omega-3 fatty acids a consistent component. Mathematical modeling of algal produ-ctivity as a function of temperature, light, and substrate showed a proportionality of 4:3:3, resp-ectively. Under landscape ATS operation, substrate manipulation provides a considerable opportunity to increase ATS productivity, water quality amelioration, and biomass coproduction for fertilizers, fermentation energy, and omega-3 products. Based on the 3-D prod-uctivity and algal chemical composition demonstrated, ATS systems used for nonpoint source water treat-ment can produce ethanol (butanol) at 5.8× per unit area of corn, and biodiesel at 12.0× per unit area of soy beans (agricultural production US).
Involvement of JNK in TNFα driven remodelling (2015)

We showed that in mice constitutively overexpressing TNFα in type II pneumocytes (SPC-TNFα) airway and alveolar extracellular matrix remodeling are similar and comparable to COPD patients (1,2). Epithelial cells can contribute to matrix remodeling by undergoing a phenotypic shift, whereby epithelial properties are attenuated, and characteristics and functions of mesenchymal cells gained. TNFα is known to induce JNK signaling, shown to be involved in TGFb-induced plasticity. Therefore we hypothesize that TNFα induces JNK-dependent epithelial plasticity which contributes to matrix remodeling. The ability of TNFα to induce a phenotypic shift was assessed in A549 and BEAS2B cells and involvement of JNK investigated using a pharmacological inhibitor. In addition, phenotypic markers and JNK activation were studied in SPC-TNFα mice. Our results shown that in SPC-TNFα mice and in vitro in TNFα stimulated alveolar and bronchial epithelial cells, expression of phenotypic markers of mesenchymal cells, including expression of PAI1, vimentin, collagen and MMP2 and 9 were elevated. Expression of the epithelial markers E-cadherin and keratin 7 and 18 were attenuated. JNK signalling was shown to be involved in the induction of this phenotypic change by TNFα in alveolar and bronchial epithelial cells. The percentage of pJNK positive cells was furthermore increased in airways and alveoli of SPC-TNFα mice in which extracellular matrix alterations were previously characterized. Together, these data show a role for TNFα in the induction of a phenotypic shift in vitro and provide evidence for involvement of the TNFα-JNK axis in extracellular matrix remodelling. Eurlings IM <i>et al.</i> AJP Lung 2014; 307(7):L557-65 Eurlings <i>et al.</i> BMC Pulm Med 2014; 14:90.