gebhart/patrepeval huggingface dataset:
Topoisomerase IIβ Binding Protein 1 c.*229C>T (rs115160714) Gene Polymorphism and Endometrial Cancer Risk (2013)

TopBP1 (topoisomerase IIβ binding protein 1) protein is involved in DNA replication, DNA damage checkpoint response and transcriptional regulation. In this study we investigated whether alterations in the TopBP1 gene can influence the risk of endometrial cancer. We examined the association between five single nucleotide polymorphisms (rs185903567, rs116645643, rs115160714, rs116195487, and rs112843513) located in the 3'UTR region of the TopBP1 gene and endometrial cancer risk as well as allele-specific gene expression. One hundred twenty-one endometrial cancer patients were genotyped for these SNPs. Allele-specific TopBP1 mRNA and protein expressions were determined by real time PCR and western blotting methods, respectively. Only one SNP (rs115160714) showed an association with endometrial cancer. Compared to homozygous common allele carriers, heterozygous for the T variant had significantly increased risk of endometrial cancer [adjusted odds ratio (OR) = 5.59, 95 % confidence interval (CI): 1.96-15.91, p = 0.0003]. Mean TopBP1 mRNA and protein expression were higher in the individuals with the CT genotype. There was a significant association between the rs115160714 and tumor grade and FIGO classification. Most carriers of minor allele had a high grade tumors (G3) classified as FIGO III/IV. The results of our study raise a possibility that a genetic variation of TopBP1 may be implicated in the etiology of endometrial cancer.
Novel automated pulse immunoassay for human alpha-fetoprotein (2009)

The performance of AFP reagents in the PIA device shows that the system has excellent speed and equal sensitivity and specificity compared with the most highly sensitive conventional method. Our PIA system thus appears ready for use in the clinical diagnosis setting.
A Comparison Study of the of the CO2-Oil Physical Properties Literature Correlations Accuracy Using Visual Basic Modelling Technique (2009)

A key parameter in a CO2 flooding process is the gas solubility as it contributes to oil viscosity reduction and oil swelling, which together, in turn, enhance the oil mobility and oil relative permeability. Often injected gas-oil mixture physical properties parameters are established through time-consuming experimental means or using correlations available in the literature. However, one must recognise that such correlations for predicting the injected CO2oil physical properties are valid usually for certain data ranges or site-specific conditions. In this paper , a comparison has been presented between the literature correlations for CO2-oil physical properties using excel spreadsheet and also using Visual Basic soft ware. Emera and Sarma (2006) correlations have yielded more accurate predictions with lower errors than the other tested models for all the tested physical properties (CO2 solubility, oil swelling due to CO2, CO2-oil density, and CO2-oil viscosity). Furthermore, unlike the literature models, which were applicable to only limited data ranges and conditions, Emera and Sarma models could be applied over a wider range and conditions. The developed Visual Basic software can be used to test which correlation presents the best accuracy between a list of different literature correlations for CO2-oil physical properties and then once the best correlation has been selected, the user can go to this correlation and use it in predicting the property (CO2 solubility, oil swelling due to CO2, CO2-oil density, and CO2oil viscosity) when no experimental data are not available.
Thickness Measurement of Circular Metallic Film Using Single-Frequency Eddy Current Sensor (2021)

In many advanced industrial applications, the thickness is a critical index, especially for metallic coatings. However, the variance of lift-off spacing between sensors and test pieces affects the measured voltage or impedance, which leads to unreliable results from the sensor. Massive research works have been proposed to address the lift-off issue, but few of them applies to the thickness measurement of planar metallic films with finite-size circular (disk) geometry. Previously, a peak-frequency feature from the swept-frequency inductance was used to compensate the measurement error caused by lift-offs, which was based on the slow-changing rate of impedance phase term in the Dodd-Deeds formulas. However, the phase of measured impedance is nearly invariant merely on a limited range of sample thicknesses and working frequencies. Besides, the frequency sweeping is time-consuming, where a recalibration is needed for different sensor setups applied to the online real-time measurement. In this paper, a single-frequency algorithm has been proposed, which is embedded in the measurement instrument for the online real-time retrieval of thickness. Owing to the single-frequency measurement strategy, the proposed method does not need to recalibrate for different sensor setups. The thickness retrieval is based on a triple-coil sensor (with one transmitter and two receivers). The thickness of metallic disk foils is retrieved from the measured electrical resistance of two transmitter-receiver sensing pairs. Experiments on materials of different electrical conductivities (from direct current), thicknesses and planar sizes (radii) have been carried out to verify the proposed method. The error for the thickness retrieval of conductive disk foils is controlled within 5 % for lift-offs up to 5 mm.
La fundación del Manicomio de Miraflores en Sevilla (2008)

En la segunda mitad del siglo XIX, el Reglamento general para la ejecucion de la Ley de beneficencia de 20 de junio de 1849, aprobado por Real decreto de 14 de mayo de 1852, y el proyecto del manicomio modelo activaron el interes por la asistencia psiquiatrica. En el Hospital de las Cinco Llagas existia un departamento de dementes, pero despues de hacer publico los defectos, fundamentalmente estructurales, agravados por el paso del tiempo, surgio la necesidad de construir otro. Tras fallidos intentos de varios anteproyectos hallamos una respuesta individual, la de Sor Ursula de Villabaso. La proteccion de la Diputacion Provincial junto al entusiasmo de la Comunidad de San Vicente de Paul, del decano del Cuerpo Facultativo, del arquitecto y de todo el personal de la casa aseguraba la resolucion de este instituto. El objetivo del presente trabajo es precisamente tratar de conocer dicha fundacion. En las fuentes utilizadas se deben de destacar dos pilares fundamentales en nuestro estudio: el Archivo de la Diputacion Provincial, el Archivo Municipal y la Hemeroteca de la ciudad de Sevilla.
Processing video-SAR data with the fast backprojection method (2016)

Video synthetic aperture radar (video-SAR) is a land-imaging mode where a sequence of images is continuously formed when the radar platform either flies by or circles the scene. In this paper, the fast backprojection (FBP) algorithm is introduced for video-SAR image formation. It avoids unnecessary duplication of processing for the overlapping parts between consecutive video frames and achieves O(N2 log N) complexity through a recursive procedure. To reduce the processing complexity in video-SAR system, the scene is partitioned into the general region (GR) and the region of interest (ROI). In different regions, different aperture lengths are used. The proposed method allows a direct trade between processing speed and focused quality for the GR, meanwhile reserving particular details in the ROI. The effectiveness is validated both for a simulated scene and for X-band SAR measurements from the Gotcha data set.
Design and implementation of a Chinese full-text retrieval system based on a probabilistic model (2002)

Full-text retrieval has the advantages of searching documents over a wide range of words and accessing original text directly. However, because of the inadequate processing speed and insufficient memory capacity, there has been little work done on full text retrieval systems in the past. With the emergence of very large capacity compact disk ROM (CD ROM), research in full-text retrieval systems is becoming increasingly important. Practical systems based on Boolean retrieval models have appeared. However, in spite of its ability to process structured queries, the Boolean model has been criticised for its inability to provide ranked output as all retrieved documents are considered equally important. Probabilistic models have been proposed by some scholars to solve this problem and have successfully been implemented on a small scale trial basis in indexing retrieval systems. This paper focuses on applying the probabilistic model into the full-text retrieval system.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The Determination of Iodine in Milk and Milk Chocolate by Anion HPLC (1983)

Abstract An HPLC method is described for the extraction and analysis of iodine as iodide in milk, cocoa beans and milk chocolate. Prior to analysis samples are finely ground if necessary and combusted in a modified Shoeninger flask. The liberated halide is absorbed in a basic reducing medium which is concentrated and brought to volume with distilled water prior. HPLC analysis used an 8 mm 5μ C18 cartridge in a RCM-100 with detection of the iodide ion at 226 nm. The mobile phase consisted of an ion-pairing agent, buffer and acetonitrile. The method is accurate and precise showing reasonable agreement with a National Bureau of Standards spray dried milk sample.
Control of androgen receptor signaling in prostate cancer by the cochaperone small glutamine rich tetratricopeptide repeat containing protein alpha. (2007)

Although the androgen receptor (AR) is accepted as the major determinant of prostate cancer cell survival throughout disease progression, it is currently unclear how the receptor sustains genomic signaling under conditions of systemic androgen ablation. Here, we show that the evolutionarily conserved Hsp70/Hsp90 cochaperone, small glutamine-rich tetratricopeptide repeat containing protein alpha (alphaSGT), interacts with the hinge region of the human AR in yeast and mammalian cells. Overexpression and RNA interference revealed that alphaSGT acts to (a) promote cytoplasmic compartmentalization of the AR, thereby silencing the receptors basal/ligand-independent transcriptional activity, (b) regulate the sensitivity of receptor signaling by androgens, and (c) limit the capacity of noncanonical ligands to induce AR agonist activity. Immunofluorescence, coactivator, and chromatin immunoprecipitation analyses strongly suggest that these effects of alphaSGT on AR function are mediated by interaction in the cytoplasm and are distinct from the receptors response to classic coregulators. Quantitative immunohistochemical analysis of alphaSGT and AR levels in a cohort of 32 primary and 64 metastatic human prostate cancers revealed dysregulation in the level of both proteins during disease progression. The significantly higher AR/alphaSGT ratio in metastatic samples is consistent with the sensitization of prostate tumor cells to androgen signaling with disease progression, particularly in a low-hormone environment. These findings implicate alphaSGT as a molecular rheostat of in vivo signaling competence by the AR, and provide new insight into the determinants of androgen sensitivity during prostate cancer progression.
Bit-stream-based space vector modulators (2012)

Bit-stream-based control, which uses one bit wide signals to control power electronics applications, is a new approach for controller design in power electronic systems. This study presents a novel family of three-phase space vector modulators, which are based on the bit-stream technique and suitable for three-phase inverter systems. Each of the proposed modulators simultaneously converts a two-phase reference to the three-phase domain and reduces switching frequencies to reasonable levels. The modulators do not require carrier oscillators, trigonometric functions or, in some cases, sector detectors. A complete three-phase modulator can be implemented in as few as 102 logic elements. The performance of the proposed modulators is compared through simulation and experimental testing of a 6 kW, three-phase DC-to-AC inverter. Subject to limits on the modulation index, the proposed modulators deliver spread-spectrum output currents with total harmonic distortion comparable to a standard carrier-based space vector pulse width modulator.
Advanced Micro‐Lattice Materials (2015)

Topological management of materials at a Micro‐scale is one of the fundamental building principles of nature. This combination of material and structural properties results in marked changes in the properties of solids. Nowadays physicists, chemists, materials scientists and engineers explore those effects by synthesizing, characterizing, and modeling Micro‐lattice materials from all material classes. Applications have been identified in the fields of ultra‐lightweight structures, thermal equipment, electrochemical devices, high absorption capacity and bio‐repair materials. This article aims to review recent progress in the development of such advanced Micro‐lattice materials.
A wideband NMOS balanced modulator/amplifier which uses 1μm transistors for linearity (1987)

A balanced modulator/amplifier which uses saturated short channel (1μm) NMOS transistors to achieve low distortion is described. Operated with a 5V power supply, the circuit has a gain of 10, 3dB bandwidth near 100MHz, and nonlinearity less than 0.5% for a differential output amplitude of 4V P-P.
Role of interleukin-10 in regulation of T-cell-dependent and T-cell-independent mechanisms of resistance to Toxoplasma gondii (1997)

Interleukin-10 (IL-10) is a cytokine which can inhibit T-cell and natural killer (NK) cell functions associated with cell-mediated immunity to intracellular infections. The production of IL-10 by mice infected with Toxoplasma gondii has been implicated in the suppression of lymphocyte proliferation observed during acute toxoplasmosis, as well as susceptibility to infection with this parasite. We have used C57BL/6 mice which lack a functional IL-10 gene (IL-10(-/-) mice) to investigate the role of IL-10 in acute toxoplasmosis. Intraperitoneal infection of IL-10(-/-) mice with T. gondii resulted in 100% mortality by day 13, whereas wild-type C57BL/6 (WT) mice survived acute infection. IL-10(-/-) mice infected with T. gondii had significantly higher serum levels of IL-12 and gamma interferon (IFN-gamma) than WT mice. Early mortality of infected IL-10(-/-) mice was prevented by treatment with IL-10 and significantly delayed by neutralizing antibodies to IL-12 and IFN-gamma. Further studies revealed that SCID/IL-10(-/-) mice infected with T. gondii had delayed time to death compared to IL-10(-/-) mice, indicating that lymphocytes contributed to death of IL-10(-/-) mice. In addition, infected SCID/IL-10(-/-) mice survived longer than infected SCID mice. These latter data indicate that in mice lacking lymphocytes, endogenous IL-10 is associated with increased susceptibility to T. gondii. However, the lack of IL-10 does not alter the infection-induced suppression of T cell and NK cell functions. Our experiments reveal that IL-10 is associated with protection or increased susceptibility to infection with T. gondii, depending on whether mice possess lymphocytes, and demonstrate the important roles of IL-12 and IFN-gamma in the early infection-induced mortality observed in the IL-10(-/-) mice.
Left ventricular dynamics during recovery from exercise (1975)

Left ventricular dynamics during recovery were measured in dogs, 3 min after brief periods of mild, moderate, and severe treadmill exercise. As compared with resting values, stroke volume was unchanged, and the maximum first derivative of the left ventricular pressure was either unchanged or slightly elevated. Increases in heart rate of 20, 26, and 46 beats/min for mild, moderate, and severe exercise appear to be the major factor in augmenting cardiac output during recovery. With moderate and severe exercise, left ventricular end-diastolic diameter increased and continued to be elevated during recovery, whereas end-systolic diameter decreased during exercise but was elevated above resting values during recovery. Therefore, with strenuous exercise, a sympathetic-mediated increase in contractility recedes promptly during the postexercise period but the Frank-Starling mechanism continues to be a factor.
Calcium-G Protein Interactions in the Regulation of Macrophage Secretion (2001)

The interplay between activated G proteins and intracellular calcium ([Ca(2+)](i)) in the regulation of secretion was studied in the macrophage, coupling membrane capacitance with calcium-sensitive microfluorimetry. Intracellular elevation of either the nonhydrolyzable analogue of GTP, guanosine-5'-O-(3-thiotriphosphate) (GTP gamma S), or [Ca(2+)](i) enhanced the amplitude and shortened the time course of stimulus-induced secretion in a dose-dependent manner. Both the ionophore- and the stimulus-induced secretory response were abolished in the presence of guanosine-5'-O-(2-thiodiphosphate) (GDP beta S). The K(d) of Ca(2+)-driven secretion was independent of GTP gamma S concentration, whereas the K(d) of the GTP gamma S-driven response decreased from 63 to 31 microM in the presence of saturating concentrations of [Ca(2+)](i). The time course of stimulus-induced secretion was dependent upon the concentration of [Ca(2+)](i). The time course of GTP gamma S-driven secretion was concentration-independent at high levels of [Ca(2+)](i), suggesting that a calcium-dependent translocation/binding step was rate-limiting. Our data strongly support a model in which [Ca(2+)](i) and activated G proteins act independently of one another in the sequential regulation of macrophage secretion. [Ca(2+)](i) appears to play a role in the recruitment and priming of vesicles from reserve intracellular pools at a step that is upstream of G protein activation. While activated, G proteins appear to play a key role in fusion of docked vesicles. Thus, secretion can result either from activating more G proteins or from elevating [Ca(2+)](i) at basal levels of G protein activation.
A Sweep Velocity-Controlled VCSEL Pulse Laser to Interrogate Sub-THz-Range Fiber Sensors (2017)

This letter reports an all-digital sweep velocitycontrolled pulse laser with enhanced sweep bandwidth. A vertical cavity surface emitting laser was employed as the optical source. An all-digital phase locked loop was designed and implemented using a field programmable logic array chip to lock the laser sweep velocity within each chirped pulse. A laser temperature controller was used to tune the operation temperature to enhance the laser mode-hop-free bandwidth, resulting in a total frequency excursion of 212.12 GHz and a constant sweep velocity of 30.28 GHz/ms. The system was further adopted to interrogate a sub-terahertz-range fiber sensor array. A series of static strain tests were conducted to demonstrate the system sensing capability. Highly linear results with a sensitivity of -0.1426 GHz/με were observed.
Origin and development of grain and twin boundaries in PV Silicon. (2012)

Keynote
Microencapsulation of a Colombian Spodoptera frugiperdaNucleopolyhedrovirus with Eudragit® S100 by spray drying (2015)

A Colombian Spodoptera frugiperda nucleopolyhedrovirus NPV003 with high potential for the development of an efficient biopesticide was microencapsulated by spray drying with a pH dependent polymer (Eudragit® S100). Conditions for microparticles production were standardized and microencapsulation process was validated. Physical properties, insecticide activity and photo-stability of microencapsulated virus were determined. The microparticles were spherical and irregular shaped, with sizes between 17.64 and 19.47 µm. Moisture content was 10.38 ± 0.87%; encapsulation efficiency 84.61± 13.09% and process yield was 91.20 ± 6.40%. Microencapsulation process did not affect viral insecticidal activity and provided efficient protection against UVB radiation. Results demonstrated technological feasibility of spray drying process to be used in formulating a biopesticide based on NPV003.
<title>Searching near-replicas of images via clustering</title> (1999)

Internet piracy has been one of the major concerns for Web publishing. In this study we present a system, RIME, that we have prototyped for detecting unauthorized image copying on the WWW. To speed up the copy detection, RIME uses a new clustering/hashing approach that first clusters similar images on adjacent disk cylinders and then builds indexes to access the clusters made in this way. Searching for the replicas of an image often takes just one IO to loop up the location of the cluster containing similar objects and one sequential file IO to read in this cluster. Our experimental results show that RIME can detect images copies both more efficiently and effectively than the traditional content- based image retrieval systems that use tree-like structures to index images. In addition, RIME copes well with image format conversion, resampling, requantization and geometric transformation.
The family of local C2 splines with two free generating functions (1993)

The family of local generalised C2 splines with two free generating functions is proposed. Cases of one-dimensional and bidimensional interpolation are discussed with numerical examples.
Optimal growth of Lactobacillus casei in a Cheddar cheese ripening model system requires exogenous fatty acids (2012)

Flavor development in ripening Cheddar cheese depends on complex microbial and biochemical processes that are difficult to study in natural cheese. Thus, our group has developed Cheddar cheese extract (CCE) as a model system to study these processes. In previous work, we found that CCE supported growth of Lactobacillus casei, one of the most prominent nonstarter lactic acid bacteria (NSLAB) species found in ripening Cheddar cheese, to a final cell density of 10(8) cfu/mL at 37°C. However, when similar growth experiments were performed at 8°C in CCE derived from 4-mo-old cheese (4mCCE), the final cell densities obtained were only about 10(6) cfu/mL, which is at the lower end of the range of the NSLAB population expected in ripening Cheddar cheese. Here, we report that addition of Tween 80 to CCE resulted in a significant increase in the final cell density of L. casei during growth at 8°C and produced concomitant changes in cytoplasmic membrane fatty acid (CMFA) composition. Although the effect was not as dramatic, addition of milk fat or a monoacylglycerol (MAG) mixture based on the MAG profile of milk fat to 4mCCE also led to an increased final cell density of L. casei in CCE at 8°C and changes in CMFA composition. These observations suggest that optimal growth of L. casei in CCE at low temperature requires supplementation with a source of fatty acids (FA). We hypothesize that L. casei incorporates environmental FA into its CMFA, thereby reducing its energy requirement for growth. The exogenous FA may then be modified or supplemented with FA from de novo synthesis to arrive at a CMFA composition that yields the functionality (i.e., viscosity) required for growth in specific conditions. Additional studies utilizing the CCE model to investigate microbial contributions to cheese ripening should be conducted in CCE supplemented with 1% milk fat.
Electroporation for Electrochemotherapy and Gene Therapy (2004)

When a cell is exposed to an electric field, a transmembrane voltage is induced on the membrane. If this voltage exceeds a certain value, this leads to a significant increase of the electric conductivity and the permeability of the membrane. Typically, each increases by several orders of magnitude. Formation of a state of increased permeability of the membrane caused by an exposure to the electric field is called electroporation (also electropermeabilization).