gebhart/patrepeval huggingface dataset:
Antiproliferative Cardenolides from the Aerial Parts of Pergularia tomentosa (2019)

The LC-MS analysis of the MeOH extract of the aerial parts of Pergularia tomentosa led to the isolation of 23 compounds, of which the structures were elucidated unambiguously by NMR spectroscopic data analysis. Three new doubly linked cardenolides (4, 13, 14) along with several known cardenolides (1-3, 5, 7, 8, 15-23) and flavonol glycosides (6, 9-12) were identified. LC-HRESIMS analysis, in the negative-ionization mode, showed the absence of flavonoids in a methanol extract of the roots of P. tomentosa. On the basis of the antiproliferative activity reported for cardenolides, the isolated compounds were tested for their ability to decrease the cell viability of five different human cancer cell lines, PC3, HeLa, Calu-1, MCF-7, and U251MG, exhibiting IC<sub>50</sub> values ranging from 0.2 to 8.0 μM. Moreover, an S-phase entry assay was performed to investigate if the compounds could affect the cell cycle progression of PC3 prostate carcinoma cells. The results obtained demonstrated that the compounds 4, 7, and 14 at 1 μM considerably reduced the number of cells in the S-phase.
A New CRONE Suspension: More Compact and More Efficient: Part 1—Problematics and Specifications (2009)

This paper presents, in 2 parts, a new CRONE suspension approach. The first part defines the problematics in suspension and gives the different conditions to overcome it. Then in the second paper a new CRONE suspension system is synthesized based on the conclusion of this paper. So, here, is presented how the variations of mass act on the classical suspension and how tools can be set up to simulate the influence of this variation without to choose the technological structure. Then a criterion on the level of wheel holding is established.
A STUDY OF DENTAL TREATMENT AND THE RESPONSE OF THE PARENTS OF THE DENTALLY HANDICAPPED PATIENTS TREATED UNDER OUT-PATIENT GENERAL ANESTHESIA (2003)

Under this thesis, 235 patients with dental problems treated under general anesthesia at the Pediatric Dentistry Clinic of Yonsei Dental College were surveyed and their age distribution, reasons for taking general anesthesia, duration of anesthesia, duration of dental procedure, dental treatment peformed and complications were analyzed. A questionnaire survey was also conducted to analyze degrees of anxiety and satisfaction among their parents according to the parents' age, educational background and experience of general anesthesia, as well as the patients' age and past dental history. Following are the results. 1. When the patients were treated under general anesthesia, the degree of anxiety of their mothers was higher than that of their fathers. It appeared that the higher the parents' educational background was, the less their anxiety. 2. The higher the parents' educational level was, the higher the degree of satisfaction after treatment under general anesthesia. 95 cases (87.2%) responded that they would accept such treatment again, if needed. From the result, dental treatment under general anesthesia causes anxiety for parent but the parent's satisfaction level was high. And that was the way gives good quality of dental service to unmanagable patients.
Model Linear Block Co-, Ter-, and Quaterpolymers of 1,3-Cyclohexadiene with Styrene, Isoprene, and Butadiene (2002)

The following linear block co-, ter-, and quaterpolymers of 1,3-cyclohexadiene (CHD) with styrene (S), isoprene (I), and butadiene (B) were synthesized by sequential anionic polymerization: PS-b-PCHD, PI-b-PCHD, PB-b-PCHD, PS-b-PB-b-PCHD, PB-b-PS-b-PCHD, PB-b-PI-b-PCHD, and PS-b-PB-b-PI-b-PCHD. sec-Butyllithium with either N,N,N‘,N‘-tetramethylethylenediamine (TMEDA) or 1,4-diazobicyclo[2.2.2]octane (DABCO) was used as the initiating system. In all cases CHD was the last monomer added. The polar additive (TMEDA or DABCO) was always introduced to the polymerization solution prior to the addition of CHD and isoprene. The microstructures of the polydienes obtained in the different environments were determined by NMR spectroscopy. Thorough characterization by size exclusion chromatography coupled with multiangle laser light scattering, laser differential refractometry, osmometry, and NMR spectroscopy revealed that the synthesized polymeric materials exhibit high molecular and compositional homogeneity.
Use of microRNAs expression profiles to classify the responsiveness of human osteosarcoma to doxorubicin, cisplatin, and ifosfamide (2008)

10515 Background: Despite the increased survival rates of osteosarcoma patients attributed to adjuvant chemotherapy, at least one third of the patients still succumb to their disease. Furthermore, ultra-aggressive combination chemotherapy is associated with considerable acute and long term toxicity. Further improvements in the management of osteosarcoma seemingly depend on diagnostic and prognostic tools that may allow for a more risk adapted and individualized treatment. Non-coding microRNAs hold great promise as new prognostic biomarkers. In this study, we systematically investigated the miRNA expression in response to doxorubicin, cisplatin or ifosfamide using osteosarcoma tumor xenografts that are either sensitive or resistant to these compounds. Methods: High throughput Luminex FlexmiR MiRNA Human Panel was utilized to quantify miRNAs expression profiles from a panel of human osteosarcoma xenografts. The clustering analysis was performed using GeneSpring software to group xenografts based on their sensitivity to each of the three drug treatments with 2-fold cut off. Results: There are 22 miRNAs associated with doxorubicin sensitivity and 36 and 29 miRNAs to cisplatin and ifosfamide, respectively. Venn diagram analysis showed 3 overlapping miRNAs (miR-140, miR-217, and miR-431) among the three different drugs. There are 9 overlapping miRNAs between doxorubicin and cisplatin or cisplatin and ifosfamide. Doxorubicin and ifosfamide shared the other unique 5 miRNAs. It is interesting to note that miR-140 was highly overexpressed by an average of nearly 5.0 fold in the sensitive group vs. the resistance group to all three drugs. miR-140 is reported to be uniquely associated with bone development by targeting histone deacetylase 4, one of the critical targets for anti-cancer therapy due to its critical role in cell proliferation, differentiation and apoptosis. Conclusions: We have identified miRNAs as potential candidates to be classifiers of chemosensitivity to osteosarcoma treatment. Some of these miRNAs will be important to contribute our understanding of post-transcriptional control in drug resistance mechanism. No significant financial relationships to disclose.
Survey of treatment of primary breast cancer in Great Britain. (1985)

A postal survey of current management of breast cancer among surgeons in Great Britain was carried out. The results showed that there is no consensus among surgeons about the treatment of primary breast cancer. Many different types of primary surgery are practised, and patterns of referral for postoperative radiotherapy vary widely. Adjuvant systemic treatment is given often by some surgeons and not at all by others. Few patients are entered into controlled randomised trials.
Carbon Nanotubes as Assisted Matrix for Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (2003)

Analysis of low molecular weight compounds with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) has been developed by using carbon nanotubes obtained from coal by arc discharge as the matrix. The carbon nanotube matrix functions as substrate to trap analytes of peptides, organic compounds, and beta-cyclodextrin deposited on its surface. It has been found that carbon nanotubes can transfer energy to the analyte under laser irradiation, which makes analytes well desorbed/ionized, and the interference of intrinsic matrix ions can be eliminated. At the same time, the fragmentation of the analyte can be avoided. A good sensitivity and excellent reproducibility of the spectrum signals are achieved. It is believed that this work not only will open a new field for applications of carbon nanotubes, but also will offer a new technique for high-speed analysis of low molecular weight compounds in areas such as metabolism research and characterization of natural products.
Users are not the enemy (1999)

article Free Access Share on Users are not the enemy Authors: Anne Adams Univ. College of London, London, UK Univ. College of London, London, UKView Profile , Martina Angela Sasse Univ. College of London, London, UK Univ. College of London, London, UKView Profile Authors Info & Claims Communications of the ACMVolume 42Issue 12Dec. 1999pp 40–46https://doi.org/10.1145/322796.322806Published:01 December 1999Publication History 938citation17,061DownloadsMetricsTotal Citations938Total Downloads17,061Last 12 Months1,911Last 6 weeks335 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteView all FormatsPDF
Sucrose dilution of glycerol from mouse embryos frozen rapidly in liquid nitrogen vapour (1986)

The toxic effects of sucrose and the conditions of in-straw glycerol removal after freezing and thawing were studied using Day-3 mouse embryos. At 20 degrees C, exposure to less than or equal to 1.0 M-sucrose for periods up to 30 min had no adverse effects on freshly collected embryos. At 25 and 36 degrees C, however, greater than or equal to 1.0 M-sucrose significantly reduced the developmental potential (P less than 0.001). In the freezing experiments the embryos were placed in 0.5 ml straws containing 40 microliters freezing medium separated by an air bubble from 440 microliters sucrose solution. The straws were frozen rapidly in the vapour about 1 cm above the surface of liquid nitrogen. The post-thaw viability was substantially better after sucrose dilution at 20 degrees C than at 36 degrees C. Mixing the freezing medium with the sucrose diluent immediately after thawing further improved the rate of survival relative to mixing just before freezing (P less than 0.001). The best survival was obtained when the freezing medium contained 3.0 M-glycerol + 0.25 M-sucrose; it was mixed with the diluent after thawing and the glycerol was removed at 20 degrees C. Under such conditions the sucrose concentration in the diluent had no significant effect on the rate of development (0.5 M, 69%; 1.0 M, 73%; 1.5 M, 64%). The results show that during sucrose dilution the temperature should be strictly controlled and suggest that intracellular and extracellular concentrations of glycerol are important in the cryoprotection of embryos.
On achievable rates on time-varying frequency-selective channels (2002)

Note: inproceedings Reference LICOS-CONF-2002-002 Record created on 2006-12-11, modified on 2016-08-08
Design of a Coreless Multi-Phase Electric Motor Using Magnetic Resonant Coupling (2022)

With the emergence of electric vehicles and electric aircraft technologies, lightweight motors have become a requirement. Conventional motors are generally made up of coils, permanent magnets, heavy iron stators, and rotor cores. This article presents complete analytical modeling and design of a novel coreless multi-phase magnetic resonant motor (MMRM), conceptualized through the approach of magnetic resonance coupling. The removal of magnetic iron cores drastically reduces the weight of the resulting motor. The stator and rotor cores of the motor are made of reinforced plastic fibers and can be 3-D printed. Unrelated to the general operating principle of the existing conventional electric motors, resonant wireless power transfer (WPT) is the key feature of these motors. All the essential machine characteristics, such as self-inductance, mutual inductance, torque, and frequency domains, are fully developed. The mathematical modeling of the machine’s physical phenomena is linked to its operation by simulation. This article shows the design concept and discusses the simulation procedure used to verify the developed analytical model through a finite-element analysis (FEA) from the established modeling topology equivalent to the proposed configuration motor model. Although the design is straightforward, an accurate analytical modeling and analysis are significant challenges to consider.
A study of surgical management of distal femoral fractures in adults using locking compression plate (2017)

&lt;p class="abstract"&gt;&lt;strong&gt;Background:&lt;/strong&gt; The introduction of locking compression plates with option of locked screws has provided the means to increase the stability of fracture fixation.&lt;/p&gt;&lt;p class="abstract"&gt;&lt;strong&gt;Methods:&lt;/strong&gt; In this study, 30 distal femoral fractures were treated using the distal femoral locking compression plate. All fractures were fresh, closed and operated within 12 days. Follow up duration ranged from 6 to 18 months.&lt;strong&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p class="abstract"&gt;&lt;strong&gt;Results:&lt;/strong&gt; In this study, 20 patients were males and 10 were females. The 23 of the fractures (76.66%), were caused by road traffic accidents, 3 were due to accidental falls (10%), one was due to assault and 3 were due to fall from height.9 patients had associated injuries. All patients were treated with open reduction and internal fixation using Locking Compression Plate. 6 to 9 holed plates were used. Out of 30 patients 2 went for delayed union and 3 went for non-union. Average knee flexion was 109&lt;sup&gt;o&lt;/sup&gt; having knee range of motion more than 100 with 50% patients. Average knee extensor lag was 2.4 degrees with only 4 patients with lag more than 5. 2 patients developed 2 cm shortening. 4 patients had less than 5 degrees of malalignment. 2 patients had deep infection. Functional outcome was measured using NEER's scoring system and was done at the end of 5- 7 months (average of 6 months). Excellent results- 17 (56.66%) good results-8 (26.66%) fair results-2 (6.66%) poor results-3 (10%).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions:&lt;/strong&gt; LCP condylar plate represents an evolutionary approach to the surgical management and is an important armamentarium in distal femur fracture fixation, especially when fracture is severely comminuted and in situations of osteoporosis. &lt;/p&gt;
Crafting successful strategic technology partnerships (1999)

Despite the trend towards an increasing use of strategic technology alliances, mortality rates of cooperative agreements have always been extremely high. In this paper we argue that rapid economic and technological developments have overthrown traditional thinking about alliances and that firms could benefit from a new perspective on partnering. This new approach is referred to as High Touch Partnering. The new framework stresses the need for a balanced attention to strategic (re‐)positioning, establishing adequate alliance capabilities, building business communities with partners and improved partner selection.
Synthesis, Structure, and Catalytic Properties of Rare-Earth Ternary Sulfates (2005)

Three rare-earth ternary sulfates NaM(SO4)2·H2O (M = La, Nd, and Gd) have been hydrothermally synthesized, and the crystal structures of the three compounds have been solved by single-crystal X-ray diffraction. The lanthanum and neodymium sulfates show the space group P3121 while the gadolinium compound presents the enantiomer P3221. The three lanthanum, neodymium, and gadolinium sulfates have been tested as heterogeneous redox catalysts in the selective oxidation of sulfides, showing good activities and selectivities. They can be reused without loss of yield or selectivity.
Bilateral Mycobacterium abscessus keratitis after laser in situ keratomileusis (2002)

A 35-year-old man was diagnosed with Mycobacterium abscessus keratitis in the left eye 3 weeks after bilateral laser in situ keratomileusis (LASIK). Infection in the right eye developed 6 weeks after surgery. Despite aggressive treatment with topical amikacin and clarithromycin and oral clarithromycin, the infection progressed in both eyes. To improve antibiotic penetration, the LASIK flap was removed in both eyes. Culture positivity was prolonged; however, after 8 weeks of intensive topical antibiotics, the infection was eradicated. The final best corrected visual acuity was 20/30 in both eyes.
HALLERVORDEN-SPATZ SYNDROME WITH THE ONSET OF JAW OPENING DYSTONIA (2006)

Objectives: Hallervorden-Spatz syndrome (HSS) (Pantothenate kinase-associated neurodegeneration) is a rare degenerative disease with sporadic onset or autosomal recessive inheritance. Major clinical features include progressive dystonia beginning in the lower limbs, pigmentary retinopathy, spasticity, and cognitive decline. Early-onset childhood type is the most common type and the usual age of onset is approximately 5 years. Late-onset childhood type becomes symptomatic at the ages of 10–18 years and, other than its slower progression, its clinical onset is similar to the classical form. In this case report, a late onset HSS case with jaw opening dystonia is presented and in this aspect, etiologies of jaw opening dystonia, clinical variants of HSS and their features of onset have been evaluated.
The Emergence of Pandemic Influenza A: Bioterrorist Versus Mother Nature (2005)

This chapter contains sections titled: Can we Depend on Current Vaccines and Antivirals to Protect against Pandemic or Bioterrorist Influenza? X-Ray Crystallography of the Influenza Virus NA and the Development of a New Range of Antiviral Drugs: the NIs Practical Examples of Clinical Management of Influenza in an Outbreak Using the NIs Practical Examples of Clinical Management of Influenza Using Inhibitors of the Viral M2 Proton Pump Clinical Therapeutic Effects of Amantadine Modern Use of Low-Dose (100 mg) Amantadine New Mammalian Cell Techniques Versus Established Egg Methods to Rapidly Cultivate Influenza Virus for Vaccines in a Threat or Pandemic Situation New Influenza Vaccines that Could Induce Protection across the Different Subtypes WHO and National Planning for a Pandemic or Deliberate Outbreak Incidence of Illness in a Pandemic or Deliberately Caused Outbreak Mortality and Morbidity in a Pandemic The Impact of Pandemics on the Economy Lessons to be Learned from the Great Spanish Influenza Outbreak 1916–1919: Influenza Pandemics Do Not Always Start in Southeast Asia and May Have a Prolonged Gestation Period Could a Supervirulent Strain of Influenza a be Created in a Laboratory? Virulence Genes or Gene Segments of Pandemic Influenza a Virus from 1918 Have not Yet Been Identified Crystal Structure of the 1918 Influenza HA: the Key to Understanding Influenza Virus Virulence? Could a Mixture of Pneumococcus and Drug-Resistant Influenza a Virus be the Basis of a Hypervirulent Infection? Are There Lessons to be Learned from the Reemergence of Influenza a (H1N1) Viruses in 1976 and 1977? Conclusion References
RNAi Expression Vectors in Plant Cells (2004)

Suppression by double-stranded RNA (dsRNA) of expression of a target gene is known as RNA interference (RNAi). Tobacco BY-2 cell suspension has been used as a model cultured plant cell, because it is possible to produce populations of tobacco BY-2 cell suspensions that are uniform and divide synchronously for functional gene analysis. Here, we describe a method to induce RNAi by introducing a hairpin-type dsRNA expression vector into BY-2 cells via electroporation. This methodology should facilitate the analysis of individual gene function in plant cells.
Online multiple error detection in crossbar nano-architectures (2009)

Crossbar nano-architectures based on self-assembled nano-structures are promising alternatives for current CMOS technology, which is facing serious challenges for further down-scaling. One of the major challenges in this nanotechnology is elevated failure rate due to atomic device sizes and inherent lack of control in self-assembly fabrication. Therefore, high permanent and transient failure rates lead to multiple faults during lifetime operation of crossbar nano architectures. In this paper, we present a concurrent multiple error detection scheme for multistage crossbar nano-architectures based on dual-rail implementations of logic functions. We prove the detectability of all single faults as well as most classes of multiple faults in this scheme. Based on statistical multiple fault injection, we compare the proposed technique with other online error detection and masking techniques such as Triple Module Redundancy (TMR), duplication, and parity checking, in terms of fault coverage as well as area and delay overhead.
Supplementary document for Two-dimensional topological quantum walks in the momentum space of structured light - 4237518.pdf (2020)

.zip file containing the latex file and figures
The strand-biased mitochondrial DNA methylome and its regulation by DNMT3A (2019)

How individual genes are regulated from a mitochondrial polycistronic transcript to have variable expression remains an enigma. Here, through bisulfite sequencing and strand-specific mapping, we show mitochondrial genomes in humans and other animals are strongly biased to light (L)-strand non-CpG methylation with conserved peak loci preferentially located at gene-gene boundaries, which was also independently validated by MeDIP and FspEI digestion. Such mtDNA methylation patterns are conserved across different species and developmental stages but display dynamic local or global changes during development and aging. Knockout of <i>DNMT3A</i> alone perturbed mtDNA regional methylation patterns, but not global levels, and altered mitochondrial gene expression, copy number, and oxygen respiration. Overexpression of <i>DNMT3A</i> strongly increased mtDNA methylation and strand bias. Overall, methylation at gene bodies and boundaries was negatively associated with mitochondrial transcript abundance and also polycistronic transcript processing. Furthermore, HPLC-MS confirmed the methylation signals on mitochondria DNA. Together, these data provide high-resolution mtDNA methylation maps that revealed a strand-specific non-CpG methylation, its dynamic regulation, and its impact on the polycistronic mitochondrial transcript processing.
MOSE - A Simulation Environment for Mobile Communications Systems (1998)

Haematopoietically Expressed Homeobox (HHEX) gene is highly expressed in the thyroid gland and plays critical roles in the development and differentiation of the thyroid gland. While it has been indicated to be downregulated in thyroid cancer, its function and the underlying mechanism remain unclear. Herein, we observed low expression and aberrant cytoplasmic localization of HHEX in thyroid cancer cell lines. Knockdown of HHEX significantly enhanced cell proliferation, migration and invasion, while overexpression of HHEX showed the opposite effects in vitro and in vivo. These data provide evidence that HHEX is a tumor suppressor in thyroid cancer. Additionally, our results showed that HHEX overexpression upregulated the expression of sodium iodine symporter (NIS) mRNA and also enhanced NIS promoter activity, suggesting a favorable effect of HHEX in promoting thyroid cancer differentiation. Mechanistically, HHEX exerted a regulatory effect on the expression of transducin-like enhancer of split 3 (TLE3) protein, which inhibited the Wnt/β-catenin signaling pathway. Nuclear localized HHEX bound to and upregulated TLE3 expression by preventing TLE3 protein from being distributed to the cytoplasm and being ubiquitinated. In conclusion, our study suggested that restoring HHEX expression has the potential to be a new strategy in the treatment of advanced thyroid cancer.
Detection of Labyrinthine Fistulas in Human Temporal Bone by Virtual Endoscopy and Density Threshold Variation on Computed Tomographic Scan (2005)

Virtual endoscopy with variation of reconstruction threshold allows the detection of small labyrinthine fistulas with diameters of 0.3 mm or smaller.