gebhart/patrepeval huggingface dataset:
Indole and synthetic derivative activate chaperone expression to reduce polyQ aggregation in SCA17 neuronal cell and slice culture models (2014)

In spinocerebellar ataxia type 17 (SCA17), the expansion of a translated CAG repeat in the TATA box binding protein (TBP) gene results in a long polyglutamine (polyQ) tract in the TBP protein, leading to intracellular accumulation of aggregated TBP and cell death. The molecular chaperones act in preventing protein aggregation to ameliorate downstream harmful events. In this study, we used Tet-On SH-SY5Y cells with inducible SCA17 TBP/Q79-green fluorescent protein (GFP) expression to test indole and synthetic derivative NC001-8 for neuroprotection. We found that indole and NC001-8 up-regulated chaperone expression to reduce polyQ aggregation in neuronal differentiated TBP/Q79 cells. The effects on promoting neurite outgrowth and on reduction of aggregation on Purkinje cells were also confirmed with cerebellar primary and slice cultures of SCA17 transgenic mice. Our results demonstrate how indole and derivative NC001-8 reduce polyQ aggregation to support their therapeutic potentials in SCA17 treatment.
Electrodeposition of Ni-doped FeOOH oxygen evolution reaction catalyst for photoelectrochemical water splitting (2014)

The oxygen evolution reaction (OER) is one important bottleneck in the development of economical photoelectrochemical (PEC) water splitting materials. To help address this we report the electrodeposition of Ni-doped FeOOH (Ni:FeOOH) as an OER electrocatalyst. The deposition method is applicable to a wide range of photoanodes and catalytic films as thin as a few nanometers can be easily grown. The Ni:FeOOH films with 5–20% Ni content reach 10 mA cm−2 in 0.1 M NaOH at an overpotential ranging from 420–460 mV initially, and improve with anodization at 10 mA cm−2 to below 400 mV. Deposition on triple junction solar cells results in a full PEC system with higher performance and a more cathodic peak power potential compared to undoped FeOOH electrocatalysts.
Hybrid AR User Interfaces in Collaborative Gaming (2004)

This report documents the design and implementation of a number of hybrid user interfaces for the SmartSpace project. The SmartSpace project’s aim was to explore “how hybrid user interfaces can be developed that employ multi-modal input and display techniques to enable users to visualize and interact with geospatial content”(Billinghurst 2003). A proposed application of such a project was for a Command and Control application, for example a military operation where commanding officers need to visualize real-time data from soldiers in the field. The system designed for this project was based on a simulation of a military scenario, where teams of two or more players compete against each other by controlling a number of tanks, which they can order to capture objectives or attack the other team’s tanks. Because of the three dimensional characteristic of the environment in which this simulation takes place, an Augmented Reality interface was developed to allow users to view the data presented. Due to the non-tangible nature of Augmented Reality interfaces, a number of hybrid interfaces had to be developed to allow users to interact with the system.
ARIA, a protein that stimulates acetylcholine receptor synthesis, also induces tyrosine phosphorylation of a 185-kDa muscle transmembrane protein. (1993)

Motoneurons promote the accumulation of acetylcholine receptors (AChRs) at developing neuromuscular synapses. The AChR-inducing activity protein ARIA, which is purified from chicken brain and increases the synthesis of AChRs in chicken myotubes, may play a crucial role in this process. Here we show that ARIA induces the rapid tyrosine phosphorylation of a M(r) 185,000 protein (p185) in muscle cells. Phosphorylation of p185 correlates with AChR induction at each stage of ARIA purification. Moreover, medium conditioned by spinal cord motoneurons stimulates AChR synthesis and p185 phosphorylation. Studies with membrane-impermeant reagents and 125I-labeled ARIA indicate that p185 is a transmembrane ARIA-receptor tyrosine kinase. Our data suggests that muscle AChR synthesis can be regulated through tyrosine phosphorylation.
Verfahren zur Herstellung von Prüfgasen für die Eichung von Gasanalysatoren - eine Übersicht/ Methods of producing gaseous mixtures for the calibration of gas analyzers - a survey (1977)

Article Verfahren zur Herstellung von Prüfgasen für die Eichung von Gasanalysatoren - eine Übersicht/ Methods of producing gaseous mixtures for the calibration of gas analyzers - a survey was published on December 1, 1977 in the journal tm - Technisches Messen (volume 493, issue 2).
Neutron Temperature Distributions in a Cylinder of Hot Moderator (1963)

Relative reaction rates in selected nuclides have been measured through the central lattice cell of ZEEP with the fuel cluster replaced by a pressure tube containing different mixtures of light and heavy water. The surrounding heavy water moderator was at room temperature. Measurements were made with the pressure tube filled with air and four mixtures ranging from reactor grade heavy water to light water, at temperatures up to 280°C.The radial variations are given for the reaction rates, which were measured, and for the effective neutron temperature T and the epithermal index, deduced from the reaction rates.
β-Carboline Derivatives Tackling Malaria: Biological Evaluation and Docking Analysis (2020)

Increasing resistance to presently available antimalarial drugs urges the need to look for new promising compounds. The β-carboline moiety, present in several biologically active natural products and drugs, is an important scaffold for antimalarial drug discovery. The present study explores the antimalarial activity of a β-carboline derivative (1<i>R</i>,3<i>S</i>)-methyl 1-(benzo[<i>d</i>][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1<i>H</i>-pyrido[3,4-<i>b</i>]indole-3-carboxylate (<b>9a</b>) alone <i>in vitro</i> against <i>Plasmodium falciparum</i> and <i>in vivo</i> in combination therapy with the standard drug artesunate against <i>Plasmodium berghei</i>. Compound <b>9a</b> inhibited both 3D7 and RKL-9 strains of <i>P. falciparum</i> with half-maximal inhibitory concentration (IC<sub>50</sub>) < 1 μg/mL, respectively. The compound was nontoxic (50% cytotoxic concentration (CC<sub>50</sub>) > 640 μg/mL) to normal dermal fibroblasts. Selectivity index was >10 against both the strains. The compound exhibited considerable <i>in vivo</i> antimalarial activity (median effective dose (ED<sub>50</sub>) = 27.74 mg/kg) in monotherapy. The combination of <b>9a</b> (100 mg/kg) and artesunate (50 mg/kg) resulted in 99.69% chemosuppression on day 5 along with a mean survival time of 25.8 ± 4.91 days with complete parasite clearance. Biochemical studies indicated the safety of the HIT compound to hepatic and renal functions of mice. Molecular docking also highlighted the suitability of <b>9a</b> as a potential antimalarial candidate.
Modellbasierter Steuerungsentwurf für ein hydraulisches Bremssystem mit magnetischen Schaltventilen (Model-based Open-loop Control Design for a Hydraulic Brake System with Switching Solenoid Valves) (2007)

In dem vorliegenden Beitrag wird ein neuartiges Konzept für den modellbasierten Steuerungsentwurf für schaltende Gleichstrommagnetventile vorgestellt. Die Steuerung dient zur Stellung des Radbremszylinderdrucks von Kraftfahrzeugen bei fahrdynamischen Regeleingriffen, wie z.B. durch ein ESP oder ein ABS [1;11]. Für den Steuerungsentwurf wird aus einem detaillierten Simulationsmodell des Bremssystems ein vereinfachtes Modell abgeleitet, welches die wesentlichen Nichtlinearitäten des Systems sowie Umgebungseinflüsse (z.B. Temperatur) berücksichtigt. Auf der Grundlage der Gleichungen des vereinfachten Entwurfsmodells werden die Schaltzeiten und weitere charakteristische Zeitintervalle, die das dynamische Verhalten des Ventils beschreiben, durch symbolische Integration oder approximativ mit Hilfe von Taylor-Reihen berechnet. Die so bestimmten Zeitintervalle dienen dann zur Berechnung der Ansteuerzeit des Ventils aus der Solldruckvorgabe für den Bremszylinder und den physikalischen Systemparametern. Die entwickelte Ansteuerung hat sich bei Simulationsstudien als eine leistungsfähige Methode erwiesen und ermöglicht eine im Vergleich zu heutigen Bremssystemen verbesserte Druckstellgenauigkeit.
The nature of the hydroxyapatite-binding site in salivary acidic proline-rich proteins (1979)

Protein A and C, which are major components of the acidic proline-rich proteins in human saliva, were digested, before or after adsorption to hydroxyapatite, with alkaline phosphatase, trypsin, thermolysin and a proteinase preparation from salivary sediment. The results demonstrate that the binding site is located in the proline-poor N-terminal part of the protein, possibly between residues 3 and 25. Phosphoserine is necessary for maximal adsorption of the proteins to hydroxyapatite. When proteins A and C are adsorbed to hydroxyapatite before proteolytic digestion there is a protection of some of the susceptible bonds in the N-terminal part of the proteins and a gradual removal of the proline-rich C-terminal part. Thermolysin can cleave susceptible bonds in the part of the protein that remains bound to hydroxyapatite, but at least some of the resulting peptides are retained on the mineral. Since the ability of the proteins to inhibit hydroxyapatite formation and to bind calcium is located in the N-terminal proline-poor part, it is possible that these activities are retained after proteolytic digestion of the adsorbed proteins.
Silicon Substitution in Oxazine Dyes Yields Near-Infrared Azasiline Fluorophores That Absorb and Emit beyond 700 nm (2018)

Exchanging the bridging oxygen atom in rhodamine dyes with a dimethylsilyl group red-shifts their excitation and emission spectra, transforming orange fluorescent rhodamines into far-red Si-rhodamines. To study the effect of this substitution in other dye scaffolds, synthetic approaches to incorporate silicon into the bridging position of oxazine dyes were developed. The fluorescence of the compact azasiline dyes ASiFluor710 and ASiFluor730 is red-shifted by 57-83 nm from that of Oxazine 1.
Androgen Receptor-dependent Transactivation of Growth Arrest-specific Gene 6 Mediates Inhibitory Effects of Testosterone on Vascular Calcification (2010)

Recent epidemiological studies have found that androgen deficiency is associated with a higher incidence of cardiovascular disease in men. However, little is known about the mechanism underlying the cardioprotective effects of androgens. Here we show the inhibitory effects of testosterone on vascular calcification and a critical role of androgen receptor (AR)-dependent transactivation of growth arrest-specific gene 6 (Gas6), a key regulator of inorganic phosphate (P(i))-induced calcification of vascular smooth muscle cells (VSMC). Testosterone and nonaromatizable androgen dihydrotestosterone inhibited P(i)-induced calcification of human aortic VSMC in a concentration-dependent manner. Androgen inhibited P(i)-induced VSMC apoptosis, an essential process for VSMC calcification. The effects on VSMC calcification were mediated by restoration of P(i)-induced down-regulation of Gas6 expression and a subsequent reduction of Akt phosphorylation. These effects of androgen were blocked by an AR antagonist, flutamide, but not by an estrogen receptor antagonist, ICI 182,780. We then explored the mechanistic role of the AR in Gas6 expression and found an abundant expression of AR predominantly in the nucleus of VSMC and two consensus ARE sequences in the Gas6 promoter region. Dihydrotestosterone stimulated Gas6 promoter activity, and this effect was abrogated by flutamide and by AR siRNA. Site-specific mutation revealed that the proximal ARE was essential for androgen-dependent transactivation of Gas6. Furthermore, chromatin immunoprecipitation assays demonstrated ligand-dependent binding of the AR to the proximal ARE of Gas6. These results indicate that AR signaling directly regulates Gas6 transcription, which leads to inhibition of vascular calcification, and provides a mechanistic insight into the cardioprotective action of androgens.
Pit Growth Study in Al Alloys by the Foil Penetration Technique (2000)

The foil penetration technique was used to study pit growth in AA1100-O and AA2024-T3. Preliminary work on AA1100-O foils of different thicknesses indicated that the pit growth rate increased with increasing applied potential, suggesting that pit growth was not under transport control. Foil penetration experiments were also carried out on AA2024-T3 foils of a given thickness, at open circuit as well as anodic potentials. Dichromate ions and other oxidizing agents were added to some test solutions. Dichromate ions were shown to have little influence on the pit growth rate at controlled anodic potentials, even when added in large concentrations. However, dichromate ions effectively inhibited pitting at open circuit when present in very small amounts. Polarization curves of AA2024-T3 in 1 M NaCl with various additives show a large effect of dichromate ions in the cathodic region and no effect in the anodic region. These observations suggest that chromate (or its reduction product) acts as a cathodic inhibitor. Examination of penetrated samples was performed by optical and scanning electron microscopies, as well as by microradiography.
[Tomographic study in humans of blood flow and oxygen consumption of the brain by continuous inhalation of oxygen 15. Preliminary findings in cerebral ischemic accidents]. (1978)

Le tecniche di Process Mining consentono di modellare, monitorare e migliorare i processi in un'ampia varietà di domini applicativi. Queste tecniche sono oggetto di crescente interesse per la necessità di adeguare i processi di business a contesti sempre più competitivi e in rapida evoluzione. L'articolo fa il punto su questa disciplina, introducendo un insieme di principi guida per la sua applicazione e individuando nuove sfide per il futuro.
Hardware testbed for sidelink transmission of 5G waveforms without synchronization (2016)

This paper details a hardware testbed conceived for studying the impact of the lack of synchronism between transmitters on several 5G waveform candidates, which is of special relevance for car-to-car communications. The experimental results show that a proper fitting of waveforms in a software-defined platform would permit increasing the range of communication between cars without peer-to-peer synchronization, paving the way for the real development of collision avoidance messages.
<title>Error detection in digital neural networks: an algorithm-based approach for inner product protection</title> (1994)

Artificial Neural Networks are an interesting solution for several real-time applications in the area of signal and image processing, in particular since recent advances in VLSI integration technologies allow for efficient hardware realizations. The use of dedicated circuits implementing the neural networks in mission-critical applications requires a high level of protection with respect to errors due to faults to guarantee output credibility and system availability. In this paper, the problem of concurrent error detection in dedicated neural networks is discussed by adopting an algorithm-based approach to check the inner product, i.e., the most of the computation performed in the neural network. Effectiveness and efficiency of this technique is shown and evaluated for the widely-used classes of neural paradigms.
Analysis of Structure and Swelling Behavior of Silk Fibers Treated with a Mixture of Glyoxal and Urethane Resins. (1994)

Fiber structure and swelling behavior of domestic silk fibers (Bombyx mori) treated with a mixture of glyoxal and urethane resins were investigated. The amino acid composition of the hydrolysate solution of the resin treated fibers indicated that the glyoxal monomer reacted with the tyrosine residue. For the glyoxal resin with relatively large number of hydroxyl groups per glyoxal monomer, the fixation of the resin to the amorphous regions of the fibers was promoted and the crystallites with smaller sizes were destroyed. However, if the number of hydroxyl groups was relatively small, the degree of swelling of the amorphous regions decreased although the amount of the resin fixed in the fibers was small. The decrease in the absorption of water by treating the fibers with a mixture of glyoxal and urethane resins was considered to be caused by the crosslinkings formed in the fibers.
Precise localisation of 3p25 breakpoints in four patients with the 3p-syndrome. (1996)

In patients with the 3p-syndrome, hemizygous deletion of 3p25-pter is associated with profound growth failure, characteristic facial features, and mental retardation. We performed a molecular genetic analysis of 3p25 breakpoints in four patients with the 3p- syndrome, and a fifth patient with a more complex abnormality, 46,XY,der(3)t(3;?)(p25.3;?). EBV transformed lymphoblasts from each of the patients were initially characterised using fluorescent in situ hybridisation (FISH) and polymorphic microsatellite analyses. The 3p-chromosome from each patient was isolated from the normal chromosome 3 in somatic cell hybrid lines and subsequently analysed with polymorphic and monomorphic PCR amplifiable markers from 3p25. The analysis clearly shows that all five breakpoints are distinct. Furthermore, we have identified yeast artificial chromosomes that cross the 3p25 breakpoints of all four 3p-patients. Two of the patients were deleted for the von Hippel-Lindau (VHL) tumour suppressor gene, although neither has yet developed evidence of VHL disease. The patient with the most centromeric breakpoint, between D3S1585 and D3S1263, had the most severe clinical phenotype including an endocardial cushion defect that was not observed in any of the four patients who had more telomeric breakpoints. This study should provide useful insights into critical regions within 3p25 that are involved in normal human growth and development.
HETERODYNED ELECTROSTATIC TRANSDUCTION OSCILLATORS EVADE LOW FREQUENCY NOISE ALIASING (2010)

We recently demonstrated a polarization technique that eliminates the frequency drift due to dielectric charge in MEMS oscillators In this work we show that these oscillators are also firstorder insensitive to low-frequency voltage noise, with potential for significant positive impact on predicted close-to-carrier phase noise performance. Close-to-carrier noise also determines the limits of some resonant sensor applications [2, 3].
Supplementary Table S1 from Cancer-Specific Production of N-Acetylaspartate via NAT8L Overexpression in Non–Small Cell Lung Cancer and Its Potential as a Circulating Biomarker (2023)

&lt;p&gt;194 non-redundant compounds detected in HCC4017 or HBEC30KT cells.&lt;/p&gt;
Probing confined interfacial excitations in buried layers by Brillouin light scattering (2001)

Brillouin light scattering from silicon oxynitride films grown on GaAs reveals a low frequency elastic wave excitation at frequencies lying below that of the Rayleigh surface wave. This mode, identified as an excitation localized by the interface, arises from the presence of a soft, thin transition layer between the film and substrate. Observations of this low frequency excitation offer a previously unexplored approach to characterize, non-destructively, the properties of buried interfaces.
201. INTERPRETATION OF INDIUM-111 PLATELET SCINTIGRAPHY FOR DEEP VEIN THROMBOSIS (1984)

Sostman, D.; Pope, C. F.; Smith, E. O.; Rapoport, S.; Glickman, M.; Zaret, B. L.; Greenspan, R. H. M.D. Author Information
Multi-Physics Multi-Plateau Reaction Model for LiSi/FeS2 Batteries. (2019)

Abstract not provided.
Cartographie du melon à l'aide de marqueurs moléculaires et de gènes de résistance aux maladies (1995)

* INRA, Centre de Recherche d'Avignon, URD, Domaine St Paul, Site Agroparc, 84914 Avignon cedex 9 Diffusion du document : INRA, Centre de Recherche d'Avignon, URD, Domaine St Paul, Site Agroparc, 84914 Avignon cedex 9 <br/>Événement(s) lié(s) : - Groupe de travail; Méribel (FRA) - (1995-03-20 - 1995-03-24)
Mutation within the herpes simplex virus DNA polymerase gene conferring resistance to (R)-9-(3,4-dihydroxybutyl)guanine (1986)

Five herpes simplex virus mutants known or presumed to contain mutations in their DNA polymerase genes conferring resistance to acyclovir and arabinosyladenine also proved to exhibit some degree of resistance to (R)-9-(3,4-dihydroxybutyl)guanine (buciclovir). For one mutant, a buciclovir resistance mutation was mapped to a region of the viral DNA polymerase gene proposed to encode the deoxynucleoside 5'-triphosphate binding domain. These data implicate the viral polymerase as a target of buciclovir action that contributes to its antiviral selectivity.
Reconsidering the Mechanism of Polyglutamine Peptide Aggregation (2007)

There are at least nine neurodegenerative diseases associated with proteins that contain an unusually expanded polyglutamine domain, the best known of which is Huntington's disease. In all of these diseases, the mutant protein aggregates into neuronal inclusions; it is generally, although not universally, believed that protein aggregation is an underlying cause of the observed neuronal degeneration. In an effort to examine the role of polyglutamine in facilitating protein aggregation, investigators have used synthetic polyglutamine peptides as model systems. Analysis of kinetic data led to the conclusions that aggregation follows a simple nucleation-elongation mechanism characterized by a significant lag time, during which the peptide is monomeric, and that the nucleus is a monomer in a thermodynamically unfavorable conformation [Chen, S. M., et al. (2002) Proc. Natl. Acad. Sci. U.S.A. 99, 11884-11889]. We re-examined this hypothesis by measuring the aggregation kinetics of the polyglutamine peptide K2Q23K2, using sedimentation, static and dynamic light scattering, and size exclusion chromatography. Our data show that during the lag time in sedimentation kinetics, there is substantial organization of the peptide into soluble linear aggregates. These aggregates have no regular secondary structure as measured by circular dichroism but have particle dimensions and morphologies similar to those of mature insoluble aggregates. The soluble aggregates constitute approximately 30% of the total peptide mass, form rapidly, and continue to grow over a period of hours to days, eventually precipitating. Once insoluble aggregates form, loss of monomer from the solution phase continues. Our data support an assembly mechanism for polyglutamine peptide more complex than that previously proposed.
Learning theory applied to Sigmoid network classification of protein biological function using primary protein structure (2003)

Recently, Valiant’s Probably Approximately Correct (PAC) learning theory
has been extended to learning m-dependent data. With this extension, training
data set size for sigmoid neural networks have been bounded without underlying assumptions
for the distribution of the training data. These extensions allow learning
theory to be applied to training sets which are definitely not independent samples of
a complete input space. In our work, we are developing length independent measures
as training data for protein classification. This paper applies these learning theory
methods to the problem of training a sigmoid neural network to recognize protein
biological activity classes as a function of protein primary structure. Specifically, we
explore the theoretical training set sizes for classifiers using the full amino acid sequence
of the protein as the training data and using length independent measures as
the training data. Results show bounds for training set sizes given protein size limits
for the full sequence input compared to bounds for input that is sequence length
independent.