gebhart/patrepeval huggingface dataset:
Real Time Estimation and Control of Oxide-Etch Rate Distribution Using Plasma Emission Distribution Measurements (2008)

We studied real-time estimation and automatic control of etch-rate distribution in order to develop next-generation oxide etching techniques that will have improved reliability and reproducibility when used in mass production processes. We specifically investigated the relationship between plasma emission intensity (PEI) distribution detected by silicon photodiodes and oxide etch-rate distribution. We found that there was a strong correlation (correlation coefficient = 0.988) between the uniformity of oxide etch-rate distribution and relative PEI distribution. We also found that relative changes in oxide etch-rate uniformity of ±1% can be detected in real time by measuring PEI distribution. We then demonstrated that self-adjustments of oxide etch-rate distribution are possible by using feedback based on the monitoring PEI distribution to control magnetic field conditions. Moreover, we demonstrated that monitoring PEI distribution can be used to observe fast phenomena that occur in the order of milliseconds during the plasma transition process. These phenomena are related to charging damage, such as plasma ignition and disappearance.
STAT3 in Epithelial Cells Regulates Inflammation and Tumor Progression to Malignant State in Colon (2013)

Chronic inflammation is an important risk factor for the development of colorectal cancer; however, the mechanism of tumorigenesis especially tumor progression to malignancy in the inflamed colon is still unclear. Our study shows that epithelial signal transducer and activator of transcription 3 (STAT3), persistently activated in inflamed colon, is not required for inflammation-induced epithelial overproliferation and the development of early-stage tumors; however, it is essential for tumor progression to advanced malignancy. We found that one of the mechanisms that epithelial STAT3 regulates in tumor progression might be to modify leukocytic infiltration in the large intestine. Activation of epithelial STAT3 promotes the infiltration of the CD8+ lymphocyte population but inhibits the recruitment of regulatory T (Treg) lymphocytes. The loss of Stat3 in epithelial cells promoted the expression of cytokines/chemokines including CCL19, CCL28, and RANTES, which are known to be able to recruit Treg lymphocytes. Linked to these changes was the pathway mediated by sphingosine 1-phosphate receptor 1 and sphingosine 1-phosphate kinases, which is activated in colonic epithelial cells in inflamed colon with functional STAT3 but not in epithelial cells deleted of STAT3. Our data suggest that epithelial STAT3 plays a critical role in inflammation-induced tumor progression through regulation of leukocytic recruitment especially the infiltration of Treg cells in the large intestine.
On the Structure of the Protein Molecule. (1946)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOn the Structure of the Protein Molecule.N. Troensegaard, E. Munksgaard, H. Millford, and H. B. VickeryCite this: J. Phys. Chem. 1946, 50, 3, 284–285Publication Date (Print):March 1, 1946Publication History Published online1 May 2002Published inissue 1 March 1946https://doi.org/10.1021/j150447a013RIGHTS & PERMISSIONSArticle Views16Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (185 KB) Get e-Alerts
Simple, rapid, and effective method of producing aortocaval shunts in the rat (1990)

STUDY OBJECTIVE - The aim of the study was to develop a new procedure to produce abdominal aortocaval shunts in the rat without vascular microsurgery. PROCEDURE - The inferior vena cava and abdominal aorta were exposed by laparotomy. The aorta was punctured caudal to the left renal artery with an 18 gauge disposable needle which was advanced into the vessel, perforating the adjacent wall between aorta and vena cava and penetrating the latter. A bulldog vascular clamp was placed across the aorta cephalic to the puncture, the needle was withdrawn, and the aortic puncture point was sealed with a drop of cyanoacrylate glue. The clamp was removed 30 s later. Patency of the shunt was verified visually by swelling of the vena cava and admixture of arterial and venous blood. No local haemorrhages were seen. The laporatomy was then closed. The procedure takes less than 10 min. RESULTS - Of 11 rats which received this procedure, only one died within 24 h. All the other animals were killed 4 weeks after operation. Nine of these 10 animals had developed cardiac hypertrophy of about the same magnitude. There were no changes in sham operated controls. CONCLUSIONS - This is a reproducible, simple and rapid method of developing high output heart failure and cardiac hypertrophy in the rat which could be useful in many laboratories.
Differential Mobility Spectrometry Applications in Homeland Security, Clinical Diagnostics and Drug Discovery (2006)

There is an urgent need for miniaturized sensors that can rapidly, accurately, and specifically detect extremely low concentrations of chemical and biological materials. Such technologies impact many areas including public health, drug development and national defense. Along with other research groups in industry and academia, we are developing new microfabricated sensors based on differential mobility spectrometry - also known as high field asymmetric ion mobility spectrometry. These sensors are suitable for rapid diagnosis of various pulmonary diseases and respiratory pathogens, and they may also be used for explosives and narcotics detection when configured and tuned to detect different chemical signatures. Similarly, we are also applying variations on this technology for the early detection of biological weapons agents. Given the extensive work being performed by many different research groups in many different specialties, there is now a need for a coherent and exhaustive look at the similarities and differences of detection in medical, pharmaceutical, defense and security applications and how these may influence system level designs.
Resurfacing Capitate Pyrocarbon Implant versus Proximal Row Carpectomy Alone: A Comparative Study to Evaluate the Role of Capitate Prosthetic Resurfacing in Advanced Carpal Collapse (2017)

Therapeutic, III.
An 80-Gb/s 300-GHz-Band Single-Chip CMOS Transceiver (2019)

A single-chip CMOS transceiver (TRX) capable of wireless data rates up to 80 Gb/s using part of frequencies (252–279 GHz) covered by IEEE Std 802.15.3d is presented. The TRX chip operates in either transmitter (TX) or receiver (RX) mode at frequencies comparable to <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">${f_{\mathrm {max}}}$ </tex-math></inline-formula> of the NMOSFET. The TX part adopts mixer-last architecture with four-way power combining using a ring circuit called a double-rat-race. The RX part adopts fundamental-mixer-first direct-conversion architecture. In the RX mode, the TX serves as an LO multiplier chain, which conventionally accounted for a significant part of the RX die area. The double-rat-race, having an improved design than the original one, integrates the TX and RX and also rejects unwanted harmonics generated by the frequency-doubler-based upconversion mixer. Low-loss, low-characteristic-impedance transmission lines are used extensively to combat losses. The TRX was fabricated using a 40-nm CMOS process. The saturated output power of the TX is −1.6 dBm at 265.68 GHz. The mean single-sideband noise figure (SSB NF) of the RX is 22.9 dB. The TX mode and the RX mode consume dc power of 890 and 897 mW, respectively. A wireless data rate of 80 Gb/s between a pair of TRX chips is demonstrated with 16QAM over a distance of 3 cm.
Chicken Ovalbumin Upstream Promoter-Transcription Factor Interacts with Estrogen Receptor, Binds to Estrogen Response Elements and Half-Sites, and Inhibits Estrogen-induced Gene Expression (1997)

Chicken ovalbumin upstream promoter-transcription factor (COUP-TF) was identified as a low abundance protein in bovine uterus that co-purified with estrogen receptor (ER) in a ligand-independent manner and was separated from the ER by its lower retention on estrogen response element (ERE)-Sepharose. In gel mobility shift assays, COUP-TF bound as an apparent dimer to ERE and ERE half-sites. COUP-TF bound to an ERE half-site with high affinity, Kd = 1.24 nM. In contrast, ER did not bind a single ERE half-site. None of the class II nuclear receptors analyzed, i.e. retinoic acid receptor, retinoid X receptor, thyroid receptor, peroxisome proliferator-activated receptor, or vitamin D receptor, were constituents of the COUP-TF.DNA binding complex detected in gel mobility shift assays. Direct interaction of COUP-TF with ER was indicated by GST "pull-down" and co-immunoprecipitation assays. The nature of the ER ligand influenced COUP-TF-ERE half-site binding. When ER was liganded by the antiestrogen 4-hydroxytamoxifen (4-OHT), COUP-TF-half-site interaction decreased. Conversely, COUP-TF transcribed and translated in vitro enhanced the ERE binding of purified estradiol (E2)-liganded ER but not 4-OHT-liganded ER. Co-transfection of ER-expressing MCF-7 human breast cancer cells with an expression vector for COUP-TFI resulted in a dose-dependent inhibition of E2-induced expression of a luciferase reporter gene under the control of three tandem copies of EREc38. The ability of COUP-TF to bind specifically to EREs and half-sites, to interact with ER, and to inhibit E2-induced gene expression suggests COUP-TF regulates ER action by both direct DNA binding competition and through protein-protein interactions.
Increased thalamic inhibition in the absence seizure prone DBA/2J mouse (2008)

Genetic background plays a significant role in producing variable seizure outcomes in patients and animal models. The neurobiological mechanism underlying this heterogeneity is not clear. Here we compare GABAergic synaptic properties within the thalamocortical circuit of two commonly used inbred mice strains, the C57B/6 and spike-and-wave discharge (SWD) prone DBA/2J. Differences between the strains occur in amplitude, kinetics, and frequency of miniature inhibitory postsynaptic currents (mIPSCs) in a region-specific manner. The biggest difference in synaptic inhibition was seen in the thalamus where DBA/2J mice showed a doubling of mIPSC frequency when compared to C57B/6. EEG analysis revealed higher power in the 6-12 Hz band during non-rapid eye movement sleep in DBA/2J mice. Increased susceptibility of the DBA2/J strain to develop SWDs and increase in the 6-12 Hz EEG power may be due to a hypersynchronous ventrobasal thalamus as a consequence of increased GABAergic input.
A la recherche d'inhibiteurs de la chymase cardiaque humaine (2002)

Climate change will have significant impacts on human health, and urban populations are expected to be highly sensitive. The health risks from climate change in cities are compounded by rapid urbanization, high population density, and climate-sensitive built environments. Local governments are positioned to protect populations from climate health risks, but it is unclear whether municipalities are producing climate-adaptive policies. In this article, we develop and apply systematic methods to assess the state of public health adaptation in 401 urban areas globally with more than 1 million people, creating the first global baseline for urban public health adaptation. We find that only 10% of the sampled urban areas report any public health adaptation initiatives. The initiatives identified most frequently address risks posed by extreme weather events and involve direct changes in management or behavior rather than capacity building, research, or long-term investments in infrastructure. Based on our characterization of the current urban health adaptation landscape, we identify several gaps: limited evidence of reporting of institutional adaptation at the municipal level in urban areas in the Global South; lack of information-based adaptation initiatives; limited focus on initiatives addressing infectious disease risks; and absence of monitoring, reporting, and evaluation.
Adult-onset Krabbe disease with homozygous T1853C mutation in the galactocerebrosidase gene (1997)

A 51-year-old woman developed a slowly progressive spastic paraparesis and diminished vibration sense beginning at age 38. Intellectual capacity was normal. Krabbe disease was confirmed by markedly reduced leukocyte galactocerebrosidase (GALC) activity, typical inclusions in Schwann cell cytoplasm, and an identification of the homozygous point mutation T1835C (Leu618Ser) in the GALC gene. T2-weighted MRI of the brain showed symmetric high-signal-intensity lesions in the bilateral frontoparietal white matter, the centrum semiovale, and the posterior limb of the internal capsule with sparing of the periventricular white matter. This case is unusual because of the late onset, protracted clinical course, and MRI findings of demyelination confined to the corticospinal tracts.
Targeting Receptor Tyrosine Kinase MET in Cancer: Small Molecule Inhibitors and Clinical Progress (2013)

The HGF/MET signaling pathway is critical in mediating a wide range of normal physiological functions including embryological development, wound healing, and tissue regeneration. Aberrant activation of the pathway has frequently been found in human cancers via protein overexpression, mutation, gene amplification, and also paracrine or autocrine up-regulation. In addition, the activation of HGF/MET signaling confers resistance to the effects of cancer treatments. Therefore, inhibition of the HGF/MET signaling pathway has great potential for therapeutic intervention in cancer. Currently, there are three approaches toward modulating HGF/MET signaling in human clinical studies of cancer: anti-HGF monoclonal antibodies, MET monoclonal antibodies, and small molecule MET inhibitors. Preliminary clinical benefit from inhibition of HGF or MET has been reported. This Perspective will provide an overview of the HGF/MET signaling pathway in cancer and then will review the development of small molecule MET inhibitors and their progress in clinical applications.
Advanced technologies and diagnostic spin-outs: an interview with Carl Borrebaeck (2015)

Interview with Professor Carl Borrebaeck DSc by Claire Raison (Commissioning Editor) Professor Carl Borrebaeck DSc, is the Director of CREATE Health (Lund, Sweden), a translational cancer center, previous Vice President of Lund University and specializes in immunotechnology, diagnostics and treatments for cancer. He has had remarkable success in co-founding collaborative working groups and related spin-out companies based in Lund. Professor Borrebaeck also serves as a member of the editorial advisory board for Expert Review of Molecular Diagnostics. Here, Professor Borrebaeck talks to Expert Review of Molecular Diagnostics about his experience and what is next for cutting-edge technology in cancer diagnostics.
Response-Based Estimation of Sea State Parameters (2007)

Reliable estimation of the on-site sea state parameters is essential to decision support systems for safe navigation of ships. The sea state parameters can be estimated by Bayesian Modelling which uses complex-valued frequency response functions (FRF) to estimate the wave spectrum on the basis of measured ship responses. It is therefore interesting to investigate how the filtering aspect, introduced by FRF, affects the final outcome of the estimation procedures. The paper contains a study based on numerical generated time series, and the study shows that filtering has an influence on the estimations, since high frequency components of the wave excitations are not estimated as accurately as lower frequency components. Moreover, the paper investigates how the final outcome of the Bayesian Modelling is influenced by the accuracy of the FRF. Thus, full-scale data is analysed by use of FRF calculated by a 3-D time domain code and by closed-form (analytical) expressions, respectively. Based on comparisons with wave radar measurements and satellite measurements it is seen that the wave estimations based on closed-form expressions exhibit a reasonable energy content, but the distribution of energy appears to be incorrect.
Photoluminescence of nucleic bases, DNA, and biological objects (2010)

Photoluminescence spectra of nucleic bases, DNA, and two types of microorganisms, excited by the fourth harmonic radiation of the YAG:Nd3+ laser with a wavelength of 266 nm, were studied. It was shown that photoluminescence in these biological objects is very efficiently excited due to the closeness of the exciting radiation wavelength to the fundamental absorption edge of an analyzed object.
Scavenging roles of chemokine receptors: chemokine receptor deficiency is associated with increased levels of ligand in circulation and tissues (2008)

In vitro studies have implicated chemokine receptors in consumption and clearance of specific ligands. We studied the role that various signaling chemokine receptors play during ligand homeostasis in vivo. We examined the levels of ligands in serum and CNS tissue in mice lacking chemokine receptors. Compared with receptor-sufficient controls, Cx3cr1(-/-) mice exhibited augmented levels of CX3CL1 both in serum and brain, and circulating levels of CXCL1 and CXCL2 were increased in Cxcr2(-/-) mice. CCR2-deficient mice showed significantly increased amounts of circulating CCL2 compared with wild-type mice. Cxcr3(-/-) mice revealed increased levels of circulating and brain CXCL10 after experimental autoimmune encephalomyelitis (EAE) induction. CCR2-deficient peripheral blood and resident peritoneal cells exhibited reduced binding capacity and biologic responses to the CCR1 ligand CCL3, suggesting that elevated levels of CCR2 ligands had down-regulated CCR1. The results indicate that signaling chemokine receptors clear chemokines from circulation and tissues. These homeostatic functions of signaling chemokine receptors need to be integrated into safety and efficacy calculations when considering therapeutic receptor blockade.
Electrostatic energy harvester based on multiple variable capacitors (2016)

This paper presents an electrostatic harvester of vibration energy based on multiple variable capacitors. Conventional electrostatic energy harvesters rely on a single variable capacitor working when driven by vibrations of sufficient amplitude and frequency. The proposed harvester is suitable for applications with low vibration amplitude and frequency because it can start in lower vibration conditions without increasing the size of the device. A harvester prototype based on four variable capacitors was developed, and its performance was measured and analyzed.
Optical Coherence Tomography Angiography in a Patient with Optic Atrophy After Non-arteritic Anterior Ischaemic Optic Neuropathy (2016)

A 75-year-old female noticed a lower visual field (VF) defect in the right eye. A diagnosis of non-arteritic anterior ischaemic optic neuropathy (NAION) was made. The lower VF defect in the right eye did not change after onset. Optical coherence tomography (OCT) angiograms on the disc and the macula showed decreased retinal perfusion in the upper retina of the right eye. Retinal nerve fibre layer loss and ganglion cell complex loss in the upper retina were also seen in the right eye. OCT angiography could non-invasively detect the decrease of the retinal perfusion due to NAION.
Micropatterning of Functional Conductive Polymers with Multiple Surface Chemistries in Register (2012)

A versatile procedure is presented for fast and efficient micropatterning of multiple types of covalently bound surface chemistry in perfect register on and between conductive polymer microcircuits. The micropatterning principle is applied to several types of native and functionalized PEDOT (poly(3,4-ethylenedioxythiophene)) thin films. The method is based on contacting PEDOT-type thin films with a micropatterned agarose stamp containing an oxidant (aqueous hypochlorite) and applying a nonionic detergent. Where contacted, PEDOT not only loses its conductance but is entirely removed, thereby locally revealing the underlying substrate. Surface analysis showed that the substrate surface chemistry was fully exposed and not affected by the treatment. Click chemistry could thus be applied to selectively modify re-exposed alkyne and azide functional groups of functionalized polystyrene substrates. The versatility of the method is illustrated by micropatterning cell-binding RGD-functionalized PEDOT on low cell-binding PMOXA (poly(2-methyl-2-oxazoline)) to produce cell-capturing microelectrodes on a cell nonadhesive background in a few simple steps. The method should be applicable to a wide range of native and chemically functionalized conjugated polymer systems.
Solving Optimization Problems Among Selfish Agents (2000)

v 1 Introduction 1 1.1 Background . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 1.1.1 Game theory . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 1.1.2 Mechanism Design . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 1.1.3 Some fundamental concepts of theoretical computer science . . . . . . . . . . 6 1.1.4 Game theoretic considerations in computer science . . . . . . . . . . . . . . . 8 1.2 Overview of the results . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 1.2.1 Algorithmic Mechanism Design . . . . . . . . . . . . . . . . . . . . . . . . . . 11 1.2.2 Computationally Feasible VCG Mechanisms . . . . . . . . . . . . . . . . . . . 12 2 Algorithmic Mechanism Design 13 2.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 2.1.1 Motivation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 2.1.2 This Work ....
Effects of high pressure on anhydrous milk fat crystallization in emulsion (2009)

Anhydrous milk fat crystallization was compared either in bulk phase or in oil in water emulsion by studying melting curves obtained by calorimetry measurements. Emulsions were submitted to a high pressure (HP) treatment (200 MPa/10 min). An aging period of 72 h was required to obtain the highest amount of crystallized fat at 4 °C. Emulsification promoted the crystallization of low melting point (LMP) triglycerides. The effect of HP on anhydrous milk fat crystallization depended on the aging time. For short aging periods (30 min and 1 h), HP treatment favored the crystallization of LMP triglycerides, thus amplifying the effect of emulsification compared with the crystallization in bulk phase. However, for a long aging time, &lt;i&gt;i.e.&lt;/i&gt; 48 h, the amounts of crystallized matter in emulsion with or without HP treatment were comparable. This result was interpreted in terms of a different polymorphic form crystallizing under HP.