gebhart/patrepeval huggingface dataset:
Elevation of Circulating and Ventricular Adrenomedullin in Human Congestive Heart Failure (1995)

The present study demonstrates that plasma concentration of ADM is increased in patients with CHF and that ADM is present in the human heart. ADM immunoreactivity is markedly increased in the failing human ventricle, suggesting that ventricular ADM expression may be influenced by the circumstances associated with CHF. This supports a potential role for this newly identified vasoactive and natriuretic peptide, ADM, in the neurohumoral activation that characterizes human CHF.
Screenwriting: A Manual (2000)

Covering all forms of screenwriting, this is a wide-ranging and accessbile guide to industry practices and principles. While providing a comprehensive and considered approach to presenting work, it allows for a great deal of creative freedom. With script extracts, original storyboards, and narrative ideas for multimedia, the book offers concrete examples of successful and expressive screenwriting within the described production formats. It also contains exercises for generating and shaping the various elements of a script, an appendix on copyright and other legal issues, and a glossary of terms.
Weighted Least Square Filter for Improving the Quality of Depth Map on FPGA (2022)

This paper proposes a post-filtering system for improving the quality of depth maps for 3D projection on FPGA. We propose to implement the Weighted Least Square (WLS) filter on Field-programmable Gate Array (FPGA), which can predict the disparities, which cannot be measured, by using the values of the neighboring pixels. In our design, we optimized the architecture of WLS filter at the algorithm level. For hardware acceleration, we use the High-Level Synthesis (HLS) description to accelerate the algorithm. To break through the bottleneck brought by the limited memory resources on FPGA, we used UltraScale Architecture Memory Resources (URAM) on board and reduced memory consumption of Block RAMs (BRAM) from 140% to 80%. Through our approach, we can improve the quality of the depth map on the FPGA named M-KUBOS. And, the WLS filter can smooth the depth map with 130 MHz operational frequency on M-KUBOS at the speed of 10 frames per second (FPS), which achieves a 76.43% performance acceleration compared to the software execution on the ARM Cortex A9 at 1.2 GHz clock.
Immunoblot interpretation criteria for serodiagnosis of early Lyme disease (1995)

We monitored the antibody responses of 55 treated patients with early Lyme disease and physician-documented erythema migrans. Six sequential serum samples were obtained from patients before, during, and until one year after antibiotic therapy and analyzed by in-house enzyme-linked immunosorbent (ELISA) and immunoblot assays. An immunoblot procedure utilizing a gradient gel and an image analysis system was developed. A relational database management system was used to analyze the results and provide criteria for early disease immunoblot interpretation. Recommended criteria for the immunoglobulin M (IgM) immunoblot are the recognition of two of three proteins (24, 39, and 41 kDa). The recommended criteria for a positive IgG immunoblot are the recognition of two of five proteins (20, 24 [> 19 intensity units], 35, 39, and 88 kDa). Alternatively, if band intensity cannot be measured, the 22-kDa protein can be substituted for the 24-kDa protein with only a small decrease in sensitivity. Monoclonal antibodies were used to identify all these proteins except the 35-kDa protein. With the proposed immunoblot interpretations, the sequential serum samples were examined. At visit 1, the day of diagnosis and initiation of treatment, 54.5% of the serum samples were either IgM or IgG positive. The peak antibody response, with 80% of the serum samples positive, occurred at visit 2, 8 to 12 days into treatment. The sensitivities of the IgM and IgG immunoblot for detecting patients that were seropositive into the study period were 58.5 and 54.6%, respectively, at visit 1 and 100% at visit 2. Twenty percent of the patients remained seronegative throughout the study. The specificities of the IgM and IgG immunoblots were 92 to 94% and 93 to 96%, respectively. The IgM immunoblot and ELISA were similar in sensitivities, whereas the IgG immunoblot had greater sensitivity than the IgG ELISA (P = 0.006).
[Al5(tBu)5(.mu.3-O)2(.mu.3-OH)2(.mu.-OH)2(.mu.-O2CPh)2]: A Model for the Interaction of Carboxylic Acids with Boehmite (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT[Al5(tBu)5(.mu.3-O)2(.mu.3-OH)2(.mu.-OH)2(.mu.-O2CPh)2]: A Model for the Interaction of Carboxylic Acids with BoehmiteYoshihiro Koide and Andrew R. BarronCite this: Organometallics 1995, 14, 8, 4026–4029Publication Date (Print):August 1, 1995Publication History Published online1 May 2002Published inissue 1 August 1995https://pubs.acs.org/doi/10.1021/om00008a060https://doi.org/10.1021/om00008a060research-articleACS PublicationsRequest reuse permissionsArticle Views238Altmetric-Citations69LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
A comparative analysis of total serum miRNA profiles identifies novel signature that is highly indicative of metastatic melanoma: a pilot study (2013)

This approach is independent of tumor heterogeneity and is expected to have superior biomarker performances.
Building User Interfaces with Piu (2020)

This chapter elaborates on Piu, the object-oriented user interface framework that uses the Poco renderer to draw and simplifies the process of creating sophisticated user interfaces. The chapter provides an overview of how Piu works and introduces its key capabilities through a series of examples.
Genetic Variation in Three Candidate Genes and Nicotine Dependence, Withdrawal and Smoking Cessation in Hospitalized Patients (2010)

This study confirms the reported association of the CHRNA3 locus with nicotine dependence and shows the involvement of two independent DRD2 polymorphisms in nicotine dependence.
Selective Separation of Similarly Sized Proteins with Tunable Nanoporous Block Copolymer Membranes (2012)

An integral asymmetric membrane was fabricated in a fast and one-step process by combining the self-assembly of an amphiphilic block copolymer (PS-b-P4VP) with nonsolvent-induced phase separation. The structure was found to be composed of a thin layer of densely packed highly ordered cylindrical channels with uniform pore sizes perpendicular to the surface on top of a nonordered sponge-like layer. The as-assembled membrane obtained a water flux of more than 3200 L m(-2) h(-1) bar(-1), which was at least an order of magnitude higher than the water fluxes of commercially available membranes with comparable pore sizes, making this membrane particularly well suited to size-selective and charge-based separation of biomolecules. To test the performance of the membrane, we conducted diffusion experiments at the physiological pH of 7.4 using bovine serum albumin (BSA) and globulin-γ, two proteins with different diameters but too close in size (2-fold difference in molecular mass) to be efficiently separated via conventional dialysis membrane processes. The diffusion rate differed by a factor of 87, the highest value reported to date. We also analyzed charge-based diffusive transport and separation of two proteins of similar molecular weight (BSA and bovine hemoglobin (BHb)) through the membrane as a function of external pH. The membrane achieved a selectivity of about 10 at pH 4.7, the isoelectric point (pI) of BSA. We then positively charged the membrane to improve the separation selectivity. With the modified membrane BSA was completely blocked when the pH was 7.0, the pI of BHb, while BHb was completely blocked at pH 4.7. Our results demonstrate the potential of our asymmetric membrane to efficiently separate biological substances/pharmaceuticals in bioscience, biotechnology, and biomedicine applications.
Association of GSK3β Polymorphisms With Brain Structural Changes in Major Depressive Disorder (2009)

The GSK3beta gene may have a role in determining regional GM volume differences of the right hippocampus and bilateral superior temporal gyri. The association between genotype and brain structure was specific to the patients with MDD, suggesting that GSK3beta genotypes might interact with MDD status. We speculate that this is a consequence of regional neocortical, glial, or neuronal growth or survival. In considering core cognitive features of MDD, the association of GSK3beta polymorphisms with structural variation in the temporal lobe and hippocampus is of particular interest in the context of other evidence for structural and functional abnormalities in the hippocampi of patients with MDD.
A modular manipulator system using rotary joints toward helping the elderly and the handicapped (2014)

At present, the manipulator for the elderly and disabled has the shortcomings of long production cycle, poor versatility and cannot meet the requirements of individual differences. The modular idea is presented to the design of manipulator system. A rotary joint module is developed with the advantages of small size, light weight and large torque. It integrates mechanical structure, drive, control and communication modules and can be combined into various manipulators with different configurations on demand. A distributed control system based on industrial Ethernet and CAN bus is built using a hierarchical modular structure. It can adapt to a variety of modular manipulators characterized by low stiffness and difficulty of control. Toward assisting the elderly and disabled, a 6-DOF manipulator is assembled by utilizing 6 modular rotary joints. An impedance controller is designed based on the position force control strategies. A drawer-pulled experiment is carried out with the compliance control. Experimental results verify that the modular manipulator presented is qualified to assist the elderly and the handicapped with daily operations safely.
Cloning of a cDNA Encoding 3-Ketoacyl-Acyl Carrier Protein Synthase III from Arabidopsis (1994)

The initial step of fatty acid biosynthesis in both plants and Escherichia coli is the condensation of malonyl-acyl carrier protein with acetyl-COA, a reaction that is catalyzed by KAS 111 (Jackowski and Rock, 1987; Jackowski et al., 1989; Jaworski et al., 1989; Clough et al., 1992). In E. coli, KAS 111 has been implicated as a site of regulation for de novo fatty acid synthesis (Jackowski and Rock, 1987; Jackowski et al., 1989). At present, the regulation of fatty acid biosynthesis has not been clearly delineated in plants. Alteration of KAS 111 expression in Arabidopsis by sense and antisense constructs will help elucidate its regulatory role in vivo. The first plant cDNA clone of KAS 111 was recently isolated from spinach (Tai and Jaworski, 1993). The spinach clone showed a high degree of amino acid identity to the E. coli KAS 111 (Tsay et al., 1992) and the putative KAS I11 from Porphyra umbilicalis (red alga) (Reith, 1993), but no similarity to clones of other KAS isozymes from either plants or E. coli. We have isolated an Arabidopsis KAS 111 cDNA clone using the spinach clone as a heterologous probe (Table I). An Arabidopsis cDNA library was screened using moderatestringency conditions with a radiolabeled 612-bp probe generated from the spinach cDNA clone using PCR. Positive X clones were excised into plasmids and rescreened. One of the putative KAS I11 clones showed a strong positive signal in the second screening, and the initial sequencing of the clone revealed a high sequence identity to the 3‘ end of the spinach KAS I11 clone. The full-length clone was sequenced on both strands with customized primers. The Arabidopsis cDNA clone of KAS I11 contains a single open reading frame of 1215 bp encoding a polypeptide that has 71.8% identity to the deduced amino acid sequence of spinach KAS 111. Its active site Cys was identified at position 179 by comparing conserved sequences near the active site of other KAS 111 proteins. The highest degree of homology to spinach KAS 111 was observed near the C tenninus of the peptide (84.9% identity at the residues 300-405), whereas the N tenninus shows more divergence (50% identity at the residues 1-lOO), mainly due to the transit peptide sequence.
Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway (2013)

SCD1 (stearoyl-coenzyme A desaturase 1) is an endoplasmic reticulum-bound enzyme that catalyzes the formation of the first double bond at the cis-Δ9 position of saturated fatty acids (SFA) to form monounsaturated fatty acids (MUFA). Increasing evidence indicates that autophagy plays an important role in regulating lipid metabolism, while little is known about whether key enzymes of lipogenesis like SCD1 can regulate autophagy. In this study, we examined the role of SCD1 in autophagy using the tsc2(-/-) mouse embryonic fibroblasts (MEFs) possessing constitutively active MTORC1 as a cellular model. We found that mRNA and protein levels of SCD1 are significantly elevated in the tsc2(-/-) MEFs compared with Tsc2(+/+) MEFs, resulting in significant increases in levels of various lipid classes. Furthermore, inhibition of SCD1 activity by either a chemical inhibitor or genetic knockdown resulted in an increase of autophagic flux only in the tsc2(-/-) MEFs. Induction of autophagy was independent of MTOR as MTORC1 activity was not suppressed by SCD1 inhibition. Loss of phosphorylation on AKT Ser473 was observed upon SCD1 inhibition and such AKT inactivation was due to disruption of lipid raft formation, without affecting the formation and activity of MTORC2. Increased nuclear translocation of FOXO1 was observed following AKT inactivation, leading to increased transcription of genes involved in the autophagic process. The tsc2(-/-) MEFs were also more susceptible to apoptosis induced by SCD1 inhibition and blockage of autophagy sensitized the cell death response. These results revealed a novel function of SCD1 on regulation of autophagy via lipogenesis and the lipid rafts-AKT-FOXO1 pathway.
Scale-Only Tomlinson-Harashima Precoding (2009)

With the introduction of a dither sequence and scaling factors, dithered Tomlinson-Harashima precoding (THP) has shown to outperform conventional spatial THP in multi-user MIMO systems. Through a careful analysis of dithered THP, this paper exhibits that it is not only possible, but also beneficial, to eliminate the dither sequence and develop efficient scale-only THP, and the key is to resolve the scaling factors. By capturing the dependency of the interference level on the scaling factors through a closed-form piece-wise function, we formulated a new method to optimize the scaling factors. We present that the new scale-only THP is not only simpler, but also performs better. As much as 1 dB of performance gain is observed at the low signal-to-noise region.
Influence of Synthetic and Processing Parameters on the Surface Area, Speciation, and Particle Formation in Copper Oxide/Silica Aerogel Composites (2003)

A systematic study of the effects of pH, precursor salt, and temperature on the surface area, particle size, and copper speciation in 3 wt % CuO in silica aerogels and xerogels has been conducted. The materials were synthesized by copolymerization sol−gel reactions, followed by either supercritical solvent extraction using CO2 (aerogels) or conventional drying (xerogels) and annealing in air. Among the six different copper precursors examined, copper(II) acetate was found to be the best in terms of its stability, solubility, and binding capacity of copper in the silica matrix. Aerogels prepared with copper(II) acetate were found to have considerably higher surface areas than the corresponding xerogels, and the observed formation of CuO particles occurred at higher temperatures (900 vs 650 °C, by TEM analysis). X-ray diffraction of gels annealed at 900 °C likewise revealed the presence of nanocrystalline CuO, with larger particles observed in acid-catalyzed aerogels vs base-catalyzed aerogels (∼26 vs ∼15 nm, respectively). Additionally, in 900 °C annealed acid- and base-catalyzed xerogels, the silica matrix crystallized as crystobalite and quartz, respectively. EPR data suggest that the Cu2+ environment goes through a series of structural changes upon annealing. These changes are significantly different in acid- vs base-catalyzed systems because of differences in the internal structures and pore distributions of the materials. In both cases, a broad isotropic component, attributed to CuO, is observed upon heating. By 900 °C, the hyperfine peaks originally attributed to dispersed Cu2+ are absent in base-catalyzed systems, but they are still present as a small fraction in acid-catalyzed systems, suggesting incomplete transformation in the latter case.
The Effects of Tantalum for Columbium Substitutions in Alloy 713C (1984)

IN 713C with four levels of Ta and Cb were examined in the as-cast and the alloy chemistry while retaining the improvements in mechanical properties is recommended.
Non-contrast-enhanced MR angiography using 3D ECG-synchronized half-Fourier fast spin echo (2000)

A non-contrast-enhanced three-dimensional (3D) magnetic resonance angiography (MRA) technique, which acquires images in a reasonably short scanning time and requires no contrast agent, is developed. An electrocardiographically (ECG) synchronized 3D half-Fourier fast spin-echo (FSE) technique with an appropriate ECG delay time for every slice encoding in 3D terms was used to examine the thoracic and iliac regions in 16 healthy volunteers at both 0.5 and 1.5 T. Prior to each 3D fresh blood imaging (FBI) experiment, an ECG preparation (ECG-prep) scan was acquired, and an appropriate ECG triggering time was selected for 3D FBI acquisition to optimize visualization of the vessel of interest. In the thoracic and abdominal regions, good-quality 3D MRA images were obtained. Furthermore, the weighted subtraction of two images in different phases provides contrast enhancement between arteries and veins.
From cellulose to a potential substitute for bisphenol A: The design, application, and mechanistic understanding of a hyperbranched catalytic approach (2013)

The mechanism of the acid-catalyzed condensation between levulinic acid and phenol to form diphenolic acid (DPA) was investigated using a combination of sulfonated hyperbranched poly(arylene oxindole)s and thiols. Taft-type steric and electronic parameters were applied to study the correlation.
Automation in the Prefab and Modular Construction Industry (2009)

The construction industry at-large is dominated by numerous small and specialized sub-contractors who typically are not technologically advanced enough to embrace automation. The sector that represents factory built housing (the modular, prefab, panelized, precast, etc.) is an exception. Since the products are built in factories, the principles of mass production and mass customization that are the norm in manufacturing, apply. It will also make it easy to adapt to automation, integration and optimization. In this scenario, the constructability aspects can be verified prior to being built, and an optimum construction plan can be derived. Newer materials can be applied, tight tolerances achieved, while the built products are not affected by outside climatic conditions, as is the case for site built housing. With a view to gauge the needs of automation within the prefab sector, we reviewed several automation technologies relevant to construction, and also have been consulting with the prefab industry to understand their state of practice. This paper summarizes the findings of this study, provides an overview of the type of automation that is prevalent in the industry, and outlines a technology outlook with various elements comprising the aspects of prefab automation. It will help the prefab industry personnel arrive at a broad view of the essence of construction automation, while the research community gets a sense of industry 'pull' in embracing automation.
A modeling approach for Σ-Δ fractional-N frequency synthesizers allowing straightforward noise analysis (2002)

A general model of phase-locked loops (PLLs) is derived which incorporates the influence of divide value variations. The proposed model allows straightforward noise and dynamic analyses of /spl Sigma/-/spl Delta/ fractional-N frequency synthesizers and other PLL applications in which the divide value is varied in time. Based on the derived model, a general parameterization is presented that further simplifies noise calculations. The framework is used to analyze the noise performance of a custom /spl Sigma/-/spl Delta/ synthesizer implemented in a 0.6 /spl mu/m CMOS process, and accurately predicts the measured phase noise to within 3 dB over the entire frequency offset range spanning 25 kHz to 10 MHz.
Gene transcription is coordinated with, but not dependent on, cell divisions during C. elegans embryonic fate specification (2013)

Cell differentiation and proliferation are coordinated during animal development, but the link between them remains uncharacterized. To examine this relationship, we combined single-molecule RNA imaging with time-lapse microscopy to generate high-resolution measurements of transcriptional dynamics in Caenorhabditis elegans embryogenesis. We found that globally slowing the overall development rate of the embryo by altering temperature or by mutation resulted in cell proliferation and transcription slowing, but maintaining, their relative timings, suggesting that cell division may directly control transcription. However, using mutants with specific defects in cell cycle pathways that lead to abnormal lineages, we found that the order between cell divisions and expression onset can switch, showing that expression of developmental regulators is not strictly dependent on cell division. Delaying cell divisions resulted in only slight changes in absolute expression time, suggesting that expression and proliferation are independently entrained to a separate clock-like process. These changes in relative timing can change the number of cells expressing a gene at a given time, suggesting that timing may help determine which cells adopt particular transcriptional patterns. Our results place limits on the types of mechanisms that are used during normal development to ensure that division timing and fate specification occur at appropriate times.