gebhart/patrepeval huggingface dataset:
A projection method for the elimination of contradicting control forces in redundantly actuated PKM (2011)

While redundantly actuated PKM (RA-PKM) possess desirable kinematic and dynamic properties, their control is impeded by the occurrence of antagonistic control forces. Such forces are observed in non-linear model-based as well as in decentralized control schemes. In this paper it is outlined that such antagonistic forces are inherent to the decentralized control of RA-PKM, and also that calibration errors and finite encoder resolutions cause antagonistic control forces and excited vibrations, hence energy loss and instabilities. The effect of measurement errors and the stability of individual PD and computed torque control is analyzed. They are shown to yield asymptotically stable setpoint control. A central result of this paper is a projection method for the elimination of contradicting control commands. This method is valid independently of the actual control scheme. Experimental results are presented for a 2RRR/RR implementation. The results confirm that the proposed scheme reduces antagonistic control forces up to measurement errors and model uncertainties.
Optimization of Neural Network Architecture using Lions Optimization Algorithm (2020)

For several years, humans have observed nature to find patterns and similarities between their problems and natural occurrences. Due to this, there has been a surge of research and algorithms regarding our environment. It is usually a debilitating assignment to structure and manufacture an ANN for a selected issue such as nature. There is a pair of thorough venture rules that are accessible to characterize the ANN and, in any case, numerous parameters to switch. The productive techniques are an option in contrast to counterfeit neural systems planning; however, the computational cost required for specific applications is restrictive. Accordingly, the critical point here is to contemplate progressed developmental calculation strategies, which likewise advance accomplishing ANN structures that commit to the task efficiently, explicit to each issue using Lion's Optimization Algorithm (LOA). Pima Indians Diabetes Database used as a model for the optimization of ANN. The results show that subsequent generations of modeled lions provide better accuracy and efficiency to tend towards the highly optimized solution.
Improvement of inertial sensor based indoor navigation by video content analysis (2011)

Foot-mounted inertial systems for indoor positioning and pedestrian guidance are an elegant and cheap solution to track first responders within buildings and underground structures. They can run completely autonomous, i.e. they do not require preinstalled infrastructure installations. But there are some difficult problems to solve: Starting from a known position the positioning error increases with the travelled distance, if only a double integration of the accelerations is performed. Therefore it is necessary to cut down the integration intervals and to reposition the system from time to time vis-à-vis a known landmark. Several algorithms have been developed at TU Graz to reduce these errors. The precise recognition of the motion patterns allows for performing zero velocity updates (ZUPT) to achieve a high accuracy in distance. Further improvements are gained by the fusion of additional sensors like barometer or GPS. Different map matching algorithms are used to perform periodic repositioning. Since ground floors often are not available, HSLU has developed a video content analysis based repositioning method that increases the accuracy of the heading of the IMU system considerably.
Quantitative Ranking of Ligand Binding Kinetics with a Multiscale Milestoning Simulation Approach (2018)

Efficient prediction and ranking of small molecule binders by their kinetic ( k<sub>on</sub> and k<sub>off</sub>) and thermodynamic ( Δ G) properties can be a valuable metric for drug lead optimization, as these quantities are often indicators of in vivo efficacy. We have previously described a hybrid molecular dynamics, Brownian dynamics, and milestoning model, Simulation Enabled Estimation of Kinetic Rates (SEEKR), that can predict k<sub>on</sub>'s, k<sub>off</sub>'s, and Δ G's. Here we demonstrate the effectiveness of this approach for ranking a series of seven small molecule compounds for the model system, β-cyclodextrin, based on predicted k<sub>on</sub>'s and k<sub>off</sub>'s. We compare our results using SEEKR to experimentally determined rates as well as rates calculated using long time scale molecular dynamics simulations and show that SEEKR can effectively rank the compounds by k<sub>off</sub> and Δ G with reduced computational cost. We also provide a discussion of convergence properties and sensitivities of calculations with SEEKR to establish "best practices" for its future use.
Altered expression of fibroblast activation protein-α (FAP) in colorectal adenoma-carcinoma sequence and in lymph node and liver metastases (2020)

Colorectal cancer (CRC) is a major health problem in elderly people because of its high incidence and high mortality rate. Despite early screening programs, more than half of CRC patients are diagnosed at advanced stages. Fibroblast activation protein-α (FAP) expression in cancer-associated fibroblasts (CAFs) has been associated with a higher risk of metastases and poor survival. Here, we have analyzed the immunohistochemical expression of FAP in 41 adenoma-carcinoma sequences. In addition, FAP expression was analyzed individually and in combination with β-catenin (BCAT), CD44 and Cyclin-D1 expression in primary tumors and in their corresponding lymph node and liver metastases (n=294). Finally, soluble FAP (sFAP) levels in plasma from CRC patients (n=127) were also analyzed by ELISA. FAP was expressed only in CRC tissue and its expression level was found to be higher in tumors exhibiting deeper local invasion and poorer cancer cell differentiation. FAP and concomitant nuclear BCAT expression in cancer cells at the infiltrating front of primary tumors and in lymph node metastases was independently associated with 5- and 10-year cancer specific and disease-free survival. Moreover, lower sFAP levels correlated with poorer survival. These findings support the potential importance of FAP as a biomarker of CRC development and progression.
Cast-Brace Treatment for Fractures of the Distal Part of the Femur (1970)

1. A total-contact, lower-extremity plaster device incorporating brace-joints at the knee has been described for the early ambulatory care of healing fractures in the distal part of the femur. 2. Prospective study of consecutive cases has demonstrated no non-unions or refractures in 150 patients treated with traction followed by early mobilization in a cast-brace and a mean healing time of 14.5 weeks. In a similar but smaller group of fractures treated in the traditional manner by preliminary traction and then immobilized in a spica cast, there were three non-unions, and three refractures occurred after longer periods of immobilization. 3. The factor considered most important for rapid and efficient fracture healing is an environment of function for the healing fracture. Ambulatory function is possible with an unfixed healing fracture of the distal part of the femur when appropriate total-contact support to the limb is provided.
T Cell and Dendritic Cell Abnormalities Synergize to Expand Pro-Inflammatory T Cell Subsets Leading to Fatal Autoimmunity in B6.NZBc1 Lupus-Prone Mice (2013)

We have previously shown that B6 congenic mice with a New Zealand Black chromosome 1 (c1) 96-100 cM interval produce anti-nuclear Abs and that at least two additional genetic loci are required to convert this subclinical disease to fatal glomerulonephritis in mice with a c1 70-100 cM interval (c1(70-100)). Here we show that the number of T follicular helper and IL-21-, IFN-γ-, and IL-17-secreting CD4(+) T cells parallels disease severity and the number of susceptibility loci in these mice. Immunization of pre-autoimmune mice with OVA recapitulated these differences. Differentiation of naïve T cells in-vitro under polarizing conditions and in-vivo following adoptive transfer of OVA-specific TCR transgenic cells into c1(70-100) or B6 recipient mice, revealed T cell functional defects leading to increased differentiation of IFN-γ- and IL-17-producing cells in the 96-100 cM and 88-96 cM intervals, respectively. However, in-vivo enhanced differentiation of pro-inflammatory T cell subsets was predominantly restricted to c1(70-100) recipient mice, which demonstrated altered dendritic cell function, with increased production of IL-6 and IL-12. The data provide support for the role of pro-inflammatory T cells in the conversion of subclinical disease to fatal autoimmunity and highlight the importance of synergistic interactions between individual susceptibility loci in this process.
Clinical implications ofCYP3Apolymorphisms (2006)

Due to their enormous substrate spectrum CYP3A4, -3A5 and -3A7 constitute the most important drug-metabolising enzyme subfamily in humans. CYP3As are expressed predominantly, but not exclusively, in the liver and intestine, where they participate in the metabolism of 45 - 60% of currently used drugs and many other compounds such as steroids and carcinogens. CYP3A expression and activity vary interindividually due to a combination of genetic and nongenetic factors such as hormone and health status, and the impact of environmental stimuli. Over the past several years, genetic determinants have been identified for much of the variable expression of CYP3A5 and -3A7, but not for CYP3A4. Using these markers, an effect of CYP3A5 expression status has been demonstrated beyond doubt for therapies with the immunosuppressive drug tacrolimus. Further associations are likely to emerge for drugs metabolised predominantly by CYP3A5 or -3A7, especially for individuals or tissues with concomitant low expression of CYP3A4. However, as exemplified by the controversial association between CYP3A4*1B and prostate cancer, the detection of clinical effects of CYP3A gene variants will be difficult. The most important underlying problems are the continuing absence of activity markers specific for CYP3A4 and the strong contribution of nongenetic factors to CYP3A variability.
Metabolism of O6-benzylguanine, an inactivator of O6-alkylguanine-DNA alkyltransferase. (1994)

O6-Benzylguanine effectively inactivates the DNA repair protein, O6-alkylguanine-DNA alkyltransferase, leading to an increase in the therapeutic index of 1,3-bis(2-chloroethyl)-1-nitrosourea in nude mouse xenograft studies. To investigate the fate of this inactivator in mammalian systems, we examined its biodistribution and metabolism following i.p. administration of 8-[3H]-O6-benzylguanine to male Sprague-Dawley rats and BALB/c mice. Following administration to rats, there were significantly higher levels of radioactivity in liver than in lung, spleen, kidney, small intestine, and esophagus for up to 24 h. Major urinary metabolites were identified as O6-benzyl-7,8-dihydro-8-oxoguanine, N2-acetyl-O6-benzylguanine, and N2-acetyl-O6-benzyl-7,8-dihydro-8-oxoguanine. Debenzylated metabolites included guanine, 7,8-dihydro-8-oxoguanine, and N2-acetylguanine. In contrast to rat metabolism, acetylated derivatives were not found in mouse urine. However, O6-benzyl-7,8-dihydro-8-oxoguanine was a major metabolite in the mouse. O6-Benzyl-7,8-dihydro-8-oxoguanine was a very effective O6-alkylguanine-DNA alkyltransferase inactivator and exhibited a 50% effective dose in HT29 cell extracts of 0.3 microM compared to 0.2 microM for O6-benzylguanine. The O6-alkylguanine-DNA alkyltransferase depleting activity of N2-acetyl-O6-benzylguanine and N2-acetyl-O6-benzyl-7,8-dihydro-8-oxoguanine were, respectively, 120- and 325-fold lower than O6-benzylguanine in HT29 cell-free extracts.
Quantitative Studies of Muscleblind Proteins and Their Interaction With TCF4 RNA Foci Support Involvement in the Mechanism of Fuchs' Dystrophy (2019)

The low levels of MBNL1/2 in corneal tissue, in combination with the small fraction of protein in the nucleus, may make corneal endothelial cells especially susceptible to sequestration of MBNL1/2 by CUG repeat RNA. These observations may explain how a limited number of RNA molecules can cause widespread alteration of splicing and late-onset degenerative FECD.
A new approach to separate seismic time-lapse time shifts in the reservoir and overburden (2017)

For a robust way of estimating time shifts near horizontal boreholes, we have developed a method for separating the reflection responses above and below a horizontal borehole. Together with the surface reflection data, the method uses the direct arrivals from borehole data in the Marchenko method. The first step is to retrieve the focusing functions and the up-down wavefields at the borehole level using an iterative Marchenko scheme. The second step is to solve two linear equations using a least-squares minimizing method for the two desired reflection responses. Then, the time shifts that are directly linked to the changes on either side of the borehole are calculated using a standard crosscorrelation technique. The method is applied with good results to synthetic 2D pressure data from the North Sea. One example uses purely artificial velocity changes (negative above the borehole and positive below), and the other example uses more realistic changes based on well logs. In the 2D case with an adequate survey coverage at the surface, the method is completely data driven. In the 3D case in which there is a limited number of horizontal wells, a kinematic correct velocity model is needed, but only for the volume between the surface and the borehole. Possible error factors related to the Marchenko scheme, such as an inaccurate source wavelet, imperfect surface multiples removal, and medium with loss are not included in this study.
[Biological evaluation of artificial skin substitute]. (2006)

Multiple kinds of Artificial Skin Substitute are now available. However, except for the Homo Skin Graft there is no Artificial Skin Substitute that can be used as permanent Artificial Skin Substitute. During the past 20 years, more and more scholars around the world have expressed increased interests in the research and development of Artificial Skin Graft that can be utilized as satisfying permanent Artificial Skin Substitute. We conducted our research on the biological evaluation of medical devices of Collagen-Chitosan(C-C) Artificial Skin Substitute according to the National Standard (GB/T16886. 1-1997). The following experiments were conducted: (1)Cytotoxicity, (2)Systemic toxicity(acute toxicity), (3)Haemocompatibility, (4)Sensitization, (5)Intracutaneous reactivity, (6)Pyrogen test, (7)Genotoxicity. The experiment results demonstrate that all biological functional indexes of the Artificial Skin Graft meet the National Standards. Therefore, we conclude that C-C Artificial Skin Graft is characteristic of good biological compatibility. It is non-irritant and has no systemic and cellular toxicity, no genotoxicity, no pyrogen, and no allergen.
COMPARTMENTALIZED EVOLUTION OF PROTEASES FOR MASS SPECTROMETRY-BASED PROTEOMICS (2011)

Proteases are an important class of enzymes ripe for evolution of new function, both as potential therapeutics and as sample preparation tools. Mass spectrometric mapping and discovery of protein posttranslational modifications, a revolutionary new technology in proteomics, begins with tryptic digestion. Regions of protein sequence deficient in tryptic cleavage sites cannot be ionized and mass analyzed, and there are essentially no other proteolytic tools if trypsin digestion does not yield full protein sequence coverage. Compartmentalized selection of proteases with orthogonal specificity can be accomplished with a microfluidic-based platform, addressing a critical need in mass spectrometry proteomics.
ΔFosB: a molecular switch underlying long-term neural plasticity (2000)

Numerous chronic perturbations have been shown to induce highly stable isoforms of the transcription factor deltaFosB in the brain in a region-specific manner. This review examines the functional consequences of the induction of deltaFosB in particular neuronal populations as well as its possible role in behavioral abnormalities such as drug addiction and movement disorders.
Antibacterial activity of traditional therapeutic coastal medicinal plants against some pathogens. (2005)

Antimicrobial activity of 10 traditional coastal medicinal plant species from South west coast of India were tested against 12 human bacterial pathogens and two cattle pathogens. Among the plant species tested, a butanolic extract of Bacopa monnieri showed maximum inhibitory activity against the human pathogen Escherichia coli, whereas the butanolic extract of Aristolochia indica. L showed maximum inhibitory activity against the cattle pathogen Listeria monocytogen. The mean zone of inhibition indicates that the growth of Salmonella enteritidis and Pseudomonas aeruginosa were highly inhibited by the coastal medicinal plant extract than the other bacterial species and also the antibacterial activity was found higher in the butanolic extract than water extract.
Particle swarm with extended memory for multiobjective optimization (2004)

This paper presents a modified dynamic neighborhood particle swarm optimization (DNPSO) algorithm for multiobjective optimization problems. PSO is modified by using a dynamic neighborhood strategy, new particle memory updating, and one-dimension optimization to deal with multiple objectives. An extended memory is introduced to store global Pareto optimal solutions to reduce computation time. Several benchmark cases were tested and the results show that the modified DNPSO is much more efficient than the original DNPSO and other multiobjective optimization techniques.
Molecular Dynamics Simulations of Nanoimprinting Lithography (2009)

We have performed coarse-grained molecular dynamics simulations of molding and replication of nanometer-size objects. Nanoimprinting of hemispherical particles was modeled as a three-step process: (1) a mold was created by pressing a hard hemispherical particle (master template) into a polymeric film; (2) a polymeric film was cross-linked fixing a negative image of a master mold into a polymeric film; (3) a polymeric mold was pressed into a monomeric liquid replicating an original master. The quality of the replication process was analyzed by comparing the shape of the replica with the shape of the master. It is shown that deformation of a polymeric stamp during the replication process (Step 3) is a result of optimization of the surface energy of the mold-liquid interface and the elastic energy of the polymeric mold. The relative deformation, epsilon, of the replica is a function of the universal parameter gamma/(GR(0)), where gamma is the surface energy of the polymer-liquid interface, G is the shear modulus of the polymer network, and R(0) is the radius of the master. In the case of small deformations, this function reduces to epsilon proportional to gamma/(GR(0)).
Fragment-to-Lead Medicinal Chemistry Publications in 2015 (2016)

Fragment-based drug discovery (FBDD) is now well-established as a technology for generating new chemical leads and drugs. This Miniperspective provides a tabulated overview of the fragment-to-lead literature published in the year 2015, together with a commentary on trends observed across the FBDD field during this time. It is hoped that this tabulated summary will provide a useful point of reference for both FBDD practitioners and the wider medicinal chemistry community.
Effect of solvent quality on polyelectrolyte adsorption at an oppositely charged surface (2001)

The effects of the solvent quality on the adsorption of weakly charged polyelectrolytes at an oppositely charged surface are investigated using the self-consistent mean field theory. The analytical solutions of the self-consistent field equations are obtained in the case of θ, good and poor solvents for the polymer backbone. Using these analytical solutions the thickness of the adsorbed layer is calculated as a function of the surface charge density, salt concentration, and solvent quality. It is shown that for polyelectrolyte adsorption from θ and good solvents the surface charge is always overcompensated by adsorbed chains. For low ionic strengths the surface overcharging is inversely proportional to the Debye screening length. However, in the case of adsorption from a poor solvent the adsorbed polyelectrolytes undercompensate the surface charge.
A Language-independent and Compositional Model for Personality Trait Recognition from Short Texts (2016)

Many methods have been used to recognize author personality traits from text, typically combining linguistic feature engineering with shallow learning models, e.g. linear regression or Support Vector Machines. This work uses deep-learning-based models and atomic features of text, the characters, to build hierarchical, vectorial word and sentence representations for trait inference. This method, applied to a corpus of tweets, shows state-of-the-art performance across five traits and three languages (English, Spanish and Italian) compared with prior work in author profiling. The results, supported by preliminary visualisation work, are encouraging for the ability to detect complex human traits.
Sesamin Supplementation Increases White Muscle Docosahexaenoic Acid (DHA) Levels in Rainbow Trout (Oncorhynchus mykiss) Fed High Alpha‐Linolenic Acid (ALA) Containing Vegetable Oil: Metabolic Actions (2008)

The effects of including an equi-mixture of sesamin and episesamin in fish diets based on vegetable oils of different fatty acid composition were examined. Sesamin/episesamin (hereafter named sesamin) was included at 0.58 g/100 g diet. The oil used in the feed was either a mixture of linseed and sunflower oils (6:4, by vol) or 100% linseed oil. Addition of sesamin increased the percentages of docosahexaenoic acid (DHA) in white muscle phospholipid and triacylglycerol fraction by up to 37% but the fatty acids in red muscle and liver were not affected. The expression of the peroxisome proliferator-activated receptor PPARalpha was significantly down regulated in the liver of the fish fed sesamin and mixed oil diet (P < 0.05). Sesamin and episesamin were detected in liver and muscle tissues of the fish that had been fed sesamin. Fish fed sesamin had elevated levels of total cytochrome P450 (CYP) enzymes and EROD activity in the liver, indicating an induction of CYP1A in this tissue. Our conclusion was that supplementation of fish feed with sesamin increased the proportions of DHA in the white muscle.
"Shimmozzel" (1900)

Journal Article "Shimmozzel" Get access James Platt James Platt 1Jun. Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s9-VI, Issue 150, 10 November 1900, Page 371, https://doi.org/10.1093/nq/s9-VI.150.371a Published: 10 November 1900