gebhart/patrepeval huggingface dataset:
Re-epithelialization rate and protein expression in the suction-induced wound model: comparison between intact blisters, open wounds and calcipotriol-pretreated open wounds (2000)

We have investigated re-epithelialization following induction of suction blisters in humans in intact blisters, open wounds, i.e. blister roofs removed immediately after blister induction, and calcipotriol-pretreated open wounds. Intact blisters simulate blister healing in bullous disease, while open wounds simulate re-epithelialization during wound healing. Re-epithelialization was clearly faster in open wounds than in intact blisters, and was not affected by calcipotriol pretreatment. Bullous pemphigoid antigen 2 (BP180), bullous pemphigoid antigen 1 (BP230), plectin/hemidesmosomal 1 protein (HD1), laminin 5, laminin alpha5, laminin beta1, type VII collagen, tenascin-C, beta4, alphavbeta5, alpha5 and alpha9 integrins were studied in intact blisters and open wounds by immunohistochemistry. Hemidesmosomal plaque proteins BP230 and plectin/HD1, which connect the keratin cytoskeleton to the hemidesmosome, appeared earlier at the leading edge in intact blisters than in open wounds. Band-like immunostaining in the basement membrane for laminin 5, alpha5 and beta1 chains was continuous in blister bases, but partially discontinuous in open wound bases. The other antigens studied showed similar expression in intact blisters and open wounds. BP180, BP230, plectin/HD1, beta4 integrin, laminin 5 and tenascin-C expression were further studied in calcipotriol-pretreated open wounds. Calcipotriol did not affect the expression of these antigens. The immunohistochemical results suggest that the keratin cytoskeleton is linked to the basal plasma membrane of migrating basal cells via BP230 and plectin/HD1 earlier in the more slowly re-epithelializing blisters than in open wounds. An intact laminin sheath may inhibit keratinocyte migration in intact blisters.
Candidate Core Designs for the Transformational Challenge Reactor (2021)

Early cycle activities under the Transformational Challenge Reactor (TCR) program focused on analyzing and maturing four reactor core design concepts: two fast-spectrum systems and two thermal-spectrum systems. A rapid, iterative approach has been implemented through which designs can be modified and analyzed and subcomponents can be manufactured in parallel over time frames of weeks rather than months or years. To meet key program initiatives (e.g., timeline, material use), several constraints—including fissile material availability (less than 250 kg of HALEU), component availabilities, materials compatibility, and additive manufacturing capabilities—were factored into the design effort, yielding small (less than one cubic meter in volume) cores with near-term viability. The fast-spectrum designs did not meet the fissile material constraint, so the thermal-spectrum systems became the primary design focus. Since significant progress has been made on advanced moderator materials (YHx) under the TCR program, gas-cooled thermal-spectrum systems using less than 250 kg of HALEU that occupy less than 1 m3 are now feasible. The designs for two of these systems have been evolved and matured. In both thermal-spectrum design concepts, bidirectional coolant flow is used. Coolant flows down through YHx moderator elements and is reversed in a bottom manifold and core support structure, and then flows up though or around the fuel elements. The main difference between the two thermal-spectrum design concepts is the fuel elements—one uses traditional UO2 ceramic fuel, and the other uses UN-bearing TRISO fuel particles embedded inside a SiC matrix. Core neutronics and thermal performance for these systems are assessed and summarized herein.
Five-group cytogenetic risk classification, monosomal karyotype, and outcome after hematopoietic cell transplantation for MDS or acute leukemia evolving from MDS (2012)

Clonal cytogenetic abnormalities are a major risk factor for relapse after hematopoietic cell transplantation (HCT) for myelodysplastic syndrome (MDS). We determined the impact of the recently established 5-group cytogenetic classification of MDS on outcome after HCT. Results were compared with the impact of the International Prognostic Scoring System (IPSS) 3 cytogenetic risk groups, and the additional effect of a monosomal karyotype was assessed. The study included data on 1007 patients, 1-75 years old (median 45 years), transplanted from related (n = 547) or unrelated (n = 460) donors. Various conditioning regimens were used, and marrow, peripheral blood, or cord blood served as stem cell source. Both IPSS and 5-group cytogenetic risk classifications were significantly associated with post-HCT relapse and mortality, but the 5-group classification discriminated more clearly among the lowest- and highest-risk patients. A monosomal karyotype tended to further increase the rates of relapse and mortality, even after considering the IPSS or 5-group classifications. In addition, the pathologic disease category correlated with both relapse and mortality. Mortality was also impacted by patient age, donor type, conditioning regimen, platelet count, and etiology of MDS. Although mortality declined significantly in recent years, novel strategies are needed to overcome the barrier of high-risk cytogenetics.
Microdiffraction analysis of precipitate crystallography and morphology in Al alloys (1990)

Electron microdiffraction has been used to determine the crystallography of precipitation in Al-Cu-Mg-Ag and Al-Ge alloys for individual precipitates with dimensions down to 10 nm. The crystallography has been related to the morphology of the precipitates using an analysis based on the intersection point symmetry. This analysis requires that the precipitate form be consistent with the intersection point group, defined as those point symmetry elements common to precipitate and matrix crystals when the precipitate crystal is in its observed orientation relationship with the matrix. In Al-Cu-Mg-Ag alloys with high Cu:Mg ratios and containing trace amounts of silver, a phase designated Ω readily precipitates as thin, hexagonal-shaped plates on matrix {111} α planes. Examples of these precipitates are shown in Fig. 1. The structure of this phase has been the subject of some controversy. An SAED pattern, Fig. 2, recorded from matrix and precipitates parallel to a &lt;11l&gt; α axis is suggestive of hexagonal symmetry and a hexagonal lattice has been proposed on the basis of such patterns.
Reduction of the Positive Organic Artifact on Quartz Filters (1990)

Quartz fiber filters are routinely used to collect particulate matter for organic analysis. Such collections may be subject to filtration artifacts: enhancement due to the adsorption of gas-phase organic species or diminishment caused by the volatilization of organic particulate matter. The magnitudes of these competing processes are usually difficult to evaluate separately, although significant amounts of organic carbon on second quartz fiber filters (back filters) downstream of the primary sampling filter indicate that these sampling artifacts are present. In an experiment to reduce the enhancement when sampling organic particulate matter, a diffusive denuder consisting of separated layers of quartz fiber filter was used under the hypothesis that it would selectively remove only those gaseous organic species that normally are retained by the filter medium. This denuder reduced the organic carbon on the back filter by more than a factor of four, to levels comparable to those of the filter blank; the organic carbon on the front filter was reduced by the same absolute amount. The conclusion is that a quartz fiber filter denuder nearly eliminates the enhancement artifact.
Simplified SLAM using reflection intensity of laser range sensor with retro-reflective marker (2012)

The mobile robot that support of human requires self-localization and to make environment map. Therefore, this study is using SLAM that is required landmark (LM). Hence, the survey for material of LM did experiment by some material. Material of LM was performed using a reflector from survey result. And, SLAM was constructed using this LM. Also, algorithm of SLAM confirm by using the simulator. Finally, Localization and environmental mapping relating experiment of accuracy was performed.
Variable-Length Bit Mapping and Error-Correcting Codes for Higher-Order Alphabet PUFs. (2017)

Device-specific physical characteristics provide the foundation for Physical Unclonable Functions (PUFs), a hardware primitive for secure storage of cryptographic keys. So far, they have been implemented by either directly evaluating a binary output or by mapping outputs from a higher-order alphabet to a fixed-length bit sequence. However, the latter causes a significant bias in the derived key when combined with an equidistant quantization.
Observation of converted and unconverted light pulses preserving phase of an input light in difference frequency generation at a single-photon level (2013)

We experimentally demonstrate that both a converted and an unconverted light pulses after wavelength conversion with various conversion efficiencies preserve phase information of an input light at a single-photon level. In our experiment, we converted temporally-separated two coherent light pulses with average photon numbers of $\sim$ 0.1 at 780 nm to light pulses at 1522 nm by using difference-frequency generation in a periodically-poled lithium niobate waveguide. We observed a single-photon interference between temporally-separated two modes for both the converted and the unconverted light pulses at various values of the conversion efficiency. We observed interference visibilities greater than 0.88 without suppressing the background noises for any value of the conversion efficiency the wavelength converter achieves. At a conversion efficiency of $\sim$ 0.5, the observed visibilities are 0.98 for the unconverted light and 0.99 for the converted light.
[Aarskog syndrome in association with mental and psychological retardation, grand mal epilepsy and tardive dyskinesia and apparent radicular paralysis of the fibular nerve in torsion scoliosis]. (1993)

The case of an about 22-year-old patient with AARSKOG-syndrome is reported whose scoliosis caused a radicular impairment with resulting severe paresis of the right fibular nerve. The syndrome was also associated with moderate mental retardation, epilepsy, premature craniosynostosis and tardive dyskinesias after neuroleptic therapy because of disorders of behaviour. The risks of idiopathic scoliosis in patients with dysmorphia-retardation syndromes should be taken into consideration and such children should be supervised by an orthopaedist.
Cyclic Changes in Enzyme Activity in Synchronized Mammalian Cell Cultures (1968)

Activity of the enzymes glucose-6-phosphate dehydrogenase and lactate dehydrogenase increases intermittently in synchronized cultures of Chinese hamster cells. During G(1) phase (3 hours after mitosis), midway through S phase (7 hours after mitosis) and again in late S phase (10 hours after mitosis), rapid increases in activity were observed and correlated with a net increase in cell size and total protein. The evidence suggests that this is a general phenomenon which affects a whole population of proteins and may be the expression of an endogenous cellular rhythm.
Reliability Analysis for Automobile Engines: Conditional Inference Trees (2018)

The reliability model with covariates for machinery parts has been extensively studied by the proportional hazards model (PHM) and its variants. However, it is not straightforward to provide business recommendations based on the results of the PHM. We use a novel method, namely the Conditional Inference Tree, to conduct the reliability analysis for the automobile engines data, provided by a UK fleet company. We find that the reliability of automobile engines is significantly related to the vehicle age, early failure, and repair history. Our tree-structured model can be easily interpreted, and tangible business recommendations are provided for the fleet management and maintenance.
Palladium‐catalyzed allylation of α‐hydroxy acids (1992)

Abstract Mandelic and lactic acids are converted to the 1,3‐dioxolan‐4‐ones by treatment with acetone dimethyl acetal. Deprotonation followed by treatment with an allyl acetate and a catalytic amount (1 mol %) of palladium catalyst afforded the allylated dioxolanones, which could be hydrolyzed to the corresponding α‐allyl α‐hydroxy acids. The lithium enolate of the dioxolanone of mandelic acid was also coupled with methallyl, cinnamyl, geranyl and ( E )‐1‐methyl‐2‐butenyl acetates. The zinc enolate of the dioxolanone of lactic acid reacted smoothly with allyl acetate in a catalyzed reaction whereas no detectable reaction was observed when the lithium enolate was used. This appears to be the result of complications arising from the enhanced basicity of the lithium compared to zinc enolate. Various attempts were made to achieve enantioselectivity using chiral ligands on the palladium catalyst. The zinc enolates were found to provide better results although the enantioselectivity was only modest, about 30% enantiomeric excess being the best result obtained. Chiraphos proved to be the best optically active ligand of a variety tested.
Transfection of Adipocytes by Gene Gun-Mediated Transfer (1999)

Studies of the gene expression, metabolism and intracellular signaling of adipocytes have been hindered by the difficulty of transfecting cultured adipocytes using standard methods. Here, we demonstrate the utility of gene gun-mediated genetic transfer for transfection of differentiated 3T3-L1 adipocytes. Transfection of adipocytes with the Helios Gene Gun yielded a transfection efficiency that was consistently 5%-10% of total cells. We have used this technique to overexpress the transcription factor CCAAT/Enhancer Binding Protein alpha (C/EBP alpha) and transactivate an obese gene promoter-luciferase construct. This method has broad utility for transfection of other cell types that are resistant to transfection.
INTRODUCING THE UBC CHAIR IN DESIGN ENGINEERING - BREAKING OUT OF DISCIPLINARY SILOS (2011)

UBC was recently awarded an NSERC Chair in Design Engineering (CDEN). The focus of this chair is addressing the problem of ‘disciplinary silos’ in engineering education, primarily through enhancing cross-departmental and cross-faculty initiatives. Our principal initiative is a multidisciplinary senior design course which will bring together engineers from different departments in a year-long project sponsored by external clients. We will also establish a new building – the $6.6M Wayne and William White Engineering Design Centre – which will serve as the focal point for faculty-wide design activities.
Ge Oxidation in the Remaining Cores of Si<SUB>1–<I>x</I></SUB>Ge<SUB><I>x</I></SUB> Nanowires After Prolonged Oxidation (2012)

For this investigation of the Ge behavior of condensed Si(1-y)Ge(y) (y > x) cores during the oxidation of Si(1-x)Ge(x) nanowires, Si(1-x)Ge(x) nanowires were grown in a tube furnace by the vapor-liquid-solid method and thermally oxidized. The test results were characterized using several techniques of transmission electron microscopy. The two types of Ge condensation are related to the diameter and Ge content of the nanowires. The consumption of Si atoms in prolonged oxidation caused the condensed SiGe cores to become Ge-only cores; and the continuous oxidation resulted in the oxidation of the Ge cores. The oxidation of Ge atoms was confirmed by scanning transmission electron microscopy.
A high performance 0.1 μm MOSFET with asymmetric channel profile (2002)

This paper describes nonequilibrium transport phenomenon, practical fabrication process, and potential design of an asymmetric 0.1 /spl mu/m n-MOSFET for the first time. The self-consistent Monte Carlo device simulation coupled with a process simulator reveals the carrier velocity overshoot at the source side of the channel. It is found that the 0.1 /spl mu/m MOSFET with asymmetric channel profile realizes high device performance due to the high carrier velocity.
BDCI: behavioral driven conflict identification (2017)

Source Code Management (SCM) systems support software evolution by providing features, such as version control, branching, and conflict detection. Despite the presence of these features, support to parallel software development is often limited. SCM systems can only address a subset of the conflicts that might be introduced by developers when concurrently working on multiple parallel branches. In fact, SCM systems can detect textual conflicts, which are generated by the concurrent modification of the same program locations, but they are unable to detect higher-order conflicts, which are generated by the concurrent modification of different program locations that generate program misbehaviors once merged. Higher-order conflicts are painful to detect and expensive to fix because they might be originated by the interference of apparently unrelated changes.
Randomized routing of virtual connections in essentially nonblocking log N-depth networks (1995)

An optimal N/spl times/N circuit switching network with /spl theta/(N/spl times/N) bandwidth has a lower bound of /spl theta/(N/spl middot/log N) hardware, which includes all crosspoints, bits of memory and logic gates, and a lower bound of /spl theta/(logN) set-up time. To date no known self-routing circuit switching networks with explicit constructions achieve these lower bounds. The authors consider a randomized routing algorithm on a class of circuit switching networks called "extended dilated banyans". It is proven that the blocking probability of an individual connection request is O[log/sub b/ N/spl middot/(k/d)/sup d/], where d is the dilation factor and k is a constant. With a dilation of /spl theta/(log log N) and a loading <1 the blocking probability is shown to approach zero, yielding an "essentially nonblocking" network. The hardware complexity of these networks depends upon the internal node implementation. A space division node yields a network with /spl theta/(N/spl middot/log N/spl middot/log log N) hardware and /spl theta/(log N/spl middot/log log N) set-up time. A time division node, in which the bits from each connection are dynamically concentrated in time using a "time-bit-concentrator" circuit, yields a network with an asymptotically optimal O(N/spl middot/log N) hardware and a slightly suboptimal /spl theta/(log N/spl middot/log log N) set-up time. Both implementations improve upon the best known explicit constructions of self-routing circuit switching networks with /spl theta/(N) bandwidth, and the TDM construction meets Shannon's lower bound on the cost of such networks. It is shown that extended dilated banyans can carry significantly more traffic than the Batcher-banyan switch and its variants.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Traditional Uses, Phytochemistry, and Bioactivities ofCananga odorata(Ylang-Ylang) (2015)

Ylang-ylang (Cananga odorata Hook. F. & Thomson) is one of the plants that are exploited at a large scale for its essential oil which is an important raw material for the fragrance industry. The essential oils extracted via steam distillation from the plant have been used mainly in cosmetic industry but also in food industry. Traditionally, C. odorata is used to treat malaria, stomach ailments, asthma, gout, and rheumatism. The essential oils or ylang-ylang oil is used in aromatherapy and is believed to be effective in treating depression, high blood pressure, and anxiety. Many phytochemical studies have identified the constituents present in the essential oils of C. odorata. A wide range of chemical compounds including monoterpene, sesquiterpenes, and phenylpropanoids have been isolated from this plant. Recent studies have shown a wide variety of bioactivities exhibited by the essential oils and the extracts of C. odorata including antimicrobial, antibiofilm, anti-inflammatory, antivector, insect-repellent, antidiabetic, antifertility and antimelanogenesis activities. Thus, the present review summarizes the information concerning the traditional uses, phytochemistry, and biological activities of C. odorata. This review is aimed at demonstrating that C. odorata not only is an important raw material for perfume industry but also considered as a prospective useful plant to agriculture and medicine.
Performance analysis of reduced-rank STAP (2002)

The space-time radar problem is well suited to the application of techniques that take advantage of the low-rank property of the space-time covariance matrix. In particular, it was shown that when the space-time covariance matrix is estimated from a dataset with limited support, reduced-rank methods outperform full-rank space-time adaptive processing (STAP). We study the application of several reduced-rank methods to the STAP problem and demonstrate their utility by simulations in terms of the output signal-to-noise ratio and detection probability. It is shown that reduced-rank processing has two opposite effects on the performance: increased statistical stability which tends to improve performance, and introduction of a bias which lowers the signal-to-noise ratio. Several reduced-rank methods are analyzed and compared for both cases of known and unknown covariance matrix. While the best performance is obtained using transforms based on the eigendecomposition (data dependent), the loss incurred by the application of fixed transforms (such as the discrete cosine transform) is relatively small. The main advantage of fixed transforms is the availability of efficient computational procedures for their implementation. These findings suggest that reduced-rank methods could facilitate the development of practical, real-time STAP technology.
Chemo-photothermal effects of doxorubicin/silica–carbon hollow spheres on liver cancer (2018)

Chemo-photothermal therapy, which exhibits synergistic effects, is more effective than either of the treatments administered alone because of its superior ability to target and destroy cancer cells. An anti-cancer compound (doxorubicin, DOX) was embedded in silica-carbon hollow spheres (SCHSs) using heat and vacuum to integrate multi-therapeutic effects onto one platform and subsequently improve the anti-cancer efficacy. SCHSs were synthesized <i>via</i> a surface activation method and its highly porous surface enhanced the loading content of the desired drug. SCHSs are an infrared photothermal material that can destroy targeted cells by heating under near-infrared (NIR) laser illumination at 808 nm. NIR laser illumination also enhances DOX release from SCHSs to increase the anti-cancer efficiency of DOX-loaded SCHSs (DOX-SCHSs) in both two-dimensional and three-dimensional multicellular tumor spheroid cultures. SCHSs exhibited high heat-generating ability and pH-responsive drug delivery. In conclusion, this study demonstrated that DOX-SCHSs represent a potential tool for chemo-photothermal therapy due to its photothermal effects. Thus, our findings imply that the high cancer cell killing efficiency of DOX-SCHSs induced by NIR illumination can be used for the treatment of tumors.
Angiostatin gene transfer as an effective treatment strategy in murine collagen‐induced arthritis (2002)

Local production of angiostatin in the knee was able to prevent the onset of CIA not only in the knee injected with genetically engineered cells, but also in the uninjected ipsilateral paw. This suggests that transfer of the angiostatin gene, and potentially also its protein, may provide a new, effective approach to the treatment of rheumatoid arthritis.
Spectral Graph Theory (1996)

Eigenvalues and the Laplacian of a graph Isoperimetric problems Diameters and eigenvalues Paths, flows, and routing Eigenvalues and quasi-randomness Expanders and explicit constructions Eigenvalues of symmetrical graphs Eigenvalues of subgraphs with boundary conditions Harnack inequalities Heat kernels Sobolev inequalities Advanced techniques for random walks on graphs Bibliography Index.