gebhart/patrepeval huggingface dataset:
Role of retinal pigment epithelium in the development of experimental autoimmune uveitis. (1994)

These results indicate that the retinal pigment epithelium may play a role in the initiation and perpetuation of uveitis after sensitization with S antigen. The effect of NaIO3 appears to be localized to the retinal pigment epithelium; it had no effect on immune reactive cells, as evidenced by the development of experimental allergic encephalomyelitis in animals treated with NaIO3.
SIMULATION OF BIOEQUIVALENCE STUDY ON THE BASE OF DISSOLUTION CURVES (2014)

A computer method and software based on the in vitro dissolution of drug preparations has been elaborated for the estimation of bioequivalence using Microsoft Excel 2007, Visual Basic programming language. The method generates a „dissolution surface ‖ from the parameters of time (X-axis), from pH (Y-axis) and from the dissolved amount (A) in % of the drug. This dissolution surface allows the determination of the general dissolution curve of the test and reference preparations. By supposing that the absorption rate constant is known from the literature, the change of the amount of dissolved drug as the function of time can be determined. On the base of this function the maximum amount of the dissolved drug in the gastrointestinal tract and the AUC can be calculated and the test/reference ratio can be determined. In the case of linear pharmacokinetics these ratios are identical to the ratios of parameters that can be calculated in the circulation. By generating parameters between the allowed biological limits the dissolved drug – time curves of „volunteers ‖ in the necessary number are created with the randomly generated „residence times ‖ and their confidence intervals can be determined, i.e. on the base of dissolution curves bioequivalence can be estimated.
Proton diffusion tensor spectroscopy of metabolites in human muscle in vivo (2014)

Diffusivities, directional dependence of diffusion and fractional anisotropies of (1) H MRS-visible muscle metabolites were presented. It was shown that metabolites share diffusion directionality with water and have similar fractional anisotropies, hinting at similar diffusion barriers.
Down Hole Corrosion: Problems & Possible Solutions (1995)

Abstract Over the past several years the industry has encountered many production problems in the Antrim play. Among these are calcium carbonate scale, NORM and C02 removal. One problem, the oorrosion of steel within the production system, has developed due to the chemical nature of the Antrim gas and water. This corrosion has become a major problem for NOMECO and other operators. This paper will discuss the problem, its source and effects and some possible solutions.
Communication optimizations for global multi-threaded instruction scheduling (2008)

The recent shift in the industry towards chip multiprocessor (CMP) designs has brought the need for multi-threaded applications to mainstream computing. As observed in several limit studies, most of the parallelization opportunities require looking for parallelism beyond local regions of code. To exploit these opportunities, especially for sequential applications, researchers have recently proposed global multi-threaded instruction scheduling techniques, including DSWP and GREMIO. These techniques simultaneously schedule instructions from large regions of code, such as arbitrary loop nests or whole procedures, and have been shown to be effective at extracting threads for many applications. A key enabler of these global instruction scheduling techniques is the Multi-Threaded Code Generation (MTCG) algorithm proposed in [16], which generates multi-threaded code for any partition of the instructions into threads. This algorithm inserts communication and synchronization instructions in order to satisfy all inter-thread dependences. In this paper, we present a general compiler framework, COCO, to optimize the communication and synchronization instructions inserted by the MTCG algorithm. This framework, based on thread-aware data-flow analyses and graph min-cut algorithms, appropriately models andoptimizes all kinds of inter-thread dependences, including register, memory, and control dependences. Our experiments, using a fully automatic compiler implementation of these techniques, demonstrate significant reductions (about 30% on average) in the number of dynamic communication instructions in code parallelized with DSWP and GREMIO. This reduction in communication translates to performance gains of up to 40%.
Effect of some polyvalent cations on plaque formation in vivo (1978)

The purpose of the present study was to investigate the effect of polyvalent cations on plaque formation in a test panel of students. Heavy plaque formers were selected and plaque formation was enhanced by frequent sucrose rinses. Mouthrinses were performed twice daily with 20 mmol/l SnF2, SnCl2, AlCl3, ZnCl2 and MgCl2, and 40 mmol/l NaF and NaCl. It was found that SnF2 AND SnCl2 exhibited a marked plaque-inhibiting capacity compared with NaF or NaCl. The aluminum, zinc and magnesium salts also reduced plaque formation, although not to the same degree. Polyvalent cations may prevent plque formattion by interaction with negatively charged plaque components essential in the adsorption mechanism, or by inhibiting some enzyme activity essential in plaque formation.
Electrical and Anatomical Imaging of Arrhythmogenic Substrates for Scar-related Ventricular Tachycardia (2017)

Sustained ventricular tachycardia (VT) often involves a reentry circuit formed by narrow channels of surviving tissue within the scar. Catheter ablation is an effective technique to intercept the circuit by targeting these critical channels. The success of VT ablation relies on our ability to assess the mechanism of the VT circuit and identify the location of the ablation targets. This study aims to analyze the VT substrate using high-resolution anatomical and electrical imaging techniques including contact EGM mapping, contrast-enhanced cardiac magnetic resonance (CMR) imaging, and noninvasive electrocardiographic (ECG) imaging. The results indicate that joint electro-anatomical analysis could reveal critical isthmus of the VT circuit. In addition, ECG-imaging was able to identify sites of a scar and signal fractionation visually consistent with the other two modalities, and the reconstructed VT circuit revealed an exit around the critical site identified by combined CMR-EGM data.
The Nature of the Heterozygous Trp53 Knockout Model for Identifi cation of Mutagenic Carcinogens (2001)

The heterozygous Trp53 null allele C57BL/6 (N5) mouse is susceptible to the rapid development of neoplasia by mutagenic carcinogens relative to control strains. This mouse model of chemical carcinogenesis demonstrates 1) dose-related rapid induction of tumors (26 wks), 2) multiple sites of carcinogen-specific tissue susceptibility, and 3) carcinogen-induced loss of heterozygosity involving the Trp53 wild-type allele or a p53 haploinsufficiency permitting mutation of other critical protooncogenes and/or inactivation of tumor suppressor genes driving tumorigenesis. Demonstration of mutation or loss of heterozygosity involving the Trp53 locus is consistent with a common finding in human cancers and supports extrapolation between rodents and humans. Using diverse experimental protocols, almost all mutagenic rodent carcinogens (including all mutagens that are carcinogenic to humans), but not nonmutagenic rodent carcinogens, induce tumors within 26 weeks of continuous exposure. These characteristics and results indicate that the mouse heterozygous for the Trp53 null allele may be of significant use for the prospective identification of mutagenic carcinogens of potential risk to human health.
A Large-Scale, Energetic Model of Cardiovascular Homeostasis Predicts Dynamics of Arterial Pressure in Humans (2008)

The energetic balance of forces in the cardiovascular system is vital to the stability of blood flow to all physiological systems in mammals. Yet, a large-scale, theoretical model, summarizing the energetic balance of major forces in a single, mathematically closed system has not been described. Although a number of computer simulations have been successfully performed with the use of analog models, the analysis of energetic balance of forces in such models is obscured by a big number of interacting elements. Hence, the goal of our study was to develop a theoretical model that represents large-scale, energetic balance in the cardiovascular system, including the energies of arterial pressure wave, blood flow, and the smooth muscle tone of arterial walls. Because the emphasis of our study was on tracking beat-to-beat changes in the balance of forces, we used a simplified representation of the blood pressure wave as a trapezoidal pressure-pulse with a strong-discontinuity leading front. This allowed significant reduction in the number of required parameters. Our approach has been validated using theoretical analysis, and its accuracy has been confirmed experimentally. The model predicted the dynamics of arterial pressure in human subjects undergoing physiological tests and provided insights into the relationships between arterial pressure and pressure wave velocity.
Anterior Single-Rod Instrumentation of the Thoracic and Lumbar Spine: Saving Levels (2003)

Single-rod anterior instrumentation will often saved one to three distal fusion levels when treating isolated major thoracic, thoracolumbar, or lumbar curves. Fusion levels should include upper to lower Cobb levels. Additionally, anterior single-rod instrumentation because its kyphogenic nature will predictably correct hypokyphosis of the thoracic spine.
Figure 2 from The Immunopeptidome from a Genomic Perspective: Establishing the Noncanonical Landscape of MHC Class I–Associated Peptides (2023)

&lt;p&gt;COD-dipp: A new high-throughput pipeline for a deep interrogation of immunopeptidomic datasets. Samples are first analyzed with an open search strategy to detect the landscape of PTMs. An FLR for the PTMs and FDR of 1% are applied. Simultaneously, the samples are analyzed using a novel &lt;i&gt;de novo&lt;/i&gt; approach to identify noncanonical peptides. The &lt;i&gt;de novo&lt;/i&gt; strategy trains a model per sample using quality-controlled PSMs from the MS-GF+ search engine to learn the direct interpretation of sample-specific mass spectra. The MS-GF+ results are split into three groups: training and testing to tune the hyperparameters and account for overfitting, and a validation group to approximate the accuracy per sample. &lt;i&gt;De novo&lt;/i&gt; predicted peptides with an accuracy of at least 90% are sequentially mapped against the Human proteome (HP) then a 3-frame translation (3FT) database of protein-coding genes (1 mismatch allowed between leucine/isoleucine, i.e., Xle). Predicted &lt;i&gt;de novo&lt;/i&gt; peptides matching any known protein are labeled “canonical”. Peptides mapping to the 3FT database with at least 3 amino acids mismatches from any known protein sequence are labeled “noncanonical”. Finally, a second-round search is performed as a validation approach. Four of the most abundantly identified PTMs and a custom database consisting of ENSEMBL proteins and noncanonical peptides are considered. The resulting canonical and noncanonical peptides are controlled to an FDR of 1% and aligned to the hg38 human genome.&lt;/p&gt;
On Explainability of A Simple Classifier for AR(1) Source (2022)

The heuristic reasoning and experiments based design approach have been the pillars of studies on artificial neural networks. The explainable network performance is required for most applications. We focus on a simple classifier network for the two-class case of AR(1) data sources. We trace the input statistics through the network and quantify changes to explain relationship between accuracy performance, optimized parameters and activation function types employed for the given architecture. We present test accuracy results for various network configurations with different dimension and activation types. AR(1) source model for a two-class case is utilized to generate training and test data sets of the experiments due to its ease of use for analytical study. We quantify the relationships with well known metrics among signal (class) statistics, network architecture, activation function type and accuracy for several correlation coefficient pairs of the two AR(1) sources utilized in this paper. It is observed from the experiments that the analyses of data, input-output relationships of hidden and output layer nodes for the given architecture provide invaluable insights and guidance to judiciously design a neural network and to explain its performance based on characteristics of the building blocks.
Garbage collection in object oriented systems (1991)

article Free Access Share on Garbage collection in object oriented systems Authors: Paul R. Wilson View Profile , Barry Hayes View Profile Authors Info & Claims ACM SIGPLAN OOPS MessengerVolume 3Issue 4Oct. 1, 1992 pp 63–71https://doi.org/10.1145/143776.143792Published:01 September 1991Publication History 8citation393DownloadsMetricsTotal Citations8Total Downloads393Last 12 Months21Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Kinect One-based biomechanical assessment of upper-limb performance compared to clinical scales in post-stroke patients (2015)

This paper presents a Kinect One sensor-based protocol for the evaluation of the motor-performances of the upper limb of neurological patients during rehabilitative sessions. The assessment provides evaluations of kinematic, dynamic, motor and postural control variables. A pilot study was conducted on three post-stroke neurological patients, comparing Kinect-One biomechanical assessment with the outcomes of some of the most common clinical scales for the evaluation of the upper-limb functionality. Preliminary results indicate coherency between the clinical and instrumental evaluation. Moreover, the Kinect-One assessment seems to provide some complementary quantitative information, consistently integrating the clinical assessment.
Absolute configuration of the unique 2,6-dideoxy-4-O-methyl-arabino-hexopyranose of the major phenolic glycolipid antigen from Mycobacterium kansasii (1987)

The antigenicity and the structure of the major phenolic glycolipid from Mycobacterium kansasii have been established. A monoacetylated tetrasaccharide structure was proposed for the oligosaccharide moiety in which the distal sugar, unique in nature, corresponds to 2,6-dideoxy-4-O-methyl-alpha-arabinohexopyranose. Its terminal position in the oligosaccharide part confers to this residue a key role in the antigen-antibody interaction. By improvement of the methanolysis procedure, this new kind of sugar was obtained in higher amounts than by hydrolysis of the glycolipid. Its 1H-NMR spectrum is presented and its optical rotatory power measurement agrees with a D absolute configuration while the deoxyhexoses involved in the glycolipid tetrasaccharide structure present the L absolute configuration.
Regulation of HLA-DR and Costimulatory B7 Molecules in Human Thyroid Carcinoma Cells: Differential Binding of Transcription Factors to the HLA-DRα Promoter (1998)

The consequence of autoantigen presentation by thyroid cells is dependent on the magnitude of expression of both HLA class II antigens (mainly HLA-DR) and costimulatory molecules, such as B7 (CD80 and CD86). Autoimmune thyrocytes are induced to express HLA-DR by interferon-gamma (IFN-gamma). The costimulatory signal leading to autoantibody production or cytotoxic T-cell immune response could be provided by antigen presenting cells (APCs) attracted to the thyroid by the primary autoimmune stimulus. Malignant thyrocytes can express HLA-DR antigens either constitutively, as a result of a nonimmunologic stimulus, or on induction with IFN-gamma after triggering of an immune response. However, their ability to express B7 molecules, which may determine enhanced antitumoral immune response mainly in the absence of intrathyroidal macrophages, has not yet been studied. The regulation of HLA-DR gene expression in APCs, such as B cells, is mediated by a series of short DNA consensus sequences located in the promoter, termed the W, X, and Y boxes, which bind several known transcription factors. We have previously characterized the expression of HLA-DR in four human thyroid carcinoma cell lines and found differences between constitutive and high- or moderate-induced expression of the protein and mRNA. Evaluation of B7 expression on the surface of thyroid cancer cells and understanding the mechanisms of HLA-DR gene expression may help in designing efficient immune response to thyroid tumors. Using the electrophoretic mobility shift assay (EMSA), we have demonstrated differences between the four thyroid cell lines in the binding of transcription factors to each of the three boxes. The binding to the promoter in each of the cell lines resulted in a single band, probably representing a complex of proteins formed via protein-protein interactions. Using flow cytometry we have shown that the B7 molecule was absent in the four thyroid cell lines and could not be induced by IFN-gamma. The absence of surface B7 molecules from the malignant thyroid cells may lead to either suppression of antitumoral cytotoxic T cell response or demand the cooperation of infiltrating APCs to favor immune response. Differences previously found in HLA-DR expression in the four human malignant thyroid cell lines may be explained by the variation in the binding of transcription factors to the boxes in the HLA-DRalpha promoter. The binding patterns of nuclear proteins derived from the four thyroid cell lines or from the B lymphocyte cell line--Raji--to each of the boxes or to the whole promoter exhibit similarities, thus suggesting similar DNA-protein interactions.
EMC analysis of an 18" LCD monitor (2002)

This paper describes a case study covering the evaluation and reduction of the radiated EMI from an 18" liquid crystal display (LCD) monitor. The evaluation was completed in two parts: first potential EMI sources at the printed circuit board (PCB) level were identified, then the EMI antennas driven by these sources were analyzed. Methods for reducing the EMI were described in detail, and where applicable, those modifications were applied. Radiated measurements demonstrate the effectiveness of these recommendations.
Chaos in atmospheric pressure plasma jets (2011)

Summary form only given, as follows. Atmospheric pressure plasma jets have received considerable attention recently for use in many emerging materials processing and biomedical applications <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1, 2</sup> . Such devices offer the unique ability to generate plasma in a region of inert gas which is then transported in to a region of reactive gas thus simultaneously offering both stability and reactivity. Recently, experimental studies have shown that dielectric barrier plasma jets exhibit a wide range of dynamic behavior; this casts doubt over their ability to deliver process repeatability, a critical criterion in many applications <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> . Clearly, there is a real need to understand and characterize this dynamic behavior and determine its impact upon the discharge characteristics. This contribution examines the manifestation of deterministic chaos in a dielectric barrier helium plasma jet. Power spectral density, phase-space representations, stroboscopic sections and Lyapunov exponents are all used to characterize the dynamics of the system and obtain a deep insight into its chaotic behavior.
Disruption of ST5 is associated with mental retardation and multiple congenital anomalies (2009)

Hence, the authors suppose that ST5 plays an important role in central nervous system development probably due to disturbance of DENN-domain-mediated vesicle formation and neurotransmitter trafficking. Thus, these findings implicate ST5 in the aetiology of mental retardation, seizures and multiple congenital anomalies.
Preamplifier Noise Figure Measurement and Radio Frequency Field Optimization in High Field Magnetic Resonance Imaging (2013)

High field magnetic resonance imaging (MRI) is an area of research interest due to the associated improvement in image quality possible. This improvement comes at a cost. Hardware design becomes more complex in order to overcome technical challenges at these higher field strengths. Signal-to-noise ratio is of paramount importance to MR image quality and this comes from carefully designed hardware and pulse sequences. This thesis focuses on the radiofrequency hardware of a high field MRI system. As frequency increases, the difficulties associated with radiofrequency hardware design increase. A noise figure and noise parameter measurement system was developed for measurement of the noise added by measurement electronics in MRI. Noise figure was found to increase for many transistor semiconductors as magnetic field increased. The radiofrequency transmit field was also studied. Radiofrequency hardware was modified to optimize the radiofrequency field to achieve proper contrast in MR images and improve transmit power efficiency.
Exposing datapath elements to reduce microprocessor energy consumption (2001)

Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2001.
A reverse transcription loop-mediated isothermal amplification assay to rapidly diagnose foot-and-mouth disease virus C (2014)

A reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay was developed to rapidly detect foot-and-mouth disease virus serotype C (FMDV C). By testing 10-fold serial dilutions of FMDV C samples, sensitivity of the FMDV C RT-LAMP was found to be 10 times higher than that of conventional reverse transcription- PCR (RT-PCR). No cross-reactivity with A, Asia 1, or O FMDV or swine vesicular disease virus (SVDV) indicated that FMDV C RT-LAMP may be an exciting novel method for detecting FMDV C.
supplemental figure legend from Blocking HSP90 Addiction Inhibits Tumor Cell Proliferation, Metastasis Development, and Synergistically Acts with Zoledronic Acid to Delay Osteosarcoma Progression (2023)

&lt;p&gt;supplemental figure legend&lt;/p&gt;
Protection Against Hardware Trojan Attacks: Towards a Comprehensive Solution (2012)

With the increasing disintegration of the design and manufacturing chain of our microelectronic products, we should not only worry about including unintentional, unwanted hardware features (“bugs”), but also about including intentional malicious hardware features: “Trojan Horses,”which act as spies or terrorists. This article provides an overview of hardware Trojans and countermeasures.