gebhart/patrepeval huggingface dataset:
Novel Pyrazinone Inhibitors of Mast Cell Tryptase: Synthesis and SAR Evaluation. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
A predictive control framework for optimal energy extraction of wind farms (2016)

&lt;p&gt;This paper proposes an adjoint-based model predictive control for optimal energy extraction of wind farms. It employs the axial induction factor of wind turbines to influence their aerodynamic interactions through the wake. The performance index is defined here as the total power production of the wind farm over a finite prediction horizon. A medium-fidelity wind farm model is utilized to predict the inflow propagation in advance. The adjoint method is employed to solve the formulated optimization problem in a cost effective way and the first part of the optimal solution is implemented over the control horizon. This procedure is repeated at the next controller sample time providing the feedback into the optimization. The effectiveness and some key features of the proposed approach are studied for a two turbine test case through simulations.&lt;/p&gt;
Intracellular Calcium Disturbances Induced by Arsenic and Its Methylated Derivatives in Relation to Genomic Damage and Apoptosis Induction (2005)

Arsenic and its methylated derivatives are contaminants of air, water, and food and are known as toxicants and carcinogens. Arsenic compounds are also being used as cancer chemotherapeutic agents. In humans, inorganic arsenic is metabolically methylated to mono-, di-, and trimethylated forms. Recent findings suggest that the methylation reactions represent a toxification rather than a detoxification pathway. In recent years, the correlation between arsenic exposure, cytotoxicity and genotoxicity, mutagenicity, and tumor promotion has been established, as well as the association of arsenic exposure with perturbation of physiologic processes, generation of reactive oxygen species, DNA damage, and apoptosis induction. Trivalent forms of arsenic have been found to induce apoptosis in several cellular systems with involvement of membrane-bound cell death receptors, activation of caspases, release of calcium stores, and changes of the intracellular glutathione level. It is well known that calcium ion deregulation plays a critical role in apoptotic cell death. A calcium increase in the nuclei might lead to toxic effects in the cell. In this review, we highlight the relationship between induced disturbances of calcium homeostasis, genomic damage, and apoptotic cell death caused by arsenic and its organic derivatives.
A graph-based automatic services composition based on cost estimation heuristic (2019)

Currently, both software and hardware are being virtualised and offered as services on the internet. Companies have an opportunity to improve their workflows by composing services that best suit their quality and cost requirements. However, as more services become available, computer-aided services discovery and composition become essential. Traditional service representation and planning algorithms do not adequately address non-functional characteristics, large numbers of similar operators (i.e., services), and limited numbers of objects (i.e., inputs and outputs per service). This paper analyses existing work in automatic services composition, service representation and planning algorithms and proposes a new framework to address those needs. It proves that the proposed framework provides an admissible heuristic based on cost estimations that guarantee a minimum cost solution, if one exists.
Effect of pH and ionophores on the calcium-pumping ATPase of endoplasmic reticulum microsomes from guinea pig pancreas. (1987)

The effects of the proton-ionophore FCCP, the electroneutral calcium-proton ionophore A23187, pH and oxalate on calcium uptake and (Ca-Mg)ATPase activity were assayed in microsomal vesicles prepared from guinea pig pancreas. The results can be summarized as follows: 1) The optimum pH for ATP-dependent calcium uptake was 7, whereas the (Ca-Mg)ATPase activity was maximal at pH 7.5-8; 2) after a time lag of oxalate-insensitivity, oxalate stimulated strongly the ATP-dependent calcium uptake; 3) FCCP uncoupled the process of calcium uptake and ATP hydrolysis; 4) the effects of FCCP on calcium transport and ATPase activity were quite similar to those induced by the calcium ionophore A23187. These results can be explained by the formation of a proton gradient through membrane vesicles during the calcium pumping process.
253. Calcium ionophore induction of marmoset oocyte activation (2005)

The marmoset monkey (Callithrix jacchus) is a valuable model for developing assisted reproductive technologies in humans and endangered primate species. Calcium ionophore treatments have been used to induce parthenogenetic activation in a number of species, but the effectiveness of this reagent in initiating marmoset embryo development has not yet been reported. The aim of this study was to determine the developmental potential of in vitro matured (IVM) marmoset oocytes, following treatment with calcium ionophore. Immature oocytes from large (LA; &gt;1.5 mm) and small (SA; 0.67–1.5 mm) antral follicles were isolated from the ovaries of FSH-primed animals and cultured in modified G2 medium for 26–30 h at 37.0°C in 6% CO2 in air. Meiotically mature oocytes were sequentially incubated with 5 μM ionomycin for 5 min and 2 mM 6-dimethylaminopurine for 3 h and cultured in G1/G2 sequential medium at 37.0°C in 5% O2, 6% CO2, 89% N2 for 10 days. Cumulus cell expansion associated with LA oocytes (n=118) was greater than that of SA oocytes (n=212), as determined using well established classification criteria (2.7±0.1 v. 1.8±0.2; P&lt;0.01). A greater proportion of LA oocytes completed meiosis to the metaphase-II stage compared with SA oocytes (85±7% v. 63±7%; P&lt;0.05). Pronuclear formation was induced at similar rates in mature oocytes of both groups, but the rate of cleavage was higher for LA oocytes compared with SA oocytes (93±6% v. 66±5%; P&lt;0.05). The number of cells per embryo was not different between the groups.This is the first study to demonstrate that calcium ionophore effectively induces parthenogenetic activation in IVM marmoset oocytes. However, the development of parthenotes was limited beyond the 8-cell stage. Further studies are needed to determine the cause of the developmental block.
Distributed Finite Time Termination of Consensus in the Presence of Delays (2016)

Linear consensus iterations guarantee asymptotic convergence, thereby, limiting their applicability in applications where consensus value needs to be used in real time to perform a system level task. It also leads to wastage of power and communication resources. In this article, an algorithm is proposed which enables each node to detect in a distributed manner and in finite number of iterations, when every agent in the network is within a user specified threshold of the consensus value (approximate consensus) and hence terminate further communications and computations associated with consensus iterations. This article develops a distributed algorithm for achieving this approximate consensus in presence of random time-varying bounded communication delays. Moreover, the article instantiates the algorithm developed to distributively determine the average of the initial values held by agents in finite number of iterations. Specifically, this algorithm relies on distributively determining the maximum and minimum of values held by the agents. The approach presented here offers several advantages, including reduced computational complexity, and hence, is suited for hardware implementation. An experimental test bed of Raspberry-Pi agents that communicate wirelessly over neighborhoods is employed as a platform to demonstrate the effectiveness of the developed algorithm.
ChemInform Abstract: SIMPLE DE NOVO SYNTHESIS OF REACTIVE PSEUDO‐GLYCALS (HEX‐2‐ENOPYRANOSIDES) ‐ STEREOSPECIFIC α‐GLYCOSIDE LINKAGE (1978)

Abstract Die Diels‐Alder‐Reaktion von trans,trans‐Butadienylendiacetat (I) mit dem Glyoxalat (II) liefert ein 1:1‐Gemisch (75% Ausb.) aus den Uronsäureestern (III) und (IV), das nach dem cis‐Additionsprinzip primär entstehende β‐Anomere von (IV) isomerisiert unter den Reaktionsbedingungen vollständig zu (IV).
Patterns and Correlates of Cervical Cancer Screening Initiation in a Large Integrated Healthcare System [1K] (2018)

INTRODUCTION: The cervical cancer incidence rate has not declined among 24–25 year-olds between 2000 (2.79 per 100,000) and 2013 (2.93 per 100,000). We studied cervical cancer screening initiation in young women and how woman and provider factors affect the timing of screening initiation to effect prevention. We examined patterns and correlates of cervical cancer screening initiation among women turning age 21 in a large community-based practice. METHODS: Female members who turned age 21 (baseline) during 2013–2015 and had not previously received Papanicolaou (Pap) test were evaluated during 2016 using electronic health records. Incidence rate and cumulative incidence of screening initiation was calculated. Associations between patient and provider characteristics and screening initiation were evaluated using multivariable Cox models. RESULTS: Of 38,257 women studied, the Pap screening initiation rate was 44 per 100 person-year(s). Approximately 40% initiated screening within 1 year after turning age 21. I Asian/Pacific Islanders, Medicaid enrollees, those whose primary language is not English, those with a recent inpatient visit, those with a primary care physician (PCP) in specialties other than family practice, and those cared for by a male rather than female PCP less often initiated screening. History of Human Papilloma virus and flu vaccination, a history of pregnancy, contraception use, and sexually transmitted infections had more timely screening initiation. CONCLUSION: Less than half of the women insured for preventative services initiated screening at age 21. Strategies to improve adherence to screening initiation guidelines should consider a tailored approach for at risk subgroups and addressing initiation challenges associated with male physicians.
Waveguide Resonators with Distributed Bragg Reflectors (1982)

The transmission and reflection properties of a waveguide resonator with DBRs are described near and at the Bragg condition using the method of coupled waves. Different grating configurations characterized by their coupling coefficients, attentuation parameters, and geometric dimensions are included to investigate symmetrical and asymmetrical resonator configurations. Possibilities of realizing tunable systems and optically bistable devices are also mentioned.
Lack of Effectiveness of Cellulose Sulfate Gel for the Prevention of Vaginal HIV Transmission (2008)

Cellulose sulfate did not prevent HIV infection and may have increased the risk of HIV acquisition. (ClinicalTrials.gov number, NCT00153777; and Current Controlled Trials number, ISRCTN95638385.)
Munich atopy prediction study (MAPS): protocol for a prospective birth cohort addressing clinical and molecular risk factors for atopic dermatitis in early childhood (2022)

The study is approved by the Ethical Committee of the Medical Faculty of the Technical University of Munich (reference 334/16S). All relevant study results will be presented at national and international conferences and in peer-reviewed journals.
1,3‐Dipolar Cycloaddition of 5‐Substituted‐1‐Methyl‐3‐Oxidopyridiniums (1984)

Abstract 5‐Methoxy‐ and 5‐dimethylamino‐1‐methyl‐3‐oxidopyridiniums were shown to give the 1,3‐dipolar cycloadducts widely with methyl acrylate, acrylonitrile, N‐phenylmaleimide, styrene, phenylacetylene, cyclopentadiene, cyclopentene, diethyl azodicarboxylate and singlet oxygen.
Effects on bacon quality of feeding increasing glycerol and dried distillers grains with solubles to finishing pigs (2010)

A total of 84 barrows (PIC 337 x 1050, initially 68.3 lb) were fed a corn-soybean meal-based diet with added dried distillers grains with solubles (DDGS; 0 or 20%) and increasing glycerol (0, 2.5, or 5%) to determine the effects on belly quality. Criteria that were evaluated included: belly length, thickness, firmness, and slice yield; proximate and fatty acid analyses; iodine values; and sensory characteristics. There were no (P > 0.08) DDGS x glycerol interactions on any criteria measured. Inclusion of 20% DDGS in the diet decreased belly firmness (P < 0.04), as measured by the belly flop test (fat-side down method). Twenty percent DDGS decreased (P < 0.01) the percentage of myristic acid, palmitic acid, palmitoleic acid, stearic acid, oleic acid, vaccenic acid, total saturated fatty acids, and total monounsaturated fatty acids. In contrast, 20% DDGS increased (P < 0.01) the percentage of linoleic acid, Î±-linolenic acid, eicosadienoic acid, total polyunsaturated fatty acids, unsaturated:saturated fatty acid ratios, polyunsaturated:saturated fatty acid ratios, and iodine values. The inclusion of 0, 2.5, and 5% glycerol in swine diets did not affect any measured criteria in this study. In conclusion, feeding DDGS at a level of 20% decreased belly firmness and changed the fatty acid profile; however, it did not affect belly processing or sensory characteristics. Glycerol fed at 2.5 or 5.0% did not affect belly quality, fatty acid profile, or sensory characteristics of bacon.; Swine Day, Manhattan, KS, November 18, 2010
Predicting the Direction of Stock Market Index Movement Using an Optimized Artificial Neural Network Model (2016)

In the business sector, it has always been a difficult task to predict the exact daily price of the stock market index; hence, there is a great deal of research being conducted regarding the prediction of the direction of stock price index movement. Many factors such as political events, general economic conditions, and traders' expectations may have an influence on the stock market index. There are numerous research studies that use similar indicators to forecast the direction of the stock market index. In this study, we compare two basic types of input variables to predict the direction of the daily stock market index. The main contribution of this study is the ability to predict the direction of the next day's price of the Japanese stock market index by using an optimized artificial neural network (ANN) model. To improve the prediction accuracy of the trend of the stock market index in the future, we optimize the ANN model using genetic algorithms (GA). We demonstrate and verify the predictability of stock price direction by using the hybrid GA-ANN model and then compare the performance with prior studies. Empirical results show that the Type 2 input variables can generate a higher forecast accuracy and that it is possible to enhance the performance of the optimized ANN model by selecting input variables appropriately.
Domain-Partitioning Rankboost for Face Recognition (2007)

In this paper we propose a domain partitioning RankBoost approach for face recognition. This method uses Local Gabor Binary Pattern Histogram (LGBPH) features for face representation, and adopts RankBoost to select the most discriminative features. Unlike the original RankBoost algorithm in Freund et al. (2003), weak hypotheses in our method make their predictions based on a partitioning of the similarity domain. Since the domain partitioning approach handles the loss function of a ranking problem directly, it can achieve a higher convergence speed than the original approach. Furthermore, in order to improve the algorithm's generalization ability, we introduce some constraints to the weak classifiers being searched. Experiment results on FERET database show the effectiveness of our approach.
Channel Coding for Progressive Multimedia in a 2-D Time-Frequency Block of an OFDM System (2007)

Coding and diversity are very effective techniques for improving transmission reliability in a mobile wireless environment. The use of diversity is particularly important for multimedia communications over fading channels. In this work, we study the transmission of progressive image bitstreams using channel coding in a 2-D time-frequency resource block in an OFDM network, employing time and frequency diversities simultaneously. In particular, in the frequency domain, based on the order of diversity and the correlation of individual subcarriers, we construct symmetric ra-channel FEC-based multiple descriptions using channel erasure codes combined with embedded image coding. In the time domain, a concatenation of RCPC codes and CRC codes is employed to protect individual descriptions. We consider the physical channel conditions arising from various different coherence bandwidths and coherence times, leading to various orders of diversities available in the time and frequency domains. We also study the tradeoffs and the relative effectiveness associated with the use of erasure codes in the frequency domain and convolutional codes in the time domain under different physical environments.
Narrow-band search of continuous gravitational-wave signals from Crab and Vela pulsars in Virgo VSR4 data (2015)

In this paper we present the results of a coherent narrow-band search for continuous gravitational-wave signals from the Crab and Vela pulsars conducted on Virgo VSR4 data. In order to take into account a possible small mismatch between the gravitational-wave frequency and two times the star rotation frequency, inferred from measurement of the electromagnetic pulse rate, a range of 0.02 Hz around two times the star rotational frequency has been searched for both the pulsars. No evidence for a signal has been found and 95% confidence level upper limits have been computed assuming both that polarization parameters are completely unknown and that they are known with some uncertainty, as derived from x-ray observations of the pulsar wind torii. For Vela the upper limits are comparable to the spin-down limit, computed assuming that all the observed spin-down is due to the emission of gravitational waves. For Crab the upper limits are about a factor of 2 below the spin-down limit, and represent a significant improvement with respect to past analysis. This is the first time the spin-down limit is significantly overcome in a narrow-band search.
Visible-Light-Mediated Direct Decarboxylative Acylation of Electron-Deficient Heteroarenes Using α-Ketoacids (2019)

Acylation of electron-deficient heteroaromatic compounds has been developed using visible light. α-Ketoacids have been used as an efficient source of acyl radicals under photoredox conditions. The in situ generated acyl radicals from α-ketoacids have been coupled to a wide variety of electron-deficient heteroaromatic compounds in a Minisci type reaction. This method would be attractive to access biologically attractive molecules.
Diffusion of cyclic versus linear poly(oxyethylene) oligomers in poly(methyl methacrylate) by ATR-FTIR spectroscopy (2009)

Diffusion of linear and cyclic poly(oxyethylene) (POE) oligomers in poly(methyl methacrylate) (PMMA) matrix was investigated in situ using attenuated total reflectance (ATR) infrared (IR) spectroscopy technique. The temperatures of studies were 60 oC, 85 oC and 110 oC. A film of PMMA was solution-cast onto an ATR zinc selenide crystal and POE was added to the surface. The IR peak at 1109 cm-1 characteristic to ether bond present in POE was used for quantitative analysis. Deconvolution of this peak from IR spectra allowed us to determine the absorbance of diffusing component as a function of interdiffusion time. The data were fit using appropriate mathematical models from where the interdiffusion constants were extracted and used in diffusion interpretation. By looking at different molecular weight of cyclic and linear POE oligomers diffusing into high molecular weight PMMA matrix, it was possible to analyze how penetrant topology and its molecular weight are influencing the diffusion process. The results indicated that cyclic POE moves faster than linear analogous one and an increase in penetrant molecular weight slows down the interdiffusion. The knowledge gained from this study gives us a deeper understanding of transport behavior of low-molecular-weight additives, such as oligomers into polymer matrices and, in particular the influence of topology on diffusion.
Fourier transform technique with frequency filtering for optical thin-film design (1995)

A Fourier analysis of existing and potentially complex refractive index profiles is often useful in the resolution of thin-film design problems. Applications of a frequency-filtering technique, which consists of the suppression of undesired spatial frequencies from the refractive index profiles, are described. A new, extremely simple antireflection coating synthesis method based on this concept is proposed.
Physical and/or Chemical Compatibilization of Extruded Cellulose Nanocrystal Reinforced Polystyrene Nanocomposites (2013)

International audience
Supplementary Movie 1 from Lipid Rafts and Caveolin-1 Are Required for Invadopodia Formation and Extracellular Matrix Degradation by Human Breast Cancer Cells (2023)

Supplementary Movie 1 from Lipid Rafts and Caveolin-1 Are Required for Invadopodia Formation and Extracellular Matrix Degradation by Human Breast Cancer Cells
Trauma case mix and hospital payment: the potential for refining DRGs. (1991)

Uniform hospital discharge abstract data from Maryland were used to examine the homogeneity of trauma-related DRGs with respect to a well-established measure of injury severity, the Injury Severity Score (ISS). Thirty DRGs were identified as including trauma cases with a wide range of severity; for each of these DRGs, ISS explains a significant amount of variation in length of stay. By applying statistical techniques similar to those used to create the original DRG groupings, these 30 DRGs were subdivided by severity and age categories to create a new set of severity-modified DRGs. The potential effects of using DRGs and modified DRGs to pay for inpatient care within the Maryland state regionalized system of trauma care were examined. Payments based on regional averages per DRG and per modified DRG were compared to actual hospital charges regulated by the state's Health Services Cost Review Commission. Using average charges per DRG as a basis of payment, approximately !1.4 million (11 percent of total hospital charges) would be shifted from trauma centers to nontrauma centers. This shift represents an 18 percent loss in revenues to trauma centers and a 30 percent gain in revenues to nontrauma centers. Using a payment system based on severity-modified DRGs, trauma centers would still experience a net loss in revenues and the nontrauma centers a net gain, but the total amount of the shift would be reduced from $11.4 million to $9.8 million. The results argue for the need to explore alternative payment systems not strictly based on current DRGs. Because of DRGs do not adequately reflect severity differences, using them to pay hospitals will create financial incentives that discourage regionalization of trauma care.
اقبال کے ہاں رواداری کا تصور (2017)

Iqbal is a multi _dimensional poet cum philosopher. His prose and poetry convey a message of peace,tolerance,patience,respect of humanity, brotherhood and vast view of social life .He probits pregudicial attitude in all affairs of life including religion .To him biasness is an evil.Love and affection is the remedy of all ills and problems of a society.In this article,his views regarding significance of fairplay and positiveness in life have been described.