TREATMENT OF HYPERTHYROIDISM WITH PROPYLTHIOURACIL (1946)

Article1 November 1946TREATMENT OF HYPERTHYROIDISM WITH PROPYLTHIOURACILE. B. ASTWOOD, W. P. VANDERLAANE. B. ASTWOODSearch for more papers by this author, W. P. VANDERLAANSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-25-5-813 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe current differences of opinion regarding the best form of treatment for hyperthyroidism are a reflection of the fact that of the several effective methods which are available, none is devoid of significant disadvantages. Experience with the use of antithyroid compounds is sufficient to show that this is a highly effective form of treatment, but extensive clinical trials have been carried out only with one such drug, thiouracil. The disadvantage attending the use of this compound relates almost exclusively to its side effects,1the drug fever syndrome or some variant of it and agranulocytosis. The former reaction usually precludes the...Bibliography1. VAN WINKLEHARDYHAZELHINESNEWCOMERSHARPSISK WSMGRDCHSEAWN: The clinical toxicity of thiouracil, a survey of 5,745 cases, Jr. Am. Med. Assoc., 1946, cxxx, 343. Google Scholar2. ASTWOODVANDERLAAN EBWP: Thiouracil derivatives of greater activity for the treatment of hyperthyroidism, Jr. Clin. Endocrinol., 1945, v, 424. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Read at the Philadelphia meeting of the American College of Physicians, May 13-17, 1946.From the Joseph H. Pratt Diagnostic Hospital, the Boston Dispensary and the Department of Medicine, Tufts Medical School.Aided in part by grants from the Committee on Endocrinology of the National Research Council and from the American Cyanamid Company, Stamford, Connecticut.Propylthiouracil was supplied by Dr. S. M. Hardy of the Lederle Laboratories, Inc., Pearl River, New York. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHémorragie intra-alvéolaire induite par le propylthiouracilDrug-induced anti-neutrophil cytoplasmic antibody-associated vasculitisClinical Characteristics and Outcomes of Propylthiouracil-Induced Antineutrophil Cytoplasmic Antibody-Associated Vasculitis in Patients with Graves' Disease: A Median 38-Month Retrospective Cohort Study from a Single Institution in ChinaAntineutrophil Cytoplasmic Antibody–Positive Small-Vessel Vasculitis Associated with Antithyroid Drug Therapy: How Significant Is the Clinical Problem?Surgical Management of an Atypical Presentation of a Thyroid StormThe propylthiouracil dilemmaPropylthiouracilHepatite aguda colestática pelo propiltiouracil: relato de casoHepatite por propiltiouracil: apresentação de dois casos com evoluções diversasTed Astwood's Intellectual Legacy: Some Personal ViewpointsPropylthiouracil HepatotoxicityMetabolism of Thioamide Antithyroid DrugsWhich anti-thyroid drug?Propylthiouracil Levels in Hyperthyroid Patients Unresponsive to Large Doses Evidence of Poor Patient ComplianceDAVID S. COOPER, M.D.Fulminant Hepatitis and Lymphocyte Sensitization Due to PropylthiouracilMethimazole Toxicity from High DosesJAMES J. WIBERG, M.D., FRANK Q. NUTTALL, M.D., Ph.D., F.A.C.P.The Relative Toxicity of Antithyroid DrugsThe Thyroid Gland in PregnancyTHIOURACIL IN PREGNANCYThiourea Derivatives and the Fetus**Work supported in part by the Fiftieth Anniversary Fund of the Chicago Lying-in Hospital and the Benjamin J. Rosenthal Post Doctoral Fellowship in the Department of Pediatrics, University of Chicago.Diseases of the Thyroid GlandFATAL AGRANULOCYTOSIS DURING TREATMENT OF TOXIC GOITER WITH PROPYLTHIOURACIL*RICHARD T. BEEBE, M.D., F.A.C.P., SIMON PROPP, M.D., JOHN C. MCCLINTOCK, M.D., ARMAND VERSACI, M.D.The Effect of Propylthiouracil on the Periodontium of the HamsterPROPYLTHIOURACIL IN THE TREATMENT OF ANGINA PECTORIS: A COMPARISON WITH THIOURACIL THERAPY*SOLOMON BEN-ASHER, M.D.Clinical EndocrinologyThe Present Status of the Treatment of HyperthyroidismAgranulocytosis during propylthiouracil therapyStatus of antithyroid substances in thyroid diseaseHyperthyroidism and pregnancyDiscussion on the Treatment of Toxic GoitreTreatment of Hyperthyroidism with Methylthiouracil. 1 November 1946Volume 25, Issue 5Page: 813-821KeywordsAdverse reactionsClinical trialsDiagnostic medicineDrugsEndocrinologyFeversHospital medicineHyperthyroidismRivers ePublished: 1 December 2008 Issue Published: 1 November 1946 PDF downloadLoading ...