gebhart/patrepeval huggingface dataset:
Reactions of n-Heptane and Methylcyclopentane over an Oxygen-Modified Molybdenum Carbide Catalyst. Study of Coke Formation, Catalyst Deactivation, and Regeneration (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of n-Heptane and Methylcyclopentane over an Oxygen-Modified Molybdenum Carbide Catalyst. Study of Coke Formation, Catalyst Deactivation, and RegenerationPham-Huu Cuong, Andrew P. E. York, Mohamed Benaissa, Pascal Del Gallo, and Marc J. LedouxCite this: Ind. Eng. Chem. Res. 1995, 34, 4, 1107–1113Publication Date (Print):April 1, 1995Publication History Published online1 May 2002Published inissue 1 April 1995https://pubs.acs.org/doi/10.1021/ie00043a012https://doi.org/10.1021/ie00043a012research-articleACS PublicationsRequest reuse permissionsArticle Views301Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
F10 pandalid shrimp: Sex determination; DNA and dopamine as indicators of domestication; and outcrossing for wild pigment pattern (1993)

Abstract Domestication becomes significant in captive propagation of high‐fecundity animals which sustain significant mortality rates. The domestication process typical of higher vertebrates has been observed in the coonstripe shrimp, Pandalus danae , which were reared through 10 generations for study of protandric hermaphroditism. The research protocol of repeated handling, for determining sex and carapace length, rendered escape responses maladaptive. Domesticated, F 10 shrimp showed significantly greater band‐sharing in genomic DNA than wild shrimp, and the domesticated shrimp had only 5.5% of the dopamine levels in haemolymph found in wild shrimp. For both parameters, outcrossed shrimp (wild X domestic) had intermediate values. The outcrossed shrimp looked entirely wild, yet had behavioral and metabolic attributes of domestic shrimp. For such nonendangered species, domestication may be as desirable as it is unavoidable. It appears necessary, however, to perform outcrossing in order to maintain the wild form. © 1993 Wiley‐Liss, Inc.
EDDY CURRENT INSPECTION OF COMPONENTS WITH COMPLEX GEOMETRIES (2008)

Eddy current (EC) technique is a common inspection method for the detection of open surface cracks and subsurface anomalies. While manual EC inspection is quite reliable on parts with flat (or large curvature) surfaces and parts with consistent subsurface geometry, EC inspection of parts having more complicated surface and subsurface profiles has to rely on automated scan/data collection and post‐processing. Examples of the structures with complex geometries are aircraft engine rotating parts and multi‐layer aircraft structures (lap joints). Data collection for such structures, in most cases, can be performed by using multiple scans of a single sensor EC probe with multi‐frequency excitation. To improve productivity of the inspection, arrays of EC sensors are applied during inspection for surface flaws. In this work, the flexible ECAP (EC array probe) with sensitivity to the cracks of variable orientations is presented. To resolve the complex subsurface geometry of the aircraft skin, pulsed excitation is employed. This makes for a faster data collection and full post‐processing capabilities. Conversion to multi‐frequency (multi‐layer) image analysis is done after data collection is completed. The subsurface flaws present in a particular layer of a riveted lap joint become evident from several EC images, which cannot be accomplished by manual inspection.
Effect of Single and Combined Expression of Lysophosphatidic Acid Acyltransferase, Glycerol-3-Phosphate Acyltransferase, and Diacylglycerol Acyltransferase on Lipid Accumulation and Composition in Neochloris oleoabundans (2019)

Microalgal lipids are promising feedstocks for food and biofuels. Since lipid production by microalgae is not yet economically feasible, genetic engineering is becoming a promising strategy to achieve higher lipid accumulation and productivities. Enzymes involved in the Kennedy pathway such as glycerol-3-phosphate acyltransferase (GPAT), lysophosphatidic acid acyltransferase (LPAT), and diacylglycerol acyltransferase (DGAT) catalyze key steps in the formation of triacylglycerol, which is the main constituent of lipids in <i>N. oleoabundans</i>. The overexpression of these enzymes in the targeted strain has a great potential to further increase their triacylglycerol content. We overexpressed single and multiple encoding genes for <i>LPAT</i>, <i>GPAT</i>, and <i>DGAT</i> from <i>Acutodesmus obliquus</i> in <i>N. oleoabundans</i>. Strains overexpressing single genes produced up to 52% and 45% g · gDW<sup>-1</sup>, which corresponds to 1.3- and 1.4-fold increase in total fatty acids and triacylglycerols, respectively. The orchestrated expression of the three genes resulted in 49% and 39% g · gDW<sup>-1</sup>, which is 1.2-folds increase in total fatty acids and triacylglycerols. Single expression of <i>LPAT</i>, <i>GPAT,</i> and <i>DGAT</i> genes resulted in higher lipid productivities during starvation without a significant effect on growth and photosynthetic activity during replete conditions. On the other hand, the simultaneous expression of <i>LPAT</i>, <i>GPAT,</i> and <i>DGAT</i> genes resulted in 52% lower growth rate, 14% lower photosynthetic activity and 4-folds increase in cell diameter. Moreover, the multigene expressing line showed a decrease in carbohydrates and protein content and an increase in pigments during nitrogen starved condition. The single and multiple expression of heterologous genes <i>LPAT</i>, <i>GPAT,</i> and <i>DGAT</i> showed to significantly enhanced the lipid accumulation in <i>N. oleoabundans</i>. Single gene expression resulted in higher lipid production and productivities without having a significant impact in the physiological status of the strains. This approach shows the potential for the generation of microalgal strains with higher economical potential for the production of lipids.
[Growth factors in the pituitary gland]. (1993)

There are increasing numbers of evidence that many factors, such as growth factors and cytokines, exist in the pituitary gland, and modulate the release of pituitary hormone both in vivo and in vitro. They indicate the importance of autocrine and paracrine control system within the pituitary gland. For instance, activin, a compound whose existence and nature (in contrast to the related protein inhibin) was not contemplated before its discovery in 1986, has been shown to be synthesized in gonadotrophs and to produce diverse effects on the anterior pituitary. We would like to introduce some recent studies on growth factors in the pituitary gland.
Scattering of Waves by Conducting and Dielectric Objects (2017)

In radar, the radio wave is transmitted toward an object and the scattered wave received by an antenna reveals the characteristics of the object, such as its position and motion. This chapter develops basic formulations of the scattering problem, discusses possible potential applications. When an object is illuminated by a wave, a part of the incident power is scattered out and another part is absorbed by the object. The characteristics of these two phenomena, scattering and absorption, can be expressed by assuming an incident plane wave. The chapter discusses the scattering characteristics of a conducting body, particularly the backscattering cross section for radar applications. It presents an overall view of how these cross sections are related to the geometric cross section, wavelength, and dielectric constant. The chapter describes the physical optics approximation to give a convenient expression for the surface current, and thus it is widely used for many applications.
Estimates of milk constituents from lactating bonnet macaque (Macaca radiata) mothers between two and seven months post‐partum (2010)

The composition of the milk of this particular macaque species was similar to other Old World primates as well as humans. These data add to the limited information available on milk constituents among mammals.
Enamine Chemistry. VI. Reactions with Propiolates1 (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnamine Chemistry. VI. Reactions with Propiolates1Kent C. Brannock, Robert D. Burpitt, V. Wilson Goodlett, and John G. ThweattCite this: J. Org. Chem. 1964, 29, 4, 818–823Publication Date (Print):April 1, 1964Publication History Published online1 May 2002Published inissue 1 April 1964https://pubs.acs.org/doi/10.1021/jo01027a011https://doi.org/10.1021/jo01027a011research-articleACS PublicationsRequest reuse permissionsArticle Views428Altmetric-Citations54LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Collision-avoidance algorithm for human-symbiotic robot (2010)

A real-time collision-avoidance algorithm for human-symbiotic robots that are required to avoid multiple pedestrians was developed. An algorithm to predict the likelihood of a collision with obstacles was based on the relative velocities between a moving robot and multiple obstacles. An algorithm that can generate the optimum path sequence to a goal in real time was also developed. The collision-avoidance path is generated by repeating an operation to select two tangent paths that connect a via-point on a path to a collision circle of each obstacle that exists in the relative space. A robot-called EMIEW”-using these algorithms with a system for avoiding collisions with many obstacles moves at a speed of 0.8 m/s in a cluster of five people walking at 1.2 m/s. The repeat period for generating a new avoidance path is 0.5s, and the processing time for the developed algorithm in the each period is a maximum of 4 ms.
Borrelia burgdorferi binds plasminogen, resulting in enhanced penetration of endothelial monolayers (1995)

Several strains of Borrelia burgdorferi and Borrelia hermsii can bind human Lys-plasminogen specifically. Affinity blots using 125I-labeled plasminogen showed that numerous polypeptides of all the strains and species tested could bind via lysine residues to the plasminogen molecule since binding could be completely inhibited by the lysine analog epsilon-aminocaproic acid. Binding analysis using 125I-labeled plasminogen on live intact organisms showed that the organisms possess two binding sites for plasminogen: a high-affinity site with a Kd of 24 +/- 12 pM and 106 +/- 14 binding sites per spirochete and a low-affinity site with a Kd of 20 +/- 4 nM and 2,683 +/- 36 binding sites per spirochete. Indirect immunofluorescence and confocal microscopy showed a generalized but punctate pattern of plasminogen binding to the spirochete surface. Exogenously provided urokinase-type plasminogen activator converted B. burgdorferi surface-bound plasminogen to enzymatically active plasmin as demonstrated by the breakdown of the chromogenic plasmin substrate S2251. Plasmin-coated organisms showed an enhanced ability to penetrate endothelial cell monolayers grown on connective tissue substrates compared to untreated controls (P &lt; 0.001). This functional assay demonstrated that enzymatically active plasmin on the surface of spirochetes can lead to greater invasion of tissues.
Autonomic computing system for self-management of machine-to-machine networks (2012)

The internet of things consists of a high amount of heterogeneous objects that are widely distributed and evolve frequently according to their context changes. Management of such a complex environment is costly in terms of time and money. Machine to Machine (M2M) networks will soon become virtually impossible to administer. Designing context aware autonomic system for M2M networks with capability of self-management is a challenge. This paper proposes an autonomic computing system based on standardized M2M architecture and composed of generic and extensible autonomic managers. Autonomic managers communicate with each other to enable self-management of application, service and communication layers based on knowledge models and reasoning rules. A smart metering use case is experimented to illustrate the proposed solution.
Critical Magnetic Field Strength for Suppression of the Richtmyer-Meshkov Instability in Plasmas (2013)

The critical strength of a magnetic field required for the suppression of the Richtmyer-Meshkov instability (RMI) is investigated numerically by using a two-dimensional single-mode analysis. For the cases of magnetohydrodynamic parallel shocks, the RMI can be stabilized as a result of the extraction of vorticity from the interface. A useful formula describing a critical condition for magnetohydrodynamic RMI is introduced and is successfully confirmed by direct numerical simulations. The critical field strength is found to be largely dependent on the Mach number of the incident shock. If the shock is strong enough, even low-β plasmas can be subject to the growth of the RMI.
Noonan's syndrome: report of a case with oral findings. (1979)

Abstract : A case of Noonan's syndrome in a 6-year-old boy is presented in which xanthomas of the skin and tongue were an additional, not previously reported, finding. The other syndromal stigmata are essentially those reported by Noonan and others in the literature.
Anatomy of a Puppy Mill Raid (2013)

An estimated 10,000 U.S. puppy mills breed animals in squalid conditions. Shutting each one down is a struggle all its own.
"Pseudo-ascites" associated with giant ovarian cysts and elevated cystic fluid amylase. (1983)

Two patients with massive ovarian cysts that mimicked ascites on physical examination, ultrasonography, and abdominal plain film are reported. Elevated cyst amylase in both patients, and in one, elevated serum amylase, further confused the diagnosis. Massive ovarian cysts should be considered in the differential diagnosis of presumed ascites in female patients, particularly in the setting of elevated serum or "ascitic" fluid amylase.
EVALUATION OF INSECTICIDE ROTATIONS WITH SULFOXAFLOR (GF-2372) AGAINST TARNISHED PLANT BUGS IN COTTON, 2010 (2011)

Tarnished plant
Performance of the Quantum Approximate Optimization Algorithm on the Maximum Cut Problem (2018)

The Quantum Approximate Optimization Algorithm (QAOA) is a promising approach for programming a near-term gate-based hybrid quantum computer to find good approximate solutions of hard combinatorial problems. However, little is currently know about the capabilities of QAOA, or of the difficulty of the requisite parameters optimization. Here, we study the performance of QAOA on the MaxCut combinatorial optimization problem, optimizing the quantum circuits on a classical computer using automatic differentiation and stochastic gradient descent, using QuantumFlow, a quantum circuit simulator implemented with TensorFlow. We find that we can amortize the training cost by optimizing on batches of problems instances; that QAOA can exceed the performance of the classical polynomial time Goemans-Williamson algorithm with modest circuit depth, and that performance with fixed circuit depth is insensitive to problem size. Moreover, MaxCut QAOA can be efficiently implemented on a gate-based quantum computer with limited qubit connectivity, using a qubit swap network. These observations support the prospects that QAOA will be an effective method for solving interesting problems on near-term quantum computers.
Nicotinamide Riboside Kinase Structures Reveal New Pathways to NAD+ (2007)

The eukaryotic nicotinamide riboside kinase (Nrk) pathway, which is induced in response to nerve damage and promotes replicative life span in yeast, converts nicotinamide riboside to nicotinamide adenine dinucleotide (NAD+) by phosphorylation and adenylylation. Crystal structures of human Nrk1 bound to nucleoside and nucleotide substrates and products revealed an enzyme structurally similar to Rossmann fold metabolite kinases and allowed the identification of active site residues, which were shown to be essential for human Nrk1 and Nrk2 activity in vivo. Although the structures account for the 500-fold discrimination between nicotinamide riboside and pyrimidine nucleosides, no enzyme feature was identified to recognize the distinctive carboxamide group of nicotinamide riboside. Indeed, nicotinic acid riboside is a specific substrate of human Nrk enzymes and is utilized in yeast in a novel biosynthetic pathway that depends on Nrk and NAD+ synthetase. Additionally, nicotinic acid riboside is utilized in vivo by Urh1, Pnp1, and Preiss-Handler salvage. Thus, crystal structures of Nrk1 led to the identification of new pathways to NAD+.
Resource management in MPLS applied ATM network (2002)

When an IP packet travels in the network, the packet header always carries excess information for routing. To improve the efficiency of packet routing and QoS requirement, MPLS technology is put forward. It can be applied to different network environments and the ATM network is just one of them. Due to the features of MPLS, resource management has its own characteristics. There have been proposed many resource management algorithms in ATM networks, considering, which and the properties of MPLS, we suggest some preferable resource management methods that are suitable for this situation by comparing different bandwidth control schemes. The main point of this paper is that we adopt a dynamic allocating/de-allocating source control mechanism, and guarantee traffic on per-VC bases which may bring a better isolation of different streams, and thus decrease the interference between them.
Utility of restaging bone marrow biopsy (BMB) in PET-negative patients with diffuse large B-cell lymphoma (DLBCL) with bone marrow involvement. (2014)

8541 Background: Less than 10% of DLBCL patients have stage IV disease with BM involvement at diagnosis. For these patients, restaging BMB is required to document complete remission (CR). In addition to cost, BMB is a potential source of anxiety and pain for patients. PET-CT is the standard for response assessment in DLBCL and may accurately detect BM involvement at diagnosis (Khan 2013). This raises the question of whether BM assessment on restaging PET-CT could obviate the need for repeat BMB. Methods: This was a single institution, retrospective cohort study. After IRB approval, patients with DLBCL and a positive BMB at diagnosis were identified from the Mayo Clinic Lymphoma Data Base. The concordance of BM status on restaging histopathology and PET-CT reports and the positive (PPV) and negative predictive value (NPV) of PET-CT were determined. Findings were validated in a prospective cohort of 68 DLBCL patients treated on an ongoing phase II clinical trial of frontline lenalidomide and RCHOP (R2CHOP). Results: Between 2004 and 2013, 1080 patients with DLBCL were evaluated. Of those, 69 (6%) had DLBCL involving the BM at diagnosis. Forty-six patients completed frontline chemoimmunotherapy; 8 were lost to follow-up; and 15 did not complete therapy because of death or progression. Of 46 patients completing therapy, 31 had restaging PET-CT and BMB and were included in the analysis. The concordance between BMB and PET-CT was 100%. Thirty patients had a negative BM by PET-CT and BMB (29 CR; 3PR; 1PD). One patient had persistent BM involvement by biopsy and PET-CT. Thus, restaging PET-CT had 100% PPV and 100% NPV for assessing residual BM disease. In the validation cohort, four patients (6%) had DLBCL involving the BM at diagnosis. All had a negative BM by both restaging BMB and PET-CT. Conclusions: Compared with the gold standard of BMB, PET-CT had a 100% NPV to exclude residual BM disease in DLBCL patients after frontline therapy. These findings are being further studied in ECOG1412 testing RCHOP vs R2CHOP in untreated DLBCL. If further validated, DLBCL practice guidelines and response criteria could be modified so BMB is no longer required to document CR if the restaging PET-CT is negative.
SPIRONOLACTONE ALLEVIATES ISCHEMIC STROKE SEVERITY IN MALE MICE WITH CHRONIC KIDNEY DISEASE (2020)

57th ERA-EDTA Congress, ELECTR NETWORK, JUN 06-09, 2020
Drug response profiles in patient-derived cancer cells across histological subtypes of ovarian cancer: real-time therapy tailoring for a patient with low-grade serous carcinoma (2022)

Many efforts are underway to develop novel therapies against the aggressive high-grade serous ovarian cancers (HGSOCs), while our understanding of treatment options for low-grade (LGSOC) or mucinous (MUCOC) of ovarian malignancies is not developing as well. We describe here a functional precision oncology (fPO) strategy in epithelial ovarian cancers (EOC), which involves high-throughput drug testing of patient-derived ovarian cancer cells (PDCs) with a library of 526 oncology drugs, combined with genomic and transcriptomic profiling. HGSOC, LGSOC and MUCOC PDCs had statistically different overall drug response profiles, with LGSOCs responding better to targeted inhibitors than HGSOCs. We identified several subtype-specific drug responses, such as LGSOC PDCs showing high sensitivity to MDM2, ERBB2/EGFR inhibitors, MUCOC PDCs to MEK inhibitors, whereas HGSOCs showed strongest effects with CHK1 inhibitors and SMAC mimetics. We also explored several drug combinations and found that the dual inhibition of MEK and SHP2 was synergistic in MAPK-driven EOCs. We describe a clinical case study, where real-time fPO analysis of samples from a patient with metastatic, chemorefractory LGSOC with a CLU-NRG1 fusion guided clinical therapy selection. fPO-tailored therapy with afatinib, followed by trastuzumab and pertuzumab, successfully reduced tumour burden and blocked disease progression over a five-year period. In summary, fPO is a powerful approach for the identification of systematic drug response differences across EOC subtypes, as well as to highlight patient-specific drug regimens that could help to optimise therapies to individual patients in the future.