gebhart/patrepeval huggingface dataset:
Ability of insulin to increase calcium uptake by adipocyte endoplasmic reticulum. (1978)

The endoplasmic reticulum of adipocytes possess an ATPdependent calcium uptake system (Bruns, I). E., McDonald, J. M., and Jarett, L. (1976) J. Bid. Chem. 251, 7191-7197) which is shown in this report to be regulated by insulin treatment of intact adipocytes. Insulin (100 microunitslml) treatment of cells resulted in a 20% (p < 0.025 to 0.001 at various time points) increase in the steady state calcium filling capacity of endoplasmic reticulum. This insulin effect was specific as determined by the insulin-concentration dependency between 5 and 100 microunits of insulin/ml and by the lack of effect by desoctapeptide insulin. This increase resulted from a 28% (p < 0.025) increase in the apparent V,,,,, of calcium uptake. Insulin treatment had no affect on the K,,, (1.4 PM) of the reaction nor on the rate of calcium efflux from the vesicles when efflux was initiated by either ethylene glycol bis(/3-aminoethyl ether)N,N’-tetraacetic acid or the calcium ionophore A23187. Consistent with these changes, insulin treatment of cells resulted in a 33% (p < 0.001) increase in the atomic absorption measurements of the total calcium content of the microsomal fraction. The total calcium content of the microsomal fraction consisted of a highly stable pool and a less stable or labile pool. Only the labile pool was altered by insulin treatment, and the insulin-induced change represented a 50% increase of this pool. Insulin treatment had no effect on the magnesium content of the microsomal fraction. These findings support the concept that the calcium uptake system of the endoplasmic reticulum of adipocytes is likely to be physiologically important. Furthermore insulin regulation of intracellular calcium pools probably plays an essential role in the mechanism of insulin action.
Synthesis and Characterization of Poly(Acrylamide-co-2-Acrylamido-2-Methylpropane Sulfonic Acid)/Kaolin Superabsorbent Composite (2013)

A novel poly(acrylamide-co-2-acrylamido-2-methylpropane sulfonic acid)/kaolin (P(AM-co-AMPS)/kaolin) superabsorbent composite was synthesized by copolymerization reaction of acrylamide (AM), 2-acrylamido-2-methylpropane sulfonic acid (AMPS) and kaolin using ammonium persulfate (APS) as an initiator and N,N’-methylenebisacrylamide (NMBA) as a crosslinker in an aqueous solution. Evidence of the reaction between kaolin and P(AM-co-AMPS) copolymer was confirmed by comparing the Fourier transform infrared (FTIR) spectra of kaolin, P(AM-co-AMPS) copolymer and P(AM-co-AMPS)/kaolin superabsorbent composite. The reaction was also confirmed by scanning electron microscopy (SEM). Effects of APS, NMBA and kaolin concentrations, weight ratio of AM/AMPS and reaction temperature on water absorbency were investigated. The superabsorbent composite synthesized under the optimum synthesis conditions exhibits the maximum water absorption of 1678 g/g in distilled water and 141 g/g in 0.9 wt% NaCl solution. Results obtained from this study show that P(AM-co-AMPS)/kaolin superabsorbent composite has good water and salt solution absorbency at a relatively high temperature. The gel strength of the superabsorbent composite is significantly increased by increasing the concentration of kaolin.
Parameter Selection Guidelines for Direct-on-Line Permanent Magnet Generators Contemplating Fault-Ride-Through Capability (2022)

Direct-on-line (DOL) driven permanent-magnet generators (PMSGs) are often applied in small-scale hydropower plants (< 10 MW). The Commission Regulation (EU) 2016/631 defines the boundary conditions to operate these generators in parallel with the grid. According to the regulation, fault-ride-through (FRT) capability is required in some cases. FRT scenario of PMSGs was studied by simulations and the importance of machine parameters was analyzed. Machine parameters under interest are damper winding resistance and leakage inductance, stator resistance and leakage inductance, saliency, source voltage, total inductance and system inertia. Authors proved that fault-ride-through can be achieved by utilizing smart machine parameters selection without using complicated control systems and auxiliary equipment. FRT simulations are performed for three PMSGs and their capabilities are explored. Results can be used as a guideline in DOL PMSG design for satisfying FRT requirements. The simulation system was also verified with measurements of a 600 kW PMSG data during a fault situation: an incident where the generator was connected to the grid in phase opposition.
Strain-free GaSb quantum dots as single-photon sources in the telecom S-band (2023)

Creating single photons in the telecommunication wavelength range from semiconductor quantum dots (QDs) and interfacing them with spins of electrons or holes has been of high interest in recent years, with research mainly focusing on indium based QDs. However, there is not much data on the optical and spin properties of galliumantimonide (GaSb) QDs, despite it being a physically rich system with an indirect to direct bandgap crossover in the telecom wavelength range. Here, we investigate the (quantum-) optical properties of GaSb quantum dots, which are fabricated by filling droplet-etched nanoholes in an aluminum-galliumantimonide (AlGaSb) matrix. We observe photoluminescence (PL) features from isolated and highly symmetric QDs that exhibit narrow linewidth in the telecom S-band and show an excitonic fine structure splitting of $ΔE=(12.0\pm0.5)μeV$. Moreover, we perform time-resolved measurements of the decay characteristics of an exciton and measure the second-order photon autocorrelation function of the charge complex to $g^{(2)}(0)=0.16\pm0.02$, revealing clear antibunching and thus proving the capability of this material platform to generate non-classical light.
Square Planar Bis{3,6-bis(trimethylsilyl)benzene-1,2-dithiolato}metal Complexes of CrII, CoIII, and RhII: An Experimental and Density Functional Theoretical Study (2009)

The three square planar complexes [N(n-Bu)(4)](2)[Cr(II)L(2)] x 4 CH(3)CN (S = 2; 1), [N(n-Bu)(4)][Co(III)L(2)] (S = 1; 3), and [N(n-Bu)(4)](2)[Rh(II)L(2)] x 4 CH(3)CN (S = 1/2; 4) have been prepared and structurally characterized by X-ray crystallography (L(2-) represents the 3,6-bis(trimethylsilyl)benzene-1,2-dithiolate(2-)). Aerial oxidation of CH(2)Cl(2) solutions of 1 produced purple crystals of [N(n-Bu)(4)][Cr(V)OL(2)] x 2 CH(2)Cl(2) (S = 1/2; 2), the structure of which has also been determined by X-ray crystallography. The electro- and magnetochemistry of all species has been studied. Their electronic structures have been experimentally investigated by recording their electronic and EPR spectra; solid-state temperature-dependent magnetic susceptibility measurements have been performed. Density functional theoretical calculations at the ZORA-B3LYP level have been carried out for all four species in order to obtain a better understanding of the electronic structure of the square planar complexes and the one-electron reduced [Rh(I)L(2)](3-) species. The reactivity of the latter with CH(3)I has been studied, and two products have been identified: cis-[Rh(III)I(2)(L'')(L')] and cis-[Rh(III)(CH(3))(I)(L'')(L')] where (L')(-) represents the S-methylated monoanion of L(2-) and (L'')(0) is the neutral, twice-S-methylated form of (L)(2-).
Molecular cloning and expression of an abundant rabbit ovarian protein with 20 alpha-hydroxysteroid dehydrogenase activity. (1993)

An abundant 37-kDa protein, which comprises up to 30% of the soluble proteins of the ovary, has been found to have 20 alpha-hydroxysteroid dehydrogenase (20 alpha HSD) activity. The steroidogenic enzyme 20 alpha HSD regulates the conversion of progesterone to 20 alpha-hydroxyprogesterone in many mammalian species. Complimentary DNA clones encoding a unique and abundant 20 alpha HSD were isolated from a mature rabbit ovary library using guinea pig antisera generated to the purified 37-kDa protein and from a 5' EcoRI fragment from the initial positive clone. A full-length cDNA clone of 1217 basepairs encoding a 323-amino acid protein with an estimated mol wt of 37 kilodaltons was obtained. Amino acid sequence data indicate a similarity to human chlordecone reductase, bovine lung prostaglandin F synthase, human aldose reductase, human aldehyde reductase, and frog lens rho-crystallin, placing rabbit ovarian 20 alpha HSD in the aldo-keto reductase family of proteins. Northern blot analysis demonstrated a 1.2-kilobase mRNA in the interstitial tissue of mature rabbit ovaries and, to a lesser extent, in corpora luteal tissue. 20 alpha HSD was expressed in bacteria as a recombinant protein and was shown to possess enzymatic activity, preferring NADP as a cofactor. These studies demonstrate that an abundant ovarian protein belonging to the superfamily of NADP-dependent aldo-keto reductases has 20 alpha HSD activity. This is the first example of an abundant crystallin-related protein with known enzymatic activity in a tissue other than the lens.
Orcadian Variation and Onset Mechanisms of Ventricular Tachyarrhythmias in Patients with Coronary Disease Versus Idiopathic Dilated Cardiomyopathy (2000)

To determine the circadian variations and the onset mechanisms of ventricular tachyarrhythmias (VT) in patients with implantable cardioverter defibrillators, stored electrograms of 364 VT episodes occurring in 40 patients with coronary artery disease (CAD) and in 29 patients with idiopathic dilated cardiomyopathy (DCM) were analyzed. A similar circadian distribution of VT episodes was observed in both groups, with a morning peak and less pronounced evening peak. After exclusion of patients with atrial fibrillation, VT onset was classified as (1) sudden if preceded by > or = 8 regular cycles without ventricular premature beats, (2) onset with a short-long-short interval, and (3) a more complex onset with variable patterns of ventricular premature beats before initiation of VT. Sudden onset was found in 26% and 21% of VTs in CAD and DCM respectively. A short-long-short interval preceded 29% of VTs in CAD compared to 14% of VTs in DCM (P < 0.05). A more complex onset was observed in the remaining 45% of VTs in CAD and 65% of VTs in DCM (P < 0.05). In conclusion, patients with DCM and CAD had similar circadian distributions of VT episodes. The majority of episodes were preceded by complex occurrence of ventricular premature beats rather than by the classic short-long-short sequence. These findings have important implications for the development of preventive pacing methods.
Multimodal Machine Learning: A Survey and Taxonomy (2017)

Our experience of the world is multimodal - we see objects, hear sounds, feel texture, smell odors, and taste flavors. Modality refers to the way in which something happens or is experienced and a research problem is characterized as multimodal when it includes multiple such modalities. In order for Artificial Intelligence to make progress in understanding the world around us, it needs to be able to interpret such multimodal signals together. Multimodal machine learning aims to build models that can process and relate information from multiple modalities. It is a vibrant multi-disciplinary field of increasing importance and with extraordinary potential. Instead of focusing on specific multimodal applications, this paper surveys the recent advances in multimodal machine learning itself and presents them in a common taxonomy. We go beyond the typical early and late fusion categorization and identify broader challenges that are faced by multimodal machine learning, namely: representation, translation, alignment, fusion, and co-learning. This new taxonomy will enable researchers to better understand the state of the field and identify directions for future research.
NIMG-31. NON-DIPG PATIENTS ENROLLED IN THE INTERNATIONAL DIPG REGISTRY: HISTOPATHOLOGIC EVALUATION OF CENTRAL NEURO-IMAGING REVIEW (2020)

Abstract INTRODUCTION The role of diagnostic biopsy in diffuse intrinsic pontine glioma (DIPG) remains in question. Distinguishing radiographically between DIPG and other pontine tumors with more favorable prognosis and different therapy is critically important. METHODS Cases submitted to the International DIPG registry with histopathologic data were analyzed. Central imaging review was performed on diagnostic brain MRI (if available) by two neuro-radiologists; all cases with imaging features or histopathology suggestive of alternative diagnoses were re-reviewed. Imaging features suggestive of alternative diagnoses included non-pontine origin, &amp;lt; 50% pontine involvement (without typical DIPG pattern on follow-up), focally exophytic morphology, sharply-defined margins, or marked diffusion restriction throughout. RESULTS Among 294 patients with pathology from biopsy and/or autopsy available, 27 (9%) had histologic diagnoses not consistent with DIPG, most commonly pilocytic astrocytomas (n=11) and embryonal tumors (n=9). Of these 294 patients with biopsy and/or autopsy pathologic data, 163 also had diagnostic MRI available for central neuroimaging review and radiographic comparison. Among 81 patients classified as characteristic of DIPG, 80 (99%) had histopathology consistent with DIPG (diffuse midline glioma, H3K27M-mutant, glioblastoma, anaplastic astrocytoma, diffuse astrocytoma). Among 63 patients classified as likely DIPG, but with unusual imaging features, 59 (94%) had histopathology consistent with DIPG. Nineteen patients had imaging features suggestive of another diagnosis, including 13 with non-pontine tumor origin; the remaining 6 patients all had histopathology not consistent with DIPG (embryonal tumors [n=3, including 1 with medulloblastoma], pilocytic astrocytoma [n=1], and ganglioglioma [n=1]). Association between central imaging review and histopathology was significant (p &amp;lt; 0.001 by the Freeman-Halton Fischer Exact Probability Test). CONCLUSIONS The important role and accuracy of central neuroimaging review in diagnosing or excluding DIPG is demonstrated. In patients with pontine tumors for which DIPG is felt unlikely radiographically, biopsy may be considered to guide diagnosis, prognosis, and treatment.
Two-Way CO2-Switchable Triblock Copolymer Hydrogels (2012)

CO2-responsive ABA triblock copolymer hydrogels are described. Through rational block copolymer design, these hydrogels could undergo either CO2-induced gel-to-sol or the reverse sol-to-gel transition. While the middle block B is water-soluble, the solubility of the two end blocks A can be switched by CO2. For the gel-to-sol transition, the A block was made to have a lower critical solution temperature (LCST) that can increase upon CO2 bubbling, while for the sol-to-gel transition, the A block was designed to have a LCST that decreases with CO2. Repeated cycles of hydrogel formation and dissociation could be achieved by simply passing CO2 and an inert gas alternately through the solution, at a constant temperature and without adding acids and bases for pH change. Moreover, CO2-induced release of an encapsulated protein was demonstrated.
Ultrasound-mediated drug delivery by gas bubbles generated from a chemical reaction (2017)

Highly echogenic and ultrasound-responsive microbubbles such as nitrogen and perfluorocarbons have been exploited as ultrasound-mediated drug carriers. Here, we propose an innovative method for drug delivery using microbubbles generated from a chemical reaction. In a novel drug delivery system, luminol encapsulated in folate-conjugated bovine serum albumin nanoparticles (Fol-BSAN) can generate nitrogen gas (N<sub>2</sub>) by chemical reaction when it reacts with hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>), one of reactive oxygen species (ROS). ROS plays an important role in the initiation and progression of cancer and elevated ROS have been observed in cancer cells both in vitro and in vivo. High-intensity focussed ultrasound (HIFU) is used to burst the N<sub>2</sub> microbubbles, causing site-specific delivery of anticancer drugs such as methotrexate. In this research, the drug delivery system was optimised by using water-soluble luminol and Mobil Composition of Matter-41 (MCM-41), a mesoporous material, so that the delivery system was sensitive to micromolar concentrations of H<sub>2</sub>O<sub>2</sub>. HIFU increased the drug release from Fol-BSAN by 52.9 ± 2.9% in 10 minutes. The cytotoxicity of methotrexate was enhanced when methotrexate is delivered to MDA-MB-231, a metastatic human breast cancer cell line, using Fol-BSAN with HIFU. We anticipate numerous applications of chemically generated microbubbles for ultrasound-mediated drug delivery.
Modeling Minority Carriers Related Capacitive Effects for Transient Substrate Currents in Smart Power ICs (2015)

This paper presents an extended model for transient and ac circuit-level simulation of minority carriers propagation through the substrate of smart power integrated circuits (ICs). A p-n junction and a diffusion resistor with capacitive components are proposed to efficiently simulate transient parasitic coupled currents in high-power stages. From a general chip layout, an equivalent substrate network including capacitive effects (junction and diffusion capacitances) can be extracted and parasitic bipolar transistor can be simulated for the first time in transient operation by circuit simulators once the minority carriers continuity conditions are satisfied. This paper shows simulation results of the implemented models in good agreement with those obtained from technology computer-aided design. This implies that transient layout dependent mechanisms between high-voltage aggressor wells and low-voltage victims can be verified in early stages of IC design flow.
Genetic diversity of related vibriophages isolated from marine environments around Florida and Hawaii, USA (1995)

Although viruses from the marine environment have been enumerated, isolated, and characterized, there is little information on the abundance or global distribution of specific phage types. To this end, we studied the abundance and distribution of phages which infect a marine bacterium isolated from Tampa Bay (Florida. USA), tentatively identified (Microbial ID, Inc., Newark, Delaware, USA) as Vibrio parahaernolyticus. Using this host, we have isolated over 60 phages from the Gulf of Mexico, Tampa Bay, Florida Keys, and Oahu, Hawaii (USA). These isolates are all Myoviridae, with head sizes ranging from 50 i 0.0 to 65 2 4.2 nm and tail lengths of 60 * 3 6 to 100 i 5.0 nm. The type phage (Q16 from Tampa Bay) has a double-stranded DNA genome of 51 to 58 kb. A 1.5 k b EcoRl fragment of this genome has been cloned and used as a gene probe. All of the DNA from the phage isolates hybridized to this probe under stringent conditions, but not to DNA from other marine vibriophages and bacteriophages, suggesting genetic relatedness. Agarose gel electrophoresis of EcoRI digests of the DNAs, followed by Southern transfer and probing with the 1.5 kb gene probe, yielded 6 groups based upon banding patterns. These groups were not segregated geographically within the Florida isolates; however, all of the Hawaiian phages had a common restriction pattern. These data indicate that populations of genetically related phages are widely distnbuted over large geographic distances In the oceans.
Effects of deoxyadenosine on ribonucleotide reductase in adenosine deaminase‐deficient lymphocytes (1990)

To explore the relationship between ribonucleotide reductase and immunodysfunction in adenosine deaminase deficiency, the effects of deoxyadenosine on ribonucleotide reductase in ADA-deficient lymphocytes was investigated. An assay system for ribonucleotide reductase in intact permeabilized lymphocytes was developed to approximate physiological conditions. The activity of cytidine diphosphate (CDP) reductase in resting but not in proliferating lymphocytes in culture was inhibited by 1 to 10 mumol/L deoxyadenosine. The resting cells were protected from the toxicity of 1 mumol/L deoxyadenosine by 5 mmol/L nicotinamide or 30 mumol/L deoxycytidine and from that of 10 mumol/L deoxyadenosine by 30 mumol/L deoxycytidine. These findings suggest that depletion of nicotinamide adenine dinucleotide might be the principal cause of death in resting lymphocytes with ADA deficiency. It is concluded that the mechanism of deoxyadenosine toxicity on non-replicating lymphocytes, which may not be mediated by ribonucleotide reductase inhibition, is closely related to the mechanism of immunodysfunction in patients with ADA deficiency.
Molecular Design and Synthesis of Dicarbazolophane-Based Centrosymmetric Through-Space Donors for Solution-Processed Thermally Activated Delayed Fluorescence OLEDs (2021)

Conjugation-extended carbazolophane donors, dicarbazolophanes (<b>DCzp</b>), were designed and synthesized using a multifold stepwise Pd-catalyzed Buchwald-Hartwig amination/ring cyclization process. Furthermore, elaboration of the <b>DCzp</b> core is possible with the introduction of pendant carbazole derivative groups. This provides a way to tune the optoelectronic properties of the thermally activated delayed fluorescence (TADF) compounds <b>DCzpTRZtBu</b>, <b>dtBuCzDCzpTRZtBu</b>, and <b>dMeOCzDCzpTRZtBu</b>. Solution-processed organic light-emitting diodes (OLEDs) were fabricated and achieved a maximum external quantum efficiency (EQE<sub>max</sub>) of 8.2% and an EQE of 7.9% at 100 cd/m<sup>2</sup>.
Development of intelligent robot system realizing human skill - realization of ball lifting task using a mobile robot with monocular vision system (2006)

This paper presents a development of robot system that realizes ball lifting task. The ball lifting is considered as a basic practice in the ball sports such as tennis or soccer. Through this task by the robot, we intend to make clear the process of learning skill to realize the basic task by human. We examine the performance of robot system and demonstrate that the robot enables to perform this task in spite of many difficulties. Our purpose is to develop the intelligent robot system that realizes human skill and we build the basic but significant robot system as a first step
Effect On Vortex Induced Vibrations From RadialWater Jets Along A Circular Cylinder (2001)

Most of the latest years' research on vortex induced vibrations (VIV) of circular cylinders in water has been motivated by the offshore industry's need for reliable predictions of the behaviour of deepwater risers and free span pipelines subjected to ocean current. An obvious approach to solve VIV problems is to introduce suppression devices such as helical strakes or fearings. Such devices may influence the vortex shedding process in two ways: 1) 2-dimensional (2-D) effects will influence the local forces on the cross section and damping by altering the separation point as well as creating a general disturbance to the flow. 2) 3-D effects include changes in correlation of the vortex shedding process along the span of the cylinder. It is well known that vortex shedding on a long cylinder will lead to significant vibration amplitudes only if the shedding process along the cylinder is correlated, and that the vibration itself will control this correlation. There is hence a positive feedback from oscillation amplitudes to correlation that under ideal conditions will amplify the oscillation amplitude until a maximum value slightly above one cylinder diameter is reached. The present paper presents a novel approach for VIV suppression based on radial water jets from a prescribed pattern of circular openings in the cylinder wall. This flow will introduce a disturbance that is expected to yield reduced VIV amplitudes. Results will be presented from experiments in a towing tank testing a spring-supported cylinder with a helical pattern of radial water jets. The volume flow rate and reduced velocity have been varied in the tests. Oscillation amplitudes, frequencies, added mass and lift and drag force coefficients are presented and compared to results with a cylinder without any water blowing.
Supplementary Table 1 from Genetic Profiling Identifies Two Classes of Soft-Tissue Leiomyosarcomas with Distinct Clinical Characteristics (2023)

&lt;p&gt;PDF file - 61K, Clinical characteristics of the molecular cohort (N=73)&lt;/p&gt;