gebhart/patrepeval huggingface dataset:
Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): I. As2O3 exerts dose-dependent dual effects on APL cells. (1997)

Recent clinical studies in China showed that As2O3 is an effective and relatively safe drug in the treatment of acute promyelocytic leukemia (APL). We found previously that As2O3 can trigger apoptosis of APL cell line NB4 cells, which is associated with downregulation of bcl-2 gene expression and modulation of PML-RAR alpha chimeric protein. To further understand the mechanisms of this alternative therapy for APL, we investigated in this report the effects of a wide range of concentrations of As2O2 on cultured primary APL cells, all-trans retinoic acid (ATRA)-susceptible (NB4 cells) and ATRA-resistant (MR2 subclone) APL cell lines. The results indicated that As2O3 had dose-dependent dual effects on APL cells: inducing preferentially apoptosis at relatively high concentrations (0.5 to 2 micromol/L) and inducing partial differentiation at low concentrations (0.1 to 0.5 micromol/L). The rapid modulation and degradation of PML-RAR alpha proteins, which was induced by As2O3 at 0.1 to 2 micromol/L, could contribute to these two effects. Bone marrow and peripheral blood examination showed that myelocyte-like cells, probably as a result of partial in vivo differentiation, and degenerative cells increased after 2 to 3 weeks of continuous in vivo As2O3 treatment when leukemic promyelocytes decreased. In conclusion, combination of induction of apoptosis and partial differention could be the main cellular mechanisms of As2O3 in the treatment of APL, and PML-RAR alpha could play an important role in determining the specific effects of As2O3 on APL cells.
Dipeptidyl Peptidase IV Inhibition Enhances the Intestinotrophic Effect of Glucagon-Like Peptide-2 in Rats and Mice (2000)

Glucagon-like peptide-2 (GLP-2) induces intestinal growth in mice; but in normal rats, it seems less potent, possibly because of degradation of GLP-2 by the enzyme dipeptidyl peptidase IV (DPP-IV). The purpose of this study was to investigate the survival and effect of GLP-2 in rats and mice after sc injection of GLP-2 with or without the specific DPP-IV inhibitor, valine-pyrrolidide (VP). Rats were injected sc with 40 μg GLP-2 or 40 μg GLP-2+15 mg VP. Plasma was collected at different time points and analyzed, by RIA, for intact GLP-2. Rats were treated for 14 days with: saline; 15 mg VP; 40 μg GLP-2, 40 μg GLP-2+15 mg VP; 40 μg GLP-2 (3–33). Mice were treated for 10 days with: saline; 5 μg GLP-2; 5 μg GLP-2+1.5 mg VP; 25 μg GLP-2; 25 μg GLP-2 3–33). In both cases, body weight, intestinal weight, length, and morphometric data were measured. After sc injection, the plasma concentration of GLP-2 reached a maximum after 15 min, and elevated concentrations persisted for 4–8 h. With VP, the concentration of intact GLP-2 was about 2-fold higher for at least the initial 60 min. Rats treated with GLP-2+VP had increased (P < 0.01) small-bowel weight (4.68 ± 0.11%, relative to body weight), compared with the two control groups,[ 3.01 ± 0.06% (VP) and 2.94 ± 0.07% (NaCl)] and GLP-2 alone (3.52 ± 0.10%). In mice, the growth effect of 5 μg GLP-2+VP was comparable with that of 25 μg GLP-2. GLP-2 (3–33) had no effect in rats, but it had a weak effect on intestinal growth in mice. The extensive GLP-2 degradation in rats can be reduced by VP, and DPP-IV inhibition markedly enhances the intestinotrophic effect of GLP-2 in both rats and mice. We propose that DPP-IV inhibition may be considered to enhance the efficacy of GLP-2 as a therapeutic agent.
ChemInform Abstract: Asymmetric Mannich Synthesis of β‐Amino Acids with Two New Stereogenic Centers at the α and β Positions. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Chemotherapy-induced peripheral neurotoxicity (2015)

Precise definition of CIPN clinical features can be obtained by only using validated outcome measures. Therefore, a major aim of clinical research is to standardize CIPN assessment, also considering that healthcare providers and patients frequently have a different perception of CIPN severity. A second major aim in clinical research is to maintain a high level of attention to the possible neurotoxicity of drugs more recently introduced into clinical practice. Preclinical studies are of pivotal importance to identify druggable targets for pharmacological intervention in order to prevent or limit CIPN.
Elasticity modulus, shrinkage, and creep of high-strength concrete as adopted by AASHTO (2009)

This paper covers the experimental and theoretical components of National Cooperative Highway Research Program (NCHRP) research project Number 18-07, which is discussed in NCHRP Report 496. The components are related to modulus of elasticity, shrinkage, and creep of concrete. An experimental program was conducted at various bridge sites and at the University of Nebraska-Lincoln for specimens produced from raw materials and mixture proportions provided by 4 participating states: Nebraska, New Hampshire, Texas, and Washington. Previously reported measurements of material properties are also included. The experimental program was used to extend the pre-2005 AASHTO-LRFD specification prediction formulas to concrete with compressive strengths up to 15 ksi (104 MPa). For each material property, a summary of the experimental values is presented followed by a comparison with the values obtained from the pre-2005 AASHTO-LRFD specifications and the American Concrete Institute 209 committee report. The proposed formulas provide designers of prestressed concrete girders with more realistic estimates of long-term material properties, including effects of aggregate type and other significant factors. The use of these formulas with high-strength concrete (HSC) should result in more realistic camber predictions and lower prestress loss estimates. The background and recommendations for prediction of the modulus of elasticity, shrinkage, and creep of HSC are provided. To help with clarity, the notation and units employed in the pre-2005 AASHTO-LRFD specifications are adopted as much as possible. Stresses are expressed in units of ksi (MPa) rather than psi.
The Promyelocytic Leukemia Zinc Finger Transcription Factor Is Critical for Human Endometrial Stromal Cell Decidualization (2016)

Progesterone, via the progesterone receptor (PGR), is essential for endometrial stromal cell decidualization, a cellular transformation event in which stromal fibroblasts differentiate into decidual cells. Uterine decidualization supports embryo implantation and placentation as well as subsequent events, which together ensure a successful pregnancy. Accordingly, impaired decidualization results not only in implantation failure or early fetal miscarriage, but also may lead to potential adverse outcomes in all three pregnancy trimesters. Transcriptional reprogramming on a genome-wide scale underlies progesterone dependent decidualization of the human endometrial stromal cell (hESC). However, identification of the functionally essential signals encoded by these global transcriptional changes remains incomplete. Importantly, this knowledge-gap undercuts future efforts to improve diagnosis and treatment of implantation failure based on a dysfunctional endometrium. By integrating genome-wide datasets derived from decidualization of hESCs in culture, we reveal that the promyelocytic leukemia zinc finger (PLZF) transcription factor is rapidly induced by progesterone and that this induction is indispensable for progesterone-dependent decidualization. Chromatin immunoprecipitation followed by next generation sequencing (ChIP-Seq) identified at least ten progesterone response elements within the PLZF gene, indicating that PLZF may act as a direct target of PGR signaling. The spatiotemporal expression profile for PLZF in both the human and mouse endometrium offers further support for stromal PLZF as a mediator of the progesterone decidual signal. To identify functional targets of PLZF, integration of PLZF ChIP-Seq and RNA Pol II RNA-Seq datasets revealed that the early growth response 1 (EGR1) transcription factor is a PLZF target for which its level of expression must be reduced to enable progesterone dependent hESC decidualization. Apart from furnishing essential insights into the molecular mechanisms by which progesterone drives hESC decidualization, our findings provide a new conceptual framework that could lead to new avenues for diagnosis and/or treatment of adverse reproductive outcomes associated with a dysfunctional uterus.
Design of a Description Model for Location Information (DMLI) (2006)

This paper proposes design of a Description Model for Location Information (DMLI) to solve problems of different standards according to different location-data type from various positioning systems. DMLI does not redefine metadata of location data expressed by different types, but is a classification model that includes metadata including all the types. DMLI is composed of Facility, Place, and Service elements. DMLI can translate metadata element about existing location-data into its own metadata element using a dictionary that defines information between metadata elements related location. This study shows interoperability of DMLI between heterogeneous metadata, and adoptability of DMLI to various location-based applications for service such as searching, statistics, etc.
Recommendations in Product Personalization: An extended Example of Pipelined Filter Combination (2003)

Traditionally, customers spend most of their money for pre-configured off- the-shelf products. Simple product variations are offered, fine-tuning by the customer before the purchase is generally not intended. Why pay for functionality that is not wanted? Why spend money for products that are so rigid and do not satisfy a hundred percent? To remedy these issues, we discuss a possible solution based on recom- mendations. In our approach, traditional filtering techniques known from recommender systems guide the customer through a sophisticated product personalization process using pipelined filter combination. This process distinguishes between expert custom- ers and novices. An extended example proofs the rich capabilities of the proposed so- lution.
Glycosylation of proteins and microangiopathy. (1992)

Diabetic complications may result from chronic glycosylation of protein within cells and in the extracellular matrix. Prevention of glycosylation with aminoguanidine has forestalled complications in experimental diabetes.
Optimal Periodical Memory Allocation for Logic-in-Memory Image Processors (2006)

One major issue in designing image processors is to design a memory system that supports parallel access with a simple interconnection network. This paper presents a design methodology for a logic-in-memory architecture where each of memory modules is connected to its dedicated processing element (PE). An efficient memory allocation to minimize the number of memory modules and PEs under a time constraint is proposed based on regularity
Light sheet theta microscopy for rapid high-resolution imaging of large biological samples (2018)

The reported LSTM approach is a significant step for the rapid high-resolution quantitative mapping of the structure and function of very large biological systems, such as a clarified thick coronal slab of human brain and uniformly expanded tissues, and also for rapid volumetric calcium imaging of highly motile animals, such as Hydra, undergoing non-isomorphic body shape changes.
PROPAGATION ANALYSIS AND DEPLOYMENT OF A WIRELESS SENSOR NETWORK IN A FOREST (2010)

A complete study for the deployment of a wireless sensor network in a forest based on ZigBee is presented in this paper. First, due to the lack of propagation models for peer to peer networks in forests, propagation experiments were carried out to determine the propagation model.
Plasminogen activator inhibitor-1 is an independent prognostic factor of ovarian cancer and IMD-4482, a novel plasminogen activator inhibitor-1 inhibitor, inhibits ovarian cancer peritoneal dissemination (2017)

In the present study, the therapeutic potential of targeting plasminogen activator inhibitor-1 (PAI-1) in ovarian cancer was tested. Tissues samples from 154 cases of ovarian carcinoma were immunostained with anti-PAI-1 antibody, and the prognostic value was analyzed. Among the samples, 67% (104/154) showed strong PAI-1 expression; this was significantly associated with poor prognosis (progression-free survival: 20 vs. 31 months, P = 0.0033). In particular, among patients with stage II-IV serous adenocarcinoma, PAI-1 expression was an independent prognostic factor. The effect of a novel PAI-1 inhibitor, IMD-4482, on ovarian cancer cell lines was assessed and its therapeutic potential was examined using a xenograft mouse model of ovarian cancer. IMD-4482 inhibited <i>in vitro</i> cell adhesion to vitronectin in PAI-1-positive ovarian cancer cells, followed by the inhibition of extracellular signal-regulated kinase and focal adhesion kinase phosphorylation through dissociation of the PAI-urokinase receptor complex from integrin αVβ3. IMD-4482 caused G0/G1 cell arrest and inhibited the proliferation of PAI-1-positive ovarian cancer cells. In the xenograft model, IMD-4482 significantly inhibited peritoneal dissemination with the reduction of PAI-1 expression and the inhibition of focal adhesion kinase phosphorylation. Collectively, the functional inhibition of PAI-1 significantly inhibited ovarian cancer progression, and targeting PAI-1 may be a potential therapeutic strategy in ovarian cancer.
Charcot‐Marie‐Tooth Disease Type 4H Resulting from Compound Heterozygous Mutations inFGD4from Nonconsanguineous Korean Families (2015)

Charcot-Marie-Tooth disease type 4H (CMT4H) is an autosomal recessive demyelinating subtype of peripheral enuropathies caused by mutations in the FGD4 gene. Most CMT4H patients are in consanguineous Mediterranean families characterized by early onset and slow progression. We identified two CMT4H patients from a Korean CMT cohort, and performed a detailed genetic and clinical analysis in both cases. Both patients from nonconsanguineous families showed characteristic clinical manifestations of CMT4H including early onset, scoliosis, areflexia, and slow disease progression. Exome sequencing revealed novel compound heterozygous mutations in FGD4 as the underlying cause in both families (p.Arg468Gln and c.1512-2A>C in FC73, p.Met345Thr and c.2043+1G>A (p.Trp663Trpfs*30) in FC646). The missense mutations were located in highly conserved RhoGEF and PH domains which were predicted to be pathogenic in nature by in silico modeling. The CMT4H occurrence frequency was calculated to 0.7% in the Korean demyelinating CMT patients. This study is the first report of CMT4H in Korea. FGD4 assay could be considered as a means of molecular diagnosis for sporadic cases of demyelinating CMT with slow progression.
Covalent Targeting of Glutamate Cysteine Ligase to Inhibit Glutathione Synthesis (2023)

Abstract Dysregulated oxidative stress plays a major role in cancer pathogenesis and some types of cancer cells are particularly vulnerable to inhibiting cellular antioxidant capacity. Glutamate-cysteine ligase (GCL) is the first and rate-limiting step in the synthesis of the major cellular antioxidant glutathione (GSH). Developing a GCL inhibitor may be an attractive therapeutic strategy for certain cancer types that are particularly sensitive to oxidative stress. In this study, we reveal a cysteine-reactive covalent ligand EN25 that covalently targets an allosteric cysteine C114 on GCLM, the modifier subunit of GCL, leading to inhibition of GCL activity, lowering of cellular GSH levels, and impaired cell viability in ARID1A-deficient cancer cells that are particularly vulnerable to glutathione depletion, but not in ARID1A-positive cancer cells. Our studies uncover a novel potential ligandable site within GCLM that can be targeted to inhibit the GSH synthesis in cancer cells to target vulnerable cancer cell types.
Rapid screening of fruit juices and water supplies for contamination by 2,4‐d using an enzyme immunoassay (1994)

An enzyme‐linked immunosorbent assay (ELISA) for 2,4‐dichlorophenoxy acetic acid (2,4‐D) was developed using polyclonal antibodies raised in sheep, immunized with a derivative of 2,4‐D (2,4‐dichlorophenoxy acetyl‐2‐succinamyl hydrazine) conjugated to keyhole limpet haemocyanin. The mean percentage recovery of 2,4‐D from fortified water samples was 104% and ranged from 96 to 120% for fortified orange juice. The sensitivity of the assay without concentration of sample or sample clean‐up was 0.2 ng ml −1 for water and 50 ng ml −1 for orange juice. With dichloromethane extraction of 2,4‐D from orange juice, 1 ng ml −1 could be detected. 2,4,5‐T was the only herbicide investigated which cross‐reacted significantly with the 2,4‐D antisera. The ELISA also detected 2,4,5‐T in water, being sensitive to 0–66 ng ml −1. The ELISA is suitable for direct screening of water and fruit juice samples for 2,4‐D contamination.
Studies on Antihemorrhagic Principles in the Crude Drugs for Hemostatics. I. On Hemostatic Activities of the Crude Drugs for Hemostatics (1981)

Hemostatic activity of 12 drugs used in Chinese medicine for hemostatics was examined. Tajima's method on mouse was taken for the bioassay. It was found that the following seven drugs have a hemostatic activity. Denhichi, Panax pseudo-ginseng WALL. var. notoginseng (BURKILL) HOO & TSENG. Chiyu, Sanguisorba officinalis L. Kanrenso, Eclipta prostrata L. Seikon, Rubia cordifolia L. Sokuhakuyo, Biota orientalis (L.) ENDL. Renbo, Nulumbo nucifera GAERTN, Gusetsu, Nulumbo nucifera GAERTN.
Comparison of global responses to mild deficiency and excess copper levels in Arabidopsis seedlings (2013)

Copper is an essential micronutrient in higher plants, but it is toxic in excess. The fine adjustments required to fit copper nutritional demands for optimal growth are illustrated by the diverse, severe symptoms resulting from copper deficiency and excess. Here, a differential transcriptomic analysis was done between Arabidopsis thaliana plants suffering from mild copper deficiency and those with a slight copper excess. The effects on the genes encoding cuproproteins or copper homeostasis factors were included in a CuAt database, which was organised to collect additional information and connections to other databases. The categories overrepresented under copper deficiency and copper excess conditions are discussed. Different members of the categories overrepresented under copper deficiency conditions were both dependent and independent of the general copper deficiency transcriptional regulator SPL7. The putative regulatory elements in the promoter of the copper deficiency overrepresented genes, particularly of the iron superoxide dismutase gene FSD1, were also analysed. A 65 base pair promoter fragment, with at least three GTAC sequences, was found to be not only characteristic of them all, but was responsible for most of the FSD1 copper-dependent regulations. Moreover, a new molecular marker for the slight excess copper nutritional status is proposed. Taken together, these data further contribute to characterise copper nutritional responses in higher plants.
The extensional viscoelasticity of protein-coated interfaces (2011)

In shear or dilational testing, the interfacial rheology of a protein film adsorbed at a fluid–fluid interface is often determined by its response to dynamic deformation. In order to extract characterising parameters from the response data, a model must be assumed in order to fit the response, yet the assumption is difficult to validate due to the limited strain range accessible by most instruments. In this work, a modelling approach was developed to extract characterising parameters from stress–strain curves measured in a high-strain extensional mode of deformation. This mode of testing is insensitive to interfacial tension gradients, making it particularly useful for the study of interfacially adsorbed materials, such as proteins, where the relationship between interfacial tension and interfacial rheology is complex. A four-parameter version of the Generalised Maxwell Model (GMM) for three-dimensional viscoelastic materials successfully describes the response of a two-dimensional β-lactoglobulin interfacial film over a full linear strain range of 0–100%. The GMM asserts that viscoelastic relaxation occurs on multiple timescales, and in this case the two associated time constants give new insights into the nature of interfacial rheology, and its dependence on mass transfer with the bulk solution. In particular, washing out protein from the bulk solution has little effect on the initial response of the system, but a significant effect on the larger-strain response. Fitting a smaller strain range with a less parameterised model (e.g. 0–5% strain fitted with 2 parameters, or 0–20% fitted with 3 parameters) yielded a result that was reasonable up to the strain rate fitted, although the model did not predict well the response to greater strains. The major consequence is that unless a strain range large enough to allow significant influence of viscosity on observed response is tested, unreliable values of viscosity may be determined. Three other common proteins (lysozyme, bovine serum albumin and β-casein) were also tested. In each case, the films showed viscoelastic behaviour that could be well described by the 4-parameter GMM, allowing the viscous components for these protein films to be estimated more accurately than has been possible to date.
Determination of the time-dependence of Omega /sub NBS/ using the quantized Hall resistance (1989)

The quantum Hall effect is being used to monitor the US legal representation of the ohm, or as-maintained ohm, Omega /sub NBS/. Measurements have been made on a regular basis since August 1983. Individual transfers between the quantized Hall resistance R/sub H/ and the five 1- Omega resistors which comprise Omega /sub NBS/ can be made with a total of one standard deviation (1 sigma ) uncertainty of +or-0.014 p.p.m. This uncertainty is the root-sum-square of 32 individual components. The time-dependent expression for R/sub H/ in terms of Omega /sub NBS/ is: R/sub H/=25812.8(1+(1.842+or-0.012)*10/sup -6/=(0.0529+or-0.0040)(t-0.7785)*10/sup -6//year) Omega /sub NBS/, where t is measured in years from January 1, 1987. The value of Omega /sub NBS/ is, therefore, decreasing at the rate of (0.0529+or-0.0040) p.p.m./year.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
CON SACRIFICIOS Y CONSTANCIA, LOS ESCRITORES COLOMBIANOS HAN LOGRADO RECONOCIMIENTO (1994)

EL 14 DE JULIO INICIO LA III SEMANA CULTURAL COLOMBIANA, EN LA SALA MANUEL M. PONCE DEL PALACIO DE BELLAS ARTES, CON LA PARTICIPACION DE RECONOCIDOS ESCRITORES, QUIENES SE REFIRIERON A LA SITUACION DE LA CULTURA EN ESE PAIS LATINOAMERICANO, Y ESPECIFICAMENTE A LA LITERATURA Y LOS ESCRITORES.