gebhart/patrepeval huggingface dataset:
Pulmonary clearance of circulating endothelin-1 in dogs in vivo: exclusive role of ETBreceptors (1996)

The pulmonary circulation plays an important role in the removal of circulating endothelin-1 (ET-1). Plasma ET-1 levels are increased in pulmonary hypertensive states of various etiologies (e.g., idiopathic, heart failure, and congenital anomalies) in proportion to the severity of pulmonary hypertension. It is possible that reduced pulmonary clearance of this peptide contributes to the hyperendothelinemia of those pathologies. The ETA and ETB receptors are abundant in lung tissues: on the vascular endothelium, the ETB receptor is predominant and may contribute to ET-1 extraction through receptor-mediated endocytosis. We designed experiments to determine and quantify the importance of the ETA and ETB receptors in the pulmonary extraction of circulating ET-1 in anesthetized dogs. The single-pass cumulative tracer ET-1 extraction by the lung was measured with the indicator-dilution technique before and 5 min after intrapulmonary injection of the specific ETA antagonist BQ-123 (n = 5, 120-960 nmol) and the specific ETB antagonist BQ-788 (n = 6, 1,000 nmol). The inhibitors had no significant effect on pulmonary and systemic hemodynamics. Mean cumulative pulmonary ET-1 extraction was not modified by BQ-123 [control (C): 36 +/- 4%, antagonist (A): 34 +/- 6%] but was completely abolished by BQ-788 (C: 34 +/- 6%, A: 0 +/- 2%, P < 0.001). The pulmonary rate constant (K) for ET-1 removal was also unaffected by BQ-123 (C: 0.050 +/- 0.0085 s-1, A: 0.047 +/- 0.012 s-1) but significantly decreased and became close to zero after BQ-788 (C: 0.058 +/- 0.014 s-1, A: 0.009 +/- 0.007 s-1, P < 0.1). We conclude that the ETB receptor is completely and exclusively responsible for pulmonary ET-1 removal in vivo. Future studies are needed to show whether desensitization or downregulation of the ETB receptor may contribute to the increase in circulating ET-1 levels in conditions associated with pulmonary hypertension. This novel pulmonary endothelial cell function may play a protective role by modulating circulating ET-1 levels in the systemic circulation.
Real-time spectroscopic ellipsometry monitoring of Si1−xGex/Si epitaxial growth (1995)

Real-time spectroscopic ellipsometry has been used to monitor oxide desorption and Si1−xGex/Si multilayer growth. A database of dielectric function spectra at the growth temperature has been determined for x=0.07, 0.11, 0.15. Real-time data obtained during growth have been analyzed using spectral fitting techniques to determine composition at selected growth times, and by using time-dependent data to determine optical constants and growth rates. The pseudosubstrate approximation has been used to determine layer parameters from the growing surface and information on interface widths obtained.
Fault-Tolerant Training with On-Line Fault Detection for RRAM-Based Neural Computing Systems (2017)

An RRAM-based computing system (RCS) is an attractive hardware platform for implementing neural computing algorithms. Online training for RCS enables hardware-based learning for a given application and reduces the additional error caused by device parameter variations. However, a high occurrence rate of hard faults due to immature fabrication processes and limited write endurance restrict the applicability of on-line training for RCS. We propose a fault-tolerant on-line training method that alternates between a fault-detection phase and a fault-tolerant training phase. In the fault-detection phase, a quiescent-voltage comparison method is utilized. In the training phase, a threshold-training method and a re-mapping scheme is proposed. Our results show that, compared to neural computing without fault tolerance, the recognition accuracy for the Cifar-10 dataset improves from 37% to 83% when using low-endurance RRAM cells, and from 63% to 76% when using RRAM cells with high endurance but a high percentage of initial faults.
Multiturn flux transformers for rf SQUID magnetometers (1998)

This work showed experimentally how the planar multiturn input coil of a flux transformer could be integrated with a coplanar resonator while still permitting one to couple radio frequency (rf) signals to an rf SQUID. A new layout of a multiturn flux transformer with one pickup loop and two input coils, one single turn and one multiturn, has been fabricated on (001) substrates and evaluated. A planar double-hole washer SQUID was inductively coupled to the two separate input coils via a flip chip configuration. With this layout the best magnetometer showed magnetic field white noise of at 77 K in a magnetically shielded surrounding.
Contiguous genesyndromes duetodeletions inthedistal short arm ofthehumanX chromosome (1989)

ABSTRACT Mendelian inherited disorders due to dele-tions ofadjacentgenesonachromosomehavebeendescribedas contiguous genesyndromes. Shortstature, chondrodys-plasia punctata, mental retardation, steroid sulfatase defi- ciency, and Kallmann syndrome have been found as isolatedentities or associated in various combinations in 27 patientswith interstitial andterminaldeletionsinvolvingthedistalshortarm of the Xchromosome. The use of cDNA and genomicprobes from the Xp22-pter region allowed us to identify 12different deletion intervals andto confirm, andfurtherrefine,the chromosomal assignment of X-linked recessive chondro-dysplasia punctataandKallmannsyndromegenes. Aputative pseudoautosomal gene affecting height and an X-linked non- specific mentalretardationgenehavebeententativelyassignedto specific intervals. Thedeletion panel described is a usefultool for mapping new sequences and orienting chromosomewalks in the region.The distal part of the short arm of the Xchromosome-is a region of the human
Highly Concentrated Emulsions: Physicochemical Principles of Formulation (2002)

ABSTRACT This review deals with the preparation, stability, rheology and different applications of highly concentrated emulsions. These emulsions, which are known as high internal phase ratio emulsions (HIPRE), gel-emulsions, biliquid foams, etc., containing over 90% internal phase by volume, have a swollen micellar (L1 or L2) solution of nonionic or ionic surfactants as a continuous phase. These emulsions have the structure of biliquid foams and behave as gels since they present viscoelastic and plastic properties. The functional macroscopic properties of gel-emulsions are dependent on the structural parameters of the microemulsion continuous phase as well as of the interfacial properties (interfacial tension, bending modules, spontaneous curvature) of surfactant monolayers. The depletion interaction between emulsion droplets due to the non-compensated osmotic pressure of micelles is revealed as a main factor, along with surface forces, which determine the aggregative stability and the rheological properties of these emulsions. The effect of electrolyte and surfactant concentration, temperature, as well as other physicochemical parameters on the fiocculation threshold, stability, and yielding properties of highly concentrated emulsions is explained by the effect of these parameters on the critical micelle concentration (CMC) and the aggregation number of surfactants, and, consequently, on the depletion interaction. The thermodynamic theory of adhesion of fluid droplets in micellar solution and the suggested model of elasticity of gel-emulsions permit to explain the effect of mentioned physicochemical parameters on the elasticity modulus, the plastic strength and the linear deformation of these emulsions. A novel mechanism for the spontaneous formation of gel-emulsions by the phase inversion temperature (PIT) route is suggested, allows the selection of ternary systems able to yield these emulsions, and explains how the droplet size can be controlled during the PIT process. An original model for liquid film rupture is also suggested, and allows the prediction of the effect of structural parameters of micellar solutions and the interfacial properties of surfactant monolayers on the stability of gel-emulsions.
Transvenous Right Greater Splanchnic Nerve Ablation in Heart Failure and Preserved Ejection Fraction (2022)

In this open-label, single-arm feasibility study, right-sided GSN ablation was safe and improved mostly subjective clinical metrics in patients with HFpEF over 12 months. (Endovascular GSN Ablation in Subjects With HFpEF; NCT04287946).
Environmental Estrogenic Effects of Alkylphenol Ethoxylates (1996)

Alkylphenol ethoxylates (APEs) and related compounds recently have been reported to be estrogenic because it has been demonstrated in laboratory studies that they mimic the effects of estradiol both in vitro and in vivo. Chemicals referred to as "environmental estrogens" are suspected of causing health effects in both humans and wildlife through disruption of the endocrine system. In this review, the occurrence, environmental fate, and biological effects of APEs are presented. To provide understanding of the potential for endocrine disruption due to environmental estrogens, the physiology of estrogens in mammals and fish is also reviewed. The estrogenic potency of other environmental estrogens is compared to the potency of APE degradation products. The reproductive effects of estrogenic compounds are considered when evaluating the potential health effects of APEs. Given the reported environmental concentrations and bioconcentration factors of APE products, the potential for these compounds to produce estrogenic effects in the environment appears low. Although questions concerning the physiological effects of APEs and other environmental estrogens remain unanswered, there are indications that research is in progress that will lead to better understanding of the risks to humans and wildlife.
Modified nucleotides of tRNA(3Lys) modulate primer/template loop-loop interaction in the initiation complex of HIV-1 reverse transcription. (1993)

In all retroviruses, reverse transcription is primed by a tRNA whose 3' end 18 nucleotides are complementary to the so called viral primer binding site. Previous work showed that reverse transcription of HIV-1 RNA is initiated by tRNA(3Lys). Using a variety of chemical and enzymatic structural probes, we investigated the interactions between HIV-1 RNA and its natural primer tRNA(3Lys). In addition to the predictable contacts between the viral primer binding site and the 3' end of tRNA(3Lys), a specific interaction takes place between an A-rich loop located upstream of the primer binding site region and the anticodon loop of tRNA(3Lys). This AAAA/Umcm5s2UUU loop-loop interaction is not observed when the natural primer is replaced by an in vitro synthesized tRNA(3Lys) transcript. Furthermore, dethiolation of the modified nucleotide mcm5s2U at position 34 of tRNA(3Lys) strongly destabilizes this interaction. Sequence and structure comparisons indicate that the primer/template loop-loop interaction is conserved in all HIV-1 isolates, and possibly also in HIV-2 and SIV.
The laserwelding of aluminum tubes of alloy 6061 (1999)

This paper describes the development of a laser welding procedure for the fabrication of aluminum heat exchanger tubes and a biphasic heat exchanger both made of alloy 6061. In order to obtain a high quality weld the use of filler weld material (f.e. alloy 4047) had to be avoided.
Supplementary Material & figure legends from Oncogene-Induced Senescence Limits the Progression of Pancreatic Neoplasia through Production of Activin A (2023)

&lt;p&gt;Supplementary Material &amp; figure legends&lt;/p&gt;
From Wall street to main street: reaching out to small investors (2003)

We present an intelligent agent based portfolio management system, which can be used by the financial services industry to provide inexpensive Internet-based "self serve" offerings to small investors. This system is designed to assist investment banking firms, which offer funds of funds. Banker agents assist mutual fund managers in devising a global efficient frontier from the individual risk-return characteristics of each of the funds from which a portfolio can be constructed. Investor agents offer personalized advice to each individual investor regarding the choice of a portfolio. The various investor agents also learn from each other through "forums" hosted by the concerned financial services firm. Such a system requires minimal human intervention on both sides (the banker and the investor) thereby reducing costs without sacrificing service quality.
Histoire militaire des guerres puniques (2011)

À l’appui des données les plus récentes de l’histoire, Yann Le Bohec propose une relecture complète de l’affrontement qui opposa, de 264 à 146 avant J.-C., l’Empire romain, toute nouvelle puissance de la péninsule italienne à Carthage la subtile et mystérieuse civilisation de l’actuel Maghreb. Avec brio, il retrace la vie quotidienne et les motivations des combattants, les procédés tactiques mis en œuvre de part et d’autre ainsi que les stratégies multiples choisies par les généraux. À l’issue de ces guerres qui firent des centaines de milliers de morts et où s’illustrèrent Hamilcar, Hannibal et Scipion l’Africain, Rome domine le bassin occidental de la Méditerranée. Et Carthage fut détruite. Date de première édition : 1995.
Laser-based processing of polymer nanocomposites for chemical sensing applications (2001)

Pulsed laser deposition (PLD) has been used to fabricate polymer/carbon nanocomposite thin films for use in chemical sensors (chemiresistors). Ethylene vinyl acetate copolymer (EVA) films (undoped and 20% carbon by weight) were deposited using an ArF excimer laser (193 nm) at fluences between 150 and 300 mJ/cm2. The structure and morphology of the deposited films were characterized using Fourier transform infrared spectroscopy (FTIR), Raman scattering, and transmission and scanning electron microscopy (TEM). An analysis of the FTIR spectra indicates that a film deposited using an undoped EVA target is primarily polyethylene, suggesting that the acetate group is photochemically or photothermally removed from the starting material. Gas phase measurements of the laser-evaporated material using a quadrupole time of flight mass spectrometer confirm the production of the acetyl radical on the target surface. Analysis of TEM of films deposited using C-doped targets shows that the carbon black particles (initially 50 nm particles in 1 μm agglomerates) are broken down into particles that are ⩽50 nm in the deposited film. Incorporation of carbon into the target reduces the degree of photochemical damage of the starting material, as shown in the FTIR spectra of the deposited film. The sensitivity and response time of chemiresistors fabricated from 6 μm thick composite films on top of gold electrodes were measured using toluene vapor (548 ppm). The chemiresistors exhibited a reversible and fast (&amp;lt;1.3 s) response to the vapor. In comparison to data reported in the literature, chemiresistors fabricated from PLD films are significantly better than devices fabricated using a more conventional polymer film growth technique.
Vendor Malware: Detection Limits and Mitigation (2016)

Computing device vendors can introduce malware that is nearly impossible to detect with known methods, but microservice solutions can limit the negative impact. Malware contains instructions whose execution negatively impacts stakeholders, typically leading to unauthorized access and computation, data theft, loss of privacy, inability to inspect data, or prolonged downtime. A computing system's robustness to malware attacks strongly depends on the ability of the technical system and its stakeholders to either detect inactive malware before it executes or to detect active executing malware as soon as possible, before it causes serious damage. Many previous works discuss the general difficulty of detecting malware, but we focus on the ability of buyers and other legitimate stakeholders to detect malware inserted in computing devices by vendors and other insiders with access to the devices before they reach the buyers.
Production of SIV Vectors for Gene Delivery (2011)

INTRODUCTION The acquisition of vectors suitable for in vivo gene delivery has been a recurrent theme in gene therapy research. Several challenging hurdles must be overcome to reach this goal. First, the vectors must be prepared at high titers. Second, to avoid inactivation, the gene-transfer vectors should not be recognized by the host immune system. Third, the vectors should be able to replicate and to express a transgene in cells that are nonproliferating or slowly proliferating, a predominant situation in vivo. Lentiviral vectors derived from simian immunodeficiency virus (SIV) are similar to those derived from human immunodeficiency virus (HIV-1 or HIV-2) in that they can insert transgenes in nonproliferating cells. It is becoming clear, however, that SIV vectors perform better than HIV-1 vectors in simian cells, and thus may be a valid alternative to HIV-1-based vectors in the early phases of the clinical testing of lentiviral vectors in nonhuman primate models. This protocol describes the production of SIV vector particles and the assay used to measure transduction efficiency. Included also are methods for detecting replication-competent retroviruses (RCRs) and testing the putative mobilization of the green fluorescent protein (GFP)-containing SIV vector. The percentage of GFP-positive cells is determined by fluorescence-activated cell sorting (FACS). These safety assays make use of sMAGI target cells that are permissive to SIVmac251 replication and harbor a stably integrated lacZ transcription unit driven by the SIV/HIV tat -inducible HIV-1 long terminal repeat (LTR).
Carbon allocation and sugar status in individual cells of barley leaves affects expression of Sucrose: Fructan 6‐Fructosyltransferase gene (2001)

Summary Heterogeneity of function in plant tissues requires precise regulation of metabolic systems controlling resource allocation at the level of single cells. Differential distribution of metabolites between epidermis, mesophyll and parenchymatous bundle sheath (PBS) cells has already been demonstrated in barley ( Hordeum vulgare L.) source leaves and partitioning of sugars in barley leaves has been proven to be highly cell‐type specific. Carbohydrate metabolism of barley leaves induced to accumulate sucrose and fructans was investigated further at the individual cell level, using single cell sampling and analysis techniques. A novel approach using reverse transcription followed by polymerase chain reaction (RT‐PCR) was used to analyse expression of the enzyme Sucrose: Fructan 6‐Fructosyltransferase (6‐SFT) in individual cells of barley leaves. Accumulation of sucrose and the synthesis of fructans were induced by reducing export of sugars from leaves (root cooling), by increasing photosynthesis (high photon fluence rates), or by supplying sugars exogenously. In all cases there was a positive qualitative correlation between the presence of 6‐SFT transcripts and accumulation of fructan and sucrose in both mesophyll and PBS cells.
GaN field emitter array diode with integrated anode (1998)

GaN field emission pyramids are grown by self-limiting, selective-area metalorganic chemical vapor deposition. The self-limitation provides the potential of high uniformity of the pyramids and the selective-area growth allows one to define regular arrays of GaN pyramids for field emitter arrays (FEAs). Fabrication of an integrated anode lowered the operating voltage of the FEAs by narrowing the anode-cathode distance compared to devices with an external anode. A maximum emission current of 0.15 μA/tip has been observed for voltages of 570 V with an emitter-anode separation of 2 μm.
Nickel(0)-catalyzed cross coupling of aryl O-carbamates and aryl triflates with Grignard reagents. Directed ortho metalation-aligned synthetic methods for polysubstituted aromatics via a 1,2-dipole equivalent (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNickel(0)-catalyzed cross coupling of aryl O-carbamates and aryl triflates with Grignard reagents. Directed ortho metalation-aligned synthetic methods for polysubstituted aromatics via a 1,2-dipole equivalentSaumitra Sengupta, Magda Leite, Delio Soares Raslan, Claude Quesnelle, and Victor SnieckusCite this: J. Org. Chem. 1992, 57, 15, 4066–4068Publication Date (Print):July 1, 1992Publication History Published online1 May 2002Published inissue 1 July 1992https://pubs.acs.org/doi/10.1021/jo00041a004https://doi.org/10.1021/jo00041a004research-articleACS PublicationsRequest reuse permissionsArticle Views2608Altmetric-Citations175LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Cell kinetic study on transposed pedicled segments of the ileum between the colonic loops in rats - Analysis of promoting factors in DMH carcinogenicity on ileal mucosa. (1986)

ラットを用いたDMH発癌実験では発癌しない回腸でも結腸間に有茎移植することにより癌が好発する.この発癌性亢進の原因究明のためDMH非投与ラットの腸管上皮における細胞動態を解析した.その結果, 結腸間移植回腸では偽移植回腸にくらべmitotic indexが増加し, 細胞周期時間およびDNA合成期時間が軽度延長, growth fractionは軽度増加した.migration rateは1.4倍に増加し, transit timeは6.2時間短縮した.以上より回腸粘膜上皮は結腸間に移植されることにより細胞動態学的にhyperplasiaの所見を呈し, このことがDMH発癌に対し促進的に作用したと考えられた.
In-line particle size measurements for cement and other abrasive process environments (2002)

Cement manufacturers have historically been interested in implementing process control strategies to aid in production process QA/QC. Real-time measurement of Blaine number is of particular interest, since this is the primary measurement that cement producers use to gauge quality and strength of the final product. The three major hindrances to widespread application of in-line Blaine number measurement instrumentation in the past have been: (i) fragility of available instrumentation, (ii) inability of existing instrumentation to resolve changes in material properties, and (iii) lack of an effective means to directly measure Blaine number, or functional properties of the Blaine number. A recently introduced ensemble particle size and concentration sensor has successfully addressed these issues, enabling active process control in production environments. This optical sensor is described.
Bone Tunnel Diameter Measured with CT after Anterior Cruciate Ligament Reconstruction Using Double-Bundle Auto-Hamstring Tendons: Clinical Implications (2015)

Neither the diameter nor its change ratio during interval follow-up is correlated with stability or clinical scores.
Experience With the Fassier-Duval Telescopic Rod (2011)

In our experience the technique of using FD rods is demanding and associated with some intraoperative and postoperative pitfalls. We are happy to continue its use in OI patients when there is longitudinal stability and sufficient bone healing. However, in circumstances of insufficient stability and bone healing potential, further stabilization that can be achieved with an Ilizarov frame may be beneficial.