gebhart/patrepeval huggingface dataset:
Software Support for Heterogeneous Computing (2018)

Heterogeneous computing, materialized in the form of multiprocessor system-on-chips (MPSoC) comprising of various processing elements such as general-purpose cores with differing characteristics, GPUs, DSPs, non-programmable accelerators, and reconfigurable computing, are expected to dominate the current and the future consumer device landscape. The heterogeneity enables a computational kernel with specific requirements to be paired with the processing element(s) ideally suited to perform that computation, leading to substantially improved performance and energy-efficiency. While heterogeneous computing is an attractive proposition in theory, considerable software support at all levels is essential to fully realize its promises. The system software needs to orchestrate the different on-chip compute resources in a synergistic manner with minimal engagement from the application developers. We present compiler time and runtime techniques to unleash the full potential of heterogeneous multi-cores towards high-performance energy-efficient computing on consumer devices.
Microcapsules. Their Science and Technology. Part III. Industrial, Medical, and Pharmaceutical Applications. (2001)

Industrial, medical, and pharmaceutical applications of microcapsules are described. Pressure-sensitive copying paper is a typical example of their indutrial applications while sustained drug release devices are a representative example of their medical and pharmaceutical applications.
Contact Nonlinearity in Indenter–Foam Dampers (2022)

Abstract In this paper, the nonlinear response of indenter–foam dampers is characterized. Those dampers consist of indenters pressed on open-cell foams swollen with wetting liquids. Recently, the authors identified the dominant mechanism of damping in those dampers as poro-viscoelastic (PVE) relaxations as in articular cartilage, one of nature’s best solutions to vibration attenuation. Those previous works by the authors included dynamic mechanical analyses of the indenter–foam dampers under small vibrations, i.e., linear regime. The current study features the dynamic response of similar dampers under larger strains to investigate the nonlinear regime. In particular, the indenter–foam dampers tested in this paper consist of an open-cell polyurethane foam swollen with castor oil. Harmonic displacements are applied on the swollen and pre-compressed foam using a flat-ended cylindrical indenter. Measured forces and corresponding hysteresis (force–displacement) loops are then analyzed to quantify damping performance (via specific damping capacity) and nonlinearities (via harmonic ratio). The effects of strain and strain rates on the damping capacity and harmonic ratio are investigated experimentally. The dominant source of the nonlinearity is identified as peeling at the indenter–foam interface (and quantified via peeling index). A representative model consisting of a linear viscoelastic foam and rate-dependent adhesive interface (slider element with limiting adhesive strength) explains the observed trends in peeling and thus nonlinear dynamic response. Possible remedies to suppress those nonlinearities in future designs of indenter–foam dampers are also discussed.
Validation of the X-ray microtomography in the assessment of duodenal morphometry and surface area in celiac disease (2022)

Micro-CT showed excellent accuracy and reproducibility in the evaluation of mucosal morphometry and surface areas. The improved sensitivity for histological changes is a powerful tool for the diagnosis of celiac disease and for clinical and pharmacological studies.
States of Consciousness.Charles T. Tart, Ph.D. Lincoln, NE: Iuniverse.com, Inc. (2000). 305 Pages. (Original Work Published 1983). $30.95 (2004)

(2004). States of Consciousness. Charles T. Tart, Ph.D. Lincoln, NE: Iuniverse.com, Inc. (2000). 305 Pages. (Original Work Published 1983). $30.95. American Journal of Clinical Hypnosis: Vol. 46, No. 3, pp. 247-251.
Grading venous restrictive disease in patients with dural arteriovenous fistulas of the transverse/sigmoid sinus (1993)

Dural arteriovenous fistulas of the transverse/sigmoid sinus usually cause pulse-synchronous bruit but may present catastrophically. Current systems for classifying these vascular malformations do not consider obstruction of venous outflow, which increases the risk of intracranial hemorrhage due to retrograde flow via cortical veins. The authors have developed a grading system based on the severity of venous restrictive disease determined by superselective angiography. In a retrospective analysis of 25 patients with dural arteriovenous fistulas of the transverse/sigmoid sinus treated between 1988 and 1990, the grade of venous restrictive disease reflected the clinical presentation. Visual symptoms and central nervous system hemorrhage were more common in patients with cortical venous drainage and more severe distal venous occlusion (Grade 3: 31% and 31%, respectively; Grade 4: 67% and 100%, respectively) than in patients with cortical venous drainage and mild-to-moderate venous restrictive disease (Grade 2: 13% and 0%, respectively) or those without venous outflow (Grade 1: 0% and 0%, respectively). These preliminary results suggest that this grading system may be useful for predicting the risk of catastrophic clinical presentation and for guiding therapeutic decision-making in patients with dural arteriovenous fistulas of the transverse/sigmoid sinus. A prospective study of a larger number of patients is needed to validate the predictive value of this new grading system.
Whole brain-based computerized neuroimaging in ALS and other motor neuron disorders (2008)

Advanced neuroimaging applications to patients suffering from ALS and other motor neuron disorders (MND) have a high potential in terms of understanding the pathophysiology and visualizing the in vivo pathoanatomy of the diseases. In this context, particularly observer-independent computerized analyses of magnetic resonance imaging (MRI) data are of special interest since they overcome shortcomings of region-of-interest-based techniques. For three-dimensional structural T1-weighted MRI of the whole brain, voxel-based morphometry (VBM) has proven the most valuable approach to analyse regional volume alterations of the grey or white matter at group level. For the analysis of the white matter integrity with respect to tissue diffusivity and white matter connectivity including fibre tracking algorithms, diffusion tensor imaging (DTI) which can also be performed on a whole brain-basis is of the highest potential to date. Both VBM and DTI have been applied to various MND, in particular ALS, in multiple studies over recent years and have substantially broadened our knowledge about their in vivo pathoanatomy and mechanisms of neurodegeneration. Especially both the degree of damage to motor areas and the involvement of non-motor areas are of interest to be subjected to quantitative assessment, in order to establish quantitative surrogate markers for disease progression usable in clinical trials. Here, the technical state-of-the-art and the results of VBM and DTI studies in MND as the current state are reviewed, and future perspectives for further neuroimaging applications are highlighted.
Influence of Dietary Aluminum on Cytokine Production by Mitogen-Stimulated Spleen Cells from Swiss Webster Mice (1993)

Swiss Webster mice were exposed to excess dietary aluminum (Al) (1000 micrograms Al/g diet, Al as Al lactate) from conception to 6 months of age. Splenic lymphocytes (10(6) per culture) were incubated for 24 hrs with concanavalin A (5 micrograms/ml). Concentrations of interleukin-2, interferon-gamma and tumor necrosis factor-alpha, as measured in supernatants via ELISA with monoclonal antibodies, were depressed in spleen cells from aluminum treated mice relative to controls. Experiments using the fluorescence activated cell sorter demonstrated a shift in T-cell populations from treated mice with a deficiency of CD4+ cells. These findings suggest a deficit in immune effector cell function after long term in vivo aluminum exposure.
Consideraciones sobre la denominación de los electrodos para señales bioeléctricas externas (2012)

El creciente interes por la medida de senales bioelectricas mediante electrodos dispuestos fuera del cuerpo, ha suscitado propuestas que van desde la medicion sin contacto fisico hasta la integracion de electrodos en prendas de vestir y, como solucion intermedia, la disposicion de electrodos en ropa de cama o en asientos de diversos tipos. En muchos casos, esos electrodos no entran en contacto directo con la piel, por lo que a veces se designan como electrodos capacitivos, igual que los que no establecen ningun contacto fisico con el cuerpo. En este trabajo se propone un criterio para designar un electrodo como resistivo (conductor) o capacitivo, que considera el modelo equivalente para el electrodo y su repercusion en el diseno de los circuitos de entrada del sistema de adquisicion de senales. Segun este criterio, solo deberian considerarse como capacitivos aquellos electrodos cuya resistencia equivalente en un modelo formado por una resistencia en paralelo con una capacidad fuera demasiado grande para permitir la polarizacion de los amplificadores de entrada. Esto implica que la denominacion de los electrodos dependera de las caracteristicas del sistema de medida. Como ejemplo se presenta el IPG plantar en una bascula, que se puede obtener facilmente cuando los calcetines establecen un contacto directo con los electrodos de la bascula y el sistema de adquisicion esta disenado para electrodos resistivos.
Euclidean metrics for motion generation on SE(3) (2002)

Previous approaches to trajectory generation for rigid bodies have been either based on the so-called invariant screw motions or on ad hoc decompositions into rotations and translations. This paper formulates the trajectory generation problem in the framework of Lie groups and Riemannian geometry. The goal is to determine optimal curves joining given points with appropriate boundary conditions on the Euclidean group. Since this results in a two-point boundary value problem that has to be solved iteratively, a computationally efficient, analytical method that generates near-optimal trajectories is derived. The method consists of two steps. The first step involves generating the optimal trajectory in an ambient space, while the second step is used to project this trajectory onto the Euclidean group. The paper describes the method, its applications and its performance in terms of optimality and efficiency.
Adipocyte Differentiation: From Fibroblast to Endocrine Cell (2001)

Recent advances regarding the biology of adipose tissue have demonstrated that white adipose tissue (WAT) plays a central role in the regulation of energy balance and acts as a secretory/endocrine organ that mediates numerous physiological and pathological processes. Dysregulation of WAT mass causes obesity or lipoatrophy, two disorders associated with life-threatening pathologies, including cardiovascular diseases and diabetes. Alterations in WAT mass result from changes in adipocyte size and/or number. Change in adipocyte number is achieved through a complex interplay between proliferation and differentiation of preadipocytes. Adipocyte differentiation or adipogenesis is a highly controlled process that has been extensively studied for the last 25 years. In vitro preadipocyte culture systems that recapitulate most of the critical aspects of fat cell formation in vivo have allowed a meticulous dissection of the cellular and molecular events involved in the adipogenesis process. The adipogenic transcription factors peroxisome proliferator-activated receptor-gamma and CCAAT/enhancer binding protein-alpha play a key role in the complex transcriptional cascade that occurs during adipogenesis. Hormonal and nutritional signaling affects adipocyte differentiation in a positive or negative manner, and components involved in cell-cell or cell-matrix interactions are also pivotal in regulating the differentiation process. This knowledge provides a basis for understanding the physiological and pathophysiological mechanisms that underlie adipose tissue formation and for the development of novel and sound therapeutic approaches to treat obesity and its related diseases.
Swelling of ionic gels: quantitative performance of the Donnan theory (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSwelling of ionic gels: quantitative performance of the Donnan theoryJ. Ricka and Toyoichi TanakaCite this: Macromolecules 1984, 17, 12, 2916–2921Publication Date (Print):December 1, 1984Publication History Published online1 May 2002Published inissue 1 December 1984https://pubs.acs.org/doi/10.1021/ma00142a081https://doi.org/10.1021/ma00142a081research-articleACS PublicationsRequest reuse permissionsArticle Views3171Altmetric-Citations668LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Structural and Dynamic Properties of Incomplete Immunoglobulin-like Fold Domains (2012)

The immunoglobulin fold (Ig-fold) is a widespread structural motif that is detected in a variety of proteins involved in diversified biological processes. The Ig-fold contains 70-110 residues that are assembled in a characteristic sandwich-like structure formed by two facing β-sheets each made of antiparallel β-strands. A number of variations on this common theme have been detected and described (Ig-like fold). One of the most intriguing variants is characterized by the lack of a strand compared to the canonical motif (incomplete Ig-like fold). Interestingly, proteins exhibiting incomplete Ig-like fold have been shown to play an important role in mediating either protein-protein or domain-domain interactions. Protein-protein interactions mediated by incomplete Ig-like folds play a key structural role in the chaperone-usher pathway, a process that generates multi-protein assemblies essential for the adhesion of gram negative bacteria. Domains with incomplete Ig-like fold have also been discovered in the mechanism of action of adhesins belonging to the family of MSCRAMMs (microbial surface components recognizing adhesive matrix molecules). Recently, a stable incomplete Iglike fold has been detected in the peptidoglycan-binding extra-cellular portion of Staphylococcus aureus PrkC, an important Ser/Thr membrane kinase involved in bacterial growth and revival from latency. It is important to note that the occurrence of proteins with incomplete Ig-like fold is often related to cell adhesion and infectivity of bacterial pathological agents. We here report a survey of the structural data available on this peculiar structural motif highlighting analogies and differences of incomplete Ig-like fold involved in different processes. The dynamical behavior of these domains, investigated by molecular dynamics techniques, will be also commented.
Thoracic imaging (2010)

The various techniques encompassed in the term 'Thoracic Imaging' have had a dramatic effect on the practice of respiratory medicine over the last 25 years. One of many examples is the increased precision with which lung cancer can be preoperatively staged using CT and PET imaging. The increasing sophistication of thoracic imaging tests brings many benefits, but there are caveats. This review considers a selection of techniques and contains state-of-the-art commentaries by distinguished experts on current challenges and likely future developments.
Model-Based Simulations to Engineer Nanoporous Thin Films (2004)

Abstract : A model-based simulation (MBS) capability for tailoring the fabrication processes and the properties of wide band gap semiconductors thin films (TF) with engineered nanoscale porosity has been achieved in two ways: 1. By using molecular dynamics simulations (MDS) to relate a given set of deposition parameters to the resulting microstructure. 2. By developing a novel bending theory for a continuum body with microstructure.
Architecture features and evaluation of a variable-topology multiprocessor for real-time applications (2002)

This paper presents design and evaluation of a decentralized control mechanism of a phase reconfigurable multiprocessor architecture. The motivation stems from two facts. First, the delay caused by global synchronization and traffic congestions, using contemporary interconnection networks, is indeterministic. The indeterministic nature makes it very awkward to use the due systems for real-time applications. Second, many real-time applications require multi-phase computations which can only be implemented with a system that has a variable-topology capability. New technology is needed for an effective phase transition since existing phase transition methods involve too much overhead. A unique interconnection feature is used in the architecture. We design and implement an active crossbar communication processor which encodes a set of communication instructions. The new interconnection network approach provides an apt phase-reconfiguration method. The new method is distributed in nature and does not require a global control bus that is a time consuming feature as verified in many existing systems. Multiprocessor organization, computation model and languages features of this variable topology architecture are exploited. Conjugate-gradient algorithm for solving a linear system equations is used to provide evaluation and comparison.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Grating-based Fiber-to-chip Coupling Efficiency for Small Mode Field Diameter Fibers (2013)

We compute the fiber-to-chip coupling efficiency of grating couplers for fiber mode diameters ≤ 10µm. Modeling shows that high coupling efficiency (−1.5dB loss) can be achieved with smaller footprint for fibers with half the mode field diameter of the standard single mode fiber.
A Total Delivery System of Genetically Engineered Drugs or Cells for Diseased Vessels (1994)

The development of a percutaneous procedure using a catheterized system for diseased vessels has been increasingly in demand in conjunction with gene therapy using genetically engineered drugs (antisense) and cells. The authors' strategic concept realizes revascularization at narrowed, diseased sites and delivery of drugs or cells into the diseased tissues or targeted cells. An inflatable, drug-releasing double balloon is installed at the tip of a catheter. The outer balloon, fabricated with micropores (diameters of 20 and 30 mm) by an excimer laser ablation technique, releases a viscous solution containing a photoreactive polymer and drug or cells on inflation of the inner balloon. A photoresponsive water-soluble polymer, molecularly designed for its ability to achieve prolonged local residency of antisense DNA at the tissue level and enhanced transmembrane transport at the cellular level, is premixed with antisense oligonucleotide drug. On light irradiation, the nonionic polymer is reversibly converted to a positively charged polymer that can be complexed with highly negatively charged antisense DNA (c-myb), which may enhance the transmembrane delivery of antisense. On cessation of irradiation, the complex slowly dissociates to function intracellularly as an antisense drug, resulting in inhibition of cell proliferation. Thus, our integrated, dual-function balloon system may contribute to mechanical dilatation gene therapies at diseased vessels.
Robust and Energy-Efficient Trajectory Tracking for Mobile Devices (2014)

Many mobile location-aware applications require the sampling of trajectory data accurately over an extended period of time. However, continuous trajectory tracking poses new challenges to the overall battery life of the device, and thus novel energy-efficient sensor management strategies are necessary for improving the lifetime of such applications. Additionally, such sensor management strategies are required to provide a high and application-adjustable level of robustness regardless of the user’s transportation mode. In this article, we extend and further analyze the sensor management strategies of the EnTracked <inline-formula><tex-math>$_{T}$</tex-math> </inline-formula> system that intelligently determines when to sample different on-device sensors (e.g., accelerometer, compass and GPS) for trajectory tracking. Specifically, we propose the concept of situational bounding to improve and parameterize the robustness of sensor management strategies for trajectory tracking. We demonstrate the effectiveness of our proposed approach by performing a series of emulation experiments on real world data sets collected from different modes of transportation (including walking, running, biking and commuting by car) on mobile devices from two different platforms. Thorough experimental analyses indicate that our system can save significant amounts of battery power compared to the state-of-the-art position tracking systems, while simultaneously maintaining robustness and accuracy bounds as required by diverse location-aware applications.
A Single Rainbow Trout Cobalamin-binding Protein Stands in for Three Human Binders (2012)

Cobalamin uptake and transport in mammals are mediated by three cobalamin-binding proteins: haptocorrin, intrinsic factor, and transcobalamin. The nature of cobalamin-binding proteins in lower vertebrates remains to be elucidated. The aim of this study was to characterize the cobalamin-binding proteins of the rainbow trout (Oncorhynchus mykiss) and to compare their properties with those of the three human cobalamin-binding proteins. High cobalamin-binding capacity was found in trout stomach (210 pmol/g), roe (400 pmol/g), roe fluid (390 nmol/liter), and plasma (2500 nmol/liter). In all cases, it appeared to be the same protein based on analysis of partial sequences and immunological responses. The trout cobalamin-binding protein was purified from roe fluid, sequenced, and further characterized. Like haptocorrin, the trout cobalamin-binding protein was stable at low pH and had a high binding affinity for the cobalamin analog cobinamide. Like haptocorrin and transcobalamin, the trout cobalamin-binding protein was present in plasma and recognized ligands with altered nucleotide moiety. Like intrinsic factors, the trout cobalamin-binding protein was present in the stomach and resisted degradation by trypsin and chymotrypsin. It also resembled intrinsic factor in the composition of conserved residues in the primary cobalamin-binding site in the C terminus. The trout cobalamin-binding protein was glycosylated and displayed spectral properties comparable with those of haptocorrin and intrinsic factor. In conclusion, only one soluble cobalamin-binding protein was identified in the rainbow trout, a protein that structurally behaves like an intermediate between the three human cobalamin-binding proteins.