gebhart/patrepeval huggingface dataset:
Null Space-Based Precoding Scheme for Secondary Transmission in a Cognitive Radio MIMO System Using Second-Order Statistics (2009)

In this paper, we propose a null space-based precoding scheme for secondary transmission in a cognitive radio multiple-input multiple-output (CR-MIMO) network under the assumption that time-division-duplex is employed by the primary transmission. First, the secondary transmitter periodically senses the transmitted signals from the primary users and estimates the corresponding covariance matrix. Then, subspace techniques are utilized to estimate the noise subspace of this covariance matrix, and the dimension of the noise subspace is estimated using information theory criteria (AIC or MDL). Finally, the obtained null space is used as the precoding matrix for the secondary transmission, which effectively avoids the interference induced by the secondary transmission at the primary users. Moreover, the achievable capacity of the secondary MIMO channel by the proposed scheme is derived. Simulations are performed to show the efficacy of the proposed scheme.
Abstract 2574: A Novel Gain-of-function KCNJ2 Mutation Associated With Short QT Syndrome Impairs Inward Rectification of Kir 2.1 Currents (2009)

Background: Short QT syndrome is a recently recognized disorder associated with atrial fibrillation (AF) and sudden death due to ventricular arrhythmias. Mutations in several ion channel genes have...
Solution-adaptive grid procedure for the parabolized Navier-Stokes equations (1992)

A solution-adapt ive grid procedure based on an error equidistribution principle is developed and applied to a three-dimensional parabolized Navier-Stokes solver. The scheme redistributes grid points line by line in both crossflow directions, with grid point motion controlled by forces analogous to tensional and torsional spring forces. The tensional force is proportional to the error measure or a weighting function related to the error measure. The torsional force is used to control grid skewness relative to the upstream and cross-stream coordinate lines. Weighting functions are selected by first normalizing flowfield gradients and/or curvature of a number of dependent variables and then selecting the largest at each point. The hypersonic flow over a right-circular cone at three different yaw angles is studied to demonstrate the performance of the solution-adaptive grid procedure. Pitot pressure profiles and surface pressure computed using the solution-adaptive algorithm are compared with experimental results as well as with numerical results obtained using a fixed grid. Pitot pressure predictions using the adaptive grid algorithm show better agreement with experiment than those obtained using a fixed grid.
Free‐breathing 3D whole‐heart black‐blood imaging with motion sensitized driven equilibrium (2012)

MSDE-prep allows volumetric black-blood imaging of the heart.
Effects of dietary energy content and provision of β-adrenergic agonist on the production of feedlot lambs (2013)

Recent increases in mutton lamb prices have resulted in many lamb producers opting to finish more and more lambs on the farms in a feedlot system rather than marketing directly from the field. The aim of this trial was to determine the effect of dietary energy, as well as the inclusion of a β-adrenergic agonist, on the production of feedlot lambs. South African Mutton Merino lambs (108) of different sexes were weaned (± 36.4 kg) at ca. 120 days of age and were randomly divided into six experimental groups (18 lambs per group), which were adapted to each treatment. Lambs were housed in individual pens. The treatments consisted of three diets (diet 1: 11.3 MJ ME/kg food, diet: 2 12.0 MJ ME/kg food and diet 3: 12.7 MJ ME/kg) with either the inclusion or absence of a β-adrenergic agonist at 8.5 g/ton. The experimental design was a 3 x 2 x 2 factorial design with dietary energy level, the provision of a β-adrenergic agonist and sex as main factors. No interaction occurred between treatments and data are presented as the effect of dietary energy level and the inclusion of a stimulant on the intake, growth and feed conversion ratio (FCR). Neither the dietary energy content nor the β-adrenergic agonist had an effect on FCR. Neither one of the main factors had a significant effect on feed intake. The sex of the lambs had a significant effect on the average daily gain of the lambs with the ewes growing faster than the rams.
RF characterization of a tunable, high-gradient, X-band photoinjector (2000)

Highly accurate measurements of an X-band (8.548 GHz) radio frequency (RF) gun, designed to produce short (<1 ps), relativistic (5 MeV), low-emittance (<1 /spl pi/-mm/mrad, at 0.1 nC) electron bunches, have been performed at medium-power levels (1 kW, 6 /spl mu/s, 30 Hz). Balanced (within 3%), high-Q (4274), /spl pi/-mode excitation at critical coupling (S/sub 11/ < -80 dB) has been demonstrated by performing in situ phase measurements. A new tuning method to accurately adjust the coupling has been successfully implemented, which complements the independent tuning of the half and full cells, and the precise (-136 kHz//spl deg/C) temperature tuning of the gun. Finally, preliminary photoelectron results are also outlined.
Relationships between cholesterol homoeostasis and triacylglycerol-rich lipoprotein remnant metabolism in the metabolic syndrome (2003)

The dysmetabolic syndrome of insulin resistance and visceral obesity is characterized by elevated plasma concentration of triacylglycerol-rich lipoprotein (TRL) remnants that may be related to increased cardiovascular risk. Perturbed hepato-intestinal cholesterol metabolism may play a contributory role in this abnormality. We therefore investigated the association between plasma markers of cholesterol absorption and synthesis with TRL remnant metabolism in 35 men with the metabolic syndrome (MS). Plasma campesterol:cholesterol and lathosterol:cholesterol ratios were measured as estimates of cholesterol absorption and synthesis respectively. Remnant metabolism was assessed by measuring remnant-like particle-cholesterol (RLP-C), apolipoprotein (apo)B-48 and the fractional catabolic rate (FCR) of a labelled remnant-like emulsion. Compared with controls, subjects with the MS had significantly lower plasma campesterol:cholesterol ratio, but higher lathosterol:cholesterol ratio (P&lt;0.05). Plasma RLP-C and apoB-48 concentrations were also higher (P&lt;0.01) and the remnant-like emulsion FCR was lower (P&lt;0.05). The plasma campesterol:cholesterol ratio was inversely correlated (P&lt;0.05) with plasma triacylglycerols (r =-0.346), RLP-C (r =-0.443), apoB-48 (r =-0.427) and plasma lathosterol:cholesterol ratio (r =-0.366); the campesterol:cholesterol ratio was also positively correlated with the remnant-like emulsion FCR (r = 0.398, P&lt;0.05). In multiple regression analysis, the significant correlations between plasma campesterol:cholesterol ratio and plasma triacylglycerols, RLP-C, apoB-48 and FCR of the remnant-like emulsion were independent of age, dietary energy and plasma lathosterol. Our findings suggest that in subjects with the MS alterations in cholesterol absorption and synthesis may be closely linked with the kinetic defects in TRL metabolism.
Saturated fat stimulates obesity and hepatic steatosis and affects gut microbiota composition by an enhanced overflow of dietary fat to the distal intestine (2012)

We studied the effect of dietary fat type, varying in polyunsaturated-to-saturated fatty acid ratios (P/S), on development of metabolic syndrome. C57Bl/6J mice were fed purified high-fat diets (45E% fat) containing palm oil (HF-PO; P/S 0.4), olive oil (HF-OO; P/S 1.1), or safflower oil (HF-SO; P/S 7.8) for 8 wk. A low-fat palm oil diet (LF-PO; 10E% fat) was used as a reference. Additionally, we analyzed diet-induced changes in gut microbiota composition and mucosal gene expression. The HF-PO diet induced a higher body weight gain and liver triglyceride content compared with the HF-OO, HF-SO, or LF-PO diet. In the intestine, the HF-PO diet reduced microbial diversity and increased the Firmicutes-to-Bacteroidetes ratio. Although this fits a typical obesity profile, our data clearly indicate that an overflow of the HF-PO diet to the distal intestine, rather than obesity itself, is the main trigger for these gut microbiota changes. A HF-PO diet-induced elevation of lipid metabolism-related genes in the distal small intestine confirmed the overflow of palm oil to the distal intestine. Some of these lipid metabolism-related genes were previously already associated with the metabolic syndrome. In conclusion, our data indicate that saturated fat (HF-PO) has a more stimulatory effect on weight gain and hepatic lipid accumulation than unsaturated fat (HF-OO and HF-SO). The overflow of fat to the distal intestine on the HF-PO diet induced changes in gut microbiota composition and mucosal gene expression. We speculate that both are directly or indirectly contributive to the saturated fat-induced development of obesity and hepatic steatosis.
Abstract 3561: Associations of Carotid Plaque Composition with Prior Coronary and Peripheral Artery Events (2012)

Background: Patients with prior coronary (CAD) or peripheral artery (PAD) events have increased plaque burden in the carotid artery, which is subsequently found to indicate future risks in prospective studies. Carotid MRI is capable of measuring both plaque burden and components (calcification [CA], lipid rich necrotic core [LRNC], intraplaque hemorrhage [IPH]). We sought to determine if certain plaque components detected by MRI are associated with prior CAD and PAD events independently of traditional risk factors and plaque burden. Methods: Subjects with asymptomatic carotid stenosis by ultrasound were referred for a standardized multi-contrast carotid MRI. Plaque area and areas of CA, LRNC and IPH were traced on each cross-sectional slice, which were aggregated to determine plaque volume, presence and percent volumes of components for each subject. Prior CAD events were defined as prior acute coronary syndrome and/or coronary revascularization. Prior PAD events were defined as ABI&lt;0.90 and/or prior peripheral artery revascularization. Logistic regression analysis was used to evaluate the independent associations between plaque compositional variables and prior CAD or PAD events after adjustment for clinical variables and plaque volume. Results: A total of 159 subjects were scanned, of which 36 (22.6%) had prior CAD events, 34 (21.4%) had prior PAD events and 30 (18.9%) had both. The rest 59 (37.1%) subjects, free of both CAD and PAD events, were used as a reference group. All compositional variables were significantly associated with plaque volume. Subjects with prior CAD events (n=66) demonstrated a higher prevalence of IPH (31.8% vs. 13.6%, adjusted OR: 5.16, p=0.006) and larger percent volume of IPH (3.5% vs. 0.8%, adjusted OR: 1.21 per 1% change, p=0.017) compared to the reference group after adjustment for clinical variables and plaque volume. No independent associations were found between prior PAD events and carotid plaque components compared to the reference group. Conclusions: Subjects with prior CAD events appeared to have a higher prevalence of IPH and larger percent volume of IPH given a comparable plaque burden with those without prior events. Prospective studies are needed to evaluate if the composition of asymptomatic carotid plaques provides additional information for CAD risk stratification.
Effects of detergent on substrate binding and spin state of purified liver microsomal cytochrome P-450LM2 from phenobarbital-treated rabbits (1985)

Spectral changes accompanying the binding of the nonionic detergent n-octyl beta-D-glucopyranoside (n-octyl glucoside) to cytochrome P-450LM2 purified from liver microsomes of phenobarbital-treated rabbits have been compared to changes in catalytic activity obtained in a reconstituted system consisting of various levels of detergent, P-450LM2, and NADPH-cytochrome P-450 reductase. In the absence of substrate and reductase, addition of n-octyl glucoside to 2-3 mM resulted in a difference spectrum (detergent-bound minus detergent-free cytochrome) characterized by a small maximum at 390 nm and a minimum at 410 nm, suggestive of a slight stabilization of the high-spin (S = 5/2) state of the cytochrome. As the detergent concentration was increased to 4-8 mM (corresponding to maximal activity and pentameric or hexameric P-450), a new peak appeared at 427 nm while the minimum remained at 410 nm. Between 10 and 30 mM n-octyl glucoside (conditions which produced catalytically inactive and monomeric P-450) the minimum in the difference spectrum shifted to 390 nm and the maximum to 425 nm, characteristic of a shift in spin equilibrium toward low-spin (S = 1/2) cytochrome. At low and high detergent concentrations, substrate [d-benzphetamine with n-octyl glucoside or cyclohexane with the zwitterionic detergent 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate (CHAPS)] was bound to P-450LM2 with formation of high-spin P-450, although the increase in high-spin cytochrome was less at high detergent levels than at low. The affinity of P-450 for substrate decreased by 2-3-fold at high detergent.(ABSTRACT TRUNCATED AT 250 WORDS)
The KRASG12C Inhibitor MRTX849 Provides Insight toward Therapeutic Susceptibility of KRAS-Mutant Cancers in Mouse Models and Patients (2019)

Despite decades of research, efforts to directly target KRAS have been challenging. MRTX849 was identified as a potent, selective, and covalent KRAS<sup>G12C</sup> inhibitor that exhibits favorable drug-like properties, selectively modifies mutant cysteine 12 in GDP-bound KRAS<sup>G12C</sup>, and inhibits KRAS-dependent signaling. MRTX849 demonstrated pronounced tumor regression in 17 of 26 (65%) KRAS<sup>G12C</sup>-positive cell line- and patient-derived xenograft models from multiple tumor types, and objective responses have been observed in patients with KRAS<sup>G12C</sup>-positive lung and colon adenocarcinomas. Comprehensive pharmacodynamic and pharmacogenomic profiling in sensitive and partially resistant nonclinical models identified mechanisms implicated in limiting antitumor activity including KRAS nucleotide cycling and pathways that induce feedback reactivation and/or bypass KRAS dependence. These factors included activation of receptor tyrosine kinases (RTK), bypass of KRAS dependence, and genetic dysregulation of cell cycle. Combinations of MRTX849 with agents that target RTKs, mTOR, or cell cycle demonstrated enhanced response and marked tumor regression in several tumor models, including MRTX849-refractory models. SIGNIFICANCE: The discovery of MRTX849 provides a long-awaited opportunity to selectively target KRAS<sup>G12C</sup> in patients. The in-depth characterization of MRTX849 activity, elucidation of response and resistance mechanisms, and identification of effective combinations provide new insight toward KRAS dependence and the rational development of this class of agents.<i>See related commentary by Klempner and Hata, p. 20</i>.<i>This article is highlighted in the In This Issue feature, p. 1</i>.
New high-power source of directional electromagnetic radiation (2014)

A new source of electromagnetic radiation in a wide spectral range can be based on multiple contactless deflection of the beams of charged particles in a circular channel. The radiation with wavelengths ranging from submillimeter to radio ranges can be generated using nonrelativistic electrons. Directional radiation is obtained at relativistic energies. The IR, optical, and UV radiation can be generated. The X-ray and gamma-radiation can be obtained at relatively high energies. The new source is compared with the source of synchrotron radiation. The radiation intensity at energies of 1–2 GeV is relatively high, since strong currents are possible in the ring channel. The channeling and synchrotron emission are simultaneously obtained at relatively small (several tens of nanometers) internal diameters of the ring.
Carrier phase differential GPS/INS positioning for formation flight (1999)

A method for implementing and testing algorithms for combining differential carrier phase GPS and an INS system for formation flight of two NASA F-18 aircraft is presented. A computer architecture based on the PC-104 AT bus and commercial, off-the-shelf components is used for implementing the algorithms. Processing the carrier phase measurements using an INS with online calibration by a tightly coupled extended Kalman filter should provide relative position measurements to within 10 cm without the use of a stationary base station. Two methods are suggested for solving the integer ambiguity problem. The method of Farrell et al. uses hypothesis testing combined with least squares processing to determine the initial integer values. A second method uses the multiple model adaptive Kalman filter with improved convergence properties to estimate the integers. In order to test these algorithms and hardware, a hardware in the loop simulation using an IEC GPS Constellation Simulator will be constructed to validate accuracy claims.
Stress Measurement in Graphite/Epoxy Composites By X-Ray Diffraction from Fillers (1979)

The purpose of this work was to measure stresses in graphite/epoxy composites by diffracting X-rays from crystalline filler particles embedded in unidirectional laminates before curing. Particles used were Ag, Nb and CdO, having sharp diffraction peaks at large diffraction angles, θ. The diffraction peaks shift linearly with applied stress in the fiber direction and have stress sensitivities of (2.6, 3.9 and 1.9) X 10 -4 deg 2θ/MPa for Ag, Nb and CdO respectively. Elastic strains in filler particles measured by X-rays are proportional to the corresponding composite strains in agreement with the model of H. T. Hahn. Residual strains and stresses in filler particles were also obtained.
A forward looking automotive radar sensor (2002)

For intelligent cruise control (ICC) and forward looking collision warning systems (CWS) to be successful products they must provide robust performance in a complex roadway environment. Inconveniences caused by dropped tracks and nuisance alarms will not be tolerated by consumers, and would likely result in rejection of these new technologies in the marketplace. The authors report on a low-cost automotive millimeter wave (MMW) radar design which addresses shortcomings associated with previously reported ICC system implementations. The importance of the sensor's ability to identify and separately track all obstacles in the field of view is discussed. The applicability of the MMW FM-CW sensor implementation to collision warning systems is also discussed.
A Novel Approach of Removing Spurious DC Modes in Finite-Element Solution for Modeling Microwave Tubes (2010)

A convenient and efficient approach for removing the spurious dc modes in finite-element solutions for modeling microwave tubes is proposed. This method is based on higher-order hierarchical-basis functions and is able to deal with both standard and rotated periodic boundary conditions. The application of this approach results in a robust, accurate, and efficient eigensolver for slow-wave structures, which significantly reduces the required memory and computational time.
Microstructure and Chloride Diffusion Properties of Hardened Fly Ash Cement Paste with Three-dimensional Graphene (2022)

Abstract In this paper, the influence of three-dimensional graphene (3DG) on the microstructure and chloride diffusion properties of fly ash cement paste was investigated. 3DG accounting for 0.0–0.2% of cement mass was evenly dispersed in hardened cement paste containing fly ash by using ultrasonic and polycarboxylate superplasticizer. The microstructure of the cement paste was characterized by mercury intrusion test (MIP), X-ray diffraction (XRD), and scanning electron microscope (SEM). The results indicate that an appropriate amount of 3DG accelerates the secondary hydration of fly ash and provides a platform for the growth of cement hydration crystals. Moreover, the hydrated crystal fills the pores, reduces the harmful porosity, and refines the pore structure. The enhanced microstructure significantly improved mechanical properties and chloride diffusion resistance of hardened fly ash cement. With the addition of 0.1% 3DG, the compressive strength increased by 31.33%, and the chloride diffusion coefficient was reduced by 49.44%. The findings are beneficial to promote the generalized application of 3DG in cement in the marine environment.
Calibrated soil moisture data from Manaus, Brazil, August 2018 - December 2019 (2020)

This dataset contains calibrated soil moisture and rainfall data for ecohydrological studies in the Central Amazon (2.6099 ºS, 60.2093 ºW) taken at 30-min intervals. Soil moisture data was collected at depths of 0.025-, 0.05-, 0.15-, 0.30-, 0.50-,0.8-, 1.6-, 2.4-, 3.2-, 4.8-, 6.4-, 8.8-, and 14.20 m. Inconsistent data was removed during the QA/QC process. Further information including data collection methods are available in the associated publication, Negron-Juarez et al. 2020. Measurement and characterization of soil moisture dynamics in a Central Amazonian tropical forest (to be submitted).
Conference Report: 6<sup>th</sup> Clinical Trials on Alzheimer’s Disease (CTAD) Conference, Nov 14-16, 2013, The Westin San Diego Gaslamp Quarter Hotel, San Diego, CA, USA (2014)

6th Clinical Trials on Alzheimer's Disease (CTAD) Conference, Nov 14-16, 2013, The Westin San Diego Gaslamp Quarter Hotel, San Diego, CA, USA
Multi-site Analytical Evaluation of the Abbott ARCHITECT Tacrolimus Assay (2009)

The objective of this study was to evaluate the analytical performance of the Abbott ARCHITECT Tacrolimus immunoassay. Proficiency panels and specimens from a population of organ transplant recipients were analyzed in 6 clinical laboratories in Europe and the United States, and the results were compared with other methods. The ARCHITECT assay requires a whole blood specimen pretreatment step with methanol/zinc sulfate to precipitate protein and extract the drug, followed by a 30-minute immunoassay using anti-tacrolimus antibody-coated paramagnetic microparticles and an acridinium-tacrolimus tracer. The assay was free from hematocrit interference in the range 25%-55% and from interference by extremes of cholesterol, triglycerides, bilirubin, total protein, and uric acid. The total percent of coefficient of variations of the assay were 4.9%-7.6% at 3 ng/mL, 2.9%-4.6% at 8.6 ng/mL, and 3.1%-8.2% at 15.5 ng/mL. Limit of detection was < or =0.5 ng/mL and limit of quantification (LOQ) ranged from 0.69 to 1.07 ng/mL across the 6 sites (based on the upper 95% confidence interval concentrations). The 2007 European Consensus Conference on Tacrolimus Optimization recommended the use of assay methods with an LOQ around 1 ng/mL, based upon the need to measure trough tacrolimus blood concentrations precisely down to 3 ng/mL during low-dose tacrolimus regimens. Tacrolimus International Proficiency Testing Scheme samples were measured by the ARCHITECT immunoassay at 5 sites and showed an average bias of -0.28 to +0.85 ng/mL versus IMx Tacrolimus II immunoassay historical values and -0.21 to +0.68 ng/mL versus liquid chromatography/tandem mass spectrometry (LC-MSMS) Tacrolimus historical values. Method comparison studies were performed with the ARCHITECT Tacrolimus immunoassay on patient specimens with the following results: ARCHITECT Tacrolimus assay versus the Abbott IMx Tacrolimus II immunoassay (4 sites) yielded average biases between -0.94 and +0.26 ng/mL; ARCHITECT assay versus the Dade Dimension Tacrolimus immunoassay (2 sites) yielded average biases of -0.46 and +0.11 ng/mL; and ARCHITECT assay versus LC-MSMS methods at 2 sites yielded average biases of +0.51 and +1.63 ng/mL. Spearman correlation coefficients were >/=0.90 on all method comparisons. The ARCHITECT Tacrolimus assay is a semiautomated, robust, and highly sensitive immunoassay, representing an alternative approach for laboratories not equipped with LC-MSMS, and meets the 1 ng/mL recommendation of LOQ by the European Consensus Conference on Tacrolimus Optimization.