gebhart/patrepeval huggingface dataset:
ChemInform Abstract: SYNTH. UND NOREPINEPHRIN‐′DEPLETING′‐AKTIVITAET EINIGER ESTER DES METARAMINOLS (1972)

Abstract Aus dem über (Ia) und (Ib) erhaltenen und geschützten Aminoalkohol (IIa) erhält man über den O‐Benzoyl‐ester (IIb) das Amin (III) in sterisch einheitlicher Form.
REVIEW : Recent advances in developing web-servers for predicting protein attributes (2009)

Recent advance in large-scale genome se-quencing has generated a huge volume of pro-tein sequences. In order to timely utilize the in-formation hidden in these newly discovered sequences, it is highly desired to develop com- putational methods for efficiently identifying their various attributes because the information thus obtained will be very useful for both basic research and drug development. Particularly, it would be even more useful and welcome if a user-friendly web-server could be provided for each of these methods. In this minireview, a sy- stematic introduction is presented to highlight the development of these web-servers by our group during the last three years.
Is There a Difference in Graft Motion for Bone-Tendon-Bone and Hamstring Autograft ACL Reconstruction at 6 Weeks and 1 Year? (2016)

These study results may have significant implications for graft choice, rehabilitation strategies, and timing for return to sports.
Tomato Fruitworm Control, 1979 (1980)

Abstract Plots were direct seeded on Jun 1 at the North Carolina State University Central Crops Research Station, Clayton, NC. Plots consisted of a single row of tomatoes 20-ft long and 3.5 ft wide, separated within rows by 10—Ft of bare ground and between rows by one unplanted row. Overhead irrigation was supplied as needed. Treatments were replicated 4 times in a randomized complete block experimental design. Foliar sprays were applied using a tractor mounted, high pressure sprayer equipped with 3 hollow cone nozzles/row and delivering 60 gal/acre at 150 psi. Treatments were begun when ca 50% of the plants had set fruit. Applications were made weekly from Jul 26 to Aug 30. Sixty randomly selected ripe fruit/plot were harvested on Aug 31, one day after the last treatment, and 60 more/plot were harvested on Sep 6. All were examined for injury by H. zea.
Compressed Air Energy Storage (1978)

Compressed air energy storage (CAES) systems are being developed for peak load leveling applications by electric utilities. Energy is stored by compressing air in an underground reservoir; when power is required, the air is heated and expanded through a turbine-generator system. Several CAES plants are being designed, and construction of the first large-scale plant will be completed late in 1977. From the specifications of these systems, it is concluded that CAES systems appear to be economically favored over gas turbines and other near-term utility storage systems for a substantial range of costs of fuel and off-peak charging power.
Successful Catheter Ablation of Atrial Tachycardia Originating Near the Atrioventricular Node from the Noncoronary Sinus of Valsalva (2004)

This report describes a patient who underwent RF catheter ablation of atrial tachycardia. Two applications of RF energy near the His-bundle region transiently terminated the tachycardia. With detailed mapping at the aortic sinus of Valsalva using a retrograde transaortic approach, the earliest atrial activation was found in the noncoronary sinus of Valsalva. Complete elimination of the tachycardia was achieved with RF energy application from this site.
In vitro synthesis of IgE by human lymphocytes. II. Enhancement of the spontaneous IgE synthesis by IgE-binding factors secreted by RPMI 8866 lymphoblastoid B cells. (1984)

RPMI 8866 lymphoblastoid cells, known to express surface Fc epsilon R, were tested for their ability to regulate the in vitro synthesis of human IgE. Cell-free supernatants (CFS) of RPMI 8866 cells enhanced in a dose-dependent fashion the spontaneous IgE synthesis by B cells of allergic individuals. For maximum activity the CFS had to be added during the first 3 days of culture. CFS did not significantly alter the spontaneous synthesis of IgM or IgG, but they suppressed IgA synthesis both in B cell cultures and in pokeweed mitogen-stimulated peripheral blood mononuclear cells cultures. Cyclosporin A did not suppress either the spontaneous Ig production by B cells nor the IgE-potentiating activity of CFS. The enhancing activity of CFS was related to its content in IgE binding factors (IgE-BFs); these factors were detected by their ability to inhibit the rosetting of RPMI 8866 cells with IgE-coated erythrocytes (E-IgE). Both the IgE-BFs and the IgE-potentiating activity of the supernatants of RPMI 8866 cell cultures could be removed by absorption with IgE-Sepharose, from which they could subsequently be eluted with glycine-HCl buffer. IgE-BFs were identified as glycoproteins on the basis of their sensitivity to trypsin and to neuraminidase. By filtration of the RPMI 8866 cell supernatants through a Sephadex G75 column, IgE-binding activity was found to be associated with two fractions with molecular sizes in the range of 10,000-15,000 and 30,000-40,000. The IgA-suppressing activity of the RPMI 8866 culture filtrates could be absorbed with sIgA-Sepharose from which it was subsequently recovered by elution with glycine-HCl buffer. Most unexpectedly, sIgA-Sepharose also removed IgE-BFs and IgE-potentiating activity from the RPMI 8866 supernatants; both could be recovered by subsequent elution from sIgA-Sepharose with gycline-HCl buffer. These data are provisionally interpreted as indicating that the IgE-BFs secreted by RPMI 8866 cells had affinity for both IgE and sIgA and that they exerted a reciprocal effect on the in vitro synthesis of IgE and IgA.
Effects of Film Stress on the Chemical Mechanical Polishing Process (1999)

A theoretical model is constructed to simulate the pressure distribution arising from wafer curvature (film stress) during chemical mechanical polishing (CMP), based on theories of elastic contact stress. Results from oxide CMP experiments suggest that the wafer curvature results in a nonuniform polish rate distribution across the wafer, in agreement with the simulation based on the model. This stress‐dependent polish nonuniformity is attributed to the nonuniform pressure distribution across the wafer, induced by the wafer radius of curvature (film stress). Also, it was found that the magnitude of oxide film stress itself has little effect on removal rate. Oxides with tensile stress tend to have a weakened bond structure and enhanced chemical reactivity, both of which result in slightly higher removal rates. The reverse is true for oxides with compressive stress. Deviations from the model prediction may result from the stress induced by slurry flow, local variations in wafer shape and form, and pad surface properties. © 1999 The Electrochemical Society. All rights reserved.
Biological effects of four frequently used medicinal plants of Lamiaceae (2013)

Cancer is one of the leading causes of death characterized by uncontrolled growth and spread of cancer cells. There are several hundred thousands of new cases of cancer worldwide. Clinical oncology is still challenged by toxicity and side effects of multimodal therapy strategies in which it is associated with poor prognosis for patients. There is an urgent necessity to develop novel therapy strategies and to utilize preventive potential of natural compounds. As the majority of anticancer drugs are of natural origin, natural products represent a valuable source for the identification and development of novel treatment options and chemopreventive mechanisms for cancer. This review is focused on the summary of published knowledges on the antioxidant and potential chemopreventive effects of biologically active substances present in the extracts of four plants of the family Lamiaceae (sage, thyme, rosemary and lavander) in different animal and in vitro systems. It is assumed that the chemopreventive and chemotherapeutic potential of natural compounds is the result of a combined action of several mechanisms.
Therapeutic Potential of Small Molecule Inhibitor of Wnt Signaling in Acute Myelogenous Leukemia (2008)

Abstract Wnt signaling pathway controls various cellular and developmental processes. Deregulation of this pathway, in a wide range of human solid tumors, has been well established. However, less is known about its role in etiology of hematological cancers. Some characteristics of acute myelogenous leukemia (AML) cells such as inappropriate proliferation in the absence of normal growth signals and indefinite self-renewal similar to a stem cell are thought to be due to mutations in β-catenin, the hallmark of canonical Wnt pathway, and/or activation of Wnt pathway by fusion transcription factors. For therapeutic purposes, we have screened a peptidomimetic, β-turn library of small molecules for an inhibitor of Wnt pathway. Through massive chemical modifications the lead compound CWP231904 was selected. CWP231904 showed good inhibitory activity in the Reporter Gene Assay (RGA) on Topflash promoter in SW480 and HEK293 cells. Wnt target genes, survivin and c-myc were both down regulated upon CWP231904 treatments at the level of RNA and protein in MV4-11 and HL-60 AML cells. CWP231904 treatments of both cell lines induce cleavage of caspase-3, -8, and -9 by apoptotic signals. Propidium Iodide staining of these cells show dramatic increase in Apoptotic Index. CWP231904 treatment of MV4- 11 and HL-60 cells led to degradation of β-catenin in both cell lines. Proteasome inhibitor, MG132, prevented the CWP231904 induced degradation of β-catenin in MV4-11 cells. In order to unravel the mode of action of CWP231904, we utilized Wnt3a conditioned media (CM) or an overexpressed, Estradiol (ER) inducible Dishevelled plasmid (ER-DVL-2) to activate Wnt signaling in HEK293 cell line. Immunoblotting of HEK293 cells induced with ER and treated with CWP231904 showed a nuclear migration of the phosphorylated form of DVL-2 in treated cells. Thus, our data suggest that CWP231904 targets β-catenin degradation by relocating DVL-2 from cytoplasm where it makes puncta and inactivates GSK-3β containing destruction box complex into the nucleus. Moreover, CWP231904 treatment of HEK293 cells growing in Wnt3a CM lowered the inhibitory phosphorylation of GSK3-β on Serine9 which is induced upon Wnt activation, thereby keeping GSK3-β in its active form to phosphorylate β-catenin and signal it for degradation. CWP231904 significantly reduced tumor growth in MV4-11, HL-60 and MOLM-13 xenograft models, significantly increased the life span of the SCID mice, and decreased the number of CD45+ AML cells in the bone marrow after engraftment of MV4-11 cells via intravenous injection withoutdetectable toxicity. Together, these results suggest that CWP231904 has therapeutic potential for the treatment of AML disease by inhibiting Wnt signaling pathway through destabilization of β-catenin.
Neonatal pneumothorax (1976)

A simple method of providing under-water-seal drainage using readily available equipment is described. It enables adequate treatment of pneumothorax to be instituted with the minimum delay.
Modulation in spinal circuits and corticospinal connections following nerve stimulation and operant conditioning (2006)

Neural plasticity occurs throughout adult life. In healthy individuals, different spinal pathways are differently modulated during different daily activities. Drastic changes to nervous system activity and connections caused by injuries or diseases alter spinal reflexes, and this is often related to disturbed motor functions. In both health and disease, spinal reflexes are subject to substantial modifications. Plasticity in supraspinal descending connections is even more remarkable; corticospinal connectivity has been shown to be extremely plastic. In this session, we describe two approaches for possibly improving recovery after central nervous system (CNS) lesions. They are very different, but both involve repetitive nerve stimulation and CNS plasticity. The first approach is functional electrical stimulation (FES) of the common peroneal nerve, which has been used to treat foot drop in patients with CNS lesions. The second approach is operant conditioning of a spinal reflex. Spinal reflex operant conditioning studies in animal models have shown plastic changes in spinal cord neurons associated with this form of learning and improved locomotor function in incomplete spinal cord injured rats. Thus, reflex conditioning might be a robust approach to inducing plasticity at spinal and supraspinal levels. As a first step in establishing this approach and characterizing its effects in the human adult CNS, we are currently investigating the extent and time course of operant conditioning of the soleus H-reflex in healthy subjects. In results to date, all subjects (n=5) have changed reflex size in the correct direction to various degree (16-36%) over 2-3 months of conditioning, indicating possibility that H-reflex conditioning can occur in humans. At the same time, the substantial inter-subject variation in the time course and extent of conditioning suggest that additional data are needed to establish its principal features. We hope that studying modulation and modification o- f the CNS by different approaches will help us further understand the plasticity of the human adult nervous system.
Evaluation of surfactant‐aided degumming of vegetable oils by membrane technology (1999)

Abstract The first step in the process of vegetable oil refining is degumming, in which phospholipids and mucilaginous gums are removed that otherwise result in a low‐grade oil. A membrane process is remarkably simple yet potentially offers many advantages in degumming. Studies were conducted on surfactant‐aided membrane degumming with soybean and rapeseed oils in a magnetically stirred flat membrane batch cell with different types of microfiltration membranes. The reduction of phospholipids in soybean oil was in the range of 85.8–92.8% during the membrane process. The phosphorus content of membrane permeates of soybean oil was in the range of 20–58 mg/kg. Crude rapeseed oil contained higher amount of nonhydratable phospholipids and hence resulted in lower reduction in phospholipids, in the range of 66.4–83.2%. Addition of hydratable phospholipids could improve the efficiency of degumming in the membrane process without using any electrolyte, resulting in improvement of quality as well as quantity of the phospholipids.
Synthesis of multi-level self-checking logic (2002)

The problem of implementing self-checking combinational circuits is taken into account, with the initial requirement that self-checking capabilities be provided for otherwise optimized multilevel circuits produced by standard CAD tools, without affecting the circuit topology. The solution proposed involves a preliminary reduction of the number of inverters present in the circuit (it is assumed that inverters do not affect the circuit performances as measured by the optimizing CAD tools); then, "pseudo" inputs and outputs are added to the circuit itself in correspondence with the remaining inverters. The virtual circuit thus obtained, with the extended input-output set, is unate and thus grants a uni-directional error model in correspondence of single stuck-at faults. On such circuit a Berger coding policy can be applied, leading to a self-checking circuit covering all single stuck-at faults. Synthesis of the network providing the Berger checkbits is performed by use of Boolean relations.
A multidimensional typology of games (2003)

This paper builds on a general typology of textual com- munication (Aarseth 1997) and tries to establish a model for classifying the genre of “games in virtual environ- ments”— that is, games that take place in some kind of simulated world, as opposed to purely abstract games like poker or blackjack. The aim of the model is to identify the main differences between games in a rigorous, ana- lytical way, in order to come up with genres that are more specific and less ad hoc than those used by the industry and the popular gaming press. The model consists of a number of basic “dimensions”, such as Space, Perspective, Time, Teleology, etc, each of which has several variate values, (e.g. Teleology: finite (Half-Life) or infinite (EverQuest. Ideally, the multi- variate model can be used to predict games that do not yet exist, but could be invented by combining the exist- ing elements in new ways.
An Ultra-High Efficiency Multi-Beam IoT (2020)

Calabazas Creek Research, Inc. is developing a high efficiency, multi-beam Inductive Output Tube (IOT) for driving accelerators. The preliminary design analysis predicts an efficiency exceeding 80%, and final design and fabrication are in progress.
Numerical and Experimental Study of Bubble Dynamics in Contact with a Solid Surface (2018)

A complex numerical and experimental method is proposed for studying 3D dynamics of a bubble contacting with a surface in the presence of an acoustic field. The numerical approach is based on the boundary element method for potential flows, which is most efficient for solving the problems in a 3D formulation. The use of heterogeneous computer architectures consisting of central graphic processors and becoming more and more popular makes it possible to increase the scale of the problem and sufficiently reduce the calculation time. The mesh destabilization problems are solved using a spherical filter. To describe the contact line dynamics, a semi-empirical law of motion is used. The experimental method is based on high-speed recording and optical microscopy. An air bubble contacts with the inner surface of an experimental cell made from acrylic glass and filled with distilled water. The acoustic field in the cell generated by a disk-shaped acoustic radiator is measured using a hydrophone. The behavior of the bubble contacting with a hydrophillic surface is considered for the cases of a fixed or moving contact line. The shape and volume oscillations of the bubble are investigated. The results of numerical simulations agree qualitatively with the experimental data.
Inheritance of earliness, height, and leaf number in crosses of early maturing rapeseed (1986)

A dwarf early Brassica napus line (D-001), derived from crosses with Diplotaxis muralis, was crossed to two B. napus cultivars, 'Regent' and 'Pivot' to study the inheritance of earliness (days to bud, days to first flower, and days to maturity), height, and leaf number. Spaced plants of P 1 , P 2 , F 1 , F 2 , BC 1 , and BC 2 generations for both crosses were grown in a completely randomized design at two locations in Manitoba in 1984. Results of means analyses indicated that additive gene action predominated for all traits for both crosses and both locations. In addition, dominance gene action was found to influence days to first flower, days to maturity, and leaf number for the D-001 × 'Regent' cross and all traits for the D-001 × 'Pivot' cross. Nonallelic interactions were nonsignificant in all cases. Genotype × environment interactions were not significant for all traits except height. Variance analyses indicated a predominance of additive gene action. Broad sense heritabilities for phenological traits ranged from 55 to 90%, while narrow sense heritabilities ranged from 0 to 81%. For height, broad and narrow sense heritability estimates were equal and ranged from 51 to 84%. Heritability for leaf number ranged from 73 to 82% for broad sense and from 49 to 77% for narrow sense estimates. The predominance of additive gene action and the high heritabilities associated with these traits suggest that D-001 may be useful as a source of earliness in B. napus breeding programs. Key words: Brassica napus, earliness, inheritance, Diplotaxis muralis.
Effect of Pathway‐Interconnectors in SEB‐Induced Apoptosis Related Events in Human PBMCs (2015)

Staphylococcus enterotoxin B (SEB) is produced by the bacterium Staphylococcus aureus. SEB is the most common cause of food poisoning often accompanied with nausea, diarrhea, and intestinal cramping. The purpose of this study is to use human peripheral blood mononuclear cells (PBMCs) in order to better understand the apoptosis related events induced by SEB. This study is focused on inhibiting signaling pathways with the use of the inhibitor 4‐[5‐(4‐Fluorophenyl)‐2‐[4‐(methylsulfonyl)phenyl]‐1‐H‐imidazol‐4‐yl]pyridine (SB203580), followed by analyzing alterations to known expression patterns of genes associated with apoptosis. Here we attempt to better understand the type of pathway utilized by SEB by evaluating gene expression patterns using RT‐PCR. We will also investigate the Protein expression patterns of some genes through ELISA. We believe that our work will allow us to better understand the complex interactions of multiple signal transduction pathways as well as see the effects of inhibiting pathway interconnectors when induced by SEB.
Shaping the energy of port-Hamiltonian systems without solving PDE's (2015)

Equilibrium stabilisation of nonlinear systems via energy shaping is a well-established, robust, passivity-based controller design technique. Unfortunately, its application is often stymied by the need to solve partial differential equations. In this paper a new, fully constructive, procedure to shape the energy for a class of port-Hamiltonian systems that obviates the solution of partial differential equations is proposed. Proceeding from the well-known passive, power shaping output we propose a nonlinear static state-feedback that preserves passivity of this output but with a new storage function. This function contains some tuning gains used to ensure it is positive definite, hence a suitable Lyapunov function for the closed-loop. Connections with other standard passivity-based controllers are indicated and it is shown that the new controller design is applicable to two benchmark examples.
Production of xylooligosaccharides and monosaccharides from poplar by a two-step acetic acid and peroxide/acetic acid pretreatment (2019)

The AC and HPAC pretreatment of poplar represented an efficient strategy to produce XOS and fermentable sugars with high yields. This two-step pretreatment was a recyclable benign and advantageous scheme for biorefinery of the poplar into XOS and monosaccharides.