gebhart/patrepeval huggingface dataset:
Electrokinetics of salt-free concentrated suspensions including ion size effects (2013)

Analizamos la influencia de efectos de tamano ionico finito en la respuesta de una suspension concentrada salt-free de particulas esfericas a campos externos estaticos y oscilantes. Las suspensiones salt-free ideales estan compuestas unicamente por particulas coloidales cargadas y por los contraiones anadidos liberados por las particulas a la solucion y que contrarrestan su carga superficial. Consideramos tambien suspensiones salt-free realistas para acercarnos a las condiciones experimentales. Estas suspensiones realistas incluyen a los iones procedentes de la disociacion del agua y a los generados por contaminacion por CO2 atmosferico, ademas de los contraiones anadidos. Estudiamos la movilidad electroforetica estatica y dinamica de las particulas y la conductividad y la respuesta dielectrica de la suspension, asi como la doble capa electrica de equilibrio. Comparamos algunas de las predicciones teoricas con resultados experimentales preliminares. Encontramos que el tamano ionico finito modifica de forma significativa la region de condensacion ionica proxima a la superficie de la particula para cargas moderadas y altas. Este hecho produce un aumento de la movilidad electroforetica y de la relajacion de Maxwell-Wagner-O'Konski asociada con la capa de condensacion de contraiones, lo que resulta en un incremento de la movilidad dinamica para dichas frecuencias. Todos estos efectos aumentan con el tamano ionico y con la carga de la particula. Este trabajo muestra la importancia de incluir efectos de tamano ionico finito en cualquier extension que intente mejorar a los modelos electrocineticos estandar.
Synthesis of poly(ester carbonate) copolymers (1980)

Abstract The synthesis of poly(ester carbonate) copolymers based on bisphenol A, terephthalic acid, and phosgene is reviewed, and a new synthetic route is described leading to polymers which are different from those obtained by methods described in the literature. The most important features of the new method are quantitative incorporation of the dicarboxylic acid into the polymer and absence of undersirable side reactions. Synthesis of the random copolymer in which the dicarboxylic acid and carbonic acid groups are present in about equal molar amounts is discussed. Solution properties, effects of M̄ n and copolymer composition on T g , sequence length distribution, the effect of ester interchange reactions on molecular weight distribution, and effects of monofunctional chain termination on molecular weight of the final product are also discussed.
Hemodynamic Changes that Accompany the Pressor Response to Propranolol in Urethane Anesthetized Rats Subjected to &alpha;-Blockade (1990)

It has been shown that a paradoxical pressor response to a beta-blocker occurs in rats given an alpha-blocker. The dual-isotope microsphere technique was used to investigate the hemodynamic changes that accompany the pressor response to propranolol in phentolamine-treated, urethane-anesthetized rats. Rats were divided into four groups (n = 8 per group): group I received 10 min of saline infusion; group II received intravenous infusion of phentolamine (300 micrograms/kg/min) for 10 min; group III received intravenous injection of propranolol (100 micrograms/kg) after 20 min of phentolamine infusion, and group IV received intravenous injection of saline after 20 min of phentolamine infusion. In groups I and IV, saline did not cause any significant hemodynamic changes. In group II, phentolamine decreased the mean arterial pressure (MAP) and total peripheral resistance (TPR) by 34 +/- 3 mm Hg and 0.28 +/- 0.07 mm Hg/min/ml, respectively. Arterial conductances in the skeletal muscle and skin were increased to 157 and 165% of control values, respectively. Cardiac output and conductances in other tissues and organs were not significantly affected. In rats given phentolamine (group III), propranolol raised MAP (+40 +/- 2 mm Hg) by increasing TPR (+0.41 +/- 0.03 mm Hg/min/ml). Vascular conductances in the skeletal muscle, skin and kidneys were decreased to 38, 57 and 69% of control values, respectively. Conductances in other tissues and organs were not significantly affected. Our results show that propranolol raised MAP by increasing flow resistance, primarily via the reversal of the vasodilator effects of phentolamine in the muscle and skin.
Supplementary Figure 3 from A Small-Molecule c-Rel Inhibitor Reduces Alloactivation of T Cells without Compromising Antitumor Activity (2023)

&lt;p&gt;PDF file 128KB, Treg depletion from c-Rel deficient donor T-cells results in exacerbated GVHD&lt;/p&gt;
Millimetre wave signal generation using resonant tunneling diodes NLTL‐resonators (2007)

Abstract We present a novel approach of millimetre wave power generation using active microstructured nonlinear transmission line (NLTL) oscillators consisting of a periodic array of resonant tunneling diodes (RTDs). RTD‐NLTLs resonators have been measured to operate as distributed oscillators up to 50 GHz with power output up to −10 dBm. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 49: 2907–2909, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.22902
Magnetic and half-metallic properties of the full-Heusler alloys Co2TiX(X=Al,Ga;Si,Ge,Sn;Sb) (2005)

The electronic structure and magnetic properties of the full-Heusler alloys Co2TiX (X element from groups III, IV and V) were studied by first principle calculations. Previous calculations found Co2TiAl and Co2TiSn not to be half metallic. In this paper, however, it will be shown that the alloys with X=Al,Si,Ge,Sn are half metallic and ferromagnetic. The effect of atomic disorder in the Ti–Al sublattices reduces the half metallicity of the Co2TiAl Heusler alloy.
Giant Hysteresis of Single‐Molecule Magnets Adsorbed on a Nonmagnetic Insulator (2016)

TbPc2 single-molecule magnets adsorbed on a magnesium oxide tunnel barrier exhibit record magnetic remanence, record hysteresis opening, perfect out-of-plane alignment of the magnetic easy axes, and self-assembly into a well-ordered layer.
Narrow linewidth 2 µm GaSb-based semiconductor disk laser (2011)

In this contribution the authors report on the realization of tunable, narrow-linewidth GaSb-based OPSDLs emitting in the 2.0 - 2.35 μm wavelength range. The V-shaped laser cavity, schematically shown in the paper, is placed inside a stable, sealed and compact module housing in order to provide the necessary mechanical stability. The module is temperature stabilized to 20°C using a standard TEC element. For wavelength control and in order to enable single frequency emission, a quartz plate is inserted acting as a birefringent filter and the laser cavity is optimized for TEM <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">00</sub> mode emission. Using a high-finesse Fabry-Perot interferometer (FPI), stable single frequency operation was verified with an output power above 200 mW. Coarse wavelength tuning of up to 118 nm was achieved by rotating the quartz plate. By mounting the output coupling mirror onto a piezoelectric transducer (PZT), modehop-free fine-tuning of the laser wavelength of over 5 GHz was achieved, limited by the maximum travel of the PZT driven output coupling mirror.
Spezifische Infektionen (2008)

AuszugDie Tuberkulose ist die weltweit häufigste infektionsbedingte Todesursache und führt nur selten zur Aufnahme auf der Intensivstation. Hauptgründe für eine Intensivtherapie sind eine respiratorische Insuffizienz, Thoraxeingriffe, fortgeschrittene Tbc-Meningitis, tuberkulöse Perikarditis, Nebenwirkungen von Tuberkulostatika und eine tuberkuloseassoziierte Addison-Krise [].
Antineoplastic Agents. 535. Isolation and Structure of Plakorstatins 1 and 2 from the Indo-Pacific Sponge Plakortis nigra (2004)

Two new cancer cell growth inhibiting cyclic peroxides, plakorstatins 1 (1) and 2 (2), were isolated from the Indonesian marine sponge Plakortis nigra. The structures of plakorstatins 1 and 2 including relative configuration were elucidated on the basis of mass and 2D NMR spectroscopic interpretations. These are the first plakortides with an epoxy group in the side chain. Plakorstatin 2 was found to differ from plakorstatin 1 only in the configuration of the epoxide group. Both exhibited moderate cancer cell growth inhibition against the murine P388 lymphocytic leukemia cell line with ED(50) values of 1.1 and 0.91 microg/mL, respectively, for peroxides 1 and 2.
Experimental investigation of vibrational nonequilibrium in H2-O2 rocket engines (1996)

Spontaneous Raman spectroscopy was utilized in an experimental investigation of vibrational nonequilibrium in hydrogen-oxygen rocket engines. Oxygen temperatures were measured at subsonic, sonic, and supersonic portions of the nozzle flow. Rotational temperatures were determined from rotational Raman scattering. Both rotational and vibrational temperatures were determined from vibrational-rotational Raman spectra. Rotational temperatures from the two types of Raman scattering agree within the very large experimental error present. Vibrational temperatures are in agreement with rotational temperatures within the experimental error as well. Vibrational Raman spectroscopy is shown to be a valid means of estimating rotational temperatures within the rocket chamber and at low nozzle area ratios. Flowfield effects due to vibrational nonequilibrium are concluded to be minor. (Author)
Supplemental Figure 4-6 from Molecular Subtypes of Clear Cell Renal Cell Carcinoma Are Associated with Sunitinib Response in the Metastatic Setting (2023)

&lt;p&gt;Supplemental Figure 4-6. Figure S4: Characterisation of the ccRCC molecular subtypes: methylation status and Benporath polycomb signature; Figure S5: Cytogenetic characterization of the ccRCC molecular subtypes; Figure S6: Characterization of the ccRCC molecular subtypes: Myc methylation and (target) amplification&lt;/p&gt;
Supplementary Table from Targeting Plk1 Sensitizes Pancreatic Cancer to Immune Checkpoint Therapy (2023)

Supplementary Table from Targeting Plk1 Sensitizes Pancreatic Cancer to Immune Checkpoint Therapy
Manual curation and reannotation of the genomes of Clostridium difficile 630Δerm and C. difficile 630 (2017)

Based on the genomic analysis, several new metabolic features of C. difficile are proposed and could be supported by literature and subsequent experiments.
Role of framework mutations and antibody flexibility in the evolution of broadly neutralizing antibodies (2018)

Eliciting antibodies that are cross reactive with surface proteins of diverse strains of highly mutable pathogens (e.g., HIV, influenza) could be key for developing effective universal vaccines. Mutations in the framework regions of such broadly neutralizing antibodies (bnAbs) have been reported to play a role in determining their properties. We used molecular dynamics simulations and models of affinity maturation to study specific bnAbs against HIV. Our results suggest that there are different classes of evolutionary lineages for the bnAbs. If germline B cells that initiate affinity maturation have high affinity for the conserved residues of the targeted epitope, framework mutations increase antibody rigidity as affinity maturation progresses to evolve bnAbs. If the germline B cells exhibit weak/moderate affinity for conserved residues, an initial increase in flexibility via framework mutations may be required for the evolution of bnAbs. Subsequent mutations that increase rigidity result in highly potent bnAbs. Implications of our results for immunogen design are discussed.
III-V Nanowire Hetero-junction Tunnel FETs integrated on Si (2016)

In the last decade the power consumption of electronic devices has increased for both static and active components. Following the Dennard's scaling rule, as long as the transistor sizes are reduced then the supply voltage (VDD) can also be scaled in order to increase the area density and maintain or improve the performances. However, scaling VDD and thus shifting the threshold voltage (Vth) of 60mV in a metal-oxide semiconductor field-effect transistor (MOSFET) increases the OFF state current (Ioff ) by a factor of 10 in the ideal case. The reason for this is that the inverse subthreshold slope (SS) in an ideal MOSFET is limited by the thermionic emission of electrons over a potential barrier, which has an intrinsic physical limit of 60mV/decade. To overcome this limit, novel device concepts have been proposed and the tunnel field-effect transistor (TFET) is one of the most promising because it resembles a MOSFET and should enable to achieve sub-60mV/dec SS, low Ioff and small VDD. The aim of this thesis is to investigate the potential of TFETs by the fabrication and characterization of InAs/Si as p-channel and InAs/GaSb as n-channel device for a complementary TFET technology. III-V nanowires are grown via metal-organic chemical vapor deposition (MOCVD) and are integrated on Si(100) substrates using a novel technique called template-assisted selective epitaxy (TASE), which enables the fabrication of vertical and lateral III-V hetero-structure TFETs. Sub-40nm nanowire cross-section InAs/Si p-TFETs and InAs/GaSb n-TFETs in-plane on Si are demonstrated for the first time. The InAs/Si p-TFETs exhibit state-of-the art performances with an ON state current (Ion) of 4uA/um at VGS=VDS=-0.5V, ON/OFF ratio of 1x10E5 with SSavg of 70-80mV/dec at room temperature. The InAs/GaSb n-TFETs have an order of magnitude larger Ion but the SS is limited by the non-optimized gate-stack on InAs channel and by the depletion of the undoped GaSb source. Different operation regimes of TFETs are investigated by temperature-dependent measurements,Wentzel-Kramers-Brillouin (WKB) modeling and TCAD simulations, indicating that the switching region for InAs/Si is dominated by the presence of traps at the hetero-junction. The abruptness of the band-edges in InAs/GaSb is studied by the extraction of the conductance slope in fabricated p-n and p-i-n tunnel diodes.
Online Correction of Hard Errors and Soft Errors via One-Step Decodable OLS Codes for Emerging Last Level Caches (2019)

The number of marginal cells in static random-access memory (SRAM) increases as technology scales further. Spin transfer torque magnetic random-access memory (STT-MRAM) which is gaining popularity as a L3 cache alternative due to their small size, nonvolatility, high endurance, fast speed, scalability and low power consumption, also suffers from various stochastic and process variations causing both hard-errors and soft-errors in field. Orthogonal Latin Square (OLS) codes have been conventionally used in SRAMs for their low latency decoding. In this paper, an error-correcting scheme is proposed based on OLS codes which corrects both hard- errors and soft-errors simultaneously in a single step. The idea proposed is that in general a t-error correcting OLS code can be modified so that it can correct a certain number (t <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">s</sub> <; t) of soft-errors while tolerating a certain number of hard errors as well. This is achieved by storing the hard-error locations during the encoding procedure and masking the hard-error locations during the decoding procedure. A threshold voting based decoding is used instead of majority logic decoding. The proposed one-step decoding methodology is shown to have a small decoding latency. This enables high throughput for STT-MRAMs and SRAMs, even in the presence of errors, and increases their reliability. It is shown that compared to a naive increased strength code to address both hard errors and soft errors, the proposed codes achieve better hardware overhead as well as better data redundancy.
Immature mouse dendritic cells enter inflamed tissue, a process that requires E- and P-selectin, but not P-selectin glycoprotein ligand 1 (2002)

Inflammatory processes are associated with the rapid migration of dendritic cells (DCs) to regional lymph nodes and depletion of these potent antigen-presenting cells (APCs) from the inflamed tissue. This study examined whether sites of cutaneous inflammation can be repopulated with DCs from a pool of immature DCs circulating in the blood. In adoptive transfer experiments with ex vivo-generated radioactively labeled primary bone marrow-derived DCs injected into mice challenged by an allergic contact dermatitis reaction, immature DCs were actively recruited from the blood to sites of cutaneous inflammation, whereas mature DCs were not. Immature, but not mature, DCs were able to adhere specifically to immobilized recombinant E- and P-selectin under static as well as under flow conditions. P-selectin-dependent adhesion of immature DCs correlates with their higher level of expression of the carbohydrate epitope cutaneous lymphocyte-associated antigen (CLA) and is blocked by a novel inhibitory antibody against mouse P-selectin glycoprotein ligand 1 (PSGL-1). Surprisingly, however, emigration of immature DCs into inflamed skin is retained in the presence of this anti-PSGL-1 antibody and is also normal when immature DCs are generated from fucosyltransferase (Fuc-T) Fuc-TVII-deficient mice. By contrast, emigration of wild-type immature DCs is reduced by adhesion-blocking anti-E- and P-selectin antibodies, and immature DCs generated ex vivo from Fuc-TVII/Fuc-TIV double-deficient mice emigrate poorly. Thus, fucosylated ligands of the endothelial selectins, determined in part by Fuc-TIV, and independent of PSGL-1, are required for extravasation of DCs into sites of cutaneous inflammation.
Ecofriendly hydrogen production from abundant hydrogen sulfide using solar light-driven hierarchical nanostructured ZnIn2S4 photocatalyst (2011)

It is quite well-known that refineries are producing huge amount of H2S which has been used to produce sulphur and water using the well-known Claus process. This process is not an economically viable process, due to the high-cost chemical process and creates further acute environmental problems. Therefore, we have demonstrated the conversion of poisonous H2S into H2 using an ecofriendly phocatalysis process which is a green unconventional energy source. We have investigated ecofriendly nanostructured ZnIn2S4 photocatalyst to produce hydrogen from H2S using solar light. We also demonstrate the controlled synthesis of hierarchical nanostructured ZnIn2S4 using a facile hydrothermal method. The morphologies obtained have been greatly influenced by the presence of triethylamine (TEA) with various concentrations during the reaction. Surprisingly, a highly crystalline hexagonal layer structured ZnIn2S4 was obtained instead of cubic spinel. The hierarchical nanostructure, i.e. marigold flower-like morphology, was obtained without any surfactant. The thin and transparent petals self-assembled to form the unique nanostructured marigold flower. The highly crystalline puffy marigold flowers and nanoplates/nanostrips were obtained using TEA-assisted hydrothermal synthesis. Optical study shows the band gap in the range of 2.34–2.48 eV. Considering the band gap in the visible region, ZnIn2S4 is used as photocatalyst for hydrogen production from hydrogen sulphide under solar light which is hitherto unattempted. The constant photocatalytic activity of hydrogen evolution, i.e. 5287 μmol h−1, was obtained using such hierarchical nanostructured ZnIn2S4 under visible light irradiation. It is noteworthy that the H2 evolution rate obtained is much higher compared to earlier reported photocatalysts. Considering the significance of morphologies for photocatalytic application, the formation mechanism has also been furnished. The unique hierarchical nanostructured ZnIn2S4 ternary semiconductor having hexagonal layer will have potential applications in solar cells, LEDs, charge storage, electrochemical recording, thermoelectricity and other prospective electronic and optical devices.
Quantitative phosphoproteome analysis of a mouse liver cell line reveals specificity of phosphatase inhibitors (2008)

Abstract The liver is a central organ involved in many aspects of physiology and disease. Signaling properties of hepatocytes, the main liver cell type, are of special interest in metabolic diseases and in regeneration. For this reason we investigated the phosphoproteome of the mouse liver cell line Hepa1‐6 by stable isotope labeling by amino acids in cell culture (SILAC) and high resolution MS. Using stringent statistical evaluation criteria, we obtained 5433 phosphorylation sites on 1808 proteins. The phosphoproteome encompasses all major protein classes, including a large number of transcription factors. We compared control and phosphatase inhibitor treated cells by SILAC. This enabled ready identification of in vivo phosphorylation sites by sequencing the more abundant, inhibitor induced version of the peptide while still observing the endogenous version. We employed a mixture of pervanadate for blocking protein tyrosine phosphatases (PTPs) and calyculin A and deltamethrin for blocking the activities of serine/threonine phosphatases. Interestingly, these commonly used inhibitors in standard concentrations affected only 28% of the phosphopeptides by at least two‐fold. The unaffected sites may be substrates of phosphatases that are not efficiently inhibited, have slow kinetic or sites that are almost stoichiometric in normally growing cells. Finally, we devised a triple labeling strategy comprising control cells, stimulated cells, and phosphatase treated cells to derive an upper bound on phosphorylation occupancy.
Linguagem e ideologia: reflexões preliminares (2009)

Esta pesquisa tem como escopo principal fazer uma analise da ideologia predominante em quatro edicoes da Revista Boa Forma, dos anos de 2005,2010,1997 e 2007, especificamente, os titulos das reportagens principais de cada exemplar. Para tanto, priorizamos uma abordagem enunciativa/discursiva da linguagem, tendo como âncora as ideias-chave postuladas por Bakhtin, no que se refere a encarnacao material do signo linguistico enquanto objeto eminentemente ideologico.Logo, foi utilizado o metodo qualitativo, ja que o tema pesquisado demandou um estudo fundamentalmente interpretativo que nos levou a concluir que a superestrutura, representada pela midia, atraves da sua linguagem manipuladora institucionaliza um determinado padrao de beleza que deve ser mimetizado pelo seu real auditorio, a saber,as leitoras da Revista Boa Forma.