gebhart/patrepeval huggingface dataset:
Adaptive Mutation by Deletions in Small Mononucleotide Repeats (1994)

Adaptive reversion of a +1 frameshift mutation in Escherichia coli, which requires homologous recombination functions, is shown here to occur by -1 deletions in regions of small mononucleotide repeats. This pattern makes improbable recombinational mechanisms for adaptive mutation in which blocks of sequences are transferred into the mutating gene, and it supports mechanisms that use DNA polymerase errors. The pattern appears similar to that of mutations found in yeast cells and in hereditary colon cancer cells that are deficient in mismatch repair. These results suggest a recombinational mechanism for adaptive mutation that functions through polymerase errors that persist as a result of a deficiency in post-synthesis mismatch repair.
PSA as a marker of testosterone biological activity (2013)

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
Irradiated Type 304 SS bend test ductility (1980)

A series of tests were performed to determine the available bending deformation capability and ductility of preirradiated Type 304 stainless steel (SS) for core applications. This material was tested under conditions at which it exhibits less ductility than Type 316 SS or other stainless steels currently under considerations for core applications. Tensile testing of Type 304 SS with specimens from EBR-II ducts which were irradiated to fluences between 5 to 10 x 10/sup 22/ n/cm/sup 2/ (E > 0.1 MeV) revealed a significant reduction of uniform elongation (UE) and total elongation (TE), but smaller decreases in reduction of area (RA). These specimens fail with significant but very localized necking. The ductility of this material decreases with decreasing strain rate if the test temperature is above the irradiation temperature. A large reduction in ductility is caused by a change from a transgranular to an intergranular fracture mode.
Integrated, one-pot carbon capture and utilisation using porous ionic liquids (2021)

Porous ionic liquids combining alkylphosphonium halides with ZIF-8 absorb large amounts of carbon dioxide that can be catalytically coupled with epoxides to form cyclic carbonates. High activity and selectivity under mild reaction conditions points towards a new promising, high-performing, sustainable family of sorbents for simultaneous carbon capture and transformation.
On-Chip Biological and Chemical Sensing With Reversed Fano Lineshape Enabled by Embedded Microring Resonators (2014)

High- Q microresonators play an important role in developing fully integrated, highly sensitive, and cost-effective bio/chemical sensors. The Fano effect in doubly resonant physical systems may be used to improve sensing performance. In this paper, we show that coupled optical resonators (sometimes termed photonic molecules) in an embedded configuration can significantly enhance the sensitivity and limit of detection (LOD) of on-chip sensors by producing a reversed Fano effect. Improvement of one order in sensitivity, as compared to a sensor based on conventional Fano effect, can be achieved using embedded high- Q resonators on a CMOS-compatible platform. We estimate the LOD by taking into account thermal drift, optical losses (material absorption, scattering, substrate leakage and bending loss), laser intensity noise, linewidth and frequency jitter, and link and detector signal-to-noise ratio (SNR). The overall LOD is found to be as low as 3.24 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-8</sup> RIU. Moreover, in the proposed sensor based on embedded rings, intensity SNR is no longer the limiting factor of the LOD, which could be further lowered with better thermal control and laser frequency stability.
Do our chief executives have their finger on the pulse (2002)

How important is an accurate understanding of organisational culture, leadership, human resource capability and the external environment in effective organisational planning and strategising? Most would answer, "Critical."
Overcomplete MCTF for improved spatial scalability in 3D wavelet video compression (2005)

As of its open-loop structure and good decorrelation capability, motion-compensated temporal filtering (MCTF) provides a robust basis for highly-efficient scalable video coding. Combining MCTF with spatial wavelet decomposition and embedded quantization results in a 3D wavelet video compression system, providing temporal, spatial, and SNR scalability. Recent results indicate that the overall coding performance of these systems can be maximized if temporal filtering is performed in spatial domain (t+2D approach). However, as compared to non-scalable video coding, the performance of t+2D systems may not be satisfactory if spatial scalability needs to be provided. One important reason for this fact is the problem of spatial scalability of motion information. In this paper we present a conceptually new approach for t+2D-based video compression with spatially scalable motion information. We call our approach overcomplete MCTF since multiple spatial-domain temporal filtering operations are needed to generate the lower spatial scales of the temporal subbands. Specifically, the encoder performs MCTF-based generation of reference sequences for the coarser spatial scales. We find that the newly generated reference sequences are of satisfactory quality. Compared to the conventional t+2D system, our approach allows for optimization of the reconstruction quality at lower spatial scales while having reduced impact on the reconstruction quality at high spatial scales/bitrates.
Efficient Parallel Dwarf Data Cube Using MapReduce (2011)

In the data-intensive computing,this paper proposes an efficient parallel Dwarf data cube construction algorithm using MapReduce framework.The algorithm divides the traditional Dwarf cube into several independent sub-Dwarf cubes,and then achieves parallel building,querying and updating of Dwarf cube by using MapReduce framework.Finally,experiments show that the parallel Dwarf algorithm not only combines the parallelism and scalability of MapReduce framework,but also combines the high compression and the self-indexing of the data of Dwarf cube structure.The parallel Dwarf algorithm not only achieves the high compression ratio for data storage and provides the rapid construction and incremental update operation,but also overcomes the disadvantage that there is no index in MapReduce mechanisms,to achieve the fast query on the data cube.
European Society of Endodontology position statement: The restoration of root filled teeth (2021)

This position statement on the restoration of root filled teeth represents the consensus of an expert committee, convened by the European Society of Endodontology (ESE). Current clinical and scientific evidence, as well as the expertise of the committee, have been used to develop this statement. The aim is to provide clinicians with evidence-based principles for decision-making on the choice of restoration following the completion of root canal treatment. By discussing the evidence in relation to key topics regarding post-endodontic restoration, a series of clinical recommendations are made. The scientific basis of the recommendations made in this paper can be found in a recently published review article (Bhuva et al. 2021, International Endodontic Journal, https://doi.org/10.1111/iej.13438). It is the intention of the committee to update this statement as further evidence emerges.
A novel design of 4-bit distributed MEMS transmission line (DMTL) phase shifter using an RF shunt capacitive MEMS switch for phased array antenna (2014)

In this paper, coplanar waveguide (CPW) of dimension (0.2/1.6/0.2) mm has been used as the transmission line on which a ten number of Capacitive Shunt RF Mems Switches are periodically spaced in order to achieve appreciable phase shift. The dimensions of the transmission line may be designed to provide a transmission line of 50Ω characteristic impedance periodically. A 4-bit Distributed Mems transmission line (DMTL) phase shifter has been designed and provides the phase shifts of 900/3540/3360 depending on the combination of bits being used. The frequency of the complete designed is taken as 3-4 GHz of S-band and resonant frequency of around 3.55 GHz. A highly integrated complete structure has been designed on FR4-epoxy substrate having relative permittivity of 4.4 and has the area of 164.17 × 85.49 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> only. The designed and analysis is performed by using High Frequency Structural Simulator (HFSS version 13.0) software.
Moving the 'desktop' into the field (1994)

The electricty industry, as other utilities, is concerned with the management of large scale distribution networks. These networks have been developing for more than a century and the methods for operating them have changed over this time. For almost fifty years mobile communications have played an increasingly important role in the co-ordination of activities in the field. In more recent years, the industry has exploited IT with the result that a significant amount of mixed-media information is now held in computerised form. This information is available to office workers on their desktop. However, it is believed that substantial benefits could be accrued by making this information available to those workers who operate in the field, i.e. by moving the desktop into the field. This paper reports on the initial findings of the DTI/SERC supported MOST project which aims to produce a pilot system to demonstrate how mixed-media information can be exploited in the field using mobile computers and wide-area radio communications as enabling technologies.
Potential and feasibility of parallel MRI at high field (2006)

This survey focuses on the fusion of two major lines of recent progress in MRI methodology: parallel imaging with receiver coil arrays and the transition to high and ultra-high field strength for human applications. As discussed in this paper, combining the two developments has vast potential due to multiple specific synergies. First, parallel acquisition and high field are highly complementary in terms of their individual advantages and downsides. As a consequence, the joint approach generally offers enhanced flexibility in the design of scanning strategies. Second, increasing resonance frequency changes the electrodynamics of the MR signal in such a way that parallel imaging becomes more effective in large objects. The underlying conceptual and theoretical considerations are reviewed in detail. In further sections, technical challenges and practical aspects are discussed. The feasibility of parallel MRI at ultra-high field is illustrated by current results of parallel human MRI at 7 T.
Introduction — the Study of Tissue Materials (2018)

The subject of biomaterials includes not only materials of synthetic origin intended for implantation in the human body in order to support or replace some of its structures but includes also those same bodily structures, i.e. the tissue materials. The particular study of human tissue materials will contribute to an understanding of the fundamental properties of those tissues, to the establishment of relationships between normal and pathological conditions, and to the study of interactions between tissues and surgical implants. Biological acceptability often referred to as biocompatibility is the study of the interaction of implant materials with the tissues which receive them. Information obtained from the study of living materials includes: a developing fund of knowledge of tissue properties and structure; formation of a basis for the understanding of tissue-implant reactions; and a definition of parameters required adequately to treat disease and injury.
Actors: a model for reasoning about open distributed systems (2001)

this paper abstracts some fundamental aspects of open systems. Actors provide a natural generalization for objects -- encapsulating both data and procedures. However, actors differ from sequential objects in that they are also units of concurrency: each actor executes asynchronously and its operation may overlap with other actors. This unification of data abstraction and concurrency is in contrast to language models, such as Java, where an explicit and independent notion of thread is used to provide concurrency. By integrating objects and concurrency, actors free the programmer from having to write explicit synchronization code to prevent harmful concurrent access to data within an object
Impedance studies on Li insertion electrodes of Sn oxide and oxyfluoride (1996)

Films of Sn oxide and oxyfluoride were made by reactive rf magnetron sputtering onto ITO-coated glass. We analyzed the composition by Rutherford backscattering spectrometry, the structure by x-ray diffraction, and the surface topography by atomic force microscopy. Li intercalation from a liquid electrolyte was more facile in the oxide than in the oxyfluoride, as found from cyclic voltammetry. Impedance spectra were taken for a wide range of frequencies and polarizing voltages. Nyqvist diagrams were interpreted from a circuit model with elements representing Li insertion at the electrolyte/film interface and electron insertion at the film/ITO interface. The data were consistent with a fractal surface of the Sn oxide film, with a dimension in excellent agreement with measures obtained through several independent techniques. The chemical diffusion coefficient was ∼10−13 cm2/s and slightly decreasing with increasing potential for all films.
Barge-In- And Noise-Free Spoken Dialogue Interface Based On Sound Field Control And Semi-Blind Source Separation (2007)

Publication in the conference proceedings of EUSIPCO, Poznan, Poland, 2007
Transplantation of the lungs and heart and lung for patients with severe pulmonary complications from sarcoidosis. (1990)

Heart-lung transplantation is now a feasible treatment for patients with end-stage pulmonary sarcoidosis. Recurrence of a sarcoidosis in the transplanted lungs may occur, but has not been a clinical problem.
Reduction of Paraoxonase Expression Followed by Inactivation across Independent Semiaquatic Mammals Suggests Stepwise Path to Pseudogenization (2023)

Convergent adaptation to the same environment by multiple lineages frequently involves rapid evolutionary change at the same genes, implicating these genes as important for environmental adaptation. Such adaptive molecular changes may yield either change or loss of protein function; loss of function can eliminate newly deleterious proteins or reduce energy necessary for protein production. We previously found a striking case of recurrent pseudogenization of the Paraoxonase 1 (Pon1) gene among aquatic mammal lineages-Pon1 became a pseudogene with genetic lesions, such as stop codons and frameshifts, at least four times independently in aquatic and semiaquatic mammals. Here, we assess the landscape and pace of pseudogenization by studying Pon1 sequences, expression levels, and enzymatic activity across four aquatic and semiaquatic mammal lineages: pinnipeds, cetaceans, otters, and beavers. We observe in beavers and pinnipeds an unexpected reduction in expression of Pon3, a paralog with similar expression patterns but different substrate preferences. Ultimately, in all lineages with aquatic/semiaquatic members, we find that preceding any coding-level pseudogenization events in Pon1, there is a drastic decrease in expression, followed by relaxed selection, thus allowing accumulation of disrupting mutations. The recurrent loss of Pon1 function in aquatic/semiaquatic lineages is consistent with a benefit to Pon1 functional loss in aquatic environments. Accordingly, we examine diving and dietary traits across pinniped species as potential driving forces of Pon1 functional loss. We find that loss is best associated with diving activity and likely results from changes in selective pressures associated with hypoxia and hypoxia-induced inflammation.
The Development of a Realtime Remote Monitoring System for the Subsidence of Building (2013)

A system, which is real-time, remote, automatic for monitoring the subsidence of building, is introduced. Hydrostatic leveling, displacement sense by electromagnetism, computer technology are integrated into the system. The system can realize real-time, continuous acquisition and management of the measured data, and when the quantity and speed of the subsidence exceed the certain warning value,the system can realize automatic early-warning. Compared with geometrical leveling, the system has advantages of high accuracy, real time, continuous, unattended, remote, wireless for monitoring and early-warning.
Amino acid substitutions in specific proteins correlate with farnesol unresponsiveness in Candida albicans (2023)

It is known that large genomic changes, such as recombinations and gene flow (losses and gains), can cause major phenotypic changes in pathogens. However, it is still not well known or documented how more subtle changes, such as amino acid substitutions, play a role in the adaptation of pathogens. The present study shows that amino acid changes can modulate C. albicans yeast's response to farnesol. This study also improves our understanding of the network of proteins involved in the response to farnesol, and of the involvement of amino acid substitutions in cellular behavior.
Advanced RNP to ILS Autoland Approaches for Optimal Benefits from PBN: Flight Testing Procedures with an A320 (2016)

We report on the the performance of our Airbus 320 during novel advanced required navigation performance (RNP) procedures which contain a fixed radius turn that delivers the aircraft onto a short ILS precision final. The three main areas of interest of the flight trials were the performance of the autoland capability, vertical path following during the RNP part of the procedure and lateral path following during the transition from RNP to localizer guidance.
Calibrating image roughness by estimating Lipschitz exponents, with applications to image restoration (2008)

Most images f(x,y) are not smoothly differentiable functions of x and y, but display edges, localized singularities, and other significant fine-scale roughness, or texture. Correct characterization and calibration of image roughness is vital in many image processing tasks. The L1 Lipschitz exponent , where 0<1, measures fine-scale image roughness provided the image is relatively noise free. A recently developed mathematical technique for estimating is described. The method is based on successively blurring the image by convolution with increasingly narrower Gaussians, using commonly available fast Fourier transform algorithms. Instructive examples are used to illustrate the quantitative changes in that occur when an image is either degraded or restored. Of particular interest are the documented changes in that accompany APEX blind deconvolution of real images from the Hubble space telescope, from magnetic resonance imaging and positron emission tomography brain scans, and from state-of-the-art nanoscale scanning electron microscopy. Additional applications include monitoring of image sharpness and imaging performance in imaging systems, evaluation of image reconstruction software quality, detection of abnormal fine structure in biomedical images, and monitoring of surface finish in industrial applications.
Real-Time Objective Measurement of Accommodation While Reading (2010)

Purpose: To determine the feasibility of collecting accurate, continuous accommodative data during reading.\nIntroduction: Both clinicians and researchers alike have seen a need to measure accommodation during reading of continuous text. In the past, obtaining these measures has been hampered by off-axis effects caused by eye movements.
Role of the Gut Liver Axis in the Pathobiology of Cholangiopathies: Basic and Clinical Evidence (2023)

The &amp;ldquo;Gut-Liver Axis&amp;rdquo; refers to physiological bidirectional interplay between the gut and its microbiota and the liver which, in health, occurs thanks to a condition of immune tolerance. In recent years, several studies have shown that, in case of modifications of gut bacterial homeostasis or impairment of intestinal barrier functions, cholangiocytes, which are the epithelial cells lining the bile ducts, activate innate immune responses against gut-derived microorganisms or bacterial products that reach the liver via enterohepatic circulation. Intestinal dysbiosis or impaired intestinal barrier functions expose cholangiocytes to an increasing amount of microorganisms and may exacerbate inflammatory responses thus leading to fibrotic remodeling of the organ. The present review focuses on the role of the gut liver axis in the pathogenesis of cholangiopathies.
An Annulation Reaction for the Synthesis of Morpholines, Thiomorpholines, and Piperazines from β‐Heteroatom Amino Compounds and Vinyl Sulfonium Salts (2008)

Heterocycling: Diphenyl vinyl sulfonium salt 1 acts first as an electrophile, then a base, and then again as an electrophile in this operationally simple, high yielding, one-pot synthesis of pharmacologically important morpholines, thiomorpholines, and piperazines. Compound 1 is an excellent synthon for the 1,2-ethane dication.
ELISA FOR RANKL-OPG COMPLEX IN MOUSE SERA (2010)

A sensitive sandwich enzyme-linked immunosorbent assay (ELISA) for the mouse RANKL-OPG complex was developed by utilizing a polyclonal antibody that recognizes mouse soluble RANKL as an immobilized capture component and mouse OPG IgG labeled with peroxidase. We could quantify the RANKL-OPG complex level (detection limit: 1 pmol/L). Employing this assay system, we demonstrated that the RANKL-OPG complex was constitutively present in the serum of OPG+/- mice, but not in that of OPG-/- or wild-type C57BL/6 J mice.
SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF NEW SULFONAMIDE ISOXAZOLO[5,4-b]PYRIDINE DERIVATIVES. (2016)

A series of novel sulfonamide isoxazolo[5,4-b]pyridines were synthesized. The substrates for their synthesis were 3-aminoisoxazolo[5,4-b]pyridine and selected aryl sulfonic chlorides, chlorosulfonic acid and selected amines. Reactions were carried out using the classical and microwave methods. Selected compounds were tested towards antibacterial and antiproliferative activity. The structure of the obtained new derivatives was determined by elemental analysis and acquired IR and 1H NMR spectra. Among the tested compounds: N- isoxazolo[5,4-b]pyridine-3-yl-benzenesulfonamide (2) and N-isoxazolo[5,4-b]pyridine-3-yl-4-methylbenzene-sulfonamide (5) showed antimicrobial activity towards Pseudomonas aeruginosa (ATCC 27853) and Escherichia coli (ATCC 25922) at doses: 125, 250 and 500 µg. Both compounds showed a 50% inhibition of proliferation of breast carcinoma cell line MCF7 at concentrations of 152.56 µg/mL and 160 161.08 µg/mL, respectively.