gebhart/patrepeval huggingface dataset:
Slow-Wave Mode Rectification on Non-Linear Microstrip (1997)

AbstractThis paper covers the theory and evaluation of the rectifying and propagation properties of two non-linear transmission lines for utility power rectification. Electromagnetic fields are launched on these microstructures and rectification is simultaneously induced along their lengths. A current-generator elemental model was developed and implemented; the behavior of the model was compared to that of experimental findings for an Al-Si Schottky transmission line and for a Cd/Bi-Se transmission line. This paper establishes the first general investigation of such structures rectifying behavior and provides the first indication that slow-wave mode operation is critical to the successful implementation of such devices.Key Words: Non-linear microstripRectifying microstripMicrowave power rectificationNon-linear transmission lineWireless utility power transmission. Wideband detection Additional informationNotes on contributorsL. E. WinkelmannLuke E. Winkelmann and T. Koryu Ishii are affiliated with the Department of Electrical and Computer Engineering, Marquette University, 1515 W. Wisconsin Avenue, Milwaukee, WI 53233T. K. IshiiLuke E. Winkelmann and T. Koryu Ishii are affiliated with the Department of Electrical and Computer Engineering, Marquette University, 1515 W. Wisconsin Avenue, Milwaukee, WI 53233
Particulate interlayer toughening of dicyanate matrix composites (1993)

Abstract Toughening of dicyanate matrix composites with particulate‐modified resin‐rich interlayers was investigated in this study. Specifically, the cure behavior, viscosity, and fracture toughness of the modified dicyanate systems were analyzed. Creation of a layered composite structure showed no improvement in Mode 1 interlaminar fracture toughness (GIc) , but greatly increased the Mode II interlaminar fracture toughness (GIIc). Furthermore, the concentration of modifier particles in the interlayer resin was found to directly affect the toughness improvement and fracture path.
Double-blind, randomized phase III study to compare the efficacy and safety of CT-P6, trastuzumab biosimilar candidate versus trastuzumab as neoadjuvant treatment in HER2 positive early breast cancer (EBC). (2017)

510 Background: CT-P6 (C) is a proposed biosimilar to trastuzumab. This trial (NCT02162667) evaluated the similarity of C and trastuzumab in efficacy and safety for HER2+ EBC. Methods: 549 patients with HER2+ EBC were randomized to receive C (n=271) or trastuzumab (n=278) in combination with docetaxel (Cycles 1-4) and 5-fluorouracil, epirubicin, and cyclophosphamide (Cycles 5-8). C or trastuzumab was administered at 8 mg/kg (Cycle 1 only) followed by 6 mg/kg every 3 weeks. The primary endpoint was pathological complete response (pCR) rate at surgery. Secondary endpoints were overall response rate (ORR), PK, PD and safety. After surgery, patients received adjuvant C or trastuzumab to complete a total of 1-year treatment. Results: The pCR rate was 46.8% for C and 50.4% for trastuzumab. The 95% CIs for the risk ratio estimate were within the equivalence margin (0.74, 1.35) in PPS and ITT analyses. Other efficacy endpoints were similar between C and trastuzumab. The proportion of patients with at least 1 treatment-emergent SAE was 6.6% for C and 7.6% for trastuzumab. Only 1 patient in each group withdrew treatment due to significant LVEF decrease. Infusion-related reaction was reported for 8.5% of patients in C and 9.0% of patients in trastuzumab. Conclusions: This study demonstrated the similarity of efficacy in terms of pCR between CT-P6 and trastuzumab in EBC patients. Secondary efficacy endpoints also supported the similarity between CT-P6 and trastuzumab. CT-P6 was well tolerated with a similar safety profile to that of trastuzumab during the neoadjuvant period. Clinical trial information: NCT02162667. [Table: see text]
ChemInform Abstract: ON THE STEREOCHEMISTRY OF GRIGNARD ADDITION TO BICYCLO(3.3.1)NONAN‐2‐ONE. PREFERENTIAL AXIAL ATTACK ON A CYCLOHEXANONE SYSTEM BY A BULKY NUCLEOPHILE (1982)

Abstract 3 On the Stereochemistry of Grignard Addition to Bicyclo[3.3.
Composite materials with self-regulated infrared emissivity and environment responsive fibers (2023)

A composite fabric having self-regulating Infrared emissivity includes meta fibers formed with optical nanostructures and an environment (temperature and/or moisture) responsive mechanism configured to adjust a relative disposition between the optical structures to control the electromagnetic coupling therebetween, thus regulating the infrared emissivity of the composite fabric to maintain a user of the fabric in a temperature/moisture comfort zone. The environment responsive mechanism may include a temperature responsive polymer layer on the fiber capable of expansion/shrinkage depending on the applied temperature, or a moisture responsive fiber changing its shape depending on the moisture level to affect spacing between the optical nanostructures.
Folate receptor-targeted fluorescent paramagnetic bimodal liposomes for tumor imaging (2011)

FR-targeted fluorescent paramagnetic bimodal liposomes provided a novel platform for bimodal tumor imaging and theranostic delivery.
Minimum-length scheduling with rate control in wireless networks: a shortest path approach (2011)

In this paper, the minimum-length scheduling problem in wireless networks is studied, where each source of traffic has a finite amount of data to deliver to its corresponding destination. Our objective is to obtain a joint scheduling and rate control policy to minimize the total time required to deliver this finite amount of data from all sources. First, networks with time-invariant channels are considered. An optimal solution is provided by formulating the minimum-length scheduling problem as finding a shortest path on a single-source directed acyclic graph. However, finding the shortest paths is computationally hard since the number of vertices and edges of the graph increases exponentially in the number of network nodes, as well as in the initial traffic demand values. Toward this end, a simplified version of the problem is considered for which we explicitly characterize the optimal solution. Next, our results are generalized to time-varying channels. First, it is shown that in case of time-varying channels, the minimum-length scheduling problem can be formulated as a stochastic shortest path problem and then an optimal policy is provided that is based on stochastic control. Finally, our analytical results are illustrated with a set of numerical examples.
Analysis of pathological and clinical characteristics of cervical conization according to age group in Japan (2020)

Post-conization management of patients aged ≥50 years requires considering the high rates of detection of more advanced lesions post-operatively, positive surgical margins, and recurrence. Cerclage should not be performed post-conization without careful consideration.
CTNI-24. A PHASE 2 STUDY OF TRAMETINIB FOR PATIENTS WITH PEDIATRIC GLIOMA WITH ACTIVATION OF THE MAPK/ERK PATHWAY. TRAM-01 (2020)

Abstract BACKGROUND Pediatric low-grade gliomas (PLGG) are the most frequent brain tumors in children. It is known that the majority of PLGG have activation of the MAPK/ERK pathway. METHODS This multicenter phase II included three progressing/refractory PLGG groups: NF1 patients, KIAA1549-BRAF fusion patients and patients with other activation of the MAPK/ERK pathway (excluding V600E). Primary objective is to evaluate overall response rate after daily oral trametinib administration for 18 cycles each 28 days duration. Secondary objectives include the assessment of progression-free survival, tolerability of trametinib, serum levels of trametinib and evaluation of quality of life during treatment. RESULTS As of June 1 2020, 37 patients have been enrolled (NF1: 7 patients, KIAA1549-BRAF fusion: 22, other: 8 (including 5 patients with FGFR1 alterations). Median age is 9.3 years (range 2.3–25.4). Median follow-up is 8.8 months (range 0–19.3). Twenty-eight patients are evaluable. Best response includes: 4 partial response (PR) (14%), 5 minor response (MR) (18%), 18 stable disease (64%), 1 progressive disease (3.5%). Median time to response is 2.8 months (range 2.4–11.3). Median duration of response is 8.0 months (range 0.6–16.8. Progression free survival at 12 months is 83.1% (95% CI 70.5–98.0%) and median progression free survival has not reached. Nine patients (24%) discontinued treatment: 3 for progressive disease, 4 adverse events (3 alanine aminotransferase increase, 1 paronychia), 2 for other reasons. CONCLUSION Trametinib is a potentially effective targeted therapy for patients with recurrent/refractory PLGG. Overall treatment is well tolerated. This ongoing trial will continue to gather data on response rate, duration of response and safety of trametinib for PLGG.
Neuroprotective Effect of Halophyte Salicornia herbacea L. Is Mediated by Activation of Heme Oxygenase-1 in Mouse Hippocampal HT22 Cells (2017)

Salicornia herbacea L. (glasswort, tungtungmadi in Korean), a halophyte that grows in salt marshes and muddy seashores along the western coast of Korea, has been used as a seasoning vegetable and a folk medicine for intestinal ailments, nephropathy, and hepatitis. As the salt-tolerant herb was reported to contain antioxidants, including tungtungmadic acid, quercetin, and chlorogenic acid, we hypothesized that the ethanolic extract of S. herbacea L. (SH extract) enriched with antioxidative compounds will have neuroprotective activity. The herbal extract and its methylene chloride (MC) fraction showed a strong protective effect against glutamate-induced cell death in murine hippocampal HT22 cells. In addition, SH extract and MC fraction not only scavenged reactive oxygen species efficiently but also caused nuclear translocation of nuclear factor (erythroid-derived 2)-like 2 and subsequently significant induction of antioxidant enzymes such as NAD(P)H:quinone oxidoreductase, heme oxygenase 1 (HO-1), and glutathione reductase. Inhibition of the antioxidant enzyme HO-1 by tin protoporphyrin abolished the neuroprotective effect of the SH extract, suggesting an important role of HO-1 in protection against glutamate-induced neural damage. Metabolite profiling for ethanolic extract and solvent fractions of the herb suggested that diosmetin and a few unidentified compounds were responsible for the neuroprotective effect. Taken together, SH extract and its MC fraction exhibited a neuroprotective effect through Nrf2-mediated induction of antioxidant enzymes, such as HO-1, and warrant further in vivo and clinical studies to confirm its effects and potentially develop a neuroprotective salt substitute or dietary supplement.
Fluid Mass Associated with an Axisymmetric Parachute Canopy (1977)

An analytical technique for calculating the fluid mass associated with parachute canopies of arbitrary axisymmetric cross section operating in an in viscid, incompressible fluid is presented. The effects of porosity, both nominal and geometric, are included. The procedure replaces the physical parachute canopy with a mathematical vortex sheet of a strength which is determined through application of velocity boundary conditions. The strength then is used to find the fluid kinetic energy. Equating this energy to the system translational kinetic energy gives the mass in question. Final and intermediate results compare favorably with those of previous analysis and experiment. I. Introduction K NOWLEDGE of the air mass associated with the trajectory of a parachute canopy is required to describe that trajectory analytically. Because of the complexities associated with typical canopy geometries and the porous nature of their surfaces, computations in the past have relied very heavily upon experimental determination of this mass. This paper details a procedure for calculating the sum of included and additional mass inherent in the axial motion of parachutes with arbitrary axisymmetric cross sections. II. Analysis Lambl gives the kinetic energy of a stream of vortex rings immersed in an incompressible, inviscid fluid which is at rest at infinity as
Abstract CT140: Pilot study of “hyperfractionated” anti-prostate specific membrane antigen (PSMA) radioimmunotherapy (177Lu-J591) for progressive metastatic castration-resistant prostate cancer (mCRPC) (2016)

Abstract Background: Phase I and II single dose 177Lu?J591 studies have been published demonstrating safety and efficacy in mCRPC. We reported a study of fractionated-double dose 177Lu?J591 (2 doses given 2 weeks apart), demonstrating the ability to administer higher cumulative doses with a dose-response and also equal or less toxicity. As a single-dose, 70 mCi/m2 results in at least 30% declines in 47% with 41% receiving a platelet transfusion. When administered in 2 divided doses, 80 mCi/m2 results in 25% PSA response with 25% transfusion; 90 mCi/m2 results in 59% response with 65% getting transfused. We hypothesize that additional dose-fractionation will allow a higher cumulative dose with less toxicity. Methods: Patients with progressive mCRPC with normal neutrophil and platelet counts were enrolled in a planned 6-patient pilot study. No selection for PSMA expression was performed. 177Lu-J591 was administered at 25 mCi/m2 every 2 weeks until the emergence of grade 2 myelosuppression. Planar imaging of 177Lu?J591 at 6?8 days following the 1st and 4th doses was performed. Pre- and post-treatment PSA and CTC counts (CellSearch) were measured. Results: 6 men median age 68.5 (range 50-79), PSA 84.8 (14.7-2265), 67% elevated LDH, 83% unfavorable CTC count, 67% prior chemo, all prior exposure to abi/enza. Five (83%) with bone mets, 5 (83%) with lymph node mets, and 2 (33%) with visceral mets. Pts received a range of 3-6 doses (cumulative 75-150 mCi/m2 of 177Lu-J591). Two (33%) had &amp;gt;30% PSA decline and 3 (50%) had CTC count decline. Two (33%) experienced Gr 4 neutropenia (without fever), 3 (50%) had Gr 4 thrombocytopenia, and 2 (33%) had platelet transfusion. Two had worsening cytopenia following partial count recovery during periods of cancer progression, with bone marrow biopsies in both revealing infiltrative tumor without dysplasia. Targeting of 177Lu?J591 at known sites of disease was seen in all (100%) pts. Conclusions: “Hyperfractionation” of radioimmunotherapy with 177Lu?J591 is possible in a heavily pre-treated population with poor prognostic features. Targeted delivery of 177Lu occurs to known sites of disease in an unselected patient population. Study is ongoing to determine the optimal target population and dosing regimen for phase 2 study. Citation Format: Ana M. Molina, Jaspreet S. Batra, Beerinder S. Karir, Yuliya Jhanwar, Shankar Vallabhajosula, Paul J. Christos, Linda Lam, Jennifer Epstein, Irene Karpenko, Himisha Beltran, David M. Nanus, Stanley J. Goldsmith, Neil H. Bander, Scott T. Tagawa. Pilot study of “hyperfractionated” anti-prostate specific membrane antigen (PSMA) radioimmunotherapy (177Lu-J591) for progressive metastatic castration-resistant prostate cancer (mCRPC). [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr CT140.
Digital twins for collaboration and self-integration (2021)

Digital twins are digital representations of cyber-physical systems, allowing bi-directional data and control flow between them. In this paper, we introduce the digital twin concept in self-integrating and self-improving systems. Specifically, we highlight the usage of digital twin models for autonomous systems spontaneously interacting with each other and aiming to improve collaboration and mutual safety. We present the main challenges and an initial architecture to enable autonomous cyber-physical systems to collaborate, self-integrate, and self-improve during run-time.
Mutations in gonadotropin-releasing hormone signaling pathway in two nIHH patients with successful pregnancy outcomes (2016)

Polish founder mutation Arg139His in GnRHR was found in two nIHH patients originating from Western region of Russia. Common variant of GnRH-encoding gene, Trp16Ser, could possibly contribute to reproductive phenotypes in patients with heterozygous mutations of other GnRH signaling pathway genes.
Local Heat Transfer Measurements Using an Electrically Heated Thin Gold-Coated Plastic Sheet (1985)

This paper describes an experimental technique for measuring the local heat transfer coefficient in complex flows. The technique employs a gold-coated plastic sheet to generate a nearly uniform wall heat flux. The sheet is mounted on an insulated substrate of the desired shape and heating is achieved by passing an electrical current through the gold coating. Three applications of this technique are described: heat transfer downstream of an abrupt expansion, heat transfer from a cylinder in crossflow, and nonuniform circumferential heating in a pipe. For each of these applications the effect of the wall conduction on the surface heat flux is evaluated and found to be small. The effect of nonuniformities in the gold coating, and of the resistance temperature coefficient, are also evaluated and likewise are found to be quite small. Methods of correcting for each of these small effects are presented for the above applications.
Comprehensive understanding of surface roughness and Coulomb scattering mobility in biaxially-strained Si MOSFETs (2008)

We have experimentally found that tensile biaxial strain enhances the surface roughness scattering limited mobility (mu <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">sr</sub> ) of electrons, while degrades that of holes slightly, for the first time. It is also found that tensile biaxial strain enhances the Coulomb scattering mobility of holes induced by interface states (mu <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">it</sub> ) thanks to the enhancement of the averaged distance between the holes and scattering centers at the Si/SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> interface (Z <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">inv</sub> ), while degrades that induced by substrate impurity (mu <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">sub</sub> ) due to the enhancement of interband scattering. These impacts of tensile strain on mu <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">it</sub> and mu <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">sub</sub> of holes are opposite to the trend of electron ones.
Circumferential Pelvic Antishock Sheeting: A Temporary Resuscitation Aid (2002)

Acute traumatic pelvic ring instability causes severe pain and associated hemorrhage. Circumferential pelvic sheeting provides patient comfort and noninvasive, rapid, and temporary pelvic ring stability. A bed sheet is readily available, inexpensive, easily applied around the pelvis, and disposable.
Cardiovascular death in rheumatoid arthritis: A population‐based study (2005)

These results indicate that markers of systemic inflammation confer a statistically significant additional risk for cardiovascular death among patients with RA, even after controlling for traditional cardiovascular risk factors and comorbidities.
A Single‐Crystal Monomer to Single‐Crystal Polymer Reaction Activated by a Triplet Excimer in a Zipper Mechanism (2023)

A combined experimental and theoretical study focused on the elucidation of the polymerization mechanism of the crystal monomer to crystal polymer reaction of a bisindenedione compound in the solid state. The experimental description and characterization of the polymer product have been reported elsewhere and, in this article, we address the first detailed description of the polymerization process. This reaction pathway consists of the initial formation of a triplet excimer state that relaxes to an intermolecularly bonded triplet state that is the starting point of the propagation step of the polymerization. The overall process can be visualized in the monomer starting state as an open zipper in which a cursor or slider is formed by light absorption and the whole zipper is then closed by propagation of the cursor. To this end, variable-temperature electron spin resonance (ESR), femtosecond transient absorption spectroscopy, and vibrational Raman spectroscopic data have been implemented in combination with quantum chemical calculations. The presented mechanistic insight is of great value to understand the intricacies of such an important reaction and to envisage and diversify the products produced thereof.
Nichtinvasive Beatmung und körperliche Belastung bei Patienten mit COPD (2008)

The use of non-invasive ventilation (NIV) to improve physical activity in COPD patients has been addressed in several clinical investigations in the past. In general, NIV can be applied directly during exercise, but also intermittently when used for long-term treatment thereby aiming at improving physical activity during spontaneous breathing. There is increasing evidence that NIV enhances exercise capacity in COPD patients with a reduction of exercise-induced dyspnea when applied during exertion. Furthermore, physical training has been shown to produce positive results when training was performed under NIV-aided conditions. However, the results regarding tolerance of NIV, exercise ability and dyspnea are individually different. In most studies where NIV was applied during exercise, patients had no indication for long-term NIV, and patients were ventilated with low inspiratory pressures, which produced varying results. In contrast, the use of higher inspiratory pressures in hypercapnic COPD patients was more effective in enhancing exercise capacity. The intermittent application of NIV also positively affects exercise capacity in COPD patients, although different results were achieved with different ventilator strategies, mainly with a variety of inspiratory pressure levels. Different ventilation modes were used for NIV to aid exercise and for the intermittent approach in addition to different settings: CPAP, pressure support ventilation, proportional assist ventilation and controlled NIV. Therefore, it is still unclear how to define the best technique for NIV to be used in order to enhance exercise capability in COPD patients. Future studies are needed to define which subgroup of patients benefit from NIV in view of its effects on exercise. Further studies should also be aimed at clarifying which mode and which ventilator settings are most beneficial in improving exercise capability in COPD patients.