gebhart/patrepeval huggingface dataset:
Macrophage Migration Inhibitory Factor Triggers Chemotaxis of CD74+CXCR2+ NKT Cells in Chemically Induced IFN-γ–Mediated Skin Inflammation (2014)

IFN-γ mediates chemically induced skin inflammation; however, the mechanism by which IFN-γ-producing cells are recruited to the sites of inflammation remains undefined. Secretion of macrophage migration inhibitory factor (MIF), a proinflammatory cytokine, from damaged cells may promote immune cell recruitment. We hypothesized that MIF triggers an initial step in the chemotaxis of IFN-γ-producing cells in chemically induced skin inflammation. Using acute and chronic models of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin inflammation in mouse ears, MIF expression was examined, and its role in this process was investigated pharmacologically. The cell populations targeted by MIF, their receptor expression patterns, and the effects of MIF on cell migration were examined. TPA directly caused cytotoxicity accompanied by MIF release in mouse ear epidermal keratinocytes, as well as in human keratinocytic HaCaT cells. Treatment with the MIF antagonist (S,R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid methyl ester considerably attenuated TPA-induced ear swelling, leukocyte infiltration, epidermal cell proliferation, and dermal angiogenesis. Inhibition of MIF greatly diminished the dermal infiltration of IFN-γ(+) NKT cells, whereas the addition of exogenous TPA and MIF to NKT cells promoted their IFN-γ production and migration, respectively. MIF specifically triggered the chemotaxis of NKT cells via CD74 and CXCR2, and the resulting depletion of NKT cells abolished TPA-induced skin inflammation. In TPA-induced skin inflammation, MIF is released from damaged keratinocytes and then triggers the chemotaxis of CD74(+)CXCR2(+) NKT cells for IFN-γ production.
ChemInform Abstract: Electrophilic Reactions of Carbonyl Compounds and Their Derivatives. Part 8. Reactions of Vinyl Chlorides with Benzonitrile in the Presence of Acylium Salts. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Recovering Correct Reconstructions from Indistinguishable Geometry (2014)

Structure-from-motion (SFM) is widely utilized to generate 3D reconstructions from unordered photo-collections. However, in the presence of non unique, symmetric, or otherwise indistinguishable structure, SFM techniques often incorrectly reconstruct the final model. We propose a method that not only determines if an error is present, but automatically corrects the error in order to produce a correct representation of the scene. We find that by exploiting the co-occurrence information present in the scene's geometry, we can successfully isolate the 3D points causing the incorrect result. This allows us to split an incorrect reconstruction into error-free sub-models that we then correctly merge back together. Our experimental results show that our technique is efficient, robust to a variety of scenes, and outperforms existing methods.
A Rule-based Methodology for Hardware Configuration Validation in Embedded Systems (2016)

As the complexity of multicore SoCs increases, more potential system issues are arising. Hardware-related configuration issues are becoming more complicated owing to the introduction of more cores and various complex peripherals. Considering the complexity of multicore programming, consultation of the main source of guidance, i.e. the user manual, is not an efficient approach to identify such problems. Improper hardware-related configurations could lead to either functional or performance issues. Some of these issues are even subtle and hard to detect. Therefore, a rule-based validation methodology is proposed to deal with hardware-related configuration issues in an efficient and reliable way. Hardware trace is applied in this methodology to detect issues even before symptoms appear. The method directly observes the register accesses and detects bugs based on trace data. It is independent of the application as long as they are run on the given platform, which means the same method implementation could be applied to any applications on the same platform. In this paper, an initial proof-of-concept for the proposed methodology has been implemented and demonstrated on the Infineon TC29 device.
John Becker, 1932–2010 (2010)

John Becker, 1932–2010. An article from journal Urban History Review / Revue d'histoire urbaine (Encounters, Contests, and Communities: New Histories of Race and Ethnicity in the Canadian City, Part 2), on Érudit.
Eosinophilic Granulomatosis with Polyangiitis Presenting with Central Retinal Artery Occlusion During Treatment with Anti-interleukin-5 Receptor Monoclonal Antibody (2021)

Eosinophilic granulomatosis with polyangiitis (EGPA) is an anti-neutrophilic cytoplasm antibody (ANCA)-associated vasculitis characterized by asthma and eosinophilia. Although EGPA involves multiple organs, ocular involvement is infrequent and often carries a poor visual prognosis. We herein report a rare case of EGPA presenting with central retinal artery occlusion (CRAO) in which visual loss developed during treatment with anti-interleukin (IL)-5 receptor monoclonal antibody, and improvement in visual outcomes was attained after treatment combining high-dose oral corticosteroids, cyclophosphamide and an anticoagulant. Physicians should consider CRAO as an ophthalmic manifestation of EGPA in patients with severe eosinophilic asthma.
Biosynthesis of 2-Hydroxyethylphosphonate, an Unexpected Intermediate Common to Multiple Phosphonate Biosynthetic Pathways (2008)

Phosphonic acids encompass a common yet chemically diverse class of natural products that often possess potent biological activities. Here we report that, despite the significant structural differences among many of these compounds, their biosynthetic routes contain an unexpected common intermediate, 2-hydroxyethyl-phosphonate, which is synthesized from phosphonoacetaldehyde by a distinct family of metal-dependent alcohol dehydrogenases (ADHs). Although the sequence identity of the ADH family members is relatively low (34-37%), in vitro biochemical characterization of the homologs involved in biosynthesis of the antibiotics fosfomycin, phosphinothricin tripeptide, and dehydrophos (formerly A53868) unequivocally confirms their enzymatic activities. These unique ADHs have exquisite substrate specificity, unusual metal requirements, and an unprecedented monomeric quaternary structure. Further, sequence analysis shows that these ADHs form a monophyletic group along with additional family members encoded by putative phosphonate biosynthetic gene clusters. Thus, the reduction of phosphonoacetaldehyde to hydroxyethyl-phosphonate may represent a common step in the biosynthesis of many phosphonate natural products, a finding that lends insight into the evolution of phosphonate biosynthetic pathways and the chemical structures of new C-P containing secondary metabolites.
Transcutaneous oxygen tension and toe blood pressure as predictors for outcome of diabetic foot ulcers. (1999)

The results indicate that TcPO2 is a better predictor for ulcer healing than TBP in diabetic patients with chronic foot ulcers, and that the probability of ulcer healing is low when TcPO2 is < 25 mmHg.
Supplementary Figure 1 from Noncytotoxic Differentiation Treatment of Renal Cell Cancer (2023)

Supplementary Figure 1 from Noncytotoxic Differentiation Treatment of Renal Cell Cancer
Pilot Study with regard to the Wound Healing Activity of Protein fromCalotropis procera(Ait.) R. Br. (2012)

We provide the scientific basis for the use of Calotropis procera for treating skin and wound infections in traditional medicine. The aqueous extract of stem-bark of C. procera exhibited more pronounced potent antimicrobial activity. Calo-protein was purified and identified from the most-active aqueous extracts of C. procera and showed broad-spectrum activity. Calo-protein inhibited the growth of S. aureus and E. aerogenes effectively at 25 μg/ml concentration. Mice topically treated with Calo-protein revealed significant wound healing after 14 days comparable to fusidic acid (FA) as positive control. This protein was devoid of cytolytic effect even at higher concentrations on skin cells after 24 h. Further investigation of this Calo-protein of C. procera on bacterial inhibition may provide a better understanding of the scientific basis and justification for its use in traditional medicine.
Transcriptome Analysis of the Arabidopsis Megaspore Mother Cell Uncovers the Importance of RNA Helicases for Plant Germline Development (2011)

Germ line specification is a crucial step in the life cycle of all organisms. For sexual plant reproduction, the megaspore mother cell (MMC) is of crucial importance: it marks the first cell of the plant "germline" lineage that gets committed to undergo meiosis. One of the meiotic products, the functional megaspore, subsequently gives rise to the haploid, multicellular female gametophyte that harbours the female gametes. The MMC is formed by selection and differentiation of a single somatic, sub-epidermal cell in the ovule. The transcriptional network underlying MMC specification and differentiation is largely unknown. We provide the first transcriptome analysis of an MMC using the model plant Arabidopsis thaliana with a combination of laser-assisted microdissection and microarray hybridizations. Statistical analyses identified an over-representation of translational regulation control pathways and a significant enrichment of DEAD/DEAH-box helicases in the MMC transcriptome, paralleling important features of the animal germline. Analysis of two independent T-DNA insertion lines suggests an important role of an enriched helicase, MNEME (MEM), in MMC differentiation and the restriction of the germline fate to only one cell per ovule primordium. In heterozygous mem mutants, additional enlarged MMC-like cells, which sometimes initiate female gametophyte development, were observed at higher frequencies than in the wild type. This closely resembles the phenotype of mutants affected in the small RNA and DNA-methylation pathways important for epigenetic regulation. Importantly, the mem phenotype shows features of apospory, as female gametophytes initiate from two non-sister cells in these mutants. Moreover, in mem gametophytic nuclei, both higher order chromatin structure and the distribution of LIKE HETEROCHROMATIN PROTEIN1 were affected, indicating epigenetic perturbations. In summary, the MMC transcriptome sets the stage for future functional characterization as illustrated by the identification of MEM, a novel gene involved in the restriction of germline fate.
Virtually 100% of melanoma cell lines harbor alterations at the DNA level withinCDKN2A, CDKN2B, or one of their downstream targets (1998)

The cyclin-dependent kinase inhibitor 2A (CDKN2A), or p16INK4a, gene on 9p21 is important in the genesis of both familial and sporadic melanoma. Homozygous deletions and intragenic mutations of this gene have been identified in both melanoma cell lines and uncultured tumors, although the frequency of these alterations is higher in the cell lines. A proportion of melanoma cell lines and tumors without deletion/mutation of CDKN2A have also been determined to harbor transcriptionally inactive CDKN2A alleles or carry alterations in other components of the pathway through which p16INK4a acts on pRb to mediate cell cycle arrest. We sought to determine the frequency of these alternative events (in relationship to those that specifically inactivate CDKN2A) in a panel of 45 melanoma cell lines. Surprisingly, at the DNA level alone, 96% (43/45) of melanoma cell lines examined were found to be deleted/mutated/methylated for CDKN2A (34/45), homozygously deleted for CDKN2A's neighbor and homolog CDKN2B (6/45), and/or mutated/amplified for CDK4 (5/45). In two of these 43 cases, homozygous deletions of CDKN2A were detected along with a CDK4 mutation or amplification of the cyclin D1 (CCND1) gene. The latter discoveries were made in two of three cell lines which harbored extremely large (3-6 Mb) homozygous deletions on 9p21; all other homozygous deletions in similarly affected cell lines (N = 23) were confined to a region immediately surrounding the CDKN2A/CDKN2B loci. These results suggest that (1) only melanoma cells with alterations in this pathway can be propagated in culture, and (2) the homozygous deletions on 9p21 in the cell lines, which are also mutated/amplified for CDK4 or CCND1, could serve to target tumor suppressor genes other than CDKN2A.
4K Video over SMPTE 2022-5/6 Workflows (2016)

The next generation of live television is here! Unfortunately, the necessary bandwidth for ultrahigh-definition-television resolution video and higher frame rates for live uncompressed video transport is not. Uncompressed 4K video at 60 frames/s 4:2:2 requires 12 Gbits/s and even more for 4:4:4, which causes a problem for video transport across 10 Gbit/s Ethernet networks. “Lightly compressed” 4K is needed to fit in a single 10 Gbit Ethernet (GbE) cable. For the industry's existing and deployed infrastructure, the compression has to be capable of leveraging the already deployed SMPTE ST 2022-5/6 equipment. <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1,2</sup> Visually lossless compression for a single 4K stream over a 10 GbE link is also ideal. This paper explores the issues described and suggests the technologies required to fix the problem.
Advanced Components for Applications in S-Band and X-Band Radars (2008)

Performance issues in S-Band and X-Band radar applications, have been investigated in parallel paths. The first approach continued with the basic GaAs based MESFET and pHEMT devices with the addition of field plate structures to enhance the transistor source-to-drain breakdown, enabling operation at higher voltages and producing significant improvements in device operation. The second direction questioned the basic material properties underlying the device structures. This methodology has led to the investigation of a number of pHEMT and HEMT designs based on SiC, GaN on SiC, and GaN on silicon devices for both S-Band and X-Band radar applications.
Thresholds of Quality: Implications for the Social Development of Children in Center-based Child Care (1992)

We assessed the quality of center child care relationships with adults and peers for 414 children (ages 14 to 54 months). Classrooms were classified by ratio and group size provisions of the Federal Interagency Day Care Requirements (FIDCR) and by the Early Childhood and Infant and Toddler Environmental Rating Scales. Children cared for in classrooms meeting FIDCR ratios were more likely to be in classrooms rated as good or very good in caregiving and activities. Children in classrooms rated as good or very good in caregiving were more likely to be securely attached to teachers. Securely attached children were more competent with peers. Children cared for in classrooms meeting FIDCR group size were more likely to be in classrooms rated higher in activities. Children in classrooms rated high in activities were likely to orient to both adults and peers. Children with social orientations to adults and peers were more competent with peers.
A Long-Distance RF-Powered Sensor Node with Adaptive Power Management for IoT Applications (2017)

We present a self-sustained battery-less multi-sensor platform with RF harvesting capability down to -17 dBm and implementing a standard DASH7 wireless communication interface. The node operates at distances up to 17 m from a 2 W UHF carrier. RF power transfer allows operation when common energy scavenging sources (e.g., sun, heat, etc.) are not available, while the DASH7 communication protocol makes it fully compatible with a standard IoT infrastructure. An optimized energy-harvesting module has been designed, including a rectifying antenna (rectenna) and an integrated nano-power DC/DC converter performing maximum-power-point-tracking (MPPT). A nonlinear/electromagnetic co-design procedure is adopted to design the rectenna, which is optimized to operate at ultra-low power levels. An ultra-low power microcontroller controls on-board sensors and wireless protocol, to adapt the power consumption to the available detected power by changing wake-up policies. As a result, adaptive behavior can be observed in the designed platform, to the extent that the transmission data rate is dynamically determined by RF power. Among the novel features of the system, we highlight the use of nano-power energy harvesting, the implementation of specific hardware/software wake-up policies, optimized algorithms for best sampling rate implementation, and adaptive behavior by the node based on the power received.
TJ6: The Pregnancy‐Associated Cytokine (1996)

These studies have demonstrated that TJ6m protein can be measured in women prior to a spontaneous abortion based on expression of TJ6 on CD56-positive NK cells. This suggested to us a possible regulator function for TJ6 during pregnancy. We have shown that in T cells only crosslinking of the T-cell receptor can upregulate TJ6 expression and the other activators, such as mitogens, do not. A clear discrepancy in the pattern of expression of TJ6 on CD56 and CD19-positive cells was noted between successful and unsuccessful pregnancies. A successful pregnancy is denoted by TJ6 expression on B cells, whereas in a potential spontaneous abortion there is TJ6 expression on both NK and B cells.
High sensitivity of strong-field multiple ionization to conical intersections (2012)

Nonradiative energy dissipation in electronically excited polyatomic molecules proceeds through conical intersections, loci of degeneracy between electronic states. We observe a marked enhancement of laser-induced double ionization in the vicinity of a conical intersection during a non-radiative transition. We measured double ionization by detecting the kinetic energy of ions released by laser-induced strong-field fragmentation during the ring-opening transition between 1,3-cyclohexadiene and 1,3,5-hexatriene. The enhancement of the double ionization correlates with the conical intersection between the HOMO and LUMO orbitals.
Prediction of LOFT Test L1-4: NRC Standard Problem 7. [PWR] (1980)

The EI/EPRI prediction of Standard Problem 7 is documented for submittal to the United States Nuclear Regulatory Commission. The analysis of the first 52 seconds of the transient and the submittal report were completed in June 1977, prior to the release of the experimental data. The RETRAN computer code (RET07A) was used to analyze the LOFT test L1-4 which was an isothermal 200% cold leg break blowdown. Documentation is also presented for extensive post data release analysis including several significant model changes and a revised calculation to 22 seconds into the 70-second transient.
Demonstrating the Critical Role of Solvation in Supported Ti and Nb Epoxidation Catalysts via Vapor-Phase Kinetics (2020)

Catalytic oxidation of hydrocarbons with hydrogen peroxide (H2O2) has been of the utmost importance for several decades. The vast majority of studies have been performed in the condensed phase, even though condensed phases introduce complex solvent effects and can promote the leaching of active sites. In response, we have built a custom reactor system to understand H2O2 activation and selective oxidation in the vapor-phase. In this report, we study the epoxidation of cyclohexene with H2O2 over four Lewis-acidic metal oxide catalysts: Ti and Nb grafted on SiO2 and on the Zr based metal–organic framework, NU-1000. The M–SiO2 materials are highly selective to the formation of epoxides and diols, as they can be in the condensed phase, while the NU-1000 based materials are far more prone to overoxidation to CO2, which appears to be connected to their strong reactant adsorption. Apparent activation energies are calculated for all materials when operating in the same kinetic regime, and the heats of cyclohexene adsorption into their pores are then used to directly compare intrinsic enthalpies of activation in the vapor vs condensed phase for the M–SiO2 catalysts. Nb–SiO2 catalysts exhibit similar intrinsic enthalpies of activation in the vapor and condensed phases, whereas the condensed phase transition state in Ti–SiO2 is 24 kJ/mol lower in energy than that of the same material in the vapor phase. These experiments establish another methodology for understanding the various roles of solvent in selective oxidation reactions and studying these reactions under conditions that differ significantly from the thousands of prior studies in the condensed phase.
<title>New schemes in the adjustment of bendable elliptical mirrors using a long trace profiler</title> (1997)

The Long Trace Profiler, an instrument for measuring the slope profile of long X-ray mirrors, has been used for adjusting bendable mirrors. Often an elliptical profile is desired for the mirror surface, since many synchrotron applications involve imaging a point source to a point image. Several techniques have been used in the past for adjusting the profile measured in height or slope of a bendable mirror. Underwood et al. have used collimated X- rays for achieving a desired surface shape for bent glass optics. Nonlinear curve fitting sing the simplex algorithm was later used to determine the best fit ellipse to the surface under test. A more recent method uses a combination of least squares polynomial fitting to the measured slope function in order to enable rapid adjustment to the desired shape. The mirror has mechanical adjustments corresponding to the first and second order terms of the desired slope polynomial, which correspond to defocus and coma, respectively. The higher order terms are realized by shaping the width of the mirror to produce the optimal elliptical surface when bent. The difference between desired and measured surface slope profiles allows us to make methodical adjustments to the bendable mirror based on changes in the signs and magnitudes of the polynomial coefficients. This technique gives rapid convergence to the desired shape of the measured surface, even when we have no information about the bender, other than the desired shape of the optical surface. Nonlinear curve fitting can be used at the end of the process for fine adjustments, and to determine the over all best fit parameters of the surface. This technique cold be generalized to other shapes such as toroids.
Immunologic Memory Induced by a Glycoconjugate Vaccine in a Murine Adoptive Lymphocyte Transfer Model (1998)

ABSTRACT We have developed an adoptive cell transfer model in mice to study the ability of a glycoprotein conjugate vaccine to induce immunologic memory for the polysaccharide moiety. We used type III capsular polysaccharide from the clinically relevant pathogen group B streptococci conjugated to tetanus toxoid (GBSIII-TT) as our model vaccine. GBS are a major cause of neonatal infections in humans, and type-specific antibodies to the capsular polysaccharide protect against invasive disease. Adoptive transfer of splenocytes from mice immunized with the GBSIII-TT conjugate vaccine conferred anti-polysaccharide immunologic memory to naive recipient mice. The transfer of memory occurred in a dose-dependent manner. The observed anamnestic immune response was characterized by (i) more rapid kinetics, (ii) isotype switching from immunoglobulin M (IgM) to IgG, and (iii) 10-fold-higher levels of type III-specific IgG antibody than for the primary response in animals with cells transferred from placebo-immunized mice. The adoptive cell transfer model described in this paper can be used for at least two purposes: (i) to evaluate conjugate vaccines with different physicochemical properties for their ability to induce immunologic memory and (ii) to study the cellular interactions required for an immune response to these molecules.