gebhart/patrepeval huggingface dataset:
Guanine is a growth factor for Legionella species (1986)

Evaluation of previously described chemically defined media for the growth of Legionella pneumophila showed that these media supported poor growth of several strains of L. pneumophila and did not support growth of certain of the Legionella species described later. Growth was stimulated by the dialysate from yeast extract but not by the nondialyzable fraction. Further investigations indicated that the active factors from the yeast extract dialysate were purine or pyrimidine derivatives, and certain known purines and pyrimidines were found to stimulate growth. Of these, guanine universally stimulated growth of all Legionella strains and was a growth requirement for several of the species tested. A balanced, N-(2-acetamido)-2-aminoethanesulfonic acid-buffered, chemically defined medium having guanine or a purine-pyrimidine mix is presented for the general growth of Legionella species.
Direct Asymmetric Intermolecular Aldol Reactions Catalyzed by Amino Acids and Small Peptides. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Analysis of HPLC fingerprints of Fructus Aurantii from different habitats and contents of naringin, neohesperidin and synephrine (2011)

OBJECTIVE To establish the HPLC fingerprints for assessing the quality of Fructus Aurantii from different habitats,and to determine the contents of naringin,neohesperidin and synephrine.METHODS HPLC fingerprinting and content determination methods were applied to evaluate 10 batches of Fructus Aurantii from different habitats.The samples were separated by Alltima C18 column(4.6 mm×250 mm,5 μm) using acetonitrile-0.1% phosphoric acid and 0.1% SDS water solution as mobile phase with gradient elution.The flow rate was 1.0 mL·min-1.The detection wavelengths were 224 nm for fingerprinting,283 nm for content determination of naringin and neohesperidin,and 224 nm for content determination of synephrine,respectively.RESULTS HPLC fingerprint of Fructus Aurantii was established with good separation and repeatability,which could be used for quality assessment of Fructus Aurantii.Six common peaks were defined in characteristic fingerprints,and similarity evaluation system was applied to evaluate the fingerprints of the 10 batches of Fructus Aurantii.The contents of naringin,neohesperidin and synephrine in Fructus Aurantii from different habitats were obviously different from each other.CONCLUSION The method is sensitive,repeatable and accurate,which can be used for the quality control of Fructus Aurantii.The contents of naringin,neohesperidin and synephrine vary significantly in Fructus Aurantii from different habitats,which suggests that more attention should be paid to the clinical use of Fructus Aurantii.
Architecting the Carceral State: The Fragment in Medbh McGuckian's Diaries and Walter Benjamin's 'Theses' (2021)

It seems important at this point in the conversation on Medbh McGuckian to look at her prose. This article close reads two autobiographical pieces, the diaries ‘Women are Trousers’ (2000) and ‘Rescuers and White Cloaks: Diary, 1968 – 69’ (2001). The focus here is the form: I consider these diaries as diaries, war diaries particularly, crafted through a poetics of the fragment in a close reading in which their performative functionality is contemplated together with contexts, principally the relation to history that founds the diary and the specific era, Ireland’s ‘Troubles’. These texts are not merely remarkable literary achievements but remarkable in being strikingly analogous to Walter Benjamin’s ‘Theses on the Philosophy of History’. While McGuckian names her form, in fact her texts push back on every boundary of it and, familiar from the poems, all expectations of craft and language. All this is true of Benjamin’s text: while we understand the ‘Theses’ to be philosophical writings, they are as abstruse and literary as McGuckian’s. These peculiar, fragmentary texts are generically esoteric and they are so in extraordinarily similar ways. I consider both authors as literary artists in order to suss out the rich and efficacious insights that come in ‘forgetting’, if temporarily, that Benjamin was a philosopher and ‘hearing’ him as the literary artist he (also) was, next to literary artist Medbh McGuckian.&#x0D; &#x0D; Keywords: The Diary, The Fragment, Prose Poetics, Lyric Prose, The Carceral State, The Angel of History
Size Effect of Interlacer (2000)

In order to clarify the size effect of an interlacer and easily choose conditions to process interlaced yarns with a desired number of tangles, we made 16 interlacers with various sizes of both yarn duct diameter d and air jet nozzle diameter dn and measured the number of tangles of interlaced raw yarn. Then the number of tangles was formulated as a function of the interlacer sizes d and dn the supplied air pressure p and the feed ratio F. Results obtained are as follows: (1) The polynomial combined with a Heaviside's step function expresses satisfactorily the distribution of the number of tangles, which takes maximum values as a function of p, F, d and dn. It represents very well the distributions of the maximum number of tangles and both supplied air pressure and feed ratio which give the maximum number. (2) The maximum number of tangles does not monotonously vary with d and dn, but theoptimum values of d and dn exist. Both the supplied air pressure and the feed ratio which give the maximum number of tangles monotonously increase with an increase in d and a decrease in dn.
Characterization of Polyethylene Glycol–Reinforced Alginate Microcapsules for Mechanically Stable Cell Immunoisolation (2019)

Islet transplantation within mechanically stable microcapsules offers the promise of long-term diabetes reversal without chronic immunosuppression. Reinforcing the ionically gelled network of alginate (ALG) hydrogels with covalently linked polyethylene glycol (PEG) may create hybrid structures with desirable mechanical properties. This report describes the fabrication of hybrid PEG-ALG interpenetrating polymer networks and the investigation of microcapsule swelling, surface modulus, rheology, compression, and permeability. It is demonstrated that hybrid networks are more resistant to bulk swelling and compressive deformation and display improved shape recovery and long-term resilience. Interestingly, it is shown that PEG-ALG networks behave like ALG during microscale surface deformation and small amplitude shear while exhibiting similar permeability properties. The results from this report's in vitro characterization are interpreted according to viscoelastic polymer theory and provide new insight into hybrid hydrogel mechanical behavior. This new understanding of PEG-ALG mechanical performance is then linked to previous work that demonstrated the success of hybrid polymer immunoisolation devices in vivo.
Dynamic Optimization of Subquery Processing in Grid Database (2007)

Grid database is a new research area combined with the database techniques and Grid techniques, while traditional database query and optimization techniques couldn't fully satisfy the need of Grid database because of the dynamic properties of Grid Nodes. The paper brings forward a query plan model/ NSN based on Petri net so as to describe the data relation between subquery and nodes. Based on NSN model paper further puts forward a three phases algorithm / TPs which can make dynamic optimization for subquery processing to fit for fluctuation of environment in grid , Finally the paper tests the algorithms through experiment.
Strain‐based HLA association analysis identified HLA‐DRB1*09:01 associated with modern strain tuberculosis (2017)

Tuberculosis (TB) occurs as a result of complex interactions between the host immune system and pathogen virulence factors. Human leukocyte antigen (HLA) class II molecules play an important role in the host immune system. However, no study has assessed the association between HLA class II genes and susceptibility to TB caused by specific strains. This study investigated the possible association of HLA class II genes with TB caused by modern and ancient Mycobacterium tuberculosis (MTB). The study included 682 patients with TB and 836 control subjects who were typed for HLA-DRB1 and HLA-DQB1 alleles. MTB strains were classified using a large sequence polymorphism typing method. Association analysis was performed using common HLA alleles and haplotypes in different MTB strains. HLA association analysis of patients infected with modern MTB strains showed significant association for HLA-DRB1*09:01 (odds ratio [OR] = 1.82; P-value = 9.88 × 10<sup>-4</sup> ) and HLA-DQB1*03:03 alleles (OR = 1.76; P-value = 1.31 × 10<sup>-3</sup> ) with susceptibility to TB. Haplotype analysis confirmed that these alleles were in strong linkage disequilibrium and did not exert an interactive effect. Thus, the results of this study showed an association between HLA class II genes and susceptibility to TB caused by modern MTB strains, suggesting the importance of strain-specific analysis to determine susceptibility genes associated with TB.
A Review of Some Modern Approaches to the Problem of Trend Extraction (2012)

This article presents a review of some modern approaches to trend extraction for one-dimensional time series, which is one of the major tasks of time series analysis. The trend of a time series is usually defined as a smooth additive component which contains information about the time series global change, and we discuss this and other definitions of the trend. We do not aim to review all the novel approaches, but rather to observe the problem from different viewpoints and from different areas of expertise. The article contributes to understanding the concept of a trend and the problem of its extraction. We present an overview of advantages and disadvantages of the approaches under consideration, which are: the model-based approach (MBA), nonparametric linear filtering, singular spectrum analysis (SSA), and wavelets. The MBA assumes the specification of a stochastic time series model, which is usually either an autoregressive integrated moving average (ARIMA) model or a state space model. The nonparametric filtering methods do not require specification of model and are popular because of their simplicity in application. We discuss the Henderson, LOESS, and Hodrick–Prescott filters and their versions derived by exploiting the Reproducing Kernel Hilbert Space methodology. In addition to these prominent approaches, we consider SSA and wavelet methods. SSA is widespread in the geosciences; its algorithm is similar to that of principal components analysis, but SSA is applied to time series. Wavelet methods are the de facto standard for denoising in signal procession, and recent works revealed their potential in trend analysis.
Onset and Rate of Cognitive Change Before Dementia Diagnosis: Findings From Two Swedish Population-Based Longitudinal Studies (2010)

We used data from two population-based longitudinal studies to estimate time of onset and rate of accelerated decline across cognitive domains before dementia diagnosis. The H70 includes an age-homogeneous sample (127 cases and 255 non-cases) initially assessed at age 70 with 12 follow-ups over 30 years. The Kungsholmen Project (KP) includes an age-heterogeneous sample (279 cases and 562 non-cases), with an average age of 82 years at initial assessment, and 4 follow-ups spanning 13 years. We fit mixed linear models to the data and determined placement of change points by a profile likelihood method. Results demonstrated onset of accelerated decline for fluid (speed, memory) versus crystallized (verbal, clock reading) abilities occurring approximately 10 and 5 years before diagnosis, respectively. Although decline before change points was greater for fluid abilities, acceleration was more pronounced for crystallized abilities after the change points. This suggests that onset and rate of acceleration vary systematically along the fluid-crystallized ability continuum. There is early onset in fluid abilities, but these changes are difficult to detect due to substantial age-related decline. Onset occurred later and acceleration was greater in crystallized abilities, suggesting that those markers may provide more valid identification of cases in later stages of the prodromal phase.
IC‐P‐018: Arterial stiffness is associated with amyloid deposition in the brain independent of blood pressure (2013)

Advances in PET imaging using amyloid specific ligands (e.g. PiB-PET) provide in vivo measurement of amyloid deposition in the brain, a hallmark of Alzheimer's disease (AD). One hypothesis for brain amyloid deposition is that it occurs in response to brain injury and inflammation secondary to cerebral small vessel disease (e.g. infarction and microhemorrhage). We hypothesize that arterial stiffness is associated with both white matter hyperintensities (WMH) and amyloid in the brain. We studied 92 non-demented participants aged 83–96 in a follow-up of the Gingko Evaluation of Memory (GEM) Study with measures of: brain MRI and PiB-PET; resting systolic blood pressure (SBP); diastolic blood pressure (DBP); pulse rate; and arterial stiffness by pulse wave velocity in the central (carotid-femoral (cf PWV) and heart femoral (hf PWV)), peripheral (femoral-ankle (fa PWV)), and mixed (brachial-ankle (ba PWV)) vascular beds, using a noninvasive and automated waveform analyzer (Colin Co., Komaki, Japan). Before study entry, all participants underwent ApoE-4 genotyping, detailed neuropsychological battery and adjudication of cognition by committee (n=77 normal and n=15 MCI). Nearly half (44/92) of non-demented older adults in this sub-study were PiB+ for amyloid. Amyloid deposition was associated with ba PWV and SBP. After adjustment for covariates, one standard deviation increase in ba PWV resulted in nearly a 2-fold increase in the odds of being PiB+. Additional adjustment for ApoE-4, mild cognitive impairment and SBP did not attenuate this association. Higher WMH volume was associated with increased central PWV (cf PWV (p<0.01) and hf PWV (p=0.03)) and SBP (p=0.05). Each standard deviation increase in ba PWV and cf PWV was associated with a 3 and 4-fold increase, respectively, in the odds of having both high amyloid and high WMH, relative to low amyloid and low WMH. This is the first study to show that PWV is associated with PiB-PET. Our results confirm initial reports showing associations between SBP and PiB-PET and extend this research by showing arterial stiffness is associated with in vivo amyloid deposition in non-demented individuals, independent of SBP and anti-hypertensive medication use. It will be important to determine if the prevention of elevated BP and vascular stiffness at middle-age will reduce amyloid deposition in the aging brain.
Molecular Cloning and Functional Analysis of ESGP, an Embryonic Stem Cell and Germ Cell Specific Protein (2005)

Several putative Oct-4 downstream genes from mouse embryonic stem (ES) cells have been identified using the suppression-subtractive hybridization method. In this study, one of the novel genes encoding an ES cell and germ cell specific protein (ESGP) was cloned by rapid amplification of cDNA ends. ESGP contains 801 bp encoding an 84 amino acid small protein and has no significant homology to any known genes. There is a signal peptide at the N-terminal of ESGP protein as predicted by SeqWeb (GCG) (SeqWeb version 2.0.2, http://gcg.biosino.org:8080/). The result of immunofluorescence assay suggested that ESGP might encode a secretory protein. The expression pattern of ESGP is consistent with the expression of Oct-4 during embryonic development. ESGP protein was detected in fertilized oocyte, from 3.5 day postcoital (dpc) blastocyst to 17.5 dpc embryo, and was only detected in testis and ovary tissues in adult. In vitro, ESGP was only expressed in pluripotent cell lines, such as embryonic stem cells, embryonic caoma cells and embryonic germ cells, but not in their differentiated progenies. Despite its specific expression, forced expression of ESGP is not indispensable for the effect of Oct-4 on ES cell self-renewal, and does not affect the differentiation to three germ layers.
Konstruktionsprinzip niedermolekularer organischer Halbleiter für metallfreie Photokatalyse mit sichtbarem Licht (2016)

Abstract Hier berichten wir über das strukturelle Konstruktionsprinzip niedermolekularer organischer Halbleiter als metallfreie, rein organische Photokatalysatoren, die bei Bestrahlung mit sichtbarem Licht aktiv sind. Dafür wurden zwei Serien von Elektronendonor‐ und Elektronenakzeptor‐basierten niedermolekularen und organischen Halbleitern synthetisiert, um entscheidende Anforderungen zu erfüllen wie: 1) Absorption im sichtbaren Bereich, 2) ausreichendes Photoredoxpotential und 3) lange Lebensdauer der photogenerierten Exzitonen. Die photokatalytische Aktivität wurde anhand der intermolekularen C‐H‐Funktionalisierung von elektronenreichen Heteroarenen mit Malonaten demonstriert. Eine mechanistische Studie über den lichtinduzierten Elektronentransfer zwischen dem organischen Photokatalysator, Substrat und Opferreagenz wurde beschrieben. Mit ihrem einstellbaren Absorptionsbereich und ihrer definierten energetischen Bandstruktur stellen die niedermolekularen organischen Halbleiter eine neue Klasse von metallfreien Photokatalysatoren für organische Reaktionen unter Bestrahlung mit sichtbarem Licht dar.
Etching Mechanisms of Si Containing Materials in Remote Plasma Source using NF3 based Gas Mixture (2018)

International audience
Mast Cells May Not Play a Crucial Role in the Pathogenesis of Experimental Closed Duodenal Loop–induced Pancreatitis in Rats (2002)

These results indicate that mast cells may not be crucial for the development of CDL-induced pancreatitis.
Biocontrol Efficacy Field evaluation of P. chlororaphis O6 WP expression (2021)

To test the efficacy of the P. chlororaphis O6 expression against root- knot nematode, a field trial of melon grown in marketable glasshouses was conducted in 2015. Because these glasshouses were a marketable enterprise, it wasn’t possible to have a hothouse without treatments. Three glasshouses, each with an area of 660 m2, were used, and each hothouse was planted with melon seedlings. Each hothouse had soils with the same chemical and physical parcels of a flaxen gault. The fine mildew resistant variety of melon, ‘EarlsElite’, was scattered into the glasshouses on July 1, 2015. Civilization practices recommended by the Rural Development Administration were followed. In the former time, 30 – 40 of this melon cultivar when grown in the same soils within the glasshouses was over ran with root- knot nematode. This infection rate passed in malignancy of the 2014 operation of the chemical nematicide Fosthazate GR (active component 5, 3.5 kg/660 m2 ) one week previous to broadcasting.
WE‐C‐WAB‐09: A Novel Volumetric Imaging Method Using a Sparse Subset of CBCT Projections (2013)

Purpose: : Over the preceding decade, onboard volumetric imaging utilizing cone beam CT (CBCT) has become an indispensible tool for image‐guided radiotherapy. A novel method has been developed to deform the planning CT to maximize the spatial congruence between the digitally reconstructed radiographs (DRRs) and CBCT projections. This method maps the planning CT images to the current anatomy using a sparse subset of CBCT projections. Methods: A finite element modeling methodology was developed to automatically generate adaptive meshes for a given region of interest without the need for segmentation. In this methodology, more control points are generated at organs boundaries, special tissues, contour boundaries, or high intensity gradients. The displacement of boundaries and important features is directly represented by the displacement of control points, instead of interpolation on regular grids. A splatting method was developed to generate DRRs of the deformed CT. These DRRs were compared with corresponding 2D projections from CBCT scans; as a Result , the displacement vector fields on the CT were optimized iteratively to obtain a final deformed CT image. A digital phantom was used to evaluate this method. Results: Typically 60 projections were needed to reconstruct a set of 3D images while several hundreds of projections were required for a conventional CBCT reconstruction. The feature‐based meshing method led to better results than either regular orthogonal or regular tetrahedral meshes. The image intensity results of the feature‐based meshing method were nearly identical to those of the voxel‐based method (normalized cross correlation efficient (NCC) ∼ 0.9858 vs 0.9872), while the feature‐based meshing method led to much better consistency of displacement vector fields relative to ground truth than voxel‐based method (NCC ∼ 0.8265 vs 0.6261). Conclusion: This feature‐based meshing method is capable of reconstructing volumetric images with significantly fewer projections while retaining the image quality of planning CT. This research is supported by CPRIT Individual Investigator Award RP110329.
Real-time measurement and calibration of particle charge: A comparison between DMA and E-SPART analyzer (1985)

An electrical-single particle aerodynamic relaxation time (E-SPART) analyzer was used to measure, in real time, the electrostatic charge and aerodynamic size distributions of aerosol particles on an individual basis. A TSI Model 3071 differential mobility analyzer (DMA) was used to classify the test aerosol particles according to their electrical mobility as an independent means of charge calibration. Measurements were performed in a range of 0 to +-200 electronic charges. Experimental data show a close agreement between the electrostatic charge classification by DMA and the measurements obtained by the E-SPART analyzers.
Providing an embedded software environment for wireless PDAs (2000)

The use of wireless PDAs is foreseen to outrun the one of PCs in the near future. However, for this to actually happen, adequate software environments must be devised in order to allow the execution of various types of applications. This paper introduces the base features of such an environment, which is a customizable JVM-based middleware. In particular, the middleware platform embeds services for appropriate resource management and for supporting novel PDA-oriented applications.