gebhart/patrepeval huggingface dataset:
A multicenter, single‐arm, open‐label, phase 2 study of apitolisib (GDC‐0980) for the treatment of recurrent or persistent endometrial carcinoma (MAGGIE study) (2016)

The antitumor activity noted with the use of a dose of 40 mg of apitolisib daily was limited by tolerability, especially in diabetic patients. Patients with PI3K pathway mutations may have derived enhanced benefit from apitolisib. Cancer 2016;122:3519-28. © 2016 American Cancer Society.
Crystal field analysis of different Er3+sites in LiNbO3 (2001)

Abstract The Er3+ defect in lithium niobate (LiNbO3), and the slightly different lattice environments (“sites”) it experiences, have been investigated with combined excitation-emission spectroscopy under application of hydrostatic pressure and electric fields. The results give a solid basis for a crystal field analysis which yields site-specific crystal field parameters. We found that the Er3+ sites can be classified into two groups. Firstly, the sites are distinct due to different relative arrangements of the nearest-neighbor oxygens and secondly they encounter to different local electric fields which are caused by charge compensators and other defects in a more distant neighborhood. Key Words: LiNbO3 High pressureStark effectSite-selective spectroscopy
Protective effect of anthocyanin‐rich extract from bilberry (Vaccinium myrtillusL.) against myelotoxicity induced by 5‐fluorouracil (2007)

The toxicities associated with 5-fluorouracil (5-FU), a potent broad-spectrum chemotherapeutic agent, can not only affect the morbidity and the efficacy of chemotherapy but also limit its clinical use. The objective of this study is to investigate the effects of a commercial anthocyanin-rich extract from bilberry (AREB) against 5-FU-induced myelotoxicity in vivo, and against chemosensitivity to 5-FU in vitro. A single injection of 5-FU at 200 mg/kg induced severe peripheral erythrocytopenia, thrombocytopenia and leucopenia as well as hypocellularity of the spleen and bone marrow in C57BL/6 mice. Oral administration of 500 mg/kg of AREB for 10 days significantly increased the number of red blood cells, neutrophils, and monocytes in peripheral blood to 1.2-fold, 9-fold, and 6-fold, respectively, compared with those seen after treatment with 5-FU alone (p< 0.05-0.001). The hypocellularity of the spleen and bone marrow caused by 5-FU was also distinctly alleviated in the AREB-treated group. Furthermore, AREB treatment with 50 and 100 microg/ml as a monomeric anthocyanin did not interfere with, but rather enhanced the chemotherapeutic efficacy of 5-FU in vitro. These results suggest that AREB may have protective potential against 5-FU-induced myelotoxiciy and/or the ability to enhance the chemotherapeutic effectiveness of 5-FU.
Epac2 and PLC ε contribute to the inflammatory response to cigarette smoke in vivo (2013)

β 2 ‐Agonists increase cellular cAMP by binding to G s ‐coupled receptors, leading to activation of PKA as well as the cAMP‐regulated exchange factors Epac1 and ‐2, the latter known to signal to PLCε. We showed recently that Epac activation reduces cigarette smoke (CS) extract‐induced IL‐8 release from airway smooth muscle cells by inhibiting Nf‐κB. We now studied the role of the Epac signalosome in CS‐induced airway inflammation in vivo . Mice were pretreated with vehicle, the β 2 ‐agonist fenoterol or the Epac1 and ‐2 activator 8‐pCPT and exposed to CS or filtered air for 5 days. In bronchoalveolar lavage fluid of CS exposed wild‐type mice, total inflammatory cells, macrophages and neutrophils were all increased. Treatment with fenoterol or 8‐pCPT did not alter the inflammatory response induced by CS, although fenoterol slightly increased total inflammatory cells in air exposed mice. Compared to wild‐types, the CS‐induced increase in total inflammatory cells, macrophages and neutrophils were reduced in Epac2 −/− mice, whereas specifically the neutrophils were reduced in PLCε −/− mice. In conclusion, Epac2 enhances CS‐induced airway inflammation in vivo presumably by activating PLCε. (NAF grant 3.2.09.034)
Analyse numérique de tests expérimentaux à grandes vitesses de déformation (2005)

International audience
Callable Tax-Exempt Bonds Are Too Costly (2022)

Virtually every longer-term tax-exempt municipal bond is callable, usually at par 10 years after issuance. Borrowers pay for the call option with an above-market coupon or by accepting a lower sale price. We explore how the value of the option compares to its cost. Is a fairly priced call option a good deal for the municipality? The remarkable finding is that the call option is undesirable, because its cost exceeds its expected benefit. Instead of issuing callable bonds at lower prices or with higher coupons, municipal borrowers should issue optionless bonds.
ChemInform Abstract: REDUCTION BY TRIBUTYLTIN HYDRIDE OF CARBONYL COMPOUNDS ADSORBED ON SILICA GEL‐ SELECTIVE REDUCTION OF ALDEHYDES (1979)

Abstract Die Reduktion zahlreicher Oxo‐Verbindungen (I) mit Tributylzinnhydrid (II) zu den Carbinolen (III) wird untersucht und in Tabellen aufgeführt.
Effects of Abnormal Early Rearing Environments on Fear Memory in Adult Rats (2009)

为了探讨早期饲养环境对成年后大鼠条件化恐惧的影响，实验采用巴氏恐惧条件化的方法对不同饲养环境下的大鼠进行了行为检测。具体操作为：把断奶后的大鼠饲养在3个不同的人工控制的环境中（丰富环境、社群环境和贫瘠环境）；8周后进行恐惧条件化训练和测试（指标为僵直百分比），以及检测不同饲养环境下的大鼠的体重、自发活动和足部电击敏感性。结果显示：与社群组相比，丰富组的大鼠条件化僵直水平明显增加，而贫瘠组的明显减少；丰富和贫瘠环境明显的影响了大鼠的体重；不同环境对自发活动和足部电击敏感性没有影响。这些结果说明幼年期的丰富环境能提高成年后大鼠的由声音诱发的条件化恐惧反应，而贫瘠环境则削弱了这种反应。
Posterolateral fusion for isthmic spondylolisthesis in adults: analysis of fusion rate and clinical results. (1998)

This is a retrospective study of 83 consecutive adult patients with isthmic spondylolisthesis who underwent identical decompressive surgery combined with posterolateral spine fusion. We sought to determine factors that affect the fusion rate and clinical outcomes for adult patients with isthmic spondylolisthesis. The outcome of operative treatment for isthmic spondylolisthesis in adults has been poorly documented, as opposed to the treatment of children and adolescents. From 1989 to 1994, 83 consecutive adult patients (age 19-66 years; average, 38 years) underwent surgical treatment consisting of the Gill procedure and posterolateral fusion for isthmic lumbosacral spondylolisthesis. Seventy-three patients (46 men and 27 women) were available for an average of 3.8 years' follow-up (1.0-7.4 years). Thirty-eight underwent one-level fusion, and 35 underwent two-level fusions. Pedicle screw instrumentation was performed in 69 patients. A postoperative questionnaire including the Roland index, clinical charts, and radiographs were reviewed by an independent observer to assess the postoperative course, clinical results, and fusion status. Twenty-five variables were evaluated to determine which affected the fusion and success rates. Primary radiologic fusion and clinical success rates were 78 and 71%, respectively. There was a strong positive correlation between radiologic fusion and clinical success. Overall, single-level fusions showed an 82% fusion rate, and two-level fusions, a 74% rate. For two-level fusions, a significantly higher fusion rate was achieved with a rigid pedicle screw-fixation system than a semirigid system (79 vs. 57%). For smokers, cessation from smoking postoperatively did not increase the fusion rate, and patients who continued to smoke after surgery showed a significantly higher rate of pseudarthrosis. Worker's compensation status did not affect clinical results significantly. Patients who continued to take nonsteroidal antiinflammatory drugs (NSAIDs) >3 months postoperatively showed significantly lower fusion and success rates (44 and 37%). Single-level lumbar fusion for isthmic spondylolisthesis was equally effective with either rigid or semirigid pedicle screw instrumentation. For multilevel spine fusion in isthmic spondylolisthesis, rigid pedicle screw-fixation systems resulted in a high fusion rate. A smoking history or NSAIDs use postoperatively had strong negative influences on the fusion and clinical success rates.
Carbohydrate epitopes currently recognized as targets for IgE antibodies (2021)

Until recently, glycan epitopes have not been documented by the WHO/IUIS Allergen Nomenclature Sub-Committee. This was in part due to scarce or incomplete information on these oligosaccharides, but also due to the widely held opinion that IgE to these epitopes had little or no relevance to allergic symptoms. Most IgE-binding glycans recognized up to 2008 were considered to be "classical" cross-reactive carbohydrate determinants (CCD) that occur in insects, some helminths and throughout the plant kingdom. Since 2008, the prevailing opinion on lack of clinical relevance of IgE-binding glycans has been subject to a reevaluation. This was because IgE specific for the mammalian disaccharide galactose-alpha-1,3-galactose (alpha-gal) was identified as a cause of delayed anaphylaxis to mammalian meat in the United States, an observation that has been confirmed by allergists in many parts of the world. Several experimental studies have shown that oligosaccharides with one or more terminal alpha-gal epitopes can be attached as a hapten to many different mammalian proteins or lipids. The classical CCDs also behave like haptens since they can be expressed on proteins from multiple species. This is the explanation for extensive in vitro cross-reactivity related to CCDs. Because of these developments, the Allergen Nomenclature Sub-Committee recently decided to include glycans as potentially allergenic epitopes in an adjunct section of its website (www.allergen.org). In this article, the features of the main glycan groups known to be involved in IgE recognition are revisited, and their characteristic structural, functional, and clinical features are discussed.
MiR-30a-5p suppresses tumor growth in colon carcinoma by targeting DTL (2012)

MicroRNAs (miRNAs) are small non-coding RNAs that are involved in different biological processes by suppressing target gene expression. Altered expression of miR-30a-5p has been reported in colon carcinoma. To elucidate its potential biological role in colon cancer, miR-30a-5p was overexpressed via a lentiviral vector system in two different colon cancer cell lines. This induced in both lines miR-30a-5p-mediated growth inhibition, attributable to a cell cycle arrest at the G(1) phase and an induction of apoptosis. Combining global gene expression analyses of miR-30a-5p transgenic line HCT116 with in silico miRNA target prediction, we identified the denticleless protein homolog (DTL) as a potential miRNA-30a-5p target. Subsequent reporter gene assays confirmed the predicted miR-30a-5p binding site in the 3'untranslated region of DTL. Importantly, overexpression of DTL in HCT116 cells partially rescued these cells from miR-30a-5p-mediated growth suppression. In addition, TP53 and CDKN1A expression were increased in miR-30a-5p-overexpressing HCT116 cells, suggesting that miR-30a-5p is able to modulate the cell cycle via a DTL-TP53-CDKN1A regulatory circuit. Finally, 379 colorectal cancer tissues were screened for DTL expression and DTL was found to be overexpressed in 95.8% of human colorectal cancers compared with normal colon mucosa. In conclusion, our data identified miR-30a-5p as a tumor-suppressing miRNA in colon cancer cells exerting its function via modulation of DTL expression, which is frequently overexpressed in colorectal cancer. Thus, our data suggest that restoring miR-30a-5p function may prove useful as therapeutic strategy for tumors with reduced miR-30a-5p expression.
Dirac Bracket Transformations in Phase Space (1955)

The purpose of this paper is twofold. One is to analyze the group-theoretical significance of the Dirac bracket and to examine, in particular, the apparent ambiguities in the presence of both first-class and second-class constraints. The other is to prepare the ground for the utilization of the Dirac bracket for the quantization of generally covariant theories. It is shown that the Dirac bracket represents the commutator of infinitesimal transformations in phase space which are not canonical but form a group, in that they are the only transformations that preserve the form of all the constraints of a theory as well as the canonical form of the equations of motion. This group of transformations possesses an invariant subgroup: those transformations that correspond to coordinate transformations, gauge transformations and the like.From this subgroup, we can construct the factor group. All members of the original group have generators, but the generators of the invariant subgroup are zero. There is, then, a one-to-one correspondence between the nonvanishing generators and the members of the factor group. The Dirac bracket is uniquely defined for all dynamical variables that can serve as generators; excluded are variables that have no invariant significance (such as the divergence of the electromagnetic vector potential). If it is possible to identify all these permissible generators, then the theory can be reformulated in terms of these and will be free of constraints. It is proposed to adopt the set of generators and the Dirac brackets between them as the point of departure for the formulation of covariant quantum theories.
P1018Evolution of atrioventricular conduction disorders after TAVI (2019)

Abstract Background The evolution of atrioventricular block (AVB) after Trans Aortic Valve Implantation (TAVI) is poorly understood, and indications of pacemaker (PM) implantation after TAVI not well defined. Modern PM algorithms can help studying the evolution of these AV conduction disorders after TAVI. SafeR® mode (Sorin® PM) allows to monitor precisely the AV conduction and to store AVB episodes in the PM memory as intracardiac electrograms, which can be re-read and validated afterwards. Methods From November 2015 and January 2017, all patients implanted in one of the 19 French enrolling centers with a Sorin® PM set in SafeR® mode after TAVI could be prospectively included in the study. All the PM interrogation files were centrally collected. The primary endpoint (PE) was the presence of at least one episode of high grade AVB (HG-AVB) beyond day 7 (D7) to one year after the TAVI. It could be validated either by the presence of a HG-AVB on EKG or telemetry, or by the confirmation of a HG-AVB in the PM memory files. Results 273 patients were included in the study, the PE was assessable in 197 patients. PE was validated in 74.6% patients. In univariate analysis, the use of an oversized prothesis or balloon, and all early episodes of HG-AVB (all those occurring up to D7) influence the validation of the PE. Other AV conduction disorders have no influence on the PE (Table). In multivariate analysis, only HG-AVB occurring between D2 and D7 has a significant influence on the PE. Factors influencing HG-AVB after TAVI Studied factor HG-AVB episode(s) during the one year follow up No HG-AVB episode during the one year follow up p value RBBB before TAVI (%) 41 34 0,346 Low implantation (&gt;6mm) (%) 59 37 0,156 Use of Autoexpansive Valve (%) 62 62 0,990 Oversizing (%) 19 6 0,022 HG-AVB per TAVI (%) 56 30 0,001 HG-AVB D0-D1 (%) 53 24 0,001 HG-AVB D2-D7 (%) 68 34 0,001 New or wiser LBBB and improvement of PR interval after TAVI (%) 30 39 0,253 Influence of predefined factors on the Primary Endpoint. Conclusion The analysis of the SafeR® algorithm files in patients implanted with a PM after TAVI show a high incidence of HG-AVB during the one year follow up. In multivariate analysis, only HG-AVB occurring between D2 and D7 significantly influence the PE, confirming that AV conduction disorders occurring during the first 24 hours may spontaneously normalize. Acknowledgement/Funding Microport CRM
Integrating Compressed Air Energy Storage (CAES) in Floating Offshore Wind Turbines (2019)

Abstract The design of an offshore energy storage system carries unknowns which need to be studied at an early stage of the project to avoid unnecessary costs of failures. These risks have led to an increasing dependence on more sophisticated mathematical models. This paper refers specifically to energy storage in the offshore wind farming industry and has the objective of proposing an adiabatic compressed air energy (A-CAES) system which would be integrated on a semi-submersible offshore wind turbine (OWT) platform. Calculations in respect to the sizing of the main sub-components of the system are included and estimates for the overall round trip efficiency are presented. Preliminary calculations to size the various parts of the energy storage system (ESS) have been carried out based on the energy availability of an offshore 8 MW wind turbine with real wind data from the North Sea. The load data to determine the lowest 12-hour demand period was taken from the Nordpool database. The calculations of the proposed conceptual design are based on an operational scenario in which the 24-hour period of a particular day is split in a 12-hour charging and 12-hour discharging cycle. For charging, a 5-bank, 2-stage compressor train is used to pressurize a number of steel cylindrical vessels with compressed air. This is followed by a process in which the compressed air is discharged across 12 hours using a 2-bank, 2-stage expander turbine. The multiple compression banks enable a modular power delivery to the air storage vessels, with the number of compressors utilized varying subject to wind availability. The two stages allowed for the air to be cooled in between the stages using heat exchangers, transferring the heat of compression to a pressurized sea water circuit. The hot water would be stored in thermally insulated vessels at 350°C to heat the inlet expanding air in the discharge period. A 70 and 100 Bar charging scenarios, both with a cushion pressure (CP) in the air storage vessel (ASV) of 10 Bar at the end of the discharge cycle have been considered. Standard performance criteria are calculated such as compression and expansion ratios, inlet and outlet temperatures for the respective expansion and compression air streams and flow rates within the heat exchangers to come up with an indicative sizing proposal for the respective turbo machinery and storage vessels making up the system. Round trip efficiencies are also calculated. The study determined that a CAES system consisting of 9 compressed air storage vessels operating with a peak pressure of 100 Bar should meet the storage requirements. It is also estimated that the entire CAES system would require around 1082 m2 of deck area on the platform to accommodate the pressure vessels, the compressor and expander trains, the heat exchanger and the hot water storage vessel.
A Dynamic Routing System Based on the IN-Architecture (1994)

A DR (Dynamic Routine) system based on the IN architecture - named IN/DR - is presented. It is well suited for large nonhierarchical meshed networks. An RSF (Route Switching Function) is implemented in a switch called RSP (Route Switching Point), which may be physically identical with an SSP. If the primary route to the destination RSP is blocked, the RSP starts a query via the CCS7 to an external processor called RCP (Routine Control Point), which may be physically identical with an SCP. For each link within its domain, the RCP determines the link occupancy from the time intervals between previous overflowing calls. For a given call attempt, the RCP computes path costs for all allowed routes. The cost is defined in terms of the expectancy of the number of lost calls in the future under the assumption of a certain traffic distribution. The response of the RCP is either an extended "Connect"-message containing the optimised routine instruction or a conventional "Reject"-messagge. If the DR system contains several RCPs, each RCP shall broadcast its current link occupancy data to all other RCPs in update intervals of 10 sec. For this distribution, a satellite based transmission scheme is recommended. There is one central processor within the DR system named RMS (Routine Management System). The RMS uses destination specific traffic data and network configuration data to compute the tables used by the RCPs during call processing.
Semantic Transform: Weakly Supervised Semantic Inference for Relating Visual Attributes (2013)

Relative (comparative) attributes are promising for thematic ranking of visual entities, which also aids in recognition tasks. However, attribute rank learning often requires a substantial amount of relational supervision, which is highly tedious, and apparently impractical for real-world applications. In this paper, we introduce the Semantic Transform, which under minimal supervision, adaptively finds a semantic feature space along with a class ordering that is related in the best possible way. Such a semantic space is found for every attribute category. To relate the classes under weak supervision, the class ordering needs to be refined according to a cost function in an iterative procedure. This problem is ideally NP-hard, and we thus propose a constrained search tree formulation for the same. Driven by the adaptive semantic feature space representation, our model achieves the best results to date for all of the tasks of relative, absolute and zero-shot classification on two popular datasets.
Thromboinflammation in Brain Ischemia: Recent Updates and Future Perspectives (2022)

Despite decades of promising preclinical validation and clinical translation, ischemic stroke still remains as one of the leading causes of death and disability worldwide. Within its complex pathophysiological signatures, thrombosis and inflammation, that is, thromboinflammation, are highly interconnected processes leading to cerebral vessel occlusion, inflammatory responses, and severe neuronal damage following the ischemic event. Hence, we here review the most recent updates on thromboinflammatory-dependent mediators relevant after stroke focusing on recent discoveries on platelet modulation, a potential regulation of the innate and adaptive immune system in thromboinflammation, utterly providing a thorough up-to-date overview of all therapeutic approaches currently undergoing clinical trial.
Calcinosis Cutis Associated with Severe Atherosclerosis and Severe Calcific Aortic Stenosis: Case Report (2017)

Calcinosis cutis is a condition of accumulation of calcium salts within the dermis. We report a case in which Calcinosis cutis is combined with severe cardiac involvement. Our patient suffered from Calcinosis cutis for about 40 years. Except dermal symptoms she presents with severe diffuse cardiovascular calcification. These involve calcification of large and middle arteries (such as femoral arteries, superior mesenteric artery), diffuse severe coronary atherosclerosis, pronounced calcification and phlebitis of the leg veins and calcification of cardiac valves including severe aortic stenosis and calcified mitral valve. Calcinosis cutis is a condition of accumulation of calcium salts within the dermis. We are presenting a case of Calcinosis cutis, with special clinical presentations, with normal serum calcium and phosphorus levels.
The patient has severe calcific aortic stenosis, calcified mitral valve, diffuse severe coronary atherosclerosis, and other large vessels such as femoral artery and artery meseterica superior. And pronounced calcification and phlepitis the leg veins.
Generation of Functional Insulin-Producing Cells from Pluipotent Stem Cell-Derived Human Intestinal Tissue (2015)

Dedhia, Priya H. MD, PhD; Finkbeiner, Stacy R. PhD; Altheim, Christopher H.; Chen, Yi-Ju PhD; Stanger, Ben Z. MD, PhD; Wolforth, Janet B.; Teitelbaum, Daniel H. MD, FACS; Spence, Jason R. PhD Author Information