gebhart/patrepeval huggingface dataset:
<title>Algorithm development for online control of the ABL</title> (1999)

In optics, Zernike orthogonal polynomials are used as a basis set for the expansion of wavefront phases. Due to the atmospheric turbulence-induced stochastic nature of the underlying process involved, the spatial-temporal correlation functions of the Zernike polynomial phase expansion coefficients must be evaluated if adaptive optics is to be employed. In this paper, these correlation functions are developed using a layered atmospheric model and calculations for the first few low-order Zernike modes are performed. Using these correlation functions, an underlying linear dynamical system is identified. Within an acceptable error bound, the correlation functions of this system are representative of the calculated correlation functions. This syste, in turn, provides the basis for the employment of advanced control and estimation concepts in an adaptive optics system that is being developed for the ABL.
[The endocrinologist's viewpoint on the long-term treatment of asthma with steroids]. (1980)

The function of the pituitary-adrenal axis and the pathophysiology of iatrogenic hypercorticism with its clinical manifestations are described. The pathophysiology and clinical presentation of acute adrenal failure after withdrawal of steroid medication are also described. What the attitude of the physician confronted with the decision of giving steroids to an asthmatic patient should be is analysed, as well as the ways to administer steroid drugs in order to avoid as much as possible unwanted secondary effects.
xMSannotator: An R Package for Network-Based Annotation of High-Resolution Metabolomics Data (2016)

Improved analytical technologies and data extraction algorithms enable detection of >10 000 reproducible signals by liquid chromatography-high-resolution mass spectrometry, creating a bottleneck in chemical identification. In principle, measurement of more than one million chemicals would be possible if algorithms were available to facilitate utilization of the raw mass spectrometry data, especially low-abundance metabolites. Here we describe an automated computational framework to annotate ions for possible chemical identity using a multistage clustering algorithm in which metabolic pathway associations are used along with intensity profiles, retention time characteristics, mass defect, and isotope/adduct patterns. The algorithm uses high-resolution mass spectrometry data for a series of samples with common properties and publicly available chemical, metabolic, and environmental databases to assign confidence levels to annotation results. Evaluation results show that the algorithm achieves an F1-measure of 0.8 for a data set with known targets and is more robust than previously reported results for cases when database size is much greater than the actual number of metabolites. MS/MS evaluation of a set of randomly selected 210 metabolites annotated using xMSannotator in an untargeted metabolomics human data set shows that 80% of features with high or medium confidence scores have ion dissociation patterns consistent with the xMSannotator annotation. The algorithm has been incorporated into an R package, xMSannotator, which includes utilities for querying local or online databases such as ChemSpider, KEGG, HMDB, T3DB, and LipidMaps.
Results from the third LLL underground coal gasification experiment at Hoe Creek (1980)

A major objective of the US Energy Program is the development of processes to produce clean fuels from coal. Underground coal gasification is one of the most promising of these processes. If successful, underground coal gasification (UCG) would quadruple the proven reserves of the US coal. Cost for products produced from UCG are projected to be 65 to 75% of those from conventional coal conversion. Finally, UCG appears to possess environmental advantages since no mining is involved and there are less solid wastes produced. In this paper we describe results from the Hoe Creek No. 3 underground coal gasification test. The experiment employed a drilled channel between process wells spaced 130' apart. The drilled channel was enlarged by reverse combustion prior to forward gasification. The first week of forward gasification was carried out using air injection, during which 250 tons of coal were consumed yielding an average dry product gas heating value of 114 Btu/scf. Following this phase, steam and oxygen were injected (generally a 50-50 mixture) for 47 days, during which 3945 tons of coal were consumed at an average rate of 84 tons of coal per day and an average dry gas heating value of 217 Btu/scf. Themore » average gas composition during the steam-oxygen phase was 37% H/sub 2/, 5% CH/sub 4/, 11% CO, and 44% CO/sub 2/. Gas recovery was approximately 82% during the test, and the average thermochemical efficiency was near 65%.« less
Mechanisms and Synthetic Modulators of AHL-Dependent Gene Regulation (2010)

International audience
Elevated Normal Immunoglobulins and Stable M-Protein Levels in Multiple Myeloma Patients on Erythropoietin Treatment. (2007)

Abstract Recombinant human erythropoietin (rHuEPO) is a well-known treatment for anemia in multiple myeloma (MM) patients. We have previously reported that rHuEPO treatment was associated with prolonged survival of several patients suffering from advanced disease (Mittelman et al., 1997). Recently we have demonstrated that treatment of MM patients with rHuEPO is associated with significant improvements of certain immunological parameters and functions (Prutchi-Sagiv et al., 2006), mainly related to the cellular compartment. The objective of the present retrospective study was to determine whether rHuEPO treatment, in addition to its effects on the cellular immune compartment, also modulates the humoral arm of the immune system in MM patients. Medical charts of eighteen consecutive IgG and IgA MM patients were analyzed and the levels of normal immunoglobulins (Ig) and M-protein before and during rHuEPO treatment were recorded. We have found a significant increase in the levels of normal Ig (IgG, IgA and IgM) in response to rHuEPO, during the 3–9 months fromtreatment initiation. Importantly, the levels of M-protein remained stable for a period of 10–12 months from treatment initiation. These results are in line with previous studies, including our study in murine models (Katz et al., 2007), demonstrating that EPO improves humoral immune responses. The current study highlights the concept that EPO’s immunomodulatory actions on MM patients might also involve the humoral compartment of the immune system.
Use of a visual analog scale for evaluation of bother from pelvic organ prolapse (2013)

Quantification of prolapse bother using a visual analog scale is valid and repeatable and may represent a simple tool for use in clinical practice.
Towards Nucleotide Analogues with Metal Complexing Proprties. Synthesis of Dinucleoside Terpyridyl- and Bipyridylphosphonates (2004)

Towards Nucleotide Analogues with Metal Complexing Proprties. Synthesis of Dinucleoside Terpyridyl- and Bipyridylphosphonates
Resistance of adhered bacteria to rigid gas permeable contact lens solutions. (1995)

We examined eight conditioning or disinfecting solutions recommended for use with rigid gas permeable (RGP) or hard contact lenses for their efficacy against planktonic and attached cells of bacteria and Candida albicans. Most solutions, particularly those containing phenylmercuric nitrate and polyaminopropyl biguanide, gave marked inhibition (99.99% reduction within 4 hours) of planktonic cells of bacteria. Planktonic cells of Serratia marcescens and C. albicans survived in certain solutions containing chlorhexidine and benzalkonium chloride. In contrast, cells of all test microorganisms adhered to wells of polyethylene contact lens cases showed various degrees of survival after 4, 6, and 12 hours of exposure to most contact lens solutions. Drying of the lens case with adhered cells for 10 hours prior to addition of the lens solution usually reduced the incidence of recovery. Studies demonstrated that biofilms developed in cases with solutions of low and high efficacy. The enhanced resistance of adhered cells requires the periodic disinfection or replacement of lens cases used with RGP lenses.
Mooring Dynamics Phenomena Due to Slowly-Varying Wave Drift (2004)

The effects of slowly varying wave drift forces on the nonlinear dynamics of mooring systems have been studied extensively in the past 30 years. It has been concluded that slowly varying wave drift may resonate with mooring system natural frequencies. In recent work, we have shown that this resonance phenomenon is only one of several possible nonlinear dynamic responses of mooring systems to slowly varying wave drift excitation. We were able to reveal new phenomena based on the design methodology developed at the University of Michigan for autonomous mooring systems and treating slowly varying drift as an external time-varying force. In this paper, the U of M methodology is used systematically to reveal seven phenomena induced by mean and slowly varying drift forces; one of those is resonance. Conceptually, numerous qualitatively different behaviors may be induced. The next step toward the comprehensive identification of such phenomena is taken by introducing the method of harmonic balance to study nonautonomous mooring systems.
Opium (2016)

Abstract Opium is a drug that has had transformative effects on politics, cultures, and economies in Asia and Europe. Since the late eighteenth century, opium has been inextricable from imperialism, as Indian opium revenues helped fund the maintenance of the British Empire in India, and opium contributed to two wars between Britain and China and the subsequent significant shift in the balance of power between the two countries. In the twentieth century, the international consensus came to favor the eradication of the opium industry, though colonial powers with an interest in its continuance opposed this consensus. Despite international attempts to regulate sales and consumption of this drug, opium cultivation continues in the Golden Triangle region of Southeast Asia and in Afghanistan.
Study of the Surface Chemistry of Modified Carbon Nanofibers by Oxidation Treatments in Liquid Phase (2009)

Carbon nanofibers (CNF) were grown by thermocatalytic decomposition of methane. Their texture and surface chemistry were modified by different oxidation treatments with HNO3 at different concentrations or a mixture of HNO3-H2SO4 to optimise their ability of dispersing active metal particles, because this material will be used as electrocatalytic support for polymeric electrolyte fuel cells. The effect of liquid phase oxidation on the surface chemistry and the textural properties of the CNF was studied by temperature programmed desorption (TPD), scanning electron microscopy (SEM) and N2-physisorption. Moreover, their thermal stability was studied by temperature programmed oxidation (TPO). During oxidation treatments functional groups were created and their number was function of the oxidation treatment conditions. Results indicated that an increase in severity of the oxidation treatment produces an increase in the number of surface oxygen groups and in the thermal stability. However, a very severe treatment can destroy partially the structure of carbon nanofibers.
SGI-110. DNA methyltransferase inhibitor, Oncolytic (2013)

SGI-110 is a second-generation hypomethylating prodrug whose active metabolite is the well-characterized drug decitabine. This novel compound is an oligonucleotide consisting of decitabine linked through a phosphodiester bond to the endogenous nucleoside deoxyguanosine. The dinucleotide configuration provides protection from drug clearance by deamination, while maintaining at least equivalent effects on gene-specific and global hypomethylation both in vitro and in animal model systems. This agent is currently being tested in phase I and II clinical trials in humans and has been demonstrated to be safe and well tolerated as a single agent, with evidence of promising activity in heavily pretreated (including currently FDA approved hypomethylating drugs) myelodysplastic syndrome and acute myeloid leukemia patients. Ongoing trials are also open in platinum-resistant ovarian cancer and hepatocellular carcinoma.
Monitoring pH and ORP in a SHARON reactor (2011)

This paper analyses the valuable information provided by the on-line measurements of pH and oxidation reduction potential (ORP) in a continuous single high ammonia removal over nitrite (SHARON) reactor. A laboratory-scale SHARON reactor equipped with pH, ORP, electric conductivity and dissolved oxygen (DO) probes has been operated for more than one year. Nitrogen removal over nitrite has been achieved by adding methanol at the beginning of anoxic stages. Time evolution of pH and ORP along each cycle allows identifying the decrease in nitritation rate when ammonia is consumed during the aerobic phase and the end of the denitrification process during the anoxic phase. Therefore, monitoring pH and ORP can be used to develop a real-time control system aimed at optimizing the length of both aerobic and anoxic stages. Real-time control of methanol addition can be carried out by using the information provided by these probes: excessive methanol addition in the anoxic stage is clearly detected in the ORP profile of the following aerobic phase, while a deficit of methanol is detected in both pH and ORP profiles of that anoxic phase. Moreover, other valuable information such as the amount of ammonia nitrified, failures in DO measurements, excessive stirring during the anoxic stage and methanol dosage in the aerobic phase was also provided by the pH and ORP profiles.
Rapid 3D Printing of Electrohydraulic (HASEL) Tentacle Actuators (2020)

Abstract A comprehensive material system is introduced for the additive manufacturing of electrohydraulic (HASEL) tentacle actuators. This material system consists of a photo‐curable, elastomeric silicone‐urethane with relatively strong dielectric properties (ε r ≈ 8.8 at 1 kHz) in combination with ionically‐conductive hydrogel and silver paint electrodes that displace a vegetable‐based liquid dielectric under the application of an electric field. The electronic properties of the silicone material as well as the mechanical properties of the constitutive silicone and hydrogel materials are investigated. The hydraulic pressure exerted on the dielectric working fluid in these capacitive actuators is measured in order to characterize their quasi‐static behavior. Various design features enabled by 3D printing influence this behavior—decreasing the voltage at which actuation begins or increasing the force density in the system. Using a capacitance change of &gt;35% across the actuators while powered, a demonstration of self‐sensing inherent to HASELs is shown. Antagonistic pairs of the 3D printed actuators are shown to exert a blocked force of over 400 mN. An electrohydraulic tentacle actuator is then fabricated to demonstrate the use of this material and actuation system in a synthetic hydrostat. This tentacle actuator is shown to achieve motion in a multi‐dimensional space.
SEAPI QMM incontinence classification system (1992)

Abstract Outcome of therapy for many incontinent patients is persistently difficult to assess in spite of a large published literature. One problem is that each institution describes patient populations and outcomes based on its own system, thus, valid comparisons between institutions cannot be made. To help to resolve this problem we are proposing a standardized classification system for incontinence. The system is analogous to the TNM system for tumor staging. Each letter of SEAPI QMM represents an aspect of incontinence, and each factor is assigned a number grade. Zero represents no symptom, problem, or abnormality while 1, 2, and 3 represent mild, moderate, or severe problems, respectively. This proposed system does not cover every aspect of urinary incontinence, however it can be used as a base for further development of a uniform method to grade and stage urinary incontinence. © 1992 Wiley‐Liss, Inc.
ChemInform Abstract: RK. VON NITROMETHAN MIT HEXAFLUORBENZOL BEI 550 GRAD (1972)

Abstract Die gemeinsame Pyrolyse von Hexafluorbenzol (I) und Nitromethan (II) bei 550°C führt u.a. zu den Reaktionsprodukten (III)‐(IX).
Interaction between Autonomous and Microtubule Guidance Systems Controls Cellulose Synthase Trajectories (2020)

The organization of cellulose microfibrils is critical for the strength and growth of plant cell walls. Microtubules have been shown to play a key role in controlling microfibril organization by guiding cellulose synthase complexes [1-4]. However, cellulose synthase trajectories can be maintained when microtubules are removed by drugs, suggesting a separate guidance mechanism is also at play [1, 5, 6]. By slowing down microtubule dynamics, we reveal such a mechanism by showing that cellulose synthase complexes can interact with the trails left by other complexes, causing them to follow the trails or disappear. The stability of the trails, together with the sensitivity of their directions to cellulase treatment, indicates they most likely reflect nascent cellulose microfibrils. Over many hours, this autonomous mechanism alone can lead to a change in the dominant orientation of cellulose synthase trajectories. However, the mechanism can be overridden by the microtubule guidance system. Our findings suggest a dual guidance model, in which an autonomous system, involving interaction between cellulose synthases and microfibrils, can maintain aligned cellulose synthase trajectories, while a microtubule guidance system allows alignments to be steered by environmental and developmental cues.
Reducing Residual Stress in 7050 Aluminum Alloy Die Forgings by Heat Treatment (2008)

Aerospace aluminum alloy forgings can have the residual stresses arising from heat treatment reduced by modification to the quench cooling rates and subsequent aging treatments. A series of propeller hubs usually made from the alloy 2014 have been closed die forged from the less quench sensitive alloy 7050. These forgings have been subjected to various quenching and aging treatments in an attempt to improve the balance of mechanical properties with the residual stress magnitudes. These forgings were not amenable to stress relieving by cold compression or stretching. Warm water (60°C) and boiling water quenches are investigated in addition to quenching into molten salt (200°C) and uphill quenching from −196°C. Various dual aging treatments including retrogression and reaging have been evaluated in an attempt to optimize low residual stress magnitudes with mechanical properties. Residual stresses determined by the center hole-drilling strain-gauge method are reported in addition to electrical conductivity, stress corrosion cracking, fracture toughness, initiation fatigue, and tensile mechanical property variations. It was found that quenching into boiling water and salt at 200°C did substantially reduce the residual stress but had only a small detrimental effect on the majority of the properties measured. However, the influence of quench rate on fracture toughness was much more significant. This is attributed to both coarse grain boundary precipitation and heterogeneous precipitation of η on Al3Zr dispersoids within the grains, which promotes easier crack propagation.
A Small But Non-negligible Flaw in the Android Permission Scheme (2010)

This paper presents a flaw in the permission scheme of Android. The Android framework enforces a permission-based security policy where an application can access the other parts of the system only when the application is explicitly permitted. The security of the framework depends to a large extent on the owner of a device since the authorization decisions are mainly made by the user. As a result, the permission scheme imposes much of the administrative burden on the user instead of keeping it simple. Moreover, the framework does not impose enough controls nor support dynamic adjustment in the following respects: No naming rule or constraint is applied for a new permission declaration; once an application acquires a permission, the permission is never revoked during the lifetime of the application, two different permissions can be in use having the same name. These features of the framework can result in a security flaw. We explain how we found the flaw, demonstrate an exploit example, and discuss the solution.
Preparation and spectroscopic properties of cobalt(III) complexes containing phosphine ligands. The electronic structural description of side-bonded dioxygen (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and spectroscopic properties of cobalt(III) complexes containing phosphine ligands. The electronic structural description of side-bonded dioxygenVincent M. Miskowski, John L. Robbins, George S. Hammond, and Harry B. GrayCite this: J. Am. Chem. Soc. 1976, 98, 9, 2477–2483Publication Date (Print):April 1, 1976Publication History Published online1 May 2002Published inissue 1 April 1976https://pubs.acs.org/doi/10.1021/ja00425a015https://doi.org/10.1021/ja00425a015research-articleACS PublicationsRequest reuse permissionsArticle Views325Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts