gebhart/patrepeval huggingface dataset:
Aesthetic Abstracts (2022)

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A STUDY OF SURGICAL THERAPY FOR RECURRENCES AFTER RESECTION OF LIVER METASTASES FROM COLORECTAL CANCER (1999)

This study of 43 cases of curative hepatectomy for colorectal metastases over the past 15 years in our institution reports an analysis of resectable rate, morbidity, mortality, survival rate, and quality of life (QOL) of surgical therapy for recurrences after hepatectomy. Recurrence was seen in 25 patients: hepatic recurrences in 20 patients, pulmonary recurrences in nine, peritoneal dissemination in six, lymph node metastasis in three, pleural dissemination in two, local recurrences of abdominal wall in two, and bone metastasis, brain metastasis, intrapelvic recurrence in one patient each. We performed repeated hepatectomy nine times for six patients, pulmonary resection five times for three patients, and abdominal wall resection one time for one patient. During repeated hepatectomy, pulmonary metastases were resected in two patients. The median duration of postoperative admission for all 13 operations for seven recurrent patients was 15 days and there was no morbidity or mortality. There was no case of death within six months and the five-year survival rate was 71%. All patients were able to return to their normal lives. Repeated resection of recurrences after hepatectomy is shown to achieve a short hospital stay, early recovery of QOL, and an excellent survival rate. We conclude that repeated surgical therapy is an adequate procedure for recurrent metastases from colorectal cancer.
Analysis of genes upregulated by the demethylating agent 5‐aza‐2′‐deoxycytidine in gastric cancer cell lines (2006)

In gastric cancer, increasing numbers of genes have been reported to be silenced by aberrant methylation. However, global analysis of epigenetic inactivation in cancer cells has rarely been performed. For screening the genes upregulated by the demethylating agent 5-aza-2'-deoxycytidine (DAC), cDNA microarray analysis (AceGene(R), containing 30,000 genes) was performed using gastric cancer cell lines (AGS, MKN74, MKN1, MKN45 and Kato3) treated with DAC. The candidate upregulated genes were confirmed by real-time PCR, and the methylation status of 5'CpG islands was determined by bisulfite DNA sequencing or methylation-specific PCR. Among the upregulated genes considered to have CpG island in their promoter regions, we selected 5 genes (BCL2L10, DKK1, DNAJD1, GAGED2 and NMU) that exhibited a greater than 3-fold increase in at least 2 cell lines. Of these, we could determine the methylation status of 5'CpG islands of BCL2L10, DKK1 and DNAJD1. 5'CpG of BCL2L10 and DNAJD1 was hypermethylated in 4 of 5 gastric cancer cell lines, whereas 5'CpG of DKK1 was hypermethylated in only 1 cell line. MSP analysis for BCL2L10 revealed that the CpG island was demethylated after DAC treatment. In addition, we observed that overexpression of BCL2L10 could promote apoptosis and growth-inhibitory effect in gastric cancer cell lines. In conclusion, some of the genes upregulated by DAC treatment may be transcriptionally repressed by promoter hypermethylation. These genes might be related to gastric carcinogenesis. In particular, the suppression of BCL2L10, which could induce apoptosis and inhibit proliferation of cancer cells, might be one of the underlying mechanisms for gastric carcinogenesis.
MATHEMATICAL MORPHOLOGY EXERCISES With MAMBA (Release 1) (2014)

Exercises book in mathematical morphology using the Mamba software library (This release does not contain solutions).
Clinicopathologic and Genetic Characterization of Traditional Serrated Adenomas of the Colon (2012)

Traditional serrated adenomas (TSAs) are a type of colorectal polyp with neoplastic potential. Immunohistochemical analysis and sequencing were performed on 24 TSAs from 23 patients to characterize the molecular genetics of TSAs. Abnormal Ki-67 and p53 labeling were observed in 7 (29%) of 24 and 6 (25%) of 24 TSAs, respectively; both types were significantly associated with the presence of conventional epithelial dysplasia (P = .0005 and P = .0001, respectively). Activating KRAS mutation was identified in 11 TSAs (46%) and was mutually exclusive with activating BRAF mutations, which were seen in 7 TSAs (29%). Abnormal p53 nuclear labeling in a TSA was significantly associated with BRAF mutation status (P = .04), whereas no relationship was found for β-catenin labeling patterns. The overall morphologic features of TSA do not correlate with the genetic status of the KRAS and BRAF genes. However, conventional epithelial dysplasia and abnormal p53 labeling in a TSA are seen more often in the setting of BRAF mutation.
Decrease of postprandial endothelial dysfunction by spice mix added to high‐fat hamburger meat in men with Type 2 diabetes mellitus (2013)

Adding a spice mix to hamburger meat prior to cooking resulted in a reduction in urinary malondialdehyde, an increase in urinary nitrate/nitrite and improvement of postprandial endothelial dysfunction in men with Type 2 diabetes. Therefore, cooking a hamburger with a polyphenol-rich spice mixture may lead to potential cardiovascular benefits in patients with Type 2 diabetes mellitus.
Cu Mixed Oxides Based on Hydrotalcite-Like Compounds for the Oxidation of Trichloroethylene (2013)

Different Cu/(Mg or Ni)/Al mixed oxides based on hydrotalcite-like compounds have been studied for the catalytic oxidation of trichloroethylene. The catalysts have been synthesized and characterized by different techniques such as N2-adsorption, inductively coupled plasma (ICP), X-ray diffraction, and temperature-programmed reduction (TPR). It has been shown that the activity for the catalytic abatement of trichloroethylene depends on the presence of metals with redox properties in the catalyst composition. The best results have been obtained with containing copper mixed oxides, although there is no direct correspondence between the copper content and the catalyst activity. These catalysts are highly active and selective, CO2 and HCl being the main reaction products. A mechanism for the reaction has been proposed.
Molecular Links Between Obesity and Cardiovascular Disease (2002)

Obesity is a recognized risk factor for cardiovascular disease. Because the prevalence of obesity is rising in industrialized as well as developing nations, it is important to understand the mechanisms by which obesity targets the vascular system. A metabolic syndrome of insulin resistance is provoked by obesity, and this results in the dysregulation of a number of adipocyte-derived factors, which favors atherosclerosis. This review focuses on how products of the adipocyte, including free fatty acids and “adipo”-cytokines, may mediate the effect of obesity on insulin resistance and atherosclerosis.
Generative Adversarial Network Based Multi-class Imbalanced Fault Diagnosis of Rolling Bearing (2019)

Fault diagnosis of rolling bearing plays an important role for the assessment of system reliability. Meanwhile, the number of fault data tend to be much less than the normal data in the real application. This imbalanced problem will greatly reduce the accuracy of most traditional fault diagnosis methods. Especially for the multi-classification problem, some conventional methods can not have good performance on dealing with unbalanced data. In this paper, a method based on generative adversarial network network which generates data for data unbalanced compensation is proposed. This method use designed generator to generate the virtual data which has significant useful features to puzzle the discriminator. Moreover, the virtual data that out-trick the discriminator can be added into the minor dataset. Finally, the classifier based on Convolutional Neurtal Network will dispose the new dataset. In order to verify the effect of this method, experiments based on major methods and proposed method are executed on the CWRU bearing dataset under different loads, which will reduce the correlation of data over time continuity in order to achieve a more realistic fit. Moreover, the proposed method has been compared with several widely applied methods for imbalanced data in fault diagnosis in terms of accuracy. Finally, the comparative results demonstrate that the proposed method has better performance on dealing with the imbalanced problem in fault diagnosis of the rolling bearing than major methods.
Abstract B105: Ganetespib, a unique resorcinolic Hsp90 inhibitor, exhibits potent antitumor activity and a superior safety profile in preclinical models. (2011)

Abstract Targeted inhibition of the molecular chaperone heat shock protein 90 (Hsp90) results in the simultaneous blockade of multiple oncogenic signaling pathways and has thus emerged as an attractive strategy for the development of novel cancer therapeutics. Ganetespib (STA-9090) is a unique resorcinolic inhibitor of Hsp90 currently in clinical trials for a number of human cancers. Here we describe the key interaction of ganetespib with a number of amino acid residues in the ATP binding pocket of Hsp90 which results in high affinity binding. Ganetespib exhibits potent in vitro cytotoxicity in a range of solid and hematological tumor cell lines. By using a novel isotope-labeling scheme and LC-MS/MS detection technique, we have determined that Hsp90 occupancy by ganetespib in cancer cells is relatively fast under saturating conditions, reaching equilibrium within 5 minutes of ganetespib exposure. In vivo, ganetespib demonstrated strong single-agent activity in solid and hematological xenograft models, as evidenced by significant tumor growth inhibition and/or regression. Of note, evaluation of the microregional activity of ganetespib in tumor xenografts showed that ganetespib efficiently distributed throughout tumor tissue, including hypoxic regions &amp;gt;150 m from the microvasculature, to inhibit proliferation and induce apoptosis. Most importantly, ganetespib showed no evidence of cardiac or liver toxicity and exhibited minimal potential risk for CNS or ocular toxicities. Taken together, this preclinical activity profile suggests that ganetespib may have broad application for a variety of human malignancies and mechanistic and safety advantages over other first- and second-generation Hsp90 inhibitors. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2011 Nov 12-16; San Francisco, CA. Philadelphia (PA): AACR; Mol Cancer Ther 2011;10(11 Suppl):Abstract nr B105.
Functional assessment of a washing emulsion for sensitive skin: mild impairment of stratum corneum hydration, pH, barrier function, lipid content, integrity and cohesion in a controlled washing test (2005)

The investigated standardized washing model with the endpoints epidermal barrier function, SC hydration, surface pH, skin surface lipids, skin temperature and SC integrity/cohesion showed only mild damage comparable to washing with water.
patible Tungsten Heater (2012)

We present a Tungsten thermo-opti using standard CMOS back-end fabrication p efficiency of 35.2mW/FSR was achieved on rin 10%-90% heating time of 2.8µs. Keywords - Silicon photonics, thermo-optic Integration
Migratory compression: coarse-grained data reordering to improve compressibility (2014)

We propose Migratory Compression (MC), a coarse-grained data transformation, to improve the effectiveness of traditional compressors in modern storage systems. In MC, similar data chunks are re-located together, to improve compression factors. After decompression, migrated chunks return to their previous locations. We evaluate the compression effectiveness and overhead of MC, explore reorganization approaches on a variety of datasets, and present a prototype implementation of MC in a commercial deduplicating file system. We also compare MC to the more established technique of delta compression, which is significantly more complex to implement within file systems.We find that Migratory Compression improves compression effectiveness compared to traditional compressors, by 11% to 105%, with relatively low impact on run-time performance. Frequently, adding MC to a relatively fast compressor like gzip results in compression that is more effective in both space and runtime than slower alternatives. In archival migration, MC improves gzip compression by 44-157%. Most importantly, MC can be implemented in broadly used, modern file systems.
Evidence for a dominant role of lipoxygenase(s) in the oxidation of LDL by mouse peritoneal macrophages (1991)

It has been suggested that the oxidative modification of low density lipoprotein (LDL) is a key event in atherogenesis. Several mechanisms have been proposed to explain how different types of cells modify LDL. In this study we examine the relative contributions of superoxide anions and cellular lipoxygenase (LO) in the modification of LDL by macrophages. Superoxide dismutase (SOD) inhibited LDL oxidation by macrophages but only by 25%. Under the same conditions, several LO inhibitors (eicosatetraynoic acid (ETYA), piriprost, and A-64077) almost completely inhibited the modification of LDL by macrophages. SOD had a greater inhibitory effect on the modification of LDL by U937 cells and fibroblasts (32% and 64%, respectively) but again LO inhibitors had a much greater effect (79 to 100% inhibition). Incubation of [1-14C]linoleic acid with mouse peritoneal macrophages resulted in its conversion to a single more polar product coeluting with 13- and 9-HODE by reverse phase HPLC. When the cells were preincubated with LO inhibitors, formation of this product was significantly inhibited. It is concluded that the modification of LDL by macrophages is mediated in large part by lipoxygenase-type activity.
Spatial and Temporal Control of Thiol-Michael Addition via Photocaged Superbase in Photopatterning and Two-Stage Polymer Networks Formation (2014)

Photochemical processes enable spatial and temporal control of reactions, which can be implemented as an accurate external control approach in both polymer synthesis and materials applications. "Click" reactions have also been employed as efficient tools in the same field. Herein, we combined photochemical processes and thiol-Michael "click" reactions to achieve a "photo-click" reaction that can be used in surface patterning and controlled polymer network formation, owing to the ease of spatial and temporal control through use of photolabile amines as appropriate catalysts.
Deterministic enhancement of coherent photon generation from a nitrogen-vacancy center in ultrapure diamond (Conference Presentation) (2017)

A key requirement for many applications in solid-state quantum sciences is a high fluence of indistinguishable photons. The spontaneous emission of these photons is governed by the coupling of an excited quantum system to electromagnetic vacuum fluctuations. In our experiment, we enhance this coupling by engineering a tunable Fabry-Perot microcavity. The quantum system we study is the nitrogen-vacancy (NV) center in diamond, a workhorse for quantum science and engineering, due to its optical transitions and the coherent electron spin system it hosts. Our device consists of a high-quality, nano-fabricated, single-crystalline diamond membrane bonded to a planar mirror; the cavity is completed by a second, concave mirror. Using piezo positioners, we achieve full spectral and spatial tunability and freedom in selecting NVs with favorable emission properties in our low-temperature (4 Kelvin) experiments. Upon tuning of the cavity into resonance, we find significant enhancement of the 637 nm zero phonon line for several individual NVs which is accompanied by a strong reduction of the overall photoluminescence (PL) lifetime. We infer a 30-fold enhancement of the zero-phonon transition rate at best. The fraction of the PL emission associated to this resonant transition is thereby increased from 3% to 46%. Our results constitute a significant leap on the route towards the implementation of fast long-distance quantum networks, which are currently limited by the photon emission rate in their nodes. Furthermore, our versatile design is readily applicable to other solid-state quantum emitters like color centers in silicon carbide.
Parametric Excitation of Ion-Acoustic Waves in a Bounded Plasma (1971)

Parametric excitation of ion-acoustic waves is demonstrated in a Q machine by modulating the electron temperature. The results agree with an analysis based on the Mathieu equation.
Responses of Anabaena sp. PCC7120 to lindane: Physiological effects and differential expression of potential lin genes (2023)

Lindane (γ-HCH) is an organochlorine pesticide that causes huge environmental concerns worldwide due to its recalcitrance and toxicity. The use of the cyanobacterium Anabaena sp. PCC 7120 in aquatic lindane bioremediation has been suggested but information relative to this process is scarce. In the present work, data relative to the growth, pigment composition, photosynthetic/respiration rate, and oxidative stress response of Anabaena sp. PCC 7120 in the presence of lindane at its solubility limit in water are shown. In addition, lindane degradation experiments revealed almost a total disappearance of lindane in the supernatants of Anabaena sp. PCC 7120 culture after 6 days of incubation. The diminishing in lindane concentration was in concordance with an increase in the levels of trichlorobenzene inside the cells. Furthermore, to identify potential orthologs of the linA, linB, linC, linD, linE, and linR genes from Sphingomonas paucimobilis B90A in Anabaena sp. PCC 7120, a whole genome screening was performed allowing the identification of five putative lin orthologs (all1353 and all0193 putative orthologs of linB, all3836 putative orthologs of linC, and all0352 and alr0353 putative orthologs of linE and linR, respectively) which could be involved in the lindane degradation pathway. Differential expression analysis of these genes in the presence of lindane revealed strong upregulation of one of the potential lin genes of Anabaena sp. PCC 7120.
Estimating the lower explosive limits of waste vapors (1995)

The authors report the results of a survey on the efficacy against mosquito bites of a repellent, Mousticologne Spécial Zones Infestées (DEET 20%, EHD 15%). Two forms of the product, spray and gel, were tested in Senegal. Repellent efficacy was evaluated by exposing volunteers, both repellent-treated and untreated, to mosquito bites. The number of mosquito bites per person and per night was 0.63 in the spray treated group (group 1), 6.03 in the gel treated group (group 2) and 94.17 in the untreated group (group 3). The analysis of these results showed a significant difference between treated and untreated persons. Untreated persons were not protected against mosquito bites, persons treated with the spray were protected for 12 hours and those treated with the gel had over 8 hours' protection. We concluded that a single application of the repellent Mousticologne in the field is capable of ensuring all-night protection against mosquito bites.
Damage Assessment of Composite Honeycomb Material Using Advanced Inspection Technologies. (2012)

Abstract not provided.
Polarization independent InP-based space switch with double-etched waveguide structure (1999)

Optical space switches play a key role in advanced optical networks, both for WDM and single wavelength applications. Besides low crosstalk, low loss and polarization independence an important requirement for these switches is small size.
GES-2, a Class A β-Lactamase from Pseudomonas aeruginosa with Increased Hydrolysis of Imipenem (2001)

Pseudomonas aeruginosa GW-1 was isolated in 2000 in South Africa from blood cultures of a 38-year-old female who developed nosocomial pneumonia. This isolate harbored a self-transferable ca. 100-kb plasmid that conferred an expanded-spectrum cephalosporin resistance profile associated with an intermediate susceptibility to imipenem. A beta-lactamase gene, bla(GES-2), was cloned from whole-cell DNA of P. aeruginosa GW-1 and expressed in Escherichia coli. GES-2, with a pI value of 5.8, hydrolyzed expanded-spectrum cephalosporins, and its substrate profile was extended to include imipenem compared to that of GES-1, identified previously in Klebsiella pneumoniae. GES-2 activity was less inhibited by clavulanic acid, tazobactam and imipenem than GES-1. The GES-2 amino acid sequence differs from that of GES-1 by a glycine-to-asparagine substitution in position 170 located in the omega loop of Ambler class A enzymes. This amino acid change may explain the extension of the substrate profile of the plasmid-encoded beta-lactamase GES-2.
You Too?! Mixed-Initiative LDA Story Matching to Help Teens in Distress (2021)

Adolescent cyber-bullying on social networks is a phenomenon that has received widespread attention. Recent work by sociologists has examined this phenomenon under the larger context of teenage drama and it's manifestations on social networks. Tackling cyber-bullying involves two key components – automatic detection of possible cases, and interaction strategies that encourage reflection and emotional support. Key is showing distressed teenagers that they are not alone in their plight. Conventional topic spotting and document classification into labels like "dating" or "sports" are not enough to effectively match stories for this task. In this work, we examine a corpus of 5500 stories from distressed teenagers from a major youth social network. We combine Latent Dirichlet Allocation and human interpretation of its output using principles from sociolinguistics to extract high-level themes in the stories and use them to match new stories to similar ones. A user evaluation of the story matching shows that theme-based retrieval does a better job of finding relevant and effective stories for this application than conventional approaches.
Faculty Opinions recommendation of Integrin alpha4beta1-VCAM-1-mediated adhesion between endothelial and mural cells is required for blood vessel maturation. (2005)

Neovascularization depends on vascular cell proliferation and on the stabilization of vessels by association of vascular smooth muscle-like pericytes with ECs. Here we show that integrin alpha4beta1 (VLA-4) and VCAM-1 promote close intercellular adhesion between ECs and pericytes and that this interaction is required for blood vessel formation. Integrin alpha4beta1 is expressed by proliferating but not quiescent ECs, while its ligand VCAM-1 is expressed by proliferating but not quiescent mural cells. Antagonists of this integrin-ligand pair block the adhesion of mural cells to proliferating endothelia in vitro and in vivo, thereby inducing apoptosis of ECs and pericytes and inhibiting neovascularization. These studies indicate that integrin alpha4beta1 and VCAM-1 facilitate a critical cell-cell adhesion event required for survival of endothelial and mural cells during vascularization. PMID: 15902308