gebhart/patrepeval huggingface dataset:
Voice Filter: Few-Shot Text-to-Speech Speaker Adaptation Using Voice Conversion as a Post-Processing Module (2022)

State-of-the-art text-to-speech (TTS) systems require several hours of recorded speech data to generate high-quality synthetic speech. When using reduced amounts of training data, standard TTS models suffer from speech quality and intelligibility degradations, making training low-resource TTS systems problematic. In this paper, we propose a novel extremely low-resource TTS method called Voice Filter that uses as little as one minute of speech from a target speaker. It uses voice conversion (VC) as a post-processing module appended to a pre-existing high-quality TTS system and marks a conceptual shift in the existing TTS paradigm, framing the few-shot TTS problem as a VC task. Furthermore, we propose to use a duration-controllable TTS system to create a parallel speech corpus to facilitate the VC task. Results show that the Voice Filter outperforms state-of-the-art few-shot speech synthesis techniques in terms of objective and subjective metrics on one minute of speech on a diverse set of voices, while being competitive against a TTS model built on 30 times more data. <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup>
Robust Mesh Data Hiding Based On Irregular Wavelet Transform (2012)

Publication in the conference proceedings of EUSIPCO, Bucharest, Romania, 2012
Deregulation of microRNA expression in follicular cell-derived human thyroid carcinomas (2009)

Carcinoma of the thyroid gland is an uncommon cancer, but one of the most frequent malignancies of the endocrine system. Most thyroid cancers are derived from the follicular cells. Follicular carcinoma is considered more malignant than papillary thyroid carcinoma (PTC), and anaplastic thyroid cancer (ATC) is one of the most lethal human cancers. Even though several genetic lesions have been already described in human thyroid cancer, particularly in the papillary histotype, the mechanisms underlying the development of these neoplasias are still far from being completely elucidated. Some years ago, several studies were undertaken to analyze the expression of microRNAs (miRNAs or miRs) in thyroid carcinoma to evaluate a possible role of their deregulation in the process of carcinogenesis. These studies showed an aberrant microRNA expression profile that distinguishes unequivocally among PTC, ATC, and normal thyroid tissue. Here, other than summarizing the current findings on microRNA expression in human thyroid carcinomas, we discuss the mechanisms by which microRNA deregulation may play a role in thyroid carcinogenesis, and the possible use of microRNA knowledge in the diagnosis and therapy of thyroid neoplasms.
ADVANCES IN MAGNETICS 1747 A Homogenized Energy Framework for Ferromagnetic Hysteresis (2006)

In this paper, we develop a macroscopic framework quantifying the hysteresis and constitutive nonlinearities inherent to ferromagnetic materials. In the first step of the development, we construct Helmholtz and Gibbs energy relations at the mesoscopic or lattice level based on the assumption that magnetic moments or spins are restricted to two orientations. Direct minimization of the Gibbs energy yields local average magnetization relations appropriate for operating regimes in which relaxation mechanisms are negligible whereas the balance of the Gibbs and relative thermal energies through Boltzmann principles provides local models which incorporate mechanisms such as thermal after-effects. To construct macroscopic relations that incorporate material nonhomogeneities, polycrystallinity, and variable effective fields, we employ stochastic homogenization techniques based on the assumption that parameters such as local coercive and interaction fields are manifestations of underlying distributions. The resulting framework quantifies in a natural manner the anhysteretic magnetization provided by decaying ac fields and guarantees the closure of biased minor loops once transient accommodation and after-effects are complete. Furthermore, noncongruency at differing magnetization levels is achieved with certain choices for the energy functionals. Hence, the framework provides an energy basis for certain extended Preisach models and the relation of the framework to several macroscopic hysteresis models is detailed. The behavior of both the nonlinear anhysteretic relations and full hysteresis model are validated through comparison with steel and nickel data.
Shipboard Experiments for a Multihop 802.11 Communications System-Rf Channel Characterization and Mac Performance Measurement (2006)

Wireless relays offer one approach to providing communications among small teams operating below-decks on neutral or hostile ships. Two sets of experiments were conducted aboard a container ship to determine the viability of this approach. In the first set of experiments, RF propagation loss and coherence bandwidth were assessed in both the 2.4 GHz and 5.8 GHz ISM bands. In the second set, packet latency and throughput were assessed for 802.11a and 802.11b networks operating in multihop configurations with hidden nodes. On the basis of these experiments, it is concluded that the wireless relay concept is workable in the shipboard environment using 802.11 wireless networks. The 802.11 variants offer different trades among data rate, relay separation, and supporting hardware requirements.
Expression of smooth muscle caldesmon in developing chicken gizzard (1998)

Caldesmon is an actin/calmodulin/tropomyosin protein located in the thin filaments of smooth muscle cells and microfilaments of nonmuscle cells. Two isoforms of caldesmon, h- and l-types, shown to exist in vertebrate smooth and nonmuscle cells respectively, are produced by alternative splicing of the caldesmon mRNA encoded by a single gene. To study the expression of smooth muscle specific h-caldesmon during the differentiation of mesenchymal cells into smooth muscle cells, soluble protein and total RNA from the gizzard primordium in the gut region of 5-day and gizzards of 7-, 9-, 13-, 17- and 21-day embryos and 2-days post-hatch chicks were extracted and analyzed for caldesmon expression at both protein and mRNA levels. Western blot analysis of proteins and immunofluorescence microscopy of tissue section were carried out using an antibody specific for h-caldesmon. Total RNA was analyzed by Northern blotting using a caldesmon cDNA probe, and h- and l-caldesmon cDNAs were identified due to the difference in their molecular sizes (4.8 and 4.1 kb respectively). The mRNA was also analyzed by reverse transcribed-polymerase chain reaction (RT-PCR) and Southern blot analysis. Our results show that the I-caldesmon mRNA was expressed at higher levels in the gizzard primordium during the early stages of development, and decreased gradually during growth. The h-caldesmon protein and mRNA, not expressed at day 5, is minimally expressed at day 7 and is fully turned on by day 9. Additionally, sequence analyses of the RT-PCR products of I-caldesmon showed that it lacked the spacer region, as predicted. RT-PCR analysis of total RNA gave two h-caldesmon fragments. These two fragments were identified as two different isoforms of h-caldesmon since they both contained the spacer region. They also showed homology in the region of exon 4 had differences in the region of exon 3b.
A discussion on a quantum key remote distribution scheme not based on the quantum entanglement state (2004)

Most schemes of quantum key remote distribution available mainly deal with the quantum repeater based on quantum entanglement swapping. However, as the quantum repeater has many insurmountable shortcomings, this paper, relying on the existing fairly mature technique, proposes a highly efficient QKD scheme with authentication mechanism from a new perspective of scheme not based on entanglement swapping, overcoming the low efficiency of the entanglement swapping scheme. By means of the quantum authentication mechanism, this scheme is capable of preventing and detecting any active attacks from any point in the quantum network. The scheme proposed has realized authentication and key distribution in the quantum channel at the same time, providing the authentication mechanism of this type of remote key distribution network with a reference. This paper first briefly analyzes the shortcomings of the quantum repeater scheme based on entanglement swapping and introduces the idea of highly efficient quantum key negotiation by means of the pseudo random sequence. Then a key distribution with authentication protocol based on shared secret is presented followed by a description of the application of this scheme in the quantum key distribution network.
High resolution mass spectrometry imaging using 3 micron laser ablation (2023)

We report a single-cell level resolution (≤10 µm), laser desorption-based mass spectrometry imaging platform. An optical parametric amplifier is used to generate ∼100 ps, 200 nJ pulses at around 3 µm with a maximum repetition rate of 500 kHz. The pulses are tightly focussed on to fresh frozen animal tissue samples with a thickness of 10 µm. Small volumes of tissue are readily ablated by the laser and are subsequently chemically analyzed using a Rapid Evaporative Ionization Mass Spectrometry (REIMS) source installed on a time of flight mass analyzer. Raster scanning the samples through the laser focus enables the acquisition of mass spectrometry data which can be processed into images with pixel size 10 µm without oversampling, corresponding to cellular level resolution.
A polymorphism in the enhancer region of the thymidylate synthase promoter influences the survival of colorectal cancer patients treated with 5-fluorouracil (2001)

High levels of thymidylate synthase (TS) expression have been associated with poor survival of colorectal cancer (CRC) patients to 5-fluorouracil (5-FU)-based chemotherapy. Recent evidence suggests that a polymorphism within the enhancer region of the TS gene promoter can influence TS expression, with the triple repeat homozygote (3R/3R) being associated with significantly higher tumour TS levels than either the double repeat homozygote (2R/2R) or heterozygotes (2R/3R). In the present study we investigated whether TS genotype was associated with the degree of survival benefit from chemotherapy in 221 Dukes' C stage CRC patients. Patients with the 3R/3R polymorphism (n = 58, 26%) showed no significant long-term survival benefit from chemotherapy (RR = 0.62, 95% CI: 0.30-1.25, P = 0.18), whereas those with the 2R/2R or 2R/3R genotype (n = 163, 74%) showed significant gains in survival from this treatment (RR = 0.52, 95% CI: 0.52-0.82, P = 0.005). These results demonstrate that a polymorphism within the TS gene, probably through its effect on TS expression levels, can influence the survival benefit obtained by CRC patients from 5-FU-based chemotherapy.
Silicon photonic wavelength cross-connect with integrated MEMS switching (2019)

We report on monolithically integrated wavelength cross-connects (WXCs) on an enhanced silicon photonic platform with integrated micro-electro-mechanical-system (MEMS) actuators. An 8 × 8 WXC with 8 wavelength channels comprising 16 echelle gratings and 512 silicon photonic MEMS switches is integrated on a 9.7 mm × 6.7 mm silicon chip. The WXC inherits the fundamental advantages of silicon photonic MEMS space switches, including low loss, broad optical bandwidth, large fabrication tolerance, and simple digital control. The WXC exhibits a low crosstalk of −30 dB, a submicrosecond switching time of 0.7 µs, and on-chip optical insertion losses varying from 8.8 dB to 16.4 dB. To our knowledge, it is the largest channel capacity (64 channels = 8 ports × 8 wavelengths) integrated WXC ever reported.
Media Presentation Synchronisation for Non-monolithic Rendering Architectures (2007)

Non-monolithic renderers are physically distributed me- dia playback engines. Non-monolithic renderers may use a number of different underlying network connection types to transmit media items belonging to a presentation. There is therefore a need for a media based and inter-network- type synchronization algorithm. NeighbourCast is a algo- rithm for synchronising nodes in a wireless ad hoc network. In this paper, we introduce an efficient extension to Neigh- bourCast, that allows non-monolithic rendering nodes to be synchronised across multiple networks, during a media presentation. Our results show that our algorithm matches the requirements we enlist for non-monolithic renderer syn- chronisation. Our results meet the requirements imposed by lip synchronization research done earlier.
Estudo de antioxidantes no controle do processo oxidativo do biodiesel (2013)

Para os produtores e revendedores do Biodiesel o impasse que confere ao controle de qualidade de seus produtos e relativo a uma elevada tendencia a oxidacao, caracteristica da origem lipidica do combustivel. O resultado sobre o produto e a facil degradacao com tempo de vida util reduzido, alem dos produtos gerados na oxidacao causam corrosao durante o periodo de armazenamento. Levando em consideracao a importância da adicao de antioxidantes para garantir a qualidade do biocombustivel, apresentando-se eficaz no retardamento ou na inibicao da oxidacao no biodiesel, se faz necessario o desenvolvimento de novos estudos em substâncias, sobretudo as de origem natural, que manifestem atividade antioxidante. Este estudo tem como objetivo julgar e testar as propriedades do Neem, Azadirachta indica , que apresenta um potente antioxidante, revelando se eficiente para o controle do processo oxidativo do biodiesel, ja que, estudos de antioxidantes naturais no biodiesel sao mais escassos. O estudo ainda centra-se no armazenamento do produto em posto de gasolina. A metodologia utilizada para a realizacao do estudo foi o extrator de Soxhlet , um sistema comumente usado para a extracao.
Palladium‐Catalyzed Stille Cross‐Coupling Reaction of Aryl Chlorides using a Pre‐Milled Palladium Acetate and XPhos Catalyst System (2008)

Abstract A highly active catalyst system based upon a biaryl monophosphine ligand, XPhos, for the palladium‐catalyzed Stille reaction has been developed. This method allows for the coupling of aryl chlorides with a range of tributylarylstannanes to produce the corresponding biaryl compounds in good to excellent yields (61–98%) in short reaction times (4 h). Palladium(II) acetate [Pd(OAc) 2 ] and XPhos in a 1:1.1 ratio were milled into a fine powder that was used as pre‐catalyst for these reactions.
Epistemic Logic and Epistemology, the state of their affairs (2005)

At first sight, the modern agenda of epistemology has little to do with logic. Topics include different definitions of knowl-edge, its basic formal properties, debates between externalist and internalist positions, and above all: perennial encounters with sceptics lurking behind every street corner, especially in the US. The entry ‘Epistemology ’ in the Routledge Encyclope-dia of Philosophy (Klein, 1993) and the anthology (Kim and Sosa, 2000) give an up-to-date impression of the field. Now, epistemic logic started as a contribution to epistemology, or at least a tool in its modus operandi, with the seminal book Knowledge and Belief (Hintikka’s, 1962, 2005). Formulas like Ki / for ‘‘the agent i knows that /’’ Bi / for ‘‘the agent i believes that’’ provided logical forms for stating and analyzing philosophical propositions and arguments. And more than that, their mod-el-theoretic semantics in terms of ranges of alternatives pro-vided an appealing extensional way of thinking about what agents know or believe in a given situation. In particular, on Hintikka’s view, an agent knows those propositions which are true in all situations compatible with what she knows about the actual world; i.e., her current range of uncertainty:
Identification of a distinct family of genes encoding atypical odorant‐binding proteins in the malaria vector mosquito, Anopheles gambiae (2003)

We performed a genome-wide analysis for candidate odorant-binding protein (OBP) genes in the malaria vector Anopheles gambiae (Ag). We identified fifty-seven putative genes including sixteen genes predicted to encode distinct, higher molecular weight proteins that lack orthologues in Drosophila. Expression analysis indicates that several of these atypical AgOBPs are transcribed in chemosensory organs in adult and immature stages. Phylogenetic analysis of the Anopheles and Drosophila OBP families reveals these proteins fall into several clusters based on sequence similarity and suggests the atypical AgOBP genes arose in the mosquito lineage after the divergence of mosquitoes and flies. The identification of these AgOBP genes is the first step towards determining their biological roles in this economically and medically important insect.
Relative geologic time estimation using a deep convolutional neural network (2019)

We propose applying a deep learning technique to directly and automatically generate Relative Geologic Time (RGT) volumes from seismic images. In this method, a multi-layer convolutional neural network (CNN) is constructed and trained with synthetic input seismic images and target RGT images. Although the network is trained using only synthetic images, it generates accurate results on real seismic images. The method automatically captures complex geologic structures in the input, including multiple crossing faults and significantly folded horizons, without any need for manual picking. Presentation Date: Tuesday, September 17, 2019 Session Start Time: 8:30 AM Presentation Time: 8:30 AM Location: 221C Presentation Type: Oral
Doppler ultrasound techniques for landmine detection (2004)

The paper presents measurements taken with a scanning ultrasonic Doppler vibrometer on a landmine buried separately in sand and in grass-covered soil. The signal obtained with a laser Doppler vibrometer experiences a large variability that is due to loss of spatial coherence upon scattering from moving grass blades. Ultrasonic sensing is not affected by this limitation since the acoustic speckle is much larger than its optical counterpart. Moreover, the slightest hint of air motion enhances the motion of the grass blades, which adds to the optical decoherence and subsequent loss of useful signal. It is shown also that the ultrasonic system has no problem penetrating the layer of grass and detecting the location of the buried target excited by a mechanical shaker.
Identification and verification of heat shock protein 60 as a potential serum marker for colorectal cancer (2011)

Colorectal cancer (CRC) is a major public health issue worldwide, and novel tumor markers may contribute to its efficient management by helping in early detection, prognosis or surveillance of disease. The aim of our study was to identify new serum biomarkers for CRC, and we followed a phased biomarker discovery and validation process to obtain an accurate preliminary assessment of potential clinical utility. We compared colonic tumors and matched normal tissue from 15 CRC patients, using two-dimensional difference gel electrophoresis (2D-DIGE), and identified 17 proteins that had significant differential expression. These results were further confirmed by western blotting for heat shock protein (HSP) 60, glutathione-S-transferase Pi, α-enolase, T-complex protein 1 subunit β, and leukocyte elastase inhibitor, and by immunohistochemistry for HSP60. Using mAbs raised against HSP60, we developed a reliable (precision of 5-15%) and sensitive (0.3 ng·mL(-1)) immunoassay for the detection of HSP60 in serum. Elevated levels of HSP60 were found in serum from CRC patients in two independent cohorts; the receiver-operating characteristic curve obtained in 112 patients with CRC and 90 healthy controls had an area under the curve (AUC) of 0.70, which was identical to the AUC of carcinoembryonic antigen. Combination of serum markers improved clinical performance: the AUC of a three-marker logistic regression model combining HSP60, carcinoembryonic antigen and carbohydrate antigen 19-9 reached 0.77. Serum HSP60 appeared to be more specific for late-stage CRC; therefore, future studies should evaluate its utility for determining prognosis or monitoring therapy rather than early detection.
Table S2 from Inhibition of BET Bromodomain Proteins with GS-5829 and GS-626510 in Uterine Serous Carcinoma, a Biologically Aggressive Variant of Endometrial Cancer (2023)

&lt;p&gt;Groups and dosing description of the in vivo drug study on USC-ARK2 xenograft.&lt;/p&gt;
New Reactions of Phenyl Isocyanate and Ethyl Alcohol1 (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew Reactions of Phenyl Isocyanate and Ethyl Alcohol1I. C. KogonCite this: J. Am. Chem. Soc. 1956, 78, 19, 4911–4914Publication Date (Print):October 1, 1956Publication History Published online1 May 2002Published inissue 1 October 1956https://pubs.acs.org/doi/10.1021/ja01600a027https://doi.org/10.1021/ja01600a027research-articleACS PublicationsRequest reuse permissionsArticle Views806Altmetric-Citations81LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Porcine Heterotopic Heart Transplantation Protocol for Delivery of Therapeutics to a Cardiac Allograft (2022)

Cardiac transplantation is the gold standard treatment for end-stage heart failure. However, it remains limited by the number of available donor hearts and complications such as primary graft dysfunction and graft rejection. The recent clinical use of an ex vivo perfusion device in cardiac transplantation introduces a unique opportunity for treating cardiac allografts with therapeutic interventions to improve function and avoid deleterious recipient responses. Establishing a translational, large-animal model for therapeutic delivery to the entire allograft is essential for testing novel therapeutic approaches in cardiac transplantation. The porcine, heterotopic heart transplantation model in the intraabdominal position serves as an excellent model for assessing the effects of novel interventions and the immunopathology of graft rejection. This model additionally offers long-term survival for the pig, given that the graft is not required to maintain the recipient's circulation. The aim of this protocol is to provide a reproducible and robust approach for achieving ex vivo delivery of a therapeutic to the entire cardiac allograft prior to transplantation and provide technical details to perform a survival heterotopic transplant of the ex vivo perfused heart.