gebhart/patrepeval huggingface dataset:
Recruitment of a novel zinc‐bound transcriptional factor by a bacterial HMGA‐type protein is required for regulating multiple processes in Myxococcus xanthus (2006)

Enhanceosome assembly in eukaryotes often requires high mobility group A (HMGA) proteins. In prokaryotes, the only known transcriptional regulator with HMGA-like physical, structural and DNA-binding properties is Myxococcus xanthus CarD. Here, we report that every CarD-regulated process analysed also requires the product of gene carG, located immediately downstream of and transcriptionally coupled to carD. CarG has the zinc-binding H/C-rich metallopeptidase motif found in archaemetzincins, but with Q replacing a catalytically essential E. CarG, a monomer, binds two zinc atoms, shows no apparent metallopeptidase activity, and its stability in vivo absolutely requires the cysteines. This indicates a strictly structural role for zinc-binding. In vivo CarG localizes to the nucleoid but only if CarD is also present. In vitro CarG shows no DNA-binding but physically interacts with CarD via its N-terminal and not HMGA domain. CarD and CarG thus work as a single, physically linked, transcriptional regulatory unit, and if one exists in a bacterium so does the other. Like zinc-associated eukaryotic transcriptional adaptors in enhanceosome assembly, CarG regulates by interacting not with DNA but with another transcriptional factor.
Principles of Turbomachinery (1956)

Principles of turbomachinery , Principles of turbomachinery , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
Integrated Seismic Stratigraphy and Seismic Geomorphology; Workflows and Techniques (2010)

It has long been recognized that significant geologic information can be derived from seismic data. Initially, these observations were limited to interpretations of 2D seismic data, however, within the last 25 years such observations have been extended to 3D seismic volumes. The workflow that yields the greatest geologic insights involves the integration of seismic stratigraphy and seismic geomorphology. The comprehensive iteration of these two disciplines yields insights as to what depositional elements are present and consequently lead to a prediction of lithology distribution. Stratigraphic insights are based on vertical seismic section views through the interpretation of stratigraphic architecture based on identification of reflection terminations, variations in seismic reflection amplitude and continuity, seismic reflection geometries such as mounding, clinoform patterns, and other patterns indicative of depositional settings. This two-dimensional approach, commonly referred to as seismic stratigraphy, was developed and first applied by Vail et al. (1977) and Mitchum et al. (1977). Although very useful, the ability to identify stratigraphic features in the vertical view is limited by seismic resolution, which is approximately equivalent to ¼ the seismic wavelength. Interpretation in plan view, made possible by the advent of 3D seismic data, is commonly referred to as seismic geomorphology. This approach, introduced by Posamentier (2000, 2004), identification of discrete depositional elements such as channels, reefs, sediment waves, and other geomorphic features can indicate depositional setting and in turn afford predictions regarding lithology distribution. The ability to identify stratigraphic features in plan view is limited by seismic detectability, yielding images as much as an order of magnitude finer scale than images in vertical view which, as previously stated are limited by seismic resolution.
Anomalous Surplus Energy Transfer Observed with Multiple FRET Acceptors (2009)

We conclude that either an additional energy transfer pathway exists when multiple acceptors are present, or that a theoretical assumption on which the kinetic model prediction is based is incorrect.
Insulin‐feedback via PI3K‐C2α activated PKBα/Akt1 is required for glucose‐stimulated insulin secretion (2010)

Phosphatidylinositide 3-kinases (PI3Ks) play central roles in insulin signal transduction. While the contribution of class Ia PI3K members has been extensively studied, the role of class II members remains poorly understood. The diverse actions of class II PI3K-C2alpha have been attributed to its lipid product PI(3)P. By applying pharmacological inhibitors, transient overexpression and small-interfering RNA-based knockdown of PI3K and PKB/Akt isoforms, together with PI-lipid profiling and live-cell confocal and total internal reflection fluorescence microscopy, we now demonstrate that in response to insulin, PI3K-C2alpha generates PI(3,4)P(2), which allows the selective activation of PKBalpha/Akt1. Knockdown of PI3K-C2alpha expression and subsequent reduction of PKBalpha/Akt1 activity in the pancreatic beta-cell impaired glucose-stimulated insulin release, at least in part, due to reduced glucokinase expression and increased AS160 activity. Hence, our results identify signal transduction via PI3K-C2alpha as a novel pathway whereby insulin activates PKB/Akt and thus discloses PI3K-C2alpha as a potential drugable target in type 2 diabetes. The high degree of codistribution of PI3K-C2alpha and PKBalpha/Akt1 with insulin receptor B type, but not A type, in the same plasma membrane microdomains lends further support to the concept that selectivity in insulin signaling is achieved by the spatial segregation of signaling events.
Boron‐11 imaging with a three‐dimensional reconstruction method (1992)

A three-dimensional projection reconstruction technique is described for imaging boron-11 distributions, with potential application to boron neutron capture therapy. The method samples a spherical volume of k space uniformly to obtain a 32 x 32 x 32 matrix with voxel size of 0.42 cm3. A signal-to-noise ratio (S/N) of 3 was obtained in 8.5 minutes in a phantom containing 75 micrograms/mL of boron in borocaptate sodium (BSH). Images were obtained in a dog after cessation of an intravenous infusion of BSH and again 30 minutes later, with a maximum boron S/N of about 12. Boron levels in the brain dropped about 6%-8% and were more diffusely distributed on the images obtained 30 minutes after BSH infusion.
An electron spin resonance study of alkyl radical addition to diethyl vinylphosphonate (1981)

The irreversible addition of alkyl radicals to diethyl vinylphosphonate to give the α-phosphorylalkyl radicals (1) has been studied by e.s.r. spectroscopy at 233 K in hydrocarbon solvents. The rate constants for addition (kadd) have R·+ H2CCHP(O)(OEt)2 [graphic omitted] RCH2ĊHP(O)(OEt)2(1) been determined relative to those (2kAt) for self-reaction of (1) for a series of addenda. The values of 2kAt have been measured in separate kinetic e.s.r. experiments for (1; R = Me)(2.0 × 109 dm3 mol–1 s–1) and (1; R = But)(5.0 × 108 dm3 mol–1 s–1) and thus absolute values of kadd were obtained. The rate constant kadd increases along the series R·= Me·(2.5 × 103 dm3 mol–1 s–1) < Rprim· < Rsec· < But·(5.9 × 104 dm3 mol–1 s–1) and this order is interpreted in terms of the over-riding importance of polar effects in determining the size of the barrier for addition of these nucleophilic radicals to the electron deficient alkene.
Performance Gains from Speech-enhanced Simulation in Military Flying Training (2010)

Flight simulation is a proven technique for training technical and procedural skills, but team skills present needs that remain unmet by simulator technology. Communication and coordination, two skills representative of this gap, are typically incorporated into simulation via human role players, a practice that entails cost, introduces variation, and can compromise availability of training. In this article we explore the use of speech-interactive synthetic teammates to bring team skills into simulation-based training. We report on a US Air Force study that led to the development of a desktop air traffic pattern simulation for practicing radio communications, and present findings from a study conducted with US Air Force student pilots who employed this system during part of their pilot training. The work reported here addresses two questions. First, can contemporary desktop simulation augmented with intelligent agents and voice recognition provide training gains in communications performance among student pilots? Second, will users accept this approach?
Nitroethylation of Vinyl Triflates and Bromides (2013)

A two-carbon homologation of vinyl triflates and bromides for the synthesis of homoallylic nitro products is described. This palladium-catalyzed double coupling of nitromethane exploits the anion stabilizing and leaving group properties of nitromethane, generating the homo allyl nitro products via a tandem cross-coupling/π-allylation sequence. The resultant process provides a mild and convenient entry to nitroethylated products, which are versatile precursors to β,γ-unsaturated carbonyls, homoallylic amines, and nitrile oxides.
Immigrant Students in the U.S. Chemistry Classroom: An Educational Opportunity and Challenge (2015)

Close to one-quarter of the U.S. population is an immigrant or the child of an immigrant. This editorial outlines how chemistry educators have the opportunity to address this new group in four important ways: (i) by considering pedagogical, systematic, and content responses to working with immigrant students; (ii) educating for international connections; (iii) including new countries and cultures in educational content; and (iv) working with undocumented students.
Problems and Thinking on Construction of National Model Higher Vocational Colleges (2011)

There existed two problems in the construction of national model higher vocational colleges,which were the unclearly defined objectives and the undefined emphasis of constructing,inspecting and accepting.The construction of model higher vocational colleges should focus on being model,and the demonstrative character should have adequate historical accumulation.Finally,the grassroots' intelligence should be given full play to the development of higher vocational education.
CcpA - a regulatory protein involved in cellobiose inducible lactose metabolism in Lactococcus lactis (2000)

Conference Abstract| October 01 2000 CcpA - a regulatory protein involved in cellobiose inducible lactose metabolism in Lactococcus lactis T. Aleksandrzak; T. Aleksandrzak 1IBB PAS, Pawinskiego 5a, 02–106 Warsaw, Poland Search for other works by this author on: This Site PubMed Google Scholar J. Kok; J. Kok *University of Groningen, Kerklaan 30, 9752 NN Haren, The Netherlands Search for other works by this author on: This Site PubMed Google Scholar J. Bardowski J. Bardowski 1IBB PAS, Pawinskiego 5a, 02–106 Warsaw, Poland Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (2000) 28 (5): A192. https://doi.org/10.1042/bst028a192 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation T. Aleksandrzak, J. Kok, J. Bardowski; CcpA - a regulatory protein involved in cellobiose inducible lactose metabolism in Lactococcus lactis. Biochem Soc Trans 1 October 2000; 28 (5): A192. doi: https://doi.org/10.1042/bst028a192 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 2000 Biochemical Society2000 Article PDF first page preview Close Modal You do not currently have access to this content.
Structural studies on induced antibodies with defined idiotypic speci- ficities. I. The heavy chains of anti-p-azophenylarsonate antibodies from a/j mice bearing a cross-reactive idiotype. (1975)

Amino acid sequence analysis has been performed on three groups of heavy (H) chains of A/J mice. H chains derived from unimmunized animals were compared to anti-p-azophenylarsonate (anti-Ar) antibodies which were further subdivided into those possessing and those depleted of a cross-reacting idiotype (CRI). It was found that anti-Ar antibodies bearing the CRI are homogeneous through the first hypervariable region of the H chain. The same sequence was obtained for pooled antibody isolated from the ascites fluid of 18 A/J mice or from a single mouse. The H chains appear to belong to a minor V-H subgroup. In the first 30 positions Anti-Ar antibodies depleted of the CRI had the same sequence as those containing the CRI (with small amounts of heterogeneity at some positions), but contained a mixture of sequences in the first hypervariable region of the H chain. These studies indicate that antibodies with similar specificity and with identical framework sequences, but which differ in their hypervariable regions, contain different idiotypic determinants, and support the concept that the idiotypic determinants reside primarily within hypervariable regions.
Aqueous Extract of Black Maca (Lepidium meyenii) on Memory Impairment Induced by Ovariectomy in Mice (2008)

The present study aims to test two different doses of aqueous extract of black maca on learning and memory in ovariectomized (OVX) mice and their relation with malonalehyde (MDA), acetylcholinesterase (Ache) and monoamine oxidase (MAO) brain levels. Female mice were divided into five groups: (i) naive (control), (ii) sham, (iii) OVX mice and OVX mice treated with (iv) 0.50 g kg(-1) and (v) 2.00 g kg(-1) black maca. Mice were orally treated with distilled water or black maca during 35 days starting 7 days after surgery. Memory and learning were assessed using the water Morris maze (from day 23-27) and the step-down avoidance test (days 34 and 35). At the end of each treatment, mice were sacrificed by decapitation and brains were dissected out for MDA, Ache and MAO determinations. Black maca (0.5 and 2.0 g/kg) increased step-down latency when compared to OVX control mice. Black maca decreased MDA and Ache levels in OVX mice; whereas, no differences were observed in MAO levels. Finally, black maca improved experimental memory impairment induced by ovariectomy, due in part, by its antioxidant and Ache inhibitory activities.
Revised reference values for selenium intake (2015)

The German, Austrian and Swiss nutrition societies are the joint editors of the 'reference values for nutrient intake'. They have revised the reference values for the intake of selenium and published them in February 2015. The saturation of selenoprotein P (SePP) in plasma is used as a criterion for the derivation of reference values for selenium intake in adults. For persons from selenium-deficient regions (China) SePP saturation was achieved with a daily intake of 49μg of selenium. When using the reference body weights the D-A-CH reference values are based upon, the resulting estimated value for selenium intake is 70μg/day for men and 60μg/day for women. The estimated value for selenium intake for children and adolescents is extrapolated using the estimated value for adults in relation to body weight. For infants aged 0 to under 4 months the estimated value of 10μg/day was derived from the basis of selenium intake via breast milk. For infants aged 4 to under 12 months this estimated value was used and taking into account the differences regarding body weight an estimated value of 15μg/day was derived. For lactating women compared to non-lactating women a higher reference value of 75μg/day is indicated due to the release of selenium with breast milk. The additional selenium requirement for pregnant women is negligible, so that no increased reference value is indicated.
Hemodynamic and Electrocardiographic Effects of Almotriptan in Healthy Volunteers (2001)

We studied the possible cardiovascular effects of single oral doses of 12.5, 25, and 50 mg of almotriptan, a new triptan for treatment of migraine, in a randomized, double-blind, four-way crossover, placebo-controlled study in 24 healthy volunteers aged 18 to 35 years. Doses were given at 1-week intervals. Cardiovascular effects were assessed by frequent recording of blood pressure and heart rate, 12-lead electrocardiogram (ECG) (recorded at 25 mm/s paper speed and 1 cm/mV and at 50 mm/s and 2 cm/mV), and continuous ECG monitoring for 12 h after each dose. ECG variables, PR, QRS, QT interval, and QT dispersion, were measured. QT intervals were adjusted for heart rate using Bazett's formula. None of the doses of almotriptan differed significantly from placebo with respect to PR, QRS, or QTc intervals, QTc dispersion, heart rate, or continuous ECG monitoring. Almotriptan 12.5 mg did not differ significantly from placebo with respect to systolic or diastolic blood pressure, but almotriptan 25 and 50 mg raised systolic blood pressure by a mean of 2.78 and 4.17 mm Hg, and diastolic blood pressure by 3.77 and 6.11 mm Hg, respectively, during 0 to 4 h after dosing. Thus none of the doses of almotriptan affected the ECG, and the 12.5-mg dose (the expected therapeutic dose) had no hemodynamic effects. Almotriptan in doses of 25 and 50 mg caused a small, dose-related increase in systolic and diastolic blood pressure, as seen with other triptans.
Graphene-extracted membrane lipids facilitate the activation of integrin αvβ8 (2020)

Despite the remarkable electrochemical properties of graphene, strong van der Waals attraction between graphene and biomolecules often causes cytotoxicity, which hinders its applications in the biomedical field. Unfortunately, surface passivation of graphene might stimulate undesired immune response as the nanomaterial triggers cytokine production through membrane receptor activation. Herein, we use all-atom Molecular Dynamics (MD) simulations to unravel the underlying mechanism of graphene-induced inside-out activation of integrin α<sub>v</sub>β<sub>8</sub>, a prominent membrane receptor expressed in immune cells. We model the transmembrane (TM) domains of integrin α<sub>v</sub>β<sub>8</sub> in a 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) lipid bilayer and observe the structural changes in the integrin-membrane complex when interacting with a graphene nanosheet across the membrane. We find that the β<sub>8</sub> TM domain interacts with the graphene nanosheet directly or indirectly through extracted lipids, facilitating the pulling of a β<sub>8</sub> subunit away from an α<sub>v</sub> subunit and thus leading to the disruption of the TM domain association by breaking the hydrophobic cluster in the cytoplasmic domains of the α<sub>v</sub> and β<sub>8</sub> subunits. Alanine substitution of two conserved phenylalanine residues on the α<sub>v</sub> subunit at this hydrophobic cluster further reveals the importance of a stable T-shaped structure in retaining integrin in its inactive state. Our results agree with previous studies on the interactions between other integrin subtypes and their endogenous activators, suggesting an intriguing role that the graphene nanosheet may play in the integrin-related signal transduction during its interaction with the membrane.
Breast cancer and reproductive history from genealogical data. (1980)

With the use of data from the Utah State Cancer Registry and Utah genealogical data, an analysis of 236 breast cancer patients and 937 controls matched on year of birth showed that a late age at the birth of the first child was most strongly associated with incidence of breast cancer (relative odds = 2.0; P less than 0.001). A strong interaction was found between age at first delivery (AFD) and age at last delivery (ALD). The association of AFD with breast cancer incidence was strongest for women with an ALD before 35 years of age even after adjustment for partly (relative odds = 4.1; P less than 0.001). Decreased parity was not significantly associated with breast cancer.
Dermokine expression in intraductal papillary-mucinous neoplasm and invasive pancreatic carcinoma. (2012)

Serum DK is a potential biomarker in IPMN and invasive ductal carcinoma, when used in combination with conventional biomarkers.
Internal crack initiation in high cycle fatigue of Ti-6Al-4V alloys at cryogenic temperatures (1990)

As the maximum stress is decreased, the morphology of subsurface crack initiation site changes from consisting of a single facet to of many facets. The facet was identified as a cracked α phase by its morphology and composition analysis. The lower the maximum stress, the larger the size of subsurface crack initiation site. Using 'fs', the size of the projection of the subsurface crack initiation site on the main crack propagating plane as a shape parameter, the size of the subsurface crack initiation site can be related unequivocally to the maximum stress regardless of impurity concentration, microstructure and temperature. The dependence of initiation site size on the maximum stress can be accounted for by an assumption that the microcrack growth is controlled by a threshold condition.
Penerapan Metode Distribution Requirement Planning Sebagai Upaya untuk Meminimumkan Bullwhip Effect pada Distributor Minyak Goreng (Studi kasus PT. Surya Mandiri Distribusi) (2023)

Distributors are parties who play an important role in trade because distributors are intermediaries between producers and consumers. PT Surya Mandiri Distribusi is a company engaged in the distribution of cooking oil. In distribution activities, this company often experiences product stock discrepancies which results in a high bullwhip effect phenomenon. This study aims to minimize the bullwhip effect that occurs in cooking oil distributor companies. This study used the Distribution Requirement Planning (DRP) method to solve the problems in this study. Where this method aims to set the distribution schedule as well as plan the number of products and their delivery time. The results of this study found that the application of the DRP method can reduce the value of the bullwhip effect in PT Surya Mandiri Distribusi by 17%. The application of the DRP method to distribution activities at PT Surya Mandiri Distribusi not only facilitates the planning of goods for future needs but is also one way that can minimize the value of the Bullwhip Effect that occurs in the company.Distributor merupakan pihak yang memegang peranan penting dalam perdagangan karena distributor merupakan perantara antara produsen dan konsumen. PT Surya Mandiri Distribusi merupakan perusahaan yang bergerak dibidang distribusi minyak goreng. Dalam aktivitas pendistribusian, perusahaan ini sering mengalami ketidaksesuaian stok produk yang mengakibatkan terjadinya fenomena bullwhip effect yang tinggi. Penelitian ini bertujuan untuk meminimalkan bullwhip effect yang terjadi pada perusahaan distributor minyak goreng. Penelitian ini menggunakan metode Distribution Requirement Planning (DRP) untuk menyelesaikan permasalahan dalam penelitian ini. Dimana metode ini bertujuan untuk untuk mengatur jadwal distribusi serta merencanakan jumlah produk dan waktu pengirimannya. Hasil penelitian ini menemukan bahwa penerapan metode DRP dapat menurunkan nilai bullwhip effect yang ada pada PT Surya Mandiri Distribusi sebesar 17%. Penerapan metode DRP pada aktivitas distribusi di PT Surya Mandiri Distribusi tidak hanya mempermudah perencanaan barang untuk kebutuhan kedepan namun juga merupakan salah satu cara yang dapat meminimumkan nilai Bullwhip Effect yang terjadi pada perusahaan tersebut.