gebhart/patrepeval huggingface dataset:
Radioimmunoguided Surgery for Gastrointestinal Malignancies: An Analysis of 14 Years of Clinical Experience (1997)

BACKGROUND: The identification of all sites of intra-abdominal adenocarcinoma is key to optimal surgical resection and tumor staging. Conventional imaging methods and direct visualization and palpation have limited sensitivity and specificity. Radioimmunoguided surgery (RIGS) has a potential to improve these parameters. METHODS: The development of the RIGS concept is presented, and the studies of tumor localization, detection of disseminated disease, staging, and survival are correlated with the tumor biopsy of gastrointestinal carcinoma, particularly colorectal carcinoma. RESULTS: RIGS can detect clinically and histologically occult neoplasm. Also, by providing immediate intraoperative information, the RIGS approach improves surgical staging, impacts on surgical and medical care, and affects patient prognosis. CONCLUSIONS: RIGS may become the standard of care for the surgical staging and treatment of colorectal cancer and other gastrointestinal malignancies.
Visual-auditory spatial attention in human visual cortex (2010)

Purpose: To examine how auditory spatial attention influences responses in early visual areas. Methods: Subjects were presented four stimuli simultaneously: two drifting gratings, one to the left and one to the right of central fixation, and two auditory tones, one to the left and one to the right ear. Auditory stimuli presented to the left ear was perceived as being on the left side of space, and vice versa. All four stimuli were presented in two successive intervals, with the speed of the visual gratings and the frequency of the auditory tones independently increased or decreased between the first and second interval. On any given trial, subjects were cued to attend the auditory stimulus in either the left or right ear and had to judge whether the attended stimulus contained the higher frequency tone in the first or second interval. Auditory frequency increment thresholds were determined prior to scanning, so as to maintain constant task difficulty throughout the scan. Subjects alternated between performing the task on the auditory stimulus in the left versus the right ear every 20-sec (6 blocks per scan, 8 trials per block). We measured fMRI responses to an unattended visual stimulus when attention was directed to an auditory stimulus on the same or the opposite side of space. Results: In early visual areas we found a larger fMRI response to an unattended visual stimulus when auditory attention was directed to the same side of space, compared to when auditory attention was directed to the opposite side of space. These results are consistent with a cross-modal mechanism of spatial attention in which attention to a stimulus in one region of space leads to an enhancement of the response to any other stimulus in the same spatial region, regardless of modality. Thus, when visual and auditory stimuli share a common spatial region, even an unattended visual stimulus can gain a processing advantage, yielding a larger fMRI response.
Extruded YBCO HTS Single Domain Bulk Materials for Permanent Magnets (2012)

Drilled YBCO bulk materials have been reported to possess good superconducting properties owing to their large specific areas which promote thermal exchange and oxygen diffusion. Extrusion process can be used as an outstanding way to develop artificially thin-wall YBCO ceramics. YBa2Cu3O7-δ single domains were successfully grown by using Top-Seeded Infiltration Growth from extruded Y2BaCuO5 preforms with artificial holes. They show a free-crack microstructure with a uniform distribution of Y2BaCuO5 inclusions. The flux mapping confirmed the single-domain criterion, and the critical current density was found larger than the one of the drilled material. The extruded ceramics were impregnated by resign/Fe-metal for reliability reinforcement.
Resolution of Hyperparathyroidism, Renal Osteodystrophy and Metastatic Calcification after Renal Homotransplantation (1968)

In 17 patients followed for an average of 18 months after renal homotransplantation, mean phosphate clearance was 18 ml per minute, tubular reabsorption of phosphate 60 per cent, and creatinine clearance 58 ml per minute. Calcium infusion tests performed in six were abnormal in all but one. Bone disease present in five patients improved or resolved in the post-transplant period. Hypercalcemia developed one and a half to six months after transplantation in nine patients, probably because of hyperparathyroidism present since operation but unmasked when phosphorus depletion was induced by aluminum hydroxide, with consequent increased hypercalcemia, hypercalciuria and negative calcium balance. In seven patients the hypercalcemia was mild and resolved when the antacid was changed to aluminum phosphate. One patient was given long-term phosphorus supplementation, and one required parathyroidectomy for control of hypercalcemia.
TGF-beta1 produced by gastric cancer cells affects mesothelial cell morphology in peritoneal dissemination. (1998)

In vitro morphologic change of mesothelial cells was observed following the addition of serum-free conditioned medium (SF-CM) from peritoneal dissemination cell line OCUM-2MD3. The same morphologic change of mesothelial cells was observed following the addition of 10 ng/ml TGF-beta1, but not following the addition of b-FGF, IGF-I, VEGF or PDGF-AA. In the in vivo study, mesothelial cells of mice treated with SF-CM from OCUM-2MD3 and TGF- beta1 were separated from one another, resulting in exposure of the submesothelial connective tissue. The molecular size of the mesothelial morphology changing activity was estimated by running the SF-CM from OCUM-2MD3 through a gel filtration column TSK-gel G2000SW. The mesothelial morphology changing activity was recognized at positions equivalent of Mr 6, 500-30,000. 25 kDa TGF-beta1 was detected in the active fraction from the TSK-gel G2000SW column and the SF-CM of OCUM-2MD3 by Western blotting using a monoclonal antibody against TGF-beta1. These findings suggest that TGF-beta1 produced by gastric cancer cells changes the morphology of mesothelial cells and may thus be closely associated with peritoneal dissemination.
Análisis del Diseño y Programación de Celdas en Entornos de Fabricación Ágil (2004)

espanolEl objetivo de este trabajo fue determinar un enfoque apropiado del diseno y de la programacion de una celda de fabricacion agil para que responda con rapidez, flexibilidad y competencia a cambios impredecibles del mercado. Se identifican como elementos fundamentales de la fabricacion agil las tecnologias de la fabricacion flexible y de la fabricacion esbelta. En este contexto se revisan las tecnicas de la tecnologia de grupos, identificando como idoneas las relativas al coeficiente de similitud. Tambien, se analiza el metodo kanban, estableciendo las caracteristicas a considerar para su adecuacion. Se concluye que la integracion de la tecnologia de grupos y del kanban facilita la fabricacion agil siempre que en el diseno se consideren los tiempos de preparacion, multiples hojas de proceso y multiples tipos de maquina. EnglishThe objective of this work was to determine an appropriate approach of design and scheduling in an agile manufacturing cell so it is able to respond quickly, flexibility and competitiveness to unpredictable changes of market. Technologies of flexible and lean manufacturing have been identified as fundamental elements of agile manufacturing. In this context, techniques of group technology have been reviewed, finding as suitable techniques those related to the similarity coefficient. In addition, kanban method has been analyzed setting its implementation characteristics. It is concluded that the integration of groups technology and kanban facilitates agile manufacturing if the cell design considers preparation times, multiple process plans and multiple machine types.
Sequence of Precursor Polyprotein Gene (Segment A) of Infectious Bursal Disease Viruses Isolated in Korea (2000)

The coding regions of segment A of two recent Korean very virulent (vv) infectious bursal disease virus (IBDV) isolates (KK1 and KSH) and one atypical IBDV isolate (K310) were amplified by reverse transcriptase-polymerase chain reaction, sequenced, and compared with published sequences for IBDV. The overall amino acid sequence similarity of the KK1 and KSH strains compared with foreign vvIBDV strains was between 97.43% and 98.02%. The KK1 and KSH strains, like vvIBDV strains, share unique amino acid residues at positions 222(A), 256(I), 294(I), and 299(S). The sequence of K310 strain was markedly different from other IBDV strains. The K310 strain had 12, 2, and 1 unique amino acid substitutions in the VP2 hypervariable region, VP4, and VP3 gene, respectively, and 3 of 12 substitutions in a VP2 hypervariable region were found in two hydrophilic regions known to be involved in antigenic determination. Also, the K310 strain had 222(S) and 254(S), which were found in variant IBDV strains. The SWSASGS heptapeptide is conserved in all Korean IBDV isolates. By phylogenetic analysis, KK1 and KSH were categorized in one group with foreign vvIBDV isolates, but K310 isolate was categorized in a separate group that was differentiated from the other IBDV strains compared. The K310 strain seemed to be evolved from a separate lineage of IBDV strain.
Hybrid Topological and 3D Dense Mapping through Autonomous Exploration for Large Indoor Environments (2020)

Robots require a detailed understanding of the 3D structure of the environment for autonomous navigation and path planning. A popular approach is to represent the environment using metric, dense 3D maps such as 3D occupancy grids. However, in large environments the computational power required for most state-of-the-art 3D dense mapping systems is compromising precision and real-time capability. In this work, we propose a novel mapping method that is able to build and maintain 3D dense representations for large indoor environments using standard CPUs. Topological global representations and 3D dense submaps are maintained as hybrid global map. Submaps are generated for every new visited place. A place (room) is identified as an isolated part of the environment connected to other parts through transit areas (doors). This semantic partitioning of the environment allows for a more efficient mapping and path-planning. We also propose a method for autonomous exploration that directly builds the hybrid representation in real time.We validate the real-time performance of our hybrid system on simulated and real environments regarding mapping and path-planning. The improvement in execution time and memory requirements upholds the contribution of the proposed work.
Excited-State Dynamics of Diindenoperylene in Liquid Solution and in Solid Films (2015)

The excited-state dynamics of diindenoperylene (DIP) are investigated in dilute solution and in a solid film at room temperature using picosecond photoluminescence and femtosecond transient absorption measurements. In solution, DIP undergoes a rapid (0.89 ns) internal conversion back to its ground state, with no detectable formation of triplet or other long-lived states. In the solid state, multiple emissive species are formed. The time-resolved photoluminescence signal is dominated by an intrinsic exciton that decays on a time scale of 166 ps. Emission from lower energy excimer-like species then persists for >10 ns. Transient absorption experiments indicate that the majority of the excited-state population relaxes to the ground state on the 166 ps time scale, but a smaller fraction (<10%) survives in longer-lived trap or defect states. The rapid internal conversion leads to transient heating that results in a derivative line shape in the transient absorption signal at longer delays. DIP does not appear to support long-lived singlet exciton states or singlet fission. The implications of these results for the function of DIP in organic solar cells are discussed.
Characterization of Primary Progressive Aphasia and Prediction of Naming Decline by Multi-Modality MRI (N1.002) (2017)

To characterize, cross-sectionally and longitudinally, patients with Primary Progressive Aphasia (PPA), by multi-modality brain MRI, and to look for potential prognostic markers of later decline in naming.
Solar pond-assisted heat pump heating system for commercial greenhouses (1980)

The clinical trial of a new drug "mamoclam" was carried out in patients with benign breast disease. The drug contains omega-3 polyunsaturated fatty acids, iodine and chlorophyll derivatives and is produced from the brown sea alga laminaria. The study involved 33 patients (mean age 42.5 +/- 1.1 yrs). Two tablets were administered thrice a day for three months. Examination included clinical evaluation of symptoms of mastopathy and dysalgomenorrhea, breast sonography and mammography. Therapeutic response presented as reduced mastalgia, premenopausal syndrome, dysmenorrhea and algomenorrhea, breast cyst regression as well as attenuated pain associated with benign breast disease and palpation. Positive response was reported in 94%. The drug should be recommended for benign breast disease treatment.
Inhibition of yeast inositol phosphorylceramide synthase by aureobasidin A measured by a fluorometric assay (1999)

Inositol phosphorylceramide synthase (IPC synthase) is an essential and unique enzyme in fungal sphingolipid biosynthesis and is the target of the cyclic nonadepsipeptide antibiotic aureobasidin A. As a first step towards understanding the mechanism of aureobasidin A inhibition, we developed a fluorometric HPLC assay for IPC synthase using the Saccharomyces cerevisiae enzyme and the fluorescent substrate analog 6-[N-(7-nitro-2,1, 3-benzoxadiazol-4-yl)amino]-hexanoyl ceramide (C(6)-NBD-cer). The kinetic parameters for C(6)-NBD-cer were comparable to those for the synthetic substrate N-acetylsphinganine used previously. Aureobasidin A acted as a tight-binding, non-competitive inhibitor with respect to C(6)-NBD-cer and had a K(i) of 0.55 nM.
Statistical medium optimization and DO-STAT fed-batch fermentation for enhanced production of tyrosine phenol lyase in recombinant Escherichia coli (2019)

Tyrosine phenol lyase (TPL) is a robust biocatalyst for the production of L-dihydroxyphenylalanine (L-DOPA). The improvement of TPL production is conducive to the industrial potential. In this study, the optimization of culture medium of recombinant Escherichia coli harboring TPL from Fusobacterium nucleatum (Fn-TPL) was carried out. Sucrose and combination of yeast extract and peptone were selected as carbon and nitrogen source, respectively. Their optimal concentrations were determined by Box-Behnken design and the synergistic effect between yeast extract and peptone was found to be significant, with p-value < 0.05. The DO-STAT fed-batch fermentation under optimized culture condition was established and the oxygen level was fixed at 20%. Both the biomass and Fn-TPL activity were significantly increased, which were 35.6 g dcw/L and 12292 U/L, respectively. The results obtained significantly promote the industrial production of L-DOPA production.
Errata and Addenda - Chemistry of Cyclopentadienones. (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleErrata and Addenda - Chemistry of Cyclopentadienones. Michael Ogliaruso, Michael Romanelli, and Ernest BeckerCite this: Chem. Rev. 1965, 65, 6, 717Publication Date (Print):December 1, 1965Publication History Published online20 October 2004Published inissue 1 December 1965https://doi.org/10.1021/cr60238a602RIGHTS & PERMISSIONSArticle Views53Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (119 KB) Get e-Alerts Get e-Alerts
QUANTIFICATION OF THE TIP MOVEMENT OF LITHOTRIPSY FLEXIBLE PNEUMATIC PROBES (2000)

The optical measurement system and in vitro fragmentation model developed allow one to quickly and reliably assess the performance of flexible pneumatic probes in vitro. This system can be used for general bench testing and basic research that can provide critical information for the design of more effective and efficient flexible pneumatic lithotripsy probes.
Diagnostic Yield of Colon Capsule Endoscopy for Crohn’s Disease Lesions in the Whole Gastrointestinal Tract (2020)

Abstract BACKGROUNDCrohn’s disease (CD) can involve the upper gastrointestinal (GI) tract as well as the small and large bowel. PillCam colon capsule endoscopy (PCCE-2) enables to observe the whole GI tract, but its diagnostic yield for CD lesions in the whole GI tract remains unknown. AIMTo elucidate the diagnostic yield of PCCE-2 in patients with CD.METHODSPatients with CD who underwent PCCE-2 and double-balloon endoscopy (DBE) using oral and anal approaches were evaluated for CD lesions in the whole GI tract. We divided the small bowel into three segments (jejunum, ileum, and terminal ileum), and the large bowel into four segments (right colon, transverse colon, left colon, rectum). Detection of ulcer scars, erosion, ulcers, bamboo joint-like appearance, and notch-like appearance was assessed in each segment. The diagnostic yield of PCCE-2 was analyzed based on the DBE results as the gold standard.RESULTSOf the total 124 segments, the sensitivities of PCCE-2 for ulcer scars, erosion, and ulcers were 83.3%, 93.8%, and 88.5%, respectively, and the specificities were 76.0%, 78.3%, and 81.6%, respectively. For the 60 small bowel segments, the sensitivities were 84.2%, 95.5%, and 90.0%, respectively, and the specificities were 63.4%, 86.8%, and 87.5%, respectively. For the 64 large bowel segments, the sensitivities were 80.0%, 90.0%, and 83.3%, respectively, and the specificities were 84.7%, 72.2%, and 77.6%, respectively.CONCLUSIONPCCE-2 provides a high diagnostic yield for lesions in the whole GI tract of patients with CD. Thus, we recommend its use as a pan-enteric tool in clinical settings.
A Review of Tunable Acoustic Metamaterials (2018)

Acoustic metamaterial science is an emerging field at the frontier of modern acoustics. It provides a prominent platform for acoustic wave control in subwavelength-sized metadevices or metasystems. However, most of the metamaterials can only work in a narrow frequency band once fabricated, which limits the practical application of acoustic metamaterials. This paper highlights some recent progress in tunable acoustic metamaterials based on various modulation techniques. Acoustic metamaterials have been designed to control the attenuation of acoustic waves, invisibility cloaking, and acoustic wavefront engineering, such as focusing via manipulating the acoustic impedance of metamaterials. The reviewed techniques are promising in extending the novel acoustics response into wider frequency bands, in that tunable acoustic metamaterials may be exploited for unusual applications compared to conventional acoustic devices.
Dual-Arm Mobile Manipulation Planning of a Long Deformable Object in Industrial Installation (2023)

In this letter, we present a planning method considering regrasp and mobility for the manipulation problem of a long deformable object in an industrial scenario. The object is carried through designated rollers by a dual-arm robot in the presence of environmental constraints. The problem is formulated by modeling the deformable object as a set of line segments and categorizing obstacles into different types. A hierarchical 2.5D manipulation planner is proposed, which first plans the ideal path of a deformable object in a 2D plane and obtains its topological representation. Next, dual-arm regrasps are determined by utilizing the deformation models, and collision-free paths are planned to meet topological constraints for the grippers. The feasibility of the proposed method is experimentally validated using a humanoid robot, by integrating the planner with a loco-manipulation planning framework and QP-based whole-body motion controller.
Consistency grammar for 3D indoor model checking (2020)

Abstract Indoor 3D models are digital representations of building interiors reconstructed from scanned data acquired by laser scanners, digital depth (RGBD) cameras, and CAD drawings. Consequently, there is noise in the source data and a notable variety in the methods used to treat the noise and to process these data into reconstructed models. Alas, the correctness of these reconstructions and thus their suitability for a given application are uncertain. There is a lack of a robust base logic that would allow for controlling the consistency of these (automatically) generated models. Fortunately, correctness criteria are well‐defined through existing international standards. Hence, we propose a conceptual framework based on formal grammars to check the semantic, geometric, and topological consistency of a reconstructed 3D model. The proposed method proceeds in three steps to validate the model: (1) correctness checking of individual components; (2) consistency verification of instances’ interactions; and (3) model consistency check for targeted applications. Our method identifies the components in the model that violate the given rules derived from the current standards and expert knowledge. Ultimately, we propose a quantified formulation of our method that may be straightforwardly integrated into industrial‐level model checkers. The approach is independent of level of details and reconstruction method.
The Neurosteroid, 3α‐Hydroxy‐5α‐pregnan‐20‐one, Protects against Bicuculline‐Induced Seizures during Ethanol Withdrawal in Rats (1995)

Prolonged alcohol consumption leads to the development of tolerance to and dependence on ethanol, resulting in a decreased response to the sedative/hypnotic effects of ethanol, and by negative symptomatology following abrupt termination of use. One symptom associated with ethanol withdrawal in humans, as well as laboratory animals, is enhanced susceptibility to seizures. This study investigated the effects of the neurosteroid, 3 alpha-hydroxy-5 alpha-pregnan-20-one (3 alpha-5 alpha-THP), on alterations in seizure sensitivity associated with ethanol withdrawal. 3 alpha-5 alpha-THP is a potent anxiolytic and anticonvulsant agent that acts via selective interactions with GABAA receptors. Extensive evidence suggests that some aspects of ethanol dependence and withdrawal are mediated by alterations in GABAA receptor function. Withdrawal from chronic ethanol exposure elicited dramatic increases in seizure susceptibility in male and female rats. Administration of 3 alpha-5 alpha-THP just before seizure threshold determinations blocked the increased seizure susceptibility induced by ethanol withdrawal. Ethanol-withdrawn animals were protected by 3 alpha-5 alpha-THP at a dose that had no effect on control animal seizure thresholds. Moreover, male and female rats displayed differential responses to the seizure-threshold lowering effects of ethanol withdrawal, as well as the protection by 3 alpha-5 alpha-THP pretreatment. These findings suggest that there are gender differences associated both with ethanol withdrawal as well as the protection by 3 alpha-5 alpha-THP in ethanol-dependent rats.