gebhart/patrepeval huggingface dataset:
P1‐356: Dynamic of Beta‐amyloid deposition in healthy elderly, mild cognitive impairment and Alzheimer's disease: a PiB‐PET longitudinal study (2011)

ß-amyloid (Aß) deposition in Alzheimer's disease (AD) is thought to start while individuals are still cognitively normal with an early phase of fast accumulation and to plateau at the time of cognitive decline. However, only few longitudinal PiB-PET studies have tested this hypothesis with conflicting results. The purpose of this work is to further our understanding of the dynamic of Aß deposition thanks to the use of a large longitudinal neuroimaging cohort. 32 AD patients, 49 mild cognitive impairment (MCI) patients and 103 healthy controls (HC) from the AIBL study8 underwent two PiB-PET scans 18 months apart. For each participant, a parametric map of PiB-PET rate of change was created ((Follow-up scan-Baseline scan)/Follow-up Duration) and entered in a voxelwise 3-way ANCOVA, with clinical status (HC, MCI or AD), clinical outcome (conversion from HC to MCI or AD, or from MCI to AD) and PiB status9 (positive vs. negative) as independent factors. Only a significant effect of the PiB status was found: both PiB+ and PiB- showed a significant increase in Aß deposition, but this increase was significantly higher in PiB+ within a large network. This finding may reflect the fact that PiB- do have slower rates of Aß accumulation, or that they are less numerous to show a significant PiB accumulation. Arguing for the later hypothesis, the distribution of individual rates of neocortical Aß accumulation revealed to be bimodal, and clustering analyses led to a consistent threshold to separate these two subgroups into “PiB non-accumulators” vs. “PiB accumulators”. The voxelwise 3-way ANCOVA was then re-computed with the “PiB accumulators” only and the results were almost unchanged (see Figure). This study highlighted that rates of Aß accumulation increased as the PiB load increased. It thus suggests that Aß deposition does not reach a plateau when cognitive decline occurs but is instead an on-going mechanism over the course of AD. Besides, this is the first study to take into account the fact that Aß accumulation may not increase in all individuals which might offer the possibility to identify the earliest stages of brain Aß accumulation in PiB- accumulators subjects.
Aislamiento y purificación de hormona luteinizante humana: i - extracción a partir de hipófisis (1993)

Este trabajo describe un método para extraer y purificar la hormona luteinizante humana (hLH) a partir de glándulas pituitarias congeladas.\nDe un lote de 47 hipófisis (18.4 g) se separaron las fracciones con actívidad de prolactína (Prl) y de hormona de crecimiento (hGH), quedando lui residuo de glicoproteínas. Una primera cromatografía con CM-Sepharosa permitió separar la\nhormona folículo estimulante (FSH) de las otras dos hormonas, LH y TSH (ürotropina).\nMediante intercambio aniórúco con DEAE-Celulosa se logró separar finalmente la LH de la TSH. La potencia inmunológica de la preparación final de LH dio un valor de 28.169 Ul/\nmg de proteína, valor que se ubica dentro de los más altos reportados para estándares internacionales de referencia para esta hormona. La recuparación global del proceso\nfue de 7.8 mg de LH/100 glándulas equivalente a 19.93 mg de LH/100 g de tejido.
Prognostic Significance of Vitamin D Receptor Polymorphisms in Head and Neck Squamous Cell Carcinoma (2011)

These results suggest that VDR polymorphisms and haplotypes may be associated with prognosis in patients with HNSCC, although the sample size is not large enough to draw definitive conclusions.
Polygon stacks and time reference conversions (2020)

Abstract This paper describes how a time-based planning system, which supports resource constraints, may be extended such that a resource constraint interval does not have to refer to the start- or end-time of the underlying activity but to any linear combination thereof, such as the middle. This way, an activity with multiple resource constraints referring to different time intervals no longer has to be split into sub-activities, which may simplify the planning model and the algorithm. To be able to describe the necessary transformations, we introduce the concept of PolygonStacks and describe the operations which a typical planning engine requires to intersect the sets of consistent timeline entries of all constraints defined on an activity. We then introduce Sliders and Offsets, which allow specifying the constraint intervals in a more generic way as supported in current planning models. Based on this preparation, we can derive two lemmas, which provide the conversions required by Sliders and Offsets. We continue with several conversion examples and point out how to solve the issues which will occur during implementation. A short sketch of the complexity of our current implementation demonstrates that further work on performance should be considered, even though in practice we observe that the bottleneck of calculation remains within profile calculation rather than PolygonStack operations.
SUMO: From Bench to Bedside (2020)

Sentrin/small ubiquitin-like modifier (SUMO) is protein modification pathway that regulates multiple biological processes, including cell division, DNA replication/repair, signal transduction, and cellular metabolism. In this review, we will focus on recent advances in the mechanisms of disease pathogenesis, such as cancer, diabetes, seizure, and heart failure, which have been linked to the SUMO pathway. SUMO is conjugated to lysine residues in target proteins through an isopeptide linkage catalyzed by SUMO-specific activating (E1), conjugating (E2), and ligating (E3) enzymes. In steady state, the quantity of SUMO-modified substrates is usually a small fraction of unmodified substrates due to the deconjugation activity of the family Sentrin/SUMO-specific proteases (SENPs). In contrast to the complexity of the ubiquitination/deubiquitination machinery, the biochemistry of SUMOylation and de-SUMOylation is relatively modest. Specificity of the SUMO pathway is achieved through redox regulation, acetylation, phosphorylation, or other posttranslational protein modification of the SUMOylation and de-SUMOylation enzymes. There are three major SUMOs. SUMO-1 usually modifies a substrate as a monomer; however, SUMO-2/3 can form poly-SUMO chains. The monomeric SUMO-1 or poly-SUMO chains can interact with other proteins through SUMO-interactive motif (SIM). Thus SUMO modification provides a platform to enhance protein-protein interaction. The consequence of SUMOylation includes changes in cellular localization, protein activity, or protein stability. Furthermore, SUMO may join force with ubiquitin to degrade proteins through SUMO-targeted ubiquitin ligases (STUbL). After 20 yr of research, SUMO has been shown to play critical roles in most, if not all, biological pathways. Thus the SUMO enzymes could be targets for drug development to treat human diseases.
Macroscopic Neat Single Wall Carbon Nanotube Fibers (2002)

Measured and predicted properties of individual single wall carbon nanotubes (SWNT) suggest that bulk SWNT materials will exhibit a variety of exceptional properties. Due to the anisotropic nature of SWNTs, fibers are a logical candidate for these objects. The first ever macroscopic fibers, consisting entirely of SWNTs, were successfully produced and characterized. Nanotubes were dissolved at high concentrations (6--10 wt%) in 102% sulfuric acid. The SWNT/sulfuric acid system exhibited unique one-dimensional liquid crystalline phase behavior and interesting rheological characteristics. Fibers were extruded using a wet jet solution-spinning approach into diethyl ether without extensional drawing. Structural analysis showed them to be the highest aligned neat SWNT material produced to-date, with a revealing substructure of coagulated liquid crystalline domains. Additional characterization showed useful electrical and thermal properties and promising mechanical properties. Finally, the Spinning Bob Mixer (SBM), a custom laboratory mixer/extruder, was designed and successfully tested. Various features of the apparatus were demonstrated and shown to be valuable experimental tools for understanding the production of near SWNT fibers. This research has begun the exploration of an interesting and new field of nanotube science by providing a foundation of understanding and enabling future experiments.
Enabling a high capacity and long cycle life for nano-Si anodes by building a stable solid interface with a Li+-conducting polymer (2015)

A new nano-Si/polymer composite with a stable electrochemical interface is synthesized by embedding Si nanoparticles into a Li<sup>+</sup>-conducting polymer matrix to prevent the direct contact of the Si surface with the electrolyte.
Augment or Push? A computational study of Bipartite Matching and Unit Capacity Flow Algorithms. (1997)

We conduct a computational study of unit capacity flow and bipartite matching algorithms. Our goal is to determine which variant of the push-relabel method is most efficient in practice and to compare push-relabel algorithms with augmenting path algorithms. We have implemented and compared three push-relabel algorithms, three augmenting path algorithms (one of which is new), and one augment-relabel algorithm. The depth-first search augmenting path algorithm was thought to be a good choice for the bipartite matching problem, but our study shows that it is not robust. For the problems we study, our implementations of the fifo and lowest-level selection push-relabel algorithms have the most robust asymptotic rate of growth and work best overall. Augmenting path algorithms, although not as robust, on some problem classes are faster by a moderate constant factor. Our study includes several new problem families and input graphs with as many as 5 \\Theta 10 5 vertices.
Three-level cascade of random forests for rapid human detection (2013)

We propose a novel human detection approach that combines three types of center symmetric local binary patterns (CS-LBP) descriptors with a cascade of random forests (RFs). To detect human regions in a low-dimensional feature space, we first extract three types of CS-LBP features from the scanning window of a downsampled saliency texture map and two wavelet-transformed subimages. The extracted CS-LBP descriptors are applied to a three-level cascade of RFs, which combines a series of RF classifiers as a filter chain. The three-level cascade of RFs with CS-LBPs delivers rapid human detection with higher detection accuracy, as compared with combinations of other features and classifiers. The proposed algorithm is successfully applied to various human and nonhuman images from the INRIA dataset, and it performs better than other related algorithms.
Google Docs (2010)

Kippenbrock, Thomas EdD, RN; Holloway, Elaine MSN, RN; Moore, Deborah D. BSN, RNEditor(s): Thede, Linda Q. PhD, RN-BC
CARBON-BASED RAW MATERIALS PLAY KEY ROLES IN TECHNOLOGY OF THE 21ST CENTURY: INDIAN CASE STUDIES (2022)

Coal is a vital carbon-based raw material which is used in the production of various advanced nanomaterials. This particularly holds true for the relevant research and development trends in India. New more environmentally friendly processes are under development with respect to metallurgical coke making and quality enhancement of high-ash Indian coal. Compared with chemical and physical methods, beneficiation of high-ash coal and its combustion by-products with organic liquids (various natural oils) are much more superior in terms of costs, efficiency, and environmental implications. Nanodiamonds have emerged as a key platform for nanoscience and nanotechnology developments. Indian scientists have applied eco-friendly and cost-effective ultrasonic assisted wet-chemical method to low-quality NE Indian coal and the resulting nanodiamond particles could have a wide range of applications in the field of microelectronics, optoelectronics, and biosensing. Also, Indian scientists have been working on ultrasonic-assisted chemical synthesis of activated carbon from low-quality subbituminous coal and its preliminary evaluation towards supercapacitor applications. This article shows that coal is a versatile and valuable raw material which should be saved for future generations at all costs.
Ultra-High Gradient Dielectric Wakefield Accelerator Experiments (2006)

Ultra‐high gradient dielectric wakefield accelerators are a potential option for a linear collider afterburner since they are immune to the ion collapse and electron/positron asymmetry problems implicit in a plasma based afterburner. The first phase of an experiment to study the performance of dielectric Cerenkov wakefield accelerating structures at extremely high gradients in the GV/m range has been completed. The experiment took advantage of the unique SLAC FFTB electron beam and its ultra‐short pulse lengths and high currents (e.g., σz = 20 μm at Q = 3 nC). The FFTB electron beam was successfully focused down and sent through short lengths of fused silica capillary tubing (ID = 200 μm / OD = 325 μm). The pulse length of the electron beam was varied to produce a range of electric fields between 2 and 20 GV/m at the inner surface of the dielectric tubes. We observed a sharp increase in optical emissions from the capillaries in the middle part of this surface field range which we believe indicates the transition between sustainable field levels and breakdown. If this initial interpretation is correct, the surfaced fields that were sustained equate to on axis accelerating field of several GV/m. In future experiments being developed for the SLAC SABER and BNL ATF we plan to use the coherent Cerenkov radiation emitted from the capillary tube as a field strength diagnostic and demonstrate GV/m range particle energy gain.
Effect of Ball-Milling on 3-V Capacity of Lithium−Manganese Oxospinel Cathodes (2001)

Ball-milling for a sufficient period of time of lithium−manganese oxide spinels, prepared either by a sol−gel method or by solid-state reaction, gave cathode materials of a lithium cell with excellent capacity retention in the 3-V range at room temperature and elevated temperatures despite an apparent Jahn−Teller distortion. In a 50-cycle test with 0.5 mA/cm2, a sample ball-milled for 1 h gave a constant capacity of 122 mAh/g at a constant voltage 2.9 V versus lithium. X-ray diffraction and transmission electron microscopy were performed on the ball-milled spinel powders; they were found to contain significant strain and to consist of nanometer-scale grains. Furthermore, partial oxidation of manganese ions took place during the ball-milling process.
CONTRÔLE DES FLUCTUATIONS BASSES FRÉQUENCES DANS UN LASERÀ CASCADES QUANTIQUES SOUMISÀ DES TEMPÉRATURES CRYOGÉNIQUES (2018)

International audience
UDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients (2004)

The risk of ER- breast cancer tumors may vary by UGT or SULT genotype. Further, plasma estradiol and testosterone concentrations in breast cancer patients may differ depending on some UGT and SULT genotypes.
On the organic/inorganic interface between mesoporous SBA-16 silica and its structural directing polymer: a combined FT-IR and solid state NMR study (2011)

In the last years large attention was devoted to the synthesis and characterization of SBA-16 material focusing the interest on the formation mechanisms of copolymer micelles which drive the organization of the final siliceous mesostructure. However, there are relatively few reports on the block copolymer-silica self-assembly interaction phenomena which mainly occur at solid state and which help to understand how the copolymer is organized in the final solid sample. The physico-chemical properties at the interface between silica framework and triblock EO106PO70EO106 co-polymer in a SBA-16 material were investigated. In particular, the combination of infrared spectroscopy with solid state NMR allowed to obtain complementary information on how the surfactant co-polymer interacts with the SBA-16 surface silanols in the presence or absence of physisorbed water and to follow the evolution of the structural organization of the co-polymer, which depends on the hydration degree of the SBA-16 sample.
Influence of the Spatial and Temporal Interaction Between Diesel Pilot and Directly Injected Natural Gas Jet on Ignition and Combustion Characteristics (2018)

In this paper, pilot-ignited high pressure dual-fuel combustion of a natural gas jet is investigated on a fundamental basis by applying two separate single-hole injectors to a rapid compression expansion machine (RCEM). A Shadowgraphy system is used for optical observations, and the combustion progress is assessed in terms of heat release rates (HRRs). The experiments focus on the combined influence of injection timing and geometrical jet arrangement on the jet interaction and the impact on the combustion process. In a first step, the operational range for successful pilot self-ignition and transition to natural gas jet combustion is determined, and the restricting phenomena are identified by analyzing the shadowgraph images. Within this range, the combustion process is assessed by evaluation of ignition delays and HRRs. Strong interaction is found to delay or even prohibit pilot ignition, while it facilitates a fast and stable onset of the gas jet combustion. Furthermore, it is shown that the HRR is governed by the time of ignition with respect to the start of natural gas injection—as this parameter defines the level of premixing. Evaluation of the time of gas jet ignition within the operability map can therefore directly link a certain spatial and temporal interaction to the resulting heat release characteristics. It is finally shown that controlling the HRR through injection timing variation is limited for a certain angle between the two jets.
Prognostic Factors and Percutaneous Nephrolithotomy Morbidity: A Multivariate Analysis of a Contemporary Series Using the Clavien Classification (2008)

The dedicated setting for percutaneous nephrolithotomy at our center resulted in decreased operative time, more uneventful procedures and decreased hospitalization time. The modified Clavien morbidity score is a reliable tool for more objective outcome comparisons after renal stone treatment.
Brain pharmacokinetics of neurotoxin-loaded PLA nanoparticles modified with chitosan after intranasal administration in awake rats (2013)

These results suggest that NPs modified with chitosan have better brain targeting efficiency and are a promising approach for i.n. delivery of large hydrophilic peptides and proteins in improving the treatment of central nervous system (CNS) disorders.
Antibiotic susceptibility of intra-abdominal infection isolates from Indian hospitals during 2008 (2010)

A total of 542 clinical isolates of aerobic Gram-negative bacilli from intra-abdominal infections were collected during 2008 from seven hospitals in India participating in the Study for Monitoring Antimicrobial Resistance Trends (SMART). Isolates were from various infection sources, the most common being gall bladder (30.1 %) and peritoneal fluid (31.5 %), and were mostly hospital-associated isolates (70.8 %) as compared to community-acquired (26.9 %). The most frequently isolated pathogens were Escherichia coli (62.7 %), Klebsiella pneumoniae (16.7 %) and Pseudomonas aeruginosa (5.3 %). Extended-spectrum beta-lactamase (ESBL) rates in E. coli and K. pneumoniae were very high, at 67 % and 55 %, respectively. Most isolates exhibited resistance to one or more antibiotics. The most active drugs were generally ertapenem, imipenem and amikacin. However, hospital-acquired isolates in general, as well as ESBL-positive isolates, exhibited lower susceptibilities than community-acquired isolates. Further surveillance monitoring of intra-abdominal isolates from India is recommended.
HER2/neu uses Akt to suppress retinoic acid response element binding activity in MDA-MB-453 breast cancer cells (2003)

We previously demonstrated that HER2/neu prevents all trans-retinoic acid (ATRA) from inducing growth inhibition in MDA-MB-453 breast cancer cells. For ATRA to induce growth inhibition, it needs to bind to retinoic acid receptors and modulate gene transcription via retinoic acid response elements (RAREs). We hypothesized that HER2/neu suppresses RARE binding activity to prevent ATRA from inducing growth arrest in breast cancer cells. Electrophoretic mobility shift assays showed that when HER2/neu was inhibited by the trastuzumab antibody, RARE binding activity increased, indicating that HER2/neu suppresses RARE binding. Since trastuzumab also decreased Akt activity, we determined whether Akt regulates RARE binding activity. Compared to parental MDA-MB-453 cells, MDA-MB-453 cells transfected with a dominant negative Akt mutant (MDA-MB-453/DN-Akt) had higher RARE binding activity. However, trastuzumab did not further increase RARE binding activity in MDA-MB-453/DN-Akt cells. These data indicate that HER2/neu predominantly uses Akt to suppress RARE binding activity, which may be one mechanism by which HER2/neu induces ATRA resistance in breast cancer cells.
UV photodissociation of the van der Waals dimer (CH3I)2 revisited: Pathways giving rise to ionic features (2005)

The CH(3)I A-state-assisted photofragmentation of the (CH(3)I)(2) van der Waals dimer at 248 nm and nearby wavelengths has been revisited experimentally using the time-of-flight mass spectrometry with supersonic and effusive molecular beams and the "velocity map imaging" technique. The processes underlying the appearance of two main (CH(3)I)(2) cluster-specific features in the mass spectra, namely, I(2)(+) and translationally "hot" I(+) ions, have been studied. Translationally hot I(+) ions with an average kinetic energy of 0.94+/-0.02 eV appear in the one-quantum photodissociation of vibrationally excited I(2)(+)((2)Pi(32,g)) ions (E(vib)=0.45+/-0.11 eV) via a "parallel" photodissociation process with an anisotropy parameter beta=1.55+/-0.03. Comparison of the images of I(+) arising from the photoexcitation of CH(3)I clusters versus those from neutral I(2) shows that "concerted" photodissociation of the ionized (CH(3)I)(2)(+) dimer appears to be the most likely mechanism for the formation of molecular iodine ion I(2)(+), instead of photoionization of neutral molecular iodine.
Trombocitopenia severa como manifestación de un tumor testicular de células germinales con metástasis cardíaca intracavitaria (2014)

Se describe el caso de un hombre de 24 anos que se pre-senta con Purpura trombocitopenico, cuyo estudio eco-cardiografico y tomografia computada demostro masa tumoral ocupando las cavidades derechas. Se evidencio posteriormente un tumor testicular izquierdo con com-ponentes de seminoma y teratoma. Se reseco el tumor testicular y posteriormente el tumor intracardiaco, con normalizacion del recuento plaquetario.
Matlab / simulink based study of photovoltaic cells / modules / array and their experimental verification (2010)

A Matlab-Simulink based simulation study of PV cell/PV module/PV array is carried out and presented in this paper. The simulation model makes use of basic circuit equations of PV solar cell based on its behaviour as diode and comprehensive behavioural study is performed under varying conditions of solar insolation, temperature, varying diode model parameters, series and shunt resistance etc. The study is helpful in outlining the principle and intricacies of PV cell/modules and may be used to verify the impact of different topologies and control techniques on the performance of different types of PV systems. The PV module/Array performance is immensely marred by shading effect and its P-V characteristics exhibit multiple maxima. The Matlab/simulink based study therefore also points out significance of locating maximum power point for a given Module/Array. An experimental verification is also carried out in the lab by developing a PC based data acquisition system, which is also briefly discussed. Copyright © 2010 International Energy and Environment Foundation - All rights reserved.