gebhart/patrepeval huggingface dataset:
Neonatal tolerance induction by class II alloantigens activates IL-4-secreting, tolerogen-responsive T cells. (1990)

Neonatally induced tolerance of class II MHC alloantigens in mice of the A/J strain background is achieved without evident clonal deletion, because lymphoid cells from tolerant animals proliferate in mixed lymphocyte reactions against tolerogen-bearing stimulators. However, the pattern of lymphokines produced in bulk cultures by these tolerogen-reactive cells is unusual in that, unlike lymphocytes from nontolerant normal mice, lymphocytes from tolerant mice produce measurable amounts of IL-4 when stimulated with tolerogen. Using limit dilution analysis, we have determined that the ability to detect IL-4 in bulk cultures is caused by a high frequency of precursors of Ag-specific IL-4 secreting (pIL-4) cells among tolerant, but not normal, responder lymphocytes. Moreover, after repeated in vitro exposure to class II alloantigens, and after in vivo grafting with class II-disparate skin, the frequency of pIL-4 cells rises among lymphocytes from normal mice, eventually reaching levels similar to those found in class II tolerant mice. Because in normal mice a high frequency of class II-reactive pIL-4 cells reflects the "primed" state, we conclude that a subset of T cells that resemble Th2 cells is similarly primed in neonatally tolerized mice. We propose that this priming is achieved by the neonatal inoculation of semiallogeneic bone marrow cells. Because no expansion in the clone size of tolerogen-specific precursors of Ag-specific IL-2-secreting T cells (pIL-2) is observed among tolerant animals, and because the pIL-2 cells from tolerant mice are incapable of differentiating into cytotoxic and delayed hypersensitivity effector cells, we further propose that the precociously primed pIL-4 cells function as "suppressor" cells, helping to maintain the tolerant state.
Pharmacokinetic and pharmacogenetic analysis of immunosuppressive agents after laparoscopic sleeve gastrectomy (2017)

Dose modification of immunosuppressants post-LSG may not be necessary aside from standard therapeutic drug monitoring.
A low power Ka-band SiGe HBT VCO using line inductors (2004)

An integrated low power, low phase noise Ka-band differential voltage-controlled oscillator (VCO) is developed in a 0.12-/spl mu/m 200 GHz SiGe HBT technology. The use of line inductors instead of transmission lines is demonstrated to be feasible in LC-tuned resonators for Ka-band applications. The VCO operates on 1.6 V and dissipates 3.7 mW of power. A phase noise of -99 dBc/Hz at 1 MHz offset from the carrier frequency of 33 GHz is achieved, together with a VCO figure-of-merit of -183.7 dBc/Hz.
A Fully Fabric-Based Bidirectional Soft Robotic Glove for Assistance and Rehabilitation of Hand Impaired Patients (2017)

This letter presents a fully fabric-based bidirectional soft robotic glove designed to assist hand impaired patients in rehabilitation exercises and performing activities of daily living. The glove provides both active finger flexion and extension for hand assistance and rehabilitative training, through its embedded fabric-based actuators that are fabricated by heat press and ultrasonic welding of flexible thermoplastic polyurethane-coated fabrics. Compared to previous developed elastomeric-based actuators, the actuators are able to achieve smaller bend radius and generate sufficient force and torque to assist in both finger flexion and extension at lower air pressure. In this letter, experiments were conducted to characterize the performances of the glove in terms of its kinematic and grip strength assistances on five healthy participants. Additionally, we present a graphical-user interface that allows user to choose the desired rehabilitation exercises and control modes, which include button-controlled-assistive mode, cyclic movement training, intention-driven task-specific training, and bilateral rehabilitation training.
High antitrypanosomal activity of plant-derived sulphur-containing amides (2010)

Chagas disease, caused by Trypanosoma cruzi, represents an important public health problem in endemic geographic regions in Middle and South America, affecting 15 million infected people. Treatment options are still limited due to the toxicity of available drugs, parasite resistance and poor drug activity during the chronic phase of the disease. In this study, we investigated the in vitro antitrypanosomal activity of 15 tropical plant-derived compounds with the aim of finding new drug candidates. Three novel sulphur-containing amides (methyldambullin, methylgerambullin and sakambullin) showed promising antitrypanosomal activities, with 50% effective concentrations (EC₅₀ values) after 72 h exposure of 1.7, 1.23 and 5.18 μM, respectively, compared with EC₅₀ values for amphotericin B and benznidazole of 0.71 μM and 30.89 μM, respectively.
Network-coding-based hybrid ARQ scheme for mobile relay networks (2010)

A network coding based hybrid automatic retransmission request (HARQ) scheme is proposed for mobile relay systems. The simulation results of the relay system using a 1/2 recursive systematic convolution code over binary phase shift keying show that the proposed scheme provides a definite improvement in throughput performance compared to existing relay-based HARQ (relay-HARQ) schemes.
IL-18 Serum Concentration Is Markedly Elevated in Acute EBV Infection and Can Serve as a Marker for Disease Severity (2012)

Epstein Barr virus (EBV)-related diseases encompass both acute infections that result in acute infectious mononucleosis and chronic infections that result in lymphoproliferative malignant diseases. While classical inflammatory parameters such as C-reactive protein (CRP) have proven their usefulness during bacterial and fungal infections, they are often low and nondiscriminatory in viral infections. Here, we show that IL-18 is markedly elevated during acute EBV infections and EBV-associated diseases, while ferritin concentrations are also elevated during acute EBV infection and correlate with IL-18. Therefore, IL-18 and ferritin may represent infection markers for viral infections such as EBV, similar to CRP for bacterial infections.
In-silico testing of new pharmacology for restoring inhibition and human cortical function in depression (2023)

Abstract Reduced inhibition by somatostatin-expressing interneurons is associated with depression. Administration of positive allosteric modulators of α5 subunit-containing GABA A receptor (α5-PAM) that selectively target this lost inhibition exhibit antidepressant and pro-cognitive effects in rodent models of chronic stress. However, the functional effects of α5-PAM on the human brain in vivo are unknown, and currently cannot be assessed experimentally. We modeled the effects of α5-PAM on tonic inhibition as measured in human neurons, and tested in silico α5-PAM effects on detailed models of human cortical microcircuits in health and depression. We found that α5-PAM effectively recovered impaired cortical processing as quantified by stimulus detection metrics, and also recovered the power spectral density profile of the microcircuit EEG signals. We performed an α5-PAM dose response and identified simulated EEG biomarker candidates. Our results serve to de-risk and facilitate α5-PAM translation and provide biomarkers in non-invasive brain signals for monitoring target engagement and drug efficacy.
Capacity scaling laws in MIMO relay networks (2006)

The use of multiple antennas at both ends of a wireless link, popularly known as multiple-input multiple-output (MIMO) wireless, has been shown to offer significant improvements in spectral efficiency and link reliability through spatial multiplexing and space-time coding, respectively. This paper demonstrates that similar performance gains can be obtained in wireless relay networks employing terminals with MIMO capability. We consider a setup where a designated source terminal communicates with a designated destination terminal, both equipped with M antennas, assisted by K single-antenna or multiple-antenna relay terminals using a half-duplex protocol. Assuming perfect channel state information (CSI) at the destination and the relay terminals and no CSI at the source, we show that the corresponding network capacity scales as C = (M/2) log(K) + O(1) for fixed M, arbitrary (but fixed) number of (transmit and receive) antennas N at each of the relay terminals, and K rarr infin. We propose a protocol that assigns each relay terminal to one of the multiplexed data streams forwarded in a "doubly coherent" fashion (through matched filtering) to the destination terminal. It is shown that this protocol achieves the cut-set upper bound on network capacity for fixed M and K rarr infin (up to an O(1)-term) by employing independent stream decoding at the destination terminal. Our protocol performs inter-stream interference cancellation in a completely decentralized fashion, thereby orthogonalizing the effective MIMO channel between source and destination terminals. Finally, we discuss the case where the relay terminals do not have CSI and show that simple amplify-and-forward relaying, asymptotically in K, for fixed M and fixed N ges 1, turns the relay network into a point-to-point MIMO link with high-SNR capacity C = (M/2) log(SNR) + O(1), demonstrating that the use of relays as active scatterers can recover spatial multiplexing gain in poor scattering environments
ChemInform Abstract: Syntheses of Several Cyclopentano‐Monoterpene Lactones Using 1,3‐ Dioxin Vinylogous Ester. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The diagnostic utility of elevation in cerebrospinal fluid β 2 ‐microglobulin in HIV‐1 dementia (1992)

We measured serum and CSF beta 2-microglobulin (beta 2M) levels in HIV-1 seropositive individuals with and without dementia to determine the frequency and diagnostic utility of elevation of CSF beta 2M. We compared 34 samples from 27 patients with HIV-1 dementia with 110 samples from 54 HIV-1 seropositive participants in the Multicenter AIDS Cohort Study, none of whom had progressive dementia. Neurosyphilis and CNS opportunistic processes were excluded in all subjects. We stratified the nondemented subjects by duration of HIV seropositivity and peripheral blood CD4 count. Compared with the nondemented group, demented subjects had significantly higher CSF total protein, IgG%, and CSF albumin/serum albumin ratios. A highly significant association was found between elevated CSF beta 2M and reduced CD4 count (p less than 0.0001). No significant differences were noted between the demented and nondemented groups in CSF WBC count or in the frequency of CSF HIV-1 isolation. The mean CSF beta 2M was 1.9 mg/l in the nondemented subjects compared with 4.2 mg/l in those with dementia (p less than 0.0001). We derived a cutoff of 3.8 mg/l from the distribution of CSF beta 2M in the nondemented group. The determination of CSF beta 2M had a sensitivity of 44%, specificity of 90%, and a positive predictive value of 88% for diagnosis of HIV dementia when compared with nondemented subjects with CD4 counts less than 200. In those without dementia, there was a strong correlation between serum and CSF beta 2M (r = 0.50, p less than 0.0001), but in demented subjects CSF beta 2M was elevated independently of serum levels, suggesting that CSF beta 2M is produced within the brain in HIV dementia. In the absence of CNS opportunistic processes, elevated CSF beta 2M greater than 3.8 mg/l is a clinically useful marker for HIV dementia.
Amphiphilic Phospholipid-Based Riboflavin Derivatives for Tumor Targeting Nanomedicines (2016)

Riboflavin (RF) is an essential vitamin for cellular metabolism. Recent studies have shown that RF is internalized through RF transporters, which are highly overexpressed by prostate and breast cancer cells, as well as by angiogenic endothelium. Here, we present an optimized synthesis protocol for preparing tailor-made amphiphilic phospholipid-based RF derivatives using phosphoramidite chemistry. The prepared RF amphiphile-RfdiC14-can be inserted into liposome formulations for targeted drug delivery. The obtained liposomes had a hydrodynamic size of 115 ± 5 nm with narrow size distribution (PDI 0.06) and a zeta potential of -52 ± 3 mV. In vitro uptake studies showed that RfdiC14-containing liposomes were strongly internalized in HUVEC, PC3, and A431 cells, in a specific and transporter-mediated manner. To assess the RF targeting potential in vivo, an amphiphile containing PEG spacer between RF and a lipid was prepared-DSPE-PEG-RF. The latter was successfully incorporated into long-circulating near-infrared-labeled liposomes (141 ± 1 nm in diameter, PDI 0.07, zeta potential of -33 ± 1 mV). The longitudinal μCT/FMT biodistribution studies in PC3 xenograft bearing mice demonstrated similar pharmacokinetics profile of DSPE-PEG-RF-functionalized liposomes compared to control. The subsequent histological evaluation of resected tumors revealed higher degree of tumor retention as well as colocalization of targeted liposomes with endothelial cells emphasizing the targeting potential of RF amphiphiles and their utility for the lipid-containing drug delivery systems.
THE EFFECT OF ANTILYMPHOCYTE SERUM, FRACTIONATED DONOR BONE MARROW, AND CYCLOSPORINE ON RENAL ALLOGRAFT SURVIVAL IN MONGREL DOGS (1991)

The effect of combined treatment with antilymphocyte serum, fractionated donor bone marrow, and a limited course of cyclosporine on renal allograft survival in mongrel dogs was examined. Recipients were treated with ALS from day -5 to day +7, relative to transplantation on day 0 with an MLR-mismatched donor. Fractionated donor bone marrow cells (BMFr3) obtained by density gradient separation were infused 3-7 days after ALS treatment. CsA treatments were begun either 3-7 days after ALS plus BMFr3 infusion or 3-7 days after treatments with ALS alone. Extended allograft survival was achieved at all CsA doses in BMFr3-infused, ALS-treated recipients. Allografts were sustained throughout the CsA treatment period without rejection in the majority of recipients (6 of 8) receiving ALS plus BMFr3 and CsA at 20 Mg/kg/day for 60 days. By contrast, few grafts were sustained through 30 days of treatment with CsA at 3.2 (1 of 12) or 10 mg/kg/day (2 of 9) in ALS plus BMFr3-treated recipients. Cyclosporine treatment was ineffective at all doses in augmenting allograft prolongation in ALS-treated recipients that did not receive BMFr3. Nearly all (6 of 7) long-term survivors (greater than 180 days) were BMFr3-treated. Peripheral blood lymphocytes or bone marrow cells of these long-term survivors proliferated normally in response to Con A and PWM, and were MLR responsive to third-party cells but did not have reduced MLR responsiveness to donor alloantigen in all cases. These long-term survivors promptly rejected third-party renal allografts without adverse effects on the original transplant's function. These results show that long-term renal allograft survival with specific unresponsiveness to the donor can result from the combined treatment with ALS plus donor BMFr3 and a limited course of CsA.
Hydration and setting of cements : proceedings of the International RILEM Workshop on Hydration and Setting organized by the Laboratoire de Recherche sur la Réactivité des Solides, Université de Bourgogne, France, Dijon, July 3-5,1991 (1992)

P. Barret and cement chemistry, H.F.W. Taylor. Part 1: Early hydration of calcium silicates. Part 2: Silicate anion structure. Part 3: Hydration of other constituents of cements. Part 4: Hydration and setting. Part 5: Particle interactions during hydration and setting. Part 6: Rheology of suspensions. Part 7: Strength development. Part 8: Hydration and microstructure.
PLAY!: Sound Toys for Non-Musicians (2002)

Computer Music Journal - Volume 26, Number 3, Fall 2002
New Insights into the Role of Protein Prenylation and Processing in Plant Development, Phytohormone Signaling, and Secondary Metabolism (2015)

Flag-Tag, GST-Pull Down .................................................................... 158 6.4 Conclusion ............................................................................................ 163 Acknowledgements ........................................................................................ 163 Keywords ....................................................................................................... 164 References ...................................................................................................... 164Prostate cancer is the most common cancer in western men and causes the most frequent cancer-related death after lung cancer. The incidence and death rates are gradually increasing and it is estimated that in the USA alone there will be 218,890 new cases and 27,050 deaths in 2007 (Jemal et al., 2007). There are several risk factors for prostate cancer such as age, family history and ethnicity. Prostate cancer occurs mostly in men aged more than 65 years old and African Americans have the highest incidence and mortality rate compared to European and Caucasian American men (Powell, 2007). In addition, a diet that is high in fat content is suspected to increase the likelihood of being diagnosed with prostate cancer (Stacewicz-Sapuntzakis et al., 2008).
Covid-19 pandemic impact on colonoscopy service and suggestions for managing recovery (2020)

<b>Background and aim</b> As the post-peak phase of the epidemic is approaching, there is an urgent need of an action plan to help resume endoscopy activity. To manage the Covid-19 pandemic-imposed backlog of postponed colonoscopy examinations, an efficient approach is needed. The practice of on-demand sedation with benzodiazepines and/or opiates will allow most patients to complete a water-aided examination with minimal or no sedation. Other methods reported to minimize patient discomfort during colonoscopy can be used, in addition to water-aided techniques. Unsedated or minimally sedated patients who do not require recovery or require a shorter one allow rapid turnaround. The practice obviates the need for assistance with deep sedation from anesthesiologists, who may be in short supply. Trainee education in water-aided colonoscopy has been demonstrated to confer benefits. This review provides some insights into the impact of Covid-19 on endoscopy services, challenges ahead, and possible solutions to help recovery of colonoscopy work and training.
COTS BGA Thermal Fatigue Test for Avionics Applications (2003)

The objectives of the present studies are to design and test representative commercial off-the-shelf plastic encapsulated microcircuits, including various types of ball grid array (BGA) components, chip scale package, and flip chip over military thermal environment. The approach is to demonstrate the solder joint reliability performance of these components through the design of an electrical daisy-chain pattern printed wiring board (PWB) assembly test vehicle (TV), in which the design and manufacturing variables are included. The variables, including the types of PWBs, conformal coating, and BGA underfilled materials, with each having either two or three levels of variation are used to address test criteria and to construct 12 different types of TV configurations. All TV configurations are then subjected to temperature cycling tests (−55°C to +125°C) while continuously monitoring solder joint integrity. Based on the measured results, a destructive physical analysis is then conducted to further isolate the failure locations and determine the failure mechanisms of the solder joints. Based on the lesson-learned from the above TV, a second TV (defined as TV2) has been designed, constructed and tested. The four selected parameters in TV2 are BGA under-fill materials, conformal coating, solder pad sizes on PWB, and BGA rework, with each also having either two or three levels of variation. Test results from these two groups of TVs indicate that the influence of these design and manufacturing parameters on fatigue life is dependent on the particular package, in some instances improving the fatigue life tenfold. All these test results are recommended to be used for calibrating BGA solder joint thermal fatigue life prediction models, which will be presented in other publications.
Markerless motion tracking and correction for PET, MRI, and simultaneous PET/MRI (2019)

As simultaneous PET/MRI systems have become available for clinical use, an increasing demand for accurate motion tracking and MC in PET/MRI scans has emerged. The presented markerless motion tracker facilitate this demand.
Copper Salt‐Catalyzed Azide‐[3 + 2] Cycloadditions of Ynamides and Bis‐Ynamides (2006)

Abstract A one‐pot synthesis of amide‐substituted triazoles from alkyl bromides and ynamides is described here along with syntheses of novel bis‐ynamides and their applications in [3+2] cycloadditions with azides to construct unique bis‐triazoles.
Double image encryption using double pixel scrambling and linear canonical transform (2013)

A novel method of double image encryption is proposed, by utilizing random phase encoding in the LCT domain to encrypt two images into one encrypted image with stationary white distribution. By proper application of keys i.e. order of transform and random phase mask. The images can be recovered without any loss of information. The phase based image is more sensitive to keys and disturbances than amplitude based image. The image pixel scrambling operation enhances the quality of the decrypted image when noise occurs and linear canonical transform improves authentication. Numerical simulations have been done to prove the security and validity of the proposed method.
Tracking the Invisible: Privacy-Preserving Contact Tracing to Control\n the Spread of a Virus (2020)

Today, tracking and controlling the spread of a virus is a crucial need for\nalmost all countries. Doing this early would save millions of lives and help\ncountries keep a stable economy. The easiest way to control the spread of a\nvirus is to immediately inform the individuals who recently had close contact\nwith the diagnosed patients. However, to achieve this, a centralized authority\n(e.g., a health authority) needs detailed location information from both\nhealthy individuals and diagnosed patients. Thus, such an approach, although\nbeneficial to control the spread of a virus, results in serious privacy\nconcerns, and hence privacy-preserving solutions are required to solve this\nproblem. Previous works on this topic either (i) compromise privacy (especially\nprivacy of diagnosed patients) to have better efficiency or (ii) provide\nunscalable solutions. In this work, we propose a technique based on private set\nintersection between physical contact histories of individuals (that are\nrecorded using smart phones) and a centralized database (run by a health\nauthority) that keeps the identities of the positive diagnosed patients for the\ndisease. Proposed solution protects the location privacy of both healthy\nindividuals and diagnosed patients and it guarantees that the identities of the\ndiagnosed patients remain hidden from other individuals. Notably, proposed\nscheme allows individuals to receive warning messages indicating their previous\ncontacts with a positive diagnosed patient. Such warning messages will help\nthem realize the risk and isolate themselves from other people. We make sure\nthat the warning messages are only observed by the corresponding individuals\nand not by the health authority. We also implement the proposed scheme and show\nits efficiency and scalability via simulations.\n