gebhart/patrepeval huggingface dataset:
Zosuquidar restores drug sensitivity in P-glycoprotein expressing acute myeloid leukemia (AML) (2008)

These in vitro studies suggest that zosuquidar may be an effective adjunct to cytotoxic chemotherapy for AML patients whose blasts express P-gp, especially for older patients.
Inhibition by Iodide of the Cholinergic Stimulation of Prostaglandin Synthesis in Dog Thyroid* (1979)

Iodide is shown to inhibit the cholinergic stimulation of prostaglandin E2 (PGE2) and F2a(PGF2a) synthesis in dog thyroid slices. The inhibitory effect of iodide was already detectable at 1 μM and reached its maximal level at 10 μM. At this concentration, iodide inhibited the carbamylcholine-stimulated release of PGE2 and PGF2a by 59% and 73%, respectively (eight experiments). The effect of iodide was neither immediate nor rapidly reversed after a change of incubation medium. The unstimulated release of PGE2 and PGF2a and the stimulation by epinephrine and ionophore A23187 were not modified by iodide in concentrations up to 0.1 mM. The effect of iodide was suppressed in the presence of methimazole (0.1 mM) but not NaC104 (2 mM). Iodide (0.1 mM) did not inhibit the stimulation by carbamylcholine of PGF2a and PGE2 release by rat pancreas in vitro. These data demonstrate a new action of iodide on the thyroid and establish a link among iodide metabolism, PG synthesis, and cholinergic action in the dog thyroid.
Enzyme activity electrophoresis: Development and applications (1989)

The development of rocket enzyme activity electrophoresis for the detection and quantification of various proteinases, lipases and pectinases is presented. Rocket enzyme activity electrophoresis is more sensitive than the radial diffusion assay and often enables distinction between qualitatively different enzymes present in the same samples, whereas the radial diffusion assay only provides information on the overall enzyme activity. However, calibration and optimization of the enzyme activity electrophoretic assay have to be performed for each new enzyme-substrate system to be analyzed. Some of the common pitfalls in the development of new enzyme activity electrophoretic assays are presented. Enzyme activity electrophoresis can be applied in combination with other electrophoretic assays. Particularly the combination of enzyme activity electrophoresis with various immunoelectrophoretic methods can provide detailed information on the enzymes studies.
Berry’s phase and persistent charge and spin currents in textured mesoscopic rings (1990)

We consider the motion of electrons through a mesoscopic ring in the presence of a classical, static, inhomogeneous, magnetic field. Zeeman interaction between the electron spin and this texture couples spin and orbital motion, and results in a Berry phase. As a consequence, the system supports persistent equilibrium spin and charge currents, even in the absence of conventional electromagnetic flux through the ring. We mention the possibility of analogous persistent mass and spin currents in normal $^{3}\mathrm{He}$.
Polarimetric optical fibers with elliptical liquid-crystal core (2002)

We present experimental data on polarization properties of the light propagating in an anisotropic elliptical fiber with a liquid-crystal core in view of potential applications for use in polarimetric fiber-optic sensors.
A System Solution for High-Performance, Low Power SDR (2005)

One central challenge in the realization of Software De-fined Radio (SDR) is to provide a programmable solution that meets the challenging high-performance, low-power requirements, while providing an efficient software devel-opment interface. In this paper, we present an overview of a fully programmable multi-core SIMD architecture for SDR. Our solution can support 2Mbps W-CDMA at about 270mW, and 24Mbps 802.11a at about 370mW in 90nm technology. This high computational efficiency is achieved by exploiting the vector characteristics of the algorithms, through a unique multi-core architecture that consists of tightly coupled scalar and wide SIMD pipelines. In addi-tion, we present a software design flow that supports effi-cient DSP programming and implementation through a set of signal processing extensions to C, referred to as SPEX. 1
Haptic Data Reduction for Time-delayed Teleoperation Using the Input-to-State Stability Approach (2019)

There are two major challenges for time-delayed teleoperation with haptic feedback over packet-switched networks: the high packet rate of the bidirectionally exchanged haptic data and the maintenance of system stability in the presence of communication delay. Concerning the former, ensuring the required high update rate for haptic information (≥1 kHz) requires significant transmission resources. Regarding the latter, stability-ensuring control architectures must be employed to guarantee system stability. In order to achieve both stable system design and efficient haptic data communication, joint consideration of haptic data reduction and stability-ensuring control is necessary for teleoperation systems. In this paper, we propose a novel haptic data communication solution for time-delayed teleoperation which integrates the perceptual deadband-based haptic data reduction method with the input-to-state stability (ISS) controller. In particular, the proposed ISS-based haptic data reduction solution is able to reduce the haptic packet rate while preserving the system stability in the presence of constant communication delay. Experimental results show that our approach reduces the overall haptic data by up to 80% without introducing significant perceptual distortion. Compared with the state-of-the-art time-domain passivity approach-based haptic data reduction approach [1], our method provides an improved user experience at a similar packet rate when the delay is less than 100 ms. Moreover, the experimental results also indicate that a joint optimization of communication and control may achieve the best possible teleoperation quality when the requirements of network quality of service and user experience vary.
Spectrum Pooling in MmWave Networks: Opportunities, Challenges, and Enablers (2016)

Motivated by the specific characteristics of mmWave technologies, we discuss the possibility of an authorization regime that allows spectrum sharing between multiple operators, also referred to as spectrum pooling. In particular, considering user rate as the performance measure, we assess the benefit of coordination among networks of different operators, study the impact of beamforming at both base stations and user terminals, and analyze the pooling performance at different frequency carriers. We also discuss the enabling spectrum mechanisms, architectures, and protocols required to make spectrum pooling work in real networks. Our initial results show that, from a technical perspective, spectrum pooling at mmWave has the potential to use the resources more efficiently than traditional exclusive spectrum allocation to a single operator. However, further studies are needed in order to reach a thorough understanding of this matter, and we hope that this article will help stimulate further research in this area.
Supplementary Figure S6 from Targeting CD20<sup>+</sup> Aggressive B-cell Non–Hodgkin Lymphoma by Anti-CD20 CAR mRNA-Modified Expanded Natural Killer Cells <i>In Vitro</i> and in NSG Mice (2023)

&lt;p&gt;Supplementary Fig.S6: The purified expanded PBNK cells have higher activating receptors expression PBNK cells were expanded ex vivo by co-culturing PBMC with irradiated geK562 feeder cell lines in the presence of 40 U/mL IL-2 for 14 days and isolated by depleting CD3+ T cells. NK cells were stained with indicated monoclonal antibodies immediately after isolation. Cell surface expression on viable cells is shown by flow cytometry analysis.&lt;/p&gt;
Biopolymer ‐Based Nanocomposites for Environmental Applications (2017)

This chapter contains sections titled: Introduction Biopolymers: Chemistry and Properties Preparation Techniques of Polymer Nanocomposites Characterization of Polymer Nanocomposites Environmental Application of Biopolymers-Based Nanocomposites Conclusion and Future Aspects
Securing Heterogeneous IoT with Intelligent DDoS Attack Behavior Learning (2017)

The rapid increase of diverse Internet of things (IoT) services and devices has raised numerous challenges in terms of connectivity, computation, and security, which networks must face in order to provide satisfactory support. This has led to networks evolving into heterogeneous IoT networking infrastructures characterized by multiple access technologies and mobile edge computing (MEC) capabilities. The heterogeneity of the networks, devices, and services introduces serious vulnerabilities to security attacks, especially distributed denial-of-service (DDoS) attacks, which exploit massive IoT devices to exhaust both network and victim resources. As such, this study proposes MECshield, a localized DDoS prevention framework leveraging MEC power to deploy multiple smart filters at the edge of relevant attack-source/destination networks. The cooperation among the smart filters is supervised by a central controller. The central controller localizes each smart filter by feeding appropriate training parameters into its self-organizing map (SOM) component, based on the attacking behavior. The performance of the MECshield framework is verified using three typical IoT traffic scenarios. The numerical results reveal that MECshield outperforms existing solutions.
Ion radicals. 44. Reactions with 10-phenylphenoxazine cation radical perchlorate (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIon radicals. 44. Reactions with 10-phenylphenoxazine cation radical perchlorateHenry J. Shine and Shi-Ming WuCite this: J. Org. Chem. 1979, 44, 19, 3310–3316Publication Date (Print):September 1, 1979Publication History Published online1 May 2002Published inissue 1 September 1979https://doi.org/10.1021/jo01333a007RIGHTS & PERMISSIONSArticle Views279Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (979 KB) Get e-Alerts Get e-Alerts
The preparation of standard gas mixtures. A review (1981)

The first page of this article is displayed as the abstract.
Las Etapas de la investigación configuracional en las ciencias de la educación (2017)

En este articulo de reflexion derivada de la investigacion doctoral, insistimos en la naturaleza compleja de los objetos de estudio del campo de la educacion, debido a su caracter multidimensional, pluriconfigurado, holistico, procesal y sistemico, porque presentan configuraciones teoricas de las modalidades mas complejas de organizacion de la conciencia y la praxis individual y social. Precisamente, el fundamento de la investigacion configuracional esta dado en todas estas manifestaciones de la complejidad socio-humana. Se hace una distincion entre la investigacion configuracional y la investigacion cualitativa u holistica. Se describe la logica configuracional del conocimiento cientifico y se presentan las etapas de la investigacion configuracional, que en este tipo especifico de investigacion son consideradas eslabones.
A New Route to 2,5-Diamino-4,6-dichloropyrimidine, A Key Precursor of 9-Substituted Guanines (1990)

An improved synthesis of 2,5-diamino-4,6-dihydroxypyrimidine (7) is reported. The direct chlorination of 7 provides the shortest (2 step) synthesis of 2,5-diamino-4,6-dichloropyrimidine (5) reported to date. The procedure described here affords an easy approach to 5, a key intermediate to various 9-substituted guanines.
3D Imaging of Hopping Molecules (2017)

Theoretical predictions have suggested that molecular motion at interfaces-which influences processes including heterogeneous catalysis, (bio)chemical sensing, lubrication and adhesion, and nanomaterial self-assembly-may be dominated by hypothetical "hops" through the adjacent liquid phase, where a diffusing molecule readsorbs after a given hop according to a probabilistic "sticking coefficient." Here, we use three-dimensional (3D) single-molecule tracking to explicitly visualize this process for human serum albumin at solid-liquid interfaces that exert varying electrostatic interactions on the biomacromolecule. Following desorption from the interface, a molecule experiences multiple unproductive surface encounters before readsorption. An average of approximately seven surface collisions is required for the repulsive surfaces, decreasing to approximately two and a half for surfaces that are more attractive. The hops themselves are also influenced by long-range interactions, with increased electrostatic repulsion causing hops of longer duration and distance. These findings explicitly demonstrate that interfacial diffusion is dominated by biased 3D Brownian motion involving bulk-surface coupling and that it can be controlled by influencing short-and long-range adsorbate-surface interactions.
Screening fungi for synthesis of keratinolytic enzymes (1999)

Journal Article Screening fungi for synthesis of keratinolytic enzymes Get access J. Friedrich, J. Friedrich National Institute of Chemistry, Ljubljana, Slovenia and Dr J. Friedrich, National Institute of Chemistry, Hajdrihova 19, SI‐1001 Ljubljana, Slovenia. Search for other works by this author on: Oxford Academic Google Scholar H. Gradišar, H. Gradišar National Institute of Chemistry, Ljubljana, Slovenia and Search for other works by this author on: Oxford Academic Google Scholar D. Mandin, D. Mandin Faculty of Medicine & Pharmacy, University of Franche‐Comté, Besançon, France Search for other works by this author on: Oxford Academic Google Scholar J. P. Chaumont J. P. Chaumont Faculty of Medicine & Pharmacy, University of Franche‐Comté, Besançon, France Search for other works by this author on: Oxford Academic Google Scholar Letters in Applied Microbiology, Volume 28, Issue 2, 1 February 1999, Pages 127–130, https://doi.org/10.1046/j.1365-2672.1999.00485.x Published: 01 February 1999 Article history Received: 19 October 1998 Accepted: 21 October 1998 Published: 01 February 1999
Performance analysis of the anchor radio system handover method for Personal Access Communications System (2002)

This paper presents an analysis of the anchor radio system (RS) handover method for the Personal Access Communications System (PACS). This handover method provides a simple yet effective solution without adding new requirements to the existing network infrastructures. Based on this technique, inter-RS and inter-switch handovers can be achieved using a new RS-to-RS interface called inter-RS interface (IRI). This paper first describes the use of the IRI protocol among PACS based RSs. Then it proposes an analytical model for the Anchor RS handover method to determine the expected handover delay under given mobility, call duration and signaling delay parameters.
Higher-Order-Mode Circularly Polarized Two-Layer Rectangular Dielectric Resonator Antenna (2018)

A two-layer higher-order-mode circularly polarized (CP) rectangular dielectric resonator antenna (DRA) is proposed at a frequency range of 10-13 GHz using a single feed. The configuration incorporates the DRA and a dielectric coat layer with respective dielectric constants of 10 and 3.5. Utilizing the outer layer offers a number of advantages such as a wider impedance and the CP bandwidths of ~21% and 9.5%, respectively, as well as a high gain of ~11 dBic. A close agreement has been achieved between the experimental and simulated results.
Serum transferrin receptor is a truncated form of tissue receptor. (1990)

Recent studies have provided immunological evidence for the existence of transferrin receptor in human serum and have revealed that its concentration is a sensitive measure of erythropoiesis and iron deficiency. The present study was undertaken to establish the molecular identity of this immunoreactive component. Purification from human serum was accomplished by immunoaffinity chromatography using, as the ligand, monoclonal antitransferrin receptor antibody. The receptor preparation contained two major components with Mr of 75,000 and 85,000, which were identified as transferrin and transferrin receptor, respectively. The physicochemical and immunochemical properties of the 85,000 serum receptor were compared with those established for intact placental transferrin receptor. The serum receptor exhibited an apparent Mr = 85,000 on sodium dodecyl sulfate-polyacrylamide gel electrophoresis under non-reducing conditions, as compared with 190,000 for placental transferrin receptor. Upon reduction, the Mr of serum receptor was unaltered, whereas, the 190,000 placental receptor dimer decreased to the expected monomer value of 95,000. Amino-terminal amino acid sequence analysis revealed that residues 1-19 of serum receptor were identical to residues 101-119 of intact receptor. These findings provide physicochemical evidence for the existence of transferrin receptor in human serum, establish its molecular identity as a truncated form lacking the cytoplasmic and transmembrane domains (residues 1-100) of intact receptor, and demonstrate that it exists as a transferrin-receptor complex in serum.
Diagnosing and Mapping Pulmonary Emphysema on X-Ray Projection Images: Incremental Value of Grating-Based X-Ray Dark-Field Imaging (2013)

In a murine model, the complementary information provided by X-ray transmission and dark-field images adds incremental diagnostic value in detecting pulmonary emphysema and visualizing its regional distribution as compared to conventional X-ray projections.
Biofilms, texturas y composición isotópica de travertinos actuales y fósiles, Alhama de Almería-Alicún (Provincia de Almería) (2012)

El estudio de travertinos actuales en Alicun (Almeria), con facies tobaceas asociadas, ha permitido observar la relacion de facies laminares travertinicas (costras) con biofilms. Mediante optica y electronica de barrido sobre muestras fijadas con glutaraldehido y tetroxido de osmio,se han observado cianobacterias (principalmente filamentosas), bacterias y diatomeas formando dichos biofilms. La costra se compone de calcita de bajo contenido en Mg y dolomita, yeso y barita como minerales accesorios. Se ha comparado la composicion isotopica de la calcita VPDB y O18 VPDB) de los materiales actuales: tobas de briofitas y los citados travertinos,con travertinos proximos explotados como roca ornamental,con texturas cristalinas fibrorradiadas similares. Estos ultimos travertinos estan relacionados con manifestaciones hidrotermales de Alhama de Almeria y estan asociados con facies tobaceas. Tambien se han comparado con facies tobaceas, de la misma zona,relacionadas con procesos fluviales mas modernos. Los travertinos de la fuente actual muestran un C13 VPDB ligeramente inferior VPDB: de - 2,13 a -2,04) a las facies equivalentes fosiles: (δC13 VPDB : -1,40 a -1,05). Estos valores ponen de manifiesto la influencia biogenica en ambos materiales. El δO18 VPDB de los travertinos de la fuente, de -10,9 a -9,95 es ligeramente inferior al de los travertinos antiguos (-7,84 a -7,54).
Photoinduced Intramolecular Proton Transfer of Phenol-Containing Ligands and Their Zinc Complexes (2006)

N,N'-Bis(salicylidene)hydrazine (L(I)), a bis-2-hydroxybenzene-type ligand H2L, its tert-butyl derivative (L(II)), and the corresponding Zn2+ complexes of the type Zn2(LH)2L (Zn-I and Zn-II) were synthesized. The molecular structure of Zn-II was determined by X-ray crystallography at -170 degrees C. The photoreactions of the four compounds in solution were studied by time-resolved UV-vis spectroscopy using nanosecond laser pulses. A weak but strongly Stokes shifted fluorescence signal of the ligands L(I) or L(II) is suggested to be due to excited-state intramolecular proton transfer (ESIPT) from the phenolic hydroxy group to the nitrogen of the methine bond in analogy to the fast enol --> keto tautomerization of other 2-hydroxybenzenes. A transient with the maximum at 480 nm, bleaching at 370 nm, and a lifetime of 0.01-0.3 ms is attributed to the trans-keto tautomer, formed via internal conversion. The decay occurs via trans --> cis isomerization and proton back-transfer to the enol form. Quenching by water indicates a proton-catalyzed reaction. To account for similar fluorescence and transient properties in the cases of the Zn2+ complexes, a photoinduced tautomerism at one of the two free phenolic hydroxy groups is proposed. The rapid ESIPT followed by a relatively slow relaxation process is reversible.
Protein Structure Prediction in Structure Based Drug Design (2004)

The human genome and other genome sequencing projects have generated huge amounts of protein sequence information. Recently, a structural genomics project that aims to determine at least one representative three-dimensional structure from every protein family experimentally has been started. Homology modeling will play an essential role in structure based drug design such as in silico screening; because based on these representative structures the three-dimensional structures of the remaining proteins encoded in the various genomes can be predicted by homology modeling. The results of the last Critical Assessment of Techniques for Protein Structure Prediction (CASP5) demonstrated that the quality of homology modeling prediction has improved; reaching a level of reliability that biologists can now confidently use homology modeling. With improvements in modeling software and the growing number of known protein structures, homology modeling is becoming a more and more powerful and reliable tool. The present paper discusses the features and roles of homology modeling in structure based drug design, and describes the CHIMERA and FAMS modeling systems as examples. For a sample application, homology modeling of non-structural proteins of the severe acute respiratory syndrome (SARS) coronavirus is discussed. Many biological functions involve formation of protein-protein complexes; in which the protein molecules behave dynamically in the course of binding. Therefore, an understanding of protein-protein interaction will be very important for structure based drug design. To this end, normal mode analysis is useful. The present paper discusses the prediction of protein-protein interaction using normal mode analysis and examples of applications are given.