gebhart/patrepeval huggingface dataset:
EGFR/Met association regulates EGFR TKI resistance in breast cancer (2010)

Breast cancers show a lack of response to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), despite 30% of tumors expressing EGFR. The mechanism of this resistance is unknown; however, we have recently shown that Met kinase activity compensates for loss of EGFR kinase activity in cell culture models. Met has been implicated in the pathogenesis of breast tumors and therefore may cooperate with EGFR for tumor growth. Here we have found that EGFR phosphorylation and cell proliferation is in part regulated by Met expression. In addition, we found that Met constitutive phosphorylation occurred independent of the Met ligand hepatocyte growth factor (HGF). Ligand-independent Met phosphorylation is mediated by Met amplification, mutation, or overexpression and by Met interaction with other cell surface molecules. In SUM229 breast cancer cells, we found that Met was not amplified or mutated, however it was overexpressed. Met overexpression did not directly correlate with ligand-independent Met phosphorylation as the SUM229 cell line was the only Met expressing breast cancer line with constitutive Met phosphorylation. Interestingly, Met expression did correlate with EGFR expression and we identified an EGFR/Met complex via co-immunoprecipitation. However, we only observed Met constitutive phosphorylation when c-Src also was part of this complex. Ligand-independent phosphorylation of Met was decreased by down regulating EGFR expression or by inhibiting c-Src kinase activity. Lastly, inhibiting EGFR and Met kinase activities resulted in a synergistic decrease in cell proliferation, supporting the idea that EGFR and Met functionally, as well as physically interact in breast cancer cells to regulate response to EGFR inhibitors.
Evaluation of gradient-index rod lenses by imaging (1980)

This paper presents a new technique for evaluating a gradient-index rod lens that has a radial gradient index of refraction and can be used as an imaging or light-focusing device. The index profile is analytically related to imaging in terms of simple expressions for the aberrations. It is shown that the index profile can be easily checked by observing the distortion or field curvature of the image. A plastic gradient-index rod lens is evaluated by means of a proposed aberration-testing method, and the index profile is estimated.
The formation of propylene fumarate oligomers for use in bioerodible bone cement composites (1990)

Abstract Poly(propylene fumarate) (PPF) oligomers were synthesized by step polymerization using bis(2‐hydroxypropyl fumarate) or propylene bis(hydrogen maleate) as starting materials. Oligomers possessing identical degrees of polymerization (DP), but varying in their end group character (either hydroxyl or carboxyl) were first prepared and characterized, then used as part of a bone cement preparation consisting of oligomer, tricalcium phosphate, calcium carbonate, and methyl methacrylate. Compressive strength of the resulting composite appeared to be dependent on both the degree of polymerization of the PPF, and the nature of the oligomers' end groups.
A certifying compiler for Java (2000)

This paper presents the initial results of a project to determine if the techniques of proof-carrying code and certifying compilers can be applied to programming languages of realistic size and complexity. The experiment shows that: (1) it is possible to implement a certifying native-code compiler for a large subset of the Java programming language; (2) the compiler is freely able to apply many standard local and global optimizations; and (3) the PCC binaries it produces are of reasonable size and can be rapidly checked for type safety by a small proof-checker. This paper also presents further evidence that PCC provides several advantages for compiler development. In particular, generating proofs of the target code helps to identify compiler bugs, many of which would have been difficult to discover by testing.
Graphitized lignin-based activated carbon fibers and their application in supercapacitors (2022)

Abstract As an abundant bioresource of carbon, lignin has the potential to form carbon fibers (CFs), which can then be used as electrode materials in supercapacitors. However, most studies have only focused on the morphology of CFs, such as the specific surface area and pore-size distribution, while ignoring the influence of the carbon structure in CFs. In this study, Ni(acac) 2 was used as a graphitization catalyst in CFs preparation and to further modify the morphology of the fibers. Meanwhile, the addition of Ni(acac) 2 remarkably shortened the thermostabilization period from 76 h to 2.25 h, which significantly reduced the energy consumption. The resulting lignin-based activated carbon fibers (LACFs) with graphitized structures presented a controllable pore-size distribution and large surface areas up to 582.7 m 2 g − 1 . These LACFs were then used as electrode materials in supercapacitors, and the assembled devices displayed high energy and power densities of up to 22.1 Wh kg − 1 and 239 kW kg − 1 , respectively, using organic electrolytes.
Communications: Tin cluster anions (Snn−, n=18, 20, 23, and 25) comprise dimers of stable subunits (2010)

The gas phase structures of tin cluster anions Sn(n)(-) have been studied by a combination of trapped ion electron diffraction and density functional theory calculations. In the size range of n=18-25 these clusters comprise dimers of stable subunits. In particular Sn(18)(-) and Sn(20)(-) are homodimers of Sn(9) and Sn(10) subunits, respectively. In Sn(23)(-) two Sn(10) units are linked by three additional bridging atoms and Sn(25)(-) is a heterodimer of Sn(10) and Sn(15) subunits. This rather unexpected growth mode is rationalized by the extraordinary stability of the building blocks Sn(9), Sn(10), and Sn(15).
Noise Processing by Wavelets Convolution Technique (2000)

We have studied the visualization of the current distributions from the locally measured magnetic fields. In order to visualize the current distributions, it is intrinsically reduced into solving an ill-posed inverse problem. In most cases, the solutions of the ill-posed inverse problems tend to increase the noise, and the threshold operation is used for the noise reduction. Though this operation is strong noise reduction strategy, it needs a lot of trial and error and experiences for deciding the threshold value.In the present paper, we propose one of the methodologies of the noise processing. At first, we apply the generalized vector sampled pattern matching (GVSPM in short) method to visualizing the quasi-3D current vector distributions. Second, in order to extract the major current vectors, we apply the 3D vector wavelet transforms employing the several wavelet base function to the noisy current vectors. Consequently, in order to extract common current vectors among them, each of the current vectors was convoluted. Thus, we have succeeded in visualizing the quasi-3D current vector distributions without any threshold operation.
Peritoneal Resorption Capacity for Lipopolysaccharide and Interleukin-6 in Acute Zymosan-Induced Chemical Peritonitis (2011)

There was a reduction of resorption capacity of inflamed peritoneum for inflammatory mediators in acute chemical peritonitis.
Biological and immunological characterization of inhibin forms in human plasma. (1996)

A number of immunoassay methods have been developed recently to detect specifically the bioactive alpha-beta A subunit inhibin dimer (inhibin A) in human plasma. However, the specificity of these assays in terms of their ability to detect the range of inhibin forms found in plasma and their relationship to bioactivity have not been investigated. Inhibin was fractionated from human follicular fluid (hFF) and serum/plasma from women stimulated with gonadotropins (IVF serum), and from postmenopausal and male plasma, using a combined immunoaffinity/preparative SDS-PAGE procedure. The molecular weight profile of inhibin was established by inhibin in vitro bioassay, three alpha-beta A subunit specific immunoassays, and three alpha subunit-directed immunoassays that detect the alpha subunit as well as inhibin A and B forms. In hFF inhibin forms of 33, 36, 55 and 66K were detected by in vitro bioassay and by most immunoassays except for 33 k inhibin, which was nondetectable by one alpha-beta A ELISA. The alpha subunit-directed assays also detected activity in the 29-31K region, in some assays in considerably high levels. In IVF serum in vitro bioactivity and immunoactivities were detected between 27 and 100K with the alpha-beta A assays failing to detect all bioactive forms. Alpha subunit-directed assays gave similar immunoactive profiles. Neither in vitro bioassay nor alpha-beta A assays detected activity in post-menopausal plasma or male plasma, while alpha subunit-directed assays showed peaks predominantly at 36 k, although at low levels. It is concluded that dimeric inhibin A specific assays detected bioactive inhibin forms in hFF and to a lesser extent in IVF serum. Alpha subunit-directed assays correlated poorly with in vitro bioassay in hFF because of the high alpha subunit levels in this sample. The higher correlation between these assays in IVF serum suggested that there was little free alpha subunit. The 36K form in male plasma may be free alpha subunit or inhibin B.
Two simulators for photonic computer-aided design (1998)

The computer-aided design of photonic systems offers many advantages for systems design, optimization, and planning. We present a comparison of two simulation packages for photonic-device, circuit, and system design. Both were developed by the Australian Photonics Cooperative Research Centre: the optoelectronic, photonic, and advanced laser simulator performs step-by-step simulations on complex photonic devices, circuits, and systems, allowing for backward waves and compound resonators; the gigabit optical link designer uses block processing of periodic waveforms to give an efficient estimation of eye diagrams and bit-error rates of time-division-multiplexed and wavelength-division-multiplexed systems. The gigabit optical link designer and the optoelectronic, photonic advanced laser simulator are compared, and examples of typical applications are given.
Molecular characterization, sequence analysis and tissue expression of a porcine gene –MOSPD2 (2016)

The full-length cDNA sequence of a porcine gene, MOSPD2, was amplified using the rapid amplification of cDNA ends method based on a pig expressed sequence tag sequence which was highly homologous to the coding sequence of the human MOSPD2 gene. Sequence prediction analysis revealed that the open reading frame of this gene encodes a protein of 491 amino acids that has high homology with the motile sperm domain-containing protein 2 (MOSPD2) of five species: horse (89%), human (90%), chimpanzee (89%), rhesus monkey (89%) and mouse (85%); thus, it could be defined as a porcine MOSPD2 gene. This novel porcine gene was assigned GeneID: 100153601. This gene is structured in 15 exons and 14 introns as revealed by computer-assisted analysis. The phylogenetic analysis revealed that the porcine MOSPD2 gene has a closer genetic relationship with the MOSPD2 gene of horse. Tissue expression analysis indicated that the porcine MOSPD2 gene is generally and differentially expressed in the spleen, muscle, skin, kidney, lung, liver, fat and heart. Our experiment is the first to establish the primary foundation for further research on the porcine MOSPD2 gene.
Space Radiation Organ Doses for Astronauts on Past and Future Missions (2007)

We review methods and data used for determining astronaut organ dose equivalents on past space missions including Apollo, Skylab, Space Shuttle, NASA-Mir, and International Space Station (ISS). Expectations for future lunar missions are also described. Physical measurements of space radiation include the absorbed dose, dose equivalent, and linear energy transfer (LET) spectra, or a related quantity, the lineal energy (y) spectra that is measured by a tissue equivalent proportional counter (TEPC). These data are used in conjunction with space radiation transport models to project organ specific doses used in cancer and other risk projection models. Biodosimetry data from Mir, STS, and ISS missions provide an alternative estimate of organ dose equivalents based on chromosome aberrations. The physical environments inside spacecraft are currently well understood with errors in organ dose projections estimated as less than plus or minus 15%, however understanding the biological risks from space radiation remains a difficult problem because of the many radiation types including protons, heavy ions, and secondary neutrons for which there are no human data to estimate risks. The accuracy of projections of organ dose equivalents described here must be supplemented with research on the health risks of space exposure to properly assess crew safety for exploration missions.
Frankfurters with Lean Finely Textured Tissue as Affected by Ingredients (1996)

ABSTRACT Increasing salt concentration from 1.5 to 2.5% increased the emulsion stability of frankfurters made with lean finely textured tissue (LFTT). Sodium tripolyphosphate (STPP) at 0.25% improved stability and texture as well as processing and consumer cooking yields. Kappa (K)‐carra‐geenan (0.5%) reduced cooking losses and increased firmness. Isolated soy protein (ISP) at 2% also improved product stability and firmness but lowered sensory scores. The effect of ISP on sensory scores was greater for those frankfurters produced from lean finely textured beef than for those with lean finely textured pork. Increasing NaCl concentration or including STPP and K‐carrageenan may improve comminuted meat products which contain 50% LFTT substituted for lean meat.
Simultaneous Determination of Hydroquinone and Catechol using Carbon Glass Electrode Modified with Graphene Quantum Dots (2018)

In this study, an electrochemical sensor for the simultaneous detection of hydroquinone (HQ) and catechol (CC) was fabricated on glassy carbon electrode (GCE) modified with graphene quantum dots (GQDs). The prepared GQDs were characterized by transmission electron microscope and fourier transform infrared spectroscopy. The GQDs/GCE, which prepared by electrodeposition method, and characterized by electrochemical impedance spectra, exhibited excellent electrochemical catalysis and conductive properties for HQ and CC. Owing to the high electroactive surface area, good electrocatalytic activity and low charge transfer resistance of GQDs, HQ and CC can be easily measured simultaneously for the large separation of oxidation peak potentials (113 mV) and do not interfere with each other. Under the optimal experimental condition, the oxidation peak currents were linear to HQ/CC in the range from 0.5 μM to 100 μM with the same low detection limits of 0.08 μM (S/N=3). Simultaneous determination of HQ and CC with such electrode was conducted in river water samples with reliable recovery between 97.90% and 103.9%.
Product Architecture and Modularization Process for Brownfield Development (2014)

This paper describes the investigation of the industrial need in standardized products, the role of product architecture in modularization and a suitable product development process implementation. A comprehensive approach of implementing standardized product architecture for an industrial “brownfield development” and a methodology for redesigning existing modularization concepts are the main contents, as well as a detailed overview and assessment of existing modularization approaches in engineering science and industrial practice.
A 195Gb/s 1.2W 3D-stacked inductive inter-chip wireless superconnect with transmit power control scheme (2005)

An inductively coupled wireless interface achieves aggregated data rate of 195Gbit/s among 4 stacked chips in a package by arranging 195 transceivers in 50/spl mu/m pitch with power dissipation of 1.2W. The transmit power is controlled in accordance to the communication distance to reduce both the power dissipation and the crosstalk of the system.
Splitting of absorptance peaks in absorbing multilayer backed by a periodically corrugated metallic reflector (2016)

The excitation of modes of an open-face slab waveguide by light incident on a thin-film photovoltaic solar cell with a periodically corrugated metal backreflector is indicated by peaks in the absorptance spectrum. An absorptance peak due to the excitation of a waveguide mode (WGM) can split as the corrugation depth increases. The splitting can be explained in terms of the wavenumbers of the WGMs of two open-face slab waveguides with different thicknesses of the semiconductor layer. The splitting of short-wavelength peaks occurs for smaller corrugation depths than the splitting of long-wavelength peaks, suggesting that the corrugations need not be very deep for optimal absorption of solar photons.
An MR compatible PET scanner for imaging small animals (2004)

Combined PET–CT scanners are becoming standard for clinical PET imaging. The development of a combined PET–MR scanner poses greater technological challenges. A prototype small animal MR compatible PET scanner has previously been designed, constructed and evaluated in collaboration with UCLA School of Medicine. Final tests have now been carried out to validate the design of a new system that addresses the limitations of the prototype. The new scanner will consist of one ring of 416 LSO crystals (2×3×5 mm) arranged in 4 layers with an inner diameter of 7.5 cm and will be used for molecular imaging studies with mice and small rats. Each crystal is coupled to 1 of 8 multi-channel photomultiplier tubes, situated away from the MR scanner, via 3 m long optical fibres. Experiments have been performed to optimize all aspects of the system. Results of the validation studies and the configuration of the new system will be described. The system is now under construction and we predict it will have a uniform spatial resolution of <2 mm over a 6 cm FOV with a sensitivity and maximum count rate more than 10 times that of the prototype.
Transmission infrared spectroscopy of whole blood – complications for quantitative analysis from leucocyte adhesion during continuous monitoring (2010)

Infrared spectroscopy has been applied to analyse glucose and cellular components in whole blood with the aim of developing an online clinical diagnostic and monitoring modality. Leucocyte adsorption onto the CaF(2) windows was observed over a period of several hours under continuous blood flow using a transmission cell of 30 mum path length. This build-up of cellular material on the windows is responsible for diminishing the sample path length under the flow conditions chosen. The adsorption dynamics have been characterised and their impact on glucose monitoring is reported. For short-term monitoring (<2 hours) a standard error of prediction of 11 mg/dL with human citrated blood samples from three different subjects was achieved. Furthermore, the leucocyte build-up was also reported for porcine EDTA blood monitoring. Consequences and testing opportunities with regard to the first stages in the immune cell reaction to the exposure of body-foreign materials to anticoagulated whole blood are discussed.
A novel NFkB1 mutation linking pyoderma gangrenosum and common variable immunodeficiency (2021)

Pyoderma gangrenosum (PG) is a sterile neutrophilic dermatosis manifesting as painful inflammatory plaques and ulcers, frequently associated with inflammatory bowel disease, rheumatoid arthritis, myelodysplastic syndrome, and acute myeloid leukemia.1 We present a case of a young woman with a novel mutation in NFkB1 who experienced common variable immunodeficiency (CVID) and severe recurrent PG episodes.
The high field, high frequency permeability of narrow, thin-film magnetic stripes (1991)

The authors report measurements of the magnetic response of arrays of narrow Permalloy stripes using a high field permeameter. The permeameter operates in a swept frequency mode from 300 KHz to 30 MHz with a field amplitude of up to 5 Oe. Using this device, two modes of flux conduction, rotation and wall motion, can be observed in narrow Permalloy stripes. The low field-amplitude permeability of narrow unlaminated Permalloy stripes is frequency independent except for eddy current losses as expected for magnetization rotation. At higher fields the magnetic response increases at frequencies below 10 MHz with increasing drive amplitude as domain wall motion becomes significant. Results are consistent with the expected domain wall mobility (around 2*10/sup 3/ cm/(s-Oe) for 2- mu m-thick films). Because of the high density of wall in microscopic structures, wall motion is the dominant flux conduction mechanism below 30 MHz at high drive fields.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
GaN-based light-emitting diodes on graphene-coated flexible substrates (2014)

We demonstrate GaN-based thin light-emitting diodes (LEDs) on flexible polymer and paper substrates covered with chemical vapor deposited graphene as a transparent-conductive layer. Thin LEDs were fabricated by lifting the sapphire substrate off by Excimer laser heating, followed by transfer of the LEDs to the flexible substrates. These substrates were coated with tri-layer graphene by a wet transfer method. Optical and electrical properties of thin laser lift-offed LEDs on the flexible substrates were characterized under both relaxed and strained conditions. The graphene on paper substrates remained conducting when the graphene/paper structure was folded. The high transmittance, low sheet resistance and high failure strain of the graphene make it an ideal candidate as the transparent and conductive layer in flexible optoelectronics.
Experimental Studies on a Scaled Model of a Tension Based Tension Leg Platform under Combined Mooring and Tether Conditions (2014)

Tension Based Tension Leg Platform (TBTLP) is an innovative concept wherein a Tension Leg Platform (TLP) designed for a certain depth can be extended to operate in deeper waters by mounting the surface structure (TLP) on a buoyant closed box structure, Tension Base. The motion control of Tension Base is very important for satisfactory performance of the mounted TLP. In this paper, the concepts are briefly introduced and experiments conducted on a 1:150 scaled model of the TBTLP in 3 m water depth with three different combinations of tether and mooring stiffnesses are presented. Experiments were also conducted on the same TLP (without Tension Base) in two different water depths (3 m and 1 m). Results are presented in terms of Response Amplitude Operators (RAOs) in the surge, heave and pitch degrees of freedom of TBTLP and are compared with RAOs of TLPs in 3 m and 1 m to highlight the efficacy of the new concept.
A self-servowrite clocking process (2001)

A high-speed process for servowriting hard-disk assemblies (HDAs) without an external clock head has been developed. This robust process achieves servo-pattern alignment accuracy comparable to or better than that achieved with conventional clock-head based servowriters at a substantially reduced capital and process cost.
Gold nanoprisms as transducers for the development of plasmonic photothermal biosensors (2019)

Resumen del póster presentado a la 2nd Spanish Conference on Biomedical Applications of Nanomaterials (SBAN), celebrada en Madrid del 6 al 7 de junio de 2019.