gebhart/patrepeval huggingface dataset:
Synthesis, Characterization, and Biological Activity of Ferrocenyl Analogues of the Anthelmintic Drug Monepantel (2016)

There is major demand for the development of structurally new anti-infectives using innovative approaches to circumvent multidrug resistance in parasites. Herein, we describe the synthesis and characterization of ferrocenyl precursors and derivatives (2–8) of an anthelmintic drug, monepantel. All compounds were isolated as their racemates and characterized by 1H, 13C, and 19F NMR spectroscopy, mass spectrometry, and IR spectroscopy. The purity of individual compounds was confirmed by elemental microanalysis. The molecular structures of three of the organometallic compounds (5–7) were also established by X-ray crystallography. The biological activities of these compounds were then evaluated in vitro on various important eukaryotic parasites, including H. contortus, T. colubriformis, and D. immitis. The potencies against D. immitis (canine heartworm) of two compounds, a ferrocene-containing precursor (4) and the final ferrocene-based monepantel derivative (8), were shown to be moderate (EC50 = 3.70 μg/mL for 4 and 5.60 μg/mL for 8) and were comparable with those of the controls AAD85 (EC50 = 2.20 μg/mL) and a commercial drug, ivermectin (EC50 = 1.00–3.00 μg/mL). The assessment of the cytotoxicity using cancerous HeLa and noncancerous MRC-5 cell lines revealed that these compounds have moderate to low toxicities in mammalian cells, thereby showing selective activity on parasites.
Dissection of the Antibody Response against Herpes Simplex Virus Glycoproteins in Naturally Infected Humans (2014)

Antibodies targeting functional epitopes on HSV entry glycoproteins mediate HSV neutralization. Virus-neutralizing epitopes have been defined and characterized using murine monoclonal antibodies. However, it is largely unknown whether these same epitopes are targeted by the humoral response to HSV infection in humans. We have shown that during natural infection, virus-neutralizing antibodies are principally directed against gD, gB, and, to a lesser extent, gC. While several key HSV-neutralizing epitopes within gD and gB are commonly targeted by human serum IgG, others fail to induce consistent responses. These data are particularly relevant to the design of future HSV vaccines.
Low efficiency of functional translation of ouabain-resistant α2-Na+,K+-ATPase mRNA in C7-MDCK epithelial cells (2012)

Na(+),K(+)-ATPase is a heterodimer consisting of catalytic α1-α4 and regulatory β1-β3 subunits. Recently, we reported that transfection with ouabain-resistant α1R-Na(+),K(+)-ATPase rescues renal epithelial C7-MDCK cells exclusively expressing the ouabain-sensitive α1S-isoform from the cytotoxic action of ouabain. To explore the role of α2 subunit in ion transport and cytotoxic action of ouabain, we compared the effect of ouabain on K(+) ((86)Rb) influx and the survival of ouabain-treated C7-MDCK cells stably transfected with α1R- and α2R-Na(+),K(+)-ATPase. α2R mRNA in transfected cells was ∼8-fold more abundant than α1R mRNA, whereas immunoreactive α2R protein content was 5-fold lower than endogenous α1S protein. A concentration of 10 µmol/L ouabain led to complete inhibition of (86)Rb influx both in mock- and α2R-transfected cells, whereas maximal inhibition of (86)Rb influx in α1R-transfectd cells was observed at 1000 µmol/L ouabain. In contrast to the massive death of mock- and α2R-transfected cells exposed to 3 µmol/L ouabain , α1R-cells survived after 24 h incubation with 1000 µmol/L ouabain. Thus, our results show that unlike α1R, the presence of α2R-Na(+),K(+)-ATPase subunit mRNA and immunoreactive protein does not contribute to Na(+)/K(+) pump activity, and does not rescue C7-MDCK cells from the cytotoxic action of ouabain. Our results also suggest that the lack of impact of transfected α2-Na(+),K(+)-ATPase on Na(+)/K(+) pump activity and cell survival can be attributed to the low efficiency of its translation and (or) delivery to the plasma membrane of renal epithelial cells.
The Surgical Isolator (1974)

A plastic film isolator has been developed which is intermediate between a half-suit and an arm isolator. Used for orthopaedic surgery in an aseptic environment few operating difficulties have been found, and an extended trial of its use should be carried out to assess its effect on the incidence of postoperative wound infection.
Accuracy of Helicobacter pylori Diagnostic Tests in Patients with Bleeding Peptic Ulcer: A Systematic Review and Meta-analysis (2006)

Biopsy-based methods, such as rapid urease test, histology, and culture, have a low sensitivity, but a high specificity, in patients with UGIB. The accuracy of 13C-urea breath test remains very high in these patients. Stool antigen test is less accurate in UGIB. Although serology seems not to be influenced by UGIB, it cannot be recommended as the first diagnostic test for H. pylori infection in this setting.
Decision-Making Technology for Autonomous Vehicles Learning-Based Methods, Applications and Future Outlook (2021)

Autonomous vehicles have a great potential in the application of both civil and military fields, and have become the focus of research with the rapid development of science and economy. This article proposes a brief review on learning-based decision-making technology for autonomous vehicles since it is significant for safer and efficient performance of autonomous vehicles. Firstly, the basic outline of decision-making technology is provided. Secondly, related works about learning-based decision-making methods for autonomous vehicles are mainly reviewed with the comparison to classical decision-making methods. In addition, applications of decision-making methods in existing autonomous vehicles are summarized. Finally, promising research topics in the future study of decision-making technology for autonomous vehicles are prospected.
New and effective reagents for 1,4 reduction of .alpha.,.beta.-unsaturated ketones, LiAlH4-CuI and Its reactive species H2AlI (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew and effective reagents for 1,4 reduction of .alpha.,.beta.-unsaturated ketones, LiAlH4-CuI and Its reactive species H2AlIE. C. Ashby, J. J. Lin, and R. KovarCite this: J. Org. Chem. 1976, 41, 11, 1939–1943Publication Date (Print):May 1, 1976Publication History Published online1 May 2002Published inissue 1 May 1976https://pubs.acs.org/doi/10.1021/jo00873a011https://doi.org/10.1021/jo00873a011research-articleACS PublicationsRequest reuse permissionsArticle Views1950Altmetric-Citations53LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Raman analysis and field emission study of ion beam etched diamond films (1999)

Discontinuous diamond films were deposited on silicon using a microwave plasma chemical vapor deposition system. The diamond deposits were sharpened by argon ion beam etching. Raman spectroscopy was carried out to study the structural change of the diamond after ion beam bombardment. It was found that amorphous sp2 carbon is produced as diamond is being sputtered by the Ar ion beam. The field emission turn-on field was also drastically lowered after sharpening, which, it is speculated, is caused by field enhancement due to change in geometry and/or structural changes (such as amorphization of crystalline diamond into graphitic or amorphous sp2 carbon) by Ar ion irradiation.
Dental Pain in Cats: A Prospective 6-Month Study (2022)

Dental pathology is among the most ubiquitous diseases in cats of all ages. Dental pain is yet to be fully understood in cats and therefore its presence is often missed. To better understand feline dental disease as a pain trigger during routine examination and whether disease severity correlates to the degree of pain, a 6-month prospective study in a cats' only veterinary hospital in Portugal was conducted. Sixty-four cats that randomly presented for different clinical procedures were evaluated. Dental and periodontal abnormalities (primary dental parameters, PDP), as well as clinical signs related to dental pain (secondary dental parameters, SDP), were assessed. All cats underwent an oral cavity examination, upon which, the Feline Acute Pain Scale from Colorado State University Veterinary Teaching Hospital (CPS), was used in order to assess pain. Six PDP (periodontal disease, gingival index, calculus index, tooth resorption, tooth fracture and missing teeth) and five SDP (mouth discomfort, halitosis, hypersalivation, difficulty in holding food and several attempts at prehension of food), were compared with CPS pain scores. All SDP were significantly associated to higher CPS pain scores (p < 0.05). The number of missing teeth was significantly associated to higher CPS pain scores (p < 0.0001). A trend was observed between higher CPS pain scores and tooth resorption (p = 0.08). This study concluded that cats with dental disease feel pain during clinical examination and the pain increases as the severity of the disease progresses.
Isolation of a Sindbis virus variant by passage on mouse plasmacytoma cells (1975)

A variant of Sindbis virus has been isolated by growing a stock of virus, previously passaged on chicken embryo cells, in mouse plasmacytoma (MOPC 315) cells in suspension culture. An indirect immunofluorescence test and infective center assay showed that only a small fraction of cells could be infected by the stock wild-type virus, but that the population of virus accumulating after a few passages on the mouse cells had host-range properties distinct from the stock virus. The mouse-passaged virus retained its virulence for the original host and back-passaging of this virus on chicken cells did not change its newly acquired properties. Thus, this variant appears to be a genetically distinct form of Sindbis that adsorbs to and grows much better than the stock virus on several types of mouse cells including cultures of mouse macrophages.
Probabilistic overall reconstruction of membrane-associated molecular dynamics from partial observations in rod-shaped bacteria (2019)

International audience
Vertical-coupled high-efficiency tunable III-V- CMOS SOI hybrid external-cavity laser (2013)

We demonstrate a hybrid III-V/SOI laser by vertically coupling a III-V RSOA chip with a SOI-CMOS chip containing a tunable wavelength selective reflector. We report a waveguide-coupled wall-plug-efficiency of 5.5% and output power of 10 mW. A silicon resistor-based microheater was integrated to thermally tune a ring resonator for precise lasing wavelength control. A high tuning efficiency of 2.2 nm/mW over a range of 18 nm was achieved by locally removing the SOI handler substrate. C-band single mode lasing was confirmed with a side mode suppression ratio of 35 dB. This grating coupler based vertical integration approach can be scaled up in two dimensions for efficient multi-wavelength sources in silicon photonics.
Q-Learning-Based Power Allocation for Secure Wireless Communication in UAV-Aided Relay Network (2021)

Unmanned aerial vehicle (UAV)-aided wireless relay networks are at risk of eavesdropping activities due to their open nature. In this paper, we study the security of a UAV-aided selective relaying wireless network in which N UAVs are employed as decode-and-forward (DF) relays linking a ground base station (BS) with L legitimate users on the ground in the presence of a passive eavesdropper ( Eave). Direct links between the ground BS and both the ground users and the eavesdropper are assumed to be blocked. The ground-to-air and air-to-ground channels are assumed to follow Rician fading model with opportunistic scheduling scheme for UAVs and users selection. In order to secure data transmissions against such an interception action, the UAV of the worst UAV-selected user link transmits a jamming artificial noise (AN) signal to degrade Eave ability in decoding the confidential information successfully. The transmission outage probability, intercept probability, and hybrid outage probability are derived and analyzed. Due to the heavy computation burden raised by increasing the number of UAVs and users as well as the difficulty in estimating the instantaneous channel state information (CSI), existing traditional optimization methods are not highly efficient in solving the considered power allocation problem. Therefore, we propose a dynamic power control scheme based on Q-learning algorithm combined with statistical CSI where the hybrid outage probability is minimized. Simulation results show that the proposed algorithm efficiently reduces the hybrid outage probability with a noticeable reduction in the computational time.
Distribution of bacterioplankton in meromictic Lake Saelenvannet, as determined by denaturing gradient gel electrophoresis of PCR-amplified gene fragments coding for 16S rRNA (1997)

The community structure of bacterioplankton in meromictic Lake Saelenvannet was examined by PCR amplification of the V3 region of 16S rRNA from microbial communities recovered from various depths in the water column. Two different primer sets were used, one for amplification of DNA from the domain Bacteria and another specific for DNA from the domain Archaea. Amplified DNA fragments were resolved by denaturing gradient gel electrophoresis (DGGE), and the resulting profiles were reproducible and specific for the communities from different depths. Bacterial diversity estimated from the number and intensity of specific fragments in DGGE profiles decreased with depth. The reverse was true for the Archaea, with the diversity increasing with depth. Hybridization of DGGE profiles with oligonucleotide probes specific for phylogenetic groups of microorganisms showed the presence of both sulfate-reducing bacteria and methanogens throughout the water column, but they appeared to be most abundant below the chemocline. Several dominant fragments in the DGGE profiles were excised and sequenced. Among the dominant populations were representatives related to Chlorobium phaeovibrioides, chloroplasts from eukaryotic algae, and unidentified Archaea.
Quantification of uncertainties in remotely derived optical properties of coastal and oceanic waters (2010)

Optical properties of oceanic and coastal waters are not only important for describing subsurface light field, but also useful indexes of environmental status. To meet the demand of various users, optical data products of global waters are now generated from ocean color satellite sensors (e.g. SeaWiFS, MODIS, MERIS). These products, due to imperfect sensor technology and retrieval algorithms, inherently contain some degrees of uncertainties. Traditionally, an averaged difference (or so-called error) for a dataset is usually provided via comparing retrieved values with in situ measurements. This averaged "error" is good at providing an overall picture between the retrieved and measured properties, but cannot indicate uncertainties for a specific product or a pixel, because that uncertainties in these products are not spatially uniform. Here, using optical properties derived from the Quasi-Analytical Algorithm as an example, we present an approach to quantify pixel-wise uncertainties of remote-sensing derived properties. Further, we quantitatively evaluated the uncertainties of the derived inherent optical properties (IOPs) and water-clarity products with a simulated dataset, and found that the relative uncertainty is generally within 10% for total absorption coefficients of oceanic waters. This presentation shows the theoretical basis to evaluate and understand the impacts of the various components on the analytically derived optical properties, and that a practical means to quantify the uncertainties of inverted properties for each reflectance spectrum is now available. This effort lays the groundwork for generating quality maps of optical properties derived from satellite ocean color images.
ChemInform Abstract: Synthesis of Novel Halopyridinylboronic Acids and Esters. Part 2. 2,4, or 5‐Halopyridin‐3‐yl‐boronic Acids and Esters. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
6.4 A 1-to-3GHz Co-Channel Blocker Resistant, Spatially and Spectrally Passive MIMO Receiver in 65nm CMOS with +6dBm In-Band/In-Notch B1dB (2021)

MIMO techniques exploit multipath signals from all directions. Unfortunately, this means that all the antennas can be jammed by a single co-channel blocker from any direction. Linear filtering techniques, that have an inverse, can be used to provide RF beamforming when combined with a baseband inverse without losing any of the multipath information. An example of such a filter includes the FFT/IFFT combination, shown in Fig. 6.4.1. Prior techniques have attempted to solve the MIMO co-channel blocker problem by providing nulls in individual directions [1]. These techniques provide finite jammer rejection in only one spatial direction. These have been extended to handle multiple spatial blockers [2]-[4]. However, all these techniques use active circuits for spatial filtering, which limits the ability to handle co-channel interference.
Clinical and epidemiological investigations of Acinetobacter genomospecies 3 in a neonatal intensive care unit (1995)

A prospective study of Acinetobacter isolates from a neonatal intensive care unit was performed for 24 months. Fifty-six isolates were obtained from 21 patients, and another eight were obtained from environmental specimens. Infection due to Acinetobacter organisms was established for 16 patients, 6 with septicemia, 9 with pneumonia, and 1 with a wound infection. Further investigations were performed with 38 representative isolates. Twenty-nine isolates were identified as unnamed DNA-DNA hybridization group (genomospecies) 3, three were identified as genomospecies 2 (Acinetobacter baumannii), one was identified as genomospecies 5 (Acinetobacter junii), three were identified as genomospecies 14, and two were unclassified. Eight distinguishable protein profiles, coded I through VIII, were found by cell envelope protein electrophoresis. Profile V, a common profile, was observed for 17 isolates that had been recovered from 11 patients and 1 dust specimen. These isolates, all of which belonged to genomospecies 3, had similar antibiograms and biotypes. This study has revealed that genomospecies 3 can be associated with infection and be spread in hospitals.
Controlling ultrafast photoelectron dynamics in nanostructure-enhanced THz fields (2014)

We present experimental results on a nanostructure streaking scheme employing carrier-envelope-phase-stable THz pulses to control ultrafast photoemission. The tip-enhanced local THz-field allows for field-driven electron dynamics and effective manipulation of trajectories and kinetic energy spectra.
A Straightforward Access to Cyclotriveratrylene Analogues with C1 Symmetry: Toward the Synthesis of Monofunctionalizable Cryptophanes (2017)

A straightforward and practical access to various C 1 ‐symmetric cyclotriveratrylene derivatives from a monohalogenated cyclotriphenolene is described. This unique scaffold can be used as a precursor for the rapid construction of monofunctionalizable cryptophane‐based biosensors for hyperpolarized 129 Xe MRI.
Association of protein-tyrosine kinase with phospholipase C-gamma 1 in bone marrow-derived mouse mast cells. (1992)

Bone marrow-derived mouse mast cells contain phospholipase C-gamma 1 (PLC-gamma 1), which is phosphorylated at tyrosine residues upon cross-linking of cell-bound IgE antibodies with multivalent antigen. It was found that immune complexes formed from digitonin lysates of the mast cells by monoclonal anti-PLC-gamma 1 antibodies contained protein-tyrosine kinase (PTK), which phosphorylated PLC-gamma 1 in vitro. The tyrosine kinase activity coprecipitated with PLC-gamma 1-anti-PLC-gamma 1 complexes markedly increased when the cell lysates were obtained immediately after antigen challenge. The results indicate that PTK is associated with PLC-gamma 1 in the mast cells and that the kinase is activated upon cross-linking of Fc epsilon RI. Neither beta nor gamma subunit of Fc epsilon RI nor src family PTK was coprecipitated with the PLC-gamma 1-anti-PLC-gamma 1 complexes. In situ denaturation/renaturation experiments, which detect autophosphorylated kinases, indicated that the PTK associated with PLC-gamma 1 was a 44-kDa protein.
The Campaign to Eliminate the Midwife (2000)

Katy Dawley is the director of midwifery in the Department of Obstetrics and Gynecology at MCP-Hahnemann University and is a PhD student at the University of Pennsylvania in Philadelphia.
French maritime pine bark extract significantly lowers the requirement for analgesic medication in dysmenorrhea: a multicenter, randomized, double-blind, placebo-controlled study. (2008)

The analgesic-sparing effect of Pycnogenol increases with duration of supplementation and benefits persist even after discontinuation.
Isobaric Vapor–Liquid Equilibrium Data for the Binary Systems of Dimethyl Carbonate with Xylene Isomers at 93.13 kPa (2017)

Isobaric binary vapor–liquid equilibrium (VLE) data for dimethyl carbonate with xylene isomers (p-xylene, m-xylene, o-xylene, and ethylbenzene) were measured at the local atmospheric pressure of 93.13 kPa by using a dynamic recirculation still. The experimental VLE data were tested and found to be thermodynamically consistent by Herington and Van Ness consistency test. The experimental VLE data were correlated using the Wilson, NRTL, and UNIQUAC activity coefficient models and binary interactions parameters were estimated using a suitable objective function. The absolute mean deviation between the experimental and the model predicted values of vapor phase composition and total pressure was well within acceptable limits. No azeotrope was observed in any of the binary pairs and appeared to be easy for separation using conventional distillation method.
The Metabolism of Aromatic Compounds in Higher Plants (1966)

Abstract The hydroxynitrile lyases of etiolated sorghum seedlings and ground almonds have been purified to homogeneity as seen in the analytical ultracentrifuge. The sorghum enzyme preferentially catalyzed the dissociation of p-hydroxymandelonitrile, whereas the almond enzyme exhibited its maximum rate on mandelonitrile; p-hydroxybenzaldehyde and benzaldehyde, respectively, together with HCN, were the products of the reaction. The almond enzyme was found to contain a flavin prosthetic group and the sorghum enzyme did not. Physical and kinetic characteristics of the two hydroxynitrile lyases were compared and were found to be quite different.