gebhart/patrepeval huggingface dataset:
Prognostic significance of plasma chromogranin A levels in hormone-refractory prostate cancer patients treated on Cancer and Leukemia Group B (CALGB) 9480 (2004)

4557 Background: The extent of neuroendocrine differentiation in prostate cancer correlates with aggressive disease and progression to hormone refractory prostate cancer (HRPC). Elevated plasma chromogranin A (CgA) levels in prostate cancer patients may reflect more extensive neuroendocrine phenotype. We therefore sought to test the hypothesis that CgA levels are of prognostic value in patients with HRPC. Methods: Pretreatment plasma was collected from 390 patients with metastatic HRPC enrolled in CALGB 9480, a study of 3 different dose levels of suramin. Plasma CgA levels were determined in 321 of the samples in duplicate using a quantitative sandwich immunoassay (DAKO Corp. Carpinteria, CA, Cat. No. K0025). The proportional hazards model was used to assess the prognostic significance of CgA in predicting overall survival. Results: Plasma CgA levels ranged from 7.7–19.3 U/L, with a median level of 12 U/L. In univariate analysis plasma CgA levels inversely correlated with survival times at the median CgA level, CgA ≤ 12 versus > 12 with survival 17 months (95% CI 14–19) compared to 11 months (95% CI 8–14, p = 0.014) and at all exploratory cut points including CgA ≤ 9.5 versus > 9.5 with survival 19 (95% CI= 16–20) months compared to 12 months (95% CI= 9–14, p = 0.002). In multivariate models adjusting for performance status, prostate specific antigen, lactate dehydrogenase (LDH), plasma CgA levels remained predictive of overall survival. The hazard ratio was 1.326 for patients whose CgA levels were above 9.5 compared to patients whose levels were < 9.5 (95% C.I. 1.045–1.68, p-value 0.020). Conclusion: These results support the hypothesis that plasma CgA levels can predict outcome in HRPC patients. No significant financial relationships to disclose.
SALMONELLOSIS AT RURAL AND URBAN CLINICS IN BANGLADESH (1982)

The authors studied the frequency of diarrheal illness associated with non-typhi Salmonella at two clinics in Bangladesh for the years 1977-1979. Non-typhi salmonellae were isolated from 0.29% of fecal specimens or rectal swabs in an urban area and 0.26% of similar specimens in a rural area; the frequency of isolations peaked in the summer months. Isolations of Shigella and Vibrio cholerae were much more common than Salmonella. Only two of 50 Salmonella isolates were resistant to more than one antibiotic. None of 13 isolates tested produced an enterotoxin. S. java and S. virchow accounted for 64% of all the isolates. Patients with diarrheal illness associated with isolation of Salmonella frequency had vomiting (88%), watery diarrhea (78%), abdominal pain (61%), and fever (39%), but the clinical features of the illnesses and the socioeconomic backgrounds of the patients could not be distinguished from those of matched controls who were attending the same clinic. The infrequency of Salmonella infection in an area where several other bacterial and viral enteric diseases are hyperendemic requires further investigation.
A User Authentication Scheme Based on Fingerprint and USIM Card (2008)

The identity authentication scheme based on symmetrical algorithm in 3G communication, cannot satisfy a high level of security demand of Beyond 3G (B3G). We propose an identity authentication scheme based on the PIN code, fingerprint characteristics and universal subscriber identity module (USIM) card. This solution makes full use of RSA's cryptosystem and hash algorithm, realized mutual identity authentication among the USIM card, the user and the network center. The random factor is generated by the mutual parties to guarantee the authentication fairness. Pre-calculation is used in user ends to reduce the real-time calculation and make the scheme satisfy real-time requirement of mobile communication system. Our scheme is suitable for applications with high security requirement.
Schlafen 11 (SLFN11), a putative predictive biomarker of platinum/PARPi response, is frequently detected on circulating tumor cells (CTCs) in advanced prostate cancer. (2021)

e17039 Background: Schlafen 11 (SLFN11) is a DNA repair protein (DNA/RNA helicase homology) that is recruited to stressed replication forks and leads to cell death. Recent ph II trial data in Extensive Stage Small-Cell Lung Cancer (ES-SCLC) [Byers et al. JCO 2018 PMID: 29906251] and a retrospective analysis of Circulating Tumor Cells (CTCs) and tumor tissue in patients (Pts) with advanced prostate cancer [Conteduca et al. Mol Cancer Therapeutics 2020 PMID: 32127465] suggested that SLFN11 expression predicts sensitivity to DNA damage targeting agents. In both contexts, metastatic tumor biopsies may not provide adequate material for profiling. We assessed the frequency of SLFN11 expression in CTCs isolated from blood in men with progressing metastatic Castration Resistant Prostate Cancer (mCRPC) and related expression to Homologous Recombination Repair (HRR) alterations identified in metastatic tumor biopsies profiled by MSK-IMPACT. Methods: 95 patients with progressing mCRPC about to start a new systemic therapy who had undergone pre-treatment metastatic tumor profiling by MSK-IMPACT and a matched blood draw for CTC profiling were selected. Blood was sent overnight to Epic Sciences and processed onto glass pathology slides and bio-banked until analysis. Detected CTCs (cytokeratin (CK) positive and leukocyte (CD45) negative) were analyzed for SLFN11 protein expression by immunofluorescence and correlated to Homologous Recombination Repair (HRR) alterations in metastatic biopsy from the bone, lymph node, or visceral metastases (15 PROFOUND genes). A mean of 1.2 mL of blood was analyzed per patient. Results: CTCs with SLFN11 expression (DAPI+, CK+, CD45-, SLFN11+) were detected in 28.4% (27/95) of the patient sample analyzed. SLFN11 signal was found to overlap with the nuclear DAPI signal. Individual CTC expression of SLFN11 in a sample was heterogeneous and ranged from a minimum of 2.9% to 100%. Seven of 10 (70%) of patients with a BRCA1/2 or ATM alteration had a least one SLFN11 expressing CTC. In contrast, in patients with other HRR alterations, only 20% (1/5) had CTCs with SLFN11. Sequencing of single CTCs is ongoing. Conclusions: SLFN11 expression is detected with high frequency in CTCs in men with progressing mCRPC. In whom CTCs are detected, the majority of patients with BRCA1/2 or ATM altered tumors also had SLFN11 expressing CTCs. The results support the prospective evaluation of CTC SLFN11 expression as a predictive biomarker for PARPi or platinum agents.
Providing robots with problem awareness skills (2012)

Humanoid robots operating in the real world must exhibit very complex behaviors, such as object manipulation or interaction with people. Such capabilities pose the problem of being able to reason on a huge number of different objects, places and actions to carry out, each one relevant for achieving robot goals. This article proposes a functional representation of objects, places and actions described in terms of affordances and capabilities. Everyday problems can be efficiently dealt with by decomposing the reasoning process in two phases, namely problem awareness (which is the focus of this article) and action selection.
ChemInform Abstract: Asymmetric Reductions with Freely and Non‐Freely Rotating Amide Group NADH Models. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Uniaxial and Triaxial Stress-Strain Behaviour of Ductile Cement Pastes Reinforced With Wollastonite Microfibers (2013)

When an oil well is submitted to cyclic steam injection the heating process induces tensile stresses in the cement sheath due to the thermal gradient that take place leading to cement-steel debonding and/or cement cracking. Similar problem can occur if the cement sheath is submitted to high creep deformations coming from the adjacent rock (this is the case for example of oil exploration in salt domes). In both cases sheath cracking can result in loss of hydraulic isolation and consequently in excessive water production with undesired economic and environmental consequences. In order to deal with this challenging scenario oil well cementing systems of special properties (e.g. high tensile strength, low elastic modulus and elevated toughness) should be used as an alternative to conventional high compressive strength systems. In this study cement pastes of high ductility were developed using wollastonite micro-fibers as reinforcement. The mixtures were developed within the framework of the Compressive Packing Model [1] and wollastonite microfibers were added in volume fractions of 2.5, 5.0 and 7.5 %. Uniaxial and triaxial compressive tests were carried out to obtain the unconfined and confined stress-strain behavior of the composites. The crack initiation stress and strain and the fracture process of the pastes under unconfined stress will be reported in this paper. Triaxial tests were performed under confining pressures of 0, 600 and 1200 psi and the Mohr-Coulomb criteria assumed to determine the internal frictional angle and cohesion. The results show that the addition of wollastonite microfibers increased the compressive strength of the pastes keeping the same strain capacity of the matrix. The internal frictional angle was also increased with the increase in the fiber volume fraction. However, the cohesion of the paste was reduced with the fiber addition.
Mathematical analysis of two‐phase flow in low‐permeability porous media (1989)

Abstract A one‐dimensional isothermal transient two‐phase flow model of gas and liquid in a low‐permeability medium has been developed from the general mass and momentum balances. The characteristic roots of the governing differential equations are real and distinct. Therefore, solution of the flow equations may be attempted by a stable initial‐value finite‐difference scheme. A numerical solution was obtained using the method of lines. Calculated two‐phase flow parameters are consistent with expected flow behavior and reflect the sensitivity of fluid flow to porosity, gas and liquid permeability, and capillary pressure in a tight sands porous medium. Calculated gas flow rates compared well with experimental data obtained at the Institute of Gas Technology (IGT) for low‐permeability sandstone.
Synthesis of dibenzothiophene-based host materials with a dimesitylborane substituent and their green PHOLED performances (2015)

In the two isomeric dibenzothiophene-based host materials, the different linkages between dibenzothiophene and dimesitylborane on a phenyl spacer dictated their photophysical properties. The performances of Ir(ppy)2(acac)-based green phosphorescent devices with two isomeric host materials were similar regardless of different linkage positions.
Mobility Analysis for Inter-Site Carrier Aggregation in LTE Heterogeneous Networks (2013)

In this paper we analyze the mobility performance for an LTE Heterogeneous Network with macro and pico cells deployed on different carriers. Cases with/without downlink inter-site carrier aggregation are investigated. Extensive system level simulations are exploited to quantify the performance. It is shown that not only does the use of inter-site carrier aggregation offer higher end-user throughput, but also several benefits in terms of improved mobility performance. Among others, it is shown that the performance becomes less sensitive to the setting of mobility parameters when inter-site carrier aggregation is used, while still keeping the handover signaling burden at an acceptable level. The probabilities of radio link failures, handover failures, and unnecessary handovers (also known as ping-pongs) are kept at a minimum for proposed the solution.
An immunohistochemical Study on the Pancreatic Endocrine Cells of the C57BL/6 Mouse (2002)

The regional distribution and relative frequency of the pancreatic endocrine cells in the C57BL/6 mouse were studied by immunohistochemical method using four types of specific mammalian antisera against insulin, glucagon, somatostatin and human pancreatic polypeptide (PP). The pancreas of mouse could be divided into three portions; pancreatic islets, pancreatic duct and exocrine portions, and pancreatic islets were further subdivided into three regions (central, mantle and peripheral regions) according to their located types of immunoreactive cells and pancreatic duct portions were also subdivided into two regions (epithelial and connective tissue regions). In the pancreatic islet portions, although some cells were also demonstrated in the mantle regions, most of insulin-immunoreactive cells were located in the central regions and they were randomly dispersed in the whole pancreatic islets. Glucagon-immunoreactive cells were detected in the mantle and peripheral regions. Their relative frequencies in the peripheral regions were somewhat numerous than those of the mantle regions. Somatostatin-immunoreactive cells were detected in the mantle and peripheral regions. However, no PP-immunoreactive cells were demonstrated in the pancreatic islets of C57BL/6 mouse. In the pancreatic duct portions, rare glucagon-immunoreactive cells were situated in the epithelial regions. Cell clusters that consisted of glucagon- or somatostatin- immunoreactive cells were found in some case of connective tissue regions of pancreatic ducts. However, insulin- and PP-immunoreactive cells were not detected in the epithelial nor connective tissue regions. In the exocrine portions, all four types of immunoreactive cells except for PP cells were demonstrated in the C57BL/6 mouse. However, no PP-immunoreactive cells were demonstrated. In conclusion, regional distribution of endocrine cells in the pancreas of C57BL/6 mouse was similar to that of mammals, especially other rodents except for topographically different distribution of endocrine cells compared to that of other rodents.
Thermodynamic properties of binary mixtures containing of hydrofluorocarbons and hydrofluorolefins: new data and modelling (2018)

Hydrofluorolefins (HFOs) are a new class of more environmentally-friendly refrigerant with zero ozone depletion potential, low global warming potentials, and low flammability. In this work, thermophysical property data for equimolar mixtures of HFOs (specifically R1234yf and R1234ze(E)) and hydrofluorocarbons (R32, R125, R134a, R143a, and R152a) are presented. Our measurements were combined with literature data available for these binary mixtures to optimize the mixture parameters in the models used in NIST REPFROP 9.1 and thereby improve thermodynamic property predictions for mixtures of HFO and HFC refrigerants. Significant improvements in the predicted properties were achieved, particularly for the density where, for the example of (R143a + R1234yf), the deviation of the model from the data was reduced from over 1 % to 0.06 %. The measurements and modelling conducted in this work should allow the more accurate simulation of refrigeration processes using mixtures of these refrigerants.
An experimental study of reducing narrowband noise of a slat using chevrons (2012)

A new concept of reducing the noise of a slat by applying a chevron form to the bottom edge is experimentally verified. The results of parametric studies are presented, which have been carried out on a small-scale model of a part of the wing (a scale of 1: 18) with deflected high-lift devices (the slat and the flap) in the landing configuration. As a result of acoustic measurements, a decrease (up to 4.5 dB) in narrowband noise for some chevron geometries is observed in comparison to a usual slat. The value of the decrease is a complex function of frequency, the wing and slat geometry, and the flow characteristics.
Identification of differentially expressed proteins in human glioblastoma cell lines and tumors (2003)

An in-frame deletion of 801 bp in exons 2-7 (type III mutation) of the epidermal growth factor receptor (EGFR) is detected at high incidence in primary glioblastoma tumors. A proteomic approach was used to generate differential protein expression maps of fetal human astrocytes (FHA), human glioblastoma cell lines U87MG and U87MG expressing type III EGFR deletion (U87MGdeltaEGFR) that confers high malignancy to tumor cells. Two-dimensional gel electrophoresis followed by in-gel digestion of separated spots and protein identification by LC-MS-MS and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) identified 23 proteins expressed at higher levels or exclusively in FHA and 29 proteins expressed at higher levels or exclusively in U87MG cells. Three proteins, ubiquitin, cystatin B, and tissue transglutaminase (TTG), were upregulated in U87MGdeltaEGFR relative to U87MG. Four proteins highly expressed by U87MG cells, Hsp27, major vault protein, TTG, and cystatin B, were analyzed by Western blot, ELISA, or RT-PCR in cell extracts and in tissue samples of glioblastoma multiforme (GBM; grade IV), low-grade astrocytomas (grades I and II), and nonmalignant brain lesions. All four proteins were highly expressed in GBM tissues compared to nonmalignant brain. These proteins may be used as diagnostic or functional (e.g., multiple drug resistance, invasiveness) markers for glioblastoma tumors.
Four crossmatch methods to select platelet donors (1984)

We employed four crossmatch techniques to select platelet donors for refractory patients. Forty-four donor-recipient pairs were studied in 32 patients. Analysis of effectiveness of platelet transfusions revealed that only 18 percent of transfusions gave a borderline response; the remainder were either effective or not effective at all. The corrected predictive values of three crossmatch tests were as follows: enzyme-linked immuno-specific assay, 81 percent; platelet immunofluorescence test, 73 percent; and lymphocytotoxicity, 70 percent (p greater than 0.05). The predictive value of these tests did not differ in HLA-matched versus unmatched platelet transfusions. Donor selection by lymphocytotoxicity compatibility did not appear to be useful if donors were selected by either of the other two methods. The fourth test, antiglobulin-modified lymphocytotoxicity, offered no advantage over lymphocytotoxicity. Our data suggest that platelet crossmatching assays are a useful adjunct to the selection process for the platelet donor in addition to ABO, Rh, and HLA matching.
Coupled Acoustic-Structural-Piezoelectric Modeling of Synthetic Jet (2014)

Synthetic-jet actuators (SJA) have been employed in a variety of roles including aerodynamic boundary layer control. In their most widespread configurations, these zero net mass-flow devices are actuated by a piezoelectric, periodically-oscillating which alternatively admits and then expels a gas from an enclosed cavity through a nozzle. The cyclic fluid motion in and out of the cavity forms a synthetic outward bound jet. The aim of the current paper is to present the development and validation of a modeling procedure based on finite elements, which includes multiphysics simulation. The SJA model was based on fully-coupled acoustic, structural and piezoelectric modeling. The predicted results were favorably compared to experiment. While coupled fluid-structural piezoelectric models are available, the proposed method is a much more convenient quick-design tool for SJA’S due to reduced computational times based onthe acoustic fluid approximation.
High performance data management and analysis for tomography (2014)

The Advanced Light Source (ALS) is a third-generation synchrotron X-ray source that operates as a user facility with more than 40 beamlines hosting over 2000 users per year from around the world. Users of the Hard X-ray Micro-Tomography Beamline (8.3.2) often collect more than 1 Terabyte of raw data per day that in turn generates additional Terabytes of processed data. The data rate continues to increase rapidly due to faster detectors and new sample automation capabilities. We will present the development and deployment of a computational pipeline, fed by data from the ALS, and powered by the storage, networking, and computing resources of the local National Energy Research Scientific Computing Center (NERSC) and the Energy Sciences Network (ESNET). After one year of operation, the system contained 70,000 datasets and 350 TB of data from 85 users. All datasets now collected at the Hard X-ray Tomography Beamline are automatically reconstructed using parameters set by users and/or that are automatically detected from the data acquisition control system. Results are presented to users for visualization through a secure web portal. Users can then download their data or launch a (currently limited but) growing number of operations based on the data-such as filtering, segmentation, and simulation. The massive computational resources of NERSC are thus made available on a level that is easily accessible to the full range of micro-tomography users.
Coastal Ocean Optical Properties in Santa Barbara Basin: Blooms & Plumes (1997)

Abstract : Our primary goals are (1) to accurately model the optical properties of Case II waters in order to estimate the respective contributions and fluxes of biogenic and terrigenous material, and (2) to develop algorithms for the optical characteristics of Case II waters for comparison and testing with the recently launched SeaWiFS satellite.
A convenient copper-catalyzed direct amination of nitroarenes with O-alkylhydroxylamines (1999)

O-Alkylhydroxylamines, particularly O-methylhydroxylamine, aminate nitroarenes in the presence of a strong base and a copper catalyst to give aminonitroarenes in good yields. ortho- or para-Amination with respect to the nitro group takes place, and in some cases the ortho-aminated product is preferentially obtained. With 3-substituted nitrobenzenes where the substituent has a lone pair of electrons, preferential amination occurs at the 2-position to give the sterically most congested 3c–f, 14 and 22g.