gebhart/patrepeval huggingface dataset:
Procyanidin effects on oesophageal adenocarcinoma cells strongly depend on flavan‐3‐ol degree of polymerization (2008)

Epidemiological studies have shown that the risk of developing oesophageal adenocarcinoma (OA) is inversely correlated to consumption of fruits and vegetables. Flavan-3-ols are the most abundant subclass of flavonoids in these types of foods. Three apple-derived procyanidin fractions with different average degrees of polymerization (aDP) were characterized and the effects of these fractions and of pure flavan-3-ol monomers ((-)-epicatechin and (+)-catechin) and dimers (B1, B2) on two OA cell lines were investigated. Flavan-3-ol monomers and dimers had no effect on the two cell lines, while apple-derived flavan-3-ol oligomers and polymers induced a time-dependent reduction of cell viability. The reduction in the cell viability was due to the induction of caspase-mediated apoptosis and an arrest of the cell cycle in G0/G1. The magnitude of the reduction in cell viability and induction of apoptosis after exposure to flavan-3-ol oligomeric/polymeric fractions positively correlated with their aDP. These results indicate that only flavan-3-ol oligomers and polymers, but not monomers and dimers, have an effect on the proliferation of OA cells in vitro. As tested flavan-3-ol concentrations are achievable through diet, this study suggests that apple-derived PA may possess chemotherapeutic effects against OA.
Simulation Study of Thin-Body Ballistic n-MOSFETs Involving Transport in Mixed $\Gamma$-L Valleys (2013)

Transistor designs based on using mixed Γ-L valleys for electron transport are proposed to overcome the density of states bottleneck while maintaining high injection velocities. Using a self-consistent top-of-the-barrier transport model, improved current density over Si is demonstrated in GaAs/AlAsSb, GaSb/AlAsSb, and Ge-on-insulator-based single-gate thin-body n-channel metal-oxide-semiconductor field-effect transistors. All the proposed designs successively begin to outperform strained-Si-on-insulator and InAs-on-insulator (InAs-OI) in terms of ON-state currents as the effective oxide thickness is reduced below 0.7 nm. InAs-OI still exhibits the lowest intrinsic delay (τ) due to its single Γ valley.
The Electrolytic Formation and Dissolution of Oxide Films on Platinum (1960)

The extent of surface oxidation of a smooth platinum electrode and the electrode capacitance were measured for various conditions of anodization. The electrolytic formation of the surface platinum oxide is shown to be a highly irreversible reaction. A mechanism which involves a hydroxyl radical intermediate of the oxygen evolution reaction is proposed for the surface oxide formation reaction. This mechanism is supported by the shapes of the anodic and cathodic charging curves on platinum and the interrelationships of the electrode potential, the electrode capacitance, and the extent of surface oxidation. From these same interrelationships it was also concluded that the steady‐state evolution of oxygen occurs on a surface which has at least one atom of oxygen per surface platinum atom and that the rate‐determining step in the oxygen evolution reaction is the electrolytic discharge of oxygen‐containing radicals which are adsorbed on the electrode surface. The surface oxide is reduced at potentials several hundred millivolts cathodic to the potential required to form the oxide. The reduction of the surface oxide is shown to be a first order reaction. The rate of the reduction increases with increasingly cathodic electrode potential.
A Voltage-Mode Design for a Spectrum Channelizer with PWM-LO Based Sub-band Gain Control (2022)

A spectrum channelizer employing a frequency-folded analog-to-digital converter (FF-ADC) architecture with the ability to control the amplitude of LO harmonics using pulse-width-modulated LOs (PWM-LOs), that uses voltage-mode downconversion is described in this work. The approach requires a single voltage-mode input amplifier to drive the downconversion switches. Frequency-folding and sub-band gain control are achieved in a single signal path. This is in contrast to prior work that used a current-mode approach, and required a main FF-ADC path and a separate auxiliary path for sub-band gain control. By avoiding the requirement for an auxiliary input path, the approach presented here is shown to significantly simplify the signal chain, with identical gain-scaling capability.
Fatigue strengthening of riveted girders in a historic railway metallic bridge in Switzerland using pre-stressed un-bonded CFRP laminates (2016)

In this paper, the applicability of the constant life diagram (CLD) methodology for fatigue strengthening of metallic members is examined. The CLD methodology is a method that uses the combined effect of alternating stress, mean stress and material properties to predict the material life-time under high-cycle fatigue loading. The method could be used most efficiently to improve resistance to crack initiation in ‘safe-life’ members, which is, in fact, a preventive fatigue strengthening approach (Ghafoori et al. 2015a). Furthermore, an innovative pre-stressed un-bonded reinforcement (PUR) system is presented. The advantages of the developed PUR system are: applicable to unsmooth surfaces (e.g., riveted or corroded), fast on-site installation (i.e., no glue and no surface preparation), no damage on metallic member (no weld, hole or grinding) and adjustable carbon fiber-reinforced polymer (CFRP) pre-stress level, as shown in Figure 1. Figure 1 Different components of the retrofit system: (a) the pre-stressing chair includes a saddle that pushes the CFRP away from the beam and (b) once the required eccentricity is reached, two column plates are placed between the CFRP plates and the saddle. More details about the design of the trapezoidal PUR system are described in (Ghafoori and Motavalli 2015). https://s3-euw1-ap-pe-df-pch-content-public-p.s3.eu-west-1.amazonaws.com/9781315207681/cd556cd4-4dcf-4efe-8e29-56fc67b8bfbd/content/fig61_1.tif"/> The system can be easily disassembled and removed, if necessary, which makes it suitable for historical bridges as a temporary or permanent retrofit technique. Lastly, this paper presents details about fatigue strengthening of riveted girders in a 120-year-old railway (wrought iron) bridge using the PUR system (see Fig. 2) such that the requirements of the CLD approach are fulfilled. Figure 2 A strengthened crossbeam of Münchenstein Railway Bridge. A strain gauge is glued to each CFRP plate and is connected to the wireless sensor network (WSN) system for long-term monitoring of the pre-stress level (Ghafoori et al. 2015b). https://s3-euw1-ap-pe-df-pch-content-public-p.s3.eu-west-1.amazonaws.com/9781315207681/cd556cd4-4dcf-4efe-8e29-56fc67b8bfbd/content/fig61_2.jpg"/>
Alice (1996)

Research Article| November 01 1996 Alice Paul Schmidt Paul Schmidt Search for other works by this author on: This Site Google Theater (1996) 26 (3): 27–50. https://doi.org/10.1215/01610775-26-3-27 Cite Icon Cite Share Icon Share Facebook Twitter LinkedIn MailTo Permissions Search Site Citation Paul Schmidt; Alice. Theater 1 November 1996; 26 (3): 27–50. doi: https://doi.org/10.1215/01610775-26-3-27 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search Books & JournalsAll JournalsTheater Search Advanced Search You do not currently have access to this content.
Generation of human induced pluripotential stem cells from individuals with complex heterozygous, isogenic corrected, and homozygous Bloc1s1 mutations (2022)

Genetic studies show that BLOC1S1 modulates mitochondrial and endosome-lysosome function (Wu et al., 2021a). Furthermore, Bloc1s1 mutations are linked to leukodystrophy (Bertoli-Avella et al., 2021). The Vanderver laboratory identified additional individuals with leukodystrophy that harbored either complex heterozygous (Bloc1s1 c.206A > C and c.359G > A), or homozygous (Bloc1s1 c.185 T > C) point mutations. We generated induced pluripotential stem cell (iPSC) lines from these subjects, from parents of the complex heterozygous mutations patient, and from CRISPR isogenic (c.206A > C and c.359G > A) corrected iPSC-line. These complex heterozygous, homozygous, and isogenic-corrected Bloc1s1 lines were phenotypically normal and were capable of differentiation towards the three germ layers.
Hybrid wireless networks with FIB-based Named Data Networking (2017)

In Named Data Networking (NDN) architecture, packets carry data names rather than source or destination addresses. To realize this paradigm, each NDN router maintains three data structures CS, PIT, FIB in the forwarding plane. Designing a quick enough forwarding plane with high capacity is a major challenge within the overall NDN research area. In this paper, we present a novel implementation of FIB called MaFIB. The evaluations indicate that the excellent data structure and the efficient lookup algorithm of MaFIB can effectively reduce the memory cost and can accelerate the lookup process. Its outstanding performance in probability of false positive also makes MaFIB meet current network requirements.
Inertial long-stroke linear actuator for low-frequency vibration control (1998)

Force actuators used for vibration control, such as shakers and proof-mass actuators, typically use single-phase electromagnetic linear motors that have a range of travel limited to a few inches. For proof-mass actuators, the stroke limitation can be especially constraining because it also limits the force output of the actuator at low frequencies. To overcome this low output at low frequency, we have developed an inertial, long stroke, linear actuator (ILSLA). The ILSLA is built around a three-phase linear motor that is driven by a commutating amplifier to achieve strokes of almost unlimited length. Vibration control applications that can benefit from this technology include precision space structures and large- scale robots.
Production of Monoclonal Antibodies (2006)

This unit describes the production of monoclonal antibodies beginning with immunization and cell fusion and selection. Support protocols are provided for screening primary hybridoma supernatants for antibodies of desired specificity, establishment of stable hybridoma lines, cloning of these B cell lines by limiting dilution to obtain monoclonal lines, and preparation of cloning/expansion medium. An alternate protocol describes cell fusion and one-step selection and cloning of hybridomas utilizing a semi-solid methylcellulose-based medium (ClonaCell-HY).
Blockchain and Cryptocurrency: A comparative framework of the main Architectural Drivers (2018)

Blockchain is a decentralized transaction and data management solution, the technological weapon-of-choice behind the success of Bitcoin and other cryptocurrencies. As the number and variety of existing blockchain implementations continues to increase, adopters should focus on selecting the best one to support their decentralized applications (dApps), rather than developing new ones from scratch. In this paper we present a framework to aid software architects, developers, tool selectors and decision makers to adopt the right blockchain technology for their problem at hand. The framework exposes the correlation between technological decisions and architectural features, capturing the knowledge from existing industrial products, technical forums/blogs, experts' feedback and academic literature; plus our own experience using and developing blockchain-based applications. We validate our framework by applying it to dissect the most outstanding blockchain platforms, i.e., the ones behind the top 10 cryptocurrencies apart from Bitcoin. Then, we show how we applied it to a real-world case study in the insurtech domain.
EFFECT OF FRICTION STIR PROCESSING PARAMETERS ON THE TENSILE STRENGTH OF SURFACE COMPOSITE ALUMINUM ALLOY. (2017)

In the current study, the surface composite sheet of AA2024/al203 has been fabricated using friction stir processing technique. The processing parameters during fabrication process; such as rotation speed,
Hybrid nonlinear surface-phonon-plasmon-polaritons at the interface of nolinear medium and graphene-covered hexagonal boron nitride crystal (2016)

The properties of hybrid nonlinear surface-phonon-plasmon-polaritons (SP3) at the interface of nonlinear medium and graphene-covered hexagonal boron nitride (hBN) are investigated theoretically. It is demonstrated that the hybrid nonlinear SP3 can be tuned by controlling the chemical potential, layer number and relaxation time of graphene. The real and imaginary parts of the propagation constant increase by decreasing the Fermi energy or the layer number of the graphene in the frequency outside of the upper Reststrahlen band of hBN. Moreover, we show that the nonlinear dielectric permittivity has great effect on the propagation constant. The real part of the propagation constant increases with positive nonlinear dielectric permittivity at different frequency for low frequency mode; while the imaginary part of the propagation constant decreases in the upper Reststrahlen band of hBN, keeps nearly constant in the lower band, and increases outside the Reststrahlen band with positive nonlinear dielectric permittivity for low frequency mode.
Using gradient-based algorithms to determine ground-state energies on a quantum computer (2022)

Variational algorithms are promising candidates to be implemented on near-term quantum computers. In our work, we investigate the variational Hamiltonian ansatz (VHA), where a parametrized trial state of the quantum mechanical wave function is optimized to obtain the ground-state energy. In the VHA, the trial state is given by a noninteracting reference state modified by unitary rotations using generators that are part of the Hamiltonian describing the system. The lowest energy is obtained by optimizing the angles of those unitary rotations. A standard procedure to optimize the variational parameters is to use gradient-based algorithms. However, shot noise and the intrinsic noise of the quantum device affect the evaluation of the required gradients. We study how different methods for obtaining the gradient, specifically the finite-difference and the parameter-shift rule, are affected by shot noise and the noise of the quantum computer. To this end, we simulate a simple quantum circuit, as well as the two-site and six-site Hubbard models.
SCATTERING ANALYSIS OF PERIODIC ARRAYS USING COMBINED CBF/P-FFT METHOD (2011)

In this paper, an improved CBFM/p-FFT algorithm is presented, which can be applied to solve electromagnetic scattering problems of large-scale periodic composite metallic/dielectric arrays, even when the array has electrically small periodicity or separating distance.
Pretreatment With TLR2 and TLR4 Ligand Modulates Innate Immunity in Corneal Fibroblasts Challenged WithAspergillus fumigatus (2013)

Pretreatment of THSFs with TLR2-specific ligand zymosan results in a state of A. fumigatus hyphae tolerance. Copretreatment with TLR2 and -4 ligands (zymosan and LPS) leads to a stronger state of A. fumigatus hyphae tolerance, and suppresses the lethal effect of A. fumigatus.
Allelic inactivation of rDNA loci (2009)

Human cells contain several hundred ribosomal genes (rDNA) that are clustered into nucleolar organizer regions (NORs) on the short arms of five different acrocentric chromosomes. Only approximately 50% of the gene copies are actually expressed in somatic cells. Here, we used a new cytological technique to demonstrate that rDNA is regulated allelically in a regional manner, with one parental copy of each NOR being repressed in any individual cell. This process is similar to that of X-chromosome inactivation in females. Early in development, one copy of each NOR becomes late-replicating, thus probably marking it for inactivation and subsequent targeted de novo methylation at rDNA promoter regions. Once established, this multichromosomal allelic pattern is then maintained clonally in somatic cells. This pathway may serve as an epigenetic mechanism for controlling the number of available rDNA copies during development.
Development of Tri-Stable Rotary Solenoid Actuator (2017)

We have designed and developed a tri-stable rotary solenoid actuator, which has a simple structure and simple operation. The plunger has two stabilities at the extreme positions along an angular stroke and the third stability at the center of it. The third has been successively achieved by using the electromagnetic restoring torque, which is designed to be larger than the inertia torque. The dynamic characteristics were determined by utilizing an optimal design program that is specially constructed based on the response surface method in order to design the coil winding and the power supply for the coil excitation. A prototype solenoid was constructed and used to verify the tri-stable motions and accuracy of the previously constructed design program.
Dissolved Oxygen Variations in Marine Fish Culture Zone (1991)

Extensive field measurements aimed at studying short‐term dissolved oxygen (DO) variability have been carried out in a marine fish culture zone in Hong Kong. A dynamic oxygen budget model is developed to analyze the diurnal water‐quality data from a series of 26‐hr surveys. The model formulation includes phytoplankton dynamics and photosynthetic production, sediment oxygen demand (SOD), fish respiration, carbonaceous and nitrogenous oxidation, and atmospheric oxygen transfer. The model is used to determine the components of oxygen consumption and production—in particular, the SOD and carbon‐to‐chlorophyll (CCHL) ratio. It is found that SOD and algal respiration are major oxygen consumption items, and the CCHL ratio is much higher than reported in previous mathematical model studies. Simulations of the diurnal DO variation are compared with data over a wide range of meteorological and ecological conditions. The model interpretation provides a basis for the formulation of a water‐quality model for short‐term DO forecasts
catena-Poly[{μ3-3,3′-[(1,7-dioxa-4,10-diazacyclododecane-4,10-diyl)bis(methylene)]dibenzoato}cobalt(II)] (2013)

The title compound, [Co(C24H28N2O6)] n , crystallizes as infinite chains related to one another by inversion centers, giving a centrosymmetric coordination polymer. The Co(II) ion, situated on a twofold rotation axis, forms a complex with the crown-4 moiety of the 3,3'-[(1,7-dioxa-4,10-di-aza-cyclo-do-decane-4,10-di-yl)bis-(meth-ylene)]dibenzoate anion. The dis-torted octahedral coordination sphere of the Co(II) ion is completed by two carboxyl-ate O atoms from two bridging intra-chain ligands. Metallomacrocyclic rings of 16 atoms are present, with each ring containing two Co(II) ions and 14 atoms from the bridging ligands. These units repeat as infinite zigzag chains along [101].
Melting Curve and Liquid Structure of Nitrogen Probed by X-ray Diffraction to 120 GPa (2017)

Synchrotron x-ray diffraction measurements of nitrogen are performed up to 120 GPa to determine the melting curve and the structural changes of the solid and liquid phases along it. The melting temperature exhibits a monotonic increase up to the triple point where the epsilon molecular solid, the cubic gauche covalent solid, and the fluid meet at 116 GPa, 2080 K. Above, the stability of the cubic gauche phase induces a sharp increase of the melting curve. The structural data on liquid nitrogen show that the latter remains molecular over the whole probed domain, which contradicts the prediction of a liquid-liquid transition at 88 GPa, 2000 K. These findings thus largely revisit the phase diagram of hot dense nitrogen and challenge the current understanding of this model system.
Changing Less-Preferred Duties to More-Preferred: A Potential Strategy for Improving Supervisor Work Enjoyment (2008)

ABSTRACT We evaluated a strategy for making highly nonpreferred work duties more preferred as a potential means of enhancing work enjoyment among supervisors in a human service setting. Repeated preference ratings and rankings were completed by 4 supervisors during baseline to identify their most disliked work tasks. These tasks were then altered by soliciting each supervisor's opinion regarding why the respective task was so disliked and what could be done to make the task more preferable, removing disliked stimuli associated with the tasks, and adding liked stimuli during completion of the tasks. Following the task alterations, ratings of task likeability increased for all 4 supervisors. Preference rankings of target tasks also increased, including from rankings as among the least preferred tasks to among the most preferred tasks. All supervisors rated the task-alteration process as making their quality of work life better, and all chose to continue the intervention. These results occurred without any observed decrease in work quality. Results are discussed regarding the potential contribution of behavioral interventions with subjective concepts, such as enjoyment, that are viewed as important by the general populace. However, qualifications with relying on verbal reports also are noted.
Characterization of calves exhibiting a novel inheritable TNF-α hyperresponsiveness to endotoxin: associations with increased pathophysiological complications (2005)

A subpopulation of calves, herein termed "hyperresponders" (HPR), was identified and defined by the patterns of plasma TNF-alpha concentrations that developed following two challenges with endotoxin (LPS, 0.8 mug Escherichia coli 055:B5 LPS/kg(0.75) live body wt) separated by 5 days. The principle characteristic of HPR calves was a failure to develop tolerance to repeated LPS challenge that was evident in the magnitude of the TNF-alpha concentrations and prolonged severity of pathological sequellae. Whereas calves failing to develop LPS tolerance were identified on the basis of their excessive in vivo plasma TNF-alpha concentration responses, in vitro TNF-alpha responses of peripheral blood mononuclear cells isolated from each calf and challenged with LPS or PMA did not correlate or predict the magnitude of in vivo plasma TNF response of the calf. Intentional breeding to obtain calves from bulls and/or cows documented as HPR resulted in offspring displaying the HPR character when similar progeny calves were tested with LPS in vivo, with extensive controls in place to account for sources of variability in the general TNF-alpha response to LPS that might compromise interpretation of the data. Feed intake, clinical serology and hematology profiles, and acute-phase protein responses of HPR calves following LPS were significantly different from those of calves displaying tolerance. These results suggest that the pattern of plasma TNF-alpha changes that evolve from a low-level double LPS challenge effectively reveal the presence of a genetic potential for animals to display excessive or prolonged pathological response to LPS-related stress and compromised prognosis for recovery.
Comparison of the life cycles of two populations of the polychaete Pereinereis cf. cultrifera from the Bay of Algiers (Mediterranean Sea) (2008)

The benthic phases of the life cycles of two populations of the polychaete Pereinereis cultrifera from the Bay of Algiers were investigated using field surveys. We found no differences in the life cycle of the two populations. In the Bay of Algiers, P. cultrifera reproduces without epitokal modifications. The lifespan of the species probably does not exceed two years. The reproductive period spans most of the year but is more intense in spring from March to May when the sea-water temperature starts rising. A few mature individuals were collected at the end of summer and in winter. The oocytes take 9 to 12 months to mature and their diameter at maturity is approximately 200 µm.