gebhart/patrepeval huggingface dataset:
Texture and Magnetic Properties (1989)

The magnetic properties of ferromagnetic materials are closely related to the crystallographic texture, i.e. the orientation distribution of the crystallites, they are, however, not uniquely determined by the texture. Higher order “textural quantities” such as, for instance, orientation correlation functions are additionally needed for a more complete description. The properties in saturation are uniquely determined by the texture. They can be expressed by a fourth—or sixth—order approximation of the texture function which can be obtained by “low resolution” texture measurements. On the other hand, magnetic anisotropy measurements can only provide a low‐resolution approximation to the texture function and not the complete function. The distribution of magnetization directions can be described by a “magnetic texture” which can be calculated from pole figures measured by neutron diffraction using the method of superposed pole figures.
Influence of the chemistry of vitrified residues on the properties of blended inorganic polymers with calcined kaolinitic clay (2015)

status: Published
Biomarkers for predicting the outcome of Puumala hantavirus infection (2012)

Hantaviruksiin kuuluva Puumala-virus aiheuttaa lievän munuaisoireisen verenvuotokuumeen, myyräkuumeen. Taudin vaikeusaste vaihtelee oireettomasta kuolemaan johtaviin tapauksiin, jotka ovat kuitenkin harvinaisia. Myyräkuumeen taudin kehittymistä ei täysin tunneta, mutta immunologisilla reaktioilla on arveltu olevan siinä tärkeä osuus. Väitöstutkimuksessa selvitettiin erilaisten immunologisten tekijöiden yhteyttä myyräkuumeen vaikeusasteeseen sekä arvioitiin niiden mahdollista osuutta taudin kehittymisessä.\n\nKorkean IL-6-pitoisuuden todettiin liittyvän vaikeaan myyräkuumeeseen ja olevan itsenäinen riskitekijä munuaisten vajaatoiminnalle.\n\nPitkän pentraksiinin PTX3:n pitoisuus oli koholla akuutissa myyräkuumeessa ja korkea pitoisuus oli yhteydessä vaikeaan taudinkuvaan, erityisesti matalaan verihiutaletasoon sekä myös komplementtijärjestelmän aktivaatioon. Tutkimuksen perusteella PTX3 voisi vaikuttaa matalan trombosyyttitason kehittymiseen myyräkuumeessa aktivoituneen komplementtijärjestelmän kautta.\n\nTryptofaania kataboloivan entsyymin IDO:n pitoisuuden todettiin olevan koholla akuutissa myyräkuumeessa ja korkea IDO oli yhteydessä vaikeaan tautiin sekä osoittautui merkittävän munuaisten vajaatoiminnan itsenäiseksi riskitekijäksi. IDO saattaa vaikuttaa munuaisten vajaatoiminnan kehittymiseen myyräkuumepotilailla aiheuttamalla tubulaaristen epiteelisolujen apoptoosia tai lamaamalla immuunijärjestelmää T-soluja estämällä.\n\nSoluvapaa DNA on peräisin apoptoottisista tai nekroottisista soluista ja siten kuvastaa solutuhon määrää erilaisissa sairauksissa. Plasman soluvapaan DNA:n pitoisuus todettiin koholla olevaksi akuutissa myyräkuumeessa. Se myös korreloi taudin vaikeuteen mm. sairaalahoidon kestolla arvioituna. Virtsan soluvapaan DNA:n eritys puolestaan ei ollut myyräkuumeessa koholla eikä se korreloinut taudin vaikeusasteeseen. Siten virtsan soluvapaan DNA:n eritys ei kuvasta tulehduksen määrää munuaisissa.\n\nKorkea plasman CRP ei liittynyt vaikeampaan akuuttiin myyräkuumeeseen vaan päinvastoin osoittautui mahdolliseksi munuaisten toimintaa suojaavaksi tekijäksi. CRP ei siten sovellu seurantamerkkiaineeksi arvioitaessa taudin vaikeusastetta ja ennustetta myyräkuumepotilailla.
Lipid droplet evolution gives insight into polyaneuploid cancer cell lipid droplet functions (2021)

Lipid droplets (LDs) are found throughout all phyla across the tree of life. Originating as pure energy stores in the most basic organisms, LDs have evolved to fill various roles as regulators of lipid metabolism, signaling, and trafficking. LDs have been noted in cancer cells and have shown to increase tumor aggressiveness and chemotherapy resistance. A certain transitory state of cancer cell, the polyaneuploid cancer cell (PACC), appears to have higher LD levels than the cancer cell from which they are derived. PACCs are postulated to be the mediators of metastasis and resistance in many different cancers. Utilizing the evolutionarily conserved roles of LDs to protect from cellular lipotoxicity allows PACCs to survive otherwise lethal stressors. By better understanding how LDs have evolved throughout different phyla we will identify opportunities to target LDs in PACCs to increase therapeutic efficiency in cancer cells.
Uptake and Accumulation of the Herbicides Chlorsulfuron and Clopyralid in Excised Pea Root Tissue (1987)

The herbicides chlorsulfuron and clopyralid were taken up rapidly by excised pea root tissue and accumulated in the tissue to concentrations ten and four times those in the external medium, respectively. Uptake was related linearly to external herbicide concentration over a wide concentration range, implying that transport across the membrane is by nonfacilitated diffusion. Uptake of both compounds was influenced by pH, with greatest uptake at low pH. The pH dependence of uptake suggests that the herbicides (both of which are weak acids) are transported across the plasma membrane in the undissociated form, and accumulate in the cytoplasm by an ion trap mechanism. Most of the absorbed herbicide effluxed from the tissue when it was transferred to herbicide-free buffer, indicating that the accumulation was not due to irreversible binding. Consequently, both herbicides remain available for transfer to the phloem. These results can explain the high reported phloem mobility of clopyralid in intact plants. The low phloem mobility of chlorsulfuron must be accounted for by factors that override its ability to accumulate in the symplast.
Synthesis of AMP Analogs and Their Use for Studies on the Allosteric Site of Rabbit Muscle Glycogen Phosphorylase <italic>b</italic> (1977)

In order to obtain a better understanding of the allosteric site of rabbit muscle phosphorylase b, nine AMP analogs having a bulky hydrophobic benzene ring were synthesized and tested for activity as activators or inhibitors. N6-Benzyl-AMP derivatives activated phosphorylase b to the same extent as AMP but bound to the enzyme more tightly than AMP. N6-p-nitrobenzyl-AMP had the highest affinity (Ka = 7.7 X 10(-7) M) for the AMP site. In an attempt to irreversibly modify the allosteric site of phosphorylase b, N6-p-bromoacetaminobenzyl-AMP was synthesized. Phosphorylase b was maximally activated upon incorporation of 1.0 mol of N6-p-bromoacetaminobenzyl-AMP per enzyme subunit, and its activity was approximately 90% of that of native phosphorylase b measured in the presence of AMP. The modified enzyme showed characteristics (e.g., kinetic parameters, stability, solubility, inhibition by glucose-6-phosphate, and state of aggregation) quite similar to those observed for the native enzyme in the presence of AMP. These results indicate that the AMP site of phosphorylase was specifically labeled by N6-p-bromoacetaminobenzyl-AMP. The nature of the allosteric site of phosphorylase b is discussed based on the results obtained.
697-P: Insulin Pump Interoperability of the Diabeloop DBLG1 System (2021)

This study aims to assess the interoperability of Diabeloop’s DBLG1 Closed Loop System on glycemic control for T1D patients, based on data from clinical trials NCT02987556[1] (SP7) and NCT04190277 (SP8).SP7 study was conducted on 63 out of 68 patients randomly assigned to two arms equipped with DBLG1 system using Cellnovo pump for arm 1 and Kaleido pump for arm 2. All patients attended a 12-week open loop (OL) phase (receiving their usual treatment) and a 12-week closed loop (CL) phase (using DBLG1 system).In SP8 study, 178 out of 184 patients, randomly assigned to two arms, started with a 2-week baseline phase in OL. The next 12 weeks, patients in arm 2 remained in OL while patients in arm 1 switched to CL equipped with DBLG1 System using DANA Diabecare-i insulin pump. The study was shortened due to COVID-19 epidemic.To assess the improvement reached by DBLG1 System, we compared the average time in range 70-180 mg/dL (TIR) between OL and active CL phases. For SP7 study, we analysed data from both arms. For SP8 study, to assess the TIRs for the same patients, we compared baseline and CL phases for arm 1.As shown in Figure 1, for SP7 the average TIRs increased by 8.6% for arm 1 (32 patients) and by 14.0% for arm 2 (31 patients in CL, 30 in OL). For SP8 arm 1 the average TIR increased by 12.8% (142 patients).DBLG1 System improved the TIR despite the use of 3 different pumps. Therefore, improvement linked with DBLG1 System on the average TIR is independent of the pump used.View largeDownload slideView largeDownload slide DisclosureA. Adenis: Employee; Self; Diabeloop SA. L. Pou: Employee; Self; Diabeloop SA. H. M. Romero-ugalde: Employee; Self; Diabeloop SA. Y. Tourki: Employee; Self; Diabeloop SA. S. Franc: Advisory Panel; Self; Diabeloop SA, Board Member; Self; Novo Nordisk, Other Relationship; Self; Abbott Diabetes, Research Support; Self; Merck Sharp & Dohme Corp., Stock/Shareholder; Self; Diabeloop SA. G. Charpentier: Other Relationship; Self; Diabeloop. P. Y. Benhamou: Consultant; Self; Diabeloop SA, Eli Lilly and Company, Insulet Corporation, Other Relationship; Self; Abbott Diabetes. M. Doron: Research Support; Self; Diabeloop SA. E. Huneker: Employee; Self; Diabeloop SA.
Ultra-High-Resolution Differential Interference Microscopy of Ag Deposition on an Ultraflat Au(111) (2016)

The electrodeposition of silver on an atomically ultraflat surface of Au(111) was investigated using laser confocal microscopy combined with the differential interference contrast microscopy (LCM-DIM) in the sulfuric acid medium with silver sulfate as an electrolyte solution. For the first time, we have observed the underpotential deposition processes of silver atoms on the large Au(111) surface area in atomic height resolution of as-deposited Ag layers using LCM-DIM. In underpotential deposition (UPD) regions, small islands of Ag atoms with monatomic step heights are formed on the Au(111) terraces at the initial stage, followed by the increase in domain size of islands, and then finally a complete monolayer was formed on the Au(111) surface. Before initiating the bulk deposition of Ag, our LCM-DIM gave direct evidence for the formation of the third monolayer of Ag at the foot of the potential of the bulk deposition. In addition to UPD, the bulk deposition of Ag was also investigated which demonstrated that the very flat Ag surface appeared on the Au(111) surface. Finally, it has been demonstrated that the LCM-DIM was an ideal tool to capture images of the fast dynamic Ag electrodeposition processes on the Au(111) surface with the fastest acquisition times of 2–10 frames per second.
Mean and variance of the 3-D field forward propagated through random internal waves in continuously stratified deep and shallow water ocean waveguides (2005)

A general modal solution for the mean and covariance of an acoustic field propagating through 3-D random inhomogeneities in an ocean waveguide [Ratilal and Makris, J. Acoust. Soc. Am. 114, 2428 (2003)] is applied to propagation through a general 3-D internal wave field. Our previous two-layer internal wave parameterization is extended to continuous stratification and applied in both continental shelf and deep ocean waveguides. Physical and statistical properties of the internal waves are modeled with the Garret-Munk and other theoretical and empirical formulations. The mean and variance of the forward field propagating through internal waves is expressed in terms of the stochastic moments of the medium’s scatter function density. This is formulated with the Rayleigh-Born approximation to Green’s theorem in terms of the medium’s compressibility and density fluctuations. In this way, the effect of both internal-wave sound speed and density variations on the forward propagated field are quantified. Density variations are shown to greatly affect high order modal propagation in some cases. Two-dimensional models of propagation through random internal wave fields are shown to become inaccurate after exceeding threshold ranges where 3-D scattering becomes important.
Ion and electron bombardment-related ion emission during the analysis of diamond using secondary ion mass spectrometry (2007)

In recent years, the ability to grow single crystal layers of both doped and pure diamonds has improved, and devices for applications in high power electronics and microelectronics are being developed, most of them based on boron doped diamond. In this work, convoluted angular and energy spectra (so-called secondary ion mass spectrometry energy spectra) have been measured for B+11, C+12, O+16, CO+ and CO2+ ions ejected from a single crystal boron doped diamond layer under ultralow energy oxygen and electron beam bombardment. A low energy tail was observed in the C+12, CO+, and CO2+ signals, corresponding to ions produced in the gas phase. Changing the bombardment conditions, we have identified interaction with the electron beam as the main ionization mechanism. In the case of C+12 it appears that the gas phase ions are produced by electron stimulated desorption and postionization of surface species created by the oxygen beam. We have detected high signals for CO+ and CO2+ ionized in the gas phase, which supports a mechanism previously suggested to explain the anomalously fast diamond erosion under oxygen ion beam bombardment. We also observe that some species appearing in the mass spectrum are produced by electron stimulated desorption and this needs to be remembered when analyzing these on insulating diamond with charge compensation.
Transplantation of Fetal Mesencephalic Tissue in Parkinson's Patients (1994)

Patients with idiopathic Parkinson's disease who had become refractory to medical treatment underwent unilateral stereotactic transplantation of mesencephalic tissue obtained from 7- to 9-week-old postconception fetuses. Small pieces of tissue, less than 1 mm, were deposited in 9 sites in the putamen and 3 in the caudate. Patients were 4 men and 3 women and aged from 42 to 59 years (mean 50). Symptom durations were from 9 to 21 years (mean 14). The examinations were done at 3- to 4-month intervals pre- and postoperatively. Patients were examined for a minimum of 1 year postoperatively. The examinations consisted of neurological and general physical examinations, UCLA Parkinson's Disability Scale, Hoehn and Yahr rating and United Parkinson's Disease Rating Scale (PDRS), all in both 'on' and 'off' states. Video recordings and timed tests of a number of motor tests were performed. Patients also completed 7 consecutive days of hourly self-assessments prior to each visit. Fluorodopa PET scans were obtained pre- and 6 and 15 months postoperatively. The operations took place from mid-July 1992 to January 1993. Postoperative states have been free of complications. All have been on immunosuppressants. Levodopa was transiently decreased in the postoperative period, but raised to approximately the preoperative level thereafter. In late March 1993, 3 patients appeared to show modest improvement in the UCLA and UPDRS scales and in the patients' self-assessments.
Deuterium isotope studies on 2,3-dicarbahexaborane(8) (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDeuterium isotope studies on 2,3-dicarbahexaborane(8)John R. Spielman, Richard Warren, Gary B. Dunks, James E. Scott Jr., and Thomas OnakCite this: Inorg. Chem. 1968, 7, 2, 216–218Publication Date (Print):February 1, 1968Publication History Published online1 May 2002Published inissue 1 February 1968https://pubs.acs.org/doi/10.1021/ic50060a008https://doi.org/10.1021/ic50060a008research-articleACS PublicationsRequest reuse permissionsArticle Views14Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Challenges in the pharmaceutical development of lipid-based short interfering ribonucleic acid therapeutics (2012)

Discovering and developing a lipid-based siRNA therapeutic that can be commercialized requires engineering a particle that selectively and efficiently delivers the cargo to the target tissue and cellular compartment. The particle assembly must be strictly controlled and physical properties thoroughly characterized to successfully develop an understanding of particle attributes that influence in vivo pharmaceutical properties. Correlation of particle physio-chemical properties to product performance is the foundation for advancements in discovery and assuring quality in a commercial drug product. Although difficult, we believe these development challenges can be addressed with appropriate scientific resources and that the industry will continue to progress siRNA therapeutic candidates through clinical development.
Enhancing SAT-based equivalence checking with static logic implications (2004)

We propose a novel technique to improve SAT-based Combinational Equivalence Checking (CEC) by statically adding meaningful clauses to the CNF formula of the miter circuit. A fast preprocessing quickly builds up the implication graph for the miter circuit under verification, resulting in a large set of direct, indirect and extended backward implications. The non-trivial implications are converted into two-literal clauses and added to the miter CNF database. These added clauses constrain the search space, and provide correlation among the different variables, which enhances the Boolean Constraint Propagation (BCP). Experimental results on ISCAS'85 CEC instances show that with the added clauses, an average speedup of more than 950x was achieved.
Flight Test with an Adaptive Feed-Forward Controller for Alleviation of Turbulence Excited Wing Bending Vibrations (2009)

On large, and thus highly flexible airliners, atmospheric turbulence excited wing bending vibrations generally cause high dynamic loads in the wing roots and degrade the ride comfort. In the past, these problems have been tackled by the use of feedback control laws for active wing bending damping. Active wing bending damping reduces fatigue loads on the one hand, and reduces vertical accelerations in the cabin on the other. Additional feed-forward compensation of wing bending vibrations can provide further improvement of ride comfort and, assuming sufficient control authority, has the potential to also reduce peak loads. Best performance is obviously achieved by a combination of both active wing bending damping and feed-forward compensation of atmospheric turbulence excited wing bending vibrations. However, the performance of feed-forward control is very sensitive to plant uncertainties. Regarding wing bending vibration alleviation on large airliners, one major plant uncertainty is the fuel mass. A promising solution to overcome problems related to the sensitivity of performance in regards to plant uncertainties, is the adaptation of the feed-forward controller towards optimum performance using a least mean square algorithm. Such an adaptive feed-forward vibration control system has been successfully flight tested on the DLR ATTAS (Advanced Technologies Testing Aircraft System.) A reference for atmospheric turbulence was obtained by a nose boom mounted flight log sensor. Symmetrically commanded high bandwidth Direct Lift Control (DLC) flaps served as actuators. The obtained flight test data shows robust convergence of the adaptive feed-forward controller towards its optimum, as predicted by previous stability analysis of the adaptation algorithm. The ATTAS is a relatively small and stiff aircraft with a first wing bending frequency of 5 Hz. The converged feed-forward controller thus reduces the power spectral density of modal wing bending accelerations by only 20%, at least showing that the use of a conditioned alpha probe signal for compensation of atmospheric turbulence excited wing bending vibrations is feasible. A 20% reduction in terms of the power spectral density is not much, but the result is well in accordance with performance estimates drawn from rough calculations with the two-dimensional von Karman turbulence model. The same model predicts a 75% reduction of the power spectral density of modal wing bending accelerations (50% reduction of the magnitude of modal wing bending accelerations respectively) for large airliners where the first wing bending frequency lies at about 1 Hz. A 50% reduction of the magnitude of modal wing bending accelerations is comparable to what is achievable with active wing bending damping control systems today, thus showing that for large airliners the proposed feed-forward compensation of atmospheric turbulence excited wing bending vibrations provides a powerful method for further reduction of dynamic loads and improvement of ride comfort.
A Fast Deposition‐Crystallization Procedure for Highly Efficient Lead Iodide Perovskite Thin‐Film Solar Cells (2014)

Abstract Thin‐film photovoltaics based on alkylammonium lead iodide perovskite light absorbers have recently emerged as a promising low‐cost solar energy harvesting technology. To date, the perovskite layer in these efficient solar cells has generally been fabricated by either vapor deposition or a two‐step sequential deposition process. We report that flat, uniform thin films of this material can be deposited by a one‐step, solvent‐induced, fast crystallization method involving spin‐coating of a DMF solution of CH 3 NH 3 PbI 3 followed immediately by exposure to chlorobenzene to induce crystallization. Analysis of the devices and films revealed that the perovskite films consist of large crystalline grains with sizes up to microns. Planar heterojunction solar cells constructed with these solution‐processed thin films yielded an average power conversion efficiency of 13.9±0.7 % and a steady state efficiency of 13 % under standard AM 1.5 conditions.
Cryptographically Secure Shield for Security IPs Protection (2016)

Probing attacks are serious threats on integrated circuits. Security products often include a protective layer called shield that acts like a digital fence. In this article, we demonstrate a new shield structure that is cryptographically secure. This shield is based on the lightweight block cipher and independent mesh lines to ensure the security against probing attacks of the hardware located behind the shield. Such structure can be proven secure against state-of-the-art invasive attacks. Then, we evaluate the impact of active shield on the performance of security IPs as PUF, TRNG, secure clock and AES using a set of fabricated ASICs with 65 nm CMOS technology of STMicroelectronics. Also, the impact of active shield on Side-Channel Attack (SCA) is evaluated.