gebhart/patrepeval huggingface dataset:
Paenibacillus thailandensis sp. nov. and Paenibacillus nanensis sp. nov., xylanase-producing bacteria isolated from soil (2009)

Two strains of xylanase-producing bacteria, S3-4A(T) and MX2-3(T), isolated from soils in Thailand, were characterized on the basis of their phenotypic and chemotaxonomic characteristics, DNA-DNA relatedness and 16S rRNA gene sequences. The novel strains were Gram-positive, facultatively anaerobic, spore-forming, rod-shaped bacteria. They contained meso-diaminopimelic acid as the diagnostic diamino acid in the cell-wall peptidoglycan. The DNA G+C contents of strains S3-4A(T) and MX2-3(T) were 52.7 and 52.9 mol%, respectively. The major isoprenoid quinone was MK-7. The dominant cellular fatty acids were anteiso-C(15 : 0) and iso-C(16 : 0). Phylogenetic analyses using 16S rRNA gene sequences showed that both novel strains were affiliated to the genus Paenibacillus. Strains S3-4A(T) and MX2-3(T) were closely related to Paenibacillus agaridevorans DSM 1355(T) with 97 % and 97.3 % gene sequence similarities, respectively. The DNA-DNA relatedness between strains S3-4A(T), MX2-3(T) and P. agaridevorans DSM 1355(T) was low (6.0-30.3 %). The novel strains could be clearly distinguished from P. agaridevorans DSM 1355(T) by physiological and biochemical characteristics. Therefore, these two strains represent novel species of the genus Paenibacillus, for which the names Paenibacillus thailandensis sp. nov. (type strain S3-4A(T)=KCTC 13043(T)=PCU 275(T)=TISTR 1827(T)) and Paenibacillus nanensis sp. nov. (type strain MX2-3(T)=KCTC 13044(T)=PCU 276(T)=TISTR 1828(T)) are proposed.
Surface-impedance measurements of superconducting NbN films (1991)

The temperature and frequency dependences of the surface impedance of NbN thin films have been measured from 4.2 to 13 K and from 0.5 to 10 GHz using a stripline resonator. At 4.2 K resonant-cavity measurements of surface resistance were made at 35 and 56 GHz. From surface-reactance measurements using both cavity and stripline techniques, we obtain the penetration depth extrapolated to 0 K, \ensuremath{\lambda}(0)=3700 \AA{}. For the stripline, the film thickness was approximately 8000 \AA{}, which is about two times the measured penetration depth. The weak-coupling (full) Mattis-Bardeen theory was used to fit the temperature dependence of the surface resistance. Based on the quality of the weak-coupling fit to the data, we conclude that the strong-coupling effect is not important in the local and dirty limits. We discuss the correction due to the finite film thickness of the stripline measurements of the surface resistance.
How to assess non-calcified plaque in CT angiography: delineation methods affect diagnostic accuracy of low-attenuation plaque by CT for lipid-core plaque in histology (2013)

Low-attenuation plaque in CTA is a diagnostic tool for LCP but prone to error if plaque is defined as the area between the inner and outer vessel walls and normal cross-sections are included in the assessment.
<title>Tree-structured vector quantization with input-weighted distortion measures</title> (1991)

A greedy tree-growing algorithm is used in conjunction with an input-dependent weighted distortion measure to develop a tree-structured vector quantizer. Vectors in the training set are classified, and weights are assigned to the classes. The resulting weighted distortion measure forces the tree to develop better representations for those classes that are considered important. Results on medical images and USC database images are presented. A tree-structured vector quantizer grown in a similar manner can be used for preliminary classification as well as compression.
Metabolic Phenotype and Microbiome of Infants Fed Formula Containing Lactobacillus paracasei Strain F-19 (2022)

Early childhood nutrition drives the development of the gut microbiota. In contrast to breastfeeding, feeding infant formula has been shown to impact both the gut microbiota and the serum metabolome toward a more unfavorable state. It is thought that probiotics may alter the gut microbiota and hence create a more favorable metabolic outcome. To investigate the impact of supplementation with <i>Lactobacillus paracasei</i> spp. <i>paracasei</i> strain F-19 on the intestinal microbiota and the serum metabolome, infants were fed a formula containing <i>L. paracasei</i> F19 (F19) and compared to a cohort of infants fed the same standard formula without the probiotic (SF) and a breast-fed reference group (BF). The microbiome, as well as serum metabolome, were compared amongst groups. Consumption of <i>L. paracasei</i> F19 resulted in lower community diversity of the gut microbiome relative to the SF group that made it more similar to the BF group at the end of the intervention (4 months). It also significantly increased lactobacilli and tended to increase bifidobacteria, also making it more similar to the BF group. The dominant genus in the microbiome of all infants was <i>Bifidobacterium</i> throughout the intervention, which was maintained at 12 months. Although the serum metabolome of the F19 group was more similar to the group receiving the SF than the BF group, increases in serum TCA cycle intermediates and decreases in several amino acids in the metabolome of the F19 group were observed, which resulted in a metabolome that trended toward the BF group. Overall, <i>L. paracasei</i> F19 supplementation did not override the impact of formula-feeding but did impact the microbiome and the serum metabolome in a way that may mitigate some unfavorable metabolic impacts of formula-feeding.
Symmetry-breaking-induced enhancement of visible light absorption in delafossite alloys (2009)

Through density functional theory calculations, we demonstrate that enhancement of optical absorption and optimization of the fundamental band gap for Cu delafossites can be achieved through alloying group IIIA and IIIB delafossites. These alloys significantly improved the flexibility in designing delafossite-based photoelectrodes for application in photoelectrochemical decomposition of water by visible spectra of solar light.
录像诗学:技术、美学、政治 (1998)

录像诗学：技术、美学、政治〔英国〕Ｄ．埃利夫塞里奥蒂斯赵晓力译在围绕录像展开的批判和理论话语中，技术一直是个突出而引起麻烦的范畴。本文提出一个概念框架，以期对新的视听技术进行理论分析；这个框架摆脱了技术决定论、症候技术（ｓｙｍｐｔｏｍａｔｉｃｔｅｃ...
The use of pp150 and gp116 synthetic peptides in the detection of CMV antibodies. (2010)

Background: Human cytomegalovirus (HCMV) infection may cause severe outcomes in transplant recipients and pregnant women. Diagnosis of CMV infections by using serological detection of CMV specific antibodies varies widely due to different antigen compositions in the diagnostic tests. The aim of this study was to identify the reactive peptides of CMV for CMV-IgM and –IgG detection. Methods: The reactivity of peptides (peptide 1: amino acids 595-614 of phosphoprotein 150 (pp150), peptide2: amino acides 1024-1048 of pp150, peptide3: amino acids 798-805 of C-terminal part of glycoprotein B (gp55), peptide 4: amino acids 68-81 of N-terminal part of glycoprotein B (gp 116), and peptide 5: amino acids 29-48 of glycoprotein H) as epitopes was determined in ELISA, using renal transplant recipients’ sera (n=84) with high titers of CMV-IgM and healthy individuals’ sera (n=87) with high titers of CMV-IgG antibodies. Results: Amino acids 595-614 and 1024-1048 of pp150 had a high reactivity (83.3% and 88.0%) with renal transplant recipients' sera while the other peptides did not. The amino acids 68-81 of gp116 reacted with 81.6% of the healthy individuals’ sera but the other amino acids showed low reactivity with these sera. Conclusion: Amino acids 595-614 and 1024-1048 of pp150 and amino acids 68-81 of N-terminal part of gp 116 could be considered in recombinant protein construction for detection of CMV-IgM and -IgG antibodies.
Induction of tumor promotor-inducible genes in murine 3T3 cell lines and tetradecanoyl phorbol acetate-nonproliferative 3T3 variants can occur through protein kinase C-dependent and -independent pathways. (1989)

We isolated a group of genes that are rapidly and transiently induced in 3T3 cells by tetradecanoyl phorbol acetate (TPA). These genes are called TIS genes (for TPA-inducible sequences). Epidermal growth factor (EGF), fibroblast growth factor (FGF), and TPA activated TIS gene expression with similar induction kinetics. TPA pretreatment to deplete protein kinase C activity did not abolish the subsequent induction of TIS gene expression by epidermal growth factor or fibroblast growth factor; both peptide mitogens can activate TIS genes through a protein kinase C-independent pathway(s). We also analyzed TIS gene expression in three TPA-nonproliferative variants (3T3-TNR2, 3T3-TNR9, and A31T6E12A). The results indicate that (i) modulation of a TPA-responsive sodium-potassium-chloride transport system is not necessary for TIS gene induction either by TPA or by other mitogens and (ii) TIS gene induction is not sufficient to guarantee a proliferative response to mitogenic stimulation.
Modification of Si(100) Substrate Bonding by Adsorbed Ge or Si Dimer Islands (1998)

High-resolution scanning tunneling microscopy studies of the $\mathrm{Si}(100)\ensuremath{-}(2\ifmmode\times\else\texttimes\fi{}1)$ surface show a heretofore unrecognized distortion of the substrate structure when islands form during the initial stage of growth of either Si or Ge. The distortion, reflecting the influence of strain, extends at least three dimers away from the adsorption sites. We present a realistic structural model.
Scalar model of flocking dynamics on complex social networks (2019)

We investigate the effects of long-range social interactions in flocking dynamics by studying the dynamics of a scalar model of collective motion embedded in a complex network representing a pattern of social interactions, as observed in several social species. In this scalar model we find a phenomenology analogous to that observed in the classic Vicsek model: In networks with low heterogeneity, a phase transition separates an ordered from a disordered phase. At high levels of heterogeneity, instead, the transition is suppressed, and the system is always ordered. This observation is backed up analytically by the solution of a modified scalar model within an heterogeneous mean-field approximation. Our work extends the understanding of the effects of social interactions in flocking dynamics and opens the path to the analytical study of more complex topologies of social ties.
ChemInform Abstract: Sequential Biocatalytic Aldol Reactions in Multistep Asymmetric Synthesis: Pipecolic Acid, Piperidine and Pyrrolidine (Homo)Iminocyclitol Derivatives from Achiral Building Blocks. (2015)

Abstract Two consecutive enzymatic and asymmetric aldol reactions allow the synthesis of stereodefined pipecolic acid (I), piperidine, and pyrrolidine (homo)iminocyclitol [(II) and (III)] derivatives from dimethoxy acetaldehyde and glycine.
ResIn (2008)

Results caching is an efficient technique for reducing the query processing load, hence it is commonly used in real search engines. This technique, however, bounds the maximum hit rate due to the large fraction of singleton queries, which is an important limitation. In this paper we propose ResIn - an architecture that uses a combination of results caching and index pruning to overcome this limitation.
SrTiO3-based varactors for Ka-band application: Preparation and properties (2000)

SrTiO3(STO)-based varactors with YBa2Cu3O7Οx (YBCO) electrodes were pulsed laser deposited on MgO substrate by using intermediate oxygen relaxation technique, i.e. the STO film was deposited in sequence of four 100nm thick layers with intermediate cooling in oxygen down to 300 °C. The oxygen treatment as well as introducing of a homoepitaxial MgO layer in between the MgO substrate and STO film, reduced the residual strain in the STO film and improved microwave properties of the varactors. Typical parameters of the varactors measured at 77K in a frequency range: 25 - 50 GHz were: capacitance, C, 30-40 fF, tuning C(0V)/C(40V) of 1.2, Q-factor of 20-40 and leakage current less than 0.25 nA, when a DC bias of 40V was applied. These results show applicability of the fabricated varactors at Ka band and higher frequencies.
Human PUM1 and PUM2 exhibit regulation of divergent mRNA targets in male germ cells (2019)

ABSTRACT Mammalian Pumilio (PUM) proteins are sequence-specific, RNA-binding proteins with wide-ranging roles, including germ cell development that has functional implications in fertility. Although human PUM1 and PUM2 are closely related to each other and recognize the same RNA binding motif, there is some evidence for functional diversity, particularly related to their roles in fertility. Here, by RNA sequencing (RNA-Seq) approaches, we identified separate mRNA pools regulated by PUM1 and PUM2 proteins in human male germ cells. Using global mass spectrometry-based profiling, we identified distinct PUM1- and PUM2-bound putative protein cofactors, most of them involved in RNA processing. Combinatorial analysis of RNA-Seq and mass spectrometry findings revealed that PUM1 and PUM2 may form distinct RNA-regulatory networks, with different roles in human reproduction and testicular tumorigenesis. Our findings highlight the functional divergence and versatility of PUM paralogue-based post-transcriptional regulation, offering insight into the mechanisms underlying their diverse biological roles and diseases resulting from their dysfunction.
Characterization of Dedifferentiating Human Mature Adipocytes from the Visceral and Subcutaneous Fat Compartments: Fibroblast-Activation Protein Alpha and Dipeptidyl Peptidase 4 as Major Components of Matrix Remodeling (2015)

Mature adipocytes can reverse their phenotype to become fibroblast-like cells. This is achieved by ceiling culture and the resulting cells, called dedifferentiated fat (DFAT) cells, are multipotent. Beyond the potential value of these cells for regenerative medicine, the dedifferentiation process itself raises many questions about cellular plasticity and the pathways implicated in cell behavior. This work has been performed with the objective of obtaining new information on adipocyte dedifferentiation, especially pertaining to new targets that may be involved in cellular fate changes. To do so, omental and subcutaneous mature adipocytes sampled from severely obese subjects have been dedifferentiated by ceiling culture. An experimental design with various time points along the dedifferentiation process has been utilized to better understand this process. Cell size, gene and protein expression as well as cytokine secretion were investigated. Il-6, IL-8, SerpinE1 and VEGF secretion were increased during dedifferentiation, whereas MIF-1 secretion was transiently increased. A marked decrease in expression of mature adipocyte transcripts (PPARγ2, C/EBPα, LPL and Adiponectin) was detected early in the process. In addition, some matrix remodeling transcripts (FAP, DPP4, MMP1 and TGFβ1) were rapidly and strongly up-regulated. FAP and DPP4 proteins were simultaneously induced in dedifferentiating mature adipocytes supporting a potential role for these enzymes in adipose tissue remodeling and cell plasticity.
A phase I/II study of the safety and anti-cancer activity of IV-administered belinostat (PXD101) plus carboplatin (C) or paclitaxel (P), or both in patients with advanced solid tumors (2007)

3574 Background: Belinostat (PXD101), a HDAC inhibitor of the hydroxamate class has shown anti-tumor preclinical activity in combination with other standard chemotherapeutic agents. In Ph. I and II clinical trials the MTD for belinostat has been established at 1,000 mg/m 2 /d. This Ph I/II study assesses safety, and anti-cancer activity of belinostat administered in combination with C and/or P. Methods: Sequential cohorts of 3–6 patients (pts) with advanced solid tumors and PS 0–2 were recruited to determine the MTD of standard dose C and/or P with escalating doses of belinostat administered as a 30-min IV infusion daily for 5 days (d) every 21 d. C and/or P were administered 2–3 hours following infusion of belinostat on d 3. Results: 23 pts have been treated with a mean of 5 cycles (range 1 - 15) at 5 dose levels: C and belinostat (600 mg/m 2 ) (5 pts); P and belinostat (600 mg/m 2 ) (5 pts); C and P and belinostat (600 mg/m 2 ) (3 pts); C and P and belinostat (800 mg/m 2 ) (4 pts); C and P and belinostat (1,000 mg/m 2 ) (6 pts). Possibly drug-related grade 3 or 4 toxicities were thrombocytopenia (2), vomiting (1), sensory neuropathy (1), myalgia (1), and fatigue (1).No DLT was observed. One SAE (grade 1 T-wave morphology change) was graded as possibly drug-related. No QTcf greater than 500ms were reported. There are 2 confirmed PRs: 1 with heavily treated metastatic rectal cancer and 1 with gemcitabine pre-treated metastatic pancreatic cancer. An additional 11[E1] patients had SD for 2–15 cycles, with 4 being SD for &gt;10 cycles. One pt with mixed mullerian cancer of ovarian origin with SD had an 81% reduction in CA-125 to normal levels after 6 cycles. [E1]If you include MMMT pt as SD on radio. Conclusions: Belinostat with standard dose C and/or P is well-tolerated and shows clinical activity in heavily pre-treated patients with advanced metastatic disease. Recruitment to a phase II expansion in pts with recurrent ovarian cancer is ongoing. No significant financial relationships to disclose.
Picotamide inhibition of excess in vitro thromboxane B2 release by colorectal mucosa in inflammatory bowel disease. (1996)

Since increased thromboxane A2 production may have pathogenetic importance, thromboxane synthesis inhibitor-receptor antagonists such as picotamide merit therapeutic trial in the management of inflammatory bowel disease.
Host-guest interaction between Acridine orange molecules and AFI or CHA zeolite crystals (2017)

Acridine orange (AO) molecules were incorporated in AlPO<sub>4</sub>-5, SAPO-5 and SAPO-47 single crystals by vapor-phase diffusion method. Polarized absorption spectra show that AO molecules are well aligned by the one-dimensional channel systems of AlPO<sub>4</sub>-5 and SAPO-5 matrices. While the orientation of AO molecules in SAPO-47 crystals is diverse owing to the three-dimensional cage structure of chabazite (structure code CHA). The absorption peak and emission peak of AO/SAPO-5 blue shift compared with that of AO/AlPO<sub>4</sub>-5 because the channel environment changes from non-polar medium to polar medium when Si substituted in the framework of AlPO<sub>4</sub>-5. The greater blue shift in absorption band and emission band of AO/SAPO-47 are expected to originate from the polar channel medium and smaller channel size of SAPO-47.
In utero Allogeneic Hematopoietic Stem Cell Transplantation to Induce Tolerance (1996)

We studied the efficacy of in utero hematopoietic stem cell transplantation and the ability of such transplantation to induce tolerance in a fetal normal mouse allogeneic model. In 9 of the 162 surviving recipients (5.6%), cells of donor origin were detected after birth. The highest engraftment rate was achieved by transplanting fetal liver cells in a relatively high dose (> 10(6) cells/fetal gram). Skin grafting was performed to determine the presence of prenatally induced tolerance. Only those mice which showed evidence of chimerism became tolerant to skin derived from the prenatal donor's strain while remaining competent to reject a skin transplant from a third strain. Tolerant mice could have significant chimerism reestablished by utilizing monoclonal antibody specific for the recipient H-2 antigen as conditioning for IV fetal stem cell retransplantation.
Fatty Acids and Esters as Antimicrobial/Insecticidal Agents (1987)

Structure-function relationships of fatty acids and monoesters are reviewed. Many of the generalistics found concerning chain length, unsaturation, esterification and geometrical isomerism hold whether germicidal or insecticidal properties are being considered. Saturated fatty acids reach their optimal effects with chains 12 carbons long. Monounsaturation increases the activity of long (C14 or greater) but not short (<C12) chain fatty acids. Cis unsaturated fatty acids are more active than trans acids. Adding a second double bond further increases activity while the addition of a third double bond does not substantially improve activity. Esterification to monohydric alcohol causes deactivation of the fatty acid while esterification to polyhydric compounds (glycerol, polyglycerol, sucrose, etc.) generally leads to a more active derivative. While the potency of these lipid derivatives are not as strong as many current germicides/insecticides, they offer greater safety in their application. For the most part, these chemicals are approved in food applications. Because of this safety factor, these lipids need to be further exploited.
Colorimetric Measurement of Angiotensin I-Converting Enzyme Inhibitory Activity with Trinitrobenzene Sulfonate (1992)

Journal Article Colorimetric Measurement of Angiotensin I-Converting Enzyme Inhibitory Activity with Trinitrobenzene Sulfonate Get access Toshiro Matsui, Toshiro Matsui Department of Food Science and Technology, Faculty of Agriculture, Kyushu University, 6–10–1 Hakozaki, Higashi-ku, Fukuoka 812, Japan Corresponding author. Search for other works by this author on: Oxford Academic Google Scholar Hiroshi Matsufuji, Hiroshi Matsufuji Department of Food Science and Technology, Faculty of Agriculture, Kyushu University, 6–10–1 Hakozaki, Higashi-ku, Fukuoka 812, Japan Search for other works by this author on: Oxford Academic Google Scholar Yutaka Osajima Yutaka Osajima Department of Food Science and Technology, Faculty of Agriculture, Kyushu University, 6–10–1 Hakozaki, Higashi-ku, Fukuoka 812, Japan Search for other works by this author on: Oxford Academic Google Scholar Bioscience, Biotechnology, and Biochemistry, Volume 56, Issue 3, 1 January 1992, Pages 517–518, https://doi.org/10.1271/bbb.56.517 Published: 01 January 1992 Article history Received: 26 August 1991 Published: 01 January 1992
Early salivary changes in multiple myeloma patients undergoing autologous HSCT (2018)

Compositional changes in saliva reflecting inflammation were found in the first days after HSCT, and the use of cryotherapy in the second part was associated with decreased OM severity.
Insulin-like Growth Factor 1 Induces Hypoxia-inducible Factor 1-mediated Vascular Endothelial Growth Factor Expression, Which is Dependent on MAP Kinase and Phosphatidylinositol 3-Kinase Signaling in Colon Cancer Cells (2002)

Stimulation of human colon cancer cells with insulin-like growth factor 1 (IGF-1) induces expression of the VEGF gene, encoding vascular endothelial growth factor. In this article we demonstrate that exposure of HCT116 human colon carcinoma cells to IGF-1 induces the expression of HIF-1 alpha, the regulated subunit of hypoxia-inducible factor 1, a known transactivator of the VEGF gene. In contrast to hypoxia, which induces HIF-1 alpha expression by inhibiting its ubiquitination and degradation, IGF-1 did not inhibit these processes, indicating an effect on HIF-1 alpha protein synthesis. IGF-1 stimulation of HIF-1 alpha protein and VEGF mRNA expression was inhibited by treating cells with inhibitors of phosphatidylinositol 3-kinase and MAP kinase signaling pathways. These inhibitors also blocked the IGF-1-induced phosphorylation of the translational regulatory proteins 4E-BP1, p70 S6 kinase, and eIF-4E, thus providing a mechanism for the modulation of HIF-1 alpha protein synthesis. Forced expression of a constitutively active form of the MAP kinase kinase, MEK2, was sufficient to induce HIF-1 alpha protein and VEGF mRNA expression. Involvement of the MAP kinase pathway represents a novel mechanism for the induction of HIF-1 alpha protein expression in human cancer cells.