gebhart/patrepeval huggingface dataset:
Food cravings, appetite, and snack-food consumption in response to a psychomotor stimulant drug: the moderating effect of â€œfood-addictionâ€ (2014)

There is mounting evidence that many highly processed foods have addictive properties, and that some cases of compulsive overeating resemble an addiction disorder. While support for the Yale Food Addiction Scale (YFAS) as a valid diagnostic tool has been impressive and continues to increase, to date, no research has examined the food-addiction construct in response to an actual food stimulus, and in relation to direct measures of appetite and food consumption. As part of a larger community-based study of overeating in healthy adults who were predominately overweight and obese (aged 25-50 years), 136 participants completed the YFAS, of whom 23 met the diagnostic criteria for food-addiction. They took part in a 2-day, double-blind, cross-over, single-dose drug challenge using a psychomotor stimulant (methylphenidate) and placebo. Participants were first assessed on ratings of appetite and food cravings after holding and tasting their favorite snack food, after which they were able to eat all or part of the snack, as they wished. Three separate repeated-measures analysis-of-variance procedures were carried out, each with two between-subjects factors (Diagnosis: food-addiction vs. non-food addiction) and (Sex: male vs. female) and 1 within-subjects factor (Days: drug vs. placebo). As anticipated, for all three dependent variables, there was a significant main effect for Days with a response decrease from placebo to the drug condition. With respect to food cravings and appetite ratings, results indicated that the food addiction group had significantly higher scores on both variables. For food consumption, there was a significant Days × Diagnosis interaction whereby the food-addiction group showed no food-intake suppression across days compared to the non-food-addiction group who demonstrated a significant decrease in snack-food consumption with methylphenidate. The finding that the food-addiction group was resistant to the food-intake suppression typically induced by a dopamine agonist supports evidence of dopamine signaling-strength differences in individuals with compulsive overeating compared to those without this disorder. This represents the first demonstration that individuals defined by their food-addiction status have a unique pattern of food-intake following a pharmacologic challenge with such agents.
Characteristics of pure-titanium and low carbon steel friction-welded joint with post-weld heat-treatment (2016)

The characteristics of friction-welded joint between commercially pure-titanium (CP-Ti) and low carbon steel, of which was subjected to post-weld heat-treatment (PWHT), was investigated. When the joint was made with friction speed of 25 s −1 , friction pressure of 200 MPa, friction time of 2.5 s and forge pressure of 250 MPa, it had the same tensile strength as that of the CP-Ti base metal. The joint had no intermediate layer consisting of intermetallic compound (IMC interlayer) at the weld interface. The joint efficiency of the joint subjected to PWHT decreased with increasing heating temperature and its holding time, and the joint fractured at the weld interface although it had no IMC interlayer. The void was generated on the weld interface of the joint during PWHT process.
A test of a common elements theory of transfer (1986)

All discussions of interface design criteria emphasize the importance of consistent operating procedures both within and across applications. This paper presents a model for positive transfer and thus a theoretical definition of consistency. An experiment manipulating training orders for utility tasks was designed to evaluate the transfer model. The experimental manipulations produced large transfer effects. Quantitative predictions were derived from the Kieras and Polson (1985) theory of human-computer interaction and the transfer model and fit using regression techniques. The transfer model accounted for 88% of the variance of the 31 cell means.
T- Cell Depleted Peripheral Blood Stem Cell (TCD-PBSC) Transplants Secure Consistent Engraftment with Low Risk of Acute or Chronic Gvhd and Favorable Disease Free Survival (DFS) and Overall Survival (OS) for Pediatric Patients (<21 years) with AML in CR1 (2016)

Higher cGVHD, TRM and treatment failure following sib donor unmanipulated allo PBSCT compared to BMT in children and adolescents has been reported by the IBMTR (Eapen M et al, J Clin Oncol, 2004). To determine the effect of TCD of PBSC on outcome for pediatric pts with AML or MDS, we reviewed results with 49 patients (pts) with AML-1CR(n=18), AML-CR2(n=11), MDS(n=10) and tAML/MDS(n=8/2) following allo TCD-PBSCT transplanted between 6/2003 and 1/2015. Median age was 13.9yrs (range 1.9 – 20.4) with 27 males and 19pts CMV seropositive. Donors were related HLA identical (14 sibs, 1 uncle), unrelated HLA 10/10 (n=14) or unrelated HLA mismatched (n=20: 9/10 n=12: 8/10 n=8). Cytoreduction consisted of a HFTBI (n=14) with thio/ctx (n=12) or thio/flu (n=2). 35 pts had chemotherapy alone: BU/MEL/FLU (n=31) or other (n=4). ATG provided graft rejection prophylaxis for 43 pts either pre (n=37) or post (n=6) infusion. Six young pts with sib donors did not receive ATG. No pt received additional GVHD prophylaxis. PBSC were CD34+ selected with ISOLEX 300i Magnetic Cell Selection System, followed by sheep erythrocyte r (n=25) or with Miltenyi CliniMACS device (n=24). The median CD34+ cells/Kg was 10.5x106 (range 3.3 – 33.4x106) and CD3+ cells/kg was 2.4x103 (range 0 – 29x103). All pts engrafted neutrophils and platelets at a median of 11 days (range 9 – 14) and 26 days (range 13 – 182), respectively. 42pts had platelet recovery by day 40. One pt who had late graft failure (GF) at 3.5 mos engrafted with a subsequent unmanipulated PBSCT. 7 pts developed Grade II or III aGVHD of skin or GI. No pt had Gr IV aGVHD. 6 pts responded to treatment. Only 1pt developed limited cGVHD of the skin. No pt who was CMV seronegative developed CMV viremia. 7 of 19 CMV seropositive pts developed CMV viremia. 9 pts received rituximab for EBV viremia.Tabled 1N1oGF2oGFaGVHD (Gr 2-3)cGVHD (limited)CMV-CTLEBV-CTLRelapseAlive in CR p2nd SCT for GF/rel3 yrs DFS3 yr OSEntire Cohort4901(2%)6(12%)1(2%)1(2%)1(2%)11(22%)5 (4rel,1GF)72.3%87.7%AML-CR11800210043 (3rel)75.6%94.4AML-CR2110020114056.0%66.7MDS1001000022 (1GF,1rel)78.8%100%tAML/MDS100020001080.0%88.9% Open table in a new tab With a median follow-up of 36.3 mos the DFS and OS at 3 yrs is 72.3% and 87.7%, respectively. Although the DFS for pts with AML-CR1 is 75.6%, 3 of 4 pts are in CR2 post a 2nd SCT for OS of 94.4%. The 4 pts with AML-CR2 who relapsed died of disease. 8 of 49 pts died (6pts w disease; 1 pt w aGVHD and 1 pt (Down Syndrome) w MOF (VOD). Thus, in young pts (< 21 yrs) TCD-PBSCT is associated with low risk of GVHD, no increment in relapse and a highly favorable DFS and OS. The data support the inclusion of pediatric pts with AML/MDS in BMT CTN 1301 trial (NCT02345850).
The protracted effect of o,p'-DDD in Cushing's disease and its impact on adrenal morphogenesis of young human embryo. (1989)

We hereby present a patient with Cushing's disease who became pregnant while being treated with o,p'-DDD and underwent a therapeutic abortion in view of the known embryotoxicity and placental transfer of this drug. Biopsy of adipose tissue in this patient showed it to be the storage site of considerable quantities of o,p'-DDD. Serum levels of o,p'-DDD determined in this patient initially four months after withdrawal of treatment and in another similar case three months after withdrawal were about 20 times higher than those found in untreated patients and reached control values only about 20 months later. Repeated evaluation of plasma and urinary free cortisol failed to reveal any correlation with the serum levels of o,p'-DDD, suggesting that the drug blood values cannot be used as a reliable indicator of the therapeutic effect on the adrenal gland. The histopathological examination of the embryo, aged about 42 days, revealed a dysmorphogenic event in the cortical primordia characterized by pycnotic sympathoblasts. It is suggested that such a toxic effect of o,p'-DDD on the embryonic cortical cells may act indirectly, affecting the viability of the migrating sympathoblasts.
30 Gbit/s RZ-8-PSK Transmission over 2800 km Standard Single Mode Fibre without Inline Dispersion Compensation (2008)

For the first time, 30-Gbit/s-RZ-8-PSK (including FEC overhead) transmission over 2800 km standard single mode fibre without inline compensation of chromatic dispersion is experimentally demonstrated using homodyne detection, carrier phase estimation and electronic dispersion compensation.
Effects of pulsed ultrasound and ultraviolet radiation on Vitamin E and olive oil (1994)

Synopsis The effects of ultrasound and ultraviolet radiation on Vitamin E and its pharmacological excipient, olive oil, were tested by fluorescent analysis of DNA unwinding (FADU) on DNA extracted from human lymphocytes of healthy donors. The results show that Vitamin E may be inactivated and behave as a radical species, while olive oil appears unaffected by treatment either with ultrasound or with ultraviolet radiation.
Wideband channel model for aeronautical telemetry (2004)

A multipath channel model for wideband aeronautical telemetry links is presented. Channel sounding data were collected at Edwards AFB, CA, at both L-band and lower S-band. Frequency domain analysis techniques were used to evaluate candidate channel models. The channel model is composed of three propagation paths: a line-of-sight direct path and two specular reflections. The first specular reflection is characterized by a relative amplitude of 70% to 96% of the line-of-sight amplitude and a delay of 10-80 ns. This path is the result of "ground bounces" off the dry lake bed at Edwards and is a typical terrain feature at DoD test ranges located in the western United States. The amplitude and delay of this path are defined completely by the flight path geometry. The second path has much lower amplitude and a longer delay. The gain of this path is well modeled as a zero-mean complex Gaussian random variable. The relative amplitude is approximately 2% to 8% of the line-of-sight amplitude. The mean excess delay is 155 ns with an rms delay spread of 74 ns.
Respiratory Drug Delivery (2006)

In respiratory drug delivery the lungs or the nose are exploited as absorption sites for the administration of systemically-acting drugs. Inhalation dosage forms allow to introduce the formulation inside the airways by generating a respirable aerosol. These dosage forms are unique since together the formulation and delivery device constitute the inhalation product, both affecting the bioavailability of the inhaled drug.&#13;\nThe biopharmaceutical constraints of orally administered drug products can be less stringent for preparations for inhalation, which introduce though other issues, i.e., delivery and lung deposition. Deposition anticipates the dissolution and permeation processes and depends on the formulation and the device that must guarantee that the right amount of drug is delivered and inhaled.&#13;\nThe main quality requirement of an inhalation product is its respirability, determined by the capacity of the drug formulation to be aerosolized, inhaled and deposited into the lung. This depends essentially on the aerodynamic diameter of the particle or droplet composing the aerosol.&#13;\nHere, the main types of pulmonary inhalers are illustrated, focusing on the aerodynamic behavior of the generated aerosol. Much attention is given to metered dose inhalers (MDIs) and their recent change of propellants and on dry powder inhalers (DPI) with their advanced solution for dosing and aerosolizing fine powders for systemic drug delivery. Finally, nasal drug delivery is considered with respect to the variables affecting the efficiency of the administration.
Switched-mode power supplies in practice (1989)

Introduction and Selection of Different Types of Converters. Induction--Coupled Step--Down Converters (Forward Converters). Flyback Converters. Inductor--Coupled Step--Up Converter. Single--Ended Forward Converter for Mains Input. Push--Pull and Bridge Converters for Mains Operation. Flyback Converters for Mains Operation. Integrated Control Circuits. Interference Suppression and Protection Circuits. References. Index.
Calculation of Nuclear Magnetic Shielding Constants in Two Simple Systems (1967)

The nuclear magnetic shielding constants of two simple systems are calculated explicitly. These systems are (1) a nucleus μ at a distance R from a hydrogenic atom of charge ζe in the presence of an external electric field, and (2) a nucleus μ of a hydrogenic atom of charge ζe in the presence of a point charge at R with the result expanded in inverse powers of R. These calculations should prove useful in understanding the long-range contributions of functional groups and neighboring molecules to observed chemical shifts of molecules.
Plasma deposited thin films (1986)

This book presents a discussion of the mechanisms and practice of plasma deposition with particular emphasis on significant materials produced by this technique, and their applications. Materials discussed include hydrogenated amorphous silicon and its alloys, amorphous carbon, and the critically important insulators such as silicon nitride, carbide, and oxide. In addition, a review is given, with extensive references, of many other potentially useful materials. A major theme of this book is the interrelationship between the process, the authors' understanding of the properties of materials, together with device fabrication and ultimate performance. Over 150 figures complement the text.
Transfert et métabolisme de l'azote et du phosphore dans l'hydrosystème Seine (1996)

info:eu-repo/semantics/published
Photonic Paints: Structural Pigments Combined with Water‐Based Polymeric Film‐Formers for Structurally Colored Coatings (2019)

Abstract Paints contain at least two components: a colorant and a polymeric binder, dispersed in a fluid medium. The first imparts color to the paint coating, while the second encapsulates the colorant upon drying in a robust polymeric film adherent to the surface substrate. Photonic pigments, inspired by nature's coloration strategy, hold promise as a replacement for toxic and fade‐prone absorptive colorants, most prominently in the fabrication of stable and sustainable water‐based paints. Crucially however, the step to combine photonic pigments with polymeric binders has not yet been taken. Here, a water‐based paint is designed and realized containing both photonic pigments synthesized by a scalable emulsion process and commercial polymeric binders in an aqueous dispersion. The photonic pigments are silica spheres containing a close‐packed array of air pores, of which both the periodicity and degree of long‐range ordering can be controlled to produce pigments of varying colors and degrees of iridescence. The readiness of the photonic paints for application is demonstrated by applying them like traditional paints in homages of famous artistic paintings. These findings should stimulate widespread application of structural pigments as colorants in not only paints but also a variety of industrially important materials, such as plastics, inks, or cosmetics.
Thrombin as a Multifunctional Protein: Induction of Cell Adhesion and Proliferation (1992)

The serine protease thrombin (E.C.3.4.21.5) is well recognized for its central role in hemostasis. In addition, thrombin is unique among the enzymes participating in the clotting cascade, by virtue of its cell activation effects induced via the enzymatic pocket or via functional domains located throughout the molecule. In this review, we elaborate on "nonhemostatic" activities of thrombin among which are interactions with vessel wall components. These activities include promotion of cellular adhesion and induction of smooth muscle cell proliferation. Thrombin can exert these effects when it is in a fluid phase and when it is immobilized to extracellular matrix.
Enhanced Photocatalytic Activity of Iron-Doped ZnO Nanowires for Water Purification (2017)

In order to improve the photocatalytic efficiency of ZnO nanowires, iron-doped ZnO nanowires (ZnO:Fe NWs) were successfully synthesized. The morphology, optical properties and photocatalytic performance of ZnO:Fe NWs were studied by scanning electron microscopy (SEM), UV-Visible spectrophotometry and photoluminescence spectroscopy (PL), respectively. The SEM observations showed that the morphology of the ZnO NWs was not modified by iron doping, but the band gap was reduced from 3.29 eV for ZnO NWs to 3.25 eV for ZnO:Fe NWs. This band gap reduction allows the semiconductor to harvest more photons to excite more electrons in the valence band; subsequently, resulting in an improvement of the degradability of the understudied organic dyes: methylene blue (MB), methyl orange (MO), and acid red 14 (AR14). The photocatalytic study showed that the photo-degradation rate of the MB, MO, and AR14 was improved 9%, 20%, and 5% respectively by 1% iron doping in the ZnO NWs.
Methods for the Evaluation of Image Quality: A Review (2000)

Journal Article Methods for the Evaluation of Image Quality: A Review Get access L.G. Månsson L.G. Månsson Search for other works by this author on: Oxford Academic PubMed Google Scholar Radiation Protection Dosimetry, Volume 90, Issue 1-2, 1 August 2000, Pages 89–99, https://doi.org/10.1093/oxfordjournals.rpd.a033149 Published: 01 August 2000
Diagnostic Evaluation of Exhaust Gas Recirculation (EGR) System on Gasoline Electric Hybrid Vehicle (2020)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;Diagnosing the Exhaust Gas Recirculation (EGR) Valve remains one of the most challenging problems in emissions control systems diagnostics. California Air Resources Board (CARB) has started imposing specific requirements on automotive companies since 2011 that required the integration of on-board diagnostics (OBD) monitor for the detection and reporting of this type of control malfunction. In this paper, some methodologies of EGR valve system monitoring are investigated and a novel approach is proposed that shows reliable detection capability compared to the other methods. The proposed method requires certain conditions during deceleration fuel shutoff events to intrusively reactivate the EGR system and determine the obstructed valve condition. The method was evaluated on a 2.5L iVCT engine in an experimental Ford Escape Full Hybrid Electric vehicle. Vehicle results are shown and discussed.&lt;/div&gt;&lt;/div&gt;
“Beyond HDTV” [Scanning the Issue] (2012)

Provides an overview of the technical articles and features presented in this issue.
IMIPRAMINE‐INDUCED CHANGES OF BRAIN ADENOSINE TRIPHOSPHATASE ACTIVITY (1973)

Abstract— Adenosine triphosphatase (ATPase) activities of brain microsomal and synaptosomal preparations are inhibited by imipramine [5‐(3′‐dimethylamino propyl)‐10, 11‐dihy‐dro‐5H‐dibenz (b,f) azepine] in vitro , whereas microsomal ATPase activity is stimulated and synaptosomal ATPase activity remains unaltered under in vivo imipramine treatment. The inhibition of ATPase activity can to some extent be counteracted by spermine [N, N′‐bis(3 aminopropyl)‐1,4‐butanediamine]. Determination of K m values from double reciprocal plots (activity ‐1 vs. ATP mM ‐1 ) under drug and spermine‐treated conditions appear to indicate that spermine can to some extent imparta stabilizing effect mainly on the microsomal membrane ATPase, preventing inhibition in presence of imipramine in vitro , although spermine has no effect on the already destabilized membrane ATPase. Spermine exerts a stabilizing effect on membrane ATPase possibly by increasing the affinity of the enzyme for the substrate.
Proteolytic dissection of Sindbis virus core protein (1990)

Mild trypsin treatment of the Sindbis virus nucleocapsid protein yields a fragment with a molecular mass of approximately 18.5 kilodaltons with its N terminus at residue 105. The fragment, which is stable to further digestion, appears by gel exclusion chromatography to be monomeric. These data are consistent with a model for the alphavirus core proteins, consisting of an extended and flexible N-terminal arm (residues 1 to 103) and a compactly folded C-terminal domain (residues 104 to 274), as previously suggested on the basis of sequence characteristics.
The Design of High-Resolution Digital Filters (1966)

Seismic recordings made with standard filters often afford insufficient resolution for overlapping reflected events. In this treatment we apply least squares Wiener theory to the design of high-resolution digital time-domain filters. Under the assumption that estimates of the seismic pulse shape are available, we present techniques that allow one to calculate digital filters which transform this pulse into one which is sufficiently sharp so that it can be distinguished against a background of noise. The two design criteria governing filter performance are filter lag and filter memory function duration. The performance of a Wiener filter is numerically measurable by a quantity which we call the filter performance parameter P, where 0 P 1. The quality of the filter output improves as P approaches unity. We thus seek that combination of lag and memory function duration that maximizes P. This goal can be accomplished by the study of a two-dimensional display of P vs. lag and memory function duration. The proposed design techniques are illustrated by means of numerical examples.
Anti-obesity and fatty liver-preventing activities of Lonicera�caerulea in high-fat diet-fed mice (2018)

Blue honeysuckle (BH, Lonicera caerulea) is used as a traditional medicine in Russia, Japan and China, but is not commonly considered as an edible berry in Europe, USA or Korea. BH has been revealed to decrease serum cholesterol and triacylglycerol (triglyceride or TG) levels through the activation of AMP‑activated protein kinase (AMPK), thus it is expected to be a health functional food and pharmaceutical agent for the prevention of non‑alcoholic liver damage, in addition to effects as a suppressor of hyperlipidemia and as an anti‑obesity agent. In the present study, the pharmacological activity of BH extract (BHe) was observed in high‑fat diet (HFD)‑fed mice. Significant increases in fat pad weight, body weight, fat accumulation (body and abdominal fat density, and thickness of the periovarian and abdominal wall) and serum biochemical levels (aspartate transaminase, alanine aminotransferase, alkaline phosphatase, lactate dehydrogenase, γ‑glutamyltransferase, total cholesterol, low‑density lipoprotein and TG, with the exception of high‑density lipoprotein) were observed in HFD‑fed mice. In addition, increases in adipocyte hypertrophy, the area of steatohepatitis and hepatocyte hypertrophy were observed, whereas decreased zymogen content was identified upon histopathological observation. Increased deterioration of the endogenous antioxidant defense system (liver catalase, glutathione and superoxide dismutase) and hepatic lipid peroxidation was observed. In addition, there were decreases in hepatic glucokinase activity, AMPKα1 and AMPKα2 mRNA expression, adipose tissue uncoupling protein 2 expression, and adiponectin mRNA expression, increases in phosphoenolpyruvate carboxykinase and glucose‑6‑phosphatase activity, hepatic acetyl‑CoA carboxylase 1 mRNA expression, and the expression of leptin, CCAAT/enhancer‑binding protein (C/EBP) α, C/EBPβ and sterol‑regulatory‑element‑binding protein 1c mRNA in the periovarian tissue. Furthermore, non‑alcoholic fatty liver disease (NAFLD) and obesity were significantly inhibited by the continuous administration of BHe for 84 days. These results revealed that BHe may be a promising novel drug or functional food candidate for the treatment of obesity and NAFLD.