gebhart/patrepeval huggingface dataset:
A model-based Bayesian framework for ECG beat segmentation (2009)

The study of electrocardiogram (ECG) waveform amplitudes, timings and patterns has been the subject of intense research, for it provides a deep insight into the diagnostic features of the heart's functionality. In some recent works, a Bayesian filtering paradigm has been proposed for denoising and compression of ECG signals. In this paper, it is shown that this framework may be effectively used for ECG beat segmentation and extraction of fiducial points. Analytic expressions for the determination of points and intervals are derived and evaluated on various real ECG signals. Simulation results show that the method can contribute to and enhance the clinical ECG beat segmentation performance.
Liquid-vapor equilibria at 760 mmHg in the systems methanol-acetonitrile and acetonitrile-propyl bromide (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLiquid-vapor equilibria at 760 mmHg in the systems methanol-acetonitrile and acetonitrile-propyl bromideAbraham Tamir and Jaime WisniakCite this: J. Chem. Eng. Data 1986, 31, 3, 363–364Publication Date (Print):July 1, 1986Publication History Published online1 May 2002Published inissue 1 July 1986https://pubs.acs.org/doi/10.1021/je00045a030https://doi.org/10.1021/je00045a030research-articleACS PublicationsRequest reuse permissionsArticle Views107Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Mycobacteraemia among HIV-1-infected patients in São Paulo, Brazil: 1995 to 1998 (2004)

From July 1995 to August 1998, mycobacterial blood cultures were obtained from 1032 HIV-infected patients seen at the Centro de Referência e Treinamento de AIDS (CRTA), Hospital São Paulo (HSP), and Centro de Referência de AIDS de Santos (CRAS). Overall, 179 episodes of mycobacteraemia were detected: 111 (62.0%) at CRTA, 50 (27.9%) at HSP, and 18 (10.1%) at CRAS. The frequency of positive cultures declined sharply from 22.6% in 1995 to 6.9% in 1998, consistent with the decrease in opportunistic infections following the publicly funded distribution of highly active antiretroviral therapy. In 1995, mycobacteraemia was more frequently due to Mycobacterium avium complex (59.2%) than Mycobacterium tuberculosis (28.6%), whereas in 1998 the relative frequencies were reversed (28.6 vs. 64.3% respectively), probably justified by the increased virulence of M. tuberculosis and the greater risk of invasive infection in less-immunocompromised patients, including patients unaware they are infected with HIV.
PpSP44 nucleotide and amino acid variation. (2020)

&lt;p&gt;(A) Weblogo illustrating the relative frequencies of nucleotide polymorphisms in wild caught &lt;i&gt;P&lt;/i&gt;. &lt;i&gt;papatasi&lt;/i&gt; populations from PPAW, PPJM, and PPJS. (B) Weblogo illustrating the relative frequencies of amino acid polymorphisms in wild caught &lt;i&gt;P&lt;/i&gt;. &lt;i&gt;papatasi&lt;/i&gt; populations from PPAW, PPJM, and PPJS.&lt;/p&gt; &lt;p&gt;(PPTX)&lt;/p&gt;
LONG-TERM FOLLOW-UP OF PERFLUOROCARBON LIQUID IN THE ANTERIOR CHAMBER (1998)

Based on our experience, residual perfluorocarbon liquid droplets in the anterior chamber are well tolerated and do not induce corneal damage or ocular inflammation. These patients should be closely followed, however, and the liquid removed if complications develop.
Deploying and researching Hadoop in virtual machines (2012)

Hadoop's emerging and the maturity of virtualization make it feasible to combine them together to process immense data set. To do research on Hadoop in virtual environment, an experimental environment is needed. This paper firstly introduces some technologies used such as CloudStack, MapReduce and Hadoop. Based on that, a method to deploy CloudStack is given. Then we discuss how to deploy Hadoop in virtual machines which can be obtained from CloudStack by some means, then an algorithm to solve the problem that all the virtual machines which are created by CloudStack using same template have a same hostname. After that we run some Hadoop programs under the virtual cluster, which shows that it is feasible to deploying Hadoop in this way. Then some methods to optimize Hadoop in virtual machines are discussed. From this paper, readers can follow it to set up their own Hadoop experimental environment and capture the current status and trend of optimizing Hadoop in virtual environment.
Spark-GPU: An accelerated in-memory data processing engine on clusters (2016)

Apache Spark is an in-memory data processing system that supports both SQL queries and advanced analytics over large data sets. In this paper, we present our design and implementation of Spark-GPU that enables Spark to utilize GPU's massively parallel processing ability to achieve both high performance and high throughput. Spark-GPU transforms a general-purpose data processing system into a GPU-supported system by addressing several real-world technical challenges including minimizing internal and external data transfers, preparing a suitable data format and a batching mode for efficient GPU execution, and determining the suitability of workloads for GPU with a task scheduling capability between CPU and GPU. We have comprehensively evaluated Spark-GPU with a set of representative analytical workloads to show its effectiveness. Our results show that Spark-GPU improves the performance of machine learning workloads by up to 16.13x and the performance of SQL queries by up to 4.83x.
Spinal Cord Stimulation Improves Survival in Ischemic Skin Flaps: An Experimental Study of the Possible Mediation by Calcitonin Gene-Related Peptide (1999)

Currently, spinal cord stimulation is used to treat ischemia and ischemic pain, with the best results observed in vasospastic cases. It was earlier demonstrated that spinal cord stimulation may attenuate experimentally induced vasospasm in an island flap in the rat. The present study was designed to investigate whether preemptive spinal cord stimulation could increase long-term flap survival and to explore the neurohumoral mediation of the effect. A total of 56 rats were implanted with chronic spinal cord stimulation systems. Three days later, a groin flap based on the superficial epigastric vessels was harvested, and the single feeding artery was occluded by a detachable microvascular clip. After 12 hours, the clip was removed. Flap survival was evaluated after 7 days. Immediately before flap surgery, two groups of animals received 30 minutes of stimulation using current clinical parameters and with stimulation amplitudes of 70 (n = 10) or 90 percent (n = 8) of that evoking muscular contractions. The outcomes in these groups were compared with those in two control groups (n = 20; n = 10). In one group, an additional calcitonin gene-receptor peptide (CGRP) antagonist was intravenously injected before stimulation (n = 8). In the control groups without stimulation, virtually all flaps necrotized. In treated groups, flap survival was 60 percent at the lower intensity and almost 90 percent at the higher one. The administration of a CGRP antagonist before treatment reduced its efficacy to below 40 percent survival. The differences between the untreated and treated groups were significant. The decrease in survival after CGRP-receptor block was significant in one of two tests. Preemptive spinal cord stimulation increases survival of skin flaps with critical ischemia. The effects are dependent on the stimulation intensity and are possibly mediated by the release of CGRP in the periphery. (Plast. Reconstr. Surg. 103: 1221, 1999.)
ChemInform Abstract: DIE BEVORZUGUNG EINER 1‐AXIALEN KONFORM. BEI THIANEN (1972)

Abstract Während die Thian‐Derivate (I)‐(III) überweigend in der axialen Konformation vorliegen, führt eine 3,3‐Dimethyl‐Gruppierung zu einer äquatorialen Konformation wie (IV)‐(VI), während eine 4,4‐Dimethyl‐Konfiguration axiale Strukturen (VII)‐(IX) ergibt.
Fast Prototyping Flow for Sensor Interfaces (2006)

Sensor applications require always more performing sensors together with size, power and area reduction. For this reason a Platform Based Design has been developed in order to implement an Intelligent Sensor InterFace (ISIF) for conditioning several kinds of MEMS (Micro Electro Mechanical System) sensors. This system is composed of an analog front end and a digital section: analog blocks perform signal acquisition and basic conditioning functions, while few digital IPs perform usually needed Digital Signal Processing such as modulation/demodulation and sine wave generation. A 32-bit RISC (Reduced Instruction Set Computer) processor is also present to implement via software all the Digital Signal Processing (DSP) functions not included in hardware, manage system configuration and provide communication resources. Both analog and digital IPs (Intellectual Property) are highly programmable, as well as their interconnections, in order to provide a wide range of data paths. Several DSP software routines have also been implemented, replicating the behavior of hardware IPs. In this way ISIF can fast prototype a new sensor interface straight in its application field, drastically shortening the development time of full-hardware optimized sensor interfaces.
Inside Back Cover: N‐Heterocyclic Carbene Based Nanolayer for Copper Film Oxidation Mitigation (Angew. Chem. Int. Ed. 25/2022) (2022)

An N-heterocyclic carbene (NHC) nanolayer was produced on copper film and provided an effective passivation layer. The picture featuring the Research Article (e202201093) by Elad Gross et al. highlights the role of the surface-anchored NHC nanolayer in mitigating copper oxidation while demonstrating high thermal and chemical stability.
A new view of macula densa cell protein synthesis (2021)

Macula densa (MD) cells, a chief sensory cell type in the nephron, are endowed with unique microanatomic features including a high density of protein synthetic organelles and secretory vesicles in basal cell processes ("maculapodia") that suggest a so far unknown high rate of MD protein synthesis. This study aimed to explore the rate and regulation of MD protein synthesis and their effects on glomerular function using novel transgenic mouse models, newly established fluorescence cell biology techniques, and intravital microscopy. Sox2-tdTomato kidney tissue sections and an <i>O</i>-propargyl puromycin incorporation-based fluorescence imaging assay showed that MD cells have the highest level of protein synthesis within the kidney cortex followed by intercalated cells and podocytes. Genetic gain of function of mammalian target of rapamycin (mTOR) signaling specifically in MD cells (in MD-mTOR<i><sup>gof</sup></i> mice) or their physiological activation by low-salt diet resulted in further significant increases in the synthesis of MD proteins. Specifically, these included both classic and recently identified MD-specific proteins such as cyclooxygenase 2, microsomal prostaglandin E<sub>2</sub> synthase 1, and pappalysin 2. Intravital imaging of the kidney using multiphoton microscopy showed significant increases in afferent and efferent arteriole and glomerular capillary diameters and blood flow in MD-mTOR<i><sup>gof</sup></i> mice coupled with an elevated glomerular filtration rate. The presently identified high rate of MD protein synthesis that is regulated by mTOR signaling is a novel component of the physiological activation and glomerular hemodynamic regulatory functions of MD cells that remains to be fully characterized.<b>NEW & NOTEWORTHY</b> This study discovered the high rate of protein synthesis in macula densa (MD) cells by applying direct imaging techniques with single cell resolution. Physiological activation and mammalian target of rapamycin signaling played important regulatory roles in this process. This new feature is a novel component of the tubuloglomerular cross talk and glomerular hemodynamic regulatory functions of MD cells. Future work is needed to elucidate the nature and (patho)physiological role of the specific proteins synthesized by MD cells.
Ledipasvir and Sofosbuvir Plus Ribavirin for Treatment of HCV Infection in Patients With Advanced Liver Disease (2015)

Background & Aims There are no effective and safe treatments for chronic hepatitis C virus (HCV) infection of patients who have advanced liver disease. Methods In this phase 2, open-label study, we assessed treatment with the NS5A inhibitor ledipasvir, the nucleotide polymerase inhibitor sofosbuvir, and ribavirin in patients infected with HCV genotypes 1 or 4. Cohort A enrolled patients with cirrhosis and moderate or severe hepatic impairment who had not undergone liver transplantation. Cohort B enrolled patients who had undergone liver transplantation: those without cirrhosis; those with cirrhosis and mild, moderate, or severe hepatic impairment; and those with fibrosing cholestatic hepatitis. Patients were assigned randomly (1:1) to receive 12 or 24 weeks of a fixed-dose combination tablet containing ledipasvir and sofosbuvir, once daily, plus ribavirin. The primary end point was sustained virologic response at 12 weeks after the end of treatment (SVR12). Results We enrolled 337 patients, 332 (99%) with HCV genotype 1 infection and 5 (1%) with HCV genotype 4 infection. In cohort A (nontransplant), SVR12 was achieved by 86%–89% of patients. In cohort B (transplant recipients), SVR12 was achieved by 96%–98% of patients without cirrhosis or with compensated cirrhosis, by 85%−88% of patients with moderate hepatic impairment, by 60%–75% of patients with severe hepatic impairment, and by all 6 patients with fibrosing cholestatic hepatitis. Response rates in the 12- and 24-week groups were similar. Thirteen patients (4%) discontinued the ledipasvir and sofosbuvir combination prematurely because of adverse events; 10 patients died, mainly from complications related to hepatic decompensation. Conclusion The combination of ledipasvir, sofosbuvir, and ribavirin for 12 weeks produced high rates of SVR12 in patients with advanced liver disease, including those with decompensated cirrhosis before and after liver transplantation. ClinTrials.gov: NCT01938430.
Attosecond, High-Harmonic Optical Vortices with Tailored Spin and Orbital Angular Momentum (2019)

Extreme-ultraviolet, attosecond beams with custom spin and orbital angular momentum are produced via high-harmonic generation, for the first time. Entwined angular momentum conservation rules yield exquisite control over their polarization, divergence, and vortex charge.
Progesterone as a Bone-Trophic Hormone (1990)

Experimental, epidemiological, and clinical data indicate that progesterone is active in bone metabolism. Progesterone appears to act directly on bone by engaging an osteoblast receptor or indirectly through competition for a glucocorticoid osteoblast receptor. Progesterone seems to promote bone formation and/or increase bone turnover. It is possible, through estrogen-stimulated increased progesterone binding to the osteoblast receptor, that progesterone plays a role in the coupling of bone resorption with bone formation. A model of the interdependent actions of progesterone and estrogen on appropriately-"ready" cells in each bone multicellular unit can be tied into the integrated secretions of these hormones within the ovulatory cycle. Figure 5 is an illustration of this concept. It shows the phases of the bone remodeling cycle in parallel with temporal changes in gonadal steroids across a stylized ovulatory cycle. Increasing estrogen production before ovulation may reverse the resorption occurring in a "sensitive" bone multicellular unit while gonadal steroid levels are low at the time of menstrual flow. The bone remodeling unit would then be ready to begin a phase of formation as progesterone levels peaked in the midluteal phase. From this perspective, the normal ovulatory cycle looks like a natural bone-activating, coherence cycle. Critical analysis of the reviewed data indicate that progesterone meets the necessary criteria to play a causal role in mineral metabolism. This review provides the preliminary basis for further molecular, genetic, experimental, and clinical investigation of the role(s) of progesterone in bone remodeling. Much further data are needed about the interrelationships between gonadal steroids and the "life cycle" of bone. Feldman et al., however, may have been prophetic when he commented; "If this anti-glucocorticoid effect of progesterone also holds true in bone, then postmenopausal osteoporosis may be, in part, a progesterone deficiency disease."
Time to colonoscopy for patients accessing the direct access colonoscopy service compared to the normal service in Newcastle, Australia (2018)

DACS reduces waiting times to colonoscopy and is associated with an increased proportion of patients undergoing colonoscopy in a timely manner.
Validity of Urine Specific Gravity When Compared With Plasma Osmolality as a Measure of Hydration Status in Male and Female NCAA Collegiate Athletes (2015)

Sommerfield, LM, McAnulty, SR, McBride, JM, Zwetsloot, JJ, Austin, MD, Mehlhorn, JD, Calhoun, MC, Young, JO, Haines, TL, and Utter, AC. Validity of urine specific gravity when compared with plasma osmolality as a measure of hydration status in male and female NCAA collegiate athletes. J Strength Cond Res 30(8): 2219-2225, 2016-The purpose of this study was to evaluate the response of urine specific gravity (Usg) and urine osmolality (Uosm) when compared with plasma osmolality (Posm) from euhydration to 3% dehydration and then a 2-hour rehydration period in male and female collegiate athletes. Fifty-six National Collegiate Athletic Association (NCAA) wrestlers (mean ± SEM); height 1.75 ± 0.01 m, age 19.3 ± 0.2 years, and body mass (BM) 78.1 ± 1.8 kg and 26 NCAA women's soccer athletes; height 1.64 ± 0.01 m, age 19.8 ± 0.3 years, and BM 62.2 ± 1.2 kg were evaluated. Hydration status was obtained by measuring changes in Posm, Uosm, Usg, and BM. Male and female subjects dehydrated to achieve an average BM loss of 2.9 ± 0.09% and 1.9 ± 0.03%, respectively. Using the medical diagnostic decision model, the sensitivity of Usg was high in both the hydrated and dehydrated state for males (92%) and females (80%). However, the specificity of Usg was low in both the hydrated and dehydrated states for males (10 and 6%, respectively) and females (29 and 40%, respectively). No significant correlations were found between Usg and Posm during either the hydrated or dehydrated state for males or females. Based on these results, the use of Usg as a field measure of hydration status in male and female collegiate athletes should be used with caution. Considering that athletes deal with hydration status on a regular basis, the reported low specificity of Usg suggests that athletes could be incorrectly classified leading to the unnecessary loss of competition.
Should silicone prostheses be considered for specimen banking? A pilot study into their use for human biomonitoring (2013)

Persistent organic pollutant (POP) biomonitoring in humans is challenging and generally carried out using blood, breast milk or adipose tissue, with concentrations normalised to the lipid content of the sample matrix. The goal of this cross-sectional pilot study was to evaluate the validity and feasibility of explanted silicone prostheses as a matrix for persistent organic pollutant biomonitoring in humans. We postulate that pollutant concentrations in silicone prostheses inserted in the body will equilibrate with that in the body over time and provide a measure of the overall body burden. This study included silicone prostheses from 22 female patients of the Colosseum clinic (Oslo, Norway) collected between September 2010 and April 2012. Absorption of chlorinated and brominated POPs into silicone prostheses during implantation was observed. Relative levels of the different contaminants measured in prostheses were in agreement with those from serum and breast milk analyses from the general Norwegian population. The comparison of serum and breast milk-based literature data with prosthesis concentrations transposed into lipid-normalised concentrations supports the validity of the prosthesis measurements. The median of relative percent differences between measurements with replicate silicone prostheses from 11 patients was below 30%. Observed increases in prosthesis concentrations with patients' age were found to be very similar to literature data from studies of the Norwegian population. Silicone prostheses therefore represent a promising matrix for the biomonitoring of nonpolar and non-ionic pollutants in humans. Sample accessibility and body burden representativeness of the silicone prostheses suggest that specimen banking should be initiated.
From Predictive Models to Instructional Policies. (2015)

At their core, Intelligent Tutoring Systems consist of a student model and a policy. The student model captures the state of the student and the policy uses the student model to individualize instruction. Policies require different properties from the student model. For example, a mastery threshold policy requires the student model to have a way to quantify whether the student has mastered a skill. A large amount of work has been done on building student models that can predict student performance on the next question. In this paper, we leverage this prior work with a new whento-stop policy that is compatible with any such predictive student model. Our results suggest that, when employed as part of our new predictive similarity policy, student models with similar predictive accuracies can suggest that substantially different amounts of practice are necessary. This suggests that predictive accuracy may not be a sufficient metric by itself when choosing which student model to use in intelligent tutoring systems.