gebhart/patrepeval huggingface dataset:
High nevus counts confer a favorable prognosis in melanoma patients (2015)

A high number of nevi is the most significant phenotypic risk factor for melanoma and is in part genetically determined. The number of nevi decreases from middle age onward but this senescence can be delayed in patients with melanoma. We investigated the effects of nevus number count on sentinel node status and melanoma survival in a large cohort of melanoma cases. Out of 2,184 melanoma cases, 684 (31.3%) had a high nevus count (>50). High nevus counts were associated with favorable prognostic factors such as lower Breslow thickness, less ulceration and lower mitotic rate, despite adjustment for age. Nevus count was not predictive of sentinel node status. The crude 5- and 10-year melanoma-specific survival rate was higher in melanomas cases with a high nevus count compared to those with a low nevus count (91.2 vs. 86.4% and 87.2 vs. 79%, respectively). The difference in survival remained significant after adjusting for all known melanoma prognostic factors (hazard ratio [HR] = 0.43, confidence interval [CI] = 0.21-0.89). The favorable prognostic value of a high nevus count was also seen within the positive sentinel node subgroup of patients (HR = 0.22, CI = 0.08-0.60). High nevus count is associated with a better melanoma survival, even in the subgroup of patients with positive sentinel lymph node. This suggests a different biological behavior of melanoma tumors in patients with an excess of nevi.
Micro-textured surfaces for omniphobicity and drag-reduction (2009)

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2009.
Conclusion (2017)

This concluding chapter explores the interplay between state homophobia and discourses and policies geared toward the protection of sexual minorities—which can be referred to as “homoprotectionism.” Like state homophobia, state homoprotectionism can also be instrumental and purposive, serving to legitimate political authority both on a national and on a transnational scale. Although seemingly opposed, the chapter suggests that these two approaches are closely linked and that political authorities rely on a complex interplay of both approaches in order to mobilize consent, or at least to minimize dissent. It also examines the ways in which activists might maneuver the interplay between state homophobia and state homoprotectionism in struggles for sexual justice.
On the Performance of Distributed Polling Service-based Medium Access Control (2008)

It has been shown in the literature that many MAC protocols for wireless networks have a considerable control overhead, which limits their achievable throughput and delay performance. In this paper, we study the problem of improving the efficiency of MAC protocols. We first analyze the popular p- Persistent CSMA scheme and show that it does not achieve 100% throughput.Motivated by insights from polling system theory, we then present three polling service-based MAC schemes, termed PSMACs, for improved performance. The main idea is to serve multiple data frames after a successful contention resolution, thus amortizing the high control overhead and making the protocols more efficient. We present analysis and simulation studies of the proposed schemes. Our results show that PSMAC can effectively improve the throughput and delay performance of p-Persistent CSMA, as well as providing energy savings. We also observe that PSMAC is more efficient for handling the more general and challenging bursty traffic and outperforms p-Persistent CSMA with respect to fairness.
A Core Activity Associated with the N Terminus of the Yeast RAD52 Protein Is Revealed by RAD51 Overexpression Suppression of C-Terminal rad52 Truncation Alleles (1999)

C-terminal rad52 truncation and internal deletion mutants were characterized for their ability to repair MMS-induced double-strand breaks and to produce viable spores during meiosis. The rad52-Delta251 allele, encoding the N-terminal 251 amino acids of the predicted 504-amino-acid polypeptide, supports partial activity for both functions. Furthermore, RAD51 overexpression completely suppresses the MMS sensitivity of a rad52-Delta251 mutant. The absence of the C terminus in the truncated protein makes it likely that suppression occurs by bypassing the C-terminal functions of Rad52p. RAD51 overexpression does not suppress the low level of spore viability that the rad52-Delta251 allele causes and only partially suppresses the defect in rad52 alleles encoding the N-terminal 292 or 327 amino acids. The results of this study also show that intragenic complementation between rad52 alleles is governed by a complex relationship that depends heavily on the two alleles involved and their relative dosage. In heteroallelic rad52 diploids, the rad52-Delta251 allele does not complement rad52 missense mutations altering residues 61 or 64 in the N terminus. However, complementation is achieved with each of these missense alleles when the rad52-Delta251 allele is overexpressed. Complementation also occurs between rad52-Delta327 and an internal deletion allele missing residues 210 through 327. We suggest that the first 251 amino acids of Rad52p constitute a core domain that provides critical RAD52 activities.
ADRC vs LADRC for quadrotor UAV with wind disturbances (2019)

The wind is considered a strong disturbance for quadrotor aircraft. This paper presents two types of double closed-loop control scheme based on ADRC or LADRC for quadrotor aircrafts with wind disturbances, and the comparison and analysis are discussed. Firstly, the turbulent wind field is generated according to the Dryden model and a dynamic model is established via Newton-Euler. Secondly, double closed-loop control schemes based on ADRC or LADRC for quadrotor aircraft are presented respectively. Finally, we evaluate the performance and effectiveness of these control schemes in maintaining stability and tracking the target trajectory. The results of simulation show that the model proposed in the paper accurately reflects the dynamic performance of the quadrotor under the impact of turbulent wind, and the control schemes are effective for quadrotor and they can estimate and compensate for the wind disturbances.
IEEE Body Area Networks for Medical Applications (2007)

IEEE 802.15 working group established a new study group, body area network (SG-BAN), to develop short range wireless communication technology in and around human body recently. Wearable healthcare is an important category of potential applications of BAN. This paper introduces the IEEE SG-BAN and investigates the performance of 802.15.4b and 802.15.4a for wearable healthcare applications in the heterogeneous networks environment. The object is better understanding of healthcare requirement of BAN and how and where BAN works to be started. In addition to the scalability issue, we found asymmetric clear channel assessment (CCA) abilities among different types of wireless technology. The asymmetric CCA has significant impact on system performance.
Correlations of Genotype with Phenotype in Indian Patients with Primary Congenital Glaucoma (2004)

This is the first study to attempt to devise a severity index for grading various PCG phenotypes and to use genotype as an indicator to predict the prognoses of the disorder. This index may help guide therapy and counseling of the afflicted family regarding the progression of the disorder. All patients with severe phenotypes showed poor prognoses (r = 0.976; P < 0.0001). The data derived from this study could be used as an added clinical tool in disease management. Integrated management of PCG that makes use of a genetic approach could yield better results than medical, surgical, and rehabilitation interventions alone.
Securely outsourcing linear algebra computations (2010)

We give improved protocols for the secure and private outsourcing of linear algebra computations, that enable a client to securely outsource expensive algebraic computations (like the multiplication of large matrices) to a remote server, such that the server learns nothing about the customer's private input or the result of the computation, and any attempted corruption of the answer by the server is detected with high probability. The computational work performed at the client is linear in the size of its input and does not require the client to locally carry out any expensive encryptions of such input. The computational burden on the server is proportional to the time complexity of the current practically used algorithms for solving the algebraic problem (e.g., proportional to n3 for multiplying two n x n matrices). The improvements we give are: (i) whereas the previous work required more than one remote server and assumed they do not collude, our solution works with a single server (but readily accommodates many, for improved performance); (ii) whereas the previous work required a server to carry out expensive cryptographic computations (e.g., homomorphic encryptions), our solution does not make use of any such expensive cryptographic primitives; and (iii) whereas in previous work collusion by the servers against the client revealed to them the client's inputs, our scheme is resistant to such collusion. As in previous work, we maintain the property that the scheme enables the client to detect any attempt by the server(s) at corruption of the answer, even when the attempt is collusive and coordinated among the servers.
Four dimensional visualization of highly transient fuel sprays by microsecond quantitative x-ray tomography (2009)

An ultrafast x-ray microtomography technique based on synchrotron x rays and a fast-framing x-ray detector was developed to reconstruct the highly transient sprays in four dimensions with microsecond-temporal resolution in the near-nozzle region. The time-resolved quantitative fuel distribution allowed a realistic numerical fluid dynamic simulation with initial conditions based on the measurement, which demonstrates that the fuel has completed the primary breakup upon exiting the nozzle. The secondary-breakup-based simulation agrees well with the experimental fuel-volume fraction distribution, which challenges most existing simulation assumptions and results.
Free Neurovascular Transfer of Latissimus Dorsi Muscle to the Bladder. I. Experimental Studies (1997)

The "tension-torsion" reconfiguration produced intraluminal pressures which should enable stimulated striated muscle to evacuate bladder-like reservoirs successfully. Microneurovascular free transfer of latissimus dorsi muscle resulted in reinnervated, functional muscle in the pelvis. Augmentation cystoplasty using the latissimus dorsi in conjunction with a free omental flap for substitution of an accompanying mucosal defect was unsuccessful. The concept of microneurovascular transfer of latissimus dorsi muscle to the pelvis may be used for complicated fistula of the lower urinary tract, and may be a possible solution for the therapy resistent acontractile bladder.
Magnetic Properties of Zinc Sulfide Phosphors with Manganese Activator (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMagnetic Properties of Zinc Sulfide Phosphors with Manganese ActivatorSimon Larach and John TurkevichCite this: J. Phys. Chem. 1956, 60, 11, 1598Publication Date (Print):November 1, 1956Publication History Published online1 May 2002Published inissue 1 November 1956https://pubs.acs.org/doi/10.1021/j150545a038https://doi.org/10.1021/j150545a038research-articleACS PublicationsRequest reuse permissionsArticle Views48Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Camouflaging Nanoparticles for Ratiometric Delivery of Therapeutic Combinations (2019)

Combination therapy is a common clinical practice in the management of malignancies. Synergistic therapeutic outcomes are achieved only when tumor cells are exposed to drugs in an optimal ratio and sequence; therefore, carriers coencapsulating multiple drugs are widely pursued for their coordinated delivery. However, it is challenging to coload drugs with different physicochemical properties in a single carrier with specific ratios. It is not even beneficial to load them in one carrier if they need to be released at different times. We propose to load drugs into chemically compatible carriers separately, equalize different carriers by a simple, rapid, and versatile camouflage technique based on natural polyphenol tannic acid (TA), and administer them in desirable ratios and sequences. To demonstrate this potential, different nanoparticles (NPs) with different charges and material basis, such as polymeric (carboxyl-terminated or amine-terminated cationic polystyrene NPs or poly(lactic- co-glycolic acid (PLGA) NPs), inorganic (mesoporous silica NPs (MSNs)), and liposomal NPs, are camouflaged with TA layers and further modified with folate-conjugated polyethylene glycol to aid in the delivery to tumors. The camouflaged NPs show similar physicochemical properties and interactions with KB cells despite the difference in core platforms, and their mixtures interact with common cell targets in a ratiometric manner. In KB-tumor-bearing mice, the camouflaged PLGA NPs and MSNs show near-perfect colocalization in tumors. These results support that TA helps equalize different NPs with high versatility and enables their ratiometric delivery to common targets. This approach can relieve technical challenges in ratiometric codelivery or sequential delivery of therapeutic agents with distinct physicochemical properties.
An integrated model for an oil free carbon dioxide compressor using Sanderson-Rocker arm motion (S-RAM) mechanism. (2016)

The multi-piston axial reciprocating compressor using the Sanderson-Rocker Arm Motion (S-RAM) mechanism is expected to have high volumetric efficiencies due to the application of a new type of seal to prevent the in-cylinder refrigeration gas leaking through the clearance between piston and cylinder wall. The stroke of the compressor can be controlled by adjusting the inclination angle between the connecting shaft and machine driving shaft. This allows the control of the delivered refrigerant mass flow rate to match the capacity requirement in the field. A comprehensive simulation model to predict the performance of a prototype reciprocating compressor using the SRAM mechanism has been developed. The natural refrigerant carbon dioxide (CO2) is used as the working fluid. The comprehensive model is comprised of a kinematics model, compression process model and an overall energy balance model. In the kinematics model, the movement of the piston is given including its displacement, velocity and acceleration. It is found that the moving path of the center of the ball in the ball-socket joint is moving around a corresponding cylinder centerline with a ‘figure 8’ motion instead of moving along the cylinder centerline. In the compression process model, the system of governing equations is solved, which incorporates a valve sub-model, leakage sub-model and gas pulsation sub-model. The classical 4th order Runge-Kutta method and Broyden’s method are employed to solve the non-linear system of equations to find the in-cylinder refrigerant state (temperature, pressure) at each rotational angle of the machine driving shaft. The variations of suction and discharge valve movements with respect to drive shaft rotational angle are also given. The values of the cylinder wall temperature, the actual suction and discharge temperatures in the connecting pipes are required to initiate the solving of the compression process model. These temperatures are solved simultaneously by incorporating the overall energy balance model with the compression process model. A lumped temperature assumption is employed in the overall energy balance model to assume there is no temperature gradient in each compressor component at steady-state.
A Classification of Unimodular Lattice Wiretap Codes in Small Dimensions (2012)

Lattice coding over a Gaussian wiretap channel, where an eavesdropper listens to transmissions between a transmitter and a legitimate receiver, is considered. A new lattice invariant called the secrecy gain is used as a code design criterion for wiretap lattice codes since it was shown to characterize the confusion that a chosen lattice can cause at the eavesdropper: the higher the secrecy gain of the lattice, the more confusion. In this paper, a formula for the secrecy gain of unimodular lattices is derived. Secrecy gains of extremal odd unimodular lattices as well as unimodular lattices in dimension n, 16 \leq n \leq 23 are computed, covering the 4 extremal odd unimodular lattices and all the 111 nonextremal unimodular lattices (both odd and even) providing thus a classification of the best wiretap lattice codes coming from unimodular lattices in dimension n, 8 &lt; n \leq 23. Finally, to permit lattice encoding via Construction A, the corresponding error correction codes are determined.
Guinea pig alveolar eosinophils and macrophages produce leukotriene B4 but no peptido-leukotriene. (1990)

The metabolism of arachidonic acid (AA) was investigated in purified guinea pig alveolar eosinophils and macrophages. Alveolar eosinophils produced 12S-hydroxy-5,8,10-heptadecatraenoic acid (HHT) and small amounts only of 5-lipoxygenase products when stimulated by AA (10 microM) or ionophore A23187 (2 microM). However, when the cell suspensions were stimulated with both AA and A23187, the cells produced HHT, leukotriene (LT) B4, and 5S-hydroxy-6,8,11,14-eicosatetraenoic acid, whereas LTC4, D4, and E4 were undetectable. Similarly, alveolar macrophages stimulated with A23187 produced HHT, 5-hydroxy-6,8,11,14-eicosatetraenoic acid, and LTB4 but no peptido-leukotrienes. When LTA4 was added to suspensions of eosinophils and macrophages, only LTB4 was formed, whereas in parallel experiments, intact human platelets incubated with LTA4 produced LTC4. These data suggest that guinea pig alveolar eosinophils and macrophages contain both cyclooxygenase and 5-lipoxygenase, but do not produce peptido-leukotrienes, probably lacking LTA4 glutathione transferase activity. These studies demonstrate that guinea pig eosinophils differ from eosinophils of other animal species which have been shown to be major sources of leukotriene C4. The present data imply that eosinophils and macrophages are not the source of peptido-leukotrienes in anaphylactic guinea pig lungs.
Imaging system fed by a quasi-optical beam-forming network for Ka-band satellite applications (2016)

A quasi-optical system in Substrate Integrated Waveguide (SIW) technology is proposed to feed the primary array of an imaging system for satellite applications in Ka-band. An in-house Physical Optics (PO) tool is used for the complete antenna design reducing the phase aberrations of the imaging system and at the same time improving the Earth coverage by the Satellite. Measurement results validate the overall approach.
Novell NetWare for users (1996)

Designed to be used in an introductory computer course that briefly covers local area networks and Novell NetWare. Topics covered include organization of the server disk; renaming, deleting, and recovering files and directories; using the FILER menu utility; file rights; drive mapping, print queuing; print jobs; and controlling printing.
Synthesis, characterization, and antimicrobial activity of novel substituted 2H-chromenyl acrylates (2016)

The present study deals with conventional Witting olefination of 2H-chromene-3-carbaldehydes with stabilized ylide in the presence of dichloromethane to afford (2E)-ethyl-3-(4-chloro-2H-chromen-3-yl) acrylate derivatives. All the products were found to have E-geometry at C=C bond. The synthesized compounds were characterized by spectral data such as IR, 1H NMR and MS. Compounds were screened for antimicrobial activity against strains of gram positive, gram negative bacterial and fungal strains. All compounds showed good antibacterial and antifungal activity.
Improving maximal safe brain tumor resection with photoacoustic remote sensing microscopy (2020)

Malignant brain tumors are among the deadliest neoplasms with the lowest survival rates of any cancer type. In considering surgical tumor resection, suboptimal extent of resection is linked to poor clinical outcomes and lower overall survival rates. Currently available tools for intraoperative histopathological assessment require an average of 20 min processing and are of limited diagnostic quality for guiding surgeries. Consequently, there is an unaddressed need for a rapid imaging technique to guide maximal resection of brain tumors. Working towards this goal, presented here is an all optical non-contact label-free reflection mode photoacoustic remote sensing (PARS) microscope. By using a tunable excitation laser, PARS takes advantage of the endogenous optical absorption peaks of DNA and cytoplasm to achieve virtual contrast analogous to standard hematoxylin and eosin (H&E) staining. In conjunction, a fast 266 nm excitation is used to generate large grossing scans and rapidly assess small fields in real-time with hematoxylin-like contrast. Images obtained using this technique show comparable quality and contrast to the current standard for histopathological assessment of brain tissues. Using the proposed method, rapid, high-throughput, histological-like imaging was achieved in unstained brain tissues, indicating PARS' utility for intraoperative guidance to improve extent of surgical resection.
A reservation based multiple access scheme for a future Universal Mobile Telecommunications System (1993)

A future Universal Mobile Telecommunications System (UMTS), encompasses the concept of an air-interface that is able to deliver a variety of services to the mobile user, in the full compliment of environments. The RACE ATDMA project is engaged in a research and development programme to design, develop and evaluate an advanced time division multiple access (ATDMA) implementation of a UMTS system. Central to the realisation of this UMTS system is the multiple access scheme, that must efficiently multiplex channels supporting the range of services onto the air-interface, in each of the three cell types, whilst making optimum use of the allocated spectrum. The author presents a reservation based multiple access scheme to meet the requirements of UMTS, supported by an ATDMA air-interface. This multiple access scheme has become known within the RACE ATDMA project as PRMA++.
Potentially Unstable Intertrochanteric Fractures (2005)

A surgeon must be aware of iatrogenic fragmentation of the lateral cortex at the time of surgery in apparently stable intertrochanteric fractures in older patients because of the potential for subsequent loss of reduction.