gebhart/patrepeval huggingface dataset:
EXPRESSION OF THE TRANSFORMED PHENOTYPE INDUCED BY DIVERSE ACTING VIRAL ONCOGENES MEDIATES SENSITIVITY TO GROWTH SUPPRESSION INDUCED BY CAFFEIC ACID PHENETHYL ESTER (CAPE) (1994)

Caffeic acid phenethyl ester (CAPE) displays enhanced growth suppressive and toxic effects toward cloned rat embryo fibroblast (CREF) cells transformed by adenovirus type 5 (Ad5) or the Ad5 E1A transforming gene versus untransformed CREF cells (Su et al, Mol Carcinogen 4: 231-242, 1991). The present study was conducted to determine if transformation of CREF cells with additional oncogenes rendered these cells sensitive to the antiproliferative effect of CAPE. Additionally, studies were conducted to determine if reversion of the transformed phenotype could modify CAPE sensitivity. CAPE displayed increased growth suppressive activity toward CREF cells transformed by a number of oncogenes, including Ha-ras, v-src, v-raf, human papillomavirus type 18 (HPV-18) and human papillomavirus type 51 (HPV-51). Employing Ha-ras-transformed CREF (Ha-ras) and Ha-ras-transformed CREF cells overexpressing the Krev-1 suppressor gene (Ha-ras/Krev-1), evidence for a direct relationship between expression of the transformed phenotype and CAPE sensitivity was demonstrated. Ha-ras/Krev-1 cells displaying a suppression of the transformed phenotype exhibited increased resistance to CAPE-induced growth suppression versus Ha-ras cells, whereas Ha-ras/Krev-1 cells escaping transformation-suppression following in vivo growth in nude mice displayed enhanced sensitivity to growth-suppression induced by CAPE. Similarly, mutant Ad5 (H5hr1)-transformed and v-src-transformed CREF cells displaying a stable reversion in transformation also displayed a reduced sensitivity to CAPE versus their transformed counterparts. These observations indicate a direct relationship between expression of the transformed phenotype and CAPE sensitivity. Elucidation of the mechanism by which CAPE selectively inhibits growth of transformed cells should provide important insights into the critical molecular changes mediating expression of the transformed state and could help identify cellular targets for cancer therapy.
Positronium as a probe of transient paramagnetic centers ina−SiO2 (2007)

A laser-pump, positron-probe technique has been developed for measuring the dynamics of laser-induced paramagnetic centers in porous materials. The basis of the technique is the fact that the annihilation rate of ortho-positronium may increase in the presence of unpaired spins. By using an intense positron pulse to create positronium atoms in a porous silica sample we have used this effect as a probe to measure the time dependence of the recombination of laser-induced paramagnetic centers. We have observed nonexponential postirradiation decay kinetics extending over ten orders of magnitude that are similar to those previously observed in silica glasses.
Arterial lipid characterization by high resolution TSI (2006)

High resolution Thermal Strain Imaging (TSI) using an ultrasound (US) microscope was applied to excised porcine tissues. Samples were placed in a temperature controlled water chamber and scanned transversely and longitudinally using a custom high resolution microscope. Phase-sensitive, correlation-based speckle tracking was applied to map the spatial distribution of temporal strain across the sample. TSI differentiated fatty tissue from the water- based arterial wall and muscle with high contrast and a spatial resolution of 60 microns for a 50 MHz transducer. Both transverse and longitudinal TSI images compare well with the B-Scan of arterial wall structures, including intima, media, adventitia and overlying fatty tissue. These in-vitro results demonstrate the feasibility of high resolution TSI with a small temperature change (less than a 1°C) for plaque characterization.
Carbon-13 nuclear magnetic resonance study of the conformations of disulfides and their oxide derivatives (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbon-13 nuclear magnetic resonance study of the conformations of disulfides and their oxide derivativesFillmore Freeman and Christos N. AngeletakisCite this: J. Org. Chem. 1982, 47, 22, 4194–4200Publication Date (Print):October 1, 1982Publication History Published online1 May 2002Published inissue 1 October 1982https://pubs.acs.org/doi/10.1021/jo00143a004https://doi.org/10.1021/jo00143a004research-articleACS PublicationsRequest reuse permissionsArticle Views303Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Bio-Inspired Antifouling Strategies (2012)

Biofouling is a complex, dynamic problem that globally impacts both the economy and environment. Interdisciplinary research in marine biology, polymer science, and engineering has led to the implementation of bio-inspired strategies for the development of the next generation of antifouling marine coatings. Natural fouling defense mechanisms have been mimicked through chemical, physical, and/or stimuli-responsive strategies. This review outlines the detrimental effects associated with biofouling, describes the theoretical basis for antifouling coating design, and highlights prominent advances in bio-inspired antifouling technologies.
Scalable Interpretable Multi-Response Regression via SEED (2016)

Sparse reduced-rank regression is an important tool to uncover meaningful dependence structure between large numbers of predictors and responses in many big data applications such as genome-wide association studies and social media analysis. Despite the recent theoretical and algorithmic advances, scalable estimation of sparse reduced-rank regression remains largely unexplored. In this paper, we suggest a scalable procedure called sequential estimation with eigen-decomposition (SEED) which needs only a single top-$r$ singular value decomposition to find the optimal low-rank and sparse matrix by solving a sparse generalized eigenvalue problem. Our suggested method is not only scalable but also performs simultaneous dimensionality reduction and variable selection. Under some mild regularity conditions, we show that SEED enjoys nice sampling properties including consistency in estimation, rank selection, prediction, and model selection. Numerical studies on synthetic and real data sets show that SEED outperforms the state-of-the-art approaches for large-scale matrix estimation problem.
P313 Within, 6 months from COVID-19 BNT162b2 vaccine patients with Inflammatory Bowel Diseases treated with Anti-TNFα have significantly lower serologic responses (2022)

Abstract Background While vaccines against COVID-19 are effective in healthy individuals, we reported significantly lower serologic responses to BNT162b2 in patients with inflammatory bowel diseases (IBD) treated with anti-tumor necrosis factor (TNF) α agents. As this was apparent already, 4 weeks post vaccination, vaccine longevity is concerning. Aim: to assess long-term serologic responses to BNT162b2 in patients with IBD stratified according to medical treatment. Methods A prospective, observational multi-center Israeli study. Patients with IBD (anti-TNFα treated versus non-anti-TNFα treated) and healthy controls (HC) were followed from before the, 1st BNT162b2 dose until, 6 months after vaccination. COVID-19 spike (S) and nucleocapsid (N) antibodies (Abs) concentrations were analyzed by ELISA, followed by neutralization studies. Specific anti-receptor binding domain (RBD) memory B-cells response, serologic responses against variants of concern (VOCs), Beta, Gamma and Delta, immunoglobulin levels and lymphocyte cell subsets were evaluated as well. Safety was assessed using questionnaires, clinical and laboratory data. Results Of, 193 subjects, 130 had IBD (45 and, 85 in the anti-TNFα and non-anti-TNFα groups, respectively), 63 HC. Serologic response assessed, 176 (median) days (IQR, 166–186) and compared to, 4 weeks after, 1st dose significantly declined in all three groups, but was lowest in the anti-TNFα group:, 6 months anti-S Abs titer geometric means:, 193 (95%CI:, 128–292), 703 (520–951), and, 1253 (1023–1534) in anti-TNFα, non- anti-TNFα and HC groups, respectively, p&amp;lt;0.001, Figure, 1. This was further supported by neutralization and inhibition studies. Importantly, significantly decreased memory B-cell response towards RBD was detected only in the anti-TNFα group, with the most significant reduction in response to Beta VOC (p&amp;lt;0.0008 and p&amp;lt;0.0001, vs. non-anti-TNFα and HC, respectively). Older age was an additional predictor of lower serologic response. Immunoglobulin levels and lymphocyte cell subsets were comparable between the study groups. Infection rate reflected by anti-N Abs was ~1% in all groups. Safety was comparable in all groups. Conclusion The, 6-months serologic response to BNT162b2 vaccine, evaluated prospectively, decreased in all subjects, most prominently in patients with IBD treated with anti-TNFα. Importantly, the latter also had the sharpest decline in serologies, the lowest functional activity and lowest RBD specific memory B-cells. Older age is an additional predictor of decreased serologic response. Altogether, waning of COVID-19 serologic and functional response over, 6 months, specifically in patients with IBD treated with anti-TNFα, supports the need for an early third vaccine dose.
Flotation behavior of hard-to-separate and high-ash fine coal (2016)

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Correlation between proliferating index and prognostic factors in papillary cystic tumors of the pancreas (1995)

Fifteen cases of papillary cystic tumor of the pancreas (PCTP) were studied (14 female patients, one male patient; mean age: 23.5 years). Most tumors developed in the head of the pancreas as a well circumscribed large mass. The tumor had a mean diameter of 6.7 cm(range; 2 to 15 cm). Histopathologically abundant delicate papillary fragments, monomorphic tumor cells and degenerative changes of the solid area of the tumor were characteristic. All but two cases had completely circumscribed capsules. Two cases had duodenal invasion; one of all cases had cul de sac metastasis. Compared with 12 non-aggressive tumors, the aggressive cases had larger tumor size (more than 9 cm) with a thicker capsule (more than 2 mm). In studies to investigate the prognostic index using nucleolar organizing region (NOR), proliferating cell nuclear antigen (PCNA) and flow cytometry as well as nuclear grade and mitotic index, we could not find the useful parameter to detect the malignant potential of PCTP. In the flow cytometric analysis of cellular DNA contents, two invasive cases and the only one case of the male patient among the non-aggressive group were aneuploid. In conclusion, although it is hard to predict the prognosis by microscopic findings only, those with a thick capsule and aneuploidy tend to be related to malignant potential.
Anionic Salt Programs for Close-Up Dry Cows (1998)

of all mature cows are estimated to be hypocalcemic at calving.Drops in plasma calcium pools cause hypocalcemia.Calcium is vital to smooth muscle contraction.Therefore, postpartum subclinical hypocalcemia affects the reproductive tract's involution process, and gut motility.Normal blood calcium is 8 to 12 milligrams per decaliter (mg/dl).Blood calcium reduced to 7.5 or 5 mg/dl can lower abomasal motility by 30 and 70 percent, respectively.Reduced abomasal motility from low blood calcium lowers feed intake and displaces the abomasum.Traditionally, hypocalcemia was thought to be caused by improper dietary calcium levels in the dry period.High calcium intakes in the dry period (more than 70 grams of calcium per day) were thought to suppress the cow's ability to use bone stores at calving, thereby inducing milk fever.
Monolithic integration of ultraviolet microdisk lasers into photonic circuits in a III-nitride-on-silicon platform (2020)

Ultraviolet microdisk lasers are integrated monolithically into photonic circuits using a III-nitride-on-silicon platform with gallium nitride (GaN) as the main waveguide layer. The photonic circuits consist of a microdisk and a pulley waveguide, terminated by out-coupling gratings. In this Letter, we measure quality factors up to 3500 under continuous-wave excitation. Lasing is observed from 374 to 399 nm under pulsed excitation, achieving low-threshold energies of 0.14<i>m</i><i>J</i>/<i>c</i><i>m</i><sup>2</sup> per pulse (threshold peak powers of 35<i>k</i><i>W</i>/<i>c</i><i>m</i><sup>2</sup>). A large peak-to-background dynamic of around 200 is observed at the out-coupling grating for small gaps of 50 nm between the disk and the waveguide. These devices operate at the limit of what can be achieved with GaN in terms of operation wavelength.
Control of manufacturing systems using state feedback and linear programming (2006)

Most studies on control of discrete event manufacturing systems focus on control in the event domain. However, in real-life production environments, events occur while time elapses. In this study we develop an explicit state feedback controller in a model predictive control (MPC) setting for the class of manufacturing systems where only communication and no choice occurs. The state of the manufacturing system is specified as a function of time instead of events. For larger systems, where explicit feedback control is too difficult or time consuming, we present an MPC control framework based on repeatedly solving linear programming problems.
Intraocular Manifestations of Non-Hodgkin Lymphoma (2000)

Objective: This study aimed to describe the various ocular presentations of systemic non-Hodgkin lymphoma and non-Hodgkin lymphoma of the central nervous system in Taiwan. Patients and Methods: The authors reviewed the medical and ophthalmologic records of all patients with histopathologically proven non-Hodgkin lymphoma with suspected intraocular involvement who presented at National Taiwan University between 1991 and 1999. Results: There was one patient with non-Hodgkin lymphoma of the central nervous system in the study who presented with vitritis with central serous choroidoretinopathy (CSCR)-like sensory retinal detachment as the first manifestation of lymphoma. Five cases of systemic non-Hodgkin lymphoma were found. The patients’ ocular manifestations included leukemia-like retinopathy, panuveitis, leopard-spot macular lesions, multifocal choroiditis-like lesions and subretinal elevated mounds with vitritis. Ocular manifestations all occurred secondary to systemic lymphoma. Conclusions: Based on these cases, ocular manifestations of non-Hodgkin lymphoma may present with a wide variety of clinical features. Careful ocular examinations of patients suspected to have non-Hodgkin lymphoma are invaluable because they may lead to early diagnosis and optimal management. (Tzu Chi Med J 2000; 12:77-85)
Threading of cyclodextrins onto a polyester of octanedicarboxylic acid and polyethylene glycol (1997)

Abstract A water‐soluble polyester was synthesized from dimethyl octane‐1,8‐dicarboxylate and polyethylene glycol ( M̄ n = 900). This polymer forms water‐soluble inclusion compounds with α‐, β‐ and hydroxypropyl‐α‐cyclodextrin as proven by surface tension measurements, 1 H NMR spectroscopy and titration microcalorimetry. Mainly the octamethylene segments were covered by the cyclodextrins. This inclusion can be used to increase the solubility and the critical micelle concentration of the polyester in water.
Development of novel biopolymer blends based on poly( l ‐lactic acid), poly((R)‐3‐hydroxybutyrate), and plasticizer (2013)

Poly( l ‐lactic acid) (PLLA), a biopolymer that can be derived from renewable resources, is known for its brittleness as a result of slow crystallization rates under supercooling conditions, which is associated with the formation of large spherulites. In addition, the glass transition temperature ( T g ) of PLLA is 60°C, such that the polymer chain is immobile at room temperature. These disadvantages make PLLA unsuitable for use in the food packaging sector. In this research, biopolymer blends based on PLLA and poly((R)‐3‐hydroxybutyrate) (PHB), together with tributyl citrate (TBC) as a plasticizer, were developed. TBC was added to increase polymer chain mobility, and to decrease PLLA T g from 60 to 10°C in blends. Furthermore, the addition of PHB as a nucleating agent to PLLA resulted in an increased proportion of smaller spherulites. Fourier‐transform infrared (FT‐IR) spectroscopy indicated that the carbonyl group and several other characteristic peaks in blends are shifted to lower wavenumber. In addition, polarized optical microscopy experiments confirmed the results of differential scanning calorimetry, FT‐IR, and wide‐angle X‐ray diffraction, showing that PHB enhances the crystallization behavior by acting as a bionucleation. POLYM. ENG. SCI., 54:1394–1402, 2014. © 2013 Society of Plastics Engineers
Abstract WP4: Intravenous Thrombolysis And Outcomes In Patients With Large-vessel Stroke Directly Admitted Or Transferred To A Thrombectomy-capable Center (2023)

Objective: To assess whether the effect of intravenous thrombolysis in patients with large-vessel occlusion differed between patients directly admitted to thrombectomy-capable centers and patients transferred from local stroke centers without thrombectomy capabilities. Methods: We included 3206 patients with an acute ischemic large-vessel stroke with first imaging within 7 hours after onset that were directly admitted to thrombectomy-capable centers and treated with thrombectomy, or transferred from local stroke centers for thrombectomy evaluation, between 2017 and 2021 in Catalonia, Spain. Primary outcome was the degree of disability at 90 days, as evaluated by the shift analysis on the mRs score. Secondary outcomes included mortality at 90 days and the rate of parenchymal hemorrhage and successful reperfusion. Inverse-probability weighting clustered at the type of stroke center was used to estimate the effects. Results: The analysis included 2268 patients (975[49%] treated with thrombolysis) directly admitted to thrombectomy-capable centers and 938 patients (580[66%] treated with thrombolysis and 616[67%] treated with thrombectomy) transferred from local stroke centers (mean age 72±13 years, median NIHSS score 17[IQR 12-21], 1363 female[48%]). Patients treated with intravenous thrombolysis were younger, had shorter time from onset to first image acquisition, and higher rates of wake-up stroke, atrial fibrillation and anticoagulation intake. The effect of intravenous thrombolysis on the primary outcome was similar in patients directly admitted to thrombectomy-capable centers (acOR 1.50, 95% CI 1.24-1.81) and patients transferred from local stroke centers (acOR 1.44, 95% CI 1.04 to 2.01)(p interaction =0.68). Patients treated with intravenous thrombolysis had lower mortality rate, higher rate of parenchymal hematoma and similar rate of successful reperfusion, with no difference according to type of center (p interaction &gt;0.1). Conclusion: Administration of intravenous thrombolysis in patients with a large-vessel stroke with intention to thrombectomy was associated with higher odds of good functional outcome and higher rates of parenchymal hematoma, independently of the type of stroke center were it was administered.
DNA microarrays with stem–loop DNA probes: preparation and applications (2001)

We have developed DNA microarrays containing stem-loop DNA probes with short single-stranded overhangs immobilized on a Packard HydroGel chip, a 3-dimensional porous gel substrate. Microarrays were fabricated by immobilizing self-complementary single-stranded oligonucleotides, which adopt a partially duplex structure upon denaturing and re-annealing. Hybridization of single-stranded DNA targets to such arrays is enhanced by contiguous stacking interactions with stem-loop probes and is highly sequence specific. Subsequent enzymatic ligation of the targets to the probes followed by stringent washing further enhances the mismatched base discrimination. We demonstrate here that these microarrays provide excellent specificity with signal-to-background ratios of from 10- to 300-fold. In a comparative study, we demonstrated that HydroGel arrays display 10-30 times higher hybridization signals than some solid surface DNA microarrays. Using Sanger sequencing reactions, we have also developed a method for preparing nested 3'-deletion sets from a target and evaluated the use of stem-loop DNA arrays for detecting p53 mutations in the deletion set. The stem-loop DNA array format is simple, robust and flexible in design, thus it is potentially useful in various DNA diagnostic tests.
Eccentric and Concentric Resistance Exercise Comparison for Knee Osteoarthritis (2019)

Both resistance training types effectively increased leg strength. Knee flexion and knee extension muscle strength can modify function and pain symptoms irrespective of muscle contraction type. Which mode to pick could be determined by preference, goals, tolerance to the contraction type, and equipment availability.
Transformation‐Induced Magnetoelasticity in FeGa Alloys (2019)

Global or local phase transformations are commonly used to create or improve useful properties of materials: the functionality of shape memory alloys is enabled by a global thermoelastic transformation. Transformation‐induced plasticity (TRIP) steels and the creation of transformation‐toughened ceramics are examples of materials innovations through local martensitic phase transformations. This research is undertaken to elucidate the nature of the large magnetostriction in FeGa alloys. An investigation of the evolution of the alloy's nanostructure in the varying magnetic fields of the objective lens of an electron microscope reveals the mechanism leading to the large magnetostriction; it is caused by a local martensitic transformation of the DO 3 nanoprecipitates to a 6M phase, leading to transformation‐enhanced magnetoelasticity. The analysis of macroscopic elastic, magnetostriction, and magnetic torque data corroborates this finding.