gebhart/patrepeval huggingface dataset:
Acute effect of furosemide on renal kallikrein and prostaglandin systems in mild to moderate essential hypertension. (1987)

The activity of basal 24-hour urinary kallikrein activity (UKA), prostaglandin E2 (U. PGE2) and thromboxane B2 (U. TxB2) and their relationship to natriuresis (U. Sodium), urinary aldosterone (U. Aldosterone) and plasma renin activity (in supine position: PRA1; in standing position: PRA2) were evaluated in 20 patients with early-moderate hemodynamically defined (first pass and gate blood pool radionuclide angiocardiography) essential hypertension (H) and in 13 age-matched normotensive patients (N). In basal conditions, UKA and PRA2 were significantly reduced (p less than 0.005 and p less than 0.05, respectively) in H compared with N. However, no differences between N and H were found for U. TxB2, U. PGE2, U. Aldosterone, U. Sodium, and PRA1. All parameters were also evaluated both in H and N before and after the administration of furosemide (40 mg i.v.). In H, but not in N, furosemide induced an increase of UKA (p less than 0.05), U. TxB2 (p less than 0.05) and U. Sodium (p less than 0.001). In both H and N furosemide caused a significant rise of PRA1 (p less than 0.001 in H and p less than 0.01 in N) and PRA2 (p less than 0.001 in H and p less than 0.05 in N). In H a significant correlation was found between percent increases of U. Sodium and U. Kallikrein (r = 0.54, p less than 0.01) and between percent differences of PGE2 and TxB2 (r = 0.59, p less than 0.01). It is proposed that reduction of basal UKA may be an early evidence of the first stages of hypertension, i.e., in absence of renal and cardiovascular alteration. The finding is not accompanied by significant changes in urinary excretion of arachidonic acid metabolites and aldosterone. Finally, any relation between UKA values and systemic hemodynamics is lacking.
Current progress and limitations of spider silk for biomedical applications (2011)

Spider silk is a fascinating material combining remarkable mechanical properties with low density and biodegradability. Because of these properties and historical descriptions of medical applications, spider silk has been proposed to be the ideal biomaterial. However, overcoming the obstacles to produce spider silk in sufficient quantities and in a manner that meets regulatory demands has proven to be a difficult task. Also, there are relatively few studies of spider silk in biomedical applications available, and the methods and materials used vary a lot. Herein we summarize cell culture- and in vivo implantation studies of natural and synthetic spider silk, and also review the current status and future challenges in the quest for a large scale production of spider silk for medical applications.
Substitution reactions which proceed via radical anion intermediates. 26. Oxidative substitution of nitroparaffin salts (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSubstitution reactions which proceed via radical anion intermediates. 26. Oxidative substitution of nitroparaffin saltsNathan Kornblum, Haribansh K. Singh, and William J. KellyCite this: J. Org. Chem. 1983, 48, 3, 332–337Publication Date (Print):February 1, 1983Publication History Published online1 May 2002Published inissue 1 February 1983https://pubs.acs.org/doi/10.1021/jo00151a011https://doi.org/10.1021/jo00151a011research-articleACS PublicationsRequest reuse permissionsArticle Views624Altmetric-Citations68LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Contribution of circular dichroism below 185 m.mu. to the optical rotatory dispersion of cytochrome b2 (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTContribution of circular dichroism below 185 m.mu. to the optical rotatory dispersion of cytochrome b2Tian Yow Tsong and Julian M. SturtevantCite this: J. Am. Chem. Soc. 1969, 91, 9, 2382–2384Publication Date (Print):April 1, 1969Publication History Published online1 May 2002Published inissue 1 April 1969https://pubs.acs.org/doi/10.1021/ja01037a039https://doi.org/10.1021/ja01037a039research-articleACS PublicationsRequest reuse permissionsArticle Views22Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Performance Investigation of a Quasi-Optical NbN HEB Mixer at Submillimeter Wavelength (2009)

In this paper, the performance of a quasi-optical phonon-cooled NbN superconducting hot electron bolometer (HEB) mixer is thoroughly investigated. The variation of the receiver noise temperature and the conversion gain around 600 GHz with respect to DC bias voltage and LO pumping level has been measured. The lowest receiver noise temperature is 750 K and reduced to about 250 K after correcting the quasi-optical losses before the HEB mixer. We compared the measured results with the predictions according to one dimensional distributed hot spot model. A reasonable match between theoretical model and experiment is observed. In addition, the direct response of the HEB mixer (integrated with a log-periodic spiral antenna) is measured by using Fourier Transform Spectrometer (FTS). The stability of the receiver is also investigated by means of Allan variance time measurements performed with an intermediate frequency (IF) bandwidth of 40 MHz.
Messenger RNA Translation Defects in Neurodegenerative Diseases (2023)

Aberrant mRNA translation is a prominent feature in many neurodegenerative diseases. The pathological hallmark is abnormally folded protein aggregates, with a unique molecular composition.
E-beam inspection of EUV mask defects: To etch or not to etch? (2014)

EUV Lithography is aimed to be inserted into mainstream production for sub-20nm pattern fabrication. Unlike conventional optical lithography, frequent defectivity monitors (adders, repeaters etc.) are required in EUV lithography. Due to sub-20nm pattern and defect dimensions e-beam inspection of critical pattern areas is essential for yield monitor. In previous work we showed sub-10nm defect detection sensitivity<sup>1</sup> on patterned resist wafers. In this work we report 8-10&times; improvement in scan rates of etched patterns compared to resist patterns without loss in defect detection sensitivity. We observed good etch transfer of sub-10nm resist features. A combination of smart scan strategies with improved etched pattern scan rates can further improve throughput of e-beam inspection. An EUV programmed defect mask with Line/Space, Contact patterns was used to evaluate printability of defects and defect detection (Die-Die and Die-Database) capability of the e-beam inspection tool. Defect inspection tool parameters such as averaging, threshold value were varied to assess its detection capability and were compared to previously obtained results on resist patterns.
Catalytic Asymmetric Esterification of Ketenes (2005)

Ketene esterification after 100 years: In the latest advance in the esterification of ketenes, Schaefer and Fu described the catalytic asymmetric conversion of 2-tolyl(ethyl)ketene (1) and diphenylacetaldehyde to give the enol ester 2 in 99 % yield and 98 % ee (see scheme).
RESEARCH INITIATIVES - BRIDGES AND STRUCTURES (2002)

This report documents the procedures and products from a research needs focus group meeting held on December 4, 2002. The purpose of the meeting was to identify research needs for bridges and structures in Iowa. The meeting was planned and organized by the Office of Bridges and Structures at the Iowa Department of Transportation (Iowa DOT) with the assistance of Bridge Engineering Center (BEC) personnel at the Center for Transportation Research and Education (CTRE). Participants at the meeting included representatives from Iowa counties, the Iowa DOT, contractors, consultants, universities and pertinent industries. The meeting included break out sessions by general expertise area (design, construction, maintenance) and also sessions involving all participants. A brainstorming session by each of the three break out groups and an associated vote was used to identify prioritized research topics. The three break out groups then developed three or four of these prioritized topics into research initiatives from the brainstorming session. Each break out group briefly presented their research initiatives to all participants in a common session. All participants then voted to prioritize the research initiatives for development of complete research prospectuses (by each break out group). After the prioritized topics were determined, the three break out groups again met separately and developed the research prospectuses for the highly prioritized topics. No further votes were taken on the final prospectuses. All participants met again at the end of the day in a common session to provide final comments for the prospectuses. The report is organized based on the meeting agenda format. Participants and participant information is contained at the beginning of the report. Subsequent information in the report includes products from three meeting sessions.
Figure S2 from Exploiting Arginine Auxotrophy with Pegylated Arginine Deiminase (ADI-PEG20) to Sensitize Pancreatic Cancer to Radiotherapy via Metabolic Dysregulation (2023)

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Not Only for Contact Tracing (2022)

Many countries developed and deployed contact tracing apps to reduce the spread of the COVID-19 coronavirus. Prior research explored people's intent to install these apps, which is necessary to ensure effectiveness. However, adopting contact tracing apps is not enough on its own, and much less is known about how people actually use these apps. Exploring app use can help us identify additional failures or risk points in the app life cycle. In this study, we conducted 13 semi-structured interviews with young adult users of Belgium's contact-tracing app, Coronalert. The interviews were conducted approximately a year after the onset of the COVID-19 pandemic. Our findings offer potential design directions for addressing issues identified in prior work - such as methods for maintaining long-term use and better integrating with the local health systems - and offer insight into existing design tensions such as the trade-off between maintaining users' privacy (by minimizing the personal data collected) and users' desire to have more information about an exposure incident. We distill from our results and the results of prior work a framework of people's decision points in contact-tracing app use that can serve to motivate careful design of future contact tracing technology.
Identification of two distinct Bacillus circulans xylanases by molecular cloning of the genes and expression in Escherichia coli (1989)

Two genes coding for xylanase synthesis in Bacillus circulans were cloned and expressed in Escherichia coli. After digestion of genomic DNA from Bacillus circulans with EcoRI and PstI, the fragments were ligated into the corresponding sites of pUC19 and transformed into Escherichia coli. Restriction enzyme mapping of the two inserts coding for xylanase activity indicated distinctly different nucleotide sequences. Cross-hybridization assays confirmed the absence of sequence homology between the two genes. In vitro transcription-translation assays indicated that the cloned genes encoded for proteins with molecular weights of 22,000 and 59,000. The gene products displayed different substrate specificities. The 22,000-dalton enzyme readily hybrolyzed aspeen, larchwood, and oat spelt xylans, whereas the second was unable to extensively depolymerize oat spelt xylan and resulted in very limited reducing sugar release from any of the xylan substrates tested. Both of the xylanases had isoelectric points of approximately 9.0.
Computational electronics : semiconductor transport and device simulation (1991)

Large computational resources are of ever increasing importance for the simulation of semiconductor processes, devices and integrated circuits. The Workshop on Computational Electronics was intended to be a forum for the dis­ cussion of the state-of-the-art of device simulation. Three major research areas were covered: conventional simulations, based on the drift-diffusion and the hydrodynamic models; Monte Carlo methods and other techniques for the solution of the Boltzmann transport equation; and computational approaches to quantum transport which are relevant to novel devices based on quantum interference and resonant tunneling phenomena. Our goal was to bring together researchers from various disciplines that contribute to the advancement of device simulation. These include Computer Sci­ ence, Electrical Engineering, Applied Physics and Applied Mathematics. The suc­ cess of this multidisciplinary formula was proven by numerous interactions which took place at the Workshop and during the following three-day Short Course on Computational Electronics. The format of the course, including a number of tutorial lectures, and the large attendance of graduate students, stimulated many discussions and has proven to us once more the importance of cross-fertilization between the different disciplines
Early treatment with nitazoxanide prevents worsening of mild and moderate COVID-19 and subsequent hospitalization (2021)

Abstract Background There is an urgent need for treatments to prevent the progression to severe COVID-19 and hospitalization. Methods A randomized double-blind placebo-controlled clinical trial in 36 centers in the U.S. and Puerto Rico investigated the safety and effectiveness of oral nitazoxanide 600 mg twice daily for 5 days in outpatients with symptoms of mild or moderate COVID-19 enrolled within 72 hours of symptom onset. Key objectives were reduction of duration of symptoms (primary) and progression to severe illness (key secondary). Results 1,092 subjects were enrolled, and 379 with laboratory-confirmed SARS-CoV-2 infection were analyzed. Overall, times to sustained clinical recovery were similar for the two arms. Nitazoxanide treatment was associated with an 85% reduction in the progression to severe COVID-19 (1/184, [0.5%] vs. 7/195, [3.6%], p=0.07) and 82% reduction in the rate of hospitalization, emergency room visit or death (1/184 [0.5%] vs. 6/195 [3.1%], p=0.12). In subjects with mild illness at baseline, treatment was also associated with a 3.1-day reduction in median time to sustained clinical recovery and a 5.2-day reduction in time to return to usual health. Nitazoxanide was safe and well tolerated. Conclusions Treatment of mild or moderate COVID-19 with a five-day course of oral nitazoxanide was safe and well tolerated and was associated with an 85% reduction in the progression to severe illness and a 3- to 5-day reduction of the duration of mild illness.
Learning with Plasticity Rules: Generalization and Robustness (2021)

Brains learn robustly, and generalize effortlessly between different learning tasks; in contrast, robustness and generalization across tasks are well known weaknesses of artificial neural nets (ANNs). How can we use our accelerating understanding of the brain to improve these and other aspects of ANNs? Here we hypothesize that (a) Brains employ synaptic plasticity rules that serve as proxies for GD; (b) These rules themselves can be learned by GD on the rule parameters; and (c) This process may be a missing ingredient for the development of ANNs that generalize well and are robust to adversarial perturbations. We provide both empirical and theoretical evidence for this hypothesis. In our experiments, plasticity rules for the synaptic weights of recurrent neural nets (RNNs) are learned through GD and are found to perform reasonably well (with no backpropagation). We find that plasticity rules learned by this process generalize from one type of data/classifier to others (e.g., rules learned on synthetic data work well on MNIST/Fashion MNIST) and converge with fewer updates. Moreover, the classifiers learned using plasticity rules exhibit surprising levels of tolerance to adversarial perturbations. In the special case of the last layer of a classification network, we show analytically that GD on the plasticity rule recovers (and improves upon) the perceptron algorithm and the multiplicative weights method. Finally, we argue that applying GD to learning rules is biologically plausible, in the sense that it can be learned over evolutionary time: we describe a genetic setting where natural selection of a numerical parameter over a sequence of generations provably simulates a simple variant of GD.
Adaptive Predictor Integration for System Performance Prediction (2007)

The integration of multiple predictors promises higher prediction accuracy than the accuracy that can be obtained with a single predictor. The challenge is how to select the best predictor at any given moment. Traditionally, multiple predictors are run in parallel and the one that generates the best result is selected for prediction. In this paper, we propose a novel approach for predictor integration based on the learning of historical predictions. It uses classification algorithms such as k-Nearest Neighbor (k-NN) based supervised learning to forecast the best predictor for the workload under study. Then only the forecasted best predictor is run for prediction. Our experimental results show that it achieved 20.18% higher best predictor forecasting accuracy than the cumulative MSB based predictor selection approach used in the popular network weather service system. In addition, it outperformed the observed most accurate single predictor in the pool for 44.23% of the performance traces.
High resolution thermal light OCT for biological imagery (2002)

We have developed an interference microscope using a tungsten halogen lamp associated with a parallel detection technique to produce en-face (XY) tomographic images with ~1μm×1μm (longitudinal×transverse) resolution. The capabilities of our system are demonstrated by imaging inside various biological tissues.
The AZF proteins (2008)

The azoospermia factor (AZF) locus in Yq11 is now functionally subdivided in three distinct spermatogenesis loci: AZFa, AZFb and AZFc. After knowledge of the complete genomic Y sequence in Yq11, 14 Y genes encoding putatively functional proteins and expressed in human testis are found to be located in one of the three AZF intervals. Therefore, a major question for each infertility clinic performing molecular screening for AZF deletions has now raised concerning the functional contribution of the encoded AZF proteins to human spermatogenesis. Additionally, it has been shown that distinct chromatin regions in Yq11 overlapping with the genomic AZFb and AZFc intervals are probably involved in the pre-meiotic X and Y chromosome pairing process. An old hypothesis on the germ line function of AZF becomes therefore revitalized. It proposed a specific chromatin folding code in Yq11, which controls the condensation cycle of the Y chromosome in the male germ line. Thus, with the exception of AZF proteins functionally expressed during the pre-meiotic differentiation and proliferation of spermatogonia, the need for AZF proteins functionally expressed at meiosis or during the post-meiotic spermatid maturation process is difficult to assess before the identification of specific mutations in the corresponding AZF gene causing male infertility.
Single-user detectors for multiuser channels (1988)

Optimum decentralized demodulation for asynchronous Gaussian multiaccess channels is considered. It is assumed that the receiver is the destination of the information transmitted by only one active user, and single-user detectors that take into account the existence of the other active users in the channel are obtained. The problem considered is one of signal detection in additive colored nonGaussian noise, and attention is focused on one-shot structures where detection of each symbol is based only on the received process during its corresponding interval. Particular emphasis is placed on asymptotically optimum detectors for weak interferers, for CDMA (code-division multiple-access) signature waveforms with long spreading codes, and for low background Gaussian noise level.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Electrocatalytic Voltammetry of Succinate Dehydrogenase:  Direct Quantification of the Catalytic Properties of a Complex Electron-Transport Enzyme (1996)

Succinate dehydrogenase (SDH), the membrane-extrinsic component of Complex II, adsorbs at a pyrolytic graphite edge electrode and catalyzes interconversion of succinate and fumarate depending on the electrochemical potential that is applied. The catalytic activity is measured over a continuous potential range, leading to a quantitative description of the interlinked energetics and kinetics of catalyzed electron transport, including the degree to which the enzyme is intrinsically tuned, at a particular pH, to function either in the direction of succinate oxidation or fumarate reduction. It is revealed that under reversible conditions (i.e. near the reduction potential of the fumarate/succinate couple) and at the physiological temperature of 38 °C, SDH is biased to catalyze fumarate reduction (reversal of the tricarboxylic acid cycle) at pH values below 7.7. Subtle effects which gate electron transport are detected. First, the sharp drop in catalytic activity observed as the potential is made more negative is an intrinsic property that is associated with two-electron/two-proton reduction of the FAD, and second, binding and release of the competitive inhibitor/regulator oxalacetate is observed as the enzyme is cycled between FADox (tight binding) and FADred (weaker binding) states. It is thereby demonstrated how the electron-transport characteristics of a complex redox enzyme, integrating both kinetic and thermodynamic information, can be derived from voltammetric experiments.