gebhart/patrepeval huggingface dataset:
Glucosylceramide synthase inhibition with lucerastat lowers globotriaosylceramide and lysosome staining in cultured fibroblasts from Fabry patients with different mutation types (2018)

Fabry disease is an X-linked lysosomal storage disorder caused by mutations in the GLA gene coding for α-galactosidase A (α-GalA). The deleterious mutations lead to accumulation of α-GalA substrates, including globotriaosylceramide (Gb3) and globotriaosylsphingosine. Progressive glycolipid storage results in cellular dysfunction, leading to organ damage and clinical disease, i.e. neuropathic pain, impaired renal function and cardiomyopathy. Many Fabry patients are treated by bi-weekly intravenous infusions of replacement enzyme. While the only available oral therapy is an α-GalA chaperone, which is indicated for a limited number of patients with specific 'amenable' mutations. Lucerastat is an orally bioavailable inhibitor of glucosylceramide synthase (GCS) that is in late stage clinical development for Fabry disease. Here we investigated the ability of lucerastat to lower Gb3, globotriaosylsphingosine and lysosomal staining in cultured fibroblasts from 15 different Fabry patients. Patients' cells included 13 different pathogenic variants, with 13 cell lines harboring GLA mutations associated with the classic disease phenotype. Lucerastat dose dependently reduced Gb3 in all cell lines. For 13 cell lines the Gb3 data could be fit to an IC50 curve, giving a median IC50 [interquartile range (IQR)] = 11 μM (8.2-18); the median percent reduction (IQR) in Gb3 was 77% (70-83). Lucerastat treatment also dose dependently reduced LysoTracker Red staining of acidic compartments. Lucerastat's effects in the cell lines were compared to those with current treatments-agalsidase alfa and migalastat. Consequently, the GCS inhibitor lucerastat provides a viable mechanism to reduce Gb3 accumulation and lysosome volume, suitable for all Fabry patients regardless of genotype.
A simulation of continuous suspension polymerization of styrene by the Monte Carlo method. (1984)

Reactions (C-l) and (
Assessment of structural integrity of thermoset composite parts subjected to accelerated cooling during the manufacturing process using Puck criteria for failure initiation (2022)

For many applications, the production of large-scale lightweight parts using composite materials requires a curing stage at elevated temperatures with long cycles resulting from necessary heating and cooling steps. Here, an accelerated cooling stage after curing of the matrix can shorten process times and make it possible to demould the components in a hot state. In this paper, the impact of higher cooling rates on residual stresses and strains and the criticality for internal failures are investigated. A literature model using the pultrusion process including thick laminates and the interaction with a production tool was used for the implementation of a thermochemical calculation and an incremental linear-elastic mechanical model to calculate residual stresses induced during manufacturing stage. This way, the capability of flexible simulation environments for handling state of the art calculation schemes is investigated to allow the extension of the physics of those models. The model is implemented in both a representative environment for advanced structural analysis with highly customised element formulation such as Abaqus and a general-purpose FE package. Here, Comsol Multiphysics is used and extended by the calculation of the inter-fibre failure initiation. Using the proposed models applied to a plate geometry, stresses and strains induced in different cooling scenarios are investigated. The assumptions are validated by simulations including the whole curing process, by manufacturing trials on the coupon level and with mechanical tests.
A Review of Antimicrobial Peptides: Defensins and Related Cationic Peptides (1995)

Cationic antimicrobial peptides are present throughout the plant and animal kingdoms and bear striking structural and functional similarities across species lines. They provide primitive, nonspecific means of combating a variety of bacteria, fungi, enveloped viruses, and protozoa. Some are also cytotoxic against host cells, including neoplastic cells. Cationic antimicrobial peptides may play various roles in inflammation and tissue repair. Antimicrobial peptides are found in epithelial tissues regularly exposed to microbial attack as well as in cells whose primary function is defense against potential pathogens. They constitute an important part of the nonoxidative antimicrobial arsenal of leukocytes. They are preformed and/or readily synthesized when the cells are stimulated by exposure to pathogens. They exert their effects directly by inserting into membranes of target cells and forming ion channels which increase membrane permeability; however, antimicrobial peptides can also act as opsonins to facilitate phagocytosis. Resistance to defensins is a virulence factor for organisms such as Salmonella sp. The study of cationic antimicrobial peptides is increasing our understanding of innate immunity, inflammation, and the pathogenesis of genetic diseases such as specific granule disease in humans. Therapeutic applications of antimicrobial peptides are currently under investigation.
A Novel Hybrid Reformer-Electrolyzer-Purifier (REP) for Distributed Production of Low-Cost, Low Greenhouse Gas Hydrogen (2017)

FuelCell Energy with support from the Department of Energy’s Office of Energy Efficiency and Renewable Energy (EERE) has investigated the production of low-cost, low CO2 hydrogen using a molten carbonate fuel cell operating as an electrolyzer. We confirmed the feasibility of the technology by testing a large-scale short stack. Economic analysis was done with the assistance of the National Fuel Cell Center at the University of California, Irvine and we found the technology to be attractive, especially for distributed hydrogen. We explored the performance under various operating parameters and developed an accurate model for further analysis and development calculations. We achieved the expected results, meeting all program goals. We identified additional uses of the technology such as for CO2 capture, power storage, and power load leveling.
VISCI Virtual Intelligent Space for Collaborative Innovation - Project Description (2009)

This paper introduces the Virtual Intelligent Space for Collaborative Innovation (VISCI) multidisciplinary research project. The project has commenced in 2009 and continues until the end of 2012. The main goal for the research is the investigation of virtual collaborative spaces, which allow for rich interaction in innovation activities. The project aims to achieve this through multidisciplinary collaboration and iterative prototype development. The paper will present the background, main objectives, way of implementation and expected results stemming from the research. 1.
◾ Entropy Generation Minimization in Nanofluid Flow (2015)

Extensive studies can be found in the literature on the development of nanofluids and improvements of their thermofluid characteristics both theoretically and experimentally. On the contrary, most of the studies on nanofluids have been conducted from the first law of thermodynamics perspective. The number of investigations on the treatment of nanofluids is less from the second law of thermodynamics (entropy generation analysis) point of view. Nanoparticles available in nanofluids enhance the heat transfer characteristics of the fluid, but at the same time the viscous dissipation due to the increase of the viscosity may be affected considerably. Therefore, entropy generation in nanofluid flows due to both heat transfer and viscous dissipation should be considered to optimize a thermal system’s operating conditions. In addition, complicationssuch as agglomeration and settlement of the nanoparticles introduce new challenges for the thermal and entropy generation analyses.
Projections of disability-adjusted life years for major diseases due to a change in vegetable intake in 2017–2040 in Japan (2021)

Our analysis indicates that increased vegetable consumption would have a significant reduction in the burdens of CVDs, cancer and DKDs in Japan. By estimating the disease burden attributable to low vegetable intake under different scenarios of future vegetable consumption, our study can inform the design of targeted interventions for public health challenges.
What is a Bout of Hibernation? (2019)

Hibernation is organized in bouts which are discrete episodes of decreased activity, metabolism, and body temperature. The lengths of hibernation bouts depend on various factors including species, body weight, ambient temperature, and time of year. The nature of hibernation bouts has been an enduring question. Most often this question has been framed in terms of the function and the control of periodic arousals. A number of studies of the timing of entrances into and arousals from hibernation have suggested that periodic arousals from hibernation are controlled in part by the circadian system. The circadian studies leave open the questions of why temperature influences the number of circadian cycles expressed in each bout, and what is the function of periodic arousals. electroencephalogram studies of golden-mantled ground squirrels entering hibernation revealed that they were predominantly in non-rapid eye movement sleep with rapid eye movement sleep progressively decreasing until it was not evident at all below a brain temperature of 27 °C.
The TLR2 Binding Neisserial Porin PorB Enhances Antigen Presenting Cell Trafficking and Cross-presentation (2017)

TOLL-like receptor (TLR) ligands activate both innate and adaptive immune cells, while modulating the cellular immune response. The outer membrane protein (OMP) from Neisseria meninigitidis, PorB, is a naturally occurring TLR2 ligand and functions as an adjuvant. Here, we demonstrate that PorB increases the level of OVA in the endo-/lysosomal cellular compartment of BMDCs, increases antigen presenting cell (APC) trafficking to draining lymph nodes, and enhances antigen cross-presentation. PorB is capable of mounting an antigen specific T cell response by efficiently stimulating antigen cross-presentation in vivo and in vitro assessed by BMDC OT-I cocultivation assays. The enhanced antigen cross-presentation and the increased APC recruitment to secondary lymphoid tissues expand the scope of known adjuvant effects of PorB on the immune system. Our findings lead to a better understanding of how TLR-ligand based adjuvants can alter and modulate immune responses.
Competitiveness of Rhizobium sp. [Leucaena leucocephala (Lam.) Dewit] strains and their genetically marked derivatives (1996)

Journal Article Competitiveness of Rhizobium sp. [Leucaena leucocephala (Lam.) Dewit] strains and their genetically marked derivatives Get access D.M. Swelim, D.M. Swelim Soil and Water Research Institute, Agricultural Research Center, Giza, Egypt Search for other works by this author on: Oxford Academic Google Scholar L.D. Kuykendall, L.D. Kuykendall United States Department of Agriculture, Soybean and Alfalfa Research Laboratory, Beltsville, MD, USA Search for other works by this author on: Oxford Academic Google Scholar F.M. Hashem, F.M. Hashem United States Department of Agriculture, Soybean and Alfalfa Research Laboratory, Beltsville, MD, USA Search for other works by this author on: Oxford Academic Google Scholar S.M. Abdel‐Wahab, S.M. Abdel‐Wahab Soil and Water Research Institute, Agricultural Research Center, Giza, Egypt Search for other works by this author on: Oxford Academic Google Scholar N.I. Hegazi N.I. Hegazi Faculty of Agriculture, Cairo University, Giza, Egypt Search for other works by this author on: Oxford Academic Google Scholar Letters in Applied Microbiology, Volume 22, Issue 6, 1 June 1996, Pages 443–447, https://doi.org/10.1111/j.1472-765X.1996.tb01199.x Published: 01 June 1996 Article history Received: 19 October 1995 Accepted: 05 December 1995 Published: 01 June 1996
Data from MM-141, an IGF-IR– and ErbB3-Directed Bispecific Antibody, Overcomes Network Adaptations That Limit Activity of IGF-IR Inhibitors (2023)

&lt;div&gt;Abstract&lt;p&gt;Although inhibition of the insulin-like growth factor (IGF) signaling pathway was expected to eliminate a key resistance mechanism for EGF receptor (EGFR)-driven cancers, the effectiveness of IGF-I receptor (IGF-IR) inhibitors in clinical trials has been limited. A multiplicity of survival mechanisms are available to cancer cells. Both IGF-IR and the ErbB3 receptor activate the PI3K/AKT/mTOR axis, but ErbB3 has only recently been pursued as a therapeutic target. We show that coactivation of the ErbB3 pathway is prevalent in a majority of cell lines responsive to IGF ligands and antagonizes IGF-IR–mediated growth inhibition. Blockade of the redundant IGF-IR and ErbB3 survival pathways and downstream resistance mechanisms was achieved with MM-141, a tetravalent bispecific antibody antagonist of IGF-IR and ErbB3. MM-141 potency was superior to monospecific and combination antibody therapies and was insensitive to variation in the ratio of IGF-IR and ErbB3 receptors. MM-141 enhanced the biologic impact of receptor inhibition &lt;i&gt;in vivo&lt;/i&gt; as a monotherapy and in combination with the mTOR inhibitor everolimus, gemcitabine, or docetaxel, through blockade of IGF-IR and ErbB3 signaling and prevention of PI3K/AKT/mTOR network adaptation. &lt;i&gt;Mol Cancer Ther; 13(2); 410–25. ©2013 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Effects of clozapine on the δ‐ and κ‐opioid receptors and the G‐protein‐activated K+ (GIRK) channel expressed in Xenopus oocytes (1998)

1. To investigate the effects of clozapine, an atypical antipsychotic, on the cloned mu-, delta- and kappa-opioid receptors and G-protein-activated inwardly rectifying K+ (GIRK) channel, we performed the Xenopus oocyte functional assay with each of the three opioid receptor mRNAs and/or the GIRK1 mRNA. 2. In the oocytes co-injected with either the delta- or kappa-opioid receptor mRNA and the GIRK1 mRNA, application of clozapine induced inward currents which were attenuated by naloxone, an opioid-receptor antagonist, and blocked by Ba2+, which blocks the GIRK channel. Since the opioid receptors functionally couple to the GIRK channel, these results indicate that clozapine activates the delta- and kappa-opioid receptors and that the inward-current responses are mediated by the GIRK channel. The action of clozapine at the delta-opioid receptor was more potent and efficacious than that at the kappa-opioid receptor. In the oocytes co-injected with the mu-opioid receptor and GIRK1 mRNAs, application of clozapine (100 microM) did not induce an inward current, suggesting that clozapine could not activate the mu-opioid receptor. 3. Application of clozapine caused a reduction of the basal inward current in the oocytes injected with the GIRK1 mRNA alone, but caused no current response in the uninjected oocytes. These results indicate that clozapine blocks the GIRK channel. 4. To test the antagonism of clozapine for the mu- and kappa-opioid receptors, we applied clozapine together with each selective opioid agonist to the oocytes co-injected with either the mu- or kappa-opioid receptor mRNA and the GIRK1 mRNA. Each of the peak currents induced by each selective opioid agonist together with clozapine was almost equal to the responses to a selective opioid agonist alone. These results indicate that clozapine has no significant antagonist effect on the mu- and kappa-opioid receptors. 5. We conclude that clozapine acts as a delta- and kappa-agonist and as a GIRK channel blocker. Our results suggest that the efficacy and side effects of clozapine under clinical conditions may be partly due to activation of the delta-opioid receptor and blockade of the GIRK channel.
Honeycomb Organization of Chitin Nanocrystals (ChNCs) in Nanocomposite Films of UV-Cured Waterborne Acrylated Epoxidized Soybean Oil Emulsified with ChNCs (2021)

Stable biobased waterborne Pickering dispersions of acrylated epoxidized soybean oil (AESO) were developed using chitin nanocrystals (ChNCs) as sole emulsifier without any additives. Thin AESO-ChNC nanocomposite films were produced by UV-curing thin-coated layers of the AESO emulsion after water evaporation. The kinetics of photopolymerization were assessed by monitoring the consumption of the AESO acrylate groups by infrared spectroscopy (Fourier transform infrared (FTIR)). The curing was faster in the presence of ChNCs, with a disappearance of the induction period observed for neat AESO. The coating of AESO droplets with a thin layer of ChNCs was confirmed by scanning electron microscopy (SEM) observation. SEM and transmission electron microscopy (TEM) images revealed the honeycomb organization of ChNCs inside the cured AESO-ChNC films. The mechanical, thermal, and optical properties of the nanocomposite films were studied by dynamic mechanical analysis (DMA), tensile testing, differential scanning calorimetry (DSC), and transmittance measurement, as a function of ChNC content. The inclusion of ChNCs is strongly beneficial to increase the stiffness and strength of the cured films, without compromising its optical transparency. The ability of ChNCs to act as an emulsifier for AESO in replacement of synthetic surfactants and their strong reinforcing effect in UV-cured films offer new opportunities to produce waterborne stable dispersions from AESO for application in biobased coatings and adhesives.
Time-Varying Ankle Mechanical Impedance During Human Locomotion (2014)

In human locomotion, we continuously modulate joint mechanical impedance of the lower limb (hip, knee, and ankle) either voluntarily or reflexively to accommodate environmental changes and maintain stable interaction. Ankle mechanical impedance plays a pivotal role at the interface between the neuro-mechanical system and the physical world. This paper reports, for the first time, a characterization of human ankle mechanical impedance in two degrees-of-freedom simultaneously as it varies with time during walking. Ensemble-based linear time-varying system identification methods implemented with a wearable ankle robot, Anklebot, enabled reliable estimation of ankle mechanical impedance from the pre-swing phase through the entire swing phase to the early-stance phase. This included heel-strike and toe-off, key events in the transition from the swing to stance phase or vice versa. Time-varying ankle mechanical impedance was accurately approximated by a second order model consisting of inertia, viscosity, and stiffness in both inversion-eversion and dorsiflexion-plantarflexion directions, as observed in our previous steady-state dynamic studies. We found that viscosity and stiffness of the ankle significantly decreased at the end of the stance phase before toe-off, remained relatively constant across the swing phase, and increased around heel-strike. Closer investigation around heel-strike revealed that viscosity and stiffness in both planes increased before heel-strike occurred. This finding is important evidence of "pretuning" by the central nervous system. In addition, viscosity and stiffness were greater in the sagittal plane than in the frontal plane across all subgait phases, except the early stance phase. Comparison with previous studies and implications for clinical study of neurologically impaired patients are provided.
Development of Low Parasitic Light Sensitivity and Low Dark Current 2.8 μm Global Shutter Pixel (2018)

<b>Abstract</b>: We developed a low parasitic light sensitivity (PLS) and low dark current 2.8 μm global shutter pixel. We propose a new inner lens design concept to realize both low PLS and high quantum efficiency (QE). 1/PLS is 7700 and QE is 62% at a wavelength of 530 nm. We also propose a new storage-gate based memory node for low dark current. P-type implants and negative gate biasing are introduced to suppress dark current at the surface of the memory node. This memory node structure shows the world smallest dark current of 9.5 e<sup>-</sup>/s at 60 °C.
Applicability of the Zdanovskii rule to sulfide melts (2008)

Applicability of the Zdanovskii rule to melts of the systems Fe-Ni-S and Cu-Ni-S was studied.
Intelligent Computer Numerical Control unit for machine tools (2004)

The paper describes a new CNC control unit for machining centres with learning ability and automatic intelligent generating of NC programs on the bases of a neural network, which is built-in into a CNC unit as special device. The device performs intelligent and completely automatically the NC part programs only on the bases of 2D, 2,5D or 3D computer model of prismatic part. Intervention of the operator is not needed. The neural network for milling, drilling, reaming, threading and operations alike has learned to generate NC programs in the learning module, which is a part of intelligent CAD/CAM system.
A prospective study on buprenorphine use during pregnancy: effects on maternal and neonatal outcome (2007)

The pregnancies and deliveries of buprenorphine-using women were uneventful, but severe NAS and need for morphine replacement therapy was seen in 57% of the buprenorphine-exposed newborns. A high number of sudden infant deaths occurred.
Solubility of Sodium Azide and Alpha-Lead Azide. (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolubility of Sodium Azide and Alpha-Lead Azide.E. Lieber, C. N. R. Rao, H. E. Dingle, and J. TeetsovCite this: J. Chem. Eng. Data 1966, 11, 1, 105Publication Date (Print):January 1, 1966Publication History Published online1 May 2002Published inissue 1 January 1966https://pubs.acs.org/doi/10.1021/je60028a030https://doi.org/10.1021/je60028a030research-articleACS PublicationsRequest reuse permissionsArticle Views2331Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ChemInform Abstract: Structure—Activity Relationship Studies of CNS Agents. Part 38. Novel 1,4‐Benzoxazin‐3(4H)‐one, 1,2‐Benzoxazolin‐3‐one, and 1,3‐Benzoxazolin‐2,4‐dione Arylpiperazine Derivatives with Different 5‐HT1A and Antagonistic 5‐HT2A Activities. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.