gebhart/patrepeval huggingface dataset:
Differential Cytotoxic Activity of a Novel Palladium-Based Compound on Prostate Cell Lines, Primary Prostate Epithelial Cells and Prostate Stem Cells (2013)

The outcome for patients with advanced metastatic and recurrent prostate cancer is still poor. Therefore, new chemotherapeutics are required, especially for killing cancer stem cells that are thought to be responsible for disease recurrence. In this study, we screened the effect of a novel palladium-based anticancer agent (Pd complex) against six different prostate cancer cell lines, and primary cultures from seven Gleason 6/7 prostate cancer, three Gleason 8/9 prostate cancer and four benign prostate hyperplasia patient samples, as well as cancer stem cells selected from primary cultures. MTT and ATP viability assays were used to assess cell growth and flow cytometry to assess cell cycle status. In addition, immunofluorescence was used to detect γH2AX nuclear foci, indicative of DNA damage, and Western blotting to assess the induction of apoptosis and autophagy. The Pd complex showed a powerful growth-inhibitory effect against both cell lines and primary cultures. More importantly, it successfully reduced the viability of cancer stem cells as first reported in this study. The Pd complex induced DNA damage and differentially induced evidence of cell death, as well as autophagy. In conclusion, this novel agent may be promising for use against the bulk of the tumour cell population as well as the prostate cancer stem cells, which are thought to be responsible for the resistance of metastatic prostate cancer to chemotherapy. This study also indicates that the combined use of the Pd complex with an autophagy modulator may be a more promising approach to treat prostate cancer. In addition, the differential effects observed between cell lines and primary cells emphasise the importance of the model used to test novel drugs including its genetic background, and indeed the necessity of using cells cultured from patient samples.
[Systematic approach to the analysis of borderline neuro- psychological disorders in oncological practice]. (1991)

To study syndrome formation in the course of the development of neuropsychic disorders in oncological practice, a total systems approach including an original model of psychosomatic correlations was used. Two groups of patients, namely of those suffering from the cancerophobic syndrome without any real oncologic pathology and of those with neuropsychic diseases that developed because of an oncological disease are compared. Analysis is made of the hierarchy and mechanism of interaction of the three factors mainly responsible for the syndrome formation: ++somato-organic, constitutional typological and ++psycho-sociogenic depending on the character and stage of disease. The authors indicate areas where the approach may find practical application: diagnosis, the design of prognosis, and pathogenetic therapy of the neuropsychic disorders under consideration.
MicroRNA‐205–directed transcriptional activation of tumor suppressor genes in prostate cancer (2010)

In this study, a new function for miR-205 was identified that specifically activated tumor suppressor genes by targeting specific sites in their promoters. These results corroborate a newly identified function that miRNAs have in regulating gene expression at the transcriptional level. The specific activation of tumor suppressor genes (eg, IL24, IL32) or other dysregulated genes by miRNA may contribute to a novel therapeutic approach for the treatment of prostate cancer.
Evolving role of positron emission tomography ( PET ) in urological malignancy (2014)

We present a review on the increasing indications for the use of positron emission tomography ( PET ) in uro‐oncology. In this review we describe the details of the different types of PET scans, indications for requesting PET scans in specific urological malignancy and the interpretation of the results.
Scintillator Geometrical Considerations for Detectors Based on Hexagonal SiPMs (2023)

A truncated icosahedron system with hexagonal detectors has been previously proposed as an approach to the ideal spherical PET scanner. In this work, we explore by Monte Carlo simulations, the role of hexagonal scintillator crystals in terms of light yield, scintillation pulse decay time and energy resolution by comparison with three geometries: square and triangular prisms and cylinder. The relevance of the reflector type (diffuse and specular) and finish (polished and rough) of the scintillation borders was also considered. The light yield for the hexagon is higher by approximately 2% and 4% depending on the finish and reflector type in comparison to the square. The energy resolution is between 0.2% and 1% better for the hexagon. Polished walls with specular reflector have the finest energy resolution. The difference in the pulse decay time among geometries is not determining. The light yield and energy resolution were validated experimentally for rough walls and diffuse reflector. A hexagonal scintillation array of 181 crystals of 1.25 mm of edge was finally manufactured. The flood field image read with four multiplexing channels is presented. The detector offers an excellent crystal identification with a mean peak-to-valley ratio over 13 and an energy resolution of 11.5%.
Iconography : MRI measurement of liver fat content predicts the metabolic syndrome (2013)

Diabetes & Metabolism - In Press.Proof corrected by the author Available online since jeudi 21 mars 2013
Pilot study on longitudinal change in pancreatic proton density fat fraction during a weight‐loss surgery program in adults with obesity (2019)

2 Technical Efficacy Stage: 1 J. Magn. Reson. Imaging 2019;50:1092-1102.
Prototype infrared optical sensor and solar cell made of β-FeSi 2 thin film (2003)

A prototype infrared optical sensor has been fabricated by using a 0.21 &#956;m-thick &#946;-iron disilicide (&#946;-FeSi<sub>2</sub>) thin film prepared by reactive deposition epitaxy (RDE) on an n-type (100) Si substrate (&#961; approximately 1.5 &#937;cm). Manganese ions (Mn<sup>+</sup>) were implanted into the &#946;-FeSi<sub>2</sub> thin film as p-type dopants with a total dose of 5.5 x 10<sup>18</sup> cm<sup>-3</sup>. Al and AuSb thin films were metallized on &#946;-FeSi<sub>2</sub> and Si surfaces respectively as electrodes. A circle area of the FeSi<sub>2</sub> film was left naked as the illumination window. The good diode characteristic confirmed the high quality of the pn junction. The spectroscopic spectrum indicated a clear photoresponse at room temperature. As evaluated by a standard solar simulator, the device provided an open-circuit voltage of <i>v</i><sub>oc</sub> = 261 mV and a short-circuit current density of <i>J</i><sub>sc</sub> = 3.1 mA/cm<sup>2</sup>, suggesting a large potential of such devices in solar energy conversion. Rutherford backscattering spectroscopy (RBS) measurements found a large volume of oxygen in the surface of the &#946;-FeSi<sub>2</sub> thin film and severe Fe/Si interdiffusion at the silicide-Si interface. These unwanted effects may be responsible for the unideal device performance. Methods to solve these problems are discussed including a proposal of an all-iron-silicide structure.
Quantification of Magnaporthe grisea During Infection of Rice Plants Using Real-Time Polymerase Chain Reaction and Northern Blot/Phosphoimaging Analyses (2002)

Rice blast, caused by Magnaporthe grisea, is a serious fungal disease of rice worldwide. Currently, evaluation of the fungal pathogenicity and host resistance is mainly based on a disease rating or measurement of blast lesion number and size. However, these methods only provide visual estimation rather than accurate measurement of fungal growth in rice plants. In this study, DNA-based real-time polymerase chain reaction (PCR) and RNA-based northern blot/phosphoimaging analyses were evaluated to quantify M. grisea. Both methods were sensitive, specific, and reproducible and could accurately measure the relative growth and absolute biomass of M. grisea. The real-time PCR analysis showed that the growth of M. grisea in seedling leaves of susceptible cultivars (M201 and Wells) was ≈46 to 80 times higher than that of a resistant cultivar (Drew) at 4 and 6 days after inoculation. The data obtained from the real-time PCR assays also were consistent with that from northern blot/ phosphoimaging analysis. However, the real-time PCR approach was much faster and more convenient in most cases. Therefore, it is an excellent tool for in planta quantification of M. grisea and can be used for reliable assessment of fungal pathogenicity and host resistance
RESCAN: an actinic lensless microscope for defect inspection of EUV reticles (2017)

Actinic mask defect inspection is an essential process step for the implementation of EUV Lithography in high-volume manufacturing. The main challenges for any mask defect inspection platform are resolution, sensitivity, and throughput. The reflective-mode EUV mask scanning lensless imaging microscope (RESCAN) is being developed to provide actinic patterned mask inspection capabilities for defects and patterns with high resolution and high throughput, for node 7 and beyond. Namely, the first goal of the RESCAN project is to develop a tool capable of inspecting an EUV reticle in about 7 hours and detect mask defects down to a size of 10 nm. The lensless imaging concept allows to overcome the resolution limitations due to the numerical aperture (NA) and lens aberrations of conventional actinic mask imaging systems. With the increasing availability of computational power and the refinement of iterative phase reconstruction algorithms, lensless imaging became a powerful tool to synthesize the complex amplitude of the actinic aerial image providing us also with extremely valuable information about phase and mask 3D effects. Here, we present a brief description of the current prototype of the RESCAN platform and illustrate a few experimental examples of programmed defect detection.
Complete cDNA and Deduced Amino Acid Sequence of the Chaperonin Containing T-Complex Polypeptide 1 (CCT) Delta Subunit from Aedes triseriatus Mosquitoes (2001)

The chaperonin containing t-complex polypeptide 1 (CCT) assists in the ATP-dependent folding and assembly of newly translated actin and tubulin in the eukaryotic cytosol. CCT is composed of eight different subunits, each encoded by an independent gene. In this report, we used RT-PCR amplification and 5'- and 3'-rapid amplification of cDNA ends (RACE) to determine the complete cDNA sequence of the CCT delta subunit from Aedes triseriatus mosquitoes. The CCT delta cDNA is 1936 nucleotides in length and encodes a putative 533 amino acid protein with a calculated molecular mass of 57,179 daltons and pI of 7.15. Hydrophobic residues comprise 39.8% of the amino acid sequence and putative motifs for ATP-binding and ATPase-activity are present. The amino acid sequence displays strong sequence similarity to Drosophila melanogaster (92%), human (85%), puffer fish (84%) and mouse (84%) counterparts. CCT delta mRNA was detected in both biosynthetically active (embryonating) and dormant (diapausing) Ae. triseriatus embryos by RT-PCR analysis.
Flachdecken in Elementbauweise mit Gitterträgern (2014)

Abstract Flachdecken werden wirtschaftlich aus vorgefertigten Stahlbetonplatten und einer aufbetonierten Ortbetonschicht hergestellt. Das Tragverhalten dieser Elementdecken mit Gitterträgern ist ähnlich dem von Ortbetondecken. Bei der Bemessung und Konstruktion von Elementdecken sind jedoch einige Besonderheiten zu beachten. Der Eurocode 2 mit zugehörigem nationalem Anhang [ 1 ] enthält Regelungen hierzu. Als Durchstanz‐ und Verbundbewehrung kommen jedoch Bewehrungssysteme zur Anwendung, welche auf der Grundlage von nationalen oder europäischen Zulassungen bemessen werden. Die erforderlichen Nachweise im Durchstanzbereich von Flachdecken werden für unterschiedliche Systeme zusammengestellt und erläutert. Flat Slabs built as Semi‐Precast Slabs with Lattice Girders. Advice to application according to Eurocode 2 Flat slabs are economically made of precast slabs with insitu topping. The load bearing behaviour of these semi‐precast slabs with lattice girders is similar to in situ concrete slabs. Eurocode 2 together with the German annex [ 1 ] gives advice for that. The used punching shear reinforcement and composite reinforcement have to be designed according to national or European technical approvals. The necessary proofs in case of flat slabs are consolidated and explained.
<title>General framework for infrared sensor modeling</title> (1998)

To generate realistic synthetic IR images, required for training in mission rehearsal simulators, image acquisition by IR sensors must be reproduced. In this paper, we propose a general framework for IR sensor modeling which provides a physical basis for describing the geometric and radiometric relationship between the points in the observed scene and the corresponding pixels on the IR sensor output image. This framework is based on the combination of current camera models and draws upon both post-processing and ray tracing techniques. It thus offers more capabilities than standard IR sensor model structures based only on post-processing techniques: better accordance with sensor physics, higher modularity, more accurate sampling, computations suitable for parallelization and connection with any rendering algorithm. The framework enables development of modeling algorithms for each component of the IR image chain (optics, scanner, detector, electronics, signal and image processing) to match the system technology and the desired precision. The IR sensor model developed from this structure allows simulation of a wide range of technologies including staring and scanning systems based on thermal and photon detectors. It can also account for the variations in many physical magnitudes through spatial, spectral and temporal dimensions.
[Clinical effect of a cephalosporin derivative, cefotiam, on otorhinolaryngologic infections]. (1983)

CTM was administered at dose levels of 1 to 3 g a day to 77 cases of otorhinolaryngological infections, and the following results were obtained: The effect of the drug was determined in 75 cases. The responders were 3 out of 5 (60.0%) in acute suppurative otitis media, 4 out of 11 (36.4%) in chronic suppurative otitis media, 39 out of 43 (90.7%) in tonsillitis and peritonsillar abscess and 12 out of 16 (75.0%) in other diseases, a total of 58 out of 75 cases (77.3%). The bacteriological effect of CTM was evaluated in 53 cases, and bacterial eradication was demonstrated in 41 cases (77.4%). Also, its antibacterial potency was 2 to 4 times superior in comparison to that of CEZ against isolated bacteria in which MICs were measurable. Side effects which were neither severe nor specific were recognized in 3 out of 77 cases (3.9%). In the cases with abnormal laboratory values, none was determinable to be attributed to CTM.
A novel hemostatic powder for upper gastrointestinal bleeding: a multicenter study (the “GRAPHE” registry) (2016)

ClinicalTrials.gov (NCT02595853).
The mechanism of influence of polyvinyl alcohol (9 kDa) on the formation of ice crystals in aqueous solutions (2022)

Preventing crystallization of the liquid phase during freeze-thawing of cells is one of the main problems that need to be solved for the successful preservation of biomaterial at low temperatures. One highly effective recrystallization inhibitor is polyvinyl alcohol (PVA). However, the mechanisms of its cryoprotective effect have not been finally elucidated. In particular, it is not clear which structural features contribute to the realization of the antirecrystallization properties of PVA in the region of its cryoprotective concentrations. The influence of PVA on solvent crystallization and structural rearrangements of associations of PVA molecules in phosphate-buffered saline (PBS) was experimentally investigated. Solutions of PVA (molecular weight 9 kDa) in PBS were studied by cryomicroscopy and fluorescence spectroscopy methods. It was shown that molecular associations of PVA in PBS undergo a rearrangement of about 0.5−1 wt%, which is accompanied by a change in their size and hydrophilic-hydrophobic properties. PVA also changes the morphological structure of ice upon cooling and prevents crystallization upon heating. It is suggested that the mechanism of the antirecrystallization activity of PVA may be due to the formation of its complexes with the surface of ice crystals.
Genomic patterns of structural variation among diverse genotypes of Sorghum bicolor and a potential role for deletions in local adaptation (2021)

Genomic structural mutations, especially deletions, are an important source of variation in many species and can play key roles in phenotypic diversification and evolution. Previous work in many plant species has identified multiple instances of structural variations (SVs) occurring in or near genes related to stress response and disease resistance, suggesting a possible role for SVs in local adaptation. Sorghum [Sorghum bicolor (L.) Moench] is one of the most widely grown cereal crops in the world. It has been adapted to an array of different climates as well as bred for multiple purposes, resulting in a striking phenotypic diversity. In this study, we identified genome-wide SVs in the Biomass Association Panel, a collection of 347 diverse sorghum genotypes collected from multiple countries and continents. Using Illumina-based, short-read whole-genome resequencing data from every genotype, we found a total of 24,648 SVs, including 22,359 deletions. The global site frequency spectrum of deletions and other types of SVs fit a model of neutral evolution, suggesting that the majority of these mutations were not under any types of selection. Clustering results based on single nucleotide polymorphisms separated the genotypes into eight clusters which largely corresponded with geographic origins, with many of the large deletions we uncovered being unique to a single cluster. Even though most deletions appeared to be neutral, a handful of cluster-specific deletions were found in genes related to biotic and abiotic stress responses, supporting the possibility that at least some of these deletions contribute to local adaptation in sorghum.
On constructing secret sharing schemes (2002)

A secret sharing scheme is a method which allows a secret to be shared among a finite set of participants in such a way that only qualified subsets of participants can recover it. A secret sharing scheme is called perfect if unqualified subsets of participants obtain no information about the secret. The authors propose an efficient construction of perfect secret sharing schemes for the access structures consisting of the closure of a graph where a vertex denotes a participant and an edge denotes a minimal qualified pairs of participants. The information rate of the scheme is at least 1/(2|P|), where P denotes the set of the participants, which is better than O(1/|P|/sup 2/) of existing schemes used for graph-based access structures. The authors also present an application of the scheme to the reduction of storage and computation loads on the key distribution server in a secure network.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Optical properties of submicrometer-size silver spheroids formed on a graphite substrate (1990)

Oblate spheroidal particles of silver have been fabricated on graphite substrates with an additional silicon dioxide separation of the particle film from the substrate. The particles exhibit well-resolved resonances in absorption spectra. These resonances are affected by the variation of the thickness of the SiO2 separation. Calculations based upon a nonretarded, dielectric interaction for this configuration are found to be in agreement with experimental observations.
Development of multiple-surface optical elements for road lighting (2017)

The development of LED secondary optics for road illumination is quite a challenging problem. Optical elements developed for this kind of application should have maximal efficiency, provide high luminance and illuminance uniformity, and meet many other specific requirements. Here, we demonstrate that the usage of the supporting quadric method modification enables generating free-form optical solution satisfying all these requirements perfectly. As an example, two optical elements for different roadway types are computed, manufactured by injection molding, and then measured in a photometry bench. Experimental data demonstrate that the obtained light distributions meet ME1 class requirements of EN 13201 standard. The obtained directivity patterns are universal and provide high performance with different configurations of luminaires' arrangement: the ratio of pole altitude to distance can vary from 2.5 up to 3.6.
Helical Waveguide Sensor for Fluid-Level Sensing Using L(0, 1), T(0, 1), and F(1, 1) Wave Modes Simultaneously (2023)

This article studies an ultrasonic waveguide sensor using thin stainless-steel wire with helical configurations for measuring various fluid levels. The fundamental longitudinal <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">${L}$ </tex-math></inline-formula> (0, 1), torsional <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">${T}$ </tex-math></inline-formula> (0, 1), and flexural <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">${F}$ </tex-math></inline-formula> (1, 1) wave modes were used simultaneously through the waveguide using a shear transducer. Initially, a finite element model (FEM) was used to study all three wave modes’ behavior when we immersed the waveguide in an air medium and immersed it at different fluid levels. Similarly, we experimentally measured the various fluid levels using water, petrol, and glycerin. The fluid-level measurements were based on the drop in amplitude and the change in time of flight ( <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\delta $ </tex-math></inline-formula> TOF) of all three wave modes. Multiple experiment trials (T1, T2, and T3) were conducted for each case to ensure the repeatability of the helical sensor. The sensor’s error analysis was studied using all three wave modes, and the average error was less than 2.5%. We identified better sensitivity using the <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">${F}$ </tex-math></inline-formula> (1, 1) wave mode for fluid-level measurement compared to the other two wave modes. Minute fluid-level measurement experiments were conducted for every 0.5-mm increment of the fluid level using the <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">${F}$ </tex-math></inline-formula> (1, 1) wave mode. This method can be used in highly flammable or hazardous regions, such as fuel tank level sensing, temperature, and viscosity measurement simultaneously, especially in oil and gas industries.