gebhart/patrepeval huggingface dataset:
Model for Power Cycling lifetime of IGBT Modules - various factors influencing lifetime (2008)

A large number of power cycling data from different IGBT module generations and test conditions have been evaluated. Multiple regression with respect to the variables temperature swing DeltaTJ, TJ, power-on-time (ton), chip thickness, bonding technology, diameter (D) of bonding wire, current per wire bond (I) and package type was performed. It provided parameters for a new empirical model describing number of power cycles (Nf) in relation to these variables. For a fixed module technology and blocking voltage class, the set of variables have been restricted to DeltaTJ, TJ, ton and I as the factors influencing the number of cycles to failure. The model is used to estimate the power cycling capability for the new generation of 1200V-IGBT4 Modules, which are rated up to a junction temperature of 150deg C in operation.
Processing and Linking Audio Events in Large Multimedia Archives: The EU inEvent Project (2013)

In the inEvent EU project [1], we aim at structuring, retrieving, and sharing large archives of networked, and dynamically changing, multimedia recordings, mainly consisting of meetings, videoconferences, and lectures. More specifically, we are developing an integrated system that performs audiovisual processing of multimedia recordings, and labels them in terms of interconnected “hyper-events ” (a notion inspired from hyper-texts). Each hyper-event is composed of simpler facets, including audio-video recordings and metadata, which are then easier to search, retrieve and share. In the present paper, we mainly cover the audio processing aspects of the system, including speech recognition, speaker diarization and linking (across recordings), the use of these features for hyper-event indexing and recommendation, and the search portal. We present initial results for feature extraction from lecture recordings using the TED talks. Index Terms: Networked multimedia events; audio processing: speech recognition; speaker diarization and linking; multimedia indexing and searching; hyper-events. 1.
Considerations on the tendency for calcification in meningiomas. (1996)

Calcifications in meningotheliomatous and fibromatous meningiomas were demonstrated after maceration under the scanning electron microscope and by pluck preparation. In five predominantly meningotheliomatous and five fibromatous meningiomas vascular features were studied after injection of Indian ink. The influx of calcium into the tumor parenchyma is thought to be related to long vessel loops and parallel coursing vessels which act as a countercurrent multiplication system similar to the loops of Henle in the kidney. Abruptly changing of diameter of vessels reduces the flow rate and enhances the transport of ions across vessels walls. Furthermore, the fine structure of endothelium favors the escape of ions into vessel walls and into parenchyma. Possible consequences of an intratumoral Ca overload are briefly discussed.
Quand les mots s'organisent en réseaux (2010)

Lexical structure of languages is similar to social structures in some respect, as both can be described by networks called 'small world graphs'. This paper presents methods that had been recently used to model these structures: geometrical representations of the graphs in which each word is represented by a region in a semantic space.
Dietary glycemic index, glycemic load, and renal cancer risk: findings from prostate, lung, colorectal, and ovarian cancer trial (2023)

In summary, findings of this large-scale prospective cohort study suggested that dietary GI may be associated with the risk of renal cancer. If confirmed in other populations and settings, dietary GI could be considered as a modifiable risk factor for renal cancer prevention.
Sociotropy, autonomy, and dysphoric emotional responses to specific classes of stress: A psychophysiological evaluation. (1996)

The aim of this study was to assess the ability of trait measures of sociotropy and autonomy to predict immediate emotional responses to imagery conditions depicting social rejection and achievement failure. Emotional responses were assessed by self-report techniques and by 2 putative psychophysiological measures of dysphoric mood: heart rate and facial muscle activity. Undergraduate volunteers (N = 100) were assessed for sociotropic and autonomous traits, general levels of depression, and sensory imagery ability, before performing a series of imagery trials depicting neutral and stressful (social rejection and achievement failure) scenes. Results provided support for the role of sociotropy as a vulnerability factor to dysphoric response to social rejection and to a lesser degree for achievement failure, but there was no support for autonomy as a vulnerability factor for either type of stressful script.
PAPER 129: USE OF THE LENKE CLASSIFICATION FOR DOUBLE THORACIC CURVES (2010)

Purpose: The Lenke classification has established criteria which designate the proximal thoracic (PT) curve as structural (Lenke 2). However, this classification may overestimate the necessity to include the proximal thoracic curve in the fusion construct. The objective of this study was to compare the incidence of fusing the PT curve for true Lenke 2 curve patterns, comparing a time period when the classification was not utilized and when it was first used. Method: A retrospective review of a consecutive series of patients with adolescent idiopathic scoliosis (AIS) at a single institution from 1996–2000 (early group) and from 2002–2004 (late group) were reviewed. The curves were all classified by the Lenke classification retrospectively. Patients were also grouped into those who have had inclusion of the PT curve (+PT fusion) and those who did not (−PT fusion). Results: There were 44 in the early group and 33 in the late group. There were no differences in the early and late groups with respect to age (14.3 vs. 14.4yrs), gender (79.5% vs. 69.7% female), BMI (21.7 vs. 22.4kg/cm2), the preoperative PT magnitude (40.0° vs. 38.6°), curve flexibility (16.0% vs. 14.5%), the main thoracic (MT) magnitude (63.4° vs. 62.7°), T1 tilt (7.3° vs. 5.2°), pre-operative clavicle angle (1.0° vs. −0.2°), and preoperative shoulder height (1.2 vs. −0.8mm. The early group had fusion of the PT less often (36% vs. 57%)(p Conclusion: The application of the Lenke classification system for AIS increases the likelihood of instrumenting a PT curve resulting in improved postoperative PT curve magnitude. However, similar shoulder balance, T1 tilt and clavicle angle were seen compared between groups. The classification system should be used to guide decision making, however, other parameters should be evaluated when deciding when to instrument a PT curve.
Description of novel capsule biosynthesis loci of Campylobacter jejuni clinical isolates from South and South-East Asia (2023)

Campylobacter jejuni is a major cause of bacterial diarrhea worldwide and associated with numerous sequela, including Guillain-Barré Syndrome, inflammatory bowel disease, reactive arthritis, and irritable bowel syndrome. C. jejuni is unusual for an intestinal pathogen in its ability to coat its surface with a polysaccharide capsule (CPS). The genes responsible for the biosynthesis of the phase variable CPS is located in the hypervariable region of C. jejuni genome which has been used to develop multiplex PCR to classify CPS types based on the Penner serotypes. However, there still are non-typable CPS C. jejuni by the current multiplex PCR scheme. The application of the next generation sequencing and whole genome analysis software were used for the identification of novel capsule biosynthesis of C. jejuni isolates. Unique PCR primers were designed to identify these new capsule biosynthesis loci. The designed primers sets were combined in a new multiplex mix called epsilon. The unique sequences provide an additional information of the biosynthesis loci responsible for some of the common CPS sugars/residues such as heptose, deoxtyheptose and MeOPN among C. jejuni in this new group of CPS multiplex assay. This new primer complements the current C. jejuni multiplex capsule typing system and will help in identifying previously untypeable capsule locus of C. jejuni isolates.
Comparison of PSA, FDG-PET, and Prostate Cancer Working Group 2 (PCWG2) criteria to interpret apparent progression on first post-treatment bone scan. (2012)

20 Background: The risk of prematurely discontinuing effective therapy in patients with metastatic castrate resistant prostate cancer (mCRPC) because of apparent initial progression on bone scan has repercussions for drug development and clinical practice. We evaluated three methods to distinguish disease progression (POD) from non-progressive bone disease or flare response. Methods: The dataset was comprised of men with mCRPC enrolled in contemporary clinical trials using AR-directed or targeted therapy. To be included, a worsened bone scan (increased size, intensity, or number of lesions) at the time of initial follow-up at 8-12 wks (FU1), a concurrently performed FDG-PET and PSA, and a second follow-up bone scan (FU2) &gt; 6 wks after FU1 were required. Pts were evaluated by three methods: 1) PSA-guided approach: POD was defined as a PSA increase &gt;25% from baseline at FU1; for non-progressors, a special category was created for flare response defined as a PSA decline &gt;50% and a FU2 bone scan documenting stability/improvement; 2) FDG-PET approach: POD was defined as a new bone lesion or increase in SUV &gt;10% at FU1; 3) Bone scan only approach: POD was defined by PCWG2 requiring 2 new bone scan lesions at FU1 and 2 additional lesions at FU2. Results: 66 pts registered to trials conducted between 2007-2011 were examined; 38/66 (57.6%) pts had a worsened bone scan at FU1, 23 of whom had a FU2 bone scan and were considered evaluable for this analysis. Conclusions: Over half of mCRPC pts have a worsening bone scan during the first three months of therapy. PCWG2 controls for flare without use of PSA, confirms radiographic POD, and maintains pts on study longer than use of early post-treatment PSA changes. FDG-PET at first assessment appears to identify an identical percentage of progressors as PCWG2 did at the second assessment. PCWG2 is undergoing prospective validation in phase III trials; the use of FDG PET as an early response biomarker is currently under investigation. [Table: see text]
Inter-Component Transform for Color Video Coding (2019)

In natural digital images and videos, correlations between color components can be observed. These correlations can be exploited to achieve additional coding gain in modern block-based hybrid video coding. To this end, we propose the use of a block-wise, rotational inter-component transform (ICT) applied to the two residual chroma signals that result from conventional intra or inter-picture prediction. Different ICT parameterizations in terms of number and quantization of the rotational angles as well as resulting components signaled in the coded bitstream are investigated. An implementation into the currently developed Versatile Video Coding (VVC) reference software provides average bitrate savings of up to 0.7% (All Intra configuration) with negligible increases in implementation complexity and runtime. Our proposal has been adopted into the VVC draft specification text.
Planar and tilted uniform alignment of liquid crystals by plasma-treated substrates (2004)

We describe a new aligning technique that yields uniform planar or tilted orientation of a nematic liquid crystal at different organic and inorganic substrates. The method is based on the oblique irradiation of an aligning substrate with a partially collimated flux of accelerated plasma. The sheet-like plasma flux is produced by an anode layer thruster with a race track geometry of the discharge channel. For liquid crystals with a positive dielectric anisotropy the technique produces two modes of uniform alignment: (1) with the easy axis in the incident plane of the plasma beam; (2) with the easy axis perpendicular to the plane of incidence. Mode 1 transforms into mode 2 as the irradiation dose increases. In mode 1, the pretilt angle can be controlled by changing the parameters of irradiation such as incidence angle, current density and particle energy. In mode 2, the pretilt angle is zero (planar alignment). The azimuthal anchoring coefficient is relatively weak (W a∼10−6 J m−2) for the first type of alignment and strong (W a≥10−4 J m−2, comparable to rubbed polymer substrates) for the second type. The two-mode alignment feature can be used to control alignment properties and to create alignment patterns. The method is free from the usual shortcomings of the traditional rubbing technique. We discuss possible mechanisms of the two-mode alignment and show that plasma-induced modifications of the substrate topography might be an important factor in liquid crystal alignment.
Optimal Cyclic (r, δ) Locally Repairable Codes With r + δ - 1 = (q+1)/4 (2021)

Locally repairable codes (LRCs), due to the local erasure-correcting property, have been widely used in distributed storage systems. In this paper, we construct cyclic (r, δ) LRCs ((r, δ) CLRCs) which are optimal according to the Singleton-like bound. The locality of the new CLRCs satisfies that $r + \delta - 1 = \frac{{q + 1}}{4}$. This is different from those of CLRCs obtained by Qian and Zhang in 2020 which are $r + \delta - 1 = q + 1{\text{ and }}r + \delta - 1 = \frac{{q + 1}}{2}$. Then the parameters of our CLRCs are new.
Photochemistry (1998)

Compiled by teams of leading authorities this Specialist Periodical Report on Photochemistry aims to provide an annual review of photo-induced processes.
Decentralized Fuzzy Output Feedback Controller for Nonlinear Interconnected System with Time Delay (2008)

본 논문은 시간 지연을 가지는 비선형 상호 결합 시스템에 대한 분산 퍼지 출력 궤환 제어기를 제시한다. Takagi-Sugeno (T-S) 퍼지 모델링을 통하여 비선형 상호 결합 시스템을 퍼지 모델로 표현한다. 상호 결합 시스템의 하위 퍼지 시스템을 안정화 시킬 수 있는 분산 출력 궤한 제어기를 설계한다. 폐루프 하위 시스템들의 안정도 조건을 선형 행렬 부등식으로 나타내고, 부등식을 이용하여 제어기의 이득값을 구한다. 모의실험을 통하여 시간 지연이 있는 비선형 상호 결합 시스템에 대한 분산 퍼지 출력 궤한 제어기의 효용성을 평가한다. In this paper, a decentralized fuzzy output feedback controller for nonlinear interconnected systems with time delay is proposed. The nonlinear interconnected system is represented to fuzzy system using Takagi-Sugeno (T-S) fuzzy model. The decentralized output feedback controller is designed(or stability of subsystems of the fuzzy interconnected system. The stable condition of the closed-loop subsystem is represented to the linear matrix inequality (LMI) form and control gain is obtained by LMI. An example is given to show the verification discussed throughout the paper.
A Prospective, Randomized, Masked, and Placebo-Controlled Efficacy Study of Intraarticular Allogeneic Adipose Stem Cells for the Treatment of Osteoarthritis in Dogs (2016)

Osteoarthritis (OA) is a degenerative joint disease with a high prevalence in dogs. Mesenchymal stem cells (MSCs) have been used to treat humans, dogs, and horses with OA. This report describes a prospective, randomized, blinded, and placebo-controlled clinical efficacy study of intraarticular allogeneic adipose stem cells for the treatment of dogs with OA. Health assessments and measurements of pain and activity impairment were performed at baseline and at selected time points through day 60. The primary outcome variable was the owner Client-Specific Outcome Measurement (CSOM) and secondary measures included veterinary pain on manipulation, veterinary global score, and owner global score. The dogs were treated with either a saline placebo or a single dose of allogeneic adipose-derived MSCs in either one or two joints. Seventy-four dogs were statistically analyzed for efficacy outcomes. Success in the primary outcome variable, CSOM, was statistically improved in the treated dogs compared to the placebo dogs (79.2 versus 55.4%, <i>p</i> = 0.029). The veterinary pain on manipulation score (92.8 versus 50.2%, <i>p</i> = 0.017) and the veterinary global score (86.9 versus 30.8%, <i>p</i> = 0.009) were both statistically improved in treated dogs compared to placebo. There was no detected significant difference between treated and placebo dogs in the incidence of adverse events or negative health findings. Allogeneic adipose-derived stem cell treatment was shown to be efficacious compared to placebo. This large study of dogs also provides valuable animal clinical safety and efficacy outcome data to our colleagues developing human stem cell therapy.
Editorial: Advances in Cell and Gene Therapy in Treating Neural Diseases (2021)

EDITORIAL article Front. Cell. Neurosci., 15 November 2021 | https://doi.org/10.3389/fncel.2021.794010
Polyelectrolytes : science and technology (1993)

Aims to provide in-depth coverage of recent advances in all important areas of polyelectrolyte research and applications. Topics covered in this text include scaling theory, dynamic light scattering, neutron scattering, biopolymers and ionomers.
Machine learning for transient discovery in Pan-STARRS1 difference imaging (2015)

Efficient identification and follow-up of astronomical transients is hindered by the need for humans to manually select promising candidates from data streams that contain many false positives. These artefacts arise in the difference images that are produced by most major ground-based time-domain surveys with large format CCD cameras. This dependence on humans to reject bogus detections is unsustainable for next generation all-sky surveys and significant effort is now being invested to solve the problem computationally. In this paper, we explore a simple machine learning approach to real-bogus classification by constructing a training set from the image data of 32 000 real astrophysical transients and bogus detections from the Pan-STARRS1 Medium Deep Survey. We derive our feature representation from the pixel intensity values of a 20 20 pixel stamp around the centre of the candidates. This differs from previous work in that it works directly on the pixels rather than catalogued domain knowledge for feature design or selection. Three machine learning algorithms are trained (artificial neural networks, support vector machines and random forests) and their performances are tested on a held-out subset of 25 per cent of the training data. We find the best results from the random forest classifier and demonstrate that by accepting a false positive rate of 1 per cent, the classifier initially suggests a missed detection rate of around 10 per cent. However, we also find that a combination of bright star variability, nuclear transients and uncertainty in human labelling means that our best estimate of the missed detection rate is approximately 6 per cent.
A Unified Model for Multi-Frequency PPP Ambiguity Resolution and Test Results with Galileo and BeiDou Triple-Frequency Observations (2019)

With the modernization of Global Navigation Satellite System (GNSS), triple- or multi-frequency signals have become available from more and more GNSS satellites. The additional signals are expected to enhance the performance of precise point positioning (PPP) with ambiguity resolution (AR). To deal with the additional signals, we propose a unified modeling strategy for multi-frequency PPP AR based on raw uncombined observations. Based on the unified model, the fractional cycle biases (FCBs) generated from multi-frequency observations can be flexibly used, such as for dual- or triple- frequency PPP AR. Its efficiency is verified with Galileo and BeiDou triple-frequency observations collected from globally distributed MGEX stations. The estimated FCB are assessed with respect to residual distributions and standard deviations. The obtained results indicate good consistency between the input float ambiguities and the generated FCBs. To assess the performance of the triple-frequency PPP AR, 11 days of MGEX data are processed in three-hour sessions. The positional biases in the ambiguity-fixed solutions are significantly reduced compared with the float solutions. The improvements are 49.2%, 38.3%, and 29.6%, respectively, in east/north/up components for positioning with BDS, while the corresponding improvements are 60.0%, 29.0%, and 21.1% for positioning with Galileo. These results confirm the efficiency of the proposed approach, and that the triple-frequency PPP AR can bring an obvious benefit to the ambiguity-float PPP solution.
Triclosan Antagonizes Fluconazole Activity against Candida albicans (2011)

Triclosan is a broad-spectrum antimicrobial compound commonly used in oral hygiene products. Investigation of its activity against Candida albicans showed that triclosan was fungicidal at concentrations of 16 mg/L. However, at subinhibitory concentrations (0.5-2 mg/L), triclosan antagonized the activity of fluconazole. Although triclosan induced CDR1 expression in C. albicans, antagonism was still observed in cdr1Δ and cdr2Δ strains. Triclosan did not affect fluconazole uptake or alter total membrane sterol content, but did induce the expression of FAS1 and FAS2, indicating that its mode of action may involve inhibition of fatty acid synthesis, as it does in prokaryotes. However, FAS2 mutants did not exhibit increased susceptibility to triclosan, and overexpression of both FAS1 and FAS2 alleles did not alter triclosan susceptibility. Unexpectedly, the antagonistic effect was specific for C. albicans under hypha-inducing conditions and was absent in the non-filamentous efg1Δ strain. This antagonism may be due to the membranotropic activity of triclosan and the unique composition of hyphal membranes.
CRISPR-Cas9 mediated one-step disabling of pancreatogenesis in pigs (2017)

Genome editing using programmable nucleases has revolutionized biomedical research. CRISPR-Cas9 mediated zygote genome editing enables high efficient production of knockout animals suitable for studying development and relevant human diseases. Here we report efficient disabling pancreatogenesis in pig embryos via zygotic co-delivery of Cas9 mRNA and dual sgRNAs targeting the PDX1 gene, which when combined with chimeric-competent human pluriopotent stem cells may serve as a suitable platform for the xeno-generation of human tissues and organs in pigs.
Distinct roles of cdk2 and cdc2 in RP-A phosphorylation during the cell cycle (1993)

RP-A is a single-stranded DNA-binding protein, which has been shown to be required for DNA replication using an SV40 model system. The protein has also been shown to be phosphorylated at the G1-S phase transition. Using Xenopus cell-free extracts we have investigated the role of RP-A in nuclear replication and characterized the kinases and conditions that lead to phosphorylation of RP-A during the cell cycle. By immunodepleting RP-A from Xenopus extracts we have shown that RP-A is essential for replication of chromosomal DNA. Our results show that, during S phase, only that RP-A which is associated with nuclei is phosphorylated. Furthermore our results indicate that during S phase RP-A is only phosphorylated when associated with single-stranded DNA. By immunodepleting cdk2 kinase we show that cdk2 kinase is required for the observed phosphorylation of RP-A in nuclei during S phase. However, using purified cdk2 kinase and RP-A we are unable to detect a direct phosphorylation of RP-A by cdk2 kinase. This observation suggests that phosphorylation of DNA-bound RP-A at S phase is carried out by a kinase distinct from cdk2. Consistent with this we find that when single-stranded DNA is added to S phase extracts depleted of cdk2 kinase, RP-A is phosphorylated. Together these results suggest that cdk2 kinase participates in the activation of DNA replication at a stage prior to the binding of RP-A to the initiation complex. In addition to RP-A phosphorylation in S phase, we have also found that at the onset of mitosis RP-A is quantitatively phosphorylated and that phosphorylation is directly mediated by cdc2 kinase. However, at this time during the cell cycle, cdc2-dependent phosphorylation of RP-A is independent of DNA binding. These observations further demonstrate the distinctions between cdk2 and cdc2 kinases.