gebhart/patrepeval huggingface dataset:
Modeling and simulation for parallel hybrid electric vehicle powertrain (2011)

Hybrid Electric Vehicles, HEV, are an attractive opportunity to use new energy sources in road transportation, not only to minimize fuel consumption but also to reduce air pollution. This paper presents a discussion of mathematical modeling, analysis, and simulation of parallel hybrid electric vehicle powertrain system. Theory basis of modeling PHEV powertrain has been analyzed. Using ADVISOR software based on the Matlab/Simulink environment as simulation platform, main models of PHEV powertrain are established. The models are simulated on SP-PHEV2000. The result shows that SP-PHEV2000 excels Santane 2000 GLi in vehicle performance. The model and simulation method are verified reasonable and feasible. These provide reference for PHEV parameter optimization and matching.
Optimization Study for Treatment of Acid Mine Drainage Using Membrane Technology (2010)

The use of membrane technology in the treatment of Acid Mine Drainage (AMD) can result in reduction of chemical usage and sludge production making the treatment process more environmentally friendly. This study deals with the optimization of membrane filtration performance in the treatment of AMD using two nanofiltration (NF) membranes (NF99 and DK) and one reverse osmosis (RO). All membranes were used in various tests treating a model solution at two different concentration levels in order to cover the concentration of actual AMD found in the mining industry. The main parameters which were studied to determine the optimal condition for AMD filtration are pressure, pH, temperature, and flow rate. Pressure and temperature were found to have a considerable influence on flux, while rejection was only slightly influenced by pressure. The feed flow rate had no effect on rejection. The highest flux with moderate rejection was determined for NF99 while RO had the lowest flux but highest rejection. Therefore, NF is preferable for AMD treatment due to lowest energy consumption. The treatment has also been tried on a large scale to check its applicability at a commercial scale. Finally, PHREEQC has been used to determine the scaling risk in the prepared AMD.
Macrophage Differentiation and Function in Atherosclerosis: Opportunities for Therapeutic Intervention? (2012)

The macrophage is exquisitely sensitive to its microenvironment, as demonstrated primarily through in vitro study. Changes in macrophage phenotype and function within the atherosclerotic plaque have profound consequences for plaque biology, including rupture and arterial thrombosis leading to clinical events such as myocardial infarction. We review the evidence for dynamic changes in macrophage numbers and macrophage differentiation within the atherosclerotic plaque microenvironment and discuss potential approaches to target macrophage differentiation for therapeutic benefit in cardiovascular disease.
cAMP is not an important messenger for ADP-induced platelet aggregation (1996)

In rat platelets, basal cAMP level did not vary significantly during ADP-induced aggregation. In the same conditions, no variation in the cAMP content was observed in platelets from rats treated with clopidogrel, whereas ADP-induced aggregation was totally inhibited. ADP decreased cAMP level in control prostacyclin- or forskolin-stimulated platelets whereas, in treated platelets, adenylyl cyclase down-regulation was strongly inhibited. SQ 22536 (500 microM), an inhibitor of adenylyl cyclase, strongly reduced the cAMP content of both control and treated platelets but did not reverse the anti-aggregating activity of clopidogrel, showing that inhibition of ADP-induced adenylyl cyclase down-regulation in treated platelets was not responsible for the anti-aggregating effect of clopidogrel. Similar results were obtained in rabbit platelets. These results therefore demonstrate that cAMP is not an important second messenger for ADP-induced platelet aggregation and suggest that another activating pathway, linked to the low affinity ADP receptor present on the platelet surface might be involved in the aggregation process.
Investigation of the mechanics of rail seat deterioration and methods to improve the abrasion resistance of concrete sleeper rail seats (2014)

A sustained increase in gross rail loads and cumulative freight tonnages on heavy haul railways, as well as increased interest in high- and higher-speed passenger rail development, is placing an increasing demand on railway infrastructure and its components. Rail seat deterioration (RSD) refers to the degradation of the material at the contact interface between the sleeper’s rail seat and the pad that protects the bearing area of the sleeper. RSD continues to be identified as one of the primary factors limiting concrete sleeper service life, particularly in heavy haul operations. This paper includes results from two laboratory experiments that used test setups and protocols and were designed to isolate the abrasion mechanism. The first experiment was used to acquire quantitative and qualitative data related to the frictional properties of rail pad materials sliding on a concrete surface under various normal loads. The second experiment quantified the abrasion resistance of rail seat materials. Results confirmed that abrasion is a feasible RSD mechanism and that the frictional characteristics at the contact interface between the rail pad and concrete rail seat appear to have an impact on the transfer of forces and relative movement, and thus the abrasion mechanism. Also, the abrasion resistance of the rail seat’s surface can be improved by grinding off the top cement paste layer to expose a hard aggregate surface and also by applying an epoxy coating to the surface. Increasing the service life of railway track components will facilitate capacity building on heavy haul, mixed-traffic and passenger railways around the world by reducing maintenance costs and decreasing the demand for maintenance windows.
Regulating myoblast phenotype through biomimetically designed hydrogels. (2006)

The loss or failure of human tissues or organs is a frequent and costly problem in terms of life and economic loss. The limitations of currently available therapies have spurred the creation of a research field entitled Tissue Engineering. Development of advanced biomaterials will play a key role in the success of tissue engineering. This thesis research focuses on designing material scaffolds presenting bioactive molecules with controllable degradation, and understanding how the signaling molecules regulate cellular function. In the first series of experiments, alginate material platforms were developed that incorporated RGD peptides as adhesion ligands while varying the ligand density, ligand affinity, and nanoscale distribution. Increasing ligand density or binding affinity led to a similar enhancement in proliferation of C2C12 cells and human primary myoblasts. The nanoscale distribution of clustered RGD influenced C2C12 cells and human primary myoblasts but proliferation was effected in an opposing manner. To understand how the RGD presentations modulate cellular function, rheological measurements and a FRET technique were further utilized to quantify the extent of receptor-ligand interactions. Higher relative numbers of bonds formed when RGD density and affinity were increased, as assessed by both approaches, and this finding correlated with cell growth rates. This suggested that varying peptide density and affinity may regulate cellular function by altering the number of bonds formed. However, the influence of nanoscale distribution could not be explained by the number of bonds. Secondly, the hypothesis that alginate gel degradation could regulate the function of myoblasts encapsulated in 3-D microenvironment was tested. Development of degradable alginate gels with tunable rates was established by a combination of partial oxidation and bimodal molecular weight distribution. Myoblasts were encapsulated in gels varying in degradation rate. C2C12 cells in degradable gels exhibited lower proliferation, due to exiting the cell cycle to differentiate, as compared to those in non-degradable gels. Mouse primary myoblasts illustrated significantly higher proliferation in degradable gels, while cells in non-degradable gels showed limited proliferation. Subsequent reduction of mechanical properties also influenced myoblast adhesion, proliferation, and differentiation in a 2-D cell culture model. Cells on stiffer gels illustrated higher spreading, proliferation, and differentiation. Altogether, the material developments in this study elucidate how one can acquire specific bioactivity from biomaterials to control desirable cellular functions and to understand these processes. The degradability of scaffolding materials might also be crucial for long-term success of tissue engineering. The principles delineated in these studies may be useful to tailor smart biomaterials that can be applied to many other polymeric systems and tissue types.
Abstract 3573: Protection of Hypothermia-induced Contractile Dysfunction in Mice With Cardiac Specific Expression of Slow Skeletal Troponin I (2009)

Rewarming the intact heart from hypothermia is associated with reduced contractile function, decrease in myofilament response to Ca2, and increased cardiac troponin I (cTnI) phosphorylation. To fur...
Dossier Médical Partagé : stop ou encore ? (2019)

cairn.info/revue-dermato-mag-2019-1-page-45?lang=fr Dcouvrir le sommaire de ce numro, suivre la revue par email, s'abonner... Scannez ce QR Code pour accder la page de ce numro sur Cairn.info. Distribution lectronique Cairn.info pour JLE ditions.Vous avez l'autorisation de reproduire cet article dans les limites des conditions d'utilisation de Cairn.infoou, le cas chant, des conditions gnrales de la licence souscrite par votre tablissement.Dtails et conditions sur cairn.info/copyright.Sauf dispositions lgales contraires, les usages numriques des fins pdagogiques des prsentes ressources sont soumises l'autorisation de l'diteur ou, le cas chant, de l'organisme de gestion collective habilit cet effet.Il en est ainsi notamment en France avec le CFC qui est l'organisme agr en la matire.
Collinear and degenerate polariton pair emission via biexciton‐resonant hyper‐parametric scattering (2015)

Abstract We report on the efficient generation of the collinear and degenerate polariton pair via biexciton‐resonant hyper‐parametric scattering (RHPS) in a CuCl single crystal using the non‐collinear and two‐color excitation method. By using this excitation method, a strong emission peak is observed at one‐half of the biexciton energy ( E bx /2). The strong emission obtained at E bx /2 originates from the collinear and degenerate scattered polariton pair generated through the RHPS process. Furthermore, it is found that the energies of the scattered polaritons are split and deviated from E bx /2, when the energies of the two excitation pulses are changed. We discuss the variation of the scattered polariton energies with changing the energies of the two excitation pulses on the basis of the phase matching condition for the RHPS process. (© 2016 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
Field Application of the Micro Biological Survey Method for a Simple and Effective Assessment of the Microbiological Quality of Water Sources in Developing Countries (2015)

According to the World Health Organization (WHO) guidelines, "safe drinking-water must not represent any significant risk to health over a lifetime of consumption, including different sensitivities that may occur between life stages". Traditional methods of water analysis are usually complex, time consuming and require an appropriately equipped laboratory, specialized personnel and expensive instrumentation. The aim of this work was to apply an alternative method, the Micro Biological Survey (MBS), to analyse for contaminants in drinking water. Preliminary experiments were carried out to demonstrate the linearity and accuracy of the MBS method and to verify the possibility of using the evaluation of total coliforms in 1 mL of water as a sufficient parameter to roughly though accurately determine water microbiological quality. The MBS method was then tested "on field" to assess the microbiological quality of water sources in the city of Douala (Cameroon, Central Africa). Analyses were performed on both dug and drilled wells in different periods of the year. Results confirm that the MBS method appears to be a valid and accurate method to evaluate the microbiological quality of many water sources and it can be of valuable aid in developing countries.
Porównawcza ocena psychologicznych wskaźników jakości życia u dorosłych po korekcji chirurgicznej ubytku przegrody międzyprzedsionkowej i tetralogii Fallota (2005)

Wstep : Wyrazem postepu, ktory osiągnieto w kardiochirurgii i kardiologii, są coraz lepsze wyniki
operacyjne oraz dlugoletnia przezywalnośc pacjentow po korekcji wad wrodzonych serca. Dotychczas
opublikowano niewiele prac oceniających jakośc zycia tej populacji chorych. Celem niniejszego
badania byla ocena i porownanie jakości zycia (QoL) pacjentow operowanych z powodu ubytku
przegrody miedzyprzedsionkowej typu drugiego (ASD II) i tetralogii Fallota (ToF). Decyzje
o wyborze takich chorych podjeto, poniewaz przypuszcza sie, ze wrodzone wady serca o tak
odmiennym przebiegu klinicznym jak ASD i ToF mogą roznie wplywac na QoL pacjentow. 
Material i metody : Do 226 osob (162 K, 64 M) operowanych z powodu ASD II i 60 pacjentow
(24 K, 36 M) po korekcji operacyjnej ToF wyslano wstepne ankiety. Odpowiedź na ankiete
odeslalo 110 chorych (48,3%) po korekcji ASD II w wieku 17-72 lat (śr. 44,7 ± 12,1 roku;
69 K, 41 M) i 42 pacjentow (66,9%) po operacji ToF w wieku 22-61 lat (śr. 39,1 ± 10,2 roku;
20 K, 22 M). Do tych osob wyslano kwestionariusze psychologiczne, na ktore odpowiedzialo
68 chorych z grupy ASD II (śr. wieku 45,7 roku; 51 K, 17 M) oraz 27 pacjentow z grupy ToF
(śr. wieku 39,8 roku; 9 K, 18 M). Czas, ktory uplynąl od operacji, wynosil średnio 11,8 roku.
Do oceny QoL uzyto kwestionariusza jakości zycia SF-36. Wyniki testow porownano miedzy
grupami chorych i odniesiono do grupy kontrolnej osob zdrowych, dobranej pod wzgledem
wieku, plci i wyksztalcenia. 
Wyniki : Nie stwierdzono roznic miedzy QoL pacjentow z grup ASD i ToF. Chorzy po korekcji
ASD II i ToF charakteryzowali sie gorszą ogolną QoL oraz ogolną oceną zdrowia fizycznego
w porownaniu z grupą kontrolną. Miedzy wszystkimi badanymi grupami nie stwierdzono
roznic w ocenie zdrowia mentalnego. 
Wnioski : Miarą skuteczności leczenia operacyjnego wrodzonych wad serca jest nie tylko
wydluzenie zycia, ale rowniez poprawa jego jakości. Jakośc zycia chorych po operacjach kardiochirurgicznych
wydaje sie byc niezalezna od typu rozpoznawanej wrodzonej anomalii serca.
Nawet wady o tak lagodnym przebiegu, jak ASD II mogą wplywac na psychologiczną sfere
zycia pacjentow w odleglych obserwacjach pooperacyjnych. Wysilki lekarzy powinny byc skierowane
na dzialania poprawiające funkcjonowanie fizyczne i psychiczne chorych po operacji, co niewątpliwie
korzystnie wplynie na polepszenie ich jakości zycia.
On semantic reefs and efficient processing of correlation queries with aggregates (1985)

Recent transformation algorithms for speeding up pro- cessing of nested SQL-like queries with aggregates are reviewed with respect to the correctness of aggregates over empty sets. It turns out that for a particular subset of such queries these algorithms fail to compute consistent answers. Unfortunately there seems to be no uniform way to do these transformations efficiently and correctly under all cir- cumstances. Also the algorithms for QUEL are reexamined regarding their correctness. It is shown that for a specific subset of QUEL-queries with aggregates a clearer semantics can be associated. Finally, benchmark results for lngres show that considerable performance advantages may be gained for such query types by using dynamic filters. The consequence of all these observations is that more research is required to integrate correlation queries with aggregates into a unified operator tree model.
Systematic analysis of genetic alterations in tumors using Cancer Genome WorkBench (CGWB) (2007)

Systematic investigations of genetic changes in tumors are expected to lead to greatly improved understanding of cancer etiology. To meet the analytical challenges presented by such studies, we developed the Cancer Genome WorkBench ( http://cgwb.nci.nih.gov ), the first computational platform to integrate clinical tumor mutation profiles with the reference human genome. A novel heuristic algorithm, IndelDetector, was developed to automatically identify insertion/deletion (indel) polymorphisms as well as indel somatic mutations with high sensitivity and accuracy. It was incorporated into an automated pipeline that detects genetic alterations and annotates their effects on protein coding and 3D structure. The ability of the system to facilitate identifying genetic alterations is illustrated in three projects with publicly accessible data. Mutagenesis in tumor DNA replication leading to complex genetic changes in the EGFR kinase domain is suggested by a novel deletion–insertion combination observed in paired tumor–normal lung cancer resequencing data. Automated analysis of 152 genes resequenced by the SeattleSNPs group was able to identify 91% of the 1251 indel polymorphisms discovered by SeattleSNPs. In addition, our system discovered 518 novel indels in this data set, 451 of which were found to be valid by manual inspection of sequence traces. Our experience demonstrates that CGWB not only greatly improves the productivity and the accuracy of mutation identification, but also, through its data integration and visualization capabilities, facilitates identification of underlying genetic etiology.
Frequency domain blind MIMO system identification based on second- and higher order statistics (2001)

We present a novel frequency-domain framework for the identification of a multiple-input multiple-output (MIMO) system driven by white, mutually independent, unobservable inputs. The system frequency response is obtained based on singular value decomposition (SVD) of a matrix constructed based on the power-spectrum and slices of polyspectra of the system output. By appropriately selecting the polyspectra slices, we can create a set of such matrices, each of which could independently yield the solution, of they could all be combined in a joint diagonalization scheme to yield a solution with improved statistical performance. The freedom to select the polyspectra slices allows us to bypass the frequency-dependent permutation ambiguity that is usually associated with frequency domain SVD, while at the same time allows us compute and cancel the phase ambiguity. An asymptotic consistency analysis of the system magnitude response estimate is performed.
A Compact EBG for High Isolation Between Two Very Closeby Wire-Antennas for RFID Tags (2019)

In this paper, we show a new scheme to tackle the problems of high electromagnetic-coupling, poor impedance-matching and degraded radiation-characteristics of two UHF-band RFID tag antennas, when they are very close. Using an inverted H-shaped EBG as a novel and compact structure, we insert it between the two antennas and prevent the unwanted interference and match the input impedance of both of the tag antennas. Also, the antenna gain of the two tags is -1.23 dBi which is larger than that of ordinary UHF-band tag antennas.
Optimization Scheduling for Flexible Manufacturing System using Petri net (2018)

This paper presents a new optimization scheduling method for manufacturing system based on the Timed Petri Net model and combined a heuristic search method. A Petri net model for flexible manufacturing system is proposed. FMS Optimization scheduling is determined by searching on Petri net`s reachability graph. A heuristic search algorithm is proposed to reach fast optimization results. Some experiments are carried out to demonstrate usefulness of our algorithm.
Optimized solar cells based on changes in resonance structure as a function of the refractive index and the thickness (2019)

In order to reduce costs, the solar cell industry is aiming at producing ever thinner solar cells. Structuring the surfaces of optically thin solar cells is important for avoiding excessive transmission-related losses and, hence, to maintain or increase their efficiency. Light trapping leading to longer optical path lengths within the solar cells is a well established field of research. In addition to this, other possible benefits of structured surfaces have been proposed. It has been suggested that nanostructures on the surface of thin solar cells function as resonators, inducing electric-field resonances that enhance absorption in the the energy-converting material. Further, coupling of electric field resonances in periodically structured solar cells may couple with each other thereby increasing the absorption of energy. A deeper understanding of the nature of the energy-conversion enhancement in surface-structured and thin solar cells would allow to design more targeted structures. Generally, efficiency enhancement may be evaluated by investigating the electric field and optimizing the optical generation rate. Here, we establish a model system consisting of multilayered solar cells in order to study resonances and coupling of resonances in a one-dimensional system. We show that resonances in energyconverting and non-energy converting layers exist. The coupling of resonances in the non-energy converting material and the energy-converting material is only possible for certain parameter ranges of thickness of the energy converting material and the imaginary part of the refractive index. We evaluate the resonances and the coupling of resonances in different thin-film systems and show how they affect the total absorption of energy in the energy converting layer. We show how resonances in non-absorbing layers can contribute to increasing the resonances in the absorbing layers. We optimize the parameters of the multilayered thin-film systems to achieve an increase in the amount of the absorbed energy. The optimization is also evaluated for an experimentally realizable thin-film solar cell.
Altering spinal cord excitability enables voluntary movements after chronic complete paralysis in humans (2014)

Previously, we reported that one individual who had a motor complete, but sensory incomplete spinal cord injury regained voluntary movement after 7 months of epidural stimulation and stand training. We presumed that the residual sensory pathways were critical in this recovery. However, we now report in three more individuals voluntary movement occurred with epidural stimulation immediately after implant even in two who were diagnosed with a motor and sensory complete lesion. We demonstrate that neuromodulating the spinal circuitry with epidural stimulation, enables completely paralysed individuals to process conceptual, auditory and visual input to regain relatively fine voluntary control of paralysed muscles. We show that neuromodulation of the sub-threshold motor state of excitability of the lumbosacral spinal networks was the key to recovery of intentional movement in four of four individuals diagnosed as having complete paralysis of the legs. We have uncovered a fundamentally new intervention strategy that can dramatically affect recovery of voluntary movement in individuals with complete paralysis even years after injury.