gebhart/patrepeval huggingface dataset:
The Teaching of Mass Communication Through the use of Computer- Assisted Picture Presentations in Cross River University of Technology, Calabar - Nigeria (2011)

Mass communication as a programme in education is an important subject in the training of students. Here, we determined the effects of improving the teaching of the subject in a tertiary institution like Cross River University of Technology through the use of computer assisted picture presentation. The study was quasi-experimental with all the year three and final year Mass Communication students as the study population. Data were generated through a 10 item multiple choice question for the pre-test and rearranged for the post-hoc test. Computer-Assisted teaching of mass communication had an overall, more positive impact on achievement and performance of the students than the conventional chalk-board and text books (CCT). Provision of enough computers would enhance teaching and learning at the tertiary level of education.
Effect of taurine administration on serum lipid and biliary lipid composition in man. (1989)

The effect of oral administration of taurine (3.2 g/day, 2 weeks) on the metabolism of lipids and bile acids was studied with healthy humans. Four male subjects were fed taurine. Another five male subjects were administered 1 g of cholesterol daily for two weeks and, at intervals of two weeks, cholesterol and taurine simultaneously. Serum lipoprotein and duodenal bile were analyzed. Oral administration of taurine resulted in the increase of taurine-conjugated bile acids. However, neither serum lipid nor biliary lipid composition was altered. Addition of taurine with cholesterol administration showed elevation of both the serum low density lipoprotein cholesterol level and the lithogenic index in bile. The ratio of glycine-to taurine-conjugated bile acids was changed from 4.1 to 0.63. The ratio of cholic acid/chenodeoxycholic acid was augmented from 0.57 to 0.81. The percentage of taurocholic acid, taurochenodexycholic acid and taurodeoxycholic acid were increased about 4-fold, 2.5-fold and 3-fold, respectively. Our results suggested that taurine administration alone did not influence the serum lipid level although taurine-conjugated bile acids were increased. The taurine intake would increase serum low density lipoprotein cholesterol and biliary cholesterol levels when excessive cholesterol is administered simultaneously.
TIMP2 promotes intramuscular fat deposition by regulating the extracellular matrix in chicken (2022)

The interaction between myocytes and intramuscular adipocytes is a hot scientific topic. Using a co-culture system, this study aims to investigate the regulation of intramuscular fat deposition in chicken muscle tissue through the interaction between myocyte and adipocyte and identify important intermediary regulatory factors. Our proteomics data showed that the protein expression of tissue inhibitor of metalloproteinases 2 (TIMP2) increased significantly in the culture medium of the co-culture system, and the content of lipid droplets was more in the co-culture intramuscular adipocytes. In addition, TIMP2 was significantly upregulated (P<0.01) in muscle tissue of individuals with high intramuscular fat content. Weighted gene co-expression network analysis revealed that TIMP2 was mainly involved in the extracellular matrix receptor interaction signaling pathway and its expression was significantly correlated with triglyceride, intramuscular fat, C14:0, C14:1, C16:0, C16:1, and C18:1n9C levels. Additionally, TIMP2 was co-expressed with various representative genes related to lipid metabolism (such as ADIPOQ, SCD, ELOVL5, ELOVL7, and LPL), as well as certain genes involved in extracellular matrix receptor interaction (such as COL1A2, COL4A2, COL5A1, COL6A1, and COL6A3), which are also significantly upregulated (P<0.05 or P<0.01) in muscle tissue of individuals with high intramuscular fat content. Our findings reveal that TIMP2 promotes intramuscular fat deposition in muscle tissue through the extracellular matrix receptor interaction signaling pathway.
Cell Cycle-dependent Regulation of a Human DNA Helicase That Localizes in DNA Damage Foci (2004)

Mutational studies of human DNA helicase B (HDHB) have suggested that its activity is critical for the G1/S transition of the cell cycle, but the nature of its role remains unknown. In this study, we show that during G1, ectopically expressed HDHB localizes in nuclear foci induced by DNA damaging agents and that this focal pattern requires active HDHB. During S and G2/M, HDHB localizes primarily in the cytoplasm. A carboxy-terminal domain from HDHB confers cell cycle-dependent localization, but not the focal pattern, to a reporter protein. A cluster of potential cyclin-dependent kinase phosphorylation sites in this domain was modified at the G1/S transition and maintained through G2/M of the cell cycle in vivo, coincident with nuclear export of HDHB. Serine 967 of HDHB was the major site phosphorylated in vivo and in vitro by cyclin-dependent kinases. Mutational analysis demonstrated that phosphorylation of serine 967 is crucial in regulating the subcellular localization of ectopically expressed HDHB. We propose that the helicase of HDHB operates primarily during G1 to process endogenous DNA damage before the G1/S transition, and it is largely sequestered in the cytoplasm during S/G2.
Catalytic Asymmetric Synthesis of .alpha.-Amino Phosphonates Using Lanthanoid-Potassium-BINOL Complexes (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCatalytic Asymmetric Synthesis of .alpha.-Amino Phosphonates Using Lanthanoid-Potassium-BINOL ComplexesHiroaki Sasai, Shigeru Arai, Yoshihiro Tahara, and Masakatsu ShibasakiCite this: J. Org. Chem. 1995, 60, 21, 6656–6657Publication Date (Print):October 1, 1995Publication History Published online1 May 2002Published inissue 1 October 1995https://pubs.acs.org/doi/10.1021/jo00126a003https://doi.org/10.1021/jo00126a003research-articleACS PublicationsRequest reuse permissionsArticle Views1294Altmetric-Citations209LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Identification of circulating myeloid cells as a potential diagnosis and recurrence marker of pancreatic ductal adenocarcinoma through the single-cell analysis (2022)

Abstract Background: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a poor survival rate, largely due to the lack of biomarker for early detection. Given the crucial roles of circulating and tumor-infiltrating myeloid cells in PDAC progression, the identification of specific subsets of them can be a biomarker in liquid biopsies for diagnosis and prediction of recurrence risk of PDAC. Methods: We analyzed PDAC tissue microarray by immunohistochemistry to measure cytokine expressions. Peripheral blood cells of PDAC patients were subjected to define distinct cell population of PDAC patients by single-cell RNA sequencing and flow cytometry. In addition, the presence of myeloid cells was analyzed by murine xenograft/orthotropic models of PDAC cell lines. Finally, we performed a clinical study to evaluate the correlation of IL-10R2 expression and PDAC diagnosis or recurrence. Results: We found enriched IL-10R2+/IL-22R1 + myeloid cells in peripheral blood from PDAC patients, and that they display a signature association with tumor-educated monocytes. In addition, we verified the positive correlation of pancreatic tumor growth with increased IL-10R2+/IL-22R1 + myeloid cells through the murine xenograft/orthotropic models. Most importantly, the IL-10R2 + myeloid cells signaled tumor recurrence 130 days faster than CA19-9 in post-pancreatectomy patients. Conclusions: Enriched IL-10R2 + myeloid cells in PDAC patient’s blood may benefit uncomplicated and effective diagnostic marker and indicator of recurrence.
Analysis of the line driver stage for transistorized T.V. receiver † (1972)

Abstract Complete analysis of a transistorized line-driver stage suitable for driving a transistorized line-output stage of a television receiver is described. All the parameters essential for the optimal design are brought out in the design equations and at the end the design summary describes the approach to the design.
Metabolism of Propionate, Glucose, and Carbon Dioxide as Affected by Exogenous Glucose in Dairy Cows at Energy Equilibrium (1990)

In vivo kinetic techniques were used to quantify changes in metabolism of propionate, glucose, and blood CO2 when glucose was infused intravenously at 0, 342, or 737 g/d into four lactating cows. Neither production of milk or milk fat nor composition of milk was changed. Production of milk protein increased for the high glucose treatment. Isotope dilution data were used to calculate irreversible losses of rumen propionate, plasma glucose, and blood CO2 and to determine a unique solution for flux of C in this three-pool system. Irreversible losses of propionate and CO2 were not changed. Infusions of glucose increased irreversible loss of glucose in proportion to amounts infused, thus indicating there was no change in endogenous production of glucose. For the control, 52% of the C flux of blood glucose was derived directly from rumen propionate and another 26% came from other gluconeogenic substrates. Flux of C into glucose from exogenous sources increased in proportion to amounts of glucose infused. Flux of C from rumen propionate remained constant. The rate of C leaving the glucose pool, other than as CO2, tended to increase with infusion of glucose, and oxidation of glucose tended to increase for the high glucose treatment. High producing cows adjusted to increased exogenous glucose by increasing glucose utilization and without decreasing endogenous glucose production.
Inhibition of melanogenesis as a radiation sensitizer for melanoma therapy (2008)

Melanin pigment displays strong photo- and radioprotective properties, suggesting that inhibition melanogenesis could increase sensitivity of melanoma to ionizing radiation. We tested this concept in human melanoma cells cultured in either Ham's F10 medium to maintain amelanotic phenotype or DMEM to induce/stimulate melanin production, respectively; N-phenylthiourea (PTU) and D-penicillamine were used as an inhibitor of melanogenesis. Melanogenic activity was evaluated by visual inspection (color of cell pellets) or by measurement of tyrosinase (dopa oxidase) activity assay. Amelanotic cells or cells with various melanin content were exposed to gamma radiation and tested for viability and colony forming capability. Gamma radiation at doses of 2-15 Gy inhibited cell viability and colony forming efficiency in dose- and time-dependent manner, but pigmented melanoma cells were significantly more resistant to gamma radiation than nonpigmented cells (p < 0.05-0.001). Both PTU and D-penicillamine inhibited strongly tyrosinase activity and melanin production in melanoma cells (p < 0.05-0.001). Furthermore, inhibition of melanogenesis by PTU or D-penicillamine resulted in enhancement of melanoma cells sensitivity to killing by gamma rays. In conclusion, the results of these cell culture experiments give support to a clinical trial of pharmacologically induced decrease in melanin synthesis to enhance the efficacy of radiotherapy in advanced melanomas.
Speech Intelligibility During Respirator Wear: Influences of Respirator Speech Diaphragm Size and Background Noise (2003)

Abstract This study assessed the effect of respirator speech device size on speech intelligibility and the impact of background noise on respirator communications effectiveness. Thirty-five subjects completed modified rhyme test (MRT) speech intelligibility testing procedures with and without a respirator under background noises of 40, 60, and 80 dBA. Respirator wear conditions included the use of one unmodified and three mechanical speech diaphragms modified to reduce the surface area of the vibrating inner membrane available for sound transmission. Average MRT scores decreased linearly as background noise levels increased for all conditions. Lower MRT scores were observed for all respirator speech diaphragm conditions compared to the nonrespirator condition within each noise category. Average MRT scores differed significantly between the unmodified speech diaphragm and one with a 70% reduced surface area with a 40-dBA background noise. However, MRT scores were similar between the modified and unmodified diaphragms at both the 60- and 80-dBA noise levels. These findings provide evidence that alternate designs of mechanical-type respirator speech devices can be achieved without further degradation of speech sound transmission. Keywords: respiratorsspeech diaphragmspeech intelligibility
Basics of SQL for Audit Data Retrieval and Analysis (2021)

ABSTRACT The purpose of this instructional resource is to explain how Structured Query Language (SQL) queries can help auditors to independently retrieve properly formatted data as audit evidence or for further analyses. It demonstrates data extraction using Microsoft (MS) Access, one of the simplest SQL-compliant database software applications. We use a dataset fragment that is extracted from the publicly available enterprise datasets provided by Walton College (University of Arkansas) to run SQL queries as a part of audit investigations. Data extraction is the first step of Extract, Transform, and Load (ETL) and may be time-consuming. We demonstrate how SQL queries can assist with this task, thereby allowing the auditor to begin analysis sooner. This instructional resource can be used to prepare future auditors for the emerging data-rich and technology-driven business environment.
Destabilizing Attack and Robust Defense for Inverter-Based Microgrids by Adversarial Deep Reinforcement Learning (2023)

&lt;p&gt;The droop controllers of inverter-based resources (IBRs) can be adjustable by grid operators to facilitate regulation services. Considering the increasing integration of IBRs at power distribution level systems like microgrids, cyber security is becoming a major concern. This paper investigates the data-driven destabilizing attack and robust defense strategy based on adversarial deep reinforcement learning for inverter-based microgrids. Firstly, the full-order high-fidelity model and reduced-order small-signal model of typical inverter-based microgrids are recapitulated. Then the destabilizing attack on the droop control gains is analyzed, which reveals its impact on system small-signal stability. Finally, the attack and defense problems are formulated as Markov decision process (MDP) and adversarial MDP (AMDP). The problems are solved by twin delayed deep deterministic policy gradient (TD3) algorithm to find the least effort attack path of the system and obtain the corresponding robust defense strategy. The simulation studies are conducted in an inverter-based microgrid system with 4 IBRs and IEEE 123-bus system with 10 IBRs to evaluate the proposed method. &lt;br&gt; &lt;/p&gt;
Surface Display of Foreign Epitopes on the Lactobacillus brevis S-Layer (2002)

So far, the inability to establish viable Lactobacillus surface layer (S-layer) null mutants has hampered the biotechnological applications of Lactobacillus S-layers. In this study, we demonstrate the utilization of Lactobacillus brevis S-layer subunits (SlpA) for the surface display of foreign antigenic epitopes. With an inducible expression system, L. brevis strains producing chimeric S-layers were obtained after testing of four insertion sites in the slpA gene for poliovirus epitope VP1, that comprises 10 amino acids. The epitope insertion site allowing the best surface expression was used for the construction of an integration vector carrying the gene region encoding the c-Myc epitopes from the human c-myc proto-oncogene, which is composed of 11 amino acids. A gene replacement system was optimized for L. brevis and used for the replacement of the wild-type slpA gene with the slpA-c-myc construct. A uniform S-layer, displaying on its surface the desired antigen in all of the S-layer protein subunits, was obtained. The success of the gene replacement and expression of the uniform SlpA-c-Myc recombinant S-layer was confirmed by PCR, Southern blotting MALDI-TOF mass spectrometry, whole-cell enzyme-linked immunosorbent assay, and immunofluorescence microscopy. Furthermore, the integrity of the recombinant S-layer was studied by electron microscopy, which indicated that the S-layer lattice structure was not affected by the presence of c-Myc epitopes. To our knowledge, this is the first successful expression of foreign epitopes in every S-layer subunit of a Lactobacillus S-layer while still maintaining the S-layer lattice structure.
Synthesis and Photochemical Properties of White Calcia-Doped Ceria Nanoparticles via Soft Solution Processes (2006)

White nanoparticles of calcia-doped ceria were prepared from the precipitate by reacting CeCl3-CaCl2 mixed solution with NaOH solution at pH 12 and the oxidation with hydrogen peroxide solution at 40oC, followed by the calcination at 700oC for 1 h. The sample before calcination contained significant amount of OH- in the lattice and was yellow, but the powders calcined above 700oC were white, indicating that cationic defect formed by replacing O2- with OH- played as the color center. Calcia-doped ceria particles were coated with amorphous silica by means of seeded polymerization technique using hydrolysis of tetraethylorthosilicate (TEOS) or acid hydrolysis of sodium silicate. The silica coating by seeded polymerization with TEOS was much more efficient for the reduction of catalytic activity of ceria for the oxidation of organic materials than that by acid hydrolysis of sodium silicate. It is confirmed that ceria particles caused far less damage to the DNA plasmids upon UV illumination than either the titania or the zinc oxide reference pigments.
Conventional PD measurement techniques used for complex HV apparatus (1992)

The aim of conventional potential discharge (PD) measuring techniques is the quantification of an apparent charge q, which is, in general, provided by band-pass filter techniques. However, as the capability of a filter to integrate signals and its 'pulse resolution time' are strongly interlinked with the band-pass characteristics of the filters, the design of conventional PD measuring circuits appears quite arbitrary. The authors discuss, therefore, some deficiencies of the Standards, which are inadequate for designing standardized PD instruments. The interaction between band-pass filter parameters and pulse resolution as defined in IEC Standard 270 is investigated. A complete PD testing and measuring circuit for GIS components is simulated and shows the difficulties in applying conventional PD measuring circuits to such complex systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Regulation of epithelial sodium channels in urokinase plasminogen activator deficiency (2014)

Epithelial sodium channels (ENaC) govern transepithelial salt and fluid homeostasis. ENaC contributes to polarization, apoptosis, epithelial-mesenchymal transformation, etc. Fibrinolytic proteases play a crucial role in virtually all of these processes and are elaborated by the airway epithelium. We hypothesized that urokinase-like plasminogen activator (uPA) regulates ENaC function in airway epithelial cells and tested that possibility in primary murine tracheal epithelial cells (MTE). Both basal and cAMP-activated Na + flow through ENaC were significantly reduced in monolayers of uPA-deficient cells. The reduction in ENaC activity was further confirmed in basolateral membrane-permeabilized cells. A decrease in the Na + -K + -ATPase activity in the basolateral membrane could contribute to the attenuation of ENaC function in intact monolayer cells. Dysfunctional fluid resolution was seen in uPA-disrupted cells. Administration of uPA and plasmin partially restores ENaC activity and fluid reabsorption by MTEs. ERK1/2, but not Akt, phosphorylation was observed in the cells and lungs of uPA-deficient mice. On the other hand, cleavage of γ ENaC is significantly depressed in the lungs of uPA knockout mice vs. those of wild-type controls. Expression of caspase 8, however, did not differ between wild-type and uPA −/− mice. In addition, uPA deficiency did not alter transepithelial resistance. Taken together, the mechanisms for the regulation of ENaC by uPA in MTEs include augmentation of Na + -K + -ATPase, proteolysis, and restriction of ERK1/2 phosphorylation. We demonstrate for the first time that ENaC may serve as a downstream signaling target by which uPA controls the biophysical profiles of airway fluid and epithelial function.
Nitrogen Removal of Municipal Wastewaters Using a Floodplain Filtration Technique (2003)

The wide natural flood plains of many rivers and streams can be used for filtration toremove contaminants from secondary treated wastewaters. If contaminated river water is sprayedover the floodplain, the water-borne organic matter can be expected to decompose under the actionof soil microbes and in this process NO3-, an electron acceptor, can be simultaneously removed bydenitrification. A lysimeter study was undertaken to study three different wastewater application ratesand a comparison of two topsoil conditions, i.e. bare soil vs sod. It was found that 30 l/d flow rate wasmore efficient in removing nitrate and ammonium from wastewater than both 50 l/d and 10 l/d. Therewas no significant difference between the two top conditions. The floodplain filtration techniquerequires no chemicals additives and produces no sludge, making it an environmentally friendlyprocess. For relatively low contaminant concentrations, its construction and operation costs wouldalso be lower than those of conventional techniques.
The influence of a biofilm‐dispersing wound gel on the wound healing process (2021)

Topical antimicrobials that reduce the bacterial bioburden within a chronically-infected wound may have helpful or harmful effects on the healing process. We used murine models of full-thickness skin wounds to determine the effects of the novel biofilm-dispersing wound gel (BDWG) and its gel base on the healing of uninfected wounds. The rate of wound closure over 19 days was comparable among the BDWG-treated (BT) wounds and the controls. Compared with the controls, histology of the BT wounds showed formation of a stable blood clot at day 1, more neovascularisation and reepithelialisation at day 3, and more organised healing at day 7. Fluorescence-activated cell sorting analysis showed a lower percentage of neutrophils in wounded tissues of the BT group at days 1 and 3, and significantly more M2 macrophages at day 3. Levels of proinflammatory cytokines and chemokines were increased over the uninjured baseline within the wounds of all treatment groups but the levels were significantly lower in the BT group at day 1, modulating the inflammatory response. Our results suggest that BDWG does not interfere with the wound healing process and may enhance it by lowering inflammation and allowing transition to the proliferative stage of wound healing by day 3.