gebhart/patrepeval huggingface dataset:
Tumor-Penetrating Peptide-Modified DNA Tetrahedron for Targeting Drug Delivery (2016)

DNA self-assembling nanostructure has been considered as a promising candidate as a drug delivery vehicle because of its compactness, mechanical stability, and noncytotoxicity. In this work, we developed functional, multiform DNA nanostructures by appending a tumor-penetrating peptide to tetrahedral DNA nanostructure (p-TDN). This functional structure is able to efficiently increase the rate of uptake of glioblastoma cell U87MG compared with the DNA tetrahedron and the double-stranded DNA structures. We found that the DNA tetrahedron plays the main role in the endocytosis of U87MG cells, whereas the tumor-penetrating peptide could also bind to transmembrane glycoprotein neuropilin-1 and mediate the endocytosis of the p-TDN nanostructure. Moreover, given the high efficiency of the growth inhibitory effect of the p-TDN loading doxorubicin hydrochloride, the p-TDN distinguishes itself as a promising candidate as an effective delivery carrier.
Current treatments for patients with Alzheimer disease. (2010)

There is neither proven effective prevention for Alzheimer disease nor a cure for patients with this disorder. Nevertheless, a spectrum of biopsychosocial therapeutic measures is available for slowing progression of the illness and enhancing quality of life for patients. These measures include a range of educational, psychological, social, and behavioral interventions that remain fundamental to effective care. Also available are a number of pharmacologic treatments, including prescription medications approved by the US Food and Drug Administration for Alzheimer disease, "off-label" uses of medications to manage target symptoms, and controversial complementary therapies. Physicians must make the earliest possible diagnosis to use these treatments most effectively. Physicians' goals should be to educate patients and their caregivers, to plan long-term care options, to maximally manage concurrent illnesses, to slow and ameliorate the most disabling symptoms, and to preserve effective functioning for as long as possible. The authors review the various current treatments for patients with Alzheimer disease.
Skeletal Structure of the Chromophore of Photoactive Yellow Protein in the Excited State Investigated by Ultraviolet Femtosecond Stimulated Raman Spectroscopy (2021)

We studied ultrafast structural dynamics of photoactive yellow protein (PYP) using ultraviolet femtosecond stimulated Raman spectroscopy. By employing the Raman pump and probe pulses in the ultraviolet region, resonantly enhanced, rich vibrational features of the excited-state chromophore were observed in the fingerprint region. In contrast to the marked spectral change reported for the excited-state chromophore in solution, in the protein, all of the observed Raman bands in the fingerprint region did not show any noticeable spectral shifts nor band shape changes during the excited-state lifetime of PYP. This indicates that the significant skeletal change does not occur on the chromophore in the excited state of PYP and that the <i>trans</i> conformation is retained in its lifetime. Based on the femtosecond Raman data of PYP obtained so far, we discuss a comprehensive picture of the excited-state structural dynamics of PYP.
SOURCES WANTED (1975)

Journal Article SOURCES WANTED Get access A. D. BURNETT A. D. BURNETT University of DurhamDurham Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume 22, Issue 2, February 1975, Pages 76-a–76, https://doi.org/10.1093/nq/22-2-76a Published: 01 February 1975
Control of burn wound sepsis in rats by methylene blue-mediated photodynamic treatment (2012)

Control of wound sepsis is an important challenge in traumatology. However, increase in the drug-resistant bacteria makes this challenge considerably difficult in recent years. In this study, we attempted to control burn wound sepsis in rats by photodynamic treatment, which has been reported to be effective against some drug-resistant bacteria. A 20% TBSA (total body surface area) full-thickness burn was made in rat dorsal skin, and five days after injury, a suspension of P. aeruginosa was applied to the wound surface. At 30 min after infection, a methylene blue (MB) solution was applied to the wound surface; 5 min afterwards, the wound was illuminated with a 665-nm light emitting diode (LED) array for 10 min. This treatment (application of MB and illumination) was repeated 3 times successively. The averaged light intensity on the wound surface was 3.3 mW/cm<sup>2</sup>, the corresponding total light dose being 5.9 J/cm<sup>2</sup>. One week after injury, the numbers of bacteria in the blood and liver were counted by colony forming assay. In the liver, the number of bacteria of the treated group was significantly lower than that of the sham control group without photodynamic treatment. In the blood, no bacteria were detected in the treated group, while a certain amount of bacteria was detected in the control group. These results demonstrate the efficacy of MB-mediated PDT with a red LED array to control burn wound sepsis.
Identification of Anti-Persister Activity against Uropathogenic Escherichia coli from a Clinical Drug Library (2015)

Uropathogenic E. coli is a major cause of urinary tract infections (UTIs), but current antibiotics do not always effectively clear the persistent infection. To identify drugs that eliminate uropathogenic E. coli persisters, we screened a clinical drug library consisting of 1524 compounds using high throughput drug exposure assay in 96-well plates. Bacterial survival was assessed by growth on LB plates. We identified 14 drug candidates (tosufloxacin, colistin, sparfloxacin, moxifloxacin and gatifloxacin, enrofloxacin and sarafloxacin, octodrine, clofoctol, dibekacin, cephalosporin C, pazufloxacin, streptomycin and neomycin), which had high anti-persister activity. Among them, tosufloxacin and colistin had the highest anti-persister activity and could completely eradicate E. coli persisters in 3 days in vitro while the current UTI antibiotics failed to do so. Our findings may have implications for the development of a more effective treatment for UTIs.
Unorthodox C,O Binding Mode of Me2BINOL in Pt(II) Complexes (1998)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTADDITION / CORRECTIONThis article has been corrected. View the notice.Unorthodox C,O Binding Mode of Me2BINOL in Pt(II) ComplexesNicole M. Brunkan, Peter S. White, and Michel R. GagnéView Author Information Department of Chemistry, CB#3290 University of North Carolina Chapel Hill, North Carolina 27599-3290 Cite this: J. Am. Chem. Soc. 1998, 120, 42, 11002–11003Publication Date (Web):October 10, 1998Publication History Received22 June 1998Published online10 October 1998Published inissue 1 October 1998https://pubs.acs.org/doi/10.1021/ja982143fhttps://doi.org/10.1021/ja982143frapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views242Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information SUBJECTS:Binding modes,Conformation,Ligands,Organophosphorus compounds,Platinum Get e-Alerts
DNMT1 and DNMT3b silencing sensitizes human hepatoma cells to TRAIL‐mediated apoptosis via up‐regulation of TRAIL‐R2/DR5 and caspase‐8 (2010)

DNA methylation plays a critical role in chromatin remodeling and gene expression. DNA methyltransferases (DNMTs) are hypothesized to mediate cellular DNA methylation status and gene expression during mammalian development and in malignant diseases. In this study, we examined the role of DNA methyltransferase 1 (DNMT1) and DNMT3b in cell proliferation and survival of hepatocellular carcinoma (HCC) cells. Gene silencing of both DNMT1 and DNMT3b by targeted siRNA knockdown reduces cell proliferation and sensitizes the cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated cell death. The proapoptotic protein caspase-8 demonstrated promoter hypermethylation in HCC cells and was up-regulated by knockdown of DNMT1 and DNMT3b both at mRNA and protein levels. In addition, death receptor TRAIL-R2/DR5 (TRAIL receptor 2/death receptor 5) did not exhibit promoter hypermethylation in HCC cells but was also up-regulated by knockdown of DNMT1 and DNMT3b both at mRNA and protein levels. Consistent with this observation, the combined transfection of DNMT1-siRNA plus DNMT3b-siRNA enhanced formation of the TRAIL-death-inducing signaling complex formation in HCC cells. In conclusion, our data suggest that DNA methylation of specific genomic regions maintained by DNMT1 and DNMT3b plays a critical role in survival of HCC cells, and a simultaneous knockdown of both DNMT1 and DNMT3b may be a novel anticancer strategy for the treatment of HCC.
σ-COORDINATE MODEL OF THE BLACK SEA BY THE ALGORITHM OF ADAPTIVE STATISTICS (2009)

We realize the algorithm of adaptive statistics of forecasting errors for the assimilation of the climatic fields of temperature and salinity in the σ-coordinate model of the dynamics of the Black Sea. The principal relations of this algorithm and its simplified version based on the Kalman filter are presented. The distinctive features of realization of the algorithm specified by the model are discussed. We also present the results of comparison of the hydrophysical fields of the Black Sea reconstructed according to the algorithm of adaptive statistics and a simplified scheme of assimilation of the climatic data. It is shown that the dependence of sources in the transport equations (heat and salt diffusion) on the four-dimensional variances of forecasting errors and threedimensional measurement errors enables one to reconstruct the mutually adapted climatic parameters of the sea more exactly.
The superconducting state of YBa[sub 2]Cu[sub 3]O[sub 7[minus][delta]]. [Deviations from detailed predictions of BCS theory] (1992)

Many low temperature properties of high [Tc] superconductors deviate significantly from the detailed predictions of BCS theory. Here the authors discuss whether these effects could be caused by either: (a) an unconventional pairing state, or (b) local randomness in the gap function due to the intrinsic disorder. They review recent experiments pertinent to these questions: Josephson effects in (001) oriented planar junctions between YBa[sub 2]Cu[sub 3]O[sub 7[minus][delta]] and classic superconductors and the temperature dependence of the a-b plane electromagnetic penetration depth at low temperatures. They also calculate the density of states of s-wave superconductors with local quenched disorder in the gap function so as to determine whether s-wave pairing could be consistent with the low energy quasi-particle excitations seen in many experiments.
Supramolecular inorganic frameworks: “dynamic” challenges for structural chemistry (2005)

Abstract The supramolecular chemistry of discrete assemblies of various topologies (cages, grids, helices, etc.) has been extensively studied. With regards to the supramolecular chemistry of infinite solids, attention is usually focussed on the design of an efficient, programmed assembly motif through the choice of suitable building blocks. However, as well illustrated by the discrete structures, a hallmark property of a supramolecular system is its ability to reversibly assemble to optimize its structure, effectively error checking. For a rigid infinite framework, this feature is less obvious. Error checking is manifested in an extended framework through structural rearrangements in the solid state. Coordination frameworks, as they are often at least partially sustained by weaker interactions, can demonstrate such dynamic behavior in response to some external stimulus. Selected examples, chosen to illustrate a range of network types and rearrangements, will be discussed in this short review.
Exploring the locally low dimensional structure in solving random elliptic PDEs (2016)

We propose a stochastic multiscale finite element method (StoMsFEM) to solve random elliptic partial differential equations with a high stochastic dimension. The key idea is to simultaneously upscale the stochastic solutions in the physical space for all random samples and explore the low stochastic dimensions of the stochastic solution within each local patch. We propose two effective methods to achieve this simultaneous local upscaling. The first method is a high order interpolation method in the stochastic space that explores the high regularity of the local upscaled quantities with respect to the random variables. The second method is a reduced-order method that explores the low rank property of the multiscale basis functions within each coarse grid patch. Our complexity analysis shows that compared with the standard FEM on a fine grid, the StoMsFEM can achieve computational saving in the order of $(H/h)^{d}/(\log(H/h))^k$, where $H/h$ is the ratio between the coarse and the fine gird sizes, $d$ is the physical dimension and $k$ is the local stochastic dimension. Several numerical examples are presented to demonstrate the accuracy and effectiveness of the proposed methods. In the high contrast example, we observe a factor of 2000 speed-up.
Composition, Structure, and Integrity of Casein Micelles: A Review (1984)

This review is an attempt to bring what is known about casein micelles together into a coherent summary. Some of the earlier models and theories no longer appear workable, and much is left to be concluded on this subject. It is hoped with what we now know that those who already have contributed and others will continue to pursue the understanding of casein micelles.
Transmission Reinforcements in the Central American Power System Phase 2 - Final report (2015)

Page Not Found - If you're seeing this page, it's because the URL you requested cannot be located. It might not exist or maybe you mistyped it into your browser. But, if you think it's our mistake, please let us know. Otherwise, you have a few options: try using our navigation bar at the top of this page, visit our home page, or browse our products below. - Homepage Basic Content,
Locomotion Assistance for the Person with Mobility Impairment: Fuzzy Control of Cycling Movement by Means of Surface Electrical-Stimulation (2007)

Since a wheelchair was originally designed as a transportation vehicle for people who can not walk well due to the degenerative muscles of legs in the case elderly and disabled persons, it was not considered to use lower limbs to drive a wheelchair. Wheelchairs driven by arms cause a shoulder disorder, atrophy of leg muscles and a contracture of leg joints. On the other hand, while wheelchairs driven by legs can prevent or alleviate those symptoms in daily life, it is difficult to drive a wheelchair if the muscles are not strong enough. To solve this problem the functional electrical stimulation is carried out on leg muscles to pedal the wheelchair, and to stabilize the speed a motor is equipped. The leg cycling movement in this paper is controlled by fuzzy logic. Experiments of cycling using three healthy young men are performed on a level surface, and prove the effectiveness of smooth cycling movement. The electrical stimulation is also added to the external oblique of subjects sitting on a chair to examine the possibility to become effective exercise instead of treadmill training by keeping balance.
ChemInform Abstract: Catalytic Formation of an Amide Hydroperoxide and Hydrogen Peroxide Using Rhodium Complexes and Dioxygen/Dihydrogen Mixtures. (1990)

Abstract Treatment of N,N‐dimethylacetamide (I) with oxygen and hydrogen in the presence of a rhodium(III) catalyst results in the formation of the hydroperoxide (II), the formamide (III), and hydrogen peroxide (IV).
Mapping of the mouse atrial natriuretic factor gene. Evidence for tight linkage to the Fv-1 locus. (1987)

The importance of atrial natriuretic factor (ANF) in the regulation of salt balance and blood pressure is now widely recognized, and it would be extremely informative for both physiologists and molecular biologists to have mutants available that exhibit abnormal expression of this peptide hormone. The most direct mutation would affect the structural gene itself by altering either its coding potential or its regulation. With this aim in mind, it is of considerable interest to accurately determine the chromosomal position of the ANF gene (Anf) in the mouse. This information would permit a comparison with known mutations and provide a means of screening for mutations at this locus. Using recombinant inbred mouse strains, we undertook the mapping of the mouse Anf gene and demonstrated linkage of the gene to the Friend virus susceptibility-1 (Fv-1) locus on chromosome 4. The mapping was performed using a restriction fragment length polymorphism extant between the two parental strains. No recombination event between Anf and the Fv-1 locus was evident in any of the 34 strains tested. The assignment of Anf to this region of chromosome 4 coincides with the reported position of the cribriform degeneration mutation, which includes in its phenotype an abnormal electrolyte distribution. We have, therefore, begun studying this mutation to determine whether a defect in ANF expression is the underlying cause of the phenotype. Thus far, we have found no major DNA rearrangement close to the Anf gene.
Chromium Tolerant Microbial Communities from the Chesapeake Bay Watershed (2002)

Chromium tolerant bacteria were enumerated from portions of the Chesapeake Bay watershed and examined for their potential to reduce Cr(VI). Water and sediment samples were collected from various locations in Baltimore Harbor and Bear Creek, as well as Sandy Point State Park in Maryland and the Anacostia River in Washington, DC. Samples were spread onto agar plates with CrO42- (5 ppm) as the sole terminal electron acceptor. Plates were incubated anaerobically and colony forming units (CFU) enumerated. CFU arising on minimal-CrO42- medium ranged from 103-104 mL-1 or g-1 and community estimates from sites in proximity to Baltimore City were approximately 6-30X higher than distal sites. Bacterial identification by BIOLOG™ or 16S rRNA sequencing indicated the presence of bacteria of the genera Klebsiella, Pseudomonas, Burkholderia, Kluyvera and others. Typical Cr(VI) reduction rates by these isolates were significantly lower than Shewanella oneidensis, a known metal-reducing bacterium. Results suggested that microbial communities in the Chesapeake Bay watershed, particularly in Baltimore Harbor and Bear Creek, had a high tolerance for Cr(VI) and/or could grow slowly with Cr(VI) as a terminal electron acceptor. However, the isolates did not rapidly degrade Cr(VI) in the laboratory.
A 512Gb 3b/Cell 3D flash memory on a 96-word-line-layer technology (2018)

The first multi-layer stacked 3D Flash memory was proposed as BiCS FLASH in 2007 [1]. Since then, memory bit density has grown rapidly due to the increase in the number of stacked layers from continuous 3D technology innovations. On the other hand, the multi-level-cell technology, which was initially proposed for 2D Flash, has also been adopted to 3D Flash memories. The first 3b/cell 32-layer Flash was presented in 2015 [2], followed by a 48-layer one in 2016 [3], and a 64-layer one in 2017 [4,5]. This paper describes a 512Gb 3b/cell 3D Flash memory in a 96-word-line-layer BiCS FLASH technology. This work implements three key technologies to improve performance: (1) a string based start bias control scheme achieves a 7% shorter program time; (2) a smart V <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">t</inf> -tracking read improves read retry performance by minimizing the tracking time and supporting a program suspend read function, and; (3) a low-pre-charge sense-amplifier bus scheme reduces both the power consumption and the data-transfer time between the sense amplifier (SA) and the data cache by half. Figure 20.1.1 shows the die micrograph and the summary of the key features of the chip.
Generation of multiple VUV dispersive waves using a tapered gas-filled hollow-core anti-resonant fiber (2017)

An Ar-filled hollow-core anti-resonant (HC-AR) fiber with a taper profile in order to generate strong and blue-shifted multiple dispersive waves (DWs) down to the extreme VUV region is investigated. The proposed fiber structure provides additional degree of freedom in which tunable DWs emission towards more deep-UV is possible by simply changing the gas pressure, pulse energy, or by tapering the fiber.
Preliminary evaluation of AS-013 (prodrug of prostaglandin E1) administration for chronic peripheral arterial occlusive disease (1998)

Prostaglandin E1 (PGE1) and one of its prodrugs, AS-013, were formulated in lipid microspheres (lipo-PGE1 and lipo-AS, respectively), and their acute clinical efficacy and safety were compared in a randomized, placebo-controlled, single-blind test. Lipo-PGE1 (10 μg), lipo-AS (5 μg), or an inactive placebo was intravenously administered to human subjects once daily for 3 days. The acute efficacy of lipo-PGE1 and lipo-AS was each quantitatively assessed in male patients with chronic peripheral arterial occlusive diseases (PAOD) by measuring ankle brachial pressure, skin temperature, transcutaneous oxygen pressure (tcPO2), transcutaneous carbonic dioxide pressure, and cutaneous blood flow (BF) with a laser Doppler flowmeter during and after administration of each drug. Informed consent was obtained from all patients. Laboratory data did not suggest any adverse effect of lipo-AS administration, which significantly improved tcPO2 and BF, suggesting that the microhemorrheological effects of lipo-AS are of potential therapeutic value in the treatment of PAOD.