gebhart/patrepeval huggingface dataset:
Light Manipulation in Metallic Nanowire Networks with Functional Connectivity (2016)

Guided by ideas from complex systems, a new class of network metamaterials is introduced for light manipulation, which are based on the functional connectivity among heterogeneous subwavelength components arranged in complex networks. The model system is a nanonetwork formed by dealloying a metallic thin film. The connectivity of the network is deterministically controlled, enabling the formation of tunable absorbing states.
Scalable Functional Assays for the Interpretation of Human Genetic Variation (2022)

Scalable sequence-function studies have enabled the systematic analysis and cataloging of hundreds of thousands of coding and noncoding genetic variants in the human genome. This has improved clinical variant interpretation and provided insights into the molecular, biophysical, and cellular effects of genetic variants at an astonishing scale and resolution across the spectrum of allele frequencies. In this review, we explore current applications and prospects for the field and outline the principles underlying scalable functional assay design, with a focus on the study of single-nucleotide coding and noncoding variants.
Computational design of nanostructural color for additive manufacturing (2018)

Additive manufacturing has recently seen drastic improvements in resolution, making it now possible to fabricate features at scales of hundreds or even dozens of nanometers, which previously required very expensive lithographic methods. As a result, additive manufacturing now seems poised for optical applications, including those relevant to computer graphics, such as material design, as well as display and imaging applications. In this work, we explore the use of additive manufacturing for generating structural colors, where the structures are designed using a fabrication-aware optimization process. This requires a combination of full-wave simulation, a feasible parameterization of the design space, and a tailored optimization procedure. Many of these components should be re-usable for the design of other optical structures at this scale. We show initial results of material samples fabricated based on our designs. While these suffer from the prototype character of state-of-the-art fabrication hardware, we believe they clearly demonstrate the potential of additive nanofabrication for structural colors and other graphics applications.
Motion of a Compact Toroid inside a Cylindrical Flux Conserver (1980)

Compact toroids have been generated in a cylindrical resistive flux conserver. They are observed to rotate so that their major axis is perpendicular to the axis of the flux conserver. Subsequently they remain stationary and their magnetic fields decay with a time constant of about 100 \ensuremath{\mu}s. This is the first observation of the predicted tipping mode and its saturation when no external fields are present. The compact toroids contain toroidal fields and are initially prolate in shape.
Rural India Market-Creating Growth by Communication (2011)

IJAR - Indian Journal of Applied Research (IJAR) IJAR is a double reviewed monthly print journal that accepts research works from scholars, academicians, professors, doctorates, lecturers, and corporate in their respective expertise of studies.
In vitro anti‐myeloma activity of the Aurora kinase inhibitor VE‐465 (2009)

This study characterized the preclinical anti-myeloma activity of VE465, a low molecular weight pan-Aurora kinase inhibitor. After 96-h drug exposure, several multiple myeloma (MM) cell lines were more sensitive to VE465 compared to non-malignant cells. The anti-MM activity of VE465 was maintained in the presence of interleukin-6 and, interestingly, enhanced by co-culture with stromal cells. However, primary MM cells were less responsive than cell lines. Combinations with dexamethasone (Dex), doxorubicin (Doxo) and bortezomib showed no antagonism. Our study highlights the potential role of the tumour microenvironment in modulating the activity of this drug class.
Activation of Racemic Ethylene-Bridged Bis(indenyl)-Type Siloxy-Substituted Zirconocenes with Methylaluminoxane. A Combined UV/vis Spectroscopic and ab Initio Hartree−Fock Study (2002)

Lowest energy ligand-to-metal charge-transfer (LMCT) transitions of racemic siloxy-substituted ethylene-bridged bis(indenyl)-type zirconocenes reacted with methylaluminoxane (MAO) were studied using UV/vis spectroscopy in combination with the ab initio Hartree−Fock method. The LMCT absorptions were recorded at various [Al]/[Zr] ratios, representing dichloride, methylated, and cationic forms of the zirconocenes. The experimental LMCT absorption energies of each intermediate were compared to the calculated energies of the indenyl ligand-based HOMO and the zirconium-based LUMO. The lowest energy LMCT absorptions were directly proportional to the calculated LUMO−HOMO energy gaps. Furthermore, the LMCT absorption energies were demonstrated to correlate with ethylene polymerization activity of the siloxy-substituted complexes. This correlation was clarified by a frontier orbital analysis, suggesting that decreasing absorption energy is related to the feasibility of the activation of the catalyst.
All-fiber side pump combiner for high-power fiber lasers and amplifiers (2010)

We present an all-fiber side pump combiner for high power fiber lasers and amplifiers. It consists of a capillary with decreasing wall thickness fused around the active fiber in a way that it becomes an additional cladding layer of it. The pump fibers are spliced at the edge of the capillary with the thickest wall. This provides enough room to allocate around 12 pump fibers (100&mu;m diameter) in a standard 400&mu;m double-clad fiber. This side pump combiner offers several advantages such as the fact that it does not interrupt the active fiber core at any point, thus allowing for truly monolithic all fiber lasers and amplifiers. Additionally, the pump light is coupled into the active double-clad fiber all along the combiner's body (~ 1-2 cm long), which avoids the concentration of heat in a very small area, resulting in high pump power handling capabilities. If the taper angle of the capillary wall is low enough a high coupling efficiency (&lt; 95%) is possible. Using this structure we have achieved a maximum combined pump power of 86 Watt from 7 pump diodes. This, we believe, is the highest combined pump power reported so far from a single lumped side pump combiner.
Decreasing Racial Disparity with Interferon-Free Regimens in African American Patients with Chronic Hepatitis C (2016)

Introduction: Racial disparity in response to hepatitis C treatments when comparing African Americans (AA) to Caucasians (Cau) was a disconcerting finding in the Interferon-Ribavirin treatment era. The objective of this study was to compare combinations of direct acting anti-viral agents (DAAs) to single DAA administered with ribavirin and interferon (R+I+DAA) in AA patients. Methods: Data from the medical records of patients treated with a DAA from Aug 2011 to March 2016 were included in this IRB-approved study. Response rate to therapy with DAAs or R+I+DAA was calculated as intent to treat (ITT), and sustained viral response (SVR) was defined as a negative HCV PCR assay 12 weeks after completion of therapy. AST-Platelet Ratio Index (APRI) was used to assess improvement in fibrosis following treatment. Results: The majority of the 325 patients were African American (89%), Male (60%) and Genotype 1 (97%) with a median age of 61 years of age. Combination DAAs were used in 67% of the patients with the remaining receiving R+I+DAA. There were more naive patients in the combination DAAs group as compared to R+I+DAA group (47% vs 26% (AA); 54% vs 13% Cau). SVR for AA Genotype 1 patients receiving combination DAAs as compared to R+I+DAA was significantly better (96% vs 37%; Pearson p. Conclusion: The majority of the 325 patients were African American (89%), Male (60%) and Genotype 1 (97%) with a median age of 61 years of age. Combination DAAs were used in 67% of the patients with the remaining receiving R+I+DAA. There were more naive patients in the combination DAAs group as compared to R+I+DAA group (47% vs 26% (AA); 54% vs 13% Cau). SVR for AA Genotype 1 patients receiving combination DAAs as compared to R+I+DAA was significantly better (96% vs 37%; Pearson p.
Cross-linking of Orai1 channels by STIM proteins (2018)

The transmembrane docking of endoplasmic reticulum (ER) Ca<sup>2+</sup>-sensing STIM proteins with plasma membrane (PM) Orai Ca<sup>2+</sup> channels is a critical but poorly understood step in Ca<sup>2+</sup> signal generation. STIM1 protein dimers unfold to expose a discrete STIM-Orai activating region (SOAR1) that tethers and activates Orai1 channels within discrete ER-PM junctions. We reveal that each monomer within the SOAR dimer interacts independently with single Orai1 subunits to mediate cross-linking between Orai1 channels. Superresolution imaging and mobility measured by fluorescence recovery after photobleaching reveal that SOAR dimer cross-linking leads to substantial Orai1 channel clustering, resulting in increased efficacy and cooperativity of Orai1 channel function. A concatenated SOAR1 heterodimer containing one monomer point mutated at its critical Orai1 binding residue (F394H), although fully activating Orai channels, is completely defective in cross-linking Orai1 channels. Importantly, the naturally occurring STIM2 variant, STIM2.1, has an eight-amino acid insert in its SOAR unit that renders it functionally identical to the F394H mutant in SOAR1. Contrary to earlier predictions, the SOAR1-SOAR2.1 heterodimer fully activates Orai1 channels but prevents cross-linking and clustering of channels. Interestingly, combined expression of full-length STIM1 with STIM2.1 in a 5:1 ratio causes suppression of sustained agonist-induced Ca<sup>2+</sup> oscillations and protects cells from Ca<sup>2+</sup> overload, resulting from high agonist-induced Ca<sup>2+</sup> release. Thus, STIM2.1 exerts a powerful regulatory effect on signal generation likely through preventing Orai1 channel cross-linking. Overall, STIM-mediated cross-linking of Orai1 channels is a hitherto unrecognized functional paradigm that likely provides an organizational microenvironment within ER-PM junctions with important functional impact on Ca<sup>2+</sup> signal generation.
Characteristics of Human Intestinal Acid Sialidase (1987)

With methylumbelliferyl-N-acetyl-neuraminic acid (MU-NANA) as substrate, acid sialidase was determined in intestinal biopsies of children. The enzyme has an acid pH optimum, a Km value of 4 mmol/l and a pronounced thermal lability which can be partially prevented by the addition of albumin. N-acetyl-neuraminic acid (NANA) and derivatives as well as other glycoprotein and oligosaccharide sialidase substrates inhibit sialidase whereas gangliosides have no effect. This could be an indication that intestinal MU-NANA sialidase is different from ganglioside sialidase as has been reported for many other tissues.
Phosphine-Catalyzed Dual Umpolung Domino Michael Reaction: Facile Synthesis of Hydroindole- and Hydrobenzofuran-2-Carboxylates (2018)

A highly atom-economical, chemoselective, and stereoselective Lewis base (LB)-catalyzed dual umpolung domino Michael reaction between cyclohexadienones and alkynyl esters has been developed. PPh3, as a LB catalyst, afforded either the hydroindole-2-carboxylates or hydrobenzofuran-2-carboxylates 3 as a single diastereomer in high yields (up to 89%). An obtained product could be easily transformed to a (S*,S*,R*)-octahydroindole-2-carboxylic acid ((S*,S*,R*)-Oic) analogue.
Environmental Instability and Degradation of Single‐ and Few‐Layer WTe2 Nanosheets in Ambient Conditions (2016)

The ambient environmental instability and degradation mechanism of single- and few-layer WTe<sub>2</sub> are investigated. Oxidation of W and Te atoms appears to be a main reason for degradation. Single-layer samples' Raman signals disappear within 20 min in air. Few-layer WTe<sub>2</sub> exhibits saturating degradation behavior: only the top layer WTe<sub>2</sub> is oxidized; the degraded layer can protect inner layers from further degradation.
Finding Pulsars in Real-Time (2015)

Finding new pulsars has always been a challenging problem, but this challenge is nowadays exacerbated by the increasing data rates of modern radio telescopes. Because of these increased data rates, traditional approaches to searching, based on storing data for off-line processing, are becoming unfeasible. Therefore, we propose a new pulsar searching pipeline that, by exploiting high-performance computing techniques, is able to process observational data in real-time. To achieve the real-time goal we parallelized all the steps of the pipeline to run on many-core accelerators, and used auto-tuning to adapt and optimize the pipeline for different platforms, telescopes, and searching parameters. In this paper, we test our pipeline on three different platforms: two Graphics Processing Units from AMD and NVIDIA, and an Intel Xeon Phi. Furthermore, we test it on three different scenarios, based on the operational parameters of three state-of-the-art telescopes. Results show that our pipeline can adapt to all tested platforms and scenarios, and achieves real-time performance and linear scalability. Because power consumption is a main concern for radio telescopes, and will be the main bottleneck for the construction of the Square Kilometer Array, we also measure the power consumed by our pipeline. By comparing the results obtained on many-core accelerators with the results obtained using a traditional multi-core CPU, we conclude that the accelerators can provide up to a factor 8 improvement in execution time, and up to a factor 6 reduction in power consumption.
Identification ofrpoBCGenes Encoding for β and β′ Subunits of RNA Polymerase in a Deep-Sea Piezophilic Bacterium,Shewanella violaceaStrain DSS12 (2005)

RNA polymerase from cells of the deep-sea bacterium Shewanella violacea DSS12 was purified using three chromatographic steps. An in vitro transcription assay indicated that the purified enzyme was sigma(70) containing RNA polymerase. The enzyme activity was inhibited in the presence of rifampicin when the sensitive domain was targeted. The rpoBC genes encoding for the beta and beta' subunits of RNA polymerase were cloned and their nucleotide sequences determined. Expression plasmids, designated pQSVB and pQSVC, to overproduce these proteins were constructed, and the proteins were purified using a Ni(2+) affinity column. In vitro reconstitution using all proteins for the holoenzyme (alpha, beta, beta', sigma(70)) was carried out and the activity of the recombinant RNA polymerase was detected.
Some Strongly Basic Derivatives of (+)- and (-)-1-Hydroxy-2-aminobutane1 (1954)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSome Strongly Basic Derivatives of (+)- and (-)-1-Hydroxy-2-aminobutane1Ralph B. Fearing and Sidney W. FoxCite this: J. Am. Chem. Soc. 1954, 76, 17, 4382–4385Publication Date (Print):September 1, 1954Publication History Published online1 May 2002Published inissue 1 September 1954https://pubs.acs.org/doi/10.1021/ja01646a033https://doi.org/10.1021/ja01646a033research-articleACS PublicationsRequest reuse permissionsArticle Views316Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Temperature-dependent development and reproduction of the boll weevil (Coleoptera: Curculionidae) (2005)

Abstract Effects of temperature on development, survival, and fecundity of boll weevil, Anthonomus grandis grandis Boheman, were assessed at 10, 11, 12, 15,20,25,30,35,45, and 46 °C; 65% relative humidity; and a photoperiod of 13:11 (L: D) h. The mortality of boll weevil immature stages was 100% at 12°C and decreased to 36.4% as the temperature increased to 25°C. When the temperature increased from 30 °C to 45 °C, the mortality of weevils also increased from 50.1% to 100%. From 15°C to 35°C, the bollweevilpreimaginal development rate was linearly related to temperature. The average development time of total boll weevil immature lifestages decreased 3.6-fold and the preovipositional period decreased 3.3-fold when the temperature was increased from 15°C to 30°C. The lower threshold for development was estimated at 10.9, 6.6, 7.0, and 9.0 °C for eggs, larval, pupal, and total immature stages, respectively, with total thermal time requirement to complete immature stages of 281.8 DD (degree day) (15°C) and 247.8 DD (35 °C). At 1LC and 46°C, weevil females did not oviposit. Longevity of adult females decreased 4.6-fold with increasing temperatures from 15°C to 35°C. Fecundity increased with increasing temperatures up to 30°C and significantly decreased thereafter. These findings will be useful in creating a temperature-based degree-day model for predicting the occurrence of key life stages in the field. An accurate predictor of a pest's development can be very important in determining sampling protocols, timing insecticide applications, or implementing an integrated pest management control strategy targeting susceptible life stages.
Simulation of the Influence of Reactant Depletion on Nucleation Rate in Electrodeposition (2004)

Numerical simulations are used to study the electrochemical nucleation of hemispherical particles followed by diffusion-controlled growth. The impact of reactant depletion on nucleation rate is considered by introduction of a concentration-dependent rate law. The effect is only important when the nucleation rate is comparable to or slower than the growth rate. For instantaneous nucleation, particles are born before surface depletion is significant. Simulated current transients and particle statistics are discussed and compared to previous experimental and theoretical attempts to address the problem. A concentration-dependent nucleation rate may have a relatively small impact on the predicted current transient but may have a significant effect on particle density and size distribution. © 2004 The Electrochemical Society. All rights reserved.
Core HTML5 Canvas: Graphics, Animation, and Game Development (2012)

Free chapters and the book's code are available at CoreHTML5Canvas.comOne of HTML5's most exciting features, Canvas provides a powerful 2D graphics API that lets you implement everything from word processors to video games. In Core HTML5 Canvas, best-selling author David Geary presents a code-fueled, no-nonsense deep dive into that API, covering everything you need to know to implement rich and consistent web applications that run on a wide variety of operating systems and devices. Succinctly and clearly written, this book examines dozens of real-world uses of the Canvas API, such as interactively drawing and manipulating shapes, saving and restoring the drawing surface to temporarily draw shapes and text, and implementing text controls. You'll see how to keep your applications responsive with web workers when you filter images, how to implement smooth animations, and how to create layered, 3D scrolling backgrounds with parallax. In addition, you'll see how to implement video games with extensive coverage of sprites, physics, collision detection, and the implementation of a game engine and an industrial-strength pinball game. The book concludes by showing you how to implement Canvas-based controls that you can use in any HTML5 application and how to use Canvas on mobile devices, including iOS5. This authoritative Canvas reference covers The canvas element--using it with other HTML elements, handling events, printing a canvas, and using offscreen canvases Shapes--drawing, dragging, erasing, and editing lines, arcs, circles, curves, and polygons; using shadows, gradients, and patterns Text--drawing, positioning, setting font properties; building text controls Images--drawing, scaling, clipping, processing, and animating Animations--creating smooth, efficient, and portable animations Sprites--implementing animated objects that have painters and behaviors Physics--modeling physical systems (falling bodies, pendulums, and projectiles), and implementing tweening for nonlinear motion and animation Collision detection--advanced techniques, clearly explained Game development--all aspects of game development, such as time-based motion and high score support, implemented in a game engine Custom controls--infrastructure for implementing custom controls; implementing progress bars, sliders, and an image panner Mobile applications--fitting Canvas apps on a mobile screen, using media queries, handling touch events, and specifying iOS5 artifacts, such as app icons Throughout the book, Geary discusses high-quality, reusable code to help professional developers learn everything they really need to know, with no unnecessary verbiage. All of the book's code and live demonstrations of key techniques are available at CoreHTML5Canvas.com.
Upstream regulatory region of the human embryonic β-like globin gene, ϵ (1994)

The sequence of the human embryonic beta-like globin gene (epsilon) upstream regulatory region has been reported previously. In the course of our own work, we found a significant number of discrepancies between our sequence and the data base sequence, which we show here to contain large clusters of errors within functional epsilon-globin regulatory domains.
Magnetism of neutron-damaged alpha-quartz (1986)

Abstract Static magnetic susceptibilities have been measured on an α-quartz single crystal that had been irradiated with fast neutrons. Above 65 K, the radiation-induced paramagnetism obeys the Curie law, indicating the presence of non-interacting centres. The low-temperature measurements result in a field-dependent susceptibility comparable to the effect of the Brillouin saturation of non-interfacing centres. The average moment per centre, however, is higher than the one due to the spin only of single unpaired electrons, pointing to ferromagnetically coupled electron pairs. When the calculated susceptibility values, as obtained from the derived moments and concentrations using the Brillouin theory, are subtracted from the measured data, then the differences behave—over the whole temperature range—as the susceptibility of antiferromagnetically coupled electrons. On the same sample also, low-temperature 20.9 GHz ESR measurements have been carried out. The major resonance line is attributed to the E’ centre. The general behaviour clearly corroborates the presence of interactions; the effect does not show anisotropy.