gebhart/patrepeval huggingface dataset:
Fatty acid oxidation by lymphocytes (1994)

Conference Article| May 01 1994 Fatty acid oxidation by lymphocytes PARVEEN YAQOOB; PARVEEN YAQOOB 1Deparment of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K. Search for other works by this author on: This Site PubMed Google Scholar ERIC A. NEWSHOLME; ERIC A. NEWSHOLME 1Deparment of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K. Search for other works by this author on: This Site PubMed Google Scholar PHILIP C. CALDER PHILIP C. CALDER 1Deparment of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1994) 22 (2): 116S. https://doi.org/10.1042/bst022116s Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation PARVEEN YAQOOB, ERIC A. NEWSHOLME, PHILIP C. CALDER; Fatty acid oxidation by lymphocytes. Biochem Soc Trans 1 May 1994; 22 (2): 116S. doi: https://doi.org/10.1042/bst022116s Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: Con A, Concanavalin A, DNA, deoxyribosenucleic acid, PUFA, polyunsaturated fatty acids This content is only available as a PDF. © 1994 Biochemical Society1994 Article PDF first page preview Close Modal You do not currently have access to this content.
Learning to Coordinate with Coordination Graphs in Repeated Single-Stage Multi-Agent Decision Problems (2018)

Learning to coordinate between multiple agents is an important problem in many reinforcement learning problems. Key to learning to coordinate is exploiting loose couplings,i.e.,conditional independences between agents. In this paper we study learning in repeated fully cooperative games, multi-agent multi-armed bandits (MAMABs), in which the expected rewards can be expressed as a coordination graph. We propose multi-agent upper confidence exploration (MAUCE), a new algorithm for MAMABs that exploits loose couplings, which enables us to prove a regret bound that is logarithmic in the number of arm pulls and only linear in the number of agents.We empirically compare MAUCE to sparse cooperative Q-learning, and a state-of-the-art combinatorial bandit approach, and show that it performs much better on a variety of settings,including learning control policies for wind farms.
The World of Stem Cell Therapy: Anonymity is not an Option. (2007)

Although it remains poised to become one of the biggest biotech markets, stem cell therapy continues to operate under a microscope. Investigators have a lot of explaining to do - both to the public and private payers - why it makes sense to cover their treatments.
A Small Molecule Swertisin fromEnicostemma littoraleDifferentiates NIH3T3 Cells into Islet-Like Clusters and Restores Normoglycemia upon Transplantation in Diabetic Balb/c Mice (2013)

Aim. Stem cell therapy is one of the upcoming therapies for the treatment of diabetes. Discovery of potent differentiating agents is a prerequisite for increasing islet mass. The present study is an attempt to screen the potential of novel small biomolecules for their differentiating property into pancreatic islet cells using NIH3T3, as representative of extra pancreatic stem cells/progenitors. Methods. To identify new agents that stimulate islet differentiation, we screened various compounds isolated from Enicostemma littorale using NIH3T3 cells and morphological changes were observed. Characterization was performed by semiquantitative RT-PCR, Q-PCR, immunocytochemistry, immunoblotting, and insulin secretion assay for functional response in newly generated islet-like cell clusters (ILCC). Reversal of hyperglycemia was monitored after transplanting ILCC in STZ-induced diabetic mice. Results. Among various compounds tested, swertisin, an isolated flavonoid, was the most effective in differentiating NIH3T3 into endocrine cells. Swertisin efficiently changed the morphology of NIH3T3 cells from fibroblastic to round aggregate cell cluster in huge numbers. Dithizone (DTZ) stain primarily confirmed differentiation and gene expression studies signified rapid onset of differentiation signaling cascade in swertisin-induced ILCC. Molecular imaging and immunoblotting further confirmed presence of islet specific proteins. Moreover, glucose induced insulin release (in vitro) and decreased fasting blood glucose (FBG) (in vivo) in transplanted diabetic BALB/c mice depicted functional maturity of ILCC. Insulin and glucagon expression in excised islet grafts illustrated survival and functional integrity. Conclusions. Rapid induction for islet differentiation by swertisin, a novel herbal biomolecule, provides low cost and readily available differentiating agent that can be translated as a therapeutic tool for effective treatment in diabetes.
Adaptive regularized multichannel Blind deconvolution using alternating minimization (2015)

Multichannel blind deconvolution is an ill posed problem where regularizers plays an important role. Adaptive regularization is used to obtain better quality restored image. This adds penalty weighted term along with image regularizer. The Isotropic TV image regularizers have chosen along with directional priors which preserves the over smoothing of the edges when compare to horizontal and vertical priors, thereby improving the Peak Signal to Noise Ratio(PSNR) of the reconstructed image. The Blind deconvolution problem can be solved using Alternating minimization algorithm as it is best suited for two unknown variables. The formulation of blind deconvolution can be l <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> regularized optimization and geometry can be l <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> . It results in hard optimization problem. The minimization step alternates between two sub optimization problems and this can be solve efficiently using Augmented Lagrangian method(ALM), where each iteration undergoes Bregman variable splitting or iterative method. This converted unconstrained problem in to constrained. This method can be applicable to medical images such as X Ray in order to reduce the amount of rays penetrating in to the body and to observe more details.
System engineering for collaborative data management systems: Application to design / simulation loops (2006)

This doctoral thesis analyses the evolution of digital technologies and methods for data management systems applied to the context of extended enterprise. Nowadays, in the aeronautics' product development context, projects are evolving towards large-scale partnerships. A large amount of data created for this product development has then to be processed and managed in a coherent way between the different partners. Indeed, the need of enabling data exchange and integration has evolved from the simple file to the management of an integrated design context. This way, closer integration between data created and managed is identified as a factor to shorten the development cycle. This integration involves as well the integration of the overall data created all along the project as the structure to support processes. This PhD dissertation then presents the study of a centralised architecture to ensure the multi-partnership and multi-view engineering by providing a common referential for data semantic. The use of standards in this study also complies with a high level of interoperability issues in terms of consistency and easy migration of data between engineering systems and activities.
Neutralization of Fibroblast Growth Factor-2 Reduces Intraarticular Adhesions (2001)

Adhesion is a serious complication after trauma or surgery. Because adhesion formation is essentially a fibrogenetic process, a series of growth factors are assumed to be involved in its development. If this is true, it may be possible that inhibition of the growth factor activity suppresses adhesion formation. The current study was conducted to verify this hypothesis on fibroblast growth factor-2 using an intraarticular adhesion model in the rabbit knee. Forty Japanese White rabbits were used. They were divided randomly into five groups of eight animals, and in three of them, activity of endogenous fibroblast growth factor-2 was suppressed locally by a neutralizing antibody. The remaining two groups served as controls, and formation of adhesions was evaluated 4 weeks after surgery. The results showed that the administration of the antibody reduced the extent of adhesions macroscopically, whereas histologic observation and collagen content measurement suggested the adhesion tissue was not affected significantly. Corresponding to the macroscopic findings, contraction of the knee was improved in the antibody groups. The findings showed that suppression of fibroblast growth factor-2 activity reduces adhesions. It is expected that control of the cytokine activity may become a novel method for reducing adhesions.
Speciation of Ruthenium as a Reduction Promoter of Silica-Supported Co Catalysts: A Time-Resolved in Situ XAS Investigation (2015)

Complete reduction of the metal phase in cobalt-containing catalysts is often difficult to reach and can be promoted by a small amount of noble metals. Because these costly promoters are introduced in a very low quantity, their speciation and their chemical interaction with cobalt have seldom been studied in detail. We present here a time-resolved in situ X-ray absorption spectroscopy investigation of the speciation of ruthenium, used as a reduction promoter of cobalt, throughout the preparation of Co/SiO2 catalysts. In the cobalt(II) nitrate impregnation solution, ruthenium is detected as hydrated Ru(OH)4 short-chain oligomers that are deposited on silica upon drying. Co3O4 forms during calcination in air and catalyzes the elimination in the gas phase of 60% of Ru. The addition of a polyol, sorbitol, in the impregnation solution stabilizes the whole of Ru on the catalyst. Upon calcination, Ru(IV) ions are inserted inside Co3O4 nanoparticles. Reduction of the oxidic phase takes place in two distinct steps, at approximately the same temperatures regardless of the ruthenium content: first to Ru(III)-containing CoO nanoparticles (Ru ions modifying the intrinsic electronic properties of the oxidic nanoparticles); then to bimetallic Co nanoparticles containing Ru(0) atoms, via an autocatalytic process. Ru loadings as low as 0.2 wt % are sufficient to afford complete reduction of cobalt. Close association between Ru and Co from the beginning of the synthesis is thus necessary for a maximum promoting effect.
Inside Microsoft Dynamics AX 4.0 (2006)

Dig into the architecture and internals of Microsoft Dynamics AXwith firsthand insights from the team who designed and developed it. Deepen your knowledge of the underlying frameworks, components, and toolsand get best-practice guidance to customize and extend your own high-performance solutions. Discover how to: Work with MorphX application-modeling tools and X++ code Exploit built-in workflow infrastructure to simplify process automation Use Enterprise Portal and ASP.NET to build rich, role-based Web portals See how reporting components work together for better business intelligence Execute complex batch jobs with greater control and reliability Learn how the runtime implements configuration and security Walk through integration scenarios and technologies Create and expose services to external applications Optimize application performance and extensibility
Flexible parylene actuator for micro adaptive flow control (2002)

This paper describes the first flexible parylene electrostatic actuator valves intended for micro adaptive flow control for the future use on the wings of micro-air-vehicle (MAV). The actuator diaphragm is made of two layers of parylene membranes with offset vent holes. Without electrostatic actuation, air can move freely from one side of the skin to the other side through the vent holes. With actuation, these vent holes are sealed and the airflow is controlled. The membrane behaves as a complete diaphragm. We have successfully demonstrated this function using a 2-mm/spl times/2-mm parylene diaphragm electrostatic actuator valves. This work also includes the novel anti-stiction technology that is crucial to make such large-area parylene actuator diaphragm with the combined use of anti-stiction posts, self-assembled monolayers (SAM), surface roughening, and bromine trifluoride (BrF/sub 3/) dry etching. With the help of SAM treatment, the operating voltage is lowered from 30 volts to 13 volts. The load deflection method is then used to measure the effective thickness of the composite diaphragm. The flexible parylene diaphragm can be deflected up to 100 /spl mu/m when 150 Torr of pressure is applied. The result is fitted into a theoretical model and yields an effective thickness of 5.9 /spl mu/m, which is agreeable with the actual thickness of 5.6 /spl mu/m, thus proves the functionality of the device.
Modified silicone rubbers for fabrication and contacting of flexible suspended membranes of n-/p-GaP nanowires with single-walled carbon nanotube transparent contact (2020)

Abstract This work proposes new chemical and mechanical materials and techniques for III-V semiconductor NW/silicone membrane formation and optoelectronic device fabrication. Molecular beam epitaxy (MBE)-synthesized n-, p- and i-GaP NWs were encapsulated by introduced G-coating method into synthesized polydimethylsiloxane- graft -polystyrene and released from the Si growth substrate. The fabricated membranes were contacted with different materials including single-walled carbon nanotubes or ferrocenyl-containing polymethylhydrosiloxane with and without multi-walled carbon nanotubes doping. The electrical connection of the fabricated membranes was verified by electron beam induced current (EBIC) spectroscopy. The developed methods and materials can be applied for fabrication of high quality flexible inorganic optoelectronic devices.
Polychlorinated Biphenyl Reductive Dechlorination by Vitamin B12s:  Thermodynamics and Regiospecificity (1999)

Microbial reductive dechlorination reactions play an important role in determining the environmental fate of polychlorinated biphenyls (PCBs), especially for PCB congeners with more than four chlorines. Powerful chemical catalysts such as vitamin B12s provide an effective tool for the study of reductive dechlorination reactions. The reductive dechlorination of PCBs by titanium(III) citrate-reduced vitamin B12s was studied in batch reactors. Long-term experiments demonstrated reductive dechlorination of aqueous and sediment-sorbed 2,3,4,5,6-pentachlorobiphenyl (2,3,4,5,6-PeCB) to tetra-, tri-, di-, and monochlorobiphenyl products. Approximately 10% chlorine removal was observed in 36 days in aqueous experiments at 20 °C; the sediment experiment showed 40% chlorine removal in 42 days at 30 °C. Nearly all possible intermediates were produced and reductively dechlorinated, with no apparent accumulation of individual congeners. Short-term experiments were conducted to determine the pathway for vitamin B12s-catalyzed reductive dechlorination of aqueous 2,3,4,5,6-PeCB and its dechlorinated products; relative product distributions were measured for all possible tetra- and trichlorobiphenyl reductive dechlorination reactions. Theoretical product distributions based on free energies of formation agreed with observed product distributions for short- and long-term experiments. Reductive dechlorination was favored at positions with adjacent chlorines; on average, chlorines were removed equally from ortho, meta, and para positions.
Is protein-energy intake adequate during dialysis treatment in hemodialysis patients ? (2012)

Protein-energy wasting (PEW) is a strong predictor of mortality in patients with chronic kidney disease. Although PEW is caused by non nutritional conditions, research indicates that nutritional support that targets adequate protein intake improves outcome. During dialysis therapy in-centre meals and snacks are provided. The question is whether these meals provide adequate protein and energy intake considering external (at home) consumed meals? Indirect calorimetry and physical activity Level (PAL) were performed to provide daily energy needs. Three day food record was performed for 2 dialysis days and 1 non dialysis day. Statistical analysis was done using SPSS19, paired T-test was used to detect significant differences (p<0.05). Mean and standard deviations are given. In the VU University Medical Centre 20 hemodialysis patients (12 men), mean age 58±3 year, BMI (kg/m2) 26±6 were enrolled. Protein intake was 82% of protein requirements (68+21 vs 83+12 g/d, p<0.001). Energy intake was 87% of energy requirements (1636+483 vs 1878±244 kcal/d, p<0.001). Protein intake on dialysis days was 72±19 vs 65±29 g/d on non-dialysis days (p<0.142). Energy intake on dialysis days was 1786±486 vs 1570±609 kcal/d on non-dialysis days (p<0.031). Dinner or lunch provided 39% of the daily energy needs, which is adequate according to a national guideline; and 35% of daily protein needs, which is lower than healthy Dutch adults. Protein and energy intake of hemodialysis patients is lower than their daily needs. On non dialysis days intake is even lower than on dialysis days. The meals consumed during dialysis treatment contain enough energy but not enough protein to meet requirements.
Mechanical stimulation of osteopontin mRNA expression and synthesis in bone cell cultures (1997)

We have shown earlier that mechanical stimulation by intermittent hydrostatic compression (IHC) promotes alkaline phosphatase and procollagen type I gene expression in calvarial bone cells. The bone matrix glycoprotein osteopontin (OPN) is considered to be important in bone matrix metabolism and cell-matrix interactions, but its role is unknown. Here we examined the effects of IHC (13 kPa) on OPN mRNA expression and synthesis in primary calvarial cell cultures and the osteoblast-like cell line MC3T3-E1. OPN mRNA expression declined during control culture of primary calvarial cells, but not MC3T3-E1 cells. IHC upregulated OPN mRNA expression in late released osteoblastic cell cultures, but not in early released osteoprogenitor-like cells. Also, in both proliferating and differentiating MC3T3-E1 cells, OPN mRNA expression and synthesis were enhanced by IHC, differentiating cells being more responsive than proliferating cells. These results suggest a role for OPN in the reaction of bone cells to mechanical stimuli. The severe loss of OPN expression in primary bone cells cultured without mechanical stimulation suggests that disuse conditions down-regulate the differentiated osteoblastic phenotype.
Remaking Eden. Cloning and beyond in a Brave New World (2000)

Exploring in depth one of the most topical subjects of current affairs, this book explains the science of embryology, exploring what science can and will be able to do to affect the natural processes, through a series of individual stories, both contemporary and imagined.
PREFACE (1977)

ADVERTISEMENT RETURN TO BOOKPREVPrefaceNEXTPREFACEROBERT E. FEENEYROBERT E. FEENEYDavis, Calif. January 1976More by ROBERT E. FEENEY and JOHN R. WHITAKERJOHN R. WHITAKERDavis, Calif. January 1976More by JOHN R. WHITAKERDOI: 10.1021/ba-1977-0160.pr001 This publication is free to access through this site. Learn MorePublication Date (Print):June 1, 1977Publication History Published online22 July 2009Published inprint 1 June 1977Request reuse permissions Copyright © 1977 AMERICAN CHEMICAL SOCIETY. This publication is available under these Terms of Use. Food Proteinspp vii-viiiAdvances in ChemistryVol. 160ISBN13: 9780841203396eISBN: 9780841223417Chapter Views100Citations-LEARN ABOUT THESE METRICSChapter Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (271 KB) Get e-Alerts
Proteome of cell wall-extracts from pathogenic Paracoccidioides brasiliensis: Comparison among morphological phases, isolates, and reported fungal extracellular vesicle proteins (2014)

We identified non-covalently linked cell wall proteins from Paracoccidioides brasiliensis yeasts and mycelia, with focus on the yeast pathogenic phase, and correlated them with reported fungal extracellular vesicle proteins. We studied isolates Pb3 and Pb18, which evoke distinct patterns of experimental paracoccidioidomycosis and represent two phylogenetic groups. Proteins were extracted mildly with dithiothreitol, trypsinized, and peptides analyzed by liquid chromatography coupled to high-resolution mass spectrometry. Among 132 yeast-exclusive sequences, 92 were Pb18-exclusive. About 80% of total proteins were classified as secretory, mostly showing non-conventional signals. Extracellular vesicular transportation could be involved, since 60% had orthologs reported in fungal extracellular vesicles.
Web-key: Mashing with Permission (2008)

Mashups, web applications that interact with other web applications, are receiving increasing developer interest and providing users with valuable new functionality. When one or more of the interacting applications have access control requirements, many design challenges arise. Failure to meet these challenges brings unnecessary risk to the user. Addressing the challenges using a poorly suited technique can add significant complexity to both the application code and the user interface, all while not reducing risk to the user. This paper introduces the web-key, an
Depth resolved hyperspectral imaging spectrometer based on structured light illumination and Fourier transform interferometry (2014)

A depth resolved hyperspectral imaging spectrometer can provide depth resolved imaging both in the spatial and the spectral domain. Images acquired through a standard imaging Fourier transform spectrometer do not have the depth-resolution. By post processing the spectral cubes (x, y, λ) obtained through a Sagnac interferometer under uniform illumination and structured illumination, spectrally resolved images with depth resolution can be recovered using structured light illumination algorithms such as the HiLo method. The proposed scheme is validated with in vitro specimens including fluorescent solution and fluorescent beads with known spectra. The system is further demonstrated in quantifying spectra from 3D resolved features in biological specimens. The system has demonstrated depth resolution of 1.8 μm and spectral resolution of 7 nm respectively.