gebhart/patrepeval huggingface dataset:
[Philadelphia chromosome-positive acute lymphoblastic leukemia relapsing with an anterior chamber lesion of the eye]. (2019)

A 48-year-old Filipino woman underwent umbilical cord blood stem cell transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia under non-remission status. Left aqueous humor puncture was performed owing to the development of left eye pain and exacerbation of anterior eye chamber inflammation 72 days after the transplantation; this revealed the relapse of leukemia in the anterior chamber. Subsequently, the patient tested positive for peripheral blood minimal residual disease. Therefore, doctors should take note that anterior chamber disease may appear as a non-typical relapse of leukemia.
Human blood plasma biomarkers of diet and weight loss among centrally obese subjects in a New Nordic Diet intervention (2023)

The main plasma metabolites associated with NND were acetate, methanol and 3-hydroxybutyrate. The metabolic changes associated with the NND-driven weight loss are mostly pronounced in energy and lipid metabolism.
Novel approaches for the development of direct KRAS inhibitors: structural insights and drug design (2022)

After the initial success in targeting the mutant KRAS G12C variants, the search has been shifted to address the challenges concerning the resistance and efficacy of small molecule KRAS inhibitors. However, the contribution of other KRAS mutations at G12V, G13C, and G13D variants causing cancers is much higher than the mutations at G12C. In view of this aspect, specific attention is required to target all other mutations as well. Accordingly, for the development of KRAS targeted therapies, the design of small molecule inhibitors that can inhibit KRAS signaling and as well as target inhibition of other signaling pathways like RAS-SOS and RAS-PI3K has to be explored extensively.
Alternative splicing of HLA-G transcripts yields proteins with primary structures resembling both class I and class II antigens. (1992)

We have investigated HLA-G mRNA expression in cells and tissues expressing the gene. This analysis has demonstrated that the HLA-G primary transcript is alternatively spliced to yield at least three distinct mature mRNAs. Sequencing of the transcripts has shown that the largest mRNA is essentially that previously characterized, encoding a leader sequence, three external domains, a transmembrane region, and a cytoplasmic sequence. Of the two smaller messages, a 900-base mRNA does not include exon 3, resulting in a predicted protein sequence with the alpha 1 and alpha 3 external domains joined. The smallest mRNA results from splicing out exons 3 and 4, connecting the alpha domain directly to the transmembrane sequence. Alternative splicing of HLA-G mRNA was found in placental tissues and in eye tissue as well as in HLA-G-transfected cell lines. In term placental tissue the smallest mRNA appeared to be more abundant than the full-length form, while in a cell line derived from an earlier developmental stage the larger form predominated. Immunoprecipitation of [35S]methionine-labeled cell lysates showed that three different HLA-G proteins were present in transfected cells, with sizes corresponding to those predicted from the three alternative mRNA sequences. These findings are discussed in terms of potential functions of the alternative HLA-G proteins.
Assessing Software Service Quality and Trustworthiness at Selection Time (2010)

The integration of external software in project development is challenging and risky, notably because the execution quality of the software and the trustworthiness of the software provider may be unknown at integration time. This is a timely problem and of increasing importance with the advent of the SaaS model of service delivery. Therefore, in choosing the SaaS service to utilize, project managers must identify and evaluate the level of risk associated with each candidate. Trust is commonly assessed through reputation systems; however, existing systems rely on ratings provided by consumers. This raises numerous issues involving the subjectivity and unfairness of the service ratings. This paper describes a framework for reputation-aware software service selection and rating. A selection algorithm is devised for service recommendation, providing SaaS consumers with the best possible choices based on quality, cost, and trust. An automated rating model, based on the expectancy-disconfirmation theory from market science, is also defined to overcome feedback subjectivity issues. The proposed rating and selection models are validated through simulations, demonstrating that the system can effectively capture service behavior and recommend the best possible choices.
Strategic distribution of seeds to support diffusion in complex networks (2018)

Usually, the launch of the diffusion process is triggered by a few early adopters-i.e., seeds of diffusion. Many studies have assumed that all seeds are activated once to initiate the diffusion process in social networks and therefore are focused on finding optimal ways of choosing these nodes according to a limited budget. Despite the advances in identifying influencing spreaders, the strategy of activating all seeds at the beginning might not be sufficient in accelerating and maximising the coverage of diffusion. Also, it does not capture real scenarios in which marketing campaigns continuously monitor and support the diffusion process by seeding more nodes. More recent studies investigate the possibility of activating additional seeds as the diffusion process goes forward. In this work, we further examine this approach and search for optimal ways of distributing seeds during the diffusion process according to a pre-allocated seeding budget. Theoretically, we show that a universally best solution does not exist, and we prove that finding an optimal distribution of supporting seeds over time for a particular network is an NP-hard problem. Numerically, we evaluate several seeding strategies on different networks regarding maximising the coverage and minimising the spreading time. We find that each network topology has a best strategy given some spreading parameters. Our findings can be crucial in identifying the best strategies for budget allocation in different scenarios such as marketing or political campaigns.
Heparanase: A New Metastasis-Associated Antigen Recognized in Breast Cancer Patients by Spontaneously Induced Memory T Lymphocytes (2006)

Increased expression and secretion of heparanase (Hpa) by tumor cells promotes tumor invasion through extracellular matrices, tissue destruction, angiogenesis, and metastasis. Here, we show the existence in breast cancer patients of Hpa-specific T lymphocytes by fluorescence-activated cell sorting flow cytometry using Hpa peptide-MHC class I tetramers. We furthermore show memory T-cell responses in a high proportion of breast cancer patients to Hpa-derived HLA-A2-restricted peptides, leading to production of IFN-gamma and to generation of antitumor CTLs lysing breast cancer cells. Such CTLs recognized endogenously processed respective Hpa peptides on Hpa-transfected and Hpa-expressing untransfected breast carcinoma cells. According to these results and to the fact that such cells were not found in healthy people, Hpa seems to be an attractive new tumor-associated antigen and its HLA-A2-restricted peptides ought to be good candidates for peptide vaccination to reactivate memory immune responses to invasive and metastatic cancer cells.
The Conard-Pyle Co., February 9 / (1929)

knowledge, policies, or practices.
Thermo-responsive discotic nematic hydrogels (2013)

We synthesized a novel thermo-responsive discotic nematic hydrogel. This liquid crystalline polymer nanocomposite was fabricated using extremely high-aspect-ratio (ξ = diameter/thickness ∼ 103) zirconium phosphate (ZrP) nano-sheets embedded into a polymeric network. These nano-sheets were immersed into a solution of constituent monomers of N-isopropylacrylamide (NIPAm) and acrylamide (AAm) with a subsequent polymerization in situ to obtain a hydrogel embedded with the nematic liquid crystal of the nano-sheets. We analyzed the effect of initiator (APS) and catalyst (TEMED) concentration on the nematic domains at ZrP nano-sheet volume fractions (ϕZrP) near the isotropic–nematic (I–N) transition. The mixing during hydrogel preparation allowed the aligning of the nano-sheets into highly ordered domains, which were eventually disturbed by the effect of APS and TEMED on the polymer matrix. The effect of ZrP nano-sheet concentration and temperature on the nematic hydrogels was also studied. By increasing the temperature above the LCST of PNIPAm, the hydrogels entered into a hydrophilic-to-hydrophobic transition. Interestingly, hydrogels containing ZrP nano-sheets presented increased hydrogel water retention. In addition, we observed that the variation of the nematic ordering (S2) and ϕZrP within the system manipulated the birefringent color patterns of the hydrogels. Finally, a nematic hydrogel placed into a thin-rectangular capillary from 298 K to 333 K presented edge-wrinkling. An isotropic-to-nematic transition guided by the increment in the ZrP nano-sheet nematic ordering was observed at a nano-sheet concentration slightly below the isotropic concentration (ϕI).
Interleukin‐13 receptor alpha2 is a novel therapeutic target for human adrenocortical carcinoma (2012)

The current results indicated that IL13Rα2 is overexpressed in ACC and regulates cell invasion and proliferation. IL13Rα2 is a novel therapeutic target for the treatment of human ACC.
HIF in Vascular Development and Tumour Angiogenesis (2007)

Hypoxia stimulates angiogenesis through the up-regulation of vascular endothelial growth factor and other angiogenic cytokines. Members of the hypoxia-inducible factor (HIF) family of transcription factors play a central role in the cellular hypoxia response. To address the function of HIF signalling in physiological and pathological angiogenesis, we used a dominant-negative approach that interferes with the function of both HIF-1 and HIF-2. The expression of a dominant-negative HIF mutant in endothelial cells inhibited endothelial sprouting and disrupted cardiovascular development in mouse embryos, demonstrating that endothelial HIF function is essential for embryogenesis. However, the inhibition of HIF activity in tumour vessels accelerated the growth of experimental fibrosarcoma and osteosarcoma. The over-expression of prolyl hydroxylase domain protein 2 (PHD2), an enzyme that negatively regulates HIF stability, strongly reduced growth of LM8 osteosarcoma cells in vivo. Our results are in line with the complexity of HIF function and indicate that HIF inhibition might not be an ideal anti-tumour strategy.
Extending SIP authentication to exploit user credentials stored in existing authentication databases (2008)

The SIP protocol provides authentication and authorization of SIP requests through a challenge-response authentication scheme inherited by the HTTP protocol and named HTTP Digest Authentication. The current specification defines a particular algorithm for calculating the challenge response that uses the MD5 hash of a combination of user name, realm, and password. Unfortunately, a lot of authentication systems maintain the user credentials protected with a one-way function (usually a hash) in a way that is incompatible with the information required by the current HTTP Digest Authentication. Some examples are given by the mechanisms used for storing passwords by the Unix OS, LDAP servers, or other applications. In this paper, we propose to extends the original HTTP Digest Authentication by adding a new and flexible scheme that uses an arbitrary hash function and an arbitrary combination of various information such as user name, realm, password, salt, and/or other data. The proposed authentication scheme has been implemented within two testbeds in which a SIP UA authenticates itself with a remote proxy server (acting as authenticator) that uses respectively a LDAP server or a userspsila password file of a Joomla Content Management System.
Virtual Information Facility of the INFOPLEX Software Test Vehicle. Part II. (1982)

Abstract : This report describes the software design and implementation of the rear-end for the Virtual Information Facility of the INFOPLEX database computer. It is part of a major effort to develop a software simulation, STV, for the underlying architecture of INFOPLEX. The virtual information facility is a single level of operations situated within the Functional Hierarchy. It supports the use of virtual information, a virtual entity based on procedural relationships and derivations from physically recorded data. Upon completion, this facility will be integrated within the current implementation of the STV for the INFOPLEX Functional Hierarchy which lacks the support for virtual information processing.
Early evaluation of multicore systems soft error reliability using virtual platforms (2018)

The increasing computing capacity of multicore components like processors and graphics processing units (GPUs) offer new opportunities for embedded and high-performance computing (HPC) domains. The progressively growing computing capacity of multicore-based systems enables to efficiently perform complex application workloads at a lower power consumption compared to traditional single core solutions. Such efficiency and the ever-increasing complexity of application workloads encourage industry to integrate more and more computing components into the same system. The number of computing components employed in large-scale HPC systems already exceeds a million cores, while 1000-cores on-chip platforms are available in the embedded community.
Hierarchical fault tolerant control using component based models (2001)

This paper presents a hierarchical Fault Tolerant Control architecture using a component-based model of a complex system. In this model, components (actuators, sensors, linkages, etc.) are modeled individually with the interactions between components represented by an interconnection structure. The Fault Tolerant Control strategy has three levels to the hierarchy. The highest level encompases Fault Detection and Identification (FDI) to identify failure conditions. The middle level then redistributes the available control authority among healthy subsystems, calculates optimal control setpoints to maintain stability of the system, and adjusts local controller gains to boost system performance. The lowest level consists of the local subsystems and corresponding controllers. As an example, this approach is applied to a multi-tank process in the presence of a stuck actuator.
A Frequency- and Polarization-Reconfigurable Circular Cavity Antenna (2016)

The principle and experimental validation of a frequency- and polarization-reconfigurable antenna using switching PIN diodes is presented in this letter. The antenna is based on a center-fed circular cavity with switchable shorting vias along its outer edge. Turning a set of shorting vias on on one side and off on the other side creates a radiating slot with controllable length and location along the side wall of the cavity that results in different antenna resonance frequencies and polarizations. As a proof of concept, a particular realization of the antenna is designed that can change the linear polarization in six different angles and at five discrete frequencies (spanning more than one octave). Based on the proposed concept, quasi-continuous frequency- and polarization-reconfiguration is feasible using individual control of a large number of switching devices.
The efficacy of agents employed to prevent anastomotic recurrence in colorectal carcinoma. (1984)

Forty-eight of 72 surgeons canvassed in the South West of England (67%) routinely use an intraluminal cytotoxic agent to prevent suture-line recurrence following partial resection of the large bowel for cancer. The most popular agents are chlorhexidine-cetrimide preparations (n = 14), mercuric perchloride (12), povidone-iodine (7) and water (12); noxythiolin, sodium hypochlorite and silver nitrate are used occasionally. The mean duration of treatment is 2 minutes. When assayed for cytotoxity against tumour cells freshly prepared from human colorectal carcinomas (n = 10), both chlorhexidine-cetrimide and povidone-iodine were rapidly lethal at a wide range of concentrations (5-100%). Mercuric perchloride (0.2%) was similarly effective, but up to 20% of tumour cells remained viable after exposure to noxythiolin and nearly 30% with water alone. Chlorhexidine-cetrimide and povidone-iodine are the agents of choice to kill malignant cells exfoliated into the colorectal lumen.
The root endodermis: A hub of developmental signals and nutrient flow (2011)

The root endodermis is the cylindrical boundary that separates the inner vascular tissue from the outer cortex and functions as an apoplasmic barrier for selective nutrient uptake. Recent developmental and cell biological studies have started to reveal the mechanisms by which this single cell layer serves as a key regulatory module of root growth, tissue patterning and nutrient flow, which in concert support the plant's ability to survive in a terrestrial habitat. This review provides an overview of the key factors that contribute to the functioning of the root endodermis and discusses how this single cell layer dictates root growth and tissue patterning.
Esters of 6‐(4′‐fluorobenzylamino)‐β‐ carboline‐3‐carboxylic acid as potential benzodiazepine imaging agents for P.E.T. (1995)

Abstract As potential P.E.T. imaging agents for the benzodiazepine receptor, two fluorine‐ 18 labeled analogues of the β‐carbolines were prepared via N‐ alkylation of the corresponding desbenzyl amine precursors with [ 18 F]fluorobenzyl iodide.
Cohesin Cleavage by Separase Required for Anaphase and Cytokinesis in Human Cells (2001)

Cell division depends on the separation of sister chromatids in anaphase. In yeast, sister separation is initiated by cleavage of cohesin by the protease separase. In vertebrates, most cohesin is removed from chromosome arms by a cleavage-independent mechanism. Only residual amounts of cohesin are cleaved at the onset of anaphase, coinciding with its disappearance from centromeres. We have identified two separase cleavage sites in the human cohesin subunit SCC1 and have conditionally expressed noncleavable SCC1 mutants in human cells. Our results indicate that cohesin cleavage by separase is essential for sister chromatid separation and for the completion of cytokinesis.
Exploring the Limits of Energy Efficiency in Office Buildings (2011)

This paper explores the limiting energy efficiency for the energy uses in a particular office building. This limit might be viewed as the “Carnot efficiency” for the entire building. It assumes that all energy‐consuming services in the building are provided at the minimum energy value that does not violate physical law. Rigorous physical limits such as the Carnot efficiency are used where applicable; in other cases, a plausible approximation has been adopted. Based on the assumptions made, it would be possible to provide all of the energy‐based services currently provided in the building using approximately 0.2 kWh/(ft2−yr). This limiting value is less than 1% of the energy used by a typical office building in the United States. Examination of expected advances in individual technologies suggests that it may be possible to construct a building that uses approximately 0.8 kWh/(ft2−yr) within the next decade.
Table S3 from Comparative Tumor Microenvironment Analysis of Primary and Recurrent Ovarian Granulosa Cell Tumors (2023)

&lt;p&gt;Differentially Expressed Genes&lt;/p&gt;
3D static elastography at the micrometer scale using Full Field OCT (2013)

Full-Field OCT (FF-OCT) is able to image biological tissues in 3D with micrometer resolution. In this study we add elastographic contrast to the FF-OCT modality. By combining FF-OCT with elastography, we create a virtual palpation map at the micrometer scale. We present here a proof of concept on multi-layer phantoms and preliminary results on ex vivo biological samples such as porcine cornea, human breast tissues and rat heart. The 3D digital volume correlation that is used in connection with the 3D stack of images allows to access to the full 3D strain tensor and to reveal stiffness anisotropy.
Simplified Equations for Planning Directional and Horizontal Wells (1990)

ABSTRACT Directional drilling techniques have been used for many years to reach subsurface objectives that have had inaccessible surface locations. Economic considerations and increased environmental concerns have increased the number of directional wells drilled in recent years. Directional drilling techniques have also been applied to horizontal drilling with interest in this area increasing greatly over the last several years. In the past, there have been two major methods utilized in planning the directional well. These methods are the use of buildup or composite buildup charts and the use of several directional well planning equations, each method depending on the particular wellbore geometry desired. The use of buildup charts is a tedious process that often yields inaccurate results since it requires using preplotted graphs that require interpretation and interpolation. The equation approach is often confusing to use due to the similarity of the various equations with the selection of the proper equation dependent on the desired wellbore geometry. This paper presents the derivation of a single equation for planning the trajectory of any directional well and a similar equation for any horizontal well. Several examples are used to demonstrate the application of the equations to various wellbore geometries.
Neuromorphic computation with spiking memristors: habituation, experimental instantiation of logic gates and a novel sequence-sensitive perceptron model (2018)

Memristors have been compared to neurons and synapses, suggesting they would be good for neuromorphic computing. A change in voltage across a memristor causes a current spike which imparts a short-term memory to a memristor, allowing for through-time computation, which can do arithmetical operations and sequential logic, or model short-time habituation to a stimulus. Using simple physical rules, simple logic gates such as XOR, and novel, more complex, gates such as the arithmetic full adder (AFA) can be instantiated in sol-gel TiO2 plastic memristors. The adder makes use of the memristor's short-term memory to add together three binary values and outputs the sum, the carry digit and even the order they were input in, allowing for logically (but not physically reversible) computation. Only a single memristor is required to instantiate each gate, as additional input/output ports can be replaced with extra time-steps allowing a single memristor to do a hitherto unexpectedly large amount of computation, which may mitigate the memristor's slow operation speed and may relate to how neurons do a similarly large computation with slow operation speeds. These logic gates can be understood by modelling the memristors as a novel type of perceptron: one which is sensitive to input order. The memristor's short-term memory can change the input weights applied to later inputs, and thus the memristor gates cannot be accurately described by a single perceptron, requiring either a network of time-invariant perceptrons, or a sequence-sensitive self-reprogrammable perceptron. Thus, the AFA is best described as a sequence-sensitive perceptron that sorts binary inputs into classes corresponding to the arithmetical sum of the inputs. Co-development of memristor hardware alongside software (sequence-sensitive perceptron) models in trained neural networks would allow the porting of modern deep-neural networks architecture to low-power hardware neural net chips.