gebhart/patrepeval huggingface dataset:
Flow cytometric estimation of ‘labile iron pool’ in human white blood cells reveals a positive association with ageing (2008)

A small part of cellular iron, usually called 'labile iron pool' (LIP), is not securely stored and has the potential to catalyse the formation of highly reactive oxygen species. The present work estimated LIP levels in human white cells by using the analytical power of flow cytometry. The method relies essentially on already established principles but has the added value of monitoring LIP in different subpopulations of human blood cells concurrently in a single sample. Examination of 41 apparently healthy individuals revealed a positive correlation between LIP levels and the age of the donors (r=0.656, 0.572 and 0.702 for granulocytes, lymphocytes and monocytes, respectively, p<0.0001), indicating that cells of older individuals are prone to oxidations in conditions of oxidative stress. It is suggested that LIP estimation may represent a valuable tool in examinations searching for links between iron and a variety of oxidative stress-related pathological conditions.
Targeting the Fn14-Rac1 signaling pathway in invasive glioma cells (2008)

1995 Genetic alterations in malignant gliomas affect cell proliferation and cell cycle control, and are currently the targets of most chemotherapeutic agents. However, the efficacy of treating advanced glial tumors with adjuvant therapies remains largely unsuccessful due to the inability to effectively target invading cells. We have been investigating whether the multifunctional cytokine tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor fibroblast growth factor-inducible 14 (Fn14) regulate glioma cell invasive activity. In a previous report, we demonstrated that Fn14 expression was elevated in glioblastoma multiforme (GBM) specimens and also up-regulated in migrating glioma cells in vitro and invading cells in vivo. Moreover, Fn14-induced glioma invasion is dependent on the small GTPase Rac1. Rac1 is a ubiquitous signaling protein operating in many normal tissues; consequently, therapeutic targeting of this protein would likely have toxic effects on normal cells. It is possible that targeting key regulators of Rac1 may be a more effective and specific therapy toward invading glioma cells. In this study, we found that Ect2, a guanine nucleotide exchange factor (GEF) for Rho family GTPases, including Rac1 and Cdc42, is overexpressed in GBM, and that overexpression of Ect2 correlates directly with tumor grade and inversely with patient survival. Our data shows that Ect2 regulates Rac1 activation downstream of Fn14. Depletion of Ect2 by siRNA duplexes abrogates Fn14-induced Rac1 activation and subsequently glioma cell migration. We also found that TWEAK stimulates the activation of Cdc42 and that this is mediated by Ect2. Interestingly, depletion of Cdc42 expression impairs TWEAK-induced Rac1 activation and also results in a significant reduction of glioma cell migration in vitro. This suggests that Cdc42 is, in part, important for Rac1 activation downstream of the TWEAK-Fn14 signaling pathway and argues for the presence of other Rac-GEF(s) being involved in the Fn14-Rac1 signaling axis. Thus, therapy designed to interfere with the function of specific Fn14 signaling elements is likely to target invasive glioblastoma cells.
Reduction of coding artifacts in transform image coding (1993)

The problem of image decompression is cast as an ill-posed inverse problem, and a stochastic regularization technique is used to form a well-posed reconstruction algorithm. A statistical model for the image which incorporates the convex Huber minimax function is proposed. The use of the Huber minimax function rho T(.) helps to maintain the discontinuities from the original image which produces high-resolution edge boundaries. Since rho T(.) is convex, the resulting multidimensional minimization problem is a constrained convex optimization problem. The maximum a posteriori (MAP) estimation technique that is proposed results in the constrained optimization of a convex functional. The proposed image decompression algorithm produces reconstructed images which greatly reduced the noticeable artifacts which exist using standard techniques.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Glucose Uptake and Triacylglycerol Synthesis Are Increased in Barth Syndrome Lymphoblasts (2017)

Barth syndrome (BTHS) is an X-linked genetic disease resulting in loss of cardiolipin (Ptd<sub>2</sub>Gro). Patients may be predisposed to hypoglycemia and exhibit increases in whole-body glucose disposal rates and a higher fat mass percentage. We examined the reasons for this in BTHS lymphoblasts. BTHS lymphoblasts exhibited a 60% increase (p < 0.004) in 2-[1,2-<sup>3</sup>H(N)]deoxy-D-glucose uptake, a 40% increase (p < 0.01) in glucose transporter-3 protein expression, an increase in phosphorylated-adenosine monophosphate kinase (AMPK) and a 58% increase (p < 0.001) in the phosphorylated-AMPK/AMPK ratio compared to controls. In addition, BTHS lymphoblasts exhibited a 90% (p < 0.001) increase in D-[U-<sup>14</sup>C]glucose incorporated into 1,2,3-triacyl-sn-glycerol (TAG) and a 29% increase (p < 0.025) in 1,2-diacyl-sn-glycerol acyltransferase-2 activity compared to controls. Thus, BTHS lymphoblasts exhibit increased glucose transport and increased glucose utilization for TAG synthesis. These results may, in part, explain why BTHS patients exhibit an increase in whole-body glucose disposal rates, may be predisposed to hypoglycemia and exhibit a higher fat mass percentage.
Coherent Pulse Propagation and the Dynamics of Rydberg Wave Packets (1997)

The pulse reshaping of femtosecond laser pulses tuned to Rydberg transitions of strontium vapor is observed experimentally. We show theoretically that their shape closely reflects the dynamics of Rydberg wave packets induced by the pulses. The decay and compression of Rydberg wave packets excited by both Fourier limited and chirped fs pulses is presented.
A "Weyco" Experience (1980)

Weyco" ExperienceWeyerhaeuser nursery in Magnolia, Ark.
LUBRICATED URETHRAL CATHETERS WITH LIDOCAINE VERSUS GENTAMYCIN FOR CLEAN INTERMITTENT CATHETERIZATION (2002)

Introduction: Different methods for urinary tract infection prophylaxis have been proposed for patients who undergo intermittent catheterization, such as the lubrication of urethral catheters with 0.1% gentamycin cream. This study compared the lubrication of urethral catheters with 0.1% gentamycin cream and 2% lidocaine jelly in relation to the quantitative results of the urine culture and incidence of symptomatic urinary tract infection and nonsymptomatic bacteriuria in patients who undergo clean intermittent catheterization. Material and Methods: This randomized and prospective study was conducted in a General School Hospital from May/1999 to August/2000. Twenty patients, divided in groups A and B, were studied. Group A patients were directed to lubricate the urethral catheter with 0.1% gentamycin cream, and group B with 2% lidocaine jelly. All of them were advised to discard the catheter after use. Urine cultures and urine analysis were carried out every three weeks, for four months, in a total of 5 samples. The presence or absence of bacteria or fungus, the number of colonies and the isolated types, and the leukocyturia were evaluated. Results: No significant differences in the presence of significant bacteriuria, symptomatic urinary tract infection and nonsymptomatic bacteriuria were found between the two groups. Escherichia coli was the most common isolated bacteria in both groups. There was no growth of fungi. Conclusion: The results of this study showed that the lubrication of urethral catheters with 0.1% gentamycin cream is not an effective alternative to reduce significant bacteriuria and prevent urinary infection in patients who undergo clean intermittent catheterization.
Microbial conversion of steffimycin and steffimycin B to 10-dihydrosteffimycin and 10-dihydrosteffimycin B. (1980)

It has been shown that steffimycin (1) and steffmycin B (2) are reduced at the C-10 carbonyl by Actinoplanes utahensis, UC-5885 and Chaetomium sp., UC-4634, respectively. Using cell-free extracts of the latter organism, the optimum conversion time, pH, and enzyme concentration have been determined for the conversion of 2 to 4. The biochemical conversion of 2 has been found to be TPNH linked.
Functionalized Fluorinated Hyperbranched Polymers for Optical Waveguide Applications (2001)

Fluorinated dendritic or hyperbranched polymers are demonstrated for the first time to be potentially useful for optical waveguide applications, for example in telecommunications. The required materials properties include the control of the refractive index over a wide range and UV-crosslinking for ease of processing and stable long-term mechanical properties. The authors report the synthesis of suitable functionalized fluorinated hyperbranched polymers and how the above requirements can be met by functionalization at the periphery of the polymers.
Smartirrigation Apps: Urban Turf (2013)

We developed an app called Smartirrigation Turf to provide an easy-to-use mobile tool that delivers information to improve irrigation scheduling for urban turf. Using the app instead of a set time-based schedule for irrigation, homeowners and others can provide irrigation amounts to turf that more closely match water needs. This version of the app is applicable in Florida and Georgia and is available to download in the Apple App Store and Google Play Store. This 5-page fact sheet was written by K. W. Migliaccio, J. H. Debastiani Andreis, C. Fraisse, K. T. Morgan, and G. Vellidis, and published by the UF Department of Agricultural and Biological Engineering, October 2013.&#x0D; http://edis.ifas.ufl.edu/ae499
NON-INTRUSIVE TEMPERATURE MEASUREMENT OF PROPELLANT FLAMES AND ROCKET EXHAUSTS ANALYZING BAND PROFILES OF DIATOMIC MOLECULES (1994)

Temperature is the dominating parameter of combustion processes. To achieve realistic results, non-intrusive methods must be applied in measuring flame temperatures. This can be realized by quantitative analysis of the emitted radiation. One well-known technique to determine intensity distribution is emission spectroscopy. Typically, the flame spectra in the ultraviolet (UV, < 350 nm) and visible (VIS, < 750 nm) are governed by band profiles of diatomic molecules. To obtain information about the temperature from their intensity distribution, the experimental values are compared to corresponding calculated spectra. Therefore different transitions of the most important diatomic molecules occurring in flames, like OH, NH, CN, CH, C2, CuH, MgO and AlO, have been calculated and intensity distributions modeled. In most cases, the calculated spectra showed only a small deviation from the observed experimental intensity distributions. To determine the combustion temperatures of different processes, recorded experimental spectra were compared to calculated data by a least squares fit routine with the parameter temperature and halfwidth of the line profile. The method was applied to solid propellant flames and rocket exhausts. The temperatures determined showed realistic values compared to those obtained in other studies. The possibility of using different radicals in the same flame allows a clearer discussion of the values achieved.
High Performance Multiwall Carbon Nanotube–Insulator–Metal Tunnel Diode Arrays for Optical Rectification (2018)

Abstract This work reports important fundamental advancements in multiwall carbon nanotube (MWCNT) rectenna devices by creating and optimizing new diode structures to allow optical rectification with air‐stable devices. The incorporation of double‐insulator layer tunnel diodes, fabricated for the first time on MWCNT arrays, enables the use of air‐stable top metals (Al and Ag) with excellent asymmetry for rectification applications. Asymmetry is increased by as much as 10 times, demonstrating the effectiveness of incorporating multiple dielectric layers to control electron tunneling in MWCNT diode structures. MWCNT tip opening also reduces device resistance up to 75% due to an increase in diode contact area to MWCNT inner walls. This effect is consistent for different oxide materials and thicknesses. A number of insulator layers, including Al 2 O 3 , HfO 2 , TiO 2 , ZnO, and ZrO 2 , in both single‐ and then double‐insulator configurations are tested. Resistance increases exponentially with insulator thickness and decreases with electron affinity. These results are used to characterize double‐insulator diode performance. Finally, for the most asymmetric device structure, Al 2 O 3 ‐HfO 2 (4/4 nm), optical rectification at a frequency of 470 THz (638 nm) is demonstrated. These results open the door for designing efficient MWCNT rectenna devices with more material flexibility, including air‐stable, transparent, and conductive top electrode materials.
EIF2AK2 Missense Variants Associated with Early Onset Generalized Dystonia (2020)

We identified EIF2AK2 variants implicated in early onset generalized dystonia, which can be dominantly or recessively inherited, or occur de novo. Our findings provide direct evidence for a key role of a dysfunctional eIF2α pathway in the pathogenesis of dystonia. ANN NEUROL 2021;89:485-497.
Quality Analysis Approaches for Cloud Services - Towards a Framework along the Customer's Activity Cycle. (2014)

This literature review synthesizes the existing research on quality analysis approaches for cloud services by investigating 25 relevant sources in detail. Further, it integrates thee approaches along the dimensions of service quality and along the customer?s activity cycle, being the pre-purchase, pur-chase and post-purchase phase. This work reveals multiple quality analysis approaches which focus either on specific quality aspects or on a specific step in the activity cycle. Only one ap-proach could be identified which actively supports customers throughout all phases of their quality analysis work and fully covers the dimensions of service quality. However, as approaches for specific areas are far more detailed and tai-lored to challenges in the cloud service ecosystem, we call for further research towards integrating them along the customer?s activity cycle. Further, empirical studies investigating customers? requirements towards guidance on quality analysis could not be found in the literature.
Assessment of Biologic Aggressiveness of Prostate Cancer: Correlation of MR Signal Intensity with Gleason Grade after Radical Prostatectomy (2007)

Higher Gleason grades were associated with lower tumor-muscle SI ratios on T2-weighted MR images. SI evaluation on T2-weighted MR images may facilitate noninvasive assessment of prostate cancer aggressiveness.
Genotype–environment interaction and the ontogeny of diet-induced phenotypic plasticity in size and shape of Melanoplus femurrubrum (Orthoptera: Acrididae) (1999)

Abstract The developmental origin of phenotypic plasticity in morphological shape can be attributed to environment-specific changes in growth of overall body size, localized growth of a morphological structure or a combination of both. I monitored morphological development in the first four nymphal instars of grasshoppers (Melanoplus femurrubrum) raised on two different plant diets to determine the ontogenetic origins of diet-induced phenotypic plasticity and to quantify genetic variation for phenotypic plasticity. I measured diet-induced phenotypic plasticity in body size (tibia length), head size (articular width and mandible depth) and head shape (residual articular width and residual mandible depth) for grasshoppers from 37 full-sib families raised on either a hard plant diet (Lolium perenne) or a soft plant diet (Trifolium repens). By the second to third nymphal instar, grasshoppers raised on a hard plant diet had significantly smaller mean tibia length and greater mean residual articular width (distance between mandibles adjusted for body size) compared with full-sibs raised on a soft plant diet. However, there was no significant phenotypic plasticity in mean unadjusted articular width and mandible depth, and in mean residual mandible depth. At the population level, development of diet-induced phenotypic plasticity in grasshopper head shape is mediated by plastic changes in allocation to tissue growth that maintain growth of head size on hard, low-nutrient diets while reducing growth of body size. Within the population, there was substantial variation in the plasticity of growth trajectories since different full-sib families developed phenotypic plasticity of residual articular width through different combinations of head and body size growth. Genetic variation for diet-induced phenotypic plasticity of residual articular width, residual mandible depth and tibia length, as estimated by genotype–environment interaction, exhibited significant fluctuation through ontogeny (repeated measures MANOVA, family × plant × instar, P &amp;lt; 0.01). For example, there was significant genetic variation for phenotypic plasticity of residual articular width in the third nymphal instar, but not earlier or later in ontogeny. The observed patterns of genetic variation are discussed with reference to short-term constraints and the evolution of phenotypic plasticity.
OFFSITE OIL FIELD WASTE DISPOSAL VARIES ACROSS U.S. (1997)

Cost and availability of offsite commercial oil field waste disposal vary considerably across the U.S. and substantially depend on such factors as the disposal method, the state in which the disposal company is located, and the degree of competition in the area. The two major U.S. offsite disposal trends are as follows: (1) Nine oil and gas-producing states have numerous commercial disposal companies that handle oil field wastes exclusively. These companies use the same disposal methods as on site disposal. These states are Arkansas, California, Louisiana, New Mexico, Oklahoma, Pennsylvania, Texas, Utah, and Wyoming. (2) Twenty-two other oil and gas-producing states have few or no disposal companies dedicated to oil and gas industry waste.
ChemInform Abstract: Synthesis of N‐Boc‐3‐Azabicyclo(3.3.0)octan‐7‐one via Reductive Pauson‐ Khand Cyclization and Subsequent Conversion to a Novel Diazatricyclic Ring System. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Effects of volatile coatings on the laser-induced incandescence of black carbon. (2012)

Abstract not provided.
Heat transfer studies using Ln3+ based nanothermometers (2014)

Trabajo presentado al: "Eurotherm 103: Nanoscale and Microscale Heat Transfer IV" celebrado en Lyon (Francia) del 15 al 17 de octubre de 2014.
Platinum Nickel Nanowires as Methanol Oxidation Electrocatalysts (2015)

We investigated platinum(Pt) nickel (Ni) nanowires (PtNiNWs) as methanol oxidation reaction (MOR) catalysts in rotating disk electrode (RDE) half-cells under acidic conditions. Pt-ruthenium (Ru) nanoparticles have long been the state of the art MOR catalyst for direct methanol fuel cells (DMFCs) where Ru provides oxophilic sites, lowering the potential for carbon monoxide oxidation and the MOR onset. Ru, however, is a precious metal that has long term durability concerns. Ni/Ni oxide species offer a potential to replace Ru in MOR electrocatalysis. PtNiNWs were investigated for MOR and oxygen annealing was investigated as a route to improve catalyst performance (mass activity 65% greater) and stability to potential cycling. Our results presented show that PtNiNWs offer significant promise in the area, but also result in Ni ion leaching that is a concern requiring further evaluation in fuel cells.
Native ISS-SystemC integration for the co-simulation of multi-processor SoC (2004)

In a system-level design flow, the transition from a high-level description entry implies the refinement from an untimed, unpartitioned description to a real architecture where applications are executed on a programmable device and interact with ad-hoc hardware components. Simulation of such architectures requires the capability of efficient co-simulation of a model of hardware with a model of the processor. This paper presents two co-simulation methodologies, based on SystemC as hardware modeling language and on an instruction set simulator (ISS) as a model of the processor. The first one works at the SystemC kernel level and exploits potentialities of the GNU suite, whereas the second uses features offered by the operating system running on the ISS. The two methodologies improve co-simulation performance with respect to state-of the art methods, and provide different trade-offs between the simplicity of the programming model, the modeling power, and co-simulation performance.
Detection of interictal epileptiform discharges: A comparison of on-scalp MEG and conventional MEG measurements (2020)

On-scalp MEG has the potential of improving non-invasive epilepsy evaluation.
Encapsulation Methods for Transport of Layer 2 Frames over MPLS Networks (2007)

This document describes methods for encapsulating the Protocol Data
Units (PDUs) of layer 2 protocols such as Frame Relay, ATM, or
Ethernet for transport across an MPLS or IP network.
Loss of Smarc Proteins Impairs Cerebellar Development (2014)

SMARCA4 (BRG1) and SMARCB1 (INI1) are tumor suppressor genes that are crucially involved in the formation of malignant rhabdoid tumors, such as atypical teratoid/rhabdoid tumor (AT/RT). AT/RTs typically affect infants and occur at various sites of the CNS with a particular frequency in the cerebellum. Here, granule neurons and their progenitors represent the most abundant cell type and are known to give rise to a subset of medulloblastoma, a histologically similar embryonal brain tumor. To test how Smarc proteins influence the development of granule neurons and whether this population may serve as cellular origin for AT/RTs, we specifically deleted Smarca4 and Smarcb1 in cerebellar granule cell precursors. Respective mutant mice displayed severe ataxia and motor coordination deficits, but did not develop any tumors. In fact, they suffered from a severely hypoplastic cerebellum due to a significant inhibition of granule neuron precursor proliferation. Molecularly, this was accompanied by an enhanced activity of Wnt/β-catenin signaling that, by itself, is known to cause a nearly identical phenotype. We further used an hGFAP-cre allele, which deleted Smarcb1 much earlier and in a wider neural precursor population, but we still did not detect any tumor formation in the CNS. In summary, our results emphasize cell-type-dependent roles of Smarc proteins and argue against cerebellar granule cells and other progeny of hGFAP-positive neural precursors as the cellular origin for AT/RTs.