gebhart/patrepeval huggingface dataset:
Midline Shift Due to Acute Intracranial Hemorrhage in the Surgical ICU: Bedside or OR for Decompression? (2022)

Article| April 2022 Midline Shift Due to Acute Intracranial Hemorrhage in the Surgical ICU: Bedside or OR for Decompression? Monica Lupei, MD; Monica Lupei, MD Search for other works by this author on: This Site PubMed Google Scholar Brian Tolly, MD; Brian Tolly, MD Search for other works by this author on: This Site PubMed Google Scholar David Darrow, MD, MPH; David Darrow, MD, MPH Search for other works by this author on: This Site PubMed Google Scholar Andrew Grande, MD; Andrew Grande, MD Search for other works by this author on: This Site PubMed Google Scholar Daniel Guillaume, MD, MS; Daniel Guillaume, MD, MS Search for other works by this author on: This Site PubMed Google Scholar Kumar Belani, MBBS, MS; Kumar Belani, MBBS, MS Search for other works by this author on: This Site PubMed Google Scholar Tjorvi E. Perry, MD, MMSc Tjorvi E. Perry, MD, MMSc Search for other works by this author on: This Site PubMed Google Scholar ASA Monitor April 2022, Vol. 86, 34–35. https://doi.org/10.1097/01.ASM.0000827000.05952.2d Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share MailTo Twitter LinkedIn Cite Icon Cite Get Permissions Search Site Citation Monica Lupei, Brian Tolly, David Darrow, Andrew Grande, Daniel Guillaume, Kumar Belani, Tjorvi E. Perry; Midline Shift Due to Acute Intracranial Hemorrhage in the Surgical ICU: Bedside or OR for Decompression?. ASA Monitor 2022; 86:34–35 doi: https://doi.org/10.1097/01.ASM.0000827000.05952.2d Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll PublicationsASA Monitor Search Advanced Search Topics: brain herniation, decompression, external, decompressive incision, intensive care unit, intracranial hemorrhages, surgical procedures, operative As anesthesiologists, intensivists, and surgeons in a quaternary academic medical center, we often find ourselves in situations where life-altering decisions need to be made in a complex environment with incomplete and rapidly changing information. In our estimation, this has never been truer than with the patient being discussed herein. Patients on anticoagulants are at greater risk of acute intracranial bleeding, a neurosurgical emergency that benefits from immediate attention. While relatively uncommon, a patient who presents with an acute or evolving intracranial hemorrhage is traditionally transferred to the closest OR for immediate evacuation, regardless of whether the patient is at home, on the medical ward, or in the ICU. In this article, we highlight a recent debate on whether a 35-year-old female with peripartum cardiomyopathy, anticoagulated for right and left ventricular assist devices (VAD) who presented with acute intracranial bleeding while in the ICU, should have been operated on at the... You do not currently have access to this content.
Imbalance Learning Using Neural Networks for Seizure Detection (2018)

Around 1% of world's population suffer from epileptic seizures which can lead to injuries and even unexpected death. Making use of EEG signals, which are proven to be the best indicators of seizures, we aim to build an Artificial Neural Networks to classify seizure and non-seizure events. However, the limited availability of seizure events in the EEG data makes it difficult for the automatic classifiers in general to accurately classify seizure events. To improve this, we propose an imbalance learning approach to improve accuracy of highly imbalanced seizure dataset. Since each patient provides a different response to the seizure, we personalize the classification models in terms of training data and model parameters. The proposed imbalance learning method provides an average F-measure accuracy above 86% for Physionet MIT dataset.
<title>Operational level decision aids with LG-based tools</title> (2002)

The LG approach permits a game representation of the Engagement Theater in two modes, called the planning mode and the execution mode. The planning mode assumes that the computations are to be performed well before the actual engagement and thus a sophisticated (but slower) planning component of the LG hypergame is to be activated. On the planning stage, the emphasis is on the following. 1) distributing the battlefield resources to optimize some battlefield related criteria. Important optimization criteria are battlefield related, ones such as probabilities to achieve desired ends and survivability of the friendly forces; 2) developing of preliminary strategies for the commander to achieve certain desired end; 3) playing several what if situations to develop alternative strategies. Whereas the COA options for the resource distribution game could influence the COA options for selection of the preliminary and alternative strategies, the strategies are used to validate the effectiveness of the resource distribution, thus creating a feedback loop tying together the resources and battlefield actions. On the execution stage, the emphasis is on protecting the commander from possible errors caused by the information blizzard. The commander could have so many things on his/her mind that some negative consequences of a COA being decided upon may be overlooked. A faster execution version of the LG-based tool is intended to catch the undesired consequence and warn the commander.
Human Als3p Antibodies are Surrogate Markers of NDV-3A Vaccine Efficacy Against Recurrent Vulvovaginal Candidiasis (2018)

Abstract A Phase 1b/2a clinical trial of NDV-3A vaccine containing a Candida albicans recombinant Als3 protein protected women &lt;40 years old from recurrent vulvovaginal candidiasis (RVVC). We investigated the potential use of anti-Als3p sera as surrogate marker of NDV-3A efficacy. Pre- and post-vaccination sera from subjects who experienced recurrence of VVC (R) versus those who were recurrence-free (non-recurrent, NR) were evaluated. Anti-Als3p antisera obtained were evaluated for; 1) titer and subclass profile; 2) their ability to influence C. albicans virulence traits including hyphal elongation, adherence to plastic, invasion of vaginal epithelial cells, biofilm formation on plastic and catheter material, and susceptibility to neutrophil killing in vitro. Serum IgG titers in NR patients were consistently higher than in R patients, particularly for anti-Als3 subclass IgG2. Sera from vaccinated NR patients reduced hyphal elongation, adhesion to plastic, invasion of vaginal epithelial cells and biofilm formation significantly more than pre-immune sera, or sera from R- or placebo-group subjects. Pre-adsorption of sera with C. albicans germ tubes eliminated these effects, while heat inactivation did not. Finally, sera from NR subjects enhanced neutrophil-mediated killing of C. albicans relative to pre-immune sera or sera from R patients. Our results suggest that higher Als3p antibody titers are associated with protection from RVVC, attenuate C. albicans virulence and augment immune clearance of the fungus in vitro. Thus, Als3p serum IgG antibodies are likely useful markers of efficacy in RVVC patients vaccinated with NDV-3A. Abbreviations Als3p Agglutinin-like sequence 53 3 protein AUC area under the curve CFU colony forming unit ConA Concanavalin A ELISA enzyme-linked immunosorbent assay Hyr1p hyphal regulating protein 1 IRB institutional review board OPK opsonophagocytic killing NR non-recurrent NDV-3 recombinant His-tagged N-terminus of Als3p R formulated with alum NDV-3A recombinant N-terminus of Als3p R formulated with alum recurrent RVVC recurrent vulvovaginal candidiasis ROC Receiver-operating characteristic Sap2 secreted aspartyl proteinase 2 SE silicone elastomer VVC vulvovaginal candidiasis YNB yeast nitrogen base YPD yeast peptone dextrose
REAL-TIME MONITORING OF UAV PHOTO SHOOTING FOR 3D RECONSTRUCTION (2022)

図面等が残存しない既設インフラに対する維持管理において，写真測量に基づくSfM（Structure from Motion）による3次元データ化を導入するケースが増えている．足場を選ばないUAV（Unmanned Aerial Vehicle）による空撮は効率的であるが，立体構造物の測量撮影には属人的技能が要求されるだけでなく，SfMに多大な計算時間を要する上に，事前には3次元データ化の成否が分からない．本研究ではSLAM（Simultaneous Localization and Mapping）により，UAVの撮影視点をモニターし，3次元データ化に対する適否を実時間で判断するシステムを提案する．被写体に対する相対移動速度とSfMの成否との因果に基づいた指標を導出し，実験によりその有効性を確認した．
Recent developments in carbapenems (2002)

Carbapenems are beta-lactam antibiotics characterised by the presence of a beta-lactam ring with a carbon instead of sulfone in the 4-position of the thyazolidinic moiety. The first carbapenem to be utilised in therapy was imipenem, the N-formimidoyl derivative of thienamycin. Imipenem is coadministered with cilastatin, an inhibitor of human renal dehydropeptidase I, as imipenem is hydrolysed by this enzyme. Meropenem was the first carbapenem with a 1-beta-methyl group and 2-thio pyrrolidinyl moiety, which renders this antibiotic stable to renal dehydropeptidase I. Other carbapenems for parenteral administration later discovered include biapenem, panipenem, ertapenem, lenapenem, E-1010, S-4661 and BMS-181139. Carbapenems which are orally administered include sanfetrinem, DZ-2640, CS-834 and GV-129606. Carbapenems have an ultra-broad spectrum of antibacterial activity and stability to almost all clinically relevant beta-lactamases. This differentiates them from all other currently available classes of beta-lactam antibiotics. However, Class B beta-lactamases, along with some rare Class A and D enzymes, are able to hydrolyse these antibiotics. Although Class B enzymes are generally chromosomally-encoded (isolated from Stenotrophomonas maltophilia, Aeromonas spp., Bacillus cereus, Bacteroides fragilis, Flavobacterium spp. and Legionella gormanii), plasmid-metallo-beta-lactamases now are appearing in B. fragilis, Pseudomonas aeruginosa, Acinetobacter baumannii and members of Enterobacteriaceae such as Serratia marcescens and Klebsiella pneumoniae. The number of these enzymes compared to the number of other beta-lactamase types is still low, however, it is likely that they will spread due to the increased selective pressure of carbapenem use. The very broad spectrum of antimicrobial activity associated with a good clinical efficacy and a favourable safety profile makes the carbapenems valuable as 'first-line' antibiotics in initial empirical therapy for the treatment of severe infections.
Robust deep learning features for face recognition under mismatched conditions (2018)

In this paper, we addressed the problem of face recognition under mismatched conditions. In the proposed system, for face representation, we leveraged the state-of-the-art deep learning models trained on the VGGFace2 dataset. More specifically, we used pretrained convolutional neural network models to extract 2048 dimensional feature vectors from face images of International Challenge on Biometric Recognition in the Wild dataset, shortly, ICB-RW 2016. In this challenge, the gallery images were collected under controlled, indoor studio settings, whereas probe images were acquired from outdoor surveillance cameras. For classification, we trained a nearest neighbor classifier using correlation as the distance metric. Experiments on the ICB-RW 2016 dataset have shown that the employed deep learning models that were trained on the VGGFace2 dataset provides superior performance. Even using a single model, compared to the ICB-RW 2016 winner system, around 15% absolute increase in Rank-1 correct classification rate has been achieved. Combining individual models at feature level has improved the performance further. The ensemble of four models achieved 91.8% Rank-1, 98.0% Rank-5 identification rate, and 0.997 Area Under the Curve of Cumulative Match Score on the probe set. The proposed method significantly outperforms the Rank-1, Rank-5 identification rates, and Area Under the Curve of Cumulative Match Score of the best approach at the ICB-RW 2016 challenge, which were 69.8%, 85.3%, and 0.954, respectively.
Soliton compression (˜ 1.2 ps) of gain-switched DFB laser using an erbium-doped fiber amplifier (2005)

Optimum conditions were studied systematically for a system consisting of a gain-switched DHB laser, an EDFA, and a soliton fiber. Compressed pulses around 1.2ps with suppressed pedestal and reasonable pulse energy of 40pJ were obtained.
Improving the efficiency of deconvolution algorithms for sound source localization (2015)

The localization of sound sources with delay-and-sum (DAS) beamforming is limited by a poor spatial resolution-particularly at low frequencies. Various methods based on deconvolution are examined to improve the resolution of the beamforming map, which can be modeled by a convolution of the unknown acoustic source distribution and the beamformer's response to a point source, i.e., point-spread function. A significant limitation of deconvolution is, however, an additional computational effort compared to beamforming. In this paper, computationally efficient deconvolution algorithms are examined with computer simulations and experimental data. Specifically, the deconvolution problem is solved with a fast gradient projection method called Fast Iterative Shrikage-Thresholding Algorithm (FISTA), and compared with a Fourier-based non-negative least squares algorithm. The results indicate that FISTA tends to provide an improved spatial resolution and is up to 30% faster and more robust to noise. In the spirit of reproducible research, the source code is available online.
Influence of Mechanical Surface Treatments on the Fatigue Performance of the Gamma TiAl Alloy Ti-45Al-9Nb-0.2C (2007)

The effect of shot peening and roller burnishing on the fatigue performance of the γ(TiAl) alloy Ti-45Al-9Nb-0.2C was investigated over a wide range of processing intensities. At optimized conditions shot peening and roller burnishing can markedly improve the fatigue strength at ambient temperatures. For temperatures above 650 °C, the residual compressive stresses induced by shot peening and roller burnishing quickly relax. This indicates that, at elevated temperatures, surface roughness and dislocation strengthening become more important for the fatigue performance of mechanically surface-treated components. Roller burnishing leads to much lower surface roughness than shot peening, resulting in more effective improvement of high temperature fatigue performance. However, surface strengthening by shot peening can also be beneficial for the fatigue performance at elevated temperatures, when the surface roughness is reduced by subsequent polishing.
Gas Turbine Engine Durability Impacts of High Fuel-Air Ratio Combustors—Part I: Potential for Secondary Combustion of Partially Reacted Fuel (2003)

Demand for greater engine efficiency and thrust-to-weight ratio has driven the production of aircraft engines with higher core temperatures and pressures. Such engines operate at higher fuel-air ratios, resulting in the potential for significant heat release through the turbine if species, such as CO and HC, are emitted from the combustor in large quantities. This paper outlines the magnitude and potential for turbine heat release in current and future engines. The analysis suggests that high fuel-air ratio designs may have to consider changes to cooling strategies to accommodate secondary combustion. A characteristic time methodology is developed to evaluate the chemical and fluid mechanical conditions that lead to combustion within the turbine. Local species concentrations partly determine the potential for energy release. An energy release parameter, here defined as a maximum increase in total temperature ΔTt, is used to specify an upper limit on the magnitude of impact. The likelihood of such impacts is set by the convective, mixing, and chemical processes that determine the fate and transport of species through the turbine. Appropriately defined Damko¨hler numbers (Da)—the comparative ratio of a characteristic flow time τflow to a characteristic chemical time τchem—are employed to capture the macroscopic physical features controlling the flow-chemistry interactions that lead to heat release in the turbine.
Data profiling revisited (2014)

Data profiling comprises a broad range of methods to efficiently analyze a given data set. In a typical scenario, which mirrors the capabilities of commercial data profiling tools, tables of a relational database are scanned to derive metadata, such as data types and value patterns, completeness and uniqueness of columns, keys and foreign keys, and occasionally functional dependencies and association rules. Individual research projects have proposed several additional profiling tasks, such as the discovery of inclusion dependencies or conditional functional dependencies. Data profiling deserves a fresh look for two reasons: First, the area itself is neither established nor defined in any principled way, despite significant research activity on individual parts in the past. Second, more and more data beyond the traditional relational databases are being created and beg to be profiled. The article proposes new research directions and challenges, including interactive and incremental profiling and profiling heterogeneous and non-relational data.
Charge Transport Layers Limiting the Efficiency of Perovskite Solar Cells: How To Optimize Conductivity, Doping, and Thickness (2019)

Perovskite solar cells (PSCs) are one of the main research topics of the photovoltaic community; with efficiencies now reaching up to 24%, PSCs are on the way to catching up with classical inorganic solar cells. However, PSCs have not yet reached their full potential. In fact, their efficiency is still limited by nonradiative recombination, mainly via trap-states and by losses due to the poor transport properties of the commonly used transport layers (TLs). Indeed, state-of-the-art TLs (especially if organic) suffer from rather low mobilities, typically within 10-5 and 10-2 cm2 V-1 s-1, when compared to the high mobilities, 1-10 cm2 V-1 s-1, measured for perovskites. This work presents a comprehensive analysis of the effect of the mobility, thickness, and doping density of the transport layers based on combined experimental and modeling results of two sets of devices made of a solution-processed high-performing triple-cation (PCE ≈ 20%). The results are also cross-checked on vacuum-processed MAPbI3 devices. From this analysis, general guidelines on how to optimize a TL are introduced and especially a new and simple formula to easily calculate the amount of doping necessary to counterbalance the low mobility of the TLs.
Human scalp hair as a thermoregulatory adaptation (2023)

Humans are unique among mammals in having a functionally naked body with a hair-covered scalp. Scalp hair is exceptionally variable across populations within <i>Homo sapiens</i>. Neither the function of human scalp hair nor the consequences of variation in its morphology have been studied within an evolutionary framework. A thermoregulatory role for human scalp hair has been previously suggested. Here, we present experimental evidence on the potential evolutionary function of human scalp hair and variation in its morphology. Using a thermal manikin and human hair wigs at different wind speeds in a temperature and humidity-controlled environment, with and without simulated solar radiation, we collected data on the convective, radiative, and evaporative heat fluxes to and from the scalp in relation to properties of a range of hair morphologies, as well as a naked scalp. We find evidence for a significant reduction in solar radiation influx to the scalp in the presence of hair. Maximal evaporative heat loss potential from the scalp is reduced by the presence of hair, but the amount of sweat required on the scalp to balance the incoming solar heat (i.e., zero heat gain) is reduced in the presence of hair. Particularly, we find that hair that is more tightly curled offers increased protection against heat gain from solar radiation.
Acute changes in plasma carnosine, creatine and markers of purine degradation following exercise (2007)

Previous data has shown that exercise can result in the release of myocellular constituents. This study assessed the acute changes in plasma amines and markers of purine degradation following exercise. Following an overnight fast subjects (n = 6, 26±6y; 82.7±21.6kg; 57.1±9.3ml.kg −1. min −1 ) undertook running or cycling, in a randomised order with trials separated by 1 week. Exercise consisted of a 60 min run at 70% peak speed, or 5 repeated Wingate’s (30s cycle sprint, 2min active recovery). Blood samples were drawn pre, and at 0, 5, 30, 360min and 24hrs following exercise. Carnosine was 30% higher following Wingate sprints than running, while taurine was higher following running with the opposite release profile evident following repeated Wingate’s. Markers of purine degradation (uric acid, ammonia) and creatine where significantly elevated following both exercise bouts, but to a higher degree following Wingate’s. Creatine kinase immediately post running exercise was increased. CONCLUSION: Prolonged or intense exercise results in the release of Carnosine and Taurine, which due to their preferential distributions in type I and II muscle fibres may provide unique markers of fibre specific muscle damage.
Influence of facet phases on adiabatic chirp behavior of index-coupled distributed-feedback lasers (2012)

The adiabatic chirp for antireflection/high-reflection DFB laser is mostly dependent on high-reflection facet phase independently of the antireflection quality while very low reflectivity allows chirp predicting from the laser emission spectrum.
The impact of faith on relational thought (2006)

Paper presented at the conf "Faith, freedom and the academy: the idea of the university in the 21st century," Univ of Prince Edward Island, O 1-3 2004.
(Make) Stick and cut loose—Disintegrin metalloproteases in development and disease (2006)

"A disintegrin and metalloprotease" (ADAM) proteases form a still growing family of about 40 type 1 transmembrane proteins. They are defined by a common modular ectodomain architecture that combines cell deadhesion/adhesion and fusion motifs (disintegrin and cysteine-rich domains), with a Zn-protease domain capped by a large prodomain. Their ectodomain thus strikingly resembles snake venom disintegrin proteases, which by combined integrin blocking and extracellular proteolysis, can cause extensive tissue damage after snake bites. A surprisingly large proportion (13 ADAMs) is exclusively expressed in the male gonads, and only a minority can be found throughout all tissues. As predicted by their amino acid sequence, a major proportion of this family has not maintained a functional protease domain, most probably rendering them into pure adhesion and/or fusion proteins. For most ADAMs, the respective key function has remained elusive. Despite their overall conserved ectodomain structure, ADAMs appear to be subdivided into those with a predominant role in direct adhesion (e.g., ADAMs 1, 2, and 3) and those mainly acting as proteases (e.g., ADAMs 10 and 17). Only for a few of them are functions of more than one domain documented (e.g., ADAM9 in cell fusion and proteolysis). Several ADAMs exist in both membrane-resident and secreted isoforms; the functional significance of this dichotomy is in most cases still unclear. Knockout phenotypes have been informative only in a few cases (ADAMs 1, 2, 10, 12, 15, 17, and 19) and are mainly related to their protease function. A common denominator of ADAM-mediated proteolysis is the ectodomain shedding of a broad spectrum of substrates, including paracrine growth factors like epidermal growth factor receptor (EGFR) ligands, cell adhesion molecules like CD44 or cadherins, and the initiation of regulated intramembrane proteolysis (RIP), whereby the transmembrane fragment of the respective substrate is further cleaved by an intramembrane cleaving protease to release an intracellular domain acting as a nuclear transcription regulator. Most ADAMs feature a significant overlap of substrate specificities, explaining why an inactivation of individual ADAMs only rarely causes major phenotypes.