gebhart/patrepeval huggingface dataset:
Découverte et caractérisation pharmacologique de nouveaux antagonistes du récepteur smoothened : les composés mrt (2011)

The Sonic Hedgehog (Shh) signaling pathway is implicated in multiple physiological responses including the control of brain functions. In mammals, the Shh pathway is expressed at the primary cilium and its activation requires the binding of a Shh peptide to the Patched (Ptc) receptor which represses the constitutive activity of Smoothened (Smo), a proposed member of the G-protein-coupled receptor (GPCR) family. Recently, clinical trials for treating medulloblastoma and various solid tumors in human have been conducted with Smo antagonists such as GDC-0449 or LDE-225. Such molecules may have some limitations leading to treatment resistance. In the present work, the development of a pharmacophoric model of Smo antagonists allowed a virtual screening strategy to identify novel Smo inhibitors. The acylthiourea MRT-10 and the acylurea MRT-14 were the two first leads identified. Structure-activity relationship experiments led to the discovery of new series of Smo inhibitors with high potency and to which the acylguanidine MRT-83 belongs. This inhibitor perfectly fits with the proposed pharmacophoric model for Smo antagonists. The discrete structural differences between MRT-83 and the original leads may account for the increased potency of MRT-83 observed in various in vitro Shh-based assays.MRT-83 inhibits BODIPY-cyclopamine binding to human Smo and Shh-mediated proliferation of rat granule cell proliferation with nanomolar potency similar to GDC-0449 or LDE-225. Despite significant homology of Smo with the Frizzled family of receptors which are involved in the Wnt signaling pathway, MRT-83 displays no significant effect on this pathway. MRT-83 blocks Smo translocation induced by Shh pathway activation to the primary cilia of NT2 cells that derive from a pluripotent testicular carcinoma whereas cyclopamine, a reference Smo antagonist, induces Smo accumulation of Smo signals at the primary cilium. Therefore, it might be anticipated that MRT-83, like GDC-0449 and LDE-225, interacts with Smo in a manner different from that of cyclopamine, suggesting that while their binding sites are overlapping, they are not identical. Stereotaxic injection of MRT-83 into the lateral ventricle of adult mice but not of a structurally-related compound inactive at Smo, abolished upregulation of Ptc transcription induced by Shh in the neighboring subventricular zone, one of the two main neurogenic areas of the adult brain. These data demonstrate that MRT derivatives efficiently antagonize Shh signaling in vivo.Thus, MRT-10, MRT-14, MRT-83 and structurally-related molecules are potent Smo antagonists. These compounds should be useful for clarifying the molecular and biochemical mechanisms underlying the resistance of Smo inhibitors in brain cancer cells and may help develop new therapies against Shh pathway-related brain diseases.
Zones, contracts and absorbing changes (1999)

This paper describes a novel approach to managing the evolution of distributed, persistent systems at run-time. This is achieved by partitioning a system into disjoint zones, each of which can be evolved without affecting code in any other. Contracts are defined between zones, making type-level interdependencies and inter-zone communication explicit. Programmer supplied code is added to the running system, at the boundary between zones, to constrain the scope of changes. A change methodology is presented which the software engineer uses to help describe and manage the evolution of the system. Knowledge of the application semantics is essential when evolving a system and our approach allows the engineer to concentrate on these semantic aspects of change. Our Java-based demonstration platform and methodology reduce or remove some of the burdensome tasks the software engineer is normally expected to perform when changing a system, making evolution more tractable.
ChemInform Abstract: A Kulinkovich Entry into Tertiary N‐Acyliminium Ion Chemistry. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Openflow random host mutation (2012)

Static configurations serve great advantage for adversaries in discovering network targets and launching attacks. Identifying active IP addresses in a target domain is a precursory step for many attacks. Frequently changing hosts' IP addresses is a novel proactive moving target defense (MTD) that hides network assets from external/internal scanners. In this paper, we use OpenFlow to develop a MTD architecture that transparently mutates host IP addresses with high unpredictability and rate, while maintaining configuration integrity and minimizing operation overhead. The presented technique is called OpenFlow Random Host Mutation (OF-RHM) in which the OpenFlow controller frequently assigns each host a random virtual IP that is translated to/from the real IP of the host. The real IP remains untouched, so IP mutation is completely transparent for end-hosts. Named hosts are reachable via the virtual IP addresses acquired via DNS, but real IP addresses can be only reached by authorized entities. Our implementation and evaluation show that OF-RHM can effectively defend against stealthy scanning, worm propagation, and other scanning-based attack.
Scalable Techniques for Clustering the Web. (2000)

Clustering is one of the most crucial techniques for dealing with the massive amount of information present on the web. Clustering can either be performed once offline, independent of search queries, or performed online on the results of search queries. Our offline approach aims to efficiently cluster similar pages on the web, using the technique of Locality-Sensitive Hashing (LSH), in which web pages are hashed in such a way that similar pages have a much higher probability of collision than dissimilar pages. Our preliminary experiments on the Stanford WebBase have shown that the hash-based scheme can be scaled to millions of urls. 1.
Valorization of municipal organic waste into purified lactic acid (2021)

Municipal organic waste (biowaste) consists of food derived starch, protein and sugars, and lignocellulose derived cellulose, hemicellulose, lignin and pectin. Proper management enables nutrient recycling and sustainable production of platform chemicals such as lactic acid (LA). This review gathers the most important information regarding use of biowaste for LA fermentation covering pre-treatment, enzymatic hydrolysis, fermentation and downstream processing to achieve high purity LA. The optimal approach was found to treat the two biowaste fractions separately due to different pre-treatment and enzyme needs for achieving enzymatic hydrolysis and to do continues fermentation to achieve high cell density and high LA productivity up to 12 g/L/h for production of both L and D isomers. The specific productivity was 0.4 to 0.5 h<sup>-1</sup> but with recalcitrant biomass, the enzymatic hydrolysis was rate limiting. Novel purification approaches included reactive distillation and emulsion liquid membrane separation yielding purities sufficient for polylactic acid production.
Validating the Allogeneic Stem Cell Transplantation Disease Risk Index (2014)

The DRI is a simple, robust pre-alloHSCT risk stratification tool. However, users should calibrate with local data before using the DRI to estimate absolute OS, PFS, and CIR and understand its limitations when applied to smaller cohorts or cohorts with shorter follow-up.
Protein Transport in Nanoporous Membranes Modified with Self-Assembled Monolayers of Functionalized Thiols (2002)

Control of external pH and ionic strength is used to separate proteins with surface-modified, nanoporous polycarbonate track etched (PCTE) membranes. The porous PCTE membranes were modified with monolayers of self-assembled thiols (HSC10H20COOH) on electroless gold. The hydraulic radius of the pores in the surface-modified membranes was 8.7 nm. Two proteins of nearly identical molecular weight, bovine serum albumin (BSA) and bovine hemoglobin (BHb), were used as the permeants. The fluxes of BSA and BHb through the membranes show maximum values at the isoelectric points (pI) of the proteins. At pH values above and below the pI, charge interactions between the proteins, their counterions, and the pore surface leads to a decrease in flux. The imposition of a difference in ionic strength across the membrane causes osmotic flow and leads to a significant increase in the protein fluxes and an enhancement of the selectivity of BSA over BHb. In protein separation experiments, the BSA and BHb fluxes are nearly 3 times larger than those observed with no ionic strength difference.
TOWARDS AUTOMATIC DETECTION IN PANCREATIC EUS: AN ASSESSMENT OF DEEP LEARNING METHODS (2022)

Aims Pancreatic cancer is rarely detected at its early stages, when it’s curable, which leads to high mortality rates. Endoscopic ultrasound (EUS) is the best technique available nowadays to detect pancreatic cancer lesions smaller than 10 mm, which are amenable for surgical resection and
Etude de la relation structure/fonction de l'enzyme de synthèse de l'inositol 1,3,4,5- tétrakisphosphate : l'inositol 1,4,5- trisphosphate 3-kinase (1995)

Doctorat en Sciences
General Strategy for Ordered Noncovalent Protein Assembly on Well-Defined Nanoscaffolds (2013)

Here we develop a novel approach allowing the noncovalent assembly of proteins on well-defined nanoscaffolds such as virus particles. The antibody-binding peptide Z33 was genetically fused to the monomeric yellow fluorescent protein and 4-coumarate:CoA-ligase 2. This Z33 "tag" allowed their patterning on the surface of zucchini yellow mosaic virus by means of specific antibodies directed against the coat protein of the virus. The approach was validated by affinity assays and correlative microscopy. The coverage efficiency was ≈ 87%. Fluorescence and enzymatic activity were fully retained after assembly. The principle of using the combination of a scaffold-specific antibody and Z33-fusion proteins can be extended to a wide variety of proteins/enzymes and antigenic scaffolds to support coupling for creating functional "biochips" with optical or catalytic properties.
Anticipative Shared Control for Robotic Wheelchairs Used by People with Disabilities (2015)

Patients with neurological disorders are often required to cope with off-putting and longer rehabilitation process and some of them become wheelchair users with severe restriction on the arms and hands skill. Many studies have proposed solutions for autonomous or semi-autonomous powered wheelchairs focusing on navigation problems. In this project, we are interested in bringing up a planning shared control model for wheelchair to be used by people with disabilities or inexpert users to move from a room to another into an indoor place. The main objective is to reduce the effort of the users on controlling the wheelchair on these dedicated paths. This leads us to improve an algorithm of shared control to use other data sources such as agendas, travelled path, pose of the wheelchair, and time of day to infer patterns of conduction, in order to anticipate the conductor's intentions, for example, his/her intended path or final destination and to communicate with the user providing smart suggestions during the process. This anticipative shared control is of prime importance when tiring human-machine interfaces such as BCI, eye-tracking or EMG are being employed.
Transparent pigments (2021)

Abstract Transparent pigments are characterized by very small particles with sizes in the range below 100 nm and large specific surface areas. Most of the technically relevant pigments consist of inorganic compounds. Transparent pigments are classified as nanomaterials. Nanosized primary particles do not or only slightly scatter visible light, which is the reason for their transparency. Pigmentation with these pigments leads to a transparent appearance of the application systems. There are colored and colorless transparent pigments. If colored pigments such as α-FeOOH, α-Fe2O3, and CoAl 2 O 4 are used, the application medium takes on color while remaining transparent. Colorless transparent pigments are nearly invisible in the application system. Only in combination with effect pigments or conventional colored pigments, effects with a special appearance are possible, e.g., frost effects. There are two industrially relevant colorless transparent pigments, TiO 2 and ZnO. Both pigments find their main applications as functional powders. They are characterized by strong UV absorption and are therefore applied as UV absorbers. As such, they are used for the protection of organic materials such as plastics and coatings. They are used in addition in a broad diversity of sun screen products where they protect human skin. The manufacture of transparent pigments takes place mostly using wet-chemical or gas-phase reactions.
Characterization of the mechanical properties of a dermal equivalent compared with human skin in vivo by indentation and static friction tests (2008)

This original bio-tribometer shows the ability to assess the skin elasticity and friction force in a wide range of light normal load (0.5-2 g) and low contact pressure (0.5-2 kPa). The results obtained by this approach show identical values of the Young's modulus E(*) and the shear modulus G(*) of six DEs obtained from a 62-year-old subject (E(*)=8.5+/-1.74 kPa and G(*)=3.3+/-0.46 kPa) and in vivo total skin of 20 subjects aged 55 to 70 years (E(*)=8.3+/-2.1 kPa, G(*)=2.8+/-0.8 kpa).
Band structure calculation of the two-photon absorption coefficient and nonlinear refractive index in semiconductors (1990)

Although the field of nonlinear optics has seen tremendous growth in the past few years, the number of full band structure calculations of the nonlinear optical properties of even just bulk homogeneous semiconductors is extremely small.
Development of silk/polycaprolactone biocomposite for internal bone plate application (2019)

In this work, the stacking of different layers of silk fabric reinforced polycaprolactone biocomposites were prepared by compression moulding technique. The mechanical and biodegradation behaviour were investigated. The mechanical properties of the different layers of silk/polycaprolactone composite were observed. The 14 layers of silk/polycaprolactone composites showed higher mechanical properties when compared to other composites. This was due to its sufficient mechanical interlocking between the fabric and the matrix. Further, scanning electron microscopy analysis confirmed the good interfacial bonding between silk and polycaprolactone. The in-vitro degradation study revealed that silk/polycaprolactone composite uptakes more water due to hydrophilic nature of silk while polycaprolactone showed higher amount of weight loss. Though there was a decrease in trend in the tensile properties of composite, still they can be used as a biodegradable plate due to its adequate mechanical strength. The changes in pH of the composite were also noticed and found negligible. Thus, the biodegradable silk/polycaprolactone composites are a promising alternative implant for patients, as they provide temporary mechanical support and controlled rate of biodegradation for the bone plate application.
Fat content during attack and brood production of the ambrosia beetle Trypodendron lineatum (Oliv.) (2019)

Volume: 66
Structure of a CBS-domain pair from the regulatory γ1 subunit of human AMPK in complex with AMP and ZMP (2007)

AMP-activated kinase (AMPK) is central to sensing energy status in eukaryotic cells via binding of AMP and ATP to CBS (cystathionine beta-synthase) domains in the regulatory gamma subunit. The structure of a CBS-domain pair from human AMPK gamma1 in complex with the physiological activator AMP and the pharmacological activator ZMP (AICAR) is presented.
A familial factor independent of CAG repeat length influences age at onset of Machado-Joseph disease. (1996)

Machado-Joseph disease (MJD) is a late-onset, progressive, neurodegenerative disorder caused by the expansion of an unstable trinucleotide (CAG) repeat sequence in a novel gene (MJD1) on chromosome 14. Previous studies showed that age at onset is negatively correlated with the number of CAG repeat units, but only part of the variation in onset age is explained by CAG repeat length. Ages at onset and CAG repeat lengths of 136 MJD patients from 23 kindreds of Portuguese descent were analyzed, to determine whether familial factors independent of CAG repeat length modulate age at onset of MJD. Correlation among sibs for onset age adjusted for CAG repeat length was .43, which indicates that an environmental or genetic factor common to sibs influences onset age. Positive correlations were also observed for avuncular (r = .22) and first-cousin pairs (r = .28), which supports the hypothesis that a genetic factor is influencing age at onset. Commingling analysis of onset ages adjusted for CAG repeat length identified three distributions in this population of affected individuals. Further studies of a much larger sample are needed to determine whether these distributions represent the influence of a genetic or environmental factor.
Tetanus toxin preserves skeletal muscle contractile force and size during limb immobilization (2014)

Tetanus toxin prevented common signs of muscle atrophy and may become a useful adjunct to current rehabilitation strategies.
ChemInform Abstract: Meta‐Stable Phases in the Mn—Ta—O System. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Adaptive wideband beamforming with robustness against presteering errors (2006)

We develop a wideband adaptive beamformer with an improved robustness against presteering errors. The proposed beamformer employs the presteered broadband array processor and models the uncertainty in the array manifold as norm-bounded phase errors at the outputs of the presteering delay filters. A state-space model is developed for this robust beamforming problem, and an extended Kalman filter (EKF) is used to estimate the beamformer weight vector adaptively with a low computational complexity.
Characterization and snubbing of a bidirectional MCT switch in a resonant AC link converter (1995)

The MOS-controlled thyristor (MCT) is emerging as a powerful switch that combines the characteristics of existing power devices. This paper presents a study of switching stresses on the MCT under zero voltage resonant switching. Two MCTs and two diodes are connected to form a bidirectional switch which was used in an AC/AC resonant link inverter. Current and voltage spikes are observed and analyzed with variations in the timing of the MCT switching. Different snubber circuit configurations are investigated to minimize the effect of these transients. Some failure modes of the device are also presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Machine Anomaly Detection and Diagnosis Incorporating Operational Data Applied to Feed Axis Health Monitoring (2011)

Solutions for machinery anomaly detection and diagnosis are typically designed on an ad hoc, custom basis, and previous studies have shown limited success in automating or generalizing these solutions. Reusing and maintaining the analysis software, especially when the machine usage pattern or operating condition changes, remains a challenge. This paper outlines a strategy to make use of operational data obtained from the machine’s controller and signals obtained from external sensors to provide an accurate analysis within each operating condition. Operational data collected from the controller is used both for labeling datasets into different operating conditions and for analysis. Principal component analysis (PCA) is adopted to identify critical sensors that can provide useful information. Self-organizing map (SOM)-based anomaly detection and diagnosis methods are used to automatically convert data to easily understandable machine health information for operators. Experiment trials conducted on a feed-axis test-bed demonstrated the effectiveness of incorporating operational data for anomaly detection and diagnosis.
The atypical chemokine receptor 3 interacts with Connexin 43 inhibiting astrocytic gap junctional intercellular communication (2020)

The atypical chemokine receptor 3 (ACKR3) plays a pivotal role in directing the migration of various cellular populations and its over-expression in tumors promotes cell proliferation and invasiveness. The intracellular signaling pathways transducing ACKR3-dependent effects remain poorly characterized, an issue we addressed by identifying the interactome of ACKR3. Here, we report that recombinant ACKR3 expressed in HEK293T cells recruits the gap junction protein Connexin 43 (Cx43). Cx43 and ACKR3 are co-expressed in mouse brain astrocytes and human glioblastoma cells and form a complex in embryonic mouse brain. Functional in vitro studies show enhanced ACKR3 interaction with Cx43 upon ACKR3 agonist stimulation. Furthermore, ACKR3 activation promotes β-arrestin2- and dynamin-dependent Cx43 internalization to inhibit gap junctional intercellular communication in primary astrocytes. These results demonstrate a functional link between ACKR3 and gap junctions that might be of pathophysiological relevance.
Development of a Process Simulation Model for the Analysis of the Loading and Unloading System of a CNG Carrier Equipped with Novel Lightweight Pressure Cylinders (2020)

Natural gas is becoming increasingly important to meet the growing demand for energy, guaranteeing a reduction in polluting emissions. Transportation in form of Compressed Natural Gas (CNG) could be an alternative to the traditional transportation by pipeline or, as liquefied gas, by ships, but the ratio between the mass of transported gas and the container weight is currently too low. One of the many projects focusing on the development of innovative lightweight pressure cylinders is GASVESSEL, which proposes composite cylinders with a diameter of more than 3 m: loaded on a ship, they could allow transporting quantities of CNG as big as 10,000 tons. The related loading and unloading processes affect both the overall time required for transport and the quantity of transported gas; therefore, they have an impact on the economic feasibility of the whole project. In this paper, a newly developed process simulation model is presented that allows assessing the duration of the loading and unloading processes, the mass of transported CNG, and the amount of power and energy required by the process. The model is useful to support the design of the system considering different plant components and operating strategies. It is applied to the analysis of the loading and unloading of a ship that meets the GASVESSEL project specifications. The results show that the duration of the process is of the order of magnitude of 100 h, depending on ambient temperature, and that the energy consumption can vary in the range of 150–180 kJ for a unit mass of CNG. Finally, the model is used to simulate the same process with hydrogen, an energy carrier that allows meeting, together with the use of fuel cells, the requirements of zero local emissions. The results show increments of both the final loading temperature and compressor power with respect to the CNG case.