gebhart/patrepeval huggingface dataset:
An Abnormal Inherited Fibrinogen (Fibrinogen Genova) with Delayed Fibrin Aggregation (1982)

A new autosomally inherited dysfibrinogenaemia was recognized in 3 members of an Italian family. No bleeding tendency or thrombotic disease in any of the affected members were demonstrated. Coagulation tests revealed prolonged prothrombin, thrombin and Reptilase times. Plasma fibrinogen levels were normal with immunologic method and slightly reduced with chronometric assay: the other blood coagulation factors were normal. In addition, cross-immunoelectrophoresis performed on patients' plasma was indistinguishable from the normal. Dysfibrinogenaemia was confirmed by studying the purified fibrinogen. The fibrin polymerization curve, measured spectrophotometrically, showed a lower slope than the normal. A delay in fibrin monomer aggregation was revealed when compared to the normal at an equal concentration. The release of fibrinopeptides was normal. SDS polyacrylamide gel electrophoresis, isoelectric focusing and cross-immunoelectrophoresis of purified fibrinogen were not able to demonstrate any structural abnormality. The fibrinogen was named fibrinogen Genova.
A Single-Institution Experience in Percutaneous Image-Guided Cryoablation of Lymph Node Metastases (2021)

<b>OBJECTIVE.</b> The purpose of this study was to assess the feasibility, safety, and efficacy of percutaneous cryoablation for the treatment of lymph node metastases. <b>MATERIALS AND METHODS.</b> In this single-institution retrospective study 55 patients were identified who underwent CT-guided cryoablation of metastatic lymph nodes between November 2006 and September 2019. Patient demographics, disease characteristics, and procedural details were recorded. The primary endpoints were technical success and major complications. The secondary endpoints were time to local and time to distant progression. Complications were graded according to the Society of Interventional Radiology consensus guidelines. <b>RESULTS.</b> The study sample comprised 55 patients (42 men, 13 women; mean age 64 ± 12 years) who underwent 61 cryoablation procedures to treat 65 lymph node metastases. Targeted nodes measured 1.7 ± 1.2 cm in mean short-axis diameter. Technical success was achieved in 60 of 61 cryoablation procedures (98%). Adjunctive maneuvers performed to protect adjacent structures included hydrodissection (<i>n</i> = 40), ureteral stenting (<i>n</i> = 3), and neural monitoring (<i>n</i> = 3). There were two Society of Interventional Radiology major complications (3%): pneumothorax (<i>n</i> = 1) and bleeding (<i>n</i> = 1). Local tumor control was achieved in treatment of 53 of 65 (82%) nodal metastases within a median of 25 months (range, 1-121 months) of follow-up. Local progression occurred in 12 of 65 cases (18%); the median time to recurrence was 11 months. <b>CONCLUSION.</b> Percutaneous cryoablation of nodal metastases is feasible and safe. Further investigation is warranted to assess the long-term efficacy of this technique and to define its role in oncologic care.
Research for brushless motor controller using winding back-EMF to detect rotor position (2008)

As BLDCM position sensor has the shortcomings of size, cost and the manufacturing technology, in this paper, electrodes winding back EMF signal detecting the back EMF zero point is used to acquire the motor rotor signal. The BLDCM position sensor control strategies is analyzed, low-power controller has been developed by using chip ML4425, in order to improve the current volatile problem under the start-up and load disturbance situation, the speed and the current dual-closure are achieved by a simple differential circuit. And the prototype was tested, test results show that the controller has good working properties.
Resolving Scale Ambiguity via XSlit Aspect Ratio Analysis (2015)

In perspective cameras, images of a frontal-parallel 3D object preserve its aspect ratio invariant to its depth. Such an invariance is useful in photography but is unique to perspective projection. In this paper, we show that alternative non-perspective cameras such as the crossed-slit or XSlit cameras exhibit a different depth-dependent aspect ratio (DDAR) property that can be used to 3D recovery. We first conduct a comprehensive analysis to characterize DDAR, infer object depth from its AR, and model recoverable depth range, sensitivity, and error. We show that repeated shape patterns in real Manhattan World scenes can be used for 3D reconstruction using a single XSlit image. We also extend our analysis to model slopes of lines. Specifically, parallel 3D lines exhibit depth-dependent slopes (DDS) on their images which can also be used to infer their depths. We validate our analyses using real XSlit cameras, XSlit panoramas, and catadioptric mirrors. Experiments show that DDAR and DDS provide important depth cues and enable effective single-image scene reconstruction.
Aesthetically pleasing concrete combination pedestrian-traffic bridge rail - Texas type C411 (1991)

Research has developed railings to withstand impact loads from vehicles of ever-increasing size; however, aesthetic considerations have been overshadowed by safety and structural requirements. The objective of this research study was to develop aesthetically pleasing, structurally sound railings that can serve as alternative railings in city or urban areas. This report presents a new concrete combination pedestrian-traffic bridge rail - Texas Type C41 1. This bridge rail was constructed of reinforced concrete 42 in. high by 12 in. thick and contains 6 in. wide by 28 in. high openings at 18 in. center- to-center longitudinal spacing. The combination pedestrian-traffic bridge rail was located on a 6 ft wide sidewalk with 8 in. high curb separating it from the traffic. The bridge rail was developed for use on urban streets where the speed limit would be 45 mph or less. Service Level 1 of NCHRP 230 and Performance Level 1 of the 1989 AASHTO Guide Specifications for Bridge Railings were considered inappropriate. NCHRP Project C22-7, 'Update of Roadside Safety Hardware Crash Test Specifications, and NCHRP Project 12-33, Development of a Comprehensive Bridge Specification and Commentary, were seriously considering a different test matrix at the time these tests were conducted. It was decided to use a 4,500 lb car at 45 mph and 25 degree impact angle and an 1,900 lb car at 45 mph and 20 degree impact angle. The new C41 1 bridge rail performed very well under these two crash tests. The crash test results easily met the usual safety evaluation criteria. The C411 should be safe for use on low speed, 45 mph or less, roadways.
A phase 1b/2 study of napabucasin with weekly paclitaxel in advanced, previously treated non-squamous non-small cell lung cancer. (2017)

9052 Background: Napabucasin is a first-in-class cancer stemness inhibitor, identified by its ability to inhibit STAT3-driven gene transcription and spherogenesis of cancer stem cells (Li et al PNAS 112 (6):1839, 2015). Napabucasin has shown potent synergistic preclinical anti-tumor activity with paclitaxel (PTX). In a phase Ib dose escalation study in patients (pts) with advanced solid tumors, napabucasin plus weekly PTX was well tolerated. A phase II expansion cohort was opened for pts with advanced non-small cell lung cancer (NSCLC). Methods: Pts with metastatic non-squamous NSCLC were enrolled to confirm safety and preliminary anti-cancer activity. Prior platinum-based systemic therapy was required, and patients with an EGFR or ALK mutation required appropriately targeted therapy. Napabucasin was administered orally at a starting dose of 240 or 480 mg BID with PTX 80 mg/m2 IV weekly 3 of every 4 weeks. AEs were evaluated using CTCAE v4.03 and objective assessments were performed every 8 weeks per RECIST 1.1. Results: A cohort of 23 pts with advanced non-squamous NSCLC was evaluated. The median number of prior systemic treatment lines was 3, including taxane-based therapy in 100% and immune checkpoint inhibitor in 48% (n = 11). Treatment was well tolerated; related grade 3 AE included diarrhea (n = 4) and fatigue (n = 1). The objective response rate was 26% (6 partial responses [PR]) and the disease control rate (DCR; proportion with SD at 8 weeks plus PR per RECIST) was 70% (n = 16). Tumor regression, including PR, occurred in 35% (n = 8). The median progression-free survival (mPFS) was 5.4 months, and 43% (n = 10) of pts were alive and free of progression at the 24 week time-point or longer. The median overall survival (mOS) was 11.0 months, and 30% (n = 7) of pts were alive for 52 weeks or longer. Conclusions: Clinical safety and encouraging signs of anti-cancer activity were observed in pts with heavily pretreated non-squamous NSCLC who received napabucasin plus weekly paclitaxel. The objective response rate, progression free survival, and overall survival in this population warrant further clinical evaluation and a controlled phase 2/3 trial (CanStem43L) has been initiated. Clinical trial information: NCT01325441.
Track-following control of hard disk drives using multi-rate sampled-data H/sub ?/ control (2004)

In hard disk drives (HDDs), the sampling period of a position error signal (PES) is restricted. Thus, the multi-rate control design has been a popular subject in HDDs. This paper proposes a design method of read/write head-positioning controller using multi-rate sampled-data H/sub /spl infin// control theory. This method can design multi-rate controller directly considering inter-sample performance and robust stability. The structure of generalized plant and the selection of weighting functions are discussed. The obtained performance is compared with the single-rate sampled-data H/sub /spl infin// controller and single-rate/multi-rate discrete-time H/sub /spl infin// controller through experimentation.
CMOS/CCD sensors and camera systems (2007)

This update to CCD Arrays, Cameras, and Displays (2nd Ed.) addresses CMOS/CCD differences, similarities, and applications, including architecture concepts and operation, such as full-frame, interline transfer, progressive scan, color filter arrays, rolling shutters, 3T, 4T, 5T, and 6T. The authors discuss novel designs, such as EMCCD, EBCCD, Super CCD, and intensified CCDs, illustrate sampling theory and aliasing with numerous examples, and describe the advantages and limitations of small pixels. This monograph provides the background necessary for specifying cameras using radiometric or photometric concepts, in addition to information on the entire system--from scene to observer.
High-fidelity two-qubit gates in silicon above one Kelvin (2020)

Spin qubits in quantum dots define an attractive platform for scalable quantum information because of their compatibility with semiconductor manufacturing, their long coherence times, and the ability to operate at temperatures exceeding one Kelvin. Qubit logic can be implemented by pulsing the exchange interaction or via driven rotations. Here, we show that these approaches can be combined to execute a multitude of native two-qubit gates in a single device, reducing the operation overhead to perform quantum algorithms. We demonstrate, at a temperature above one Kelvin, single-qubit rotations together with the two-qubit gates CROT, CPHASE and SWAP. Furthermore we realize adiabatic, diabatic and composite sequences to optimize the qubit control fidelity and the gate time. We find two-qubit gates that can be executed within 67 ns and by theoretically analyzing the experimental noise sources we predict fidelities exceeding 99%. This promises fault-tolerant operation using quantum hardware that can be embedded with classical electronics for quantum integrated circuits.
[A case of left inguinal malignant lymphoma occurred after radical operation for gastric cancer and gastrointestinal stromal tumor]. (2009)

In March 2005, a 70-year-old male patient underwent distal gastrectomy with D2 lymph node dissection for type 3 gastric cancer located in the lower-third of the stomach, and partial gastrectomy for submucosal tumor located in the upper- third of the stomach. A post operative pathological finding of cancer was T2N0P0H0M0 (f-Stage II) and that of submucosal tumor was gastrointestinal stromal tumor. Although the adjuvant chemotherapy of S-1 was administered, it was discontinued because of cerebral infarction. Forty months after the operation, CT scan revealed a left inguinal lymph node swelling and recurrence of gastric cancer was doubted. FDG-PET scan confirmed increased uptake only in one lymph node of left inguinal region. In September 2008, left inguinal lymph node dissection was performed and its pathological finding was follicular lymphoma (grade 1). At present, the patient was doing well and showed no signs of recurrence. However, it is important to follow-up the patient carefully because the relapse rate of follicular lymphoma is comparatively high.
Beschreibung von Zufallssignalen (1997)

ZusammenfassungBei allen bisherigen Betrachtungen über kontinuierliche und diskrete Signale und ihre Beschreibung in Zeit- und Frequenzbereich waren wir immer von Signalverläufen ausgegangen, die durch mathematische Funktionen beschreibbar waren. Damit konnten wir mit den Werten der Signalverläufe rechnen, Signale addieren und subtrahieren, verzögern und schließlich Ableitungen und Integrale bilden. Gerade von der Integration hatten wir häufig Gebrauch gemacht, als Faltung, als Fourier- und Laplace-Transformation und als komplexe Integration für die inverse Laplace- und die inverse z-Transformation. Bei diskreten Signalen traten endliche und unendliche Summen an die Stelle der Integrale. Dies alles war nur möglich, weil wir angenommen hatten, daß jedes vorkommende Signal zu jedem Zeitpunkt einen eindeutig bestimmbaren Wert besitzt, der durch — möglicherweise komplizierte — mathematische Formeln beschrieben werden kann.
Powering mm-Size Wireless Implants for Brain-Machine Interfaces (2011)

Over the last couple of years, Brain-Machine Interfaces (BMI) based on microelectrode arrays have been shown to have the potential to substantially improve the quality of life for people suffering from debilitating conditions such as spinal cord injuries or limb loss. One of the most critical parts of a BMI system is the neural sensor. It is ideally implanted underneath the skull, reads out neural signals from the brain and transmits them wirelessly to a receiver outside the skull. The requirements on the electronics of such a sensor are extremely stringent, especially with respect to size and power consumption. Ideally, the overall size of the implanted sensor node is limited by the size of the sensor itself, rather than the electronics and the power source. &lt;p&gt;This work investigates powering options for implants of sizes ranging from 10 mm by 10 mm down to 1 mm by 1 mm. Wireless power transfer is identified as the most promising option of doing so and is investigated in detail. It is shown, that for a given implant antenna size, an optimum combination of external antenna and frequency of operation exists that minimizes the overall link loss. In combination with limitations on the maximum transmit and received power due to health concerns, the maximum power available to mm-size implants as a function of size is derived. Two different AC-to-DC conversion circuit topologies, covering the expected input power and frequency range, are analyzed in detail and design guidelines for each are given. &lt;p&gt;Finally, a 1 mm^3 proof-of-concept implementation of a wirelessly powered neural transponder is presented. It was tested in air and in animal and provides enough extra DC power to power a neural sensor front-end while supporting a 2 Mbps radio link. The presented tag is the smallest wireless neural tag reported to date and prooves the feasibility of remotely powered mm-size wireless neural implants.
A new approach for massive parallel scan design (2006)

This paper proposes a new signaling method for efficient scan design based on the dual use of on-chip power lines. The proposed signaling scheme intends to increase the channel capacity for the multiple parallel scan design, and we suggest adoption of the UWB (ultra wideband) and direct sequence-code division multiple access (DS-CDMA) communication technologies. Because of the wide bandwidth, a UWB signal can reduce its average power level practically to the noise level. The DS-CDMA further mitigates the noise and allows multiple scan inputs to share the interconnected power lines. We studied the feasibility of the proposed scheme through SPICE simulations and present the simulation results for a power distribution networks consisting of two metal layers.
Para-acyl calix[4]arenes: amphiphilic self-assembly from the molecular to the mesoscopic level (2002)

Studies of the properties of a series of amphiphilic calixarenes show that they can form stable monolayers, Langmuir-Blodgett layers and solid lipid nanoparticles, the mesostructures were investigated by atomic force microscopy and the crystal structure of one compound shows a partially interdigitated tilted bilayer structure.
Efficient resource allocation in mobile-edge computation offloading: Completion time minimization (2017)

Mobile-edge computation offloading (MECO) is a promising solution for enhancing the capabilities of mobile devices. For an optimal usage of the offloading, a joint consideration of radio resources and computation resources is important, especially in multiuser scenarios where the resources must be shared between multiple users. We consider a multi-user MECO system with a base station equipped with a single cloudlet server. Each user can offload its entire task or part of its task. We consider parallel sharing of the cloudlet, where each user is allocated a certain fraction of the total computation power. The objective is to minimize the completion time of users' tasks. Two different access schemes for the radio channel are considered: Time Division Multiple Access (TDMA) and Frequency Division Multiple Access (FDMA). For each access scheme, we formulate the corresponding joint optimization problem and propose efficient algorithms to solve it. Both algorithms use the bisection-search method, where each step requires solving a feasibility problem. For TDMA, the feasibility problem has a closed-form solution. Numerical results show that the performance of offloading is higher than of local computing. In particular, MECO with FDMA outperforms MECO with TDMA, but with a small margin.
Distributed and Heterogeneous SAR Backprojection with Halide (2021)

Writing efficient, scalable, and portable HPC synthetic aperture radar (SAR) applications is increasingly challenging due to the growing diversity and heterogeneity in distributed systems. Considerable developer and computational resources are often spent to port applications to new HPC platforms and architectures, which is both time consuming and expensive. Domain-specific languages have been shown to be highly productive for development effort, but additionally achieving both scalable computational efficiency and platform portability remains challenging. The Halide programming language is both productive and efficient for dense data processing, supports common CPU architectures and heterogeneous resources like GPUs, and has previously been extended for distributed processing. We propose to use a distributed Halide implementation for scalable and heterogeneous HPC SAR processing. We implement a backprojection algorithm for SAR image reconstruction and demonstrate scalability on the OLCF Summit supercomputer up to 1,024 compute nodes (43,008 cores, each with 4 hardware threads) with a large 32,768×32,768 dataset, and up to 8 distributed GPUs with a 8,192×8,192 dataset. Our results show excellent scaling and portability to heterogeneous resources, and motivate additional improvements in Halide to better support distributed high-performance signal processing.
Severe hemolytic disease of the newborn due to anti-Di b treated with phototherapy and intravenous immunoglobulin. (2008)

The Di(b) antigen usually occurs with high incidence, except in certain Asian and South American Indian populations. In general, hemolysis caused by anti-Di(b) is not severe and its clinical course is benign. We report a Korean neonate with severe hemolytic disease of the newborn caused by anti-Di(b). The phenotype and genotype of the Diego blood group system of the patient and his mother were Di(a+b+) and Di(a+b-), respectively. The mother's serum and eluate from the neonate's erythrocytes contained anti-Di(b). This case was successfully managed with phototherapy and high dose iv immunoglobulin. Since most commercial antibody detection panels do not contain Di(b-) red cells, it is important to consider anti-Di(b) in cases of hemolytic disease of the newborn caused by an antibody against a high frequency antigen.
A Case Study on Condenser Water Supply Temperature Optimization with a District Cooling Plant (2021)

District cooling (DC) continues to proliferate due to increasing global cooling demands and economies of scale benefits; however, most district-scale modeling has focused on heating, and to the best of our knowledge, researchers have yet to model cooling plants featuring waterside economizers in DC settings. With the Modelica Buildings library expanding its capabilities to district scale, this study is one of the first to demonstrate how the open-source models can be used for detailed energy and control analysis of a DC plant. For a real-world case study, we developed and calibrated high-fidelity models for a DC system central plant at a college campus in Colorado, USA, and we optimized the condenser water supply temperature (CWST) setpoint for a DC plant across multiple time horizons using the Optimization library in Dymola. Results indicate that annual CWST optimization saves 4.7% annual plant energy, with less than 1% of additional energy savings gained through daily optimization. This confirms previous studies' findings that high frequency CWST optimizations are not necessary for the studied system.
THE CYTOKINE AND HISTOLOGICAL RESPONSE IN ISLET XENOGRAFT REJECTION IS DEPENDENT UPON SPECIES COMBINATION1 (1997)

The mouse used different mechanisms to reject the rat and canine islets, suggesting that the immune response in islet xenograft rejection may be dependent on the species combination. It may not be possible to characterize the cellular xenograft rejection response in a bipolar manner as has been the case with humoral rejection response. Caution therefore needs to be taken before extrapolating the cellular immune responses seen in animal models to the clinical setting.