gebhart/patrepeval huggingface dataset:
CAR T Cells in Solid Tumors: Blueprints for Building Effective Therapies (2018)

Genetic redirection of T lymphocytes with chimeric antigen receptors (CARs) has soared from treating cancers preclinically to FDA approval for hematologic malignancies and commercial-grade production scale in under 30 years. To date, solid tumors are less susceptible to CAR therapies and instead have been treated more successfully with immune checkpoint blockade or tumor-infiltrating lymphocyte therapy. Here, we discuss the current challenges in treating solid tumors with CAR T cells, and the obstacles within the host and tumor microenvironment hindering their efficacy. We present a novel three-pronged approach for enhancing the efficacy of CAR T cells whereby a single infusion product can synergize the power of an optimal CAR construct, a highly potent T cell subset, and rejuvenate the endogenous immune response to conquer therapeutically-resistant solid tumors.
Wave reflections from duct terminations (2001)

The reflection coefficients and inertial end corrections of several duct terminations, including finite length duct extensions perpendicular to an infinite wall, as well as at a number of angles, curved interface surfaces, and annular cavities, are determined and analyzed in the absence of flow by employing the boundary element method. Predictions for the classical unflanged and flanged circular ducts show good agreement with analytical and computational results available in the literature. The predictions for curved interface surfaces (bellmouth or horn) are also consistent with the available experimental data. In view of its high reflection coefficient, the duct termination with an annular cavity may be suggested for the suppression of noise radiation in a specific frequency band or for an effective wave reflection from the termination.
Integral LOS Path Following for Curved Paths Based on a Monotone Cubic Hermite Spline Parametrization (2014)

This paper addresses two interrelated problems concerning the planar three degree-of-freedom motion of a vehicle, namely, the path planning problem and the guidance problem. The monotone cubic Hermite spline interpolation (CHSI) technique by Fritsch and Carlson is employed to design paths that provide the user with better shape control and avoid wiggles and zigzags between the two successive waypoints. The conventional line-of-sight (LOS) guidance law is modified by proposing a time-varying equation for the lookahead distance, which is a function of the cross-track error. This results in a more flexible maneuvering behavior that can contribute to reaching the desired path faster as well as obtaining a diminished oscillatory behavior around the desired path. The guidance system along with a heading controller form a cascaded structure, which is shown to be κ-exponentially stable when the control task is to converge to the path produced by the aforementioned CHSI method. In addition, the issue of compensating for the sideslip angle β is discussed and a new κ-exponentially stable integral LOS guidance law, capable of eliminating the effect of constant external disturbances for straight-line path following, is derived.
Annotation Guidelines BIONLP-ST 2016 SeeDev task (2016)

Livret Guide
Parathyroid-hormone-related protein: a previously unrecognized renal vasodilator (1995)

Nephropathy) will evaluate the effect of cyclosporin A versus no immunosuppressive treatment in 186 patients with idiopathic membranous nephropathy, reduced renal function (creatinine clearance <60 ml/min/1.73 m 2 ) and persistent nephrotic syndrome with a followup of 3.5 years [14]. Participation of many centres is warmly welcomed in order to achieve the goals of these studies so that some parts of the dilemma of the treatment of idiopathic membranous nephropathy can be solved in a collaborative European effort.
Copper–Peptide Complex Structure and Reactivity When Found in Conserved His-Xaa-His Sequences (2014)

Oxygen-activating copper proteins may possess His-X(aa)-His chelating sequences at their active sites and additionally exhibit imidiazole group δN vs εN tautomeric preferences. As shown here, such variations strongly affect copper ion's coordination geometry, redox behavior, and oxidative reactivity. Copper(I) complexes bound to either δ-HGH or ε-HGH tripeptides were synthesized and characterized. Structural investigations using X-ray absorption spectroscopy, density functional theory calculations, and solution conductivity measurements reveal that δ-HGH forms the Cu(I) dimer complex [{Cu(I)(δ-HGH)}2](2+) (1) while ε-HGH binds Cu(I) to give the monomeric complex [Cu(I)(ε-HGH)](+) (2). Only 2 exhibits any reactivity, forming a strong CO adduct, [Cu(I)(ε-HGH)(CO)](+), with properties closely matching those of the copper monooxygenase PHM. Also, 2 is reactive toward O2 or H2O2, giving a new type of O2-adduct or Cu(II)-OOH complex, respectively.
Mobile Communications: Within the Deepwater Lifelines (2014)

This thesis researched the availability and applicability of using commercial off-the-shelf (COTS) cellular software and smartphone hardware platforms to address future individual communication requirements for the US Navy at sea. The paper presents evidence in favor of incorporation of COTS technology aboard ships to address tactical communications. Individual communication needs facilitated by devices include text, chat, voice, position location information, imagery and map viewing, streaming video, web browsing and e-mail. While all of these identified communication capabilities are currently available in military command and control systems, they presently reside primarily at hardwired workstations requiring large assets to maintain. The paper also studies current research in micro mobile communication networks that have been growing exponentially in the past year including a host of different network types: ad hoc, smartphone, access point, sensor, etc. The paper lays out a solid understanding of all layers of wireless networking and the interactions between them (including physical, data link, medium access control, routing, transport, and application). The topics of security, efficiency, mobility, health risk, scalability, and their unique characteristics in wireless networks are discussed. Finally, the researcher explores advanced architectures, protocols, and satellite support for complex, dynamic, developing recursive network architectures, protocols, and looks at devices for complex, dynamic, high-performance communication in hostile and extremely remote locations such as the high sea.
A38 Nikken Major Dream Pro-Endmill Arbor & Pro-Endmill Head (2008)

The cutter arbor with BT shank and the cutter head are separated from the conventional mono block style cutter with BT shank. The connection interface between arbor and cutter head are equivalent to the DEPO style popular in Europe. The cutter arbor has the dampening mechanism built-in the BT shank and the machine spindle interface is double face contact of taper and flange.
A concept for virtual reality tools for design reviews (1998)

The paper discusses a concept for virtual reality tools for use in design reviews of mechanical products. In this discussion, the special requirements of a virtual environment are given consideration. The focus of this paper is on suggestions for the visualization and arrangement of a product, its structure, its components and their alternatives together in one environment. The realization of these concepts results in a 3D-interface that allows users, especially engineers, to evaluate different configurations of a product and gives them direct access to the product structure. By applying various visualization techniques, product components and their attributes, e.g., their price, can be brought together into one visualization. Thus, in contrast to state-of-the-art software, the product structure, three-dimensional, real-sized components, and attribute values can be combined together in 3D-visualizations. This research was done in cooperation with Christoph Brandt, member of the Heinz Nixdorf Institute's virtual reality group.
ChemInform Abstract: α‐Activated Cross Conjugated Cycloalkenone Systems in Organic Synthesis (2014)

Abstract Review: 85 refs.
Explicit Constructions of Depth-2 Majority Circuits for Comparison and Addition (1994)

All Boolean variables here range over the two-element set $\{ - 1,1 \}$. Given n Boolean variables $x_1 , \ldots ,x_n $, a nonmonotone MAJORITY gate (in the variables $x_i $) is a Boolean function whose value is the sign of $\Sigma _{i = 1}^n \varepsilon _i x_i $, where each $ \varepsilon _i $ is either 1 or $ - 1$. The COMPARISON function is the Boolean function of two n-bits integers X and Y whose value is $ - 1$ if and only if $X\geqq Y$. An explicit sparse polynomial whose sign computes this function is constructed. Similar polynomials are constructed for computing all the bits of the summation of the two numbers X and Y. This supplies explicit constructions of depth-2 polynomial-size circuits computing these functions, which use only nonmonotone MAJORITY gates. These constructions are optimal in terms of the depth and can be used to obtain the best-known explicit constructions of MAJORITY circuits for other functions like the product of two n-bit numbers and the maximum of nn-bit numbers. A crucial ingredient is the construction of a discrete version of a sparse “delta polynomial”—one that has a large absolute value for a single assignment and extremely small absolute values for all other assignments.
Simulating quantum operations with mixed environments (1999)

We study the physical quantum resources required to implement general quantum operations, and provide bounds on the minimum possible size which an environment must be in order to perform certain quantum operations. We prove that contrary to a previous conjecture, not all quantum operations on a single qubit can be implemented with a single-qubit environment, even if that environment is initially prepared in a mixed state. We show that a mixed single-qutrit environment is sufficient to implement a special class of operations, the generalized depolarizing channels.
DynaMat (1999)

Pre-computation and materialization of views with aggregate functions is a common technique in Data Warehouses. Due to the complex structure of the warehouse and the different profiles of the users who submit queries, there is need for tools that will automate the selection and management of the materialized data. In this paper we present DynaMat, a system that dynamically materializes information at multiple levels of granularity in order to match the demand (workload) but also takes into account the maintenance restrictions for the warehouse, such as down time to update the views and space availability. DynaMat unifies the view selection and the view maintenance problems under a single framework using a novel “goodness” measure for the materialized views. DynaMat constantly monitors incoming queries and materializes the best set of views subject to the space constraints. During updates, DynaMat reconciles the current materialized view selection and refreshes the most beneficial subset of it within a given maintenance window. We compare DynaMat against a system that is given all queries in advance and the pre-computed optimal static view selection. The comparison is made based on a new metric, the Detailed Cost Savings Ratio introduced for quantifying the benefits of view materialization against incoming queries. These experiments show that DynaMat's dynamic view selection outperforms the optimal static view selection and thus, any sub-optimal static algorithm that has appeared in the literature.
Adjuvant Peptide Pulsed Dendritic Cell Vaccination in Addition to T Cell Adoptive Immunotherapy for Cytomegalovirus Infection in Allogeneic Hematopoietic Stem Cell Transplantation Recipients (2017)

Adoptive cellular immunotherapy has been shown to be effective in the management of cytomegalovirus (CMV) reactivation and disease. Whether adjuvant dendritic cell (DC) vaccination will provide additional benefit in prophylaxis or treatment of CMV in hematoietic cell transplantation (HSCT) recipients is unknown. In this study, we administered prophylactic CMV-peptide specific T cell infusions, followed by 2 doses of intradermal CMV peptide-pulsed DC vaccine, to 4 HSCT recipients. There were no immediate adverse events associated with T cell infusion or DC vaccinations. One of the 4 patients developed grade III acute gut graft-versus-host disease. Immune reconstitution against CMV was detected in all 4 patients. Patients receiving CMV peptide-specific T cells and DC vaccination had peak immune reconstitution at least 10 days after the second DC vaccination. In summary, combining DC vaccine with T cell infusion appears feasible, although further study is required to ascertain its safety and efficacy in augmenting the effects of infusing donor-derived CMV-specific T cells.
Genetic Engineering of the Processing Site of D1 Precursor Protein of Photosystem II Reaction Center in Chlamydomonas reinhardtii (1996)

The D1 protein (D1) of photosystem II (PSII) reaction center is synthesized as a precursor (pD1) and then processed at its carboxyl terminus to establish the function of water cleavage. The amino acid sequence of the carboxyl terminal extension excised by this process is poorly conserved except for a residue after the cleavage site at position of 345. We have constructed a vector for site-directed mutagenesis of the chloroplast psbA gene encoding D1 of the green alga, Chlamydomonas reinhardtii. The vector enables one to transform the chloroplasts of a psbA deletion mutant (Fud7) and directly select transformants for resistance to spectinomycin. Using this transforming vector, we have substituted Ser345 to Gly, Cys, Val and Phe in order to investigate effects of the amino acid side chain at this position on the processing rate. All of the resulting transformants exhibited the PSII activity as wild type and grew normally under photoautotrophic conditions even under strong light where rapid turnover of D1 protein is expected to occur. Western blotting analysis demonstrated that mature D1 accumulates in these transformants at wild type level. Pulse and chase labeling of chloroplast-encoded proteins using [35S] sulfate revealed that the processing of D1 precursor protein occurs in all four transformants as efficiently as in wild type, at least under the experimental conditions examined. The results suggest that either the amino acid side chain at position of 345 (+1 position) is not crucial to the enzymatic cleavage of pD1 in vivo or the apparent rate of processing in vivo is not limited by the enzymatic cleavage.
Fusion of Multispectral and Panchromatic Images Using a Restoration-Based Method (2008)

Many remote-sensing satellites can obtain images in multispectral and panchromatic bands. By fusing low-resolution multispectral and high-resolution panchromatic images, one can obtain high-resolution multispectral images. In this paper, an image fusion algorithm based on image restoration is proposed to combine multispectral and panchromatic images. For remote-sensing satellites, the wavelength of the panchromatic band usually covers the wavelengths of the multispectral bands. This relationship between the two kinds of images is useful for fusion. In our approach, the low-resolution multispectral images are first resampled to the scale of the high-resolution panchromatic image. The relationship between these two kinds of images is then used to restore the resampled multispectral images. That is, the resampled multispectral images are modeled as the noisy blurred versions of the ideal multispectral images, and the high-resolution panchromatic image is modeled as a linear combination of the ideal multispectral images plus the observation noise. The ideal high-resolution multispectral images are then estimated based on the panchromatic and the resampled multispectral images. A closed-form solution of the fused images is derived here. Experiments show that the proposed fusion algorithm works effectively in integrating multispectral and panchromatic images.
An optimal shape encoding scheme using skeleton decomposition (2004)

This paper presents an operational rate-distortion (ORD) optimal approach for skeleton-based boundary encoding. The boundary information is first decomposed into skeleton and distance signals, by which a more efficient representation of the original boundary results. Curves of arbitrary order are utilized for approximating the skeleton and distance signals. For a given bit budget for a video frame, we solve the problem of choosing the number and location of the control points for all skeleton and distance signals and for all boundaries within a frame, so that the overall distortion is minimized. The problem is solved with the use of Lagrangian relaxation and a shortest path algorithm in a 4D directed acyclic graph (DAG) we propose. By defining a path selection pattern, we reduce the computational complexity of the 4D DAG shortest path algorithm from O(N/sup -5/) to O(N/sup -4/), where N is the number of admissible control points for a skeleton. A suboptimal solution is also presented for further reducing the computational complexity of the algorithm to O(N/sup -2/). The proposed algorithm outperforms experimentally other competing algorithms.
The effect of udder infection on the bacterial flora of the bulk milk of ten dairy herds (1984)

The significance of udder infection as a factor increasing the bacterial count of herd bulk milk was measured monthly for one year in ten dairy herds in Southern England. Staphylococcus aureus or mastitis streptococci were detected in 86% of samples, usually in numbers between 1000 and 10 000 c.f.u./ml of milk. However, in 8 and 2% of samples respectively greater than 20 000 or 100 000 c.f.u. of mastitis pathogens/ml of milk were detected. This occurred most commonly in the herds with a high incidence of Streptococcus uberis mastitis. The total bacterial counts of the herds' milks varied between 13 960 and 46 230 c.f.u./ml in the winter and between 6510 and 63 000 c.f.u./ml in the summer. No correlation was found between bacteriological quality of herd milk and the cleanliness of the milking machine and pipeline as assessed by plant rinses.
MONOENERGETIC 200FS (FWHM) ELECTRON BUNCH MEASUREMENT FROM THE LASER PLASMA CATHODE (2006)

A measurement of the electron bunch duration from a laser plasma cathode that can generate femtosecond electron bunches has been done. Since the time-resolution of the fastest streak camera is only 200 fs, we performed the spectrum measurement of coherent transition radiation (CTR) using an IR (infrared) bolometer with different filters and obtained the average spectrum. The bunch duration at 180 mm downstream from the plasma edge is 130±30 fs (FWHM) in a highmonoenergetic case and 250±70 fs (FWHM) in a lowmonoenergetic case. Since temporal elongation of highmonoenergetic electron bunch after 180 mm path is about 60 fs, the initial duration of the electron bunch is estimated to be 115 fs (FWHM).
Carbon-α-Fe2O3 Composite Active Material for High-Capacity Electrodes with High Mass Loading and Flat Current Collector for Quasi-Symmetric Supercapacitors (2022)

In this work, we report the synthesis of an active material for supercapacitors (SCs), namely α-Fe2O3/carbon composite (C-Fe2O3) made of elongated nanoparticles linearly connected into a worm-like morphology, by means of electrospinning followed by a calcination/carbonization process. The resulting active material powder can be directly processed in the form of slurry to produce SC electrodes with mass loadings higher than 1 mg cm−2 on practical flat current collectors, avoiding the need for bulky porous substrate, as often reported in the literature. In aqueous electrolyte (6 M KOH), the so-produced C-Fe2O3 electrodes display capacity as high as ~140 mAh g−1 at a scan rate of 2 mV s−1, while showing an optimal rate capability (capacity of 32.4 mAh g−1 at a scan rate of 400 mV s−1). Thanks to their poor catalytic activity towards water splitting reactions, the electrode can operate in a wide potential range (−1.6 V–0.3 V vs. Hg/HgO), enabling the realization of performant quasi-symmetric SCs based on electrodes with the same chemical composition (but different active material mass loadings), achieving energy density approaching 10 Wh kg−1 in aqueous electrolytes.
Single‐pedicled Fasciocutaneous Flap Survival In Aged Rat Model of Chronic Alcoholism (2015)

Impact of chronic ethanol consumption on signaling events underlying composite pedicled flap survival was examined in isocaloric pair-fed Sprague-Dawley rats that consumed Lieber-DeCarli '82 liquid 1000 kcal/L diet consisting of 15.1% protein, 35.9% fat and either 49% carbohydrates (control group) or 13.5% carbohydrates and 35.5% ethanol (alcoholic group). Six pairs of rats that were fed such diet for at least one year underwent surgery, where a 3:8 width to length ratio pedicled fasciocutaneous flap based on the inferior epigastric artery was raised in each rat and rotated into a defect created in the ventral surface. Tissue from the contralateral recipient site was snap-frozen to serve as baseline (day 0) for comparison with the flap harvested on 9th post-operative day. The endogenous expression of VEGF-A, FGF-2, IL-6, IL-10, TNFα, TIMP-1, MMP-9, Hsp47, NF-κB, cleaved Caspase-9, β-Actin, GAPDH and activating phosphorylation of Akt, STAT3, PLC-γ, eNOS, Src, FAK, p38 MAPK and ERK1/2 proteins were measured by Western Blotting in homogenates of proximal, middle and distal segments of the flaps to reflect the pro-angiogenic, inflammatory, anti-apoptotic, stress, motogenic and mitogenic cellular responses. The middle and distal segments were less prone to necrosis in control than in alcohol-fed animals that, in turn, expressed significantly lower levels of activated Akt, STAT3 and p-ERK. This data implies that chronic alcohol consumption leads to flap failure by impairing multiple signaling pathways whose cross-talk is essential for cell survival and expedient wound healing.
Iterative calculation of the transverse shear distribution in laminated composite beams (1996)

A smeared laminate beam model has been presented that can accurately predict the stress/strain distribution in general laminated beams, a capability that has not been previously possible with conventional smeared laminate beam models
The Work Management System (1991)

The author looks at a new computer support system, the Work Management System (WMS). The prime role of WMS is to automatically collect work from various sources, allocate that work to the required individual(s) and then despatch the work at the appropriate time such that: the right person with the right skill, information and stores will be available at the right place and time in a cost effective manner. The initial scope covers the repair and installation of basic telephone equipment for both residential and business customers, including payphones, and the internal activities related to maintaining network equipment.
Discriminating mental tasks using EEG represented by AR models (2002)

EEG signals are modeled using single-channel and multi-channel autoregressive (AR) techniques. The coefficients of these models are used to classify EEG data into one of two classes corresponding to the mental task the subjects are performing. A neural network is trained to perform the classification. When applying a trained network to test data, the authors find that the multivariate AR representation performs slightly better, resulting in an average classification accuracy of about 91%.
A versatile strategy for the synthesis of block copolymers bearing a photocleavable junction (2009)

Various block copolymers in which the blocks are held together by a photocleavable junction have been synthesized via a one-pot simultaneous ATRP–CuAAC “click” reaction process, and their easy photocleavage has been demonstrated.