gebhart/patrepeval huggingface dataset:
Effect of ion pairing on bond order and charge localization in alkyl phosphorothioates (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of ion pairing on bond order and charge localization in alkyl phosphorothioatesJanina. Baraniak and Perry A. FreyCite this: J. Am. Chem. Soc. 1988, 110, 12, 4059–4060Publication Date (Print):June 1, 1988Publication History Published online1 May 2002Published inissue 1 June 1988https://pubs.acs.org/doi/10.1021/ja00220a067https://doi.org/10.1021/ja00220a067research-articleACS PublicationsRequest reuse permissionsArticle Views155Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Dynamic parallelization and mapping of binary executables on hierarchical platforms (2006)

As performance improvements are being increasingly sought via coarse-grained parallelism, established expectations of continued sequential performance increases are not being met. Current trends in computing point towards platforms seeking performance improvements through various degrees of parallelism, with coarse-grained parallelism features becoming commonplace in even entry-level systems.Yet the broad variety of multiprocessor configurations that will be available that differ in the number of processing elements will make it difficult to statically create a single parallel version of a program that performs well on the whole range of such hardware. As a result, there will soon be a vast number of multiprocessor systems that are significantly under-utilized for lack of software that harnesses their power effectively. This problem is exacerbated by the growing inventory of legacy programs in binary executable form with possibly unreachable source code.We present a system that improves the performance of optimized sequential binaries through dynamic recompilation. Leveraging observations made at runtime, a thin software layer recompiles executing code compiled for a uniprocessor and generates parallelized and/or vectorized code segments that exploit available parallel resources. Among the techniques employed are control speculation, loop distribution across several threads, and automatic parallelization of recursive routines.Our solution is entirely software-based and can be ported to existing hardware platforms that have parallel processing capabilities. Our performance results are obtained on real hardware without using simulation.In preliminary benchmarks on only modestly parallel (2-way) hardware, our system already provides speedups of upto 40% on SpecCPU benchmarks, and near-optimal speedups on more obviously parallelizable benchmarks.
GaN-based ultraviolet light-emitting diodes with AuCl_3-doped graphene electrodes (2013)

We demonstrate AuCl3-doped graphene transparent conductive electrodes integrated in GaN-based ultraviolet (UV) light-emitting diodes (LEDs) with an emission peak of 363 nm. AuCl3 doping was accomplished by dipping the graphene electrodes in 5, 10 and 20 mM concentrations of AuCl3 solutions. The effects of AuCl3 doping on graphene electrodes were investigated by current-voltage characteristics, sheet resistance, scanning electron microscope, optical transmittance, micro-Raman scattering and electroluminescence images. The optical transmittance was decreased with increasing the AuCl3 concentrations. However, the forward currents of UV LEDs with p-doped (5, 10 and 20 mM of AuCl3 solutions) graphene transparent conductive electrodes at a forward bias of 8 V were increased by ~48, 63 and 73%, respectively, which can be attributed to the reduction of sheet resistance and the increase of work function of the graphene. The performance of UV LEDs was drastically improved by AuCl3 doping of graphene transparent conductive electrodes.
Analytical electron microscopy of advanced materials (1988)

Experiments are described and discussed, which make manifest the interaction between diffraction contrast information and compositional information obtained using analytical transmission electron microscopy. These two very different sorts of information are now available at resolutions controlled on the one hand by the imaging technique used, which can allow a resolution down to at best about 1 nm, and on the other by either the beam divergence or the minimum probe size at the electron exit side of the crystal, which can typically limit the spatial resolution to between 5 and 10 nm. Experimente werden beschrieben und diskutiert, die die Wechselwirkung zwischen Beugungskontrastinformationen und Zusammensetzungsinformationen, die mit analytischer Transmissions-elektronenmikroskopie erhalten werden, manifestieren. Diese beiden sehr unterschiedlichen Informationsarten stehen nun mit Auflösungen zur Verfügung, die auf der einen Seite durch die Abbildungstechnik, die im besten Fall eine Auflösung bis etwa 1 nm erlaubt, gesteuert werden und auf der anderen Seite entweder durch Strahldivergenz oder durch die minimalen Probenabmessungen an der Elektronenaustrittsseite des Kristalls, die die räumliche Auflösung auf Werte zwischen 5 und 10 nm begrenzen kann.
Semantic similarity based trust computation in websites (2007)

The World Wide Web has evolved at an extreme rate due to its capacity to provide an endless amount of information to the public users. Hence, the user finds himself lost in a pool of information, without knowing what to trust in order to retain. One could rely on the first website links displayed when renowned web search engines such as Google or Yahoo are invoked. However, are those initial displayed links really trustworthy because they came on top of the list? Can one trust specific information by the simple fact that it has been ranked high by virtue of being accessed frequently by other users? In this paper, we propose a method that overcomes the dependency of user.s feedback and allows one to dynamically compute the trust level of a website of a particular domain based on how semantically similar its content is with a trusted website of the same domain. The experimental results have been provided to demonstrate the utility of the proposed method.
Resistance to targeted therapies in acute myeloid leukemia (2022)

The introduction of new targeted therapies to the treatment algorithm of acute myeloid leukemia (AML) offers new opportunities, but also presents new challenges. Patients diagnosed with AML receiving targeted therapies as part of lower intensity regimens will relapse inevitably due to primary or secondary resistance mechanisms. In this review, we summarize the current knowledge on the main mechanisms of resistance to targeted therapies in AML. Resistance to FLT3 inhibitors is mainly mediated by on target mutations and dysregulation of downstream pathways. Switching the FLT3 inhibitor has a potential therapeutic benefit. During treatment with IDH inhibitors resistance can develop due to aberrant cell metabolism or secondary site IDH mutations. As a unique resistance mechanism the mutated IDH isotype may switch from IDH1 to IDH2 or vice versa. Resistance to gemtuzumab-ozogamicin is determined by the CD33 isotype and the degradation of the cytotoxin. The main mechanisms of resistance to venetoclax are the dysregulation of alternative pathways especially the upregulation of the BCL-2-analogues MCL-1 and BCL-XL or the induction of an aberrant cell metabolism. The introduction of therapies targeting immune processes will lead to new forms of therapy resistance. Knowing those mechanisms will help to develop strategies that can overcome resistance to treatment.
Reversing the Antilock Braking System Theory for Suture Removal (1987)

A simple and extremely practical technique for removal of long subcuticular sutures is possible by simply interposing a rubber band between the suture and the traction source. We have likened the technique in a reverse manner to the pulsing application of brakes in the antilock braking system now commonly found in modern automobiles. We also suggest with this paper that Prolene at this time be tried as the suture of choice in pullout repairs of all types.
Innovative dressing method for Mohs' surgery. (1996)

Mohs' surgery often requires multiple dressing changes in a single day. The innovative dressing method described here provides a reproducible, visually acceptable dressing with minimal damage to the patient's uninvolved skin. It also allows speedy removal and a smooth flow of events for the health care team.
2‐Substituierte 1‐Phenyl‐3‐sulfonamido‐3‐pyrazolin‐5‐one Über Pyrazole, 3. Mitteilung (1964)

Abstract Es werden zwei Synthesen der bisher unbekannten 2‐substituierten 1‐Phenyl‐3 sulfonamido‐3‐pyrazolin‐5‐one und dafür benötigte Zwischenprodukte beschrieben Die neuen Sulfonamide sind stark sauer und wirken am Meerschweinchen antiphlogistisch.
Effects of processing Kombu on lipid metabolism in genetically diabetes mice (2015)

遺伝性2型糖尿病マウス（KK/Ta）に軟化昆布を添加した高脂肪食を摂取させ，軟化昆布が糖尿病病態における脂質代謝に影響を及ぼすか検証することを目的として行った．KK/Ta マウスを3群に分け，高脂肪食に総食物繊維が5％になるようにセルロース（CO 群），乾燥昆布（IN 群），軟化昆布（SO 群）を添加した飼料を用いて68 日間飼育した．その結果，腹腔内脂肪組織重量はIN 群に比べてSO 群は有意に少なかった．血清コレステロール濃度はCO 群に比べて試験群は有意に低く，特にSO 群はIN 群と比べて増加が抑制されていた．本結果から，軟化昆布は糖尿病病態における脂質代謝異常を緩和することが示された．
Expression of an activated rasD gene changes cell fate decisions during Dictyostelium development. (1997)

It has been previously demonstrated that the expression of an activated rasD gene in wild-type Dictyostelium cells results in formation of aggregates with multitips, instead of the normal single tips, and a block in further development. In an attempt to better understand the role of activated RasD development, we examined cell-type-specific gene expression in a strain stably expressing high levels of RasD[G12T]. We found that the expression of prestalk cell-specific genes ecmA and tagB was markedly enhanced, whereas the expression of the prespore cell-specific gene cotC was reduced to very low levels. When the fate of cells in the multitipped aggregate was monitored with an ecmA/lacZ fusion, it appeared that most of the cells eventually adopted prestalk gene expression characteristics. When mixtures of the [G12T]rasD cells and Ax3 cells were induced to differentiate, chimeric pseudoplasmodia were not formed. Thus, although the [G12T]rasD transformant had a marked propensity to form prestalk cells, it could not supply the prestalk cell population when mixed with wild-type cells. Both stalk and spore cell formation occurred in low cell density monolayers of the [G12T]rasD strain, suggesting that at least part of the inhibition of stalk and spore formation during multicellular development involved inhibitory cell interactions within the cell mass. Models for the possible role of rasD in development are discussed.
An Efficient Method for the Preparation of Benzylic Bromides (2001)

Substituted benzylic compounds are brominated with an excess of N-bromosuccinimide (NBS) in CCl4 to the corresponding polybrominated mixtures which are then debrominated with diethyl phosphite and N,N-diisopropylethylamine to afford the desired monobromides in satisfactory yields and high purity.
AlleleCoder: a PERL script for coding co-dominant polymorphism data for PCA (2011)

A useful biological interpretation of diploid heterozygotes is in terms of the dose of the common allele (0, 1 or 2 copies). We have developed a PERL script that converts FASTA files into coded spreadsheets suitable for principal component analysis. In combination with R and R Commander, two- and three-dimensional plots can be generated for visualizing genetic relationships. Such plots are useful for characterizing plant genetic resources. This method nicely illustrated the spectrum of genetic diversity in tomato landraces and the varieties categorized according to human-mediated dispersal.
High-etch-rate low-bias bow outgassing BARC via-filling materials for 193-nm ArF lithographic process (2008)

As critical dimensions in integrated circuit (IC) device fabrication continue to shrink to less than 90 nm, designing multi-functional organic bottom anti-reflective coating (BARC) materials has become a challenge. In this paper, we report novel high performance BARC materials which are simultaneously capable of controlling reflectivity, planarizing on substrate surface, low bias filling without forming voids, low outgassing, high etch selectivity with resists and broad compatibility with resists. The new materials comprise of a chromophore that absorbs at 193 nm to give anti-reflective properties. By intriguing design of the crosslinking system to minimize the amount of low molecular weight additives and the by-product formation in the curing process, low-bias and low sublimation filling without formation of voids are achieved. In addition, the performance of the high etch rate BARC material can be further enhanced by blending with a low k high etch rate (~2.4X) material to achieve ultra high etch rate for ArF lithographic process. The filling properties, etch selectivity, lithographic and outgassing data of the new BARC materials will be presented.
Identification of UHRF2 as a novel DNA interstrand crosslink sensor protein (2018)

The Fanconi Anemia (FA) pathway is important for repairing interstrand crosslinks (ICLs) between the Watson-Crick strands of the DNA double helix. An initial and essential stage in the repair process is the detection of the ICL. Here, we report the identification of UHRF2, a paralogue of UHRF1, as an ICL sensor protein. UHRF2 is recruited to ICLs in the genome within seconds of their appearance. We show that UHRF2 cooperates with UHRF1, to ensure recruitment of FANCD2 to ICLs. A direct protein-protein interaction is formed between UHRF1 and UHRF2, and between either UHRF1 and UHRF2, and FANCD2. Importantly, we demonstrate that the essential monoubiquitination of FANCD2 is stimulated by UHRF1/UHRF2. The stimulation is mediating by a retention of FANCD2 on chromatin, allowing for its monoubiquitination by the FA core complex. Taken together, we uncover a mechanism of ICL sensing by UHRF2, leading to FANCD2 recruitment and retention at ICLs, in turn facilitating activation of FANCD2 by monoubiquitination.
Effects of Acute Clomipramine Administration on Syrian Hamster Circadian Rhythms (1998)

Drugs linked to the serotonergic system, like antidepressants, are able to modify the circadian system. The present experiments were designed to test whether clomipramine, a 5-HT reuptake inhibitor, was able to modify: a) the phase of free running activity rhythms; b) the light-induced phase shifts in Syrian hamsters. Clomipramine had a phase-dependent effect on the free running activity rhythm, with phase advances at CT 0-8 being significantly higher than at CT 8-16. Pretreatment with clomipramine inhibited phase advances in response to light pulses when applied at CT 19 while delays remained unaffected. The results suggest that acute clomipramine treatment can affect the expression of the circadian rhythmicity in Syrian hamsters.
Comparative study: Vonoprazan and proton pump inhibitors in Helicobacter pylori eradication therapy (2017)

Vonoprazan might be superior to PPIs in first-line <i>H. pylori</i> therapy, particularly for smokers. However, caution is required due to possible adverse events.
Control of hybrid AC/DC microgrid under islanding operational conditions (2014)

This paper presents control methods for hybrid AC/DC microgrid under islanding operation condition. The control schemes for AC sub-microgrid and DC sub-microgrid are investigated according to the power sharing requirement and operational reliability. In addition, the key control schemes of interlinking converter with DC-link capacitor or energy storage, which will devote to the proper power sharing between AC and DC sub-microgrids to maintain AC and DC side voltage stable, is reviewed. Combining the specific control methods developed for AC and DC sub-microgrids with interlinking converter, the whole hybrid AC/DC microgrid can manage the power flow transferred between sub-microgrids for improving on the operational quality and efficiency.
Indoles, Benzofurans, Phthalides, and Tolanes via Copper(I) Acetylides (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIndoles, Benzofurans, Phthalides, and Tolanes via Copper(I) AcetylidesC. E. Castro, E. J. Gaughan, and D. C. OwsleyCite this: J. Org. Chem. 1966, 31, 12, 4071–4078Publication Date (Print):December 1, 1966Publication History Published online1 May 2002Published inissue 1 December 1966https://pubs.acs.org/doi/10.1021/jo01350a045https://doi.org/10.1021/jo01350a045research-articleACS PublicationsRequest reuse permissionsArticle Views2395Altmetric-Citations310LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Evaluation of radio frequency immunity test facilities based on the scattered field of a conductive sphere (1996)

Abstract In the radiation immunity test for telecommunication equipment, an electromagnetic applicator such as chamber, a transmission electron microscopy (TEM) cell and a general transmission electron microscopy (GTEM) cell are used. Characteristics that include a semianechoic uniformity of the electromagnetic field without a device under test have been evaluated. However, characteristics that include an electromagnetic field in the presence of the device under test have not been reported. In this paper, it is recognized that these electroamgentic applicators are designed in such a way that they can generate an electromagnetic field simulating a plane wave. Based on the electric field distribution generated by the plane wave incident on a conducting sphere, the electric field is evaluated and compared in the case in which the device under test is placed within the applicator. Further, evaluation results are included for the size of the device under test for which the immunity test is possible in each applicator. The evaluation method first derives the theoretical value of the scattered electric field when a plane wave is incident on the conducting sphere in free space. Next, these theoretical values are compared with the measured electric field values around the conducting sphere in each electromagnetic applicator. It was found that the difference between the measured and the theoretical results is the smallest and the frequency dependence is the lowest in a semianechoic chamber. In the case of a TEM cell and a GTEM cell, it was found that the difference between the measured and the theoretical values is less than +6 dB if the magnitude of the device under test is less than one‐third the spacing between the inner and outer conductors.
Preparation, properties and application of sapphire single-crystal fibers grown by the EFG method (2013)

Sapphire – the single crystal of aluminum oxide (Al2O3) – is one of the most important artificially produced materials. The sapphire fibres studied were grown in Crytur using the “edge-defined film-fed growth” (EFG) technique. Their unique physical and chemical properties can be employed in various applications. Due to their high refractive index and a broad transmission band spanning the ultraviolet, visible and infrared bands, sapphire fibres are perfect waveguides in harsh environments. The current major applications are Er:YAG laser beam delivery and pyrometric and spectrometric measurements in furnaces, combustion engines, etc. In this paper we summarize an adjustment of the EFG method to grow thin filaments by giving possible molybdenum die designs. We investigated the fibres using an optical microscope and measured their transmission of an Er:YAG laser beam (2.94 μm). The attenuation of the tested samples is approximately 0.1 dB/cm.
Korean frailty and aging cohort study (KFACS): cohort profile (2020)

The KFACS plans to identify outcomes and risk factors associated with frailty by conducting a 10-year cohort study, with a follow-up every 2 years, using 3014 baseline participants.
Patient-Reported Factors Associated with the Onset of Hyperfunctional Voice Disorders (2020)

The results support the general clinical view that PVH is most strongly related to the gradual accumulated effects of phonotrauma, while NPVH has a more heterogeneous etiology. The identified PVH and NPVH subgroups may have clinical relevance and future work could investigate differences in treatment and outcomes among these subgroups.
Electron Transfer by Copper Centers (2004)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectron Transfer by Copper CentersDavid B. RorabacherView Author Information Department of Chemistry, Wayne State University, Detroit, Michigan 48202 Cite this: Chem. Rev. 2004, 104, 2, 651–698Publication Date (Web):January 22, 2004Publication History Received17 April 2003Published online22 January 2004Published inissue 1 February 2004https://pubs.acs.org/doi/10.1021/cr020630ehttps://doi.org/10.1021/cr020630eresearch-articleACS PublicationsCopyright © 2004 American Chemical SocietyRequest reuse permissionsArticle Views5914Altmetric-Citations390LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Kinetic parameters,Kinetics,Ligands,Redox reactions,Transfer reactions Get e-Alerts