gebhart/patrepeval huggingface dataset:
A stable, engineered TL1A ligand co-stimulates T cells via specific binding to DR3 (2022)

TL1A (TNFSF15) is a TNF superfamily ligand which can bind the TNFRSF member death receptor 3 (DR3) on T cells and the soluble decoy receptor DcR3. Engagement of DR3 on CD4+ or CD8+ effector T cells by TL1A induces downstream signaling, leading to proliferation and an increase in secretion of inflammatory cytokines. We designed a stable recombinant TL1A molecule that (1) displays high monodispersity and stability, (2) displays the ability to activate T cells in vitro and in vivo, and (3) lacks binding to DcR3 while retaining functional activity via DR3. Together these results suggest the TL1A ligand can be amenable to therapeutic development on its own or paired with a tumor-targeting moiety.
Studies on nonpyridinoid azaaromatic systems. 7. Synthesis and tautomeric character of cyclopenta[c]quinoline (benzo[c][2]pyrindine) (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies on nonpyridinoid azaaromatic systems. 7. Synthesis and tautomeric character of cyclopenta[c]quinoline (benzo[c][2]pyrindine)John J. Eisch, Harsh Gopal, and Chili Tang KuoCite this: J. Org. Chem. 1978, 43, 11, 2190–2196Publication Date (Print):May 1, 1978Publication History Published online1 May 2002Published inissue 1 May 1978https://pubs.acs.org/doi/10.1021/jo00405a023https://doi.org/10.1021/jo00405a023research-articleACS PublicationsRequest reuse permissionsArticle Views260Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Just Fun or Fundamental? Fathers’ Narratives of Leisure with Their Children with Autism Spectrum Disorder (2017)

Anchored in the generative fathering framework and critical disability studies (CDS), I used a narrative approach to study 11 fathers’ stories of leisure with their children with autism spectrum disorder (ASD) to highlight how leisure activities are given meaning and constructed as part of active fathering. I produced four narratives - narratives of action, narratives of adjustment, narratives of tension and narratives of relationships that captured fathers’ experiences of leisure with their children with ASD. Narratives of action are the stories of what fathers are doing in their day- to- day interactions with their children. Narratives of adjustment depict how fathers have shifted and re-defined expectations of their children and themselves following their children’s diagnosis of ASD. Narratives of tension capture fathers’ strain in concurrently having to acquiesce and advocate against financial, environmental and societal constraints. Lastly, in narratives of relationships, fathers illustrate the relational outcomes of their involvement with their children, including an appreciation of their children’s individuality and the father-child connection. The findings augment a deeper understanding of fathering children with ASD and the father-child relationship. By understanding fathers’ perceived successes and challenges in leisure activities in the home and community settings, service providers can better engage and support fathers in home- and community-based leisure.
Ventricular arrhythmia detection using time-domain template algorithms (2002)

Implantable cardioverter defibrillators (ICDs) have shown success in reliably terminating potentially fatal arrhythmias, i.e. ventricular tachycardia (VT) and ventricular fibrillation (VF), by delivering electrical therapy to restore normal sinus rhythm. However, the ICD often applies defibrillation to VT instead of employing specialized lower energy therapies. In this study, variability (standard deviation and interquartile range) of four proposed algorithms was tested to determine their capacity to discriminate VT from VF. Algorithms included correlation waveform analysis, bin area method, normalized difference of area method, and derivative area method. Multiple thresholds were tested and relative operating characteristic curves compared parameters and algorithms. Results indicated that these methods were able to distinguish between VT and VF in most patients. However, due to loss of VF sensitivity, the algorithms in their current form are not recommended for implementation in commercial devices.
Burbujas e inestabilidad : el estado de la cuestión (2004)

El tema de las burbujas, esto es, la incidencia sobre la economía de las variaciones excesivas en la valoración de los activos y las consecuencias de su eventual corrección violenta, a parece con mucha frecuencia en la literatura reciente. En el presente trabajo se pretende plantear el estado de la cuestión con tres objetivos: Sintetizar las ideas fundamentales que han prevalecido de las principales experiencias de sobrevaloración de activos, exponer los principales puntos en los que existe acuerdo respecto al fenómeno de las burbujas y situar el papel de los bancos centrales dentro de este panorama. Bubbles, that is, the impact on economy of excessive variations in the valuation of assets and the consequences of its possible violent correction, represent a very common subject matter in the recent literature. In this working paper, we will try to set out the state of play with three objectives: To summarize the main prevailing ideas of the most important experiences of overvaluation of assets, to set out the main points of agreement regarding the bubbles phenomenon, and to give central banks their place within this scene.
Sexual dimorphism and sexual selection in cytheroidean ostracodes from the Late Cretaceous of the U.S. Coastal Plain (2017)

Abstract Sexual dimorphism is common in many extant animals, but it is difficult to demonstrate in fossil species. Working with material from the Late Cretaceous of the U.S. Coastal Plain, we herein analyze sexual dimorphism in ostracodes from the superfamily Cytheroidea, a group whose extant members have males that are relatively more elongate than females. We digitized outlines of more than 6000 individual ostracode valves or carapaces, extracted size (area) and shape (length-to-height ratio) information, and used finite mixture models to assess hypotheses of sexual dimorphism. Male and female clusters can be discerned in nearly all populations with sufficient data, resulting in estimates of size and shape dimorphism for 142 populations across 106 species; an additional nine samples are interpreted to consist only of females. Dimorphism patterns varied across taxa, especially for body size: males range from 30% larger to 20% smaller than females. Magnitudes of sexual dimorphism are generally stable within species across time and space; we can demonstrate substantial evolutionary changes in dimorphism in only one species, Haplocytheridea renfroensis . Several lines of evidence indicate that patterns of sexual dimorphism in these ostracodes reflect male investment in reproduction, suggesting that this study system has the potential to capture variation in sexual selection through the fossil record.
<p>Brolucizumab: evidence to date in the treatment of neovascular age-related macular degeneration</p> (2019)

Age-related macular degeneration (AMD) is a global health concern and the leading cause of vision loss in the developed world. Intravitreal anti-vascular endothelial growth factor (VEGF) therapy has revolutionized the treatment of neovascular AMD, but there are still challenges with delivery of care and treatment burden with currently available medications. Brolucizumab is a single-chain antibody fragment inhibitor of all isoforms of VEGF-A. Its small molecular weight allows for high solubility and tissue penetration. Brolucizumab has most recently been evaluated in 2 parallel phase 3 randomized controlled trials which demonstrated its safety and efficacy in an extended dosing regimen. The present review summarizes the safety, visual and anatomic outcomes, and durability of brolucizumab in the treatment of neovascular AMD and discusses some of the extended dosing regimens explored with currently approved medications and other therapies still under clinical investigation.
Design of L and X band class E power amplifiers with GaAs pHEMT technology for space SAR (2011)

The paper describes the design of class E power amplifiers for SAR space applications, exploiting a 0.35-um pHEMT GaAs process. An L-band 10-Watt push-pull hybrid amplifier has been designed and implemented. The HPA features 73% PAE and 81% drain efficiency at 1.275 GHz. The performances of the class E HPA are also compared with a class AB HPA, exploiting the same technology. Class E design was also evaluated at X band, which for this technology is beyond the limit for the devices' class E operation capability. Two different prototype amplifiers were designed exploiting different device periphery. The single-cell amplifier delivers about 31 dBm output power with 64% peak PAE, whereas the double-cell circuit features 27 dBm output power with 70% peak PAE. These prototype amplifiers prove the possibility to use this process for the design of X band MMIC HPA for SAR space applications operating with high efficiency.
Comparative therapeutic efficacy of teicoplanin and vancomycin in normal and in neutropenic mice infected with Staphylococcus haemolyticus (1991)

This study describes the evaluation of a murine bacteraemia model for assessing antibiotic efficacy in normal and neutropenic mice infected with coagulase-negative staphylococci. In one such evaluation, it was found that there was no significant (P greater than 0.05) difference in the ability of teicoplanin or vancomycin to protect normal or neutropenic CD-1 mice, lethally-infected with Staphylococcus haemolyticus. However, about a four-fold increase of either antibiotic was needed to protect the immunocompromised animals.
More than mere coloring: The art of spectral vision (1992)

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Extracting Social Networks from Literary Fiction (2010)

We present a method for extracting social networks from literature, namely, nineteenth-century British novels and serials. We derive the networks from dialogue interactions, and thus our method depends on the ability to determine when two characters are in conversation. Our approach involves character name chunking, quoted speech attribution and conversation detection given the set of quotes. We extract features from the social networks and examine their correlation with one another, as well as with metadata such as the novel’s setting. Our results provide evidence that the majority of novels in this time period do not ﬁt two characterizations provided by literacy scholars. Instead, our results suggest an alternative explanation for differences in social networks.
Digital Photonic Production of Micro Structures in Glass by In-Volume Selective Laser-Induced Etching using a High Speed Micro Scanner (2012)

Digital photonic production of 3D microfluidic devices and assembled micro mechanics inside fused silica glass is carried out using ISLE directly from digital CAD data. To exploit the potential productivity of new high average power fs-lasers >150 W a modular high speed scanning system has been developed. Acousto-optical beam deflection, galvo-scanners and translation stages are controlled by CAM software. Using a lens with 10 mm focal length a focus radius of 1 μm is scanned with a velocity of 12 m/s on 400 μm track radius enabling the up-scaling of the ISLE- process using fs-laser radiation with up to 30 W.
Study of novel traction substation hybrid power quality compensator (2003)

In order to improve the power quality of the traction power supply system, a novel hybrid power quality compensator with new construction and new compensation method is proposed. The hybrid power quality compensator has the following features: (1) a three-phase voltage type converter is used in two-phase circuit of the traction power supply systems. The power quality of traction substation can be regulated integrally because the two feeders are linked indirectly; (2) through a Scott transformer, two banks of passive filters and the three-phase converter are connected in series so that the capacity of the converter is reduced greatly; (3) the compensating object is not one of the feeders but the traction substation itself; and (4) by regulating the active power currents in two feeders, the traction substation will reach a load balance status. So the reactive power, negative-sequence and harmonic currents in two feeders of a traction substation are canceled together. Its feasibility is proven by simulation results.
ASRI2005‐88  Comparable levels of CD4+CD25+ CTLA4+ Treg cells in peripheral blood of pre‐eclampsia and normal pregnant patients (2005)

The acceptance of the semiallogeneic fetus within the maternal environment requires tolerance mechanisms not fully characterized yet. Normal pregnancy is known to be associated with a Th2 profile. Furthermore, T‐regulatory cells were proposed to regulate the Th2/Th1 balance at early stages of pregnancy. Treg may avoid the shift to a Th1 profile preventing miscarriage. Accordingly, spontaneous abortion is characterized by a Th1 dominance and diminished levels of Tregulatory cells (Treg). The major aim of the present work was to investigate if pre‐eclampsia, a late immunological complication of pregnancy, is characterized by similar hallmarks. Therefore, we measured the surface antigens CD4, CD25, CD8, CTLA4 (as well as the secretion of IL‐10) in peripheral blood from patients suffering from pre‐eclampsia (n = 8) and age‐matched patients undergoing normal pregnancies (n = 9) by 4‐colour flow‐cytometry. We were not able to find any significant differences in the levels of CD4 + , CD25 + , CD8 + , CTLA4, CD4 + /CD25 + , CD4 + /CD25 bright , CD4 + /CTLA4, CD25 + /CTLA4, CD4 + /CD25 + /CTLA4, CD8 + /CD25 + , CD8 + /CTLA4 or CD8 + /CD25 + /CTLA4 cell subsets. Our data suggest that Treg may not participate in the onset of pre‐eclampsia and suggest other regulatory mechanisms during late pregnancy.
Transient thermal-lensing effects on the performance of repetitively pulsed solid-state lasers (1992)

A computational model was developed to predict solid-state laser performance in the start-up transient regime of a repetitive pulse operation. Laser output in this regime is sensitive to the interaction of rate-equation, thermal-transport, and beam-propagation effects. A high-repetition-rate operation produces pulse trains that decay at a rate determined by the competition between energy deposition in the rod and surface cooling. Selected pulses in a train turn on and off as the repetition rate is increased because of the varying residual population inversion between pulses.
A highly stretchable double-network composite (2016)

Inspired by the toughening mechanism of double-network (DN) hydrogels, a soft composite consisting of a fabric mesh and VHB tape layers was fabricated. The composite was as stiff as the fabric mesh, and as stretchable as the VHB tape. At certain compositions, the composite was significantly stronger and tougher than the base materials. The extensibility and toughness of the composite can be attributed to a damage delocalization mechanism similar to that of the DN gels. In the partially damaged regions, the fabric mesh fragmented into small islands, surrounded by the highly stretched VHB tapes. Accommodated by the finite sliding at the interface, the large deformation of the composite is highly non-affine. Just as the DN gels, the coexistence of the partially damaged and intact regions resulted in a stable necking in the composite when subjected to uniaxial tension. The propagation of the necking zone corresponded to a plateau on the stress-stretch curve. During cyclic loading, the composite also exhibited stress hysteresis with almost recoverable strain, similar to that in a DN gel. To rationalize these observations and to better understand the underlying physical mechanism, a simple 1D model has been developed for the damage evolution process in the composite. The predictions of the model have achieved good agreement with the measured properties of the composite of various compositions. Furthermore, the composite itself may also be regarded as a macroscopic model when studying the properties and toughening mechanism of the DN gels.
Unity 3.x Game Development Essentials (2011)

This book follows an informal, demystifying approach to the world of game development with the Unity game engine. With no prior knowledge of game development or 3D required, you will learn from scratch, taking each concept at a time working up to a full 3D mini-game. You'll learn scripting with C# or JavaScript and master the Unity development environment with easy-to-follow stepwise tasks. If you're a designer or animator who wishes to take their first steps into game development or prototyping, or if you've simply spent many hours sitting in front of video games, with ideas bubbling away in the back of your mind, Unity and this book should be your starting point. No prior knowledge of game production is required, inviting you to simply bring with you a passion for making great games.
Observation ofY(3940)→J/ψωinB→J/ψωKatBABAR (2008)

We present a study of the decays B;{0,+}-->J/psiomegaK;{0,+} using 383x10;{6} BB[over ] events obtained with the BABAR detector at PEP-II. We observe Y(3940)-->J/psiomega, with mass 3914.6_{-3.4};{+3.8}(stat)+/-2.0(syst) MeV/c;{2}, and width 34_{-8};{+12}(stat)+/-5(syst) MeV. The ratio of B0 and B+ decay to YK is 0.27_{-0.23};{+0.28}(stat)-0.01+0.04(syst), and the relevant B0 and B+ branching fractions are reported.
The Authentication Suboption for the Dynamic Host Configuration Protocol (DHCP) Relay Agent Option (2005)

The Dynamic Host Configuration Protocol (DHCP) Relay Agent Information
Option (RFC 3046) conveys information between a DHCP Relay Agent and a
DHCP server. This specification defines an authentication suboption
for that option, containing a keyed hash in its payload. The suboption
supports data integrity and replay protection for relayed DHCP
messages. [STANDARDS-TRACK]
J2EE development frameworks (2005)

Java 2 Enterprise Edition has excelled at standardizing many important middleware concepts. For example, J2EE provides a standard interface for distributed transaction management, directory services, and messaging. In addition, Java 2 Standard Edition (J2SE), which underpins J2EE, provides a largely successful standard for Java interaction with relational databases. However, the platform has failed to deliver a satisfactory application programming model. Many in the open source community, especially smaller vendors, have chosen the alternative of developing frameworks designed to simplify the experience of building J2EE applications. Popular frameworks such as Struts, Hibernate, and the Spring Framework play an important role in many of today's J2EE development projects.
Anisotropic mechanical properties in the healthy human brain estimated with multi-excitation transversely isotropic MR elastography (2022)

Magnetic resonance elastography (MRE) is an MRI technique for imaging the mechanical properties of brain in vivo, and has shown differences in properties between neuroanatomical regions and sensitivity to aging, neurological disorders, and normal brain function. Past MRE studies investigating these properties have typically assumed the brain is mechanically isotropic, though the aligned fibers of white matter suggest an anisotropic material model should be considered for more accurate parameter estimation. Here we used a transversely isotropic, nonlinear inversion algorithm (TI-NLI) and multiexcitation MRE to estimate the anisotropic material parameters of individual white matter tracts in healthy young adults. We found significant differences between individual tracts for three recovered anisotropic parameters: substrate shear stiffness, <i>μ</i> (range: 2.57 - 3.02 kPa), shear anisotropy, <i>ϕ</i> (range: -0.026 - 0.164), and tensile anisotropy, <i>ζ</i> (range: 0.559 - 1.049). Additionally, we demonstrated the repeatability of these parameter estimates in terms of lower variability of repeated measures in a single subject relative to variability in our sample population. Further, we observed significant differences in anisotropic mechanical properties between segments of the corpus callosum (genu, body, and splenium), which is expected based on differences in axonal microstructure. This study shows the ability of MRE with TI-NLI to estimate anisotropic mechanical properties of white matter and presents reference properties for tracts throughout the healthy brain.
Accurate Design of Fracturing Treatment Requires Conductivity Measurements at Simulated Reservoir Conditions (1988)

ABSTRACT Recent fracture conductivity testing in the laboratory has achieved a new degree of realistic simulation of reservoir fracture conditions. Many investigators are now attempting to develop more accurate testing procedures. At least two laboratories have published data where conductivity tests have simultaneously included the effects of gel filter cakes, formation core effects, and extended test times at representative reservoir stress and temperatures. In this paper, work published in 1986 and 1987 is reviewed, and additional conductivity data with gel filter cakes are presented. Data showing the result of varying the proppant concentration inside the fracture from 0.75 up to 2.8 lb/ft2 are presented for the first time, showing that the effect of proppant concentration can not be neglected. The economic success of hydraulic fracturing treatments depend on obtaining sufficient fracture conductivity within the proppant bed. This is illustrated by using a fracture design simulator to model the resultant propped fracture geometry and proppant distribution. By incorporating laboratory measured conductivity values (where gel filter cakes are present) these simulations show the importance of having realistic conductivity data when trying to optimize the treatment design.
Enhanced tunnel magnetoresistance in a spinel oxide barrier with cation-site disorder (2012)

We report enhanced tunnel magnetoresistance (TMR) ratios of 188$%$ (308$%$) at room temperature and 328$%$ (479$%$) at 15 K for cation-site-disordered MgAl${}_{2}$O${}_{4}$-barrier magnetic tunnel junctions (MTJs) with Fe (Fe${}_{0.5}$Co${}_{0.5}$ alloy) electrodes, which exceed the TMR ratios theoretically calculated and experimentally observed for ordered spinel barriers. The enhancement of TMR ratios is attributed to the suppression of the so-called band-folding effect in ordered spinel MTJs [Phys. Rev. B 86, 024426 (2012)]. First-principles calculations describe a dominant role of the oxygen sublattice for spin-dependent coherent tunneling, suggesting a mechanism of coherent tunneling occurring even in the disordered systems.