gebhart/patrepeval huggingface dataset:
Adsorption of iii/v ions (In(iii), Ga(iii) and As(v)) onto SiO2, CeO2 and Al2O3 nanoparticles used in the semiconductor industry (2016)

The semiconductor industry annually uses thousands of tons of nanoparticles (NPs) in chemical mechanical polishing (CMP) processes.
The increasing isolation ofSerratiaspecies from clinical specimens (1979)

A 14-month survey was undertaken in a diagnostic bacteriology laboratory to determine the incidence of Serratia spp. in routine clinical specimens. Gram-negative organisms with enterobacteria-like colonies were tested by a simple screening procedure. Fifty-eight strains of S. marcescens and two strains of S. liquefaciens were isolated from 59 patients. The strains were usually non-pigmented and exhibited multiple antibiotic resistance. Serotyping and determination of bacteriocine sensitivity patterns revealed that the majority of infections were sporadic, although episodes of cross-infection did occur. S. marcescens was considered to contribute significantly to morbidity and mortality in 53% of patients and appears to be of increasing importance in hospital-acquired infections.
Construction and Performance Studies of Large Resistive Micromegas Quadruplets (2018)

In view of the use of Micromegas detectors for the upgrade of the ATLAS muon system, two detector quadruplets with an area of 0.3 m 2 per plane serving as prototypes for future ATLAS chambers have been constructed. They are based on the resistive-strip technology and thus spark tolerant. The detectors were built in a modular way. The quadruplets consist of two double-sided readout panels and three support (or drift) panels equipped with the micromesh and the drift electrode. The panels are bolted together such that the detector can be opened and cleaned, if required. Two of the readout planes are equipped with readout strips inclined by 1.5 degree. In this talk, we present the results of detailed performance studies based on X-Ray and cosmic ray measurements as well as measurements with 855 MeV electrons at the MAMI accelerator. In particular, results on reconstruction efficiencies, track resolution and gain homogeneity is presented.
Anterior Scleral Buckling Procedure for Cyclodialysis Cleft With Chronic Hypotony (2006)

Cyclodialysis clefts occur when the attachment of the ciliary body to the scleral spur is disrupted. The mechanism is usually traumatic or iatrogenic after phacoemulsification or other intraocular manipulation. Treatment becomes necessary when hypotony occurs, with maculopathy being the most visually significant sequela. A patient who failed conventional treatment for hypotony and eventually benefited from a novel surgery to correct his cyclodialysis cleft is described.
REVERSIBLE DEFICIENCY OF INTACT THROMBOSPONDIN AND MEMBRANE GLYCOPROTEIN Ia IN PLATELETS OF A PATIENT WITH A BLEEDING DISORDER (1987)

A 52 year old female patient with a severe bleeding tendency since the age of two was studied. Her history revealed recurrent petechial bleedings, two severe postoperative haemorrhagic episodes and intensivemenstrual bleedings which required blood transfusions. Coagulation studies ruled out any coagulation disorder including von Willebrand's disease. Platelet count and morphology(using light and electron microscopy) were normal. The patient had prolonged bleeding times (up to 15 min). Her platelets aggregated normally in response to ADP, arachidonic acid, thrombin, ionophore A 23187, epinephrine and ristocetin. In contrast, platelet aggregation in the presence of collagen and wheat germ agglutinin could only be achieved with very high doses of these agonists. Repeated analyses of the patient's platelet proteins by two-dimensional 0'Farrel gel electrophoresis followed by silver staining or blotting onto nitrocellulose and staining with a mixture of peroxidase-coupled lectins showed that glycoprotein la and intact thrombospondin were absent. An immunoblot for thrombospondin showed several proteins with lower molecular weight than thrombospondin. Preincubation of the patient's platelets with thrombospondin normalized collagen-induced aggregation.At a recent follow-up examination the patient had no petechial bleedings. Platelet protein analysis revealed thatintact thrombospondin and glycoprotein la were present. These results suggest that both glycoprotein la and thrombospondin have essential roles in collagen-induced platelet aggregation.
Room temperature, continuous wave lasing in microcylinder and microring quantum dot laser diodes (2012)

We demonstrate room temperature, continuous wave lasing of laser diodes based on AlGaAs whispering gallery mode (WGM) resonators (microcylinder and microring) embedding a quantum dot (QD) active layer. Using InGaAlAs QDs, high-Q (&amp;gt;60 000) lasing modes are observed around 910 nm, up to 50 °C. Lasing with similar performance is obtained around 1230 nm, using InAs QDs. Furthermore, we show that the current injection in the active part of the device is improved in ring resonators, leading to threshold currents of approximately 4 mA for a device with 80 μm diameter. This geometry also suppresses WGMs with a high radial order, thus simplifying the lasing spectra. In these conditions, stable single-mode and two-color lasing can be obtained.
A sparse bayesian approach to multistatic radar imaging (2011)

We tackle the problem of multistatic radar image formation by simultaneously exploiting the sparsity and covariance structure of radar images measured by a local GSM distribution of wavelet coefficients. Our aim is to gauge the extent to which such local statistical information can be leveraged in addition to the commonly used l <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> sparsity constraint. Though we assume knowledge of the covariance structure of the source image, this provides a benchmark for subsequent relaxation of this assumption and its generalization to more complex probabilistic models of scene structure.
The design and fabrication of two portal vein flow phantoms by different methods (2014)

The fabrication methods and materials employed for the study yielded durable portal vein phantoms.
Detection of chicken anaemia virus by DNA hybridization and polymerase chain reaction (1992)

A clone containing the complete genome of chicken anaemia virus (CAV) was used in hybridizations with DNA from various field isolates of CAV. CAV DNA from all field isolates was detected in a polymerase chain reaction with oligonucleotides derived from the sequence of the cloned CAV DNA as primers. By way of Southern blot analysis with (32)P-labelled DNA probes derived from cloned CAV DNA, all field isolates were shown to contain DNA molecules of about 2.3 kb, i.e. the size of cloned CAV DNA. In a dot-blot assay it was demonstrated that non-radioactively-labelled cloned CAV DNA hybridized specifically to DNA from field isolates. The cloned CAV DNA is highly similar to the DNA of field isolates, as borne out by restriction-enzyme mapping. We conclude that our cloned CAV genome is representative for CAV in the field. The described PCR and hybridization techniques, may, therefore, be used for research and diagnosis of CAV infections.
Dopamine targets cycling B cells independent of receptors/transporter for oxidative attack: Implications for non-Hodgkin’s lymphoma (2006)

Human B lymphocytes and derived lines from a spectrum of B cell malignancy were studied for expression of dopaminergic pathway components and for their cytostatic response to the catecholamine and related, potentially therapeutic compounds. Proliferating normal lymphocytes and dividing malignant clones rapidly arrested on exposure to dopamine in the low (</=10 muM) micromolar range. The antiparkinsonian drugs l-DOPA and apomorphine (particularly) were similarly antiproliferative. With the exception of D4, dopamine receptors D1-D5 were variably expressed among normal and neoplastic B cell populations, as was the dopamine transporter. Transcripts for D1 and D2 were frequently found, whereas D3 and D5 revealed restricted expression; dopamine transporter was detected in most cases. Nevertheless, pharmacological analysis disclosed that dopamine targeted cycling B cells independent of these structures. Rather, oxidative stress constituted the primary mechanism: the catecholamine's actions being mimicked by hydrogen peroxide and reversed by exogenous catalase, and evidence for the intracellular redox protein thioredoxin contributing protection. Among proliferating clones, growth arrest was accompanied by cell death in populations deplete in antiapoptotic Bcl-2: resting lymphocytes escaping low micromolar dopamine toxicity. Dysregulated bcl-2 expression, although preventing oxidative-induced caspase-dependent apoptosis, by itself conferred only minor protection against dopamine cytostasis. The selective impact of dopamine on lymphocytes that are in active cycle indicates an axis for therapeutic intervention not only in B cell neoplasia but also in lymphoproliferative disturbances generally. Rational tailoring of drug delivery systems already in development for Parkinson's disease could provide ideal vehicles for carrying the oxidative hit directly to the target populations.
Verrous numériques sur internet (2007)

info:eu-repo/semantics/published
Integrated PiezoMEMS actuators and sensors (2010)

The ability to combine both actuation and sensing technologies into one unified MEMS fabrication process is enabling for a wide variety of applications including high frequency filters, transformers and mm-scale robotics. This research demonstrates piezoelectric MEMS (PiezoMEMS) devices based on lead zirconate titanate (PZT) thin films including switchable resonators, transformers, and microflight actuators with integrated strain sensors. PiezoMEMS resonators and transformers combine actuation and sensing on a single device platform. Current research on PZT based resonators is focused on optimizing the performance for both high quality factor, Q, and low motional resistance. Resonators in the low tens of MHz can also be utilized as piezoelectric resonant transformers and are predicted to achieve AC/DC gains in the range of 2 to 8. In addition, strain sensors positioned at the cantilever root of PiezoMEMS microflight actuators provide direct feedback of the motional response of the actuated wing.
A simple design method of reflection-suppressed photonic crystal cavity with asymmetric waveguides (2016)

A simple and versatile design method for suppressing the reflection of photonic crystal (PC) cavities is proposed. The proposed method only requires the tuning of the waveguide width and distance between the waveguide and cavity, without changing the structure of cavity itself.
Hybrid Technique for Coherent Raman Spectroscopy (2007)

We develop a hybrid technique for coherent Raman spectroscopy, and apply it to pyridine. The comparison with spontaneous Raman measurements shows 105-fold increase in Raman-scattering efficiency and provides an estimate for the excited coherence (~0.5×10-3).
Hetaryl- and heteroarylvinyl-substituted nitrofurans identified as non-cytotoxic selective antitubercular agents (2022)

New (E)-5-[2-(5-nitrofuran-2-yl)vinyl]-1,2,4-oxadiazoles and 5-(5-nitrofuran-2-yl)-1,2,4-oxadiazoles were synthesized via the base-promoted condensation of nitrofuran-containing acyl chlorides with amidoximes. Testing these compounds against Gram-negative E. coli, Gram-positive B. subtilis and S. aureus as well as M. tuberculosis HRv37 strain revealed three compounds being selectively antimycobacterial. None of these compounds displayed any cytotoxicity towards human pancreatic epithelioid carcinoma cell line, PANC-1.
Machine learning enables discovery of DNA-carbon nanotube sensors for serotonin (2021)

Abstract DNA-wrapped single walled carbon nanotube (SWNT) conjugates have remarkable optical properties leading to their use in biosensing and imaging applications. A critical limitation in the development of DNA-SWNT sensors is the current inability to predict unique DNA sequences that confer a strong analyte-specific optical response to these sensors. Here, near-infrared (nIR) fluorescence response datasets for ~100 DNA-SWNT conjugates, narrowed down by a selective evolution protocol starting from a pool of ~10 10 unique DNA-SWNT candidates, are used to train machine learning (ML) models to predict new unique DNA sequences with strong optical response to neurotransmitter serotonin. First, classifier models based on convolutional neural networks (CNN) are trained on sequence features to classify DNA ligands as either high response or low response to serotonin. Second, support vector machine (SVM) regression models are trained to predict relative optical response values for DNA sequences. Finally, we demonstrate with validation experiments that integrating the predictions of ensembles of the highest quality CNN classifiers and SVM regression models leads to the best predictions of both high and low response sequences. With our ML approaches, we discovered five new DNA-SWNT sensors with higher fluorescence intensity response to serotonin than obtained previously. Overall, the explored ML approaches introduce an important new tool to predict useful DNA sequences, which can be used for discovery of new DNA-based sensors and nanobiotechnologies.
Learning to Recommend Accurate and Diverse Items (2017)

In this study, we investigate diversified recommendation problem by supervised learning, seeking significant improvement in diversity while maintaining accuracy. In particular, we regard each user as a training instance, and heuristically choose a subset of accurate and diverse items as ground-truth for each user. We then represent each user or item as a vector resulted from the factorization of the user-item rating matrix. In our paper, we try to discover a factorization for matching the following supervised learning task. In doing this, we define two coupled optimization problems, parameterized matrix factorization and structural learning, to formulate our task. And we propose a diversified collaborative filtering algorithm (DCF) to solve the coupled problems. We also introduce a new pairwise accuracy metric and a normalized topic coverage diversity metric to measure the performance of accuracy and diversity respectively. Extensive experiments on benchmark datasets show the performance gains of DCF in comparison with the state-of-the-art algorithms.
Far-infrared electron-paramagnetic-resonance spectrometer utilizing a quasioptical reflection bridge (1996)

We describe a far-infrared electron-paramagnetic-resonance (EPR) spectrometer for broadband (100–300 GHz) use. The spectrometer is operated in the reflection mode and uses broadband quasioptical methods to separate the transmitted from the reflected radiation. We describe and illustrate its operation at 170 GHz (1.8 mm) and compare its performance to that of our transmission mode spectrometer operating at 250 GHz. We also discuss the advantages of the reflection bridge for performing EPR experiments over a broad range of frequencies, and we consider methods of improving the performance of the bridge. This includes a novel design for variable coupling of the reflection-mode Fabry–Pérot resonator.
Studies on pyrrolidones. Synthesis and N‐alkylation of β‐enaminoesters derived from pyroglutamic acid (1992)

Abstract The condensation of iminoether 7 , derived from pyroglutamic acid (4) , with active methylene reagents such as Meldrum's acid or methyl cyanoacetate, lead to β‐enaminoesters 2 . Solid‐liquid phase transfer N ‐alkylation of these compounds is described.
[Pharmacological studies of a new sleep-inducer, 1H-1,2,4-triazolyl benzophenone derivatives (450191-S) (I). Behavioral analysis]. (1984)

The behavioral effects of 450191-S and its metabolites were investigated in mice, rats, cats and rhesus monkeys, and they were compared with those of related benzodiazepines (BDZ) such as diazepam and nitrazepam. Oral administration of 450191-S consistently caused sedation without excitability in mice and rats, and it was only 1/2 to 1/266 as potent as the BDZ in producing motor incoordination as assessed by traction, rotarod performance and inclined screen tests in mice, induced much less ataxia in cats and monkeys, and inhibited respiration in anesthetized cats. The locomotor activities of mice and rats measured by Animex and the open field test were not affected by 450191-S, but rearing and preening decreased with 450191-S as with the BDZ. 450191-S was equipotent with nitrazepam and 2 to 6 times more potent than diazepam and estazolam in potentiating chlorprothixene-induced hypnosis and thiopental-Na-induced anesthesia. These effects were not different with successive 14-day administration of 450191-S. Anti-pentylenetetrazol, picrotoxin and bicuculline convulsions of 450191-S had the same potency as nitrazepam, but caused much less anti-electroshock convulsion than the BDZ. 450191-S had potent antianxiety activity as observed by anti-aggressive and anti-conflict activities and had almost the same effect as diazepam on operant behavior. The metabolites M-1, M-2, M-A and M-3 showed approximately the same potency as 450191-S in inducing anesthetic potentiation and antianxiety activity, but they were much more potent in causing disturbance of the somatic functions. These results indicate that 450191-S possesses inhibitory effects on the central nervous system, including a potent sleep-inducing effect, and is characterized by markedly weak muscle relaxant activity and motor incoordination.
EyeSee3D: a low-cost approach for analysing mobile 3D eye tracking data using augmented reality technology (2014)

For validly analyzing human visual attention, it is often necessary to proceed from computer-based desktop set-ups to more natural real-world settings. However, the resulting loss of control has to be counterbalanced by increasing \nparticipant and/or item count. Together with the effort required to manually annotate the gaze-cursor videos recorded with mobile eye trackers, this renders many studies unfeasible.\n\nWe tackle this issue by minimizing the need for manual annotation of mobile gaze data. Our approach combines geo\\-metric modelling with inexpensive 3D marker tracking to align virtual proxies with the real-world objects. This allows us to classify fixations on objects of interest automatically while supporting a completely free moving participant.\n\nThe paper presents the EyeSee3D method as well as a comparison of an expensive outside-in (external cameras) and a low-cost inside-out (scene camera) tracking of the eyetracker's position. The EyeSee3D approach is evaluated comparing the results from automatic and manual classification of fixation targets, which raises old problems of annotation validity in a modern context.
Undisclosed material inflation risk (2023)

We identify many major U.S. corporations that are highly exposed to inflation risk. Yet, although the SEC legally requires disclosing possible risk factors, more than 61% of the inflation-exposed corporations do not disclose inflation risk. However, after being sued in a securities class action lawsuit, while all firms increase the length of their reported risk factor texts, only inflation-exposed firms are more likely to begin disclosing inflation risk. Simulations using calibrated parameters from our models reveal that 2%–6% inflation shocks over the subsequent three years result in market cap damages of $0.9 to $2.8 trillion for shareholders of inflation-exposed firms that never disclosed this risk. The inadequate inflation risk disclosure holds after allowing risk to be time varying, controlling for firm/industry characteristics, and/or exploiting a quasi-natural experiment that identifies causal effects and controls for possible unobservable factors. The evidence is consistent with corporate managers paying inadequate attention to inflation risk. Our framework enables identification and evaluation of stock price drop damages, especially for firms with inadequate risk disclosures, possibly improving disclosure practices, inflation expectations, and monetary policy transmission.
Light Scattering of Ultrafine Silica Particles by VUV Synchrotron Radiation (2005)

Vacuum ultraviolet (VUV) light scattering from ultrafine silica particles is studied with an aerosol instrument recently established at the Advanced Light Source (ALS) in Berkeley. Silica particles, size-selected by a differential mobility analyzer, are introduced into vacuum through a set of aerodynamic lenses to form a particle beam. The scattered photons from the crossing area of the VUV synchrotron beam and particle beam are detected with a rotatable VUV photon detector. The angular distributions of scattered photons (ADSP) originating from 70, 100, 200 nm diameter silica particles are measured with 145.9 and 118.1 nm synchrotron radiation. These angular distributions show strong forward scattering. The measured ADSPs are consistent with simulation of Mie scattering. The refractive indices of silica particles, 2.6 + 1.1i and 1.6 + 0.0001i for 118.1 and 145.9 nm, respectively, are obtained by fitting the measured ADSPs; the least average percentage deviations are 18% and 6%, respectively. The scattered fluxes at widely different wavelengths (visible versus VUV) also exhibit clear size sensitivity. Under comparable experimental conditions of photon fluxes and detection efficiencies, limits of particle size detection of 70 and 250 nm are obtained, respectively, when using 118.1 and 532 nm illumination. As anticipated, VUV scattering is a more sensitive probe for ultrafine particles, which will find application in detection of these ubiquitous species beyond the confines of a laboratory.
Dose response study of ipratropium bromide aerosol on maximum exercise performance in stable patients with chronic obstructive pulmonary disease. (1996)

A dose of at least four times the standard dose of ipratropium bromide from an MDI with a spacer device was necessary to improve maximal cycle exercise capacity in patients with stable COPD. Although the data from cycle ergometry cannot be directly applied to exercise performed during day to day activities, it is conceivable that the recommended doses of ipratropium bromide do not elicit the optimal clinical benefits.
Mango polyphenolics reduce inflammation in intestinal colitis-involvement of the miR-126/PI3K/AKT/mTOR axis in vitro and in vivo (2016)

This study sought to elucidate the mechanisms underlying the anti-inflammatory effect of mango (Mangifera Indica L.) polyphenolics containing gallic acid and gallotanins, and the role of the miR-126/PI3K/AKT/mTOR signaling axis in vitro and in vivo. Polyphenolics extracted from mango (var. Keitt) were investigated in lipopolysaccharide (LPS)-treated CCD-18Co cells. Rats received either a beverage with mango polyphenolics or a control beverage, and were exposed to three cycles of 3% dextran sodium sulfate (DSS) followed by a 2-wk recovery period. The mango extract (10 mg GAE/L) suppressed the protein expression of NF-κB, p-NF-κB, PI3K (p85β), HIF-1α, p70S6K1, and RPS6 in LPS-treated CCD-18Co cells. LPS reduced miR-126 expression, whereas, the mango extract induced miR-126 expression in a dose-dependent manner. The relationship between miR-126 and its target, PI3K (p85β), was confirmed by treating cells with miR-126 antagomiR where mango polyphenols reversed the effects of the antagomiR. In vivo, mango beverage protected against DSS-induced colonic inflammation (47%, P = 0.05) and decreased the Ki-67 labeling index in the central and basal regions compared to the control. Mango beverage significantly attenuated the expression of pro-inflammatory cytokines such as TNF-α, IL-1β, and iNOS at the mRNA and protein level. Moreover, the expression of PI3K, AKT, and mTOR was reduced, whereas, miR-126 was upregulated by the mango treatment. These results suggest that mango polyphenols attenuated inflammatory response by modulating the PI3K/AKT/mTOR pathway at least in part through upregulation of miRNA-126 expression both in vitro and in vivo; thus, mango polyphenolics might be relevant as preventive agents in ulcerative colitis. © 2016 Wiley Periodicals, Inc.