gebhart/patrepeval huggingface dataset:
Abstract A31: Activity-based protein profiling reveals adaptive response to pharmacological MEK inhibition in KRAS mutant non-small cell lung cancer (2014)

Abstract KRAS mutations account for development of approximately 30% of lung adenocarcinomas. While RAF-MEK-ERK signaling cascade is a key regulator of RAS-mediated proliferation and survival, the clinical efficacy of MEK inhibitors is still underwhelming in RAS-driven cancers. We treated KRAS mutant non-small cell lung cancer (NSCLC) cell lines with two MEK inhibitors (AZD6244 and MEK162) currently in clinical development. In all cell lines tested (N=11), we failed to observe significant effects on cell viability or induction of apoptosis. Because increasing evidence indicates that cancer cells undergo adaptive proteomic rewiring in response to kinase inhibitors, we performed activity-based protein profiling (ABPP) after treating 11 KRAS mutant NSCLC cell lines with MEK inhibitors in order to identify global enzymatic changes potentially involved in these adaptive processes. Our ABPP approach employs desthiobiotin-ATP probe, which enables selective labeling of active sites in ATP-binding proteins including kinases, chaperones and metabolic enzymes. Labeled proteins were subsequently purified and analyzed by mass spectrometry-based proteomics technique. Our ABPP results revealed that MEK inhibitors increased levels of multiple receptor tyrosine kinases (RTK) including EGFR and MET. MEK inhibitors induced MET phosphorylation and EGF-mediated AKT phosphorylation was markedly enhanced in the presence of MEK inhibitors, indicating increased RTK activity in adaptive response to MEK inhibition. We also found that MEK inhibition led to increased multiple heat shock proteins including HSP90 and HSP70, suggesting the possibility of chaperone-mediated adaptive resistance. Finally, MEK inhibitors globally increased enzymes involved in glucose utilization pathways implicating metabolic alterations in adaptive response to MEK inhibition. Collectively, our systematic activity-based proteomic profiling approach provides novel insights into adaptive resistance mechanisms to MEK inhibitors, suggesting rational combination treatment strategies for KRAS mutant NSCLC. Updated works will be presented. Citation Format: Jae-Young Kim, Bin Fang, Eric A. Welsh, Fumi Kinose, Jiannong Li, Steven A. Eschrich, John M. Koomen, Eric B. Haura. H. Activity-based protein profiling reveals adaptive response to pharmacological MEK inhibition in KRAS mutant non-small cell lung cancer. [abstract]. In: Proceedings of the AACR Special Conference on RAS Oncogenes: From Biology to Therapy; Feb 24-27, 2014; Lake Buena Vista, FL. Philadelphia (PA): AACR; Mol Cancer Res 2014;12(12 Suppl):Abstract nr A31. doi: 10.1158/1557-3125.RASONC14-A31
And you thought all flexible pump couplings were the same (2004)

Flexible couplings for pumps come in many types which can have widely different characteristics. However, too often these couplings are treated as virtually equivalent, leading to inappropriate installation and creating problems with the pump operation down the line. Jon Mancuso of Kop-Flex Emerson Power Transmission reviews the different types of flexible couplings available and the criteria that should be considered during their selection.
Endothelial Dysfunction and Collagen Accumulation (1999)

These results demonstrate that the severity of restenosis after angioplasty correlated with both defective endothelium-dependent relaxation and increased collagen density.
O2 (c¹Σu− → X³Σg−) emission in the terrestrial nightglow (1981)

Synthetic spectra have been calculated incorporating three O 2 emission systems, A ³Σ u + → X ³Σ g − , A′ ³Δ u → a ¹Δ g , and c ¹Σ u − → X ³Σ g − , and matched to the 3100‐ to 4500‐Å nightglow spectrum of Broadfoot and Kendall (1968). The synthesis necessitated the inclusion of the c ¹Σ u − → X ³Σ g − system, which has never been previously identified in the airglow, although it is a dominant system in the Venusian nightglow. The emissions from the extremely metastable A′ ³Δ u and c ¹Σ u − states account for half the radiation in the 3100‐ to 4500‐Å region, from which it may be deduced that the mesospheric concentrations of O 2 ( A′ ³Δ u ) and O 2 ( c ¹Σ u − ) are much higher than that of O 2 ( A ³Σ u + ). The vibrational distributions are quite unrelaxed for all three states.
Erythrobacter aquimaris sp. nov., isolated from sea water of a tidal flat of the Yellow Sea in Korea (2004)

Three Gram-negative, non-motile, non-spore-forming, slightly halophilic rods (strains SW-110(T), SW-116 and SW-140) were isolated from sea water of a tidal flat of the Yellow Sea in Korea and subjected to a polyphasic taxonomic study. The three isolates did not produce bacteriochlorophyll a and were characterized chemotaxonomically by having ubiquinone-10 as the predominant respiratory lipoquinone and C(18 : 1)omega7c and C(17 : 1)omega6c as the major fatty acids. The DNA G+C content of the three isolates was between 62.2 and 62.9 mol%. Strains SW-110(T), SW-116 and SW-140 showed no difference in their 16S rRNA gene sequences, and their mean level of DNA-DNA relatedness was 94.8 %. Phylogenetic analyses based on 16S rRNA gene sequences showed that the three strains form a distinct phylogenetic lineage within the cluster comprising Erythrobacter species. Similarities between the 16S rRNA gene sequences of strains SW-110(T), SW-116 and SW-140 and the type strains of Erythrobacter species ranged from 98.4 % (with Erythrobacter longus) to 97.7 % (with Erythrobacter flavus). Levels of DNA-DNA relatedness between strains SW-110(T), SW-116 and SW-140 and the type strains of all recognized Erythrobacter species were in the range 5.3-12.7 %. On the basis of polyphasic taxonomic data, strains SW-110(T), SW-116 and SW-140 were classified as a novel Erythrobacter species, for which the name Erythrobacter aquimaris sp. nov. is proposed. The type strain is SW-110(T) (=KCCM 41818(T)=JCM 12189(T)).
An Empirical Investigation on Trade Openness and Economic Growth in Bangladesh Economy (2012)

The objective of this paper is to assess the impact of trade liberalization on Bangladesh economy between the periods 1980 to 2010. This research analyzes the achievements of the economy in terms of important variables such as growth, inflation, export and import after trade liberalization. The paper uses simple Ordinary Least Square (OLS) technique as methodology for empirical findings. The analysis clearly indicates that GDP growth increased consequent to liberalization. Trade liberalization does not seem to have affected inflation in the economy. The quantitative analysis also suggests that greater openness has had a favourable effect on economic development. Both real export and imports have increased with greater openness. Liberalization policy certainly improves export of the country which eventually leads higher economic growth after 1990s. The findings of this study can be an interesting example for trade liberalization policy study in developing countries.
Agile Justin: An upgraded member of DLR's family of lightweight and torque controlled humanoids (2014)

This video presents the recent upgrades of the mobile humanoid Agile Justin, bringing it closer to an ideal platform for research in autonomous manipulation. Significant upgrades have been made in the fields of mechatronics, 3D sensors, tactile skin, massive GPGPU based computing power, and software communication framework. In addition, first algorithms and two experimental scenarios are presented that take advantage of these new capabilities.
Accumulation ofF-Spondinin Injured Peripheral Nerve Promotes the Outgrowth of Sensory Axons (1998)

F-spondin, an extracellular matrix protein, is present in peripheral nerve during embryonic development, but its amount diminishes by birth. Axotomy of adult rat sciatic nerve, however, causes a massive upregulation of both F-spondin mRNA and protein distal to the lesion. F-spondin in the distal stump of axotomized nerve promotes neurite outgrowth of sensory neurons, as revealed by protein neutralization with F-spondin-specific antibodies. Thus, F-spondin is likely to play a role in promoting axonal regeneration after nerve injury.
Towards a safety mechanism for platooning (2016)

Platooning has shown to be technically feasible, but safety aspects are still challenging. Wireless communication between vehicles allows to maintain reduced inter-vehicle distances, thereby improving traffic throughput and decreasing fuel consumption. As the driver can no longer be a backup at short inter-vehicle distances, the system needs to be fail-safe for both hazardous traffic situations as well as failures. In this paper, a scenario is defined which combines a hazardous traffic situation with a communication failure. First, the methodology for developing safety related functionality in automated driving is presented. This methodology combines aspects of the ISO26262 standard with the Harmony profile. Second, the safety mechanism to avoid a collision by braking is described. This ensures that a safe state can be reached for a set of use cases which are derived from the defined scenario. Finally, the proposed solution is tested in a simulation environment and is also implemented on test vehicles. The result of the simulations and experiments demonstrate the practical validity and show increased safety related functionality.
An algebraic approach to static analysis of active database rules (2000)

Rules in active database systems can be very difficult to program due to the unstructured and unpredictable nature of rule processing. We provide static analysis techniques for predicting whether a given rule set is guaranteed to terminate and whether rule execution is confluent (guaranteed to have a unique final state). Our methods are based on previous techniques for analyzing rules in active database systems. We improve considerably on the previous techniques by providing analysis criteria that are much less conservative: our methods often determine that a rule set will terminate or is confluent when previous methods could not make this determination. Our improved analysis is based on a “propagation” algorithm, which uses an extended relational algebra to accurately determine when the action of one rule can affect the condition of another, and determine when rule actions commute. We consider both conditon-action rules and event-condition-action-rules, making our approach widely applicable to relational active database rule languages and to the trigger language in the SQL:1999 standard.
Reflectron (2016)

This document contains recommendations for terminology in mass spectrometry. Development of standard terms dates back to 1974 when the IUPAC Commission on Analytical Nomenclature issued recommendations on mass spectrometry terms and definitions. In 1978, the IUPAC Commission on Molecular Structure and Spectroscopy updated and extended the recommendations and made further recommendations regarding symbols, acronyms, and abbreviations. The IUPAC Physical Chemistry Division Commission on Molecular Structure and Spectroscopy’s Subcommittee on Mass Spectroscopy revised the recommended terms in 1991 and appended terms relating to vacuum technology. Some additional terms related to tandem mass spectrometry were added in 1993 and accelerator mass spectrometry in 1994. Owing to the rapid expansion of the field in the intervening years, particularly in mass spectrometry of biomolecules, a further revision of the recommendations has become necessary. This document contains a comprehensive revision of mass spectrometry terminology that represents the current consensus of the mass spectrometry community.
A study of PCA image fusion techniques on remote sensing (2005)

We propose a PCA algorithm for image fusion between the infrared image and the visible image of the same night vision. The infrared image and the visible image are preprocessed with image Gaussian low-pass filter respectively, to smooth the images. The mathematical formulation of image fusion techniques is worked out in this paper. Included are block-based method, wavelet transform, wavelet packet and PCA. Experimental results show the effectiveness of the proposed method.
Enantioselective Palladium‐Catalyzed Decarboxylative Allylic Alkylations (2006)

Triple A: Recent developments in palladium-catalyzed decarboxylative asymmetric allylic alkylation (AAA) reactions provide easy access to highly enantioenriched ketones with α-positioned quaternary or tertiary carbon stereocenters under mild conditions.
Filtering of colored noise for speech enhancement and coding (1991)

Scalar and vector Kalman filters are implemented for filtering speech contaminated by additive white noise or colored noise, and an iterative signal and parameter estimator which can be used for both noise types is presented. Particular emphasis is placed on the removal of colored noise, such as helicopter noise, by using state-of-the-art colored-noise-assumption Kalman filters. The results indicate that the colored noise Kalman filters provide a significant gain in signal-to-noise ratio (SNR), a visible improvement in the sound spectrogram, and an audible improvement in output speech quality, none of which are available with white-noise-assumption Kalman and Wiener filters. When the filter is used as a prefilter for linear predictive coding, the coded output speech quality and intelligibility are enhanced in comparison to direct coding of the noisy speech.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Topological states on the breathing kagome lattice (2019)

We theoretically study the topological properties of the tight-binding model on the breathing kagome lattice with antisymmetric spin-orbit coupling (SOC) between nearest neighbors. We show that the system hosts nontrivial topological phases even without second-nearest-neighbor hopping and that the weakly dispersing band of the kagome lattice can become topological. The main results are presented in the form of phase diagrams, where the ${\mathbb{Z}}_{2}$ topological index is shown as a function of SOC (intrinsically allowed and Rashba) and lattice trimerization. In addition, exact diagonalization is compared with effective low-energy theories around the high-symmetry points. We find that the weakly dispersing band has a very robust topological property associated with it. Moreover, the Rashba SOC can produce a topological phase rather than hinder it, in contrast to the honeycomb lattice. Finally, we consider the case of a fully spin polarized (ferromagnetic) system, breaking time-reversal symmetry. We find a phase diagram that includes systems with finite Chern numbers. In this case too, the weakly dispersing band is topologically robust to trimerization.
Polymer-bound carbonic-carboxylic anhydride functions. Preparation, site-site interactions, and synthetic applications (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolymer-bound carbonic-carboxylic anhydride functions. Preparation, site-site interactions, and synthetic applicationsGary E. Martin, Manvendra B. Shambhu, Shukri R. Shakhshir, and George A. DigenisCite this: J. Org. Chem. 1978, 43, 24, 4571–4574Publication Date (Print):November 1, 1978Publication History Published online1 May 2002Published inissue 1 November 1978https://pubs.acs.org/doi/10.1021/jo00418a004https://doi.org/10.1021/jo00418a004research-articleACS PublicationsRequest reuse permissionsArticle Views138Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Silicon quantum dots in diamond matrix: a new synthesis route (2001)

Abstract Light‐emitting layers of silicon quantum dots embedded in a diamond matrix have been prepared by using a new hybrid chemical vapour deposition–powder flowing technique. The polycrystalline diamond matrix is grown by thermal activation of CH 4 –H 2 mixtures. The silicon nanoparticles used for the synthesis of the diamond‐based composites were prepared by CO 2 laser pyrolysis of SiH 4 –He mixtures in a gas flow reactor with controlled atmosphere. During the matrix deposition, the powder‐flowing apparatus drives the silicon nanoparticles across the active area of the substrate, where diamond is growing. A strong room temperature emission is observed from composite films with characteristics dependent on the size distribution of the inserted silicon particles. We report details of the synthesis procedure and emission features of composite diamond films, whose properties promise high technological impact. Copyright © 2001 John Wiley &amp; Sons, Ltd.
A CASE OF NEUROENDOCRINE CARCINOMA OF THE ILEUM WITH MULTIPLE LIVER METASTASIS PRESENTED WITH INTESTINAL OBSTRUCTION (2000)

A 41-year-old woman was admitted to the hospital because of intestinal obstruction. An ileus tube was inserted and we found out a complete obstruction of the ileum. Ultrasonography, CT scan and angiography visualized multiple liver tumors. With a suspicion of intestinal obstruction due to an ileum tumor and multiple liver metastasis, a partial resection of the ileum, a lateral segmentectomy and a cholecystectomy were performed. Histological examination revealed that the tumor of the ileum was atypical poorly differentiated adenocarcinoma (ss, ly0, v0, n0) and the tumor cells of both the ileum and liver had more undifferentiated appearance than carcinoid. Immunohistochemical stainings (grimelius, S-100, NSE) were positive, indicating that they have neuroendocrine differentiation. Electron microscopy revealed dense core granules. Therefore, it was diagnosed as neuroendocrine carcinoma of the ileum with multiple liver metastasis. After discharge, intra-arterial chemotherapy (FAM) was started on ambulant basis in the treatment of remaining liver tumors. The patient is alive 8 months after the operation with no sign of growing of the remnant tumors.
Adaptation to Competition by New Mutation in Clones of Alexandrium minutum (1998)

Eduardo Costas, Blanca Nieto, Victoria Lopez-Rodas, Conchita Salgado, Miguel Toro, Adaptation to Competition by New Mutation in Clones of Alexandrium minutum, Evolution, Vol. 52, No. 2 (Apr., 1998), pp. 610-613
THE FIRST EXPEDITION (2013)

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Recent experiments with liquid gallium cooling of crystal diffraction optics (abstract)a) (1992)

The x-ray beams for the next generation of synchrotrons will contain much more power (1–10 kW) than is available at present day facilities. Cooling the first optical components in these beam lines will require the best cooling technology that one can bring to bear. Argonne continues to pioneer the use of liquid metals as the cooling fluid and has adopted liquid gallium as the liquid metal of choice. Its low melting point, 29.7 °C and its very low vapor pressure make it an easy fluid to handle and its high thermal conductivity and heat capacity make it an excellent cooling fluid. A series of experiments were performed during April 1991 with the wiggler beam at the F2 station of the CHESS facility at Cornell to investigate the cooling of large areas of high power. Two types of cooling crystal geometries were tested, one where the cooling channels were core-drilled just below the surface of the crystal and a second where slots were cut into the crystal just below the surface with a diamond saw. Both crystals performed well with beam powers up to 1050 W and power densities of up to 14.5 W/mm2 at normal incidence. An infrared camera was used to measure the variation in the temperature of the top layer of the silicon crystals. For the core-drilled crystal the peak temperature measured at the center of the beam at a power density of 12.3 W/mm2 was 15 °C hotter than the crystal surface outside of the beam with a flow of liquid gallium of 2 gpm (gallons per minute) and was 10 °C with a flow of 4 gpm. The maximum distortion of the crystal surface distortion of the core drilled crystal was about ±2.0 arcsec for the 2 gpm case with a maximum power density of 10.9 W/mm2 and about 5% of the expected beam intensity was lost at peak power of 14.5 W/mm2. For the slotted crystal the peak temperature difference for a peak power of 10.9 W/mm2 was 3.5 and 2.0 °C for liquid gallium flows of 1 and 2 gpm, respectively. No intensity loss was measured for the maximum power density of 14.5 W/mm2. The fact that the peak temperature differences on the surface of both crystals was decreasing with increased flow of liquid gallium suggests that even higher power densities can be accommodated with higher flows of liquid gallium. This work is supported by the Department of Energy, BES-Materials Sciences, under Contract W-31-109-Eng-38.
Influence of thermodynamic state on nanojet break-up (2005)

Using non-equilibrium molecular dynamics, argon nanojet injection was simulated under vacuum conditions. A series of simulations with different shapes of solid platinum injectors was conducted. Observed droplet sizes and jet break-up characteristics resemble the Rayleigh break-up theory. However, the different injector shapes did not cause a significant change in the nanojet break-up behaviour. The liquid temperature inside the injector was found to be a controlling factor in determining the subsequent break-up characteristics. A higher liquid temperature is preferred for the faster nanojet break-up with the shorter break-up length.
Microanalysis of Autogenous Healing Products in Engineered Cementitious Composites (ECC) (2010)

Extended abstract of a paper presented at Microscopy and Microanalysis 2010 in Portland, Oregon, USA, August 1 – August 5, 2010.
ChemInform Abstract: MOLECULAR ADDITION COMPOUNDS. 9. EFFECT OF STRUCTURE ON THE REACTIVITIES OF REPRESENTATIVE BORANE‐AMINE COMPLEXES IN TYPICAL REACTIONS SUCH AS HYDROLYSIS, HYDROBORATION, AND REDUCTION (1984)

Abstract Die Boran‐Amin‐Komplexe (I)‐(III) werden aus BH 3‐THF und den entsprechenden, in ihren Strukturen sehr unterschiedlichen Aminen nach bekannten Methoden dargestellt.