gebhart/patrepeval huggingface dataset:
Treatment of T Cell Large Granular Lymphocyte Leukemia with Reduced-Intensity Allogeneic Stem Cell Transplantation. (2007)

T cell large granular lymphocyte (LGL) leukemia is a lymphoproliferative disorder of clonal CD3-positive cytotoxic T cells. Clinical manifestations include neutropenia, anemia, thrombocytopenia, recurrent infections and splenomegaly. Two patients with refractory LGL leukemia were treated with an allogeneic stem cell transplantation following a reduced-intensity conditioning regimen. The first patient was a 54 yo female with transfusion dependent anemia and splenomegaly. Prior therapy included low dose methotrexate, cyclosporin A, equine antithymocyte globulin and alemtuzumab. The second patient was a 34 yo female with lymphocytosis and recurrent infections. Prior therapy included cyclosporin A and splenectomy. The hematopoietic cell source was related donor peripheral blood stem cells (5.79 x 106 CD34+ cells/kg) for the first patient, and unrelated donor peripheral blood stem cells (8.04 x 106 CD34+ cells/kg) for the second patient. The preparative regimen was fludarabine 30mg/m2 daily on days −5, −4, −3; melphalan 140 mg/m2 on day −2; the unrelated donor recipient also received rabbit antithymocyte globulin 6mg/kg in 3 divided doses on days −3, −2, −1. GVHD prophylaxis was provided with tacrolimus and methotrexate 5mg/m2 on days +1, 3, 6, 11. Granulocyte engraftment &gt;0.5/μL occurred on day +20 and +11; platelet engraftment &gt;100/μL occurred on day +26 and +116 for the first and second patient respectively. The patient receiving the unrelated donor developed stage 1 skin GVHD and did not require systemic treatment. Patients achieved 100% donor chimerism by day 100. There was no chronic GVHD in either patient. Both patients achieved a complete remission and remain in CR, off immunosuppressive therapy, at 13 and 14 months post transplantation. Allogeneic transplantation using a reduced-intensity preparative regimen is an effective therapy for T cell large granular cell leukemia in patients who have failed prior therapy.
Non-thermal ablation of rabbit liver VX2 tumor by pulsed high intensity focused ultrasound with ultrasound contrast agent: Pathological characteristics (2008)

The non-thermal effects of PHIFU combined with UCA can be used to ablate rabbit liver VX2 tumors.
ChemInform Abstract: Highly Stereoselective Reduction of Acyclic α‐Sulfinyl Ketimines: Synthesis of Enantiomerically Pure β‐Aminosulfoxides. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Effects of Strain-Induced Crystallization on Mechanical Properties of Elastomeric Composites Containing Carbon Nanotubes and Carbon Black (2011)

고무복합재료에 대해 변형에 의한 결정화(SIC)가 기계적 특성에 미치는 영향을 연신율(λ) 및 다중벽 탄소나노튜브(CNT)와 카본블랙(CB)의 함유량을 함수로 하여 연구하였다. 시차 주사 열량(DSC) 분석을 통해 CB 및 CNT의 함유량에 따라 결정화 정도가 증가함을 확인 하였다. 또한 연신율이 증가함에 따라 복합재료의 유리전이온도(Tg)는 증가하였고, 결정화 잠열 값(LHc)은 λ=1.5에서 최대값을 보였다. CNT의 함유량 증가에 따라 기계적 특성과 LHc는 비례관계임을 확인하였다. 열 중량 분석(TGA)을 통해 기지의 소실율은 94.3%였고, 복합재료의 소실율은 보강재의 함유량 증가에 따라 감소하였다. 인장탄성율 비는 고무 내의 CNT 배향으로 인장강도 비보다 높게 나타났다.
Potential of Sulforaphane as a Natural Immune System Enhancer: A Review (2021)

Brassicaceae are an outstanding source of bioactive compounds such as ascorbic acid, polyphenols, essential minerals, isothiocyanates and their precursors, glucosinolates (GSL). Recently, GSL gained great attention because of the health promoting properties of their hydrolysis products: isothiocyanates. Among them, sulforaphane (SFN) became the most attractive one owing to its remarkable health-promoting properties. SFN may prevent different types of cancer and has the ability to improve hypertensive states, to prevent type 2 diabetes-induced cardiomyopathy, and to protect against gastric ulcer. SFN may also help in schizophrenia treatment, and recently it was proposed that SFN has potential to help those who struggle with obesity. The mechanism underlying the health-promoting effect of SFN relates to its indirect action at cellular level by inducing antioxidant and Phase II detoxifying enzymes through the activation of transcription nuclear factor (erythroid-derived 2)-like (Nrf2). The effect of SFN on immune response is generating scientific interest, because of its bioavailability, which is much higher than other phytochemicals, and its capacity to induce Nrf2 target genes. Clinical trials suggest that sulforaphane produces favorable results in cases where pharmaceutical products fail. This article provides a revision about the relationship between sulforaphane and immune response in different diseases. Special attention is given to clinical trials related with immune system disorders.
Detecting spatio-temporal outliers in crowdsourced bathymetry data (2013)

The widespread availability of Internet access and location-acquisition technologies, such as the global positioning system (GPS), has given rise to the growing phenomenon of Volunteered Geographic Information (VGI). Our work presents the use of VGI in bathymetry and hydrographic surveying and demonstrates that crowdsourced bathymetry data (CSB) can yield valuable knowledge for the maritime community. In this study, CSB data collected from 2012 to 2013 within the Baltimore Inner Harbor was used to locate anomalous depth measurements that could indicate the presence of submerged debris. To this end, we explored two approaches for detecting spatio-temporal outliers in the CSB data. In the first approach, we combined Local Outlier Factor and DBSCAN in an ensemble method to find spatio-temporal clusters of anomalous measurements that could indicate the presence of submerged debris. In the second approach, we calculated a measure of local spatial autocorrelation over time to identify "hotspots" or specific areas that consistently have low depth measurements compared to their immediate neighbors (i.e. "low-high" outliers). Results from both approaches revealed locations within the Fort McHenry Channel whose depth measurements may be indicative of the presence of submerged marine debris and, as such, may pose a threat to the safety of mariners operating in that region. Our results indicate that CSB data can not only help to improve the safety of mariners, but also serve to alert authorities in a timely manner that channel maintenance, a re-survey, and/or changes to the nautical chart may be needed.
CANPA: Computer-Assisted Natural Products Anticipation (2019)

Traditional natural products discovery workflows implying a combination of different targeting strategies including structure- and/or bioactivity-based approaches, afford no information about new compound structure until late in the discovery pipeline. By integrating a MS/MS prediction module and a collaborative library of (bio)chemical transformations, we have developed a new platform, coined MetWork, that is able of anticipating the structural identity of metabolites starting from any identified compound. In our quest to discover new monoterpene indole alkaloids, we demonstrate the utility of the MetWork platform by anticipating the structures of five previously undescribed sarpagine-like N-oxide alkaloids that have been targeted and isolated from the leaves of Alstonia balansae using a molecular networking-based dereplication strategy fueled by computer-generated annotations. This study constitutes the first example of a natural product discovery workflow, termed CANPA, in which the targeted structures were initially generated and therefore anticipated by a computer prior to their isolation.
Cloud Technology and Performance Improvement with Intserv over Diffserv for Cloud Computing (2014)

Cloud computing, bright venture of today and tomorrow, is rising based on the idea of the use of online information, software and hardware. Cloud computing provides users three different kinds of service models, infrastructure services, platform services and software services, which are in the run all together as requested and meets the needs of users. Benefits of cloud computing include increased security, monitoring and maintenance of the technical infrastructure by the provider, cost-savings, efficient use of resources, high flexibility, accessibility and device independence. This paper describes the cloud computing technology with its features and advantages in business life. Traffic of a medium-sized company is examined in two different scenarios, LAN network and cloud computing network, and compared according to ftp, email, HTTP traffics using OPNET. In second part of the study, DiffServ and IntServ quality of service terms are studied over cloud computing model. A new approach is studied in order to improve the performance of cloud computing network in a medium sized company by combining IntServ and DiffServ in same network model. This model serves an improvement in business applications using cloud computing technology.
Eisosomes and membrane compartments in the ascomycetes (2011)

Eisosomes are punctate structures located in the cytoplasmic side of the cell membrane of ascomycetes. In Saccharomyces cerevisiæ they coincide topologically with and are necessary for the organisation of specific membrane domains. The eisosomal proteins are universally and quite strictly conserved in the sub-phylum, however this evolutionary conservation is in apparent contradiction with an elusive functional significance. The comparative analysis of the eisosomes of S. cerevisiae and Aspergillus nidulans reveal striking differences in the assembly and developmental fate of these structures between these two model organisms.
Organ Dynamics and Hemodynamic of the Whole HH25 Avian Embryonic Heart, Revealed by Ultrasound Biomicroscopy, Boundary Tracking, and Flow Simulations (2019)

Congenital heart malformations occur to substantial number of pregnancies. Studies showed that abnormal flow biomechanical environments could lead to malformations, making it important to understand the biomechanical environment of the developing heart. We performed 4D high-frequency ultrasound scans of chick embryonic hearts at HH25 to study the biomechanics of the whole heart (atria and ventricle). A novel and high-fidelity motion estimation technique, based on temporal motion model and non-rigid image registration algorithm, allowed automatic tracking of fluid-structure boundaries from scan images, and supported flow simulations. Results demonstrated that atrial appendages were the most contractile portion of the atria, having disproportionately high contribution to atrial blood pumping for its volume in the atria. However, the atria played a small role in blood pumping compared to the ventricle, as it had much lower ejection energy expenditure, and as the ventricle appeared to be able to draw inflow from the veins directly during late diastole. Spatially and temporally averaged wall shear stresses (WSS) for various cardiac structures were 0.062-0.068 Pa, but spatial-averaged WSS could be as high as 0.54 Pa in the RV. WSS was especially elevated at the atrial inlet, atrioventricular junction, regions near to the outflow tract, and at dividing lines between the left and right atrium and left and right side of the ventricle, where septation had begun and the lumen had narrowed. Elevated WSS could serve as biomechanics stimulation for proper growth and development.
Mimicry of the calcium-induced conformational state of troponin C by low temperature under pressure. (1996)

Calcium binding to the N-domain of troponin C initiates a series of conformational changes that lead to muscle contraction. Calcium binding provides the free energy for a hydrophobic region in the core of N-domain to assume a more open configuration. Fluorescence measurements on a tryptophan mutant (F29W) show that a similar conformational change occurs in the absence of Ca2+ when the temperature is lowered under pressure. The conformation induced by subzero temperatures binds the hydrophobic probe bis-aminonaphthalene sulfonate, and the tryptophan has the same fluorescence lifetime (7 ns) as in the Ca2+-bound form. The decrease in volume (delta V = -25.4 ml/mol) corresponds to an increase in surface area. Thermodynamic measurements suggest an enthalpy-driven conformational change that leads to an intermediate with an exposed N-domain core and a high affinity for Ca2+.
Impact of Growth Rate on the Protein-mRNA Ratio in Pseudomonas aeruginosa (2022)

Our understanding of how bacterial pathogens colonize and persist during human infection has been hampered by the limited characterization of bacterial physiology during infection and a research bias toward <i>in vitro</i>, fast-growing bacteria. Recent research has begun to address these gaps in knowledge by directly quantifying bacterial mRNA levels during human infection, with the goal of assessing microbial community function at the infection site. However, mRNA levels are not always predictive of protein levels, which are the primary functional units of a cell. Here, we used carefully controlled chemostat experiments to examine the relationship between mRNA and protein levels across four growth rates in the bacterial pathogen Pseudomonas aeruginosa. We found a genome-wide positive correlation between mRNA and protein abundances across all growth rates, with genes required for P. aeruginosa viability having stronger correlations than nonessential genes. We developed a statistical method to identify genes whose mRNA abundances poorly predict protein abundances and calculated an RNA-to-protein (RTP) conversion factor to improve mRNA predictions of protein levels. The application of the RTP conversion factor to publicly available transcriptome data sets was highly robust, enabling the more accurate prediction of P. aeruginosa protein levels across strains and growth conditions. Finally, the RTP conversion factor was applied to P. aeruginosa human cystic fibrosis (CF) infection transcriptomes to provide greater insights into the functionality of this bacterium in the CF lung. This study addresses a critical problem in infection microbiology by providing a framework for enhancing the functional interpretation of bacterial human infection transcriptome data. <b>IMPORTANCE</b> Our understanding of bacterial physiology during human infection is limited by the difficulty in assessing bacterial function at the infection site. Recent studies have begun to address this question by quantifying bacterial mRNA levels in human-derived samples using transcriptomics. One challenge for these studies is the poor predictivity of mRNA for protein levels for some genes. Here, we addressed this challenge by measuring the transcriptomes and proteomes of P. aeruginosa grown at four growth rates. Our results revealed that the growth rate does not impact the genome-wide correlation of mRNA and protein levels. We used statistical methods to identify the genes for which mRNA and protein were poorly correlated and developed an RNA-to-protein (RTP) conversion factor that improved the predictivity of protein levels across strains and growth conditions. Our results provide new insights into mRNA-protein correlations and tools to enhance our understanding of bacterial physiology from transcriptome data.
Diffraction, scattering and impedance loading : final report, September 1976-September 1972 (1972)

http://deepblue.lib.umich.edu/bitstream/2027.42/7533/5/bad2171.0001.001.pdf
Binaural benefit for speech recognition with spectral mismatch across ears in simulated electric hearing (2011)

The present study investigated the effects of binaural spectral mismatch on binaural benefits in the context of bilateral cochlear implants using acoustic simulations. Binaural spectral mismatch was systematically manipulated by simulating changes in the relative insertion depths across ears. Sentence recognition, presented unilaterally and bilaterally, were measured in normal-hearing listeners in quiet and noise at +5 dB signal-to-noise ratio. Significant binaural benefits were observed when the interaural difference in insertion depth was 1 mm or less. This result suggests a dependence of the binaural benefit on redundant speech information, rather than on similarity in performance across ears.
Preparation and Properties of Carbon Dot‐Grafted CaAl12O19:Mn4+ Color‐Tunable Hybrid Phosphor (2015)

A series of carbon dots (CDs) grafted CaAl 12 O 19 :Mn 4+ (CAO) color‐tunable hybrid phosphors have been synthesized via a facile sol‐gel method. Through the hydrolysis and condensation reactions of the silica precursor, CDs can be incorporated into highly flexible hybrid materials through combining with a CaAl 12 O 19 :Mn 4+ phosphor within silica gel networks for the fabrication of flexible displays and multicolor luminescent materials. By tuning the mass ratio of CDs/CAO and by adjusting the excitation wavelength, the color of the luminescence can be systematically tailored from purplish‐red (0.504, 0.250) to greenish‐blue (0.238, 0.192). Furthermore, the temperature‐dependent luminescent properties of the CDs/CAO phosphors makes them suitable as thermometers with a wide linear temperature sensing range from 80 to 300 K.
Alternating Direction Algorithms for $\ell_1$-Problems in Compressive Sensing (2009)

In this paper, we propose and study the use of alternating direction algorithms for several $\ell_1$-norm minimization problems arising from sparse solution recovery in compressive sensing, including the basis pursuit problem, the basis-pursuit denoising problems of both unconstrained and constrained forms, as well as others. We present and investigate two classes of algorithms derived from either the primal or the dual forms of the $\ell_1$-problems. The construction of the algorithms consists of two main steps: (1) to reformulate an $\ell_1$-problem into one having partially separable objective functions by adding new variables and constraints; and (2) to apply an exact or inexact alternating direction method to the resulting problem. The derived alternating direction algorithms can be regarded as first-order primal-dual algorithms because both primal and dual variables are updated at each and every iteration. Convergence properties of these algorithms are established or restated when they already exist. Extensive numerical results in comparison with several state-of-the-art algorithms are given to demonstrate that the proposed algorithms are efficient, stable and robust. Moreover, we present numerical results to emphasize two practically important but perhaps overlooked points. One point is that algorithm speed should always be evaluated relative to appropriate solution accuracy; another is that whenever erroneous measurements possibly exist, the $\ell_1$-norm fidelity should be the fidelity of choice in compressive sensing.
A Double‐Blind Placebo Controlled Evaluation of the Safety and Efficacy of Vinpocetine in the Treatment of Patients with Chronic Vascular Senile Cerebral Dysfunction (1987)

In a double-blind clinical trial, vinpocetine, a synthetic ethyl ester of apovincamine, was shown to effect significant improvement in elderly patients with chronic cerebral dysfunction. Forty-two patients received 10 mg vinpocetine three times a day (tid) for 30 days, then 5 mg tid for 60 days. Matching placebo tablets were given to another 42 patients for the 90 day trial period. Patients on vinpocetine scored consistently better in all evaluations of the effectiveness of treatment including measurements on the Clinical Global Impression (CGI) scale, the Sandoz Clinical Assessment-Geriatric (SCAG) scale, and the Mini-Mental Status Questionnaire (MMSQ). There were no serious side effects related to the treatment drug.
Promoting collaboration: the physical arrangement of library computers (2009)

Purpose The purpose of this conceptual paper is to highlight the increasing need for libraries to support collaborative learning and to review possible physical arrangements of computer laboratories that are supportive of collaborative learning. Design/methodology/approach A review of the literature was conducted to look at the interface of the concepts of collaborative learning and physical arrangements of computer laboratories. Findings The review of the literature surfaced four suggested physical arrangements of computers for collaborative work; kidney‐shaped tables, trapezoid tables and half‐circle tables, and Center for Science, Mathematics and Technology Education sociopetal workstations. After reviewing these arrangements, the paper suggest an additional arrangement with increased potential for face to face collaboration; full‐circle with recessed monitors. Originality/value As new libraries are built and others renovated, these five physical arrangements provide for ways that computer laboratories can be designed to meeting the increasing need for user collaboration.
An Introduction to Source Coding (1993)

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The immobilized matrix buffer controls the rate of mitochondrial respiration in state 3P according to chance. (1997)

Preparations of coupled mitochondria were labeled with fluorescein isothiocyanate (FITC). Comparison of characteristics of FITC bound to mitochondria versus azolectin liposomes indicates that a significant part of the probe is bound to mitochondrial proteins including proteins of the matrix side of the inner membrane. The experiments with the probe indicate that mitochondrial proteins resemble typical polyelectrolytes with constant of dissociation close to 10(-7).H+ and K+ compete for binding to mitochondrial proteins at neutral pH. The slow deprotonation of matrix proteins is observed during equilibration of matrix protons with medium protons. This process is not restricted to the transmembrane proton transfer. The data are explained by the theory of immobilized buffer. Under certain conditions the extent of dissociation of the matrix immobilized buffer correlates with the rate of mitochondrial respiration in state 3P according to chance.