gebhart/patrepeval huggingface dataset:
Time-Prolonged Release of Tumor-Targeted Protein–MMAE Nanoconjugates from Implantable Hybrid Materials (2022)

The sustained release of small, tumor-targeted cytotoxic drugs is an unmet need in cancer therapies, which usually rely on punctual administration regimens of non-targeted drugs. Here, we have developed a novel concept of protein-drug nanoconjugates, which are packaged as slow-releasing chemically hybrid depots and sustain a prolonged secretion of the therapeutic agent. For this, we covalently attached hydrophobic molecules (including the antitumoral drug Monomethyl Auristatin E) to a protein targeting a tumoral cell surface marker abundant in several human neoplasias, namely the cytokine receptor CXCR4. By this, a controlled aggregation of the complex is achieved, resulting in mechanically stable protein-drug microparticles. These materials, which are mimetics of bacterial inclusion bodies and of mammalian secretory granules, allow the slow leakage of fully functional conjugates at the nanoscale, both in vitro and in vivo. Upon subcutaneous administration in a mouse model of human CXCR4<sup>+</sup> lymphoma, the protein-drug depots release nanoconjugates for at least 10 days, which accumulate in the tumor with a potent antitumoral effect. The modification of scaffold cell-targeted proteins by hydrophobic drug conjugation is then shown as a novel transversal platform for the design of slow releasing protein-drug depots, with potential application in a broad spectrum of clinical settings.
Regulated Hydrogen Peroxide Production by Duox in Human Airway Epithelial Cells (2005)

Hydrogen peroxide (H(2)O(2)) is found in exhaled breath and is produced by airway epithelia. In addition, H(2)O(2) is a necessary substrate for the airway lactoperoxidase (LPO) anti-infection system. To investigate the source of H(2)O(2) produced by airway epithelia, PCR was used to screen nicotinamide adenine dinucleotide phosphate (NADPH) oxidase expression in human airway epithelia redifferentiated at the air-liquid interface (ALI) and demonstrated the presence of Duox1 and 2. Western blots of culture extracts indicated strong expression of Duox, and immunohistochemistry of human tracheal sections localized the protein to the apical portion of epithelial cells. Apical H(2)O(2) production was stimulated by 100 microM ATP or 1 microM thapsigargin, but not 100 microM ADP. Diphenyleneiodonium, an NADPH oxidase inhibitor, and dimethylthiourea, a reactive oxygen species scavenger, both inhibited this stimulation. ATP did not stimulate the basolateral H(2)O(2) production by ALI cultures. ATP and thapsigargin increased intracellular Ca(2+) with kinetics similar to increasing H(2)O(2) production, and thus consistent with the expected Ca(2+) sensitivity of Duox. These data suggest that Duox is the major NADPH oxidase expressed in airway epithelia and therefore a contributor of H(2)O(2) production in the airway lumen. In addition, the data suggest that extracellular H(2)O(2) production may be regulated by stimuli that raise intracellular Ca(2+).
Two New Carbazole Alkaloids from Murraya koenigii (2003)

Two new carbazole alkaloids named murrayanine (1) and 8,8' '-biskoenigine (2) were isolated from Murraya koenigii. The structure elucidations for 1 and 2 were carried out on the basis of 1D and 2D NMR experiments. Compound 1 was a novel carbazole alkaloid with a rare phenylpropanyl substitution. Compound 2 was a symmetrical dimer of the carbazole alkaloid koenigine and showed antiosteoporotic activity in the CAT-B model with IC(50) 1.3 microg/mL. The synthesis of 2 from koenigine was carried out through oxidative coupling using a solid state reaction.
Advanced EMI Modeling and Processing Approaches for UXO Discrimination (2006)

This paper presents a new, advanced non-traditional physics based inverse-scattering approach for determining a buried object's location and orientation. The approach combines an advanced electromagnetic induction (EMI) forward model called the normalized surface magnetic charge model (NSMC) with the pole series expansions technique. First, the NSMC is used to generate bi-static EMI data from actual measured mono-static data, and then the pole series expansion approach is employed to localize scattered field singularities, i.e. to find object's location and orientation. Once the object's location and orientations are found, then the total NSMC, which is characteristic of the object, is calculated and used as a discriminant. The algorithm is tested against actual EM-63 time domain EMI data collected at the ERDC test-stand site for an actual UXO. Several numerical results are presented to demonstrate the applicability of the proposed method for UXO discrimination
Reactions of Cyclopalladated Benzylidene‐aniline Schiff's Base Complexes. Selective Synthesis of 2′‐Substituted Schiff's Base Derivatives and the X‐Ray Crystal Structure of the Dimer [Pd(μ‐OAc)(5′‐OCH3C6H3CHNC6H4‐4‐CH3)]2 (1985)

Abstract The 2′‐cyclopalladated imine complex , reacts with CO in MeOH to afford the 2′‐substituted aryl imine 2′‐CO 2 CH 3 ‐5′‐OCH 3 C 6 H 3 CHNTol (Tol = C 6 H 4 ‐4‐CH 3 ). The product of this reaction can be altered by changing the bridging ligand from AcO to Cl, in which case only the 5‐membered ring heterocyclic compound is obtained. [Pd(μ‐OAc)( 1a )] 2 with 2 equiv. of Ph 3 P and CO (1 atm) gives the heterocyclic which arises from two CO insertion reactions, whereas [PdX( 1a )] 2 (X = AcO, Cl) with 4 equiv. of CNBu t and 4 equiv. of Ph 2 PCH 2 CH 2 PPh 2 affords the heterocyclic ketenimine [PdCl( 1a )] 2 reacts with CH 2 CHCO 2 CH 2 CH 3 to afford 2′(CHCHCO 2 CH 2 CH 3 )‐5′‐OCH 3 C 6 H 3 CHO, and [Pd(μ‐OAc)( 1a )] 2 with I 2 to give 2′‐I‐5′‐OCH 3 C 6 H 3 CHO. Excess CH 3 O 2 CCCCO 2 CH 3 reacts with various substituted cyclopalladated Schiff 's bases in MeOH to afford which we formulate as possessing two PdC bonds, and one coordinated ester O atom. The X‐ray crystal structure of [Pd(μ‐OAc)( 1a )] 2 has been determined; relevant bond lengths [Å] and bond angles [°] are: PdO(1), 2.139(6), PdO(2), 2.026(6), PdN, 2.039(6), PdC(2′), 1.951(8), PdPd, 3.113(1), NPdC(2′), 80.9(3), NPdO(1), 97.5(2), C(2′)PdO(2), 91.7(3), O(1)PdO(2), 89.2(2).
NIMG-53A FUZZY-BASED MODEL TO PREDICT THE SURVIVAL RATE OF PATIENTS WITH GIOBLASTOMA MLTIFORME TUMOR (2015)

Prediction of patient survival with brain tumor can play an important role in treatment planning and quality of a patient's life. This study investigates the effect of permeability and perfusion parameters on survival rate. This study identifies the most effective parameters on the survival time and then combines these parameters with experts' knowledge to construct a fuzzy-based model for predicting the survival rate of patients with Glioblastoma Multiforme (GBM). 25 treatment-naive GBM patients were studied using Dynamic Contrast Enhanced Magnetic Resonance Imaging. Using the standard Toft-model combined with Model Selection technique and Maximum-Likelihood algorithm, for each patient, the following permeability parameters were estimated: plasma volume (vp), outward and inward transfer constants (ktrans and kep). The estimated parameters were averaged across the tumor volume for each patient. Histogram of each parameter in whole volume of tumor was calculated and a Normal distribution was assigned to each histogram. Mean and standard deviation of each normal distribution were used to calculate the probability of each parameter being effective on survival rate. All the estimated parameters along with age, gender and hemodynamic parameters (relative Cerebral Blood Volume, rCBV and Cerebral Blood Flow, rCBF) were used as independent features for Cox-proportional-hazard regression model and Wald-test for survival analysis and to identify the parameters with most predictive power of survival. This pilot study revealed that the following physiological parameters are the best candidates to construct the fuzzy-based model for prediction of GBM patient survival: Mean and standard deviation of kep and extra-vascular extra-cellular volume (ve = ktrans/kep), vp, patient age, and rCBV. Compared to the other conventional predictors, the proposed model in this study showed a superior predictive power (∼ 93%) which is due to the fact that it can benefit from experimental data and a set of rules that can be constructed based on the knowledge of experts.
ChemInform Abstract: MIKROBIOLOGISCHE HYDROXYLIERUNG VON DIOXYGENIERTEN 5ALPHA‐ANDROSTANEN MIT KULTUREN DES PILZES CALONECTRIA DECORA (1973)

Abstract Dioxygenierte Sa‐Androstane lassen sich leichter hydroxylieren als monooxygenierte Substrate.
Using LSTMs to learn physiological models of blood glucose behavior (2017)

For people with type 1 diabetes, good blood glucose control is essential to keeping serious disease complications at bay. This entails carefully monitoring blood glucose levels and taking corrective steps whenever they are too high or too low. If blood glucose levels could be accurately predicted, patients could take proactive steps to prevent blood glucose excursions from occurring. However, accurate predictions require complex physiological models of blood glucose behavior. Factors such as insulin boluses, carbohydrate intake, and exercise influence blood glucose in ways that are difficult to capture through manually engineered equations. In this paper, we describe a recursive neural network (RNN) approach that uses long short-term memory (LSTM) units to learn a physiological model of blood glucose. When trained on raw data from real patients, the LSTM networks (LSTMs) obtain results that are competitive with a previous state-of-the-art model based on manually engineered physiological equations. The RNN approach can incorporate arbitrary physiological parameters without the need for sophisticated manual engineering, thus holding the promise of further improvements in prediction accuracy.
Initial Tap Setup of Constant Modulus Algorithm for Polarization De-multiplexing in Optical Coherent Receivers (2009)

We demonstrate a modified constant modulus algorithm (CMA) for polarization de-multiplexing and equalization. By designing the initial tap values for CMA, degeneration of the two polarization tributaries can be avoided.
Peculiar Magnetic Property of Pyrolytic Carbon Prepared From Adamantane (1992)

Abstract Magnetic-property measurements of pyrolytic carbon prepared by the thermal CVD of adamantane were carried out using the Faraday balance method and the ESR spectroscopy. The content of ferromagnetic metallic oxide as impurity in the samples has been confirmed to be low enough not to influence on the present magnetic-property measurements. Analysis of the measurement results has shown that the sample obtained are basically superparamagnetic and, even, ferromagnetic at low temperatures in a certain sample.
Airborne measurements of Space Shuttle exhaust constituents (1983)

Airborne measurements of hydrogen chloride (HCl) and particulates made during penetrations into and flights under Space Shuttle exhaust clouds from launches STS-1, -2, and -5 are presented to permit comparison with dispersion model predictions for Space Shuttle exhaust clouds, and with previous measurements made in Titan III exhaust clouds. Analytical techniques employed for the Shuttle measurements were developed and refined during earlier Titan III exhaust cloud measurements and include the measurements of particulate concentrations, size distributions, and the partitioning of HCl between the gaseous and aerosol phases. The results are useful in understanding the dynamics of ground cloud development, atmospheric dispersion, and potential environmental effects of Shuttle effluents.
Mice Deficient in Hepsin, a Serine Protease, Exhibit Normal Embryogenesis and Unchanged Hepatocyte Regeneration Ability (2000)

Hepsin, a liver-enriched novel serine protease, has been implicated in participating with normal cell growth, embryogenesis, and blood coagulation pathway. To study its function in vivo, we have disrupted the mouse hepsin gene by homologous recombination. Targeted disruption of the hepsin gene and ablation of hepsin message were demonstrated by Southern blotting, Northern blotting and RT-PCR analysis. Homozygous hepsin -/- mice were viable, fertile, and exhibited no gross abnormalities, as judged by the size, weight and blood coagulation (PT) assays. However, the serum concentration of the bone form of alkaline phosphatase, aspartate aminotransferase, and alanine aminotransferase of the hepsin -/- mice was mildly elevated, in spite of no obvious pathological change of hepatocytes. To examine whether hepsin is involved in controlling cell growth in adult tissues, 70% hepatectomy was applied to the hepsin -/- mice. Liver regeneration proceeded normally in the hepsin -/- mice as judged by the liver mass restoration rate. These results suggest that loss of hepsin function causes no effect in cell growth and embryogenesis in vivo, which is in contradiction to the studies using in vitro cell culturing system. Moreover, gross mass regeneration of liver after damage proceeds normally in the absence of functional hepsin.
Chlorine and HCl radical beam etching of III–V semiconductors (1990)

This work presents etch rate versus temperature data for GaAs and InP etched by Cl2 and HCl both with and without a remote plasma. The data is described both qualitatively and quantitatively by a thermodynamic model utilizing reactant-flux-limited and product-desorption-limited regimes. This ‘‘ionless’’ etching technique demonstrates reactant-flux-limited, temperature-independent behavior for HCl etching of GaAs for over five orders of magnitude of flux. InP and GaAs show nearly equirate etching at T&amp;gt;150 °C with both gases. Reactive ion etching (RIE) with Cl2 of InP at elevated temperatures produces only moderate rate enhancements; RIE gave a maximum etch rate of ∼800 Å/min at 175 °C compared to ∼0.5 μm/min obtained with the remote plasma system at the same temperature.
Neural-vascular relationships in central retina of macaque monkeys (Macaca fascicularis) (1992)

The relationship of the vasculature to the neuronal layers was studied in whole-mounts and in sections of macaque retinas. Like other central nervous structures, primate retinas have local variations in vascularity that reflect local variations in metabolism, rather than simply tissue thickness or volume. A special feature of the retina is a dense vascular plexus in the nerve fiber layer, which is unmyelinated and hence must generate a substantial metabolic demand for ion pumping. Much of the retinal vasculature is laminated and located at specific layer boundaries. Throughout the central retina, two planes of capillaries bracket the inner nuclear layer to form a sclerad capillary network. In some regions, especially near the fovea, a second, more vitread network brackets the ganglion cell layer with another pair of capillary planes. Wherever the nerve fiber layer is thick, the vitread network becomes less planar and is multilayered. When surrounded by nerve fibers, capillaries tend to orient parallel to the fibers; when adjacent to ganglion cell bodies, the capillaries are less systematically oriented. At the border between the nerve fiber layer and the ganglion cell layer, rows of ganglion cells often interdigitate with nerve fiber bundles, resulting in local perturbations of capillary orientation. The volume of the sclerad capillary network is relatively constant at different locations, but the volume of the vitread network increases dramatically where the nerve fiber layer is thick. As a result, the vascularity of the retina is greatest in the peripapillary region near the optic disk, even though the total thickness of the peripapillary retina is comparable to the retinal thickness near the foveal crest. As many as 60-70% of the photons passing through the retina in the peripapillary region will encounter one or more capillaries before reaching a photoreceptor. Median capillary diameter increases with retinal depth from 4.5-4.7 microns in the nerve fiber layer to 5.0 microns at the sclerad border of the inner nuclear layer. Capillary diameter in the nerve fiber layer also increases near the optic disk.
Trisomy 11: an association with stem/progenitor cell immunophenotype (1995)

The clinicopathological features and the prognostic significance of acute myeloid leukaemia (AML) with trisomy 11 are currently unknown. In this study we describe 15 adult AML cases with trisomy 11. Trisomy 11 was the sole chromosomal anomaly in eight cases; the remaining seven cases were characterized by +11 in association with other karyotypic aberrations. Patients ages ranged from 34 to 79 years. 12 patients were male; three were female. Although there was no correlation of trisomy 11 with any specific FAB subgroup [M2 (n = 7), M1 (n = 5), M4/5 (n = 2), M3 (n = 1)] less mature forms predominated. Immunologically, the leukaemic blasts showed a strikingly consistent stem cell phenotype with expression of HLA-DR, CD34 and the myeloid antigens (CD15, CD33 and/or CD13). In addition, two cases expressed the B-cell associated antigen CD19. The presence of trilineage dysplasia, suggesting the presence of an underlying myelodysplasia (MDS), was observed at presentation in five cases; in another case MDS was evident at relapse only. Unexpectedly, MLL gene rearrangements were observed in two of four cases characterized by trisomy 11 as the sole karyotypic abnormality; however, MLL aberrations were not identified in three cases with trisomy 11 accompanied by other karyotypic anomalies. The majority of patients in each subgroup (i.e. those with and without additional cytogenetic abnormalities) achieved a short first complete remission (CR) (mean 8 months) and failed to obtain a second CR. Only one patient in each trisomy 11 subgroup is in a continuous CR for > 34 months. These findings suggest that trisomy 11 leukaemia is characterized by a stem/progenitor cell immunophenotype with poor response to standard chemotherapeutic regimens and an unfavourable prognosis.
First for China! (1997)

KENJI TAKAYAMA, KAWASAKI HEAVY INDUSTRIES LTD, JAPAN, INTRODUCES THE CKK SYSTEM, WHICH HAS BEEN INSTALLED AT THE TONGLING CONCH PLANT IN CHINA.
Mn-Mimochrome VI*a: An Artificial Metalloenzyme With Peroxygenase Activity (2018)

Manganese-porphyrins are important tools in catalysis, due to their capability to promote a wide variety of synthetically valuable transformations. Despite their great reactivity, the difficulties to control the reaction selectivity and to protect the catalyst from self-degradation hamper their practical application. Compared to small-molecule porphyrin complexes, metalloenzymes display remarkable features, because the reactivity of the metal center is finely modulated by a complex interplay of interactions within the protein matrix. In the effort to combine the catalytic potential of manganese porphyrins with the unique properties of biological catalysts, artificial metalloenzymes have been reported, mainly by incorporation of manganese-porphyrins into native protein scaffolds. Here we describe the spectroscopic and catalytic properties of Mn-Mimochrome VI<sup>*</sup>a (Mn-MC6<sup>*</sup>a), a mini-protein with a manganese deuteroporphyrin active site within a scaffold of two synthetic peptides covalently bound to the porphyrin. Mn-MC6<sup>*</sup>a is an efficient catalyst endowed with peroxygenase activity. The UV-vis absorption spectrum of Mn-MC6<sup>*</sup>a resembles that of Mn-reconstituted horseradish peroxidase (Mn-HRP), both in the resting and high-valent oxidized states. Remarkably, Mn-MC6<sup>*</sup>a shows a higher reactivity compared to Mn-HRP, because higher yields and chemoselectivity were observed in thioether oxidation. Experimental evidences also provided indications on the nature of the high-valent reactive intermediate and on the sulfoxidation mechanism.
Comparison of Cardiotocography and Fetal Heart Rate Estimators Based on Non-Invasive Fetal ECG (2019)

Non-invasive fetal ECG (NI-FECG) extraction algorithms enable long-term continuous beat-to-beat monitoring of the fetal heart rate (FHR), as opposed to the gold standard in FHR monitoring, cardiotocography (CTG). We investigate how NI-FECG extraction algorithms selected from the CinC 2013 Challenge (CinC13) perform on data with low quality signals and how performance can be evaluated using CTG, when FQRS annotation is not possible.Four-channel NI-FECG was recorded simultaneously with a CTG trace on 22 pregnant women, gestational age 29-41 weeks. Seven algorithms were tested: The winning CinC13 entry from Varanini et al. and six algorithms from the unofficial top-scoring CinC13 entry by Behar et al. Two accuracy measures were used: 1) The RMSE between the FECG-based FHR and CTG traces; 2) The Pearson correlation coefficient r between the FECG-based FHR and CTG trace and its average over all recordings, $\bar r$.The algorithms with the lowest RMSE’s are Behar’s FUSE-SMOOTH, a constant FHR, and Varanini, while the Varanini algorithm delivers the best correlation with the CTG trace $(\bar r = 0.73)$ with 41% of the recordings having r > 0.8, whereas the other algorithms have $\bar r \leq 0.59$ and ≤ 29% of the recordings with r > 0.8. FHR was estimated accurately in some recordings and poorly in others, believed to be due to large differences in signal quality.
Substituent effects. 8. Basic strength of azatriptycene, triphenylamine, and some related amines (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSubstituent effects. 8. Basic strength of azatriptycene, triphenylamine, and some related aminesA. J. Hoefnagel, M. A. Hoefnagel, and B. M. WepsterCite this: J. Org. Chem. 1981, 46, 21, 4209–4211Publication Date (Print):October 1, 1981Publication History Published online1 May 2002Published inissue 1 October 1981https://doi.org/10.1021/jo00334a021RIGHTS & PERMISSIONSArticle Views517Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (452 KB) Get e-Alerts Get e-Alerts
Enhanced sensitivity of surface plasmon resonance phase-interrogation biosensor by using oblique deposited silver nanorods (2014)

Sensitivity of surface plasmon resonance phase-interrogation biosensor is demonstrated to be enhanced by oblique deposited silver nanorods. Silver nanorods are thermally deposited on silver nanothin film by oblique angle deposition (OAD). The length of the nanorods can be tuned by controlling the deposition parameters of thermal deposition. By measuring the phase difference between the p and s waves of surface plasmon resonance heterodyne interferometer with different wavelength of incident light, we have demonstrated that maximum sensitivity of glucose detection down to 7.1 × 10(-8) refractive index units could be achieved with optimal deposition parameters of silver nanorods.