gebhart/patrepeval huggingface dataset:
The Natural History of Fetomaternal Alloimmunization to the Platelet-Specific Antigen HPA-1a (PlA1, Zwa) as Determined by Antenatal Screening (1998)

Immunization against the human platelet antigen (HPA)-1 alloantigen is the most common cause of severe fetal and neonatal thrombocytopenia. Fetal therapy has substantial risks and its indications need better definition. Of 24,417 consecutive pregnant women, 618 (2.5%) were HPA-1a negative of whom 385 entered an observational study. All were HLA-DRB3*0101 genotyped and screened for anti–HPA-1a. Their partners and neonates were HPA-1 genotyped and the latter were assessed by cord blood platelet counts and cerebral ultrasound scans. Anti–HPA-1a was detected in 46 of 387 pregnancies (12.0%; 95% CI 8.7%-15.2%). All but one were HLA-DRB3*0101 positive (odds ratio 140; 95% CI 19-1035;P&lt; .00001). One baby died in utero, and of 26 HPA-1a–positive babies born to women with persistent antenatal antibodies, 9 were severely thrombocytopenic (8 with a count &lt;10 × 109/L, 1 with a large porencephalic cyst), 10 were mildly thrombocytopenic, whereas 7 had normal platelet counts. Severe thrombocytopenia was significantly associated with a third trimester anti–HPA-1a titer ≥ 1:32 (P = .004), but was not observed in babies of women with either transient or postnatal-only antibodies. HPA-1a alloimmunization complicates 1 in 350 unselected pregnancies, resulting in severe thrombocytopenia in 1:1,200. HPA-1a and HLA-DRB3*0101 typing combined with anti–HPA-1a titration allows selection of the majority of pregnancies at risk of severe thrombocytopenia.
Building Nanoporous Metal–Organic Frameworks “Armor” on Fibers for High-Performance Composite Materials (2017)

The nanoporous metal-organic frameworks (MOFs) "armor" is in situ intergrown onto the surfaces of carbon fibers (CFs) by nitric acid oxidization to supply nucleation sites and serves as a novel interfacial linker between the fiber and polymer matrix and a smart cushion to release interior and exterior applied forces. Simultaneous enhancements of the interfacial and interlaminar shear strength as well as the tensile strength of CFs were achieved. With the aid of an ultrasonic "cleaning" process, the optimized surface energy and tensile strength of CFs with a MOF "armor" are 83.79 mN m<sup>-1</sup> and 5.09 GPa, for an increase of 102% and 11.6%, respectively. Our work finds that the template-induced nucleation of 3D MOF onto 1D fibers is a general and promising approach toward advanced composite materials for diverse applications to meet scientific and technical demands.
Investigation of HBT layout impact on f<inf>T</inf> doubler performance for 90nm SiGe HBTs (2014)

Peak f <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</inf> of 660GHz is reported for HBT f <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</inf> doubler designs in IBM 90nm SiGe BiCMOS technology 9HP. This high performance f <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</inf> doubler utilizes a longer HBT for output stage compared to the input stage HBT (length ratio 2:1) resulting in improved transconductance and lower thermal resistance. The impact of HBT layout on the circuit performance and trade-off between thermal resistance and f <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</inf> is also investigated. f <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</inf> doubler circuit can be used as a single transistor in several circuit applications like A/D converters and broadband circuits where higher performance is desired.
Investigation of formation of nitrogen compounds in coal combustion. Final report (1983)

This is the final report on DOE contract number DE-AC21-80MC14061. It concerns the formation of nitrogen oxide from fuel-bound nitrogen during coal combustion. The work reported was divided into three tasks. They addressed problems of time-resolving pyrolysis rates of coal under simulated combustion conditions, the combustion of the tar that results from such pyrolysis, and theoretical modeling of the pyrolysis process. In all of these tasks, special attention was devoted to the fate of coal nitrogen. The first two tasks were performed by Exxon Research and Engineering Company. 49 references.
Beneficial Effect ofortho-Methoxy Groups in the Asymmetric Ring Opening ofmeso Epoxides with Silicon Tetrachloride Catalyzed by Chiralortho-Methoxyphenyldiazaphosphonamide Lewis Bases (2000)

Enantiomerenangereicherte Chlorhydrine sind durch Desymmetrisierung aus meso-Epoxiden zugänglich. Chirale Arylphosphonsäureamide wie 1 katalysieren die Ringöffnung der Epoxide durch SiCl4 zu den entsprechenden Chlorhydrinen in guten Ausbeuten (bis zu 95%) und Enantiomerenüberschüssen (bis zu >99% ee).
ChemInform Abstract: Topological Organic Chemistry. Part 5. Graph Theory, Matrix Hafnians and Pfaffians, and Topological Indices of Alkanes. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Analysis of Perforin Assembly by Quartz Crystal Microbalance Reveals a Role for Cholesterol and Calcium-independent Membrane Binding (2015)

Perforin is an essential component in the cytotoxic lymphocyte-mediated cell death pathway. The traditional view holds that perforin monomers assemble into pores in the target cell membrane via a calcium-dependent process and facilitate translocation of cytotoxic proteases into the cytoplasm to induce apoptosis. Although many studies have examined the structure and role of perforin, the mechanics of pore assembly and granzyme delivery remain unclear. Here we have employed quartz crystal microbalance with dissipation monitoring (QCM-D) to investigate binding and assembly of perforin on lipid membranes, and show that perforin monomers bind to the membrane in a cooperative manner. We also found that cholesterol influences perforin binding and activity on intact cells and model membranes. Finally, contrary to current thinking, perforin efficiently binds membranes in the absence of calcium. When calcium is added to perforin already on the membrane, the QCM-D response changes significantly, indicating that perforin becomes membranolytic only after calcium binding.
Structure and Function of an Aromatic Ensemble That Restricts the Dynamics of the Hydrophobic Core of a Designed Helix-Loop-Helix Dimer (1997)

GTD-43, a polypeptide with 43 amino acid residues, has been designed to fold into a hairpin helix-loop-helix motif that can dimerize to form a four-helix bundle. The mean residue ellipticity is −21000 deg cm2 dmol-1, and the magnitude is independent of pH in the interval of 2.4−4.6. The chemical shift dispersion of the amide proton and methyl regions of the 1H NMR spectrum is only slightly less than that of Interleukin-4, a naturally occurring four-helix bundle, and much larger than those reported for molten globule structures. The temperature dependence of the 1H NMR spectrum shows that GTD-43 is in slow exchange on the NMR time scale and that the temperature interval for thermal denaturation is narrow. These spectroscopic probes show that GTD-43 exhibits remarkable structural characteristics for a de novo designed four-helix bundle, and the structural basis for the observed properties has now been determined. GTD-43 folds into a symmetric dimer, and the secondary structure as well as the formation of the hairpin helix-loop-helix motif has been established from NMR spectroscopy. GTD-43 has been designed to form complementary hydrophobic interfaces between the helices, and an aromatic ensemble consisting of Phe10, Trp13, and Phe34 has been incorporated in the interior of the hydrophobic core to restrict the dynamics and give rise to a well-defined tertiary structure. The interaction between the residues in the aromatic ensemble has been established from the observation of a number of long-range NOEs. The formation of a well-defined tertiary structure in the region of the Phe-Trp-Phe residues has been demonstrated by slow amide proton exchange rates and Trp fluorescence. This is the first report of a designed hydrophobic core in a four-helix bundle based on aromatic residues, and the structural property of GTD-43 suggests that the design principle is of general applicability in the de novo design of proteins.
IMMUNOPATHOGENESIS OF CONJUNCTIVAL HISTOPATHOLOGIC ALTERATIONS IN NON-SJÖGREN'S KERATOCONJUNCTIVITIS SICCA. (2000)

Third International Conference on the Lacrimal Gland, Tear Film and Dry Eye Syndromes: Basic Science and Clinical Relevance: Maui, Hawaii; November 15-18, 2000: Abstracts
Gastrointestinal hormones and the regulation of β‐cell mass (2010)

Type 2 diabetes occurs due to a relative deficit in β-cell mass or function. Glucagon-like peptide 1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), cholecystokinin (CCK), and gastrin are gastrointestinal hormones that are secreted in response to nutrient intake, regulating digestion, insulin secretion, satiety, and β-cell mass. In this review, we focus upon β-cell mass regulation. β-cell mass expands through β-cell proliferation and islet neogenesis; β-cell mass is lost via apoptosis. GLP-1 and GIP are well-studied gastrointestinal hormones and influence β-cell proliferation, apoptosis, and islet neogenesis. CCK regulates β-cell apoptosis and mitogenesis, and gastrin stimulates islet neogenesis. GLP-1 and GIP bind to G protein-coupled receptors and regulate β-cell mass via multiple signaling pathways. The protein kinase A pathway is central to this process because it directly regulates proliferative and anti-apoptotic genes and transactivates several signaling cascades, including Akt and mitogen-activated protein kinases. However, the signaling pathways downstream of G protein-coupled CCK receptors that influence β-cell mass remain unidentified. Gastrointestinal hormones integrate nutrient signals from the gut to the β-cell, regulating insulin secretion and β-cell mass adaptation.
Impact of Maintenance Therapy for Patients with Non-small Cell Lung Cancer in a Real-world Setting (2017)

Maintenance therapy for patients with advanced NSCLC might be an appropriate strategy to maximize the chance of receiving more active therapy.
Compliant Kinematic Couplings for Use in Manufacturing and Assembly (1998)

Abstract Repeatable positioning and rigid coupling are critical to manufacturing processes. Traditionally, pin joints and elastic averaging methods have been used to create reasonably repeatable and stiff joints. However, for repeatability below 200 μinches (5μm) these methods become expensive to manufacture. Less often used, are kinematic couplings which can attain sub-micron level repeatability, but have limited stiffness and don’t allow the mating of surfaces (as required in casting.) In this paper, a new type of coupling, a compliant kinematic coupling, which combines the desirable characteristics of many methods is presented. The result is a coupling with the stiffness characteristics of elastically averaged couplings, good repeatability, and the ability to allow surfaces to mate. Repeatability tests in low cost versions of these couplings show radial repeatability of 200μinch (5μm) and angular repeatability of 57 μradians. This coupling method can be used in casting, assembly, fixturing, sheet metal forming, and other processes.
Transcatheter left ventriculoplasty (2023)

Despite significant advances in pharmacological, electrophysiological and valve therapies for heart failure with reduced ejection fraction (HFrEF), the associated morbidity, mortality and healthcare costs remain high. With a constantly growing heart failure population, the existing treatment gap between current and advanced heart failure therapies (e.g., left ventricular [LV] assist devices, heart transplantation) reflects a large unmet need, calling for novel therapeutic approaches. Left ventricular remodelling and dilatation, with or without scar formation, is the hallmark of cardiomyopathy and is associated with poor prognosis. In the era of exciting advances in structural heart interventions, the advent of minimally invasive, device-based therapies directly targeting the LV geometry and promoting physical reverse remodelling has created a new frontier in the battle against heart failure. Interventional heart failure therapy is a rapidly emerging field, encompassing structural heart and minimally invasive hybrid procedures, with two left ventriculoplasty devices currently under investigation in pivotal clinical trials in the US. This review addresses the rationale for left ventriculoplasty, presents the prior surgical and percutaneous attempts in the field, provides an overview of the novel transcatheter left ventriculoplasty devices and their respective trials, and highlights potential challenges associated with establishing such device-based therapies in our armamentarium against heart failure.
Anomalous Expansion of Attractively Interacting Fermionic Atoms in an Optical Lattice (2010)

The interplay of thermodynamics and quantum correlations can give rise to counterintuitive phenomena in many-body systems. We report on an isentropic effect in a spin mixture of attractively interacting fermionic atoms in an optical lattice. As we adiabatically increase the attraction between the atoms, we observe that the gas expands instead of contracting. This unexpected behavior demonstrates the crucial role of the lattice potential in the thermodynamics of the fermionic Hubbard model.
Supplementary Materials and Tables 1-3 from Chromosomal Instability Correlates with Genome-wide DNA Demethylation in Human Primary Colorectal Cancers (2023)

Supplementary Materials and Tables 1-3 from Chromosomal Instability Correlates with Genome-wide DNA Demethylation in Human Primary Colorectal Cancers
Multiplicative Surrogate Standard Deviation: A Group Metric for the Glycemic Variability of Individual Hospitalized Patients (2013)

By using the MSSD with its MSD, groups can be characterized and compared according to glycemic variability of individual patient members.
Dethiosulfatarculus sandiegensis gen. nov., sp. nov., isolated from a methanogenic paraffin-degrading enrichment culture and emended description of the family Desulfarculaceae (2015)

A mesophilic deltaproteobacterium, designated strain SPR<sup>T</sup>, was isolated from a methanogenic consortium capable of degrading long-chain paraffins. Cells were motile, vibrio-shaped, and occurred singly, in pairs or in clusters. Strain SPR<sup>T</sup> did not metabolize hydrocarbons but grew fermentatively on pyruvate and oxaloacetate and autotrophically with H<sub>2</sub> and CO<sub>2</sub>. Thiosulfate served as a terminal electron acceptor, but sulfate or sulfite did not. The organism required at least 10 g NaCl l<sup>- 1</sup> and a small amount of yeast extract (0.001%) for growth. Optimal growth was observed between 30 and 37 °C and a pH range from 6.0 to 7.2. The DNA G+C content of SPR<sup>T</sup>'s genome was 52.02 mol%. Based on 16S rRNA gene sequence analysis, strain SPR<sup>T</sup> was distinct from previously described <i>Deltaproteobacteria</i>, exhibiting the closest affiliation to <i>Desulfarculus baarsii</i> DSM 2075<sup>T</sup> and <i>Desulfocarbo indianensis</i> SCBM<sup>T</sup>, with only 91% similarity between their respective 16S gene sequences. <i>In silico</i> genome comparison supported the distinctiveness between strain SPR<sup>T</sup> and both <i>Desulfocarbo indianensis</i> SCBM<sup>T</sup> and <i>Desulfarculus baarsii</i> DSM 2075<sup>T</sup>. Based on physiological differences, as well as phylogenetic and genomic comparisons, we propose to classify SPR<sup>T</sup> as the type strain ( = DSM 100305<sup>T</sup> = JCM 30857<sup>T</sup>) of a novel species of a new genus with the name <i>Dethiosulfatarculus sandiegensis</i> gen. nov., sp. nov.
The performance of a multiversion access method (1990)

The Time-Split B-tree is an integrated index structure for a versioned timestamped database. It gradually migrates data from a current database to an historical database, records migrating when nodes split. Records valid at the split time are placed in both an historical node and a current node. This implies some redundancy. Using both analysis and simulation, we characterise the amount of redundancy, the space utilization, and the record addition (insert or update) performance for a spectrum of different rates of insertion versus update. Three splitting policies are studied which alter the conditions under which either time splits or key space splits are performed.
Raman signatures of TNT in contact with sand particles (2005)

Landmines have become a problem and a daily risk in approximately 70 countries. There exists a broad variety of types of mines in which trinitrotoluene (TNT) is mostly used as the main explosive charge. TNT has a number of specific properties that make it a nearly ideal explosive for military applications. There are several methods currently used to detect buried landmines. The goal of this work is develop new methods for detecting TNT in contact with soil and sand. Raman microscopy is used to provide information about identity, composition, molecular orientation or crystal formation in very small samples or small heterogeneities in large samples. The possible interactions of the energetic material with sand particles have been studied by quantitative vibrational spectroscopy. Ambient conditions that may affect the spectroscopic signature of the explosive in contact with soil were also studied. Among the parameters investigated were: Sand-TNT mass ratio, temperature, pH of soil, incidence of UV light and water content. The characteristic bands of TNT are not significantly shifted, but rather appear constant with respect of the characteristic band of Si-O in sand (~464 cm<sup>-1</sup>).
A combined simulation/optimization approach to process plant design (1992)

Article A combined simulation/optimization approach to process plant design Share on Authors: J. F. Faccenda View Profile , R. F. Tenga View Profile Authors Info & Claims WSC '92: Proceedings of the 24th conference on Winter simulationDecember 1992 Pages 1256–1261https://doi.org/10.1145/167293.167908Published:01 December 1992 4citation301DownloadsMetricsTotal Citations4Total Downloads301Last 12 Months4Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Infliximab Versus Adalimumab in the Treatment of Refractory Inflammatory Uveitis: A Multicenter Study From the French Uveitis Network (2016)

Anti-TNF treatment is highly effective in refractory inflammatory uveitis. BD is associated with increased odds of response. IFX and ADA appear to be equivalent in terms of efficacy.
Inactivation of the Tumor Suppressor Gene on 11q13 in Brothers with Familial Acrogigantism without Multiple Endocrine Neoplasia Type 11 (1997)

Two of three brothers (the second and third brothers) and their uncle (their mother's brother) presented acrogigantism without multiple endocrine neoplasia type 1 (MEN 1). An invasive macroadenoma was found in the second brother, and it was histologically confirmed as a sparsely granulated GH cell adenoma. Two distinct microadenomas were found in the third brother, and these were histologically diagnosed as a mixed GH cell and PRL cell adenoma and a sparsely granulated GH cell adenoma, respectively. The loss of heterozygosity (LOH) was analyzed in two adenomas (GH cell adenoma from the second brother and a mixed GH cell and PRL cell adenoma from the third brother) by determining microsatellite polymorphisms of DNAs from tumors and patients' leukocytes. The LOH was found on the chromosome 11q13, whereas LOH was not detected on 1p31-36, 2p, 3p, 4, 5, 6p, 7, 8, 9p21-22, 12p, and 19q13 in both pituitary adenomas examined. The haplotype analysis showed that the same haplotype on 11q13 was found in their mother and the unaffected first brother as well as in the affected uncle and two brothers. The deleted alleles on chromosome 11q13 in the tumors of two affected brothers were, however, restricted to those transmitted from their unaffected father. These data suggest that inactivation of the MEN 1 gene or other tumor suppressor genes on chromosome 11q13 plays an important role for the development of our familial acrogigantism without MEN 1.
Alterations in Acylcarnitines, Amines, and Lipids Inform about Mechanism of Action of Citalopram/Escitalopram in Major Depression (2020)

Abstract Selective serotonin reuptake inhibitors (SSRIs) are the first-line treatment for major depressive disorder (MDD), yet their mechanisms of action are not fully understood and their therapeutic benefit varies among individuals. We used a targeted metabolomics approach utilizing a panel of 180 metabolites to gain insights into mechanisms of action and response to citalopram/escitalopram. Plasma samples from 136 participants with MDD enrolled into the Mayo Pharmacogenomics Research Network Antidepressant Medication Pharmacogenomic Study (PGRN-AMPS) were profiled at baseline and after 8 weeks of treatment. After treatment, we saw increased levels of short-chain acylcarnitines and decreased levels of medium- and long-chain acylcarnitines, suggesting an SSRI effect on β-oxidation and mitochondrial function. Amines – including arginine, proline, and methionine-sulfoxide – were upregulated while serotonin and sarcosine were downregulated, suggesting an SSRI effect on urea cycle, one-carbon metabolism and serotonin uptake. Eighteen lipids within the phosphatidylcholine (PC aa and ae) classes were upregulated. Changes in several lipid and amine levels correlated with changes in 17-item Hamilton Rating Scale for Depression scores (HRSD 17 ). Differences in metabolic profiles at baseline and post-treatment were noted between participants who remitted (HRSD 17 ≤7) and those who gained no meaningful benefits (&lt;30% reduction in HRSD 17 ). Remitters exhibited a) higher baseline levels of C3, C5, alpha-aminoadipic acid, sarcosine and serotonin; and b) higher week-8 levels of PC aa C34:1, PC aa C34:2, PC aa C36:2 and PC aa C36:4. These findings suggest that mitochondrial energetics – including acylcarnitine metabolism, transport and its link to β-oxidation – and lipid membrane remodeling may play roles in SSRI treatment response.
Separation of primaries and multiples using VD-seislet frame (2014)

Summary Separation of primary and multiple reflections is a key step for successful imaging of multiples. The seislet transform is a wavelet-like transform that analyzes seismic data by following variable slopes of seismic events across different scales and provides a multiscale orthogonal basis for seismic data. We adopt a new velocity-dependent (VD) formulation of the seislet transform, where the normal moveout equation serves as a bridge between local slope patterns and conventional moveout parameters in the CMP domain. Different slope patterns for primaries and pegleg multiples further constitute VD-seislet frame to separate primaries from multiples. Synthetic and field data tests show the effectiveness of VD-seislet frame for separation of primaries and pegleg multiples of different orders.