gebhart/patrepeval huggingface dataset:
Effets neurotoxiques du plomb chez l'enfant : aspects biologiques et épidémiologiques (2001)

Le plomb est un metal utilise depuis l'Antiquite et ses effets nefastes sur la sante sont connus depuis plusieurs siecles [1]. L'introduction du plomb dans certaines peintures puis dans l'essence a eu pour consequence une large diffusion dans l'environnement. Les poussieres et les peintures des habitats anciens et degrades, l'eau de boisson et, a un degre moindre, l'alimentation, sont des sources remanentes d'exposition des populations au plomb. Le plomb ingere ou inhale est stocke dans les tissus mous comme le cerveau, et dans les tissus calcifies comme les dents et les os. L'absorption est plus grande chez les enfants que chez les adultes. La toxicite neurologique du plomb est particulierement preoccupante chez l'enfant, du fait de la vulnerabilite du systeme nerveux en developpement [2]. En cas d'exposition aigue elevee, on observe une encephalopathie chez l'adulte ou l'enfant. Chez l'enfant, elle apparait pour des niveaux au-dessus de 800-1000 mug/l, dus a l'ingestion de debris de peinture au plomb. Les signes cliniques typiques de cette encephalopathie sont coma, ataxie, convulsions, apathie, incoordination, vomissements, perte de conscience, perte des competences acquises, paresies, troubles sensoriels [3]. La symptomatologie d'une intoxication chronique est peu specifique voire meme absente. On peut observer des difficultes scolaires, un retard psychomoteur, des troubles du sommeil. L'exposition de l'enfant au plomb peut etre pre- ou postnatale. Durant la grossesse, on observe une mobilisation du plomb contenu dans les os maternels, liee aux besoins augmentes en calcium. Ainsi, l'exposition du foetus n'est pas seulement determinee par l'exposition actuelle de la mere, mais aussi par son exposition ancienne. En postnatal, un comportement de Pica chez les jeunes enfants est le principal facteur de risque d'intoxication aigue par le plomb. Au cours des deux dernieres decennies, plusieurs etudes epidemiologiques ont tente de mettre en evidence les consequences d'une exposition a faible dose de plomb (en dessous de 400 mug/l) sur le systeme nerveux central de l'enfant, en evaluant le retentissement sur le developpement psychomoteur ou intellectuel. Dans cet article seront presentees une analyse des etudes anatomocliniques et cellulaires des effets du plomb au cours du developpement cerebral, les etudes comportementales chez l'animal, et les principales etudes epidemiologiques ayant analyse les effets du plomb a faible dose sur les fonctions cognitives chez l'enfant.
Hybrid Steering Logic for Single-Gimbal Control Moment Gyroscopes (2010)

The development of a hybrid steering logic that maintains attitude tracking precision while avoiding hyperbolic internal singularities or escaping elliptic singularities inherent to single-gimbal control moment gyroscopes is discussed. The hybrid steering logic enables null motion and limits torque error when approaching a hyperbolic internal singularity, or it adds torque error and limits null motion when approaching an elliptic internal or external singularity. The hybrid-steering-logic algorithm accomplishes these tasks through the definitions of novel singularity metrics that transition continuously from local-gradient to pseudoinverse methods when moving from hyperbolic to elliptic singularities. Analysis and simulations are presented to demonstrate the performance of the hybrid steering logic as compared with the two legacy methods. The development and results are applied to a four-single-gimbal-control-moment-gyroscope pyramid arrangement with a skew angle of θ = 54.74 deg.
<title>Structuring of dielectric and metallic materials with ultrashort laser pulses between 20 fs and 3 ps</title> (1997)

Laser-micromachining of barium aluminum borosilicate glass, fused silica and stainless steel has been extended down to a pulse duration of 20 fs generated by a Ti:sapphire laser system at a wavelength of 0.8 micrometer. A systematic study shows that, below 100 fs, an enhanced precision and a substantial decrease of the ablation threshold fluence in comparison to pulse laser processing with pulses in the picosecond and nanosecond range could be achieved. The physical mechanism and the technical relevance of this novel microtechnology is discussed.
Factors associated with a delay in diagnosis of recurrent prostate cancer after radical prostatectomy. (2011)

208 Background: Salvage radiation therapy has an improved chance of increasing prostate cancer survival if it is administered at the earliest sign of recurrence, when prostate-specific antigen (PSA) is low. We identified factors associated with delay in diagnosis of recurrent prostate cancer after prostatectomy. Methods: We analyzed 375 men with PSA recurrence after prostatectomy enrolled in the Comprehensive, Observational, Multicenter, Prostate Adenocarcinoma Registry. Delay in diagnosis was defined as the time, in months, between recorded PSA greater than or equal to 0.2 ng/ml and enrollment in the registry. Multivariable regression analysis was used to identify sociodemographic and clinical factors associated with diagnosis delay. Diagnosis delay was dichotomized at the median (10 months) for the analysis. Results: At enrollment the median age was 70 years, median time since prostatectomy was 71 months, and median PSA was 0.7 ng/ml. On multivariable analysis, older men (p=0.043), men with greater length of time since surgery (p&lt;0.001), and men who contemplated delaying their PSA test (p=0.004) were more likely to have a delay in diagnosis of PSA recurrence. Men with Gleason 8 or higher disease at initial cancer diagnosis were less likely to have a delay (p=0.028). Conclusions: Older men, men with greater time interval since prostatectomy, and men who contemplate delaying their PSA test are more likely to have a delay in diagnosis of recurrent prostate cancer. Since early salvage radiation therapy may be curative, physicians should encourage PSA vigilance and early referral if a rising PSA is noted among men with these characteristics. [Table: see text]
Algorithm for Calculation of Wall Thickness for Hollow Turbine Blade Wax-patterns with Inscribed Circle Chord Length (2011)

To realize the high speed and low cost measurement of the wall thickness of the wax pattern of a turbine blade,a novel wall thickness calculation method is proposed based on the inscribed circle chord length between the inside and outside contour lines of the wax pattern wall.First,the optical scanning data registration of the wax-pattern and the ceramic core is studied,and the contour lines are extracted from the registration model.Then,two different computing models for the inscribed circle chord length of the contour lines are built.Finally,a sample application is presented for demonstration by comparing the method in this article with the computer tomography(CT) measured data.The result shows that the wall thickness calculated by the inscribed circle chord length method agrees well with the CT measured data.
ChemInform Abstract: β‐D‐ARABINOFURAN(1′,2′:4,5)OXAZOLO‐1,3,5‐TRIAZINE‐5‐N‐METHYL‐4,6‐DIONE AND ANALOGUES, UNUSUALLY SPECIFIC IMMNUNOSUPPRESSIVE AGENTS (1978)

Abstract Das aus Arabinose und Cyanamid erhaltene Kondensat liefert nach Silylierung die Ether (IIßIa) und (IIIb), die mit NaH und Methylisothjocyanat zu den beiden isomeren Addukten (I) und (II) oder mit NaH und Methylisocyanat zum Harnstoff (IV) reagieren.
Clean room design considerations for deep-underground science and engineering laboratories (2007)

This paper presents the factors that affect the clean room shielding design at the deep-underground science and engineering laboratory (DUSEL), for enhancing detection of weakly interacting massive particles (WIMP), neutrino or double beta decay signals. The goal of the shielded clean room is to minimize the neutron and gamma-ray background and spurious signals, including secondary particles generated within shielding materials, permitting increased probability of detection of signals arising from WIMP and other particles of interest. Various arrangement options of shielded blocks made of paraffin and lead are examined to reduce the background from intrinsic uranium/thorium trace sources and high energy charged cosmic particles that interact with passive shielding material. A new shield block material is proposed and compared with other ordinary shield block arrangements currently used in detector passive shielding designs.
ROTATIONAL INTENSITIES IN FLUORESCENCE FROM SELECTIVELY EXCITED $S_{2}$ (1975)

This work was supported by the National Science Foundation.
Blood Transfusion After Primary Total Hip Arthroplasty: National Trends and Perioperative Outcomes. (2018)

The purpose of this study was to quantify the changes in transfusion rates, both allogeneic blood transfusion (ALBT) and autogenic blood transfusion (ATBT) on a national scale, and determine patient factors associated with transfusions. The National Hospital Discharge Survey was evaluated between 2001 and 2010 for primary total hip arthroplasty (THA) patients and categorized on the basis of transfusion necessity, type, and comorbidity burden. A logistic regression comparison of ALBT, ATBT, and nontransfused patients was performed with respect to patient demographics and in-hospital complications. The proportion of patients requiring any transfusion decreased from an average rate of 22.8% between 2001 and 2005 to 21.2% between 2006 and 2010 (p = .01). ATBT rates decreased (r = -.99) from 11.0% in 2001 to 2.8% in 2010. ALBT rates increased (r = .66) from 14% in 2001 to 16.6% in 2010. The number of patients requiring a blood transfusion after THA decreased in the United States with a trend shifting from ATBT to ALBT. (Journal of Surgical Orthopaedic Advances 26(4):216-222, 2017).
Oxidative Stress and Increase of Vascular Endothelial Growth Factor in Plasma of Patients with Peripheral Arterial Occlusive Disease (2001)

Oxidative Stress and Increase of Vascular Endothelial Growth Factor in Plasma of Patients with Peripheral Arterial Occlusive Disease -
A Mixed-Signal Approach for Tuning Continuous-Time Low-Pass Filters (2004)

A mixed-signal approach for tuning the bandwidth of continuous-time low-pass filters is presented. The tuning loop uses common circuit blocks (a data converter and digital filters). Simulation results are presented for a number of filters, and measured results are presented for tuning second-order and fourth-order filters.
Relationship of insulin‐like growth factor‐I, insulin‐like growth factor binding protein‐3, insulin, growth hormone in cord blood and maternal factors with birth height and birthweight (2000)

Our results suggest that fetal growth depends on fetal levels of IGF-I and IGFBP-3 and maternal factors, not on insulin or GH. Levels of IGF-I and IGFBP-3 may not be regulated by insulin alone, but by the complex interactions between several factors, such as insulin, GH and maternal factors.
BCG hydrogel promotes CTSS-mediated antigen processing and presentation, thereby suppressing metastasis and prolonging survival in melanoma (2022)

These findings provide mechanistic insights as well as rationale for the clinical translation of BCG hydrogel as cancer immunotherapy to overcome the current limitations of immunotherapies for the treatment of patients with melanoma.
Proton Magnetic Resonance of Amino Acids, Peptides and their Metal Complexes (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProton Magnetic Resonance of Amino Acids, Peptides and their Metal ComplexesNorman C. Li, Robert L. Scruggs, and Edwin D. BeckerCite this: J. Am. Chem. Soc. 1962, 84, 24, 4650–4654Publication Date (Print):December 1, 1962Publication History Published online1 May 2002Published inissue 1 December 1962https://pubs.acs.org/doi/10.1021/ja00883a007https://doi.org/10.1021/ja00883a007research-articleACS PublicationsRequest reuse permissionsArticle Views107Altmetric-Citations50LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Properties of the Na+-K+ pump in human red cells with increased number of pump sites. (1987)

We studied the Na+/K+ pump in red cells from an obese human subject (MAJ) in which the number of pumps/cell was 10-20 times higher than normal. Through measurements of the kinetic properties of several modes of operation of the Na+/K+ pump we determined that the pumps in MAJ cells are kinetically normal. In the presence of adequate metabolic substrate the maximum rates of Na+ pumping and lactate production saturated at 60 and 12 nmol/1 cell per h, respectively. Under physiological conditions pump and "leak" Na+ fluxes were similar in MAJ and normal cells. Since internal Na+ was lower in MAJ than in normal cells (Nai+ approximately 2 and 8 mmol/1 cell, respectively), we conclude that the reduction in cell Na+ allows the Na+/K+ pump in MAJ cells to operate at lower fraction of maximum capacity and to compensate for the increased number of pumps.
Accurate Reconstruction of the Temporal Order of Mutations in Neoplastic Progression (2011)

The canonical route from normal tissue to cancer occurs through sequential acquisition of somatic mutations. Many studies have constructed a linear genetic model for tumorigenesis using the genetic alterations associated with samples at different stages of neoplastic progression from cross-sectional data. The common interpretation of these models is that they reflect the temporal order within any given tumor. Linear genetic methods implicitly neglect genetic heterogeneity within a neoplasm; each neoplasm is assumed to consist of one dominant clone. We modeled neoplastic progression of colorectal cancer using an agent-based model of a colon crypt and found clonal heterogeneity within our simulated neoplasms, as observed in vivo. Just 7.3% of cells within neoplasms acquired mutations in the same order as the linear model. In 41% of the simulated neoplasms, no cells acquired mutations in the same order as the linear model. We obtained similarly poor results when comparing the temporal order with oncogenetic tree models inferred from cross-sectional data. However, when we reconstructed the cell lineage of mutations within a neoplasm using several biopsies, we found that 99.7% cells within neoplasms acquired their mutations in an order consistent with the cell lineage mutational order. Thus, we find that using cross-sectional data to infer mutational order is misleading, whereas phylogenetic methods based on sampling intratumor heterogeneity accurately reconstructs the evolutionary history of tumors. In addition, we find evidence that disruption of differentiation is likely the first lesion in progression for most cancers and should be one of the few regularities of neoplastic progression across cancers.
An interconnect channel design methodology for high performance integrated circuits (2004)

On-chip communication is becoming a bottleneck for high performance designs. Conventional interconnect design methodology does not account for architectures and/or communication schemes that require storage buffers (first-in-first-out queues or FIFOs) in the interconnect channel. For example, FIFOs and flow-control are needed for Network-on-Chip, high performance ASICs and multiple clock domain designs. These IC implementation architectures require an efficient methodology to determine the size of the FIFOs in the channel since the FIFO sizes affect system performance. In this work we devised a methodology to size the FIFOs in an interconnect channel containing one or more FIFOs connected in series. We show that the sizing of the FIFOs in the channel is a function of system parameters such as data production rate and consumption rate, data burstiness, number of channel stages etc. and we also quantify their effect on performance. For a single clock design, we have developed an efficient algorithm which reduces the search space for the optimal sizing of the FIFOs in the channel.
Impact of oil composition on formation and stability of emulsions produced by spontaneous emulsification (2017)

In this study, triglycerides of different chain lengths were mixed with paraffin oil, and their effectiveness in forming emulsions produced by spontaneous emulsification upon the addition of water was investigated. The emulsion droplet size exhibited a similar trend as a function of the triglyceride/paraffin oil composition for medium-chain (MCTs) (C8–C10) and long-chain (C18) triglycerides (LCTs). However, emulsions formulated with MCTs and LCTs have a much smaller droplet size (about 50 nm) than emulsions based upon short-chain (C4) triglycerides (SCTs). The addition of SCTs resulted in droplet sizes around 800 nm and the emulsions formed were very unstable. The droplet size, polydispersity index, zeta potential, and emulsion stability of these systems will be described as a function of the oil phase composition.
Diferencias en las tendencias de mortalidad por cáncer colorrectal entre Bogotá y Colombia entre 1985 y 2004 : análisis edad-periodo-cohorte (2009)

El cancer de colon y recto en Colombia se ubica como la quinta causa de mortalidad atribuible a cancer. Se realiza un analisis de tendencias de mortalidad por cancer colorrectal entre 1985 y 2004, utilizando un modelo estadistico de edad-periodo-cohorte.
Se identificaron los certificados de defuncion con registro de este diagnostico como causa basica de muerte, en las bases de datos de defuncion del DANE entre 1985 y 2004. Se agruparon las muertes por grupos de edad y por periodo de defuncion de cinco anos. Se hizo un analisis de tendencias de mortalidad utilizando un modelo estadistico de Edad  Periodo  Cohorte (EPC)
Resultados. Los modelos de EDAD + COHORTE se ajustaron a la explicacion del comportamiento de la mortalidad por cancer de colon y recto en hombres tanto a nivel nacional (deviance 24,44; p 0,169 AIC 8,72) y en la ciudad de Bogota y entre las mujeres a nivel nacional; mientras que entre las mujeres a nivel de Bogota, el comportamiento de la mortalidad por cancer de colorrectal es explicado unicamente por efecto de la edad (deviance 36,1; p 0,2; AIC 6,92)
Discusion. El efecto que se observa mas claramente es el efecto de cohorte, el cual es evidente en las cohortes de mediados del siglo XX, lo cual podria corresponder a los cambios en el estilo de vida. Se recomienda hacer estudios analiticos que expliquen de mejor forma el efecto de cohorte y aclaren el hecho de que dicho efecto no se presente entre las mujeres de Bogota.
Towards the next generation of 3D content creation (2004)

In this paper we present a novel integrated 3D editing environment that combines recent advantages in various fields of computer graphics, such as shape modelling, video-based Human Computer Interaction, force feedback and VR fine-manipulation techniques. This integration allows us to create a new compelling form of 3D object creation and manipulation preserving the metaphors designers, artists and painters have accustomed to during their day to day practice. Our system comprises a novel augmented reality workbench and enables users to simultaneously perform natural fine pose determination of the edited object with one hand and model or paint the object with the other hand. The hardware setup features a non-intrusive, video-based hand tracking subsystem, see-through glasses and a 3D 6-degree of freedom input device. The possibilities delivered by our AR workbench enable us to implement traditional and recent editing metaphors in an immersive and fully three-dimensional environment, as well as to develop novel approaches to 3D object interaction.
Institutional Board Review for Clinical Investigations on Inflammatory Bowel Diseases: A Single-Center Study (2015)

In Korea, rare diseases such as IBD require more information for the IRB process due to their distinct characteristics. IBD researchers should develop research protocols more carefully and make their research as subject-friendly as possible.
Hypoxia‐driven proliferation of human pulmonary artery fibroblasts: cross‐talk between HIF‐1α and an autocrine angiotensin system (2005)

Pulmonary artery adventitial fibroblasts (FBPA) may play a central role in lung vascular remodeling under conditions of hypoxia and inflammation, the result being pulmonary hypertension and cor pulmonale. In cultured human FBPA, both angiotensin II (Ang II) and hypoxia promoted cell cycle progression and cell proliferation and suppressed apoptosis. These effects were further enhanced when both stimuli were applied simultaneously. Hypoxia elevated the expression of hypoxia-inducible factor 1alpha (HIF-1alpha) and increased the expression of genes regulated by the hypoxia-responsive element (HRE). Up-regulation of both angiotensin-converting enzyme (ACE) and Ang II receptor type 1 (AT1) was also observed. Exogenous Ang II further increased HIF/HRE-dependent signaling in FBPA, whereas suppression of the autocrine ACE-Ang II-AT1 loop with inhibitors of ACE, AT1, and phosphatidylinositol 3-kinase (PI3K) reduced the proliferative response to both hypoxia and exogenous Ang II. Overexpression of HIF-1alpha by transient transfection caused the same proliferative effect and up-regulation of AT1 expression that were observed under hypoxic conditions. In contrast, small interfering RNA targeting HIF-1alpha inhibited hypoxia-induced ACE and AT1 expression. Our studies indicate that the ACE-Ang II-AT1 system serves as a positive feedback loop and fosters FBPA proliferation under hypoxic conditions, with the PI3K-HIF-HRE axis as the central effector pathway. This pathway may thus facilitate vascular remodeling under hypoxic conditions.
Demonstration of Monitoring and Data Analytics-triggered reconfiguration in partially disaggregated optical networks (2020)

We demonstrate a novel agent for optical disaggregated optical networks. When the Monitoring and Data Analytics detects a degradation, it recommends the SDN controller to trigger a network reconfiguration computed by a novel planning tool.
Enrichment of poultry manure with biomass ash to produce organomineral fertiliser (2018)

In this study, the contribution of hot biomass ash to enrichment of the mineral content and to reducing the moisture content of broiler poultry manure was investigated. For this purpose, the mixtures have been prepared by adding biomass ash at varying rates (10%, 20%, 30%, 40% and 50%) and at different temperatures (100C, 150C, 200C and 250C) according to the dry matter content (74.77%) of the poultry manure. The results showed that incorporation of biomass ash into poultry manure at 50% at 250C reduced the moisture content from 25.23% to 9.82%. Regarding the maximum N in the final product, the ideal temperature of biomass ash has been obtained at 150C. The highest nutrient contents were obtained at 50% biomass ash incorporation. The highest dose of biomass ash application had significantly increased nutrients, such as Ca (19.34%), K (4.03%), Fe (1,545 mg/kg), Mn (812 mg/kg) and Zn (479 mg/kg) in the final organomineral fertiliser formulation. Overall, it was concluded that the addition of hot biomass ash can dramatically decrease the moisture content of poultry manure and therefore provide odour and pathogen removal and increase its plant nutrient content.