gebhart/patrepeval huggingface dataset:
P1–267: The relation of depression to Alzheimer's disease is not explained by vascular risk factors and stroke (2006)

Depressive symptoms in the elderly are associated with an increased risk of Alzheimer's disease (AD). The mechanisms for this association are unclear, but may include the presence of cerebrovascular disease. We sought to determine whether the association between depressive symptoms and AD is explained by the presence of cerebrovascular risk factors and stroke. 526 elderly persons from Northern New York City without dementia at baseline were followed for a mean of 5 years. Depressive symptoms were assessed using the 17–item Hamilton Depression Rating Scale (HAM–D). Incident AD was ascertained using standard research criteria. Diabetes, hypertension, heart disease, current smoking and stroke were ascertained by self–report. Cox proportional hazards regression was used to relate HAM–D scores to incident AD. AD risk increased with increasing HAM–D scores when examined as a continuous logarithmically transformed variable (HR for one point increase = 1.4; 95% CI: 1.1,1.8) and as a categorical variable (HR for HAM–D ≥ 10 = 3.4; 95% CI=1.5,8.1; p for trend = 0.004 with HAM–D = 0 as the reference). These results were virtually unchanged after adjustment for vascular risk factors and stroke, individually, and in a composite measure, and when persons with stroke were excluded. The relation between depressive symptoms and development of AD is not explained by the presence of cerebrovascular risk factors and stroke, suggesting that mechanisms other than cerebrovascular disease account for this association.
Effect of Perfluorinated-Hexaethylene Glycol Functionalization of Gold Nanoparticles on the Enhancement of the Response of an Enzymatic Conductometric Biosensor for Urea Detection (2016)

International audience
Parathyroid hormone-related protein, an autocrine regulatory factor in alveolar epithelial cells (1996)

Alveolar epithelial cells in vivo, primary cultures of adult rat type II cells, and human A549 alveolar carcinoma cells express parathyroid hormone-related protein (PTHrP). Here we demonstrated that type II cells and A549 cells also express the PTHrP receptor and that they exhibit differentiation-related responses to the amino-terminal PTHrP fragment, PTHrP-(1-34). PTHrP receptor expression in A549 cells was shown by detection of a 0.3-kb reverse transcriptase polymerase chain reaction product formed by primers specific for PTHrP receptor. In situ hybridization studies localized the site of production of PTHrP and PTHrP receptor mRNA in rat lung cells with morphology and location typical of type II cells. Primary cultures of such type II cells also expressed PTHrP receptor mRNA. Incubation with PTHrP-(1-34) stimulated disaturated phosphatidylcholine (DSPC) synthesis in A549 cells and increased the release of newly synthesized DSPC by cultured type II cells and A549 cells. In addition, PTHrP-(1-34) increased the number of lamellar bodies per type II cell and increased their expression of alkaline phosphatase in a dose-dependent manner. Thus PTHrP-(1-34) promoted a differentiated type II cell phenotype. Since cultured type II cells, alveolar epithelial cells in vivo, and A549 cells express PTHrP and the PTHrP receptor, PTHrP-(1-34) may be an autocrine regulatory factor in type II cells and lung cancer cells.
Synthesis of Metal–Teflon AF Nanocomposites by Solution‐Phase Methods (2005)

Embedding metal and metal-oxide nanoparticles into a Teflon AF matrix using two solution-phase synthesis techniques has been developed and exemplified using silver, gold, palladium, and nickel nanoparticles. The nanocomposite materials (see Figure) exhibit greatly improved chemical stability and can find applications in optoelectronics, catalysis, and as protective coatings. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2089/2005/c0391_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Inducible Costimulatory Molecule-B7-Related Protein 1 Interactions Are Important for the Clonal Expansion and B Cell Helper Functions of Naive, Th1, and Th2 T Cells (2003)

Inducing T cell responses requires at least two distinct signals: 1) TCR engagement of MHC-peptide and 2) binding of CD28 to B7.1/2. However, the recent avalanche of newly described costimulatory molecules may represent additional signals which can modify events after the initial two-signal activation. Inducible costimulatory molecule (ICOS) is a CD28 family member expressed on T cells rapidly following activation that augments both Th1 and Th2 T cell responses and has been implicated in sustaining rather than initiating T cell responses. Although it is known that blockade of ICOS-B7-related protein 1 (B7RP-1) in vivo dramatically reduces germinal center formation and Ab production, the mechanism(s) remains unclear. An optimal T cell-dependent Ab response requires T and B cell activation, expansion, differentiation, survival, and migration, and the ICOS-B7RP-1 interaction could be involved in any or all of these processes. Understanding this will have important implications for targeting ICOS-B7RP-1 therapeutically. We have therefore used a double-adoptive transfer system, in which all of the above events can be analyzed, to assess the role of ICOS-B7RP-1 in T cell help for B cell responses. We have shown that ICOS signaling is involved in the initial clonal expansion of primary and primed Th1 and Th2 cells in response to immunization. Furthermore, while ICOS-B7RP-1 interactions have no effect on the migration of T cells into B cell follicles, it is essential for their ability to support B cell responses.
Relationship between Behavioral and Objective Measures of Sound Intensity in Normal-Hearing Listeners and Hearing-Aid Users: A Pilot Study (2022)

Background: For hearing-impaired individuals, hearing aids are clinically fit according to subjective measures of threshold and loudness. The goal of this study was to evaluate objective measures of loudness perception that might benefit hearing aid fitting. Method: Seventeen adult hearing aid users and 17 normal-hearing adults participated in the study. Outcome measures including categorical loudness scaling, cortical auditory evoked potentials (CAEPs), and pupillometry. Stimuli were 1-kHz tone bursts presented at 40, 60, and 80 dBA. Results: Categorical loudness scaling showed that loudness significantly increased with intensity for all participants (p < 0.05). For CAEPs, high intensity was associated with greater P1, N1, and P2 peak amplitude for all listeners (p < 0.05); a significant but small effect of hearing aid amplification was observed. For all participants, pupillometry showed significant effects of high intensity on pupil dilation (p < 0.05); there was no significant effect of hearing aid amplification. A Focused Principal Component analysis revealed significant correlations between subjective loudness and some of the objective measures. Conclusion: The present data suggest that intensity had a significant impact on loudness perception, CAEPs, and pupil response. The correlations suggest that pupillometry and/or CAEPs may be useful in determining comfortable amplification for hearing aids.
Secretion of a Novel T-Lymphocyte Cytokine Possessing both Chemotactic and Growth Factor Activity by Serotonin-Stimulated Human Aortic Endothelial Cells (1994)

The development of an extralymphatic T-lymphocyte focus of inflammation requires chemoattractant-induced cell migration and growth factor-induced cell proliferation. In a previous study, we identified a novel 13- to 15-kDa T-lymphocyte-specific chemotactic cytokine, endothelial cell-derived lymphocyte chemoattractant activity (ED-LCA), secreted by serotonin-stimulated human aortic endothelial cells. Based on its physicochemical and functional characteristics and antibody inhibition studies, ED-LCA is distinct from previously identified endothelial cell-derived IL-1, IL-6, and IL-8. Because of the association between T-lymphocyte chemotactic and growth factor activity, in the current study, we investigated the effect of ED-LCA on T cell growth by assessing its capacity to induce markers of the passage of T cells from the resting (G0) state into the G1 phase of the cell cycle, such as receptors for IL-2 (IL-2R) and transferrin (TFR), and class II major histocompatibility complex antigens (HLA-DR). Incubation of G0 freshly isolated human T lymphocytes for 48 h with chromatographically resolved, partially purified ED-LCA resulted in a threefold increase in expression of IL-2R, a threefold increase in TFR, and a twofold increase in HLA-DR. Double antibody labeling demonstrated that IL-2R was induced in both CD4+ and CD8+ T cell subsets. Although incubation of human T cells with ED-LCA alone did not induce DNA synthesis, addition of exogenous IL-2 to T cells pulsed with ED-LCA for 24 h caused an increase in DNA synthesis with a stimulation index of 3.5. By up-regulating functional cell surface receptors for IL-2 on T lymphocytes and priming them to respond to exogenous IL-2, ED-LCA is a competence growth factor. By virtue of its effect on T cells, as a chemotactic and competence factor, this endothelial cell-derived mitoattractant could participate with other T-cell growth factors like IL-2 in the generation of an extralymphatic T-lymphocyte inflammatory response.
Regeneration of myenteric plexus in the mouse colon after experimental denervation with benzalkonium chloride (2003)

Recent reports suggest a far greater plasticity in nerve tissue than previously believed. As the digestive tract is exposed to a variety of insults, this question is relevant to enteric nerves, but little is known about their ability to recover from damage. To address this problem, we ablated the myenteric plexus of the mouse colon with the detergent benzalkonium chloride (BAC) and followed the ensuing morphologic changes for up to 60 days by using light- and electron microscopy. We found that, 2 days after BAC application, the treated area was essentially devoid of intact nerve elements. From day 7, new nerve fibers were observed within the denervated region. This growth progressed until, at days 30-60, newly grown nerve fibers were present in most of this region, and the pattern of muscle innervation was similar to the normal one. At least part of these fibers originated at neurons within intact ganglia surrounding the denervated region. The cross-sectional area of neurons near the denervated region at day 14 was 52% greater than controls. Glial cells were closely associated with the regenerating nerve fibers. From day 14 onward, we observed undifferentiated cells and differentiating neurons in ganglia surrounding the denervated region, and by day 30, new neurons were present in the myenteric region, along with regenerating nerve fibers. We conclude that the myenteric plexus is endowed with a considerable ability of regeneration and plasticity. The results provide evidence for the presence of stem cells and for an adult neurogenesis in this plexus.
Low Itraconazole Serum Concentrations Following Administration of Itraconazole Suspension to Critically Ill Allogeneic Bone Marrow Transplant Recipients (1995)

Preparation and administration of itraconazole as a suspension did not enhance drug absorption in these patients. Furthermore, efficacy of itraconazole suspension may be affected by physical compatibility and chemical stability of the extemporaneous preparations.
Index (2023)

This is an open access title available under the terms of a CC BY-NC-ND 4.0 License. It is free to read, download and share on Elgaronline.com. Shedding light on the future of urban spaces, this path-breaking book is a significant contribution to contemporary climate change scholarship. It synthesizes interdisciplinary research with practical policy, putting an emphasis on positive environmental and socially just outcomes and urban regeneration.
Mobile Sign Language Learning Outside the Classroom. (2012)

Copyright is held by the author/owner(s). CHI 2012 EIST Workshop ACM. Abstract The majority of deaf children in the United States are born to hearing parents with limited prior exposure to American Sign Language (ASL). Our research involves creating and validating a mobile language tool called SMARTSign. The goal is to help hearing parents learn ASL in a way that fits seamlessly into their daily routine.
Closure Stress Profiling and 3D Fracture Simulations of the Staged Field Experiment Well No. 2, Upper Travis Peak Formation, East Texas (1989)

Abstract The Staged Field Experiment (SFE) Well No. 2 is the second of four wells funded by the Gas Research Institute (GRI) for the advancement of research in fracturing and completion technology. This tight gas well is located in a lease owned by Amoco, in the North Appleby Field, Nacogdoches County of East Texas. The well is completed in the Travis Peak Formation which is a sequence of sand shale layers found from 8,000 to 10,000 ft. The permeability and porosity average approximately 0.05 to 0.08 md and 5 to 9 %, respectively. Extensive pre- and post-fracturing tests were conducted by a consortium of academic and industry participants under the direction of a main GRI contractor. These include the stress testing of 25 zones and two mini-fracturing treatments ranging in volumes up to 6550 bbls. This paper derives a closure stress profile and possible variations using these data and related field experience, and simulates the main fracture treatment using a three dimensional fracture simulator. The simulations suggest fracture width reduction (pinching) at the perforations because of the presence of a low stress zone below and unsymmetric fracture height growth.1 Significant fracture height is indicated by both field data analysis and simulations. Fracture treatment design strategy is significantly affected by this occurrence, which suggests changes to common fracture design practices of many operators in the area. The simulations are compared with post-fracturing field data analysis to assess the resulting fracture geometry and the predictive capabilities of the simulations. Fracture design strategies are suggested for the area resulting from the experience gained from the SFE No. 2 well.
Wheat Science-Today and Tomorrow. (1982)

Foreword Sir Otto Frankel Acknowledgements 1. The early history of wheat: earliest traces to the sack of Rome J. R. Harlan 2. Wheat genetic resources D. R. Marshall and A. H. D. Brown 3. Molecular aspects of wheat evolution: repeated DNA sequences W. J. Peacock, W. L. Gerlach and E. S. Dennis 4. Molecular aspects of wheat evolution: rubisco composition S. G. Wildman 5. Transfer of alien genetic material to wheat E. R. Sears 6. Prospects for wheat transformation J. Langridge 7. New approaches to wheat breeding C. J. Driscoll 8. Wheat: barley hybrids - the first eighty years K. W. Shepherd and A. K. M. R. Islam 9. Wheat and its rust parasites in Australia I. A. Watson 10. Wheat proteins: their chemistry and nutritional potential D. H. Simmonds 11. The development of the wheat flower: genetics and physiology O. H. Frankel, R. B. Knox and J. A. Considine 12. The interaction between the physiology and the breeding of wheat J. B. Passioura 13. Yield improvement in wheat: empirical or analytical? L. T. Evans 14. Competitive plants, communal plants, and yield in wheat crops C. M. Donald 15. Developments in wheat agronomy R. A. Fischer 16. Prospects R. Riley 17. Otto Frankel - contributions to wheat genetics M. J. D. White.
Mannich-type reactions in water using a hydrophobic polymer-supported sulfonic acid catalyst (2003)

Three-component Mannich-type reactions were efficiently catalyzed by hydrophobic polystyrene-supported sulfonic acid (PS–SO3H) in water as the sole solvent under mild conditions.
The effects of physical aging on the thermal and mechanical properties of an epoxy polymer (1991)

Abstract The effects of free volume on the thermal and mechanical properties of epoxies from diglycidyl ether of bisphenol A (DGEBA) and ethylene diamine (EDA) were investigated. The degree of free volume was controlled by the different thermal history. For fully cured expoxy systems, the density and modulus of both aged and quenched specimens decreased with increasing EDA concentration. However the yield stress of quenched specimens showed a maximum at about equal stoichiometric formulation, while that of aged ones decreased with increasing EDA concentration.
Singlet Oxygen Quenching by Resveratrol Derivatives† (2022)

We investigated the singlet oxygen quenching ability of several derivatives of trans-resveratrol which have been reported to have significant antioxidant ability, including photoprotective activity. We measured the total rate constants of singlet oxygen removal (k<sub>T</sub> ) by the methylated resveratrol derivative 1,3-dimethoxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]benzene, and the partially methylated resveratrol derivatives 4-((E)-2-(3,5-dimethoxyphenyl)ethenyl)phenol (pterostilbene), 5-[(E)-2-(4-methoxyphenyl)ethenyl]benzene-1,3-diol and (2R,3R)-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-2,3-dihydrochromen-4-one (dihydromyricetin). A protic solvent system results in higher k<sub>T</sub> values, except for the completely methylated derivative. We also investigated the ability of trans-resveratrol to directly act as a photosensitizer (rather than via secondary photoproducts resulting from other primary photochemical reactions) for the production of singlet oxygen but found that neither resveratrol nor any of its derivatives are able to do so. We then studied the chemical reactions of the methylated derivative with singlet oxygen. The main pathway consists of a [4 + 2] cycloaddition reaction involving the trans-double bond and the para-substituted benzene ring similar to what has been observed for trans-resveratrol. Unlike trans-resveratrol, the primary singlet oxygen product undergoes a second [4 + 2] cycloaddition with singlet oxygen leading to the formation of diendoperoxides. A second reactivity pathway for both trans-resveratrol and the methylated derivative leads to the formation of aldehydes via cleavage of a transient dioxetane.
Clinicopathologic characteristics of 342 patients with multicentric Castleman disease in Japan (2019)

<b>Objectives:</b> To assess the clinicopathologic features of Multicentric Castleman disease (MCD) patients in Japan.<b>Methods:</b> We assessed baseline data for 342 Japanese MCD patients with a biopsy-proven diagnosis, enrolled in a prospective, observational study for tocilizumab treatment.<b>Results:</b> Of 342 patients, 86.0% had plasma-cell type. None had a family history of MCD. Median disease duration of MCD was 3.7 years. Mean body weight and body mass index tended to be lower than those in the general Japanese population. The most common clinical presentations besides lymphadenopathy included fatigue (61.7%), pulmonary involvement (42.7%), and splenomegaly (41.8%). Secondary amyloidosis was reported in 34 patients (9.9%). Laboratory abnormalities included decreased hemoglobin and albumin, and increased acute-phase proteins, serum immunoglobulins, and interleukin-6 (IL-6). IL-6 levels among the MCD patients tested in this study were correlated with levels of albumin, hemoglobin, triglyceride, total cholesterol, C-reactive protein, fibrinogen and immunoglobulin G (Spearman's correlation coefficient, |<i>r</i>| = 0.28-0.59).<b>Conclusion:</b> The clinical features and laboratory abnormalities are similar to those previously reported in other countries, besides higher rates of pulmonary involvement, secondary amyloidosis, and ECG abnormalities. Our results imply that IL-6 is involved in MCD pathogenesis. These findings would be informative for diagnosis and appropriate treatment for MCD.
N,N′-Bis(ethyldiphenylphosphino)ethylenediamineP,P′-dioxide (2005)

The mol­ecule of the title compound, C30H34N2O2P2 or Ph2P(O)N(Et)CH2CH2(Et)N(O)PPh2, has crystallographically imposed centrosymmetry. The P—N bond length of 1.656 (2) Å is less than the accepted value for a single P—N bond. The P—O bonds [1.4818 (18) Å] are also short because of double-bond character.
Electrical after-effects in Pb(Ti, Zr)O3 ceramics (1977)

Pb(Ti, Zr)O3 ceramics doped with Al, Mn or Fe exhibit constricted or asymmetrically displaced hysteresis loops. This distortion is due to an internal bias field Ei which can exceed the coercive field strength. Ei depends on the Ti/Zr ratio and on the kind of dope, and it increases with increasing doping concentration.After repeated cycling of the hysteresis loop the distortion disappears. This process, called “hysteresis relaxation,” obeys a time law of the form Ei(t) ∼exp(-t/τ)and is found to behave both like a field and thermally activated process. The activation energy of all investigated specimens doped with transition metal ions (Mn, Fe) lies between 0.6 and 0.7 eV, that of Al-doped samples is about 0.8 eV.Comparison of the behaviour of the dielectric and mechanical losses with that of the internal bias shows that these effects are closely correlated. From this correlation some conclusions can be drawn concerning the nature of Ei, the physical causes of the observed after-effects, and the influence of the kind of dope on the losses.Al-doped Pb(Ti, Zr)O3 ceramics exhibit an intergranular second phase which collects space charges during aging. The resulting space charge field is equivalent to an internal bias field which impresses an overall preferred direction of polarization on each crystallite.Fe and Mn are incorporated into the lattice. The resulting defects can either act as pinning points for the domain walls or give rise to anisotropic centres which favour a certain direction of polarization. This in turn stabilizes the domain configuration and reveals itself experimentally as an internal bias field.
Collaborating around collections (2004)

This paper explores the embodied interactional ways in which people naturally collaborate around and share collections of photographs. We employ ethnographic studies of paper-based photograph use to consider requirements for distributed collaboration around digital photographs. Distributed sharing is currently limited to the 'passing on' of photographs to others, by email, webpages, or mobile phones. To move beyond this, a fundamental challenge for photoware consists of developing support for the practical achievement of sharing 'at a distance'. Specifically, this entails augmenting the natural production of accounts or 'photo-talk' to support the distributed achievement of sharing.
Real-Time Event-Driven Classification Technique for Early Detection and Prevention of Myocardial Infarction on Wearable Systems (2018)

A considerable portion of government health-care spending is allocated to the continuous monitoring of patients suffering from cardiovascular diseases, particularly myocardial infarction (MI). Wearable devices present a cost-effective means of monitoring patients' vital signs in ambulatory settings. A major challenge is to design such ultra-low energy devices for long-term patient monitoring. In this paper, we present a real-time event-driven classification technique based on the random forest classification scheme, which uses a confidence-related decision-making process. The main goal of this technique is to maintain a high classification accuracy while reducing the complexity of the classification algorithm. We validate our approach on a well-established and complete MI database (Physiobank, PTB Diagnostic ECG database). Our experimental evaluation demonstrates that our real-time classification scheme outperforms the existing approaches in terms of energy consumption and battery lifetime by a factor of 2.60, with no classification quality loss.
Confocal SWIR imaging and 3D range finding using InGaAs P-i-N and APD detector arrays (2004)

In this presentation, we discuss the design and fabrication of a densely packed array of InGaAs APDs where each pixel contains both a low-noise PIN imaging detector and a high band-width APD.