gebhart/patrepeval huggingface dataset:
The myofibroblast in wound healing and fibrosis: answered and unanswered questions (2016)

The discovery of the myofibroblast has allowed definition of the cell responsible for wound contraction and for the development of fibrotic changes. This review summarizes the main features of the myofibroblast and the mechanisms of myofibroblast generation. Myofibroblasts originate from a variety of cells according to the organ and the type of lesion. The mechanisms of myofibroblast contraction, which appear clearly different to those of smooth muscle cell contraction, are described. Finally, we summarize the possible strategies in order to reduce myofibroblast activities and thus influence several pathologies, such as hypertrophic scars and organ fibrosis.
Formation of Photo-Responsive Surfaces by Surface-Initiated Ring Opening Metathesis Polymerization and Atom Transfer Radical Polymerization: Reversible Optodes for Metal Ion Sensors (2010)

In this work, we report on the grafting of photochromic polymer brushes from oxide surfaces using surface-initiated ring-opening metathesis polymerization (ROMP) and atom transfer radical polymerization (ATRP). The spiropyran-based homopolymers were synthesized from norbornyl derivatives of spiropyran using ROMP in the presence of Grubbs Generation II catalyst, whereas copolymers of methacrylate based spiropyran (SPMA) and different methacrylate derivatives were synthesized using surface-initiated ATRP. In both cases, polymer growth was monitored by ellipsometry and atomic force microscopy (AFM). For polymer brushes prepared by ROMP, the growth of the polymer film is strongly influenced by the monomer: catalyst ratio as well as reaction time. Reaction conditions were optimized to provide brushes with controllable thickness up to 120 nm. For copolymers prepared by ATRP, the polymerization proceeds in a living fashion, and copolymer brushes with thickness up to 80 nm were prepared. These densely packed and highly smooth polymer films were successfully used as surfaces with switchable wettability. Also, these films were used as reversible, photoswitchable optical sensors that show selectivity for different metal ions. Covalently bound polymer chains allow for an increase in sensor stability, impart a rapid response to analyte, and provide reversible, switchable sensor surfaces with longer lifetimes.
Evaluation of in-line nondestructive assay systems. Progress report, July 1-September 30, 1979 (1980)

Specified instruments for in-line nondestructive assay of process streams in spent nuclear fuels will be tested under realistic conditions for use in effective process control and materials counting. Progress in this project from July 1 to September 30, 1979 is described.
Effects of a new C5a receptor antagonist on C5a‐ and endotoxin‐ induced neutropenia in the rat (1999)

A new C5a receptor antagonist, the cyclic peptide Phe-[Orn-Pro-D-cyclohexylalanine-Trp-Arg], (F-[OPdChaWR]), was tested for its ability to antagonize the neutropenic effects of both C5a and endotoxin in rats. Human recombinant C5a (2 microg kg(-1) i.v.) caused rapid neutropenia, characterized by an 83% decrease in circulating polymorphonuclear leukocytes (PMNs) at 5 min. Administration of F-[OPdChaWR] (0.3-3 mg kg(-1) i.v.), did not affect the levels of circulating PMNs but, when given 10 min prior to C5a, it inhibited the C5a-induced neutropenia by up to 70%. Administration of E. Coli lipopolysaccharide (LPS, 1 mg kg(-1) i.v.) also caused neutropenia with an 88% decrease in circulating PMNs after 30 min. When rats were pretreated with F-[OPdChaWR] (0.3 - 10 mg kg(-1) i.v.) 10 min prior to LPS, there was a dose-dependent antagonism of the neutropenia caused by LPS, with up to 69% reversal of neutropenia observed 30 min after LPS administration. These findings suggest that C5a receptor antagonists may have therapeutic potential in the many diseases known to involve either endotoxin or C5a.
Cyclin E Is a Target of WT1 Transcriptional Repression (2002)

WT1 was originally identified as a Wilms' tumor suppressor gene, but it may have oncogenic potential in leukemia and in some solid tumors. WT1 is a transcription factor that has been implicated in the regulation of target genes related to apoptosis, genitourinary differentiation, and cell cycle progression. Because induction of WT1 leads indirectly to increased p21 expression in osteosarcoma cells, we investigated the possibility that other genes involved in the G(1)/S phase transition might also be WT1 targets. Cyclin E plays a crucial role in the cell cycle by activating cyclin-dependent kinase 2, which phosphorylates Rb, leading to progression from G(1) into S phase. We identified several WT1 binding sites in the cyclin E promoter. We demonstrate that WT1 binds to these sites and that in transient transfection assays WT1 represses the cyclin E promoter. This activity is dependent on the presence of a binding site located downstream of the transcription start site. In intact cells, induction of WT1 expression down-regulates cyclin E protein levels. These results provide the first demonstration that WT1 can directly modulate the expression of a gene involved in cell cycle progression.
Adrenal Function in Chickens Experiencing Mercury Toxicity , , (1975)

Dietary mercury when administered to young chickens via the drinking water depressed growth, increased the rate of mortality and inhibited the normal maturation of the adrenal glands. Additionally, deficiencies of cholesterol and corticosterone were demonstrated in the adrenals. The exogenous administration of 0.5 or 1.5 mg. of corticosterone/100 gm. of body weight alleviated, in part, the toxic effects of mercury as evidenced by a rapid increase in body weight.
Evidence for the Formation of Acylated or Phosphorylated Monoperoxyphthalates in the Catalytic Esterolytic Reactions in Cationic Surfactant Aggregates (1997)

Monoperoxyphthalate (MPP) was solubilized in three different aqueous cationic surfactant aggregates composed of (i) a micellar cetyltrimethylammonium chloride (CTACl) solution; (ii) an oil-in-water (O/W) microemulsion (ME) stabilized by CTACl, and a cosurfactant, tert-butyl alcohol, and (iii) a vesicular medium composed of dispersions of dihexadecyldimethylammonium chloride (DHDAC). At pH approximately 8.5 and 25 degrees C, each of these formulations was used to cleave p-nitrophenyl diphenyl phosphate (PNPDPP). The aggregate and the maximum pseudo-first-order rate constants ([MPP] = 4 x 10(-)(5) M, and [PNPDPP] = 1 x 10(-)(5) M) for the PNPDPP cleavages are the following: buffer alone, 0.00034 s(-)(1); micelle: 0.024 s(-)(1); ME: 0.0048 s(-)(1); and vesicle: 0.025 s(-)(1). Importantly all the catalytic formulations showed "turnover" behavior in the presence of excess substrates. By the combined use of (1)H- and (31)P-NMR spectrometry and synthesis, it was possible to provide evidence for the formation of acylated or phosphorylated monoperoxypthalates in the catalytic hydrolyses in cationic surfactant aggregates.
Nitrobenzylthioinosine binding cooperativity in chromaffin tissue membranes. (1992)

The nucleoside transporter present in chromaffin tissue membranes has been studied by [3H]nitrobenzylthioinosine (NBTI) binding. This ligand presents a high affinity, with a Kd value of 2.1 +/- 0.2 nM and a Bmax of 1.7 +/- 0.2 pmol/mg protein. From the Scatchard and the semilogarithmic graphical representations a positive cooperativity was deduced, with a Hill coefficient of 1.7 +/- 0.4. In displacement studies of NBTI by the non labelled compound, the Hill coefficient was also higher than 1 (1.44 +/- 0.11) in the presence of ATP. This nucleotide seems necessary to maintain the number of high affinity binding sites.
Angiotensin II Induces Translocation of Protein Kinase C α and ε in Neonatal Rat Cardiac Myocytes (2001)

Abstract Angiotensin II (Ang II) plays an important role in heart development and has been shown to stimulate the formation of premyofibrils and differentiation of cardiac myocytes. Ang II signaling occurs through two types of receptors, the AT1 and AT2 receptors, both of which appear to play a role in the development of the myocardium. Through the use of specific Ang II receptor blockers it as been shown that blocking the AT1 receptor with Losartan (Merck) inhibits the formation of premyofibrils and sarcomere formation and that blocking the AT2 receptor with PD123,319 (Parke-Davis) inhibits the formation of trabeculae in the developing heart. In a number of cases it has been shown that signal transduction mechanisms operate through different growth factor receptors and elicit specific responses within a cell type. Protein kinase C (PKC) is a family of closely related signal transduction enzymes that phosphorylate proteins on serine or threonine residues.
Suture Contamination by Surface Powders on Surgical Gloves (1983)

Recent studies have shown that many glove manufacturers still are using talc as a glove-mold release agent. The removal of talc particles from the patient-contact side of the gloves is difficult and incomplete with the use of recommended washing and wiping procedures. As a result, a shedding hazard exists that may ultimately be related to granulomatous reactions. In our study, shedding was demonstrated to be hazardous because of suture contamination with talc particles.
A comparison of perioperative outcomes of laparoscopic versus open nephroureterectomy for upper tract urothelial carcinoma: a propensity score matching analysis (2021)

Laparoscopic RNU is associated with shorter hospital stay, but longer operative time in comparison to open RNU. Otherwise, there were no differences in other perioperative outcomes between these surgical modalities even after propensity score matching. The choice to offer laparoscopic or open RNU in the treatment of UTUC should not be based on concerns of different safety outcomes.
Arginine 485 of human serum albumin interacts with the benzophenone moiety of ketoprofen in the binding pocket of subdomain III A and III B. (2012)

Arylpropionic acid nonsteroidal anti-inflammatory drusg (NSAIDs) primarily bind to subdomain III A (site II) of human serum albumin (HSA). Ketoprofen (KP), an arylpropionic acid that contains a photoreactive benzophenone moiety, was used to photolabel the binding region of site II. LC/Q-TOF mass spectrometry determination revealed that R485 was the amino acid residue that formed covalent adduct with the benzophenone moiety of KP. Point mutation of arginine 485 to alanine showed a slight decrease in the overall binding percentage of KP when compared to that of native HSA. The induced circular dichroism spectral data of KP with both R485A and native albumin confirmed the photolabeling findings. Interestingly, an increase in the extent of [14C]KP covalent adduct formation with the 11.6 kDa peptide derived from subdomain IIB-IIIA was observed for R485A. In contrast, mutation of arginine 410 caused a significant reduction of binding percentage, confirming the importance of this residue in high affinity binding of arylpropionic acid derivatives. This may indicate that while KP's carboxylate interacts electrostatically with arginine 410, the benzophenone moiety may have swung away from helix 6 in the absence of arginine 485. In this study, photolabeling of native and mutants albumins, R485A and R410C with [14C]KP confirmed that R485 involved in the non-electrostatic interaction with the benzophenone moiety of KP, but not vital to hold KP in the binding pocket of subdomain IIIA.
Free-viewpoint image synthesis from multiple-view images taken with uncalibrated moving cameras (2005)

In this paper, we propose methods for free-viewpoint image synthesis from multiple-view images taken with uncalibrated cameras. In our method, two viewpoints are selected as basis images for defining a projective 3D coordinate of the object scene in which the scene structure is recovered from the input multiple-view images. The 3D coordinate is defined by the image coordinates of the selected two basis images according to the epipolar geometry between those two images, which is represented by a fundamental matrix. The multiple-view images are also related to the projective 3D coordinate by their epipolar geometry to the basis images. Based on such a framework, we do not need to strongly calibrate the cameras, so we can recover 3D structure of the scene without effort for the camera calibration. In addition to that, we can also render free-viewpoint images from hand-held moving cameras. We will demonstrate the effectiveness of the proposed method by showing free-viewpoint images from multi-view images taken with hand-held moving cameras.
Metabolic Tumor Volume by 18F-FDG PET/CT Can Predict the Clinical Outcome of Primary Malignant Spine/Spinal Tumors (2017)

MTV was a more accurate predictor of PFS and OS in PMSTs compared to TLG or SUV<sub>max</sub> and helped decision-making for guiding rational treatment options.
Contact laws between nanoparticles: the elasticity of a nanopowder (2018)

Studies of the mechanical contact between nanometer-scale particles provide fundamental insights into the mechanical properties of materials and the validity of contact laws at the nanoscale which are still under debate for contact surfaces approaching atomic dimensions. Using in situ Brillouin light scattering under high pressure, we show that effective medium theories successfully predict the macroscopic sound velocities in nanopowders if one takes into account the cementation of the contacts Our measurements suggest the relevance of the continuum approach and effective medium theories to describe the contact between nanoparticles of diameters as small as 4 nm, i.e. with radii of contact of a few angstroms. In particular, we demonstrate that the mechanical properties of nanopowders strongly depend on the surface state of the nanoparticles. The presence of molecular adsorbates modifies significantly the contact laws.
The role of GPI-anchored proteins in the preferential binding and infection of poxviruses with primary human monocytes (105.19) (2011)

Abstract The poxviruses including vaccinia virus (VV) and canarypox virus (ALVAC) have shown a strong preference for binding and infection of human cells from the monocytic lineage, particularly primary human monocytes (PHMs). In this study, we investigated whether specific molecules on the surface of PHMs regulate the preferential binding and infection of VV and ALVAC to this cell population. We found that the cleavage of glycosylphosphatidylinositol-anchored proteins (GPI-APs) on primary human monocytes by phosphatidylinositol-specific phospholipase C (PI-PLC) and the blockage of GPI-APs with mouse sera raised against GPI-APs significantly reduced the binding of VV and ALVAC to the cell surface, and subsequently inhibited viral infection. This reduction is not related to abatement of phagocytosis as internalization of latex beads by PHMs was not affected by PI-PLC digestion. As well, the human monocytic cell lines THP-1, U937 and U1 express high, moderate and low levels of surface GPI-APs, respectively. The susceptibility of these cells to VV and ALVAC infection correlated to levels of surface expression of GPI-APs. In addition, THP-1 cells showed reduced susceptibility to VV and ALVAC infection when they were mutated by ethyl methanesulfonate (EMS) or aerolysin (AE) to express low or undetectable surface GPI-APs. Thus, specific GPI-APs on the surface of monocytes are involved in poxvirus binding and infection, and may act as monocyte-specific surface receptors for poxviruses.
Deformable 2D-3D Registration of Vascular Structures in a One View Scenario (2009)

Alignment of angiographic 3D scans to 2D projections is an important issue for 3D depth perception and navigation during interventions. Currently, in a setting where only one 2D projection is available, methods employing a rigid transformation model present the state of the art for this problem. In this work, we introduce a method capable of deformably registering 3D vessel structures to a respective single projection of the scene. Our approach addresses the inherent ill-posedness of the problem by incorporating a priori knowledge about the vessel structures into the formulation. We minimize the distance between the 2D points and corresponding projected 3D points together with regularization terms encoding the properties of length preservation of vessel structures and smoothness of deformation. We demonstrate the performance and accuracy of the proposed method by quantitative tests on synthetic examples as well as real angiographic scenes.
On the Mechanism of Hormone Recognition and Binding by the CCK-B/Gastrin Receptor (1997)

Lipidation with long-chain di-fattyacyl-glycerol moieties was used to anchor gastrin in CCK peptides irreversibly to lipid bilayers lipopeptide transfer to model phospholipid bilayers is fast and quantitative, leading to a different mode of insertion of lipo-gastrin and lipo-CCK in lipid layers. Lipo-gastrin remains exposed to the bulk solvent in a predominantly random coil structure as a consequence of electrostatic repulsion, whereas lipo-CCK exhibits a pronounced tendency to form peptide domains with insertion of its C-terminus into more hydrophobic compartments of the bilayers. Thereby Ca2+ at physiological concentrations favours this aggregational phenomenon. Since both lipo-peptides were found to retain almost full receptor affinity despite their irreversible anchorage to the bilayer, a membrane-bound pathway in the receptor recognition and binding process is indeed possible. According to the data collected in this study, CCK might possibly use this pathway, whereas accumulation of gastrin on the cell membrane with prefolding of the ligand at the water/lipid interface is hardly conceivable. Nevertheless the observed receptor interaction of the deliberately membrane-anchored gastrin offers interesting constraints for computational docking experiments on a modelled CCK-B/gastrin receptor by additionally taking into account information derived from mutagenesis studies. Despite the limitations of such modelling experiments, the resulting picture of the gastrin/receptor complex allowed the visualization and rationalization of the experimental results of the extensive structure-function studies performed previously on this family of gastrointestinal hormones.
Increased Nuclear Localization of Transcription Factor Y-Box Binding Protein 1 Accompanied by Up-Regulation of P-glycoprotein in Breast Cancer Pretreated with Paclitaxel (2005)

The results of the present study suggested that YB-1 may be involved in the development of resistance to paclitaxel in breast cancer.
Frequency conversion of Continuous-Wave fiber lasers with periodically-poled non-linear crystals: RIN and efficiencies. (2011)

This paper deals with SHG of CW fiber lasers with periodically-poled crystals. We compare SHG efficiencies obtained with single-frequency and with narrow linewidth longitudinally multimode fiber lasers, as well as intensity noises in the visible.
Liberation in Southern Africa: Comparing Democratic Consolidation in South Africa and Zimbabwe (2019)

The research question that this thesis seeks to answer is: in what ways do liberation movements impact a nation’s experience with democratic consolidation after conflict ends? When the rebel organization is relatively weaker than the state, the state can control their actions. The liberation movement will not be able to manipulate the state, but will be able to impose costs on status quo maintenance. This will then lead the two parties to form a democratic pact and negotiate, resulting in the organization’s increased preference for democratic methods in the future. However, when the liberation movement and the state have relatively equal strength, the organization will be able to impose its will on the state and drastically increase the costs the government incurs to maintain the status quo. This will then lead the state to quickly end the conflict through negotiations where the liberation movement will be able to manipulate the government into conceding to their terms. The fact that the organization achieved its outcome goals through the use of violence will cement those methods once the organization becomes an institutionalized political party. This theory is tested using a comparative case study of the wars for liberation in South Africa and Zimbabwe. In the case of the ANC in South Africa, the liberation movement was largely controlled by the state, but the organization was still able to impose costs for status quo maintenance. This then resulted in the government’s desire to end the conflict while still in a position of authority. This necessitated the ANC to utilize diplomatic and democratic methods to achieve power. In the war for liberation in Zimbabwe, ZANU/ZAPU forces were able to affect the stability of the nation that resulted in the government’s decision to concede to the terms of the group. This allowed the organization to become an institutionalized political party that consolidated authority once in power.
An Aligned-Gap and Centered-Gap Rectangular Multiple Split Ring Resonator for Dielectric Sensing Applications (2014)

This paper presents the design and development of a planar Aligned-Gap and Centered-Gap Rectangular Multiple Split Ring Resonator (SRR) for microwave sensors that operates at a resonance frequency around 5 GHz. The sensor consists of a microstrip transmission line loaded with two elements of rectangular SRR on both sides. The proposed metamaterial sensors were designed and fabricated on Rogers RT5880 substrate having dielectric constant of 2.2 and thickness of 0.787 mm. The final dimension of the proposed sensor was measured at 35 × 14 mm2. Measured results show good agreement with simulated ones as well as exhibiting high Q-factor for use in sensing application. A remarkably shift of resonance frequency is observed upon introduction of several sample with different dielectric value.
Epitaxie silicium avancee en milieu industriel (1998)

L'epitaxie silicium en phase vapeur est une technique de depot de plus en plus utilisee en microelectronique car elle permet de realiser des structures complexes avec un bon controle de l'epaisseur et de la composition des differentes couches. L'interet de cette these reside dans l'acquisition d'une expertise sur l'epitaxie dans le milieu industriel. Elle comprend tout d'abord l'etude de l'epitaxie a haute temperature a partir du dcs utilisee dans la realisation des couches enterrees. L'objectif principal de cette partie reside dans la reduction des auto-dopages bore et arsenic associes a ces couches, en vue d'ameliorer les performances des transistors bipolaires dans la technologie bicmos. Ainsi, l'etude des mecanismes mis en jeu a permis d'une part d'expliquer l'origine des differences observees pour ces deux auto-dopages et de mettre en place des solutions originales (brevets) permettant de reduire chacun d'eux sans degradation de l'autre. Nous nous sommes ensuite tournee vers le developpement de l'epitaxie avancee a basse temperature. Celle ci comprend d'une part l'epitaxie selective avec comme principale application la fabrication des drains/sources sureleves des transistors cmos. Cette partie presente une approche de la croissance et de la selectivite du systeme dcs/hcl/h#2 sur des plaques comportants des motifs d'oxyde. Cette etude comprend d'autre part le developpement de l'hetero-epitaxie si#1##xge#x/si pour la realisation des bases epitaxiees des transistors bipolaires a hetero-jonctions (tbh). Les caracteristiques de la croissance de films contraints sige sur un substrat de silicium sont presentees ainsi que les resultats electriques obtenus sur le premier lot passe a crolles.