gebhart/patrepeval huggingface dataset:
Reconfigurable Infrared Photodetector Based on Asymmetrically Doped Double Quantum Wells for Multicolor and Remote Temperature Sensing (2016)

Multicolor Infrared (IR) detectors provide new solutions in physical, chemical, and biological sensing and imaging. Multispectral sensing makes it possible to increase detection sensitivity, to improve object identification and discrimination capabilities, and to measure the absolute temperature of the object regardless of its emissivity and geometry. Numerous practical applications of such detectors include defense and commercial technologies, such as night vision, low visibility navigation, monitoring of industrial high-temperature processes, noncontact temperature imaging, target detection and tracking, and remote earth observations. Nanostructures with double quantum wells (DQWs) are very promising for multicolor sensing. They demonstrate strong double-peak photoresponse, where the peak positions and their magnitudes may be controlled by the bias voltage via the charge redistribution between DQWs. This chapter presents the effects of DQW asymmetric doping on the parameters of IR detector, its spectral selectivity, and bias tunability. High bias-tunable spectral selectivity of asymmetrically doped DQWs makes nanomaterials very attractive for precise thermometric measurements.
Primitive Phospholamban- and Sarcolipin-like Peptides Inhibit the Sarcoplasmic Reticulum Calcium Pump SERCA (2022)

Intracellular calcium signaling is essential for all kingdoms of life. An important part of this process is the sarco-endoplasmic reticulum Ca<sup>2+</sup>-ATPase (SERCA), which maintains the low cytosolic calcium levels required for intracellular calcium homeostasis. In higher organisms, SERCA is regulated by a series of tissue-specific transmembrane subunits such as phospholamban in cardiac muscles and sarcolipin in skeletal muscles. These regulatory axes are so important for muscle contractility that SERCA, phospholamban, and sarcolipin are practically invariant across mammalian species. With the recent discovery of the arthropod sarcolambans, the family of calcium pump regulatory subunits appears to span more than 550 million years of evolutionary divergence from arthropods to humans. This evolutionary divergence is reflected in the peptide sequences, which vary enormously from one another and only vaguely resemble phospholamban and sarcolipin. The discovery of the sarcolambans allowed us to address two questions. How much sequence variation is tolerated in the regulation of mammalian SERCA activity by the transmembrane peptides? Do divergent peptide sequences mimic phospholamban or sarcolipin in their regulatory activities despite limited sequence similarity? We expressed and purified recombinant sarcolamban peptides from three different arthropods. The peptides were coreconstituted into proteoliposomes with mammalian SERCA1a and the effect of each peptide on the apparent calcium affinity and maximal activity of SERCA was measured. All three peptides were superinhibitors of SERCA, exhibiting either phospholamban-like or sarcolipin-like characteristics. Molecular modeling, protein-protein docking, and molecular dynamics simulations revealed novel features of the divergent peptides and their SERCA regulatory properties.
Effects of Thermal Annealing on the Properties of Zirconium-Doped MgxZn1−XO Films Obtained through Radio-Frequency Magnetron Sputtering (2021)

Zirconium-doped Mg<sub>x</sub>Zn<sub>1-x</sub>O (Zr-doped MZO) mixed-oxide films were investigated, and the temperature sensitivity of their electric and optical properties was characterized. Zr-doped MZO films were deposited through radio-frequency magnetron sputtering using a 4-inch ZnO/MgO/ZrO<sub>2</sub> (75/20/5 wt%) target. Hall measurement, X-ray diffraction (XRD), transmittance, and X-ray photoelectron spectroscopy (XPS) data were obtained. The lowest sheet resistance, highest mobility, and highest concentration were 1.30 × 10<sup>3</sup> Ω/sq, 4.46 cm<sup>2</sup>/Vs, and 7.28 × 10<sup>19</sup> cm<sup>-3</sup>, respectively. The XRD spectra of the as-grown and annealed Zr-doped MZO films contained Mg<sub>x</sub>Zn<sub>1-x</sub>O(002) and ZrO<sub>2</sub>(200) coupled with Mg(OH)<sub>2</sub>(101) at 34.49°, 34.88°, and 38.017°, respectively. The intensity of the XRD peak near 34.88° decreased with temperature because the films that segregated Zr<sup>4+</sup> from ZrO<sub>2</sub>(200) increased. The absorption edges of the films were at approximately 348 nm under 80% transmittance because of the Mg content. XPS revealed that the amount of Zr<sup>4+</sup> increased with the annealing temperature. Zr is a potentially promising double donor, providing up to two extra free electrons per ion when used in place of Zn<sup>2+</sup>.
ALDH1 expression is enriched in breast cancers arising in young women but does not predict outcome (2013)

In younger women, ALDH1 was more highly expressed, and it correlated with ER negativity. It, however, did not predict survival in this study.
Long‐term use of continuous subcutaneous hydrocortisone infusion therapy in patients with congenital adrenal hyperplasia (2018)

Long-term use of CSHI is a safe and well-tolerated treatment option in a select set of adults with classic CAH. Improvements observed short term in disease control and subjective health status continued long term.
Stress-Induced Leakage Current and Lateral Non-Uniform Charge Generation In Thermal Oxides Subjected to Negative-Gate-Voltage Impulse Stressing (1998)

1998 International Conference on Solid State Devices and Materials,Stress-Induced Leakage Current and Lateral Non-Uniform Charge Generation In Thermal Oxides Subjected to Negative-Gate-Voltage Impulse Stressing
Racemic synthesis and enantiomeric conversion of [1‐13C] valine (1993)

Abstract A Strecker synthesis of isobutyraldehyde, K 13 CN and ammonia produced D,L‐[1‐ 13 C] valine in 83% yield. This racemic mixtue was then converted to the L‐form via a D‐amino acid oxidase ‐ branched amino acid aminotransferase system in an overall yield of 75% based on K 13 CN. Given the generality of the Strecker synthesis as well as the broad substrate specificity of the oxidase and aminotransferase enzymes, it is anticipated that this procedure will be comparably efficient for most standard aliphatic and aromatic amino acids.
A preclinical study of tamoxifen in combination with bevacizumab (Avastin) for the treatment of ER-positive breast cancer (2005)

1091 Clinical studies have shown that elevated levels of VEGF are associated with poor response to tamoxifen treatment for estrogen receptor (ER)-positive breast cancer. Our previous study provided the first direct in vivo evidence that tumor cytosolic VEGF expression at a clinically relevant level not only increases tumor angiogenesis, but also is sufficient to promote ER-positive, tamoxifen-responsive, and non-metastatic breast tumor to become tamoxifen resistant and metastatic. We have developed a xenograft mouse model of ER-positive human breast cancer, in which VEGF expression is tightly controlled by doxycycline in drinking water. The VEGF level detected in the tumor sample is within a range that is found in patient biopsy samples. This study suggested a new function of VEGF in tamoxifen resistance and metastasis and indicated that inhibition of both ER-dependent and VEGF-induced tumor cell growth would be a potential therapy for breast cancer. This study was designed to test this hypothesis using tamoxifen and bevacizumab (Avastin™), a recombinant humanized monoclonal antibody against VEGF. The efficacy of the tamoxifen-Avastin combined therapy was evaluated with two arms of mice designed for early and late stage settings of the disease using the newly developed animal model of ER-positive breast cancer. For the early stage setting, mice received the combined and mono treatments when their tumors reached about 100 mm3 in size. Significant inhibitory effect on primary tumor growth was observed for both the combined treatment and the Avastin mono treatment (P
TextRank: Bringing Order into Text (2004)

In this paper, the authors introduce TextRank, a graph-based ranking model for text processing, and show how this model can be successfully used in natural language applications.
Early and Late Postoperative Application of 5-Fluorouracil Following Trabeculectomy in Refractory Glaucoma (1994)

Intraocular pressure (IOP) control was studied retrospectively in two groups of 14 consecutive patients following trabeculectomy with adjunctive postoperative 5-fluorouracil (5-FU) treatment. In one of the groups (the early-treatment group), 5-FU injections were started 2.4 +/- 0.6 days postoperatively; in the other group (the delayed-treatment group), they were started only when clinical signs suggested impending bleb failure (12.6 +/- 5.4 days postsurgery). The patients in the two groups were age-matched and had a similar history of previous failed glaucoma operations or diabetes, both of which are considered indications for postoperative 5-FU injections. The mean number of 5-FU injections and the total dose in the two groups did not differ significantly (5.3 +/- 0.8 and 5.5 +/- 1.1 injections, respectively; 26.4 +/- 3.9 and 27.5 +/- 5.3 mg 5-FU total dose, respectively). The average follow up for the two groups was 16.7 +/- 2.5 and 16.9 +/- 2.7 months, respectively. With an IOP of 18 mm Hg or less with or without medications considered a success, 42.8% of the delayed-treatment and 71.4% of the early-treatment cases were successful. More medications were required in the early-treatment group. Postoperative transient corneal epithelial defects occurred in 71.4% and 78.4% of the eyes in the late- and early-treatment groups, respectively, an insignificant difference. Conjunctival wound leak occurred in one patient (in the delayed-treatment group).(ABSTRACT TRUNCATED AT 250 WORDS)
Systematik hoch übersetzender koaxialer Getriebe (2010)

Gegenstand der vorliegenden Arbeit ist die Ermittlung geeigneter hoch übersetzender koaxialer Getriebekonzepte für Stellantriebe. Mittels einer Systematik wurden hierzu zunächst alle möglichen Getriebekonzepte bestehend aus maximal zwei miteinander gekoppelten Standardplanetengetrieben abgebildet. Zur Auswahl des optimalen Konzepts wurde eine Methode zur Optimierung und Bewertung entwickelt. Für eine Leitanwendung wurde mit der Methode das Wolfromgetriebe als optimales Konzept ausgewählt. Besonders einfach baut das Wolfromgetriebe ohne Steg. Die Arbeit zeigt hierfür einen Ansatz zur Wirkungsgradberechnung, der mit Versuchsergebnissen abgeglichen ist.
Fluorescence-Guided Surgery (2017)

Surgical resection of cancer remains an important treatment modality. Despite advances in preoperative imaging, surgery itself is primarily guided by the surgeon's ability to locate pathology with conventional white light imaging. Fluorescence-guided surgery (FGS) can be used to define tumor location and margins during the procedure. Intraoperative visualization of tumors may not only allow more complete resections but also improve safety by avoiding unnecessary damage to normal tissue which can also reduce operative time and decrease the need for second-look surgeries. A number of new FGS imaging probes have recently been developed, complementing a small but useful number of existing probes. In this review, we describe current and new fluorescent probes that may assist FGS.
Twelve‐hour duration testing of cream formulations of three repellents against Amblyomma americanum (2008)

The repellent efficacies of the U.S. military repellent 33% N,N-diethyl-3-methylbenzamide (deet), 10% and 20% (1S, 2'S) 2-methylpiperidinyl-3-cyclohexene-1-carboxamide (SS220) and 10% and 20% 1-methyl-propyl-2-(hydroxyethyl)-1-piperidinecarboxylate (Bayrepel) cream formulations on human volunteers against the lone star tick Amblyomma americanum (L.) were evaluated in a simulated forest floor environment over a 12-h testing period. At 2-h intervals, volunteers, with repellent applied in a 5-cm-wide band around each ankle, stood for 5 min in plastic tubs containing leaf litter and 100 host-seeking A. americanum nymphs. Ticks were allowed to remain on a volunteer's feet and ankles for an additional 5 min after the volunteer exited the tub. All repellent formulations provided high levels of protection for the entire 12 h. No ticks crossed 5-cm-wide bands of 20% SS220 and Bayrepel during any challenge, and thus 100% protection was afforded throughout the test. These formulations showed a long-lasting efficacy hitherto unknown in tick repellents intended for use on human skin.
Developing Basic Mathematics Skills Through the use of African-American Children's Literature (1997)

According to Farris (1993), quality children's literature, especially picture books, can be very helpful in teaching social studies concepts to elementary and middle school students. Children's literature can also be instrumental when teaching mathematical concepts.
Localization of the human salivary protein complex (SPC) to chromosome band 12p13.2 (1985)

In situ hybridization of a 3H-labeled probe containing a fragment from PRP-1, a genomic clone with human salivary proline-rich protein gene sequences, revealed significant labeling on the short arm of human chromosome 12 in metaphase preparations from two individuals. Fifty-three percent of metaphases exhibited labeling on one or both chromosomes 12. Additional cells scored at the 850-1,000 band level revealed a significant proportion (52% [32/61] grains, p less than 0.005) of the labeled sites on chromosome 12 to be on band 12p13.2. This probe for a human salivary proline-rich protein gene fragment, probably PMS, is from a cluster of 13 linked genes designated as the human salivary protein complex (SPC). Studies of the DNA of human-mouse somatic-cell hybrids have assigned the SPC to chromosome 12, but have not provided a regional localization (Azen et al, 1985). This paper reports the localization of the SPC to a specific chromosomal band, 12p13.2.
A stereo-fluoroscopic image-guided robotic biopsy scheme (2002)

This paper investigates some key issues in a simulation of a stereo-fluoroscopic image-guided robotic breast biopsy system: real-time 3D path planning and robot trajectory control with considerations of safety, tissue impedance, needle flexibility, and imaging time delay. It presents a robot control scheme which allows automatic and continuous adjustments on the needle inserting path according to a real-time 3D position feedback, and is applicable to soft tissue and organ biopsy, with the expected advantages of increased accuracy, short completion time, and minimal invasiveness to the patient. Simulation results are used to illustrate the effectiveness of the developed scheme.
Dynamic landscape maps for path planning and target assignment (2008)

In this paper, we present new concepts for path planning and cooperative target assignment for unmanned vehicles in uncertain environments. The approach is inspired by possible cognitive computing architectures used in mammalian brains for navigation tasks. A dynamic map based on sensor input and a diffusion equation is used to generate paths around obstacles to targets. Targets are assigned to each UAV based on simple priority logic or dynamic competition. Simulation results for a simple scenario with two UAVs and multiple targets are presented.
A technique for digital image registration used prior to subtraction of lung images in nuclear medicine (1990)

The aim of the approach to image registration described is to find a general relationship, described by polynomials, for the distribution of activity in the perfusion image compared to the distribution in the composite image of perfusion and ventilation. This technique was used because the actual spatial relationship between the lungs in both images will never be known prior to re-alignment. For each pair of images the spatial relationship is unique and is characterised by the coefficients of the polynomial expressions. The coefficients for each polynomial approximation are calculated using picture element locations (control points). These corresponding pairs are located manually at similar anatomical positions in both images with a user-guided screen cursor. The appropriate grey level for each pixel in the registered perfusion image is found in the original at coordinate locations which are returned by the polynomial expressions.
Systems and Methods for Convex Relaxations and Linear Approximations for Optimal Power Flow in Multiphase Radial Networks (2015)

Centralized node controllers in accordance with embodiments of the invention enable linear approximation of optimal power flow. One embodiment includes a centralized node controller including: a network interface, a processor, and a memory containing: a centralized power control application a network topology, where the network is multiphase unbalanced and comprises a plurality of connected nodes; wherein the processor is configured by the centralized controller application to: request node operating parameters from the plurality of connected nodes; calculate network operating parameters using a linear approximation of optimal power flow and the node operating parameters from the plurality of connected nodes; send network operating parameters to the plurality of connected nodes.
Facility Cooling Failure Analysis of Direct Liquid Cooling System in Data Centers (2018)

This work experimentally studies the impact of facility cooling failure of a direct liquid cooling (DLC) system on the IT equipment (ITE). The facility side of a DLC system removes the heat from a secondary loop — in direct contact with the ITE — and discard it in a chiller loop or ambient. The CPU utilization and coolant set point temperature (SPT) are varied to understand the effect of failure under different operating conditions. The ITE response is studied in terms of chip temperature and power, and fan speed. It was found that failure of the facility cooling system is not hazardous to the IT operation. The rate of change in temperature after failure is low and is sufficient to turn the ITE off safely. This is attributed to the surrounding air in the data center and the thermal mass of the cooling system.
The Circulating IGF System in Hepatocellular Carcinoma: The Impact of Liver Status and Treatment (2015)

The marked differences in IGF and IGFBP levels between patients with HCC, liver cirrhosis and healthy subjects are mainly explained by variations in liver status. Therefore, this study questions the clinical utility of circulating IGF variables as markers of HCC.
Bicyclic Bridgehead Phosphoramidite (Briphos) Ligands with Tunable π-Acceptor Ability and Catalytic Activity in the Rhodium-Catalyzed Conjugate Additions (2014)

A new type of bicyclic bridgehead phosphoramidites (briphos) is reported, where the geometrical constraints significantly enhance the π-acceptor ability compared with its monocyclic analogs. The briphos is shown to be highly efficient and tunable for Rh(I)-catalyzed conjugate additions of aryl boronic acids to α,β-unsaturated ketones and N-tosyl ketimines.
Disappearing and reappearing polymorphism inp-methylchalcone (2008)

For the system M1/3Re2/3O2 (M = Fe, Co, Ni) different rutile or rutile-derivated structural modifications were found depending on the temperature during high-pressure high-temperature syntheses. The crystal structures have been determined by single crystal X-ray diffraction. For synthesis temperature higher than 1300 , phases with tetragonal rutile aristotype structure (S. G. P42/mnm) and a statistical distribution of M-and Re-atoms on the metal site in the structure were obtained. At lower synthesis temperature, rutile-like structures with orthorhombic or monoclinic symmetry, partial order on M-and Re-sites and metallic Re-Re bonds were observed for Co1/3Re2/3O2 and Ni1/3Re2/3O2. A monoclinic CrWO4type structure (S. G. C2/m) with only Re-atoms on the 4g site and statistically distributed Ni-and Re-atoms on the 4i site was adopted by Ni1/3Re2/3O2. Single crystals Co1/3Re2/3O2 with orthorhombic CrWO4-type structure (S. G. F222) and also partially mixed Co,Repositions were found together with a monoclinic modification, which is isotypic to monoclinic Ni1/3Re2/3O2. Note, that another orhorhombic modification (S. G. Cmmm) was reported for the composition Co1/2Re1/2O2 with distinct positions of Co and Re and without any metallic Re-Re-bond [1]. Unfortunately, the synthesis conditions were not described in sufficient detail to allow a comparison with our preparation method. Ni1/3Re2/3O2 with the rutile-structure orders ferroor ferrimagnetically at 23.5 K, whereas tetragonal Co1/3Re2/3O2 shows two magnetic tranitions: below 17.5 K the ferromagnetic component dominates in contrast to an antiferromagnetic order between 27.0 and 17.5 K.
Aldisine Alkaloids from the Philippine Sponge Stylissa massa Are Potent Inhibitors of Mitogen-Activated Protein Kinase Kinase-1 (MEK-1) (2001)

Raf/MEK-1/MAPK cascade inhibitor activity-directed fractionation of the sponge Stylissa massa afforded eight known alkaloids: aldisine (1), 2-bromoaldisine (2), 10Z-debromohymenialdisine (3), 10E-hymenialdisine (4), 10Z-hymenialdisine (5), hymenin (6), oroidin (7), and 4,5-dibromopyrrole-2-carbonamide (8). Both 4 and 5 showed significant enzyme inhibitory activity (IC(50) 3 and 6 nM, respectively). Secondary assays identified these compounds as potent MEK-1 inhibitors. Compounds 4 and 5 also inhibited the growth of human tumor LoVo cells.
Development and Characterization of Magnetostrictive GaFe and Plasmonic Gold Thin Films (2015)

University of Minnesota Ph.D. dissertation. April 2015. Major: Electrical Engineering. Advisor: Bethanie Stadler. 1 computer file (PDF); xiv, 151 pages.
Cronobacter: An Emergent Pathogen Causing Meningitis to Neonates through their Feeds (2014)

The recognition of Cronobacter as a public health concern was raised when powdered infant formula (PIF) was linked to several neonatal meningitis outbreaks. It is an opportunistic pathogen that causes necrotising enterocolitis, infantile septicaemia, and meningitis which carries a high mortality rate among neonates. It has been also linked with cases of infection in adults and elderly. Over the past decade, much focus has been made on developing sensitive and specific characterisation, detection, and isolation methods to ascertain the quality of foods, notably contamination of PIF with Cronobacter and to understand its ability to cause disease. Whole genome sequencing has unveiled several putative virulence factors, yet the full capacity of the pathogenesis of Cronobacter has not yet been elucidated.