gebhart/patrepeval huggingface dataset:
Oblique rifting triggered by slab tearing and back-arc extension: the case of the Alboran rift in the eastern Betics (2022)

Abstract. The tectonic evolution of highly oblique continental margins that result from back-arc extension above lithospheric STEP faults is poorly understood. Here, we investigate the case of the Alboran margin in the eastern Betics characterized by crustal thinning of 15–10 km, oblique to the direction of slab retreat. The current deformation patterns indicate that oblique back-arc rifting is underway. However, it is unclear whether these conditions are those that prevailed during the formation of the metamorphic domes and intramontane basins. We review the temporal and spatial evolution of Neogene sedimentary basins and brittle deformation in the eastern Betics, and exploit offshore seismic reflection lines to propose a crustal-scale section across the oblique margin. The history of sediment infill and rates of subsidence combined with the analyses of fault slip data, confirm that brittle extension oriented from N20° E to EW occurred during an interval spanning from the Serravallian-early Tortonian to the late Tortonian (14–8 Ma). This extension is found associated with both normal and strike-slip regimes and the evolution of the strike-slip corridors flanking the metamorphic domes. The transtensional model forms a coherent scheme linking the ductile deformation associated with metamorphic domes and the formation of EW- and NW-SE/NNW-SSE-directed sedimentary basins in the brittle upper crust during the Tortonian. The oblique extension, which is closely associated with STEP faulting, occurred during the regional convergence between Africa and Iberia since the Miocene. Only recently, around 8 Ma, the slab detached, leading to local tectonic inversion. Such a type of narrow oblique rifted margin associated with transform-like plate boundaries is not unique but is expected to be hardly preserved in the geological record due to the transient nature of retreating subduction systems.
From laptop to lambda: outsourcing everyday jobs to thousands of transient functional containers (2019)

We present gg, a framework and a set of command-line tools that helps people execute everyday applications--e.g., software compilation, unit tests, video encoding, or object recognition--using thousands of parallel threads on a cloud-functions service to achieve near-interactive completion times. In the future, instead of running these tasks on a laptop, or keeping a warm cluster running in the cloud, users might push a button that spawns 10,000 parallel cloud functions to execute a large job in a few seconds from start. gg is designed to make this practical and easy.

With gg, applications express a job as a composition of lightweight OS containers that are individually transient (lifetimes of 1-60 seconds) and functional (each container is hermetically sealed and deterministic). gg takes care of instantiating these containers on cloud functions, loading dependencies, minimizing data movement, moving data between containers, and dealing with failure and stragglers.

We ported several latency-sensitive applications to run on gg and evaluated its performance. In the best case, a distributed compiler built on gg outperformed a conventional tool (icecc) by 2-5×, without requiring a warm cluster running continuously. In the worst case, gg was within 20% of the hand-tuned performance of an existing tool for video encoding (ExCamera).
Data from Mice Lacking <i>bi-1</i> Gene Show Accelerated Liver Regeneration (2023)

&lt;div&gt;Abstract&lt;p&gt;The liver has enormous regenerative capacity such that, after partial hepatectomy, hepatocytes rapidly replicate to restore liver mass, thus providing a context for studying &lt;i&gt;in vivo&lt;/i&gt; mechanisms of cell growth regulation. Bax inhibitor-1 (BI-1) is an evolutionarily conserved endoplasmic reticulum (ER) protein that suppresses cell death. Interestingly, the BI-1 protein has been shown to regulate Ca&lt;sup&gt;2+&lt;/sup&gt; handling by the ER similar to antiapoptotic Bcl-2 family proteins. Effects on cell cycle entry by Bcl-2 family proteins have been described, prompting us to explore whether &lt;i&gt;bi-1&lt;/i&gt;–deficient mice display alterations in the &lt;i&gt;in vivo&lt;/i&gt; regulation of cell cycle entry using a model of liver regeneration. Accordingly, we compared &lt;i&gt;bi-1&lt;/i&gt;&lt;sup&gt;+/+&lt;/sup&gt; and &lt;i&gt;bi-1&lt;/i&gt;&lt;sup&gt;−/−&lt;/sup&gt; mice subjected to partial hepatectomy with respect to the kinetics of liver regeneration and molecular events associated with hepatocyte proliferation. We found that &lt;i&gt;bi-1&lt;/i&gt; deficiency accelerates liver regeneration after partial hepatectomy. Regenerating hepatocytes in &lt;i&gt;bi-1&lt;/i&gt;&lt;sup&gt;−/−&lt;/sup&gt; mice enter cell cycle faster, as documented by more rapid incorporation of deoxynucleotides, associated with earlier increases in cyclin D1, cyclin D3, cyclin-dependent kinase (Cdk) 2, and Cdk4 protein levels, more rapid hyperphosphorylation of retinoblastoma protein, and faster degradation of p27&lt;sup&gt;Kip1&lt;/sup&gt;. Dephosphorylation and nuclear translocation of nuclear factor of activated T cells 1 (NFAT1), a substrate of the Ca&lt;sup&gt;2+&lt;/sup&gt;-sensitive phosphatase calcineurin, were also accelerated following partial hepatectomy in BI-1–deficient hepatocytes. These findings therefore reveal additional similarities between BI-1 and Bcl-2 family proteins, showing a role for BI-1 in regulating cell proliferation &lt;i&gt;in vivo&lt;/i&gt;, in addition to its previously described actions as a regulator of cell survival. [Cancer Res 2007;67(4):1442–50]&lt;/p&gt;&lt;/div&gt;
Antwerp and the Elizabethan Mind (1963)

Research Article| March 01 1963 Antwerp and the Elizabethan Mind S. M. Pratt S. M. Pratt Search for other works by this author on: This Site Google Modern Language Quarterly (1963) 24 (1): 53–60. https://doi.org/10.1215/00267929-24-1-53 Cite Icon Cite Share Icon Share Twitter Permissions Search Site Citation S. M. Pratt; Antwerp and the Elizabethan Mind. Modern Language Quarterly 1 March 1963; 24 (1): 53–60. doi: https://doi.org/10.1215/00267929-24-1-53 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search Books & JournalsAll JournalsModern Language Quarterly Search Advanced Search The text of this article is only available as a PDF. Copyright © 1963 by Duke University Press1963 Article PDF first page preview Close Modal Issue Section: Articles You do not currently have access to this content.
Family Transformations and the Well-being of Children: Recent Evidence from Canadian Longitudinal Data (2001)

This paper uses longitudinal data to examine negative child outcomes among young children in Canada. In following a cohort of children as they move through their early elementary school years, a slight decline in hyperactivity is documented, as is a slight increase in internalizing difficulties. After introducing a longitudinal dimension to our analysis, both family structure and income poverty are found to have a weaker effect on child outcomes than was initially anticipated. The current analysis also demonstrates the utility of LISREL’s “weighted least squares” estimation procedure in the development of structural equation models while working with ordinal and/or censored variables.
FT‐IR Imaging Hardware (2010)

This chapter contains sections titled: Introduction Systems Overview The Role of the FT-IR Spectrometer Optomechanical Considerations Detectors For IR Imaging Sampling Modes for IR Imaging IR Imaging Speed and Performance Considerations References
Mechanisms underlying subunit independence in pyramidal neuron dendrites (2013)

Pyramidal neuron (PN) dendrites compartmentalize voltage signals and can generate local spikes, which has led to the proposal that their dendrites act as independent computational subunits within a multilayered processing scheme. However, when a PN is strongly activated, back-propagating action potentials (bAPs) sweeping outward from the soma synchronize dendritic membrane potentials many times per second. How PN dendrites maintain the independence of their voltage-dependent computations, despite these repeated voltage resets, remains unknown. Using a detailed compartmental model of a layer 5 PN, and an improved method for quantifying subunit independence that incorporates a more accurate model of dendritic integration, we first established that the output of each dendrite can be almost perfectly predicted by the intensity and spatial configuration of its own synaptic inputs, and is nearly invariant to the rate of bAP-mediated "cross-talk" from other dendrites over a 100-fold range. Then, through an analysis of conductance, voltage, and current waveforms within the model cell, we identify three biophysical mechanisms that together help make independent dendritic computation possible in a firing neuron, suggesting that a major subtype of neocortical neuron has been optimized for layered, compartmentalized processing under in-vivo-like spiking conditions.
FOXK2 promotes ovarian cancer stemness by regulating the unfolded protein response pathway (2022)

Understanding the regulatory programs enabling cancer stem cells (CSCs) to self-renew and drive tumorigenicity could identify new treatments. Through comparative chromatin-state and gene expression analyses in ovarian CSCs versus non-CSCs, we identified FOXK2 as a highly expressed stemness-specific transcription factor in ovarian cancer. Its genetic depletion diminished stemness features and reduced tumor initiation capacity. Our mechanistic studies highlight that FOXK2 directly regulated IRE1α (encoded by ERN1) expression, a key sensor for the unfolded protein response (UPR). Chromatin immunoprecipitation and sequencing revealed that FOXK2 bound to an intronic regulatory element of ERN1. Blocking FOXK2 from binding to this enhancer by using a catalytically inactive CRISPR/Cas9 (dCas9) diminished IRE1α transcription. At the molecular level, FOXK2-driven upregulation of IRE1α led to alternative XBP1 splicing and activation of stemness pathways, while genetic or pharmacological blockade of this sensor of the UPR inhibited ovarian CSCs. Collectively, these data establish what we believe is a new function for FOXK2 as a key transcriptional regulator of CSCs and a mediator of the UPR, providing insight into potentially targetable new pathways in CSCs.
Fellowship To Study the Involvement of Heat Shock Proteins in Drug Resistance in Human Breast Cancer. (1996)

Heat shock proteins (hsps) are induced in cells in response to environmental stresses. It has been shown that breast cancer cells sometimes express high levels of hsp27, which may augment the aggressiveness of these tumors and make them more resistant to treatment. This study was designed to determine the role of hsp27 in resistance to specific chemotherapeutic drugs, and to begin dissecting the regulation of hsp27 in human breast cancer cells. Toward this goal, we proposed the following specific aims: (1) Examine the regulatory mechanisms underlying the expression of hsp27 in breast cancer cell lines and human breast tumors. (2) Identify genes whose expression is associated with hsp27 effects on proliferation and drug resistance, as well as proteins interacting directly with hsp27. (3) Target positive and negative hsp27 transcriptional regulatory factors identified in Aims 1 and 2 to interfere with hsp27 expression. (Years 2-3). The work addressing Aim 1, carried out in our laboratory between 30 January 1995 to 30 January 1996 is the subject of this report. The first year of investigation was spent addressing specific aim 1. As discussed in the grant, we cloned the hsp27 promoter region and identified a broad area involved in basal transcription and a negative response region by deletion mapping.
Measurement and Analysis of the Extreme Physical Shock Environment Experienced by Crane-Mounted Radiation Detection Systems (2019)

At ports of entry, radiation detectors could be mounted on container gantry crane spreaders to monitor cargo containers entering and leaving the country. These detectors would have to withstand the extreme physical conditions experienced by these spreaders during normal operations. Physical shock data from the gable ends of a spreader were recorded during the loading and unloading of a cargo ship by two hard mounted PCB Piezotronics model 340A50 accelerometers and two Lansmont SAVER 9X30 units (with padding). The majority of large shocks were observed in the vertical direction. The Lansmont units recorded mean shocks of 22.215 ± 1.174 and 23.776 ± 1.140 g, while the PCB accelerometers recorded mean shocks of 31.608 ± 1.798 and 37.072 ± 2.015 g in this direction. Maximum shocks were as high as 118.854 g. A scatter plot of observed peak acceleration versus velocity change is presented to allow comparison with the damage boundary curve for any planned instrumentation for future systems. It is hoped that the results of this research will aid in the design of future crane-mounted systems.
Diurnal Variation in Insulin Sensitivity of Glucose Metabolism Is Associated With Diurnal Variations in Whole-Body and Cellular Fatty Acid Metabolism in Metabolically Normal Women (2014)

Metabolically normal women demonstrate diurnal variations in fatty acid metabolism, manifested by an increase in circulating FFAs, presumably derived from previous meal consumption rather than lipolysis of adipose tissue triglycerides, and a shift in muscle fatty acid metabolism from oxidation to lipogenesis. These metabolic alterations could be responsible for the known evening decline in insulin sensitivity.
Highly Enantioselective Construction of Polycyclic Spirooxindoles by Organocatalytic 1,3‐Dipolar Cycloaddition of 2‐Cyclohexenone Catalyzed by Proline‐Sulfonamide (2014)

Abstract The enantioselective 1,3‐dipolar cycloaddition of 2‐cyclohexene‐1‐one and azomethine ylides generated in situ from isatins and amino esters was developed by employing prolinosulfonamides as the catalyst. Consequently, novel polycyclic spirooxindole scaffolds with three contiguous stereocenters were prepared in high yield (up to 95 %) with excellent diastereo‐ (&gt;20:1 dr ) and enantioselectivity (up to 99 % ee ).
A grape seed extract maternal dietary supplementation improves egg quality and reduces ovarian steroidogenesis without affecting fertility parameters in reproductive hens (2020)

In broiler hens, the genetic selection increased susceptibility to metabolic disorders and reproductive dysfunctions. In human ovarian cells, grape seed extracts (GSE) improved steroid production. Here, we investigated the effects of a GSE dietary supplementation on egg production and quality, fertility parameters, Reactive Oxygen Species (ROS) and steroid content in yolk egg associated to plasma adipokines in broiler hens. For this, we designed two in vivo experiments, the first one included three groups of hens: A (control), B and C (supplemented with GSE at 0.5% and 1% of the total diet composition, respectively, since week 4), and the second one used two groups of hens: A (control) and D (supplemented with GSE at 1% of the total diet composition since hatching). We assessed the egg production from 23th to 40th weeks and quality at 33th week. After artificial inseminations, the fertility parameters were calculated. In egg yolk, Reactive Oxygen Species (ROS) level and steroid production were evaluated by Ros-Glo H202 and ELISA assay, respectively. Expression of steroidogenic enzymes and adipokines and their receptors was determined by RT-qPCR in ovarian cells and plasma adipokines (RARRES2, ADIPOQ and NAMPT) were evaluated by specific ELISA assays. The fertility parameters and egg production were unaffected by GSE supplementation whatever the experiment (exp.). However, the rate of double-yolk eggs decreased for all GSE supplemented groups (exp. 1 P <0.01, exp.2, P<0.02). In exp.1, C group eggs were bigger and larger (P<0.0001) and the shell elasticity was higher for both B and C (P<0.0003) as compared to control. In the egg yolk, GSE supplementation in both exp. reduced ROS content and steroidogenesis consistent with a decrease in P450 aromatase and StAR mRNA expression and basal in vitro progesterone secretion in granulosa cells (P<0.001). Interestingly, in both exp. RARRES2 plasma levels were positively correlated while ADIPOQ and NAMPT plasma levels were negatively correlated, with steroids and ROS in yolk (P<0.0001). Taken together, maternal dietary GSE supplementation did not affect egg production and fertility parameters whereas it reduced ROS content and steroidogenesis in yolk egg. Furthermore, it ameliorated egg quality by decreasing the number of double-yolk eggs and by improving the size of normal eggs and the elasticity of the shell. Taken together, our data suggest the possibility of using dietary maternal GSE to improve egg quality.
Evolution of Wireless Sensor Networks for Industrial Control (2013)

IntroductionComparisons between the two standards for wireless sensor networks (WSN) for industrial instrumentation and control commonly view WirelessHART (WH) and ISA100.11a (ISA) as competing standards, and they tend to conclude that one standard is better than the other. Consider the titles of recent comparisons in two widely read industry trade journals: “WirelessHART Wins
The Effects of Housing Design on the Feeding Behaviors of Group Housed Pregnant Sow with Electronic Sow Feeder (2014)

This study was conducted to evaluate the housing design on the feeding behaviors of group housed pregnant sows. A total of 65 sows (Landrace <TEX>${\times}$</TEX> Yorkshire) were employed into 2 experimental sow housing with different housing design. Lying area of one of sow housing was designed with concrete fence to give the shelter for weak sows. The other was floor type without any obstacles. Group housed sows were fed using electronic sow feeder (ESF) during gestation. Daily feeding pattern of sows was automatically recorded in ESF feeder program. Most sows ate all feed during night. Daily visiting frequency to ESF of sows in pig pen with the shelter was significantly lowered than sows in floor type pen. This study showed that the housing design of group housed sow pen could fairly impact ESF utilization of sow.
Large Effective-Area Few-Mode Multicore Fiber (2012)

A design concept of few-mode multicore fiber is presented. Cores with a step-index profile are designed to support two LP modes over the C band and the L band with a large effective area larger than 110 μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The pitch of cores is determined regarding the inter-core crosstalk related to the LP <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">11</sub> mode. The two LP modes multicore fibers with four cores and seven cores show a relative core multiplicity factor (RMCF) of 7.3 and 9.2, respectively. The RCMF of the proposed two LP modes multicore fiber is larger than that of previously reported single-mode multicore fibers.
The chemistry of 5,6,7,12-tetrahydro-5,7-dioxo-N-phenyldibenz[b,g]azocine: a new entry in the dibenz[b,g]azocine class (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe chemistry of 5,6,7,12-tetrahydro-5,7-dioxo-N-phenyldibenz[b,g]azocine: a new entry in the dibenz[b,g]azocine classJohn L. Fox, Chin H. Chen, and Henry R. LussCite this: J. Org. Chem. 1987, 52, 14, 2980–2983Publication Date (Print):July 1, 1987Publication History Published online1 May 2002Published inissue 1 July 1987https://pubs.acs.org/doi/10.1021/jo00390a005https://doi.org/10.1021/jo00390a005research-articleACS PublicationsRequest reuse permissionsArticle Views199Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Adhesive wafer bonding for CMOS based lab-on-a-chip devices (2019)

Abstract Adhesive wafer bonding using laminated photosensitive dry-resist offers many advantages and can be used to realize advanced, CMOS integrated, lab-on-a-chip devices. The low bond-temperatures involved allow the hybrid integration of a range of substrates, e.g. CMOS wafers with structured MEMS glass wafers. The dry-film polymer functions as an adhesive interlayer and can be lithographically patterned to form sealed microfluidic fluid channels and chambers. This approach is well suited for low-cost R&amp;D prototyping, and efforts reported in the past were often limited to proof-of-concept devices. However, all of the involved process steps do have the potential to be scaled up for an industrial volume production. We report on our activities to implement a baseline 8″ process flow, using the ORDYL SY300 series of permanent dry-film resist, to enable the commercial manufacturing of microfluidic devices based on this technology at a MEMS foundry. Advantages and disadvantages of the presented approach are discussed.
A Hyperprior Bayesian Approach for Solving Image Inverse Problems (2014)

Patch models have proven successful to solve a variety of inverse problems in image restoration. Recent methods, combining patch models with a Bayesian approach, achieve state-of-the-art results in several restoration problems. Dif-ferent strategies are followed to determine the patch mod-els, such as a fixed number of models to describe all im-age patches or a locally determined model for each patch. Local model estimation has proven very powerful for im-age denoising, but it becomes seriously ill-posed for other inverse problems such as interpolation of random missing pixels or zooming. In this work, we present a new frame-work for image restoration that combines these two power-ful approaches: Bayesian restoration and a local charac-terization of image patches. By making use of a prior on the model parameters, we overcome the ill-posedness of the local estimation and obtain state-of-the-art results in prob-lems such as interpolation, denoising and zooming. Exper-iments conducted on synthetic and real data show the effec-tiveness of the proposed approach.
Modified soybean oil as a reactive diluent: Synthesis and characterization (2014)

ABSTRACT Soybean oil was modified in two steps: (1) conjugation of soybean oil and (2) Diels‐Alder addition with 3‐(trimethoxysilyl)propyl methacrylate, 2,2,2‐trifluoroethyl methacrylate and triallyl ether acrylate. The structures were characterized using 1 H NMR, 13 C NMR, 13 C‐ 1 H gradient heteronuclear single quantum coherence (gHSQC) NMR spectroscopy, and MALDI‐TOF mass spectrometry. The 13 C‐ 1 H gHSQC NMR spectra helped confirm the formation of a cyclohexene ring in all reactions, indicating a Diels‐Alder addition. The diluent efficiency of modified soybean oil was evaluated in long oil alkyd formulation. Triallyl ether functionalized soybean oil resulted in the highest reduction in the viscosity of the alkyd formulations. © 2014 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2014 , 52 , 3045–3059