gebhart/patrepeval huggingface dataset:
Impact of Achieved Blood Pressure on First Stroke in Uncomplicated Grade 1 Hypertension (2017)

Achieved BP <140/90 mm Hg was significantly associated with a decreased risk of stroke or all-cause death in patients with uncomplicated grade 1 hypertension.
Pheromonal Production of and Response to Optically Active Epoxydienes in Some Geometrid Moths (Lepidoptera: Geometridae) (1994)

In pheromone extracts of calling female Chiasma clathrata L. (Lepidoptera: Geometridae), a defoliator pest of alfalfa, (Z,Z,Z)-3,6,9-heptadecatriene and (Z,Z)-6,9-cis-3,4-epoxyheptadecadiene was identified. Chiral gas chromatography using a modified cyclodextrin and synthetic reference samples proved the natural epoxide to show (3R, 4S)-configuration. In field trapping tests, only the pure (3R, 4S)-enantiom er of the epoxide attracted males. The addition of the triene component was synergistic. Males of the sympatric species Tephrina arenacearia Hbn. (Lepidoptera: Geometridae) were caught only in traps with baits containing the (3S, 4R)-enantiomer [together with a previously described minor component, (Z,Z)-3,9-cis- 6,7-epoxyheptadecadiene]. In trapping tests conducted in a different biotope, Abraxas grossulariata L. (Lepidoptera: Geometridae) males were attracted by the (3S, 4R)-enantiomer, whereas the (3R, 4S)-enantiomer attracted a close relative, Abraxas sylvata Scop. (Lepidoptera: Geometridae). The present results suggest that one of the key mechanisms responsible for pheromone specificity among both the two alfalfa geometrids and the two A braxas species in their respective biotops, may be the use of different enantiomers of the same polyenederived epoxide as a sex pheromone component. It is probable that this discrimination mechanism is widespread among moth species utilizing epoxide pheromone components
Controlled Delivery of MicroRNAs into Primary Cells Using Nanostraw Technology (2021)

MicroRNAs (miRNAs) are small noncoding RNAs that play key roles in post- transcriptional gene regulation. Being involved in regulating virtually all cellular processes, from proliferation and differentiation to migration and apoptosis, they have emerged as important epigenetic players. While most interest has gone into which miRNAs are involved in specific cellular processes or pathologies, the dosage-dependent effects of miRNAs remain vastly unexplored. Different doses of miRNAs can cause selective downregulation of target genes, in turn determining what signaling pathways and cellular responses are triggered. To explore this behavior, the effects of incremental miRNA dosage need to be studied; however, current delivery methods for miRNAs are unable to control how much miRNA enters a cell. Herein, an approach is presented based on a nanostrawelectroporation delivery platform that decouples the delivery from biological mechanisms (e.g., endocytosis) to enable precise control over the amount of miRNA delivered, along with demonstrating ratiometric intracellular delivery into primary dermal fibroblasts for miR-181a and miR-27a. In addition, it is shown that the nanostraw delivery platform allows efficient delivery of miRNAs into primary keratinocytes, opening new opportunities for successful miRNA delivery into this hard-to-transfect cell type.
Digital images and human vision (1994)

Processing of digital images destined for visual consumption raises many interesting questions regarding human visual sensitivity. This talk will survey some of these questions, including some that have been answered and some that have not. There will be an emphasis upon visual masking, and a distinction will be drawn between masking due to contrast gain control processes, and due to processes such as hypothesis testing, pattern recognition, and visual search.
Distributed optimization of the Bhattacharyya parameter in wireless relay networks (2011)

A distributed optimization algorithm is presented for resource allocation in wireless relay networks. This algorithm is particularly useful in multiple-source, multiple-relay wireless networks employing fractional cooperation, in which each relay contributes only a fraction of its resources to each source; in this case, the algorithm is used to find the optimal fractions. The advantage of this distributed algorithm is to permit optimization in a large network, even though each node is only aware of the local topology of the network. Examples and simulation results are presented, illustrating the use of this algorithm.
Caste (1858)

Journal Article Caste Get access A. C. M. A. C. M. Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s2-VI, Issue 135, 31 July 1858, Page 98, https://doi.org/10.1093/nq/s2-VI.135.98a Published: 31 July 1858
Th1 and Th17/Treg-rebalancing by Small Molecule Natura-α Shows Great Promise Against Ulcerative Colitis in a Randomized, Double-blind, Placebo-controlled Phase II Clinical Trial (2011)

Purpose: Inflammatory bowel diseases, ulcerative colitis (UC) and Crohn's disease, are thought to result from an aberrant intestinal immune response - specifically, disequilibrium between regulatory T cells (Treg) and pro-inflammatory Th17 cells. Natura-α, a synthetic small molecule, re-establishes immune system homeostasis by decreasing IL-6 and Th17 cells while increasing Treg. This Phase 2 study assessed the safety and efficacy of two dose levels of Natura-α in patients with active UC treated for 28 days. Methods: This was a randomized, double-blind, placebo-controlled study at 10 U.S. clinical centers recruiting 67 patients with moderate to severe ulcerative colitis defined as: Disease Activity Index (DAI) score of 6 to 10 (inclusive); endoscopic evidence of active UC (mucosal appearance score of ≥2) by flexible sigmoidoscopy; rectal bleeding (DAI sub score of ≥1); and Physician's Global Assessment (PGA score ≥2). Patients were randomized in equal proportion to placebo, 10 mg or 20 mg Natura-α administered orally twice daily for 28 days. Assessments were made at baseline and after 7, 14 and 28 days of treatment with off-treatment follow-up at days 35 and 56. Efficacy was defined as: Clinical response: Improvement in the PGA score by at least one class and improvement in the mucosal appearance score by at least one class and no worsening in any other scores; Significant clinical response: Reduction of the DAI score either by at least 5 points or by at least 75% and improvement in mucosal appearance score by at least one class and no worsening in any other scores; and Clinical remission: Clinically symptom free after treatment (DAI or PGA score equal to zero). Safety laboratory and adverse events were monitored for the duration of the study. Results: Clinical response, significant clinical response and clinical remission is 76.0%, 40.0%, and 18.0%, respectively, based on blinded pooled data from the three treatment groups (completed data with statistical analysis for individual groups will be available at the meeting). The majority of adverse events were mild to moderate in severity and no serious adverse events related to Natura-α treatment were reported. Conclusion: This short duration clinical trial provides evidence that Natura-α shows great promise for treatment of moderate to severe ulcerative colitis. All categories of clinical response were improved and the drug was well tolerated. This novel small molecule appears to act by reestablishing the balance between Treg and Th1/Th17 cells and may address a fundamental mechanism of immune-mediated disease. Disclosure: Dr. Sartor - Consultant: Natrogen Therapeutics International. Mr. Mencher and Dr. Wang: Employee: Natrogen Therapeutics International, Inc. This research was supported by an industry grant from Natrogen Therapeutics International, Inc.
Imaging assessment of osteoid osteoma (2009)

Objective To assess the diagnostic value of DR,SCT,MSCT and MRI in diagnosis of osteoid osteoma.Methods Nineteen cases of osteoid ostcoma proved by surgical pathology were collected,Among the 19 cases,all patients had DR and CT scanning,8 with MR imaging.All the DR image processing were performed to display the nidus.Ten patients were examined by SCT axial scanning and 9 cases were performed by MSCT using isotropic parameters,then multi-direction MPR were performed.The ability of DR,SCT,MSCT and MKI in demonstrating the nidus and the surrounding reaction were analyzed.Results Among 19 cases.only 6 cases showed nidus on DR before image processing and 12 showed nldus after image processing.All cases with CT scanning showed nidus.Among 8 cases with MRI.only 6 eases could be diagnosed correedy.The nldns could be ariarmed in only 4 cases.and the nidus was affirmed by comparing with DR or CT in 2 eases,the other 2 cases were misdiagnosis.Among 10 eases with SCT,only 6 cases showed calcification of nidus.Whereas among 9 cases with MSCT,8 cases showed calcification of nidus.There were also soft tissue and bone marrow edema around the nidus on MR imaging in all 8 cases.Conclusion Nidm is the key in diagnosing the osteoid osteoma correctly.DR is a basic checking method for osteoid osteoma.DR image processing con improve the display rates of nidus.CT scan is the best method to demonstrate the nidus.MSCT is better than SCT in demonstrating the nidus and the surrounding reaction.MRI can demonstrate the soft tissue and bone marrow edema around the nidus sensitively.but probably lead to an incorrect diagnosis.Combining with DR or CT.MRI can make an accurate diagnosis.

Key words: 
Osteoma,osteoid; Radiography; Tomography,X-ray computed; Magnetic resonance imaging
Spectral analysis of synthetic electrode activations in adaptive capacitance volume tomography (2016)

Different synthetic electrode configurations are investigated for use in adaptive electrical capacitance volume tomography. We evaluate in particular the spectrum of singular values of the resulting sensitivity matrix as a function of the set of activated electrode to seek optimal arrangements that maximize the information content provided by a fixed number of measurement acquisitions (or acquisition speed). We also briefly discuss the impact of these factors on the resolution of the reconstructed images.
Type 1 Diabetes and Multiple Sclerosis (2003)

Last year, Marrosu et al. (1) reported an increased prevalence of type 1 diabetes among Sardinian individuals with multiple sclerosis and their first-degree relatives. The study was accompanied by a commentary (2) indicating that these autoimmune disorders were “an unlikely alliance” because the HLA haplotype that increases risk for multiple sclerosis (DRB1\*15-DQA1\*0102-DQB1*0602) protects against type 1 diabetes. To the authors’ knowledge, there have been no published studies of an increased risk of multiple sclerosis for individuals with type 1 diabetes or their families.

Could the association between type 1 diabetes and multiple sclerosis be unique to Sardinia, where the rates of these two disorders are among the highest in the …
<title>Visual search engine for product images</title> (2007)

Nowadays there are many product comparison web sites. But most of them only use text information. This paper introduces a novel visual search engine for product images, which provides a brand-new way of visually locating products through Content-based Image Retrieval (CBIR) technology. We discusses the unique technical challenges, solutions, and experimental results in the design and implementation of this system.
AN ELEMENTARY TREATMENT OF THE MOTION OF A SPINNING PROJECTILE ABOUT ITS CENTER OF GRAVITY (1944)

A spin is imparted to most artillery projectiles to prevent their tumbling. It is of interest in designing projectiles and the rifling of cannon to know what spin is required to produce a stable motion of the projectile about its center of gravity. The object of this paper is to provide simply and clearly the theoretical basis for the estimation of the required spin and to describe analytically the motion of a yawing, spinning projectile.
Germination and Growth Inhibitors in Guayule (Parthenium argentatum Gray) Chaff and Their Possible Influence in Seed Dormancy (1982)

Guayule (Parthenium argentatum Gray) is a rubber-producing plant native to the semi-arid region of north central Mexico and southwestern Texas. As a member of the family Asteraceae, the seed dispersal unit in guayule is comprised of an achene enclosed by two staminate florets and a bract. The seeds in this condition are dormant and need special treatment in order to germinate. Threshing, prolonged washing, and/or chemical treatments prove effective in improving the germination. Experiments showed that chaff influenced germination and seedling emergence. Bioassays of aqueous extracts of guayule chaff and the seed coat showed a significant inhibition of germination and radicle growth of guayule, lettuce, and tomato seeds. High-performance liquid chromatography enabled the identification of at least seven phenolic acids from guayule chaff extract. These, in order of decreasing concentrations, included p-hydroxybenzoic, protocatechuic, p-coumaric, ferulic, benzoic, vanillic, and cinnamic acids. All of them are well-known germination and growth inhibitors, and seem to play an important role in the dormancy of guayule seed.
Entropy and Gaussianity - Measures of Deterministic Dynamics of Heart Rate and Blood Pressure Signals of Rats (2007)

Heart rate and blood pressure short-term variability analysis represent promising quantitative measures of the cardiovascular autonomic controls. The analysis includes traditional statistical analytical tools and a number of methods based on nonlinear system theory, recently developed to give better insight into complex HR and BP time series. These methods might reveal abnormalities that may not be uncovered by traditional measures. This paper investigates the measure of entropy of HR and BP time series as a consequence of the involvement of the autonomic nervous system, assessed in conscious telemetred rats under blockade of β-adrenergic, α-adrenergic and M-cholinergic receptors.
Spare Receptors for β-Adrenoceptor-Mediated Positive Inotropic Effects of Catecholamines in the Human Heart (1992)

We studied whether the human heart has spare receptors for beta-adrenoceptor-mediated positive inotropic effects. Thus, we assessed in right atria and left papillary muscles of patients with different degrees of heart failure under identical experimental conditions affinity (pKI values from (-)-[125I]iodocyanopindolol binding) and potency (pD2 values from contractile responses) for isoprenaline, adrenaline, and noradrenaline in comparison with rat heart. Plots of beta-adrenoceptor occupancy versus responses constructed from these data revealed that rat left atria and papillary muscles had a large receptor reserve for all three beta-adrenoceptor agonists: 50% of maximal response was produced with only 1-3% of beta-adrenoceptor occupancy. In human heart, however, receptor reserve was considerably lower: 50% of maximal response required 8-10% (in right atria) and 20-25% (in left papillary muscles) occupation of beta-adrenoceptors. Receptor reserve declined further with an increasing degree of heart failure (and decreasing beta-adrenoceptor number): in end-stage heart failure (New York Heart Association class IV) both in right atria and left papillary muscles a 1:1 ratio between beta-adrenoceptor occupancy and responses was observed. These data show that the human heart has only a small receptor reserve for beta-adrenoceptor agonists. This may explain why a decrease in beta-adrenoceptor number leads to a decrease in beta-adrenoceptor function early in the development of heart failure.
Training and Mentoring the Next Generation of Scientists and Engineers to Secure Continuity and Successes of the US DOE's Environmental Remediation Efforts - 13387 (2013)

The DOE Office of Environmental Management (DOE-EM) oversees one of the largest and most technically challenging cleanup programs in the world. The mission of DOE-EM is to complete the safe cleanup of the environmental legacy from five decades of nuclear weapons development and government-sponsored nuclear energy research. Since 1995, Florida International University’s Applied Research Center (FIU-ARC) has supported the DOE-EM mission and provided unique research capabilities to address some of these highly technical and difficult challenges. This partnership has allowed FIU-ARC to create a unique infrastructure that is critical for the training and mentoring of science, technology, engineering, and math (STEM) students and has exposed many STEM students to “hands-on” DOE-EM applied research, supervised by the scientists and engineers at ARC. As a result of this successful partnership between DOE and FIU, DOE requested FIU-ARC to create the DOE-FIU Science and Technology Workforce Development Initiative in 2007. This innovative program was established to create a “pipeline” of minority STEM students trained and mentored to enter DOE’s environmental cleanup workforce. The program was designed to help address DOE’s future workforce needs by partnering with academic, government and private companies (DOE contractors) to mentor future minority scientists and engineers in the research, development, and deployment of new technologies and processes addressing DOE’s environmental cleanup challenges. Since its inception in 2007, the program has trained and mentored 78 FIU STEM minority students. Although, the program has been in existence for only five years, a total of 75 internships have been conducted at DOE National Laboratories, DOE sites, DOE Headquarters and field offices, and DOE contractors. Over 85 DOE Fellows have participated in the Waste Management Symposia since 2008 with a total of 68 student posters and 7 oral presentations given at WM. The DOE Fellows participation at WM has resulted in three Best Student Poster Awards (WM09, WM10, and WM11) and one Best Professional Poster Award (WM09). DOE Fellows have also presented their research at ANS DD&R and ANS Robotics Topical meetings. Moreover, several of our DOE Fellows have already obtained employment with DOE-EM, other federal agencies, DOE contractors.
Indications, technique, and pitfalls of reverse total shoulder arthroplasty for proximal humerus fractures. (2013)

Latina women and other ethnic and racial groups continue to be underrepresented in science, technology, engineering, and mathematics (STEM) fields, including public health. This underrepresentation of people from diverse backgrounds and lived experiences in academic public health and other scientific disciplines is a form of epistemic oppression, exclusion that hinders contribution to knowledge production and advancement. Our analysis of 2021 data from the Association of Schools and Programs of Public Health indicates that Latinos/as represented only 6.0% of all instructional faculty and 6.1% of all tenured faculty at schools and programs of public health. We discuss the ways in which sociopolitical contexts, family-level dynamics and gendered norms, and institutional contexts hamper Latinas' full participation in academia. We propose solutions such as redefining metrics for success, leadership accountability, equity analyses, cluster hiring initiatives, and instituting structured mentoring and leadership programs. Bold actions are needed if we are to advance the scientific enterprise and address the diversity and equity problem in public health.
Formal modelling and verification of a component model using coloured petri nets and model checking (2007)

Component based software engineering has been claimed as a suitable approach to improve the flexibility and reuse in software development. In this context, the Compor infrastructure provides mechanisms to promote the dynamic composition of software systems, addressing applications with support for unanticipated requirement changes. In this paper, the formal modelling and verification of the COMPOR component model is presented. Hierarchical Colored Petri Nets are used for modelling and simulation, purposing to show the correct behavior for some scenarios. Model checking is used to prove that the scenarios analyzed with simulation are correct for all possible behaviors of the model.
Circadian clock in cell culture: I. Oscillation of melatonin release from dissociated chick pineal cells in flow-through microcarrier culture (1988)

The avian pineal gland contains circadian oscillators that regulate the rhythmic release of melatonin. We have developed a dissociated chick pineal cell culture system in order to begin a cellular analysis of this vertebrate circadian oscillator. Dissociated pineal cells maintained in cyclic light conditions (LD 12:12) released melatonin rhythmically. The release of melatonin was elevated during the dark and low during the light. A circadian oscillation of melatonin release persisted for at least 5 cycles in constant darkness with a period close to 24 hr; however, there was a gradual damping of the amplitude. Analysis of the rhythm revealed that the observed damping was consistent with either desynchronization of multiple oscillators within the cultures or damping of individual oscillators. The circadian oscillation of melatonin release persisted for up to 4 cycles under conditions of constant light; however, the oscillation was strongly damped and the period of the oscillation was lengthened significantly. Thus, dissociated pineal cells express a persistent circadian oscillation of melatonin release in constant darkness, and properties of this oscillation are modulated by light treatment in vitro. This flow-through cell culture method for dissociated chick pineal cells should provide a useful model for the analysis of a vertebrate circadian system at the cellular level.
Revolutionary all-organic composite ferroelectric-relaxor P(VDF-TrFE-CFE) for low electric field actuators (2014)

International audience
Differential transcriptional profiles mediated by exposure to the cannabinoids cannabidiol and Δ9‐tetrahydrocannabinol in BV‐2 microglial cells (2011)

This article is part of a themed section on Cannabinoids in Biology and Medicine. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2012.165.issue-8. To view Part I of Cannabinoids in Biology and Medicine visit http://dx.doi.org/10.1111/bph.2011.163.issue-7.
Establishing the dosage equivalency of oxymorphone extended release and oxycodone controlled release in patients with cancer pain: a randomized controlled study (2004)

Adult patients with cancer who were taking oxycodone CR were readily converted to oxymorphone ER and required half the milligram dose to stabilize their pain. Within 72 h, most patients achieved a stable dose that provided adequate relief with similar opioid adverse events.