gebhart/patrepeval huggingface dataset:
Superspeed Traveling Wave Magnetic Particle Imaging (2015)

Since the first publication in 2005, several different scanner types for magnetic particle imaging (MPI) have been presented. One of these scanner concepts is traveling wave MPI (TWMPI). It uses a dynamic linear gradient array, which generates and moves a field free point with a strong gradient, which is necessary for scanning the sample in 3-D. Due to the linear properties of the TWMPI device, very fast 2-D imaging with frame rates higher than 1500 frames/s is possible (superspeed mode). Using the superspeed mode different high speed measurements are conceivable, e.g., fluid-dynamic investigations.
Predictors of medication adherence in patients with schizophrenia and bipolar disorder (2012)

Substance use is an important risk factor for non-adherence in patients with schizophrenia and bipolar disorder. Poor insight is also a risk factor in schizophrenia. The results suggest that cognitive dysfunction is not a risk factor for non-adherence in these diagnostic groups.
Hyalinizing Pancreatic Adenocarcinoma in Six Dogs (2008)

Exocrine pancreatic carcinoma is a particularly malignant neoplasm of the dog. Clinical and pathologic findings of an unusual variant of exocrine pancreatic neoplasia termed hyalinizing pancreatic adenocarcinoma were evaluated in 6 dogs. On microscopic examination, neoplasms were composed of tubules and acini of epithelial cells, with bright eosinophilic granular apical cytoplasm. Tubular lumina and tumor stroma contained abundant hyaline material that resembled amyloid. The hyaline material was not congophilic, and tumor cells and hyaline material were immunohistochemically negative for amyloid A, immunoglobulin light chains (kappa and lambda), amylin (islet amyloid polypeptide), laminin, and alpha(1)-antitrypsin. Two patients survived longer than 15 months after diagnosis; one of these dogs was untreated and had grossly evident metastasis at the time of diagnosis. The deaths of the other 4 dogs occurred as a result of poor recovery after partial pancreatectomy or in association with other concurrent life-threatening conditions. Two dogs were diagnosed with panniculitis, a condition rarely associated with pancreatic disease. Further evaluation is needed to determine the composition and biologic significance of intratumor hyaline material. Studies that associate exocrine pancreatic carcinoma grade and histologic subtype with prognostic outcomes in the dog are warranted such that appropriate therapy can be elected.
Activation and Inhibition of the EGF Receptor (2007)

The epidermal growth factor (EGF) receptor is the prototype of the ErbB (Her) family receptor tyrosine kinases (RTKs), which regulate cell growth and differentiation and are implicated in many human cancers. EGF activates its receptor (EGFR) by inducing dimerization of the 621 amino acid EGFR extracellular region. I will describe our current mechanistic view of EGF‐induced dimerization and activation of EGFR based on crystallographic and other studies. I will also describe how studies of the EGFR orthologs from D. melanogaster and C. elegans help in translating lessons learned with isolated extracellular domains to the cell surface. Invertebrates have evolved several mechanisms to inhibit signaling by their EGFR orthologs that have not been described in mammals. The secreted molecule Argos acts as a ‘ligand sink’ that effectively neutralizes EGFR‐activating ligands. Kekkon‐1 is a membrane protein that interacts directly with (and inhibits) EGFR. I will discuss our current studies of inhibition of EGFR signaling through these mechanisms, which offer lessons for the design of novel EGFR‐targeted therapeutic strategies in humans.
In vivo oxygen transport in the normal rabbit femoral arterial wall. (1980)

In vivo measurements of tissue oxygen tension were made at 10-micrometer intervals through functioning in situ rabbit femoral arterial walls, using inhalation anesthesia and recessed microcathodes with approximately 4-micrometer external diameters. External environment was controlled with a superfusion well at 30 torr PO2, 35 torr PCO2. Blood pressure, gas tension levels, and blood pH were held within the normal range. Radial PO2 measurements closely fit a mathematical model for unidimensional diffusion into a thick-walled artery with uniform oxygen consumption, and the distances traversed fit measured dimensions of quick-frozen in vivo sections. Using standard values of diffusion and solubility coefficients, mean calculated medial oxygen consumption was 99 nl0/ml-s. Mural oxygen consumption appeared to be related linearly to mean tangential wall stress. Differences in experimental design and technique were compared with previous in vivo and in vitro measurements of wall oxygenation, and largely account for the varying results obtained. Control of environment external to the artery, and maintenance of normally flowing blood in the lumen in vivo appeared critical to an understanding of mural oxygenation in life. If the conditions of this experiment prevailed in arteries with thicker avascular layers, PO2 could have been 20 torr at approximately 156 micrometer and 10 torr at 168 micrometer from blood (average values).
Energy efficiency in SMEs: overcoming the communication barrier (2020)

Abstract This article discusses ineffective knowledge and information communication as an important barrier to improving energy efficiency in small and medium-sized enterprises (SMEs) and considers how to make functional communication an enabler of future SME energy-efficiency programmes. Energy audits – important tools when addressing energy efficiency in companies – are often performed by professionals with an engineering background, which does not reflect the backgrounds of those receiving the audit, inhibiting the interpretation of those audits. SMEs must actively process the information, and their employees must be able to connect the information to existing knowledge. We analysed two methods used by Swedish municipal energy-efficiency programmes to improve energy efficiency in SMEs. The results indicate that in the programme providing SMEs with third-party information, but without any possibility to process the information, the energy-efficiency results were poor, while in the programme in which SMEs were actively engaged in all stages and could discuss problems and results with peers, the energy-efficiency results were better. In implementing SME energy-efficiency programmes, municipalities should avoid simply offering audits. Instead, they should find methods that facilitate knowledge creation among the participants, allowing the participating SMEs to share experience and knowledge with one another and with experts, and to take home ideas, testing them in their own contexts, and communicating their experiences. This would be a way to make communication an enabler rather than a barrier.
Chemical gaseous treatment of SnO 2 for a selective detection of gas (1983)

Heated at 500°C under a SO 2 air mixture, tin dioxide is sensitized for different gaseous compounds. Selective detector devices can be imagined with sensor heated at different temperatures or with sensors with time programmed cycliing temperature. An interpretation of the electrical phenomenon based on a potential barrier effect associated with a chemical reaction process is proposed.
Direct nitration of five membered heterocycles (2005)

Direct nitration of a variety of furans, pyrroles, thiophenes, pyrazoles, imidazoles, isoxazoles and thiazoles (17 compounds) with nitric acid/trifluoroacetic anhydride affords mononitro derivatives in average yield of 60 %.
Stable recursive auxiliary field quantum Monte Carlo algorithm in the canonical ensemble: Applications to thermometry and the Hubbard model (2023)

Many experimentally accessible, finite-sized interacting quantum systems are most appropriately described by the canonical ensemble of statistical mechanics. Conventional numerical simulation methods either approximate them as being coupled to a particle bath or use projective algorithms which may suffer from nonoptimal scaling with system size or large algorithmic prefactors. In this paper, we introduce a highly stable, recursive auxiliary field quantum Monte Carlo approach that can directly simulate systems in the canonical ensemble. We apply the method to the fermion Hubbard model in one and two spatial dimensions in a regime known to exhibit a significant "sign" problem and find improved performance over existing approaches including rapid convergence to ground-state expectation values. The effects of excitations above the ground state are quantified using an estimator-agnostic approach including studying the temperature dependence of the purity and overlap fidelity of the canonical and grand canonical density matrices. As an important application, we show that thermometry approaches often exploited in ultracold atoms that employ an analysis of the velocity distribution in the grand canonical ensemble may be subject to errors leading to an underestimation of extracted temperatures with respect to the Fermi temperature.
Using Electromagnetic Force in Weft Insertion of a Loom (2005)

Weft insertion in weaving is an important subject, which has been studied by many research workers, for decades. A number of mechanisms have been invented, designed, manufactured, developed and employed for this purpose, although, only some of these systems have been commercialised. The present paper reports a magnetic weft inserting system, which was designed and manufactured as a model on basis of electromagnetic force. Different features of the system and the parameters affecting in weft insertion are explained and discussed, also.
Reflector antennas for high power, near field elliptical spot beams with circular polarisation (1993)

A set of three reflectors using elliptical surfaces to provide near field focusing, each having a cluster of circularly polarised feeds providing multi-band performance has been developed. Frequency bandwidth at any one band is typically 10%. The antenna configuration was dictated heavily by system needs for bandwidth, spot size and overall efficiency. Spot size and shape were set after a trade- off including achievable power density, spot vertical and horizontal dimensions, spot alignment under worst case environmental conditions, etc. In order to minimise cost, the design was taken directly from computer model to hardware. Reflectors were analysed using physical optics and GTD, feeds were designed using mode matching techniques with finite element analysis used for certain feed components.
Antibiotic-induced gut microbiota disruption during human endotoxemia: a randomised controlled study (2016)

ClinicalTrials.gov (NCT02127749; Pre-results).
In Vivo Aggregation of Clearable Bimetallic Nanoparticles with Interlocked Surface Motifs for Cancer Therapeutics Amplification (2023)

Although renal-clearable luminescent metal nanoparticles (NPs) have been widely developed, their application to efficient cancer therapy is still limited due to low reactive oxygen species (ROS) production. Here, a novel system of clearable mercaptosuccinic acid (MSA) coated Au-Ag bimetallic NPs is designed to enhance ROS production. The results show that the strong COO-Ag coordination bonds between the carboxylic acid groups of MSA and Ag atoms on the Au-Ag bimetallic NPs could construct high-rigidity interlocked surface motifs to restrict the intrananoparticle motions for enhanced ROS generation. Moreover, bimetallic NPs exhibit pH-responsive self-assembly capability under the acidic environment inside lysosomes of cancer cells at both <i>in vitro</i> and <i>in vivo</i>, restricting the internanoparticle motions to further boost ROS production. The well-designed bimetallic NPs show high tumor targeting efficiency, fast elimination from the body through rapid liver biotransformation, and extensive destruction to cancer cells, resulting in good security and prominent therapeutic performance.
Reconcillation and Rectification of Process Flow and Inventory Data (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReconcillation and Rectification of Process Flow and Inventory DataRichard S. Mah, Gregory M. Stanley, and Dennis M. DowningCite this: Ind. Eng. Chem. Process Des. Dev. 1976, 15, 1, 175–183Publication Date (Print):January 1, 1976Publication History Published online1 May 2002Published inissue 1 January 1976https://pubs.acs.org/doi/10.1021/i260057a030https://doi.org/10.1021/i260057a030research-articleACS PublicationsRequest reuse permissionsArticle Views306Altmetric-Citations185LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
A cell-free replication system for human polyomavirus JC DNA (1997)

The human polyomavirus JC virus (JCV) establishes persistent infections in most individuals and is the etiologic agent of progressive multifocal leukoencephalopathy. In this report, we describe the establishment of a soluble cell-free system that is capable of replicating exogenous plasmid DNA containing the JCV origin of replication. Replication in this system is completely dependent on the addition of JCV large T antigen (TAg). To prepare JCV TAg for replication analysis, a recombinant baculovirus containing the JCV TAg-coding sequence was generated. TAg expressed in insect cells was purified by metal chelate chromatography. JCV TAg supported initiation of JCV DNA replication in the presence of DNA polymerase alpha-primase, replication protein A, and topoisomerase I in a dose-dependent manner and was also capable of supporting DNA replication in crude human cell extracts. Point mutation of TAg-binding site I strongly diminished TAg binding and concomitantly reduced JCV DNA replication in vivo and in vitro by approximately 50%. Point mutation of TAg-binding site II or deletion of the early palindrome completely abolished replication of JCV origin-containing plasmid DNA in vivo and in vitro, marking these sequences as essential components of the JCV core origin. A comparison of several TAgs showed that simian virus 40 TAg, but not mouse polyomavirus (PyV) TAg, supported replication of a plasmid containing a JCV origin. These findings provide evidence that replication in the cell-free system faithfully mimics JCV DNA replication in vivo. Therefore, it may be a useful tool for future analysis of interactions between JCV and its host cell.
Effect of Low Pressure on Surface Charge of Electrets (1968)

Electrets prepared from Mylar and a polystyrene material were exposed to low pressure. The effective surface charge of the electrets decreased as the pressure was lowered. It is proposed that the charge decrease is due to either desorption of charge sources from the electret surfaces or spark breakdown on the electret surface.
Laboratory and Field Evaluations of Oviposition Responses of Aedes albopictus and Aedes triseriatus (Diptera: Culicidae) to Oak Leaf Infusions (1998)

Organic infusions created by fermenting white oak (Quercus alba L.) leaves in water were evaluated as sources of attractant odorants and contact oviposition stimulants for gravid Aedes albopictus (Skuse) and Aedes triseriatus (Say). Infusions were bioassayed in the laboratory by giving single females a choice of ovipositing in 1 container with infusion and 7 containers with water. Ae. albopictus laid significantly more eggs in containers with infusion, regardless of concentration (dilutions ranging from 10 to 100%) or age (fermentation periods of 7, 28, 60 d), than in containers holding water. The largest proportion of eggs (76.8%) was deposited in response to a 60% concentration of 7-d-old infusion. In contrast, Ae. triseriatus exhibited variable oviposition responses but generally deposited the largest number of eggs in only a few concentrations of older age infusions. In binary "sticky screen" bioassays, there was no difference between the numbers of females attracted to infusion or water, indicating that oviposition responses to infusion were mediated by contact chemostimulants rather than by attraction to odorants. Oviposition responses to infusions by field populations of Ae. albopictus and Ae. triseriatus in Raleigh, NC, were evaluated with pairs of oviposition traps, one containing infusion and the other containing water. Generally, Ae. albopictus laid significantly more eggs in ovitraps containing infusion regardless of its age (7, 28, and 60 d old) or the mass of leaves fermented (126 g = 1x or 504 g = 4x) than in water. In contrast, Ae. triseriatus deposited an equivalent number of eggs in traps containing water or 1x, 80% infusion regardless of its age; however, the oviposition response to ovitraps containing 4x, 7-d-old, 50% infusion was significant. Placement of an automobile tire behind an ovitrap did not increase the number of Ae. albopictus eggs laid in ovitraps containing 4x, 7-d-old, 50% infusion or water relative to ovitraps without a tire. Our research indicates that baiting ovitraps with oak leaf infusion would increase the sensitivity of surveillance efforts for Ae. albopictus and Ae. triseriatus.
The role of surface Zn2+ ions in the transesterification of vegetable oils over ZnO supported on Al2O3 and Fe2O3 (2013)

ZnO–Al<sub>2</sub>O<sub>3</sub> and ZnO–Fe<sub>2</sub>O<sub>3</sub> with different loadings of ZnO (5–20 wt%) along with ZnAl<sub>2</sub>O<sub>4</sub> and ZnFe<sub>2</sub>O<sub>4</sub> were prepared and tested in the transesterification of sunflower, waste cooking oil and Jatropha oil.
Design and Implementation of a Digital Controller for DC-to-DC Power Converters (2000)

&lt;div class="htmlview paragraph"&gt;A digital signal processor (DSP) solution is proposed to control an H-bridge DC-DC isolated output power converter. The multiple mode digital controller is evaluated with an existing Westinghouse 1-kW power stage. The digital controller was developed using the dSPACE [&lt;span class="xref"&gt;1&lt;/span&gt;] rapid prototype development system and MATLAB/Simulink. It is evaluated using a real-time digital control development platform that included the actual Westinghouse converter power stage. Preliminary digital controller performance is presented that warrants continued investigation and development of this application of digital control and supports the use of the DSP as a viable component in Power Management and Distribution (PMAD) applications.&lt;/div&gt;
2 D Self‐Assembly and Catalytic Homo‐coupling of the Terminal Alkyne 1,4‐Bis(3,5‐diethynyl‐phenyl)butadiyne‐1,3 on Ag(111) (2013)

Abstract The covalent linking of terminal alkynes is a promising approach for the bottom‐up fabrication of novel, carbon‐rich or all‐carbon materials, which was recently extended towards interfacial architectures. Here we report the synthesis of a novel organic species (1,4‐bis(3,5‐diethynylphenyl)butadiyne‐1,3) and employ it to engineer self‐assembled supramolecular layers and covalent networks on the Ag(111) surface. Samples are prepared in‐situ under ultra‐high vacuum conditions and examined at the molecular level with scanning tunneling microscopy. After evaporating the two‐fold symmetric molecule onto the substrate at temperatures below 300 K and subsequent cooling to 5 K we find highly regular supramolecular phases commensurate with the underlying silver surface and stabilized mainly by weak, non‐covalent interactions originating from the terminal ethynyl moieties. Annealing at temperatures between 350 and 500 K triggers catalytic conversions with the pertaining covalent coupling reactions resulting in small aggregates or irregular polymeric networks. Our detailed analysis of the binding motifs demonstrates that two competing reaction pathways dominate the covalent linking processes. The first is the Glaser–Hay‐type homo‐coupling of two alkyne terminations leading to a linear butadiyne bridge. The second is the connection of a butadiyne group to a laterally attacking terminal alkyne, converting the attacked ethyne to ethene moieties, which presents a major obstacle for the production of regular networks.
First Total Synthesis of Protoapigenone and Its Analogues as Potent Cytotoxic Agents (2007)

Protoapigenone (1), isolated from Thelypteris torresiana, previously showed significant cytotoxic activity against five human cancer cell lines. In a continued structure-activity relationship study, the first total synthesis and modification of 1 were achieved. All synthesized compounds and related intermediates were evaluated for cytotoxic activity against five human cancer cell lines, HepG2, Hep3B, MDA-MB-231, MCF-7, and A549. Among them, 24 showed 2.2-14.2-fold greater cytotoxicity than 1 and naphthyl A-ring analogues remarkably enhanced the activity.
Prepubertal retroareolar cysts (2021)

Bluish nodular mammary lesions in prepubertal girls are a challenging diagnosis. Retroareolar cysts are rare in this population, but relatively common among adolescent women. This diagnosis can be suspected clinically and ultimately confirmed by cutaneous ultrasonography, avoiding unnecessary biopsies or complex radiologic studies.
Modulation of myosin by cardiac myosin binding protein-C peptides improves cardiac contractility in ex-vivo experimental heart failure models (2022)

Cardiac myosin binding protein-C (cMyBP-C) is an important regulator of sarcomeric function. Reduced phosphorylation of cMyBP-C has been linked to compromised contractility in heart failure patients. Here, we used previously published cMyBP-C peptides 302A and 302S, surrogates of the regulatory phosphorylation site serine 302, as a tool to determine the effects of modulating the dephosphorylation state of cMyBP-C on cardiac contraction and relaxation in experimental heart failure (HF) models in vitro. Both peptides increased the contractility of papillary muscle fibers isolated from a mouse model expressing cMyBP-C phospho-ablation (cMyBP-C<sup>AAA</sup>) constitutively. Peptide 302A, in particular, could also improve the force redevelopment rate (k<sub>tr</sub>) in papillary muscle fibers from cMyBP-C<sup>AAA</sup> (nonphosphorylated alanines) mice. Consistent with the above findings, both peptides increased ATPase rates in myofibrils isolated from rats with myocardial infarction (MI), but not from sham rats. Furthermore, in the cMyBP-C<sup>AAA</sup> mouse model, both peptides improved ATPase hydrolysis rates. These changes were not observed in non-transgenic (NTG) mice or sham rats, indicating the specific effects of these peptides in regulating the dephosphorylation state of cMyBP-C under the pathological conditions of HF. Taken together, these studies demonstrate that modulation of cMyBP-C dephosphorylation state can be a therapeutic approach to improve myosin function, sarcomere contractility and relaxation after an adverse cardiac event. Therefore, targeting cMyBP-C could potentially improve overall cardiac performance as a complement to standard-care drugs in HF patients.