gebhart/patrepeval huggingface dataset:
Naloxone blocks the effects of delta 9-tetrahydrocannabinol on serum luteinizing hormone and prolactin in rats. (1983)

The present study was undertaken to determine if the effects of delta 9-tetrahydrocannabinol on gonadotropin secretion are mediated through endogenous opioid neurons in the rat. Ovariectomized rats were treated with estradiol-benzoate (EB, day O) and with progesterone (P) at 11:00 h on day 2. At 13:00 h (day 2), these estradiol primed and progesterone-treated (EBP) animals received either delta 9-THC (3mg/kg in oil, i.m.); naloxone (Nal) 3 mg/kg in saline, s.c.) or delta 9-THC + Nal. All animals were decapitated at 16:00 h and trunk sera were assayed for luteinizing hormone (LH) and prolactin (Prl), while medial basal hypothalami (MBH) were assayed for luteinizing hormone-releasing hormone (LHRH). Naloxone enhanced the EBP-induced hypersecretion of LH by 2-fold while delta 9-THC completely blocked the EBP-induced secretion of LH. delta 9-THC slightly diminished the stimulatory effect of Nal on LH secretion and caused a 2-fold increase in serum Prl concentrations, while Nal did not influence the serum PRL levels in these EBP rats. However, Nal did block the stimulatory effects of delta 9-THC on Prl secretion. delta 9-THC caused a significant increase in MBH content of LHRH, an effect which was prevented by Nal. These results suggest that the inhibitory effects of delta 9-THC on serum LH and the stimulatory effect of the cannabinoid on Prl are mediated by an opioid mechanism.
Roentgenological Appearance of Corti-Costeroid-Produced Peptic Ulcers (1958)

SummaryThe authors observed 15 peptic ulcers during corticosteroid therapy which were characterised by the following features: a predilection of the location near the pylorus,large and deep, and often penetrating, ulcer niches,mild clinical symptoms,good clinical and roentgenological healing; this concerns as well 7 cases in which corticosteroid administration was continued,lack of late complications, which are not unusual in connection with ulcers at or near the pylorus.
Swelling effect of semicrystalline poly(vinyl alcohol) in hydrogen peroxide (1991)

Abstract The effect of hydrogen peroxide on the physicochemical properties of semicrystalline poly(vinyl alcohol) (PVA) has been investigated. Significant and irreversible increases in equilibrium water swelling, dissolved oxygen permeability, and surface wettability have been observed in PVA samples treated with concentrated hydrogen peroxide. Based on the small amount of carbonyl content detected and the crystallinity reduction in hydrogen‐peroxide‐treated poly(vinyl alcohol) samples, a mechanism involving a combination of hydrogen‐peroxide‐induced oxidative chain scission and dissolution of crystalline regions in poly(vinyl alcohol) is proposed for the observed swelling kinetics and associated changes in polymer properties.
Transcriptomes of germinal zones of human and mouse fetal neocortex suggest a role of extracellular matrix in progenitor self-renewal (2012)

The expansion of the neocortex during mammalian brain evolution results primarily from an increase in neural progenitor cell divisions in its two principal germinal zones during development, the ventricular zone (VZ) and the subventricular zone (SVZ). Using mRNA sequencing, we analyzed the transcriptomes of fetal human and embryonic mouse VZ, SVZ, and cortical plate. In mouse, the transcriptome of the SVZ was more similar to that of the cortical plate than that of the VZ, whereas in human the opposite was the case, with the inner and outer SVZ being highly related to each other despite their cytoarchitectonic differences. We describe sets of genes that are up- or down-regulated in each germinal zone. These data suggest that cell adhesion and cell-extracellular matrix interactions promote the proliferation and self-renewal of neural progenitors in the developing human neocortex. Notably, relevant extracellular matrix-associated genes include distinct sets of collagens, laminins, proteoglycans, and integrins, along with specific sets of growth factors and morphogens. Our data establish a basis for identifying novel cell-type markers and open up avenues to unravel the molecular basis of neocortex expansion during evolution.
The Impact of Fischer–Tropsch Diesel on the Oxidation Stability of Biodiesel (FAME) Blends (2009)

Abstract Fischer–Tropsch (FT) distillates and first generation biodiesel are alternative fuels that can both be used directly as neat fuels in an internal combustion diesel engine or as blend stocks with conventional diesel fuel. Biodiesel is generally produced by the catalytic trans-esterification of triglycerides (vegetable oil) with methanol to form fatty acid methyl esters (FAME) and glycerol as a by-product. The FT process (or FT synthesis) is a catalyzed chemical reaction in which synthesis gas (syngas), a mixture of carbon monoxide and hydrogen, is converted into liquid hydrocarbons of various compositions. The oxidation and thermal stability of diesel fuel are very important properties since unstable diesel fuels can form soluble gums and or insoluble organic particulates that can clog the fuel filters and fuels system components. In the quest for increased efficiency of internal combustion compression ignition engines, the engines are increasingly downsized and turbo charged. These developments, together with the latest demands from modern injector systems, place a greater demand on the oxidative and thermal stability performance of a fuel due to the exposure of fuels to higher temperatures in comparison to historic engine and injector designs. Recirculation of heated fuel can also cause injector deposits originating from either gum or particulate formation. Biodiesel (FAME) and FT diesel have shown to be fully compatible as blend components with conventional crude derived diesel. FT diesel, produced from the low temperature FT (LTFT) process, generally has a lower density and viscosity and good cold flow properties. It is also a very stable fuel, which compensates for the high viscosity and density, poor cold flow properties, and unstable nature associated with biodiesel (FAME). This paper discusses the results obtained from a comparative study of the oxidation stability (using the Rancimat methodology) of FT (high temperature FT and LTFT) and petroleum diesel fuels, blended with up to 20 vol % of soya and rapeseed derived biodiesel (FAME).
Effects of Surface Treatments on Mechanical properties of Knitted Structural Composites (1992)

Effects of surface treatments on tensile property of knitted structural composites were discussed. The maximum tensile load of weft knitted fabrics of silicone-coating aramid yams was higher than that of none coated yarns. Moreover, the maximum tensile load of knitted fabrics increased by means of the O 2 plasma 2 min. exposure. In 20 min. exposure both maximum tensile load of knitted fabrics and tensile strength of knitted structural composites were lower than those in none and 2 min. exposure. In the O 2 plasma 2 min. and 20 min. treated knitted fabric of silicone-coating yarns, it can be seen that the adhesion between the reinforcement and the matrix of the knitted structural composite was weakened. However, this has not affected tensile strength of knitted structural composites.
Photophysics of a cofacial porphyrin-quinone cage molecule and related compounds: fluorescence properties, flash transients, and electron-transfer reactions (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotophysics of a cofacial porphyrin-quinone cage molecule and related compounds: fluorescence properties, flash transients, and electron-transfer reactionsJonathan S. Lindsey, John K. Delaney, David C. Mauzerall, and Henry. LinschitzCite this: J. Am. Chem. Soc. 1988, 110, 11, 3610–3621Publication Date (Print):May 1, 1988Publication History Published online1 May 2002Published inissue 1 May 1988https://pubs.acs.org/doi/10.1021/ja00219a041https://doi.org/10.1021/ja00219a041research-articleACS PublicationsRequest reuse permissionsArticle Views642Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Efficacy of karanjin and different extracts of Pongamia pinnata against selected insect pests. (2006)

Methanolic extracts of crude seed oil of Pongamia pinnata (Karanj) showed the maximum growth reduction and antifeedancy against the larvae of S. litura (EC50: 0.11 and 0.21% respectively) and was also most toxic to Trogoderma granarium (EC50: 35.1 μg/insect) whereas karanj leaves (EC50: 19.9 μg/insect) exhibited the toxicity against Tribolium castaneum. Crude seed oil of karanj showed the maximum repellency (EC50: 0.2 mg/cm2) against T. granarium.
0.16-0.25 pJ/bit, 8 Gb/s Near-Threshold Serial Link Receiver With Super-Harmonic Injection-Locking (2012)

A near-threshold forwarded-clock I/O receiver architecture is presented. In the proposed receiver, the majority of the circuitry is designed to operate in the near-threshold region at 0.6 V supply to save power, with the exception of only the global clock buffer, test buffers and synthesized digital circuits at the nominal 1 V supply. To ensure the quantizers are working properly with this low supply, a 1:10 direct demultiplexing rate is chosen as a demonstration of achieving low supply operation by high-parallelism. A novel low-power super-harmonic injection-locked ring oscillator is proposed to generate deskewable symmetric multi-phase local clock phases. The relative performance impact of including a per-data lane sample-and-hold (S/H) to improve quantizer aperture time at low voltage is demonstrated with two receiver prototypes fabricated in a 65 nm CMOS technology. Including the amortized power of global clock distribution, the receiver without S/H consumes 1.3 mW and the one with S/H consumes 2 mW at an 8 Gb/s input data rate, which converts to 0.163 pJ/bit and 0.25 pJ/bit, respectively. Measurement results show both receivers get BER <; 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-12</sup> across a 20-cm FR4 PCB channel.
Conventional B cells, not B-1 cells, are responsible for producing autoantibodies in lpr mice. (1993)

Mice homozygous for the lpr gene develop autoantibodies and polyclonal B cell activation similar to what is seen in human systemic lupus erythematosus patients. We have previously shown that an lpr-specific intrinsic B cell defect was necessary for autoantibody production in this model. In the current study, we have further defined these autoantibody-producing B cells. Two major subsets of B cells have been described. B-1 cells (CD5+ B cells) can be distinguished from conventional B cells on the basis of phenotype, cytokine secretion, gene expression, anatomical location, and function. In addition, B-1 cells have been implicated in autoimmunity in several murine and human studies. To address the question of which B cell subset produces autoantibodies in lpr mice, we used immunoglobulin heavy chain (Igh) allotype-marked peritoneal (B-1 cell source) and bone marrow (conventional B cell source) cells from lpr mice to establish B cell chimeras. We used two general approaches. In one, we reconstituted sublethally irradiated mice with B-1 cells of one allotype and bone marrow cells of another allotype. In the second method, we suppressed endogenous B cells in neonatal mice with allotype-specific anti-IgM antibody, and injected peritoneal cells of another allotype. After antibody treatment was stopped, the mouse's conventional B cells recovered, but the B-1 subset was only reconstituted by the donor. In both types of chimeras, antichromatin, rheumatoid factor, and anti-single stranded DNA (ssDNA) autoantibodies were produced by the conventional B cell bone marrow source. In addition, an age-related decrease in peritoneal B-1 cells was seen, even in unmanipulated lpr mice. These data show that lpr B-1 cells are not important producers of autoantibodies. Conventional B cells are the source of autoantibodies directed at chromatin, ssDNA, and IgG.
CNS Efficacy of Osimertinib in Patients With T790M-Positive Advanced Non–Small-Cell Lung Cancer: Data From a Randomized Phase III Trial (AURA3) (2018)

Purpose In patients with epidermal growth factor receptor ( EGFR) mutation-positive advanced non-small-cell lung cancer (NSCLC), there is an unmet need for EGFR-tyrosine kinase inhibitors with improved CNS penetration and activity against CNS metastases, either at initial diagnosis or time of progression. We report the first comparative evidence of osimertinib CNS efficacy versus platinum-pemetrexed from a phase III study (AURA3; ClinicalTrials.gov identifier: NCT02151981) in patients with EGFR T790M-positive advanced NSCLC who experience disease progression with prior EGFR-tyrosine kinase inhibitor treatment. Methods Patients with asymptomatic, stable CNS metastases were eligible for enrollment and were randomly assigned 2:1 to osimertinib 80 mg once daily or platinum-pemetrexed. A preplanned subgroup analysis was conducted in patients with measurable and/or nonmeasurable CNS lesions on baseline brain scan by blinded independent central neuroradiological review. The CNS evaluable for response set included only patients with one or more measurable CNS lesions. The primary objective for this analysis was CNS objective response rate (ORR). Results Of 419 patients randomly assigned to treatment, 116 had measurable and/or nonmeasurable CNS lesions, including 46 patients with measurable CNS lesions. At data cutoff (April 15, 2016), CNS ORR in patients with one or more measurable CNS lesions was 70% (21 of 30; 95% CI, 51% to 85%) with osimertinib and 31% (5 of 16; 95% CI, 11% to 59%) with platinum-pemetrexed (odds ratio, 5.13; 95% CI, 1.44 to 20.64; P = .015); the ORR was 40% (30 of 75; 95% CI, 29% to 52%) and 17% (7 of 41; 95% CI, 7% to 32%), respectively, in patients with measurable and/or nonmeasurable CNS lesions (odds ratio, 3.24; 95% CI, 1.33 to 8.81; P = .014). Median CNS duration of response in patients with measurable and/or nonmeasurable CNS lesions was 8.9 months (95% CI, 4.3 months to not calculable) for osimertinib and 5.7 months (95% CI, 4.4 to 5.7 months) for platinum-pemetrexed; median CNS progression-free survival was 11.7 months and 5.6 months, respectively (hazard ratio, 0.32; 95% CI, 0.15 to 0.69; P = .004). Conclusion Osimertinib demonstrated superior CNS efficacy versus platinum-pemetrexed in T790M-positive advanced NSCLC.
Morphological and Thermal-Mechanical Stretching Properties on Polymeric Lateral Flow Nitrocellulose Membrane (2009)

Lateral flow nitrocellulose (NC) membrane is well-known as the transport medium in a diagnostic test strip. The function of the membrane is greatly influenced by its physical morphology and chemical composition. Hence, a thermal-mechanical stretching technique was introduced to modify polymeric membrane morphologies for various performance studies. Membrane samples were stretched at the appropriate settings of stretching elongation, stretching speed, and stretching temperature. Experimental, AFM, and SEM results show that membrane morphologies changed significantly as a result of the stretching effects. The current study has demonstrated that physical thermal-mechanical stretching properties are important in modifying membrane morphologies for specific applications, since these parameters potentially affect the membrane’s final performances. These findings provided some insight on the relationship between stretched membranes’ morphology and performances. This knowledge is useful in producing both versatile and durable nitrocellulose membranes for lateral flow applications.
Particle orbits and drift surfaces in a heliac (1998)

Drift orbit topologies in the H-1NF heliac are described using guiding centre calculations and by the approximate second adiabatic invariant. Results are presented that are representative of the orbit topologies across the magnetic configuration space of the machine and in the presence of radial electric fields. The trapped particle population can be divided into a number of different subclasses using a scheme based on the number of maxima in parallel kinetic energy between bounce points.
Otimização na programação de horários de professores/turmas: Modelo Matemático, Abordagem Heurística e Método Misto (2010)

At the beginning of a school year, in any educational institution, there is always a concerning about the distribution of the classesâ days and schedules for each one of their teachers. Besides all computational advances, the majority of schools still make the construction of the scholar scheduling table in a manual way, making this task too slow and inefficient. The goal of this paper is to present three techniques (exact, heuristic and mixed) which can find a solution that meets the pedagogical and operational constraints of the institutions, as well as the preferences of each teacher in relation to the classesâ days and schedules. In order to compare the techniques performances, it was developed a prototype for a scholar schedule of a municipal school located in Araucária, PR city. All the three methods utilized in this paper presented better results to the study case analyzed.
Radiation source considerations relevant to next-generation x-ray diffraction imaging for security screening applications (2009)

X-ray diffraction imaging (XDi) refers to the volumetric analysis of extended, inhomogenous objects by spatially-resolved x-ray diffraction. Following a brief description of some of the areas in which x-ray diffraction (XRD) is currently impacting on the detection of materials of interest in the security environment, the principles of energy-dispersive x-ray diffraction tomographic systems of the 1<sup>st</sup>, 2<sup>nd</sup> and 3<sup>rd</sup> generation are described. The Multiple Inverse Fan Beam (MIFB) topology for 3rd Generation XDi, in which the XRD properties of a 2-D spatial array of volume elements are investigated in parallel without mechanical scanning, is described. 3rd Generation XDi is being driven among other things by technological developments taking place in the field of Multi-Focus X-ray Sources (MFXS) from which representative results are presented. MFXS source requirements for Next-Generation MIFB XDi are summarized and the potential of 3rd Generation XDi for rapid, accurate and affordable screening in the Checkpoint and Hold Baggage environments is summarized.
Reduced bone mineral density among HIV-infected, virologically controlled young men (2018)

There is a high prevalence of reduced BMD among young men, despite persistent virological control of HIV-infection. This observation raises the question of extending current recommendations for BMD assessment to PLHIV aged < 50 years for whom BMD has stabilized after cART initiation, i.e. treated for more than three years.
Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation (2012)

Ezh2 (Enhancer of zeste homolog 2) protein is the enzymatic component of the Polycomb repressive complex 2 (PRC2), which represses gene expression by methylating lysine 27 of histone H3 (H3K27) and regulates cell proliferation and differentiation during embryonic development. Recently, hot-spot mutations of Ezh2 were identified in diffused large B-cell lymphomas and follicular lymphomas. To investigate if tumor growth is dependent on the enzymatic activity of Ezh2, we developed a potent and selective small molecule inhibitor, EI1, which inhibits the enzymatic activity of Ezh2 through direct binding to the enzyme and competing with the methyl group donor S-Adenosyl methionine. EI1-treated cells exhibit genome-wide loss of H3K27 methylation and activation of PRC2 target genes. Furthermore, inhibition of Ezh2 by EI1 in diffused large B-cell lymphomas cells carrying the Y641 mutations results in decreased proliferation, cell cycle arrest, and apoptosis. These results provide strong validation of Ezh2 as a potential therapeutic target for the treatment of cancer.
The genus Arthrodamaeus Grandjean (Acariformes, Oribatida, Gymnodamaeidae) (1997)

Une revision du genre Arthrodamaeus Grandjean, 1954 est faite, en meme temps qu'une discussion sur l'identite veritable de l'espece type, A. reticulatus (Berlese, 1910) est presentee. Cinq especes nouvelles, originaires de la region mediterraneenne occidentale, sont decrites : A. mediterraneus sp. nov., A. rosarius sp. nov., A. bicristatus sp. nov., A. octosetosus sp. nov. et A. cereus sp. nov. A. reticulatus, l'espece type, est redecrite. Une cle pour identifier les sept especes du genre a ete etablie. On termine par quelques considerations sur la distribution (surtout mediterraneenne) du genre et son adaptation aux conditions de temperatures et de secheresse.
An Intrabody Based on a Llama Single-domain Antibody Targeting the N-terminal α-Helical Multimerization Domain of HIV-1 Rev Prevents Viral Production (2010)

The human immunodeficiency virus, type 1 (HIV-1)-encoded Rev protein is essential for the expression of late viral mRNAs. Rev forms a large organized multimeric protein-protein complex on the Rev response element of these viral mRNA species and transports them from the nucleus to the cytoplasm, exploiting the CRM1-mediated cellular machinery. Here we report the selection of a nanobody, derived from a llama heavy-chain only antibody, that efficiently blocks the assembly of Rev multimers. The nanobody inhibits HIV-1 replication in cells and specifically suppresses the Rev-dependent expression of partially spliced and unspliced HIV-1 RNA. In HIV-susceptible cells, this nanobody thus has potential as an effective anti-HIV agent using genetic immunization strategies. Its binding site was mapped to Rev residues Lys-20 and Tyr-23 located in the N-terminal alpha-helical multimerization domain. In the presence of this nanobody, we observed an accumulation of dimeric Rev species, supporting a head-to-head/tail-to-tail molecular model for Rev assembly. The results indicate that the oligomeric assembly of Rev follows an ordered stepwise process and identify a new epitope within Rev that could guide strategies for the development of novel HIV inhibitors.