PD60-02 CAN THE TIME INTERVAL BETWEEN MRI AND FUSION BIOPSY AFFECT THE CANCER DETECTION RATES? (2019)

You have accessJournal of UrologyProstate Cancer: Detection & Screening VII (PD60)1 Apr 2019PD60-02 CAN THE TIME INTERVAL BETWEEN MRI AND FUSION BIOPSY AFFECT THE CANCER DETECTION RATES? Maria Becerra*, Feng Miao, Isildinha Reis, Daniel Furlong, Taylor Johnson, Nachiketh Soodana-Prakash, Dipen Parekh, Chad Ritch, Bruno Nahar, Mark Gonzalgo, and Sanoj Punnen Maria Becerra*Maria Becerra* More articles by this author , Feng MiaoFeng Miao More articles by this author , Isildinha ReisIsildinha Reis More articles by this author , Daniel FurlongDaniel Furlong More articles by this author , Taylor JohnsonTaylor Johnson More articles by this author , Nachiketh Soodana-PrakashNachiketh Soodana-Prakash More articles by this author , Dipen ParekhDipen Parekh More articles by this author , Chad RitchChad Ritch More articles by this author , Bruno NaharBruno Nahar More articles by this author , Mark GonzalgoMark Gonzalgo More articles by this author , and Sanoj PunnenSanoj Punnen More articles by this author View All Author Informationhttps://doi.org/10.1097/01.JU.0000557226.53128.aeAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVES: Multiparametric MRI fusion guided biopsy (FBx) has been shown to reliably improve the prostate cancer (PCa) detection. We aim to evaluate if the detection of prostate cancer on targeted biopsy varied based on the time interval between the MRI and the FBx. METHODS: A prospectively maintained database of patient undergoing MRI followed by FBx for elevated PSA between 10/2014 and 07/2018 at our institution was reviewed. Patients with previously diagnosed PCa were excluded from the analysis. Time between MRI and FBx were evaluated as a continuous variable and as categorical variable as follows ≤5, 5-10, >10 weeks (w). Data were documented on a per lesion basis and each target in the MRI was classified for the level of suspicion of malignancy based on the Prostate Imaging-Reporting and Data System (PI-RADS). Generalized estimating equation models for correlated binary outcome data was fitted to assess the effect of time (or time intervals) between MRI and FBx on the histopathological findings in the defined MRI targets. Separated models were fitted for the detection of any cancer or Gleason 7 or higher PCa (Gleason 7 or greater) with adjustment for relevant characteristics. RESULTS: A total 1,181 lesions from 806 men were analyzed. Prostate cancer was detected in 34.5% (407) of lesions, with 21.4% (253), 13% (154) and 65.5% (774) of lesions detecting clinically significant cancer (CSC), indolent (Gleason 6) PCa, or benign pathology, respectively. The MRI was performed <5w apart from the FBx in 423 patients, within 5-10 w in 261 and >10w in 122 patients. Adjusting for level of suspicion, previous biopsy result, age at MRI, race/ethnicity and marital status, the detection rates of any or CSC were not statistically different in any of the time intervals between the MRI/FBx (p=0.931 and p=0.538, respectively). Furthermore, when analyzing time as a continuous variable (per week increase) there was no association between time from MRI to FBx and PCa detection (p=0.849 and p=0.666, respectively).RESULTS: A total 1,181 lesions from 806 men were analyzed. Prostate cancer was detected in 34.5% (407) of lesions, with 21.4% (253), 13% (154) and 65.5% (774) of lesions detecting clinically significant cancer (CSC), indolent (Gleason 6) PCa, or benign pathology, respectively. The MRI was performed <5w apart from the FBx in 423 patients, within 5-10 w in 261 and >10w in 122 patients. Adjusting for level of suspicion, previous biopsy result, age at MRI, race/ethnicity and marital status, the detection rates of any or CSC were not statistically different in any of the time intervals between the MRI/FBx (p=0.931 and p=0.538, respectively). Furthermore, when analyzing time as a continuous variable (per week increase) there was no association between time from MRI to FBx and PCa detection (p=0.849 and p=0.666, respectively). CONCLUSIONS: Our data suggests that the time from MRI to fusion biopsy was not a predictor of prostate cancer detection on targeted biopsy. While these findings require further validation in cohorts with longer time intervals between MRI and fusion biopsy, it provides important information for patients and providers about the timing of biopsy after MRI. Source of Funding: None Miami, FL; Miami, FL; Miami, FL© 2019 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 201Issue Supplement 4April 2019Page: e1096-e1097 Advertisement Copyright & Permissions© 2019 by American Urological Association Education and Research, Inc.MetricsAuthor Information Maria Becerra* More articles by this author Feng Miao More articles by this author Isildinha Reis More articles by this author Daniel Furlong More articles by this author Taylor Johnson More articles by this author Nachiketh Soodana-Prakash More articles by this author Dipen Parekh More articles by this author Chad Ritch More articles by this author Bruno Nahar More articles by this author Mark Gonzalgo More articles by this author Sanoj Punnen More articles by this author Expand All Advertisement PDF downloadLoading ...