gebhart/patrepeval huggingface dataset:
The role of big data in improving power system operation and protection (2013)

This paper focuses on the use of extremely large data sets in power system operation, control, and protection, which are difficult to process with traditional database tools and often termed big data. We will discuss three aspects of using such data sets: feature extraction, systematic integration for power system applications, and examples of typical applications in the utility industry. The following analytics tasks based on big data methodology are elaborated upon: corrective, predictive, distributed and adaptive. The paper also outlines several research topics related to asset management, operation planning, realtime monitoring and fault detection/protection that present new opportunities but require further investigation.
Antibacterial activity of commercially available plant-derived essential oils against oral pathogenic bacteria (2015)

This work investigated the antibacterial activity of 15 commercially available plant-derived essential oils (EOs) against a panel of oral pathogens. The broth microdilution method afforded the minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) of the assayed EOs. The EO obtained from Cinnamomum zeylanicum (Lauraceae) (CZ-EO) displayed moderate activity against Fusobacterium nucleatum (MIC and MBC = 125 μg/mL), Actinomyces naeslundii (MIC and MBC = 125 μg/mL), Prevotella nigrescens (MIC and MBC = 125 μg/mL) and Streptococcus mutans (MIC = 200 μg/mL; MBC = 400 μg/mL). (Z)-isosafrole (85.3%) was the main chemical component of this oil. We did not detect cinnamaldehyde, previously described as the major constituent of CZ-EO, in specimens collected in other countries.
Experimental and Numerical Study of the Slow-Drift Motion of a Rectangular Barge Moored at an Inclined Beach (2010)

An experimental campaign is reported on the slow-drift motion of a rectangular barge moored in irregular beam seas. The 24 m long false bottom of the basin is raised and inclined at a slope of 5%, from 1.05 m below the free surface to 0.15 m above. The barge is moored successively at 4 different locations, in water-depths ranging from 54 to 21 cm. The measured slow-drift component of the sway motion is compared with state-of-the-art calculations based on Newman approximation. At 54 cm depth good agreement is obtained between calculations and measurements. At 21 cm depth the Newman calculation exceeds the measured value. When the flat bottom setdown contribution is added up, the calculated value is 2 to 3 times larger than the measured one. A second-order model is proposed to account for the shoaling of a bichromatic sea-state propagating in decreasing water-depth. Application of this numerical model to the scale-model tests shows that in shoaling conditions the setdown contribution to the slow-drift excitation can counteract and not necessarily add up to the Newman component.
Battery Lifetime Extension in a Stand-Alone Microgrid With Flexible Power Point Tracking of Photovoltaic System (2022)

In stand-alone dc microgrids (dcMGs), battery energy storage systems (BESSs) are conventionally used for regulating the dc-link voltage, causing a continuous battery operation. Though operating the photovoltaic (PV) system at its maximum power point (MPP) yields minimum battery discharge current, the opposite is true for battery charging current. Therefore, reducing the battery charging current based on its state-of-charge (SoC) and the amount of available PV surplus power (which can be treated as virtually stored energy) is an opportunity for improving the battery life. The main objective of the control strategy proposed in this article is to prolong the battery lifetime by reducing the charging current and keeping the battery SoC at lower values if the PV power is enough to supply the loads. Additionally, the PV system is used as the primary asset to regulate the microgrid voltage. The dynamic performance of the proposed control strategy is validated with experimental tests under various operating conditions. Furthermore, its effectiveness in prolonging the battery lifetime is evaluated using an aging model of a lithium-ion (Li-ion) battery (without loss of generality) by simulated case studies.
Clinical Management of Tuberculosis in the Context of HIV Infection (2004)

Globally, the HIV and tuberculosis epidemics are stoking each other, creating a public health crisis of enormous proportions. At the level of individuals, contemporaneous infection with M. tuberculosis and HIV poses great challenges to clinical management. This chapter provides an overview of active and latent tuberculosis treatment in HIV-infected and -uninfected individuals. The discussion focuses on medication issues, including interactions between antitubercular drugs, antiretroviral drugs, and medicines used for opportunistic infections and treatment in the face of comorbidities. Clinical questions specific to coinfection are discussed, including duration and timing initiation of therapy and immune reconstitution. Most of the data presented were generated in industrialized settings and are presented to assist patient management in such settings. However, given the disproportionate amount of TB/HIV in less-developed nations and the increasing availability of antiretroviral therapy in resource-limited settings, the issues presented will become increasingly relevant globally.
Diet associated with regular physical activity or drugs. A longitudinal study on obesity management. (2003)

The data confirm that in obese premenopausal women a regular physical activity improves the body composition, preventing the reduction of fat free mass hypocaloric diet-induced.
Cell Therapy of Congenital Corneal Diseases with Umbilical Mesenchymal Stem Cells: Lumican Null Mice (2010)

Umbilical mesenchymal stem cell transplantation is a promising treatment for congenital corneal diseases involving keratocyte dysfunction. Unlike donated corneas, umbilical mesenchymal stem cells are easily isolated, expanded, stored, and can be quickly recovered from liquid nitrogen when a patient is in urgent need.
High resolution solid state 19F n.m.r. spectroscopy as a tool for the study of ionic fluorides (1986)

J. H. Clark, E. M. Goodman, D. K. Smith, S. J. Brown and J. M. Miller, J. Chem. Soc., Chem. Commun., 1986, 657 DOI: 10.1039/C39860000657
Light Remodels Lipid Biosynthesis in Nannochloropsis gaditana by Modulating Carbon Partitioning between Organelles (2016)

The seawater microalga Nannochloropsis gaditana is capable of accumulating a large fraction of reduced carbon as lipids. To clarify the molecular bases of this metabolic feature, we investigated light-driven lipid biosynthesis in Nannochloropsis gaditana cultures combining the analysis of photosynthetic functionality with transcriptomic, lipidomic and metabolomic approaches. Light-dependent alterations are observed in amino acid, isoprenoid, nucleic acid, and vitamin biosynthesis, suggesting a deep remodeling in the microalgal metabolism triggered by photoadaptation. In particular, high light intensity is shown to affect lipid biosynthesis, inducing the accumulation of diacylglyceryl-N,N,N-trimethylhomo-Ser and triacylglycerols, together with the up-regulation of genes involved in their biosynthesis. Chloroplast polar lipids are instead decreased. This situation correlates with the induction of genes coding for a putative cytosolic fatty acid synthase of type 1 (FAS1) and polyketide synthase (PKS) and the down-regulation of the chloroplast fatty acid synthase of type 2 (FAS2). Lipid accumulation is accompanied by the regulation of triose phosphate/inorganic phosphate transport across the chloroplast membranes, tuning the carbon metabolic allocation between cell compartments, favoring the cytoplasm, mitochondrion, and endoplasmic reticulum at the expense of the chloroplast. These results highlight the high flexibility of lipid biosynthesis in N. gaditana and lay the foundations for a hypothetical mechanism of regulation of primary carbon partitioning by controlling metabolite allocation at the subcellular level.
Supplementary Data from Identification of the Transcription Factor Single-Minded Homologue 2 as a Potential Biomarker and Immunotherapy Target in Prostate Cancer (2023)

Supplementary Data from Identification of the Transcription Factor Single-Minded Homologue 2 as a Potential Biomarker and Immunotherapy Target in Prostate Cancer
Riccardin C: A natural product that functions as a liver X receptor (LXR)α agonist and an LXRβ antagonist (2005)

Liver X receptors (LXRs) alpha and beta share considerable sequence homology and several functions, respond to the same endogenous and synthetic ligands, and play critical roles in maintaining lipid homeostasis. In this study, liverwort-derived riccardin C (RC) and F (RF) were identified as an LXRalpha agonist/LXRbeta antagonist and an LXRalpha antagonist, respectively. RC and RF bound to LXRs, but had different abilities to recruit a coactivator and thereby induce transactivation. Despite its unique subtype-selective activity, RC enhanced ABCA1 and ABCG1 expression and cellular cholesterol efflux in THP-1 cells. RC may provide a novel tool for identifying subtype-function and drug development.
Role of robot-assisted radical prostatectomy in the management of high-risk prostate cancer (2014)

We aimed to evaluate the role of robot-assisted radical prostatectomy (RARP) in the management of high-risk prostate cancer (PCa), with a focus on oncological, functional and perioperative outcomes. Further, we also aimed to briefly describe our novel modification to conventional RARP that allows immediate organ retrieval and examination for intra-operative surgical margin assessment. A literature search of PubMed was performed for articles on the management of high-risk PCa. Papers written in English and concerning clinical outcomes following RARP for locally advanced and high-risk PCa were selected. Outcomes data from our own center were also included. A total of 10 contemporary series were evaluated. Biopsy Gleason score ≥ 8 was the most common cause for classification of patients into the high-risk PCa group. Biochemical failure rate, in the few series that looked at long-term follow-up, varied from 9% to 26% at 1 year. The positive surgical margin rate varied from 12% to 53.3%. Urinary continence rates varied from 78% to 92% at 1 year. The overall complication rates varied from 2.4% to 30%, with anastomotic leak and lymphocele being the most common complications. Long-term data on oncological control following RARP in high-risk patients is lacking. Short-term oncological outcomes and functional outcomes are equivalent to open radical prostatectomy (RP). Safety outcomes are better in patients undergoing RARP when compared with open RP. Improved tools for predicting the presence of organ-confined disease (OCD) are available. High-risk patients with OCD would be ideal candidates for RARP and would benefit most from surgery alone.
Growth and filament production of Pityrosporum orbiculare and P. ovale on human stratum corneum in vitro (1983)

When Pityrosporum orbiculare and P. ovale were incubated with stratum corneum epithelial cells, suspended in phosphate-buffered saline for 90 min at 37 degrees C, short filaments were produced in 11-17.5% of the yeast cells. A successful culture of P. orbiculare and P. ovale on human stratum corneum in vitro is described. When the stratum corneum pieces were incubated for 5 days in an environment with 7% CO2, a picture resembling that seen microscopically in tinea versicolor was observed. Filaments were produced in 39-48% of P. orbiculare and P. ovale cells; the longest pseudohyphae, 40-60 microns, were produced by P. ovale. This culture method provides the possibility of studying the parasitic mycelium form of P. orbiculare and P. ovale in vitro. The influence of antimycotics, other drugs, and interaction with other microorganisms can be studied.
Norepinephrine-deficient mice lack responses to antidepressant drugs, including selective serotonin reuptake inhibitors (2004)

Mice unable to synthesize norepinephrine (NE) and epinephrine due to targeted disruption of the dopamine beta-hydroxylase gene, Dbh, were used to critically test roles for NE in mediating acute behavioral changes elicited by different classes of antidepressants. To this end, we used the tail suspension test, one of the most widely used paradigms for assessing antidepressant activity and depression-related behaviors in normal and genetically modified mice. Dbh(-/-) mice failed to respond to the behavioral effects of various antidepressants, including the NE reuptake inhibitors desipramine and reboxetine, the monoamine oxidase inhibitor pargyline, and the atypical antidepressant bupropion, even though they did not differ in baseline immobility from Dbh(+/-) mice, which have normal levels of NE. Surprisingly, the effects of the selective serotonin reuptake inhibitors (SSRIs) fluoxetine, sertraline, and paroxetine were also absent or severely attenuated in the Dbh(-/-) mice. In contrast, citalopram (the most selective SSRI) was equally effective at reducing immobility in mice with and without NE. Restoration of NE by using L-threo-3,4-dihydroxyphenylserine reinstated the behavioral effects of both desipramine and paroxetine in Dbh(-/-) mice, thus demonstrating that the reduced sensitivity to antidepressants is related to NE function, as opposed to developmental abnormalities resulting from chronic NE deficiency. Microdialysis studies demonstrated that the ability of fluoxetine to increase hippocampal serotonin was blocked in Dbh(-/-) mice, whereas citalopram's effect was only partially attenuated. These data show that NE plays an important role in mediating acute behavioral and neurochemical actions of many antidepressants, including most SSRIs.
The Spatial Distribution of Sucrose Synthase Isozymes in Barley (1997)

The sucrose (Suc) synthase enzyme purified from barley (Hordeum vulgare L.) roots is a homotetramer that is composed of 90-kD type 1 Suc synthase (SS1) subunits. Km values for Suc and UDP were 30 mM and 5 [mu]M, respectively. This enzyme can also utilize ADP at 25% of the UDP rate. Anti-SS1 polyclonal antibodies, which recognized both SS1 and type 2 Suc synthase (SS2) (88-kD) subunits, and antibodies raised against a synthetic peptide, LANGSTDNNFV, which were specific for SS2, were used to study the spatial distribution of these subunits by immunoblot analysis and immunolocalization. Both SS1 and SS2 were abundantly expressed in endosperm, where they polymerize to form the five possible homo- and heterotetramers. Only SS1 homotetramers were detected in young leaves, where they appeared exclusively in phloem cells, and in roots, where expression was associated with cap cells and the vascular bundle. In the seed both SS1 and SS2 were present in endosperm, but only SS1 was apparent in the chalazal region, the nucellar projection, and the vascular bundle. The physiological implications for the difference in expression patterns observed are discussed with respect to the maize (Zea mays L.) model.
Advances in electromagnetic brain imaging (2010)

Non-invasive and dynamic imaging of brain activity in the sub-millisecond time-scale is enabled by measurements on or near the scalp surface using an array of sensors that measure magnetic fields (magnetoencephalography (MEG)) or electric potentials (electroencephalography (EEG)). Algorithmic reconstruction of brain activity from MEG and EEG data is referred to as electromagnetic brain imaging (EBI). Reconstructing the actual brain response to external events and distinguishing unrelated brain activity has been a challenge for many existing algorithms in this field. Furthermore, even under conditions where there is very little interference, accurately determining the spatial locations and timing of brain sources from MEG and EEG data is challenging problem because it involves solving for unknown brain activity across thousands of voxels from just a few sensors (~300). In recent years, my research group has developed a suite of novel and powerful algorithms for EBI that we have shown to be considerably superior to existing benchmark algorithms. Specifically, these algorithms can solve for many brain sources, including sources located far from the sensors, in the presence of large interference from unrelated brain sources. Our algorithms efficiently model interference contributions to sensors, accurately estimate sparse brain source activity using fast and robust probabilistic inference techniques. Here, we review some of these algorithms and illustrate their performance in simulations and real MEG/EEG data.
Low-Voltage-Driven Fabrication of a High-Luminance Multi-Layered Green OLED (2021)

This work presents a five-layered Organic Light Emitting Device (OLED) fabricated using the stacked configuration of LiF/Alq3/CBP-Ir (ppy) 3/α-NPD/F4-TCNQ by the Vacuum Thermal Evaporation Technique. A Keithley 2400 source meter was used for I-V characterization, and a Luminance meter (LMT L1009) was used for L-V characterization. The I-V characterization findings demonstrate that at low voltages of about 10 volts, the OLED emits neonish green light, which is correlated to the type of organic material used as an emissive layer, however as the voltage is increased further, the current increases, exhibiting nonlinearity up to 20 volts. Further increments in voltage do not achieve the desired outcomes, but instead produce heat as a result of non-radiative processes such as thermal relaxation of excitons, photon absorption, or internal reflection, which are undesirable and shorten the life of a device. Pixels were completely burned off after a certain amount of applied voltage was reached. The device yielded the highest luminance of 30551cd.m-2 at 20 volts, according to the L-V characterization results.
Detection of unknown primary neuroendocrine tumors (CUP-NET) using 68Ga DOTA-NOC receptor PET/CT (2009)

4599 Background: This bi-centric study aimed at determining the role of receptor PET/CT using 68 Ga-DOTA-NOC in the detection of undiagnosed primary sites of neuroendocrine tumours (NETs). Methods: Overall 59 patients (M: F 33:26, age 65±9 yr) with documented NET and unknown primary, were enrolled. PET/CT was performed after injection of approximately 100 MBq (46–260 MBq) of 68 Ga-DOTA-NOC. The maximum standardised uptake values (SUVmax) were calculated and compared with SUVmax in known pancreatic NET (pNET) and ileum / jejunum / duodenum (SI-NET). The results of PET/CT were also correlated with CT alone. Results: In 35/59 (59%) of patients, 68 Ga-DOTA-NOC PET/CT localised the site of the primary: ileum/jejunum (14), pancreas (16), rectum (2), lungs (2) and paraganglioma (1). CT alone (on retrospective analyses) confirmed the findings in 12/59 (20%) patients. The mean SUVmax of identified previously unknown pNET and SI-Net were 18.6 ± 9.8 (range 7.8–34.8) and 9.1± 6.0 (range 4.2–27.8), respectively. SUVmax in patients with previously known pNET and SI-NET were 26.1± 14.5 (range 8.7–42.4) and 11.3±3.7 (range 5.6- 17.9). The SUVmax of the unknown pNET and SI-NET were significantly lower (p&lt; 0.05) as compared to the ones with known primary tumour sites. 19% of the patients had high grade, and 81% low grade NET. In 4/59 patients the primary tumour was subsequently resected (2 pancretic, one ileal and one rectal tumour). Conclusions: Our data indicate that 68 Ga- DOTA-NOC PET/CT is highly superior to 111 In Octreoscan (17% detection rate for CUP according to literature) and can play a major role in the management of patients with CUP-NET. No significant financial relationships to disclose.
The Oscillatory Basis of Fitts’ Law (2019)

P. M. Fitts claimed that it expressed an intrinsic limitation of information-transmission capacity of the CNS. This analysis is prima facie evidence that the much replicated Fitts’ Law may be explainable in terms of self-organizing oscillatory processes of the motor system. Fitts investigated these variables using an experimental paradigm in which movement distance and target width are manipulated and movement time is the dependent measure. Given the post-hoc nature of the preceding, an experiment was performed to determine whether Fitts’ law can be replicated in a more oscillatory task and whether the fit of the model parameters for different target sizes replicates across participants. From a dynamics perspective that views the CNS embodying natural law, Y. Guiard has argued that self-organizing oscillatory processes play a role in the space/time/accuracy relation of Fitts’ law.
Identifying the Interactions That Allow Separation of O2 from N2 on the Open Iron Sites of Fe2(dobdc) (2015)

The presence of open metal sites along with a high porosity makes the Fe2(dobdc) metal–organic framework, also called Fe-MOF-74, particularly well suited for separating gaseous mixtures. For instance, since Fe2(dobdc) adsorbs O2 more strongly than N2, it can, in principle, be used to separate O2 from air [Bloch et al. J. Am. Chem. Soc. 2011, 133, 14814]. In the present work, we investigate the reversible differential adsorption of N2 and O2 on Fe2(dobdc) with Kohn–Sham density functional theory applied to an 88-atom cluster model of the MOF. The cluster is chosen such that it is large enough to allow an accurate description of the most important contributions to the binding enthalpies and small enough to perform high-level quantum mechanical calculations. For the quantum mechanical calculations, we use well-validated exchange–correlation functionals to study the ground-state structures of the Fe–N2 and Fe–O2 interacting systems. The calculations agree with experiment in that O2 binds more strongly than N2, and they reveal that the ground-state structure of the Fe–O2 subsystem has the dioxygen unit in a triplet spin state ferromagnetically coupled to the high-spin state (quintet state) of the iron center. Charge Model 5 (CM5) calculations have been performed to determine the partial atomic charges on the adsorbate molecules and the iron atom, and they show that charge transfer from the open iron(II) site is more important in the case of O2 than in the case of N2. Furthermore, bond orders, vibrational frequencies, and orbital energies were calculated to rationalize the stronger binding of O2 compared to N2 on Fe2(dobdc).
Effects of N-acetyl-glucosamine-coated glycodendrimers as biological modulators in the B16F10 melanoma model in vivo (2014)

Glyco-coat changes on cancer cells due to aberrant glycosylation are potential targets for immune recognition through lectin-like receptors on immune cells. These cells include natural killer (NK), CD8+ and CD4+ lymphocytes, all reported to have, together with cytokines, important functions in antitumor immunity. The aim of this study was to evaluate a possible role of synthetic monodisperse multivalent neo-glycoconjugates, namely glycodendrimers, as a new approach to anticancer immune modulation through carbohydrate-mediated immune recognition. Octavalent polyamidoamine dendrimers functionalized with N-acetyl-glucosamine residues (PAMAM-GlcNAc8), with in vitro high affinity for the recombinant lymphocyte receptor NKR-P1A, were employed. To follow the fate of the compound, a fluorescent marker was conjugated to the tetra-branched semi-component of the dendrimer. Tumor development and immunity were evaluated in C57BL/6 mice. Animals were inoculated with B16F10 melanoma cells and underwent different protocols of PAMAM-GlcNAc8 administration. Advantages on survival and reduction of tumor growth were obtained in dose-dependent manner, by IP route. Increase of CD69+ cells in the spleen and their appearance inside the tumors, early progressive release of IL-1beta, a later production of INFgamma and IL-2 concomitant to an increment of CD4+ cells were observed. Cytotoxicity assays, performed ex vivo, showed an enhanced NK cell activity proportioned to the percentage of activated NK cells. Our data suggest that well-defined multivalent neo-glycoconjugates can stimulate an antitumor immune response engaging both innate and acquired immunity.