gebhart/patrepeval huggingface dataset:
Propionibacterium acnes phylogenetic type III is associated with progressive macular hypomelanosis (2017)

Progressive macular hypomelanosis (PMH) is a skin disorder that is characterized by hypopigmented macules and usually seen in young adults. The skin microbiota, in particular the bacterium <i>Propionibacterium acnes</i>, is suggested to play a role. Here, we compared the <i>P. acnes</i> population of 24 PMH lesions from eight patients with corresponding nonlesional skin of the patients and matching control samples from eight healthy individuals using an unbiased, culture-independent next-generation sequencing approach. We also compared the <i>P. acnes</i> population before and after treatment with a combination of lymecycline and benzoylperoxide. We found an association of one subtype of <i>P. acnes</i>, type III, with PMH. This type was predominant in all PMH lesions (73.9% of reads in average) but only detected as a minor proportion in matching control samples of healthy individuals (14.2% of reads in average). Strikingly, successful PMH treatment is able to alter the composition of the <i>P. acnes</i> population by substantially diminishing the proportion of <i>P. acnes</i> type III. Our study suggests that <i>P. acnes</i> type III may play a role in the formation of PMH. Furthermore, it sheds light on substantial differences in the <i>P. acnes</i> phylotype distribution between the upper and lower back and abdomen in healthy individuals.
Spectroscopic characterization of 6‐hydroxy and 1‐methyl‐6‐hydroxybicyclo[2.2.2]octan‐2‐one ethylene acetals and ethylene dithioacetals (2007)

6-endo- and 6-exo-Hydroxybicyclo[2.2.2]octan-2-one and 1-methyl-6-endo- and 6-exo-hydroxybicyclo[2.2.2]octan-2-one ethylene acetals and ethylene dithioacetals 1-4 have been characterized by 1D and 2D NMR methods.
A Taxonomy of Multiple Window Coordinations (1998)

In current windowing environments, individual windows are treated independently, making it difficult for users to coordinate information across multiple windows. While coordinated multi-window strategies are increasingly used in visualization and web user interfaces, designs are inflexible and haphazard. The space of such linkedwindow strategies is not well understood and largely unexplored. This paper presents a taxonomy of coordinations, identifies important components, and reviews example interfaces. This 2x3 taxonomy provides guidelines for designers of applications, user interface toolkits, and window managers. We hope to encourage construction of generalized, end-user programmable, robust, multiple-window coordination capabilities. KEYWORDS User Interface, Coordination, Taxonomy, Multiple Window Strategies, Information Visualization,Window Management INTRODUCTION Users are dealing with increasing quantity, variety, and interrelated-ness of information. User tasks are becoming...
Lipoprotein Abnormalities in Well-Treated Type II Diabetic Patients (1993)

Type II diabetic patients in good to fair metabolic control are characterized by minor alterations of the plasma lipids, but LDL and HDL triglycerides, apoB, and apoCIII are increased, thus indicating that the lipoprotein composition is altered, possibly because of an abnormal triglyceride metabolism and/or lipid transfer activity.
Galectin-1 Reduces the Severity of Herpes Simplex Virus-Induced Ocular Immunopathological Lesions (2012)

Stromal keratitis is a chronic immunopathological lesion of the eye caused by HSV-1 infection that can result in blindness. Because the inflammatory lesions are primarily orchestrated by Th1 cells, and to a lesser extent by Th17 cells, inhibiting their activity represents a useful form of therapy. In this study we evaluated the therapeutic potential of galectin-1 (gal-1), an endogenous lectin that in some autoimmune diseases was shown to suppress the functions of Th1 and Th17 cells. Treatment was begun at different times after ocular infection with HSV and the outcome was assessed clinically as well as for effects on various immune parameters. Treatment with recombinant gal-1 significantly diminished stromal keratitis lesion severity and the extent of corneal neovascularization. Treated mice had reduced numbers of IFN-γ- and IL-17-producing CD4(+) T cells, as well as neutrophil infiltration in the cornea. Furthermore, disease severity was greater in gal-1 knockout mice compared with their wild-type counterparts. The many effects of gal-1 treatment include reduction in the production of proinflammatory cytokines and chemokines, increased production of IL-10, and inhibitory effects on molecules involved in neovascularization. To our knowledge, our findings are the first to show that gal-1 treatment represents a useful approach to control lesion severity in a virally induced immunopathological disease.
MOLECULAR AND BIOLOGIC CHARACTERISTICS OF TOXOPLASMA GONDII ISOLATES FROM WILDLIFE IN THE UNITED STATES (2004)

Toxoplasma gondii isolates can be grouped into 3 genetic lineages. Type I isolates are considered more virulent in outbred mice and have been isolated predominantly from clinical cases of human toxoplasmosis, whereas types II and III isolates are considered less virulent for mice and are found in humans and food animals. Little is known of genotypes of T. gondii isolates from wild animals. In the present report, genotypes of isolates of T. gondii from wildlife in the United States are described. Sera from wildlife were tested for antibodies to T. gondii with the modified agglutination test, and tissues from animals with titers of 1:25 (seropositive) were bioassayed in mice. Toxoplasma gondii was isolated from the hearts of 21 of 34 seropositive white-tailed deer (Odocoileus virginianus) from Mississippi and from 7 of 29 raccoons (Procyon lotor); 5 of 6 bobcats (Lynx rufus); and the gray fox (Urocyon cinereoargenteus), red fox (Vulpes vulpes), and coyote (Canis latrans) from Georgia. Toxoplasma gondii was also isolated from 7 of 10 seropositive black bears (Ursus americanus) from Pennsylvania by bioassay in cats. All 3 genotypes of T. gondii based on the SAG2 locus were circulating among wildlife.
Synthesis and nuclear magnetic resonance spectra of nitrogen-15-enriched sulfur-nitrogen compounds (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and nuclear magnetic resonance spectra of nitrogen-15-enriched sulfur-nitrogen compoundsTristram Chivers, Richard T. Oakley, Otto J. Scherer, and Gotthelf WolmershaeuserCite this: Inorg. Chem. 1981, 20, 3, 914–917Publication Date (Print):March 1, 1981Publication History Published online1 May 2002Published inissue 1 March 1981https://pubs.acs.org/doi/10.1021/ic50217a055https://doi.org/10.1021/ic50217a055research-articleACS PublicationsRequest reuse permissionsArticle Views134Altmetric-Citations48LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The 1988-1989 Drought in Illinois: causes, dimensions, and impacts (1982)

The 1988-1989 drought was one of the most disastrous droughts in the history of the state. Hydrologic, meteorological, and climatological aspects of the 1988-1989 drought in Illinois are addressed. The drought is evaluated in terms of precipitation, streamflow, lakes and reservoirs, and ground-water resources of the state. The meteorological conditions that produced the drought also are addressed. Impacts and problems resulting from the drought are discussed along with various actions taken to ameliorate the problems. Although the primary goal of the study was to quantify the drought, primarily in a physical sense, an important secondary goal was to assess the impacts and the actions employed in order to derive information needed in future planning and handling of Illinois droughts. The report thus ends with a set of recommendations for coping with future droughts.
Unintentional Insider Threat: Contributing Factors, Observables, and Mitigation Strategies (2014)

Organizations often suffer harm from individuals who bear them no malice but whose actions unintentionally expose the organizations to risk in some way. This paper examines initial findings from research on such cases, referred to as unintentional insider threat (UIT). The goal of this paper is to inform government and industry stakeholders about the problem and its possible causes and mitigation strategies. As an initial approach to addressing the problem, we developed an operational definition for UIT, reviewed research relevant to possible causes and contributing factors, and provided examples of UIT cases and their frequencies across several categories. We conclude the paper by discussing initial recommendations on mitigation strategies and countermeasures.
S2851 Muscle-Retracting Sign During Colorectal Endoscopic Submucosal Dissection (2022)

Introduction: Endoscopic submucosal dissection (ESD) allows for en-bloc resection of large early-stage gastrointestinal tumors. During the submucosal dissection of colorectal polyps, the muscle layer can be found to extend into the polyp, this is termed as Muscle-Retracting Sign. This endoscopic sign requires a high index of suspicion to prevent inadvertent dissection of the muscle layer. This case demonstrates the first reported case in the US of the Muscle-Retracting sign identified during colorectal endoscopic submucosal dissection (ESD) of a large adenoma. Case Description/Methods: A 74-year-old male presented for routine colon cancer screening and was found to have a 5cm pedunculated sigmoid colon polyp. Biopsy of the polyp revealed tubular adenoma with high-grade dysplasia with mucosal prolapse-type changes. Given the endoscopic impression of the mass lesion, a more advanced pathology could not be ruled out. The patient was planned to undergo ESD through the stalk of the large polyp. Submucosal dissection was performed using a dual and IT knife. In the center of the tumor stalk, muscle retraction sign was seen, with the muscular propria being pulled towards the center of the polyp. The procedure was stopped due to the risk of muscle perforation. The patient went home after the procedure, was doing well on follow up and had no adverse events. Given the high-grade dysplasia, the patient was referred to surgery for resection. (Figure) Discussion: Some colorectal neoplastic lesions can have the muscle layer drawn toward the center of the neoplasm. Previous studies in Japan have shown lesions positive with MR sign, have a significantly lower successful resection rate. These lesions should be carefully dissected and elective surgical resection should be considered if appropriate.Figure 1.: Colorectal ESD of 5 cm pedunculated sigmoid colon polyp (1A), showing the Muscle Retraction Sign (1B).
Influence of Biophysical Parameters on Maintaining the Mesenchymal Stem Cell Phenotype (2015)

The maintenance of the mesenchymal stem cell (MSC) phenotype in vivo is influenced by the precise orchestration of biochemical and biophysical signals in the stem cell "niche". However, when MSCs are removed from the body and expanded in vitro, there is a loss of multipotency. Here, we employ micropatterned hydrogels to explore how biophysical cues influence the retention of MSC multipotency marker expression. At the single-cell level, soft substrates and patterns that restrict spreading and cytoskeletal tension help maintain the expression of MSC markers. When MSCs are patterned in multicellular geometries, both high cell density and regions of low tension within the pattern are shown to assist the maintenance of multipotency. Combining experiment and simulation along with cytoskeleton disrupting agents reveals spatial patterns of cytoskeletal tension in multicellular architectures that guides the expression of markers associated with MSC multipotency. These findings uncover a relationship between multiple biophysical parameters in maintaining the MSC phenotype, which may shed light on the structure of the MSC "niche" and prove useful in guiding the selection of in vitro expansion materials for regenerative therapies.
Peak systolic over protodiastolic ratio as an objective substitute for the uterine artery notch (1996)

Although there is no definitive definition of the notch, its detection is reproducible within a center. However, published prevalences between centers in unselected populations vary. The measure of the A/C ratio can serve as an objective substitute.
SiO2/Si interfacial structure on vicinal Si(100) studied with second-harmonic generation (1993)

Surface second-harmonic generation (SHG) has been used to reveal the symmetry characteristics of buried interfaces on oxidized vicinal Si(100). For native oxides, onefold and threefold symmetries are prominent, arising from the presence of steps and ordered Si-O bonds in the vicinity of the steps, respectively. For thermal oxides grown at 900 \ifmmode^\circ\else\textdegree\fi{}C, twofold symmetry is most prominent, consistent with the presence of highly oriented microcrystallites at the buried interface. SHG measurements of postoxidation annealing of oxides grown in steam are consistent with the amount of stress reduction occurring as a result of annealing being too small to be observed by SHG, and with hydrogen leaving the buried interface below 600 \ifmmode^\circ\else\textdegree\fi{}C.
Probabilistic Hosting Capacity Analysis via Bayesian Optimization (2020)

This paper studies the probabilistic hosting capacity analysis (PHCA) problem in distribution networks considering uncertainties from distributed energy resources (DERs) and residential loads. PHCA aims to compute the hosting capacity, which is defined as the maximal level of DERs that can be securely integrated into a distribution network while satisfying operational constraints with high probability. We formulate PHCA as a chance-constrained optimization problem, and model the uncertainties from DERs and loads using historical data. Due to non-convexities and a substantial number of historical scenarios being used, PHCA is often formulated as large-scale nonlinear optimization problem, thus computationally intractable to solve. To address the core computational challenges, we propose a fast and extensible framework to solve PHCA based on Bayesian Optimization (BayesOpt). Comparing with state-of-the-art algorithms such as interior point and active set, numerical results show that the proposed BayesOpt approach is able to find better solutions (25% higher hosting capacity) with 70% savings in computation time on average.
Development of a microminiature sorption cooler (1997)

A microminiature sorption cooler is under development for cooling of small low-temp. electronic devices with a cooling power in the range of 10 mW at 80 K. A thermodn. study shows that a carbon/xenon cooler with thermo-elec. precooling of the gas can be used as a first stage that cools to 165 K with a COP of about 3.5 %. A prototype compressor cell with a length of 5 cm and a diam. of 5 mm is described. In this cell a gas-gap heat switch is applied. [on SciFinder (R)]
Green–Blue Emitters: NHC‐Based Cyclometalated [Pt(C^C*)(acac)] Complexes (2010)

White on target: Platinum(II) complexes with cyclometalated 1-phenylimidazole ligands (see picture: R=2,3-OC6H4) show photophysical properties in the blue region of the visible spectrum, thus giving them the potential to be used as the blue component of white-light-emitting diodes. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Supplementary Figures and Table from Acetylsalicylic Acid Governs the Effect of Sorafenib in <i>RAS</i>-Mutant Cancers (2023)

&lt;p&gt;Supplementary Figure 1, Sorafenib in combination with aspirin but not COX1/2 inhibitors synergistically induces cell death in RAS or RAF mutant cancer cell lines. Supplementary Figure 2, the combination of sorafenib/aspirin activates ERK and AMPK signalling after 4 hours of drug exposure. Supplementary Figure 3, MEK, pan-RAF and AMPK inhibitors diminish sorafenib/aspirin induced cell death. Supplementary Figure 4, high concentrations of dabrafenib in combination with aspirin reduces cell viability in RAS mutant cancer cells. Supplementary Figure 5, immunohistochemistry of phosphor-ERK in A549 xenografts treated with vehicle, sorafenib, aspirin or combined sorafenib/aspirin. Supplementary Table 1, list of used antibodies.&lt;/p&gt;
Guaranteed scheduling for switches with configuration overhead (2003)

We present three algorithms that provide performance guarantees for scheduling switches, such as optical switches, with configuration overhead. Each algorithm emulates an unconstrained (zero overhead) switch by accumulating a batch of configuration requests and generating a corresponding schedule for a constrained switch. Speedup is required both to cover the configuration overhead of the switch and to compensate for empty slots left by the scheduling algorithm. Scheduling algorithms are characterized by the number of configurations N/sub s/ they require to cover a batch of requests and the speedup required to compensate for empty slots S/sub min/. Initially, all switch reconfiguration is assumed to occur simultaneously. We show that a well-known exact matching algorithm, EXACT, leaves no empty slots (i.e., S/sub min/=1), but requires N/sub s//spl ap/N/sup 2/ configurations for an N-port switch leading to high configuration overhead or large batches and, hence, high delay. We present two new algorithms that reduce the number of configurations required substantially. MIN covers a batch of requests in the minimum possible number of configurations, N/sub s/=N, but at the expense of many empty slots, S/sub min//spl ap/4log/sub 2/N. DOUBLE strikes a balance, requiring twice as many configurations, N/sub s/=2N, while reducing the number of empty slots so that S/sub min/=2. Loosening the restriction on reconfiguration times, the scheduling problem is cast as an open shop. The best known practical scheduling algorithm for open shops, list scheduling (LIST), gives the same emulation requirements as DOUBLE. Therefore, we conclude that our architecture gains no advantages from allowing arbitrary switch reconfiguration. Finally, we show that DOUBLE and LIST offer the lowest required speedup to emulate an unconstrained switch across a wide range of port count and delay.
Effect of the Ligand Structure on Chemical Vapor Deposition of WNxCy Thin Films from Tungsten Nitrido Complexes of the Type WN(NR2)3 (2015)

Tungsten nitrido complexes of the type WN(NR2)3 [NR2 = combinations of NMe2, NEt2, NiPr2, NnPr2, NiBu2, piperidine, and azepane] were synthesized as precursors for aerosol-assisted chemical vapor deposition of WNxCy thin films. The effects of the amido substituents on precursor volatility and decomposition were evaluated experimentally and computationally. Films deposited using WN(NMe2)(NiPr2)2 as a single-source precursor were assessed as diffusion barrier materials for Cu metallized integrated circuits in terms of growth rate, surface roughness, composition, and density. In diffusion barrier tests, Cu (∼100 nm)/WNxCy (∼5 nm)/Si samples prepared from WN(NMe2)(NiPr2)2 were annealed for 30 min at 500 °C and successfully blocked Cu penetration according to four-point probe, X-ray diffraction, scanning electron microscopy etch-pit test, and high-resolution transmission electron microscopy measurements.
Absolute Rate Constants for Hydrocarbon Autoxidation. XXII. The Autoxidation of some Vinyl Compounds (1972)

Absolute propagation and termination rate constants have been determined for the autoxidation of some vinyl compounds at 30°. Rates of propagation depend on the structure of both the peroxy radical and the vinyl compound. The reactivity of peroxy radicals towards addition increases as the electron-withdrawing capacity of the α-substituent increases. Rate constants for addition of t-butylperoxy radicals to vinyl compounds, [Formula: see text] fit the equation[Formula: see text]where E s is the estimated stabilization energy of the β-peroxyalkyl radical (in kcal/mol) formed in the addition reaction.
Long‐Term Captopril in Young and Old Patients with Mild Hypertension (1991)

The decrease in renal blood flow (RBF) observed in patients with hypertension can be increased with converting enzyme inhibition (CEI). It is unknown whether the decrease in RBF observed with age can also be increased with CEI. This study compared the short- and long-term effects of captopril monotherapy in young (less than 50 years) and old (greater than 65 years) hypertensive patients. Captopril effectively decreased blood pressure in both groups (diastolic blood pressure less than 90 mm Hg), with the young patients requiring a lower dose (.7 mg/kg) than the elderly patients (1.2 mg/kg). Creatinine and para-aminohippurate clearances were maintained in both groups, with a decrease in renal vascular resistance being observed in the younger patients. Serum aldosterone levels fell significantly after each dose of captopril at all phases of the study, with no change observed in plasma renin levels. Atrial natriuretic peptide (ANP) level was increased in the elderly patients receiving placebo (48.8 +/- 8 pg/mL) when compared with the young subjects (24 +/- 3.8 pg/mL). Captopril did not alter ANP levels in either group.
[Preeclampsia resulting from placental defects: biology to clinical considerations]. (1997)

L'implantation embryonnaire et la formation du placenta humain reposent sur des mecanismes cellulaires et moleculaires complexes mettant en oeuvre un dialogue entre les cellules trophoblastiques foetales et les tissus maternels. Ces interactions sont mediees par divers messagers chimiques solubles et insolubles. Ces conversations cellulaires font intervenir non seulement les cellules trophoblastiques foetales et les cellules residentes de l'endometre mais egalement les cellules du systeeme immunitaire maternel. C'est donc d'un dialogue structure et harmonieux que resultera le succes de l'implantation, Nombreux sont probablement les niveaux de perturbations de ces messagers qui conduisent a la cacophonie, et donc a la fausse couche. La definition precise des mecanismes fondamentaux de l'implantation et de la placentation constitue ainsi un atout decisif dans le design des approches contraceptives nouvelles, dans la prevention et le traitement des echecs d'implantation et dans la prophylaxie des fausses couches spontanees a repetition.