gebhart/patrepeval huggingface dataset:
Data from Dual Targeting of Tumor Angiogenesis and Chemotherapy by Endostatin–Cytosine Deaminase–Uracil Phosphoribosyltransferase (2023)

&lt;div&gt;Abstract&lt;p&gt;Several antiangiogenic drugs targeting VEGF/VEGF receptor (VEGFR) that were approved by the Food and Drug Administration for many cancer types, including colorectal and lung cancer, can effectively reduce tumor growth. However, targeting the VEGF signaling pathway will probably influence the normal function of endothelial cells in maintaining homeostasis and can cause unwanted adverse effects. Indeed, emerging experimental evidence suggests that VEGF-targeting therapy induced less tumor cell–specific cytotoxicity, allowing residual cells to become more resistant and eventually develop a more malignant phenotype. We report an antitumor therapeutic EndoCD fusion protein developed by linking endostatin (Endo) to cytosine deaminase and uracil phosphoribosyltransferase (CD). Specifically, Endo possesses tumor antiangiogenesis activity that targets tumor endothelial cells, followed by CD, which converts the nontoxic prodrug 5-fluorocytosine (5-FC) to the cytotoxic antitumor drug 5-fluorouracil (5-FU) in the local tumor area. Moreover, selective targeting of tumor sites allows an increasing local intratumoral concentration of 5-FU, thus providing high levels of cytotoxic activity. We showed that treatment with EndoCD plus 5-FC, compared with bevacizumab plus 5-FU treatment, significantly increased the 5-FU concentration around tumor sites and suppressed tumor growth and metastasis in human breast and colorectal orthotropic animal models. In addition, in contrast to treatment with bevacizumab/5-FU, EndoCD/5-FC did not induce cardiotoxicity leading to heart failure in mice after long-term treatment. Our results showed that, compared with currently used antiangiogenic drugs, EndoCD possesses potent anticancer activity with virtually no toxic effects and does not increase tumor invasion or metastasis. Together, these findings suggest that EndoCD/5-FC could become an alternative option for future antiangiogenesis therapy. &lt;i&gt;Mol Cancer Ther; 10(8); 1327–36. ©2011 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Benefits and Application of a Surface-Controlled Sliding Sleeve for Fracturing Operations (2011)

Abstract Recent improvements in fracturing technologies have allowed access to tight formations that previously were considered unprofitable. The most common of these technologies is a ball-drop-actuated sliding sleeve that allows operators to economically isolate and fracture ten to twenty zones in a single well. While these technologies have been well proven, there are still drawbacks such as: Each zone requires a drop in the production string ID The zones must be stimulated beginning at the toe and ending at the heel Many applications require milling-out of ball seats after fracturing When possible to move sleeves after fracing, a workover is required. A system has been developed to alleviate these limitations. This system includes well profile and isolation similar to the ball-drop sliding sleeve system but offers control of the sliding sleeves from the surface. This eliminates the cost and downtime of intervention. The system consists of an ICV (interval control valve) that has been optimized for fracturing applications. It is essentially an intelligent completion method that can withstand the extreme environment of a frac application. This allows the operator to frac the zones in any order, re-frac at a later date, close zones to allow pressure to build, eliminate water cut, and conduct transient pressure analysis of any zone without the necessity of a workover. This paper discusses the use of surface-controlled sliding sleeves in frac-pack operations and the benefits that an operator can realize by installing the new sliding sleeves in tight formations.
Visual-LiDAR Odometry Aided by Reduced IMU (2016)

This paper proposes a method for combining stereo visual odometry, Light Detection And Ranging (LiDAR) odometry and reduced Inertial Measurement Unit (IMU) including two horizontal accelerometers and one vertical gyro. The proposed method starts with stereo visual odometry to estimate six Degree of Freedom (DoF) ego motion to register the point clouds from previous epoch to the current epoch. Then, Generalized Iterative Closest Point (GICP) algorithm refines the motion estimation. Afterwards, forward velocity and Azimuth obtained by visual-LiDAR odometer are integrated with reduced IMU outputs in an Extended Kalman Filter (EKF) to provide final navigation solution. In this paper, datasets from KITTI (Karlsruhe Institute of Technology and Toyota technological Institute) were used to compare stereo visual odometry, integrated stereo visual odometry and reduced IMU, stereo visual-LiDAR odometry and integrated stereo visual-LiDAR odometry and reduced IMU. Integrated stereo visual-LiDAR odometry and reduced IMU outperforms other methods in urban areas with buildings around. Moreover, this method outperforms simulated Reduced Inertial Sensor System (RISS), which uses simulated wheel odometer and reduced IMU. KITTI datasets do not include wheel odometry data. Integrated RTK (Real Time Kinematic) GPS (Global Positioning System) and IMU was replaced by wheel odometer to simulate the response of RISS method. Visual Odometry (VO)-LiDAR is not only more accurate than wheel odometer, but it also provides azimuth aiding to vertical gyro resulting in a more reliable and accurate system. To develop low-cost systems, it would be a good option to use two cameras plus reduced IMU. The cost of such a system will be reduced than using full tactical MEMS (Micro-Electro-Mechanical Sensor) based IMUs because two cameras are cheaper than full tactical MEMS based IMUs. The results indicate that integrated stereo visual-LiDAR odometry and reduced IMU can achieve accuracy at the level of state of art.
Intra-abdominal adhesions: Cellular mechanisms and strategies for prevention (2011)

Postoperative intra-abdominal adhesions represent a serious clinical problem. In this review, we have focused on recent progress in the cellular and humoral mechanisms underpinning adhesion formation, and have reviewed strategies that interfere with these pathways as a means to prevent their occurrence. Current and previous English-language literature on the pathogenesis of adhesion formation was identified. As the burden of surgical disease in the world population increases, and the frequency of reoperation increases, prevention of adhesion formation has become a pressing goal in surgical research.
An Enhanced IEEE 1588 Time Synchronization for Asymmetric Communication Link in Packet Transport Network (2010)

IEEE 1588 is a standard to synchronize independent clocks running on separate nodes of a distributed measurement and control system. In PTN (Packet Transport Network), it is considered as a key technology for supporting legacy TDM services and synchronizing 3G base stations. However, conventional IEEE 1588 synchronization algorithm assumes symmetrical links, and makes errors for asymmetric links for the calculation of the time difference between the master clock and the slave clock. We proposed an enhanced time synchronization method to calculate the time difference and the proposed method enhances an accuracy of the time synchronization.
Reply to B.O. Anderson et al (2016)

Stratified Clinical Practice Guideline." 2 We welcome Anderson and Duggan's 1 appreciation of the new ASCO resource-stratified guidelines and gratefully acknowledge the pioneering role of the Breast Health Global Initiative (BHGI) in resource-stratified guideline development.BHGI's leadership has enriched the sources of guidance for clinicians, policy makers, and others.ASCO was fortunate and pleased to partner with and participate in BHGI as described by Anderson and Duggan, 1 including the participation by individual ASCO members in BHGI.We thank them for kindly providing the historic note on ASCO's participation, to which we add ASCO's role in the BHGI Alliance 2012/ 2013 and 2010/2011. 3derson and Duggan 1 state that ASCO Expert Panel authors "have incorrectly attributed their resource-stratification methodology to the World Health Organization (WHO) rather than to BHGI, and that they have also incorrectly cited the peerreview publications describing the concepts of resource stratification that they have applied to the management of invasive cervical cancer." 1 They state that this concept should properly be attributed to BHGI, which was the first to develop, test, and validate the concept of a four-tiered resource stratification.
Incidence of gammopathies in long‐term plasmapheresis donors at Canadian Blood Services (2015)

The incidence of Mc gammopathies (2.41 per 1000 donors) did not significantly increase from 2004 to 2012. Older donors had a higher incidence of Mc gammopathies and longer donation periods than their healthy counterparts. Overall, gammopathy rates were below those reported over the same age range in the general population.
The Muscle Morphology of Elite Sprint Running (2020)

ABSTRACT The influence of muscle morphology and strength characteristics on sprint running performance, especially at elite level, is unclear. Purpose This study aimed to investigate the differences in muscle volumes and strength between male elite sprinters, sub-elite sprinters, and untrained controls and to assess the relationships of muscle volumes and strength with sprint performance. Methods Five elite sprinters (100-m season’s best equivalent [SBE 100 ], 10.10 ± 0.07 s), 26 sub-elite sprinters (SBE 100 , 10.80 ± 0.30 s), and 11 untrained control participants underwent 1) 3-T magnetic resonance imaging scans to determine the volume of 23 individual lower limb muscles/compartments and 5 functional muscle groups and 2) isometric strength assessment of lower body muscle groups. Results Total lower body muscularity was distinct between the groups (controls &lt; sub-elite +20% &lt; elite +48%). The hip extensors exhibited the largest muscle group differences/relationships (elite, +32% absolute and +15% relative [per kg] volume, vs sub-elite explaining 31%–48% of the variability in SBE 100 ), whereas the plantarflexors showed no differences between sprint groups. Individual muscle differences showed pronounced anatomical specificity (elite vs sub-elite absolute volume range, +57% to −9%). Three hip muscles were consistently larger in elite vs sub-elite (tensor fasciae latae, sartorius, and gluteus maximus; absolute, +45%–57%; relative volume, +25%–37%), and gluteus maximus volume alone explained 34%–44% of the variance in SBE 100 . The isometric strength of several muscle groups was greater in both sprint groups than controls but similar for the sprint groups and not related to SBE 100 . Conclusions These findings demonstrate the pronounced inhomogeneity and anatomically specific muscularity required for fast sprinting and provides novel, robust evidence that greater hip extensor and gluteus maximus volumes discriminate between elite and sub-elite sprinters and are strongly associated with sprinting performance.
The p42 variant of ETS1 protein rescues defective Fas-induced apoptosis in colon carcinoma cells (1999)

ETS1 is a cellular homologue of the product of the viral ets oncogene of the E26 virus, and it functions as a tissue-specific transcription factor. It plays an important role in cell proliferation, differentiation, lymphoid cell development, transformation, angiogenesis, and apoptosis. ETS1 controls the expression of critical genes involved in these processes by binding to ets binding sites present in the transcriptional regulatory regions. The ETS1 gene generates two proteins, p51 and a spliced variant, p42, lacking exon VII. In this paper we show that p42-ETS1 expression bypasses the damaged Fas-induced apoptotic pathway in DLD1 colon carcinoma cells by up-regulating interleukin 1beta-converting enzyme (ICE)/caspase-1 and causes these cancer cells to become susceptible to the effects of the normal apoptosis activation system. ICE/caspase-1 is a redundant system in many cells and tissues, and here we demonstrate that it is important in activating apoptosis in cells where the normal apoptosis pathway is blocked. Blocking ICE/caspase-1 activity by using specific inhibitors of this protease prevents the p42-ETS1-induced apoptosis from occurring, indicating that the induced ICE/caspase-1 enzyme is responsible for killing the cancer cells. p42-ETS1 activates a critical alternative apoptosis pathway in cancer cells that are resistant to normal immune attack, and thus it may be useful as an anticancer therapeutic.
Synthesis and Characterization of Thermally Stable Blue Light-Emitting Polyfluorenes Containing Siloxane Bridges (2003)

The first novel polyfluorene copolymers containing siloxane bridges were synthesized by Ni(0)-mediated copolymerization between 2,7-dibromo-9,9‘-dihexylfluorene and a bridged fluorene monomer containing siloxane linkages. Two such bridged copolymers were prepared: PSiloBg1 (containing 1 mol % siloxane-bridged fluorene unit) and PSiloBg3 (containing 3 mol % siloxane-bridged fluorene unit). PSiloBg1 and PSiloBg3 exhibited good solubility in common organic solvents, thermal stability up to 420 °C, and facile film formation. The glass transition temperatures of the bridged polymers (106 and 110 °C, respectively) were higher than that of the homo poly(dihexylfluorene) (PDHF). In particular, PSiloBg3 exhibited a polymerization yield (96%) and a molecular weight (MW = 185 000) higher than those of PDHF (polymerization yield = 62%, MW = 82 000). Interestingly, after the bridged polymers had been annealed at 150 °C for 4 h in air, their PL spectra showed no significant increase in vibronic structures at 450 and 475 nm and no evidence of aggregation formation and excimers at wavelengths of >500 nm. In addition, the full width at half-maximum (fwhm) of the bridged polymers was very small (fwhm = 51−52 nm) compared to that of PDHF (fwhm = 85 nm). Collectively, the results show that the polyfluorenes with siloxane bridges exhibit thermally stable almost pure blue emission, making these polymers promising candidate materials for device applications.
Characterisation of high current density resonant tunneling diodes for THz emission using photoluminescence spectroscopy (2016)

Resonant tunneling diodes (RTDs) provide high speed current oscillation which is applicable to THz generation when coupled to a suitably designed antenna. For this purpose, the InGaAs/AlAs/InP materials have been used, as this system offers high electron mobility, suitable band-offsets, and low resistance contacts. However for high current density operation (~MA/cm<sup>2</sup>) the epitaxial structure is challenging to characterize using conventional techniques as it consists of a single, very thin AlAs/InGaAs quantum well (QW). Here, we present a detailed low temperature photoluminescence spectroscopic study of high current density RTDs that allow the non-destructive mapping of a range of critical parameters for the device. We show how the doping level of the emitter/collector and contact layers in the RTD structure can be measured using the Moss-Burstein effect. For the full device structure, we show how emission from the QW may be identified, and detail how the emission changes with differing indium composition and well widths. We show that by studying nominally identical, un-doped structures, a type-II QW emission is observed, and explain the origin of the type-I emission in doped devices. This observation opens the way for a new characterization scheme where a “dummy” RTD active element is incorporated below the real RTD structure. This structure allows significantly greater control in the epitaxial process.
Control and Provisioning of Wireless Access Points (CAPWAP) Protocol Binding for IEEE 802.11 (2009)

Wireless LAN product architectures have evolved from single autonomous
access points to systems consisting of a centralized Access Controller
(AC) and Wireless Termination Points (WTPs). The general goal of
centralized control architectures is to move access control, including
user authentication and authorization, mobility management, and radio
management from the single access point to a centralized controller.
This specification defines the Control And Provisioning of Wireless
Access Points (CAPWAP) Protocol Binding Specification for use with the
IEEE 802.11 Wireless Local Area Network protocol. [STANDARDS-TRACK]
Intrinsic effects of double side collecting silicon solar cells (2011)

S.160-166
A Bayesian Approach for Estimating Dynamic Functional Network Connectivity in fMRI Data (2017)

Dynamic functional connectivity, i.e., the study of how interactions among brain regions change dynamically over the course of an fMRI experiment, has recently received wide interest in the neuroimaging literature. Current approaches for studying dynamic connectivity often rely on ad-hoc approaches for inference, with the fMRI time courses segmented by a sequence of sliding windows. We propose a principled Bayesian approach to dynamic functional connectivity, which is based on the estimation of time varying networks. Our method utilizes a hidden Markov model for classification of latent cognitive states, achieving estimation of the networks in an integrated framework that borrows strength over the entire time course of the experiment. Furthermore, we assume that the graph structures, which define the connectivity states at each time point, are related within a super-graph, to encourage the selection of the same edges among related graphs. We apply our method to simulated task-based fMRI data, where we show how our approach allows the decoupling of the task-related activations and the functional connectivity states. We also analyze data from an fMRI sensorimotor task experiment on an individual healthy subject and obtain results that support the role of particular anatomical regions in modulating interaction between executive control and attention networks.
Nonpeptide Angiotensin II Receptor Antagonists:  The Next Generation in Antihypertensive Therapy (1996)

ADVERTISEMENT RETURN TO ISSUEPerspectiveNEXTNonpeptide Angiotensin II Receptor Antagonists: The Next Generation in Antihypertensive TherapyRuth R. Wexler, William J. Greenlee, John D. Irvin, Michael R. Goldberg, Kristine Prendergast, Ronald D. Smith, and Pieter B. M. W. M. TimmermansView Author Information DuPont Merck Pharmaceutical Company, Wilmington, Delaware, and Merck Research Laboratories, Blue Bell, Pennsylvania, and Rahway, New Jersey Cite this: J. Med. Chem. 1996, 39, 3, 625–656Publication Date (Web):February 2, 1996Publication History Received27 June 1995Published online2 February 1996Published inissue 1 January 1996https://doi.org/10.1021/jm9504722Copyright © 1996 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views2407Altmetric-Citations248LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (1 MB) Get e-AlertsSUBJECTS:Anatomy,Antagonists,Peptides and proteins,Receptors,Rodent models Get e-Alerts
Ant colony inspired algorithm for adaptive traffic routing (2011)

In this paper we present a new dynamic nature inspired algorithm for the enhancement of routing in problematic parts of the road network affected by traffic jams, accidents and so on. The algorithm is intended to improve the quality of navigation in the critical sections of road network or in its parts affected by accidents. By the Ant Colony Algorithm we search for new up-to-date information characterizing each road in the network in or near the problematic area. We select start and end points and process the roads between them. The result of the optimization can be used for dynamic adaptation of the map information in traditional navigation systems.
Extending JSprit to solve electric vehicle routing problems with recharging (2022)

In this article, we present our adaptation of the Ruin-and-Recreate (R&R) algorithm to solve the electrical vehicle routing problem with time windows and multiple trips. We implement this adaptation in JSprit, an open-source vehicle routing problem solver. We implement the framework for a case study of Lyon, France. We assess the efficiency impact of adding charging constraints to a simulation of a fleet of autonomous delivery robots.
Fast latent semantic indexing of spoken documents by using self-organizing maps (2002)

This paper describes a new latent semantic indexing (LSI) method for spoken audio documents. The framework is indexing broadcast news from radio and TV as a combination of large vocabulary continuous speech recognition (LVCSR), natural language processing (NLP) and information retrieval (IR). For indexing, the documents are presented as vectors of word counts, whose dimensionality is rapidly reduced by random mapping (RM). The obtained vectors are projected into the latent semantic subspace determined by SVD, where the vectors are then smoothed by a self-organizing map (SOM). The smoothing by the closest document clusters is important here, because the documents are often short and have a high word error rate (WER). As the clusters in the semantic subspace reflect the news topics, the SOMs provide an easy way to visualize the index and query results and to explore the database. Test results are reported for TREC's spoken document retrieval databases (www.idiap.ch/kurimo/thisl.html).
Presence of anti-La autoantibody is associated with a lower risk of nephritis and seizures in lupus patients (2007)

Previous reports suggest a protective role for anti-La autoantibody against the development of lupus nephritis. We studied the effect of anti-La on the prevalence of nephritis in a large cohort of lupus patients. In addition, we determined the association between anti-La and the presence of the various other lupus manifestations. We studied 1100 lupus patients enrolled in the Lupus Family Registry and Repository. Only one lupus patient per family was selected to exclude intrafamilial correlation. Since anti-La is present in patients who also have anti-Ro autoantibody, we compared anti-Ro positive lupus patients in the presence or absence of anti-La. Clinical data were obtained from medical records, interviews and participant questionnaires. Tests for autoantibodies against extractable nuclear antigens were performed using immunodiffussion assays. There is no difference in the age, sex or race between the anti-La positive and anti-La negative lupus patients. The presence of anti-La is associated with a significant reduced risk of lupus nephritis (proteinuria: 29.3% versus 46.3%, OR = 0.48, P = 0.023; cellular casts: 8.6% versus 20.6%, OR = 0.36, P = 0.038). In addition, lupus patients with anti-La have a reduced risk for seizures (0% versus 10.9%, P = 0.0096) and are more likely to have arthritis (79.3% versus 64.0%, OR = 2.16, P = 0.031). The presence of anti-nRNP autoantibody is significantly reduced in anti-La positive compared with anti-La negative lupus patients (10.3% versus 27.4%, OR = 0.31, P = 0.0075). In conclusion, anti-La autoantibody is associated with less severe lupus. Patients with anti-La have a lower risk of renal involvement and seizures compared with anti-La negative lupus patients.