gebhart/patrepeval huggingface dataset:
Deep Learning Based on Generative Adversarial and Convolutional Neural Networks for Financial Time Series Predictions (2020)

In the big data era, deep learning and intelligent data mining technique solutions have been applied by researchers in various areas. Forecast and analysis of stock market data have represented an essential role in today's economy, and a significant challenge to the specialist since the market's tendencies are immensely complex, chaotic and are developed within a highly dynamic environment. There are numerous researches from multiple areas intending to take on that challenge, and Machine Learning approaches have been the focus of many of them. There are multiple models of Machine Learning algorithms been able to obtain competent outcomes doing that class of foresight. This paper proposes the implementation of a generative adversarial network (GAN), which is composed by a bi-directional Long short-term memory (LSTM) and convolutional neural network(CNN) referred as Bi-LSTM-CNN to generate synthetic data that agree with existing real financial data so the features of stocks with positive or negative trends can be retained to predict future trends of a stock. The novelty of this proposed solution that distinct from previous solutions is that this paper introduced the concept of a hybrid system (Bi-LSTM-CNN) rather than a sole LSTM model. It was collected data from multiple stock markets such as TSX, SHCOMP, KOSPI 200 and the S&amp;P 500, proposing an adaptative-hybrid system for trends prediction on stock market prices, and carried a comprehensive evaluation on several commonly utilized machine learning prototypes, and it is concluded that the proposed solution approach outperforms preceding models. Additionally, during the research stage from preceding works, gaps were found between investors and researchers who dedicated to the technical domain.
The human cytomegalovirus UL45 gene product is a late, virion-associated protein and influences virus growth at low multiplicities of infection (2003)

Human cytomegalovirus (HCMV) encodes a protein related to the large (R1) subunit of ribonucleotide reductase (RR), but does not encode the corresponding small (R2) subunit. The R1 homologue, UL45, lacks many catalytic residues, and its impact on deoxyribonucleotide (dNTP) production remains unknown. Here, UL45 is shown to accumulate at late stages of infection and to be a virion tegument protein. To study UL45 function in its genome context, UL45 was disrupted by transposon insertion. The UL45-knockout (UL45-KO) mutant exhibited a growth defect in fibroblasts at a low m.o.i. and also a cell-to-cell spread defect. This did not result from a reduced dNTP supply because dNTP pools were unchanged in resting cells infected with the mutant virus. Irrespective of UL45 expression, all cellular RR subunits - S-phase RR subunits, and the p53-dependent p53R2 - were induced by infection. p53R2 was targeted to the infected cell nucleus, suggesting that HCMV diverts a mechanism normally activated by DNA damage response. Cells infected with the UL45-KO mutant were moderately sensitized to Fas-induced apoptosis relative to those infected with the parental virus. Together with the report on the UL45-KO endotheliotropic HCMV mutant (Hahn et al., J Virol 76, 9551-9555, 2002), these data suggest that UL45 does not share the prominent antiapototic role attributed to the mouse cytomegalovirus homologue M45 (Brune et al., Science 291, 303-305, 2001).
Trunculins A and B, norsesterterpene cyclic peroxides from a marine sponge, Latrunculia brevis (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTrunculins A and B, norsesterterpene cyclic peroxides from a marine sponge, Latrunculia brevisRobert J. Capon, John K. MacLeod, and Anthony C. WillisCite this: J. Org. Chem. 1987, 52, 3, 339–342Publication Date (Print):February 1, 1987Publication History Published online1 May 2002Published inissue 1 February 1987https://pubs.acs.org/doi/10.1021/jo00379a004https://doi.org/10.1021/jo00379a004research-articleACS PublicationsRequest reuse permissionsArticle Views209Altmetric-Citations49LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Susceptibility genes and B‐chronic lymphocytic leukaemia (2007)

Common genetic variants are thought to increase the risk of chronic lymphocytic leukaemia (CLL), and case-control studies provide an approach to detect these variants. There have been multiple candidate gene studies published to date, but relatively few disease pathway studies or large genomic association studies. We summarize the results of these previous studies, as well as present results from our recent large pathway study of 9412 single nucleotide polymorphisms from 1253 immunity and inflammation genes in a study of 126 CLL cases and 484 frequency-matched controls. Several promising genes have been identified as susceptibility genes for risk of CLL across all of these association studies. However, a number of candidate gene studies have not been replicated in follow-up studies, whereas the results from disease pathway and large genomic studies have yet to be replicated in an independent sample. The challenge of future studies of this type will be overcoming study design issues, including definition of CLL, sample size limitations and multiple testing issues.
ChemInform Abstract: The Stereoselective Photochemical Addition of Alcohols to 5‐ Substituted Furan‐2(5H)‐ones. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Food Volume Estimation in a Mobile Phone Based Dietary Assessment System (2012)

There is now convincing evidence that poor diet, in combination with physical inactivity are key determinants of an individual's risk of developing chronic diseases, such as obesity, cancer, cardiovascular disease or diabetes. Assessing what people eat is fundamental to establishing the link between diet and disease. Food records are considered the best approach for assessing energy intake. However, this method requires literate and highly motivated subjects and adolescents and young adults are the least likely to undertake food records. The ready access of the majority of the population to mobile phones has opened up new opportunities for dietary assessment. In such systems, the camera in the mobile phone is used for capturing images of food consumed and these images are then processed to automatically estimate the nutritional content of the food. A vital step in this process is the estimation of the volume of the food in the image. In this paper we propose a food volume estimation approach which requires only a pair of stereo images to be captured. Our experimental results show that the proposed approach can provide an accurate estimate of the volume of typical food items in a passive manner without the need for manual fitting of 3D models to the food items.
Multiple multicenter reactions of perfluoro ketones with olefins (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMultiple multicenter reactions of perfluoro ketones with olefinsW. H. Urry, J. H. Y. Niu, and L. G. LundstedCite this: J. Org. Chem. 1968, 33, 6, 2302–2310Publication Date (Print):June 1, 1968Publication History Published online1 May 2002Published inissue 1 June 1968https://pubs.acs.org/doi/10.1021/jo01270a026https://doi.org/10.1021/jo01270a026research-articleACS PublicationsRequest reuse permissionsArticle Views190Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
MAP kinase phosphatase (Mkp)-1 Controls Program Death-Ligand (PD-L)1 Expression during Sepsis (2019)

Abstract Mkp-1 is a critical negative regulator of the inflammatory response, and plays a crucial role for bacterial clearance in an animal model of sepsis. Mkp-1−/− mice exhibit augmented inflammation, increased bacterial burden, elevated organ damage, and increase mortality relative to Mkp-1+/+ mice following E. coli infection. To understand the functions of Mkp-1, we performed RNA-seq with mouse livers. Under normal conditions, 357 genes were differentially expressed between Mkp-1+/+ and Mkp-1−/− mice. However, following E. coli infection &amp;gt; 5,400 genes displayed differential expression between the two groups. Among genes upregulated by E. coli infection and exacerbated by Mkp-1−/− are PD-L1 and CTLA-4, two key immune checkpoint proteins. Interestingly, the expression of PD-L1 and CTLA-4 were highly correlated with the expression of IL-6, IL-10, and STAT3. qRT-PCR and Western blot analyses verified E. coli infection-induced PD-L1 expression and further exacerbation in Mkp-1−/− mice. Examination of the RNA-seq dataset revealed a clear interferon signature. ELISA analyses on the serum revealed low IFN-β levels in uninfected Mkp-1+/+ and Mkp-1−/− mice, increased IFN-β levels in E. coli-infected Mkp-1+/+ mice, and further augmented IFN-β levels in E. coli-infected Mkp-1−/− mice. Similarly, Mkp-1−/− bone marrow-derived macrophages also produced more IFN-β following stimulation with either LPS or heat-killed E. coli than Mkp-1+/+ macrophages. Our studies indicate that expression of immune check point proteins, PD-L1 and CTLA-4, are controlled by Mkp-1 during microbial infection. Our studies also suggest that exaggerated expression of type I interferons and PD-L1 contribute to the phenotypes of Mkp-1−/− mice in the model of sepsis.
Modification of the Association between PM 10 and Lung Function Decline by Cadherin 13 Polymorphisms in the SAPALDIA Cohort: A Genome-Wide Interaction Analysis (2014)

CDH13 is functionally linked to the adipokine adiponectin, an inflammatory regulator. Future studies need to confirm the interaction and assess how the result relates to previously observed interactions between air pollution and obesity on respiratory function.
Microwave Plasma Synthesis of Materials—From Physics and Chemistry to Nanoparticles: A Materials Scientist’s Viewpoint (2014)

In this review, microwave plasma gas-phase synthesis of inorganic materials and material groups is discussed from the application-oriented perspective of a materials scientist: why and how microwave plasmas are applied for the synthesis of materials? First, key players in this research field will be identified, and a brief overview on publication history on this topic is given. The fundamental basics, necessary to understand the processes ongoing in particle synthesis—one of the main applications of microwave plasma processes—and the influence of the relevant experimental parameters on the resulting particles and their properties will be addressed. The benefit of using microwave plasma instead of conventional gas phase processes with respect to chemical reactivity and crystallite nucleation will be reviewed. The criteria, how to choose an appropriate precursor to synthesize a specific material with an intended application is discussed. A tabular overview on all type of materials synthesized in microwave plasmas and other plasma methods will be given, including relevant citations. Finally, property examples of three groups of nanomaterials synthesized with microwave plasma methods, bare Fe2O3 nanoparticles, different core/shell ceramic/organic shell nanoparticles, and Sn-based nanocomposites, will be described exemplarily, comprising perspectives of applications.
Intravenous ganciclovir prophylaxis for cytomegalovirus in heart, heart-lung, and lung transplant recipients (1999)

Cytomegalovirus (CMV) disease has had a significant clinical impact on the heart, heart-lung and lung transplant recipients in our centre. CMV disease has been so severe with CMV antibody-negative heart-lung transplant patients receiving organs from CMV antibody-positive donors (CMV-mismatched patients) that in 1986 we adopted the policy of not transplanting CMV-positive organs into CMV-negative heart-lung or lung recipients. In December 1992, we instituted a policy of providing intravenous ganciclovir (5 mg/kg twice a day for 28 days) during the immediate postoperative period for CMV-mismatched heart recipients and CMV antibody-positive heart-lung and lung patients, who have been the patients at greatest risk of severe CMV disease in our centre. A placebo group was not employed because of ethical considerations, ganciclovir having been shown to be effective for the treatment of CMV infections among transplant patients. Compared with a historical control group of patients receiving no prophylaxis, prophylactic ganciclovir reduced the incidence of CMV infection (39 % vs 91 %, P = 0.0006) and CMV disease (17 % vs 74 %, P = 0.0004) among CMV antibody-positive heart-lung recipients. Prophylactic ganciclovir did not significantly reduce the incidence of CMV infection or disease among heart or isolated lung recipients. Ganciclovir was well tolerated, with few adverse reactions. In the case of heart-lung transplant patients, one month of intravenous prophylactic ganciclovir significantly reduced the incidence of both CMV infection and disease when compared with patients who received no prophylaxis. With the lung transplant and heart transplant patients, there were no significant differences between the prophylaxis and nonprophylaxis groups, although there was a consistent trend towards less infection and disease in the prophylaxis groups.
Pupillary dilation elicited by attending to two disks with different luminance (2021)

Pupils become smaller when people attend to a bright disk as compared to a dark disk. However, people can divide their attention into several distinct positions, which is referred to as divided attention, and pupillary responses under such conditions have not been investigated. In this study, we examined how pupils would respond when people attended to two disks presented at two distinct positions by conducting three experiments. We found that the pupillary response when attending to two disks with different luminance was larger than when attending to a single brighter disk and was comparable to that when attending to a single darker disk, whereas the pupillary response when attending to two disks with identical luminance was not larger than when attending to a single disk (irrespective of the disk luminance). Furthermore, we found that the magnitude of pupillary dilation was determined by the magnitude of the luminance difference between two disks. These results make a useful contribution to the literature on human pupillary responses.
CLEAN: Cryogenic Link for Electric Aircraft Propulsion (2023)

We propose a thermally efficient and power-dense high-temperature superconducting (HTS) cable (CLEAN Cable) as well as a thermally efficient, mechanically rugged, and easily attachable/detachable cryogenic-to-ambient power link (CLEAN Connector). The bundled design enables high gravimetric power density and node-less tapping of power. The CLEAN Connector minimizes ambient heat leaking into the cryogenic environment by magnetically coupling the cryogenic section to the ambient counterpart via a high-frequency isolated DC/DC converter. The proposed high-frequency operation reduces the core size of the cryogenic/ambient transformer that provides electrical and thermal isolation while enabling quick connection. The proposed CLEAN technologies provide the following advantages - (1) Reduced heat load; (2) High gravimetric power density; (3) <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">N</i> –1 system redundancy; (4) Minimum ambient heat leak into the cryogenic system; (5) High vibration/mechanical stress tolerance; (6) Partial discharge (PD) free at high-altitudes; (7) Easy cryogenic and ambient system connection; (8) Inherent fault detection and isolation.
Reduction of Sympathetic Influences on Penile Erection by Phentolamine (1991)

The lumbosacral sympathetic trunks seem to play a major role in penile detumescence. In animal experiments an erection induced by cavernous nerve stimulation can be abolished by neurostimulation of the canine sympathetic trunks. This canine experiment was designed to study the possible reduction of the sympathetic effect by intravenous injection of phentolamine. The aborted erection by sympathetic trunks stimulation was partially antagonized by phentolamine. The arterial flow to the penis as well as the intracavernous pressure were elevated by this drug. As an expected side effect the systemic arterial blood pressure decreased by 4-14 cm H2O after phentolamine injection.
A novel voltage controlled crystal oscillator (VCXO) circuits (2009)

Reference signal source requires high quality (Q) factor resonating element, such as micro-machined or piezoelectric crystal that acts as an electro-mechanical resonating element in VCXO circuits. Apart from the apparent advantages of these electro-mechanical resonators they suffer from multi-mode resonance and cross talks. The selection and controlling of the desired mode is critical and challenging task when the spacing between modes is relatively small. The active mode-selection techniques reported in this paper minimizes the mode-jumping and phase noise for overtone mode VCXO, even those with relative low Q factor crystal. The measured phase noise for 290 MHz 3 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rd</sup> order overtone VCXO is typically -128 dBc/Hz at 1 kHz offset from the carrier, and to authors knowledge, this is the reasonably good phase noise performance for the inexpensive class of VCXOs so far reported.
El Programa Araucaria y la Red Iberoamericana de Reservas Marinas (2003)

Uno de los esfuerzos mas visibles y a largo plazo de la Cooperacion Espanola se desarrolla en el sector de medio ambiente. Este esfuerzo se ha venido desplegando hasta la actualidad en forma de proyectos y asistencias tecnicas, pero en el mundo actual de rapida expansion de las comunicaciones cada vez se impone con mayor claridad la necesidad de un trabajo en red para el intercambio de experiencias, tecnologias y conocimientos.
Clinical efficacy and safety of endoscopic ultrasound‐guided gallbladder drainage replacement of percutaneous drainage: A multicenter retrospective study (2018)

Where ongoing gallbladder drainage is required, conversion from PTGBD to EUS-GBD is a feasible, effective, and safe technique for patients who cannot undergo cholecystectomy.
Use of holography to investigate photochemical reactions (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUse of holography to investigate photochemical reactionsD. M. Burland, G. C. Bjorklund, and D. C. AlvarezCite this: J. Am. Chem. Soc. 1980, 102, 23, 7117–7119Publication Date (Print):November 5, 1980Publication History Published online1 May 2002Published inissue 5 November 1980https://pubs.acs.org/doi/10.1021/ja00543a046https://doi.org/10.1021/ja00543a046research-articleACS PublicationsRequest reuse permissionsArticle Views65Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Overexpression of cyclins D1 and E is frequent in bronchial preneoplasia and precedes squamous cell carcinoma development. (1999)

Increased protein expression of the G1 cyclins D1 and E is reported in invasive non-small cell lung carcinoma. However, during transformation of the bronchial epithelium, overexpression of these species occurs, and their relationship to aberrant expression of p53 and retinoblastoma (Rb) has not been described previously. To determine the expression of these cell cycle regulators during the development of invasive squamous cell carcinoma (SCC) of the lung, the immunohistochemical expression patterns in normal bronchial epithelium (n = 36), squamous metaplasia (SM; n = 28), and epithelial atypia (n = 34) were compared with that in low-grade dysplasia (LGD; n = 17), high-grade bronchial dysplasia (HGD; n = 30), and SCC (n = 36). Monoclonal anti-p53 Pab1801, polyclonal anti-cyclin D1 DCS6, monoclonal anti-cyclin E HE12, and monoclonal anti-Rb OP-66 antibodies were used. Cyclin D1 was not expressed in normal bronchial epithelium but was detected in 7% of SMs, 15% of atypias; 18% of LGDs, 47% of HGDs, and 42% of SCCs. Cyclin E was not detected in normal epithelium (n = 24), SM (n = 16), or LGD (n = 12), but it was found in 9% of atypias (2 of 22), 33% of HGDs (7 of 21), and 54% of SCCs (13 of 24). p53 was not expressed in normal epithelium, SM, and LGD, but it was overexpressed in 6% of atypias, 53% of HGDs, and 61% of SCCs. Abnormal Rb expression was found only in 2 of 36 cases of SCC. A total of 91% of HGDs and 92% of SCCs exhibited overexpression of at least one of the p53, cyclin D1, or cyclin E species. However, no link was observed between overexpression of p53 and the overexpressed G1 cyclins in preneoplastic lesions. Overexpression of cyclin D1, cyclin E, and p53 occurs frequently and independently in pulmonary SCC and is detected in lesions before the development of invasive carcinoma. In contrast, altered Rb expression is a late and infrequent event in squamous cell carcinogenesis.