gebhart/patrepeval huggingface dataset:
Venlafaxine augmentation with agomelatine in a patient with obsessive-compulsive disorder and suicidal behaviors (2014)

Obsessive-compulsive disorder is a chronic and disabling condition that often proves to be treatment resistant. Of the patients suffering from obsessive-compulsive disorder, 10%-27% may attempt suicide at least once in their life. We report the case of a patient who presented severe obsessive-compulsive disorder symptoms and attempted suicide ingesting 25 tablets of fluoxetine (20 mg). The patient was treated with venlafaxine and agomelatine and showed improvement of obsessive symptoms and suicidal ideation. Future studies are needed to investigate this treatment regime in large cohorts of obsessive-compulsive disorder patients with suicidal ideation.
Automated polarization characterization system (2005)

There has been significant recent interest in the optimization of polarimeter systems, especially those designed for the remote sensing of polarization imagery. These studies have been motivated by a desire to improve the signal-to-noise-ratio (SNR) and the performance of the polarimeter in the presence of systematic calibration errors. These studies have been largely theoretical, and have not presented much experimental evidence of the theoretical predictions. In this paper, we present the design of an automated polarization characterization system that we use to test the theoretical hypothesis about the optimization of polarimeters. We present results here for rotating retarder polarimeters, and verify that quarter waveplates are not the optimum retarders to use in the presence of error and noise. Our results agree with predictions, but we find that the relative balance between noise and error is delicate.
Strong reversible Fe 3+ -mediated bridging between dopa-containing protein films in water (2010)

Metal-containing polymer networks are widespread in biology, particularly for load-bearing exoskeletal biomaterials. Mytilus byssal cuticle is an especially interesting case containing moderate levels of Fe(3+) and cuticle protein-mussel foot protein-1 (mfp-1), which has a peculiar combination of high hardness and high extensibility. Mfp-1, containing 13 mol % of dopa (3, 4-dihydroxyphenylalanine) side-chains, is highly positively charged polyelectrolyte (pI approximately 10) and didn't show any cohesive tendencies in previous surface forces apparatus (SFA) studies. Here, we show that Fe(3+) ions can mediate unusually strong interactions between the positively charged proteins. Using an SFA, Fe(3+) was observed to impart robust bridging (W(ad) approximately 4.3 mJ/m(2)) between two noninteracting mfp-1 films in aqueous buffer approaching the ionic strength of seawater. The Fe(3+) bridging between the mfp-1-coated surfaces is fully reversible in water, increasing with contact time and iron concentration up to 10 microM; at 100 microM, Fe(3+) bridging adhesion is abolished. Bridging is apparently due to the formation of multivalent dopa-iron complexes. Similar Fe-mediated bridging (W(ad) approximately 5.7 mJ/m(2)) by a smaller recombinant dopa-containing analogue indicates that bridging is largely independent of molecular weight and posttranslational modifications other than dopa. The results suggest that dopa-metal interactions may provide an energetic new paradigm for engineering strong, self-healing interactions between polymers under water.
Enzymic measurement of urinary pyrophosphate with a centrifugal analyzer. (1982)

We describe a simple, rapid, and fully automated technique for measuring urinary pyrophosphates with a centrifugal analyzer (the ENI GEMSAEC). This technique depends on the enzymic magnesium-dependent reaction with UDPG pyrophosphorylase (UTP: alpha-D-glucose-1-phosphate uridylyl transferase, EC 2.7.7.9) and spectrophotometry of the NADPH formed in a combined system of phosphorylation and reduction. Many samples of urine can be analyzed quickly without pretreatment, with high sensitivity (1.3 mA/mumol of substrate) and good reproducibility. The mean within-run coefficient of variation for a 50 mumol/L pyrophosphate solution was 1.4%. We determined the optimum enzyme and magnesium concentrations necessary for use in a 4-min reaction. Because there is no inhibitory effect of chloride and phosphate ions, pyrophosphate can be measured directly in urine, without prior extraction. With this technique, the mean value (and SD) for urinary pyrophosphate excretion by 30 healthy subjects was 39.3 (SD 17.2) mumol/24 h.
Method for Locating the Vapor−Liquid Critical Point of Multicomponent Fluid Mixtures Using a Shear Mode Piezoelectric Sensor (2004)

A new approach to locating the critical point of fluid mixtures is reported, utilizing a shear mode piezoelectric sensor. This technique employs a single piece of quartz crystal that is installed at the bottom of a strongly stirred high-pressure vessel. The sensor response indicates whether liquid or gas is in contact with its surfaces. Thus, the sensor is able to identify vapor-liquid phase separation by registering a discontinuity in the impedance minimum of the sensor as a function of pressure. Two systems (methanol + CO2 and H2 + CO2) have been investigated using this method. The critical point data of the methanol + CO2 system were chosen to validate the approach against a wealth of literature data, and good agreement was obtained. The sensor behavior in the two-phase region, as well as the effect of stirring, is discussed. The method is general and can be used with other sensors.
A new Robust &#x2018;Integral of Sign of Error&#x2019; feedback controller with adaptive compensation gain (2013)

In this paper, a new robust integral of signum of error (RISE) feedback type controller is designed for a class of uncertain nonlinear systems. Unlike the previous versions of RISE feedback type controllers, the proposed controller does not require prior knowledge of upper bounds of the vector containing the uncertainties of the dynamical system plus desired system dynamics (and their derivatives) for the control gain selection. The aforementioned enhancement is made possible via the design of a time-varying compensation gain as opposed to a constant gain used in previous RISE feedback type controllers. Asymptotic stability of the error signals and the boundedness of the closed-loop system signals are ensured via Lyapunov based arguments. Numerical simulation studies are presented to illustrate the viability of the proposed method.
The effect of sequence mismatches on binding affinity and endonuclease activity are decoupled throughout the Cas9 binding site (2017)

ABSTRACT The CRISPR-Cas9 system is a powerful genomic tool. Although targeted to complementary genomic sequences by a guide RNA (gRNA), Cas9 tolerates gRNA:DNA mismatches and cleaves off-target sites. How mismatches quantitatively affect Cas9 binding and cutting is not understood. Using SelexGLM to construct a comprehensive model for DNA-binding specificity, we observed that 13-bp of complementarity in the PAM-proximal DNA contributes to affinity. We then adapted Spec-seq and developed SEAM-seq to systematically compare the impact of gRNA:DNA mismatches on affinity and endonuclease activity, respectively. Though most often coupled, these simple and accessible experiments identified sometimes opposing effects for mismatches on DNA-binding and cutting. In the PAM-distal region mismatches decreased activity but not affinity, whereas in the PAM-proximal region some reduced-affinity mismatches enhanced activity. This mismatch-activation was particularly evident where the gRNA:DNA duplex bends. We developed integrative models from these measurements that estimate catalytic efficiency and can be used to predict off-target cleavage.
Field Trial of Cable Safety Protection and Road Traffic Monitoring over Operational 5G Transport Network with Fiber Sensing and On-Premise AI Technologies (2021)

We report the distributed-fiber-sensing field trial results over a 5G-transport-network. A standard communication fiber is used with real-time AI processing for cable self-protection, cable- cut threat assessment and road traffic monitoring in a long-term continuous test.
Transferable crosslinked chitosan membranes for human melanocyte culture (2011)

Development of transferable biocompatible membranes, which can be used for melanocyte culture and transplantation, is considered a feasible approach to increase the success rate for vitiliginous treatment. In this study, a crosslinked chitosan membrane (CCM) was produced via physical crosslinking of chitosan with sodium sulfate. The physical and mechanical properties as well as growth and phenotype expression of melanocytes on the CCM were investigated. The CCM supported growth and proliferation of melanocytes with the existence of melanin granules in the cytoplasm. The melanocytes remained active after transplantation. The CCM absorbed water approximately doubled from its original weight and permitted ∼2400 g/m² per day of water vapor transmission, suggesting that the CCM can function as an efficient wound dressing. Dynamic mechanical and tensile measurement results showed that the CCM possessed favorable wet strength for cell culture, separation, transfer, and transplantation application. This transferable CCM has the potential to be applied for vitiligo treatment.
ChemInform Abstract: [Cu(dap)2Cl] as an Efficient Visible‐Light‐Driven Photoredox Catalyst in Carbon—Carbon Bond‐Forming Reactions. (2012)

Abstract Title catalyst is successfully applied in atom‐transfer radical additions of alkyl halides towards olefins and allylation reactions of various nucleophiles, e.g. α‐haloketones and amines.
A Neural Network Approach for Milling Process Control (2004)

One of key approaches to improve the productivity is to control with constant force in the milling process by adjusting the feed rate. In order to overcome the mismatch model occurred in adaptive control and inaccurate deducing regulation in fuzzy logic control, a three-layer BP neural network is designed for tracing reference force. First of all, control arithmetic is given, and a series of simulation work is achieved to determine the study factor. At last, aimed at two working conditions with abrupt and gradual change of cutting depth, the correctness and effectiveness of the neural network controller are proved by experiments.
Nucleation-Controlled Polymerization of Nanoparticles into Supramolecular Structures (2013)

Controlled assembly of inorganic nanoparticles (NPs) into structurally defined supramolecular polymers will create nanomaterials with new collective properties. However, supramolecular polymerization of isotropic NPs remains a challenge because of the lack of anisotropic interactions in these monomers to undergo directional associations for the cooperative growth of supramolecular chains. Herein we report self-assembly behavior of poly(l-glutamic acid)-grafted gold NPs in solution and describe how combined attractive and repulsive interactions influence the shape and size of the resulting supramolecular assemblies. The study shows that the chain growth of supramolecular polymers can be achieved from the NP monomers and the process occurs in two distinct stages, with a slow nucleation step followed by a faster chain propagation step. The resulting supramolecular structures depend on both the grafting density of the poly(l-glutamic acid) on the NPs and the size of the NPs.
Molecular Modeling as a Visualization Tool in Design of DNA Crosslinked Polyacrylamide (2004)

Polymers such as polyacrylamide form a diverse class of biomaterials in use today. The experimental research performed by our group has demonstrated how a critical concentration of crosslinking DNA strands can lead to gel formation in the polyacrylamide. The removal or addition of DNA strands can reverse or significantly increase the stiffness and strength of the gel. DNA is a versatile material for the exploration of nanoscale structures because its hybridization chemistry is very specific. DNA crosslinked gels use end-modified DNA oligonucleotides in the gels. The ability to choose the base sequence in the DNA crosslinks offers an opportunity to engineer the nanoscale structure of this material. However, it is extremely difficult to visualize the sequence of events that occurs when DNA is crosslinked with polyacrylamide. Computer modeling is a tool that enables the researchers to study the structural aspects of the newly engineered DNA crosslinkers. In this study, polyacrylamide gel crosslinked with DNA has been assayed with respect to energy and size using AMBER 7.0 software [1]. Since DNA-crosslinked gels are likely to find a range of applications it is important to know how to tailor the gel composition for a particular application. It is also of interest to know what the composition is that would induce the greatest change in stiffness. The molecular models generated in AMBER survey the mechanical properties of the gel as a function of crosslinker density, polyacrylamide density, and crosslinker length. The structure of an equilibrium state is computed using an explicitly solvated model. Visual inspection of the model determines other mechanical properties of the gel and helps predict chemical interactions. A long-term goal of this work is to use computer assisted modeling techniques to guide the experiments, to predict linker stiffness, and to examine other mechanical properties of the DNA crosslinker.
Combined Effect of Reversible Flocculation and Ultrahigh Pressure in High-Level Deliquoring Attained by Expression of Activated Sludge (2014)

無機凝集剤のポリ塩化アルミニウム（PACl）と有機高分子凝集剤のクリフィックスを用いて，余剰活性汚泥の高度脱水を行った．脱水は，凝集スラリーの濾過，濾過ケークへの透水によるケーク内の凝集フロックの再分散化，超高圧圧搾の一連のプロセスから構成される．クリフィックスの使用は，PAClの場合に比べ濾過速度を著しく増加させたが，逆に圧搾速度は減少し，特に低圧搾圧力の場合に，その傾向は顕著であった．圧搾圧力の増加によるケーク含水率の低下は，クリフィックスよりPAClの場合の方がより顕著であった．注目すべきは，50 MPaの超高圧を作用させると，ケーク含水率は圧搾終了時に23.7 wt%まで減じたことである．Terzaghi型の一次圧密とそれに続く主に二段階のクリープ現象を考えることにより，平均圧密比や圧縮ケークの平均含水率の経時変化などの超高圧圧搾過程の動特性を良好に記述できた．その結果，クリフィックスの場合に，特に低い圧搾圧力においてクリープ効果が著しいことがわかった．また，修正圧密係数は圧搾圧力の増加とともに増大したが，ある限界圧搾圧以上では圧搾圧によらず一定値を示し，その値は，PACl，クリフィックスの場合にそれぞれ5, 10 MPa程度であった．
Electrochemistry coupled to Electrospray Mass Spectrometry for the study of the Oxidation of 4-Chloroaniline (2008)

Electrochemistry coupled to Electrospray Mass Spectrometry for the study of the Oxidation of 4-Chloroaniline
Synthesis of the three Cu-O layered Tl-(Pb,Bi)-Sr-Ca-Cu-O compound (1991)

A three Cu-O layered superconducting compound in the Tl-(Pb,Bi)-Sr-Ca-Cu-O system has been prepared by different processes. These include the use of excess Ca and Cu for off-stoichiometric composition, and the increase in Ca/Sr ratio for modified stoichiometric composition. A nearly single phase of 1223 superconductor can be obtained within three hours of heat treatment using the modified stoichiometric composition, whereas the intermediate phase (Ca,Sr)2CuO3 was remarkably accompanied in other synthetic processes. Observations were also corroborated by X-ray diffraction and magnetization measurements.
Disulfide Bonds in the Ectodomain of Anthrax Toxin Receptor 2 Are Required for the Receptor-Bound Protective-Antigen Pore to Function (2010)

We conclude that disulfide integrity within R2-Ig is essential for proper functioning of receptor-bound PA pore. This finding provides a novel venue to investigate the mechanism of anthrax toxin action and suggests new strategies for inhibiting toxin action.
오프라인의 실제적 자아와 SNS에서의 자아 간의 자아불일치에 영향을 미치는 선행요인과 결과요인 (2015)

SNS users generally desire to express their identity on SNS, and, recently, SNS is increasingly being used as a self-presentation tool. Regarding self-projection, SNS users tend to pay attention to other users' opinions or evaluations, and thus are likely to create a positive self-image on SNS. When...
Computational Analysis of Rho GTPase Cycling (2013)

The Rho family of GTPases control actin organization during diverse cellular responses (migration, cytokinesis and endocytosis). Although the primary members of this family (RhoA, Rac and Cdc42) have different downstream effects on actin remodeling, the basic mechanism involves targeting to the plasma membrane and activation by GTP binding. Our hypothesis is that the details of GTPase cycling between membrane and cytosol are key to the differential upstream regulation of these biochemical switches. Accordingly, we developed a modeling framework to analyze experimental data for these systems. This analysis can reveal details of GDI-mediated cycling and help distinguish between GDI-dependent and -independent mechanisms, including vesicle trafficking and direct association-dissociation of GTPase with membrane molecules. Analysis of experimental data for Rac membrane cycling reveals that the lower apparent affinity of GDI for RacGTP compared to RacGDP can be fully explained by the faster dissociation of the latter from the membrane. Non-dimensional steady-state solutions for membrane fraction of GTPase are presented in multidimensional charts. This methodology is then used to analyze glucose stimulated Rac cycling in pancreatic β-cells. The charts are used to illustrate the effects of GEFs/GAPs and regulated affinities between GTPases and membrane and/or GDI on the amount of membrane bound GTPase. In a similar fashion, the charts can be used as a guide in assessing how targeted modifications may compensate for altered GTPase-GDI balance in disease scenarios.
Regulation of protein phosphorylation and sodium transport in toad bladder. (1975)

It is well established that active sodium-ion transport and water flow across isolated toad bladder are increased by antidiuretic hormone (ADH) and by cAMP. These agents were also observed in previous studies to cause changes in the amount of radioactive phosphate in a specific protein in the toad bladder. This protein, found by SDS-polyacrylamide gel electrophoresis of toad bladder epithelial preparations, had an apparent molecular weight of 49,000 daltons. In the present study, a correlation was found between the ability of a variety of substances to affect the amount of radioactive phosphate in this 40,000-dalton protein and their ability to alter the rate of sodium transport. Thus several agents (ADH, cAMP, theophylline, adenine, prostaglandin E1, and Mn Cl-2) caused a decrease in the amount of radioactive phosphate in the 49,000-dalton protein and also stimulated active sodium transport across the bladder. Conversely, ZnCl-2 produced an increase in the amount of radioactive phosphate in this protein and an inhibition of sodium transport. With each of these agents, the time-course of change in phosphorylation of this protein was, in general, similar to that for sodium transport. A second phosphoprotein, with an apparent molecular weight of about 42,000 daltons, showed changes in parallel with, but less extensive than, those observed in the 49,000 dalton protein. There was no consistent relationship between changes in level of phosphorylation of either in the 49,000- or 42,000- dalton protein and changes in osmotic water permeability. The results are compatible with the possibility that regulation by ADH and by cAMP of sodium transport in the toad bladder epithelium may be mediated through regulation of the amount of phosphate in a specific protein.
Studies of Complement Complex C5b,6 Eluted from—EAC-6: Reaction of C5b,6 with EAC4b,3b and Evidence on the Role of C2a and C3b in the Activation of C5 (1974)

Abstract A macromolecular complex containing guinea pig complement fragment C5b (activated C5) and component C6 has been obtained from ĒĀC̄1̄,4̄b̄,2̄ā,3̄b̄,5̄b̄,6̄ (sheep erythrocytes carrying antibody and complement components, or fragments, C1, C4b, C2a, C3b, C5b and C6) or from ĒĀC̄4̄b̄,2̄ā,3̄b̄,5̄b̄,6̄ by elution. This complex combines with EAC4b,3b to yield an intermediate termed pseudo-EAC-6, which can be lysed by C7, C8 and C9, like genuine EAC-6, but which differs from the latter since it lacks C2a. In contrast, native C5 and C6 will produce EAC-6 only on reaction with ĒĀC̄4̄b̄,2̄ā,3̄b̄. Thus, cell-bound C2a is required for the reaction with native C5 but is not needed when C5 is supplied in the activated and complexed state C5b,6. Further, anti-C3 blocks the reaction of EAC4b,3b with C5b,6. These results suggest that in the reaction with native C5 the cell-bound C2a mediates the enzymatic activation of C5, whereas the cell-bound C3b supplies a binding site. In addition, the present experiments show that the activated state of C5b is stabilized by complexing with C6.
WEB-DL Endovascular Treatment of Wide-Neck Bifurcation Aneurysms: Short- and Midterm Results in a European Study (2014)

The results suggest that the WEB endovascular treatment of wide-neck bifurcation aneurysms offers stable occlusion in a class of aneurysms that are historically unstable. Additionally, our data show that opacification of the WEB recess can be delineated from true neck or aneurysm remnants.
RESTLESS LEGS (1946)

<h3>To the Editor:—</h3> In the January 5 issue of The Journal there were two communications concerning the syndrome of "restless legs," recently described by me (<i>Acta med. Scandinav.</i>, 1945, supp. 158). Dr. Hyman I. Goldstein writes that restless legs are similar to meralgia paresthetica and states that "perhaps Ekbom has only revived previously described syndromes." There is no need, however, to revive meralgia paresthetica. This syndrome is well known, and a description can be found in every textbook of neurology. The diagnosis is simple. It should not be possible to confuse it with restless legs. In meralgia paresthetica the discomfort is described as pins and needles, burning, numbness and even pain. It is felt superficially in a distinct area on the lateral aspect of one thigh, sometimes bilaterally. A certain amount of sensory loss is often found at examination. The paresthesia is aggravated by standing and walking. In restless legs
MW-3 Mini-Workshop: NanoTechnology and Information Technology for Space Applications (2006)

Start of the above-titled section of the conference proceedings record.
Focal surfaces of offset dual-reflector antennas (1982)

An analytical technique is described for finding the best focal surfaces for offset-fed dual-reflector antennas. A ray tracing procedure traces the loci of rays incident on the main reflector onto a plane or ‘screen’ situated perpendicular to a central ray of the antenna system. Given, then, by computer graphics, the best feed locations for azimuth and elevation plane patterns, an aperture diffraction method is used which can compute the sidelobe levels and beamwidths resulting from aperture phase errors on scanned or multi-beam patterns. High-magnification Cassegrain or Gregorian antennas, with tilt angles optimised according to Japanese criteria, produce excellent radiation diagrams many beamwidths from the central, unaberrated pattern direction.
Pancreatitis Induced by Intravenous Infusion of a Fat Emulsion in an Alcoholic Patient (1984)

We report an alcoholic patient with acute relapsing pancreatitis in whom the intravenous infusion of a fat emulsion precipitated a bout of acute pancreatitis. The various relationships between pancreatitis, alcoholism, and hyperlipemia are not clear, and guidelines for the use of intravenous fat emulsions in patients with pancreatitis should take into account their complex interrelationship.