gebhart/patrepeval huggingface dataset:
Contrasting Effects of TGF‐β1 and TNF‐α on the Development of Dendritic Cells from Progenitors in Mouse Bone Marrow (1997)

Dendritic cells (DC) are a distinct population of leukocytes and specialized antigen-presenting cells for T cell responses. Prior work has shown that GM-CSF can induce the development of large numbers of DC from proliferating progenitors in mouse bone marrow. We have monitored the effects of potentially enhancing and suppressive cytokines in these cultures. In this system, many immature DC develop from proliferating precursors during the first six days of culture, and between days 6-8 maturation of typical nonadherent and nonreplicating DC takes place. The maturation is accompanied by a large increase in the expression of major histocompatibilities complex class II (MHC II) and B7-2/CD86, and in mixed leukocyte reaction stimulating activity. Tumor necrosis factor-alpha (TNF-alpha), previously shown to be required for development of human DC, was found to enhance the maturation of mouse DC in the last two days of culture. Transforming growth factor-beta 1 (TGF-beta 1), on the other hand, almost totally blocked DC maturation, but it had to be given in the first six days of culture when the DC were actively proliferating. TGF-beta 1 did not block the production of immature, MHC II-positive but B7-2/CD86-negative DC. Maturation would take place between days 6-8 as long as the cultures were depleted of Fc-receptor-bearing cells, or if TNF-alpha were added. In both instances, maturation was not blocked even when TGF-beta 1 remained in the culture. We conclude that the development of DC, in response to GM-CSF, can be modified by other cytokines. TGF-beta 1 is suppressive but only indirectly via Fc-receptor-bearing suppressive cells, presumably suppressive macrophages, while TNF-alpha enhances the final maturation of DC.
Evaluating the Effects of Weather Conditions on the Performance of Structural Fumigation in a Flour Mill Using Computational Fluid Dynamics Simulations (2007)

Validated Computational Fluid Dynamics (CFD) models of structural fumigation were used to perform eleven fumigation simulations under weather conditions of the same time period of different years (1996 2006). Although the simulated fumigations were performed for the same time period, year-to-year variations in weather conditions caused significantly different half-loss time (HLT) predictions. The average wind speeds and ambient temperature varied between 1.5 and 5.1 m/s and 16.2 and 29.1 C, respectively. In extreme cases, the HLT prediction can be more than 100% different (from 10.7 to 23.3 hours), yielding a difference in the achieved Ct products by more than 70% (from 476 to 840 g-hr/m3). These results implied that fumigators should quantify the effectiveness of temporary structural sealing in order to maximize HLT before a fumigation.
Human Centromere Protein C (CENP-C) Is a DNA-Binding Protein Which Possesses a Novel DNA-Binding Motif1 (1994)

Mammalian centromere proteins (CENPs) can be divided into those that translocate from centromere to midzone in the progress of mitosis, and those that remain at the centromere throughout the cell cycle. The latter including CENP-A, CENP-B, and CENP-C is the candidate for DNA-binding protein. CENP-B has been shown previously to possess the specific DNA-binding activity to 17-base pair sequences dispersed on human centromeric alphoid repeats. In this study, we examined DNA-binding property of CENP-C that is localized to inner kinetochore plate of the metaphase chromosome. We independently isolated a full-length cDNA encoding human CENP-C and expressed it as the polypeptide tagged with histidine oligomer in Escherichia coli. After affinity purification with Ni(2+)-chelated resin, DNA-binding activity of the recombinant CENP-C renatured on the membrane was demonstrated by using human genomic DNA and an alphoid subfamily in South-Western-type blotting analysis. By constructing a series of truncated products, the DNA-binding domain was located at an internal 101-amino-acid stretch with no apparent homology to any other DNA-binding proteins. This may suggest that CENP-C is directly involved in formation of kinetochore chromatin fibers.
Raman spectroscopic studies of silicate and related glass structure : a review (1983)

La spectrométrie Raman a été largement utilisée afin d'étudier la structure moléculaire des verres silicatés. Une grande partie de ces travaux ont eu pour but d'élaborer des modèles structuraux susceptibles d'être appliqués aux liquides silicatés à intérêt géologique. Cet article procède au recensement de ces études afin de faciliter l'accès à la littérature pertinente, et présente quelques travaux des auteurs non publiés à ce jour. Les interprétations des diverses études sont commentées, et les modèles qui en résultent pour les structures des verres et liquides silicatés sont considérés afin de faire ressortir les domaines d'accord général, et ceux qui, sujet à controverse, nécessitent une étude approfondie.
Neuronal circuits overcome imbalance in excitation and inhibition by adjusting connection numbers (2021)

The interplay between excitation and inhibition is crucial for neuronal circuitry in the brain. Inhibitory cell fractions in the neocortex and hippocampus are typically maintained at 15 to 30%, which is assumed to be important for stable dynamics. We have studied systematically the role of precisely controlled excitatory/inhibitory (E/I) cellular ratios on network activity using mice hippocampal cultures. Surprisingly, networks with varying E/I ratios maintain stable bursting dynamics. Interburst intervals remain constant for most ratios, except in the extremes of 0 to 10% and 90 to 100% inhibitory cells. Single-cell recordings and modeling suggest that networks adapt to chronic alterations of E/I compositions by balancing E/I connectivity. Gradual blockade of inhibition substantiates the agreement between the model and experiment and defines its limits. Combining measurements of population and single-cell activity with theoretical modeling, we provide a clearer picture of how E/I balance is preserved and where it fails in living neuronal networks.
Abstract 225: Parallel and Divergent Patterns of Gene Expression in Human Arteriovenous Fistula Maturation and Stenosis (2015)

Background: The biologic mechanisms that differentiate successful arteriovenous fistula (AVF) maturation from stenosis are not well understood. The brachiobasilic transposition offers an opportunity for studying the vascular remodeling process. This procedure is a two stage process: first to create a brachiobasilic AVF and second, to transpose the AVF near the skin in a delayed fashion, allowing the opportunity to harvest naïve vein, mature and stenotic AVF tissue. Identifying the molecular differences with regards to success (maturation) or failure (stenosis) are vital both for dialysis access care and as a model of vein remodeling on exposure to arterial flow. We hypothesize that basilic vein transposition (BVT) can be utilized as a unique means with which to study the biologic factors that affect stenosis and maturation. Methods/Results: Vein tissue was obtained at the time of initial access creation as naïve segments and again at the time of basilic vein transposition (following venous “arterialization”), resulting in a cohort of patient-matched naïve, mature, and stenotic segments. Time between procedures ranged from 3-8 months, with a mean of 5. Vein segments were scored at time of collection as mature or stenotic, and confirmed by histology. Real-time PCR was performed on extracted RNA using a panel of genes implicated in the process and regulation of both successful and “unsuccessful” vascular wall remodeling. Heme oxygenase-1, matrix metalloproteinase-9 (MMP9) and osteopontin (SPP1) are significantly upregulated in both mature and stenotic vein segments (vs. naïve); MMP9 and SPP1 were also significantly upregulated in mature vs. stenotic tissue. SPP1 was exclusively expressed in the medial region of mature and stenotic AVF. Stenotic samples demonstrated a significant increase in the expression of tissue inhibitor of metalloproteinase-1 (MMP-1) and endothelin-1 (EDN-1) versus both naïve and mature samples. Conclusion: The BVT offers a unique opportunity to identify potential mechanisms involved in AVF maturation and stenosis. There appears to be overlap in gene expression profiles for both mature and stenotic samples, however MMP-1 and EDN-1 appear to be significantly increased in venous stenosis.
Late onset hypogonadism in type 2 diabetic and nondiabetic male: a comparative study. (2012)

Sexual dysfunction in diabetic men can result from a variety of causes of which late onset hypogonadism is now a recognised entity. The study described here was conducted to determine this entity by comparing diabetic men with age matched controls. A significant number of diabetic men had low levels of testosterone and free testosterone. Among the patients with low testosterone a large percentage had low pituitary gonadotrophic hormones signifying that the disorder was actually hypogonadotrophic hypogonadism. This finding was then correlated with various risk factors present in the diabetic patients and positive correlations were found for many parameters.
The discreet charm of protein binding sites hardcover (2016)

I think I met Joseph Yariv sometime around 1987, during the 10 years I spent in York, UK, at the time that he, John Helliwell and I were collaborating on the solution of the concanavalin A mannosid...
Fas/APO-1 promoter polymorphism is not associated with non-melanoma skin cancer. (2001)

NMSC[3][1] incidence is increasing at an alarming rate [(1)][2] , and the majority of NMSC is likely attributable to UV exposure. An important biological effector of UV exposure is the Fas receptor, which in cooperation with Fas ligand induces apoptosis in keratinocytes after UV exposure [(2)][3] .
Coding Algorithms and VLSI Implementations for Digital TV and HDTV Satellite Broadcasting (1993)

Abstract Source coding techniques for reducing the bit rates of TV and HDTV signals are presented and discussed with respect to satellite broadcasting applications. The source coding techniques require transmission bit rates of 9 Mbit/s for a TV and 45 Mbit/s for an HDTV signal in order to provide distribution quality as required for broadcasting. Also three scalable coding schemes are outlined which allow graceful degradations at the boundary of the broadcasting service area by a transition from a HDTV to TV picture resolution. VLSI implementations of TV and HDTV decoders have been investigated in order to achieve compact and low cost realization. It is shown that the silicon area of VLSI devices can be kept small by choosing algorithms with small signal processing requirements and by taking advantage of a priori known features. VLSI architectures for the implementation of subband filters and DCT are discussed as key components.
Optimizing Analysis, Visualization, and Navigation of Large Image Data Sets: One 5000-Section CT Scan Can Ruin Your Whole Day (2011)

http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.11091276/-/DC1.
The Evolution of Historical Linguistics: Sir Ralph Turner Memorial Lecture 9th May, 1985 (1986)

It would, of course, be possible in the case of a man such as Sir Ralph Turner to devote an entire lecture to an extended obituary. Several full obituaries have already been published, but a brief notice of some salient features of his life and career are still, perhaps, in place in a Memorial Lecture in his honour. Ralph Lilley Turner was born in 1888 and educated at The Perse School, Cambridge, and at Christ's College, Cambridge. He entered the Indian Education Service and during the First World War he served with the Gurkha Rifles. After the war he was Professor of Indian Linguistics at Benares University, until he was appointed to the Chair of Sanskrit in London. In 1937 he became Director of the School of Oriental Studies, soon to become the School of Oriental and African Studies, until 1957. He was knighted in 1950, and from 1957 he spent an active retirement working almost until his death in 1983 on the final stages of the supplements to his life's work, the Comparative Dictionary of the Indo-Aryan Languages .
Impregnation of Curcumin into a Biodegradable (Poly-lactic-co-glycolic acid, PLGA) Support, to Transfer Its Well Known In Vitro Effect to an In Vivo Prostate Cancer Model (2019)

Prostate cancer (PCa) is one of the most common cancers in older men and is associated with high mortality. Despite advances in screening for early detection of PCa, a large proportion of patients continue to be diagnosed with metastatic disease, with ~20% of men showing a high tumor grade and stage. Medicinal plant extracts have a great potential to prevent/treat PCa, as well as to reduce its incidence/prevalence and improve survival rates. One of the most promising extracts is curcumin, which is a major, nontoxic, bioactive compound of <i>Curcuma longa</i>. Curcumin has strong antitumor activity <i>in vitro</i>. However, its potential beneficial in vivo affects are limited by its low intestinal absorption and rapid metabolism. In this study, curcumin was impregnated into a biodegradable poly(lactic-co-glycolic) acid (PLGA) support and characterized by FTIR and DSC, and its release by UV spectrophotometry. PLGA-curcumin was tested in different subcutaneous PCa xenograft models (PC3, 22rv1, and DU145 PCa cell-lines), and its effects evaluated by tumor progression an immuno-histochemical analysis (Trichromic, Ki67 and TUNEL stainings), were compared with those of a commercial curcumin preparation. Our results indicate that curcumin-impregnated PLGA is significantly more active (~2-fold increase) with respect to oral curcumin, which supports its use for subcutaneous administration.
Update on Vattenfall’s 30 MWth oxyfuel pilot plant in Schwarze Pumpe (2009)

Vattenfall is presently taking an experimental large-scale pilot test facility into operation for the detailed investigation of the oxyfuel firing process. The plant is located southeast of Berlin in Germany in the vicinity of the existing lignite-fired power plant Schwarze Pumpe. The oxyfuel pilot plant consists of a single 30MWth, top-mounted, PF burner and the subsequent flue gas cleaning equipment, electrostatic precipitator, wet flue gas desulpherization and the flue gas condenser. In addition to these components, a CO2 separation plant is placed downstream of the flue gas condenser to produce liquid CO2. A cryogenic air separation unit located at the site will supply gaseous oxygen with a minimum purity of 99,5% needed for the combustion. The burner is designed for both pre-dried lignite and bituminous coal which will be tested in a later phase. The construction started in January 2007 and the first major test phase is planned to start in November 2008. The liquid CO2 is planned to be used for test injections to qualify the Altmark gas field in Germany as a storage site for CO2 for up-coming carbon capture and storage projects and to investigate opportunities for enhanced gas recovery. This paper will present some background information and describe the planned measurements. Initial experiences from the commissioning of the pilot plant will be presented.
Dissemination of bla KPC-2 by the Spread of Klebsiella pneumoniae Clonal Complex 258 Clones (ST258, ST11, ST437) and Plasmids (IncFII, IncN, IncL/M) among Enterobacteriaceae Species in Brazil (2011)

This article reports the spread of bla(KPC-2) in the Sao Paulo and Rio de Janeiro states, facilitated by globally spread K. pneumoniae clonal complex 258 (CC258) clones (ST258, ST11, and ST437) and a diversity of plasmids (IncFII, IncN, and IncL/M, two untypeable plasmids carrying Tn4401a or Tn4401b) successfully disseminated among species of the Enterobacteriaceae (Enterobacter cloacae, Serratia marcescens, and Citrobacter freundii). It also constitutes the first description of sequence type 258 (ST258) in Brazil, which was associated with a nosocomial hospital outbreak in Ribeirao Preto city.
The dependence of the input impedance on feed position of probe and microstrip line-fed patch antennas (2001)

The impedance of a rectangular patch antenna fed by an inset microstrip transmission line was measured for various feed positions. The dependence found was then compared to theoretical predictions both for this geometry and for the similar case of an inset coaxial probe feed.
Mechanism of the reaction between cis-[PtCl2(NH3)2] and DNA in vitro (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMechanism of the reaction between cis-[PtCl2(NH3)2] and DNA in vitroN. P. Johnson, A. M. Mazard, J. Escalier, and J. P. MacquetCite this: J. Am. Chem. Soc. 1985, 107, 22, 6376–6380Publication Date (Print):October 1, 1985Publication History Published online1 May 2002Published inissue 1 October 1985https://pubs.acs.org/doi/10.1021/ja00308a036https://doi.org/10.1021/ja00308a036research-articleACS PublicationsRequest reuse permissionsArticle Views219Altmetric-Citations59LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Image-Based Planning and Validation of C1-C2 Transarticular Screw Fixation Using Personalized Drill Guides (2002)

Objective: Posterior transarticular spine fusion is a surgical procedure used to stabilize the cervical bodies C1 and C2. Currently, spine screws are used most frequently, according to the procedure of Magerl. As the anatomy is rather complex and the view is limited, this procedure has a high risk factor. We present and validate a planning system for cervical screw insertion based on preoperative CT imaging.Materials and Methods: The planning system discussed allowed a neurosurgeon to interactively determine the desired position of the cervical screws, based on appropriate and real-time reslices through the preoperative CT image volume. From the planning, a personalized mechanical drill guide was derived as a means of transferring the plan intraoperatively. Eight cadaver experiments were performed to validate this approach. Postoperative CT was applied, and screw locations were extracted from the postoperative images after registering them to preoperative images. In this way, the deviations of the axes of the planned and inserted screws were determined.Results: From an initial cadaver series, it was observed that the drill guides were not stable enough to cope with the drilling forces, and tended to become displaced. Still, most of the inserted screws were reported to be placed adequately. No vascular compromise or invasion of the spinal canal was observed. For a second cadaver series, the design of the drill guide was altered. In this series, the displacement was no longer present, and all screws were optimally placed.Conclusions: The preoperative planning system allowed the neurosurgeon to rehearse screw insertion in a way that is closer to surgical reality. The image-based validation technique allowed verification and enhancement of the template design on a cadaver study, giving accuracies comparable to those obtained with transfer by navigation.
Exploiting prior information in GraphSLAM (2011)

In this paper we present a general method for exploiting prior information to constrain the location of land marks in GraphSLAM. Prior information can be obtained for many environments in many different ways. However, this information can be incomplete, out-of-date, or presented in a different form than that used by the robot. Therefore, we argue that prior information is most naturally modelled as sets of potential constraints that act between landmarks. We present an extension of GraphSLAM that incorporates these constraints. We illustrate the results in an experiment with a 3D laser scanner and demonstrate a significant improvement in performance.
ChemInform Abstract: Reactions of Sulfur Monochloride with Some Aromatic Aldehyde Semicarbazones and Thiosemicarbazones: New Syntheses of Substituted 2,4‐Dihydro‐ 1,2,4‐triazol‐3‐ones, 2,4‐Dihydro‐1,2,4‐triazole‐3‐thiones and 2‐Amino‐ 1,3,4‐oxadiazoles. (1987)

Abstract The semicarbazones (I) are cyclized on treatment with disulfur dichloride (II) to give the triazolones (III).
ChemInform Abstract: 3‐ALKOXY‐2‐OXANORCARANES, SYNTHESIS OF LABILE CYCLOPROPANES FROM LABILE OLEFINS USING AN IMPROVED LITHIUM‐AMMONIA REDUCTION PROCEDURE ON THE DICHLOROCARBENE ADDUCTS (1975)

Abstract Mit Trichloressigester (II) erhält man aus den Dihydropyranen (I) in Gegenwart von Alkoholat die Addukte (III) in Form ihrer Stereoisomeren.
Digital Compensation Scheme for Coefficient Errors of Complex Filter Bank Parallel A/D Converter in Low-IF Receivers (2002)

A digital compensation scheme for coefficient errors of a complex filter bank in low-IF receivers is presented. The complex filter bank is employed to suppress DC offset and image signals in the low-IF receivers and relax the requirements on the conversion rate and resolution of A/D converters. The proposed compensation scheme regenerates interference due to the coefficient errors and subtracts it from the digital signal converted by an A/D converter. The proposed scheme also improves the effective resolution of A/D converters.