gebhart/patrepeval huggingface dataset:
PROXIES OF FRAILTY AND INFLAMMATION PREDICT ALTERED WHITE MATTER MICROSTRUCTURE IN OLDER ADULTS (2022)

Abstract Age-related elevations in inflammation are associated with both neurodegeneration and increased frailty in older adults. Here we used state-of-the-art diffusion-MRI (dMRI) methods to examine how specific markers of white matter (WM), including fiber density [FD], fiber cross-section [FC], and extracellular cerebral spinal fluid [CSF] are linked to inflammation and frailty in a population-based aging cohort. We hypothesized that increased inflammation and frailty would be associated with reduced FD and FC and increased CSF. Participants included 255 older adults (Mage=70.46; SD=3.79 years; 42% women) recruited from the Berlin Aging Study-II (BASE-II) for MRI scanning. Measures of blood serum ferritin and grip strength (corrected for sex and body mass) served as proxies of inflammation and frailty, respectively. Processing of dMRI data (b=1000 s/mm2; 60-directions) followed the MRtrix3 fixel-based analysis (FBA) pipeline, extended for voxelwise estimation of FD, FC, and CSF, with data transformed to a sample-specific template. The voxelwise estimates of FD, FC, and CSF were then regressed on the measures of blood serum ferritin and grip strength, correcting for multiple comparisons. Greater inflammation (ferritin) and frailty (grip strength) predicted lower FD in the internal capsule and anterior commissure. Higher ferritin also predicted lower FC in dorsal cingulum and forceps minor. Finally, frailty, but not inflammation, predicted increased CSF in multiple regions. These findings demonstrate common and specific associations of inflammation and frailty with WM in older adults and highlight the utility of newer methods for characterizing WM alterations.
Antiarrhythmic Hit to Lead Refinement in a Dish Using Patient-Derived iPSC Cardiomyocytes (2021)

Ventricular cardiac arrhythmia (VA) arises in acquired or congenital heart disease. Long QT syndrome type-3 (LQT3) is a congenital form of VA caused by cardiac sodium channel (I<sub>NaL</sub>) SCN5A mutations that prolongs cardiac action potential (AP) and enhances I<sub>NaL</sub> current. Mexiletine inhibits I<sub>NaL</sub> and shortens the QT interval in LQT3 patients. Above therapeutic doses, mexiletine prolongs the cardiac AP. We explored structure-activity relationships (SAR) for AP shortening and prolongation using dynamic medicinal chemistry and AP kinetics in human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). Using patient-derived LQT3 and healthy hiPSC-CMs, we resolved distinct SAR for AP shortening and prolongation effects in mexiletine analogues and synthesized new analogues with enhanced potency and selectivity for I<sub>NaL</sub>. This resulted in compounds with decreased AP prolongation effects, increased metabolic stability, increased I<sub>NaL</sub> selectivity, and decreased avidity for the potassium channel. This study highlights using hiPSC-CMs to guide medicinal chemistry and "drug development in a dish".
Structure-Activity Relationships of Protoberberines Having Antimicrobial Activity (1998)

13-Alkyl derivatives (2-6 and 8-12) of berberine (1) and palmatine (7) were subjected to in vitro antibacterial activity tests against Bacillus subtilis and Salmonella enteritidis. Antibacterial activity increased as the length of the C-13 aliphatic side chain increased. The effects of the oxygen-substituents on aromatic rings A, C, and D of protoberberinium salts 13-20 on the antimicrobial activity against Staphylococcus aureus, B. subtilis, S. enteritidis, Escherichia coli, and Candida albicans are also discussed. The change in lipophilicity of the protoberberinium salts caused by modification of the substituents appears to influence the antibacterial activity. 13-Hexylberberine (6) and 13-hexylpalmatine (12) exhibited the greatest antibacterial activity.
Modern Pulsed Power: Charlie Martin and Beyond (2004)

In this introduction to the Special Issue on pulsed power and its applications, background information is provided for the nonspecialist to better understand the many challenges in designing pulsed power systems, and the wide diversity of applications that are now emerging. The approach to providing a tutorial on pulsed power technology is to make available to the reader the paper written by J. C. Martin which appeared in a Special Section of the Proceedings of the IEEE on pulsed power technology in June 1992. That paper is supplemented in this introduction with additional information that complements many of the invited papers composing this Special Issue.
Bio‐Physicochemical Dual Energy Harvesting Fabrics for Self‐Sustainable Smart Electronic Suits (2023)

Abstract Despite the rapid development of various wearable generators to harvest energy from human activity, they are limited to single or intermittent power generation. Here, stretchable and washable energy harvesting fabric is reported, which enables biomechanical and biochemical generation through co‐weaving triboelectric generator (TEG) and perspiration electric generator (PEG)‐based fibers. The two energy harvesting approaches can work individually or simultaneously, thereby combating humidity and increasing the electrical output. The maximum output power density of TEG‐ and PEG‐based fibers can achieve 166 and 5.4 µW cm −2 , respectively. The woven‐structured patch‐type energy harvester is conformable with clothing. It can harvest energy from human movements and sweat to drive the wearable Internet of Things (IoT) without charging systems. This synergistic and complementary energy harvester can provide a viable standalone power source relying solely on human activity for wearable electronics.
Comparison of the Microstructure of Firm and Stem-End Softened Cucumber Pickles Preserved by Brine Fermentation (1985)

Soft and firm stem end tissues of cucumbers fermented at a low concentration of sodium chloride were examined by a combination of light microscopy {LM), transmission electron microscopy { TEM), and scanning electron microscopy { SEM) . When compared to firm tissue, softened tissue cell walls were swollen and striated, and the middle lamellae were poorly stained by the uranyl acetate-1 ead citrate used in TEM . When the tissue was penetrated by a circu l ar punch {1.5 mm diameter), cells in soft tissue tore along the middle l arne ll ae rather than across cell walls, as did cells in firm tissue. Thus, softening was characterized by a weakening of cell-to-cell junctions at the middle lamellae. Ultrastructural changes in the softened tissue were consistent with cellulolytic and / or pectinolytic degradation of cell wall components . Since fungal hyphae were found in both soft and firm tissue, it was not possible to determine if the softening was due to extracellular enzymes produced by invading organisms or to enzymes endogenous to the cucumber tissue.
ON MECHANICAL PROPERTIES OF REINFORCING STEEL IN RC BEAMS SUBJECTED TO HIGH TEMPERATURE (2011)

A b s t r a c t This paper considers the reinforcement elongation of RC elements subjected to fire in conformity with Eurocode (EN 1992-1-2). The stress-strain relationships for bars tensioned in elevated temperatures given in Eurocode, refer to 100 °C temperature intervals. These dependencies pertain to only a part of total reinforcement elongation – the part that occurs due to load action. The free steel thermal strain and creep elongations are not included. From the practical view point, when predicting the behaviour of RC elements once subjected to fire, it is important to estimate the total elongation of the rein forcement. It is the most convenient when these elongations are considered in correspondence with temperature, while the stress level is kept at constant. Such circumstances present the surroundings in which the reinforcement of structural ele ments is subjected during the real fire. In order to adequately predict the behaviour of heated reinforcement, free thermal strain should be added to the strain occurred due to load action. This paper presents appropriate relationships based on recommendations given in Eurocode, developed in the system of three coordinates: stress strain temperature. S t r e s z c z e n i e W artykule, bazując na wymaganiach Eurokodu (EN 1992-1-2), przeanalizowano odksztalcalnośc zbrojenia elementow zel betowych narazonych na dzialanie pozaru. Podane w Eurokodzie zalezności naprezenie odksztalcenie odnoszą sie do roz ciągania pretow w wysokich temperaturach, bedących wielokrotnością 100 °C. Zalezności te uwzgledniają jedynie cześc calkowitego odksztalcenia zbrojenia powstającą na skutek dzialania obciązenia. Swobodne odksztalcenia termiczne stali oraz odksztalcenia pelzania są natomiast pominiete. Z praktycznego punktu widzenia prognozowania zachowania sie ele mentow zelbetowych narazonych na dzialanie pozaru istotne jest oszacowanie calkowitych wydluzen ogrzewanego zbrojenia. Wydluzenia te najwygodniej jest rozpatrywac w zalezności od temperatury, przy ustalonych naprezeniach. W takich wlaśnie warunkach znajduje sie zbrojenie elementow podczas rzeczywistego pozaru. W celu adekwatnego przewidywania zachowa nia sie ogrzewanego zbrojenia, do odksztalcen pochodzących od obciązenia nalezy dodac swobodne odksztalcenia termiczne stali. W artykule przedstawiono stosowne zalezności opracowane w ukladzie trzech wspolrzednych naprezenie-odksztalce nie-temperatura, na bazie zalecen podanych w Eurokodzie.
Haruki Murakami, une littérature mondiale écrite en japonais : inerview sur l'oeuvre de Haruki Murakami (2014)

Haruki Murakami, une littrature mondiale crite en japonais En tte des ventes au Japon sa sortie en 2013, lanc Londres la manire d'Harry Potter en aot dernier, L'incolore Tsukuru Tazaki et ses annes de plerinages confirme le statut de star littraire de son auteur, l'ternel noblisable Haruki Murakami, docteur honoris causade l'ULg.Kanako Goto nous en parle.Jeune, Tsukuru Tazaki avait quatre amis insparables issus, comme lui, de la couche suprieure de la classe moyenne et dont les patronymes comprenaient chacun une couleur: Rouge et Bleu pour les garons, Blanche et Noire pour les filles.Il tait le seul incolore.Tous les quatre sont rests Nagoya, entrant dans des universits locales, tandis que Tsukuru est parti suivre des tudes Tokyo.Lui en ont-ils voulu?De retour dans sa ville natale pour les congs d't, il apprit, aprs avoir vainement tent de joindre ses anciens camarades, que ceux-ci ne voulaient plus le voir.Sans autres explications.Seize ans plus tard, encourag par son amie, celui qui, aprs avoir song la mort, est devenu un architecte spcialis dans le dessin des gares, va tenter de comprendre les raisons de ce rejet en les retrouvant les uns aprs les autres.
European Nb3Sn Superconducting Strand Production and Characterization for ITER TF Coil Conductor (2016)

The European Union contributes around 20% of the cable-in-conduit conductor lengths needed for the ITER toroidal field (TF) magnet coils. For that purpose, 97 tons of Nb <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> Sn superconducting strand have been fabricated over five years, the production being completed in 2014. This superconducting strand has been manufactured by two companies, namely, Bruker EAS (Germany) and OST (USA), through the bronze route and the internal tin diffusion, respectively. This paper reports the outcomes of this strand mass production and of the strand characterization as performed by the suppliers and cross-checked on a regular basis by Durham University.
Enhanced radical delivery from aldoxime esters for EPR and ring closure applications (2000)

Arylmethaniminyl and alkyl radicals were generated from di- and tri-methoxyphenyl aldoxime esters, by photolysis in the presence of 4-methoxyacetophenone, and were detected by EPR spectroscopy: good yields of cyclised products were isolated from suitably unsaturated alkyl substituents.
A RIO-like technique for interactivity loss-avoidance in fast-paced multiplayer online games (2005)

The astonishing increase in the spread of the Internet has given rise to a globally connected community proficient at deploying online games for a large number of participants geographically located very far from each other. However, online games are characterized by more stringent requirements than traditional distributed applications deployed over the Internet can fulfill. Indeed, one of the key factors in determining the success of an online game is its ability to rapidly deliver events to the various game servers that maintain the state of the game over the network. We have already demonstrated [Palazzi et al. 2004] that in this context adapting RED (random early detection) techniques, borrowed from queuing management, can improve the global responsiveness of a game. However, this solution may not be sufficient for a specific class of online games. We deem that fast-paced multiplayer online games (such as shoot 'em ups, for example) in which participants have to behave frenetically, must guarantee a very high degree of interactivity, even at the cost of partially sacrificing the consistency of the game state. In this case having only a partially consistent view of the game state will not affect a player's amusement as much as delaying action-processing activity will. Hence we explore the possibility of applying a RIO-based (RED with in and out) algorithm to manage game delivery to the various game servers, in order to improve the degree of interactivity for fast-paced online games. Preliminary experimental results confirm the viability of our approach.
Metal Containing Compounds: Precursors for new Reactions and Materials (1993)

The syntheses of six-membered metallacyclophosphazenes and metal containing siloxanes are described. Phosphazene and siloxane groups are isoelectronic a concept aiding in the synthesis of the target molecules. The metal containing silicones function as model compounds for metal oxides on silica surfaces. A first example of a metal containing borazine is given. Some of the compounds function as precursors for chemical vapor deposition.
A Gene Expression Signature that Can Predict Green Tea Exposure and Chemopreventive Efficacy of Lung Cancer in Mice (2006)

Green tea has been shown to be a potent chemopreventive agent against lung tumorigenesis in animal models. Previously, we found that treatment of A/J mice with either green tea (0.6% in water) or a defined green tea catechin extract (polyphenon E; 2.0 g/kg in diet) inhibited lung tumor tumorigenesis. Here, we described expression profiling of lung tissues derived from these studies to determine the gene expression signature that can predict the exposure and efficacy of green tea in mice. We first profiled global gene expressions in normal lungs versus lung tumors to determine genes which might be associated with the tumorigenic process (TUM genes). Gene expression in control tumors and green tea-treated tumors (either green tea or polyphenon E) were compared to determine those TUM genes whose expression levels in green tea-treated tumors returned to levels seen in normal lungs. We established a 17-gene expression profile specific for exposure to effective doses of either green tea or polyphenon E. This gene expression signature was altered both in normal lungs and lung adenomas when mice were exposed to green tea or polyphenon E. These experiments identified patterns of gene expressions that both offer clues for green tea's potential mechanisms of action and provide a molecular signature specific for green tea exposure.
Epididymal cysteine-rich secretory proteins are required for epididymal sperm maturation and optimal sperm function (2018)

This study was funded by the National Health and Medical Research Council, the Victorian Cancer Agency and a scholarship from the Chinese Scholarship Council. The authors have no conflicts of interest to declare.
Terapeuters brug af selvafsløring (2009)

Når terapeuten åbner for sin egen person over for klienten, kan det være en virksom intervention. Artiklen rummer teoretiske og praktiske refleksioner over self-disclosure og nondisclosure i psykoterapi og supervision<br/>
Early lactate clearance is associated with improved outcome in severe sepsis and septic shock* (2004)

Lactate clearance early in the hospital course may indicate a resolution of global tissue hypoxia and is associated with decreased mortality rate. Patients with higher lactate clearance after 6 hrs of emergency department intervention have improved outcome compared with those with lower lactate clearance.
Immobilization of microorganisms for detection by solid-phase immunoassays (1985)

Several cultures of gram-negative and gram-positive bacteria were successfully immobilized with titanous hydroxide. The immobilization efficiency for the microorganisms investigated in saline and broth media ranged from 80.2 to 99.9%. The immobilization of salmonellae was effective over a wide pH range. The presence of buffers, particularly phosphate buffer, drastically reduced the immobilization rate. However, buffers may be added to immunoassay systems after immobilization of microorganisms. The immobilization process involved only one step, i.e., shaking 100 microliter of culture with 50 microliter of titanous hydroxide suspension in polystyrene tubes for only 10 min. The immobilized cells were so tenaciously bound that vigorous agitation for 24 h did not result in cell dissociation. The nonspecific binding of 125I-labeled antibody from rabbits and 125I-labeled protein A by titanous hydroxide was inhibited in the presence of 2% gelatin and amounted to only 5.6 and 3.9%, respectively. We conclude that this immobilization procedure is a potentially powerful tool which could be utilized in solid-phase immunoassays concerned with the diagnosis of microorganisms.
Reconstruction of two bile ducts in a cloaca fashion in living donor liver transplantation. (2009)

The presence of two or more hepatic ducts for biliary anastomosis in adult-to-adult right liver transplantation is not uncommon. In the case described here, the graft had two hepatic ducts: one corresponded anatomically to a normal right hepatic duct and the other ran parallel to the proper hepatic duct and drained into its distal to the cystic duct. Because of the small diameter of both duct orifices and the favorable length of the ducts, a cloaca type reconstruction was performed. This allowed the construction of a single and larger orifice for the biliary anastomosis. In case of multiple hepatic ducts of smaller caliber, this technique represents a practical and effective hepatoplasty allowing a single larger anastomosis in the recipient.
Covalent Cross-Linking of Porous Poly(ionic liquid) Membrane via a Triazine Network (2016)

Porous poly(ionic liquid) membranes that were prepared via electrostatic cross-linking were subsequently covalently cross-linked via formation of a 1,3,5-triazine network. The additional covalent cross-links do not affect pore size and pore size distribution of the membranes and stabilize them toward salt solutions of high ionic strength, enabling the membranes to work in a broader environmental window.
Can bioenergy with carbon capture and storage result in carbon negative steel? (2020)

This paper explores the potential of achieving negative emissions in steelmaking by introducing bioenergy with carbon capture and storage (BECCS) in multiple steelmaking routes, including blast furnace and HIsarna smelt reduction, and Midrex and ULCORED direct reduction. Process modelling and life cycle assessment were used to estimate CO2 balances for 45 cases. Without bioenergy or CCS, the estimated life cycle CO2 emissions for steelmaking were 1.3–2.4 t CO2/t steel. In our model, aggressive BECCS deployment decreased net CO2 to the order of −0.5 t to 0.1 t CO2/t steel. CCS showed a larger mitigation potential than bioenergy, but combined deployment was most effective. As BECCS use increased, CO2 from background supply chains became more relevant. In the high BECCS cases, if decarbonized electricity is assumed, net CO2 estimates decreased by 400−600 kg CO2/t steel. Conversely, at 700 g CO2/kWh, all cases appeared to be net CO2-positive. Accounting for the “carbon debt” of biomass, beyond biomass supply chain emissions, increased net CO2 estimates by approximately 300 kg CO2eq/t steel. We conclude that CO2-negative steel is possible, but will require significant interventions throughout the production chain, including sustainable biomass cultivation; efficient steel production; CO2 capture throughout steel and bioenergy production; permanent storage of captured CO2; and rigorous monitoring.
Facile Amine Formation by Intermolecular Catalytic Amidation of Carbon−Hydrogen Bonds (2006)

A simple copper-based catalytic system has been developed for the carbon-hydrogen amidation reaction. The copper-homoscorpionate complex Tp(Br3)Cu(NCMe) catalyzes the transfer of the nitrene unit NTs (Ts = p-toluenesulfonyl) and its subsequent insertion into the sp(3) C-H bonds of alkyl aromatic and cyclic ethers or the sp(2) C-H bonds of benzene using PhI=NTs as the nitrene source, affording the corresponding trisubstitued NR(1)HTs amines in moderate to high yields. The use of the environmentally friendly chloramine-T has also proven effective, with the advantage that sodium chloride is formed as the only byproduct. A tandem, one-pot consecutive nitrene-carbene insertion system has been developed to yield amino acid derivatives.
MATERIALS FOR ENSURING HUMAN LIFE ACTIVITY AND ENVIRONMENT PROTECTION A Biomedical Cell Product for the Regeneration of Articular Cartilage: Biocompatible and Histomorphological Properties (an Experimental Model of Subcutaneous Implantation) (2015)

An in vivo study of the biological safety of a biomedical cell product for regeneration of articular cartilage with subcutaneous implantation of cellengi neered cartilage tissue was carried out. A comparative study of the biological safety of the cellengineered co nstruct of human articular cartilage tissue (CEC hAT) and the biocompatible BMCH matrix in an implantation test did not show significant differences between the control and experimental groups. The results demonstrated that the cell component of the cellengineered construct of hAT is not a risk factor for its implantation for up to 28 days. During the study, some signs of for� mation of articular tissue were observed at the site of subcutaneous implantation of the CEC hAT. Consider� ing high proliferation and differentiation activity of the CEC hAT previously confirmed after its cultivation for 42 days, it is possible to suggest the potential of using CEC hAT for regeneration of injured cartilage as an injection form of biomedical cell product.
The history of long-term oxygen therapy. (1983)

Early investigators of oxygen therapy reported an overall clinical improvement in persons with chronic lung disease who received oxygen. Later American and British studies showed that oxygen therapy could decrease pulmonary vascular pressures and red cell mass in some patients with pulmonary hypertension and polycythemia secondary to severe hypoxemia. The British Research Council Study showed that survival rates were significantly higher in patients receiving 15 hours of oxygen than in those receiving no oxygen. The Nocturnal Oxygen Therapy Trial showed that survival rates for persons receiving continuous oxygen therapy has also been shown to improve exercise tolerance and neuropsychiatric function. Further advances in the administration of long-term oxygen therapy and studies in the criteria for its use are needed.