gebhart/patrepeval huggingface dataset:
The molecular basis of chaperone-mediated interleukin 23 assembly control (2019)

The functionality of most secreted proteins depends on their assembly into a defined quaternary structure. Despite this, it remains unclear how cells discriminate unassembled proteins en route to the native state from misfolded ones that need to be degraded. Here we show how chaperones can regulate and control assembly of heterodimeric proteins, using interleukin 23 (IL-23) as a model. We find that the IL-23 α-subunit remains partially unstructured until assembly with its β-subunit occurs and identify a major site of incomplete folding. Incomplete folding is recognized by different chaperones along the secretory pathway, realizing reliable assembly control by sequential checkpoints. Structural optimization of the chaperone recognition site allows it to bypass quality control checkpoints and provides a secretion-competent IL-23α subunit, which can still form functional heterodimeric IL-23. Thus, locally-restricted incomplete folding within single-domain proteins can be used to regulate and control their assembly.
Preliminary Applications of the Variable Resolution Terrain Model to a Troop Movement Model. (1995)

Abstract : This report describes a methodology for simulating hastily planned cross-country movement. At the beginning of any military operation, one expects armies to move along routes determined by a thorough analysis of the terrain. However, as the operation progresses, local variations in the terrain may cause some of the troops to deviate from those preplanned routes, sometimes without much time to plan alternate routes. Our model simulates the local variations in troop movement on realistic terrain. The Variable Resolution Terrain (VRT) model was used to supply information about the terrain to the partial differential equation troop movement model. We also added functional overlays to the VRT model to describe environmental features such as bodies of water or foggy regions of the battlefield. By incorporating this information into our model, the simulated forces can avoid or react to environmental features while executing simple operational orders.
Web service access management for integration with agent systems (2008)

The agent paradigm includes the notion that agents interact with services. This paper identifies the need for controlled access to such services, from the perspective of agent systems (and not as is generally the case by web service providers). Mediating between web service requests from (virtual) organizations of agents, the web service gateway proposed regulates (i.e., monitors and controls) web service access according to the SLAs and organizational policies that are in effect. In addition to a model for web service access regulation, an implementation of a middleware component for web services access regulation based on SOAP and described in WSDL is presented.
Data Mining with Microsoft SQL Server 2000 Technical Reference (2001)

From the Publisher:
With its state-of-the-art capabilities for rapidly processing and retrieving huge quantities of data, Microsoft® SQL Server 2000 is quickly growing in popularity among large corporations. But learning how to take advantage of the powerful, built-in data-mining services in SQL Server to turn all that data into meaningful information takes time and effort. Data Mining with SQL Server 2000 Technical Reference is the ideal, in-depth reference guide for any database developer, administrator, or IT professional who needs comprehensive information about these powerful new data-mining services. In particular, it fully examines the data-warehousing architecture in SQL Server 2000 to show how to take full advantage of the data-mining services in this RDBMS. This is the only Microsoft-approved technical guide to the data mining services in SQL Server 2000.Positioning Statement: The ideal, in-depth reference for anyone who needs complete information about the powerful new data-mining tools and services in SQL Server 2000 Unique Selling Proposition: This title is the only Microsoft-approved technical guide to the data-mining services in SQL Server 2000.Key Book Benefits: Fully examines the data-warehousing architecture in SQL Server 2000 to show how to take full advantage of the data-mining services in this RDBMS Shows how the data-mining service in SQL Server fit into its complete suite of technologies for extracting meaningful information from data Is the only Microsoft-approved technical guide to the data-mining services in Microsoft SQL Server 2000
Defining hydrophobicity: probing the structure of solute-induced hydration shells by Fourier transform infrared spectroscopy (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDefining hydrophobicity: probing the structure of solute-induced hydration shells by Fourier transform infrared spectroscopyDavid Hecht, Lema Tadesse, and Lee WaltersCite this: J. Am. Chem. Soc. 1992, 114, 11, 4336–4339Publication Date (Print):May 1, 1992Publication History Published online1 May 2002Published inissue 1 May 1992https://doi.org/10.1021/ja00037a045RIGHTS & PERMISSIONSArticle Views137Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (548 KB) Get e-Alerts Get e-Alerts
Evaluation of Thrombopoiesis in Thrombocytopenic Disorders by Simultaneous Measurement of Reticulated Platelets of Whole Blood and Serum Thrombopoietin Concentrations (1998)

To evaluate thrombopoiesis in thrombocytopenic disorders, we simultaneously determined reticulated platelet counts in whole blood by FACScan flow cytometry and serum thrombopoietin (TPO) concentrations by a sensitive sandwich ELISA. The subjects were 40 healthy volunteers and 45 thrombocytopenic patients. In idiopathic thrombocytopenic purpura (ITP), the percentage of reticulated platelets was significantly elevated (5.61 +/- 2.02%: mean +/- SD) relative to normal controls (2.17 +/- 0.90%), but serum TPO concentrations (1.91 +/- 1.27 fmol/l) did not differ significantly from the normal range (1.43 +/- 0.62 fmol/l). The patients with aplastic anemia (AA) had decreased reticulated platelet counts and markedly increased serum TPO concentrations (13.65 +/- 10.64 fmol/l). In thrombocytopenic patients with liver cirrhosis (LC), the absolute number of reticulated platelets (1.65 +/- 1.11 x 10(9)/l) decreased similarly that in AA. However, serum TPO concentrations (1.38 +/- 0.50 fmol/l) did not increase in contrast to AA. Our findings suggested a possible dual mechanism of thrombocytopenia in LC; that is, thrombocytopenia in LC results from the decreased TPO production primarily in the liver adding to an increase in platelet sequestration in the spleen.
Exploring the Outer Solar System with Solar Sailing Smallsats on Fast-Transit Trajectories, In-Flight Autonomous Assembly of Advanced Science Payloads (2021)

We discuss the in-flight autonomous assembly as the means to build advanced planetary science payloads to explore the outer regions of the solar system. These payloads are robotically constructed from modular parts delivered by a group of smallsats (< 20 kg) which are placed on fast solar system transfer trajectories while being accelerated by solar sail propulsion to velocities of ~10 AU/yr. This concept provides the planetary science community with inexpensive, frequent access to distant regions of the solar system with flexible, reconfigurable instruments and systems that are assembled in flight. It permits faster revisit times, rapid replenishment and technology insertions, longer mission capability with lower costs. It also increases the science capabilities of smallsats via the use of modular, redundant architectures and allows for proliferation of sensing instrumentation throughout the solar system.
IGF‐1 receptor‐mediated ERK/MAPK signaling couples status epilepticus to progenitor cell proliferation in the subgranular layer of the dentate gyrus (2008)

Adult progenitor cell proliferation in the subgranular zone (SGZ) of the dentate gyrus is a dynamic process that is modulated by an array of physiological process, including locomotor activity and novel environmental stimuli. In addition, pathophysiological events, such as ischemia and status epilepticus (SE), have been shown to stimulate neurogenesis. Currently, limited information is available regarding the extracellular stimuli, receptors, and downstream intracellular effectors that couple excitotoxic stimulation to progenitor cell proliferation. Here we show that pilocarpine-induced SE triggers a set of signaling events that impinge upon the p42/44 mitogen-activated protein kinase (MAPK) pathway to drive progenitor cell proliferation in the SGZ at 2-days post-SE. Increased proliferation was dependent on insulin-like growth factor-1 (IGF-1), which was localized to activated microglia near the SGZ. Using a combination of techniques, we show that IGF-1 is a CREB-regulated gene and that SE triggered CRE-dependent transcription in microglia at 2-days post-SE. Together, these data identify a potential signaling program that couples SE to progenitor cell proliferation. SE triggers CREB-dependent transcription in reactive microglia. As a CREB-target gene, IGF-1 expression is upregulated, and by 2-days post-SE, IGF-1 triggers MAPK pathway activation in progenitor cells and, in turn, an increase in progenitor cell proliferation.
Effect of Reactivity of Organics-Modified Montmorillonite on the Thermal and Mechanical Properties of Montmorillonite/Polyimide Nanocomposites (2000)

Montmorillonite/polyimide (3,3‘,4,4‘-benzophenone tetracarboxylic dianhydride-4,4‘-oxydianiline, BTDA-ODA) nanocomposites displaying different morphological, thermal, and mechanical characteristics were synthesized by involving mono-, di-, and trifunctional group swelling-agent-modified montmorillonite and poly(amic acid). It was found that the dispersion of silicate layers in BTDA-ODA shifted from intercalated to exfoliated structures when the number of functional groups of the swelling agent increased to three as evidenced from X-ray diffraction and transmission electron microscopy studies. The improved morphology of the nanocomposites resulted in their enhanced mechanical and thermal properties. In particular, a 70% increase in Young's modulus, a 50% increase in the maximum stress, and a 30% reduction in the coefficients of thermal expansion for the case of BTDA-ODA nanocomposites containing 5 wt % trifunctional group swelling-agent-modified montmorillonite as compared to that of pure BTDA-ODA.
Nonlinear optical crystal development at the USAF Wright Laboratory (2002)

Wright laboratory materials directorate has been the primary DoD organization developing nonlinear optical (NLO) materials. This effort has resulted in numerous successes, especially in the development of new NLO crystals for use in laser sources. These crystals significantly enhance laser performance by making possible wavelength shifting and tunability and higher power. Technical progress has been made in developing several crystals which together cover the spectral range from middle ultraviolet to the far infrared. One crystal in particular, zinc germanium phosphide, has already demonstrated average power of 3.5 watts tunable over much of the mid-infrared atmospheric window. Significant improvements have also been made with extending the transparency range and laser-damage resistance of the KTP family of compounds.
Lasers and optics (2009)

Lasers (the acronym from light amplification by stimulated emission of radiation), with their unique coherent, monochromatic, and collimated beam characteristics, are used in ever-expanding fields of applications. Different applications require laser beams of different pulse duration and output power. Lasers employed for materials processing range from those with a high peak power and extremely short pulse duration to lasers with high-energy continuous-wave output.
Plug-In Hybrid Electric Vehicle Energy Storage System Design: Preprint (2006)

In this article, our aim is to analyze institutional practices guided to promote the development of moral values within the context of military education of Brazilian Army combatant commissioned officers. From a cultural psychological approach, we discuss how social guidance within military culture operates at different levels of the affective-semiotic regulation of individuals, structuring complex experiences that give rise to hypergeneralized meaning fields regarding morality and military values. For this goal, we first introduce some theoretical topics related to values development, emphasizing their affective roots and role in the emergence, maintenance, amplification and attenuation of all relations between the person and the environment. Following a brief discussion on how social institutions try to promote changes in personal values, we provide an overview of values present in the military culture and socialization. Finally, the text focuses on the education of Brazilian Army combatant commissioned officers, describing how practices related to different levels of affective-semiotic experience combine in order to promote the internalization and externalization of specific moral values. We conclude suggesting issues for future investigation.
Micromachined array of electrostatic energy analyzers for charged particles (1994)

The design, fabrication techniques, and first test results of a new type of micromachined energy analyzer for charged particles are presented. The novel design is based on a Bessel Box straight-line geometry with focusing in one dimension. The problem of small acceptance area due to the drastically reduced overall dimensions is accounted for by the use of a parallel array of small analyzers simultaneously. We describe the fabrication of a proof-of-concept micromachined Bessel Box array by means of anisotropic wet etching of 〈110〉 silicon, and we present ray-tracing simulations for a simple geometry. Finally, we show some test results of Auger electrons and discuss possible applications of generic small charged particle analyzers.
Computerized analysis of daily life motor activity for ambulatory monitoring (1997)

The primary goal of an ambulatory monitoring of motor activities (AMMA) system is to document the occurrence of random and spontaneous motor activities (e.g., sitting, lying, standing, walking, running, etc.) of the ambulatory subject in natural environmental circumstances. Much progress has been made in recording fidelity, reduction in energy requirement, fixation of the accelerometers, equipment size and weight, memory capacity and data acquisition. At present, our laboratory is interested in developing an automated off-line AMMA-signal analysis system. The system has to take care of activity (wave) detection, recognition of onsets and endpoints of the various activities (waves), and computation of a set of relevant clinical parameters (e.g., total walking time, number of times rising from a chair, etc.) from long-term recorded data. Two methods are currently being used for computerizing the off-line analysis system: using an artificial neural network and using a set of selected features extracted from the input data. The present paper is aimed at the latter method. The method was successfully applied to long-term recorded data sets of eight male amputees and three other subjects. The primary results indicate that the method is a potentially useful tool to computerize the off-line analysis system.
Biomarkers for acute diagnosis and management of stroke in neurointensive care units (2016)

The effectiveness of current management of critically ill stroke patients depends on rapid assessment of the type of stroke, ischemic or hemorrhagic, and on a patient's general clinical status. Thrombolytic therapy with recombinant tissue plasminogen activator (r-tPA) is the only effective treatment for ischemic stroke approved by the Food and Drug Administration (FDA), whereas no treatment has been shown to be effective for hemorrhagic stroke. Furthermore, a narrow therapeutic window and fear of precipitating intracranial hemorrhage by administering r-tPA cause many clinicians to avoid using this treatment. Thus, rapid and objective assessments of stroke type at admission would increase the number of patients with ischemic stroke receiving r-tPA treatment and thereby, improve outcome for many additional stroke patients. Considerable literature suggests that brain-specific protein biomarkers of glial [i.e. S100 calcium-binding protein B (S100B), glial fibrillary acidic protein (GFAP)] and neuronal cells [e.g., ubiquitin C-terminal hydrolase-L1 (UCH-L1), neuron-specific enolase (NSE), αII-spectrin breakdown products SBDP120, SBDP145, and SBDP150, myelin basic protein (MBP), neurofilament light chain (NF-L), tau protein, visinin-like protein-1 (VLP 1), NR2 peptide] injury that could be detected in the cerebrospinal fluid (CSF) and peripheral blood might provide valuable and timely diagnostic information for stroke necessary to make prompt management and decisions, especially when the time of stroke onset cannot be determined. This information could include injury severity, prognosis of short-term and long-term outcomes, and discrimination of ischemic or hemorrhagic stroke. This chapter reviews the current status of the development of biomarker-based diagnosis of stroke and its potential application to improve stroke care.
Supplementary Legends from Identification of Kinase Inhibitor Targets in the Lung Cancer Microenvironment by Chemical and Phosphoproteomics (2023)

&lt;p&gt;Legends for Supplementary Figures and Tables&lt;/p&gt;
Graphene Oxide Nanocomposite Incorporated Poly(ether imide) Mixed Matrix Membranes for in Vitro Evaluation of Its Efficacy in Blood Purification Applications (2015)

Hemodialysis is one of the most commonly used treatments for patients suffering from irrecoverable kidney damage. In our present work, we investigate poly(ether imide) (PEI) mixed matrix membranes (MMMs) as a potential candidate for hemodialysis applications due to their efficient clearance and high biocompatibility. Graphene oxide (GO) was synthesized by the modified Hummers’ method and was then confirmed by X-ray diffraction spectroscopy, Fourier transform infrared spectroscopy, Raman spectroscopy, and high-resolution transmission electron microscopy. The GO-polyvinylpyrrolidone nanocomposite incorporated PEI MMMs were fabricated by a semiautomatic casting unit using the nonsolvent induced phase separation technique. The effect of the nanocomposite loading ratio was evaluated by water content, ultrafiltration rate, and porosity, which were all found to increase as the nanocomposite content increased. Cross-sectional and top surface morphology was visualized using scanning electron microscopy and atomic force microscopy. The hydrophilicity of these membranes was in consonance with contact angle values. These MMMs demonstrated an increase in biocompatibility: reduced protein adsorption, suppressed platelet adhesion, and lower complement activation. Furthermore, the prolonged blood clotting time is an indication of the heparin mimic anticoagulant properties of these membranes. The cytocompatibility results by 3-(4, 5-dimethyl-2-thiazolyl)-2, 5-diphenyl-tetrazolium bromide assay and live cell/dead cell staining indicated that there was an increase in cell viability. The membranes with 0.1 wt % GO showed an excellent clearance of the model uremic toxins, namely urea, vitamin B-12, and cytochrome-c in vitro. The diffusive permeability of these membranes could be comparable to the existing commercial hemodialysis membranes. Thus, it can be concluded that these membranes containing a composite of both functional nanosheets and bioactive polymers have a tremendous potential to be utilized commercially in hemodialysis modules if shown successful in further in vivo studies with an animal model.
Intraluminal fibrosis in interstitial lung disorders. (1986)

The histopathologic and ultrastructural features of intraluminal organizing and fibrotic changes were studied in open lung biopsies and autopsy specimens from 373 patients with interstitial lung disorders, including hypersensitivity pneumonitis (n = 44), idiopathic pulmonary fibrosis (n = 92), collagen-vascular diseases (n = 20), chronic eosinophilic pneumonia (n = 10), pulmonary histiocytosis X (n-90), pulmonary sarcoidosis (n = 62), pneumoconioses (n = 25), Legionnaire's disease (n = 5), drug- and toxin-induced pneumonitis (n = 4), radiation-induced pneumonitis (n = 2), lymphangioleiomyomatosis (n = 11), and chronic organizing pneumonia of unknown cause (n = 8). Three patterns of intraluminal organization and fibrosis were recognized: 1) intraluminal buds, which partially filled the alveoli, alveolar ducts and/or distal bronchioles; 2) obliterative changes, in which loose connective tissue masses obliterated the lumens of alveoli, alveolar ducts or distal bronchioles, and 3) mural incorporation of previously intraluminal connective tissue masses, which fused with alveolar, alveolar ductal, or bronchiolar structures and frequently became reepithelialized. All three patterns had common morphologic features, suggesting that, regardless of their severity, they resulted from a common pathogenetic mechanism, ie, the migration of activated connective tissue cells, through defects in the epithelial lining and its basement membrane, from the interstitial into the intraluminal compartment. Intraluminal buds were observed most frequently in hypersensitivity pneumonitis, chronic eosinophilic pneumonia, and organizing pneumonia of unknown cause. Mural incorporation and, to a lesser extent, obliterative changes were observed in most interstitial disorders and were very prominent in idiopathic pulmonary fibrosis. Mural incorporation and obliterative changes play an important role in pulmonary remodeling, especially when several adjacent alveoli and/or other air spaces are involved. Under these circumstances, intraluminal organization can mediate the fusion of adjacent alveolar structures by intraluminal connective tissue.
MELDing transactions and objects (1991)

MELD is an experimental object system under development at Columbia University. The object-oriented programming language supports classes, strong typing of instance variables, active values, multiple inheritance, and separate compilation of modular units called features that bundle together related classes and objects. These facilities were developed for an early version of MELD [3, 4], without persistence, concurrency or distribution.
ITensor: Many small improvements (2016)

Product of IndexVal and scalar now works for complex scalars too Combined prime function taking Index objects and function taking IndexType arguments into single function which can take combinations of both. Function findIQInd now returns default-constructed IQIndex if not found; previously would throw an exception. orderedC function now switches ITensor storage to complex if it was real instead of throwing an exception.