gebhart/patrepeval huggingface dataset:
Milk peptides and cardiovascular health - effects on blood pressure and beyond. (2009)

Biologically active, milk protein-derived peptides possess multiple physiological properties related to cardiovascular health, including blood pressure and lipid lowering as well as antithrombotic and antioxidative effects. Of the various peptides, the casein-derived tripeptides isoleucine-proline-proline (IPP) and valine-proline-proline (VPP) have been studied most extensively. IPP and VPP have been consistently shown to have hypotensive effects both in animals and clinical studies. Effects are at least partly mediated via inhibition of angiotensin converting enzyme (ACE), a key regulator of blood pressure. Clinical studies suggest that IPP and VPP may also have beneficial effects on vascular function. Animal studies have shown hypolipidemic effects for whey protein and whey-derived peptides, but more human data are neede. Preliminary evidence exists also on antioxidant and antithrombotic properties of caseinomacropeptides and lactoferrin.
Chirality in Non-Hermitian Photonics (2019)

Chirality is ubiquitous in physics and biology from microscopic to
macroscopic phenomena, such as fermionic interactions and DNA duplication.
In photonics, chirality has traditionally represented differentiated
optical responses for right and left circular polarizations. This
definition of optical chirality in the polarization domain includes
handedness-dependent phase velocities or optical absorption inside chiral
media, which enable polarimetry for measuring the material concentration
and circular dichroism spectroscopy for sensing biological or chemical
enantiomers. Recently, the emerging field of non-Hermitian photonics,
which explores exotic phenomena in gain or loss media, has provided a new
viewpoint on chirality in photonics that is not restricted to the
traditional polarization domain but is extended to other physical
quantities such as the orbital angular momentum, propagation direction,
and system parameter space. Here, we introduce recent milestones in chiral
light-matter interactions in non-Hermitian photonics and show an enhanced
degree of design freedom in photonic devices for spin and orbital angular
momenta, directionality, and asymmetric modal conversion.
Laser de colorante en estado sólido (2012)

La presente patente de invención describe un sistema basado en colorantes orgánicos incorporados en matriz sólida capaz de emitir radiación láser sintonizable de pequeña anchura de línea en la región verde-roja del espectro electromagnético, para aplicaciones optoelectrónicas y biofotónicas. El sistema comprende la cavidad láser, dispersiva o no dispersiva, y el medio activo utilizado para la generación y emisión de luz láser. El medio activo comprende al menos un colorante incluido en una matriz sólida de al menos un polímero. En cavidad no dispersiva cada colorante-matriz emite radiación de banda ancha a una longitud de onda central concreta. En cavidad dispersiva cada combinación colorante-matriz emite radiación de banda estrecha que se puede sintonizar sobre un intervalo de, al menos, 40 nm.
Enhanced contrast ratio and viewing angle of polymer-stabilized liquid crystal via refractive index matching between liquid crystal and polymer network (2013)

Long standing electro-optic problems of a polymer-dispersed liquid crystal (PDLC) such as low contrast ratio and transmittances decrease in oblique viewing angle have been challenged with a mixture of dual frequency liquid crystal (DFLC) and reactive mesogen (RM). The DFLC and RM molecules were vertically aligned and then photo-polymerized using a UV light. At scattering state under 50 kHz electric field, DFLC was switched to planar state, giving greater extraordinary refractive index than the normal PDLC cell. Consequently, the scattering intensity and the contrast ratio were increased compared to the conventional PDLC cell. At transparent state under 1 kHz electric field, the extraordinary refractive index of DFLC was simultaneously matched with the refractive index of vertically aligned RM so that the light scattering in oblique viewing angles was minimized, giving rise to high transmittance in all viewing angles.
Vacuum ultraviolet excimer lasers (1980)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text M. H. R. Hutchinson, "Vacuum ultraviolet excimer lasers," Appl. Opt. 19, 3883-3888 (1980) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Figure S5 from Phase I Dose-Escalation Trial of MIW815 (ADU-S100), an Intratumoral STING Agonist, in Patients with Advanced/Metastatic Solid Tumors or Lymphomas (2023)

&lt;p&gt;T-cell clonal expansion at Cycle 1, Day 8 and Cycle 2, Day 1 relative to pre-treatment, by patient&lt;/p&gt;
Post Acid Treatment on Pressurized Liquid Extracts of Sorghum (Sorghum bicolor L. Moench) Grain and Plant Material Improves Quantification and Identification of 3-Deoxyanthocyanidins (2023)

Sorghum is a unique natural food source of 3-deoxyanthocyanidins (3-DA) polyphenols. This work evaluated the effect of acidification on sorghum extracts post pressurized liquid extraction (PLE) and its ability to increase the identification and quantification of 3-DA. The sorghum genotypes included Sumac and PI570366 (bran only) and SC991 (leaf and leaf sheath tissue). The acidification of the PLE extracts was carried out with methanol–HCl solutions at various concentrations (0, 0.5, 1, 2, and 4%, v/v). Changes in color were determined using L*a*b*. The overall phenolic composition was estimated with the total phenolic content and the DPPH free radical scavenging assays. Quantitative and qualitative chromatographic methods determined the phenolic profile. Color analysis showed that the redness and color saturation increased after acidification. No statistical difference was found in the total phenolic content of the acidified extracts, except for SC991, which was increased. There were no differences in the antioxidant capacity following acidification in all samples. For chromatographic analysis, luteolinidin was predominant in the extracts and the 3-DA content increased after acid treatment. However, some flavonoid and phenolic acid concentrations decreased following acid treatment, including taxifolin, quercetin, and chlorogenic acid. Interestingly, 0.5% v/v HCl acidification was sufficient to increase the color, allow the detection of 5-methoxyluteolinidin, and to increase luteolinidin and 7-methoxyapigenidin by at least twofold.
Social organization and tensions (2013)

The documents in this section deal with social groups and social tensions in Italy: popolo against magnates, noble clans against each another, men against women, young men against city elders, Christians against Jews, freemen against slaves, food riots and tax revolts, acts of resistance and indecency . The chapter focuses on knighthood, towers and vendetta. Although worker unrest is evident in Italian towns from the late thirteenth century, the second half of the fourteenth century saw a rash of working-class revolts, the most famous being that of the Ciompi in Florence has become the 'archetype' of worker insurrections.
Managing context data for smart spaces (2000)

Describes our on-going efforts to construct a service infrastructure to support smart environments. We characterize "fusion services", which extract and infer useful context information from sensor data, using evidential reasoning techniques. We specify sensing services as Bayesian networks and use information-theoretic algorithms to optimize the resources consumed by the rendering of a service. We define a "quality-of-information" metric to characterize sensing service performance. We have implemented an infrastructure for supporting a dynamic set of sensors and services in a smart space. Using this infrastructure and an IEEE 802.11 network, we implemented a probabilistic indoor location system that optimizes the number of sensors consulted when determining the location of a user while maintaining a high degree of accuracy.
Fabrication of multigate power GaAs FET's using electron lithography (1976)

GaAs Schottky barrier FET's employing crossover technology have been fabricated using electron lithography for direct exposure on the wafer. Submicron realignments to gate structures with 2µm minimum feature sizes have been regularly achieved. Direct wafer exposure offers the advantages of high resolution, accurate alignment, flexibility in making design changes and speed in turnaround time but the processes used to pattern the substrate are different than those used with photoresist technology. The processing details as well as D.C. and R.F. results are described. At 4.4 GHz a crossover device with a gate width of 7mm produced a saturation power of 3.1 watts, a 1 db compression power of 2.5 watts and a small signal gain of 5.0 dB. Another device with a gate width of 3.5mm has produced a saturation power of 1.8 watts, a 1 dB compression power of 1.4 watts and a small signal gain of 6.0 dB.
A phase II trial of iniparib (BSI-201) in combination with gemcitabine/carboplatin (GC) in patients with platinum-resistant recurrent ovarian cancer. (2011)

5005 Background: Recurrent ovarian cancer following treatment of advanced disease with platinum-based therapy, such as GC, is associated with poor prognosis and 5-year survival. Addition of iniparib (BSI-201), an anticancer agent with poly (ADP-ribose) polymerase inhibitory activity, to GC potentiates the activity of GC alone, with low incremental toxicities, in patients with metastatic triple-negative breast cancer. (O’Shaughnessy et al. NEJM 2011). This study was designed to evaluate the efficacy and safety of iniparib in combination with GC in patients with platinum-resistant recurrent ovarian cancer. Methods: This multicenter, single-arm phase 2 study used a Simon two-stage design (Stage I n=25; total N=48). Eligible patients were ≥18 years with a histological diagnosis of epithelial ovarian carcinoma, fallopian tube cancer, or primary peritoneal carcinoma and had platinum-resistant disease, defined as relapse 2 to 6 months following primary treatment termination. Carboplatin (AUC 4; IV; days 1), gemcitabine (1000 mg/m2; IV; days 1 and 8), and iniparib (5.6 mg/kg; IV; days 1, 4, 8, and 11) were given on a 21-day cycle. The primary endpoint was overall response rate (ORR; RECIST 1.0); secondary endpoints were safety and progression-free survival (PFS). Results: Analysis from the first 19 patients demonstrated an ORR of 31.6%, consisting of 6 confirmed responses. Early analysis showed a median PFS of 5.9 months (95% CI, 3.0-NE). Safety profiles were consistent with those observed in previous clinical studies of iniparib + GC. Conclusions: Iniparib + GC demonstrated activity in patients with platinum-resistant recurrent ovarian cancer, with promising evidence of response (ORR=31.6%) and substantial increase in median PFS (5.9 months) compared with a previous study of pegylated lioposomal doxorubicin in platinum-resistant recurrent ovarian cancer (ORR=11.7%; median PFS=3.1 months; Mutch et al. JCO 2007). No unexpected toxicities have been reported. Data from all enrolled and dosed patients who have received at least one post-dose scan will be presented. (Clinicaltrials.gov number, NCT01033292).
Therapeutic Efficacy of a Herpes Simplex Virus With Radiation or Temozolomide for Intracranial Glioblastoma After Convection-enhanced Delivery (2008)

The herpes simplex virus-1 (HSV-1)-infected cell protein 0 (ICP0) is an E3 ubiquitin ligase implicated in cell cycle arrest and DNA repair inhibition. Convection-enhanced delivery (CED) of either the replication-defective, ICP0-producing HSV-1 mutant, d106, or the recombinant d109, devoid of all viral genome expression, was performed to determine the in vivo efficacy of ICP0 in combination with ionizing radiation (IR) or systemic temozolomide (TMZ) in the treatment of glioblastoma multiforme (GBM). Intracranial U87-MG xenografts were established in athymic nude mice. Animal survival was determined after mice underwent intracranial CED of either the replication-defective d106 or d109 viruses, or Hanks' balanced salt solution (HBSS), before a single session of whole-brain irradiation or TMZ treatment. Median survival for animals that underwent treatment with HBSS alone, d109 alone, d106 alone, HBSS + IR, HBSS + TMZ, d109 + IR, d106 + IR, and d106 + TMZ was 28, 35, 41, 39, 44, 39, 68 (P < 0.01), and 66 days (P < 0.01), respectively. Intracerebral d106 CED resulted in a significant increase in athymic nude mouse survival when combined with IR or TMZ. d106 CED allows for distribution of HSV-1 in human GBM xenografts and persistent viral infection.
388. Hypersensitivity of MYH16 Fibers (M Fibers) to Myodegeneration in Canine Muscular Dystrophy (2016)

Golden Retriever Muscular Dystrophy (GRMD) dogs frequently develop severe restriction to mouth opening, a condition known as trismus, as one of their earliest physical signs of the disease. Trismus is generally due to fibrosis and/or tonic contraction of the muscles of mastication, the temporalis and the masseter muscle. These muscles are primarily composed of unique myofibers exhibiting a masticatory myosin heavy chain encoded by the MYH 16 gene (M fibers). M fibers have been shown to produce the highest specific force among mammalian myofibers, based on their atypical crossbridge kinetics. Here, we show for a first time a morphological analysis of M fibers for the purposes of their classification, distribution and proportion in the masticatory muscles in normal and GRMD dogs based on immunofluorescence staining by a highly specific anti-MYH16 antibody. Our data demonstrate that in both temporalis and masseter muscles, the predominant M fibers are larger in size when compared to any other striated myofiber. A comparative histological analysis of these and other muscles in GRMD dogs demonstrates a significant relative increase in the proportion of injured, hypercontracted M fibers, a highly significant relative abundance of regenerating fibers expressing the embryonic myosin isoform encoded by the MYH3 gene, and prominent fibrosis when compared to the other affected striated muscles. These results suggest that the higher specific force developed by M fibers, due to the MYH16 encoded MyHC isoform, accelerates the fibers’ rate of degeneration in response to myonecrotizing sarcolemmal injury in the absence of dystrophin. Trismus is not seen in Duchenne MD, suggesting that the deletional frameshift in the human MYH16 gene (Nature 428: 373-4, 415-8) dramatically reduces the relative rate of sarcolemmal injury. These observations may offer novel insights into the physiological role of dystrophin in striated muscles, and provide an especially sensitive test for use in experimental therapeutics in the canine models for DMD.
A Laser Ablation Method for the Spatial Segregation of Enzyme and Redox Sites on Carbon Fiber Microelectrodes (1998)

A laser-generated interference pattern was used to remove enzyme from micrometer-wide stripes on an enzyme-covered carbon fiber microelectrode surface to create regions of facile electron transfer. Fluorescence microscopy was used to visualize fluorophore-tagged enzyme to indicate where the adsorbed enzyme remained on the surface. The electrochemical kinetics of the carbon fiber surface were examined to see if electron-transfer sites could indeed be segregated from enzyme adsorbed across the entire surface. CCD imaging of the electrochemical luminescence of Ru(bpy)3(2+) was used to verify the segregation between photoablated sites (with facile electron-transfer kinetics) and surfaces with adsorbed enzyme (which exhibit slow electron-transfer kinetics). The laser-ablated surface could also be distinguished from the enzyme-covered carbon surface with atomic force microscopy. Thus, photoablation of the surface of a protein-covered carbon fiber microelectrode with an interference pattern generated by a Nd:YAG laser allows the activation of 1.7-micron-wide bands of the electrode surface (available for facile electron transfer) while leaving 2.6-micron-wide enzyme-modified areas intact, thereby producing electroactive regions directly adjacent to enzyme modified regions of the same surface.
Role of synergistic hardening and damage evolution on the stretchability of Al1050/steel/Al1050 sheets (2022)

The configurational design of heterostructures has received considerable attention to achieve a superior combination of strength and ductility. Although heterostructuring for enhanced tensile properties has been widely analyzed, studies on the effect of heterogeneity on sheet formability are still insufficient. Sheet metal formability is one of the most crucial factors for determining hetero-materials’ industrial utilization. To broaden the industrial applicability of heterostructured layered materials, investigating the effects of heterogeneity in the layered structure on formability is necessary. This study investigated the stretch formability of aluminum-steel-aluminum clad sheets using the Erichsen cupping test. The three-layered clad sheets showed additional hardening with a slight increase in ductility owing to hetero-deformation-induced hardening because the strain-hardening exponent has a linear relationship with stretchability or necking resistance. After necking, damage evolution owing to severe internal stress concentration led to delamination at the interface. Interestingly, delamination serves as a block to full cracking through the thickness during forming. This study contributes to the industrial applicability of heterogeneous structuring by elucidating the characteristics of heterogeneity and formability.
Development of tuberculosis in human immunodeficiency virus infected patients receiving antiretroviral therapy (2014)

The risk of TB in patients starting ART is reduced among those with better immunological response, and is unrelated to the virological response. Our results emphasise the need for adjunctive strategies in immunological non-responders to minimise any residual risk of TB.
ChemInform Abstract: A Visible‐Light‐Mediated Oxidative C—N Bond Formation/Aromatization Cascade: Photocatalytic Preparation of N‐Arylindoles. (2013)

Abstract The conditions are compatible with the presence of a variety of functional groups.
Selective Ion Penetration of Graphene Oxide Membranes (2012)

The selective ion penetration and water purification properties of freestanding graphene oxide (GO) membranes are demonstrated. Sodium salts permeated through GO membranes quickly, whereas heavy-metal salts infiltrated much more slowly. Interestingly, copper salts were entirely blocked by GO membranes, and organic contaminants also did not infiltrate. The mechanism of the selective ion-penetration properties of the GO membranes is discussed. The nanocapillaries formed within the membranes were responsible for the permeation of metal ions, whereas the coordination between heavy-metal ions with the GO membranes restricted the passage of the ions. Finally, the penetration processes of hybrid aqueous solutions were investigated; the results revealed that sodium salts can be separated effectively from copper salts and organic contaminants. The presented results demonstrate the potential applications of GO in areas such as barrier separation and water purification.
Nucleotide sequence of the amicyanin gene fromMethylobacterium extorquensAM1 (1991)

The gene for amicyanin from the methylotrophic bacterium, Methylobacterium extorquens AM1 was identified. It encodes a protein consisting of 119 amino acids with a molecular weight of 12,609 kDa. The amino acid sequence shows the presence of a typical leader sequence and signal peptidase recognition site. Two putative hairpin structures were found, one located directly behind the amicyanin gene and another located 50 bp upstream. The same sequence AAAATCCC was found near the start codons for the small subunit of methylamine dehydrogenase and amicyanin, but its significance is not known.
Saccade-related neural communication in the human medial temporal lobe is modulated by the social relevance of stimuli (2022)

Humans predominantly explore their environment by moving their eyes. To optimally communicate and process visual information, neural activity needs to be coordinated with the execution of eye movements. We investigated the coordination between visual exploration and interareal neural communication by analyzing local field potentials and single neuron activity in patients with epilepsy. We demonstrated that during the free viewing of images, neural communication between the human amygdala and hippocampus is coordinated with the execution of eye movements. The strength and direction of neural communication and hippocampal saccade-related phase alignment were strongest for fixations that landed on human faces. Our results argue that the state of the human medial temporal lobe network is selectively coordinated with motor behavior. Interareal neural communication was facilitated for social stimuli as indexed by the category of the attended information.
Supplementary Methods, Figures 1-2, Tables 1-2 from Epigenetically Deregulated microRNA-375 Is Involved in a Positive Feedback Loop with Estrogen Receptor α in Breast Cancer Cells (2023)

Supplementary Methods, Figures 1-2, Tables 1-2 from Epigenetically Deregulated microRNA-375 Is Involved in a Positive Feedback Loop with Estrogen Receptor α in Breast Cancer Cells
Balloon valvuloplasty in dysplastic pulmonary valve stenosis: immediate and intermediate outcomes. (2015)

The results from balloon valvuloplasty in dysplastic pulmonary valve were suboptimal when compared to doming valves. However, it provides a high freedom from re-intervention rate in intermediate follow-up. Intervention at moderate severity can result in better outcome.
Marinobacter salarius sp. nov. and Marinobacter similis sp. nov., Isolated from Sea Water (2014)

Two non-pigmented, motile, Gram-negative marine bacteria designated R9SW1T and A3d10T were isolated from sea water samples collected from Chazhma Bay, Gulf of Peter the Great, Sea of Japan, Pacific Ocean, Russia and St. Kilda Beach, Port Phillip Bay, the Tasman Sea, Pacific Ocean, respectively. Both organisms were found to grow between 4 °C and 40 °C, between pH 6 to 9, and are moderately halophilic, tolerating up to 20% (w/v) NaCl. Both strains were found to be able to degrade Tween 40 and 80, but only strain R9SW1T was found to be able to degrade starch. The major fatty acids were characteristic for the genus Marinobacter including C16:0, C16:1ω7c, C18:1ω9c and C18:1ω7c. The G+C content of the DNA for strains R9SW1T and A3d10T were determined to be 57.1 mol% and 57.6 mol%, respectively. The two new strains share 97.6% of their 16S rRNA gene sequences, with 82.3% similarity in the average nucleotide identity (ANI), 19.8% similarity in the in silico genome-to-genome distance (GGD), 68.1% similarity in the average amino acid identity (AAI) of all conserved protein-coding genes, and 31 of the Karlin's genomic signature dissimilarity. A phylogenetic analysis showed that R9SW1T clusters with M. algicola DG893T sharing 99.40%, and A3d10T clusters with M. sediminum R65T sharing 99.53% of 16S rRNA gene sequence similarities. The results of the genomic and polyphasic taxonomic study, including genomic, genetic, phenotypic, chemotaxonomic and phylogenetic analyses based on the 16S rRNA, gyrB and rpoD gene sequence similarities, the analysis of the protein profiles generated using MALDI-TOF mass spectrometry, and DNA-DNA relatedness data, indicated that strains R9SW1T and A3d10(T) represent two novel species of the genus Marinobacter. The names Marinobacter salarius sp. nov., with the type strain R9SW1(T) ( = LMG 27497(T) = JCM 19399(T) = CIP 110588(T) = KMM 7502(T)) and Marinobacter similis sp. nov., with the type strain A3d10(T) ( = JCM 19398(T) = CIP 110589(T) = KMM 7501T), are proposed.