gebhart/patrepeval huggingface dataset:
XMCM7, a novel member of the Xenopus MCM family, interacts with XMCM3 and colocalizes with it throughout replication. (1996)

A minichromosome maintenance (MCM) protein complex has been implicated in restricting DNA replication to once per cell cycle in Xenopus egg extracts, based on the behavior of a single protein, XMCM3. Using a two-hybrid screen with XMCM3, we have identified a novel member of the MCM family in Xenopus that is essential for DNA replication. The protein shows strong homology to Saccharomyces cerevisiae MCM7 (CDC47) and has thus been named XMCM7. XMCM7 is present in a multiprotein complex with other MCM proteins. It binds to chromatin and is displaced from chromatin by the act of replication. XMCM7 does not preferentially colocalize with sites of DNA replication but colocalizes with XMCM3 throughout replication. Immunodepletion of the MCM complex from Xenopus egg extract by anti-XMCM7 antibodies inhibits DNA replication of sperm and permeable HeLa G2 nuclei but not permeable HeLa G1 nuclei. Replication capacity of the Xenopus egg extract immunodepleted of the MCM complex by anti-XMCM7 antibody can be rescued by MCM proteins eluted from anti-XMCM3 antibody. We conclude that both proteins are present in the same complex in Xenopus egg extract throughout the cell cycle, that they remain together after binding to chromatin and during DNA replication, and that they perform similar functions.
Analytic Hierarchy Process (2005)

Abstract The Analytic Hierarchy Process (AHP) is a theory of relative measurement of intangible criteria. With this approach to relative measurement, a scale of priorities is derived from pairwise comparison measurements only after the elements to be measured are known. The ability to do pairwise comparisons is our biological heritage and we need it to cope with a world where everything is relative and constantly changing and thus, there are no fixed standards to measure things on. In traditional measurement, one has a scale that one applies to measure any element that comes along that has the property the scale is for, and the elements are measured one by one, not by comparing them with each other. In the AHP, paired comparisons are made with judgments using numerical values taken from the AHP absolute fundamental scale of 1 to 9. A scale of relative values is derived from all these paired comparisons and it also belongs to an absolute scale that is invariant under the identity transformation like the system of real numbers. The AHP is useful for making multicriteria decisions involving benefits, opportunities, costs, and risks. The ideas are developed in stages and illustrated with examples of real‐life decisions. The subject is transparent and easy to understand why it is done the way it is along the lines discussed here. The AHP has a generalization to dependence and feedback; the Analytic Network Process (ANP) is not discussed here.
Assembly of the phagocyte NADPH oxidase: binding of Src homology 3 domains to proline-rich targets. (1994)

The NADPH oxidase responsible for generation of superoxide anion and related microbicidal oxidants by phagocytes is assembled from at least five distinct proteins. Two are cytosolic components (p47-phox and p67-phox) that contain Src homology 3 (SH3) domains and associate with a transmembrane cytochrome b558 upon activation. We show here that the SH3 domains of p47-phox bind to proline-rich sequences in p47-phox itself and the p22-phox subunit of cytochrome b558. Binding of the p47-phox SH3 domains to p22-phox was abolished by a mutation in one proline-rich sequence (Pro156-->Gln) noted in a distinct form of chronic granulomatous disease and was inhibited by a short proline-rich synthetic peptide corresponding to residues 149-162 of p22-phox. Expression of mutated p22-phox did not restore oxidase activity to p22-phox-deficient B cells and did not enable p22-phox-dependent translocation of p47-phox to membranes in phorbol ester-stimulated cells. We also show that the cytosolic oxidase components associate with one another through the C-terminal SH3 domain of p67-phox and a proline-rich C-terminal sequence in p47-phox. These SH3 target sites conform to consensus features deduced from SH3 binding sites in other systems. We propose a model in which the oxidase complex assembles through a mechanism involving SH3 domains of both cytosolic proteins and cognate proline-rich targets in other oxidase components.
Utvisning på grund av brott - En studie av institutets teori och praktik (2013)

Endast den som är svensk medborgare har en absolut rätt att vistas i landet. När en utlänning begår ett brott kan detta under vissa förutsättningar leda till att utlänningen utvisas. När domstolen avgör om en utlänning ska utvisas på grund av brott görs en avvägning mellan brottets allvarlighet eller risken för att utlänningen återfaller i brott och utlänningens anknytning till Sverige. Uppsatsen angriper lagstiftningen om utvisning på grund av brott ur tre olika vinklar. Den första angreppssättet är att sätta in utvisningsinstitutet i sitt utlänningsrättsliga, kriminalpolitiska och straffrättsideologiska sammanhang för att således studera utvisningsinstitutets plats i rättssystemet. Det andra angreppssättet är att med en rättsdogmatisk metod utreda gällande rätt på området för att mot bakgrund av rättssäkerheten se om lagstiftningen är godtagbar i fråga om förutsebarhet för den enskilda individen. Det tredje angreppssättet är en studie av hovrättsdomar, där uppsatsen redogör för hur institutet tillämpas i praktiken. Slutsatsen är att utvisningsinstitutet inte har samma utgångspunkt som påföljdssystemet i stort och att detta förmodligen beror på utvisningsinstitutets nära koppling till utlänningskontrollen. Medan påföljdsbestämningen i stort på dömande planet utgår från att påföljden ska stå i proportion till brottet, är utvisningsinstitutets utgångspunkt att utvisningen ska stå i proportion till brottet och de effekter som utvisningen kan tänkas ha för utlänningen. Slutsatsen av rättsutredningen är att lagstiftningen trots sin öppna karaktär, genom Högsta domstolens tolkning har fått en något tydligare innebörd, men att rättsläget ändå kan vara oförutsägbart för den enskilda individen särskilt i fråga om vilken anknytning som kan väga över skälen för utvisning. Men då denna avvägning endast är till fördel för den enskilda bör kraven på förutsebarhet inte ställas lika högt. Studien av hovrättsfall visar att avvägningen mellan skäl för utvisning och utlänningens anknytning till Sverige i de allra flesta fall inte vållar domstolen särskilt stora problem då den utlänning som blir föremål för utvisning sällan har någon anknytning till Sverige. I ett flertal fall förekommer dock att domstolen konstaterar att en utlänning inte har någon anknytning till Sverige trots att denne vistats här under en tid. I dessa fall hade det varit önskvärt, mot bakgrund av kraven på rättssäkerhet, om domstolen utförligare motiverade bristen på anknytning. I de fall där domstolen nämner anknytning till det svenska samhället framstår värderingen av vilken typ av anknytning som tillmäts betydelse som relativt enhetlig. Uppsatsen utmynnar i en rekommendation att ändra lagstiftningen på området för att styrka institutets enhetlighet med påföljdssystemet i stort samt öka rättssäkerheten på området. Rekommendationen är att tydligare koppla de skäl som kan leda till utvisning till brottets straffvärde. En sådan lagstiftning skulle öka förutsebarheten för den enskilde, samtidigt som den hela människan i all sin komplexitet fortfarande skulle kunna beaktas då skäl för utvisning föreligger.
Shared path protection under the risk of high-power jamming (2014)

Transparent optical networks are sensitive to high-power jamming which can degrade legitimate user signals via out-of-band effects in optical fibers and amplifiers, and in-band crosstalk in optical switches. Jamming signals can be inserted in the network either deliberately as an attack, with the intention to deteriorate service, or accidentally, due to component miscon-figuration. This type of attack/failure can potentially propagate through the network causing high data and revenue losses, requiring tailored survivability approaches which take these harmful effects into consideration. Namely, conventional network survivability approaches which protect transmission in case of component faults might not provide adequate protection from jamming since the working and backup paths of a connection may both be within reach of the same jamming signal, even if they are link/node disjoint. Previously, we proposed the concept of an Attack Group (AG) of an all-optical connection (referred to as a lightpath), comprised of all other lightpaths which potentially can affect it in case they carry a high-power jamming signal. Furthermore, we developed a jamming attack-aware dedicated path protection algorithm which establishes AG-disjoint working and backup paths for each connection. Herein, we extend this work by proposing an approach for Jamming-Aware Shared Path Protection (JA-SPP) to achieve survivability in the presence of jamming signals in a more resource-efficient way. We formulate the JA-SPP problem as an Integer Linear Problem (ILP) to obtain optimal solutions for smaller network instances. Comparison with standard SPP for single component faults (without jamming-awareness) shows that JA-SPP obtains solutions which offer protection from high-power jamming, in addition to single component faults, while using the same amount of resources (in terms of link and wavelength usage) as the standard SPP.
Organic/inorganic hybrid solar cells with vertically oriented ZnO nanowires (2009)

Hybrid photovoltaic (PV) devices based on copper-phthalocyanine and fullerene combined with ZnO nanowire array as direct charge transport paths were fabricated. The optimized device with ZnO nanowire has a more than fourfold increase in PV performance than the device without nanowire. The former has an open circuit voltage of 0.46 V, a short circuit current of 3.86 mA/cm2, a fill factor of 0.30, and a power conversion efficiency of 0.53%. The hybrid device based on ZnO nanowires with improved PV performance suggests a way for fabrication of PV device with more exciton dissociation interface area and continuous carrier transport paths.
Physical properties and biological activities of hesperetin and naringenin in complex with methylated β-cyclodextrin (2015)

The aim of this work is to improve physical properties and biological activities of the two flavanones hesperetin and naringenin by complexation with β-cyclodextrin (β-CD) and its methylated derivatives (2,6-di-O-methyl-β-cyclodextrin, DM-β-CD and randomly methylated-β-CD, RAMEB). The free energies of inclusion complexes between hesperetin with cyclodextrins (β-CD and DM-β-CD) were theoretically investigated by molecular dynamics simulation. The free energy values obtained suggested a more stable inclusion complex with DM-β-CD. The vdW force is the main guest-host interaction when hesperetin binds with CDs. The phase solubility diagram showed the formation of a soluble complex of AL type, with higher increase in solubility and stability when hesperetin and naringenin were complexed with RAMEB. Solid complexes were prepared by freeze-drying, and the data from differential scanning calorimetry (DSC) confirmed the formation of inclusion complexes. The data obtained by the dissolution method showed that complexation with RAMEB resulted in a better release of both flavanones to aqueous solution. The flavanones-β-CD/DM-β-CD complexes demonstrated a similar or a slight increase in anti-inflammatory activity and cytotoxicity towards three different cancer cell lines. The overall results suggested that solubilities and bioactivities of both flavanones were increased by complexation with methylated β-CDs.
Fine-grained access control to medical records in digital healthcare enterprises (2015)

Adopting IT as an integral part of business and operation is certainly making the healthcare industry more efficient and cost-effective. With the widespread digitalization of personal health information, coupled with big data revolution and advanced analytics, security and privacy related to medical data — especially ensuring authorized access thereto — is facing a huge challenge. In this paper, we argue that a fine-grained approach is needed for developing access control mechanisms contingent upon various environmental and application-dependent contexts along with provision for secure delegation of access-control rights. In particular, we propose a context-sensitive approach to access control, building on conventional discretionary access control (DAC) and role-based access control (RBAC) models. Taking a holistic view to access control, we effectively address the precursory authentication part as well. The eTRON architecture — which advocates use of tamper-resistant chips equipped with functions for mutual authentication and encrypted communication — is used for authentication and implementing the DAC-based delegation of access-control rights. For realizing the authorization and access decision, we used the RBAC model and implemented context verification on top of it. Our approach closely follows regulatory and technical standards of the healthcare domain. Evaluation of the proposed system in terms of various security and performance showed promising results.
<title>Distributed resource discovery through exchanges of examples and classifiers</title> (2001)

Distributed resource discovery is an essential step for information retrieval and providing information services. This step is usually used for determining the location of an information/data repository that has relevant information/data. The most fundamental challenge is the potential lack of semantic interoperability among these repositories. In this paper, we proposed an algorithm to enable distributed resource discovery. In the proposed method, the distributed repositories achieve pair wise semantic interoperability through the exchange of both examples. For each repository, the local classifier is used to classify the examples sent by the remote repository, and the classifier from the remote repository is used to classify the examples from the local repository. The correspondence of the class labels from two repositories can then be established by examining the classification results.
Enzyme‐catalyzed hydrolysis of 18‐methyl eicosanoic acid‐cysteine thioester (2003)

Abstract 18‐Methyleicosanoic acid (18‐MEA) is the major fatty acid component linked by a cysteine thioester bond within the cuticle at the surface of hair of humans and animals. An excess of 18‐MEA results in fatty hair and a mild method for enzymatic removal was investigated using a range of commercially available hydrolases. Pure 18‐MEA is available from natural sources only in μg quantities, so it was synthesized in gram‐amounts in a 7‐step chemical synthesis at an overall yield of 34%. Starting from 18‐MEA the corresponding thioester with cysteine (Cys‐18‐MEA) serving as model compound was obtained at a yield of 85%. The detection of hydrolases acting on Cys‐18‐MEA was performed using Ellmanns reagent followed by spectrophotometric quantification of 5‐thio‐2‐nitrobenzoic acid at 410 nm. This led to the identification of 6 enzymes with lipase from Pseudomonas cepacia ( Amano PS) as the most active one. With Amano PS, 60% conversion of Cys‐18‐MEA was achieved within 5 h‐reaction time at 30 °C. Preliminary results using samples of human hair were also performed and showed that hydrolytic activity is detectable after incubation of the hair with Amano PS.
Full Range High Dynamic Sensorless Control of Fractional Slot Concentrated Winding Machine (2020)

Due to their high power density, good efficiency and the resulting compactness, permanent magnet synchronous machines are one of the most used machines in traction applications. Especially for wheel hub motors with a high number of poles the fractional slot concentrated winding motor is in terms of highly automated fabrication an attractive alternative to classical motor design with integer-slot distributed-winding. The sensorless control of the machine gives the opportunity in automotive applications, where the environment is very harsh, to renounce the usage of position estimators or to use the control method as a backup. Furthermore a better high dynamic response for sudden changes like slip and slide protection can be achieved. This paper presents a high dynamic sensorless control strategy for a high pole permanent magnet synchronous machine with position estimation from standstill to full speed. For this purpose two control methods are used to cover the whole speed range. In order to accomplish a smooth transition between the two control methods, a transition procedure is proposed. The control strategy was verified experimentally on a high pole Fractional Slot Concentrating Winding Synchronous Machine and the achieved dynamics are demonstrated.
OS 03-03 POSSIBLE DETECTION OF INDIVIDUAL SALT-SENSITIVE BLOOD PRESSURE ELEVATION BY 24-HOUR URINARY SODIUM EXCRETION AND NIGHTTIME HEART RATE (2016)

Objective: Detection of individual difference in salt-induced blood pressure (BP) elevation is important to know who should reduce salt intake for preventing hypertension, but the diagnosis of salt sensitivity requires a time-consuming protocol for testing BP changes in response to salt loading and depletion. Since WHO-CARDIAC Study indicated BP was higher in the people excreting more 24-hour urinary (24U) salt with higher heart rate (HR), ambulatory BP was monitored in a Korean population to investigate the association of nighttime BP and HR with 24-hour urinary salt excretion for detecting salt sensitivity. Design and method: Total 101 males and females aged 30 to 61 years were examined for ambulatory BP (by TM2430, A&D, Tokyo, Japan) and 24U collected by aliquot cups. Results: In the participants excreting 24U salt equal to or higher than (≥) the mean, 10.8 g, nighttime systolic and diastolic BP (SBP, DBP), in the group with HR ≥ the mean, 64.7 beats/min (18) were 119.8/77.1 mmHg, significantly higher than 109.2/67.8 mmHg in the group with HR. Conclusions: Significant nighttime BP elevation could be detected by 24U salt ≥ 10 g and nighttime HR ≥ 65 in this Korean population. Collecting 24U by using a simple aliquot cup and monitoring nighttime HR by a wrist watch-type HR detector are expected to detect salt sensitivity also in other populations, as noted in significantly higher BP in 50 CARDIAC Study populations with higher 24U salt and HR than their means.
Mechanism of Excited-State Intramolecular Proton Transfer for 1,2-Dihydroxyanthraquinone: Effect of Water on the ESIPT (2017)

Mechanisms of excited-state intramolecular proton transfer (ESIPT) of 1,2-dihydroxyanthraquinone (ALR) in ethanol solvent and binary solvent of water and ethanol are investigated using the density functional theory and time-dependent density functional theory. The intramolecular hydrogen bond is found to be reinforced in the excited state based on the bond lengths, bond angles, and infrared vibrational spectra of relevant group. The reinforcement of intramolecular hydrogen bond is attributed to the charge transfer in the excited state, which leads the ESIPT to form a keto isomer. The absorption and fluorescence spectra of ALR in binary solvent with different water percentage are obtained and demonstrate the inhibition effect of water on the ESIPT process, which are consistent with the experimentally observation. Furthermore, more water molecules are considered near the carbonyl group and hydroxyl group related to the intramolecular proton transfer to form intermolecular hydrated hydrogen bond with ALR for clarifying the block mechanism of water on ESIPT. The potential energy curves, frontier molecular orbitals, and NBO analysis are calculated for the several complexes in the ground and excited states. The results show that the interrupt role of water on the ESIPT originated from the forming of hydrated hydrogen bond between the carbonyl oxygen atom and the water molecule, which weakens the intramolecular hydrogen bond associated with proton transfer, increases the energy barrier of ESIPT, and thus precludes the transition of ALR-E to ALR-K in the excited state. In addition, the weakening of intramolecular hydrogen bonds is increased as the water molecule number increases. So the inhibitory effect is enhanced by the water quantity, which reasonably explains the experimental attenuating of keto emission spectra as the water percentage in binary solvent increases.
A review offailure modesandmechanisms ofGaN-based HEMTs (2007)

measurements andDeepLevels Transient Spectroscopy is therefore important fortheidentification of failure Failure modesandmechanisms ofAlGaN/GaNHEMTs, mechanisms ofbothelectronic andoptoelectronic devices. observed during accelerated tests atvarious biasconditions arereviewed. 104 ' 103 IAg i ; 102 640:V M 10° 6-4*\5 iv ~~ ~ ~ ~ ~ ~ ~~ ~101 -8 100 <-81 ~ ~~~~~~~~~ ~ ~ ~ ~~~ 0b
Functional Properties of Minimum Mean-Square Error and Mutual Information (2011)

In addition to exploring its various regularity properties, we show that the minimum mean-square error (MMSE) is a concave functional of the input-output joint distribution. In the case of additive Gaussian noise, the MMSE is shown to be weakly continuous in the input distribution and Lipschitz continuous with respect to the quadratic Wasserstein distance for peak-limited inputs. Regularity properties of mutual information are also obtained. Several applications to information theory and the central limit theorem are discussed.
Using Developer Information as a Factor for Fault Prediction (2007)

We have been investigating different prediction models to identify which files of a large multi-release industrial software system are most likely to contain the largest numbers of faults in the next release. To make predictions we considered a number of different file characteristics and change information about the files, and have built fully- automatable models that do not require that the user have any statistical expertise. We now consider the effect of adding developer information as a prediction factor and assess the extent to which this affects the quality of the predictions.
Observing Virtual Arms that You Imagine Are Yours Increases the Galvanic Skin Response to an Unexpected Threat (2008)

Multi-modal visuo-tactile stimulation of the type performed in the rubber hand illusion can induce the brain to temporarily incorporate external objects into the body image. In this study we show that audio-visual stimulation combined with mental imagery more rapidly elicits an elevated physiological response (skin conductance) after an unexpected threat to a virtual limb, compared to audio-visual stimulation alone. Two groups of subjects seated in front of a monitor watched a first-person perspective view of slow movements of two virtual arms intercepting virtual balls rolling towards the viewer. One group was instructed to simply observe the movements of the two virtual arms, while the other group was instructed to observe the virtual arms and imagine that the arms were their own. After 84 seconds the right virtual arm was unexpectedly "stabbed" by a knife and began "bleeding". This aversive stimulus caused both groups to show a significant increase in skin conductance. In addition, the observation-with-imagery group showed a significantly higher skin conductance (p<0.05) than the observation-only group over a 2-second period shortly after the aversive stimulus onset. No corresponding change was found in subjects' heart rates. Our results suggest that simple visual input combined with mental imagery may induce the brain to measurably temporarily incorporate external objects into its body image.