gebhart/patrepeval huggingface dataset:
CRISPR: A Technical Breakthrough for Tomato Research (2018)

CRISPR is a contemporary biological technology that has attracted the interest of both the science community and the general public. This 4-page article discusses why tomato researchers are interested in CRISPR, what tomato traits have been targeted by CRISPR, and potential applications of CRISPR for tomato genetics and breeding. Written by Tong Geon Lee and published by the UF/IFAS Department of Horticultural Sciences, February 2018. http://edis.ifas.ufl.edu/hs1314
Tick-Borne Borrelia Infection in Sweden (1985)

Spirochetes were cultivated from 17% of 114 Ixodes ricinus ticks in the Stockholm area. Three strains of these spirochetes were selected for studies by electron microscopy. These three strains had definite morphological similarities to spirochetes of the genus Borrelia, as judged by the number of flagella, absence of cytoplasmic tubules, and dimensions. The three strains were not identical, but seemed to consist of two different kinds of cells, one with eight and one with eleven flagella. The three strains were also shown to react with a monoclonal antibody that reacts with Lyme disease spirochetes (Borrelia burgdorferi), but not with strains of other Borreliae, Treponemes, or Leptospiras. These results indicate the possibility of transmission of Borrelia spirochetes from ticks to humans in Sweden. The antibody response to one of the spirochetal strains isolated from Swedish I. ricinus was studied in 37 patients with the typical clinical picture of erythema chronicum migrans (ECM), in 45 patients with chronic meningitis (CMe) cured by high-dose intravenous penicillin, in 298 patients with post-infectious arthritis, and in controls. The antibody response was estimated by indirect immunofluorescence assay (IFA) enzyme-linked immunosorbent assay (ELISA). The antibody levels differed significantly between patients with CMe and healthy individuals (p less than 0.001), both with respect to serum antibody levels and CSF-antibody levels. The antibody levels also differed significantly between patients with ECM and healthy controls as measured by ELISA (p less than 0.05), whereas the difference was not significant as measured by IFA. Five of 298 patients with post-infectious arthritis had higher titers than any of the controls, and two of these five patients had titers higher than any patient with CMe or ECM. These results indicate spirochetal aetiology of ECM, and in some patents with CMe or postinfectious arthritis. As a diagnostic test for ECM, both IFA and ELISA were of limited value, since only 5/37 (14%) ECM patients were positive by IFA, and 14/37 (38%) by ELISA. Regarding patients with CMe, 23/45 (51%) were seropositive by IFA and 30/45 (67%) by ELISA. However, measurement of CSF-antibodies were found to be a more sensitive method than measurement of serum antibodies both by IFA and ELISA, since 38/45 (84%) CMe patients were positive by IFA, and 41/45 (91%) by ELISA. In addition, estimation of CSF antibodies was also found to be a more specific method than estimation of serum antibodies.(ABSTRACT TRUNCATED AT 400 WORDS)
Rejuvenation of epididymal principal cells by prolactin under androgen deficiency. (1994)

Influence of prolactin on the ultrastructure of principal cells lining the epididymal epithelium was investigated in Wistar rats. Orchidectomy produced degenerative changes suggesting that structural integrity of principal cell is maintained by factors originating in the testis. The atrophic changes in the principal cell of ordhidectomised rats were significantly reversed when prolactin was administered to these animals. The number of cells that responded were found to increase with the dose of prolactin injected. On the otherhand, bromocryptine treatment did not appreciably change the ultrastructure of principal cells in orchidectomised rats. Results suggest that prolactin may have a rejuvenating epididymal principal cells in androgen deficient states.
Brentuximab vedotin plus doxorubicin and dacarbazine in nonbulky limited-stage classical Hodgkin lymphoma (2022)

ABVD (Adriamycin, bleomycin, vinblastine, dacarbazine) with or without radiation has been the standard treatment for limited-stage Hodgkin lymphoma (HL) but carries risks of bleomycin lung injury and radiation toxicity. Brentuximab vedotin (BV) is approved with AVD for stage III-IV HL, but carries increased risks of peripheral neuropathy (PN) and neutropenic fever, likely due to overlapping toxicity between BV and vinblastine. We therefore evaluated BV in combination with AD for 4 or 6 cycles based on interim positron emission tomography response. Thirty-four patients with nonbulky stage I-II HL were enrolled. Risk was early favorable in 53% and unfavorable in 47%. The overall and complete response rates (CRRs) were 100% and 97%, respectively, with a 5-year progression-free survival (PFS) of 91%. No differences in outcome were observed based on stage (I vs II) or risk status (early favorable vs unfavorable). The most common adverse events were nausea (85%), peripheral sensory neuropathy (59%), and fatigue (56%). There were no cases of grade-4 neutropenia or neutropenic fever, and no patient received granulocyte-colony stimulating factor. Most cases of PN were grade 1, and no patient experienced grade ≥3 PN. BV-AD produced a high CRR and durable PFS with most patients requiring 4 cycles of therapy. Compared with BV-AVD, the toxicity profile appeared improved, with predominantly grade 1 reversible PN and no case of grade 4 neutropenia or neutropenic fever. This regimen warrants further study in HL and may serve as a backbone for the addition of novel agents. This trial is registered on clinicaltrials.gov (NCT02505269).
Foam breaking — key process in detoxification of kraft mill effluents by foam separation (1977)

Abstract A study was undertaken to demonstrate on pilot plant scale the performance of a turbine foam breaking system and to develop the design parameters for large scale application. Among various configurations a 3‐blade vaned‐disc turbine was found to be optimal for foam breaking. Major process variables controlling foam breaking were system design, tip velocity, rotation speed, and foam load. A foam breaking system with only restricted liquid draw‐off performed 3 ‐ 16 times better than a conventional flow through system. A 38 cm diameter turbine operating at 1800 τ/min (3600 cm/s tip velocity) collapsed up to 1.2 m 3 /min (42 ft 3 /min) of foam. Design equations developed for sizing of foam breakers suggest that a 61 cm (2‐ft) diameter 21 kW turbine will collapse 4.7 m 3 /min of foam. For a 95 × 10 3 m 3 /d foam separation plant, approximately 12 foam breakers are required. Capital costs are estimated at $108,000.
Comparison of pramipexole, fluoxetine, and placebo in patients with major depression This study was conducted at University of Tennessee Medical Center in Memphis; Anxiety and Depression Center in Columbia South Carolina; University of Florida at Gainesville; McMaster University at Ontario; Southlake Professional Group in Renton, Washington; Glenbeigh Hospital of Orlando in Winter Park, Florida; VA Medical Center in Palo Alto, California; and Delaware Valley Research Associates in King of Prussia, Pennsylvania (2000)

Pramipexole, a dopamine D2 receptor agonist, was tested in 174 patients with major depression, with or without melancholia and without psychotic features. Three daily dose levels (0.375 mg, 1.0 mg, and 5.0 mg) were compared to fluoxetine (Prozac) at 20 mg and placebo in a randomized, double-blind, parallel-group study. After a 1 week placebo run-in period, patients were treated for 8 weeks, had a post-study follow-up (week 9), and were evaluated primarily with the Hamilton Psychiatric Rating Scale for Depression (HAM-D), the Montgomery-Asberg Depression Rating Scale (MADRS), and the Clinician's Global Impressions-Severity of Illness scale (CGI-SI). All patients who received one dose of study medication were included in the observed-case analysis (no missing data were replaced). Results indicated that by endpoint (week 8), patients receiving pramipexole at the 1.0 mg per day dose had significant improvement over baseline compared to the placebo group by measure of the HAM-D, MADRS, and CGI-SI. Significant improvement in this dose group was seen at other timepoints as well. The most obvious improvement was seen in the pramipexole 5.0 mg group, although a substantial dropout rate for this group precluded statistical tests vs. placebo late in the study. Patients taking fluoxetine also showed significant improvements at endpoint on the MADRS and earlier in the study on the HAM-D. No new or unusual safety concerns were generated during this study. Pramipexole helped safely alleviate the symptoms of depression at 1.0 mg per day and especially in those patients who could tolerate the escalation to 5 mg per day. Depression and Anxiety 11:58–65, 2000. © 2000 Wiley-Liss, Inc
ChemInform Abstract: A Novel Approach to Optically Active trans‐Benzoperhydroindan (2,3,3a, 3b,4,5‐Hexahydro‐1H‐benz(e)indene). (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Subacute sclerosing panencephalitis (SSPE): isolation of a defective variant of measles virus from brain obtained at autopsy. (1975)

A cytopathic agent causing formation of syncytial giant cells was isolated by co-cultivation of human embryonic lung cells with brain cells obtained at autopsy from a patient with subacute sclerosing panencephalitis. Measles specific intracellular immunofluorescence was detected in syncytial giant cells developed by the agent. Paramyxovirus-like nucleocapsids were observed by electron microscopy in nuclei of the syncytial giant cells. Measles specific immunofluorescence was also detected on the surface of unfixed syncytial giant cells. However, the synycytial giant cells did not produce either virions or hemogglutinin, and did not show hemadsorption of African green monkey red cells. Hence, the newly isolated agent seems to be a defective variant of measles virus, and was designated as the SSPE-"BIKEN" strain.
Osa Protein Constitutes a Strong Oncogenic Suppression System That Can Block vir -Dependent Transfer of IncQ Plasmids between Agrobacterium Cells and the Establishment of IncQ Plasmids in Plant Cells (2004)

The osa (oncogenic suppressive activity) gene of the IncW group plasmid pSa is sufficient to suppress tumorigenesis by Agrobacterium tumefaciens. osa confers oncogenic suppression by inhibiting VirE2 protein export. This result is similar, but not identical, to that of oncogenic suppression by the IncQ plasmid RSF1010. We conducted a series of experiments to compare oncogenic suppression by these two systems. Agrobacterium strains harboring plasmids containing osa are more able to effect oncogenic suppression than are similar strains containing various RSF1010 derivatives. When osa is present within a donor Agrobacterium strain that also carries a derivative of RSF1010, the transfer of RSF1010 derivatives to recipient bacteria and their establishment in plants are blocked. Oncogenic suppression is still effected when the osa gene is integrated into the Agrobacterium chromosome, suggesting that it is the osa gene product that is active in suppression and that suppression does not require a protein-nucleic acid intermediate like that described for IncQ plasmids. Extracellular complementation experiments with tobacco leaf disks indicated that Osa blocks stable transfer of RSF1010 to plant cells by inhibiting transfer of VirE2, which is essential for the transfer of RSF1010 into plant cells, and not by inhibiting the actual transfer of RSF1010 itself. Our results suggest that Osa and RSF1010 cause oncogenic suppression by using different mechanisms.
ChemInform Abstract: Asymmetric Electrophilic α‐Aminoalkylation. Part 8. Syntheses of Optically Active α‐Phenacylpyrrolides and First Asymmetric Total Synthesis of Norruspoline. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Commentary (2002)

Wetzel, F. Todd; Prager, Joshua; Saal, Joel; Slosar, Paul; Straus, Barry; Turk, Dennis; Andersson, Gunnar B.J.; Weinstein, James
Master-slave servo manipulator system for the PRIDE facility (2010)

A prototype of a master-slave servo manipulator system has been developed for the use in the PRIDE (PyRoprocess Integrated inactive DEmonstration) facility. The PRIDE facility is designed to have an argon-atmosphere cell which prohibits direct access by human operators. Therefore, all the operation and maintenance of the process equipment is performed remotely through a master-slave manipulation. In this paper, we describe a motion-decoupled joint design of a cable-driven mechanism, a weight balancing analysis, and an interface system. The prototype manipulator system has been installed at a mock-up facility and the performance test of the manipulator system is currently carried out.
Triallate Mobility in Soils (1976)

Laboratory studies were conducted to measure the relative volatility of triallate [ S -(2,3,3-trichloroallyl) diisopropylthiocarbamate] from soils and to determine the effect of surfactants on triallate mobility. Significant volatilization occurred from continuously moist soils under constant air exposure but triallate did not volatilize more rapidly than herbicides which do not respond to incorporation. Volatilization rates from Ray silt soil fell in the order of propachlor (2-chloro- N -isopropylacetanilide) &gt; triallate &gt; alachlor [2-chloro-2′, 6′-diethyl- N -(methoxymethyl)acetanilide] and from Drummer silty clay loam were propachlor &gt; alachlor &gt; triallate. In suspension studies soils reversibly adsorbed 93 to 98% of the triallate in aqueous solution. With soil at field moisture capacity, the concentration of triallate in soil solution was 13 ppbw without surfactant and 14 ppbw with 3 parts emulsifier blend to 1 part of triallate (w/w). With this level of emulsifier 92% of triallate applied to the soil surface remained in the upper 3 cm of soil following a 15.2-cm simulated rainfall. Without surfactant 99% remained in the upper 3 cm of soil. Lower triallate mobility in moist soils observed in this study coupled with the strong dependence of triallate bioactivity as reported by others strongly suggests that deactivation by dry surface soils rather than volatility is primarily responsible for the triallate response to incorporation.
Correction to “Inhibition of Herpes Simplex Virus Type 1 Attachment and Infection by Sulfated Polyglycerols with Different Architectures” (2021)

RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to "Inhibition of Herpes Simplex Virus Type 1 Attachment and Infection by Sulfated Polyglycerols with Different Architectures"Paria PouyanParia PouyanMore by Paria Pouyan, Chuanxiong NieChuanxiong NieMore by Chuanxiong Nie, Sumati BhatiaSumati BhatiaMore by Sumati Bhatia, Stefanie WedepohlStefanie WedepohlMore by Stefanie Wedepohl, Katharina AchaziKatharina AchaziMore by Katharina Achazi, Nikolaus OsterriederNikolaus OsterriederMore by Nikolaus Osterrieder, and Rainer Haag*Rainer HaagMore by Rainer Haaghttp://orcid.org/0000-0003-3840-162XCite this: Biomacromolecules 2021, 22, 5, 2298Publication Date (Web):April 23, 2021Publication History Published online23 April 2021Published inissue 10 May 2021https://doi.org/10.1021/acs.biomac.1c00483Copyright © 2021 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views621Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts Get e-Alerts
Successful initial ablation therapy contributes to survival in patients with hepatocellular carcinoma (2007)

In HCC patients treated with percutaneous ablation therapy, serum albumin level and initial treatment response are the independent outcome predictors.
The Simplest Test of Inflation Target Credibility (1993)

A simple test of inflation target credibility is constructed by subtracting the maximum and minimum inflation rates consistent with the inflation targets from the yields to maturity on nominal bonds. This results in a target-consistent range of real yields on nominal bonds. If expected real yields, or market real interest rates on real bonds if they are available, fall outside the range of target-consistent real yields, credibility is rejected. Two concepts of credibility, called absolute credibility and credibility in expectation, are distinguished. The credibility of inflation targets of Canada, New Zealand and Sweden are examined diagrammatically.
Transcriptional profiling of Primary Progressive Multiple Sclerosis patients identifies Fast and Slow progression patterns (P1.321) (2018)

To investigate peripheral blood molecular pathways that operate in primary progressive multiple sclerosis (PPMS) and to identify transcriptional patterns associated with fast and slow disability progression
Comparative differentiation and numeration of CFUs from mice infected either by the anemia‐ or polycythemia‐inducing strains of friend viruses (1974)

Abstract A comparative study of alterations in the CFU (colony‐forming unit) compartment of susceptible mice infected either with the anemia‐ (FVA) or the polycythemia‐inducing Friend virus (FVP) indicated that: (1) Whatever the type of virus used, the absolute number of CFU is increased in the spleen and in the blood; (2) The splenic CFU augmentation parallels the increase in cellularity so that the CFU concentration remains equal to that of control spleens; (3) Circulation of the CFU in the peripheral blood is multiplied by a factor of about 100 in FVA‐infected mice and 500 in FVP‐infected mice 25 days after infection; (4) In the femoral bone marrow, the CFU number is either unaltered (FVP infection) or decreased (FVA infection). Stem cells from leukemic mice are able to give rise to colonies of differentiated hematopoietic cells as do control CFU. The distribution of the various types of colonies is similar between the different tissues and the different groups of donors. Despite considerable differences between FVA and FVP pathological erythropoiesis, no qualitative discrepancies are observed between the population sizes and the differentiating abilities of the pluripotential stem‐cell compartment. The increase in number of CFU appears to be incidental to the oncogenic action of the virus at the level of the erythroid precursor cells.
Entwicklung eines impedimetrischen Biosensors für den Nachweis von Antigliadin Autoantikörpern (2007)

In der vorliegenden Arbeit wurde ein Biosensor für den Nachweis von Antikörpern gegen Gliadin entwickelt. Gliadine sind Bestandteile der Getreideglutene und verantwortlich für die Manifestation der Zöliakie (Gluten-Unverträglichkeit). Der Biosensor basiert auf der Immobilisierung von Gliadin auf Goldelektroden, die zuvor mit Polystyrensulfonsäure beschichtet worden waren. Die erfolgreiche Immobilisierung wurde mit Hilfe der Quarzmikrowaage dokumentiert. Die Antigen-Antikörper-Bindung konnte durch die Inkubation mit einem Peroxidase-markierten Zweitantikörper und der enzymatischen Oxidation von 3-Amino-9- Ethylcarbazol (AEC) verstärkt werden. Die Zunahme in der Elektrodenisolierung durch die Bindungs- und Ablagerungsreaktion konnte durch elektrochemische Impedanzspektroskopie (EIS) in Anwesenheit des Hexacyanoferrat- Redoxsystems gemessen werden. Die Spektren wurden mit Hilfe eines Randles-Ersatzschaltbildes ausgewertet. Hierbei konnte eine Zunahme im Ladungstransferwiderstand festgestellt werden, die pro portional zur Antigliadin-Antikörperkonzentration, im Bereich von 10-8 M bis 10-6 M, war. Mit Hilfe dieses Sensors wurden schließlich humane Seren hinsichtlich ihrer Konzentration an Gliadinantikörpern, sowohl für Immunglobuline vom Typ IgG als auch IgA, untersucht.
Fluorescence reaction for amino acids (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFluorescence reaction for amino acidsMarc. RothCite this: Anal. Chem. 1971, 43, 7, 880–882Publication Date (Print):June 1, 1971Publication History Published online1 May 2002Published inissue 1 June 1971https://pubs.acs.org/doi/10.1021/ac60302a020https://doi.org/10.1021/ac60302a020research-articleACS PublicationsRequest reuse permissionsArticle Views5563Altmetric-Citations1121LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Modeling Techniques for Periodic Vehicle Routing Problems (2006)

This paper presents a continuous approximation model for the Period Vehicle Routing Problem with Service Choice (PVRP-SC). The PVRP-SC is a variant of the Period Vehicle Routing Problem where the visit frequency to nodes is a decision of the model which can result in more efficient vehicle tours and/or greater service benefit to customers. The continuous approximation model can facilitate strategic and tactical planning of periodic distribution systems and evaluate the value of service choice. Further, results from the continuous model can provide guidelines for constructing solutions to the discrete PVRP-SC.