gebhart/patrepeval huggingface dataset:
Kernel decomposition of time-frequency distributions (1994)

Bilinear time-frequency distributions (TFDs) offer improved time-frequency resolution over linear representations, but suffer from difficult interpretation, higher implementation cost, and the lack of associated low-cost signal synthesis algorithms. In the paper, the authors introduce some new tools for the interpretation and quantitative comparison of high-resolution TFDs. These tools are used in related work to define low-cost high-resolution TFDs and to define linear, low-cost signal synthesis algorithms associated with high-resolution TFDs. First, each real-valued TFD is associated with a self-adjoint linear operator /spl psi/. The spectral representation of /spl psi/ expresses the TFD as a weighted sum of spectrograms (SPs). It is shown that the SP decomposition and Weyl correspondence do not yield useful interpretations for high-resolution TFDs due to the fact that /spl psi/ is not positive.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Supplementary Fig. S3 from Combining miR-10b–Targeted Nanotherapy with Low-Dose Doxorubicin Elicits Durable Regressions of Metastatic Breast Cancer (2023)

&lt;p&gt;Supplementary Fig. S3. Effect of miR-10b knock-out on the phenotype of human metastatic breast cancer cells.&lt;/p&gt;
The ACQUIRE mechanism for efficient querying in sensor networks (2003)

We propose a novel and efficient mechanism for obtaining information in sensor networks which we refer to as ACQUIRE. In ACQUIRE an active query is forwarded through the network, and intermediate nodes use cached local information (within a look-ahead of d hops) in order to partially resolve the query. When the query is fully resolved, a completed response is sent directly back to the querying node. We take a mathematical modelling approach in this paper to calculate the energy costs associated with ACQUIRE. The models permit us to characterize analytically the impact of critical parameters, and compare the performance of ACQUIRE with respect to alternatives such as flooding-based querying (FBQ) and expanding ring search (ERS). We show that with optimal parameter settings, depending on the update frequency, ACQUIRE obtains order of magnitude reduction over FBQ and potentially over 60% reduction over ERS in consumed energy.
Oxide Growth on Etched Silicon in Air at Room Temperature (1975)

Oxide growth on etched silicon wafers at room temperature was studied as a function of etching procedure, wafer orientation, dopant concentration, and exposure to ultraviolet light. An impurity film was rapidly deposited on the silicon surface after etching with hydrofluoric acid. Impurity adsorption was distinguished from oxide growth by x‐ray photoelectron spectroscopy (ESCA). The impurity film greatly reduced the initial oxide growth rate when compared with oxide growth on a cleaved silicon surface. The thickness of oxide films formed on etched surfaces was determined and compared using ESCA and ellipsometry.
ATP-Binding Cassette Transporter G1 Intrinsically Regulates Invariant NKT Cell Development (2012)

ATP-binding cassette transporter G1 (ABCG1) plays a role in the intracellular transport of cholesterol. Invariant NKT (iNKT) cells are a subpopulation of T lymphocytes that recognize glycolipid Ags. In this study, we demonstrate that ABCG1 regulates iNKT cell development and functions in a cell-intrinsic manner. Abcg1(-/-) mice displayed reduced frequencies of iNKT cells in thymus and periphery. Thymic iNKT cells deficient in ABCG1 had reduced membrane lipid raft content, and showed impaired proliferation and defective maturation during the early stages of development. Moreover, we found that Abcg1(-/-) mice possess a higher frequency of Vβ7(+) iNKT cells, suggesting alterations in iNKT cell thymic selection. Furthermore, in response to CD3ε/CD28 stimulation, Abcg1(-/-) thymic iNKT cells showed reduced production of IL-4 but increased production of IFN-γ. Our results demonstrate that changes in intracellular cholesterol homeostasis by ABCG1 profoundly impact iNKT cell development and function.
Engineered bacteriophage targeting gene networks as adjuvants for antibiotic therapy (2009)

Antimicrobial drug development is increasingly lagging behind the evolution of antibiotic resistance, and as a result, there is a pressing need for new antibacterial therapies that can be readily designed and implemented. In this work, we engineered bacteriophage to overexpress proteins and attack gene networks that are not directly targeted by antibiotics. We show that suppressing the SOS network in Escherichia coli with engineered bacteriophage enhances killing by quinolones by several orders of magnitude in vitro and significantly increases survival of infected mice in vivo. In addition, we demonstrate that engineered bacteriophage can enhance the killing of antibiotic-resistant bacteria, persister cells, and biofilm cells, reduce the number of antibiotic-resistant bacteria that arise from an antibiotic-treated population, and act as a strong adjuvant for other bactericidal antibiotics (e.g., aminoglycosides and beta-lactams). Furthermore, we show that engineering bacteriophage to target non-SOS gene networks and to overexpress multiple factors also can produce effective antibiotic adjuvants. This work establishes a synthetic biology platform for the rapid translation and integration of identified targets into effective antibiotic adjuvants.
Coronary angiography using laser plasma sources: X-ray source efficiency and optimization of a bent crystal monochromator (2001)

A monochromator has been developed for coronary angiography, comprising a single bent crystal of silicon in Laue transmission geometry. K spectra of laser irradiated solid tin and tantalum (Z=50 and 73, respectively) targets were measured. The high resolution crystal spectrometer resolve the Sn and Ta Kα doublets, allowing in a proof-of-principle experiment the absolute Kα photon numbers emitted by the source to be determined. The Ta Kα yield is measured as a function of the laser pulse energy, allowing an assessment to be made of the suitability of such sources for medical applications.
Catalytic decomposition of methane into hydrogen and high-value carbons: combined experimental and DFT computational study (2021)

Thermocatalytic decomposition (TCD) of methane can produce hydrogen and valuable nanocarbon co-products with low to near-zero CO<sub>2</sub> emission.
Characterization of the interface between cellulosic fibers and a thermoplastic matrix (1994)

The applicability of the microbond test to evaluate the interfacial properties between cellulosic fibers and thermoplastics was studied. Acetylation and heat treatment were applied to modify the surface of cellulosic fibers (rayon, cotton, and wood). The apparent diameters and surface free energies of the fibers were estimated by dynamic contact angle (DCA) analysis. Interfacial shear strengths between the cellulosic fibers and the polystyrene matrix were determined using the microbond test method. The test results indicate that acetylation increases the total surface free energy of the wood fibers, whereas heat treatment dramatically decreases the surface free energy of all cellulosic fibers tested. For heat treated and acetylated fibers, the greater the surface free energy, the greater the interfacial shear strength (ISS) regardless of fiber types. For control group fibers, a low ISS exists even though the fibers have high surface free energies because of the formation of a weak boundary layer. The high ISS between the acetylated wood fiber and the polystyrene matrix is attributed to the improved wetting and spreading of the melting polystyrene on the acetylated wood fiber surfaces. As such, the interfacial properties between the cellulosic fibers and polystyrene matrix system can be successfully characterized by dynamic contact angle and microbond test.
Development of contact recording head for HDD (1997)

A novel contact recording slider design for HDD, which continuously contacts a disk surface, was investigated. The design of the slider, which has a wide air bearing surface in the front and a contact portion in the rear, enables precise division of suspension load between hydrodynamic force and contact force under certain tolerances. Therefore, stable contact between the slider and the disk is accomplished with small contact force, and the wear of the slider can be reduced. Experiment shows the small spacing fluctuation (<5 nm) at the contact portion with small contact force (<200 uN).
Spatial-modulated physical-layer network coding based on block Markov superposition transmission for maritime relay communications (2020)

As an alternative to satellite communications, multi-hop relay networks can be deployed for maritime long-distance communications. Distinct from terrestrial environment, marine radio signals are affected by many factors, e.g., weather conditions, evaporation ducting, and ship rocking caused by waves. To ensure the data transmission reliability, the block Markov superposition transmission (BMST) codes, which are easily configurable and have predictable performance, are applied in this study. Meanwhile, the physical-layer network coding (PNC) scheme with spatial modulation (SM) is adopted to improve the spectrum utilization. For the BMST-SM-PNC system, we propose an iterative algorithm, which utilizes the channel observations and the a priori information from BMST decoder, to compute the soft information corresponding to the XORed bits constructed by the relay node. The results indicate that the proposed scheme outperforms the convolutional coded SM-PNC over fast-fading Rician channels. Especially, the performance can be easily improved in high spatial correlation maritime channel by increasing the memory m.
An Unsupervised Classification Method for Flame Image of Pulverized Coal Combustion Based on Convolutional Auto-Encoder and Hidden Markov Model (2019)

Combustion condition monitoring is a fundamental and critical issue that needs to be addressed in the wide-load operation of coal-fired boilers. In this paper, an unsupervised classification framework based on the convolutional auto-encoder (CAE), the principal component analysis (PCA), and the hidden Markov model (HMM) is proposed to monitor the combustion condition with the uniformly spaced flame images, which are collected from the furnace combustion monitoring system. First, CAE is adopted to extract the features from the flame images, which obtain the sparse representations in the images. Then, PCA is applied to project the feature vectors into the orthogonal space for robustness and computation efficiency. Finally, a HMM is built to calculate the corresponding optimal states by learning the temporal behaviors in the compressed representations. A coal combustion adjustment experiment was conducted in a 660 MW opposed-firing boiler, and the sequential 14,400 flame images with three different combustion states were obtained to evaluate the effectiveness of the proposed approach. We tested six different compression dimensions of the latent variable z in the CAE model and ensured that the appropriate compress parameter was 1024. The proposed framework is compared with five other methods: the CAE + Gaussian mixture model (GMM), CAE + Kmean, the CAE + fuzzy c-mean method, CAE + HMM, and the traditional handcraft feature extraction method (TH) + HMM. The results show that the proposed framework has the highest classification accuracy (95.25% for the training samples and 97.36% for the testing samples) and has the best performance in recognizing the semi-stable state (85.67% for the training samples and 77.60% for the testing samples), indicating that the proposed framework is capable of identifying the combustion condition, changing when the combustion deteriorates as the coal feed rate falls.
Scheduling algorithms for shared-fiber-delay-line optical cell switches (2004)

In a shared-fiber-delay-line (shared-FDL) optical cell switch, delayed cells must be assigned delay values and FDL routes before entering the switch. We propose three new cell scheduling algorithms for the shared-FDL optical cell switches.
Cannabinoid Combination Induces Cytoplasmic Vacuolation in MCF-7 Breast Cancer Cells (2020)

This study evaluated the synergistic anti-cancer potential of cannabinoid combinations across the MDA-MB-231 and MCF-7 human breast cancer cell lines. Cannabinoids were combined and their synergistic interactions were evaluated using median effect analysis. The most promising cannabinoid combination (C6) consisted of tetrahydrocannabinol, cannabigerol (CBG), cannabinol (CBN), and cannabidiol (CBD), and displayed favorable dose reduction indices and limited cytotoxicity against the non-cancerous breast cell line, MCF-10A. C6 exerted its effects in the MCF-7 cell line by inducing cell cycle arrest in the G<sub>2</sub> phase, followed by the induction of apoptosis. Morphological observations indicated the induction of cytoplasmic vacuolation, with further investigation suggesting that the vacuole membrane was derived from the endoplasmic reticulum. In addition, lipid accumulation, increased lysosome size, and significant increases in the endoplasmic reticulum chaperone protein glucose-regulated protein 78 (GRP78) expression were also observed. The selectivity and ability of cannabinoids to halt cancer cell proliferation via pathways resembling apoptosis, autophagy, and paraptosis shows promise for cannabinoid use in standardized breast cancer treatment.
Corynebacterium diphtheriae : Identification and Characterization of a Channel-Forming Protein in the Cell Wall (2007)

The cell wall fraction of the gram-positive, nontoxic Corynebacterium diphtheriae strain C8r(-) Tox- (=ATCC 11913) contained a channel-forming protein, as judged from reconstitution experiments with artificial lipid bilayer experiments. The channel-forming protein was present in detergent-treated cell walls and in extracts of whole cells obtained using organic solvents. The protein had an apparent molecular mass of about 66 kDa as determined on Tricine-containing sodium dodecyl sulfate-polyacrylamide gel electrophoresis gels and consisted of subunits having a molecular mass of about 5 kDa. Single-channel experiments with the purified protein suggested that the protein formed channels with a single-channel conductance of 2.25 nS in 1 M KCl. Further single-channel analysis suggested that the cell wall channel is wide and water filled because it has only slight selectivity for cations over anions and its conductance followed the mobility sequence of cations and anions in the aqueous phase. Antibodies raised against PorA, the subunit of the cell wall channel of Corynebacterium glutamicum, detected both monomers and oligomers of the isolated protein, suggesting that there are highly conserved epitopes in the cell wall channels of C. diphtheriae and PorA. Localization of the protein on the cell surface was confirmed by an enzyme-linked immunosorbent assay. The prospective homology of PorA with the cell wall channel of C. diphtheriae was used to identify the cell wall channel gene, cdporA, in the known genome of C. diphtheriae. The gene and its flanking regions were cloned and sequenced. CdporA is a protein that is 43 amino acids long and does not have a leader sequence. cdporA was expressed in a C. glutamicum strain that lacked the major outer membrane channels PorA and PorH. Organic solvent extracts of the transformed cells formed in lipid bilayer membranes the same channels as the purified CdporA protein of C. diphtheriae formed, suggesting that the expressed protein is able to complement the PorA and PorH deficiency of the C. glutamicum strain. The study is the first report of a cell wall channel in a pathogenic Corynebacterium strain.
Vinyl-Substituted Silphenylene Siloxane Copolymers:  Novel High-Temperature Elastomers (1999)

The synthesis of a series of vinyl-substituted silphenylene siloxane polymers of high molecular weight is described. 29Si NMR spectroscopy indicates that the polymers possess an exactly alternating microstructure of the silphenylene and siloxane moieties. The materials are completely amorphous with glass transition temperatures between −60 and −86 °C. All polymers degrade thermally only above 500 °C under both oxidative or inert atmosphere. The char yields at 900 °C increase with increasing vinyl content from 30% up to almost 70%. Cross-linking of a small fraction of vinyl groups by hydrosilylation gives materials with elastomeric properties. Dynamic mechanical experiments indicate that the bulk of vinyl groups cross-links thermally at temperatures above 230 °C. Therefore, the temperature window for possible applications of these materials as fire-safe elastomers extends from about −86 °C to approximately 230 °C.
Novel Speed Bumps Design and Optimization for Vehicles' Energy Recovery in Smart Cities (2012)

Recently the technology development and increasing amounts of investment in renewables has led to a growing interest towards design and optimization of green energy systems. In this context, advanced Computational Intelligence (CI) techniques can be applied by engineers to several technical problems in order to find out the best structure and to improve efficiency in energy recovery. This research promises to give new impulse to using innovative unconventional renewable sources and to develop the so-called Energy Harvesting Devices (EHDs). In this paper, the optimization of a Tubular Permanent Magnet-Linear Generator for energy harvesting from vehicles to grid is presented. The optimization process is developed by means of hybrid evolutionary algorithms to reach the best overall system efficiency and the impact on the environment and transportation systems. Finally, an experimental validation of the designed EHD prototype is presented.
Structural and electrical properties of argyrodite-type Cu7PS6 crystals (2018)

Cu 7 PS 6 crystals were grown using direct crystallisation from the melt (Bridgman–Stockbarger technique). The crystal structure of Cu 7 PS 6 was determined by X-ray powder diffraction. Cu 7 PS 6 crystallise in the cubic structure, space group P 2 1 3 (No. 198), the lattice parameter a = 9.6706(1) Å, formula units per cell Z = 4. Electrical properties of Cu 7 PS 6 crystals were studied in the frequency range 10–10 10 Hz and in the temperature interval 296–351 K. The performed analysis shows that the Cu 7 PS 6 crystals are mixed electron-ionic conductors with some growth defects.
Closed-Loop Thrust and Pressure Profile Throttling of a Nitrous-Oxide HTPB Hybrid Rocket Motor (2012)

Hybrid motors that employ non-toxic, non-explosive components with a liquid oxidizer and a solid hydrocarbon fuel grain have inherently safe operating characteristics. The inherent safety of hybrid rocket motors o ers the potential to greatly reduce overall operating costs. Another key advantage of hybrid rocket motors is the potential for in ight shutdown, restart, and throttle by controlling the pressure drop between the oxidizer tank and the injector. The proposed research designs, develops, and ground tests a closed-loop throttle controller for a hybrid rocket motor using nitrous oxide and hydroxyl-terminated polybutadiene as propellants. The research simultaneously developed closed-loop throttle algorithms and lab scale motor hardware to evaluate the delity of the throttle simulations and algorithms. Initial open-loop motor tests were performed to better classify system parameters and to validate motor performance values. Deep-throttle open-loop tests evaluated limits of stable thrust that can be achieved on the test hardware. Open loop tests demonstrated the ability to throttle the motor to less than 10% of maximum thrust with little reduction in e ective speci c impulse and acoustical stability. Following the openloop development, closed-loop, hardware-in-the-loop tests were performed. The closed loop controller successfully tracked prescribed step and ramp and with a high degree of delity.
Conditionally immortalized human proximal tubular epithelial cells isolated from the urine of a healthy subject express functional calcium-sensing receptor (2015)

The calcium-sensing receptor (CaSR) is a G protein-coupled receptor, which plays an essential role in regulating Ca(2+) homeostasis. Here we show that conditionally immortalized proximal tubular epithelial cell line (ciPTEC) obtained by immortalizing and subcloning cells exfoliated in the urine of a healthy subject expresses functional endogenous CaSR. Immunolocalization studies of polarized ciPTEC revealed the apical localization of the receptor. By Western blotting of ciPTEC lysates, both monomeric and dimeric forms of CaSR at 130 and ∼250 kDa, respectively, were detected. Functional studies indicated that both external calcium and the positive CaSR allosteric modulator, NPS-R568, induced a significant increase in cytosolic calcium, proving a high sensitivity of the endogenous receptor to its agonists. Calcium depletion from the endoplasmic reticulum using cyclopiazonic acid abolished the increase in cytosolic calcium elicited by NPS-R568, confirming calcium exit from intracellular stores. Activation of CaSR by NPS-R significantly reduced the increase in cAMP elicited by forskolin (FK), a direct activator of adenylate cyclase, further confirming the functional expression of the receptor in this cell line. CaSR expressed in ciPTEC was found to interact with Gq as a downstream effector, which in turn can cause release of calcium from intracellular stores via phospholipase C activation. We conclude that human proximal tubular ciPTEC express functional CaSR and respond to its activation with a release of calcium from intracellular stores. These cell lines represent a valuable tool for research into the disorder associated with gain or loss of function of the CaSR by producing cell lines from patients.
ChemInform Abstract: LIGAND STRUCTURE AND COMPLEXATION, XXV. NEW AZA CROWN ETHER CYCLIZATIONS WITHOUT USE OF THE DILUTION PRINCIPLE (1978)

Abstract Bei Versuchen zur Synthese offenkettiger Kronenether‐Bausteine wurden überraschenderweise die Cyclen (II), (IV), (VI), (IX), (X) und (XII) isoliert, deren Bildung durch Templat‐, sterische und Entropie‐Effekte erklärt wird.
PLZ-SYS PL/65 PL/M RPL/2 Mistral PLZ Special Feature A Survey of Microprocessor Languages (1980)

At least 20 different microprocessor languages are in use today—spawned in part by marketing policies, fashion, and the "not invented here" attitude. Here is an attempt at orderly classification.
Design on Publish/Subscribe Message Dissemination for Vehicular Networks with Mobile Edge Computing (2017)

The safety messages in vehicular networks require to be transmitted as fast as possible. On the other hand, the high mobility of vehicles poses an other major challenge on efficient message disseminations. In this paper, we present a design on publish/subscribe message dissemination (DPSMD) for vehicular networks with Mobile Edge Computing (MEC). Our design consists of message brokers that provide message exchange services, message handlers that excavate the potential value of messages and message hubs that bridge different parts of the system. MEC can be made use of in DPSMD to provide low-latency message services for vehicle users, while wide- area message disseminations are also well supported. The detailed descriptions is then given, including topic designs, subscription, publishing processes and message validating. Finally, a testbed is built up to evaluate the performance of the DPSMD in terms of the average time of message distributions.
Pneumococcal vaccine in Aboriginal children : a randomized controlled trial (1986)

tag=1 data=Pneumococcal vaccine in Aboriginal children : a randomized controlled trial..

tag=2 data=Douglas, R.M.%Hansman, D.%McDonald, B.%Paton, J.%Kirke, K.

tag=3 data=Community Health Studies, Vol X, No 2

tag=6 data=^d ^m ^y1986

tag=8 data=HEALTH SERVICES%DISEASES

tag=9 data=VACCINES

tag=15 data=JOU