gebhart/patrepeval huggingface dataset:
Calibration of the carbon localized vibrational mode absorption line in GaAs (1986)

The residual carbon acceptor concentration [CAs] in three radio-tin-doped, liquid encapsulated Czochralski, GaAs single crystals was estimated from a plot of carrier concentration versus tin concentration determined by radio-tracer counting. Local vibrational mode absorption of CAs in the samples was measured at room temperature and a calibration factor of 8±2×1015 cm−1 obtained. A comparison of this with other determinations suggests that the true calibration factor lies between 8 and 11×1015 cm−1 and that earlier, larger calibration factors should be discounted.
A dual gate flash EEPROM cell with two-bit storage capacity (1997)

In this paper, a dual-gate Flash EEPROM cell is proposed which allows the storage of two bits with only a slight increase in the cell size with respect to the single-bit case. Extensive simulations show that the basic functions of the Flash cell, namely reading, programming and erasing are possible with a suitable setting of the applied voltages. A simplified model based on the equivalent circuit of the cell allows for a qualitative interpretation of the obtained results, providing at the same time useful hints for the optimization of the cell parameters. Moreover, a schematic of the cell array is presented and some issues related to the array organization are briefly discussed.
Reconsideration of Energy Balance in Jiles–Atherton Model for Accurate Prediction of B–H Trajectories in Ferrites (2020)

In this article, the energy balance equation in the original Jiles-Atherton model is revisited. In particular, the assumption that the energy stored in a lossy material is equal to that stored in a lossless material is removed. This modification results in more accurate prediction of B -H trajectories. A new approach to characterize material parameters based on resonant response is also set forth. Extensive experimental validation is provided and model parameters for several common materials are given.
Neuroretinal-Derived Caveolin-1 Promotes Endotoxin-Induced Inflammation in the Murine Retina (2020)

Cav1 expression in the NR compartment promotes the innate TLR4-mediated retinal tissue immune response. Additionally, we have identified novel potential immune modulators differentially expressed with NR-Cav1 depletion. This study further clarifies the role of NR-Cav1 in retinal inflammation.
High-dose cisplatin therapy in ovarian cancer. (1985)

Cisplatin (Platinol) has an important dose-response relationship in ovarian cancer. We have used high-dose cisplatin (40 mg/m2q d X 5) administered in 250 mL 3% saline and 6 L/d of saline hydration in a phase II trial in refractory ovarian cancer patients and together with cyclophosphamide (Cytoxan) (200 mg/m2 qd X 5) in previously untreated advanced ovarian cancer patients. High-dose cisplatin produced a 32% response rate in the phase II trial with a median survival of 12 months for all patients entered in the study and 16 months for responding patients. In previously untreated patients, the preliminary results indicate that intensive treatment with high-dose cisplatin and cyclophosphamide of short duration (3 to 4 months) can produce a high complete remission rate (60%). The dose-limiting toxicity of high-dose cisplatin has been peripheral neuropathy, which limits the number of cycles of high-dose cisplatin that can be administered. Alternative ways to administer higher doses of cisplatin include the use of sodium thiosulfate as a protective agent and the intraperitoneal administration of cisplatin in ovarian cancer patients. These results demonstrate that the cisplatin dose is an important factor in achieving improved results in the treatment of ovarian cancer.
A Multi-Sink Multi-Hop Wireless Sensor Network Over a Square Region: Connectivity and Energy Consumption Issues (2008)

In this paper we present a novel mathematical approach to evaluate the degree of connectivity of a multi- sink wireless sensor network, where sink and sensor nodes are uniformly distributed over a given region. We consider both unbounded and bounded domains, specifically squares, and the impact of border effects is also shown. Random fluctuations as well as a distance-dependent deterministic path-loss are accounted for in our radio channel model. In particular, we deal with randomly shaped wireless footprints, rather than with the less realistic (yet widely adopted) disk model, which is a special case of our channel model. Nodes are organized in a tree-based topology with trees rooted at the sinks (multi-hop communications). The approach allows the computation of the probability that a randomly chosen sensor is not isolated, from which the probability that a certain amount of nodes are connected can be easily derived. The mean energy spent by the network is also accounted for. The model provides guidelines to optimally design the tree-based topology, taking into account connectivity and energy consumption issues.
Microbial species delineation using whole genome sequences (2015)

Increased sequencing of microbial genomes has revealed that prevailing prokaryotic species assignments can be inconsistent with whole genome information for a significant number of species. The long-standing need for a systematic and scalable species assignment technique can be met by the genome-wide Average Nucleotide Identity (gANI) metric, which is widely acknowledged as a robust measure of genomic relatedness. In this work, we demonstrate that the combination of gANI and the alignment fraction (AF) between two genomes accurately reflects their genomic relatedness. We introduce an efficient implementation of AF,gANI and discuss its successful application to 86.5M genome pairs between 13,151 prokaryotic genomes assigned to 3032 species. Subsequently, by comparing the genome clusters obtained from complete linkage clustering of these pairs to existing taxonomy, we observed that nearly 18% of all prokaryotic species suffer from anomalies in species definition. Our results can be used to explore central questions such as whether microorganisms form a continuum of genetic diversity or distinct species represented by distinct genetic signatures. We propose that this precise and objective AF,gANI-based species definition: the MiSI (Microbial Species Identifier) method, be used to address previous inconsistencies in species classification and as the primary guide for new taxonomic species assignment, supplemented by the traditional polyphasic approach, as required.
A new generation of versatile chromogenic substrates for high-throughput analysis of biomass-degrading enzymes (2015)

We show that these substrates can be used to screen the activities of glycosyl hydrolases, lytic polysaccharide monooxygenases and proteases and provide insight into substrate availability within biomass. We envisage that the assays we have developed will be used primarily for first-level screening of large numbers of putative carbohydrate-acting enzymes, and the assays have the potential to be incorporated into fully or semi-automated robotic enzyme screening systems.
Investigating neural mechanisms of change of cognitive behavioural therapy for chronic fatigue syndrome: a randomized controlled trial (2015)

Dutch Trial Register #15852. Registered 9 December 2013 ( http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=4311 ).
Neurochemical markers in CSF of adolescent and adult SMA patients undergoing nusinersen treatment (2019)

We assume that Nf levels in CSF in these patients may result from slow disease progression in this stage of disease, pre-existing loss of motoneurons due to long disease duration besides affection of the LMN only. Therefore, we conclude that Nf levels in CSF do not seem useful as diagnostic and monitoring markers in adolescent and adult SMA type 2 and 3 patients.
Fusion of ML with numerical simulation for optimized propeller design (2023)

In computer-aided engineering design, the goal of a designer is to find an optimal design on a given requirement using the numerical simulator in loop with an optimization method. In this design optimization process, a good design optimization process is one that can reduce the time from inception to design. In this work, we take a class of design problem, that is computationally cheap to evaluate but has high dimensional design space. In such cases, traditional surrogate-based optimization does not offer any benefits. In this work, we propose an alternative way to use ML model to surrogate the design process that formulates the search problem as an inverse problem and can save time by finding the optimal design or at least a good initial seed design for optimization. By using this trained surrogate model with the traditional optimization method, we can get the best of both worlds. We call this as Surrogate Assisted Optimization (SAO)- a hybrid approach by mixing ML surrogate with the traditional optimization method. Empirical evaluations of propeller design problems show that a better efficient design can be found in fewer evaluations using SAO.
Fügebedingte Eigenspannungen und Verzug (1999)

Eigenspannungen und Verzug beim Schweißen dicker Bleche Einleitung Schweißverbindungen und Versuchswerkstoffe Schweißverbindungen Versuchswerkstoffe Prüfverfahren Messungen während des Schweißens Eigenspannungsmessungen nach dem Zerlegeverfahren Bruchmechanische Prüfverfahren Ergebnisse und Diskussion Messungen während des Schweißens Eigenspannungsbestimmungen nach dem Zerlegeverfahren Vergleich der Spannungsbestimmungen nach dem Online und dem Zerlegeverfahren Bruchmechanikversuche Schlußfolgerungen Zusammenfassung Literatur Werkstoff-, Verfahrens- und Geometrieeinflüsse auf den schweißbedingten Verzug Einleitung Versuchswerkstoffe und Versuchsdurchführung Versuchsergebnisse Verzugsbeeinflussende Faktoren und Meßgrößen Verfahrensbedingte Einflüsse Geometriebedingte Einflüsse Werkstoffeinflüsse Verzugsmessungen mit optischen Feldmeßverfahren Allgemeines Eingesetzte Feldmeßverfahren Verzugsmessungen an stumpfgeschweißten Platten Zusammenfassung Literatur Spannungen und Eigenspannungen beim Schweißen und Flammrichten hochfester Feinkornbaustähle Einleitung Versuchsbedingungen und -durchführung Versuchswerkstoffe Probengeometrie und -vorbereitung Versuchseinrichtung und -durchführung Eigenspannungs- und Reaktionsspannungsmessung Versuchsergebnisse Zusammenfassung und Ausblick Literatur Zum Einfluß von Eigenspannungen und Mikrostruktur auf die Kaltrißneigung hochfester Stähle Einleitung Versuchsprogramm Versuchswerkstoffe und Probenherstellung Versuche und Auswertemethoden Ergebnisse und Diskussion Eigenspannungszustände nach dem Schweißen Mikrostruktur nach dem Schweißen Makroeigenspannungszustand in der Umgebung eines Kaltrisses Mikrostruktur im Rißbereich Schlußfolgerungen Literatur Eigenspannungsentstehung in flammrichttypischen Wärmefeldern Einleitung Versuchsprogramm Versuchswerkstoffe Versuchseinrichtungen und Versuchsdurchführung Versuchsergebnisse Experimentelle und rechnerische Modelluntersuchungen an Blechen mit einer zentralen kreisförmigen Erhitzungszone Modelluntersuchungen an Blechen mit trapezförmigen Erhitzungszonen Eigenspannungsmessungen an eingespannten Schweißproben Zusammenfassung Literatur Einfluß von Eigenspannungen auf die Schwingfestigkeit geschweißter Feinkornbaustähle Einleitung Versuchsprogramm Versuchswerkstoffe Probenformen und Schweißausführung Eigenspannungsmessungen, Schwingfestigkeitsversuche und begleitende Untersuchungen Untersuchungsergebnisse Versuche an Proben Versuche an Bauteilproben Diskussion Zusammenfassung Literatur Eigenspannungen und Versagen von Lötverbunden aus Hartmetall und Stahl mit gesteinsbohrerähnlicher Geometrie Einleitung Versuchswerkstoffe und Proben Durchführung der Untersuchungen Untersuchungsergebnisse Eigenspannungszustände Versagensverhalten bei schwingender Beanspruchung Zusammenfassung Literatur
A hierarchical MCM routing using four-via routing (2002)

Recently, multichip modules (MCM) promise to be widely applied due to the advantage of multichip packaging. But, the routing problem for MCM is more difficult than those for VLSI or PCB because of the high packing density and high performance in MCM design. The problem is formulated as a general-area multilayer routing problem, and several algorithms have been proposed. Among these algorithms, a router of four-via routing proposed by Khoo and Cong (see IEEE Trans. CAD, vol.14, no.10, p.1277-90, 1995), named V4R, is the most efficient. V4R routes each net using no more than four interconnection vias, and it can make a better routing result than other MCM routers. However, there are some unresolved issues; for example, nets are routed in order of their terminal positions, so that more routing layers may be required even for short-length nets, or some routing layers are more congested because as many nets as possible are routed on the routing layers under consideration. In this paper, we present a hierarchical routing approach combined with V4R, aiming to improve the above-mentioned issues but also to preserve the characteristics of four-via routing and efficiency of V4R. In our proposed method, first, a routing area is divided into subareas hierarchically and then V4R is repeatedly applied in each subarea in the bottom-up way. Experimental results show that our approach is fairly good in the total routing-length compared with V4R itself.
Genome-Editing and Biomedical Cell Products: Current State, Safety and Efficacy (2018)

Advances in ex vivo technologies of human genome editing have made it possible to develop new approaches to the treatment of genetic, oncological, infectious and other diseases, which may involve the use of biomedical cell products. However, despite the rapid development of these technologies and a large number of clinical trials conducted in many countries around the world, only 4 products (Strimvelis, Zalmoxis, Kymriah and Yescarta) containing ex vivo genetically modified human cells are authorised for use in the European Union and the United States of America. This paper considers three promising technologies (ZFN, TALEN and CRISPR) that allow for easy and effective editing of the genome at the sites of interest, thereby creating a platform for further development of the genetic engineering of human cells. It describes the technology of engineering chimeric antigen receptors (CARs). It also provides data on the efficacy and safety of the approved products: Strimvelis which contains autologous CD34+ cells transduced ex vivo with a retroviral vector containing adenosine deaminase gene, Zalmoxis which contains modified allogeneic T-cells, and two products: Kymriah and Yescarta which contain autologous T-cells with CARs to CD19 antigen, intended for the treatment of CD19+ hematological malignancies.
Éléments optiques biréfringents pour interféromètre à chemins optiques quasi-communs (2014)

Notre étude porte sur l’utilisation de composants optiques biréfringents en tant qu’élément séparateur dans un interféromètre à chemins optiques communs ou quasi-communs. Pour ce type d’interféromètre, la seule différence introduite dans les chemins optiques des faisceaux objet et de référence est celle résultant du relief de la surface testée. Utiliser un élément biréfringent permet de n’avoir qu’un seul élément pour créer les faisceaux référence et objet. On parle d’auto-référencement. Cette propriété désensibilise l’interféromètre vis-à-vis de certaines perturbations extérieures car les faisceaux sont identiquement affectés par celles-ci. La biréfringence des cristaux étant bien souvent faible mais l’interféromètre à construire devant être le plus compact possible, le cisaillement entre les deux faisceaux s’en retrouve faible comparé à la taille de l’objet observé. Une séparation totale des faisceaux émergents n’est possible qu’avec un faisceau « ponctuel » collimaté. La configuration des interféromètres que nous étudierons sera donc différentielle. Deux types d’éléments biréfringents sont étudiés. Le premier est un assemblage de deux cristaux uniaxes taillés à 45° et dont l’orientation de l’axe de l’un des cristaux est tournée à 90° par rapport à celle de l’autre. Il s’agit de la lame de Savart. Les propriétés de cette lame sont détaillées pour justifier l’intérêt de son utilisation dans l’interféromètre. Ce dernier a été utilisé en shearographie et en profilométrie par projection de franges interférométriques. Une installation originale permet l’association des deux méthodes dans un unique montage compact. Dans la configuration proposée, seule l’orientation du cisaillement par l’interféromètre est possible. Pour faire varier la taille du cisaillement, nous avons décidé d’évoluer vers un autre type d’élément biréfringent. L’essor des éléments optiques à biréfringence spatialement variable nous a incités à investiguer cette voie. Ces éléments ont la particularité de permettre une variation spatiale de l’orientation de l’axe optique. Les réseaux de polarisation font partie de cette famille. Après avoir décrit et simulé leur comportement, nous proposons notre propre méthode d’enregistrement de tels réseaux par holographie de polarisation à l’aide d’une lame de Savart. Nous prouvons par la suite que deux réseaux de polarisation circulaire de même orientation et disposés l’un à la suite de l’autre créent un élément séparateur à taille et orientation de cisaillement variables pour un interféromètre à chemins optiques quasi-communs. Nous proposons une application en shearographie.
Microfluidic Rapid and Autonomous Analytical Device (microRAAD) to Detect HIV from Whole Blood Samples (2019)

Abstract Early Human Immunodeficiency Virus (HIV) testing is critical to preventing transmission and providing treatment to HIV-positive individuals, yet an estimated 30% of HIV-positive individuals do not know their status because of barriers to early diagnosis. Readily accessible, highly sensitive, and rapid diagnostic tests would enable patients’ prompt treatment with anti-retroviral therapies and reduce transmission. However, existing HIV diagnostic technologies either do not detect early stages of infection or require multiple days of laboratory processing, delaying notification of patients’ status. Molecular techniques that amplify HIV RNA can detect the earliest stages of infection, within 8-10 days after transmission. However, most of these molecular assays require cold-chain storage of reagents, significant sample preparation, and extensive laboratory infrastructure. To achieve early detection, we developed a reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay with a limit of detection of 10 HIV-1 RNA copies visualized by eye using a lateral flow immunoassay. To demonstrate automated sample-to-answer detection of HIV, we incorporate dried amplification reagents and wax valves in low-cost substrates with resistive heating elements and circuitry. By combining controlled heating with paper’s capillary flow, our assembled device automatically isolates viral particles from human blood samples, amplifies HIV-1 RNA, and transports products to a detection zone. We determine that as few as 10 5 HIV-1 viral particles can be separated from whole blood, amplified, and visually detected within 90 minutes of sample addition into our Microfluidic Rapid and Autonomous Analysis Device (microRAAD). The low-cost and automated attributes of microRAAD demonstrate its utility as a point-of-care testing platform.
First record of Epipompilus excelsus (Bradley, 1944) (Hymenoptera, Pompilidae) as a koinobiont ectoparasitoid of Ariadna mollis (Holmberg, 1876) (Araneae, Segestriidae) (2018)

Epipompilus Kohl comprises 52 species of wasps that are parasitoids of spiders; 16 species occur in the Neotropical region and 36 species occur in the Australian region. The biological knowledge of this genus is limited and its interactions and host spiders are still incipient. Here, we report some behavioural and biological characteristics of E.excelsus , a parasitoid of the tube-dwelling spider Ariadnamollis . We observed an E.excelsus female attacking an adult female of A.mollis in São Paulo, Brazil. We photographed daily the larval development of the wasp, from the egg stage to adult emergence. The entire developmental cycle of the wasp took 24 days. This period was shorter than the developmental periods of wasps belonging to other genera of Pompilidae. Although all species within Pompilidae use spiders as host, they present great behavioural diversity, characterized by different ethological sequences. In conclusion, this study demonstrated that the Neotropical species of Epipompilus exhibit biological characteristics similar to the Australian species, acting as a koinobiont ectoparasitoid, but displays differences in larval morphology. Studies on other species could elucidate the extent of these differences and similarities, contributing to our understanding of the evolutionary history of Epipompilus , and consequently of Pompilidae.
High Occurrence of Simultaneous Mutations in Target Enzymes and MtrRCDE Efflux System in Quinolone-Resistant Neisseria gonorrhoeae (2004)

This study reports simultaneous mutations in fluoroquinolone target enzymes and the MtrRCDE efflux system as a fluoroquinolone-resistant mechanism in N. gonorrhoeae.
Biochemistry of long-chain, nonisoprenoid hydrocarbons. II. Incorporation of acetate and the aliphatic chains of isoleucine and valine into fatty acids and hydrocarbons by Sarcina lutea (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBiochemistry of long-chain, nonisoprenoid hydrocarbons. II. Incorporation of acetate and the aliphatic chains of isoleucine and valine into fatty acids and hydrocarbons by Sarcina luteaPhillip W. Albro and John C. DittmerCite this: Biochemistry 1969, 8, 3, 953–959Publication Date (Print):March 1, 1969Publication History Published online1 May 2002Published inissue 1 March 1969https://pubs.acs.org/doi/10.1021/bi00831a028https://doi.org/10.1021/bi00831a028research-articleACS PublicationsRequest reuse permissionsArticle Views94Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts