gebhart/patrepeval huggingface dataset:
Low‐power global navigation satellite system‐enabled wireless sensor network for acoustic emission localisation in aerospace components (2020)

Structural health monitoring systems for the localisation of acoustic emission (AE) events have been developed in the past few years for aircraft components. However, these systems still require complex and heavy electrical wiring for each sensing device and sophisticated algorithms for the localisation of AE signals, which inevitably increases both weight and costs. This paper reports the creation of a low-power (few hundred mW) and low-weight (~30 g) global navigation satellite system-based wireless sensor network for the identification of AE events in aircraft structures. Each wireless node is instrumented with a low-power micro-controller, a radio frequency wireless transceiver, an analogue-to-digital converter, and a global navigation satellite system receiver for accurate time synchronisation. The AE coordinates and the speed of propagating waves are determined by using a localisation algorithm relying on time of arrival measurements. A peak amplitude detection system is implemented to process the AE data recorded by the wireless sensor network. The AE time features are locally extracted by the individual wireless modules and transferred to a remote processing unit for the execution of the localisation algorithm. Experimental results revealed that AE sources generated by low-velocity impacts are identified with a high level of accuracy. The successful implementation of the proposed wireless sensor network demonstrates its suitability for continuous and autonomous structural health monitoring aerospace applications.
Improved Immune Reconstitution with Low Incidence of Severe Graft-Versus-Host Disease after Transplantation of CD34+ or CD133+ Enriched Stem Cells with Add-Back of Ten Million T-Cells Per Kg. (2004)

Abstract Unrelated donors are commonly used for hematopoietic stem cell transplants, but graft-versus-host disease (GVHD) is a major problem. We investigated whether transplantation of CD34+ or CD133+ enriched stem cells with add-back of ten million T-cells per kg from unrelated donors would prevent acute GVHD in pediatric patients in combination with pharmacologic immunosuppression. Eighteen patients (1 CML in second chronic phase, 2 MDS, 4 ALL in CR1, 4 ALL in CR2, 1 JMML, 1 AML in CR1, 3 AML in CR2, 1 Wiskott-Aldrich syndrome and 1 NHL in CR2) were transplanted with G-CSF mobilized peripheral blood stem cells (PBSC) from HLA-matched unrelated donors (n = 18). Median of age was 8.9 years (0.5 to 18 years). Conditioning regimens were performed according to national therapy protocol guidelines. On the day of transplant patients received a median of 13.5 (4.5 to 30.0 x 106) CD34+ or CD133+ enriched stem cells and an aliquot of unmanipulated PBSC containing 10 x 106 T-cells per kg. GVHD prophylaxis consisted of cyclosporine A (CSA) and short course methotrexate (MTX) on day +1, +3 and +6. Engraftment was rapid with a median of 19.6 days in sixteen patients. Two patients failed to engraft at first. However, full donor chimerism and stable engraftment was achieved in both patients after cessation of CSA treatment and an additional stem cell boost without any reconditioning. One patient with ALL developed acute GVHD grade III (skin and gut) after cessation of CSA treatment, but responded well to treatment with CSA and steroids. None of the other 17 patients developed acute GVHD &amp;gt; grade I. Thirteen are alive and well with a median follow-up of 578 days (101 to 1095 days). Three patients died of severe infectious complications and two due to relapse (JMML, AML). Compared to a historical control group of patients transplanted with highly purified CD34+ selected cells, the group with add-back of 10 x 106 T-cells per kg showed significantly higher T-cell counts (p=0.008, Wilcoxon Rank sum test) on day 90 after transplantation with a median number of six T-cells/μl in the control group and a median number of 294 T-cells/μl in the study group. We conclude that add-back of 10 x 106 T-cells per kg in combination with CSA and short course MTX improves T-cell recovery and appears to be a safe T-cell dosage regarding acute GVHD in the setting of allogeneic peripheral blood stem cell transplantation from unrelated donors.
Efficient regioselective synthesis of triheterocyclic compounds: imidazo[2,1-b]benzothiazoles, pyrimido[2,1-b]benzothiazolones and pyrimido[2,1-b]benzothiazoles (2002)

The preparation and characterisation of triheterocyclic compounds, via annulation reactions, are described. Amidines 1 reacted with substituted bromomethyl compounds, acid chlorides, and acrylic dienophiles to afford the corresponding imidazo[2,1-b]benzothiazoles 2 and pyrimido[2,1-b]benzothiazoles 3 or 4.
Microscopic stress/strain field around a crack tip and fracture process in WC-Co composite. (1990)

On two-phase materials, there exists a microscopic stress/strain field resulting from their microstructure as well as a macroscopic stress/strain field in the region near a crack tip. The fracture behavior of such materials seems to depend strongly on the microscopic stress/strain field. In this paper, the analysis of the microscopic stress/strain field around a crack tip in WC-Co composites, whose Co-volume fractions are 10 %, 30 % and 50 %, has been carried out by the finite element method based on a mechanical model of two-phase sintered materials proposed in a previous paper. In the region ahead of a crack tip, the microscopic stress on WC-grain and the microscopic strain on the Co-phase are larger than the macroscopic stress or strain, respectively. The microscopic stress on WC-grain increases with an increase in Co-volume fraction. From the comparison of the numerical results with the experimental results of fracture toughness in reference, it is suggested that microcracking occurs on the WC-grain ahead of a crack tip before final fracture, and that the process from the microcracking to the final fracture is the toughening mechanism due to ductile fracture of the Co-phase.
Notes 03. Kinematics of motion in cylindrical journal bearings (2009)

Reynolds equation for cylindrical journal bearings. Kinematics of motion and film thickness. Distinction between fixed and rotating coordinates. The pure squeeze velocity vector. Examples of journal motion.
The Upgrade Project at Texas A&M University Cyclotron Institute: Update (2010)

The Cyclotron Institute at Texas A&M University is currently under an upgrade process. The plan is to produce re‐accelerated radioactive ion beams using the recommissioned 88” Cyclotron as a driver and two different devices. The technique for producing radioactive species will be presented.
Successful treatment of secondary macrophage activation syndrome with emapalumab in a patient with newly diagnosed adult-onset Still’s disease: case report and review of the literature (2020)

Here, we present a 22-year-old female patient with adult-onset Still's disease (AOSD) who was newly diagnosed in the setting of secondary macrophage activation syndrome (MAS), a rare, life-threatening inflammatory disease with 50% mortality due to multi-organ failure. She met the diagnostic criteria of AOSD and MAS, while genetic testing excluded primary causes of MAS. She had high fevers, anemia, thrombocytopenia, splenomegaly, hematophagocytosis, and elevated serum ferritin (37,950 ng/mL) and CD25 levels (11,870 pg/mL), which remained unresponsive to corticosteroids and anakinra. Her serum interferon gamma (IFN-γ) levels were elevated (7 pg/mL). She was markedly responsive to IFN-γ blockade with emapalumab that eliminated her fevers and all MAS-associated laboratory abnormalities. This report provides initial evidence for therapeutic efficacy for IFN-γ blockade in AOSD and secondary MAS.
Security and Privacy in Cloud Computing: A Survey (2010)

Cloud Computing is becoming a well-known buzzword nowadays. Many companies, such as Amazon, Google, Microsoft and so on, accelerate their paces in developing Cloud Computing systems and enhancing their services to provide for a larger amount of users. However, security and privacy issues present a strong barrier for users to adapt into Cloud Computing systems. In this paper, we investigate several Cloud Computing system providers about their concerns on security and privacy issues. We find those concerns are not adequate and more should be added in terms of five aspects (i.e., availability, confidentiality, data integrity, control, audit) for security. Moreover, released acts on privacy are out of date to protect users' private information in the new environment (i.e., Cloud Computing system environment) since they are no longer applicable to the new relationship between users and providers, which contains three parties (i.e., Cloud service user, Cloud service provider/Cloud user, Cloud provider). Multi located data storage and services (i.e., applications) in the Cloud make privacy issues even worse. Hence, adapting released acts for new scenarios in the Cloud, it will result in more users to step into Cloud. We claim that the prosperity in Cloud Computing literature is to be coming after those security and privacy issues having be resolved.
Synthesis of Poly(cyclotriphosphazene-co-3,3'-sulfonyldianilide) Microspheres and Their Adsorption of Anionic (Congo Red) Dye (2020)

The cyclomatrix phosphazenes-co-3,3'-sulfonyldianiline PSD-NH2 microspheres with active amino groups on the surface were prepared by precipitation which was used to removal organic dyes from aqueous solution.The synthesized amino cyclomatrix phosphazenes (PSD-NH2) microspheres were characterized by FT-IR, SEM, XPS and XRD.The effects of different pH, sorbent dosage, contact time, initial Congo red (CR) concentration and different temperature on the adsorption of Congo red by the cross-linked microspheres were studied.The experimental data show that the adsorption capacity of PSD-NH2 microspheres on Congo red reaches 186.70 mg/g under the optimal adsorption conditions.It conforms to the pseudo-second-order kinetic equation and Langmuir isotherm model.The selective adsorption mechanism for Congo red dye can be summarized as intermolecular electrostatic interaction, hydrogen bond between PSD-NH2 microspheres adsorbed on the surface and Congo red, π-π and C-H…π stacking and other molecular forces.Thermodynamic studies have shown that the adsorption of Congo redon PSD-NH2 microspheres is endothermic and spontaneous in nature.Thus, amino polyphosphazene (PSD-NH2) microspheres have excellent adsorptionperformance for Congo red.
Narrow linewidth volume bragg grating stabilized thulium fiber laser (2008)

A spectrometer resolution limited 300 pm linewidth is achieved in a volume Bragg grating stabilized Thulium fiber laser. Slope efficiency and output power are comparable to a similar resonator formed by a broadband high reflectivity mirror.
On-line Digestion System for Protein Characterization and Proteome Analysis (2008)

An efficient on-line digestion system that reduces the number of sample manipulation steps has been demonstrated for high-throughput proteomics. By incorporating a pressurized sample loop into a liquid chromatography-based separation system, both sample and enzyme (e.g., trypsin) can be simultaneously introduced to produce a complete, yet rapid digestion. Both standard proteins and a complex Shewanella oneidensis global protein extract were digested and analyzed using the automated online pressurized digestion system coupled to an ion mobility time-of-flight mass spectrometer, an ion trap mass spectrometer, or both. The system denatured, digested, and separated product peptides in a manner of minutes, making it amenable to on-line high-throughput applications. In addition to simplifying and expediting sample processing, the system was easy to implement and no cross-contamination was observed among samples. As a result, the online digestion system offers a powerful approach for high-throughput screening of proteins that could prove valuable in biochemical research (rapid screening of protein-based drugs).
Tuning iridium(iii) phenylpyridine complexes in the “almost blue” region (2004)

We report on the synthesis and photophysical properties of blue emitting iridium(iii) complexes. The use of a negatively charged ligand, such as a triazolyl pyridine, allows a facile preparation, maintaining the high energy emission (blue region) of heteroleptic complexes. We discuss the role played by electron withdrawing substituents of a different nature and also how the substitution position of the same group influences the spectroscopical behaviour.
On the Functionalization of [2.2](1,4)Phenanthrenoparacyclophane (2007)

Abstract Two routes for preparing functionalized [2.2](1,4)phenanthrenoparacyclophanes are described: either the parent system 2 is subjected to electrophilic substitution (bromination, Friedel–Crafts acylation, Rieche formylation: preparation of 5 , 6 , 7 , 11 and 12 ) or the desired substituents are incorporated in the early stages of the synthesis by the preparation of the corresponding functionalized styryl paracyclophanes and their photocyclization to the respective phenanthrenocyclophanes. By these specific routes various bromides ( 22a , b ), ethers ( 28a – c ) and phenols ( 29a , b ) were synthesized. The latter derivatives, on oxidation, furnish para ‐ ( 31 ) and ortho ‐quinonophanes ( 30 , 32 , 33 ), useful substrates for the preparation of cyclophanes containing phenazine subunits ( 36 ). The stilbene → phenanthrene photocyclization can also be employed for the preparation of benzothiophenophanes, e.g. 43 and 44 , from the respective precursors. (© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2007)
JaViz: A client/server Java profiling tool (2000)

The Java™ programming language, with its portability, object-oriented model, support for multithreading and distributed programming, and garbage collection features, is becoming the language of choice for the development of large-scale distributed applications. Without a suitable performance analysis tool for Java programs, however, it is often difficult to analyze the programs for performance-tuning problems. The profiler included in Sun's Java Development Kit (JDK™) 1.1 does not provide sufficiently detailed trace information to address performance issues in large applications. Also, it does not support the tracing of client/server applications, which are very important for analyzing distributed systems. The JaViz performance analysis tool generates execution traces with sufficient detail to determine program hot spots, including remote method calls, in a distributed Java application program. JaViz provides a graphical display of the program execution tree for the entire distributed applicatio n in the form of a call graph for ease of visualization. A number of features allow users to analyze the execution tree for performance-tuning problems more easily than other Java performance monitoring tools. The usability and functionality of the JaViz tool set is demonstrated by applying it to an example distributed Java application program.
Towards Autonomous Agriculture: Automatic Ground Detection Using Trinocular Stereovision (2012)

Autonomous driving is a challenging problem, particularly when the domain is unstructured, as in an outdoor agricultural setting. Thus, advanced perception systems are primarily required to sense and understand the surrounding environment recognizing artificial and natural structures, topology, vegetation and paths. In this paper, a self-learning framework is proposed to automatically train a ground classifier for scene interpretation and autonomous navigation based on multi-baseline stereovision. The use of rich 3D data is emphasized where the sensor output includes range and color information of the surrounding environment. Two distinct classifiers are presented, one based on geometric data that can detect the broad class of ground and one based on color data that can further segment ground into subclasses. The geometry-based classifier features two main stages: an adaptive training stage and a classification stage. During the training stage, the system automatically learns to associate geometric appearance of 3D stereo-generated data with class labels. Then, it makes predictions based on past observations. It serves as well to provide training labels to the color-based classifier. Once trained, the color-based classifier is able to recognize similar terrain classes in stereo imagery. The system is continuously updated online using the latest stereo readings, thus making it feasible for long range and long duration navigation, over changing environments. Experimental results, obtained with a tractor test platform operating in a rural environment, are presented to validate this approach, showing an average classification precision and recall of 91.0% and 77.3%, respectively.
Management of patients with acute myocardial infarction at five academic medical centers: clinical characteristics, resource utilization, and outcome. (1999)

In this nonrandom sample of academic medical centers, the use of aggressive therapies for acute myocardial infarction was at least as common at non-US as US hospitals. Length of stay was much shorter at the US hospital. Despite these variations in management, evidence for differences in outcomes at one year were not detected.
The role of ultrasound and photoacoustic imaging in laser therapy of cancer (2008)

Laser therapy is an alternative cancer treatment approach when traditional surgery cannot be used to remove small, poorly defined lesions embedded within vital organs. For example, in photothermal laser therapy, a localized temperature increase to cause tumor necrosis is achieved by using a continuous wave laser and molecular targeted and optically tuned photoabsorbers. However, for laser therapy to be successful, it is necessary to identify the presence of photoabsorbers in the tumor prior to therapy, to monitor the spatio-temporal temperature changes during therapy, and, finally, to identify thermal/mechanical damage and tumor destruction after therapy. To guide laser therapy, we developed a combined ultrasound/photoacoustic imaging system and bioconjugated nanoabsorbers. In our approach, ultrasound imaging is utilized to identify the anatomy of the tumor while photoacoustic imaging is used to ensure the presence of targeted nanoparticles before therapy. Both ultrasound and photoacoustic imaging techniques are then used to monitor temperature during therapy, ensuring tumor necrosis and protection of the surrounding healthy tissue. Finally, ultrasound and elasticity imaging is used to confirm thermal damage and cancer destruction. The results of our studies indicate that photoacoustic and ultrasound imaging can be used to effectively guide laser therapy.
Real-Time Doorway Detection and Alignment Determination for Improved Trajectory Generation in Assistive Mobile Robotic Wheelchairs (2013)

Powered wheelchair users may find operation in enclosed environments such as buildings difficult, a fundamental problem exists: wheelchairs are not much narrower than the doorway they wish to pass through. The ability to detect and pass through doorways represents a major current challenge for automated guided wheelchairs. We utilize a simple doorway pattern recognition technique for fast processing in a real-time system for robotic wheelchair users. We are able to show a 96% detection and identification of 5 individual doorways and an 86% recognition rate of 22 separate approach angles and translations. We conclude that pattern recognition using features obtained from simple constrained infrared ranging sensor data binning can be utilized for fast identification of doorways, and important coarse position and approach angle determination, suitable for real-time trajectory adjustment, representing a significant enhancement in this area.
Bioinformatic approaches elucidate a high likelyhood of interaction between miR-182 and the pro-apoptotic gene MTCH2 in breast cancers. (2015)

e12551 Background: Hypoxia is a feature of solid tumours and is associated with malignant progression. Changes in gene-expression have been demonstrated in hypoxic tumours and in vitro systems. Previously, tumour expression patterns were empirically correlated with prognosis but prognostic signatures were derived without reference to the functional roles of their components. This laboratory has developed a seed-clustering approach based on knowledge of hypoxia biology to simplify these signatures. The current work uses this approach to identify new genes regulated by hypoxia and predict prognosis in hypoxic tumours. Methods: Differential gene expression associated with the presence of LDH-A and LDH-B was investigated using bioinformatic approaches to identify metabolic pathways associated with expression of individual isoforms. One promising gene was MTCH2, whose expression followed that of LDH-A. The bioinformatic work was supplemented by immunochemical and RNA studies on tumour cells. Results: Bioinformatics shows an inverse correlation between miR-182 expression and expression of MTCH2 in tumours (152 patients), suggesting possible control of expression by this miRNA. miRNA target prediction tools show a strong probability of interaction. Using cultured human breast cancer cells (ER positive & ER negative) directly, a HIF-1α modulated protein was observed to increase in hypoxia which reacted with anti-MTCH2 antibody. However, knockout studies indicated that the protein varying in these lines was not conventional MTCH2, which decreased under hypoxia. Attempts to identify the immunoreactive protein proved inconclusive. Measurement of miR-182 indicated that its level rose under hypoxia in the two cell lines studied. Conclusions: Bioinformatic analysis, using RNA extracted from primary tumours, identified MTCH2 as a hypoxia-induced protein. This observation could not be directly transferred to in vitro cell lines although an MTCH2-like protein is induced by hypoxia in these lines. In both primary tumours and cell lines, there was an inverse relation between conventional MTCH2 and miR-182 levels. This may have implications for therapeutic use of miRNA.
Apolipoprotein E genotype and the association between C‐reactive protein and postoperative delirium: Importance of gene‐protein interactions (2019)

Our findings raise the possibility that APOE ε4 carrier status may modify the relationship between postoperative day 2 CRP levels and postoperative delirium.
Mitochondrial function and oxidative stress markers in higher-frequency episodic migraine (2020)

Abstract Introduction Increasing evidence points towards the role of mitochondrial functioning, energy metabolism, and oxidative stress in migraine. However not all previous research has been conclusive and some mitochondrial function / oxidative stress markers have not yet been examined. Methods To this end, alpha-lipoic acid (ALA), total thiols, total plasma antioxidant capacity (TAC), lipid peroxide (PerOx), oxidised LDL (oxLDL), HbA1c and lactate were determined in the serum of 32 higher frequency episodic migraineurs (5-14 migraine days/ months, 19 with aura, 28 females) in this cross-sectional study. Results The majority of patients had abnormally low ALA and lactate levels (87.5% and 78.1%, respectively). 46.9% of the patients had abnormally high PerOx values, while for thiols and TAC over one third of patients had abnormally low values (31.2% and 37.5%, respectively). 21.9% of patients had abnormally low HbA1c and none had an HbA1c level above 5.6%. oxLDL was normal in all but one patient. Discussion This study provides further evidence for a role of oxidative stress and altered metabolism in migraine pathophysiology, which might represent a suitable therapeutic target. ALA, being too low in almost 90% of patients, might represent a potential biomarker for migraine. Further research is needed to replicate these results, in particular a comparison with a control group. This study is part of the trial registration: ClinicalTrials.gov: NCT03132233, registered on 27.04.2017, https://clinicaltrials.gov/ct2/show/NCT03132233