gebhart/patrepeval huggingface dataset:
Resistance to what, does it matter? How do we study it? (2008)

The importance of platelets and thrombosis in the pathophysiology of acute ischaemic coronary syndromes has been well appreciated. This information has formed the backbone of the guidelines on both sides of the Atlantic that patients with acute as well as chronic coronary artery disease be treated with aspirin as a long-term strategy of care. While the specific dosage schedule may vary, aspirin treatment remains a Class I indication.1 Increasingly, adherence to this as well as other guidelines is a measure of quality of care.

The issue of platelet function and thrombosis has become more complicated in the era of stent-based percutaneous coronary intervention (PCI);2–4 this is a particular issue regarding the problem of stent thrombosis, a subject which has attracted tremendous scientific, lay press, and patient as well as regulatory interest.

This interest has been stimulated by several factors:5,6 (i) stent placement is the procedure of choice for … 

*Corresponding author. Tel: +1 507 255 2504, Fax: +1 507 255 2550, Email: dholmes{at}mayo.edu
A mighty wind (2009)

Developments in the world of wind continue to happen at record speed. The world as a whole is in the midst of grappling with an epochal transition from a system dominated by fossil and nuclear fuel to one that relies much more heavily on renewable energy. No technology breakthroughs are required for the United States to achieve the scenario of 20% of electricity from wind by 2030. Instead, many evolutionary steps executed with technical skill, which can cumulatively result in a 30-40% improvement in the cost effectiveness of wind technology over the next few decades, are expected to occur.
Surface activation of medical grade polyurethane for the covalent immobilization of an anti-adhesive biopolymeric coating (2021)

Hospital-acquired infections are still a major concern worldwide, being frequently related to bacterial biofilm formation on medical devices, and thus difficult to eradicate with conventional antimicrobial treatments. Therefore, infection-preventive solutions based on natural polymers are being investigated. Recently, a marine cyanobacterium-derived polymeric coating (CyanoCoating) has demonstrated great anti-adhesive potential when immobilized onto gold model substrates. In this work, we took this technology a step closer to an industrial application by covalently immobilizing CyanoCoating onto medical grade polyurethane (PU). This immobilization was developed through the introduction of linkable moieties onto a PU inert surface using different pre-treatments. Besides the application of the polydopamine (pDA) linker layer, other processes frequently found in industrial settings, such as atmospheric plasma (using O2 or N2 as reactive gases) and ozone surface activations, were evaluated. From all the pre-treatments tested, the ozone activation was the most promising since the obtained coating not only revealed a homogeneous distribution, but also significantly reduced the adhesion of two relevant etiological bacteria in static conditions (the Gram-positive Staphylococcus aureus and the Gram-negative Escherichia coli). Moreover, it also impaired E. coli biofilm formation under simulated urinary tract dynamic conditions, reinforcing the potential of CyanoCoating as an antibiotic-free alternative to mitigate medical device-associated infections, particularly in the urinary tract.
Olaparib‐Based Photoaffinity Probes for PARP‐1 Detection in Living Cells (2020)

The poly-ADP-ribose polymerase (PARP) is a protein from the family of ADP-ribosyltransferases that catalyzes polyadenosine diphosphate ribose (ADPR) formation in order to attract the DNA repair machinery to sites of DNA damage. The inhibition of PARP activity by olaparib can cause cell death, which is of clinical relevance in some tumor types. This demonstrates that quantification of PARP activity in the context of living cells is of great importance. In this work, we present the design, synthesis and biological evaluation of photo-activatable affinity probes inspired by the olaparib molecule that are equipped with a diazirine for covalent attachment upon activation by UV light and a ligation handle for the addition of a reporter group of choice. SDS-PAGE, western blotting and label-free LC-MS/MS quantification analysis show that the probes target the PARP-1 protein and are selectively outcompeted by olaparib; this suggests that they bind in the same enzymatic pocket. Proteomics data are available via ProteomeXchange with identifier PXD018661.
Peptidoglycan in walls of Butyribacterium rettgeri (1969)

peer reviewed
O ciclo «natureza e ecologia» na literatura de cordel brasileira (2012)

Investigamos neste artigo o pensamento naturista e ecológico do cordel brasileiro, que, relacionando áreas como a natureza, o ambiente, a religião, a técnica, a ciência, o ensino, a cidadania e a denúncia de desigualdades e injustiças contra pessoas, seres vivos e não vivos, configurou já um ciclo a que a crítica literária não tem prestado a devida atenção.
Ion Beam Surface Engineering for Highly Active Nanocatalysts (2015)

Interface science is at the forefront in the development of new materials for advanced technological applications. In particular, surface properties strongly influence catalysis which is essentially a surface phenomenon. One of the novel applications of ion beam irradiation includes the modification of the catalytic activity of solid catalysts. In this study we evaluated the effect of ion irradiation on the catalytic properties of Ce0.7Zr0.3O2 and the supported noble metal catalyst Pt/Ce0.7Zr0.3O2, which plays an important role in automotive exhaust control applications, among others. The effect on the catalytic properties is discussed from Temperature Programmed Oxidation (TPO) and Reduction (TPR) measurement, together with the results of microstructural (TEM) and IR spectrometric analyses.
PCR based identification and discrimination of agents of mucormycosis and aspergillosis in paraffin wax embedded tissue (2005)

The two seminested PCR assays described here can support a histopathological diagnosis of mucormycosis or aspergillosis, and can identify the infective agent, thereby optimising antifungal treatment.
P393miR-1: a link between SERCA2a and the Beta-Adrenoceptor in the failing heart? (2014)

Purpose: Changes to the cellular expression of numerous microRNAs (miRs) have been implicated in disease development. MiR-1 expression is down-regulated in human heart failure (HF) and our in vivo rat HF model, we aimed to further understand its significance in HF. We previously showed that miR-1 expression was restored by in vitro adenovirus-mediated restoration of SERCA2a in adult rat HF cardiomyocytes, in response to diastolic calcium changes. Methods: Adult rats that underwent surgical ligation of the left anterior descending coronary artery to induce myocardial infarction (.30%) were maintained 16-20 weeks until HF developed. Cardiomyocytes were isolated for in vitro transfection by lipofection with miR-1 constructs followed by 48 hours culture. We examined cardiomyocyte calcium handling, contractile function, and gene expression analysis by quantitative RT-PCR. Results: The contractile beta-adrenoceptor (bAR) response to isoprenaline was depressed in cardiomyocytes from HF rats, but was restored in HF cardiomyocytes by increasing miR-1 expression (Figure Selective pharmacological inhibition revealed that SERCA2a function was unchanged, and that it was an elevated b2AR response that had improved cell shortening in the HF cardiomyocytes to levels comparable to healthy. b2AR expression was unchanged after pre miR-1 treatment, implying it is the functional signalling of the receptor that is influenced by miR-1. Conclusion: Restoration of miR-1 reverses HF-induced bAR desensitisation. We suggest that the SERCA2a down-regulation and consequent increase of diastolic calcium may signal through miR-1 reduction to produce bAR signalling alterations in HF.
Resource management in agent-based distributed environments (2003)

This paper presents an agent-based architecture for optimally managing resources in distributed environments. The agent-based approach allows for maximal autonomy in agent negotiation and decision-making. A three-layer architecture is proposed, consisting of the user, agency and application domain layers. Agencies correspond to enterprise functional units, and agents are associated with agencies. A formal model of resources and constraints is presented, and it is shown that, under certain assumptions, optimal resource decompositions and allocations can be achieved. A distributed protocol is developed for agencies and agents to negotiate and exchange resources autonomously, while still satisfying both local and global constraints.
P53-independent apoptosis: a mechanism of radiation-induced cell death of glioblastoma cells. (2006)

Apoptosis is an important component of the lethal effect of ionizing radiation on glioblastoma cells and does not require wild-type p53 expression. Glioblastoma expressing wild-type p53 exhibited no apoptosis, even after high radiation doses, but rather underwent a prolonged G1 arrest. The observation of p53-independent apoptosis and p53-dependent Gi arrest in glioblastoma cells have important radiobiologic and clinical implications.
ChemInform Abstract: Directed ortho‐Lithiation of Chloroquinolines. Application to the Synthesis of 2,3‐Disubstituted Quinolines. (1990)

Abstract 2‐Chloroquinoline (I) is lithiated by LDA at the more acidic C‐3 position; subsequent reaction with electrophiles, e.g. (IV), gives derivatives such as (V).
ChemInform Abstract: Connection Between Metalation of Azines and Diazines and Cross‐ Coupling Strategies for the Synthesis of Natural and Biologically Active Molecules (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The spread of true and false news online (2018)

We investigated the differential diffusion of all of the verified true and false news stories distributed on Twitter from 2006 to 2017. The data comprise ~126,000 stories tweeted by ~3 million people more than 4.5 million times. We classified news as true or false using information from six independent fact-checking organizations that exhibited 95 to 98% agreement on the classifications. Falsehood diffused significantly farther, faster, deeper, and more broadly than the truth in all categories of information, and the effects were more pronounced for false political news than for false news about terrorism, natural disasters, science, urban legends, or financial information. We found that false news was more novel than true news, which suggests that people were more likely to share novel information. Whereas false stories inspired fear, disgust, and surprise in replies, true stories inspired anticipation, sadness, joy, and trust. Contrary to conventional wisdom, robots accelerated the spread of true and false news at the same rate, implying that false news spreads more than the truth because humans, not robots, are more likely to spread it.
The HITS Icon Editor: the specification of graphic behavior without coding (2002)

The authors describe the Icon Editor, a platform for exploring the construction of dynamic graphical icons and techniques for relating those entities to an application. Discussed is the specification of dynamic icons for use in an interface. Considered are a conceptualization for building appearance and behavior and a prototype system. The authors generalize the notion of tapping, the process of relating an interface object to its application. Tapping supports two-way communication between the interface and the application. The icons can monitor their application states and modify them via mouse input. This representation often involves a transformation of values between application and graphical states. The authors discuss the theory, current implementation, examples of icon construction, and future directions. The aim of the present work is development of a framework supporting knowledge-based tools to aid in building interfaces without coding.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Precise Quantification of Leaf Spot in Saintpaulia by Image Analysis with a Transmitted Light. (1996)

Quantification of leaf spot (leaf damage with yellow spot) in Saintpaulia (Saintpaulia ionantha H. Wendl. cv. Ritali) was conducted by using an image analysis technique. Clear images without distortions or shadows were acquired by using a transmitted light from underneath the leaf. Quantification by the image analysis has very high correlation with that estimated by weighing the replicas of photograph. Furthermore, images analyzed by using an image editing software corresponded very well with the micrograph photographed under a fluorescence microscopy. These results indicate that the proper use of the transmitted light can provide precise quantification of leaf damage, even if it is characterized by a very complex pattern as leaf spot in Saintpaulia.
Large mitochondrial DNA differences between morphologically similar Penaeid shrimp. (1991)

Sequencing of mtDNA fragments amplified with the polymerase chain reaction is used to examine genetic differences between species of Penaeid shrimp. The data show surprisingly high genetic differences among morphologically and ecologically similar species. Differences at silent sites between subgenera of shrimp are larger than between families of mammals. Between genera, Penaeid shrimp are more divergent than some orders of mammals. Because taxonomic differences are defined on morphological grounds, these results imply that the rates of molecular versus morphological evolution in shrimp are different than in mammals. Perhaps mtDNA evolution is accelerated in shrimp, or perhaps stabilizing selection over a long time period has reduced rates of morphological change. For Penaeid shrimp, morphological similarity can mask large genetic differences.
Targeting IL-1 in Sjögren's syndrome (2013)

Introduction: IL-1 plays key roles in the biological functions of various cells. In particular, many roles of IL-1 in the immune system have been discovered by numerous studies. This review focuses on the association of IL-1 with the pathogenesis of autoimmunity. Areas covered: An overview of the biological functions of the IL-1 family and the IL-1 receptors (IL-1Rs), including the maintenance of systemic or local homeostasis, and the signaling pathway through IL-1/IL-1R in various immune systems are described. Several functions of IL-1 in the pathogenesis of Sjögren's syndrome (SS) have been demonstrated with a focus on the immune responses and target tissues in SS. In addition to the role of IL-1 in the immune responses in SS, the function of IL-1 in ocular mucosa lesions in SS has been described. Lastly, there is an overview of possible therapeutic strategies for IL-1 inhibition in SS. Expert opinion: IL-1 plays critical roles in the onset and development of SS by controlling systemic or local immune responses and maintaining the survival and mucosal defense of target epithelial cells. The inhibition of the pathogenic functions of IL-1 may be beneficial for treating SS.
Ground Reflection Removal in Compressive Sensing Ground Penetrating Radars (2011)

Recent results in compressive sensing (CS)-based subsurface imaging showed that, if the target space is sparse, it can be reconstructed with many fewer number of measurements from a stepped frequency ground penetrating radar (GPR). One of the problems in this CS subsurface imaging is the surface reflections. Previous work dealed with surface reflections using a model dictionary generated from the target space excluding specifically the near surface region. While this works fine for some applications, it might lack the imaging of near surface targets. Removing the surface reflections with standard methods is not directly applicable since only very few and random measurements in the frequency domain are taken. This letter provides a simple surface reflection method using compressive measurements, that can be used for nonplanar surfaces. It is observed in both simulated and experimental GPR data that the CS-based imaging method is more robust and can find shallow targets using the surface-reflection-removed data.
Measurement of the Earth's Rotation Using a Chip-Based Brillouin Laser Gyroscope (2019)

We report a chip-based Brillouin laser gyroscope with 0.068° / h angular random walk and 3.6° /h bias stability. The device can resolve sinusoidal rotations with amplitude as low as 5° /h and is also used to measure the Earth's rotation. © 2019 The Author(s)
Nature of seismic control force in acceleration feedback (2012)

Active control methods have been applied to numerous civil structures in recent years. A significant amount of the research on active control methods has been based on full-state feedback using the linear quadratic regulator (LQR) control algorithm; because measurement of the full state (i.e., the displacements and velocities of all DOFs) is difficult, such algorithms are impractical in full-scale implementations. Output feedback strategies based on measured acceleration at a limited number of points has been proposed and validated. However, a thorough understanding of the dissipative nature of the associated control forces and the way in which these forces protect the structure have been elusive. This paper considers the hysteric behavior of the control forces produced by the widely employed linear quadratic Gaussian (LQG)-based acceleration feedback control strategies and explores parallels with the pseudo-negative stiffness (PNS) semi-active damping systems. Numerical simulation studies carried out on one-story and three-story buildings with active bracing show that the LQG-based algorithms are quite versatile and can produce controllers with a variety of behaviors, including the PNS, depending upon the control objectives chosen. Copyright © 2012 John Wiley & Sons, Ltd.
Serological and Genetical Studies on a Platelet Antigen (Zw) (1959)

Summary A strong platelet agglutinin was found in the serum of a patient who received several blood transfusions; patient was suffering from a severe thrombopenia. It is most likely that the platelet antibody developed after blood transfusion and was probably the cause of an uncommon reaction. The serological properties of the antibody, preliminarily named «anti‐Zw» are discussed. Out of 287 platelet suspensions of unrelated subjects 280 were agglutinated by the serum anti‐Zw, i.e. 97.6%. The hereditary character of the corresponding antigen was established by analysis of three families. Résumé Une forte agglutinine antithrombocytaire a été trouvée dans le sérum d'un malade qui avait regu plusieurs transfusions de sang; le malade présentait une thrombopénie grave. Il paraît trbs probable que I'anticorps ait été produit à la suite des transfusions et qu'il fut la cause d'une réaction assez rare. Les propriétés sérologiques de l'anticorps, appelé provisoirement «anti‐Zw», sont discutées. De 287 suspensions de thrombocytes provenant de sujets non apparentés, 280, c'est‐à‐dire 97,6%, furent agglutinées par le serum anti‐Zw. Le caractère héréditaire de l'antigène ainsi reconnu put être établi par l'analyse de trois familles. Zusammenfassung Im Serum einer Patientin, die an einer schweren Thrombopenie litt und welche mehrere Bluttransfusionen erhalten hatte, wurde ein kräftiges Plättchenagglutinin gefunden. Dieses Plättchenagglutinin entwickelte sich offenbar im Anschluß an die Transfusionen. Anläßlich der letzten Transfusion wurde eine ungewöhnliche Reaktion beobachtet, die wahrscheinlich auf der Wirkung dieses Antikörpers be‐ruhte. Die serologischen Eigenschaften dieses, vorläufig als «Anti‐Zw» bezeichneten Antikörpers, werden diskutiert. 280 von insgesamt 287 Plättchensuspensionen, die von nicht verwandten Individuen stammten, werden durch dieses Serum agglutiniert. Die Häufigkeit des Zw‐Antigens beträgt in der niederländischen Bevölkerung 97,6%. An Hand der Untersuchung von drei Familien gelang es, zu zeigen, daß dieses Antigen dominant vererbt wird.
Spatial Prediction Under Location Uncertainty in Cellular Networks (2016)

Coverage optimization is an important process for the operator, as it is a crucial prerequisite toward offering a satisfactory quality of service to the end users. The first step of this process is coverage prediction, which can be performed by interpolating geo-located measurements reported to the network by mobile user's equipments. In the previous works, we proposed a low complexity coverage prediction algorithm based on the adaptation of the geo-statistics fixed rank kriging (FRK) algorithm. We supposed that the geo-location information reported with the radio measurements was perfect, which is not the case in reality. In this paper, we study the impact of location uncertainty on the coverage prediction accuracy and we extend the previously proposed algorithm to include geo-location error in the prediction model. We validate the proposed algorithm using both simulated and real-field measurements. The FRK is extended to take into account that the location uncertainty proves to enhance the prediction accuracy while keeping a reasonable computational complexity.
OC71 SURGICAL TREATMENT FOR ISOLATED TRICUSPID VALVE INFECTIVE ENDOCARDITIS. 25-YEAR RESULTS (2018)

Background and Aim: Right-sided infective endocarditis (RSIE) is less common than left-sided infective endocarditis (IE), encompassing only 5–10% of cases, 90% of RSIE involves the tricuspid valve (TV). We sought to evaluate early and late mortality of patients with isolated TVIE. Methods: The National Registry for Surgical Treatment of Valve and Prosthesis Infective Endocarditis included 4084 patients from February 1999 to January 2018. From 1983 to 2018, isolated TVIE was surgically treated in 157 (3.8%). Mean age was 47 ± 16 (15–86 years); 25% were females 142 (90%) native tricuspid regurgitation; 7 (5%) native stenosis-insufficiency and 8 (5%) tricuspid prosthesis endocarditis (TPIE). 38% due to IVDU; 21% due to PMK/ICD leads; 1% due to vascular access for dialysis; in the remaining cases, the cause was unknown Staphilococcus aureus was the most common germ (45%); The primary end-point was long-term survival freedom from recurrence; Results: 77 (49%) underwent TV repair, 72 (46%) TV replacement and 8 (5%) TV prosthesis replacement. Early mortality was 11% (17 patients); Expected mortality according to EndoSCORE was 12%; age (OR 1.06) and redo (OR 6.64) were risk factors. Median follow up was 229 months (172–286) Late deaths were 31;Recurrences were 4 (all dead). Survival at 10, 20 and 25-year were 66%, 60% and 44%, respectively. Risk factors were age (HR 1.06), fungine TVIE (HR 4.2), IVDU HR 4.90), redo (HR 4.4) and presence of leads (HR 3.0). No difference was found between repair and replacement (Figure) Conclusions: Patients with isolated TVIE undergoing surgical treatment show good early and late outcome.
Theory of a Class of Planar Frequency-Independent Omnidirectional Traveling-Wave Antennas (2006)

The theory for a new class of planar frequency-independent omnidirectional antenna has been developed and found to be consistent with measured data, with better agreement than many of those obtained by brute-force numerical computation. More importantly, the theory is useful for design and synthesis because of its simple closed-form solution, which has direct and close relevance to the physical parameters and performance of the planar frequency-independent omnidirectional antenna. A building block for the theory is that for the annular slots, which has some errors in the literature. These errors in the equations and figures were also discussed and corrected in this paper