gebhart/patrepeval huggingface dataset:
Cluster Analysis of Historical and Modern Hard Red Spring Wheat Cultivars Based on Parentage and HPLC Analysis of Gluten‐Forming Proteins (2017)

Thirty hard red spring (HRS) wheat cultivars released between 1910 and 2013 were analyzed to determine how they cluster in terms of parentage and HPLC analysis of gliadins and unreduced proteins. Markers for reduced height genes were assessed to determine associations between semidwarfism and protein composition, as well as quality characteristics. In terms of parentage, the clusters formed were grouped according to release year and semidwarfism. Farinograph development time and stability showed significant ( P ≤ 0.05) differences between clusters, indicating improvement of mixing characteristics over time. Flour ash content was significantly different ( P ≤ 0.05) between clusters, indicating improved milling quality. The clusters based on the gliadin reverse‐phase HPLC peak binary data did not group cultivars according to release year and the semidwarf characteristic. However, cultivars were grouped according to year in the absorbance area based dendrogram. The clusters based on absorbance area of size‐exclusion HPLC showed significant ( P ≤ 0.05) differences for release year, the semidwarf characteristic, and farinograph stability. Overall, the results indicate that the introduction of reduced height genes accompanied the improvements of dough mixing and breadmaking quality characteristics, without altering the composition of gliadin proteins over the last 100 years of HRS wheat breeding.
Preparation and photochemistry of pyrimidine nucleoside sulfonium ylides (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and photochemistry of pyrimidine nucleoside sulfonium ylidesBernhard Witkop and Takehisa KuniedaCite this: J. Am. Chem. Soc. 1971, 93, 14, 3487–3493Publication Date (Print):July 1, 1971Publication History Published online1 May 2002Published inissue 1 July 1971https://pubs.acs.org/doi/10.1021/ja00743a032https://doi.org/10.1021/ja00743a032research-articleACS PublicationsRequest reuse permissionsArticle Views310Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Field Test Results from the Sandia SMART Rotor (2013)

*† ‡ Sandia National Laboratories has concluded field testing of its wind turbine rotor equipped with trailing-edge flaps. The blade design, fabrication, and integration which have been described in previous papers are briefly reviewed and then a portion of the data is presented and analyzed. Time delays observed in the time-averaged response to stepwise flap motions are consistent with the expected time scales of the structural and aerodynamic phenomena involved. Control authority of the flaps is clearly seen in the blade strain data and in hub-mounted video of the blade tip movement.
Anti-inflammatory Agents and Allergen-induced β2-Receptor Dysfunction in Isolated Human Bronchi (1998)

Antigen challenge causes beta2-adrenoceptor dysfunction in sensitized human bronchi (Am. J. Respir. Crit. Care Med. 1997;155:1230-1234). This study investigated whether the dysfunction can be prevented by anti-inflammatory agents. Human bronchial rings (2 to 4 mm) from surgery were passively sensitized to house dust mite and challenged (1) with allergen only, (2) with allergen plus indomethacin (10(-)5 M), (3) with allergen plus nedocromil sodium (10(-)7 M to 10(-)5 M), (4) with allergen plus the H1-receptor antagonist cetirizine (10(-)7 M to 10(-)5 M), and (5) with allergen plus the peptido-leukotriene receptor antagonist iralukast (10(-)7 M to 10(-)5 M). Rings were first contracted with 10(-)6 M carbachol and then relaxed with salbutamol (10(-)9 M to 10(-)4 M). The concentration-relaxation curve to salbutamol was shifted significantly to the right in the rings challenged with allergen only compared with control rings. In the rings challenged with allergen plus nedocromil sodium (10(-)6 M and 10(-)5 M) or iralukast (10(-)6 M and 10(-)5 M) the concentration-relaxation curves to salbutamol were significantly shifted to the left compared with rings challenged in saline alone, suggesting a protective effect against beta2-adrenoceptor dysfunction. Neither allergen plus cetirizine nor allergen plus indomethacin shifted significantly the concentration-relaxation curves to salbutamol compared with rings challenged in saline alone. We conclude that the release of peptido-leukotrienes may play a significant role in causing the allergen-induced beta2-receptor dysfunction in passively sensitized human bronchi.
Tensile impact properties of thermoplastics (1964)

Abstract The impact strength of a thermoplastic is shown to be a strong function of several variables. Among these are type of molding, molding conditions, molecular orientation, test temperature, and notches. Particularly significant is a maximum in the response of impact strength to molding temperature. The tensile impact test was used as a tool for these determinations.
Cotton growth in UNR systems (2003)

58 any benefits that UNR may confer (Figure 1). Measuring the growth of UNR cotton in comparison with conventionally spaced cotton without the confounding effects of different approaches to crop agronomy is the first step in gaining this understanding. Ultimately though, to optimise the UNR cropping system may mean developing a complete agronomic package that may differ from current agronomic practices in a number of ways.&#13;\n&#13;\nEarly and frequent use of Pix is often considered as part of a UNR systems package. To date most trials in Australia comparing UNR to conventionally spaced systems have included differences in Pix applications—confounding comparisons that may identify any advantages of UNR for earliness and yield. As it is the aim of the project to understand the crop physiological factors that drive yield and maturity in the UNR system, none of the trials so far have had any Pix applications.
Reentrant Phenomenon in Disc-Like Liquid Crystal (1981)

Abstract Several Hexa-n-alkanoates of truxene with long alkyl chains exhibit, above and below a ND nematic phase, an hexagonal columnar phase. It is probably the first example of a reentrant phenomenon for pure disc-like liquid crystals at atmospheric pressure.
Integral Sampler and Polynomial Multiplication Architecture for Lattice-based Cryptography (2022)

With the surge of the powerful quantum computer, lattice-based cryptography proliferated the latest cryptography hardware implementation due to its resistance against quantum computers. Among the computational blocks of lattice-based cryptography, the random errors produced by the sampler play a key role in ensuring the security of these schemes. This paper proposes an integral architecture for the sampler, which can reduce the overall resource consumption by reusing the multipliers and adders within the modular polynomial computation. For instance, our experimental results show that the proposed design can effectively reduce the discrete Ziggurat sampling method in DSP usage.
Photon Counting OTDR: Advantages and Limitations (2010)

In this paper, we provide a detailed insight into photon-counting optical time-domain reflectometer (¿-OTDR) operation, ranging from Geiger-mode operation of avalanche photodiodes (APD), analysis of different APD bias schemes, to the discussion of OTDR perspectives. Our results demonstrate that an InGaAs/InP APD-based ¿-OTDR has the potential of outperforming the dynamic range of a conventional state-of-the-art OTDR by 10 dB, as well as the two-point resolution by a factor of 20. Considering the trace acquisition speed of ¿-OTDRs, we find that a combination of rapid gating for high photon flux and free running mode for low photon flux is the most efficient solution. Concerning dead zones, our results are less promising. Without additional measures, e.g., an optical shutter, the photon counting approach is not competitive.
Routine Hospital Use of a New Commercial Whole Blood Interferon-γ Assay for the Diagnosis of Tuberculosis Infection (2005)

The QFT-Gold test is feasible in routine hospital use for the diagnosis of tuberculosis infection. As with the TST, immunosuppression may negatively affect the test's performance, with a significant rate of indeterminate results in the most vulnerable population.
An interconnect-centric design flow for nanometer technologies (2001)

As the integrated circuits (ICs) are scaled into nanometer dimensions and operate in gigahertz frequencies, interconnects have become critical in determining system performance and reliability. This paper presents the ongoing research effort at UCLA in developing an interconnect-centric design flow, including interconnect planning, interconnect synthesis, and interconnect layout, which allows interconnect design and optimization to be properly considered at every level of the design process. Efficient interconnecter performance estimation models and tools at various levels are also developed to support such an interconnect-centric design flow.
Learning of local predictable representations in partially learnable environments (2015)

PROPRE is a generic and cortically inspired framework that provides online input/output relationship learning. The input data flow is projected on a self-organizing map that provides an internal representation of the current stimulus. From this representation, the system predicts the value of the output target. A predictability measure, based on the monitoring of the prediction quality, modulates the projection learning so that to favor learning of representations that are helpful to predict the output. In this article, we study PROPRE when the input/output relationship is only defined in a small subspace of the input space, that we define as a partially learnable environment. This problem, which is not typical of the machine learning field, is however crucial for the robotic developmental field. Indeed, robots face high dimensional sensory-motor environments where large areas of these sensory-motor spaces are not learnable since a motor action cannot have a consequence on every perception each time. We show that the use of the predictability measure in PROPRE leads to an autonomous gathering of local representations where the input data are related to the output value, thus providing good classification performance as the system will learn the input/output function only where it is defined.
Role of microRNA deregulation in the pathogenesis of diffuse large B-cell lymphoma (DLBCL) (2013)

MicroRNAs (miRNAs) are small endogenous RNA molecules that regulate gene expression at the post-transcriptional level through its sequence complementation with target mRNAs. An individual miRNA species can simultaneously influence the expression of multiple genes and conversely, several miRNAs can synchronously control expression of specific gene product mRNA levels. Thus, miRNAs expression in cells has to be precisely regulated and alterations in miRNA levels may cause an aberrant expression of genes involved in oncogenic pathways and consequently result in cancer development. Indeed, miRNA expression is often deregulated in many cancers, including B-cell lymphomas. Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous group of B-cell lymphomas with different genetic backgrounds, morphologic features, and responses to therapy. Over the past decade, miRNAs emerged as a new tool for understanding DLBCL biology, and promising candidate molecular markers in DLBCL classification and treatment. In this review, we will focus on miRNAs aberrantly expressed in DLBCL and discuss the putative mechanisms of this deregulation. Additionally, we will summarize miRNAs' involvement in the identification of DLBCL subgroups, and their potential role as diagnostic/prognostic biomarkers as well as specific therapeutic targets for DLBCL.
Effects of lactobacilli on yeast-catalyzed ethanol fermentations (1997)

Normal-gravity (22 to 24 degrees Plato) wheat mashes were inoculated with five industrially important strains of lactobacilli at approximately 10(5), approximately 10(6), approximately 10(7), approximately 10(8), and approximately 10(9) CFU/ml in order to study the effects of the lactobacilli on yeast growth and ethanol productivity. Lactobacillus plantarum, Lactobacillus paracasei, Lactobacillus #3, Lactobacillus rhamnosus, and Lactobacillus fermentum were used. Controls with yeast cells but no bacterial inoculation and additional treatments with bacteria alone inoculated at approximately 10(7) CFU/ml of mash were included. Decreased ethanol yields were due to the diversion of carbohydrates for bacterial growth and the production of lactic acid. As higher numbers of the bacteria were produced (depending on the strain), 1 to 1.5% (wt/vol) lactic acid resulted in the case of homofermentative organisms. L. fermentum, a heterofermentative organism, produced only 0.5% (wt/vol) lactic acid. When L. plantarum, L. rhamnosus, and L. fermentum were inoculated at approximately 10(6) CFU/ml, an approximately 2% decrease in the final ethanol concentration was observed. Smaller initial numbers (only 10(5) CFU/ml) of L. paracasei or Lactobacillus #3 were sufficient to cause more than 2% decreases in the final ethanol concentrations measured compared to the control. Such effects after an inoculation of only 10(5) CFU/ml may have been due to the higher tolerance to ethanol of the latter two bacteria, to the more rapid adaptation (shorter lag phase) of these two industrial organisms to fermentation conditions, and/or to their more rapid growth and metabolism. When up to 10(9) CFU of bacteria/ml was present in mash, approximately 3.8 to 7.6% reductions in ethanol concentration occurred depending on the strain. Production of lactic acid and a suspected competition with yeast cells for essential growth factors in the fermenting medium were the major reasons for reductions in yeast growth and final ethanol yield when lactic acid bacteria were present.
Performance of lithium niobate polarisation convertor/tunable filter (1988)

We describe detailed measurements of the performance of an electro-optically tunable lithium niobate polarisation convertor. Operation of the device is described with reference to the Poincaré sphere, and plots of effective birefringence as a function of electrode voltages are provided.
Development of a New HPLC Method for Determination of Papaverine in Presence of Its Photooxidation Products (2010)

A new HPLC method was developed for determination of papaverine in a papaverine naturally photooxidized solution using a Duet C18/SCX column. The mobile phase used was a mixture of phosphate buffer (pH = 3.80) and acetonitrile in 40:60 ratio. The compounds identified were: papaverinol, papaveraldine, papaverine, and pyrrocolonium ion. Very good resolutions, peak shapes, and asymmetries were obtained. An ion exchange experiment was developed in order to identify and separate the pyrrocolonium ion. This was retained completely by a cation exchange resin in its Na+ form, while papaverine, papaverinol, and papaveraldine were retained more or less, due to a retention explained by a combined ion exchange-solvent extraction mechanism. Voltammetric studies showed that natural photooxidation of papaverine occurs in three irreversible steps and yields to stable compounds in solution.
Role of Glycogen Synthase Kinase-3α in Insulin Action in Cultured Human Skeletal Muscle Cells (2007)

An association between glycogen synthase kinase-3 (GSK3) in skeletal muscle and insulin resistance has been demonstrated in type 2 diabetic patients. In addition, inhibition of GSK3 improves insulin action. The aim of the present study was to elucidate the role of the alpha-isoform of GSK3 in insulin resistance in human skeletal muscle cells from nondiabetic subjects maintained in culture. Transfection of muscle cells with specific antisense oligonucleotides resulted in a 30-50% decrease of GSK3alpha protein expression (P < 0.05). Whereas neither the basal fractional velocity of glycogen synthase (GS FV) (an indicator of the activation state of the enzyme) nor glucose uptake (GU) were altered, reducing GSK3alpha expression resulted in increases in insulin stimulation of both GS FV and GU. GSK3alpha overexpression (60-100% increase over control) did not alter basal GS FV or GU but impaired insulin stimulation of both responses. Knockdown of GSK alpha also led to an increase in insulin receptor substrate-1 protein expression but did not alter insulin stimulation of pS473-Akt phosphorylation. However, GSK3alpha overexpression impaired insulin action on pS473-Akt. In summary, we concluded the following: 1) modulation of GSK3alpha expression has no effect on basal GU and glycogen synthase activities; 2) reduction of GSK3alpha expression results in improvements in insulin action; and 3) elevation of GSK3alpha in human skeletal muscle cells can induce insulin resistance for several responses. We conclude that GSK3alpha is an important regulator of muscle insulin action.
Distortion Compensation for Generalized Stereoscopic Particle Image Velocimetry (1997)

Optical distortion caused by inaccurate optical alignment, lens nonlinearity, and/or refraction by optical windows, fluid interfaces, and other optical elements of an experiment cause inaccuracy by introducing variable magnification. Since fractional changes in the magnification have a one-to-one effect on the accuracy of measuring the velocity, it is important to compensate for such distortions. A general experimental calibration procedure is described which determines the magnification matrix of a distorted imaging system, and an algorithm is presented to compute accurate velocity field displacements from measurements of distorted PIV images. These procedures form a basis for generalized stereoscopic PIV procedures which permit easy electronic registration of multiple cameras and accurate recombination of stereoscopic displacement fields to obtain the three-dimensional velocity vector field.
Abstract 2456: Transcriptional signatures of stem cell phenotypes in normal and clonal hematopoiesis (2023)

Abstract Clonal hematopoiesis (CH) is an age-related clonal expansion of hematopoietic stem cells (HSCs). Factors that shape the progression of CH are only beginning to be characterized. HSCs are a heterogeneous population of cells with distinct clonal outputs over time, which are hypothesized to be largely scripted in epigenetic and transcriptional cell state. Molecular properties of HSC states that mediate clonal behaviors of two major driver mutations in CH - DNMT3A and TET2 - represent potential therapeutical targets. Recent studies have identified the landscape of human CH mutant cells compared to non-mutated ones. However, the notion of a specific molecular target identified in CH cells associated with selective advantage or predisposition for subsequent transformation requires a formal validation by longitudinal studies. To uncover molecular underpinnings of CH-driven clonal phenotypes in human HSCs in vivo, we combined clonal analysis using heritable expressed DNA barcodes with single-cell transcriptomics using transplant in immunodeficient mice. We developed a statistical approach to associate transcriptional differences of HSCs with the clone phenotypes, such as size and HSC density, across more than a hundred of detected clones. It revealed robust transcriptional signatures underlying clone size and HSC density, which are largely complementary to transcriptional programs activated in TET2 and DNMT3A mutant HSCs. Of note, the clone size and density of HSCs in the clone tend to be uncoupled and associated with distinct transcriptional processes. Citation Format: Ruslan Soldatov, Giulia Schiroli, Peter Kharchenko, David Scadden. Transcriptional signatures of stem cell phenotypes in normal and clonal hematopoiesis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 2456.
Isolation and characterization of abaecin, a major antibacterial response peptide in the honeybee (Apis mellifera) (1990)

Honeybee (Apis mellifera) are frequently exposed to and likely to be infected by plant-associated bacteria. We mimicked this process by injecting bees with live bacteria and isolated five induced antibacterial substances by comparative liquid chromatographic mapping of the hemolymph. Three of these antibiotics belong to a unique family of small (18 amino acids) peptides: the apidaecins [Casteels et al. (1989) EMBO J. 8, 2387-2391]. We have now characterized a fourth bee immune response peptide. The complete sequence was established by Edman degradation of the peptide and fragments thereof. It is 34 amino acids long and contains 10 proline residues. The amino-terminal half is related to the apidaecins; similar proline motifs are also present in the amino-terminal quarter of the much longer fly diptericins. The newly identified peptide's broad spectrum, lower specific activities against Gram-negative plant pathogens and its inability to inhibit bacterial growth at medium ionic strength are different from the apidaecins. Moreover, the highest observed specific activity was against an apidaecin-resistant Xanthomonas strain. In contrast to the immediate action of apidaecins, bactericidal activity is delayed. We propose the name 'abaecin' for this new antibacterial response peptide.
Lupus Erythematosus POSSIBLE MECHANISM FOR SUPPRESSOR-CELL DYSFUNCTION (1979)

A B S T R A C T Circulatinig antibodies that could be responsible for the suppressor thymus-derived (T)-cell dysfunction in active systemic lupus erythematosus (SLE) were investigated. Sera from 14 active and inactive SLE patients were compared with a pool of 22 normal sera. All sera were adsorbed with a pool of normal platelets to exclude antihistocompatibility leukocyte antigen antibodies; with AB erythrocytes to exclude isohemagglutinins; and with a pool of normal bone marrow-derived (B) lymphocytes, monocytes, and neutrophils to deplete anti-B-cell antibodies, Fc-receptor antibodies, and antibodies directed against neutrophils or monocytes. Sera from active SLE patients were capable of inhibiting the activation of normal, blood lymphocytes by concanavalin A to become suppressor cells. The latter were assayed by coculturing the concanavalin A-activated cells with autologous lymphocytes, which were then activated with either phytohemagglutinin for proliferative response or with pokeweed mitogen for B-cell immunoglobulin (Ig) synthesis and secretion. Specific incorporation ofcultures with phytohemagglutinin showed a value of 67 +13 (mean±+-SD) for suppressor cells treated with adsorbed, active SLE sera. This value was significantly different (P < 0.001) from that of cells treated with the iniactive SLE sera or with the pool of normal sera. Similar findings were seen with respect to the B-cell target paraimeters. Cytoplasmic Ig and IgG in superncates of cultures with pokeThis study was presented at the Annual Meeting of the Americain Academy of Allergy and Clinical Immunology, Phoenix, Ariz., 27 February 1978. It has also appeared in