gebhart/patrepeval huggingface dataset:
Detection of Occult Melanoma Cells in Paraffin-Embedded Histologically Negative Sentinel Lymph Nodes Using a Reverse Transcriptase Polymerase Chain Reaction Assay (2001)

Although sensitivity is lowered by the use of paraffin-embedded specimens, our data indicate that RT-PCR analysis of serial sections from archival SLNs may be helpful in improving detection of occult micrometastases, thus improving staging of patients with melanoma.
Ferroelectric phase transition temperatures of KTiOPO4 crystals grown from self-fluxes (1995)

The origin of diversity in the reported ferroelectric phase transition (Curie) temperatures Tc, of KTiOPO4 (KTP) crystals grown from self-fluxes has been studied. A series of crystals has been grown by the top-seeded solution method from fluxes of different K/P molar ratios and solute concentrations, covering most of the KTP crystallization field in the K2O–P2O5–TiO2 ternary system. Curie temperatures of as-grown and high-temperature annealed crystals have been measured using the standard dielectric technique and found to spread from 883 to 960 °C. We show that the actual Tc values depend on the solution chemical composition, and a functional representation of this dependence is given. Inherent gradients of the Tc in as-grown KTP crystals are discussed in terms of the nonuniformity of their physical properties.
The live biotherapeutic Blautia stercoris MRx0006 attenuates social deficits, repetitive behaviour, and anxiety-like behaviour in a mouse model relevant to autism (2022)

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterised by deficits in social behaviour, increased repetitive behaviour, anxiety and gastrointestinal symptoms. The aetiology of ASD is complex and involves an interplay of genetic and environmental factors. Emerging pre-clinical and clinical studies have documented a potential role for the gut microbiome in ASD, and consequently, the microbiota represents a potential target in the development of novel therapeutics for this neurodevelopmental disorder. In this study, we investigate the efficacy of the live biotherapeutic strain, Blautia stercoris MRx0006, in attenuating some of the behavioural deficits in the autism-relevant, genetic mouse model, BTBR T+ Itpr3tf/J (BTBR). We demonstrate that daily oral administration with MRx0006 attenuates social deficits while also decreasing repetitive and anxiety-like behaviour. MRx0006 administration increases the gene expression of oxytocin and its receptor in hypothalamic cells in vitro and increases the expression of hypothalamic arginine vasopressin and oxytocin mRNA in BTBR mice. Additionally at the microbiome level, we observed that MRx0006 administration decreases the abundance of Alistipes putredinis, and modulates the faecal microbial metabolite profile. This alteration in the metabolite profile possibly underlies the observed increase in expression of oxytocin, arginine vasopressin and its receptors, and the consequent improvements in behavioural outcomes. Taken together, these findings suggest that the live biotherapeutic MRx0006 may represent a viable and efficacious treatment option for the management of physiological and behavioural deficits associated with ASD.
Accuracy of Contrast-Enhanced Dual-Energy MDCT for the Assessment of Iodine Uptake in Renal Lesions (2014)

Contrast-enhanced dual-energy MDCT with iodine-related attenuation and iodine quantification allows accurate evaluation of iodine uptake in renal lesions on a single-phase nephrographic image.
Generation and analysis of blueberry transcriptome sequences from leaves, developing fruit, and flower buds from cold acclimation through deacclimation (2012)

These results indicate that this large collection of 454 ESTs will be a valuable resource for identifying genes that are potentially differentially expressed and play important roles in flower bud development, cold acclimation, chilling unit accumulation, and fruit development in blueberry and related species. In addition, the ESTs have already proved useful for the development of SSR and EST-PCR markers, and are currently being used for construction of genetic linkage maps in blueberry.
Thymidine kinase and deoxycytidine kinase activity in mononuclear cells from antiretroviral-naive HIV-infected patients (2005)

A marked range of inter-individual variability of TK and dCK activities in PBMC exists in HIV-infected individuals but not in healthy volunteers, indicating that the activity of enzymes with key roles in drug activation could vary greatly from one patient to another. Furthermore, TK expression is greater in HIV-infected individuals than in healthy volunteers. Better understanding of the viral or cellular factors that contribute to this variability, as well as their effect on responses to antiretroviral treatment, may aid optimization of the management of HIV-infected patients.
Non-uniform stress distribution in FRP-wrapped circular concrete columns under uniform axial deformation (2012)

The confinement of concrete columns using bonded FRP wraps has become a popular retrofit technique. Through extensive research in the last two decades, many stress-strain models have been developed for concrete in FRP-wrapped circular columns. All these models assume that the stress state is axisymmetric in an FRP-wrapped circular concrete column under concentric axial compression. This implies that the FRP wrap is assumed to be axisymmetric in geometry, but in reality such axisymmetry is not realised due to the existence of an overlapping zone. This paper presents a finite element investigation into the stress state in FRP-wrapped circular concrete columns considering the actual FRP wrap geometry used in laboratory tests and practice. The results show that common FRP wraps with an overlapping zone can lead to significant non-axisymmetric confinement to the concrete and hence a significantly non-uniform stress distribution in the concrete, even when the concrete is under uniform axial shortening.
Ten-year study comparing enzyme-linked immunosorbent assay with the immunofluorescent antibody test for detection of feline leukemia virus infection in cats. (1991)

Immunodetection tests for feline retroviruses are powerful tools used in modern veterinary practice. Veterinarians must fully understand the characteristics--strengths and weaknesses--of the FeLV tests so that the information gained from them can be used properly. Any FeLV ELISA or immunofluorescent antibody (IFA) test is a method for detection of FeLV infection (the virus) and is not a diagnostic test for leukemia or other feline disease. From previous studies, it was determined that the most accurate test for detection of persistent FeLV infection is the IFA test, which detects FeLV antigens in cytoplasm of leukocytes in the blood of infected cats. In the study reported here, 1,142,600 FeLV IFA tests were performed between June 1972 and December 1990. During this period 19.8% of the IFA test results were positive and 78% were negative. Evaluation was not possible for the remaining 2.2% of the tests because of lack of enough leukocytes in the smears to evaluate, or nonspecific staining reactions. In 1979, 7 years after introduction of the IFA test, in-hospital FeLV ELISA were introduced, which enabled veterinarians to test for FeLV in their hospitals. Ever since that time, continual discrepancies have been reported between results of FeLV ELISA and IFA tests, particularly between positive ELISA results and their IFA test confirmation. A 10-year comparison was made between practitioner-performed in-hospital FeLV ELISA (n = 20, 240 tests) results and FeLV IFA test performed by a commercial laboratory. All samples tested by ELISA were submitted (for confirmation of results) by veterinarians from the United States, Canada, Europe, Japan, and Australia.(ABSTRACT TRUNCATED AT 250 WORDS)
Modular Assembly of Macrocyclic Organo–Peptide Hybrids Using Synthetic and Genetically Encoded Precursors (2011)

Mix, click, cyclize: Conformationally constrained organo–peptide hybrids can be constructed by a tandem chemoselective reaction between a synthetic molecule and a recombinant protein. Diverse macrocyclic structures were obtained in cyclic, lariat, and protein-tethered configurations by varying the nature of the synthetic and biosynthetic precursors. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
IncentiveChain: Blockchain Crypto-Incentive for Effective Usage of Power and Water in Smart Farming (2022)

This paper discusses how agriculture has become one of the prime reasons for the wastage of energy and water during food production. In order to control the use of resources in farming, we introduce a novel concept called IncentiveChain. The application idea is to distribute crypto ether as a reward to the farmers because they play key roles in keeping a check on resource usage and can benefit through these schemes economically. We provide a state-of-the-art architecture and design, which includes participation from national agricultural departments and local regional utility companies to embed various technologies and data together to make the IncentiveChain application practical. We have successfully implemented IncentiveChain to show the transfer of ether from utility company accounts to farmer accounts and the currency being collected by the farmer in a more secure way using the blockchain, removing third-party vulnerabilities.
Enhanced expression of vascular endothelial growth factor in lungs of newborn infants with congenital diaphragmatic hernia and pulmonary hypertension (1999)

This is the first study of VEGF expression in newborn infants with CDH. Increased levels of VEGF, especially in the small, pressure regulating pulmonary arteries, point to a potential role in vascular remodelling. This may reflect an unsuccessful attempt by the developing fetus to increase the pulmonary vascular bed in the hypoplastic lungs to alleviate the associated pulmonary hypertension.
[Alternatives for castration of suckling piglets, determination of catecholamines and wound healing after castration of suckling piglets at different points of time]. (2006)

According to the applicable animal welfare legislation, the surgical castration of pigs is allowed up until the age of 4 weeks, without anaesthesia. According to the european guideline (2001/93/EG) it is only permitted in the first week after birth. The investigation should show, whether the castration of young piglets takes a milder course and to what extent stress reactions occur in different age groups. The healing process of castration wounds in piglets that were castrated at the age of four days progressed more rapidly and with less complications than those piglets that were castrated at 28 days of age. The catecholamine levels in younger piglets rose significantly after the operation, while these levels virtually stayed the same in piglets castrated at 28 days. As alternatives to castration without anaesthesia, several methods are in discussion: (1) Castration under general anaesthesia can only be practiced by a veterinary surgeon. The sole use of Azaperon and Ketamine has insufficient pain sedating effect. Isofluran anaesthesia is apparatively extravagant. (2) CO2-Anaesthesia in piglets leads to high strain. (3) Castration under local anaesthesia must be practiced by a veterinary surgeon. The application and the pain after the castration are not taken into consideration. (4) Jung boar fattening up until the slaughtering weight of 80 kg is not transformable, because of boar taste. (5) The breeding of slaughter pigs with little boar taint is not yet transformable. (6) Sperm sexing is not and will not, in the near future, be mature for practice. (7) Immunocastration is an active immunisation against GnRH. The immunological elimination of GnRH suppresses the development of sex hormones, such as testosterone, as well as the substance responsible for boar taint, Androstenone. To consider is the acceptance of the consumer. The preparation has the same effect in humans as it has in swine. "Self injections" have the same effect in humans as it has in swine. "Self injections" are therefore risky.
[A comparison of the two anticholinergic agents atropine and glycopyrrolate during antagonism of a muscle relaxation with pyridostigmine]. (1993)

Central, peripheral and cardiac side-effects of both anticholinergic drugs atropine and glycopyrrolate were compared during the antagonism of muscle relaxation with pyridostigmine. In a randomized, double-blind fashion 50 patients were given 10 micrograms/kg of atropine and 50 were given 5 micrograms/kg of glycopyrrolate with 125 micrograms/kg pyridostigmine intravenously. Continuous Holter ECG-monitoring over 3 hours was performed. The procedure was divided into the following phases: control (5 minutes before application of antagonists), phase I (application of antagonists and the following 5 minutes), phase II (subsequent 30 minutes), phase III (until 3 hours had passed). The first 32 minutes were subdivided into periods of 4 minutes. Analysed were: 1st: The number of patients with supraventricular, junctional and ventricular beats, 2nd: The mean heart rate per period, 3rd: The incidence of central-anticholinergic syndromes and the peripheral antimuscarinic side-effects. Supraventricular beats were found after atropine in 42 patients and after glycopyrrolate in 18 patients (p < 0.001). The differences mainly occurred during phase I (atropine 15 vs. glycopyrrolate 4 p < 0.05) and III (atropine 38 vs. glycopyrrolate 18, p < 0.01). Junctional beats were found after both drugs (atropine 7 vs. glycopyrrolate 10), above all during phase III. Ventricular beats were observed after atropine (21) and glycopyrrolate (18). Atropine as well as glycopyrrolate caused an increased heart rate within the first 4 minutes (atropine 47% vs. glycopyrrolate 27%, p < 0.01). During phase III after atropine, the heart rate decreased below the control value (p < 0.05). None of the patients showed central anticholinergic syndromes after either drug.(ABSTRACT TRUNCATED AT 250 WORDS)
Proposal for a Hub Controlled Cable Television System Using Optical Fiber (1979)

A practical hub oriented optical fiber TV distribution system is described. Pulse Width Modulation is utilized for ease in switching and a simple set-top coverter delivers pictures to a conventional TV set. A low cost connector concept is also discussed.
Robust Local Features and their Application in Self-Calibration and Object Recognition on Embedded Systems (2007)

In recent years many powerful computer vision algorithms have been invented, making automatic or semiautomatic solutions to many popular vision tasks, such as visual object recognition or camera calibration, possible. On the other hand embedded vision platforms and solutions such as smart cameras have successfully emerged, however, only offering limited computational and memory resources. The first contribution of this paper is the investigation of a set of robust local feature detectors and descriptors for application on embedded systems. We briefly describe the methods involved, i.e. the DoG (difference of Gaussian) and MSER (maximally stable extremal regions) detector as well as the PCA-SIFT descriptor, and discuss their suitability for smart systems and their qualification for given tasks. The second contribution of this work is the experimental evaluation of these methods on two challenging tasks, namely fully embedded object recognition on a moderate size database and on the task of robust camera calibration. Our approach is fortified by encouraging results we present at length.
CoSiNeT: A Lightweight Clock Synchronization Algorithm for Industrial IoT (2021)

Recent advances in the industrial internet of things (IIoT) and cyber-physical systems drive Industry 4.0 and lead to advanced applications. The adequate performance of time-critical automation applications depends on a clock synchronization scheme used by control systems. Network packet delay variations adversely impact the clock synchronization performance. The impact is significant in industrial sites, where software and hardware resources heavily contribute to delay variations and where harsh environmental conditions interfere with communication network dynamics. While existing time synchronization methods for field IIoT end-devices, e.g., Simple Network Time Protocol (SNTP), provide adequate synchronization in good operating conditions, their performance degrades significantly with deteriorating network conditions. To overcome this issue, we propose a scalable, software-based, lightweight clock synchronization method, called CoSiNeT, for IIoT end-devices that maintains precise synchronization performance in a wide range of operating conditions. We have conducted measurements in local network deployments such as home and a university campus in order to evaluate the proposed algorithm performance. The results show that CoSiNeT matches well with SNTP and state-of-the-art method in good network conditions in terms of accuracy and precision; however, it outperforms them in degrading network scenarios. In our measurements, in fair network conditions, CoSiNeT improves synchronization performance by 56% and 73% compared to SNTP and state-of-the-art method. In the case of poor network conditions, it improves performance by 76% and 74%, respectively.
Treatment of Gram-Negative Peritonitis with Aztreonam in Patients Undergoing Continuous Ambulatory Peritoneal Dialysis (1991)

In a multicenter open study, intraperitoneal aztreonam was used together with vancomycin, cloxacillin, or flucloxacillin for initial empiric treatment of peritonitis associated with continuous ambulatory peritoneal dialysis (CAPD). Monotherapy with aztreonam was continued in 34 episodes of gram-negative peritonitis in 28 patients. The microorganisms isolated included Escherichia coli, Acinetobacter species, Pseudomonas species, and Klebsiella species. In three episodes, two organisms were cultured. Microbiologic assessment revealed cure in 27 episodes, cure with relapse in two, cure with superinfection in one, and treatment failure in four (with resistance to aztreonam in three). As assessed by clinical criteria, 27 episodes were cured, five failed to respond, and two responded partially. No adverse reactions to aztreonam were observed. Comparison of these 34 episodes with 35 episodes in historical controls (treated mainly with aminoglycosides and/or trimethoprim-sulfamethoxazole) showed significantly higher rates of cure (84% vs. 51%) and of survival (97% vs. 86%) as well as lower rates of catheter removal (65% vs. 87%) with aztreonam. Thus aztreonam is a safe and efficient agent for the treatment of peritonitis caused by gram-negative organisms in patients undergoing CAPD.
Integral Sliding Mode Control for Starting Speed Sensorless Controlled Induction Motor in the Rotating Condition (2019)

Starting in the rotating condition is an important technology for induction motor (IM) speed sensorless control. The key of this technology is that the initial speed of the IM in the rotating condition should be estimated quickly and accurately. In this article, an integral sliding mode control method based on the nonlinear model of the rotor back electromotive force is designed to start a speed sensorless controlled IM in the rotating condition. The stability is guaranteed by Lyapunov stability analysis, and the robustness to rotor time constant and disturbance are analyzed. Meanwhile, in comparison with the proposed control method, the existing input-output feedback linearization (IOFL) control method is introduced and the stability and robustness are also analyzed. Compared with the existing IOFL control method, the proposed control method can estimate the initial speed in the rotating condition without overshoot and has better dynamic performance and robustness. In addition, the proposed control method can be applied not only to the restart operation but also to the normal operation. Only a single control strategy is required from the restart operation to the normal operation. The proposed method is verified by simulation and experiments using a 7.5 kW IM.
Interference alignment with improved stream selection in heterogeneous networks (2015)

In this article, interference that occurs in heterogeneous networks is studied and a new stream selection approach with an interference alignment solution is presented. In the proposed algorithm, stream selection starts with the streams that belongs to the pico cell users and continues to select the strongest streams that increase the total sum rate. The power of each stream with the precoding and the postcoding vectors are calculated by performing singular value decomposition (SVD). Virtual channels that belong to the selected stream are calculated by using precoding and postcoding vectors. After the selection procedure, the interferences between the selected stream and the remaining streams are mitigated by orthogonally projecting the channel matrices of the remaining streams to the virtual channels of the selected stream.
Hybrid system of nickel–cobalt hydroxide on carbonised natural cellulose materials for supercapacitors (2017)

Advanced carbon materials formed from abundant biomass are an exciting and promising class for energy devices due to the clear advantages of low cost, sustainability and good physical and electrochemical properties. However, these materials typically do not compete well with their metal functionalised counterparts. In this work, we demonstrate that xCo(OH)2–(1−x)Ni(OH)2 with various Ni:Co ratios can be deposited onto biomass-derived carbon to make a hybrid inorganic-carbon electrode with tuneable physical features and electrochemical performance. These features were tuned by adjusting the Ni:Co ratio within precursor solutions. The electrodes had shown a capacitance ranging from 780.7 to 2041 F g−1, which is very close to the theoretical value for Ni(OH)2 (2365 F g−1). A hypothesis is presented to help explain this performance for a modified, biomass-derived carbon electrode.
Zirconium-Containing Mesoporous Silica with High Alkaline Resistance. (2001)

Zirconium was introduced to MCM-41 and MCM-48 in order to improve the resistance to alkaline solution. In this research, zirconium-containing mesoporous silicas (Zr-MCM-41 and Zr-MCM-48) were synthesized from tetraethylorthosilicate (TEOS), zirconium(IV)propoxide (ZrPr), sodium hydroxide (NaOH), the quaternary ammonium surfactant (cetyltrimethylammoniumbromide: CTAB) and deionized water. The XRD, TEM and nitrogen adsorption measurements show that zirconium-containing products have high quality of ordered structure of MCM-41 and MCM-48. The pore volume and the specific surface area of Zr-MCM-41 and Zr-MCM-48 are similar to those of pure silica samples. These materials show high stability in the alkaline solutions.