gebhart/patrepeval huggingface dataset:
Advances in the study of fundus gland polyps in the elderly (2017)

Fundus gland polyp is the most common type of gastric polyp, which occurs in middle-aged and elderly people over the age of 50. The incidence of gastric polyp is increasing year by year. Proton pump inhibitors are the first-line drugs for the treatment of acid related diseases of the digestive system, the present study found that it can lead to the onset of fundic gland polyps. In addition, aging is risk factor of fundus gland polyps, which may be related to gastric aging. However, studies have shown that the elderly stomach still has a good secretion of acid function, suggesting that the elderly prone to fundus gland polyps may be associated with high incidence of gastroesophageal reflux, and the usage of proton pump inhibitors. Although Helicobacter pylori infection may cause gastritis, peptic ulcer, gastric lymphoma lymphoproliferative disease, studies show that it is a protective factor of fundic gland polyps, which may be related to gastric gland atrophy. In addition, recent studies have shown that fundus gland polyps occurrence is correlated with colorectal cancer, and patients with fundus gland polyps should undergo colonoscopy screening for colorectal cancer or adenomatous polyps. Treatment of the fundus gland polyps is considered to stop proton pump inhibitors. If accompanied by abnormal hyperplasia, endoscopic resection should be considered, and the prognosis is good.


Key words: 
Aged; Fundus gland polyps; Proton pump inhibitors; Helicobacter pylori; Colorectal neoplasms
Approach to the new oral anticoagulants in family practice: part 2: addressing frequently asked questions. (2014)

Management of "what if" scenarios for patients taking NOACs have been proposed, but additional study is needed to address these issues, especially periprocedural management and bleeding.
Discriminatory effects of protein kinase inhibitors and calcium ionophore on endothelial ICAM-1 induction (1992)

Intercellular adhesion molecule 1 (ICAM-1) is a proinflammatory adhesion glycoprotein induced by cytokines such as interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) as well as lipopolysaccharide (LPS). Little is known, however, concerning the intracellular regulatory mechanisms that modulate ICAM-1 expression in endothelial cells. We probed the involvement of protein kinase function and intracellular calcium ion upon ICAM-1 expression of human umbilical vein endothelial cells activated alternatively by TNF-alpha, IL-1 beta, LPS, or phorbol 12-myristate 13-acetate (PMA). Methodologies for the detection of ICAM-1 included both enzyme-linked immunosorbent assay and immunoprecipitation from biosynthetically labeled cells. The protein kinase inhibitor H-7 blocked induction of ICAM-1 by all of the activators; nonlinear regression analysis revealed 50% inhibitory concentration (IC50) values of 6-10 microM. Another kinase inhibitor, HA1004, did not block expression of the adhesion molecule at concentrations up to 50 microM. In contrast, the kinase inhibitor staurosporine dose dependently inhibited ICAM-1 expression triggered by PMA (IC50 67 +/- 4 nM) but, at similar concentrations, did not inhibit ICAM-1 expression induced by the other inflammatory stimuli. The divalent cation ionophore ionomycin (0.5 microM) interacted synergistically with PMA but not with cytokines or LPS in upregulating ICAM-1. We conclude from these data that although PMA-induced ICAM-1 expression may be triggered through activation of protein kinase C, ICAM-1 induction by IL-1 beta, TNF-alpha, or LPS may involve distinct regulatory pathway(s).
Stable albinism induced without mutagenesis: a model for ribosome‐free plastid inheritance (1998)

Maternally inherited chlorophyll deficiency, or albinism, is a standard marker in plant cytoplasmic genetics. Its stability is consistent with mutations in the plastid genome. Nuclear mutations inducing plastid ribosome deficiency (PRD) also lead to maternally inherited chlorophyll deficiency. Here we report that stable chlorophyll deficiency can be efficiently generated in cruciferous plants without mutagenesis by a short exposure to spectinomycin, an inhibitor of plastid protein synthesis. We show that the chlorophyll-deficient phenotype results from a deficiency in plastid ribosomes and plastid translation products. Loss of plastid ribosomes is irreversible. The data suggest that mutations are not essential for generating inheritable PRD. It allows the formulation of a more general model in which stable PRD can be induced by a variety of factors that prevent the formation of functional plastid ribosomes. A non-mutational mechanisms for generating inheritable chlorophyll deficiency has implications for the origin and inheritance of green-white variegation in nature.
Model‐predictive safety optimal actions to detect and handle process operation hazards (2020)

Abstract In 2016, we introduced the concept of model‐predictive safety (MPS; Ahooyi et al, AIChE J . 2016; 62:2024‐2042). MPS is a proposed innovation in functional safety systems to methodically account for process nonlinearities and variable interactions to enable predictive, prescriptive actions, while existing functional safety systems generally react when individual process variables exceed thresholds. MPS systematically utilizes a dynamic process model to detect imminent and potential future operation hazards in real time and to take optimal preventive and mitigative actions proactively. This work expands the concept of MPS and formulates two min–max optimization problems, offline solutions of which are the optimal proactive preventive and mitigating actions that MPS takes online, in response to predicted process operation hazards. A nested particle‐swarm optimization (PSO) algorithm is proposed to solve the min–max optimization problems. The application and performance of the min–max optimization formulations, the PSO algorithm, and MPS, applied to two chemical process examples, are shown through numerical simulations.
Effects of riociguat in severe experimental pulmonary hypertension (2011)

Introduction: The NO-sGC-cGMP signaling pathway is impaired in different cardiovascular diseases, including pulmonary hypertension (PH). Riociguat is the first of a new class of drugs, the sGC stimulators. Riociguat has a dual mode of action: it sensitizes sGC to the body's own NO and can also increase sGC activity in the absence of NO, causing vasorelaxation, anti-proliferation and anti-fibrotic effects. Aim: The aim of the study was to investigate the effects of riociguat as compared to the PDE5 inhibitor sildenafil on pulmonary vascular remodeling in severe experimental PH. Methods: Angioproliferative PH was induced in rats by combined exposure to the VEGFr antagonist SU5416 and hypoxia. 21 days thereafter, rats were randomized for treatment with riociguat (10 mg/kg), sildenafil (50 mg/kg) or vehicle for the next 14 days. Echocardiography and invasive hemodynamic measurements were performed. Pulmonary vascular remodeling was assessed by histomorphomety. Results: In rats with established PH, RVSP was significantly decreased by treatment with riociguat to 73±4 mmHg (p&lt;0.01) and sildenafil to 80±3 mmHg (p&lt;0.05) as compared to placebo (89±3 mmHg). No significant difference in systemic arterial pressure was detected between placebo and treated animals. Both compounds significantly decreased RV hypertrophy and improved RV function by normalization of TAPSE and Tei index, but effects of riociguat were more pronounced. Riociguat significantly reduced the proportion of occluded arteries, increased proportion of opened arteries and decreased neointima/media ratio. Conclusion: We demonstrated that riociguat effectively suppresses pulmonary vascular remodeling and significantly improves RV function in an experimental model of PH.
A Neural Network Parallel Adaptive Controller for Fighter Aircraft Pitch-Rate Tracking (2010)

A fighter aircraft pitch-rate command-tracking controller based on a neural network parallel controller is proposed. The scheme consists of an online radial basis function neural network (RBFNN) in parallel with a model reference adaptive controller (MRAC) and uses a growing dynamic RBFNN to augment MRAC. Updating the RBFNN width, the center and weight characteristics are performed such that the error reduction and improved tracking accuracy are accomplished. The RBFNN architecture adapts its centers and radii and tunes the relevant parameters, dynamically addressing the issues related to initial error and dimensional growth inherent in static neural network design. The total control signal is used to change the elevator deflection, keeping the other control surface deflections at random values, even when the aircraft operates at different maneuvers. Moreover, a suitable reference model structure is used for all aircraft operating modes, and the system is then fully tuned by the parallel controller. The strength of the proposed scheme is in its ability to effectively perform, even when plant mode swings and functional changes occur. Theoretical results are validated by conducting simulation studies on a nonlinear F16 fighter aircraft model operating at different modes created by a randomly changing parameter set.
Modeling Viral Kinetics and Treatment Outcome During Alisporivir Interferon-Free Treatment in Hepatitis C Virus Genotype 2 and 3 Patients (2013)

ALV plus RBV may represent an effective IFN-free treatment that is predicted to achieve high SVR rates in patients with HCV genotype 2 or 3 infection.
Investigating the Impact of Actual and Modeled Occupant Behavior Information Input to Building Performance Simulation (2021)

Occupant behaviors are one of the most dominant factors that influence building energy use. Understanding the influences from building occupants can promote the development of energy–efficient buildings. This paper quantifies the impact of different occupant behavior information on building energy model (BEM) from multiple perspectives. For this purpose, an occupant behavior model that uses agent–based modeling (ABM) approach is implemented via co-simulation with a BEM of an existing commercial building. Then, actual occupant behavior data in correspondence to ABM output, including operations on window, door, and blinds in selected thermal zones of the building are recorded using survey logs. A simulation experiment is conducted by creating three BEMs with constant, actual, and modeled occupant behavioral inputs. The analysis of the simulation results among these scenarios helps us gain an in–depth understanding of how occupant behaviors influence building performance. This study aims to facilitate robust building design and operation with human–in–the–loop system optimization.
Java 2 distributed object middleware performance analysis and optimization (2000)

This paper is focused on the performance analysis, comparison and optimization of distributed object middleware for Java 2: RMI (Remote Method Invocation), CORBA IDL (Interface Definition Language) and RMI-IIOP (Remote Method Invocation on Internet Inter-ORB Protocol). The paper presents the following contributions to the research on distributed object performance. First, a detailed performance analysis is provided with the comparison. These results help to understand how the models perform. Second, an overhead analysis has been done, which explains why there are differences in peRformance. Third, optimizations and improved performance for RMI-IIOP and CORBA IDL are presented. These show considerably better performance in all areas compared to the original versions.
Transformed Representations for Convolutional Neural Networks in Diabetic Retinopathy Screening (2014)

Convolutional neural networks (CNNs) are flexible, biologically-inspired variants of multi-layer percep-trons that have proven themselves to be exceptionally suited to discriminative vision tasks. However, rela-tively little is known on whether they can be made both more efficient and more accurate, by introducing suitable transformations that exploit general knowledge of the target classes. We demonstrate this functionality through pre-segmentation of input images with a fast and robust but loose segmentation step, to obtain a set of candidate objects. These objects then undergo a spa-tial transformation into a reduced space, retaining but a compact high-level representation of their appearance. Additional attributes may be abstracted as raw features that are incorporated after the convolutional phase of the network. Finally, we compare its performance against existing approaches on the challenging problem of de-tecting lesions in retinal images.
The Configuration of Random Polypeptide Chains. I. Experimental Results (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Configuration of Random Polypeptide Chains. I. Experimental ResultsDavid A. Brant and Paul J. FloryCite this: J. Am. Chem. Soc. 1965, 87, 13, 2788–2791Publication Date (Print):July 1, 1965Publication History Published online1 May 2002Published inissue 1 July 1965https://pubs.acs.org/doi/10.1021/ja01091a002https://doi.org/10.1021/ja01091a002research-articleACS PublicationsRequest reuse permissionsArticle Views443Altmetric-Citations151LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Improved Therapeutic Efficacy of Doxorubicin through Conjugation with a Novel Peptide Drug Delivery Technology (Vectocell) (2006)

Improvement in the therapeutic index of doxorubicin, a cytotoxic molecule, has been sought through its chemical conjugation to short (15-23 amino acid) peptide sequences called Vectocell peptides. Vectocell peptides are highly charged drug delivery peptides and display a number of characteristics that make them attractive candidates to minimize many of the limitations observed for a broad range of cytotoxic molecules. The studies reported here characterized the in vitro and in vivo efficacy of a range of Vectocell peptides conjugated to doxorubicin through different linkers. These studies show that the in vivo therapeutic index of doxorubicin can be improved by conjugation with a specific Vectocell peptide (DPV1047) through an ester linker to C14 of doxorubicin, in both colon and breast tumor models. This conjugate was also shown to have significant in vivo antitumoral activity in a model resistant to doxorubicin, suggesting that this conjugate is able to circumvent the multidrug resistance (MDR) phenotype. These experiments therefore provide support for the use of the Vectocell technology with other cytotoxic agents.
Photophysics of Polymers: Preface (1987)

SIGNIFICANT QUESTIONS ARE ARISING as the field of polymer science continues to develop.Many of these questions can be addressed only at the most fundamental levels.Polymer photophysics has evolved over the past two decades, providing the polymer scientific community with a viable tool for probing polymer structure on a molecular scale.Herein lies its true value.By investigating photophysical phenomena of polymer systems, we can develop an accurate picture of how polymers exist in solution and in solid phases.
The Game Producer's Handbook (2005)

Coverage includes- DAN IRISH is formerly Executive Producer at Relic Entertainment, where he was responsible for Homeworld2, the sequel to the 1999 Game of the Year, Homeworld. Prior to working at Relic Entertainment, he was the producer responsible for the Myst/Riven franchise at Mattel Interactive and UbiSoft Entertainment, where he produced or started development of several Myst-related products, including realMyst, Myst III: Exile, and Myst IV: Revelation. Prior to working at Mattel Interactive, he held positions at Rocket Science Games, Spectrum HoloByte, and SegaSoft. He has also consulted on a number of interactive entertainment opportunities for such clients as DreamWorks Interactive, Evans & Sutherland's Digital Theater Division, Game Audio Network Guild, Auran Games, and Hanbitsoft. Explains the differences and similarities of producing for various media forms. Covers successful techniques for working with corporate executives and decision makers. Starts at the beginning, explaining what a producer does and the types of producer roles that exist. Explains how a producer effectively conveys a winning video game vision.
A Giant Ovarian Tumor Causing Anasarca and Dyspnea Successfully Managed after Preoperative Drainage (2015)

Serious complications are likely to accompany the treatment of giant ovarian tumors, and resection with or without preoperative drainage has been previously reported. Here, we report the case of a 27-year-old Japanese woman with a significant weight gain of 50 kg, who was referred to the Kumamoto University Hospital because of gait impairment and dyspnea. Imaging tests revealed an ovarian tumor, 37 cm in diameter, with two solid components. The patient's condition improved after the removal of 31.5 l tumor fluid by using a suprapubic urinary catheter for 3 days. The tumor was subsequently resected without complications, and was diagnosed as a left mucinous ovarian tumor with malignant components, weighing 37 kg (81.5 lb). The patient was discharged after her anasarca improved, and her body weight decreased from 100 to 50 kg with accompanying considerable urination within two weeks. She was in good condition with no evidence of recurrence at 15 months after surgery. Tumor resection after preoperative drainage was effective in the management of a patient with dyspnea induced by a giant ovarian tumor. We suggest the use of a suprapubic urinary catheter for preoperative drainage because of its ease of use in preventing fluid leakage from the possibly malignant tumor.
The United States and South America; The Northern Republics. By Arthur P. Whitaker. (Cambridge, Mass.: Harvard University Press. 1948. Pp. xix, 280. $3.50.) (1949)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Local Structure and Dynamics in Solvent-Swollen Polymers (1996)

We report atomistically detailed molecular dynamics simulations of benzene−polystyrene systems (0−84.2 wt % polystyrene). We have calculated solvent diffusion coefficients and have found that their composition dependence not only shows good agreement with experiment but also follows quite well the predictions by lattice models. We also show that, for the polystyrene−benzene system studied here, it is not possible to separate solvent molecules into slow ones, tightly bound to the polymer, and fast ones, not bound to the polymer. This would suggest that, in a gel, the polymer chains alone act as obstacles to solvent diffusion and not polymer decorated by a shell of solvent molecules. We have found the reorientation of benzene molecules in the gel to be nonexponential and anisotropic, the reorientation of the ring normal being slower than the in-plane reorientation. This anisotropy increases dramatically with polystyrene concentration. At the highest polymer concentration, the time scales for the two motions are separated by 3 orders of magnitude. The changes of polymer solvation and polymer dynamics with concentration are discussed. For all polymer concentrations above 50 wt %, the polymer turns out to be essentially rigid on a nanosecond time scale with only local fluctuations possible.
A Novel Fast and Robust Binary Affine Invariant Descriptor for Image Matching (2014)

As the current binary descriptors have disadvantages of high computational complexity, no affine invariance, and the high false matching rate with viewpoint changes, a new binary affine invariant descriptor, called BAND, is proposed. Different from other descriptors, BAND has an irregular pattern, which is based on local affine invariant region surrounding a feature point, and it has five orientations, which are obtained by LBP effectively. Ultimately, a 256 bits binary string is computed by simple random sampling pattern. Experimental results demonstrate that BAND has a good matching result in the conditions of rotating, image zooming, noising, lighting, and small‐scale perspective transformation. It has better matching performance compared with current mainstream descriptors, while it costs less time.
Ausbildung (2004)

Mit dem stetigen Strukturwandel in der Wirtschaft verändern sich nicht allein die Profile von Wirtschaftsbereichen und Unternehmen, sondern auch ganz wesentlich die Anforderungen an die Arbeitskräfte. Doch nicht nur die Belegschaften müssen sich anpassen, auch diejenigen, die vor dem Eintritt ins Berufsleben stehen, müssen anders auf ihre Aufgaben in den Betrieben vorbereitet werden als vor 20 Jahren. Die Fragen nach Ausbildungsformen und -inhalten müssen ständig neu gestellt und beantwortet werden. Zum einem ist das eine gesellschaftliche Aufgabe, zum anderen aber auch eine ureigene betriebswirtschaftliche, der sich jedes Unternehmen immer wieder erneut stellen muss.
The plant cannabinoid Δ9‐tetrahydrocannabivarin can decrease signs of inflammation and inflammatory pain in mice (2010)

THCV can activate CB(2) receptors in vitro and decrease signs of inflammation and inflammatory pain in mice partly via CB(1) and/or CB(2) receptor activation.
Orthogonal cylindrical diffractive lens for parallel readout optical disk system (1991)

A single hybrid refractive/diffractive lens element is designed to replace the multiple refractive cylindrical lenses present in the parallel readout optical disk system. The new system has less elements, simplified alignment, and significantly reduced aberrations. Experimental results are presented.
Plastic scintillator with effective pulse shape discrimination for neutron and gamma detection (2023)

In one embodiment, a scintillator material includes a polymer matrix; and a primary dye in the polymer matrix, the primary dye being a fluorescent dye, the primary dye being present in an amount of 5 wt % or more; wherein the scintillator material exhibits an optical response signature for neutrons that is different than an optical response signature for gamma rays. In another embodiment, a scintillator material includes a polymer matrix comprising at least one of: polyvinyl xylene (PVX); polyvinyl diphenyl; and polyvinyl tetrahydronaphthalene; and a primary dye in the polymer matrix, the primary dye being a fluorescent dye, the primary dye being present in an amount greater than 10 wt %. A total loading of dye in the scintillator material is sufficient to cause the scintillator material to exhibit a pulse-shape discrimination (PSD) figure of merit (FOM) of about at least 2.0.