gebhart/patrepeval huggingface dataset:
Structural Role of Plasma Membrane Sterols in Osmotic Stress Tolerance of Yeast Saccharomyces cerevisiae (2022)

Yeast <i>S. cerevisiae</i> has been shown to suppress a sterol biosynthesis as a response to hyperosmotic stress. In the case of sodium stress, the failure to suppress biosynthesis leads to an increase in cytosolic sodium. The major yeast sterol, ergosterol, is known to regulate functioning of plasma membrane proteins. Therefore, it has been suggested that the suppression of its biosynthesis is needed to adjust the activity of the plasma membrane sodium pumps and channels. However, as the sterol concentration is in the range of thirty to forty percent of total plasma membrane lipids, it is believed that its primary biological role is not regulatory but structural. Here we studied how lowering the sterol content affects the response of a lipid bilayer to an osmotic stress. In accordance with previous observations, we found that a decrease of the sterol fraction increases a water permeability of the liposomal membranes. Yet, we also found that sterol-free giant unilamellar vesicles reduced their volume during transient application of the hyperosmotic stress to a greater extent than the sterol-rich ones. Furthermore, our data suggest that lowering the sterol content in yeast cells allows the shrinkage to prevent the osmotic pressure-induced plasma membrane rupture. We also found that mutant yeast cells with the elevated level of sterol accumulated propidium iodide when exposed to mild hyperosmotic conditions followed by hypoosmotic stress. It is likely that the decrease in a plasma membrane sterol content stimulates a drop in cell volume under hyperosmotic stress, which is beneficial in the case of a subsequent hypo-osmotic one.
Influence of n-value and rise rate on the Magnetic Field Penetration in HTS Bulks (2015)

Poster
Cloning, expression, and alternative splicing of the receptor for anti-Müllerian hormone. (1994)

Anti-Müllerian hormone, also called Müllerian-inhibiting substance or factor, is a glycoprotein dimer belonging to the transforming growth factor-beta superfamily and synthesized by immature Sertoli cells and postnatal granulosa cells. Anti-Müllerian hormone plays a key role in sex differentiation by inducing the regression of Müllerian ducts in the male fetus. It is also responsible for the stunting and masculinization of fetal ovaries in bovine freemartin fetuses and may be involved in the control of follicular maturation in the postnatal ovary. Using a degenerate probe for a consensus region of the transforming growth factor-beta receptor superfamily to screen a complementary DNA library from rabbit fetal ovaries, we cloned a complementary DNA coding for a transmembrane serine/threonine kinase, which is expressed around the fetal Müllerian duct, in fetal and adult granulosa cells, and in immature Sertoli cells. Two transcripts, generated by alternative splicing of an exon coding for an N-terminal 61-amino acid domain, are strongly expressed in anti-Müllerian hormone target organs and Sertoli cells. The longer, 569-amino acid, isoform binds anti-Müllerian hormone when transiently expressed in COS cells and is believed to encode its functional receptor.
Figure S7 from Drugs That Modify Cholesterol Metabolism Alter the p38/JNK-Mediated Targeted and Nontargeted Response to Alpha and Auger Radioimmunotherapy (2023)

&lt;p&gt;SUPPLEMENTARY FIG. S7. Oxidative stress proteins activated in SK-OV-3MISRII and HCT116 cells after RIT.&lt;/p&gt;
Improved adherence to practice guidelines yields better outcome in high‐risk patients with acute coronary syndrome without ST elevation: findings from nationwide FINACS studies (2004)

In patients with non-ST elevation ACS-targeted educational interventions appeared to be associated with improved adherence to practical guidelines, which yielded a better outcome in high-risk ACS patients.
Efficacy of Oral Dipyridamole Cinemagnetic Resonance Imaging in Detecting Coronary Artery Disease - Initial Experience (1993)

Exercise or dipyridamole (DP) thallium-201 perfusion imaging is a widely accepted stress technique for the early detection of coronary artery disease. An alternative to perfusion imaging is the assessment of regional left ventricular function, which is felt to reflect the earliest signs of subendocardial and transmurai ischemia. We examined 13 patients with angiographically documented coronary artery disease (≥70% diameter stenosis) using cine-magnetic resonance imaging (C-MRI) before and after DP administration. Angiographic findings of the 3 major coronary arteries were compared with segmental wall motion and systolic wall thickening of the related left ventricular myocardial segments. The 39 left ventricular segments evaluated in these 13 patients demonstrated a 95% sensitivity (p < 0.01) and a 100% specificity (p > 0.05) when post-DP C-MRI results were assessed. In 4 patients, it was not possible to assess systolic wall thickening because of motion artifacts, but wall motion analysis with the cine-loop display was still possible. There was a trend toward superiority utilizing the qualitative cine-method rather than that of quantitative systolic wall tickening. DP C-MRI appears to be a promising method for the evaluation of left ventricular cardiac function.
Sex differences in the location of a spina bifida lesion. (1993)

Aphasia, deafness, or mental retardation Wilson et al' reported a new type of X linked mental retardation with 'striking aphasia' and other anomalies. I cannot find 'aphasia' indexed in three major databases.24 In con- trast, mental retardation occurs in 666 syn- dromes and deafness in 292.4 A priori, there- fore, the probability of language retardation being the result of aphasia rather than these two commoner conditions is remote. In order to establish a precedent for the use of 'apha- sia' as a titular keyword, or when postulating a speech gene, it is all the more important to ensure that there is not the slightest hint of mental retardation or deafness. This was certainly not so in the cases reported.
False positive reactions in confirmatory tests for syphilis in presence of antiphospholipid antibodies: misdiagnosis with prognostic and social consequences (2006)

False-positive reactions in the Venereal Disease Research Laboratory test are well known, whereas a positive fluorescent treponemal antibody absorption assay is rarely thought to be a false positive. The non-recognition of serological false-positive tests for syphilis may have negative prognostic and social implications.
The Association between Low Levels of Low Density Lipoprotein Cholesterol and Intracerebral Hemorrhage: Cause for Concern? (2022)

Excessive levels of low-density lipoprotein cholesterol (LDL-C) in the blood are a known risk factor for atherosclerosis, and a common target of treatment for primary and secondary prevention of cerebrocardiovascular disease. As lipid lowering agents including statins, ezetimibe and anti-proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors have shown good therapeutic results, the guidelines are constantly lowering the "optimal" LDL-C goals. However, old and new data point towards an association between low LDL-C and total cholesterol and intracerebral hemorrhage (ICH). In this review we aimed to shed light on this troubling association and identify the potential risk factors of such a potential adverse reaction. With respect to the data presented, we concluded that in patients with high risk of ICH, a cautious approach and individualized therapy strategy are advised when considering aggressive LDL reduction.
The Various Approximations of the Bimetallic Thermostatic Strip (1991)

A thin strip, formed by bonding two dissimilar materials, constitutes a simple thermostatic element. If edge effects are neglected, then the strip is reduced to a uniform beam, or plate, with two degrees-of-freedom. The flexure occurs only because of the bond and interfacial shear which is also accompanied by transverse normal stress. These latter stresses are very localized at the end and edges. Here, the elementary approximations, and refinements via finite elements, are presented and compared. Deflections are given with reasonable accuracy by the simple approximations, but the severe interfacial stresses are revealed only by the refinements.
ATF data system (1988)

The data system for the advanced toroidal facility (ATF) is a logical extension of the system used for the Impurity Studies Experiment ISX-B. Based on the ISX-B concepts and hardware, it extends them to provide support for long-pulse or steady-state operation of ATF. The system is now network based rather than shared memory based and can dynamically add or remove processors. The hardware consists of a pair of VAX 8700 CPUs and an assortment of MicroVAX front ends. This hardware acquires all data, generates all control waveforms, and provides trending and logging services for the safety interlock and control systems. These systems are based on programmable logic controllers (PLCs) which are independent of the data system. The software consists of three major components: a master scheduling and monitoring system (SAMS) that provides synchronizing services and allocates files and memory; a signal-based data and file management package (DMG) that provides data access services; and the ORNL CAMAC driver package. All diagnostics are supported by data acquisition and analysis software (either generic or specialized) that is based on and shared by these services.
OPTICAL-FAINT, FAR-INFRARED-BRIGHT HERSCHEL SOURCES IN THE CANDELS FIELDS: ULTRA-LUMINOUS INFRARED GALAXIES AT z > 1 AND THE EFFECT OF SOURCE BLENDING (2014)

The Herschel very wide-field surveys have charted hundreds of square degrees in multiple far-IR&#13;\n(FIR) bands. While the Sloan Digital Sky Survey (SDSS) is currently the best resource for optical&#13;\ncounterpart identifications over such wide areas, it does not detect a large number of Herschel FIR&#13;\nsources and leaves their nature undetermined. As a test case, we studied seven ''SDSS-invisible'', very&#13;\nbright 250 m sources (S250 &gt; 55 mJy) in the Cosmic Assembly Near-infrared Deep Extragalactic&#13;\nLegacy Survey (CANDELS) fields where we have a rich multi-wavelength data set. We took a new&#13;\napproach to decompose the FIR sources, using the near-IR or the optical images directly for position&#13;\npriors. This is an improvement over the previous decomposition efforts where the priors are from&#13;\nmid-IR data that still suffer from the source blending problem in the first place. We found that in&#13;\nmost cases the single Herschel sources are made of multiple components that are not necessarily at the&#13;\nsame redshifts. Our decomposition succeeded in identifying and extracting their major contributors.&#13;\nWe show that these are all ULIRGs at z 1 - 2 whose high LIR is mainly due to dust-obscured&#13;\nstar formation. Most of them would not be selected as sub-mm galaxies. They all have complicated&#13;\nmorphologies indicative of merger or violent instability, and their stellar populations are heterogeneous&#13;\nin terms of stellar masses, ages and formation histories. Their current ULIRG phases are of various&#13;\ndegrees of importance in their stellar mass assembly. Our practice provides a promising starting point&#13;\nto develop an automatic routine to reliably study bright Herschel sources.
Ethylene: Indicator but Not Inducer of Phytoalexin Synthesis in Soybean (1980)

Cell wall preparations (elicitors) from Phytophthora megasperma var. sojae increase C(2)H(4) formation, phenylalanine ammonia lyase activity, and glyceollin accumulation in soybean cotyledons within about 1.5, 3, and 6 hours after treatment, respectively. The immediate precursor of C(2)H(4), 1-aminocyclopropane-1-carboxylic acid, stimulates C(2)H(4) formation like the elicitor within 1.5 hours after administration, whereas phenylalanine ammonia lyase activity and glyceollin concentration remain unchanged. Aminoethoxyvinylglycine, a specific inhibitor of C(2)H(4) formation in higher plants, inhibits elicitor-induced C(2)H(4) formation by about 95% but has no effects on phenylalanine ammonia lyase or glyceollin accumulation. It was concluded that C(2)H(4) is a signal accompanying the specific recognition process which finally leads to the induction of phytoalexin formation, but it is not functioning as a link or messenger in the induction sequence of glyceollin accumulation.
Sprekend Nederland, a multi-purpose collection of Dutch speech (2021)

Abstract This contribution sketches the aims, participant recruitment and methodology of the Sprekend Nederland project, the amount and types of data, the research possibilities they offer and suggestions for similar future projects.
Inhibition of Aggregation of [Pd]-Bacteriochlorophyllides in Mesoporous Silica (2009)

Aggregation is a major factor affecting the photophysical properties of chlorophylls. For two [Pd]-bacteriochlorophyll derivatives that are currently under clinical testing as sensitizers for photodynamic therapy, aggregation control in aqueous solution has been studied with folded-sheet mesoporous silica (FSM) of different pore sizes (20, 45, 83 A) and with detergent (Triton X-100). With both the moderately polar WST09 and the highly polar WST11, no pigment oligomers were formed in FSM, and the monomer-dimer equilibrium was shifted toward the monomer with decreasing pore diameter.
A Cost-Aperture Study of a Family of Lenses (1966)

A series of five lenses ranging in aperture from f/1.0 to f/1.6 were designed with the aid of a large computer. A search was made for the least complex lens that would yield a given level of optical performance in an effort to optimize manufacturing costs with relation to lens speed for a family of lenses. Such a relationship was established.
IADSS: Intelligent Agent-Assisted Decision Support System for Diffusion-Based Molecular Nano Communication Networks (2019)

Although the cooperative transmission techniques have been developed for wireless sensor networks in recent years to improve the network transmission rate, delay and the bit error rate (BER) performance, the unique characteristics of the molecular communication (MC), such as implementing in nano-to-micro scale, the dynamic environment and the various network topology, make it extremely necessary to reconsider the implementation and analysis of the cooperative relay transmission. In this paper, we analyze and investigate the molecular communication network consisting of single transmitter and receiver nanomachines with the same type of carrier molecule. This communication takes place over an intelligent agent that aggregates the sensed data and simplify the complexity of the relaying algorithms to assist our communication channel, in which intermediate agent do not attempt to decode the information. This paper will describe a novel architecture to support the cooperative decision process by utilizing an intelligent agent in combination with pulse energy ratio and the sense-and-release technique. Furthermore, the inter-symbol interference (ISI) problem and reception noise are considered. The results illustrate that IADSS scheme is the powerful technique in improving the BER performance up to 10dB SNR gain compared to the State-of-the-Art relaying schemes. As a result, this scheme can be substantially reduced the complexity of the receiver's threshold-based detection strategy. Finally, experimental results show that the MC throughput of the entire network is greatly increased by exploiting the benefit of the cooperative intelligent agent with the sense-and-release technique.
Isolation of Gardnerella vaginalis from women attending gynaecological clinics and general practice surgeries. (1984)

deficiency. The refractoriness of thrombo- tic complications in this disorder to conven- tional heparin therapy4 is well illustrated. If the diagnosis had been made earlier and appropriate treatment, such as oral anti- coagulation or possibly infusion of anti- thrombin III concentrate, had been started, the unusual occurrence of a thrombotic death in a patient with acute myeloid leukaemia might have been avoided.
Variable-Speed Power-Turbine Research at Glenn Research Center (2012)

The main rotors of the NASA Large Civil Tilt-Rotor (LCTR) notional vehicle operate over a wide speed-range, from 100 percent at takeoff to 54 percent at cruise. The variable-speed power turbine (VSPT) offers one approach by which to effect this speed variation. VSPT aerodynamics challenges include high work factors at cruise, wide (40 to 60 ) incidence-angle variations in blade and vane rows over the speed range, and operation at low Reynolds numbers. Rotordynamics challenges include potential responsiveness to shaft modes within the 50 percent VSPT speed-range. A research effort underway at NASA Glenn Research Center, intended to address these key aerodynamic and rotordynamic challenges, is described. Conceptual design and 3-D multistage RANS and URANS analyses, conducted internally and under contract, provide expected VSPT sizing, stage-count, performance and operability information, and maps for system studies. Initial steps toward experimental testing of incidence-tolerant blading in a transonic linear cascade are described, and progress toward development/improvement of a simulation capability for multistage turbines with low Reynolds number transitional flow is summarized. Preliminary rotordynamics analyses indicate that viable concept engines with 50 percent VSPT shaft-speed range. Assessments of potential paths toward VSPT component-level testing are summarized.
Negative-curvature fullerene analog ofC60 (1992)

An analog of the ${\mathrm{C}}_{60}$ buckyball structure is investigated, in which seven-fold rings play the same role as the five-fold rings of ${\mathrm{C}}_{60}$. This periodic ${\mathrm{C}}_{168}$ structure is topologically ideal in the same sense as ${\mathrm{C}}_{60}$: Every atom is in a topologically equivalent local environment, participating in one seven-fold and two six-fold rings. The excess energy per atom to create this structure from an ideal graphitic sheet is predicted to be substantially less than for ${\mathrm{C}}_{60}$. If this material could be synthesized, we predict that it would have elastic constants comparable to those of Si, but with a density nearly half that of graphite.
The Black Horizon: Alterity and Ontology in the Anthropocene (2022)

This paper makes the case for an approach to International Relations in the Anthropocene, which draws upon resources from critical Black studies. This distinctive perspective is set out in comparison to two, more familiar, sets of critical Anthropocene thought, that have been influential in contemporary discussions of global politics. We heuristically frame these as the “Planetary” - a focus on ontology and vibrant and unruly materiality – and the “Pluriversal” - which places race and coloniality at the centre of our understanding of power and knowledge. We suggest that Planetary approaches underestimate the centrality of race and coloniality to questions of ontology and that Pluriversal approaches are often undermined by a failure to take ontology more seriously. These literatures are opposed to a third perspective, which we call the “Black Horizon”, which troubles our approach to alterity and works with a non- or para-ontological understanding of being.
Platelet Lipidomic Profiling: Novel Insight into Cytosolic Phospholipase A2α Activity and Its Role in Human Platelet Activation (2015)

With a newer, more selective and efficacious cytosolic phospholipase A2α (cPLA2α) inhibitor available, we revisited the role of cPLA2α activity in platelet activation and discovered that a component of platelet signaling, even larger than previously appreciated, relies on this enzyme. In a whole blood shear-based flow chamber assay, giripladib, a cPLA2α inhibitor, reduced platelet adhesion and accumulation on collagen. Moreover, giripladib differentially affected P-selectin expression and GPIIbIIIa activation depending on the agonist employed. While protease-activated receptor 1 (PAR1)-mediated platelet activation was unaffected by giripladib, the levels of PAR4- and GPVI-mediated platelet activation were significantly reduced. Meanwhile, the thromboxane A2 receptor antagonist SQ29548 had no effect on PAR-, GPVI-, or puriniergic receptor-mediated platelet activation, suggesting that another eicosanoid produced downstream of arachidonic acid liberation by cPLA2α was responsible for this large component of PAR4- and GPVI-mediated platelet activation. In parallel, we profiled PAR-mediated changes in glycerophospholipid (GPL) mass with and without giripladib to better understand cPLA2α-mediated lipid metabolism. Phosphatidylcholine and phosphatidylethanolamine (PE) demonstrated the largest consumption of mass during thrombin stimulation. Additionally, we confirm phosphatidylinositol as a major substrate of cPLA2α. A comparison of PAR1- and PAR4-induced metabolism revealed the consumption of more putative arachidonyl-PE species downstream of PAR1 activation. Instead of enhanced cPLA2α activity and therefore more arachidonic acid liberation downstream of PAR4, these results indicate the major role that cPLA2α activity plays in platelet function and suggest that a novel eicosanoid is produced in response to platelet activation that represents a large component of PAR4- and GPVI-mediated responses.
Differentiation of CD34~+ cells in human umbilical blood to eosinophils under the condition of cell culture in vitro (2006)

AIM: To investigate differentiation of CD34~+ cells in human umbilical blood into eosinophils under the condition of cell culture in vitro.METHODS: CD34~+ cells were separated and purified from human umbilical blood.The cells were divided into negative group,IL-5 group and allergic rhinitis serum group.The differentiation ability of the cells was measured by flow cytometry,HE staining and electron microscope at the first day,second day, 7th day,14th day and 28th day culture.RESULTS: The proportion of CD34~+ cells in IL-5 group and allergic rhinitis serum group were decreased at the second day.The proportion in allergic rhinitis serum group was lower than that in IL-5 group significantly.The typical structure of eosinophils was observed at the second day.CONCLUSION: The allergic patient serum and IL-5 induce differentiation of CD34~+ cells in human umbilical blood to eosinophils.
Coupling gratings as waveguide functional elements (1996)

Waveguide grating couplers allow the essential function of waveguide access to be integrated together with optical processing functions on a monolithic planar substrate. Grating coupling technology is topologically and, to a large extent, technologically compatible with the planar processes which define the optical processing waveguide circuit. Poor coupling efficiency, highly dispersive character, absence of user-friendly modelling tools and fabrication difficulties have long prevented this technology from being implemented into practical sensors and microsystems. This paper makes a review of the points where decisive technological progress has been made, illustrates some useful features of waveguide coupling gratings and underlines some of the difficulties which the designer may encounter.
Epidemiological Study of Hereditary Hemolytic Anemia in the Korean Pediatric Population during 1997–2016: a Nationwide Retrospective Cohort Study (2020)

In Korea, thalassemia traits have increased over the past 10 years, reflecting both increased awareness of this disease and increased international marriages. The enhanced recognition of RBC enzymopathies is due to advances in diagnostic technique; however, 6.5% of HHA patients still do not have a clear diagnosis. It is necessary to improve accessibility of diagnosing HHA.