gebhart/patrepeval huggingface dataset:
Determine the relationship between Ki 67 and Oncotype DX. (2016)

e12017 Background: Oncotype DX provides prognostic and predictive information for recurrence in early stage breast cancer patients. Recently an association of Ki67 with prognosis and response have been reported. However, evidence supporting the clinical utility of Ki67 is not sufficient to recommend routine use of this marker for prognosis and prediction of responsiveness to chemotherapy in patients with newly diagnosed early stage breast cancer. We examined the relationship of IHC-measured Ki 67 to Oncotype DX recurrence score. Methods: This retrospective study included 339 consecutive cases of hormone receptor-positive, HER2 negative (T1-2 N0 M0) breast cancer. Patients were divided into low risk (Ki67 < 10%), intermediate risk (10 ≥ Ki67 < 25) and high-risk group (Ki67 ≥ 25). Results: There is high concordance rate between Oncotype DX and Ki67: 88% of the patients in the high Oncotype DX RS group had a high Ki67 score while only 4 patients (1%) of patients with Ki67 < 25 (low and intermediate risks) had a high Oncotype DX RS. There was a modest but significant correlation between Oncotype DX RS and Ki 67 (r = 0.488, P value < 0.001). This correlation remains significant even after controlling for the effect of Nottingham grade and PR (r = 0.381, P value < 0.001). In a multiple regression analysis with Ki67, the size of tumour and Nottingham grade, only Ki67 can explain 52% of variations of Oncotype DX RS (standardized β = 0.487; P value < 0.001). Lower expression of PR is associated with higher Oncotype DX RS (r = 0.410). Conclusions: There is a moderate correlation between Ki67 and Oncotype DX RS. Long-term follow-up of these cases will determine if Ki67 can be used as a marker of distant relapse.
An electromechanical Ising Hamiltonian (2016)

Solving intractable mathematical problems in simulators composed of atoms, ions, photons, or electrons has recently emerged as a subject of intense interest. We extend this concept to phonons that are localized in spectrally pure resonances in an electromechanical system that enables their interactions to be exquisitely fashioned via electrical means. We harness this platform to emulate the Ising Hamiltonian whose spin 1/2 particles are replicated by the phase bistable vibrations from the parametric resonances of multiple modes. The coupling between the mechanical spins is created by generating two-mode squeezed states, which impart correlations between modes that can imitate a random, ferromagnetic state or an antiferromagnetic state on demand. These results suggest that an electromechanical simulator could be built for the Ising Hamiltonian in a nontrivial configuration, namely, for a large number of spins with multiple degrees of coupling.
The doubly excited 1 3Σ−g state of 7Li2 (1994)

This paper reports the first experimental observation of the doubly excited valence (2p+2p)3Σ−g state of 7Li2. We used cw perturbation-facilitated optical–optical double resonance (PFOODR) fluorescence excitation and resolved fluorescence spectroscopic techniques. All the observed levels have been detected through perturbations by the 2 3Πg state. The deperturbed primary molecular constants of this 1 3Σ−g state are Te=34 045.354(43) cm−1, ωe=216.820(37) cm−1, Be=0.673 69(47) cm−1, Re=2.670 81(94) Å, and De=4279.306(43) cm−1. The equilibrium internuclear distance of the 1 3Σ−g state is smaller than that of the X 1Σ+g ground state.
A Hybrid COA/ε-Constraint Method for Solving Multi-Objective Problems (2015)

In this paper, a hybrid method for solving multi-objective problem has been provided. The proposed method is combining the -Constraint and the Cuckoo algorithm. First the multi objective problem transfers into a single-objective problem using -Constraint, then the Cuckoo optimization algorithm will optimize the problem in each task. At last the optimized Pareto frontier will be drawn. The advantage of this method is the high accuracy and the dispersion of its Pareto frontier. In order to testing the efficiency of the suggested method, a lot of test problems have been solved using this method. Comparing the results of this method with the results of other similar methods shows that the Cuckoo algorithm is more suitable for solving the multi-objective problems.
A Newly Isolated Streptomyces sp. YYS-7 With a Broad-Spectrum Antifungal Activity Improves the Banana Plant Resistance to Fusarium oxysporum f. sp. cubense Tropical Race 4 (2020)

Fusarium wilt of banana caused by <i>Fusarium oxysporum</i> f. sp. <i>cubense</i> (Foc) is one of the most destructive diseases, severely limiting the development of banana industry. Especially, Foc tropical race 4 (Foc TR4) can infect and destroy almost all banana cultivars. Until now, there is still a lack of an effective method for controlling fusarium wilt. A biocontrol strategy using Actinobacteria is considered as a promising method for management of disease and pest. In this study, 229 Actinobacteria were isolated from rhizosphere soil samples of a primitive ecological mountain. An actinobacterium strain marked with YYS-7 exhibited a high antifungal activity against Foc TR4. Combining the physiological and biochemical characteristics as well as alignment of the 16S <i>rRNA</i> sequence, the strain YYS-7 was assigned to <i>Streptomyces</i> sp. The crude extracts of <i>Streptomyces</i> sp. YYS-7 obviously inhibited the mycelial growth of Foc TR4. The cell integrity and ultrastructure were seriously destroyed. In addition, <i>Streptomyces</i> sp. YYS-7 and crude extracts also showed a broad-spectrum antifungal activity against the selected seven phytopathogenic fungi. A gas chromatography-mass spectrometry (GC-MS) was used to predict the antifungal metabolites. A total of eleven different compounds were identified, including phenolic compounds, hydrocarbons, esters and acids. In the pot experiment, the crude extracts can significantly improve the banana plant's resistance to Foc TR4. Hence, <i>Streptomyces</i> sp. YYS-7 will be a potential biocontrol agent for the biofertilizer exploitation and the discovery of new bioactive substances.
Design of a Low Profile Antenna Considering the Thermal Properties (2019)

A compact and low profile antenna for aerocraft is presented in the paper. For the aerocraft application, not only the electrical properties but also the thermal properties should be considered in the antenna design. Full metal structure is used in the antenna design to meet the thermal requirement. C-shaped structure and shorting pins are used in the antenna design for the compact and low profile antenna design, which can reduce the antenna environment temperature because small size means the small wind resistance. The size of the antenna is only 0.19×0.09× 0.06 λ3, where λ is the center frequency.
Retinoid and bone metabolic marker in ossification of the posterior longitudinal ligament. (1998)

The pathogenesis of ossification of the posterior longitudinal ligament (OPLL) remains to be elucidated, though etiologic factors for OPLL have been identified. High levels of serum retinol and retinol binding protein (RBP) have been observed in patients with diffuse idiopathic skeletal hyperostosis (DISH). OPLL is often associated with DISH. In this study, the levels of serum retinol and RBP were determined in 70 patients with OPLL in the cervical spine, and compared with those in normal subjects. Bone metabolic markers of serum intact osteocalcin, urinary pyridinoline and deoxypyridinoline were examined as well. Among female patients, level of serum RBP was significantly higher in those in their 60's, and those with mixed type OPLL. Level of serum RBP was significantly higher in both sexes, and retinol was exhibited higher in female patients, if they were associated with DISH. Patients with OPLL exhibited no abnormal bone metabolic marker levels. These findings suggest that vitamin A may play a role in the development of OPLL.
Transoral Robotic Surgery (TORS (2010)

1. From the Robotics Lab to the Bedside Gregory S. Weinstein, Bert W. O'Malley, Jr. and Jason A. Diaz 2. Preoperative Evaluation Gregory S. Weinstein, Bert W. O'Malley, Jr., and Harry Quon 3. Instrumentation and Supplies Bert W. O'Malley, Jr. and Gregory S. Weinstein 4. Patient positioning and Room Setup Utilizing the da Vinci Robotic System- A Surgeon's Perspective Gregory S. Weinstein, W. Abuzeid, K. Khan, Bert W. O'Malley, Jr. 5. The Critical Role of the Operating Room Nursing Team Joseph W. Readinger, Samantha Davis, and Laura Kelchner 6. The Critical Roles of the Bedside Surgical Assistant: Optimizing Patient Safety and Achieving Hemostasis Neil G. Hockstein, Gregory S. Weinstein, Bert W. O'Malley, Jr. 7. Transoral Anatomy in the Context of TORS Niels Kokot, Bert W. O'Malley, Jr., Gregory S. Weinstein 8. Radical Tonsillectomy Gregory S. Weinstein, Bert W. O'Malley, Jr., and Harry Quon 9. Tongue Base Resection Bert W. O'Malley, Jr., Gregory S. Weinstein, W. Abuzaid, K. Khan, and Harry Quon 10. Supraglottic Partial Laryngectomy Gregory S. Weinstein, Bert W. O'Malley, Jr., W. Abuzaid, K. Khan, and Harry Quon 11. TORS for Parapharyngeal Space Tumors Bert W. O'Malley, Jr., Gregory S. Weinstein, Fernando D. Leonhardt, and Harry Quon 12. Tongue Base Reduction (TBR) and SupraGlottoPlasty (SGP) for Obstructive Sleep Apnea Claudio Vicini, Filippo Montevecchi, Giulia Tenti, Pietro Canzi, Iacopo Dallan and Erica Thaler 13. Glottic Procedures Bert W. O'Malley, Jr., Gregory S. Weinstein, W. Abuzaid, K. Khan, Harry Quon 14. Skull base TORS, Robotic Cranial Base Surgery and TORS Nasopharyngeal Resection Brad C. Lega, John Y.K. Lee, Jason G. Newman, M. Sean Grady, Gregory S. Weinstein, Bert W. O'Malley, Jr. 15. Postoperative Management: Optimizing Postsurgical Clinical Outcomes Bert W. O'Malley Jr., Gregory S. Weinstein, Ray Blanco, Dev Basu, and Shannon Murray 16. Special Considerations for Radiation Therapy Following TORS - Part 1 - Background and Rationale Harry Quon, Gregory S. Weinstein, and Bert W. O'Malley, Jr 17. Special Considerations for Radiation Therapy Following TORS - Part 2 - Current Treatment Approaches Harry Quon, Gregory S. Weinstein and Bert W. O'Malley, Jr. 18. Speech and Swallowing Rehabilitation following TORS Patricia K. Dooley and Lauren M. Campe 19. Surgical TeleMentoring: A Future Paradigm Shift in Surgical Education Bert W. O'Malley, Jr. and Gregory S. Weinstein
Trivalent Y3+ ionic sensor development based on (E)-Methyl-N′-nitrobenzylidene-benzenesulfonohydrazide (MNBBSH) derivatives modified with nafion matrix (2017)

(E)-Methyl-N'-nitrobenzylidene-benzenesulfonohydrazide (MNBBSH) compounds were synthesized using a condensation procedure from the derivatives of nitrobenzaldehyde and 4-Methyl-benzenesulfonylhydrazine, which crystallized in ethanol and methanol as well as characterized by FTIR, UV-Vis, <sup>1</sup>H-NMR, and <sup>13</sup>C-NMR. MNBBSH structure was confirmed using a single crystal X-ray diffraction technique and used for the detection of selective yttrium ion (Y<sup>3+</sup>) by I-V system. A thin layer of MNBBSH was deposited onto a glassy carbon electrode (GCE) with 5% nafion for the sensitive and selective Y<sup>3+</sup> sensor. The modified MNBBSH/GCE sensor is exhibited the better electrochemical performances such as sensitivity, limit of detection (LOD), linear dynamic range (LDR), limit of quantification (LOQ), short response time, and long term storage ability towards the selective metal ion (Y<sup>3+</sup>). The calibration curve of 2-MNBBSH/GCE sensor was plotted at +1.1 V over a broad range of Y<sup>3+</sup> concentration. Sensitivity, LOD, LDR and LOQ of the fabricated sensor towards Y<sup>3+</sup> were calculated from the calibration curve and found as 1.90 pAμM<sup>-1</sup> cm<sup>-2</sup>, 10.0 pM, 1.0 nM~1.0 mM and 338.33 mM respectively. The 2-MNBBSH/Nafion/GCE sensor was applied to the selective determination of Y<sup>3+</sup> in spiked samples such as industrial effluent and real water samples from different sources, and found acceptable and reasonable results.
Recent progress in non-fullerene small molecule acceptors in organic solar cells (OSCs) (2017)

The power conversion efficiencies (PCEs) of non-fullerene small molecule acceptors based on different donors have been compared and summarized.
ITI-007 in the treatment of schizophrenia: from novel pharmacology to clinical outcomes (2016)

ITI-007 is an investigational drug being developed for schizophrenia and other neuropsychiatric/neurodegenerative diseases. ITI-007 has a unique pharmacological profile, combining potent 5-HT2a receptor antagonism with cell-type-specific dopamine and glutamate receptor modulation, plus serotonin reuptake inhibition. At dopamine-D2 receptors, ITI-007 acts as a post-synaptic antagonist and pre-synaptic partial agonist. Additionally, ITI-007 stimulates phosphorylation of glutamatergic NMDA-NR2B receptors, downstream of dopamine-D1 receptor intracellular signaling. Based on a large, placebo and risperidone controlled, Phase-II trial, ITI-007 60 mg was shown to be effective in reducing symptoms in patients with acutely exacerbated schizophrenia. The antipsychotic efficacy of ITI-007 60 mg in this patient population was confirmed in a recently completed Phase III study. ITI-007 was associated with minimal safety risk compared to risperidone (Phase II study) or placebo (both studies) for neuromotor disturbances, prolactin changes, weight gain and metabolic abnormalities. A second 6-week, placebo and risperidone-controlled Phase-III trial in acutely exacerbated schizophrenia is ongoing.
Lateral resonances in 1–3 piezoelectric periodic composite: Modeling and experimental results (1997)

The objective of this work is to provide an accurate model of the lateral resonance modes in 1–3 piezoelectric composite materials. These materials are widely used in ultrasonic transducers and the lowest lateral mode frequency gives the upper limit for the usable transducer bandwidth. Considering the propagation of purely transverse waves in a 2-D periodic medium of infinite thickness, two different approaches for obtaining the solutions are presented and compared. The first approach is based on the use of the Bloch waves theory. The second is a straightforward method (a so-called membrane method) which consists in numerically solving the propagation equation in the two-phase medium while taking into account the periodic boundary conditions. Methods based on both models are described that allow the calculation of the dispersion curves and the stop band limits, as well as the frequencies and the displacement fields of the lateral modes. A test case is used to compare and discuss the theoretical predictions provided by each model. The calculations of the first lateral mode frequency are compared with experimental values obtained for samples with different ceramic volume fractions. The conclusion reached indicates that the infinite thickness assumption is valid for plates of practical interest and that the membrane model enables the prediction of lateral mode frequency with low computation effort and an accuracy better than 5%.
Calculating the dissociation constant of an unlabeled compound from the concentration required to displace radiolabel binding by 50%. (1982)

In order to determine the binding dissociation constant (KI) of a nonradiolabeled compound, the method of Cheng and Prusoff (1973) (Biochem. Pharmacol. 22, 3099-3108) has been widely employed. The technique involves monitoring the competitive displacement from receptors of a radiolabeled compound with a known dissociation constant, KD, by a nonradiolabeled compound. The concentration of nonradiolabeled compound which displaces 50% of the radiolabel, the IC50, is used to estimate its KI with correction for competition with the radiolabel. The error of this method is small as long as the concentration of receptor is much less than KD and KI, constraints which are sometimes difficult to meet. In this report formulae are derived from which KI can be calculated from IC50 with no constraints on the receptor concentration.
Bridging the information gap: A scoping review of radiation oncology patient education scholarship. (2019)

e23164 Background: Patient education (PE), the use of educational interventions to improve patient knowledge of healthcare, has been shown to reduce patient anxiety and facilitate shared decision making. In contrast to many other medical specialties, the state of radiation oncology (RO) PE is unclear. This scoping review aims to characterize the state of ROPE peer-review scholarship to describe strengths, identify gaps and guide future ROPE research. Methods: Predetermined medical subject headings and search terms were used to search PubMed for ROPE articles. Additional terms were identified from these articles and the search was repeated until no further articles were found. In-press articles in major RO and medical education (ME) journals were searched. English language articles published after 1/1/1990 that had a primary ROPE focus were included. Two independent reviewers performed the search and determined eligibility. Articles were categorized using the most predominant step of Kern’s six-step conceptual framework for ME curriculum development and the country and year of publication. Results: Of 11,756 identified articles, 182 met inclusion criteria. Articles per year increased over time (p &lt; 0.01): 1990-1994 (5.5%); 1995-1999 (11.0%); 2000-2004 (13.7%); 2005-2009 (10.4%); 2010-2014 (25.8%); 2015-2019 (33.5%). Conceptual framework categorization was as follows: problem identification (22.0%); needs assessment (23.6%); goals and objectives (4.9%); education strategies (9.9%); implementation (7.7%); evaluation and feedback (31.9%). Regional breakdown was as follows with some articles spanning regions: Africa (1.1%); South America (2.2%); Asia (6.0%); Australia (15.4%); Europe (30.2%); North America (45.6%). Conclusions: Nearly half of articles are primarily problem identification or needs assessment (45.6%) which are descriptive in nature and only identify or clarify ROPE needs. Additionally while these results are limited to English language scholarship, there are significant regional maldistributions. Although there is an encouraging trend of increasing ROPE publications over time, this study identifies opportunities to further develop, implement and evaluate ROPE scholarship.
Capillary Modification by Noncovalent Polycation Adsorption:  Effects of Polymer Molecular Weight and Adsorption Ionic Strength (1999)

The strong polycation poly(dimethyldiallylammonium chloride) (PDADMAC) was noncovalently immobilized on fused-silica capillaries. The stability and efficiency of the adsorbed coating was studied as a function of polymer molecular weight and coating ionic strength. By monitoring the electroosmotic flow on PDADMAC-coated capillaries, we found that optimal surface coverage is achieved using high molecular weight polycations at high ionic strength. Such capillaries can be used to elute positively charged proteins. In this study, true protein mobilities were obtained by (1) extrapolation of effective mobility to desired conditions and (2) theoretical calculation from the Henry function. By comparing apparent protein mobility with true protein mobility, we demonstrated that the protein−polycationic capillary surface interaction could enhance the selectivity of the silica capillary for separation of BSA and β-lactoglobulin.
Dielectric-based leaky-wave antenna for high gain using a printed surface-wave source (2010)

A multilayer leaky-wave antenna (LWA) is presented for microwave and millimetre-wave frequencies. By placing two superstrate dielectric layers on top of a base grounded dielectric slab, a practical resonant cavity structure can be realised for high gain at 17.39 GHz. The compact 6×6 cm LWA is fed by a printed surface-wave source integrated in the bottom ground plane. Measured gain values are greater than 11 dBi at broadside with half power beam less than 7°. The presented low cost and low profile LWA may be useful for radar applications and surveillance systems where lightweight and compact antenna designs are of interest.
Correlation between the magnitude of interlayer exchange coupling and charge-to-spin conversion efficiency in a synthetic antiferromagnetic system (2023)

Abstract The correlation between the magnitude of interlayer exchange coupling ( J ex ) and charge-to-spin conversion efficiency (spin Hall angle: θ SH ) is investigated in a synthetic antiferromagnetic (AF) system with compensated magnetization. The magnitude of θ SH increases linearly with increasing the magnitude of J ex . We observe the factor of 6.5 increase of spin Hall angle ( θ SH = 45.8%) in a low resistive ( ρ xx = 41 μ Ωcm) synthetic AF system by increasing the magnitude of J ex . The low resistive synthetic AF system will be a promising building block for future nonvolatile high-speed memories and logic circuits using the spin Hall effect.
Mechanism of ligand substitution in aluminum(III) complexes (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMechanism of ligand substitution in aluminum(III) complexesBrian J. Plankey and Howard H. PattersonCite this: Inorg. Chem. 1989, 28, 24, 4331–4333Publication Date (Print):November 1, 1989Publication History Published online1 May 2002Published inissue 1 November 1989https://doi.org/10.1021/ic00323a010RIGHTS & PERMISSIONSArticle Views180Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (390 KB) Get e-Alerts Get e-Alerts