gebhart/patrepeval huggingface dataset:
Correction to “Pyridine Ligand Rotation in Self-Assembled Trigonal Prisms. Evidence for Intracage Solvent Vapor Bubbles” (2016)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to "Pyridine Ligand Rotation in Self-Assembled Trigonal Prisms. Evidence for Intracage Solvent Vapor Bubbles"Jaroslav Vacek*, Douglas C. Caskey, Dominik Horinek, Richard K. Shoemaker, Peter J. Stang, and Josef Michl*Cite this: J. Am. Chem. Soc. 2016, 138, 20, 6688Publication Date (Web):May 11, 2016Publication History Published online11 May 2016Published inissue 25 May 2016https://pubs.acs.org/doi/10.1021/jacs.6b04606https://doi.org/10.1021/jacs.6b04606correctionACS PublicationsCopyright © 2016 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1029Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (128 KB) Get e-Alertsclose Get e-Alerts
An Electronic System for Ultra-low Power Hearing Implants (2013)

Abstract : We briefly summarize our key accomplishments during the grant period: These include the creation of bio-inspired systems that are important for improving speech intelligibility in noisy environments or for reducing noise exposure. They also include the creation of ultra-low-power electronics useful in portable hearing applications such as cochlear implants, hearing aids, hybrid hearing implants, intelligent personal protective equipment, and noise dosimeters. Together these accomplishments will be important in making miniature, intelligent hearing systems practical for many applications. The details are described in eight publications and three patents that are cited in the productivity section of this report.
(237) Chemical Mutagenesis in Snapdragon (Antirrhinum majus) (2006)

Seeds of Antirrhinum majus (snapdragon), proprietary line OAK564, were treated with 0%, 0.10%, 0.25%, 0.5%, 0.75%, and 1.0% ethyl methanesulfonate (EMS) for 8, 10, and 12 h at room temperature. The experiment was replicated three times over time. Data were collected on percent seed germination, seedling survivability, and pollen viability to determine optimal conditions for induced mutagenesis in OAK564 seeds. In the pilot experiment, M 1 seeds treated with 1.0% EMS for 12 h had the lowest seed germination rate among all 18 treatments. Based on this pilot experiment, a large-scale mutagenesis experiment was performed using three levels of EMS (0.5%, 0.75%, and 1.0%) for 10-h exposure period. Mutants were induced on all these treatments, and morphological changes in the M 1 population were detected. These included dwarfism, chlorophyll deficiency, and leaf morphology abnormality. This indicated that the EMS treatments were successful in inducing mutations, and mutants were further characterized for morphological traits.
A randomised experiment comparing low-cost ultrasound gel alternative with commercial gel (2016)

Images produced using the cornstarch-based alternative ultrasound gel were of similar quality to those using commercial gel. The low cost and easy preparation of the cornstarch-based gel make it an attractive coupling medium for use in low-resource settings.
An evolutionary conserved Hexim1 peptide binds to the Cdk9 catalytic site to inhibit P-TEFb (2016)

The positive transcription elongation factor (P-TEFb) is required for the transcription of most genes by RNA polymerase II. Hexim proteins associated with 7SK RNA bind to P-TEFb and reversibly inhibit its activity. P-TEFb comprises the Cdk9 cyclin-dependent kinase and a cyclin T. Hexim proteins have been shown to bind the cyclin T subunit of P-TEFb. How this binding leads to inhibition of the kinase activity of Cdk9 has remained elusive, however. Using a photoreactive amino acid incorporated into proteins, we show that in live cells, cell extracts, and in vitro reconstituted complexes, Hexim1 cross-links and thus contacts Cdk9. Notably, replacement of a phenylalanine, F208, belonging to an evolutionary conserved Hexim1 peptide (<sup>202</sup>PYNTTQFLM<sup>210</sup>) known as the "PYNT" sequence, cross-links a peptide within the activation segment that controls access to the Cdk9 catalytic cleft. Reciprocally, Hexim1 is cross-linked by a photoreactive amino acid replacing Cdk9 W193, a tryptophan within this activation segment. These findings provide evidence of a direct interaction between Cdk9 and its inhibitor, Hexim1. Based on similarities with Cdk2 3D structure, the Cdk9 peptide cross-linked by Hexim1 corresponds to the substrate binding-site. Accordingly, the Hexim1 PYNT sequence is proposed to interfere with substrate binding to Cdk9 and thereby to inhibit its kinase activity.
Photonic versus electronic quantum anomalous Hall effect (2017)

We derive the diagram of the topological phases accessible within a generic Hamiltonian describing quantum anomalous Hall effect for photons and electrons in honeycomb lattices in the presence of a Zeeman field and spin-orbit coupling (SOC). The two cases differ crucially by the winding number of their SOC, which is 1 for the Rashba SOC of electrons, and 2 for the photon SOC induced by the energy splitting between the TE and TM modes. As a consequence, the two models exhibit opposite Chern numbers $\ifmmode\pm\else\textpm\fi{}2$ at low field. Moreover, the photonic system shows a topological transition absent in the electronic case. If the photonic states are mixed with excitonic resonances to form interacting exciton-polaritons, the effective Zeeman field can be induced and controlled by a circularly polarized pump. This new feature allows an all-optical control of the topological phase transitions.
The Voice Conversion Challenge 2018: Promoting Development of Parallel and Nonparallel Methods (2018)

We present the Voice Conversion Challenge 2018, designed as a follow up to the 2016 edition with the aim of providing a common framework for evaluating and comparing different state-of-the-art voice conversion (VC) systems. The objective of the challenge was to perform speaker conversion (i.e. transform the vocal identity) of a source speaker to a target speaker while maintaining linguistic information. As an update to the previous challenge, we considered both parallel and non-parallel data to form the Hub and Spoke tasks, respectively. A total of 23 teams from around the world submitted their systems, 11 of them additionally participated in the optional Spoke task. A large-scale crowdsourced perceptual evaluation was then carried out to rate the submitted converted speech in terms of naturalness and similarity to the target speaker identity. In this paper, we present a brief summary of the state-of-the-art techniques for VC, followed by a detailed explanation of the challenge tasks and the results that were obtained.
Conceptual Model of Accounts - Closing the Gap between Financial Statements and Business Process Modeling (2014)

A comprehensive understanding of business processes is crucial for an in-depth audit of a company’s financial reporting and regulatory compliance. Recent major financial scandals impressively demonstrate the insufficiency of today’s audit methods. The most discussed method for improving the current state of things are process audits because well-controlled business processes lead to correct preparation, presentation, and disclosure of financial statements. In an attempt to improve the support of business process auditors, we present a conceptual model to close the gap between processes and their financial impacts. This conceptual model introduces accounts and associated booking-items making financial impacts visible. It is then integrated into the meta-model of a business process modeling language, namely the extended event-driven process chain. Moreover, this paper demonstrates an exemplary implementation with notational elements supporting the visualization of financial impacts. The paper ends with a questionnaire-based expert evaluation revealing that the proposed artifact is positively assessed overall.
NanoCluster Beacons as reporter probes in rolling circle enhanced enzyme activity detection (2015)

As a newly developed assay for the detection of endogenous enzyme activity at the single-catalytic-event level, Rolling Circle Enhanced Enzyme Activity Detection (REEAD) has been used to measure enzyme activity in both single human cells and malaria-causing parasites, Plasmodium sp. Current REEAD assays rely on organic dye-tagged linear DNA probes to report the rolling circle amplification products (RCPs), the cost of which may hinder the widespread use of REEAD. Here we show that a new class of activatable probes, NanoCluster Beacons (NCBs), can simplify the REEAD assays. Easily prepared without any need for purification and capable of large fluorescence enhancement upon hybridization, NCBs are cost-effective and sensitive. Compared to conventional fluorescent probes, NCBs are also more photostable. As demonstrated in reporting the human topoisomerases I (hTopI) cleavage-ligation reaction, the proposed NCBs suggest a read-out format attractive for future REEAD-based diagnostics.
Ultimate strength of carbon nanotubes: A theoretical study (2002)

The ultimate strength of carbon nanotubes is investigated by large-scale quantum calculations. While the formation energy of strain-induced topological defects determines the thermodynamic limits of the elastic response and of mechanical resistance to applied tension, it is found that the activation barriers for the formation of such defects are much larger than estimated previously. The theoretical results indicate a substantially greater resilience and strength, and show that the ultimate strength limit of carbon nanotubes has yet to be reached experimentally. Nanotubes are indeed the strongest material known.
Model-Based Robust Control of Directional Drilling Systems (2015)

To enable access to unconventional reservoirs of oil and (shale-) gas, geothermal energy and minerals, complex curved boreholes need to be drilled in the earth's crust. Directional drilling techniques, incorporating down-hole robotic actuation systems called rotary steerable systems, are used to generate these curved boreholes. In practice, however, boreholes drilled with such systems often show instability-induced borehole spiraling, which negatively affects the borehole quality and increases drag losses while drilling. As a basis for controller synthesis, we present a directional drilling model in terms of delay differential equations. Next, the problem of curved well-bore generation is formulated as a tracking problem and a model-based robust control strategy is developed, solving this tracking problem while guaranteeing the prevention of borehole spiraling. The effectiveness of the proposed approach is illustrated by representative case studies for the generation of curved boreholes.
Competitive antagonists of the corticotropin releasing factor (CRF) scanned with a i-(i+3) Glu Lys Bridge (2005)

CRF [1] is involved in a wide spectrum of central nervous system (CNS)-mediated effects, suggesting that this peptide plays an important role within the brain, especially in response to stressful stimuli [2]. Systematic SAR investigations have resulted in the development of CRF antagonists such as [3], members of the (standard) family [4] and conformationally restricted analogs [5] that are effective in the CNS. Those results, predictive methods and physicochemical measurements have suggested that CRF and its family members (urotensins and sauvagine) assume an conformation when interacting with the CRF receptors. To further test this hypothesis, we have scanned the whole rat/human sequence with an i-(i + 3) bridge consisting of the Glu-Xaa-Xbb-Lys scaffold which we and others had shown to be compatible with maintenance or enhancement of structure in at least some unpredictable cases.
Supplementary Materials from Targeting Pyruvate Kinase M2 Phosphorylation Reverses Aggressive Cancer Phenotypes (2023)

&lt;p&gt;This PDF file includes: Supplementary Materials and Methods, Supplementary Figures and Supplementary Tables&lt;/p&gt;
EFFECT OF GRAPEFRUIT JUICE ON CYCLOSPORINE PHARMACOKINETICS IN RENAL TRANSPLANT PATIENTS1 (1996)

This study investigated the effect of grapefruit juice on cyclosporine A (CsA) bioavailability in 10 renal transplant patients. Under CsA steady state conditions, patients were randomly administered their usual dose of CsA with either 8 ounces of grapefruit juice or 8 ounces of water. Using a crossover design, a 12-hr pharmacokinetic study was then conducted. Grapefruit juice increased the area under the concentration versus time curve (4218+/-1497 ng x hr/ml [grapefruit juice] vs. 3415+/-1288 ng x hr/ml [water], P=0.029) and 12-hr trough (244+/-214 ng x ml [grapefruit juice] vs. 132+/-56 ng x ml [water], P=0.09), but it did not change peak concentration (734+/-290 ng x ml [grapefruit juice] vs. 708+/-305 ng x ml [water], P=0.76). In addition, grapefruit juice delayed the time to peak concentration compared with water (5.4+/-3.0 hr [grapefruit juice] vs. 2.8+/-0.8 hr [water], P=0.025). These data suggest that concurrent administration of grapefruit juice with CsA will delay the absorption of CsA and increase the drug exposure of CsA without changing peak concentration.
Synthesis and antiinflammatory activity of copper 1-thioglycoses. (1988)

International audience
Calculation method for natural frequency of rotors considering load distribution in stepped parts (2022)

To improve the product performance of turbomachinery and ensure vibration reliability, we propose a method for predicting natural frequencies that considers the decrease in the stiffness of the rotor stepped part. We developed a modeling method that divides the stepped part into a conical part that is responsible for stiffness and a shoulder part that is modeled as an additional mass. We then formulated the stiffness of the conical element based on the static deformation considering the cross-sectional change and verified the stiffness for various conical beams. We also developed a method that determines the boundary between the conical part and the shoulder part based on the axial load distribution in the rotor when the tensile distribution load is applied to the small diameter part of the end face of the stepped part. The primary bending natural frequency under free-free conditions was evaluated for rotors with a large diameter part in the center and small diameter parts at both ends. The calculation accuracies using a conventional model composed of beam elements, a model that reproduces the conical stiffness parts with 100-divided beam elements, and a model using the formulated conical elements were compared and verified with the 3D FEM analysis results. Our findings showed that the stiffness calculation error of the conical element based on the static deformation was 2.81% or less. In addition, the natural frequency calculation error when modeling the stepped parts with the proposed conical elements was 2.3% or less, thus demonstrating that the natural frequency can be predicted accurately.
[Measurement of small bowel transit time in dogs with acetaminophen and indocyanine green]. (1992)

We developed an experimental method to measure the gastric and the small bowel transit times in dogs without using X-ray nor radioisotopes. The dog with the ileostomy was given food containing acetaminophen (APAP) and indocyanine green (ICG), then we sampled blood and ileal contents of the dog. We could measure the gastric transit time by detecting plasma APAP and the small bowel transit time by detecting ICG in the intestinal contents. Using this experimental system, we examined the times after feeding milk or solid meal. The gastric transit time after taking solid meal was longer than that after taking milk, but this difference was not significant, and the small bowel transit time after taking solid meal was significantly shorter than that after taking milk.
Baseline Correction of Spectra in Fourier Transform Infrared: Interactive Drawing with Bézier Curves (1998)

A baseline correction tool using the method of Bézier has been developed to permit the drawing of curves in a manner that allows full control of the line curvatures by the user. The basic concepts and principle of the Bézier algorithm are explained as well as the modifications that were made to take into account the limitations imposed by the treatment of spectral data. The application of this particular curve drawing routine to an existing baseline correction module offers facilities and extended capabilities that typical polynomial methods using least-squares fitted lines cannot attain. The examples of applications that are given demonstrate how this method can be performed, as well as its efficiency.
Glucosylceramide Synthesis Is Required for Basic Fibroblast Growth Factor and Laminin to Stimulate Axonal Growth (1997)

To test the hypothesis that neuronal growth requires the synthesis and supply of new membrane components to the growing neurite, we have examined the relationship between the synthesis of sphingolipids and the ability of two growth factors, basic fibroblast growth factor (bFGF) and laminin, to stimulate axonal growth in cultured hippocampal neurons. Both bFGF and laminin stimulate axonal growth by approximately fourfold; but the stimulatory effects of both factors can be abolished completely by two inhibitors of sphingolipid synthesis, fumonisin B1 and D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol. By using these inhibitors, together with two stereoisomers of short acyl chain derivatives of ceramide, only one of which is metabolized to glucosylceramide, we demonstrate that ongoing synthesis of glucosylceramide, the simplest glycosphingolipid, is a prerequisite for both bFGF and laminin to stimulate axon growth. These data imply that the ability of a growth factor to stimulate neuronal growth is dependent on the synthesis of an essential membrane lipid.
The orientation of a T cell receptor to its MHC class II:peptide ligands (1997)

The TCR found on CD4 T cells recognizes peptides bound to self MHC class II molecules as well as non-self MHC class II molecules. We have used the receptor on a cloned T cell line called D10.G4.1 (D10) to perform a structure-function analysis of this interaction. The D10 T cell clone recognizes not only a peptide from conalbumin (CA-wt) bound to syngeneic I-Ak against which it was raised, but also the allogeneic MHC molecules I-A(b,v,p,q,d). In the present study, we show that residue 30 in complementarity-determining region 1 (CDR1) of the TCR alpha-chain interacts with the I-A alpha-chain at hvr2 (residues 52, 53, and 55). We also show that residue 51 in CDR2 of the TCR alpha-chain interacts with the peptide at peptide residue 2. Finally, we show that residue 29 in CDR1 of the TCR beta-chain affects recognition of the glutamic acid at residue 66 in the I-A beta-chain. These data suggest an orientation of TCR relative to its peptide:MHC class II ligands. We argue that this orientation will be shared by all CD4 TCRs, and that it is only subtly different from the common orientation proposed for receptors binding to MHC class I.
Challenges of Additive Manufacturing of Electrical Machines (2019)

3D printing or additive manufacturing (AM) technology is considered an essential component of the Industry 4.0 revolution due to its improved capabilities over traditional manufacturing systems, facilitating the shift towards next generation smart factories. The three-dimensional fabrication freedom also suggests a new epoch in the design of electrical machines, as the process can finally be liberated from the constraints of 2D laminations. Despite the multi-material nature of 3D printing electrical machines, due to the availability and maturity of dedicated metal printing systems, most of the research and development on the field is concentrated on material optimization and rapid prototyping on these systems. In this paper we present the challenges of 3D printing electrical machines with current manufacturing systems and solutions offered by different authors. Challenges of selective laser melting (SLM) fabrication are discussed in greater detail due to its recognition and popularity in the electrical machine community.
Molecular Simulation of Carbon Dioxide, Brine, and Clay Mineral Interactions and Determination of Contact Angles (2014)

Capture and subsequent geologic storage of CO2 in deep brine reservoirs plays a significant role in plans to reduce atmospheric carbon emission and resulting global climate change. The interaction of CO2 and brine species with mineral surfaces controls the ultimate fate of injected CO2 at the nanoscale via geochemistry, at the pore-scale via capillary trapping, and at the field-scale via relative permeability. We used large-scale molecular dynamics simulations to study the behavior of supercritical CO2 and aqueous fluids on both the hydrophilic and hydrophobic basal surfaces of kaolinite, a common clay mineral. In the presence of a bulk aqueous phase, supercritical CO2 forms a nonwetting droplet above the hydrophilic surface of kaolinite. This CO2 droplet is separated from the mineral surface by distinct layers of water, which prevent the CO2 droplet from interacting directly with the mineral surface. Conversely, both CO2 and H2O molecules interact directly with the hydrophobic surface of kaolinite. In the presence of bulk supercritical CO2, nonwetting aqueous droplets interact with the hydrophobic surface of kaolinite via a mixture of adsorbed CO2 and H2O molecules. Because nucleation and precipitation of minerals should depend strongly on the local distribution of CO2, H2O, and ion species, these nanoscale surface interactions are expected to influence long-term mineralization of injected carbon dioxide.
Overall design concepts. (1964)

Manned spacecraft design concepts covering elements in space vehicle system, interrelation of systems and design management
Modified Clemmensen Reduction: Cholestane (2003)

Abstract Modified clemmensen reduction: cholestane product: cholestane byproduct: 3‐acetoxycholest‐2‐ene byproduct: cholestan‐3‐one
An electrostatic glass actuator for ultrahigh vacuum: A rotating light trap for continuous beams of laser-cooled atoms (2007)

This article describes the design, characterization, and performance of an electrostatic glass actuator adapted to an ultrahigh vacuum environment (10(-8) mbar). The three-phase rotary motor is used to drive a turbine that acts as a velocity-selective light trap for a slow continuous beam of laser-cooled atoms. This simple, compact, and nonmagnetic device should find applications in the realm of time and frequency metrology, as well as in other areas of atomic, molecular physics and elsewhere.