gebhart/patrepeval huggingface dataset:
A new method for continuous intraocular drug delivery (1989)

Abstract A novel device for the continuous intraocular delivery of drugs is described. The active intraocular component of the device is made from hollow haemodialysis fibres. During operation, the drug to be administered diffuses from a small extraocular reservoir to the intraocular fibres, where it passes through the semipermeable walls and into the vitreous body. The delivery of gentamicin by the device into the vitreous body of the cat is compared with direct intraocular injection techniques. Characteristics of the process of drug delivery were influenced by the geometry and design of the device. A reservoir concentration of 10 g/L gentamicin sulphate in a device with four fibres, each 5 mm long, resulted in stable vitreal gentamicin levels of 104 to 128 mg/L at 10 hours. Intravitreal injection of 0.1 ml of a 10 g/L solution of gentamicin caused localised peaks of intravitreal gentamicin concentration in the range 1180 to 3296 mg/L, before falling to 356 to 665 mg/L at 10 hours. The device provides the opportunity of a more controlled and continuous drug delivery, thus avoiding the high localised concentrations that may occur with direct injection techniques in which the required dose is delivered as a bolus. Refinement of a device of this type may result in a clinically useful method of intraocular drug delivery for drugs which present a risk of localised retinal toxicity or require repetitive administration with conventional intraocular injection techniques.
A MFKF Based SINS/DVL/USBL Integrated Navigation Algorithm for Unmanned Underwater Vehicles in Polar Regions (2019)

To conquer the high-accuracy navigation of Unmanned Underwater Vehicles (UUV) in polar regions, an integrated navigation algorithm based on the strapdown inertial navigation system (SINS) is proposed in this paper. Considering that the traditional SINS is based on the north-oriented geographic frame and will lose efficacy in polar regions because of the meridian convergence, the grid frame is employed to solve the problem of meridian convergence. Then the grid SINS still contains periodic oscillation errors and accumulated errors, so the Doppler velocity \log log (DVL) and ultra-short base line (USBL) are employed as the measurements to restrain the grid SINS errors and improve the navigation accuracy, and the grid SINS/DVL/USBL integrated navigation filter model is established. Finally, the DVL and the USBL have different update frequency and the sparse USBL output will decrease the estimation frequency and accuracy of the filter, and a multi-frequency Kalman filter (MFKF) is explored to maintain the high and stable update frequency and estimation accuracy. Simulation experiment results show that the proposed grid SINS/DVL/USBL integrated navigation algorithm can restrain the grid SINS errors effectively and navigate the UUVs in polar regions with high accuracy.
Selective hydrogenation of sunflower seed oil in a three‐phase catalytic membrane reactor (2001)

Abstract Continuous hydrogenation of sunflower seed oil has been carried out in a novel three‐phase catalytic membrane hydrogenation reactor. The membrane reactor consisted of a membrane impregnated with Pd as the active catalyst, which provided a catalytic interface between the gas phase (H 2 ) and the oil. Hydrogenations were carried out at different pressures, temperatures, and selectivities, and the formation of trans isomers was monitored during the hydrogenation runs. For the three‐phase catalytic membrane reactor, interfacial transport resistances and intraparticle diffusion limitations did not influence the hydrogenation reaction. Hydrogenation runs under kinetically controlled conditions showed that oleic and elaidic acid were not hydrogenated in the presence of linoleic acid. Initial formation of stearic acid was caused by direct conversion of linoleic acid into stearic acid by a shunt reaction. Furthermore, high selectivities led to high trans levels, which is in accordance with the many published data on hydrogenation of vegetable oils in slurry reactors. Finally, the catalytic membrane showed severe catalyst deactivation. Only partial recovery of the catalyst activity was possible.
Antenne PIFA bi-bande compacte pour l’IoT (2019)

Ce papier presente la conception d’une antenne PIFA (Planar Inverted F Antenna) bi-bande
compacte occupant une surface de 49 x 5 mm2 et couvrant les bandes de frequence 868 MHz et 915
MHz pour des applications IoT (Internet of Thing). Cette antenne, plus adaptee a une utilisation en
environnement electromagnetique complexe est constituee d’une branche metallique combinee a
une boucle chargee par une capacite de 1pF et placee sur un plan de masse de dimensions 120 x
60 mm². La conception et la simulation de l’antenne sont effectuees a l’aide du logiciel de simulation
electromagnetique HFSS. Un prototype a ete realise et mesure. Les parametres simules et mesures
ont montre une concordance.
Behaviour of ceria under hydrogen treatment: thermogravimetry and in situ X-ray diffraction study (1994)

Ceria reduction under hydrogen leads to a fluorite lattice expansion between 573 and 1073 K. Both bulk reduction of Ce4+ ions and insertion of hydrogen are thought to be responsible for this expansion in the 573–843 K temperature range.
Fusion of a camera and a laser range sensor for vehicle recognition (2009)

This paper presents a system that fuses data from a vision sensor and a laser sensor for detection and classification. Fusion of a vision sensor and a laser range sensor enables us to obtain 3D information of an object together with its textures, offering high reliability and robustness to outdoor conditions. To evaluate the performance of the system, it is applied to recognition of on-street parked vehicles scanned from a moving probe vehicle. The evaluation experiments show obviously successful results, with a detection rate of 100% and an accuracy over 95% in recognizing four vehicle classes.
Hsc70 regulates the nuclear export but not the import of influenza viral RNP: A possible target for the development of anti-influenza virus drugs. (2008)

In our previous report, we demonstrated that the matrix 1 (M1) protein of influenza virus directly binds to heat shock cognate protein 70 (Hsc70). The down-regulation of Hsc70 resulted in the reduction of influenza virus production, thus suggesting that Hsc70 plays a crucial role for viral replication. However, the detailed role of Hsc70 in viral replication remains to be elucidated. Hsc70 has been suggested to play a significant role in both the nuclear import and export processes. In this report, using leptomycin B (LMB), a CRM1-mediated nuclear export inhibitor, we demonstrated that Hsc70 forms a complex with vRNP through M1 in infected cells and in the virion, thus playing a significant role in the export of vRNP from the nucleus but not in the import of vRNP into the nucleus. The regulation of Hsc70 may therefore lead to the development of new anti-influenza virus drugs without raising mutant viruses.
Polystyrene‐Adsorbed Gangliosides for Investigation of the Structure of the Tetanus‐Toxin Receptor (1980)

This paper describes the elaboration, using cholera toxin and GM ganglioside as a model system, of versatile, sensitive methods allowing simple determinations of the specific binding of protein ligands to polystyrene‐adsorbed gangliosides, and, secondly, the application of these methods to the tentative identification of the receptor structure for tetanus toxin. The adsorption characteristics and the ligand‐binding properties of the adsorbed gangliosides were determined, and the specificity and sensitivity of the various ligand‐detection methods (radio‐isotope; enzyme‐linked antibody or water‐vapour condensation) defined. The adsorption did not vary with the type of ganglioside and was found to be linearly proportional to the square root of the incubation concentration and to the log of the incubation time. No difference in adsorption was seen between temperatures of 4 to 37 deg;C. As analyzed with cholera toxin, the polystyrene‐adsorbed ganglioside was structurally specific in binding; i.e. only GM1 was active while after hydrolysis by Vibrio cholerae sialidase also GD1a, GD1b and GT1b, for example, had the same activity as GM1. The affinity of cholera toxin for polystyrene‐adsorbed GM1 was similar to that for viable cells ( K a = 1.2 nM −1 ). Tetanus toxin was found to bind specifically to gangliosides of the G1b series (GD1b, GT1b and GQ1b) and though with less affinity, also to GT1a, GM1, GD1a and GD3. The binding affinity of tetanus toxin for the G1b gangliosides was less than that of cholera toxin for GM1. The studies showed that tetanus toxin has specific binding affinity for tetraose‐gangliosides with a disialosyl group linked to the inner galactose. It is conceivable that the natural binding structure for the tetanus toxin has the end sequence Galβ1 → 3Ga1NAcβ1 → 4Ga1(2← 8αNeuAc2 ← 3αNeuAc) which occurs in the ganglioside G1b series and possibly also in the oligosaccharide chains of certain cell membrane glycoproteins.
Surface Segregation and Chemical Ordering Patterns of Ag–Pd Nanoalloys: Energetic Factors, Nanoscale Effects, and Catalytic Implication (2014)

We performed Monte Carlo simulations to determine the roles of energetic factors and nanoscale effects in the surface segregation and chemical ordering patterns of Ag–Pd nanoalloy particles. Ag atoms significantly segregate onto the surface and preferentially occupy the low-coordinated sites, which significantly reduces the surface and strain energies of the nanoalloys. The segregation isotherms reveal that surface Ag composition is enhanced with increasing particle size or Ag concentration to circumvent the finite matter effects. Chemical ordering favored by attractive heterobonds can coexist and compete with surface segregation. Accordingly, small and Pd-rich nanoalloys display a continuous transition from Pd-core/mixing-shell to mixing-core/Ag-shell, where an ordered core is absent as a result of surface segregation and limited Ag supply. By contrast, large nanoalloys with equimolar or Ag-rich concentration exhibit the strong core ordering characteristics of bulk alloys. Particularly, surface patterns with partially alloyed facets and Ag-blocked vertices and edges are formed. This study also discussed the effects of isolating and blocking surface Pd active sites by Ag on the hydrogen evolution reaction and selective hydrogenation of acetylene.
Study on DMEA of Airplane System (2012)

The relevant definement,basic method,principle,program and main content of DMEA of airplane system are described in this paper.All of these could be the method of DMEA of military airplane system.
Synthesis of Nicotinoyl Hydrazones, Their /V-Oxide Analogues and the Corresponding 3-(5-Aryl- 1,3,4-oxadiazol-2-yl)pyridine Derivatives as Potential Hypoglycemic Agents (1992)

A series of nicotinoyl hydrazones and their /V-oxide analogues have been synthesized. Subsequent ring closure afforded the 3-(5-aryl-1,3,4-oxadiazol-2-yl)pyridine derivatives. The structures of the prepared compounds were established by means of spectral data. Fourteen of the hitherto prepared compounds, when screened on the albino rats at an oral dose of 100 mg/kg, reduced the blood sugar level to a significant extent. Oxadiazoles constitute one of the very significant classes of compounds which possess a variety of biological activity including antiinflammatory, bactericidal, fungicidal, herbicidal, analgesic, antiproteolytic, hypoglycemic, tranquilizing and CNS depressant [1 —9] properties. Recently, hydrazones have been found [10, 11] to be mildly active in producing hypoglycemia. The pharmacological activity associated with those hydrazones was at­ tributed [12] to the presence of -CONH-N=Cmoiety. In addition, /V-oxide derivatives usually have high polarity and consequently high solubility in aqueous solution which in turn facilitates their use for in vivo biological investigations. Perusal of literature revealed sufficient scope for further studies on the synthesis of new heterocyclic ring systems containing oxadiazole moiety via oxi­ dative cyclization of the corresponding hydrazones. Thus, in continuation of our research program [13— 17] directed for the synthesis of novel heterocycles of potential biological applications, we report herein on the synthesis of the previously unreported series of 3-(5-aryl-1,3,4-oxadiazol-2-yl)pyridine derivatives l/a— Ve and their /V-oxide analogues Via—Vie together with their precursors Ilia—Hie and IVa— IVe, respectively aiming to synthesize more potent and less toxic hypoglycemic agents.
FGF21 Maintains Glucose Homeostasis by Mediating the Cross Talk Between Liver and Brain During Prolonged Fasting (2014)

Hepatic gluconeogenesis is a main source of blood glucose during prolonged fasting and is orchestrated by endocrine and neural pathways. Here we show that the hepatocyte-secreted hormone fibroblast growth factor 21 (FGF21) induces fasting gluconeogenesis via the brain-liver axis. Prolonged fasting induces activation of the transcription factor peroxisome proliferator-activated receptor α (PPARα) in the liver and subsequent hepatic production of FGF21, which enters into the brain to activate the hypothalamic-pituitary-adrenal (HPA) axis for release of corticosterone, thereby stimulating hepatic gluconeogenesis. Fasted FGF21 knockout (KO) mice exhibit severe hypoglycemia and defective hepatic gluconeogenesis due to impaired activation of the HPA axis and blunted release of corticosterone, a phenotype similar to that observed in PPARα KO mice. By contrast, intracerebroventricular injection of FGF21 reverses fasting hypoglycemia and impairment in hepatic gluconeogenesis by restoring corticosterone production in both FGF21 KO and PPARα KO mice, whereas all these central effects of FGF21 were abrogated by blockage of hypothalamic FGF receptor-1. FGF21 acts directly on the hypothalamic neurons to activate the mitogen-activated protein kinase extracellular signal-related kinase 1/2 (ERK1/2), thereby stimulating the expression of corticotropin-releasing hormone by activation of the transcription factor cAMP response element binding protein. Therefore, FGF21 maintains glucose homeostasis during prolonged fasting by fine tuning the interorgan cross talk between liver and brain.
Pilot Study of Safety Belt Usability for Vehicle Occupants Seated in Wheelchairs (2005)

This study investigates the usability of wheelchair occupant restraint systems (WORS) that are used for crash protection of individuals seated in wheelchairs during motor vehicle transit. Ten independent adults with significant functional limitations who use wheelchairs for primary mobility were observed and interviewed while performing reach and manipulation tasks associated with WORS usage. Participants' opinions on ease of use and comfort-related factors were obtained for four occupant restraint scenarios. The study results show evidence of user problems with common WORS designs for use by wheelchair-seated individuals with significant functional limitations. Results from this pilot study suggest redesign of latch plates and buckles used in WORS to enable wheelchair-seated individuals with functional limitations to don and buckle belt restraints more easily and independently. Additionally, this study provides guidance to occupant-restraint manufacturers and wheelchair designers regarding belt-restraint usability. Improved WORS usability will complement other efforts to increase frequency of safety belt usage and lead to improved occupant safety.
Characterizing the Rheological and Bread-Making Properties of Wheat Flour Treated by “Gluten FriendlyTM” Technology (2021)

After discovering an innovative technology for the reshaping of gluten proteins-the "Gluten Friendly<sup>TM</sup>" system-that confers to wheat flour some unprecedented characteristics, such as reduced epitope antigenicity and a positive modulation of the gut microbiota, its effects on the production and quality of bread have been studied. Mainly, we have investigated the chemical, rheological and pasting properties of Gluten Friendly Flour (GFF) and of control flour (CF) with the aim of analyzing and interpreting potential differences. Furthermore, the bread made from GFF and CF was evaluated in terms of microstructure properties and sensory quality. The experiments demonstrated that GFF became soluble in aqueous solution, making it unfeasible to isolate using the Glutomatic apparatus. Although the water absorption of GFF increased by 10% compared to CF, dough elasticity was reduced, and dough stability decreased from 5 to 2 min. A significant increase in the alveograph index (P/L) from 0.63 to 6.31 was detected, whereas pasting properties did not change from the control flour. Despite these profound modifications in the rheological properties, GFF exhibited a high ability to shape dough and to produce bread with high quality and negligible differences from the control bread in terms of appearance, taste, aroma, color and texture.
Bluetooth Low Energy - privacy enhancement for advertisement (2014)

The aim of this project is to design, simulate, and implement a privacy enhancement protocol over BLE advertising channels. The design of the privacy enhancement is generic and modular. Due to the risk of privacy disclosure and device tracking by adversary, the main focus will be put on designing and implementing message confidentiality, replay prevention, and anti-tracking of device over BLE advertising channels. Bluetooth core specification 4.1 is used as baseline for design and implementation. In order to provide resistance against replay attacks and device tracking, this project has taken counter approach. It proposes a 3-way handshake protocol for nonce Rs deployment. There are two nonces Ra and Rs involved in the 3-way handshake protocol. The advertiser generates a nonce Ra as challenge sent to the scanner, which assures of freshness of the advertising session. Then the scanner generates a nonce Rs for advertising confidentiality and replay prevention. After the nonce Rs is deployed successfully from the scanner to the advertiser, the local counters Receiving (RX) and Transmitting (TX) on both sides are initialized to be Rs which protects all the following advertisement in the advertising session.To accommodate to open BLE advertising channels a handling mechanism of counter out-of-synchronization is given in system design. Moreover, to avoid unnecessary power consumption in the BLE devices then mitigation for Denial-of-service (DoS) is also proposed. In addition, advertising confidentiality, replay prevention, and antitracking of device have been simulated in Scyther and also been integrated into the code. The functional tests have been done in a realistic testing environment. The results show that the added functionalities work as designed.
Induction of phenazine biosynthesis in cultures of Pseudomonas aeruginosa by L-N-(3-oxohexanoyl) homoserine lactone (1996)

A range of Pseudomonas spp. and other Gram-negative bacteria were screened for induction of antimicrobial activity in response to the autoregulatory factor l-N-(3-oxohexanoyl)homoserine lactone. In one of these, P. aeruginosa ATCC 10145, the production of phenazine metabolites was shown to be inducible in a dose-dependent manner. The production of phenazine-1-carboxamide increased over 50-fold compared to control cultures when supplemented with 200 µg/ml of the autoregulator. In addition, the production of an unidentified polar antibacterial substance by this strain increased with autoregulator concentration.
Chondroitin 4- O -sulfation regulates hippocampal perineuronal nets and social memory (2023)

Glycan alterations are associated with aging, neuropsychiatric, and neurodegenerative diseases, although the contributions of specific glycan structures to emotion and cognitive functions remain largely unknown. Here, we used a combination of chemistry and neurobiology to show that 4-<i>O</i>-sulfated chondroitin sulfate (CS) polysaccharides are critical regulators of perineuronal nets (PNNs) and synapse development in the mouse hippocampus, thereby affecting anxiety and cognitive abilities such as social memory. Brain-specific deletion of CS 4-<i>O</i>-sulfation in mice increased PNN densities in the area CA2 (cornu ammonis 2), leading to imbalanced excitatory-to-inhibitory synaptic ratios, reduced CREB activation, elevated anxiety, and social memory dysfunction. The impairments in PNN densities, CREB activity, and social memory were recapitulated by selective ablation of CS 4-<i>O</i>-sulfation in the CA2 region during adulthood. Notably, enzymatic pruning of the excess PNNs reduced anxiety levels and restored social memory, while chemical manipulation of CS 4-<i>O</i>-sulfation levels reversibly modulated PNN densities surrounding hippocampal neurons and the balance of excitatory and inhibitory synapses. These findings reveal key roles for CS 4-<i>O</i>-sulfation in adult brain plasticity, social memory, and anxiety regulation, and they suggest that targeting CS 4-<i>O</i>-sulfation may represent a strategy to address neuropsychiatric and neurodegenerative diseases associated with social cognitive dysfunction.
Lignin-derived bio-based flame retardants toward high-performance sustainable polymeric materials (2020)

Lignin-derived flame retardants represent one of the most promising directions for next-generation flame retardants due to their sustainability, environmental benefits and comparable efficiency to current non-bio-based counterparts.
Comedication with interacting drugs predisposes amiodarone users in cardiac and surgical intensive care units to acute liver injury (2018)

Risk factors and underlying mechanisms for liver injury associated with amiodarone remain elusive. This study aimed to investigate the drug-related covariates for acute liver injury by amiodarone-an intriguing compound of high lipophilicity, with a long half-life and notable efficacy.The medical, pharmacy, and laboratory records of new amiodarone users admitted to the cardiac or surgical intensive care units of a medical center were examined retrospectively. A Cox regression model with time-varying dose-related variables of amiodarone was utilized to estimate the hazard ratio (HR) of amiodarone-associated liver injury while adjusting for concomitant therapy and relevant covariates.Of the 131 eligible patients among 6,572 amiodarone users (46,402 prescriptions), 6 were identified as amiodarone-associated liver injury cases. In comparison to controls (n = 125), this liver injury cohort (n = 6) had significantly higher numbers of amiodarone-interacting (2.7 ± 2.0 vs 0.9 ± 0.9 drugs, P = .02) and hepatotoxic (3.8 ± 0.8 vs 2.5 ± 1.7 drugs, P = .03) comedications. The number of comedications with amiodarone-interacting potential (HR 2.07, 95% confidence interval [CI] 1.02-4.22, P = .04) and amiodarone cumulative doses standardized by body surface area (HR 6.82, 95% CI 1.72-27.04, P = .01) were independent risk factors for liver injury associated with amiodarone.Drug-related (amiodarone cumulative dose, interacting drugs) factors were significant predictors of amiodarone-associated acute liver injury. A prudent evaluation of each medication profile is warranted to attain precision medicine at the level of patient care, especially for those treated by medications with complex physicochemical and pharmacokinetic properties, such as amiodarone.
Dual CDK4/CDK6 Inhibition Induces Cell-Cycle Arrest and Senescence in Neuroblastoma (2013)

Taken together, our data show that LEE011 is active in a large subset of neuroblastoma cell line and xenograft models, and supports the clinical development of this CDK4/6 inhibitor as a therapy for patients with this disease. Clin Cancer Res; 19(22); 6173-82. ©2013 AACR.