gebhart/patrepeval huggingface dataset:
Role Of Amphipathic α-Helical Structural Elements In Removing Cellular Cholesterol And Protecting Against Cardiovascular Disease (2007)

AbstractHigh-density lipoproteins (HDLs) protect against cardiovascular disease by removing cholesterol from arterial macrophages. One important pathway involves HDL apolipoproteins, which remove cellular cholesterol and phospholipids by an active process mediated by a cell membrane protein termed ATP-binding cassette transporter (ABC)A1. The interaction of apolipoproteins with ABCA1-expressing cells elicits several biological responses that coordinate removal of cellular lipids, including solubilizing membrane lipid domains, stabilizing ABCA1 protein and transducing signals. The apolipoprotein structural determinant responsible for all these activities is the amphipathic α-helix. Human and animal studies have shown that a reduced apolipoprotein supply and impaired macrophage ABCA1 activity are atherogenic. Metabolic factors associated with diabetes, the metabolic syndrome and inflammation can damage apolipoproteins and ABCA1, raising the possibility that impaired cholesterol removal from arterial cells contributes to the increased cardiovascular disease caused by these common disorders. These findings implicate amphipathic α-helical peptides as valuable therapeutic agents for treating cardiovascular disease.Key words: Atp-Binding Cassette Transporter A1Amphipathic HelixApolipoproteinsAtherosclerosisCardiovascular DiseaseCholesterolHigh-Density LipoproteinMacrophages
Splitting Vertices in 2-Layer Graph Drawings (2023)

Bipartite graphs model the relationships between two disjoint sets of entities in several applications and are naturally drawn as 2-layer graph drawings. In such drawings, the two sets of entities (vertices) are placed on two parallel lines (layers), and their relationships (edges) are represented by segments connecting vertices. Methods for constructing 2-layer drawings often try to minimize the number of edge crossings. We use vertex splitting to reduce the number of crossings, by replacing selected vertices on one layer by two (or more) copies and suitably distributing their incident edges among these copies. We study several optimization problems related to vertex splitting, either minimizing the number of crossings or removing all crossings with fewest splits. While we prove that some variants are \NP-complete, we obtain polynomial-time algorithms for others. We run our algorithms on a benchmark set of bipartite graphs representing the relationships between human anatomical structures and cell types.
Preparation and Characterization of a Micro-Supercapacitor with Three-Dimensional Microelectrode Arrays (2013)

With the development of the MEMS technology and the more widely-used micro-systems, micro-power devices are developed for portable consumer electronics. [ The MEMS supercapacitor is one of the most important parts for micro-powers. In this paper, a micro-supercapacitor was designed and fabricated with three-dimensional microelectrode arrays configuration. It has been tested by scanning electron microscopy, Cyclic Voltammeter, Galvanostatical charge/discharge curve and electrochemical impedance spectroscopy. These posts were 50 μm in diameter and 100 μm tall; with foot print area of 2×2mm 2 . The capacitance is 89.52mF/cm 2 . The biggest feature in this paper is that the two plates of the supercapacitor are both three-dimensional microelectrode arrays which are shown to offer significant advantages.
Figures S1-S3; Suppl Methods from <i>ATM</i> Loss Confers Greater Sensitivity to ATR Inhibition Than PARP Inhibition in Prostate Cancer (2023)

&lt;p&gt;Immunofluorescence and IR survival data; additional methods&lt;/p&gt;
Harmonization and Validation of Jiles–Atherton Static Hysteresis Models (2022)

The aim of the proposed paper is to harmonize the Jiles–Atherton (J–A) static hysteresis loop models presented by different authors at different publication dates. The reviewed papers, which explain the hysteresis loop model of magnetic materials originally developed by Jiles are taken into consideration due to their different variable nomenclature and even physical meaning. Inconsistency between Jiles’ referenced works is shown and the consequences are presented as differences between BH curve behaviors and, on the application level, as differences in calculated static hysteresis losses. The harmonization of J–A hysteresis models is presented and confirmed by numerical calculations and measured data.
Diesel Car Particulate Control Methods (1983)

&lt;div class="htmlview paragraph"&gt;Methods for particulate (and associated organics) emissions control were evaluated in several diesel cars. Of the methods investigated, only “particulate traps” provided large reductions in particulate emissions. Traps evaluated included metal mesh and ceramic monolithic configurations, catalyzed and uncatalyzed. One of the cars, with a ceramic trap installed, completed fifty thousand miles of distance accumulation. No significant deterioration of emissions occurred over those fifty thousand miles.&lt;/div&gt;
Preliminary Evidence for the Fibromyalgia Integrative Training Program (FIT Teens) Improving Strength and Movement Biomechanics in Juvenile Fibromyalgia (2020)

Objectives: Current therapies for juvenile fibromyalgia (JFM), such as cognitive-behavioral therapy (CBT), improve pain coping but are less effective for pain reduction or engagement in physical activity. The Fibromyalgia Integrative Training for Teens (FIT Teens) program combines CBT with specialized neuromuscular exercise training for adolescents with JFM. The current investigation examined the effects of FIT Teens versus CBT on secondary outcomes of strength and functional biomechanics, utilizing 3D Motion capture technology. This study aimed to explore improvements in strength and biomechanics in both a CBT-only group and the FIT Teens intervention. Materials and Methods: Forty adolescents with JFM (12 to 18 y) were randomized to an 8-week, group-based protocol of either FIT Teens or CBT only. Assessments occurred pretreatment and posttreatment. Hip and knee strength were assessed with dynamometry, dynamic postural stability was measured using the Star Excursion Balance Test, and movement biomechanics were assessed with 3D motion analyses during a drop vertical jump (DVJ) task. Results: The FIT Teens group exhibited improvements in hip abduction strength and greater external hip rotation during the DVJ task. Some differences between the FIT Teens and CBT groups were observed in peak hip internal moment in the transverse plane. Decreased hip adduction during the DVJ was also observed in the FIT Teens group. Discussion: Results suggest that the FIT Teens program shows promise in improving hip abduction strength and body biomechanics, indicating improvements in stability during functional movements. These improvements may facilitate ability to initiate and maintain regular physical activity in youth with widespread musculoskeletal pain.
The corneal topography of epikeratophakia. (1991)

Epikeratophakia is a surgical technique initially developed for the correction of aphakia, and later adapted for the correction of keratoconus and myopia. The concurrent development of color-coded computerized corneal topography has greatly assisted in the evolution of epikeratophakia. Corneal topography has demonstrated the importance of both accurate centration of the epikeratophakia lenticle over the visual axis and the size of the optical zone on the final refractive results. Corneal topographic changes associated with correction of aphakia are primarily the result of steepening of the anterior radius of curvature of the cornea, in contrast to myopic correction which results in flattening of the anterior cornea. Correction of keratoconus results from a physical compression of the cone thereby flattening both the anterior and posterior radii of curvature. Preoperative topography in patients with keratoconus permits the precise position and extent of both regular and irregular astigmatism mation may assist in designing the optimal lenticle size and amount of graft decentration necessary to achieve the maximal surgical effect. Corneal topographic mapping has also been helpful in the management of postoperative astigmatism following epikeratophakia. Topography identifies the location and extent of both regular and irregular astigmatism which assists in planning of both surgical and nonsurgical intervention. Corneal topographic mapping has also been extremely helpful in the management of postoperative astigmatism following epikeratophakia. Topography identifies the location and extent of both regular and irregular astigmatism which assists in planning of both surgical and nonsurgical intervention.
Transvenous Defibrillation Leads: High Incidence of Failure During Long‐Term Follow‐Up (2003)

Transvenous polyurethane ICD leads showed a high rate of lead insulation failure late after implantation with frequent inappropriate shock deliveries. Close follow-up is mandatory in patients with these leads. Automated device control features with patient alert function integrated into new devices may contribute to early detection of lead failure.
P2–004: Advantageous effect of deramciclane in the NaN3 model of Alzheimer's disease (2006)

Alzheimer's disease (AD) is the leading cause of dementia and patients suffer from severe cognitive impairment. Memantine is a low– to moderate–affinity uncompetitive N–methyl–D–aspartate receptor antagonist (NMDA) and is currently the only drug approved for use in the management of patients with moderate–to–severe Alzheimer's disease. It has been shown to improve cognitive functions in several pharmacological models of AD. Although the primary cause of AD is unknown, oxidative stress, bioenergetic impairment and mitochondrial failure have been implicated in its etiology. Impaired electron transport leads to decreased ATP production, formation of damaging free–radicals, causing excitotoxic damage, and neurodegeneration, which are specific to AD. It was also found that the selective damage of mitochondrial complex IV is present in post mortem AD brains. In our model the proper dose of sodium azide (NaN3) inhibited this complex by chronic administration (via subcutaneously implanted osmotic minipumps) in rats. Deramciclane is also a low–affinity uncompetitive NMDA receptor antagonist which can abolish increased glutamaterg activity associated with AD. In opened Ca2+ channels deramciclane indirectly inhibits Ca2+ overload of the neurons, to prevent apoptosis. Our goal was to illustrate the benefits of deramciclane on learning and memory functional disability in NaN3–treated rats. In our Alzheimer's model learning ability of NaN3–treated rats was significantly decreased compared to controls measured in Morris water maze (MWM). Animals receiving deramciclane (10 mg/kg/day) and memantine (5 mg/kg/day) intraperitoneally for 2 weeks, produced significant cognitive changes in MWM when memory functions were tested. It has been shown that only deramciclane improved the “time spent in the target area” significantly (p<0.01), while the ”latency to first crossing” was decreased and the “number of crossings” was increased significantly by both deramciclane and memantine, compared to the vehicle treated group (p<0.05 and p<0.01, respectively). The re–learning capability in the MWM was increased only by deramciclane (p<0.001). In the open field test at the beginning of the treatment, the spontaneous exploratory activity was reduced in the NaN3 treated animals but at the end of treatment both compounds increased significantly the total movement activity in treated animals.
Figure 1 from: Ivanova ES, Efeykin BD, Spiridonov SE (2021) The re-description of Synoecnema hirsutum Timm, 1959 (Synoecneminae, Ungellidae, Drilonematoidea) from a pheretimoid earthworm in Vietnam with the analysis of its phylogenetic relationships. ZooKeys 1076: 135-150. https://doi.org/10.3897/zookeys.1076.75932 (2021)

Figure 1 Synoecnema hirsutum Timm, 1959 A entire male B entire female C pharynx region of female D-E head region of females F egg. All in lateral position. Scales in µm.
Evaluating Carpet Appearance Loss: Surface Intensity and Roughness (1993)

Changes in the appearance of carpet pile due to mechanical wear may be evaluated with respect to changes in global image properties, i.e., those based on one-dimensional characterizations of the intensity surface. This paper describes the application of gray scale image analysis to the measurement of microtexture variation and roughness or relief. We attempt to characterize microtexture with intensity mean, variance, skewness, and spatial co-occurrence. Surface relief is quantified as normalized intensity area and fractal dimension. Our samples show that simple mechanical wear generally entails a loss of relief and variation, but carpet construction has an important effect on the observed trends. Intensity mean and fractal dimension are promising candidates for automated evaluation of carpet appearance.
Sorsby Fundus Dystrophy (1996)

Sorbsy fundus dystrophy (SFD) is an autosomal dominant disorder that is characterized by bilateral loss of central vision secondary to choroidal neovascularization and/or pigment epithelial atrophy in the macula, with onset of visual symptoms usually in the fourth or fifth decade. Drusenlike changes may occur, with impaired dark adaptation and abnormal electroretinographic results.
A clean slate 4D approach to network control and management (2005)

Today's data networks are surprisingly fragile and difficult to manage. We argue that the root of these problems lies in the complexity of the control and management planes--the software and protocols coordinating network elements--and particularly the way the decision logic and the distributed-systems issues are inexorably intertwined. We advocate a complete refactoring of the functionality and propose three key principles--network-level objectives, network-wide views, and direct control--that we believe should underlie a new architecture. Following these principles, we identify an extreme design point that we call "4D," after the architecture's four planes: decision, dissemination, discovery, and data. The 4D architecture completely separates an AS's decision logic from pro-tocols that govern the interaction among network elements. The AS-level objectives are specified in the decision plane, and en-forced through direct configuration of the state that drives how the data plane forwards packets. In the 4D architecture, the routers and switches simply forward packets at the behest of the decision plane, and collect measurement data to aid the decision plane in controlling the network. Although 4D would involve substantial changes to today's control and management planes, the format of data packets does not need to change; this eases the deployment path for the 4D architecture, while still enabling substantial innovation in network control and management. We hope that exploring an extreme design point will help focus the attention of the research and industrial communities on this crucially important and intellectually challenging area.
Low Ohmic Contact Resistancem-Plane AlGaN/GaN Heterojunction Field-Effect Transistors with Enhancement-Mode Operations (2010)

Low ohmic contact resistance m-plane AlGaN/GaN heterojunction field-effect transistors were demonstrated using a regrown n+-GaN contact layer. An ohmic contact resistance of 0.25 Ω·mm was obtained with an 80-nm-thick Si-doped regrown GaN contact layer deposited by metal organic chemical vapor deposition. Enhancement-mode m-plane AlGaN/GaN heterojunction field-effect transistors were demonstrated with a threshold voltage of +1.4 V and 2.0 mΩ·cm2 on-state resistances at +5 V of gate–source voltage.
Query Expansion and Query Fuzzy with Large-Scale Click-through Data for Microblog Retrieval (2019)

Searchers using microblog search often have difficulty in expressing their needs, they often struggle to modify queries by adding or removing terms, and this lead to unsatisfied experience. On the other hand, Microblogs content is limited in size, contain a few words and these will cause a real problem of term mismatch in microblog search.
Expression of a Rice Homeobox Gene Causes Altered Morphology of Transgenic Plants (1993)

Makoto Matsuoka, Hiroaki Ichikawa, Akira Saito, Yuichi Tada, Tatsuhito Fujimura, Yuriko Kano-Murakami, Expression of a Rice Homeobox Gene Causes Altered Morphology of Transgenic Plants, The Plant Cell, Vol. 5, No. 9 (Sep., 1993), pp. 1039-1048
Intragastric Infusion of Ethanol by Alcoholics After Surgery for Head and Neck Cancer (1992)

Alcohol abuse or dependence may complicate medical and surgical treatment. Two cases involving patients with head and neck cancer are presented to illustrate 1) continued drinking despite adverse medical consequences and 2) the need for careful assessment and appropriate intervention with alcohol‐dependent patients.
Total Synthesis of (±)-Deoxypenostatin A (1999)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTTotal Synthesis of (±)-Deoxypenostatin ABarry B. Snider and Tao LiuView Author Information Department of Chemistry, Brandeis University, Waltham, Massachusetts 02454-9110 Cite this: J. Org. Chem. 1999, 64, 4, 1088–1089Publication Date (Web):February 4, 1999Publication History Received27 October 1998Published online4 February 1999Published inissue 1 February 1999https://pubs.acs.org/doi/10.1021/jo982149nhttps://doi.org/10.1021/jo982149nrapid-communicationACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views635Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Aldehydes,Claisen rearrangement,Isomerization,Mixtures,Organic compounds Get e-Alerts
Endonuclease Restriction-Mediated Real-Time Polymerase Chain Reaction: A Novel Technique for Rapid, Sensitive and Quantitative Detection of Nucleic-Acid Sequence (2016)

The article reported a novel methodology for real-time PCR analysis of nucleic acids, termed endonuclease restriction-mediated real-time polymerase chain reaction (ET-PCR). Just like PCR, ET-PCR only required one pair of primers. A short sequence, which was recognized by restriction enzyme BstUI, was attached to the 5' end of the forward (F) or reverse (R) PCR primer, and the new F or R primer was named EF or ER. EF/ER was labeled at the 5' end with a reporter dye and in the middle with a quenching dye. BstUI cleaves the newly synthesized double-stranded terminal sequences (5' end recognition sequences and their complementary sequences) during the extension phase, which separates the reporter molecule from the quenching dye, leading to a gain of fluorescence signal. This process is repeated in each amplification cycle and unaffected the exponential synthesis of the PCR amplification. ET-PCR allowed real-time analysis of single or multiple targets in a single vessel, and provided the reproducible quantitation of nucleic acids. The analytical sensitivity and specificity of ET-PCR were successfully evaluated, detecting down to 250 fg of genomic DNA per tube of target pathogen DNA examined, and the positive results were generated in a relatively short period. Moreover, the practical application of ET-PCR for simultaneous detection of multiple target pathogens was also demonstrated in artificially contaminated blood samples. In conclusion, due to the technique's simplicity of design, reproducible data and low contamination risk, ET-PCR assay is an appealing alternative to conventional approaches currently used for real-time nucleic acid analysis.
[Researchers and psychiatrists defending Gillberg's research on ADDH: Karfve's campaign is a form of personal persecution and scientific basis is missing]. (2003)

[Researchers and psychiatrists defending Gillberg's research on ADDH : Karfve's campaign is a form of personal persecution and scientific basis is missing]
Activity of Plazomicin against Enterobacteriaceae Isolates Collected in the United States Including Isolates Carrying Aminoglycoside-Modifying Enzymes Detected by Whole Genome Sequencing (2017)

Abstract Background Plazomicin (PLZ) is a next-generation aminoglycoside (AMG) stable against aminoglycoside-modifying enzymes (AME) that completed Phase 3 studies for complicated urinary tract infections and serious infections due to carbapenem-resistant Enterobacteriaceae (ENT). We evaluated the activity of PLZ and AMGs against ENT collected in US hospitals during 2016. Methods A total of 2,097 ENT were susceptibility (S) tested by CLSI reference broth microdilution methods. E. coli, Klebsiella spp. Enterobacter spp., and P. mirabilis isolates displaying non-S MICs (CLSI criteria) for gentamicin (GEN), amikacin (AMK), and/or tobramycin (TOB) were submitted to WGS, de novo assembly and screening for AME genes. Results Against ENT, PLZ was more active than all 3 clinically available AMGs (Table). PLZ and AMK activities were stable regardless of the infection type; however, differences were observed for GEN and TOB. Bloodstream isolates displayed higher GEN MICs when compared with the other infection sites. TOB activity varied 4-fold, being higher for bloodstream and pneumonia infections and lower for skin/soft tissue and other/unknown specimens. Against 198 isolates carrying 1 or more AME-encoding genes detected among 208 AMG-non-S isolates, the activity of PLZ was 8- to 16-fold greater when compared with the activity of AMK and at least 16-fold higher than the activity of GEN or TOB. Conclusion PLZ was active against ENT isolates from US hospitals regardless of infection type. PLZ displayed activity against isolates carrying AME genes that represent 12.0% of selected species. AME-carrying isolates were considerably more resistant to AMK, GEN, and TOB, highlighting the potential value of PLZ to treat infections caused by these organisms. This project has been funded under BARDA Contract No. HHSO100201000046C. Disclosures M. Castanheira, Achaogen: Research Contractor, Research grant; L. M. Deshpande, Achaogen: Research Contractor, Research grant; C. M. Hubler, Achaogen: Research Contractor, Research grant; R. E. Mendes, Achaogen: Research Contractor, Research grant; A. W. Serio, Achaogen: Employee, Salary; K. M. Krause, Achaogen: Employee, Salary; R. K. Flamm, Achaogen: Research Contractor, Research grant
ChemInform Abstract: N‐Monoalkylation of Tetra‐O‐benzyl‐D‐arabinonamide: Synthesis of Some Open‐Chain Analogues of N‐Acetylneuraminic Acid and Their Evaluation as Sialidase Inhibitors. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.