gebhart/patrepeval huggingface dataset:
llamaOS: A Solution for Virtualized High-Performance Computing Clusters (2014)

For most use cases, the benefits of modern virtualization technologies vastly exceed the impact of the runtime computational overhead they introduce. However, for high-performance computing (HPC) systems, the additional overhead is often detrimental to critical elements of application performance. This work presents llamaOS (Low-LAtency Minimal Appliance Operating System) as a new approach to circumvent the overhead of virtualization and provide performance capabilities superior to even equivalent native (nonvirtual) systems. Within the llamaOS virtual environment, traditional system level services can be optimized for a specific target application domain. For example, a specialized networking framework, named llamaNET, is designed specifically for low-latency message passing communication. Performance studies show llamaNET provides a 70% reduction in network latency over native TCP for message sizes less than 8 kilobytes, while at the same time providing slightly higher communication throughput for larger sizes. This improvement in communication performance directly translates to overall application speedup for software that exhibits fine-grain parallelism.
Excimer laser with narrow linewidth and large internal beam divergence (1987)

An ordinary injection-locking system is modified such that the energy extracted from the line-narrowed oscillator is sufficient to lock a single-pass amplifier. A diffuser plate inserted between the oscillator and the amplifier increases the internal divergence to about 10 mrad. The performance of the system at 248 nm (KrF) is described.
Phototoxicity is not associated with photochemical tissue bonding of skin (2010)

PTB does not cause phototoxicity when used to repair skin wounds even though the RB concentration and 532 nm fluence in the mid-dermis during PTB are much greater than the LD(50) for RB phototoxicity in vitro. These results indicate that phototoxicity is not a concern when using PTB for tissue repair.
Endovascular Cannulation With a Microneedle for Central Retinal Vein Occlusion (2013)

We developed a new surgical treatment in which a microneedle is used for retinal endovascular cannulation to treat eyes with central retinal vein occlusion by flushing thrombus out of the central retinal vein as it passes through the lamina cribrosa. The eyes of 12 consecutive patients (12 eyes) with central retinal vein occlusion were successfully treated using this novel treatment. At 24 weeks after surgery, 9 of 12 eyes had gained more than 15 letters in best-corrected visual acuity, and the mean decrease in central foveal thickness was 271.1 μm. Few complications were observed. The microneedle is stiff and sharp enough to facilitate retinal endovascular cannulation in eyes with central retinal vein occlusion. This new technique is a promising treatment of macular edema due to central retinal vein occlusion.
The effects of a garlic oil chemical compound, propyl-propane thiosulfonate, on ruminal fermentation and fatty acid outflow in a dual-flow continuous culture system (2015)

The ban on the use of antibiotics as growth promoters in animal feeds in the European Union has stimulated research on potential alternatives. Recently, propyl-propane thiosulfonate (PTSO), a stable organosulfurate compound of garlic, was purified. The objectives of the current study were to investigate the potential effects of PTSO on rumen microbial fermentation and to define effective doses. Two experiments were conducted using dual-flow continuous culture fermenters in 2 replicated periods. Each experimental period consisted of 5 d for adaptation of the ruminal fluid and 3 d for sampling. Temperature (39°C), pH (6.4), and liquid (0.10 h(-1)) and solid (0.05 h(-1)) dilution rates were maintained constant. Samples were taken 2 h after feeding and from the 24-h effluent. Samples were analyzed for volatile fatty acids (VFA) and nitrogen fractions, and degradation of nutrients was calculated. In addition, 24-h effluents from experiment 2 were analyzed for their fatty acid (FA) profile. Treatments in experiment 1 included a negative control without additive, a positive control with monensin (12mg/L), and PTSO at 30 and 300mg/L. The addition of 30mg/L did not affect any of the measurements tested. The addition of 300mg/L reduced microbial fermentation, as suggested by the decreased total VFA concentration, true degradation of organic matter and acid detergent fiber, and a tendency to decrease neutral detergent fiber degradation. Experiment 2 was conducted to test increasing doses of PTSO (0, 50, 100, and 150mg/L) on rumen microbial fermentation. At 2 h postfeeding, total VFA and molar proportion of propionate responded quadratically, with higher values in the intermediate doses. Molar proportions of butyrate increased and branched-chain VFA decreased linearly as the dose of PTSO increased. In the 24-h effluents, total VFA, acetate, and branched-chain VFA concentrations decreased linearly and those of propionate responded cubically with the highest value at 100mg/L. Saturated FA decreased and unsaturated FA increased linearly with increasing dose of PTSO. The concentration of trans-10,cis-12 conjugated linoleic acid decreased by 78.5% with addition of PTSO at the highest dose (150mg/L). Results suggest the potential of PTSO to modify ruminal fermentation in a direction consistent with higher propionate molar proportion, higher outflow of unsaturated FA, and low trans-10,cis-12 conjugated linoleic acid in an effective dose between 50 and 100mg/L.
HPV sensitizes OPSCC cells to cisplatin-induced apoptosis by inhibiting autophagy through E7-mediated degradation of AMBRA1 (2020)

Oropharyngeal squamous cell carcinoma (OPSCC) is an increasing world health problem with a more favorable prognosis for patients with human papillomavirus (HPV)-positive tumors compared to those with HPV-negative OPSCC. How HPV confers a less aggressive phenotype, however, remains undefined. We demonstrated that HPV-positive OPSCC cells display reduced macroautophagy/autophagy activity, mediated by the ability of HPV-E7 to interact with AMBRA1, to compete with its binding to BECN1 and to trigger its calpain-dependent degradation. Moreover, we have shown that AMBRA1 downregulation and pharmacological inhibition of autophagy sensitized HPV-negative OPSCC cells to the cytotoxic effects of cisplatin. Importantly, semi-quantitative immunohistochemical analysis in primary OPSCCs confirmed that AMBRA1 expression is reduced in HPV-positive compared to HPV-negative tumors. Collectively, these data identify AMBRA1 as a key target of HPV to impair autophagy and propose the targeting of autophagy as a viable therapeutic strategy to improve treatment response of HPV-negative OPSCC.<b>Abbreviations</b>: AMBRA1: autophagy and beclin 1 regulator 1; CDDP: cisplatin (CDDP); FFPE: formalin-fixed paraffin-embedded (FFPE); HNC: head and neck cancers (HNC); HPV: human papillomavirus (HPV); hrHPV: high risk human papillomavirus (hrHPV); OCSCC: oral cavity squamous carcinomas (OCSSC); OPSCC: oropharyngeal squamous cell carcinoma (OPSCC); OS: overall survival (OS); qPCR: quantitative polymerase chain reaction; RB1: RB transcriptional corepressor 1; ROC: receiver operating characteristic curve (ROC).
Control of crystalline orientation of germanium by lateral graphoepitaxy on SiO2 microstructures (2005)

Control of crystalline orientation of germanium (Ge) on a SiO2 surface was demonstrated by lateral graphoepitaxy. An x-ray diffraction curve with a (400) peak was obtained in a Ge crystal grown on microholes, each of which has a side of 1μm long and four 10-nm-thick SiO2 sidewalls made from thermally oxidized Si {111} planes. Using this Ge crystal on the microholes as a seed crystal, a Ge crystal with a (400) orientation was laterally grown on a 10-nm-thick SiO2 layer, which was a thermally oxidized flat Si (100) surface, by zone melting.
Synthesis and Dimerization Studies of a Lipophilic Photoresponsive Aryl‐Extended Tetraurea‐Calix[4]pyrrole (2017)

We describe the syntheses of the lipophilic aryl-extended α,α,α,α-tetraurea-phenyl-calix[4]pyrrole 1, featuring four appended azo-phenyl groups with two tert-butoxy carbonyl meta-substituents and its photo-inactive counterpart 2. In CD<sub>2</sub> Cl<sub>2</sub> solutions, both tetraurea-calix[4]pyrroles self-assemble into dimeric capsules by encapsulating one molecule of a suitable bis-N-oxide or two molecules of a mono-N-oxide. The dimeric capsules are mainly stabilized by a cyclic array of sixteen hydrogen bonds established between the eight unidirectionally oriented urea groups. Photoirradiation experiments demonstrated the trans-to-cis isomerization of the azo-phenyl groups and the formation of a plethora of stereo isomeric cis-azo-enriched capsular assemblies. The highly cis-azo enriched capsular assemblies seem to show a reduced stability and their involvement in equilibria with non-capsular counterparts that also bind the N-oxides. The thermally induced cis-to-trans interconversion processes demonstrated the reversibility of the photoisomerization and the photostability of most binding partners. An equimolar mixture of the two tetraureas produced two homodimeric capsules and the heterodimeric counterpart in a ratio close to statistical distribution.
A state estimation method for photovoltaic power generation using independent component analysis (2011)

A large number of Photovoltaic Generations (PVs) are expected to be introduced in distribution systems (D/Ss). Therefore the state estimation is important problem for stable and reliable system operation. However, it is difficult to estimate the total power of PVs connected to a D/S because metering spots and metering items are limited in existing D/S. In this paper, we propose an estimation method for sum of PV-outputs connected to a D/S. This method enables to estimate PV-outputs by analyzing a power flow data which include PV-outputs and various distribution loads using independent component analysis (ICA). The estimation by ICA needs the same number of observation signals as estimation signals. So we propose the method which is able to estimate PV-outputs and load-changes from active and reactive power flow those are recognized as two observation signals measured at one observation point on distribution lines. And the information of insolation as a priori knowledge is added to the method improving the estimation accuracy.
Experimental Investigation on Surface Topography for PTMCs during High Speed Grinding (2013)

The present article deals with the surface topography during high speed grinding of particulate reinforced titanium matrix composites (PTMCs). Scanning electron microscopic images of the ground surface was analyzed. Combining the results presented in this paper, the following results could be summarized: (1) The reinforcing particles of PTMCs are removed by means of voids, pulled-out, fracture or crushed, and micro-cracks, which attributed to the plowing and shearing during high speed grinding. (2) The formation of the fracture pattern of PTMCs is formed due to the wear debris of the abrasion during high speed grinding.
Complete restoration of normal DNA repair characteristics in group F xeroderma pigmentosum cells by over-expression of transfected XPF cDNA (1998)

XP-F cDNA was cloned into a mammalian expression vector plasmid, and introduced into group F xeroderma pigmentosum (XP-F) cells. Several cell clones possessing transfected XPF cDNA were randomly isolated, and DNA repair characteristics of a clone, XP-FR2, were extensively analyzed. The XP-FR2 cells expressed high level of XPF protein as well as ERCC1 protein, although their parental XP-F cells expressed extremely low level of both proteins. The XP-FR2 cells showed UV resistance comparable to normal human cells, and had normal levels of UV-induced unscheduled DNA synthesis and normal capability to remove cyclobutane pyrimidine dimers and (6-4) photoproducts. Frequencies and types of UV-induced mutations examined by shuttle vector plasmids in XP-FR2 cells were similar to those in normal human cells. These results demonstrate that excision repair defect in XP-F cells is fully corrected by over-expression of XPF cDNA alone, although only partial correction of the cells by XPF cDNA has been reported before.
Power-Aware Cooperative Relay Selection Strategies in Wireless Ad Hoc Networks (2006)

Cooperative diversity is an effective technique to combat multipath fading. When this technique is applied to ad hoc networks, it is a key issue to design distributed and power-efficient relay selection strategies. In this paper, we propose the power-aware relay selection (PARS) strategies to maximize the network lifetime. The PARS strategies are composed of the optimal power allocation(OPA) and three power-aware selection criteria. The OPA aims at minimizing the overall transmit power, while the three criteria select the relay that best help extend the network lifetime, based on both the OPA results and the residual power levels of the nodes. We combine our strategies with the opportunistic relay model, which is based on a 802.11b-like media access control (MRC) protocol, so the selection process can be done in a totally distributed way. Simulation results show that the proposed strategies have great improvement in both network lifetime and power efficiency
Is 60 FPS better than 30? (2014)

We present a pilot study investigating the relationship between frame rate and latency and their effects on moving target selection. In several latency/frame rate conditions, participants were given a 20 second time frame to click as many moving targets as possible. Performance with 60 FPS frame rate was 14% higher than 30 FPS, but the difference between 45 and 60 FPS was not significant. Latency alone had lower impact than the corresponding frame rate difference. While both factors impact performance, frame rate had a larger effect than the latency it introduces.
Charakterisierung der Systeme zur Ermittlung der Fourier- Transformation (1997)

This paper deals with the characterization of all systems needed to calculate the Fourier-Transform of a given signal. The procedure to classify these systems is given. One main part of the paper describes the practical application of the procedure. The well known sinc-function plays a significant role in the investigations. The advantages of the technique of this paper are also discussed.
Carrier Medium Exchange through Ultrasonic Particle Switching in Microfluidic Channels (2005)

This paper describes a method, utilizing acoustic force manipulation of suspended particles, in which particles in a laminar flow microchannel are continuously translated from one medium to another with virtually no mixing of the two media. During the study, 5-microm polyamide spheres suspended in distilled water, spiked (contaminated) with Evans blue, were switched over to clean distilled water. More than 95% of the polyamide spheres could be collected in the clean medium while removing up to 95% of the contaminant. Preliminary experiments to use this method to wash blood were performed. Red blood cells were switched from blood, spiked with Evans blue, to clean blood plasma. At least 95% of the red blood cells (bovine blood) could be collected in clean blood plasma while up to 98% of the contaminant was removed. The obtained results indicate that the presented method can be used as a generic method for particle washing and, more specifically, be applied for both intraoperative and postoperative blood washing.
Training classifiers with limited data using the Radon cumulative distribution transform (2018)

Our purpose in this study is to investigate whether a recently introduced image transform, denoted as the Radon cumulative distribution transform (R-CDT), can be used as a viable preprocessing step for augmenting the robustness of training end-to-end systems with fewer training samples. In order to assess the ability of the R-CDT to perform this aim, we identified a standard machine learning dataset, MNIST, and a preliminary dataset comprised of liver cell nuclei images derived from one of two tissue types: benign or malignant tumor lesions. We separated the data into training and testing sets with 20% of the total data used for testing across all training set size conditions. To simulate a range of limited size of training examples, we randomly generated data subsets ranging in size from 80% to 0.8% of the total dataset size to be used for training. Linear classification algorithms were implemented via logistic regression and a support vector machine model with a linear kernel on both the raw images and images transformed via the R-CDT. Additionaly, non-linear classification accuracies were assessed via comparing the R-CDT paired with a shallow CNN and using a deep CNN to classify images. Results indicate that classification in Radon cumulative distribution transform space outperforms classification in image space in conditions of limited data, as one is likely to see in medical imaging.
A Scalable Low-Voltage Signaling (SLVS) Driver for a Low-Power MIPI M-PHY Serial Link in 40 nm CMOS (2012)

This paper presents the design and simulations of a scalable low-voltage signaling (SLVS) type output driver for a MIPI M-PHY serial link. The specified data rate is 5.8 Gb/s at the maximum, which makes particularly the pre-driver design challenging. The link is targeted for battery-powered mobile applications. Therefore, a low power budget is an important issue and makes use of CMOS logic for the pre-driver most attractive. Minimizing the common-mode interferences at the output is crucial for acceptable low electromagnetic coupling from the serial link. In addition to the output driver, two other key blocks are considered. A low-dropout voltage (LDO) regulator provides the supply voltage (200-400 mV) for the driver. A sense amplifierbased flip-flop (SAFF) is utilized as the pre-driver to synchronize the data to be sent. Simulations show correct operation of the output driver and SAFF at 5.80-Gb/s with a low enough commonmode content in the output spectrum, while consuming total power (the LDO, SAFF and driver) of 2.4 mW.
Less is More: End-to-end Learning of Insights from a Single Motion Sensor for Accurate and Explainable Soccer Goalkeeper Kinematics (2021)

&lt;div&gt;On-field sensor-based soccer player tracking solutions are emerging and provide new insights into the dynamics of the player during training or a match. Yet, not all player positions are equally privileged. Goalkeepers’ training and performance assess- ment were for a long time ignored. Understanding what is ”the side of the post where most high dives were performed” provides valuable input for both the trainer and the athlete to improve perfor- mance or avoid injuries. In the current study, we focus on a practical methodology to extract insights from goalkeeper kinematics to inform such analytics. We demonstrate that information from a single motion sensor can be successfully used for learning patterns in goalkeeper’s motion and provide an explainable goalkeeper kine- matics assessment. We employed raw and quaternions data and we evaluated a series of machine learning algorithms that discriminate dive types (i.e. binary classification) and dives from other types of specific motions (i.e. multi-class classification) directly from the data. Our results demonstrate that XGBoost outperforms other approaches in terms of performance when considering both raw and quaternions, essentially benefiting from both types of data. Additionally, each prediction of the model is accompanied by an explanation of how each sensed motion component contributes to describing a specific goalkeeper’s action captured by the model. The explainable predictions along with the efficient deployment of XGboost were decisive in our applied study. We evaluated our methodology on a first batch of experiments using online available data from 7 goalkeepers during 30 minutes-long training sessions.&lt;br&gt;&lt;/div&gt;
Rheumatoid factor positivity rather than anti-CCP positivity, a lower disability and a lower number of anti-TNF agents failed are associated with response to rituximab in rheumatoid arthritis (2009)

RF-positive rather than anti-CCP-positive RA patients with lower baseline disability and a lower number of previously failed TNF blockers may be the best candidates to RTX.
A Systematic Review of the Mechanisms Involved in Immune Checkpoint Inhibitors Cardiotoxicity and Challenges to Improve Clinical Safety (2022)

Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that block CTLA-4, PD-1, or PD-L1 and induce the activation of the immune system against cancer. Despite the efficacy of ICIs, which has improved the oncotherapy for patients with a variety of malignancies, several immune-related adverse events (irAEs) have been described, including those affecting the heart. Cardiac irAEs after ICI therapies, including myocarditis, can become life-threatening, and their pathogenic mechanisms remain unclear. Here, a systematic analysis was performed regarding the potential immune mechanisms underlying cardiac irAEs based on the immune adverse events induced by the ICIs: 1) recruitment of CD4<sup>+</sup> and CD8<sup>+</sup> T cells, 2) autoantibody-mediated cardiotoxicity, and 3) inflammatory cytokines. Furthermore, the impact of dual therapies in ICI-induced cardiac irAEs and the potential risk factors are reviewed. We propose that self-antigens released from cardiac tissues or cancer cells and the severity/advancement of cancer disease have an important role in ICI cardiotoxicity.
Synthesis of Nitroxy-Functionalized Polybutadiene by Anionic Polymerization Using a Nitroxy-Functionalized Terminator (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTSynthesis of Nitroxy-Functionalized Polybutadiene by Anionic Polymerization Using a Nitroxy-Functionalized TerminatorSeiya Kobatake, H. James Harwood, Roderic P. Quirk, and Duane B. PriddyView Author Information Maurice Morton Institute of Polymer Science, The University of Akron, Akron, Ohio 44325-3909 Designed Thermoplastics Research, The Dow Chemical Company, Midland, Michigan 48667 Cite this: Macromolecules 1997, 30, 14, 4238–4240Publication Date (Web):July 14, 1997Publication History Received4 February 1997Published online14 July 1997Published inissue 1 July 1997https://doi.org/10.1021/ma970153fCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views423Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (118 KB) Get e-AlertscloseSUBJECTS:Anionic polymerization,Carbene compounds,Functionalization,Mixtures,Polymers Get e-Alerts