gebhart/patrepeval huggingface dataset:
Model for the Calculation of the Concentration of Dissolved Hematite during Hydrogen Peroxide Leaching of Iron Oxide Ore (2009)

Model for the calculation of the concentration of dissolved haematite during hydrogen peroxide leaching of iron oxide ore has been derived. The model was found to depend on both the % concentration of dissolved iron and weight input of iron oxide ore from experiment. The validity of the model is rooted on the expression %Fe 2 O 3 %Fe() 1/3 where both sides of the relationship are correspondingly almost equal. The deviation of the model-predicted concentration of dissolved haematite from the corresponding experimental values is less than 30% which is quite within the acceptable range of deviation limit of experimental results. The model indicates that the dissolved % ratio of extreme oxidation stage of iron to that of its extreme reduction stage is approximately equal to one-sixth (1/6th) power of the weight input of iron oxide ore during the leaching process.
A Comparison of the Immune Performance of a 1991 Commercial Broiler with a 1957 Randombred Strain When Fed “Typical” 1957 And 1991 Broiler Diets (1994)

The general objective of the present study was to assess the contribution that changes in genetic selection and dietary regimen have made on the immune performance of broilers. Chicks were hatched from 1991 and 1957 strains and placed on diets thought to be typical of those fed during 1957 and 1991. Immune responses were measured as total, IgM, and IgG antibody production, macrophage, and natural killer (NK) cell functions. Significant differences were observed between strains in antibody production. For example, 1957 males fed 1957 diets had the highest total (P < .0001), IgM (P < .0016), and IgG (P < .015) anti-sheep red blood cell antibodies as compared with all other strain-diet-sex groups. Both strains behaved similarly in terms of inflammatory macrophage recruitment, substrate adherence potential, and in the phagocytosis of sheep red blood cells. A greater percentage of the 1991 strain birds exhibited NK cell activity than all other groups. These studies suggest that genetic selection towards enhanced performance traits has negatively influenced the adaptive arm of the immune system (antibody production) with little or no effect on the nonadaptive components (macrophage and NK functions).
Efficiency Optimization of a 100-W 500 000-r/min Permanent-Magnet Machine Including Air-Friction Losses (2009)

This paper proposes a method for the efficiency optimization of ultrahigh-speed permanent-magnet machines. Analytical methods are applied for the modeling of the machine that is equipped with a diametrically magnetized rotor and a slotless stator. The outer dimensions of the machine are design constraints, and the internal dimensioning is optimized for minimum losses. The air-friction losses are taken into account in addition to the usual iron, copper, and eddy-current losses. Laminated silicon-iron or laminated amorphous iron is used as the stator core material. The results show that air-friction losses influence the optimum design considerably, leading to a small rotor diameter at high speeds. The loss minimization and the amorphous iron core make it possible to reduce the calculated losses by 63% as compared to a machine design not considering air-friction losses. The resulting efficiency is 95% for a 100-W 500 000-r/min machine excluding bearing losses. Experimental results are shown to illustrate the validity of the method.
An Automata Based Intrusion Detection Method for Internet of Things (2017)

Internet of Things (IoT) transforms network communication to Machine-to-Machine (M2M) basis and provides open access and new services to citizens and companies. It extends the border of Internet and will be developed as one part of the future 5G networks. However, as the resources of IoT’s front devices are constrained, many security mechanisms are hard to be implemented to protect the IoT networks. Intrusion detection system (IDS) is an efficient technique that can be used to detect the attackers when cryptography is broken, and it can be used to enforce the security of IoT networks. In this article, we analyzed the intrusion detection requirements of IoT networks and then proposed a uniform intrusion detection method for the vast heterogeneous IoT networks based on an automata model. The proposed method can detect and report the possible IoT attacks with three types: jam-attack, false-attack, and reply-attack automatically. We also design an experiment to verify the proposed IDS method and examine the attack of RADIUS application.
Assays for Radiolabel-Photoaffinity Labeling of Angiotensin Receptors (2003)

Photoaffinity labeling is a useful method to covalently bind two interacting moieties whether they be substrate and enzyme or ligand and receptor. Irreversibly labeling any particular molecule is a practical way of detecting the latter throughout the course of a characterization or a purification procedure.
Hardware works, software doesn't: enforcing modularity with Mondriaan memory protection (2003)

Classically, single-phase isotropic elastic (IE) model has been used for in situ or in vivo indentation analysis of articular cartilage. The model significantly simplifies cartilage structure and properties. In this study, we apply a fibril-reinforced poroelastic (FRPE) model for indentation to extract more detailed information on cartilage properties. Specifically, we compare the information from short-term (instantaneous) and long-term (equilibrium) indentations, as described here by IE and FRPE models. Femoral and tibial cartilage from rabbit (age 0-18 months) knees (n=14) were tested using a plane-ended indenter (diameter=0.544 mm). Stepwise creep tests were conducted to equilibrium. Single-phase IE solution for indentation was used to derive instantaneous modulus and equilibrium (Young's) modulus for the samples. The classical and modified Hayes' solutions were used to derive values for the indentation moduli. In the FRPE model, the indentation behavior was sample-specifically described with three material parameters, i.e. fibril network modulus, non-fibrillar matrix modulus and permeability. The instantaneous and fibril network modulus, and the equilibrium Young's modulus and non-fibrillar matrix modulus showed significant (p<0.01) linear correlations of R(2)=0.516 and 0.940, respectively (Hayes' solution) and R(2)=0.531 and 0.960, respectively (the modified Hayes' solution). No significant correlations were found between the non-fibrillar matrix modulus and instantaneous moduli or between the fibril network modulus and the equilibrium moduli. These results indicate that the instantaneous indentation modulus (IE model) provides information on tensile stiffness of collagen fibrils in cartilage while the equilibrium modulus (IE model) is a significant measure for stiffness of PG matrix. Thereby, this study highlights the feasibility of a simple indentation analysis.
Mutual information upper bound of molecular communication based on cell metabolism (2016)

Synthetic biology is providing novel tools to engineer cells and access the basis of their molecular information processing, including their communication channels based on chemical reactions and molecule exchange. Molecular communication is a discipline in communication engineering that studies these types of communications and ways to exploit them for novel purposes, such as the development of ubiquitous and heterogeneous communication networks to interconnect biological cells with nano and biotechnology-enabled devices, i.e., the Internet of Bio-Nano Things. One major problem in synthetic biology stands in the development of reliable techniques to control the engineered cells from the external environment. In this paper, molecular communication concepts are applied to study the potential of cell metabolism, and its regulation, to serve this purpose. In particular, a communication system abstraction is introduced to obtain a binary encoder model of the mechanisms underlying the regulation of the chemical reactions activity within the cell metabolism in function of the chemical composition of the external environment. Stemming from this model, an upper bound to the information theoretic mutual information is obtained through the use of a well-known and computationally efficient metabolic simulation technique. This upper bound stands as a theoretical limit of the ability of a particular cell to internally represent the information contained in the chemical composition of the external environment. Numerical results related to the metabolism of the E. coli bacterium are presented to evaluate the proposed approach.
Cellular affinity of polyamides having various functional groups. I. Platelet adhesion (1981)

Abstract Various polyamides having a different density of hydrogen bonding, of hydrophilic character, and containing ionic groups have been synthesized and their blood compatibilities were evaluated in terms of the adhesion behavior of blood platelets on polyamide by the microsphere column method. Polyamides containing anionically charged groups such as carboxylate or sulfonate groups adsorbed fewer blood platelets than those with undissociated carboxylate groups. Polyamides having thioether groups adsorbed fewer platelets than those having ether groups. Introduction of a rigid piperazine unit caused an increase in platelet adhesion.
Model consent form for psychiatric drug treatment (1998)

Given the notorious lack of informed consent in the practice of psychiatry and a tendency to use typical consent forms to protect professionals rather than inform or empower patients, the authors propose a “model consent form” for psychiatric drug treatment. This form seeks to highlight the dubious nature of medical knowledge about psychological problems diagnosed and treated, to describe regulatory processes that result in truncated knowledge about prescribed drugs, and to present realistic and understandable information about somatic and psychological effects of drug use and drug withdrawal.
Interaction between inducible nitric oxide synthase and cyclooxygenase-2 after cerebral ischemia (1998)

Focal cerebral ischemia is associated with expression of both inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), enzymes whose reaction products contribute to the evolution of ischemic brain injury. We tested the hypothesis that, after cerebral ischemia, nitric oxide (NO) produced by iNOS enhances COX-2 activity, thereby increasing the toxic potential of this enzyme. Cerebral ischemia was produced by middle cerebral artery occlusion in rats or mice. Twenty-four hours after ischemia in rats, iNOS-immunoreactive neutrophils were observed in close proximity (<20 micrometer) to COX-2-positive cells at the periphery of the infarct. In the olfactory bulb, only COX-2 positive cells were observed. Cerebral ischemia increased the concentration of the COX-2 reaction product prostaglandin E2 (PGE2) in the ischemic area and in the ipsilateral olfactory bulb. The iNOS inhibitor aminoguanidine reduced PGE2 concentration in the infarct, where both iNOS and COX-2 were expressed, but not in the olfactory bulb, where only COX-2 was expressed. Postischemic PGE2 accumulation was reduced significantly in iNOS null mice compared with wild-type controls (C57BL/6 or SV129). The data provide evidence that NO produced by iNOS influences COX-2 activity after focal cerebral ischemia. Pro-inflammatory prostanoids and reactive oxygen species produced by COX-2 may be a previously unrecognized factor by which NO contributes to ischemic brain injury. The pathogenic effect of the interaction between NO, or a derived specie, and COX-2 is likely to play a role also in other brain diseases associated with inflammation.
Considerations in implementing canary based prognostics (2015)

The concept of using canary devices to predict the failure of a system is gaining momentum but there are practical issues that challenge the mainstream implementation of canary device based prognostics. This paper provides a general methodology for implementation of the canary based prognostics. This paper presents an approach to tackle practical issues including determining the number of canary devices required and the confidence in the prediction for a particular number of canaries. A failure prediction scheme to estimate system failure based on the failure of the canary device in the field, is also presented in this paper.
Specific Kv1.3 blockade modulates key cholesterol-metabolism-associated molecules in human macrophages exposed to ox-LDL (2012)

Cholesterol-metabolism-associated molecules, including scavenger receptor class A (SR-A), lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), CD36, ACAT1, ABCA1, ABCG1, and scavenger receptor class B type I, can modulate cholesterol metabolism in the transformation from macrophages to foam cells. Voltage-gated potassium channel Kv1.3 has increasingly been demonstrated to play an important role in the modulation of macrophage function. Here, we investigate the role of Kv1.3 in modulating cholesterol-metabolism-associated molecules in human acute monocytic leukemia cell-derived macrophages (THP-1 macrophages) and human monocyte-derived macrophages exposed to oxidized LDL (ox-LDL). Human Kv1.3 and Kv1.5 channels (hKv1.3 and hKv1.5) are expressed in macrophages and form a heteromultimeric channel. The hKv1.3-E314 antibody that we had generated as a specific hKv1.3 blocker inhibited outward delayed rectifier potassium currents, whereas the hKv1.5-E313 antibody that we had generated as a specific hKv1.5 blocker failed. Accordingly, the hKv1.3-E314 antibody reduced percentage of cholesterol ester and enhanced apoA-I-mediated cholesterol efflux in THP-1 macrophages and human monocyte-derived macrophages exposed to ox-LDL. The hKv1.3-E314 antibody downregulated SR-A, LOX-1, and ACAT1 expression and upregulated ABCA1 expression in THP-1 macrophages and human monocyte-derived macrophages. Our results reveal that specific Kv1.3 blockade represents a novel strategy modulating cholesterol metabolism in macrophages, which benefits the treatment of atherosclerotic lesions.
Ultrathin Polyimide Films from Preformed Polymers (1997)

Multilayer films of preformed polyimide molecules have been obtained for the first time by the Langmuir−Blodgett technique. The pressure−area isotherm shows that the polyimide monolayers are strongly dependent on compression rate. The zero-pressure area per repeat unit is about 1.7 nm2 when the film is compressed at 100 cm2/min. This value is higher than that expected (1.2 nm2) for a closely packed structure. Multilayers have been investigated with X-ray reflectometry. The thickness of a bilayer film is about 4.05 nm, which is between the average bilayer thickness of a interdigitated multilayer film and that of a bilayer film containing closely packed backbones and fully extended alkyl side chains. The multilayer films do not display a distinctively periodic structure. When the films are annealed for a few hours at 180 °C, the structure relaxes somewhat and thickness decreases slightly.
Prevention of Cerebral Vasospasm by Calcitonin Gene-related Peptide Slow-release Tablet after Subarachnoid Hemorrhage in Monkeys (1996)

The CGRP tablet prevented cerebral vasospasm after SAH and may have significant potential for the treatment of patients with SAH.
Complete Genome Sequences of Six Copper-Resistant Xanthomonas citri pv. citri Strains Causing Asiatic Citrus Canker, Obtained Using Long-Read Technology (2017)

The gammaproteobacterium <i>Xanthomonas citri</i> pv<i>.</i> citri causes Asiatic citrus canker. Pathotype A strains have a broad host range, which includes most commercial citrus species, and they cause important economic losses worldwide. Control often relies on frequent copper sprays. We present here the complete genomes of six <i>X. citri</i> pv<i>. </i>citri copper-resistant strains.
Anti-angiogenic activity of resveratrol, a natural compound from medicinal plants (2004)

Resveratrol (3,4',5-trihydroxy-trans-stilbene), a naturally occurring phytoalexin found in grapes and wine, possesses cancer-preventive activity. Angiogenesis is a crucial step in the growth and metastasis of cancers. We have investigated the effect of resveratrol on angiogenesis in vitro and ex vivo, and found that resveratrol directly inhibited human umbilical vein endothelial cell growth and decreased the gelatinolytic activities of matrix metalloproteinase-2. Tube formation was inhibited by treatment with resveratrol after plating endothelial cells on Matrigel. Resveratrol treatment also inhibited endothelial cell attachment to basement membrane components fibronectin and laminin, and displays similar behavior on cell chemotaxis. In addition, resveratrol has been found to be an angiogenesis inhibitor in the rat aorta matrix culture model. Therefore, inhibition of angiogenesis associated with cancer may be a novel mechanism for the anticancer activity of resveratrol.
Carbon Monoxide Dehydrogenase from Gö1 (1996)

Carbon monoxide dehydrogenase (Cdh) has been anaerobically purified from Methanosarcina frisia Gö1. The enzyme is a Ni2+-, Fe2+-, and S2--containing alpha2beta2 heterotetramer of 214 kDa with a pI of 5.2 and subunits of 94 and 19 kDa. It has a Vmax of 0.3 mmol of CO min-1 mg-1 and Km values for CO and methyl viologen of approximately 0.9 mM and 0.12 mM, respectively. EPR spectroscopy on the reduced enzyme showed two overlapping signals: one indicative for 2 (4Fe-4S)+ clusters and a second signal that is atypical for standard Fe/S clusters. The latter was, together with high-spin EPR signals of the oxidized enzyme tentatively assigned to an Fe/S cluster of high nuclearity.
On the role of cortical glutamate inobsessive‐compulsive disorder and attention‐deficit hyperactivity disorder, two phenomenologically antithetical conditions (2000)

It appears that OCD is a hyperglutamatergic and ADHD a hypoglutamatergic condition, with prefrontal brain regions being especially affected.
In vivo construction of cDNA libraries for use in the yeast two‐hybrid system (1999)

We describe a simple and efficient one-step method to make cDNA libraries using homologous recombination in yeast. cDNA from any source, together with a linear vector, is used to transform yeast. Through homologous recombination and gap repair, the cDNA is unidirectionally incorporated into the yeast expression vector in vivo. The cDNA-encoded proteins can then be screened for potential protein–protein interactions with a bait already present in the yeast. This method allows rapid construction and screening of cDNA libraries, even from extremely small amounts of mRNA, and can replace the use of conventional cDNA libraries. Copyright © 1999 John Wiley & Sons, Ltd.
ChemInform Abstract: Selective Fluorinations by Reagents Containing the OF Group (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The Cancer Genome Atlas output and practice of gastric cancer (2015)

Any clinical professionals who devote themselves to prevention, diagnosis, therapy, and management of gastric cancer patients are now again facing another achievement by the consortium of The Cancer Genome Atlas (TCGA) (1). In the era of post human genome sequence and massive parallel sequencing technology, every week this kind of huge data draw a transient attention of our colleagues who are very busy with conventional routines. Information like this on the cutting edge of science is not usually related to the action plan next week at the clinic. In a field of lung cancer managements, however, we witnessed the latest fruits of these technologies such as series of discoveries of targetable fused-kinase protein drastically changed clinical practice (2)
Right ventricular function in transcatheter mitral and tricuspid valve edge-to-edge repair (2022)

Since transcatheter edge-to-edge repair (TEER) has become a valuable therapy in the treatment of both, mitral (MR) and tricuspid regurgitation (TR), the question of optimized patient selection has gained growing importance. After years of attributing rather little attention to the right ventricle (RV) and its function in the setting of valvular heart failure, this neglect has recently changed. The present review sought to summarize anatomy and function of the RV in a clinical context and aimed at presenting the current knowledge on how the RV influences outcomes after TEER for atrioventricular regurgitation. The anatomy of the RV is determined by its unique shape, which necessitates to use three-dimensional imaging methods for detailed and comprehensive characterization. Complex parameters such as RV to pulmonary artery coupling (RVPAc) have been developed to combine information of RV function and afterload which is primary determined by the pulmonary vasculature and LV filling pressure. Beyond that, TR, which is closely related to RV function also plays an important role in the setting of TEER. While mitral valve transcatheter edge-to-edge repair (M-TEER) leads to reduction of concomitant TR in some patients, the prognostic value of TR in the setting of M-TEER remains unclear. Overall, this review summarizes the current state of knowledge of the outstanding role of RV function and associated TR in the setting of TEER and outlines the unsolved questions associated with right-sided heart failure.
Mononuclear Mixed β‐Ketoester‐alkoxide Compound of Titanium as a Promising Precursor for Low‐Temperature MOCVD of TiO2 Thin Films (2003)

A monomeric titanium complex suitable for liquid‐injection MOCVD applications is synthesized and its molecular structure is determined by single‐crystal X‐ray diffraction. [Ti(O i Pr) 2 ‐(tbaoac) 2 ] (see Figure), (tbaoac) = tertiarybutylacetoacetonate), is a volatile alkoxide‐(beta)diketonate precursor that has a low melting point and very good solubility in common organic solvents.
Nucleotide sequence and expression of the gene encoding theEcoRII modification enzyme (1987)

The gene coding for the EcoRII modification enzyme has been cloned and the nucleotide sequence of 1933 base pairs containing the gene has been determined. The gene codes for a protein of 477 amino acids. Two transcriptional start sites have been mapped by S1 mapping. One deletion that removes 34 N-terminal amino acids was found to have partial enzyme activity. Comparison of the EcoRII methylase sequence with other cytosine methylases revealed several domains of partial homology among all cytosine methylases. Cloning the gene in multicopy pUC vectors increased the expression by 6-18 fold. A 40 fold overproduction of the EcoRII methylase was obtained by cloning the gene in the expression vector carrying the lambda PL promoter.