gebhart/patrepeval huggingface dataset:
Abstract 4982: N-myc downstream-regulated gene 1/Cap43 expression promotes cell differentiation of human osteosarcoma cells (2010)

Abstract N-myc downstream regulated gene 1 (NDRG1)/Cap43 is closely associated with cell differentiation, and its expression is induced by hypoxia and increasing intracellular calcium. Whether NDRG1/Cap43 expression in cancer cells is a predictive marker of good or poor prognosis in patients depends upon tumor types and differentiation status. In this study, we examined whether NDRG1/Cap43 expression was involved in differentiation of osteosarcoma cells, and used three osteosarcoma cell lines, MG63, U2OS, and SaOS2. Its expression in MG63 and U2OS was significantly enhanced by vitamin D3 that also induced production of osteocalcin, a differentiation marker of osteoblasts. Knockdown of NDRG1/Cap43 using siRNA also suppressed the production of osteocalcin and enhanced cell proliferation, accompanying by suppression of p21 expression. Furthermore, acquired invasiveness of osteosarcoma cells during invasion in Matrigel resulted in decreasing expression of NDRG1/Cap43. A possible role of NDRG1/Cap43 in cellular capacity for differentiation and invasion in osteosarcoma cells will be discussed. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4982.
The Advanced Interactive Debugging System (AIDS) (1979)

The Advanced Interactive Debugging System (AIDS) is described. It is a powerful high-level symbolic interactive debugging aid. AIDS is intended to be available in a program's environment without requiring debugging statements in the program's source code or inclusion of AIDS in the program's executable module.
A Randomized Controlled Trial of Oral Versus Intravenous Administration of a Nonnarcotic Analgesia Protocol Following Pediatric Craniosynostosis Corrections on Nausea and Vomiting Rates (2015)

The authors found a significant reduction in nausea and vomiting among children randomized to receive intravenous medications. In addition, the intravenous delivery of medications has the theoretical advantage of insuring an effective full dose delivery. Based on these findings, our standard process is to preferentially manage all children following craniosynostosis corrections with intravenous nonnarcotics.
Efficient, portable implementation of asynchronous multi-place programs (2009)

The X10 programming language is organized around the notion of places (an encapsulation of data and activities operating on the data), partitioned global address space (PGAS), and asynchronous computation and communication. This paper introduces an expressive subset of X10, Flat X10, designed to permit efficient execution across multiple single-threaded places with a simple runtime and without compromising on the productivity of X10. We present the design, implementation and evaluation of a compiler and runtime system for Flat X10. The Flat X10 compiler translates programs into C++ SPMD programs communicating using an active messaging infrastructure. It uses novel techniques to transform explicitly parallel programs into SPMD programs. The runtime system is based on IBM's LAPI (Low-level API) and is easily portable to other libraries such as GASNet and ARMCI. Our implementation realizes performance comparable to hand-written MPI programs for well-known HPC benchmarks such as Random Access, Stream, and FFT, on a Federation-based cluster of Power5 SMPs (with hundreds of processors) and the Blue Gene (with thousands of processors). Submissions based on the work presented in this paper were co-winners of the 2007 and 2008 HPC Challenge Type II Awards.
Rates and mechanism of biphenyl synthesis catalyzed by electrogenerated coordinatively unsaturated nickel complexes (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRates and mechanism of biphenyl synthesis catalyzed by electrogenerated coordinatively unsaturated nickel complexesChristian Amatore and Anny JutandCite this: Organometallics 1988, 7, 10, 2203–2214Publication Date (Print):October 1, 1988Publication History Published online1 May 2002Published inissue 1 October 1988https://pubs.acs.org/doi/10.1021/om00100a019https://doi.org/10.1021/om00100a019research-articleACS PublicationsRequest reuse permissionsArticle Views2355Altmetric-Citations153LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A fully integrated concurrent dual‐band CMOS low‐noise amplifier (2003)

Abstract This paper presents a fully integrated concurrent dual‐band CMOS low‐noise amplifier (LNA). The LNA is implemented in a standard 0.18‐μm 6M1P CMOS process and is designed from the system viewpoint to provide higher gain at the higher band, for the first time, to compensate the higher‐band signal's extra loss over the air transmission. The LNA drains 5.3 mA of current from a 1.8‐V supply voltage and achieves voltage gains of 16 and 22.5 dB, input return losses of 28 and 27 dB, and noise figures of 3.0 and 3.1 dB at 2.4 and 5.2 GHz, respectively. © 2003 Wiley Periodicals, Inc. Microwave Opt Technol Lett 39: 52–53, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.11124
Phylogenetic characterization of a new thermoacidophilic bacterium isolated from hot springs in Japan. (1997)

Three strains of thermophilic-acidophilic bacteria isolated previously from different hot springs in Japan were characterized by molecular genetic methods. The strategy taken involved PCR amplification, sequencing and restriction pattern analysis of 16S rDNA, 16S-23S rDNA spacer polymorphism analysis and genomic DNA-DNA hybridization. A phylogenetic analysis based on 16S rDNA sequences showed that the new thermoacidophilic isolates formed a genetically coherent group at the species level and fell into a major cluster together with members of the genera Alicyclobacillus and Sulfobacillus with A. acidocaldarius and A. acidoterrestris as their closest relatives. The levels of binary sequence similarity between the isolates and the two Alicyclobacillus species were 97.6 to 97.9%, values considered low enough to warrant placement of the isolates in a distinct species of the genus Alicyclobacillus. The 16S rDNA restriction pattern analysis, but not 16S-23S rDNA spacer polymorphism analysis, was useful for differentiating the isolates from the established Alicyclobacillus species. DNA-DNA hybridization assays demonstrated a distinct phylogenetic position of our isolates as a genospecies within the genus Alicyclobacillus. On the basis of these results, the thermoacidophilic isolates should be classified into a new species of Alicyclobacillus. The results of this study suggest that this new genospecies of Alicyclobacillus is widely distributed in hot springs in Japan.
Merging C–C σ-bond activation of cyclobutanones with CO2 fixation via Ni-catalysis (2022)

A carboxylative Ni-catalyzed tandem C-C σ-bond activation of cyclobutanones followed by CO<sub>2</sub>-electrophilic trapping is documented as a direct route to synthetically valuable 3-indanone-1-acetic acids. The protocol shows an adequate functional group tolerance and useful chemical outcomes (yield up to 76%) when AlCl<sub>3</sub> is adopted as an additive. Manipulations of the targeted cyclic scaffolds and a mechanistic proposal based on experimental evidence complete the investigation.
Beyond homogeneous dispersion: oriented conductive fillers for highκnanocomposites (2021)

Rational design of structures for regulating the thermal conductivities (<i>κ</i>) of materials is critical to many components and products employed in electrical, electronic, energy, construction, aerospace, and medical applications. As such, considerable efforts have been devoted to developing polymer composites with tailored conducting filler architectures and thermal conduits for highly improved <i>κ</i>. This paper is dedicated to overviewing recent advances in this area to offer perspectives for the next level of future development. The limitations of conventional particulate-filled composites and the issue of percolation are discussed. In view of different directions of heat dissipation in polymer composites for different end applications, various approaches for designing the micro- and macroscopic structures of thermally conductive networks in the polymer matrix are highlighted. Methodological approaches devised to significantly ameliorate thermal conduction are categorized with respect to the pathways of heat dissipation. Future prospects for the development of thermally conductive polymer composites with modulated thermal conduction pathways are highlighted.
Statistical Region-Based Active Contours with Exponential Family Observations (2006)

In this paper, we focus on statistical region-based active contour models where image features (e.g. intensity) are random variables whose distribution belongs to some parametric family (e.g. exponential) rather than confining ourselves to the special Gaussian case. Using shape derivation tools, our effort focuses on constructing a general expression for the derivative of the energy (with respect to a domain) and derive the corresponding evolution speed. A general result is stated within the framework of multi-parameter exponential family. More particularly, when using maximum likelihood estimators, the evolution speed has a closed-form expression that depends simply on the probability density function, while complicating additive terms appear when using other estimators, e.g. moments method. Experimental results on both synthesized and real images demonstrate the applicability of our approach
Transient integral boundary layer method to calculate the translesional pressure drop and the fractional flow reserve in myocardial bridges (2006)

The described boundary layer method can be used to simulate frictional forces and wall shear stresses in the entrance region of vessels. Earlier models are supplemented by the viscous effects in a quasi three-dimensional vessel geometry with a prescribed wall motion. The results indicate that the translesional pressure drop and the mean FFR compares favourably to clinical findings in the literature. We have further shown that the mean FFR under the assumption of Hagen-Poiseuille flow is overestimated in developing flow conditions.
Role of the sGC activator ataciguat sodium (HMR1766) in cardiovascular disease (2007)

Background Soluble guanylate cyclase (sGC), the key transducer of nitric oxide (NO) signaling, exists in two redox forms: the NO sensitive ferrous heme iron (Fe(II)) form and a NO insensitive oxidized form containing the ferric heme iron (Fe(III)). Ataciguat sodium (further named ataciguat) predominantly stimulates the oxidized form of sGC. To further define the therapeutic potential of ataciguat in cardiovascular disease, we investigated its effect in various in vivo models of: platelet aggregation, atherosclerosis and peripheral arterial occlusive disease.
Role of bone marrow transplantation in the treatment of hematologic malignancies and solid tumors: critical review of syngeneic, autologous, and allogeneic transplants. (1984)

Intensive chemoradiotherapy and bone marrow transplantation is effective for selected patients with acute or chronic leukemia, lymphoma, or solid tumors. This paper will summarize the results of treatment utilizing syngeneic transplants from identical twins, allogeneic transplants from HLA identical and nonidentical donors, and the use of the patient's own bone marrow cells in autologous bone marrow transplantation. The potential complications of marrow transplantation are described and the current results of bone marrow transplantation are compared with recent advances in alternative forms of treatment for these malignancies.
A hidden Markov model approach to the classification of acoustic transients (2002)

A system for the detection and classification of acoustic transients based on hidden Markov model (HMM) methods is described. The system was tested using two different sets of data. The results from these tests are summarized and compared to some other known algorithms and to the performance of human beings. The effect of observation noise on the training and classification process is also discussed, and results using different noise-correction techniques are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The effect of oat beta-glucan isolate on the rheology of dough from premium wheat flour and the quality of bakery products (2020)

420015, , , .
From autonomous assembly robots to service robots for factories (2002)

Besides the typical use of industrial robots in a manufacturing setting, new application areas for robots have been appearing during the past few years. In these areas, service robots perform general purpose activities without requiring repeated high speed movements or other requirements of industrial robot applications. For the development of service robots, the use and integration of research results obtained in the autonomous robot field is much more necessary than for the development of robots used in manufacturing. Both, high autonomy during service performance and simple system access, which also means flexible programming or user-friendly system control is desired over an easily operated man/machine interface. In this paper, properties of service robots are defined and some similarities and differences between service robots and fully autonomous robots are explained. The enhancement of an existing autonomous assembly robot, which is made to be a flexible service robot for industrial environments, is considered. The paper concludes with a running experiment, which shows how this robot prototype is used for different tasks in a manufacturing line.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Flavivirus Infections of Bats: Potential Role in Zika Virus Ecology (2016)

Understanding the vector and nonhuman vertebrate species contributing to Zika virus (ZIKAV) transmission is critical to understanding the ecology of this emerging arbovirus and its potential to establish in new geographic areas. This minireview summarizes what is known regarding the association of bats with flaviviruses (Flaviviridae: Flavivirus) with a particular emphasis on the potential role of bats in the sylvatic transmission of ZIKAV. Key research directions that remain to be addressed are also discussed.
Wet Air Oxidation of Some Ontario Sludges (Chemical) (1974)

Abstract A study was made of the wet air oxidation of eight Ontario sludges containing phosphates. Sludges were obtained from primary or secondary clarifiers in which lime, ferric chloride, or alum had been used to precipitate phosphates. A further set of sludges from the same plants which did not contain these chemical additives were used for comparison purposes. Sludges were oxidized at temperatures up to 550°F in a rocking autoclave; total carbon and total organic carbon values were measured in samples withdrawn during oxidation. Selected total phosphate and orthophosphate analyses were made on both chemical and non-chemical sludges. Oxidation of the sludges is readily obtained. Wet air oxidation reduced the stabilization of phosphates in chemical sludges, although this was not always the case in non-chemical sludges.
Synergy of oxygen and a piranha solution for eco-friendly production of highly conductive graphene dispersions (2014)

An ecofriendly approach for graphene fabrication is developed, where no toxic and metal containing compounds were used and no toxic byproducts were generated.
Ultrasensitive plasmonic biosensing (2018)

We demonstrate ultrasensitive detection of malaria aptamers performed with the help of graphene protected copper plasmonics. Using better morphology of copper surface as compared to gold, phase sensitive surface plasmon resonance schemes and graphene functionalization protocol for attaching end-tethering of DNA probes we were able to improve the detection level of malaria aptamers by an order of magnitude. This opens a way to associate a dormant bacterial population with chronic inflammatory diseases in blood samples using simple label-free optical detection.
Smart Optical Sensors for Industrial and Consumer Applications (2006)

ASTRI's smart sensors are based on our low cost plastic packaging platform. We integrate light sources and photodetectors as well as some electronic circuitry elements in a pre-molded plastic package. A precision distance sensor is developed where the diffuse reflection of a VCSEL beam is measured in a position sensitive photodetector element to accurately determine the object position. A micrometer resolution is achieved over several millimeters of working range. The same principle is applied to build a tilt sensor where the tilt of a small size micro chip can be measured with sub-degree accuracy. The application is in the semiconductor assembly industry. The key feature of the smart sensor component is its small size and its light weight, facilitating the mounting on fast moving parts. A different version of the distance sensor enables a touchless optical switch. The optical design with the VCSEL light source and the lens provides a precise switching level. Therefore the optical switch elements can be closely packed without optical crosstalk. The main application is for machines in public environments such as bank teller machines and elevators. The optical switch also enables hermitically sealed switches for outdoor applications
Endothelial Nitric Oxide Synthase Gene Polymorphism and Maternal Vascular Adaptation to Pregnancy (2001)

A common polymorphism of the endothelial NO synthase gene that predicts a Glu298Asp amino acid substitution in the mature protein has been associated with cardiovascular disorders in which NO bioactivity is impaired. However, the influence of this polymorphism on endothelial function is unknown. Healthy pregnancy is associated with enhanced endothelium-dependent, flow-mediated dilation (FMD) of the brachial artery, a response mediated by NO. In this study, we investigated the effect of the endothelial NO synthase Glu298Asp polymorphism on endothelium-dependent vasodilation in early pregnancy, making the hypothesis that any genotype-dependent differences in NO generation would be more marked during pregnancy, when the production of NO is upregulated. FMD of the brachial artery was recorded during the first trimester in 139 healthy women with normal singleton pregnancies genotyped for the Glu298Asp variant of endothelial NO synthase. Maternal FMD exhibited a codominant inverse relation with the number of Asp298 alleles (r=-0.21, P=0.01). Among homozygotes for endothelial NO synthase Asp298, FMD (7.99+/-1.46%) was significantly lower than that observed among individuals homozygous for endothelial NO synthase Glu298 (10.12+/-3.44) (P=0.002). In a backward stepwise multiple regression analysis, vessel size (P<0.0001) and Glu298Asp polymorphism (P=0.01) were significantly and independently correlated with FMD. Our findings indicate that the endothelial NO synthase Glu298Asp polymorphism is associated with differences in endothelium-dependent dilation at 12-week gestation and are the first to implicate genetic factors in the normal vascular adaptation to pregnancy. They also provide a potential mechanism linking the endothelial NO synthase polymorphism with the development of cardiovascular disorders and have implications for understanding the genetic basis of preeclampsia.
Plasma Concentrations of the Vasoactive Peptide Fragments Mid-Regional Pro-Adrenomedullin, C-Terminal Pro-Endothelin 1 and Copeptin in Hemodialysis Patients: Associated Factors and Prediction of Mortality (2014)

Vasopressin, endothelin and adrenomedullin are vasoactive peptides that regulate vascular tone and might play a role in hypertensive diseases. Recently, laboratory assays have been developed to measure stable fragments of vasopressin, endothelin and adrenomedullin. Little is known about their diagnostic and prognostic value in hemodialysis patients. In this study, we measured the plasma concentration of copeptin, mid-regional-pro-adrenomedullin (MR-pro-ADM) and C-terminal pro-endothelin 1 (CT-pro-ET1) in stable ambulatory hemodialysis patients (n = 239) and investigated their associations with clinical factors and mortality. In all patients enrolled, the plasma concentrations of copeptin, MR-pro-ADM and CT-pro-ET1 were largely elevated with a median concentration of 132 pmol/L (interquartile range [IQR] 78-192) for copeptin, 1.26 nmol/ L (IQR 1.02-1.80) for MR-pro-ADM and 149 pmol/L (IQR 121-181) for CT-pro-ET1. The plasma concentrations of all vasoactive peptide fragments correlated with time on dialysis and plasma b2-microglobulin concentration and were negatively correlated to residual diuresis. The plasma concentration of MR-pro-ADM was a strong predictor of all-cause (univariate hazard ratio for a 10-fold increase 9. 94 [3.14;32], p,0.0001) and cardiovascular mortality (hazard ratio 34.87 [5.58;217], p = 0.0001) within a 3.8-year follow-up. The associations remained stable in models adjusted for dialysis specific factors and were attenuated in a full model adjusted for all prognostic factors. Plasma copeptin concentration was weakly associated with cardiovascular mortality (only in univariate analysis) and CT-pro-ET1 was not associated with mortality at all. In conclusion, vasoactive peptide fragments are elevated in hemodialysis patients because of accumulation and, most likely, increased release. Increased concentrations of MR-pro-ADM are predictive of mortality.
Approximations for multiproduct contracts with stochastic demands and business volume discounts: single supplier case (1998)

In this paper we analyze contracts for multiple products when the supplier offers business volume discounts. The contract takes the form of price discounts for total minimum dollar volume commitments over the horizon with flexibility to adjust the total purchases upwards by a fixed percentage about this minimum commitment. The optimal policy could be complex since it involves the solution of a constrained multi-period multi-product dynamic program. We suggest approximations that give us an upper bound. To develop this upper bound, we present the optimal policy for a similar contract for a single product problem. We then develop a lower bound for the multiproduct problem and show, numerically, that the gap is small. Given the approximations standard single period resource allocation algorithms can be used to solve the problem. The resulting solution methodology is fast and permits evaluation of various what-if scenarios.