gebhart/patrepeval huggingface dataset:
A Globalized Model for Mapping Wearable Seismocardiogram Signals to Whole-Body Ballistocardiogram Signals Based on Deep Learning (2019)

The ballistocardiography (BCG) signal is a measurement of the vibrations of the center of mass of the body due to the cardiac cycle and can be used for noninvasive hemodynamic monitoring. The seismocardiography (SCG) signals measure the local vibrations of the chest wall due to the cardiac cycle. While BCG is a more well-known modality, it requires the use of a modified bathroom scale or a force plate and cannot be measured in a wearable setting, whereas SCG signals can be measured using wearable accelerometers placed on the sternum. In this paper, we explore the idea of finding a mapping between zero mean and unit l<sub>2</sub>-norm SCG and BCG signal segments such that, the BCG signal can be acquired using wearable accelerometers (without retaining amplitude information). We use neural networks to find such a mapping and make use of the recently introduced UNet architecture. We trained our models on 26 healthy subjects and tested them on ten subjects. Our results show that we can estimate the aforementioned segments of the BCG signal with a median Pearson correlation coefficient of 0.71 and a median absolute deviation (MAD) of 0.17. Furthermore, our model can estimate the R-I, R-J and R-K timing intervals with median absolute errors (and MAD) of 10.00 (8.90), 6.00 (5.93), and 8.00 (5.93), respectively. We show that using all three axis of the SCG accelerometer produces the best results, whereas the head-to-foot SCG signal produces the best results when a single SCG axis is used.
Virus-assisted loading of polymer nanocontainer (2002)

We present a DNA-containing polymeric nanocontainer using the self-assembled superstructure of amphiphilic block copolymers in aqueous solutions. To demonstrate that DNA translocation is possible across a completely synthetic block copolymer membrane, we have used a phage transfection strategy as a DNA-transfer model system. For this purpose the bacterial channel forming protein LamB was reconstituted in ABA-triblock copolymer vesicles. The outer membrane protein LamB is a specific transporter for maltodextrins but also serves as a receptor for lambda phage to trigger the ejection of lambda phage DNA. We demonstrate that the functionality of the LamB protein is fully preserved despite the artificial surrounding. This leads to a type of polymeric vehicle for DNA that could be useful for gene therapy.
Comparative Transcriptome Analyses of Metastatic and Non-Metastatic Colorectal Cancer Cells Delineate Differential Mechanisms of CHOP Upregulation in Response to ONC201 Treatment (2020)

The imipramine ONC201 exerts a novel anti-proliferative activity over a wide spectrum of cancer cell types. ONC201 activates integrated stress response pathway that is associated with induction of Damage Inducible Transcript 3 (DDIT3, also known as C/EBP homologous protein or CHOP). We questioned whether the ONC201/CHOP crosstalk is regulated by diverse signaling pathways in non-metastatic versus metastatic cancer cell lines. Therefore, the Dukes' type B colorectal adenocarcinoma non-metastatic (SW480) and metastatic (LS-174T) cell lines were treated with ONC201. Cell proliferation and apoptosis were evaluated by MTT assay, flow cytometry analysis, gene expression was assessed by Affymetrix microarray, and key regulatory proteins were validated by Western blot assays. Unlike LS-174T cells, SW480 cells were resistant to ONC201 treatment. Gene ontology pathway enrichment analysis of differentially expressed genes revealed substantial differences between LS-174T and SW480 responsiveness to ONC201 treatment. In both cell lines, CHOP expression was upregulated in response to ONC201 treatment, however, its upstream regulatory mechanisms were not identical. Although, PERK, ATF6 and IRE1 ER-stress pathways were found to upregulated CHOP in both cell types, the BAK/BAX pathway was a notable regulator of CHOP in the metastatic LS-174T cells alone. In addition, CHOP RNA splicing profiles were varied between the two cell lines, which was further modified in response to ONC201 treatments. In conclusion, we delineated the signaling mechanisms regulating the expression of CHOP in non-metastatic versus metastatic colorectal cells in response to ONC201 treatment. The observed differences were related to cellular plasticity and metabolic reprogramming.
Investigating the phytotoxic potential of Carlina acaulis essential oil against the weed Bidens pilosa through a physiological and metabolomic approach (2023)

Essential oils (EOs) are widely studied as possible candidates for new eco-friendly herbicides for weed management due to their phytotoxicity. In this study we tested the phytotoxic potential of the EO obtained from the roots of Carlina acaulis L. (Apiaceae) against the weed Bidens pilosa L. This EO, containing 98% of the polyacetylene carlina oxide, showed strong phytotoxic effects on the plant metabolism, such as leaf necrosis, reduction of relative water content and total leaf area, and an increase in the dry weight/fresh weight ratio, suggesting a water status alteration. The EO also damaged the photosynthetic machinery, as evidenced by the significant reduction of the effective quantum yield of photosystem II (ΦII) and the maximum quantum yield of photosystem II (Fv/Fm). In addition, the non-photochemical quenching (ΦNPQ) significantly increased after spraying with C. acaulis EO. Damage to photosystem II was further demonstrated through the reduction of manganese and calcium concentrations, possibly due to an alteration in the correct functionality of the Mn4Ca cluster of the PSII. Metabolomics analysis revealed an accumulation of branched-chain amino acids, such as isoleucine and valine, which is commonly related to osmotic alterations under drought stress situations and a general reduction in sugar content (fructose, glucose, mannose, among others), suggesting reduction of the photosynthetic efficiency too. Overall, these findings suggest C. acaulis EO as a promising natural product with phytotoxic potential against weeds that deserves further investigation.
Band Bending and Work Function (2015)

Important parameters of the analysis of electron field emission from semiconductors are the band bending and work function are considered. Surface space-charge region, quantization of electron energy spectra at semiconductor surface, image charge potential are analyzed in details. The work function as the most important parameter at electron field emission and its changing at cathode coating with film, under electric field, temperature and surface adatoms are under consideration.
Inhibition of allergen‐induced dermal eosinophilia by an oxoeicosanoid receptor antagonist in non‐human primates (2019)

5-Oxo-ETE may play an important role in allergen-induced eosinophilia. Blocking its effects with S-Y048 may provide a novel therapeutic approach for eosinophilic diseases.
Dialog: The Future of Acidizing? (1998)

Dialog - Discussion/Reply. No abstract available.
Effects of dietary fat, NaCl, and fructose on renal sodium and water transporter abundances and systemic blood pressure (2004)

Dietary fructose, NaCl, and/or saturated fat have been correlated with mean arterial pressure (MAP) rises in sensitive strains of rats. Dysregulation of sodium and/or water reabsorption by the kidney may contribute. Using radiotelemetry and parallel semiquantitative immunoblotting, we examined the effects of various diets on MAP and the regulation of abundance of the major renal sodium and water transport proteins in male Sprague-Dawley rats. In study 1, rats ( approximately 275 g) were fed one of four diets for 4 wk (n = 6/group): 1) control, 2) 65% fructose, 3) control + added NaCl (2.59%), or 4) fructose + NaCl. In study 2, 5% butter (fat) was added to the above four diets. Both fat and NaCl, but not fructose, caused modest rises in MAP (5-10 mmHg) and increased the day-to-night ratio in diastolic blood pressure. NaCl or fructose increased kidney size. Creatinine clearance was increased by salt or fat, and fractional excretion of sodium was decreased by fat. In study 1, high NaCl markedly reduced plasma renin and aldosterone and its regulated proteins in whole kidney, i.e., the thiazide-sensitive Na-Cl cotransporter and the alpha- and gamma (70-kDa band)-subunits of the epithelial sodium channel. These effects were blunted by fat. Fructose increased the abundance of the sodium phosphate cotransporter, whereas it decreased the bumetanide-sensitive Na-K-2Cl cotransporter and aquaporin-2. Overall, doubling of dietary fat appeared to impair dietary sodium adaptation, i.e., blunt the downregulation of aldosterone-mediated effects, thus allowing blood pressure to rise at an accelerated rate.
Integrated digital control and filtering for an electrodynamically compensated weighing cell (1989)

An integrated digital control and filtering system (IDCFS) has been designed for a high-resolution electrodynamically compensated weighing cell. This system provides faster response time and higher robustness with respect to disturbances than current analog equipment. The basic concept of the IDCFS and major problems of its hardware and software design are discussed. In addition, an intelligent multifilter scheme is presented for high-precision measurement applications. Experimental results obtained for a prototype weighing cell equipped with an IDCFS are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Dynamic models of the glottal pulse (1995)

info:eu-repo/semantics/published
Abstract 14017: Prognostic Impact of Peak Heart Rate During Exercise in Atrial Fibrillation (2016)

Background and Aim: Heart rate (HR) during exercise is known to be associated with cardiovascular morbidity/mortality in sinus rhythm (SR). However, the relationship between HR profile during exercise and cardiovascular prognosis remain unknown well in patients with atrial fibrillation (AF). We previously reported that peak VO2 but not resting HR is an independent predictor for future heart failure (HF) events in patients with AF. The aim of this study was to investigate the relationships between HR profile during exercise and future heart failure (HF) events in patients with AF and those with SR simultaneously. Methods: We used the cohort from the single-hospital database between 2004 and 2013 (N=22,230). Of the total, 2,231 patients (AF; N=321, SR; N=1910) who underwent symptom-limited cardiopulmonary exercise testing were analyzed. HF events were defined as either hospitalization for HF or death from HF. They were categorized according to the quartiles of peak HR in each rhythm. Results: Significant positive relationships between peak HR quartiles and peak VO2 were observed in both groups (AF: p for trend &lt;0.001, SR: p for trend &lt;0.001). Peak HR quartiles were also apparently negatively associated with the incidence of HF events in both groups (Figure). In univariate analysis for HF events, peak HR was significantly related to HF events in both rhythms. Multivariate analysis showed that peak HR was a statistically significant predictor for HF events in the AF group even after adjusted for age, use of HR lowering drugs, left ventricular ejection fraction, organic heart disease and eGFR. However, in the SR group, predictive power of peak HR was weakened after the same adjustment. Conclusion: It was suggested that peak HR is an independently strong predictor for future HF events in patients with AF.
<title>Scalable multiple description coding of video using motion-compensated temporal filtering and embedded multiple description scalar quantization</title> (2004)

Real time delivery of video over best-effort and error-prone networks requires compression systems that dynamically adapt the rate to the available channel capacity and exhibit robustness to loss of some data as retransmission is often impractical. Error resiliency, however, significantly lowers the coding performance when rigid design is performed based on a worst-case scenario. This paper presents a scalable video coding scheme that couples the compression efficiency of the open-loop architecture with the robustness of multiple description source coding. The use of embedded multiple description quantization and a novel channel-aware rate-allocation allows for shaping on-the fly the output bit-rate and the degree of resiliency without resorting to channel coding. As a result, robustness to data losses is traded for better visual quality when transmission occurs over reliable channels, while error resilience is introduced when noisy links are involved. The advantage of our proposal is demonstrated in the context of packet-lossy networks comparing the performance of similar instantiations of the video codec employing non-scalable redundancy.
Mechanism of the malabaricone C-induced toxicity to the MCF-7 cell line (2014)

In this study, we studied the mechanism of the cytotoxicity of malabaricone C (mal C) against human breast cancer MCF-7 cell line. Mal C dose-dependently increased the sub G1 cell population, associated with cytoplasmic oligonucleosome formation and chromatin condensation. The mal C-induced apoptosis led to mitochondrial damage as revealed by fluorescence microscopy and flow cytometry of the JC-1-stained cells as well as from the release of mitochondrion-specific nuclease proteins AIF and endo G. Mal C also released intracellular Ca(2+) from the MCF-7 cells, but the Ca(2+)-modulators BAPTA-AM and Ru360 only partially abrogated the apoptosis. The calpain activation by mal C did not have any effect on its cytotoxicity. On the other hand, after mal C treatment significant lysosomal membrane permeabilization (LMP), along with release of cathepsin B, as well as Bid-cleavage and its translocation to mitochondria were observed much earlier than the mitochondrial damage. This suggested that cytotoxicity of mal C against human MCF-7 human breast cancer cell line may proceed through LMP as the initial event that triggered a caspase-independent, but cathepsin B and t-Bid-dependent intrinsic mitochondrial apoptotic pathway. A significant accumulation of cells in the S or G2-M phases along with upregulation of the cyclins E and A due to mal C exposure promises it to be a potential anti-cancer agent.
Data management in the intelligent network (2005)

The Intelligent Network offers a flexible architecture based on a generic set of components upon which new services can be built. The distribution of functions over IN nodes (SSP, SCP and SMS) leads to concentrating call processing logic along with service-related data into the SCP and/or SMS. As such, a set of tools is necessary within IN nodes to define and manipulate data and to ensure data consistency. This paper recalls the facilities expected by IN data users, then presents the different data management tools implemented in Alcatel's Intelligent Network. How such tools are used to enable an IN service is illustrated through the example of Free phone.
Synthesis of conjugated covalent organic frameworks/graphene composite for supercapacitor electrodes (2015)

A novel imine-linked covalent organic framework on graphene composite with excellent electrochemical properties was conveniently synthesized in one step.
Experimental Validation of a Tissue-Joining Implant Providing Flexible Adaptation to the Thickness of the Stomach Wall (2010)

Endoscopy is gradually replacing open surgery in the gastrointestinal tract. Therefore, novel medical devices and instrumentation are required, such as flexible miniaturized mechanisms for tissue joining and manipulation. In this paper, an absorbable implant for the purpose of long-term tissue fixation is presented. An experimental validation of the implant design and functionality is introduced. The implant achieves tissue penetration and provides flexible adaptation according to the thickness of two stomach walls. This mechanism is easy as it is based on push-pull principle using unidirectional forces. The shape optimization of each implant part occurs by varying design-influencing factors. The load transmission on postmortem porcine tissue was measured in the frame of the experimental setup. The feasibility of the implant was tested, and the forces needed for the intended application quantified. The implant successfully achieves tissue penetration, load transmission, adjustment, and fixation. It is a new alternative to conventional tissue-joining mechanisms.
Abnormal Cell Envelope Ultrastructure of a Saccharomyces Mutant with Invertase Formation Resistant to Hexoses (1973)

The most obvious morphological characteristic of Saccharomyces mutant FH4C cells is the tendency to form clumps (production of invertase and alpha-glucosidase by this mutant is highly resistant to repression by hexoses). This peculiar feature arises from the abnormal cell envelope ultrastructure of the mutant. Clumps are formed as a result of the failure of the cell wall of the bud to separate from that of the mother cell. The cell wall also shows irregular thickening. There are many cells with a doughnut shape and with small budlike protrusions. Abnormal septation and wall invagination into vacuoles give rise to cells of differing sizes and irregular profiles. Many vesicles, tubules, and coiled membranous bodies originate from invaginations of the plasmalemma. These structures are frequently observed in the cell wall or the periplasmic space. The cells of mutant FH4C growing in 0.2 M glucose, unlike parent strain 303-67, contain many mitochondria. Large numbers of glycogen deposits are also found in many cells of FH4C.
Organic Reactions with Boron Fluoride.1 XIII. The Alkylation of Benzene with Alcohols (1937)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOrganic Reactions with Boron Fluoride.1 XIII. The Alkylation of Benzene with AlcoholsJames F. McKenna and Frank J. SowaCite this: J. Am. Chem. Soc. 1937, 59, 3, 470–471Publication Date (Print):March 1, 1937Publication History Published online1 May 2002Published inissue 1 March 1937https://pubs.acs.org/doi/10.1021/ja01282a012https://doi.org/10.1021/ja01282a012research-articleACS PublicationsRequest reuse permissionsArticle Views188Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Micropatterning Assay for Measuring Cell Chirality (2022)

Chirality is an intrinsic cellular property, which depicts the asymmetry in terms of polarization along the left-right axis of the cell. As this unique property attracts increasing attention due to its important roles in both development and disease, a standardized quantification method for characterizing cell chirality would advance research and potential applications. In this protocol, we describe a multicellular chirality characterization assay that utilizes micropatterned arrays of cells. Cellular micropatterns are fabricated on titanium/gold-coated glass slides via microcontact printing. After seeding on the geometrically defined (e.g., ring-shaped), protein-coated islands, cells directionally migrate and form a biased alignment toward either the clockwise or the counterclockwise direction, which can be automatically analyzed and quantified by a custom-written MATLAB program. Here we describe in detail the fabrication of micropatterned substrates, cell seeding, image collection, and data analysis and show representative results obtained using the NIH/3T3 cells. This protocol has previously been validated in multiple published studies and is an efficient and reliable tool for studying cell chirality in vitro.
EPR spectra of eight-coordinated complexes of the early transition metals with sulfur and selenium donor ligands. 1. Vanadium(IV) and niobium(IV) dithiocarboxylates (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEPR spectra of eight-coordinated complexes of the early transition metals with sulfur and selenium donor ligands. 1. Vanadium(IV) and niobium(IV) dithiocarboxylatesD. Attanasio, C. Bellitto, and A. FlaminiCite this: Inorg. Chem. 1980, 19, 11, 3419–3424Publication Date (Print):November 1, 1980Publication History Published online1 May 2002Published inissue 1 November 1980https://pubs.acs.org/doi/10.1021/ic50213a041https://doi.org/10.1021/ic50213a041research-articleACS PublicationsRequest reuse permissionsArticle Views110Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Dual-Frequency Piezoelectric Transducers for Contrast Enhanced Ultrasound Imaging (2014)

For many years, ultrasound has provided clinicians with an affordable and effective imaging tool for applications ranging from cardiology to obstetrics. Development of microbubble contrast agents over the past several decades has enabled ultrasound to distinguish between blood flow and surrounding tissue. Current clinical practices using microbubble contrast agents rely heavily on user training to evaluate degree of localized perfusion. Advances in separating the signals produced from contrast agents versus surrounding tissue backscatter provide unique opportunities for specialized sensors designed to image microbubbles with higher signal to noise and resolution than previously possible. In this review article, we describe the background principles and recent developments of ultrasound transducer technology for receiving signals produced by contrast agents while rejecting signals arising from soft tissue. This approach relies on transmitting at a low-frequency and receiving microbubble harmonic signals at frequencies many times higher than the transmitted frequency. Design and fabrication of dual-frequency transducers and the extension of recent developments in transducer technology for dual-frequency harmonic imaging are discussed.