gebhart/patrepeval huggingface dataset:
Correction to “Catalytically Relevant Intermediates in the Ni-Catalyzed C(sp2)–H and C(sp3)–H Functionalization of Aminoquinoline Substrates” (2021)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to "Catalytically Relevant Intermediates in the Ni-Catalyzed C(sp2)–H and C(sp3)–H Functionalization of Aminoquinoline Substrates"Pronay RoyPronay RoyMore by Pronay Royhttps://orcid.org/0000-0002-5649-8747, James R. BourJames R. BourMore by James R. Bourhttps://orcid.org/0000-0002-0372-7323, Jeff W. KampfJeff W. KampfMore by Jeff W. Kampfhttps://orcid.org/0000-0003-1314-8541, and Melanie S. Sanford*Melanie S. SanfordMore by Melanie S. Sanfordhttps://orcid.org/0000-0001-9342-9436Cite this: J. Am. Chem. Soc. 2021, 143, 34, 14021Publication Date (Web):August 18, 2021Publication History Published online18 August 2021Published inissue 1 September 2021https://pubs.acs.org/doi/10.1021/jacs.1c07700https://doi.org/10.1021/jacs.1c07700correctionACS PublicationsCopyright © 2021 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views3475Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (515 KB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Response to Comment on " HST2 Mediates SIR2 -Independent Life-Span Extension by Calorie Restriction" (2006)

Our two labs and others have shown that SIR2 controls the life span of diverse species, including Saccharomyces cerevisiae and Drosophila melanogaster, and that deleting SIR2 blocks life-span extension by calorie restriction. The methods of Kaeberlein et al . allow yeast to bypass the requirement for SIR2 and its homologs, which brings into question their suitability for modeling the physiology of more complex organisms.
Scientific and Engineering Challenges Impacting the Design of Advanced Internal Combustion Engines. (2013)

Abstract not provided.
Study of warping torsion of thin-walled beams with open cross-section using macro-elements (1999)

Thin-walled beams with open cross-section under torsion or complex load are studied based on the hypotheses of the classical theory (Vlasov). Different from previous techniques presented in the literature, the concept of a strip-plate is introduced. This concept is used to accurately model the effect of bending induced by torsion and to define an alternate finite element called macro-element. The macro-elements are shown to model more accurately the thin-walled beams under warping torsion or complex load therefore giving better results than the classical theory. Copyright © 1999 John Wiley & Sons, Ltd.
Neuropharmacology of paroxetine. (2003)

Paroxetine is a potent and selective serotonin reuptake inhibitor (SSRI) with some neuropharmacologic properties unique among this class of compounds. The findings of early in vitro studies demonstrated the potency of paroxetine at inhibiting 5-HT uptake in rat synaptosomes. Paroxetine also has been shown to be a potent and selective inhibitor of the human serotonin transporter (SERT) and has recently been demonstrated to have moderate affinity for the norepinephrine transporter (NET). Because of the affinity and in vitro selectivity of this SSRI, tritiated paroxetine is now widely used as a marker for SERT in laboratory settings, and its use has advanced our understanding of neurotransmitter function in the brain and periphery. The in vivo pharmacologic properties of paroxetine are well characterized, especially following acute administration. However, the pharmacologic effects of chronically administered paroxetine remain an active area of study. Paroxetine administration in laboratory animals has been shown to be associated with decreased SERT density and function, maintenance of normal firing rates and release of 5-HT, and increased activation of postsynaptic 5-HT receptors. Using a novel ex vivo assay, we have demonstrated that paroxetine exhibits dose-related inhibition of the NET in patients treated for depression. At usual clinical doses (ie, 20 mg/d), paroxetine is a potent and selective inhibitor of the SERT; however, at higher doses (ie, 40 mg/d), paroxetine can exhibit marked NET inhibition. The application of these findings of in vivo NET inhibition by paroxetine in the treatment of mood and anxiety disorders will be informed by further clinical studies.
Increased Nitric Oxide in Exhaled Gas as an Early Marker of Lung Inflammation in a Model of Sepsis (1995)

Nitric Oxide (NO) has been implicated in the pathologic vasodilation of sepsis. Because NO can be measured in the exhaled gas of animals and humans, we hypothesized that increases in exhaled NO would occur in a septic model. Using a blinded design, 10 male Sprague-Dawley rats (300 to 400 g) were anesthetized, paralyzed, tracheotomized, and randomized (5/group) to receive an intravenous injection of either lipopolysaccharide (LPS) (Salmonella typhosa, 20 mg/kg) or placebo (equal volume of saline). Thereafter, exhaled gas was collected and measurements of NO concentration were made using chemiluminescence every 20 min for 300 min during ventilation (RR 40 breaths/min, VT 3 ml; PEEP 0, FIO2 0.21). Another group of 10 animals (5 LPS; 5 control) were treated in the same fashion and then killed at 240 min and an arterial blood sample obtained for blood gas and TNF alpha determinations. Pressure volume (PV) curves were constructed and lungs removed, preserved, and submitted for histologic evaluation. LPS-treated rats had lower mean arterial pressures than the control group, p < 0.0001. No significant differences in static lung compliance and PV curves were found in the two groups. TNF alpha levels were greater in the LPS group (1.40 +/- 0.24 ng/ml) versus control group (0.09 +/- 0.04 ng/ml), p < 0.001. By contrast to the control group, exhaled NO concentration rose in all LPS-treated rats at approximately 100 min and at about 160 min reached a plateau that was 6 times greater than control levels (p < 0.0001). There was greater interstitial, airspace, and total lung injury in the LPS group (p = 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
Supplementary Figure 7 from MicroRNA-494 Downregulates KIT and Inhibits Gastrointestinal Stromal Tumor Cell Proliferation (2023)

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A New Formulation of the Filter-Error Method for Aerodynamic Parameter Estimation in Turbulence (2015)

A new formulation of the filter-error method for estimating aerodynamic parameters in nonlinear aircraft dynamic models during turbulence was developed and demonstrated. The approach uses an estimate of the measurement noise covariance to identify the model parameters, their uncertainties, and the process noise covariance, in a relaxation method analogous to the output-error method. Prior information on the model parameters and uncertainties can be supplied, and a post-estimation correction to the uncertainty was included to account for colored residuals not considered in the theory. No tuning parameters, needing adjustment by the analyst, are used in the estimation. The method was demonstrated in simulation using the NASA Generic Transport Model, then applied to the subscale T-2 jet-engine transport aircraft flight. Modeling results in different levels of turbulence were compared with results from time-domain output error and frequency- domain equation error methods to demonstrate the effectiveness of the approach.
Design and Performance of the OpenBSD Stateful Packet Filter (pf) (2002)

With more and more hosts being connected to the Internet, the importance of securing connected networks has increased, too. One mechanism to provide enhanced security for a network is to filter out potentially malicious network packets. Firewalls are designed to provide “policy-based ” network filtering. A firewall may consist of several components. Its key component is usually a packet filter. The packet filter may be stateful to reach more informed decisions. The state allows the packet filter to keep track of established connections so that arriving packets could be associated with them. On the other hand, a stateless packet filter bases its decisions solely on individual packets. With release 3.0, OpenBSD includes a new Stateful Packet Filter (pf) in the base install. pf implements traditional packet filtering with some additional novel algorithms. This paper describes the design and implementation of pf and compares its scalability and performance with existing packet filter implementations. While an acceptable Open Source license was a prerequisite for any replacement, we used this opportunity to develop a new packet filter that employed optimized data structures and algorithms to achieve good performance for stateful filtering and address translation. The resulting code base is small and thus facilitates future extensions. The remainder of this paper is organized as follows. Section 2 outlines the design of the packet filter. In Section 3 we compare pf’s performance with other packet filters and discuss the results. Section 4 presents future work. Finally, we conclude in Section
An e-Map Navigation System with Visualized Landmark Information (2008)

Abstract—In this paper, a new e-Map navigation system is designed to provide users with regional navigation services. It provided users keyword search, multiple classification search, and region search, so that users ’ need for diversified searches can be satisfied. Besides, this system applies chromatology to visualize search results, using colors to present landmarks and different degrees of chroma to describe landmark information. It is expected that through improvement of the system design and the information retrieval interface, user’s search cost can be reduced and better navigation services can be provided in a more efficient manner. Index Terms—e-map, landmarks, navigation, visualization. I.
Reliable Estimation of Permeability from the 4D Strain Distribution in Poroelastic Tissues (2012)

The response of a poroelastic materials to a sustained applied unidirectional deformation is a volumetric strain propagating inside the tissue with a speed that is characteristic of the capacity of the fluid to diffuse through the elastic porous structure and the size of the sample. In the current work we investigated the role of the indenter size to measure a time of relaxation of the volumetric strain which relates only on the materials porous properties, without any influence of the size. The simulation showed that an indenter as big as 25% of the sample size can be an indenter small enough to provide reliable quantitative estimation. Experimental result, even if promising, do not permit to conclude on a definitive indenter size to obtain a similar result.
Ultrafast pipelined adders using RTTs (1991)

Ultrafast adders that perform 32 bit additions in less than 1 ns using resonant tunnelling transistors (RTTs) are proposed. Simulation results showing their subnanosecond performance are presented. The adders are shown to be better than others in terms of both area and speed. These results are obtained using true bistable logic which makes use of the bistability of circuits using the negative differential resistance (NDR) characteristic of the RTTs.
Efficient synthesis and characterisation of the amyloid beta peptide, Aβ1–42, using a double linker system (2018)

The amyloidogenic Aβ42 peptide was efficiently prepared using a double linker system, markedly improving solubility and chromatographic peak resolution, thus enabling full characterisation using standard techniques. The tag was readily cleaved with sodium hydroxide and removed by aqueous extraction, affording Aβ42 in high purity and yield for biophysical characterisation studies.
Thực trạng tuân thủ điều trị của bệnh nhân đái tháo đường điều trị ngoại trú tại bệnh viện đa khoa Thiệu hóa (2020)

Tổng quan: Tuân thủ điều trị (chế độ ăn, lối sống và dùng thuốc) là một trong các yếu tố quan trọng để đạt được hiệu quả trong điều trị đái tháo đường. Mục tiêu:Mô tả thực trạng tuân thủ điều trị của bệnh nhân đái tháo đường điều trị ngoại trú tại bệnh viện đa khoa Thiệu Hóa và xác định một số nguyên nhân hạn chế việc tuân thủ điều trị của đối tượng trên. Đối tượng và phương pháp nghiên cứu: Mô tả cắt ngang trên 200 bệnh nhân đái tháo đường đến khám và điều trị tại bệnh viện đa khoa Thiệu Hóa. Đối tượng nghiên cứu được phỏng vấn theo mẫu bệnh án thống nhất: đánh giá tuân thủ điều trị chế độ ăn, hoạt động thể lực, dùng thuốc và khám định kỳ. Kết quả: Trong số 200 bệnh nhân nghiên cứu, tỉ lệ bệnh nhân ≥ 60 tuổi chiếm 52,5%; tỉ lệ nữ giới chiếm 55,5%. Tỉ lệ bệnh nhân tuân thủ thường xuyên chế độ ăn, luyện tập và khám định kỳ lần lượt là 31,5%; 46,0% và 94,0%. Tỉ lệ bệnh nhân không tuân thủ chế độ ăn, luyện tập và khám định kỳ lần lượt là 25%, 25% và 6%. Tỷ lệ bệnh nhân quên uống thuốc là 27,7%. Tỉ lệ bệnh nhân chưa được tư vấn chế độ ăn và luyện tập lần lượt là 34% và 40,7%. Kết luận: Tỷ lệ tuân thủ điều trị chế độ ăn, hoạt động thể lực, dùng thuốc của bệnh nhân đái tháo đường khám ngoại trú tại bệnh viện đa khoa Thiệu Hóa còn thấp. Do đó, cần có các biện pháp tư vấn trực tiếp, giáo dục sức khỏe cho bệnh nhân.
Caustic Failure of Thermal Insulated Tubing in Steam Flooding (2009)

The coupling of the pre-stressed thermal insulated tubing string broke down inside the steam flooding welts, after the tubing were used in high temperature and high pressure steam for about two years. With further check, it was found that most of the weld joints between the inner and outer tubing also cracked. The failure analysis for the accidents has been carried out by the analysis of chemical composition for the steels, microstructure observation, mechanical property tests, and the investigation of the service environment etc.. The results show that the early damage of the pre-stressed thermal insulated tubing string is mainly induced by the caustic stress corrosion, which can be strengthened by an unstable microstructure of the coupling serviced at high temperature for a long time. Moreover, the high pre-stress design on the thermal insulated pipe for the cyclic steam injection may be not suitable to the situation of steam flooding, which would result in the weld joint cracking.
Synthesis, Physicochemical and Anticonvulsant Properties of N‐Benzyl and N‐Aminophenyl Derivatives of 2‐Azaspiro[4.4]nonane and [4.5]Decane‐1,3‐dione. Part 1. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Oriented Immobilization of Antibodies for Immunosensing (1998)

The covalent coupling of antibody fragments to linkers embedded in a monolayer matrix of phosphatidylcholine and cholesterol was examined at the air−water interface by the means of a quartz crystal microbalance, QCM. Two linkers that bind the free thiols of the Fab‘ fragment were investigated. The nonspecific binding of bovine serum albumin and the specific binding of antigen were also monitored with the QCM. Standardized radioimmunoassay was used to confirm the immunoreaction and determine binding parameters. The monolayer formation of the linker lipids in the ternary system of phosphatidylcholine and cholesterol was, moreover, demonstrated by film balance studies. The results demonstrate that the covalent coupling of Fab‘ fragments to linking groups embedded in a phospholipid monolayer matrix is a promising approach to achieve a defined immobilization of antibodies at the sensor surface with high antigen binding effeciency.
Fault detection in engines through higher order spectral analysis of acoustic signatures (1999)

This paper describes new engine fault detection methods that involve a higher order spectral analysis method known as the parametric spectral coherence (PSC). Measurements of radiated acoustic and vibrational signatures were conducted on a one-cylinder engine with a continuously worsening loss of cylinder compression. Compared to vibrational signatures, the radiated acoustic signatures provided the most dramatic indication of a loss of cylinder compression when PSC analysis was performed. It is demonstrated that the fault can be detected by simply monitoring the average spectral coherence or the peak spectral coherence of the acoustic signature, whereas the more traditional power spectral methods fail to detect the fault.
Antifungal activity of the volatiles of Agathosma betulina and Coleonema album commercial essential oil and their effect on the morphology of fungal strains Trichophyton rubrum and T. mentagrophytes (2018)

The side effects of skin disease antibiotics and lengthy periods of therapy are major shortcomings of both old and newly developed ranges of antifungals. Hence, there is a need to develop an effective, cheap and readily available antifungal of a natural origin to combat skin diseases. The aim of this study was to investigate the effect of Agathosma betulina and Coleonema album essential oil (EO) on the growth and morphology of two fungal strains (Trichophyton rubrum and T. mentagrophytes) responsible for ringworm, and analyse the components of the EO of both plants. There was inhibition/reduction of fungal growth in all plates exposed to EO volatiles. However, the rates of inhibition varied among the fungal species, EO and different volumes tested. The volatiles from A. betulina EO showed a remarkable inhibitory effect with the highest inhibition recorded at 40 μl. The best inhibition was recorded in T. rubrum exposed to volatiles at 40 μl of A. betulina EO with a fungal growth index of 2.3%, indicating its ability of strong fungicidal effects. The mode of action of the EO volatiles was elucidated using electron microscopy. The volatiles inhibited fungal growth by inhibiting the production of spores. Agathosma betulina EO (40 μl) resulted in the destruction of hyphae and spores of T. rubrum. The major components of the EO of A. betulina were limonene (29.8%), menthone (21.6%), and isomenthone (14.7%), while of C. album were pinene (27.4%), and myrcene (14.5%).
Onset of allergy and asthma symptoms in extra‐European immigrants to Milan, Italy: possible role of environmental factors (2003)

Most extra-European immigrants declared that they were healthy at home and that allergy and asthma symptoms had appeared after immigration to Milan; lifestyle and environmental factors in a western industrialized city seem indeed to facilitate allergy/asthma onset in immigrants from developing countries. Allergy/asthma risk seems to be different in different ethnic groups.
Genotypic and Phenotypic Evolution of a Murine Tumor During Its Progression In Vivo Toward Metastasis<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref> (1983)

To follow the cellular progeny of the multiple-drug-marked benign murine tumor cell line MDW4 during its progression in vivo toward metastatic spread in DBA/2 mice, the following parameters were analyzed: retention of the drug-resistant markers ouabain resistance (OuaR) and thioguanine resistance (ThgR), lectin-resistance pattern (WGAR), and the karyotype of cell populations (and clones derived from these cells) removed at intervals from the solid tumor growing at the site of inoculation, as well as distant metastatic nodules. It was determined that the initially homogeneous inoculum composed of OuaR, ThgR, and WGAR hypotetraploid cells (mode: 68 +/- 2 chromosomes) was gradually overgrown and replaced by a new population of cells that were either OuaR or ouabain-sensitive but that became thioguanine-and lectin-sensitive and hyperploid (mode: 95 +/- 5). Regardless of the composition of the individual drug marker combinations, only cells with high chromosome contents were found to be able to disseminate to distant visceral organs and to rapidly produce metastases upon sc or iv reinjection. The presence of the same number of metacentric chromosomes in metastatic cells as in MDW4 and the coextinction of two recessive drug-resistant markers (WGAR and ThgR) suggested that cells endowed with invasive-metastatic potential represent the product of spontaneous somatic hybridization between the original nonmetastatic MDW4 cells and normal host cells of unknown origin. Such a fusion was followed by more or less extensive chromosome segregation that accounts for the karyotype mosaicism and the occasional drug marker heterogeneity identified in cell populations of metastatic nodules.
Familial Pheochromocytoma, Medullary Thyroid Carcinoma, and Parathyroid Adenomas (1970)

In a patient with bilateral malignant familial pheochromocytomas, medullary thyroid cancer, and parathyroid adenomas (Sipple's syndrome), high concentrations of calcitonin were assayed in the medullary cancer. A striking morphological similarity is noted between the medullary thyroid carcinoma and the metastases from the pheochromocytoma in this patient. The recently reported discovery of a calcitonin-like substance in the adrenal medulla and the morphological similarities between the pheochromocytomas' metastases and the calcitonin producing thyroid cancer are considered as evidence in support of the concept that this syndrome is a defect in a single (neuroectodermal) cell system.
Growth performance of nursery pigs fed BIOSAF yeast, alone or in combination with an in-feed antimicrobial (2005)

A total of 280 pigs were used in a 28-d growth study to evaluate the effects of feeding the antimicrobial carbadox, BIOSAF (0.4%), and the combination of carbadox and BIOSAF yeast (0.15%) in nursery pig diets. Over the length of the entire trial, pigs fed the diet containing carbadox alone had greater ADG than did pigs fed the control diet or the diet containing 0.4% BIOSAF. Overall, pigs fed the diet containing both carbadox and 0.15% BIOSAF had greater ADG than did pigs fed the control diet or the diet containing 0.4% BIOSAF (P<0.04), although their growth performance did not differ from that of pigs fed carbadox alone. Antibody titers in response to routine vaccination against Mycoplasma hyopneumoniae were not affected by dietary treatment. There was no evidence that BIOSAF improved growth performance of nursery pigs, either alone or in combination with the carbadox. It is possible that the interactive effects of BIOSAF that have been reported for other in-feed antibiotics are not present when BIOSAF is combined with carbadox, or perhaps interactive effects are only observed when carbadox itself exerts a more potent stimulation of ADG in nursery pigs.; Swine Day, 2005, Kansas State University, Manhattan, KS, 2005