gebhart/patrepeval huggingface dataset:
HLA DOA1 and DOB1 loci in Honduran women with cervical dysplasia and invasive cervical carcinoma and their relationship to human papillomavirus infection. (1999)

Molecular and epidemiological studies have demonstrated that certain types of human papillomavirus (HPV), mainly HPV-16 and HPV-18, are the primary causes of cervical cancer and its precursor lesions; there is now evidence for a clear association with specific HLA class I and class II loci contributing independently to the expression of cervical cancer. Among Honduran women carcinoma of the cervix is the most common type of cancer, and infections with high-risk HPV types are highly prevalent. To study the interactive role of viral-host genetics, we performed PCR amplification of DNA and sequence-specific oligonucleotide probe typing on cervical scrapes from 49 women [24 with cervical intraepithelial neoplasia stage III or cervical cancer (severe cases) and 25 with stage I or II cervical intraepithelial neoplasia (mild cases)] and 75 control subjects to look for possible associations between HPV and HLA class II DQA1 and DQB1 alleles in the development of dysplasias and invasive cancer. This analysis revealed a predominance of HLA-DQA1*0301 among severe-case patients [relative risk (RR) = 3.45, p = 0.008), whereas DQA1*0501 was negatively associated (RR = 0.30, p = 0.03), suggesting a protective effect of this allele. HPV typing showed a decreased relative risk among the HPV-16 or HPV-18 carrying patients and other HPV-related positive patients in the presence of DQB1*0602 compared with positive control subjects (p = 0.04). No statistically significant allele frequency difference was observed between mild dysplasia cases and control subjects. The results suggest that DQA1*03011, which is in linkage desequilibrium with all HLA-DR4 alleles, confers an increased risk for severe cervical dysplasia and invasive cancer, whereas DQA1*0501, which is in several DR52 haplotypes, has a protective effect. Furthermore, specific HLA-DQB1 sequences may be important in determining the immune response to HPV peptides and may affect the risk for cervical cancer after HPV infection in mestizo Honduran women.
Analysis of Users' Gestures by Application in Smartphone Touch Interfaces (2015)

Touch interface is widely used in a smartphone instead of a keyboard or a keypad interface that has been adopted in a PC or a featurephone, respectively. Touch interface can recognize a variety of gestures that clearly represent the distinct features of each application`s input. This paper analyzes users` gesture of each application captured by the touch interface of a smartphone. Specifically, we extract touch input traces from various application categories such as game, web browser, youtube, image and e-book viewer, video player, camera, and map applications, and then analyzed them. Through this analysis, we observed a certain unique characteristics of each application`s touch input, and this can be utilized in various useful areas such as identification of an application user, prevention of running an application by an illegal user, or design of a new interface convenient to a specific user.
Tunability of one-dimensional self-faceting on GaAs (311)A surfaces by metalorganic vapor-phase epitaxy (1994)

The controlled step bunching on GaAs (311)A oriented surfaces during growth by metalorganic vapor-phase epitaxy (MOVPE) leads to one-dimensional faceting with a lateral period tunable upon growth temperature and layer thickness in the mesoscopic size range 25–80 nm. The surface morphology established during MOVPE growth directly images the microscopic surface structure maintained during growth by conventional solid source molecular beam epitaxy (MBE) and allows us to control the lateral period in GaAs/AlGaAs wire-like heterostructures. The red shift of the luminescence at room temperature from these structures is directly correlated with the lateral period of faceting.
Analysis of Problems in the Clinical Application of Chinese Medicine (2011)

Through checking cases of Tongchuan People's hospital from January to December of 2009 and clinical checking findings,to analyze irrational reasons of Chinese medicine in the clinical application,and proposed solutions,in order to provide clinical reference for the rational application of Chinese medicine.
Supplementary Figure1 from Modeling High-Grade Serous Ovarian Carcinoma Using a Combination of <i>In Vivo</i> Fallopian Tube Electroporation and CRISPR-Cas9–Mediated Genome Editing (2023)

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Conception d'un système de charge par induction de 22kW avec un fort espacement inducteur/induit (2018)

International audience
Development of anatomically realistic PET and PET/CT phantoms with rapid prototyping technology (2007)

The utility of PET and PET/CT in research and diagnosis of cancer, cardiac and neurological disorders has been widely demonstrated. Phantoms with well defined geometries that accurately model radiolabeled tracer concentrations and photon attenuation coefficients are suited for characterization of imaging systems, but not as well suited for evaluating methods sensitive to detailed anatomical structure, such as algorithms for monitoring tumor response. An ideal phantom would have the shape and activity distribution of a realistic tumor and would be useful in evaluation of automated image analysis systems. Such a phantom, imaged at sites involved in clinical trials, would be valuable for evaluating consistency and accuracy. We have developed a method of creating such phantoms by incorporating radioactive tracer as dye for a cellulose powder based rapid prototyping system. This allows us to create phantoms with spatial resolution limited only by the stereolithography printer system (slice thickness is 0.18 mm, printing resolution is 600 dpi). We have evaluated the method by printing several small phantoms with 18F and measuring activity in a gamma counter. The relative standard deviation of the activity of multiple identical phantoms was 2%. Activity in unlabeled parts was less than 2% of adjacent labeled regions. We have created and printed realistic phantoms based on the SPL human brain atlas [1,2], the Paxinos & Watson rat brain atlas [3] and from PET/CT images of human lung nodules, showing that this is a practical method for making complex radioactive phantoms that model real anatomy. We are proceeding with further development to allow us to produce phantoms with multiple activity concentrations, tunable photon attenuation coefficients and long lived isotopes.
Spin-valve effects in a semiconductor field-effect transistor: A spintronic device (1999)

We present a spintronic semiconductor field-effect transistor. The injector and collector contacts of this device were made from magnetic permalloy thin films with different coercive fields so that they could be magnetized either parallel or antiparallel to each other in different applied magnetic fields. The conducting medium was a two-dimensional electron gas (2DEG) formed in an AlSb/InAs quantum well. Data from this device suggest that its resistance is controlled by two different types of spin-valve effect: the first occurring at the ferromagnet-2DEG interfaces; and the second occurring in direct propagation between contacts.
The Role of Virtual Rehabilitation in Total Knee and Hip Arthroplasty. (2018)

Virtual rehabilitation therapies have been developed to focus on improving care for those suffering from various musculoskeletal disorders. There has been evidence suggesting that real-time virtual rehabilitation may be equivalent to conventional methods for adherence, improvement of function, and relief of pain seen in these conditions. This study specifically evaluated the use of a virtual physical therapy/rehabilitation platform for use during the postoperative period after total hip arthroplasty (THA) and total knee arthroplasty (TKA). The use of this technology has the potential benefits that allow for patient adherence, cost reductions, and coordination of care.
Synthesis and Reactivity of Bis(phospholyl)neodymium(III) and -samarium(III) Chlorides and Alkyl Derivatives (1999)

The reaction of 2,3,4,5-tetramethylphospholylpotassium [C4Me4PK] with [LnCl3(THF)x] (Ln = Nd, Sm) in a 2:1 ratio gave unsolvated ate complexes of the formula [(C4Me4P)2LnCl2K]. Crystallisation of the samarium complex from ether afforded a polymeric ether solvate: {[(η5-C4Me4P)Sm(μ3-Cl)2(μ:η5,η1-C4Me4P)K(Et2O)]∞}, which was characterised by X-ray crystallography. Reaction of [(C4Me4P)2LnCl2K] with [LiCH(SiMe3)2] in toluene gave the alkyl complexes [(C4Me4P)2LnCH(SiMe3)2]; these complexes were most efficiently prepared from [LnCl3(THF)x], [KC4Me4P] and [LiCH(SiMe3)2] in a one-pot procedure. Reaction of [(C4Me4P)2LnCH(SiMe3)2] with molecular hydrogen gave [(C4Me4P)2NdH], when Ln = Nd, whereas, when Ln = Sm, reduction occurred and the already known [(C4Me4P)2Sm] was isolated instead.
Solitary intraosseous myofibroma of the tibia in an adult patient: A case report (2014)

Myofibromas are mesenchymal tumors showing myofibroblastic differentiation and found most frequently in the head and neck region. While several cases of myofibromas have been reported in adults, they have not been described in long bones of the appendicular skeleton. We describe an otherwise healthy young woman who presented with a progressive incapacitating pain in her right shin. Imaging studies revealed a well-circumscribed osteolytic lesion with slight marginal sclerosis confined to the proximal tibia metaphysis, without a soft tissue component. Surgical intervention was performed and histological examination identified a myofibroma. This case represents an extremely rare occurrence of an intraosseous myofibroma involving a long bone in an adult patient. Although solitary myofibroma is a rare lesion in the skeletal bones of adults we believe it should be included in the differential diagnosis of a solitary lytic mass in bone, especially if it is associated with pain.
Superior overall survival (OS) and disease-free survival (DFS) predictions for patients with glioblastoma multiforme (GBM) using Cellworks Singula: myCare-022-03. (2021)

2017 Background: The Cellworks Singula Therapeutic Response Index (TRI) has been developed to assist clinicians and GBM patients in choosing between competing therapeutic options. In contrast to approaches that consider single aberrations, which often yield limited benefit, Cellworks utilizes an individual patient’s next generation sequencing results and a mechanistic multi-omics biology model, the Cellworks Omics Biology Model (CBM), to biosimulate downstream molecular effects of cell signaling, drugs, and radiation on patient-specific in silico diseased cells. For any individual patient and alternative therapy, Cellworks integrates this biologically modeled multi-omics information into a continuous Singula TRI Score, scaled from 0 (low therapeutic benefit) to 100 (high therapeutic benefit). We demonstrate that Singula is strongly associated with OS and DFS beyond standard clinical factors, including patient age, patient gender, and physician prescribed treatments (PPT). Methods: In this study, Singula’s ability to predict response was evaluated in a retrospective cohort of 100 GBM patients with OS and DFS data from The Cancer Genome Atlas (TCGA) project, treated with PPT. As a primary analysis of the CBM and TRI Score, Cox Proportional Hazards (PH) regression and likelihood ratio (LR) tests were used to assess the hypothesis that Singula is predictive of OS and DFS above and beyond patient age, patient gender, and PPT. A p-value &lt; 0.05 for the corresponding likelihood ratio statistic was required to be considered significant. Results: Multivariate analyses were performed to assess the performance of the Singula Therapy Response Index after adjusting for the contribution of standard clinical factors. The same Singula TRI algorithm and clinical cutoffs were used for all clinical outcome measures. These analyses, shown in the table, suggests that the proposed Singula TRI provides predictive value of OS and DFS above and beyond patient age, patient gender, and PPT. Conclusions: The Singula TRI Score provides a continuous measure scaled from 0 (low benefit) to 100 (high benefit) for alternative GBM therapeutic options. In this retrospective cohort, Singula was strongly predictive of OS and DFS and provided predictive value beyond PPT, patient age and gender. These results will be further validated in larger scale, prospectively designed clinical studies.[Table: see text]
Yeast pheromone pathway modeling using Petri nets (2014)

The simulation results reveal that a cell can overcome the detrimental effects of the conditions by using more concentration of additional proteins in λ. The first two experiments provide evidence that employing more concentration of proteins might be one of the ways that the cell uses to adapt itself in inhibiting conditions to facilitate mating. The results of the third experiment reveal that in some case the protein set σ is sufficient in regulating the response of the cell. Results of Experiments 4 and 5 reveal that there are certain conditions (parameters) in the model that are more important in determining whether a cell will respond positively or not.
ACryp-Proc: Flexible Asymmetric Crypto Processor for Point Multiplication (2018)

Flexibility is one of the driving agents for 5G architecture development to incorporate enhanced mobile broad band, machine type communication (MTC), and ultra-reliable MTC. While considering flexibility in the domain of security/reliability, we present a unified and flexible hardware architecture, implementing point multiplication algorithm for both elliptic curve cryptography (ECC) and Binary Huff Curves (BHC). The proposed architecture can be used in the scenarios where the users can tradeoff between the algorithmic execution time and different reliability/security levels. To establish an area overhead for the unified design, dedicated architectures for ECC and BHC over the GF(2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</sup> ) field are implemented in the first step and compared with state-of-the-art. Then, a unified architecture for ECC and BHC is implemented. The performance results of proposed unified architecture illustrate the trade-off between execution time and security level.
Permanent-Magnet Synchronous Machine model for urban transport applications (2010)

Permanent-Magnet Synchronous Machines (PMSM) become more and more interesting for urban transport applications (tramways and busses with electric drives), because performance increases at decreasing cost. Their compact design facilitates customer-friendly low-floor design and reduces weight, the efficiency at rated power can be by about 3 percent higher. Demands concerning ruggedness can be fulfilled by interior permanent-magnet (IPMSM) design. Sufficient field-weakening capability by negative d-stator current component allows for a suitable speed range with constant power and for emergency braking. Adequate real-time control systems with high torque dynamics require suitable models of the machine. A high level of complexity, like in finite-element models, cannot be used because of limited calculation time. If the model is too simple, important effects are neglected, for example the reluctance torque of IPMSM. The model should also give the main parameters for the operation of the machine and allow the rating of the converter feeding the machine. With special respect to field weakening and reluctance torque, optimal operation points have to be identified, taking into account the limited rating of the converter. For this, special conditions of light-rail applications like emergency braking are considered. In this way the machine can be operated with high efficiency at minimal losses of machine and converter and fulfill the demanding conditions of urban transport applications. This paper gives a suitable model for the IPMSM fulfilling the above requirements and suggests suitable areas of operation based on an example machine.
In Search of Rt: Limits and Possibilities (1997)

In locating hydrocarbon, electrical logging techniques play a key role in distinguishing between oil and water saturated rocks. Among the electrical techniques, two classes of devices, induction and current injection (galvanic), are of significant importance in determining movable and residual hydrocarbons. In the past, the borehole electrical logs have been mostly interpreted using curve matching or approximate modeling techniques. This often resulted in underestimating the hydrocarbon and/or in false distinction between water- and oil-bearing zones. Here, we present an automated interpretation technique which has become feasible to the oil industry with the advancement in geophysical inversion and modeling and the advent of small parallel computers. In addition to an automated and more reliable interpretation, one can combine numerous different electrical measurements to avoid the inherent bias of the individual logging tools. Further, a thorough analysis of the interpretation methodologies used (namely inversion) allows us to provide uncertainty estimates for the interpretation results which can be translated directly into minimum and maximum pay values. The benefits of this technology are presented using case histories from different environments.
Immunosuppressive tumor-infiltrating myeloid cells mediate adaptive immune resistance via a PD-1/PD-L1 mechanism in glioblastoma (2016)

Together, these studies elucidate the role that TIMs play in mediating adaptive immune resistance in the GBM microenvironment and provide evidence that they can be manipulated pharmacologically with agents that are clinically available. Development of immune resistance in response to active vaccination in GBM can be reversed with dual administration of CSF-1Ri and PD-1 mAb.
3D-FISH on Cultured Cells Combined with Immunostaining (2010)

Fluorescence in situ hybridization on three-dimensionally preserved nuclei (3D-FISH), in combination with immunocytochemistry and 3D fluorescence microscopy, is a key tool to analyze the functional organization of the interphase nucleus. In the last decade, 3D-FISH on cultured cells has become a routine technique and is now widely used in nuclear biology. This method allows visualization of chromosome territories, chromosome subregions, single genes, and RNA transcripts preserving their spatial positions in the cell nucleus. In many cases, it is desirable to combine 3D-FISH and immunostaining to map DNA/RNA and protein targets in the same cells. Some steps of the FISH procedure, however, may interfere with immunostaining and special efforts have to be done to combine FISH and antibody staining successfully. The protocol suggested in this chapter describes three variants of combined 3D-FISH and immunostaining which have been successfully used in our laboratory for many years.
In-vitro activity of ofloxacin against isolates of Neisseria gonorrhoeae (1988)

A total of 1186 clinical isolates of Neisseria gonorrhoeae were tested for in-vitro disc susceptibility to ofloxacin, one of the new generation of fluorinated quinolones. All isolates appeared susceptible. Minimum inhibitory concentrations were determined for a random sample of 122 strains and all were equal to or less than 0.02 mg/l.
Dimerization of the guanine-adenine repeat strands of DNA (1999)

Jovin and co-workers have demonstrated that DNA strands containing guanine-adenine repeats generate a parallel-stranded homoduplex. Here we propose that the homoduplex is a dimer of the ordered single strand discovered by Fresco and co-workers at acid pH. The Fresco single strand is shown here to be stabilized in aqueous ethanol where adenine is not protonated. Furthermore, we demonstrate that the strands dimerize at higher salt concentrations without significantly changing their conformation, so that the dimerization is non-cooperative. Hence, the Jovin homoduplex can form through a non-cooperative dimerization of two cooperatively melting single strands. The available data indicate that the guanines stabilize the Fresco single strand whereas the adenines cause dimerization owing to their known intercalation or clustering tendency. The guanine-adenine repeat dimer seems to be a DNA analog of the leucine zipper causing dimerization of proteins.
The Microstructure of Aging ZnO, AZO, and GZO Films (2014)

RF magnetron sputtering is used on the ceramic targets, each of which contains zinc oxide (ZnO), zinc oxide doped with aluminum (AZO) and zinc oxide doped with gallium (GZO). The electric conduction mechanism of the AZO and GZO films came mainly from the Al and Ga, the oxygen vacancies, Zn interstitial atoms, and Al and/or Ga interstitial atoms. AZO and GZO films achieved higher conduction than did ZnO film, it being ion vacant and nonstoichiometric. The XRD analysis showed a preferred orientation along the (002) plane for ZnO, AZO, and GZO films.
Chlamydia trachomatisInfection of Human Mesothelial Cells Alters Proinflammatory, Procoagulant, and Fibrinolytic Responses (1998)

In this study we demonstrate the capability of Chlamydia trachomatis to infect cultured human mesothelial cell (MC) monolayers and to induce the production of the proinflammatory cytokines interleukin 1beta (IL-1beta) and IL-8. Seventy-two hours after initial infection, both the procoagulant activity of MC and the activity of the fibrinolytic inhibitor (plasminogen activator inhibitor 1) in the supernatants were enhanced. These findings support the hypothesis that provoked proinflammatory responses contribute to the development of complications after chlamydial infection.
Mesh Merging with Mean Value Coordinates (2012)

Merging a source mesh to a target mesh is one useful and important mesh operating technology. This paper introduces a method merging with mean value coordinates. The method firstly computes the mean value coordinates of the vertices in the source mesh with respect to its boundary. After specifying the difference between the two mesh's boundaries, it interpolates the difference of the source's inside vertices through the coordinates, and then constructs a new mesh to merge. With the same framework, smoothing the seaming line can be achieved by interpolating tangent vector variations. This method avoids the mesh parameterizations or the solving a large linear system, but does merge through computing close form expressions. Experiments show that mesh merging with this method is less artifacts and faster, comparing to the method through solving Poisson equation.
Threshold Values Of Indicators for Diagnostics of Economic Security the Russian Federation at the Present Stage (2019)

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Dynamic Analysis of Three-Dimensional Frames with Material and Geometric Nonlinearities (2010)

The dynamic analysis of inelastic structures with geometric nonlinearities experiencing large deformations and buckling is challenging, in particular, if three-dimensional space effects are considered. This paper introduces a new formulation of a three-dimensional beam-column element and the associated analysis of the global frame system using a corotational approach formulated in the state space. The corotational approach may allow uncoupling of the local large deformations and inelastic buckling of the element from the large deformation of the global system. Shaking table testing performed by the authors on a steel frame model structure provides benchmark information for comparison with the proposed analytical formulation.