gebhart/patrepeval huggingface dataset:
Collagenase to facilitate guidewire crossing in chronic total occlusion PCI—The Total Occlusion Study in Coronary Arteries‐5 (TOSCA‐5) trial (2022)

Local delivery of MZ-004 into coronary CTOs appears safe and may facilitate CTO crossing, particularly with softer tipped guidewires. These data support the development of a pivotal trial to further evaluate this agent.
Agent-based Models as a Method to Analyse Privacy-friendly Business Models in an Assistant Ecosystem (2020)

Various projects and initiatives strive towards designing privacy friendly open platforms and ecosystems for digital products and services. However, besides mastering technical challenges, achieving economic viability and broad market success has so far proven to be difficult for these initiatives. Based on a publicly funded research project, this study focuses on the business model design for an open digital ecosystem for privacy friendly and trustworthy intelligent assistants. We present how the agent-based modelling technique can be employed to evaluate how business models perform in various constellations of an open digital ecosystem. Thus, our work relates to the strategic choice of suitable business models as an important success factor for privacy and security-relevant technologies.
Mismatch repair deficiency endows tumors with a unique mutation signature and sensitivity to DNA double-strand breaks (2014)

DNA replication errors that persist as mismatch mutations make up the molecular fingerprint of mismatch repair (MMR)-deficient tumors and convey them with resistance to standard therapy. Using whole-genome and whole-exome sequencing, we here confirm an MMR-deficient mutation signature that is distinct from other tumor genomes, but surprisingly similar to germ-line DNA, indicating that a substantial fraction of human genetic variation arises through mutations escaping MMR. Moreover, we identify a large set of recurrent indels that may serve to detect microsatellite instability (MSI). Indeed, using endometrial tumors with immunohistochemically proven MMR deficiency, we optimize a novel marker set capable of detecting MSI and show it to have greater specificity and selectivity than standard MSI tests. Additionally, we show that recurrent indels are enriched for the 'DNA double-strand break repair by homologous recombination' pathway. Consequently, DSB repair is reduced in MMR-deficient tumors, triggering a dose-dependent sensitivity of MMR-deficient tumor cultures to DSB inducers.
El potencial exportador peruano y estrategias del sector en el corto, mediano y largo plazo (2017)

La base del comercio exterior de nuestro pais, tradicionalmente se sustenta en la exportacion de recursos naturales o materias primas (comodities entre minerales, productos agricolas e hidrocarburos) dado que del total de las exportaciones nacionales a diciembre del 2013, segun el BCRP, el 78% corresponden a este tipo de exportaciones y la diferencia, es decir tan solo el 22%, corresponden a las exportaciones no tradicionales (ENT), estas ultimas compuestas por productos manufacturados, agroindustriales y pesqueros. No obstante, en los ultimos anos, nuestro pais ha mejorado de manera sustantiva la estructura participativa de las ENT en el total de exportaciones, pues estas al ano 2012, habian alcanzado los US $ 11, 197 millones, comparado con el ano 2002, de US $ 2, 260 millones, lo cual significa un incremento de casi 400% en 10 anos.
Stereochemical aspects of iron tricarbonyl (1,4-dimethyltetraazabutadiene) and related complexes (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereochemical aspects of iron tricarbonyl (1,4-dimethyltetraazabutadiene) and related complexesCurtis E. Johnson and William C. TroglerCite this: Inorg. Chem. 1982, 21, 1, 427–429Publication Date (Print):January 1, 1982Publication History Published online1 May 2002Published inissue 1 January 1982https://pubs.acs.org/doi/10.1021/ic00131a078https://doi.org/10.1021/ic00131a078research-articleACS PublicationsRequest reuse permissionsArticle Views50Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An Interpretative Log Analysis Computer System (1969)

Abstract This paper describes a computer software system recently developed for use of well logs in regional exploration and mapping. The system enables a log analyst to develop two-dimensional areal contour maps of requested exploration criteria from a file of digitized well log data. The backbone of the system is an efficient computer procedure for recognizing and "compiling" the computations specified by the analyst. The desired computational processes are supplied as part of the input data in the form of algebraic or logical statements. The software system compiles the statements on data cards, translating them to psuedo-machine code. An efficient interpreter then is able to execute the analyst's statements. If an algorithm proves to be useful repetitively, means are available to include it within the permanent system. Thus a log analyst can use the permanent system. Thus a log analyst can use the system as a convenient laboratory to develop improved exploration techniques. Input from the analyst into the system could be of batch type or through time-sharing terminals. Output includes line printer tables, plots and contour maps. The software system is described in detail and examples of its use are given. Introduction Several papers have appeared in the literature during the past five years describing computer software systems for quantitative evaluation of well logs. The first systems to be developed were those that computed values for variables such as water saturation, porosity and shaliness for a single set of data from one zone. The data was manually selected from the analog print normally obtained at the well site. The second generation of systems were those that operated on a larger set of data—in general the digitized data from all traces throughout a large portion of the well were used.
Highly Stable, Low Redox Potential Quinone for Aqueous Flow Batteries** (2022)

Abstract Aqueous organic redox flow batteries are promising candidates for large‐scale energy storage. However, the design of stable and inexpensive electrolytes is challenging. Here, we report a highly stable, low redox potential, and potentially inexpensive negolyte species, sodium 3,3′,3′′,3′′′‐((9,10‐anthraquinone‐2,6‐diyl)bis(azanetriyl))tetrakis(propane‐1‐sulfonate) (2,6‐N‐TSAQ), which is synthesized in a single step from inexpensive precursors. Pairing 2,6‐N‐TSAQ with potassium ferrocyanide at pH=14 yielded a battery with the highest open‐circuit voltage, 1.14 V, of any anthraquinone‐based cell with a capacity fade rate &lt;10 %/yr. When 2,6‐N‐TSAQ was cycled at neutral pH, it exhibited two orders of magnitude higher capacity fade rate. The great difference in anthraquinone cycling stability at different pH is interpreted in terms of the thermodynamics of the anthrone formation reaction. This work shows the great potential of organic synthetic chemistry for the development of viable flow battery electrolytes and demonstrates the remarkable performance improvements achievable with an understanding of decomposition mechanisms.
Making Fuel While the Sun Shines. (2018)

Recent advances in the production of photovoltaic panels have driven down the cost of solar power. Estimates for the levelized cost of electricity from PV range from 10 to 30 cents per kWh. And though this is still higher than the cost of generation from a newly built coal-fired thermal power station, solar power could be the cheapest electricity available in some areas within a few years, according to data from the Energy Information Agency.
Effects of high temperature during grain filling on physicochemical properties of waxy maize starch (2016)

Understanding the waxy maize starch physicochemical properties response to heat stress during grain filling could improve starch quality. The effects of heat stress during early (1–15 days after pollination, DAP) and late (16–30 DAP) grain filling stages on the starch physicochemical properties of four waxy maize varieties were evaluated. Crystallinity only increased in Suyunuo 5 after exposure to high temperature at late grain filling stage. The effects of heat stress on digestibility and swelling power were dependent on varieties and stages. Generally, swelling power was increased by heat stress at early grain development stage and digestibility was increased by high temperature at late grain filling stage, respectively. The results of correlation analysis indicated the starch with large granule size could swell well and easy digest. Peak, trough, final, and breakdown viscosities in response to heat stress were dependent on stages and varieties. In general, peak, trough and final viscosities were decreased and increased by heat stress at early grain formation and late grain filling stages, respectively; whereas the breakdown and setback viscosities were similar among the three treatments. Heat stress increased the gelatinization temperatures and retrogradation percentage. Gelatinization range decreased under heat stress at 1–15 DAP but remained constant under heat stress at 16–30 DAP in all varieties. The starch exposed to high temperature at 16–30 DAP presented higher digestibility and peak viscosity and lower retrogradation percentage than those at 1–15 DAP. Therefore, heat stress at early grain formation stage severely affects the physicochemical properties of starch.
Tying Up the Solar System With a Ribbon of Charged Particles (2009)

Five papers published online in Science this week report that NASA's Interstellar Boundary Explorer revealed a sky-spanning "ribbon" of unexpectedly intense emissions of energetic neutral atoms.
A mass spectrometric study of secondary organic aerosols formed from the photooxidation of anthropogenic and biogenic precursors in a reaction chamber (2006)

Abstract. An Aerodyne Aerosol Mass Spectrometer (AMS) has been utilised to provide on-line measurements of the mass spectral signatures and mass size distributions of the oxidation products resulting from irradiating 1,3,5-trimethylbenzene (1,3,5-TMB) and α-pinene, separately, in the presence of nitrogen oxide, nitrogen dioxide and propene in a reaction chamber. Mass spectral results indicate that both precursors produce SOA with broadly similar chemical functionality of a highly oxidised nature. However, significant differences occur in the minor mass spectral fragments for the SOA in the two reaction systems, indicating that they have different molecular composition. Nitrogen-containing organic compounds have been observed in the photooxidation products of both precursors, and their formation appeared to be controlled by the temporal variability of NOx. Although the overall fragmentation patterns of the photooxidation products in both systems did not change substantially over the duration of each experiment, the contribution of some individual mass fragments to total mass appeared to be influenced by the irradiation time. The effective densities of the 1,3,5-TMB and α-pinene SOA particles were determined for various particle sizes using the relationship between mobility and vacuum aerodynamic diameters. The effective density for the 1,3,5-TMB SOA ranged from 1.35–1.40 g/cm3, while that for α-pinene SOA ranged from 1.29–1.32 g/cm3. The determined effective densities did not show dependence on irradiation time. Results suggest that further chemical processing of SOA takes place in the real atmosphere, as neither the α-pinene nor the 1,3,5-TMB experimental results reproduce the right relative product distribution between carbonyl-containing and multifunctional carboxylic acid species measured at ambient locations influenced by aged continental organic aerosols.
Minimally Invasive Coronary Artery Bypass Grafting: A New Method Using an Anterior Mediastinotomy (1995)

The benefit of internal mammary artery (IMA) grafting as a long-lasting intervention for coronary artery disease is well recognized. However, largely because they are less invasive, catheter based alternatives are frequently chosen, particularly to treat single or double vessel disease. To retain the advantages of the IMA graft, and to offset the invasiveness of conventional coronary artery bypass grafting, we developed a new minimally invasive method using an anterior mediastinotomy for treating left anterior descending (LAD) or right coronary artery disease, or both. Feasibility studies using 16 pigs and a human cadaver led to approval by the Institutional Review Board for use of this procedure to treat six patients (four men, two women; mean age, 63.8 +/- 13.6 [SD] yrs) who granted informed consent. Pedicle dissection of the IMA, using video assisted thoracoscopy if necessary, was made through a 2- to 3-inch horizontal anterior mediastinotomy. The underlying LAD artery was grafted during femoral vessel cardiopulmonary bypass, with cooling to 30 degrees C, induced ventricular fibrillation, and left ventricular venting if required. Transesophageal echocardiography performed after bypass showed that two patients maintained normal wall motion and four had improvement from the original impairment. One patient suffered a recurrence of angina 4 weeks after the procedure; recatheterization showed an acutely angled IMA, subsequently corrected by balloon angioplasty. The results of follow-up dobutamine echocardiographic stress tests were negative in all patients. With this minimally invasive approach, the procedure should provide the benefits of IMA grafting with shorter hospital stay, more rapid recovery, and less overall cost.
Isonitrile, XIII. Kondensation von primären Aminen und Ketonen mit Isonitrilen und Rhodanwasserstoffsäure (1963)

Abstract Die Konstitution des Reaktionsproduktes Ib aus Isopropylamin und Cyclohexanon mit Cyclohexylisocyanid und Rhodanwasserstoffsäure wird durch reduktive und oxydative Entschwefelung sowie durch Hydrolyse aufgeklärt. Anhand weiterer Beispiele wird der Anwendungsbereich der α‐Aminoalkylierung von Isonitrilen und Rhodanwasserstoffsäure erläutert.
The Proximally Based Peroneal Vascular Bundle (2009)

Large, traumatic wounds around the proximal third of the lower extremity may have disrupted local vasculature, potentially obviating local pedicled options. However, free-tissue transfer to this area is technically challenging given the resulting paucity of recipient options and the depth of principal blood vessels. We present an anatomic and radiographic study of the proximally based peroneal vascular bundle as a recipient option in the proximal leg. Optimal approach was prone, through an incision over the fibula with dissection between lateral and posterior compartments. Magnetic resonance angiography demonstrated consistent vascular anatomy between patients. A proximally based peroneal vascular bundle protected by a cuff of flexor hallucis longus was used as a recipient vessel in free flap reconstruction of an open knee wound. The bundle itself does not require coverage by virtue of its own local muscle cuff. Caveats for its use include the need for adequate leg inflow and foot outflow.
RF channel modeling of a WSN testbed for industrial environment (2011)

Industrial applications of wireless sensor networks often involve radio-harsh environments. These industrial settings typically include an abundance of metallic structures which obstruct, reflect, refract and scatter signals. As a result, RF channel modeling for these environments becomes necessary and important. In this paper, a WSN testbed emulating realistic industrial environments was constructed and developed. With it, RF channel propagation properties were measured and analyzed in 2.4GHz and 5.8GHz ISM bands using vector network analyzer.
Power Control for Interference Management and QoS Guarantee in Heterogeneous Networks (2015)

We consider the sum-rate optimization problem with power control for uplink transmission in a heterogeneous network (HetNet) consisting of a macrocell and multiple femtocells. The considered problem includes the HetNet's crucial constraints of both cross-tier interference protection and user QoS in terms of outage probability and average delay. We transform the original nonconvex problem into a convex problem and develop a distributed algorithm that can attain the global optimal transmit power values. This algorithm, however, has heavy network overheads, which may lead to increased energy consumption for femtocell user equipment. We propose a new practical near-optimal distributed algorithm that eliminates these network overheads. Numerical results show that the schemes have nearly identical performance.
<p>Clinical and instrumental evaluation of a new topical non-corticosteroid antifungal/anti-inflammatory/antiseborrheic combination cream for the treatment of mild-to-moderate facial seborrheic dermatitis</p> (2019)

Our results indicate that the study facial cream represents an option to consider when dealing with mild-to-moderate SD, being effective, well-tolerated, and free of significant side effects, as confirmed by clinical and instrumental evaluation.
Overexpression of leucine‐rich repeat‐containing G protein‐coupled receptor 5 in colorectal cancer (2010)

Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) is a 7-transmembrane receptor reportedly expressed in stem cells of the intestinal crypts and hair follicles of mice. Overexpression of LGR5 is observed in some types of cancer; however, there has been no specific assessment in colorectal tumorigenesis. We performed quantitative RT-PCR for LGR5 expression in 37 representative cancer cell lines, and showed that LGR5 mRNA was frequently overexpressed in colon cancer cell lines. Moreover, LGR5 expression was higher in colon cancer cell lines derived from metastatic tumors compared with those from primary tumors. In clinical specimens, there was significant overexpression of LGR5 in 35 of 50 colorectal cancers (CRCs), and in seven of seven sporadic colonic adenomas, compared with matched normal mucosa. This suggests up-regulation of LGR5 from the early stage of colorectal tumorigenesis. LGR5 expression showed marked variation among CRC cases and correlated significantly with lymphatic invasion, vascular invasion, tumor depth, lymph node metastasis, and tumor stage (IIIC vs. IIIB). In addition to cancer cells, crypt base columnar cells of the small intestine and colon were shown by in situ hybridization to express LGR5. This is the first report suggesting the involvement of LGR5, not only in early events but also in late events in colorectal tumorigenesis.
Escape routing design to reduce the number of layers in area array packaging (2000)

High density multilayer substrate technologies are indispensable to accommodate high input/outputs (I/Os) fine pitch area array integrated circuits (ICs), chip scale packages/ball grid arrays (CSP/BGAs) in the coming packaging generation. They must provide not only a high wiring density, but also an acceptable low cost, short turn around time (TAT) and reliability. Reduction of the number of layers is expected to be a reasonable solution for the conflicting demands. General approaches to reduce the layer count have been to decrease the size of the routing line width and spacing. However, they need changes in the manufacturing processes and materials, causing an increased cost. From escape routing design viewpoint, effects of routing manner on the layer count have been studied. A preferential routing creates specific pad geometry resulting in a high wiring efficiency. This effect can be estimated with an increase in the number of lines per layer routable as a contribution of "the hybrid channel," depending on capture pad pitch-pad diameter-line width-interline space relationship. It is one of the remarkable cases recognized that, within one line per channel rule, the preferential routing can be almost equivalent to that by two lines per channel with regard to the wireability. Its better effect on cost and TAT can also be expected compared with the two thinner sized lines per channel rule, since nothing changes in both manufacturing processes and materials is needed. This method is applicable immediately to packages and boards for assembly of the high I/O flip chips, CSPs, and BGAs.
What Lies Beneath the Surface: Topological-Shape Optimization With the\n Kernel-Independent Fast Multipole Method (2016)

The paper presents a new method for shape and topology optimization based on\nan efficient and scalable boundary integral formulation for elasticity. To\noptimize topology, our approach uses iterative extraction of isosurfaces of a\ntopological derivative. The numerical solution of the elasticity boundary value\nproblem at every iteration is performed with the boundary element formulation\nand the kernel-independent fast multipole method. Providing excellent single\nnode performance, scalable parallelization and the best available asymptotic\ncomplexity, our method is among the fastest optimization tools available today.\nThe performance of our approach is studied on few illustrative examples,\nincluding the optimization of engineered constructions for the minimum\ncompliance and the optimization of the microstructure of a metamaterial for the\ndesired macroscopic tensor of elasticity.\n
Catalytic antibodies: balancing between Dr. Jekyll and Mr. Hyde (2009)

The immunoglobulin molecule is a perfect template for the de novo generation of biocatalytic functions. Catalytic antibodies, or abzymes, obtained by the structural mimicking of enzyme active sites have been shown to catalyze numerous chemical reactions. Natural enzyme analogs for some of these reactions have not yet been found or possibly do not exist at all. Nowadays, the dramatic breakthrough in antibody engineering and expression technologies has promoted a considerable expansion of immunoglobulin's medical applications and is offering abzymes a unique chance to become a promising source of high-precision "catalytic vaccines." At the same time, the discovery of natural abzymes on the background of autoimmune disease revealed their beneficial and pathogenic roles in the disease progression. Thus, the conflicting Dr. Jekyll and Mr. Hyde protective and destructive essences of catalytic antibodies should be carefully considered in the development of therapeutic abzyme applications.