gebhart/patrepeval huggingface dataset:
Characterizing the Potential of the Non-Conventional Yeast Saccharomycodes ludwigii UTAD17 in Winemaking (2019)

Non-<i>Saccharomyces</i> yeasts have received increased attention by researchers and winemakers, due to their particular contributions to the characteristics of wine. In this group, <i>Saccharomycodes ludwigii</i> is one of the less studied species. In the present study, a native <i>S. ludwigii</i> strain, UTAD17 isolated from the Douro wine region was characterized for relevant oenological traits. The genome of UTAD17 was recently sequenced. Its potential use in winemaking was further evaluated by conducting grape-juice fermentations, either in single or in mixed-cultures, with <i>Saccharomyces cerevisiae</i>, following two inoculation strategies (simultaneous and sequential). In a pure culture, <i>S. ludwigii</i> UTAD17 was able to ferment all sugars in a reasonable time without impairing the wine quality, producing low levels of acetic acid and ethyl acetate. The overall effects of <i>S. ludwigii</i> UTAD17 in a mixed-culture fermentation were highly dependent on the inoculation strategy which dictated the dominance of each yeast strain. Wines whose fermentation was governed by <i>S. ludwigi</i>i UTAD17 presented low levels of secondary aroma compounds and were chemically distinct from those fermented by <i>S. cerevisiae</i>. Based on these results, a future use of this non-<i>Saccharomyces</i> yeast either in monoculture fermentations or as a co-starter culture with <i>S. cerevisiae</i> for the production of wines with greater expression of the grape varietal character and with flavor diversity could be foreseen.
Novel Lymphography Using Indocyanine Green Dye for Near-Infrared Fluorescence Labeling (2007)

Lymphedema is known to be caused by many pathologic conditions; however, its diagnostic and therapeutic strategies remain to be unestablished. In this study, we investigated the usefulness of a novel lymphographic method based on fluorometric sensing using indocyanine green (ICG) dye for imaging lymphatic vessels using rat models. The real-time imaging system enabled visualization of superficial lymphatic vessels with a diameter of 0.1 mm in 33 frames/second. In addition, morphologic changes in lymphatic vessels in a radiation-induced lymphedema model were detected even at the latent stage. These results suggest that this imaging technique is acceptable as an evaluation method for the lymphatic system.
Human cytomegalovirus induces JC virus DNA replication in human fibroblasts. (1993)

JC virus, a human papovavirus, is the causative agent of the demyelinating brain disease progressive multifocal leucoencephalopathy (PML). PML is a rare but fatal disease which develops as a complication of severe immunosuppression. Latent JC virus is harbored by many asymptomatic carriers and is transiently reactivated from the latent state upon immunosuppression. JC virus has a very restricted host range, with human glial cells being the only tissue in which it can replicate at reasonable efficiency. Evidence that latent human cytomegalovirus is harbored in the kidney similar to latent JC virus led to the speculation that during episodes of impaired immunocompetence, cytomegalovirus might serve as helper virus for JC virus replication in otherwise nonpermissive cells. We show here that cytomegalovirus infection indeed leads to considerable JC virus DNA replication in cultured human fibroblasts that are nonpermissive for the replication of JC virus alone. Cytomegalovirus-mediated JC virus replication is dependent on the JC virus origin of replication and T antigen. Ganciclovir-induced inhibition of cytomegalovirus replication is associated with a concomitant inhibition of JC virus replication. These results suggest that reactivation of cytomegalovirus during episodes of immunosuppression might lead to activation of latent JC virus, which would enhance the probability of subsequent PML development. Ganciclovir-induced repression of both cytomegalovirus and JC virus replication may form the rational basis for the development of an approach toward treatment or prevention of PML.
Sudden and Complete Olfactory Loss of Function as a Possible Symptom of COVID-19 (2020)

Giacomo Spinato, MD; Cristoforo Fabbris, MD; Jerry Polesel, MD; Diego Cazzador, MD; Daniele Borsetto, MD; Claire Hopkins, MA(Oxon), DM; Paolo Boscolo-Rizzo, MD
On the application of variable frequency microwave technology for processing of individual surface mount components (2009)

Dual-section variable frequency microwave systems enable rapid, controllable heating of materials within an individual surface mount component in a chip-on=board assembly. The ability to process devices individually allows components with disparate processing requirements to be mounted on the same assembly. The temperature profile induced by the microwave system can be specifically tailored to the needs of the component, allowing optimisation and degree of cure whilst minimising thermomechanical stresses.&#13;\nThis paper presents a review of dual-section microwave technology and its application to curing of thermosetting polymer materials in microelectronics applications. Curing processes using both conventional and microwave technologies are assessed and compared. Results indicate that dual-section microwave systems are able to cure individual surface mount packages in a significantly shorter time, at the expense of an increase in thermomechanical stresses and a greater variation in degree of cure.
Modelo teórico para la reconstrucción de accidentes de tráfico por ordenador (2011)

Los accidentes de trafico se han convertido en uno de los problemas de salud publica mas graves. El objetivo global de esta tesis doctoral es el estudio y desarrollo de un modelo teorico para la simulacion y reconstruccion de accidentes de trafico por ordenador. Tras mostrar unos antecedentes acerca del tema abordado, se desarrolla y explica un lenguaje informatico para a la simulacion de sistemas dinamicos por ordenador, denominado Blove. Utilizando el lenguaje Blove, se desarrollan los modelos vehiculares y de choque necesarios para la simulacion de accidentes de trafico. Se estudia y resuelve el problema del control direccional del modelo de simulacion vehicular, asi como la representacion de la geometria de la calzada. Se desarrolla un algoritmo para la optimizacion de la reconstruccion de accidentes de trafico, que permite hallar la velocidad de los vehiculos en el instante de su colision, en funcion de las consecuencias conocidas del accidente. A continuacion, se describe un sistema informatico de reconstruccion de accidentes de trafico, abordando el problema del tratamiento de los datos necesarios. Por ultimo, se realiza la validacion de los modelos de simulacion desarrollados y del algoritmo de optimizacion de la reconstruccion de accidentes de trafico. Para esta validacion, se utilizan datos de ensayos experimentales de choque y de diversos accidentes de trafico reales. Se acaba exponiendo las conclusiones de esta tesis y las futuras lineas de investigacion que se pueden derivar de ella.
Activated protein kinase C α associates with annexin VI from skeletal muscle (1998)

We have previously detected a number of protein kinase C (PKC) alpha-binding proteins in skeletal muscle cytosol by blot overlay assay, and now identify the major, 69 kDa binding protein as annexin VI by immunoblotting and overlay assay of hydroxyapatite chromatography fractions. Annexin VI was also detected in immunoprecipitates of PKC alpha. Annexin VI and PKC alpha are both calcium-dependent phospholipid-binding proteins, and detection of the interaction was dependent on the presence of calcium and phosphatidylserine (PS). The association probably involves specific protein-protein interactions rather than mere bridging by lipid molecules: firstly, detection of PKC alpha-annexin VI complexes by overlay assay was not diminished when PS concentrations were increased over a 10-fold range, while that of other PKC alpha-binding protein complexes was reduced or abolished; secondly, the presence in the overlay assay of a PKC pseudosubstrate peptide, analogous to a PKC sequence previously found to be involved in PKC binding activity, reduced complex formation; thirdly, we were also able to detect annexin VI interaction with PKC beta by overlay of skeletal muscle cytosol, but not with PKC theta, the major novel PKC in this tissue, suggesting sequences specific to calcium-dependent PKC isoenzymes are involved. While other annexin isoforms may be PKC substrates or inhibitors, annexin VI phosphorylation by PKC alpha could not be detected after co-purification, while phosphorylation of subsequently-added histone IIIS was readily observed. Annexin VI is a major skeletal muscle protein and our data are consistent with a role for this isoform in the control of calcium-dependent PKC.
Distributed Web-Based Assignment Management (2011)

There is an ever-increasing use of computers and applications used by educators for delivering course material. The term ‘courseware’ has been applied to the comprehensive software available to manage many aspects of the delivery process. Until recently, the main thrust of such software has been towards the delivery process and the incorporation of educational material. However, subject management is also an important task carried out by the subject coordinator, and the role it plays in the overall course delivery process should not be underestimated. Although the subject administrative tasks are usually transparent to some degree, if they are performed inefficiently, they become immediately obvious and in the worst case can distract students and staff from the learning process. An instructional system must be backed up by an efficient subject administration system. One administrative task that can consume much of a subject coordinator’s time is assignment management. Assignment management involves collection, date stamping, redistribution to tutors for marking, collation of results, and return of assignments to students. Many such computerized systems have been previously developed, but due to the nature of the infrastructure they were designed for, their use has been awkward and they are not easily transferred from system to system. With the development of the Web since the early 1990s, we now have a ‘standard’ platform used by education and the general community that allows us to build platform independent systems to implement assignment management functionality. Such software provides tangible benefits to both students and subject coordinators.Request access from your librarian to read this chapter's full text.
Review of Glass and Polymer Multimode Fibers Used in a Wimedia Ultrawideband MB-OFDM Radio Over Fiber System (2009)

In this paper, we have exhibited the potential of the glass- and polymer-based multimode fibers to be used in a radio over fiber (ROF) system in order to extend the indoor coverage of the Wimedia multiband orthogonal frequency division multiplexing (MB-OFDM) ultrawideband (UWB) standard. After the design of a test setup operating at 850 nm, we have performed the physical characterization of the ROF system especially the mask test compliance, the error vector magnitude (EVM), or the relative constellation error (RCE) variation as a function of the system parameters [radio frequency (RF) power, optical attenuation, fiber length, laser bias current]. The transmission performance of both 200 and 480 Mb/s Wimedia signals is demonstrated through a 100 m link length of glass- and polymer-based multimode fibers: transmission penalties are quantified by RCE with values under the standard requirements. Two different behaviors depending on the core material of the fiber have been identified in this study.
Supplementary Figure Legends from Inflammation-Dependent IL18 Signaling Restricts Hepatocellular Carcinoma Growth by Enhancing the Accumulation and Activity of Tumor-Infiltrating Lymphocytes (2023)

&lt;p&gt;Legends for Supplementary Figures S1-S19.&lt;/p&gt;
CELLULAR LINEAR-INPUT LOGIC, (1964)

Abstract : A number of different cellualr arrays are proposed and studied in this report. These arrays fall into two structural classes: namely, trees and rectangles. It is shown in the report that they can be used for a wide variety of digital tasks. Some of the more important potential applications of cellular arrays are considered. A connection between cellular arrays and tessellations is also pointed out. Cellular arrays for the production of combinational digital logic are studied. Arrays of majority gates are studied both in terms of trees and rectangles. Methods are developed for synthesizing arbitrary combinational functions with a minimum number of gates, within certain structural assumptions. An adder array is described and studied in this section. These arrays produce several arbitrary combinational functions of a set of input variables. Several theorems are proved relating to the types of possible adder arrays and to the number of cells in them. (Author)
Conditioned and autonomous neoplasms: a review. (1953)

Summary Ideas and investigations are surveyed concerning the stages in the development of neoplasms. It is recognized that alterations in either the host-environment or in the cells can give rise to neoplasms. The former, named conditioned neoplasms, are known to be readily preventable and reversible; the latter, named autonomous neoplasms, are not. Dependency and autonomy are recognized as relative and quantitative terms. Autonomy is never certain. Many autonomous growths pass through a phase of dependent growth, and the usual trend is toward gradual acquisition of greater autonomy. This sequence of events urges greater attention to the study of normal growth-regulating mechanisms and of the very early changes in the evolution of neoplasms. The understanding of these events may ultimately lead to the prophylaxis of some cancers and to their control at their early phases of development.
Induction of C3 and CCL2 by C3a in Keratinocytes: A Novel Autocrine Amplification Loop of Inflammatory Skin Reactions (2006)

The complement fragment-3a (C3a) acts via a G protein-coupled C3aR and is of importance in allergic and inflammatory diseases. Recent studies suggest the presence of complement proteins in the epidermal compartment and synthesis of some of these proteins (C3, factor B, and factor H) by human primary keratinocytes (KCs) during inflammation. However, expression of C3aR and its role in human KCs is not elucidated thus far. In this study, we demonstrate the expression of C3aR on KCs as detected by quantitative real-time RT-PCR and flow cytometry. IFN-gamma and IFN-alpha strongly up-regulated the surface expression of C3aR on KCs among all other cytokines tested. After up-regulation of C3aR by IFN-gamma and IFN-alpha, we observed the induction of five genes (CCL2, CCL5, CXCL8, CXCL10, and C3) after stimulation of KCs with C3a in microarray analysis. We confirmed the induction of C3 and CCL2 at RNA and protein levels. Furthermore, incubation of C3 with skin mast cells tryptase resulted in the generation of C3 fragments with C3a activity. In conclusion, our data illustrate that epidermal KCs express functional C3aR. The increases of C3 and CCL2 synthesis by C3a and C3 activation by skin mast cell tryptase delineates a novel amplification loop of complement activation and inflammatory responses that may influence the pathogenesis of allergic/inflammatory skin diseases.
ANGIOGRAPHIC STUDY OF THE SUBDERMAL PLEXUS: A PRELIMINARY REPORT (2000)

The subdermal plexus was pictured angiographically in five fresh cadavers injected systemically with a lead oxide-gelatin mixture. Subdermal plexus was found either in the subdermal plane or in the deep part of the dermis. Diameters of vessels in the subdermal plexus are not uniform and there are differences in vascular continuity, which means that the subdermal plexus does not always have a random pattern. This observation is important when designing a thin flap.
Decreased pulmonary vascular resistance during nasal breathing: modulation by endogenous nitric oxide from the paranasal sinuses (1998)

Nitric oxide is present in high concentration in the human nasal airways. During inspiration through the nose a bolus is transported to the lungs. In a randomized cross-over study the effect of two different patterns of breathing, nasal breathing and mouth breathing, was evaluated in 10 patients (mean age 65 years), breathing room air the morning of the first post-operative day after open heart surgery. Nasal breathing is defined as inspiration through the nose and expiration through the mouth, whilst mouth breathing is the converse of this: inspiration through the mouth and expiration through the nose. Pressure in the pulmonary artery and left atrium or pulmonary artery wedge was measured together with thermodilution cardiac output and arterial and mixed venous oxygenation and acid-base parameters. Pulmonary vascular resistance index (PVRI), venous admixture and alveolar-arterial gradient were calculated. Nasal breathing resulted in a lower PVRI, 256 dyn s cm-5 cm-2 vs. 287 (P < 0.01). The oxygen and carbon dioxide tension and pH of arterial and mixed venous blood, venous admixture and the alveolar-arterial gradient remained unchanged. The decreased level of PVRI during nasal breathing compared to that during mouth breathing supports the notion, that endogenous nitric oxide acts as an airborne messenger to modulate the pulmonary vascular tone during normal breathing.
Normalization of human RNA-seq experiments using chimpanzee RNA as a spike-in standard (2016)

Normalization of human RNA-seq experiments employing chimpanzee RNA as a spike-in standard is reported. Human and chimpanzee RNAs exhibit single nucleotide variations (SNVs) in average 210-bp intervals. Spike-in chimpanzee RNA would behave the same as the human counterparts during the whole NGS procedures owing to the high sequence similarity. After discrimination of species origins of the NGS reads based on SNVs, the chimpanzee reads were used to read-by-read normalize biases and variations of human reads. By this approach, as many as 10,119 transcripts were simultaneously normalized for the entire NGS procedures leading to accurate and reproducible quantification of differential gene expression. In addition, incomparable data sets from different in-process degradations or from different library preparation methods were made well comparable by the normalization. Based on these results, we expect that the normalization approaches using near neighbor genomes as internal standards could be employed as a standard protocol, which will improve both accuracy and comparability of NGS results across different sample batches, laboratories and NGS platforms.
Computational imaging for 3D micrographs with 10-fold depth-of-field enhancement (2017)

Complementary kernel matching greatly increases the depth of field for time-resolved 3D ranging and snapshot imaging, and shows promise for applications ranging from biomedical microscopy to machine vision.
How teachers perceive multiageing in the middle school (2005)

Multiaged classes are thought to advance the philosophy of middle schooling through perceived benefits to social development of students and collaborative learning opportunities. However, middle schooling is a relatively new educational reform, faced with various issues of teacher resistance. A multiaged class structure was one of the eco-organisational features of middle school introduced into a single site investigation of teachers' perceptions about how these features helped or hindered their practice at one of Education Queensland's trial schools. Analysis of data indicated that teachers held a mixture of beliefs about the advantages and implementation of multiaged classes for early adolescents.
Room-temperature electroluminescence from erbium-doped porous silicon (1999)

We demonstrate stable room-temperature electroluminescence (EL) at 1.54 μm from erbium-doped porous silicon devices under both forward- and reverse-bias conditions. Erbium was infiltrated in the pores (⩽1019 cm−3) by cathodic electrochemical migration of the ions followed by high-temperature annealing (950–1100 °C) in an oxygen and nitrogen environment. The devices exhibit an exponential EL dependence in both bias conditions as a function of input power. In reverse bias, the external quantum efficiency reaches 0.01%. The EL intensity decreases by a factor of 24 for reverse bias and 2.6 for forward bias when the temperature increases from 240 to 300 K. The different device characteristics in forward and reverse biases suggest that different excitation mechanisms are responsible for EL.
The epidemiology of DSM-III-R bipolar I disorder in a general population survey (1997)

The type of bipolar disorder examined here is highly chronic, co-morbid and impairing. Increased efforts are required to attract current cases into appropriate treatment. Methodological research is needed to develop more accurate measures of other bipolar symptom profiles for use in general population epidemiological studies.
Identifying Linux bug fixing patches (2012)

In the evolution of an operating system there is a continuing tension between the need to develop and test new features, and the need to provide a stable and secure execution environment to users. A compromise, adopted by the developers of the Linux kernel, is to release new versions, including bug fixes and new features, frequently, while maintaining some older “longterm” versions. This strategy raises the problem of how to identify bug fixing patches that are submitted to the current version but should be applied to the longterm versions as well. The current approach is to rely on the individual subsystem maintainers to forward patches that seem relevant to the maintainers of the longterm kernels. The reactivity and diligence of the maintainers, however, varies, and thus many important patches could be missed by this approach. In this paper, we propose an approach that automatically identifies bug fixing patches based on the changes and commit messages recorded in code repositories. We compare our approach with the keyword-based approach for identifying bug-fixing patches used in the literature, in the context of the Linux kernel. The results show that our approach can achieve a 53.19% improvement in recall as compared to keyword-based approaches, with similar precision.
Towards a multilingual prosody model for text-to-speech (2002)

The generation of prosodic parameters such as F0 contour, duration and intensity still remains an important issue for naturally-sounding text-to-speech (TTS), although recently developed TTS systems have achieved a considerable progress. Several appropriate but language-specific rule-based, statistical or data-driven prosody models have been successfully realized in many systems. The language and parameter dependent models lead to a more complex and inefficient TTS system design. In earlier works the authors proposed a hybrid data-driven and rule-based model, which can adjust different voices or speaking styles by learning and predicting prosodic parameters. The current paper discusses the multilingual model generalization and the design of appropriate prosodic databases. Exemplary, two different languages: German and Mandarin Chinese are examined. Prediction results and perceptual evaluation with respect to F0 contours and duration values are presented. Since the perceptual results of both languages are comparable and quite satisfying, the model is qualified for the multilingual prosody control. Resynthesis stimuli obtained from modified prosodic parameters partly achieve near-to-natural mean opinion scores (MOS) above 4.0. The introduced hybrid data-driven and rule-based model is comparatively simple and enables a multilingual prosody control in TTS.