gebhart/patrepeval huggingface dataset:
ACE Inhibition But Not Angiotensin II Antagonism Reduces Plasma Fibrinogen and Insulin Resistance in Overweight Hypertensive Patients (1998)

The aim of this study was to compare the effects of the angiotensin-converting enzyme (ACE) inhibitor perindopril and the angiotensin II antagonist losartan on insulin sensitivity and plasma fibrinogen in overweight hypertensive patients. Twenty-eight overweight mild to moderate [diastolic blood pressure (DBP) >90 and <110 mm Hg] hypertensives aged 43-64 years, after a 4-week placebo period, were randomized to perindopril, 4 mg o.d., or losartan, 50 mg o.d., for 6 weeks. Then, after a new placebo period, patients were crossed to the alternative regimen for further 6 weeks. At the end of the placebo and of the treatment periods, blood pressure was measured, plasma fibrinogen was evaluated, and insulin sensitivity was assessed by the euglycemic, hyperinsulinemic clamp technique. Glucose infusion rate (GIR) during the last 30 min of clamp and total glucose requirement (TGR) were evaluated. Both perindopril and losartan reduced SBP (by a mean of 20.2 mm Hg, p < 0.001 vs. placebo; and 15.8 mm Hg, p = 0.002 vs. placebo, respectively) and DBP (by a mean of 15.2 mm Hg, p = 0.001 vs. placebo, and 11.8 mm Hg, p = 0.01 vs. placebo respectively), with no difference between the two treatments. GIR was significantly increased by perindopril (+2.91 mg/min/kg, p = 0.042 vs. placebo), but not by losartan (+0.28 mg/min/kg, NS). TGR was not modified by losartan but was increased by perindopril (+9.3 g, p = 0.042 vs. placebo). Plasma fibrinogen levels were reduced by perindopril (-53.4 mg/dl, p = 0.022 vs. placebo) but not by losartan (-16.8 mg/dl, NS). The perindopril-induced decrease in fibrinogen was correlated with the increase in GIR (r = 0.39; p < 0.01). These findings suggest that fibrinogen decrease produced by the ACE inhibitor is related to its action on insulin sensitivity, which seems to be dependent not on angiotensin II blockade but rather on other mechanisms.
Ripple formation on a nickel electrode during a glow discharge in a solution (2012)

We investigated ripple formation on a nickel electrode during a glow discharge in a solution. A nickel wire was partially melted to produce nanoparticles during glow discharge electrolysis. When the electrolysis time was over 30 min, a ripple pattern was formed on the electrode surface, and particle size increased. In this study, we investigated the relationship between the ripple formation and crystal orientation of the electrode. As a result, the ripple patterns were formed on all planes, except (111)- and (100)-oriented planes; their direction was [001].
Supplementary Table S4 from SLFN11 Negatively Regulates Noncanonical NFκB Signaling to Promote Glioblastoma Progression (2023)

&lt;p&gt;Supplementary Table S4 lists proteins that were found to bind SLFN11 after irradiation.&lt;/p&gt;
Chip-scale terahertz frequency combs through integrated intersubband polariton bleaching (2021)

Quantum cascade lasers (QCLs) represent a fascinating accomplishment of quantum engineering and enable the direct generation of terahertz (THz) frequency radiation from an electrically-biased semiconductor heterostructure. Their large spectral bandwidth, high output powers and quantum-limited linewidths have facilitated the realization of THz pulses by active mode-locking and passive generation of optical frequency combs (FCs) through intracavity four-wave-mixing, albeit over a restricted operational regime. Here, we conceive an integrated architecture for the generation of high power (10 mW) THz FCs comprising an ultrafast THz polaritonic reflector, exploiting intersubband cavity polaritons, and a broad bandwidth (2.3-3.8 THz) heterogeneous THz QCL. Quantum cascade lasers (QCLs) represent a fascinating accomplishment of quantum engineering and enable the direct generation of terahertz (THz) frequency radiation from an electrically-biased semiconductor heterostructure. By tuning the group delay dispersion in an integrated geometry, through the exploitation of light induced bleaching of the intersubband-based THz polaritons, we demonstrate spectral reshaping of the QCL emission and stable FC operation over an operational dynamic range of up to 38%, characterized by a single and narrow (down to 700 Hz) intermode beatnote. Our concept provides design guidelines for a new generation of compact, cost-effective, electrically driven chip-scale FC sources based on ultrafast polariton dynamics, paving the way towards the generation of mode locked THz micro-lasers that will strongly impact a broad range of applications in ultrafast sciences, data storage, high-speed communication and spectroscopy.
Experimental observations of breathing Kerr temporal cavity solitons at large detunings (2018)

It was recently predicted that, due to stimulated Raman scattering, temporal Kerr cavity solitons may exhibit oscillatory instabilities at large cavity detunings [Phys. Rev. Lett.120, 053902 (2018)PRLTAO0031-900710.1103/PhysRevLett.120.053902]. Here, we report experimental observations of this behavior. To access the appropriate oscillatory regime, we construct a macroscopic fiber ring resonator with a high finesse of F≈240. By synchronously driving the resonator with flat-top nanosecond pulses, we can reach very large intracavity power levels, where Raman-induced soliton oscillations can be observed. We also surprisingly find that, in the limit of large cavity driving strengths, new soliton instability regimes that are not accounted for in the known bifurcation structure of driven Kerr resonators can emerge even in the absence of Raman effects. Our experimental results are in good agreement with numerical simulations.
Synthèse et évaluation d'aminosucres, inhibiteurs de fucosidases (2003)

L'objectif de ce travail a ete de synthetiser des analogues stables du GDP-beta-L-fucose en tant qu'inhibiteurs de fucosyltransferases (agents anti-inflammatoires potentiels). Nous avons, dans un premier temps, synthetise des analogues de fucose de type aminosucre qui ont ete evalues sur l'alpha-L-fucosidase. Dans la serie la plus active, nous avons developpe une nouvelle voie de synthese d'un puissant inhibiteur de fucosidase, donnant acces a une structure de base facilement fonctionnalisable : la nitrone en serie L-lyxose synthetisee a partir du D-ribose. Des groupes chelatants, acides hydroxamiques et acides phosphoniques, ont ete greffes par cyclo-additions 1,3-dipolaires ou substitutions nucleophiles sur ce compose de base. Il reste necessaire d'inverser la position pseudo-anomerique des composes obtenus. Quelques approches sont discutees. L'activite des composes a ete evaluee sur l'alpha-L-fucosidase et l'alpha-(1,3)-fucosyltransferase de type III.
Using Key Concepts in a Translation Model for Retrieval (2015)

Many queries, especially those in the form of longer questions, contain a subset of terms representing key concepts that describe the most important part of the user's information need. Detecting the key concepts in a query can be used as the basis for more effective weighting of query terms, but in this paper, we focus on a method of using the key concepts in a translation model for query expansion and retrieval. Translation models have been used previously in community-based question answering (CQA) systems in order to bridge the semantic gap between questions and the corresponding answer documents. Our method uses the key concepts of a question as the translation context and selectively applies the translation model to the secondary (non-key) parts of the question. We evaluate the proposed method using a CQA collection and show that selectively translating key and secondary concepts can significantly improve the retrieval performance compared to a baseline that applies the translation model without considering key concepts.
Improvement of re-adhesion for commuter trains with vector control traction inverter (2002)

The authors developed a re-adhesion control algorithm for a traction inverter system with vector control for commuter train applications. The re-adhesion algorithm consists of creep control, estimated traction force control, oscillation suppression control and all wheel slip suppression control. As the result of the running tests with new control, the adhesion performance was improved by more than 20% and passenger comfort was greatly improved, regardless of the conditions of the rail, gradient and kind of rolling stock.
Silicone oil removal from a silicone intraocular lens with perfluorohexyloctane (2000)

Silicone oil can be easily dissolved in vivo from silicone intraocular lenses by perfluorohexyloctane. Using specular microscopy, we examined the corneal endothelium in a patient with silicone lens implantation immediately after cataract surgery and 5 weeks postoperatively. There were no signs of acute or chronic toxicity to the endothelium.
The stabilization and bio-functionalization of iron oxide nanoparticles using heterotelechelic polymers (2008)

Iron oxide nanoparticles (IONPs) are important tools for nanobiotechnology applications. However, aqueous instability and non-specific biodistribution problems limit the applications of IONPs. Considering this, α-phosphonic acid, ω-dithiopyridine functionalized polymers were synthesized via the reversible addition–fragmentation chain transfer (RAFT) polymerization and used for stabilizing and biofunctionalizing IONPs. A new trithiocarbonate RAFT agent bearing dimethyl phosphonate group was utilized in the synthesis of well-defined telechelic polymers of styrene, oligoethylene glycol acrylate (OEG-A) and N-isopropylacrylamide (NIPAAm). IONPs were grafted with α-phosphonic acid, ω-dithiopyridine functionalized poly(OEG-A) through the α-chain end of the polymer, as evidenced by FTIR-ATR, XPS and zeta potential measurements. Using TGA results, the grafting density of the polymer chains was calculated between 0.12 and 0.23 chains/nm2 particle depending on the molecular weight of the polymer. DLS measurements indicated that the particles grafted with poly(OEG-A) larger than 10 000 g/mol were stable in water for several days and the mean diameter of the particles was between 40 and 130 nm depending on the molecular weight of the polymer. Moreover, particles stabilized with poly(OEG-A) with a Mn = 62 000 g/mol were stable in phosphate buffer (pH 6.5, 0.1 M) containing varying concentrations of BSA. Polymer-stabilized IONPs were successfully functionalized with two different peptides, i.e. reduced glutathione as a model peptide and NGR motif as a tumor-targeting peptide through the ω-dithiopyridine functionality of the polymer, as measured by XPS and zeta potential analysis. Poly(OEG-A)-stabilized IONPs were also found to be resistant to protein adsorption.
Stereochemistry of allyl sulfones. On the structure of metalated allyl sulfones and their stereochemistry of alkylation (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereochemistry of allyl sulfones. On the structure of metalated allyl sulfones and their stereochemistry of alkylationBarry M. Trost and Norman R. SchmuffCite this: J. Am. Chem. Soc. 1985, 107, 2, 396–405Publication Date (Print):January 1, 1985Publication History Published online1 May 2002Published inissue 1 January 1985https://pubs.acs.org/doi/10.1021/ja00288a020https://doi.org/10.1021/ja00288a020research-articleACS PublicationsRequest reuse permissionsArticle Views930Altmetric-Citations85LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Genome-wide association analysis of pain severity in dysmenorrhea identifies association at chromosome 1p13.2, near the nerve growth factor locus (2016)

Dysmenorrhea is a common chronic pelvic pain syndrome affecting women of childbearing potential. Family studies suggest that genetic background influences the severity of dysmenorrhea, but genetic predisposition and molecular mechanisms underlying dysmenorrhea are not understood. In this study, we conduct the first genome-wide association study to identify genetic factors associated with dysmenorrhea pain severity. A cohort of females of European descent (n = 11,891) aged 18 to 45 years rated their average dysmenorrhea pain severity. We used a linear regression model adjusting for age and body mass index, identifying one genome-wide significant (P < 5 × 10) association (rs7523086, P = 4.1 × 10, effect size 0.1 [95% confidence interval, 0.074-0.126]). This single nucleotide polymorphism is colocalising with NGF, encoding nerve growth factor. The presence of one risk allele corresponds to a predicted 0.1-point increase in pain intensity on a 4-point ordinal pain scale. The putative effects on NGF function and/or expression remain unknown. However, genetic variation colocalises with active epigenetic marks in fat and ovary tissues, and expression levels in aorta tissue of a noncoding RNA flanking NGF correlate. Participants reporting extreme dysmenorrhea pain were more likely to report being positive for endometriosis, polycystic ovarian syndrome, depression, and other psychiatric disorders. Our results indicate that dysmenorrhea pain severity is partly genetically determined. NGF already has an established role in chronic pain disorders, and our findings suggest that NGF may be an important mediator for gynaecological/pelvic pain in the viscera.
A Distributed Resource Allocation Scheme for Self-Backhauled Full-Duplex Small Cell Networks (2021)

Full-duplex (FD) radio with wireless backhauling, is a key technology for dense small cell deployments in fifth generation (5G) cellular networks. In this paper, the problem of joint user scheduling, operation mode selection and power allocation in a two-tier cellular network with FD-capable small basestations is considered. The objective is to maximize the network sum rate under quality-of-service requirements and backhaul capacity constraints. In order to solve the problem, a distributed algorithm is developed which divides the original problem into two subproblems, viz., (i) user scheduling and mode selection; and (ii) power allocation. For the first subproblem, a low-complexity search method is proposed for opportunistically finding the best user scheduling and operation modes. In the second subproblem, an iterative successive convex approximation method is proposed to transform the nonconvex power allocation problem into a sequence of convex subproblems. The proposed solution provides a hybrid strategy which opportunistically selects FD or half-duplex (HD) operation modes for access and backhaul links. It is observed that the proposed algorithm converges in few iterations and mitigates the interferences by properly adjusting the transmission powers. Numerical results demonstrate the superiority of the proposed scheme over other possible scenarios. In particular, the proposed algorithm can achieve up to 44% gain in overall sum rate compared to a network that solely uses HD.
Optical characterization of vocal folds with optical coherence tomography (2005)

Optical coherence tomography (OCT) is a new non-invasive method to investigate biological tissue with a penetration depth of up to three millimeters. In this study OCT was used on the porcine larynx. The vocal folds were assigned to defined areas and examined by OCT followed by traditional histo-morphological analysis. We were able to validate this new method by showing that both the OCT-tomographs and the histological assays showed a clear demarcation of epithelium mucosae from the deeper layers. The current standard procedure to ensure the diagnosis, if tissue is malignant, is still an invasive one. Our results show that OCT allows the collection of crucial information about the quality of morphological changes on a vocal fold without the necessity of being invasive. Thus, we propose that optical coherence tomography should be introduced as a new and easy method for the detection of morphological changes of the vocal fold complementary to other established methods.
HVDC Connected Offshore Wind Power Plants: Review and Outlook of Current Research (2013)

This paper presents a state-of-the-art review on grid integration of large offshore wind power plants (OWPPs) using high voltage direct voltage (HVDC) for grid connection. The paper describes in detail selected challenges hereto and presents how DONG Energy Wind Power (DEWP) is addressing these challenges through three coordinated PhD projects in close collaboration with leading academia within the field. The overall goal of these projects is to acquire indepth knowledge of relevant operating phenomena in the offshore OWPP grid, rich with power electronics devices (PEDs) such as the HVDC and the PED widely used in the wind turbine generators (WTGs). Challenges hereto include PED control system interaction (from a stability point of view), assessment of the quality of vendor supplied control systems and their robustness against e.g. short circuits and load rejection. Furthermore, the outcome of the projects will be developed and validated models of e.g. the HVDC system, methodologies for assessment of control system stability and fault identification in implemented control system.
FPGA Implementation of Viterbi Algorithm for Decoding of Convolution Codes (2014)

Convolutional code is a coding scheme used in communication systems including deep space communications and wireless communications. It provides an alternative approach to block codes for transmission over a noisy channel. The block codes can be applied only for the block of data. The Convolutional coding has an advantage over the block codes in that it can be applied to a continuous data stream as well as to blocks of data. Viterbi decoder employed in digital wireless communication plays a rife role in the overall power consumption of trellis coded modulation decoder. Power reduction in Viterbi decoder could be achieved by reducing the number of states. A pre-computation architecture with T-algorithm was implemented for this purpose, and when we compare this result with full Trellis Viterbi decoder, this approach significantly reduces power consumption without degrading decoding speed. Convolutional encoding with viterbi decoding is a powerful FEC technique that is particularly suited to a channel in which the transmitted signal is corrupted mainly by Additive White Gaussian Noise (AWGN). It operates on data stream and has memory that uses previous bits to encode. The Viterbi Algorithm (VA) is proposed, used for decoding a bit stream that has been encoded using FEC code. The Convolutional encoder adds redundancy to a continuous stream of input data by using a linear shift register. A pre-computation architecture with Viterbi algorithm is implemented for this purpose, Viterbi (Convolutional) encoder and Viterbi decoder are designed and implemented using FPGA technology, which are the essential blocks in digital communication systems. It is particularly suited to a channel in which the transmitted signal is corrupted mainly by AWGN. The Viterbi decoder of Constraint length 7 and code rate is considered. The design is implemented using verilog on Xilinx Spartan 3E and advanced Spartan 6 board and the results and Comparisons are presented.
Session-Oriented Communication System for truly reliable and robust Smart Grid (2011)

Environmental sustainability issues and the costs of new power generation and transmission have increased the interest in evolving current power grid to new technologies. The Smart Grid is a promising technology, since it allows a distributed computing approach with potentials for self-diagnosing/-healing, reliable multi-user communication and fast hard real-time control. However, the missing standardization associated with heterogeneity of legacy systems and wide-area service demands, makes very challenging to adopt Smart Grid in a cost-effective way. By considering this, we propose the Session-Oriented Communication System (SOCSys) to overcome the above issues by enhancing Smart Grid with truly reliable and robust capabilities over heterogeneous environments. SOCSys achieves this goal by orchestrating session-control with innovative network-centric facilities operating over a wireless mesh Information Network compliant with IEEE 802.11e/s standard. The simulation results show that SOCSys improved network performance in terms of bandwidth utilization and minimization of delay, while consuming low network resources. Graphical analyses showed that SOCSys supported multimedia sessions with excellent quality, where it outperforms the experiments with regular settings.
Adsorption of H2O, CO2 and Xe on Soft Surfaces (2008)

The interactions of water, carbon dioxide, and Xe with octadecanethiol (C(18)H(37)SH, ODT) self-assembled monolayers (SAMs) were studied under ultrahigh vacuum conditions employing temperature-programmed desorption and optical diffraction measurements. The ODT layer was grown on a 1 nm thick gold film deposited over a Ru(001) single-crystal substrate. The gases used in this report differ in their lateral interactions while adsorbed on ODT-SAM being either repulsive (Xe) or attractive (H(2)O, CO(2)). The activation energies for desorption of the first layer from ODT are E(a) = 3.6 +/- 0.9, 4.1 +/- 0.5, and 8.5 +/- 0.9 kcal/mol for Xe, CO(2), and H(2)O, respectively. Sticking probabilities of the three gases on the soft ODT surface are S(0) = 0.7 +/- 0.1, 0.8 +/- 0.1, and 0.95 +/- 0.05 for xenon, CO(2), and water, respectively, derived from the respective adsorption curves. Optical diffraction studies from multilayer coverage grating of Xe on ODT-SAM have demonstrated that sublimation is a thermodynamically more favorable process over diffusion and wetting. The significantly lower binding energy of the first layers of H(2)O and CO(2) adsorbed on the soft surface of ODT compared to that on clean metals and oxides, reflects generally weak (CO(2)) and hydrophobic (H(2)O) interactions that are important for understanding the behavior of these molecules on interfaces that are found in biological systems.