gebhart/patrepeval huggingface dataset:
The T-body approach combining antibody specificity with T cell activity for adoptive vaccination of cancer (2013)

T “T-body” approach is based on engineered T cells expressing chimeric antibody receptor (CAR) that endows them with antibody-type specificity to any pre-defined target antigen. We have designed the modular CAR construct so that the modified, redirected T cells will undergo activation and perform their effector or regulatory function upon encountering their target. Accordingly, the CAR’s composition includes extracellular recognition domain made of a single chain variable fragment (scFv) of an antibody linked to intracellular domains of various stimulatory and co-stimulatory molecules that dictate the function of the transduced cells. For antitumor reactivity we constructed CARs made of scFv specific to human Her2/neu, CEA and CD24 (a cancer stem cell marker of certain adenocarcinomas such as pancreatic and colorectal ones). To optimize the antitumor effect in therapeutic settings we have treated either immunodeficient mice bearing human cancer xenografts or transgenic mice that spontaneously develop tumors expressing TAA. T-bodies effectively rejected primary as well as disseminated tumors. Multiple systemic administrations of T-bodies were required for complete elimination of xenografts and autologous murine tumors. Of note, single intratumoral injection was sufficient to eliminate breast, prostate cancer bone metastases as well as colorectal and pancreatic cancers. Moreover, under certain conditions, we have established a time-window which allows allogeneic T-bodies to serve as universal donors. Recently, our pioneering studies in murine models have been reproduced and applied in pilot trials to end-stage cancer patients. Dramatic complete responses have been already reported in neuroglioma, chronic lymphocyte leukemia, and acute child and adult B cell lymphoma patients. These trials have also reported on several treatment-related severe yet manageable side effects (mostly associated with acute ‘cytokine-storm’ and ‘tumor lysis’ syndrome, both outcomes of the vigorous antitumor responses of the T-bodies that could eliminate a huge tumor mass within the first few weeks treatment. The dynamics of the T-body antitumor effect reflect both their built-in ability to specifically recognize the tumor, propagate and reject it and further differentiate into memory cells that keep the tumor on-check.
Causality of surface plasmon polariton emission processes (2006)

Fundamental physical quantum phenomena, such as surface plasmon polaritons (SPP's), require specific conditions as described in their dispersion relation for excitation by photons. These conditions exactly define the $\mathbf{k}$ vector of the incident photons as well as the elastically reemitted, outbound photons that follow from the decay of the plasmon. Our conclusion demonstrates that these requisites are indeed fulfilled even on the introduction of an inelastic, wavelength-shifting process like fluorescence emission to the system. Such a process is established by placing fluorescent molecules into the strong evanescent field of the SPP. The analysis of the outbound photons shows an angular behavior, which can only be explained if the fluorescent photons also satisfy SPP conditions. This behavior enables the development of a model for the chronology and causality of surface plasmon polariton deexcitation mechanisms.
Radiation Forces and Momenta in Dielectric Media (1973)

There has existed a continuing dialogue concerning the proper identification of radiation forces and momenta in dielectric media. I argue herein that a sensible and consistent picture of these forces and momenta is available. That is, the density of electromagnetic momentum $\stackrel{\ensuremath{\rightarrow}}{\mathbf{G}}$ is given by $\stackrel{\ensuremath{\rightarrow}}{\mathbf{G}}=\frac{\stackrel{\ensuremath{\rightarrow}}{\mathbf{S}}}{{c}^{2}}$, where $\stackrel{\ensuremath{\rightarrow}}{\mathbf{S}}$ is Poynting's vector. The forces which are exerted on material objects in dielectric media are associated with changes in both the electromagnetic and mechanical momenta of the media. In fairly broad circumstances, such forces may be found from the rate of change in a pseudomomentum $\stackrel{\ensuremath{\rightarrow}}{\mathbf{K}}$ given by $\stackrel{\ensuremath{\rightarrow}}{\mathbf{K}}=\ensuremath{\epsilon}\stackrel{\ensuremath{\rightarrow}}{\mathbf{G}}$, where $\ensuremath{\epsilon}$ is the dielectric constant of the medium.
Influence of new hire transition workload on insomnia in nurses (2018)

To mitigate the risk of insomnia, we suggest that additional support should be provided to non-new nurses to assist them in the new hire transition.
Ocean Bottom Seismometer Augmentation in the North Pacific (OBSANP) - cruise report (2014)

The Ocean Bottom Seismometer Augmentation in the North Pacific Experiment (OBSANP,&#13;\nJune-July, 2013, R/V Melville) addresses the coherence and depth dependence of deep-water&#13;\nambient noise and signals. During the 2004 NPAL Experiment in the North Pacific Ocean, in&#13;\naddition to predicted ocean acoustic arrivals and deep shadow zone arrivals, we observed "deep&#13;\nseafloor arrivals" (DSFA) that were dominant on the seafloor Ocean Bottom Seismometer (OBS)&#13;\n(at about 5000m depth) but were absent or very weak on the Distributed Vertical Line Array&#13;\n(DVLA) (above 4250m depth). At least a subset of these arrivals correspond to bottomdiffracted&#13;\nsurface-reflected (BDSR) paths from an out-of-plane seamount. BDSR arrivals are&#13;\npresent throughout the water column, but at depths above the conjugate depth are obscured by&#13;\nambient noise and PE predicted arrivals. On the 2004 NPAL/LOAPEX experiment BDSR paths&#13;\nyielded the largest amplitude seafloor arrivals for ranges from 500 to 3200km. The OBSANP&#13;\nexperiment tests the hypothesis that BDSR paths contribute to the arrival structure on the deep&#13;\nseafloor even at short ranges (from near zero to 4-1/2CZ). The OBSANP cruise had three major&#13;\nresearch goals: a) identification and analysis of DSFA and BDSR arrivals occurring at short&#13;\n(1/2CZ) ranges in the 50 to 400Hz band, b) analysis of deep sea ambient noise in the band 0.03&#13;\nto 80Hz, and c) analysis of the frequency dependence of BR and SRBR paths. On OBSANP we&#13;\ndeployed a 32 element VLA from 12 to 1000m above the seafloor, eight short-period OBSs and&#13;\nfour long-period OBSs and carried out a 15day transmission program using a J15-3 acoustic&#13;\nsource.
Research on the algorithm of gravity aided Inertial Navigation based on CKF (2014)

Using the information of gravity filed for aided inertial navigation can ensure the system's passive resistance and anti-jamming, and has become the hot topic of integrated navigation field. In this paper, we establish state-space model derived from the error equation of Inertial Navigation System (INS), and set the difference between indicated gravity anomaly and measured gravity anomaly which contains the information of position error as the measurement. After that, Cubature Kalman Filter (CKF) is introduced for estimation of navigation error online, which avoids the linearization of measurement. At last, the simulation system is realized based on the DNSC08 gravity model to inspect and verify the algorithm. The simulation results show that, the algorithm based on CKF for gravity aided navigation can strength the system's performance effectively.
Structural Characterization of PEGylated Hexaphenylalanine Nanostructures Exhibiting Green Photoluminescence Emission (2017)

Peptides containing aromatic residues are known to exhibit spontaneous phenomena of supramolecular organization into ordered nanostructures (NSs). In this work we studied the structural behavior and optoelectronic properties of new biocompatible materials obtained by the self-assembly of a series of hexaphenylalanines (F6) modified at the N terminus by a PEG chain of different lengths. PEG<sub>12</sub> -F6, PEG<sub>18</sub> -F6, and PEG<sub>24</sub> -F6 peptides were synthesized by coupling sequentially two, three, or four units of amino-carboxy-PEG<sub>6</sub> blocks, each one containing six oxyethylene repetitions. Changes in the length and composition of the PEG chain were found to modulate the structural organization of the phenylalanine-based nanostructures. An increase in the self-aggregation tendency was observed with longer PEG chains, whereas, independently of the PEG length, the peptide NSs display cross-β-like secondary structures with an antiparallel β-strand arrangement. WAXS/GIWAXS diffraction patterns indicate a progressive decrease in fiber order along the series. All the PEG-F6 derivatives present blue photoluminescent (PL) emission at 460 nm, with the adduct with the longest PEG chain (PEG<sub>24</sub> -F6) showing an additional green emission at 530 nm.
Modular type-based reverse engineering of parameterized types in Java code (1999)

An analysis is provided for Java programs that reverse engineers parameterized types into existing Java code. This analysis propagates precise type information about the contents of container objects. As an application, the analysis can be used to justify the safe removal of downcasts that are guaranteed to succeed. Another application is in automatically reverse engineering parameterized types into existing Java libraries, so that they can be used in Java dialects with parameterized types.
Viral Mutation Rates (2010)

Accurate estimates of virus mutation rates are important to understand the evolution of the viruses and to combat them. However, methods of estimation are varied and often complex. Here, we critically review over 40 original studies and establish criteria to facilitate comparative analyses. The mutation rates of 23 viruses are presented as substitutions per nucleotide per cell infection (s/n/c) and corrected for selection bias where necessary, using a new statistical method. The resulting rates range from 10(-8) to 10(-6) s/n/c for DNA viruses and from 10(-6) to 10(-4) s/n/c for RNA viruses. Similar to what has been shown previously for DNA viruses, there appears to be a negative correlation between mutation rate and genome size among RNA viruses, but this result requires further experimental testing. Contrary to some suggestions, the mutation rate of retroviruses is not lower than that of other RNA viruses. We also show that nucleotide substitutions are on average four times more common than insertions/deletions (indels). Finally, we provide estimates of the mutation rate per nucleotide per strand copying, which tends to be lower than that per cell infection because some viruses undergo several rounds of copying per cell, particularly double-stranded DNA viruses. A regularly updated virus mutation rate data set will be available at www.uv.es/rsanjuan/virmut.
First case of trastuzumab emtansine-associated hemorrhagic telangiectasias treated with propranolol (2018)

International audience
Functional Assessment of Outer and Middle Macular Layers in Multiple Sclerosis (2020)

The involvement of macular function in its preganglionic elements, during the neurodegenerative process of multiple sclerosis (MS), is controversial. In this case-control observational and retrospective study, we assessed multifocal electroretinogram (mfERG) responses from 41 healthy Controls, 41 relapsing-remitting MS patients without optic neuritis (ON) (MS-noON Group), 47 MS patients with ON: 27 with full recovery of high-contrast best corrected visual acuity (BCVA) (MS-ON-G Group) and 20 with poor recovery of BCVA (MS-ON-P Group). MfERG N1 and P1 implicit times (ITs), and N1-P1 response amplitude densities (RADs) were measured from concentric rings (R) with increasing foveal eccentricity: 0-5&amp;deg; (R1), 5-10&amp;deg; (R2), 10-15&amp;deg; (R3), 15-20&amp;deg; (R4), 20- 25&amp;deg; (R5), and from retinal sectors [superior, nasal, inferior and temporal] between 0-15&amp;deg; and 0- 25&amp;deg;. In MS-ON-P Group, mean mfERG RADs detected from R1 (0-5&amp;deg;) and from the central nasal quadrant (0-15&amp;deg;) were significantly reduced (p&amp;lt;0.01) with respect to those of Control, MS-noON and MS-ON-G Groups. No other significant differences between Groups for any mfERG parameters were found. Our results suggest that in MS, exclusively after ON with poor recovery of BCVA, the neurodegenerative process can induce dysfunctional mechanisms involving photoreceptors and bipolar cells of the fovea and of the more central nasal macular area.
Advanced Mobile Phone Service: Voice and Data Transmission (1979)

Use of the amps (Advanced Mobile Phone Service) microwave channel, operating in the 800- to 900-MHz band, creates unique problems in addition to those connected with conventional land communications. Because the channel characteristics are not fixed, they present design challenges and impairments that must be dealt with to protect mobile telephone users from experiencing excessive variabilities in voice transmission quality and in control and signaling reliability. This paper describes the radio transmission features of the amps system, emphasizing the processing and control techniques designed to deal with the dynamic nature of the mobile radio channel.
Epigenetic Inactivation of a Cluster of Genes Flanking MLH1 in Microsatellite-Unstable Colorectal Cancer (2007)

Biallelic promoter methylation and transcriptional silencing of the MLH1 gene occurs in the majority of sporadic colorectal cancers exhibiting microsatellite instability due to defective DNA mismatch repair. Long-range epigenetic silencing of contiguous genes has been found on chromosome 2q14 in colorectal cancer. We hypothesized that epigenetic silencing of MLH1 could occur on a regional scale affecting additional genes within 3p22, rather than as a focal event. We studied the levels of CpG island methylation and expression of multiple contiguous genes across a 4 Mb segment of 3p22 including MLH1 in microsatellite-unstable and -stable cancers, and their paired normal colonic mucosa. We found concordant CpG island hypermethylation, H3-K9 dimethylation and transcriptional silencing of MLH1 and multiple flanking genes spanning up to 2.4 Mb in microsatellite-unstable colorectal cancers. This region was interspersed with unmethylated genes, which were also transcriptionally repressed. Expression of both methylated and unmethylated genes was reactivated by methyltransferase and histone deacetylase inhibitors in a microsatellite-unstable colorectal carcinoma cell line. Two genes at the telomeric end of the region were also hypermethylated in microsatellite-stable cancers, adenomas, and at low levels in normal colonic mucosa from older individuals. Thus, the cluster of genes flanking MLH1 that was specifically methylated in the microsatellite-unstable group of cancers extended across 1.1 Mb. Our results show that coordinate epigenetic silencing extends across a large chromosomal region encompassing MLH1 in microsatellite-unstable colorectal cancers. Simultaneous epigenetic silencing of this cluster of 3p22 genes may contribute to the development or progression of this type of cancer.
Modern Cheating Techniques, Their Adverse Effects on Engineering Education and Preventions (2014)

Cheating is an immoral way of achieving higher grades in school by breaking rules and regulations and gaining an unfair advantage in a competitive environment. This dishonest behavior is becoming a more serious issue, particularly with all the technological developments, and it considerably threatens the educational systems in engineering, science, fine arts, law, nursing, medicine and pharmacy. Approximately 70% of school students in the U.S. admitted that they were involved in direct and/or indirect cheating actions during exams, homework, term projects, reports, papers and presentations using a variety of cheating techniques. These techniques include all kinds of cell phones, camera phones, earphones, MP3 players, graphing calculators, iPads, texting devices, monitoring devices, multifunctional watches, etc. Similar trends have been observed in many other developed or developing countries worldwide. These issues are more crucial for online courses, which have been gaining popularity for full-time employees who wish to further their education. In the present study, we have evaluated many of the high-tech cheating systems and devices that have been a major threat to engineering education, and we have reported the possible ways for improperly using these items in colleges. This study offers many opportunities for faculty members, teachers, lecturers and family members to become aware of the problem, take action, prevent such incidences and increase the quality of engineering education.
Biologie du virus de l’hépatite B (1998)

Des 1885, Lurman rapportait des cas de jaunisse faisant suite a des vaccinations contre la variole. Toutefois, la notion d’hepatite consecutive a la transmission parenterale de serum humain n’a ete totalement etablie qu’au cours des annees 30 avec, notamment, les travaux de Mac Callum qui montrerent que les jaunisses consecutives a des vaccinations contre la fievre jaune etaient liees a l’addition de serum humain utilise pour stabiliser la preparation vaccinale. Mac Callum remarqua aussi que la frequence des hepatites dues a la reutilisation de seringues etait plus importante quand elles avaient ete simplement lavees plutot que sterilisees. Par ailleurs, il fut observe que l’incubation de ce type de jaunisse etait plus longue que celle de l’hepatite epidemique de transmission feco-orale. En 1953, l’Organisation mondiale de la sante (OMS) adoptait la terminologie d’hepatites A et B que Mac Callum avait proposee en 1947 [1]. En 1963, Blumberg decouvrait dans le serum d’un aborigene australien un antigene (l’antigene Australia) reagissant avec le serum d’un hemophile americain. Le lien entre cet antigene Australia (denomme actuellement AgHBs) et l’hepatite B fut ensuite etabli par differents chercheurs [2, 3]. Un pas decisif etait alors franchi, offrant aux chercheurs un premier outil qui a permis par la suite d’identifier l’agent etiologique de l’hepatite B, de faire un diagnostic serologique de la maladie et d’entreprendre des etudes epidemiologiques. D’autres systemes antigeniques (AgHBc, AgHBe) furent ensuite mis en evidence, amenant le developpement, dans les annees 70 et 80, de tests serologiques radio-immunologiques puis immuno-enzymatiques permettant la detection de ces differents antigenes et/ou des anticorps correspondants (anti-HBs, anti-HBc, anti-HBe). Une fois etabli le caractere neutralisant des anti-HBs, l’idee d’un vaccin produit par purification de l’AgHBs plasmatique vit le jour au debut des annees 70 et, en 1975, une equipe tourangelle dirigee par P. Maupas entreprenait les premiers essais de vaccination chez l’homme [4]. Les deux dernieres decennies furent marquees par les progres de la biologie moleculaire qui ont permis une analyse du genome du virus de l’hepatite B (VHB), amenant une meilleure connaissance de la biologie de ce virus et ouvrant la voie a la mise au point de vaccins produits par recombinaison genetique.
Optimization of Silicon Nitride Y-Branch Optical Waveguide for Evanescent Field Biosensor (2014)

Evanescent field had been widely used in bio and chemical sensors. However in most cases, evanescent field is not maximized and thus the performance of the sensor is not optimized. It is the aim of the paper to optimize the design of 1:2 Y-branch splitter optical waveguide through simulation by using FD-BPM. Y-branch splitter without taper are simulated to optimize the power loss. Width of waveguide and effective angle are manipulated in the power loss optimization. The result shows that evanescent field is maximized at optimized thickness and width. The result suggests that Y-branch splitter with width of 25μm, effective angle of 6.24° is the best design for evanescent field sensor application with both high sensitivity and signal to noise ratio.
Energía solar térmica para el confort de los hogares españoles (2005)

El consumo de energia en los hogares de la Union Europea representa el 40% del consumo total. La mayor parte es originado por la produccion de agua caliente sanitaria y climatizacion:
calefaccion, aire acondicionado y ventilacion. El resto es el consumo electrico en iluminacion y en los electrodomesticos. La reduccion de este consumo se incluye en los programas de ahorro comprometidos en la firma de los acuerdos de Montreal y de Kyoto.
Erratum: “High efficiency GaN-based light-emitting diodes fabricated on dielectric-mask-embedded structures” [Appl. Phys. Lett. 95, 011108 (2009)] (2009)

First Page
Tangible jukebox (2010)

Since commercial musical recordings became available about a century ago and until very recently, they had always been distributed by means of a physical support. Nowadays that record companies have ultimately started to distribute over the Internet, music does not use physical space anymore, and we can now store amazingly large collection in our computers or portable players. But this etherealness does not come without some drawbacks, such as browsing by the covers or organizing and grouping elements or collections.In this paper we propose a system in which files (intangible) become physical objects again, thus recovering part of the mysticism related with vinyls or compact discs, without loosing most of the benefits inherent to digital data, and applying at the same time some advantages that tangible and tabletop interfaces can offer. Complementarily, and from a more agnostic perspective, this paper also starts to explore on the tangible manipulation of sets or collections of items.
Construction of a Soft X-Ray Emission Spectroscopy (SXES) Apparatus and Its Application for Study of Electronic and Atomic Structures of a Multilayer System (1990)

A soft X-ray emission spectroscopy (SXES) apparatus was constructed using a grating monochromator. The resolution was sufficient to show differences in valence electronic structures of Si compounds including pure Si crystal. A nondestructive analysis of a Ni/Si(111) specimen with heat treatment was carried out using either a clear difference in Si L 2,3 SXES spectra of Ni silicide and Si single crystals or the fact that the soft X-ray production depth increases in a solid with increasing energy of a primary electron, E p . The electronic and atomic structures of the surface and interface of specimens adopted were clarified with E p varying between 1.5 and 10 keV.
Partial gene duplication in Duchenne and Becker muscular dystrophies. (1988)

Duchenne and Becker muscular dystrophies (DMD and BMD) are progressive muscle wasting disorders with an X linked recessive mode of inheritance. We have surveyed 120 unrelated patients with DMD or BMD for gene duplications using a series of genomic probes from within the DMD/BMD gene locus. In three patients, two with DMD and one with BMD, a duplicated region within the DMD/BMD locus has been shown by Southern blot analysis and transmission densitometry. In two cases a new restriction fragment spanning the duplication junction has been visualised, indicating that the duplications are tandemly arranged. Mendelian inheritance of the duplication has been shown in two families by following the segregation of the duplication junction fragment. The three duplication cases have been analysed with a cDNA probe isolated from the DXS206 region of the DMD/BMD locus and the duplication of a specific set of exons has been found in two cases. This study shows that all three duplications are internal to the gene and confirms that such a duplication can result in a genetic disorder through the disruption of exon organisation.