gebhart/patrepeval huggingface dataset:
Abstract 4733: Dysregulation of CUL4A and CUL4B ubiquitin ligases in lung cancer (2017)

Abstract Background: The Cullin-RING ubiquitin ligases 4 (CRL4) is implicated in controlling cell cycle, DNA damage repair and checkpoint response based on studies employing cell lines and mouse models. CRL4 proteins, including CUL4A and CUL4B are often highly accumulated in human malignancies. Elevated CRL4 attenuates DNA damage repair and increases genome instability that is believed to facilitate tumorigenesis. However, this has yet to be evaluated in human cancer patients. Methods: 352 lung cancer and 62 benign lung specimens of Asian origin were constructed into tissue microarrays (TMAs) of four distinct lung cancer subtypes. Expression of CUL4A, CUL4B and their substrates was detected by immunohistochemistry (IHC), and analyzed statistically for their prognostic value and association with DNA damage response and genomic instability. Results: Both CUL4A and CUL4B are overexpressed in the majority of lung carcinomas (PCUL4A&amp;lt;0.001, PCUL4B&amp;lt;0.001), and significantly associated with tumor size (PCUL4A&amp;lt;0.001, PCUL4B=0.002), lymphatic invasion (PCUL4A=0.004, PCUL4B&amp;lt;0.001), metastasis (PCUL4A=0.019, PCUL4B=0.006), and advanced TNM stage (PCUL4A&amp;lt;0.001, PCUL4B&amp;lt;0.001), which parallels gene amplification and abnormal activation of the canonical Wnt signaling. Moreover, overexpression of CUL4A, but not CUL4B, is significantly associated with tobacco smoking (P=0.01), and inversely correlated with XPC and p21, both of which are substrates of CUL4A (PCUL4A=0.019, PCUL4B=0.006). Higher levels of CUL4A or CUL4B are significantly associated with patients’ OS (PCUL4A&amp;lt;0.001, PCUL4B&amp;lt;0.001) and PFS (PCUL4A&amp;lt;0.001, PCUL4B=0.001). Conclusion: Our findings revealed that CUL4A and CUL4B are differentially associated with etiological factors for pulmonary malignancies and are independent prognostic markers for survival of distinct lung cancer subtypes. Citation Format: Hui Li, Lei Jia, Fan Yan, Pengbo Zhou. Dysregulation of CUL4A and CUL4B ubiquitin ligases in lung cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 4733. doi:10.1158/1538-7445.AM2017-4733
Enhanced Photocatalytic Removal of Methylene Blue From Seawater Under Natural Sunlight Using Carbon-Modified n-TiO2 Nanoparticles (2013)

In this study, photocatalytic removal of methylene blue (MB) from natural seawater was examined using carbon-modified titanium oxide (CM-n-TiO2) nanoparticles under illumination of real sunlight. CM-n-TiO2 nanoparticles exhibited significantly higher photocatalytic degradation efficiency compared to unmodified n-TiO2. Photocatalytic removal studies were carried out at different initial dye concentrations (5-30 µM), catalyst dose (0.5-1.5 gL-1), and pH (3-9). The highest removal rate of MB was obtained at the optimal conditions of pH 8 and 1.0 gL-1 of CM-n-TiO2. The solar photocatalytic removal of MB from seawater using CM-n-TiO2 obeyed a pseudo-first order kinetics according to the Langmuir-Hinshelwood model.
In vivo diagnosis of cervical intraepithelial neoplasia using 337-nm-excited laser-induced fluorescence. (1994)

Laser-induced fluorescence at 337-nm excitation was used in vivo to differentiate neoplastic [cervical intraepithelial neoplasia (CIN)], nonneoplastic abnormal (inflammation and human papilloma viral infection), and normal cervical tissues. A colposcope (low-magnification microscope used to view the cervix with reflected light) was used to identify 66 normal and 49 abnormal (5 inflammation, 21 human papilloma virus infection, and 23 CIN) sites on the cervix in 28 patients. These sites were then interrogated spectroscopically. A two-stage algorithm was developed to diagnose CIN. The first stage differentiated histologically abnormal tissues from colposcopically normal tissues with a sensitivity, specificity, and positive predictive value of 92%, 90%, and 88%, respectively. The second stage differentiated preneoplastic and neoplastic tissues from nonneoplastic abnormal tissues with a sensitivity, specificity, and positive predictive value of 87%, 73%, and 74%, respectively. Spectroscopic differences were consistent with a decrease in the absolute contribution of collagen fluorescence, an increase in the absolute contribution of oxyhemoglobin attenuation, and an increase in the relative contribution of reduced nicotinamide dinucleotide phosphate [NAD(P)H] fluorescence as tissue progresses from normal to abnormal in the same patient. These results suggest that in vivo fluorescence spectroscopy of the cervix can be used to diagnose CIN at colposcopy.
Recent advances in applications of nanoparticles as enzyme mimetics (2015)

In additional to unique optical, electrical and magnetic characteristics, nanomaterials possess efficient enzyme-like catalytic activitives: peroxidase-like, superoxide dismutase-like, catalase-like, oxidase-like, uricase-like, nitrate reductase-like, and so on. Nanoparticles as enzyme mimetics (nanozymes) show several advantages over natural enzymes, such as facile production, easy to store and transportation, stable and reusable, various administration routes. The latest research progresses in environmental protection, food safety and biomedical applications of nanozymes are reviewed. Moreover, the prospects and possible obstacles in application of nanozymes are discussed.
A phase II trial on the combination of bevacizumab and irinotecan in recurrent ovarian cancer. (2014)

5564 Background: Irinotecan and bevacizumab have single agent activity in both platinum sensitive and resistant recurrent ovarian cancer. We sought to evaluate the efficacy and safety of the combination in this setting. The primary endpoint is to estimate the progression free survival (PFS) at 6 months. Secondary objectives include overall survival (OS), observed response rate (ORR), duration of response, and toxicity. Methods: Ovarian cancer patients with recurrence after any number of prior regimens were eligible. Irinotecan 250 mg/m2 (amended to 175 mg/m2 after treatment-related toxicities in the first 6 patients) and bevacizumab 15 mg/kg were administered every 3 weeks until disease progression or toxicity. Response was assessed by RECIST every 2 cycles and by CA-125 criteria for those without measurable disease. Results: Of the 29 patients enrolled, 10 were platinum-sensitive and 19 were platinum-resistant. The median number of prior regimens was 5 (range 1-12): 13 patients had prior bevacizumab and 11 patients prior topotecan. The median number of study cycles given was 7 (range 1-34); 5 patients withdrew after 1 cycle (3 due to toxicity). Of the 24 patients assessable for response, 8 patients experienced partial response (PR), 13 maintained stable disease (SD), and 3 had progressive disease; 12 patients with PR/SD were platinum resistant. The ORR was 27.6% (95% CI: 0.127-0.472) and the clinical benefit rate was 72.4% (95% CI: 0.565-0.873) for the intention-to-treat population (n=29). Twelve patients had longer than 6 months of sustained response. Median PFS was 8.1 months (95% CI: 5.1-12.3 months); median OS was 15.9 months (95% CI: 13.4 months- upper bound not reached). The PFS rate at 6 months was 55.2% (95% CI: 0.397-0.766). The most common grade 3/4 toxicities included diarrhea (5 pts), neutropenia (3), hypertension (3), proteinuria (2), fatigue (2), nausea (2), abdominal pain (2), and GI perforation (1). No treatment-related deaths were observed. Conclusions: The combination of irinotecan and bevacizumab showed encouraging activity in heavily-pretreated patients with recurrent ovarian cancer. The median PFS of 8.1 months is comparable to other bevacizumab-containing doublets reported in the AURELIA trial. Clinical trial information: NCT01091259.
Tunable emission in poly(4-vinylpyridine)-based gel (1998)

We have discovered a new class of smart-gels, poly(4-vinylpyridine) (PVPy) swollen with pyridine (Py), that following photoexcitation (395, 455, 557 nm) emits three independent colors: blue, green, and red (477, 527, 585 nm, respectively). These excitation wavelengths also induced large reversible changes in pH and electrical conductivity. The primary photoexcitation paths within this photo-active gel are singlet-excitons. The origin of this phenomenon is attributed to the combined properties of weak coupling via hydrogen-bonding and high polarizability. Our preliminary model suggests, that C—H ⃛N based Py associates are formed during the gelation process. Photoexcitation leads to proton transfer within three different kinds of assemblies and to a solid-state-like electronic behavior of the gel. This system, i. e. a photoconducting transparent organic gel with multiple color emission, is very attractive for a wide range of promising applications in the field of optoelectronic devices such as organic LED's and 3D holography.
Power Scaling of CW Crystalline OPOs and Raman Lasers (2021)

Optical parametric oscillators (OPOs) and Raman lasers are two nonlinear-based laser technologies that extend the spectral range of conventional inversion lasers. Power and brightness scaling of lasers are significant for many applications in industry, medicine, and defense. Considerable advances have been made to enhance the power and brightness of inversion lasers. However, research around the power scaling of nonlinear lasers is lacking. This paper reviews the development and progress of output power of continuous-wave (CW) crystalline OPOs and Raman lasers. We further evaluate the power scalability of these two laser technologies by analyzing the cavity architectures and gain materials used in these lasers. This paper also discusses why diamond Raman lasers (DRLs) show tremendous potential as a single laser source for generating exceedingly high output powers and high brightness.
Impact of Network Densification on the Performance of a Non-Public URLLC Factory Network (2021)

Densification of the network deployment, for example by adding new sectors or sites within an existing mobile communication network, has traditionally been an efficient way to improve the system coverage and capacity. That will be the case even for the ultra-reliable low-latency communication (URLLC) services, but the overall situation and the feasibility of the different deployment options will depend on the characteristics of the URLLC service in question. URLLC services with relaxed latency requirements, allowing multiple transmission attempts, can tolerate a decent level of inter-cell interference while still being able to guarantee the desired quality-of-service for all users, which makes it possible to improve the URLLC service capacity by adding new gNodeBs with omnidirectional or directional antennas. However, when the URLLC services require extremely low latency that do not allow for retransmissions, the system performance becomes quite sensitive to the inter-cell interference, which means that in practice the gNodeBs should be equipped with beamformed antennas to reach high levels of URLLC service capacity. Finally, an active distributed antenna system could be an efficient way to secure good coverage throughout the desired service area.
Molecular Characterization of 8-Methoxyfluoroquinolone Resistance in a Clinical Isolate of Methicillin-Resistant <i>Staphylococcus aureus</i> (2007)

GyrA and GrlA mutations mainly conferred to 8-methoxyfluoroquinolone resistance in this isolate.
Abstract 3861: Downregulation of protein phosphatase 2A promotes prostate cancer progression and metastasis. (2013)

Abstract Clinical progression of prostate cancer (PCa) is characterized by a transition from castration-sensitive (CS) to castration-resistant (CR) phenotype. The resulting CR tumors are highly aggressive and metastatic, and thus pose increased risk of morbidity and death to PCa patients. Therefore, identification of novel gene targets associated with CR growth and metastatic behavior remain a priority area in PCa research. Previously, we identified that PPP2CA, which encodes for the α–isoform of catalytic subunit of PP2A (a serine/threonine phosphatase), is downregulated in CRPCa. In additional findings, we reported that PP2A downregulation sustained the growth of PCa cells under steroid–deprived conditions. In the present study, we examined the role of PP2A in malignant behavior of PCa cells using in vitro and in vivo functional assays. Furthermore, we also delineated the underlying molecular mechanisms. Our data demonstrated that downregulation of PPP2CA (in CS LNCaP cells) promoted, whereas its overexpression (in CR C4-2 and PC3 cells) decreased the migration and invasion of human PCa cells. Similarly, we observed a loss of homotypic interactions in PPP2CA-silenced LNCaP cells, while it increased in PPP2CA-overexpressing C4-2 and PC3 cells. These changes were associated with epithelial to mesenchymal transition (EMT) or vice versa in PPP2CA-silenced or overexpressing PCa cells, respectively. When examined in vivo in an orthotopic mouse model, PPP2CA-overexpressing PC3 cells exhibited dramatic decrease in tumorigenesis due to diminished proliferation and enhanced apoptosis as compared to the control cells. Moreover, significant reduction in metastatic incidence was also observed. Mechanistic studies revealed that PPP2CA downregulation increases nuclear accumulation of β-catenin and NF-κB and subsequent activation of transcriptional activity of the responsive gene promoters. We also observed cooperative involvement of both β-catenin and NF-κB in the PPP2CA downregulation-induced EMT and invasiveness of PCa cells. Lastly, our data demonstrated a role of PP2A/Akt axis in enhanced nuclear accumulation of β-catenin and NF-κB through phosphorylation-induced inactivation of Gsk3-β and IkB-α, respectively. Altogether, our data suggest that loss of PPP2CA is associated with PCa progression and metastasis, and restoration of PP2A activity could serve as an effective preventive and/or therapeutic approach against the advanced disease. Citation Format: Arun Bhardwaj, Seema Singh, Sanjeev K. Srivastava, Sumit Arora, Stephen J. Hyde, Richard E. Honkanen, William E. Grizzle, Ajay P. Singh. Downregulation of protein phosphatase 2A promotes prostate cancer progression and metastasis. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3861. doi:10.1158/1538-7445.AM2013-3861
Comparative bioavailability of betahistine tablet formulations administered in healthy subjects (2011)

Since the 90% CI for Cmax and AUCs ratios were all within the 80-125% interval proposed by the US Food and Drug Administration Agency, it was concluded that the test formulation is bioequivalent to the reference for both the rate and the extent of absorption.
ANDRUBIS -- 1,000,000 Apps Later: A View on Current Android Malware Behaviors (2014)

Android is the most popular smartphone operating system with a market share of 80%, but as a consequence, also the platform most targeted by malware. To deal with the increasing number of malicious Android apps in the wild, malware analysts typically rely on analysis tools to extract characteristic information about an app in an automated fashion. While the importance of such tools has been addressed by the research community, the resulting prototypes remain limited in terms of analysis capabilities and availability. In this paper we present ANDRUBIS, a fully automated, publicly available and comprehensive analysis system for Android apps. ANDRUBIS combines static analysis with dynamic analysis on both Dalvik VM and system level, as well as several stimulation techniques to increase code coverage. With ANDRUBIS, we collected a dataset of over 1,000,000 Android apps, including 40% malicious apps. This dataset allows us to discuss trends in malware behavior observed from apps dating back as far as 2010, as well as to present insights gained from operating ANDRUBIS as a publicly available service for the past two years.
Reconfigurable Cooperative Intelligent Control Design for Space Missions (2012)

Space satellite network design and operation have become more challenging following emerging advanced applications and the increased number of satellites launched into the Earth orbit each year. This has also occasioned an obvious concern for space situational awareness management, interplanetary communications, post-launch reengineering and post-mission reapplications of spacecraft; these all require adaptive, reconfigurable and multifunctional space systems and networks. Enormous advances aimed at making spacecraft systems reconfigurable, reliable, broadband, and multifunctional have been patented. Consequently, recent space technology patents in reconfigurable and autonomous system designs and architectures have been studied and qualified. This paper presents a reconfigurable space satellite network design that uses cooperative space-borne systems to complement ground-based enhancements. Each network node employs the deterministic multifunctional architecture with packet router interface switch matrix platforms. The reconfigurable cooperative intelligent control (RCIC) design exploits the deterministic and reconfigurable property of field programmable gate array to offer in-situ autonomous control. Four reliable and adaptive space control capability modes have been identified for a robust space satellite network. Furthermore, the control capability has been analysed with recourse to satellite generations. Consequently, a case study reconfigurable space network covering femtosatellites to minisatellites has been designed. The analysis presented in this work promises to enhance small satellite formation and constellations designs and applications. It also enables real-time space surveillance and provides platforms for the reuse of decommissioned satellite systems.
A general method for power flow analysis n MTDC systems (2005)

This paper presents a novel and general approach for the power flow analysis in multiterminal DC systems. A major feature of this approach is the clear demarcation of the controller and the DC network equations which enables the consideration of a variety of converter controls. The method can also handle the constraints on several variables such as DC current (lD), converter control angle(0) and off nominal tap ratio(a).
Future of tissue engineering in rheumatic diseases (2007)

Chronic inflammation during rheumatoid arthritis and degenerative processes during osteoarthritis eventually result in joint destruction. Anti-inflammatory therapies facilitate the inhibition or delay of progressing joint cartilage and bone loss, but do not regenerate these tissues. Surgical procedures are quite unsatisfactory in long-term evaluation and often lead to endoprothetic joint replacement. Present tissue engineering technologies offer new strategies for the treatment of cartilage and bone defects. Here, beyond implantation of cell suspensions, biomaterials combined with tissue-specific cells or mesenchymal stem cells are clinically applied. This review focuses on state-of-the-art and future in situ mesenchymal stem cell-based tissue engineering approaches for joint repair in patients with rheumatic diseases.
An Intelligent Flight Trainer for Initial Entry Rotary Wing Training. (1996)

Abstract : The Army Research Institute (ARI) has developed and demonstrated the UH-1 Training Research Simulator (TRS), and shown it to be effective in providing low-cost, effective simulator-based basic training of initial-entry rotary wing (IERW) maneuvers. The system integrates technologies of distributed computational processing and computer image generators in a configuration that has the potential for minimizing dependence on a dedicated instructor pilot. Six empirical studies have demonstrated the system's effectiveness in delivering positive transfer-of-training to the UH-1 helicopter, and further studies are planned to expand the evaluation effort's scope. A need has existed, however, to improve the instructional portions of the system by incorporating instructor pilot (IP) domain knowledge, and by providing the student pilot (SP) with appropriate tutorial feedback regarding proficiency progress. By doing so significant savings in IP hours could be realized to complement the savings already achieved through the low-cost hardware configuration. Of perhaps greater significance was the potential of demonstrating how intelligent tutoring systems (ITSs) could be hybridized with flight training simulators to support the development of a new generation of low-cost intelligent flight trainers (IFTs). The potential thus existed far beyond the UH-1 TRS, and may have significant impact on several other existing and planned flight trainers.
Analog and Digital Performance of Multiple Discrete Time Delays based on a Fiber Loop with an Internal Frequency Shifter (2017)

A fiber loop with an internal frequency shifter is used to produce the delayed copies of an incoming data signal. The linear phase response of the system is verified and the spurious free dynamic range (SFDR) is measured. Also, the BER and constellation diagrams of 10Gbaud QPSK signals are obtained.
Adipose tissue macrophages: phenotypic plasticity and diversity in lean and obese states (2011)

ATMs play a key role in shaping the inflammatory milieu within adipose tissue, and it is now apparent that ATM heterogeneity is acutely shaped by the adipose tissue environment. To account for the new findings, we propose a new nomenclature for ATM subtypes that takes into account their diversity.
A qualitative perspective on idempotency defect of a single-Cooper-pair box placed inside a phase-damped cavity (2008)

In a recent paper Dajka, this http URL., [J. Phys. A \textbf{40}, F879 (2007)] predicted that some composite systems can be entangled forever even if coupled with a thermal bath. We analyze the transient entanglement of a single-Cooper-pair box biased by a classical voltage and irradiated by a quantized field and find the unusual feature that the phase-damped cavity can lead to a long-lived entanglement. The results show an asymptotic value of the idempotency defect (concurrence) which embodies coherence loss (entanglement survival), independent of the interaction development by dependent critically on environment.
THE EFFECT OF THE POXVIRUS OF THE SPRUCE BUDWORM, CHORISTONEURA FUMIFERANA (LEPIDOPTERA: TORTRICIDAE), ON MAMMALS AND BIRDS (1972)

Abstract Laboratory-bred rats and mice fed heavy doses of the poxvirus of the spruce budworm showed no ill effects and made normal weight gains as compared with controls over a period of 8 weeks, and no deaths occurred in the treated groups. Laboratory and wild mammals exposed to aerial spray in open-topped cages similarly showed no adverse effects. Population densities, fecundity, and other pertinent life history parameters of small mammals and birds were studied relative to treatment of a forest with the poxvirus for control of spruce budworm. There were no observable interactions between these small vertebrates and the virus. It is concluded that, from the standpoint of homoiothermic vertebrates, the virus is a safe insecticide.
Mercuric iodide room temperature gamma-ray detectors (1990)

High resolution mercuric iodide room temperature gamma‐ray detectors have excellent potential as an essential component of space instruments to be used for high energy astrophysics. Mercuric iodide detectors are being developed both as photodetectors used in combination with scintillation crystals to detect gamma‐rays, and as direct gamma‐ray detectors. These detectors are highly radiation damage resistant. The list of applications includes gamma‐ray burst detection, gamma‐ray line astronomy, solar flare studies, and elemental analysis.