gebhart/patrepeval huggingface dataset:
Improved risk stratification in myeloma using a microRNA‐based classifier (2013)

Multiple myeloma (MM) is a heterogeneous disease. International Staging System/fluorescence hybridization (ISS/FISH)-based model and gene expression profiles (GEP) are effective approaches to define clinical outcome, although yet to be improved. The discovery of a class of small non-coding RNAs (micro RNAs, miRNAs) has revealed a new level of biological complexity underlying the regulation of gene expression. In this work, 163 presenting samples from MM patients were analysed by global miRNA profiling, and distinct miRNA expression characteristics in molecular subgroups with prognostic relevance (4p16, MAF and 11q13 translocations) were identified. Furthermore we developed an "outcome classifier", based on the expression of two miRNAs (MIR17 and MIR886-5p), which is able to stratify patients into three risk groups (median OS 19.4, 40.6 and 65.3 months, P = 0.001). The miRNA-based classifier significantly improved the predictive power of the ISS/FISH approach (P = 0.0004), and was independent of GEP-derived prognostic signatures (P < 0.002). Through integrative genomics analysis, we outlined the potential biological relevance of the miRNAs included in the classifier and their putative roles in regulating a large number of genes involved in MM biology. This is the first report showing that miRNAs can be built into molecular diagnostic strategies for risk stratification in MM.
Transcriptional regulation of the redD transcriptional activator gene accounts for growth‐phase‐dependent production of the antibiotic undecylprodigiosin in Streptomyces coelicolor A3(2) (1992)

Transcription of redD, the activator gene required for production of the red-pigmented antibiotic undecylprodigiosin by Streptomyces coelicolor A3(2), showed a dramatic increase during the transition from exponential to stationary phase. The increase in redD expression was followed by transcription of redX, a biosynthetic structural gene, and the appearance of the antibiotic in the mycelium, and coincided with the intracellular appearance of ppGpp. However, ppGpp production elicited either by nutritional shift-down of, or addition of serine hydroxamate to, exponentially growing cultures had no stimulatory effect on redD transcription. The presence of redD on a multicopy plasmid resulted in elevated levels of the redD transcript and production of redX and undecylprodigiosin during exponential growth; the normal growth-phase-dependent production of undecylprodigiosin appeared to be mediated entirely through the redD promoter, which shows limited similarity to the consensus sequence for the major class of eubacterial promoters.
Epidemiology of hepatitis B in the Islamic Republic of Iran (2021)

Hepatitis B virus, a common cause of viral hepatitis, consumes a large portion of health resources in developing countries. Data obtained from the Survey of Health and Disease in the Islamic Republic of Iran were analysed with respect to hepatitis B-carrier epidemiology. Since the precise mode of transmission of hepatitis B is not well known, the study was designed to evaluate its transmission as a community-acquired disease. HBsAg tests were performed on the sera of 39 841 persons and the impact of several factors on the prevalence rate of HBV carriers was determined. The rate of hepatitis B carriers varied between zero and 3.9% with an average of 1.7%. Older males living in a village with low socioeconomic status, poor sanitation and intrafamily contact are the most important contributors to the rise of hepatitis B infection in the country
Structural effects of monovalent anions on polymorphic lysozyme crystals (2001)

Understanding direct salt effects on protein crystal polymorphism is addressed by comparing different crystal forms (triclinic, monoclinic, tetragonal and orthorhombic) for hen, turkey, bob white quail and human lysozymes. Four new structures of hen egg-white lysozyme are reported: crystals grown in the presence of NapTS diffracted to 1.85 A, of NaI to 1.6 A, of NaNO(3) to 1.45 A and of KSCN to 1.63 A. These new structures are compared with previously published structures in order to draw a mapping of the surface of different lysozymes interacting with monovalent anions, such as nitrate, chloride, iodide, bromide and thiocyanate. An analysis of the structural sites of these anions in the various lysozyme structures is presented. This study shows common anion sites whatever the crystal form and the chemical nature of anions, while others seem specific to a given geometry and a particular charge environment induced by the crystal packing.
Epigenetics, Behaviour, and Health (2008)

: The long-term effects of behaviour and environmental exposures, particularly during childhood, on health outcomes are well documented. Particularly thought provoking is the notion that exposures to different social environments have a long-lasting impact on human physical health. However, the mechanisms mediating the effects of the environment are still unclear. In the last decade, the main focus of attention was the genome, and interindividual genetic polymorphisms were sought after as the principal basis for susceptibility to disease. However, it is becoming clear that recent dramatic increases in the incidence of certain human pathologies, such as asthma and type 2 diabetes, cannot be explained just on the basis of a genetic drift. It is therefore extremely important to unravel the molecular links between the "environmental" exposure, which is believed to be behind this emerging incidence in certain human pathologies, and the disease's molecular mechanisms. Although it is clear that most human pathologies involve long-term changes in gene function, these might be caused by mechanisms other than changes in the deoxyribonucleic acid (DNA) sequence. The genome is programmed by the epigenome, which is composed of chromatin and a covalent modification of DNA by methylation. It is postulated here that "epigenetic" mechanisms mediate the effects of behavioural and environmental exposures early in life, as well as lifelong environmental exposures and the susceptibility to disease later in life. In contrast to genetic sequence differences, epigenetic aberrations are potentially reversible, raising the hope for interventions that will be able to reverse deleterious epigenetic programming.
Effects of intravesical onabotulinumtoxinA on bladder dysfunction and autonomic dysreflexia after spinal cord injury: role of nerve growth factor (2011)

The results of the present study showed that intravesical onabotA controls neurogenic detrusor overactivity and AD after SCT. The findings shed light on the potential benefits of intravesical onabotA treatment in patients with spinal cord injury, and also provide a novel mechanism for the control of AD via a minimally invasive treatment modality.
A general, high-yield reaction for the formation of (chloromethyl)oligosilanes (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA general, high-yield reaction for the formation of (chloromethyl)oligosilanesToshiaki Kobayashi and Keith H. PannellCite this: Organometallics 1990, 9, 8, 2201–2203Publication Date (Print):August 1, 1990Publication History Published online1 May 2002Published inissue 1 August 1990https://pubs.acs.org/doi/10.1021/om00158a012https://doi.org/10.1021/om00158a012research-articleACS PublicationsRequest reuse permissionsArticle Views305Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A 5.184Gbps/ch through-chip interface and automated place-and-route design methodology for 3-D integration of 45nm CMOS processors (2012)

We propose 3-D integrated mobile phone system utilizing an inductive-coupling link. To realize energy efficient 3-die stacking, a slew-rate controlled footer switch scheme and a superposition of magnetic field scheme are proposed. By using a place-and-route model of a coil, we demonstrate that a commercial layout tool can handle the inductive-coupling link module successfully. Performance of the proposed circuit is estimated as 5.184Gbps/ch and 6.1pJ/b for 2-die stacking and 9.5pJ/b for 3-die stacking. The area efficiency is 592μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> /Gbps, which is 1/330 of the prior art.
Motion artifact suppression in the ECG signal by successive modifications in frequency and time (2013)

Ambulatory electrocardiogram signals can be contaminated with various types of noise. Among these, electrode motion 'em' artifacts are considered particularly undesired as they can be mistaken for ectopic beats. Unfortunately, 'em' noise has proved difficult to tackle using ordinary filtering techniques. In this paper, we explore a novel filtering alternative, and show that it could be considered as a potential candidate for dealing with electrode motion artifacts. The proposed system is composed of two simple parts: a frequency filter and a time window, interconnected in series. The two components are designed such that the overall system operates optimally in the mean square error sense. Experimentation on signals obtained from the MIT-BIH database demonstrates the superiority of the above approach over optimal Fourier filtering.
Molecular diagnostics of human pathogenic Aspergillus species (2011)

Eight species of Aspergillus (A. hiratsukae, A. flavus, A. fumigatus, A. terreus, A. niger, A. sydowii, A. clavatus and A. flavipes ) were found associated with clinical samples causing human diseases. The nonspecific symptoms and lack of rapid diagnostics is a major problem in treating patients suffering from invasive aspergillosis. Molecular markers based on RAPD primers and diversity in ITS region of 5.8S rRNA gene developed for rapid diagnosis facilitated early treatment of patient suffering from aspergillosis related disorders. Direct sequencing of amplified ITS products revealed significant single nucleotide polymorphism, which facilitated identification of pathogenic Aspergillus species associated with aspergillosis. The complete sequences of eight Aspergillus species were submitted to NCBI database, USA, which were assigned new Gen accession numbers EU515147 to EU515154 and now available in public domain for comparison.
Infrared Neural Stimulation of Thalamocortical Brain Slices (2009)

Infrared neural stimulation (INS) has been well characterized in the peripheral nervous system, and has been shown to enable stimulation with high spatial precision and without causing the typical electrical stimulation artifact on the recording electrode. The next step in the development of INS is to demonstrate feasibility to stimulate neurons located in the central nervous system (CNS). Thalamocortical brain slices were used to establish feasibility of INS in the CNS and to optimize laser parameters. Infrared light was used to evoke action potentials in the brain slice with no electrical stimulation artifact. This response was blocked by the application of tetrodotoxin demonstrating neurological origin of the recorded signal. Threshold radiant exposure decreased as the absorption coefficient of the wavelength of light increased. Higher repetition rates lead to a decrease in threshold radiant exposure, and threshold radiant exposure was found to decrease as the spot size diameter increased. Additionally, neuronal responses to INS were intracellularly recorded demonstrating artifact free electrical recordings. The results from this paper lay the foundation for future in vivo studies to develop INS for CNS stimulation.
ChemInform Abstract: PHOTOISOMERIZATION OF 4‐HYDROXYPYRYLIUM CATIONS IN CONCENTRATED SULFURIC ACID (1985)

Abstract Zahlreiche alkylierte 4‐Hydroxy‐pyrylium‐Kationen wie (III) werden photolytisch isomerisiert.
Electric field deflection of molecules with large amplitude motions (1975)

The Stark effect is derived for several plausible models for molecules such as XeF6 and IF7 which are believed to show pseudorotation or other large-amplitude internal motion. These results are related to the behavior of these molecules in electric-field-deflection molecular beam experiments. The absence of focusing of XeF6 is compatible with an effective dipole moment of distorted XeF6 of up to 1.2 D for free pseudorotation but only 0.2 D if pseudorotation is restricted by a potential barrier with C4v orientation 770 cm−1 above C3v. Additional examples are treated for XeF6 as well as models appropriate to the MX7 molecules.
Pouch—vaginal fistula (1993)

Between January 1976 and June 1991, 161 women underwent restorative proctocolectomy. Seventeen (10.6 per cent) developed pouch-vaginal fistula. There was no difference in the incidence of inflammatory (15 of 141; 10.6 per cent) and non-inflammatory (two of 20; 10 per cent) disease, the severity of colitis or the number of stages in the operation. In 15 patients the fistula involved the ileoanal anastomosis; in two it had possibly occurred at the dentate line. There was no significant difference in the proportion of hand-sewn (ten of 120; 8.3 per cent) and stapled (seven of 41; 17 per cent) ileoanal anastomosis. Of the 17 women, six had pelvic sepsis in the immediate postoperative period and five had an anastomotic complication. There was no case of Crohn's disease. Three patients developed a pouch-vaginal fistula before closure of the ileostomy. The remaining 14 fistulas occurred a median of 7 (range 1-144) months after closure. Five further patients were referred from elsewhere to give a total of 22 for analysis of treatment and outcome. The fistula developed before ileostomy closure in five patients (group 1) and after closure in 17 (group 2). Following treatment, six fistulas had healed with five patients still undergoing treatment. In group 1, three of the five fistulas healed, whereas in group 2 only three of the 17 healed. Eight patients required excision of the pouch. The prognosis appears to be worse when pouch-vaginal fistula occurs after ileostomy closure. The optimal management is not yet established.
Chemical Preparation of the Eye in Ophthalmic Surgery (1984)

A half-strength povidone-iodine (Betadine) solution was used topically as part of the preoperative chemical preparation of the eye. Aerobic and anaerobic bacterial cultures of the conjunctiva were taken before and after the chemical preparation in 30 consecutive patients; the second eye served as a control. In the control eyes, no significant change in the number of colonies or species of bacteria was found. In the povidone-iodine-treated eyes, the numbers of colonies decreased 91% and the number of species decreased 50% (statistically significant). We therefore recommend that a half-strength povidone-iodine solution be used as part of the chemical preparation of the eye for surgery.
Photochemical behaviour of propranolol in environmental waters: the hydroxylated photoproducts (2011)

The UV irradiation of propranolol, one of the beta-blockers currently used in cardiac medicine, was studied. During irradiation, the samples were analysed by LC/MS/MS, using a Waters Symmetry C18 (3.5 µm 150 × 2.1 mm) column. The main photoproducts were identified from mono-, di- and tri-hydroxylation of the propranolol naphthalenic skeleton. Hydroxyl group positions were predicted by means of theoretical calculations. Partial charge calculations of the propranolol atoms predicted the formation of four mono-hydroxylated compounds, two of them being the most probable. From these two compounds, three di-hydroxylated compounds were predicted. Then the calculations from the two most probable di-hydroxylated compounds were used to propose three tri-hydroxylated propranolol compounds. It was found that the same hydroxylated photoproducts are formed in pure water and in treatment plant waste water.
REALISATION OF STRUCTURAL BATTERY COMPOSITE MATERIALS (2015)

The paper presents details on the development of carbon fibre structural battery composite materials, and their devices, and the rationale for developing them.
Rearrangements of the BCL6 gene in diffuse large cell non-Hodgkin's lymphoma (1994)

The pathogenesis of non-Hodgkin's lymphoma (NHL) with a large cell component (DLLC, including diffuse large cell, DLCL; diffuse mixed cell, MX-D; and immunoblastic, IMB) is unknown. A novel candidate proto-oncogene, BCL6, that is involved in chromosome band 3q27 aberrations in NHL has been recently identified. We have investigated the incidence and disease-specificity of BCL6 rearrangements in a large panel of lymphoid tumors, including acute and chronic lymphoid leukemias (96 cases), various NHL types (125 cases), and multiple myelomas (23 cases). BCL6 rearrangements were found in 16/45 (35.5%) DLLC, more frequently in DLCL (15/33, 45%) than in MX-D (1/10, 10%), in 2/31 (6.4%) follicular NHL, and in no other tumor types. BCL6 rearrangements represent the first genetic lesion specifically and recurrently associated with DLLC and should prove useful for understanding the pathogenesis as well as for the clinical monitoring of these tumors.
Modulated cholecystokinin (CCK) mRNA expression is dependent on de novo protein synthesis. (1993)

The human neuroblastoma cell line SK-N-MC expresses cholecystokinin (CCK) and c-fos mRNA. Levels of CCK and c-fos mRNA expression were studied by nuclear run-off transcription and Northern blot analysis. Addition of foetal calf serum or forskolin to the medium stimulated basal CCK and c-fos mRNA expression. Addition of cycloheximide suppressed the stimulation of CCK mRNA expression, whereas expression of c-fos mRNA was super-induced by the simultaneous addition of cycloheximide and forskolin or foetal calf serum. Western blot analysis revealed that c-fos mRNA is translated into Fos. Expression of c-fos in SK-N-MC cells suggests that Fos may be part of a functional transcription complex and that it may be involved in the regulation of basal and stimulated CCK mRNA expression in SK-N-MC cells.
Editorial: fate mapping of human glioblastoma reveals an invariant stem cell hierarchy (2018)

Glioblastoma (GB) is the most aggressive primary brain cancer of adulthood, associated with an average 5-year survival rate of 2% (1). A small population of tumor-initiating cells, termed cancer stem cells (CSCs), are the putative origin of GB, accounting for tumor development, progression and recurrence (2).
A subgroup of murine monoclonal anti-deoxyribonucleic acid antibodies traverse the cytoplasm and enter the nucleus in a time-and temperature- dependent manner. (1994)

This is the first demonstration that monoclonal autoantibodies can traverse both the cell and nuclear membranes to localize within the nuclei of cultured cells. Furthermore, nuclear localization of Ig was regulated in a manner analogous to that of other large cytoplasmic proteins that enter the nucleus. This confirms and extends our results using the same antibodies in whole animals, and it provides the basis to further examine the underlying mechanisms and consequences of this phenomenon.
Nanoscopic Strength Analysis of Tempered-Martensitic Steels. (2002)

The relationships between tensile strength and microstructural parameters and between fatigue limit and microstructural parameters were investigated for seven tempered-martensitic steels S45C, SMn443, SCr440, SNCM439, SCM440, SUP7 and SUP12. An optical and atomic force microscopy showed that prior-austenitic grain diameter, dγ, block width, Wblo, and precipitation spacing, λ, were 18μm, 0.7μm and 0.11∼0.24μm, respectively, as microstructural parameters. A nanoindentation showed that HV=100+Hv*dls+Hv*pre+Hv*bou, where Hv is macro-Vickers hardness, and Hv*pre and Hv*bou are micro-covered Vickers hardness due to dislocation and solid, precipitation and block boundary strengthening. Hv*pre and Hv*bou were expressed by the microstructural parameters of λ and Wblo. The constant value of 100 is base hardness of the iron. Based on these results, we proposed that tensile strength σB and fatigue limit σw, were expressed in the followings. σB=3.27{100 + Hv*dls + 1.02 × 10-2λ-1 + 3.67 × 10-4λ-1w-1/2blo}…………………………………(A-1) σw=1 .6{100 + Hv*dls + 1.02 × 10-2λ-1 + 1.15(3.67 × 10-4λ-1w-1/2blo)}…………………………(A-2)
GEMs: shared-memory parallel programming for Node.js (2016)

JavaScript is the most popular programming language for client-side Web applications, and Node.js has popularized the language for server-side computing, too. In this domain, the minimal support for parallel programming remains however a major limitation. In this paper we introduce a novel parallel programming abstraction called Generic Messages (GEMs). GEMs allow one to combine message passing and shared-memory parallelism, extending the classes of parallel applications that can be built with Node.js. GEMs have customizable semantics and enable several forms of thread safety, isolation, and concurrency control. GEMs are designed as convenient JavaScript abstractions that expose high-level and safe parallelism models to the developer. Experiments show that GEMs outperform equivalent Node.js applications thanks to their usage of shared memory.
A first step towards call survivability in cellular networks (2005)

Despite recent advancements in cellular phone network infrastructure, survivability of the calls is still an open issue. Important business calls and tele-conferences cannot benefit from mobility because landlines are preferred owing to their reliability and tolerance to failures. In this paper, we present a framework to improve call survivability by monitoring the user's location and intimating him about the possibility of loss of connectivity, interference, and room schedules that might disrupt conversation. In addition, if a call drops because of unforeseeable circumstances like battery failure or cell-phone damage then the call is switched to the nearest available device capable of streaming voice
Space-Time Coding and Signal Processing for High Data Rate Wireless Communications (2005)

The information capacity of wireless communication systems can be increased dramatically by employingmultiple transmit and receive antennas [?, ?]. An effective approach to increasing data rate over wireless channels is to employ coding techniques appropriate to multiple transmit antennas, that is space-time coding. Space-time codes introduce temporal and spatial correlation into signals transmitted from different antennas, in order to provide diversity at the receiver, and coding gain over an uncoded system. The spatial-temporal structure of these codes can be exploited to further increase the capacity of wireless systems with a relatively simple receiver structure. This chapter provides an overview of space-time coding techniques and the associated signal processing framework.
Rabies Postexposure Prophylaxis in Returned Injured Travelers From France, Australia, and New Zealand: A Retrospective Study (2008)

This study highlights important deficiencies in rabies PEP for travelers who acquire high-risk, animal-associated injuries in rabies-endemic countries, with the majority not receiving adequate PEP or experiencing a substantial delay before receiving rabies vaccination.