gebhart/patrepeval huggingface dataset:
Catheter-directed laser coagulation of atrial myocardium in dogs (1994)

The feasibility of transcatheter laser coagulation of atrial myocardium was tested in a canine model by using a combined electrode-laser catheter. In 17 anaesthetized beagles a total of 264 lesions, 12-19 per dog, and 3-5 in each area were produced in: (1) the lateral walls, (2) the posterior right atrial walls, (3) the inter-atrial septum, and (4) the atrial appendage. The power source was a continuous wave Nd:YAG laser. Irradiance was 1 kW.cm-2, at a wave length of 1064 nm, the irradiated spot diameter was 2.0-2.5 mm, and the pulse duration 5-60 s. Local intra-cardiac atrial potentials recorded from the targeted areas during laser irradiation dwindled after onset of the laser pulse, and their amplitude was reduced persistently by pulses of 15 s or longer. Histopathologically, the acute lesions showed intramural haemorrhage and coagulation necrosis, but there was no tissue vaporization or crater formation. Chronic lesions showed clear-cut oval-shaped areas of transmural fibrosis. Diameters of lesions, dependent on the amount of laser energy applied, measured from 4.6 +/- 0.5 mm (450 J) to 7.8 +/- 1.4 mm (1800 J). Follow-up lasted 6-25 months (average 10.5). All the animals survived the procedure without complications. Transcatheter laser coagulation of atrial myocardium is safe and can be performed in a controllable manner by using the catheter system presented.
Kinetics of High Pressure Oxidation of Silicon in Pyrogenic Steam (1981)

The kinetics of high pressure oxidation of silicon in pyrogenic steam were investigated for ambient pressures of 5–20 atm and for oxidation temperatures of 800°–1000°C. A linear‐parabolic model was used in the analysis of the data. Both rate constants of the analytic model were found to be linearly proportional to pressure for the entire range of temperature and pressure. Fixed oxide charge and interface state densities for oxides grown at high pressure were found to be slightly higher at lower temperatures, particularly below 900°C, than for oxides grown at 1 atm. Electron trapping by avalanche injection in oxides grown on (111) Si at 5 atm in pyrogenic steam (800°C) yielded effective trap densities and capture cross sections similar to those obtained at 1 atm.
\nThe Theory of Timed I/O Automata, Second Edition (2010)

\n Contains fulltext :\n 83938.pdf (Publisher’s version ) (Open Access)\n
Parallel feature selection based on the trace ratio criterion (2022)

The growth of data today poses a challenge in management and inference. While feature extraction methods are capable of reducing the size of the data for inference, they do not help in minimizing the cost of data storage. On the other hand, feature selection helps to remove the redundant features and therefore is helpful not only in inference but also in reducing management costs. This work presents a novel parallel feature selection approach for classification, namely Parallel Feature Selection using Trace criterion (PFST), which scales up to very large datasets. Our method uses trace criterion, a measure of class separability used in Fisher's Discriminant Analysis, to evaluate feature usefulness. We analyzed the criterion's desirable properties theoretically. Based on the criterion, PFST rapidly finds important features out of a set of features for big datasets by first making a forward selection with early removal of seemingly redundant features parallelly. After the most important features are included in the model, we check back their contribution for possible interaction that may improve the fit. Lastly, we make a backward selection to check back possible redundant added by the forward steps. We evaluate our methods via various experiments using Linear Discriminant Analysis as the classifier on selected features. The experiments show that our method can produce a small set of features in a fraction of the amount of time by the other methods under comparison. In addition, the classifier trained on the features selected by PFST not only achieves better accuracy than the ones chosen by other approaches but can also achieve better accuracy than the classification on all available features.
Persistent luminescence properties of monoclinic luminescent zirconium oxide annealed under different oxygen partial pressures (2020)

Luminescent zirconium oxide (ZrO2) with high purity (>3N) was annealed under different oxygen partial pressures (Po2 = 10−14–104 Pa) to investigate the effect of lattice defects on persistent luminescence (PersL). Although the Photoluminescence spectra profiles of samples (broad band emission centered at 485 nm) matched with the PersL spectra, PersL durations differed depending on the value of Po2 during annealing. Samples annealed under a medium value of Po2 such as 1 Pa tended to show long PersL duration. The two main trap levels were evaluated from thermoluminescence glow curves, and the ratio of two traps changed depending on the value of Po2 during annealing. The time profiles of intensities of EPR signals (which assigned to F+-center and hole-trapped oxygen) were linked to the time profiles of luminescence intensities under and after ultraviolet irradiation. This result indicates that the F+-center and hole-trapped oxygen are involved in PersL.
GARCH Model with Cross-sectional Volatility; GARCHX Models (2001)

This study introduces GARCH models with cross-sectional market volatility, which are called GARCHX models. The cross-sectional market volatility is a special case of common heteroscedasticity in asset specific returns, which is suggested by Connor and Linton (2001) as an important component in individual asset volatility. Using UK and US data, we find that daily return volatility can be better specified with GARCHX models, but GARCHX models do not necessarily perform better than conventional GARCH models in forecasting.(This abstract was borrowed from another version of this item.)
Structure, properties, and inversion of the Ar⋅SO2 van der Waals molecule (1980)

Microwave and radiofrequency spectra of the Ar⋅SO2 van der Waals molecule have been studied by molecular beam spectroscopy. The molecule has Cs point group symmetry and tunnels through a very low barrier at a C2v structure at a 980 MHz rate. The tunneling interchanges the two oxygen atoms which causes half of each inversion doublet to have zero statistical weight. The inversion frequency and assumptions about the bending vibration lead to a barrier height of ?10 cm−1. Stark effect measurements give μa=0.2674 D, μb=0.0 D, μc=1.465 D. These moments are interpreted in terms of a vibrational amplitude of 24° associated with the inversion coordinate. The geometry of the complex is essentially perpendicular with the Ar atom above the plane of SO2 and located almost directly over the SO2 center-of-mass at a 3.675 Å distance.
Etude du mode de colonisation des graines et des siliques de la plante modèle Arabidospis thaliana par Alternaria brassicicola, champignon pathogène des plantes de la famille des Brassicacées (2011)

National audience
Sonic properties of rocks under confining pressure using the resonant bar technique (1991)

This paper presents in detail the resonant bar technique used to measure acoustic properties of materials in the sonic frequency range (≃5–20 kHz). Measurements are corrected for the effects of added mass and jacketing; extrinsic effects such as the sample diameter or the dispersion at higher frequencies can mask intrinsic properties of material and are analyzed here. When this technique is used on porous saturated media such as rocks, it is important to avoid the “Biot–Gardner–White” effect; this intrinsic effect can lead to erroneous high attenuations in unjacketed saturated samples. Experimental evidence of its occurrence on water-saturated rods is presented. Experimental results of velocity and attenuation obtained on various rock types such as limestones and sandstones show the drastic sensitivity of these measurements to effective pressure. Hertz’s theory can be applied to describe the behavior of under-consolidated sandstones. Under high confining pressure, sonic attenuation in water-saturated limestone samples is found to be very low (Q⩾100); attenuation in sandstones is always low (Q⩾50), except for some shaly sandstones.
Creating psychotherapy for a sustainable future (2004)

This paper asks how psychotherapy needs to change in the service of creating a sustainable future. It examines the meaning of sustainability and explores the concept of self in relation to nature and culture, with the help of descriptions from an indigenous cosmology. The paper asks how we identify with the larger whole, and why we disidentify and disconnect from it, and suggests that psychotherapy is a powerful tool for reconnection with our world, but that it would benefit from expanding beyond its human-centredness, to embrace our relationship with the other-than-human world. This would involve relating to nature as subject and embracing our anthropocentrism. The paper questions how this might play itself out both in our everyday lives, and within our internal worlds. Copyright © 2004 Whurr Publishers Ltd.
Differential neointimal response to coronary artery injury in pigs and dogs. Implications for restenosis models. (1994)

Neointimal hyperplasia occurs in the coronary arteries after percutaneous revascularization procedures and is a reparative response that frequently causes recurrent stenosis. Prior animal studies have shown that neointimal tissue thickness is proportional to the depth of arterial injury. Because animal models are increasingly used to test therapeutic strategies against restenosis, the purpose of this study was to evaluate the degree of neointimal thickening formed in the coronary arteries of pigs compared with dogs in response to severe injury. Fourteen coronary arteries in six mongrel dogs and 18 coronary arteries in nine pigs underwent severe arterial injury using tantalum metal coils delivered on oversized angioplasty balloons. Animals were killed after 4 weeks, and all coronary arteries were pressure perfusion fixed. Mean histological injury scores and neointimal thicknesses for dogs were 1.9 +/- 0.3 and 0.30 +/- 0.11, respectively, compared with 2.1 +/- 0.7 and 0.71 +/- 0.36 for pigs. Thus, there was significantly less neointimal thickening in dogs compared with pigs (P < .001) despite no differences in injury (P = NS). The neointimal thickening differences translated into significantly different percent area stenoses: 55 +/- 24% for pigs versus 27 +/- 13% for dogs (P < .001). Linear regression modeled neointimal thickness versus injury assessed by an ordinal injury score proportional to the depth of injury for each species. This analysis confirmed the differences across multiple injury levels. The slope of the regression line for dogs was small, suggesting that no relation may exist between injury and neointimal thickness in this species. The pig may be a more appropriate model for the study of the genesis of stenosing neointima.(ABSTRACT TRUNCATED AT 250 WORDS)
Recommending Join Queries Based on Path Frequency (2015)

Real databases often consist of hundreds of innerlinked tables, which makes posing a complex join query a really hard task for common users. Join query recommendation is an effective technique to help users formulate better join queries and explore their information demand. In this paper, we propose a novel approach to automatically create join query recommendations based on path frequency. Our approach generates recommendations by analyzing the database schema and underlying data. First, we exploit join queries which are likely to be queried by considering both the importance and the connectivity of tables. Second, we provide users two recommendation forms. One needs no input information and the other allows users to input incomplete information. Users can choose one according to their knowledge. Extensive evaluations demonstrate the effectiveness of our approach and show that our method is helpful to formulate good join queries in practice.
Supplementary Materials and Methods from Bone Metastasis of Prostate Cancer Can Be Therapeutically Targeted at the TBX2–WNT Signaling Axis (2023)

&lt;p&gt;Supplementary Materials and Methods&lt;/p&gt;
Where Shall I Live? Economics of Living Among the Migrant Workers (2011)

The key take-away from this chapter is that social issues, such as housing and the nature of city life, can be addressed by the same experiments as we addressed actual products. Social policy, therefore, and the nature of what people want and what they will sacrifice, becomes, at least in terms of experimentation, one more example of how research methods apply to a variety of different economic and social topics. That is, understanding the public sector is probably no more difficult than understanding the private sector. Nor is it difficult to export the research method to other countries, other cultures. With simply sensitivity to the local problems of the population the tool which provides knowledge about how to sell products to people also now provides knowledge about how to sell public policy to waiting citizens.
NMR Spectroscopic Analysis of the DNA Conformation Induced by the Human Testis Determining Factor SRY (1995)

The conformation of an eight base pair DNA oligonucleotide duplex bound to the human testis determining factor SRY and the orientation of the protein domain within the complex have been analyzed by a variety of NMR methods which permit the selective observation of protons attached to 12C nuclei in the presence of uniformly enriched 13C/15N protein. Qualitative analysis of nuclear and rotating frame Overhauser enhancement spectra at multiple mixing times indicates that the conformation of the SRY-bound DNA is distinct from that of A- and B-DNA, in agreement with the recent three-dimensional structure determination of the complex [Werner, M. W., Huth, J. R., Gronenborn, A. M., & Clore, G. M. (1995) Cell 81, 705-714]. Selective observation of intermolecular NOEs between protein and DNA indicates that partial intercalation of a protein side chain occurs between two adenine bases in the DNA octamer. The analysis of structural features by NMR for this unusual DNA conformer and the orientation of the protein domain on the DNA is discussed. The structural features of the DNA complexed to SRY are remarkably similar, but not identical, to those of DNA complexed to the TATA-binding protein (TBP).
Interplay between Intra‐ and Interligand Charge Transfer with Variation of the Axial N‐Heterocyclic Ligand in Osmium(II) Pyridylpyrazolate Complexes: Extensive Color Tuning by Phosphorescent Solvatochromism (2005)

The rational design and syntheses of a new series of Os(II) complexes with formula [Os(fppz)(2)(CO)(L)] (1: L=4-dimethylaminopyridine; 2: L = pyridine; 3: L = 4,4'-bipyridine; 4: L = pyridazine; 5: L = 4-cyanopyridine), bearing two (2-pyridyl)pyrazolate ligands (fppz) together with one carbonyl and one N-heterocyclic ligand at the axial positions are reported. Single-crystal X-ray diffraction studies of, for example, 2 reveal a distorted octahedral geometry in which both fppz ligands reside in the equatorial plane with a trans configuration and adopt a bent arrangement at the metal center with a dihedral angle of approximately 23 degrees , while the carbonyl and pyridine ligands are located at the axial positions. Variation of the axial N-heterocyclic ligand leads to remarkable changes in the photophysical properties as the energy gap and hence the phosphorescence peak wavelength can be tuned. For complexes 1 and 2 the solvent-polarity-independent phosphorescence originates from a combination of intraligand (3)pi-pi* ((3)ILCT) and metal-to-ligand charge transfer transitions ((3)MLCT). In sharp contrast, as supported by cyclic voltammetry measurements and theoretical calculations, complexes 3--5 exhibit mainly ligand-to-ligand charge transfer (LLCT) transitions, resulting in a large dipolar change. The phosphorescence of complexes 3--5 thus exhibits a strong dependence on the polarity of the solvent, being shifted for example, from 560 (in C(6)H(12)) to 665 nm (in CH(3)CN) and from 603 (in C(6)H(12)) to 710 nm (in CH(3)CN) for complexes 3 and 5, respectively. The results clearly demonstrate that a simple, straightforward derivatization of the axial N-heterocyclic ligand drastically alters the excitation properties per se from intraligand charge transfer (ILCT) to LLCT transitions. The latter exhibit remarkable LLCT phosphorescence solvatochromism so that a broad range of color tunability can be achieved.
Analogies between structural and systems biology and systems-of-systems engineering in dynamic environments (2010)

Computer science and biology have inspired each other by drawing analogies. Biological molecules are even used directly as new material building blocks for creating next generation computer hard- and software. Recently, biology is moving to larger scales, generating datasets of high complexity and size. This allows moving from studies of individual biological entities such as proteins to their complex networks of interactions. Since cells are able to respond to perturbations over time, it is becoming an important variable in these studies. This is analogous to systems of systems engineering to operate in dynamic environments, requiring the efficient monitoring of external variables and intelligent choice of adequate responses. Here, we survey previous successes in exploiting analogies between biology and computer science and propose novel avenues and potential for cross-fertilization of research in dynamic systems modeling in biology and systems-of-systems engineering.
Functional substitution for TAFII250 by a retroposed homolog that is expressed in human spermatogenesis (2002)

TAF(II)250, the largest subunit of the general transcription factor TFIID, is expressed from the human X chromosome, at least in somatic cells. In male meiosis, however, the sex chromosomes are transcriptionally silenced, while the autosomes remain active. How then are protein-encoding genes transcribed during human male meiosis? Here we present a novel autosomal human gene, TAF1L, which is homologous to TAF(II)250 and is expressed specifically in the testis, apparently in germ cells. We hypothesize that during male meiosis, transcription of protein-encoding genes relies upon TAF1L as a functional substitute for TAF(II)250. Like TAF(II)250, the human TAF1L protein can bind directly to TATA-binding protein, an essential component of TFIID. Most importantly, transfection with human TAF1L rescued the temperature-sensitive lethality of a hamster cell line mutant in TAF(II)250. TAF1L lacks introns and evidently arose by retroposition of a processed TAF(II)250 mRNA during primate evolution. The observation that TAF1L can functionally replace TAF(II)250 provides experimental support for the hypothesis that during male meiosis, autosomes provide cellular functions usually supplied by the X chromosome in somatic cells.
Protocol for a multicentre, prospective, cohort study to investigate patient satisfaction and quality of life after immediate breast reconstruction in Japan: the SAQLA study (2021)

UMIN000032177.
Supplementary Figures from Target-Based Screening against eIF4A1 Reveals the Marine Natural Product Elatol as a Novel Inhibitor of Translation Initiation with <i>In Vivo</i> Antitumor Activity (2023)

&lt;p&gt;Figure S1. Elatol was submitted to a 96-member kinome screen to evaluate specificity. Figure S2. A) Michaelis-Menten curves of eIF4A1 wild type (blue), K82R (red), and K238E (green). Michaelis- Menten constants for eIF4A1 wild type and mutants in table on the left. B) Chemical structures of elatol and three other known eIF4A inhibitors. Figure S3. A) Cell viability following 72h carbopaltin treatment measured using Cell Titer Glo. Figure S4. A) Western blot showing protein expression of translationally regulated genes in RIVA cells treated with DMSO Figure S5. A) Western blot analysis of MDA-MB-468 breast cancer cells transfected with 50nM ATF4 siRNA or a non-targeting control (NT). Figure S6. A) Mouse weights measured twice weekly during first maximum tolerated dose study.&lt;/p&gt;
The Solution Structure of the Pleckstrin Homology Domain of Human SOS1 (1997)

A large subset of pleckstrin homology (PH) domains are immediately to the C terminus of diffuse B cell lymphoma (Dbl) homology (DbH) domains. Dbl domains are generally considered to be GTPase-exchange factors; many are proto-oncogenes. PH domains appear to function as membrane-recruitment factors, or have specific protein-protein interactions. Since dual domain (DbH/PH) constructs are known to have significant properties in other pathways, it is possible that a defined interdomain relationship is required for DbH/PH function. We determined the solution structure of the human SOS1 PH domain for a construct partially extended into the preceding DbH domain. There are specific structural contacts between the PH and the vestigial DbH domain. This appears to involve structural elements common to this subfamily of PH domains, and to DbH domains. The human SOS1 PH domain binds to inositol 1,4,5-triphosphate with a approximately 60 mu M affinity. Using chemical shift titration, the binding site is identified to be essentially identical to that observed crystallographically for the inositol 1,4,5-triphosphate complex with the PH domain of phospholipase Cdelta. This site may serve as an interdomain regulator of DbH or other domains' functions. While the overall fold of the human SOS1 PH domain is similar to other PH domains, the size and position of the intrastrand loops and the presence of an N-terminal alpha-helix of the vestigial DbH domain suggest that the subfamily of PH domains associated with DbH domains may be a well defined structural group in which the PH domain is a membrane recruiter and modulator.
Supplementary Table 8 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia (2023)

&lt;p&gt;RNA PolII Pause Index Analysis from MOLM13 RBP1 CUT&amp;Tag (6 Hours After Drug Treatment)&lt;/p&gt;
[Binding pancreaticojejunostomy: clinical report of 150 cases]. (2002)

The BPJ procedure is effective in avoiding anastomotic leakage following PD.
On-Chip Transmission Line Modeling and Applications to Millimeter-Wave Circuit Design in 0.13um CMOS Technology (2007)

This paper presents the on-chip transmission line modeling and applications to circuit design at millimeter-wave (ram-wave) frequencies. The microstrip model of circuit simulators benefits in fast calculations of the characteristics of microstrip lines. As the structure of on-chip microstrip differs from the modeled structure, two key parameters of the microstrip model need to be modified for the different electromagnetic (EM) behavior according to the measured microstrip line. With proper parameters, the traditional transmission line model is able to accurately predict the real characteristic of on-chip microstrip lines without time-consuming EM simulation. A mm-wave microstrip line filter and a single-stage cascode low noise amplifier (LNA) are fabricated to verify the model. All passive components for input/output matching networks and bias networks are on-chip. The LNA takes the supply voltage and dc current of 1.4 V and 10 mA, respectively. A gain of 3.8 dB and an input/output return loss of 8.5/7.0 dB are measured at 60.3 GHz. The simulation results in both circuits are in good agreement with measured data.
Animal experiments show impact of vaccination on reduction of SARS-CoV-2 virus circulation: A model for vaccine development? (2021)

Although it remains difficult to compare the results directly, the potential for a strong reduction of transmission was shown, indicating that the animal models predicted what is observed in the field after large scale human vaccination. This merits further attention for standardization of exposure experiments, with the intention to speed up future vaccine development.