gebhart/patrepeval huggingface dataset:
An Integer Programming Approach for the 2-class Single-group Classification Problem (2019)

Two sets XB,XR⊆Rd are linearly separable if their convex hulls are disjoint, implying that a hyperplane separating XB from XR exists. Such a hyperplane provides a method for classifying new points, according to the side of the hyperplane in which the new points lie. In this work we consider a particular case of the 2-class classification problem, which asks to select the maximum number of points from XB and XR in such a way that the selected points are linearly separable. We present an integer programming formulation for this problem, explore valid inequalities for the associated polytope, and develop a cutting plane approach coupled with a lazy-constraints scheme.
Longitudinal Stent Deformation: Importance of Stent Type and Stent Apposition (2013)

Informat ion on stent longitudinal strength is limited to benchtop models using unconstrained stents, consequently having uncertain clinical significance. This study investigated the effects of stent apposition and tube (artery) compliance on stent stability. Multilin k Vision, Multilink 8, Pro mus Element, Driver and Integrity were examined. Stent size was 3/18 mm or closest length. Four scenarios were tested: in three the stents were well deployed and in the final test, stents were purposely severely malapposed. In the well-deployed models, three tubes with different co mpliance were tested. Stents were co mpressed by applying a single point force. Malapposed stents compressed extensively at 50 and 100 g m., especially Element, wh ich deformed double the amount of the other stents. At higher forces (150 g m.), the magnitude of difference was reduced. Stent apposition had a profound protective effect and limited differences between stents. Stiffer tubes provided more protection to stent deformation. A ll stents are vulnerable to deformation when severely malapposed but the Element is significantly more so. Well-apposed stents are considerably mo re resistant to longitudinal compression such that differences between stents become minimal. More rigid tubes offered greater protection. Clinical implications regarding stent sizing and postdilation strategy are significant.
Multi-factorial modulation of colorectal carcinoma cells motility - partial coordination by the tetraspanin Co-029/tspan8 (2017)

Colorectal carcinoma cells Isreco1 display an ability to migrate controlled by a complex set of signals issued from the membrane. By comparing cells infected by mycoplasmas and mycoplasmas free cells, we have established that basal 2D migration is dependent on a double signal mediated by the collagen receptors integrins alpha1/2 and the Toll-Like receptor TLR2. The signal issued from mycoplasmas can be replaced by a TLR2 ligand and the functional effect is neutralized by silencing of MyD88. Following previous observation that downregulation of E-cadherin/p120 catenin increases cell motility, we now report that EGFR or CD44 inhibition have a similar effect on cell motility that is restricted to tetraspanin Co-029/tspan8 transduced IsrecoI cells (Is1-Co029). The modulation of cell migration linked to EGFR or CD44 can be neutralized by antagonizing Co-029 with the mAb Ts29.1 or by RNA interference. Altogether these data point to a crucial role of Co-029 in the modulation of colon cancer cell motility which could be related to the protumoral effect reported for this tetraspanin. Among surface molecules able to mediate Co-029 function, E-cadherin, EGFR and CD44 appear as likely candidates.
Insulin, glucagon and the receptor-mediated control of cyclic AMP concentrations in liver (1986)

Conference Article| April 01 1986 Insulin, glucagon and the receptor-mediated control of cyclic AMP concentrations in liver MILES D. HOUSLAY MILES D. HOUSLAY 1Molecular Pharmacology Group, Department of Biochemistry, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K. Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Online ISSN: 1470-8752 Print ISSN: 0300-5127 © 1986 Biochemical Society1986 Biochem Soc Trans (1986) 14 (2): 183–193. https://doi.org/10.1042/bst0140183 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation MILES D. HOUSLAY; Insulin, glucagon and the receptor-mediated control of cyclic AMP concentrations in liver. Biochem Soc Trans 1 April 1986; 14 (2): 183–193. doi: https://doi.org/10.1042/bst0140183 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1986 Biochemical Society1986 Article PDF first page preview Close Modal You do not currently have access to this content.
Inhibition of the constitutive activity of human 5‐HT1A receptors by the inverse agonist, spiperone but not the neutral antagonist, WAY 100,635 (1997)

At recombinant human 5-hydroxytryptamine (5-HT)5-HT1A receptors expressed in Chinese hamster ovary cells (CHO-5-HT1A), 5-carboxamidotryptamine (5-CT), acted as a full agonist (relative to 5-HT = 100%) for stimulation of receptor-mediated [35S]-GTP gamma S (guanylyl 5'-[gamma-thio]-tryphosphate) binding. In contrast, spiperone inhibited basal [35S]-GTP gamma S binding by 30.2% (IC50 = 55.5 nM) in CHO-5-HT1A membranes but not in control untransfected membranes. The antagonist, N-[2-[4-(2-methoxyphenyl) -1-piperazinyl]ethyl]-N-(2-pyridinyl)-cyclohexane-carboxamide (WAY 100,635), blocked both 5-CT-induced stimulation and spiperone-induced inhibition of [35S]-GTP gamma S binding without itself modifying [35S]-GTP gamma S binding. It is concluded that, in this heterologous expression system, 5-HT1A receptors display 'constitutive' activation of G-proteins and that spiperone displays inverse agonist activity whereas WAY 100,635 acts as a 'neutral' antagonist at this site.
Highly Enantioselective, Base‐Free Synthesis of α‐Quaternary Succinimides through Catalytic Asymmetric Allylic Alkylation (2018)

The synthesis of diversely substituted five-membered ring succinimide derivatives is reported featuring a direct, base-free, palladium-catalyzed asymmetric allylic alkylation. The method allows a straightforward access to the desired heterocyclic scaffold bearing an all-carbon α-quaternary stereogenic center in high yields and good to excellent enantioselectivities. To further demonstrate the synthetic utility of the method, the allylated products were further converted to various versatile chiral building blocks, including a chiral pyrrolidine and a spirocyclic derivative, using selective transformations.
Design of Support Pillar Arrays in Flat Evacuated Windows (1991)

Flat evacuated glazing consists of two plane sheets of glass separated by a narrow evacuated space. These structures must incorporate an array of support pillars in order to maintain the separation of the glass plates under the influence of atmospheric pressure forces. A design procedure is outlined for determining the dimensions of this pillar array. Two important constraints in the design process are the mechanical tensile stress on the outside of the glass plates near the pillar, and the thermal conductance through the array of support pillars. A third constraint arises because of stress concentration near the pillars on the inside of the window. Evacuated windows having usefully low values of thermal conductance through the pillar array and tolerably small levels of exterior tensile stress can only be produced if large stresses exist on the inside of the structure in the region of the glass plates near the support pillars. The implications of these stresses are discussed. It is concluded that it is possible to design a pillar array for which the localised tensile stresses and overall thermal conductance have usefully small values.
Conclusions (2018)

This concluding chapter wraps up the main findings of the chapters, highlighting the linkage between China’s domestic policy process to address the climate-energy conundrum and Asian-Pacific energy exporters’ higher dependency on China and their moves toward a high CO2 emissions pathway. Then it presents possible ways to redirect the high CO2 emissions pathway as future challenges in research and in action.
Early decrease in hyaluronidase-sensitive cell surface charge during the differentiation of Friend erythroleukemic cells by dimethyl sulfoxide. (1979)

Early membrane events in erythroid differentiation were investigated by means of cell electrophoresis utilizing cultured Friend erythroleukemia cell clones of different inducibility. The cell electrophoretic mobility decreased by 18% within 30 min of treatment with 1.5% dimethyl sulfoxide (DMSO) in highly inducible clones but not in noninducible clones. The reduced mobility persisted for 5 days of incubation with DMSO until hemoglobin synthesis. DMSO treatment for less than 16 hr and subsequent incubation without the drug resulted in the complete recovery of the mobility and no hemoglobin synthesis. Longer exposure to DMSO resulted in the loss of recovery of mobility and an increasing fraction of benzidine-positive cells seen on Day 5. Measurement of the electrophoretic mobility after the removal of acidic sugars by their specific enzymes suggested that hyaluronidase-sensitive negative charges were lost from the cell surface only in highly inducible clones. The mobility reduction associated with hyaluronic acid was also caused by other potent inducers (sodium butyrate, N-methylacetamide, and N,N-dimethylacetamide). These results suggest that the decrease in cell surface glycocalyx might be an early step in the induction of differentiation of Friend erythroleukemia cells.
Effects of Acetyl-<i>DL</i>-Leucine in Vestibular Patients: A Clinical Study following Neurotomy and Labyrinthectomy (2008)

For 40 years, the amino acid acetyl-DL-leucine (or isoleucine - Tanganil) has been used in clinical practice to reduce imbalance and autonomic manifestations associated with acute vertigo crises. In animal models, acetyl-DL-leucine accelerates vestibular compensation following unilateral labyrinthectomy, and has only minor effects on normal vestibular function. Our work in animal models suggested that acetyl-DL-leucine acted mainly on abnormally hyperpolarized and/or depolarized vestibular neurons by restoring their membrane potential towards a mean value of -65 to -60 mV. Acute vestibular disorders are associated with asymmetrical spontaneous activities of vestibular neurons, so this previous study suggested that acetyl-DL-leucine may reduce acute, vestibular-related imbalances in humans. To test this hypothesis, we investigated the efficacy of acetyl-DL-leucine during the acute stage following neurotomy or labyrinthectomy in patients undergoing surgery for unilateral vestibular acoustic neurinoma, or suffering from unilateral and intractable Ménière's disease. By clinical testing of the vestibular function, patients were categorized according to the degree of compensation of the vestibular deafferentation prior to surgery. For patients who had achieved a close to perfect compensation before surgery, acetyl-DL-leucine had minor or no effect after surgery. For patients who displayed residual vestibular function before surgery, acetyl-DL-leucine eased the static vestibular syndromes, which followed neurotomy. Our findings tend to confirm the view that acetyl-DL-leucine mainly acts, in humans, on abnormally hyperpolarized and/or depolarized vestibular neurons by restoring their membrane potential towards normal values; this is consistent with findings in guinea pigs following unilateral labyrinthectomy. Moreover, it suggests that the degree of caloric paresis of the patients before neurotomy is useful both to predict the outcome of any acute vestibular syndrome following neurotomy and to assess the potential value of the administration of acetyl-DL-leucine to treat any such syndrome.
Effects of Environmental pH on Antioxidant Interactions between Rosmarinic Acid and α-Tocopherol in Oil-in-Water (O/W) Emulsions (2016)

Antioxidant regeneration could be influenced by various factors such as antioxidant locations and pH conditions. The effects of environmental pH on the antioxidant interaction between rosmarinic acid and α-tocopherol in oil-in-water (O/W) emulsions were investigated. Results showed that the combined antioxidants at pH 7 exhibited the strongest synergistic antioxidant activity in comparison with the combinations at other pH conditions as indicated by the interaction index. A drop in pH from 7 to 3 resulted in a reduction in the synergistic effect. However, in the case of pH 3, an additive effect was obtained. Moreover, the effect of the pH on the regeneration of α-tocopherol by rosmarinic acid in heterogeneous Tween 20 solutions was studied using EPR spectrometer. The same was true for the regeneration efficiency, where the reaction at pH 7 exhibited the highest regeneration efficiency of 0.3 mol of α-tocopheroxyl radicals reduced/mol of phenolics. However, the study on depletions of rosmarinic acid and α-tocopherol revealed that the formation of caffeic acid, an oxidative degradation product of rosmarinic acid, could be involved in enhancing the antioxidant activity observed at pH 7 rather than the antioxidant regeneration. This study has highlighted that the importance of pH-dependent antioxidant interactions does not solely rely on antioxidant regeneration. In addition, the formation of other oxidative products from an antioxidant should be taken into account.
Behavioral management of altered patterns of urinary elimination in women. (1996)

Urinary incontinence is a serious problem for many women. Nurses in a variety of settings can help women by thorough assessment, behavioral and environmental interventions, and appropriate referrals to urologic specialists.
Quantitative antigliadin antibody measurement in clinical practice: an Italian multicentre study. SIGEP Working Group on Quantitative AGA Standardization. (1999)

Antigliadin antibody concentration is not normally distributed and changes with age in non-coeliac subjects. The receiver operating characteristic analysis is a valuable tool for fixing the antigliadin antibody cut-offs between control and diseased individuals. The diagnosis of coeliac disease should always be confirmed by intestinal biopsy.
Astrocytes play an essential role in reversing respiratory disturbances in a mouse model of Rett syndrome (2010)

Recent in vitro studies have shown that astrocytes lacking methyl‐CpG‐binding protein 2 (Mecp2) have a non‐cell autonomous effect on neuronal properties such as dendrite arborization and morphology. Here we show that activation of Mecp2 in astrocytes of symptomatic null animals restores a normal breathing pattern. Mice carrying a loxP‐ stop cassette in intron 2 of the Mecp2 gene were crossbred to animals expressing a fusion protein of Cre DNA recombinase and a mutated estrogen receptor under the control of the human glial fibrillary acidic protein (GFAP) promoter. Male offspring are Mecp2 null, but the transcription factor can be restored in astrocytes by tamoxifen injections at any postnatal age. At P45 and older these mice developed apneas (~50/h) and an elevated irregularity score (&gt;0.4). Within 10 days of completing tamoxifen apnea declined, by 3 weeks it reached wild type levels and irregularity improved (~0.25). Immunohistochemistry showed co‐localization of Mecp2 in GFAP‐positive cells in the preBötzinger complex of tamoxifen‐treated mice. The results indicate the important role of astrocyte Mecp2 that functions to control neuronal network activity essential for normal respiration. Support: MOD &amp; IRSF (JB); DFG &amp; EC (FK); HHMI &amp; NIH (GM)
Stark-shift-chirped rapid-adiabatic-passage technique among three states (2005)

We show that the technique of Stark-chirped rapid adiabatic passage (SCRAP), hitherto used for complete population transfer between two quantum states, offers a simple and robust method for complete population transfer amongst three states in atoms and molecules. In this case SCRAP uses three laser pulses: a strong far-off-resonant pulse modifies the transition frequencies by inducing dynamic Stark shifts and thereby creating time-dependent level crossings amongst the three diabatic states, while near-resonant and moderately strong pump and Stokes pulses, appropriately offset in time, drive the population between the initial and final states via adiabatic passage. The population transfer efficiency is robust to variations in the intensities of the lasers, as long as these intensities are sufficiently large to enforce adiabatic evolution. With suitable pulse timings the population in the (possibly decaying) intermediate state can be minimized, as with stimulated Raman adiabatic passage (STIRAP). This technique applies to one-photon as well as multiphoton transitions and it is also applicable to media exhibiting inhomogeneous broadening; these features represent clear advantages over STIRAP by overcoming the inevitable dynamical Stark shifts that accompany multiphoton transitions as well as unwanted detunings, e.g., induced by Doppler shifts.
Clock-like Mutation Signature May Be Prognostic for Worse Survival Than Signatures of UV Damage in Cutaneous Melanoma (2023)

Novel treatment modalities comprising immune checkpoint inhibitors and targeted therapies have revolutionized treatment of metastatic melanoma. Still, some patients suffer from rapid progression and decease within months after a diagnosis of stage IV melanoma. We aimed to assess whether genomic alterations may predict survival after the development of stage IV disease, irrespective of received therapy. We analyzed tumor samples of 79 patients with stage IV melanoma using a custom next-generation gene-sequencing panel, MelArray, designed to detect alterations in 190 melanoma-relevant genes. We classified the patients: first, as short survivors (survival ≤6 months after stage IV disease, n = 22) and long survivors (survival >6 months, n = 57); second, by using a cut-off of one year; and third, by comparing the longest surviving 20 patients to the shortest surviving 20. Among analyzed genes, no individual gene alterations, or combinations of alterations, could be dichotomously associated with survival. However, the cohort's mutational profiles closely matched three known mutational signatures curated by the Catalog of Somatic Mutations in Cancer (COSMIC): UV signature COSMIC_7 (cosine-similarity 0.932), clock-like signature COSMIC_5 (cosine-similarity 0.829), and COSMIC_30 (cosine-similarity 0.726). Patients with UV signature had longer survival compared to patients with clock-like and COSMIC 30 (<i>p</i> < 0.0001). Subgroup dichotomization at 6 months showed that 75% of patients with UV signature survived longer than 6 months, and about 75% of patients with clock-like signature survived less than 6 months after development of stage IV disease. In our cohort, clock-like COSMIC_5 mutational signature predicted poor survival while a UV signature COSMIC_7 predicted longer survival. The prognostic value of mutational signatures should be evaluated in prospective studies.
Dihydroazulene Photoswitches: The First Synthetic Protocol for Functionalizing the Seven‐Membered Ring (2009)

Abstract The first synthetic protocol for functionalizing the dihydroazulene (DHA) photoswitch in its seven‐membered ring has been developed. This protocol is based on regioselective bromination, followed by regioselective elimination of HBr, and finally a palladium‐catalyzed cross‐coupling reaction with a terminal alkyne. The position of functionalization (C‐7) was confirmed by X‐ray crystal structure analysis. Light‐induced ring opening of this compound to its vinylheptafulvene (VHF) isomer followed by thermal ring closure provides a mixture of two DHA regioisomers in a ratio that depends on the wavelength of irradiation and solvent polarity.(© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2009)
Real-time team-mate AI in games (2010)

10.1145/1822348.1822365
Creativity and politics (1991)

The Cultural Revolution confirmed the close relation between artistic creation and political life, but also showed that variations in the relation were possible. Severe ideological attacks on particular writers and the complete reorganization of the cultural bureaucracy almost suffocated literary life. This chapter describes the political interference in literary life and the changes in the literary system. For political and ideological reasons, including those provided by the Shanghai Forum, the Cultural Revolution was hostile to literary creation. The ideological criticism of Wu Han and Teng T'o appeared to be a political instrument to eliminate the political enemies of Mao Tse-tung and Lin Piao. Because of internal dissent and external pressures, the Cultural Revolution Group never had the authority to give effective guidance to literary and artistic production and, except in the case of the promotion of modern Peking Opera on revolutionary themes, its interference in artistic life led nowhere.
Structures and Energetics of Four Adjacent G·U Pairs That Stabilize an RNA Helix (2015)

Consecutive G·U base pairs inside RNA helices can be destabilizing, while those at the ends of helices are thermodynamically stabilizing. To determine if this paradox could be explained by differences in base stacking, we determined the high-resolution (1.32 Å) crystal structure of (5'-GGUGGCUGUU-3')2 and studied three sequences with four consecutive terminal G·U pairs by NMR spectroscopy. In the crystal structure of (5'-GGUGGCUGUU-3')2, the helix is overwound but retains the overall features of A-form RNA. The penultimate base steps at each end of the helix have high base overlap and contribute to the unexpectedly favorable energetic contribution for the 5'-GU-3'/3'-UG-5' motif in this helix position. The balance of base stacking and helical twist contributes to the positional dependence of G·U pair stabilities. The energetic stabilities and similarity to A-form RNA helices suggest that consecutive G·U pairs would be recognized by RNA helix binding proteins, such as Dicer and Ago. Thus, these results will aid future searches for target sites of small RNAs in gene regulation.
A Percutaneous Knotless Technique for SLAP Repair (2016)

We describe a percutaneous technique for repair of type II SLAP lesions. Through the Neviaser portal, a spinal needle is used to pass a FiberStick suture (Arthrex, Naples, FL) through the labrum to create 2 mattress sutures that are secured with PushLock anchors (Arthrex). This technique is simple, reproducible, and knotless and requires no cannulas. At the end of the procedure, minimal suture material remains in the joint.
Characterization of the interleukin-17 isoforms and receptors in lesional psoriatic skin (2009)

This study characterizes the mRNA profile of the IL-17 isoforms and receptors in psoriatic skin lesions. Furthermore, we demonstrate for the first time augmented protein levels of IL-17A, IL-17C and IL-17F in psoriatic skin lesions, indicating a possible role for IL-17C in addition to IL-17A and IL-17F in the pathogenesis of psoriasis.