gebhart/patrepeval huggingface dataset:
Specific Training Effects of Concurrent Aerobic and Strength Exercises Depend on Recovery Duration (2015)

This study aimed to determine whether the duration (0, 6, or 24 hours) of recovery between strength and aerobic sequences influences the responses to a concurrent training program. Fifty-eight amateur rugby players were randomly assigned to control (CONT), concurrent training (C-0h, C-6h, or C-24h), or strength training (STR) groups during a 7-week training period. Two sessions of each quality were proposed each week with strength always performed before aerobic training. Neuromuscular and aerobic measurements were performed before and immediately after the overall training period. Data were assessed for practical significance using magnitude-based inference. Gains in maximal strength for bench press and half squat were lower in C-0h compared with that in C-6h, C-24h, and STR. The maximal voluntary contraction (MVC) during isokinetic knee extension at 60°·s(-1) was likely higher for C-24h compared with C-0h. Changes in MVC at 180°·s(-1) was likely higher in C-24h and STR than in C-0h and C-6h. Training-induced gains in isometric MVC for C-0h, C-6h, C-24h, and STR were unclear. V[Combining Dot Above]O2peak increased in C-0h, C-6h, and C-24h. Training-induced changes in V[Combining Dot Above]O2peak were higher in C-24h than in C-0h and C-6h. Our study emphasized that the interference on strength development depends on the recovery delay between the 2 sequences. Daily training without a recovery period between sessions (C-0h) and, to a lesser extent, training twice a day (C-6h), is not optimal for neuromuscular and aerobic improvements. Fitness coaches should avoid scheduling 2 contradictory qualities, with less than 6-hour recovery between them to obtain full adaptive responses to concurrent training.
CYTOCHROME‐C LOCALIZES IN SECRETORY GRANULES IN PANCREAS AND ANTERIOR PITUITARY (2001)

We used quantitative immunogold electron microscopy to evaluate the subcellular distribution of cytochrome-c in normal rat tissues, employing a wide variety of monoclonal and polyclonal antibodies against mammalian cytochrome-c. Immunogold labeling of tissues embedded in the acrylic resin LR Gold shows highly specific labeling of mitochondria in all tissues examined, including adrenal gland, cerebellum, cerebral cortex, heart, kidney, liver, pituitary, pancreas, skeletal muscle, spleen and thyroid. In pancreatic acinar cells and anterior pituitary, however, there was also strong cytochrome-c reactivity in zymogen granules and growth hormone granules, respectively. In the pancreas, strong immunoreactivity is also detected in condensing vacuoles and in the acinar lumen. Immunocytochemical controls included (i) use of monoclonal antibodies to horse cytochrome-c which recognize an epitope not present in rat cytochrome-c, (ii) preadsorption of antibodies with purified cytochrome-c, and (iii) omission of the primary antibody. The indicated presence of cytochrome-c outside mitochondria in certain tissues under normal physiological conditions raises interesting questions concerning translocation mechanisms and the cellular functions of cytochrome-c.
Hardware in the loop simulation for PIAGGIO MP3 control systems validation (2008)

Recently Piaggio developed a new scooter equipped with a revolutionary front suspension electronically controlled locking. It was critical to test and validate the design of this new control system before deployment to ensure high customer satisfaction and reducing warranty costs. Test on a HIL platform accelerates the verification and validation process. A validated HIL set-up, being a repeatable and reliable test platform with a short turnaround time is ideal for developing standardized processes for electronic control unit (ECU) testing and calibration. With shortening life cycles in the motorcycle industry, HIL technology is rapidly gaining acceptance not only in conventional vehicle programs, but also challenging vehicle programs. The development of control strategies for MP3 ECU has benefited from HIL-based testing. It has proven to be an efficient tool for software strategy development, implementation and validation. The goal of this paper is to demonstrate how the HIL simulation has been used during the validation phase of the new Piaggio scooter at ELASIS.
Direction-based text interpretation as an information access refinement (1992)

A Text-Based Intelligent System should provide more in-depth information about the contents of its corpus than does a standard information retrieval system, while at the same time avoiding the complexity and resource-consuming behavior of detailed text understanders. Instead of focusing on discovering documents that pertain to some topic of interest to the user, an approach is introduced based on the criterion of directionality (e.g., Is the agent in favor of, neutral, or opposed to the event?). A method is described for coercing sentence meanings into a metaphoric model such that the only semantic interpretation needed in order to determine the directionality of a sentence is done with respect to the model. This interpretation method is designed to be an integrated component of a hybrid information access system. 1 Introduction In the light of the increasing availability of computer-accessible full text, an important goal of a Text-Based Intelligent System is to provide a me...
Dark Classics in Chemical Neuroscience: Δ9-Tetrahydrocannabinol (2019)

Cannabis ( Cannabis sativa) is the most widely used illicit drug in the world, with an estimated 192 million users globally. The main psychoactive component of cannabis is (-)- trans-Δ<sup>9</sup>-tetrahydrocannabinol (Δ<sup>9</sup>-THC), a compound with a diverse range of pharmacological actions. The unique and distinctive intoxication caused by Δ<sup>9</sup>-THC primarily reflects partial agonist action at central cannabinoid type 1 (CB<sub>1</sub>) receptors. Δ<sup>9</sup>-THC is an approved therapeutic treatment for a range of conditions, including chronic pain, chemotherapy-induced nausea and vomiting, and multiple sclerosis, and is being investigated in indications such as anorexia nervosa, agitation in dementia, and Tourette's syndrome. It is available as a regulated pharmaceutical in products such as Marinol, Sativex, and Namisol as well as in an ever-increasing range of unregistered medicinal and recreational cannabis products. While cannabis is an ancient medicament, contemporary use is embroiled in legal, scientific, and social controversy, much of which relates to the potential hazards and benefits of Δ<sup>9</sup>-THC itself. Robust contemporary debate surrounds the therapeutic value of Δ<sup>9</sup>-THC in different diseases, its capacity to produce psychosis and cognitive impairment, and the addictive and "gateway" potential of the drug. This review will provide a profile of the chemistry, pharmacology, and therapeutic uses of Δ<sup>9</sup>-THC as well as the historical and societal import of this unique, distinctive, and ubiquitous psychoactive substance.
High performance open-loop AM modulator designed for power control of E-GPRS polar modulated power amplifier (2004)

An E-GPRS power amplifier controller, designed in a 5 V 0.5 /spl mu/m CMOS technology, is presented. Based on an open-loop polar modulation transmitter strategy for both GMSK in GSM and 8PSK in EDGE, the power control for both ramping and modulation depth is provided from collector supply control, and critical power amplifier (PA) temperature and process variability is compensated through the use of an automated bias calibration procedure detailed herein. Leveraging the architecture's capability for removal of transmit SAW filters, removal of isolators and maintenance of critical adjacent channel power ratio (ACPR) and error vector magnitude (EVM) performance into PA output mismatched impedance environments, the controller provides excellent linearity for higher power 8PSK power, and performance of transient spectrum due to switching even when run into the battery headroom limit of the supply rail.
Achieving efficiencies in care and support services (2007)

Housing with support and the efficiency agenda ‐ a toolkit has been published by Tribal Consulting as an aid to organisations involved in care and support provision that are faced with the need to find efficiencies. It is available as a free download from www.tribalgroup.co.uk/?ob=2&amp;id=386 or www.housingcorp.gov.uk . This article sets out the background to the Toolkit's development and the areas it covers.
Calcium Stones: The Difference Between Oxalate and Phosphate Types (1968)

No AccessJournal of Urology1 Nov 1968Calcium Stones: The Difference Between Oxalate and Phosphate Types James S. Elliot James S. ElliotJames S. Elliot More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)62599-0AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail © 1968 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byLavengood R and Marshall V (2018) The Prevention of Renal Phosphatic Calculi in the Presence of Infection by the Shorr RegimenJournal of Urology, VOL. 108, NO. 3, (368-371), Online publication date: 1-Sep-1972. Volume 100 Issue 5 November 1968 Page: 687-693 Advertisement Copyright & Permissions© 1968 by The American Urological Association Education and Research, Inc.Metrics Author Information James S. Elliot More articles by this author Expand All Advertisement PDF downloadLoading ...
Bulgaria: Economic Impacts of Exchange Rate Mechanism II and Banking Union Participation (2020)

The purpose of this article is to identify the benefits, costs, and risks of Bulgaria’s accession to the Exchange Rate Mechanism II and the European Banking Union. A descriptive approach is applied. The main findings are that there are costs and risks that are not thoroughly discussed or are underestimated implying that the net impact on Bulgaria’s economy is not definitely positive.
Vacuum assistance therapy as compared to early reconstructive treatment in deep sternal wound infection (2020)

Vacuum-assisted closure treatment induces an inferior outcome in terms of fungal infections, treatment times, and the number of reoperations.
MBIST Driven SRAM Failure Analysis Using Laser Voltage Imaging and Laser Voltage Probing (2019)

Abstract Static Random-Access Memory (SRAM) failure analysis (FA) is important during chip-level reliability evaluation and yield improvement. Single-bit, paired-bit, and quad-bit failures—whose defect should be at the failing bit-cell locations—can be directly sent for Physical Failure Analysis (PFA). For one or multiple row/column failures with too large of a suspected circuit area, more detailed fault isolation is required before PFA. Currently, Photon Emission Microscopy (PEM) is the most commonly used Electrical Failure Analysis (EFA) technique for this kind of fail [1]. Soft-Defect Localization / Dynamic Laser Stimulation (SDL/DLS) can also be applied on soft (Vmin) row/column fails for further isolation [2]. However, some failures do not have abnormal emission spots or DLS sensitivity and require different localization techniques. Laser Voltage Imaging (LVI) and Laser Voltage Probing (LVP) are widely established for logic EFA, [3] but require periodic activation via ATE which may not be possible using MBIST hardware and test-patterns optimized for fast production testing. This paper discusses the test setup challenges to enable LVI &amp; LVP on SRAM fails and includes two case studies on &amp;lt;14 nm advanced process silicon.
CLINICAL AND HISTOLOGICAL FACTORS ASSOCIATED WITH SENTINEL NODE IDENTIFICATION IN BREAST CANCER (2000)

Patients undergoing sentinel lymph node mapping and biopsy should be warned of the possibility of failure of sentinel node identification at operation. Our results suggest that the best predictor of intraoperative sentinel node identification is the visualization of the sentinel node on preoperative lymphoscintigraphy. The result of the lymhoscintigram may allow for additional preoperative counselling of the patient regarding the success or failure of sentinel node biopsy. Technical factors such as the experience and diligence of the surgeon, as well as the sentinel node mapping technique, are also important in determining the success of the procedure.
Motivating Learners in Multiorchestrator Mobile Edge Learning: A Stackelberg Game Approach (2022)

Mobile edge learning (MEL) is a learning paradigm that enables distributed training of machine learning (ML) models over heterogeneous edge devices (e.g., IoT devices). Multiorchestrator MEL refers to the coexistence of multiple learning tasks with different datasets, each of which being governed by an orchestrator to facilitate the distributed training process. In MEL, the training performance deteriorates without the availability of sufficient training data or computing resources. Therefore, it is crucial to motivate edge devices to become learners and offer their computing resources, and either offer their private data or receive the needed data from the orchestrator and participate in the training process of a learning task. In this work, we propose an incentive mechanism, where we formulate the orchestrators-learners’ interactions as a 2-round Stackelberg game to motivate the participation of the learners. In the first round, the learners decide which learning task to get engaged in, and then in the second round, the training parameters and the amount of data for training in case of participation such that their utility is maximized. We then study the training round analytically and derive the learners’ optimal strategy. Finally, numerical experiments have been conducted to evaluate the performance of the proposed incentive mechanism.
An Approach to Farm Management Information Systems Using Task-Specific, Collaborative Mobile Apps and Cloud Storage Services (2013)

<abstract> <bold>Abstract.</bold> Modern production agriculture is beginning to advance beyond deterministic, scheduled operations between relatively few people to larger scale, information-driven efficiency in order to respond to the challenges of field variability and meet the needs of a growing population. Since no two farms are the same with respect to information and management structure, a specialized farm management information system (FMIS) which is tailored to the realities on the ground of individual farms is likely to be more effective than generalized FMIS available today. This paper presents the design and implementation of a novel distributed set of open-source, collaborative mobile apps known as Open Ag Toolkit (OpenATK). OpenATK endeavors to provide such a specialized FMIS solution by incorporating low-cost, widely available mobile computing technologies, internet-based cloud storage services, and user-centered design principles.
Structural Modification of the Immunosuppressants FK-506 and Ascomycin Using a Biological Approach (1999)

Bioconversion was utilized to conduct structural modification of the complex molecules FK-506 and ascomycin. Four interesting microbial reactions, regiospecific O-demethylation, glucosylation, hydroxylation, and phosphorylation, yielding various derivatives of the title compounds, were discovered from screening more than thousand microorganisms including bacteria, actinomycetes, and fungi. The isolated compounds were evaluated for a better understanding of structural and functional features responsible for their biological activity.
Development of a Waterjet Propulsor for the Marine Corps High Water Speed Landing Craft Application (1992)

An advanced high performance waterjet propulsor was developed as part of the Marine Corps Surface Mobility technology development effort. Design optimization, performance estimating, and hydrodynamic design procedures are described for a propulsion unit required to meet specified thrust, power, and envelope characteristics. Testing of a 10-inch scale model and trials of the full scale propulsion units in both the HWSTD (High Water Speed Technology Demonstrator) and PSD (Propulsion System Demonstrator) developmental vehicles are described and performance data correlations presented.
Immunogenicity of N-Glycolylneuraminic Acid-Containing Carbohydrate Chains of Recombinant Human Erythropoietin Expressed in Chinese Hamster Ovary Cells (1995)

Recombinant human erythropoietin (EPO) produced by Chinese hamster ovary cells and distributed by two different pharmaceutical companies were confirmed to contain about 1% N-glycolylneuraminic acid (Neu5Gc) in total sialic acid content. Since chickens, like humans, do not synthesize Neu5Gc, they were used to determine the immunogenicity of Neu5Gc epitope in EPO. Chickens immunized with EPO did not produce significant titer of antibody that was specific to GM3(Neu5Gc) as compared to antibody titers produced in chickens immunized with fetuin containing 7% Neu5Gc or GM3(Neu5Gc) containing 100% Neu5Gc. Results obtained by an ELISA inhibition test showed that EPO, compared to GM3(Neu5Gc), reacted almost one thousand times less strongly with a human Hanganutziu-Deicher (HD) antibody. This study implies that an increase of Neu5Gc content in a molecule enhances its HD antigenicity. The response to Neu5Gc in patients receiving therapeutic injections of EPO is currently under investigation.
Characteristic analysis of a refractive axicon system for optical trepanning (2006)

An annular beam provides a new laser drilling mechanism, which we refer to as optical trepanning. A refractive axicon system has been designed to transform an input Gaussian laser beam into a collimated annular beam. The diffractive effects of the axicon system and a convex lens focusing the collimated annular beam have been studied using the Fresnel diffraction integral. The theoretical diffraction patterns are compared with the patterns measured with a laser-beam analyzer. The results show that the refractive axicon system can produce Gaussian-like annular beams with the capability of easily adjusting the size of the annular beam.
Space Interferometry Mission instrument mechanical layout (2002)

The Space Interferometry Mission, planned for launch in 2006, will measure the positions of celestial objects to an unprecedented accuracy of 4/spl times/10/sup -6/ are sec (about 1 billionth of a degree). In order to achieve this accuracy, which represents an improvement of almost two orders of magnitude over previous astrometric measurements, a ten-meter baseline interferometer will be flown in space. Starlight is collected by 33 cm diameter telescopes and combined to form fringes on detectors. To achieve the stated accuracy, the position of these fringes must be measured to a fraction of a wavelength of visible light. Passive vibration isolation and several layers of active control are used to stabilize the starlight wavefronts at sub-nanometer levels. Tight thermal control is coupled with very low CTE materials. Certain parts of the instrument need to be stabilized so that they move more slowly than the speed at which a baby grows.
Real life experience with check point and kinase inhibitors in Swiss advanced melanoma patients. (2015)

e20064 Background: Metastatic melanoma is an aggressive disease with a median survival in untreated Stage IV patients of only 6–9 months. Recent therapeutic developments in immunotherapy and targeted therapy have shown substantial improvement in response in metastatic melanoma. The current project intends to determine the benefit of the introduction of these new molecules in advanced melanoma across several regions of Switzerland. Methods: This is a retrospective multi-center analysisof 328 Swiss advanced melanoma patients treated with standard chemotherapy, checkpoint inhibitors (anti CTLA-4 or anti PD1 antibodies) and kinase inhibitors (Vemurafenib, Dabrafenib/Trametinib, Encorafenib and Binimetinib) either in first or second line setting from January 2008 until June 2013. Results: Median overall survival (mOS) from date of diagnosis of metastatic melanoma of all patients was 13.4 months. mOS of patients treated either with checkpoint or kinase inhibitors (n = 196, 17.1 months) between 2008-2013 was significantly prolonged (p < 0.001) compared to patients treated with standard chemotherapy within 2008-2009 (n = 88, 9.4 months). There was no significant difference in survival in BRAF mutated and wildtype patients (mOS 14.0 and 15.3 months, respectively, p = 0.84). 284 patients were further analyzed for survival in terms of treatments. One-year-survival was 71% (CI 60-79%) in 100 patients treated with ipilimumab, 55% (CI 45-65%) in 96 patients treated with targeted therapies and 37% (CI 27-48%) in 88 patients treated with standard chemotherapy. Proportion of patients surviving 2 years was 33% for patients treated with ipilimumab, 24% for patients with targeted therapy, and 14% in patients treated with chemotherapy. Conclusions: Treatments with check-point and kinase inhibitors beyond clinical trials significantly improve mOS and are consistent with published prospective data. Survival is independent from BRAF mutation status alone. National melanoma registries and cancer statistics are useful for monitoring outcomes of approved therapies or newly established treatment protocols across multiple institutions and patient populations.
Laparoscopic tubal ligation. A follow-up report on the Yoon falope ring methodology. (1979)

The Yoon Falope Ring methodology was examined on a prospective basis in 2299 patients from October 1973 through June 1978. The Yoon Falope Ring, made of medical-grade silicone rubber, can be applied by single- or double-puncture laparoscopy, by minilaparotomy, or transvaginally by either colpotomy or the culdoscopic technique. The patients were followed at 6-month intervals when possible. An overall follow-up rate of 75%, for a total of 37,140 woman-months, was achieved. The most significant complication was tubal transection; this occurred in 76 (3.3%) of cases during the study period. To date, the overall pregnancy failure rate, excluding luteal phase pregnancy, is 0.42% per 100 woman-years. As a laparoscopic methodology its versatility is well suited for outpatient, local anesthetic use. Although serosal bowel application was encountered in 2 early cases, it does not pose the same potential morbidity as does the bowel burn associated with electrocoagulation. A ring application to the serosal surface of the bowel can be removed laparoscopically, whereas a burn to the bowel requires laparotomy for probable resection and reanastomosis of the involved area. Intraand post-operative pain may be slightly higher than with electrocoagulation but is less than with the Pomeroy procedure. The advantages of the technique are multiple. It is a simple, safe, effective and easily learned methodology. It eliminates the morbidity and mortality associated with coagulation sterilization. When used in a training program, it is easily adaptable to a variety of surgical approaches.