gebhart/patrepeval huggingface dataset:
Software-Intensive Systems (2011)

Abstract : TERMS OF REFERENCE: (1) Review relevant DOD and government programs; (2) Review industry tools, practices, and standards (3) Identify potential benefits of best practices (4) Recommend changes in Naval acquisition management, systems engineering, training, education, and business practices; (5) Suggest ST (6) As appropriate, evaluate emerging tools for specifying, bidding, and engineering software-intensive systems and suggest strategies for use across multiple organizations.
Delayed treatment with combinations of antiviral drugs in mice infected with herpes simplex virus and application of the median effect method of analysis (1986)

Mice were inoculated intracerebrally with a lethal dose of herpes simplex virus type 2. Three days later, the mice were treated intraperitoneally, twice daily for 4 days, with the following drugs alone or in combination: acyclovir (ACV), vidarabine (ara-A), 2'-fluoro-5-iodoaracytosine (FIAC), and 2'-fluoro-5-methylarauracil (FMAU). Despite delayed treatment, most of the animals receiving low doses of FMAU alone or in combination with ACV or ara-A survived. In contrast, significantly higher mortality rates were noted in mice receiving ara-A, ACV, or FIAC alone. The data were analyzed for quantitation of synergism, additivity, and antagonism of multiple drug effect by the median effect method. The median effective doses (in nanomoles per kilogram per day) calculated in this manner were: FMAU, 22.5; FIAC, 510; ara-A, 901; ACV, 7,587; ACV-ara-A (drug ratio, 1:1), 550; FIAC-ara-A (1:1), 376; FIAC-ACV (1:1), 133; FMAU-ACV (1:8), 60.3; and FMAU-ara-A (1:8), 65.2. Marked synergy was found throughout a wide range of effect levels with the five different combinations, with no increased toxicity over the single-drug treatments. Similar results were obtained when the data were analyzed by the isobologram method. Since many patients with severe herpetic infections, such as herpes encephalitis, have a poor prognosis despite single-drug therapy, the possible use of combinations including low doses of FMAU deserves further investigation.
Serum thymidine kinase 1 is a prognostic and monitoring factor in patients with non-small cell lung cancer (2005)

Thymidine kinase 1 (TK1) is a pyrimidine metabolic pathway enzyme involved in salvage DNA synthesis and thus, a cell cycle-dependent marker. We have developed anti-TK1 monoclonal/polyclonal Abs raised against a 15-amino acid synthetic peptide (KPGEAVAARKLFAPQ) corresponding to part of the C-terminus of human TK1. These Abs are useful for both serological and immunohistochemical detection of TK1 in a number of cancer diseases. In this study we examined TK1 concentration in serum (STK1) in 250 preoperative non-small cell lung cancer patients (NSCLC), including 188 non-metastatic (group M0) and 62 metastatic patients (group M1). Serum from 16 healthy individuals was used as controls. The concentration of STK1 of preoperative NSCLC patients was significantly higher than STK1 of healthy individuals (p<0.0001). In group M0, preoperative STK1 concentration was significantly higher in patients of tumour size T2, as compared to tumour size T1 (p=0.042), and in T3-T4, as compared to T1-T2 (p=0.01). No significant difference in STK1 concentration between patients of tumour stage I and stage II (p=0.057) were found, but significantly higher STK1 concentration in patients of stage III, as compared stage I-II (p=0.025). No significant difference of STK1 concentration were found in patients of group M1 concerning tumour size or tumour stage, or between patients with adenocarcinomas (AC) and squamous cell carcinomas (SCC). We studied the changes of STK1 concentration individually one month after operation in metastatic subjects (group M1, n=19) and in tumour-free subjects (group M0, n=38). In the M0 group, the concentration of STK1 one month after operation was significantly decline by 45%, when comparing to concentrations of STK1 preoperative (p<0.001). In the group M1, however, no significant decrease in STK1 concentrations were found one month after operation. We conclude that STK1 has prognostic value and is a reliable marker for monitoring the response to surgery of NSCLC patients.
In vitro antimicrobial activity of a novel propolis formulation (Actichelated propolis) (2007)

This new formulation of propolis showing better antimicrobial and physical characteristics could improve the application of propolis in respiratory tract infections.
Melanoma Mediated Disruption of Brain Endothelial Barrier Integrity Is Not Prevented by the Inhibition of Matrix Metalloproteinases and Proteases (2022)

We have previously shown that human melanoma cells rapidly decrease human brain endothelial barrier strength. Our findings showed a fast mechanism of melanoma mediated barrier disruption, which was localised to the paracellular junctions of the brain endothelial cells. Melanoma cells are known to release molecules which cleave the surrounding matrix and allow traversal within and out of their metastatic niche. Enzymatic families, such as matrix metalloproteinases (MMPs) and proteases are heavily implicated in this process and their complex nature in vivo makes them an intriguing family to assess in melanoma metastasis. Herein, we assessed the expression of MMPs and other proteases in melanoma conditioned media. Our results showed evidence of a high expression of MMP-2, but not MMP-1, -3 or -9. Other proteases including Cathepsins D and B were also detected. Recombinant MMP-2 was added to the apical face of brain endothelial cells (hCMVECs), to measure the change in barrier integrity using biosensor technology. Surprisingly, this showed no decrease in barrier strength. The addition of potent MMP inhibitors (batimastat, marimastat, ONO4817) and other protease inhibitors (such as aprotinin, Pefabloc SC and bestatin) to the brain endothelial cells, in the presence of various melanoma lines, showed no reduction in the melanoma mediated barrier disruption. The inhibitors batimastat, Pefabloc SC, antipain and bestatin alone decreased the barrier strength. These results suggest that although some MMPs and proteases are released by melanoma cells, there is no direct evidence that they are substantially involved in the <b>initial</b> melanoma-mediated disruption of the brain endothelium.
Dynamic Operator Overload: A Model for Predicting Workload During Supervisory Control (2014)

Crandall <etal xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"/> and Cummings & Mitchell introduced fan-out as a measure of the maximum number of robots a single human operator can supervise in a given single-human-multiple-robot system. Fan-out is based on the time constraints imposed by limitations of the robots and of the supervisor, e.g., limitations in attention. Adapting their work, we introduced a dynamic model of operator overload that predicts failures in supervisory control in real time, based on fluctuations in time constraints and in the supervisor's allocation of attention, as assessed by eye fixations. Operator overload was assessed by damage incurred by unmanned aerial vehicles when they traversed hazard areas. The model generalized well to variants of the baseline task. We then incorporated the model into the system where it predicted in real time, when an operator would fail to prevent vehicle damage and alerted the operator to the threat at those times. These model-based adaptive cues reduced the damage rate by one-half relative to a control condition with no cues.
An Update to the Merchant Orthogonal Force Diagram (MFD) (2010)

Metal cutting as a science remains more art than science. A truly predictive model for use in quantitative modeling has eluded researchers to date, leading the noted mathematician, R. Hill [1] to observe that “it is notorious that the extant theories of the mechanics of machining do not agree well with experiment”. Extensive experiments with a videographic quick stop device (VQSD) by the author indicate an extremely simple reason for these disagreements. A simple correction that is applicable to all of the classic orthogonal models of metal cutting is presented. A detailed application to the classic Merchant Force Diagram is presented.
SAFE: A Neural Survival Analysis Model for Fraud Early Detection (2018)

Many online platforms have deployed anti-fraud systems to detect and prevent fraudulent activities. However, there is usually a gap between the time that a user commits a fraudulent action and the time that the user is suspended by the platform. How to detect fraudsters in time is a challenging problem. Most of the existing approaches adopt classifiers to predict fraudsters given their activity sequences along time. The main drawback of classification models is that the prediction results between consecutive timestamps are often inconsistent. In this paper, we propose a survival analysis based fraud early detection model, SAFE, which maps dynamic user activities to survival probabilities that are guaranteed to be monotonically decreasing along time. SAFE adopts recurrent neural network (RNN) to handle user activity sequences and directly outputs hazard values at each timestamp, and then, survival probability derived from hazard values is deployed to achieve consistent predictions. Because we only observe the user suspended time instead of the fraudulent activity time in the training data, we revise the loss function of the regular survival model to achieve fraud early detection. Experimental results on two real world datasets demonstrate that SAFE outperforms both the survival analysis model and recurrent neural network model alone as well as state-of-the-art fraud early detection approaches.
Augmentation of thyrotropin-induced iodide uptake in FRTL-5 cells by immunoglobulins containing blocking thyrotropin-receptor antibodies under NaCl-depleted conditions (1995)

We have found recently that Graves' immunoglobulins (Igs) are more active under NaCl-free conditions to increase iodide uptake in FRTL-5 thyroid cells. The present study was designed to examine the effect of blocking-type thyrotropin (TSH)-receptor antibodies (TR-abs) in the same assay. FRTL-5 cells were incubated with crude Ig fractions from 13 patients with primary hypothyroidism having blocking TR-abs and 100 mU/l bovine TSH in NaCl-free Hanks' balanced salt solution (HBSS) supplemented with 274 mmol/l sucrose (HBSS(-)-sucrose) to keep isotonicity for 3 days, followed by the determination of 60 min of 125I uptake in the cells. Thyrotropin alone increased the uptake to 3.3- to 5.2-fold of the basal. When the highest concentration (250 ml serum equivalent (eq.)/l) of the Ig was used, the TSH-stimulated 125I uptake was decreased to 0-42% in 11 of the 13 cases. When the lower concentrations (0.4-50 ml serum eq./l) were used, however, 125I uptake was enhanced (1.4- to 11.4-fold) unexpectedly in all 13 cases. Such an enhancement was specific to blocking TR-abs, because the effect was duplicated by the purified IgG but not by Igs from 10 healthy control subjects or from three TR-ab-negative hypothyroid patients. When Graves' Igs, instead of TSH, were used as a stimulator, the similar stimulatory effect of the Ig with blocking activity was observed on the 125I uptake induced by three Graves' Igs but not on the response to one Graves' Ig. These Igs alone displayed no stimulating activity. When isotonic 5H medium was used instead of HBSS(-)-sucrose, effects of these 13 Igs were only inhibitory on the TSH-stimulated 125I uptake.(ABSTRACT TRUNCATED AT 250 WORDS)
Intensity and Gain Measurements on the Stimulated Raman Emission in LiquidO2andN2 (1969)

In liquid ${\mathrm{O}}_{2}$ and ${\mathrm{N}}_{2}$ the threshold for stimulated Raman emission is found to be much lower than for other nonlinear processes. Thus it is possible to make reliable measurements of the intensity of Raman emission over a large range of incident laser power by using a simple longitudinal geometry. Several distinct regions of emission were investigated, including normal Raman scattering, exponential gain, onset of oscillation, and saturation. There is good agreement with theory.
Supplementary Table S3B: Copy Number change from Genomic and Immunological Tumor Profiling Identifies Targetable Pathways and Extensive CD8<sup>+</sup>/PDL1<sup>+</sup> Immune Infiltration in Inflammatory Breast Cancer Tumors (2023)

&lt;p&gt;Summary of copy number data.&lt;/p&gt;
Characterization of the human immunogiobulin ɛ mRNAs and their polyadenylation sites (1995)

Several IgE heavy (H) chain transcripts are produced by alternative splicing between constant region (CH3 and CH4) and membrane (M1 and M2) exons and by differential cleavage-polyadenylation at poly(A) sites downstream of the CH4 and M2 exons. We have now characterized the poly(A) signal of the epsilon transcripts that contain membrane exon sequences (epsilon CH4-M1'-M2, epsilon CH4-M1-M2, epsilon CH4-M2' and epsilon CH4-M2") and have determined the complete sequence of the M2 exon and 1.4 kb of downstream genomic DNA. The membrane locus poly(A) site was identified by RACE-PCR analysis of epsilon transcripts obtained from IgE-producing myeloma cells and normal peripheral blood lymphocytes (PBL). All membrane exon transcripts were found to be polyadenylated following a CA dinucleotide located 1046 nt from the beginning of the M2 exon. An AGTAAA hexamer, located 13 nt upstream from the site of cleavage and polyadenylation, was the only poly(A) signal sequence present in the 1.4 kb of genomic DNA downstream of the M2 exon. A (G+T)-rich region, which is also conserved in most poly(A) signals, was present 50 nt downstream of the AGTAAA hexamer. Northern blot analysis confirmed that this poly(A) site is used by the membrane exon epsilon mRNAs expressed by the U266 myeloma. The four membrane exon transcripts were detected in different relative amounts in PBL and IgE-producing myeloma cells, which could reflect different epsilon mRNA splicing patterns during B-cell differentiation.
Distributively controlling two robots handling an object in the task space without any communication (1996)

Two distributed cooperation controllers are presented for trajectory tracking of two manipulators which are cooperatively handling an object. The controllers control the positions of the robots distributively by using the trajectory error of the object in the task space. In the first controller, the internal force between the object and a manipulator is controlled only by a feedforward of the desired force. The second controller uses a force feedback. No communication is required between the manipulators in both the controllers. Their globally and exponentially asymptotic stabilities are guaranteed by Lyapunov functions.
Terapias avanzadas en enfermedades raras (2018)

Las terapias avanzadas comprenden un grupo de medicamentos biológicos basados en la terapia génica, la terapia celular y la ingeniería de tejidos. En este artículo se presentan algunos conceptos básicos, se describen las estrategias más prometedoras y se detallan los resultados de diferentes ensayos clínicos para un grupo significativo de enfermedades, especialmente las enfermedades hereditarias monogénicas. Se hace un mayor hincapié en la terapia génica ex vivo en enfermedades del sistema hematopoyético, al ser el grupo de enfermedades pioneras que además han orientado la investigación en el campo. Destacamos también algunos ejemplos de éxito de terapia génica in vivo y señalamos la contribución de la terapia celular y de la ingeniería de tejidos al grupo de enfermedades raras de la piel. Pretendemos con ello dar una visión de la situación de las terapias avanzadas en enfermedades raras y señalamos algunas de las vías de futuro orientadas al desarrollo de tratamientos más eficaces y seguros.
Reactivity Controlled Compression Ignition (RCCI) in a Single-Cylinder Air-Cooled HSDI Diesel Engine (2012)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;An experimental investigation of Reactivity Controlled Compression Ignition (RCCI) combustion was conducted in a small single-cylinder HSDI diesel generator engine and compared to standard Direct Injection (DI) diesel combustion to assess the validity of this combustion strategy for high efficiency operation and simultaneous NOx and soot emission reduction in cylinder for this type of engine. A Yanmar L70AE engine was modified from its unit injector mechanical fuel system to operate with a more flexible, electrically controlled common rail DI fuel system in order to achieve the high level of injection event control required for RCCI combustion.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;RCCI combustion was realized using split, early DI diesel fuel and Port Fuel Injected (PFI) gasoline for 25%, 50% and 75% engine loads (~3, 4.3 and 5.5 bar IMEPn). The effects of intake air temperature, DI injection timing and combustion phasing on engine efficiency, emissions and combustion stability were explored.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;The results indicated that RCCI combustion was effective at reducing NOx and soot emissions, but suffered from increased HC and CO emissions, and poor combustion efficiency at light loads, and higher levels of combustion variation compared to conventional diesel combustion. Thermal efficiency of RCCI combustion suffered at low loads due to poor combustion efficiency. At 75% load, RCCI attained nearly a 3% efficiency improvement over standard diesel combustion, indicating that there is significant opportunity to reduce light load fuel consumption with further optimization effort focused on combustion efficiency.&lt;/div&gt;&lt;/div&gt;
Synthesis and Evaluation of Blends Formed by Polymeric Crown Ethers and a Fullerene‐Containing Primary Ammonium Salt in Organic Thin Films (2007)

Abstract The synthesis of a series of polymers and cyclopolymers bearing crown ethers of differing structure and affinities towards primary ammonium ions is discussed. These polymers have been tested in their efficiency to form structurally homogeneous thin films when blended with an amphiphilic C60 compound containing a primary ammonium ion functional group. The X‐ray reflectivity characterization of the films revealed that the polymer bearing the crown ether with the least affinity for primary ammonium ions, but having the highest degree of polymerization, is the most effective in forming structurally homogeneous thin films.
Grafting and Polymer Formation on Silicon from Unsaturated Grignards:  I− Aromatic Precursors (2006)

Anodic decomposition of a phenylmagnesium halide at a surface-hydrogenated silicon electrode leads to formation of polymeric layers covalently anchored to the silicon surface. These layers have been characterized using spectroellipsometry, photoluminescence, infrared, and X-ray photoelectron spectroscopies. The phenyl ring appears preserved in the process, and the polymer formed is a polyphenylene. Contamination by aliphatic groups from the solvent may be minimized by using a solvent resistant to hydrogen abstraction by the phenyl radicals. Regioselectivity of the branching may be oriented to the para form by using 4-chlorophenylmagnesium bromide as the precursor.
Learning to learn with the informative vector machine (2004)

This paper describes an efficient method for learning the parameters of a Gaussian process (GP). The parameters are learned from multiple tasks which are assumed to have been drawn independently from the same GP prior. An efficient algorithm is obtained by extending the informative vector machine (IVM) algorithm to handle the multi-task learning case. The multi-task IVM (MTIVM) saves computation by greedily selecting the most informative examples from the separate tasks. The MT-IVM is also shown to be more efficient than random sub-sampling on an artificial data-set and more effective than the traditional IVM in a speaker dependent phoneme recognition task.
Reversible Control of Pitch of Induced Cholesteric Liquid Crystal by Optically Active Photochromic Fulgide Derivatives (1997)

Abstract Mixtures of nematic 4-cyano-4′-pentylbiphenyl and (R)-2,2′-dihydroxy-1,1′-binaphthyl-condensed fulgide derivatives form stable cholesteric liquid crystalline states. Photochromic reactions of them induced the change of their cholesteric pitch reversibly.
Oxidized LDL-Induced Apoptosis (2006)

There is now substantial evidence establishing that oxLDL and lipid peroxidation products generated in the vascular wall, can elicit proinflammatory and pathological events involved in atherosclerosis. As reported by D. Hajjar and M. Haberland, the oxLDL should be considered as true molecular “Trojan Horses” or “cellular saboteurs” bearing a lot of bioreactive products of lipid peroxidation, that modify cell functions, induce intracellular oxidative stress, trigger multiple and contradictatory cell signalings and transcription factors, and finally induce cell death by apoptosis or necrosis. To date, the signaling mechanisms triggered by oxLDL and leading to physiopathological events, are only partly understood. The oxLDL-mediated apoptosis may participate in the progression of atherosclerosis, and in subsequent plaque rupture and thrombotic events which lead finally to acute cardiovascular diseases. In cultured cells antioxidants inhibit LDL oxidation and biological effect of oxLDL, such as apoptosis induction, but their ability to prevent efficiently vascular diseases and to induce regression of established lesions remains to be established. In conclusion, it is very important to clarify the mechanisms of cell-mediated LDL oxidation, as well as the cellular dysfunctions induced by lipid peroxidation products, in order to define new therapeutic strategies efficient in blocking and preventing the atherosclerotic process which always represent a major cause of death in western countries.
Progestins inhibit the growth of MDA-MB-231 cells transfected with progesterone receptor complementary DNA. (1999)

Because progesterone exerts its effects mainly via estrogen-dependent progesterone receptor (PgR), the expression of progesterone's effects may be overshadowed by the priming effect of estrogen. PgR expression vectors were transfected into estrogen receptor (ER)-alpha and PgR-negative breast cancer cells MDA-MB-231; thus the functions of progesterone could be studied independent of estrogens and ERs. Eight stable transfectant clones expressing both PgR isoform A and B were studied for their growth response to progesterone and its analogues. Although progesterone had no effect on growth in the control transfectant, the hormone markedly inhibited DNA synthesis and cell growth in all of the PgR-transfectants dose-dependently from 10(-12)-10(-6) M. This growth inhibition was associated with an arrest of cells in the G0/G1 phase of the cell cycle. Progestins medroxyprogesterone acetate, Org2058, and R5020 also strongly inhibited DNA synthesis, and their doses required for maximal inhibition of 60-70% were 10(-17) M, 10(-13) M, and 10(-7) M, respectively. Antiprogestin ZK98299 alone had no effect, but the compound was capable of counteracting the inhibitory effect of progesterone. In contrast, RU486 inhibited DNA synthesis, and it showed no further effects when it was used concurrently with progesterone. These results indicate that progestins are per se antiproliferative via a PgR-mediated mechanism in breast cancer cells. More importantly, we have shown that progestins may exert effective inhibitory control over the cell growth if the PgR expression is reactivated in ER- and PgR-negative breast cancer cells.