gebhart/patrepeval huggingface dataset:
Phosphatases as targets for cancer treatment. (2009)

Although protein kinases are the molecular targets for an increasing number of anticancer agents, there is a notable absence of drugs targeting protein phosphatases, the biochemical counterpart of the protein kinases. This absence is particularly striking because many cancer-relevant pathways are also controlled by protein phosphatases, which can function abnormally in human tumors. Several research groups are searching for drug-like inhibitors of phosphatase-based cancer targets. This review examines several protein phosphatases for which investigational anticancer agents have been identified and are being investigated.
Supporting concurrent applications in wireless sensor networks (2006)

It is vital to support concurrent applications sharing a wireless sensor network in order to reduce the deployment and administrative costs, thus increasing the usability and efficiency of the network. We describe Melete 1 , a system that supports concurrent applications with efficiency, reliability, flexibility, programmability, and scalability. Our work is based on the Maté virtual machine [1] with significant modifications and enhancements. Melete enables reliable storage and execution of concurrent applications on a single sensor node. Dynamic grouping is used for flexible, on-the-fly deployment of applications based on contemporary status of the sensor nodes. The grouping procedure itself is programmed with the TinyScript language. A group-keyed code dissemination mechanism is also developed for reliable and efficient code distribution among sensor nodes. Both analytical and simulation results are presented to study the impact of several key parameters and optimization techniques on the code dissemination mechanism. Simulation results indicate satisfactory scalability of our techniques to both application code size and node density. The usefulness and effectiveness of Melete is also validated by empirical study.
Decreasing Colectomy Rates for Ulcerative Colitis: A Population-Based Time Trend Study (2012)

From 1997 to 2009, use of purine anti-metabolites increased and elective colectomy rates in UC patients decreased significantly. In contrast, emergent colectomy rates were stable, which may have been due to rapid progression of disease activity.
The Influenza A Virus Genotype Determines the Antiviral Function of NF-κB (2016)

This study addresses two different issues. First, we investigated the role of the host cell transcription factor NF-κB in IAV replication by genetic manipulation of IAVs by reverse genetics combined with targeted genome engineering of host cells using CRISPR-Cas9. The analysis of these two highly defined genetic systems indicated that the IAV genotype can influence whether NF-κB displays an antiviral function and thus might in part explain incoherent results from the literature. Second, we found that perturbation of NF-κB function greatly improved the growth of a nonadapted IAV, suggesting that NF-κB may contribute to the maintenance of the host species barrier.
Scaleable retrograde p-well CMOS technology (1981)

The retrograde p-well CMOS technology utilizes a single high-energy boron implant to produce a self-aligned channel stop and an extremely shallow, low sheet-resistance p-well while maintaining controllable, low n-channel threshold voltages. Conventional CMOS technologies are limited by Gaussian profiles where surface concentration, sheet resistance, and junction depth are directly coupled and low threshold voltages require either deep junctions or high sheet resistance. The retrograde p-well peak charge resides 1µ below the surface which lowers npn-beta from conventional values of 500-1000 to 30- 50 and allows spacing between n- and p-channel devices to be reduced from 12-15µ to 3-6µ. This all-implanted CMOS technology has been developed, fully characterized and modeled for devices with electrical channel lengths below 2µ. Ring oscillators have, a 700psec. stage delay and a 1K RAM test structure shows a 3.7 times density improvement, lower latch-up susceptibility, lower defect density, and higher performance than the same RAM conventionally processed.
Recherches sur l'architecture des expositions universelles et leur emprise sur l'image urbaine : l'exposition universelle de 1878, une somme architecturale devant le monde moderne (1987)

L'architecture de l'exposition universelle de 1878, projetee ou realisee pour cette occasion, tel est le sujet de notre these. Chaque batiment, pour autant que les archives, les collections et les publications de l'epoque nous le permettent, a fait l'objet d'une restitution, une sorte de description raisonnee. Une etude approfondie considere ensuite ces constructions - palais et pavillons - dans le contexte, plus general, de l'histoire des expositions universelles et l'histoire de l'architecture. Ce travail apporte la preuve que l'architecture des expositions universelles nous offre une forme de catalogue grandeur nature de l'industrie du batiment, car les differents edifices, du plus grand au plus petit, constituent autant des echantillons que des surfaces d'exposition au meme titre que les vitrines! presque toutes les techniques, les metiers d'art et les professions qui inter- viennent dans le domaine de l'architecture sont representes. Cette monographie peut apporter par consequent deux aspects aussi essentiels que nouveaux a notre discipline. D'une part elle permet de confronter au discours et aux revendications doctrinales et esthetiques des architectes un portrait beaucoup plus detaille de l'ensemble de ce milieu socio-professionnel et d'autre part elle esquisse la richesse ( sur le plan de la creation comme de la production) d'une epoque generalement consideree comme mineure en comparaison au second-empire et aux dernieres annees du xixeme siecle. Elle elargit ainsi le champ de perception de l'histoire de l'architecture en lui apportant de nouvelles perspectives qui completent les considerations d'ordre typologique ou stylistique.
Electrically driven spin excitation in the ferroelectric magnetDyMnO3 (2008)

Temperature (5--250 K) and magnetic-field (0--70 kOe) variations of the low-energy (1--10 meV) electrodynamics of spin excitations have been investigated for a complete set of light-polarization configurations for a ferroelectric magnet ${\text{DyMnO}}_{3}$ by using terahertz time-domain spectroscopy. We identify the pronounced absorption continuum (1--8 meV) with a peak feature around 2 meV, which is electric-dipole active only for the light $E$ vector along the $a$ axis. This absorption band grows in intensity with lowering temperature from the spin-collinear paraelectric phase above the ferroelectric transition but is independent of the orientation of spiral spin plane ($bc$ or $ab$), as shown on the original ${P}_{\text{s}}$ (ferroelectric polarization) $\ensuremath{\parallel}c$ phase as well as the magnetic-field induced ${P}_{\text{s}}\ensuremath{\parallel}a$ phase. The possible origin of this electric-dipole active band is argued in terms of the large fluctuations of spins and spin current.
Mobile CARS Instrument for combustion and plasma diagnostics (1985)

A mobile CARS system for combustion and plasma diagnostics is described. The instrument is compact, easily transportable, readily adaptable to a wide variety of laboratories and experiments, capable of withstanding high noise and vibration levels, and remotely operable to protect the operator and delicate components from high noise or hazardous environments.
Data Location Verification in Cloud Computing (2013)

Cloud computing has pioneered the area of On-demand services. The customer can choose the resources according to the current needs with the facility of incrementing and decrementing the resources in the future. It generally follows a pay-as-you-use model which has proven beneficial for enterprises and individual users alike. Since the services are hosted over the internet, one of the recent concerns that are rising among the users is about the location of their data. Sometimes it is necessary for the data to stay in a particular jurisdiction. Therefore, it may be required for the organization to verify the location of their data from time to time. Here in this paper we propose a mechanism based on remote attestation technology of trusted platform module. Remote attestation technique is used to validate the current location of the data, and the generated result is passed to the user/verifier. The very fact that the trusted platform module is tamper proof provides the basis for the accuracy of the result.
LDL Apheresis for Cholesterol Embolism Following Coronary Artery Bypass Graft Surgery (2006)

A 76-year-old man without any prior history of abnormal urinalysis findings or renal insufficiency demonstrated mild renal dysfunction after coronary bypass graft surgery (CABG). Two months after CABG, pain and blueness in the toes (blue toe syndrome) appeared and, the serum creatinine level (S-Cr) increased from 1.2 to 2.0 mg/dL. On admission (3 months later), the urinary protein level was 0.5 g/day, white blood cell count 8,300/microL with eosinophils (Eo) 10.5%, S-Cr 2.1 mg/dL, and low-density lipoprotein (LDL) 106 mg/dL. Acute renal failure and blue toe syndrome due to a cholesterol embolism (CE) were diagnosed. Alprostadil 40 microg/day orally for 2 weeks and alprostadil 40 microg/day intravenously were used for 5 weeks, and Eo were 250/microL, S-Cr 2.5 mg/dL; however, blue toe syndrome gradually developed. At 8 weeks after admission, limaprost alfadex 30 microg/day orally was used for 3 weeks. However, the Eo gradually rose to 1,520/microL, S-Cr to 3.0 mg/dL, and LDL to 135 mg/dL, and LDL apheresis was therefore performed 20 times for CE. The data just after LDL apheresis was performed 10 times were as follows: Eo 1,120/microL, S-Cr 4.0 mg/dL, and LDL 89 mg/dL, and blue toe syndrome had disappeared. At 10 months after the first LDL apheresis, the Eo were 630/microL, S-Cr 2.9 mg/dL, and LDL 109 mg/dL. As a result, LDL apheresis was found to be beneficial for the treatment of CE with acute renal failure and blue toe syndrome after CABG.
Image based deformable mirror control for adaptive optics in satellite telescope (2012)

We are developing an adaptive optics system for earth observing remote sensing sensor. In this system, high spatial
resolution has to be achieved by a lightweight sensor system due to the launcher’s requirements. Moreover, simple
hardware architecture has to be selected to achieve high reliability. Image based AOS realize these requirements without
wavefront sensor. In remote sensing, it is difficult to use a reference point source unless the satellite controls its attitude
toward a star or it has a reference point source in itself. We propose the control algorithm of the deformable mirror on
the basis of the extended scene instead of the point source. In our AOS, a cost function is defined using acquired images
on the basis of the contrast in spatial or Fourier domain. The cost function is optimized varying the input signal of each
actuator of the deformable mirror. In our system, the deformable mirror has 140 actuators. We use basis functions to
reduce the number of the input parameters to realize real-time control. We constructed the AOS for laboratory test, and
proved that the modulated wavefront by DM almost consists with the ideal one by directly measured using a Shack-
Hartmann wavefront sensor as a reference.
Polynominterpolation (1994)

ZusammenfassungPolynominterpolation ist die grundlegende aller Interpolationsmethoden; die früheste Methode geht wahrscheinlich auf I. Newton zurück. Heutzutage ist Polynominterpolation mehr von theoretischer Bedeutung; es sind schnellere und genauere Methoden bekannt. Diese Methoden sind stückweise polynomial; somit basieren sie auf den Polynommethoden, die in diesem Kapitel vorgestellt werden.
Creation of “Rose Petal” and “Lotus Leaf” Effects on Alumina by Surface Functionalization and Metal‐Ion Coordination (2017)

Abstract Functional differences between superhydrophobic surfaces, such as lotus leaf and rose petals, are due to the subtle architectural features created by nature. Mimicry of these surfaces with synthetic molecules continues to be fascinating as well as challenging. Herein, we demonstrate how inherently hydrophilic alumina surface can be modified to give two distinct superhydrophobic behaviors. Functionalization of alumina with an organic ligand resulted in a rose‐petal‐like surface (water pinning) with a contact angle of 145° and a high contact angle hysteresis (±69°). Subsequent interaction of the ligand with Zn 2+ resulted in a lotus‐leaf‐like surface with water rolling behavior owing to high contact angle (165°) and low‐contact‐angle‐hysteresis (±2°). In both cases, coating of an aromatic bis‐aldehyde with alkoxy chain substituents was necessary to emulate the nanowaxy cuticular feature of natural superhydrophobic materials.
An In Vitro Evaluation of Botanical Compounds for the Control of the Honeybee PathogensBacillus larvaeandAscosphaera apis, and the Secondary InvaderB. alvei (1994)

ABSTRACT Bactericidal and fungicidal effects of eight plant extracts on the growth of two honeybee pathogens, Bacillus larvae (causative agent of American foulbrood) and Ascosphaera apis (causative agent of chalkbrood), and Bacillus alvei (a secondary invader in European foulbrood), were evaluated. Cinnamon oil completely inhibited the growth of B. larvae at 10 ppm for 72 h. Camphor and citronellal inhibited all growth at 100 ppm for 72 h. Bay oil, clove oil, origanum oil, and thymol inhibited all growth at 1,000 ppm for 72 h, and α-terpinene inhibited all growth at 10,000 ppm for 72 h. Cinnamon oil completely inhibited the growth of A. apis at 100 ppm for 168 h. Bay oil, citronellal, clove oil, origanum oil and thymol inhibited all growth at 1,000 ppm for 168 h. Camphor inhibited all growth at 10,000 ppm for 168 h, and α-terpinene inhibited all growth for 72 h at 10,000 ppm. Cinnamon oil and thymol completely inhibited the growth of B. alvei at 10 ppm for 72 h. Bay oil, camphor and origanum oil inhibited all growth at 100 ppm for 72 h. Clove oil and citronellal inhibited all growth at 1,000 ppm for 72 h, and α-terpinene inhibited growth at 10,000 ppm for 72 h. Several compounds reduced growth in a dose dependent manner at levels below their threshold values. These results suggest that plant extracts might play a significant role in the management of honeybee diseases.
Temperature-Corrected Model of Turbulence in Hot Jet Flows (2007)

An improved correction has been developed to increase the accuracy with which certain formulations of computational fluid dynamics predict mixing in shear layers of hot jet flows. The CFD formulations in question are those derived from the Reynolds-averaged Navier-Stokes equations closed by means of a two-equation model of turbulence, known as the k-epsilon model, wherein effects of turbulence are summarized by means of an eddy viscosity. The need for a correction arises because it is well known among specialists in CFD that two-equation turbulence models, which were developed and calibrated for room-temperature, low Mach-number, plane-mixing-layer flows, underpredict mixing in shear layers of hot jet flows. The present correction represents an attempt to account for increased mixing that takes place in jet flows characterized by high gradients of total temperature. This correction also incorporates a commonly accepted, previously developed correction for the effect of compressibility on mixing.
Immunohistochemical evidence of urokinase-type plasminogen activator in primary and metastatic tumors of pulmonary adenocarcinoma. (1991)

The urokinase-type plasminogen activator (u-PA) was used to study 96 cases of lung adenocarcinoma and 49 cases of lymph node metastatic adenocarcinoma. We made use of the immunohistochemistry of paraffinized samples. u-PA was detected in the cytoplasm of tumor cells, and the number of positive cells was higher in patients with T2 or T3 than in those with T1 disease (P less than 0.01). These u-PA-positive tumor cells were more frequent in patients with N2 than in those with N1 disease (P less than 0.01). Such cells were also detected in patients with N1 rather than N0 disease (P less than 0.01). When we compared the frequency of u-PA-positive tumor cells in metastatic lesions with that in primary ones, the former tended to be higher. On the other hand, the frequency of u-PA-positive cells in primary tumors of patients with a recurrence was higher than in those with no recurrence. Thus, u-PA is an important prognostic indicator associated with tumor growth and lymph node spread. If u-PA is detected in a tumor, a recurrence can be expected.
Protein markers of dysfunctional HDL in scavenger receptor class B type I deficient mice (2018)

SR-BI deficiency leading to dysfunctional HDL is closely related to alteration of HDL protein, suggesting that identification of apoAI, PON1, SAA, apoAIV, and A1AT may serve as the valuable protein markers for diagnosis and therapeutics of dysfunctional HDL-related metabolic diseases.
Single Event Upsets in Deep-Submicrometer Technologies Due to Charge Sharing (2008)

Circuit and 3D technology computer aided design mixed-mode simulations show that the single event upset vulnerability of 130- and 90-nm hardened latches to low linear energy transfer (LET) particles is due to charge sharing between multiple nodes as a result of a single ion strike. The low LET vulnerability of the hardened latches is verified experimentally.
Influence of basement structures on in situ stresses over the Surat Basin, southeast Queensland (2015)

Abstract The Jurassic to Cretaceous sedimentary rocks of the Surat Basin in southeast Queensland host a significant volume of coal seam gas resources. Consequently, knowledge of the in situ stress is important for coal permeability enhancement and wellbore stability. Using wireline log data and direct stress measurements, we have calculated stress orientations from 36 wells and stress magnitudes from 7 wells across the Surat Basin. Our results reveal a relationship between high tectonic stress and proximity to structures within the underlying “basement” rocks. The influence of tectonic stresses is diminished with depth in areas with thicker sedimentary cover that are relatively far from the basement structures. We suggest that this relationship is due to the redistribution of in situ stresses around areas where basement is shallower and where basement structures, such as the Leichhardt‐Burunga Fault System, are present. This behavior is explained by a lower rigidity in the thickest basin cover, which reduces the ability to maintain higher tectonic stress. Over the entire Surat Basin, a significant amount of variability in in situ stress orientation is observed. The authors attribute this stress variability to complex plate boundary interactions on the northern and eastern margins of the Indo‐Australian Plate.
TAS3 miR390-dependent loci in non-vascular land plants: Towards a comprehensive reconstruction of the gene evolutionary history (2018)

Trans-acting small interfering RNAs (ta-siRNAs) are transcribed from protein non-coding genomic loci and belong to a plant-specific class of endogenous small RNAs. These siRNAs have been found to regulate gene expression in most taxa including seed plants, gymnosperms, ferns and mosses. In this study, bioinformatic and experimental PCR-based approaches were used as tools to analyze TAS3 and TAS6 loci in transcriptomes and genomic DNAs from representatives of evolutionary distant Bryophyta, Marchantiophyta and Anthocerotophyta. We revealed previously undiscovered TAS3 loci in classes Sphagnopsida and Anthocerotopsida, as well as TAS6 loci in Bryophyta classes Tetraphidiopsida, Polytrichopsida, Andreaeopsida and Takakiopsida. These data further unveil the evolutionary pathway of the miR390-dependent TAS3 loci in land plants. We also identified SGS3-coding sequences in charophytes and hypothesized that the appearance of TAS3-related sequences could take place at a very early step in evolutionary transition from charophyte algae to an earliest common ancestor of land plants.
Junio de 1988, Buenos Aires (2003)

invencin, o sea, el comprom iso con su sociedad entera, y contribuir a su m odificacin por m edio del lenguaje.
Deformation measurement with object-induced dynamic phase shifting (1996)

A simple, yet powerful, means of computing the phase of fringe patterns depicting dynamic phenomena is presented. It is shown that the basic principle of the phase-shifting methods can be extended to the case of dynamic situations. The crux is to recognize that the phenomenon under examination can itself provide the necessary incremental phase shifts. This new method possesses a very wide range of applications in the field of deformation measurement.
ChemInform Abstract: A Versatile Synthesis of Annulated Carbazole Analogues Involving a Domino Reaction of Bromomethylindoles with Arenes/Heteroarenes. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Joint Physical Layer Coding and Network Coding for Bi-Directional Relaying (2008)

We consider the problem of two transmitters wishing to exchange information through a relay in the middle. The channels between the transmitters and the relay are assumed to be synchronized, average power constrained additive white Gaussian noise channels with a real input with signal-to-noise ratio (SNR) of snr. An upper bound on the capacity is 1/2 log(1+ snr) bits per transmitter per use of the medium-access phase and broadcast phase of the bi-directional relay channel. We show that using lattice codes and lattice decoding, we can obtain a rate of 1/2 log(0.5 + snr) bits per transmitter, which is essentially optimal at high SNRs. The main idea is to decode the sum of the codewords modulo a lattice at the relay followed by a broadcast phase which performs Slepian-Wolf coding with structured codes. For asymptotically low SNR's, jointly decoding the two transmissions at the relay (MAC channel) is shown to be optimal. We also show that if the two transmitters use identical lattices with minimum angle decoding, we can achieve the same rate of 1/2 log(0.5 + snr). The proposed scheme can be thought of as a joint physical layer, network layer code which outperforms other recently proposed analog network coding schemes.
Expression of Glial Fibrillary Acidic Protein, Vimentin, Fibronectin, and N-myc Oncoprotein in Primary Human Brain Tumor Cell Explants (1991)

Cultured cells of explants from 23 human gliomas (seven astrocytomas, eleven anaplastic astrocytomas, three ependymal tumors and two medulloblastomas) were studied to examine cell morphology and expression of glial fibrillary acidic protein (GFAP), vimentin, fibronectin, and N-myc oncoprotein. The most common antigenic phenotype consisted of cells that were GFAP-positive and fibronectin-positive. Both low and high grade astrocytomas retained GFAP expression after several passages in vitro. The establishment of glial tumors in vitro may not necessarily result in loss of GFAP expression early in passage nor is expression of GFAP and fibronectin mutually exclusive. N-myc oncoprotein was seen in only two specimens, one anaplastic astrocytoma and one ependymoma.