gebhart/patrepeval huggingface dataset:
The effects of cyclodextrins on drug release from fatty suppository bases : II. In vivo observations (1991)

The effects of cyclodextrin complexation on the absorption of drugs from fatty suppositories was evaluated in human volunteers. Three model drugs: diazepam, ibuprofen and prednisolone were used. When diazepam was complexed with γ-cyclcodextrin the drug release from the fatty suppositories was changed as compared with suppositories containing pure drug. After melting and spreading, the lipid insoluble complex particles dissolved in the aqueous rectal fluid. As a result of dilution and displacement of the drug from the complex by endogenous lipids, the dissolved complex dissociated. Approximately 25% of the free drug was absorbed fairly rapidly. Due to the high o/w partition coefficient of diazepam, a significant amount of the free drug in the rectal fluid diffused back into the lipid suppository base. The absorption of this latter fraction was not different from that of the pure drug. With ibuprofen it was demonstrated that complexation of drugs administered in high doses decreased the absorption. The suppository with the complex contained 1000 mg of solid substance. This large amount of solid particles behaved like a matrix preventing the spreading of the suppository and dissolution of the complex. The bioavailability of prednisolone from fatty suppositories was not increased by complexation with β-cyclodextrin, but the large variability in the absorption was reduced.
Polarization-independent C-band tunable filter based on cascaded Si-wire asymmetric Mach-Zehnder interferometer (2016)

We fabricated and characterized a polarization-independent tunable band-pass filter, composed of a four-stage Si-wire asymmetric Mach-Zehnder interferometer. The filter exhibited full tunability in the C-band, 2.2 nm bandwidth, and 2 dB on-chip loss.
THE PERMEABILITY OF ARTICULAR CARTILAGE (1968)

1. We have shown that the permeability of cartilage is the same in necropsy specimens as in the living animal. We have concluded that studies of material transport into cartilage carried out on necropsy specimens validly reflect in vivo conditions. 2. We have studied the effect of agitation of the fluid in which cartilage is immersed upon the rate of diffusion of substances into cartilage and have found that agitation increases the rate of penetration up to three or four fold. We believe that it may be inferred from this fact that the nutrition of cartilage is partly dependent on joint movement. 3. We have examined the permeability of the bone-cartilage interface to water and solutes and have found that in the adult no detectable material transfer occurs across this zone. In the child on the other hand the bone-cartilage interface appears to be permeable to water and solutes. 4. We have measured the diffusion coefficient of glucose in cartilage and have hence estimated the depth of cartilage which can be adequately supplied with glucose from the synovial fluid in the presence and absence of agitation. 5. We have examined both experimentally and theoretically the possible effect of intermittent loading on the rate of penetration of substances into cartilage. We have concluded that at low pressures intermittent loading contributes little to the material transfer into cartilage. At high pressures intermittent loading does lead to the transport of solutes into cartilage but it cannot significantly increase the rate of transfer above that attributable to normal diffusion. Loading cartilage surfaces for prolonged periods of time without allowing intermittent relaxation would be expected to lead to decreased diffusion, without any absorption of fresh fluid attributable to the action of a pump, and would thus result in an overall decrease in the rate of penetration of substances into cartilage.
Generation, alkyne cycloaddition, arene carbon-hydrogen activation, nitrogen-hydrogen activation and dative ligand trapping reactions of the first monomeric imidozirconocene (Cp2Zr:NR) complexes (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGeneration, alkyne cycloaddition, arene carbon-hydrogen activation, nitrogen-hydrogen activation and dative ligand trapping reactions of the first monomeric imidozirconocene (Cp2Zr:NR) complexesPatrick J. Walsh, Frederick J. Hollander, and Robert G. BergmanCite this: J. Am. Chem. Soc. 1988, 110, 26, 8729–8731Publication Date (Print):December 1, 1988Publication History Published online1 May 2002Published inissue 1 December 1988https://pubs.acs.org/doi/10.1021/ja00234a043https://doi.org/10.1021/ja00234a043research-articleACS PublicationsRequest reuse permissionsArticle Views2140Altmetric-Citations355LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Automatic generation of link collections and their visualization (2005)

In this paper, we describe a method of generating link collections in a user-specified category by comprehensively collecting existing link collections and analyzing their hyperlink references. Moreover, we propose a visualization method for a bird's-eye view of the generated link collections. Our methods are effective in grasping intuitively the trend of significant sites and keywords in a category.
Manifestaciones cutáneas en donantes de sangre portadores de HTLV-1 en comparación con donantes de sangre no portadores de HTLV-1 (2014)

Background: Most human T cell lymphotropic virus type 1 (HTLV-1) infected individuals are asymptomatic, but they commonly present cutaneous lesions that could be considered warning signs of the disease. Aim: To identify the main cutaneous manifestations present in HTLV-1 infected blood donors and compare them with healthy donors. Materials and Methods: Two blood donor groups from the blood bank of an emergency hospital were matched according to gender and age. One group was formed by HTLV-1 (+) (cases) and the other by HTLV-1 (-) donors (controls). A blind examiner to the serologic condition, evaluated their cutaneous manifestations. Results: Twenty five cases and 25 controls aged 18 to 60 years (24 females) were evaluated. One or more cutaneous manifestations were found in 24 (96%) cases and in 15 (60%) controls (p < 0.01). Inflammatory cutaneous diseases were found in 19 (76%) cases and in 9 (36%) controls (p < 0.01). Dermatophytosis was found in 18 (72%) cases and in 12 (48%) controls (NS). Conclusions: HTLV-1 infected Chilean subjects have a higher frequency of dermatoses than their healthy counterparts.
Creep Response of Sandwich Beams with a Metallic Foam Core (2002)

The creep response of metallic foam sandwich beams in 3-point bend is investigated numerically for the case of a metallic foam core and two steel faces. The face sheets are treated as elastic, while the foam core is modeled by a viscoplastic extension of the Deshpande-Fleck yield surface. This power-law creeping constitutive law has been implemented within the commercial finite element code ABAQUS. It is found that the beams creep by a variety of competing mechanisms, depending upon the choice of material properties and the geometric parameters. A failure map is constructed and effect of rate dependence on the load-deflection curves is quantified, and compared against the available experimental data.
High resolution 3C fiber laser micro-seismic geophone array for cross-well seismic (2017)

A two level 3-component distributed feed-back (DFB) fiber laser micro-seismic geophone array based on wavelength/space division multiplexing is developed. High resolution dynamic wavelength demodulation was realized with a coherent detection technology. The geophone array was tested in laboratory and showed that the detection capability of the weak vibration signals between 5-500 Hz was better than conventional moving-coil geophone. A cross-well test of the array was performed in a 100 m depth well in Changqing Oil Field in northwest China. The two level 3-component fiber laser micro-seismic geophone array was compared with the traditional in-well seismic geophone and showed better signal noise ratio (SNR) in the cross-well seismic signal acquisition. This 3C fiber laser micro-seismic geophone array system is promising in the cross-well seismic monitoring.
Atomic spectroscopy at NIST - 1995 (1996)

The current program at NIST to observe spectral lines of atoms and atomic ions and determine atomic energy levels is reviewed. Results for the doubly ionized atoms Zr III, Hg III and Dy III, which are astrophysically important, are summarized in some detail, as are recent results for the Li-like atoms Li I and Fe XXIV. Progress on installation of a very high resolution Fourier transform spectrometer at NIST is reported.
Culture, Human Resources and Organisations in Asia: Seeking a Model with 'Chinese Characteristics' (1998)

This article looks at culture, human resources and organisations. It argues that the transfer of HRM know-how should pay attention to local cultural contexts. The critique is underpinned by illustrations from East Asian (mainly Chinese) management practices.
Bistructures, Bidomains and Linear Logic (1997)

Bistructures are a generalisation of event structures which allow&lt;br /&gt;a representation of spaces of functions at higher types in an orderextensional setting. The partial order of causal dependency is replaced by two orders, one associated with input and the other with output in the behaviour of functions. Bistructures form a categorical model of Girard's classical linear logic in which the involution of linear logic is modelled, roughly speaking, by a reversal of the roles of input and output. The comonad of the model has an associated co-Kleisli category which is closely related to that of Berry's bidomains (both have equivalent non-trivial full sub-cartesian closed categories).
Combinational verification based on high-level functional specifications (1998)

We present a new combinational verification technique where the functional specification of a circuit under verification is utilized to simplify the verification task. The main idea is to assign to each primary input a general function, called a coordinate function, instead of a single variable function as in most BDD-based techniques. BDDs of intermediate nodes are then constructed based on these coordinate functions in a topological order from primary inputs to primary outputs. Coordinate functions depend on primary input variables and extra variables. Therefore combinational verification is performed not over the set of primary input variables but over the extended set of variables. Coordinate functions are chosen in such a way that in the process of computing intermediate functions the dependency on the primary input variables is gradually replaced with that on the extra variables, thereby making boolean functions associated with primary outputs simple functions only in terms of the extra variables. We show that such a smart choice of coordinate functions is possible with the help of the high-level functional specification of the circuit.
Novel HLA‐B*50:66 allele, identified by next‐generation sequencing in a Saudi individual (2020)

HLA-B*50:66 differs from HLA-B*50:01:01:01 by a single nucleotide substitution (C>A) in codon 153.
Primary Lifelong Delayed Ejaculation: Characteristics and Response to Bupropion (2010)

Lifelong DE is mainly associated with higher and idiosyncratic masturbatory activity, lower night emissions, infertility, longer IELT, lower orgasmic, and intercourse satisfaction domains of IIEF, higher anxiety and depression scores. Bupropion-SR in a daily dosage of 150 mg seemed to be of limited benefit in lifelong DE.
Staphylococcus aureus -Induced Corneal Inflammation Is Dependent on Toll-Like Receptor 2 and Myeloid Differentiation Factor 88 (2006)

Toll-like receptors (TLRs) expressed by the corneal epithelium represent a first line of host defense to microbial keratitis. The current study examined the role of TLR2, TLR4, and TLR9 and the common adaptor molecule myeloid differentiation factor 88 (MyD88) in a Staphylococcus aureus model of corneal inflammation. The corneal epithelia of C57BL/6, TLR2(-/-), TLR4(-/-), TLR9(-/-), and MyD88(-/-) mice were abraded using a trephine and epithelial brush and were exposed to heat- or UV-inactivated S. aureus clinical strain 8325-4 and other clinical isolates. Corneal thickness and haze were measured by in vivo confocal microscopy, neutrophil recruitment to the corneal stroma was quantified by immunohistochemistry, and cytokine production was measured by enzyme-linked immunosorbent assay. The exposure of corneal epithelium to S. aureus induced neutrophil recruitment to the corneal stroma and increased corneal thickness and haze in control C57BL/6 mice but not in TLR2(-/-) or MyD88(-/-) mice. The responses of TLR4(-/-) and TLR9(-/-) mice were similar to those of C57BL/6 mice. S. aureus-induced cytokine production by corneal epithelial cells and neutrophils was also significantly reduced in TLR2(-/-) mice compared with that in C57BL/6 mice. These findings indicate that S. aureus-induced corneal inflammation is mediated by TLR2 and MyD88 in resident epithelial cells and infiltrating neutrophils.
PHOAKS (1997)

article Free Access Share on PHOAKS: a system for sharing recommendations Authors: Loren Terveen Human-Computer Interface Research, AT&T Labs--Research, Florham Park, NJ Human-Computer Interface Research, AT&T Labs--Research, Florham Park, NJView Profile , Will Hill Human-Computer Interface Research, AT&T Labs--Research, Florham Park, NJ Human-Computer Interface Research, AT&T Labs--Research, Florham Park, NJView Profile , Brian Amento Computer Science Department, Virginia Tech. Computer Science Department, Virginia Tech.View Profile , David McDonald Information and Computer Science Department, University of California, Irvine Information and Computer Science Department, University of California, IrvineView Profile , Josh Creter Pomona College, Claremont, Calif. Pomona College, Claremont, Calif.View Profile Authors Info & Claims Communications of the ACMVolume 40Issue 3March 1997 pp 59–62https://doi.org/10.1145/245108.245122Published:01 March 1997Publication History 350citation2,341DownloadsMetricsTotal Citations350Total Downloads2,341Last 12 Months178Last 6 weeks40 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Abstract 15020: Transcriptomic and Epigenomic Resemblance of Terminally Differentiated Cells Derived From Isogenic Human iPSCs and Nuclear Transfer Derived ESCs (2016)

Human pluripotent stem cells (PSCs) hold great promise for disease modeling, drug discovery, and regenerative medicine. Currently, patient-specific PSCs can be created via two approaches: somatic cell nuclear transfer (SCNT) by enucleated oocytes and iPSC reprogramming by ectopic expression of four transcription factors. Recent studies suggest that human SCNT-derived embryonic stem cells (nt-ESCs) are more similar to in vitro fertilized embryo derived ESCs (IVF-ESCs) than iPSCs at both transcriptomic and epigenomic levels. As terminally differentiated cells (i.e., cardiomyocytes, hepatocytes, neurons, and endothelial cells) are mostly desired for clinical application of human PSCs, here we assessed the molecular and functional similarity of terminally differentiated cells derived from human isogenic iPSCs and nt-ESCs. We differentiated three types of PSCs (iPSCs, nt-ESCs, and IVF-ESCs) into beating cardiomyocytes (PSC-CMs) and functional endothelial cells (PSC-ECs), respectively. During the process of induced differentiation, human nt-ESCs displayed closer dynamic marker gene expression profiles to IVF-ESCs than iPSCs. However, terminally differentiated cells (CMs and ECs) derived from iPSCs and nt-ESCs showed comparable differentiation efficiency, lineage marker gene expression, heterogeneity, nitric oxide release and tube formation capacity. Furthermore, iPSC-CMs were clustered more closely to nt-ESC-CMs than IVF-ESC-CMs at transcriptional level revealed by RNA-seq. DNA methylome analysis by RRBS-seq indicated that iPSC-CMs and iPSC-ECs were epigenetically similar to nt-ESC-CMs and nt-ESC-ECs, respectively, but were distinguishable from IVF-ESC derivatives. Thus, for generating terminally differentiated cells, human iPSCs are comparable to their isogenic nt-ESCs with respect to transcriptomic, epigenomic, and functional features.
Structure of Adeno-Associated Virus Serotype 8, a Gene Therapy Vector (2007)

Adeno-associated viruses (AAVs) are being developed as gene therapy vectors, and their efficacy could be improved by a detailed understanding of their viral capsid structures. AAV serotype 8 (AAV8) shows a significantly greater liver transduction efficiency than those of other serotypes, which has resulted in efforts to develop this virus as a gene therapy vector for hemophilia A and familial hypercholesterolemia. Pseudotyping studies show that the differential tissue tropism and transduction efficiencies exhibited by the AAVs result from differences in their capsid viral protein (VP) amino acids. Towards identifying the structural features underpinning these disparities, we report the crystal structure of the AAV8 viral capsid determined to 2.6-A resolution. The overall topology of its common overlapping VP is similar to that previously reported for the crystal structures of AAV2 and AAV4, with an eight-stranded beta-barrel and long loops between the beta-strands. The most significant structural differences between AAV8 and AAV2 (the best-characterized serotype) are located on the capsid surface at protrusions surrounding the two-, three-, and fivefold axes at residues reported to control transduction efficiency and antibody recognition for AAV2. In addition, a comparison of the AAV8 and AAV2 capsid surface amino acids showed a reduced distribution of basic charge for AAV8 at the mapped AAV2 heparin sulfate receptor binding region, consistent with an observed non-heparin-binding phenotype for AAV8. Thus, this AAV8 structure provides an additional platform for mutagenesis efforts to characterize AAV capsid regions responsible for differential cellular tropism, transduction, and antigenicity for these promising gene therapy vectors.
Magnetic recording channel model with intertrack interference (1991)

The authors propose a multichannel model for saturation recording which includes interference from adjacent tracks. In saturation recording, the signal is recorded as a series of flux reversals on the medium. Each track is a pulse amplitude modulated (PAM) signal, where the pulse shape is the system response to a flux reversal. The old information (OI) in each guard band is also modeled as a single PAM signal. The side reading properties of the head are modeled using the reciprocity integral to compute flux transition response. Using a result of D.A. Lindholm (1977) to represent the field of an inductive head, the authors compute specific channel models for various values of misregistration. They determine the pulse shape as a function of the head-to-track registration for each adjacent track and OI track.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
In Response to Letter to the Editor Regarding “Mortality Associated With Tracheostomy Complications in the United States: 2007–2016” (2019)

Peer Reviewed
Supplementary Figure 6 from HDM2 Regulation by AURKA Promotes Cell Survival in Gastric Cancer (2023)

&lt;p&gt;PDF file 179K, Frequent overexpression and direct correlation between AURKA and HDM2 in human esophageal adenocarcinoma tissues&lt;/p&gt;
Effect of oral glucocorticoid treatment on serum inflammatory markers in acute asthma (2000)

These data suggest that T cell mediated inflammation may persist in childhood asthma despite apparent clinical remission associated with conventional doses of prednisolone. The long term consequences of persistent inflammation after an apparently treated acute attack of asthma require clarification. Clinical assessment and pulmonary function are inadequate surrogates for airway inflammation.
Tele-virtual Reality Of Dynamic Mechanical Model (2005)

In this paper we propose a technique for tele-virtual reality of dynamic mechanical models, which means that one dynamic mechanical model can be shared by peoples in distant places. Since a stabil- ity issue due to time delays arises in the system, we employed a scattering technique developed for a tele- operator system and a kind of passive adaptive con- trollers. Furthermore, restrictions due to a simple digi- tal implementation of the scattering transformation are discussed and some conditions for stability are shown. The proposed method is applied to a remote tug of war system and the effectiveness is verified.
Triple-FRET multi-purpose fluorescent probe for three-protease detection (2022)

A new, robust and reliable methodology for three-protease screening in a single-enzyme mode has been developed and verified, employing a multi-purpose peptide probe with three selectively cleavable sites furnished with four fluorophores. A triple-FRET-based single-excitation quadruple-emission concept for unambiguous sensing of trypsin, chymotrypsin and caspase-8 in the lowest detectable concentrations of 0.5 ng mL<sup>-1</sup>, 0.2 μg mL<sup>-1</sup>, and 2 U mL<sup>-1</sup>, respectively, has been applied and graphically depicted. Then the developed 4-dye probe has been also studied from the perspective of simultaneous two-protease screening, which was found only partially feasible, primarily due to unselective chymotrypsin cleavage.