gebhart/patrepeval huggingface dataset:
Role of the TATA box in transcription of the mouse mammary tumor virus long terminal repeat. (1995)

An in vitro transcription system from mammary cells was established to study transcription of the long terminal repeat (LTR) of the mouse mammary tumor virus (MMTV). Experiments with progressive 5'-deletion constructs of the MMTV LTR revealed that a 19-base pair (bp) region from -41 to -23 bp, encompassing the TATA box and flanking DNA sequence, was as transcriptionally active as larger promoter constructs, both in nuclear extracts from human mammary cell lines (T47D and MCF7) and a nonmammary cell line (HeLa). The cell-free system was capable of supporting transcriptional induction by factors binding upstream of the TATA box, however, since purified glucocorticoid receptor-induced transcription in larger promoter constructs encompassing the MMTV hormone-responsive elements. Transcription from two other promoters, the adenovirus major late promoter and the human immunodeficiency virus LTR, also revealed a significant transcriptional contribution of upstream elements. The 19-bp TATA region from the MMTV LTR was shown to have considerably more activity in this transcription system than comparable TATA regions from other promoters. Sequences critical to the MMTV TATA region were evaluated by single base pair mutagenesis and found to comprise a consensus TATA box sequence, TATAAAA, as well as a single A just upstream of the TATAAAA sequence. Thus, the high level of basal transcription observed with the TATA region from MMTV is due to a perfect consensus TATA box sequence and a single base immediately 5' adjacent. It is likely that the high basal rate of transcription observed with this TATA box region on histone-free templates represents an inappropriate level of basal expression and that a complete evaluation of transactivation mechanisms in this system will require the recapitulation in vitro of the chromatin-mediated repressive state that exists in vivo.
Autism genetic database (AGD): a comprehensive database including autism susceptibility gene-CNVs integrated with known noncoding RNAs and fragile sites (2009)

AGD comprises a comprehensive list of susceptibility genes and copy number variations reported to-date in association with autism, as well as all known human noncoding RNA genes and fragile sites. Such a unique and inclusive autism genetic database will facilitate the evaluation of autism susceptibility factors in relation to known human noncoding RNAs and fragile sites, impacting on human diseases. As a result, this new autism database offers a valuable tool for the research community to evaluate genetic findings for this complex multifactorial disorder in an integrated format. AGD provides a genome browser and a web based query client for conveniently selecting features of interest. Access to AGD is freely available at http://wren.bcf.ku.edu/.
Identification of Human Strains of Actinomyces viscosus (1969)

Catalase-positive actinomycetes which closely resemble the "hamster organism" described by Howell have been isolated from dental calculus and other human sources. These cultures could not be distinguished from the hamster strains on the basis of morphology, oxygen requirements, biochemical reactions, or cell wall composition. These human isolates have been classified with the hamster strains as Actinomyces viscosus. The strains from hamster and human sources fell into two serotypes. Serotype 1 contains the hamster strains plus one strain of unknown origin, whereas serotype 2 contains all of the human strains.
I.R.C. 6103: Let's Get to the Source of the Problem (1999)

Id. 6103(b)(1).Return information is defined as (A) a taxpayer's identity, the nature, source
Sustainable Mortars with Incorporation of Microencapsulated Phase Change Materials (2015)

The construction industry is responsible for high energy and raw materials consumption. Thus, it is important to minimize the high energy consumption by taking advantage of renewable energy sources and reusing industrial waste, decreasing the extraction of natural materials. The mortars with incorporation of phase change materials (PCM) have the ability to regulate the temperature inside buildings, contributing to the thermal comfort and reduction of the use of heating and cooling equipment, using only the energy supplied by the sun. The simultaneous incorporation of PCM and fly ash (FA) can reduce the energetic consumption and the amount of materials landfilled. However, the addition of these materials in mortars modifies its characteristics. The main purpose of this study was the production and characterization in the fresh and hardened state of mortars with incorporation of different contents of PCM and FA. The binders studied were aerial lime, hydraulic lime, gypsum and cement. The proportion of PCM studied was 0%, 20%, 40% and 60% of the mass of the sand. The content of fly ash added to the mortars was 0%, 20%, 40% and 60% of the mass of the binder. It was possible to observe that the incorporation of PCM and fly ash in mortars caused differences in properties such as workability, microstructure, water absorption, compressive strength, flexural strength and adhesion.
When blood transfusion medicine becomes complicated due to interference by monoclonal antibody therapy (2015)

CD38 MoAb therapy causes false-positive results in the IAT. The reliability of the test could be restored by adding a neutralizing agent against the CD38 MoAb to the patient's plasma. This study emphasizes that during drug development, targeted therapeutics should be investigated for potential interference with laboratory tests. Clinical laboratories should be informed when patients receive MoAb treatments and matched laboratory tests to prevent interference should be employed.
VISUALISATION OF FLOW PATTERNS IN FLAT PLATE PULSATING HEAT PIPE: INFLUENCE OF HYDRAULIC BEHAVIOUR ON THERMAL PERFORMANCES (2014)

In this experimental study, a specific flat plate pulsating heat pipe (FPPHP) with ethanol as working fluid has been tested. The experimental test bench consists of a copper block at the surface of which a single 10 turns groove has been machined. A transparent glass pressed in front of the top surface and two high speed cameras allow the fluid flow patterns to be visualized during the operations. Thus, the analysis of the synchronized recorded images permits to link the hydraulic behavior of the fluid inside the PHP to its thermal response as regards operating conditions (heat power applied, cooling temperature, inclination). A quantitative and qualitative analysis of the results show that in vertical position the flow pattern are almost always annular whatever the heat power applied, with liquid storage in some adjacent channels; in horizontal position, the evaporator is progressively dried out with some oscillations for specific heat powers. Lastly by putting the PHP in an original orientation with the gravity, named edge orientation, the fluid motion is transmitted from one branch to another sequence, induced by the pressure difference increased by the gravity forces between channels.
Machine-Based Decoding of Paralinguistic Vocal Features (2018)

Machines are able to obtain rich information from the human voice with a certain reliability. This can comprise information about the affective or mental state, but also traits of the speaker. This chapter introduces all the different technical steps needed in such intelligent voice analysis. Typically, the first step involves extraction of meaningful acoustic features, which are then transformed into a suitable representation. The acoustic information can be augmented by linguistic features originating from a speech-to-text transcription. The features are finally decoded on different levels using machine-learning methods. Recently, ‘deep learning’ has received growing interest, where deep artificial neural networks are used to decode the information. From this, end-to-end learning has evolved, where even the feature extraction step is learned seamlessly, through to the decoding step, mimicking the recognition process in the human brain. Subsequent to the description of according and further frequently encountered methods, the chapter concludes with some future perspective.
Stage-specific meniscal features predict progression of osteoarthritis of the knee: a retrospective cohort study using data from the osteoarthritis initiative (2019)

Our findings suggested (1) a larger meniscal LD at the baseline predicted progression of knee OA after 24 months and (2) a larger meniscal width and smaller meniscal angle predicted progression of knee OA after 24 months.
Drought‐ and desiccation‐induced modulation of gene expression in plants (2002)

Desiccation is the extreme form of dehydration. Tolerance of desiccation is acquired by seeds and in resurrection plants, a small group of angiosperms. Desiccation tolerance is the result of a complex cascade of molecular events, which can be divided into signal perception, signal transduction, gene activation and biochemical alterations leading to acquisition of tolerance. Many of these molecular processes are also observed during the dehydration of non-tolerant plants. Here we try to give an overview of the gene expression programmes that are triggered by dehydration, with particular reference to protective molecules and the regulation of their expression. Potential transgenic approaches to manipulating stress tolerance are discussed.
Study of charge transport mechanisms in125I-induced DNA damage at various temperatures (2012)

We thus conclude that charge transport by the hopping mechanism is not a major factor in (125)I-decay-induced DNA damage at biologically relevant temperatures.
Ultrafine Hydrogel Nanoparticles: Synthetic Approach and Therapeutic Application in Living Cells (2007)

Licensed to kill: A method for obtaining ultrafine hydrophilic polyacrylamide-based nanoparticles that encapsulate meta-tetra(hydroxyphenyl)chlorin (mTHPC) has been developed. Rat C6 glioma cells exposed to infrared light were killed (red) in the presence of the mTHPC-encapsulating nanoparticles while the cells without exposure to light were still alive (green). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z603927_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Letter by Consolo and Pappalardo Regarding Article, “Comprehensive Analysis of Stroke in the Long-Term Cohort of the MOMENTUM 3 Study: A Randomized Controlled Trial of the Heartmate 3 Versus the Heartmate II Cardiac Pump” (2019)

The article by Colombo et al 1 revealed an extremely low rate of stroke events in patients supported with the HeartMate 3. This study follows previous reports that showed that the HeartMate 3 has abated the incidence of pump thrombosis 2 and confirms the low thrombogenic potential of this pump. The analysis included patients managed with oral anticoagulation alone (warfarin or heparin, with a targeted international normalized ratio of 2.0-3.0), antiplatelet therapy alone (aspirin 81-325 mg daily), or both. We believe that this study has important implications that need to be discussed which might contribute to further reducing HeartMate 3 hemocompatibility-related adverse events.
Oligomeric flavanoids. Part 10. Structure and synthesis of the first tetrahydropyrano[3,2-g]chromenes related to (4,6)-bis-(–)-fisetinidol profisetinidins (1990)

The range of natural bis-fisetinidol profisetinidins is extended by identification of (+)-epifisetinidol-(4α,6)-(–)-fisetinidol (5), (4α,6)-bis-(+)-epifisetinidol (7), (4β,6′)-bis-(–)-fisetinidol (13), and (–)-fisetinidol-(4β,6′)-(+)-epifisetinidol (15). They are accompanied in the heartwood of Colophospermum mopane by the first tetrahydropyrano[3,2-g]chromenes (17), (19), (21), and (23), related to the (4,6)-bis-(–)-fisetinidol profisetinidins (1) and (2). Under mild basic conditions the latter compounds undergo pyran rearrangements affording tetrahydropyrano[3,2-g]chromenes (17), (19), (21), and (23) as well as two additional C-2(F) epimeric pairs (25), (27), and (29), (31). The same intermediate quinone-methide presumably leading to the C-ring-isomerized analogues may feasibly also explain the genesis of the variety of compounds in the mopane displaying a C-2 epimeric relationship to the predominant (–)-fisetinidol monomeric precursor.
Titelei/Inhaltsverzeichnis (2018)

Das Konzept der Soldatenmatrix beschreibt psychosoziale Konstellationen, die in Gesellschaften stattfinden, die von Krieg und Gewalt geprägt sind. Existenzielle Ängste, hierarchische Strukturen von Befehl und Gehorsam und Bedürfnisse nach Ruhm und Ehre führen zu einer Überidentifikation mit Positionen der Macht. Aggressionshemmende Gefühle wie Scham, Schuld und Empathie verlieren an Bedeutung. Hiervon sind nicht nur ehemalige Soldaten betroffen, sondern ein »soldatenhaftens Selbst« nimmt Einfluss auf alle Rollen und Beziehungen in der Gesellschaft.
Ion implanted, radical-rich surfaces for the rapid covalent immobilization of active biomolecules (2013)

Protein immobilization through the use of direct radical induced covalent coupling is described. Ions implanted in a polymer surface generate a highly cross-linked surface layer that is rich in radicals. These radicals can diffuse to the surface and covalently immobilize physically adsorbed proteins, as illustrated in a kinetic model for the covalent attachment process. Radical induced covalent coupling provides rapid covalent attachment, while also retaining native protein conformation and enabling control over the composition of the adsorbed protein layer when adsorbed from a protein mixture. Advantages of using this method for improving the biocompatibility of implanted biomedical devices and for immobilizing antibodies in protein microarrays for disease diagnosis and early detection are highlighted.
Capacitance enhancement techniques for sub-100 nm trench DRAMs (2002)

Essential techniques that allow further scaling of trench DRAMs beyond 100 nm have been developed. Al/sub 2/O/sub 3/ was implemented as a high-k node dielectric in silicon-insulator-silicon trench capacitors. Al/sub 2/O/sub 3/ films were deposited by ALD with excellent step coverage at aspect ratios of up to AR/spl ap/60. Even after thermal stressing at 1050/spl deg/C an effective oxide thickness (=capacitance equivalent thickness) of t/sub ox/=3.6 nm and a leakage current of well below 1 fA/cell were obtained. Both selective and non-selective HSG Si was formed inside high-aspect ratio straight and bottled trenches. On fully integrated 0.17 /spl mu/m trench DRAMs, a storage capacitance of 45 fF/cell with acceptable leakage current was achieved. Both the aluminum oxide node dielectric and the HSG silicon have thus been proven to withstand the high thermal budget required for integration into trench DRAMs. In addition, a silicon etch process was developed that allows trench aspect ratios of AR/spl ap/60 at critical dimensions of CD=80 nm.
Development of Terramechanics-Based Slope Traveling Model for Crawler Vehicles and Model-Based Design of Slope Traveling Controller (2019)

Crawler vehicles are often used in dangerous sites such as forestry land and sediment disaster sites because of their high traveling performance on bad roads. In various situations where crawler vehicles are used, slope traveling is considered one of the most dangerous situations. In a steep slope, the vehicle must follow precisely the safe target trajectory so as not to slip down. Thus, the operator needs to skillfully adjust the rotational speed of the crawler according to the changing situation around the vehicle. Consequently, the automatic driving technology that automates traveling a steep slope is necessary for the operator's safety. For a case study in a controller design, a traveling simulation model with low calculation cost is necessary. In this study, the slope traveling simulation model based on the theory of Terramechanics was constructed. As a result, the model has overwhelmingly low calculation cost than a model using DEM. In addition, in order to verify the usefulness of this model in traveling controller design, a case study of a target path following simulation with PID controller was carried out. As the results, it’s indicated that our proposed model can be applied for a travel controller development.
Temperature stabilisation of light-emitting diode radiation (1988)

Some problems of temperature stabilisation of light-emitting diode (LED) radiation have been discussed in the paper. Designs of electronic circuits for automatic compensation of the temperature variations in LED radiation flux have been presented.
Damage-Sensitive and Domain-Invariant Feature Extraction for Vehicle-Vibration-Based Bridge Health Monitoring (2020)

We introduce a physics-guided signal processing approach to extract a damage-sensitive and domain-invariant (DS & DI) feature from acceleration response data of a vehicle traveling over a bridge to assess bridge health. Motivated by indirect sensing methods' benefits, such as low-cost and low-maintenance, vehicle-vibration-based bridge health monitoring has been studied to efficiently monitor bridges in real-time. Yet applying this approach is challenging because 1) physics-based features extracted manually are generally not damage-sensitive, and 2) features from machine learning techniques are often not applicable to different bridges. Thus, we formulate a vehicle bridge interaction system model and find a physics-guided DS & DI feature, which can be extracted using the synchrosqueezed wavelet transform representing non-stationary signals as intrinsic-mode-type components. We validate the effectiveness of the proposed feature with simulated experiments. Compared to conventional time-and frequency-domain features, our feature provides the best damage quantification and localization results across different bridges in five of six experiments.
Incidence and prevalence of coma in the UK and the USA (2022)

The epidemiology of coma is unknown because case ascertainment with traditional methods is difficult. Here, we used crowdsourcing methodology to estimate the incidence and prevalence of coma in the UK and the USA. We recruited UK and US laypeople (aged ≥18 years) who were nationally representative (i.e. matched for age, gender and ethnicity according to census data) of the UK and the USA, respectively, utilizing a crowdsourcing platform. We provided a description of coma and asked survey participants if they-'right now' or 'within the last year'-had a family member in coma. These participants (UK <i>n</i> = 994, USA <i>n</i> = 977) provided data on 30 387 family members (UK <i>n</i> = 14 124, USA <i>n</i> = 16 263). We found more coma cases in the USA (<i>n</i> = 47) than in the UK (<i>n</i> = 20; <i>P</i> = 0.009). We identified one coma case in the UK (0.007%, 95% confidence interval 0.00-0.04%) on the day of the survey and 19 new coma cases (0.13%, 95% confidence interval 0.08-0.21%) within the preceding year, resulting in an annual incidence of 135/100 000 (95% confidence interval 81-210) and a point prevalence of 7 cases per 100 000 population (95% confidence interval 0.18-39.44) in the UK. We identified five cases in the USA (0.031%, 95% confidence interval 0.01-0.07%) on the day of the survey and 42 new cases (0.26%, 95% confidence interval 0.19-0.35%) within the preceding year, resulting in an annual incidence of 258/100 000 (95% confidence interval 186-349) and a point prevalence of 31 cases per 100 000 population (95% confidence interval 9.98-71.73) in the USA. The five most common causes were stroke, medically induced coma, COVID-19, traumatic brain injury and cardiac arrest. To summarize, for the first time, we report incidence and prevalence estimates for coma across diagnosis types and settings in the UK and the USA using crowdsourcing methods. Coma may be more prevalent in the USA than in the UK, which requires further investigation. These data are urgently needed to expand the public health perspective on coma and disorders of consciousness.
Surface Changes in Thermally Sprayed Hard Coatings by Wear of Different Abrasives (2004)

Abstract Thermally sprayed hard coatings, including tungsten carbide and chromium carbide cermets and other hard metallic materials, were studied in two types of wear tests. Surfaces of the coatings were worn by coarse and hard quartz sand in a rubber-wheel dry abrasion wear test, and by fine and soft kaolin abrasive in a wet slurry abrasion wear test. The aim of the work was to study how the surfaces retain their high polished finish and gloss, and the type of wearing of different coatings and materials. The results showed that coatings with hard tungsten carbides were worn preferentially by removal of the the binder material. Cermet coatings with softer chromium carbides, and with another types of uniform microstructures showed more uniform wear and better retained their glossy finish.
Advanced Concentrating Thermal Technologies for Power and Process Heat Generation (2017)

Concentrating solar thermal technologies are in a phase of commercial implementation for about 10 years. Up to now parabolic trough systems using synthetic thermal oil as heat transfer medium and a molten salt heat storage system is the dominating technology in the market. In parallel smaller units to provide process heat in a decentralized markets are evolving. Solar tower technology using molten salt as heat transfer medium is currently emerging with the promise to reduce the cost for dispatchable power significantly. A variety of other new heat transfer fluids with different particular benefits have been developed in the past to enable further cost reductions. This range from new silicon based thermal, oil, direct steam generation, atmospheric air, advanced salt mixtures, liquid metals and ceramic particles. The talk will introduce the different concepts and evaluate the maturity and potential for both centralized power production and decentralized process heat supply.
FACTS: fault coverage estimation by test vector sampling (2002)

We propose a new statistical technique for estimating fault coverage in combinational circuits. Our method requires fault-free simulation of a random sample of vectors from the test vector set. Fault coverage is computed from controlabilities and observabilities both defined as probabilities and the method is applicable to any fault model like stuck-at-faults or delay faults. Experimental results are presented for path and transition delay faults.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Ru(iii)-catalyzed C4–H bond cyanoalkoxylation of 1-naphthylamine derivatives with azobisisobutyronitrile (2022)

A simple and efficient protocol for ruthenium-catalyzed C4–H bond cyanoalkoxylation of 1-naphthylamine derivatives with AIBN was developed under an oxygen atmosphere in moderate to good yields.
Hypersonic Lifting Body Windward Surface Flow-Field Analysis for High Angles of Incidence (1973)

Abstract : Formulation and application of a windward surface flow-field (inviscid and viscous) analysis is presented for general lifting body configurations at high angles of incidence under hypersonic perfect gas conditions. The technique applies a strip theory concept, leading to an infinite extent yawed body treatment applied in the windward surface crossflow plane for both the inviscid and viscous (boundary layer) flow fields. The boundary-layer analysis is based on the governing equations for yawed blunt body boundary layers.
HTTP Extensions for Distributed Authoring -- WEBDAV (1999)

specifies a set of methods, headers, and content-types ancillary to HTTP/1.1