gebhart/patrepeval huggingface dataset:
Analysis of electrical, dielectric, and electromagnetic interference shielding behavior of graphite filled high density polyethylene composites (2008)

Abstract Conducting polymer composites were prepared by hot compression molding of high‐density polyethylene (HDPE) prelocalized with graphite (Gr). The variation of room temperature electrical conductivity, dielectric constant, and Shore‐D hardness as a function of graphite content were studied below and above percolation threshold. The percolation threshold at which insulator‐conductor transition takes place is estimated to be 0.029 volume fraction of graphite. The observed increase in dielectric constant with addition of graphite also found to be percolative in nature. Above percolation threshold, the dielectric constant is found to decrease sharply with increase in frequency. Electromagnetic shielding effectiveness of HDPE/Gr composites was evaluated in the X‐band frequency range. The composites were found to possess both positive and negative temperature coefficient of resistance. Reproducibility of electrical resistivity with temperature was observed only below the processing temperature. POLYM. ENG. SCI., 2008. © 2008 Society of Plastics Engineers
Comparative responsiveness of Parkinson's disease scales to change over time (2009)

The objective of the study is to examine the comparative responsiveness of outcome measures to assess progression over time in Parkinson's disease (PD). One hundred twenty-eight patients participating in a clinic-based naturalistic study of PD were assessed with the Hoehn and Yahr, UPDRS, MMSE, PDQ-39, PDQL, EQ-5D, and BDI scales at baseline and at 1 year. In addition, 82 patients in a community-based study of patients with PD who had completed self-rated Schwab and England, PDQ-39, EQ-5D, and BDI scales at baseline, were sent the same questionnaires at 1 and 4 years. Responsiveness was assessed using t-tests, standardised effect size, and standardised response mean. In both samples, the Hr-QoL measures were less responsive to change over time than the impairment and disability scales (Hoehn and Yahr, UPDRS, Schwab and England scales). In addition, in the clinic-based sample, Hoehn and Yahr and UPDRS ADL scale ("on") were more responsive to progression over time than UPDRS motor part and ADL part ("off"). Hr-QoL measures are less responsive to change over time than measures of impairment and disability. Although this suggests that these measures are less accurate in detecting subtle changes, it may also indicate that the multifactorial subjective assessment of Hr-QoL adapts to changes over time. Global assessment of overall impairment and disability (which incorporates motor and nonmotor features of PD), however, appeared relatively responsive to change over time in patients in a naturalistic setting.
Expansion of the Clavulanic Acid Gene Cluster: Identification and In Vivo Functional Analysis of Three New Genes Required for Biosynthesis of Clavulanic Acid by Streptomyces clavuligerus (2000)

Clavulanic acid is a potent inhibitor of beta-lactamase enzymes and is of demonstrated value in the treatment of infections by beta-lactam-resistant bacteria. Previously, it was thought that eight contiguous genes within the genome of the producing strain Streptomyces clavuligerus were sufficient for clavulanic acid biosynthesis, because they allowed production of the antibiotic in a heterologous host (K. A. Aidoo, A. S. Paradkar, D. C. Alexander, and S. E. Jensen, p. 219-236, In V. P. Gullo et al., ed., Development in industrial microbiology series, 1993). In contrast, we report the identification of three new genes, orf10 (cyp), orf11 (fd), and orf12, that are required for clavulanic acid biosynthesis as indicated by gene replacement and trans-complementation analysis in S. clavuligerus. These genes are contained within a 3.4-kb DNA fragment located directly downstream of orf9 (cad) in the clavulanic acid cluster. While the orf10 (cyp) and orf11 (fd) proteins show homologies to other known CYP-150 cytochrome P-450 and [3Fe-4S] ferredoxin enzymes and may be responsible for an oxidative reaction late in the pathway, the protein encoded by orf12 shows no significant similarity to any known protein. The results of this study extend the biosynthetic gene cluster for clavulanic acid and attest to the importance of analyzing biosynthetic genes in the context of their natural host. Potential functional roles for these proteins are proposed.
Stunned Myocardium Following Prolonged Cardiopulmonary Bypass: Effect of Warm versus Cold Cardioplegia in the Canine Model (1994)

"Stunned myocardium" is defined as the prolonged but transient postischemic contractile dysfunction of viable myocardium that has been salvaged by reperfusion. This phenomenon, although first characterized in the experimental canine model of coronary artery occlusion/reperfusion, also occurs following transient global ischemia. Moreover, despite the superb cardioprotection conferred by administration of cold cardioplegia during aortic cross-clamping, stunned myocardium is a well-recognized sequela of prolonged cardiopulmonary bypass. Using the anesthetized open chest dog, we tested the concept that continuous retrograde infusion of warm blood cardioplegia would effectively prevent ischemia during prolonged aortic cross-clamping and thereby preclude the development of stunned myocardium following bypass. Thirteen dogs were placed on cardiopulmonary bypass and randomized to receive: (1) continuous retrograde administration of warm blood cardioplegia (n = 8); or (2) intermittent retrograde cold blood cardioplegia (n = 5) during a 3-hour cross-clamp period. Left ventricular (LV) systolic function (i.e., area LV ejection fraction and posterior LV free wall thickening assessed by two-dimensional echocardiography) and hemodynamic parameters were monitored at baseline and at 1 and 2 hours postbypass and, at the end of the protocol, transmural myocardial biopsies were obtained for electron microscopic analysis. All dogs in both treatment groups showed electron microscopic evidence of mild and reversible morphological injury indicative of stunned myocardium, with no difference between dogs that received warm versus cold cardioplegia. Direct comparison of LV function between the two groups was confounded by a profound decrease in afterload in dogs that received cold cardioplegia. However, incorporation of systemic vascular resistance as a covariate revealed that LV function following bypass was modestly depressed at approximately 85% of baseline values, and that continuous administration of warm cardioplegia did not prevent this hypokinesis. Thus, in our canine model: (1) morphological injury and LV dysfunction induced by 3 hours of aortic cross-clamping is subtle; and (2) continuous retrograde infusion of warm blood cardioplegia during the cross-clamp period failed to preclude myocardial stunning following prolonged cardiopulmonary bypass.
The Ellipsometric Measurements of a Curved Surface (2005)

A three-intensity imaging ellipsometric technique is proposed to investigate the surface topography as well as the refractive index profile (RIP) of a lens. The azimuth deviation of polarizer caused by the tilting of a SiO 2 thin film on Si substrate was investigated after a careful calibration on the azimuth position of polarizer of the water-surface. The azimuth deviation of polarizer is proved to be the local surface normal; thus we can determine not only the radius of curvature of a Plano-Convex lens from the measurement, but also its incident-angle-corrected RIP.
Abstract 3444: LINC00152 regulates cell proliferation via p38 signaling and overexpression predicts poor patient survival in lung cancer (2017)

Abstract Lung cancer is a molecularly-heterogenous disease and the leading cause of cancer mortality. The molecular basis for this heterogeneity remains incompletely understood. In the past few years, long non-coding RNAs (lncRNAs) have emerged as novel mechanisms in mediating cancer biology, although most lncRNAs are still undiscovered. LINC00152 has been identified as highly associated with the tumorigenesis and development in gastric cancer, colon cancer and hepatocellular carcinoma, however, the expression level and its oncogenic roles in lung cancer remains unknown. In the present study, we employed next generation RNA sequencing analysis to reveal dysregulated lncRNAs in lung cancer utilizing datasets of 461 lung adenocarcinomas (LUAD) and 156 normal lung tissues from 3 separate institutions. We found that LINC00152 was 4-fold (p &amp;lt;0.001) overexpressed in lung tumors as compared to their adjacent normal tissues with AUC &amp;gt; 0.8 in these 3 data sets. Patients with high LINC00152 expression have significantly poorer survival than those with low expression (log-rank test, p = 0.003). We verified this diagnostic/prognostic potential in an independent cohort of lung tumor tissues by quantitative RT-PCR. Cell proliferation and colony formation ability were decreased after knockdown of LINC00152 using siRNAs in lung cancer cell lines. The expression of LINC00152 was found primarily in the cytoplasm by qRT-PCR analysis. Trichostatin A treatment indicated that histone acetylation could be one of the mechanisms underlying LINC00152 overexpression in NSCLC and cell-based analyses showed p38 signaling was mainly affected by LINC00152 in vitro. Taken together, our study suggests that LINC00152 is involved in lung tumor growth, may have potential as diagnostic/prognostic marker and that further characterization of this lncRNA as a novel therapeutic target for lung cancer is warranted. Note: This abstract was not presented at the meeting. Citation Format: Shumei Feng, Jie Zhang, Wenmei Su, Shengbin Bai, Lei Xiao, Zhuwen Wang, Jules Lin, Rishindra Reddy, Andrew Chang, David Beer, Guoan Chen. LINC00152 regulates cell proliferation via p38 signaling and overexpression predicts poor patient survival in lung cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 3444. doi:10.1158/1538-7445.AM2017-3444
Gastric non-Helicobacter pylori Helicobacter infections: origin and significance for human health (2011)

Besides the well-known gastric pathogen Helicobacter pylori, other helicobacters with typical spiral morphology have been detected in a minority of human patients presenting for upper gastrointestinal endoscopy.This group of non-H.pylori helicobacters (NHPH), also referred to as H. heilmannii sensu lato, includes gastric Helicobacter species colonizing the stomach of carnivores and H. suis, naturally colonizing the stomach of pigs.Previous epidemiological reports have suggested that direct contact with animals, especially pigs, is a risk factor for humans to contract an infection with one of these bacteria.Recently, we also demonstrated the presence of viable H. suis bacteria in pork samples, suggesting that pork can serve as a source of H. suis infections for humans.Disregarding the source of infection, NHPH can cause severe gastric pathology in rodent models of human gastric disease.In contrast to the predominant Th1/Th17 inflammatory response associated with a H. pylori infection, H. suis rather causes a Th2/Th17 response, which may lead to the development of MALT lymphomalike lesions, indeed observed in long-term infected Mongolian gerbils.Besides a pronounced inflammatory response, H. suis also causes necrosis of parietal cells in experimentally infected mice and gerbils, despite the absence of homologues of known H. pylori virulence factors such as the cagPAI and VacA.Recently, we have identified H. suis GGT as the key cell death-inducing factor.Through degradation of reduced glutathione into its degradation products, H. suis (and H. pylori) GGT causes an increase of extracellular H 2 O 2 concentrations, generated in a cell-independent manner and causing lipid peroxidation.This leads to different types of cell death, including apoptosis and necrosis/oncosis, depending on the amount of extracellular glutathione available as a GGT substrate.In conclusion, our findings clearly show that, in humans suffering from gastric disease, the possible involvement of NHPH, including H. suis, should not be neglected.
Bimolecular Coupling in Olefin Metathesis: Correlating Structure and Decomposition for Leading and Emerging Ruthenium−Carbene Catalysts (2021)

Bimolecular catalyst decomposition is a fundamental, long-standing challenge in olefin metathesis. Emerging ruthenium-cyclic(alkyl)(amino)carbene (CAAC) catalysts, which enable breakthrough advances in productivity and general robustness, are now known to be extraordinarily susceptible to this pathway. The details of the process, however, have hitherto been obscure. The present study provides the first detailed mechanistic insights into the steric and electronic factors that govern bimolecular decomposition. Described is a combined experimental and theoretical study that probes decomposition of the key active species, RuCl<sub>2</sub>(L)(py)(═CH<sub>2</sub>) <b>1</b> (in which L is the N-heterocyclic carbene (NHC) H<sub>2</sub>IMes, or a CAAC ligand: the latter vary in the NAr group (NMes, N-2,6-Et<sub>2</sub>C<sub>6</sub>H<sub>3</sub>, or N-2-Me,6-<i><sup>i</sup></i>PrC<sub>6</sub>H<sub>3</sub>) and the substituents on the quaternary site flanking the carbene carbon (i.e., CMe<sub>2</sub> or CMePh)). The transiently stabilized pyridine adducts <b>1</b> were isolated by cryogenic synthesis of the metallacyclobutanes, addition of pyridine, and precipitation. All are shown to decompose via second-order kinetics at -10 °C. The most vulnerable CAAC species, however, decompose more than 1000-fold faster than the H<sub>2</sub>IMes analogue. Computational studies reveal that the key factor underlying accelerated decomposition of the CAAC derivatives is their stronger trans influence, which weakens the Ru-py bond and increases the transient concentration of the 14-electron methylidene species, RuCl<sub>2</sub>(L)(═CH<sub>2</sub>) <b>2</b>. Fast catalyst initiation, a major design goal in olefin metathesis, thus has the negative consequence of accelerating decomposition. Inhibiting bimolecular decomposition offers major opportunities to transform catalyst productivity and utility, and to realize the outstanding promise of olefin metathesis.
Fermi surface of a disorderedCu−Al-alloy single crystal studied by high-resolution Compton scattering and electron diffraction (2004)

We have measured high resolution Compton scattering profiles for momentum transfer along a series of 28 independent directions from ${\mathrm{Cu}}_{0.842}{\mathrm{Al}}_{0.158}$ disordered alloy single crystals with normals to the surfaces oriented along the [100], [110], and [111] directions. The experimental spectra are interpreted via parallel first-principles KKR-CPA (Korringa-Kohn-Rostoker coherent-potential approximation) computations of these directional profiles. The Fermi surface determined by inverting the Compton data is found to be in good agreement with the KKR-CPA predictions. An electron diffraction study of the present ${\mathrm{Cu}}_{0.842}{\mathrm{Al}}_{0.158}$ sample is additionally undertaken to gain insight into short-range ordering effects. The scattering pattern displays not only the familiar diffuse scattering peaks, but also shows the presence of weak streaks interconnecting the four diffuse scattering spots around the (110) reciprocal lattice points. This study provides a comprehensive picture of the evolution of the shape of the Fermi surface of $\mathrm{Cu}$ with the addition of $\mathrm{Al}$. Our results are consistent with the notion that Fermi surface nesting is an important factor in driving short-range ordering effects in disordered alloys.
Emotion: Instructions to authors. (2003)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Remedial Surgery Following Failed Gastroplasty for Morbid Obesity (1983)

Gastroplasty (GP) or gastric bypass with exclusion of 90% of the distal stomach (GBP) have largely replaced small bowel bypass in the surgical management of morbid obesity. Despite the theoretical advantages of GP over GBP, revision rates of up to 20% are reported with GP because of unsatisfactory weight loss resulting from staple line disruption, pouch dilatation, and/or stomal enlargement. This report describes four alternative surgical approaches to failed GP. "Complete" partitioning of the stomach accompanied by gastrogastrostomy or conversion to Roux-en-Y GBP is recommended. Because of intangible advantages associated with exclusion of the stomach and duodenum, conversion to GBP is favored over GP revision in such cases.
Near 100% efficient fibre microlenses (1992)

Microlenses have been fabricated directly on the ends of optical fibres which demonstrate 90% (−0.45 dB) coupling efficiencies to semiconductor lasers. The lenses are made by laser micromachining a spinning fibre in a microlathe arrangement. Theoretically, it is possible to collect nearly 100% of the laser radiation with the aspheric lens design presented.
Contributors (2006)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Exotic eigenvalues of shrinking metric graphs (2023)

Eigenvalue spectrum of the Laplacian on a metric graph with arbitrary but fixed vertex conditions is investigated in the limit as the lengths of all edges decrease to zero at the same rate. It is proved that there are exactly four possible types of eigenvalue asymptotics. The number of eigenvalues of each type is expressed via the index and nullity of a form defined in terms of the vertex conditions.
Design of Single-Branch Laminated Waveguide Diplexers Using Modal Orthogonality (2013)

This paper develops novel laminated waveguide diplexers by taking advantage of the modal orthogonality of multiple cavity modes. The uplink and downlink channels of the diplexer can share a common filter structure, which minimizes the number of the cavities. The feeding probes and coupling slots are adequately located to achieve the required coupling coefficients and external quality factors at both passbands simultaneously. In this way, the matching network, i.e., T-junction, adopted in the traditional diplexer design can be eliminated. In addition, by the symmetric but orthogonal field distributions of two operation modes, nearly 30 dB of isolation can be achieved even by sharing the common cavities. The cavities are vertically stacked in low-temperature cofired ceramic technology, which further miniaturizes the circuit size. Two diplexers with third-order Chebyshev responses are designed and fabricated with different operation modes to show the flexibility in the band allocation. Experimental and simulated results are presented, both validating the design concept of the proposed diplexers.
Achieving Reversible Sensing of Nitroxyl by Tuning the Ligand Environment of Azamacrocyclic Copper(II) Complexes (2016)

To elucidate the factors that impart selectivity for nitroxyl (HNO) over nitric oxide (NO), thiols, and H2S in metal-based fluorescent probes, we investigated five Cu(II)-cyclam (14-N4) derivatives. Upon exposure to NO gas at pH 7, no changes occur in the UV-vis spectra of any of the complexes. Addition of Angeli's salt to generate HNO promotes reduction of Cu(II) only in the case of [Cu(II)(14-N4-Ts)(OTf)2], which has the most positive reduction potential of the series. To gain insight into the observed reactivity, we prepared the Cu(II) complex of the mixed thia/aza 14-N2S2 ligand. [Cu(II)(14-N2S2)(OTf)2] reacts reversibly with HNO at pH 7, although nonselectively over thiols and H2S. The recurrent sensing of HNO uncovered with the study of Cu(II) azamacrocyclic complexes is a remarkable feature that opens the door for the design of a new generation of metal-based probes.
Multiband RF Front-End in LTCC for Avionic Systems (2021)

A receiver architecture relying on special RF front-end filtering to separate different services is proposed in which a dual band-pass filter and a dual band coupler are required enabling a multi-standard multi-service direct conversion receiver covering the VHF and UHF avionic services. RF front-end integration is fabricated in low temperature co- fired ceramic (LTCC) technology using a lumped element approach. The overall size of the integration is 59mm&#x00D7;38mm&#x00D7;2.2mm.
Evidence for an Ongoing Role of Class I Histocompatibility Molecules for the Production of Interleukin‐2 in Response to Suboptimal Concentrations of Phytohaemagglutinin (1993)

To examine the role of cellular interactions involving class I histocompatibility antigens in the response to low concentrations of phytohaemagglutinin, we studied the effect of antibodies to components of these antigens on proliferative responses, interleukin-1 and interleukin-2 production, and IL-2 receptor expression. Antibody to human beta 2-microglobulin (beta 2m) had an inhibitory effect both on IL-2 accumulation at 48 h of culture and on the proliferative response 24 h later. Exogenous IL-2 completely reconstituted the inhibited proliferative responses, and also restored the modest decrease in IL-2 receptor expression that was induced by anti-beta 2m. Pretreatment of either purified monocytes or T cells with anti-beta 2m had a similar inhibitory effect both on proliferation and on interleukin-2 production. By contrast, IL-1 production by LPS- or silica-stimulated monocytes was not affected by this antibody. Kinetic experiments demonstrated that anti-beta 2m was equally inhibitory when added at the initiation of culture or after 24h, and significant inhibition occurred when the antibody was added as late as 48 h. Our results are consistent with an ongoing role for class I antigens in the cellular interactions between lymphocytes and accessory cells required for the production of IL-2.
Synthesis layered material of MnO2and TiO2as the support of molybdenum catalyst for bio-crude oil upgrading process (2021)

Abstract Layered materials are attractive for many applications because of their unique structure consisting of stacked sheets that can be controlled and modified. In this work, various synthetic layered materials (SLMs) i.e. , Na-MnO 2 , H-MnO 2 , and Cs-TiO 2 have been successfully prepared as the support for molybdenum (Mo)-based catalyst and applied for bio-crude oil hydrodeoxygenation (HDO) process. A commercial Mo/Al 2 O 3 catalysts will also be utilized as a benchmark. The physical and chemical properties of the catalysts were characterized by using an X-ray diffractometer, X-ray fluorescence, surface area analyzer, NH 3 -temperature-programmed desorption, and scanning electron microscopy. The characterization results showed that the interlayer ion exchange of Na + ions with H + ions was successful for MnO 2 support. The impregnation of the MoO 3 into SLMs increased the surface area, pore-volume, average pore size, and total acidity. The HDO of bio-crude oil using MoO 3 /Na-MnO 2 catalyst produced a higher HHV value of 38.75 MJ/Kg and a DOD value of 82.75% compared to other prepared catalysts or even the MoO 3 commercial catalyst.