gebhart/patrepeval huggingface dataset:
Pollen-food allergy syndrome and component sensitization in adolescents: A Japanese population-based study (2021)

Allergic rhino-conjunctivitis with pollen allergy has been prevalent worldwide and Pollen-food allergy syndrome (PFAS) refers to individuals with pollen allergy who develop oral allergy syndrome (OAS) on consuming fruits and vegetables. The prevalence of PFAS varies by region and that in Japanese adolescents remains to be elucidated. In this cross-sectional study, we examined the epidemiological characteristics of PFAS in a general population of Japanese adolescents according to pollen allergy, OAS, and IgE component sensitization. Participants comprised adolescents, at age 13 years, from a prospective birth cohort study in Japan. We administered questionnaires to collect information from parents regarding pollen allergy, PFAS and OAS at each child's age 13 years. ImmunoCAP ISAC was used to assess IgE component sensitization. Among 506 participants with a complete questionnaire and ISAC measurement results, 56.5% had a history of hay fever, 16.0% had a history of OAS, 51.0% had pollen allergy, and 11.7% had a history of PFAS; additionally, 72.7% were sensitized to one or more tree, grass, and/or weed allergens. The most common sensitization (95.7%) among adolescents with pollen allergy was to Japanese cedar (Cry j 1). The most common causal foods were kiwi and pineapple (both 39.0%). Knowledge levels about PFAS were poor among affected adolescents. We found a high prevalence of PFAS among adolescents in Japan. Although it affects approximately 1/10 adolescents in the general population, public awareness regarding PFAS is poor. Interventional strategies are needed to increase knowledge and to prevent PFAS in the general population.
Alternating Electric Fields for the Treatment of Glioblastoma (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
KU-32, a Novel Drug for Diabetic Neuropathy, Is Safe for Human Islets and ImprovesIn VitroInsulin Secretion and Viability (2012)

KU-32 is a novel, novobiocin-based Hsp90 inhibitor that protects against neuronal glucotoxicity and reverses multiple clinical indices of diabetic peripheral neuropathy in a rodent model. However, any drug with potential for treating diabetic complications must also have no adverse effects on the function of pancreatic islets. Thus, the goal of the current study was to assess the effect of KU-32 on the in vitro viability and function of human islets. Treating human islets with KU-32 for 24 hours showed no toxicity as assessed using the alamarBlue assay. Confocal microscopy confirmed that with a minimum of 2-day exposure, KU-32 improved cellular viability by blocking apoptosis. Functionally, isolated human islets released more glucose-stimulated insulin when preincubated in KU-32. However, diabetic BKS-db/db mice, a model for type 2 diabetes, administered KU-32 for 10 weeks did not show any significant changes in blood glucose and insulin levels, despite having greater insulin staining/beta cell in the pancreas compared to untreated BKS db/db mice. In summary, KU-32 did not harm isolated human islets and may even be protective. However, the effect does not appear significant enough to alter the in vivo metabolic parameters of diabetic mice.
Measurement of concentrator solar cell series resistance by flash testing (1980)

A simple technique for the measurement of series resistance of concentrator solar (photovoltaic) cells is described. This technique makes use of the fact that the ’’short circuit’’ current of a solar cell as a function of light intensity will begin to saturate at an intensity determined by the series resistance of the cell and circuit. In this region the series resistance of the cell can easily be found from a measurement which is relatively independent of illumination intensity and spectrum. Experimental data are presented that verify this result.
Performance of radial basis functions in decodingarecently proposed chaotic modulation strategy (1995)

The use of radial basis functions for decoding a recently proposed modulation strategy is investigated. A range of data signals are considered and practical aspects are discussed when predicting, what in practice would be, a multitude of mapping and decoding parameters. The authors show that radial basis functions do not predict the next unmodulated chaotic sample with the degree of accuracy required to accurately decode a modulating signal. The authors therefore conclude that the proposed modulation technique, together with many other desirable features, results in secure transmission.
MATS; A novel, rapid method for the development of microsatellite markers from YACs (1994)

The availability of high resolution genetic maps has enabled the rapid mapping of a large number of disease loci. In absence of good candidate genes, the eventual identification of the disease locus requires effective strategies for completing the positional cloning {open_quotes}end game{close_quotes}. An essential element of this exercise is the development of local high resolution genetic maps, enabling the precise localization of the minimal interval containing the targeted gene. In addition, one also requires an accurate clone map of this minimal interval. Currently, clone coverage can be obtained using YACs, but rapid development of new genetic markers or additional STSs for walking or confirmation of clone order is a tedious process. Here we describe the successful application of a novel, rapid and efficient procedure, based on subtractive hybridization and PCR amplification for generating microsatellite markers on non-polymorphic STSs directly from the YACs or other large insert cloning vectors. After a single round of subtraction, the target sequences (YAC) are amplified by PCR and cloned into plasmid vectors. Several key steps have been designed to achieve efficient subtractive hybridization and to obtain preferential amplification of the target sequences. These technical steps include the design of novel adapters, PCR primers, efficient developmentmore » of small insert libraries and non-radioactive screening methods. For example, using a 600 kb YAC as a target, we developed 14 new microsatellite markers. These new markers greatly facilitated genetic localization of a disease locus and allowed the accurate ordering by STS content mapping of a cloned contig spanning the interval. In addition to the utility of this approach in positional cloning, this strategy may provide an approach for filling gaps in the emerging genetic maps.« less
Neutralizing Antibodies and Secondary Therapy Failure After Treatment With Botulinum Toxin Type A (2009)

Our results indicate that although NAb formation does play a role in secondary treatment failure with BoNT-A, this is not the cause in all patients, and the influence of other factors needs to be investigated. Gaining a better understanding of the underlying mechanisms for secondary treatment failure may help in the prediction, diagnosis, management, and prevention of this problem.
Abstract 067: Predictors of High-sensitivity C-reactive Protein Elevation Among Patients With Myocardial Infarction: Insights From VIRGO and TRIUMPH (2017)

Background: Elevated hs-CRP is associated with worse cardiovascular outcomes in patients with acute myocardial infarction (AMI), but little is known about predictors of elevated hs-CRP after AMI. Methods: TRIUMPH and VIRGO are prospective AMI registries that assessed hs-CRP levels 30 days after AMI. TRIUMPH assessed hs-CRP levels at 6 months. Multivariable regression analysis was conducted to examine predictors of elevated hs-CRP [≥2.0 mg/L] at 30 days and at 6 months after an AMI (TRIUMPH only). Results: Of 3410 patients in both registries, 58.6% had elevated hs-CRP 30 days post AMI. Patients with elevated hs-CRP were more likely to be female, black, obese, smokers, to have had higher LDL-C at the time of their AMI, with more peripheral vascular disease and history of heart failure, and were less likely to have had a prior PCI (Table). In TRIUMPH, baseline hs-CRP ≥2 mg/L (n=1301) was significantly associated with elevated hs-CRP at 6 months (p&lt;0.001). Patients with elevated hs-CRP at 6 months (n=407) were more likely to be black, obese, smokers, have peripheral vascular disease and have higher baseline hs-CRP. Conclusions: hs-CRP remains elevated in a large proportion of patients following AMI. We identified several predictors of elevated hs-CRP at 1 and 6 months post AMI. Further studies are needed to validate the findings and understand the utility of routine screening of hs-CRP in post AMI patients.
Synthesis of Chiral Methyl Cucurbate and Its Analogs. (1991)

Natural ( + )-(l /?,25' ,3S)-methyl cucurbate (lb) and the ( -)-<5-lactone of 3-epi-cucurbic acid (16) were synthesized from ( + )-(l/?,6S,7/?)-bicyclo[4.3.0]non-3-en-7-ol (5). Asymmetric hydrolysis of the acetate (8) of ( +)-5 with pancreatin gave optically pure the (+)-(7/?)-alcohol ( An ozonolysis product of (+)-5 was transformed to (-)-16 and (+)-( Similarly, unnatural (-)-lb and (+)-16 were prepared from optically pure (-)-5. The growth inhibitory activities of these synthesized chiral compounds toward lettuce seedlings were examined.
Dynamic configuration of resource-aware services (2004)

An important emerging requirement for computing systems is the ability to adapt at run time, taking advantage of local computing devices, and coping with dynamically changing resources. Three specific technical challenges in satisfying this requirement are to (1) select an appropriate set of applications or services to carry out a user's task, (2) allocate (possibly scarce) resources among those applications, and (3) reconfigure the applications or resource assignments if the situation changes. In this paper, we show how to provide a shared infrastructure that automates configuration decisions given a specification of the user's task. The heart of the approach is an analytical model and an efficient algorithm that can be used at run time to make near-optimal (re)configuration decisions. We validate this approach both analytically and by applying it to a representative scenario.
Cleartext JSON Web Encryption (JWE) (2018)

Cleartext JSON Web Encryption (JWE) is a means of representing
encrypted content as a JSON object without representing JSON values to
be integrity protected in a non-JSON representation, such as
base64url-encoded JSON. The integrity protection calculation for the
authenticated encryption performed uses the predictable JSON
serialization defined in ECMAScript version 6. Cleartext JWE builds on
the JWE, JWA, and JWK specifications, reusing data structures and
semantics from these specifications, where applicable.
Dye attached poly(hydroxyethyl methacrylate) cryogel for albumin depletion from human serum (2012)

Cibacron Blue F3GA was immobilized on poly(hydroxyethyl methacrylate) cryogel and it was used for selective and efficient depletion of albumin from human serum. The poly(hydroxyethyl methacrylate) was selected as the basic component because of its inertness, mechanical strength, chemical and biological stability, and biocompatibility. Cibacron Blue F3GA was covalently attached to the poly(hydroxyethyl methacrylate) cryogel to produce poly(hydroxyethyl methacrylate)-Cibacron Blue F3GA cryogel affinity column. The poly(hydroxyethyl methacrylate)-Cibacron Blue F3GA cryogel was characterized with respect to gelation yield, swelling degree, total volume of macropores, Fourier Transform Infrared spectroscopy, and scanning electron microscopy. It was found that the maximum amount of adsorption (343 mg/g of dry cryogel) obtained from experimental results is very close to the calculated Langmuir adsorption capacity (345 mg/g of dry cryogel). The maximum adsorption capacity for poly(hydroxyethyl methacrylate)-Cibacron Blue F3GA cryogel column was obtained as 950 mg/g of dry cryogel for nondiluted serum. The adsorption capacity decreased with increasing dilution ratios while the depletion ratio of albumin remained as 77% in serum sample. Finally, the poly(hydroxyethyl methacrylate)-Cibacron Blue F3GA cryogel was optimized for using in the fast protein liquid chromatography system for rapid removal of the high abundant proteins from the human serum.
Retinoic Acid Is Essential for Th1 Cell Lineage Stability and Prevents Transition to a Th17 Cell Program (2015)

CD4(+) T cells differentiate into phenotypically distinct T helper cells upon antigenic stimulation. Regulation of plasticity between these CD4(+) T-cell lineages is critical for immune homeostasis and prevention of autoimmune disease. However, the factors that regulate lineage stability are largely unknown. Here we investigate a role for retinoic acid (RA) in the regulation of lineage stability using T helper 1 (Th1) cells, traditionally considered the most phenotypically stable Th subset. We found that RA, through its receptor RARα, sustains stable expression of Th1 lineage specifying genes, as well as repressing genes that instruct Th17-cell fate. RA signaling is essential for limiting Th1-cell conversion into Th17 effectors and for preventing pathogenic Th17 responses in vivo. Our study identifies RA-RARα as a key component of the regulatory network governing maintenance and plasticity of Th1-cell fate and defines an additional pathway for the development of Th17 cells.
Public Opinion Research in France (1952)

Public opinion research in France, its development arrested by the war and the German invasion, has made significant forward strides since 1945. The author here describes the present organization and focus of this research, and discusses the problems—special and generic—which limit its further evolution. Principal among these are chronic shortages of funds, personnel, and facilities for academic training. In spite of these difficulties, the author finds that French research methods demonstrate considerable ingenuity and technical sophistication. Mr. Dorsey is a graduate student in political science at the University of Alabama. The material for this article was gathered while the author was in Paris on a Fulbright scholarship.
The Portals 4.1 Network Programming Interface (2017)

This report presents a specification for the Portals 4 networ k programming interface. Portals 4 is intended to allow scalable, high-performance network communication betwee n nodes of a parallel computing system. Portals 4 is well suited to massively parallel processing and embedded syste ms. Portals 4 represents an adaption of the data movement layer developed for massively parallel processing platfor ms, such as the 4500-node Intel TeraFLOPS machine. Sandia's Cplant cluster project motivated the development of Version 3.0, which was later extended to Version 3.3 as part of the Cray Red Storm machine and XT line. Version 4 is tar geted to the next generation of machines employing advanced network interface architectures that support enh anced offload capabilities.
Supplementary Material for: Proteomic Investigation of the Hippocampus in Prenatally Stressed Mice Implicates Changes in Membrane Trafficking, Cytoskeletal, and Metabolic Function (2017)

Prenatal stress influences the development of the fetal brain and so contributes to the risk of the development of psychiatric disorders in later life. The hippocampus is particularly sensitive to prenatal stress, and robust abnormalities have been described in the hippocampus in schizophrenia and depression. The aim of this study was to determine whether prenatal stress is associated with distinct patterns of differential protein expression in the hippocampus using a validated mouse model. We therefore performed a comparative proteomic study assessing female hippocampal samples from 8 prenatally stressed mice and 8 control mice. Differential protein expression was assessed using 2-dimensional difference in gel electrophoresis and subsequent mass spectrometry. The observed changes in a selected group of differentially expressed proteins were confirmed by Western blotting. In comparison to controls, 47 protein spots (38 individual proteins) were found to be differentially expressed in the hippocampus of prenatally stressed mice. Functional grouping of these proteins revealed that prenatal stress influenced the expression of proteins involved in brain development, cytoskeletal composition, stress response, and energy metabolism. Western blotting was utilized to validate the changes in calretinin, hippocalcin, profilin-1 and the signal-transducing adaptor molecule STAM1. Septin-5 could not be validated via Western blotting due to methodological issues. Closer investigation of the validated proteins also pointed to an interesting role for membrane trafficking deficits mediated by prenatal stress. Our findings demonstrate that prenatal stress leads to altered hippocampal protein expression, implicating numerous molecular pathways that may provide new targets for psychotropic drug development.
Feeding Value of Leaf Meal of Acacia on Poultry Feed (1980)

Feeding value of the leaf meal of acacia (Robinia Pseudoacacia. L) which was produced in China as a poultry feed was compared with that of the dehydrated alfalfa meal.In the first experiment, chemical composition and metabolizable energy value of the leaf meal were determined. The results were as follows: Crude protein 19.7%, Crude fat 3.5%, Crude fiber 10.2%, Crude ash 12.1%, Calcium 2.1%, Phosphorus 0.2%, total carotenoid 28.2mg/100g and metabolizable energy value 1074kcal per kg feed.In the second experiment, 64 broiler chicks were fed a corn-soybean type diet containing 5 percent of leaf meal, and another 64 chicks a diet containing the same level of dehydrated alfalfa meal. Body weight gain, feed intake and mortality were recorded. The results showed no difference between two groups.In the third experiment, colouring effect of the leaf meal carotenoid on egg yolk was studied. The egg yolk pigmenting efficiency of the leaf meal was almost the same as that of dehydrated alfalfa meal. The relative egg yolk pigmenting efficiency of the leaf meal determined on the basis of yellow corn was 84.
Efficient work-function engineering of solution-processed MoS2 thin-films for novel hole and electron transport layers leading to high-performance polymer solar cells (2013)

The work-function of MoS2 interfacial layers can be efficiently modulated by p- and n-doping treatments. As a result, the PCE of devices with a p-doped MoS2-based HTL is increased from ∼2.8 to ∼3.4%. Particularly, after n-doping the PCE was dramatically increased due to the change in work-function compared with un-doped MoS2 thin-films.
GroupICA dual regression analysis of resting state networks in a behavioral variant of frontotemporal dementia (2013)

Functional MRI studies have revealed changes in default-mode and salience networks in neurodegenerative dementias, especially in Alzheimer's disease (AD). The purpose of this study was to analyze the whole brain cortex resting state networks (RSNs) in patients with behavioral variant frontotemporal dementia (bvFTD) by using resting state functional MRI (rfMRI). The group specific RSNs were identified by high model order independent component analysis (ICA) and a dual regression technique was used to detect between-group differences in the RSNs with p < 0.05 threshold corrected for multiple comparisons. A y-concatenation method was used to correct for multiple comparisons for multiple independent components, gray matter differences as well as the voxel level. We found increased connectivity in several networks within patients with bvFTD compared to the control group. The most prominent enhancement was seen in the right frontotemporal area and insula. A significant increase in functional connectivity was also detected in the left dorsal attention network (DAN), in anterior paracingulate-a default mode sub-network as well as in the anterior parts of the frontal pole. Notably the increased patterns of connectivity were seen in areas around atrophic regions. The present results demonstrate abnormal increased connectivity in several important brain networks including the DAN and default-mode network (DMN) in patients with bvFTD. These changes may be associated with decline in executive functions and attention as well as apathy, which are the major cognitive and neuropsychiatric defects in patients with frontotemporal dementia.
First-in-Humans Brain PET Imaging of the GluN2B-ContainingN-methyl-d-aspartate Receptor with (R)-11C-Me-NB1 (2021)

The <i>N</i>-methyl-d-aspartate receptor (NMDAR) plays a crucial role in neurodegenerative diseases such as Alzheimer disease and in the treatment of major depression by fast-acting antidepressants such as ketamine. Given their broad implications, GluN2B-containing NMDARs have been of interest as diagnostic and therapeutic targets. Recently, (<i>R</i>)-<sup>11</sup>C-Me-NB1 was investigated preclinically and shown to be a promising radioligand for imaging GluN2B subunits. Here, we report on the performance characteristics of this radioligand in a first-in-humans PET study. <b>Methods:</b> Six healthy male subjects were scanned twice on a fully integrated PET/MR scanner with (<i>R</i>)-<sup>11</sup>C-Me-NB1 for 120 min. Brain uptake and tracer distribution over time were investigated by SUVs. Test-retest reliability was assessed with the absolute percentage difference and the coefficient of variation. Exploratory total volumes of distribution (V<sub>T</sub>) were computed using an arterial input function and the Logan plot as well as a constrained 2-tissue-compartment model with the ratio of rate constants between plasma and tissue compartments (<i>K</i><sub>1</sub>/<i>k</i><sub>2</sub>) coupled (2TCM). SUV was correlated with V<sub>T</sub> to investigate its potential as a surrogate marker of GluN2B expression. <b>Results:</b> High and heterogeneous radioligand uptake was observed across the entire gray matter with reversible kinetics within the scan time. SUV absolute percentage difference ranged from 6.9% to 8.5% and coefficient of variation from 4.9% to 6.0%, indicating a high test-retest reliability. A moderate correlation was found between SUV averaged from 70 to 90 min and V<sub>T</sub> using Logan plot (Spearman ρ = 0.44). Correlation between V<sub>T</sub> Logan and 2TCM was <i>r</i> = 0.76. <b>Conclusion:</b> The radioligand (<i>R</i>)-<sup>11</sup>C-Me-NB1 was highly effective in mapping GluN2B-enriched NMDARs in the human brain. With a heterogeneous uptake and a high test-retest reliability, this radioligand offers promise to deepen our understanding of the GluN2B-containing NMDAR in the pathophysiology and treatment of neuropsychiatric disease such as Alzheimer disease and major depression. Additionally, it could help in the selection of appropriate doses of GluN2B-targeting drugs.