gebhart/patrepeval huggingface dataset:
Decreased Levels of BAG3 in a Family With a Rare Variant and in Idiopathic Dilated Cardiomyopathy (2014)

The most common cause of dilated cardiomyopathy and heart failure (HF) is ischemic heart disease; however, in a third of all patients the cause remains undefined and patients are diagnosed as having idiopathic dilated cardiomyopathy (IDC). Recent studies suggest that many patients with IDC have a family history of HF and rare genetic variants in over 35 genes have been shown to be causative of disease. We employed whole-exome sequencing to identify the causative variant in a large family with autosomal dominant transmission of dilated cardiomyopathy. Sequencing and subsequent informatics revealed a novel 10-nucleotide deletion in the BCL2-associated athanogene 3 (BAG3) gene (Ch10:del 121436332_12143641: del. 1266_1275 [NM 004281]) that segregated with all affected individuals. The deletion predicted a shift in the reading frame with the resultant deletion of 135 amino acids from the C-terminal end of the protein. Consistent with genetic variants in genes encoding other sarcomeric proteins there was a considerable amount of genetic heterogeneity in the affected family members. Interestingly, we also found that the levels of BAG3 protein were significantly reduced in the hearts from unrelated patients with end-stage HF undergoing cardiac transplantation when compared with non-failing controls. Diminished levels of BAG3 protein may be associated with both familial and non-familial forms of dilated cardiomyopathy.
Arabidopsis Lateral Root Development 3 is essential for early phloem development and function, and hence for normal root system development (2011)

We have identified a gene, Lateral Root Development 3 (LRD3), that is important for maintaining a balance between primary and lateral root growth. The lrd3 mutant has decreased primary root growth and increased lateral root growth. We determined that the LRD3 gene encodes a LIM-domain protein of unknown function. LRD3 is expressed only in the phloem companion cells, which suggested a role in phloem function. Indeed, while phloem loading and export from the shoot appear to be normal, delivery of phloem to the primary root tip is limited severely in young seedlings. Abnormalities in phloem morphology in these seedlings indicate that LRD3 is essential for correct early phloem development. There is a subsequent spontaneous recovery of normal phloem morphology, which is correlated tightly with increased phloem delivery and growth of the primary root. The LRD3 gene is one of very few genes described to affect phloem development, and the only one that is specific to early phloem development. Continuous growth on auxin also leads to recovery of phloem development and function in lrd3, which demonstrates that auxin plays a key role in early phloem development. The root system architecture and the pattern of phloem allocation in the lrd3 root system suggested that there may be regulated mechanisms for selectively supporting certain lateral roots when the primary root is compromised. Therefore, this study provides new insights into phloem-mediated resource allocation and its effects on plant root system architecture.
Effects of pharmacist participation in chronic kidney disease (CKD) network and CKD manual distribution on drug‐related kidney injury (2019)

Pharmacist participation in the CKD network and CKD manual distribution decreased both hospitalizations due to RAS inhibitor-related kidney injury and citizens with CKD stage G3a-3b.
PD-1 Blockade in Advanced Melanoma in Patients with Hepatitis C and/or HIV (2015)

On the basis of remarkable antitumor activity, programmed death receptor-1 (PD-1) inhibitors pembrolizumab and nivolumab were approved for the treatment of advanced melanoma in the second-line setting following progression on either CTLA-4 inhibitor ipilimumab or BRAF/MEK inhibitors (for BRAF mutated melanoma). Given hypothesized risk of triggering exacerbations of autoimmune diseases and/or chronic viral infections, clinical trials (including regulatory studies) evaluating checkpoint blocking antibodies PD-1 and CTLA-4 have excluded patients with autoimmune diseases, chronic hepatitis B/C virus (HBV/HCV), and/or human immunodeficiency virus (HIV) infections. Herein, we describe two patients with advanced melanoma and concomitant HCV/HIV infections treated with PD-1 inhibitor pembrolizumab. Patient 2 with HIV/HCV coinfection progressed after 2 doses of pembrolizumab. Patient 1 who had HCV alone was treated with pembrolizumab with initial partial response. HCV viral load remained stable after 9 cycles of pembrolizumab following which 12-week course of HCV-directed therapy was commenced, resulting in prompt reduction of HCV viral load below detectable levels. Response is ongoing and HCV viral load remains undetectable. In both patients, no significant toxicities were observed when pembrolizumab was initiated. We argue for the further investigation of checkpoint inhibition in cancer patients with underlying chronic viral infections in the context of carefully designed clinical trials.
X-ray production ~13 nm from laser-produced plasmas for projection x-ray lithography applications (1993)

X-ray production in the region ˜ 13 nm from laser-produced plasmas has been investigated as a source for projection x-ray lithography. The dependence of x-ray conversion efficiency on target material, intensity, and pulse length has been studied by using a 0.53-µm laser with a maximum of 0.3 J. A conversion efficiency of 1% into a 0.3-nm bandwidth has been demonstrated for Sn targets at intensities of ˜ 10(11) W/cm(2) by using a 7.5-ns pulse. Intensity scaling suggests that laser spot size and two-dimensional expansion are important for optimizing x-ray production at these low-irradiation intensities.
Tests show production logging problems in horizontal gas wells (1994)

A study has concluded that production logging tools employed to evaluate multiphase horizontal well production behavior should be carefully screened as to their response characteristics in fully-segregated, two-phase flow. The study, performed at Marathon Oil Co.'s petroleum technology center in Littleton, Colo., indicated that gas in highly deviated well bores segregates rapidly in the presence of water, creating a downhole environment that produces sporadic responses from full bore and diverter spinners as well as density and holdup tools. Gas Research Institute (GRI), as part of its horizontal gas well completion technology program, initiated the full-scale laboratory study to determine the severity and consequences of multiphase flow on tool response from horizontal well production. The paper discusses background of the problem, the test objectives, test facility, experimental procedures, single-phase flow, two-phase flow, and recommendations.
Drastic Widening the Bandwidth of Ferrite Electromagnetic Wave Absorbers (2005)

Characteristics of novel electromagnetic wave absorbers, multilayered and grid structures, are discussed. They have wide bandwidth for low reflection, e.g., from 30 to 1830 MHz for reflection -20dB in a threelayered absorber. They are also effective to reduce the thickness of lossy dielectric in constructing ultrawide band absorbers.
Effect of Wet-Dry Condition on Self-Healing Property of Early-Age ECC (2010)

This paper describes the results of self-healing behavior in early-age Engineered Cementitious Composites (ECC). Uniaxially pre-loaded ECC with tensile strain of 0.3 or 0.5% were subjected to different number of wet-dry cycles. Then, resonant frequency test and reloading test were carried out to assess the recovery rate as a function of the number of wet-dry cycles. These two tests indicated different recovery rates and it was revealed that the number of wet-dry cycles, crack width and dispersion were crucial to attain recovery in mechanical characteristics.
Nutrition and Food Skills Education: For Adults with Developmental Disabilities (2011)

There is a strong interest in and need for nutrition education and food skills programs for adults with developmental disabilities. The collaboration of multiple community partners in program implementation and delivery is essential. At the policy level, the needs of individuals with aging caregivers must be addressed and access to registered dietitians must be improved for this population.
An exploration of the experience of post-natal depression support services in Cork (2013)

This research was carried out of behalf of Post Natal Depression Ireland (PND Ireland) in association with Community Academic Research Links (CARL). This is an initiative in University College Cork (UCC) which works with Civic Society Organisations (CSO) by assisting them with research they wish to pursue. In this case the research will be facilitated by two final year Bachelor of Social Work (BSW) students. The research explores the experiences of support services for mothers with post-natal depression in Cork. The research is a qualitative study based on interviews with mothers who have or had post-natal depression (PND) and professional support service providers. To facilitate this research a literature review of the social and medical constructions of post-natal depression was conducted. A previous study undertaken by (CARL) on behalf of PND Ireland in 2012, revealed the prevalence of PND and the importance of peer and professional supports in reducing the symptoms of PND. This study will make a distinctive contribution to research into how PND support services are experienced by mothers in Cork. In conducting personal interviews it will allow a depth of analysis based on the lived experiences of the mothers interviewed. It aims to identify what supports mothers with PND had access to, both professional and social supports, and whether the supports were beneficial or not. Building on this knowledge of what services are available the researchers seek to identify why support services are experienced in the manner in which they are.
Spectroscopy for Solid-State Optical Masers (1962)

A brief account is given of the spectroscopy of excitation processes in semiconductors, rare earth ions, transition metal ions, and actinide group ions in ionic crystals, from the standpoint of applying solid-state optical spectra to optical masers.
Space Charge and Electrode Polarization in Glass, II (1964)

This paper is Part IT of a two‐part series reviewing the present understanding of space charge and electrode polarization in glass and the interrelations of these concepts with the usually measured electrical properties of glass. Emphasis is placed on a theory describing the distribution of static space charge in material having only a single mobile charge carrier. Charge dissociation and recombination are considered and the carriers are assumed to move under diffusion and conduction. The charge distributions predicted by the theory are discussed and are compared with the results of experiments which were undertaken specifically to verify essential features of the predictions. The theory is confirmed qualitatively by the observed charge distribution shapes and asymmetries. Quantitative confirmation is also shown in computed values of mobility, diffusion constant, and contact potential ratios. This theory has here been expanded to include a linearized ac treatment, and the phenomena predicted by this treatment fit the known data semi‐quantitatively. A large low‐frequency relaxation mechanism is predicted. Previous theory and experiment were briefly reviewed in Part I. In Part I1 the predicted and observed space charges are conceptually related to various phenomena such as conduction, electrode polarization, dielectric absorption, and dielectric loss. Needed improvements in the present theory and a number of ideas for more experiments are outlined in order to stimulate efforts to acquire a more detailed understanding of these phenomena.
Introduction à la mycothérapie: généralités sur l’intérêt des principaux mycelia (2010)

Les travaux réalisés par les Chinois, les Japonais et les Coréens depuis plus de 30 ans ne laissent aucun doute sur l’intérêt de la mycothérapie. Le mycélium (partie souter-raine du champignon) sera préféré au sporocarpe qui contient des polyamines protumorales, qui risque d’être contaminé ou vieilli et qui ne relargue pas facilement les principes actifs. Les principaux mycelia à connaître sont: Coriolus versicolor (Karawataké), Ganoderma lucidum (Reishi), Grifola frondosa (Maïtaké), Agaricus blazei, Lentinus edodes (shiitaké), Hericium erinaceus, Pleurotus ostreatus, Polyporus umbellatus, Armillaria mellea, Phellinus linteus. La plupart stimulent l’immunité, mais chacun présente des spécificités et mérite un article spécifique. Cet article expose les généralités indispensables à la mycothérapie.
[Cp*RhCl2]2: mechanosynthesis and applications in C–H bond functionalisations under ball-milling conditions (2015)

A mechanochemical synthesis of [Cp*RhCl2]2 has been developed. Under LAG conditions the organometallic complex can be prepared in a shorter reaction time compared to the standard solution-based protocol. The obtained Rh(iii) dimer is then applicable as catalyst in subsequent solvent-free mechanochemical C-H bond functionalisations of 2-phenylpyridine.
OPTOFLUIDIC DEVICE FOR HIGH RESOLUTION AND MULTIPARAMETRIC MEASUREMENT OF SINGLE BIOLOGICAL CELLS (2014)

This paper reports a novel optofluidic device providing cellular sub-populations discrimination.
Can Temporal Information Help with Contrastive Self-Supervised Learning? (2020)

Leveraging temporal information has been regarded as essential for developing video understanding models. However, how to properly incorporate temporal information into the recent successful instance discrimination based contrastive self-supervised learning (CSL) framework remains unclear. As an intuitive solution, we find that directly applying temporal augmentations does not help, or even impair video CSL in general. This counter-intuitive observation motivates us to re-design existing video CSL frameworks, for better integration of temporal knowledge. To this end, we present Temporal-aware Contrastive self-supervised learningTaCo, as a general paradigm to enhance video CSL. Specifically, TaCo selects a set of temporal transformations not only as strong data augmentation but also to constitute extra self-supervision for video understanding. By jointly contrasting instances with enriched temporal transformations and learning these transformations as self-supervised signals, TaCo can significantly enhance unsupervised video representation learning. For instance, TaCo demonstrates consistent improvement in downstream classification tasks over a list of backbones and CSL approaches. Our best model achieves 85.1% (UCF-101) and 51.6% (HMDB-51) top-1 accuracy, which is a 3% and 2.4% relative improvement over the previous state-of-the-art.
The application of computers to generate organic syntheses (1997)

A major task of organic chemistry is the synthesis of compounds of interest (“targets”) from available starting compounds. We address here the generation by computer of the best synthesis routes, or sequences of reactions, to such compounds. The number of possible routes in the search space is enormous and so the reasoning is examined in some detail, leading to a protocol for the operation of our program, SYNGEN, which has been under development for some years. It requires a new representation of the data – molecular structures and their reactions – which is digital in format and quite unlike the usual graphical depictions of organic chemistry. This is presented as a problem in artificial intelligence, and every effort has been made to present it with a minimum background of organic chemistry required of the reader.
Nonanal and 6-methyl-5-hepten-2-one. Endogenous germination stimulators of uredospores of Puccinia graminis var tritici and other rusts (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNonanal and 6-methyl-5-hepten-2-one. Endogenous germination stimulators of uredospores of Puccinia graminis var tritici and other rustsHoward W. Rines, Richard C. French, and Lester W. DaaschCite this: J. Agric. Food Chem. 1974, 22, 1, 96–100Publication Date (Print):January 1, 1974Publication History Published online1 May 2002Published inissue 1 January 1974https://pubs.acs.org/doi/10.1021/jf60191a004https://doi.org/10.1021/jf60191a004research-articleACS PublicationsRequest reuse permissionsArticle Views132Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Nitroimidazooxazines (PA-824 and Analogs): Structure–Activity Relationship and Mechanistic Studies (2010)

PA-824 is an experimental anti-tubercular agent that has a novel mechanism of action. It is effective against both active and persistent forms of the disease and has recently shown early bactericidal activity in a Phase II clinical trial. This review summarizes recent studies on the mode of action of PA-824 and outlines successful efforts to prepare more effective second-generation analogs. PA-824 displays unusual chemistry following both enzymatic and radiolytic reduction, which is clearly related to its activity as an anti-tubercular agent. The nitroreductase enzyme deazaflavin-dependent nitroreductase, reduces PA-824 with loss of the nitro group, generating reactive nitrogen species such as nitric oxide, which appear important in mediating the activity of the drug. Bioreductive drugs such as PA-824 hold the promise of shorter treatment regimens.
Supplementary Data File S4 from Metastatic Conditioning of Myeloid Cells at a Subcutaneous Synthetic Niche Reflects Disease Progression and Predicts Therapeutic Outcomes (2023)

&lt;p&gt;Workbook organized into spreadsheets detailing statistical findings for the manuscript including all exact F and p values. Syntax for SPSS analysis is listed at the top of each sheet for subsequent statistical tests.&lt;/p&gt;
Wind Loads (2013)

This helpful guide focuses on the wind load provisions of Minimum Design Loads for Buildings and Other Structures, Standard ASCE/SEI 7-10, that affect the planning, design, and construction of buildings for residential and commercial purposes. The 2010 revision of the Standard significantly reorganized the wind load provisions, expanding them from one to six chapters. Simplified methods of performing calculations for common situations were added to the Standard, and guidelines for components and cladding were gathered in a single chapter.
The equivalence of vacancy-type damage in ion-implanted Si seen by positron annihilation spectroscopy (1999)

The response of the Doppler-broadened annihilation linewidth parameter S to ion dose has been measured using a controllable-energy positron beam for n-type Fz–Si(100) implanted with 120 keV Ge+, 400 keV O+, 200 keV He+, and 450 keV H+ ions. For all ions S increases with dose, indicating the presence of vacancy-type defects. It is found that the maximum S values for the Ge+, O+, and H+ implants can be normalized to one well-defined distribution using values of predicted vacancy concentration from the Monte Carlo code TRIM. This result implies that vacancy-type defects from these three implantations are similar in both structure and interstitial recombination rate. The He+ data do not lie perfectly on the universal distribution; it is suggested that this is a result of defect passivation by the implanted He.
Using Protease Inhibitors in Antigen Presentation Assays (2012)

The major histocompatibility complex (MHC) class I restricted pathway of antigen processing allows the presentation of intracellular antigens to cytotoxic T lymphocytes. The proteasome is the main protease in the cytoplasm and the nucleus, which is responsible for the generation of most peptide ligands of MHC-I molecules. Peptides produced by the proteasome can be further trimmed or destroyed by numerous cytosolic or endoplasmic reticulum (ER) lumenal proteases. Small molecule inhibitors are useful tools for probing the role of proteases in MHC class I antigen processing. Here, we describe different methods to test the impact of protease inhibitors in antigen presentation assays.
Ni1−xPtx (x=0–0.08) films as the photocathode of dye-sensitized solar cells with high efficiency (2009)

Films of Ni1−x Pt x (x=0, 0.02, 0.04, 0.06, and 0.08) have been prepared on fluorine-doped tin oxide-coated (FTO) glass substrates by a chemical plating method and used as the photocathode for dye-sensitized solar cells (DSCs). The Ni0.94Pt0.06 film consisted of nanoparticles with a size of 4–6 nm and a Pt loading of 5.13 μg/cm2. The Ni0.94Pt0.06 photocathode exhibited high catalytic performance toward triiodide reduction, high light reflectance, and low charge-transfer resistance. The DSC assembled with the Ni0.94Pt0.06 photocathode gave a short-circuit photocurrent density (J sc) of 16.79 mA/cm2, an open-circuit photovoltage (V oc) of 736 mV, and a fill factor (FF) of 66.4%, corresponding to an overall conversion efficiency of 8.21% under standard AM 1.5 irradiation (100 mW/cm2), which is higher than that for the DSC with a pure Pt photocathode obtained by conventional thermal decomposition. Furthermore, the DSC based on the Ni0.94Pt0.06 photocathode showed good stability. The results indicate that Ni0.94Pt0.06 films are promising lowcost and high-performance photocathodes for use in DSCs.
Architecture for a Mobile Robotic Camera Positioning System for Photogrammetric Data Acquisition in Hydroelectric Tunnels (2023)

The structural condition of hydroelectric tunnels is important to the overall performance, safety, and longevity of generating stations. Significant effort is required to inspect, monitor, and maintain these tunnels. Photogrammetry is an effective method of collecting highly accurate visual and spatial data. However, it also presents the complex challenge of positioning a camera at thousands of difficult-to-reach locations throughout the large and varying-diameter tunnels. A semi-automated robotic camera positioning system was developed to enhance the collection of images within hydroelectric tunnels for photogrammetric inspections. A continuous spiral image network was developed to optimize the collection speed within the bounds of photography and capture-in-motion constraints. The positioning system and image network optimization reduce the time and effort required while providing the ability to adapt to different and varying tunnel diameters. To demonstrate, over 28,000 images were captured at a ground sampling distance of 0.4 mm in the 822 m long concrete-lined section of the Grand Falls Generating Station intake tunnel.
Local defect correction for the boundary element method (2006)

This paper presents an efficient way to implement the Boundary Element Method (BEM) to capture high activity regions in a boundary value problem.\nIn boundary regions where accuracy is critical, like in adaptive surface meshes, the method of choice is Local Defect Correction (LDC). We formulate the method and demonstrate its applicability and reliability by means of an example. Numerical results show that LDC and BEM together provide accurate solutions with less computational requirements given that BEMsystems usually consist of dense matrices.