gebhart/patrepeval huggingface dataset:
Abstract 15185: Vascular Endothelial Growth Factor Inhibition Results in Systemic Hypertension Mediated by Alterations in Endothelin-1, but Not by Alterations in Nitric Oxide or Reactive Oxygen Species (2011)

Purpose: Inhibition of Vascular Endothelial Growth Factor (VEGF) signaling is an established therapy for various forms of cancer. However, this therapy is associated with hypertension. VEGF signaling enhances NO production, which in turn may reduce endothelin (ET) and scavenge reactive oxygen species (ROS). We therefore hypothesized that hypertension resulting from VEGF inhibition is due to a loss of NO bioavailability and an increase in ROS and/or ET. Methods: On different days, chronically instrumented swine (N=6) received i.v. infusion of either the endothelial NO synthase inhibitor N ω -Nitro-L-arginine (NLA), the ET A /ET B receptor blocker tezosentan or a combination of ROS scavengers (4-Hydroxy-2,2,6,6-Tetramethylpiperidine-1-oxyl, N-Acetyl-Cysteine and N-2-Mercaptoproprionyl-Glycine). Before and after these infusions hemodynamic parameters were recorded. These experiments were repeated after administration of the VEGF-receptor inhibitor sunitinib, 50 mg/day p.o. for 1 week. Results: Sunitinib increased blood pressure and systemic vascular resistance reflecting vasoconstriction (Table). Following sunitinib, the rise in blood pressure and systemic vascular resistance induced by NLA increased, while the changes in blood pressure by ROS scavenging decreased. In contrast, while tezosentan had no effect under control conditions, it resulted in a decrease in blood pressure and systemic vascular resistance following sunitinib. Hence, tezosentan abrogated the sunitinib-induced vasoconstriction. Conclusions: VEGF inhibition results in sustained hypertension. This hypertension is caused by enhanced ET-mediated vasoconstriction, but not by decreased NO-bioavailability or enhanced oxidative stress. These results warrant studies into the efficacy of ET receptor blockade in limiting the hypertensive side effects of VEGF inhibition.
The development of cationic zinc complexes as a new class of lactide polymerization catalyst (2011)

The thesis outlines the development of novel cationic zinc complexes for application in lactide polymerization catalysis. These complexes were characterized spectroscopically and crystallographically, and where appropriate their efficacy as catalysts for the polymerization of lactide was evaluated.
 The strongly donating, neutral chelating ligands employed in this study were prepared by installation of either one or two phosphinimine donors on a dibenzofuran backbone. An efficient synthetic methodology was then developed for the synthesis of cationic complexes of the formula [LZnE+][BAr4-], wherein E = C2H5, CH3, Ph, C6F5, OAc, OC6F5, or methyl-(D,L)-lactate, and AR = Ph, C6F5, or m-(CF3)2-C6H3. Only the cationic zinc-lactate species were found to be highly active polymerization catalysts.
 Tuning of the steric and electronic properties of the ligand resulted in the discovery of zinc-lactate systems that promote rapid and well-controlled polymerization of lactide under mild conditions, marking the first well-defined cationic metal catalysts to do so.
Influence of oxymatrine on cell proliferation and VEGF expression in human gastric cancer cell line SGC-7901 (2010)

Background and purpose:Oxymatrine, which is the main effective component of Sophora flavescens Ait, has anti-fibrosis and antiviral activities, and also has a good effect on leukopenia after either chemotherapy or radiotherapy. Recent studies showed that oxymatrine has the abilities of anti-invasion and killing tumor cells in some degree, and as a supplementary anticancer drug in chemical therapy. In this study, we investigated the antitumor mechanism of oxymatrine by observing cell proliferation and VEGF expression in human gastric cancer SGC-7901 cell line. Methods:Human gastric cancer SGC-7901 cells was cultured in vitro and treated with oxymatrine, then cell proliferation was examined by the method of MTT. Immunohistochemistry was applied to examine the protein expression of VEGF. The transcriptions of VEGF mRNA were demonstrated by RT-PCR technique. Results:Low-dose (0.5 mg/mL) oxymatrine has a mild inhibitory effect on cellular proliferation of SGC-7901 cells (P0.05). When concentration exceeded 1 mg/mL, oxymatrine signifi cantly inhibited cellular proliferation in a time and concentration-dependent manner, and down-regulated the mRNA and protein expression of VEGF (P0.05). Conclusion:Within a certain drug concentration, oxymatrine can inhibit the proliferation of SGC-7901 cells and play a potential role in inhibiting angiogenesis by down-regulating the expression of VEGF.
ChemInform Abstract: Convenient Syntheses of Racemic 2‐(3‐Nitrophenyl)propanoic Acid and 2‐( 3‐Aminophenyl)propanoic Acid. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
New Measurements of High-Momentum Nucleons and Short-Range Structures in Nuclei (2012)

We present new measurements of electron scattering from high-momentum nucleons in nuclei. These data allow an improved determination of the strength of two-nucleon correlations for several nuclei, including light nuclei where clustering effects can, for the first time, be examined. The data also include the kinematic region where three-nucleon correlations are expected to dominate.
Limited feedback precoding for orthogonal space-time block codes (2005)

Orthogonal space-time block codes (OSTBCs) are an efficient solution for obtaining full diversity order in Rayleigh fading channels. Unfortunately, OSTBCs exist for only certain numbers of transmit antennas and do not provide array gain as diversity techniques that exploit transmit channel information do. When channel state information is available at the transmitter, linearly precoded space-time codes can he used to support different numbers of transmit antennas and to improve array gain. Precoding generally requires complete channel knowledge, thus motivating limited feedback methods such as channel quantization or antenna subset selection. The paper investigates limited feedback precoding that uses a codebook of matrices known a priori to both the transmitter and receiver. Using the codebook, the receiver chooses a matrix based on current channel conditions and conveys the optimal codebook matrix to the transmitter over an error-free, zero-delay feedback channel A precoder matrix selection criterion is proposed that relates directly to minimizing the probability of symbol error of the precoded system. Low average distortion codebooks based on Grassmannian subspace packing are derived for the optimal codeword selection criterion. It is shown that codebooks designed by this method provide full diversity order in Rayleigh fading channels.
The Functions of Klarsicht and Nuclear Lamin in Developmentally Regulated Nuclear Migrations of Photoreceptor Cells in theDrosophilaEye (2003)

Photoreceptor nuclei in the Drosophila eye undergo developmentally regulated migrations. Nuclear migration is known to require the perinuclear protein Klarsicht, but the function of Klarsicht has been obscure. Here, we show that Klarsicht is required for connecting the microtubule organizing center (MTOC) to the nucleus. In addition, in a genetic screen for klarsicht-interacting genes, we identified Lam Dm(0), which encodes nuclear lamin. We find that, like Klarsicht, lamin is required for photoreceptor nuclear migration and for nuclear attachment to the MTOC. Moreover, perinuclear localization of Klarsicht requires lamin. We propose that nuclear migration requires linkage of the MTOC to the nucleus through an interaction between microtubules, Klarsicht, and lamin. The Klarsicht/lamin interaction provides a framework for understanding the mechanistic basis of human laminopathies.
Network Service Header (2015)

This draft describes a Network Service Header (NSH) inserted onto
encapsulated packets or frames to realize service function paths. NSH
also provides a mechanism for metadata exchange along the instantiated
service path.
“NO MATARÁS”: REFLEXIONES Y APORTES PARA UN DEBATE SOBRE LAS FORMAS DEL RECUERDO Y LAS PRÁCTICAS POLÍTICAS EN LA ARGENTINA (2007)

Este trabajo tiene como objetivo realizar una reflexión sobre diferentes aspectos abiertos por el testimonio de Héctor Jouvé, integrante del grupo guerrillero guevarista Ejército Guerrillero del Pueblo (EGP), que en una entrevista para la revista cordobesa La Intemperie relató los fusilamientos de guerrilleros guevaristas realizados por los propios compañeros del EGP a fines de la década del 60. El relato originó la posterior carta del filósofo y ex militante Oscar Del Barco que puso bajo crítica el uso de la violencia política que caracterizó a la militancia de las décadas del 60 y 70. A partir de allí se abrió una intensa polémica que transcurrió en diversas publicaciones y aún no se ha agotado. A través de un recorrido conceptual propio, el artículo intenta desarrollar un análisis sobre cuatro vertientes: los aspectos éticos y políticos que puso de relieve el debate; la representación de la militancia y la violencia política de las décadas del 60 y 70 en la izquierda nacional durante el período democrático; la particular reactualización de la “teoría de los dos demonios” que reintroduce la polémica y, por último, la cuestión de la transmisión de la historia de la militancia de generación en generación.
Electrode-Biologic Tissue Interreactions at Interfaces - A Review (1984)

This review draws attention on the accuracy and usefulness of the study of electrode phenomenon at the interfaces with an emphasis on the metals and their interreaction with surrounding cells and proteins.
Visible‐Light Photochromism of Triarylamine‐ or Ferrocene‐Bound Diethynylethenes that Switches Electronic Communication between Redox Sites and Luminescence (2008)

Redox-active ferrocene- and triarylamine-terminated diethynylethene derivatives have been synthesized and their photochromic properties and switching behavior based on through-bond electronic communication between the two redox sites, as well as their emissions, have been examined. Both bis(ferrocenylethynyl)ethene 1 and bis(triarylaminoethynyl)ethene 2 show visible-light photochromism induced by donor-acceptor charge-transfer (CT) transitions from the ferrocene or triarylamine to the diethynylethene moieties. The reversibility and quantum yields of the photochromism of 2 (Phi(E-->Z)=6.1 x 10(-2), Phi(Z-->E)=1.4 x 10(-2)) are far higher than those of 1 (Phi(E-->Z)=8.6 x 10(-6), Phi(Z-->E)=2.5 x 10(-6)). The higher efficiency in 2 may be attributed to the absence of the heavy atom effect and of a low-lying (3)LF state, which are characteristic of ferrocenyl compounds. This proposition is further supported by the fact that bis(ferrocenylbuta-1,3-diynyl)ethene 3, which, unlike 1, is free from steric interference between the two ferrocenyl groups in the Z form, does not show a significant improvement in its photoisomerization quantum yields (Phi(E-->Z)=6.2x10(-5), Phi(Z-->E)=3.4 x 10(-5)). The visible-light photochromism of 1 and 2 is accompanied by a switch in the strength of the electronic communication between the two redox sites in their mixed-valence states (DeltaE(0)' values are 70 and 48 mV for (E)-1 and (Z)-1, and 74 and 63 mV for (E)-2 and (Z)-2). In the case of 2, further evaluations were carried out through intervalence charge-transfer (IVCT) band analyses and DFT calculations. We have also demonstrated that steric repulsion between the methyl ester moieties in the Z form is implicated in the reduction in the through-bond electronic communication. Compound 2 exhibits photoluminescence, which is more efficient in the E form than in the Z form, whereas 1 and 3 show no photoluminescence.
Guidance to Design the Polymeric Dispersant (2013)

高分子分散剤の選定や設計に参考となる事例や考え方を解説した。分散剤が作用する各過程を，ぬれ・吸着・安定化に分け，それぞれで必要とされる機能を考えた。吸着・安定化には多点吸着やトレイン－ループ－テイル型吸着形態のとれる高分子量体が有利である。ぬれ促進のための表面張力低下に適したアルキル基の炭素数を前進接触角（θa）と後退接触角（θr）から推定した。分散剤水溶液の濃度と表面張力の関係からモノマー連鎖制御の有無によるミセル形成プロセスの違いをモデル化し，分散剤に適した分子構造を推定した。分散剤開発に有効なCRP技術の最近の進歩から，金属触媒使用量減と取り扱い性が向上したICAR ATRPと，付加解裂型連鎖移動反応性を示すMSD（α-メチルスチレンダイマー）由来不飽和基による合成例を紹介した。
A tecnologia da informação em instituições de preservação cultural: relato de experiência no instituto memória histórica e cultural da Universidade de Caxias do Sul (2022)

A preservação e o gerenciamento da informação é crucial para qualquer organização. O Instituto Memória Histórica e Cultural (IMHC) visa restaurar e preservar artefatos que retratam a vida dos habitantes da serra gaúcha. Considerando a importância do acervo como fonte de estudo para diversas áreas do conhecimento, constatou-se a necessidade de padronizar o sistema arquivístico pertinente ao IMHC. Este processo é relevante uma vez que alguns dos departamentos do IMHC possuem seu próprio sistema de banco de dados, enquanto outros não possuem ferramentas tecnológicas para o gerenciamento do conteúdo arquivístico. O presente artigo tem como objetivo relatar a aplicabilidade dos softwares Archivematica e AtoM junto ao acervo histórico cultural do IMHC. Os resultados indicam que os softwares proporcionarão as funcionalidades necessárias para o gerenciamento do acervo arquivístico, contribuindo para a gestão informacional do IMHC.
Bootstrapping bispectra: an application to testing for departure from Gaussianity of stationary signals (1999)

We propose a bootstrap version of a bispectrum-based test for departure from Gaussianity that achieves high power while maintaining the level of significance, even for small sample sizes. The proposed procedure can be also used to set confidence bands for a measure of the bicoherence of stationary random signals.
Enhancement of output power from narrow linewidth amplifiers via two-tone effect - high power experimental results (2010)

Two-tone 1064 nm fiber amplifiers having both cold (16°C) and pump induced temperature zones co-seeded with narrow linewidth 1064 nm and broad linewidth 1040 nm photons have been shown to have a power enhancement factor between 1.6 and 1.8 relative to the optimum single-tone 1064 nm amplifier while maintaining an efficiency of 65% or greater. The output power and efficiency of 1064 nm narrow linewidth two-tone amplifiers is dependent on the length of the gain fiber, the narrow to broad linewidth seed ratio, the wavelength of the broad linewidth seed and the temperature of the gain fiber.
Implementation of an interactive liver surgery planning system (2011)

Liver tumor, one of the most wide-spread diseases, has a very high mortality in China. To improve success rates of liver surgeries and life qualities of such patients, we implement an interactive liver surgery planning system based on contrastenhanced liver CT images. The system consists of five modules: pre-processing, segmentation, modeling, quantitative analysis and surgery simulation. The Graph Cuts method is utilized to automatically segment the liver based on an anatomical prior knowledge that liver is the biggest organ and has almost homogeneous gray value. The system supports users to build patient-specific liver segment and sub-segment models using interactive portal vein branch labeling, and to perform anatomical resection simulation. It also provides several tools to simulate atypical resection, including resection plane, sphere and curved surface. To match actual surgery resections well and simulate the process flexibly, we extend our work to develop a virtual scalpel model and simulate the scalpel movement in the hepatic tissue using multi-plane continuous resection. In addition, the quantitative analysis module makes it possible to assess the risk of a liver surgery. The preliminary results show that the system has the potential to offer an accurate 3D delineation of the liver anatomy, as well as the tumors' location in relation to vessels, and to facilitate liver resection surgeries. Furthermore, we are testing the system in a full-scale clinical trial.
Effects of airborne hydrocarbon adsorption on pool boiling heat transfer (2020)

During pool boiling, a significantly high heat flux leads to the transition from nucleate boiling to film boiling, where a vapor film forms over the boiling surface, drastically increasing thermal resistance. This transition at the critical heat flux (CHF) results in an abrupt increase in surface temperature and can lead to catastrophic failure of the boiler. However, reported CHF values vary greatly, even for smooth surfaces of the same material; for example, the CHF values on flat silicon and silicon dioxide surfaces vary across studies by up to 49% and 84%, respectively. Here, we address this discrepancy by accounting for hydrocarbon adsorption on boiling surface. Hydrocarbon adsorption on smooth boiling surfaces decreases surface wettability, hindering the ability to maintain liquid contact with the surface and, thus, lowering the pool boiling CHF. To investigate hydrocarbon adsorption kinetics under ambient conditions and the subsequent effect on CHF, we cleaned flat silicon dioxide samples with argon plasma to remove hydrocarbon contaminants and then exposed them to laboratory air for different periods of time before conducting pool boiling experiments. Pool boiling results along with x-ray photoelectron spectroscopy data showed that the amount of adsorbed hydrocarbon increased with exposure time in air, which resulted in a decrease in wettability and, accordingly, a decrease in CHF. This work has important implications for understanding the spread in CHF values reported in the literature and may serve as a guideline for the preparation of boiling surfaces to achieve consistent experimental results.
PREDICTIVE VALUE OF VON WILLEBRAND FACTOR TO RISTOCETIN COFACTOR RATIO AND THROMBIN-ANTITHROMBIN COMPLEX LEVELS FOR HEPATIC VESSEL THROMBOSIS AND GRAFT REJECTION AFTER LIVER TRANSPLANTATION (1994)

Acute cellular rejection and hepatic vessel thrombosis are significant postoperative complications of liver transplantation. The study investigated changes in endothelial cell-related hemostatic proteins in the peripheral circulation of patients after liver transplantation, and assays for hemostatic parameters were compared with data from routine hematologic and biochemical investigations, together with clinical information. Of the 12 patients, 8 underwent acute rejection episodes. No significant differences in any hemostatic parameter measured were seen between rejection and nonrejection groups, with the exception of the platelet count, which increased after treatment of the rejection episode. Two of the 12 patients suffered fatal hepatic vessel thrombosis during the study. A number of significant differences were found between these patients and those with no thrombotic complications, most notably an increase in the von Willebrand factor antigen to ristocetin cofactor ratio and thrombin-an-tithrombin complex generation. These changes occurred before clinical detection of thrombosis. Thus, measurement of these parameters may be of predictive value in the diagnosis and monitoring of post-transplant thrombosis.
The Roles of Telomerase in the Generation of Polyploidy (2013)

Polyploidy contributes to extensive intratumor genomic heterogeneity that characterizes advanced malignancies and is thought to limit the efficiency of current cancer therapies. It has been shown that telomere deprotection in p53-deficient mouse embryonic fibroblasts leads to high rates of polyploidization. We now show that tumor genome evolution through whole-genome duplication occurs in ∼15% of the karyotyped human neoplasms and correlates with disease progression. In a panel of human cancer and transformed cell lines representing the two known types of genomic instability (chromosomal and microsatellite), as well as the two known pathways of telomere maintenance in cancer (telomerase activity and alternative lengthening of telomeres), telomere dysfunction–driven polyploidization occurred independently of the mutational status of p53. Depending on the preexisting context of telomere maintenance, telomerase activity and its major components, human telomerase reverse transcriptase (hTERT) and human telomerase RNA component (hTERC), exert both reverse transcriptase–related (canonical) and noncanonical functions to affect tumor genome evolution through suppression or induction of polyploidization. These new findings provide a more complete mechanistic understanding of cancer progression that may, in the future, lead to novel therapeutic interventions.
Vaporsense Contamination-Resistant High Temperature UV Hygrometer (1988)

The use of reliable and accurate hygrometers to monitor and control the operation of drying hoods would result in significant energy savings and improvement in product quality. We have developed such a hygrometer, VaporSense, which operates at high temperature and humidity in environments containing high concentrations of particulates and corrosive vapors. VaporSense uses the differential absorption of light by water vapor wavelengths to determine absolute humidity. A UV fiber-optic prulit, is inserted into the contaminating environment. Optical surfaces are kept clean by a curtain of dry air. VaporSense prototypes have been installed in a variety of industrial drying sites. Stable, long term, contamination free operation was demonstrated.
A practical scheme for string commitment based on the Gaussian channel (2008)

We consider the problem of information-theoretically secure string commitment using a channel with additive white Gaussian noise. While the current results in the literature mainly present existence results for such schemes, we present here a practical scheme using lattice codes and analyze its security parameters for finite code lengths.
Method of predicting number of on-demand video requests using time series data for video cache system (2008)

We propose a method of predicting the number of requests for video titles in an on-demand video delivery system considering their time dependency. To handle many heterogeneous video requests in a video streaming delivery network system using video servers, it is effective to introduce video caching systems in the network system. For the cache system design in video delivery network systems, an effective cache algorithm for predicting how many requests will occur in the future is needed. Since almost all such proposed algorithms are for WWW systems, they do not consider the time dependency of the number of requests, so they are not applicable to a video system with time-dependent requests because a customer in the system watches one video title just one time. In our method, the number of requests is represented by a function of time by considering how a customer obtains information about a video and requests it and by considering that a customer requests each video only once. We have developed a method of calculating the coefficients of the function from the series of the number of requests and for estimating the number of requests in the future. We evaluated the convergence and calculation time. The results show that the calculations converge and the calculation time is 31 ms. They also show that the calculation cost is acceptable for a general video delivery system.
Routine repeat head CT may not be necessary for patients with mild TBI (2018)

Level III.
Supramolecular methods: the 8-hydroxypyrene-1,3,6-trisulfonic acid (HPTS) transport assay (2021)

The liposomal membrane transport assay, which uses 8-hydroxypyrene-1,3,6-trisulfonic acid to monitor the internal pH of the vesicles (the HPTS assay), is a widely used technique for analysing the activity of anionophore-facilitated transport across a phospholipid membrane. This paper describes the stepwise technique to conduct this transport assay, detailing both the perks and pitfalls of using this method to determine the activity of an anionophore and the transport mechanism.