gebhart/patrepeval huggingface dataset:
Spontaneous regression of multiple seborrheic keratoses associated with nasal carcinoma (2001)

Seborrheic keratoses are very common epidermal neoplasms. We describe a patient with seborrheic keratoses presenting multifocal spontaneous regression. The patient had a concurrent nasal adenoid cystic carcinoma. The simultaneous regression of seborrheic keratoses ceased after total resection of the nasal carcinoma. Histological examination revealed marked infiltration of mononuclear cells, including CD4+, CD8+, CD68+ and cutaneous lymphocyte-associated antigen-positive cells, with profound accumulation of CD1a+ dendritic cells. Although apoptotic keratinocytes were not found in the lesional epidermis by histology, the majority of keratinocytes in the regressing seborrheic keratosis were positively stained by the TUNEL method. We postulate that the internal malignancy may induce spontaneous regression of seborrheic keratoses.
Construction of Optically Active Indolines by Formal [4+1] Annulation of Sulfur Ylides and N‐(ortho‐Chloromethyl)aryl Amides (2013)

Get asymmetric! Asymmetric [4+1] annulation of sulfur ylides and N-(ortho-chloromethyl)aryl amides allowed the formation of the desired cycloadduct with moderate to high yields and enantioselectivities (see scheme). The described strategy, taking advantage of chiral sulfur ylides, represents a direct procedure to access chiral 2-substituted indolines.
Oriented Molecule Beams Via the Electrostatic Hexapole: Preparation, Characterization, and Reactive Scattering (1989)

Machine learning (ML) is transforming all areas of science. The complex and time-consuming calculations in molecular simulations are particularly suitable for an ML revolution and have already been profoundly affected by the application of existing ML ...Read More
Selenoformaldehyde phosphorescence observed in the reaction of molecular fluorine with dimethyl diselenide (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSelenoformaldehyde phosphorescence observed in the reaction of molecular fluorine with dimethyl diselenideRobert J. Glinski, Elizabeth A. Mishalanie, and John W. BirksCite this: J. Am. Chem. Soc. 1986, 108, 3, 531–532Publication Date (Print):February 1, 1986Publication History Published online1 May 2002Published inissue 1 February 1986https://pubs.acs.org/doi/10.1021/ja00263a042https://doi.org/10.1021/ja00263a042research-articleACS PublicationsRequest reuse permissionsArticle Views104Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Advanced Drilling Simulation Environment for Testing New Drilling Automation Techniques (2012)

Abstract Newly developed drilling automation systems locate a computer interface between commands issued by the driller and instructions transmitted to the drilling machinery. Such functions are capable of faster and more precise control than achieved by an unaided operator and thus can help drilling within narrow margins. To ensure that these systems work properly in all circumstances, an advanced drilling simulator has been developed to enable testing under a wide range of simulated conditions. The environment described in this paper uses hardware in the loop simulation to verify that the automation techniques being tested respond correctly in real-time. Rigorously validated physical models of the drilling process simulate the response of the well to the commands given to the drilling machines. Abnormal drilling conditions (pack-offs, kicks, etc.), and equipment or machine related problems (plugged nozzles, power shortage, etc.) are convincingly recreated. The drilling simulator models the behavior of surface equipment like the activation of gate valves to line up different pits or the flow in the mud return. It simulates changes in the drilling fluid properties when mixing additives to the mud. It is therefore possible to focus training sessions on cooperation between different groups at the wellsite. This is particularly useful when planning the introduction of drilling automation that involves new work procedures as a result of automation and adaptation of the drilling team to a new operational environment. Drilling operations are becoming more and more complex. Automation has the potential to provide large improvements in efficiency and safety, but automation technologies must be implemented correctly at the workplace. In the same way as the aviation industry has utilized simulated environments for decades, drilling simulation environments are the key to the safe and successful implementation of drilling automation and the development of crew skills to face future challenges.
Abstract 3647: Single cell RNA sequencing reveals mitogenic and progenitor gene programs inBRAF-rearranged pilocytic astrocytomas (2019)

Single-cell RNA sequencing (scRNAseq) has been performed across a range of intermediate to high-grade gliomas that each harbor multiple driver mutations. Pilocytic astrocytoma (PA), the most common childhood brain tumor, is a low-grade glioma. PAs frequently harbor oncogenic KIAA1549-BRAF fusions, and exhibit low rates of other driver mutations. While PAs exhibit a favorable prognosis compared to the higher-grade gliomas, treatment morbidity and tumor recurrence can represent major challenges for some PA patients. We performed scRNAseq of both tumor and non-tumor cells in newly-diagnosed PAs that contained KIAA1549-BRAF rearrangements. To confidently distinguish tumor cells from nontumor cells, we sorted cells by glial progenitor marker A2B5 status and profiled KIAA1549-BRAF fusion status of cells using a sensitive quantitative PCR-based assay. Results were validated using RNA in situ hybridization. When compared to higher-grade gliomas, a higher proportion of the PA tumor cells exhibited a differentiated, astrocyte-like phenotype. A smaller proportion of cells exhibited a progenitor-like phenotype with evidence of proliferation. These progenitor-like tumor cells expressed a mitogen-activated protein kinase (MAPK) program that was absent from higher-grade gliomas. Similar patterns of expression of genes associated with the astrocyte-like and MAPK gene programs were also seen in formalin fixed, paraffin embedded PA tissues using RNA in situ hybridization. Immune cells, especially microglia, comprised almost half of all cells in the PAs and accounted for differences in bulk expression profiles between tumor locations and subtypes. These single cell transcriptional data reveal a transcriptional developmental hierarchy in a pediatric low grade glioma that is skewed towards more mature brain cells compared to higher-grade gliomas. The results indicate that future analyses of bulk PA tissues should attempt to account for considerable infiltration by nontumor cells. Finally, the finding that a MAPK gene program is not uniformly expressed in PA tumor cells has implications for ongoing clinical investigations of therapies directed at the MAPK pathway for the treatment of PA.Citation Format: Zachary J. Reitman, Brenton Paolella, Guillaume Bergthold, Kristine Pelton, Robert Jones, Sarah Becker, Claire E. Sinai, Haley Malkin, Ying Huang, Leslie Grimmett, Zachary T. Herbert, Yu Sun, Jessica Weatherbee, John Alberta, John Daley, Orit Rozenblatt-Rosen, Rosalind Segal, Daphne Haas-Kogan, Mariella G. Filbin, Mario L. Suva, Aviv Regev, Charles Stiles, Mark W. Kieran, Liliana Goumnerova, Keith L. Ligon, Alex K. Shalek, Pratiti Bandopadhayay, Rameen Beroukhim. Single cell RNA sequencing reveals mitogenic and progenitor gene programs inBRAF-rearranged pilocytic astrocytomas [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3647.
Optimized provisioning of SDN-enabled virtual networks in geo-distributed cloud computing datacenters (2017)

Cloud computing provides on-demand IT services via large distributed datacenters over high-speed networks. Virtualization, a key cloud computing technology, allows service providers to offer computing services in cloud environments without platform compatibility discrepancies. The recent proliferation of cloud computing has rekindled interest in network virtualization. Thus, network virtualization is emerging as a polymorphic approach for the future Internet that will facilitate the use of shared resources. Virtual network provisioning is considered to be a main resource allocation challenge in any virtualized network environment. Software-defined networking (SDN) imparts flexibility to a network by removing the control layer from the data transfer layer of the network and moving it to the control plane. Network virtualization is further employed to share physical infrastructure to enable multiple service providers to access the network. Flexible access requires efficient management of network resources; the SDN control plane can be used for efficient management of virtual networks. In this study, we formulate virtual network provisioning in SDN-enabled, geographically distributed cloud computing datacenters as a mixed integer linear programming (MILP) problem. The formulation of the proposed optimized virtual network provisioning (OVNP) model is studied by means of simulations. The performance of the proposed approach is measured against enhanced network cloud provisioning (ENCP), our previous research, and other recognized research focused on the ratio of successfully provisioned requests and the efficiency of resource utilization The results verify the effectiveness of the proposed approach.
Structure and Absolute Configuration of Pseudohygrophorones A12 and B12, Alkyl Cyclohexenone Derivatives from Hygrophorus abieticola (Basidiomycetes) (2015)

Pseudohygrophorones A(12) (1) and B(12) (2), the first naturally occurring alkyl cyclohexenones from a fungal source, and the recently reported hygrophorone B(12) (3) have been isolated from fruiting bodies of the basidiomycete Hygrophorus abieticola Krieglst. ex Gröger & Bresinsky. Their structures were assigned on the basis of extensive one- and two-dimensional NMR spectroscopic analysis as well as ESI-HRMS measurements. The absolute configuration of the three stereogenic centers in the diastereomeric compounds 1 and 2 was established with the aid of (3)JH,H and (4)JH,H coupling constants, NOE interactions, and conformational analysis in conjunction with quantum chemical CD calculations. It was concluded that pseudohygrophorone A(12) (1) is 4S,5S,6S configured, while pseudohygrophorone B(12) (2) was identified as the C-6 epimer of 1, corresponding to the absolute configuration 4S,5S,6R. In addition, the mass spectrometric fragmentation behavior of 1-3 obtained by the higher energy collisional dissociation method allows a clear distinction between the pseudohygrophorones (1 and 2) and hygrophorone B(12) (3). The isolated compounds 1-3 exhibited pronounced activity against phytopathogenic organisms.
Wireless Fetal Heart Rate Monitoring in Inpatient Full-Term Pregnant Women: Testing Functionality and Acceptability (2015)

We tested functionality and acceptability of a wireless fetal monitoring prototype technology in pregnant women in an inpatient labor unit in the United States. Women with full-term singleton pregnancies and no evidence of active labor were asked to wear the prototype technology for 30 minutes. We assessed functionality by evaluating the ability to successfully monitor the fetal heartbeat for 30 minutes, transmit this data to Cloud storage and view the data on a web portal. Three obstetricians also rated fetal cardiotocographs on ease of readability. We assessed acceptability by administering closed and open-ended questions on perceived utility and likeability to pregnant women and clinicians interacting with the prototype technology. Thirty-two women were enrolled, 28 of whom (87.5%) successfully completed 30 minutes of fetal monitoring including transmission of cardiotocographs to the web portal. Four sessions though completed, were not successfully uploaded to the Cloud storage. Six non-study clinicians interacted with the prototype technology. The primary technical problem observed was a delay in data transmission between the prototype and the web portal, which ranged from 2 to 209 minutes. Delays were ascribed to Wi-Fi connectivity problems. Recorded cardiotocographs received a mean score of 4.2/5 (± 1.0) on ease of readability with an interclass correlation of 0.81(95%CI 0.45, 0.96). Both pregnant women and clinicians found the prototype technology likable (81.3% and 66.7% respectively), useful (96.9% and 66.7% respectively), and would either use it again or recommend its use to another pregnant woman (77.4% and 66.7% respectively). In this pilot study we found that this wireless fetal monitoring prototype technology has potential for use in a United States inpatient setting but would benefit from some technology changes. We found it to be acceptable to both pregnant women and clinicians. Further research is needed to assess feasibility of using this technology in busy inpatient settings.
Combining an amyloid‐beta (Aβ) cleaving enzyme inhibitor with a γ‐secretase modulator results in an additive reduction of Aβ production (2014)

A major hallmark of Alzheimer's disease (AD) is the deposition of amyloid-β (Aβ) peptides in amyloid plaques. Aβ peptides are produced by sequential cleavage of the amyloid precursor protein by the β amyloid cleaving enzyme (BACE) and the γ-secretase (γ-sec) complex. Pharmacological treatments that decrease brain levels of in particular the toxic Aβ42 peptide are thought to be promising approaches for AD disease modification. Potent and selective BACE1 inhibitors as well as γ-sec modulators (GSMs) have been designed. Pharmacological intervention of secretase function is not without risks of either on- or off-target adverse effects. One way of improving the therapeutic window could be to combine treatment on multiple targets, using smaller individual doses and thereby minimizing adverse effect liability. We show that combined treatment of primary cortical neurons with a BACE1 inhibitor and a GSM gives an additive effect on Aβ42 level change compared with the individual treatments. We extend this finding to C57BL/6 mice, where the combined treatment results in reduction of brain Aβ42 levels reflecting the sum of the individual treatment efficacies. These results show that pharmacological targeting of two amyloid precursor protein processing steps is feasible without negatively interfering with the mechanism of action on individual targets. We conclude that targeting Aβ production by combining a BACE inhibitor and a GSM could be a viable approach for therapeutic intervention in AD modification.
The Role of P-Glycoprotein in the Pharmacokinetics and Tissue Distribution of a Hepatitis C Virus Protease Inhibitor (2009)

S5, a hepatitis C virus protease inhibitor, displays partially saturable efflux in the Caco-2 system. In addition, the efflux can be reversed by cyclosporine, indicating that S5 may be a human P-glycoprotein (P-gp) substrate. S5 can also activate the ATPase activity in vesicle membranes containing mouse P-gp 1a and 1b, suggesting that S5 may be a substrate for mouse P-gp. The pharmacokinetics and tissue distribution of S5 were evaluated after intravenous and oral administration to wild-type and 1a/1b knockout mice. Plasma and kidney levels of this compound in knockout mice were transiently higher than those in wild-type mice only after oral dosing, indicating effective P-gp efflux occurs in wild-type mice. The levels of S5 in brain samples from knockout mice were higher than those from wild-type mice after both intravenous and oral administration, but much more significantly after intravenous administration. The levels in liver were four time higher in knockout mice than in wild-type mice after oral administration, but were not different between knockout and wild-type mice after intravenous administration. These results suggest that P-gp efflux limits exposure to S5 in the brain and liver, and that the effect is dependent on the route of administration.
Homocystinuria due to cystathionine β‐synthase deficiency: Novel biochemical findings and treatment efficacy (2003)

To explore the pathogenesis of cystathionine beta-synthase (CBS) deficiency and to test the efficacy of pharmacological therapy we examined a panel of metabolites in nine homocystinuric patients under treated and/or untreated conditions. Off pharmacological treatment, the biochemical phenotype was characterized by accumulation of plasma total homocysteine (median 135 micromol/L) and blood S -adenosylhomocysteine (median 246 nmol/L), and by normal levels of guanidinoacetate and creatine. In addition, enhanced remethylation was demonstrated by low serine level (median 81 micromol/L), and by increased concentration of methionine (median 76 micromol/L) and N -methylglycine (median 6.8 micromol/L). Despite the substantially blocked transsulphuration, which was evidenced by undetectable cystathionine and severely decreased total cysteine levels (median 102 micromol/L), blood glutathione was surprisingly not depleted (median 1155 micromol/L). In 5 patients in whom pharmacological treatment was withdrawn, the differences of median plasma total homocysteine levels (125 micromol/L after withdrawal versus 33 micromol/L under treatment conditions), total cysteine levels (139 versus 211 micromol/L) and plasma serine levels (53 versus 103 micromol/L) on and off treatment demonstrated the efficacy of long-term pyridoxine/betaine administration ( p <0.05). The treatment also decreased blood S -adenosylhomocysteine level (133 versus 59 nmol/L) with a borderline significance. In summary,our study shows that conventional treatment of CBS deficiency by diet and pyridoxine/betaine normalizes many but not all metabolic abnormalities associated with CBS deficiency. We propose that the finding of low plasma serine concentration in untreated CBS-deficient patients merits further exploration since supplementation with serine might be a novel and safe component of treatment of homocystinuria.
Evaluation of Butylated Hydroxytoluene as a Cryopreservative Added to Whole or Skim Milk Diluent for Bull Semen (1989)

Effect of five concentrations of butylated hydroxytoluene on the percent motility and percent intact acrosomes was evaluated for bull sperm frozen and thawed in whole and skim milk diluents. Twelve ejaculates were frozen in .5-ml straws in moving nitrogen vapor after each ejaculate was split among the five butylated hydroxytoluene treatments within the two diluents. Prefreeze and postthaw percent motility and postthaw percent intact acrosomes were evaluated at 0 and 4 h. Before freezing, sperm motilities were similar in whole or skim milk diluents with and without butylated hydroxytoluene. Upon thawing, sperm motility was 10 percentage points higher in whole milk diluent containing .5 and .75 mM butylated hydroxytoluene than in samples without it. After 4 h, percentage motile sperm was similar among all whole milk treatments. Sperm motility was similar among all skim milk treatments at both 0 and 4 h. Percent intact acrosomes were similar among all treatments for each diluent. Oxidation in whole milk diluent stored at 4 degrees C for 1 wk was reduced in the presence of 1.0, 2.0, and 4.0 mM butylated hydroxytoluene.
Application of Ionic Liquids in Separation and Downstream Processing of Biomolecules (2015)

Use of conventional organic solvents in an extraction brings problems such as toxicity, volatility, flammability and denaturization of biomolecules. In contrast, Ionic liquids, which are called as green solvents, are composed completely of ions and devoid of these problems. Traditional organic solvents have been replaced by Ionic liquids in many industrial applications such as organic synthesis, catalysis, extraction (liquid phase micro-extraction, solid phase micro-extraction and liquid-liquid extraction), adsorption, chromatography (mobile phase additives) and supported liquid membranes. Even though, the applications of ionic liquids in bioseparations are in their early stages, the academic interest in ionic liquids is in the rise. The major applications of ionic liquids in separation technology are presented in this present review paper. Furthermore, the future scenario of the ionic liquids in separation techniques is discussed. Keywords: Ionic liquids, downstream processing, separation, liquid-liquid extraction, supported membranes, extraction.
Decentralized Gathering of Stochastic, Oblivious Agents on a Grid: A Case Study with 3D M-Blocks (2019)

We propose stochastic control policies for gathering a group of embodied agents in a two-dimensional square tile environment. The policies are fully decentralized and can be executed on anonymous, oblivious agents with chirality, but no sense of orientation. The agents require only 4 ternary digits of information. We prove that a group of agents, irrespective of initial positions, will almost surely reach a Pareto optimal configuration in finite time. For one of the control policies, computer simulations show that groups of up to 20 agents consistently reach Pareto optimal configurations, whereas groups of 1000 agents, given the same amount of time, improve the compactness of their configurations on average by 89.20%. The policy also copes well with sensory noise up to a level of 50%. We also present an experimental validation using 6 physical 3D M-Block modules, demonstrating the feasibility of the stochastic control approach in practice.
Narrow-linewidth mid-infrared coherent sources based on fiber-amplified Er:ZBLAN microspherical lasers (2016)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text B. Behzadi, R. K. Jain, and M. Hossein-Zadeh, "Narrow-linewidth mid-infrared coherent sources based on fiber-amplified Er:ZBLAN microspherical lasers," in Conference on Lasers and Electro-Optics, OSA Technical Digest (2016) (Optica Publishing Group, 2016), paper STh1O.5. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Effects of ascorbic acid and DL-alpha-tocopherol on human hepatoma cell proliferation and redifferentiation. (2000)

AA and alpha T combination inhibited human hepatoma cell proliferation, induced redifferentiation, and reversed its malignant phenotypic characteristics.
2‐(Tributylstannyl)‐1‐{[2‐(trimethylsilyl)ethoxy]methyl}‐1H‐indole: Synthesis and use as a 1H‐indol‐2‐yl‐anion equivalent (1993)

Abstract Pd‐Catalyzed reaction of 2‐(tributylstannyl)‐1‐{[2‐(trimethylsilyl)ethoxy]methyl}‐1 H ‐indole ( 5 ) with a variety of aryl, heteroaryl, vinyl, and allyl halides provides an efficient entry to the corresponding cross‐coupled products (see Table ).