gebhart/patrepeval huggingface dataset:
Cognate interactions between mast cells and helper T lymphocytes (2010)

Mast cells are key effectors in allergy and inflammation. Endowed with a large panel of surface receptors and a huge arsenal of bioactive mediators, they readily communicate with various cellular partners during innate and adaptive immune responses. Recent lines of evidence show that mast cells are also able to establish cognate interactions with helper T lymphocytes for antigen presentation and bidirectional cell-cell cooperation. In this short review we focus on the role of mast cells as unconventional antigen presenting cells for helper T lymphocytes. We discuss how looking at mast cell biology from this new angle can help to better understand their pleiotropic role in health and disease.
MIMOSA, une modélisation de l'économie mondiale (1990)

MIMOSA, modèle macroéconomique de l'économie mondiale, construit en commun par le CEPII et l'OFCE est maintenant opérationnel. Le présent article en présente les principales caractéristiques ainsi que quelques propriétés variantielles. Les économies des six plus importants pays industrialisés sont décrites en détail par des modèles d'inspiration néo-keynésienne ; le découpage en cinq branches permet d'isoler l'énergie, le secteur agricole, le secteur abrité, le secteur non-marchand et l'industrie où la fonction de production, de type putty-clay, permet d'assurer la cohérence des comportements d'emploi, d'investissement, d'accumulation de capacités de production. Ces modèles autorisent une analyse fine des diverses mesures de politiques budgétaires ou monétaires. Neufs zones, analysées plus sommairement, regroupent le reste du monde : le modèle intègre en particulier les contraintes de financement qui pèsent sur les possibilités d'importations des pays en développement. Les interdépendances commerciales sont décrites en quatre produits. L'article analyse comment le modèle rend compte des effets différenciés sur l'économie considérée et sur l'économie mondiale d'une hausse des dépenses publiques survenant dans un des grands pays. Il étudie ensuite les conséquences d'une baisse du dollar, puis d'une baisse généralisée des taux d'intérêt. Bien qu'il reste, à certains égards, en construction, le modèle MIMOSA constitue déjà un outil utile pour comprendre le fonctionnement de l'économie mondiale et prévoir son évolution.
Supplemental Material, Combined_supplemental_materials-Haran_et_al - Generation and Validation of an Antibody to Canine CD19 for Diagnostic and Future Therapeutic Purposes (2020)

Supplemental Material, Combined_supplemental_materials-Haran_et_al for Generation and Validation of an Antibody to Canine CD19 for Diagnostic and Future Therapeutic Purposes by Kumudhini Preethi Haran, Alexandra Lockhart, Ailian Xiong, Enrico Radaelli, Patrick J. Savickas, Avery Posey and Nicola J. Mason in Veterinary Pathology
An assessment of the mechanism of initial electron transfer in bacterial reaction centers (1991)

Subpicosecond time-resolved photodichroism measurements on Rhodobacter sphaeroides R26 reaction centers are reported in the key region between 620 and 740 nm, where the anions of both bacteriopheophytin and bacteriochlorophyll (BChl) have their most diagnostic absorption bands. These measurements fail to resolve clearly the formation of a reduced BChl species. The implications of this for elucidating the role of the accessory BChl in the initial stage of charge separation are discussed.
Development of an Improved High Cycle Fatigue Criterion (2004)

An integrated computational-experimental approach for prediction of total fatigue life applied to a uniaxial stress state is developed. The approach consists of the following elements: (1) development of a vibration based fatigue testing procedure to achieve low cost bending fatigue experiments and (2) development of a life prediction and estimation implementation scheme for calculating effective fatigue cycles. A series of fully reversed bending fatigue tests were carried out using a vibration-based testing procedure to investigate the effects of bending stress on fatigue limit. The results indicate that the fatigue limit for 6061-T6 aluminum is approximately 20% higher than the respective limit in fully reversed tension-compression (axial). To validate the experimental observations and further evaluate the possibility of prediction of fatigue life, an improved high cycle fatigue criterion has been developed, which allows one to systematically determine the fatigue life based on the amount of energy loss per fatigue cycle. A comparison between the prediction and the experimental results was conducted and shows that the criterion is capable of providing accurate fatigue life prediction.
Hybrid Processes: Design Method for Optimal Coupling of Chromatography and Crystallization Units (2003)

A general design method for the hybrid process of a chromatographic and a crystallization unit was developed. The fundamentals for the separate design of chromatographic and crystallization separation processes, as well as modeling approaches for these units, are presented. Four different test systems were chosen to show the applicability of the developed method. A focus was set on the enantioseparation of racemic compounds occurring in the pharmaceutical industry. The development of the flowsheet for the hybrid process shows that a chromatographic unit with a subsequent crystallization and recycle of the crystallizer's mother liquor to the feed of the chromatographic unit is most suitable. The possibilities of racemization and a solvent change are discussed. The influence of important operation parameters are investigated. The results for the test systems show that a hybrid process, in which both units serve as a separation process, is only suitable if the productivity of the chromatographic unit decreases sharply with increasing demands concerning the outlet purity and if the eutectic point of the racemic compound is close to 0.5.
NON ANTIHYPERTENSIVE DOSES OF PERINDOPRIL AFFORD RENOPROTECTION IN LYON GENETICALLY HYPERTENSIVE RAT (2004)

1Faculte de pharmacie - Lyon; service d'anatomopathologie – Hôpital Debrousse – Lyon and 2INSERM U367, Paris, France
Angiotensin converting enzyme: an in vivo and in vitro marker of endothelial injury. (1992)

An elevated level of von Willebrand factor (vWf) is a well-established marker for both in vivo and in vitro endothelial cell injury. Recent studies indicate that the plasma level of angiotensin-converting enzyme (ACE) in systemic sclerosis is reduced in association with elevated vWf levels. Because the endothelial cell is capable of producing both mediators, and because endothelial cell injury is a fundamental process in systemic sclerosis, we investigated in this study the effect of in vitro endothelial cell injury on the synthesis of both factors. Endothelial cells derived from human umbilical veins, in the second passage, were activated by exposure to interleukin-1 or lymphotoxin or were injured by radiation, actinomycin, or trypsin (each can be shown to induce dose-dependent endothelial cell cytotoxicity). ACE (spectrophotometric method) and vWf levels (enzyme-linked immunosorbent assay method) were determined in the supernatant and in the cell lysate 48 hours after cellular injury and activation. An increase in vWf levels was found in the lysate and in the supernatant from the cells that underwent injury or activation, whereas ACE levels were increased after activation but decreased after injury. Next, and as an in vivo clinical corollary to the in vitro endothelial cell injury, we evaluated ACE and vWf levels in the plasma of seven children in the acute phase of Kawasaki disease, a disorder characterized by widespread vascular injury. Plasma ACE levels were significantly lower than control levels, whereas vWf levels were increased, reflecting the known prominent endothelial cell injury in this disease.(ABSTRACT TRUNCATED AT 250 WORDS)
Dielectric properties of semiconducting YBaCuO thin films for future uncooled THz bolometers: characterization using a coaxial-discontinuity technique. (2011)

LGEP 2011 ID = 827
Carbon Fiber Composite - A High Capacity Anode for Lithium-ion Batteries (2007)

Abstract not Available.
Model Checking Control Communication of a FACTS Device (2006)

This paper concerns the design and verification of a realtime communication protocol for sensor data collection and processing between an embedded computer and a DSP. In such systems, a certain amount of data loss without recovery may be tolerated. The key issue is to define and verify the correctness in the presence of these lost data frames under real-time constraints. This paper describes a temporal verification that if the end processes do not detect that too many frames are lost, defined by comparison of error counters against given threshold values, then there will be a bounded delay between transmission of data frames and reception of control frames. This verification and others presented herein were performed with the model checkers SPIN and RT-SPIN
High-Speed Dynamic Programmable Logic Array Chip (1975)

This paper describes the circuit design of a programmable logic array chip using four-phase dynamic circuits, operating at a nominal cycle time of 230 nanoseconds. Bootstrap circuit techniques are used to obtain high function and performance by satisfying some special requirements of PLA designs. These include a simple means for two-bit partitioning of the data inputs, a noninverting buffer circuit between precharged arrays, and a fast, compact on-chip driver for heavily loaded arrays. Multiphase clocking enables the use of master/slave type JK flip-flops with minimum circuitry and power dissipation. A polarity hold function is provided at the outputs to allow interfacing the dynamic design to static output circuits.
Murine and Non-Human Primate Dendritic Cell Targeting Nanoparticles for in Vivo Generation of Regulatory T-Cells (2018)

Porous silicon nanoparticles (pSiNP), modified to target dendritic cells (DC), provide an alternate strategy for the delivery of immunosuppressive drugs. Here, we aimed to develop a DC-targeting pSiNP displaying c-type lectin, dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN), and CD11c monoclonal antibodies. The in vivo tracking of these fluorescent DC-targeting nanoparticles was assessed in both C57BL/6 mice and common marmosets ( Callithrix jacchus) by intravenous injection (20 mg/kg). Rapamycin and ovalbumin (OVA)<sub>323-339</sub> peptide loaded pSiNP were employed to evaluate their ability to generate murine CD4<sup>+</sup>CD25<sup>+</sup>FoxP3<sup>+</sup> regulatory T-cells in vivo within OVA sensitized mice. In vivo, pSiNP migrated to the liver, kidneys, lungs, and spleen in both mice and marmosets. Flow cytometry confirmed pSiNP uptake by splenic and peripheral blood DC when functionalized with targeting antibodies. C57BL/6 OVA sensitized mice injected with CD11c-pSiNP loaded with rapamycin + OVA<sub>323-339</sub> produced a 5-fold higher number of splenic regulatory T-cells compared to control mice, at 40 days post-pSiNP injection. These results demonstrate the importance of the immobilized targeting antibodies to enhance cellular uptake and enable the in vivo generation of splenic regulatory T-cells.
Relationship Between Mixed Chimerism and Acceptance of HLA-matched and -Mismatched Kidney Transplants after Withdrawal of Immunosuppressive Drugs (2018)

Classical studies in cattle and rodents showed that mixed chimerism established in fetuses and neonates was permanent, and was linked to immune tolerance and the acceptance of organ grafts from the hematopoietic cell donors without need for immunosuppressive (IS) drugs. The goal of the current clinical study was to determine whether establishment of persistent mixed chimerism for at least 1 year in HLA-matched and -mismatched recipients of combined kidney and hematopoietic cell transplants from living donors followed the preclinical paradigm and allowed for permanent chimerism and acceptance of transplant kidneys in the absence of IS drugs. Recipients were given a 10-day post-transplant conditioning regimen of total lymphoid irradiation and rabbit anti-thymocyte globulin. Of 29 HLA-matched patients, 24 developed mixed chimerism for at least 1 yr and were completely withdrawn from IS drugs from mo 6 through 18. There was no subsequent rejection in 23 of the 24, with up to 12 yrs of follow-up. Mixed chimerism persisted after drug withdrawal in 10, as in the preclinical studies. However, 14 had a pattern that differed from the paradigm and accepted the organ grafts after drug withdrawal despite loss of chimerism during the 2nd yr. Pts with long-term graft acceptance off drug had specific unresponsiveness to donor allo-antigens in the MLR even in the absence of stable mixed chimerism. There were 2 graft losses among the 29 during the 12-yr observation period due to return of underlying kidney disease. Biopsies obtained from mixed chimeric pts just before discontinuation of IS drugs showed no rejection. Of 22 HLA haplotype-mismatched patients, 18 have been followed for more than 1 yr, and 9 developed mixed chimerism that persisted at least 1 yr. MMF was withdrawn from the chimeric pts such that they were maintained on tacrolimus (TAC) monotherapy at the end of the 1st yr, and biopsies showed no rejection at this time. However, withdrawal of TAC in 6 during the 2nd yr resulted in loss of mixed chimerism with evidence of mild rejection in 3; they returned to IS drugs. Mixed chimerism in these HLA-mismatched pts did not follow the “classical” paradigm - it was unstable and dependent on IS drugs. The remaining persistent chimeras have been maintained on TAC monotherapy. There has been no graft loss or chronic rejection in the 22 pts, with up to 7 yrs of follow-up. Neither severe or chronic infection, nor graft versus host disease, has been observed in the HLA-matched and -mismatched pts. In conclusion, persistent mixed chimerism protected against rejection in both HLA-matched and -mismatched patients. Whereas long-term acceptance of kidney transplants off IS drugs was observed even after loss of chimerism in HLA-matched pts, protection against rejection was associated with persistence of mixed chimerism in HLA-mismatched pts. The latter outcome in HLA-mismatched pts is desirable if chimerism can be maintained on low-dose TAC monotherapy.
3D cinema to 3DTV content adaptation (2012)

3D cinema and 3DTV have grown in popularity in recent years. Filmmakers have a significant opportunity in front of them given the recent success of 3D films. In this paper we investigate whether this opportunity could be extended to the home in a meaningful way. "3D" perceived from viewing stereoscopic content depends on the viewing geometry. This implies that the stereoscopic-3D content should be captured for a specific viewing geometry in order to provide a satisfactory 3D experience. However, although it would be possible, it is clearly not viable, to produce and transmit multiple streams of the same content for different screen sizes. In this study to solve the above problem, we analyze the performance of six different disparity-based transformation techniques, which could be used for cinema-to-3DTV content conversion. Subjective tests are performed to evaluate the effectiveness of the algorithms in terms of depth effect, visual comfort and overall 3D quality. The resultant 3DTV experience is also compared to that of cinema. We show that by applying the proper transformation technique on the content originally captured for cinema, it is possible to enhance the 3DTV experience. The selection of the appropriate transformation is highly dependent on the content characteristics.
Mechanism of ATP-Dependent Promoter Melting by Transcription Factor IIH (2000)

We show that transcription factor IIH ERCC3 subunit, the DNA helicase responsible for adenosine triphosphate (ATP)-dependent promoter melting during transcription initiation, does not interact with the promoter region that undergoes melting but instead interacts with DNA downstream of this region. We show further that promoter melting does not change protein-DNA interactions upstream of the region that undergoes melting but does change interactions within and downstream of this region. Our results rule out the proposal that IIH functions in promoter melting through a conventional DNA-helicase mechanism. We propose that IIH functions as a molecular wrench: rotating downstream DNA relative to fixed upstream protein-DNA interactions, thereby generating torque on, and melting, the intervening DNA.
Structure, Crystallographic Sites, and Tunable Luminescence Properties of Eu2+ and Ce3+/Li+-Activated Ca1.65Sr0.35SiO4 Phosphors (2015)

Eu(2+) and Ce(3+)/Li(+) singly doped and Eu(2+)/Ce(3+)/Li(+)-codoped Ca1.65Sr0.35SiO4 phosphors have been synthesized by a solid-state reaction method. The crystal structure was determined by Rietveld refinement to verify the formation of the αL′-Ca2SiO4 phase with the Sr addition into Ca2SiO4, and the preferred crystallographic positions of the Eu(2+) and Ce(3+)/Li(+) ions in Ca1.65Sr0.35SiO4 were analyzed based on a comparison of the unit-cell volumes and the designed chemical compositions of undoped isostructural compounds Ca(2–x)Sr(x)SiO4 (x = 0.25, 0.35, 0.45, 0.55 and 0.65). Ce(3+)/Li(+) singly activated Ca1.65Sr0.35SiO4 phosphors exhibit strong absorption in the range of 250–450 nm and a blue emission peak centered at about 465 nm. When Eu(2+) ions are codoped, the emission colors of Ca1.65Sr0.35SiO4:Ce(3+)/Li(+),Eu(2+) phosphors under the irradiation of 365 nm can be finely tuned from blue to green through the energy transfer from Ce(3+) to Eu(2+). The involved energy-transfer process between Ce(3+) and Eu(2+) and the corresponding mechanism are discussed in detail. The reported Ca1.65Sr0.35SiO4:Ce(3+)/Li(+),Eu(2+) phosphor might be a candidate for color-tunable blue-green components in the fabrication of near-ultraviolet-pumped white-light-emitting diodes (WLEDs).
A Systematic Review on Extracellular Vesicles-Enriched Fat Grafting: A Shifting Paradigm (2020)

Abstract Background Recent evidence confirms that mesenchymal stem cells (MSCs) facilitate angiogenesis mainly through paracrine function. Extracellular vesicles (EVs) are regarded as key components of the cell secretome, possessing functional properties of their source cells. Subsequently, MSC-EVs have emerged as a novel cell-free approach to improve fat graft retention rate. Objectives The authors sought to provide a systematic review of all studies reporting the utilization of MSC-EVs to improve graft retention rate. Methods A systematic search was undertaken employing the Embase, PubMed, and Cochrane Central Register of Controlled Trials databases. Outcome measures included donor/receptor organism of the fat graft, study model, intervention groups, evaluation intervals, EV research data, and in vitro and in vivo results. Results Of the total 1717 articles, 62 full texts were screened. Seven studies reporting on 294 mice were included. Overall, EV-treated groups showed higher graft retention rates compared with untreated groups. Notably, retention rate was similar following EV and MSC treatment. In addition to reduced inflammation, graft enrichment with EVs resulted in early revascularization and better graft integrity. Interestingly, hypoxic preconditioning of MSCs improved their beneficial paracrine effects and led to a more proangiogenic EV population, as observed by both in vitro and in vivo results. Conclusions MSC-EVs appear to offer an interesting cell-free alternative to improve fat graft survival. Although their clinical relevance remains to be determined, it is clear that not the cells but rather their secretome is essential for graft survival. Thus, a paradigm shift from cell-assisted lipotransfer towards “secretome-assisted lipotransfer” is well on its way. Level of Evidence: 4
THE FORMATION OF BRAZILIAN MINERALS DATABASE FOR INTEGRATED SEM-EDS SYSTEM APPLIED TO THE GOLD ORE CHARACTERIZATION (2018)

The mineralogical characterization of the various Brazilian occurrence of minerals is presented as one of the key steps in the design of the minerals processing route and improving the overall efficiency of the process. Such information is essential in assessing the technical and economic viability of a mineral Project. Among the various mineralogical characterization techniques, automated analyzers are gaining great prominence because they provide qualitative and quantitative data in an automated manner, with great speed and accuracy. The system, available in NanoLab, laboratory of the Mining-Metallurgic Centre REDEMAT, specifically called TIMA-MIRA, is composed of a scan control program and analysis of mineral data (TIMA - Tescan Integrated Mineral Analyzer) and a scanning electron microscope with cannon field emission of electrons associated with two energy dispersive detector characteristic X-rays (MIRA - trade name). The system uses a mineral database in its operations, consisting in the association of images by back scattered electrons of the mineral grains, with their characteristic X-ray spectra and their comparison with the characteristic spectra of a database. The equipment has an interface that allows you to add minerals and other materials to their underlying database, which is critical to the accuracy of the results because the original equipment database, created, only with data of mineral samples from other countries, does not identify minerals of national origin, with its characteristic major and minor elements. These limitations of the database integrated mineral analyzer TIMA-MIRA motivated the construction of a new database through a selection methodology, preparation and analysis by diffraction rays and the TIMA-MIRA system, different context samples Brazilian geological. With the XR diffraction analysis, each mineral was determined to be analyzed in the integrated mineral analysis system. With this, we obtained the maximum and minimum values of the intensities of chemical elements peaks that make up the analyzed mineral, obtaining thus new identification rules for each selected species and adapted some existing rules, to meet the needs presented
An Adaptive Linear-Neuron-Based Third-Order PLL to Improve the Accuracy of Absolute Magnetic Encoders (2018)

Absolute magnetic encoders (AMEs) use two magnets: a ring multipolar magnet (MPM) generating high-resolution and improving the accuracy for the encoder, and a bipolar magnet in the center calculating the number cycle of MPM signals. The phase outputs of these AMEs are tracked from the sinusoidal signals of the MPM. However, these sine/cosine signals are disturbed by amplitude differences, offsets, phase-shift, harmonic components, and random noise. In order to solve this problem, this paper presents an adaptive linear neuron based on a third-order phase-locked loop (ALN-PLL) to improve the accuracy of AMEs. The proposed approach consists of two main parts: The first part is an ALN algorithm that uses the phase feedback of the third-order PLL in order to build the mathematical model of input signals, and then reject the disturbances. The second part is a third-order PLL that is designed based on a dominant pole approximation algorithm. The proposed PLL can reduce noise and eliminate dc-error during the phase step, frequency step, and frequency ramp. The simulation and experimental results demonstrate the effectiveness of the proposed approach.
Selenium heterocycles. XXXVII . Synthesis of 4‐(thiazol‐4‐yl)‐1,2,3‐selenadiazoles and 4‐(selenazol‐4‐yl)‐1,2,3‐selenadiazoles (1986)

Abstract Starting from readily available 2‐substituted‐4‐formylthiazoles and selenazoles, a series of 4‐(2‐aryl‐4‐selenazolyl)‐1,2,3‐selenadiazoles I and 4‐(2‐substituted‐4‐thiazolyl)‐1,2,3‐selenadiazoles II were prepared. Pyrolysis of compound II afforded (2‐substituted‐4‐thiazolyl) acetylenes VII. Addition of potassium hydroxide pellets to an alcoholic solution of II gave 2‐substituted‐1,4‐diselenafulvenes VIII. Decomposition of compound II with base followed by the addition of carbon disulfide gave 5‐substituted 2‐thioxo‐1,3‐thiaselenoles XI.