gebhart/patrepeval huggingface dataset:
ACNP Task Force Report on SSRIs and Suicidal Behavior in Youth (2005)

This Task Force report by the American College of Neuropsychopharmacology evaluates the safety and efficacy of selective serotonin reuptake inhibitor (SSRIs) antidepressants for depressed youth under 18 years. The report was undertaken after regulatory agencies in the United States and United Kingdom raised concerns in 2003 about the possibility that treatment of depression in children and adolescents with SSRIs may increase the risk of suicidal thinking or suicide attempts.
Setbacks in the Emergency Braking for a Crisis (2006)

The relaxation of state direct control on the economy after 1984 stimulated China's economic development greatly. In 1988, China had an "extraordinary development speed, oversized investment and a too fast-growing consumption fund." The industrial gross output value above township level grew at a rate of 17.7 percent. The total social investment in fixed assets increased from 379.2 billion yuan in 1987 to 475.4 billion yuan in 1988, an increment of 25 percent. The high-speed expansion brought serious inflation. Although in October 1988, the CPCCC decided to "govern, reorganize and reform" the over-heated economy and started to reduce the money supply, the prices still continued to rise rapidly. There were four large-scale panic purchasing rushes and the overall level of annual retail price rose by 18.5 percent in 1988. In the first quarter of 1989, the overall retail price rose by 27 percent, compared to the same period of the previous year (Chinese Price Statistics Yearbook 1990, p. 3 and 11). The inflation caused a rather short supply of producer goods. Many TVEs suspended their production because of lack of raw materials and energy. "In January and February 1989, electricity was unable to meet the demand. In some regions there was no electricity during daytime at all and electricity came only after 10 o'clock in the evening. Some supplied electricity four days and stopped three days each week. Self-generated electricity was also difficult because it was hard to buy oil, and even coal was seriously short" (Zhang, 1990, p. 349).KeywordsPrivate EnterpriseState CouncilFarm WorkerRural EconomyRural IndustryThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
A Reduced-Boron OPR1000 Core Based on the BigT Burnable Absorber (2016)

Reducing critical boron concentration in a commercial pressurized water reactor core offers many advantages in view of safety and economics. This paper presents a preliminary investigation of a reduced-boron pressurized water reactor core to achieve a clearly negative moderator temperature coefficient at hot zero power using the newly-proposed “Burnable absorber-Integrated Guide Thimble” (BigT) absorbers. The reference core is based on a commercial OPR1000 equilibrium configuration. The reduced-boron ORP1000 configuration was determined by simply replacing commercial gadolinia-based burnable absorbers with the optimized BigT-loaded design. The equilibrium cores in this study were directly searched via repetitive Monte Carlo depletion calculations until convergence. The results demonstrate that, with the same fuel management scheme as in the reference core, application of the BigT absorbers can effectively reduce the critical boron concentration at the beginning of cycle by about 65 ppm. More crucially, the analyses indicate promising potential of the reduced-boron OPR1000 core with the BigT absorbers, as its moderator temperature coefficient at the beginning of cycle is clearly more negative and all other vital neutronic parameters are within practical safety limits. All simulations were completed using the Monte Carlo Serpent code with the ENDF/B-VII.0 library.
An imaging nuclear survey system (1996)

A combined video and gamma ray imaging system has been developed which can rapidly determine the location, distribution, and intensity of gamma ray sources. This instrument includes both a conventional video camera and a gamma ray imaging system, which is based upon a position sensitive photomultiplier tube, a scintillator, and a pinhole collimator. The gamma camera records the position and energy of each interaction, determining the energy spectrum and count rate from each direction. We have used a prototype of such an instrument in preliminary field tests to image radioactive sources with gamma ray energies between 120 keV and 2.4 MeV. At 662 keV, this new system achieves an angular resolution of 4/spl deg/ FWHM with an absolute efficiency of 1/spl times/10/sup -6/ at 1 meter, with sensitivity such that a 0.5 mCi /sup 137/Cs source at 5 meters can be located in <60 seconds. Higher efficiency and sensitivity can be achieved at lower spatial resolution.
Synthesis of 6-thiosubstituted 5-ethoxycarbonyl-1,3-diphenyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-ones, 6-substituted 5-hydroxy-1,3-diphenyl-2,3-dihydrothieno[2,3-d]pyrimidin-4(1H)-ones and their esters with local anesthetic, antiarrhythmic, antiinflammatory and analgesic activities. (1998)

The synthesis of 6-thiosubstituted 5-ethoxycarbonyl-1,3-diphenyl-2-thioxo-2,3-dihydropyrimidin- 4(1H)-ones 3, and of 6-substituted 5-hydroxy-1,3-diphenyl-2,3-dihydrothieno[2,3-d]pyrimidin-4(1H)-ones 5 and their esters 6 is described. These derivatives were prepared in order to evaluate the influence on the pharmacological profile of alkyl substituents bearing polar/hydrophilic functionalities at an enethiol substructure as in compounds 3 or to assess the effects arising from the incorporation of the sulfur atom in a thiophene moiety as in thienopyrimidinones 5 and 6 in comparison with a series of 5-substituted 6-acylthio-1,3-diphenyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-ones 1c,d, previously described. Preliminary screenings suggest that all tested compounds maintained or even increased the local anesthetic activity, but failed in the platelet antiaggregating activity; on the other hand, antiarrhythmic and antiinflammatory activity was preserved in some esters 6.
Patient-Specific Polyvinyl Alcohol Phantom Fabrication with Ultrasound and X-Ray Contrast for Brain Tumor Surgery Planning (2020)

Phantoms are essential tools for clinical training, surgical planning and the development of novel medical devices. However, it is challenging to create anatomically accurate head phantoms with realistic brain imaging properties because standard fabrication methods are not optimized to replicate any patient-specific anatomical detail and 3D printing materials are not optimized for imaging properties. In order to test and validate a novel navigation system for use during brain tumor surgery, an anatomically accurate phantom with realistic imaging and mechanical properties was required. Therefore, a phantom was developed using real patient data as input and 3D printing of molds to fabricate a patient-specific head phantom comprising the skull, brain and tumor with both ultrasound and X-ray contrast. The phantom also had mechanical properties that allowed the phantom tissue to be manipulated in a similar manner to how human brain tissue is handled during surgery. The phantom was successfully tested during a surgical simulation in a virtual operating room. The phantom fabrication method uses commercially available materials and is easy to reproduce. The 3D printing files can be readily shared, and the technique can be adapted to encompass many different types of tumor.
Amplification of biomolecular interactions using liquid crystals and nanostructured surfaces (2003)

It has long been known that the orientations assumed by liquid crystals near surfaces are often controlled by a precarious and complex balance of long-ranged (e.g., electrostatic or elastic) and short-ranged (e.g., chemically-specific) interactions. These interactions are defined by the structure of surfaces over a wide range of length scales (0.1-1000 nm). Our research exploits the sensitivity of liquid crystals to the nanometer-scale structure of surfaces to amplify molecular and biomolecular interactions into optical signals. The author describes the use of liquid crystals and nanostructured surfaces to selectively amplify recognition events between proteins and their receptors into optical signals. Recent work aimed at the development of principles suitable for profiling of regulatory signaling proteins are also discussed.
Application of explicit convolution to numerical modeling of turbulent combustion (2013)

Combustion devices mostly rely on turbulent combustion to produce energy in an efficient way. Today computational power has enabled numerical modeling of these real configurations using Large Eddy Simulations(LES). However the scales at which chemical reactions occur are even smaller than the smallest flow scales and require a model. In this work we propose to use spatially filtered 1D laminar flamelet, for simulating a turbulent flame, on a grid coarser than adequate for resolution of chemical scales. A numerical simulation which resolves all the flow and chemical scales is computed as a benchmark and a priori analysis is carried out to test the hypothesis. To test the validity of the model a posteriori analysis using a laminar flame convoluted with top hat is carried out.
Exocyst-Dependent Membrane Addition Is Required for Anaphase Cell Elongation and Cytokinesis in Drosophila (2015)

Mitotic and cytokinetic processes harness cell machinery to drive chromosomal segregation and the physical separation of dividing cells. Here, we investigate the functional requirements for exocyst complex function during cell division in vivo, and demonstrate a common mechanism that directs anaphase cell elongation and cleavage furrow progression during cell division. We show that onion rings (onr) and funnel cakes (fun) encode the Drosophila homologs of the Exo84 and Sec8 exocyst subunits, respectively. In onr and fun mutant cells, contractile ring proteins are recruited to the equatorial region of dividing spermatocytes. However, cytokinesis is disrupted early in furrow ingression, leading to cytokinesis failure. We use high temporal and spatial resolution confocal imaging with automated computational analysis to quantitatively compare wild-type versus onr and fun mutant cells. These results demonstrate that anaphase cell elongation is grossly disrupted in cells that are compromised in exocyst complex function. Additionally, we observe that the increase in cell surface area in wild type peaks a few minutes into cytokinesis, and that onr and fun mutant cells have a greatly reduced rate of surface area growth specifically during cell division. Analysis by transmission electron microscopy reveals a massive build-up of cytoplasmic astral membrane and loss of normal Golgi architecture in onr and fun spermatocytes, suggesting that exocyst complex is required for proper vesicular trafficking through these compartments. Moreover, recruitment of the small GTPase Rab11 and the PITP Giotto to the cleavage site depends on wild-type function of the exocyst subunits Exo84 and Sec8. Finally, we show that the exocyst subunit Sec5 coimmunoprecipitates with Rab11. Our results are consistent with the exocyst complex mediating an essential, coordinated increase in cell surface area that potentiates anaphase cell elongation and cleavage furrow ingression.
Knockdown of the bovine prion gene PRNP by RNA interference (RNAi) technology (2007)

Four siRNA expression plasmid vectors, six target sites of bPRNP, and various lengths of siRNAs from 19 mer to 29 mer were examined to establish optimal conditions for knocking down of bPRNP in vitro. The most effective siRNA so far tested was 21 mer GGGGAGAACTTCACCGAAACT driven either by a hU6 or tRNA promoter, a finding that provides a basis for further studies in vivo.
Superficial scald, a functional disorder of stored apples X. Control of α‐farnesene autoxidation (1974)

Abstract A wide range of antioxidants (amine, phenolic and one sulphur‐containing) were all found to inhibit the autoxidation of α‐farnesene in vitro . Some were somewhat more effective than others but no class showed any marked superiority. When added to apples as a dip or by injection, only amine type antioxidants inhibited the autoxidation of α‐farnesene in vitro . Phenolic antioxidants were ineffective and some acted as pro‐oxidants, notably α‐tocopherol. In all instances the severity of superficial scald was proportional to the extent of α‐farnesene oxidation.
Multiple Intracranial Aneurysms in a Defined Population (1994)

MULTIPLE INTRACRANIAL ANEURYSMS (MIA) have been detected in up to one-third of patients with cerebral aneurysms. Three main external factors influence these figures as follows: the quality of angiographies, the quantity of vessels studied, and referral policy. In a 1-year prospective study, we determined the incidence of MIA in a defined catchment area in East Finland by investigating all of the patients with intracranial aneurysms with panangiography. In 114 unselected patients, a total of 170 intracranial aneurysms were detected, and, of these, 39 (34%) harbored MIA. In contrast to most other reports, there was a male predominance in patients with MIA, and half of these men had hypertension. Intracavernous carotid and pericallosal aneurysms were more frequent in patients with MIA. The number of asymptomatic vertebrobasilar aneurysms was extremely low, and most of the nonruptured aneurysms were found in bilateral carotid angiograms. In spite of the active search, the proportion of vertebrobasilar aneurysms remained at 6%. Although our surgical policy was most active, one-third of the asymptomatic aneurysms remained untreated, mainly because of the poor condition of the patient.
Effects of resistive load on the phase difference between chest and mouth flow in patients with chronic obstructive pulmonary disease. (1997)

The influence of the resistive load on the phase difference (PD) between chest wall and mouth flow in patients with chronic obstructive pulmonary disease (COPD) was investigated, and the factors that induce an enlargement of the PD were assessed. After a resistance tube (R = 2.8 hPa/l/s) was applied to the mouth of the subjects, the PDs increased significantly both in normal (pre: 2.20 +/- 0.89, post: 5.60 +/- 2.04, P < 0.01) and in COPD (pre: 10.86 +/- 3.81; post: 13.12 +/- 3.64, P < 0.01). A significant correlation between the airway resistance and PD was noted (r = 0.730, P < 0.001). These results suggest that airway resistance is an important determinant for the PD. The predicted phase difference (PD') was then calculated by the Runge-Kutta method, using the measured chest flow, the time domain functions of airway resistance and the thoracic gas volume during a respiratory cycle, assuming that the respiratory system was a single compartment. The PD/PD' at pre-resistive load was significantly larger in COPD than in normal subjects (normal: 1.03 +/- 0.11; COPD, 1.45 +/- 0.19, P < 0.01), whereas the PD/PD' at a post-resistive load was significantly smaller than at the pre-resistive load in COPD patients. These results agree well with the two parallel or serial compartment model with inhomogeneous airway resistance, where the mechanical property of the partitioning tissue between the two compartments was taken into account. The pattern of the increase in the work energy consumed within the airway lumen calculated from this model was almost the same as for PD. Thus, we conclude that the PD may be a good index of the overload of the respiratory movement and available to predict muscle fatigue in COPD patients.
Physico-chemical properties and organization of lipids in membranes: their possible role in myocardial injury (1987)

Lipids in biological membranes are organized in a bilayer configuration in order to form a semi-permeable barrier. The lipids are freely mobile in the bilayer, which is denoted as "fluid" or liquid-crystalline. For plasma membranes it is assumed that the lipids are not homogeneously distributed over the two leaflets or monolayers. This so-called lipid asymmetry is established for the erythrocyte membrane. There it was found that phosphatidylserine (PS) and phosphatidylethanolamine (PE) are present exclusively and predominantly in the cytoplasmic leaflet, respectively. It is shown that isolated PE at physiological conditions forms a non-bilayer configuration the so-called hexagonal HII phase. Moreover, isolated PS can undergo a transition from the fluid into the solid state upon addition of calcium. In mixtures of PS and PE, calcium is able to induce fusion events, possibly formation of the HII phase and phase separation of solid PS. The physico-chemical behaviour of these phospholipids will be discussed in the light of the structural changes of the sarcolemma of heart muscle cells observed by freeze-fracturing and thin section electron microscopy after ischaemia, ischaemia and reperfusion and the calcium paradox. The lateral phase separation of intramembranous particle aggregation is explained as isothermic phase separation by H+ and calcium. The disruption of the sarcolemma by the formation of blebs (liposomal structures) is interpreted as a destabilization of the bilayer configuration since PE prefers the HII phase and thus induces uncontrolled fusion events. This all leads to an irreversible disruption of the sarcolemma.
A new serial sensing approach for multistorage non-volatile memories (2002)

This paper presents a novel serial sensing method for multistorage non-volatile memories. The method is based on a dichotomic algorithm to detect the level stored in the memory cell selected. While maintaining the main advantage of the serial approach (the use of a single sense amplifier), the method proposed also reduces to a minimum the overall time needed to read the cell content. Sensing time is independent of the memory cell content.
Asymmetric Lewis Acid-Catalyzed Diels−Alder Reactions of α,β-Unsaturated Ketones and α,β-Unsaturated Acid Chlorides (2003)

[reaction: see text] Conformational analysis, van der Waals attractions, and transition structure calculations are combined to design an asymmetric Lewis acid-catalyzed Diels-Alder reaction for simple acyclic alpha,beta-unsaturated ketones and alpha,beta-unsaturated acid chlorides, giving up to 83 and 92% ee, respectively. The two-point-binding chiral recognition mechanism, Lewis acid-Lewis base coordination with boron and a van der Waals attraction with the naphthyl group, uses the inherent enone unit of simple alpha,beta-unsaturated carbonyl compounds, ending the need for auxiliary oxygen binding sites on the dienophile.
A novel archaeal regulatory protein, Sta1, activates transcription from viral promoters (2006)

While studying gene expression of the rudivirus SIRV1 in cells of its host, the hyperthermophilic crenarchaeon Sulfolobus, a novel archaeal transcriptional regulator was isolated. The 14 kDa protein, termed Sulfolobus transcription activator 1, Sta1, is encoded on the host chromosome. Its activating effect on transcription initiation from viral promoters was demonstrated in in vitro transcription experiments using a reconstituted host system containing the RNA polymerase, TATA-binding protein (TBP) and transcription factor B (TFB). Most pronounced activation was observed at low concentrations of either of the two transcription factors, TBP or TFB. Sta1 was able to bind viral promoters independently of any component of the host pre-initiation complex. Two binding sites were revealed by footprinting, one located in the core promoter region and the second approximately 30 bp upstream of it. Comparative modeling, NMR and circular dichroism of Sta1 indicated that the protein contained a winged helix-turn-helix motif, most probably involved in DNA binding. This strategy of the archaeal virus to co-opt a host cell regulator to promote transcription of its genes resembles eukaryal virus-host relationships.
ENHANCED DATA DISCOVERABILITY FOR IN SITU HYPERSPECTRAL DATASETS (2016)

Abstract. Field spectroscopic metadata is a central component in the quality assurance, reliability, and discoverability of hyperspectral data and the products derived from it. Cataloguing, mining, and interoperability of these datasets rely upon the robustness of metadata protocols for field spectroscopy, and on the software architecture to support the exchange of these datasets. Currently no standard for in situ spectroscopy data or metadata protocols exist. This inhibits the effective sharing of growing volumes of in situ spectroscopy datasets, to exploit the benefits of integrating with the evolving range of data sharing platforms. A core metadataset for field spectroscopy was introduced by Rasaiah et al., (2011-2015) with extended support for specific applications. This paper presents a prototype model for an OGC and ISO compliant platform-independent metadata discovery service aligned to the specific requirements of field spectroscopy. In this study, a proof-of-concept metadata catalogue has been described and deployed in a cloud-based architecture as a demonstration of an operationalized field spectroscopy metadata standard and web-based discovery service.
The capacity of orthogonal and bi-orthogonal codes on the Gaussian channel (1998)

This correspondence analyzes the performance of concatenated coding systems and modulation schemes operating over the additive white Gaussian noise (AWGN) channel by examining the loss of capacity resulting from each of the processing steps. The techniques described in this correspondence allow the separate evaluation of codes and decoders and thus the identification of where loss of capacity occurs. Knowledge of this capacity loss is very useful for the overall design of a communications system, e.g., for evaluating the benefits of inner decoders that produce information beyond the maximum-likelihood (ML) estimate. The first two sections of this correspondence provide a general technique for calculating the composite capacity of an orthogonal or a bi-orthogonal code and the AWGN channel in isolation. The later sections examine the composite capacities of an orthogonal or a bi-orthogonal code, the AWGN channel, and various inner decoders including the decoder estimating the bit-by-bit probability of a one, as is used in turbo codes. The calculations in these examples show that the ML decoder introduces a large loss in capacity. Much of this capacity loss can be regained by using only slightly more complex inner decoders, e.g., a detector for M-ary frequency-shift keying (MFSK) that puts out the two most likely frequencies and the probability the ML estimate is correct produces significantly less degradation than one that puts out only the most likely frequency.
Comparative analysis of the toxicity of gold nanoparticles in zebrafish (2018)

The use of nanoparticles - particles that range in size from 1 to 100 nm - has become increasingly prevalent in recent years, bringing with it a variety of potential toxic effects. Zebrafish embryos were exposed during the 3 day postfertilization period to gold nanospheres (GNSs), gold nanorods (GNRs), GNRs coated with polystyrene sulphate (PSS-GNRs) and GNRs coated with both PSS and polyallamine hydrochloride (PAH-PSS-GNRs). All nanorods were stabilized with cetyltrimethylammonium bromide. GNSs were the least toxic of the nanoparticles studied, with exposure resulting in no significant changes in mortality, hatching or heart rate. Exposure to GNRs and PSS-GNRs resulted in significant increases in mortality and significant decreases in hatching and heart rate. Treatment with GNRs caused significant changes in the expression of a variety of oxidative stress genes. The toxic effects of GNRs were ameliorated by coating them with PSS and, to a more marked extent, with a double coating of PSS and polyallamine hydrochloride.