gebhart/patrepeval huggingface dataset:
Modification of vincristine dosing during concomitant azole therapy in adult acute lymphoblastic leukemia patients (2009)

Caution should be used with the coadministration of vincristine and azoles. It is recommended that institutional guidelines be developed to standardize care for patients receiving vincristine with azole therapy. Potential measures to avoid this interaction include revisiting azole prophylaxis in this patient group and being judicious in azole selection.
Some observations on primary production and plankton biomass along the continental shelf and slope off the northeast coast of India during January 1989 (1996)

The present study deals with the quantitative aspects of chlorophyll pigments,&#13;\nprimary productivity and plankton biomass from the continental shelf and slope off&#13;\nthe northeast coast of India between 16° and 20°N latitudes towards the end of&#13;\nnortheast monsoon season. In surface waters, the mean values of chl-a, -b, and -c&#13;\nwere 0.249,0.275 and 0.837 mg/m^ along the shelf and 0.246,0.260 and 0.805 mg/m^&#13;\nin the slope respectively while the net primary productivity values were 0.074 and&#13;\n0.081 g C/m /d for the shelf and slope waters respectively. Column productivity in&#13;\nthe upper 0-50 m water in the shelf and slope regions were 2.9 and 3.25 g C/m /d with&#13;\nan average production of 3.08 g C/m /d. Higher rate of production was observed&#13;\naround 18° and 20°N latitudes. Zooplankton biomass exhibited progressive increase&#13;\nin volume from 16° to 20°N. The estimated mean zooplankton biomass volume of the&#13;\nstudy area was 28.83 ml/m . The mean transfer coefficient from primary to secondary&#13;\nproduction was found to be 14% when 50% of the zooplankton biomass was&#13;\nconsidered as the daily rate of production. From the mean primary and secondary&#13;\nproductivity values, potential tertiary production of pelagic fishery resources in the&#13;\nupper 0-50 m water column of the study area for the month was assessed.
La teneur du coton en fragments de graines (seed coat content): sa corrélation avec d'autres propriétés physiques (1990)

(...) 21 varietes de coton du Burundi ont ete examinees et les proprietes suivantes en ont ete deduites: - le seed coat content (rendu en nombre et en surface); - l'energie necessaire pour separer les fibres de la graine (l'energie de separation); - la resistance de la fibre (l'indice Pressley); - la resistance du tegument; - et la densite d'implantation des fibres. (...)
Thermodynamics of a fluid confined to a slit pore with structured walls (1994)

In this article we extend our previous thermodynamic analysis of films confined to slit pores with smooth walls (i.e., plane–parallel solid surfaces without molecular structure) to the situation in which the walls themselves possess structure. Structured-wall models are frequently employed to interpret experiments performed with the surface forces apparatus (SFA), in which thin films (1–10 molecular diameters thick) are subjected to shear stress by moving the walls laterally over one another at constant temperature, chemical potential, and normal stress or load. The periodic structure of the walls is reflected in a periodic variation of the shear stress with the lateral alignment (i.e., shear strain) of the walls. We demonstrate by means of a solvable two-dimensional model that the molecular length scale imposed by the structure of the walls precludes the derivation of a simple mechanical expression for the grand potential analogous to that which holds in the smooth-wall case. This conclusion is borne out by the results of a grand-canonical Monte Carlo simulation of the three-dimensional prototypal model consisting of a Lennard-Jones (12,6) fluid confined between fcc (100) walls. Criteria for the thermodynamic stability of thin films confined by structured walls are derived and applied to the SFA.
Pericellular Ca2+recycling potentiates thrombin-evoked Ca2+signals in human platelets (2013)

We have previously demonstrated that Na(+)/Ca(2+) exchangers (NCXs) potentiate Ca(2+) signaling evoked by thapsigargin in human platelets, via their ability to modulate the secretion of autocoids from dense granules. This link was confirmed in platelets stimulated with the physiological agonist, thrombin, and experiments were performed to examine how Ca(2+) removal by the NCX modulates platelet dense granule secretion. In cells loaded with the near-membrane indicator FFP-18, thrombin stimulation was observed to elicit an NCX-dependent accumulation of Ca(2+) in a pericellular region around the platelets. To test whether this pericellular Ca(2+) accumulation might be responsible for the influence of NCXs over platelet function, platelets were exposed to fast Ca(2+) chelators or had their glycocalyx removed. Both manipulations of the pericellular Ca(2+) rise reduced thrombin-evoked Ca(2+) signals and dense granule secretion. Blocking Ca(2+)-permeable ion channels had a similar effect, suggesting that Ca(2+) exported into the pericellular region is able to recycle back into the platelet cytosol. Single cell imaging with extracellular Fluo-4 indicated that thrombin-evoked rises in extracellular [Ca(2+)] occurred within the boundary described by the cell surface, suggesting their presence within the open canalicular system (OCS). FFP-18 fluorescence was similarly distributed. These data suggest that upon thrombin stimulation, NCX activity creates a rise in [Ca(2+)] within the pericellular region of the platelet from where it recycles back into the platelet cytosol, acting to both accelerate dense granule secretion and maintain the initial rise in cytosolic [Ca(2+)].
Automated electrochemical selection of coliforms (1978)

Computer-controlled sensor system monitors and quantifies coliform organisms in waste water samples through molecular hydrogen detection techniques. System includes cleanup procedures, external sterilization of each sensor interface with working fluid as well as incubation cell interiors. Sensor system may also be operated manually.
Cover Picture (2001)

The cover picture shows a major breakthrough in synthetic biostructural chemistry that has been achieved through the fruitful collaboration of Italian and Swiss research groups. The depicted prototypic template structure, which has been determined in the crystalline state (and also by 1H NMR spectroscopy in solution), can serve as a molecular vehicle for the accommodation of functional protein fragments as well as mere side chains by chemical modification according to the template-assembled synthetic protein (TASP) concept developed by Mutter and co-workers. The template constitution is accessible and modularly variable by standard methods of chemical synthesis according to general procedures described previously. The presently chosen stereochemistry is parented by the structure of the natural antibiotic gramicidin S which has been engineered into the presented aromatically substituted heterochiral cyclodecapeptide with antiparallel β strands spanned by type II′ β turns. For more details see the article by Mutter, Crisma et al. on p. 432 ff. (Elements and conception of the cover illustration by Christian Lehmann, University of Lausanne.)
Bacterial Autoimmune Drug Metabolism Transforms an Immunomodulator into Structurally and Functionally Divergent Antibiotics (2020)

Abstract Tapinarof is a stilbene drug that is used to treat psoriasis and atopic dermatitis, and is thought to function through regulation of the AhR and Nrf2 signaling pathways, which have also been linked to inflammatory bowel diseases. It is produced by the gammaproteobacterial Photorhabdus genus, which thus represents a model to probe tapinarof structural and functional transformations. We show that Photorhabdus transforms tapinarof into novel drug metabolism products that kill inflammatory bacteria, and that a cupin enzyme contributes to the conversion of tapinarof and related dietary stilbenes into novel dimers. One dimer has activity against methicillin‐resistant Staphylococcus aureus (MRSA) and vancomycin‐resistant Enterococcus faecalis (VRE), and another undergoes spontaneous cyclizations to a cyclopropane‐bridge‐containing hexacyclic framework that exhibits activity against Mycobacterium . These dimers lack efficacy in a colitis mouse model, whereas the monomer reduces disease symptoms.
Evolution on a desert island: body size divergence between the reptiles ofNevada'sAnahoIsland and the mainland aroundPyramidLake (2013)

Abstract Patterns of body size evolution on islands provide compelling cases of rapid and dramatic phenotypic evolution in terrestrial vertebrates, yet debate remains over the relative roles of predation and resource availability in driving such evolution. We compared the morphology of five reptile species (four lizards, one snake) from A naho I sland, a desert island in P yramid L ake, Nevada, and the nearby mainland, using museum and live‐caught animals. We also examined head‐shape allometries to make inferences about dietary shifts and recorded tail‐regeneration frequencies (in lizards) to examine predation intensity. Compared with mainland samples, two phyrnosomatid lizard species are larger on A naho ( C allisaurus draconoides and S celoporus occidentalis ), whereas the largest ( S . uniformis ) is not different on the island. Conversely, the teiid lizard A spidoscelis tigris is smaller in body and head size on the island, and the pitviper C rotalus oreganus is especially diminutive on the island, with males and females 25 and 15% smaller, respectively. Our results appear consistent with the hypothesis that body size is related to resource availability. The change in body size of the two smaller phrynosomatids may be due to interference competition. The reduction in body and head size in A . tigris suggests a dietary shift, and the dramatic difference in C . oreganus is likely due to a switch in diet from mammals to lizards. Future work is needed to determine whether body size differences reflect genetic evolution or environmental differences in growth rates or resource use. Regardless, A naho I sland, although remarkably young (early H olocene), appears to harbour a unique community of reptiles with distinct morphologies and possibly divergent life histories.
Secure transaction processing in firm real-time database systems (1997)

Many real-time database applications arise in safety-critical installations and military systems where enforcing security is crucial to the success of the enterprise. A secure real-time database system has to simultaneously satisfy who requirements guarantee data security and minimize the number of missed transaction deadlines. We investigate here the performance implications, in terms of missed deadlines, of guaranteeing security in a real-time database system. In particular, we focus on the concurrency control aspects of this issue.
Pharmacology and Toxicology of Ibuprofen (1999)

Ibuprofen is typical of the class of nonsteroidal anti-inflammatory drugs and has anti-inflammatory, analgesic and antipyretic activities. In the early stages of the development of the acute inflammation there is increased vascular permeability and mast cell degranulation with accompanying release of histamine and 5-hydroxytryptamine within 10–15 min. The initial phase of inflammation induced by subplantar injection of carrageenan results only in a small degree of footpad swelling due to accumulation of fluid. The acute anti-inflammatory effects of ibuprofen in the carrageenan paw oedema model show that this drug is appreciably more potent than aspirin and phenylbutazone, but less so than indomethacin. Plasma iron concentrations usually decline in adjuvant arthritis as part of the systemic acute-phase response to the disease. Intrathecal ibuprofen has been shown to be 1.4 times more potent as an analgesic than aspirin and 10 times less so than indomethacin.
A Haar wavelet-based scheme for finding the control parameter in nonlinear inverse heat conduction equation (2021)

Abstract In this article, a hybrid Haar wavelet collocation method (HWCM) is proposed for the ill-posed inverse problem with unknown source control parameters. Applying numerical techniques to such problems is a challenging task due to the presence of nonlinear terms, unknown control parameter sources along the solution inside the given region. To find the numerical solution, derivatives are discretized adopting implicit finite-difference scheme and Haar wavelets. The computational stability and theoretical rate of convergence of the proposed HWCM are discussed in detail. Two numerical experiments are incorporated to show the well-condition behavior of the matrix obtained from HWCM and hence not required to supplement some regularization procedures. Moreover, the numerical solutions of the considered experiments illustrate the reliability, suitability, and correctness of HWCM.
Which Patient is Most Likely to Benefit from a Rate Responsive Pacemaker? (1988)

In order to provide information about indications for rate responsive pacing, we examined the exercise capacity of a typical collective of pacemaker patients. One hundred seven patients participated in the study, 50/107 (46.8%) suffered from sick sinus syndrome, 37/107 (34.6%) showed complete AV block, 12/107 (11.2%) had bradyarrhythmia and 8/107 (7.4%) had other diseases. All patients underwent treadmill exercise with increasing workloads up to the individual's maximum workload. We monitored heart rate, respiratory rate, workload, the subjective perception of stress according to the Borg scale, and the reason for the termination of exercise. Calculation of oxygen uptake was done according to an equation given by Givoni. During the tests, all implanted pacemakers have been programmed to VVI 70 mode. We found that all pacemaker patients showed a reduction of their exercise capacity compared to the age-related normal values. Particularly in patients with AV block or bradyarrhythmia, the maximum achievable workload often did not even reach levels of everyday activities such as going upstairs; patients with sick sinus syndrome showed slightly better exercise capability, probably due to the higher increase of average heart rate. Despite objective differences of maximum workload, all patients had the same subjective perception at the end of the tests; the course of respiratory rate indicated that all persons finished the tests in the range of individual maximum exercise capacity.(ABSTRACT TRUNCATED AT 250 WORDS)
Synthesis, Crystal Structures, and Magnetic Properties of Two New 1D Copper(II) Coordination Polymers Containing Fumarate(−2) and Chelating N,N′-Donor as Ligands (2002)

Two new polynuclear complexes of CuII, [Cu2(fum)(μ-OH)(bpy)2(H2O)](NO3)·2H2O (1) (fum = fumarate dianion, bpy = 2,2′-bipyridine) and [Cu(fum)(tmen)]·2H2O (2) (tmen = N,N,N′,N′-tetramethylethane-1,2-diamine), have been synthesized and structurally characterized by X-ray crystallography. Complex 1, C24H27Cu2N5O12, crystallizes in a triclinic system, space group P , with a = 10.168(14), b = 11.347(14), c = 14.74(2) Å, and Z = 2; complex 2, C10H22CuN2O6, crystallizes in an orthorhombic system, space group Pbca, with a = 14.701(19), b = 14.899(19), c = 26.90(3) Å, and Z = 16. Compound 1 is an alternating chain compound, with alternate repetition of bis(monodentate) (μ2) and bis(bidentate) (μ4) bridging modes of fumarate, showing ferromagnetic interaction between CuII ions through hydroxo bridges with a Cu−O−Cu angle of 108.5°. Compound 2 is a linear 1D zig-zag polymer. There are two copper(II) ions with equivalent coordination and geometry in the asymmetric unit, each of them bonded to a bidentate tmen ligand and to two different fumarate moieties. Magnetic susceptibility data were measured in the 300−2 K temperature range. The magnetic data for 1 were fitted by use of a ferromagnetic/antiferromagnetic alternating S = 1/2 chain system and show the following results: JF = +5.4 cm−1, JAF = −0.25 cm−1, g = 1.96. The susceptibility data of 2 were fitted by use of the Bonner−Fisher expression for antiferromagnetically coupled S = 1/2 local spins, giving the parameters J = −1.81 cm−1, g = 2.03.
Trust region-based optimization of PKI neural models for RF/microwave devices (2012)

This article proposes a new trust region-based optimization technique for Radio Frequency (RF)/microwave devices. The proposed approach is apt for modeling scenarios, where standard ANN multilayer perceptron (MLP) and Prior Knowledge Input (PKI) models fail to deliver a satisfactory model. This approach feeds output of standard ANN model as knowledge input to PKI model. The ANN model and the PKI model form a symbiotic pair to yield accurate results. In this paper, the dogleg routine is exploited in the process of optimization to obtain valid trust region steps. The proposed method is compared with sensitivity technique via several RF/microwave components. © 2012 Wiley Periodicals, Inc. Int J RF and Microwave CAE, 2013.
HDBExpDetector: Aggregate Sudden-Change Detector over Dynamic Web Databases (2017)

We propose to demonstrate HDBExpDetector, a system for analysts to discover bursty events from a thirdparty web database by using nothing but the existing search interface of the web database to monitor and detect sudden changes to aggregates that satisfy certain user-defined conditions. Video https://youtu.be/7Pwd8o1h5CY.
Comparison of cerebrovascular effects of intravenous cocaine injection in fetal, newborn, and adult sheep (2000)

Cocaine may cause stroke, intracranial hemorrhage, seizures, and neurobehavioral abnormalities in fetuses, newborns, and adults, and there could be developmental and/or species differences in mechanisms for these cocaine-induced cerebrovascular effects. To evaluate developmental differences in responses to cocaine, we compared the cerebrovascular and metabolic responses to a 2 mg/kg iv cocaine dose in unanesthetized fetal (n = 8, previously reported, direct fetal injection), newborn (n = 6), and adult (n = 12) sheep. We measured cerebral blood flow, mean arterial blood pressure, and arterial and venous O(2) content, and we calculated cerebral O(2) consumption and cerebral vascular resistance at baseline and at 30 s and at 5, 15, and 60 min after cocaine injection. Cerebral blood flow increased 5 min after injection in the fetus and newborn, but not until 15 min in the adult. In the fetus, cocaine caused a transient cerebral vasoconstriction at 30 s; in all three groups, cocaine caused cerebral vasodilation, which was delayed in the adult. Cerebral metabolic O(2) consumption increased 5 min after injection in the fetus and newborn, but not until 15 min after injection in the adult. Arterial O(2) content decreased 5 min after injection in the fetus and 15 min after injection in the adult. We speculate that clinical differences in response to cocaine injection may be explained, in part, by these developmental differences in the cerebrovascular and metabolic responses to cocaine.
Supplementary Figure 1 from Baseline Circulating Tumor Cell Counts Significantly Enhance a Prognostic Score for Patients Participating in Phase I Oncology Trials (2023)

&lt;p&gt;PDF file - 1129K, Baseline duplicate CTC counts correlation&lt;/p&gt;
Chemoselective mechanism of (Z)-1,3-pentadiene polymerization in the presence of cyclopentadienyltitanium trichloride and methylaluminoxane (1998)

Comparative polymerizations of 4,5,5,5-d4-(Z)-1,3-pentadiene at different temperatures in the presence of CpTiCl3-MAO have shown that the chemoselectivity and its temperature dependence (1,2 or 1,4 polymerization at low or high temperatures, respectively) are not influenced by deuteration of the monomer. This suggests the absence of any relevant role of H-agostic interactions between the growing chain-end and the metal, in determining chemoselectivity and rate of polymerization. Copolymerizations of (Z)-1,3-pentadiene with ethylene at −20°C give random copolymers containing substantial amounts of cis-1,4-pentadiene units adjacent to ethylene. This indicates a relevant role of the growing chain-end in determining the chemoselectivity of the insertion of the incoming monomer. A polymerization mechanism involving a back-biting coordination (a simultaneous coordination of the allyl terminal and of the last double bond) of the growing chain is proposed.
Automatic target detection using dualband infrared imagery (2002)

An automatic target detector often produces too many false alarms that could bog down the performance of a subsequent target classifier. Therefore, we need a good clutter rejector to remove as many clutterers as possible, before feeding the most likely target detections to the classifier. We investigate the benefits of using dual-band forward-looking infrared images to improve the performance of an eigen-neural based clutter rejector. With individual or combined bands as input, we use either principal component analysis or the eigenspace separation transform to perform feature extraction and dimensionality reduction. The transformed data is then fed to a properly trained multilayer perceptron that predicts the identity of the input, which is either a target or clutter. Experimental results are presented on a dataset of real dualband images.
How certain are we that our automated driving system is safe? (2023)

If results show that the uncertainty is too high, the proposed method allows answering questions like "How much more data do we need?" or "How many more (virtual) simulations must be conducted?" Therefore, the method can be used to set requirements on the amount of data and the number of (virtual) simulations. For a reliable risk estimate, though, much more data are needed than those used in the case study. Furthermore, because the method relies on (virtual) simulations, the reliability of the result depends on the validity of the models used in the simulations. The presented case study illustrates that the proposed method is able to quantify the uncertainty of the estimated safety risk of an ADS. Future work involves incorporating the proposed method into the type approval framework for future ADSs of SAE levels 3, 4, and 5, as proposed in the upcoming European Union implementing regulation for ADS.
Technical Description of the Adaptive Suspension Vehicle (1990)

This paper contains descriptions and specifications of the major mechanical systems of the Adaptive Suspension Vehi cle. It also contains an overview of the computer software and hardware architectures. Experimental response curves for the principal servo systems are presented.
Semiautonomous Vehicle Risk Analysis: A Telematics‐Based Anomaly Detection Approach (2018)

The transition to semiautonomous driving is set to considerably reduce road accident rates as human error is progressively removed from the driving task. Concurrently, autonomous capabilities will transform the transportation risk landscape and significantly disrupt the insurance industry. Semiautonomous vehicle (SAV) risks will begin to alternate between human error and technological susceptibilities. The evolving risk landscape will force a departure from traditional risk assessment approaches that rely on historical data to quantify insurable risks. This article investigates the risk structure of SAVs and employs a telematics-based anomaly detection model to assess split risk profiles. An unsupervised multivariate Gaussian (MVG) based anomaly detection method is used to identify abnormal driving patterns based on accelerometer and GPS sensors of manually driven vehicles. Parameters are inferred for vehicles equipped with semiautonomous capabilities and the resulting split risk profile is determined. The MVG approach allows for the quantification of vehicle risks by the relative frequency and severity of observed anomalies and a location-based risk analysis is performed for a more comprehensive assessment. This approach contributes to the challenge of quantifying SAV risks and the methods employed here can be applied to evolving data sources pertinent to SAVs. Utilizing the vast amounts of sensor-generated data will enable insurers to proactively reassess the collective performances of both the artificial driving agent and human driver.