gebhart/patrepeval huggingface dataset:
Data from Nab-Paclitaxel Is an Active Drug in Preclinical Model of Pediatric Solid Tumors (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; To investigate the antitumor effect of nab-paclitaxel, an albumin-stabilized nanoparticle formulation of paclitaxel, on pediatric solid tumor models.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; A panel of three rhabdomyosarcoma, one osteosarcoma and seven neuroblastoma cell lines were exposed to increasing concentrations of nab-paclitaxel &lt;i&gt;in vitro&lt;/i&gt;. Cell viability was evaluated using the Alamar Blue Assay. Antitumor effect was further assessed &lt;i&gt;in vivo&lt;/i&gt; in NOD/SCID xenograft and metastatic neuroblastoma mouse models. Tumor sections were analyzed by immunohistochemistry for cleaved caspase-3 and phospho-histone H3. Plasma and intratumoral paclitaxel concentrations were measured by liquid chromatography–mass spectrometry. Ratio of intratumoral and plasma concentration was compared between nab-paclitaxel and paclitaxel treatment groups.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Nab-paclitaxel displayed significant cytotoxicity against most pediatric solid tumor cell lines &lt;i&gt;in vitro&lt;/i&gt; in a dose-dependent manner. &lt;i&gt;In vivo&lt;/i&gt;, nab-paclitaxel showed antitumor activity in both rhabdomyosarcoma (RH4 and RD) and neuroblastoma [SK-N-BE(2) and CHLA-20] xenograft models. In the SK-N-BE(2) metastatic model, nab-paclitaxel treatment significantly extended animal survival compared with control (&lt;i&gt;P&lt;/i&gt; &lt; 0.01). Nab-paclitaxel treatment induced tumor cell-cycle arrest and apoptosis &lt;i&gt;in vivo&lt;/i&gt;. In the RH4 model, increased local relapse-free intervals were observed with nab-paclitaxel treatment (37.7 ± 3.2 days) comparing with paclitaxel (13.6 ± 2.07 days). Local relapsed tumors following paclitaxel treatment proved to be paclitaxel-resistant and remained responsive to nab-paclitaxel. Mechanistically, a higher tumor/plasma paclitaxel drug ratio in favor of nab-paclitaxel was observed.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Nab-paclitaxel showed significant antitumor activity against all pediatric solid tumors associated with an enhanced drug intratumor delivery. Furthermore, testing of nab-paclitaxel in pediatric solid-tumor patient population is under development. &lt;i&gt;Clin Cancer Res; 19(21); 5972–83. ©2013 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Data Communication Control Procedures (1972)

article Free Access Share on Data Communication Control Procedures Author: Byron W. Stutzman Computer System Architects Incorporated, Cambridge, Massachusetts Computer System Architects Incorporated, Cambridge, MassachusettsView Profile Authors Info & Claims ACM Computing SurveysVolume 4Issue 4Dec. 1972 pp 197–220https://doi.org/10.1145/356608.356609Published:01 December 1972Publication History 22citation753DownloadsMetricsTotal Citations22Total Downloads753Last 12 Months31Last 6 weeks5 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Effects of AA‐861 and ONO‐1078 on HCl/ethanol‐induced Gastric Mucosal Lesions in Mice: Peptide Leukotriene‐mediated Tissue Injury (1995)

Gastric lesions induced by HCl/ethanol were attenuated by pretreatment of mice with AA-861 (2-(12-hydroxydodeca-5,10-diynyl)-3,5,6-trimethyl-1,4-benzoquinone), a selective inhibitor of 5-lipoxygenase.



Pretreatment with ONO-1078 (4-oxo-8-(p-(4-phenylbutyloxy)benzoylamino)-2-(tetrazol-5-yl)-4H-l-benzopyran hemihydrate), a potent antagonist of sulphidopeptide leukotrienes, also attenuated HCl/ethanol-induced gastric lesions in a dose-dependent manner. Acute gastric mucosal injury caused by oral administration of HCl/ethanol was closely associated with early vascular injury and increased vascular permeability in the gastric mucosa. Gastric mucosal lesions induced by HCl/ethanol were also associated with significant mucosal mast cell degranulation.



These results suggest that leukotrienes derived from mast cells are involved in the formation of HCl/ethanol-induced gastric lesions in mice.
<title>Flat, thinned scientific CCDs</title> (1994)

One shortcoming of large area, thinned scientific CCDs has been their lack of planarity. Areas of the silicon membrane that lie outside the depth of focus of the optical system lose resolution and cause a distorted image. Reticon has developed a thinning procedure that eliminates the ripples and bow often seen in thinned CCDs. This paper discusses the thinning procedure used to produce a flat, thinned, 2048 x 2048 pixel scientific CCD. The pixels are 13.5 micrometers square, making the image area of the CCD larger than 1' on a side. The final silicon membrane is between 16 and 18 micrometers thick and is flat to less than 5 micrometers peak-to- peak across the imaging area. Frontside devices have demonstrated a low dark current of 50 pa/cm<SUP>2</SUP> at 20 C and full well of 120k electrons when the CCD is run in MPP mode. The charge transfer efficiency exceeds 0.99999 and the readout noise is less than 2.5 electrons when the CCD is operated at 20 kHz.
Testing of steep convex aspheric surface with a Hartmann sensor by using a CGH (2006)

Most aspheric surfaces have been tested by interferometer with some null correctors. This approach, however, often fails when there are many aspherical terms or test surface is very steep because it is not easy to design the conventional null lens or CGH (Computer Generated Hologram). On the other hand, 3-D profilometer can measure aspheric surfaces without any null correctors; however, it takes some time to measure, which makes it unsuitable for the production line in the factory. In this paper, we apply the Hartmann test to the measurement of steep convex aspheric surfaces of which diameter is about 16 mm. In order to increase the measurement accuracy, we calibrated the test setup using a CGH that simulates the ideal test surface. We demonstrated that the significant amount of error in the test setup could be removed by this calibration process. The test results showed only 2 nm rms WFE (wave front error) difference even though the WFE of test setup was worsened by more than 0.13 mum rms. Since this method makes it possible to measure highly aspheric surface quickly and accurately, it can be used in the production line.
Malignant transformation of a tracheal chondroma: The second reported case and review of the literature (2016)

Tracheal tumors are rare, representing only 0.2% of the respiratory tract malignancies. Chondrosarcoma arising in the trachea was first described in 1959 by Jackson et al. and since then only 20 cases have been described. We report the second documented case of malignant transformation from an endotracheal chondroma, in a 75-year-old woman, and review the literature.
A pendulum experiment on added mass and the principle of equivalence (2007)

The concept of added mass in fluid mechanics has been known for many years. A familiar example is the accelerated motion of a sphere through an ideal (inviscid and irrotational) fluid, which has an added mass equal to one-half the mass of the fluid displaced. The period of oscillation of a simple pendulum in a vacuum is independent of its mass because of the equivalence of gravitational and inertial masses. In contrast, in a fluid both buoyancy and added mass affect the period. We present experimental results on simple pendula of different materials oscillating in various fluids. The results agree fairly well with the results obtained for the added mass in an ideal fluid.
Tandem Cross‐Dimerisation/Oxonia‐Cope Reaction of Carbonyl Compounds to Homoallylic Esters and Lactones (2012)

Konzeptionell anders: Diese Allylübertragung wird durch Lewis-Säuren (LA) katalysiert und verläuft über atomökonomische Disproportionierungen von Carbonylgruppen in organisierten Oxonia-Cope-Übergangszuständen (siehe Schema). Eine stereoselektive [n+4]-Ringerweiterung führt zu einer Vielzahl von Macroliden mit 9- bis 16-gliedrigen Ringen.
Macroscopic Human Behavior Interpretation Using Distributed Imager and Other Sensors (2008)

This paper presents BScope, a new system for interpreting human activity patterns using a sensor network. BScope provides a runtime, user-programmable framework that processes streams of timestamped sensor data along with prior context information to infer activities and generate appropriate notifications. The users of the system are able to describe human activities with high-level scripts that are directly mapped to hierarchical probabilistic grammars used to parse low-level sensor measurements into high-level distinguishable activities. Our approach is presented, though not limited, in the context of an assisted living application in which a small, privacy-preserving camera sensor network of five nodes is used to monitor activity in the entire house over a period of 25 days. Privacy is preserved by the fact that camera sensors only provide discrete high-level features, such as motion information in the form of image locations, and not actual images. In this deployment, our primary sensing modality is a distributed array of image sensors with wide-angle lenses that observe people's locations in the house during the course of the day. We demonstrate that our system can successfully generate summaries of everyday activities and trigger notifications at runtime by using more than 1.3 million location measurements acquired through our real home deployment.
Security Challenges of IoT and Medical Devices in Healthcare (2020)

The dependence of healthcare on networked IoT and medical devices has resulted in new security requirements. This chapter identifies some of these specific issues and discusses various approaches for mitigating security concerns. A classification system based on CVSS (common vulnerability scoring system) is presented. The technology applied is wide-ranging, including the integration of multi-vendor systems, AI/ML (artificial intelligence/machine learning), the use of multiple database resources such as NVD/CVE and FDA.
The Inactivation of Enzymes by Ultraviolet Light. V. The Disruption of Specific Cystines in Ribonuclease (1965)

Ken L. Grist, Thomas Taylor, Leroy Augenstein, The Inactivation of Enzymes by Ultraviolet Light. V. The Disruption of Specific Cystines in Ribonuclease, Radiation Research, Vol. 26, No. 2 (Oct., 1965), pp. 198-210
Editorial (2020)

The Journal of International Humanitarian Legal Studies was founded with the aim of exploring and examining the role of international law in all aspects of humanitarian crises, both natural and those resulting from human action (or inaction).This approach to humanitarian legal studies encompasses a number of distinct but interconnected fields of international law, including human rights, refugee law, the law of armed conflict, disarmament and arms control, international criminal law, and the role of law in preventing and responding to humanitarian disasters.In this edition of the Journal, the role of international law in situations of armed conflict is of specific focus.The first article comes from Karolina Aksamitowska, who explores the similarities and differences between current international humanitarian law principles, and traditional African laws of war.Employing a twail approach, she examines the various laws of war evidenced in traditional African societies, ultimately arguing that ihl and African traditions of law in war are markedly similar, and that these similarities could assist in dissemination and enforcement efforts in the region.The second article, by Cedric Cotter and Ellen Policinski, provides a review and analysis of one of the foundational journals in international humanitarian law -the International Review of the Red Cross.Cotter and Policinski examine the history of the Review over its 150-year life span, reflecting on its centrality to the study and practice of international humanitarian law, and how the Review serves as a history of ihl in itself.Rob Grace's article explores how humanitarian laws, principles, and practitioners are perceived by those involved in armed conflicts, specifically in the context of implementation programs of humanitarian assistance and protection.Drawing on the practice of governments, non-State armed groups, and civil society actors, Grace employs social science techniques to analyse the factors that drive patterns of compliance and non-compliance with ihl.The next article comes from Hyeran Jo, who engages with the burgeoning literature on the concept of an international rule of law, applying it to the
Role of oxygen vacancies and interstitials on structural phase transition, grain growth, and optical properties of Ga doped TiO2 (2018)

A systematic study on the effect of gallium (Ga) doping (0 ≤ x ≤ 0.10) on the structural phase transition and grain growth of TiO2 is reported here. X-ray diffraction spectroscopy and Raman spectroscopy confirm that Ga doping inhibits the phase transition. Activation energy increases from 125 kJ/mol (x = 0.00) to 300 kJ/mol (x = 0.10) upon Ga incorporation. X-ray photoelectron spectroscopy shows the presence of Ti3+/Ga3+ interstitials, substitution (Ti4+ by Ga3+), and oxygen vacancies in the samples. At lower doping (x ≤ 0.05), interstitials play a more significant role over substitution and oxygen vacancies, thereby resulting in a considerable lattice expansion. At higher doping (x ≥ 0.05), the effect of interstitials is compensated by both the effect of substitution and oxygen vacancies, thereby resulting in relatively lesser lattice expansion. Inhibition of the phase transition is the result of this lattice expansion. The crystallite size (anatase) and particle size (rutile) both are reduced due to Ga incorporation. It also modifies optical properties of pure TiO2 by increasing the bandgap (from 3.06 to 3.09 eV) and decreasing the Urbach energy (from 58.59 to 47.25 meV). This happens due to regularization of the lattice by the combined effect of substitution/interstitials and oxygen vacancies.
A Preliminary Implementation for Vehicle Platoon Control System (1991)

This paper presents an implementation of automatic longitudinal control system for a platoon of vehicles. The goal of the control is to maintain vehicle spacings to within several feet, resulting in a substantial increase in a highway capacity. The objective of the paper is to demonstrate the feasibility of this idea by field tests with two vehicles. The authors have integrated all elements of the control system using readily available equipment. The importance of the platoon communication scheme is explained, and experimental results are used to illustrate how the system works.
Understanding Patient Experience in Biliary Tract Cancer: A Qualitative Patient Interview Study (2021)

Patients with BTC reported a range of signs/symptoms and impacts that negatively affect daily functioning and HRQoL.
Collaborative Poetics Network: A Pilot Study Exploring the Potential of Collaborative, Arts-based Research (2018)

This paper presents the findings from a pilot study, conducted as part of a wider network activity to realise the potential of Collaborative Poetics (CP). CP isa participatoryarts-based research method, informed by the combined expertise of artists and academics, and by co-researchers’ lived experiences.The methodhas generated widespread interest, inspiring scholars from multiple disciplines, arts practitioners, representatives from local government/third sector groups, and business professionals. We describe the activities of a core CP network, who met to developmethodological resourcesin a series ofaction-oriented, collaborativeworkshops, which sought to embody CP principlesand practice. Two activities are shared. These were workshoppedby individuals from wide-ranging academic and artistic backgrounds,with a view to considering both a personal, reflexive response, and the wider application and development of CP methods. Insights from these pilot workshops are used to explore effective collaborative working across wide-ranging fields and sectors, to examineinteractivity issues with the pilot activities, and to highlight possibilities for further refinement and development. We conclude by looking forward to the next stages of the project and resource development, with a view toexploring the transferability of these resources into new business, education and community contexts.
Impact of 5-HTTLPR Polymorphism on Alexithymia in Alcoholic Patients After Detoxification Treatment (2013)

Mandelli, Laura PsyD, PhD; Marangoni, Ciro MD; Liappas, Ioannis MD; Albani, Diego PhD; Forloni, Gianluigi PhD; Piperi, Christina MD; Zisaki, Aikaterini MD; Tzavellas, Elias O. MD; Rodilossi, Serena PhD; Batelli, Sara PhD; Biella, Gloria PhD; Balestri, Martina MD; Kalofoutis, Anastasios PhD; De Ronchi, Diana MD, PhD; Serretti, Alessandro MD, PhD Author Information
Screening for phyto‐toxic contaminants in an industrial source of nutrients intended for foliar and root fertilization (1993)

Abstract Plant screening assays were used to determine whether significant levels of growth inhibitory and phytotoxic contaminants were present in a new industrial source of potassium dihydrogen phosphate fertilizer intended for foliar and root application. Maize (Zea mays L.) plants hydroponically cultured in a controlled environment chamber, were used for the assays. The threshold concentration of industrial potassium phosphate which just caused burn damage symptoms, when applied as standard droplets to the leaf surface with Tween 80 wetting agent was 0.5M. The comparative threshold concentration for damage by an ultrapure analytical grade of potassium phosphate was >0.6M. Thus, the industrial grade had slightly higher toxicity for leaf application. Effects on plants of supplying industrial and analytical grade phosphates via the roots were also compared. Root and leaf elongation kinetics, mature leaf cell lengths, apparent capacity for leaf cell production, shoot ontogeny, and shoot fresh weight yields were determined at low and high potassium phosphate concentrations. The effects of analytical and industrial grade fertilizer salts were equivalent. We suggest that these rapid and relatively simple plant screening assays can provide a useful safety check, prior to large scale field trails, for fertilizer nutrients produced by new industrial processes.
Targeting the trehalose utilization pathways ofMycobacterium tuberculosis (2015)

Tuberculosis (TB) is an epidemic disease and the growing burden of multidrug-resistant (MDR) TB world wide underlines the need to discover new drugs to treat the disease. <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>) is the etiological agent of most cases of TB. <i>Mtb</i> is difficult to treat, in part, due to the presence of a sturdy hydrophobic barrier that prevents penetration of drugs through the cell wall. <i>Mtb</i> can also survive in a non-replicative state for long periods of time avoiding the action of common antibiotics. Trehalose is an essential metabolite in mycobacteria since it plays key roles in cell wall synthesis, transport of cell wall glycolipids, and energy storage. It is also known for its stress protective roles such as: protection from desiccation, freezing, starvation and osmotic stress in bacteria. In this review we discuss the drug discovery efforts against enzymes involved in the trehalose utilization pathways (TUPs) and their likelihood of becoming drug targets.
Effect of heating and frozen storage on the level of native, apo and cobalt, copper, manganese and chromium complexed buffalo milk lactoferrin (1990)

Preparation de complexes metalliques de lactoferrine de buffle isole a partir de colostrum de bufflonne. Inactivation de la proteine, induite par la chaleur et le refroidissement, mesuree par electrophorese
Practical considerations for territorial perfusion mapping in the cerebral circulation using super‐selective pseudo‐continuous arterial spin labeling (2019)

Optimized labeling efficiency resulted in increased image quality and accuracy of territorial perfusion fraction maps. Labeling efficiency depends critically on off-resonance calibration, cardiac triggering, optimal label rotation scheme, and vessel location tracking.
Aberration losses of the microoptic directional coupler (1980)

A theoretical analysis of the aberration losses of the microoptic directional coupler recently being used in optical communication systems has been carried out. We show that our results are consistent with those obtained experimentally and that the minimum insertion loss does not occur at the paraxial length (which has been used in the experiments), but at an optimum length, which is slightly less. However, the tolerance in the positioning of the output fiber is less for the optimum length than for the paraxial length, although the increased loss at the optimum length due to poor positional adjustments within the tolerance value is still considerably smaller than the minimum loss at the paraxial length.
Effects of waste management on the impact of fusion power (1978)

Throughputs and inventories of radioactive materials that would have to be managed by a country whose primary form of electrical generation is fusion are estimated. Whole body dose rates for the entire population due to normal and off-normal incidents are calculated. For the case of equilibrium systems, two fusion cases are compared to an advanced fission power case. Comparisons are made for various stages of the fuel cycle and activated materials cycles. Fission reactor radiological impact is dominated by fuel reprocessing facility releases. These releases will decrease significantly if methods of containing /sup 85/Kr are implemented. Tritium releases during normal plant operations comprise most of the radiologic impact for both fusion cases. Total dose rates are estimated to be roughly two orders of magnitude lower for fusion than for fission reactors.
Low-Fat, Low-Glycemic Load Diet and Gene Expression in Human Prostate Epithelium: A Feasibility Study of Using cDNA Microarrays to Assess the Response to Dietary Intervention in Target Tissues (2007)

A 6-week, low-fat/low-glycemic load diet was associated with significant gene expression changes in human prostate epithelium. These results show the feasibility of using prostate tissues collected at diagnosis and at surgery to study the effects of dietary manipulation on prostate tissue, which may give insight into the molecular mechanisms underlying the associations of diet and obesity with the development or progression of prostate cancer.