gebhart/patrepeval huggingface dataset:
Subgrid-Scale Models for Large-Eddy Simulations of Shock-Boundary-Layer Interactions (2013)

Direct numerical simulation and large-eddy simulation of a flat-plate supersonic turbulent boundary layer interacting with an oblique incident shock wave are conducted for a priori and a posteriori assessments of subgrid-scale models. The incident shock is strong enough to generate a marginal separation in the boundary layer near the interaction region providing the subgrid-scale models with a nontrivial challenge. The governing equations for direct numerical simulation and large-eddy simulation are solved by a new seventh-order monotonicity-preserving scheme for inviscid fluxes and a sixth-order compact finite-difference scheme for the viscous terms. The effect of subgrid-scale stress term on the resolved velocity field is shown to be significant and shock-dependent. The subgrid-scale models tested include the mixed-time-scale model, the dynamic Smagorinsky model, the dynamic mixed model and a new dynamic model termed the compressible serial-decomposition model. A priori analysis indicate that the new dynamic model is more accurate than other subgrid-scale closures. A posteriori tests also indicate better predictions of direct numerical simulation results by the large-eddy simulation employing the compressible serial-decomposition model.
trans-Acetonide Controlled endo-Selective Intramolecular Nitrone−Alkene Cycloaddition of Hept-6-enoses:  A Facile Entry to Calystegines, Tropanes, and Hydroxylated Aminocycloheptanes (2006)

High-yielding endo-selective intramolecular nitrone-alkene cycloaddition (INAC) reactions of hept-6-enoses controlled by a trans-acetonide to give bridged bicyclo[4.2.1]isoxazolidines exclusively are realized for the first time. The cycloadducts were readily transformed into calystegine, tropane, and hydroxylated aminocycloheptane frameworks. [reaction: see text].
Conversion from HF to H/sub 2/SO/sub 4/ alkylation (1988)

STRATCO is aware of five current grass roots customers in Japan, Italy and Kuwait who made the decision to license H/sub 2/SO/sub 4/ alkylation; part of their decision was based on the environmental risks of HF alkylation in high population densities around their refinery and future regulation of the chemical hazards of HF acid. STRATCO has also been approached by several refiners who are evaluating the risks associated with their existing HF units. Certainly there is a potential for legal liability to third parties in the event of an HF release. As a part of this risk evaluation, a natural question is: What is the feasibility of converting our alkylation unit from HF catalysts to H/sub 2/SO/sub 4/. STRATCO recently performed a series of process studies to evaluate the conversion of an HF alkylation unit to STRATCO's Effluent Refrigerated H/sub 2/SO/sub 4/ alkylation technology. The results of this work indicate that such a conversion is economically feasible and would reduce environmental and human safety risks.
Exact Timing Analysis for Asynchronous Circuits With Multiple Periods (2019)

The timing properties of asynchronous circuits can be summarized using cyclic graphs that capture max-delay constraints between signal transitions. There are many results on the timing analysis problem, but they all make various simplifying assumptions on the connectivity properties of the underlying timing graph. Most results provide approximate timing characteristics, with a few providing exact results on the circuit's timing behavior. In this article, we provide results that exactly characterize the timing properties for a more general class of max-delay constraints. We show that the circuit can be partitioned into regions with different periodicities, and provide an efficient algorithm to compute all the periods of the system.
Plasma resistant modified I-line, deep UV, and e-beam resists (1995)

This paper presents chemically modified photoresists for use as plasma etch masks over various substrates during patterning in IC manufacturing with sub-0.5 /spl mu/m resolution. The modification consists of directly adding the modifying compounds into the photoresist solutions. The added compounds increase the oxygen, fluorine, and chlorine plasma resistance of photoresists, thus promoting a high etch rate selectivity with respect to other substrates and films (e.g., polyimide, SiO/sub 2/, etc.).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A communication protocol for a multi-level secure network (2002)

An implementation of the SNet multi-level secure distributed system is described in the context of the specifications and the security model for SNet. This implementation contains a communication protocol that satisfies the specification and thereby enforces the security policy. The location of the trusted security kernel software is explicitly identified relative to the protocol layers. An informal argument is given to show how the protocol satisfies the specification and the security model.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Pentadecapeptide BPC 157 Counteracts Hemodynamic and ECG Disturbances Induced by Sotalol in Rats (2022)

Cytoprotective and organoprotective pentadecapeptide BPC 157 demonstrated particular beneficial cardiovascular effects (Curr Pharm Des. 2014;20(7):1121‐1125). Antiarrhythmic effects counteracted digoxin toxicity (Regul Pept. 2009;156(1‐3):83‐89), major blood vessel occlusions (Biomedicines 2021, 9,1029; 2021, 9,609; 2021, 9, 792) and lidocaine toxicity (Emerg Med Int. 2020;2020:6805354). Now, we reveal, by BPC 157, mitigation of hemodynamic and ECG disturbances of sotalol, a class III antiarrhythmic with non‐selective beta‐blocking activity. Albino Wistar rats received sotalol (80mg/kg, intragastrically), and at 5 min thereafter were treated with saline or BPC 157 (10ng/kg, intragastrically. Seven standard and one precordial ECG leads were recorded (baseline; after application of sotalol; and 10, 30, 90, 120 and 150 minutes after application of sotalol). Heart rate, QRS complex, PR and QT intervals were analyzed. Corrected QT intervals (QTc) were calculated according to Fridericia formula. Baseline ECG readings included average heart rate of 275.5 ± 25 bpm, average PR 54.8 ± 3.4 ms, average QRS complex 25.0 ± 4.23 ms and average QTc 166 ± 9.7 ms. Sotalol caused bradycardia (245 ± 23.5 bpm), PR prolongation (57.3 ± 2.7 ms), QRS widening (26.3 ± 3.2 ms), and QTc prolongation (173 ± 9.1 ms), measured 10 minutes after application. In BPC 157 treated animals (5 minutes after BPC‐157 application, 10 minutes after sotalol application), these effects were attenuated (heart rate 306 ± 31.7 bpm, average PR 52.3 ± 1.6 ms, average QRS 23.7 ± 5.4 ms and average QTc 159 ± 21.2 ms). This attenuation was lost in later measurements, for QRS ‐ 25 minutes after BPC 157 application, for frequency after 55 minutes, for PR after 115 minutes and for QTc after 145 minutes. In animals treated with sotalol, an increase in superior sagittal sinus pressure (10 ± 5 mmHg), as well as an increase in portal vein (17 ± 4 mmHg) and inferior caval vein pressures (12 ± 6 mmHg) were noted, along with the decrease in abdominal aortic pressure (53 ± 10 mmHg). These effects were attenuated in BPC treated animals (‐1 ± 1 mmHg for superior sagittal sinus, 7 ± 1 mmHg in portal vein, 5 ± 1 mmHg in inferior caval vein, and 81 ± 7 mmHg in abdominal aorta). In conclusion, BPC 157 attenuated deleterious hemodynamic effects of sotalol while the effects on the ECG parameters were also noted, although not long lasting, supporting the view of BPC‐157 as a rapid‐acting protective agent.
Sulfated Glycoprotein‐2 Induced Endogenous Resistance to Ischemia and Reperfusion Injury in the Seminiferous Tubules (1991)

Evidence of increased resistance of Sertoli cells to ischemia and reperfusion injury was presented by numerous histological, morphological, and quantitative studies. In situ hybridization techniques and immunocytochemical studies demonstrated intense expression of sulfated glycoprotein-2 (SGP-2) in Sertoli cells. We propose that protective effects of SGP-2 are the core of the differential tolerance of ischemia by the various testicular cells and the morphology of the postischemic testis. We believe that suppression of ischemic damage selectively in Sertoli cells is the consequence of the ability to produce SGP-2, an endogenous inhibitor of ischemic injury. This hypothetical function of SGP-2 is supported by its immunosuppressive properties and its structural and functional identity to several types of human complement cytolysis inhibitors.
Gross Variations in the Response to Man Among Yellow-Fever Mosquito Populations in the Laboratory12 (1969)

Gross differences were observed among different laboratory colonies of Aedes aegypti (L.) in their response to the human palm. The response was measured by mosquitoes landing and probing and those flying in a 1 ft3 cage over a 1-cm-diameter hole in the bottom, under which the palm was exposed. Some mosquito colonies responded very actively, others very slowly, and the difference in the mean response between the active and slow mosquito colonies was significant ( P <.05). Also, the slow mosquitoes continued to respond slowly for the following 10 days, and the active mosquitoes maintained their high activity for the same period. Therefore, the active and slow mosquito colonies constitute 2 distinct populations from the viewpoint of host-seeking behavior. Larval density in the breeding pans was examined as a possible reason for this variation. Adults obtained from larvae at 2000 per pan were compared for host-seeking activity with adults from larvae at 200 per pan (control). No significant difference in the host-seeking activity or avidity was observed between them. Therefore, crowding of the larvae was not the factor responsible for the slow response.
Fulminant demyelinating encephalomyelitis (2015)

The case with the clinical presentation of an acute demyelinating encephalomyelitis with predominant optic and spinal involvement, absent oligoclonal bands, a histopathology of acute MS pattern II and development of aquaporin-4 antibodies extends the spectrum of MOG antibody-associated encephalomyelitis. Although, MOG antibodies are suspected to indicate a favorable prognosis, fulminant disease courses are possible and warrant an aggressive immunotherapy.
Supporting scale-up of COVID-19 RT-PCR testing processes with discrete event simulation (2021)

Testing is critical to mitigating the COVID-19 pandemic, but testing capacity has fallen short of the need in the United States and elsewhere, and long wait times have impeded rapid isolation of cases. Operational challenges such as supply problems and personnel shortages have led to these bottlenecks and inhibited the scale-up of testing to needed levels. This paper uses operational simulations to facilitate rapid scale-up of testing capacity during this public health emergency. Specifically, discrete event simulation models were developed to represent the RT-PCR testing process in a large University of Maryland testing center, which retrofitted high-throughput molecular testing capacity to meet pandemic demands in a partnership with the State of Maryland. The simulation models support analyses that identify process steps which create bottlenecks, and evaluate "what-if" scenarios for process changes that could expand testing capacity. This enables virtual experimentation to understand the trade-offs associated with different interventions that increase testing capacity, allowing the identification of solutions that have high leverage at a feasible and acceptable cost. For example, using a virucidal collection medium which enables safe discarding of swabs at the point of collection removed a time-consuming "deswabbing" step (a primary bottleneck in this laboratory) and nearly doubled the testing capacity. The models are also used to estimate the impact of demand variability on laboratory performance and the minimum equipment and personnel required to meet various target capacities, assisting in scale-up for any laboratories following the same process steps. In sum, the results demonstrate that by using simulation modeling of the operations of SARS-CoV-2 RT-PCR testing, preparedness planners are able to identify high-leverage process changes to increase testing capacity.
High-Q Polymeric Microcavities (2010)

We report on the fabrication of high-Q microresonators made of poly(methyl methacrylate) (PMMA) with a conical shape due to a thermal reflow step. The cavity quality factor is above 2·106 in the 1300 nm wavelength range.
Glycosilated Macromolecular Conjugates of Antiviral Drugs with a Polyaspartamide (2004)

Two new polymeric conjugates for specific liver targeting were prepared by conjugation of sugar moieties and antiviral drugs to alpha, beta-poly[N-2-(hydroxyethyl)-DL-aspartamide] (PHEA). PHEA-galactopyranosylphenylthiocarbamide-mono-O-succinylganciclovir (conjugate 7) and PHEA-mannopyranosylphenylthiocarbamide-O-succinylacyclovir (conjugate 8) were synthesized according to a multi-step procedure which allowed for obtaining high product yield and process standardization. Conjugate 7 contained 7.5 and 8.5% of galactose and ganciclovir (substituent/repeating unit, mol/mol), respectively, and conjugate 8 contained 14.2 and 10.8% of mannose and acyclovir, respectively. In vitro studies demonstrated that both acyclovir and ganciclovir are released from the polymeric adducts at a release rate, which depended on the incubation medium. Though a detailed study evidenced that the two bioconjugates undergo different hydrolysis pathways, in both cases high drug release rate was found in plasma, while the glycosidic moiety was not released. Pharmacokinetic studies carried out by intravenous administration of the bioconjugates to Balb/c mice demonstrated that the conjugation of glycosidic moieties promotes the disappearance of the polymer from the bloodstream. The two derivatives displayed a different pharmacokinetic profile. In particular, the mannosyl conjugation promoted the rapid disposition of the macromolecule in the kidneys and in the liver, while prevented the accumulation in the spleen. On the contrary, the galactosyl derivative was found to dispose in the liver at the same extent of the naked polymer. Few considerations on the different behavior of the conjugates were reported.
False Positive and False Negative FDG-PET Scans in Various Thoracic Diseases (2006)

Fluorodeoxyglucose (FDG)-positron emission tomography (PET) is being used more and more to differentiate benign from malignant focal lesions and it has been shown to be more efficacious than conventional chest computed tomography (CT). However, FDG is not a cancer-specific agent, and false positive findings in benign diseases have been reported. Infectious diseases (mycobacterial, fungal, bacterial infection), sarcoidosis, radiation pneumonitis and post-operative surgical conditions have shown intense uptake on PET scan. On the other hand, tumors with low glycolytic activity such as adenomas, bronchioloalveolar carcinomas, carcinoid tumors, low grade lymphomas and small sized tumors have revealed false negative findings on PET scan. Furthermore, in diseases located near the physiologic uptake sites (heart, bladder, kidney, and liver), FDG-PET should be complemented with other imaging modalities to confirm results and to minimize false negative findings. Familiarity with these false positive and negative findings will help radiologists interpret PET scans more accurately and also will help to determine the significance of the findings. In this review, we illustrate false positive and negative findings of PET scan in a variety of diseases.
Direct Sparse Odometry (2016)

We propose a novel direct sparse visual odometry formulation. It combines a fully direct probabilistic model (minimizing a photometric error) with consistent, joint optimization of all model parameters, including geometry -- represented as inverse depth in a reference frame -- and camera motion. This is achieved in real time by omitting the smoothness prior used in other direct methods and instead sampling pixels evenly throughout the images. Since our method does not depend on keypoint detectors or descriptors, it can naturally sample pixels from across all image regions that have intensity gradient, including edges or smooth intensity variations on mostly white walls. The proposed model integrates a full photometric calibration, accounting for exposure time, lens vignetting, and non-linear response functions. We thoroughly evaluate our method on three different datasets comprising several hours of video. The experiments show that the presented approach significantly outperforms state-of-the-art direct and indirect methods in a variety of real-world settings, both in terms of tracking accuracy and robustness.
Rectifying Supporting Regions With Mixed and Active Supervision for Rib Fracture Recognition (2020)

Automatic rib fracture recognition from chest X-ray images is clinically important yet challenging due to weak saliency of fractures. Weakly Supervised Learning (WSL) models recognize fractures by learning from large-scale image-level labels. In WSL, Class Activation Maps (CAMs) are considered to provide spatial interpretations on classification decisions. However, the high-responding regions, namely Supporting Regions of CAMs may erroneously lock to regions irrelevant to fractures, which thereby raises concerns on the reliability of WSL models for clinical applications. Currently available Mixed Supervised Learning (MSL) models utilize object-level labels to assist fitting WSL-derived CAMs. However, as a prerequisite of MSL, the large quantity of precisely delineated labels is rarely available for rib fracture tasks. To address these problems, this paper proposes a novel MSL framework. Firstly, by embedding the adversarial classification learning into WSL frameworks, the proposed Biased Correlation Decoupling and Instance Separation Enhancing strategies guide CAMs to true fractures indirectly. The CAM guidance is insensitive to shape and size variations of object descriptions, thereby enables robust learning from bounding boxes. Secondly, to further minimize annotation cost in MSL, a CAM-based Active Learning strategy is proposed to recognize and annotate samples whose Supporting Regions cannot be confidently localized. Consequently, the quantity demand of object-level labels can be reduced without compromising the performance. Over a chest X-ray rib-fracture dataset of 10966 images, the experimental results show that our method produces rational Supporting Regions to interpret its classification decisions and outperforms competing methods at an expense of annotating 20% of the positive samples with bounding boxes.
Terpene compounds as drugs. IV. Terpenyl derivatives of local anesthetics (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTerpene compounds as drugs. IV. Terpenyl derivatives of local anestheticsAntonio Mantegani, Ernesta Marazzi-Uberti, and Ermanno ZugnaCite this: J. Med. Chem. 1968, 11, 3, 637Publication Date (Print):May 1, 1968Publication History Published online1 May 2002Published inissue 1 May 1968https://pubs.acs.org/doi/10.1021/jm00309a066https://doi.org/10.1021/jm00309a066research-articleACS PublicationsRequest reuse permissionsArticle Views53Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Narrowband MEMS resonant infrared detectors based on ultrathin perfect plasmonic absorbers (2016)

This paper reports on the demonstration of narrowband uncooled microelectromechanical resonant infrared detectors based on ultrathin perfect plasmonic absorbers. The integration of a deeply subwavelength thin (230 nm) plasmonic absorber on a piezoelectric nano plate (480 nm) enables a near perfect and narrowband absorption of mid-wavelength infrared radiation (~92% at 4.7 μm with a full width at half maximum ~800 nm) in an ultralow volume resonant thermal detector. The excellent thermal isolation (~2.4×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sup> K/W) and the high electromechanical performance of the resonant thermal detector (quality factor, Q~1527 and electromechanical coupling coefficient kt <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ~1.74%) guarantee the achievement of high sensitivity and a low noise performance, resulting in the demonstration of a high resolution (noise equivalent power ~633 pW/Hz <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">12</sup> ) narrowband infrared detectors suitable for infrared spectroscopy and multispectral imaging system.
Supplementary Tables 1-2 from Ligand-Dependent Platelet-Derived Growth Factor Receptor (PDGFR)-α Activation Sensitizes Rare Lung Cancer and Sarcoma Cells to PDGFR Kinase Inhibitors (2023)

Supplementary Tables 1-2 from Ligand-Dependent Platelet-Derived Growth Factor Receptor (PDGFR)-α Activation Sensitizes Rare Lung Cancer and Sarcoma Cells to PDGFR Kinase Inhibitors
Microwave and accelerator research (1993)

This report describes work carried out on DOE grant number DE-FG02- 92ER40731 during the period June 1, 1992 to the present. The report provides a brief summary of the program objectives, summarizes the main accomplishments and concludes with listings of conference and refereed publications.
Integrated Post-Experiment Monoisotopic Mass Refinement: An Integrated Approach to Accurately Assign Monoisotopic Precursor Masses to Tandem Mass Spectrometric Data (2010)

Accurate assignment of monoisotopic precursor masses to tandem mass spectrometric (MS/MS) data is a fundamental and critically important step for successful peptide identifications in mass spectrometry based proteomics. Here we describe an integrated approach that combines three previously reported methods of treating MS/MS data for precursor mass refinement. This combined method, “integrated post-experiment monoisotopic mass refinement” (iPE-MMR), integrates steps (1) generation of refined MS/MS data by DeconMSn; (2) additional refinement of the resultant MS/MS data by a modified version of PE-MMR; and (3) elimination of systematic errors of precursor masses using DtaRefinery. iPE-MMR is the first method that utilizes all MS information from multiple MS scans of a precursor ion including multiple charge states, in an MS scan, to determine precursor mass. With the combination of these methods, iPE-MMR increases sensitivity in peptide identification and provides increased accuracy when applied to complex high-throughput proteomics data.