gebhart/patrepeval huggingface dataset:
A self-assembled carrier-free nanosonosensitizer for photoacoustic imaging-guided synergistic chemo–sonodynamic cancer therapy (2020)

As one of the most promising noninvasive therapeutic modalities, sonodynamic therapy (SDT) can focus the ultrasound energy on tumor sites located in deep tissue and locally activate the preloaded sonosensitizer to kill tumor cells. However, exploring sonosensitizers with high SDT efficacy and desirable biosafety is still a significant challenge. Herein, we utilized the hydrophilic-hydrophobic self-assembly technology to assemble the hydrophobic organic dye Ce6 and broad spectral anti-cancer agent Paclitaxel with hydrophilic organic dye IR783 to generate a nanoscale sonosensitizer, Ce6-PTX@IR783, without the introduction of extra nanomaterials into the fabrication to guarantee high therapeutic biosafety and further potential clinical translation. The constructed nanodrug was endowed with an external ultrasound-activatable chemo-sonodynamic effect and photoacoustic imaging performance via integrating multiple moieties into one nanosystem. Ce6 could enhance the sonodynamic effect, while PTX exerted a chemotherapeutic effect, and IR783 was applied to increase tumor-specific accumulation and assist in fulfilling photoacoustic imaging. In particular, the small particle size (70 nm) of Ce6-PTX@IR783 contributed to the increased tumor accumulation via the enhanced permeability and retention effect. The high synergistically chemo-sonodynamic therapeutic efficacy has been successfully demonstrated in vitro and in vivo, in addition to the demonstrated high biodegradability, biocompatibility and biosafety. This facile self-assembly procedure provides an intriguing strategy for highly efficient utilization of hydrophobic drugs and is liable to realize large-scale production and further clinical translation.
Evaluation of Precipitation Inhibitors for Supersaturated Vanadyl Electrolytes for the Vanadium Redox Battery (1999)

As part of a project aimed at increasing the energy density of the vanadium redox battery for mobile applications, a number of additives was evaluated as precipitation inhibitors to enhance the stability of supersaturated vanadyl electrolytes in . While the saturation solubility of vanadyl sulfate in is less than at , supersaturated vanadyl sulfate solutions could readily be prepared. A blank solution of vanadyl sulfate in began to precipitate after 22 days at , reaching an equilibrium concentration of after 80 days. In the presence of or sodium hexametaphosphate, however, there was no sign of precipitation after 80 days at . ©1999 The Electrochemical Society
Delayed wound healing in aged mice is associated with diminished mobilization of circulating angiogenic cells (2010)

Zhang, Xianjie MD, PhD; Sarkar, Kakali PhD; Andrikopoulou, Efstathia MD; Xing, Dongmei MD, PhD; Liu, Lixin PhD; Reinblatt, Maura MD; Laines, Raul Sebastian MD; Marti, Guy P. MD; Semenza, Gregg L. MD, PhD; Harmon, John W. MD, FACS Author Information
Electrochemical Analysis of Conductive Polymer‐Coated LiFePO4 Nanocrystalline Cathodes with Controlled Morphology (2011)

Abstract Nanocrystalline LiFePO 4 particles and donut‐ and dumbbell‐shaped LiFePO 4 microstructures hierarchically constructed with the nanoparticles were synthesized. Coating the surfaces of the LiFePO 4 particles with conductive polymers, poly‐3,4‐ethylenedioxythiophene (PEDOT), improved battery characteristics, such as specific capacity, capacity retention, and impedances, by increasing the ionic and electric conductivities of the cathode materials as well as by enhancing the accessibility of lithium ions. The nanocrystalline LiFePO 4 that was coated with PEDOT exhibited even larger values than the theoretical value of LiFePO 4 at a rate of 1 C or lower rates were observed, with its largest specific capacities of 190 mAh g −1 and 175 mAh g −1 at the rates of 0.2 C and 1 C, respectively, due to the compatibility of the redox characteristics of LiFePO 4 and PEDOT. The cathode composed of nanocrystalline LiFePO 4 that was coated with PEDOT exhibited the lowest value of the charge transfer resistances ( R ct ) from the electrochemical impedance analysis.
Design-Based Fingerprinting Using Side-Channel Power Analysis for Protection Against IC Piracy (2018)

Intellectual property (IP) and integrated circuit (IC) piracy are of increasing concern to IP/IC providers because of the globalization of IC design flow and supply chains. Such globalization is driven by the cost associated with the design, fabrication, and testing of integrated circuits and allows avenues for piracy. To protect the designs against IC piracy, we propose a fingerprinting scheme based on side-channel power analysis and machine learning methods. The proposed method distinguishes the ICs which realize a modified netlist, yet same functionality. Our method doesn't imply any hardware overhead. We specifically focus on the ability to detect minimal design variations, as quantified by the number of logic gates changed. Accuracy of the proposed scheme is greater than 96 percent, and typically 99 percent in detecting one or more gate-level netlist changes. Additionally, the effect of temperature has been investigated as part of this work. Results depict 95.4 percent accuracy in detecting the exact number of gate changes when data and classifier use the same temperature, while training with different temperatures results in 33.6 percent accuracy. This shows the effectiveness of building temperature-dependent classifiers from simulations at known operating temperatures.
Accuracy Evaluation of Contour Next Compared with Five Blood Glucose Monitoring Systems Across a Wide Range of Blood Glucose Concentrations Occurring in a Clinical Research Setting (2014)

When compared with other BGMSs, CN demonstrated the lowest mean deviation from the reference value (by MAD and MARD) across multiple glucose ranges.
Optimal timing of influenza vaccination during 3‐week cytotoxic chemotherapy cycles (2016)

The antibody responses to influenza vaccination on days 1 and 11 during a 3-week cytotoxic chemotherapy cycle were comparable. Influenza vaccination can be performed concurrently with cytotoxic chemotherapy or during the cytopenic period. Cancer 2017;123:841-48. © 2016 American Cancer Society.
Discovery of the Philadelphia chromosome: a personal perspective (2007)

Almost 50 years ago, David Hungerford and I noticed an abnormally small chromosome in cells from patients with chronic myelogenous leukemia (CML). This article is a personal perspective of the events leading to the discovery of this chromosome, which became known as the Philadelphia chromosome. As technology advanced over subsequent decades, the translocation resulting in the Philadelphia chromosome has been identified, its role in the development of CML has been confirmed, and a therapy directed against the abnormal protein it produces has shown promising results in the treatment of patients with CML.
Experimental Peracute Colibacillosis: Gastrointestinal Lesions in Gnotobiotic Piglets (1972)

Three-day-old, hysterectomy-derived germ-free piglets were challenged with an enteropathogenic strain of Escherichia coli. This particular strain (serotype 08:K87, K88ac:H19) was highly pathogenic and produced clinical signs of enteric colibacillosis. The major lesions consisted of marked gastric dilation and extensive congestion involving the greater curvature of the fundus. The gastrointestinal lesions were considered to be the direct result of the active infection by this strain. No similar condition was observed in similar experiments with 16 other E. coli serotypes in neonatal germ-free swine.
Electrochemical Oxidation of Ethanol Using Heterobimetallic Complexes as an Approach to DEFC Catalysts (2009)

Direct ethanol fuel cells (DEFCs) are an attractive alternative to their methanol analogues. A series of Ru/Pt, Ru/Pd and Ru/Au complexes was studied to determine the electrocatalytic activity of these complexes for the oxidation of ethanol. Cyclic voltammetry was performed to establish the affinity of these complexes towards ethanol oxidation. Constant potential (bulk) electrolysis was carried out and the liquid products of oxidation were identified and quantified by gas chromatography. Headspace gas samples were collected in a modified airfree cell and analyzed using a Fourier transform infrared spectrometer.
Microdialysis: is it ready for prime time? (2009)

Cerebral microdialysis is an established tool for neurochemical research in the ICU. This technique cannot be fruitfully used in isolation, but when combined with other monitoring methods provides unique insights into the biochemical and physiological derangements in the injured brain.
MuCAN: Multi-Correspondence Aggregation Network for Video Super-Resolution (2020)

Video super-resolution (VSR) aims to utilize multiple low-resolution frames to generate a high-resolution prediction for each frame. In this process, inter- and intra-frames are the key sources for exploiting temporal and spatial information. However, there are a couple of limitations for existing VSR methods. First, optical flow is often used to establish temporal correspondence. But flow estimation itself is error-prone and affects recovery results. Second, similar patterns existing in natural images are rarely exploited for the VSR task. Motivated by these findings, we propose a temporal multi-correspondence aggregation strategy to leverage similar patches across frames, and a cross-scale nonlocal-correspondence aggregation scheme to explore self-similarity of images across scales. Based on these two new modules, we build an effective multi-correspondence aggregation network (MuCAN) for VSR. Our method achieves state-of-the-art results on multiple benchmark datasets. Extensive experiments justify the effectiveness of our method.
Reflexión pragmático-trascendental: la perspectiva principal de una transformación Kantiana actual (2004)

In this paper, the Author discusses an attempt to transform transcendental philosophy as a hermeneutic\ntransformation. It should account for not only knowledge validity requirements and moral\nstandards but also the world's sense of being which is historically conditioned. This transformation\nmight stem from Kantian reflection or, rather from beyond the reflection itself, via the core role of\nlanguage that is absent in Kant. Apel resorts to this in an attempt to achieve a pragmatic-trascendental\njustification of Ethics with due recognition that, thanks to its situational character, it should allow\na most responsible enforcement.
The Plasmodium falciparum Translationally Controlled Tumor Protein Homolog and Its Reaction with the Antimalarial Drug Artemisinin (1998)

Artemisinin and its derivatives are important new antimalarial drugs. When Plasmodium falciparum-infected erythrocytes are incubated with [10-3H]dihydroartemisinin, several malaria-specific proteins become labeled. One of these proteins is the P. falciparum translationally controlled tumor protein (TCTP) homolog. In vitro, dihydroartemisinin reacts covalently with recombinant TCTP in the presence of hemin. The association between drug and protein increases with increasing drug concentration, plateauing at approximately 1 drug/TCTP molecule. By Scatchard analysis, there appear to be 2 hemin binding sites on TCTP with dissociation constants of approximately 18 microM. When the single cysteine moiety is blocked by pretreatment with iodoacetamide, hemin binding is not affected, whereas drug binding is reduced by two-thirds. Thus, TCTP reacts with artemisinin in situ and in vitro in the presence of hemin and appears to bind to hemin. The function of the malarial TCTP and the role of this reaction in the mechanism of action of artemisinin await elucidation.
Whole transcriptome expression array analysis of human colon fibroblasts culture treated with Helichrysum italicum supports its use in traditional medicine (2022)

With the careful evaluation of the role of individual genes, especially SERPING1, ARHGAP1, IL33 and CDKN1A, represented in the enriched pathways and processes, we propose the main mode of HI action, which is wound healing. In addition to its indirect prevention of diseases resulting from the impaired barrier integrity, HI also effects inflammation and metabolic processes directly, as it regulates genes such as LRPPRC, LIPA, ABCA12, PRKAR1A and ANXA6.
Actin Assembly around the Shigella-Containing Vacuole Promotes Successful Infection (2020)

The enteroinvasive bacterium Shigella flexneri forces its uptake into non-phagocytic host cells through the translocation of T3SS effectors that subvert the actin cytoskeleton. Here, we report de novo actin polymerization after cellular entry around the bacterium-containing vacuole (BCV) leading to the formation of a dynamic actin cocoon. This cocoon is thicker than any described cellular actin structure and functions as a gatekeeper for the cytosolic access of the pathogen. Host CDC42, TOCA-1, N-WASP, WIP, the Arp2/3 complex, cortactin, coronin, and cofilin are recruited to the actin cocoon. They are subverted by T3SS effectors, such as IpgD, IpgB1, and IcsB. IcsB immobilizes components of the actin polymerization machinery at the BCV dependent on its fatty acyltransferase activity. This represents a unique microbial subversion strategy through localized entrapment of host actin regulators causing massive actin assembly. We propose that the cocoon promotes subsequent invasion steps for successful Shigella infection.
Antinociceptive action of limonexic acid obtained fromRaulinoa echinata (2007)

The antinociceptive effect of the limonexic acid isolate of Raulinoa echinata Cowan in four models of pain in mice is described. When evaluated against acetic acid-induced abdominal constrictions, limonexic acid (10, 30 and 60 mg kg(-1), i.p.) produced dose-related inhibition of the number of constrictions, with a mean ID50 value of 43 (2.3-79) micromol kg(-1), and was more potent than some standard drugs. In the formalin test, limonexic acid inhibited both the first and second phases of formalin-induced pain. Furthermore, the effect was more pronounced in the second phase, with a mean ID50 value of 13.66 (9.35-19.61) micromol kg(-1), and had a pharmacological profile that was similar to standard drugs such as acetaminophen and acetyl salicylic acid. Limonexic acid also produced dose-related inhibition of glutamate- and capsaicin-induced pain, with mean ID50 values of 11.67 (8.51-16.0) micromol kg(-1) and 47.17 (36.51-60.93) micromol kg(-1), respectively. The mechanism of action is not completely understood, but seems to involve direct interaction with the GABAergic and nitroxidergic pathways.
Normas y estándares en el entorno de la IDEE (2004)

RESUMEN El objetivo de este articulo es la exposicion del conjunto de normas y estandares que estan relacionados directamente con la creacion de la Infraestructura de Datos Espaciales de Espana (IDEE). Para ello sera necesario conocer las distintas asociaciones y organizaciones, tanto a nivel nacional como internacional, involucradas en el desarrollo y publicacion de estandares, las relaciones entre ellas y su implicacion en la IDEE. Por ultimo, se profundiza en las especificaciones de los estandares claves en la construccion de una IDE.
Characterization of the relaxant action of urocortin, a new peptide related to corticotropin‐releasing factor in the rat isolated basilar artery (1998)

In addition to its well established neuroendocrine and neurotransmitter effects, corticotropin releasing factor (CRF) exerts a potent vasorelaxant action. Recently, a CRF-related peptide, urocortin, has been identified in the mammalian brain. In the present study, the cerebral vasomotor action of this peptide and the mechanism underlying its relaxant effect are characterized. Ring segments obtained from the rat basilar artery were used for measurement of isometric force. The relaxant action of urocortin, CRF and sauvagine was studied in segments with a functionally intact endothelium. In segments precontracted with prostaglandin F2alpha, urocortin, CRF and sauvagine induced concentration-related relaxation. The order of potency was as follows (pD2+/-s.e.m. given in brackets): urocortin (9.32+/-0.07) > sauvagine (9.08+/-0.08) > CRF (7.50+/-0.07). Complete relaxation was achieved with each agonist. Relaxation was not affected by removal of the endothelium but was markedly attenuated in segments precontracted with 50 mM K+ Krebs solution. The relaxant effect of urocortin was inhibited by astressin in an apparently competitive manner. A pA2 value of 7.52 was estimated for astressin. Inhibition of urocortin-induced relaxation was also observed in the presence of the adenylate cyclase inhibitor SQ22536 (pD2 in the presence of 300 microM SQ22536, 9.36+/-0.05) and the K+ channel blockers tetraethylammonium (10 mM; pD2, 8.65+/-0.07), iberiotoxin (100 nM; pD2, 8.88+/-0.08) and apamin (10 nM; pD2, 8.94+/-0.07). However, the inhibitory actions of SQ22536 and apamin or iberiotoxin were not additive. The results suggest that urocortin induces relaxation of cerebral arteries by activating CRF-R2 receptors present in the vascular wall. Relaxation appears to be mediated by adenylate cyclase stimulation and activation of Ca2+-dependent K+ channels.
<title>Motion estimation for coding of moving video at 8 kbit/s with Gibbs-modeled vectorfield smoothing</title> (1990)

A new approach to motion-estimation for hybrid image sequence coding is presented. Instead of minimizing the displaced frame difference (DFD), the estimator introduced in this paper maximizes the probability to determine the ’true’ physical motion of the scene. The probability expression is derived from two models, one for the statistics of the prediction error image and one for the interdependency of vectors in a vectorfield. The physical vectorfield is smoother than the vectorfield of a DFD-estimator and stronger statistical bindings between vectors exist. Therefore a coding algorithm for the vectorfield combining contour coding of regions of similar displacement with predictive coding of the vectors inside each region proves efficient. This allows the estimator to work with decreased blocksize and (even in DFD sense) to supply a distinctly improved displacement-compensation without spending more datarate for displacement-compensation than the DFD- estimator.
Five Confirmed Human Cases of Gnathostomiasis Nipponica Recently Found in Northern Japan (1992)

Five confirmed human cases of gnathostomiasis nipponica exhibiting creeping eruption and itching were found sporadically from the autumn of 1991 to the winter of 1992 in the northern region of the mainland of Japan. In all cases, a causative gnathostome with 3 transverse rows of hooklets on the head bulb was detected in biopsied skin. The morphological characteristics agreed with the advanced third-stage larvae of Gnathostoma nipponicum. Within a few weeks before development of symptoms, all patients had histories of eating raw freshwater fishes, kokanee (Salmo nerka nerka), carp (Cyprinus carpio), crucian carp (Carassius gibelio langsdorfi), or common ice-fish (Salangichthys microdon). However, they had never eaten raw loach, which is known as a source of human infections with G. nipponicum.
The specialized proresolving lipid mediator maresin 1 protects hepatocytes from lipotoxic and hypoxia‐induced endoplasmic reticulum stress (2017)

Endoplasmic reticulum (ER) stress and activation of the unfolded protein response (UPR) are hallmarks of nonalcoholic fatty liver disease (NAFLD), which is the hepatic manifestation of the metabolic syndrome associated with obesity. The specialized proresolving lipid mediator maresin 1 (MaR1) preserves tissue homeostasis by exerting cytoprotective actions, dampening inflammation, and expediting its timely resolution. Here, we explored whether MaR1 protects liver cells from lipotoxic and hypoxia-induced ER stress. Mice were rendered obese by high-fat diet feeding, and experiments were performed in primary hepatocytes, Kupffer cells, and precision-cut liver slices (PCLSs). Palmitate-induced lipotoxicity increased ER stress and altered autophagy in hepatocytes, effects that were prevented by MaR1. MaR1 protected hepatocytes against lipotoxicity-induced apoptosis by activating the UPR prosurvival mechanisms and preventing the excessive up-regulation of proapoptotic pathways. Protective MaR1 effects were also seen in hepatocytes challenged with hypoxia and TNF-α-induced cell death. High-throughput microRNA (miRNA) sequencing revealed that MaR1 actions were associated with specific miRNA signatures targeting both protein folding and apoptosis. MaR1 also prevented lipotoxic-triggered ER stress and hypoxia-induced inflammation in PCLSs and enhanced Kupffer cell phagocytic capacity. Together, these findings describe the ability of MaR1 to oppose ER stress in liver cells under conditions frequently encountered in NAFLD.-Rius, B., Duran-Güell, M., Flores-Costa, R., López-Vicario, C., Lopategi, A., Alcaraz-Quiles, J., Casulleras, M., Lozano, J. J., Titos, E., Clària, J. The specialized proresolving lipid mediator maresin 1 protects hepatocytes from lipotoxic and hypoxia-induced endoplasmic reticulum stress.
Identification of Newly Emerging Influenza Viruses by Surface-Enhanced Raman Spectroscopy (2015)

In this work, we demonstrate in situ virus identification based on surface-enhanced Raman scattering (SERS). We hypothesized that newly emerging influenza viruses possess surface proteins and lipids that can generate distinctive Raman signals. To test this hypothesis, SERS signals were measured from the surface of a noninfluenza virus, two different influenza viruses, and a genetically shuffled influenza virus. To ensure the safety for experimenters we constructed nonreplicating pseudotyped viruses that display main influenza virus surface components. Pseudotype with influenza virus components produced enhanced Raman peaks, on gold nanoparticles, that are easily distinguishable from those of pseudotype with a noninfluenza virus component, vesicular stomatitis virus G protein (VSVG). Furthermore, virus with the surface components of a newly emerging influenza strain, A/California/04/2009 (H1N1), generated Raman peaks different from those of viruses with components of the conventional laboratory-adapted influenza strain, A/WSN/33 (H1N1). Interestingly, the virus simultaneously displaying surface components of both influenza strains, a model mutant with genome reassortment, also produced a Raman signal pattern that is clearly distinguishable from those of each strain. This work highlights that SERS can provide a powerful label-free strategy to quickly identify newly emerging and potentially fatal influenza viruses.
COVID-19 vaccines and pregnancy (literature review) (2021)

<h3></h3> В данном обзоре литературы представлена актуальная на сегодняшний день информация об эффективности и безопасности вакцин против новой коронавирусной инфекции COVID-19 при беременности и грудном вскармливании. Рассмотрены типы зарегистрированных вакцин против COVID-19 и имеющиеся данные об их репродуктивной токсичности. В обзоре отражены клинические рекомендации международных профессиональных сообществ относительно вакцинации беременных, включая Всемирную организацию здравоохранения, RCOG (Королевский колледж акушеров и гинекологов Великобритании), ACOG (Американский колледж акушеров и гинекологов), RANZCOG (Королевский Австралийский и Новозеландский колледж акушеров и гинекологов).
Editorial: Developmental origin of diseases: a special focus on the parental contribution towards offspring’s adult health (2023)

EDITORIAL article Front. Endocrinol., 15 May 2023Sec. Pediatric Endocrinology Volume 14 - 2023 | https://doi.org/10.3389/fendo.2023.1196653