gebhart/patrepeval huggingface dataset:
Depletion-activated calcium current is inhibited by protein kinase in RBL-2H3 cells. (1995)

Whole-cell patch-clamp recordings and single-cell Ca2+ measurements were used to study the control of Ca2+ entry through the Ca2+ release-activated Ca2+ influx pathway (ICRAC) in rat basophilic leukemia cells. When intracellular inositol 1,4,5-trisphosphate (InsP3)-sensitive stores were depleted by dialyzing cells with high concentrations of InsP3, ICRAC inactivated only slightly in the absence of ATP. Inclusion of ATP accelerated inactivation 2-fold. The inactivation was increased further by the ATP analogue adenosine 5'-[gamma-thio]triphosphate, which is readily used by protein kinases, but not by 5'-adenylyl imidodiphosphate, another ATP analogue that is not used by kinases. Neither cyclic nucleotides nor inhibition of calmodulin or tyrosine kinase prevented the inactivation. Staurosporine and bisindolylmaleimide, protein kinase C inhibitors, reduced inactivation of ICRAC, whereas phorbol ester accelerated inactivation of the current. These results demonstrate that a protein kinase-mediated phosphorylation, probably through protein kinase C, inactivates ICRAC. Activation of the adenosine receptor (A3 type) in RBL cells did not evoke much Ca2+ influx or systematic activation of ICRAC. After protein kinase C was blocked, however, large ICRAC was observed in all cells and this was accompanied by large Ca2+ influx. The ability of a receptor to evoke Ca2+ entry is determined, at least in part, by protein kinase C. Antigen stimulation, which triggers secretion through a process that requires Ca2+ influx, activated ICRAC. The regulation of ICRAC by protein kinase will therefore have important consequences on cell functioning.
The charge state of C60(buckminsterfullerene) molecules adsorbed on a metal surface: theoretical considerations (1992)

The charge state of a C60 molecule is strongly dependent on its environment. We discuss the factors that determine the charge state of C60 molecules adsorbed on metal substrates. An estimate of the charge state of a C60 molecule adsorbed without covalent bonding on a smooth simple metal surface is calculated taking into account the Coulomb interaction of the C60−n ion with its image charge and the polarization of the molecule, assuming the metal to be a perfect conductor, and the van der Waals interaction, using a Lennard-Jones pairwise potential based on graphite. We find that at most two electrons can be transferred to the molecule regardless of the work function of the metal. The broadening of the LUMO level of the adsorbed molecule due to resonance with the substrate energy levels will allow for a partial charge transfer even for metal substrates with work functions as high as 4.5 eV.
LONG-TERM CARDIOVASCULAR SAFETY OF CRYSTALLINE GLUCOSAMINE SULFATE: A RETROSPECTIVE ANALYSIS OF TWO RANDOMIZED CONTROLLED TRIALS (2011)

Palma Dos Reis, R.; Bonazzi, A.; André, R; Giacovelli, G.; Rovati, L. Author Information
Hardware-In-the-Loop Simulator with Auto Building Vehicle Model for Adaptive Cruise Control System (2004)

&lt;div class="htmlview paragraph"&gt;A Hardware-In-the-Loop simulator with a vehicle-ready Electronic Control Unit (ECU) coupled with a vehicle model, simulating a real vehicle movement in real time, was developed. The simulator was used to validate the ECU software and hardware components of the Adaptive Cruise Control (ACC) system.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;The authors have modularized each vehicle component so that the entire vehicle model can be rebuilt automatically by selecting each component. This feature enables flexible and rapid building of the virtual vehicle. As a result, the simulator with auto building vehicle model allowed the development and validation of the ACC control system for various vehicle configurations.&lt;/div&gt;
Rh hemolytic disease of the newborn: using incidence observations to evaluate the use of RH immune globulin. (1981)

During the 1970s, the crude incidence of Rh hemolytic disease of the newborn (RhHDN) in the United States dropped 65 per cent---from 40.5/10,000 total births in 1970 to 14.3/10,000 total births in 1979. Since the risk of RhHDN is directly associated with birth order, changes both in birth order-specific RhHDN incidence rates and in the birth order distribution would be expected to influence crude RhHDN incidence. Review of birth order-specific incidences ascertained in Connecticut, 1972-1977, shows that incidence was stable for first and second births, whereas it dropped significantly for third and fourth births. Due to the nearly complete use of Rh immune globulin (RhIG) in Connecticut during these years, the drop in these specific rates is best attributed to this prevention strategy. Nationwide, during the 1970s, the annual percentages of fourth and higher order births decreased from 18 per cent to 10 per cent. We estimate that some 30 per cent to 40 per cent of the 1970-1979 drop in the crude rate is attributed to changes in the birth order distribution, whereas 60 per cent to 70 per cent of the drop is attributed to RhIG. However, comparison of pooled incidences for 1972-1974 and 1975-1977 observed in Connecticut for first births and births to 15-19 year olds showed significant increases for both groups in 1975-1977. Further study of specific trends from other areas is needed to confirm these observations. Also needed is investigation of likely causes of sensitization among these teenaged, primiparous women.
A robust LMS-based Fourier analyzer capable of accommodating the frequency mismatch (2004)

The conventional LMS Fourier analyzer has been successfully used to analyze sinusoidal and periodic signals in additive noise. If the user provides the correct signal frequencies, the analyzer produces good estimates for the discrete Fourier coefficients (DFCs) of the signal. However, if the signal frequencies fed to the analyzer vary from the true signal frequencies, i.e., a frequency mismatch (FM) exists, the performance of the conventional LMS algorithm degenerates. We propose a new LMS-based Fourier analyzer that yields superior results to the conventional LMS one. The estimation of DFCs and the reduction of FM in the new algorithm are carried out simultaneously based on the least mean square and the least mean p-power error criteria, respectively. This new algorithm has a simple structure and shows a small increase in computations. Simulations as well as a real-life application to real signals generated by a large-scale factory cutting machine are provided to show the effectiveness of our new algorithm. For the latter, the performance improvement is as high as 8.3 [dB].
Boosting of the Performance of Perovskite Solar Cells through Systematic Introduction of Reduced Graphene Oxide in TiO2 Layers (2015)

Abstract The effects of the inclusion of reduced graphene oxide (RGO) in TiO2 layers on performance of perovskite solar cells were systematically investigated. For this purpose, a wet chemical approach was examined to embed graphene oxide (GO) across the thickness of compact TiO2 (cTiO2) and mesoporous TiO2 (mTiO2) layers, which was followed by a thermally driven in situ conversion from GO to RGO. The presence of RGO at loadings of 0.15 wt % in the cTiO2 layer and of 0.015 wt % in the mTiO2 layer led to a power conversion efficiency (PCE) from 6.6% to 9.3% by 40% increase.
A radiographic-based method for marginal bone loss measurement in dental implants (2013)

Radiographic assessment of marginal bone loss is one of the most used criteria in longitudinal control of dental implant osseointegration. Accurate and reproducible results are difficult to obtain, due to considerable intra- and interoperator variability. In this work a semi-automatic approach to establish the degree of osseointegration of dental implants based on radiographic images is presented. The marginal bone loss around 47 implants in 16 patients were assessed. Computer-assisted results were compared with those provided manually by three expert graders. The method provides a mean inter-variability reduced of the 70% with respect to the manual measures. Limiting the analysis to the subset of implants characterized by a manual inter-variability lower than 25%, the automatic results are well correlated with the manual measures: estimating the marginal bone loss, the value of R <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ranges from 0.62 to 0.86; estimating the screws' axis length, the value of R <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> is always above 0.99.
Facile synthesis of a continuous thin Cu(bipy)2(SiF6) membrane with selectivity towards hydrogen (2013)

Cu(bipy)2(SiF6) is a highly porous metal–organic framework (MOF) and represents a prototypal “pillared sheet” platform offering opportunities to control the pore sizes. Its structural features, low cost and facile synthesis make it a great candidate to fabricate membranes for gas separation. The key to obtaining thin, continuous Cu(bipy)2(SiF6) membranes is to control the Cu(bipy)2(SiF6) crystal growth and enhance the binding between membrane and substrate. Here we explored a new route by direct synthesis and successfully obtained a continuous thin Cu(bipy)2(SiF6) membrane on a macroporous glass-frit disk with high robustness. It is speculated that the SiF62− used to construct the Cu(bipy)2(SiF6) membrane came from the fluorinated substrate. The Cu(bipy)2(SiF6) membrane shows the separation factors of H2–CO2, H2–CH4 and H2–N2 are 8.0, 7.5, and 6.8 respectively at 293 K and 1 bar with H2 permeance of 2.7 × 10−7 mol m−2 s−1 Pa−1 as well as high thermal stability. We expect to explore more membranes of Cu(bipy)2(SiF6) analogues with tuneable pore sizes using this route and to obtain membranes with higher gas separation performance.
Tear and serum antibody response to Chlamydia trachomatis antigens during acute chlamydial conjunctivitis in monkeys as determined by immunoblotting (1987)

In this study, we examined the temporal antibody response by immunoblotting analysis in tears and sera of three cynomolgus monkeys (Macaca fasicularis) with primary acute Chlamydia trachomatis serovar B conjunctivitis. The objective was to identify chlamydial antigens stimulating antibody during the host responses in the course of this self-limiting infection with the rationale that they may be protective antigens. The major outer membrane protein (MOMP), lipopolysaccharide (LPS), and polypeptides of 60 and 68 kilodaltons (kDa) were the predominant antigens recognized by immunoglobulin A (IgA) in monkey tears. Tear IgA antibody specific for the MOMP was first detected 14 days postinfection, whereas tear IgA reactive with LPS or the 68- and 60-kDa polypeptides was first detectable on day 21. Tear IgA antibodies specific for each of these antigens persisted in tears through day 56, 4 weeks after both peak clinical disease and recovery of the organism from the conjunctivae. In contrast, tear IgG antibodies peaked at approximately 28 days postinfection, the time of maximal inflammatory response. The IgG response in monkey sera was similar to that observed for tear antibodies, in that the MOMP, 60-, and 68-kDa polypeptides were the primary immunogens. The exception was that IgG antibody against these antigens was detected 1 week later than that observed for tear IgA antibodies. Of three monkeys that responded with tear IgA antibody against LPS, one did not have detectable serum IgG LPS antibody. The specificity of the tear IgA antibody response of monkeys was determined by immunoblotting nine other C. trachomatis serovars in addition to the homologous B serovar. The tear IgA response to the MOMP was predominantly B complex subspecies-specific (serovars B, Ba, D, and E), whereas the response to chlamydial LPS was found to be species-specific. The significance of these observations in relation to previous vaccine studies in nonhuman primates is discussed.
Generation of strong casein kinase 1 inhibitor of Arabidopsis thaliana (2019)

Abstract Casein kinase 1 (CK1) is an evolutionarily conserved protein kinase among eukaryotes. Studies on yeast, fungi, and animals have revealed that CK1 plays roles in divergent biological processes. By contrast, the collective knowledge regarding the biological roles of plant CK1 lags was behind those of animal CK1. One of reasons for this is that plants have more multiple genes encoding CK1 than animals. To accelerate the research for plant CK1, a strong CK1 inhibitor that efficiently inhibits multiple members of CK1 proteins in vivo (in planta) is required. Here, we report a novel strong CK1 inhibitor of Arabidopsis (AMI-331). Using a circadian period-lengthening activity as estimation of the CK1 inhibitor effect in vivo, we performed a structure-activity relationship (SAR) study of PHA767491 (1,5,6,7-tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one hydrochloride), a potent CK1 inhibitor of Arabidopsis, and found that PHA767491 analogues bearing a propargyl group at the pyrrole nitrogen atom (AMI-212) or a bromine atom at the pyrrole C3 position (AMI-23) enhance the period-lengthening activity. The period lengthening activity of a hybrid molecule of AMI-212 and AMI-23 (AMI-331) is about 100-fold stronger than that of PHA767491. An in vitro assay indicated a strong inhibitory activity of CK1 kinase by AMI-331. Also, affinity proteomics using an AMI-331 probe showed that targets of AMI-331 are mostly CK1 proteins. As such, AMI-331 is a strong potent CK1 inhibitor that shows promise in the research of CK1 in plants.
ChemInform Abstract: A Novel 1,3 O → C Silyl Rearrangement in Carbohydrate Chemistry: Synthesis of α‐D‐Glycopyranosyltrimethylsilanes. (1990)

Abstract Only the pyranosides (I) and (IV) undergo the title rearrangement to give the products (II) and (V), respectively.
Dislocation and antiphase domain free microscale GaAs crystals grown on SiO2 from (001) Si nano-areas (2013)

The epitaxial lateral overgrowth of microscale GaAs crystals on a 0.6 nm thick SiO2 layer from nanoscale Si seeds is investigated in order to develop GaAs monolithic hetero-epitaxy onto (001) Si. The nucleation from small width openings enables to avoid the emission of misfit dislocations and the formation of antiphase domains. Consequently, the interface between the GaAs island and the SiO2 layer remains perfectly sharp and free of defects. The only defects found by transmission electron microscopy in each island are pairs of twins, and a simple model based on the anisotropy of zinc blende crystal is proposed to explain their formation. Micro-photoluminescence measurements performed at room temperature show that these twins are not detrimental for the quality of microscale GaAs crystals.
Enhanced Glucose Sensor Linearity Using Poly(Vinyl Alcohol) Hydrogels (2009)

Enhancement in the performance of a PVA-coated sensor is attributed to the oxygen-storing capability of PVA hydrogel due to the formation of hydrophobic domains during its freezing and thawing employed to physical cross-link the PVA. Such membranes with the capability to release TRMs continuously while storing oxygen constitute a major improvement over current outer membrane technologies.
Risk factors for multicentric occurrence of carcinoma in the upper aerodigestive tract—analysis with a serial histologic evaluation of the whole resected‐esophagus including carcinoma (2003)

These findings strongly support the hypothesis that heavy smoking and heavy drinking, as well as a family history of both UADT and lung cancer, might be risk factors for multicentric occurrence of UADT cancer.
Performance Analysis of Dual 5 GHz WiFi and UHF TV White Space Network Links (2019)

Commonly used WiFi is known to be ill-suited for penetrating vegetation and buildings and non-line-of-sight conditions. Television white space (TVWS) operates in ultra-high frequency (UHF) bands that overcome many of the penetration and line-of-sight challenges found in the 2.4 GHz and 5 GHz bands normally used by WiFi. The aim of this study is to report on the performance of WiFi technology in the 5 GHz band and the TVWS technology in the 600 MHz UHF TV band as well as a combination of both radios in two different scenarios, short-range clear line-of-sight, and non-line-of-sight conditions. A number of performance metrics, such as estimated throughput, bitrate, signal strength, noise, transmit power, transmit error, packet loss, and round trip time, are compared for varied distances and increasing levels of vegetation in the propagation path. Both TVWS and WiFi experiments showed increased sensitivity to noise as channel widths increased with TVWS being particularly susceptible to noise in nearby channels from powerful TV transmitters. Aggregating the WiFi and TVWS radios proved to have the best performance improvements when the WiFi and TVWS links had similar throughput in line-of-sight conditions.
Quantum throughput: Estimating the quantumness of optical devices using homodyne measurements (2011)

New quantum optical devices such as quantum repeaters, quantum memories, and quantum channels are important components in quantum communication technologies. We outline a method for characterizing such devices via their capacity to preserve entanglement, or quantum throughput. Using minimal experimental resources, we can quantify the entanglement which remains in a test state after interaction with an optical device. Our method provides good estimates in the low‐noise regime.
Amino-grafted graphene as a stable and metal-free solid basic catalyst (2012)

Metal-free catalysts are essential for various chemical reactions in industrial chemistry. Amino-functionalized carbon is a cheap and environmentally friendly solid basic catalyst. Here, NEt3-graphene solid basic catalyst has been synthesized through a consecutive deprotonation/carbometalation and electrophilic substituent. Transmission electron microscopy (TEM), scanning electron microscopy (SEM), elemental analyses, thermal analyses, Raman spectroscopy, and X-ray photoelectron spectroscopy (XPS) studies confirmed the formation of the target structure. Catalytic hydrolysis of ethyl acetate reveals that the amino-grafted graphene has a high catalytic activity.
Experimental Bile Duct Hyperplasia in Ducklings (1967)

INTRODUCTION THE biological effects of aflatoxins, the toxic factors isolated from groundnuts contaminated with some strains of Aspergillus flavus, have been described extensively (Wogan, 1965). Asplin and Carnaghan (1961) showed that day-old ducklings are highly susceptible to aflatoxins; they found that these animals are eminently suitable for screening suspected samples of groundnut meal and for other experimental work connected with this type of toxin: aflatoxins caused extensive bile duct proliferation in ducklings, even within a few days. Newberne et al. (1964b) stated that aflatoxin B1, the major toxic metabolite, administered in 5 daily doses of 0.4 μg., initiated clearly defined bile duct hyperplasia. The extent of this hyperplasia appeared to be related to the dose of aflatoxin (Chang et al., 1963). Various investigators have demonstrated that aflatoxin-containing diets led to the development of liver tumours in rats (Lancaster et al., 1961; Le Breton et al., 1962; Newberne et al., 1964a), . . .
High-efficiency multipass Ti:sapphire amplifiers for a continuous-wave single-mode laser (1991)

We present the amplification of a continuous-wave single-mode ring dye laser in Ti:sapphire. A peak gain of 2 x 10(6) has been obtained in a passive multipass amplifier, which yielded 20-nsec pulses of 0.7-mJ energy at 780 nm. We discuss the advantages of this passive multipass amplifier in comparison with a regenerative amplifier that we have also developed. By second-harmonic generation we obtained high-peak-power UV pulses from the amplified single-mode laser.
A Test Bench Concept and Method for Image-Based Modeling of Geometric Wire Bending Behavior in Needle Winding Processes (2022)

The needle winding technology offers the potential to produce high-quality windings for electrical machines. However, realizing this potential requires detailed process knowledge, especially of wire behavior. Therefore, this paper describes the first steps toward detailed data-driven modeling of geometric wire behavior in needle winding processes. We develop a purpose-built test bench that can replicate arbitrary wire bending geometries occurring during regular needle winding. By constraining the wire deformations to a two-dimensional plane, the setup allows the resulting wire shapes, which are otherwise difficult to model and capture, to be recorded with a camera. From the resulting images, a dedicated image processing pipeline extracts detailed spline models of wire bending geometry. Thus, datasets can be recorded which assign the essential influencing factors to mathematical models of the wire bending geometry. Analyses of resulting model behavior show accurate approximation results and confirm the suitability of the developed test bench concept and image processing method for capturing and evaluating wire bending geometries. Thus, this work lays the foundation for an efficient data-driven model of wire bending geometry as a function of wire tensile force and wire exit angles at the needle outlet.
Campylobacter pylori: Swedish Experiences (1989)

All patients referred for gastroscopy were investigated by Campylobacter pylori culture and antibody titration. An enzyme immunoassay was developed and found to have a negative predictive value of 0.997, which indicates that serologic tests could be used for screening of patients before gastroscopy. A close correlation was found between active and inactive duodenal and gastric ulcer and positive C. pylori culture. Small open treatment trials with the antibiotics doxycycline, tinidazole, amoxycillin, and norfloxacin were ineffective for the eradication of C. pylori. Treatment with the new anti-ulcer agents enprostil, rioprostil, and omeprazole had no effect on the presence of C. pylori.
Improving data collection, documentation, and workflow in a dementia screening study (2017)

NLM informationist supplements provide librarians with valuable experience in collaborating with study teams to address their data needs. For this project, the librarians gained skills in project management, REDCap, and understanding of the challenges and specifics of a clinical research study. However, the time and effort required to provide targeted and intensive support for one study team was not scalable to the library's broader user community.
Research design and statistical analysis (2011)

Preliminary Considerations Samples and Populations Some Important Distributions Between-Subjects Designs - One Factor Between-Subjects Designs - Several Factors Contrasts Among Means Trend Analysis Repeated-Measures Designs Mixed Designs - Combining Between-Subject and Within-Subjects Factors Hierarchical Designs Latin Squares and Related Designs Bivariate Correlation and Regression Analysis of Covariance More About Correlation Multiple Regression Regression with Categorical Variables Appendices - Notation and Summation Operations, Expected Values and Their Applications, Matrix Algebra, Statistical Tables, Control Information for Computer Programmes for Statistical Analysis.