gebhart/patrepeval huggingface dataset:
Dual Deletion of the Sirtuins SIRT2 and SIRT3 Impacts on Metabolism and Inflammatory Responses of Macrophages and Protects From Endotoxemia (2019)

Sirtuin 2 (SIRT2) and SIRT3 are cytoplasmic and mitochondrial NAD-dependent deacetylases. SIRT2 and SIRT3 target proteins involved in metabolic, proliferation and inflammation pathways and have been implicated in the pathogenesis of neurodegenerative, metabolic and oncologic disorders. Both pro- and anti-inflammatory effects have been attributed to SIRT2 and SIRT3, and single deficiency in SIRT2 or SIRT3 had minor or no impact on antimicrobial innate immune responses. Here, we generated a SIRT2/3 double deficient mouse line to study the interactions between SIRT2 and SIRT3. SIRT2/3<sup>-/-</sup> mice developed normally and showed subtle alterations of immune cell populations in the bone marrow, thymus, spleen, blood and peritoneal cavity that contained notably more anti-inflammatory B-1a cells and less NK cells. <i>In vitro</i>, SIRT2/3<sup>-/-</sup> macrophages favored fatty acid oxidation (FAO) over glycolysis and produced increased levels of both proinflammatory and anti-inflammatory cytokines. In line with metabolic adaptation and increased numbers of peritoneal B-1a cells, SIRT2/3<sup>-/-</sup> mice were robustly protected from endotoxemia. Yet, SIRT2/3 double deficiency did not modify endotoxin tolerance. Overall, these data suggest that sirtuins can act in concert or compensate each other for certain immune functions, a parameter to be considered for drug development. Moreover, inhibitors targeting multiple sirtuins developed for clinical purposes may be useful to treat inflammatory diseases.
Designing for Inclusion (2016)

We study how independent innovation teams develop an environment of inclusion to support gender diversity. Through a mixed-methods study involving surveys and interviews with people involved in independent innovation, we sought to better understand the mechanisms by which their teams fostered a sense of inclusion to support gender diversity via interpersonal practices and communication and collaboration technology usage. By understanding how inclusion supports gender diversity, we discuss design implications to help more diverse independent innovation teams form and function.
Effect of network topology on the controllability of voter model dynamics using biased nodes (2014)

This paper examines the effects of biased nodes on the voter model dynamics where each node is characterized by binary states s <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">i</inf> = ±1. For a fully connected graph, the master equation is shown to have the form of the Fokker-Planck equation, and necessary and sufficient conditions for the existence of a polynomial solution are investigated. Numerical simulations and analytical results are studied for a complete graph and the Erdös-Rényi network to reveal several interesting characteristics of the dynamical system. One of the key findings is that the equilibrium probability density of the network can be controlled by selecting the size of the influence groups. Population size, relative size of the biased groups, initial conditions and network parameters such as connection probabilities are discussed and their effects on the equilibrium probability density and time to convergence are investigated and reported.
Peptic Ulcer Therapy with Lansoprazole and Helicobacter pylori Eradication (1995)

This study investigated the relationship between the clearance of Helicobacter pylori and the healing rate of ulcers after treatment with lansoprazole. Lansoprazole 30 mg/day was administered to 124 gastric ulcer (GU) patients and 57 duodenal ulcer (DU) patients. The healing rates were 89.6% in GU and 96.5% in DU. The rate of shift to the S2 stage of healing was 33.1% in GU and 38.6% in DU. The H. pylori-positive rate was 69.7% in GU and 74.5% in DU. H. pylori clearance rates after lansoprazole treatment were 43.4% in GU and 51.2% in DU. In GU, the ulcer healing rate in the H. pylori-positive to -negative group was significantly higher than that in the group that remained H. pylori-positive, but there were no significant differences in the rate of shift to the S2 stage of ulcer healing. In DU, there were no significant differences in either the healing rates or the rates of shift to the S2 stage of ulcer healing. This suggests that the clearance of H. pylori results in a high healing rate in GU.
Towards efficient private spatial information retrieval using GPUs (2014)

Latest generation mobile devices allow users to receive services tailored to their current locations. Location-based service providers perform spatial queries based on the user locations, but may also share them with various third parties. User whereabouts may disclose sensitive details about an individual's health status, political views or lifestyle choices, and therefore must be thoroughly protected. Private information retrieval (PIR) methods support blind execution of range and NN queries with cryptographic-strength security, but incur significant performance overhead. We employ graphical processing units (GPUs) to speed up the crypto operations required by PIR. We identify the challenges that arise when using GPUs for this purpose, and we propose solutions to address them. To the best of our knowledge, this is the first work to use GPUs for efficient private spatial information retrieval, and an important first step towards GPU-based acceleration of a broader range of secure spatial data operations.
THE SPECIFICITY OF THE REACTION OF PHENYLHYDRAZINE WITH 17,21-DIHYDROXY-20-KETOSTEROIDS (1955)

Journal Article THE SPECIFICITY OF THE REACTION OF PHENYLHYDRAZINE WITH 17,21-DIHYDROXY-20-KETOSTEROIDS Get access ROBERT H. SILBER, PH.D., ROBERT H. SILBER, PH.D. 1Merck Institute for Therapeutic Research Rahioay, New Jersey Search for other works by this author on: Oxford Academic Google Scholar ROBERT D. BUSCH, PH.D. ROBERT D. BUSCH, PH.D. 1Merck Institute for Therapeutic Research Rahioay, New Jersey Search for other works by this author on: Oxford Academic Google Scholar The Journal of Clinical Endocrinology & Metabolism, Volume 15, Issue 4, 1 April 1955, Pages 505–507, https://doi.org/10.1210/jcem-15-4-505 Published: 01 April 1955
Pharmacokinetics of quazepam, being taken in two hours and eleven hours after a meal (2001)

s: The 10th Annual Meeting of the Japanese Society of Clinical Neuropsychopharmacology, Tokyo, Japan, 15-16 November 2000
Research and development of a CAD/CAM system based on B/S modefor sheet metal unforming and cutting (2003)

A CAD/CAM system based on B/S mode for sheet metal is developed? Some key realization methods and some key technologies,such as the input ?identification and distillation of part information,the creation of NC code,and the dynamic process simulation on the browser end are discussed.
Inversion of long-offset TEM soundings near the borehole Münsterland 1, Germany, and comparison with MT measurements (1992)

Data from a long-offset transient electromagnetic (LOTEM) survey in northwest Germany around the borehole Münsterland 1 are interpreted using 1-D inversion. Special emphasis is given to the fact that the best-fitting model is not necessarily the most realistic one. We therefore investigate different inversion algorithms in order to obtain a more geologically meaningful result.
Effect of (-)hydroxycitrate on the activities of ATP citrate lyase and the enzymes of acetyl-CoA metabolism in rat brain. (1976)

1. (-)Hyrdoxycitrate is a potent inhibitor of ATP citrate (pro-3S)lyase (EC 4.1.3.8) from rat brain, the inhibition being uncompetitive with respect to MgATP2-and competitive with citrate (Ki 0.8 muM). 2. The rate of oxygen consumption by rat brain synaptosomes and the activities of fatty acid synthetase, carnitine acetyltransferase, glucose-6-phosphate dehydrogenase and acetyl-CoA-synthetase are not affected by (-)hydroxycitrate. 3. (-)Hydroxycitrate inhibits the activities of isocitrate dehydrogenase, malate dehydrogenase (decarboxylating) and aconitate hydratase at millimolar concentrations.
A high-speed low-voltage stress-induced micromachined 2 x 2 optical switch (1999)

A low-voltage electrostatically actuated 2×2 fiber optic switch is achieved using a stress-induced curved polysilicon actuator. The curved polysilicon beam substantially lowers the electrostatic operating voltage of the switch. Large mirror displacement (300 μm) and low operating voltage (20 V) are obtained simultaneously. Sub-millisecond switching time (<600 μs), low optical insertion loss (0.7 dB), and small polarization-dependent loss (0.09 dB) have been achieved.
An open-source and cross-platform framework for Brain Computer Interface-guided robotic arm control (2012)

Brain Computer Interfaces (BCIs) have focused on several areas, of which motor substitution has received particular interest. Whereas open-source BCI software is available to facilitate cost-effective collaboration between research groups, it mainly focuses on communication and computer control. We developed an open-source and cross-platform framework, which works with cost-effective equipment that allows researchers to enter the field of BCI-based motor substitution without major investments upfront. It is based on the C++ programming language and the Qt framework, and offers a separate class for custom MATLAB/Simulink scripts. It has been tested using a 14-channel wireless electroencephalography (EEG) device and a low-cost robotic arm that offers 5° of freedom. The software contains four modules to control the robotic arm, one of which receives input from the EEG device. Strengths, current limitations, and future developments will be discussed.
Dynamics of Nanometer-Scale Foil Targets Irradiated with Relativistically Intense Laser Pulses (2010)

In this letter we report on an experimental study of high harmonic radiation generated in nanometer-scale foil targets irradiated under normal incidence. The experiments constitute the first unambiguous observation of odd-numbered relativistic harmonics generated by the $\vec{v}\times\vec{B}$ component of the Lorentz force verifying a long predicted property of solid target harmonics. Simultaneously the observed harmonic spectra allow in-situ extraction of the target density in an experimental scenario which is of utmost interest for applications such as ion acceleration by the radiation pressure of an ultraintense laser.
Genomic transcription factor binding site selection is edited by the chromatin remodeling factor CHD4 (2023)

Abstract Biologically precise enhancer licensing by lineage-determining transcription factors enables activation of transcripts appropriate to biological demand and prevents deleterious gene activation. This essential process is challenged by the millions of matches to most transcription factor binding motifs present in many eukaryotic genomes, leading to questions about how transcription factors achieve the exquisite specificity required. The importance of chromatin remodeling factors to enhancer activation is highlighted by their frequent mutation in developmental disorders and in cancer. Here we determine the roles of CHD4 to enhancer licensing and maintenance in breast cancer cells and during cellular reprogramming. In unchallenged basal breast cancer cells, CHD4 modulates chromatin accessibility at transcription factor binding sites; its depletion leads to altered motif scanning and redistribution of transcription factors to sites not previously occupied. During GATA3-mediated cellular reprogramming, CHD4 activity is necessary to prevent inappropriate chromatin opening and enhancer licensing. Mechanistically, CHD4 competes with transcription factor-DNA interaction by promoting nucleosome positioning over binding motifs. We propose that CHD4 acts as a chromatin proof-reading enzyme that prevents inappropriate gene expression by editing binding site selection by transcription factors.
EXHORTA EL RECTOR A SUPERAR EL NIVEL ACADEMICO (1988)

AL RENDIR SU INFORME DE LABORES 1987, EL RECTOR JORGE CARPIZO, SE REFIRIO A ASUNTOS CORRESPONDIENTES A PLANEACION Y EVALUACION, ENSENANZA MEDIA SUPERIOR, LA EDICION DE LIBROS DENTRO DE LA UNAM, ENTRE OTROS. HIZO HINCAPIE EN LA EXHORTACION A LA COMUNIDAD ESTUDIANTIL PARA REALIZAR UN VERDADERO ESFUERZO POR ESTUDIAR MAS Y APRENDER VERDADERAMENTE, YA QUE CON ELLO PODRAN OBTENER LA SATISFACCION COMO SERES HUMANOS Y UNA VIDA DECOROSA, ASI COMO SER BUENOS PROFESIONALES PARA SERVIR BIEN A LA SOCIEDAD.
Pungent products from garlic activate the sensory ion channel TRPA1 (2005)

Garlic belongs to the Allium family of plants that produce organosulfur compounds, such as allicin and diallyl disulfide (DADS), which account for their pungency and spicy aroma. Many health benefits have been ascribed to Allium extracts, including hypotensive and vasorelaxant activities. However, the molecular mechanisms underlying these effects remain unknown. Intriguingly, allicin and DADS share structural similarities with allyl isothiocyanate, the pungent ingredient in wasabi and other mustard plants that induces pain and inflammation by activating TRPA1, an excitatory ion channel on primary sensory neurons of the pain pathway. Here we show that allicin and DADS excite an allyl isothiocyanate-sensitive subpopulation of sensory neurons and induce vasodilation by activating capsaicin-sensitive perivascular sensory nerve endings. Moreover, allicin and DADS activate the cloned TRPA1 channel when expressed in heterologous systems. These and other results suggest that garlic excites sensory neurons primarily through activation of TRPA1. Thus different plant genera, including Allium and Brassica, have developed evolutionary convergent strategies that target TRPA1 channels on sensory nerve endings to achieve chemical deterrence.
Gènes chimériques mitochondriaux et stérilité mâle (1995)

National audience
CD8+ T lymphocyte-mediated lysis of Chlamydia -infected L cells using an endogenous antigen pathway. (1994)

Intracellular bacterial pathogens have evolved to either grow in the nutrient-rich cytoplasm or remain sequestered within a vacuole. One potentially important selective advantage for growth within a vacuole may be evasion of cell-mediated detection and cytolysis. To address this question we used the endosomally confined bacterium Chlamydia trachomatis, which naturally infects epithelial cells, to examine CTL-mediated lysis of nonphagocytic cells. CTL-mediated lysis of infected target cells was detected, although the increased expression of ICAM-1 by transfection was required. The elimination of CD8+ T cells or addition of brefeldin A or cycloheximide eliminated specific cytolysis, whereas conversely, treatment with chloroquine or ammonium chloride had only minor effects. These results implicate endogenous Ag processing for Chlamydia-specific cytolysis. This work demonstrates CTL-mediated lysis of cells infected with an intracellular bacterium that inhibits lysosomal fusion and is confined to an endosomal vacuole.
Isolation and characterization of several plasma apolipoproteins of common marmoset monkey. (1990)

To explore the potential of the common marmoset monkey (Callithrix jacchus) as a model for human plasma lipoprotein metabolism, several marmoset apolipoproteins were isolated and characterized in this study. Based on several properties, including molecular weight, amino acid composition, and sequence, the marmoset apolipoproteins are strikingly similar to human apolipoprotein (apo) A-I, A-II, C-III, and A-IV. The first 54 residues of marmoset apo A-I showed 87% sequence identity with the corresponding region of human apo A-I. Amino-terminal sequence analysis of a minor basic apo A-I isoform revealed that it contained an amino-terminal hexapeptide extension (Arg-His-Phe-Gln-Gln-) identical to that found in human proapo A-I. Like apo A-II in most nonhuman primates, marmoset apo-A-II differed from human apo A-II in that it did not contain cysteine and therefore existed as a monomer. The complete amino acid sequence of marmoset apo A-II was deduced. The protein contains 77 amino acids, as does human apo A-II, and showed an 82% identity with its human equivalent. In both species, apo C-III and E had similar amino-terminal sequences and amino acid compositions. Like human apo E, marmoset apo E contained minor sialylated isoforms. However, unlike human apo C-III, no sialyated isoforms of marmoset apo C-III were observed. In addition, the marmoset possessed an apolipoprotein whose molecular weight and amino acid composition were similar to those of human apo A-IV. The close structural similarities between corresponding marmoset and human apolipoproteins indicate that the marmoset monkey will be useful as a model for human lipoprotein metabolism.
Cotreatment with Pioglitazone, a Synthetic Ligand for Peroxisome Proliferator-Activated Receptor γ (PPARγ), Enhances Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)-Induced Apoptosis of Human Leukemia Cells. (2004)

Abstract Imatinib (STI571, Glivec) is the choice treatment for Bcr/Abl-positive malignancies. Emergence of resistance to Imatinib warrants the exploration of novel well-tolerated anticancer agents. Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor family, which mainly associates with the adipocyte differentiation, but also appears to facilitate cell differentiation or apoptosis in certain malignant cells. Previous studies imply that the PPARγ activation pathway may be a possible intervention mode for treatment of leukemia, which is resistant to imatinib (STI571). In this study, we investigated the effects of pioglitazone, a synthetic ligand for PPARg, on the cell growth and TRAIL-induced apoptosis in a novel imatinib (STI571) resistant acute myeloid cell line (SR-1), which we have established from an STI571 resistant blast crisis patient, as well as HL-60 cells. HL-60 and SR-1 cells are relatively resistant to TRAIL-induced apoptosis. Pioglitazone alone inhibited the cell growth of SR-1 and HL-60 cells, but did not induce the apoptosis of these cell lines. However, simultaneous exposure of cells to 100 ng/ml TRAIL with either 25 μM pioglitazone or 50 μM piogliazone resulted in a striking increase in apoptosis. To clarify the mechanism of pioglitazone to sensitize the leukemia cells to TRAIL-induced apoptosis, we investigated the change of the proteins related to cell cycle and apoptosis by western blot. As results, we observed the significant decrease of X-linked inhibitor of apoptosis (XIAP) and the increased expression of p21 by cotreatment of pioglitazone with TRAIL. Taken together, these findings indicate that pioglitazone may have promising activity in augmenting TRAIL-induced apoptosis of human acute leukemia cells including the imatinib (STI571) resistant acute myeloid cell line.
Optimal 2D-SIM reconstruction by two filtering steps with Richardson-Lucy deconvolution (2016)

Structured illumination microscopy relies on reconstruction algorithms to yield super-resolution images. Artifacts can arise in the reconstruction and affect the image quality. Current reconstruction methods involve a parametrized apodization function and a Wiener filter. Empirically tuning the parameters in these functions can minimize artifacts, but such an approach is subjective and produces volatile results. We present a robust and objective method that yields optimal results by two straightforward filtering steps with Richardson-Lucy-based deconvolutions. We provide a resource to identify artifacts in 2D-SIM images by analyzing two main reasons for artifacts, out-of-focus background and a fluctuating reconstruction spectrum. We show how the filtering steps improve images of test specimens, microtubules, yeast and mammalian cells.
RISK ASSESSMENT OF A SHRIMP AQUACULTURE INVESTMENT IN FLORIDA (2010)

Abstract A stochastic simulation model was developed to examine the impact of risky economic variables on the profitability of a small-scale shrimp farm. Sources of risk included input and output prices, random-kill events, and hurricane damages. Success was measured using the probability distribution of the net present value (NPV). A baseline model that assumed capital costs of $493,993, a stocking density of 100 shrimp per m2, a harvest survival of 80%, and a discount rate of 8% failed to generate a positive NPV. Subsequently adding a $0.66 price premium also failed to establish a positive NPV. Further reducing initial capital costs by 50% resulted in a 2% probability of a positive NPV. Incrementally reducing the discount rate generated increasingly positive NPV probabilities ranging from a 9% probability of success (7% discount rate) to a 94% probability of success (3% discount rate). Additional analyses suggested that probabilities of financial success were also sensitive to random-kill and hurricane events. Keywords: aquacultureinvestmentshrimpSimetarsimulationvannamei
Sintered Hydroxyapatite Ceramic for Wear Studies (1978)

A sintered hydroxyapatite (HAP) ceramic for use in wear studies was prepared from a commerical tricalcium phosphate. The sintered HAP had physical properties close to those of human enamel. The coefficient of friction and wear of the sintered HAP ceramic as characterized by tangential force, track width, and surface failure data, approximated those of human enamel.
A bending sensor insensitive to pressure: soft proprioception based on abraded optical fibres (2020)

Optical sensors have recently been proposed for sensing bending, linear strains and external forces in soft actuators. However, the susceptibility of these sensors to a number of stimuli makes it difficult to comprehend the resulting data output. We address this challenge through the introduction of a low-cost flexible bending sensor based upon the abrasion of optical channels. Such sensors are responsive to bending while being insensitive to internal pressure or external forces. The developed sensor is integrated into a soft pneumatic finger in order to obtain feedback of its curvature. We further demonstrate that the sensor is insensitive to normal forces applied on a blocked finger. Through this work, we propose a simple, low-cost sensor development technique towards addressing the challenge of decoupling forces and deformations in soft robots.
Primaquine Therapy for Malaria (2004)

Primaquine is the only available drug for preventing relapse of malaria, and confusion surrounds its use. This review examines the wide range of clinical applications of primaquine described in the medical literature between 1946 and 2004. The risk of relapse of Plasmodium vivax malaria without primaquine therapy ranged from 5% to 80% or more, depending largely upon geographic location. Supervision of therapy profoundly impacts the risk of relapse, and almost all reports of malaria resistant to primaquine are associated with lack of such supervision. We nonetheless suspect that there is widespread resistance to the standard course of primaquine therapy, which is 15 mg primaquine base daily for 14 days. Clinical evidence confirms that a course of 15 mg daily for just 5 days, a regimen widely used in areas where malaria is endemic, has no discernible efficacy. This review supports a recommendation for a regimen of 0.5 mg/kg primaquine daily for 14 days, on the basis of superior efficacy and good tolerability and safety in nonpregnant persons without glucose-6-phosphate dehydrogenase deficiency.