gebhart/patrepeval huggingface dataset:
Persistent impairment of mitochondrial and tissue redox status during lithium‐pilocarpine‐induced epileptogenesis (2010)

Mitochondrial dysfunction and oxidative stress are known to occur following acute seizure activity but their contribution during epileptogenesis is largely unknown. The goal of this study was to determine the extent of mitochondrial oxidative stress, changes to redox status, and mitochondrial DNA (mtDNA) damage during epileptogenesis in the lithium-pilocarpine model of temporal lobe epilepsy. Mitochondrial oxidative stress, changes in tissue and mitochondrial redox status, and mtDNA damage were assessed in the hippocampus and neocortex of Sprague-Dawley rats at time points (24h to 3months) following lithium-pilocarpine administration. A time-dependent increase in mitochondrial hydrogen peroxide (H(2)O(2)) production coincident with increased mtDNA lesion frequency in the hippocampus was observed during epileptogenesis. Acute increases (24-48h) in H(2)O(2) production and mtDNA lesion frequency were dependent on the severity of convulsive seizure activity during initial status epilepticus. Tissue levels of GSH, GSH/GSSG, coenzyme A (CoASH), and CoASH/CoASSG were persistently impaired at all measured time points throughout epileptogenesis, that is, acutely (24-48h), during the 'latent period' (48h to 7days), and chronic epilepsy (21days to 3months). Together with our previous work, these results demonstrate the model independence of mitochondrial oxidative stress, genomic instability, and persistent impairment of mitochondrial specific redox status during epileptogenesis. Lasting impairment of mitochondrial and tissue redox status during the latent period, in addition to the acute and chronic phases of epileptogenesis, suggests that redox-dependent processes may contribute to the progression of epileptogenesis in experimental temporal lobe epilepsy.
Selective anteromedial bundle reconstruction in partial ACL tears: a series of 36 patients with mean 24 months follow‐up (2009)

The purpose of this study was to describe an original technique of reconstruction of the anteromedial bundle preserving the posterolateral bundle and to report the results of a consecutive 36 patients series with mean 24 months follow-up. Our hypothesis is that this selective reconstruction of ACL partial tears could restore knee stability and function. In a consecutive series of 256, ACL reconstructions, 36 patients in which intact ACL fibers remained in the location corresponding to the posterolateral bundle were perioperatively diagnosed. These patients (21 women and 15 men) underwent isolated reconstruction of the anteromedial bundle while keeping the remaining fibers intact. AM bundle reconstructions were performed by the same surgeon using an outside-in technique. A quadrupled hamstring graft was used in 20 patients and a doubled semitendinosus graft in 16 patients. The mean age of the patients at the time of surgery was 32 years (min 15, max 53). The delay between injury and surgery was 6.6 months (min 2, max 35). Patients were assessed with the IKDC ligament evaluation form. Instrumented knee testing was performed with the Rolimeter arthrometer. Statistical analysis was performed to compare the preoperative and postoperative objective evaluation. Eleven concomitant meniscal lesions at the time of reconstruction were found. One patient who underwent a traumatic graft rupture at 4 months post surgery and two patients with previous contralateral ACL reconstruction were excluded, leaving 33 patients for final evaluation. Three reoperations were performed, including two arthrolysis for cyclops syndrome and one revision for a traumatic graft rupture. At last follow-up, 24 (73%) patients were graded A, 8 (24%) graded B and 1 C (3%) at IKDC objective evaluation. Mean side to side instrumented laxity was 4.8 mm (min 3, max 6) preoperatively and 0.8 mm (min 0, max 2) postoperatively. AM bundle reconstruction with an outside-in technique remains simple and reproducible. The preliminary results are encouraging with excellent side to side laxity. Graft size should probably be adapted to limit cyclops syndrome occurrence.
Investigation of the structural and functional relationships of oncogene proteins (2002)

Proteins are the biomolecular workhorses driving the most biological processes in any living organism. These processes are based on selective interactions between particular proteins. So far the rules governing the coding of the protein's biological function, i.e. its ability to selectively interact with other biomolecules, have not been elucidated The resonant recognition model (RRM) is a novel physicomathematical approach established to analyze the interaction between a protein and its target. The RRM assumes that the specificities of protein interactions are based on the resonant electromagnetic energy transfer at the specific frequency for each interaction. One of the main applications of this model is to predict the location of a protein's biological active site(s) using digital signal processing. This paper incorporates the continuous wavelet transform (CWT) into the RRM to predict the active sites for a chosen protein example. We have investigated the oncogene functional group using digital signal analysis methods, in particular Fourier transform and CWT determined oncogenes' characteristic frequency and functional active sites; and performed the design of the peptide analogous. The results obtained provide new insights into the structure-function relationships of the analyzed oncogene protein family.
Release of cariostatic agents from a new buffering fluoride‐ and xylitol‐containing lozenge to human whole saliva in vivo (1997)

A new buffering lozenge (sucking tablet) was developed for patients susceptible to dental caries and erosion, in particular for those with reduced salivary secretion. As active ingredients this lozenge comprises of a combination of xylitol, fluoride, calcium, phosphate, zinc and buffering compounds. To test the lozenge's activity in vivo, the release of ingredients was monitored in 19 healthy subjects for 22 min after sucking the lozenge was completed. In subjects with a normal salivary secretion rate the lozenge caused only a slight stimulation of saliva flow, but a significant elevation both in salivary pH and buffer effect was observed. Furthermore, fluoride, calcium and phosphate were effectively released into whole saliva with peak values 2-4 min after use. The same salivary parameters were also quantitated after 1 month's regular use (3 lozenges/day) but no consistent long-term changes were found. Salivary mutans streptococci and total anaerobic microflora did not change significantly during the long-term use. The results show that the buffering fluoride- and xylitol-containing lozenge, which also releases calcium and phosphate, is active in vivo but its serviceability as a remineralizing agent, in particular for elderly patients with reduced salivary flow rate, has to be analysed separately.
ChemInform Abstract: Oxidations of C—H and C=C Bonds (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Simultaneous gain and phase-shift enhancements in periodic gain structures (1990)

The recently proposed concept of periodic gain, i.e., dividing the active region into segments placed at optical electric-field standing wave maxima, has been shown to greatly reduce the threshold gain requirement of the active media by up to a factor of 2 in high-finesse vertical cavity surface-emitting lasers. The lasing wavelength is determined by the period of the standing wave; however, previous analyses of these structures have failed to show that a similar enhancement effect occurs for the index shift resulting from the active segments as well. In this communication, we show that effects on both gain and index can be rigorously derived from conventional transmission scattering theory.
Growth hormone and ageing (2011)

Abstract Ageing is characterized by undesirable changes in body composition and a decline in many physiological functions, leading to reduced physical fitness and increased susceptibility to illness. With the projected growth of the elderly population worldwide, the ageing process is likely to give rise to increasing demands on health and welfare service budgets. The WHO projects that between the years 2000 and 2050, the world’s population of persons aged 60 and over will more than triple, from 600 million to 2 billion (1). The proportion of the EU population aged 65 years and over is predicted to rise from 17.1% in 2008 to 30.0% in 2060, and the proportion aged 80 and over to rise from 4.4% to 12.1% over the same period (2). Ageing is a complex and poorly understood process. In recent years, there has been considerable interest in the role of the growth hormone/insulin-like growth factor 1 (GH/IGF-1) axis. Prior to 1985, supplies of GH were limited as it was obtainable only from human pituitary tissue, largely restricting its use to the treatment of childhood short stature. The development of recombinant GH has made available theoretically infinite supplies of GH, and allowed exploration of the role of GH in adult pathophysiology. While GH is best recognized for its stimulation of longitudinal bone growth in childhood, recent evidence has demonstrated that GH continues to play a central role in adulthood in the regulation of fat and protein metabolism, body composition, and many physiological functions. The steady decline in GH secretion through adulthood, termed the ‘somatopause,’ raises the possibility of involvement of the GH/IGF-1 axis in the structural and functional changes that accompany advancing age. This chapter explores the role of the somatopause and reviews the evidence for GH as a strategy for modifying age-related deterioration.
Fast trajectory tracking based on flatness control for a high voltage AC-DC-AC power system (2018)

The main objective is to design a fast trajectory tracking control for a complete high voltage DC (HVDC) power system connecting wind generators to an AC grid which also incorporates conventional converters. For such nonlinear dynamics an original flatness-based feedback is derived which enables the controlled shifting from one to another steady state without inducing any appreciable transient. Simulation results are presented which well confirm the predicted behaviour.
BLADE: Filter Learning for General Purpose Image Processing (2018)

The Rapid and Accurate Image Super Resolution (RAISR) method of Romano, Isidoro, and Milanfar is a computationally efficient image upscaling method using a trained set of filters. We describe a generalization of RAISR, which we name Best Linear Adaptive Enhancement (BLADE). This approach is a trainable edge-adaptive filtering framework that is general, simple, computationally efficient, and useful for a wide range of image processing problems. We show applications to denoising, compression artifact removal, demosaicing, and approximation of anisotropic diffusion equations.
Oxidative Folding of Peptides and Proteins (2008)

The formation of disulfide bonds is probably the most influential modification of peptides and proteins. An elaborate set of cellular machinery exists to catalyze and guide this process. In recent years, significant developments have been made in both our understanding of the in vivo situation and the in vitro manipulation of disulfide bonds. This is the first monograph to provide a comprehensive overview of this exciting and rapidly developing area. It offers in-depth insights into the mechanisms of in vivo and in vitro oxidative folding of proteins as well as mono- and multiple-stranded peptides. Procedures applied for laboratory and industrial purposes are also discussed by top experts in the field. The book describes the enzymes involved in the correct oxidative folding of cysteine-containing proteins in prokaryotes and eukaryotes. It then goes on to discuss the mimicking of these enzymes for successful in vitro folding of proteins (including synthetic replicates) and to deal with important issues concerning cysteine-rich peptides. The ability of natural bioactive peptides to fold correctly, and in high yields, to form defined structural motifs using cysteine sequence patterns is still puzzling. With this in mind, synthetic procedures for establishing native cysteine frameworks are discussed using selected examples, such as the potential of selenocysteines. The biotechnological and pharmaceutical relevance of proteins, peptides, their variants and synthetic replicates is continuously increasing. Consequently, this book is invaluable for peptide and protein chemists involved in related research and production.
Analysis of the proliferative potential of residual tumor after radiosurgery for intraparenchymal brain metastases (1996)

A retrospective immunohistochemical study of radiosurgically treated brain metastases was performed to determine whether residual tumor has reduced proliferative potential. The monoclonal antibodies MIB-10 and PC-10 were used as markers for proliferation. The experimental group consisted of pathological specimens obtained from five patients in whom brain metastasis previously had been treated with radiosurgery. Pathological specimens obtained from 10 patients with brain metastases, matched in histology to diseases in the experimental group but untreated by radiosurgery, served as controls. A significant decrease in proliferative indices was observed in metastatic brain cancers after radiosurgery (p < 0.001). These results indicate that the persistent tumor that is present at the site of a metastasis previously treated with radiosurgery is less viable and may not in itself be a significant finding.
Purification and differential expression of enolase from maize (1994)

Enolase was purified from maze ( Zea mays L. inbred B73)seeds to a 55 and 56 kDa protein doublet based upon sodium dodecyl sulfate – polyacrylamide gel electrophoresis. Purification included ammonium sulfate‐precipitation, gel filtration, Mono Q, and Phenyl Superose chromatography. Two‐dimensional gels further resolved the 56 kDa protein into three isoselectric forms. Polyclonal antibodies raised against the purified proteins, were found to bind specifically to both the 55 and 56 kDa proteins during purification. Theses antibodies did not recognized a 56 kDa protein when the strain was complemented with maize enolase (pZM245). Maize enolase antibodies recognized a extracts indicated that the 55 kDa form of enolase was more abundant in roots. Enolase protein levels remained unchanged in maize roots after 24 h of anaerobiosis, even though the specific activity of enolase increased to twice its initial levels. A plastid form of enolase in maize could not be found as either enolase activity or protein (with immunoblots).
Variation of Thermal Emittance of Thermal Control Materials during Simultaneous Irradiation of Electrons and Ultraviolet Rays (1987)

&lt;div class="htmlview paragraph"&gt;Variation of the total hemispherical emittance of spacecraft thermal control films resulting from irradiation is discussed. An electron energy of 30 KeV and a UV intensity of 3 sun equivalents are used. The emittance is measured in situ by the calorimetric method. The emittance of silver-Teflon film increases slightly with increasing the electron fluence. Its increment is less than 0.02 at a fluence of 1 × 10&lt;sup&gt;15&lt;/sup&gt; e/cm&lt;sup&gt;2&lt;/sup&gt;, and very small for further irradiation. Addition of UV rays does not alter this situation. The emittance of aluminized Kapton film is not changed appreciably by irradiation.&lt;/div&gt;
Comparison of Two Different Methods for Measurement of Amyloid-β Peptides in Cerebrospinal Fluid after BACE1 Inhibition in a Dog Model (2013)

Beta-secretase is the first cleavage enzyme of amyloid-β protein precursor (AβPP) in the amyloidogenic pathway, leading to the formation of the plaque forming Amyloid-β (Aβ)1-42 peptide. BACE (beta-site AβPP cleaving enzyme) 1 inhibition is therefore considered to be a promising disease modifying therapy for Alzheimer's disease. An early assessment of the in vivo activity of BACE inhibitors was done in dogs since AβPP processing is the same as in humans and this species easily enables longitudinal cerebrospinal fluid (CSF) sampling. Aβ changes in CSF compared to baseline are used to evaluate target engagement of the compounds. Levels of Aβ1-37, Aβ1-38, Aβ1-40, and Aβ1-42 in CSF are measured with immunoassay (Mesoscale electrochemiluminescence technology) and with an ultra high-performance liquid chromatography mass spectrometry (UPLC-MS/MS). Two experimental BACE inhibitors were evaluated. With the immunoassay, a dose dependent decrease is observed for all four Aβ peptides. Measurements with the UPLC-MS/MS are in line with the immunoassay for Aβ1-37, Aβ1-38, and Aβ1-40, however, for Aβ1-42, differences are sometimes observed when comparing to changes seen in the other peptides with UPLC-MS/MS and with immunoassay results. Generally lower concentrations are measured with immunoassay. The reason for these differences is still unknown. Aβ1-42 is more prone to form aggregates compared to the other peptides. One hypothesis could be that while the immunoassay only measures free Aβ, bound and aggregated Aβ peptides are at least partially dissolved with the UPLC-MS/MS method, since acetonitrile is added to the CSF samples. This increases variability in the concentration of Aβ peptide measured with UPLC-MS/MS, especially for Aβ1-42, potentially masking the compound effect on Aβ1-42 levels.
Train-of-four Nerve Stimulation in the Management of Prolonged Neuromuscular Blockade Following Succinylcholine (1975)

Four patients, all possessing an atypical form of plasma cholinesterase, developed prolonged paralysis following succinylcholine administration. The clinical management of all four cases was facilitated by monitoring the train-of-four stimulus. All patients showed marked "fade" of the train-of-four ratio, the initial ratios of the fourth to the first twitches being 50 per cent or less, indicating variable degrees of nondepolarizing neuromuscular blockade. Reversal of paralysis with anticholinesterase agents was completely successful in three cases, but only partially effective in the fourth because of the probable presence of a mixture of both depolarizing block and nondepolarizing block. In such a situation, caution in the interpretation of the train-of-four ratio is necessary, since this test measures only the nondepolarizing component of the block. Whether or not reversal with anticholinesterase drugs is attempted, clinical estimates of neuromuscular function, such as head lift, vital capacity, and inspiratory force, must be carefully correlated with train-of-four values. If reversal is attempted, the brief action of edrophonium provides a useful clinical trial.
Forecasting electricity consumption: A comparison of models for New Zealand (2004)

Forecasting electricity consumption is of national interest to any country. Future electricity forecasts are not only&#13;\nrequired for short and long term power planning activities but also in the structure of the national economy. This&#13;\npaper proposes six forecasting models developed for electricity consumption in New Zealand. Three of these models&#13;\n(Logistic, Harvey Logistic and Harvey) are based on growth curves. A further model uses economic and&#13;\ndemographic variables in multiple linear regression to forecast electricity consumption while another uses these&#13;\nfactors to estimate future saturation values of the New Zealand electricity consumptions and combine the results&#13;\nwith a growth curve model. The sixth model makes use of the Box-Jenkins ARIMA modeling technique. The&#13;\ndeveloped models are compared using goodness of fit, forecasting accuracy and future consumption values. The&#13;\nfuture consumptions are also compared with the available national forecasts. The comparisons revealed that the best&#13;\noverall forecasts are given by the Harvey model for both the Domestic and the Total electricity consumption of New&#13;\nZealand while a specific form of the Harvey model, the Harvey Logistic model, is the best in forecasting Non-&#13;\nDomestic electricity consumption.
Output coupling methods for cavity-based high-harmonic generation (2006)

We have investigated the coupling efficiency and cavity loss associated with a ring cavity that has a hole in one of the focusing mirrors. The aperture provides a means through which intracavity high-harmonic generation can be coupled from the cavity. By studying different cavity geometries and input modes we have found that the integration of phase-plates on the focusing mirrors provides the best performance in terms of input coupling efficiency, cavity loss, and output-coupling of the generated high harmonic light.
Distributed multimedia systems (1997)

A distributed multimedia system (DMS) is an integrated communication, computing, and information system that enables the processing, management, delivery, and presentation of synchronized multimedia information with quality-of-service guarantees. Multimedia information may include discrete media data, such as text, data, and images, and continuous media data, such as video and audio. Such a system enhances human communications by exploiting both visual and aural senses and provides the ultimate flexibility in work and entertainment, allowing one to collaborate with remote participants, view movies on demand, access on-line digital libraries from the desktop, and so forth. In this paper, we present a technical survey of a DMS. We give an overview of distributed multimedia systems, examine the fundamental concept of digital media, identify the applications, and survey the important enabling technologies.
DGPS-Calibrated Accelerometric System for Dynamic Sports Events (2000)

Keywords: gpsski ; topotraj Reference TOPO-CONF-2000-009 Record created on 2004-12-16, modified on 2016-08-08
Distributed system support for voice in Cedar (1986)

Voice management involves facilities for storing, editing, and referencing recorded voice. To record or playback votce, a conversation can be set up directly between an Etherphone and the Voice File Server. Once recorded, the voice is treated as immutable, Voice editing operations, rather than actually copying and re-arrat~gi,0g the voice samples, create voice objects consisting of ordered intervals of voice files. Programmer interfaces on the workstations allow voice to be easily integrated into Cedar applications.
Search for charge-asymmetric production of W′ bosons in tt¯+jet events from pp collisions at s=7 TeV (2012)

A search is presented for charge-asymmetric production of a W boson that has been proposed to accommodate the forward-backward asymmetry observed in the production of top-antitop quark pairs at the Tevatron. The new heavy W boson would be produced in association with a top quark and would decay into top and down quarks. The data correspond to an integrated luminosity of 5.0 fb -1 in pp collisions at a center-of-mass energy of 7 TeV, recorded by the CMS detector at the LHC. No significant excess above the standard model expectations is observed, and, from a combination of the electron-plusjets and muon-plus-jets channels, a 95% confidence level lower limit of 840 GeV/c 2 is set on the W boson mass for a W boson model with values for coupling constants to top and down quarks g L = 0 and g R = 2. In addition, a kinematic reconstruction of the W resonance mass using the inherent charge asymmetry of this model finds no indication of the presence of W events in the data.