gebhart/patrepeval huggingface dataset:
Venous thromboembolic complications in patients with malignant glioma treated on a bevacizumab clinical trial. (2011)

9090 Background: Although the prognosis for malignant glioma remains poor, the introduction of bevacizumab has improved survival for patients with this devastating illness. Bevacizumab is a humanized monoclonal antibody to vascular endothelial growth factor (VEGF). Patients with malignant gliomas are felt to have an incidence of thromboembolism in 20-30%. As patients with malignant gliomas are at increased risk for venous thrombosis by nature of their diagnosis, one worries about potentially increasing this risk with the addition of bevacizumab. Previous reports have shown an incidence of approximately 25% of venous thromboembolic disease in cancer patients receiving concurrent chemotherapy and bevacizumab. Methods: We performed a retrospective analysis of all clinical trial participants receiving bevacizumab for malignant glioma from April 2005 to January 2011. 617 patients with malignant glioma were included: 529 with glioblastoma (GBM) and 88 with anaplastic glioma (AG). Of those, 204 patients were newly diagnosed. This group was treated with standard temozolomide and radiation, combined with bevacizumab and a topoisomerase I inhibitor. 413 patients with recurrent tumors were included. Their treatment regimens varied, but all had progressed on standard therapy. After being diagnosed with a venous thromboembolic complication, patients were started on anticoagulation with heparin, low molecular weight heparin, or warfarin. They were followed until death or progression of disease. Results: The incidence of venous thrombosis was 7% (n=43), and incidence of pulmonary embolism was 2.9% (n=18). Of those, 1.3% (n=8) were patients with anaplastic glioma. Newly diagnosed patients represented only 2.3% (n=14). Of those patients, 0.6% (n=4) had a history of previous venous thrombosis but were no longer on anticoagulation. The mean time on treatment prior to diagnosis of the venous thromboembolic complication was 105.8 days; and a median time of 87 days. Of the patients treated for thromboembolic disease, 0.5% (n=3) had intracranial hemorrhage. Conclusions: Use of bevacizumab does not increase the risk of venous thromboembolic complications in patients with malignant gliomas.
ChemInform Abstract: Novel Hydroxyicosatetraenoic and Hydroxyicosapentaenoic Acids and a 13‐ Oxo Analog. Isolation from a Mixture of the Calcareous Red Algae Lithothamnion corallioides and Lithothamnion calcareum of Brittany Waters (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Cardiovascular regulation during sleep quantified by symbolic coupling traces (2010)

Sleep is a complex regulated process with short periods of wakefulness and different sleep stages. These sleep stages modulate autonomous functions such as blood pressure and heart rate. The method of symbolic coupling traces (SCT) is used to analyze and quantify time-delayed coupling of these measurements during different sleep stages. The symbolic coupling traces, defined as the symmetric and diametric traces of the bivariate word distribution matrix, allow the quantification of time-delayed coupling. In this paper, the method is applied to heart rate and systolic blood pressure time series during different sleep stages for healthy controls as well as for normotensive and hypertensive patients with sleep apneas. Using the SCT, significant different cardiovascular mechanisms not only between the deep sleep and the other sleep stages but also between healthy subjects and patients can be revealed. The SCT method is applied to model systems, compared with established methods, such as cross correlation, mutual information, and cross recurrence analysis and demonstrates its advantages especially for nonstationary physiological data. As a result, SCT proves to be more specific in detecting delays of directional interactions than standard coupling analysis methods and yields additional information which cannot be measured by standard parameters of heart rate and blood pressure variability. The proposed method may help to indicate the pathological changes in cardiovascular regulation and also the effects of continuous positive airway pressure therapy on the cardiovascular system.
Morphine-thebaine group of alkaloids. IX. Reaction of thebaine with magnesium iodide (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMorphine-thebaine group of alkaloids. IX. Reaction of thebaine with magnesium iodideKenneth W. BentleyCite this: J. Am. Chem. Soc. 1967, 89, 10, 2464–2469Publication Date (Print):May 1, 1967Publication History Published online1 May 2002Published inissue 1 May 1967https://pubs.acs.org/doi/10.1021/ja00986a039https://doi.org/10.1021/ja00986a039research-articleACS PublicationsRequest reuse permissionsArticle Views161Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The extension problem for Lee and Euclidean weights (2017)

The extension problem is solved for the Lee and Euclidean weights over three families of rings of the form $\Z/N\Z$: $N=2^{\ell + 1}$, $N=3^{\ell + 1}$, or $N=p=2q+1$ with $p$ and $q$ prime. The extension problem is solved for the Euclidean PSK weight over $\Z/N\Z$ for all $N$.
Water Use and Fertilizer Response of Azalea Using Several No-leach Irrigation Methods (2007)

Although research has shown that plants grown with subirrigation systems such as ebb-and-flow and capillary mat require less water and fertilizer inputs than traditional overhead irrigation methods, similar information for capillary wick irrigation has not been available. We compared the growth and water use response of azalea ( Rhododendron sp. ‘George Tabor’) grown in 6.5-inch-diameter “azalea” containers with three irrigation methods [overhead (OVR), subirrigation (SUB), and capillary wick (WCK)] and four fertilizer nitrogen (N) rates 0.5 to 2.0 lb/yard 3 supplied by an incorporated, resin-coated, controlled-release fertilizer (Nutricote 17N–3.1P–6.7K, 180 d at 77 °F). OVR volume was adjusted to deliver 100% of evapotranspiration (ET) loss. For all irrigation treatments, the lowest N rate resulting in maximum plant growth was 1.0 lb/yard 3 , which was less than the label recommendation of 1.5 lb/yard 3 . At the N-limiting N rate of 0.5 lb/yard 3 , irrigation method had no effect ( P &lt; 0.05) on azalea growth. At N rates higher than 1.0 lb/yard 3 , decreased growth was observed for OVR compared with SUB and WCK. This negative effect on plant growth was attributed to salt injury as indicated by excessive pour-through electrical conductivity (EC) levels in OVR containers. At the end of the experiment, substrate EC was highest in the uppermost layer of SUB and WCK containers, reflecting the upward movement of water associated with these two irrigation methods. Water use efficiency, which ranged from 1.9 to 2.8 g shoot dry weight per liter of water lost through ET, was unaffected ( P &lt; 0.05) by irrigation method at the N rate of 1.0 lb/yard 3 . We concluded that the growth response of azalea to fertilizer N rate was similar for WCK and SUB despite periodic pour-through EC tests indicating higher substrate nutrient levels with WCK.
In-Home Daily-Life Captioning Using Radio Signals (2020)

This paper aims to caption daily life --i.e., to create a textual description of people's activities and interactions with objects in their homes. Addressing this problem requires novel methods beyond traditional video captioning, as most people would have privacy concerns about deploying cameras throughout their homes. We introduce RF-Diary, a new model for captioning daily life by analyzing the privacy-preserving radio signal in the home with the home's floormap. RF-Diary can further observe and caption people's life through walls and occlusions and in dark settings. In designing RF-Diary, we exploit the ability of radio signals to capture people's 3D dynamics, and use the floormap to help the model learn people's interactions with objects. We also use a multi-modal feature alignment training scheme that leverages existing video-based captioning datasets to improve the performance of our radio-based captioning model. Extensive experimental results demonstrate that RF-Diary generates accurate captions under visible conditions. It also sustains its good performance in dark or occluded settings, where video-based captioning approaches fail to generate meaningful captions. For more information, please visit our project webpage: http://rf-diary.csail.mit.edu
Zero- to Ultralow-Field NMR Spectroscopy of Small Biomolecules (2020)

Nuclear magnetic resonance (NMR) spectroscopy is a well-established analytical technique used to study chemicals and their transformations. However, high-eld NMR spectroscopy necessitates advanced infrastructure and even cryogen-free benchtop NMR spectrometers cannot be readily assembled from commercially available components. We demonstrate construction of a portable zero-field NMR spectrometer employing a commercially available magnetometer and investigate its applications in analytical chemistry. In particular, J-spectra of small representative biomolecules [13C]-formic acid, [1-13C]-glycine, [2,3-13C]-fumarate, and [1-13C]-D-glucose were acquired and an approach relying on the presence of a transverse magnetic eld during the detection was investigated for relaxometry purposes. We found that water relaxation time strongly depends on the concentration of dissolved D-glucose in the range of 1-10 mM suggesting opportunities for indirect assessment of glucose concentration in aqueous solutions. Extending analytical capabilities of zero-field NMR to aqueous solutions of simple biomolecules (aminoacids, sugars and metabolites) and relaxation studies of aqueous solutions of glucose highlight the analytical potential of non-invasive and portable ZULF NMR sensors for applications outside of research laboratories.
Personalizing entity detection and recommendation with a fusion of web log mining techniques (2009)

Given the proliferation of technology sites and the growing diversity of their readership, readers are more and more likely to encounter specialized language and terminology that they may lack the sufficient background to understand. Such sites may lose readership and the experience of readers may be impacted negatively if readers cannot quickly and easily find information about terms they wish to learn more about. We developed a system using a fusion of web log mining techniques that extracts, identifies, and recommends personalized terms to readers by utilizing information found in individual and global web query logs. In addition, the system presents relevant information related to these terms inline with the text. Our system outperforms some other related systems developed in the literature with special regard to usability.
A Modified Dynamic Window Approach to Obstacle Avoidance Combined with Fuzzy Logic (2015)

As a classic reactive method for obstacles avoidance, the dynamic window approach (DWA) uses an objective function to choose the optimal velocity commands. The objective function consists of three weighted terms, respectively urging the robot to face to the target point, avoid crash and move fast. The environment where robot works is usually complex and changeable, and different situations need different weights. However, the original DWA and its extensions use constant weights, and there is no existing algorithm for changing them. In this paper, we propose a modified DWA combined with fuzzy logic. This can be done by analyzing the information about goal and obstacles, and then using fuzzy logic to decide suitable weights in real time. In contrast with the original DWA, the proposed method makes robot move more safely and smoothly.
Activity-Based Costing System in the Service Sector: A Strategic Approach for Enhancing Managerial Decision Making and Competitiveness (2011)

The author begins the article by outlining a brief historical evolution of activity-based costing (ABC) in the USApreceded by an operating definition of terminologies. Next, he presents the literature review and themethodology employed during the study. He reviews the application of ABC in the service sector, followed byan analysis of the unique attribute of the service sector. Moreover, the researcher briefly profiles severalservice-oriented firms that have successfully adopted and implemented ABC, and presents his findings from thestudy. He then addresses the limitations of ABC in the service sectors and offers strategies for dealing with thesedrawbacks. Finally, the researcher outlines the managerial implications of implementing ABC in the servicesector.
Human resource management in the changing business environment of the Indian construction industry: a case study (2013)

Subject area Human resource management. Study level/applicability The case can be used on courses related to human resources management (HRM), which are offered in management programmes like MBA/PGDBM. The case could also be used in management development programmes, seminars and workshops that have HRM as a component of the programme. The case can be used effectively for classroom discussions as well as in distance learning programmes. Case overview The case looks into the HRM practices at a leading Indian construction company – ABC Constructions. The case tries to explain the management perspectives behind the people practice initiatives undertaken by the company in order to recruit/retain and nurture talent. The case also explains the basic principles underlying its human resource policies. It tries to explain the initiatives taken by ABC Constructions to meet the challenges posed by the changing business environment, as the company moves beyond the borders of the country of its initial operations. The case provides an overview of unique challenges faced by a company in the Indian construction industry, where a significant number of people executing its projects are not its permanent employees. Expected learning outcomes The students would get a fairly good understanding of existing good practices in the field of human resource management, especially in the context of a multifaceted and labour intensive construction industry in the Indian corporate scenario. Anecdotes of actual experiences with respect to people management would facilitate greater understanding of the complexities involved at the grass root level of functioning and implementation. Theoretical inputs relating to training could be better understood through the customised programmes provided by the company for its diverse workforce. The HR challenges faced by the top management as a company grows and expands to new markets can better be understood. Supplementary materials Teaching notes are available for educators only. Please contact your library to gain login details or email support@emeraldinsight.com to request teaching notes.
Laparoscopic surgery for pelvic pain associated with endometriosis (2009)

Laparoscopic surgery results in improved pain outcomes when compared to diagnostic laparoscopy alone. There were few women diagnosed with severe endometriosis included in the meta-analysis and therefore any conclusions from this meta-analysis regarding treatment of severe endometriosis should be made with caution. It is not possible to draw conclusions from the meta-analysis which specific laparoscopic surgical intervention is most effective.
Top-Down Proteomic Identification of Shiga Toxin 1 and 2 from Pathogenic Escherichia coli Using MALDI-TOF-TOF Tandem Mass Spectrometry (2019)

Shiga-toxin-producing <i>Escherichia coli</i> (STEC) are a burden on agriculture and a threat to public health. Rapid methods are needed to identify STEC strains and characterize the Shiga toxin (Stx) they produce. We analyzed three STEC strains for Stx expression, using antibiotic induction, matrix-assisted laser desorption/ionization time-of-flight-time-of-flight (MALDI-TOF-TOF) mass spectrometry, and top-down proteomic analysis. <i>E. coli</i> O157:H- strain 493/89 is a clinical isolate linked to an outbreak of hemolytic uremic syndrome (HUS) in Germany in the late 1980s. <i>E. coli</i> O145:H28 strains RM12367-C1 and RM14496-C1 were isolated from an agricultural region in California. The <i>stx</i> operon of the two environmental strains were determined by whole genome sequencing (WGS). STEC strain 493/89 expressed Shiga toxin 2a (Stx2a) as identified by tandem mass spectrometry (MS/MS) of its B-subunit that allowed identification of the type and subtype of the toxin. RM12367-C1 also expressed Stx2a as identified by its B-subunit. RM14496-C1 expressed Shiga toxin 1a (Stx1a) as identified from its B-subunit. The B-subunits of Stx1 and Stx2 both have an intramolecular disulfide bond. MS/MS was obtained on both the disulfide-bond-intact and disulfide-bond-reduced B-subunit, with the latter being used for top-down proteomic identification. Top-down proteomic analysis was consistent with WGS.
ОСОБЕННОСТИ МАТРИЧНОГО СИНТЕЗА ПОЛИАНИЛИНА В ПРИСУТСТВИИ СМЕСИ МАТРИЦ РАЗЛИЧНОГО ТИПА И ИССЛЕДОВАНИЕ СВОЙСТВ ОБРАЗУЮЩИХСЯ ИНТЕРПОЛИМЕРНЫХ КОМПЛЕКСОВ (2009)

В работе впервые показано существование эффекта матричного доминирования в процессе формирования в растворах интерполимерного комплекса полианилина при окислении анилина в присутствии жестких и гибких полиамидосульфокислот.
Gait Asymmetry in People With Parkinson’s Disease Is Linked to Reduced Integrity of Callosal Sensorimotor Regions (2018)

People with PD showed increased step length asymmetries and decreased microstructural integrity of callosal white matter tracts connecting the higher-order sensorimotor cortices (pre-SMA and SMA). The strong association between gait asymmetries and corpus collosum integrity, supports the hypothesis that reduced transcallosal structural connectivity is a significant mechanism underlying gait asymmetries in people with PD.
Who Benefits from Increasing the Federal Deposit Insurance Limit (2001)

This Commentary seeks to shed light on the issue of deposit insurance coverage by examining who would benefit from increases in the insured-deposit limit.
[A case of effective photodynamic therapy for local recurrence after definitive chemoradiotherapy for esophageal cancer]. (2009)

We performed a photodynamic therapy for local recurrence after chemoradiotherapy for esophageal cancer. The patient was a 60s man, who presented dysphasia. Esophagoscopy, CT and FDG-PET revealed an advanced esophageal cancer with mediastinal lymph node metastasis. He rejected a surgical treatment and underwent chemoradiotherapy, then achieved CR once. Subsequent FDG-PET, however, showed slightly FDG uptake at primary focus of the esophagus. Endoscopic biopsy specimen from Lugol's unstained lesion of the esophagus revealed squamous cell carcinoma, and he was diagnosed as a recurrence of the esophageal cancer. He underwent chemotherapy again, but the recurrent lesion enlarged. Because the control of the metastatic lesion was excellent and the recurrent lesion was considered as a superficial cancer, he was performed photodynamic therapy. Two months after photodynamic therapy, the esophagoscopy and FDG-PET showed no findings of the recurrence of the esophageal cancer. It was suggested that photodynamic therapy for local recurrence after definitive chemotherapy for esophageal cancer was effective and relatively safe.
Impact of the Wetting Length on Flexible Blade Spreading (2020)

We study the spreading of a Newtonian fluid by a deformable blade, a common industrial problem, characteristic of elastohydrodynamic situations. Here, we consider the case of a finite reservoir of liquid, emptying as the liquid is spread. We evidence the role of a central variable: the wetting length l_{w}, which sets a boundary between the wet and dry parts of the blade. We show that the deposited film thickness e depends quadratically with l_{w}. We study this problem experimentally and numerically by integration of the elastohydrodynamic equations, and finally propose a scaling law model to explain how l_{w} influences the spreading dynamics.
Dopamine Stimulates Sodium Transport and Liquid Clearance in Rat Lung Epithelium (1997)

Pulmonary edema clearance is driven primarily by active sodium transport out of the alveoli, mediated predominantly by apical sodium channels and the basolateral NA,K-ATPase. We postulated that dopamine, analogous to its effects in other transporting epithelia, could regulate these sodium transport mechanisms and affect lung liquid clearance. We therefore studied the effects of dopamine on sodium transport and liquid clearance in isolated perfused rat lungs. Instillation of dopamine into the airways caused a dose-dependent increase in liquid clearance from isolated rat lungs of up to 33% above control values at 10(-8) to 10(-4) M concentrations. 10(-6) M amiloride, which selectively inhibits apical sodium channels, decreased basal liquid clearance by 34% but did not inhibit the dopamine-mediated stimulation of lung liquid clearance. Instillation of 10(-4) M amiloride into rat airways, which inhibits other sodium transport mechanisms non-selectively, decreased basal lung liquid clearance by 49% and inhibited the dopamine-mediated stimulation of lung liquid clearance. Perfusion of rat lungs with 5 x 10(-4) M ouabain to specifically inhibit Na,K-ATPase reduced both basal clearance (by 55%) and the dopamine-stimulated increase in lung fluid clearance. Conceivably, the stimulation of lung liquid clearance by dopamine is due to a modulation of Na,K-ATPase in the pulmonary epithelium.