gebhart/patrepeval huggingface dataset:
Evaluation of expression of cancer stem cell markers and fusion gene in synovial sarcoma: Insights into histogenesis and pathogenesis (2017)

Synovial sarcoma (SS) is an aggressive soft tissue tumor, with uncertain histological and cellular origin. SYT-SSX is considered to be responsible for sarcoma initiation and progression. The histogenesis and pathogenesis of this tumor are poorly understood, and prognosis of patients of SS is unsatisfactory. Recent studies have shown an association of cancer stem cells with the initiation and development of tumors. We explored immunohistochemical expression level of stem cell associated markers to determine the possible histogenesis and pathogenesis of SS. Fusion gene SYT-SSX was tested to assess diagnostic value and the molecular pathological features. We obtained the clinicopathological data of 20 SS patients, immunohistochemical staining were used to evaluate stem cell-associated markers included CD133, CD29, CD44, nestin, and ALDH1. Fusion gene SYT-SSX was tested by reverse transcriptase-polymerase chain reaction (RT-PCR). Twenty SS cases were observed and the positive immuno-expression results showed CD133 (17/20), CD29 (11/20), CD44 (11/20), nestin (6/20), and ALDH1 (5/20). Fusion gene SYT-SSX was successfully detected by RT-PCR from 18 available samples. The expression of stem cell-associated markers (CD133, CD29, CD44, Nestin, and ALDH1) and clinical data (age, gender, sites, tumor size, histological type, tumor stage, and distant metastases) did not show statistically significant relationship (P>0.05), whereas, statistically significance between ALDH1 and metastases was observed (P<0.01). The ALDH1 positive synovial sarcoma (ALDH1+ SS) cases had significantly poor prognosis compared to ALDH1 negative synovial sarcoma (ALDH1- SS) cases (P<0.05). Immunohistochemical results indicated different expression levels of the five cancer stem cell markers in SS suggesting that SS may arise from cancer stem cells. Fusion gene SYT-SSX may play a critical role in the molecular pathological of SS.
Data Analysis Techniques for a Lunar Surface Navigation System Testbed (2011)

NASA is interested in finding new methods of surface navigation to allow astronauts to navigate on the lunar surface. In support of the Vision for Space Exploration, the NASA Glenn Research Center developed the Lunar Extra-Vehicular Activity Crewmember Location Determination System and performed testing at the Desert Research and Technology Studies event in 2009. A significant amount of sensor data was recorded during nine tests performed with six test subjects. This paper provides the procedure, formulas, and techniques for data analysis, as well as commentary on applications.
High sensitivity vanadium–vanadium pentoxide–aluminium metal–insulator–metal diode (2018)

This work reports on the fabrication of an improved sensitivity metal–insulator–metal (MIM) diode. They devise an asymmetric structure diode that cascades vanadium, vanadium pentoxide, and aluminium (V–V 2 O 5 –Al) thin film layers. The MIM diode is fabricated using electron‐beam lithography, sputter deposition and metal liftoff techniques. X‐ray photoelectron spectroscopy analysis is performed to determine the phase composition of the V 2 O 5 insulating thin film. Electrical characterisation of the fabricated V–V 2 O 5 –Al shows a clear high sensitivity at −316 mV that reaches −8.52 V −1 with a dynamic resistance of 5.024 kΩ.
Focus on optimal health, not ideal health (2021)

Providers strive to help patients live the best, healthiest life they are capable of living. However, those efforts should involve a careful assessment of what the patient’s optimal health status is. It is deleterious to the therapeutic relationship to drive a patient towards a health status they are not able to attain. This article provides a brief commentary on the author’s experience as a patient to illustrate this point. Experience Framework This article is associated with the Patient, Family & Community Engagement lens of The Beryl Institute Experience Framework (https://www.theberylinstitute.org/ExperienceFramework). Access other PXJ articles related to this lens. Access other resources related to this lens.
CO2Multipliers in Multi-region Input-Output Models (2004)

In order to achieve equitable reduction targets, international trade has to be taken into account when assessing nations' responsibility for abating climate change. Especially for open economies such as Denmark, greenhouse gases embodied in internationally traded commodities can have a considerable influence on the national 'greenhouse gas responsibility'. We set up a five-region input-output model including Denmark, Germany, Sweden and Norway in order to calculate CO2 multipliers and trade balances. We investigate multidirectional feedback between these countries, and hence the error inherent in a single-region input-output model. We also examine the effect of aggregation on the model results. In the case of Denmark, an 11 Mt CO2 trade surplus resulting from a single-region model turns into balance when multidirectional trade is considered. Moreover, aggregated models are likely to result in significant errors. Therefore, both the type and the degree of aggregation used for modelling CO2 responsibilities could have a major bearing in international negotiations.
Use of the piezoelectric hydrophone for detecting infra-low-frequency seismoacoustic fields (2010)

A possibility of using piezoelectric sound detectors to record infra-low-frequency wave fields is demonstrated. A device for measuring seismoacoustic fields with frequencies 0.01 Hz and lower is developed. The bench tests of the hydrophone showed correctness of the technical approaches used.
Depletion of nucleophosmin leads to distortion of nucleolar and nuclear structures in HeLa cells (2008)

NPM (nucleophosmin; also known as B23) is an abundantly and ubiquitously expressed multifunctional nucleolar phosphoprotein, which is involved in numerous cellular processes, including ribosome biogenesis, protein chaperoning and centrosome duplication; however, the role of NPM in the cell cycle still remains unknown. In the present study, we show dynamic localization of NPM throughout the cell cycle of HeLa cells. Using a combination of RNAi (RNA interference) and three-dimensional microscopy we show that NPM is localized at the chromosome periphery during mitosis. We also demonstrate that depletion of NPM causes distortion of nucleolar structure as expected and leads to unexpected dramatic changes in nuclear morphology with multiple micronuclei formation. The defect in nuclear shape of NPM-depleted cells, which is clearly observed by live-cell imaging, is due to the distortion of cytoskeletal (alpha-tubulin and beta-actin) structure, resulting from the defects in centrosomal microtubule nucleation. These results indicate that NPM is an essential protein not only for the formation of normal nucleolar structure, but also for the maintenance of regular nuclear shape in HeLa cells.
TESTING VEHICLES WITH INDEPENDENT WHEELS ON THE FS (1984)

A series of studies has been carried out on the behaviour of independent wheels. The author of the article also carried out a series of tests in Italy to determine the behaviour of a bogie vehicle with independent wheels, which has many advantages over conventional vehicles.
Parallel‐plate waveguides with Kronig–Penney morphology as photonic band‐gap filters (2002)

Abstract Guided wave propagation in a parallel‐plate waveguide with Kronig–Penney morphology is analyzed. Modes in the photonic band‐gap (PBG) structure can be classified as either transverse electric or transverse magnetic with respect to the propagation direction. Above the modal cut‐off frequencies, band gaps exist where in propagation is forbidden. The locations and the widths of the band gaps depend on modal order, waveguide height, and the permittivity contrast and relative volumetric proportion of the two materials constituting the unit cell of the PBG structure. © 2002 Wiley Periodicals, Inc. Microwave Opt Technol Lett 36: 4–8, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.10654
The Distributed Bloom Filter (2019)

The Distributed Bloom Filter is a space-efficient, probabilistic data structure designed to perform more efficient set reconciliations in distributed systems. It guarantees eventual consistency of states between nodes in a system, while still keeping bloom filter sizes as compact as possible. The eventuality can be tweaked as desired, by tweaking the distributed bloom filter's parameters. The scalability, as well as accuracy of the data structure is made possible by combining two novel ideas: The first idea introduces a new, computationally inexpensive way for populating bloom filters, making it possible to quickly compute new bloom filters when interacting with peers. The second idea introduces the concept of unique bloom filter mappings between peers. By applying these two simple ideas, one can achieve incredibly bandwidth-efficient set reconciliation in networks. Instead of trying to minimize the false positive rate of a single bloom filter, we use the unique bloom filter mappings to increase the probability for an element to propagate through a network. We compare the standard bloom filter with the distributed bloom filter and show that even with a false positive rate of 50%, i.e. even with a very small bloom filter size, the distributed bloom filter still manages to reach complete set reconciliation across the network in a highly space-efficient, as well as time-efficient way.
GangES: Gang error simulation for hardware resiliency evaluation (2014)

As technology scales, the hardware reliability challenge affects a broad computing market, rendering traditional redundancy based solutions too expensive. Software anomaly based hardware error detection has emerged as a low cost reliability solution, but suffers from Silent Data Corruptions (SDCs). It is crucial to accurately evaluate SDC rates and identify SDC producing software locations to develop software-centric low-cost hardware resiliency solutions.
Optimizing Sulfide Shape Control in Large HSLA Steel Ingots by Treating the Melt with Calcium or Rare Earths (1978)

Solute segregation, constitution and distribution of sulfides in Ca-treated compared with RE-treated HSLA steel ingots have been investigated as a function of the concentration of Ca, RE, S and O. Characteristic S-segregation pattern including bottom cone sedimentation of sulfides is found to disappear at [%Ca] · [%S] 0.28≤1×10-3 in Ca-treated ingots and at [%RE] · [%S] ≤1×10-4 in RE-treated ingots. The disappearence is named “S-reversal”. These features are reasonably interpreted on the basis of the model proposed earlier to account for the “S-reversal” in RE-treated ingots.The degree of sulfide shape controlling with Ca or RE can favourably be evaluated in terms of atomic concentration ratio, ACR, of effective Ca or RE to S in the melt in mold. Sulfide shape control is in complete throughout the ingots at ACR of 0.2, satisfactory at 0.4 except for A- and V-segregates, then becomes complete even in the segregates at 1.8. By controlling the concentration of Ca or RE and S to fall within the area bound by ACR≥1.8 and [%Ca] · [%S] 0.28≤1×10-3 or [%RE] · [%S] ≤1×10-4 on Ca or RE vs S coordinates, HSLA steels that are totally free from hydrogen induced cracks have been produced for sour gas service.
Characteristics of Dysphagia in Severe Traumatic Brain Injury Patients: A Comparison With Stroke Patients (2016)

The swallowing characteristics of dysphagic patients after TBI were comparable to those of dysphagic stroke patients. Common VFSS findings comprised aspiration or penetration, decreased laryngeal elevation, and reduced epiglottis inversion. Patients who underwent surgical intervention after TBI were at high risk of tube feeding requirement.
Multi-pinhole collimator optimization for high resolution SPECT imaging (2002)

Recent studies show Tl-201 and Tc-99m MIBI to have high sensitivity for detecting and differentiating tumor from benign lesions in the breast. A study was conducted to optimize the design of a multi-pinhole collimator for high spatial resolution SPECT imaging of the breast to detect small tumors (0.5/spl times/0.5 cm). High sensitivity is achieved by using multiple pinholes, and rotating the camera 90-180 degrees around the breast. Monte Carlo simulation studies and analytical methods are applied to determine the number of holes, hole position, hole aperture size, conical field of view, and focal length of the collimator to optimize spatial resolution and sensitivity for breast imaging. Shielding is optimized to accommodate an energy range of 50-511 keV. An image reconstruction algorithm for cone beam imaging geometry for rotating single pinhole SPECT will be modified to accommodate simultaneous imaging from multiple pinholes with limited angular sampling. Special emphasis is placed on evaluation of imaging with small pinhole apertures (1-2 mm diameter), that are required to achieve the resolution of 3-7 mm at the distance of 10-15 cm with radionuclides having energies /spl les/140 keV. Complete 360/spl deg/ acquisition of the breast tumor model was simulated to study the artifacts in reconstructed images due to limited angle acquisition and to select an optimal reconstruction algorithm.
Synthesis, Structure, and Properties of BaAl2Si2 (2007)

Single crystals of BaAl2Si2 were grown from an Al molten flux and characterized using single-crystal X-ray diffraction at 10 and 90 K and neutron diffraction at room temperature. BaAl2Si2 crystallizes with the alpha-BaCu2S2 structure type (Pnma), is isostructural with alpha-BaAl2Ge2, and is an open 3D framework compound, where Al and Si form a covalent cagelike network with Ba2+ cations residing in the cages. BaAl2Si2 has a unit cell of a=10.070(3) A, b=4.234(1) A, and c=10.866(3) A, as determined by room-temperature single-crystal neutron diffraction (R1=0.0533, wR2=0.1034). The structure as determined by single-crystal neutron and X-ray diffraction (10 and 90 K) indicates that BaAl2Si2 (Pnma) is strictly isostructural to other (alpha)-BaCu2S2-type structures, requiring site specificity for Al and Si. Unlike BaAl2Ge2, no evidence for an alpha to beta (BaZn2P2-type, I4/mmm) phase transition was observed. This compound shows metallic electronic resistivity and Pauli paramagnetic behavior.
Dynamical Reorganization of Synchronous Activity Patterns in Prefrontal Cortex-Hippocampus Networks During Behavioral Sensitization (2013)

Neural synchrony exhibits temporal variability and, therefore, the temporal patterns of synchronization and desynchronization may have functional relevance. This study employs novel time-series analysis to explore how neural signals become transiently phase locked and unlocked in the theta frequency band in prefrontal cortex and hippocampus of awake, behaving rats during repeated injections of the psychostimulant, d-Amphetamine (AMPH). Short (but frequent) desynchronized events dominate synchronized dynamics in each of the animals we examined. After the first AMPH injection, only increases in the relative prevalence of short desynchronization episodes (but not in average synchrony strength) were significant. Throughout sensitization, both strength and the fine temporal structure of synchrony (measured as the relative prevalence of short desynchronizations) were similarly altered with AMPH injections, with each measure decreasing in the preinjection epoch and increasing after injection. Sensitization also induced decoupling between locomotor activity and synchrony. The increase in numerous short desynchronizations (as opposed to infrequent, but long desynchronizations) in AMPH-treated animals may indicate that synchrony is easy to form yet easy to break. These data yield a novel insight into how synchrony is dynamically altered in cortical networks by AMPH and identify neurophysiological changes that may be important to understand the behavioral pathologies of addiction.
Planning of Strength Margins Using Joint Modeling of Mean and Dispersion (2006)

Not only the strength of steel but also the variance of strength depends on composition and thermomechanical treatments. Information about the variance of strength is important when composition and thermomechanical treatments are planned to fulfill the strength requirements. In this work, heteroscedastic linear models were used for joint modeling of the mean and dispersion of strength. The models were used as tools in the optimization of the strength margins for steel plate products. The models were created by using industrial process data, and they were successfully used in a steel plate mill.
Animated exploration of dynamic graphs with radial layout (2005)

We describe a new animation technique for supporting interactive exploration of a graph. We use the well-known radial tree layout method, in which the view is determined by the selection of a focus node. Our main contribution is a method for animating the transition to a new layout when a new focus node is selected. In order to keep the transition easy to follow, the animation linearly interpolates the polar coordinates of the nodes, while enforcing ordering and orientation constraints. We apply this technique to visualizations of social networks and of the Gnutella file-sharing network, and discuss the results from our informal usability tests.
"Notre Kateri" : un regard féministe sur l'imagerie canadienne-française de la première sainte autochtone dans la première moitié du 20e siècle (2015)

Ce mémoire concerne l'iconographie de Kateri Tekakwitha (1656-1680), première sainte autochtone, produite au Québec lors de la première moitié du 20e siècle. Je vais décrire et évaluer la réception critique que lui a réservé l'histoire de l'art du Québec. Au même moment où apparaît un rayonnement d'images de la sainte, soit entre 1930 et 1960, les historiens de l'art portent presque exclusivement attention au premier portrait de Tekakwitha réalisé suite à sa mort par le jésuite Claude Chauchetière, seul portraitiste ayant connu la sainte de son vivant. À l'aide d'une intervention féministe postcoloniale/noire, je démontre que l'historiographie de cette œuvre est exemplaire d'une invisibilisation des expériences des femmes autochtones dans le contexte missionnaire du 17e siècle. Je rétablis ensuite l'iconographie de la sainte comme corpus dans l'histoire de l'art du Québec à partir d'une approche « visual studies » féministe qui priorise les enjeux identitaires tels que la production du stéréotype de la « princesse indienne », inséparable de l'hypothèse du processus « d'indigénisation » de la figure de Tekakwitha. Parmi les acteurs et actrices canadien-es-français-es qui ont participé à la création de cette iconographie, la présence de deux femmes autochtones qui ont joué le rôle de la sainte, Evelyn Montour et Cécile Jacobs, soulève les enjeux qui se manifestent lors de l'écriture de ce nouveau chapitre de l'histoire de l'art du Québec. Afin de ne pas reproduire la dynamique exclusive qui émerge de l'historiographie du premier portrait, je mobilise les approches qui portent sur l'agentivité du sujet représenté telles que développées par les historiennes de l'art Ruth B. Phillips et Charmaine Nelson.&#13;\n______________________________________________________________________________ &#13;\nMOTS-CLÉS DE L’AUTEUR : Kateri Tekakwita (1656-1680), Visual studies, Féminisme, Représentation, Histoire de l'art du Québec, Autochtone
Captive Medical Insurance Schemes using UK Trusts (1995)

Journal Article Captive Medical Insurance Schemes using UK Trusts Get access Dudley Lusted, Dudley Lusted Director Medisure Division, Sedgwick Noble Lowndes Healthcare LimitedSedgwick House, The Sedgwick Centre, London E1 8DX, Tel: +44 (0) 171 377 3456, Fax: +44 (0) 171 377 3199 Search for other works by this author on: Oxford Academic Google Scholar Andrew Tunnicliffe Andrew Tunnicliffe Associate Director Sedgwick Management Services (London) LtdSedgwick House, The Sedgwick Centre, London E1 8DX, Tel: +44 (0) 171 377 3456, Fax: +44 (0) 171 377 3199 Search for other works by this author on: Oxford Academic Google Scholar Trusts & Trustees, Volume 1, Issue 2, January 1995, Pages 32–33, https://doi.org/10.1093/tandt/1.2.32 Published: 01 January 1995
Generalizability of the Type A/Type B Distinction Across Different Psychoactive Substances (1996)

Previous research using cluster analysis has found that abusers of both alcohol and cocaine can be categorized into more severe (Type B) and less severe (Type A) subgroups. This article sought to replicate and extend these findings in a sample of 521 inpatients, outpatients, and nontreatment-seeking abusers of alcohol, cocaine, marijuana, and opiates. Cluster analyses of subsamples that met the DSM-IV criteria for dependence or abuse for alcohol, cocaine, marijuana, and opiates found that the Type A/Type B distinction was largely generalizable across drugs. Type As--who consistently accounted for about 60% of all substance abuse and about half of abusers in treatment-scored lower than Type Bs on a variety of substance abuse and psychiatric measures that were administered both at intake and at a 6-month follow-up.
Cover Image, Volume 74, Issue 2 (2018)

The cover image, by Chenxi Wu et al., is based on the Research Article Limited fitness costs of herbicide‐resistance traits in Amaranthus tuberculatus facilitate resistance evolution , DOI: 10.1002/ps.4706 . Photo Credit: Chenxi Wu. image
Serum Immunoglobulin Levels in Humans Exposed to Therapeutic Total-Body Gamma Irradiation (1975)

Stuart Chaskes, G. Charles Kingdon, Edward Balish, Serum Immunoglobulin Levels in Humans Exposed to Therapeutic Total-Body Gamma Irradiation, Radiation Research, Vol. 62, No. 1 (Apr., 1975), pp. 145-158
Interleukin-6 Receptor Signalling and Abdominal Aortic Aneurysm Growth Rates (2018)

Abstract Background The Asp358Ala variant (rs2228145; A&gt;C) in the interleukin-6 receptor ( IL6R ) gene has been implicated in the development of abdominal aortic aneurysms (AAAs), but its effect on AAA growth over time is not known. We aimed to investigate the clinical association between the IL6R -Asp358Ala variant and AAA growth, and to assess the effect of blocking the IL-6 signalling pathway in mouse models of aneurysm rupture. Method Using data from 2,863 participants with AAA from nine prospective cohorts, age- and sex-adjusted mixed-effects linear regression models were used to estimate the association between the IL6R -Asp358Ala variant and annual change in AAA diameter (mm/year). In a series of complementary randomised trials in mice, the effect of blocking the IL-6 signalling pathways was assessed on plasma biomarkers, systolic blood pressure, aneurysm diameter and time to aortic rupture and death. Results After adjusting for age and sex, baseline aneurysm size was 0.55mm (95% confidence interval [CI]: 0.13, 0.98mm) smaller per copy of the minor allele [C] of the Asp358Ala variant. There was no evidence of a reduction in AAA growth rate (change in growth=-0.06mm per year [−0.18, 0.06] per copy of the minor allele). In two mouse models of AAA, selective blockage of the IL-6 trans-signalling pathway, but not combined blockage of both, the classical and trans-signalling pathways, was associated with improved survival (p&lt;0.05). Conclusions Our proof-of-principle data are compatible with the concept that IL-6 trans-signalling is relevant to AAA growth, encouraging larger-scale evaluation of this hypothesis.