gebhart/patrepeval huggingface dataset:
Turnover of hexitols in the marine macroalgaHimanthalia elongata(Phaeophyta, Fucales) (1995)

13C nuclear magnetic resonance spectroscopy (NMR) has been used to study the metabolic flux of carbon through the intracellular pools of the isomeric hexitols d-altritol and d-mannitol in Himanthalia elongata. Natural abundance 13C NMR spectra of freshly collected plant material showed altritol as the dominant intracellular low-molecular-weight organic solute, with mannitol present at less than 20% of the altritol concentration. Plant material incubated in seawater medium with added 13C-enriched bicarbonate showed a rapid increase in the 13C signal due to mannitol, with an increase of more than 12-fold in under 48 h, in contrast to the altritol signal, which increased by approximately 2-fold over the same period. The intracellular mannitol signal decreased rapidly when 13C-enriched plant material was transferred to a non-enriched medium, while altritol showed a slower decline. These results are consistent with previous observations on the effects of salinity on the intracellular hexitol pools of H. elongata, suggesting that mannitol is more rapidly metabolised than altritol. Estimates of the half-time for tracer exchange support this view, with a half-time for the turnover of altritol (> 400 h) which is an order of magnitude greater than that for mannitol turnover (≈ 50h).
Mid-infrared Transmission Properties of Step index and Large Mode Area ZnSe Microstructured Optical Fibers (2012)

ZnSe microstructured fibers have been designed and fabricated using silica capillaries and an air-silica photonic band-gap optical fiber as high-pressure microfluidic templates for semiconductor growth via chemical fluid deposition. We examine their transmission properties over a wide spectral range.
Acute efficacy, safety, and long-term clinical outcomes using the second-generation cryoballoon for pulmonary vein isolation in patients with a left common pulmonary vein: A multicenter study (2017)

Patients with an LCPV undergoing CB2-based PVI demonstrate a high acute success rate. Comparable results with regard to clinical success and durability of PVI were shown when comparing patients of the LCPV group and the control group.
Set-Dueling-Controlled Adaptive Insertion for High-Performance Caching (2008)

The commonly used LRU replacement policy causes thrashing for memory- intensive workloads. A simple mechanism that dynamically changes the insertion policy used by LRU replacement reduces cache misses by 21 percent and requires a total storage overhead of less than 2 bytes.
Biological and clinical developments in melanoma vaccines (2001)

The identification of antigens recognised on human tumours by autologous T-lymphocytes has opened the way for vaccination strategies involving defined tumour antigens. These vaccinations are therapeutic, i.e. they involve patients with detectable disease. Tumour regressions have been observed in a minority of melanoma patients in Phase I/II trials. Some of these regressions have been complete and long lasting. Improving the efficacy of therapeutic vaccines will critically depend on their capacity to trigger a robust immune response, on the development of appropriate methods to monitor these antitumour immune responses to vaccination and on a better understanding of the mechanisms used by tumours to escape immune attack. Finally, the initiation of large randomised Phase III trials will determine the impact of these vaccines on melanoma treatment.
A Sub-1-V 65-nm MOS Threshold Monitoring-Based Voltage Reference (2014)

This brief presents a sub-1-V 65-nm MOS threshold voltage monitoring-based voltage reference (V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TH</sub> sensor) with current-mode second-order temperature compensation. By utilizing the different temperature properties of P+ diffusion and poly resistors, auxiliary nonlinear temperature compensation is implemented in the Brokaw MOS V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TH</sub> circuit. By doing so, it attenuates the nonlinear temperature effect of gate-to-source voltage (V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">GS</sub> ), thus lowering the temperature coefficient (T.C.). Fabricated in a UMC 65-nm CMOS process, the results show that the circuit can generate an average reference voltage of 474 mV. This is close to the extrapolated V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TH</sub> for a low-threshold nMOS transistor at absolute zero temperature. In a range from -40 °C to 90 °C, the best T.C. achieved by the circuit is 24.5 ppm/°C and the average T.C. over 15 samples is 40 ppm/°C.
Ethnic Differences in Response to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors (2006)

The identification of somatic mutations in the tyrosine kinase domain of the epidermal growth factor receptor (EGFR) in non-small-cell lung cancer (NSCLC) and their correlation with response to EGFR inhibitors has become an important event in the fields of cancer genetics and therapeutics. The initial observation of a higher response to gefitinib and erlotinib in patients of Asian origin was followed by the discovery that they harbor more frequent EGFR mutations in NSCLC; this raises the issue of ethnic diversity in the pathogenesis of given tumors. In a similar fashion, amplification of the closely related HER2 gene, which could also have implications for the treatment of NSCLC, is also more frequent in East Asian patients. On the other hand, EGFR gene amplification may be more prevalent in Western populations. The implication of these findings is that ethnicity may indicate different genetic backgrounds in common tumors that may influence clinical outcome and response to therapy. Therefore, in clinical trials with tyrosine kinase inhibitors and other molecular-targeted therapies, the inclusion of a global population appears to be required.
Faculty Opinions recommendation of High-Frequency Biomarker Measurements of Troponin, NT-proBNP, and C-Reactive Protein for Prediction of New Coronary Events After Acute Coronary Syndrome. (2021)

Read the full review for this Faculty Opinions recommended article: High-Frequency Biomarker Measurements of Troponin, NT-proBNP, and C-Reactive Protein for Prediction of New Coronary Events After Acute Coronary Syndrome.
Intermittency and Chaos in Monte-Carlo Based Simulations of Low Temperature Impurity Breakdown (1992)

International audience
Transcatheter closure of large pulmonary arteriovenous fistula including pulmonary artery to left atrial fistula with Amplatzer septal occluder (2007)

We conclude that, using the new criteria for device size selection and modified technique of implantation, very large PAVFs including PA to LA fistula can be closed safely, effectively and nonsurgically with ASO.
Efficient Numerical Analysis of a Periodic Structure of Multistate Unit Cells (2014)

Application of the synthetic function expansion (SFX) algorithm to the analysis of active 1- and 2D periodic structures is presented. The single unit cell consisting of a microstrip line loaded by patches positioned below the line is turned into an active structure by inserting a pair of 2 switches to the two ends of each patch; the states of the pair of switches are changed contemporaneously. Variation of the states of the switches modifies the current distribution on the structure. The tunable multistate unit cell is arranged in 24-, 120-, and 9 × 24 element configurations and numerically analyzed. The computational complexity required for the characterization of the large number of possible configurations is lightened by the use of the proposed numerical method.
Contributions of sibling relations to the adaptation of youths with insulin-dependent diabetes mellitus. (1992)

Associations among sibling relations and the psychosocial and illness-specific adaptation of youths (N = 66) with insulin-dependent diabetes mellitus (IDDM) were examined. The findings suggest that sibling relations, especially sibling conflict, contribute an independent source of variance above and beyond that contributed by demographic characteristics, sibling constellation variables, and important dimensions of family relations in predicting the youths' adaptation. High family-life stress and high sibling status/power contributed unique variance in predicting internalizing behaviors, and male gender and sibling conflict contributed independently to externalizing problems. Sibling conflict also contributed unique variance to the youth's general self-esteem, along with social class and family cohesion, and to their adjustment to IDDM. Data suggest that parent-child dyads and sibling dyads represent interrelated and independent subsystems within the family, and that both subsystems may influence the psychosocial functioning of youths with IDDM.
Whole-track imaging and diagnostics of hard disk data using the spin-stand imaging technique (2005)

The spin-stand imaging technique is further developed for the imaging and diagnostics of whole-track hard disk data from off-centered disks. It is shown that the hard disk tracks are nearly sinusoidally modulated in the radial direction due to eccentricity. Special centering algorithms have been devised that successfully demodulated the imaged tracks.
Tau Accumulation in Primary Motor Cortex of Variant Alzheimer’s Disease with Spastic Paraparesis (2016)

We studied topographic distribution of tau and amyloid-β in a patient with variant Alzheimer's disease with spastic paraparesis (VarAD) by comparing AD patients. The proband developed progressive memory impairment, dysarthria, and spastic paraparesis at age 23. Heterozygous missense mutation (L166P) was found in exon 6 of presenilin-1 gene. The proband showed prominently increased amyloid binding in striatum and cerebellum and asymmetrical tau binding in the primary sensorimotor cortex contralateral to the side more affected by spasticity. We suspect that upper motor neuron dysfunctions may be attributed to excessive abnormal tau accumulation rather than amyloid-β in the primary motor cortex.
La dissemination de bacillus thuringiensis dans l'environnement : conjugaison et persistance de la bacterie genetiquement modifiee et resistance du spodoptera littoralis boisduval a la toxine cryic (1995)

Cette etude a ete conduite selon trois axes complementaires: l'effet de la toxine de bacillus thuringiensis sur l'insecte spodoptera littoralis, la survie des souches sous conditions de microcosme, le transfert de l'adn intraspecifique des souches de b. Thuringiensis dans des microcosmes differents et dans des conditions naturelles en plein champ. La toxine cryic a ete exprimee dans une souche cristal moins de b. Thuringiensis qui a ete utilisee pour selectionner une lignee de s. Littoralis resistante a cette toxine. L'insecte a developpe une resistance a 500 fois a cryic, et a montre des resistances croisees aux toxines cryid et cryie mais aucune resistance a la toxine cryif. La sex ration et la fecondite de la lignee resistante ne sont pas differentes de la lignee sensible, mais la fertilite est augmentee. Ces etudes genetiques ont montre que la resistance a cryic est un trait co-recessif. Des souches de b. Thuringiensis ont ete marquees pour creer une souche donneuse, hd73-ii'lacz et une souche receptrice, ia91. La souche donneuse a ete marquee par le gene du lacz sur un plasmide conjugatif, qui est tres stable sur milieu artificiel, dans les sols en microcosme et en plein champ. La souche receptrice a ete marquee par selection avec la streptomycin, et localisee sur le chromosome. La conjugaison entre les deux souches est de haute frequence en milieu artificiel, et peut se produire chez les insectes sensibles ou dans les conditions du microcosme ideal
Marker Removal System for Thermoanaerobacterium saccharolyticum and Development of a Markerless Ethanologen (2011)

Marker removal strategies were developed for Thermoanaerobacterium saccharolyticum to select against the pyrF gene and the pta and ack genes. The pta- and ack-based haloacetate selective strategy was subsequently used to create strain M0355, a markerless Δldh Δpta Δack strain that produces ethanol at a high yield.
Handbook of nonwovens (2007)

Development of the Nonwoven Industry. Dry-Laid Web Formation. Wet-Laid Formation. Polymer-Laid Web Formation. Mechanical Bonding. Thermal Bonding. Chemical Bonding. Chemical and Mechanical Finishing. Characteristics, Testing, and Modelling of Nonwoven Fabrics.
Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice (2019)

Vaccines are a 20th century medical marvel. They have dramatically reduced the morbidity and mortality caused by infectious diseases and contributed to a striking increase in life expectancy around the globe. Nonetheless, determining vaccine efficacy remains a challenge. Emerging evidence suggests that the current acellular vaccine (aPV) for Bordetella pertussis (B. pertussis) induces suboptimal immunity. Therefore, a major challenge is designing a next-generation vaccine that induces protective immunity without the adverse side effects of a whole-cell vaccine (wPV). Here we describe a protocol that we used to test the efficacy of a promising, novel adjuvant that skews immune responses to a protective Th1/Th17 phenotype and promotes a better clearance of a B. pertussis challenge from the murine respiratory tract. This article describes the protocol for mouse immunization, bacterial inoculation, tissue harvesting, and analysis of immune responses. Using this method, within our model, we have successfully elucidated crucial mechanisms elicited by a promising, next-generation acellular pertussis vaccine. This method can be applied to any infectious disease model in order to determine vaccine efficacy.
Live cell refractometry using microfluidic devices (2006)

Using Hilbert phase microscopy for extracting quantitative phase images, we measured the average refractive index associated with live cells in culture. In order to decouple the contributions to the phase signal of the cell refractive index and thickness, we confined the cells in microchannels.
Author Correction: Mapping mesoscopic phase evolution during E-beam induced transformations via deep learning of atomically resolved images (2018)

In the original version of this Article the term ‘rhombohedral’ was used incorrectly in place of ‘oblique’, and the term ‘rhombohedral’ was used in Supplementary Figure 5 to describe the simulated lattice but we had instead simulated a rectangular centered lattice. All mentions of ‘rhombohedral’ have been corrected to ‘oblique’ in the manuscript, Fig. 2 and Fig. 4–6, and Supplementary Information. Similarly, ‘centered rectangle’ has been corrected to ‘rectangular centered lattice’ throughout the manuscript to avoid any confusion in terminology. Supplementary Figure 5 was not accurately computed in the original published version, and has now been recomputed to meet the actual definition of an oblique Bravais lattice. There was also a typographical error in the original version of the Article, where Fig. 3c was referred to instead of Fig. 3d on page 4 of the manuscript. The above changes have been made to the HTML and PDF versions of the Article. These errors were alerted to the authors by Prof. M. Nespolo (Université de Lorraine) and Prof. P. Moeck (Portland State University), to whom we are grateful.
Pan PPAR agonist IVA337 is effective in prevention and treatment of experimental skin fibrosis (2016)

These findings indicate that simultaneous activation of all three PPAR isoforms exerts a dampening effect on inflammation and fibrosis, making IVA337 a potentially effective therapeutic candidate in the treatment of fibrotic diseases including SSc.
Optimization of Li-Ion battery Electrodes: A Numerical Study (2008)

Abstract not Available.
Fast battery equalization with isolated bidirectional DC-DC converter for PHEV applications (2009)

Battery systems in plug-in hybrid electric vehicles (PHEV) suffer from voltage imbalance. This imbalance reduces the available capacity of certain charge/discharge cycles and shortens the battery life cycle. A new topology and smart balancing strategy for PHEV battery systems are proposed in this paper, which uses a bidirectional DC-DC converter to reduce balancing time and the number of switches needed. The simulation on a ten series connected battery cell is compared to a traditional switched capacitor equalizer.
The path forward: 2015 International Children's Tumor Foundation conference on neurofibromatosis type 1, type 2, and schwannomatosis (2017)

The Annual Children's Tumor Foundation International Neurofibromatosis Meeting is the premier venue for connecting discovery, translational and clinical scientists who are focused on neurofibromatosis types 1 and 2 (NF1 and NF2) and schwannomatosis (SWN). The meeting also features rare tumors such as glioma, meningioma, sarcoma, and neuroblastoma that occur both within these syndromes and spontaneously; associated with somatic mutations in NF1, NF2, and SWN. The meeting addresses both state of the field for current clinical care as well as emerging preclinical models fueling discovery of new therapeutic targets and discovery science initiatives investigating mechanisms of tumorigenesis. Importantly, this conference is a forum for presenting work in progress and bringing together all stakeholders in the scientific community. A highlight of the conference was the involvement of scientists from the pharmaceutical industry who presented growing efforts for rare disease therapeutic development in general and specifically, in pediatric patients with rare tumor syndromes. Another highlight was the focus on new investigators who presented new data about biomarker discovery, tumor pathogenesis, and diagnostic tools for NF1, NF2, and SWN. This report summarizes the themes of the meeting and a synthesis of the scientific discoveries presented at the conference in order to make the larger research community aware of progress in the neurofibromatoses.
Inclusion Compound Formed between Poly(L-lactic acid) and Urea (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInclusion Compound Formed between Poly(L-lactic acid) and UreaC. Howe, N. Vasanthan, C. MacClamrock, S. Sankar, I. D. Shin, I. K. Simonsen, and A. E. TonelliCite this: Macromolecules 1994, 27, 25, 7433–7436Publication Date (Print):December 1, 1994Publication History Published online1 May 2002Published inissue 1 December 1994https://pubs.acs.org/doi/10.1021/ma00103a028https://doi.org/10.1021/ma00103a028research-articleACS PublicationsRequest reuse permissionsArticle Views302Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Phosphatidylinositol 3-Kinase-C2β Inhibits Cisplatin-Mediated Apoptosis via the Akt Pathway in Oesophageal Squamous Cell Carcinoma (2011)

A major problem in treating oesophageal squamous cell carcinoma (ESCC) with cisplatin is the development of drug resistance. In order to determine whether phosphatidylinositol 3-kinase (PI3K)-C2β (encoded by the PIK3C2B gene) reduced the sensitivity of ESCC to cisplatin, transfected Eca109 cells that overexpressed PIK3C2B were produced. Additionally, PI3K-C2β-siRNA was used to silence endogenous PI3K-C2β in EC9706 cisplatin-resistant cells. The relationship between PIK3C2B expression and clinicopathological characteristics was also investigated in samples from 61 patients. The overexpression of PIK3C2B in Eca109 cells significantly inhibited cisplatin-induced apoptosis and cleavage of caspase-3. Knockdown of PI3K-C2β enhanced cisplatin-induced apoptosis in EC9706 cells. PIK3C2B expression was associated with an increased level of phosphorylated Akt. Based on the tumour samples, expression of PIK3C2B was associated with tumour metastasis and in vitro assay suggested that it mediated cell migration. These results indicated that PI3K-C2β, via the Akt signalling pathway, might play a key role in cisplatin resistance and that targeting this pathway might be useful in treating cisplatin-resistant tumours.
Modeling and Deploying Networklet (2017)

The lines between IaaS, PaaS, and SaaS are becoming blurred as datacenter providers seek to create cloud platforms that can widen their appeal to developers. With this kind of hybrid datacenter, resource requests from tenants are increasingly transforming into hybrid requests that may simultaneously demand IaaS, PaaS, and SaaS resources. This paper tackles the challenge of modeling and deploying hybrid tenant requests in datacenter networks, for which we coin ``networklet" to represent a set of VMs that collaboratively provide some PaaS or SaaS service. Through extracting networklets from tenant requests and thus sharing them between multiple tenants, we can achieve a win-win situation for datacenter providers and tenants. Extensive evaluations show that, the proposed model and deployment algorithm indeed improve DCN resource utilization while maintaining performance guarantee.