gebhart/patrepeval huggingface dataset:
Mechanical Damage Propagation in Polymer Electrolyte Membrane Fuel Cells (2012)

While significant advances in polymer electrolyte membrane fuel cell (PEMFC) technology have taken place in the past decade, challenges still remain in the area of mechanical degradations [1]. Mechanical degradations and damage in PEMFCs including cracks and failure in the membrane electrode assembly (MEA) [2–5] can lead directly to fuel crossover, performance degradation, and reduced durability. It is therefore critical to identify and control the mechanisms that can contribute to damage initiation and propagation in the PEMFC. In this work, we investigate the damage propagation in the MEA, with a special focus on the gas diffusion layer (GDL)/catalyst layer (CL) and the membrane/CL interfaces. A numerical cohesive constitutive model is developed to explore the effect of geometry, the material properties of each component, and the location of the delamination on the propagation behaviour of through-plane delaminations.
Comment on “Laser-like mechanoluminescence in ZnMnTe-diluted magnetic semiconductor” [Appl. Phys. Lett. 81, 460 (2002)] (2003)

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Contracts in Offshore Software Development: An Empirical Analysis (2003)

We study the determinants of contract choice in offshore software development projects and examine how the choice of contract and other factors in the project affect project profits accruing to the software vendor. Using data collected on 93 offshore projects from a leading Indian software vendor, we provide evidence that specific vendor-, client-, and project-related characteristics such as requirement uncertainty, project team size, and resource shortage significantly explain contract choice in these projects. Our analysis suggests that contract choice significantly determines project profit. Additionally, some ex ante vendor-, client-, and project-related characteristics known at the time of choosing the contract continue to significantly influence project profits after controlling for contract choice. We also provide evidence to show that project duration and team size affect project profits.
Preferential Siting of Aluminum Heteroatoms in the Zeolite Catalyst Al‐SSZ‐70 (2019)

The adsorption and reaction properties of heterogeneous zeolite catalysts (e.g. for catalytic cracking of petroleum, partial oxidation of natural gas) depend strongly on the types and distributions of Al heteroatoms in the aluminosilicate frameworks. The origins of these properties have been challenging to discern, owing in part to the structural complexity of aluminosilicate zeolites. Herein, combined solid-state NMR and synchrotron X-ray powder diffraction analyses show the Al atoms locate preferentially in certain framework sites in the zeolite catalyst Al-SSZ-70. Through-covalent-bond 2D <sup>27</sup> Al{<sup>29</sup> Si} J-correlation NMR spectra allow distinct framework Al sites to be identified and their relative occupancies quantified. The analyses show that 94 % of the Al atoms are located at the surfaces of the large-pore interlayer channels of Al-SSZ-70, while only 6 % are in the sub-nm intralayer channels. The selective siting of Al atoms accounts for the reaction properties of catalysts derived from SSZ-70.
Characteristic evaluation of pencil-drawn carbon electrode by potassium and sodium ion selectivity measurement and energy-dispersive X-ray spectroscopy (2020)

Abstract This paper explains the ion-sensing mechanism and selectivity evaluation of the pencil-drawn carbon electrode (PCE) employed as a pH electrode in the authors’ previous report. The elemental composition of the PCE was found to be C, O, Si, Al, and Na by energy-dispersive X-ray spectroscopy (EDX). The carbon is regarded as the graphite performing electrical conduction, while the other elements formed clay as an ion exchanger. Furthermore, the potential responses to K + and Na + were measured, and the selectivity is discussed quantitatively under the Eisenman equation which describes the ion exchanger potential with cation interference. The selectivity coefficients were estimated to be 10 −4.10 to 10 −3.87 and 10 −5.00 to 10 −4.89 for K + and Na + with n of 4 to 5, respectively. The EDX analysis and selectivity measurement show that the PCE might have ion exchange properties similar to those of a glass electrode and it sufficiently behaves as a pH electrode in wide targets having only slightly interfering cations.
Transient Upregulation of Postsynaptic IP3-Gated Ca Release Underlies Short-Term Potentiation of Metabotropic Glutamate Receptor 1 Signaling in Cerebellar Purkinje Cells (2008)

Synaptic plasticity lasting approximately 100 s has been suggested to function as a temporary buffer for neural information. One example of this was reported by Batchelor and Garthwaite (1997), who found that a slow metabotropic glutamate receptor 1 (mGluR1)-evoked EPSP produced by burst stimulation of cerebellar parallel fiber-Purkinje cell synapses could be potentiated by a conditioning stimulus consisting of prior activation of climbing fiber synapses (or injection of depolarizing current) with a delay of up to 90 s. What is the molecular basis of the signal that spans this temporal gap? Here, we show that mGluR1-evoked slow EPSCs evoked by parallel fiber burst test stimuli show a similar form of short-term potentiation (mGluR1-STP) and that this phenomenon is also observed when parallel fiber bursts are replaced by pressure pulses of an exogenous mGluR1 agonist. Ca imaging experiments revealed that cytosolic Ca levels returned to baseline within several seconds after conditioning depolarization, indicating that this cannot underlie mGluR1-STP. To test the hypothesis that transient upregulation of inositol-1,4,5-trisphosphate (IP(3))-gated Ca release underlies this phenomenon, we used local photolytic uncaging of IP(3) to deplete IP(3)-gated Ca stores. IP(3) uncaging in the interval between conditioning depolarization and the test pulse produced a complete blockade of mGluR1-STP, as did blockade of IP(3) receptors with heparin. When Ca transients evoked by IP(3) uncaging were used as a test stimulus, conditioning depolarization produced a large STP of Ca response amplitudes. These data suggest that transient upregulation of postsynaptic IP(3)-gated Ca signaling constitutes a novel form of short-term synaptic plasticity.
Anisotropic Solitons in Dipolar Bose-Einstein Condensates (2008)

Starting with a Gaussian variational ansatz, we predict anisotropic bright solitons in quasi-2D Bose-Einstein condensates consisting of atoms with dipole moments polarized perpendicular to the confinement direction. Unlike isotropic solitons predicted for the moments aligned with the confinement axis [Phys. Rev. Lett. 95, 200404 (2005)10.1103/PhysRevLett.95.200404], no sign reversal of the dipole-dipole interaction is necessary to support the solitons. Direct 3D simulations confirm their stability.
Roof Damage Patterns and Serious Head Injuries in Pure Rollover Crashes (2014)

This study evaluated the association between the pattern of roof damage resulting from a pure rollover crash and the incidence of serious head injuries (SHIs) for contained, restrained occupants. As part of a larger project with the goal of developing a dynamic crash test protocol for rollover occupant protection, these associations will help to define the initial conditions of a rollover test that produce the damage patterns that are most likely to result in SHI. Pure rollover crashes from the U.S. National Automotive Sampling System's Crashworthiness Data System were used in the study. The roof damage pattern above the seat position of each occupant in the data set was identified by the photographs included in each case file and coded to one of eight specified patterns; 1,151 cases in which the damage pattern could be determined for a relevant rollover occupant were identified. SHIs were observed only for cases with evidence of a roof-to-ground impact. Although the results indicated that this pattern of roof damage was associated with the occurrence of SHI, the pattern was rarely more significant than other crash outcome parameters.
Advances in Deep Learning Techniques for Medical Image Analysis (2018)

Deep learning is contributing to the high level of services to the healthcare sector. As the digital medical data is increasing exponentially with time, early detection and prediction of diseases are becoming more efficient because of the deep learning techniques which reduce the fatality rate to a great extent. The main focus of this paper is to provide the comprehensive review of deep learning in the domain of medical image processing and analysis. We have demonstrated the use of new deep learning architectures in oncology for the prediction of different types of cancer like the brain, lung, skin, etc. The state-of-the-art architectures effectively carry out analysis of 2D and 3D medical images to make the diagnosis of patients faster and more accurate. The use of popular approaches in machine learning such as ensemble and transfer learning with fine-tuning of parameters improve the performance of the deep neural networks in medical image analysis. The existing deep networks urge the new image classification network called Capsule Network (CapsNet) to make the classification and detection comparatively better. The equivariance characteristics of CapsNet make it more influential as it discourages the effect of any structural invariance of an input image on the network.
Identification of new heading date determinants in wheat 5B chromosome (2016)

We supposed that the difference in activity of WRKY, ERF/AP2 and/or FHY3/FAR1 transcription factors between CS and CS-5Bdic to be a probable reason for the observed difference in heading dates. Data obtained in this study provide a good basis for the subsequent investigation of heading time pathways in wheat.
A Novel Mechanism of Tissue Inhibitor of Metalloproteinases-1 Activation by Interleukin-1 in Primary Human Astrocytes (2021)

Reactive astrogliosis is the gliotic response to brain injury with activated astrocytes and microglia being the major effector cells. These cells secrete inflammatory cytokines, proteinases, and proteinase inhibitors that influence extracellular matrix (ECM) remodeling. In astrocytes, the expression of tissue inhibitor of metalloproteinases-1 (TIMP-1) is up-regulated by interleukin-1 (IL-1), which is a major neuroinflammatory cytokine. We report that IL-1 activates TIMP-1 expression via both the IKK/NF-kappaB and MEK3/6/p38/ATF-2 pathways in astrocytes. The activation of the TIMP-1 gene can be blocked by using pharmacological inhibitors, including BAY11-7082 and SB202190, overexpression of the dominant-negative inhibitor of NF-kappaB (IkappaBalphaSR), or by the knock-down of p65 subunit of NF-kappaB. Binding of activated NF-kappaB (p50/p65 heterodimer) and ATF-2 (homodimer) to two novel regulatory elements located -2.7 and -2.2 kb upstream of the TIMP-1 transcription start site, respectively, is required for full IL-1-responsiveness. Mutational analysis of these regulatory elements and their weak activity when linked to the minimal tk promoter suggest that cooperative binding is required to activate transcription. In contrast to astrocytes, we observed that TIMP-1 is expressed at lower levels in gliomas and is not regulated by IL-1. We provide evidence that the lack of TIMP-1 activation in gliomas results from either dysfunctional IKK/NF-kappaB or MEK3/6/p38/ATF-2 activation by IL-1. In summary, we propose a novel mechanism of TIMP-1 regulation, which ensures an increased supply of the inhibitor after brain injury, and limits ECM degradation. This mechanism does not function in gliomas, and may in part explain the increased invasiveness of glioma cells.
Fluid Velocity Measurements in Electro-Vortical Flows (2004)

Abstract This class of flows is characterized by the feeding of strong electrical currents into a volume of liquid metal. A prominent example of industrial interest is electrode-welding, where the current is supplied via a locally restricted area, leading to high current densities. The interaction of these currents with their own magnetic field drives flows that exhibit phenomena such as formation of jets and the pinch effect. Further increasing the current may lead to disruption of the melt column accompanied by a discharge. This can be used for a liquid metal current limiter with self-healing properties. Local measurements of the flow structures are of obvious interest for a better understanding of these phenomena. This paper will give results from a systematic study of the flow structure performed by means of our mechano-optical velocity probe. The measured flow structure of the evolving jet was found to be in reasonable agreement with our numerical simulations.
Early left atrial dysfunction is associated with suboptimal cardiovascular health (2019)

LASs during the reservoir phase was diminished in subjects with a lower level of CVH. Higher insulin, HOMA, total cholesterol, glycemia, and BMI values were associated with decreased LA deformation during the reservoir phase. Morphofunctional alterations of the LA were also identified in the group with suboptimal CVH, as well as BP values in the range of hypertension. LA dysfunction in an asymptomatic population, along with metabolic syndrome, could be an early event in the continuum of CV damage.
Direct Tensile Tests of Individual WS<sub>2</sub> Nanotubes (2005)

The Young’s modulus of WS2 nanotubes is an important property for various applications. Measurements of the mechanical properties of individual nanotubes are challenging because of the small size of the tubes. Lately, measurements of the Young’s modulus by buckling of an individual nanotube using an atomic force microscope1 resulted in an average value of 171GPa. Tensile tests of individual WS2 nanotubes were performed experimentally using a scanning electron microscope and simulated tensile tests of MoS2 nanotubes were performed by means of a densityfunctional tight-binding (DFTB) based molecular dynamics (MD) scheme. Preliminary results for WS2 nanotubes show Young’s modulus value of ca.162GPa, tensile strength value of ca. 13GPa and average elongation of ca. 12%. MD simulations resulted in elongation of 19% for zigzag and 17% for armchair MoS2 single wall nanotubes. Since MoS2 and WS2 nanotubes have similar structures the same behavior is expected for both, hence there is a good agreement regarding the elongation of WS2 nanotubes between experiment and simulation.
Amphetamine‐associated seizures: Clinical features and prognosis (2011)

Forty-four patients presenting with first-ever seizure within 24 h of illicit use of amphetamine or related analogs (amphetamine-associated seizures, AAS) were identified over 8 years. Patients with AAS were compared to control groups of other first-ever seizure patients (provoked n = 126 and unprovoked n = 401). Cumulative probability of recurrence was calculated using Kaplan-Meier analysis. Seizure recurrence and development of epilepsy were less likely in patients with AAS compared to provoked or unprovoked controls. Forty percent of patients with AAS had clinical risk factors for epilepsy, epileptiform abnormalities on electroencephalography (EEG), or an epileptogenic lesion on neuroimaging. Sleep deprivation was more frequently present in those with AAS. AAS likely relate to an intrinsic proconvulsant effect of these drugs combined with patient susceptibility and environmental factors.
Extremely High-Rate, Uniform Dissolution of Alloy 22 in Anhydrous Organic Solutions at Room Temperature (2016)

During routine pharmaceutical development and scale-up work, severe corrosion of a Hastelloy Alloy C-22 (Alloy 22) filter dryer was observed after single, short (several hour) contact with the product slurry at room temperature. Initial investigations showed that the presence of both 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and HCl was sufficient in an acetonitrile solution to cause rapid corrosion of Alloy 22. More detailed mass loss studies showed initial corrosion rates exceeding 25 mm/y that then decreased over several hours to steady state rates of 3 mm/y to 5 mm/y. The corrosion was highly uniform. Electrochemical measurements demonstrated that although Alloy 22 is spontaneously passive in acetonitrile solution, the presence of HCl leads to the development of a transpassive region. DDQ is a sufficiently strong oxidizer, particularly in acidic solutions, to polarize the Alloy 22 well into the transpassive region, leading to the observed high-corrosion rates.
Comparable Decellularization of Fetal and Adult Cardiac Tissue Explants as 3D-like Platforms for In Vitro Studies (2019)

Current knowledge of extracellular matrix (ECM)-cell communication translates to large two-dimensional (2D) in vitro culture studies where ECM components are presented as a surface coating. These culture systems constitute a simplification of the complex nature of the tissue ECM that encompasses biochemical composition, structure, and mechanical properties. To better emulate the ECM-cell communication shaping the cardiac microenvironment, we developed a protocol that allows for the decellularization of the whole fetal heart and adult left ventricle tissue explants simultaneously for comparative studies. The protocol combines the use of a hypotonic buffer, a detergent of anionic surfactant properties, and DNase treatment without any requirement for specialized skills or equipment. The application of the same decellularization strategy across tissue samples from subjects of various age is an alternative approach to perform comparative studies. The present protocol allows the identification of unique structural differences across fetal and adult cardiac ECM mesh and biological cellular responses. Furthermore, the herein methodology demonstrates a broader application being successfully applied in other tissues and species with minor adjustments, such as in human intestine biopsies and mouse lung.
Influence of fiber diameter, fiber combinations and solid volume fraction on air filtration properties in nonwovens (2012)

In air filtration, nonwoven materials are known to be pertinent structures for fine filtration and moderate pressure drop. In order to develop a filter that combines good permeability and high efficiency, it is important to identify the relevant structural parameters of the nonwoven. The main criteria studied in this paper are fiber fineness, solid volume fraction and basis length (total length of fiber in unit area of nonwoven). The effect of combining different fiber diameters in order to reach the best compromise is also investigated. Our results show that the use of binary blends of different fiber diameters improves overall filtration behavior, in comparison to nonwoven filters with equivalent unimodal diameter distribution. A theoretical filtration model is used to predict filtration behavior for different structural characteristics and these predictions are compared to experimental results. However, this comparison demonstrates the limits of existing models in the case of fiber blends.
Restricted N‐terminal truncation of cardiac troponin T: a novel mechanism for functional adaptation to energetic crisis (2008)

The N-terminal variable region of cardiac troponin T (TnT) is a regulatory structure that can be selectively removed during myocardial ischaemia reperfusion by mu-calpain proteolysis. Here we investigated the pathophysiological significance of this post-translational modification that removes amino acids 1-71 of cardiac TnT. Working heart preparations were employed to study rat acute myocardial infarction and transgenic mouse hearts over-expressing the N-terminal truncated cardiac TnT (cTnT-ND). Ex vivo myocardial infarction by ligation of the left anterior descending coronary artery induced heart failure and produced cTnT-ND not only in the infarct but also in remote zones, including the right ventricular free wall, indicating a whole organ response in the absence of systemic neurohumoral mechanisms. Left ventricular pressure overload in mouse working hearts produced increased cTnT-ND in both ventricles, suggesting a role of haemodynamic stress in triggering an acute whole organ proteolytic regulation. Transgenic mouse hearts in which the endogenous intact cardiac TnT was partially replaced by cTnT-ND showed lowered contractile velocity. When afterload increased from 55 mmHg to 90 mmHg, stroke volume decreased in the wild type but not in the transgenic mouse hearts. Correspondingly, the left ventricular rapid-ejection time of the transgenic mouse hearts was significantly longer than that of wild type hearts, especially at high afterload. The restricted deletion of the N-terminal variable region of cardiac troponin T demonstrates a novel mechanism by which the thin filament regulation adapts to sustain cardiac function under stress conditions.
Outcomes of Surgical Treatment for One Hundred and Thirty-Eight Patients With Severe Sagittal Deformity at a Minimum 2-Year Follow-Up (2019)

INTRODUCTION: Operative treatment of ASD can be very challenging with high complication rates. It's well established that pts benefit from such treatment. However, the surgical outcomes for pts with severe sagittal deformity have not been reported. METHODS: Retrospective review of a prospective, multicenter adult spinal deformity (ASD) database. Inclusion criteria: operative patients age = 18, SVA = 15 cm, PI-LL = 30 degrees, and/or lumbar kyphosis = 5 degrees with a minimum 2 yr follow-up. Health-related quality of life (HRQOL) scores: Oswestry Disability Index (ODI), Short form-36 (SF36), Scoliosis Research Society (SRS22), back/leg pain numerical rating scale (NRS) and min clinically important difference (MCID)/substantial clinical benefit (SCB) for patients eligible to meet it. Radiographic values: max coronal cobb angle, coronal C7 plumb line, pelvic tilt, mismatch between pelvic incidence and lumbar lordosis, thoracic kyphosis, C7 sagittal vertical axis. Demographic, frailty, surgical, and complication data were also collected. Comparisons between 2 yr postop and baseline HRQOL/radiographic data were made. P < .05 was significant. RESULTS: About 138 patients were included from 502 operative patients (54.3% females, average age 63.3 ± 11.5 yr). Averege baseline frailty score was 4.1 ± 1.4, indicating that patients were frail. A total of 71 (51.4%) of the patients had a prior fusion. A total of 89.9% patients had posterior fusion only, with an average 11.5 ± 4.1 post levels fused. About 44.9% had 3-column osteotomy. Two standard deviations was considered for for SVA = 14.8 cm. All 2-yr postop radiographic parameters were significantly improved compared to baseline (P < .05) except coronal C7 plumb line (P > .05). All 2-yr HRQOL measures were significantly improved compared to baseline (P < .004). About 46.6% to 73.8% of patients met either MCID or SCB for all HRQOL. A total of 74.6% of patients had at least 1 complication, 11.6% had 4 or more complications, 33.3% had a minimum 1 major complication, and 42 (30.4%) had a postop revision. CONCLUSION: Patients with a severe sagittal malalignment benefit from surgical correction at 2 yr postop both radiographically and clinically despite having a high complication rate.