gebhart/patrepeval huggingface dataset:
Cubature Kalman Filter Based Training of Hybrid Differential Equation Recurrent Neural Network Physiological Dynamic Models (2021)

Modeling biological dynamical systems is challenging due to the interdependence of different system components, some of which are not fully understood. To fill existing gaps in our ability to mechanistically model physiological systems, we propose to combine neural networks with physics-based models. Specifically, we demonstrate how we can approximate missing ordinary differential equations (ODEs) coupled with known ODEs using Bayesian filtering techniques to train the model parameters and simultaneously estimate dynamic state variables. As a study case we leverage a well-understood model for blood circulation in the human retina and replace one of its core ODEs with a neural network approximation, representing the case where we have incomplete knowledge of the physiological state dynamics. Results demonstrate that state dynamics corresponding to the missing ODEs can be approximated well using a neural network trained using a recursive Bayesian filtering approach in a fashion coupled with the known state dynamic differential equations. This demonstrates that dynamics and impact of missing state variables can be captured through joint state estimation and model parameter estimation within a recursive Bayesian state estimation (RBSE) framework. Results also indicate that this RBSE approach to training the NN parameters yields better outcomes (measurement/state estimation accuracy) than training the neural network with backpropagation through time in the same setting.
High transport currents in mechanically reinforced MgB[sub 2] wires (2002)

Monofilamentary PIT-MgB2-wires with a mechanically reinforced sheath were developed. The two kinds of prepared PIT-wires had different precursors, commercial MgB2 powder or a Mg/B metallic powder mixture. Both wires were heat treated to get a dense filament. We observed a significantly different behavior of the superconducting properties. In wires with the metallic Mg/B precursors, the highest transport critical current densities of Jc=105 Acm−2 (4.2 K/0 T) were measured. The maximum of pinning was found at low fields of B=1 T and the critical current drops close to zero at fields of B=5–6 T. In wires from MgB2 powders, a significantly different transport current behavior was observed. At B=0 T, Jc=65000 Acm−2 is about 35% reduced, but towards higher fields the Jc degradation was smaller and the pinning force maximum shifts to approx. 3.5 T. A similar but much weaker behavior was observed changing the first wall in the sheath from Nb to Ta for in-situ-wires. This result shows that pinning and the superconducting performance at higher fields can be influenced and improved by the preparation route and the design of the wire composite. At temperatures close to Tc (38.4 K, midpoint), also high transport currents were found, Jc exceeds 23000 Acm−2 for T<30 K and 52000 Acm−2 at T<20 K, B=0 T. The reproducibility of the current carrying capacity of all wires was excellent, indicating dense filaments through a very successful mechanical reinforcement.
A multi-server video monitor system based on stream-media communication technology (2008)

A multi-server video monitor system based on streaming media communication technology is proposed. Large-scale, long-distance monitoring requirements have been met. The video monitor software is researched, which has the function of video restoration, proprietary protocol is used to realize video transmitting smoothly. In the part of the software programming, multi-threaded mechanism and double buffering are used to achieve real-time video displaying, communication signaling between client and servers is also designed.
A Unified Model for Shear Driven Gas Micro Flows (2002)

We analyze steady one-dimensional plane Couette flows in the entire Knudsen regime with the objective of modelling shear-driven rarefied gas flows encountered in various micro electromechanical system (MEMS) applications. In particular, we develop a unified empirical model, which includes analytical expressions for the velocity distribution and shear stress. The new model is validated by comparisons with the linearized Boltzmann solutions available in the literature, as well as hard-sphere direct simulation Monte Carlo (DSMC) results. Overall, the new model predicts the velocity distribution and shear stress with good accuracy for a wide range of Knudsen numbers (0 &amp;lt; Kn ≤ 12), and it is valid for incompressible or low subsonic compressible flows (Ma ≤ 0.3).
Poly(hydroxyalkanoate) synthase genotype and PHA production of Pseudomonas corrugata and P. mediterranea (2005)

A collection of Pseudomonas corrugata and P. mediterranea strains, two closely related species, was evaluated for the presence and variability of pha loci. Using PCR methods that specifically amplify segments of medium-chain-length poly(hydroxyalkanoate) (mcl-PHA) synthase genes, we demonstrated the presence of phaC1 and phaC2 in all P. mediterranea strains tested and in six out of 56 strains of P. corrugata screened. The remaining 50 strains of P. corrugata yielded only the phaC2 subgene fragment on detection by a combined PCR-restriction endonuclease analysis method or a semi-nested PCR-amplification approach. A Southern hybridization study on a representative strain from this group, however, indicated the presence of the phaC1 gene. Nucleic acid sequences of the subgene phaC fragments of the representative strains from the three groups showed an overall similarity ranging from 95% to 100%. The major repeat-unit monomers of the mcl-PHAs isolated from these selected strains are beta-hydroxyoctanoate (33-47 mol%) and beta-hydroxydecanoate (26-36 mol%). These results differentiate for the first time the strains of P. corrugata into two pha-distinguishable groups. This study also documents for the first time the production of mcl-PHA in P. mediterranea.
Ion Transport in a Chemically Prepared Polypyrrole/Poly(styrene-4-sulfonate) Composite (1999)

The electrochemistry of a chemically prepared polypyrrole/poly(styrene-4-sulfonate) powder has been investigated by cyclic voltammetry and impedance spectroscopy in a variety of aqueous electrolytes. The facile p-doping/undoping of thick layers of the polymer composite is shown to be due to the high ionic conductivity imparted by electrolyte solution in pores. As a consequence, the ionic conductivities of the polymer layers are strongly dependent on the concentration and conductivity of the electrolyte solution used but relatively insensitive to the doping level of the polymer. In contrast, electrochemically prepared polypyrrole/poly(styrene-4-sulfonate) films show much lower ionic conductivities with a pronounced dependence on doping level. It is concluded that layers of the chemically prepared material are approximately 10 times more porous than the electrochemically prepared films. High ionic conductivities previously obtained for polypyrrole/poly(styrene-4-sulfonate) layers bonded to Nafion membranes have been shown to be due to HNO3 generated in pores by ion exchange of residual Fe3+ with H+ in the Nafion.
Dietary Source of Stearidonic Acid Promotes Higher Muscle DHA Concentrations than Linolenic Acid in Hybrid Striped Bass (2009)

Rapid expansion of aquacultural production is placing increasing demand on fish oil supplies and intensified the search for alternative lipid sources. Many of the potential alternative sources contain low concentrations of long chain n-3 fatty acids and the conversion of dietary linolenic acid to longer chain highly unsaturated fatty acids is a relatively inefficient process in some species. A 6-week study was conducted to compare tissue fatty acid (FA) concentrations in hybrid striped bass fed either 18:3n-3 (alpha-linolenic acid; ALA) or 18:4n-3 (stearidonic acid; SDA). Hybrid striped bass were fed either a control diet containing fish oil, or diets containing ALA or SDA at three different levels (0.5, 1 and 2% of the diet). There were no significant differences in whole animal responses between fish fed ALA or SDA. Liver and muscle concentrations of ALA and SDA were responsive to dosages fed. However, only 22:6n-3 concentrations in muscle were significantly affected by dietary source of 18 carbon precursors. Muscle 22:6n-3 concentrations were significantly higher in fish fed SDA compared to fish fed ALA. Based on these data, it appears that feeding SDA can increase long chain n-3 fatty acid concentrations in fish muscle.
Porous Polymers for Biological Fixation (1988)

Porous polymers are recommended as coatings for femoral stems on the basis of their low modulus, which allows uniform distribution of stress to surrounding bone and the fabrication of more flexible stems by reducing the metallic cross section. Application of the porous polymer coating to the metallic substrate reduces metal ion release; the polymer coating does not affect the mechanical properties of the device. Porous polytetrafluoroethylene-carbon fiber composite, (PCFC), porous polyethylene, and porous polysulfone are undergoing investigation for this application. However, the low strength of the PCFC makes its use for this application questionable. Recently reported unfavorable clinical results (i.e., a high incidence of pain) have led to the discontinuation of one trial of porous polyethylene. Clinical investigation of porous polysulfone-coated titanium alloy devices are in progress. Animal studies have shown bone ingrowth into porous polyethylene and porous polysulfone implants in cortical and cancellous bone and in canine femoral stems coated with these materials. Pull-out testing of porous polysulfone implants revealed that the strength of the porous material was higher than the strength of surrounding bone. Less cortical bone loss was found around porous polysulfone-coated canine stems than was reported for fully coated porous metallic prostheses, presumably because of the lower stiffness.
Two‐Dimensional (2D) or Quasi‐2D Superstructures from DNA‐Coated Colloidal Particles (2020)

Abstract This contribution describes the synthesis of colloidal di‐patch particles functionalized with DNA on the patches and their assembly into colloidal superstructures via cooperative depletion and DNA‐mediated interactions. The assembly into flower‐like Kagome, brick‐wall like monolayer, orthogonal packed single or double layers, wrinkled monolayer, and colloidal honeycomb superstructures can be controlled by tuning the particles’ patch sizes and assembly conditions. Based on these experimental results, we generate an empirical phase diagram. The principles revealed by the phase diagram provide guidance in the design of two‐dimensional (2D) materials with desired superstructures. Our strategy might be translatable to the assembly of three‐dimensional (3D) colloidal structures.
T cell recognition of ragweed allergen Ra3: Localization of the full T cell recognition profile by synthetic overlapping peptides representing the entire protein chain (1986)

In the preceding report, we described the systematic localization of the full profile of the continuous antigenic sites on ragweed allergen, Ra3, with antibodies from three different host species using a comprehensive strategy, previously introduced by this laboratory. The strategy consists of studying the immunochemical activity of a series of consecutive synthetic overlapping peptides, of uniform size and overlaps, which encompass the entire protein chain. This study reports the localization of the continuous regions on Ra3 that are recognized by T cells from mice immunized with Ra3. The 10 overlapping peptides encompassing the entire Ra3 molecule were examined in vitro for their ability to stimulate lymph node cells from Ra3-primed BALB/c (H-2d), C3H/He (H-2k) SWR (H-2q) and SJL (H-2s) mice. Several regions of the molecule (T sites) were found to stimulate Ra3-primed lymph node cells. This strategy has enabled the localization of the full submolecular profile of T cell recognition of the Ra3 molecule by these mouse strains. Three of the regions recognized by T cells coincided with regions recognized by antibodies (i.e. B cells). It is noteworthy that in addition to sites recognized by both T and B cells the protein has at least one site which is recognized exclusively by T cells and to which no detectable antibody response is directed.
Table S3 from Suppression of STING Associated with LKB1 Loss in KRAS-Driven Lung Cancer (2023)

&lt;p&gt;Table S3 shows list of KRAS WT; LKB1 WT and KRAS WT; LKB1 Mut lung adenocarcinoma cell lines related with supplementary figure S1.&lt;/p&gt;
Mechanisms for store-wait-free multiprocessors (2007)

Store misses cause significant delays in shared-memory multiprocessors because of limited store buffering and ordering constraints required for proper synchronization. Today, programmers must choose from a spectrum of memory consistency models that reduce store stalls at the cost of increased programming complexity. Prior research suggests that the performance gap among consistency models can be closed through speculation--enforcing order only when dynamically necessary. Unfortunately, past designs either provide insufficient buffering, replace all stores with read-modify-write operations, and/or recover from ordering violations via impractical fine-grained rollback mechanisms. We propose two mechanisms that, together, enable store-wait-free implementations of any memory consistency model. To eliminate buffer-capacity-related stalls, we propose the scalable store buffer, which places private/speculative values directly into the L1 cache, thereby eliminating the non-scalable associative search of conventional store buffers. To eliminate ordering-related stalls, we propose atomic sequence ordering, which enforces ordering constraints over coarse-grain access sequences while relaxing order among individual accesses. Using cycle-accurate full-system simulation of scientific and commercial applications, we demonstrate that these mechanisms allow the simplified programming of strict ordering while outperforming conventional implementations on average by 32% (sequential consistency), 22% (SPARC total store order) and 9% (SPARC relaxed memory order).
Reviews and Notes: Gastroenterology: Infections of the Gastrointestinal Tract (1996)

Literature of Medicine1 July 1996Reviews and Notes: Gastroenterology: Infections of the Gastrointestinal TractAndrew G. Plaut, MDAndrew G. Plaut, MDTufts University School of Medicine, New England Medical Center, Boston, MA 02111Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-1-199607010-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail MJ Blaser, PD Smith, JI Ravdin, HB Greenberg, and RL Guerrants; eds. 1610 pages. New York: Raven; 1995. $245.00. ISBN 0781702267. Order phone 800-772-2295.Approximately 150 authors involved both in the care of patients and research on gut infections have packed this single-volume text with information. The 97 chapters begin with a brief history of the field and then cover infections caused by viruses, bacteria, fungi, and metazoan and protozoan parasites; infections caused by unclassifiable microorganisms; and well-classified organisms whose role in infections is uncertain. There are chapters on epidemiology, the clinical laboratory in diagnosis, prophylaxis for surgery, radiology, endoscopy ... Author, Article, and Disclosure InformationAffiliations: Tufts University School of Medicine, New England Medical Center, Boston, MA 02111 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1996Volume 125, Issue 1Page: 79KeywordsAntibioticsGastrointestinal infectionsGastrointestinal tractProtozoan infectionsProtozoansSchistosomiasisSurgeryToxinsTropical diseasesVaccines ePublished: 15 August 2000 Issue Published: 1 July 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Rigid-Body Motion Tolerance for Industrial Helical CT Measurements of Logs (2016)

The major cost in sawmills is the log raw material. It is therefore important to maximize the value of the product yielded from each log. Computed Tomography (CT) has been explored as a sensing solution for determining log defects and making data-driven choices in product breakdown. However, the harsh conditions of the sawmill environment lead to limitations in data acquisition and log manipulation. This paper presents an iterative-solver CT reconstruction scheme that includes rigid-body motion compensation, greatly increasing reconstruction robustness for misalignments in the radiographic data. The motion compensation is carried out by using the known nominal distribution of density in softwood logs to approximate the geometric center of the log and its radius from the radiographs. This is then applied to an iterative reconstruction methodology based on a log-specific voxel geometry previously developed. The method is validated for synthetic phantoms, a physical phantom, as well as real log samples. Results indicate that the rigid body compensation effectively ameliorates motion blur for movement within in the detector field of view.
Convex Lifting: Theory and Control Applications (2017)

This paper presents the concept of convex lifting, which will be proven to enable significant implementation benefits for the class of piecewise affine controllers. Accordingly, two different algorithms to construct a convex lifting for a given polyhedral/polytopic partition will be presented. These two algorithms rely on either the vertex or the halfspace representation of the related polyhedra. Also, we introduce an algorithm to refine a polyhedral partition, which does not admit a convex lifting, into a convexly liftable one. Furthermore, two different schemes will be put forward to considerably reduce both the memory footprint and the online evaluation effort, which play a key role in implementation of piecewise affine controllers. Finally, these results will be illustrated via numerical examples and a complexity analysis.
Rapid inactivation of Toxoplasma gondii bradyzoites during formulation of dry cured ready-to-eat pork sausage (2018)

Curing processes for pork meat in the U.S. currently require individual validation of methods to demonstrate inactivation of <i>Trichinella spiralis</i>, a nematode parasite historically associated with pork. However, for protozoan parasites, no such strictures exist. It has been assumed, with little evidence, that curing processes required to inactivate <i>Trichinella</i> also inactivate <i>Toxoplasma gondii</i>. Currently no model of meat chemistry exists that can be correlated with inactivation of <i>T. gondii</i>. Given the possibility of the presence of <i>T. gondii</i> in pork meat, and the frequent use of pork for ready-to-eat (RTE) products not intended to be cooked, curing methods which inactivate <i>T. gondii</i> early in the curing process would be of great value to producers. In this study, we tested the effect of five variables - salt/brine concentration, water activity (a<sub>w</sub>), pH, temperature, and time on inactivation of <i>T. gondii</i> bradyzoites in tissue cysts using low and high endpoints for common curing treatments during preparation of dry cured pork sausage. Survival of <i>T. gondii</i> bradyzoites at each stage of preparation was assessed using a mouse bioassay. Results indicated that encysted <i>T. gondii</i> bradyzoites do not survive the early stages of the dry curing process within the endpoint parameters tested here, even at levels of NaCl that are lower than typically used for dry curing (1.3%). Exposure of <i>T. gondii</i> encysted bradyzoites to curing components in the formulated batter resulted in rapid inactivation of bradyzoites. These data suggest that the use of dry curing components may be effective for controlling <i>T. gondii</i> potentially transmitted through RTE meats, rendering them safe from risk with respect to <i>T. gondii</i> transmission to human consumers.
Review of the first 1502 cases of ECG‐ST waveform analysis during labour in a teaching hospital (2007)

Our experience suggests the need for more intense training on interpretation of CTG and strict adherence to guidelines.
A Hybrid Video Coder Based on Extended Macroblock Sizes, Improved Interpolation, and Flexible Motion Representation (2010)

This paper describes a video coding technology proposal submitted by Qualcomm in response to a joint call for proposals (CfP) issued by ITU-T SG16 Q.6 (VCEG) and ISO/IEC JTC1/SC29/WG11 (MPEG) in January 2010. The proposed video codec follows a hybrid coding approach based on temporal prediction, followed by transform, quantization, and entropy coding of the residual. Some of its key features are extended block sizes (up to 64 <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\,\times\,$</tex></formula> 64), single pass switched interpolation filters with offsets, mode-dependent directional transforms for intra-coding, luma and chroma high precision filtering, geometric motion partitions, adaptive motion vector resolution and efficient 16-point transforms. It also incorporates internal bit-depth increase and modified quadtree-based adaptive loop filtering. Simulation results are presented to demonstrate the high compression efficiency achieved by the proposed video codec at the expense of moderate increase in encoding and decoding complexity compared to the advanced video coding standard (AVC/H.264). For the random access and low delay configurations, it achieved average bit rate reductions of 30.9% and 33.0% for equivalent peak signal-to-noise ratio, respectively, compared to the corresponding AVC anchors. The proposed codec scored highly in both subjective evaluations and objective metrics and was among the best-performing CfP proposals.
CARBON MONOXIDE PREVENTS REJECTION OF CARDIAC ALLOGRAFTS VIA ACTIVATION OF HIF1A; (2008)

Thomas, M N.; Macdonald, T; Csizmadia, E; Bösch, F; Bach, F H.; Otterbein, L E.; Chin, B Y. Author Information
A Randomized Trial of Adjuvant BCG Immunotherapy in Head and Neck Cancer (1983)

Fifty-two patients with locally advanced squamous cell cancer were entered into a randomized trial of BCG vaccine following definitive local therapy. Patients were stratified and randomized to receive BCG vaccine (25 patients) or no adjuvant immunotherapy (27 patients). The BCG vaccine therapy began two weeks following definitive therapy with 2 to 4 X 10(6) Tice strain BCG organisms given intradermally (ID) in alternating sides of the neck every two weeks six times, then every four weeks nine times. In addition, all patients received methotrexate prior to definitive therapy. Median duration of follow-up at the time of analysis was 41 months. Groups were balanced by sex, disease site and stage, histologic grade, and prior therapy. Thirteen (52%) of the BCG vaccine-treated group remain disease free v seven (26%) of the controls. Similarly, 17 (68%) of the BCG vaccine-treated group survived v 11 (41%) of the controls. We conclude regional ID BCG vaccine increases disease-free and actuarial survival in this study population and adjuvant immunotherapy should be further explored in ear, nose, and throat cancer.