gebhart/patrepeval huggingface dataset:
Recovery of herpesviruses from cerebrospinal fluid of immunodeficient homosexual men (1985)

Over a one-year period the cerebrospinal fluid (CSF) obtained from a series of homosexual men immunocompromised with either Hodgkin's disease or acquired immune deficiency syndrome (AIDS) was cultured to assess the frequency with which infectious viruses could be recovered. Of 58 patients examined, 4 (6.9%) had CSF cultures that showed a cytopathology consistent with a virus infection. All isolates proved to be herpesviruses. Cytomegalovirus (CMV) and varicella-zoster virus were isolated from CSF obtained from 2 patients with neurological features consistent with a subacute encephalitis common among AIDS patients. CMV was also recovered from the CSF of an AIDS patient who developed an ascending myelitis of herpesvirus origin. Finally, a CSF sample obtained from an immunodeficient homosexual man who showed no detectable neurological abnormalities consistently yielded herpes simplex virus type 1 in culture. These results suggest that seeding of the CSF with infectious virus is an uncommon event in this patient population. However, our experience should not dissuade attempts to culture viruses from CSF in similar cases. Successful isolations may prove beneficial in the diagnosis of an accompanying neurological illness and facilitate treatment with antiviral therapy when indicated.
Influence of Relative Humidity on the Thermomechanical Behavior of PA6.6 (2014)

An experimental protocol was developed to achieve complete energy balances associated with low cycle fatigue (LCF) of a polyamide 6.6 matrix (PA6.6). The protocol involves quantitative infrared techniques (IRT), and digital speckle image correlation (DIC). IRT data were used with a local heat diffusion equation to estimate strain-induced heat sources, namely dissipation and coupling sources, while DIC enabled strain and stress assessments. Both techniques were then successfully combined to quantify deformation, dissipated and stored energies and then to estimate the Taylor-Quinney ratio that is widely used in plasticity. In this paper, the effects of loading frequency and relative humidity were investigated. It was shown that an increase of relative humidity resulted in a decrease in the mean stored energy rate per cycle, while the stored energy ratio was much smaller at low than at high loading frequency. In addition, it was found that this ratio could be negative at the last fatigue stage, just before macroscopic crack inception. These energy properties will act safeguards for the future development of a thermomechanical model of PA6.6 matrix behavior.
Application of ferrite composites and silica magnetic particles to the isolation of genomic DNA (2004)

For DNA isolation silica or cobalt ferrite (unmodified or
covered with different reagents) particles were used.The size
of particles ranged from 100 to 300 nm. Genomic DNAs from
Lactococcus and Lactobacillus cells were isolated under high
poly(ethylene glycol) (PEG) and sodium chloride concentrations.
The quality of isolated DNA was tested with PCR amplification.
Quasi-3D Numerical Model and Experimental Study on Current field in the Opening of Artificial Reef (2014)

This study focuses on the hydrodynamics in the opening of artificial reefs and the applicability of a quasi-three dimensional nearshore current model with the wave-current interaction. First, the characteristics of the waves and steady currents in the opening area were investigated using the wave flume under irregular wave conditions. Secondly, the numerical model was calibrated and verified by comparing with the experiment results. Finally, the numerical model was applied to the results of a field investigation conducted at Uradome Beach in Tottori, Japan. The computed wave and steady current fields in the opening of two artificial reefs were compared with the measured data. From the computed results, we found that the numerical model gives reliable results to the prediction of the hydrodynamics around the artificial reefs.
ChemInform Abstract: Advances in Coal Analyses and Simulations 1989‐2012 (2013)

Abstract Review: 85 refs.
Coronary Stent Strut Fractures: Classification, Prevalence and Clinical Associations (2021)

The prevalence of OCT-diagnosed SF was unexpectedly high in the setting of elective controls and it increased by about three-fold in the setting of device failure. Fractures were associated with increased lesion complexity and device asymmetry/eccentricity and were more frequent in the setting of device failure such as restenosis and thrombosis.
Derivatives of 2-hydroxy-4-mercapto-6-methylpyrimidine-5-carboxylic acid. II. Pirazolo-[3,4-d]-pyrimidine and hydrazinopyrimidine. (1976)

Heating of 2-hydroxy-4-mercapto-6-methylpyrimidine-5-carboxylic acid 1 with hydrazine or its derivatives in ethanolic solution gave 4-hydrazino derivatives 10--12. However, at 150--160 degrees in the absence of a solvent after decarboxylation the 4-hydrazino derivatives 13 and 14 were formed. Under similar conditions form 2 (the ethyl ester of 1), 4-methylpyrazole-[3,4-d]-5(H)-pyrimidine-3,6-dione and the corresponding 1--substituted derivatives 3,7,8 of this ring system were obtained. These compounds were easily chlorinated (POCl3/PCl5) in 6 and 3 and 6 position. Compounds 3 and 7 have strong cytostatic activity in vitro and in vivo, compound 13 acts as virostatic and antiinflammatory.
Role of Phospholipid Oxidation Products in Atherosclerosis (2012)

There is increasing clinical evidence that phospholipid oxidation products (Ox-PL) play a role in atherosclerosis. This review focuses on the mechanisms by which Ox-PL interact with endothelial cells, monocyte/macrophages, platelets, smooth muscle cells, and HDL to promote atherogenesis. In the past few years major progress has been made in identifying these mechanisms. It has been recognized that Ox-PL promote phenotypic changes in these cell types that have long-term consequences for the vessel wall. Individual Ox-PL responsible for specific cellular effects have been identified. A model of the configuration of bioactive truncated Ox-PL within membranes has been developed that demonstrates that the oxidized fatty acid moiety protrudes into the aqueous phase, rendering it accessible for receptor recognition. Receptors and signaling pathways for individual Ox-PL species are now determined and receptor independent signaling pathways identified. The effects of Ox-PL are mediated both by gene regulation and transcription independent processes. It has now become apparent that Ox-PL affects multiple genes and pathways, some of which are proatherogenic and some are protective. However, at concentrations that are likely present in the vessel wall in atherosclerotic lesions, the effects promote atherogenesis. There have also been new insights on enzymes that metabolize Ox-PL and the significance of these enzymes for atherosclerosis. With the knowledge we now have of the regulation and effects of Ox-PL in different vascular cell types, it should be possible to design experiments to test the role of specific Ox-PL on the development of atherosclerosis.
Bioelectrochemical Properties of Enzyme-Containing Multilayer Polyelectrolyte Microcapsules Modified with Multiwalled Carbon Nanotubes (2019)

This work investigated changes in the biochemical parameters of multilayer membrane structures, emerging at their modification with multiwalled carbon nanotubes (MWCNTs). The structures were represented by polyelectrolyte microcapsules (PMCs) containing glucose oxidase (GOx). PMCs were made using sodium polystyrene sulfonate (polyanion) and poly(allylamine hydrochloride) (polycation). Three compositions were considered: with MWCNTs incorporated between polyelectrolyte layers; with MWCNTs inserted into the hollow of the microcapsule; and with MWCNTs incorporated simultaneously into the hollow and between polyelectrolyte layers. The impedance spectra showed modifications using MWCNTs to cause a significant decrease in the PMC active resistance from 2560 to 25 kOhm. The cyclic current-voltage curves featured a current rise at modifications of multilayer MWCNT structures. A PMC-based composition was the basis of a receptor element of an amperometric biosensor. The sensitivity of glucose detection by the biosensor was 0.30 and 0.05 μA/mM for PMCs/MWCNTs/GOx and PMCs/GOx compositions, respectively. The biosensor was insensitive to the presence of ethanol or citric acid in the sample. Polyelectrolyte microcapsules based on a multilayer membrane incorporating the enzyme and MWCNTs can be efficient in developing biosensors and microbial fuel cells.
Large energy product enhancement in perpendicularly coupled MnBi/CoFe magnetic bilayers (2016)

We demonstrate substantial enhancement in the energy product of MnBi-based magnets by forming robust ferromagnetic exchange coupling between a MnBi layer and a thin CoFe layer in a unique perpendicular coupling configuration, which provides increased resistance to magnetization reversal. The measured nominal energy product of $172\phantom{\rule{0.16em}{0ex}}\mathrm{kJ}/{\mathrm{m}}^{3}$ at room temperature is the largest value experimentally attained for permanent magnets free of expensive raw materials. Our finding shows that exchange-coupled MnBi/CoFe magnets are a viable option for pursuing rare-earth-free magnets with energy products approaching those containing rare-earth elements.
Online Algorithms (1995)

ALL the algorithms we have studied so far receive their entire inputs at one time. We turn our attention to online algorithms, which receive and process the input in partial amounts. In a typical setting, an online algorithm receives a sequence of requests for service. It must service each request before it receives the next one. In servicing each request, the algorithm has a choice of several alternatives, each with an associated cost. The alternative chosen at a step may influence the costs of alternatives on future requests. Examples of such situations arise in data-structuring, resource-allocation in operating systems, finance, and distributed computing.
Gestural auditory and visual interactive platform (2011)

This paper introduces GAVIP, an interactive and immersive platform allowing for audio-visual virtual objects to be controlled in real-time by physical gestures and with a high degree of intermodal coherency. The focus is particularly put on two scenarios exploring the interaction between a user and the audio, visual, and spatial synthesis of a virtual world. This platform can be seen as an extended virtual musical instrument that allows an interaction with three modalities: the audio, visual and spatial modality. Intermodal coherency is thus of particular importance in this context. Possibilities and limitations offered by the two developed scenarios are discussed and future work presented.
End-to-End Video Classification with Knowledge Graphs (2017)

Video understanding has attracted much research attention especially since the recent availability of large-scale video benchmarks. In this paper, we address the problem of multi-label video classification. We first observe that there exists a significant knowledge gap between how machines and humans learn. That is, while current machine learning approaches including deep neural networks largely focus on the representations of the given data, humans often look beyond the data at hand and leverage external knowledge to make better decisions. Towards narrowing the gap, we propose to incorporate external knowledge graphs into video classification. In particular, we unify traditional "knowledgeless" machine learning models and knowledge graphs in a novel end-to-end framework. The framework is flexible to work with most existing video classification algorithms including state-of-the-art deep models. Finally, we conduct extensive experiments on the largest public video dataset YouTube-8M. The results are promising across the board, improving mean average precision by up to 2.9%.
Patient Selection for Diagnostic Coronary Angiography and Hospital-Level Percutaneous Coronary Intervention Appropriateness (2014)

In a national sample of hospitals, performance of coronary angiography in asymptomatic patients was associated with higher rates of inappropriate PCI and lower rates of appropriate PCI. Improving preprocedural risk stratification and thresholds for coronary angiography may be one strategy to improve the appropriateness of PCI.
GENETICS OF THE PAPAYA (1953)

Journal Article GENETICS OF THE PAPAYA Get access W. B. STOREY W. B. STOREY *Horticulturist, University of Hawaii, Agricultural Experiment Station Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Heredity, Volume 44, Issue 2, March 1953, Pages 70–78, https://doi.org/10.1093/oxfordjournals.jhered.a106358 Published: 01 March 1953 Article history Received: 02 September 1952 Published: 01 March 1953
Phy-Mer: a novel alignment-free and reference-independent mitochondrial haplogroup classifier (2014)

Supplementary data are available at Bioinformatics online.
Purification of poly-ubiquitinated proteins by S5a-affinity chromatography (2001)

Poly-ubiquitination, the post-translational covalent conjugation of isopeptide-linked chains of ubiquitin to other target proteins, is the central signal for proteolytic degradation by the 26S proteasome complex. The S5a subunit of the 26S proteasome binds poly-ubiquitin chains containing four or more ubiquitins. We have used an immobilised glutathione-S-transferase (GST)-S5a fusion protein to purify poly-ubiquitinated proteins from mammalian tissues, with the intention of expanding the repertoire of known substrates of the ubiquitin pathway. A complex mixture of poly-ubiquitinated proteins was successfully purified from normal pig brain extract following induction of in vitro ubiquitination. Western blots of two-dimensional gels of this mixture showed at least two diagonal series of ubiquitin-positive spots. Individual spots in each series were separated by approximately 9 kDa suggesting that they represent poly-ubiquitinated proteins with increasing numbers of ubiquitins in the chains. S5a-binding proteins purified from ubiquitination-induced human placental extracts, resolved by sodium dodecyl sulfate polyacrylamide gel electrophoresis and visualised by Coomassie staining, contained a single major species with an apparent denatured molecular mass of approximately 60 kDa. Edman degradation identified this protein as hHR23B, a human homologue of the Saccharomyces cerevisiae DNA repair protein Rad23p. In this case hHR23B is not ubiquitinated but instead contains an intrinsic ubiquitin-like domain at its N-terminus, through which it interacts with S5a (Hiyama, H., et al., J Biol. Chem. 1999, 274, 28,019-28,025).
Multifunctional Triblock Nanocarrier (PAMAM-PEG-PLL) for the Efficient Intracellular siRNA Delivery and Gene Silencing (2011)

A novel triblock poly(amido amine)-poly(ethylene glycol)-poly-l-lysine (PAMAM-PEG-PLL) nanocarrier was designed, synthesized, and evaluated for the delivery of siRNA. The design of the nanocarrier is unique and provides a solution to most of the common problems associated with the delivery and therapeutic applications of siRNA. Every component in the triblock nanocarrier plays a significant role and performs multiple functions: (1) tertiary amine groups in the PAMAM dendrimer work as a proton sponge and play a vital role in the endosomal escape and cytoplasmic delivery of siRNA; (2) PEG, a linker connecting PLL and PAMAM dendrimers renders nuclease stability and protects siRNA in human plasma; (3) PLL provides primary amines to form polyplexes with siRNA through electrostatic interaction and also acts as penetration enhancer; and (4) conjugation to PEG and PAMAM reduced toxicity of PLL and the entire triblock nanocarrier PAMAM-PEG-PLL. The data obtained show that the polyplexes resulted from the conjugation of siRNA, and the proposed nanocarriers were effectively taken up by cancer cells and induced the knock down of the target BCL2 gene. In addition, triblock nanocarrier/siRNA polyplexes showed excellent stability in human plasma.
Quercetin‐Based Modified Porous Silicon Nanoparticles for Enhanced Inhibition of Doxorubicin‐Resistant Cancer Cells (2016)

One of the most challenging obstacles in nanoparticle's surface modification is to achieve the concept that one ligand can accomplish multiple purposes. Upon such consideration, 3-aminopropoxy-linked quercetin (AmQu), a derivative of a natural flavonoid inspired by the structure of dopamine, is designed and subsequently used to modify the surface of thermally hydrocarbonized porous silicon (PSi) nanoparticles. This nanosystem inherits several advanced properties in a single carrier, including promoted anticancer efficiency, multiple drug resistance (MDR) reversing, stimuli-responsive drug release, drug release monitoring, and enhanced particle-cell interactions. The anticancer drug doxorubicin (DOX) is efficiently loaded into this nanosystem and released in a pH-dependent manner. AmQu also effectively quenches the fluorescence of the loaded DOX, thereby allowing the use of the nanosystem for monitoring the intracellular drug release. Furthermore, a synergistic effect with the presence of AmQu is observed in both normal MCF-7 and DOX-resistant MCF-7 breast cancer cells. Due to the similar structure as dopamine, AmQu may facilitate both the interaction and internalization of PSi into the cells. Overall, this PSi-based platform exhibits remarkable superiority in both multifunctionality and anticancer efficiency, making this nanovector a promising system for anti-MDR cancer treatment.
Quantitative simulation and qualitative analysis of theory X, Y and Z (2013)

Quantitative simulation has a significant influence on the research of management theories. Through a valid simulation, the motivation effect of the management theories can be seen directly from the simulation results. Then which theory is needed for a specific corporation and what we can do to develop the theory can be revealed. This research realizes the quantitative simulation of McGregor's XY Theory and Theory Z by agent model, quantified appraising performance and qualitative analysis. Based on the quantitative simulation result, a new qualitative simulation is realized which can help us to analyze the effect of the three theories. At last, we make a conclusion that Theory X and Y are only suited to motivate workers with a special attitude or character, while Theory Z has more power on different attitude workers. Therefore, Theory Z is more advanced than Theory XY.
Youth Football Helmet STAR Methodology (2019)

This document details the protocol used by the Virginia Tech Helmet Ratings to rate youth football helmets based on concussion risk.
Studies of IL28B genotype and response to peginterferon in chronic hepatitis B should be stratified by HBV genotype (2012)

In this issue of Hepatology, Lampertico et al.1 present a study of mostly hepatitis B virus (HBV) genotype D hepatitis B e antigen (HBeAg)-negative chronic hepatitis B (CHB) patients treated with peginterferon (PEG-)IFN and show that hepatitis B s antigen (HBsAg) loss was significantly associated with IL28B genotype. Our group recently published a study on the association of IL28B genotype with response to PEG-IFN in HBeAg-positive CHB patients. Favorable IL28B genotypes, CC for rs12979860 and AA for rs12980275, were associated with higher rates of HBeAg seroconversion and HBsAg loss.2 Taken together, these findings provide mounting evidence for the importance of the IL28B genotype for prediction of response to PEG-IFN in CHB, although these findings require further confirmation. There is, however, an important pitfall that should be taken into consideration. In our study, IL28B genotype distribution varied across ethnicity: 90% of Asian patients were genotyped CC, compared to 50% of non-Asians.2 Response to PEG-IFN in CHB also depends on the HBV genotype: patients with HBV genotype A achieve higher rates of response than those with HBV genotypes B, C, or D.3 Importantly, HBV genotypes A and D predominate in Caucasians, and nearly all south east Asian patients are infected with HBV genotypes B or C. Because IL28B genotype is associated with ethnicity, it is also associated with HBV genotype. In our study of HBeAg-positive patients, the favorable IL28B genotype was present in 42% of HBV genotype A patients, in 88%-90% of patients with HBV genotypes B or C, and in 52% of HBV genotype D patients.2 If differences in HBV genotype distribution are ignored, analyses of the association between IL28B genotype and HBsAg loss in a cohort of patients with mixed ethnicities could result in an overrepresentation of Asian patients (with “poor response” HBV genotypes B or C) in the favorable CC group, and an overrepresentation of Caucasians and black Africans (with “good response” HBV genotype A) in the unfavorable CT/TT groups. This could result in a biased estimate of association, or failure to detect one. This issue is particularly relevant for studies conducted in countries with mixed ethnicities, such as those in Western Europe and the United States, where the HBV-infected population comprises Caucasians, Asians, and black Africans. In conclusion, the study by Lampertico et al. provides fascinating new data and urges further studies of IL28B genotype and response to PEG-IFN in CHB. However, the association of IL28B genotype distribution with that of HBV genotype may introduce an important pitfall. Therefore, we strongly recommend that future studies of IL28B in CHB be stratified by, or adjusted for, HBV genotype. Milan J. Sonneveld MSc*, Willem P. Brouwer MD*, Harry L.A. Janssen MD, PhD*, * Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.