gebhart/patrepeval huggingface dataset:
Abstract PO-142: Analysis of the genomic landscapes of Barbadian and Nigerian women with triple negative breast cancer (2022)

Abstract Women of African ancestry (WAA) are disproportionately affected by the aggressive triple negative breast cancer (TNBC) subtype that is often associated with high recurrence rates and metastasis. Although there is a high prevalence of TNBC across West Africa and in women of the African diaspora, there has been no comprehensive genomics study to investigate the mutational profile of ancestrally related women across the Caribbean and West Africa. To shed more light on this phenomenon, whole exome sequencing (WES) was performed on 31 formalin-fixed paraffin-embedded TNBC tissues from ancestrally related Barbadian and Nigerian women. We compared these genomics profiles with data from The Cancer Genome Atlas (TCGA) for African American (TCGA-AA), European American (TCGA-EA) women with TNBC. With an average coverage of 382x for tumour samples (n= 31) and 4335x for pooled germline (n=22) non-tumor samples, the most mutated genes in our cohorts include NBPF12, PLIN4, TP53 and BRCA1. For TCGA TNBC cases, these genes had a lower mutation rate, except for TP53 (32% in our cohort; 63% in TCGA-AA; 67% in TCGA-EA). For all altered genes, there were no differences in frequency of mutations between WAA TNBC groups including the TCGA-AA cohort. Additionally, we observed a high frequency of copy number variant alterations in PIK3CA, TP53, FGFR2 and HIF1AN genes. This study provides in-depth insights into the underlying genomic alterations in WAA-TNBC samples and shines light on the importance of inclusion of non-European populations in cancer genomics and biomarker studies. Citation Format: Shawn M. Hercules, Xiyu Liu, Blessing I. Bassey-Archibong, Desiree H.A. Skeete, Suzanne Smith Connell, Adetola Daramola, Adekunbiola A.F. Banjo, Godwin Ebughe, Thomas Agan, Ima-Obong Ekanem, Joe E. Udosen, Christopher Obiorah, Aaron C. Ojule, Michael A. Misauno, Ayuba M. Dauda, Ejike C. Egbujo, Jevon C. Hercules, Amna Ansari, Ian Brain, Christine MacColl, Yili Xu, Yuxin Jin, Sharon Chang, John D. Carpten, André Bédard, Gregory R. Pond, Kim R.M. Blenman, Zarko Manojlovic, Juliet M. Daniel. Analysis of the genomic landscapes of Barbadian and Nigerian women with triple negative breast cancer [abstract]. In: Proceedings of the AACR Virtual Conference: 14th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2021 Oct 6-8. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr PO-142.
Highlights from the Transcatheter Cardiovascular Therapeutics 2021 meeting (2022)

The authors declare that they have no conflicts of interest with the contents of this article.
Experimental study on the characteristic of the NS-GT cut quartz crystal resonator oscillating in the sub-resonant frequency (1999)

We previously reported that the dynamic photo-elastic method was a very effective measuring technique for the stress distribution of vibrating quartz crystal resonators. The existence of a twisted asymmetrical vibration mode has been verified experimentally when the NS-GT cut quartz crystal resonator was vibrating in the main resonant frequency (MRF). A MRF and a sub-resonant frequency (SRF) of the NS-GT cut quartz resonator were defined as follows. If a mechanical standing wave was in the x' or y' direction of the resonator, the former was MRF vibration and the latter was SRF vibration, respectively. In this paper, stress distributions of two samples of the NS-GT cut quartz crystal resonator, one of which had a thickness of 80 mum and the other 150 mum, were measured by the dynamic photo-elastic method when the resonators were vibrating in each SRF. Thereafter, vibration modes of those resonators were estimated by the experimental data of stress distributions. We find that the vibration mode of the 80-mum resonator had a simple mechanical standing wave on the y' direction and the vibration mode of the 150-mum resonator was combined with a shearing mode in the SRF vibration. From the experiment, we decided that vibration modes of the NS-GT cut quartz crystal resonator were composed of the longitudinal stress T(3)' belonging to the z' direction of the plate and of the shearing stress T(5)' when the plate thickness was thickened and the resonator was oscillating in the SRF.
Origins of Rydberg-Atom Electrometer Transient Response and Its Impact on Radio-Frequency Pulse Sensing (2022)

Rydberg atoms show significant promise as the basis for highly sensitive detectors of continuous radio-frequency (rf) electric fields (E fields). Here, we study their time-dependent response to pulse-modulated rf E fields at 19.4 GHz using a cesium vapor cell at room temperature. We use density-matrix simulations to explain the timescales that shape the transient atomic response under different laser conditions, finding them to be limited by dephasing mechanisms, including transit-time broadening, Rydberg-Rydberg collisions, and ionization. Using a matched filter, we demonstrate the detection of individual pulses with durations from 10 \textmu{}s down to 50 ns and amplitudes from 15 000 \textmu{}V ${\mathrm{cm}}^{\ensuremath{-}1}$ down to about 170 \textmu{}V ${\mathrm{cm}}^{\ensuremath{-}1}$, corresponding to a sensitivity of about 240 nV ${\mathrm{cm}}^{\ensuremath{-}1}$ ${\mathrm{Hz}}^{\ensuremath{-}1/2}$. Finally, we highlight the potential of a Rydberg vapor cell as a receiver by detecting pulse trains from a rotating emitter on a simulated passing aircraft.
New mutations in C1GALT1C1 in individuals with Tn positive phenotype (2008)

Tn polyagglutination results from inactivating mutations in C1GALT1C1, an X-borne gene encoding a core 1 beta3-galactosyltransferase-specific molecular chaperone (cosmc) required for the functioning of T-synthase (beta 1,3-galactosyltransferase), a glycosyltransferase essential for the correct biosynthesis of O-glycans. This study found novel inactivating mutations (Glu152Lys, Ser193Pro and Met1Ile) in the coding sequence of C1GALT1C1 in three Tn positive individuals and a complete lack of C1GALT1C1 cDNA expression was observed in an additional Tn positive individual. In addition, expression of ST6GALNAC1, which encodes (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1, 3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and gives rise to sialyl-Tn antigen, was present at comparable levels in normal and Tn-positive human erythroblasts. Expression studies of wild-type and Tn positive C1GALT1C1 cDNA in the Jurkat cell line confirmed that the amino acid substitutions observed in Tn are inactivating. Analysis of the transcriptome of cultured normal and Tn positive erythroblasts revealed numerous differences in gene expression. Reduced transcript levels for fatty acid binding protein 5 (FABP5) and plexin D1 (PLXND1), and increased levels for aquaporin 3 (AQP3) were confirmed by quantitative real-time polymerase chain reaction. These data show that alteration of O-glycan structures resulting from T-synthase deficiency is accompanied by altered expression of a wide variety of genes in erythroid cells.
Mechanisms of injection enhancement in organic light-emitting diodes through an Al/LiF electrode (2001)

The mechanisms of enhanced electron injection into the electron transport layer of Alq3 [tris(8-hydroxyquinoline)-aluminum] via LiF interlayers are studied by means of I–V characteristics, secondary ion mass spectroscopy (SIMS), and Kelvin probe measurements. Devices for single carrier injection were prepared using aluminum electrodes, Alq3 electron transport layers, and thin intermediate layers of LiF. It was found that devices deposited in the order Alq3-LiF-aluminum have a much higher electron injection capability than structures deposited in the order aluminum-LiF-Alq3. SIMS depth profile analysis reveals that the evaporation of Al on LiF leads to a spatial separation of Li and F probably induced by a chemical reaction of Al with LiF. Simple thermodynamic calculations support the energetic feasibility of such a reaction. Titanium cathodes in the same layer sequence also exhibit electron injection enhancement, probably due to their similar chemical reactivity. However, electron injection from Ag electrodes is not significantly improved by the introduction of a LiF interlayer.
45nm node logic device OPE matching between exposure tools through laser bandwidth tuning (2008)

For 45 nm Node logic devices, we have investigated the impact of laser bandwidth fluctuation on Optical Proximity Effect (OPE) by evaluating variation in through-pitch critical dimension (CD) performance. In addition, from these results we have calculated the Iso-Dense Bias (IDB), and determined the sensitivity to laser bandwidth fluctuation. These IDB results also enable us to present the laser bandwidth stability that is required to maintain a constant OPE. And finally, we introduce results from an investigation into OPE-matching between different generations of exposure tools, whereby in addition to laser bandwidth control, tilt-scan methodology was employed.
Demonstration of elastic recoil detection as a technique for quantifying 6Li burnup in tritium breeder materials (2019)

Lithium-6 enriched lithium aluminate, LiAlO2, is utilized as the tritium breeding material in Tritium Producing Burnable Absorber Rods (TPBARs). TPBARs are now the primary approach for maintaining the United States’ tritium supply. When positioned inside a fission reactor, 6Li absorbs neutrons and transmutes into 3H+4He. Hydrogen and helium accumulation will eventually result in significant material degradation and mechanical failure. Individual light isotope concentrations would provide beneficial information for predicting accumulation levels required for material degradation to occur, and useful information for comparing with neutronics calculations of 6Li burnup in tritium breeding materials but are difficult to quantify experimentally. This paper reports demonstrated success in using the ion beam analysis technique Elastic Recoil Detection (ERD) to measure the 6Li fraction in LiAlO2 pellets. This technique utilized a 42 MeV Si7+ ion beam to recoil the light isotopes into a detector telescope that separated each isotope by simultaneously measuring the energy and stopping power of these recoils. This technique was used to accurately measure the enriched 6Li/Li-total of 0.25 ± 0.02, compared to the known value of 0.239. The isotopes 1H, 2H, and 4He were also measured.
Image navigation and registration for the geostationary lightning mapper (GLM) (2016)

The Geostationary Lightning Mappers (GLM) for the Geostationary Operational Environmental Satellite (GOES) GOES-R series will, for the first time, provide hemispherical lightning information 24 hours a day from longitudes of 75 and 137 degrees west. The first GLM of a series of four is planned for launch in November, 2016. Observation of lightning patterns by GLM holds promise to improve tornado warning lead times to greater than 20 minutes while halving the present false alarm rates. In addition, GLM will improve airline traffic flow management, and provide climatology data allowing us to understand the Earth’s evolving climate. The paper describes the method used for translating the pixel position of a lightning event to its corresponding geodetic longitude and latitude, using the J2000 attitude of the GLM mount frame reported by the spacecraft, the position of the spacecraft, and the alignment of the GLM coordinate frame relative to its mount frame. Because the latter alignment will experience seasonal variation, this alignment is determined daily using GLM background images collected over the previous 7 days. The process involves identification of coastlines in the background images and determination of the alignment change necessary to match the detected coastline with the coastline predicted using the GSHHS database. Registration is achieved using a variation of the Lucas-Kanade algorithm where we added a dither and average technique to improve performance significantly. An innovative water mask technique was conceived to enable self-contained detection of clear coastline sections usable for registration. Extensive simulations using accurate visible images from GOES13 and GOES15 have been used to demonstrate the performance of the coastline registration method, the results of which are presented in the paper.
Genipin-Crosslinked Donor Sclera for Posterior Scleral Contraction/Reinforcement to Fight Progressive Myopia (2018)

PSCR with genipin-crosslinked sclera is safe and effective to restrain eye globe elongation in young patients within a 2- to 3-year follow-up period.
A novel family of layered double hydroxides—[MAl4(OH)12](NO3)2·xH2O (M = Co, Ni, Cu, Zn) (2004)

A class of layered double hydroxides with the layer composition [MAl4(OH)12](NO3)2·xH2O, where M = Zn, Cu, Ni and Co, has been synthesised for the first time and its anion exchange chemistry explored. These materials are related to the minerals chalcoalumite, mbobomkulite and nickelalumite (see M. Fleischer, R. G. Burns, L. J. Cabri, C. A. Francis and A. Pabst, Am. Miner., 1982, 67, 413).
Factors Related to Radiation Exposure during Lumbar Spine Intervention (2016)

Fluoroscopy guidance is useful to confirm anatomical landmark and needle location for spine intervention; however, it can lead to radiation exposure in patients, physicians, and medical staff. Physicians who used fluoroscopy should be cognizant of radiation exposure and intend to minimize radiation dose. We retrospectively reviewed three lumbar spine intervention procedures (nerve root block, medial branch block, and facet joint block) at our institution between June and December, 2014. We performed 268 procedures on 220 patients and found significant difference in radiation dose between two groups classified by performing physicians. The physician who controlled the fluoroscopy unit directly used significantly shorter fluoroscopy (6 seconds) that resulted in a smaller radiation dose (dose area product [DAP] 0.59 Gy∙cm(2)) than the physician supervising the radiographer controlling the fluoroscopy unit (72 seconds, DAP 5.31 Gy∙cm(2), P < 0.001). The analysis indicates that the difference in fluoroscopy time depends on whether a physician or a radiographer controls the fluoroscopy unit.
Far-Infrared Absorption in Superconducting Lanthanum (1964)

Measurements have been made of far-infrared absorption in pure, face-centered cubic, superconducting lanthanum at 1.3\ifmmode^\circ\else\textdegree\fi{}K. The results indicate a gap width $2\ensuremath{\Delta}=12.0\ifmmode\pm\else\textpm\fi{}1.0$ ${\mathrm{cm}}^{\ensuremath{-}1}$. In terms of the measured value of the critical temperature, ${T}_{c}=6.06\ifmmode^\circ\else\textdegree\fi{}$K, $2\ensuremath{\Delta}=2.85\ifmmode\pm\else\textpm\fi{}0.24k{T}_{c}$. The data indicate the possible presence of a small amount of structure in the absorption curve at an energy about twice the gap width. These results are compared with theoretical predictions which have been made recently from a proposed new mechanism for superconductivity in lanthanum.
Agile assembly architecture: an agent based approach to modular precision assembly systems (2002)

This paper presents our initial thoughts on the design of an architecture for highly flexible, modular, and distributed precision assembly systems. Through the use of a unified design, simulation, programming, and monitoring environment coupled with self-representing cooperative agents, this architecture will significantly simplify the process of factory design and deployment. Our demonstration of this architecture takes the form of a table top sized assembly system targeted at the partial assembly of high-density magnetic storage devices.
Uniformly defined descending sequences of degrees (1976)

This paper answers some questions which naturally arise from the Spector-Gandy proof of their theorem that the π 1 1 sets of natural numbers are precisely those which are defined by a Σ 1 1 formula over the hyperarithmetic sets. Their proof used hierarchies on recursive linear orderings ( H -sets) which are not well orderings. (In this respect they anticipated the study of nonstandard models of set theory.) The proof hinged on the following fact. Let e be a recursive linear ordering. Then e is a well ordering if and only if there is an H -set on e which is hyperarithmetic. It was implicit in their proof that there are recursive linear orderings which are not well orderings, on which there are H -sets. Further information on such nonstandard H -sets (often called pseudohierarchies) can be found in Harrison [4]. It is natural to ask: on which recursive linear orderings are there H -sets? In Friedman [1] it is shown that there exists a recursive linear ordering e that has no hyperarithmetic descending sequences such that no H -set can be placed on e . In [1] it is also shown that if e is a recursive linear ordering, every point of which has an immediate successor and either has finitely many predecessors or is finitely above a limit point (heretofore called adequate ) such that an H -set can be placed on e , then e has no hyperarithmetic descending sequences. In a related paper, Friedman [2] shows that there is no infinite sequence x n of codes for ω-models of the arithmetic comprehension axiom scheme such that each x n + 1 is a set in the ω-model coded by x n , and each x n +1 is the unique solution of P ( x n , x n +1 ) for some fixed arithmetic P .
54.1: Invited Paper : Human Factors of Stereoscopic Displays (2009)

Abstract This paper provides a review of human factors issues that arise when designing stereoscopic displays. Issues discussed include: (1) basics of human stereopsis; (2) interocular cross talk; (3) distance scaling of disparity information; (4) accommodative‐vergence mismatch; (5) stereoanomly; (6) intuitive reasoning. The paper concludes with several recommendations.
ChemInform Abstract: 1ALPHA‐HYDROXYVITAMIN D2, A POTENT SYNTHETIC ANALOG OF VITAMIN D2 (1975)

Abstract Aus Isoergosteron wird über verschiedene Zwischenstufen durch Selendioxid‐Oxidaa tion, Behandeln mit H 2 O 2 , Lithiumaluminiumhydridreduktion, Acetylierung, allylische Bromierung, Dehydrobromierung, UV‐Bestrahlung und abschließende Hydrolyse das la‐Hydroxyvitamin D2 (I) synthetisiert.
Smooth Surface Constructions via a Higher-Order Level-Set Method (2007)

We present a general framework for a higher-order spline level-set (HLS) method and apply this to smooth surface constructions. Starting from a first order energy functional, we obtain a general level set formulation of geometric partial differential equation, and provide an efficient approach to solve this partial differential equation using a C <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> spline basis. We also present a fast cubic spline interpolation algorithm based on convolution and the Z-transform, which exploits the local relationship of interpolatory cubic spline coefficients with respect to given function data values. We provide two demonstrative smooth surface construction examples of our HLS method. The first is the construction of a smooth surface model (an implicit solvation interface) of bio-molecules in solvent, given their individual atomic coordinates and solvated radii. The second is the smooth surface reconstruction from a cloud of points generated from a 3D surface scanner.
Halophenyl Furanopyrimidines as Potent and Selective Anti-VZV Agents (2003)

Bicyclic furano pyrimidines have been previously reported by us to be highly potent and selective inhibitors of varicella zoster virus (VZV). p-Alkyl phenyl analogues are particularly potent with EC50 values below 1 nM. In this article we report the synthesis and anti-VZV activity of a series of halophenyl analogues, with variation in the nature (F, Cl, Br) and location (o, m, p) of the halogen substituent. The compounds show a range of activities from ca. 10 nM to > 50 microM. In most cases, ortho substitution leads to greatest activity, meta substitution is in general poor, and the effect of p-substitution shows a marked dependence on the halogen atom. The p-fluorophenyl compound is unique amongst compounds of this class in being inactive as an antiviral. The possible origins of these marked SARs are discussed.
Silene nivea (Nutt.) Muhl. ex Otth (2006)

https://thekeep.eiu.edu/herbarium_specimens_byname/17229/thumbnail.jpg
Dopamine-Modified Alginate Beads Reinforced by Cross-Linking via Titanium Coordination or Self-Polymerization and Its Application in Enzyme Immobilization (2013)

Two novel kinds of dopamine-modified alginate beads were developed by using titanium(IV) coordination or self-polymerization, besides the conventional Ca2+ ion cross-linking. Alginate was modified with dopamine (AlgDA) via EDC/NHS chemistry. Fourier transform infrared spectroscopy (FTIR) and circular dichroism (CD) characterization confirmed that dopamine was covalently attached preferentially to the mannuronic acid residues of alginate; thus, gel-forming ability of the as-prepared AlgDA was well retained. The titanium(IV) coordination-reinforced alginate beads [Ca–Ti(AlgDA)] were prepared by cross-linking with Ti4+ and Ca2+. Covalently cross-linking-reinforced alginate beads (Ca–AlgPDA) were also prepared by self-polymerization of dopamine and cross-linking with Ca2+. The swelling of Ca–AlgPDA and Ca–Ti(AlgDA) were both obviously inhibited, and the mechanical properties were enhanced by 3 times compared to those of Ca–Alg beads. The as-prepared beads were utilized for immobilization of alcohol dehydrogenase (YADH). The immobilization efficiency of Ca–Ti(AlgDA) and Ca–AlgPDA reached up to 100% and 89%, respectively, both notably higher than that of Ca–Alg (67.4%). Stabilities of the immobilized YADH in Ca–AlgPDA and Ca–Ti(AlgDA) toward pH, storage, and recycling were all improved compared with those immobilized in Ca–Alg.
Evaluation of solar cell materials for a Solar Power Satellite (1980)

Alternative solar cell materials being considered for the solar power satellite are described and price, production, and availability projections through the year 2000 are presented. The chief materials considered are silicon and gallium arsenide.
Purification to homogeneity of a human hematopoietic growth factor that stimulates the growth of a murine interleukin 3-dependent cell line. (1986)

A human lymphokine derived from the 5637 bladder carcinoma has been purified to homogeneity by using sequential reverse-phase high pressure liquid chromatography. A high recovery of biological activity is obtained by using this purification. The NH2-terminal amino acid sequence shows no homology to human interleukin 1 (IL 1), human IL 2, murine IL 3, or human granulocyte-macrophage colony-stimulating factor. The growth-promoting properties of the 5637-derived factor can be rapidly assayed by using the murine IL 3-dependent 32D c1-23 cell line. The amino acid sequence described is identical to that recently described for a human granulocyte colony-stimulating factor.
Functionalization of polypropylene nonwoven by DBD and DCSBD plasma mediated silver and gold deposition (2012)

This work is supported by the Ministry of Education and Science of the Republic of Serbia (Projects OI 171034 and OI 172029).