gebhart/patrepeval huggingface dataset:
Sulforaphane-assisted preparation of tellurium flower-like nanoparticles (2019)

A new method for the fabrication of flower-like tellurium nanoparticles is reported. It is based on the reduction of tellurite precursor by products generated during decomposition of sulforaphane at elevated temperature in aqueous medium. These species and other organic molecules present in the reaction mixture are being adsorbed on the surface of tellurium nuclei and govern further tellurium growth in the form of nanoflowers. The obtained particles have been characterized by a range of physicochemical techniques. It was shown that the average size of the nanoflower particles is ca. 112 nm, and they are composed of smaller domains which are ca. 30 nm in diameter. The domains are crystalline and consist of trigonal tellurium as shown by x-ray diffraction, Raman spectroscopy and high resolution transmission electron microscopy. The tellurium nanoflowers were examined from the perspective of their potential anticancer activity. The in vitro cell viability studies were conducted on breast cancer (MDA-MB-231, MCF-7) and normal cell lines (MCF-10A) employing MTT and CVS assays. It was shown, that the nanoflowers exhibit considerable cytotoxicity against cancer cells which is ca. 3-7 times higher than that observed for reference normal cells. The preliminary in vivo investigations on rats revealed that the nanoflowers accumulate predominantly in pancreas after intraperitoneal administration, without observable negative behavioral effects.
Epstein-Barr virus-associated nephrotic syndrome (2012)

Acute infection with Epstein-Barr virus (EBV) causes fever, fatigue and pharyngitis. Renal involvement in systemic EBV infections typically manifests as acute tubular necrosis or tubulointerstitial nephritis. Rarely, EBV infection causes nephrotic syndrome due to minimal change disease. A 22-year-old male with infectious mononucleosis (IM) presented with nephrotic syndrome. Renal biopsy showed minimal change disease with diffuse foot process effacement of the podocytes. Treatment with methylprednisone led to rapid and complete clinical remission. Minimal change nephropathy is a very rare manifestation of EBV infection and should be considered in patients with IM and proteinuria.
Direct Observation of Surface Chemistry Using Ultrafast Soft-X-Ray Pulses (2001)

We present the first demonstration of the use of ultrafast extreme-ultraviolet pulses to directly monitor a surface chemical reaction on femtosecond time scales. By adsorbing molecular oxygen onto a platinum surface and exciting it with an ultrafast laser pulse, changes in the oxygen-platinum chemical bond on a subpicosecond time scale were observed through changes in the photoelectron spectra. This work demonstrates a powerful new technique for studying reactions of interest in catalysis and for probing changes of local order on surfaces on their fundamental time scales.
Balancing Nonsense Mutation Readthrough and Toxicity of Designer Aminoglycosides for Treatment of Genetic Diseases (2023)

New derivatives of aminoglycosides with a side chain 1,2-aminoalcohol at the 5" position of ring III were designed, synthesized, and biologically evaluated. The novel lead structure (compound <b>6</b>), exhibiting substantially enhanced selectivity toward eukaryotic versus prokaryotic ribosome, high readthrough activity, and considerably lower toxicity than the previous lead compounds, was discovered. Balanced readthrough activity and toxicity of <b>6</b> were demonstrated in three different nonsense DNA-constructs underlying the genetic diseases, cystic fibrosis and Usher syndrome, and in two different cell lines, baby hamster kidney and human embryonic kidney cells. Molecular dynamics simulations within the A site of the 80S yeast ribosome demonstrated a remarkable kinetic stability of <b>6</b>, which potentially determines its high readthrough activity.
Diagnosing Idiopathic Normal-pressure Hydrocephalus (2005)

It is recommended that INPH be classified into probable, possible, and unlikely categories. We hope that these criteria will be widely applied in clinical practice and will promote greater consistency in patient selection in future clinical investigations involving INPH.
A fully automated high-performance liquid chromatographic procedure for isolation and purification of Amadori compounds (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA fully automated high-performance liquid chromatographic procedure for isolation and purification of Amadori compoundsNicole Moll, Bernard Gross, That Vinh, and Manfred MollCite this: J. Agric. Food Chem. 1982, 30, 4, 782–786Publication Date (Print):July 1, 1982Publication History Published online1 May 2002Published inissue 1 July 1982https://pubs.acs.org/doi/10.1021/jf00112a043https://doi.org/10.1021/jf00112a043research-articleACS PublicationsRequest reuse permissionsArticle Views186Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Synthetische Vakzine aus tumorassoziierten MUC1‐Glycopeptidantigenen und einem T‐Zellepitop für die Induzierung einer hochspezifischen humoralen Immunantwort (2008)

Selektive Impfreaktion: Die gezeigte, vollsynthetische Vakzine mit einem Glycopeptidantigen aus dem tumorassoziierten Mucin MUC1 und einem immunstimulierenden T-Zellepitop aus Ovalbumin (R1, R2=H, TN) löst in transgenen Mäusen eine hochspezifische humorale Immunantwort aus. Der induzierte Antikörper reagiert nur mit dem Glycopeptidantigen selbst und mit Analoga, die weitere tumorassoziierte TN-Antigen-Monosaccharide in der gleichen Peptidsequenz tragen.
Endogenous bacterial flora in pregnant women and the influence of maternal genetic variation (2010)

Preterm labour, premature prelabour rupture of membranes and low birth weight have all been associated with either specific maternal genital tract infections or an altered vaginal microflora during pregnancy. Factors that influence the variation in microbial-host interaction play an important role in individual susceptibility to adverse pregnancy outcomes. The innate immune responses at mucosal surfaces play a crucial role against microbial invasion. Multiple genes are responsible for the regulation of the innate immune system. Genetic polymorphisms that disrupt innate immune recognition or the responses to infectious microorganisms could explain the alterations in microflora and individual susceptibility to pregnancy complications.
Gestación por Sustitución y Licencias por Maternidad/Paternidad: La Agenda de Cuidado a la Luz de la Jurisprudencia Española y la Perspectiva Argentina (2017)

espanolEl presente articulo busca analizar la posibilidad de acceder a una (co)maternidad / (co)paternidad mediante tecnicas de reproduccion humana asistida (TRHA), incluida la gestacion por sustitucion (GS), en conjunto con la problematica de la agenda de cuidado y las licencias por maternidad/paternidad, partiendo del hecho cierto de la GS se realiza, sin detenerse en los argumentos a favor y en contra de ella. Asi, revisa el marco normativo argentino en relacion a la GS y las licencias por maternidad/paternidad a la luz de la reciente jurisprudencia espanola que ha otorgado y rechazado licencias en casos en que se tuvo hijos/as mediante la GS, teniendo en cuenta teniendo en cuenta la perspectiva de genero, como es el uso del tiempo en cada familia, como las TRHA y el cuidado impactan diferencialmente sobre la mujer y como se traduce esta situacion cuando se trata de familias compuestas por dos padres varones. EnglishThis paper aims to analyze the new technologies and the ability to access a (co)Maternity / (co)Fatherhood through assisted reproductive technics (ART), including surrogate motherhood, altogether with the issue of the care work and maternity/paternity leave. Therefore, this article aims no to stop in the arguments for and against surrogate motherhood (SM), but to reflect about how maternity / paternity leaves must be interpreted in these cases. For that purpose, the article analyzes Argentinian SM and parental leave legal situation in the light of recent Spanish jurisprudence that have authorized maternity / paternity leave in cases of children born by SM while, while considering gender issues involved in this situations, how is the use of time in each family, how both ART and care work have a differential impact on women, and what happens when it comes to families consisting of two male parents.
Biodegradable greases (1994)

Describes the requirements for biodegradability, defines the different terms and lists the various tests used. Outlines how greases can cause pollution. Details the main primary biodegradability test for lubricants and how to formulate greases to optimize breakdown in the environment and still lubricate well. Gives examples of commercial biodegradable greases.
Assessment of Hip and Knee Joints and Implants Using Acoustic Emission Monitoring: A Scoping Review (2020)

Objectives: Population ageing and the subsequent increase of joint disorders prevalence requires the development of non-invasive and early diagnostic methods to enable timely medical assistance and promote healthy aging. Over the last decades, acoustic emission (AE) monitoring, a technique widely used in non-destructive testing, has also been introduced in orthopedics as a diagnostic tool. This review aims to synthesize the literature on the use of AE monitoring for the assessment of hip and knee joints or implants, highlighting the practical aspects and implementation considerations. Methods: this review was conducted as per the PRISMA statement for scoping reviews. All types of studies, with no limits on date of publication, were considered. Articles were assessed and study design parameters and technical characteristics were extracted from relevant studies. Results: conducted search identified 1379 articles and 64 were kept for charting. Seven additional articles were added at a later stage. Reviewed works were grouped into studies on joint condition assessment, implant assessment, and hardware or software development. Native knees and hip implants were most commonly assessed. The most researched conditions were osteoarthritis, implant loosening or squeaking in vivo and structural damage of implants in vitro. Conclusion: in recent years, AE monitoring showed potential of becoming a useful diagnostic tool for lower limb pathologies. However, further research is needed to refine the existing methods and assess their feasibility in early diagnostics. Significance: The current state of research on AE monitoring for hip and knee joint assessment is described and future research directions are identified.
Radio frequency spectrum analyzer based on spectral hole burning: experimental progress and future steps (2004)

We report on spectral-hole-burning-based instantaneous spectral analysis of optically carried broadband radio frequency signals. We have demonstrated 100-channel operation over 3.3 GHz bandwidth. We discuss future steps towards 10 GHz bandwidth and 1000-channel operation.
Supplementary Table S9 from Transcriptome Analysis of Recurrently Deregulated Genes across Multiple Cancers Identifies New Pan-Cancer Biomarkers (2023)

&lt;p&gt;Gene level overlap between differentially expressed, protein-coding genes from the FANTOM5 analysis, the TCGA in-house analysis and the TCGA analysis by Cabanski at al. and Zhang at al.&lt;/p&gt;
Quantitative Anti-HBc in Liver Pathological States in Patients with Chronic Hepatitis B Virus Infection (2019)

Following hepatic aggravation of necroinflammation and progression of fibrosis, anti-HBc increases gradually in HBeAg-positive patients and continues to increase gradually in HBeAg-negative patients, which is a useful but unsatisfactory marker for monitoring pathological states.
Development of a disease-specific measure of quality of life in myelodysplastic syndromes (MDS): The “QUALMS-1”. (2012)

6103 Background: Studies assessing the quality of life (QoL) experienced by patients with MDS have almost universally relied upon generic measures; however, disease-specific QoL tools can allow for more sensitive assessments of the impact of changes in disease status. Methods: Using a clinical impact method of instrument development, individual and combined focus groups were conducted with 32 members of our institution’s MDS community (patients, their caregivers, and health care providers) to identify MDS-relevant QoL domains and associated question topics. Participants’ rankings of the importance of the domains and question topics were compared, collapsing patients/caregivers into one group and physicians/other providers into another. A draft scale was constructed taking a greater number of questions from the more highly-ranked domains. Results: “Fatigue” was ranked as the most important domain (see table). None of the 12 domains were ranked significantly differently by patients/caregivers versus providers. The two groups ranked 5 of 60 question topics differently: “Too tired for routine tasks” (providers higher; p= .05); “limited availability of support beyond the family” (providers higher; p= .02); “organizing life around transfusion/MD appointments” (providers higher, p= .03); “bruising” (patients/caregivers higher, p= .05) and “anger over diagnosis” (providers higher, p= .03). Conclusions: A high level of agreement in the rankings of domains and question topics between MDS patients/caregivers and providers suggests that the QoL experience of MDS patients is consistently compromised. The resulting 38-item draft QUALMS-1 tool is now being piloted (cognitive debriefing and behavioral coding) in a new cohort of MDS patients, with the ultimate goal of validation in a multi-institutional setting. [Table: see text]
Maintenance of neuronal size gradient in MNTB requires sound-evoked activity (2016)

The medial nucleus of the trapezoid body (MNTB) is an important source of inhibition during the computation of sound location. It transmits fast and precisely timed action potentials at high frequencies; this requires an efficient calcium clearance mechanism, in which plasma membrane calcium ATPase 2 (PMCA2) is a key component. Deafwaddler (<i>dfw</i><sup><i>2J</i></sup> ) mutant mice have a null mutation in PMCA2 causing deafness in homozygotes (<i>dfw</i><sup><i>2J</i></sup> /<i>dfw</i><sup><i>2J</i></sup> ) and high-frequency hearing loss in heterozygotes (+/<i>dfw</i><sup><i>2J</i></sup> ). Despite the deafness phenotype, no significant differences in MNTB volume or cell number were observed in <i>dfw</i><sup><i>2J</i></sup> homozygous mutants, suggesting that PMCA2 is not required for MNTB neuron survival. The MNTB tonotopic axis encodes high to low sound frequencies across the medial to lateral dimension. We discovered a cell size gradient along this axis: lateral neuronal somata are significantly larger than medially located somata. This size gradient is decreased in +/<i>dfw</i><sup><i>2J</i></sup> and absent in <i>dfw</i><sup><i>2J</i></sup> /<i>dfw</i><sup><i>2J</i></sup> The lack of acoustically driven input suggests that sound-evoked activity is required for maintenance of the cell size gradient. This hypothesis was corroborated by selective elimination of auditory hair cell activity with either hair cell elimination in Pou4f3 DTR mice or inner ear tetrodotoxin (TTX) treatment. The change in soma size was reversible and recovered within 7 days of TTX treatment, suggesting that regulation of the gradient is dependent on synaptic activity and that these changes are plastic rather than permanent.<b>NEW & NOTEWORTHY</b> Neurons of the medial nucleus of the trapezoid body (MNTB) act as fast-spiking inhibitory interneurons within the auditory brain stem. The MNTB is topographically organized, with low sound frequencies encoded laterally and high frequencies medially. We discovered a cell size gradient along this axis: lateral neurons are larger than medial neurons. The absence of this gradient in deaf mice lacking plasma membrane calcium ATPase 2 suggests an activity-dependent, calcium-mediated mechanism that controls neuronal soma size.
Total-Dose and Dose-Rate Dependence of Proton Damage in MOS Devices during and after Irradiation (1984)

Rad-hard CMOS/Bulk inverters with input gates high and low were irradiated by protons with a nominal energy of 8 MeV. The purpose of this study was to determine the total-dose and doserate dependence of threshold voltage shifts, both during and immediately after irradiation and over extended periods of time thereafter. Post-rad bias conditions were the same as during bombardment. The results suggest that previous measurements [1, 2], which indicated that post irradiation changes of voltage shifts depended on type of radiation source and on energy of particles, were essentially due to the unique combinations of total dose and dose rate applied in those experiments. It now appears, that all of the damage effects observed in the previous experiments for the various sources and energies, during and after irradiation, could be simulated by selected equivalent doses and dose rates with any radiation source or particle energy. The importance of this conclusion is that a key relationship of Co60 damage effects to those from any other radiation source could be experimentally determined in terms of total dose and dose rate alone. Consequently, a valid simulation of specific charged particle and energy effects of the space radiation environment may be accomplished on the ground with appropriately designed Co60 tests.
Visualization of Atomic Processes on Ruthenium Dioxide using Scanning Tunneling Microscopy (2004)

The visualization of surface reactions on the atomic scale provides direct insight into the microscopic reaction steps taking place in a catalytic reaction at a (model) catalyst's surface. Employing the technique of scanning tunneling microscopy (STM), we investigated the CO oxidation reaction over the RuO2(110) and RuO2(100) surfaces. For both surfaces the protruding bridging O atoms are imaged in STM as bright features. The reaction mechanism is identical on both orientations of RuO2. CO molecules adsorb on the undercoordinated surface Ru atoms from where they recombine with undercoordinated O atoms to form CO2 at the oxide surface. In contrast to the RuO2(110) surface, the RuO2(100) surface stabilizes also a catalytically inactive c(2 x 2) surface phase onto which CO is not able to adsorb above 100 K. We argue that this inactive RuO2(100)-c(2 x 2) phase may play an important role in the deactivation of RuO2 catalysts in the electrochemical Cl2 evolution and other heterogeneous reactions.
In vivo Study of Artemisinin and Its Derivatives against Primary Amebic Meningoencephalitis Caused by Naegleria fowleri (1995)

Artemisinin and its derivatives, beta-arteether and sodium artesunic acid, have been evaluated for activity against experimental primary amebic meningoencephalitis and the efficacy of these compounds has been compared with that of the standard drug amphotericin B. In vivo experiments in Swiss mice have shown that amphotericin B at a dose of 2.5 mg/kg for 5 days produced 100% protection in the mice infected intranasally with Naegleria fowleri. Artemisinin, beta-arteether, and sodium artesunic acid, even when tested at high doses (60-180 mg/kg x 5 days), were not curative and showed only slight protection as indicated by extension of mean survival time.
Functional Properties of Vinegar (2014)

A variety of natural vinegar products are found in civilizations around the world. A review of research on these fermented products indicates numerous reports of health benefits derived by consumption of vinegar components. Therapeutic effects of vinegar arising from consuming the inherent bioactive components including acetic acid, gallic acid, catechin, ephicatechin, chlorogenic acid, caffeic acid, p-coumaric acid, and ferulic acid cause antioxidative, antidiabetic, antimicrobial, antitumor, antiobesity, antihypertensive, and cholesterol-lowering responses. The aims of this article are to discuss vinegar history, production, varieties, acetic acid bacteria, and functional properties of vinegars.
3D vision on the parallel machine CAPITAN (2003)

Presents the implementation of a 3D segment based reconstruction process on Capitan, a parallel architecture machine developed and produced by MATRA. The process presented involves low and intermediate vision algorithms and is able to build a 3D segment based representation of an observed scene in less than 40 seconds. The hardware configuration of the parallel machine. Capitan for such applications and the parallelization of the algorithms required are presented. Some experimental results will be shown.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
An overview of computer vision (1982)

Computer Visionvisual perception employing computersshares with "Expert Systems" the role of being one of the most popular topics in Artificial Intelligence today.
Free Vibration and Stability Analysis of Internally Damped Rotating Shafts With General Boundary Conditions (1998)

Vibration analysis of an internally damped rotating shaft, modeled using Timoshenko beam theory, with general boundary conditions is performed analytically. The equations of motion including the effects of internal viscous and hysteretic damping are derived. Exact solutions for the complex natural frequencies and complex normal modes are provided for each of the six classical boundary conditions. Numerical simulations show the effect of the internal damping on the stability of the rotor system.
Noninvasive Fluorescent Identification of Bacteria Causing Acute Otitis Media in a Chinchilla Model (2000)

We were able to establish a prototype method for the noninvasive identification of a limited library of pathogens in a chinchilla model of acute otitis media.
An Optical Sealed Disk Assembly (1983)

The substrate around which the Sealed Disk Assembly (SDA) is developed is a web similar in some respects to those upon which photographic emulsions are coated. As with other substrates for optical disks, before the sensitive recording layers are applied, a surfacing treatment is given to provide extraordinary smoothness. Coatings placed upon properly prepared webs having suitable initial characteristics are equal in quality to those put on glass disks or on aluminum disk substrates, and have defect levels low enough to support optical digital data storage and retrieval applications.