gebhart/patrepeval huggingface dataset:
Transgenic mice rich in endogenous omega-3 fatty acids are protected from colitis (2006)

Omega-6 (n-6) and omega-3 (n-3) polyunsaturated fatty acids (PUFA) are the precursors of potent lipid mediators and play an important role in regulation of inflammation. Generally, n-6 PUFA promote inflammation whereas n-3 PUFA have antiinflammatory properties, traditionally attributed to their ability to inhibit the formation of n-6 PUFA-derived proinflammatory eicosanoids. Newly discovered resolvins and protectins are potent antiinflammatory lipid mediators derived directly from n-3 PUFA with distinct pathways of action. However, the role of the n-3 PUFA tissue status in the formation of these antiinflammatory mediators has not been addressed. Here we show that an increased n-3 PUFA tissue status in transgenic mice that endogenously biosynthesize n-3 PUFA from n-6 PUFA leads to significant formation of antiinflammatory resolvins and effective reduction in inflammation and tissue injury in colitis. The endogenous increase in n-3 PUFA and related products did not decrease n-6 PUFA-derived lipid mediators such as leukotriene B4 and prostaglandin E2. The observed inflammation protection might result from decreased NF-kappaB activity and expression of TNFalpha, inducible NO synthase, and IL-1beta, with enhanced mucoprotection probably because of the higher expression of trefoil factor 3, Toll-interacting protein, and zonula occludens-1. These results thus establish the fat-1 transgenic mouse as a new experimental model for the study of n-3 PUFA-derived lipid mediators. They add insight into the molecular mechanisms of inflammation protection afforded by n-3 PUFA through formation of resolvins and protectins other than inhibition of n-6 PUFA-derived eicosanoid formation.
Unexpected Doppler effects from microbubbles moving through an ultrasound beam (2003)

Encapsulated microbubbles crossing an ultrasound field are known to be sensitive to radiation force, i.e. they tend to move along the direction of the incident beam. In this paper, a simple simulation model is introduced and shown capable of predicting the displacements imposed to microbubbles when they simultaneously experience the ultrasound radiation force and the drag force of the fluid where they are suspended. Based on the total particle displacement estimated between consecutive transmitted pulses, Doppler spectra corresponding to different intensity levels were computed. They were then compared to the experimental spectra obtained in vitro by using Levovist ((R)Schering, Berlin, Germany) particles suspended in distilled water flowing at a steady rate. The excellent agreement between experimental and simulation results confirm the validity of the proposed model.
Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition (2015)

Cognitive dysfunction is a core feature of dementia and a prominent feature in psychiatric disease. As non-redundant regulators of intracellular cAMP gradients, phosphodiesterases (PDE) mediate fundamental aspects of brain function relevant to learning, memory, and higher cognitive functions. Phosphodiesterase-4B (PDE4B) is an important phosphodiesterase in the hippocampal formation, is a major Disrupted in Schizophrenia 1 (DISC1) binding partner and is itself a risk gene for psychiatric illness. To define the effects of specific inhibition of the PDE4B subtype, we generated mice with a catalytic domain mutant form of PDE4B (Y358C) that has decreased ability to hydrolyze cAMP. Structural modeling predictions of decreased function and impaired binding with DISC1 were confirmed in cell assays. Phenotypic characterization of the PDE4B(Y358C) mice revealed facilitated phosphorylation of CREB, decreased binding to DISC1, and upregulation of DISC1 and β-Arrestin in hippocampus and amygdala. In behavioral assays, PDE4B(Y358C) mice displayed decreased anxiety and increased exploration, as well as cognitive enhancement across several tests of learning and memory, consistent with synaptic changes including enhanced long-term potentiation and impaired depotentiation ex vivo. PDE4B(Y358C) mice also demonstrated enhanced neurogenesis. Contextual fear memory, though intact at 24 h, was decreased at 7 days in PDE4B(Y358C) mice, an effect replicated pharmacologically with a non-selective PDE4 inhibitor, implicating cAMP signaling by PDE4B in a very late phase of consolidation. No effect of the PDE4B(Y358C) mutation was observed in the prepulse inhibition and forced swim tests. Our data establish specific inhibition of PDE4B as a promising therapeutic approach for disorders of cognition and anxiety, and a putative target for pathological fear memory.
Novel Mechanical Device for Producing Rapidly Cooled Metals and Alloys of Uniform Thickness (1963)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Paul Pietrokowsky; Novel Mechanical Device for Producing Rapidly Cooled Metals and Alloys of Uniform Thickness. Rev. Sci. Instrum. 1 April 1963; 34 (4): 445–446. https://doi.org/10.1063/1.1718403 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioReview of Scientific Instruments Search Advanced Search |Citation Search
Morphological and structural adaptations to soft substrates in the Early Jurassic monomyarians Lithiotis and Cochlearites (1982)

Lithiotis problematica and Cochlearites loppianus are sessile monomyarian bivalves known from the Early Jurassic of the Tethyan region, where they are found standing vertically in the calcareous mud of lagoonal fades. Their shells are characterized by a long cardinal area, ventrally displaced body space, thick attached valve, and a thin, flat free valve of equal length. A functional ligament is present only in juvenile stages of Cochlearites. To grow straight, the ventral end of the shell had to gape, so in both species it was probably the elasticity of the thin free valve that caused the shell to open. In the adult stage the shell grew only towards the venter with an apparently constant growth rate, while the soft body size remained unchanged. The outer shell is composed of a compact aragonitic layer, while the inner part is filled with loose chalky deposits which are thought to have functioned as supporting the soft body and lifting it upwards. These and other morphologic and structural features, as well as the growth pattern, can be explained as an adaptation of a sessile animal to soft muddy bottoms and rapid sedimentation. Some elongated Crassostrea living in similar environments show remarkable morphologic and structural convergence with Lithiotis and Cochlearites.
Analysis of thermal noise spike cancellation (1975)

Thermally induced voltage pulses have been reported by Gorter et al. in the output of magneto-resistive reading heads. To reduce this thermal noise, Gorter et al. added a second magnetoresistive element on the same substrate but with a large head-to-tape distance. The outputs of these two stripes are differentially amplified to reject common mode noise. A theoretical analysis is made of the heat flow in magnetoresistive heads due to frictional heat generated at the head/tape interface. This model predicts that the dual stripe geometry will be effective for thermal noise cancellation only for low tape velocity or low thermal noise frequency and/or high thermal diffusivity substrate/cover material for the magnetoresistive elements. This result is also expected to be qualitatively valid for thermal noise due to intermittent cooling by the tape of Joule heat generated in the magneto-resistive elements.
Chiral Dinuclear Vanadium Complexes Catalyzed Oxidative Coupling of 2-Naphthols (2008)

Two new chiral dinuclear vanadium(V) catalysts were prepared and characterized, which showed modest to good enantioselectivities for the oxidative coupling reactions of 2-naphthols to afford synthetically useful BINOL derivatives.
Identification of susceptibility loci at 7q31 and 9p13 for bipolar disorder in an isolated population (2009)

We performed a linkage analysis on 23 Finnish families with bipolar disorder and originating from the North-Eastern region of Finland, using the Illumina Linkage Panel IV (6K) Array with an average intermarker spacing of 0.65 cM across the genome. We detected genome-wide significant evidence for linkage of mood disorder (bipolar disorder type I, II, or not otherwise specified, manic type of schizoaffective psychosis, cyclothymia, or recurrent depression) to chromosomes 7q31 (LOD = 3.20) and 9p13.1 (LOD = 4.02). Analyzing the best markers on the complete set of 179 Finnish bipolar families supported the findings on chromosome 9p13 (maximum LOD score of 3.02 at position 383 Mb, immediately upstream of the centromere). This region harbors several interesting candidate genes, including contactin associated protein-like 3 (CNTNAP3) and aldehyde dehydrogenase 1 (ALDH1B1). For the 7q31 locus, only one extended pedigree and ten families originating from the same late settlement region in North-Eastern Finland provided evidence for linkage, suggesting that a gene predisposing to bipolar disorder is enriched in that region. Candidate genes of interest in this locus include potassium-voltage-gated channel, member 2 (KCND2) and calcium-dependent activator protein for secretion 2 (CADPS2). The loci on the centromeric region of 9p13 and the telomeric region of 7q31 may represent susceptibility loci for mood disorder in the Finnish population.
Post‐Assembly Modification of Protein Cages by Ubc9‐Mediated Lysine Acylation (2022)

Although viruses have been successfully repurposed as vaccines, antibiotics, and anticancer therapeutics, they also raise concerns regarding genome integration and immunogenicity. Virus-like particles and non-viral protein cages represent a potentially safer alternative but often lack desired functionality. Here, we investigated the utility of a new enzymatic bioconjugation method, called lysine acylation using conjugating enzymes (LACE), to chemoenzymatically modify protein cages. We equipped two structurally distinct protein capsules with a LACE-reactive peptide tag and demonstrated their modification with diverse ligands. This modular approach combines the advantages of chemical conjugation and genetic fusion and allows for site-specific modification with recombinant proteins as well as synthetic peptides with facile control of the extent of labeling. This strategy has the potential to fine-tune protein containers of different shape and size by providing them with new properties that go beyond their biologically native functions.
Heideggers Daseinsanalyse als Freundschaftslehre : Um die Miteinander-Befreiung (2012)

ハイデッガーの主著『存在と時間』(1927)は、その刊行当初から、他者の問題に関して重大な欠陥があると指摘され、繰り返し批判されてきた。それらに共通するのは、ハイデッガーは他者をもっぱら匿名的な「世人」、非本来的な現存在としてのみ見ており、他者は現存在の「本来性」からは締め出されている、という主張である。こうした批判が、その後の様々な他者論・倫理学の展開に寄与した、ということは周知であろう。だが近年、このような批判に抗し、ハイデッガーの他者論を積極的に見直そうとする動きがある。それらは総じて、ハイデッガーの議論の不十分さを認めつつも、そのなかに従来は看過されがちであった他者との本来的なかかわり方を探り出そうとする傾向にある。その際、一様に注目される概念が、『存在と時間』のなかで二度ほど語られた「率先的顧慮」という現存在のあり方である。「解放的」とも形容されるこの顧慮は、なるほど他者を世人支配から解放し、その独自な本来性に向けて自由にすると言われている以上、他者との本来的なかかわり方と言えるかもしれない。だがすでにレーヴィットが指摘しているように、この顧慮は一見すると他者への一方的な関係に留まっており、そこには共存在にとって本質的な「相互性」が欠落しているようにも見える。ただハイデッガー自身は、もちろん充実した議論には至っていないものの、この率先的顧慮のうちに「本来的な相互性」の存在を指摘している。率先的顧慮が他者の解放を目的とするものであるなら、この相互性はひとまず、「互いに解放し合う」という意味での「相互解放」と解することができよう。実は『存在と時間』の草稿にあたる『1925 年夏学期講義』のなかで、ハイデッガーはこうした「相互解放」について触れており、それを「友情」と呼んでいる。そうすると率先的顧慮における相互性の問題は、ある種の「友情論」として展開しうる余地が出てくると思われるが、管見では、この問題を十分な仕方で追究した研究はいまだ見受けられない。そこで本論は、『存在と時間』における相互性の問題を、友情論という観点から考察することを目指して、まずは率先的顧慮の規定を確認し (第一節)、つぎに他者の本来的な可能性の開示を「先駆的決意性」のなかに求める (第二節)。そして率先的顧慮の具体的なあり方を「友の声」と呼ばれる現象に即して明らかにすることにより (第三節) 、最終的には、相互解放としての友情の成立可能性を歴史的な「伝承」のうちに探ろうと思う (第四節)。本論の試みを通じて、ハイデッガーの思索のなかに世代を超えて通じ合う「友情」の新たな可能性を提示したい。
Progastrin processing differs in 7B2 and PC2 knockout animals: a role for 7B2 independent of action on PC2 (2001)

Cellular synthesis of neuroendocrine peptides requires prohormone convertases (PCs). In order to determine the role of PC2 for gastrin synthesis, we examined antral extracts from mice lacking PC2 or its chaperone, 7B2. The overall concentrations of precursors and alpha-amidated gastrins were similar in all mice. Chromatography, however, revealed that while the K(53)-K(54) site was almost fully cleaved in controls and half cleaved in PC2 null mice, only 23% was cleaved in 7B2 null mice. The results show that PC2 and 7B2 both are required for synthesis of the main form of gastrin (gastrin-17), and that 7B2 exhibits effects beyond PC2-mediated cleavages.
Reaktionen von Thalliumhalogeniden mit Dichlormonoxid und Ozon (1966)

Abstract TlBr reagiert in Br 2 ‐Lösung mit O 3 unter Bildung des bisher unbekannten, polymeren TlOBr, dessen Eigenschaften beschrieben werden. TlCl setzt sich mit Cl 2 O nur oberflächlich zu TlOCl um. In chloridhaltigen Lösungsmitteln (POCl 3 , HCl) reagiert O 3 mit TlCl zu Tl 4 Cl 6 , das nach dem IR‐Spektrum als Tl 3 [TlCl 6 ] aufzufassen ist. Demgegenüber erhält man aus Lösungen von TlCl 3 in POCl 3 mit Cl 2 O Thallium(III)‐dichlorophosphat, Tl(PO 2 Cl 2 ) 3 . Nach dem IR‐Spektrum ist das Thallium oktaedrisch von den drei chelatartig gebundenen O 2 PCl 2 ‐Gruppen umgeben.
Iterative space-time processing for multiuser detection in multipath CDMA channels (2002)

Space-time processing and multiuser detection are two promising techniques for combating multipath distortion and multiple-access interference in code division multiple access (CDMA) systems. To overcome the computational burden that rises very quickly with increasing numbers of users and receive antennas in applying such techniques, iterative implementations of several space-time multiuser detection algorithms are considered here. These algorithms include iterative linear space-time multiuser detection, Cholesky iterative decorrelating decision-feedback space-time multiuser detection, multistage interference canceling space-time multiuser detection, and expectation-maximization (EM)-based iterative space-time multiuser detection. A new space-time multiuser receiver structure that allows for efficient implementation of iterative processing is also introduced. Fully exploiting various types of diversity through joint space-time processing and multiuser detection brings substantial gain over single-receiver-antenna or single-user-based methods. It is shown that iterative implementation of linear and nonlinear space-time multiuser detection schemes discussed in this paper realizes this substantial gain and approaches the optimum performance with reasonable complexity. Among the iterative space-time multiuser receivers considered in this paper, the EM-based (SAGE) iterative space-time multiuser receiver introduced here achieves the best performance with excellent convergence properties.
Editors' Notes (2010)

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t(3;21)(q26;q22) with AML1 rearrangement in a de novo childhood acute monoblastic leukaemia (1996)

t(3;21)(q26;q22) is a recurrent chromosomal abnormality in Philadelphia-positive chronic myeloid leukaemia in blast crisis and in treatment-related myelodysplastic syndrome and acute myeloid leukaemia. The molecular consequences of the t(3;21) are presently being unravelled; various transcripts between the AML1 gene in 21q22 and several unrelated genes, i.e. EAP, EVI1 and MDS1, in 3q26 are generated, resulting in the formation of a chimaeric transcription factor. The t(3;21) has only rarely been described in de novo leukaemias and never before in an acute leukaemia in a child. We here present the clinical, cytogenetic and molecular genetic findings in a boy with a de novo acute monoblastic leukaemia with t(3;21)(q26;q22) and AML1 rearrangement.
Endocytosis and degradation of interstitial retinol-binding protein: differential capabilities of cells that border the interphotoreceptor matrix. (1985)

Between the pigment epithelium and the outer limiting membrane of the retina is an extracellular compartment filled with the interphotoreceptor matrix (IPM). A prominent component of the IPM is a glycoprotein known as interstitial retinol-binding protein (IRBP). Using in vitro techniques, we compared the ability of the cells that border this compartment to internalize colloidal gold (CG) coated with either IRBP or ovalbumin, a glycoprotein not found in the IPM. Neither IRBP-CG nor ovalbumin-CG was internalized by the Muller's cells. Both rod and cone photoreceptors take up IRBP-CG, which is observed in small vesicles and multivesicular bodies. Neither photoreceptor type takes up ovalbumin-CG. Acid phosphatase cytochemistry indicates that acid phosphatase reaction product in the multivesicular bodies co-localizes with IRBP-CG, which suggests that this molecule is degraded by rod and cone photoreceptors and is not recycled. The pigment epithelium internalizes IRBP-CG and ovalbumin-CG, both of which remain in small cytoplasmic vesicles near the apical plasma membrane. There is no indication that vesicles that contain either IRBP-CG or ovalbumin-CG fuse with the lysosomal system in the pigment epithelial cells during the incubation.
A Versatile Surrogate Model of the Power Distribution Grid Described by a Large Number of Parameters (2023)

This paper aims to present a general-purpose Surrogate Model for the probabilistic analysis of power distribution grids with a large number of input parameters. The distinctive feature of the novel technique is the employment of the partial derivatives of output variables versus input parameters to tame the “curse of dimensionality” problem exhibited by prior surrogate model calculation techniques. The second important feature of the proposed Surrogate Model method is that it does not require any a priori assumption about the nature or statistical distribution of the input parameters. In fact, it can be applied whenever design parameters are deterministic variables as well as when they are uncertain and represented by continuous and/or discrete random variables. Relevant applications presented in the paper refer to the probabilistic analysis of the distribution grid in the presence of a large number of photovoltaic sources and electric vehicle charging stations.
Annotate your SGPLOT Graphs (2014)

The SG procedures provide you multiple plot statements to create many different kind of graphs. These plot statements can be used together in creative ways to build your graph. However, even with this ability to customize, there are times when you need more than what you can get using just the plot statements. You need a way to add custom information anywhere on the graph. With SAS 9.3, the SG procedures support the ability to annotate the graph using data set based information. This annotation functionality is designed in a way similar to the annotate facility available with the SAS/GRAPH procedures. There are a few differences and enhancements. If you already know annotation from SAS/GRAPH, or if you are new to it, this paper will show you how to add custom annotations to your graphs.
Voice Activity Detection With Array Signal Processing In The Wavelet Domain (2002)

Publication in the conference proceedings of EUSIPCO, Toulouse, France, 2002
AUTORADIOGRAPHIC DISPOSITION OF 14C‐CAFFEINE IN MALE, FEMALE, AND PREGNANT MICE (1985)

ABSTRACT The autoradiographic disposition of 14 C‐caffeine in 13.5‐day pregnant mice was compared to that present in virgin females and males. C57B1/6J mice each received [8‐ 14 C] caffeine ip at a dose of 18.5 mg/kg. At 0.33, 3, and 24 h after treatment, the mice were anesthetized with ether and frozen by immersion in dry ice/hexane. The mice were processed for whole‐body autoradiography by the Ullberg technique; this procedure does not allow thawing or contact with solvents. The early sacrifice periods, 0.33 and 3 h, revealed no significant differences among the three groups. Heavy sites of localization noted included the lacrimal glands, retinal and hair‐follicle melanocytes, olfactory epithelium, bile and urine. Even after 24 h, no major differences in heavy sites of retention were visible. The major sites of localization noted included the olfactory epithelium, centrilobular region of the liver, bronchi, trachea, bile, and urine. In the fetal compartment, there was a moderate level of retention observed in the yolk sac and fetal eye.
Revised Wind Chill Index (The Development of a New Wind Chill Temperature Chart) (2018)

It had been known for many years that the original wind chill temperature charts used by the weather services of Canada and the U.S. were flawed. This speaker applied modern heat transfer principles to the Antarctic research that was the basis for the original charts to demonstrate that the temperatures were much too cold. He then proposed an alternative model that would more accurately depict the effect of wind in cold weather on exposed skin. Media attention and an internet conference sponsored in Canada prompted the U.S. Weather Service to initiate a program to update their charts. This speaker and a Canadian researcher who worked with a similar approach were charged with developing a new chart. An algorithm was completed and the new chart was put into effect in Canada in October and in the U.S. in November, 2001.
A complete classification of three-dimensional algebras over ${\mathbb R}$ and ${\mathbb C}$ (2019)

We provide a complete classification of three-dimensional associative algebras over the real and complex number fields based on a complete elementary proof. We list up all the multiplication tables of the algebras up to isomorphism. We compare our results with those given by mathematicians in the 19th century.
The Chennai Pediatric Electrophysiology Symposium (TCPES 2010) Premature Ventricular Contractions and Non-sustained Ventricular Tachycardia: Association with Sudden Cardiac Death, Risk Stratification, and Management Strategies (2010)

Premature ventricular contractions (PVCs) and non-sustained ventricular tachycardia (NSVT) are frequently encountered and a marker of electrocardiomyopathy. In some instances, they increase the risk for sustained ventricular tachycardia, ventricular fibrillation, and sudden cardiac death. While often associated with a primary cardiomyopathy, they have also been known to cause tachycardia-induced cardiomyopathy in patients without preceding structural heart disease. Medical therapy including beta-blockers and class III anti-arrhythmic agents can be effective while implantable cardiac defibrillators (ICD) are indicated in certain patients. Radiofrequency ablation (RFA) is the preferred, definitive treatment in those patients that improve with anti-arrhythmic therapy, have tachycardia-induced cardiomyopathy, or have certain subtypes of PVCs/NSVT. We present a review of PVCs and NSVT coupled with case presentations on RFA of fascicular ventricular tachycardia, left-ventricular outflow tract ventricular tachycardia, and Purkinje arrhythmia leading to polymorphic ventricular tachycardia.
INVESTIGATION INTO THE QUALITY OF UV VARNISHING / LAKAVIMO ULTRAVIOLETINIU LAKU KOKYBĖS TYRIMAI (2012)

Varnishing quality and the gloss of lithographic prints on different papers and cardboards were evaluated using expertise rating. It was found that varnishing quality and gloss increase with grammage do not depend on the varnish grade (two grades were tested) and is the same for the paper and cardboard of the same grammage. Santrauka Ekspertiniu būdu ištirta ofsetinių atspaudų ant įvairių popieriaus ir kartono rūšių lakavimo ultravioletiniu (toliau – UV) laku bendroji kokybė ir blizgumas. Nustatyta, kad lakavimo kokybė ir blizgumas gerėja didėjant popieriaus gramatūrai, lakavimo kokybė nepriklauso nuo lako rūšies (tirtos dvi rūšys) ir tos pačios gramatūros popieriaus ir kartono yra vienoda.