gebhart/patrepeval huggingface dataset:
Perspectives for the use of collagen synthesis inhibitors as antifibrotic agents (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPerspectives for the use of collagen synthesis inhibitors as antifibrotic agentsGeorge C. FullerCite this: J. Med. Chem. 1981, 24, 6, 651–658Publication Date (Print):June 1, 1981Publication History Published online1 May 2002Published inissue 1 June 1981https://doi.org/10.1021/jm00138a001RIGHTS & PERMISSIONSArticle Views162Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-Alerts Get e-Alerts
Accumulation of cobalt, zinc and manganese by the estuarine green microalga Chlorella salina immobilized in alginate microbeads (1992)

This paper describes cobalt, zinc, and manganese accumulation by Chlorella salina immobilized in calcium alginate microbeads, investigated by use of the radioisotopes <sup>60</sup>Co, <sup>54</sup>Mn, and <sup>65</sup>Zn. A rapid biosorption of the metals to C. salina cell walls and the alginate matrix, which was independent of light, temperature, or the metabolic inhibitor CCCP, was followed by a slower energy-dependent phase of uptake. Under similar conditions, immobilized cells accumulated greater amounts of Co, Zn, or Mn than free cells due to an increased active phase of uptake. Accumulation was also dependent on cell density in the alginate beads, with a greater uptake of cobalt at the highest cell densities. Desorption of cobalt from loaded beads was increased by decreasing pH and increasing concentrations of the cations, probably due to exchange of cobalt bound to the cell wall/alginate matrix for H<sup>+</sup> or cations.
Oxygen Effect on Laser Crystallization of Sputtered a-Si Film on Plastic Substrate (2006)

We studied a-Si film deposited by rf sputtering as a precursor material for laser crystallization. The oxygen contents from 4.63 to 16.62 at. % was found in the fairly optimized a-Si films deposited by Xe sputtering. The oxygen gas incorporation increased the surface roughness and exacerbated the Si film agglomeration phenomenon during laser crystallization. The incorporated oxygen atoms in polycrystalline Si (poly-Si) film limit the grain growth of Si atoms below 50 nm.
Saponin and Sapogenol. VIII. Photochemical Cleavage of Glycoside Linkage in Saponin. (1). Photolysis of Some Saponins and Their Structural Features (1974)

In search of a new hydrolysis method of saponin, it has been found that ultraviolet irradiation is a convenient procedure for hydrolysis of some oleanane triterpenoid saponins resulting in liberation of their genuine sapogenols. The subsequent investigation on structure requirement for ready photolysis of glycoside linkage in saponin has revealed that an uronic acid moiety directly connected to the sapogenol is an essential constituent in the carbohydrate portion.
A Convolutional Neural Network Based Deep Learning Technique for Identifying Road Attributes (2018)

Automatic assessment of road safety and conditions is essential for improving road infrastructure and reducing fatalities on the roads. The current manual systems used for road safety not only in Australia but around the world are inefficient and prone to many errors. The major challenges are to accurately detect, segment and classify all road objects and also calculate the distance between the objects. Deep learning with a recent breakthrough has the ability to address such major challenges. In this paper, we propose a novel deep learning approach that can analyze video data and assess road safety and conditions. The specific aims are to develop a novel convolutional neural network based segmentation and classification technique for automatically identifying road attributes for Australian Road Assessment Program (AusRAP) and a novel proximity measurement technique for distance measurement between AusRAP attributes. The proposed approach has been evaluated on the roadside video data collected by the Queensland department of transport and main roads and the results are presented.
Extending SHAPES for SIMD Architectures (2018)

SIMD (Single Instruction, Multiple Data) instruction sets are ubiquitous on modern hardware, but rarely used in software projects. A major reason for this is that efficient SIMD code requires data to be laid out in memory in an unconventional manner, forcing developers to explicitly refactor their code and data structures in order to make use of SIMD.
Sustainable Solvent-Free Selective Oxidation of Benzyl Alcohol Using Ru(0) Supported on Alumina (2023)

The selective oxidation of primary alcohols into their corresponding carbonyl compounds is challenging because of the easy over oxidization to acids and esters. The traditional reaction requires large amounts of solvent and oxidant, causing serious environmental issues. Recently, several efforts have been made to transform the reaction into a more sustainable process. Here, we investigated the solvent-free oxidation of benzyl alcohol using air as a green oxidant in the presence of ruthenium supported on alumina and zirconia, thereby meeting atom economy and environmental requirements. The materials were extensively characterized and, in addition to their activity, selectivity, and reusability, the environmental sustainability of the process was assessed according to green chemistry metrics. XRD, TEM, and XPS analyses suggest that the formation of metallic Ru on the support plays a key role in the catalytic activity. Ru supported on alumina, after a reduction treatment, achieves good activity (62% conversion) and a complete selectivity in a very sustainable process (without a solvent and with air as oxidant), as indicated by the very low E-factor value. The formulation is very stable and maintains high activity after recycling.
In vitro T2 relaxivities of the Gd-based contrast agents (GBCAs) in human blood at 1.5 and 3 T (2018)

Background The availability of data in the medical literature for the T 2 relaxivities of the Gd-based contrast agents (GBCAs) is limited. A comprehensive comparison between the agents available commercially (other than in Europe) is lacking, with no data available that most closely reflect the clinic, which is in human whole blood at body temperature. Purpose To complement the existing literature by determining T 2 relaxivity data for eight GBCAs in vitro. Material and Methods The relaxivities of eight GBCAs diluted in human whole blood at 1.5 and 3 T were determined at 37 ± 0.5 °C. Gd was in the range of 0–4 mM. Multi-echo sequences with variable echo times were acquired using a phantom containing a dilution series with each agent, and SigmaPlot 12.0 was used to calculate the R 2 relaxation rate and finally r 2 . Statistical comparisons between agents and field strengths were conducted. Results The relationship between R 2 vs. Gd was observed to be linear at 1.5 and 3 T, with a mild increase in r 2 from 1.5 to 3 T for all GBCAs. T 2 relaxivity data were compared with prior results. The GBCAs are closely clustered into two groups, with higher r 2 noted for the two lipophilic (those with partial hepatobiliary excretion) compounds. Conclusion The r 2 values at 1.5 and 3 T, determined for the eight GBCAs still clinically available (other than in Europe), provide a definitive baseline for future evaluations, including theoretical calculations of signal intensity and their clinical impact on T2-weighted scans.
Dynamical principles in biological processes: A model of charge migration in proteins and DNA (2000)

The generalized master equations (GMEs) that contain multiple time scales have been derived quantum mechanically. The GME method has then been applied to a model of charge migration in proteins that invokes the hole hopping between local amino acid sites driven by the torsional motions of the floppy backbones. This model is then applied to analyze the experimental results for sequence-dependent long-range hole transport in DNA reported by Meggers et al. [Meggers, E., Michel-Beyerle, M. E., & Giese, B. (1998) J. Am. Chem. Soc. 120, 12950-12955]. The model has also been applied to analyze the experimental results of femtosecond dynamics of DNA-mediated electron transfer reported by Zewail and co-workers [Wan, C., Fiebig, T., Kelley, S. O., Treadway, C. R., Barton, J. K. & Zewail, A. H. (1999) Proc. Natl. Acad. Sci. USA 96, 6014-6019]. The initial events in the dynamics of protein folding have begun to attract attention. The GME obtained in this paper will be applicable to this problem.
Proceedings of the 2006 ACM SIGGRAPH symposium on Videogames (2006)

We pulled it off. Despite a late start, funding anxieties, and a computer that just wouldn't play 720p Quicktime, the first annual Sandbox Symposium was held July 30 & 31 2006 at the Boston Marriot Copley Plaza hotel. The event brought together more than 200 participants, 20 papers, 14 posters and 5 panel discussions for two days of talks, and discussions. Saturday night was the Carnival where Birds-of-a-Feather participants tried to hear each other over the sounds of Guitar Hero II, Halo II, and the rest of the tournament. The joint was jumpin', especially when the cash bar Karaoke session got going. The second day closed with the hot games session, previewing 8 unreleased titles from large and small publishers.We tried to keep the program light with a mixture of papers and panels, fun and games. A pitch was played during the two days to provide an experiential component to the affair. We chose 20 papers from over 90 submissions (we included a 21st in the publication to represent one of the panels). We evaluated the papers from two perspectives: from outside looking in, we looked for insight into cutting edge technology and gameplay; and from inside looking out, we asked about the role of videogames in society and their value as cultural artifacts. We accepted papers and posters on a broad range of subjects including education, animation, writing, procedural art, computer graphics, modeling, game physics, and artificial intelligence. We liked subjects that were timely and controversial. One examined the politics of military funding for videogames. A lively (and often very funny) panel explored the (often grim) realities of game industry employment. The best paper award was given to Yotam Gingold of New York University for From Rock, Paper, Scissors to Street Fighter II: Proof by Construction. This reduced the gameplay of competitive fighting to variants of the children's game Rock, Paper, Scissors.Even our keynotes were chosen to present contrasts. Greg Costikyan, CEO of Manifesto Games, spoke on designing for intensity. Greg's thesis was that all of the advanced technology, fantastic artwork, and beautiful graphics in the world can't make a game interesting if it doesn't have good gameplay. Good gameplay comes from process intensity, game dynamics and procedural content that depend in part on the player. Our second keynote speaker, Ian Shaw, Chief Technology Officer for Electronic Arts-UK, described the realities of big budget, high technology, high end game production at a leading development studio. His talk gave us a birds eye view of the industry as it is presently composed and explained the practices and constraints that they work under.We hope that you enjoy the papers and panel presentations in this proceedings, and that you attend next years Sandbox Symposium which will be co-located with SIGGRAPH in San Diego!
Influence of Angiotensin II on Expression of Toll-like Receptor 2 and Maturation of Dendritic Cells in Chronic Cyclosporine Nephropathy (2007)

AngII plays a pivotal role in activating the innate immune response in CsA-induced renal injury.
The role of prostaglandin E<sub>2</sub> in environmental factors of psychiatric disorders (2020)

We investigated the possibility of prostaglandin E2 (PGE2) as one of common molecules associated with vulnerability to neurodevelopmental disruptions induced by environmental factors. PGE2 levels in whole brain were significantly increased after exposure to viral infection [injection of polyinosinic-polycytidylic acid (polyI:C)], hypoxia (exposure to CO2), and neglect (separation from the dams) in postnatal day (PD) 2, compared to those after non-exposure. The mice administered polyI:C during PD 2-6 exhibited the impairment of sociality, object recognition memory, and pre-pulse inhibition (PPI) in adult at PD 70, and further, significant decreased spine density of the mPFC in adult mice. Exposure to CO2 at PD 2 and separation from dams during PD 2-21 exhibited the impairment of PPI and decrease of spine density in adult mice. These behavioral impairments induced by administration of polyI:C were recovered by an inhibition of PGE2-EP1 (PGE2 receptor subtype) and of cyclooxygenase (COX). Our findings suggest that PGE2 is one of potential common molecules associated with vulnerability to neurodevelopmental disruptions induced by environmental factors, and PGE2 plays a crucial role in the development of behavioral and neuronal impairments, which are associated with activation of PGE2-EP1.
ChemInform Abstract: Flow Microreactor Synthesis of Tricyclic Sulfonamides via N‐Tosylaziridinyllithiums. (2012)

Abstract A flow microreactor system is set up to deprotonate N‐tosyl aziridines with PhLi immediately followed by quenching with different electrophiles.
Brain morphology in first-episode schizophrenia (1995)

These findings indicate that structural brain abnormalities are present very early in schizophrenia and may not be due to factors such as treatment or chronicity of illness. Rather, since the abnormalities are present near the onset of the illness, a neurodevelopmental mechanism may be suggested.
AB097. 226. The role of prophylactic negative pressure dressing after laparotomy: results from a randomised controlled trial (2018)

Background: Laparotomies are associated with high rates of morbidity, of which surgical site infections (SSI) are highly prevalent. There is sparse evidence to support routine application of prophylactic negative pressure dressings to closed laparotomy wounds. A randomised controlled trial (RCT) was undertaken to assess whether prophylactic negative pressure dressings reduce the incidence of postoperative SSI after laparotomy.
Optimum electronic dispersion compensation strategies for nonlinear transmission (2006)

Digital signal processing combined with either pre-distortion at the transmitter or coherent detection at the receiver can eliminate penalties due to fibre dispersion. The nonlinearity of transmission fibre results in an optimal balance of pre-distortion and receiver equalisation.
Cloud Transmission: System simulation and performance analysis (2013)

The Cloud Transmission (Cloud Txn) is a new paradigm of broadcasting or point-to-multipoint transmission system, designed for efficient and flexible use of the spectrum, robustness against noise, multipath and co-channel interference, and capability to provide fixed or mobile reception while using low transmission power. Besides system capability, the system should meet many other challenging issues. The main purpose of this work is to demonstrate that this proposed new system is feasible and it meets today and future needs of the broadcasting industry.
Metformin increases fasting plasma peptide tyrosine tyrosine (PYY) in women with polycystic ovarian syndrome (PCOS) (2008)

Acute and chronic oral metformin administration increase fasting PYY levels and may contribute to metformin's weight loss effect. Further studies are now required to clarify whether changes in circulating PYY levels in response to metformin treatment can be used to predict which patients will subsequently lose weight long-term and gain cycle restoration.
Ombitasvir/paritaprevir/r, dasabuvir and ribavirin for cirrhotic HCV patients with thrombocytopaenia and hypoalbuminaemia (2020)

Abstract Background & Aims Thrombocytopaenia and hypoalbuminaemia are surrogate markers for portal hypertension and hepatic synthetic dysfunction respectively. Patients infected with hepatitis C virus ( HCV ) with these surrogates have reduced likelihood of sustained virologic response and increased risk for hepatic decompensation or death when treated with peginterferon/ribavirin plus either telaprevir or boceprevir. Methods We conducted a post‐hoc analysis of the TURQUOISE ‐ II clinical trial in patients with cirrhosis to examine the impact of these surrogates on efficacy and safety of ombitasvir/paritaprevir/ritonavir and dasabuvir with ribavirin. Results Of 380 genotype 1‐infected patients in TURQUOISE ‐ II , 104 had either a platelet count <100 × 10 9 /L or albumin <3.5 g/dl. Sustained virologic response rates were 89 and 97% in patients with thrombocytopaenia, and 84 and 89% in patients with hypoalbuminaemia after 12 and 24 weeks of ombitasvir/paritaprevir/ritonavir and dasabuvir with ribavirin respectively. These rates were similar to those observed in the overall study population (92 and 97% for 12 and 24 weeks). HCV genotype 1a‐infected patients with thrombocytopaenia or hypoalbuminaemia had higher response rates when treated for 24 weeks, whereas only 1 of 35 genotype 1b patients did not achieve a sustained virologic response. Adverse event rates and discontinuations because of adverse events were low. Conclusions The findings of these analyses support the use of ombitasvir/paritaprevir/ritonavir and dasabuvir with ribavirin in these subpopulations with cirrhosis. Genotype 1a‐infected patients with indicators of portal hypertension may benefit from a 24‐week treatment duration.
Submicron optical lithography using an inorganic resist/polymer bilevel scheme (1980)

The Ag2Se/GeSe inorganic photoresist system has been used to produce submicron features by optical lithography. A practical process incorporating this material is the inorganic resist/polymer bilevel scheme. The successful printing of 0.5 μm lines and spaces is explained by the existence of an ’’edge sharpening’’ effect which accompanies the photo-doping process. Conventionally accepted limitations of photolithography are circumvented by the Ag2Se/GeSe resist, whose properties also include high contrast, resistance to O2 plasma, and high absorbance of UV light.
USE OF BABY WIPES IN THE DIAPER AREA IN NEWBORNS: A PROSPECTIVE, RANDOMIZED CLINICAL STUDY ON SKIN BARRIER (2008)

Objective To investigate the effect of baby wipes compared to cotton wool with clear water on skin barrier in healthy, full-term newborns. Methods In a monocenter, prospective, randomized clinical study 40 healthy, full-term neonates (20 boys and 20 girls) aged ⩽48 hours were recruited and randomly assigned to group 1 (n = 20, use of baby wipes: wet wipes with stripes of emollients) and to group 2 (n = 20, use of cotton wool cloth, moistened with clear water during diaper changes). During the observation period both groups had obtained a standard skin care regime. Transepidermal water loss (TEWL), stratum corneum hydration (SCH) and skin pH were measured on day 2, 14 and 28 of life on the abdomen, upper leg and buttock. The D-Squame method was performed at day 2, 14 and 28 on the upper leg and buttock. Microbiological skin colonisation in the area of the umbilical and gluteal region was performed at day 2 and 28. Results Group 1 showed a significantly lower TEWL on the buttocks (9.6 g/m 2 /h) compared to group 2 (11.15 g/m 2 /h) at day 28. No differences in SCH, skin surface pH, epidermal desquamation and frequency of diaper dermatitis were found comparing both groups. Conclusions The use of these particular baby wipes with high emollient content on the diaper area seems to stabilize the skin barrier better than using a cotton wool cloth with water. Both cleansing procedures do not harm the natural maturation of skin barrier within the first four weeks of extra-uterine life.
Impaired chromaffin cell excitability and exocytosis in autistic Timothy syndrome TS2‐neo mouse rescued by L‐type calcium channel blockers (2019)

L-type voltage-gated calcium (Cav1) channels have a key role in long-term synaptic plasticity, sensory transduction, muscle contraction and hormone release. A point mutation in the gene encoding Cav1.2 (CACNA1C) causes Tymothy syndrome (TS), a multisystem disorder featuring cardiac arrhythmias, autism spectrum disorder (ASD) and adrenal gland dysfunction. In the more severe type-2 form (TS2), the missense mutation G406R is on exon 8 coding for the IS6-helix of the Cav1.2 channel. The mutation causes reduced inactivation and induces autism. How this occurs and how Cav1.2 gating-changes alter cell excitability, neuronal firing and hormone release on a molecular basis is still largely unknown. Here, using the TS2-neo mouse model of TS we show that the G406R mutation altered excitability and reduced secretory activity in adrenal chromaffin cells (CCs). Specifically, the TS2 mutation reduced the rate of voltage-dependent inactivation and shifted leftward the activation and steady-state inactivation of L-type channels. This markedly increased the resting 'window' Ca<sup>2+</sup> current that caused an increased percentage of CCs undergoing abnormal action potential (AP) burst firing, cell swelling, reduced mitochondrial metabolism and decreased catecholamine release. The increased 'window' Ca<sup>2+</sup> current caused also decreased Na<sub>V</sub> channel density and increased steady-state inactivation, which contributed to the increased abnormal burst firing. Overnight incubation with the L-type channel blocker nifedipine rescued the normal AP firing of CCs, the density of functioning Na<sub>V</sub> channels and their steady-state inactivation. We provide evidence that CC malfunction derives from the altered Cav1.2 channel gating and that dihydropyridines are potential therapeutics for ASD.