gebhart/patrepeval huggingface dataset:
Endothelial Cells Contain a Glycine-Gated Chloride Channel (2001)

Glycine inhibited growth of B16 melanoma tumors in vivo most likely because of the inhibition of angiogenesis. Here, the hypothesis that the anticancer effect of glycine in vivo is due to expression of a glycine-gated Cl- channel in endothelial cells was tested. First, the effects of glycine on vascular endothelial growth factor-induced increases in intracellular Ca2+ concentration in a bovine endothelial (CPA) cell line were studied. Vascular endothelial growth factor (1 ng/ml) increased intracellular Ca2+ concentration, with peak values reaching 141 +/- 11 nM. Glycine blunted this increase dose dependently. Furthermore, the inhibitory effects of glycine were prevented by 1 microM strychnine, a glycine receptor antagonist, or when cells were incubated in Cl(-)-free buffer. Moreover, glycine increased influx of 36Cl into CPA cells approximately 10-fold; this reaction was also strychnine sensitive. Furthermore, mRNA similar to the beta-subunit of the glycine-gated Cl- channel from spinal cord was identified in endothelial cells by reverse transcription-polymerase chain reaction. In addition, Western analysis using antibody for the glycine receptor demonstrated expression of the beta-subunit of the glycine receptor. Importantly, glycine diminished serum-stimulated proliferation and migration of endothelial cells. Collectively, these data indicate that the inhibitory effect of glycine on growth and migration of endothelial cells is due to activation of a glycine-gated Cl- channel. This hyperpolarizes the cell membrane and blocks influx of Ca2+, thereby minimizing growth factor-mediated signaling.
A Recurrent Loss-of-Function Alanyl-tRNA Synthetase (AARS) Mutation in Patients with Charcot-Marie-Tooth Disease Type 2N (CMT2N) (2014)

The original article to which this Erratum refers was published in Human Mutation 33:244–253, 2012 (DOI 10.1002/humu.21635). The table in this article entitled, “Table 3: Human AARS Variants Modeled in the Yeast Ortholog ALA1”, contains a typographical error. For the human AARS mutation R329H, the corresponding yeast ALA1 mutation should read “R333H”, not “R329H”. The authors regret the error and are grateful to Laurie Griffin from the Antonellis laboratory for pointing it out. Below is the corrected table:
Targeting VEGF in eye neovascularization: What's new? (2015)

Roughly ten years ago the FDA approved most of the presently used anti-VEGF drugs for the treatment of neovascular AMD and other eye pathologies characterized by ocular neoangiogenesis. However, the recent findings on the physiologic activities of VEGF isoforms impose to reconsider the inhibitory effects of pan-VEGF antagonists and the concept that to face pathological alterations at ocular level is possible only through the full block of all VEGF isoforms. In fact, although pan-VEGF agents rapidly and effectively contrast ocular neovascularization, vascular leakage, and other pathological changes, in the long-term the inhibition of all VEGF isoforms likely may result in the loss of the physiologic effects exerted by VEGF121 and the anti-angiogenic VEGF165b. Notably, selective inhibitors of VEGF165a, such as pegaptanib, spare these targets. Moreover, preclinical and clinical evidence suggests that also systemic side effects, secondary to intraocular treatment with non-selective anti-VEGF drugs, may be reinterpreted in light of these recent findings, which may be useful to clinicians for the choice of the most appropriate anti-VEGF agent. Another aspect that should be considered is the involvement of VEGF-independent pathways in ocular neovascularization, therefore a combined therapy can represent a more effective pharmacological approach that might help also to counteract tachyphylaxis, an important issue in anti-VEGF treatment. This complex picture and the recent findings on current anti-VEGF drugs should be therefore taken into account to guide the development of novel agents targeting VEGF and/or other key factors involved in the pathogenesis of neovascular ocular diseases along the signaling pathways stimulated by the various isoforms. Accordingly, this review also reports on novel pharmacological molecules targeting VEGF at ocular level and currently under development, with a special attention to oligonucleotide-based interventions.
JAK2V617F mutational status and allele burden have little influence on clinical phenotype and prognosis in patients with post-polycythemia vera and post-essential thrombocythemia myelofibrosis (2008)

The inclusion of high-dose therapy/autologous stem cell transplantation (HDT/ASCT) in the initial treatment plan for patients with unfavorable Hodgkin's lymphoma
What is multithreading and multi-core? (2007)

Is multithreading better than multi-core? Is multi-core better than multithreading? The fact is that the best vehicle for a given application might have one, the other or both. Or neither. They are independent (but complementary) design decisions. As multithreaded processors and multi-core chips become the norm, architects and designers of digital systems need to understand their respective attributes, advantages and disadvantages. Both multithreading and multi-core approaches exploit the concurrency in a computational workload. The cost, in silicon, energy and complexity, of making a CPU run a single instruction stream ever faster goes up nonlinearly and eventually hits a wall imposed by the physical limitations of circuit technology. That wall keeps moving out a little farther every year, but cost- and power-sensitive designs are constrained to follow the bleeding edge from a safe distance. Fortunately, virtually all computer applications have some degree of concurrency: At least some of the time, two or more independent tasks need to be performed simultaneously. Taking advantage of concurrency to improve computing performance and efficiency isn't always trivial, but it's certainly easier than violating the laws of physics.
Conserved retinoblastoma protein-binding motif in human cytomegalovirus UL97 kinase minimally impacts viral replication but affects susceptibility to maribavir (2009)

The UL97 kinase has been shown to phosphorylate and inactivate the retinoblastoma protein (Rb) and has three consensus Rb-binding motifs that might contribute to this activity. Recombinant viruses containing mutations in the Rb-binding motifs generally replicated well in human foreskin fibroblasts with only a slight delay in replication kinetics. Their susceptibility to the specific UL97 kinase inhibitor, maribavir, was also examined. Mutation of the amino terminal motif, which is involved in the inactivation of Rb, also renders the virus hypersensitive to the drug and suggests that the motif may play a role in its mechanism of action.
Wireless Sensor Networks for Developmental and Flight Instrumentation (2011)

Wireless sensor networks (WSN) based on the IEEE 802.15.4 Personal Area Network and ZigBee Pro 2007 standards are finding increasing use in home automation and smart energy markets providing a framework for interoperable software. The Wireless Connections in Space Project, funded by the NASA Engineering and Safety Center, is developing technology, metrics and requirements for next-generation spacecraft avionics incorporating wireless data transport. The team from Stennis Space Center and Mobitrum Corporation, working under a NASA SBIR grant, has developed techniques for embedding plug-and-play software into ZigBee WSN prototypes implementing the IEEE 1451 Transducer Electronic Datasheet (TEDS) standard. The TEDS provides meta-information regarding sensors such as serial number, calibration curve and operational status. Incorporation of TEDS into wireless sensors leads directly to building application level software that can recognize sensors at run-time, dynamically instantiating sensors as they are added or removed. The Ames Research Center team has been experimenting with this technology building demonstration prototypes for on-board health monitoring. Innovations in technology, software and process can lead to dramatic improvements for managing sensor systems applied to Developmental and Flight Instrumentation (DFI) aboard aerospace vehicles. A brief overview of the plug-and-play ZigBee WSN technology is presented along with specific targets for application within the aerospace DFI market. The software architecture for the sensor nodes incorporating the TEDS information is described along with the functions of the Network Capable Gateway processor which bridges 802.15.4 PAN to the TCP/IP network. Client application software connects to the Gateway and is used to display TEDS information and real-time sensor data values updated every few seconds, incorporating error detection and logging to help measure performance and reliability in relevant target environments. Test results from our prototype WSN running the Mobitrum software system are summarized and the implications to the scalability and reliability for DFI applications are discussed. Our demonstration system, incorporating sensors for life support system and structural health monitoring is described along with test results obtained by running the demonstration prototype in relevant environments such as the Wireless Habitat Testbed at Johnson Space Center in Houston. An operations concept for improved sensor process flow from design to flight test is outlined specific to the areas of Environmental Control and Life Support System performance characterization and structural health monitoring of human-rated spacecraft. This operations concept will be used to highlight the areas where WSN technology, particularly plug-and-play software based on IEEE 1451, can improve the current process, resulting in significant reductions in the technical effort, overall cost and schedule for providing DFI capability for future spacecraft. RELEASED -
Glycosyl Transfer to Nitrogen via Cycloaddition (1999)

[formula: see text] This letter describes the reduction to practice of a novel concept for functionalization of the anomeric carbon of carbohydrates with a nitrogen substituent. Thus, bisheterodienes with a thiono sulfur terminus and a sulfonylimine terminus are shown to undergo cycloaddition smoothly and stereoselectively to three different glycals.
Comprehensive Analysis of the Prognostic Value and Immune Infiltrates of the Three-m5C Signature in Colon Carcinoma (2021)

In conclusion, our study illustrates that the three-m5C signature may be involved in the regulation of colon cancer immune microenvironment in synergy with the MAPK signaling pathway. Therefore, further studying the three-m5C signature regulatory mechanisms might provide promising targets for improving the responsiveness of colon cancer to immunotherapy.
Studies in Dormancy of Sycamore (1959)

1. An investigation was made into effect of daylength conditions of the inhibition content of first-year seedlings of sycamore ( Acer pseudoplatanus ). 2. The shoot apical regions and mature leaves were extracted with 80 per cent. Aqueous methanol, fractionated by paper chromatography in isopropanol/ammonia and assayed by the wheat-coleptile growth test. 3. A growth inhibitor was present in all extracts at R f 0.7. Higher levels of inhibitor were present in both apices and mature leaves of plants transferred to short-day conditions than of those maintained under long-days throughout. 4. These difference in inhibitor level can be detected after 2–5 days of short-day treatment, Preceding any marked effect of daylength on growth. 5. Evidence is adduced in support of the hypothesis that the inhibitors is produced in the leaves during darkness and is transported to the apex during the photoperiod.
The role of seminal plasma for improved outcomes during in vitro fertilization treatment: review of the literature and meta-analysis (2014)

There are significantly improved outcomes when women are exposed to seminal plasma around the time of ovum pick-up or embryo transfer, with statistical significance for clinical pregnancy but not for ongoing pregnancy/live birth rates being achieved. This meta-analysis is limited by the small number of studies of variable methodology. Further research is required to determine the effect on live birth rate; however, this meta-analysis indicates a significantly improved clinical pregnancy rate and a potential method for improving IVF outcomes.
ROTATIONAL ANALYSIS OF THE VIBRATIONAL GROUND STATE OF ACETONE, $CH_{3}COCH_{3}$ (1998)

An effective rotational $Hamiltonian^{a}$ was used to analyze rotational transitions in the vibrational ground state of acetone. Microwave and mm-wave measurements from the $literature^{b}$ were combined with new measurements between 260 and 350 GHz and with new FT microwave frequencies in a global fit of all four torsional substates. Over 500 frequencies between 8 and 350 GHz were fit for transitions involving energy levels with J up to 34 and $K_{a}$ up to 10. In one (preliminary) fit, 31 spectroscopic parameters were used to fit 555 frequencies to a dimensionless standard deviation of 1.25. The parameters determined in the least-squares fit were: $\\rho = 0.0621754(64), \\beta = 25.8160(73)$ deg., parameters equivalent to the rotational, quartic and sextic distortion constants, the internal energy tunneling parameters $\\epsilon_{01} = -763.436(83) MHz, \\epsilon_{1-1} = 0.1057(62) MHz, \\epsilon_{11} = 0.991(34) MHz, \\epsilon_{02} = 0.585(14) MHz$ and ten tunneling constants related to the rotational and distortion constants. This particular fit is not quite satisfactory because a number of transitions, including low $K_{**}$ R-transitions, had to be excluded from the fit.
A geometrical approach for inverting display color‐characterization models (2008)

Abstract— Some display color‐characterization models are not easily inverted. This work proposes ways to build geometrical inverse models given any forward color‐characterization model. The main contribution is to propose and analyze several methods to optimize the 3‐D geometrical structure of an inverse color‐characterization model directly based on the forward model. Both the amount of data and their distribution in color space is especially focused on. Several optimization criteria, related either to an evaluation data set or to the geometrical structure itself, are considered. A practical case with several display devices, combining the different methods proposed in the article, are considered and analyzed.
No viscous fingers in heterogeneous porous media (1994)

We have carried out computer simulation of miscible displacements in porous media in which the permeabilities vary spatially according to a fractional Brownian motion. This distribution induces long-range correlations and bas been found to describe the permeabilities of heterogeneous rocks. Our simulation shows that conventional viscous fingers, which are the result of the contrant M between the viscosities of the displacing and displaced fluids, and are usually found in laboratory experiments, do not exist. Displacement patterns and efficiency are controlled by the heterogeneities, and the viscosity contrast M, varied here between 1 and α, han essentially no effect.
Microfilaments in amorphous chalcogenide memory devices (1975)

Observations of very low values of the holding current of amorphous chalcogenide memory devices, which have nearly complete crystalline filaments, are attributed to microfilaments which connect neighbouring crystallites. The effect of the trailing edge of the set pulse when switching memory devices is described, and the observations are attributed to the occasional occurrence of microfilaments which do not crystallize unless cooled slowly. Microfilaments may also explain the effect of polarity when additional short set pulses are applied to a fully set switch. Distinctive changes in resistivity occur, which may be due to electromigration.
A New and Versatile Approach to the Preparation of H-Phosphonate Analogues for Adp and Atp (1990)

Abstract Phosphonylation of nucleotides with a new reagent, diphosphonate, was found to be very effective for the preparation of P-O-P bridged H-phosphonate analogues of ADP and ATP.
Synthesis and photoluminescence of linear and hyperbranched polyethers containing phenylquinoxaline units and flexible aliphatic spacers (2004)

Abstract Ultrahigh‐molecular‐weight linear polyethers were prepared through a reaction between the phenylquinoxaline monomers 2,3‐bis(4‐hydroxyphenyl)‐6‐fluoroquinoxaline and 2,3‐bis(4‐hydroxyphenyl)‐6‐(α,α,α‐trifluoromethyl)quinoxaline and 1,12‐dibromododecane. A new hyperbranched polyether containing a phenylquinoxaline moiety was also prepared from a new self‐polymerizable AB 2 monomer, 2,3‐bis(6‐bromohexyloxyphenyl)‐6‐(4‐hydroxyphenyloxy)quinoxaline. All the polyethers were amorphous and soluble in polar aprotic solvents. Their solution‐cast thin films were light yellow, ductile, and optically transparent. The polymers were thermally stable up to 350 °C and had glass‐transition temperatures in the range of 25–83 °C, which depended on the architecture and monomer structure. The monomers and polymers displayed fluorescence maxima in the blue‐light region in the range of 431–449 nm with relatively narrow peak widths; this indicated that they had pure and intense fluorescence. © 2004 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 42: 3587–3603, 2004
Barrier properties of PLA and PHB in reation with the formulation and the crystallinity (2009)

absent
Misdiagnosed malignancy in transplanted organs (1993)

Abstract. The case reports of three patients who received cancer-bearing organs at this institution are presented. A fourth recipient, who was to be transplanted with a cancerous kidney, was spared this disastrous complication. The relevant data regarding the donors is also alluded to, with special reference to the type and site of the primary malignancy. Following these case reports, the implications of these issues, their possible prevention, and further management are discussed.
AIDS Clinical Trials Group 5197: A Placebo‐Controlled Trial of Immunization of HIV‐1–Infected Persons with a Replication‐Deficient Adenovirus Type 5 Vaccine Expressing the HIV‐1 Core Protein (2010)

The vaccine was generally safe and well tolerated. Despite a trend favoring viral suppression among vaccine recipients, differences in HIV-1 RNA levels did not meet the prespecified level of significance. Induction of HIV-1 gag-specific CD4 cells correlated with control of viral replication in vivo. Future immunogenicity studies should require a substantially higher immunogenicity threshold before an ATI is contemplated.
RS-88 Pad Abort Demonstrator Thrust Chamber Assembly Testing at NASA Marshall Space Flight Center (1990)

This paper documents the effort conducted to collect hot-tire dynamic and acoustics environments data during 50,000-lb thrust lox-ethanol hot-fire rocket testing at NASA Marshall Space Flight Center (MSFC) in November-December 2003. This test program was conducted during development testing of the Boeing Rocketdyne RS-88 development engine thrust chamber assembly (TCA) in support of the Orbital Space Plane (OSP) Crew Escape System Propulsion (CESP) Program Pad Abort Demonstrator (PAD). In addition to numerous internal TCA and nozzle measurements, induced acoustics environments data were also collected. Provided here is an overview of test parameters, a discussion of the measurements, test facility systems and test operations, and a quality assessment of the data collected during this test program.
A liquid VI scintillator cell for fast-gated neutron imaging (2018)

The design of a new fast-gated neutron imaging system for the National Ignition Facility with much stricter timing constraints than a previous system has prompted the search for a fast scintillator material that can be used in imaging. A novel imaging cell based on Liquid VI has recently been developed with Eljen Technology and characterized at the Special Technologies Laboratory and the Los Alamos Neutron Science Center. The results show superior timing characteristics and spatial resolution, and sufficient light production for the new system compared to fast plastic scintillators previously used in neutron imaging. While the primary application is in inertial confinement fusion diagnostics, the imaging cell can be used in any fast-gated imaging application where timing characteristics and spatial resolution are of concern.
<title>Nanocrystalline diamond films: laser assisted fabrication, optical and electronic properties</title> (2005)

In this paper, experimental data are presented on the synthesis and properties of nanocrystalline diamond (NCD) films grown by a dc plasma CVD technique from various gas mixtures (CH<sub>4</sub>-H<sub>2</sub>, CH<sub>4</sub>-H<sub>2</sub>-Ar, CH<sub>4</sub>-Ar, CH<sub>4</sub>-H<sub>2</sub>-N<sub>2</sub>, CH<sub>4</sub>-Ar- N<sub>2</sub>). The interrelation between the CVD conditions, the film microstructure and film properties is established using Raman spectroscopy, XRD, XPS, AES, SEM, TEM, AFM/STM, spectroscopic ellipsometry and optical transmission spectroscopy techniques. Experimental methods for laser assisted fabrication of ultrathin and highly smooth NCD films are described. Effects of the deposition parameters (substrate temperature, CH<sub>4</sub> content, addition of Ar gas to CH/H<sub>2</sub> gas mixtures) on the grain size, surface roughness and optical properties of NCD films are discussed. Results of nitrogen doping of nanocrystalline diamond films are presented and discussed.
Azafullerenes Encapsulated within Single-Walled Carbon Nanotubes (2008)

Methods of insertion of azafullerenes in single-walled carbon nanotubes (SWNTs) at different temperatures were investigated, while the effects of the conditions applied on the structure of azafullerene-based peapods, namely, C59N@SWNTs, were explored. Morphological characteristics of C59N@SWNTs were assessed and evaluated by means of high-resolution transmission electron microscopy (HR-TEM). Pathways and chemical reactions that occur upon encapsulation of C59N within SWNTs were evaluated. Monomeric azafullerenyl radical C59N. as inserted into SWNTs at high temperature, from purified (C59N)2 in the gas phase, can undergo a variety of different transformations forming dimers, oligomers or existing in its monomeric form inside SWNTs due to the stabilization effect by nanotube side walls. However, under milder conditions, that is, at lower temperature, bisazafullerene (C59N)2 can be inserted into SWNTs in its pristine dimeric form.
TDP1 suppresses mis-joining of radiomimetic DNA double-strand breaks and cooperates with Artemis to promote optimal nonhomologous end joining (2018)

The Artemis nuclease and tyrosyl-DNA phosphodiesterase (TDP1) are each capable of resolving protruding 3'-phosphoglycolate (PG) termini of DNA double-strand breaks (DSBs). Consequently, both a knockout of Artemis and a knockout/knockdown of TDP1 rendered cells sensitive to the radiomimetic agent neocarzinostatin (NCS), which induces 3'-PG-terminated DSBs. Unexpectedly, however, a knockdown or knockout of TDP1 in Artemis-null cells did not confer any greater sensitivity than either deficiency alone, indicating a strict epistasis between TDP1 and Artemis. Moreover, a deficiency in Artemis, but not TDP1, resulted in a fraction of unrepaired DSBs, which were assessed as 53BP1 foci. Conversely, a deficiency in TDP1, but not Artemis, resulted in a dramatic increase in dicentric chromosomes following NCS treatment. An inhibitor of DNA-dependent protein kinase, a key regulator of the classical nonhomologous end joining (C-NHEJ) pathway sensitized cells to NCS, but eliminated the sensitizing effects of both TDP1 and Artemis deficiencies. These results suggest that TDP1 and Artemis perform different functions in the repair of terminally blocked DSBs by the C-NHEJ pathway, and that whereas an Artemis deficiency prevents end joining of some DSBs, a TDP1 deficiency tends to promote DSB mis-joining.