gebhart/patrepeval huggingface dataset:
[Lawrence] D. Clark, [William] W. Pelton, [Hiram] E. Perkins, [Dudley K.] Andross, [Oscar S.] Tuttle, [William] H. Boynton, [Joseph] Bush, [David B.] Peck, [Eben S.] Hayward, and Wm. Y. W. Ripley to John Wolcott Phelps (2010)

Topics include the commanding officers of the 1st Regiment of the Vermont Volunteer Militia requesting the 1st Regiment be allowed to stay at the Willard Hotel.
The Bisurface Total Knee Replacement: A Unique Design for Flexion (2000)

Total knee arthroplasty with the Bisurface prosthesis resulted in an excellent range of motion and a high level of satisfaction with the operation; the durability of the prosthesis is promising.
3D culture of adult mouse neural stem cells within functionalized self-assembling peptide scaffolds (2011)

Three-dimensional (3D) in vitro models of cell culture aim to fill the gap between the standard two-dimensional cell studies and the in vivo environment. Especially for neural tissue regeneration approaches where there is little regenerative capacity, these models are important for mimicking the extracellular matrix in providing support, allowing the natural flow of oxygen, nutrients, and growth factors, and possibly favoring neural cell regrowth. We have previously demonstrated that a new self-assembling nanostructured biomaterial, based on matrigel, was able to support adult neural stem cell (NSC) culture. In this study, we developed a new 3D cell culture system that takes advantage of the nano- and microfiber assembling process, under physiologic conditions, of these biomaterials. The assembled scaffold forms an intricate and biologically active matrix that displays specifically designed functional motifs: RGD (Arg-Gly-Asp), BMHP1 (bone marrow homing peptide 1), and BMHP2, for the culture of adult NSCs. These scaffolds were prepared at different concentrations, and microscopic examination of the cell-embedded scaffolds showed that NSCs are viable and they proliferate and differentiate within the nanostructured environment of the scaffold. Such a model has the potential to be tailored to develop ad hoc designed peptides for specific cell lines.
DVB-T Power Amplifiers Modelling and Compensation (2006)

Digital video broadcasting terrestrial (DVB-T) signals, used in digital terrestrial television (DTT) networks in Europe, can have a very high crest factor of around 13 dB. Consequently broadcast power amplifiers need to be as linear as possible to avoid spectral regrowth interfering with adjacent channels. The first solution is to use a class A amplifier which is of course very linear but has a poor efficiency. The second solution is to replace the class A amplifier by a class AB amplifier with a predistorter to improve its linearity. LDMOS class AB amplifiers are being more often used for this application. To simulate such a system including an amplifier, the first step is often to model the amplifier. A great number of models have been proposed but they are generally just applicable to one kind of amplifier. We will compare them to the memoryless Abuelma'atti model based on Bessel expansion series for in-phase and quadrature parts of the signal. Then a digital predistorter using look up tables of gain and phase is described and applied to the modelled amplifier
Photoanode Area Dependent Efficiency and Recombination Effects in Dye-Sensitized Solar Cells (2012)

Efficiency and electron lifetimes in dye-sensitized solar cells (DSCs) fabricated from P25 titania nanoparticles were found to be strongly dependent on the photoanode area. Tin oxide nanowires, which already exhibit higher electron lifetimes than titania nanoparticles, also showed similar behavior. Most importantly, DSCs fabricated from these materials exhibited a non-uniform photovoltage profile laterally across photoanode for areas as large as 1 cm2. The non-uniformity in photopotential distribution is enhanced with a reduction in the photoanode area indicating edge effects at smaller areas. Dye desorption from the edges of the photoanode into the liquid electrolyte results in these edge effects and can play an important role in characterizing the DSC performance. Interestingly, DSCs made using anatase nanoparticles exhibiting strong dye adsorption showed a uniform photopotential along the lateral dimension of the photoanode. Further, P25 nanoparticles based DSCs showed no spatial photopotential variation when infiltrated with a solid state electrolyte indicating that dye desorption from the nanoparticle or nanowire surfaces is a crucial factor contributing to edge effects. Mapping the photopotential distribution is a valuable tool to understand and characterize edge effects in DSCs.
MHC Class II-Restricted Epitopes Containing an Oxidoreductase Activity Prompt CD4+ T Cells with Apoptosis-Inducing Properties (2015)

Abrogating an unwanted immune response toward a specific antigen without compromising the entire immune system is a hoped-for goal in immunotherapy. Instead of manipulating dendritic cells and suppressive regulatory T cells, depleting effector T cells or blocking their co-stimulatory pathways, we describe a method to specifically inhibit the presentation of an antigen eliciting an unwanted immune reaction. Inclusion of an oxidoreductase motif within the flanking residues of MHC class II epitopes polarizes CD4(+) T cells to cytolytic cells capable of inducing apoptosis in antigen presenting cells (APCs) displaying cognate peptides through MHC class II molecules. This novel function results from an increased synapse formation between both cells. Moreover, these cells eliminate by apoptosis bystander CD4(+) T cells activated at the surface of the APC. We hypothesize that they would thereby block the recruitment of cells of alternative specificity for the same autoantigen or cells specific for another antigen associated with the pathology, providing a system by which response against multiple antigens linked with the same disease can be suppressed. These findings open the way toward a novel form of antigen-specific immunosuppression.
Friedel—Crafts Isomerization. IX.1a Aluminum Chloride Catalyzed Isomerization of the Diisopropylbenzenes (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFriedel—Crafts Isomerization. IX.1a Aluminum Chloride Catalyzed Isomerization of the DiisopropylbenzenesGeorge A. Olah, Max W. Meyer, and Nina A. OverchukCite this: J. Org. Chem. 1964, 29, 8, 2315–2316Publication Date (Print):August 1, 1964Publication History Published online1 May 2002Published inissue 1 August 1964https://doi.org/10.1021/jo01031a050RIGHTS & PERMISSIONSArticle Views121Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (205 KB) Get e-Alerts Get e-Alerts
FAST ROSSI-ALPHA MEASUREMENTS OF PLUTONIUM USING ORGANIC SCINTILLATORS (2021)

\nIn this work, Rossi-alpha measurements were simultaneously performed with a 3He-based detection system and an organic scintillator-based detection system. The assembly is 15 kg of plutonium (93 wt% 239Pu) reflected by copper and moderated by lead. The goal of Rossi-alpha measurements is to estimate the prompt neutron decay constant, alpha. Simulations estimate keff = 0:624 and α = 52:3 ± 2:5 ns for the measured assembly. The organic scintillator system estimated α = 47:4 ± 2:0 ns, having a 9.37% error (though the 1.09 standard deviation confidence intervals overlapped). The 3He system estimated α = 37 μs. The known slowing down time of the 3He system is 35-40 μs, which means the slowing down time dominates and obscures the prompt neutron decay constant. Subsequently, the organic scintillator system should be used for assemblies with alpha much less than 35 μs.
Brazilian tensile strength test of lightly cemented sand (1995)

Tensile stress – tensile strain relationships for lightly cemented sand specimens obtained by conducting Brazilian tensile strength tests have been presented. The tensile strain measurement was done by using an optical image analysis technique. In addition to the tensile strength tests, some unconfined compression tests on sand specimens with varying cement contents were also performed. Based on the results of the above tests, a nondimensional tensile stress – tensile strain relationship has been presented. Also the variation of the tensile and compressive strength and strain ratios with varying cement contents have been discussed. Key words : lightly cemented sand, optical image analysis, tensile strain, tensile strength, unconfined compression strength.
Geomorphic controls on aluminium in acid soils of the Axe Creek catchment, Victoria (1998)

This study investigates the influence of terrain, including steepness and position in slope, on soil pH, extractable aluminium (Al), and organic carbon (OC) in the Axe Creek catchment, Victoria. Both soil pH and Al were determined by use of 1 : 5 soil : 0·01 M CaCl2 extracts, with Al measured colorimetrically using a modified pyrocatechol violet method. Although all soils were acidic, the Al concentration was highest on the hilltops (&amp;gt;10 mg/kg) and lowest at base-of-slope sites (&amp;lt;1 mg/kg). The concentration of Al was generally inversely related to soil pH. However, on average, a lower Al concentration was found in the top 10 cm than in the interval from 10 to 30 cm, even though the soil pH remained relatively constant throughout the top 30 cm. The lower Al concentration in the surface layer corresponded to a substantially higher level of OC near the surface, suggesting the formation of Al-organic matter complexes.
On some possibilities and prospects of gene conservation and utilisation of pig breeds (1999)

Abstract. Nowadays, there are 47 rare pig breeds in the world the majority of which in Europe. Disappeared breeds are considered to be 139 breeds (mostly in Europe). The prevention of further losses of needs needs special measurements and methods for maintenance and conservation of genetic values. In spite of a lot of means being available, the conservation programs use the possibilities only moderately. Besides the commonly used testing results, special genetic analysis should be practised and extended widely, including blood groups, enzyme and other protein polymorphisms and the new results of genom analysis (marker genes atc). A proper – and well identified - genetic make up is of minimal precondition for preparing effective mating plans to avoid and reduce Inbreeding rate in closed populations. Besides number of traits and markers, more emphasis should be given to the distribution of the genetic markers on each chromosomes detected. If a chromosome were controlled (detected by at least 5 loci, thre would be round 200 parameters necessary as a minimum for a porper control fo the genomic background of a breed. Whilst it is very diffucult to prevent gene losses in small populations (small effective population size) for long term, reconstruction of them should be comined with cryopreservational and up-to-date DNA-screening.
Knockdown of Trop2 inhibits proliferation and migration and induces apoptosis of endometrial cancer cells via AKT/β‐catenin pathway (2020)

Endometrial cancer (EC) is the most common gynaecologic malignancy in western countries and has been reported to account for about 7% of female malignant tumours and 20% to 30% of female genital system malignant tumours. Accumulating evidence showed the expression of human trophoblast cell surface antigen 2 (Trop2) was abnormal in many cancers; however, the expression and role of Trop2 in EC are not clear. The Trop-2 protein expression was detected by western blot in EC cells. Cell proliferation, apoptosis, and migration were measured by CCK-8, flow cytometry, and Transwell assay, respectively. The epithelial mesenchymal transition (EMT) and AKT/β-catenin signalling pathway-related proteins in EC cell lines were detected by western blot assay following Trop2 gene silencing. The present study revealed that the Trop2 protein was highly expressed in EC cell lines compared with human endometrial epithelial cells. The Trop2 mRNA and protein were obviously decreased following transfection with Trop2-siRNA sequence in KLE and Ishikawa cells. Meanwhile, Trop2 gene silencing in KLE and Ishikawa cells strongly inhibited cell proliferation and migration and increased cell apoptosis. Investigation into the molecular mechanism indicated that the Trop2 gene silencing suppressed EMT and AKT/β-catenin signalling pathway activation. SIGNIFICANCE OF THE STUDY: These findings suggested that Trop2 silencing inhibited EC cell proliferation and migration and promoted cell apoptosis. The mechanism might be related to the inhibition of the AKT/β-catenin signalling pathway in EC cells. Therefore, Trop2 may be a potential therapeutic target for the treatment of EC.
Modeling Proppant Settling in Water-Fracs (2004)

Abstract Water-fracs, consisting of proppant pumped with un-gelled fluid are the type of stimulation used in many low-permeability reservoirs throughout the United States. The use of low viscosity, Newtonian, fluids allows the creation of long narrow fractures in the reservoir without the excessive height growth often seen with cross-linked fluids. Proppant transport is a central issue in all these treatments because of the low viscosity of the fracturing fluid. New models for proppant transport and settling in hydraulic fractures were developed and implemented in a 3-d hydraulic fracturing code. It is shown that a simple Stokes settling model is grossly inadequate. The proppant settling models developed in this paper account for the effects of fracture walls, changes in settling velocities and rheology caused by changes in proppant concentration, turbulence effects due to high fluid velocities and inertial effects associated with large relative velocities between the proppant and the fluid. Narrower fractures, higher proppant concentration and smaller proppant size reduce settling whereas turbulence leads to an increase in settling. Results are presented to show how the settling velocities are impacted by fluid velocity, proppant size, fluid rheology and fracture width. In most instances settling velocities differ significantly from the Stokes settling velocity. The new proppant settling model was incorporated into a 3-D hydraulic fracture simulator (UTFRAC-3D). Simulation results show that when settling is accounted for, significantly shorter propped lengths are obtained. The narrow fractures associated with water-fracs alter settling and thereby alter the proppant placement significantly. Although increasing fluid viscosity can reduce settling rates, increased height growth reduces the distance to which proppant can be placed. This clearly suggests a need to optimize fluid rheology. The improved fracture simulator can be used to better design fracture treatments (fluid rheology, injection rates, proppant concentration and size) for better proppant placement under a given set of in-situ stress conditions.
Do Aging and Dual-Tasking Impair the Capacity to Store and Retrieve Visuospatial Information Needed to Guide Perturbation-Evoked Reach-To-Grasp Reactions? (2013)

A recent study involving young adults showed that rapid perturbation-evoked reach-to-grasp balance-recovery reactions can be guided successfully with visuospatial-information (VSI) retained in memory despite: 1) a reduction in endpoint accuracy due to recall-delay (time between visual occlusion and perturbation-onset, PO) and 2) slowing of the reaction when performing a concurrent cognitive task during the recall-delay interval. The present study aimed to determine whether this capacity is compromised by effects of aging. Ten healthy older adults were tested with the previous protocol and compared with the previously-tested young adults. Reactions to recover balance by grasping a small handhold were evoked by unpredictable antero-posterior platform-translation (barriers deterred stepping reactions), while using liquid-crystal goggles to occlude vision post-PO and for varying recall-delay times (0-10 s) prior to PO (the handhold was moved unpredictably to one of four locations 2 s prior to vision-occlusion). Subjects also performed a spatial- or non-spatial-memory cognitive task during the delay-time in a subset of trials. Results showed that older adults had slower reactions than the young across all experimental conditions. Both age groups showed similar reduction in medio-lateral end-point accuracy when recall-delay was longest (10 s), but differed in the effect of recall delay on vertical hand elevation. For both age groups, engaging in either the non-spatial or spatial-memory task had similar (slowing) effects on the arm reactions; however, the older adults also showed a dual-task interference effect (poorer cognitive-task performance) that was specific to the spatial-memory task. This provides new evidence that spatial working memory plays a role in the control of perturbation-evoked balance-recovery reactions. The delays in completing the reaction that occurred when performing either cognitive task suggest that such dual-task situations in daily life could increase risk of falling in seniors, particularly when combined with the general age-related slowing that was observed across all experimental conditions.
Noise benefits in motor imagery classification using ensemble support vector machine (2014)

This paper explores how noise can improve classification accuracy of motor imagery classification using an ensemble support vector machine (ESVM) classifier. We add white Gaussian noise to the EEG signals and use them with the original signal data set for the ESVM training process. The ESVM classifier uses coefficients of the discrete wavelet transform (DWT) and coefficients of the autoregressive (AR) model as features for classification. Experimental results show that training ESVM with concatenated original data set and noise-added data sets can improve the classification accuracy. The classification system attains maximum accuracy when noise intensity is not zero and thus the system shows the stochastic resonance effect.
ChemInform Abstract: The Metal Centre Dependence of Inversion at Coordinated Sulphur. (1983)

Abstract Die Dithiahexan‐Komplexe (I)′‐(VII) werden mittels 1 H‐NMR‐Spektren bei variabler Temp untersucht.
Hazard Assessment of Ackee Fruit (Blighia sapida) (1998)

Ackee toxicity is associated with consumption of the fruit of the tree Blighia sapida. The problem is endemic in Jamaica, and a number of cases have been reported in the U.S. among Jamaican immigrants. Illness is associated with the method of preparation of the fruit and its ripeness. Malnourished individuals and children appear to be the most susceptible. Levels of the toxic compound, hypoglycin, which are found in the arils and seeds of the fruit, significantly decrease in the arils with ripeness (from 1000 ppm to <0.1 ppm). Symptoms of ackee poisoning in humans occur 6 to 48 hours after ingestion and include vomiting, muscular and mental exhaustion, hypoglycemia, coma and death. Intravenous glucose relieves the hypoglycemia. The most likely mechanism of action occurs through the incorporation of hypoglycin into fatty acid metabolic pathways. Hypoglycin or its primary metabolite methylenecyclopropyl-acetyl-CoA inhibits the oxidation of fatty acids and leucine and the activity of acyl-CoA dehydrogenases. The dose required to elicit acute responses is not known with any precision, nor is it possible to eliminate the likelihood of adverse effects with long-term ingestion of the toxin. Ingestion of unripe aril or pod and seeds represents a significant health hazard; this hazard diminishes considerably with the consumption of properly processed or prepared ripe fruit.
BENEFICIAL EFFECTS OF EXOGENOUS CROSSLINKING AGENTS ON SELF-ASSEMBLED TISSUE ENGINEERED CARTILAGE CONSTRUCT BIOMECHANICAL PROPERTIES (2010)

To our knowledge, this is the first study to examine the use of exogenous crosslinking agents on any tissue formed using a scaffoldless tissue engineering approach. In particular, this study demonstrates that a one-time treatment with crosslinking agents can be employed effectively to enhance the biomechanical properties of tissue engineered articular cartilage. The results are exciting, as they demonstrate the feasibility of using exogenous crosslinking agents to enhance the biomechanical properties without the need for increased glycosaminoglycan (GAG) and collagen content.
Fetal exomphalos at 11 to 14 weeks of gestation. (1995)

In an ultrasonographic screening study at 11 to 14 weeks' gestation involving 9885 singleton pregnancies, the prevalence of exomphalos was 0.11% (11 cases) and the prevalence of trisomy 18 or 13 was 0.35% (35 cases). The mean maternal age of the screened population was 35 years (range, 15 to 47 years) and a significant association was found between maternal age and both the prevalence of trisomies and the prevalence of exomphalos. Because the frequency of exomphalos in fetuses with trisomy 18 or 13 was 17% and in those with no evidence of these trisomies it was 0.05%, the risk for trisomies in fetuses with exomphalos is 340 times higher than in those without exomphalos.
Blind signal separation of rational functions using Löwner-based tensorization (2015)

A novel deterministic blind signal separation technique for separating signals into rational functions is proposed, applicable in various situations. This new technique is based on a tensorization of the observed data matrix into a set of Löwner matrices. The obtained tensor can then be decomposed with a block tensor decomposition, resulting in a unique separation into rational functions under mild conditions. This approach provides a viable alternative to independent component analysis (ICA) in cases where the independence assumption is not valid or where the sources can be modeled well by rational functions, such as frequency spectra. In contrast to ICA, this technique is deterministic and not based on statistics, and therefore works well even with a small number of samples.