gebhart/patrepeval huggingface dataset:
Characterization of an encapsulation device for the production of monodisperse alginate beads for cell immobilization (2000)

An encapsulation device, designed on the basis of the laminar jet break-up technique, is characterized for cell immobilization with different types of alginate. The principle of operation of the completely sterilizable encapsulator, together with techniques for the continuous production of beads from 250 microm to 1 mm in diameter, with a size distribution below 5%, at a flow rate of 1-15 mL/min, is described. A modification of the device, to incorporate an electrostatic potential between the alginate droplets and an internal electrode, results in enhanced monodispersity with no adverse effects on cell viability. The maximum cell loading capacity of the beads strongly depends on the nozzle diameter as well as the cells used. For the yeast Phaffia rhodozyma, it is possible to generate 700 microm alginate beads with an initial cell concentration of 1 x 10(8) cells/mL of alginate whereas only 1 x 10(6) cells/ml could be entrapped within 400 microm beads. The alginate beads have been characterized with respect to mechanical resistance and size distribution immediately after production and as a function of storage conditions. The beads remain stable in the presence of acetic acid, hydrochloric acid, water, basic water, and sodium ions. The latter stability applies when the ratio of sodium: calcium ions is less than 1/5. Complexing agents such as sodium citrate result in the rapid solubilization of the beads due to calcium removal. The presence of cells does not affect the mechanical resistance of the beads. Finally, the mechanical resistance of alginate beads can be doubled by treatment with 5-10 kDa chitosan, resulting in reduced leaching of cells.
Runtime FPGA partial reconfiguration (2008)

Field-programmable gate arrays (FPGAs) are now being integrated into many space-based applications. FPGAs are being used as replacements for application-specific integrated circuits (ASICs) without considering new options offered by their reprogrammable nature. Runtime partial reconfiguration can potentially reduce the number of devices or the device size, thereby reducing both size and power consumption. A system that requires either transmit or receive capabilities at any given time, but not both, can switch between the two modes in a fraction of a second using partial reconfiguration. The current approach requires that both modes be implemented simultaneously, thereby wasting power and requiring more resources. The idea of adaptively allocating limited FPGA resources is also applicable to hardware-accelerated software-defined radios. The hardware accelerators are loaded into FPGA(s) as they are needed. Partial reconfiguration allows swapping of accelerators much faster than is possible with current methods, and with less disruption to other processes running in parallel. This technology significantly reduces power consumption critical for space and portable ground-based applications of FPGA technology. A software-defined radio was designed with a reprogrammable forward error correction (FEC) block supporting multiple FEC codes to demonstrate one practical use of this technology. This paper provides an overview of the design flow necessary for partial reconfiguration and comments on the additional overhead necessary for creating such a design. In addition, limitations to this emerging technology are outlined.
Corrections to “Impact of the Quantum Well Gain-to-Cavity Etalon Wavelength Offset on the High Temperature Performance of High Bit Rate 980-nm VCSELs” [Aug 14 613-621] (2014)

In the above paper (ibid., vol. 50, no. 8, pp. 613-621, Aug. 2014), the sixth author was misidentified. His name should have read James A. Lott in the byline and in his biography.
Phosphonium Chloride Induced Dichlorosilylene Transfer from Trichlorosilane (2003)

Heating trichlorosilane with conjugated dienes or an acetylene solution at 150 or 180 °C in the presence of a catalytic quantity of tetrabutylphosphonium chloride resulted in elimination of HCl and dichlorosilylene transfer to the unsaturated substrates to afford silacyclopentenes or 1,4-disilacyclohexa-2,5-dienes, respectively, in good to excellent yields. The trapping reaction with hex-3-yne gave 1,1,4,4-tetrachloro-2,3,5,6-tetraethyl-1,4-disilacyclohexa-2,5-diene in 79% yield, and its structure was determined by X-ray crystallography.
Energy Levels of Cr3 + Ions in C3i Sites of Y3Al5O12 (1989)

Low-temperature (15 K) absorption spectra have been taken on two single crystals of Cr3+-doped Y3Al5O12 (YAG). The optical measurements were made on samples in the form of discs cut parallel to the (111) planes of the crystal. The absorption spectra were measured between 0.7 and 0.22 μm with a Cary Model 2390 spectrophotometer whose resolution was better than 1 A. The crystals contained 1.20 and 0.01 at. % chromiun based on aluminum.
Role of reinforcement in sintering of SiC/316L stainless steel composite (2000)

Austenitic stainless steels with improved corrosion resistance are gaining wide popularity. However, their applications are limited because of their poor tribological properties. The present work was undertaken to improve the overall performance of 316L stainless steel by reinforcing it with SiC. During the processing of the 316L SS composite, the 316L SS matrix was found to interact strongly with the SiC at 1100°C resulting in the formation of low melting Fe–SiC phase. An attempt to process SiC/316L SS composite above this temperature resulted in complete melting of the composite compact.
A rabbit model of hyperhomocysteinemia : the effect of homocysteine on blood clot structure and stability. (2004)

Hyperhomocysteinemia(Hhcys) is a condition that several epidemiological studies have shown to be associated with atherosclerosis and thrombosis, due to an elevation of plasma homocysteine levels. Plasma homocysteine(hcys) levels have a tendency to rise with age and changes in nutrition. Hcys can affect coagulation proteins, altering the formation of blood clots. The mechanism(s) by which hcys might cause modification of coagulation proteins "in vivo" is not understood. My hypothesis is that adult and juvenile animals could respond differently to chronic administration of hcys, and elevated plasma levels of hcys might lead to modification of fibrinogen "in vivo". Methodology: Six months old (juvenile, n=6) and 12 month old (adult, n=6) New Zealand White rabbits were divided into control (n=3) and homocysteine-treated (hcys-trt) (n=3) groups and injected for seven weeks; afterwards, they were given a bolus injection of hcys. Blood was drawn to evaluate plasma clearance of hcys. At the end, rabbits were exsanguinated by cardiac puncture and blood was collected for coagulation studies. Results: Juvenile hcys-trt rabbits adapted to chronic administration of hcys, however, adult hcys-trt rabbits developed Hhcys. Adult hcys-trt rabbits had higher levels of malonaldehyde in liver tissue, which is evidence of oxidative stress. Juvenile hcys-trt rabbits had similar malonaldehyde levels as juvenile control rabbits. Plasma elimination of hcys was impaired in adult hcys-trt rabbits. Adult hcys-trt rabbits had increased fibrinogen levels, longer reptilase times, and shorter thrombin clotting times versus adult control rabbits. Clots formed from purified fibrinogen obtained from hcys-trt rabbits lysed slower than comparable clots formed from control rabbits purified fibrinogen. Some congenital dysfibrinogenemias have clots that are abnormally resistant to fibrinolysis due to alterations in fibrinogen structure, and lead to recurrent thrombosis. Clotting results for adult hcys-trt rabbits suggest that hyperhomocysteinemia leads to a similar acquired dysfibrinogenmia. Therefore, the prolonged reptilase times and formation of clots that are abnormally resistant to fibrinolysis could directly contribute to increased risk of thrombosis in hyperhomocysteinemia.
A STUDY OF SUPERACID SOLUTIONS. II. A CHEMICAL INVESTIGATION OF THE HYDROGEN-ION ACTIVITY OF ACETIC ACID SOLUTIONS (1927)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA STUDY OF SUPERACID SOLUTIONS. II. A CHEMICAL INVESTIGATION OF THE HYDROGEN-ION ACTIVITY OF ACETIC ACID SOLUTIONSJames B. Conant and Norris F. HallCite this: J. Am. Chem. Soc. 1927, 49, 12, 3062–3070Publication Date (Print):December 1, 1927Publication History Published online1 May 2002Published inissue 1 December 1927https://pubs.acs.org/doi/10.1021/ja01411a011https://doi.org/10.1021/ja01411a011research-articleACS PublicationsRequest reuse permissionsArticle Views331Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Morton D. Sarver, O.D., M.S (1986)

School of Optometry, University of California, Berkeley, California * Optometrist, M.S., J.D., Member of Faculty, F.A.A.O. † Optometrist, Ph.D, Member of Faculty, F.A.A.O. AUTHORS' ADDRESS: Michael G. Harris Jay M. Enoch School of Optometry University of California, Berkeley Berkeley, California 94720 AUTHOR'S ADDRESS: Constantine J. Forkiotis Connecticut State Police Surgeon Member, National Advisory Panel on Driving With Influence Research and Special Programs United States Department of Transportation National Highway Traffic Safety Administration 437 Tunxis Hill Road Fairfield, Connecticut 06430
Reprogramming epigenetic silencing: artificial transcription factors synergize with chromatin remodeling drugs to reactivate the tumor suppressor mammary serine protease inhibitor (2008)

Mammary serine protease inhibitor (maspin) is an important tumor suppressor gene whose expression is associated not only with tumor growth inhibition but also with decreased angiogenesis and metastasis. Maspin expression is down-regulated in metastatic tumors by epigenetic mechanisms, including aberrant promoter hypermethylation. We have constructed artificial transcription factors (ATFs) as novel therapeutic effectors able to bind 18-bp sites in the maspin promoter and reactivate maspin expression in cell lines that harbor an epigenetically silenced promoter. In this article, we have investigated the influence of epigenetic modifications on ATF-mediated regulation of maspin by challenging MDA-MB-231 breast cancer cells, comprising a methylated maspin promoter, with different doses of ATFs and chromatin remodeling drugs: the methyltransferase inhibitor 5-aza-2'-deoxycytidine and the histone deacetylase inhibitor suberoylanilide hydroxamic acid. We found that the ATFs synergized with both inhibitors in reactivating endogenous maspin expression. The strongest synergy was observed with the triple treatment ATF-126 + 5-aza-2'-deoxycytidine + suberoylanilide hydroxamic acid, in which the tumor suppressor was reactivated by 600-fold. Furthermore, this combination inhibited tumor cell proliferation by 95%. Our data suggest that ATFs enhance the efficiency of chromatin remodeling drugs in reactivating silenced tumor suppressors. Our results document the power of a novel therapeutic approach that combines both epigenetic and genetic (sequence-specific ATFs) strategies to reactivate specifically silenced regions of the genome and reprogram cellular phenotypes.
Asymmetric Hydrogenation of Aromatic Olefins Catalyzed by Iridium Complexes of Proline‐Derived Phosphine—Oxazoline Ligands. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Elimination of phosphate and zirconium in the high-activity fraction resulting from TRUEX partitioning of ICPP zirconium calcines (1997)

Laboratory testing was undertaken with the aim of developing a TRUEX flowsheet that would efficiently remove actinides from solutions of dissolved zirconium calcine and minimize the glass volume produced from the ensuing high-activity fraction. A TRUEX flowsheet is recommended for testing in the 2-cm centrifugal contactor pilot-plant based on the results from this testing. These laboratory tests show that zirconium recovery in the high activity fraction is minimized by scrubbing with an optimized NHF concentration of 0.2 M. This NH4F concentration in the scrub allowed the HEDPA strip concentration to be reduced from 0.04 M to 0.004 M because HEDPA is not consumed by zirconium. Complete TRU stripping was also achieved in these laboratory tests with 0.004 M HEDPA. Data from the small-scale laboratory batch contact tests were used in the Generic TRUEX Model (GTM) to evaluate the proposed flowsheet under counter-current conditions. GTM results indicate the raffinate will meet the Class A non-TRU limit of < 10 nCi/g in six extraction stages (O/A = 1), and quantitative actinide recovery will be achieved with the 0.004 M HEDPA in six strip stages (O/A = 1). Only 6.6 % of the initial zirconium concentration is anticipated to be recovered with the actinides, indicating the four scrub stages (O/A = 3) efficiently removes zirconium from the TRUEX solvent. In addition to recommending an improved TRUEX flowsheet for testing in the 2-cm centrifugal contactor pilot-plant, this work has shown that small reductions in zirconium extraction drastically improves flowsheet performance. These small changes in zirconium extraction can be accomplished by modifying the calcine dissolution parameters. Therefore, further calcine dissolution testing followed by TRUEX testing with the resulting feed solutions is also recommended.
Town Crier: An Authenticated Data Feed for Smart Contracts. (2016)

Smart contracts are programs that execute autonomously on blockchains. Their key envisioned uses (e.g. financial instruments) require them to consume data from outside the blockchain (e.g. stock quotes). Trustworthy data feeds that support a broad range of data requests will thus be critical to smart contract ecosystems. We present an authenticated data feed system called Town Crier (TC). TC acts as a bridge between smart contracts and existing web sites, which are already commonly trusted for non-blockchain applications. It combines a blockchain front end with a trusted hardware back end to scrape HTTPSenabled websites and serve source-authenticated data to relying smart contracts. TC also supports confidentiality. It enables private data requests with encrypted parameters. Additionally, in a generalization that executes smart-contract logic within TC, the system permits secure use of user credentials to scrape access-controlled online data sources. We describe TC’s design principles and architecture and report on an implementation that uses Intel’s recently introduced Software Guard Extensions (SGX) to furnish data to the Ethereum smart contract system. We formally model TC and define and prove its basic security properties in the Universal Composability (UC) framework. Our results include definitions and techniques of general interest relating to resource consumption (Ethereum’s “gas” fee system) and TCB minimization. We also report on experiments with three example applications. We plan to launch TC soon as an online public service.
Three-dimensional structure of a polymer/clay nanocomposite characterized by transmission electron microtomography (2006)

Three-dimensional (3D) morphology of a polymer/clay nanocomposite, an organophilic montmorillonite (MMT) dispersed in poly(ethylene-co-vinylacetate) (EVA), was examined by transmission electron microtomography (TEMT). Using this technique, individual clay layers dispersed in the EVA matrix were clearly visualized. A volume fraction of the clay layers evaluated from the 3D reconstructed image agreed well with that calculated from the weight of the MMT component in the MMT/EVA system. The individual clay layers were digitally extracted by a newly developed 3D particle algorithm. A size distribution of the clay layers was directly obtained from the 3D reconstruction. Anisotropy of each clay layer was characterized by the determination of three semi-axes of an approximating ellipsoid with the same volume. One of the representative semi-axis of the ellipsoid was used to estimate average orientation of the MMT layers in the ultra-thin section used in the TEMT experiment. Thus, the combination of quantitative TEMT and 3D structural analysis is shown to be a powerful tool to investigate a relationship between the MMT distribution and a variety of physical properties of the nanocomposites.
Pissing in Good Company (2006)

In lieu of an abstract, below is the essay's first paragraph.\n"Sleepy Hollow Cemetery opens at 7 in the morning,\nso I arrrived before 5 intent on some contemplation\nprolonged and private, a plan of some merit but less\nwell executed since by the tirne I'd found Emerson's\ngrave on Authors Ridge my bladder was ready to burst,"
Avian Paramyxoviruses Other Than Newcastle Disease Virus (2019)

Covers all the important avian viruses over thirteen chapters. Examples include: avian influenza virus, avian adenovirus, Marek's disease virus, avian reovirus, avian pox virus, avian leukosis virus, avian metapneumovirus, avian paramyxovirus. Closes with a chapter on the avian immune responses to virus infection.
Striatal D2 receptor status in patients with Parkinson's disease, striatonigral degeneration, and progressive supranuclear palsy, measured with 11C‐raclopride and positron emission tomography (1992)

Equilibrium striatal: cerebellar 11C-raclopride (RAC) uptake ratios reflect the density of striatal dopamine D2 binding sites. Using positron emission tomographic scanning we have measured striatal RAC uptake in 6 untreated patients with Parkinson's disease (PD), 5 chronically treated patients with PD and a fluctuating response to L-dopa, 10 patients with striatonigral degeneration (SND), and 9 patients with progressive supranuclear palsy (PSP). Regional cerebral blood flow was determined also, with C15O2. Mean striatal: cerebellar RAC uptake was not significantly different from normal in untreated patients with PD, though 2 of these 6 patients showed significantly increased putamen tracer binding. Mean caudate and putamen: cerebellar RAC uptake ratios of the group with PD and a fluctuating response to L-dopa were significantly reduced by 30% and 18%, respectively. The patients with SND had lesser, but significant, 10% and 11% decreases in mean caudate and putamen: cerebellar RAC uptake ratios, respectively, whereas patients with PSP showed 24% and 9% reductions in caudate and putamen: cerebellar RAC binding. Striatal and frontal blood flow were significantly reduced in patients with PSP, but not in patients with PD or SND. In conclusion, striatal D2 binding potential is normal or raised in untreated patients with PD, but reduced in patients with PD and a fluctuating response to L-dopa. Patients with SND and PSP show a decrease in striatal RAC binding, but to a lesser extent than patients with PD and a fluctuating response to treatment.(ABSTRACT TRUNCATED AT 250 WORDS)
Molecular mechanisms in DM1 — a focus on foci (2015)

Myotonic dystrophy type 1 is caused by abnormal expansion of a CTG-trinucleotide repeat in the gene encoding Dystrophia Myotonica Protein Kinase (DMPK), which in turn leads to global deregulation of gene expression in affected individuals. The transcribed mRNA contains a massive CUG-expansion in the 3' untranslated region (3'UTR) facilitating nucleation of several regulatory RNA-binding proteins, which are thus unable to perform their normal cellular function. These CUG-expanded mRNA-protein aggregates form distinct, primarily nuclear foci. In differentiated muscle cells, most of the CUG-expanded RNA remains in the nuclear compartment, while in dividing cells such as fibroblasts a considerable fraction of the mutant RNA reaches the cytoplasm, consistent with findings that both nuclear and cytoplasmic events are mis-regulated in DM1. Recent evidence suggests that the nuclear aggregates, or ribonuclear foci, are more dynamic than previously anticipated and regulated by several proteins, including RNA helicases. In this review, we focus on the homeostasis of DMPK mRNA foci and discuss how their dynamic regulation may affect disease-causing mechanisms in DM1.
Supplementary Tables S1-S3 from EBV-Related Lymphoproliferative Disease Complicating Therapy with the Anti-CD2 Monoclonal Antibody, Siplizumab, in Patients with T-Cell Malignancies (2023)

Supplementary Tables S1-S3 from EBV-Related Lymphoproliferative Disease Complicating Therapy with the Anti-CD2 Monoclonal Antibody, Siplizumab, in Patients with T-Cell Malignancies
Epigenetic Modulation in Hematologic Malignancies: Challenges and Progress (2009)

Genetic alterations, including gene mutations, and chromosomal amplifications, deletions, inversions, and translocations, are hallmarks of the molecular biology of cancer. These events lead to oncogene activation, formation of chimeric oncoproteins, and/or inactivation of tumor suppressor genes. Such genetic changes contribute to the neoplastic transformation of cells, as well as the eventual acquisition by malignant cells of a more aggressive biologic and clinical behavior. However, in recent years, it has become apparent that these genetic events are not the sole determinants of the biologic behavior of tumor cells. Indeed, it is becoming increasingly apparent that tumor cells with a given genotype exhibit a differential phenotype depending on the microenvironment in which they reside. Furthermore, extensive data have shown that derivative daughter cells of neoplastic, as well as normal cells, inherit changes in the patterns of gene expression that are not associated with changes in the primary DNA sequence but are instead related to changes in chromatin structure and its accessibility for transcriptional activity. These heritable gene expression changes that are not associated with changes in the primary nucleotide sequence are referred to as epigenetic changes. This review provides an overview of the regulation of the "epigenome" in neoplastic cells, with particular emphasis on DNA methylation and histone acetylation as therapeutic targets for hematologic malignancies.
Synthèse et réactivité thermique de polycarbosilanes fonctionnels et complexes à des métaux de transition (1993)

Ce memoire presente les differences de reactivites thermiques entre des polycarbosilanes de formules (c#2h#4sir#2)#n et (c#2h#4sir#2sir#2)#n, suivant la nature des substituants a l'atome de silicium: r=h ou me, ou complexes a un metal de transition. La fonction hydrosilane abaisse la stabilite thermique des polycarbosilanes. Les sites fonctionnels, =sih#2 ou =sih-si, generent, suivant des reactions de 1-1 elimination, des intermediaires silylenes qui reticulent le polymere au debut de la pyrolyse avant la mineralisation. La reactivite thermique de la fonction hydrosilane peut aussi etre activee par complexation avec le cobalt carbonyle. Le produit de complexation du pvs (c#2h#4sih#2)#n avec co#2(co)#8 presente une reactivite a la thermolyse, tres differente de celle du pvs. La reticulation du precurseur pvs-cobaltcarbonyle intervient des 150c, suivant un processus faisant intervenir des complexes silylenes de cobalt carbonyle