gebhart/patrepeval huggingface dataset:
Virtual machine migration implementation in load balancing for Cloud computing (2014)

The demand for Cloud computing usage is increasing day by day due to the advantages and facilities it offers. The fast growing rate of the usage of large-scale computing machines on cloud platform has resulted in increased consumption of energy and emission of carbon. Such negative effects should be curbed for a more environmental-friendly computing platform, e.g. a green cloud computing platform. Scheduling is one of the aspects that can be looked into in regards to the improvement of the whole cloud architecture, specifically in the scope of resource management. One of the important features that need to be optimized in regards to scheduling is the load balancing process that emphasizes on optimal resource utilization, maximum throughput, maximum response time and prevention of overload. One way to optimize the load balancing process is by implementing the migration of virtual machines across multiple hosts, in which utilization of CPU resources can be optimized. The appropriate use of two different classes of resources e.g. low-powered and high-powered machines based on their Million Instructions Per Second (MIPS) metrics, will lead to minimal process execution time if both types of resources are being efficiently used and effectively mapped to suitable types of processing. According to different machine performance, the migration of virtual machines will be computed based on the current CPU utilization following three different conditions, i.e. when the CPU usage reaches its 90%, 10% and 0% marker. Based on this idea, a general algorithm in activating the virtual machine migration is proposed, in which the overall load balancing process could be improved.
VM/370 asymmetric multiprocessing (1979)

In undertaking an effort like the one described herein, there are many decisions to be made and pitfalls to be avoided. It is hoped that some insight has been gained into the problem of adding a major new function to an operating system that did not provide for that function originally. It is gratifying to see the results of that labor operating in production environments and performing up to its objectives.
Growth process for high performance of InGaAs MOSFETs (2014)

To obtain high performance in nMOSFETs, the introduction of high-mobility channel material such as InGaAs is a promising approach. However, the required source doping concentration for a high driving current cannot be obtained by ion implantation in InGaAs. One method of achieving a heavily doped source in III–V semiconductor MOSFETs is by growing an epitaxial source/drain structure. <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> For realizing such a source, we used a regrown InGaAs source <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2,3</sup> and an InP source. <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sup> The regrown sources are also important for high current drivability of 3D or multi-gate devices. The other advantage of regrowth in multi-gate devices is a smooth surface for high electron mobility. <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sup> In this report, we describe the growth process for high-performance InGaAs MOSFETs.
p38 mitogen‐activated protein kinase (MAPK) first regulates filamentous actin at the 8–16‐cell stage during preimplantation development (2005)

Murine preimplantation development becomes dependent on p38 MAPK at the 8-16-cell stage, which corresponds to the stage when p38 MAPK first regulates filamentous actin during early development.
The Flood Myth and the Origin of Ethnic Groups in Southeast Asia (1993)

Virtually every ethnic group in mainland Southeast Asia tells myths of a great deluge that leaves only two survivors alive to reconstitute humanity and to create the ethnic groups of the region. The survivors - typically a brother and sister, or a woman and dog - must consummate an abnormal marriage ; from the incestuous match is born a gourd or a gourd-shaped lump of flesh. The gourd in turn is the source of the various ethnic groups of the locality. With a collection of more than 300 such myths encountered during recent field research throughout Vietnam, the A. traces the main elements of the myth and presents its major variants. The myth in its many forms offers a unique window onto the cultural traditions of mainland Southeast Asia.
SOME PROPERTIES OF SILICA DISPERSIONS (1960)

When silicic acid sols are formed from solutions of sodium silicate by acid neutralization, a pronounced minimum in the time required for the sol–gel transformation is observed if the titration is stopped near pH 8. If the sol is prepared by electrodialysis, a similar minimum is obtained when the operation is stopped at about pH 5.5. Intermediate values for the minimum are found if the original silicate solution is partially dialyzed followed by neutralization with acid. When the water content of the gels is replaced by liquid hydrocarbons, maximum interaction between the silica particles occurs when the aqua gel has been formed or conditioned at pH 5.5 regardless of the method of preparation of the sol. A minimum in electrophoretic mobility and a maximum in sedimentation rate of the particles are observed at a similar pH value. These properties are modified considerably if the system is thoroughly dehydrated.
Sur un nouveau mode de couplage entre les aimantations de deux couches minces ferromagnétiques (1962)

International audience
Purposeful Misalignment of Severed Nerve Stumps in a Standardized Transection Model Reveals Persistent Functional Deficit With Aberrant Neurofilament Distribution (2021)

These findings in a novel nerve transection mouse model with misaligned repair suggest that aberrant neurofilament distributions and axonal misdirections play an important role in functional recovery and muscle atrophy.
DRENCH: A semi-distributed resource management framework for NFV based service function chaining (2017)

As networks grow in scale and complexity, the use of Network Function Virtualization (NFV) and the ability to dynamically instantiate network function instances (NFls) allow us to scale out the network's capabilities in response to demand. At the same time, an increasing number of computing resources, deployed closer to users, as well as network equipment are now capable of performing general-purpose computation for NFV. However, NFV management in the presence of Service Function Chaining (SFC) for arbitrary topologies is a challenging task. In this work we argue for the necessity of an algorithmic resource managementframework that captures the involved tradeoffs of NFls minimum workload, load balancing, and flow path stretch. We introduce DRENCH as a low complexity NFV and flow steering management framework. In DRENCH an NFV market is considered where a centralised SDN controller acts as market orchestrator of NFV nodes. Through competition, NFV nodes make flow steering and NFl instantiation/consolidation decisions. DRENCH design enables third party NFV nodes participation while it can coexist with other NFV management solutions. DRENCH orchestrator parameterisation strikes the right balance between path stretch and NFl load balancing, resulting in significantly lower Flow Completion Times, up to 1Ox less, in some cases.
Sudden cardiac death in diabetes mellitus: risk factors in the Rochester diabetic neuropathy study (2005)

Sudden cardiac death was correlated with atherosclerotic heart disease and nephropathy, and to a lesser degree with DAN and HDL cholesterol. Although DAN is associated with sudden cardiac death, it is unlikely to be its primary cause.
IN-VEHICLE INFORMATION SYSTEMS BEHAVIORAL MODEL AND DESIGN SUPPORT: FINAL REPORT (2000)

A great deal of effort went into producing both the model and the prototype software for this contract. The purpose of this final report is not to duplicate the information provided about these and other topics in previous reports. The purpose is to summarize the important aspects of this project and to finalize the model and software prototype description not covered thoroughly in previous reports. This final report of the contract will summarize the following: a description of the behavioral model; the four studies that were conducted to supplement the research needed for the model; how tasks from the literature were modeled and included in the prototype software; the prototype software and some of its main modules; recommendations for next steps; the titles and a brief summary of each of the previous reports written for this project.
Organization of response areas in ferret primary auditory cortex (1993)

1. We studied the topographic organization of the response areas obtained from single- and multiunit recordings along the isofrequency planes of the primary auditory cortex in the barbiturate-anesthetized ferret. 2. Using a two-tone stimulus, we determined the excitatory and inhibitory portions of the response areas and then parameterized them in terms of an asymmetry index. The index measures the balance of excitatory and inhibitory influences around the best frequency (BF). 3. The sensitivity of responses to the direction of a frequency-modulated (FM) tone was tested and found to correlate strongly with the asymmetry index of the response areas. Specifically, cells with strong inhibition from frequencies above the BF preferred upward sweeps, and those from frequencies below the BF preferred downward sweeps. 4. Responses to spectrally shaped noise were also consistent with the asymmetry of the response areas. For instance, cells that were strongly inhibited by frequencies higher than the BF responded best to stimuli that contained least spectral energy above the BF, i.e., stimuli with the opposite asymmetry. 5. Columnar organization of the response area types was demonstrated in 66 single units from 16 penetrations. Consistent with this finding, it was also shown that response area asymmetry measured from recordings of a cluster of cells corresponded closely with those measured from its single-unit constituents. Thus, in a local region, most cells exhibited similar response area types and other response features, e.g., FM directional sensitivity. 6. The distribution of the asymmetry index values along the isofrequency planes revealed systematic changes in the symmetry of the response areas. At the center, response areas with narrow and symmetric inhibitory sidebands predominated. These gave way to asymmetric inhibition, with high-frequency inhibition (relative to the BF) becoming more effective caudally and low-frequency inhibition more effective rostrally. These response types tended to cluster along repeated bands that paralleled the tonotopic axis. 7. Response features that correlated with the response area types were also mapped along the isofrequency planes. Thus, in four animals, a map of FM directional sensitivity was shown to be superimposed on the response area map. Similarly, it was demonstrated in six animals that the spectral gradient of the most effective noise stimulus varied systematically along the isofrequency planes. 8. One functional implication of the response area organization is that cortical responses encode the locally averaged gradient of the acoustic spectrum by their differential distribution along the isofrequency planes. This enhances the representation of such features as the symmetry of spectral peaks and edges and the spectral envelope.(ABSTRACT TRUNCATED AT 400 WORDS)
International Study of Expert Judgment on Therapeutic Use of Benzodiazepines and Other Psychotherapeutic Medications: IV. Therapeutic Dose Dependence and Abuse Liability of Benzodiazepines in the Long-Term Treatment of Anxiety Disorders (1999)

Despite decades of relevant basic and clinical research, active debate continues about the appropriate extent and duration of benzodiazepine use in the treatment of anxiety and related disorders. The primary basis of the controversy seems to be concern among clinicians, regulators, and the public about the dependence potential and the abuse liability of benzodiazepines. This article reports systematically elicited judgments on these issues by a representative panel of 73 internationally recognized experts in the pharmacotherapy of anxiety and depressive disorders, a panel which was constituted by a multistage process of peer nomination. The criterion for inclusion at each stage was the nomination by at least two peers as one of the "professionally most respected physicians of the world with extensive experience and knowledge in the pharmacotherapy of anxiety and depressive disorders." Sixty-six respondents (90%) completed a comprehensive questionnaire covering a wide range of topics relevant to the therapeutic use of benzodiazepines and other medications that might be used for the same purposes. Overall, the expert panel judged that benzodiazepines pose a higher risk of dependence and abuse than most potential substitutes but a lower risk than older sedatives and recognized drugs of abuse. There was little consensus about the relative risk of dependence and abuse among the benzodiazepines. Differences between benzodiazepines with shorter and longer half-lives in inducing withdrawal symptoms are much less clear during tapered than during abrupt discontinuation. There was little agreement about the most important factors contributing to withdrawal symptoms and failure to discontinue benzodiazepines. The pharmacologic properties of the medication may be the most important contributors to withdrawal symptoms. In contrast, the clinical characteristics of the patient may be the most important contributors to failure to discontinue medication. The experts' judgment seems to support the widespread use of benzodiazepines for the treatment of bona fide anxiety disorders, even over long periods. The experts generally viewed dependence and abuse liability as clinical issues amenable to appropriate management, as for other adverse events related to therapy. However, more definitive clinical research on the remaining controversial issues is urgently needed to promote optimal patient care.
Affinity interactions of Actin with HS1 and Annexin I, II, IV, V and VI in RAW264.7 macrophages in vitro and in the Fc-receptor complex (2021)

Actin binding proteins HS1 and Annexin I, II, III, IV, V and VI proteins were examined in RAW macrophages in vitro using affinity chromatography, LC-MS/MS, western blot, cell staining and expression of fluorescent proteins. Actins and many related actin isoforms were observed in the phagosome. However, actins were also observed on polystyrene beads incubated with crude extracts readily bound to NHS affinity chromatography beads in the absence of anti-actin antibodies. Annexin II and V and the haematopoietic specific proteins HS1 (also called Lyn substrate) were prominently observed in isolated phagosomes and not observed in control beads incubated with crude extracts of RAW macrophages. Annexin II and V as well as G3BP, FLT1, FARP2, STARD13, RAB25, and FRAP1 were observed to bind actin in affinity chromatography experiments using LC-MS/MS and western blot. Cell staining and/or expression of GFP constructs showed that actin, HS1 and Annexin V prominently accumulate at the nascent Fc-receptor complex of RAW macrophages.
David Malouf: The long breath of the young writer (2014)

Malouf's juvenilia and early adult writing have not yet received scholarly attention. While briefly considering five of his short stories published between 1948 and 1955, this article argues that themes that stretch across the 'longer breath' of his works, such as a character's struggle for survival and quest for happiness, are apparent from the time of his schoolboy writing just after World War II. The kinds of life-accounting that Malouf grew up with may have influenced the narrative forms with which the young writer experimented, a view of juvenilia put forward by Alexander (2005) and Eakin (1999). The influence of cinema and modernist authors becomes apparent as his enters his twenties, together with the personal 'writing school' he discovered in reading Sean O'Faolain's 'The Short Story'. A reassessment is needed of the general view that Malouf is a poet first who came later to prose, given the evidence of these carefully crafted stories.
Ethics and Regulations for Cardiovascular Diseases (2021)

Ethics deals with human values and conduct, with respect to right and wrong in certain motives. The rapid development of therapeutics has raised a number of ethical issues pertaining to philosophical, legal, religious and moral beliefs. With the advancement of science, inclusion of ethical values is of absolute necessity in different aspects of clinical practice. The introduction of nanotechnology has helped in fighting many complex illnesses, including cardiovascular diseases. Nanotechnology may provide a solution for better prognoses and a reduced side effect. In this regard, cardiovascular therapeutic involvement needs a testimony with respect to societal benefits for developing a code of ethics.
Labile Sulfur in Human Superoxide Dismutase (1975)

1. The nautre of the intense absorption band at 320 nm of the copper and zinc-containing enzyme superoxide dismutase, from human red blood cells, has been investigated. The band does not depend on the metal prosthetic groups of the enzyme, as it is still present in the apo protein. When, however, copper alone is removed from the enzyme with a treatment involving the use of cyanide, the band is also lost. Nevertheless the copper-free protein is able to recover both the enzyme activity and the native electron paramagnetic resonance spectrum as easily as the apo protein. 2. A number of other treatments are able to abolish the band. They include reaction with reducing agents such as dithiothreitol, sulfite, borohydride, exposure to denaturants such as guanidine HCl and sodium dodecyl sulfate, and exposure to pH values below pH 3 or above pH 13. 3. Four sulfur atoms per protein molecule were found to be associated to the 320-nm chromophore on the basis of quantitative determinations following reaction with cyanide or sodium borohydride. 4. A molar absorption coefficient of 1150 M-1 cm-1 was determined per each chromophoric group. In spite of this relatively high value and unusual stability, a persulfide group, R-S-SH, seems to be the most likely structure for this chromophore. 5. Bovine and equine superoxide dismutase do not show spectral or chemical evidence for such a group. This, and the recovery of activity and spectral properties of copper in the cyanide-treated human enzyme, indicate that labile sulfur is not associated with the superoxide dismutase activity of this protein.
Dataset for: Cluster Detection of Spatial Regression Coefficients (2017)

Popular approaches to spatial cluster detection, such as the spatial scan statistic, are defined in terms of the responses. Here, we consider a varying-coefficient regression and spatial clusters in the regression coefficients. For varying-coefficient regression, such as the geographically weighted regression, different regression coefficients are obtained for different spatial units. It is often of interest to the practitioners to identify clusters of spatial units with distinct patterns in a regression coefficient, but there is no formal statistical methodology for that. Rather, cluster identification is often ad-hoc such as by eyeballing the map of fitted regression coefficients and discerning patterns. In this paper, we develop new methodology for spatial cluster detection in the regression setting based on hypotheses testing. We evaluate our methods in terms of power and coverages for true clusters via simulation studies. For illustration, our methodology is applied to a cancer mortality dataset.
Targeting FAK scaffold functions inhibits human renal cell carcinoma growth (2015)

Human conventional renal cell carcinoma (CCC) remains resistant to current therapies. Focal Adhesion Kinase (FAK) is upregulated in many epithelial tumors and clearly implicated in nearly all facets of cancer. However, only few reports have assessed whether FAK may be associated with renal tumorigenesis. In this study, we investigated the potential role of FAK in the growth of human CCC using a panel of CCC cell lines expressing or not the von Hippel-Lindau (VHL) tumor suppressor gene as well as normal/tumoral renal tissue pairs. FAK was found constitutively expressed in human CCC both in culture cells and freshly harvested tumors obtained from patients. We showed that CCC cell growth was dramatically reduced in FAK-depleted cells or after FAK inhibition with various inhibitors and this effect was obtained through inhibition of cell proliferation and induction of cell apoptosis. Additionally, our results indicated that FAK knockdown decreased CCC cell migration and invasion. More importantly, depletion or pharmacological inhibition of FAK substantially inhibited tumor growth in vivo. Interestingly, investigations of the molecular mechanism revealed loss of FAK phosphorylation during renal tumorigenesis impacting multiple signaling pathways. Taken together, our findings reveal a previously uncharacterized role of FAK in CCC whereby FAK exerts oncogenic properties through a non canonical signaling pathway involving its scaffolding kinase-independent properties. Therefore, targeting the FAK scaffold may represent a promising approach for developing innovative and highly specific therapies in human CCC.
Il ruolo della programmazione nella neuromodulazione sacrale (2006)

THE ROLE OF PROGRAMMING IN SACRAL NEUROMODULATION. Abstract: Sacral Neuromodulation therapy is a well established treatment for various types of voiding dysfunctions. There are no ideal para- meters that could be recommended when applying this treatment nor there are clear guidance's on how the parameters should be selected or even adjusted for different patient populations. This was a prospective study that was on patients who underwent Interstim implantation for chronic voiding dysfunctions. The goal of the study was to identify an optimal parameter setting for each specific voiding disorder. We founded a significant inverse correlation between number of reprogramming and % of clinical improvement. The unipolar configuration showed a better correlation with a successful treatment in all the groups of patients. In conclusion each reprogramming is patient specific and indipendent regarding the voiding dysfunction.
Efficient Light-Harvesting Antenna with a Multi-Porphyrin Cascade (2011)

A light-harvesting antenna 1 comprising three varieties of porphyrins, each having a different number of ethynyl groups at its meso positions, was designed and synthesized. Antenna 1 exhibits intense absorption throughout the visible region up to 700 nm. Steady-state and time-resolved fluorescence studies showed that singlet-excited-state energy transfer occurs from the peripheral porphyrins to the central porphyrin with >90% efficiency and rate constants on the order of 10(10) s(-1).