gebhart/patrepeval huggingface dataset:
Visible-Light Auto-Catalyzed Transformation in Naphthylamines and their Spiroacridines (2022)

Visible-light-induced self-sensitization reaction are of crucial importance to understand the biological color mechanism and defect-triggered accelerating degradation and to design photocatalysis for practical application. Here, we discovered a visible-light auto-catalyzed transformation in naphthylamines and their spiroacridines. A series of spiro[fluorene-9,7'-dibenzo[c,h]acridine]-5'-one (SFDBAO) derivatives have been concisely and cleanly obtained by directly irradiating sunlight in the higher yields than that when using a UV lamp. An interesting auto-catalysed and self-sensitive procedure has been proposed to explain the effective photooxygenation. Air atmosphere and sunlight irradiations are crucial conditions of the photooxygenation reaction to obtain the high-yield products. SFDBAO derivatives exhibit the continuous \(\pi\)-stacking motifs in single-crystal and electron-withdraw properties with potential red light-emitting and photovoltaic properties.
A histone deacetylase inhibitor, largazole, decreases liver fibrosis and angiogenesis by inhibiting transforming growth factor‐β and vascular endothelial growth factor signalling (2012)

Our findings revealed a novel role of largazole in the treatment of liver fibrosis. Through multiple mechanisms, largazole could be a potentially effective antifibrotic agent.
Role and mutational heterogeneity of the p53 gene in hepatocellular carcinoma. (1993)

The mutational spectrum of the p53 gene was analyzed in 53 hepatocellular carcinomas. Somatic mutations of the p53 gene were detected in 17 cases (32%). Among these 17 mutations, 9 were missense mutations; the mutations in the other 8 cases were nonsense mutations, deletions, or mutations at the intron-exon junctions. These mutations were found in a wide region stretching from exon 4 to exon 10 without any single mutational hot spot. G:C to T:A transversions were predominant, suggesting the involvement of environmental mutagens in the mutagenesis of the p53 gene in a subset of the hepatocellular carcinoma cases. Mutations of the p53 gene occurred frequently in advanced tumors, although several tumors in the early stages also showed mutations. A deletion map of chromosome 17 was constructed by using 10 polymorphic probes and was compared with the p53 gene mutation in each case. Loss of heterozygosity (LOH) on chromosome 17p was observed in 49% of the cases (24 of 49), and two commonly deleted regions were detected (around the p53 locus and at 17p13.3 to the telomere). Sixteen of the 17 cases with p53 gene mutations showed LOH around the p53 locus, and mutations were rare in hepatocellular carcinomas without LOH. However, no mutations were detected in 8 cases with LOH on 17p, suggesting the possibility that an unidentified tumor suppressor gene(s) located on 17p may have also been involved in hepatocarcinogenesis.
Fabrication and Optical Properties of Strain-free Self-assembled Mesoscopic GaAs Structures (2017)

We use a combined process of Ga-assisted deoxidation and local droplet etching to fabricate unstrained mesoscopic GaAs/AlGaAs structures exhibiting a high shape anisotropy with a length up to 1.2 μm and a width of 150 nm. We demonstrate good controllability over size and morphology of the mesoscopic structures by tuning the growth parameters. Our growth method yields structures, which are coupled to a surrounding quantum well and present unique optical emission features. Microscopic and optical analysis of single structures allows us to demonstrate that single structure emission originates from two different confinement regions, which are spectrally separated and show sharp excitonic lines. Photoluminescence is detected up to room temperature making the structures the ideal candidates for strain-free light emitting/detecting devices.
Investigations of modal instabilities in fiber amplifiers through detailed numerical simulations (2013)

We present detailed numerical simulations of modal instabilities in high-power Yb-doped fiber amplifiers using a time-dependent temperature solver coupled to the optical fields and population inversion equations. The temperature is computed by solving the heat equation in polar coordinates using a 2D second-order alternating direction implicit method. We show that the higher-order modal content rises dramatically in the vicinity of the threshold and we recover the three power-dependent regions that are characteristic of the transfer of energy. We also investigate the dependence of the threshold on the seed power and the modal content ratio of the seed. The latter has a minimal effect on the threshold while it is shown that for the fiber configuration investigated, the modal instability threshold scales linearly over a wide range with the seed power. In addition, two different gain-tailored core designs are investigated and are shown to have higher thresholds than that of a uniformly doped core. Finally, we show that this full time-dependent model which does not assume a frequency offset between the modes a priori, predicts a reduced threshold when the seed is modulated at the KHz level. This is in agreement with the steady-periodic approach to this phenomenon.
Liquid Metal Electrodes for Energy Storage Batteries (2016)

The increasing demands for integration of renewable energy into the grid and urgently needed devices for peak shaving and power rating of the grid both call for low‐cost and large‐scale energy storage technologies. The use of secondary batteries is considered one of the most effective approaches to solving the intermittency of renewables and smoothing the power fluctuations of the grid. In these batteries, the states of the electrode highly affect the performance and manufacturing process of the battery, and therefore leverage the price of the battery. A battery with liquid metal electrodes is easy to scale up and has a low cost and long cycle life. In this progress report, the state‐of‐the‐art overview of liquid metal electrodes (LMEs) in batteries is reviewed, including the LMEs in liquid metal batteries (LMBs) and the liquid sodium electrode in sodium‐sulfur (Na–S) and ZEBRA (Na–NiCl 2 ) batteries. Besides the LMEs, the development of electrolytes for LMEs and the challenge of using LMEs in the batteries, and the future prospects of using LMEs are also discussed.
Cleaning Method of Equipment Fault Database Based on ISOMAP Equidistant Mapping Clustering (2022)

With the development of artificial intelligence algorithms, monitoring data of power equipment is widely used in early fault diagnosis of equipment. Since the original monitoring data may contain some abnormal “dirty” data, which will seriously affect the accuracy of intelligent diagnosis of equipment faults, it is necessary to clean the equipment fault database. In this paper, the linear model and the proximity model are combined, and a data cleaning method based on ISOMAP(isometric feature mapping) equidistant map clustering is constructed. Firstly, the ISOMAP analysis method is used to extract the features of the original data, and on this basis, the DBSCAN(density-based spatial clustering of applications with noise) density clustering analysis is carried out. This method fully considers the nonlinear relationship and clustering characteristics between the characteristic quantities of power equipment, removes outliers, and improves data quality. This paper takes the cleaning of the fault database of the dissolved gas concentration in the oil of the transformer as an example. The results show that the fault diagnosis learning network trained by the cleaned database can improve the diagnosis accuracy by 17%. Compared with other data cleaning algorithm models, the classification and recognition rate of the method proposed in this paper is improved by 5%.
Block-STM (2023)

Block-STM is a parallel execution engine for smart contracts, built around the principles of Software Transactional Memory. Transactions are grouped in blocks, and every execution of the block must yield the same deterministic outcome. Block-STM further enforces that the outcome is consistent with executing transactions according to a preset order, leveraging this order to dynamically detect dependencies and avoid conflicts during speculative transaction execution. At the core of Block-STM is a novel, low-overhead collaborative scheduler of execution and validation tasks.
A STUDY OF LEADERSHIP STYLE, SITUATION FAVORABLENESS, AND THE RISK TAKING BEHAVIOR OF LEADERS (1978)

The purpose of this study was to investigate the risk taking behavior of school principals (the dependent variable) identified according to one of two leadership styles by Fielder's Esteem for Least Preferred Co‐worker instrument. Situation specific dilemmas were formulated for the study in a newly developed instrument which manipulated two situation specific independent variables (position power and group support). The findings support the contention that situation variables have a significant effect on the risk disposition of school leaders though no evidence was found to suggest that leader type (task oriented or relations oriented) may be determined by manifest differences in either observed risk disposition or computed risk shift.
Modification des propriétés aux interfaces d'homopolymères par des copolymères fluorés (1994)

The study of the interfacial properties of the polymer systems brought to us to synthesize anionic alive polymerization, radical polymerization model systems of polymers and fluoride copolymers. The study of the interfacial behavior required various techniques (S.I.M.S ., I.SS., XPS.).The conclusion major of our work is the highlighting of two competitive phenomena, the distribution of the copolymer fluorinated towards a polar substratum and a degradation of the chains of polymers.
THE EVALUATION OF EXPERIMENTAL PERICARDIA INFLAMMATION BY COMPUTERIZED TRANSMISSION TOMOGRAPHY (1983)

Hackney, David M.D.; Slutsky, Robert A. M.D.; Mattrey, Robert F. M.D.; Peck, Wallace W. M.D.; Higgins, Charles B. M.D. Author Information
Multimodal blending for high-accuracy instance recognition (2013)

Despite the rich information provided by sensors such as the Microsoft Kinect in the robotic perception setting, the problem of detecting object instances remains unsolved, even in the tabletop setting, where segmentation is greatly simplified. Existing object detection systems often focus on textured objects, for which local feature descriptors can be used to reliably obtain correspondences between different views of the same object. We examine the benefits of dense feature extraction and multimodal features for improving the accuracy and robustness of an instance recognition system. By combining multiple modalities and blending their scores through an ensemble-based method in order to generate our final object hypotheses, we obtain significant improvements over previously published results on two RGB-D datasets. On the Challenge dataset, our method results in only one missed detection (achieving 100% precision and 99.77% recall). On the Willow dataset, we also make significant gains on the prior state of the art (achieving 98.28% precision and 87.78% recall), resulting in an increase in F-score from 0.8092 to 0.9273.
Teil 2: Handlungsoptionen entwickeln und Entscheidungen treffen (2019)

Technologieentwicklungen frühzeitig und richtig einzuschätzen ist ausschlaggebend für den nachhaltigen Erfolg von Technologieunternehmen. Durch die weltweite Zunahme und Beschleunigung der Forschungs- und Entwicklungsaktivitäten sowie steigende Verflechtung von Wertschöpfungsketten wird dies zunehmend schwieriger. In Teil eins dieses Praxisleitfadens wurde ein Überblick über unterschiedliche Indikatoren zur Bewertung und Einstufung von Technologien geschaffen. Ziel dieses Leitfadens ist es, eine Anleitung zu geben, um mit Hilfe der Indikatoren die Entwicklungsaktivitäten technologischer Innovationen abbilden zu können. Unter Berücksichtigung unternehmensspezifischer Stärken und Schwächen, dient dies als Entscheidungshilfe zur Wahl der passenden Timing- und Technologiestrategie.
Phenolic Compounds in Foliage of Commercial Tomato Cultivars as Growth Inhibitors to the Fruitworm, Heliothis Zea1 (1982)

Abstract Semi-purifled extracts of phenolics from foliage of tomato ( Lycopersicon esculentum Mill.) inhibit larval growth of the fruitworm, Heliothis zea (Boddie), when added to artificial diets for this insect pest. The degree of inhibition of growth (dose-response) is directly related to the quantity of total phenolics in extracts added to diets, whether the extracts are of equivalent amounts of foliage from different cultivars or of foliage pooled from several cultivars added in serial dilution. Dose-responses for extracts were equal to those obtained with pure chlorogenic acid or rutin, major phenolic constituents of tomato foliage. Also, equivalent quantities of phenolics from 5 different cultivars inhibited larval growth equally when added to diets. These 3 sets of observations show that isolated tomato foliar phenolics affect H. zea larvae quantitatively, with no measurable qualitative differences between cultivars. When 2nd instar larvae were reared on excised leaflets from several cultivars of field-grown tomatoes, significant differences in larval growth between cultivars were obtained, which were consistent through two years. However, significant relationships between foliar phenolic content and larval growth were not obtained, partially because of the highly variable nature of phenolic content within and between plants. Our results suggest that phenolics in tomato foliage at the minimum contribute a substantial background level of antibiosis to H. zea.
Erythropoietin Treatment and Amino Acid Metabolism in Hemodialysis Patients (1993)

A previous report suggests that treatment with recombinant human erythropoietin (rH-EPO) significantly improves many abnormalities in circulating amino acids (AA) in hemodialysis patients. We evaluated the effects of a 12-month treatment with rH-EPO (150-250 U/kg/week) on blood AA levels in 10 patients with chronic renal failure under regular dialytic treatment. During treatment, hemoglobin levels increased from 7.0 +/- 0.3 to 10.1 +/- 0.3 g/dl at 3 months remaining steady thereafter. Before the treatment, patients showed reduced levels of essential AA (EAA), mainly valine, leucine and threonine (p < 0.05-0.01); among non-EAA (NEAA), aspartate and serine were reduced, whereas glycine, alanine, proline, citrulline and cyst(e)ine were increased (p < 0.05-0.001). Val/Gly, Ser/Gly and Tyr/Phe ratios were low (p < 0.05-0.01). Total EAA and total NEAA (619 +/- 21 and 1,382 +/- 75 mumol/l, respectively, before the study) were unchanged (639 +/- 22 and 1,410 +/- 89 mumol/l, respectively) at 12 months. Abnormalities in AA levels observed before the treatment persisted throughout the study. Only serine increased at the end of the study (p < 0.05). In conclusion, contrary to what has been reported, treatment with rH-EPO is not associated with an amelioration of AA metabolism in hemodialysis patients.
Assessment of Authentic Performance in School Mathematics (2013)

Este item é uma cópia digitalizada do livro do “Assessment of Authentic Performance in School Mathematics”, publicado em 1994 por “Division of the american association for the advancementy of Science”. Contendo 445 páginas sem a capa
Long non-coding RNA ZFAS1 interacts with CDK1 and is involved in p53-dependent cell cycle control and apoptosis in colorectal cancer (2015)

We determined expression of 83 long non-coding RNAs (lncRNAs) and identified ZFAS1 to be significantly up-regulated in colorectal cancer (CRC) tissue. In cohort of 119 CRC patients we observed that 111 cases displayed at least two-times higher expression of ZFAS1 in CRC compared to paired normal colorectal tissue (P < 0.0001). By use of CRC cell lines (HCT116+/+, HCT116-/- and DLD-1) we showed, that ZFAS1 silencing decreases proliferation through G1-arrest of cell cycle, and also tumorigenicity of CRC cells. We identified Cyclin-dependent kinase 1 (CDK1) as interacting partner of ZFAS1 by pull-down experiment and RNA immunoprecipitation. Further, we have predicted by bioinformatics approach ZFAS1 to sponge miR-590-3p, which was proved to target CDK1. Levels of CDK1 were not affected by ZFAS1 silencing, but cyclin B1 was decreased in both cell lines. We observed significant increase in p53 levels and PARP cleavage in CRC cell lines after ZFAS1 silencing indicating increase in apoptosis. Our data suggest that ZFAS1 may function as oncogene in CRC by two main actions: (i) via destabilization of p53 and through (ii) interaction with CDK1/cyclin B1 complex leading to cell cycle progression and inhibition of apoptosis. However, molecular mechanisms behind these interactions have to be further clarified.
Hash-Grams (2018)

N-grams have long been used as features for classification problems, and their distribution often allows selection of the top-k occurring n-grams as a reliable first-pass to feature selection. However, this top-k selection can be a performance bottleneck, especially when dealing with massive item sets and corpora. In this work we introduce Hash-Grams, an approach to perform top-k feature mining for classification problems. We show that the Hash-Gram approach can be up to three orders of magnitude faster than exact top-k selection algorithms. Using a malware corpus of over 2 TB in size, we show how Hash-Grams retain comparable classification accuracy, while dramatically reducing computational requirements.
Curcumin Decreases Binding of Shiga-Like Toxin-1B on Human Intestinal Epithelial Cell Line HT29 Stimulated with TNF-.ALPHA. and IL-1.BETA.: Suppression of p38, JNK and NF-.KAPPA.B p65 as Potential Targets (2006)

Intestinal epithelial cells (IECs) have been known to produce galactose-alpha1,4-galactose-beta1,4-glucose ceramide (Gb3) which plays a pivotal role in the mucosal immune response. In particular, Shiga-like toxins (Stx) can induce apoptosis of IECs in the development of hemolytic uremic syndrome (HUS) through binding on Gb3. Therefore, it has been hypothesized that down-regulation of Gb3 (or binding of Stx) prevents Stx from damaging in IECs. This study investigated whether curcumin, having various biological properties such as being anti-bacterial, anti-viral and anti-cancer, could decrease binding of Stx and the related signal pathway. Curcumin significantly inhibited the binding of Stx and the production of Gb3 synthase (GalT6) mRNA in HT29 IECs stimulated with TNF-alpha and IL-1beta. Additionally, curcumin was able to inhibit mitogen-activated protein kinases (MAPKs), such as p38 and JNK, but not ERK1/2, degradation of IkappaB or translocation of NF-kappaB p65. Furthermore, curcumin significantly attenuated Stx-1 induced cell death and IL-8 expression. In summary, these data link Gb3 expression in HT29 cells stimulated with TNF-alpha and IL-1beta and suggest that blocking of Stx-binding by curcumin may prevent the Stx-associated HUS.
Physical, Social, and Experiential Knowledge in Pervasive Computing Environments (2007)

Pervasive computing designers and researchers often create services and applications to help people record their experiences. At the same time, cheap, small, and easy-to-deploy recording technologies are quickly emerging throughout public spaces. In many ways, these technologies are pervasive computing realized. Understanding how people deal with audio and video recording is therefore a good way to explore how people might adopt, adapt, and react to pervasive computing technologies in general. A long-term deployment of a system for recording experiences in informal spaces demonstrates that people use physical, social, and experiential knowledge to determine new technologies' relative utility and safety. In this paper, we aim to add significantly to the research surrounding security and privacy concerns by focusing on them rather than just noting them as a side effect of testing an application's utility and usability.
Potential dental effects of infants' fruit drinks studied in vitro (1990)

Eighteen different infants' drinks from five manufacturers were examined for their carbohydrate, calcium, phosphorus and acid contents, and their attack on tooth mineral. Seven of the drinks were compared with nine varieties of adults' soft drinks, and demineralization was studied with and without the presence of a cariogenic oral streptococcus. The influence of the acids already in the drinks in dissolving Ca and P outstripped that of any acid generated in these studies in vitro by microbial fermentation of the sugars they contained, giving an indication of their relative erosiveness rather than their cariogenic action. Various other features of the drinks relevant to dental health were identified. Titratable acid was a better guide than pH to their dental properties. Although there were considerable differences between the various infants' drinks, taken as a group, their acidity levels and demineralizing powers were generally lower than those of the adults' drinks.
Lipid droplet-associated kinase STK25 regulates peroxisomal activity and metabolic stress response in steatotic liver (2019)

Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are emerging as leading causes of liver disease worldwide and have been recognized as one of the major unmet medical needs of the 21st century. Our recent translational studies in mouse models, human cell lines, and well-characterized patient cohorts have identified serine/threonine kinase (STK)25 as a protein that coats intrahepatocellular lipid droplets (LDs) and critically regulates liver lipid homeostasis and progression of NAFLD/NASH. Here, we studied the mechanism-of-action of STK25 in steatotic liver by relative quantification of the hepatic LD-associated phosphoproteome from high-fat diet-fed <i>Stk25</i> knockout mice compared with their wild-type littermates. We observed a total of 131 proteins and 60 phosphoproteins that were differentially represented in STK25-deficient livers. Most notably, a number of proteins involved in peroxisomal function, ubiquitination-mediated proteolysis, and antioxidant defense were coordinately regulated in <i>Stk25</i><sup>-/-</sup> versus wild-type livers. We confirmed attenuated peroxisomal biogenesis and protection against oxidative and ER stress in STK25-deficient human liver cells, demonstrating the hepatocyte-autonomous manner of STK25's action. In summary, our results suggest that regulation of peroxisomal function and metabolic stress response may be important molecular mechanisms by which STK25 controls the development and progression of NAFLD/NASH.
Alveolar oxygen partial pressure and O2 depletion rate mapping in rats using 3He ventilation imaging (2007)

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Expression of Pejerrey Gonadotropin-Releasing Hormone in Three Orders of Fish1 (2002)

Molecular variants of GnRH were characterized by reverse-phase, high-performance liquid chromatography from brain extracts of fish in three different orders: Synbranchiformes (swamp eel [Synbranchus marmoratus]), Cyprinidontiformes (platyfish [Xiphophorus maculatus] and green swordtail [X. helleri]), and Atheriniformes (Patagonia pejerrey [Odontesthes hatchery]). Also, pituitary gland extracts from the pejerrey O. bonariensis (Atheriniformes) were characterized. Eluted fractions were tested in radioimmunoassays with antisera specific to GnRH, including both antisera that detected only one form of GnRH and those that detected several forms. The results show that brain extracts obtained from all species contained the same three molecular forms of GnRH, which were immunologically and chromatographically undistinguishable from chicken GnRH-II, pejerrey GnRH (pjGnRH), and salmon GnRH. This study supports the hypothesis that expression of these three forms is common in different fish orders and that pjGnRH is the main regulator of pituitary function in these fish.