gebhart/patrepeval huggingface dataset:
HPV16 RNA-LPX vaccine mediates complete regression of aggressively growing HPV-positive mouse tumors and establishes protective T cell memory (2019)

HPV16 infections are associated with a variety of cancers and there is compelling evidence that the transforming activity of HPV16 critically depends on the expression of the viral oncoproteins E6 and E7. Therapeutic cancer vaccines capable of generating durable and specific immunity against these HPV16 antigens hold great promise to achieve long-term disease control. Here we show in mice that HPV16 E7 RNA-LPX, an intravenously administered cancer vaccine based on immuno-pharmacologically optimized antigen-encoding mRNA, efficiently primes and expands antigen-specific effector and memory CD8<sup>+</sup> T cells. HPV-positive TC-1 and C3 tumors of immunized mice are heavily infiltrated with activated immune cells and HPV16-specific T cells and are polarized towards a proinflammatory, cytotoxic and less immune-suppressive contexture. E7 RNA-LPX immunization mediates complete and durable remission of progressing tumors. Circulating memory T cells are highly cytotoxic and protect from tumor rechallenge. Moreover, E7 RNA-LPX immunization sensitizes anti-PD-L1 refractory tumors to checkpoint blockade. In conclusion, our data highlight the potential of HPV16 RNA-LPX for the treatment of HPV-driven cancers.
The sound quality of vehicle interior noise: a challenge for the NVH-engineers (2004)

Learning analytics is a significant area of technology-enhanced learning that has emerged during the last decade. This review of the field begins with an examination of the technological, educational and political factors that have driven the development of analytics in educational settings. It goes on to chart the emergence of learning analytics, including their origins in the 20th century, the development of data-driven analytics, the rise of learning-focused perspectives and the influence of national economic concerns. It next focuses on the relationships between learning analytics, educational data mining and academic analytics. Finally, it examines developing areas of learning analytics research, and identifies a series of future challenges.
Accenture technology labs (2008)

This paper describes the high level goals of Accenture Technology Labs' research group, and concentrates specifically on the HCI research domain. We discuss three representative projects in order to give the reader a sense of our research agenda, as well as the culture of the group itself.
Crystal Structure of Photolyase (Photoreactivating Enzyme) and Its Cofactor Recognition. (1998)

The crystal structure of 8-HDF type photolyase from Anacystis nidulans showed the similarity of the backbone structure with MTHF type E. coli photolyase but completely different binding site of the light-harvesting cofactor. This is a first example that homologous primary and tertiary structures in closely related proteins recognize two different types of cofactors at different binding-sites. The structure and function of photolyase and its cofactor recoginition are reviewed and discussed.
A completely precious metal–free alkaline fuel cell with enhanced performance using a carbon-coated nickel anode (2022)

SignificanceWe present a groundbreaking advance in completely nonprecious hydrogen fuel cell technologies achieving a record power density of 200 mW/cm<sup>2</sup> with Ni@CN<sub>x</sub> anode and Co-Mn cathode. The 2-nm CN<sub>x</sub> coating weakens the O-binding energy, which effectively mitigates the undesirable surface oxidation during hydrogen oxidation reaction (HOR) polarization, leading to a stable fuel cell operation for Ni@CN<sub>x</sub> over 100 h at 200 mA/cm<sup>2</sup>, superior to a Ni nanoparticle counterpart. Ni@CNx exhibited a dramatically enhanced tolerance to CO relative to Pt/C, enabling the use of hydrogen gas with trace amounts of CO, critical for practical applications. The complete removal of precious metals in fuel cells lowers the catalyst cost to virtually negligible levels and marks a milestone for practical alkaline fuel cells.
GW170817: Implications for the Stochastic Gravitational-Wave Background from Compact Binary Coalescences (2017)

The LIGO Scientific and Virgo Collaborations have announced the first detection of gravitational waves from the coalescence of two neutron stars. The merger rate of binary neutron stars estimated from this event suggests that distant, unresolvable binary neutron stars create a significant astrophysical stochastic gravitational-wave background. The binary neutron star background will add to the background from binary black holes, increasing the amplitude of the total astrophysical background relative to previous expectations. In the Advanced LIGO-Virgo frequency band most sensitive to stochastic backgrounds (near 25 Hz), we predict a total astrophysical background with amplitude ΩGW(f=25Hz)=1.8+2.7−1.3×10−9 with 90% confidence, compared with ΩGW(f=25Hz)=1.1+1.2−0.7×10−9 from binary black holes alone. Assuming the most probable rate for compact binary mergers, we find that the total background may be detectable with a signal-to-noise-ratio of 3 after 40 months of total observation time, based on the expected timeline for Advanced LIGO and Virgo to reach their design sensitivity.
Understanding interdisciplinary health sciences collaborations: a campus-wide survey of obesity experts. (2008)

This paper reports a campus-wide survey of obesity experts that allowed us to understand organizational factors and collaboration patterns affiliated with health sciences research. By combining Google and PubMed searches and the snowball sampling method, we identified and then surveyed 113 obesity experts on their collaborators, research interests, and affiliations with academic departments and research centers. The response rate was 61%. We describe the diversity in organizational affiliations, research interests, journals for disseminating results, and collaboration patterns among the respondents. We also analyze the challenges and research opportunities related to identifying experts and forging interdisciplinary health sciences collaborations. We conclude with possible success factors for sustained interdisciplinary collaborations.
Sensory processing in autism spectrum disorder (2020)

Autism spectrum disorders (ASDs) are a group of complex, heterogeneous, and pervasive neurodevelopmental disorders, characterized by diverse manifestations including impairment in social abilities, decreased or disordered verbal communications, and restricted or repetitive behaviors.1 Abnormalities in sensory perception and processing have long been recognized in up to 90% of individuals diagnosed with ASD.2 These observations have been ascribed to alterations in central sensory processing, especially in the multimodal integration of sensory information.3 However, given the pervasiveness of ASD, the possibility of peripheral sensory nervous system (PNSs) dysfunction should be considered as well. Evidence of enteric nervous system as well as auditory changes4,5 has raised this intriguing possibility.
Lift and drag forces on an inclined plow moving over a granular surface (2011)

We studied the drag and lift forces acting on an inclined plate while it is dragged on the surface of a granular media, both in experiment and in numerical simulation. In particular, we investigated the influence of the horizontal velocity of the plate and its angle of attack. We show that a steady wedge of grains is moved in front of the plow and that the lift and drag forces are proportional to the weight of this wedge. These constants of proportionality vary with the angle of attack but not (or only weakly) on the velocity. We found a universal effective friction law that accounts for the dependence on all the above-mentioned parameters. The stress and velocity fields are calculated from the numerical simulations and show the existence of a shear band under the wedge and that the pressure is nonhydrostatic. The strongest gradients in stress and shear occur at the base of the plow where the dissipation rate is therefore highest.
Taking lipospermines and polyethylenimine from in vitro to in vivo (1998)

International audience
UV-B-Therapie von Hautkrankheiten: ein Update zu Indikationen, Wirksamkeit, Nebenwirkungen und Durchführung (2018)

Zusammenfassung Seit Anfang des 20. Jahrhunderts ist die UV-B-Phototherapie eine der tragenden Säulen der vielfältigen dermatologischen Therapiestrategien, die ständig weiterentwickelt wurden. Diese Weiterentwicklungen betrafen sowohl die Strahlenquellen mit effektiveren Aktionsspektren (Schmalspektrum UV-B) als auch Studien zu verschiedenen Kombinationsschemata mit externen und systemischen Pharmaka. Die Psoriasis stellt nach wie vor die Hauptindikation für eine UV-B-Therapie dar. Im Laufe der Jahre hat sich das Indikationsspektrum deutlich erweitert. Akute Nebenwirkungen sind Sonnenbrände durch falsche Dosierungen, wichtiger sind potenzielle chronische Nebenwirkungen wie die chronische aktinische Hautschädigung, inklusive der Photokarzinogenese. Die praktische Durchführung erfordert Erfahrung, auch wenn sie in Leitlinien sehr umfassend widergegeben ist.
Extensive Studies on π-Stacking of Poly(3-alkylthiophene-2,5-diyl)s and Poly(4-alkylthiazole-2,5-diyl)s by Optical Spectroscopy, NMR Analysis, Light Scattering Analysis, and X-ray Crystallography (1998)

Stacking of poly(3-alkylthiophene)s P3RThs and poly(4-alkylthiazole)s P4RTzs has been studied. Light scattering analysis indicates that head-to-tail (HT) type HT-P3HexTh (R = n-C6H13) gives a degree of depolarization (ρv) of 0.26 in CHCl3, which reveals that HT-P3HexTh takes a stiff structure even in the good solvent. Addition of CH3OH to CHCl3 solutions of HT-P3HexTh and head-to-head (HH) type HH-P4HepTz (R = n-C7H15) leads to π-stacking of the polymer molecules to form stable colloidal particles. The light scattering analysis of the colloidal solution of HT-P3HexTh in a 2:1 solution of CHCl3 and CH3OH reveals that HT-P3HexTh is aggregated in a parallel style. Results of filtration experiments using membranes with 0.20 and 0.02 μm pores agree with the degree of the aggregation. P3HexThs with irregular structures (P3HexTh (Fe) and P3HexTh (Ni) with HT/HH ratios of about 7/3 and 1/2, respectively) show a weaker trend to aggregate; however, P3HexTh (Fe) is considered to stack in a surface region of a stretched poly(ethylene terephthalate) PET film. A dichroism observed with the stretched PET film indicates that the π−π* absorption as well as photoluminescence of the stacked P3HexTh molecules have a transition moment along the direction of the polymer main chain. X-ray diffraction analysis of HT-P3RThs and HH-P4RTzs reveals that they take a face-to-face stacked structure with an end-to-end packing mode, except for HT-P3MeTh (R = Me). HT-P3MeTh forms a face-centered lattice with an interlayer distance of 3.51 Å. An alternative copolymer of bithiazole and 4,4‘-dibutylbithiazole is packed in an interdigitation mode. At temperatures below 0 °C, the HT-P3HexTh molecules are π-stacked in CHCl3, and the 1H NMR spectrum shows a severe magnetic effect on the thiophene ring. Solid 13C NMR data are also consistent with the π-stacking.
Symmetrizations for clustering directed graphs (2011)

Graph clustering has generally concerned itself with clustering undirected graphs; however the graphs from a number of important domains are essentially directed, e.g. networks of web pages, research papers and Twitter users. This paper investigates various ways of symmetrizing a directed graph into an undirected graph so that previous work on clustering undirected graphs may subsequently be leveraged. Recent work on clustering directed graphs has looked at generalizing objective functions such as conductance to directed graphs and minimizing such objective functions using spectral methods. We show that more meaningful clusters (as measured by an external ground truth criterion) can be obtained by symmetrizing the graph using measures that capture in- and out-link similarity, such as bibliographic coupling and co-citation strength. However, direct application of these similarity measures to modern large-scale power-law networks is problematic because of the presence of hub nodes, which become connected to the vast majority of the network in the transformed undirected graph. We carefully analyze this problem and propose a Degree-discounted similarity measure which is much more suitable for large-scale networks. We show extensive empirical validation.
Identification of parameters relevant for the quantification of intracellular metabolites in mammalian cell culture (2004)

The analysis of metabolites is an important prerequisite for the optimization of many biotechnological processes, especially in animal cell culture. Apart from monitoring the parameters pH, temperature, oxygen, and carbon dioxide, the medium composition is analyzed in most cases and concentrations of substrates like glucose and glutamine as well as product and other metabolites like lactate and ammonia are measured. However, to get further insights into the metabolic network, it is essential to determine intracellular intermediates of different pathways. In this work, an adherent MDCK cell line, used for the production of influenza vaccine, is examined for intracellular intermediates of the energy metabolism, especially glycolysis and citric acid cycle. This cell line is usually cultivated in batch mode and after a growth period of about one week, cells are infected with virus. Clear differences in the metabolite profiles are expected before and after infection, but also with regard to media composition, e.g. with and without serum. However, in advance to these measurements, a suitable procedure for quenching and extraction has to be identified to assure an acceptable accuracy of the method. In this presentation, first results of our experimental approach are shown. Quantative measurements are performed on two different anion exchange chromatography systems. One system (DX-320, Dionex, Idstein, Germany) is designed for the separation of inorganic ions, organic acids, and energy phosphates using conductivity and UV for detection. The other system (DX-600, Dionex) is suitable for the analysis of sugars and sugar phosphates using a Pulsed Amperometric Detector (PAD). In standard runs, a wide range of intracellular metabolites could be separated and quantified even in concentrations below the micromolar range. However, different chemical and physical properties of the intermediates to measure, as well as the subsecond in-vivo enzyme kinetics for some reactions complicate the finding of a single quenching, washing, and extraction procedure for both chromatography systems. Various strategies and methods are under systematic investigation. After the elucidation of important parameters influencing metabolite pools during extraction, further work will include the validation of the quantification method and identification of not yet revealed peaks. Moreover, variations in metabolite composition in different physiological states e.g. during growth, before and after virus infection, medium depletion, will be investigated.
Spin-Dependent Transport in Fe/GaAs(100)/Fe Vertical Spin-Valves (2016)

The integration of magnetic materials with semiconductors will lead to the development of the next spintronics devices such as spin field effect transistor (SFET), which is capable of both data storage and processing. While the fabrication and transport studies of lateral SFET have attracted greatly attentions, there are only few studies of vertical devices, which may offer the opportunity for the future three-dimensional integration. Here, we provide evidence of two-terminal electrical spin injection and detection in Fe/GaAs/Fe vertical spin-valves (SVs) with the GaAs layer of 50 nanometers thick and top and bottom Fe electrodes deposited by molecular beam epitaxy. The spin-valve effect, which corresponds to the individual switching of the top and bottom Fe layers, is bias dependent and observed up to 20 K. We propose that the strongly bias- and temperature-dependent MR is associated with spin transport at the interfacial Fe/GaAs Schottky contacts and in the GaAs membranes, where balance between the barrier profiles as well as the dwell time to spin lifetime ratio are crucial factors for determining the device operations. The demonstration of the fabrication and spin injection in the vertical SV with a semiconductor interlayer is expected to open a new avenue in exploring the SFET.
An intraluminal transducer/telemetry system for oviductal motility studies (1976)

A method for measurement of changes in lumen diameter of the oviduct has been developed. Miniature intraluminal "doughnut-shaped" transducers, 1.0-1.2 mm in diameter, constructed from conductive silicone rubber are implanted in the rabbit isthmus and respond to localized changes--increases or decreases--in lumen diameter. Multiple transducer implants in the same tube permit rate as well as direction of contractions to be determined. A custom-designed, micropower dual-channel telemetry system was fabricated to record motility from unrestrained animals. Typical data collected using this system to determine the effects of induced ovulation on instantaneous changes in lumen diameter are presented.
ReCPE: A PE for Reconfigurable Lightweight Cryptography (2021)

The Internet-of-Things has given rise to an over-whelming number of resource-constrained devices which must communicate securely with a core server. Due to the variability in processing power among these devices, one lightweight crypto-graphic (LWC) algorithm cannot be standardized. This creates a problem for fog and cloud architectures, where a central server, is subsequently required to support many ciphers. Compounding this problem, LWC ciphers tend to require large numbers of rounds to achieve high security levels, thus occupying the server for unacceptable lengths of time. To minimize LWC overhead, we propose a novel parallel mapping of LWC ciphers and ReCPE, a reconfigurable, lightweight processing element (PE) for use in hardware security modules (HSM) and array processors such as smartNICs. The proposed design was synthesized for both FPGA and ASIC implementations. We validate the ReCPE architecture by comparing it with a baseline array processor and custom field programmable gate array (FPGA) LWC accelerators that use dynamic reconfiguration. The ReCPE architecture is shown to accelerate cryptographic processing by 2× when compared to a baseline PE, with 30% and 60% increases in logic and registers, respectively. Furthermore, we achieve a 50× improvement in dynamic reconfiguration environments when compared to custom FPGA accelerators.
DoesGleichenia polypodioides(Kystervaring) Influence the Growth of Pines? (1981)

SYNOPSIS The influence of a Gleichenia polypodioides understorey cover on the growth of pines in the Southern Cape was tested in two replicated trials incorporating two treatments, i.e. (a) removal of the fern by slashing and (b) fern left undisturbed. Observations over 20 years showed that there were no significant growth differences between the two treatments at either trial.
A Simple and Generalized Space Vector PWM Control of Cascaded H-Bridge Multilevel Inverters (2006)

This paper presents an automatic switching pattern generation for multilevel cascaded H-bridge inverters with equal dc voltage sources, based on the space-vector pulse width modulation (SVPWM) techniques. The proposed switching strategy generates a voltage vector with very low harmonic distortion and reduced switching frequency. This new control method is an attractive alternative to the classic multilevel pulse width modulation techniques considering the following aspects, mainly, minimization of voltage and current total harmonic distortion (THD), extension of range of linear operation; and least number of commutations. To solve the problem of computational complexity in multilevel inverters due to the large number of space vectors and redundant switching states, a simple and general space vector PWM algorithm is proposed. Based on this algorithm, the location of the reference voltage vector can be easily determined and the calculation of dwell times becomes very simple. It is also mentioned that this method requires lower memory spaces as there is no need of any look-up table. To verify the algorithms, a seven-level cascaded H-bridge inverter drive system was constructed and simulation results are present here.
Echocardiographic Evaluation of Different LAA Closure Techniques during Concomitant Surgical AF Ablation (2021)

Objectives: Left atrial appendage (LAA) closure is a routine part of AF ablation surgery. Different LAA closure techniques are used in cardiac surgery with various results. We therefore evaluated efficacy of four different LAA closure methods in patients after concomitant surgical AF ablation using transesophageal echocardiography.
Set-membership state estimation by solving data association (2020)

This paper deals with the localization problem of a robot in an environment made of indistinguishable landmarks, and assuming the initial position of the vehicle is unknown. This scenario is typically encountered in underwater applications for which landmarks such as rocks all look alike. Furthermore, the position of the robot may be lost during a diving phase, which obliges us to consider unknown initial position. We propose a deterministic approach to solve simultaneously the problems of data association and state estimation, without combinatorial explosion. The efficiency of the method is shown on an actual experiment involving an underwater robot and sonar data.
Rac1 contributes to trastuzumab resistance of breast cancer cells: Rac1 as a potential therapeutic target for the treatment of trastuzumab-resistant breast cancer (2009)

Although treatment with trastuzumab improves outcomes for women with ErbB2-positive breast cancer, many patients who achieve an initial response to trastuzumab subsequently acquire resistance within 1 year. Rac1, a Ras-like small GTPase, has been implicated in the control of cell growth and morphology and is believed to be associated with breast cancer progression and metastasis. Here, we show that when parental SKBR3 cells become resistant to trastuzumab, Rac1 activity is increased, leading to altered cell morphology, which is accompanied by significant cytoskeleton disorganization. Furthermore, both trastuzumab-mediated down-regulation of ErbB2 and epidermal growth factor-induced down-regulation of epidermal growth factor receptor are impaired in the trastuzumab-resistant SKBR3 cells, indicating that the endocytic down-regulation of ErbB receptors is compromised in the resistant cells. This results in an aberrant accumulation of ErbB2 on the cell surface and enhanced ErbB2 and extracellular signal-regulated kinase activity in trastuzumab-resistant SKBR3 cells. Additionally, overexpression of constitutively active Rac1G12V in parental SKBR3 cells reduces sensitivity to trastuzumab. After reduction of Rac1 activity by NSC23766, a specific Rac1 inhibitor, trastuzumab-resistant SKBR3 cells display a cellular morphology similar to parental SKBR3 cells. Moreover, we show that NSC23766 restores trastuzumab-mediated endocytic down-regulation of ErbB2 and reduces extracellular signal-regulated kinase activity in resistant SKBR3 cells. Our findings highlight an important role for Rac1 in trastuzumab resistance of human breast cancer cells and identify the impaired trastuzumab-mediated endocytic down-regulation of ErbB2 as a novel mechanism of trastuzumab resistance. The significant effects of NSC23766 on trastuzumab-resistant SKBR3 cells warrant further study of NSC23766 as a potential treatment of trastuzumab-resistant breast cancers.
Infradiaphragmatic Central Venous Pressures Reflect Supradiaphragmatic Pressures in Stable Burn Patients (1999)

In the absence of clinically significant abdominal distention, infradiaphragmatic central venous pressure is an accurate reflection of supradiaphragmatic pressure, and indirectly, circulating blood volume.