gebhart/patrepeval huggingface dataset:
The role of the hepatitis C virus glycoproteins in infection (2000)

HCV encodes two glycoproteins, E1 and E2, that are believed to be exposed on the surface of virions. These molecules are likely to be involved in viral interactions with the host immune response and responsible for mediating viral entry into target cells. They are obvious major components for prototype vaccine studies. Recently, E2 has been reported to bind to the tetraspan molecule CD81, which represents a putative receptor for HCV. Here, we discuss the role the HCV gps may play during infection, the contribution of E2 gp variation to HCV evasion from the immune response and possible implications of the E2-CD81 interaction for HCV pathogenesis.
New developments in photochromic polymers (1975)

Abstract New developments on photochromic polymers have been obtained with systems containing spirobenzopyran derivatives. The importance of the chemical incorporation of the photochrome within the polymer backbone is stressed, and the influence of matrix orientation on the rate of fading is shown. Well known fatigue phenomena are illustrated on the basis of the changes of photostationary optical density on repeating the irradiation–dark recovery cycle. The photomechanical properties and characteristics of rubbery polyethylacrylates crosslinked with the photochrome bismethacrylate are considered in detail. Another principle of photochromism based on photodissociation phenomena is also discussed in the case of the photodissociation and photorecombination of anthracene derivatives and benzacridizinium tosylate, as well as in the case of the photodissociation and thermal recombination of benzpinacol groups incorporated in the polymer main chain. In these experiments in the solid state, it can be shown that the recombination involves always two successive steps: a rapid step corresponding to cage recombination and a second slow step related to diffusion and segment mobility ( T g ) of the polymer.
INCREASED SERUM ACETATE AS A MARKER OF PROBLEM DRINKING AMONG DRUNKEN DRIVERS (1988)

727 consecutive drunken drivers were studied for laboratory markers of excessive alcohol consumption. Serum gamma-glutamyltransferase and alanine aminotransferase showed no differences and aspartate aminotransferase and blood alcohol concentration only small differences between groups of first and repeating drunk driving offenders. The best laboratory test to differentiate the repeating offenders with probably more serious alcohol problems from the first offenders was in our material serum acetate, the mean serum acetate level of the repeating offenders being highly significantly (P less than 0.001) higher than that of the first offenders or nonalcoholic controls. Serum acetate also differentiated first offenders from nonalcoholic controls (P less than 0.001). Our results suggest that serum acetate could be used for the screening of problem drinking among drunken drivers.
Oblique back illumination cell phone microscopy for blood analysis (Conference Presentation) (2023)

The complete blood count (CBC) is a foundational diagnostic test, but its accessibility is limited due to the blood draw, expensive laboratory equipment, and trained personnel required. Here, we present a cell phone microscope design for achieving phase contrast in high resolution capillary imaging, which allows individual blood cells to be imaged for a non-invasive CBC. The cell phone microscope uses a reversed lens as an objective to maintain a high resolution. Relay lenses create space for incorporation of an offset LED that can be critically imaged to produce oblique back illumination, resulting in phase contrast.
Associations of Aortic Distensibility and Arterial Elasticity With Long-Term Visit-to-Visit Blood Pressure Variability: The Multi-Ethnic Study of Atherosclerosis (MESA) (2013)

In this multiethnic cohort, functional alterations of central and peripheral arteries were associated with greater long-term VVV of SBP.
Synthesis and Sintering of Zirconia Nano-Powder by Non-Isothermal Decomposition from Hydroxide. (2001)

A non-conventional route for controlling both the particle size distribution and the morphology of yttriastabilized tetragonal zirconia has been studied. Non-isothermal decomposition from hydroxide was chosen as a process suitable for preparing the uniformly aggregated nano-crystalline 3Y-TZP powder. The obtained powder had a particle size of 9-18nm, and a narrow aggregate size distribution of 20-70nm. The characteristics of zirconia non-isothermal calcination were investigated in order to choose the best heating regime. Changes in the heating schedule caused changes in the powder morphology. Calcination includes several processes: complete decomposition of hydroxides, crystallization of zirconia, close packing into aggregates, and agglomeration at elevated temperatures because of particle bridging. These processes are superimposed with elevating the calcination temperature. There are two schedules differing both in fineness of the final powder and degree of aggregation-agglomeration. A non-linear heating schedule, produced the finest powder, uniformly aggregated, and non-agglomerated. Keeping lowest possible temperature allowed preventing high-temperature bonding and bridging of particles, which results in hard agglomerates. A high packing density of 56% was achieved after slip casting and cold isostatic pressing, which allowed low-temperature sintering, resulting in a fine-grained dense ceramic body.
Renormalisation group calculations for two dimensional disordered Ising models (1977)

The Niemeijer-van Leeuwen formulation of the renormalisation group has been used to discuss the quenched dilute Ising model and the Ising spin-glass in two dimensions. The authors chose a five-spin cell which, in the pure case, treats the Ising antiferromagnet equally as well as the ferromagnet. This choice of cell leads to the existence of a spin-glass ground state which was found to be stable for the whole composition range. The spin-glass transition was found to be sharp and the corresponding critical exponents were calculated. For the dilute Ising model the behaviour of the reduced critical temperature Tc(p)/Tc(1), the percolation concentration and the correlation length exponent were found to be in good agreement with the exact results and series calculations.
Radar HRRP target recognition based on linear dynamic model (2011)

A novel recognition method is proposed to relax the heavy requirement of training set size in the radar High Resolution Range Profile (HRRP) target recognition. Firstly, the statistical characteristic of HRRP's frequency spectrum is analyzed and considered to be a wide-sense stationary process. Then a linear dynamic model is introduced to describe the frequency spectrum amplitude and an Expectation Maximization (EM) algorithm is employed to estimate model parameters. Finally, experimental results show the proposed method can obtain satisfactory recognition accuracy and rejection performance with only a few training samples.
Tunable, luminescent, and self-healing hybrid hydrogels of polyoxometalates and triblock copolymers based on electrostatic assembly (2013)

Hybrid hydrogels based on electrostatic co-assembly of polyoxometalates and ABA triblock copolymers were readily prepared and exhibit excellent luminescence and self-healing performance.
Liquid-phase hydrogenation with nickel supported on modified alumina-aluminum phosphate (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLiquid-phase hydrogenation with nickel supported on modified alumina-aluminum phosphateGeorge Marcelin, Roger F. Vogel, and Harold E. SwiftCite this: Ind. Eng. Chem. Prod. Res. Dev. 1984, 23, 1, 41–44Publication Date (Print):March 1, 1984Publication History Published online1 May 2002Published inissue 1 March 1984https://pubs.acs.org/doi/10.1021/i300013a008https://doi.org/10.1021/i300013a008research-articleACS PublicationsRequest reuse permissionsArticle Views126Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
The Rhizobium meliloti groELc locus is required for regulation of early nod genes by the transcription activator NodD. (1995)

The molecular chaperones related to GroEL (hsp60, cpn60) interact with partially folded proteins and appear to assist them to attain active and correctly folded conformation. They are required for cell viability but are probably more important for some processes than for others. Through a random genetic search to find loci that are required for expression of the Rhizobium meliloti nod (nodulation) genes, we isolated a mutant (B4) defective in luteolin-dependent activation of nod gene expression, and found it carries a Tn5 insertion within a chromosomal groEL gene (groELc) located just downstream of a groESc gene. The groELc mutation affected activity of three related LysR-type activator proteins NodD1, NodD3, and SyrM; on plants, the mutants formed nodules late, and the nodules were Fix-. Hybridization and protein expression analysis show that a similar groESL locus (groESLa) maps to the Rm1021 megaplasmid pSyma. Southern blot analysis revealed additional, but less closely related sequences hybridizing to groELc and groESc probes elsewhere in the R. meliloti genome. Clones of groESLc and groESLa can each restore robust phage lambda growth on an Escherichia coli groE mutant. Likewise each clone can complement all of the phenotypes observed for B4 mutants; thus, the two appear to be functionally equivalent if expression is controlled. We determined that groELc is required for normal DNA binding of the NodD target sequence in R. meliloti. GroEL coimmunopurifies with NodD1 from R. meliloti, which suggests a direct physical association between these proteins. GroEL is thus probably involved in the folding or assembly of transcriptionally active NodD.
Measuring the Overall Volumetric Heat Transfer Coefficient in a Vapor-Liquid–Liquid Three-Phase Direct Contact Heat Exchanger (2017)

An experimental investigation of the volumetric heat transfer coefficient in a three-phase direct contact condenser was carried out. A 75-cm-long cylindrical Perspex column with a 4 cm diameter was used. Only 48 cm of the column was utilised as the active direct contact condensation height. Pentane vapor at three different initial temperatures (40°C, 43.5°C, and 47.5°C), with differing mass flow rates, and tap water at a constant initial temperature (19°C) with five different mass flow rates were employed as the dispersed phase and the continuous phases, respectively. The results showed that the volumetric heat transfer coefficient increased with increasing mass flow rate ratio (variable dispersed phase mass flow rate per constant continuous phase mass flow rate), the continuous phase mass flow rate and holdup ratio. An optimal value of the continuous phase mass flow rate is shown for an individual dispersed phase mass flow rates. This value increases with increasing vapor (dispersed) phase mass flow rate. Furthermore, it was observed that the initial driving temperature difference had no effect on the volumetric heat transfer coefficient. While, the temperature gained by the continuous phase has a considerable effect.
Faculty Opinions recommendation of Association of sleep duration and quality with subclinical atherosclerosis. (2019)

BACKGROUND: Sleep duration and quality have been associated with increased cardiovascular risk. However, large studies linking objectively measured sleep and subclinical atherosclerosis assessed in multiple vascular sites are lacking.OBJECTIVES: The purpose of this study was to evaluate the association of actigraphy-measured sleep parameters with subclinical atherosclerosis in an asymptomatic middle-aged population, and investigate interactions among sleep, conventional risk factors, psychosocial factors, dietary habits, and inflammation.METHODS: Seven-day actigraphic recording was performed in 3,974 participants (age 45.8 ± 4.3 years; 62.6% men) from the PESA (Progression of Early Subclinical Atherosclerosis) study. Four groups were defined: very short sleep duration < 6 h, short sleep duration 6 to 7 h, reference sleep duration 7 to 8 h, and long sleep duration >8 h. Sleep fragmentation index was defined as the sum of the movement index and fragmentation index. Carotid and femoral 3-dimensional vascular ultrasound and cardiac computed tomography were performed to quantify noncoronary atherosclerosis and coronary calcification.RESULTS: When adjusted for conventional risk factors, very short sleep duration was independently associated with a higher atherosclerotic burden with 3-dimensional vascular ultrasound compared to the reference group (odds ratio: 1.27; 95% confidence interval: 1.06 to 1.52; p = 0.008). Participants within the highest quintile of sleep fragmentation presented a higher prevalence of multiple affected noncoronary territories (odds ratio: 1.34; 95% confidence interval: 1.09 to 1.64; p = 0.006). No differences were observed regarding coronary artery calcification score in the different sleep groups.CONCLUSIONS: Lower sleeping times and fragmented sleep are independently associated with an increased risk of subclinical multiterritory atherosclerosis. These results highlight the importance of healthy sleep habits for the prevention of cardiovascular disease.Copyright © 2019. Published by Elsevier Inc. PMID: 30654884
Lean Six Sigma Tools for a Glovebox Glove Integrity Program (2010)

Programmatic operations at the Los Alamos National Laboratory (LANL) Plutonium Facility involve working with various amounts of plutonium, uranium, and other highly toxic, alpha-emitting materials. The spread of radiological contamination on surfaces, airborne contamination, and excursions of contaminants into the operator's breathing zone are prevented through use of a variety of gloveboxes. Evaluation of the glovebox configuration shows that the glovebox gloves are the most vulnerable part of this engineering control. Recognizing this vulnerability, the Glovebox Glove Integrity Program was developed to minimize or prevent glovebox glove events, namely, loss of confinement of the glovebox through an unplanned opening in the glovebox glove. In addition, LANL established the Lean Manufacturing and Six Sigma business practices (LSS) program to effectively improve administrative and engineering controls and work processes. The LSS tools were developed to analyze, optimize, and manage glovebox glove process performance with meaningful data. This includes identifying process scope and ownership and measuring performance. This paper discusses LSS tools, provides examples of LSS tools, and shows how managers use the results to make decisions. This effort contributes to LANL Continuous Improvement Program by providing information that improves the efficiency, cost effectiveness, and formality of glovebox operations.
An alternative frequency domain beamforming (2005)

The aim of this paper is to present a frequency-domain beamforming technique for ultrasound medical imaging systems, which is based on the seismic migration algorithm. The proposed procedure is computationally very efficient, and since an entire image can be reconstructed from each insonification, it permits us to dramatically improve the frame-rate achievable. The method allows for the emission of an unfocused wave when using linear or convex transducers, whereas a cylindrical wave illumination is needed with phased arrays, for ensuring a suitable field-of-view. Promising results of the proposed algorithm, applied both on phantom and live tissue data, are presented.
Supplementary Figure 3 from Genetic Profiling Identifies Two Classes of Soft-Tissue Leiomyosarcomas with Distinct Clinical Characteristics (2023)

&lt;p&gt;PDF file - 52K, Kaplan-Meier curves of overall survival according to age (A), tumor size (B), tumor location (C) and tumor grade (D)&lt;/p&gt;
SPINE: a domain‐specific framework for rapid prototyping of WBSN applications (2010)

Abstract Wireless body sensor networks (WBSNs) enable a broad range of applications for continuous and real‐time health monitoring and medical assistance. Programming WBSN applications is a complex task especially due to the limitation of resources of typical hardware platforms and to the lack of suitable software abstractions. In this paper, SPINE (signal processing in‐node environment), a domain‐specific framework for rapid prototyping of WBSN applications, which is lightweight and flexible enough to be easily customized to fit particular application‐specific needs, is presented. The architecture of SPINE has two main components: one implemented on the node coordinating the WBSN and one on the nodes with sensors. The former is based on a Java application, which allows to configure and manage the network and implements the classification functions that are too heavy to be implemented on the sensor nodes. The latter supports sensing, computing and data transmission operations through a set of libraries, protocols and utility functions that are currently implemented for TinyOS platforms. SPINE allows evaluating different architectural choices and deciding how to distribute signal processing and classification functions over the nodes of the network. Finally, this paper describes an activity monitoring application and presents the benefits of using the SPINE framework. Copyright © 2010 John Wiley &amp; Sons, Ltd.
New Probabilistic Network Models and Algorithms for Oncogenesis (2006)

Chromosomal aberrations in solid tumors appear in complex patterns. It is important to understand how these patterns develop, the dynamics of the process, the temporal or even causal order between aberrations, and the involved pathways. Here we present network models for chromosomal aberrations and algorithms for training models based on observed data. Our models are generative probabilistic models that can be used to study dynamical aspects of chromosomal evolution in cancer cells. They are well suited for a graphical representation that conveys the pathways found in a dataset. By allowing only pairwise dependencies and partition aberrations into modules, in which all aberrations are restricted to have the same dependencies, we reduce the number of parameters so that datasets sizes relevant to cancer applications can be handled. We apply our framework to a dataset of colorectal cancer tumor karyotypes. The obtained model explains the data significantly better than a model where independence between the aberrations is assumed. In fact, the obtained model performs very well with respect to several measures of goodness of fit and is, with respect to repetition of the training, more or less unique.
The substrate influence on the optoelectronic properties of 2D materials (2018)

2D materials are known for their highly susceptible to environmental influence. Here we show the influence of different substrates to the exciton/trion related bandgap engineering of two typical materials, MoS2 and WS2 nanosheets.
Supplementary Data from Molecular Mechanisms of Acquired Resistance to MET Tyrosine Kinase Inhibitors in Patients with MET Exon 14–Mutant NSCLC (2023)

&lt;p&gt;Supplementary Figure Legends&lt;/p&gt;
Polymer Processing - Process Technology of Polymer Production (2021)

No AccessPlastics Compounding and Polymer ProcessingDec 2021Polymer Processing - Process Technology of Polymer ProductionKlemens KohlgrüberKlemens Kohlgrüberhttps://doi.org/10.3139/9781569908389.002SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2021Pages: 9-60Print ISBN: 978-1-56990-837-2eISBN: 978-1-56990-838-9 Copyright & Permissions© 2022 Carl Hanser Verlag GmbH & Co. KGPDF downloadLoading ...
Software design issues for ubiquitous computing (2002)

The defining characteristic of ubiquitous computing is the attempt to break away from the traditional desktop computing paradigm and move computational power into the environment that surrounds the user. Increasing miniaturization brought on by advances in areas such as VLSI design means that we will soon be able to instrument our environments in order to realize the dream of ubiquitous computing. The promise of ubiquitous computing, however, is that the increased pervasiveness of computation will lead to less intrusive and more valuable services to the end user. For this dream to be realized we need to accompany hardware advances with advances in software technology. In this paper, the author discusses some software challenges for ubiquitous computing.
Prospects of centrifugation of cells, liquids, and gases at multimillion g-forces in magnetically suspended microrotors (1986)

Prototypes of magnetically suspended rotors for centrifugation of cells, organic and inorganic solutions, and gases are Fe-containing glass and metallic hollow microspheres 0.1–2 mm in diameter, composite steel-glass disks up to 1 cm, and microspheres of porous steel and Fe-impregnated porous glass. Fe-coated microcapsules with cells can be used for lower centrifugal forces. Predictable applications include cell hybridization and homogenization, spinning of samples at the ‘‘magic angle’’ in nuclear-magnetic resonance (NMR), intensification of nuclear fusion by high-speed rotation of microspheres with deuterium and tritium, and other examples. Rotor contents can be examined under the microscope during centrifugation, or the spinning rotor can be frozen and its contents freeze dried for further examination.
Hot-Carrier-Induced Degradation on 0.1 µm Partially Depleted Silicon-On-Insulator Complementary Metal-Oxide-Semiconductor Field-Effect-Transistor (2003)

Hot-carrier-induced degradation of partially depleted silicon-on-insulator (SOI) complementary metal-oxide-semiconductor field-effect-transistors (CMOSFET)s at various applied voltages and temperatures was investigated with respect to 0.1 µm body-contact (BC-SOI) and floating-body (FB-SOI) devices with 2 nm gate oxide. In our experiment, it is found that the valence-band electron tunneling is the main factor of device degradation for the SOI CMOSFET. In the FB-SOI nMOSFET, both the floating body effect (FBE) and the parasitic bipolar transistor effect (PBT) affect the hot-carrier-induced degradation of device characteristics. For FB-SOI nMOSFET maximum hot-carrier-induced degradation is inversely temperature dependent compared to BC-SOI nMOSFET. Without apparent FBE on pMOSFET, the worst hot-carrier stress condition and temperature dependence of maximum hot-carrier-induced degradation are similar for both 0.1 µm SOI pMOSFETs.