gebhart/patrepeval huggingface dataset:
The MEK1/2-inhibitor ATR-002 efficiently blocks SARS-CoV-2 propagation and alleviates pro-inflammatory cytokine/chemokine responses (2022)

Coronavirus disease 2019 (COVID-19), the illness caused by a novel coronavirus now called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to more than 260 million confirmed infections and 5 million deaths to date. While vaccination is a powerful tool to control pandemic spread, medication to relieve COVID-19-associated symptoms and alleviate disease progression especially in high-risk patients is still lacking. In this study, we explore the suitability of the rapid accelerated fibrosarcoma/mitogen-activated protein kinase/extracellular signal-regulated kinase (Raf/MEK/ERK) pathway as a druggable target in the treatment of SARS-CoV-2 infections. We find that SARS-CoV-2 transiently activates Raf/MEK/ERK signaling in the very early infection phase and that ERK1/2 knockdown limits virus replication in cell culture models. We demonstrate that ATR-002, a specific inhibitor of the upstream MEK1/2 kinases which is currently evaluated in clinical trials as an anti-influenza drug, displays strong anti-SARS-CoV-2 activity in cell lines as well as in primary air-liquid-interphase epithelial cell (ALI) cultures, with a safe and selective treatment window. We also observe that ATR-002 treatment impairs the SARS-CoV-2-induced expression of pro-inflammatory cytokines, and thus might prevent COVID-19-associated hyperinflammation, a key player in COVID-19 progression. Thus, our data suggest that the Raf/MEK/ERK signaling cascade may represent a target for therapeutic intervention strategies against SARS-CoV-2 infections and that ATR-002 is a promising candidate for further drug evaluation.
Some historical remarks concerning these conferences: With emphasis on the X-ray component (1990)

First Page
Exploring return to work for patients with head and neck cancer (2023)

This study revealed the experiences and challenges of RTW patients with HNC. The results allowed us to identify patients' concerns and ways that healthcare providers could improve the RTW process. Future studies may develop tailored approaches for RTW in healthcare and government policies.
The Context-Dependent Additive Recurrent Neural Net (2018)

Quan Hung Tran, Tuan Lai, Gholamreza Haffari, Ingrid Zukerman, Trung Bui, Hung Bui. Proceedings of the 2018 Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies, Volume 1 (Long Papers). 2018.
Differential tuberculin testing in Lagos. (1982)

School children in lagos were tested with PPD-S and one of the following tuberculins simultaneously namely PPD-G, PPD-A, PPD-Y, PPD-F, and PPD-PL. The tuberculins were prepared from Mycobacterium tuberculosis, the Gause organism, M. avium, M. Kansasii, M. fortuitum and M. marinum respectively. It was found that for the different antigens, among those children who had indurations from 0 to 4 mm those small sized reactions wer generally due to sensitization by opportunist mycobacteria. In contrast to this, among those who had indurations over 10 mm, the reactions were due to sensitization by the human tubercle bacillus. Testing of patients with bacteriologically and radiologically proved tuberculosis showed that practically all of them reacted in an expected manner, i.e. PPD-S elicited larger reactions than PPD-Y, PPD-A, PPD-G, PPD-LL and PPD-F.
Communications: Immunohistochemical Characterization of a Monoclonal Antibody againstCeratomyxa shasta (1990)

The location of the antigen binding site of a monoclonal antibody (MAb) against Ceratomyxa shasta was investigated by transmission electron microscopy with immunogold labeling techniques and by immunoenzymatic labeling of the parasite in histological sections. Specific binding by the MAb was observed in the cytoplasm of the primary (mother) cell. Labeled antibody was not observed in the cytoplasm of the developing secondary cells of the parasite nor in the nucleus of either the primary or secondary cells. Uses for this MAb in diagnostics and research are discussed.
Rubber-Modified Polymers. Location of Block Copolymers in Two-Phase Materials (1975)

In heterophase polymeric materials, outstanding mechanical properties are obtainable only by regulating dispersed phase particle size and adhesion between phases, usually by adding block or graft copolymers. The emulsifying effect of block and graft copolymers was demonstrated for the PS-PI system. Since characteristics of the blend polymers (e.g., molecular weight and composition) determine whether the copolymer is situated in the continuous phase, in the dispersed phase, or at the interface, we tried to establish the conditions for the last. Different techniques for locating a PS-PI block copolymer were studied: use of a copolymer containing a fluorescent group, x-ray scanning microanalysis, and quantitative analysis of the gel formed after crosslinking the elastomeric phase by γ-irradiation. For these PS-PI blends, the amount of copolymer at the interface correlated with impact resistance.
Synthesis and Properties of Hexyl End-Capped Thiophene Oligomers Containing Anthracene Moiety in the Center (2007)

A series of new organic semiconductors hexyl end-capped thiophene-anthracene oligomers containing the anthracene moiety in the center of the oligomers are synthesized. The target oligomers have been obtained by Stille coupling reactions as key step reactions. The synthesized thiophene-anthracene oligomers were characterized by 1H-NMR, 13C-NMR and high-resolution mass spectroscopy, respectively. All of the oligomers are soluble in chlorinated solvents. Their optical, thermal and electrochemical properties were measured. The hexyl end-capped oligomers and their unsubstituted oligomers exhibit the same absorption behavior in dilute toluene solution. Hexyl end-capped bis-terthienylanthracene oligomer is observed to show liquid crystalline mesophase at 166 oC in heating process. The thermal analyses as well as the electrochemical measurement data indicate that the designed materials show better thermal and oxidation stability than the corresponding oligothiophenes without anthracene core. Fluorescence lifetimes and fluorescence quantum yields of the thiophene-anthracene oligomers are measured to be 10-14 ps and 3.4-9.9 × 10?3 which are much shorter and lower than those of oligothiophenes respectively.
ChemInform Abstract: Carbon‐Carbon Bond Formation by Intermolecular Radical Reaction. SmI2‐ Promoted Carbonyl‐Alkyne Reductive Coupling. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Chicken or egg: financial development and economic growth in China, 1992-2004 (2005)

This paper contributes to the empirical finance-growth literature by examining the relationship between financial depth, banking sector development, stock market development and economic growth in China. After an extensive survey on recent financial reforms in China, we apply Granger (non-)causality tests for non-stationary variables to examine long-run and short-run causality between economic growth and financial development. We find positive relationships between financial depth, banking sector development and growth. However, stock market development does not seem to have a positive effect on long-run economic growth.
Brain disconnections link structural connectivity with function and behaviour (2020)

Brain lesions do not just disable but also disconnect brain areas, which once deprived of their input or output, can no longer subserve behaviour and cognition. The role of white matter connections has remained an open question for the past 250 years. Based on 1333 stroke lesions, here we reveal the human Disconnectome and demonstrate its relationship to the functional segregation of the human brain. Results indicate that functional territories are not only defined by white matter connections, but also by the highly stereotyped spatial distribution of brain disconnections. While the former has granted us the possibility to map 590 functions on the white matter of the whole brain, the latter compels a revision of the taxonomy of brain functions. Overall, our freely available Atlas of White Matter Function will enable improved clinical-neuroanatomical predictions for brain lesion studies and provide a platform for explorations in the domain of cognition.
Pyrroles XIV. Mannich Bases of 2,5-Substituted Pyrroles1 (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPyrroles XIV. Mannich Bases of 2,5-Substituted Pyrroles1WERNER HERZ and ROBERT L. SETTINECite this: J. Org. Chem. 1959, 24, 2, 201–204Publication Date (Print):February 1, 1959Publication History Published online1 May 2002Published inissue 1 February 1959https://pubs.acs.org/doi/10.1021/jo01084a013https://doi.org/10.1021/jo01084a013research-articleACS PublicationsRequest reuse permissionsArticle Views225Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
RES-701-2, a Novel and Selective Endothelin Type B Receptor Antagonist Produced by Streptomyces sp. II. Determination of the Primary Structure. (1995)

Endothelins (ETs) are a family of potent vasoactive peptides found in at least three distinct isoforms: ET-1, ET-2, and ET-31}. Two major subtypes of endothelin receptors, termed ETAand ETB, have been identified in various target cells2). It is well known that ETs act on these Gprotein-coupled receptors and exert multiple pharmacological effects3). As the development of potent and selective endothelin receptor antagonists facilitates the understanding of endothelin4), the function of ETB
Performance of p16/Ki-67 Immunostaining to Detect Cervical Cancer Precursors in a Colposcopy Referral Population (2012)

p16/Ki-67 testing could reduce referral to colposcopy by almost half while detecting the most severe cases of CIN3. The high sensitivity of p16/Ki-67 with significantly improved specificity compared with HPV testing makes p16/Ki-67 a viable option for LSIL triage. Further studies are required to evaluate p16/Ki-67 as triage marker in HPV-based screening strategies.
Cytotoxic T-Lymphocyte–Defined Human Minor Histocompatibility Antigens With a Restricted Tissue Distribution (1998)

Cytotoxic T lymphocytes (CTL) specific for human minor histocompatibility (H) antigens can be isolated from the blood of major histocompatibility complex (MHC)-matched allogeneic bone marrow transplant (BMT) recipients and may play a prominent role in the graft-versus-host (GVH) and graft-versus-leukemia (GVL) reactions (Tsoi et al, J Immunol 125:2258, 1980; Tsoi et al, Transplant Proc 15:1484, 1983; Goulmy et al, Nature 302:159, 1983; Irle et al, Transplantation 40:329, 1985; and Niederwieser et al, Blood 81:2200, 1993). The identification of minor H antigens that are expressed in hematopoietic cells, including leukemic cells, but not in fibroblasts and other tissue types has suggested that such tissue-restricted antigens could potentially serve as targets for T-cell immunotherapy to enhance GVL activity without inducing GVH disease (de Bueger et al, J Immunol 149:1788, 1992; van der Harst et al, Blood 83:1060, 1994; and Dolstra et al, J Immunol 158:560, 1997). To explore the feasibility of this strategy, donor CD3+CD8+ CTL clones specific for recipient minor H antigens were isolated and characterized from allogeneic BMT recipients. CTL clones were obtained from the majority of donor/recipient pairs. Seventeen distinct minor H antigens distinguishable by their MHC-restricting allele, population frequency, and/or distribution of tissue expression were defined by 56 CD3+CD8+ CTL clones isolated from these patients. The MHC-restricting alleles for these CTL clones included HLA-A2 and HLA-B7, which had previously been shown to present minor H antigens to CTL, as well as HLA-A3, -A11, -B8, -B53, and -Cw7, which had not previously been described to present minor H antigens to CTL. Estimated phenotype frequencies for these 17 distinct minor H antigens range from 0.17 to 0.92. In vitro cytotoxicity assays using hematopoietic cells and fibroblasts as target cells showed that 5 of the 17 minor H antigens were expressed in both hematopoietic cells and fibroblasts. However, 12 were presented for CTL recognition only by hematopoietic cells and not by dermal fibroblasts derived from the same donors. These results significantly extend the spectrum of CTL-defined human minor H antigens that could potentially serve as target antigens for cellular immunotherapy to promote GVL activity after allogeneic BMT.
Thermally Induced Phase Transitions and Morphological Changes in Organoclays (2004)

Thermal transitions and morphological changes in Cloisite organoclays were investigated by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Fourier transform infrared (FTIR) spectroscopy, and in situ simultaneous small-angle X-ray scattering (SAXS) and wide-angle X-ray diffraction (WAXD) over the temperature range of 30-260 degrees C. On the basis of DSC and FTIR results, the surfactant component in organoclays was found to undergo a melting-like order-disorder transition between 35 and 50 degrees C. The transition temperatures of the DSC peaks (Ttr) in the organoclays varied slightly with the surfactant content; however, they were significantly lower than the melting temperature of the free surfactant (dimethyldihydrotallowammonium chloride; Tm = 70 degrees C). FTIR results indicated that within the vicinity of Ttr, the gauche content increased significantly in the conformation of surfactant molecules, while WAXD results did not show any change in three-dimensional ordering. Multiple scattering peaks were observed in SAXS profiles. In the SAXS data acquired below Ttr, the second scattering peak was found to occur at an angle lower than twice that of the first peak position (i.e., nonequidistant scattering maxima). In the data acquired above Ttr, the second peak was found to shift toward the equidistant position (the most drastic shift was seen in the system with the highest surfactant content). Using a novel SAXS modeling technique, we suggest that the appearance of nonequidistant SAXS maxima could result from a bimodal layer thickness distribution of the organic layers in organoclays. The occurrence of the equidistant scattering profile above Ttr could be explained by the conversion of the bimodal distribution to the unimodal distribution, indicating a redistribution of the surfactant that is nonbounded to the clay surface. At temperatures above 190 degrees C, the scattering maxima gradually broadened and became nonequidistant again but having the second peak shifted toward a scattering angle higher than twice the first peak position. The changes in SAXS patterns above 190 degrees C could be attributed to the collapse of organic layers due to desorption and/or degradation of surfactant component, which was supported by the TGA data.
3D Point Cloud Reduction Using Mixed-Integer Quadratic Programming (2013)

Large scale 3D image localization requires computationally expensive matching between 2D feature points in the query image and a 3D point cloud. In this paper, we present a method to accelerate the matching process and to reduce the memory footprint by analyzing the view-statistics of points in a training corpus. Given a training image set that is representative of common views of a scene, our approach identifies a compact subset of the 3D point cloud for efficient localization, while achieving comparable localization performance to using the full 3D point cloud. We demonstrate that the problem can be precisely formulated as a mixed-integer quadratic program and present a pointwise descriptor calibration process to improve matching. We show that our algorithm outperforms the state-of-theart greedy algorithm on standard datasets, on measures of both point-cloud compression and localization accuracy.
Multiple Cycle Frequencies Estimation Under Cochannel Interference (2018)

In this letter, two cycle frequencies estimation algorithms are proposed to estimate the number of weak cyclostationary signals and their cycle frequencies in the presence of higher power interferer signal. Both cycle frequencies estimation algorithms are eigenanalysis-based methods that use the cyclic autocorrelation function of the received signals. In particular, a new eigen-analysis cyclic null spectrum is introduced to determine the number of cyclostationary signals and estimate their cycle frequencies. The performances of the proposed cycle frequency estimation algorithms are demonstrated with numerical examples and compared with the existing cycle frequency estimation algorithms. It is shown that both the proposed cycle frequencies estimation algorithms have better accuracy than the existing methods and could work with small sample size for faster estimation.
Absolute NO and OH Concentrations During Diesel Combustion Process by Multiwavelength Absorption Spectroscopy (2002)

&lt;div class="htmlview paragraph"&gt;Conventional methods to measure gas concentrations and, in particular, NO are typically based on sampling by valve, sample treatment and subsequent analysis. These methods suffer low spatial and temporal resolution. The introduction of high energy lasers in combination with fast detection systems allowed to detect the NO distribution inside optically accessible Diesel engines. In this paper, a high spatial and temporal resolution in-situ technique based on ultraviolet - visible absorption spectroscopy is proposed. The characterization of the combustion process by the detection of gaseous compounds from the start of combustion until the exhaust phase was performed. In particular, this technique allows the simultaneous detection of NO and OH absolute concentrations inside an optically accessible Diesel combustion chamber. Using a numerical procedure for retrieving of optical data, supported by the knowledge of local temperature, the temporal evolution and spatial distributions of OH radical and NO were evaluated.&lt;/div&gt;
A fluxless bonding technology using indium-silver multilayer composites (1997)

A fluxless bonding process has been developed using indium-silver multilayer composites deposited on silicon and GaAs wafers in one high vacuum cycle to inhibit the oxidation of the bonding media. The in situ formation of AgIn/sub 2/ intermetallic outer layer protects the inner media from oxidation when exposed to atmosphere. The bonding process is performed at 180/spl deg/C temperature in inert environment to prevent oxygen from getting into the specimens. High quality joints are produced as confirmed by a scanning acoustic microscope. The joints are very uniform with a thickness of 4 /spl mu/m. Scanning electron microscopy (SEM) evaluations reveal that the joint is composed of indium matrix with embedded intermetallic grains. Neither flux nor scrubbing motion is used in the bonding process. The process should be valuable in manufacturing applications where the use of flux cannot be tolerated.
Fresnel Hologram Fast Computation Method employing Difference Method. (1998)

ホログラムが微細な画素構造を有していることから, 隣接した画素間の差分を利用して計算機合成ホログラムを高速に近次計算する方法を検討した.その結果, 再生像に影響しない範囲で高速な計算が実現できた.
Física mecánica para ciencias e ingenierías (2020)

El propósito de este libro es fortalecer los conocimientos conceptuales de Física Mecánica a través de ejemplos y ejercicios de aplicaciones teniendo en cuenta un enfoque práctico y el desarrollo de elementos de competencias, fortaleciéndolas por medio de aplicaciones tipo Saber Pro. Cabe destacar la importancia de los conocimientos del curso, el cual tiene mucha aplicación a la ingeniería, por contribuir a generar una de las bases fundamentales de las demás temáticas de las Ingenierías. Es por estas razones que, el estudiante de hoy en día debe adquirir todas las herramientas que le sean de utilidad en sus proyectos y labores futuras. En este libro se tratan temas fundamentales de la Física Mecánica, desde Cinemática hasta Conservación del Momento Angular, cada tema es explicado con los conceptos asociados, ilustrados con ejemplos y desarrollado por parte de los estudiantes, como parte del trabajo independiente. Finalmente, se reconoce el esfuerzo realizado por los autores en la dedicación del texto. Así como el agradecimiento al equipo editorial por sus contribuciones y apoyo. Esperamos que este libro sea una herramienta de trabajo implementado por los docentes del departamento de Ciencias Naturales y Exactas en los procesos de enseñanza y una guía para los estudiantes en su proceso de aprendizaje.
Adult Transplant Hepatologists’ Perceptions of the Transition From Pediatric to Adult Care: A National Survey. (2014)

Background: Adult transplant hepatologists face challenges providing care to patients who received liver transplants during childhood. Understanding these challenges may identify opportunities to improve transition to adult care. Methods: We conducted a web-based, national survey of adult transplant hepatologists to assess factors that may impact the transition from pediatric to adult care. Results: 236/407 (58% participation rate) completed the survey. The sample was 75% male, 51% <45 years old, and 63% white. Most of their pediatric recipients at their first adult clinic visit had an average age ≥21 years (54%). A third noted that recipients came to visits without a parent or guardian (33%), and that recipients had inadequate knowledge of their condition (30%). Few (16%) respondents reported having a formal transition program. The majority of respondents identified patients’ poor medication adherence (70%), limited ability and knowledge to manage their own condition (54%), and inadequate knowledge of past medical/surgical history (51%) as the main challenges to caring for their newly transitioned patients. Respondents at centers with formal transition programs, compared to those without, reported that their patients were more knowledgeable and able to discuss issues of substance use (47% vs. 22%, p = 0.002) and sexuality and quality of life (38% vs. 21%, p = 0.03). Respondents with transition programs saw more patients 18-20 years old at initial referral (61% vs. 43%, p = 0.06) and were more likely to have adequate knowledge of pediatric transplant issues than respondents without transition programs (65% vs. 48%, p = 0.08). Conclusions: Adult hepatologists reported numerous challenges to caring for patients who have transitioned from the pediatric to the adult clinic. Given that current transition programs may be associated with enhanced provider and patient knowledge, early interventions may optimize this transition and thus require further study.