gebhart/patrepeval huggingface dataset:
Composite Floquet scattering matrix for the analysis of time-modulated systems (2017)

We present a rigorous and efficient semi-analytical method for the analysis of complex periodically time-varying linear systems using generalized Floquet scattering matrices (FSMs). Our approach can be applied to linear networks with an arbitrary number of periodically time-varying multi-port elements. As an example, this method is applied to an angular-momentum biased magnet-less circulator, showing excellent agreement with other numerical approaches.
Design and commissioning of the D0 vertical nondispersive overpass in the Fermilab Main Ring (2003)

A vertical overpass in the Fermilab Main Ring around a future D0 proton-antiproton collision detector was designed and built to raise the initial luminosity for collider physics. The overpass provides a better dispersion match between the Main Ring and the Tevatron, and in the Main Ring substantially lowers the vertical beam size arising from momentum spread. This has also improved the overall efficiency and beam intensity of the Main Ring. Vertical dispersion was measured before and after completing the overpass. A high degree of correspondence was obtained between the predicted and measured values of vertical dispersion around the whole Main Ring. The Main Ring performance improved considerably with respect to beam intensity (which was raised from 1.2*10/sup 12/ to 1.8*10/sup 12/ protons per batch) as well as with respect to the Main Ring overall efficiency (which was raised from 85% up to 93%).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Automatic generation of IC component configuration data (2008)

Abstract Chip mounters and surface mount device (SMD) inspection systems use image processing techniques for the placement of SMDs onto printed circuit boards (PCB) and the inspection of SMDs. Such techniques require the component configuration data which define the shape of SMDs; however, the creation of this data is currently not automated. The goal of this paper is to offer a system that generates component configuration data automatically by processing images of SMDs. There are several target components, such as IC, BGA (ball grid array), chips, connectors, etc., for which data can be generated. In this paper we will focus on generation of data for IC components. © 2008 Wiley Periodicals, Inc. Electr Eng Jpn, 165(4): 76–83, 2008; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/eej.20686
Air Pollution: Remote Detection of Several Pollutant Gases with a Laser Heterodyne Radiometer (1974)

An infrared heterodyne radiometer with a spectral resolution of 0.04 reciprocal centimeters has been used to remotely detect samples of ozone, sulfur dioxide, ammonia, and ethylene at room temperature, and samples of nitric oxide at 390K. Each gas was observed in a background of nitrogen or oxygen at atmospheric pressure. Sensitivities to some of these gases are adequate for detection of ambient concentrations as low as a few parts per billion.
FcRn-targeting and ROS-responsive Fedratinib-incorporated Nanoparticles Alleviate Asthma by Inducing Eosinophil Apoptosis (2022)

Background: Reducing the number of airway eosinophils is critical for treating eosinophilic asthma. The JAK2-STATs pathway is essential for myelopoiesis of eosinophils and production of type I and II cytokines, and therefore can be a novel target for intervention of eosinophilic asthma. Here, we aimed to demonstrate the apoptosis-inducing potential of Fedratinib (FDTN), a JAK2-specific inhibitor, and test the efficacy of the ROS-responsive, FcRn-targeting and FDTN-caged nanoparticles on eosinophilic asthma alleviation. Methods: The apoptosis-inducing potential of FDTN in eosinophils from asthma patients was assessed by flow cytometry, and light and electron microscopy. FDTN-caged nanoparticles (NPs-FDTN) were designed to ROS responsive and modified with Fc portion of IgG through the avidin-biotin interaction. The biological availability of NPs-FDTN was assembled via biochemical and immunological analysis, and the therapeutic effects were investigated in eosinophilic asthma model mice by comparing free FDTN and budesonide treatment. Results: FDTN blocked the JAK2/STAT5 pathway and activated the intrinsic pathway of apoptosis in eosinophils in a concentration-dependent manner. NPs-FDTN crossed the epithelial barrier via the Fc/FcRn-mediated transcytosis, bypassed the lysosome and entered the inflammatory microenvironment. Caged FDTN was released from the nanoparticles in the presence of ROS. Compared to free FDTN, the residence time of FDTN in the lung parenchyma was prolonged and the therapeutic effects were improved when delivered in nanoparticles. Conclusion: Ros-responsive, FcRn-targeting and FDTN-caged nanoparticles overcame the airway epithelial barrier and improved the bioavailability on eosinophil apoptosis. This study provides a fancy and safe therapeutic strategy for treatment of eosinophilic asthma.
CDK7 controls E2F- and MYC-driven proliferative and metabolic vulnerabilities in multiple myeloma (2023)

Therapeutic targeting of CDK7 has proven beneficial in preclinical studies, yet the off-target effects of currently available CDK7 inhibitors make it difficult to pinpoint the exact mechanisms behind MM cell death mediated by CDK7 inhibition. Here, we show that CDK7 expression positively correlates with E2F and MYC transcriptional programs in cells from patients with multiple myeloma (MM); its selective targeting counteracts E2F activity via perturbation of the cyclin-dependent kinases/Rb axis and impairs MYC-regulated metabolic gene signatures translating into defects in glycolysis and reduced levels of lactate production in MM cells. CDK7 inhibition using the covalent small-molecule inhibitor YKL-5-124 elicits a strong therapeutic response with minimal effects on normal cells, and causes in vivo tumor regression, increasing survival in several mouse models of MM including a genetically engineered mouse model of MYC-dependent MM. Through its role as a critical cofactor and regulator of MYC and E2F activity, CDK7 is therefore a master regulator of oncogenic cellular programs supporting MM growth and survival, and a valuable therapeutic target providing rationale for development of YKL-5-124 for clinical use.
BAD Is a Pro-survival Factor Prior to Activation of Its Pro-apoptotic Function (2004)

The mammalian BAD protein belongs to the BH3-only subgroup of the BCL-2 family. In contrast to its known pro-apoptotic function, we found that endogenous and overexpressed BAD(L) can inhibit cell death in neurons and other cell types. Several mechanisms regulate the conversion of BAD from an anti-death to a pro-death factor, including alternative splicing that produces the N-terminally truncated BAD(S). In addition, caspases convert BAD(L) into a pro-death fragment that resembles the short splice variant. The caspase site that is selectively cleaved during cell death following growth factor (interleukin-3) withdrawal is conserved between human and murine BAD. A second cleavage site that is required for murine BAD to promote death following Sindbis virus infection, gamma-irradiation, and staurosporine treatment is not conserved in human BAD, consistent with the inability of human BAD to promote death with these stimuli. However, loss of the BAD N terminus by any mechanism is not always sufficient to activate its pro-death activity, suggesting that the N terminus is a regulatory domain rather than an anti-death domain. These findings suggest that BAD is more than an inert death factor in healthy cells; it is also a pro-survival factor, prior to its role in promoting cell death.
Assessment of corticosteroid (CS)-associated adverse events (AEs) with long-term (LT) exposure to low-dose prednisone (P) given with abiraterone acetate (AA) to metastatic castration-resistant prostate cancer (mCRPC) patients (Pts). (2015)

169 Background: AA is the prodrug of abiraterone, which inhibits CYP17A1 and testosterone synthesis and prolongs survival of mCRPC pts. A low dose of P is given when AA is administered to mCRPC pts. LT use of moderate-/high-dose CS has an established AE profile. We investigated whether LT use of low-dose P with or without AA led to CS-associated AEs. Methods: 2,267 mCRPC pts in COU-AA-301 and COU-AA-302 received 5 mg bid P, representing 2,006 pt-yrs of P exposure. 1,333 pts received AA + P. We utilized an inclusive Standardized MedDRA Queries–oriented approach to identify 112 preferred terms for known CS-associated AEs from both databases. CS-associated AEs during 3-mo exposure intervals and across all exposure to P were assessed. Results: The overall incidence of CS-associated AEs for any P exposure was 25%, 26%, and 23% for all pts, AA + P, and P alone, respectively. The incidence of grade ≥ 3 CS-associated AEs with any P exposure was 5%, 5%, and 4% for all pts, AA + P, and P alone, respectively. The most common grade ≥ 3 CS-associated AEs occurring in ≥ 0.1% of all pts were hyperglycemia (2%), cataract (0.4%), diabetes mellitus (0.4%), gastrointestinal hemorrhage (0.3%), adrenal insufficiency (0.1%), hip fracture (0.1%), melena (0.1%), and spinal osteoporotic compression fracture (0.1%). The overall incidence of weight increase (grade 1/2 only) was 4%, 4%, and 5% for all pts, AA + P, and P alone, respectively. Most were grade 1 (3.4%).When assessed by duration of exposure (3-mo intervals up to ≥30 mo), grade ≥ 3 CS-associated AEs fluctuated between 1% and 2%, but no discernable trend was observed. The observed change in weight from baseline showed no apparent increase over time. Conclusions: With over 2,000 pt-yrs of exposure, low-dose P given with or without AA is associated with an overall low incidence of CS-associated AEs. The frequencies of CS-associated AEs were low with increased duration of exposure to P. Clinical trial information: NCT00638690 , NCT00887198 .
Isolation and Characterization of Plasmid pUOl Mediating Dehalogenation of Haloacetate and Mercury Resistance inMoraxellasp. B (1981)

Journal Article Isolation and Characterization of Plasmid pUOl Mediating Dehalogenation of Haloacetate and Mercury Resistance in Moraxella sp. B Get access Haruhiko Kawasaki, Haruhiko Kawasaki Department of Agricultural Chemistry, College of Agriculture, University of Osaka Prefecture, Sakai, Osaka 591, Japan Search for other works by this author on: Oxford Academic Google Scholar Hitoshi Yahara, Hitoshi Yahara Department of Agricultural Chemistry, College of Agriculture, University of Osaka Prefecture, Sakai, Osaka 591, Japan Search for other works by this author on: Oxford Academic Google Scholar Kenzo Tonomura Kenzo Tonomura Department of Agricultural Chemistry, College of Agriculture, University of Osaka Prefecture, Sakai, Osaka 591, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 45, Issue 6, 1 June 1981, Pages 1477–1481, https://doi.org/10.1080/00021369.1981.10864721 Published: 01 June 1981 Article history Received: 26 January 1981 Published: 01 June 1981
Hydrothermal Synthesis and Structure Determination from Powder Data of New Three-Dimensional Titanium(IV) Diphosphonates Ti(O3P−(CH2)n−PO3) or MIL-25n (n = 2, 3) (2001)

Ti(O(3)P-(CH(2))(n)-PO(3)) or MIL-25(n) (n = 2, 3) were prepared under hydrothermal conditions (4 days, 463 K, autogenous pressure). Their structures were determined ab initio from X-ray diffraction powder data. MIL-25(2) is triclinic (space group P-1 (no. 2)), with a = 5.033(1), b = 5.092(1), c = 6.859(1) A, alpha = 95.860(1) degrees, beta = 99.994(1) degrees, gamma = 118.217(1) degrees, and Z = 2. MIL-25(3) exhibits an orthorhombic symmetry (space group Cm2m (no. 38)), with a = 5.230(1), b = 8.451(1), c = 17.400(2) A, and Z = 4. Their three-dimensional structures are built up from TiO(6) titanium(IV) octahedra linked together via diphosphonate groups. This leads to pillared structures whose inorganic sheets are closely related to those of the alphaTiP titanium phosphate structure.
MATING BEHAVIOR OF PEROMYSCUS-POLIONOTUS PEROMYSCUS-TRUEI (1967)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Facility Location with Matroid or Knapsack Constraints (2014)

In the classical k-median problem, we are given a metric space and want to open k centers so as to minimize the sum (over all the vertices) of the distance of each vertex to its nearest open center. In this paper we present the first constant-factor approximation algorithms for two natural generalizations of this problem that handle matroid or knapsack constraints. In the matroid median problem, there is an underlying matroid on the vertices and the set of open centers is constrained to be independent in this matroid. When the matroid is uniform, we recover the k-median problem. Another previously studied special case is the red-blue median problem where we have a partition matroid with two parts. Our algorithm for matroid median is based on rounding a natural linear programming relaxation in two stages, and it relies on a connection to matroid intersection. In the knapsack median problem, centers have weights and the total weight of open centers is constrained to be at most a given capacity. When all weights are uniform, this reduces to the k-median problem. The algorithm for knapsack median is based on a novel LP relaxation that constrains the set of centers that each vertex can get connected to. The rounding procedure uses a two-stage approach similar to that for matroid median.
A new synthetic approach to cyclic bis(3'->5')diguanylic acid (2003)

We developed a novel synthesis of biologically important cyclic bis(3'-->5')diguanylic acid (cGpGp). The present synthesis includes two strategies different from those employed in an existing synthesis. They are the phosphoramidite method for the preparation of a guanylyl(3'-->5')guanylic acid intermediate and allyl protection for guanine bases and internucleotide linkages. These distinctive strategies have allowed the new synthesis to provide the target compound in a higher yield than that of the existing synthesis.
Measurement of the decays B--> phiK and B--> phiK*. (2001)

We have observed the decays B--> phiK and phiK(*) in a sample of over 45 million B mesons collected with the BABAR detector at the PEP-II collider. The measured branching fractions are B(B+--> phiK+) = (7.7(+1.6)(-1.4)+/-0.8)x10(-6), B(B0--> phiK0) = (8.1(+3.1)(-2.5)+/-0.8)x10(-6), B(B+--> phiK(*+)) = (9.7(+4.2)(-3.4)+/-1.7)x10(-6), and B(B0--> phiK(*0)) = (8.7(+2.5)(-2.1)+/-1.1)x10(-6). We also report the upper limit B(B+--> phipi(+))<1.4x10(-6) ( 90% C.L.).
[Treatment of androgen-independent hormone refractory prostate cancer using docetaxel]. (2005)

Although prostate cancer patients with metastatic lesion initially respond to androgen ablation therapy, almost patients develop to hormone-refractory states. The optimal treatment for men with hormone refractory prostate cancer (HRPC) has not been established. Docetaxel is a semisynthetic taxane that inhibit tumor growth by induction of microtubule stabilization and promotion of bcl-2 inactivation, which induce apoptosis. Docetaxel as single agent has significant anti-tumor effect in HRPC patients. Docetaxel combined with estramustine or other antimicrotubular agents have shown further significant cytotoxicity in HRPC patients. In the United States, Food and Drug Administration (FDA) approved docetaxel, injection in combination with prednisone for the treatment of patients with advanced metastatic prostate cancer in 2004.
Supplementary Figure S3 from Bone Marrow–Derived Gr1<sup>+</sup> Cells Can Generate a Metastasis-Resistant Microenvironment Via Induced Secretion of Thrombospondin-1 (2023)

&lt;p&gt;Supplementary Figure S3 - PDF file 84K, Tsp-1 is specifically expressed by the BM-derived Gr1+ cell subsets&lt;/p&gt;
Reconstruction of dense point cloud from uncalibrated widebaseline images (2010)

This paper presents a new approach to reconstruct 3D dense point cloud from uncalibrated wide-baseline images. It includes three steps: acquiring quasi-dense point correspondences, recovering structure from motion, and reconstructing the 3D dense point cloud. We present a two level propagation algorithm. The first level is implemented in the 2D image space and the second level is in the 3D scene space. We use affine iterative model to acquire accurate quasi-dense correspondences, and iterative optimization to recover the camera parameters and the 3D scene structure. It increases the robust and accuracy of self-calibration. In the second level propagation, the strategy of view selection and local photometric consistency are used to minimize the effects of occlusions and highlights etc. We demonstrate our algorithm with some high-quality reconstruction examples.
Collecter, formaliser, qualifier et stocker les données pour gérer les patrimoines (2016)

Effective asset management strongly depends on the available data related to different fields: technical, environmental (in particular threats on the environment, assets and people), socio-economic and financial criteria. Different suitable modes of collection, formalization, qualification and storage must be implemented under strong regulatory constraints in some cases (Regulations for Safety of Hydraulic Structures, Decree concerning the Definition of a detailed description of the networks of public water and sanitation services, INSPIRE European Directive... ). The article offers a short review on current practices for these four tasks for different asset types. / Une gestion patrimoniale efficace des infrastructures dépend fortement de la disponibilité des données issues des domaines techniques, environnementaux, socio-économiques et financiers. Aussi, il est important de mettre en ½uvre plusieurs modes appropriés pour collecter, formaliser, qualifier et stocker ces données. Cet article propose un balayage des pratiques actuelles pour différents types de patrimoine.
The rate of contradictory lateralization of the epileptic seizure onset zone between ictal and interictal brain perfusion SPECT (2021)

Ziel/Aim Ictal and interictal brain perfusion SPECT are widely used for the identification of the seizure onset zone (SOZ) in presurgical evaluation of epilepsy patients. Ictal SPECT provides higher sensitivity for this task. Aim of this retrospective study was to estimate the rate of contradictory SOZ lateralization between ictal and interictal SPECT in a large clinical patient sample.
Comparison between symmetrical and asymmetrical partially shorted patch antennas (2000)

Symmetrical and asymmetrical partially shorted patch antennas are numerically studied using the finite-difference time-domain method. It is observed that the patch size of the asymmetrical partially shorted case can be reduced more than that of the symmetrical case, while the bandwidth of the former is less than that of the latter. © 2001 John Wiley & Sons, Inc. Microwave Opt Technol Lett 28: 214–216, 2001.
REPAIRtoire--a database of DNA repair pathways (2010)

REPAIRtoire is the first comprehensive database resource for systems biology of DNA damage and repair. The database collects and organizes the following types of information: (i) DNA damage linked to environmental mutagenic and cytotoxic agents, (ii) pathways comprising individual processes and enzymatic reactions involved in the removal of damage, (iii) proteins participating in DNA repair and (iv) diseases correlated with mutations in genes encoding DNA repair proteins. REPAIRtoire provides also links to publications and external databases. REPAIRtoire contains information about eight main DNA damage checkpoint, repair and tolerance pathways: DNA damage signaling, direct reversal repair, base excision repair, nucleotide excision repair, mismatch repair, homologous recombination repair, nonhomologous end-joining and translesion synthesis. The pathway/protein dataset is currently limited to three model organisms: Escherichia coli, Saccharomyces cerevisiae and Homo sapiens. The DNA repair and tolerance pathways are represented as graphs and in tabular form with descriptions of each repair step and corresponding proteins, and individual entries are cross-referenced to supporting literature and primary databases. REPAIRtoire can be queried by the name of pathway, protein, enzymatic complex, damage and disease. In addition, a tool for drawing custom DNA-protein complexes is available online. REPAIRtoire is freely available and can be accessed at http://repairtoire.genesilico.pl/.
IL-2-R beta expression and function within resting CD8+ T cells preferentially segregate with the CD45R0+ subset. (1992)

Human peripheral blood CD8+ T cells constitutively express a low level of IL-2-R beta chains which were shown in this study to be preferentially carried by the CD45R0+ subset. Such receptors can transduce signals for in vitro IL-2-induced cytolytic function and for the initiation of soluble anti-CD3 and IL-2-induced cell proliferation. Using these stimulation models, a comparison was made between the responsiveness of resting, small CD45R0+ and CD45RA+ subpopulations of CD8+ T cells, both of them being isolated by negative selection and rigorously depleted of monocytes and of IL-2-inducible non-MHC-restricted CTL. Strong proliferation was induced in CD8+/CD45R0+ cells in response to IL-2 and soluble anti-CD3 (each of these stimuli being by itself ineffective), while in contrast, CD8+/CD45RA+ cells manifested, in this system, little reactivity. Accordingly, no conversion to the CD45R0 phenotype occurred in single stained CD45RA+ T cells following their incubation with the stimuli. A similar restriction of reactivity to CD8+/CD45R0+ T cells was observed with respect to IL-2-induced targetable T cell cytotoxicity. The CTL activity induced by IL-2 alone occurred without cell division. In contrast, the additional increase in CTL activity occurring upon the synergistic actions of anti-CD3 mAb and IL-2 coincided with intense cell proliferation, with no generation of LAK activity. The inhibition exerted by anti-IL-2-R beta mAb in the cytolytic and the proliferative activities induced by these stimuli in resting CD8+/CD45R0+ T cells emphasizes the importance of constitutive IL-2-R beta chains in the biology of these cells.
Field Test Results of Additional Data Transmission for the ATSC Terrestrial DTV System (2014)

In this paper, we explain an additional data transmission (ADT) increasing the data capacity of the advanced television systems committee terrestrial digital television (DTV) system, present its field test results conducted in Jeju Island, Korea, and analyze the results in different scenarios. The ADT system can offer an additional data of rate from a few hundred bits per second (bps) to a few megabits per second based on a transmitter identification (TxID) or successive interference cancellation (SIC) techniques. For the field test, the field strength and the required carrier to noise ratio for a stable reception were measured at each test point. Based on the field test, we verify that the TxID- and SIC-based ADT systems can provide an additional data link supporting 160 bps data rate, which is at least 13 dB robust compared to the conventional DTV system, and 2 Mbps data rate which is about 3 dB worse than the conventional DTV system, respectively.