gebhart/patrepeval huggingface dataset:
Management of the depressive component of bipolar disorder (1996)

Acute bipolar depression (ABD) and breakthrough depression occurring during maintenance therapy of bipolar disorder are associated with significant morbidity and an increased risk of suicide. Lithium is an effective mood stabilizer for ABD, but its onset of antidepressant action is slow and additional antidepressant therapy is often prescribed. The extent to which other mood stabilizers (e.g., carbamazepine and valproate) have antidepressant activity is unclear. Preliminary initial research suggests three potential advantages that selective serotonin reuptake inhibitors have over tricyclic antidepressant for ABD: possibly greater efficacy, fewer adverse effects, and a lower frequency of antidepressant-induced mania. Bupropion may also have significant advantages. However, further research is needed to confirm these findings. Monoamine oxidase inhibitors are the antidepressant of choice for atypical bipolar depression. Electroconvulsive therapy (ECT) has the highest response rate of all treatments for ABD. Further research is needed to explore combination treatments with mood stabilizers and antidepressants for the effective treatment of ABD. Depression and Anxiety 4:190–198, 1996/1997. © 1997 Wiley-Liss, Inc.
Dual-Polarised Radiometer for Road Surface Characterisation (2022)

Abstract This paper presents measurements using a dual-polarised radiometer operating at 93 GHz to detect ice or water on asphalt in laboratory conditions. The brightness temperatures of both H and V polarizations were measured for a dry surface, liquid water, and ice on asphalt at observation angles of 50° and 56°. The results presented in this paper demonstrate that the studied road conditions can be identified by the radiometer. The measurements are compared with a model and surface parameters, such as dielectric constant and roughness are fitted and compared to reference values. The experiments and results, described in this article, are the first steps towards the future installation of a polarimetric sensor on a moving vehicle for traffic safety.
Fabrication of 2D arrays of multi-component nanoparticles (2014)

The paper presents a study of a physical method for fabrication of two-dimensional (2D) arrays composed of multi-component nanoparticles on a dielectric substrate. The method consists of two steps. In the first one, thin films composed of different metals are deposited by a classical PLD technique by using targets consisting of sections of different materials. Thin films composed of mixtures of different metals, as gold, silver, nickel, cobalt, iron, platinum, are thus deposited on a quartz substrate. By changing the area of the different sections in the target, thin films with different concentration of the metals are produced. The films fabricated are then annealed by nanosecond laser pulses delivered by a Nd:YAG laser system operating at its third harmonic. The modification of the films is studied as a function of the parameters of the incident radiation, as number of pulses and laser pulse fluence. It is found that the laser annealing can lead to a decomposition of the film into a monolayer of nanoparticles with a narrow size distribution. The optical properties of the structures produced are analyzed on the basis of their transmission spectra. The structures can be used in surface enhanced Raman spectroscopy (SERS) and magneto-optics.
A critical review of conceptual and empirical approaches to characterize infiltration (2022)

&amp;lt;p&amp;gt;Over the past two centuries,&amp;amp;#160;studying&amp;amp;#160;the infiltration process&amp;amp;#160;has received significant efforts resulting in&amp;amp;#160;numerous&amp;amp;#160;infiltration models being developed. These models depended&amp;amp;#160;on&amp;amp;#160;specific&amp;amp;#160;soil&amp;amp;#160;properties,&amp;amp;#160;and were influenced by&amp;amp;#160;initial and boundary conditions.&amp;amp;#160;They were also classified into&amp;amp;#160;two&amp;amp;#160;major&amp;amp;#160;categories: empirical and&amp;amp;#160;conceptual&amp;amp;#160;models,&amp;amp;#160;although the boundaries between those two categories can be debated for several models.&amp;amp;#160;The empirical models&amp;amp;#160;solved&amp;amp;#160;the infiltration problem&amp;amp;#160;by&amp;amp;#160;curve-fitting measured data&amp;amp;#160;into algebraic equations.&amp;amp;#160;In contrast, the conceptual approaches built&amp;amp;#160;on&amp;amp;#160;earlier concepts, mainly&amp;amp;#160;derived from&amp;amp;#160;the&amp;amp;#160;fundamental&amp;amp;#160;flow&amp;amp;#160;models,&amp;amp;#160;and then formulated analytical solutions applied&amp;amp;#160;to&amp;amp;#160;the infiltration problem.&amp;amp;#160;In this review, we&amp;amp;#160;create an inclusive&amp;amp;#160;survey&amp;amp;#160;covering&amp;amp;#160;the&amp;amp;#160;diverse&amp;amp;#160;spectrum of&amp;amp;#160;published infiltration modeling&amp;amp;#160;to&amp;amp;#160;understand&amp;amp;#160;the&amp;amp;#160;philosophy and&amp;amp;#160;evolution of&amp;amp;#160;those&amp;amp;#160;empirical&amp;amp;#160;and conceptual&amp;amp;#160;models&amp;amp;#160;across the years.&amp;amp;#160;After&amp;amp;#160;providing a full&amp;amp;#160;historical retrospective&amp;amp;#160;of&amp;amp;#160;infiltration models,&amp;amp;#160;we explored&amp;amp;#160;the model parameters&amp;amp;#160;and their evolution&amp;amp;#160;with time.&amp;amp;#160;We&amp;amp;#160;also&amp;amp;#160;reviewed&amp;amp;#160;the&amp;amp;#160;different&amp;amp;#160;methods&amp;amp;#160;applied to estimate&amp;amp;#160;the basic and common&amp;amp;#160;infiltration&amp;amp;#160;parameters, as well as&amp;amp;#160;the challenges&amp;amp;#160;that arise&amp;amp;#160;by such methods.&amp;lt;/p&amp;gt;
The Habitat Demonstration Unit System Integration (2010)

The Lunar Surface System Habitat Demonstration Unit (HDU) will require a project team to integrate a variety of contributions from National Aeronautics and Space Administration (NASA) centers and potential outside collaborators and poses a challenge in integrating these disparate efforts into a cohesive architecture. To accomplish the development of the first version of the HDU, the Pressurized Excursion Module (PEM), from conception in June 2009 to rollout for operations in July 2010, the HDU project team is using several strategies to mitigate risks and bring the separate efforts together. First, a set of design standards is being developed to define the interfaces between the various systems of PEM and to the payloads, such as the Geology Laboratory, that those systems will support. Scheduled activities such as early fit-checks and the utilization of a habitat avionics test bed prior to equipment installation into HDU PEM are planned to facilitate the integration process. A coordinated effort to establish simplified Computer Aided Design (CAD) standards and the utilization of a modeling and simulation systems will aid in design and integration concept development. Finally, decision processes on the shell development including the assembly sequence and the transportation have been fleshed out early on HDU design to maximize the efficiency of both integration and field operations.
Vulcanization of liquid carboxyl‐terminated rubber filled with leather buffing dust (1994)

Abstract Vulcanization of the system of liquid carboxyl‐terminated rubber–triepoxide–diisocyanate–chromium catalyst–leather buffing dust has been investigated. Using the method of statistical planning of experiments, regression equations were obtained, describing the effects of the components weight ratio on the vulcanization parameters and on the physical properties of the vulcanized rubber. © 1994 John Wiley &amp; Sons, Inc.
Implantable micro CMOS imaging devices for biomedical applications (2013)

This paper reviews recent advancement of micro CMOS imaging devices to measure brain neural activities in an un-tethered mouse. Three types of imaging devices have been developed: a fiber endoscope, a head-mountable imaging device, and a brain-implantable imaging device. Among them, a brain-implantable imaging device can realize to observe neural activity in deep brain regions of the brain, such as hippocampus. The detail device structure and characteristics are presented.
Supplementary Table from Targeting RAS Mutant Colorectal Cancer with Dual Inhibition of MEK and CDK4/6 (2023)

Supplementary Table from Targeting RAS Mutant Colorectal Cancer with Dual Inhibition of MEK and CDK4/6
Propagation and termination rate coefficients in N-vinylcarbazole free radical polymerization obtained via 440 nm pulsed laser and online 1H NMR kinetic experiments (2003)

Propagation rate coefficients, k(p), of N-vinylcarbazole in solution have been determined via visible light pulsed-laser polymerization over a wide temperature range (E-A = 25.3 +/- 5 kJ.mol(-1), A = 1.0 x 10(8) L.mol(-1).s(-1)). The k(p) data set was used to deduce (average) termination rate coefficients via H-1 NMR spectroscopic kinetic experiments and the corresponding Arrhenius parameters (E-A = -8.5 kJ.mol(-1) +/- 8 kJ.mol(-1)).
Combining naproxen and a dual amylin and calcitonin receptor agonist improves pain and structural outcomes in the collagen-induced arthritis rat model (2019)

This study demonstrates that combining KBP and naproxen may be a relevant therapeutic strategy for RA, resulting in improvements to the overall health, pain, inflammation, and joint structure.
A ligand-directed divergent catalytic approach to establish structural and functional scaffold diversity (2017)

The selective transformation of different starting materials by different metal catalysts under individually optimized reaction conditions to structurally different intermediates and products is a powerful approach to generate diverse molecular scaffolds. In a more unified albeit synthetically challenging strategy, common starting materials would be exposed to a common metal catalysis, leading to a common intermediate and giving rise to different scaffolds by tuning the reactivity of the metal catalyst through different ligands. Herein we present a ligand-directed synthesis approach for the gold(I)-catalysed cycloisomerization of oxindole-derived 1,6-enynes that affords distinct molecular scaffolds following different catalytic reaction pathways. Varying electronic properties and the steric demand of the gold(I) ligands steers the fate of a common intermediary gold carbene to selectively form spirooxindoles, quinolones or df-oxindoles. Investigation of a synthesized compound collection in cell-based assays delivers structurally novel, selective modulators of the Hedgehog and Wnt signalling pathways, autophagy and of cellular proliferation.
A new method for determining absorption cross sections out of initially excited vibrational states (2009)

A first experimental demonstration, combining the methods of vibrationally mediated photodissociation (VMP) and ionization-loss stimulated Raman spectroscopy (ILSRS) for measuring cross sections for dissociation of vibrationally excited levels is reported. The action spectrum obtained in the VMP of methylamine exhibits enhancement of the H photofragment yield as a result of initial vibrational excitation and the ILSRS monitors the fraction of molecules being excited. The partial cross sections for H production out of the sampled vibrational states and the extent of mode selectivity were thus determined.
Towards LIDAR-RADAR based Terrain Mapping for Traversability Analysis (2015)

International audience
A surprising mediator of oxidative DNA damage (2016)

KEYWORDS : cell deathchemotherapyDNA damagedsDNA breaksEndoplasmic Reticulum stressLeukotriene C4microsomal glutathione-S-transferase 2NADPH oxidase 4Oxidative stressreactive oxygen species
A halide-free route to groups 12 and 13 organometallic and metalloorganic complexes (1996)

Nucleophilic substitution of the bis(trimethylsilyl)amido groups of [M{N(SiMe3)2}2](M = Zn or Cd) and [In{N(SiMe3)2}3] was found to be a halide-free and homogeneous approach to organometallic and metalloorganic complexes. The breadth of this new synthetic approach is illustrated by the formation of [Cd(SCPh3)2(tmen)]1(tmen = Me2NCH2CH2NMe2), [(PhC≡C)4Zn{Li(tmen)}2]2 and [Li(thf)4][In(C≡CPh)4]3(thf = tetrahydrofuran) from nucleophilic substitution reactions utilising [M{N(SiMe3)2}2](M = Zn or Cd) and [In{N(SiMe3)2}3], the outcome of which is dependent upon the Lewis bases and nucleophiles employed and the metal centres concerned. The crystal structures of complexes 1–3 have been determined.
Epitopes on glycoprotein C of bovine herpesvirus-1 (BHV-1) that allow differentiation between BHV-1.1 and BHV-1.2 strains. (1999)

In cattle, bovine herpesvirus-1 (BHV-1) can cause a mild genital disease known as infectious pustular vulvovaginitis (IPV) and a more severe respiratory disease known as infectious bovine rhinotracheitis (IBR). On the basis of epidemiological data, it has been proposed that these diseases are caused by strains with different genotypes (IBR by BHV-1.1 and IPV by BHV-1.2 strains). By using a panel of 237 BHV-1 isolates, a monoclonal antibody (MAb 71) was found that failed to react with all 54 putative IPV strains in the panel, and another MAb (77) was found that did not react with 16 of these 54 IPV strains. Because MAbs 71 and 77 also failed to react with a BHV-1.1 glycoprotein C (gC)-deletion mutant, it was hypothesized that both MAbs recognize BHV-1.1 gC. By marker-rescue experiments and by expressing fragments of the BHV-1.1 gC gene in recombinant baculoviruses, it was shown that both MAbs indeed recognize BHV-1.1 gC. MAb 71 recognizes the N-terminal half and MAb 77 recognizes the C-terminal half of BHV-1.1 gC. In a PEPSCAN analysis with 12-mer oligopeptides, MAb 71 reacted with overlapping peptides containing gC amino acid residues 75-80 and MAb 77 did not react in this analysis. The differences in gC found in this study may contribute to the biological differences between BHV-1.1 and BHV-1.2.
Associations of C1q/TNF-Related Protein-9 Levels in Serum and Epicardial Adipose Tissue with Coronary Atherosclerosis in Humans (2015)

Circulating and coronary CTRP9 plays an important role in the inflammation and coronary atherosclerosis of CAD patients. Serum CTRP9 is an independent protective factor of CAD.
Significance of chromosome 1p loss of heterozygosity in neuroblastoma. (1995)

We analyzed 156 primary neuroblastoma tumor samples for loss of heterozygosity at the distal short arm of chromosome 1 (1p LOH). We also compared 1p LOH with known clinical and genetic prognostic variables as well as patient outcome. 1p LOH was detected in 30 of 156 tumors (19%) and was strongly associated with adverse clinical and biological features. 1p LOH was also strongly predictive of a poor outcome in univariate analyses (estimated 4-year survival, 32 +/- 10% SE versus 76 +/- 5% SE; P < 0.001). However, the prognostic value of 1p LOH was equivocal when stratified for amplification of the MYCN oncogene (P = 0.16). We conclude that 1p LOH is an important component of a pattern of genetic abnormalities in neuroblastoma associated with an aggressive clinical course.
Interleukin-1 accelerates autocrine growth of myeloma cells through interleukin-6 in human myeloma (1989)

Recombinant interleukin 1 alpha (rIL-1 alpha) augmented proliferation of freshly isolated myeloma cells as well as B-cell stimulatory factor 2 (BSF-2)/interleukin-6 (IL-6). Recombinant IL-1 alpha-induced proliferation was partially inhibited by anti-IL-6 antibody. In the culture supernatants of rIL-1 alpha-stimulated myeloma cells, IL-6 activities, which were measured by using an IL-6-dependent murine hybridoma clone, MH60.BSF2, were increased, when compared with those in the culture supernatants of nonstimulated myeloma cells. Furthermore, IL-6 messenger RNA (mRNA) expression was also augmented in IL-1 alpha- stimulated myeloma cells. Therefore rIL-1 alpha stimulates myeloma cells to produce IL-6, which consequently augments proliferation of myeloma cells. Thus, IL-1 can accelerate autocrine growth of myeloma cells through IL-6.
Changes in insulin and insulin signaling in Alzheimer’s disease: cause or consequence? (2016)

Individuals with type 2 diabetes have an increased risk for developing Alzheimer's disease (AD), although the causal relationship remains poorly understood. Alterations in insulin signaling (IS) are reported in the AD brain. Moreover, oligomers/fibrils of amyloid-β (Aβ) can lead to neuronal insulin resistance and intranasal insulin is being explored as a potential therapy for AD. Conversely, elevated insulin levels (ins) are found in AD patients and high insulin has been reported to increase Aβ levels and tau phosphorylation, which could exacerbate AD pathology. Herein, we explore whether changes in ins and IS are a cause or consequence of AD.
Silicon based modulators and systems for short reach interconnect (2012)

We discuss silicon based modulators and systems for short reach interconnect. An infrastructure based on integrating photonic devices with CMOS circuits provides a cost effective and low power solution for these applications.
Lipoprotein Uptake by Neuronal Growth Cones in Vitro (1987)

Macrophages that rapidly enter injured peripheral nerve synthesize and secrete large quantities of apolipoprotein E. This protein may be involved in the redistribution of lipid, including cholesterol released during degeneration, to the regenerating axons. To test this postulate, apolipoprotein E-associated lipid particles released from segments of injured rat sciatic nerve and apolipoprotein E-containing lipoproteins from plasma were used to determine whether sprouting neurites, specifically their growth cones, possessed lipoprotein receptors. Pheochromocytoma (PC12) cells, which can be stimulated to produce neurites in vitro, were used as a model system. Apolipoprotein E-containing lipid particles and lipoproteins, which had been labeled with fluorescent dye, were internalized by the neurites and their growth cones; the unmetabolized dye appeared to be localized to the lysosomes. The rapid rate of accumulation in the growth cones precludes the possibility of orthograde transport of the fluorescent particles from the PC12 cell bodies. Thus, receptor-mediated lipoprotein uptake is performed by the apolipoprotein B,E(LDL) (low density lipoprotein) receptors, and in the regenerating peripheral nerve apolipoprotein E may deliver lipids to the neurites and their growth cones for membrane biosynthesis.
A Study of Diesel Cold Starting using both Cycle Analysis and Multidimensional Calculations (1991)

&lt;div class="htmlview paragraph"&gt;The physical in-cylinder processes and ignition during cold starting have been studied using computational models, with particular attention to the influences of blowby, heat transfer during the compression stroke, spray development, vaporization and fuel/air mixture formation and ignition. Two different modeling approaches were used. A thermodynamic zero dimensional cycle analysis program in which the fuel injection effects were not modeled, was used to determine overall and gas exchange effects. The three-dimensional KIVA-II code was used to determine details of the closed cycle events, with modified atomization, blowby and spray/wall impingement models, and a simplified model for ignition. The calculations were used to obtain an understanding of the cold starting process and to identify practical methods for improving cold starting of direct injection diesel engines. It was found that, blowby gas flow represents an important source of reductions for the cylinder gas temperature at lower cranking speeds, opposing the squish flow. Overfueling and advanced injection increase the amount of fuel evaporated. The spray intact core is extended at low temperatures, spray wall impingement phenomena are characterized by low impact velocities and the bouncing of liquid drops enhances the limited fuel-air mixture formation. Failure to achieve successful ignition at low initial air temperatures was predicted by the simple kinetics model.&lt;/div&gt;
Chiroptical properties of binuclear rhodium complexes of lanostane alcohols (2001)

The circular dichroism (CD) of the in situ-formed Rh2(OCOCF3)4 complexes of sterically hindered, secondary lanostane alcohols was investigated. The main object of the present studies are derivatives of 3beta-, 7alpha-, 7beta-, and 11beta-hydroxylanostanes with or without an additional functional group, e.g., double bond, oxo-, hydroxy-, or acetoxy groups. Up to five Cotton effects (CEs) can be found in the CD spectra of Rh-complexes of these alcohols in the spectral range between 650-300 nm. Correlation of the CEs signs with the absolute stereochemistry at the carbon atom bearing the hydroxy group was investigated. The Rh-complex with the 3beta-acetoxylanostan-11beta-ol ligand was isolated in the crystalline form. Its polymeric structure, determined by the X-ray method, shows the di-Rh-units linked by the axially ligating oxygen atoms of the hydroxy and acetoxy groups. In the latter case, the coordination takes place through the carbonyl oxygen.
Studies on the effect of thiuram disulfide on NR vulcanization accelerated by thiazole‐based accelerator systems (1996)

Thiuram disulfides form synergistic combinations with thiazole and thiazole-based accelerators, namely, N-cyclohexy-2-benzothiazole sulfenamide (CBS), 2-mercaptobenzothiazole(MBT), and 2-mercaptobenzothiazyl disulfide (MBTS). Unfortunately, widely used thiuram disulfides (TD) generate carcinogenic N-nitrosoamine. It is reported that the nitrosamines from N-methylpiperazine and dibenzylamine are free from this menace. So, some investigations were carried out with the binary combinations of each of bis(N-methylpiperazino)thiuram disulfide (MPTD), tetrabenzylthiuram disulnde (TBzTD), and tetramethyl-thiuram disulfide (TMTD) separately with CBS, MBT, and MBTS. It was observed that all the TD are activated by the CBS, MBT, or MBTS in the combinations studied. The intensity of activation is manifested in the enhancement of torque, modulus, tensile strength, cure rate, hardness, and decrease of elongation at break values and is very much dependent upon the ratio of the accelerators used. Considering the torque, modulus, tensile strength, and the elongation at break values, it apears that MPTD and TBzTD are capable of competing with the hitherto unbeaten TMTD as suitable accelerators for the vulcanization of rubber. Some investigations in respect to heat- and age-resistance behavior have also been carried out and the observed differences in the activities of various binary combinations have been explained through a mechanism. The results obtained with filled vulcanizates indicate that the binary systems comprising TD and MBTS provide fruitful results of which the TBzTD–MBTS combination seems to give the best cure and physical data for practical vulcanizates. © 1996 John Wiley & Sons, Inc.
Supplementary Figures 1-9 from Hypoxia-Induced Autophagy Promotes Tumor Cell Survival and Adaptation to Antiangiogenic Treatment in Glioblastoma (2023)

&lt;p&gt;PDF file - 9.2MB&lt;/p&gt;
Driver's view and vehicle surround estimation using omnidirectional video stream (2004)

Our research is focused on the development of novel machine vision based telematic systems, which provide non-intrusive probing of the state of the driver and driving conditions. In this paper we present a system which allows simultaneous capture of the driver's head pose, driving view, and surroundings of the vehicle. The integrated machine vision system utilizes a video stream of full 360 degree panoramic field of view. The processing modules include perspective transformation, feature extraction, head detection, head pose estimation, driving view synthesis, and motion segmentation. The paper presents a multi-state statistical decision models with Kalman filtering based tracking for head pose detection and face orientation estimation. The basic feasibility and robustness of the approach is demonstrated with a series of systematic experimental studies.