gebhart/patrepeval huggingface dataset:
Cloning, amino acid sequence and tissue distribution of porcine thimet oligopeptidase (1994)

We have previously determined the amino acid sequence of porcine soluble angiotensin-binding protein (sABP) by cDNA cloning and sequencing. In this study, we have cloned a sABP homologue (PABH) from the same porcine cDNA libraries used for sABP cloning. PABH and sABP have 65% sequence identity. Sequence comparisons with other proteins revealed very high similarities between porcine PABH and rat thimet oligopeptidase (90%), and between porcine sABP and rabbit microsomal endopeptidase (93%). This suggests that PABH and thimet oligopeptidase are identical and that sABP and microsomal endopeptidase are also the same. Indeed, sABP was shown to have a peptidase activity that is sensitive to the metal-chelating agents EDTA and 1,10-phenanthroline; sABP was also sensitive to the thiol reagent p-chloromercuriphenylsulfonic acid. RNase-protection assays, using RNA preparations from various porcine tissues, indicated that thimet oligopeptidase mRNA is ubiquitously expressed whereas sABP mRNA is predominantly expressed in the liver, kidney and adrenal gland. This assay also revealed tissue-specific alternative splicing of the sABP-encoding message.
Low Leakage Clock Tree With Dual-Threshold- Voltage Split Input–Output Repeaters (2019)

Leakage power consumption of clock distribution networks (CDNs) is an important challenge in modern synchronous integrated circuits with billions of deeply scaled transistors. Multithreshold CMOS technology is commonly used to provide power reduction in standby mode while maintaining high performance in active mode. In this paper, a novel dual-threshold-voltage repeater circuit with split inputs-outputs (SPLIT-IOs) is employed for suppressing leakage currents in gated CDNs. Three floor planning strategies are considered for clock distribution across the chip with signal transition times of less than or equal to 50 ps at the leaves. Depending on the power supply voltage and floor plan, the standby leakage power consumption is reduced by 50.36%-78.43% with the proposed clock tree with SPLIT-IO repeaters as compared to the conventional three-level H-tree in a 45-nm CMOS technology. The spread of standby leakage power due to process variations is compressed by 36.72%-73.77% with the proposed clock tree as compared to the standard network. The proposed circuit technique significantly lowers the total energy consumption of partially active networks with local clock gating as well. The energy savings provided by the SPLIT-IO buffers are enhanced with the scaling of power supply voltage and frequency in synchronous systems-on-chip.
Innovations in phase 1 trial design: where do we go next? (2000)

In this issue of Clinical Cancer Research , Dees et al. [(1)][1] describe the use of PGDE[2][2] [(2)][3] in a Phase 1 trial of CI-958. PGDE was proposed [(2][3] [, 3)][4] as a more informative and efficient alternative to the standard design for Phase 1 studies (“modified Fibonacci”). Compared
Virulence profiles and other biological characters in water isolated Aeromonas hydrophila. (2000)

Thirty water isolates of A. hydrophila were tested for potential virulence profiles, antibiotic resistance and Bacteriocin-Like Substances (BLS) production. Cytotoxic activity was present in all strains tested, 87% were hemolytic and 70% adhesive. Lysine decarboxylase reactions (LDC) positivity was correlated with virulence factors: 100% versus cytotoxicity, 84% versus adherence, 76% versus hemolytic activity. The correlation was also present in the LDC-negative strains. Hemolytic and cytotoxic activities were frequently associated: high cytotoxicity, corresponding to high hemolytic activity and vice versa. The in vitro susceptibility of A. hydrophila to 28 antibacterial agents showed that cefotaxime was the most active beta-lactam antibiotic, and Cefuroxime inhibited 90% of the strains. Isolates were resistant to Penicillin G, Ampicillin, Carbenicillin, Amoxicillin, Cephalotin and Cefaclor. Tetracycline, Chloramphenicol, Nitrofurantoine, the quinolones and the aminoglycosides (except Streptomycin) were consistently active. BLS production never emerged against closely-related microorganisms. On the contrary A. hydrophila presented a heteroinhibitory activity against non-taxonomically related genera such as Listeria spp. (L. seeligeri NCTC 11856, L. welshimeri NCTC 11857, L. ivanovii NCTC 11846) and S. aureus ATCC 25923. Although a large number of strains showed virulence determinants together with other biological characters such as antibiotic resistance and BLS production, it was not possible to relate these factors to the observed plasmids.
Energy Cost Models of Smartphones for Task Offloading to the Cloud (2015)

Task offloading from smartphones to the cloud is a promising strategy to enhance the computing capability of smartphones and prolong their battery life. However, task offloading introduces a communication cost for those devices. Therefore, the consideration of the communication cost is crucial for the effectiveness of task offloading. To make task offloading beneficial, one of the challenges is to estimate the energy consumed in communication activities of task offloading. Accurate energy estimation models will enable these devices to make the right decisions as to whether or not to perform task offloading, based on the energy cost of the communication activities. Simply put, if the offloading process consumes less energy than processing the task on the device itself, then the task is offloaded to the cloud. To design an energy-aware offloading strategy, we develop energy models of the WLAN, third-generation, and fourth-generation interfaces of smartphones. These models make smartphones capable of accurately estimating the energy cost of task offloading. We validate the models by conducting an extensive set of experiments on five smartphones from different vendors. The experimental results show that our estimation models accurately estimate the energy required to offload tasks.
A Set of Nonpolar Thymidine Nucleoside Analogues with Gradually Increasing Size (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Quantum Tunneling Creates Fast Lane For Wireless [News] (2007)

A new dark-horse candidate has emerged that claims to be able to make cheap 60-GHz technology without using any semiconductor materials. It uses a proprietary mix of insulators and metals to achieve quantum tunneling, which lets electrons zip through devices in mere trillionths of a second.
Detection of an HLA‐DPw1‐associated epitope by an alloreactive T cell clone (1987)

An alloreactive T cell clone was generated using HLA-A, B, C, DR, DQ, D identical, but HLA-DP different homozygous typing cells as responder and stimulator. The alloproliferative and -cytotoxic clone appears to recognize an epitope associated with HLA-DPw1.
Kinetic Analysis of Strains of Lactic Acid Bacteria and Acetic Acid Bacteria in Cocoa Pulp Simulation Media toward Development of a Starter Culture for Cocoa Bean Fermentation (2010)

The composition of cocoa pulp simulation media (PSM) was optimized with species-specific strains of lactic acid bacteria (PSM-LAB) and acetic acid bacteria (PSM-AAB). Also, laboratory fermentations were carried out in PSM to investigate growth and metabolite production of strains of Lactobacillus plantarum and Lactobacillus fermentum and of Acetobacter pasteurianus isolated from Ghanaian cocoa bean heap fermentations, in view of the development of a defined starter culture. In a first step, a selection of strains was made out of a pool of strains of these LAB and AAB species, obtained from previous studies, based on their fermentation kinetics in PSM. Also, various concentrations of citric acid in the presence of glucose and/or fructose (PSM-LAB) and of lactic acid in the presence of ethanol (PSM-AAB) were tested. These data could explain the competitiveness of particular cocoa-specific strains, namely, L. plantarum 80 (homolactic and acid tolerant), L. fermentum 222 (heterolactic, citric acid fermenting, mannitol producing, and less acid tolerant), and A. pasteurianus 386B (ethanol and lactic acid oxidizing, acetic acid overoxidizing, acid tolerant, and moderately heat tolerant), during the natural cocoa bean fermentation process. For instance, it turned out that the capacity to use citric acid, which was exhibited by L. fermentum 222, is of the utmost importance. Also, the formation of mannitol was dependent not only on the LAB strain but also on environmental conditions. A mixture of L. plantarum 80, L. fermentum 222, and A. pasteurianus 386B can now be considered a mixed-strain starter culture for better controlled and more reliable cocoa bean fermentation processes.
Developmental expression of two murine fibroblast growth factor receptors, fig and bek (1991)

Developmental expression of two closely related fibroblast growth factor receptors, bek and flg, is described from early postimplantation until advanced organogenesis. Transcripts of bek and flg were first seen in the primitive ectoderm of egg-cylinder-stage embryos. Later, starting with somitogenesis, and then throughout embryogenesis, they were actively transcribed both in the mesoderm and neuroectoderm. Bek was expressed also in the surface ectoderm and in various epithelia, whereas flg expression was restricted mainly to the mesenchyme. In the limb bud bek transcripts displayed a gradient-like distribution and appeared earlier than flg. The two receptors, in contrast to their almost identical ligand binding specificity, displayed distinct spatial specificities throughout development, suggesting that developmental localization may contribute to functional specificity. The role of bek and flg in gastrulation and in epithelial-mesenchymal interactions of organogenesis will be discussed.
Morphological Variations of Explosive Residue Particles and Implications for Understanding Detonation Mechanisms (2016)

The possibility of recovering undetonated explosive residues following detonation events is well-known; however, the morphology and chemical identity of these condensed phase postblast particles remains undetermined. An understanding of the postblast explosive particle morphology would provide vital information during forensic examinations, allowing rapid initial indication of the explosive material to be microscopically determined prior to any chemical analyses and thereby saving time and resources at the crucial stage of an investigation. In this study, condensed phase particles collected from around the detonations of aluminized ammonium nitrate and RDX-based explosive charges were collected in a novel manner utilizing SEM stubs. By incorporating the use of a focused ion beam during analysis, for the first time it is possible to determine that such particles have characteristic shapes, sizes, and internal structures depending on the explosive and the distance from the detonation at which the particles are recovered. Spheroidal particles (10-210 μm) with microsurface features recovered following inorganic charge detonations were dissimilar to the irregularly shaped particles (5-100 μm) recovered following organic charge firings. Confirmatory analysis to conclude that the particles were indeed explosive included HPLC-MS, Raman spectroscopy, and mega-electron volt-secondary ionization mass spectrometry. These results may impact not only forensic investigations but also the theoretical constructs that govern detonation theory by indicating the potential mechanisms by which these particles survive and how they vary between the different explosive types.
Diffractive elements for imaging with extended depth of focus (2005)

We present the abilities of diffractive elements for imaging with extended depth of focus. The elements of interest belong to the class of diffractive structures focusing incident light into a segment of the optical axis. We describe the imaging properties of the two following elements of this kind: the annular axicon and the light sword optical element (LSOE). In particular, the point spread functions and the modulation transfer functions of axicons and LSOEs are analyzed experimentally and numerically in detail. The obtained results correspond to different defocusing parameters. The performed experiments confirm the usefulness of axicons and LSOEs for imaging with extended depth of focus.
Pharmacokinetics of buprenorphine following intravenous administration in dogs (2008)

Pharmacokinetic variables of buprenorphine reported here differed from those previously reported for dogs. Wide variations in individual t(1/2) values suggested that dosing intervals be based on assessment of pain status rather than prescribed dosing intervals.
Spatio-temporal edge-based median filtering for deinterlacing (2002)

In this paper, we propose a new computationally efficient deinterlacing algorithm which shows effective visual performance. In the proposed scheme, correlation dependent interpolation and line doubling schemes are utilized separately for the low frequency and high frequency components of the 2-D input signal. Computer simulation results indicate that the proposed algorithm shows better visual performance than conventional deinterlacing algorithms.
Controlling Separation in Turbomachines (2010)

Four examples of flow control: 1) Passive control of LP turbine blades (Laminar separation control). 2) Aspiration of a conventional axial compressor blade (Turbulent separation control). 3) Compressor blade designed for aspiration (Turbulent separation control). 4.Control of intakes in crosswinds (Turbulent separation control).
Palmitoyl protein thioesterase-1 deficiency impairs synaptic vesicle recycling at nerve terminals, contributing to neuropathology in humans and mice (2008)

Neuronal ceroid lipofuscinoses represent the most common childhood neurodegenerative storage disorders. Infantile neuronal ceroid lipofuscinosis (INCL) is caused by palmitoyl protein thioesterase-1 (PPT1) deficiency. Although INCL patients show signs of abnormal neurotransmission, manifested by myoclonus and seizures, the molecular mechanisms by which PPT1 deficiency causes this abnormality remain obscure. Neurotransmission relies on repeated cycles of exo- and endocytosis of the synaptic vesicles (SVs), in which several palmitoylated proteins play critical roles. These proteins facilitate membrane fusion, which is required for neurotransmitter exocytosis, recycling of the fused SV membrane components, and regeneration of fresh vesicles. However, palmitoylated proteins require depalmitoylation for recycling. Using postmortem brain tissues from an INCL patient and tissue from the PPT1-knockout (PPT1-KO) mice that mimic INCL, we report here that PPT1 deficiency caused persistent membrane anchorage of the palmitoylated SV proteins, which hindered the recycling of the vesicle components that normally fuse with the presynaptic plasma membrane during SV exocytosis. Thus, the regeneration of fresh SVs, essential for maintaining the SV pool size at the synapses, was impaired, leading to a progressive loss of readily releasable SVs and abnormal neurotransmission. This abnormality may contribute to INCL neuropathology.
Metabolomics Reveal Induction of ROS Production and Glycosylation Events in Wheat Upon Exposure to the Green Leaf Volatile Z-3-Hexenyl Acetate (2020)

The activation and priming of plant defense upon perception of green leaf volatiles (GLVs) have often been reported. However, information as to which metabolic pathways in plants are affected by GLVs remains elusive. We report the production of reactive oxygen species in the tip of young wheat leaves followed by activation of antioxidant-related enzyme activity. In this study, we aimed to uncover metabolic signatures upon exposure to the GLV Z-3-hexenyl acetate (Z-3-HAC). By using an untargeted metabolomics approach, we observed changes in the phenylpropanoid pathways which yield metabolites that are involved in many anti-oxidative processes. Furthermore, exposure to GLV, followed by infection with <i>Fusarium graminearum</i> (Fg), induced significantly greater changes in the phenylpropanoid pathway compared to a sole Z-3-HAC treatment. Fragmentation of a selection of metabolites, which are significantly more upregulated in the Z-3-HAC + Fg treatment, showed D-glucose to be present as a substructure. This suggests that Z-3-HAC induces early glycosylation processes in plants. Additionally, we identified the presence of hexenyl diglycosides, which indicates that aerial Z-3-HAC is metabolized in the leaves by glycosyltransferases. Together these data indicate that GLV Z-3-HAC is taken up by leaves and incites oxidative stress. This subsequently results in the modulation of the phenylpropanoid pathway and an induction of glycosylation processes.
Autonomic Dysfunction and New‐Onset Atrial Fibrillation in Patients With Left Ventricular Systolic Dysfunction After Acute Myocardial Infarction: A CARISMA Substudy (2010)

Abnormal HRV and HRT parameters, which are associated with disturbances in the cardiac autonomic regulation, are associated with increased risk of new-onset AF independently of conventional clinical risk variables.
Antroquinonol A: Scalable Synthesis and Preclinical Biology of a Phase 2 Drug Candidate (2015)

The fungal-derived Taiwanese natural product antroquinonol A has attracted both academic and commercial interest due to its reported exciting biological properties. This reduced quinone is currently in phase II trials (USA and Taiwan) for the treatment of non-small-cell lung carcinoma (NSCLC) and was recently granted orphan drug status by the FDA for the treatment of pancreatic cancer and acute myeloid leukemia. Pending successful completion of human clinical trials, antroquinonol is expected to be commercialized under the trade name Hocena. A synthesis-enabled biological re-examination of this promising natural product, however, reveals minimal in vitro and in vivo antitumor activity in preclinical models.
Asymmetric Hydrogenation of 2-Benzylidenesuccinic Acid 4-[(4-BOC-amino)-1-piperidide] Monoamide: Key Step in a Process for Large Scale Preparation of a Renin Inhibitor (1994)

The N-terminal component 4 of an orally active renin inhibitor is prepared on kg-scale by asymmetric hydrogenation of the title compound 3. Enantioselectivities of several homogeneous homochiral rhodium(I)- and ruthenium(II)-diphosphine catalysts are compared.
Preparation of Hierarchical BiOBr Microspheres for Visible Light-Induced Photocatalytic Detoxification and Disinfection (2016)

Photocatalytic degradation is a promising alternative to traditional wastewater treatment methods. Recently developed visible light-responsive photocatalyst, BiOBr, has attracted extensive attentions. Hereby, a detailed investigation of application of BiOBr to bacterial inactivation and organic pollutants degradation is reported. Hydrothermal catalyst was prepared using template-free method. While, for solvothermal synthesis, CTAB was used as a template. Results indicate a higher photocatalytic activity by the solvothermally prepared catalyst. Solvothermally prepared BiOBr exhibited high photocatalytic activities in both water detoxification and disinfection.
Advances and Breakthroughs in Diffusers for Compressors and Pumps: A Short History of Diffusers for Centrifugal Machines (2018)

Abstract The diffuser plays an indispensable role in setting the useable flow range and efficiency for centrifugal machinery. Key aspects of the history and design of such diffusers are overviewed followed by a look at current, novel ideas for better systems. Improved machinery can be expected in the coming years due to decades of development work in this field.
Microwave characterization of vertically aligned multiwalled carbon nanotube arrays (2011)

Vertically aligned multiwalled carbon nanotube (VACNT) films have been characterized by rectangular waveguide measurements. The complex scattering parameters (S-parameters) are measured by a vector network analyzer at X-band frequencies. The effective complex permittivity and permeability of the VACNT films have been extracted. The extracted parameters are verified by full wave simulations and very good agreement has been obtained. The results of the systematic error analysis are presented and the errors are within the acceptable range. The performance of VACNT films as an absorber is examined, and comparison with the conventional carbon loaded materials shows that a 90% size reduction is possible while maintaining the same absorption level.
Linear mitochondrial DNA is rapidly degraded by components of the replication machinery (2018)

Emerging gene therapy approaches that aim to eliminate pathogenic mutations of mitochondrial DNA (mtDNA) rely on efficient degradation of linearized mtDNA, but the enzymatic machinery performing this task is presently unknown. Here, we show that, in cellular models of restriction endonuclease-induced mtDNA double-strand breaks, linear mtDNA is eliminated within hours by exonucleolytic activities. Inactivation of the mitochondrial 5'-3'exonuclease MGME1, elimination of the 3'-5'exonuclease activity of the mitochondrial DNA polymerase POLG by introducing the p.D274A mutation, or knockdown of the mitochondrial DNA helicase TWNK leads to severe impediment of mtDNA degradation. We do not observe similar effects when inactivating other known mitochondrial nucleases (EXOG, APEX2, ENDOG, FEN1, DNA2, MRE11, or RBBP8). Our data suggest that rapid degradation of linearized mtDNA is performed by the same machinery that is responsible for mtDNA replication, thus proposing novel roles for the participating enzymes POLG, TWNK, and MGME1.
Feasibility study on real-time seafloor glove monitoring cable-network-power feeding system (2003)

The concept of a next generation scientific cable network surrounding the Japanese Islands is presented. The proposed cable network has the following outstanding features: (1) continuous monitoring and power feeding, (2) covering interdisciplinary fields, (3) mesh-like cable configuration surrounding the Japanese Islands, (4) 20-50 km observatory intervals, (5) plural sensors connected in each observatory, (6) exchangeability of sensors for maintenance and replacement, (7) robustness against faults, (8) high cost performance. This paper mainly discusses the concept of the cable network and the power feeding system.
DENİZLİ BELEDİYESİ KENT BİLGİ SİSTEMİ TASARIMI VE FAYDA/MALİYET ANALİZİ (2013)

Kentsel alanlarda yerel yönetimler tarafından yürütülen teknik hizmetler açısından, mevcut yazılı belgelere ilave olarak güncel harita tabanlı konumsal bilgilere de hızlı bir şekilde erişim büyük önem taşımaktadır. Bu anlamda Kent Bilgi Sistemleri (KBS) teknolojisi kentsel yönetimler için etkin bir karar-destek aracıdır. KBS, yerel yönetimlerin ihtiyaç duyduğu, kent kapsamındaki her türlü grafik ve öznitelik bilgiyi organize eden ve yöneten konumsal tabanlı bir bilgi sistemidir. Yapılan çalışmada Denizli Belediyesi için KBS tasarımı yapılmış, tasarımda; proje planlaması, yazılım ve donanım seçimi, veri tabanı tasarımı, veri toplama, veri depolama, sistemin test edilmesi gibi aşamalardan geçilerek fayda, harcama kalemleri ile fayda-maliyet analizi sonuçları somut olarak çıkarılmıştır.