gebhart/patrepeval huggingface dataset:
Bioaccessibility of PAHs in Fuel Soot Assessed by an in Vitro Digestive Model with Absorptive Sink: Effect of Food Ingestion (2015)

We investigated the effects of changing physiological conditions in the digestive tract expected with food ingestion on the apparent bioaccessibility (Bapp) of 11 polycyclic aromatic hydrocarbons (PAHs) in a fuel soot. A previously established in vitro digestive model was applied that included silicone sheet as a third-phase absorptive sink simulating passive transfer of PAHs to intestinal epithelium in the small intestine stage. The Bapp is defined as the fraction found in the digestive fluid plus sheet after digestion. We determined that Bapp was independent of gastric pH and addition of nonlipid milk representing dietary proteins and carbohydrates, whereas it increased with bile acids concentration (2.0-10 g/L), small intestinal pH (5.00-7.35), and addition of soybean oil representing dietary lipid (100% and 200% of the mean daily ingestion by 2-5 year olds in the U.S.). Bapp of PAHs increases with small intestinal pH due to the combined effects of mass transfer promotion from nonlabile to labile sorbed states in the soot, weaker sorption of the labile state, and increasingly favorable partitioning from the digestive fluid to the silicone sink. Under fed conditions, Bapp increases with inclusion of lipids due to the combined effects of mass transfer promotion from nonlabile to labile states, and increasingly favorable partitioning into bile acid micelles. Our results indicate significant variability in soot PAH bioaccessibility within the range of physiological conditions experienced by humans, and suggest that bioaccessibility will increase with coconsumption of food, especially food with high fat content.
Control-to-output transfer function of peak current-mode controlled PWM DC–DC boost converter in CCM (2011)

A block diagram to derive the control-to-output transfer function of peak current-mode controlled pulse-width modulated (PWM) DC–DC boost power converter for continuous conduction mode (CCM) is presented. The control-to-output transfer function is derived and illustrated using MATLAB. The results obtained are required to design the compensator for the outer-voltage loop.
Hexapod Pilot Tests Determine the Influence of 3D Motions on the Performance of an Amine-Based Acid Gas Removal Unit Installed on a Floating Support (2016)

Abstract The objective of this paper is to present new improvements in the knowledge of the performance of an Acid Gas Removal Unit (AGRU) installed on a floating gas production facility, thanks to a R&amp;D program testing the influence of 3D motions and accelerations. The accurate design of the Acid Gas Removal Unit has a great importance for the profitability and success of a FLNG project. In order to limit both weight and footprint, it shall rely on the lowest possible solvent flowrate and on the minimal and optimum equipment size to treat the feed gas while taking into account motions of the floating support. The proposed paper will demonstrate how a tight but safe design of an amine unit can be proposed thanks to the results of an extensive experimental program. Total, Prosernat and IFPEN have conducted a four-year R&amp;D program at Heriot-Watt University based on pilot tests aiming at modelization of mass transfer and hydraulics of tilting and moving towers. This program has included the testing of multiple parameters such as liquid/gas flowrates, liquid viscosity, diameter of towers, height of packing beds, packing efficiency. This has been done under various conditions: static tilt, pitch and 3D motions generated by a hexapod robot with six degrees of freedom. The motion conditions tested were similar to those experienced by a column installed on a floating gas production support or on a FLNG. The collected information on hydraulics and mass transfer showed a significant impact of motions on liquid and gas distribution along the packing beds that can, under conditions of loads of gas and liquids, lead to a significant loss of absorption performances. An in-depth analysis of the large experimental data set with a comprehensive understanding of the phenomena in place allowed the development team to propose a robust model. This model is now embedded in a rated base mass transfer proprietary simulator of AGRU that can predict with good accuracy the impact of motions of the floating support on the performance of the unit. This paper will present key results accumulated along the program about the impact of motions on liquid/gas maldistribution along a packing bed. It will explain how the accumulated knowledge enables to size tight but reliable AGRU's for installation on a floating support, in the presence of CO2, but also of other contaminants like H2S. The discussion will be supported by comprehensive examples of degradation of the absorption performances on real cases affected by sea motion.
A Bioengineered Neuregulin-Hydrogel Therapy Reduces Scar Size and Enhances Post-Infarct Ventricular Contractility in an Ovine Large Animal Model (2020)

The clinical efficacy of neuregulin (NRG) in the treatment of heart failure is hindered by off-target exposure due to systemic delivery. We previously encapsulated neuregulin in a hydrogel (HG) for targeted and sustained myocardial delivery, demonstrating significant induction of cardiomyocyte proliferation and preservation of post-infarct cardiac function in a murine myocardial infarction (MI) model. Here, we performed a focused evaluation of our hydrogel-encapsulated neuregulin (NRG-HG) therapy's potential to enhance cardiac function in an ovine large animal MI model. Adult male Dorset sheep (<i>n</i> = 21) underwent surgical induction of MI by coronary artery ligation. The sheep were randomized to receive an intramyocardial injection of saline, HG only, NRG only, or NRG-HG circumferentially around the infarct borderzone. Eight weeks after MI, closed-chest intracardiac pressure-volume hemodynamics were assessed, followed by heart explant for infarct size analysis. Compared to each of the control groups, NRG-HG significantly augmented left ventricular ejection fraction (<i>p</i> = 0.006) and contractility based on the slope of the end-systolic pressure-volume relationship (<i>p</i> = 0.006). NRG-HG also significantly reduced infarct scar size (<i>p</i> = 0.002). Overall, using a bioengineered hydrogel delivery system, a one-time dose of NRG delivered intramyocardially to the infarct borderzone at the time of MI in adult sheep significantly reduces scar size and enhances ventricular contractility at 8 weeks after MI.
Chemistry of Crystalline Aluminosilicates. III. The Synthesis and Properties of Zeolite ZK-5 (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry of Crystalline Aluminosilicates. III. The Synthesis and Properties of Zeolite ZK-5George T. KerrCite this: Inorg. Chem. 1966, 5, 9, 1539–1541Publication Date (Print):September 1, 1966Publication History Published online1 May 2002Published inissue 1 September 1966https://pubs.acs.org/doi/10.1021/ic50043a016https://doi.org/10.1021/ic50043a016research-articleACS PublicationsRequest reuse permissionsArticle Views424Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An interrogating circuit and device for magnetostrictive biosensors (2016)

High performance biosensors for the detection of bacterial in various media have been developed using magnetostrictive/magnetoelastic resonators (MSRs). An MSR is a strip of magnetostrictive alloy coated with biological molecular recognition unit, such as antibody and phage. The sensor is based on the change in its resonant frequency. Therefore, it is critical to determine the resonant frequency of an MSR. The MSR biosensors have been developed for the detection of various pathogenic bacteria in liquid food and on the surface of fresh produce in real-time and in-situ manner. However, the instruments used to determine the resonant frequency of these sensors are bulky and expensive. Here an inexpensive circuit is developed to characterize the resonant frequency of the MRS sensors. The unique circuit design makes it is possible to have a real handheld device for the interrogation of MRS sensors. Additionally, a new methodology to enhance the signal is also introduced.
A University-Wide Compost Facility: Second-year Summary (2011)

The University Compost Facility opened late in 2008 and now has completed two full years of operation. This report is for the 12-month period of November 1, 2009 through October 31, 2010. The facility receives manure and biomass from several ISU facilities: the Dairy Farm, Animal Science Teaching Farms, including the horse barns, Campus Services (yard and greenhouse waste), ISU Dining (food waste), Ag Engineering/Agronomy Farm, BioCentury Research Farm, Plant Introduction Station, Reiman Gardens, Horticulture Station, and others. A total of 8,245 tons were received in the 12-month period (Table 1). About 77% of the incoming material came from the Dairy Farm. The facility generated compost and amended soil primarily for campus use. A total of 5,495 tons was outgoing from the facility (Table 1), of which 2,234 tons was low quality compost or manure that was applied to cropland in spring 2010. The severe winter prevented this material from composting completely. The primary product of the facility was amended soil; approximately 2,751 tons of amended soil was generated. Amended soil is a blend of compost, soil and sand. The ISU Compost Facility continues to serve a unique and vital role in assisting ISU be “greener” and more sustainable. The staff continues to learn how to improve the management of the compost to benefit the university.
Phytochemical screening and antimicrobial activities of Costus speciosus and Sea Qust (2017)

The present work reveals the preliminary phytochemical screening and the study of antimicrobial activities of Costus speciosus (Koen) and Sea Qust. These are medicinal plants of considerable importance. Carbohydrates, Tannins, Steroids, Anthocyanates and Proteins were detected in both plants. Alkaloids, saponines, Anthraquinones were present in Costus speciosus but where absent in Sea Qust. The antibacterial and antifungal activity of essential oils and plant extracts of Costus Speciosus and Sea Qust was investigated against a few pathogens viz. M. gypseum, M. canis, C. albicans and C. tropicalis, P. aeruginosa and S. aureus, P. aeruginosa and St. aureus. The data obtained validated their wide application for therapeutic purposes in alternative therapy.
[Autologous transplantation of Ph-negative peripheral blood stem cells for treatment of chronic myelogenous leukemia]. (2000)

A 21-year-old man, diagnosed in March 1997 as having chronic myelogenous leukemia (CML), received hydroxyurea followed by daily interferon (IFN) until December 1998, when the additional chromosome abnormality of +8 appeared. As no suitable matched donor was available, the patient received mobilization therapy consisting of mini-ICE (idarubicin, cytarabine, etoposide) followed by G-CSF subcutaneously. During hematopoietic recovery, a total of 12 x 10(6)/kg CD34-positive cells were harvested. Cytogenetic analysis of peripheral blood stem cell (PBSC) products using FISH revealed 1% BCR/ABL fusion signals. In March 1999, he received conditioning therapy consisting of busulfan (16 mg/kg) and cyclophosphamide (120 mg/kg) followed by infusion of 5 x 10(6)/kg CD34-positive cells. A neutrophil count of 500/microliter and a platelet count of 5 x 10(4)/microliter were attained by days 20 and 38, respectively. Bone marrow aspirates showed 2.6% BCR/ABL fusion signals on day 35 after autologous PBSC transplantation, and the patient remained in chronic phase until the sixth month, when a cytogenetic relapse (Ph, +8:4/20) occurred. These observations suggest that Ph-negative progenitor cells can be harvested using a mini-ICE regimen followed by G-CSF, and that autologous PBSC transplantation is feasible in patients with CML resistant to IFN.
Synthetic H. influenzae Vaccine Looks Good (2004)

Highly successful vaccines against Haemophilus influenzae type B (Hib) have been constructed using the capsular polysaccharide, purified from batch cultures. Now, scientists in Cuba and Canada have developed and tested a vaccine that contains a synthetic Hib antigen.

The researchers developed a technique for the efficient high-capacity synthesis of …
Probabilities and trajectories in a classical wave-particle duality (2012)

Several recent experiments were devoted to walkers, structures that associate a droplet bouncing on a vibrated liquid with the surface waves it excites. They reveal that a form of wave-particle duality exists in this classical system with the emergence of quantum-like behaviours. Here we revisit the single particle diffraction experiment and show the coexistence of two waves. The measured probability distributions are ruled by the diffraction of a quantumlike probability wave. But the observation of a single walker reveals that the droplet is driven by a pilot wave of different spatial structure that determines its trajectory in real space. The existence of two waves of these types had been proposed by de Broglie in his "double solution" model of quantum mechanics. A difference with the latter is that the pilot-wave is, in our experiment, endowed with a "path memory". When intrusive measurements are performed, this memory effect induces transient chaotic individual trajectories that generate the resulting statistical behaviour.
Electro-optic liquid crystal device employing two-dimensional WSe2 as the planar-alignment layers (2020)

Two-dimensional (2D) tungsten diselenide (WSe 2 ) nanosheets were transferred onto indium tin oxide (ITO) coated glass slides. Two such 2D WSe 2 -covered ITO glass slides were placed together to fabricate an electro-optic liquid crystal (LC) cell. A nematic LC inside this WSe 2 -based device obtains uniform planar-alignment. The coherent overlay of the LC molecules along the armchair direction on the WSe 2 lattice leads to this planar-alignment at the molecular scale. This WSe 2 -based LC device exhibits the typical electro-optical effect on the application of an electric field. A sharp Fréedericksz transition of the nematic director from this electro-optical effect confirms that the 2D WSe 2 provides sufficient planar anchoring energy in the device. Finally, the WSe 2 /ITO slide exhibits more optical transparency than a standard polyimide alignment layer/ITO slide.
Electrical characterization of organic light-emitting diodes using dipotassium phthalate as n-type dopant (2008)

An efficient n-doped electron transport layer composed of 4,7-diphenyl-1,10-phenanthroline (BPhen) and dipotassium phthalate (PAK2) has been developed. By temperature-dependent admittance spectroscopy, the incorporation of PAK2 into BPhen is found to raise the Fermi level from 1.7eV to only around 0.5eV below BPhen’s lowest unoccupied molecular orbital, which further enhances the efficiency of electron injection from an Al cathode. When this n-doped layer is adopted in an organic light-emitting diode device, the green fluorescent 10-(2-benzothiazolyl)-1,1,7,7-tetramethyl-2,3,6,7-tetrahydro-1H,5H,11H-benzo[l]-pyrano[6,7,8-ij]quinolizin-11-one do-ped device can achieve a current efficiency of 16cd∕A and a power efficiency of 10.9lm∕W at 1000cd∕m2.
Dopamine Restores Lung Ability to Clear Edema in Rats Exposed to Hyperoxia (1999)

Exposure to hyperoxia causes lung injury, decreases active sodium transport and lung edema clearance in rats. Dopamine (DA) increases lung edema clearance by stimulating vectorial Na+ flux and Na, K-ATPase function in rat alveolar epithelium. This study was designed to test whether DA (10(-)5 M) would increase lung edema clearance in rats exposed to 100% O2 for 64 h. Active Na+ transport and lung edema clearance decreased by approximately 44% in rats exposed to acute hyperoxia (p < 0.001). DA increased lung edema clearance in room air breathing rats (from 0.50 +/- 0.02 to 0.75 +/- 0.06 ml/h) and in rats exposed to 100% O2 (from 0.28 +/- 0.03 to 0. 67 +/- 0.03 ml/h). Disruption of cell microtubular transport system by colchicine blocked the stimulatory effect of DA on active Na+ transport in control and hyperoxic rats, whereas the isomer beta-lumicolchicine, which does not affect cell microtubular transport, did not inhibit the stimulatory effects of dopamine. The Na,K-ATPase alpha1-subunit protein abundance increased in the basolateral membranes of alveolar type II (ATII) cells incubated with 10(-)5 M DA for 15 min, probably by recruiting Na+ pumps from intracellular pools. Colchicine, but not beta-lumicolchicine, prevented the recruitment of alpha1 subunits to the plasma membrane by DA. Accordingly, DA restored lung ability to clear edema in hyperoxic-injured rat lungs. Conceivably, dopamine induces recruitment of Na+ pumps from intracellular pools to the plasma membrane of alveolar epithelial cells and thus increases lung edema clearance.
Advance Power Technology Experiment for the Starshine 3 Satellite (2001)

The Starshine 3 satellite will carry several power technology demonstrations. Since Starshine 3 is primarily a passive experiment and does not need electrical power to successfully complete its mission, the requirement for a highly reliable power system is greatly reduced. This creates an excellent opportunity to test new power technologies. Several government and commercial interests have teamed up to provide Starshine 3 with a small power system using state-of-the-art components. Starshine 3 will also fly novel integrated microelectronic power supplies (IMPS) for evaluation.
A method for determining the appropriate frequency for testing asphalt mixtures in the laboratory (2019)

Determination of the properties of viscoelastic materials like asphalt mixtures in laboratory requires applying loads that are representative of real loading. Traffic loads in the laboratory are simulated using different waveforms, through combinations of amplitude and frequency. This study proposes a simple and practical approach for determining the loading frequency for laboratory applications, based on linear elastic computer simulations of different pavement structures under various loading configurations. Two methods were investigated to find the influence zone of the load in the pavement and the frequency of the load based on the assumed load velocities. These two approaches resulted in different frequencies. As simulation of the waveform using the first method (using a predetermined drop in normalized horizontal stress) is not practical for simulation of waveforms. Use of the second method,developed based on analysis of shape of stress distribution is recommended as the reasonable and feasible approach.
Uncovering the Genetic Landscape for Multiple Sleep-Wake Traits (2009)

Despite decades of research in defining sleep-wake properties in mammals, little is known about the nature or identity of genes that regulate sleep, a fundamental behaviour that in humans occupies about one-third of the entire lifespan. While genome-wide association studies in humans and quantitative trait loci (QTL) analyses in mice have identified candidate genes for an increasing number of complex traits and genetic diseases, the resources and time-consuming process necessary for obtaining detailed quantitative data have made sleep seemingly intractable to similar large-scale genomic approaches. Here we describe analysis of 20 sleep-wake traits from 269 mice from a genetically segregating population that reveals 52 significant QTL representing a minimum of 20 genomic loci. While many (28) QTL affected a particular sleep-wake trait (e.g., amount of wake) across the full 24-hr day, other loci only affected a trait in the light or dark period while some loci had opposite effects on the trait during the light vs. dark. Analysis of a dataset for multiple sleep-wake traits led to previously undetected interactions (including the differential genetic control of number and duration of REM bouts), as well as possible shared genetic regulatory mechanisms for seemingly different unrelated sleep-wake traits (e.g., number of arousals and REM latency). Construction of a Bayesian network for sleep-wake traits and loci led to the identification of sub-networks of linkage not detectable in smaller data sets or limited single-trait analyses. For example, the network analyses revealed a novel chain of causal relationships between the chromosome 17@29cM QTL, total amount of wake, and duration of wake bouts in both light and dark periods that implies a mechanism whereby overall sleep need, mediated by this locus, in turn determines the length of each wake bout. Taken together, the present results reveal a complex genetic landscape underlying multiple sleep-wake traits and emphasize the need for a systems biology approach for elucidating the full extent of the genetic regulatory mechanisms of this complex and universal behavior.
Some aspects of modified factorial series distributions (2000)

Abstract This paper reviews the main results obtained so far in the field of discrete distributions involving factorial series distributions, Stirling numbers of first kind and second kind, Markov-Polya survival model, associated Lah numbers and C-numbers etc. The combinatorial proof of the modified factorial series expansion and the modified multivariate factorial series expansion are applied respectively while studying modified factorial series distributions (MFSDs) and modified multivariate factorial series distributions (MMFSDs). A few well known univariate as well as multivariate distributions are derived by the use of the MFSDs and MMFSDs. Some univariate distributions involving Stirling numbers of first kind and second kind under different sampling schemes are mostly studied via urn models.
Identification autodidacte au second ordre d'un système multi-entrées / multi-sorties bruité : Le cas d'un bruit temporellement blanc et spatialement coloré (1997)

Dans cet article, nous considerons l'identification autodidacte d'un systeme p entrees / q sorties (avec p < q) de reponse impulsionnelle infinie H(z), excite par un bruit blanc, et perturbe par un bruit additif temporellement blanc mais de matrice de covariance inconnue. Nous montrons que sous certaines conditions H(z) est identifiable a partir de la fonction d'autocovariance de l'observation. Nous proposons egalement des procedures simples d'identification.
Self-propelling rotator driven by soluto-capillary marangoni flows (2017)

The self-propelled, longstanding rotation of the polymer tubing containing camphor continuing for dozens of hours is reported. The rotator is driven by the solutocapillary Marangoni flows owing to the dissolution of camphor. The phenomenological model of self-propulsion is suggested and verified. Scaling laws describing the quasi-stationary self-propulsion are proposed and tested experimentally. The change in the surface tension, arising from the dissolution of camphor and driving the rotator, is estimated as 0.3 mN/m.