gebhart/patrepeval huggingface dataset:
Damage Tolerance Based Life Prediction in Gas Turbine Engine Blades Under Vibratory High Cycle Fatigue (1997)

A novel fracture mechanics approach has been used to predict crack propagation lives in gas turbine engine blades subjected to vibratory high cycle fatigue (HCF). The vibratory loading included both a resonant mode and a nonresonant mode, with one blade subjected to only the nonresonant mode and another blade to both modes. A life prediction algorithm was utilized to predict HCF propagation lives for each case. The life prediction system incorporates a boundary integral element (BIE) derived hybrid stress intensity solution, which accounts for the transition from a surface crack to corner crack to edge crack. It also includes a derivation of threshold crack length from threshold stress intensity factors to give crack size limits for no propagation. The stress intensity solution was calibrated for crack aspect ratios measured directly from the fracture surfaces. The model demonstrates the ability to correlate predicted missions to failure with values deduced from fractographic analysis. This analysis helps to validate the use of fracture mechanics approaches for assessing damage tolerance in gas turbine engine components subjected to combined steady and vibratory stresses.
Development of Mixed Th1/Th2 Type Immune Response and Protection Against Mycobacterium tuberculosis After Rectal or Subcutaneous Immunization of Newborn and Adult Mice with Mycobacterium bovis BCG (2002)

Cell-mediated immunity plays a key role in containing the growth of Mycobacterium tuberculosis in the host. The induction of an antibody response or a mixed cell-mediated and humoral response is frequently associated with tuberculosis disease or a decrease in the ability to control M. tuberculosis load. We recently reported the induction of similar immune responses and protection by rectal, subcutaneous (SC) or intradermal administration of Mycobacterium bovis BCG in adult mice, guinea pigs and macaques. The rectal immunization, which did not induce the side-effects associated with parenteral routes (axillary adenitis) and which could be used to reduce the risks of viral transmission associated with unsafe injections in the developing world, was analysed and compared in newborn and adult BALB/c mice. The rectal and SC immunization induced, in mice immunized as newborns or as adults, a mixed T helper 1/T helper 2 (Th1/Th2) immune response; however, particularly in adult mice, after SC administration of BCG, the level of Th2 immune response is significantly higher than it is by the rectal route. Six months after immunization with BCG, rectal and SC delivery induced similar levels of protective immunity against a virulent challenge with M. tuberculosis strain (H37Rv) in mice immunized as adults, but the rectal BCG delivery triggered stronger protection than the SC delivery if mice were immunized as newborns.
Enhanced Gas Detection by Altering Gate Voltage Polarity of Polypyrrole/Graphene Field-Effect Transistor Sensor (2022)

This work introduces a new measurement methodology for enhancing gas detection by tuning the magnitude and polarity of back-gate voltage of a field-effect transistor (FET)-based sensor. The aim is to simultaneously strengthen the sensor response and accelerate the sensor recovery. In addition, this methodology can consume less energy compared with conventional measurements by direct current bias. To illustrate the benefits of the proposed methodology, we fabricated and characterized a polypyrrole/graphene (PPy/G) FET sensor for ammonia (NH3) detection. Our experiment, simulation and calculation results demonstrated that the redox reaction between the NH3 molecules and the PPy/G sensitive layer could be controlled by altering the polarity and the magnitude of the back-gate voltage. This proof-of-principle measurement methodology, which solves the inherent contradiction between high response and slow recovery of the chemiresistive sensor, could be extended to detect other gases, so as to improve global gas measurement systems. It opens up a new route for FET-based gas sensors in practical applications.
Aminomalonic acid. Spontaneous decarboxylation and reaction with 5-deoxypyridoxal (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAminomalonic acid. Spontaneous decarboxylation and reaction with 5-deoxypyridoxalJohn W. ThanassiCite this: Biochemistry 1970, 9, 3, 525–532Publication Date (Print):February 3, 1970Publication History Published online1 May 2002Published inissue 3 February 1970https://pubs.acs.org/doi/10.1021/bi00805a011https://doi.org/10.1021/bi00805a011research-articleACS PublicationsRequest reuse permissionsArticle Views335Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
afsS is a target of AfsR, a transcriptional factor with ATPase activity that globally controls secondary metabolism in Streptomyces coelicolor A3(2) (2002)

AfsR is a pleiotropic, global regulator that controls the production of actinorhodin, undecylprodigiosin and calcium-dependent antibiotic in Streptomyces coelicolor A3(2). AfsR, with 993 amino acids, is phosphorylated on serine and threonine residues by a protein serine/threonine kinase AfsK and contains an OmpR-like DNA-binding fold at its N-terminal portion and A- and B-type nucleotide-binding motifs in the middle of the protein. The DNA-binding domain, in-dependently of the nucleotide-binding domain, contributed the binding of AfsR to the upstream region of afsS that locates immediately 3' to afsR and encodes a 63-amino-acid protein. No transcription of afsS in the DeltaafsR background and restoration of afsS transcription by afsR on a plasmid in the same genetic background indicated that afsR served as a transcriptional activator for afsS. Interestingly, the AfsR binding site overlapped the promoter of afsS, as determined by DNase I protection assay and high-resolution S1 nuclease mapping. The nucleotide-binding domain contributed distinct ATPase and GTPase activity. The phosphorylation of AfsR by AfsK greatly enhanced the DNA-binding activity and modulated the ATPase activity. The DNA-binding ability of AfsR was independent of the ATPase activity. However, the ATPase activity was essential for transcriptional activation of afsS, probably because the energy available from ATP hydrolysis is required for the isomerization of the closed complex between AfsR and RNA polymerase to a transcriptionally competent open complex. Thus, AfsR turns out to be a unique transcriptional factor, in that it is modular, in which DNA-binding and ATPase activities are physically separable, and the two functions are modulated by phosphorylation on serine and threonine residues.
[Nb{B(η6‐C6H5)2(C6H5)2}(η2‐H3CC2CH3)]: the First Compound with Bent Tetraphenylborate as 12‐Electron Donor Ligand (1992)

The “counterion” BPh functions a sandwich ligand in the niobium(I) complex 1. This is confirmed by the X-ray structure analysis of 1a. The BPh complexes 1 are the first in which two of the four phenyl rings of the tetraphenylborate bind to one metal center. Such complexes could be important as model compounds for catalytic processes.
AlOx Coating of Ultrastable Zeolite Y:  A Possible Method for Vanadium Passivation of FCC Catalysts (2000)

AlOx coating is proposed as a possible method for vanadium passivation of the ultrastable zeolite Y (USY). Two coating methods are discussed: (i) the deposition of the [Al13O4(OH)24(H2O)12]7+ ([Al13]) complex from aqueous solutions and (ii) the anchoring of alumoxane by in situ triisobutylaluminum hydrolysis followed by calcination. The properties and the efficiency in vanadium passivation of the coated materials have been investigated with DRS, ESR, XPS, FTIR, and sorption measurements. XPS revealed for all the coated samples an enrichment in the Al content in the near-surface region and differences in Al coordination geometry. Vanadyl(IV) etioporphyrin, the major contaminant in crude oil, was used to probe the trapping efficiency of the external AlOx layer. The [Al13]-derived layer is homogeneously distributed and covers the external surface of the USY zeolite, following its topology, but without blocking its pores. About 80% of the offered vanadyl species have been preferentially trapped in this layer. The alumoxane-based method is less efficient in vanadium passivation, most probably because after calcination the aluminum species are heterogeneously distributed, both on the external surface and in the channels of USY zeolite.
17O NMR studies on ?-diamides (1998)

17O NMR spectra of several α-diamides were obtained at natural isotopic abundance in acetonitrile solution in order to study the conformations of these compounds in solution. The 17O NMR shifts vary with the intercarbonyl dihedral angle α in a sense opposite to that observed for α-diketones. © 1998 John Wiley & Sons, Ltd.
Context-Aware Anomaly Detection for Electronic Medical Record Systems. (2011)

The electronic medical record (EMR) system is a critical component of a modern health information architecture. EMRs are increasingly connected to a diverse array of systems that support healthcare business operations, such as clinical documentation, laboratory reporting, radiology services, pharmaceutical dispensing, and billing. The complexity of this domain creates challenges for ensuring patient data security and compliance with regulations (e.g., HIPPA). Certain challenges are common across domains and have thus been addressed through traditional solutions. For instance, exploits against the external perimeter of EMR systems are mitigated by network-based intrusion detection systems (IDS), hardening operating systems, and updating security patches. Additionally, access control mechanisms have been adopted by EMRs to enforce users' privileges with respect to patient records. Beyond access control, the notion of experience based access management (EBAM) has been proposed to refine access control assignments via documented user behavior [4].

Other challenges are unique to the clinical domain. First, EMR systems are connected to web portals and exposed to the Internet for a wide range of users; e.g., patients, providers. The vulnerabilities within web-based systems attract various attacks, which are difficult to detect because they exploit the semantics of clinical operations. Second, healthcare organizations use a coarsegrained implementation of access control. This is because access control mechanisms do not scale to manage the large number of clinical functions that can be invoked (e.g., medication ordering, laboratory report editing, consult requests). Third, clinical treatment guidelines are usually too complex to be modeled and explicitly enforced, which may lead to guideline violation by insiders.

Our objective is to build a context-aware anomaly detection system that is customized to the needs of the clinical domain and EMR systems. Our detection system will model the characteristics of EMR systems, monitor the system usage, and detect anomalous user behaviors. This system can help realize the user behavior monitoring component of an EBAM framework.
Glioma Cells Display Complex Cell Surface Topographies That Resist the Actions of Cytolytic Effector Lymphocytes (2010)

Gliomas are invasive cancers that resist all forms of attempted therapy. Immunotherapy using Ag-pulsed dendritic cells has improved survival in some patients. We present evidence that another level of complexity may also contribute to lack of responses by the lymphocytes toward gliomas. Atomic force microscopy of four different glioma types-human U251 and rat T9 and F98 glioma cells, including freshly isolated human glioblastoma multiforme neurosphere cultures (containing "stem cell-like cells")-revealed a complex surface topography with numerous microvilli and filopodia. These structures were not found on other cell types. Electron microscopy and immunofluorescence microscopy of glioma cells confirmed that microvilli are present. U251 cells with microvilli resisted the cytolytic actions of different human effector cells, (lymphokine-activated killer cells, γδ T cells, conventional CTLs, and chimeric Ag-receptor-redirected T cells) better than their nonmicrovilli-expressing counterparts. Killer lymphocytes released perforin, which was detected within the glioma's microvilli/filopodia, indicating these structures can receive the cytolytic effector molecules, but cytotoxicity is suboptimal. Air-dried gliomas revealed nodes within the microvilli/filopodia. The microvilli that penetrated 0.4-μm transwell chamber's pores resisted the actions of CTLs and physical damage. Those nodelike structures may represent a compartmentalization that resists physical damage. These microvilli may play multiple roles in glioma biology, such as invasion and resistance to lymphocyte-mediated killing.
Myocardial ischemia and reperfusion injury is dependent on both IgM and mannose-binding lectin (2009)

Complement activation has been shown to play an important role in the inflammation and tissue injury following myocardial ischemia and reperfusion (MI/R). Several recent studies from our laboratory demonstrated the importance of mannose-binding lectin (MBL) as the initiation pathway for complement activation and the resulting pathological effects following MI/R. However, other studies from the past suggest an important role of the classical pathway and perhaps natural antibodies. In the present study, we used newly generated genetically modified mice that lack secreted IgM (sIgM), MBL-A, and MBL-C (sIgM/MBL null) in a plasma reconstitution mouse model of MI/R. Following 30 min of ischemia and 4 h of reperfusion, left ventricular ejection fractions were significantly higher in sIgM/MBL null mice reconstituted with MBL null or sIgM/MBL null plasma compared with reconstitution with wild-type (WT) plasma or WT mice reconstituted with WT plasma following MI/R. Serum troponin I concentration, myocardial polymorphonuclear leukocyte infiltration, and C3 deposition were dependent on the combined presence of sIgM and MBL. These results demonstrate that MI/R-induced complement activation, inflammation, and subsequent tissue injury require both IgM and MBL. Thus MBL-dependent activation of the lectin pathway may not be completely antibody independent in I/R models.
Recent Technologies in Japan on Array Antennas for Wireless Systems (2017)

Array antenna technology for wireless systems is highly integrated for demands such as multi-functionality and high-performance. This paper details recent technologies in Japan in design techniques based on computational electromagnetics, antenna hardware techniques in the millimeter-wave band, array signal processing to add adaptive functions, and measurement methods to support design techniques, for array antennas for future wireless systems. Prospects of these four technologies are also described.
Apraxia of Eyelid Opening Improved by Pallidal Stimulation in Progressive Supranuclear Palsy (2020)

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Patellofemoral arthroplasty: expert opinion (2022)

Isolated patellofemoral osteoarthritis (PFOA) is a common cause of anterior knee pain in patients over the age of 40 years. Patellofemoral arthroplasty (PFA) is an option to address PFAO when the non-operative or joint preserving management has failed.The goals of PFA are to reduce pain and increase function of the knee in a bone and ligament preserving fashion while maintaining or optimizing its kinematics. Over the last decades advances have been made in optimizing implants designs, addressing complications and improving functional and patient reported outcomes. Appropriate patient selection has proven to be imperative. Proper surgical technique and knowledge of pearls and pitfalls is essential.The indications and surgical technique for patellofemoral arthroplasty will be reviewed here.Level of evidence: Therapeutic Level V.
A Self-Aware Architecture for PVT Compensation and Power Nap in Near Threshold Processors (2017)

As technology edges closer to fundamental limits, variations of process parameters, operational voltage, and temperature (PVT variations) have to be accounted for. This paper proposes to make higher levels aware of these variations and bring them under system control by using software controlled body biasing. PVT variations can thus be exploited to reduce power and energy consumption.— <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Axel Jantsch, TU Wien</i>
Behavioral, cognitive, and adaptive development in infants with autism spectrum disorder in the first 2 years of life (2015)

These findings reveal atypical sensorimotor development at 6 months of age which is associated with ASD at 24 months in the most severely affected group of infants. Sensorimotor differences precede the unfolding of cognitive and adaptive deficits and behavioral features of autism across the 6- to 24-month interval. The less severely affected group demonstrates later symptom onset, in the second year of life, with initial differences in the social-communication domain.
A Comparison of T4:T8 Lymphocyte Ratio in the Periodontal Lesion of Healthy and HIV‐Positive Patients (1992)

Previous reports describe a characteristic, rapidly progressive, periodontitis that is unique to patients who are seropositive for HIV antibody (Western blot +). The purpose of this study was to compare the T4 and T8 lymphocyte subpopulations in the peripheral blood and periodontal lesions of these HIV patients with those of healthy controls. T-cell subsets in peripheral blood were quantified by flow cytometry. The values from this analysis were used to calculate the peripheral T4:T8 lymphocyte ratio for each patient. Gingival tissue (papilla) was obtained from 8 HIV+ patients and from 6 healthy HIV- control patients during routine gingival surgery. The T-cell subpopulations in the gingival tissue were determined using serial cryostat sections that were labeled with monoclonal antibodies for T4 and T8 cells and developed using an avidin-biotin-peroxidase system. Six sections were taken from each of the 14 tissue specimens (one per patient). The sections were examined at 450 x and the mean number of T4 and T8 cells calculated for each section. These mean values were then used to determine the T4:T8 lymphocyte ratio for each tissue specimen. The peripheral blood analysis revealed a mean serum T4:T8 ratio of (2.07 +/- 0.455) for the controls and (0.58 +/- 0.26) for the HIV patients. The significantly lower T4:T8 ratio in HIV patients is consistent with their diagnosis. Although the results indicated that the mean T4:T8 lymphocyte ratio in the gingiva of controls was highly variable (2.70 +/- 1.344), the gingiva of HIV patients consistently exhibited a complete absence of T-cells.(ABSTRACT TRUNCATED AT 250 WORDS)
Can a few good cells now mend a broken heart? (1993)

Can a Few Good Cells Now Mend a Broken Heart? Editorial "Only love can mend a broken heart." -Dionne Warwick Burt
Heparan Sulfate and Fibronectin Improve the Capacity of Collagen Barriers to Prevent Apical Migration of the Junctional Epithelium (1991)

The objective of the present study was to assess the effect of bilayered/collagen barriers enriched with fibronectin and heparan sulfate on the prevention of apical migration of the epithelium during the initial stage of periodontal wound healing. Experimental osseous defects were produced on the labial aspect of maxillary canines in dogs. Experimental sites were treated with either bilayered enriched collagen barriers or with non-enriched bilayered collagen barriers, using the guided tissue regeneration technique. Control sites were treated with monolayered collagen barriers that were not enriched with fibronectin and heparan sulfate. Histologic and histomorphometric examinations performed on specimens obtained 20 days post-operative indicate the formation of a short junctional epithelium in the experimental sites treated with enriched collagen barriers. In this group, 95% of the occlusal-apical length of the defects was repopulated by connective tissue cells. In the other 2 groups, a long junctional epithelium developed with only 65% of the occlusal-apical length of the defects being repopulated by connective tissue cells. These findings suggest that the enrichment of collagen barriers with fibronectin and heparan sulfate may be important to enhance the repopulation of exposed root surfaces by connective tissue cells and prevent the apical migration of the epithelium during the initial stages of periodontal wound healing.
[A set of indicators to monitor the adherence to the guidelines for the diagnosis and treatment of breast cancer]. (2015)

the study presents data derived from a large cohort of population cases; the set of indicators was validated by a board of oncologists. The use of indicators calculated by linking the cancer registries (that provide staging) and administrative databases allows the assessment of compliance to the guidelines for diagnosis and treatment of tumours. This experience shows that it is possible to develop a methodology, shared with clinicians, to define indicators that measure the distance between guidelines and current clinical practice in order to decrease variability, to limit inappropriateness, and to reduce unnecessary diagnostic tests for patients (and, consequently, hospitals organizational overload). In order to be sustainable and equitable, a health care system must be able to ensure implementation of protocols/procedures based exclusively on the best available scientific evidences.
Determination of aluminum soaps in pitch deposits by gas chromatography (2010)

Aluminum soaps can be determined by formation of aluminum-acetylacetonate chelates that are volatile enough to be analyzed by gas chromatography. Application of the technique to pitch deposits containing aluminum soaps entails acid hydrolysis to break down the aluminum soaps, chelation of the aluminum with acetylacetonate at pH &gt;6, and analysis of the aluminum chelates by gas chromatography. The technique offers results that are comparable to those obtained by a traditional, much longer method that requires acid digestion of aluminum soaps and analysis of aluminum content by inductively coupled plasma spectroscopy.
Electronic Decay Length in a Protein Molecule (2019)

Antibodies have two identical binding domains and can therefore form a well-defined conducting bridge by binding a pair of electrodes functionalized with an epitope. The conductance measured between these two fixed points on the antibody does not change with the size of the electrode gap. A second conduction path is via one specific attachment to an epitope and a second nonspecific attachment to the surface of the antibody. In this case, the conductance does change with gap size, yielding an estimated electronic decay length >6 nm, long enough that it is not possible to distinguish between an exponential or a hyperbolic distance dependence. This decay length is substantially greater than that measured for hopping transport in an organic molecular wire.