gebhart/patrepeval huggingface dataset:
Across-frequency interference effects in fundamental frequency discrimination: Questioning evidence for two pitch mechanisms (2004)

Carlyon and Shackleton [J. Acoust. Soc. Am. 95, 3541-3554 (1994)] presented an influential study supporting the existence of two pitch mechanisms, one for complex tones containing resolved and one for complex tones containing only unresolved components. The current experiments provide an alternative explanation for their finding, namely the existence of across-frequency interference in fundamental frequency (F0) discrimination. Sensitivity (d') was measured for F0 discrimination between two sequentially presented 400 ms complex (target) tones containing only unresolved components. In experiment 1, the target was filtered between 1375 and 15,000 Hz, had a nominal F0 of 88 Hz, and was presented either alone or with an additional complex tone ("interferer"). The interferer was filtered between 125-625 Hz, and its F0 varied between 88 and 114.4 Hz across blocks. Sensitivity was significantly reduced in the presence of the interferer, and this effect decreased as its F0 was moved progressively further from that of the target. Experiment 2 showed that increasing the level of a synchronously gated lowpass noise that spectrally overlapped with the interferer reduced this "pitch discrimination interference (PDI)". In experiment 3A, the target was filtered between 3900 and 5400 Hz and had an F0 of either 88 or 250 Hz. It was presented either alone or with an interferer, filtered between 1375 and 1875 Hz with an F0 corresponding to the nominal target F0. PDI was larger in the presence of the resolved (250 Hz F0) than in the presence of the unresolved (88 Hz F0) interferer, presumably because the pitch of the former was more salient than that of the latter. Experiments 4A and 4B showed that PDI was reduced but not eliminated when the interferer was gated on 200 ms before and off 200 ms after the target, and that some PDI was observed with a continuous interferer. The current findings provide an alternative interpretation of a study supposedly providing strong evidence for the existence of two pitch mechanisms.
Myc represses the p21 (WAF1/CIP1) promoter and interacts with Sp1/Sp3 (2001)

The cyclin-dependent kinase inhibitor p21((WAF1/CIP1)) inhibits proliferation both in vitro and in vivo, and overexpression of p21 in normal and tumor cell lines results in cell cycle arrest. In contrast, ectopic expression of Myc alleviates G(1) cell cycle arrest. Recent studies showed that Myc can repress p21 transcription, thereby overriding a p21-mediated cell cycle checkpoint. We found that activation of a Myc-estrogen receptor fusion protein by 4-hydroxytamoxifen in mouse cells resulted in suppression of endogenous p21 transcription. This effect was observed in the absence of de novo protein synthesis and was independent of histone deacetylase activity. In transient transfection studies, Myc effectively repressed p21 promoter constructs containing only 119 bp of sequence upstream of the transcription start site. This region contains multiple Sp1-binding sites and a potential initiator element, but no canonical Myc DNA-binding sites. Deletion of the potential initiator element does not affect repression of the p21 promoter by c-Myc. Coimmunoprecipitation and glutathione S-transferase pull-down experiments demonstrate that c-Myc may form complexes with Sp1/Sp3. We found that the central region of c-Myc interacts with the zinc finger domain of Sp1. Because Sp1 is required for p21 transcription, it is possible that Myc may down-regulate p21 transcription, at least in part, by sequestering Sp1. Repression of the p21 promoter may contribute to the ability of c-Myc to promote cell proliferation.
VLSI-enabled DNA sequencing arrays (2011)

Massively-parallel, integrated, sensitive and low-cost bio-molecular detectors are an essential part of “next generation” DNA sequencing systems. This paper discusses various design methodologies that leverage the versatility of VLSI technologies, specifically CMOS fabrication processes, to build highly integrated sequencing arrays while addressing the stringent detection and integration requirements. The goal of this paper is to discuss both the advantages and the limitations of next generation VLSI-enabled DNA sequencers.
Central Venous Pressure at Emergency Room Presentation Predicts Cardiac Rehospitalization in Patients with Decompensated Heart Failure (2010)

Central venous pressure at ER presentation in patients with DHF is an independent predictor of cardiac rehospitalization but not of cardiac and all-cause mortality.
A Case of Neurofibromatosis Type 1 Whose Life Was Saved after Rapid Cervical Swelling and Airway Stenosis Caused by Multiple Arterial Ruptures (2022)

神経線維腫症1型（neurofibromatosis; NF-1）はまれに動脈狭窄・動脈瘤・動静脈瘻・動静脈奇形などの血管病変を合併すると言われている。血管脆弱性に起因すると思われるこうした血管病変は，発生箇所や条件によっては致命的な合併症を引き起こす。今回，NF-1に合併した胸肩峰動脈および上行咽頭動脈破裂に対して，緊急気管切開・血管内治療で救命しえた症例を経験した。同時に2カ所からの動脈性出血を起こし救命しえた例はまれであり，文献的考察を加えて報告する。症例はNF-1の61歳の女性，軽度の頸部への刺激後より急激な腫脹が出現したため受診した。気道狭窄に対して緊急気管切開を行い，創部からの著しい出血を認めたため出血源検索で施行した造影CTで右頸部に巨大血腫および造影剤の漏出を認めた。動脈破裂による急激な頸部腫脹を疑い，血管造影を施行し出血源に対してtranscatheter arterial embolization（TAE）を行い，止血を得られ救命することができた。NF-1症例で，頸部からの出血をきたした場合には緊急での気道確保が必要となると考えられ，われわれ耳鼻咽喉科・頭頸部外科医もこうした合併症について熟知しておく必要があると考えられる。
Treatments for chronic fatigue syndrome (2005)

By applying the models of fatigue that form the bases for cognitive behaviour therapy and graded exercise therapy, occupational health physicians may play an important role in helping the patients with chronic fatigue syndrome to reduce their symptoms, improve their functioning and return to work.
Simultaneous measurement of temperature and strain distribution using Brillouin scattering in dispersion-shifted fibers (2011)

We studied Brillouin gain spectrum characteristics in dispersion-shifted fibers having compound GeO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> -doping compositions in the fiber core to realize simultaneous measurement of distributed strain and temperature. Due to various dopant concentration alongside the radius of tested nonzero dispersion-shifted fibers several multiple Brillouin scattering resonances were observed in the stimulated Brillouin spectra arose through backscattering on higher acoustic modes which propagated along the fiber axis. As a result of the varying acoustic velocities, the Brillouin resonance peaks featured different temperature coefficients which can be used to accomplish the simultaneous measurement of fiber strain and temperature. We presented our first measurement results for NZDS Fujikura and LEAF Corning fiber and discussed the superior sensory suitability of the former fiber types.
Online learning with adversarial delays (2015)

We study the performance of standard online learning algorithms when the feed-back is delayed by an adversary. We show that online-gradient-descent [1] and follow-the-perturbed-leader [2] achieve regret O( D) in the delayed setting, where D is the sum of delays of each round’s feedback. This bound collapses to an optimal O( T) bound in the usual setting of no delays (where D = T). Our main contribution is to show that standard algorithms for online learning already have simple regret bounds in the most general setting of delayed feedback, making adjustments to the analysis and not to the algorithms themselves. Our results help affirm and clarify the success of recent algorithms in optimization and machine learning that operate in a delayed feedback model. 1
Variable inductor modeling revisited: The analytical approach (2017)

This paper presents the modeling of variable inductors (VI) following an analytical procedure. Usually, in a VI a dc magnetic flux is injected into the structure in order to provide a bias level that allows for magnetic permeability modulation. The ac magnetic flux is superposed to this dc level, thus making it possible that a variable inductance can be seen from the ac windings. Under the assumption that the ac magnetic flux amplitude is much smaller than the bias level, it is possible to analyze the VI by applying the superposition principle to the equivalent reluctance circuit of the structure. This procedure is illustrated in this paper for a double-E based VI. The proposed methodology is supported by both simulation and experimental results for a particular VI.
Thromboelastometry demonstrates endogenous coagulation activation in nonsevere and severe COVID-19 patients and has applicability as a decision algorithm for intervention (2022)

In patients with severe forms of COVID-19, thromboelastometry has been reported to display a hypercoagulant pattern. However, an algorithm to differentiate severe COVID-19 patients from nonsevere patients and healthy controls based on thromboelastometry parameters has not been developed. Forty-one patients over 18 years of age with positive qRT-PCR for SARS-CoV-2 were classified according to the severity of the disease: nonsevere (NS, n = 20) or severe (S, n = 21). A healthy control (HC, n = 9) group was also examined. Blood samples from all participants were tested by extrinsic (EXTEM), intrinsic (INTEM), non-activated (NATEM) and functional assessment of fibrinogen (FIBTEM) assays of thromboelastometry. The thrombodynamic potential index (TPI) was also calculated. Severe COVID-19 patients exhibited a thromboelastometry profile with clear hypercoagulability, which was significantly different from the NS and HC groups. Nonsevere COVID-19 cases showed a trend to thrombotic pole. The NATEM test suggested that nonsevere and severe COVID-19 patients presented endogenous coagulation activation (reduced clotting time and clot formation time). TPI data were significantly different between the NS and S groups. The maximum clot firmness profile obtained by FIBTEM showed moderate/elevated accuracy to differentiate severe patients from NS and HC. A decision tree algorithm based on the FIBTEM-MCF profile was proposed to differentiate S from HC and NS. Thromboelastometric parameters are a useful tool to differentiate the coagulation profile of nonsevere and severe COVID-19 patients for therapeutic intervention purposes.
Photografting as a simple and versatile functionalization route of silica-based monoliths (2013)

communication par affiche
The authors reply (2021)

1 Department of Emergency and Disaster Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan 2 Department of Anesthesiology, Critical Care, and Surgery, Duke University School of Medicine, Durham, NC 3 Department of Pathology and Molecular Medicine and Department of Medicine, McMaster University, Hamilton, ON, Canada Dr. Levy disclosed that he serves on the steering committees for Instrumentation Laboratory, Octapharma, and Merck. Dr. Warkentin received funding from Aspen Global, Bayer, CSL, Behring, Ergomed, Instrumentation Laboratory, Octapharma, and Informa (Taylor & Francis); he received support for article research from Instrumentation Laboratory and consulting fees related to medical-legal consulting and testimony. Dr. Iba has received a research grant from Japan Blood Products Organization and JIMRO.
Resonant four-photon scattering of collinear laser pulses in plasma (2020)

Exact four-photon resonance of collinear planar laser pulses is known to be prohibited by the classical dispersion law of electromagnetic waves in plasma. We show here that the renormalization produced by an arbitrarily small relativistic electron nonlinearity removes this prohibition. The laser frequency shifts in collinear resonant four-photon scattering increase with laser intensities. For laser pulses of frequencies much greater than the electron plasma frequency, the shifts can also be much greater than the plasma frequency and even nearly double the input laser frequency at still small relativistic electron nonlinearities. This may enable broad range tunable lasers of very high frequencies and powers. Since the four-photon scattering does not rely on the Langmuir wave, which is very sensitive to plasma homogeneity, such lasers would also be able to operate at much larger plasma inhomogeneities than lasers based on stimulated Raman scattering in plasma.
H∞ bumpless transfer for switched LPV systems and its application (2017)

In this paper, the approach of the control bumps limitation is generalised and applied to the problem of H ∞ bumpless transfer for a class of switched linear parameter-varying (LPV) systems. The H ∞ bumpless transfer problem is to design a controller with the amplitude limitation and a parameter and modes-dependent switching law to reduce control bumps of the switched LPV systems and satisfy an H ∞ performance index. The key point is to guarantee the bumps limitation constraint of the switched LPV systems by dual design of controllers and a switching law, even though the constraint for each subsystem is unsatisfied. First, a set of switching signals depending on parameters and modes are designed, and a family of switched LPV controllers with the bumps limitation objective are developed via multiple parameter-dependent Lyapunov functions. Then, a sufficient condition ensuring the H ∞ bumpless transfer performance for a switched LPV system is presented in the format of numerically tractable conditions. Finally, the effectiveness of the proposed control design scheme is illustrated by its application to the control design of an aero-engine.
THE TECHNIQUE OF LABELLED MITOSES: ANALYSIS BY AUTOMATIC CURVE‐FITTING (1971)

ABSTRACT An improved method is described for the analysis of data obtained by the technique of labelled mitoses. It is a development of the method described by Barrett (1966) in which theoretical curves are computed on the basis of a model which assumes that the phases G 1 , S and G 2 are described by independent log‐normal distributions; the analysis consists in finding a form of this model which gives a labelled mitoses curve which is the best fit to the available data. This fitting procedure has now been made automatic. No comprehensive indication of the goodness of fit can be given, although in the analysis of over fifty sets of data the method appears to have worked well. A supplementary computer program is described which, on the basis of three separate assumed modes of cell loss, calculates the form of the age distributions and theoretical continuous labelling curves. This allows growth fraction to be calculated in a way which takes account of the distribution of phase durations and the non‐rectangular age distributions of expanding cell populations. It also gives an opportunity to study the implications of continuous labelling data as regards the mode of cell loss. A comparison is made between the present method of labelled mitoses curve analysis and the empirical rules which have often been used.
Evaluation of Tebipenem Hydrolysis by β-Lactamases Prevalent in Complicated Urinary Tract Infections (2022)

Tebipenem pivoxil is the first orally available carbapenem antibiotic and has been approved in Japan for treating ear, nose, and throat and respiratory infections in pediatric patients. Its active moiety, tebipenem, has shown potent antimicrobial activity <i>in vitro</i> against clinical isolates of <i>Enterobacterales</i> species from patients with urinary tract infections (UTIs), including those producing extended-spectrum β-lactamases (ESBLs) and/or AmpC β-lactamase. In the present study, tebipenem was tested for stability to hydrolysis by a set of clinically relevant β-lactamases, including TEM-1, AmpC, CTX-M, OXA-48, KPC, and NDM-1 enzymes. In addition, hydrolysis rates of other carbapenems, including imipenem, meropenem, and ertapenem, were determined for comparison. It was found that, similar to other carbapenems, tebipenem was resistant to hydrolysis by TEM-1, CTX-M, and AmpC β-lactamases but was susceptible to hydrolysis by KPC, OXA-48, and NDM-1 enzymes with catalytic efficiency values (<i>k</i><sub>cat</sub>/<i>K<sub>m</sub></i>) ranging from 0.1 to 2 × 10<sup>6</sup> M<sup>-1</sup>s<sup>-1</sup>. This supports the reported results of antimicrobial activity of tebipenem against ESBL- and AmpC-producing but not carbapenemase-producing <i>Enterobacterales</i> isolates. Considering that CTX-M and AmpC β-lactamases represent the primary determinants of multidrug-resistant complicated UTIs (cUTIs), the stability of tebipenem to hydrolysis by these enzymes supports the utility of its prodrug tebipenem, tebipenem pivoxil hydrobromide (TBP-PI-HBr), as an oral therapy for adult cUTIs.
ChemInform Abstract: Synthetic Studies on Oligomycins. Synthesis of the Oligomycin B Polypropionate Portion (I). (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
MHC-Mismatched Islet Allografts Are Vulnerable to Autoimmune Recognition In Vivo (2005)

When transplanted into type 1a diabetic recipients, islet allografts are subject both to conventional allograft immunity and, presumably, to recurrent autoimmune (islet-specific) pathogenesis. Importantly, CD4 T cells play a central role both in islet allograft rejection and in autoimmune disease recurrence leading to the destruction of syngeneic islet transplants in diabetic NOD mice. However, it is unclear how NOD host MHC class II (I-A(g7))-restricted, autoreactive CD4 T cells may also contribute to the recognition of allogeneic islet grafts that express disparate MHC class II molecules. We hypothesized that islet-specific CD4 T cells can target MHC-mismatched islet allografts for destruction via the "indirect" (host APC-dependent) pathway of Ag recognition. To test this hypothesis, we determined whether NOD-derived, islet-specific CD4 T cells (BDC-2.5 TCR transgenic cells) could damage MHC-mismatched islets in vivo independent of conventional allograft immunity. Results demonstrate that BDC-2.5 CD4 T cells can vigorously destroy MHC class II-disparate islet allografts established in NOD.scid recipients. Tissue injury is tissue-specific in that BDC-2.5 T cells destroy donor-type islet, but not thyroid allografts established in the same NOD.scid recipient. Furthermore, BDC-2.5 CD4 T cells acutely destroy MHC class II-deficient islet allografts in vivo, indicating that autoimmune pathogenesis can be completely independent of donor MHC class II expression. Taken together, these findings indicate that MHC-mismatched islet allografts can be vulnerable to autoimmune pathogenesis triggered by autoreactive CD4 T cells, presumably through indirect autoantigen recognition in vivo.
Electron Vortex Beams in a Magnetic Field: A New Twist on Landau Levels and Aharonov-Bohm States (2012)

With their spiraling wavefronts, orbital angular momentum, and capability of interacting with applied magnetic fields, electron vortex beams make it possible to directly observe fundamental properties of quantum states of electrons in fields under an electron microscope.
Phase triangulation method for measuring 3D geometry of complex profile objects under dynamic noise (2020)

Abstract The paper proposes a method of phase triangulation for measuring the three-dimensional geometry of complex objects under conditions of dynamic noise. The method is based on statistical analysis of experimental data, adaptive filtering and use of a controlled source of structured exposure. Theoretical and experimental estimates of the error by the proposed method are presented in the paper. The method allows a reduction in the measurement error of the three-dimensional surface geometry of complex objects using phase triangulation methods.
DEMONSTRATION OF BLOCKING IMMUNOGLOBULINS G, HAVING A HETEROGENEOUS BEHAVIOUR, IN SERA OF PATIENTS WITH GRAVES' DISEASE: POSSIBLE COEXISTENCE OF DIFFERENT AUTOANTIBODIES DIRECTED TO THE TSH RECEPTOR (1988)

Previous studies by us and others have shown that Graves' immunoglobulins G (IgGs) behaved as agonists or even antagonists of TSH. In this paper we have looked for the existence of IgG preparations without any thyroid stimulatory activity but able to significantly block the action of TSH in 128 hyperthyroid Graves' patients. The presence of TSH-binding inhibiting antibodies (TBIAb) and that of thyroid stimulating antibodies (TSAb) was evaluated by a radioreceptor assay using solubilized thyroid plasma membranes and by assaying the adenylate cyclase (AC) function of thyroid plasma membranes, respectively. Seventeen IgGs were negative for TSAb but positive for TBIAb in the screening, using only one concentration of IgG. Three kinds of activity were investigated in these IgGs at different doses: (1) TSH-binding inhibiting activity; (2) thyroid AC stimulating activity; and (3) the inhibition of TSH-induced AC stimulation. The results showed that the level of activity was not always dose-dependent. A significant (greater than 20%) inhibition of the TSH-dependent AC stimulation was present in 15 of the 17 IgGs examined: this inhibition was more elevated at lower than at higher doses in two preparations. No significant correlation was found between the three activities. In short, we have been able to demonstrate the existence of 'blocking' antibodies, apparently without any stimulatory activity, in some patients with Graves' disease. The diphasic pattern of the dose-response curves of some IgGs and the lack of correlation between the different activities can be explained by the co-existence in the sera of Graves' patients of different autoantibodies varying in concentration, binding affinity constant and intrinsic biological activity.
Direct Preparation of Few Layer Graphene Epoxy Nanocomposites from Untreated Flake Graphite (2015)

The natural availability of flake graphite and the exceptional properties of graphene and graphene-polymer composites create a demand for simple, cost-effective, and scalable methods for top-down graphite exfoliation. This work presents a novel method of few layer graphite nanocomposite preparation directly from untreated flake graphite using a room temperature ionic liquid and laminar shear processing regimen. The ionic liquid serves both as a solvent and initiator for epoxy polymerization and is incorporated chemically into the matrix. This nanocomposite shows low electrical percolation (0.005 v/v) and low thickness (1-3 layers) graphite/graphene flakes by TEM. Additionally, the effect of processing conditions by rheometry and comparison with solvent-free conditions reveal the interactions between processing and matrix properties and provide insight into the theory of the chemical and physical exfoliation of graphite crystals and the resulting polymer matrix dispersion. An interaction model that correlates the interlayer shear physics of graphite flakes and processing parameters is proposed and tested.