gebhart/patrepeval huggingface dataset:
CD56+ AML Is Strongly Associated with AML1/ETO Rearrangement and CNS Involvement in Childhood AML. (2007)

Abstract Introduction: To investigate the clinical difference between CD56+AML and CD56−AML, we examined the incidence of CD56+AML and analyzed several clinical and biological characteristics, cytogenetic features, immunophenotypic features, and clinical prognosis of CD56+AML. Method: 213 patients (177 adults, 36 children) with de novo AML in Seoul National University Hospital were enrolled. FAB subtypes were 4 M0 (2.3%), 26 M1, (12.2%), 78 M2 (36.6%), 27 M3 (12.8%), 43 M4 (20.2%), 15 M5 (7.1%), 14 M6 (6.6%), and 5 M7 (2.4%). Immunophenotyping was performed by immunohistochemical stain or multiparameter flow cytometry. The association between CD 56 expression and variables (age, sex, WBC count, blast, cytogenetic features, extramedullary involvement, disease free survival, and overall survival) was analyzed by the fisher’s exact test, chi-square test and T test, and Kaplan-Meier method. All statistical calculation were performed using SPSS system. Results: CD56 was detected in 6 of 177 adults (3.4%) and in 9 (25.0%) of children, showing significantly higher in children group (p = 0.000). The CD56 expression was significantly frequent in M7 subtype (p=0.003). The other clinical characteristics, such as sex, WBC count, % blasts in peripheral blood was not significantly associated with CD56 positivity. Frequency of extramedullary involvement did not differ between CD56+AML and CD56−AML. However, the frequency of CNS involvement at initial diagnosis or relapse were significantly higher in CD56+AML (p=0.018). (Table 1) Among cytogenetic changes, AML1/ETO rearrangement was significantly associated with CD56 expression (p=0.024). Aberrant expression of one or more lymphoid markers was observed in 42.9% (6/15 CD56+AML) and 45.2% (80/198 CD56+AML), showing no difference between CD56+AML and CD56−AML. Median disease free survival was 7 months in CD56+AML and 19 months in CD56−AML, showing no significant difference in two groups (p=0.2466). Median overall survival was not reached in CD56+AML and 25 months in CD56−AML (p=0.1591). Conclusion: The incidence of CD56 positive AML was higher in childhood AML and association of CD56+AML with AML1/ETO rearrangement, CNS involvement and M7 subtype was observed, suggesting the different biologic behavior of CD56+AML. Furthermore, we suggest that 3rd lineage of leukemic cells, would be taken into consideration for the biphenotypic leukemia. Extramedullary involvement of CD56+ vs. CD56− CD56+ CD56- p * chi-square test or fisher’s exact test (level of significance: p&lt;0.05) n=15 (7.0%) n=198 (93.0%) Extramedullary involvement 3 (20.0%) 27 (13.6%) 0.450 Adult 0 19 Child 3 8 CNS involvement 3 (20.0%) 7 (3.5%) 0.025 Adult 0 4 Child 3 3
6.2 : Optimisation économique d’une installation d’extraction triphasique de polluants à partir d’une nappe phréatique (2000)

Perraut Laureen, Lecoffre Yves, Roudier Pascal. 6.2 : Optimisation économique d’une installation d’extraction triphasique de polluants à partir d’une nappe phréatique. In: Les logiciels de mécanique des fluides au service de l'industrie et de l'environnement. Congrès de la Société Hydrotechnique de France. 26èmes journées de l'hydraulique. Paris-Marne la Vallée, du 11 au 13 septembre 1998. 2000.
The Use of LMA in Newborn Resuscitation (1997)

INTRODUCTION At birth, numerous physiologic changes must occur for a fetus to successfully make the transition to a neonate. Despite the complexity of this process of adaptation to extrauterine life, of approximately 3.5 million babies born annually in the United States only 6% of newborns require advanced life support in the delivery rooms. 1 The support required increases to 80% among newborns who weigh less than 1500 grams. The American Heart Association guidelines for neonatal resuscitation recommend that positive pressure ventilation (PPV), when indicated, be administered by bag and mask. 1 In large university hospitals this task is usually fulfilled by neonatologists, who are present 24 hours a day. An obstetric anesthesia work force survey conducted by Hawkins et al., in 1992, found that anesthesiologists performed neonatal resuscitation in 4% of vaginal deliveries and 6% of cesarean deliveries. 2 In a 1991 survey of midwestern community hospitals routine involvement of anesthesia personnel in neonatal resuscitation was noted by 31 % of respondents. 3 RESUSCITATION OF A NEWBORN RESUSCITATION OF A NEWBORN CAN BE DIVIDED INTO 4 MAJOR STEPS 1. Initial stabilization and evaluation: This consists of drying, positioning the neonate under radiant warmer to minimize heat loss and suctioning of mouth and nose (racheal suctioning if meconium present). This should only take approximately 20 seconds
Photoacoustic Reconstruction Using Sparsity in Curvelet Frame. (2020)

We compare two approaches to photoacoustic image reconstruction from compressed/subsampled photoacoustic data based on assumption of sparsity in the Curvelet frame: DR, a two step approach based on the recovery of the complete volume of the photoacoustic data from the subsampled data followed by the acoustic inversion, and p0R, a one step approach where the photoacoustic image (the initial pressure, p0) is directly recovered from the subsampled data. For representation of the photoacoustic data, we propose a modification of the Curvelet transform corresponding to the restriction to the range of the photoacoustic forward operator. Both recovery problems are formulated in a variational framework. As the Curvelet frame is heavily overdetermined, we use reweighted l1 norm penalties to enhance the sparsity of the solution. The data reconstruction problem DR is a standard compressed sensing recovery problem, which we solve using an ADMM-type algorithm, SALSA. Subsequently, the initial pressure is recovered using time reversal as implemented in the k-Wave Toolbox. The p0 reconstruction problem, p0R, aims to recover the photoacoustic image directly via FISTA, or ADMM when in addition including a non-negativity constraint. We compare and discuss the relative merits of the two approaches and illustrate them on 2D simulated and 3D real data.
Movable Cross-Linked Polymeric Materials from Bulk Polymerization of Reactive Polyrotaxane Cross-Linker with Acrylate Monomers (2017)

Topological cross-linked polymers attract much attention from their unique mechanical properties derived from their cross-linking structure. Here, we have fabricated a polymeric material (Acryl-AcO-PRx) incorporating topological cross-links into various universal acrylate polymers by using a modified polyrotaxane as a polymerizable cross-linking agent. Acryl-AcO-PRx obtained by a simple photocuring technique under bulk conditions showed a distinctly higher extensibility compared with the chemical cross-linked polymers. In addition, Acryl-AcO-PRx materials showed high stress relaxation and deformation hysteresis. These results indicate that the topologically cross-linked structure composed of polyrotaxane plays an important role in mechanical properties even in bulk state.
A Consolidated Perspective on Multimicrophone Speech Enhancement and Source Separation (2017)

Speech enhancement and separation are core problems in audio signal processing, with commercial applications in devices as diverse as mobile phones, conference call systems, hands-free systems, or hearing aids. In addition, they are crucial preprocessing steps for noise-robust automatic speech and speaker recognition. Many devices now have two to eight microphones. The enhancement and separation capabilities offered by these multichannel interfaces are usually greater than those of single-channel interfaces. Research in speech enhancement and separation has followed two convergent paths, starting with microphone array processing and blind source separation, respectively. These communities are now strongly interrelated and routinely borrow ideas from each other. Yet, a comprehensive overview of the common foundations and the differences between these approaches is lacking at present. In this paper, we propose to fill this gap by analyzing a large number of established and recent techniques according to four transverse axes: 1) the acoustic impulse response model, 2) the spatial filter design criterion, 3) the parameter estimation algorithm, and 4) optional postfiltering. We conclude this overview paper by providing a list of software and data resources and by discussing perspectives and future trends in the field.
Pharmacokinetics of [14C] omeprazole in patients with impaired renal function (1986)

Pharmacokinetics of [14C]omeprazole and its metabolites were studied after single intravenous and oral doses of 20 and 40 mg, respectively, to 12 patients with chronic renal insufficiency. Blood samples for determination of total radioactivity, omeprazole, OH-omeprazole, sulfone, and sulfide were taken for 24 hours. Urine was collected over 96 hours for determination of total radioactivity and during the first 24 hours for additional assay of omeprazole and metabolites. The mean systemic availability was 70%. The mean plasma t1/2 of omeprazole was 0.6 hours. Unchanged omeprazole was not measurable in urine. Derived pharmacokinetic constants of intact omeprazole were within the range of those reported in healthy individuals. The accumulated 24-hour excretion of radioactive metabolites was related significantly to creatinine clearance. The cumulative excretion of total radioactivity in urine over 96 hours in percent of given dose varied between 25% and 83%.
Genetic Ablation of the Aryl Hydrocarbon Receptor Causes Cigarette Smoke-induced Mitochondrial Dysfunction and Apoptosis (2011)

Cigarette smoke is the primary risk factor for chronic obstructive pulmonary disease (COPD). Alterations in the balance between apoptosis and proliferation are involved in the etiology of COPD. Fibroblasts and epithelial cells are sensitive to the oxidative properties of cigarette smoke, and whose loss may precipitate the development of COPD. Fibroblasts express the aryl hydrocarbon receptor (AhR), a transcription factor that attenuates pulmonary inflammation and may also regulate apoptosis. We hypothesized the AhR would prevent apoptosis caused by cigarette smoke. Using genetically deleted in vitro AhR expression models and an established method of cigarette smoke exposure, we report that AhR expression regulates fibroblasts proliferation and prevents morphological features of apoptosis, including membrane blebbing and chromatin condensation caused by cigarette smoke extract (CSE). Absence of AhR expression results in cleavage of PARP, lamin, and caspase-3. Mitochondrial dysfunction, including cytochrome c release, was associated with loss of AhR expression, indicating activation of the intrinsic apoptotic cascade. Heightened sensitivity of AhR-deficient fibroblasts was not the result of alterations in GSH, Nrf2, or HO-1 expression. Instead, AhR(-/-) cells had significantly less MnSOD and CuZn-SOD expression, enzymes that protects against oxidative stress. The ability of the AhR to suppress apoptosis was not restricted to fibroblasts, as siRNA-mediated knockdown of the AhR in lung epithelial cells also increased sensitivity to smoke-induced apoptosis. Collectively, these results suggest that cigarette smoke induced loss of lung structural support (i.e. fibroblasts, epithelial cells) caused by aberrations in AhR expression may explain why some smokers develop lung diseases such as COPD.
Differentiation of Lactobacillus isolates from infant faeces by SDS-PAGE and rRNA-targeted oligonucleotide probes (1999)

Isolates of lactobacilli from infant faeces phenotypically characterized as Lactobacillus paracasei subsp. paracasei (six strains), Lact. rhamnosus (six strains), Lact. gasseri (three strains), Lact. acidophilus (one strain) and Lact. fermentum/reuteri (three strains) according to recent classification systems were subjected to SDS-PAGE of whole cell proteins and rRNA-targeted oligonucleotide probe hybridization, in order to confirm the phenotypic characterization and elucidate the exact taxonomic position of the three strains that had properties between fermentum and reuteri. Results suggested a good agreement between the phenotypic characterization, SDS-PAGE and rRNA-targeted oligonucleotide probe hybridization for strains of all species except for the Lact. fermentum/reuteri strains. Results obtained by rRNA probes suggested a possible phylogenetic relatedness of the strains to Lact. reuteri. Isolates from infant faeces with interesting probiotic properties could be used as components of fermented milk products.
Amphiphilic derivatives of betaine esters as modifiers of macrovesicular BLM. (1989)

A series of amphiphilic derivatives of betaine esters (V-n), with the chemical structure (CH3)3N+COOCnH2n + 1Cl- (n = 10, 12, 14 or 16) were studied with respect to their effects on the electrical properties of lecithin macrovesicular membranes. Normalized resistance and breakdown voltage were found to depend on the V-n concentration in the membrane and on the alkyl chain length (n). Resistance decreases up to about 10(4) ohm.cm2 and breakdown voltage decreases by 111 mV were detected in the V-n: lecithin molar ratio range measured (0.005-0.05). Maximal decrease in breakdown voltage was observed for V-14. These findings together with the featured anionic selectivity suggest that, due to the interaction of V-n with phospholipids, hydrophilic pores are formed in the lipid bilayers. This assumption is supported by the results obtained by electron paramagnetic resonance (EPR) measurements which showed no collective changes in bilayer dynamics or ordering. In particular, rotational correlation times and order parameters of the spin probe molecules dissolved in the membrane did not change in the concentration range tested. Since a large number of defects in the membrane can be expected to influence the collective ordering and dynamics, this observation also suggest that the number of pores formed is small.
Sulfonation of catechin (1972)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSulfonation of catechinKarl D. SearsCite this: J. Org. Chem. 1972, 37, 22, 3546–3547Publication Date (Print):November 1, 1972Publication History Published online1 May 2002Published inissue 1 November 1972https://pubs.acs.org/doi/10.1021/jo00795a037https://doi.org/10.1021/jo00795a037research-articleACS PublicationsRequest reuse permissionsArticle Views177Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A distributed collision avoidance protocol using pilot tone-based carrier sense mechanism for passive optical networks (2004)

A distributed collision-avoidance scheme employing pilot-tone based carrier sensing mechanism is proposed for the upstream multiaccess in PONs. Simulation results show the proposed algorithm outperforms the conventional CSMA/CD scheme in terms of network throughput and delay.
A Comparison of Total Hip Arthroplasty and Hemiarthroplasty for Treatment of Acute Fracture of the Femoral Neck (1992)

One hundred sixty-six acute, nonpathologic displaced femoral neck fractures in elderly patients were treated with either unipolar hemiarthroplasty (122 operations; 77 cemented, 45 uncemented) or total hip arthroplasty (THA) (44 operations; all cemented). The average age, (75.2 years of age in the THA group 76.2 years of age in the hemiarthroplasty group), anesthesia risk classification, in-hospital mortality, early complications, and dislocation rates were comparable in each treatment group. In an average long-term follow-up period of 56 months, pain, walking, and function scores were higher with THA than with cemented or uncemented hemiarthroplasty. Revision rates were 2.2% after THA, versus 7.9% for cemented hemiarthroplasty and 13% for uncemented hemiarthroplasty. Hemiarthroplasty is recommended for the older patient, who may be occasionally active outside of the household. The healthy, active patient, however, may benefit from THA rather than hemiarthroplasty.
A Role for Double-Stranded RNA-Activated Protein Kinase PKR in Mycobacterium-Induced Cytokine Expression (2005)

Following infection of the host by Mycobacterium tuberculosis, induction of cytokines is a major defense mechanism to limit the pathogen invasion. Cytokines interact with each other to form an intertwined network of pathways. For example, IFN and TNF have been shown to interact through common pathways including IFN-inducible, dsRNA-activated serine/threonine protein kinase (PKR) induction. As a signal transducer, it has been conventionally known to regulate the induction of cytokine expression in response to virus infection through NF-kappaB. In light of the critical role of TNF in immunity and its cytotoxic effects mediated by PKR, we examined the role of the kinase in the regulation of immune response against M. tuberculosis using the interaction of bacillus Calmette-Guérin (BCG) and primary human blood monocytes as a model. Our results showed that BCG stimulates the induction of cytokine expression in human primary blood monocytes including TNF-alpha, IL-6, and IL-10. With the suppression of PKR by using PKR-mutant gene or 2-aminopurine as PKR inhibitor, we showed that the BCG-induced cytokine expression in human monocytes is regulated by the phosphorylation and activation of PKR. We also demonstrated that downstream of PKR induction is the activation of MAPK and translocation of NF-kappaB into the nucleus. NF-kappaB in turn mediates the transcription of specific cytokine genes. Taken together, PKR plays a critical role in the regulation of immune responses to mycobacterial infection and may serve as an important molecule in the innate antimycobacterial defense.
Effect of Ce2O3, La2O3and ZnO additives on the oxygenates conversion into liquid hydrocarbons (2018)

A selective modifying effect of cerium, magnesium and zinc oxide additives on the activity and the selectivity of a pentasil group zeolite catalyst in the reaction of conversion of oxygenates (methanol and dimethyl ether) to liquid hydrocarbons was found. It was found that zinc oxide contributes to the stable operation of the zeolite catalyst in the conversion of oxygenates in the synthesis gas stream and leads to the production of gasolines with low durene content (not more than 6.1 wt%). The obtained results demonstrate the rationale for producing hydrocarbons from synthesis gas without the stage of oxygenate separation with their subsequent conversion to synthetic gasoline.
Penguin colonies as secondary sources of contamination with persistent organic pollutants (2007)

Although long-range atmospheric transport has been described as the predominant mechanism for exposing polar regions to persistent organic pollutants (POPs), recent studies have suggested that bird activity can also contribute substantially to contaminant levels in some environments. However, because the species so far reported have all been migratory, it has not been demonstrated conclusively whether locally elevated contamination represents transport from lower latitudes by the migrating birds or, alternatively, redistribution and concentration of contaminants that were already present in the high-latitude environments. The present study demonstrates, for the first time, that several POPs are present in elevated concentrations in an environment frequented by a non-migratory species (Adélie penguins) that spends its entire life in the Antarctic. Levels of POPs, such as p,p'-DDE, hexachlorobenzene (HCB), chlordanes (CHLs) and polychlorinated biphenyls (PCBs), were 10 to 100-fold higher in soil samples from penguin colonies than from reference areas. This significant difference is likely related to local penguin activity, such as a higher abundance of guano and the presence of bird carcasses. This hypothesis is also supported by a higher percentage of persistent congeners (PCB 99, 118, 138 and 153) in the soil from the colonies compared to the reference areas. This profile of PCB congeners closely matched profiles seen in penguin eggs or penguin blood.
Purification and characterization of a keratinase from the feather-degrading cultures of Aspergillus flavipes (2012)

Keratinase was purified and characterized from the solid cultures of Aspergillus flavipes using chicken feather as substrate under solid state fermentation. The enzyme was purified by about 2.67 fold compared to the crude enzyme preparation. 40-60% ammonium sulphate saturation was used followed by anion exchange chromatography and gel filtration. The molecular weight of the enzyme under denaturing conditions was 60 KDa. The optimum pH and pH stability range were 7.0 and 5-8, respectively. The enzyme activity was significantly inhibited by incubating with EDTA, Hg +2 , Fe +3 , while it was not apparently affected by the presence of Zn +2 , Mg +2 and Cu +2 . The enzyme has a wide proteolytic activity towards casein, albumin and gelatin, related to the standard keratin, which makes their wide biotechnological applications justifiable. Key words: Keratinase, Aspergillus flavipes , solid state fermentation.
Poly(ADP-ribose) polymerase inhibition reveals a potential mechanism to promote neuroprotection and treat neuropathic pain (2016)

Neuropathic pain is triggered by the lesions to peripheral nerves which alter their structure and function. Neuroprotective approaches that limit the pathological changes and improve the behavioral outcome have been well explained in different experimental models of neuropathy but translation of such strategies to clinics has been disappointing. Experimental evidences revealed the role of free radicals, especially peroxynitrite after the nerve injury. They provoke oxidative DNA damage and consequent over-activation of the poly(ADP-ribose) polymerase (PARP) upregulates pro-inflammatory pathways, causing bioenergetic crisis and neuronal death. Along with these changes, it causes mitochondrial dysfunction leading to neuronal apoptosis. In related preclinical studies agents that neutralize the free radicals and pharmacological inhibitors of PARP have shown benefits in treating experimental neuropathy. This article reviews the involvement of PARP over-activation in trauma induced neuropathy and therapeutic significance of PARP inhibitors in the experimental neuropathy and neuropathic pain.