gebhart/patrepeval huggingface dataset:
ChemInform Abstract: Conformation and Facial Selectivities of Chiral Six‐Membered 1,3‐ Diheterocycles Involving an Enone Function (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Marketing in a local authority (1995)

Considers the role of marketing in an increasingly profit‐oriented local authority. Discusses the problems involved when a public service espouses marketing principles, but concludes that only marketing can make most effective use of the scarce resources available to local authorities.
Reviewer acknowledgement 2014 (2014)

The Editors of Human Genomics would like to thank all our reviewers who have contributed to the journal in volume 7 (2013).
Partial Reconstruction of Flavonoid and Isoflavonoid Biosynthesis in Yeast Using Soybean Type I and Type II Chalcone Isomerases (2005)

Flavonoids and isoflavonoids are major plant secondary metabolites that mediate diverse biological functions and exert significant ecological impacts. These compounds play important roles in many essential physiological processes. In addition, flavonoids and isoflavonoids have direct but complex effects on human health, ranging from reducing cholesterol levels and preventing certain cancers to improving women's health. In this study, we cloned and functionally characterized five soybean (Glycine max) chalcone isomerases (CHIs), key enzymes in the phenylpropanoid pathway that produces flavonoids and isoflavonoids. Gene expression and kinetics analysis suggest that the soybean type I CHI, which uses naringenin chalcone as substrate, is coordinately regulated with other flavonoid-specific genes, while the type II CHIs, which use a variety of chalcone substrates, are coordinately regulated with an isoflavonoid-specific gene and specifically activated by nodulation signals. Furthermore, we found that some of the newly identified soybean CHIs do not require the 4'-hydroxy moiety on the substrate for high enzyme activity. We then engineered yeast (Saccharomyces cerevisiae) to produce flavonoid and isoflavonoid compounds. When one of the type II CHIs was coexpressed with an isoflavone synthase, the enzyme catalyzing the first committed step of isoflavonoid biosynthesis, various chalcone substrates added to the culture media were converted to an assortment of isoflavanones and isoflavones. We also reconstructed the flavonoid pathway by coexpressing CHI with either flavanone 3beta-hydroxylase or flavone synthase II. The in vivo reconstruction of the flavonoid and isoflavonoid pathways in yeast provides a unique platform to study enzyme interactions and metabolic flux.
Cold Adaptation of a Mesophilic Subtilisin-like Protease by Laboratory Evolution (2000)

Enzymes isolated from organisms native to cold environments generally exhibit higher catalytic efficiency at low temperatures and greater thermosensitivity than their mesophilic counterparts. In an effort to understand the evolutionary process and the molecular basis of cold adaptation, we have used directed evolution to convert a mesophilic subtilisin-like protease from Bacillus sphaericus, SSII, into its psychrophilic counterpart. A single round of random mutagenesis followed by recombination of improved variants yielded a mutant, P3C9, with a catalytic rate constant (k(cat)) at 10 degrees C 6.6 times and a catalytic efficiency (k(cat)/K(M)) 9.6 times that of wild type. Its half-life at 70 degrees C is 3.3 times less than wild type. Although there is a trend toward decreasing stability during the progression from mesophile to psychrophile, there is not a strict correlation between decreasing stability and increasing low temperature activity. A first generation mutant with a >2-fold increase in k(cat) is actually more stable than wild type. This suggests that the ultimate decrease in stability may be due to random drift rather than a physical incompatibility between low temperature activity and high temperature stability. SSII shares 77. 4% identity with the naturally psychrophilic protease subtilisin S41. Although SSII and S41 differ at 85 positions, four amino acid substitutions were sufficient to generate an SSII whose low temperature activity is greater than that of S41. That none of the four are found in S41 indicates that there are multiple routes to cold adaptation.
Localization of Multiple Power Line Insulators Based on Shape Feature Points and Equidistant Model in Aerial Images (2018)

Insulators are important equipments on the power transmission line, and the failure may cause severe influences to power system. So localizing insulators in aerial image to avert further damage is an important research topic for automatic fault diagnosis. In order to localize multiple insulators with variant directions in aerial image, this paper proposes a novel method to extract shape points, summarizes and utilizes the in-a-line constraint and equidistant constraint of shape feature points, and proposes a localization method of insulators based on shape points and equidistant model. The localization method extracts shape points, detects the possible direction of insulators based on in-a-line constraint by RANdom SAmple Consensus (RANSAC), proposes the equidistant model to obtain the positive points of insulator, and localizes insulators in aerial image effectively. Compared with other methods, the proposed method is 3 times faster than previous methods, and can obtained 33.85% more efficient points. Experimental results show that the proposed method achieves favorable effects in the localization of insulators in real aerial images.
Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction. (1997)

The NF-AT family of transcription factors participates in the regulation of early immune response genes such as IL-2, IL-4, CD40 ligand, and Fas ligand in response to Ca2+/calcineurin signals initiated at the antigen receptor. Calcineurin activation leads to the rapid translocation of NF-AT family members from cytoplasm to nucleus, an event that is blocked by the immunosuppressive drugs cyclosporin A and FK506. We show that translocation requires two redundant nuclear localization sequences and that one sequence is in an intramolecular association with phosphorserines in a conserved motif located at the amino terminus of each NF-AT protein. Mutation of serines in this motif in NF-ATc both disrupts this intramolecular interaction and leads to nuclear localization, suggesting a model of NF-AT nuclear import in which dephosphorylation by calcineurin causes exposure of two nuclear localization sequences.
Modulation of Respiratory Burst Activity and Mitogenic Response of Human Peripheral Blood Mononuclear Cells and Murine Splenocytes and Peritoneal Cells by Malathion (1990)

Modulation of Respiratory Burst Activity and Mitogenic Response of Human Peripheral Blood Mononuclear Cells and Murine Splenocytes and Peritoneal Cells by Malathion. RODGERS, K. E., AND ELLEFSON, D. D. (1990). Fundam. Appl. Toxicol. 14, 309–317. Previous studies showed that acute administration of noncholinergic doses of malathion In vivo elevated the humoral immune and mitogenic responses but did not alter the generation of the cytotoxic T lymphocyte (CTL) response to alloantigen of splenocytes from treated mice. However, in vitro exposure to malathion suppressed the generation of a CTL response. In this study, the effects of In vivo and in vitro (with and without an NADPH-regenerating liver enzyme system) exposure to malathion on the mitogenic responses of murine splenocytes or respiratory burst activity of peritoneal cells were examined. The effect of in vitro exposure to malathion on the ability of human peripheral blood mononuclear cells (PBMC) to perform these functions was also examined. In vivo exposure to malathion significantly elevated proliferative responses of murine splenocytes to mitogens. Cell separation and reconstitution studies indicated that adherent splenocytes from treated mice could elevate the proliferative responses of nonadherent splenocytes from control mice. Alternatively, in vitro exposure of murine splenocytes or human PBMC to malathion or malathion metabolized by a liver enzyme system suppressed or did not change, respectively, the proliferative responses to mitogens. In addition, cell separation and reconstitution experiments indicated that in vitro exposure to malathion affected nonadherent splenocytes and PBMC. In vivo exposure to malathion also elevated the production of hydrogen peroxide, following stimulation with phorbol myristate acetate, by murine peritoneal cells. In vivo exposure of murine peritoneal cells to malathion suppressed or elevated the respiratory burst activity following exposure to malathion or malathion metabolized by a liver enzyme system, respectively. Exposure of human PBMC to metabolized malathion in vitro enhanced their ability to produce hydrogen peroxide.
Low-Temperature Crystallization of Barium Ferrite Nanoparticles by a Sodium Citrate-Aided Synthetic Process (2007)

This article describes the synthesis of barium ferrite nanoparticles at low crystallization temperatures using a sodium citrate-aided process. Monodispersed barium ferrite amorphous nanoparticles were synthesized by the formation of metal−citrate complexes at pH 10, followed by hydrolysis at 100 °C. The mean particle diameter was 4.7 nm with a specific surface area of 137.8 m2/g. This is the first time that sodium citrate has been used as a chelating agent in the synthesis of barium ferrite nanoparticles. Sodium citrate plays two important roles in the process: it allows the homogeneous mixing of two metal cations in the as-synthesized barium ferrite amorphous nanoparticles, and it retards particle growth via the formation of surface citrate complexes, inhibiting the agglomeration of the nanoparticles. The amorphous precursor nanoparticles were transformed into a hexagonal structure by calcination at elevated temperatures (500−750 °C) in air. XRD patterns showed that the amorphous phase of the nanoparticles was completely transformed to the hexagonal phase after calcination at 600 °C for 100 min, with no intermediate phase evident. This crystallization temperature was lower than previously reported crystallization temperatures. Crystallization behavior was examined using thermal analysis and FTIR measurements. Particle size, measured from SEM images, was increased from 35 to 130 nm by elevating the calcination temperature from 600 to 750 °C. Barium ferrite nanoparticles calcinated at 600 °C had high magnetic properties: the coercivity and saturation magnetization values were 3580 Oe and 43 emu/g, respectively.
Pervious Concrete Mix Design for Wearing Course Applications (2009)

Portland cement pervious concrete (PCPC) has shown great potential to reduce roadway noise, improve splash and spray, and to improve friction as a surface wearing course. This paper presents the results of studies conducted at Iowa State University and the National Concrete Pavement Technology Center (CP Tech Center) to develop mix designs and procedures for the use of PCPC overlays for highway applications. Issues related to characterization of workability, the need for air entrainment and the effect of air entrainment on durability, the development of design mixture proportions for mechanized placement, the evaluation of the curing requirements for surface abrasion resistance, and the development of overlay design procedures are presented and discussed. The results of these studies show that effective PCPC overlays can be designed for wearing course applications.
Efficacy and Safety of Memantine in Patients With Mild to Moderate Vascular Dementia (2002)

In patients with mild to moderate vascular dementia, memantine 20 mg/d improved cognition consistently across different cognitive scales, with at least no deterioration in global functioning and behavior. It was devoid of concerning side effects.
NiMn-pinned spin valves with high pinning field made by ion beam sputtering (1996)

Spin valves of film layer structure, Ta/NiMn/NiFe/Co/Cu/Co/NiFe/Ta/Substrate were fabricated by ion beam sputtering. Optimization of the processes of deposition and posthermal treatment yields highly (111) oriented spin valve films with a giant-magnetoresistance ratio of above 4% and pinning field of 650 Oe. This is the strongest pinning field ever observed. It stays constant up to 180 °C, then decreases to zero at a blocking temperature of 380 °C. These spin valves are highly thermally stable and, thus, suitable for the application of high density recording heads.
A study of the online profile of enterprise users in professional social networks (2014)

Understanding the impact of corporate information publicly distributed on the Web is becoming more and more crucial. In this paper we report the result of a study that involved 130 IBM employees: we explored the correctness and extent of organisational information that can be observed from the online profiles of a company's employees. Our work contributes new insights to the study of social networks by showing that, even by considering a small fraction of the available online data, it is possible to discover accurate information about an organisation, its structure, and the factors that characterise the social reach of their employees.
Partial purification and substrate specificity of a ubiquitin hydrolase from Saccharomyces cerevisiae (1991)

A ubiquitin hydrolase that removes ubiquitin from a multi-ubiquitinated protein has been purified 600-fold from Saccharomyces cerevisiae. Four different ubiquitin-protein conjugates were assayed as substrates during the purification procedure. Enzymic activities that removed ubiquitin from ubiquitinated histone H2A, a ubiquitin-ubiquitin dimer and a ubiquitin-ribosomal fusion protein were separated during the purification from an activity that removed a single ubiquitin molecule linked by an isopeptide bond to a ubiquitinated protein. The size of the native enzyme was 160 kDa, based on its sedimentation in a sucrose gradient, and the subunit molecular mass was estimated to be 160 kDa, based on a profile of proteins eluted in different fractions by thiol-affinity chromatography. The partially purified hydrolase was not inhibited by a variety of protease inhibitors, except for thiol-blocking reagents. The natural substrate for this enzyme may be the polyubiquitin chain containing ubiquitin molecules bound to each other in isopeptide bonds, with one of them linked to a lysine residue of a protein targeted for intracellular proteolysis.
Systemic Markers of Interferon-γ–Mediated Immune Activation and Long-Term Prognosis in Patients With Stable Coronary Artery Disease (2010)

In patients with stable angina pectoris, systemic markers of IFN-γ activity, plasma neopterin, and plasma KTR provide similar risk estimates for MCE and mortality. Our results support experimental data linking IFN-γ to acute atherosclerotic complications.
Smartphone-Based Mobile Detection Platform for Molecular Diagnostics and Spatiotemporal Disease Mapping (2018)

Rapid and quantitative molecular diagnostics in the field, at home, and at remote clinics is essential for evidence-based disease management, control, and prevention. Conventional molecular diagnostics requires extensive sample preparation, relatively sophisticated instruments, and trained personnel, restricting its use to centralized laboratories. To overcome these limitations, we designed a simple, inexpensive, hand-held, smartphone-based mobile detection platform, dubbed "smart-connected cup" (SCC), for rapid, connected, and quantitative molecular diagnostics. Our platform combines bioluminescent assay in real-time and loop-mediated isothermal amplification (BART-LAMP) technology with smartphone-based detection, eliminating the need for an excitation source and optical filters that are essential in fluorescent-based detection. The incubation heating for the isothermal amplification is provided, electricity-free, with an exothermic chemical reaction, and incubation temperature is regulated with a phase change material. A custom Android App was developed for bioluminescent signal monitoring and analysis, target quantification, data sharing, and spatiotemporal mapping of disease. SCC's utility is demonstrated by quantitative detection of Zika virus (ZIKV) in urine and saliva and HIV in blood within 45 min. We demonstrate SCC's connectivity for disease spatiotemporal mapping with a custom-designed website. Such a smart- and connected-diagnostic system does not require any lab facilities and is suitable for use at home, in the field, in the clinic, and particularly in resource-limited settings in the context of Internet of Medical Things (IoMT).
A web-based remote radiation treatment planning system using the remote desktop function of a computer operating system: a preliminary report (2009)

We developed a web-based, remote radiation treatment planning system which allowed staff at an affiliated hospital to obtain support from a fully staffed central institution. Network security was based on a firewall and a virtual private network (VPN). Client computers were installed at a cancer centre, at a university hospital and at a staff home. We remotely operated the treatment planning computer using the Remote Desktop function built in to the Windows operating system. Except for the initial setup of the VPN router, no special knowledge was needed to operate the remote radiation treatment planning system. There was a time lag that seemed to depend on the volume of data traffic on the Internet, but it did not affect smooth operation. The initial cost and running cost of the system were reasonable.
Potentiation by glutamic acid dimethyl ester of GLP-1 insulinotropic action in fed anaesthetized rats (2001)

The dimethyl ester of L-glutamic acid (DMG) stimulates insulin release and was proposed as a possible insulinotropic tool in the treatment of non-insulin-dependent diabetes. In such a perspective, it was investigated whether DMG enhances the B-cell secretory response to GLP-1 in fed anaesthetized rats. The primed constant infusion of DMG (1.0 micromol and then 0.5 micromol/min, both per g body wt.) provoked a rapid and sustained increase in plasma insulin concentration and augmented the release of insulin caused by GLP-1. Thus, DMG indeed appears as a suitable tool to potentiate the insulinotropic action of GLP-1.
Loss of p 21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm -deficient mice (1997)

Ataxia telangiectasia (AT) is an autosomal recessive disorder characterized by growth retardation, cerebellar ataxia, oculocutaneous telangiectasias, and a high incidence of lymphomas and leukemias. In addition, AT patients are sensitive to ionizing radiation. Atm-deficient mice recapitulate most of the AT phenotype. p21(cip1/waf1 )(p21 hereafter), an inhibitor of cyclin-dependent kinases, has been implicated in cellular senescence and response to gamma-radiation-induced DNA damage. To study the role of p21 in ATM-mediated signal transduction pathways, we examined the combined effect of the genetic loss of atm and p21 on growth control, radiation sensitivity, and tumorigenesis. As might have been expected, our data provide evidence that p21 modifies the in vitro senescent response seen in AT fibroblasts. Further, it is a downstream effector of ATM-mediated growth control. In addition, however, we find that loss of p21 in the context of an atm-deficient mouse leads to a delay in thymic lymphomagenesis and an increase in acute radiation sensitivity in vivo (the latter principally because of effects on the gut epithelium). Modification of these two crucial aspects of the ATM phenotype can be related to an apparent increase in spontaneous apoptosis seen in tumor cells and in the irradiated intestinal epithelium of mice doubly null for atm and p21. Thus, loss of p21 seems to contribute to tumor suppression by a mechanism that operates via a sensitized apoptotic response. These results have implications for cancer therapy in general and AT patients in particular.
The core design procedure SA V 90 for pressurized water reactors / Das Kernauslegungsverfahren SA V 90 für Druckwasserreaktoren. (1992)

Article The core design procedure SA V 90 for pressurized water reactors / Das Kernauslegungsverfahren SA V 90 für Druckwasserreaktoren. was published on January 1, 1992 in the journal Kerntechnik (volume 57, issue 1).
Mechanisms of MyD88- and TRIF-dependent downregulation of the glucocorticoid induced leucine zipper (GILZ) in macrophages � mRNA destabilization vs. microRNAs (2013)

Frontiers Events is a rapidly growing calendar management system dedicated to the scheduling of academic events. This includes announcements and invitations, participant listings and search functionality, abstract handling and publication, related events and post-event exchanges. Whether an organizer or participant, make your event a Frontiers Event!
The Development and Test of a Device for the Reconstruction of 3-D Position and Orientation by Means of a Kinematic Sensor Assembly With Rate Gyroscopes and Accelerometers (2005)

In this paper, we propose a device for the Position and Orientation (P&O) reconstruction of human segmental locomotion tasks. It is based on three mono-axial accelerometers and three angular velocity sensors, geometrically arranged to form two orthogonal terns. The device was bench tested using step-by-step motor-based equipment. The characteristics of the six channels under bench test conditions were: crosstalk absent, non linearity < +/- 0.1% fs, hysteresis < 0.1% fs, accuracy 0.3% fs, overall resolution better than 0.04 deg/s, 2 x g x 10(-4). The device was validated with the stereophotogrammetric body motion analyzer during the execution of three different locomotion tasks: stand-to-sit, sit-to-stand, gait-initiation. Results obtained comparing the trajectories of the two methods showed that the errors were lower than 3 x 10(-2) m and 2 deg during a 4s of acquisition and lower than 6 x 10(-3) m and 0.2 deg during the effective duration of a locomotory task; showing that the wearable device hereby presented permits the 3-D reconstruction of the movement of the body segment to which it is affixed for time-limited clinical applications.
Electron Microscopy Investigation of Structural Transformation of Carbon Black under Influence of High-Energy Electron Beam (2015)

Nanocapsules and stacks of graphene sheets have been prepared from carbon black by irradiation relativistic electron beam. Electrons with energy of 2.5 MeV were used in these experiments to produce carbon nanoparticles with graphite-like structure of the graphene layers. High Resolution Transmission Electron Microscopy (HRTEM), Raman spectroscopy and Electron Spin Resonance (ESR) spectroscopy were used to obtain the information about morphology, crystallinity, and interlayer distance of these nanostructures.