gebhart/patrepeval huggingface dataset:
Managing the Effects of Layoffs on Survivors (1992)

The productivity and morale of employees who survive layoffs are likely to have a major impact on the future performance of the corporation. The most important factors that affect survivors' reactions are: the fairness of the layoff and how it was handled; and changes within the organization that often accompany layoffs, such as job insecurity, career prospects, quantity and quality of new job responsibilities, and information about the reactions of one's fellow survivors. This article offers a series of steps that managers can take before, during, and after the layoffs to maximize the productivity and morale of survivors.
Antennenkonfigurationen und Kalibrierungskonzepte für die Realisierung reziproker Mehrantennensysteme (2005)

It is expected that wireless communication systems demand data rates up to 1 Gb/s in the near future. This technological challenge can be met by the further increase of the spectral efficiency or by the exploitation of previously unused frequency bands in the micro- or millimeterwave range. For that purpose multiple antenna techniques with array antennas at the transmitting and receiving side (MIMO systems) are the key technology. These techniques enable the additional use of spatial diversity and the implementation of spatial multiple access respectively of spatial multiplexing: The utilization of spatial diversity increases the transmission quality and hence the coverage for given bandwidth and transmission power. On the other hand the spatial multiplexing enables the use of higher data rates for fixed bandwidth and power. Both, the investigation of the information theory for multiple antenna and the development of signal processing algorithms, require the knowledge and modeling of the radio channel, which is influenced by the used antenna arrangements and is affected by transceiver impairments in real systems. In this dissertation the description of antenna configurations with respect to antenna polarization and antenna coupling is elaborated at first. Furthermore different antenna configurations are evaluated in terms of the obtainable channel capacity. It is figured out that the application of dual-polarized antennas is advantageous in particular for compact antenna arrangements. Whereas the use of small antenna arrays consisting of equal elements can decrease channel capacity strongly. In the next step, the description of the radio channel is extended by modeling the linear impairments of the transceiver frontends like matching and unequal gains. The resulting entire system model allows the implementation of realistic link level simulations for different wireless transmission techniques. Here only linear receive and transmit filters are analyzed. The suggested transmit filters require perfect channel knowledge at the transmitter, which is obtained in a TDD system by the utilization of the assumed reciprocity of the radio channel: For a reciprocal system the transmit and the receive channel are the same. To achieve reciprocity for the entire channel, including antennas and transceivers, a calibration of the system is necessary. Therefore different calibration methods are developed and evaluated. At least the calibration of that side, which uses the transmit filter, is required. It is shown, that on realistic conditions the calibration can be performed only for systems applying more transmit than receive antennas. The work concludes with the presentation of high frequency circuits implementing the proposed calibration methods.
Global stochastic optimization in hierarchical modeling of ligand/protein binding profiles (2000)

We present a detailed explanation of a mathematical method and numerical technique applied to solve an irregular non‐linear fitting problem that results from attempts to model the calorimetric profiles generated by the binding of phenolic ligands to the insulin hexamer. The method employed uses a non‐traditional approach to modeling data. Rather than start with a simplified model, we use a hierarchical tree of physical models with different degrees of sophistication. Starting with the model of highest dimension, we work our way to an optimum model which is of a lower dimension and is less complex. The algorithm uses two complementary techniques. First, a sensitivity analysis in the vicinity of the optimal point for each model is used to estimate errors in the parameters; that, in turn, provides the user with insight for model simplification. Second, we utilize the optimized model in the prediction of new experimental curves. The core of the method combines a strategy based on the proper split of the initial global numerical task into three locally independent subtasks, and induces a specific split in the search space. The application of three different optimization techniques (two parametric and one variational) with an alternating objective function defined in corresponding subspaces, in combination with the search along the hierarchical tree of mathematical models, enables us to overcome difficult computational problems, including over‐parametrization. We have obtained very accurate fits to a number of calorimetric curves, resulting in a quantitative description of intrinsic functional (free ligand concentration) and vector (equilibrium coefficients and enthalpies of binding) parameters. These quantitative results can now be used to improve the stability of insulin formulations. We believe that, with small modifications to the model, the method and algorithms presented in this article can be applied to other protein‐ligand systems.
LLNL Mercury Project Trinity Open Science Final Report (2016)

The Mercury Monte Carlo particle transport code developed at Lawrence Livermore National Laboratory (LLNL) is used to simulate the transport of radiation through urban environments. These challenging calculations include complicated geometries and require significant computational resources to complete. As a result, a question arises as to the level of convergence of the calculations with Monte Carlo simulation particle count. In the Trinity Open Science calculations, one main focus was to investigate convergence of the relevant simulation quantities with Monte Carlo particle count to assess the current simulation methodology. Both for this application space but also of more general applicability, we also investigated the impact of code algorithms on parallel scaling on the Trinity machine as well as the utilization of the Trinity DataWarp burst buffer technology in Mercury via the LLNL Scalable Checkpoint/Restart (SCR) library.
Glycine Antagonist (GV150526) in Acute Stroke: A Multicentre, Double-Blind Placebo-Controlled Phase II Trial (2001)

GV150526 is a novel glycine antagonist at the NMDA receptor complex. It is a potent neuroprotective agent in animal models of acute stroke including permanent middle cerebral artery occlusion in the rat. GV150526 was very well tolerated in early human studies. The purpose of this randomised, double-blind, multicentre, placebo-controlled trial was to assess the safety and population pharmacokinetics of GV150526 in patients with a clinical diagnosis of acute stroke. Exploratory assessment of efficacy, quality of life and resource utilisation was also undertaken. Upon clinical diagnosis of acute stroke within 12 h of onset of symptoms, patients were treated with a loading dose of 800 mg GV150526 (or placebo), followed by 5 maintenance doses of 400 mg GV150526 (or placebo) given every 12 h over 3 days. Following observation of asymptomatic hyperbilirubinaemia, the maintenance dose was reduced mid-study to 200 mg. CT/MRI scanning was not mandatory prior to treatment. The study treated 128 patients (38 with GV 800 mg/400 mg, 48 with GV 800 mg/200 mg and 42 with placebo). Fewer patients with mild stroke (NIH scores < or =5) were enrolled in the GV150526-treated groups than in the placebo group (placebo 38%, GV 800 mg/400 mg 18%, GV 800 mg/200 mg 15%). There was also an imbalance in the proportion of patients with haemorrhagic strokes (placebo 5%, GV 800 mg/400 mg 3%, GV 800 mg/200 mg 15%). Mortality at 1 month was unbalanced between treatment groups, being 10, 18 and 17% in the placebo, GV 800 mg/400 mg and GV 800 mg/200 mg groups, respectively (no significant difference). Similarly, adverse events, though consistent with an acute stroke population, appeared more often in the GV 800 mg/200 mg group. Functional outcomes at 1 month also showed imbalances, the percentage of patients with a Barthel Index score of > or =95 at 1 month being 52, 39 and 27% in the placebo, GV 800 mg/400 mg and GV 800 mg/200 mg groups, respectively. These results probably reflect a prognostically significant baseline difference between the groups rather than the effect of GV150526. GV150526 was generally well tolerated in patients with a clinical diagnosis of acute stroke and formal efficacy studies were considered justified.
Alternative Synthesis of a Dialkylimidazolium Tetrafluoroborate Ionic Liquid Mixture and its Use in Poly(acrylonitrile-butadiene) Hydrogenation (2002)

An alternative synthesis of a dialkylimidazolium ionic liquid mixture is developed in order to produce inexpensive solvents for biphasic hydrogenation of poly(acrylonitrile-butadiene) rubbers (NBR) catalyzed by RuHCl(CO)(PCy3)2.
Survive the construction jungle (1993)

Insists that like most industries, the construction industry has felt the pinch of the most recent recession and in all areas management is shifting towards cutbacks and retrenchment. Argues that this is the best time for managers in the industry to start recognising opportunities that will help give a company that extra advantage when the economy improves. Cites the example of Sheffield City Council′s decision to launch a programme for organizational development.
Adult Pediatric Patients (2001)

Increasingly, children with chronic pediatric conditions are living well into adulthood. Here's how to help your patients make the transition from pediatric to adult care.
Synthesis and antibacterial activity of the metabolites of 9-fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidyl)-5-methyl-1-oxo-1H,5H-benzo(i, j)quinolizine-2-carboxylic acid (OPC-7251). (1990)

The metabolites of 9-fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidyl)-5-methyl-1-oxo-1H,5H- benzo[i,j]quinolizine-2-carboxylic acid (OPC-7251) (1), which has a potent antibacterial activity against gram-positive bacteria, characteristically Propionibacterium acnes, were synthesized to confirm their structures and to examine their antibacterial activity. The structures of three major metabolites (2, 3a and 4) were identified by means of comparison with the synthetic compounds. The antibacterial activity of the metabolites (2, 3a and 4) was found to be lower than that of 1.
Control of astigmatism in proton isolated stripe aigaas double heterostructure lasers (1986)

Astigmatism was measured for proton isolated stripe geometry AIGaAs thin-active-layer (TAL) lasers, for which the proton implant depth was varied. Astigmatism was found to be smallest for deep implants close to the active layer. A semi-empirical model is presented which relates astigmatism to mode width, injected carrier distribution (gain width or spontaneous emission width), lateral dielectric constant variation across the laser stripe (determined from side lobe angle in far field) and active layer thickness. Comparison of experimental results with calculations are sufficiently precise to aid in practical laser design.
MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis (2016)

Lymphangiogensis is involved in various pathological conditions, such as arthritis and cancer metastasis. Although many factors have been identified to stimulate lymphatic vessel growth, little is known about lymphangiogenesis inhibitors. Here we report that membrane type 1-matrix metalloproteinase (MT1-MMP) is an endogenous suppressor of lymphatic vessel growth. MT1-MMP-deficient mice exhibit spontaneous corneal lymphangiogenesis without concomitant changes in angiogenesis. Mice lacking MT1-MMP in either lymphatic endothelial cells or macrophages recapitulate corneal lymphangiogenic phenotypes observed in Mmp14(-/-) mice, suggesting that the spontaneous lymphangiogenesis is both lymphatic endothelial cells autonomous and macrophage associated. Mechanistically, MT1-MMP directly cleaves LYVE-1 on lymphatic endothelial cells to inhibit LYVE-1-mediated lymphangiogenic responses. In addition, MT1-MMP-mediated PI3Kδ signalling restrains the production of VEGF-C from prolymphangiogenic macrophages through repressing the activation of NF-κB signalling. Thus, we identify MT1-MMP as an endogenous inhibitor of physiological lymphangiogenesis.
SYSTEMIC NON-HODGKIN’S LYMPHOMA WITH OPTIC NERVE INFILTRATION IN A PATIENT WITH AIDS (2002)

This case demonstrates that infiltrative optic neuropathy may occur as the sole ocular manifestation of disease recurrence in a patient with systemic non-Hodgkin's lymphoma otherwise thought to be in clinical remission.
Partial purification and some properties of homoserine O-acetyltransferase of a methionine auxotroph of Saccharomyces cerevisiae (1987)

A wild-type strain and six methionine auxotrophs of Saccharomyces cerevisiae were cultured in a synthetic medium supplemented with 0.1 mM L-cysteine or L-methionine and analyzed for the synthesis of homoserine O-acetyltransferase (EC 2.3.1.31). Among them, four mutant strains exhibited enzyme activity in cell extracts. Methionine added to the synthetic medium at concentrations higher than 0.1 mM repressed enzyme synthesis in two of these strains. The enzyme was partially purified (3,500-fold) from an extract of a mutant strain through ammonium sulfate fractionation and chromatography on columns of DEAE-cellulose, Phenyl-Sepharose C1-4B, and Sephadex G-150. The enzyme exhibited optimal pH at 7.5 for activity and at 7.8 for stability. The reaction product was ascertained to be O-acetyl-L-homoserine by confirming that it produced L-homocysteine in an O-acetyl-L-homoserine sulfhydrylase reaction. The Km for L-homoserine was 1.0 mM, and for acetyl coenzyme A it was 0.027 mM. The molecular weight of the enzyme was estimated to be approximately 104,000 by Sephadex G-150 column chromatography and 101,000 by sucrose density gradient centrifugation. The isoelectric point was at pH 4.0. Of the hydroxy amino acids examined, the enzyme showed reactivity only to L-homoserine. Succinyl coenzyme A was not an acyl donor. In the absence of L-homoserine, acetyl coenzyme A was deacylated by the enzyme, with a Km of 0.012 mM. S-Adenosylmethionine and S-adenosylhomocysteine slightly inhibited the enzyme, but methionine had no effect.
J. C. Frommann (1857)

Journal Article J. C. Frommann Get access R. C. R. C. 1Cork Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s2-IV, Issue 79, 4 July 1857, Page 8, https://doi.org/10.1093/nq/s2-IV.79.8c Published: 04 July 1857
Regulation of CD4 T Cell Differentiation by CD44 (2008)

CD4 T cells can polarize to Th1, Th2 and newly emerged Th17 lineage. The involvement of cytokines and signaling pathways that trigger such polarization are largely known. However, cells and molecules regulating the differentiation are not identified, especially in consideration of primary versus secondary immune response. In the current study, we found that CD44 plays an important role in CD4 T cell differentiation. By comparing immune responses to SRBC and OVA in CD44‐deficient and CD44‐sufficient mice, we observed that CD44 deficiency triggers a decreased Th1 immunity and an increased Th2 response. The decreased Th1 response correlated with a decrease in many of the components including macrophage migration, delayed‐type hypersensitivity, IgG2a production, and SRBC‐induced hemagglutination. However, there was an increase in IgG1 production. CD44‐deficient mice also had a down‐regulated expression of T‐bet and Th1‐cytokines but an enhanced expression of GATA3 and Th2‐cytokines. The skewed immunity occurred in either primary or secondary immune response. The decreased serum IL‐17 production, splenic Th17 population and dendritic cell functions in CD44‐deficient mice may contribute towards a shift from Th1 to Th2 cell polarization. (This work was supported in part by NIH grants: AI053703, ES09098, AI058300, DA016545, HL058641 and P01AT003961).
A Case of Hepatic Cirrhosis and Obstructive Icterus in the Canine (1968)

On September 1, 1967 an eight year old spayed female Dachshund was presented to the Iowa State university Veterinary Clinic with a history of progressively losing condition. The owners remarked that she had been in good health and had just begun to lose weight recently. The also stated that her appetite was poor and that she had frequent periods of constipation characterized by scanty amounts of clay-colored feces.
EVALUATION OF ROOFTOP GREENING AS A METHOD OF HEAT-ISLAND REDUCTION BASED ON ACTUAL MEASUREMENT (2006)

Heat-island phenomenon has become obvious in urban area of recent years. Rooftop greening become a specific and effective measures of alleviating this problem. Maintenance easily vegetations such as sedam are applied to rooftop greening products initially, but recently there are many products using turf because it is important to evaporate from vegetations for reducing sensible heat flux of rooftop. Many previous studies mainly dealt with vegetations on the ground, but it's conceivable that rooftop greening products possess different characteristics from natural ones because of specific soil, watering system and so on. This paper presents heat and water budget characteristics of rooftop greening products based on long term actual measurement, reduction effect of heat-island by provisional estimation.
Thermal Barrier Coatings for the 21st Century (1999)

Yttria stabilized zirconia (YSZ) thermal barrier coatings (TBCs) fabricated via electron beam physical vapor deposition (EBPVD) provide some unique properties for aerofoil applications. Such coatings are usually deposited on diffusion aluminide or MCrAlY bond coats on superalloy substrates. During deposition of the YSZ-TBC on the bond coat, a thermally grown oxide (TGO) consisting primarily of -Al2O3 is formed between the TBC and bond coat. The lives of these TBCs in oxidizing environments is determined by the interplay of the stored elastic energy driving spallation versus the interfacial toughness of the TGO/bond coat interface since failure of the TBC system often occurs at this interface. The microstructures of EBPVD-TBCs in the as-processed and exposed conditions have been documented using a variety of techniques to determine and describe the failure mechanisms. It is shown that the failure mechanisms for TBC’s are dependent on the bond coat fabrication procedure and the exposure environment. Finally, possible schemes for improving TBC systems are outlined.
Mahalanobis Distance of Reservoir States for Online Time-Series Anomaly Detection (2023)

&lt;p&gt;Automated anomaly detection in time-series data has important applications in modern society. In practical settings, sequence patterns must often be evaluated in real-time under limited computational resources and scarce training data, presenting significant challenges. Reservoir computing models can help reconcile the trade-off between computational expense and precision in such situations. We propose the Mahalanobis distance of reservoir states (MD-RS) method, as an alternative to standard reservoir-based methods that rely on prediction error. MD-RS can effectively highlight anomalies because it measures the deviation from the subspace that minimally encompasses reservoir responses to normal inputs. Our semi-supervised MD-RS method only requires training data labeled as normal, making it suitable for practical scenarios under limited training data. Both the training and inference can be performed online with reduced computational cost, enabling real-time anomaly detection. We apply the MD-RS method to a benchmark dataset with a short training phase from the UCR time series anomaly archive and demonstrate its superiority in terms of accuracy, reliability, and robustness over prediction error-based methods when employing the same reservoir. Additionally, we propose the response dimension increase (RDI) index for initial hyperparameter tuning, which measures the increase in the effective dimension of the reservoir trajectories. These results position our method as a leading choice for applications requiring rapid and accurate anomaly detection.&lt;/p&gt;
Ranganathan and The Annals (1992)

Contribution de Ranganathan a la bibliotheconomie et a la documentation a travers des donnees chiffrees sur le nombre de ses articles publies dans les annals et sur leurs champs disciplinaires dont celui, predominant, de la classification
Modulation of the inactivation of voltage-dependent potassium channels by cAMP (1995)

Modulation of voltage-dependent potassium currents can alter the shape and timing of action potentials, thereby altering neurotransmitter release. To examine the effect of a cAMP analog on potassium currents in metabolically intact cells, perforated-patch and cell-attached patch recordings were carried out using the GH4C1 pituitary cell line. A major component of voltage-dependent potassium current in these cells inactivates slowly, with a time constant of several seconds. Application of dibutyryl cAMP decreased this current at voltages positive to -10 mV and increased the rate of inactivation by approximately twofold. Single channel recordings revealed two channel types whose voltage dependence and kinetics of inactivation match those of the macroscopic current. One of these, the smaller conductance (7.5 pS) channel, was sensitive to the cAMP analog, which decreased the latency of the channel to enter a long-lasting inactivated state. Ensemble averages of the activity of this channel showed that, consistent with its effect on the macroscopic current, dibutyryl cAMP increased its rate of inactivation. Somatostatin, an agent that is known to activate a serine/threonine phosphatase in these cells, completely reversed the effect of dibutyryl cAMP on the channel, while the cyclic GMP analog, dibutyryl cyclic GMP was without effect. In contrast, the rate of inactivation of the larger conductance (approximately 19 pS) channel was not accelerated by dibutyryl cAMP. These studies indicate that different channel subtypes expressed in a single cell respond differently to elevations of cAMP, and suggest that the overall response of potassium currents to second messengers may be determined by the ratio of different channel subtypes.
Supplementary Figure from ARRY-382 in Combination with Pembrolizumab in Patients with Advanced Solid Tumors: Results from a Phase 1b/2 Study (2023)

Supplementary Figure from ARRY-382 in Combination with Pembrolizumab in Patients with Advanced Solid Tumors: Results from a Phase 1b/2 Study
An Information Retrieval Approach to Short Text Conversation (2014)

Human computer conversation is regarded as one of the most difficult problems in artificial intelligence. In this paper, we address one of its key sub-problems, referred to as short text conversation, in which given a message from human, the computer returns a reasonable response to the message. We leverage the vast amount of short conversation data available on social media to study the issue. We propose formalizing short text conversation as a search problem at the first step, and employing state-of-the-art information retrieval (IR) techniques to carry out the task. We investigate the significance as well as the limitation of the IR approach. Our experiments demonstrate that the retrieval-based model can make the system behave rather "intelligently", when combined with a huge repository of conversation data from social media.