gebhart/patrepeval huggingface dataset:
O-GlcNAcylation Suppresses the Ion Current IClswell by Preventing the Binding of the Protein ICln to α-Integrin (2020)

<i>O</i>-GlcNAcylation is a post-translational modification of proteins that controls a variety of cellular processes, is chronically elevated in diabetes mellitus, and may contribute to the progression of diabetic complications, including diabetic nephropathy. Our previous work showed that increases in the <i>O</i>-GlcNAcylation of cellular proteins impair the homeostatic reaction of the regulatory volume decrease (RVD) after cell swelling by an unknown mechanism. The activation of the swelling-induced chloride current IClswell is a key step in RVD, and ICln, a ubiquitous protein involved in the activation of IClswell, is <i>O</i>-GlcNAcylated. Here, we show that experimentally increased <i>O</i>-GlcNAcylation of cellular proteins inhibited the endogenous as well as the ICln-induced IClswell current and prevented RVD in a human renal cell line, while decreases in <i>O</i>-GlcNAcylation augmented the current magnitude. In parallel, increases or decreases in <i>O</i>-GlcNAcylation, respectively, weakened or stabilized the binding of ICln to the intracellular domain of α-integrin, a process that is essential for the activation of IClswell. Mutation of the putative YinOYang site at Ser67 rendered the ICln-induced IClswell current unresponsive to <i>O</i>-GlcNAc variations, and the ICln interaction with α-integrin insensitive to <i>O</i>-GlcNAcylation. In addition, exposure of cells to a hypotonic solution reduced the <i>O</i>-GlcNAcylation of cellular proteins. Together, these findings show that <i>O</i>-GlcNAcylation affects RVD by influencing IClswell and further indicate that hypotonicity may activate IClswell by reducing the <i>O</i>-GlcNAcylation of ICln at Ser67, therefore permitting its binding to α-integrin. We propose that disturbances in the regulation of cellular volume may contribute to disease in settings of chronically elevated <i>O</i>-GlcNAcylation, including diabetic nephropathy.
Bilateral cerebellar cysts and cerebral white matter lesions with cortical dysgenesis: Expanding the phenotype of LAMB1 gene mutations (2018)

LAMB1 gene analysis should be considered for intellectually disabled patients with cerebellar cysts, white matter signal change, and cortical malformation. Muscular involvement is absent, in contrast to the α-dystroglycanopathy types of congenital muscular dystrophies.
Development of a Generalized Control Strategy for Thermal Energy Storage in Residential Buildings (2018)

In recent years, variable electricity pricing has become available to residential consumers to incentivize demand reductions during traditional midday peak hours. This is especially important in hot climates where air-conditioning (A/C) use is the primary cause for peak electricity demand. Thermal storage allows consumers to store “cooling” when demand is low and minimize operation of the A/C during peak periods. This paper considers a packaged A/C integrated with thermal energy storage using ice for residential cooling applications. The focus of the paper is the development and validation of a generalized control strategy that can be used for available residential utility rate structures that include different combinations of time-of-use energy and demand charges. The generalized control strategy is based on a unique combination of different heuristic strategies for charging and discharging of storage that are typically applied to commercial-scale A/C systems with integrated thermal energy storage. In order to evaluate overall performance, a model of the proposed system is developed and used to calculate cooling season operating costs for different geographic locations and utility rates. The performance of the generalized strategy is evaluated in comparison to the most commonly employed control strategy for commercial ice storage systems, called chiller priority control. A range of unit capacities, storage sizes, geographic locations, and residential utility rates are considered. The resulting decrease in operating cost with the generalized control strategy, when compared to chiller priority control, was as much as 50% based on the utility rates considered in this paper.
Molecular cytogenetic delineation of the breakpoint at 18q21.1 in low‐grade B‐cell lymphoma of mucosa‐associated lymphoid tissue (1999)

Extranodal malignant non-Hodgkin lymphoma of mucosa-associated lymphoid tissue type (MALT lymphoma) represents a subtype of B-cell lymphoid malignancies with distinct clinicopathological features and is often associated with a favorable prognosis. Recent cytogenetic studies have revealed that t(11;18)(q21;q21) is a characteristic chromosomal aberration in low-grade B-cell MALT-type lymphoma. In the present study, we employed florescence in situ hybridization analysis using contiguous YAC clones mapped to the 18q21.1 region to identify a YAC clone, y789F3, encompassing the breakpoint of t(11;18)(q21;q21) in a MALT lymphoma. P1 artificial chromosome (PAC) contigs constructed on this YAC clone were used to analyze the breakpoint region. PAC clone 264m4 was observed on normal chromosome 18 and on der(18), and PAC clone 879n10 on normal chromosome 18 and on der(11), confirming that the breakpoint is located between these two PAC clones. We also found that a region of approximately 500 kb between the two PAC clones was deleted. These results indicate that the locus between PAC clones 264m4 and 879n10 at 18q21.1 involved in t(11;18) translocation or associated deletion plays an important role in the development of MALT lymphoma. Genes Chromosomes Cancer 24:315–321, 1999. © 1999 Wiley-Liss, Inc.
OS0822 Prediction of low cycle fatigue life of elbow by revised universal slope method (2014)

Low-cycle fatigue tests and finite element analysis were conducted using 100A elbow pipes made of STPT410 carbon steel or SUS304 stainless steel with local wall thinning. Local wall thinning was machined on the inside of the elbows in order to simulate local wall thinning. The local wall thinning located in two different areas, called extrados and crown. The elbows were subjected to cyclic in-plane bending under displacement control with inner pressure of 9 MPa. The crack penetration and the crack direction were predicted accurately by finite element analysis in consideration of principal strain range and bi-axial stress factor. Fatigue lives could be predicted accurately by the revised universal slope method.
Crystals of phospholipid analogues as plausible material for molecular electronics. I: Synthesis and investigation of the structure and physical properties of two halogen hydride derivatives of isobutyl-2-aminoethyl phosphate—phosphatidylethanolamine analogues (1996)

Synthesis and investigation of the structure and electrophysical properties of two halogen hydride derivatives of isobutyl analogues of phosphatidylethanol amine (IPE), namely IPE-HCl and IPE-HBr, were performed to offer a new material for ‘molecular wires’ according to the model of molecular electronics developed earlier by Karasev et al. (Adv. Mater. Opt. Electron., 1994, 4, pp. 203–218). X-ray analysis showed that isostructural crystals of the synthesised compounds are monoclinic with the space symmetry group I2/a (C2/c). They have very similar lattice cell parameters, namely a = 21.892(8), b = 4.7747(2), c = 44.63(2) Å, β = 91.83(3)°, Z = 16 for IPE-HCl and a = 22.115(14), b = 4.808(3), c = 44.83(2) Å, β = 91,74(5)°, Z = 16 for IPE-HBr. It was found that the structure of IPE-HCl contains two symmetrically unrelated molecules of IPE. They form two bilayers within the elementary cell each of which includes three zones of hydrogen bonds. The central zone is formed by NH3 groups belonging to IPE and by chloride ions. The other two zones are quasi-one-dimensional systems of HO(SINGLE BOND)P(DOUBLE BOND)O groups generated by translationally related IPE molecules and can be considered as prospective ‘molecular wires’. These two zones are located symmetrically with respect to the central zone. Electrophysical parameters (contuctance γ and complex dielectric permittivity components ϵ′ and ϵ″) were determined for polycrystalline samples of IPE-HCl and IPE-HBr in the temperature range from −20 to 70°C. The permittivity ϵ′ was found to assume abnormally high values (about 106) at low frequency and to decrease monotonically with increasing temperature in the frequency range from 50 Hz to 10 MHz. Possible mechanisms of polarisation of the synthesised IPE derivatives are analysed. The conductance of the crystals was shown to have an activation character with the activation energy equal to 0.7–1.3 eV for IPE-HCl and 0.4–0.6 eV for IPE-HBr. A hopping mechanism was proposed to explain charge transfer along the systems of HO(SINGLE BOND)P(DOUBLE BOND)O groups involving Cl− and Br− ions.
Single Nigrostriatal Dopaminergic Neurons Form Widely Spread and Highly Dense Axonal Arborizations in the Neostriatum (2009)

The axonal arbors of single nigrostriatal dopaminergic neurons were visualized with a viral vector expressing membrane-targeted green fluorescent protein in rat brain. All eight reconstructed tyrosine hydroxylase-positive dopaminergic neurons possessed widely spread and highly dense axonal arborizations in the neostriatum. All of them emitted very little axon collateral arborization outside of the striatum except for tiny arborization in the external pallidum. The striatal axonal bush of each reconstructed dopaminergic neuron covered 0.45-5.7% (mean +/- SD = 2.7 +/- 1.5%) of the total volume of the neostriatum. Furthermore, all the dopaminergic neurons innervated both striosome and matrix compartments of the neostriatum, although each neuron's arborization tended to favor one of these compartments. Our findings demonstrate that individual dopaminergic neurons of the substantia nigra can broadcast a dopamine signal and exert strong influence over a large number of striatal neurons. This divergent signaling should be a key to the function of the nigrostriatal system in dopamine-based learning and suggests that neurodegeneration of individual nigral neurons can affect multiple neurons in the striatum. Thus, these results would also contribute to understanding the clinicopathology of Parkinson's disease and related syndromes.
A 1024-channel CMOS microelectrode-array system with 26'400 electrodes for recording and stimulation of electro-active cells in-vitro (2013)

We report on a CMOS microelectrode array system chip for recording and stimulation of electrogenic cell cultures and tissues, featuring a sensing area of 8.09 mm2, composed of 26'400 electrodes at 17.5 μm pitch. A user-configurable selection of the electrodes can be routed to 32 stimulation units and to 1024 recording channels with 2.4 μVrms input-referred noise and 10-bit 20-kS/s A/D conversion. The system offers a versatile platform with excellent signal characteristics for a wide range of electrophysiological recordings.
Increased Levels of Alternatively Spliced Interleukin 4 (IL-4δ2) Transcripts in Peripheral Blood Mononuclear Cells from Patients with Systemic Sclerosis (1999)

Recent in vitro studies have shown that interleukin 4 (IL-4) induces and gamma interferon (IFN-gamma) inhibits collagen production. To define the TH1(IFN-gamma) and TH2(IL-4) cytokine profiles in systemic sclerosis (Sscl), a disease characterized by widespread fibrosis, we investigated IL-4 and IFN-gamma transcripts in peripheral blood mononuclear cells and plasma protein levels in 13 patients with Sscl. Two previously identified IL-4 transcripts, a full-length transcript and an alternatively spliced (truncated) transcript (designated IL-4delta2), were identified in patients and normal controls. Significantly increased levels of total IL-4 transcripts (full-length plus IL-4delta2 transcripts) were found in patients with Sscl in comparison to those found in healthy controls (P = 0.003), and this increase was primarily due to an increase in the level of the alternatively spliced IL-4delta2 form. The IL-4delta2/full-length-IL-4 transcript ratio was significantly increased in Sscl patients (P < 0.0001, versus healthy controls). Sequencing analysis revealed that the frequency of IL-4 clones carrying the IL-4delta2 transcript was also substantially increased in patients with Sscl. Plasma IL-4 protein levels were increased in Sscl patients compared to those in healthy controls (P = 0.001) and correlated with total IL-4 transcript levels. The up-regulation of the fibrogenic IL-4 (a TH2 cytokine) in Sscl suggests a pathogenic role for IL-4 in this disease.
No enhancement of sensory and motor blockade by ketamine added to ropivacaine interscalene brachial plexus blockade (2002)

This study suggests that 30 mg ketamine added to ropivacaine in the brachial plexus block does not improve the onset or duration of sensory block, but it does cause a relatively high incidence of adverse-effects. These two findings do not encourage the use of ketamine with local anesthetics for brachial plexus blockade.
ChemInform Abstract: Total Synthesis of the Anthelmintic Agent Hikizimycin. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Impact of SMT Connector Pads on High Speed Serial Links (2018)

Connectors are needed when high speed serial links pass through multiple printed circuit boards (PCBs) or cables. Surface mount (SMT) connectors play an important role in improving signal integrity as signal speeds continue to increase. Orientation of SMT connector lead frame when mounting on the PCB pad determines the direction of the signal breakout. Improper breakout of the signal due to the via location or otherwise can create an unintentional stub at the connector pad that can impact signal quality. In this paper, the impact of SMT connector pad on high speed serial link is discussed along with some examples. Proper breakout from the connector can result in short pad stubs. In cases where proper breakout is not possible, via-in-pad design is proposed as an approach to mitigate the risk for high speed designs.
UV-B radiation and ozone depletion : effects on humans, animals, plants, microorganisms, and materials (1993)

Energetics and kinetics of nuclear transformations interaction of radiation with matter external radiation protection dosimetry recommendations and standards measurement radioactive waste radon.
Theorical and numerical analysis of an all‐optical delta‐sigma modulator (2017)

ABSTRACT Delta‐sigma modulation is a powerful technique for optical signal processing due to its high bandwidth, noise immunity, and low cost. In this article, a theory for all‐optical delta‐sigma modulation is presented along with the calculation and design parameters for optical system implementation. An optical delta‐sigma modulator can be used in a microwave photonic link to encode the radio frequency signal into the duty cycle of the optical pulses. Simulation results are presented that confirm the theory and also the possibility of reaching a few GHz modulation rate in a chip‐level implementation. © 2017 Wiley Periodicals, Inc. Microwave Opt Technol Lett 59:1168–1173, 2017
Through-the-glass spectroscopic ellipsometry for analysis of CdTe thin-film solar cells in the superstrate configuration (2016)

The polycrystalline CdS/CdTe thin-film solar cell in the superstrate configuration has been studied by spectroscopic ellipsometry (SE) using glass side illumination whereby the reflection from the glass/film-stack interface is collected whereas that from the ambient/glass interface is rejected. The SE data analysis applies dielectric functions ( <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>ε</mml:mi></mml:math> ) for solar cell component materials obtained by variable-angle and in-situ SE. In the SE analysis of the complete cell, a step-wise procedure ranks the free parameters, including thicknesses and those defining the spectra in <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>ε</mml:mi></mml:math> , according to their ability to reduce the root-mean-square deviation between simulated and measured SE spectra, and the best-fit results compare well with electron microscopy. Combining all SE results, the solar cell quantum efficiency (QE) can be simulated without free parameters, and comparisons with QE measurements enable identification of losses. The capabilities have wide applications in photovoltaic module mapping and in-line monitoring.
A perforator from the ulnar artery and cutaneous nerve of the hypothenar area: An anatomical study for clinical application (2015)

The most consistent area for sensate flap elevation was the region around 5%-15% on the x-axis and 25%-50% on the y-axis. We expect that our data concerning perforator artery and cutaneous nerve branches in the hypothenar area of the hand will aid in establishing appropriate clinical usage of the hypothenar perforator flap. © 2014 Wiley Periodicals, Inc. Microsurgery 37:49-56, 2017.
Characterization of MR Imaging–Visible Perivascular Spaces in the White Matter of Healthy Adolescents at 3T (2020)

Despite a wide range of burden, perivascular spaces are present in all healthy adolescents. Perivascular space burden is higher in adolescent males than in females, regardless of age and pubertal status. In this population, perivascular spaces are highly symmetric. Although widely reported as a feature of the aging brain, awareness of the presence of perivascular spaces in a cohort of healthy adolescents provides the foundation for further research regarding the role of these structural variants in health and disease.
Convenient Auditory-Based Language and Executive Function Test for Patients With Amyotrophic Lateral Sclerosis: A Pilot Study (2022)

Our findings indicated that the CABLET could be useful in identifying ALSci quickly without adjusting for confounding factors. Further validation is required to evaluate it in larger groups and compare with ALS-specific cognitive screen.
EFFECTS OF DYNAMIC MISALIGNMENTS AND FEEDBACK PERFORMANCE ON LUMINOSITY STABILITY IN LINEAR COLLIDERS (2003)

The performance of high energy linear colliders depends critically on the stability with which they can maintain the collisions of nanometer-size beams. Ground motion and vibration, among other effects, will produce dynamic misalignments which can offset the beams at the collision point. A system of train-to-train and intra-train beam-beam feedbacks, possibly combined with additional beam-independent active systems, is planned to compensate for these effects. Extensive simulation studies of ground motion and luminosity stabilization have been performed as part of the work of the International Linear Collider Technical Review Committee [1]. This paper presents a comparison of the expected performance for TESLA, JLC/NLC and CLIC under various assumptions about feedbacks and the level of ground motion.
Glaucoma Patient Preferences for Video Education on Eye Drop Technique (2019)

Eye drop technique videos should be disseminated in the doctor's office and online. Health systems that integrate educational videos into their everyday practice may be able to use technique videos to improve patient technique at low cost and little time burden to the provider.
A no-loss covariance intersection algorithm for track-to-track fusion (2010)

Compared to the optimal track-to-track fusion (T2TF) algorithm under linear Gaussian assumption and the information matrix fusion, the major advantage of the covariance intersection (CI) method for the problem of T2TF is that it neither needs the crosscovariances between the local tracks, nor does it use local information increments which are required to be independent. This allows the CI method to be used in scenarios where the optimal T2TF and the information matrix fusion algorithms are difficult or impractical to implement. However, a significant drawback of the original CI algorithm is that it is too conservative and will yield unnecessary loss in its calculated fusion accuracy. Even worse, as shown in this paper, this loss increases with the number of local tracks for fusion. This greatly degrades the usefulness of the CI algorithm. In this paper, a new "sampling CI" algorithm is proposed, which is simple to implement and does not have the above problematic feature of the original CI. Simulation results from various scenarios demonstrate the effectiveness of the proposed algorithm.
Caesalminaxins A–L, Cassane Diterpenoids from the Seeds of Caesalpinia minax (2013)

Fourteen new cassane diterpenoids, caesalminaxins A-L (1-14), and three known compounds were isolated from the seeds of Caesalpinia minax. Among the new diterpenoids, compounds 3 and 4 possess a rare spiro C/D ring system. The C-16 epimeric mixture 1/2 has an unprecedented carbon skeleton, presumably derived from 3 by cleavage of the C-13-C-14 bond. Compound 5 is the first example of a cassane diterpenoid with a spiro A/B ring system. The structures of the compounds were elucidated on the basis of 1D and 2D NMR analysis, and the absolute configurations of 3, 4, 9, and 11 were determined by single-crystal X-ray crystallography. Biosynthesis pathways for 1/2, 3, and 5 are postulated. Compounds 4, 8, and the known bonducellpin D exhibited moderate activity against four tested human cancer cell lines, HepG-2, K562, HeLa, and Du145.
Virtual Screening of Molecular Databases Using a Support Vector Machine (2005)

The Support Vector Machine (SVM) is an algorithm that derives a model used for the classification of data into two categories and which has good generalization properties. This study applies the SVM algorithm to the problem of virtual screening for molecules with a desired activity. In contrast to typical applications of the SVM, we emphasize not classification but enrichment of actives by using a modified version of the standard SVM function to rank molecules. The method employs a simple and novel criterion for picking molecular descriptors and uses cross-validation to select SVM parameters. The resulting method is more effective at enriching for active compounds with novel chemistries than binary fingerprint-based methods such as binary kernel discrimination.
The effect of Aβ seeding is dependent on the presence of knock-in genes in the AppNL−G−F mice (2022)

Alzheimer's disease (AD) is characterized by the prion-like propagation of amyloid-β (Aβ). However, the role of Aβ in cognitive impairment is still unclear. To determine the causal role of Aβ in AD, we intracerebrally seeded the entorhinal cortex of a 2-month-old <i>App</i> <sup><i>NL</i>-<i>G</i>-<i>F</i></sup> mouse model with an Aβ peptide derived from patients who died from rapidly progressing AD. When the mice were 3 months of age or 1 month following seeding, spatial learning and memory were tested using the Morris water task. Immunohistochemical labeling showed seeding with the Aβ was found accelerate Aβ plaque deposition and microgliosis in the <i>App</i> <sup><i>NL</i>-<i>G</i>-<i>F</i></sup> mice, but this was dependent on the presence of the knocked-in genes. However, we found no correlation between pathology and spatial performance. The results of the present study show the seeding effects in the <i>App</i> <sup><i>NL</i>-<i>G</i>-<i>F</i></sup> knock-in model, and how these are dependent on the presence of a humanized <i>App</i> gene. But these pathological changes were not initially causal in memory impairment.
3-octave Supercontinuum Generation and Sub-2-cycle Self-compression of Mid-IR Filaments in Dielectrics (2014)

We demonstrate more than 3-octave supercontinuum for the first time from ZnS in the normal dispersion regime and self-compression of the mid-IR pulse to sub-2-cycle for the first time in CaF2 in the anomalous dispersion regime.
CHILD OWLET (2014)

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