gebhart/patrepeval huggingface dataset:
Optimal preparation techniques for human saphenous vein grafts. (1980)

Endothelial damage during preparation of saphenous vein grafts is an important cause of early and late graft failure. To determine optimal preparation techniques for human saphenous veins (SVs), we made a scanning electron microscopic comparison of the effects of handling techniques, immersion media, and distention pressures on human SV morphology. Segments of SVs from 30 patients were divided into seven groups of five veins each. The effects of both blood and saline solution immersion at 4 degrees and 28 degrees C, 100 and 300 mm Hg distention pressures, and trauma from surgical instrumentation were examined. All groups of veins were fixed by perfusion with glutaraldehyde at 100 mm Hg to simulate arterial pressure and were examined with a scanning electron microscope. SVs immersed in warm saline solution showed massive endothelial cell loss, whereas SVs immersed in warm blood showed only moderate endothelial damage. Cold blood and saline immersion fully preserved endothelium; however, cold saline immersion produced mural edema. Distention to 300 mm Hg with saline solution produced severe endothelial damage and edema, an effect lessened by blood distention. Vascular clamping destroyed endothelium and fractured the intima and media. Marked luminal stenoses were caused by four of seven side branch ties that appeared normal externally. We conclude that human SVs are preserved best by a "no touch" harvesting technique in which manipulation is minimized, side branch ties are placed away from the SV wall, veins are immersed in cold blood, and distention above 100 mm Hg is avoided.
Efficacy of fimasartan/hydrochlorothiazide combination in hypertensive patients inadequately controlled by fimasartan monotherapy (2015)

The combination treatment of fimasartan and HCTZ achieved better BP control than fimasartan monotherapy, and had comparable safety and tolerance to fimasartan monotherapy.
Somatostatin and prosomatostatin in the retina of the rat: An immunohistochemical, in-situ hybridization, and chromatographic study (1990)

Specific antisera, raised in rabbits, against somatostatin 1-14, somatostatin 1-28, the fragment 1-12 of somatostatin 1-28, and prosomatostatin 20-36 were used for immunohistochemistry and gel filtration of the rat retina. With all antisera, immunoreactive perikarya could be located in the inner nuclear and ganglion cell layers. In the inner nuclear layer, amacrine cells with processes extending predominantly into the first sublayer of the inner plexiform layer were observed. Some processes extended also to the ganglion cell layer. In addition, somatostatin-immunoreactive interplexiform cells were present in the inner nuclear layer. In the ganglion cell layer, perikarya were found located in the midperiphery and in the far periphery of the retina. The neurons located in the midperiphery of the retina possessed a round perikaryon from which processes could be followed going into the inner plexiform layer, where they dichotomized in the third and first sublayers. The perikarya in the far periphery of the retina near the ora serrata exhibited an ovoid-shaped cell body from which processes extended horizontally in a bipolar manner in the layer itself. By use of an [35S]-labeled antisense oligonucleotide probe, in situ hybridization of the rat retina showed the presence of perikarya in the inner nuclear layer and ganglion cell layer containing mRNA encoding for prosomatostatin. Gel filtration of the retinal extracts followed by radioimmunoassay showed the presence of somatostatin 1-14, the fragment 1-12 of somatostatin 1-28, and prosomatostatin 1-64. However, somatostatin 1-28 was not detected. The results obtained in this study verify the presence of somatostatin 1-14 in the rat retina located in perikarya and processes in the inner nuclear and ganglion cell layers. The positive in-situ hybridization signals show that the intraneuronal somatostatin immunoreactivity is due to synthesis of the peptide and not uptake in the neurons. The presence of the somatostatin propeptide and fragments of this propeptide, in both intraretinal perikarya and fibers, indicate a posttranslational modification of this neuropeptide in the perikarya and the processes as well.
The Influence of the Degradation of Tetracycline by Free Radicals from Riboflavin-5′-Phosphate Photolysis on Microbial Viability (2019)

Tetracycline (TC) is a broad-spectrum antibiotic compound. Wastewater with TC may have an adverse effect on ecosystems. Riboflavin-5'-phosphate (FMN or flavin mononucleotide) is a non-toxic product of the phosphorylation of vitamin B<sub>2</sub> and is required for the proper functioning of the humans. FMN is sensitized to ultraviolet (UV) and blue light radiation, as evidenced by the generation of reactive oxygen species (ROS). This study inspects feasible applications of blue light on FMN so as to develop a valid way of degrading TC by FMN photolysis. We used the increased rate of bacterial survival as a practical indicator of antibiotic degradation. TC in the presence of FMN solution decomposed completely after 20 W/m<sup>2</sup> of blue light irradiation (TCF treatment), and the degradation of TC (D-TCF) occurred after the photolytic process. After TCF treatment, colony-forming units (CFUs) of <i>Escherichia coli</i> (<i>E. coli)</i> were determined for the D-TCF solution. The CFU of <i>E. coli</i> preservation was 93.2% of the D-TCF solution (50 μg/mL of TC in the presence of 114 μg/mL of FMN solution treated with 20 W/m<sup>2</sup> of blue light irradiation at 25 °C for 1 h) cultivation. The mass spectrum of D-TCF showed diagnostic ion signals at m/z 431.0 and 414.0 Da. The molecular formula of D-TCF was C<sub>21</sub>H<sub>22</sub>N<sub>2</sub>O<sub>8</sub>, and the exact mass was 430.44 g/mol. TC degradation by FMN photolysis can significantly decrease the antimicrobial ability of TC. The results expressed here regarding the influence of FMN photolysis on TC degradation offer an environmentally sound wastewater treatment method.
Supplementary Movie S1 from Breast Cancer Targeting through Inhibition of the Endoplasmic Reticulum-Based Apoptosis Regulator Nrh/BCL2L10 (2023)

&lt;p&gt;Time-lapse imaging of dTAT-NDP action on CAL-51 breast cancer cell line&lt;/p&gt;
Density dependence of the saturated velocity in graphene (2016)

The saturated velocity of a semiconductor is an important measure in bench-marking performance for either logic or microwave applications. Graphene has been of interest for such applications due to its apparently high value of the saturated velocity. Recent experiments have suggested that this value is very density dependent and can even exceed the band limiting Fermi velocity. Some of these measurements have also suggested that the scattering is dominated by the low energy surface polar mode of the SiO2 substrate. Here, we show that the saturated velocity of graphene on SiO2 is relatively independent of the density and that the scattering is dominated by the high energy surface polar mode of the substrate.
Functional food in athletes (2002)

Beneath a beneficial effect, physical exercise means stress to the organism. To an exhaustion of antioxidative capacity with the possible consequences of cell damage, lipid oxidation, or inflammatory responses, there is a suppressing effect of strenuous exercise on the immune system. A simple method to counteract all these side effects of physical activity without having adverse events itself is desirable. Probiotics (i.e., strains of Lactobacillus and Bifidobacterium ) combine some of the features needed. Immune enhancement and reinforcement of host defense by modifying unspecific and humoral immunocompetence has been documented. A basic approach has been made to an alternative: modifying intestinal flora by feeding the favorable strains with prebiotics, as oligofructose or inulin. Prebiotics do even more than only promote bifidobacterial and lactobacillar growth, however, and several other intestinal bacteria are clearly involved in their metabolism. Yet the data from controlled studies in prevention of specific diseases are not validated in the same manner as for probiotics. In addition, phytochemicals have additional effects completing possibilities of pre‐ and probiotics. The antioxidant potential often exceeds that of comparable amounts of vitamins C and E. Diet should contain enough fresh fruits and vegetables to cover recommendations of daily intake, as the health‐promoting effect has been well‐documented in epidemiological studies. Until now, because the general health‐promoting effect of pre‐ and probiotics among healthy, physically active people has not been clarified, these compounds may be indicated in select cases.
Cell cycling status of human cord blood CD34+ cells during ex vivo expansion is related to the level of very late antigen expression (2001)

Very late antigen-4 (VLA-4), which binds to the extracellular matrix protein fibronectin, is an integrin molecule known to be modulated during mobilization of CD34+ cells, and to be involved in signaling the mobilization stimuli. On the hypothesis that cell cycling status might be different depending on the level of VLA-4 expression, we investigated the DNA contents of human cord blood CD34+ cells during ex vivo expansion by recombinant human thrombopoietin and flt3-ligand with simultaneous measurement of surface VLA-4 at the 1st and 4th week. During this ex vivo expansion, expression of VLA-4 increased and almost all cells became VLA-4+ until the 4th day of culture. Expression of VLA-4 was maintained in the major population of the cultured cells until the 4th week. The cells in S/G2/M phase were greater in number in VLA-4 high fraction than in VLA-4 low fraction (n=4, p<.001). Furthermore, the fraction of cells in S/G2/M phase increased as the expression of VLA-4 became higher. These results suggest that cord blood CD34+ cells expressing high levels of VLA-4 have more proliferative activities.
Antibody Synthesis in Xenopus Oocytes with Messenger Ribonucleic Acid from Immunized Rats (1976)

Conference Article| August 01 1976 Antibody Synthesis in Xenopus Oocytes with Messenger Ribonucleic Acid from Immunized Rats NICHOLAS J. DEACON; NICHOLAS J. DEACON 1Department of Biochemistry, Queen Elizabeth College, London W8 7 AH, U.K. Search for other works by this author on: This Site PubMed Google Scholar ALAN EBRINGER ALAN EBRINGER 2Department of Biochemistry, Queen Elizabeth College, London W8 7 AH, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1976) 4 (4): 818–820. https://doi.org/10.1042/bst0040818 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation NICHOLAS J. DEACON, ALAN EBRINGER; Antibody Synthesis in Xenopus Oocytes with Messenger Ribonucleic Acid from Immunized Rats. Biochem Soc Trans 1 August 1976; 4 (4): 818–820. doi: https://doi.org/10.1042/bst0040818 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1976 Biochemical Society1976 Article PDF first page preview Close Modal You do not currently have access to this content.
On the incidence of wise infrared excess among solar analog, twin, and sibling stars (2020)

This study presents a search for infrared (IR) excess in the 3.4, 4.6, 12, and 22 μm bands in a sample of 216 targets, composed of solar sibling, twin, and analog stars observed by the Wide-field Infrared Survey Explorer (WISE) mission. In general, an IR excess suggests the existence of warm dust around a star. We detected 12 μm and/or 22 μm excesses at the 3σ level of confidence in five solar analog stars, corresponding to a frequency of 4.1% of the entire sample of solar analogs analyzed, and in one out of 29 solar sibling candidates, confirming previous studies. The estimation of the dust properties shows that the sources with IR excesses possess circumstellar material with temperatures that, within the uncertainties, are similar to that of the material found in the asteroid belt in our solar system. No photospheric flux excess was identified at the W1 (3.4 μm) and W2 (4.6 μm) WISE bands, indicating that, in the majority of stars of the present sample, no detectable dust is generated. Interestingly, among the 60 solar twin stars analyzed in this work, no WISE photospheric flux excess was detected. However, a null-detection excess does not necessarily indicate the absence of dust around a star because different causes, including dynamic processes and instrument limitations, can mask its presence.
3D Printing: Additive Manufacturing and Performance of Architectured Cement‐Based Materials (Adv. Mater. 43/2018) (2018)

3D-printed architectured cement-based materials exhibit improved mechanical properties compared to their cast counterparts. The presence of heterogeneous interfaces, combined with engineered architecture, promotes development of unique damage mechanisms, such as interfacial cracking and crack twisting, which lead to damage delocalization. This delocalization can be energetically favorable, thus resulting in more efficient energy dissipation, promotion of toughening and increase in damage tolerance, all without sacrificing the strength, as described by Pablo D. Zavattieri and co-workers in article number 1802123.
6.2.1 THE IMPACT OF SYSTEMS ENGINEERING ON QUALITY AND SCHEDULE *EMPIRICAL EVIDENCE* (1995)

Abstract Most Systems Engineering (SE) organizations have little need to prove their worth. SE disciplines are required to fulfill contractual line items. The worth of SE disciplines was long since proven. But not all companies and organizations are this lucky. In fact, a large company known for its strength in SE may have organizations that don't understand or practice SE disciplines. In these organizations, it can be difficult to “sell” Systems Engineering. This paper defines Systems Engineering and presents empirical evidence of its worth. Three similar projects were run in parallel. Each had varying degrees of SE disciplines implemented ‐from nearly none to high. The two projects using SE were delivered more than twice as fast. The project using the highest level of SE was delivered nearly three times faster and had the highest quality . While conclusions concerning what caused an outcome in any complex project are subjective, this paper compares the projects in detail so that conclusions can be drawn as to what caused cycle time and quality differences.
A Carboxyl-terminal Sequence in the Lutropin β Subunit Contributes to the Sorting of Lutropin to the Regulated Pathway (2008)

Although synthesized in the same pituitary gonadotropes, the secretion profiles of lutropin (LH) and follitropin (FSH) differ. LH is secreted through a regulated pathway and associated with a bolus release at mid-estrous cycle. In contrast, the majority of FSH is secreted constitutively with an incremental increase until ovulation. Both share an identicalalpha subunit, and thus thebeta subunit contains determinants for sorting into the regulated pathway. Previously, we demonstrated that a hydrophobic carboxyl-terminal heptapeptide of the LHbeta subunit (Leu-Ser-Gly-Leu-Leu-Phe-Leu), not found in the FSHbeta subunit, influences the intracellular behavior of the LH dimer. To test the hypothesis that the peptide contributes to differential sorting, we monitored the fates of LH and LHDeltaT (LHbeta subunit lacking the carboxyl-terminal seven amino acids) dimers in the rat somatotrope-derived GH(3) cell line in which both the regulated and constitutive secretory pathways operate. Pulse-chase labeling demonstrated that the LHDeltaT dimer was diverted to the constitutive pathway, resulting in a significant decrease in the corresponding intracellular pool. Forskolin stimulated LH dimer release 3-fold, which was accompanied by a parallel decrease of intracellular LH; only marginal forskolin stimulation of LHDeltaT was seen. Immunofluorescence after cycloheximide treatment demonstrated decreased retention of LHDeltaT compared with LH, consistent with increased constitutive secretion of LHDeltaT. We also demonstrated that fusing the heptapeptide to the carboxyl terminus of the FSHbeta subunit resulted in an increased regulated secretion of this FSH analog compared with wild-type FSH. These data are the first to identify a novel structural determinant responsible for the sorting of a member of the glycoprotein hormone family into the regulated secretory pathway.
CuCeOx/CuO Catalyst Derived from the Layered Double Hydroxide Precursor: Catalytic Performance in NO Reduction with CO in the Presence of Water and Oxygen (2023)

Valencies of metal species and lattice defects, such as oxygen vacancies, play a pivotal role in metal oxide-catalyzed reactions. Herein, we report a promising synthetic strategy for preparing CuO-supported CuCeO<sub><i>x</i></sub> catalysts (CuCeO<sub><i>x</i></sub>/CuO) by calcination of a hydrotalcite precursor [Cu<sub>6</sub>Ce<sub>2</sub>(OH)<sub>16</sub>]CO<sub>3</sub>·<i>n</i>H<sub>2</sub>O. The structural and chemical properties of catalysts were characterized by XRD, ICP-AES, TEM, TPR, NH<sub>3</sub>-TPD, XPS, Raman spectroscopy, and N<sub>2</sub> adsorption, which revealed that the thermal pretreatment in an oxidative atmosphere caused segregation and reconstitution processes of the precursor, resulting in a mesoporous catalyst consisting of well-dispersed CuO-supported CuCeO<sub><i>x</i></sub> clusters of 1.8-3.2 nm in size with a high population of oxygen vacancies. The as-prepared catalyst shows excellent catalytic performance in the reduction of NO by CO in the absence as well as in the presence of water and oxygen. This behavior is attributed to its high oxygen defect concentration facilitating the interplay of the redox equilibria between Cu<sup>2+</sup> and reduced copper species (Cu<sup>+</sup>/Cu<sup>0</sup>) and (Ce<sup>4+</sup>/Ce<sup>3+</sup>). The high surface population of oxygen vacancies and in situ-generated metallic copper species have been evidenced by Raman spectroscopy and X-ray photoelectron spectroscopy. The layered double hydroxide-derived CuCeO<sub><i>x</i></sub>/CuO also showed good water tolerance and long-term stability. In situ infrared spectroscopy investigations indicated that adsorbed hyponitrite species are the main reaction intermediates of the NO conversion as also corroborated by theoretical simulations.
Weakly Supervised Few-shot Object Segmentation using Co-Attention with\n Visual and Semantic Embeddings (2020)

Significant progress has been made recently in developing few-shot object\nsegmentation methods. Learning is shown to be successful in few-shot\nsegmentation settings, using pixel-level, scribbles and bounding box\nsupervision. This paper takes another approach, i.e., only requiring\nimage-level label for few-shot object segmentation. We propose a novel\nmulti-modal interaction module for few-shot object segmentation that utilizes a\nco-attention mechanism using both visual and word embedding. Our model using\nimage-level labels achieves 4.8% improvement over previously proposed\nimage-level few-shot object segmentation. It also outperforms state-of-the-art\nmethods that use weak bounding box supervision on PASCAL-5i. Our results show\nthat few-shot segmentation benefits from utilizing word embeddings, and that we\nare able to perform few-shot segmentation using stacked joint visual semantic\nprocessing with weak image-level labels. We further propose a novel setup,\nTemporal Object Segmentation for Few-shot Learning (TOSFL) for videos. TOSFL\ncan be used on a variety of public video data such as Youtube-VOS, as\ndemonstrated in both instance-level and category-level TOSFL experiments.\n
Asymmetric Inhibition of Ulk2 Causes Left-Right Differences in Habenular Neuropil Formation (2011)

Studies of the zebrafish epithalamus have provided recent insights into the development of left-right brain asymmetry, which is crucial to normal human brain function. The habenular nuclei of zebrafish are robustly asymmetric, with dense elaboration of neuropil only in the left lateral subnucleus. Because this feature is tightly correlated with asymmetric expression of K(+) channel tetramerization domain-containing proteins 12.1 and 12.2 (Kctd12.1/12.2), we screened for Kctd12.1-interacting proteins to identify molecular mechanisms leading to neuropil asymmetry, and uncovered a novel interaction between Kctd12.1 and Unc-51-like kinase 2 (Ulk2). We show here that knockdown of Ulk2 or overexpression of Kctd12 proteins reduces asymmetric neuropil elaboration. Conversely, overexpression of Ulk2 or mutation of kctd12 genes causes excess neuropil elaboration. We conclude that Ulk2 activity promotes neuropil elaboration while Kctd12 proteins limit Ulk2 activity asymmetrically. This work describes a regulatory mechanism for neuronal process extension that may be conserved in other developmental contexts in addition to the epithalamus.
Intramolecular Radical Reactions. Decomposition of o-Methyl-, o-Benzyl-, and o-Phenylbenzoyl Peroxide (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIntramolecular Radical Reactions. Decomposition of o-Methyl-, o-Benzyl-, and o-Phenylbenzoyl PeroxideFREDERICK D. GREENE, GILMAN R. VAN NORMAN, JAMES C. CANTRILL, and RICHARD D. GILLIOMCite this: J. Org. Chem. 1960, 25, 10, 1790–1797Publication Date (Print):October 1, 1960Publication History Published online1 May 2002Published inissue 1 October 1960https://pubs.acs.org/doi/10.1021/jo01080a031https://doi.org/10.1021/jo01080a031research-articleACS PublicationsRequest reuse permissionsArticle Views205Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A compact high selectivity seventh-order UWB bandpass filter with ultra-stopband attenuation (2012)

Based on a unique E-shape microstrip structure and its equivalent circuit, a compact and highly selective seventh-order UWB bandpass filter is developed for small wireless communication systems. This highly selective UWB bandpass filters offers ultra-wide stopband attenuation. The filter composes of six grounded middle stub E-shape microstrip structures connected in cascade using short sections of the microstrip line. The filter structure boosts reduced number of vias achieved by folding back the consecutive middle stubs in opposite direction. The proposed filter is smaller than 4.3 mm × 10 mm × 0.4 mm excluding the feeding ports. The theoretical and measured responses of the filter show excellent agreement.