gebhart/patrepeval huggingface dataset:
GMPOZ, a BTB/POZ Domain Nuclear Protein, is a Regulator of Hormone Responsive Gene Expression in Barley Aleurone (2004)

GAMYB is a GA-responsive activator of hydrolase gene expression in the aleurone layer of germinated cereal grains. We have isolated a putative GAMYB-binding protein, GMPOZ, which contains a BTB/POZ domain found in certain animal transcriptional regulators. Although BTB/POZ domain proteins are numerous in plants, very few are yet characterized. We found that GMPOZ is nuclear localized and that GMPOZ mRNA is expressed highly in anthers as well as aleurone. Transient silencing of the GMPOZ gene suggests that GMPOZ is involved in hormone responsive gene expression in aleurone.
Neutron diffraction by vibrating ADP crystals (1974)

The intensity of neutrons diffracted from ADP crystals is enhanced when the crystals are vibrated in their fundamental piezoelectric modes. The neutrons are also modulated at a frequency approximately twice that of the crystal frequency. These effects can be explained by the dynamical theory of diffraction and are similar to the effects of neutrons diffracted by piezoelectric quartz crystals.
Theoretical Study of the Reaction of Atomic Hydrogen with Acetonitrile (2000)

The reaction of atomic hydrogen with acetonitrile has been studied using the B3LYP and Gaussian-3 (G3) methods. The geometries and vibrational frequencies of various stationary points on the potential energy surface were calculated at the B3LYP level with the 6-311G(d,p) and 6-311++G(2d,2p) basis sets. The energetics were refined at the G3 level. The G3 barrier height has been calibrated using a test set including 39 well-established reactions. It is believed that the present potential energy surface is reliable within chemical accuracy. The title reaction starts in four manners, namely direct hydrogen abstraction, C-addition, N-addition, and substitution. The corresponding barrier heights (including ZPE corrections) are 12.0, 7.6, 9.6, and 44.7 kcal/mol, respectively. The kinetics of the reaction were studied using the TST and multichannel RRKM methodologies over the temperature range 300∼3000 K, and were compared with the earlier experimental data. At lower temperatures, the C-addition step is the most feasible channel, and the major products are CH3 and HCN at lower pressures. At higher temperatures, the direct hydrogen abstraction path leading to H2 and CH2CN is apparently dominant.
Thalidomide Analogues as Anticancer Drugs (2007)

The evolution of thalidomide as an effective treatment in several neoplasms has led to the search for compounds with increased antiangiogenic and anti-tumor effects, but decreased side-effects. The development of thalidomide analogues which retain the immunomodulatory effects of the parent compound, while minimizing the adverse reactions, brought about a class of agents termed the Immunomodulatory drugs (IMiDs). The IMiDs have undergone significant advances in recent years as evidenced by the recent FDA-approvals of one of the lead compounds, CC-5013 (lenalidomide), for 5q-myelodysplasia and for multiple myeloma (MM). Actimid (CC-4047), another IMiD lead compound, has also undergone clinical testing in MM. Apart from hematologic malignancies, these drugs are actively under investigation in solid tumor malignancies including prostate cancer, melanoma, and gliomas, in which potent activity has been demonstrated. The preclinical and clinical data relating to these analogues, as well as ENMD-0995, are reviewed herein. Encouraging results with these thalidomide analogues brought forth synthesis and screening of additional novel thalidomide analogues in the N-substituted and tetrafluorinated classes, including CPS11 and CPS49. This review also discusses the patents and preclinical findings for these agents.
Risk Factors for Lead Exposure in Adult Population in Southern Brazil (2014)

In Brazil there is no systematic evaluation to access blood lead levels (BLL) in the general population and few studies with adults have been published. The aim of this study was to examine the socioeconomic, environmental, and lifestyle determinants of BLL in the adult Brazilian population. In total, 959 adults, aged 40 years or more, were randomly selected in a city in southern Brazil. Information on socioeconomic, dietary, lifestyle, and occupational background was obtained by interviews. A spatial analysis was conducted to discern whether there were any identifiable sources of exposure. BLL were measured by inductively coupled plasma-mass spectrometry. There was an adjustment for gender, age, race, education, income class, smoking status, alcohol consumption, occupation, and red meat or cow milk consumption (Model 1), and for occupation and gender (Model 2). The geometric mean of BLL was 1.97 μg/dl (95% CI: 1.9-2.04 μg/dl). In Model 1, BLL were positively associated with male gender, older age, and drinking and smoking habits, and less frequently with milk consumption. In Model 2, data showed higher BLL in non-white than white participants, in former smokers and individuals with current or former employment in lead (Pb) industries. The participants living in the area with more Pb industries had higher BLL (3.3 μg/dl) compared with those residing in other areas with no or fewer Pb industries (1.95 μg/dl). Despite the low BLL found in adults living in an urban area, Pb industries need to be monitored and regulatory laws implemented to prevent metal contamination in urban settings.
Simplified atmospheric model for UAV simulation and evaluation (2017)

Purpose The purpose of this paper is to develop a simplified atmospheric model including constant wind, turbulence, gusts, and wind shear to provide simulation tools for unmanned aerial vehicle (UAV) design, testing, and evaluation within the West Virginia University (WVU) UAV simulation environment. Design/methodology/approach Analytical methods and experimental data are used to develop the simplified model for air mass motion as a superposition of four major components. Spatial gradients of relative air velocity vector projections are considered for modeling wind shear effects. The total contribution to relative air velocity from the four components in vehicle body axes is used within the WVU UAV simulation environment to calculate aerodynamic forces and moments. The simplified wind model is also interfaced with aircraft sub-system upset conditions models and different autonomous flight scenarios. Findings The simplified wind model developed provides simulation of different upset environment flight conditions with desirable levels of realism. It allows the testing, comparison, and evaluation of different trajectory tracking solutions for autonomous flight. Research limitations/implications The proposed simplified wind model facilitates the investigation of the effects of different atmospheric scenarios on the performance of trajectory generation algorithms and trajectory tracking control laws. Practical implications The proposed simplified wind model has been proved to be a high flexibility tool for simulation of UAVs under normal and abnormal flight conditions. It is expected to provide valuable support for the design and analysis of autonomous flight control laws. Originality/value This research effort provides a new capability for the advanced simulation of UAV autonomous flight with practically no additional computational cost. It adds an unprecedented level of detail and versatility to the UAV simulation toolkit within a very user-friendly framework aimed at supporting UAV design and analysis for optimal performance and safety under normal and abnormal flight conditions.
Predicting the Influence of Microvascular Structure On Tumor Response to Radiotherapy (2016)

By using realistic 3-D vessel network geometries this study shows that real and artificial network descriptions and assumptions of spatially uniform oxygen distributions lead to similar RT response predictions in relatively small tissue volumes. This suggests that either a more detailed description of oxygen transport in the microvasculature is required or that the oxygen enhancement ratio used in the well known linear-quadratic RT response model is relatively insensitive to microvascular structure.
Multivariate instrument standardization (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMultivariate instrument standardizationYongdong. Wang, David J. Veltkamp, and Bruce R. KowalskiCite this: Anal. Chem. 1991, 63, 23, 2750–2756Publication Date (Print):December 1, 1991Publication History Published online1 May 2002Published inissue 1 December 1991https://pubs.acs.org/doi/10.1021/ac00023a016https://doi.org/10.1021/ac00023a016research-articleACS PublicationsRequest reuse permissionsArticle Views1880Altmetric-Citations453LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Heterodyne single-pixel facility instrumentation for the APEX Telescope (2006)

APEX, the Atacama Pathfinder Experiment, is collaboration between Max Planck Institut fur Radioastronomie (MPIfR) with Astronomisches Institut Ruhr Universitat Bochum, Onsala Space Observatory and the European Southern Observatory (ESO). The telescope was supplied by VERTEX Antennentechnik in Duisburg, Germany, and is a 12 m antenna with 15 &#956;m rms surface accuracy operating at the Atacama Desert Llano Chajnantor, in the Chilean Andes at 5100 m altitude. APEX heterodyne single pixel facility receiver are placed in the telescope Nasmyth cabin A. The receivers are coupled to the antenna via relay optics providing possibility to operate either one of the two different PI-type instruments or a multi-channel facility heterodyne receiver to cover 211 - 1500 GHz frequency range. In this report, we present the optical design for APEX single-pixel facility heterodyne receiver providing frequency independent illumination of the secondary for all the receiver channels. We present design of the two-channel facility receiver APEX A, installed and operating since June 2005, and of the coming 6-channel APEX facility receiver. The report includes a brief review of the mixer technology development status for APEX Band 1, 211 - 270 GHz, using sideband separation technology (2SB), Band 2, 270 - 370 GHz, 2SB, Band 3, 385 - 500 GHz, 2SB, and Band T2, 1250 - 1390 GHz, HEB waveguide balanced mixer, those on the development at Onsala Space Observatory. We present description of the receiver control system and example observation of APEX 2a receiver.
Uniform β-SiC thin-film growth on Si by low pressure rapid thermal chemical vapor deposition (1992)

β-SiC thin films have been grown on Si by rapid thermal chemical deposition at reduced pressures (LP-RTCVD) as low as 5 Torr. The growth process involved the carbonization of the (100)Si surface by reaction with propane. Reducing the pressure resulted in a monotonic increase in growth rate. At a reaction temperature of 1300 °C, using 100 sccm of C3H8 (diluted to 5% in H2) and 0.9 lpm H2 carrier gas yielded a growth rate of 0.45 Å/s at 760 Torr and 18 Å/s at 5 Torr. A substantial increase in film thickness uniformity was observed at low pressure. At 5 Torr, the average thickness and standard deviation measured over the area of a 7.5 cm diam wafer were 1602 and 46 Å, respectively. This low standard deviation for LP-RTCVD, equivalent to 2.87% of the average thickness, is the result of uniform growth over the entire specimen, including the edge region. In contrast, atmospheric pressure RTCVD results in severely nonuniform growth in the vicinity of the wafer edge.
A Strategy for the Synthesis of Anthraquinone-Based Aryl-C-glycosides (2013)

An efficient and simple strategy for the synthesis of a diverse range of anthraquinone-based aryl-C-glycosides has been developed. It involves the sequential Diels–Alder reaction and oxidative aromatization with the preformed glycosyl diene and dienophiles. The glycosyl dienes were obtained from simple sugars by tandem one-pot substitution and elimination reaction.
Adaptive optics using a liquid crystal phase modulator in conjunction with a Shack-Hartmann wavefront sensor and zonal control algorithm (1998)

Multi-segment liquid crystal spatial light modulators have received much attention recently for use as high-precision wave-front control devices for use in astronomical and non- astronomical applications. They act much like piston only segmented deformable mirrors. In this paper we investigate the use of these devices in conjunction with a Shack- Hartmann wavefront sensor. In this paper we consider a zonal algorithm in order to take advantage of high speed matrix multiply hardware which we have in hand.
Guanidinylated Polymyxins as Outer Membrane Permeabilizers Capable of Potentiating Rifampicin, Erythromycin, Ceftazidime and Aztreonam against Gram-Negative Bacteria (2022)

Polymyxins are considered a last-line treatment against infections caused by multidrug-resistant (MDR) Gram-negative bacteria. In addition to their use as a potent antibiotic, polymyxins have also been utilized as outer membrane (OM) permeabilizers, capable of augmenting the activity of a partner antibiotic. Several polymyxin derivatives have been developed accordingly, with the objective of mitigating associated nephrotoxicity. The conversion of polymyxins to guanidinylated derivatives, whereby the L-γ-diaminobutyric acid (Dab) amines are substituted with guanidines, are described herein. The resulting guanidinylated colistin and polymyxin B (PMB) exhibited reduced antibacterial activity but preserved OM permeabilizing properties that allowed potentiation of several antibiotic classes. Rifampicin, erythromycin, ceftazidime and aztreonam were particularly potentiated against clinically relevant MDR Gram-negative bacteria. The potentiating effects of guanidinylated polymyxins with ceftazidime or aztreonam were further enhanced by adding the β-lactamase inhibitor avibactam.
Early Detection of Lung Disease and Its Association with the Nutritional Status, Genetic Background and Life Events in Patients with Cystic Fibrosis (2000)

Progression of lung disease is the most prominent cause of morbidity and death in patients with cystic fibrosis (CF), but the severity of lung disease and the rate of lung function decline are highly variable. An attempt was made to define accurate estimates of disease progression in these patients early diagnosed and prospectively evaluated until 10 years of age. The primary question to ask was whether functional abnormalities detected already in infancy are associated with functional derangements later on in life, and may be useful as parameters of prognostic value. Early diagnosis of CF can best be achieved by screening of mutation by new techniques (buccal cell brushing) in infants, even when the sweat test or accurate blood sampling is not available. Moreover, in infants lung function can be assessed by infant whole-body plethysmography enabling the study of the interrelationship with delayed weight gain and growth retardation, as well as the associations with the most common disease-causing mutations. Out of a cohort of 80 infants (39 males, 41 females) with CF a follow-up study was started with 50 CF infants diagnosed during infancy (mean age 4.6 +/- 4.0 months; range 0.1-12.7 months) and prospectively evaluated at 6-month intervals during the first 2 years of life. Moreover, in 32 CF children out of this cohort, follow-up was continued until 10 years of age. Differences were encountered with respect to the different events occurring during the first years of life, especially the onset of chronic colonization with Pseudomonas aeruginosa. The association between infant lung function and specific mutations (DeltaF508 homozygotes, frameshift DeltaF508/3905insT compound heterozygotes and nonsense DeltaF508/R553X compound heterozygotes) furthermore revealed that differences in lung function within the genetic groups are mainly related to the degree of pulmonary hyperinflation. Pulmonary hyperinflation was also associated with the degree of impaired nutritional status. An association between impaired gas exchange characteristics at 10 years of age and the degree of pulmonary hyperinflation during infancy finally demonstrates that by early mutation screening, lung function testing and assessment of the nutritional status predictors of disease progression later on in life can be defined. Therefore, preventive therapeutic measures should primarily be based on such prognostic factors.
Pichia pastoris Alcohol Oxidase 1 (AOX1) Core Promoter Engineering by High Resolution Systematic Mutagenesis (2017)

Unravelling the core promoter sequence-function relationship is fundamental for engineering transcription initiation and thereby a feasible "tuning knob" for fine-tuning expression in synthetic biology and metabolic engineering applications. Here a systematic replacement studies of the core promoter and 5' untranslated region (5'UTR) of the exceptionally strong and tightly methanol regulated Komagataella phaffii (syn. Pichia pastoris) alcohol oxidase 1 (AOX1) promoter at unprecedented resolution is performed. Adjacent triplets of the 200 bp long core promoter are mutated at a time by changing the wild-type sequence into cytosine or adenine triplets, resulting in 130 variants that are cloned upstream of an eGFP reporter gene providing a library for expression fine-tuning. Mutations in the TATA box motif, regions downstream of the transcription start site or next to the start codon in the 5'UTR had a significant effect on the eGFP fluorescence. Surprisingly, mutations in most other regions are tolerated, indicating that yeast core promoters can show a high tolerance toward small mutations, supporting regulatory models of degenerate motifs, or redundant design. The authors exploited these neutral core promoter positions, not affecting expression, to introduce extrinsic sequence elements such as cloning sites (allowing targeted core promoter/5'UTR modifications) and bacterial promoters (applicable in multi host vectors).
Acoustic noise pollution monitoring in an urban environment using a VANET network (2012)

The main objective of this work is the development of a Vehicle Ad Hoc NETwork (VANET) to collect data from GPS equipped mobile phones used as noise detectors. In this system, sensor nodes perioadically transmit acoustic noise levels to neighboring cars, data packets being shared and temporary stored by participating VANET nodes and ultimately forwarded to a collector node connected to the Internet, providing public real-time data. A routing technique called MP-OLSR that takes into account the spatially separation between the multiple paths is used, for better transmission reliability and congestion avoidance as well as for control message overhead minimization.
Does radioiodine therapy have disadvantageous effects in non‐iodine accumulating differentiated thyroid carcinoma? (2002)

We did not find disadvantageous effects of a single radioiodine therapy on serum thyroglobulin increments in patients with negative post-therapeutic whole body scintigraphy. However, as we did not observe a beneficial effect either, we would not advise the continuation of radioiodine therapy in patients with negative post-therapeutic whole-body scintigraphy, unless a positive response is observed in individual cases.
Malignant Intracerebral Nerve Sheath Tumors: A Case Report with Review of the Literature (2013)

The occurrence of benign nerve sheath tumors within the neuroaxis is uncommon. Even rarer is the finding within brain parenchyma, termed malignant intracerebral nerve sheath tumors (MINST). We present a case of MINST which occurred in the frontal lobe of an 18-year-old male that recurred almost 4 years later. Imaging demonstrated a 4.0 cm lesion with an associated mass effect. He underwent a right fronto-parietal craniotomy for gross total resection. Pathology was inconclusive with a Glioblastoma Multiforme (GBM) as the most likely diagnosis, though gliosarcoma and MINST were also highly considered. Postoperatively, he was treated with chemotherapy and radiation and followed for almost 4 years, when an MRI indicated a recurrence. Resection of the recurrence was highly suggestive of MINST. Surgery was followed by radiation and chemotherapy, but, less than 7 months later, he was readmitted for a surgical-site infection, and, after multiple surgeries, and his family terminated care. Recognizing this unusual tumor in the differential diagnosis of a heterogeneously enhancing intracerebral mass can help surgeons diagnose and treat it. This report also exhaustively reviews the literature and presents diagnostic and treatment strategies.
Multi-modal 2D-3D non-rigid registration (2006)

In this paper, we propose a multi-modal non-rigid 2D-3D registration technique. This method allows a non-rigid alignment of a patient pre-operatively computed tomography (CT) to few intra operatively acquired fluoroscopic X-ray images obtained with a C-arm system. This multi-modal approach is especially focused on the 3D alignment of high contrast reconstructed volumes with intra-interventional low contrast X-ray images in order to make use of up-to-date information for surgical guidance and other interventions. The key issue of non-rigid 2D-3D registration is how to define the distance measure between high contrast 3D data and low contrast 2D projections. In this work, we use algebraic reconstruction theory to handle this problem. We modify the Euler-Lagrange equation by introducing a new 3D force. This external force term is computed from the residual of the algebraic reconstruction procedures. In the multi-modal case we replace the residual between the digitally reconstructed radiographs (DRR) and observed X-ray images with a statistical based distance measure. We integrate the algebraic reconstruction technique into a variational registration framework, so that the 3D displacement field is driven to minimize the reconstruction distance between the volumetric data and its 2D projections using mutual information (MI). The benefits of this 2D-3D registration approach are its scalability in the number of used X-ray reference images and the proposed distance that can handle low contrast fluoroscopies as well. Experimental results are presented on both artificial phantom and 3D C-arm CT images.
Development of a Virtual Model and Experimental Simulator for the Human Cervical Spine (2006)

In this study, we introduced a virtual model and experimental simulator applicable to kinematics and kinetics analyses of the human cervical spine. The geometry of cervical vertebrae was created from computer tomography images. The disc joints were modeled as load-based joints having non-linear viscoelastic properties defined by data from in vitro experiments. The facet joints were modeled to rotate freely and translate along facet planes. Ligaments were modeled as nonlinear spring-damper elements. Simulated testing of the virtual model was conducted and the global stiffness response passed all of the statistical comparison tests. The model provided realistic visualization of in vitro experimental protocol.