gebhart/patrepeval huggingface dataset:
Phased array theory and technology (1981)

This review of array antennas highlights those elements of theory and hardware that are a part of the present rapid technological growth. The growth and change in array antennas include increased emphasis on special-purpose array techniques such as conformal and printed circuit arrays, wide angle scanning arrays, techniques for limited sector coverage, and antennas with dramatically increased pattern control features such as low sidelobe, adaptively controlled patterns. These new topics have substantially replaced large radar arrays in the literature and constitute a major change in the technology. The paper presents a tutorial review of theoretical developments emphasizing techniques appropriate to finite arrays, but indicating parallel developments in infinite array theory, which has become the useful tool for analysis of large arrays. A brief review of the theory of ideal arrays is followed by a generalized formulation of array theory including mutual coupling effects, and is appropriate to finite or infinite arrays of arbitrary wire elements or apertures in the presence of a conducting ground screen. Some results of array tolerance theory are summarized from the literature and retained as reference throughout discussions of array component requirements and device tolerance for low sidelobe arrays. Examples from present technology include conformal and hemispherical coverage arrays, lightweight printed circuit arrays, systems for use with reflectors and lenses in limited sector coverage applications, and wide-band array techniques.
A Two-Step Synthesis Of S-Methyl Dinucleoside Phosphorothioates (1988)

Abstract S-methyl dinucleoside phosphorothioates are prepared from 0-2,4-dichlorophenyl S-methyl nucleoside phosphorothioates by selective removal of the transient 0-2,4-dichlorophenyl protecting group followed by condensation with appropriate nucleosides in the presence of MSNT activating reagent.
ERK1 phosphorylates Nanog to regulate protein stability and stem cell self-renewal (2014)

Nanog regulates human and mouse embryonic stem (ES) cell self-renewal activity. Activation of ERKs signaling negatively regulates ES cell self-renewal and induces differentiation, but the mechanisms are not understood. We found that ERK1 binds and phosphorylates Nanog. Activation of MEK/ERKs signaling and phosphorylation of Nanog inhibit Nanog transactivation, inducing ES cell differentiation. Conversely, suppression of MEK/ERKs signaling enhances Nanog transactivation to inhibit ES cell differentiation. We observed that phosphorylation of Nanog by ERK1 decreases Nanog stability through ubiquitination-mediated protein degradation. Further, we found that this phosphorylation induces binding of FBXW8 with Nanog to reduce Nanog protein stability. Overall, our results demonstrated that ERKs-mediated Nanog phosphorylation plays an important role in self-renewal of ES cells through FBXW8-mediated Nanog protein stability.
Full waveform accuracy to estimate delay in coupled digital circuits (2008)

It is very natural that the signal waveform becomes non-monotonic at the presence of coupling noise. Therefore, the signal delay can only be precisely predicted through using full waveform accuracy. This paper proposes an efficient algorithm to accurately estimate the delay time of global interconnects driven by gates through estimating the output waveform. Experimental results show that only a little more than 5% mean error is induced while, on average, the running time of the proposed algorithm is more than 370 times faster than HSPICE simulation.
Measuring reuse of SAP requirements (1999)

Reusing SAP R/3 business requirements has been recognized as the most promising strategy to shorten the time-to-production and increase the quality of the conceptual design in R/3 implementation projects. However, very little research has been conducted to actually quantify and really estimate the results from SAP R/3 requirement reuse the customers have achieved. This paper deals with the identification and the measurement of reuse in the requirements conceptualization phase of the SAP R/3 component configuration cycle. We present a systematic approach based on standard functional size measurement practices. We introduce two key concepts: SAP requirements reuse levels and reuse indicators. The reuse levels serve to classify SAP requirements based on the extent to which the requirements are reused in a R/3 implementation project. The reuse indicators are then built to quantify the requirement reuse the company has achieved. An experimental case study illustrates the applicability of the approach. Finally, some validation issues are addressed.
A microwave lens for a flat-plate DBS antenna (1989)

A flat-plate antenna may be a viable alternative to a parabolic dish for the reception of Direct Broadcast by Satellite (DBS) transmissions. The antenna could either be mounted flat on a wall and its beam steered to point at one satellite, or it could be configured to receive more than one satellite at a time. It is imperative, however, that such a device can be made using low-cost materials and production techniques so that is could compete with a parabolic dish in a consumer market. An experimental antenna has been designed, constructed and measured. It consists of a polariser, a planar array of linear elements, and a beamforming network to steer the beam of the array.
Ecology of Fish-Virus and Control of Viral Diseases (1978)

Prior to this presentation on preventive measures against fish communicable diseases being theme of this symposium or against fish viral diseases in this subject, the author presents some comments on fish-virus ecology in fish community as the first chapter, subsequently he transfers to the second involving the preventive measures.In the first chapter the author points out that two transmission of vertical and horizontal infection involve in fish viral contagions and the sexual products coming from latently IPN-infected male brood make the vertical transmission spread easily by artificial fertilization with the products which never contain neutralizing antibody to IPNV.In the second he reviews on the virucidal effects of iodine phore, hard water or salt water and a derivative of an ascorbic acid(unpublished)and on the effect of ultraviolet irradiation as well as prophyractic effects to IPN, IHN, VHS by means of artificial active immunity, and on interferon efficacy. He emphasizes that the combined measures with active immunity and an interferon are worthy to be put in an idea as one of the prophyractic measures against viral epizootics occurring at an early stage in the developement of fish like the host of IPN, IHN and others.He stresses that the preventive measures employed can be polytechnic and must impose two significances of controlling the virus in the environmental water for fishes and of inactivating the agent invaded in the animals. The former can be fulfilled with environmental hygienic technology involved using disinfectants or virucidals as the chemical treatment and ultraviolet irradiation as the physical. The latter can be or may be achieved with artificially enhanced fish physiological activity like artificial immunity and artificial interferon induction as well as these combined measures.
Fabrication of High Surface Area Fibrous TiO2 with Well-defined Mesostructures via a Nonsurfactant Approach (2002)

Abstract Fibrous anatase titania with a high surface area and well-defined mesostructures has been prepared by precipitating of titanium tetrachloride (TiCl4) with ammonia in the presence of acetic acid as the liquid dispersion medium.
Myelin deficiencies in both the central and the peripheral nervous systems associated with aSOX10 mutation (1999)

We describe an unique patient presenting with severe leukodystrophy compatible with Pelizaeus-Merzbacher disease and peripheral neuropathy consistent with Charcot-Marie-Tooth disease type 1 in addition to Waardenburg-Hirschsprung syndrome. A novel mutation was identified in her SOX10 gene, which encodes a transcription factor preferentially expressed in the late embryonic glial cell lineage and in mature myelin-forming cells of both the central nervous system and peripheral nervous system, as well as in the early neural crest cells. Heterozygous SOX10 loss-of-function mutations have been reported in patients with Waardenburg-Hirschsprung syndrome and its murine model, Dominant megacolon. However, neither Waardenburg-Hirschsprung syndrome patients nor Dominant megacolon mice have dysmyelinating features, suggesting the question of how SOX10 acts in the glial lineage in vivo. The novel mutation described herein does not disrupt the coding region but extends the peptide and hence is likely to act as a dominant-negative allele. Our findings indicate that dysfunction of SOX10 may lead to deficiency of myelination in the central nervous system and peripheral nervous system as well as hypopigmentation and enteric aganglionosis.
Developmental regulation of the toxin sensitivity of Ca(2+)-permeable AMPA receptors in cortical glia (1996)

We examined the properties of glutamate agonist-induced Ca2+ fluxes in cultured CG-4 and O-2A progenitor cells from rat cortex. Kainate-induced Ca2+ fluxes in these cells were found to be attributable to the activation of AMPA receptors. Thus, these fluxes were enhanced by cyclothiazide but not by concanavalin A and were blocked completely by GYKI-53655. We simultaneously examined kainate-induced Ca2+ entry and Na+ currents in these cells under voltage-clamp conditions. Both of these parameters were blocked by Joro spider toxin (JSTx) in undifferentiated cells. However, neither JSTx nor Argiotoxin 636 effectively blocked either parameter in cells differentiated into type II astrocytes. This change in toxin sensitivity occurred slowly over a period of several days. Similar results were obtained in Ca(2+)-imaging studies. When cells were differentiated into oligodendrocytes, they showed an intermediate sensitivity to block by JSTx as assessed using imaging and voltage-clamp studies. Analysis of the expression of AMPA-receptor subunits showed an increase in the concentration of glutamate receptor-2 (GluR2) in CG-4 cells as they differentiated into type II astrocytes and oligodendrocytes. These results demonstrate that the AMPA receptors in cells of the O-2A lineage flux appreciable amounts of Ca2+ but may contain variable amounts of edited GluR2 subunits.
A multielement high power monopulse feed with low sidelobe and high aperture efficiency (1974)

A multielement high power monopulse feed was investigated for excitation of a phased array. This feed has the advantages of high antenna efficiency, effective independent sidelobe control for the sum and difference patterns, and high power handling capability. A 32-element device has been designed which yields theoretical sidelobe levels less than -31 dB for both the sum and difference patterns over the 2800 to 3200 MHz frequency band. The aperture efficiency is 69.5 percent which includes 0.1 dB spillover loss and 1.40 dB tapering loss. The difference slope efficiency defined as the actual slope gain over the maximum possible value is 50 percent at midband. An experimental feed was constructed to verify the predicted performance characteristics. Measured data on both the radiation patterns and the antenna gain agreed very Well with the analytical results. The measured sidelobe level is below -30 dB for all sum and difference beams over the 2800 to 3200 MHz. In addition, this feed can be designed for low power intensity at the feed aperture so that very high power operation can be attained.
Schistosoma mansoni eggs induce antigen-responsive CD44-hi T helper 2 cells and IL-4-secreting CD44-lo cells. Potential for T helper 2 subset differentiation is evident at the precursor level (1992)

Schistosoma mansoni eggs are potent inducers of biased Th2-like immune responses. Using a model system where mice are immunized with isolated schistosome eggs, we demonstrate that CD44 expression, up-regulation of which has been linked to Th cell development, is increased on Th2 cells. We also investigate the functional properties of CD44-lo Th cells recovered from the overtly Th2 environment constituted by lymph nodes draining sites of egg deposition. Production of high levels of IL-4, IL-5, and IL-10 by Th cells responding to egg Ag is shown to be the property of a subpopulation expressing CD44-hi. This population of Th cells cosegregates with a blasting subpopulation expressing more IL-4R (but similar amounts of IL-2R) than Th cells from normal mice. These results indicate that mature Th2 cells responding to schistosome eggs are CD44-hi and suggest that they use IL-4 as a growth factor. In contrast, CD44-lo cells sorted from lymph node populations responding to eggs are able to produce small amounts of IL-4 and IL-2, but no IL-5 or IL-10. This is surprising, because low expression of CD44 is considered a characteristic of Th cell naivite and concomitant ability to produce only IL-2. Thus, in lymph nodes responding to schistosome eggs, potential for Th2 subset differentiation is evident within the CD44-lo precursor Th subpopulation.
Dielectric Properties of Polypeptide Solutions. III. Elucidation of the Critical Frequency of Dielectric Dispersion from the Molecular Shape of the α Helix (1959)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Akiyoshi Wada; Dielectric Properties of Polypeptide Solutions. III. Elucidation of the Critical Frequency of Dielectric Dispersion from the Molecular Shape of the α Helix. J. Chem. Phys. 1 January 1959; 30 (1): 329–330. https://doi.org/10.1063/1.1729912 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioThe Journal of Chemical Physics Search Advanced Search |Citation Search
Modeling and Simulation for Mission Operations Work System Design (2003)

Work System analysis and design is complex and non-deterministic. In this paper we describe Brahms, a multiagent modeling and simulation environment for designing complex interactions in human-machine systems. Brahms was originally conceived as a business process design tool that simulates work practices, including social systems of work. We describe our modeling and simulation method for mission operations work systems design, based on a research case study in which we used Brahms to design mission operations for a proposed discovery mission to the Moon. We then describe the results of an actual method application project-the Brahms Mars Exploration Rover. Space mission operations are similar to operations of traditional organizations; we show that the application of Brahms for space mission operations design is relevant and transferable to other types of business processes in organizations.
Expression of recombinant soluble Fc epsilon RI: function and tissue distribution studies. (1995)

Recombinant soluble IgE Fc receptors (rsFc epsilon RI) are potent inhibitors of type I hypersensitivity reactions tested in a local inflammatory setting. However, the fate of these receptors in vivo is dependent on the cellular source of the rsFc epsilon RI. We have produced these by transiently transfecting Cos-7 cells with a cDNA encoding the extracellular domains of human Fc epsilon RI alpha-chain. Following affinity purification, the rsFc epsilon RI was characterized as 58,000 MW, which was reduced to 23,000 MW following endoglycosidase F treatment. The purified rsFc epsilon RI could inhibit mouse IgE binding to Fc epsilon RI+ transfected CHO-K1 cells in vitro, bind sIgE+ B lymphoma cells in vitro, and inhibit the passive cutaneous anaphylaxis model in vivo in Sprague-Dawley rats. Pharmacokinetic studies in vivo involving intravenous injection of radiolabelled rsFc epsilon RI in mice revealed the receptor to have a rapid initial blood clearance (t1/2 early phase of 15 min) and to accumulate in the liver before being detected in urine. The localization of rsFc epsilon RI in the liver could be blocked by administration of mannose glycosylated ovalbumin and mannan, demonstrating that liver uptake involved the mannose receptor that is expressed on liver sinusoid cells and Kupffer cells. The production of rsFc epsilon RI using a stable expression system in CHO-K1 cells produced functional receptor of the same molecular weight as the Cos-7 system by sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE). However, biodistribution studies demonstrated differences; the CHO-K1 cell-produced material did not localize to the liver in comparison to the Cos-7-produced rsFc epsilon RI.
Conserved expression of a TASSELSEED2 homolog in the tapetum of the dioecious Silene latifolia and Arabidopsis thaliana (1997)

To investigate the genetics of male sex determination and stamen development in the dioecious plant Silene latifolia (white campion), male-specific transcripts were isolated from developing flowers by cDNA subtraction. One of the cDNAs identified, STA1, had high DNA and amino acid sequence homology to the male sex determining gene of Zea mays (maize), TASSELSEED2. Both genes are expressed in male and not in female flowers, However, they do not share the same expression pattern. The TASSELSEED2 gene product is expressed in the gynoecium primordia of male maize flowers where it is necessary for pistil abortion. STA1 is not expressed in the gynoecium primordia of male white campion and therefore its gene product cannot perform the same function in sex determination that TASSELSEED2 performs in maize. STA1 is expressed in tapetal cells of white campion male flowers and of white campion hermaphroditic mutants. A homologous gene is also expressed in the tapetum of hermaphroditic Silene species. Tapetal expression of a homologous gene (named ATA1) was also found in Arabidopsis thaliana. The similarity in primary sequence and expression pattern of STA1 and ATA1 indicate that these genes have a conserved role in tapetum development.
Fermented Wheat Germ Extract Inhibits Glycolysis/Pentose Cycle Enzymes and Induces Apoptosis through Poly(ADP-ribose) Polymerase Activation in Jurkat T-cell Leukemia Tumor Cells (2002)

The fermented extract of wheat germ, trade name Avemar, is a complex mixture of biologically active molecules with potent anti-metastatic activities in various human malignancies. Here we report the effect of Avemar on Jurkat leukemia cell viability, proliferation, cell cycle distribution, apoptosis, and the activity of key glycolytic/pentose cycle enzymes that control carbon flow for nucleic acid synthesis. The cytotoxic IC(50) concentration of Avemar for Jurkat tumor cells is 0.2 mg/ml, and increasing doses of the crude powder inhibit Jurkat cell proliferation in a dose-dependent fashion. At concentrations higher than 0.2 mg/ml, Avemar inhibits cell growth by more than 50% (72 h of incubation), which is preceded by the appearance of a sub-G(1) peak on flow histograms at 48 h. Laser scanning cytometry of propidium iodide- and annexin V-stained cells indicated that the growth-inhibiting effect of Avemar was consistent with a strong induction of apoptosis. Inhibition by benzyloxycarbonyl-Val-Ala-Asp fluoromethyl ketone of apoptosis but increased proteolysis of poly(ADP-ribose) indicate caspases mediate the cellular effects of Avemar. Activities of glucose-6-phosphate dehydrogenase and transketolase were inhibited in a dose-dependent fashion, which correlated with decreased (13)C incorporation and pentose cycle substrate flow into RNA ribose. This decrease in pentose cycle enzyme activities and carbon flow toward nucleic acid precursor synthesis provide the mechanistic understanding of the cell growth-controlling and apoptosis-inducing effects of fermented wheat germ. Avemar exhibits about a 50-fold higher IC(50) (10.02 mg/ml) for peripheral blood lymphocytes to induce a biological response, which provides the broad therapeutic window for this supplemental cancer treatment modality with no toxic effects.
The Functions of Educational Research (1990)

I n 1969, just a little over 20 years ago, Lee J. Cronbach and Patrick Suppes coedited a book entitled Research for Tomorrow's Schools in which they drew a distinction between two kinds of research, each of which they portrayed as having an important bearing on education. The first of these they called decision-oriented inquiry, the second, conclusion-oriented. Here is how they described the difference:
Peptidase profiles from non-albicans Candidaspp. isolated from the blood of a patient with chronic myeloid leukemia and another with sickle cell disease (2007)

Candida lipolytica and Candida rugosa were isolated from blood samples from a patient with chronic myeloid leukemia (31 years old) and a patient with sickle cell disease (1-year-old), respectively. Isolates were grown for 48 h at 37 degrees C in either Sabouraud or tryptone soy broth (TSB). Peptidases were tested for using substrate sodium dodecyl sulfate-polyacrylamide gels with gelatin, casein, bovine serum albumin (BSA) or hemoglobin. Enzymography analyses were made on the following substrates: human albumin, IgG and human fibrinogen, which had been incubated with the concentrated supernatants. For C. lipolytica, a approximately 60-kDa gelatin-degrading serine proteolytic activity was found in the TSB supernantant as well as a metallopeptidase activity capable of hydrolysing human albumin, IgG and human fibrinogen. With C. rugosa, albumin, IgG and human fibrinogen substrates were degraded by an aspartyl-like peptidase activity. Supernatants from C. rugosa also showed three serine proteolytic activities towards gelatin (approximately 50 kDa, TSB), casein ( approximately 94 kDa, TSB) and BSA ( approximately 120-kDa, Sabouraud), in addition to a metallopeptidase capable of degrading casein ( approximately 110 kDa, Sabouraud). Little is known about peptidases of C. rugosa and C. lipolytica and this preliminary data may prove useful for future work on host-parasite relationship and antifungal agents.
Three-dimensional glacier surface motion maps at the Gjálp eruption site, Iceland, inferred from combining InSAR and other ice-displacement data (2002)

Abstract We use topographically corrected interferograms, repeated global positioning system observations of locations of stakes and time series of elevation data to produce time series of high-resolution three-dimensional (3-D) ice surface motion maps for the infilling of the ice depression created by the 1996 subglacial eruption at the Gjálp volcano in Vatnajökull, Iceland. The ice inflow generated uplift in the central parts of the depression. During the first months, the uplift was much reduced by basal melting as the subglacial volcano cooled. For those motions surface-parallel ice flow cannot be assumed. The 3-D motion maps are created by an optimization process that combines the complementary datasets. The optimization is based on a Markov random-field regularization and a simulated annealing algorithm. The 3-D motion maps show the pattern of gradually diminishing ice flow into the depression. They provide a consistent picture of the 3-D motion field, both spatially and with time, which cannot be seen by separate interpretation of the complementary observations. The 3-D motion maps were used to calculate the cooling rate of the subglacial volcano for the first year after the eruption. First an uplift rate resulting solely from the inflow of ice was calculated from inferred horizontal motions. Basal melting was then estimated as the difference between the calculated uplift generated by the inflow of ice, and the observed uplift that was the combined result of ice inflow and basal melting. The basal melting was found to decline from 55 m 3 s –1 (due to power of 18 GW) in January 1997 to 5 m 3 s –1 (2GW) in October 1997.