gebhart/patrepeval huggingface dataset:
Effects of Granulated Blast Furnace Slag in the Engineering Behaviour of Stabilized Soft Soil (2013)

The paper evaluated the potential of granulated blast furnace slag (GBS) to stabilize a soft soil. Soft soil samples were collected from Tatibandh-Atari, rural road of Raipur, Chhattisgarh. This soil was classified as CI-MI as per Indian standard classification system (ISCS). Different amounts of GBS, i.e., 3, 6, 9 and 12% were used to stabilize the soft soil. The performance of GBS stabilized soils was evaluated using physical and strength performance tests namely, plasticity index, specific gravity, free swelling index, compaction, swelling pressure, california bearing ratio (CBR) and unconfined compressive strength (UCS). Based on strength performance tests, optimum amount of GBS was determined as 9%. Moreover, results indicate that inclusion of GBS increases the strength of soft soils, for example, UCS of 9% GBS modified soil was found approximately 28% higher compared to raw soil. Similarly, significant improvement has been observed for unsoaked and soaked CBR value of soils.
Multiple-Complex Coefficient-Filter-Based PLL for Improving the Performance of Shunt Active Power Filter under Adverse Grid Conditions (2018)

In recent years, shunt active power filters (SAPFs) are becoming a popular solution for power quality issues. A crucial part in synchronizing the SAPFs is the accurate estimation of the grid phase/frequency. The multiple-complex coefficient-filter-based PLL (MCCF-PLL) has interesting features under adverse grid conditions. The unique distinction of the MCCF-PLL from other PLLs is the ability of providing information about the sequence (polarity) of each individual frequency. However, the MCCF-PLL has not received much attention in APFs. In this paper, a study and an implementation of a selective harmonic cancelation technique based on MCCF-PLL to the SAPF is suggested. The proposed method proved its reliability and robust behavior in optimizing the performance of the SAPF under unbalanced and distorted grid conditions. The reliability of the proposed method is verified experimentally.
ChemInform Abstract: Reduction with 2‐Propanol Over Hydrous Tin(IV) Oxide. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
New biomarkers for drug‐induced liver injury (2018)

Potential conflict of interest: Nothing to report. Author names in bold designate shared co‐first authorship. TO THE EDITOR: As a researcher developing biomarkers for drug‐induced liver injury (DILI), the new Hepatology paper by Church et al. was of great interest.1 This important publication presents data regarding biomarkers that were measured in healthy subjects and patients with DILI. Church et al. state in their abstract that “glutamate dehydrogenase (GLDH) appears to be more useful than microRNA‐122 (miR‐122) in identifying DILI patients.” The data presented do not robustly justify such a strong statement. Indeed, studies of acetaminophen‐DILI report the opposite finding.2 The conclusion from Church et al. is derived from GLDH having a stronger correlation with ALT than miR‐122. This should be expected given that miR‐122 has different circulating kinetics to ALT and GLDH, being released before the serum ALT is increased and normalizing before ALT.3 Prospective studies, with samples collected serially, are necessary to conclusively determine the utility of miR‐122 or GLDH in identifying DILI. Church et al. express surprise at the variability in miR‐122 within and across healthy subjects. There are questions regarding their miR‐122 analysis, the answers to which will help readers interpret the significance of this variability. The investigators state that multiple samples from healthy subjects had undetectable miR‐122. This is surprising because miR‐122 is one of the highest abundance circulating microRNAs. Our MAPP/BIOPAR study included 1,187 patients.2 All these patients had miR‐122 concentrations measurable by PCR, including those without DILI. A failure to detect miR‐122 may reflect sample degradation, especially given that some of the samples used by Church et al. were stored for multiple years. In an attempt to mitigate any effect of degradation, in MAPP/BIOPAR, we measured an internal “normalizer” microRNA (let‐7d). By contrast, in the study by Church et al., only an exogenous spike‐in control was used. This strategy can only correct for differences in microRNA extraction and cannot correct for sample degradation. It would be informative to know the range of PCR Cq values from the healthy subjects and whether they correlated with sample age, sample storage, or the site of sample processing and measurement. Finally, it would be reassuring if the reported variability in miR‐122 persisted when normalized by let‐7d. MicroRNAs are a new reservoir for the discovery of circulating biomarkers. They behave differently to proteins. More information regarding important methodological issues would alleviate concerns that the variability in miR‐122 is a result of its analytical complexity.
Validation of Flavivirus Infectious Clones Carrying Fluorescent Markers for Antiviral Drug Screening and Replication Studies (2023)

ABSTRACT Flaviviruses have emerged as major arthropod-transmitted pathogens and represent an increasing public health problem worldwide. High-throughput screening can be facilitated by the use of viruses that express easily detectable marker proteins. Developing molecular tools such as reporter-carrying versions of flaviviruses for studying viral replication and screening of antiviral compounds therefore represents a top priority. However, the engineering of flaviviruses carrying either fluorescent or luminescent reporters remains challenging due to the genetic instability caused by marker insertion; therefore, new approaches to overcome these limitations are needed. Here, we describe reverse genetic methods which includes design and validation of infectious clones of Zika, Kunjin and Dengue viruses harboring different reporter genes for infection, rescue, imaging and morphology using super-resolution microscopy. It was observed that for different flaviviruses constructs with identical design displayed strikingly different genetic stability while corresponding virions resembled wild-type virus particles in shape and size. A successful strategy was assessed to increase stability of rescued reporter virus and permit antiviral drug screening based on quantitative automated fluorescence microscopy and replication studies.
Message Sequence Charts (2006)

Message sequence charts (MSCs) constitute an attractive visual formalism that is widely used to capture system requirements during the early design stages in domains such as telecommunication software. A version of MSCs called sequence diagrams is one of the behavioral diagram types adopted in the UML. In this chapter we survey MSCs and their extensions. In particular, we discuss high level MSCs, which allow MSCs to be combined in various regular ways, and the more recent mechanism of communicating transaction processes, which can be used to structure sequence charts to capture system behaviors more directly. We also discuss in some detail live sequence charts (LSCs), a multi-modal extension of MSCs with considerably richer expressive power, and the play-in/out method that makes it possible to use LSCs directly as an executable specification.
Granule Cell Ascending Axon Excitatory Synapses onto Golgi Cells Implement a Potent Feedback Circuit in the Cerebellar Granular Layer (2013)

The function of inhibitory interneurons within brain microcircuits depends critically on the nature and properties of their excitatory synaptic drive. Golgi cells (GoCs) of the cerebellum inhibit cerebellar granule cells (GrCs) and are driven both by feedforward mossy fiber (mf) and feedback GrC excitation. Here, we have characterized GrC inputs to GoCs in rats and mice. We show that, during sustained mf discharge, synapses from local GrCs contribute equivalent charge to GoCs as mf synapses, arguing for the importance of the feedback inhibition. Previous studies predicted that GrC-GoC synapses occur predominantly between parallel fibers (pfs) and apical GoC dendrites in the molecular layer (ML). By combining EM and Ca(2+) imaging, we now demonstrate the presence of functional synaptic contacts between ascending axons (aa) of GrCs and basolateral dendrites of GoCs in the granular layer (GL). Immunohistochemical quantification estimates these contacts to be ∼400 per GoC. Using Ca(2+) imaging to identify synaptic inputs, we show that EPSCs from aa and mf contacts in basolateral dendrites display similarly fast kinetics, whereas pf inputs in the ML exhibit markedly slower kinetics as they undergo strong filtering by apical dendrites. We estimate that approximately half of the local GrC contacts generate fast EPSCs, indicating their basolateral location in the GL. We conclude that GrCs, through their aa contacts onto proximal GoC dendrites, define a powerful feedback inhibitory circuit in the GL.
An indexed catalogue of publications on molluscan type specimens (1992)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
Figure S3 from Cancer Cell–Derived Matrisome Proteins Promote Metastasis in Pancreatic Ductal Adenocarcinoma (2023)

&lt;p&gt;Xenograft tumors knocked down and overexpressing AGRN, SERPINB5, and CSTB show expected protein expression changes.&lt;/p&gt;
CP-FPGA: Computation data-aware software/hardware co-design for nonvolatile FPGAs based on checkpointing techniques (2016)

With the booming trend of internet of things (IoT), reconfigurable devices, such as FPGAs, have drawn lots of attentions due to their flexible and high-performance capability. However, commercial FPGAs suffer from high leakage power consumption, which makes zero-leakage nonvolatile FPGA (nvFPGA) promising. This paper proposes a hardware/ software co-design based nvFPGA with efficient checkpointing strategy. With nonvolatile checkpointing BRAM (CBRAM), it maintains both computation data as well as configuration when power-off to avoid expensive rollbacks due to data loss. A checkpointing location-aware technique is used to balance computation rollback overheads and backup energy. Experimental results show that the proposed checkpointing strategy can reduce 45.8% backup data of nvFPGA when system-level power gating happens.
Probabilistic Graph Layout for Uncertain Network Visualization (2016)

We present a novel uncertain network visualization technique based on node-link diagrams. Nodes expand spatially in our probabilistic graph layout, depending on the underlying probability distributions of edges. The visualization is created by computing a two-dimensional graph embedding that combines samples from the probabilistic graph. A Monte Carlo process is used to decompose a probabilistic graph into its possible instances and to continue with our graph layout technique. Splatting and edge bundling are used to visualize point clouds and network topology. The results provide insights into probability distributions for the entire network-not only for individual nodes and edges. We validate our approach using three data sets that represent a wide range of network types: synthetic data, protein-protein interactions from the STRING database, and travel times extracted from Google Maps. Our approach reveals general limitations of the force-directed layout and allows the user to recognize that some nodes of the graph are at a specific position just by chance.
Cysteine Biosynthesis Pathway in the Archaeon Methanosarcina barkeri Encoded by Acquired Bacterial Genes? (2000)

The pathway of cysteine biosynthesis in archaea is still unexplored. Complementation of a cysteine auxotrophic Escherichia coli strain NK3 led to the isolation of the Methanosarcina barkeri cysK gene [encoding O-acetylserine (thiol)-lyase-A], which displays great similarity to bacterial cysK genes. Adjacent to cysK is an open reading frame orthologous to bacterial cysE (serine transacetylase) genes. These two genes could account for cysteine biosynthesis in this archaeon. Analysis of recent genome data revealed the presence of bacteria-like cysM genes [encoding O-acetylserine (thiol)-lyase-B] in Pyrococcus spp., Sulfolobus solfataricus, and Thermoplasma acidophilum. However, no orthologs for these genes can be found in Methanococcus jannaschii, Methanobacterium thermoautotrophicum, and Archaeoglobus fulgidus, implying the existence of unrecognizable genes for the same function or a different cysteine biosynthesis pathway.
Modulation of Buried Ionizable Groups in Proteins with Engineered Surface Charge (2010)

Recent work has shown that proteins can tolerate hydrophobic-to-ionizable-residue mutations. Here, we provide experimental evidence that the essential properties (pK value, protonation state, local dynamics) of buried ionizable groups in proteins can be efficiently modulated through the rational design of the surface charge distribution, thus paving the way for the protein engineering exploitation of charge burial.
The voice conveys emotion in ten globalized cultures and one remote village in Bhutan. (2015)

With data from 10 different globalized cultures and 1 remote, isolated village in Bhutan, we examined universals and cultural variations in the recognition of 16 nonverbal emotional vocalizations. College students in 10 nations (Study 1) and villagers in remote Bhutan (Study 2) were asked to match emotional vocalizations to 1-sentence stories of the same valence. Guided by previous conceptualizations of recognition accuracy, across both studies, 7 of the 16 vocal burst stimuli were found to have strong or very strong recognition in all 11 cultures, 6 vocal bursts were found to have moderate recognition, and 4 were not universally recognized. All vocal burst stimuli varied significantly in terms of the degree to which they were recognized across the 11 cultures. Our discussion focuses on the implications of these results for current debates concerning the emotion conveyed in the voice.
Primary Tracheal Lymphoma as a Rare Cause of Focal Tracheal Stenosis in an HIV-negative Patient (2019)

A human immunodeficiency virus negative, 71-year-old man who presented with a stridorous cough was found to have a focal tracheal stenosis associated with regional lymphadenopathy on chest computed tomography. On direct inspection, tracheal lesions were noted and biopsied with a 2.4 mm cryoprobe, establishing the diagnosis of primary tracheal lymphoma. The patient subsequently received chemotherapy, with clinical and imaging improvement of the tracheal stenosis. This case highlights a very rare cause for tracheal lesions and the use of cryoprobe over forceps biopsy as a tool to facilitate optimal tissue acquisition and diagnosis.
Polymerization of aniline by copper‐catalyzed air oxidation (2006)

Abstract A novel method for preparing organosoluble and conducting polyaniline (PANI) is presented. It is demonstrated that Cu(II) is an excellent catalyst for the polymerization of aniline by air oxygen in aqueous emulsions. Reactions carried out at 0 °C or at room temperature yield PANIs of reasonably high molecular weights (number‐average molecular weight = 23,000–114,000 Da) in an emeraldine base form that are soluble in many organic solvents, such as tetrahydrofuran, dimethylformamide, N ‐methylpyrrolidinone, chloroform, and acetone. Spectroscopic investigations (ultraviolet, Fourier transform infrared, and 1 H NMR) have shown that PANI obtained by this procedure has the same structure as those prepared by the conventional persulfate oxidation method. The resulting PANIs show reasonable electronic conductivities (0.067–0.320 S cm −1 ) upon doping with p ‐toluenesulfonic acid or dodecyl benzene sulfonic acid. © 2006 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 44: 6025–6031, 2006
Session details: Dance, dust, and drama: designing design (2010)

No abstract available.
Mannose-Binding Lectin Binds to Amyloid Protein and Modulates Inflammation (2012)

Mannose-binding lectin (MBL), a soluble factor of the innate immune system, is a pattern recognition molecule with a number of known ligands, including viruses, bacteria, and molecules from abnormal self tissues. In addition to its role in immunity, MBL also functions in the maintenance of tissue homeostasis. We present evidence here that MBL binds to amyloid β peptides. MBL binding to other known carbohydrate ligands is calcium-dependent and has been attributed to the carbohydrate-recognition domain, a common feature of other C-type lectins. In contrast, we find that the features of MBL binding to Aβ are more similar to the reported binding characteristics of the cysteine-rich domain of the unrelated mannose receptor and therefore may involve the MBL cysteine-rich domain. Differences in MBL ligand binding may contribute to modulation of inflammatory response and may correlate with the function of MBL in processes such as coagulation and tissue homeostasis.
Expression of X-linked retinoschisis protein RS1 in photoreceptor and bipolar cells (2001)

RS1 is expressed and assembled in photoreceptors of the outer retina and bipolar cells of the inner retina as a disulfide-linked oligomeric protein complex. The secreted complex associates with the surface of these cells, where it may function as a cell adhesion protein to maintain the integrity of the central and peripheral retina.
Towards a quantitative evaluation of multi-imaging systems (2017)

Nowadays many cameras embed multi-imaging (MI) technology without always giving the option to the user to explicitly activate or deactivate it. MI means that they capture multiple images, combine them and give a single final image, letting sometimes this procedure being completely transparent to the user. One of the reasons why this technology has become very popular is that natural scenes may have a dynamic range that is larger than the dynamic range of a camera sensor. So as to produce an image without under- or over-exposed areas, several input images are captured and later merged into a single high dynamic range (HDR) result. There is an obvious need for evaluating this new technology. In order to do so, we will present laboratory setups conceived so as to exhibit the characteristics and artifacts that are peculiar to MI, and will propose metrics so as to progress toward an objective quantitative evaluation of those systems. On the first part of this paper we will focus on HDR and more precisely on contrast, texture and color aspects. Secondly, we will focus on artifacts that are directly related to moving objects or moving camera during a multi-exposure acquisition. We will propose an approach to measure ghosting artifacts without accessing individual source images as input, as most of the MI devices most often do not provide them. Thirdly, we will expose an open question arising from MI technology about how the different smartphone makers define the exposure time of the single reconstructed image and will describe our work around a timemeasurement solution. The last part of our study concerns the analysis of the degree of correlation between the objective results computed using the proposed laboratory setup and subjective results on real natural scenes captured using HDR ON and OFF modes of a given device.
Advances in 3D neuronal microphysiological systems: towards a functional nervous system on a chip (2021)

Abstract Microphysiological systems (MPS) designed to study the complexities of the peripheral and central nervous systems have made marked improvements over the years and have allowed researchers to assess in two and three dimensions the functional interconnectivity of neuronal tissues. The recent generation of brain organoids has further propelled the field into the nascent recapitulation of structural, functional, and effective connectivities which are found within the native human nervous system. Herein, we will review advances in culture methodologies, focused especially on those of human tissues, which seek to bridge the gap from 2D cultures to hierarchical and defined 3D MPS with the end goal of developing a robust nervous system-on-a-chip platform. These advances have far-reaching implications within basic science, pharmaceutical development, and translational medicine disciplines.
Bobcat-1: The Ohio University CubeSat for Inter-Constellation Time Offset Determination (2019)

The determination of Global Navigation Satellite Systems (GNSS) inter-constellation time offset is still an open issue, and it would be particularly useful for those users with limited sky visibility. The increasing number of operative GNSS satellites is enabling more opportunities even for in-space users; users in the GNSS Space Service Volume (SSV) can exploit a PVT solution for orbit determination. However, it must be considered that users in the high SSV (GEO and HEO orbit) have a limited visibility of GNSS satellites. Even if four satellites in view are sufficient to determine a PVT solution when using a single GNSS constellation, when multiple constellations are involved it must be considered that an unknown is added for every different constellation considered, to estimate the time offset between constellations. As a result, when only one satellite is available from a constellation, there is no improvement in the positioning performance. This limitation could be overcome if the time offset among GNSS constellations would be provided to GEO users by an external source. The solution of the problem related to inter-constellation time offset is still on-going, and different approaches are under evaluation, implying a ground- network of GNSS receivers. The estimate exploiting in-space measurements from a CubeSat is an innovative technology to be explored. Bobcat-1, the Ohio University CubeSat, will be a “stepping-stone” to a Master clock in space. Bobcat-1 has been selected to be launched through the NASA CubeSat Launch Initiative and is scheduled to be in space by the end of 2020. Even if the mission’s primary objective will be the GNSS inter-constellation offset estimate, Bobcat-1 will also enable scientific studies, such as for example ionosphere TEC measurements applying a gradient algorithm. The focus of this paper is on the mission planning description, describing the analysis of the advantages that GEO satellites will get if provided with GNSS inter-constellation time offset estimates.
Supplementary Figure S4 from pVHL/HIF-Regulated CD70 Expression Is Associated with Infiltration of CD27<sup>+</sup> Lymphocytes and Increased Serum Levels of Soluble CD27 in Clear Cell Renal Cell Carcinoma (2023)

&lt;p&gt;A) Concentrations of sCD27 in supernatants of 786-O cocultured with different numbers of PBMCs determined by ELISA. B) Western blot of CD70 in 786-O and C) A498 treated with siRNA targeting CD70 (siCD70#1-4) or treated with siRNA control (siScr).&lt;/p&gt;