gebhart/patrepeval huggingface dataset:
Removal of Non-Steroidal Anti-Inflammatory Drugs from Drinking Water Sources by GO-SWCNT Buckypapers (2022)

Pharmaceutical products such as antibiotics, analgesics, steroids, and non-steroidal anti-inflammatory drugs (NSAIDs) are new emerging pollutants, often present in wastewater, potentially able to contaminate drinking water resources. Adsorption is considered the cheapest and most effective technique for the removal of pollutants from water, and, recently, membranes obtained by wet filtration method of SWCNT aqueous solutions (SWCNT buckypapers, SWCNT BPs) have been proposed as self-standing porous adsorbents. In this paper, the ability of graphene oxide/single-walled carbon nanotube composite membranes (GO-SWCNT BPs) to remove some important NSAIDs, namely Diclofenac, Ketoprofen, and Naproxen, was investigated at different pH conditions (pH 4, 6, and 8), graphene oxide amount (0, 20, 40, 60, and 75 wt.%), and initial NSAIDs concentration (1, 10, and 50 ppm). For the same experimental conditions, the adsorption capacities were found to strongly depend on the graphene oxide content. The best results were obtained for 75 wt.% graphene oxide with an adsorption capacity of 118 ± 2 mg g<sup>-1</sup> for Diclofenac, 116 ± 2 mg g<sup>-1</sup> for Ketoprofen, and 126 ± 3 mg g<sup>-1</sup> for Naproxen at pH 4. Overall, the reported data suggest that GO-SWCNT BPs can represent a promising tool for a cheap and fast removal of NSAIDs from drinking water resources, with easy recovery and reusability features.
Origin of Endogenous DNA Abasic Sites in Saccharomyces cerevisiae (2003)

Abasic (AP) sites are among the most frequent endogenous lesions in DNA and present a strong block to replication. In Saccharomyces cerevisiae, an apn1 apn2 rad1 triple mutant is inviable because of its incapacity to repair AP sites and related 3'-blocked single-strand breaks (M. Guillet and S. Boiteux, EMBO J. 21:2833, 2002). Here, we investigated the origin of endogenous AP sites in yeast. Our results show that the deletion of the UNG1 gene encoding the uracil DNA glycosylase suppresses the lethality of the apn1 apn2 rad1 mutant. In contrast, inactivation of the MAG1, OGG1, or NTG1 and NTG2 genes encoding DNA glycosylases involved in the repair of alkylation or oxidation damages does not suppress lethality. Although viable, the apn1 apn2 rad1 ung1 mutant presents growth delay due to a G(2)/M checkpoint. These results point to uracil as a critical source of the formation of endogenous AP sites in DNA. Uracil can arise in DNA by cytosine deamination or by the incorporation of dUMP during replication. Here, we show that the overexpression of the DUT1 gene encoding the dUTP pyrophosphatase (Dut1) suppresses the lethality of the apn1 apn2 rad1 mutant. Therefore, this result points to the dUTP pool as an important source of the formation of endogenous AP sites in eukaryotes.
A Configurable Cloud-Scale DNN Processor for Real-Time AI (2018)

Interactive AI-powered services require low-latency evaluation of deep neural network (DNN) models-aka ""real-time AI"". The growing demand for computationally expensive, state-of-the-art DNNs, coupled with diminishing performance gains of general-purpose architectures, has fueled an explosion of specialized Neural Processing Units (NPUs). NPUs for interactive services should satisfy two requirements: (1) execution of DNN models with low latency, high throughput, and high efficiency, and (2) flexibility to accommodate evolving state-of-the-art models (e.g., RNNs, CNNs, MLPs) without costly silicon updates. This paper describes the NPU architecture for Project Brainwave, a production-scale system for real-time AI. The Brainwave NPU achieves more than an order of magnitude improvement in latency and throughput over state-of-the-art GPUs on large RNNs at a batch size of 1. The NPU attains this performance using a single-threaded SIMD ISA paired with a distributed microarchitecture capable of dispatching over 7M operations from a single instruction. The spatially distributed microarchitecture, scaled up to 96,000 multiply-accumulate units, is supported by hierarchical instruction decoders and schedulers coupled with thousands of independently addressable high-bandwidth on-chip memories, and can transparently exploit many levels of fine-grain SIMD parallelism. When targeting an FPGA, microarchitectural parameters such as native datapaths and numerical precision can be "synthesis specialized" to models at compile time, enabling atypically high FPGA performance competitive with hardened NPUs. When running on an Intel Stratix 10 280 FPGA, the Brainwave NPU achieves performance ranging from ten to over thirty-five teraflops, with no batching, on large, memory-intensive RNNs.
Dietary N-Carbamylglutamate Supplementation Boosts Intestinal Mucosal Immunity in Escherichia coli Challenged Piglets (2013)

N-carbamylglutamate (NCG) has been shown to enhance performance in neonatal piglets. However, few studies have demonstrated the effect of NCG on the intestinal mucosal barrier. This study was conducted to determine the effects of dietary NCG supplementation on intestinal mucosal immunity in neonatal piglets after an Escherichia coli (E. coli) challenge. New-born piglets (4 d old) were assigned randomly to one of four treatments (n = 7), including (I) sham challenge, (II) sham challenge +50 mg/kg NCG, (III) E. coli challenge, and (IV) E. coli challenge +50 mg/kg NCG. On d 8, pigs in the E. coli challenge groups (III and IV) were orally challenged with 5 mL of E. coli K88 (10(8) CFU/mL), whereas pigs in the sham challenge groups (I and II) were orally dosed with an equal volume of water. On d 13, all piglets were sacrificed, and samples were collected and examined. The results show that average daily gain in the E. coli challenged piglets (III and IV) was decreased (PE.coli<0.05). However, it tended to be higher in the NCG treated piglets (II and IV). Ileum secretory IgA, as well as IFN-γ, IL-2, IL-4 and IL-10 in ileal homogenates, were increased in E. coli challenged piglets (III and IV). Similarly, ileum SIgA and IL-10 levels, and CD4(+) percentage in NCG treated piglets (II and IV) were higher than no-NCG treated piglets (PNCG<0.05). However, the IL-2 level was only decreased in the piglets of E. coli challenge + NCG group (IV) compared with E. coli challenge group (III) (P<0.05). No change in the IL-2 level of the sham challenged piglets (III) was observed. In conclusion, dietary NCG supplementation has some beneficial effects on intestinal mucosal immunity in E. coli challenged piglets, which might be associated with stimulated lymphocyte proliferation and cytokine synthesis. Our findings have an important implication that NCG may be used to reduce diarrhea in neonatal piglets.
Near-ideal reverse leakage current and practical maximum electric field in β-Ga2O3 Schottky barrier diodes (2020)

We investigate the intrinsic reverse leakage mechanisms in Ni-based Schottky barrier diodes (SBDs) fabricated on a (2¯01) single crystal β-Ga2O3 substrate, where a uniform bulk reverse leakage current has been designed and confirmed. The temperature-dependent reverse leakage characteristics are analyzed by a numerical reverse leakage model, which includes both the image-force lowering and doping effects. We found that the reverse leakage current is near-ideal and dominated by Schottky barrier tunneling throughout the entire range of the surface electric field from 0.8 MV/cm to 3.4 MV/cm. The extracted barrier height from the reverse leakage model is consistent with the values extracted from the forward current–voltage and capacitance–voltage measurements. The practical maximum electric field, defined by the maximum allowable reverse leakage current levels, is calculated as a function of the barrier height. These results suggest that it is possible to approach the intrinsic breakdown electric field in β-Ga2O3 SBDs, as long as a sufficiently high barrier height (∼2.2 to 3 eV) is employed.
[Schoolchild nutrition in the Lithuanian SSR]. (1978)

The nutrition of schoolchildren was studied on the ground of questionnaires, physiological characteristics of the schoolchildrens' organism, by considering their protein and vitamin C allowances and also by the nourishment status of children, these being classified according to groups of physical development adopted in the USSR.
DETECCION DE ANTICUERPOS ANTI-Leishmania (Trypanosomatidae) EN POBLACIONES CANINAS DEL DEPARTAMENTO DE SUCRE, COLOMBIA (2015)

&lt;p class="p1"&gt;&lt;strong&gt;RESUMEN&lt;/strong&gt;&lt;/p&gt;&lt;p class="p2"&gt;El objetivo de la investigación fue determinar la prevalencia de anticuerpos anti-Leishmania en perros del departamento de Sucre, Colombia. Se analizaron 122 perros del área rural de los municipios de Ovejas, Sampués y Sincelejo, mediante la técnica de inmunofluorescencia indirecta (IFI). Anticuerpos anti-Leishmania fueron detectados en el 69,6 % (IC95 % = 61,1 – 78,2) de la población canina estudiada. En el municipio de Sincelejo la seropositividad fue del 72 % (IC95 % = 61,1 – 82,8), en el municipio de Sampués del 68,4 % (IC95 % = 52,3 – 84,5) y en el municipio de Ovejas del 55,5 % (IC95 % = 21,2 – 86,3). Los animales seropositivos fueron principalmente caninos jóvenes y adultos. El 17,6 % de los perros seropositivos mostró signos clínicos compatibles con leishmaniasis canina, entre los cuales la onicogrifosis, alopecia y caquexia fueron los más comunes. La alta frecuencia de caninos con anticuerpos a Leishmania detectada en el presente estudio, pone de manifiesto la hiperendemicidad de la leishmaniasis canina en esta zona del país, así como el alto riesgo de brotes epidémicos de la enfermedad.&lt;/p&gt;&lt;p class="p1"&gt;&lt;strong&gt;ABSTRACT&lt;/strong&gt;&lt;/p&gt;&lt;p class="p2"&gt;The aim of this survey was to determine prevalence of antibodies against Leishmania in dogs from Sucre, Colombia. We analyzed 122 dogs in rural areas from municipalities of Sampués, Ovejas and Sincelejo, by indirect immunofluorescence (IFA). Anti-Leishmania antibodies were detected in 69.6 % (95 % CI = 61.1 to 78.2) of the selected canine population. In the municipality of Sincelejo, Sampues and Ovejas, the seropositivities were 72 % (95 % CI = 61.1 to 82.8), 68.4 % (95 % CI = 52.3 to 84.5) and 55.5 % (95 % CI = 21.2 to 86.3) respectively. Seropositive animals were mainly young and adult dogs. The 17.6 % of seropositive dogs showed clinical signs compatible with canine leishmaniasis; onychogryphosis, alopecia and cachexia were the most common ones. The detected high frequency of canines with antibodies against Leishmania in the present study, highlights the hyperendemicity status of canine leishmaniasis in this area of the country and the high risk of disease outbreaks.&lt;/p&gt;
Hemorrhagic shock primes for IL-1β processing: role of upregulated TLR2 (136.1) (2010)

Abstract IL-1β contributes to post-trauma sepsis, and its release requires processing in inflammasomes. Hemorrhagic shock (HS) primes for IL-1β release in response to LPS via yet unclear mechanisms. We have reported that HS-activated neutrophils (PMN) augment LPS/TLR4 signaling upregulation of TLR2 in alveolar macrophages (AM), thereby sensitizing the AM to TLR2 ligands. Here, we addressed the role of upregulated TLR2 in the HS-primed IL-1β processing. WT, TLR4-mutant and TLR2 KO mice were subjected to HS, followed by intratracheal LPS (30 µg/kg B.W.) and PGN (30 µg/kg B.W.) at 2h and 4h after HS, respectively. Bronchoalveolar lavage fluids (BALF) were collected at 2 h after PGN for detection of IL-1β. In vitro, AM were co-cultured with PMN isolated from HS mice, and treated with LPS, PMN was then removed and PGN was added at 2h. IL-1β and caspase-1 maturation in the AM were assessed. In vivo treatments of LPS and PGN caused a marked increase in IL-1β in BALF in the WT/HS mice, but not in the WT/sham, TLR4-mutant/HS or TLR2 KO/HS mice. HS-activated PMN increased TLR2 expression in AM in response to LPS, and subsequently increased caspase-1 and IL-1β maturation in the AM as well as IL-1β release in response to PGN. Moreover increasing extracellular [K+] failed to prevent the TLR2 signal-induced IL-1β maturation. In HS, amplified TLR2 signaling acts as a second signal in stimulating caspase-1 and IL-1β maturation via mechanisms independent of K+ efflux.
Experimental evaluation of a liquid desiccant air conditioning system for tri-generation/waste-heat-driven applications (2016)

This paper aims to evaluate the application of liquid desiccant air conditioning technology in the development of efficient and effective tri-generation/waste-heat-driven system applications, in particular with regard to solid oxide fuel cell (SOFC) technology. Using operational thermal input values typical of an SOFC combined heat and power (CHP) system, the paper's evaluation validates the concept of integrating SOFC and liquid desiccant air conditioning technology into an efficient and effective first-of-its-kind tri-generation system. This is due to good dehumidification capacity and effective regeneration of a potassium formate solution at a 0.65-0.7 solution mass concentration. Conclusions of the paper's evaluation include: (1) effective instantaneous balancing of the dehumidifier and regenerator across a range of environmental and operational values, (2) operation of the dehumidifier is dictated, to some degree by the available thermal energy (CHP prime mover, process heat), (3) encouraging thermal COP values, for a system of this scale, in the range of 0.4-0.66 are achievable with a low-grade thermal input (45-60C) typical of an SOFC CHP system and (4) potential for non-synchronous operation in a tri-generation system context, bringing about improvements to peak cooling output and total system efficiency. The compact nature and effective use of low-grade thermal energy means the liquid desiccant air conditioning system demonstrates significant potential for integration with other CHP prime mover technologies such as internal combustion engine or any (waste) heat source with a similar thermal quality/quantity. A future paper by the authors will present a novel SOFC liquid desiccant tri-generation system.
Data-driven 3D Voxel Patterns for object category recognition (2015)

Despite the great progress achieved in recognizing objects as 2D bounding boxes in images, it is still very challenging to detect occluded objects and estimate the 3D properties of multiple objects from a single image. In this paper, we propose a novel object representation, 3D Voxel Pattern (3DVP), that jointly encodes the key properties of objects including appearance, 3D shape, viewpoint, occlusion and truncation. We discover 3DVPs in a data-driven way, and train a bank of specialized detectors for a dictionary of 3DVPs. The 3DVP detectors are capable of detecting objects with specific visibility patterns and transferring the meta-data from the 3DVPs to the detected objects, such as 2D segmentation mask, 3D pose as well as occlusion or truncation boundaries. The transferred meta-data allows us to infer the occlusion relationship among objects, which in turn provides improved object recognition results. Experiments are conducted on the KITTI detection benchmark [17] and the outdoor-scene dataset [41]. We improve state-of-the-art results on car detection and pose estimation with notable margins (6% in difficult data of KITTI). We also verify the ability of our method in accurately segmenting objects from the background and localizing them in 3D.
Concentrations, Sources, and Fate of the Gasoline Oxygenate Methyl tert-Butyl Ether (MTBE) in a Multiple-Use Lake (1998)

Discovery of the fuel additive methyl tert-butyl ether (MTBE) in drinking water supplies is of concern to public health officials, water suppliers, and the public. Despite recent policy decisions, few published studies exist on the concentrations, sources, and fate of MTBE in surface waters. The purpose of this study was to determine (1) the relative contribution of motorized watercraft as a source of MTBE, (2) its seasonal distribution, (3) loss from the water column, (4) the extent of vertical transport, and (5) its persistence between years; this work was done in Donner Lake, California, a multiple-use lake in the Sierra Nevada Mountains. MTBE measurements were made at 9 individual depths from surface to bottom on 16 dates. Recreational boating was the most important source of MTBE. Statistically, 86% of the change in MTBE was explained by variation in motorized watercraft use. Neither highway runoff nor precipitation contributed significantly. MTBE concentration ranged from <0.1 μg·L-1 to a high of 12 μg·L-1. Between July 1 and 7, 1997, MTBE content rose dramatically from 115 to 365 kg. By January, levels had declined to a minimum of 15 kg, suggesting little interannual persistence. The major loss of MTBE appeared to be volatilization at the air−water interface characterized by two distinct periods. During the boating season, MTBE decline was 1.2 kg·day-1 (193 day half-life). At the end of the boating season, MTBE loss increased to 8.1 kg·day-1 (14 day half-life). Thermal stratification acted to retard MTBE transport to deeper depths.
Effect of Water Activity on Enterotoxin B Production and Growth of Staphylococcus aureus (1971)

Staphylococcus aureus C-243, an enterotoxin B-producing strain, was cultured on media adjusted to various water activity (a w ) levels by means of two different solute systems. Total numbers and rate of growth were diminished at low a w levels, and enterotoxin synthesis was extremely sensitive to reduction in a w . A reduction of a w from 0.99 to 0.98 in one medium and from 0.99 to 0.97 in the other medium resulted in extremely low levels of enterotoxin in spent culture media despite the attainment of high numbers of staphylococci.
Wavelength conversion from 1.3 µm to 1.5 µm using Raman-assisted three-wave mixing in a single-mode optical ﬁber (1999)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text T. Sylvestre, H. Maillotte, E. Lantz, P. T. Dinda, and A. B. Moubissi, "Wavelength conversion from 1.3 µm to 1.5 µm using Raman-assisted three-wave mixing in a single-mode optical fiber," in Nonlinear Guided Waves and Their Applications, OSA Technical Digest (Optica Publishing Group, 1999), paper ThD33. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Budesonide Enema in Distal Ulcerative Colitis: a Randomized Dose-Response Trial with Prednisolone Enema as Positive Control (1991)

The effect of budesonide, 1, 2, and 4 mg/100 ml in daily enemas, on active distal ulcerative colitis was compared with that of prednisolone disodium phosphate enemas, 25 mg/100 ml, in a multicentre, randomized, group-comparative trial. A total of 146 patients with active disease were treated for 2 weeks. Data from 139 were valid for statistical analyses. Bowel habits, proctoscopy findings, and histologic pictures were evaluated, and plasma cortisol was determined for measurement of influence on the hypothalamic-pituitary-adrenal axis. Clinical symptoms and proctoscopy findings improved within all treatment groups. The improvement of these effect variables tended to be less after treatment with the lowest dose of budesonide, 1 mg/100 ml, than after the other treatments. Plasma cortisol did not change in any of the budesonide groups, whereas a mean reduction of 30% (P = 0.07) was observed after prednisolone. It can be concluded that budesonide enemas of 2 mg/100 ml constitute an attractive alternative to prednisolone enemas for topical treatment of distal ulcerative colitis.
<title>Feature space analysis: effects of MRI protocols</title> (2000)

We present a method for exploring the relationship between the image segmentation results obtained by an optimal feature space method and the MRI protocols used. The steps of the work accomplished are as follows. (1) Three patients with brain tumors were imaged by a 1.5T General Electric Signa MRI System, using multiple protocols (T1- and T2-weighted spin- echo and FLAIR). T1-weighted images were acquired before and after Gadolinium (Gd) injection. (2) Image volumes were co- registered, and images of a slice through the center of the tumor were selected for processing. (3) Nine sets of images were defined by selecting certain MR images (e.g., 4T2's + 1T1, 4T2's + FLAIR, 2T2's + 1T1). (4) Using the images in each set, the optimal feature space was generated and images were segmented into normal tissues and different tumor zones. (5) Segmentation results obtained using different MRI sets were compared. We found that the locations of the clusters for the tumor zones and their corresponding regions in the image domain changed to some extent as a function of the MR images (MRI protocols) used. However, the segmentation results for the total lesion and normal tissues remained almost unchanged.
A New Species of Freshwater Eel-tailed Catfish of the Genus Tandanus (Teleostei: Plotosidae) from Coastal Rivers of Mid-northern New South Wales, Australia (2017)

Tandanus bellingerensis, new species, is described based on specimens from four river drainages (Bellinger, Macleay, Hastings, and Manning rivers) of the mid-northern coast of New South Wales, Australia. Previously, three species were recognized in the genus Tandanus: T. tropicanus of the wet tropics region of northeast Queensland, T. tandanus of the Murray-Darling drainage and coastal streams of central-southern Queensland and New South Wales, and T. bostocki of southwestern Western Australia. The new species is distinguished from all congeners by a combination of the following morphologic characters: a high count of rays in the continuous caudodorsal and anal fins (range 153–169, mode 159), a high count of gill rakers on the first arch (range 35–39, mode 36), and strongly recurved posterior serrae of the pectoral-fin spine. Additionally, results from previously conducted genetic studies corroborate morphologic and taxonomic distinctness of the new species.
서로 다른 강도의 제자리 벤취 스텝핑 훈련이 40대 중년 여성의 최대 운동시 혈청지질에 미치는 영향 (1997)

서로 다른 강도의 제자리 벤취 스텝핑 운동이 40대 중년 여성의 최대 운동시 혈청지질에 미치는 영향. 운동과학, 제6권 재1호. 13-22, 1977. 본 연구는 좌식생활을 주로 하는 중년 여성을 대상으로 운동 전, 4주후, 그리고 8주후 각 스텝 높이(15.3㎝, 20.3㎝, 25.4㎝)와 음악의 템포(0∼4주 : 115bpm, 5∼8주 : 120bpm, 9∼12주 : 125bpm)를 이용하여 운동부하 강도 프로그램을 설정하였다. 그리고 이 설정된 운동 프로그램에 의해 최대심박수의 90∼100%와 최대심박수의 80∼90% 강도로 제자리 벤취 스텝핑 훈련을 12주 동안 훈련을 실시하여 최대 운동후 혈청지질의 변화 양상을 규명함으로써 중년 여성들의 성인병 예방과 치료를 위한 운동유형의 방법으로 적용하고자 하는데 그 목적이 있다. TC에서 훈련 전·후 80∼90%, 집단은 유의한 변화가 없었으며, 90∼100% 집단은 유의한 증가(P<0.05)를 나타냈다. 집단 간 비교에서는 유의미한 차이가 없었다. TG에서 훈련 전·후 80∼90% 집단은 유의한 증가(P<0.01)를 나타냈으며, 90∼100% 집단은 유의한 변화를 나타내지 못했다. 집단 간 비교에서는 유의미한 차이가 없었다. HDL-C에서 운동 전·후 80∼90%와 90∼100% 집단은 유의한 증가(P<0.05)를 나타났다. 집단 간 비교에서는 유의한 차이가 없었다. LDL-C에서는 두 집단 모두 운동 전·후에 변화를 나타내지 못했으며, 집단간에서도 변화를 나타내지 못했다. 따라서 12주간의 제자리 벤취 스텝핑운동은 80∼90%와 90∼100%의 운동강도는 심폐지구력과 관련이 있는 HDL-C수준 농도에 있어서만 긍정적인 변화를 가져올 수 있으나 최대 운동시 다른 요인의 혈청지질의 변화 양상에는 효과적인 결과가 없었다. 그러므로 심혈관계와 관련이 있는 HDL-C수준 변화는 제자리 벤취 스텝핑 훈련을 통해 효과적인 양상을 보였기 때문에 심혈관계와 관련이 있는 제자리 스텝핑 훈련이 중년 여성들의 심혈관질환의 예방적인 운동의 유형으로 이용될 수 있다고 사료된다.
지역사회 중심의 일차의료의 활성화를 통한 만성질환관리 서비스디자인 연구 (2017)

현대 사회의 급속한 인구 고령화로 인해 우리나라 인구의 사망 및 질병의 구조가 만성질환 위주로 변화하고 있다. 만성질환은 고혈압, 당뇨 등 지속적인 관리와 꾸준한 생활습관 개선이 필요한 질환으로, 보건소 중심의 만성질환관리사업을 추진하여 교육 위주의 서비스를 제공하였으나, 이는 일부 파악된 환자에 국한되어 서비스가 전체적으로 확산되지 못하였고 의료기관에서의 진료와 보건소의 교육이 연결되지 못하여 효과적인 만성질환자의 건강관리가 어려운 실정이다. 따라서 본 연구는 만성질환자의 지속적인 관리를 위하여 1차 의료기관의 서비스를 통해 지역사회 건강서비스와 연계된 수요자 중심의 자기주도형 만성질환 건강관리 서비스모델 개발을 목표로 하였다. 서비스디자인 더블다이아몬드 프로세스를 기반으로 지역사회 중심의 의료서비스 경험을 측정하기 위하여 데스크리서치 및 관찰‧인터뷰를 기반으로 한 현실적인 조사 방법을 통해 서비스 수요자‧공급자의 이용패턴 및 잠재적 니즈를 파악하고, 의료서비스디자인을 위한 서비스의 맥락(Contextual)을 분석하여 만성질환 건강관리 서비스 모델을 개발하였다. 이는 지역사회와 연계된 일차의료 중심의 만성질환 건강관리 서비스모델로, 동네 의원과 연결하는 건강센터를 구축하여 교육과 진료를 연계하여 하나의 확장된 서비스를 제공하고, 지속적으로 만성질환자의 꾸준한 관리를 기대할 수 있다.