gebhart/patrepeval huggingface dataset:
Lung Abscess During the Treatment of Relapsed Churg-Strauss Syndrome (2014)

ì ìë¤ì ì¤ë ê¸°ê° ê´í´ ìíë¥¼ ì ì§íë ì¤ ì¬ë°í Chrug-Strauss ì¦íêµ° íììì ìí´ë¡í¬ì¤íë§ì´ë ë° ê²½êµ¬ì© ì¤í ë¡ì´ë ì¹ë£ ì¤ ë°ìí íëì 1ìë¥¼ ê²½ííìë¤. ë³¸ ì¦ë¡ë ì¥ê¸°ê°ì ê´í´ íìë Churg-Strauss ì¦íêµ°ì´ ì¬ë°í ì ìê³ ì¹ë£ ì¤ ê°ì¼ì´ ë°ìíìì ë íí¬ìì¶©íë ´ì´ë ê±°ëì¸í¬ ë°ì´ë¬ì¤ ê°ì¼ê³¼ ê°ì ê¸°íê°ì¼ ì´ì¸ì ì¸ê· ê°ì¼ë ë°ìí ì ììì ë³´ì¬ì£¼ë ì¦ë¡ì´ê¸°ì ë¬¸íê³ ì°°ê³¼ í¨ê» ë³´ê³ íë ë°ì´ë¤. ì¤ì¬ ë¨ì´: Churg-Strauss ì¦íêµ°; íëì
Novel Interactions of Adiponectin with the Endocrine System and Inflammatory Parameters (2003)

Several markers of chronic immune activation have been found in association with obesity and insulin resistance. We aimed to study the interaction of adiponectin with chronic inflammation and known components of the insulin resistance syndrome. Insulin sensitivity (minimal model analysis) and plasma soluble fractions of TNF-alpha receptor 1 (sTNFR1) and 2 (sTNFR2), adrenal and thyroid function, and adiponectin were evaluated in 68 apparently healthy subjects. An additional group of type 2 diabetic patients (n = 19) similarly studied, except for insulin sensitivity, were also included in the analysis. As reported by others, serum adiponectin concentrations were higher in women than in men (13.55 +/- 9.79 vs. 8.64 +/- 7.83 mg/liter; P = 0.018). They were also higher in healthy subjects compared with diabetic patients (10.35 +/- 8.48 vs. 7.41 +/- 8.31 mg/liter; P = 0.021). As expected also, circulating adiponectin was significantly associated with waist to hip ratio (r = -0.28; P = 0.013), diastolic blood pressure (r = -0.25; P = 0.027), fasting plasma high-density lipoprotein cholesterol (r = 0.35; P = 0.001), triglycerides (r = -0.37; P = 0.001), and insulin sensitivity (r = 0.30; P = 0.011). Additionally, subjects in the higher quartile of circulating adiponectin had lower sTNFR2 concentrations (3.05 vs. 4.37 microg/liter; P = 0.012), a trend to lower sTNFR1 concentrations (1.76 vs. 2.20 microg/liter; P = 0.055), higher concentration of serum morning cortisol (16.86 vs. 13.52 microg/dl; P = 0.027), and higher serum free T(4) levels (1.31 vs. 1.20 ng/dl; P = 0.038). Multiple regression analysis models were constructed to predict adiponectin concentrations. Predictive variables in these models included insulin sensitivity, waist to hip ratio and free T(4), contributing to 17%, 10%, and 8% of adiponectin variance, respectively, These findings suggest that circulating adiponectin differentially modulates insulin action and that thyroid-axis, inflammatory cytokines, and the adrenal cortex might intervene in this modulation.
Long-term relaxation of the photovoltage in a heteroepitaxial structure (1997)

The distribution of the transverse photovoltage has been investigated in samples of a Ge-GaAs heterostructure with an oxide layer (∼15 Å) at the interface. A method of simultaneous excitation with modulated and unmodulated radiation is used to observe the long-term relaxation of the photovoltage in these heterostructures. The energy barriers responsible for this effect are localized at the surface of the Ge film and the GaAs substrate, adjacent to the interlying oxide. It is shown that the gradients of the dark carrier concentration in the film and in the substrate are in opposite directions. A transition layer is formed during the growth process and not as a result of the classical heterodiffusion of the components in the film and the substrate. It is noted that the photoconductivity signal observed at the modulation frequency in the field formed at the sample as a result of the unmmodulated illumination must be taken into account in the recorded voltage signal.
Resonance Raman spectroscopy of metallochlorins: models for green heme protein prosthetic groups (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTResonance Raman spectroscopy of metallochlorins: models for green heme protein prosthetic groupsLaura A. Andersson, Thomas M. Loehr, Chi K. Chang, and A. Grant MaukCite this: J. Am. Chem. Soc. 1985, 107, 1, 182–191Publication Date (Print):January 1, 1985Publication History Published online1 May 2002Published inissue 1 January 1985https://pubs.acs.org/doi/10.1021/ja00287a033https://doi.org/10.1021/ja00287a033research-articleACS PublicationsRequest reuse permissionsArticle Views128Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Panel (2018)

Recently, there has begun a movement towards Fairness, Accountability, and Transparency (FAT) in algorithmic decision making, and in data science more broadly. The database community has not been significantly involved in this movement, despite "owning" the models, languages, and systems that produce the (potentially biased) input to the machine learning applications. What role should the database community play in this movement? Do the objectives of fairness, accountability and transparency give rise to core data management issues that can drive new research questions and new systems, or are these "soft topics" that are best left to be managed with policy? Will emphasis on these topics dilute our core competency in techniques and technologies for data, or can it reinforce our central role in technology stacks ranging from startups to the enterprise, and from local non-profits to the federal government? The goal of this panel is to debate these questions, and to whet the appetite of the data management community for research in this important emerging area.
The 'stretched'-Golay and other codes for high-SNR finite-delay quantization of the Gaussian source at 1/2 bit per sample (1990)

Error-correcting codes are considered as codebooks for high-performance vector quantization (VQ) of the IID Gaussian source at fractional bit rate. A family of good rate-one-half codes is introduced: the stretched Golay codes. The performance of these codes is compared to other good block codes, trellis-coded quantization, and other techniques. The stretched Golay codes are shown to outperform previously published results for block lengths 32, 40, 56, and 64. The good performance, together with fast decoding make these techniques attractive for applications such as low-bit-rate coding of speech.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Electrical resistivity imaging of unknown bridge foundations (2013)

ABSTRACT Unknown bridge foundations pose a significant safety risk due to stream scour and erosion. Records from older structures may be non‐existent, incomplete or incorrect. We evaluate 2D and 3D electrical resistivity imaging (ERI) as a means to reliably identify the depth of unknown bridge foundations. A survey procedure is described for mixed terrain/water environments in the presence of rough terrain. Some electrodes are installed on the stream banks while others are adapted for underwater use. Tests were conducted at five field sites, including three roadway bridges, a geotechnical test site and a railway bridge, containing drilled shafts and spread footings of both known and unknown depth extent. The 2D data acquisition was carried out in the dipole‐dipole configuration. The 2D ERI method resolved the shape and depth extent of the larger bridge foundations but, with less accuracy, the shape and depth extent of the smaller foundations. The 3D ERI method is time‐consuming and does not add sufficient additional value over 2D ERI to become a practical tool for unknown bridge foundation investigations. The 2D ERI method is a cost‐effective geophysical method that is relatively easy to use by bridge engineers.
Suprathreshold stochastic resonance: large N encoding (2008)

This chapter discusses the behaviour of the mutual information and channel capacity in the suprathreshold stochastic resonance model as the number of threshold elements becomes large or approaches infinity. The results in Chapter 4 indicate that the mutual information and channel capacity might converge to simple expressions of N in the case of large N. The current chapter finds that accurate approximations do indeed exist in the large N limit. Using a relationship between mutual information and Fisher information, it is shown that capacity is achieved either (i) when the signal distribution is Jeffrey's prior, a distribution which is entirely dependent on the noise distribution, or (ii) when the noise distribution depends on the signal distribution via a cosine relationship. These results provide theoretical verification and justification for previous work in both computational neuroscience and electronics.
Effects of organic pollutants on oceanic photosynthetic function mediated by Prochlorococcus (2015)

Society of Environmental Toxicology and Chemistry (SETAC) Europe 25th Annual Meeting, 3-7 May 2015, Barcelona.-- 2 pages, 4 figures
The role of the LDL receptor in apolipoprotein B secretion (2000)

Familial hypercholesterolemia is caused by mutations in the LDL receptor gene (Ldlr). Elevated plasma LDL levels result from slower LDL catabolism and a paradoxical lipoprotein overproduction. We explored the relationship between the presence of the LDL receptor and lipoprotein secretion in hepatocytes from both wild-type and LDL receptor-deficient mice. Ldlr(-/-) hepatocytes secreted apoB100 at a 3.5-fold higher rate than did wild-type hepatocytes. ApoB mRNA abundance, initial apoB synthetic rate, and abundance of the microsomal triglyceride transfer protein 97-kDa subunit did not differ between wild-type and Ldlr(-/-) cells. Pulse-chase analysis and multicompartmental modeling revealed that in wild-type hepatocytes, approximately 55% of newly synthesized apoB100 was degraded. However, in Ldlr(-/-) cells, less than 20% of apoB was degraded. In wild-type hepatocytes, approximately equal amounts of LDL receptor-dependent apoB100 degradation occured via reuptake and presecretory mechanisms. Adenovirus-mediated overexpression of the LDL receptor in Ldlr(-/-) cells resulted in degradation of approximately 90% of newly synthesized apoB100. These studies show that the LDL receptor alters the proportion of apoB that escapes co- or post-translational presecretory degradation and mediates the reuptake of newly secreted apoB-containing lipoprotein particles.
An Efficient Copper-Catalyzed Etherification of Aryl Halides (2011)

An efficient and mild copper-catalyzed ether formation from aryl halides and aliphatic alcohols has been developed. The key to the successful coupling is the use of lithium alkoxide, directly or in situ generated by lithium tert-butoxide, and the corresponding alcohol as solvent.
A Novel Comprehensive Network Security Assessment Approach (2011)

Network security assessment is critical to the survivability and reliability of distributed systems. In this paper, we propose a novel assessment approach that supports automatic vulnerability assessment utilizing Bayesian attack graphs. We also integrate several major vulnerability database into a comprehensive database and build a customized vulnerability scanner to assist attack graph generation. Different from existing solutions that manually assign probabilities to a Bayesian attack graph, we design a set of quantitative metrics to automatically analyze vulnerability and evaluate the proposed approach with real-world examples. Our results show the promising capability of the proposed approach in further improving assessment quality.
Sparse-matrix canonical grid (SMCG) method for dense medium scattering (2003)

In this paper, the sparse matrix canonical grid (SMCG) method is applied to study electromagnetic scattering from a dense medium. This dense medium may either be randomly distributed two-dimensional infinite dielectric cylinders or three-dimensional dielectric particles. For arbitrarily shaped 2D or 3D dielectric scatterers, it is more convenient to adopt a volumetric integral equation formulation with the scatterers divided into squares or cubes of a uniform size so that free-space Green's functions can be used. Instead of using the addition theorem for the indirect far-interaction calculations, we employ the Taylor series expansion, the same procedure as adopted in the SMCG method applied to rough surface scattering.
Improvement of human tumor cloning assay by suspension of fibroblasts into the bottom layer of agarose (1986)

Twenty-nine human tumors were cultured on a soft agarose cloning assay under three conditions: (1) standard (control); (2) standard with varying numbers of mitomycin C-treated 3T3 Swiss mouse embryonic fibroblasts suspended into the bottom layer of agarose; and (3) standard with varying concentrations of conditioned medium derived from those same fibroblasts. Suspension of 1 X 10(5) fibroblasts into the bottom layer of agarose was found to significantly increase the number of colonies formed over control specimens, as did cultures with 30% conditioned medium. In addition, compared with control, both of these techniques increased the number of specimens which would allow optimal vitro chemotherapy sensitivity testing. Specifically, growth of at least 30 colonies per plate increased from 7% of specimens treated under control conditions to 36% and 52% of specimens treated with 30% conditioned medium and 1 X 10(5) fibroblast-supplemented agar, respectively. This data indicate that 3T3 Swiss mouse fibroblasts improve cloning efficiency when suspended in the bottom layer of agarose or when used to produce conditioned medium. As a consequence, these techniques may permit a better opportunity to define the role of the cloning assay for cancer chemotherapy.
Regional Radiation Therapy Impacts Outcome for Node-Positive Cutaneous Melanoma (2017)

<b>Background:</b> Regional radiation therapy (RT) has been shown to reduce the risk of regional recurrence with node-positive cutaneous melanoma. However, risk factors for regional recurrence, especially in the era of sentinel lymph node biopsy (SLNB), are less clear. Our goals were to identify risk factors associated with regional recurrence and to determine whether a radiosensitivity index (RSI) gene expression signature (GES) could identify patients who experience a survival benefit with regional RT. <b>Methods:</b> A single-institution, Institutional Review Board-approved study was performed including 410 patients treated with either SLNB with or without completion lymph node dissection (LND; n=270) or therapeutic LND (n=91). Postoperative regional RT was delivered to the involved nodal basin in 83 cases (20.2%), to a median dose of 54 Gy (range, 30-60 Gy) in 27 fractions (range, 5-30). Primary outcomes were regional control and overall survival by RSI GES status. <b>Results:</b> Median follow-up was 69 months (range, 13-180). Postoperative regional RT was associated with a reduced risk of regional recurrence among all patients on univariate (5-year estimate: 95.0% vs 83.3%; <i>P</i>=.036) and multivariate analysis (hazard ratio[HR], 0.15; 95% CI, 0.05-0.43; <i>P</i><.001). Among higher-risk subgroups, regional RT was associated with a lower risk of regional recurrence among patients with clinically detected lymph nodes (n=175; 5-year regional control: 94.1% vs 69.5%; <i>P</i>=.003) and extracapsular extension (ECE) present (n=138; 5-year regional control: 96.7% vs 62.2%; <i>P</i><.001). Among a subset of radiated patients with gene expression data available, a low RSI GES (radiosensitive) tumor status was associated with improved survival compared with a high RSI GES (5-year: 75% vs 0%; HR, 10.68; 95% CI, 1.24-92.14). <b>Conclusions:</b> Regional RT was associated with a reduced risk of regional recurrence among patients with ECE and clinically detected nodal disease. Gene expression data show promise for better predicting radiocurable patients in the future. In the era of increasingly effective systemic therapies, the value of improved regional control potentially takes on greater significance.
Optimal predictive control of thermal storage in hollow core ventilated slab systems (1997)

A Doctoral Thesis. Submitted in partial fulfilment of the requirements for the award of Doctor of Philosophy of Loughborough University
Laryngeal muscle biology in thePink1−/−rat model of Parkinson disease (2019)

Neuromuscular pathology is found in the larynx and pharynx in humans with Parkinson disease (PD); however, it is unknown when this pathology emerges. We hypothesized that pathology occurs in early (premanifest) stages. To address this, we used the <i>Pink1-/-</i> rat model of PD, which shows age-dependent dopaminergic neuron loss, locomotor deficits, and deficits related to laryngeal function. We report findings in the thyroarytenoid muscle (TA) in <i>Pink1-/-</i> rats compared with wild-type (WT) control rats at 4 and 6 mo of age. TAs were analyzed for force production, myosin heavy chain isoform (MyHC), centrally nucleated myofibers, neural cell adhesion molecule, myofiber size, and muscle section size. Compared with WT, <i>Pink1-/-</i> TA had reductions in force levels at 1-Hz stimulation and 20-Hz stimulation, increases in relative levels of MyHC 2L, increases in incidence of centrally nucleated myofibers in the external division of the TA, and reductions in myofiber size of the vocalis division of the TA at 6 mo of age. Alterations of laryngeal muscle biology occur in a rat model of premanifest PD. Although these alterations are statistically significant, their functional significance remains to be determined. <b>NEW & NOTEWORTHY</b> Pathology of peripheral nerves and muscle has been reported in the larynx and pharynx of humans diagnosed with Parkinson disease (PD); however, it is unknown whether differences of laryngeal muscle occur at premanifest stages. This study examined the thyroarytenoid muscles of the <i>Pink1-/-</i> rat model of PD for differences of muscle biology compared with control rats. Thyroarytenoid muscles of <i>Pink1-/-</i> rats at premanifest stages show differences in multiple measures of muscle biology.
Transesophageal echocardiography in the trauma patient (1997)

Expeditious and accurate diagnosis in the trauma patient is crucial for survival. Appropriate interventions (medical and surgical) are required, using highly skilled personnel in a trauma center. Transesophageal echocardiography is one of many diagnostic devices that should be available in this process. Experience and knowledge from the cardiac and cardiothoracic sectors benefitted its use in the critical care and the emergency center environments. Studies in the critical care areas have revealed its worth. Some investigations, using transesophageal echocardiography in the acute trauma setting, are noticeably changing our approach to and appreciation of the complications of the acutely traumatized patient.
High dynamic range video distribution using existing video codecs (2013)

High Dynamic Range (HDR) is a strong candidate for the next video format, closer to the human perception for an increased user experience. However, the HDR video compression field is still under much investigation. Most of the time, HDR video codecs are based on already existing distribution-dedicated LDR video codecs, for instance H.264/AVC or H.265/HEVC. Some coding methods use two instances of a LDR codec: one for the LDR layer and one for the HDR residual layer. Other methods encode HDR frames directly using a high profile professional codec with a bit-depth well beyond the standard 8 bits. In this paper, we present a technique that requires only one instance of an 8-bit distribution codec. Our technique transforms HDR frames into LDR-like ones and uses metadatas to help the decoder to achieve a good HDR reconstruction. Results show that our solution performs well for bit-rate targeted in broadcast video content.
Tumor-Targeting Peptide Conjugated pH-Responsive Micelles as a Potential Drug Carrier for Cancer Therapy (2010)

Herein, we prepared tumor-targeting peptide (AP peptide; CRKRLDRN) conjugated pH-responsive polymeric micelles (pH-PMs) in cancer therapy by active and pH-responsive tumor targeting delivery systems, simultaneously. The active tumor targeting and tumoral pH-responsive polymeric micelles were prepared by mixing AP peptide conjugated PEG-poly(d,l-lactic acid) block copolymer (AP-PEG-PLA) into the pH-responsive micelles of methyl ether poly(ethylene glycol) (MPEG)-poly(beta-amino ester) (PAE) block copolymer (MPEG-PAE). These mixed amphiphilic block copolymers were self-assembled to form stable AP peptide-conjugated and pH-responsive AP-PEG-PLA/MPEG-PAE micelles (AP-pH-PMs) with an average size of 150 nm. The AP-pH-PMs containing 10 wt % of AP-PEG-PLA showed a sharp pH-dependent micellization/demicellization transition at the tumoral acid pH. Also, they presented the pH-dependent drug release profile at the acidic pH of 6.4. The fluorescence dye, TRITC, encapsulated AP-pH-PMs (TRITC-AP-pH-PMs) presented the higher tumor-specific targeting ability in vitro cancer cell culture system and in vivo tumor-bearing mice, compared to control pH-responsive micelles of MPEG-PAE. For the cancer therapy, the anticancer drug, doxorubicin (DOX), was efficiently encapsulated into the AP-pH-PMs (DOX-AP-pH-PMs) with a higher loading efficiency. DOX-AP-pH-PMs efficiently deliver anticancer drugs in MDA-MB231 human breast tumor-bearing mice, resulted in excellent anticancer therapeutic efficacy, compared to free DOX and DOX encapsulated MEG-PAE micelles, indicating the excellent tumor targeting ability of AP-pH-PMs. Therefore, these tumor-targeting peptide-conjugated and pH-responsive polymeric micelles have great potential application in cancer therapy.
Ready formation of water-stable PtII-(μ-NH2)-PdII species through combination of trans-[(NH3)2PtIIL2] (L = N,N′-heterocycle) and [enPd(H2O)2]2+ (2000)

Mixed-metal (PtII, PdII) μ-NH2-complexes are readily formed upon reaction of trans-[(NH3)2PtL2] (L = 2-aminopyridine-N1 or pyrazolate-N1; charges omitted) with [enPd(H2O)2]2+.
Increased interleukin-1 beta in the crevicular fluid of diseased implants. (1996)

Diseased implants can be distinguished from healthy implants by the presence of inflammation in the surrounding tissue. Inflammation correlates with elevated levels of interleukin-1 beta in gingival crevicular fluid. An analysis of interleukin-1 beta levels in diseased implants compared to those in matching healthy implants in 12 patients indicates that the level of interleukin-1 beta was approximately three times that at healthy sites. Interleukin-1 beta levels may provide a means of monitoring the health status of dental implants.
Supplementary Figure from Cabozantinib Enhances Anti-PD1 Activity and Elicits a Neutrophil-Based Immune Response in Hepatocellular Carcinoma (2023)

Supplementary Figure from Cabozantinib Enhances Anti-PD1 Activity and Elicits a Neutrophil-Based Immune Response in Hepatocellular Carcinoma