gebhart/patrepeval huggingface dataset:
Metal Complexes and Metals in Macromolecules:  Synthesis, Structures and Properties By Dieter Wöhrle (University of Bremen) and Anatoli D. Pomogailo (Russian Academy of Sciences, Chernogolovka). Wiley-VCH:  Weinheim. 2003. xviii + 667 pp. $215.00. ISBN 3-527-30499-1. (2003)

ADVERTISEMENT RETURN TO ISSUEPREVBook ReviewNEXTMetal Complexes and Metals in Macromolecules: Synthesis, Structures and Properties By Dieter Wöhrle (University of Bremen) and Anatoli D. Pomogailo (Russian Academy of Sciences, Chernogolovka). Wiley-VCH: Weinheim. 2003. xviii + 667 pp. $215.00. ISBN 3-527-30499-1.Randolph P. ThummelView Author Information University of HoustonCite this: J. Am. Chem. Soc. 2004, 126, 4, 1299–1300Publication Date (Web):December 19, 2003Publication History Published online19 December 2003Published inissue 1 February 2004https://pubs.acs.org/doi/10.1021/ja033593xhttps://doi.org/10.1021/ja033593xbook-reviewACS PublicationsCopyright © 2004 American Chemical SocietyRequest reuse permissionsArticle Views131Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Coordination polymers,Metals,Peptides and proteins,Polymer films,Sandwich compounds Get e-Alerts
Modeling Polymer Flooding with Crossflow in Layered Reservoirs Considering Viscous Fingering (2017)

Abstract Polymer flooding has been commercially applied to a number of viscous oil fields in the past decade and gradually gained more popularity. Due to limited injectivity in viscous-oil reservoirs, a relatively low polymer viscosity is usually used to avoid excessive injection pressure. In such a case, mobility ratio of polymer solution to oil is much greater than one, which implies unstable flow and strong viscous fingering. Existing reservoir simulators lack the capability of modeling such a physical phenomenon. Since many viscous-oil reservoirs have high permeability contrast between layers, we are motivated to study, for the first time, the impact of crossflow between different layers considering the presence of viscous fingering. Numerical modeling polymer floods with crossflow in a layered viscous-oil reservoir is difficult due to two major challenges: first is how to correctly allocate flow rates from the wellbore to multiple layers; and second is how to capture the viscous fingering effect without using excessively fine grids. To address the first issue, we developed an implicit well-rate-allocation model based on the potential method, which fully couples all the wellbore segments of each well with reservoir gridblocks to ensure a physical wellbore pressure. To deal with the second challenge, we implemented the effective fingering model, which is an upscaling model that lumps all the viscous fingers in a coarse grid block into one fictitious finger to allow for accurate estimation of fingering strength and growth during unstable flows. Both models were validated individually against the analytical solution or experimental data. The integrative module including the two new capabilities was used to simulate a polymer flood following a waterflood in a layer-cake reservoir in North America with moderate oil viscosity. We observed the fast propagation of water fronts and small fingering fraction in high permeability layers during the waterflooding phase, indicating active channeling and viscous fingering. The subsequent polymer flooding minimized both factors of oil bypassing and led to stable flow and high sweep efficiency. Without the implicit well-rate-allocation model, crossflow was overestimated and wellbore pressures of different well blocks were not consistent. Without the effective-fingering model, oil recovery was overestimated due to the lack of accounting for viscous fingering. The simulation results indicated that polymer flooding improved both displacement and sweep efficiencies. The model has shown comprehensive capabilities in reservoir simulations of polymer floods including unstable floods and crossflows between layers. This is a major significance to optimization of non-thermal viscous-oil EOR projects and also making more informed operational decisions for field developments.
Tandem Mass Spectrometry of Ribonuclease A and B:  N-Linked Glycosylation Site Analysis of Whole Protein Ions (2001)

Recently, an approach for the "top down" sequence analysis of whole protein ions has been developed, employing electrospray ionization, collision-induced dissociation, and ion/ion proton-transfer reactions in a quadrupole ion trap mass spectrometer. This approach has now been extended to an analysis of the [M + 12H]12+ to [M + 5H]5+ ions of ribonuclease A and its N-linked glycosylated analogue, ribonuclease B, to determine the influence of the posttranslational modification on protein fragmentation. In agreement with previous studies on the fragmentation of a range of protein ions, facile gas-phase fragmentation was observed to occur along the protein backbone at the C-terminal of aspartic acid residues, and at the N-terminal of proline, depending on the precursor ion charge state. Interestingly, no evidence was found for gas-phase deglycosylation of the N-linked sugar in ribonuclease B, presumably due to effective competition from the facile amide bond cleavage channels that "protect" the N-linked glycosidic bond from cleavage. Thus, localization of the posttranslational modification site may be determined by analysis of the "protein fragment ion mass fingerprint".
Supplementary Table S1 from High-level Coexpression of JAG1 and NOTCH1 Is Observed in Human Breast Cancer and Is Associated with Poor Overall Survival (2023)

Supplementary Table S1 from High-level Coexpression of JAG1 and NOTCH1 Is Observed in Human Breast Cancer and Is Associated with Poor Overall Survival
Intrahepatic amebic abscesses: indications for and results of percutaneous catheter drainage. (1985)

Medical therapy is standard for intrahepatic amebic abscess and generally is effective. However, we have encountered a group of patients in whom percutaneous aspiration and drainage was indicated due to uncertainty of diagnosis or clinical deterioration of the patient. Twenty such patients underwent percutaneous drainage with ultrasound or CT guidance, and each patient was cured (appropriate antibiotics were administered concomitantly). The specific indications for intervention were to differentiate pyogenic from amebic abscess, pain and imminent rupture, poor response to medical therapy, false-negative results of serologic tests, noncompliance with medical treatment, left lobe abscess, and pregnancy. Diagnosis of amebiasis from examination of the fluid was seldom possible, while findings from core biopsy of the wall of the abscess led to diagnosis in three cases. Recurrence necessitating redrainage occurred in three patients; in each, catheters were removed the same day drainage was performed. There were three minor complications. Differences from percutaneous management of pyogenic abscesses included more rapid removal of catheters (four days), more frequent use of US guidance, and more common use of the prone angled approach to avoid pleural contamination. Catheter drainage may be curative and may expedite care for problematic amebic liver abscesses in selected cases.
Cassava Production Enterprise in the Tropics (2022)

Cassava, a tropical root crop, provides the staple food for millions of people around the world. It is one of the tuber crops that could be cultivated on a small scale in an environment with erratic rainfall, and without necessarily needing heavy equipment and machineries. Cassava could be successfully cultivated by resource-poor farm family. Farmers’ productivity could be as much as 70 tonnes per hectares under favourable conditions. However, smallholder farmers do among other things improve productivity through proven cultural practices and a mix of organic and inorganic measures. Irrigation is very necessary for achieving bumper harvest in areas with shortage of rainfall and insufficient soil moisture content. The concept of sustainability in the practice of agriculture has been on the front burner world over in recent time. Therefore, the cultivation of cassava with the aim of increased productivity without jeopardising the factors of production meant for future time is encouraged. Practices that combine traditional knowledge with modern technologies that are adapted to the needs of small-scale farmers are on the increase around the world. Depending on the purpose, cassava could be harvested anytime from eight month. Cassava leaves could serve as vegetable and the stems use as fire wood.
Automated Network Analysis Identifies Core Pathways in Glioblastoma (2010)

We confirm and extend the observation that GBM alterations tend to occur within specific functional modules, in spite of considerable patient-to-patient variation, and that two of the largest modules involve signaling via p53, Rb, PI3K and receptor protein kinases. We also identify new candidate drivers in GBM, including AGAP2/CENTG1, a putative oncogene and an activator of the PI3K pathway; and, three additional significantly altered modules, including one involved in microtubule organization. To facilitate the application of our network-based approach to additional cancer types, we make the method freely available as part of a software tool called NetBox.
SiRNA‐targeted carboxypeptidase D inhibits hepatocellular carcinoma growth (2013)

Carboxypeptidase D (CPD), a membrane-bound metallocarboxypeptidase that functions as a docking receptor for duck hepatitis B virus, is frequently overexpressed in human cancers. We have explored its expression pattern, clinical significance, and biological function of CPD in hepatocellular carcinoma (HCC). CPD expression was markedly elevated in HCCs relative to adjacent non-tumor liver tissues, as determined by quantitative real-time polymerase chain reaction and Western blot analysis. Immunohistochemistry showed that 164 of 400 (41%) HCCs had high expression of CPD. CPD overexpression was significantly associated with serum levels of hepatitis B surface antigen and hepatitis B e antigen, liver cirrhosis, pathological grade, and intrahepatic metastasis. Knockdown of endogenous CPD expression in Huh7 HCC cells by RNA interference reduced cell proliferation, blocked the cell cycle at G1 phase, and increased apoptosis. Many genes implicated in cell-cycle regulation, including P21waf1, P27 Kip1, SKP2, and CDC2, were deregulated by CPD downregulation. Thus CPD is frequently upregulated in HCC, and targeting CPD inhibits HCC cell proliferation through induction of G1 cell-cycle arrest and apoptosis, thereby providing a potential therapeutic target for this malignancy.
Key interplay between the co-opted sorting nexin-BAR proteins and PI3P phosphoinositide in the formation of the tombusvirus replicase (2020)

Positive-strand RNA viruses replicate in host cells by forming large viral replication organelles, which harbor numerous membrane-bound viral replicase complexes (VRCs). In spite of its essential role in viral replication, the biogenesis of the VRCs is not fully understood. The authors identified critical roles of cellular membrane-shaping proteins and PI(3)P (phosphatidylinositol 3-phosphate) phosphoinositide, a minor lipid with key functions in endosomal vesicle trafficking and autophagosome biogenesis, in VRC formation for tomato bushy stunt virus (TBSV). The authors show that TBSV co-opts the endosomal SNX-BAR (sorting nexin with Bin/Amphiphysin/Rvs- BAR domain) proteins, which bind to PI(3)P and have membrane-reshaping function during retromer tubular vesicle formation, directly into the VRCs to boost progeny viral RNA synthesis. We find that the viral replication protein-guided recruitment and pro-viral function of the SNX-BAR proteins depends on enrichment of PI(3)P at the site of viral replication. Depletion of SNX-BAR proteins or PI(3)P renders the viral double-stranded (ds)RNA replication intermediate RNAi-sensitive within the VRCs in the surrogate host yeast and in planta and ribonuclease-sensitive in cell-free replicase reconstitution assays in yeast cell extracts or giant unilamellar vesicles (GUVs). Based on our results, we propose that PI(3)P and the co-opted SNX-BAR proteins are coordinately exploited by tombusviruses to promote VRC formation and to play structural roles and stabilize the VRCs during viral replication. Altogether, the interplay between the co-opted SNX-BAR membrane-shaping proteins, PI(3)P and the viral replication proteins leads to stable VRCs, which provide the essential protection of the viral RNAs against the host antiviral responses.
Clarifying Search (1997)

Current user interfaces for textual database searching leave much to be desired: individually, they are often confusing, and as a group, they are seriously inconsistent. We propose a four- phase framework for user-interface design: the framework provides common structure and terminology for searching while preserving the distinct features of individual collections and search mechanisms. Users will benefit from faster learning, increased comprehension, and better control, leading to more effective searches and higher satisfaction.
Experiments in Sensor Sharpening for Color Constancy (1998)

Sensor sharpening has been proposed as a method for improving color constancy algorithms but it has not been tested in the context of real color constancy algorithms. In this paper we test sensor sharpening as a method for improving color constancy algorithms in the case of three different cameras, the human cone sensitivity estimates, and the XYZ response curves. We find that when the sensors are already relatively sharp, sensor sharpening does not offer much improvement and can have a detrimental effect. However, when the sensors are less sharp, sharpening can have a substantive positive effect. The degree of improvement is heavily dependent on the particular color constancy algorithm. Thus we conclude that using sensor sharpening for improving color constancy can offer a significant benefit, but its use needs to be evaluated with respect to both the sensors and the algorithm.
NASVAC: una vacuna terapéutica con potencialidades para mejorar la calidad de vida del paciente con hepatitis B crónica (2011)

The Hepatitis B Virus (HBV) is a widely spread virus. According to the World Health Organization (WHO) more than one third of the world population has been infected with the Hepatitis B Virus. As a result, 350 to 400 million individuals are chronically infected -defined as persons with positive serology to HBsAg for more than 6 months. However, the prevalence of chronic hepatitis B (CHB) is higher in the southeast of Asia, sub-Saharan Africa and the Amazonia [1]. As you can easily realize, this is a problem starting in the viral infectivity and ending in the economic arena with a little bit of everything. The infection usually occurs early in life in countries with high prevalence as the virus can be transmitted from mother to child. In addition, parenteral and sexual routes of transmission are also very efficient. The long-term sustained HBV chronic infection leads to a progressive hepatic disease that could result in the development of more severe complications like liver cirrhosis and/or cancer in approximately 25% of carriers. In the last decade it was considered that more than one million HBV related deaths were produced worldwide due to the different forms of progression of this viral infection [2]. Current picture is not very different as the progression of the disease depends on the pool of already infected patients and the current treatments have several limitations. The treatment with alpha interferon (IFN-α), its polyethylenglycol-conjugated variant (PEG-IFN) and nucleos(t)ide analogs such as Lamivudine, Adefovir-dipivoxil, Entecavir, Tenofovir and Telbivudine. These drugs/treatments have a poor efficacy in terms of sustained virus clearance (from 7 to 20% of patients according to patients’ characteristics) and they produce important side effects [3]. The situation in poor countries is really dramatic as the inefficacy of drugs is linked to the high cost of treatments and to inadequate diagnostic and patient follow-up. The development of the anti-HBV vaccine, efficient to prevent HBV infection in a large percentage of cases, represents one of the most important medical achievements of the last century. At the present time more than 150 countries offer the anti-hepatitis B vaccine through immunization programs to children, adolescents and high risk groups. The next five years will show a reduction in the incidence of new infections, mostly in children. However, according to the current situation and the characteristics of the viral infection and treatments, the CHB will remain as a serious health problem for a long time.
Glutamate Triggers Rapid Glucose Transport Stimulation in Astrocytes as Evidenced by Real-Time Confocal Microscopy (2003)

Glutamate stimulates glycolysis in astrocytes, a phenomenon that couples astrocytic metabolism with neuronal activity. However, it is not known whether glutamate also affects glucose transporter-1 (GLUT1), the transporter responsible for glucose entry into astrocytes. To address this question, two different real-time single-cell hexose uptake assays were applied to cultured hippocampal astrocytes using confocal epifluorescence microscopy. Glutamate caused a twofold to threefold increase in the zero-trans uptake rates of the fluorescent hexoses 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxyglucose (2-NBDG) and 6-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-6-deoxyglucose (6-NBDG). Galactose uptake, determined by the calcein volumetric assay, was stimulated to a similar extent, confirming the fluorescent hexose data, and also demonstrating that glutamate stimulation is a Vmax effect. Remarkably, glucose transport stimulation developed fully inside 10 sec, which is 100 times faster than acute stimulations of glucose transport in other cell types. Glutamate did not significantly affect the rate of 6-NBDG uptake by GLUT1-expressing epithelial Clone 9 cells, suggesting that an astrocyte-specific factor is required for transport stimulation. We conclude that glucose transport stimulation occurs early during astrocytic activation by glutamate, which provides a novel regulatory node to current models of brain energy metabolism. This mechanism should also be considered for the interpretation of functional imaging data based on hexoses.
The Medication Advisor Project: Preliminary Report (2002)

The Medication Advisor is the latest project of the Conversational Interaction and Spoken Dialogue research group at the University of Rochester. The goal of the project is an intelligent assistant that interacts with its users via conversational natural language, and provides them with information and advice regarding their prescription medications. Managing prescription drug regimens is a major problem, particularly for older people living at home who tend to have both complex medication schedules and, often, somewhat reduced faculties for keeping track of them. Patient compliance with prescribed regimens is notoriously low, leading to incorrect and sometimes harmful usage of both prescribed and over-the-counter medications. The Medication Advisor builds on our prior experience constructing conversational assistants in other domains. In addition to providing new challenges, the project allows us to validate previous efforts in areas such as portability. This brief report details our initial efforts and outlines our future direction.
Sushifest: El festival de la comida que está de moda (2017)

Projecte que consisteix a desenvolupar una proposta sobre la creacio d’un festival de sushi a Barcelona. Aquest festival es perfecte per a que les marques de la ciutat puguin promocionar-se al mateix temps que el seu public passi una bona estona envoltat d’aquest aliment que esta tan de moda. En aquest projecte es mostra tant el festival (les activitats que es faran en ell, els publics que hi participaran, la decoracio de la localitzacio, etc), com la comunicacio que es desenvolupara per a donar-lo a coneixer i aconseguir que hi participi el maxim de gent possible.
Weakly Supervised Classification of Vital Sign Alerts as Real or Artifact (2022)

A significant proportion of clinical physiologic monitoring alarms are false. This often leads to alarm fatigue in clinical personnel, inevitably compromising patient safety. To combat this issue, researchers have attempted to build Machine Learning (ML) models capable of accurately adjudicating Vital Sign (VS) alerts raised at the bedside of hemodynamically monitored patients as real or artifact. Previous studies have utilized supervised ML techniques that require substantial amounts of hand-labeled data. However, manually harvesting such data can be costly, time-consuming, and mundane, and is a key factor limiting the widespread adoption of ML in healthcare (HC). Instead, we explore the use of multiple, individually imperfect heuristics to automatically assign probabilistic labels to unlabeled training data using weak supervision. Our weakly supervised models perform competitively with traditional supervised techniques and require less involvement from domain experts, demonstrating their use as efficient and practical alternatives to supervised learning in HC applications of ML.
Seismic behaviour of thin/slender concrete walls with monolithic emulation base connections tested on shaking table (2008)

Two geometrically identical slender precast concrete walls with monolithic emulation base connections were constructed and tested under biaxial loading using two clover displacement control patterns on shaking table. Specimen 1 was constructed with 1.27% longitudinal reinforcement bars which exceeding the requirement in BS 8110 and NZ 3101 while Specimen 2 was 0.54% longitudinal reinforcement bars within the range specified in BS 8110 and NZ 3101. Both specimens were subjected to quasistatic bilateral loading which was supplied by hydraulic double actuator. In-plane and out-of-plane drifts were applied to both specimens using Lissajous functions. Specimen 1 was subjected to 0.5%, 1.0% and 1.5% drift within two cycles in each drift. This wall failed in lateral torsional buckling mechanism with ductility of 3. Specimen 2 was tested at 0.5%, 1.0%, 1.5% and 2.0% drift. This specimen started to crack at 0.5% and more cracks were observed at 1.0% drift. This wall failed by low cycle fatigue behaviour associated with compression failure at the bottom of the wall with ductility of 4. It can be concluded that even though the slenderness ratio (height/thickness) is limited to 30 but experimental result showed that slenderness ratio 60:1 is still stable under biaxial loading. Experimental results showed that an increase of longitudinal reinforcement did not attribute to better seismic performance of thin/slender precast wall panels.