gebhart/patrepeval huggingface dataset:
Endothelial cell phagocytosis of senescent neutrophils decreases procoagulant activity (2013)

Abundant senescent neutrophils traverse the vascular compartment and may contribute to pathologic conditions. For example, they become procoagulant when undergoing apoptosis and may contribute to thrombosis or inflammation. Our previous studies demonstrated a dominant clearance pathway in which the neutrophils can be phagocytosed by liver macrophages. The aim of this study was to explore an alternate pathway of neutrophil clearance by endothelial cells. Phagocytosis of the neutrophils by endothelial cells was performed using various experimental approaches includingflow cytometry, confocal microscopy and electron microscopy assays in vitro and in vivo. Procoagulant activity of cultured neutrophils was evaluated by coagulation time, factor Xase and prothrombinase assays. Lactadherin functioned as a novel probe for the detection of phosphatidylserine on apoptotic cells, an opsonin (bridge) between apoptotic cell and phagocyte for promoting phagocytosis, and an efficient anticoagulant for inhibition of factor Xase and thrombin formation. When cultured, purified human neutrophils spontaneously entered apoptosis and developed procoagulant activity that was directly related to the degree of phosphatidylserine exposure. Co-culture of aged neutrophils and endothelial cells resulted in phagocytosis of the neutrophils and prolonged coagulation time. Lactadherin diminished the procoagulant activity and increased the rate of neutrophil clearance. In vivo, neutrophils were sequestered by endothelial cells after blockade of Kupffer cells, a process that was dependent upon both phosphatidylserine exposure and P-selectin expression. Thus, the ability of endothelial cells to clear senescent neutrophils may limit the procoagulant and/or inflammatory impact of these cells.
Impact of radio resource control mechanisms on the performance of Internet applications (2002)

The future generations of wireless networks are being designed to provide various types of packet data services. Radio resource control (RRC) protocols should be designed to configure the radio bearer so that the radio system capacity is maximized, the mobile terminal's battery drain is minimized and users' traffic requirements are met. It is inevitable that the RRC protocol will affect the performance of the network transport protocols and, in return, the network transport protocols will limit the radio systems ability to schedule resources efficiently. In this paper we describe a genetic model of RRC protocol states, which represents various air interfaces. Using this model, we investigate how the parameters of RRC protocol states affect the radio system control overhead and performance of Web browsing applications.
Controversies in the use of insulin analogues (2011)

The introduction of insulin analogues has had a major impact in diabetes care. However, the benefit of some of these new insulins for the patient has yet to be demonstrated. Furthermore, research is needed to clarify whether insulin glargine is more strongly associated with cancer risk compared with other insulins.
RNA Polymerase Activity and Inhibition in Herpesvirus-Infected Cells (1974)

The activity of the DNA-dependent RNA polymerase (ribonucleotide tri-phosphate:RNA nucleotidyl transferase, EC 2.7.7.6) was present but not proportional to protein concentration in unfractionated extracts of KB cells infected with herpes simplex virus. Chromatography on DEAE-Sephadex demonstrated two peaks of enzyme activity in infected cell extracts that had properties indistinguishable from the enzymes present in uninfected cells and an inhibitor of RNA polymerase activity that was not retained by the DEAE-Sephadex. The inhibitor was not present in uninfected cell extracts and was not formed if protein synthesis was blocked with cyclohexamide at the time of infection. The inhibitor could be partially purified by CM-Sephadex chromatography; it preferentially inhibited the nucleolar enzyme (peak I) and acted by stopping chain elongation. It is probable that this inhibitor of RNA polymerase participates in the reduction of cellular RNA synthesis observed after herpesvirus infection.
Two-Dimensional Nanosheets and Layered Hybrids of MoS2 and WS2 through Exfoliation of Ammoniated MS2 (M = Mo,W) (2013)

Ammoniated MS2 (M = Mo,W) have been synthesized by reacting LixMS2 with a saturated solution of ammonium chloride. While, largely neutral NH3 is present in the interlayer of ammoniated MoS2, equal amounts of NH3 and NH4+ ions are present in the tungsten analog. The ammoniated MS2 exfoliate readily in a variety of polar solvents with exfoliation being best in water. Ammoniated WS2 forms a more stable colloidal dispersion compared to the Mo analog because the ammonium ions do not deintercalate easily from the layers even on exfoliation. The dispersions are comprised of large nanosheets of MS2 with lateral dimensions in the order of micrometers. The layers could be restacked from the colloidal dispersions by evaporating the solvent. While the colloidal dispersions of ammoniated MoS2 yield NH3-free MoS2 on restacking, the dispersions of ammoniated WS2 yield WS2 intercalated with NH4+ ions. Co-stacking of MoS2 and WS2 nanosheets from a mixture of both the colloidal dispersions results in MoS2–WS2 hybrids in which the MoS2 and WS2 nanosheets are randomly stacked. Photoluminescence measurements of MS2 nanosheets and MoS2–WS2 hybrids indicate phase stability and existence of direct bandgap.
Preferential Formulation of Second Generation Antipsychotic Asenapine as Inclusion Complex with Sulphobutylether-βCD (Captisol): In vitro and In vivo Evaluation (2017)

This study thus demonstrated that Captisol® inclusion complex is an effective strategy for solubility and bioavailability enhancement of asenapine.
Epidural opioid analgesia in infant rats II: responses to carrageenan and capsaicin (1999)

The aim of this study was to investigate the analgesic effects of epidural opioids upon persistent pain sensitivity in neonatal rat pups. Two models of persistent pain were used, subcutaneous injection of carrageenan, and topical application of capsaicin cream, both to the hind paw. The contribution of individual opioid receptor subtypes in the spinal cord to analgesia were tested at different developmental stages using epidural mu (morphine sulphate), delta (DPDPE) and kappa (U69593) opioid receptor agonists in neonatal rats aged P (postnatal day) 3, 10 and 21. Rat pups at all three ages displayed a reduction in mechanical (von Frey hair) threshold following carrageenan-induced inflammation of the hind paw that was evident at 3 h and was still present 5 h after application. This effect was greatest in magnitude at P21. This response was blocked by low doses of all three agonists at all ages, relative effectiveness varying with age. Comparison with potencies in acute tests (Marsh, D., Dickenson, A., Hatch, D. and Fitzgerald, M., Epidural opioid analgesia in infant rats I: mechanical and heat responses, Pain 82 (1999) 23-32) show that opioid potency is significantly greater in the presence of carrageenan inflammation at all ages. Topical capsaicin application to the hind paw produced a significant fall in withdrawal latencies to noxious heat. Generally, epidural opioid agonists did not block this C-fibre induced sensitization except at P3, when morphine and DPDPE did prevent the fall in threshold in a dose dependent manner. The results show that newborn rat pups are capable of displaying both allodynia and hyperalgesia following experimental inflammation that is blocked by epidural mu, delta and kappa opioids. The opioid potency is enhanced compared with antinociception in acute tests. This is not observed following capsaicin hyperalgesia and is therefore not a general consequence of C fibre induced increases in central excitability but relies upon mechanisms special to inflammatory pain.
The weight distribution of quasi-quadratic residue codes (2018)

We investigate a family of codes called quasi-quadratic residue (QQR) codes. We are interested in these codes mainly for two reasons: Firstly, they have close relations with hyperelliptic curves and Goppa's Conjecture, and serve as a strong tool in studying those objects. Secondly, they are very good codes. Computational results show they have large minimum distances when $p\equiv 3 \pmod 8$. Our studies focus on the weight distributions of these codes. We will prove a new discovery about their weight polynomials, i.e. they are divisible by $(x^2 + y^2)^{d-1}$, where $d$ is the corresponding minimum distance. We also show that the weight distributions of these codes are asymptotically normal. Based on the relation between QQR codes and hyperelliptic curves, we will also prove a result on the point distribution on hyperelliptic curves.
Multichannel holography for particle field tomography (1986)

This is another use, based on an earlier application, 1 of spatial multichannel holography. A particle field can be examined by measuring its parameters layer by layer when reconstructing its hologram. But the fact that, at the image plane of a certain layer, defocused images of particles of other layers also appear disturbs the measurement. Multichannel holography can reduce the disturbance by shortening the focusing depth of images. To demonstrate: a particle field is simulated by a stack of nine glass plates and on one surface of each plate many small ink spots are spattered randomly. The stack is illuminated by a laser beam scattered from a large piece of ground glass and an off-axis hologram is taken. Reconstructed images of layers from that hologram and from an ordinary one (particle field is illuminated by a point source during recording) are compared with each other and with their corresponding true distributions on the plates. We find the former show much less disturbance. The same conclusion is obtained when images of tilted cross sections are compared.
State-Dependent Energy Shifts of Rydberg Atoms in a Ponderomotive Optical Lattice (2010)

We demonstrate the state dependence of the ponderomotive energy shift of Rydberg atoms in an optical lattice using microwave spectroscopy. Unique to Rydberg atoms, this dependence results from a state-dependent aspect ratio between Rydberg-atom size and lattice period. A semiclassical simulation reproduces all features observed in the microwave spectra and indicates the presence of trapped Rydberg atoms.
Radio science from an optical communications signal (2013)

NASA is currently developing the capability to deploy deep space optical communications links. This creates the opportunity to utilize the optical link to obtain range, Doppler, and signal intensity estimates. These may, in turn, be used to complement or extend the capabilities of current radio science. In this paper we illustrate the achievable parameter estimation errors in estimating range, Doppler, and received signal intensity of a one-way non-coherent optical link. We provide a joint estimation algorithm with performance close to the Cram`er-Rao bound. We draw comparisons to range estimates based on a coherent radio frequency signal, illustrating that large gains in either precision or observation time are possible with an optical link.
Development of automatic driving system on rough road-realization of high reliable automatic driving system (2003)

Describes the vehicle experimental system on rough road using an automatic driving method with guidance cables. This system is composed of an automatic driving controller with high reliability to give 'human like operation' and traffic control equipment which direct several vehicles to avoid collisions. To confirm the durability and the reliability of the system, automatic driving tests were carried out on a test course for a long distance. The result verified that the system was useful for a vehicle durability driving test on rough road.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Mononuclear Fe(I) and Fe(II) Acetylene Adducts and Their Reductive Protonation to Terminal Fe(IV) and Fe(V) Carbynes (2019)

The activity of nitrogenase enzymes, which catalyze the conversion of atmospheric dinitrogen to bioavailable ammonia, is most commonly assayed by the reduction of acetylene gas to ethylene. Despite the practical importance of acetylene as a substrate, little is known concerning its binding or activation in the iron-rich active site. “Fischer–Tropsch” type coupling of non-native C1 substrates to higher-order C≥2 products is also known for nitrogenase, though potential metal–carbon multiply bonded intermediates remain underexplored. Here we report the activation of acetylene gas at a mononuclear tris(phosphino)silyl-iron center, (SiP3)Fe, to give Fe(I) and Fe(II) side-on adducts, including S = 1/2 FeI(η2-HCCH); the latter is characterized by pulse EPR spectroscopy and DFT calculations. Reductive protonation reactions with these compounds converge at stable examples of unusual, formally iron(IV) and iron(V) carbyne complexes, as in diamagnetic (SiP3)Fe≡CCH3 and the paramagnetic cation S = 1/2 [(SiP3)Fe≡CCH3]+. Both alkylcarbyne compounds possess short Fe–C triple bonds (approximately 1.7 Å) trans to the anchoring silane. Pulse EPR experiments, X-band ENDOR and HYSCORE, reveal delocalization of the iron-based spin onto the α-carbyne nucleus in carbon p-orbitals. Furthermore, isotropic coupling of the distal β-CH3 protons with iron indicates hyperconjugation with the spin/hole character on the Fe≡CCH3 unit. The electronic structures of (SiP3)Fe≡CCH3 and [(SiP3)Fe≡CCH3]+ are discussed in comparison to previously characterized, but heterosubstituted, iron carbynes, as well as a hypothetical nitride species, (SiP3)Fe≡N. Such comparisons are germane to the consideration of formally high-valent, multiply bonded Fe≡C and/or Fe≡N intermediates in synthetic or biological catalysis by iron.
Vector Zernike wavefront sensor on the Santa Cruz Extreme AO Lab (SEAL) testbed (2022)

We present a description of the lab setup and first measurements from the vector-Zernike wavefront sensor (WFS) on the Santa Cruz Extreme AO Lab (SEAL) testbed. A goal of SEAL is to test and compare high-contrast imaging techniques for large telescopes with segmented primary mirrors. We focus on being a daytime lab for the W. M. Keck Observatory, which has a Zernike WFS already installed. SEAL consists of three deformable mirrors (one segmented and a woofer/tweeter system) and five wavefront sensors (Shack-Hartmann, two Pyramid WFSs, FAST focal plane, and vector-Zernike). The vector-Zernike WFS simultaneously measures phase and amplitude aberrations and is well-suited for phasing segmented primary mirrors as well as general-purpose low-order wavefront sensing. The setup consists of a liquid-crystal mask placed in the focal plane to cause a ±π/2 phase offset on the core of the point spread function (PSF), which then interferes with the remaining PSF. The circularly polarized light is split into two intensity pupil images, which are used to reconstruct the wavefront phase and amplitude. We use the segmented deformable mirror, which simulates the Keck segmented primary mirror, to introduce piston errors and correct them using the vector-Zernike WFS.
ChemInform Abstract: Isomerization of trans‐1,2‐Epoxy‐cis,trans‐5,9‐cyclododecadiene, trans‐ 1,2‐Epoxy‐trans,trans‐5,9‐cyclododecadiene and trans‐ Epoxycyclododecane to the Corresponding Ketones in the Presence of Iodides and Bromides of Lithium and Magnesium. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Parainfluenza 3 Infection Blocks the Ability of a Beta Adrenergic Receptor Agonist to Inhibit Antigen-induced Contraction of Guinea Pig Isolated Airway Smooth Muscle (1981)

Guinea pigs, actively sensitized to ovalbumin, were inoculated by nasal insufflation with parainfluenza 3 or virus growth medium 4 d before performing in vitro pharmacological studies on tracheal and bronchial smooth muscle. In each airway segment, cumulative dose-response effects of ovalbumin were obtained in the absence and presence of a maximally effective concentration of a beta adrenergic receptor agonist, sulfonterol. Sulfonterol shifted the dose-response curve to the right and reduced the maximum smooth muscle contractile response to ovalbumin. Virus infection did not alter the dose-response effects of ovalbumin. However, the magnitude of the inhibitory effects of sulfonterol was smaller in segments taken from animals inoculated with virus. Blockade by virus infection of the inhibitory effect of sulfonterol was reversed when the concentrations of beta agonist were increased. Sulfonterol did not alter the dose-response effects of histamine at any of the concentrations that markedly antagonized the effects of ovalbumin. Virus infection did not alter the sensitivities to sulfonterol or papaverine in producing relaxation in either airway segment. The magnitude of relaxation produced by papaverine was significantly larger in bronchial rings taken from animals infected with virus for 4 d, but there was no alteration by virus of the dose-response effects of histamine or carbachol. In experiments measuring antigen-induced release of slow reacting substance of anaphylaxis and histamine from minced lung, virus infection did not alter the sensitivity or the maximum effects of ovalbumin. Also, the ability of sulfonterol to inhibit the release of slow reacting substance of anaphylaxis and histamine was not affected by virus infection.These results demonstrate that infection of guinea pigs with respiratory virus results in a selective blockade of the beta adrenergic-mediated inhibition of antigen-induced contraction of airway smooth muscle. The guinea pig may serve as a useful model in physiological studies of virus-induced asthma.
Generation and Utility of Tertiary α‐Aminoorganolithium Reagents. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Observations in Solid Polyethylenes by Carbon-13 Nuclear Magnetic Resonance with Magic Angle Sample Spinning (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTObservations in Solid Polyethylenes by Carbon-13 Nuclear Magnetic Resonance with Magic Angle Sample SpinningWilliam L. Earl and D. L. VanderHartCite this: Macromolecules 1979, 12, 4, 762–767Publication Date (Print):July 1, 1979Publication History Published online1 May 2002Published inissue 1 July 1979https://pubs.acs.org/doi/10.1021/ma60070a045https://doi.org/10.1021/ma60070a045research-articleACS PublicationsRequest reuse permissionsArticle Views502Altmetric-Citations324LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Development of Mucosal Vaccine Using Bacterial Function for Targeting Mucosal Tissues (2014)

Most pathogens invade body through the mucosal epithelium, which is a primary target to prevent the infectious diseases. Mucosal vaccine has been considered to be an effective strategy to establish immunosurveillance against pathogens by the induction of antigen-specific immune responses at both mucosal and systemic immune compartments. The development of antigen delivery system and mucosal adjuvants are required for the sufficient induction of protective immunity in the development of mucosal vaccine. In this review, we shed light on the recent advances in the development of antigen delivery system using microbial functions for mucosal vaccines.
Photochemistry of N-heterocycles. VI. Thermal and photodecarboxylation of pyridylacetic acids and photocleavage of some 2-substituted pyridines (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotochemistry of N-heterocycles. VI. Thermal and photodecarboxylation of pyridylacetic acids and photocleavage of some 2-substituted pyridinesFrank R. Stermitz and Wu-Hsiung HuangCite this: J. Am. Chem. Soc. 1970, 92, 5, 1446–1448Publication Date (Print):March 1, 1970Publication History Published online1 May 2002Published inissue 1 March 1970https://pubs.acs.org/doi/10.1021/ja00708a080https://doi.org/10.1021/ja00708a080research-articleACS PublicationsRequest reuse permissionsArticle Views110Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Sub-picosecond UV laser pulse filamentation in atmosphere (2002)

Summary form only. Several studies have shown recently that ultrashort infrared laser pulses propagating through atmosphere may create long plasma filaments. This effect may have important applications in laser-controlled discharges, long-range deposition of high laser intensities, and new LIDAR monitoring. Here we present an investigation of the nonlinear propagation of sub-picosecond UV laser pulses in air. We show, for the first time, that filamentation is possible with UV laser pulses as well.
Whole is Greater than Sum of Parts: Recognizing Scene Text Words (2013)

Recognizing text in images taken in the wild is a challenging problem that has received great attention in recent years. Previous methods addressed this problem by first detecting individual characters, and then forming them into words. Such approaches often suffer from weak character detections, due to large intra-class variations, even more so than characters from scanned documents. We take a different view of the problem and present a holistic word recognition framework. In this, we first represent the scene text image and synthetic images generated from lexicon words using gradient-based features. We then recognize the text in the image by matching the scene and synthetic image features with our novel weighted Dynamic Time Warping (wDTW) approach. We perform experimental analysis on challenging public datasets, such as Street View Text and ICDAR 2003. Our proposed method significantly outperforms our earlier work in Mishra et al. (CVPR 2012), as well as many other recent works, such as Novikova et al. (ECCV 2012), Wang et al. al.(ICPR 2012), Wang et al.(ICCV 2011).