gebhart/patrepeval huggingface dataset:
Multi-foci metalens for spin and orbital angular momentum interaction (2015)

The development of metasurface, capable of controlling wave-fronts through interfacial phase discontinuity, offers a fascinating methodology for designing two dimensional miniaturized optical devices. Owing to an additional advantage of the enhanced useful transmission via Bainet-inverted matasurface, we exploit them to demonstrate an intriguing concept of merging the phase-profiles of two distinct optical devices, a lens and a spiral phase plate, to realize an ultrathin nanostructured optical vortex lens. The proposed device can has multiple focal planes along the longitudinal direction; whereas the number of focal plans, corresponding topological charges and focal lengths can readily be tailored to meet any desired requirements. Meanwhile, the dual-polarity feature of the optical vertex metalens exhibits spin controlled real and virtual focal plans, while dispersionless aptitude of nanobars enables its working over the broadband. The concept unveils a novel way of employing metasurface, to engraft the phase profiles of multiple bulk devices, to achieve unique functionalities for promising applications in integrated photonics.
Modeling comprehensive chemical composition of weathered oil following a marine spill to predict ozone and potential secondary aerosol formation and constrain transport pathways (2015)

Abstract Releases of hydrocarbons from oil spills have large environmental impacts in both the ocean and atmosphere. Oil evaporation is not simply a mechanism of mass loss from the ocean, as it also causes production of atmospheric pollutants. Monitoring atmospheric emissions from oil spills must include a broad range of volatile organic compounds (VOC), including intermediate‐volatile and semivolatile compounds (IVOC, SVOC), which cause secondary organic aerosol (SOA) and ozone production. The Deepwater Horizon (DWH) disaster in the northern Gulf of Mexico during Spring/Summer of 2010 presented a unique opportunity to observe SOA production due to an oil spill. To better understand these observations, we conducted measurements and modeled oil evaporation utilizing unprecedented comprehensive composition measurements, achieved by gas chromatography with vacuum ultraviolet time of flight mass spectrometry (GC‐VUV‐HR‐ToFMS). All hydrocarbons with 10–30 carbons were classified by degree of branching, number of cyclic rings, aromaticity, and molecular weight; these hydrocarbons comprise ∼70% of total oil mass. Such detailed and comprehensive characterization of DWH oil allowed bottom‐up estimates of oil evaporation kinetics. We developed an evaporative model, using solely our composition measurements and thermodynamic data, that is in excellent agreement with published mass evaporation rates and our wind‐tunnel measurements. Using this model, we determine surface slick samples are composed of oil with a distribution of evaporative ages and identify and characterize probable subsurface transport of oil.
MALDI-imaging reveals thymosin beta-4 as an independent prognostic marker for colorectal cancer (2015)

DNA aneuploidy has been identified as a prognostic factor for epithelial malignancies. Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) is a powerful tool for direct analysis of multiple proteins in tissue sections while maintaining the cellular and molecular integrity. We compared diploid and aneuploid colon cancer tissues against normal mucosa of the colon by means of IMS. DNA image cytometry determined the ploidy status of tissue samples that were subsequently subjected to MALDI-IMS. After obtaining protein profiles through direct analysis of tissue sections, a discovery and independent validation set were used to predict ploidy status by applying proteomic classification algorithms [Supervised Neural Network (SNN) and Receiver Operating Characteristic (ROC)]. Five peaks (m/z 2,395 and 4,977 for diploid vs. aneuploid comparison as well as m/z 3,376, 6,663, and 8,581 for normal mucosa vs. carcinoma comparison) were significant in both SNN and ROC analysis. Among these, m/z 4,977 was identified as thymosin beta 4 (Tβ-4). Tβ-4 was subsequently validated in clinical samples using a tissue microarray to predict overall survival in colon cancer patients.
3D printed microfluidic circuitry via multijet-based additive manufacturing (2015)

The miniaturization of integrated fluidic processors affords extensive benefits for chemical and biological fields, yet traditional, monolithic methods of microfabrication present numerous obstacles for the scaling of fluidic operators. Recently, researchers have investigated the use of additive manufacturing or "three-dimensional (3D) printing" technologies - predominantly stereolithography - as a promising alternative for the construction of submillimeter-scale fluidic components. One challenge, however, is that current stereolithography methods lack the ability to simultaneously print sacrificial support materials, which limits the geometric versatility of such approaches. In this work, we investigate the use of multijet modelling (alternatively, polyjet printing) - a layer-by-layer, multi-material inkjetting process - for 3D printing geometrically complex, yet functionally advantageous fluidic components comprised of both static and dynamic physical elements. We examine a fundamental class of 3D printed microfluidic operators, including fluidic capacitors, fluidic diodes, and fluidic transistors. In addition, we evaluate the potential to advance on-chip automation of integrated fluidic systems via geometric modification of component parameters. Theoretical and experimental results for 3D fluidic capacitors demonstrated that transitioning from planar to non-planar diaphragm architectures improved component performance. Flow rectification experiments for 3D printed fluidic diodes revealed a diodicity of 80.6 ± 1.8. Geometry-based gain enhancement for 3D printed fluidic transistors yielded pressure gain of 3.01 ± 0.78. Consistent with additional additive manufacturing methodologies, the use of digitally-transferrable 3D models of fluidic components combined with commercially-available 3D printers could extend the fluidic routing capabilities presented here to researchers in fields beyond the core engineering community.
A Fermented Whole Grain Prevents Lipopolysaccharides‐Induced Dysfunction in Human Endothelial Progenitor Cells (2017)

Endogenous and exogenous signals derived by the gut microbiota such as lipopolysaccharides (LPS) orchestrate inflammatory responses contributing to development of the endothelial dysfunction associated with atherosclerosis in obesity, metabolic syndrome, and diabetes. Endothelial progenitor cells (EPCs), bone marrow derived stem cells, promote recovery of damaged endothelium playing a pivotal role in cardiovascular repair. Since healthy nutrition improves EPCs functions, we evaluated the effect of a fermented grain, Lisosan G (LG), on early EPCs exposed to LPS. The potential protective effect of LG against LPS-induced alterations was evaluated as cell viability, adhesiveness, ROS production, gene expression, and NF-kB signaling pathway activation. Our results showed that LPS treatment did not affect EPCs viability and adhesiveness but induced endothelial alterations via activation of NF-kB signaling. LG protects EPCs from inflammation as well as from LPS-induced oxidative and endoplasmic reticulum (ER) stress reducing ROS levels, downregulating proinflammatory and proapoptotic factors, and strengthening antioxidant defense. Moreover, LG pretreatment prevented NF-kB translocation from the cytoplasm into the nucleus caused by LPS exposure. In human EPCs, LPS increases ROS and upregulates proinflammatory tone, proapoptotic factors, and antioxidants. LG protects EPCs exposed to LPS reducing ROS, downregulating proinflammatory and proapoptotic factors, and strengthening antioxidant defenses possibly by inhibiting NF-<i>κ</i>B nuclear translocation.
Electrical switching and short-range order in As-Te glasses (1993)

The local structural order in chalcogenide network glasses is known to change markedly at two critical compositions, namely, the percolation and chemical thresholds. In the ${\mathrm{As}}_{\mathit{x}}$${\mathrm{Te}}_{100\mathrm{\ensuremath{-}}\mathit{x}}$ glassy system, both the thresholds coincide at the composition x=40 (40 at. % of arsenic). It is demonstrated that the electrical switching fields of As-Te glasses exhibit a distinct change at this composition.
Large electron capture-cross-section of the major nonradiative recombination centers in Mg-doped GaN epilayers grown on a GaN substrate (2018)

Complementary time-resolved photoluminescence and positron annihilation measurements were carried out at room temperature on Mg-doped p-type GaN homoepitaxial films for identifying the origin and estimating the electron capture-cross-section (σn) of the major nonradiative recombination centers (NRCs). To eliminate any influence by threading dislocations, free-standing GaN substrates were used. In Mg-doped p-type GaN, defect complexes composed of a Ga-vacancy (VGa) and multiple N-vacancies (VNs), namely, VGa(VN)2 [or even VGa(VN)3], are identified as the major intrinsic NRCs. Different from the case of 4H-SiC, atomic structures of intrinsic NRCs in p-type and n-type GaN are different: VGaVN divacancies are the major NRCs in n-type GaN. The σn value approximately the middle of 10−13 cm2 is obtained for VGa(VN)n, which is larger than the hole capture-cross-section (σp = 7 × 10−14 cm2) of VGaVN in n-type GaN. Combined with larger thermal velocity of an electron, minority carrier lifetime in Mg-doped GaN becomes much shorter than that of n-type GaN.
Asymmetric cleavage of 2,2′-pyridil to a picolinic acid anion radical coordinated to ruthenium(ii): splitting of water to hydrogen (2013)

The Ru(II)-H and water promoted asymmetric cleavage of 2,2'-pyridil to pyridine-2-carbaldehyde and unprecedented picolinic acid anion radical (PyCOOH(-)˙) complexes, which in solution produce H2 gas and diamagnetic picolinate complexes of ruthenium(II) in moderate yields, is reported.
Expression of Angiotensin II Receptor-1 in Human Articular Chondrocytes (2012)

Background. Besides its involvement in the cardiovascular system, the renin-angiotensin-aldosterone (RAS) system has also been suggested to play an important role in inflammation. To explore the role of this system in cartilage damage in arthritis, we investigated the expression of angiotensin II receptors in chondrocytes. Methods. Articular cartilage was obtained from patients with osteoarthritis, rheumatoid arthritis, and traumatic fractures who were undergoing arthroplasty. Chondrocytes were isolated and cultured in vitro with or without interleukin (IL-1). The expression of angiotensin II receptor types 1 (AT1R) and 2 (AT2R) mRNA by the chondrocytes was analyzed using reverse transcription-polymerase chain reaction (RT-PCR). AT1R expression in cartilage tissue was analyzed using immunohistochemistry. The effect of IL-1 on AT1R/AT2R expression in the chondrocytes was analyzed by quantitative PCR and flow cytometry. Results. Chondrocytes from all patient types expressed AT1R/AT2R mRNA, though considerable variation was found between samples. Immunohistochemical analysis confirmed AT1R expression at the protein level. Stimulation with IL-1 enhanced the expression of AT1R/AT2R mRNA in OA and RA chondrocytes. Conclusions. Human articular chondrocytes, at least partially, express angiotensin II receptors, and IL-1 stimulation induced AT1R/AT2R mRNA expression significantly.
Improving the Compliance of Transplantation Medicine Patients with an Integrated Mobile System (2012)

Progress in healthcare has brought cure for severe ailments and greatly improved the quality of life of many patients. At the same time, the complexity of treatments has increased: patients do not understand treatment plans or fail to timely take the intended dosage of drugs. The consequence is a lack of compliance. Patients not adhering to medication plans likely face severe health problems. To support the relationship with physicians and patients' compliance, we developed the mobile platform appmedi. It helps patients to manage, which drugs they have to take, and to document their compliance to medication plans. appmedi has been designed for transplantation medicine because strict adherence is vital to save patients' lives. We present the medical background and explain the design of our prototype. We also sketch a usage scenario and discuss appmedi. It could be extended to other treatment contexts and might be integrated into holistic patient-care solutions.
Compact polarization-based all-optical interconnection systems with growth capability (1998)

All-optical communication requires all-optical interconnections, thus leading to reliable, fast, and flexible modular communication means in future systems. Free-space approaches are advantageous since they fully use the two dimensions optics offer. A folded architecture based on a polarization code is proposed for dynamic optical interconnection. The suggested systems are compact and appropriate for both intracomputer and intercomputer communication. The modularity of the proposed architecture is presented, and a growth rule for the fully connected versions of the system is introduced. The proposed approach significantly reduces both the price of the interconnection systems and their complexity. Presented are 4 x 4 and 8 x 8 fully connected switches, a rearrangeable nonblocking 4 x 4 switch, and a crossbar architecture.
The [3 + 2]- and [5 + 2]-cycloadditions of the cyclohepta-2,4-dienyl cation (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe [3 + 2]- and [5 + 2]-cycloadditions of the cyclohepta-2,4-dienyl cationWerner Heilmann, Rainer Koschinsky, and Herbert MayrCite this: J. Org. Chem. 1987, 52, 10, 1989–1993Publication Date (Print):May 1, 1987Publication History Published online1 May 2002Published inissue 1 May 1987https://pubs.acs.org/doi/10.1021/jo00386a017https://doi.org/10.1021/jo00386a017research-articleACS PublicationsRequest reuse permissionsArticle Views103Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Analysis of the Weinbaum-Jiji Model of Blood Flow in the Canine Kidney Cortex for Self-Heated Thermistors (1994)

The Weinbaum-Jiji equation can be applied to situations where: 1) the vascular anatomy is know; 2) the blood velocities are known; 3) the effective modeling volume includes many vessels; and 4) the vessel equilibration length is small compared to the actual length of the vessel. These criteria are satisfied in the situation where steady-state heated thermistors are placed in the kidney cortex. In this paper, the Weinbaum-Jiji bioheat equation is used to analyze the steady state response of four different sized self-heated thermistors in the canine kidney. This heat transfer model is developed based on actual physical measurements of the vasculature of the canine kidney cortex. In this model, parallel-structured interlobular arterioles and venules with a 60 microns diameter play the dominant role in the heat transfer due to blood flow. Continuous power is applied to the thermistor, and the instrument measures the resulting steady state temperature rise. If an accurate thermal model is available, perfusion can be calculated from these steady-state measurements. The finite element simulations correlate well in shape and amplitude with experimental results in the canine kidney. In addition, this paper shows that the Weinbaum-Jiji equation can not be used to model the transient response of the thermistor because the modeling volume does not include enough vessels and the vessel equilibration length is not small compared to the actual length of the vessel.
Large-Volume Liposuction and Extensive Abdominoplasty: A Feasible Alternative for Improving Body Shape (1998)

Forty-two female patients underwent liposuction of large volumes and extensive abdominoplasty during an 18-month period, with an average follow-up period of 9 months. Fifty-two percent of the patients underwent a third surgical procedure, which was basically aesthetic. The average age was 40 years; weight varied between 51 kg and 113 kg, with only 11 percent of the patients at their ideal weight. The tumescent technique was used for performing liposuction, which was done on the loins, trochanters, lumbar, upper scapular, and upper lateral abdominal regions, avoiding liposuction of the abdominal flap in all cases except for one. The abdominoplasty was extensive with detachment to the xiphoid process without detaching liposuctioned areas. Volumes of 1600 ml to 11,200 ml were obtained through liposuction, with an average of 4230 cc, and minimal blood loss. Fatty dermal tissue was removed through abdominoplasty and it varied between 400 g and 5000 g with an average of 1300 g. Only the two heaviest patients required an autologous blood unit, because they underwent breast reduction at the same time. All the other patients were managed exclusively with intravenous crystalloids solutions. No major complications arose, and only five patients had minor complications. Based on these results, we consider it to be feasible to combine the liposuctioning of large volumes with abdominoplasty to improve body shape, even with the addition of a third surgical procedure. Nevertheless, it is essential to use the tumescent technique for liposuction to reduce bleeding to a minimum and to allow us to perform other procedures.
Clinical Classification of Periodontitis in Adolescents and Young Adults (1997)

THE AIM OF THIS STUDY was to determine the degree to which clinical classifications based on cross-sectional assessments endure in the course of development of early-onset periodontitis (EOP), and to introduce new criteria which might improve the clinical classification of these diseases. Subjects with EOP and a matched group without EOP were identified within a national probability sample examined during the 1986/87 survey of US schoolchildren. Of these, 265 subjects (mean age 16 years) were re-examined during the 1992/93 school year. The clinical attachment level of teeth was assessed, and the individuals were classified into localized juvenile periodontitis (LJP), generalized juvenile periodontitis (GJP), incidental attachment loss (IAL), and no-periodontitis groups using three classification methods previously described. A fourth method that considered the extent and severity of attachment loss and the number of missing teeth was introduced to classify the individuals at baseline and at follow-up as having localized, generalized, or incidental EOP, and no-periodontitis groups. Furthermore, the individuals were classified using criteria based on the rate and pattern of change in attachment loss during 6 years. The results showed low correlations between the baseline classifications and the classifications at the 6-year follow-up examination, irrespective of the method used. In addition, the cross-sectional classifications were not predictive of the rate of progression of periodontal disease in these subjects. In the generalized disease group, two-thirds of the individuals exhibited moderate/rapid disease progression, while one-third had slow or no progression. In the localized disease group, one-half of the individuals had moderate/rapid disease progression and one-half had slow or no progression. In the incidental disease group one-fourth of the individuals had moderate/rapid disease progression and three-fourths had slow or no progression. We propose that the term early-onset periodontitis be used as a generic term to describe periodontal disease before its normal onset. In addition, we suggest that incidental, localized, and generalized EOP are heterogenous groups comprising rapidly and slowly progressing forms within each classification. The findings suggest that a classification system in which subsets of the disease that are defined according to a combination of cross-sectional criteria and the disease progression may be useful in studies of EOP. Furthermore, the findings suggest that clinical classifications of EOP be used as generic descriptors until a full understanding of the pathogenesis of this disease is accomplished.
Demonstration of major histocompatibility complex restriction in man using an antigen-specific proliferating T cell clone. (1982)

An antigen-specific, proliferating T cell clone was obtained by soft agar cloning from peripheral blood mononuclear leukocytes (PBML) of a normal human volunteer immunized with keyhole limpet hemocyanin (KLH). In addition to antigen, presenting cells from donors histocompatible at the HLA-D locus were required to stimulate a proliferative response by this clone. Although the donor of the T cell clone was heterozygous at the HLA-D locus (DRw2/6Y), only PBML from the one parent and random donors possessing DRw2 would support a proliferative response to KLH. PBML from the DRw6Y-bearing parent and other DRw6Y-bearing random donors would not present KLH. This result demonstrates unequivocally that the phenomenon of major histocompatibility complex-restricted antigen recognition by T lymphocytes is operative in man.
ChemInform Abstract: NEW ANALOGS OF SOMATOSTATIN WITH UNEXPECTED EFFECTS IN VIVO ON INSULIN BASAL SECRETION IN THE RAT (1) (1985)

Abstract 20 Analoge (Ib)‐(VII) von Somatostatin (Ia) mit Taurin, Azaalanin und D‐Aminosäuren als Bausteinen oder mit fehlenden Bausteinen werden teils nach der Fragmentkondensationsmethode [(Ib)‐(IVb)], teils nach dem Festphasen‐Verfahren ‐ durch schrittweisen Aufbau vom C‐terrninalen Cys‐ Rest aus ‐ synthetisiert, um möglicherweise Verbindungen mit größerer spezifischer Wirksamkeit (Hemmung der Freisetzung von Insulin oder Glucagon) zu gewinnen.