gebhart/patrepeval huggingface dataset:
p27Kip1 Is Important in Modulating Pulmonary Artery Smooth Muscle Cell Proliferation (2001)

Vascular remodeling due to pulmonary arterial smooth muscle cell (PASMC) proliferation is central to the development of pulmonary hypertension. Cell proliferation requires the coordinated interaction of cyclins and cyclin-dependent kinases (cdk) to drive cells through the cell cycle. Cdk inhibitors can bind cyclin-cdk complexes and cause G(1) arrest. To determine the importance of the cdk inhibitor p27(Kip1) in PASMC proliferation we studied [(3)H]thymidine incorporation, changes in cell cycle, cell proliferation, and protein expression of p27(Kip1) following serum stimulation in early passage rat PASMC. p27(Kip1) expression decreased to 40% of baseline after serum stimulation, which was associated with an increase in both [(3)H]thymidine incorporation and the percent of cells in S phase. p27(Kip1) binding to cyclin E decreased at 24 h, and this correlated with an increase in phosphorylation of retinoblastoma both in vivo and in vitro. Overexpression of p27(Kip1) decreased [(3)H]thymidine incorporation and reduced cell counts at 5 d compared with controls. PASMC obtained from p27(Kip1-/-) mice showed a 2-fold increase in [(3)H]thymidine incorporation (at 24 h) and cell proliferation compared with p27(Kip1+/+) PASMC when cultured in 10% fetal bovine serum (FBS). These results suggest an important role for p27(Kip1) in regulating PASMC mitogenesis and proliferation.
Comprehensive Genetic Analysis of Follicular Thyroid Carcinoma Predicts Prognosis Independent of Histology (2018)

Though the number and variety of somatic variants are similar in the different histopathological subtypes of FTC in our study, mutational burden was an independent predictor of mortality and recurrence.
Abstract 105: 24/7 In-House Consultant Staffing for Cardiac Surgical ICU Patients: A Cost-Effective Model (2012)

Introduction: Intensive care staffing models vary amongst institutions. There is increasing evidence that in-house consultant care is beneficial in the intensive care unit. We have previously published beneficial results associated with 24-hour / 7-days a week in-house consultants working in a dedicated post-cardiac surgical unit. The cost-effectiveness of employing 24-hour / 7-days a week in-house consultants (both in the postoperative cardiac surgery and the general systems intensive care unit settings) remains largely unknown. The objective of this study was to analyze the cost implications of such a model. Methods: Using a prospectively collected database, an observational before and after cohort analysis of consecutive patients undergoing a cardiac surgical procedure at a single tertiary center was performed. The control cohort (n=1425) consisted of patients admitted to a traditional mixed surgical intensive care unit (SICU) from Jan.2005 - Jan.2007. The intervention cohort (n=1824) consisted of patients admitted to a newly created cardiac surgery ICU (CICU) from Jan.2007 - Sept.2008, which was staffed by 24/7 in-house consultants. Cost estimates were calculated for each patient from time of ICU admission to hospital discharge. For comparison purposes, propensity analysis was performed matching both cohorts on over twenty clinical, physiological, and surgical variables. Results: 1,182 patients (83%) per cohort were matched. Pre-operative demographics and surgical variables were similar between both cohorts. The CICU model was associated with a significant decrease in mean hospital bed, laboratory, and blood transfusion costs (Table 1). A higher mean ICU consultant salary cost offset this. Total estimated median cost was ∼14% lower in the CICU model relative to the SICU model (Table 1). Conclusions: We present a large before-after observational study examining the cost-effectiveness of 24/7 ICU consultant staffing. Our data suggests that the greater savings associated with improvement in post-operative care offsets the salary costs associated with 24/7 in-house consultants.
ChemInform Abstract: Isoxazoline Oxidation. An Efficient Method for the Preparation of α,β‐Unsaturated Carbonyl Compounds. (1987)

Abstract The isoxazolines (III), prepared from the nitrones (I) and the electron‐deficient alkynes (II), are oxidized with peracid to yield the unsaturated ketones (IV).
The effect of Brownian diffusion on shear-induced coagulation of colloidal dispersions (1983)

The effect of a small amount of Brownian diffusion on shear-induced coagulation of spherical particles has been calculated. This has been accomplished by considering the binary collision process between a test sphere and identical spheres interacting with the test sphere through induced-dipole attraction, electrostatic repulsion and hydrodynamically induced forces. The effect of diffusion is found by means of an expansion in inverse Péclet number. Specific calculations were performed for uniaxial extension and for laminar shear flow. It is found that Brownian diffusion, the effect of which is nonlinearly coupled with flow type and strength, can act to increase or decrease the coagulation rate.
The v-erbA oncogene requires cooperation with tyrosine kinases to arrest erythroid differentiation induced by ligand-activated endogenous c-erbA and retinoic acid receptor. (1992)

The v-erbA oncogene, a mutated version of the thyroid hormone receptor alpha (c-erbA/TR-alpha), cooperates with tyrosine kinase oncogenes in erythroblast transformation. Here we show that the ligand-activated, endogenous retinoic acid receptor (RAR-alpha), in cooperation with c-erbA/TR-alpha, efficiently reverses the transforming effect of kinase oncogenes, overcoming oncogene-induced self-renewal by triggering terminal differentiation of the transformed cells into healthy erythrocytes. This differentiation induction was accompanied by up-regulation of erythrocyte gene expression. Similarly, RAR-alpha and over-expressed exogenous c-erbA/TR-alpha efficiently abolished the differentiation arrest caused by v-erbA, while the low levels of endogenous TR-alpha had no effect. In contrast, transformation by v-erbA plus a kinase oncogene was not affected at all by ligand-activated endogenous or over-expressed exogenous TR-alpha and RAR-alpha. These results suggest that oncogene cooperation is required to protect leukemic erythroblasts from differentiation induction via endogenous, nuclear hormone receptors. Endogenous c-erbA/TR-alpha and RAR-alpha apparently cooperated in abolishing erythroblast self-renewal and inducing differentiation, since the respective ligands acted in a synergistic fashion, and overexpressed, non-ligand-bound c-erbA/TR-alpha suppressed endogenous RAR-alpha function in differentiation induction. Genetic evidence is presented that this functional cooperation requires the receptor dimerization domain, suggesting that TR-alpha/RAR-alpha heterodimers play a role in regulation of erythroid differentiation.
Correlation Dimension of the Human Electroencephalogram Corresponds with Cognitive Load (2000)

This study aimed at assessing the effects of cognitive activity and mental task load on the correlation dimension of the human electroencephalogram (EEG). Three experimental conditions were created: a baseline condition and two cognitive task conditions, a calculation task and a time estimation task. The calculation task was supposed to induce a higher mental load than the time estimation task, which is regarded as a less complex one. This was verified by a subjective rating scale. All conditions differed significantly in subjective estimated task load. The correlation dimension appeared to be higher in both task conditions compared to the baseline condition. A comparison of the two tasks indicated that the difference in correlation dimension between calculation and time estimation was also significant, with the highest value for calculation. It is concluded that cognitive and mental activity is associated with a higher correlation dimension in the EEG. This implies that the correlation dimension is a sensitive parameter in the analysis of electrical brain activity.
Successful Formulation and Application of Plant Growth-PromotingKosakonia radicincitansin Maize Cultivation (2018)

The global market for biosupplements is expected to grow by 14 percent between 2014 and 2019 as a consequence of the proven benefits of biosupplements on crop yields, soil fertility, and fertilizer efficiency. One important segment of biosupplements is plant growth-promoting bacteria (PGPB). Although many potential PGPB have been discovered, suitable biotechnological processing and shelf-life stability of the bacteria are challenges to overcome for their successful use as biosupplements. Here, the plant growth-promoting Gram-negative strain <i>Kosakonia radicincitans</i> DSM 16656<sup>T</sup> (family Enterobacteriaceae) was biotechnologically processed and applied in the field. Solid or liquid formulations of <i>K. radicincitans</i> were diluted in water and sprayed on young maize plants (<i>Zea mays</i> L.). Shelf-life stability tests of formulated bacteria were performed under 4°C and -20°C storage conditions. In parallel, the bacterial formulations were tested at three different farm level field plots characterized by different soil properties. Maize yield was recorded at harvest time, and both formulations increased maize yields in silage as well as grain maize, underlining their positive impact on different agricultural systems. Our results demonstrate that bacteria of the family <i>Enterobacteriaceae,</i> although incapable of forming spores, can be processed to successful biosupplements.
A Multi-User Computer-Aided Design Competition: Experimental Findings and Analysis of Team-Member Dynamics (2017)

A competition for teams of three students using a prototype multi-user computer-aided design (MUCAD) tool was held to investigate various hypotheses regarding the performance of teams in such a setting. By comparing models from the competition to the same model in a single-user CAD environment, it is seen that use of a MUCAD system can significantly increase the value-added per unit of calendar time for a modeling effort. An investigation was also made into the causes of the performance differences among the various MUCAD teams which participated in the competition. Analysis of the results shows that teams that encouraged effective forms of communication and teams whose members scored similarly on the Purdue Spatial Visualization Test: Visualization of Rotations (PSVT:R) performed better than other teams. Areas of future research in analyzing teams in MUCAD environments are suggested.
Conclusions and Future Outlook (2021)

Nearly half a century of research on atomic clusters has revealed many exciting and unexpected properties of this new phase of matter. This book summarizes the recent developments in the rational design of superatoms using different electron-counting rules, applied individually or in combination. One-, two-, and three-dimensional cluster-based materials and their application in energy harvesting (solar cells), energy storage (batteries), energy conversion (thermoelectrics), CO 2 capture and conversion, and ferroelectrics are also illustrated. Cluster science, once motivated by our desire to learn how properties evolve from clusters to crystals, has entered a new phase where atom-precise clusters are used to build a new class of materials. Consequently, cluster science has now bridged physics, chemistry, and materials science.
Estimating Body Segment Orientation by Applying Inertial and Magnetic Sensing Near Ferromagnetic Materials (2007)

Inertial and magnetic sensors are very suitable for ambulatory monitoring of human posture and movements. However, ferromagnetic materials near the sensor disturb the local magnetic field and, therefore, the orientation estimation. A Kalman-based fusion algorithm was used to obtain dynamic orientations and to minimize the effect of magnetic disturbances. This paper compares the orientation output of the sensor fusion using three-dimensional inertial and magnetic sensors against a laboratory bound opto-kinetic system (Vicon) in a simulated work environment. With the tested methods, the difference between the optical reference system and the output of the algorithm was 2.6 degrees root mean square (rms) when no metal was near the sensor module. Near a large metal object instant errors up to 50 degrees were measured when no compensation was applied. Using a magnetic disturbance model, the error reduced significantly to 3.6 degrees rms.
Advances in New Zealand mammalogy 1990–2000: House cat (2001)

(2001). Advances in New Zealand mammalogy 1990–2000: House cat. Journal of the Royal Society of New Zealand: Vol. 31, No. 1, pp. 205-218.
Boundary handling for convolutional sparse representations (2016)

Convolutional sparse representations differ from the standard form in representing the signal to be decomposed as the sum of a set of convolutions with dictionary filters instead of a linear combination of dictionary vectors. The advantage of the convolutional form is that it provides a single-valued representation optimised over an entire signal. The substantial computational cost of the convolutional sparse coding and dictionary learning problems has recently been shown to be greatly reduced by solving in the frequency domain, but the periodic boundary conditions imposed by this approach have the potential to create boundary artifacts. The present paper compares different approaches to avoiding these effects in both sparse coding and dictionary learning.
Nitrogen fixation (C2H2 reduction) by Medicago nodules and bacteroids under sodium chloride stress (1987)

Medicago ciliaris (L.) All., a salt‐tolerant legume, was not nodulated by Rhizobium meliloti (2011), a strain commonly used for field inoculation of alfalfas. A strain of Rhizobium meliloti (ABS7) was isolated from saline Algerian soils. It is generally more salt‐resistant than strain 2011, exhibits a higher rate of growth and induces the formation of nodules on M. ciliaris . C 2 H 2 reduction activity of M. ciliaris nodules was inhibited by 50% in the presence of 200 m M NaCl in the culture medium. whereas 100 m M NaCl was sufficient to inhibit the activity of nodules of M. sativa (L. cv. Europe). C 2 H 2 reduction by bacteroids, isolated from nodules of the two species of alfalfa, was directly inhibited by the presence of NaCl in the incubation medium. In both cases, glucose could support bacteroid nitrogen fixation, but only in a narrow range of O 2 tensions. Bacteriods from M. ciliaris were more tolerant to salt than M. sativa ones. The salt resistance of bacteroids from nodules of plants watered with NaCl solutions was not improved in either species. Salt directly added to the incubation mixture of bacteroids or to the culture medium of plants inhibited O 2 uptake of bacteroids isolated from nodules of both M. ciliaris and M. sativa . The depressive effect of NaCl on bacteroid C 2 H 2 reduction could be directly related to the drop in bacteroid respiration. The nitrogen fixation capacity of the M. ciliaris‐Rhizobium meliloti (ABS7) symbiosis under saline conditions leads us to recommend the introduction of this association in salt‐troubled areas.
Determination of Long-Chain Alkyl Sulfates as Chloroform-Soluble Azure A Salts. (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of Long-Chain Alkyl Sulfates as Chloroform-Soluble Azure A Salts.J. van Steveninck and J. C. RiemersmaCite this: Anal. Chem. 1966, 38, 9, 1250–1251Publication Date (Print):August 1, 1966Publication History Published online1 May 2002Published inissue 1 August 1966https://pubs.acs.org/doi/10.1021/ac60241a033https://doi.org/10.1021/ac60241a033research-articleACS PublicationsRequest reuse permissionsArticle Views69Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Statistical bias in the assessment of binaural benefit relative to the better ear (2011)

The comparison of measured binaural performance with the better of two monaural measures (one from each ear) may lead to underestimated binaural benefit due to statistical sampling bias that favors the monaural condition. The mathematical basis of such bias is reviewed and applied to speech reception thresholds measured in 32 bilateral cochlear implant (CI) users for coincident and spatially separated speech and noise. It is shown that the bias increases with test-retest variation and is maximal for uncorrelated samples of identical underlying performance in each ear. When measured differences between ears were assumed to reflect actual underlying performance differences, the bias averaged across the CI users was about 0.2 dB for coincident target and noise, and 0.1 dB for spatially separated conditions. An upper-bound estimate of the bias, based on the assumption that both ears have the same underlying performance and observed differences were due to test-retest variation, was about 0.7 dB regardless of noise location. To the extent that the test-retest variation in these data is comparable to other studies, the results indicate that binaural benefits in bilateral cochlear implant users are not substantially underestimated (on for average) when binaural performance is compared with the better ear in each listening configuration.
Preliminary evaluation of nanoscale biogenic magnetite in Alzheimer's disease brain tissue (2003)

Elevated iron levels are associated with many types of neurodegenerative disease, such as Alzheimer's, Parkinson's and Huntington's diseases. However, these elevated iron levels do not necessarily correlate with elevated levels of the iron storage or transport proteins, ferritin and transferrin. As such, little is known about the form of this excess iron. It has recently been proposed that some of the excess iron in neurodegenerative tissue may be in the form of the magnetic iron oxide magnetite (Fe(3)O(4)). We demonstrate, for the first time to our knowledge, using highly sensitive superconducting quantum interference device (SQUID) magnetometry, that the concentrations of magnetite are found to be significantly higher in three samples of Alzheimer's disease tissue than in three age- and sex-matched controls. These results have implications, not only for disease progression, but also for possible early diagnosis.
Alzheimer’s disease specific MRI brain regions are differentially associated with accelerated decline as defined using sigmoidal cognitive turning point methodology in amyloid‐positive AIBL participants (2022)

Abstract Background Variability in cognitive decline among adults with Alzheimer’s disease (AD) is seen across studies. While such variability is often modelled using linear models, in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study, application of a sigmoidal methodology has shown excellent precision in modelling cognitive and biomarker changes. Here we expand these findings by examining associations of brain volumes in AD specific Regions of Interest (ROIs) with accelerated cognitive decline among amyloid‐beta positive (Ab+) AIBL participants. Method Longitudinal cognitive scores for the AIBL PACC, Language, Visuospatial functioning and CDR‐SB were mapped to sigmoidal trajectories, with a threshold defining the inflection point of accelerated cognitive decline. Participants to the left of the threshold were classified as having non‐accelerated decline (non‐accelerators), and participants beyond the threshold were classed as accelerators (Figure 1B). Using these classifications, we investigated differences in 16 ICV corrected ROI (left and right hemispheres pooled) for reductions in brain volume via generalised linear models adjusted for age, gender, and APOE‐e4 status. Three participant subgroups were tested: 1) Ab+/Tau unknown, 2) Ab+/Tau‐ and 3) Ab+/Tau+. Significant t‐values for the summed ROI volumes were mapped on a standard brain mesh for visualisation. Result Of regions tested, two stood out consistently amongst top markers in each of the participant subgroups and cognitive outcomes: 1) supramarginal volume and 2) middle temporal volume (Figure 1C). Largest volume differences between accelerators and non‐accelerators were seen in the Ab+/Tau+ group; whilst smallest p‐values were in the Ab+/Tau unknown group due to a larger sample size (Table 1). Brain mesh visualization showed most of the AD signature ROIs altered in accelerator groups as compared with non‐accelerator groups. Figure 1D shows the AD signature for each cognitive outcome amongst the Ab+/Tau participant group. Top ranked ROI for the left being middle temporal volume (T=7.10, PACC) and supramarginal volume (T=7.10, CDR‐SB). Conclusion Sigmoid analyses of MRI using binary cognitive scores show decreased ROI volumes in AIBL Ab+ participants with accelerated cognitive decline. This effect was mediated by known information on Tauopathy. Whilst effect sizes were high, smaller sample sizes in some groups affected p‐values and should therefore be replicated in larger samples.
Comparison of two modeling approaches of eddy current industrial non-destructive testing of steel pipes (2014)

In the framework of the COFREND working group "Eddy current modeling", a benchmark has been proposed by the Vallourec research center. This case corresponds to the modeling of an industrial online testing of seamless steel pipes by eddy current method with encircling coils. The centering of the steel pipe in the coil is not considered as perfect and a shift is imposed to the pipe. For this benchmark, the Vallourec research center (VRA, Vallourec Research Aulnoye) has compared two solutions with different approaches: the first one is based on semi-analytical methods through the CIVA software developed by the CEA, the second one on finite element method through the software Flux. Results for these two approaches are very similar between them and coherent to experimental data. It proves that these two simulations methods are valid and could be used as a complementary approach.
Experimental observation of whispering gallery modes in novel silicon microcylindrical resonators (2011)

Experimental observation of whispering gallery modes in novel silicon microcylindrical resonator is reported. Silicon fibres are fabricated using a high pressure chemical deposition technique to fill silica capillaries with the semiconductor material. This process can be easily modified to fill capillaries of various internal diameters with the deposited material taking on the pristine smoothness of the capillary walls (0.1 nm RMS).
An enhanced framework for real-time hair animation (2004)

Maximizing visual effect is a major problem in real-time animation. A real-time hair animation framework was proposed previously by C. K. Koh and Z. Huang (2000, 2001) based on 2D representation and texture mapping. One problem is that it lacks of the volumetric effect due to its 2D nature. This paper presents a technique using the U-shape strip to solve the problem.