gebhart/patrepeval huggingface dataset:
A Novel Protein-Bound Copper−Molybdenum Cluster (2000)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTA Novel Protein-Bound Copper−Molybdenum ClusterGraham N. George, Ingrid J. Pickering, Eileen Y. Yu, Roger C. Prince, Sergey A. Bursakov, Olga Yu. Gavel, Isabel Moura, and José J. G. MouraView Author Information Stanford Synchrotron Radiation Laboratory Stanford Linear Accelerator Center PO Box 20450, MS 69, Stanford, California 94309 ExxonMobil Research and Engineering Company Annandale, New Jersey 08801 Departmento de Química Centro de Química Fina e Biotecnologia Faculdade de Ciências e Tecnologia Universidade Nova de Lisboa, 2825 Monte de Caparica, Portugal Cite this: J. Am. Chem. Soc. 2000, 122, 34, 8321–8322Publication Date (Web):August 10, 2000Publication History Received17 March 2000Published online10 August 2000Published inissue 1 August 2000https://pubs.acs.org/doi/10.1021/ja000955hhttps://doi.org/10.1021/ja000955hrapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views744Altmetric-Citations85LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Extended X-ray absorption fine structure,Metal clusters,Molybdenum,Monomers,Peptides and proteins Get e-Alerts
The Hepcidin Regulator Erythroferrone is a New Member of the Erythropoiesis–Iron–Bone Circuitry (2021)

ABSTRACT Erythroblast erythroferrone (ERFE) secretion inhibits hepcidin expression by sequestering several bone morphogenetic protein (BMP) family members to increase iron availability for erythropoiesis. We report that ERFE expression in osteoblasts is higher compared with erythroblasts, is independent of erythropoietin, and functional in suppressing hepatocyte hepcidin expression. Erfe -/- mice display low–bone–mass arising from increased bone resorption despite a concomitant increase in bone formation. Consistently, Erfe -/- osteoblasts exhibit enhanced mineralization, Sost and Rankl expression, and BMP–mediated signaling ex vivo . The ERFE effect on osteoclasts is mediated through increased osteoblastic RANKL and sclerostin expression, increasing osteoclastogenesis in Erfe -/- mice. Importantly, Erfe loss in β–thalassemic ( Hbb th3 /+ ) mice, a disease model with increased ERFE expression, triggers profound osteoclastic bone resorption and bone loss. Together, ERFE exerts an osteoprotective effect by modulating BMP signaling in osteoblasts, decreasing RANKL production to limit osteoclastogenesis, and prevents excessive bone loss during expanded erythropoiesis in β–thalassemia.
Absorption of Electromagnetic Radiation by an Electron Gas (1963)

It is shown that the two individual electron excitation has larger contributions to the absorption of electromagnetic radiation than the process accompanied by plasmon emission. (R.E.U.)
Initial experience of laparoscopic resection of adrenal tumours. (1997)

Our initial experience supports that from other centres in that we found that the laparoscopic approach is suitable for resection of adrenal masses.
p62, A TFIIH Subunit, Directly Interacts with Thyroid Hormone Receptor and Enhances T3-Mediated Transcription (2004)

Currently, little is known about the direct interactions of general transcription factors and nuclear hormone receptors. To investigate the potential role of the general transcription factor, TFIIH, in T3-mediated transcriptional activation, we examined thyroid hormone receptor (TR) interaction with individual TFIIH subunits in a yeast-two hybrid system. Among the nine subunits of TFIIH studied, only p62 subunit interacted with TRbeta in a ligand-dependent manner. Glutathione-S-transferase pull-down and in vivo coimmunoprecipitation studies also demonstrated direct TR/p62 interaction. Using chromatin immunoprecipitation assays, we showed that TFIIH subunits were corecruited on or near an endogenous thyroid hormone response element upon T3 addition. Cotransfection studies with TSA201 cells showed that p62 increased T3-mediated transcription, which could be further enhanced when p62 and another TFIIH subunit, p44, were cotransfected simultaneously. Taken together, these data suggest that TRs can interact directly with a subunit of TFIIH and may provide an alternative pathway for nuclear receptor communication with the general transcription machinery that circumvents coactivators.
On Dyakonov–Voigt surface waves guided by the planar interface of dissipative materials (2019)

Dyakonov–Voigt (DV) surface waves guided by the planar interface of (i) material $ {\cal A} $A, which is a uniaxial dielectric material specified by a relative permittivity dyadic with eigenvalues $ \varepsilon _{\cal A}^s $εAs and $ \varepsilon _{\cal A}^t $εAt, and (ii) material $ {\cal B} $B, which is an isotropic dielectric material with relative permittivity $ {\varepsilon _{\cal B}} $εB, are numerically investigated by solving the corresponding canonical boundary-value problem. The two partnering materials were generally dissipative, with the optic axis of material $ {\cal A} $A being inclined at the angle $ \chi \in [ {{0^ \circ },{{90}^ \circ }} ] $χ∈[0∘,90∘] relative to the interface plane. No solutions of the dispersion equation for DV surface waves exist when $ \chi = {90^ \circ } $χ=90∘. Also, no solutions exist for $ \chi \in ( {{0^ \circ },{{90}^ \circ }}) $χ∈(0∘,90∘), when both partnering materials are nondissipative. For $ \chi \in [ {{0^ \circ },{{90}^ \circ }} ) $χ∈[0∘,90∘), the degree of dissipation of material $ {\cal A} $A has a profound effect on the phase speeds, propagation lengths, and penetration depths of the DV surface waves. For mid-range values of $ \chi $χ, DV surface waves with negative phase velocities were found. For fixed values of $ \varepsilon _{\cal A}^s $εAs and $ \varepsilon _{\cal A}^t $εAt in the upper-half-complex plane, DV surface-wave propagation is only possible for large values of $ \chi $χ when $ |{\varepsilon _{\cal B}}| $|εB| is very small.
Evaluation of dynamic binaural reproduction system for live transmitted xylophone recording (2012)

For a special teaching application of the telepresence research project BEAMING, a scenario of a remote teacher (the Visitor) teaching a local student to play a xylophone through an embodiment is defined. In order to achieve this, a system is required to record, transmit and render the sound of the xylophone to the teacher in a dynamic scene. In an implementation of such a system, the xylophone is recorded using a mono recording technique. The signal is then processed to spread out the sound of the distributed sound source as multiple point sources in the virtual scene experienced by the Visitor. Finally head tracking allows for a dynamic binaural rendering of the xylophone sound. The goal of this paper is to evaluate the realism of this virtual (auditory) representation of a real xylophone. A listening test is designed to compare characteristics of a real physical xylophone in front of the listener with a rendering using the described system. The evaluation is done with a basis in methods previously used for evaluating the subjective sensation of presence in virtual reality systems, mainly based on questionnaires.
Reversible Switching of Optical Phase Change Materials Using Graphene Microheaters (2019)

We demonstrate, for the first time, nonvolatile tunable photonics that makes use of graphene microheaters to thermally switch large-area, low-loss phase change materials. This framework enables scalable nonvolatile integrated photonics and free-space optics applications.
Computational and experimental characterization of the novel ECM glycoprotein SNED1 and prediction of its interactome (2020)

ABSTRACT The extracellular matrix (ECM) protein SNED1 has been shown to promote breast cancer metastasis and control neural crest cell-specific craniofacial development, but the cellular and molecular mechanisms by which it does so remain unknown. ECM proteins exert their functions by binding to cell surface receptors, sequestering growth factors, and interacting with other ECM proteins, actions that can be predicted using knowledge of protein’s sequence, structure and post-translational modifications. Here, we combined in-silico and in-vitro approaches to characterize the physico-chemical properties of SNED1 and infer its putative functions. To do so, we established a mammalian cell system to produce and purify SNED1 and its N-terminal fragment, which contains a NIDO domain. We have determined experimentally SNED1’s potential to be glycosylated, phosphorylated, and incorporated into insoluble ECM produced by cells. In addition, we used biophysical and computational methods to determine the secondary and tertiary structures of SNED1 and its N-terminal fragment. The tentative ab-initio model we built of SNED1 suggests that it is an elongated protein presumably able to bind multiple partners. Using computational predictions, we identified 114 proteins as putative SNED1 interactors. Pathway analysis of the newly-predicted SNED1 interactome further revealed that binding partners of SNED1 contribute to signaling through cell surface receptors, such as integrins, and participate in the regulation of ECM organization and developmental processes. Altogether, we provide a wealth of information on an understudied yet important ECM protein with the potential to decipher its functions in physiology and diseases.
Monolithically Integrated DFB-EA for 100 Gb/s Ethernet (2008)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> The world's first monolithically integrated distributed feedback laser and electroabsorption (EA) modulator with an expected <formula formulatype="inline"><tex Notation="TeX">$\geq$</tex></formula>100 GHz <formula formulatype="inline"><tex Notation="TeX"> $-$</tex></formula>3 dBe bandwidth suitable for 100 Gb/s operation with on–off keying is presented. The design of the EA modulator uses a traveling-wave structure with three active segments and a total active length of 180 <formula formulatype="inline"><tex Notation="TeX">$\mu\hbox{m}$</tex></formula> resulting in <formula formulatype="inline"><tex Notation="TeX">$ \sim$</tex></formula>2.5 V peak-to-peak drive voltage for 10 dB optical extinction ratio and low electrical reflection. </para>
Isolation and functional analysis of sporulation-induced transcribed sequences from Saccharomyces cerevisiae. (1986)

Strains of the yeast Saccharomyces cerevisiae that are heterozygous for the mating-type locus (MATa/MAT alpha) undergo meiosis and spore formation when they are starved for nitrogen and are provided with a nonfermentable carbon source such as potassium acetate. Haploids and diploids homozygous for the mating-type locus (MAT alpha/MAT alpha or MATa/MATa) are asporogenous and undergo neither meiosis nor spore formation when incubated under the same conditions. A small number of genes produce transcripts that appear to be induced specifically in sporulating cells. These transcripts either are not found or are present at much lower levels both in vegetatively growing cells and in cells from asporogenous strains that have been incubated in sporulation medium. Several genes complementary to these MATa/MAT alpha-dependent sporulation-induced transcripts were isolated from a gene-size insert yeast-lambda recombinant DNA library, by differential-plaque filter hybridization. An attempt was made to determine the function of three of these genes by mutating them in the yeast genome with in vitro mutagenesis and one-step gene replacement techniques. One gene was extensively disrupted by both a 0.3-kilobase deletion and the insertion of two large DNA sequences at different sites within the gene. Surprisingly, this compound mutation did not appear to affect meiosis or the production of viable ascospores, indicating that this gene was dispensable for differentiation. The other two genes were disrupted by simple insertion mutations at a site where it was possible that they might still possess some gene activity. These mutations also did not appear to affect sporulation. These results suggest that not all sporulation-induced genes are essential for meiosis and the production of viable ascospores under the conditions examined.
Intelligent wide-area resistance surveillance: a novel approach using the semantic web (2011)

Proper surveillance of infectious diseases poses special challenges to information technology when it comes to data collection, including wide-area, multi-source and trans-border collection and aggregation of infectious disease and drug resistance information. In this project, we present a novel approach to efficiently monitor bacterial resistance data over multiple international clinical entities.
Hormone therapy and urinary incontinence (2012)

Menopause: The Journal of The North American Menopause Society 19(3):p 255-256, March 2012. | DOI: 10.1097/gme.0b013e31824e9bb0
Proteomics Analyses of Human Optic Nerve Head Astrocytes Following Biomechanical Strain (2011)

We investigate the role of glial cell activation in the human optic nerve caused by raised intraocular pressure, and their potential role in the development of glaucomatous optic neuropathy. To do this we present a proteomics study of the response of cultured, optic nerve head astrocytes to biomechanical strain, the magnitude and mode of strain based on previously published quantitative models. In this case, astrocytes were subjected to 3 and 12% stretches for either 2 h or 24 h. Proteomic methods included nano-liquid chromatography, tandem mass spectrometry, and iTRAQ labeling. Using controls for both stretch and time, a six-plex iTRAQ liquid chromatography- tandem MS (LC/MS/MS) experiment yielded 573 proteins discovered at a 95% confidence limit. The pathways included transforming growth factor β1, tumor necrosis factor, caspase 3, and tumor protein p53, which have all been implicated in the activation of astrocytes and are believed to play a role in the development of glaucomatous optic neuropathy. Confirmation of the iTRAQ analysis was performed by Western blotting of various proteins of interest including ANXA 4, GOLGA2, and αB-Crystallin.
Modified Screen-Printed Carbon Electrodes with Tyrosinase for Determination of Phenolic Compounds in Smoked Food (2010)

A screen-printed carbon electrode modified with tyrosinase (SPCE-Tyr/Paa/Glut) has been developed for the determination of phenol concentration in real samples. The resulting SPCE-Tyr/Paa/Glut was prepared in a one-step procedure, and was then optimized as an amperometric biosensor operating at 0 mV versus Ag/AgCl for phenol determination in flow injection mode. Phenol detection was realized by electrochemical reduction of quinone produced by tyrosinase activity. The possibility of using the developed biosensor to determine phenol concentrations in various smoked products (bacon, ham, chicken and salmon) was also evaluated. Gas chromatography (GC) method was used for result validation obtained in flow injection mode using amperometric biosensor. The result showed good correlation with those obtained by flowinjection analysis (FIA).
Sound Alerter Powered Over an Optical Fiber (1978)

An optically powered sound alerter has been constructed which demonstrates the feasibility of converting optical power into sound power with good efficiency and at power levels comparable to those of present telephone ringers. The alerter has an overall optical-to-acoustic efficiency of about 35 percent at 2 mW of acoustic output power. Optical power is converted to electrical power by a 52-percent efficient photovoltaic detector and then into acoustical power by a 72-percent efficient electroacoustic tone generator which uses a piezoelectric transducer. This demonstration establishes that it is technically feasible to deliver optically, via a fiber lightguide, sufficient power to operate a telephone, since all other telephone signaling functions can be accomplished, in principle, with less power and within the context of dielectric lightguide technology. For conventional usage, the design of a telephone alerter must take many factors into consideration, including background noise masking, frequencies not irritating to the customer, satisfactory performance for customers with impaired hearing, etc. These factors have not been addressed here.
Supreme Court Procedure in Michigan (1934)

The papers constituting this symposium were addresses delivered to the Indiana State Bar Association at its Thirty-eighth Annual Meeting, Lake Wawasee, July 12 and 13, 1934.
Federal Register document image database: (1998)

A new, fully-automated process has been developed at NIST to derive ground truth for document images. The method involves matching optical character recognition (OCR) results from a page with typesetting files for an entire book. Public domain software used to derive the ground truth is provided in the form of Perl scripts and C source code, and includes new, more efficient string alignment technology and a word-level scoring package. With this ground truthing technology, it is now feasible to produce much larger data sets, at much lower cost, than was ever possible with previous labor-intensive, manual data collection projects. Using this method, NIST has produced a new document image database for evaluating Document Analysis and Recognition technologies and Information Retrieval systems. The database produced with this method contains scanned images, SGML-tagged ground truth text, commercial OCR results, and image quality assessment results for pages published in the 1994 Federal Register. These data files are useful in a wide variety of experiments and research. There were roughly 250 issues, comprised of nearly 69,000 pages, published in the Federal Register in 1994. This volume of the database contains the pages of 20 books published in January of that year. In all, there are 4711 page images provided, with 4519 of them having corresponding ground truth. This volume is distributed on two ISO-9660 CD-ROMs. Future volumes may be released, depending on the level of interest.
[Effect of amrinone and trapidil on adherence, migration and phagocytic behavior of neutrophilic granulocytes of the human]. (1987)

Amrinone and trapidile belong to a group of positive inotropic and simultaneously vasodilating substances, whose effects are based on an inhibition of phosphodiesterase (PDE), thus enriching intracellular c-AMP. In neutrophilic granulocytes these PDE-antogonists will produce an inhibition of adherence and phagocytosis, whereas the migration was not affected. The lower leukocyte effective concentration of 10 mmol/l can be achieved by a therapeutical application, so that a slight inhibition of the leukocyte function has to be accounted for as a side effect.
Smart Expandable Fiber Additive To Prevent Formation of Microannuli (2020)

Summary One of the critical issues that occur in many oil and gas wells is the failure of the cement sheath because of debonding from the casing string or from the formation. This results in the formation of microannuli, which can become pathways for fluid migration. Cement shrinkage during setting is regarded as one of the main causes of the formation of microannuli. In this paper, a new class of polymer-based expandable additives in the form of fibers is incorporated into the cement to compensate for shrinkage and thereby help prevent the formation of microannuli in oil and gas wells. The proposed fiber additives are made from shape-memory polymers (SMPs) and expand when exposed to temperatures above a specific value that is, by design, below the downhole temperature of the cemented zone. Fiber expansion occurs after the placement of the cement slurry but before its setting to avoid the inducement of any microfractures. As a result of the expansion of the cement paste, flow channels and fluid migration may significantly decrease while preserving the mechanical properties required for the mechanical integrity of the cement sheath. The bridging effect of fibers across individual microcracks helps control the propagation and coalescence of small fractures. Considering the inert property of the proposed additive, the water-cement ratio and its chemical properties do not need to be revisited. The measured increase in cement ductility makes the cement system more resistant to cracking. The cement expansion, fluid loss, gel strength, compressive strength, ductility, and tensile strength of the samples containing these fibers are examined using destructive and nondestructive methods, as reported here. The proposed class of expandable additives can help operators reach sustainable well integrity by increasing the contact stress at the cement–casing and the cement–formation interfaces to prevent fluid migration and the propagation of cracks.
Beiträge zur Optik trüber Medien, speziell kolloidaler Metallösungen (1908)

~+ 5 ) ( 2 v + 7 ) '??+ ' * ' )
Template-Directed Synthesis of a Rotacatenane (1999)

A [2]catenane, able to bind π-electron-rich guests inside the cavity of one of its two macrocyclic components has been designed and synthesized using supramolecular assistance. This recognition motif has been exploited to template the formation of a so-called rotacatenane – i.e., a molecule composed of a dumbbell-shaped component threaded through the cavity of one of the two mechanically interlocked macrocyclic components of a [2]catenane. The structure of this [2]catenane, as well as that of a model [2]catenane, have been characterized unequivocally by single-crystal X-ray analyses. Furthermore, some of the co-conformational changes associated with these mechanically interlocked molecules in solution have been probed by variable-temperature 1H-NMR spectroscopy.
Glutathione Peroxidase 1 Is Regulated by the c-Abl and Arg Tyrosine Kinases (2003)

The c-Abl and Arg tyrosine kinases are activated in the cellular response to oxidative stress. The present studies demonstrate that c-Abl and Arg associate with glutathione peroxidase 1 (GPx1) and that this interaction is regulated by intracellular oxidant levels. The c-Abl and Arg SH3 domains bind directly to a proline-rich site in GPx1 at amino acids 132-145. GPx1 also functions as a substrate for c-Abl- and Arg-mediated phosphorylation on Tyr-96. The results further show that c-Abl and Arg stimulate GPx activity and that these kinases contribute to GPx-mediated protection of cells against oxidative stress. Our findings provide the first evidence that GPx1 is regulated by a signaling pathway that is activated in the oxidative stress response.
Supplementary Table 5_Marker genes all and some per cluster no cell cycle_GO and curated pathways per cluster no cell cycle from A Rare Subset of Primary Tumor Cells with Concomitant Hyperactivation of Extracellular Matrix Remodeling and dsRNA-IFN1 Signaling Metastasizes in Breast Cancer (2023)

&lt;p&gt;Supplementary Table including Marker genes (ALL and SOME settings) per cluster upon cell cycle regression, and GO and curated pathways per cluster upon cell cycle regression&lt;/p&gt;