gebhart/patrepeval huggingface dataset:
Measurements of fluctuating pressure in a rectangular cavity in transonic flow at high Reynolds numbers (1992)

An experiment was performed in the Langley 0.3 meter Transonic Cryogenic Tunnel to study the internal acoustic field generated by rectangular cavities in transonic and subsonic flows and to determine the effect of Reynolds number and angle of yaw on the field. The cavity was 11.25 in. long and 2.50 in. wide. The cavity depth was varied to obtain length-to-height (l/h) ratios of 4.40, 6.70, 12.67, and 20.00. Data were obtained for a free stream Mach number range from 0.20 to 0.90, a Reynolds number range from 2 x 10(exp 6) to 100 x 10(exp 6) per foot with a nearly constant boundary layer thickness, and for two angles of yaw of 0 and 15 degs. Results show that Reynolds number has little effect on the acoustic field in rectangular cavities at angle of yaw of 0 deg. Cavities with l/h = 4.40 and 6.70 generated tones at transonic speeds, whereas those with l/h = 20.00 did not. This trend agrees with data obtained previously at supersonic speeds. As Mach number decreased, the amplitude, and bandwidth of the tones changed. No tones appeared for Mach number = 0.20. For a cavity with l/h = 12.67, tones appeared at Mach number = 0.60, indicating a possible change in flow field type. Changes in acoustic spectra with angle of yaw varied with Reynolds number, Mach number, l/h ratios, and acoustic mode number.
Some circular coverage problems (1961)

Journal Article Some circular coverage problems Get access GEORGE W. MORGENTHALER GEORGE W. MORGENTHALER The Martin Co.Denver, Colorado Search for other works by this author on: Oxford Academic Google Scholar Biometrika, Volume 48, Issue 3-4, December 1961, Pages 313–324, https://doi.org/10.1093/biomet/48.3-4.313 Published: 01 December 1961
A Prospective Economic Evaluation of Rapid Endovascular Therapy for Acute Ischemic Stroke (2021)

Results support the adoption of EVT as a treatment option for acute ischemic stroke, as the increase in costs associated with caring for EVT patients was recouped within the first year of stroke, and continued to provide cost savings over a patient's lifetime.Clinical Trial Registration: NCT01778335.
Pest Mobility, Market Share, and the Efficacy of Refuge Requirements for Resisance Management (2003)

Pest Mobility, Market Share, and the Efficacy of Refuge Requirements for Resisance Management
The thermal decomposition of an organometallic precursor for the preparation of YBa2Cu3O7−x (1997)

Why are the carrier densities of YBa 2 Cu 3 O 7−x smaller in thin films prepared by wet‐chemical methods than in those prepared by other methods? In order to answer this practically relevant question, the chemical reactions taking place need to be known exactly. The thermal decomposition of an organometallic precursor of YBa 2 Cu 3 O 7−x —an important step in the wet‐chemical preparation–has been investigated by the simultaneous application of dynamic and static characterization methods and the results are reported here.
Time-Domain Oscillographic Microwave Network Analysis Using Frequency-Domain Data (1974)

Oscillographic plots of various time-domain responses of microwave networks are generated by computer simulation, based upon measurements taken in the frequency domain. Frequency-response data are obtained with a computer-controlled automatic network analyzer, this information is processed in an associated computer, and selected time-domain responses are plotted immediately on an x-y recorder. Voltage versus time responses have been simulated for various excitations includlng impulse, step, and pulse-modulated RF waves. When impedance data are used, the plots are interpretable as from a time-domain reflectometer with high precision, high sensitivity, and high resolving power. As an oscillograph the rise time may be as short as 0.04 ns. In transmission 70 dB or more loss can be tolerated. In reflection measurements, the results are interpretable for discrete discontinuities with 40 dB or more return loss, and with separations on the order of 1 cm in space. In certain types of circuits, time-domain data can be used to reconstruct the frequency-domain response data in an approximate manner for separate parts of a network without separate measurements. In this manner, the interference of generator, load, and transducer mismatches can be substantially reduced.
Vitamin D Receptors Repress Basal Transcription and Exert Dominant Negative Activity on Triiodothyronine-mediated Transcriptional Activity (1996)

We have examined vitamin D receptor (VDR), thyroid hormone receptor (TR), and retinoid X receptor beta (RXR beta) binding to vitamin D response elements (VDREs), two thyroid hormone response elements (TREs) (DR4 and F2), and a retinoic acid response element (DR5). VDR/RXR bound well to the VDREs and to DR4 and DR5 using the electrophoretic mobility shift assay. Surprisingly, VDR/RXR also bound well to F2, which contains half-sites arranged as an inverted palindrome. In co-transfection experiments using CV-1 cells, we observed that VDR repressed basal transcription in the absence of ligand on DR3 and osteopontin VDREs and F2, but had no effect on DR4 or DR5. VDR selectively mediated ligand-dependent transcription on only VDREs. VDR also exhibited dominant negative activity as it blocked triiodothyronine (T3)-mediated transcriptional activity on DR4 and F2. These results demonstrate that VDR/RXR heterodimers can bind promiscuously to a wide range of hormone response elements, including inverted palindromes. Moreover, they show that unliganded VDRs, similar to TRs and retinoic acid receptors, can repress basal transcription. Last, they also suggest a novel repressor function of VDR on T3-mediated transcription which may be significant in tissues where VDR and TR are co-expressed.
Abstract 682: Targeting heat shock protein 90 with ganetespib for molecularly targeted therapy of gastric cancer (2015)

Abstract Gastric cancer (GC) remains the fifth most common cancer worldwide. Heat shock protein 90 (HSP90) has become an attractive therapeutic target in treating cancers, due to its abnormally high expression in cancers. Several successful cases of HSP90 inhibitors capable of inhibiting GC inspired us to try ganetespib, a clinically promising and actively investigated second-generation HSP90 inhibitor in GC treatment. In our study, we show that ganetespib dramatically reduced growth of MGC-803 and also significantly inhibited growth of SGC-7901 and MKN-28 in a dose-dependent manner. It induced G2/M cell-cycle arrest and apoptosis in all three cell lines, together with the related markers affected significantly. Mechanistically, ganetespib caused pronounced decrease of expression of classic HSP90 client proteins. Specifically, it greatly affected EGFR signaling cascades by dramatically decreasing levels of total EGFR and EGFR on cell membranes. EGFR knockdown also induced cell-cycle arrest and apoptosis accompanied with a decrease of several EGFR downstream proteins. These results strongly support EGFR signaling greatly contributes to the ganetespib inhibitory effects. Besides, we found the responses of GC cell lines to ganetespib correlated well with their EGFR expression levels: MGC-803, as well as AGS and BGC-803, with higher EGFR expression responded to ganetespib better, while SGC-7901 and MKN-28 with lower EGFR levels were much less sensitive to ganetespib. Though SGC-7901 and MKN-28 were not very sensitive to ganetespib, ganetespib worked synergistically with radiation and cisplatin in killing them. Importantly, ganetespib significantly inhibited growth of xenograft tumors in vivo as a single agent or in combination with cisplatin. Results of H&amp;E staining, TUNEL assays, and immunohistochemistry staining of pCDK1, EGFR, and Ki-67 revealed significant differences in ganetespib-treated tumors. Collectively, our data suggest that ganetespib, as a new potent treatment option, can be used for the molecularly targeted therapy of GC patients according to their expression profiles of EGFR. Note: This abstract was not presented at the meeting. Citation Format: Hanqing Liu, Jian Lu, Ye Hua, Peishan Zhang, Zhiquan Liang, Lingling Ruan, Caixia Lian, Haifeng Shi, Keping Chen, Zhigang Tu. Targeting heat shock protein 90 with ganetespib for molecularly targeted therapy of gastric cancer. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 682. doi:10.1158/1538-7445.AM2015-682
An Overview on Food Applications of the Instant Controlled Pressure-Drop Technology, an Innovative High Pressure-Short Time Process (2021)

Food processing systematically aims at meeting the needs of consumers who are looking for total high quality and perfect food safety. As the various thermal and non-thermal food preservation technologies often affect the natural properties in terms of sensation, flavor, texture, etc., instant controlled pressure drop (DIC) has been conceived as a relevant, innovative process in this field. DIC uses high saturated steam pressure and short duration to provide a new way to expand biological matrices, improve drying, decontaminate, and extract biologically active compounds, among other attributes. Therefore, this review focuses on describing the applications of DIC technology on a wide range of products such as foods and by-products that have been processed both in the laboratory and on an industrial scale. The application of DIC has shown the possibility of a significant leap in quality improvement and cost reduction in the food industry. DIC reduces the drying time of fruits and vegetables, and improves the extraction of essential oils, vegetable oils, and antioxidant components. It also provides strong decontamination, eliminates vegetative microorganisms and spores, and reduces non-nutritional and allergenic components. Over the past 33 years, this technology has continued to expand its food applications and improve its characteristics on an industrial scale. But there are still many food unit operations that can be taken to the next level with DIC.
Efeitos de herbicidas nos teores de macronutrientes e nas características tecnológicas da cana-de-açúcar (Saccharum spp.). I - Misturas de herbicidas em pós-emergência (1980)

A presente pesquisa foi conduzida em um Latossol Roxo, com 3,9% de matéria orgânica, na Usina São Carlos, município de Jaboticabal - SP com o objetivo de verificar o comportamento das principais misturas de herbicidas aplicadas em pós-emergência e suas possíveis interferências nos teores de macronutrientes, e no desenvolvimento da variedade CB 41-14. Os tratamentos utilizados com as respectivas doses do ingrediente ativo em kg/ha foram: ametryne + 2,4 - D (formulação comercial) a 1,47 - 2,03, diuron + 2,4 -D a 1,60 + 2,16; ametryne + 2,4-D a 1,60 + 2,16; alachlor + 2,4-D a 1,09 + 1,80; asulam + ioxynil - 2,4-D a 2,80 + 1,75; MCPA + 2,4-D a 0,83 + 0,83; oxadiazon + 2,4 -D a 0,50 + 2,16; ametryne + simazine + 2,4-D a 1,25 + 1,25 + 2,16; ametryne + secbumetone + 2,4-D a 2,00 + 2,00 + 2,16; diuron + hexazinone + surfatante a 0,80 + 0,45 + 0,5% e MCPA + 2,3,6-TBA + pendimethalin + surfatante a 1,50 + 0,48 + 0,66 + 0,5%. O controle das plantas daninhas foi avaliado através de contagens por espécie botânica e por avaliações visuais . Sobre a cultura os efeitos foram constatados pela contagem da brotação inicial, avaliações visuais dos efeitos fitotóxicos, análise dos teores de macronutrientes aos 5 e 8 meses, medidas do comprimento dos colmos, análise dos teores de fibra, pol, brix, % de cana e pureza, assim como valores de pol/ha, e peso de colmos por hectare. Não houve interferência das diferentes misturas de herbicidas na brotação inicial, no comprimento médio dos colmos, e nos teores de fibra, pol, brix e pureza por ocasião da colheita. Em relação às principais plantas daninhas presentes na área, que eram capim-colchão (Digitaria sanguinalis (L). Scop.) capim-coloniâo (Panicum maximum Jacq), beldroega (Portulacca oleracea L.) e caruru (Amaranthus spp), as melhores porcentagens de controle foram obtidas com as misturas de ametryne + 2,4-D, MCPA + 2,4-D, oxadiazon + 2,4-D, ametryne + secbumetone, diuron + hexazinone e MCPA + 2,3,6-TBA + pendimethalin. Aos cinco meses o teor de P foi diminuido pela mistura de ametryne + secbumetone + 2,4-D, e o teor de Ca decresceu pelas misturas de diuron + 2,4-D, ametryne + 2,4-D, alachlor + 2,4-D, asulam + ioxynil + 2,4-D, MCPA + 2,4-D, oxadiazon + 2,4-D, ametryne + simazine + 2,4-D e ametryne + secbumetone + 2,4-D. Já aos oito meses não houve diferença estatística para qualquer dos nutrientes estudados. Os teores de pol/ha e produção de colmos/ha não foram significativamente afetados por qualquer dos tratamentos quando comparados com a testemunha com capina. Todavia, todos os tratamentos apresentaram produção inferior a esta, sugerindo certa precaução com as aplicações pós-emergentes em canade-açúcar.
Logic Gates and Antisense DNA Devices Operating on a Translator Nucleic Acid Scaffold (2009)

A series of logic gates, "AND", "OR", and "XOR", are designed using a DNA scaffold that includes four "footholds" on which the logic operations are activated. Two of the footholds represent input-recognition strands, and these are blocked by complementary nucleic acids, whereas the other two footholds are blocked by nucleic acids that include the horseradish peroxidase (HRP)-mimicking DNAzyme sequence. The logic gates are activated by either nucleic acid inputs that hybridize to the respective "footholds", or by low-molecular-weight inputs (adenosine monophosphate or cocaine) that yield the respective aptamer-substrate complexes. This results in the respective translocation of the blocking nucleic acids to the footholds carrying the HRP-mimicking DNAzyme sequence, and the concomitant release of the respective DNAzyme. The released product-strands then self-assemble into the hemin/G-quadruplex-HRP-mimicking DNAzyme that biocatalyzes the formation of a colored product and provides an output signal for the different logic gates. The principle of the logic operation is, then, implemented as a possible paradigm for future nanomedicine. The nucleic acid inputs that bind to the blocked footholds result in the translocation of the blocking nucleic acids to the respective footholds carrying the antithrombin aptamer. The released aptamer inhibits, then, the hydrolytic activity of thrombin. The system demonstrates the regulation of a biocatalytic reaction by a translator system activated on a DNA scaffold.
[Diagnosis and treatment of diabetes mellitus-recent advances]. (1989)

In 1982, two years after the second report of the WHO Expert Committee on Diabetes Mellitus, new diagnostic criteria for diabetes mellitus were recommended by the Japan Diabetes Society and widely used in Japan. In the assessment of diabetic control, a blood ketone body measurement kit was developed and has been used for detecting its metabolic abnormality. Glycated hemoglobin has been introduced to clinical practice as an index of the past 1-2 months' diabetic control, fructosamine of the past 1-2 weeks' diabetic control and they are effectively used to achieve the good metabolic control. In the field of treatment, the extrapancreatic action of the sulfonylurea agent has been re-estimated and combination therapy with insulin is now being tested. In insulin treatment, conventional insulin injection (once a day) was not sufficient for preventing the chronic vascular complication of diabetes and intensive insulin therapy has been strongly recommended and is gradually coming into wide use. Since the development of an insulin injection pump, we have been able to mimic the normal insulin secretion pattern. With the increase of blood glucose self-monitoring, the sliding scale method can be used where the patient himself adjusts the insulin dose under certain circumstances.
Characterization of mesenchymal stem cells and fibrochondrocytes in three-dimensional co-culture: analysis of cell shape, matrix production, and mechanical performance (2016)

MSCs shift to a FCC morphology in both mono- and co-culture. Co-culture reduced hypertrophy by MSCs, indicated by collagen type X. This study shows that MSC phenotype can be influenced by indirect homogeneous cell culture in a three-dimensional gel, demonstrating the applicability of MSCs in meniscus tissue engineering applications.
Separation of blended data by iterative estimation and subtraction of blending interference noise (2011)

Abstract Seismic acquisition is a trade-off between economy and quality. In conventional acquisition the time intervals between successive records are large enough to avoid interference in time. To obtain an efficient survey, the spatial source sampling is therefore often (too) large. However, in blending, or simultaneous acquisition, temporal overlap between shot records is allowed. This additional degree of freedom in survey design significantly improves the quality or the economics or both. Deblending is the procedure of recovering the data as if they were acquired in the conventional, unblended way. A simple least-squares procedure, however, does not remove the interference due to other sources, or blending noise. Fortunately, the character of this noise is different in different domains, e.g., it is coherent in the common source domain, but incoherent in the common receiver domain. This property is used to obtain a considerable improvement. We propose to estimate the blending noise and subtract it from the blended data. The estimate does not need to be perfect because our procedure is iterative. Starting with the least-squares deblended data, the estimate of the blending noise is obtained via the following steps: sort the data to a domain where the blending noise is incoherent; apply a noise suppression filter; apply a threshold to remove the remaining noise, ending up with (part of) the signal; compute an estimate of the blending noise from this signal. At each iteration, the threshold can be lowered and more of the signal is recovered. Promising results were obtained with a simple implementation of this method for both impulsive and vibratory sources. Undoubtedly, in the future algorithms will be developed for the direct processing of blended data. However, currently a high-quality deblending procedure is an important step allowing the application of contemporary processing flows.
Digital workflow management (2000)

This paper describes the development of a set of workflow management tools (WMS) that will reduce the manual input necessary to manage the workflow of large-scale digitization projects.
Acute Kidney Injury (2010)

Acute kidney injury (AKI) is a common disease in the acutely ill patient population, as a singular diagnosis or a complication of sepsis, causing significant mortality and morbidity. Progress in diagnosis, treatment, and research in AKI has been limited by the lack of a universally accepted clinical definition. The clinical definition of AKI onset and progression, early diagnostic indicators, and understanding the unique pathophysiology of AKI are requisite to early treatment and management and ultimately positive patient outcomes. This article reviews the advances in defining and staging AKI on the basis of international consensus statements. An update on the most recent concepts affecting renal pathophysiology in AKI is also presented. Current clinical tools used in diagnosing and monitoring AKI, including the development of renal biomarkers, are discussed.
Extracorporeal Perfusion Treatment with Immobilized L‐Asparaginase (1977)

2 female patients with malignant melanoma were treated with L-asparaginase immobilized in an extra-corporeal perfusion chamber constructed by Hydén et al. The patients were treated for 80 h during 26 d and for 99 h during 36 d, respectively. L-asparaginase was immobilized by covalent bonds on the surfaces of the chamber. Perfusion resulted in an effective decrease down to less than 7 mmol/1 serum of the asparagine content. The patients withstood the treatments well without any signs of allergic reactions. Antibodies against L-asparaginase were not found. Analyses were continuously performed during the treatment with respect to electrolytes, enzymes and immunoglobulins. No abnormal variations could be found.
A fast on-board integrated battery charger for four-motor EVs (2014)

A novel type of fast on-board battery charger, applicable for four-motor electric vehicles (EVs), is presented in the paper. The charger consists exclusively of components that are already present on-board the vehicle. Having no new elements, it has a positive impact on the cost, weight and space saving in the vehicle. A three-phase grid is directly attached to the neutral points of three propulsion machines, so that hardware reconfiguration with respect to the propulsion mode of operation is not required. The charger operates with unity power factor and both charging and vehicle-to-grid (V2G) modes are feasible. The torque is not produced in the machines during the charging/V2G process. The charger is particularly suited for the interleaving process, which is used to improve the quality of the current that is taken/injected into the grid. A complete control algorithm for the charging/V2G operation is given, and performance of the charger, including torque-free operation feature, is validated by simulations.
A Single-Feeding Port HF-UHF Dual-Band RFID Tag Antenna (2017)

Radio-frequency identification (RFID) is an emerging technology and is one of the most rapidly growing segments of today's automatic identification and data collection industry High frequency (HF) and ultra-high frequency (UHF) bands have many advantages over other bands that are frequently used in RFID. In terms of operating frequency bands, HF bands are widely applied in short-distance reading applications because they provide improved security and greater information storage capability because of their near-field operation. UHF bands offer better speed and are often applied in long-distance reading applications In some special cases, such as logistics, inventtory management and bioengineering, both short-and longdistance reading are needed. Therefore, a single RFID antenna with a dual operating frequency band is required. Combining both RFID standards on the same tag would increase this an-tenna's capabilities and could lead to new applications. However, the use of two chips for two bands would increase the cost of the tag. In this paper, a single-feeding port for an application specific integrated circuit (ASIC) mono-chip is used for the dual-band RFID tag antenna.
A new lanthanum titanium oxysulfide, La16Ti5S17+xO17, withx = 0.75 (9) (2003)

The title compound, hexadecalanthanum pentatitanium heptadecasulfide heptadecaoxide, La(16)Ti(5)S(17+x)O(17) [x = 0.75 (9)], has been obtained as a by-product in the preparation of new oxychalcogenide compounds in the La/Ti/Ag/S/O system. La(16)Ti(5)S(17+x)O(17) crystallizes in the tetragonal system (space group I4/m) and is isostructural with Nd(16)Ti(5)S(17)O(17). The structure of the title compound consists of an [La(2)S(2)] rock-salt-type framework, which delimits [001] square channels containing two types of chains of corner-sharing Ti(O,S)(6) octahedra. These chains are connected through La(O,S)(n) polyhedra.
Unanticipated Difficult Airway Management in the Prehospital Emergency Setting (2010)

Adherence to a simple algorithm using GEB, ILMA, and cricothyroidotomy solved all difficult intubation cases occurring in a prehospital emergency setting.