gebhart/patrepeval huggingface dataset:
A thin-film diode strain sensor (1968)

A new type of thin-film strain sensor has been conceived. This sensor is a p-n heterojunction diode utilizing polycrystalline semiconductor layers obtained by vacuum evaporation onto an insulating substrate. The device exhibits large shifts in its forward I-V characteristic when subjected to a mechanical strain, and thus functions as a low output impedance voltage source.
Paxillin controls directional cell motility in response to physical cues (2012)

Physical cues from the extracellular environment that influence cell shape and directional migration are transduced into changes in cytoskeletal organization and biochemistry through integrin-based cell adhesions to extracellular matrix (ECM). Paxillin is a focal adhesion (FA) scaffold protein that mediates integrin anchorage to the cytoskeleton, and has been implicated in regulation of FA assembly and cell migration. To determine whether paxillin is involved in coupling mechanical distortion with directional movement, cell shape was physically constrained by culturing cells on square-shaped fibronectin-coated adhesive islands surrounded by non-adhesive barrier regions that were created with a microcontact printing technique. Square-shaped cells preferentially formed FAs and extended lamellipodia from their corner regions when stimulated with PDGF, and loss of paxillin resulted in loss of this polarized response. Selective expression of the N- and C-terminal domains of paxillin produced opposite, but complementary, effects on suppressing or promoting lamellipodia formation in different regions of square cells, which corresponded to directional motility defects in vitro. Paxillin loss or mutation was also shown to affect the formation of circular dorsal ruffles, and this corresponded to changes in cell invasive behavior in 3D. This commentary addresses the implications of these findings in terms of how a multifunctional FA scaffold protein can link physical cues to cell adhesion, protrusion and membrane trafficking so as to control directional migration in 2D and 3D. We also discuss how microengineered ECM islands and in vivo model systems can be used to further elucidate the functions of paxillin in directional migration.
Erythrocyte membrane fluidity and haemoglobin haemoporphyrin conformation: features revealed in patients with heart failure (2005)

This study examined the possible involvement of abnormal erythrocyte oxygen (O(2)) transport in the pathogenesis of heart failure. Haemoglobin (Hb) haemoporphyrin conformation was assessed by Raman spectroscopy (RS) of blood samples, whereas membrane fluidity was estimated at depths of 0.6-0.8 and 2.2nm by electron-paramagnetic resonance spectroscopy of erythrocytes loaded with spin-labeled 5-doxylstearic acid and 16-doxylstearic acid, respectively. The fluidity of erythrocyte membranes from patients with heart failure was decreased in the area near the membrane surface and remained unchanged in the deeper hydrophobic membrane regions. The same differences were also detected in healthy controls subjected to chronic high-altitude hypoxia. RS demonstrated that in heart failure the total content of Hb-ligand complexes and the relative content of Hb-nitric oxide (NO) complexes with cleaved Fe(2+)-globin bond was decreased, whereas content of Hb-NO complexes with preserved Fe(2+)-globin bond was increased. We propose that this phenomenon contributes to the reduced O(2) tissue supply seen in patients with heart failure.
Direct Decay from the Superdeformed Band to the Yrast Line in D66152y86 (2002)

The excitation energy, spin, and parity of the yrast superdeformed band in 152Dy have been firmly established. The evidence comes mainly from the measured properties of a 4011 keV single-step transition connecting the yrast superdeformed level fed by the 693 keV transition to the 27- yrast state. Four additional, weaker, linking gamma rays have been placed as well. The excitation energy of the lowest superdeformed band member is 10 644 keV and its spin and parity are determined to be 24+.
How climate change will affect sessile stages of brown trout (Salmo trutta) in mountain streams of the Iberian Peninsula (2017)

This study is aimed at quantitatively predicting thermal and physical habitat loss for the sessile stages of brown trout life cycle due to clime change, in mountain streams at the rear edge of the species natural distribution using high-resolution spatial-temporal simulations of the thermal and physical habitat. Status: Accepted presentation
Phase II study of nimotuzumab combination with paclitaxel and cisplatin as the first-line treatment in patients with local advanced or metastatic esophageal squamous cell cancer (ESCC): An interim analysis. (2012)

e14604 Background: Nimotuzumab is a genetically engineered humanized antibody (mAb) that recognizes an epitope located in the extracellular domain of human EGFR. Evidences have shown that nimotuzumab is effective and safe in SCCHN. The combination of paclitaxel/cisplatin (TP) is a standard regimen for advanced or metastatic ESCC. This open uncontrolled phase II study was designed to determine the efficacy and safety of nimotuzumab in combination with TP as the first-line treatment in advanced ESCC. Methods: All patients have histology/cytology confirmed advanced or metastatic ESCC with ECOG PS 0-2. The treatment plan is as the following: paclitaxel administered intravenously (IV) 175 mg/m2 on d1 and cisplatin IV 30-35mg/ m2/d on d1-2, every 21 days for 6 cycles, and nimotuzumab IV 200mg weekly. For patients with stable disease (SD) and better, nimotuzumab will be given continuously after 6 cycles of TP. The primary endpoint is objective response rate (RR) with 56 patients enrollment (target RR &gt;60%); secondary endpoints were progression-free survival (PFS), overall survival (OS) and safety/ tolerability. The coordinations between EGFR and ERCC1 with response of treatment will be analyzed. Results: Up to date, 25 patients (male/female, 20/5; median age 58) have been enrolled. All patients were evaluated for toxicity and 22 are evaluable for response. 14 (63.6%) had a confirmed partial response (PR) and 7 (31.8%) had SD as their best responses with disease control rate of 95.4%. Only one patient had progressive disease (PD). Grade 3 or 4 neutropenia, neutropenic fever and anemia occurred in 52.2%, 4% and 13% respectively. Nonhematological toxicities were generally mild with grade 1 or 2 alopecie, hypodynamia, anorexia, nausea, arthralgia, and itch of skin occurring in 80%, 60.9%, 43.5%, 34.8%, 30.4%, and 21.7%. One patient had a grade 3 haematuria. Conclusions: The interim analysis showed that the combination of nimotuzumab with TP is tolerated reasonably well in patients with advanced or metastatic ESCC and encouraging efficacy. The study is ongoing with coordination of biomarkers and response as well.
Experimental analysis on AC loss and fault current test of HTS coils co-wound with various inserted materials (2016)

A significant number of recent studies have explored the impact of many kinds of winding insulation conditions on high-temperature superconducting (HTS) coils for the application of electric devices. HTS coil co-wound with turn-to-turn inserted materials could be an appropriate alternative to the no-insulation coil because of the poor charge-discharge delay and unexpected quench behavior of the no-insulation coil. In addition, the co-wound HTS coil has good thermal stability and mechanical integrity, making it useful for superconducting applications such as superconducting magnetic energy storage (SMES) and superconducting fault current limiter (SFCL). However, studies of the co-wound HTS coil have explored dc electrical characteristics, but not ac electrical characteristics. Research into ac electrical characteristics is essential because of the operation sequence of the SMES and fault occurrence for the SFCL. In this paper, the ac electrical characteristics of HTS coils co-wound with various inserted materials were experimentally analyzed. Tested coils were co-wound with either Kapton, stainless steel, or copper tape at every turn of the winding, and one no-insulation coil served as a reference. AC loss, fault current, and recovery time were measured at 77 K, self-field.
Unified Lateral Motion Control Of Vehicles For Lane Change Maneuvers In Automated Highway Systems (1997)

This report deals with the lateral guidance of vehicles, with focus on lane change maneuvers. Two approaches are presented for lane changes maneuvers. The first is to treat the maneuvers as a tracking control problem. A virtual desired trajectory (VDT) is used a tracking control approach. The second is to use a unified lateral guidance algorithm which consists of the desired yaw rate generator and the yaw rate tracking controller.
The HDAC Inhibitor Quisinostat (JNJ-26481585) Supresses Hepatocellular Carcinoma alone and Synergistically in Combination with Sorafenib by G0/G1 phase arrest and Apoptosis induction (2018)

The high activity of Histone deacetylases (HDACs) in hepatocellular carcinoma (HCC) usually positively correlates with poor prognosis of patients. Accordingly histone deacetylases inhibitors (HDACis) are considered to be potential agents treating patients with HCC. In our study, we evaluated effect of quisinostat alone and in combination with sorafenib in HCC cells via inducing G0/G1 phase arrest through PI3K/AKT/p21 pathway and apoptosis by JNK/c-Jun/caspase3 pathway <i>in vitro</i> and <i>in vivo.</i> The proliferation assay and flow cytometry were used to measure the viability, cell cycle and apoptosis. And Western blot assay was carried out to determine expression alternations of related proteins. Moreover HCCLM3 xenograft was further performed to detect antitumor effect of quisinostat <i>in vivo</i>. Here, we found that quisinostat impeded cell proliferation, and remarkably induced G0/G1 phase arrest and apoptosis in HCC cells in a dose-dependent manner. G0/G1 phase arrest was observed by alterations in PI3K/AKT/p21 proteins. Meanwhile the JNK, c-jun and caspase-3 were activated by quisinostat in a dose-dependent manner. Correspondingly quisinostat facilitated G0/G1 cycle arrest and apoptosis in HCC cells through PI3K/AKT/p21 pathways and JNK/c- jun/caspase3 pathways. Moreover, the potent tumor-suppressive effects facilitated by quisinostat, was significantly potentiated by combination with sorafenib <i>in vitro</i> and <i>vivo</i>. The combination treatment of quisinostat and sorafenib markedly suppressed cell proliferation and induced apoptosis in a synergistic manner. Moreover the therapy of quisinostat combined with sorafenib could apparently decrease tumor volume of a HCCLM3 xenograft model. Our study indicated that quisinostat, as a novel chemotherapy for HCC, exhibited excellent antitumor activity <i>in vitro</i> and <i>vivo</i>, which was even enhanced by the addition of sorafenib, implying combination of quisinostat with sorafenib a promising and alternative therapy for patients with advanced hepatocellular carcinoma.
Electron and Ambipolar Transport in Organic Field-Effect Transistors (2007)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectron and Ambipolar Transport in Organic Field-Effect TransistorsJana Zaumseil and Henning SirringhausView Author Information Cavendish Laboratory, JJ Thomson Avenue, Cambridge CB3 0HE, United Kingdom Cite this: Chem. Rev. 2007, 107, 4, 1296–1323Publication Date (Web):March 23, 2007Publication History Received31 July 2006Published online23 March 2007Published inissue 1 April 2007https://pubs.acs.org/doi/10.1021/cr0501543https://doi.org/10.1021/cr0501543research-articleACS PublicationsCopyright © 2007 American Chemical SocietyRequest reuse permissionsArticle Views29792Altmetric-Citations1958LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Charge transport,Electrodes,Insulators,Polarity,Transistors Get e-Alerts
Organic rankine cycle part-load characterization: validated models of an 11 kWe waste heat recovery ORC (2016)

The organic Rankine cycle (ORC) is a mature technology for converting low temperature heat to electricity. However before large scale adoption in waste heat recovery applications is attained companies need to be convinced of the benefits. Considering the appraisal of an ORC project is mainly motivated by the financial gain, an accurate prediction of the power output is essential. Yet, when considering waste heat valorisation, the majority of applications have time varying waste heat streams. As such detailed models are necessary to account for part-load operation. This work aims to develop robust and computationally effective part-load models for ORCs. Important is that these models are thoroughly validated based on experimental results from a scaled down 11 kWe waste heat recovery ORC. Special attention has been paid in detecting stable experimental steady state data points for validation. The validated model presented is able to accurately predict the net power output within ±2%.
Transformation of Polymerization Sites into Hydrogen Dissociation Sites on Propylene Polymerization Catalyst Induced by the Reaction with Al-Alkyl Cocatalyst (2005)

Hydrogen (H2) is the most important chain-transfer agent to control the molecular weight (MW) of polymer in all industrial processes using Ziegler−Natta catalysts. However, the specific mechanism of chain-transfer reaction by H2 is still open for discussion. Stopped-flow techniques were utilized to investigate the chain-transfer mechanism by H2 on TiCl4/EB/MgCl2 catalyst pretreated by triethylaluminum (TEA) cocatalyst within an ultrashort time (0−1.1 s). First, the results obtained in the absence of H2 demonstrated the first experimental evidence of plausible guard effect on the active sites by coordinating growing polymer chain in the initial stage of propylene polymerization. A gradual decrease of active sites concentration, increase of chain propagation rate constant and isospecificity of active sites were observed even after an ultrashort period pretreatment due to the preferential deactivation of aspecific sites, which was found not to be affected by the presence of H2. On the other hand, H2 could not decrease the MW of polymer except using catalyst with pretreatment. Moreover, the MW is gradually decreased with increase of pretreatment time and the extent of MW decrease was enhanced with the increase of pretreatment time suggesting that deactivation of polymerization sites could be associated with the formation of H2 dissociation sites for chain transfer. This was subsequently confirmed by H2−D2 exchange reaction combined with simultaneous pretreatment of the catalyst with TEA, which indicates a plausible transformation of polymerization sites into H2 dissociation sites for chain transfer on Ziegler−Natta catalysts induced by interaction with Al-alkyl cocatalyst.
Cadherin switching during the formation and differentiation of the Drosophila mesoderm – implications for epithelial-to-mesenchymal transitions (2014)

ABSTRACT Epithelial-to-mesenchymal transition (EMT) is typically accompanied by downregulation of epithelial (E-) cadherin, and is often additionally accompanied by upregulation of a mesenchymal or neuronal (N-) cadherin. Snail represses transcription of the E-cadherin gene both during normal development and during tumour spreading. The formation of the mesodermal germ layer in Drosophila , considered a paradigm of a developmental EMT, is associated with Snail-mediated repression of E-cadherin and the upregulation of N-cadherin. By using genetic manipulation to remove or overexpress the cadherins, we show here that the complementarity of cadherin expression is not necessary for the segregation or the dispersal of the mesodermal germ layer in Drosophila . However, we discover different effects of E- and N-cadherin on the differentiation of subsets of mesodermal derivatives, which depend on Wingless signalling from the ectoderm, indicating differing abilities of E- and N-cadherin to bind to and sequester the common junctional and signalling effector β-catenin. These results suggest that the downregulation of E-cadherin in the mesoderm might be required to facilitate optimal levels of Wingless signalling.
[Mycoplasma infection in human gastriointestinal carcinoma tissues]. (2001)

The high infection of mycoplasmas in carcinoma tissues suggest an association between mycoplasma and cancer. The mechanism involved in oncogenesis by mycoplasmas remains to be elucidated.
SOCIO-ECONOMIC IMPLICATIONS OF MICRO CREDIT ON ECONOMIC DEVELOPMENT OF RURAL WOMEN IN NIGERIA (2015)

The study was undertaken to analyze the implications of micro credit experiences on rural women’s economic development. In general, rural development through women participation is the most important strategy designed to improve the social and economic life of the farming community in Nigeria, because their economic contribution is substantial (Izugbara, 2004). However, Parveen &amp;amp; Chaudhury (2009) argued that traditional labor division places on women, the primary responsibility of domestic chores as cooking, childcare, cleaning and fetching of water, amongst others. Invariably, women have limited access to markets, education; health care and economic services, which has led to a lower well-being of the family, which in-turn is believed to have retarded the developmental and traumatized the goals of the state. Put succinctly, micro credit is a system of small loans for incoming-generating activities, which enable poor communities to gain some economic stability (Chavan &amp;amp; Ramakumar, 2002). This paper seeks the historical relationship between micro credit programmes and economic hardship elimination of women, as it enhances their development in Otan-Ayegbaju, Boluwaduro local Government Area of Osun State. Ten in-depth interviews and 40 self-administered questionnaires were distributed to the participants of Better Life for Rural Women Programme in order to collect data. The paper argued that the context for understanding the position of micro credit based on the in-depth interviews support that the programmes should equally be extended to male folk. Recommendation and suggestions are given that if the micro credit programmes are strengthened it would involve male participation.
Antitumor activity and mechanism of action of the novel marine natural products mycalamide-A and -B and onnamide. (1989)

Three novel heterocyclic compounds, mycalamide-A and -B and onnamide, were isolated from Mycale sp. and Theonella sp. sponges collected in New Zealand and Okinawan waters. Each exhibited potent in vitro toxicity and in vivo efficacy against murine and human tumor cells. Concentrations of each that inhibited replication of cultured murine lymphoma P388 cells by 50% were 5 nM or less. Mycalamide-A and -B were also potent inhibitors of HL-60, HT-29, and A549 human tumor cell replication (50% inhibitory concentration less than 5 nM), while values for onnamide were greater (50% inhibitory concentrations between 25 and 200 nM). Mycalamide-A (10 micrograms/kg) and -B (2.5 micrograms/kg) were moderately active against P388 leukemia (increase in life span, approximately 50%), while onnamide was inactive (40 micrograms/kg; increase in life span, 15%). Mycalamide-A was also active against B16 melanoma, Lewis lung carcinoma, M5076 ovarian sarcoma, colon 26 carcinoma, and the human MX-1, CX-1, and Burkitt's lymphoma tumor xenografts. Mechanism of action studies indicate that the three agents inhibited protein synthesis. For example, after 1-h exposures to 20 nM mycalamide-A and -B, the rates of [3H]leucine incorporation into acid-precipitable material of cultured P388 cells were inhibited 54 and 99%, while the effects on incorporation of [3H]uridine and [3H]thymidine were less. The relative effects of 20 to 2000 nM mycalamide-A on protein, RNA, and DNA synthesis were consistent with those observed during exposure of P388 cells to 1 microM emetine, a known inhibitor of protein synthesis. Also, the three agents inhibited translation of RNA into protein in a cell-free lysate of rabbit reticulocytes. Although mycalamide-A disrupted DNA metabolism, the agent apparently did not intercalate into DNA, and a mixture of four deoxynucleosides (250 microM each) did not decrease the antiproliferative effects of the agent. Collectively, these data indicate that this class of compounds represents novel antitumor agents which should be further evaluated to define their potential.
Shot noise induced by electron-nuclear spin-flip scattering in a nonequilibrium quantum wire (2012)

We study the shot noise (nonequilibrium current fluctuation) associated with dynamic nuclear polarization in a nonequilibrium quantum wire (QW) fabricated in a two-dimensional electron gas. We observe that the spin-polarized conductance quantization of the QW in the integer quantum Hall regime collapses when the QW is voltage biased to be driven to nonequilibrium. By measuring the shot noise, we prove that the spin polarization of electrons in the QW is reduced to $\ensuremath{\sim}$$0.7$ instead of unity as a result of electron-nuclear spin-flip scattering. The result is supported by Knight shift measurements of the QW using resistively detected NMR.
Overview of molecular target-based drugs (2006)

がんの生物学の発展により発がん・悪性化に関わるさまざまな遺伝子産物が解明されつつある. これに伴い抗がん剤の分子標的をあらかじめ選定したうえで薬を開発すること, すなわち分子標的治療薬の開発が可能となった. 分子標的治療薬は, がんのアキレス腱といえるような特徴的分子を狙おうとするもので, がんへの選択毒性が高く, したがって副作用が低いことが期待される. チロシンキナーゼ阻害剤に端を発した分子標的薬剤の開発は, ハーセプチン, グリベックなどの成功によりその方向性に間違いのないことが実証された. 分子標的治療薬の実用化によりがんの薬物療法は新たな時代を迎えた.本稿では, 近年承認された, あるいは現在開発中の分子標的治療薬について概観する.
Core-scale description of porous media dissolution during acid injection - part II: calculation of the effective properties (2006)

Acid injection in porous medium is a process widely used for stimulation of petroleum wells and leads to the formation of highly conductive channels called wormholes. Two different transport-reaction models have been developed in Part I to describe the phenomenon at the core-scale. The possible existence of core-scale effective properties which appear in these models is discussed here on the basis of Darcy-scale numerical experiments. The advantages and drawbacks of one-equation and two-equation models are investigated by reference to averaged fields computed from Darcy-scale simulations.