gebhart/patrepeval huggingface dataset:
Lipid functions in skin: Differential effects of n-3 polyunsaturated fatty acids on cutaneous ceramides, in a human skin organ culture model (2017)

Ceramides are important for skin health, with a multitude of species found in both dermis and epidermis. The epidermis contains linoleic acid-Ester-linked Omega-hydroxylated ceramides of 6-Hydroxy-sphingosine, Sphingosine and Phytosphingosine bases (CER[EOH], CER[EOS] and CER[EOP], respectively), that are crucial for the formation of the epidermal barrier, conferring protection from environmental factors and preventing trans-epidermal water loss. Furthermore, a large number of ceramides, derivatives of the same sphingoid bases and various fatty acids, are produced by dermal and epidermal cells and perform signalling roles in cell functions ranging from differentiation to apoptosis. Supplementation with the n-3 polyunsaturated fatty acids (PUFA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have shown promise as therapeutic agents in a number of inflammatory skin conditions, altering the lipid profile of the skin and production of bioactive lipids such as the eicosanoids, docosanoids and endocannabinoids. In this study we wished to investigate whether EPA and DHA could also affect the ceramide profile in epidermis and dermis, and, in this way, contribute to formation of a robust lipid barrier and ceramide-mediated regulation of skin functions. Ex vivo skin explants were cultured for 6days, and supplemented with EPA or DHA (50μM). Liquid chromatography coupled to tandem mass spectrometry with electrospray ionisation was used to assess the prevalence of 321 individual ceramide species, and a number of sphingoid bases, phosphorylated sphingoid bases, and phosphorylated ceramides, within the dermis and epidermis. EPA augmented dermal production of members of the ceramide families containing Non-hydroxy fatty acids and Sphingosine or Dihydrosphingosine bases (CER[NS] and CER[NDS], respectively), while epidermal CER[EOH], CER[EOS] and CER[EOP] ceramides were not affected. DHA did not significantly affect ceramide production. Ceramide-1-phosphate levels in the epidermis, but not the dermis, increased in response to EPA, but not DHA. This ex vivo study shows that dietary supplementation with EPA has the potential to alter the ceramide profile of the skin, and this may contribute to its anti-inflammatory profile. This has implications for formation of the epidermal lipid barrier, and signalling pathways within the skin mediated by ceramides and other sphingolipid species. This article is part of a Special Issue entitled: Membrane Lipid Therapy: Drugs Targeting Biomembranes edited by Pablo V. Escribá.
The Hybrid Progress Note (2012)

Health care institutions are moving toward fully functional electronic medical records (EMRs) that promise improved documentation, safety, and quality of care. However, many hospitals do not yet use electronic documentation. Paper charting, including writing daily progress notes, is time-consuming and error prone. To improve the quality of documentation at their hospital, the authors introduced a highly formatted paper note template (hybrid note) that is prepopulated with data from the EMR. Inclusion of vital signs and active medications improved from 75.5% and 60% to 100% (P < .001), respectively. The use of unapproved abbreviations in the medication list decreased from 13.3% to 0% (P < .001). Prepopulating data enhances provider efficiency. Interviews of key clinician leaders also suggest that the initiative is well accepted and that documentation quality is enhanced. The hybrid progress note improves documentation and provider efficiency, promotes quality care, and initiates the development of the forthcoming electronic progress note.
Dual detection for optical code division multiple access communication (2004)

A dual optical detection scheme is proposed for optical code division multiple-access systems utilizing on-off-keying modulation technique. The proposed detector is developed by combining a correlation detector and a chip-level detector with the logical OR operation. In this way, the merits of two detectors can be fully exploited. Thus the dual detector can achieve the enhanced bit error rate performance in the presence of both multi-user interference and noise.
Transconductance enhancement mechanisms in ultra-thin (<or=1000 A) silicon-on-insulator MOSFETs (1988)

Two advantages of ultrathin (<or=1000 AA) silicon-on-insulator (SOI) films for MOSFETs that have not previously been reported are described. Compared to bulk FETs of similar dimensions are doping levels, the effects have been observed to give up to 35% increase in drain saturation current or transconductance. Both experimental data and modeling are discussed. It is noted that the kink effect is absent in the ultrathin-film SOI FETs, and that the results were adjusted to account for the difference in threshold voltage in the n-channel bulk and ultrathin-film structures. In general, an increase in saturation current should lead to faster circuits. The experiments and modeling results to date are for long-channel structures only.<<ETX>>
Effects of displaced p-n junction of heterojunction bipolar transistors (1992)

Two-dimensional simulations that demonstrate the effects of displacements of the p-n junctions from the heterojunctions of symmetrical Al/sub 0.28/Ga/sub 0.72//GaAs double-heterojunction bipolar transistors (DHBTs) are reported. When the emitter and/or collector p-n junctions do not coincide with the AlGaAs/GaAs heterojunctions, the electrical characteristics are shown to be drastically altered due to changes in the potential profiles and to changes in recombination rates both in the neutral base and in the space-charge region of the emitter. The effects of a small displacement of the p-n junction from the emitter-base or the base-collector heterojunctions are examined and results for current gain beta and cutoff frequency f/sub T/ are given that demonstrate enhanced performance for DHBTs with p-n junctions that are not coincident with the heterojunctions.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Analysis of K-league data using bivariate Poisson and diagonal inflated model (2018)

축구경기의 특점수 분석을 위한 연구는 꾸준히 이루어져 왔다 (Seong과 Chang, 2007; Lee, 2012). 본 연구는 2015~2018년의 케이-리그(K-league) 경기 결과 자료에 이변량 영과잉 포아송 회귀모형을 포함한 8개의 회귀모형을 적합하였다. 반응변수는 홈팀과 원정팀의 전체 득점수 또는 후반전 득점수이며 설명변수는 각 팀의 전반전 득점수, 전반전 점유율이다. 모형판정기준에 의해 가장 적절한 모형은 전반적 득점수, 전반전 점유율을 설명변수로 한 이변량 포아송 회귀모형과 동점발생확률에 대해 포아송 분포를 적용한 대각확대 회귀모형으로 나타났다. 홈팀의 전체 득점수에 대해 전반전 득점수가 점유율보다 높은 영향력을 미치는 반면 원정팀의 전체 득점수에 대해 전반전 득점수보다 전반전 점유율이 높은 영향력을 미침을 알 수 있었다.
High-efficiency semiconductor resonant-cavity light-emitting diodes: a review (2002)

An overview of highly efficient resonant-cavity light-emitting diodes is presented. First, the basics of dipole emission in planar cavities are reviewed. From these, a number of design rules are derived. We point out some guidelines for comparison of high-efficiency light-emitting diodes, and use these to review the state-of-the-art devices in different material systems and at different wavelengths. We also discuss some advanced techniques based on gratings or photonic crystals to improve the efficiency of these devices.
Photo-induced refractive index change in hydrogenated amorphous silicon oxynitride (2002)

Refractive index change is shown to be induced by the irradiation of ultraviolet photons in hydrogenated amorphous silicon oxynitride films prepared by plasma-enhanced chemical vapor deposition. The mechanism of the index change and its dependence on the nitrogen content were investigated by electron spin resonance and scanning electron microscopy. It is concluded that the index change is due mainly to densification, and that the contribution of the formation of paramagnetic defects is only slight. To demonstrate the versatility of this refractive index change, a planar diffraction grating was fabricated.
Micropropagation of Ornamental Plant Musa Beccarii through Tissue Culture Technique Using Suckers and Male Buds as Explants (2012)

Abstract: Musa beccarii is grouped under wild bananas and endemic in Borneo. This ornamental plant is among the most unique ornamental bananas that produce colorful and attractive flowers with small plant compared to the cultivated bananas for fruits. Micropropagation is a laboratory based tissue culture technique commonly used to propagate any plants. Micropropagation studies of these species have become important in order to increase the productivity for mass propagation in floriculture industry. This study was conducted to observe and determine the optimum sterilization procedure and media requirement for the regeneration of explants using in vitro method. Sterilization procedure for both suckers and male buds inflorescence for this ornamental banana were almost the same, whereas for suckers, 100 % Clorox with tween 20 and 70 % ethanol were used and for male buds, 70 % ethanol was only used. It is found out that prolific multiple shoot formation and elongation were obtained from the suckers and male flower buds cultured on MS basal medium with 0.014mg/L BAP. Charcoal, coconut water, and gelrite (agar) were also added into the medium and PH was adjusted to 5.8. Unfortunately, the final phase was not able to perform as the plantlets were died after 5 weeks transplanting from media culture to the soil. It might be because of the sunlight that was too hot or the plant could not acclimatize to the new condition. So, the plantlets were not
Poly(lactic acid) nanoparticles of the lead anticancer ruthenium compound KP1019 and its surfactant-mediated activation (2013)

Nanoparticle formulations offer besides the advantage of passive drug targeting also the opportunity to increase the stability of drugs. KP1019 is a lead ruthenium(III) compound which has been successfully tested in a clinical phase I trial. However, it is characterized by low stability in aqueous solution especially at physiological pH. To overcome this limitation, poly(lactic acid) (PLA) nanoparticles of KP1019 with two different surfactants (Pluronic F68 and Tween 80) were prepared by a single oil-in-water (o/w) emulsion. Cytotoxicity measurements comparing different aged Tween 80 nanoparticles revealed that the color change from brown to green was associated with an up to 20 fold increased activity compared to "free" KP1019. Further investigations suggested that this is based on the formation of enhanced intracellular reactive oxygen species levels. Additional studies revealed that the origin of the green color is a reaction between KP1019 and Tween 80. Kinetic studies of this reaction mixture using UV-Vis, ESI-MS and ESR spectroscopy indicated on the one hand a coordination of Tween 80 to KP1019, and on the other hand, the color change was found to correlate with a reduction of the Ru(III) center by the surfactant. Together, the results provide a first experimental approach to stabilize a biologically active Ru(II) species of KP1019 in aqueous solution, which probably can be also used to selectively generate this activated species in the tumor tissue via delivery of KP1019 using Tween 80 nanoparticles.
Design and analysis of a newly brushless DC wind generator (2008)

This paper aims to the disadvantage of high adjustment rate and many ripples for PM synchronous generator in wind power generation system, presents a newly brushless dc wind generator, whose rotor adopts tangential structure and Ferrite material in permanent magnet to increase flux, and the stator is composed of Single-wave winding structure connected polyphase full wave non-controlled rectification bridge. The paper emphasizes on discussing the internal structure design and magnetic field analysis of the generator. A experiment is completed to compare the prototype with PM synchronous generator. the experimental results have confirmed the effectiveness and feasibility of the design.
An industry‐oriented strategy for the finite element simulation of paperboard creasing and folding (2017)

The numerical simulation of paperboard creasing and folding processes is of increasing importance for the design and production of safe and reliable packaging systems. The extreme material anisotropy and the complexity of these processes require however simulation capabilities which are seldom available in commercial codes. Several approaches have been proposed in the literature over the years, in most cases making use of non‐linear material models developed ad hoc for this purpose. These models, some of which are very effective and accurate, are not in general available in commercial codes and are often based on the definition of a large number of parameters. In this paper, the possibility to obtain acceptable, first‐hand simulation results using only features already available in a commercial code is investigated. An advanced continuum constitutive model, recently presented in the literature, has been used as a reference for tuning the model and for assessing its accuracy. It is shown how standard features, usually available in state‐of‐the‐art commercial codes, can be employed to deal with the extreme material anisotropy, obtaining qualitatively good results in both the creasing and folding phases. The used standard model accounts for the extremely high anisotropy by means of embedded shell elements, playing the role of reinforcements in the fibre direction. The matrix is assumed to be isotropic and elastoplastic, with properties determined based on the behaviour in the thickness direction. The adopted plasticity model is a modified Drucker–Prager model with a cutoff on the tensile pressure side, available in the used commercial code. The procedure adopted for the identification of the small number of required material parameters is also discussed. Copyright © 2017 John Wiley &amp; Sons, Ltd.
Confinement of photons and control of their emission using surface addressable photonic crystal membrane (2013)

High index contrast periodic structures can be exploited to perform an arbitrarily adjustable spatio-temporal molding of light at the wavelength scale. This tight control of photons is obtained through a shaping of resonant modes and a suitable adjustment of their coupling with propagative modes. In this talk, surface addressable (or above the light line) Bloch modes in photonic crystal membranes (PCMs) will be investigated. The concepts governing the properties of these modes will be first presented. It will be demonstrated that simple models can be considered to understand their behavior and, more specifically, their ability to capture photons during the desired lifetime. Bloch modes with a very large band width or a very high Q factor can be easily designed this way. The wide application range of these PCMs will be illustrated by different devices. Low Q Bloch modes will be first used as efficient and broadband reflectors and exploited to realize compact and efficient vertical cavity lasers with unprecedented functionalities. In addition, it will be shown that this kind of mirrors can be bent in order to confine photons in the 3 directions even in low index materials, opening the way to a new class of emitters and sensors. Finally, the exploitation of high Q Bloch modes to design highly directional thermal emitters with wavelength selectivity will be presented.
Mechanism and Kinetics of Acetyl-Lysine Binding to Bromodomains (2013)

Bromodomains are four-helix bundle proteins that specifically recognize acetylation of lysine side chains on histones. The available X-ray structures of bromodomain/histone tail complexes show that the conserved Asn residue in the loop between helices B and C is involved in a hydrogen bond with the acetyl-lysine side chain. Here we analyze the spontaneous binding of acetyl-lysine to the bromodomain TAF1(2) by the first molecular dynamics simulations of histone mark binding to an epigenetic reader protein. Multiple events of reversible association sampled along the unbiased simulations allow us to determine the pathway and kinetics of binding. The simulations show that acetyl-lysine has two major binding modes in TAF1(2) one of which corresponds to the available crystal structures and is stabilized by a hydrogen bond to the conserved Asn side chain. The other major binding mode is more buried than in the crystal structures and is stabilized by two hydrogen bonds with conserved residues of the loop between helices Z and A. In the more buried binding conformation, three of the six structured water molecules at the bottom of the binding pocket are displaced by the acetyl-lysine side chain. The kinetic analysis shows that the two binding modes interconvert on a faster time scale with respect to the association/dissociation process. The atomic-level description of the binding pathway and binding modes is useful for the design of small molecule modulators of histone binding to bromodomains.
Analytical techniques for conjugated linoleic acid (CLA) analysis (2001)

Interest in conjugated linoleic acid (CLA) research has increased significantly in recent years because various CLA isomers have been reported to exhibit different beneficial physiological effects in laboratory animals. These findings are detailed in the first book on this subject entitled Advances in CLA Research, Volume 1, edited by M. P. Yurawecz, M. M. Mossoba, J. K. G. Kramer, M. W. Pariza, and G. J. Nelson, and published by the American Oil Chemists Society, Champaign, Illinois, USA, in 1999. Various mixtures of CLA isomers are sold as dietary supplements today, but the biological activities observed in animal models have yet to be demonstrated in humans. Hurdles to achieving this goal include the commercial unavailability of many individual CLA isomers, and the challenge of isolating, separating and confirming the identity of low levels of CLA isomers and their metabolites in complex chemical and/or biological matrices. Therefore, there has been a critical need for analytical methodologies that can meet these difficult objectives. This dossier is about a collection of useful analytical techniques and procedures some of which are well known, while others have only recently been developed and successfully applied to CLA research. These include GC, Ag+-HPLC, RP-HPLC, GC-MS, GC-IR, and NMR.
ChemInform Abstract: Facile One‐Step Synthesis of Pyrrolidinylmethylferrocene. (1986)

Abstract Die Darstellung des Pyrrolidinylmethylferrocens (IV) gelingt durch Aminomethylierung aus Ferrocen (I), Formaldehyd (II) und Pyrrolidin (III).
Pairing on stripedt−t′−Jlattices (2009)

Results are given from a density-matrix renormalization-group study of pairing on a striped $t\text{\ensuremath{-}}{t}^{\ensuremath{'}}\text{\ensuremath{-}}J$ lattice in the presence of boundary magnetic and pair fields. We find that pairing on a stripe depends sensitively on both $J/t$ and ${t}^{\ensuremath{'}}/t$. In the strong-pairing model-parameter regime, the stripes are easily coupled by the pair field and have a uniform phase. There is a small but measurable energy cost to create antiphase superconducting domain walls.
Chemical Detection and Identification Techniques for Exobiology Flight Experiments (2002)

Thiobarbituric acid (TBA) assays which have been modified for detection of lipid hydroperoxides appear to be useful for demonstration of in vivo lipid peroxidation. Since these methods require heating tissue membranes with the buffered TBA, there is a possibility of interference from the detection of autoxidation that occurs during heating. These studies were undertaken to investigate conditions which favor TBA color production from hydroperoxide while limiting autoxidation during the assay. An acetic acid-sodium acetate buffered (pH 3.6) TBA assay was used. Heating linoleic acid hydroperoxide with 50 microM ferric iron or under nitrogen nearly doubled color production compared to heating it with no added iron or under air. The lipid antioxidant butylated hydroxytoluene inhibited color production from fatty acid hydroperoxides. When tissue fractions, including liver and lung microsomes and lung whole membranes, were heated in the assay, color production was greater under air than under nitrogen and was much greater under oxygen. When liver microsomes from carbon tetrachloride-exposed rats were used, color was increased only when oxygen was present in the heating atmosphere. The results with tissue fractions appear to demonstrate autoxidation during color development rather than the presence of preformed hydroperoxides. Finally, it was found that color production from membrane fractions was dependent on the vitamin E content of the membranes. It appears that autoxidation during heating should be limited by heating under nitrogen and not by adding antioxidants, which inhibit color production from hydroperoxides. As the vitamin E effect demonstrates, antioxidant status must be considered, since a change in color production could result from a change in antioxidant content without the accumulation of lipid hydroperoxides.
Pattern of recurrence and survival after D2 right colectomy for cancer: is there place for a routine more extended lymphadenectomy? (2022)

The absence of isolated CLM, as well as the cancer-specific OS reported in our series, support the routine use of RC-D2 for RCC. However, D3 lymphadenectomy may be recommended in selected patients, such as those with pre-operatively known CLM, or with lymph-node metastases close to the origin of the ileocolic vessels.
An Efficient Piecewise Modeling of ECG Signals Based on Hermitian Basis Functions (2007)

In this paper, a new piecewise modeling for approximation of ECG signal is presented. Most of the modeling methods are focused to obtain the best approximation of the entire ECG signal. The proposed method exploits the importance of different intervals of ECG signals, in particular QRS complex, by performing a segmented based modeling using Hermitian basis functions. This yields to weighting the approximation error of each segment based on its importance throughout the ECG complex. As the result shows the total error obtained in this method is almost halved in comparison with similar non-segmented method. This has a great impact in modeling the heart arrhythmias where a small error could mislead the diagnosis. The presented method uses only the 5th order Hermitian basis functions which considerably reduce the total parameters needed to represent the ECG signal in comparison with other Hermitian based methods.
TELEREHA - DIE BESONDEREN HERAUSFORDERUNGEN DER TELEMEDIZIN IM GERIATRISCH-REHABILITATIVEN UMFELD (2002)

Modern telecommunication technology has the potential to improve the quality of life for elders with physical and mental impairments as well as for their caregiving relatives. This can be viewed as an opportunity to establish and maintain instant and personalized access to various medical services in a situation where increasing needs are opposed to decreasing resources. However, it is not yet clear whether telematics is adequate, efficient, and effective in supporting care for geriatric patients. Results of a tele-rehabilitation project ("TeleReha", conducted at the Berlin Geriatric Center) which comprised mobility-impaired patients caregiving relatives and geriatric professionals, showed that participants regard telecommunicational and communicational needs.