gebhart/patrepeval huggingface dataset:
Epitaxial growth of TaN thin films on Si(100) and Si(111) using a TiN buffer layer (2002)

We have deposited high-quality epitaxial B1 NaCl-structured TaN films on Si(100) and Si(111) substrates with TiN as the buffer layer, using pulsed laser deposition. Our method exploits the concept of lattice-matching epitaxy between TiN and TaN and domain-matching epitaxy between TiN and silicon. X-ray diffraction, transmission electron microscopy, and scanning transmission electron microscopy (Z-contrast) experiments confirmed the single-crystalline nature of the films with cube-on-cube epitaxy. The stoichiometry of the TaN films was determined to be nitrogen deficient (TaN0.95±0.05) by Rutherford backscattering. Resistivity of the TaN films was found to be ∼220 μΩ cm at room temperature with a temperature coefficient of resistivity of −0.5 μΩ K−1.
Imputation aware tag SNP selection to improve power for multi-ethnic association studies (2017)

Abstract The emergence of very large cohorts in genomic research has facilitated a focus on genotype-imputation strategies to power rare variant association. Consequently, a new generation of genotyping arrays are being developed designed with tag single nucleotide polymorphisms (SNPs) to improve rare variant imputation. Selection of these tag SNPs poses several challenges as rare variants tend to be continentally-or even population-specific and reflect fine-scale linkage disequilibrium (LD) structure impacted by recent demographic events. To explore the landscape of tag-able variation and guide design considerations for large-cohort and biobank arrays, we developed a novel pipeline to select tag SNPs using the 26 population reference panel from Phase of the 1000 Genomes Project. We evaluate our approach using leave-one-out internal validation via standard imputation methods that allows the direct comparison of tag SNP performance by estimating the correlation of the imputed and real genotypes for each iteration of potential array sites. We show how this approach allows for an assessment of array design and performance that can take advantage of the development of deeper and more diverse sequenced reference panels. We quantify the impact of demography on tag SNP performance across populations and provide population-specific guidelines for tag SNP selection. We also examine array design strategies that target single populations versus multi-ethnic cohorts, and demonstrate a boost in performance for the latter can be obtained by prioritizing tag SNPs that contribute information across multiple populations simultaneously. Finally, we demonstrate the utility of improved array design to provide meaningful improvements in power, particularly in trans-ethnic studies. The unified framework presented will enable investigators to make informed decisions for the design of new arrays, and help empower the next phase of rare variant association for global health.
A framework for immersive VR and full-body avatar interaction (2013)

We present a new software framework for the development of immersive collaborative virtual reality applications with emphasis on full-body interaction with virtual humans. The framework is designed to be scalable and adaptable to different hardware configurations, using either commodity or more expensive hardware setups. High level programming abstractions handle object replication and communication channels for configurations based on multiple rendering nodes. The system provides tools for full-body character animation, real-time full-body tracking and retargeting to virtual humans, including motion reconstruction from a small set of sensors. Such capabilities allow new full-body interaction metaphors to be developed in fixed or user-perspective stereo visualization. The framework is scalable, customizable, cross-platform and it is only based on tools with source code available.
Biomimetic synthesis of a cyclopropane containing eicosanoid from the coral Plexaura homomalla. Assignment of relative configuration (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBiomimetic synthesis of a cyclopropane containing eicosanoid from the coral Plexaura homomalla. Assignment of relative configurationJames D. White and Mark S. JensenCite this: J. Am. Chem. Soc. 1993, 115, 7, 2970–2971Publication Date (Print):April 1, 1993Publication History Published online1 May 2002Published inissue 1 April 1993https://pubs.acs.org/doi/10.1021/ja00060a053https://doi.org/10.1021/ja00060a053research-articleACS PublicationsRequest reuse permissionsArticle Views233Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
RAPID PROTOTYPING OF SELF ALIGNED 3D MICROFLUIDIC STRUCTURES (2013)

This paper reports a cost effective and rapid prototyping technique to create self-aligned 3D microfluidic structures using polymeric thin films. The novelty stands in the fabrication of complex monolithic multilayered microstructures from a single polymeric sheet assembled by folding, and bonded by thermo-compression.
Cyclic GMP-dependent Protein Kinase Regulates CCAAT Enhancer-binding Protein β Functions through Inhibition of Glycogen Synthase Kinase-3 (2005)

The CCAAT enhancer-binding protein (C/EBPbeta) plays an important role in the regulation of gene expression during cell proliferation, differentiation, and apoptosis. We previously showed that C/EBPbeta participates in cGMP-regulated transcription of c-fos in osteoblasts (Chen, Y., Zhuang, S., Cassenaer, S., Casteel, D. E., Gudi, T., Boss, G. R., and Pilz, R. B. (2003) Mol. Cell. Biol. 23, 4066-4082). In the present work, we show that cGMP/cGMP-dependent protein kinase (PKG) induced dephosphorylation and activation of C/EBPbeta by inhibiting glycogen synthase kinase-3beta (GSK-3beta). Phosphorylation of GSK-3beta on Ser9 negatively regulates the enzyme activity, and we found that PKG phosphorylated this site both in vitro and in vivo; the in vivo phosphorylation occurred rapidly and preceded C/EBPbeta dephosphorylation. Previous studies with GSK-3 inhibitors suggest that GSK-3beta is a C/EBPbeta kinase in resting cells. We determined that GSK-3beta phosphorylated C/EBPbeta in vitro on Thr189, Ser185, Ser181, and Ser177; C/EBPbeta was phosphorylated on these same sites in intact, unstimulated osteoblasts, and phosphorylation was decreased in cGMP-treated cells. Mutation of the GSK-3 phosphorylation sites in C/EBPbeta prevented C/EBPbeta phosphorylation in resting cells, enhanced C/EBPbeta DNA binding, and led to increased target gene transactivation, mimicking the stimulatory effects of cGMP on C/EBPbeta. cGMP regulation of C/EBPbeta was disrupted by a mutant GSK-3beta(Ala9) resistant to cGMP/PKG phosphorylation and inhibition. We conclude that cGMP increases the DNA binding potential of C/EBPbeta by preventing the negative effects of GSK-3 phosphorylation.
Concepts of deviance and disturbance in children and adolescents: A comparison between the United States and Japan (2000)

Fifth and eleventh graders in the United States ( N = 169) and Japan ( N = 166) were interviewed about their reactions to stories describing various forms of psychological deviance in hypothetical peers. For each story, students were asked if any of the protagonist's behaviours seemed strange or unusual; why these behaviours were strange or unusual; and why the protagonist acted the way he or she did. More Japanese than American students mentioned the psychological reasoning of the individual, and more American than Japanese students mentioned external influences and violation of social norms in explaining and conceptualizing deviant conduct, respectively. Few developmental or gender differences emerged. Results are discussed in terms of the individualism‐collectivism paradigm and cultural differences in attributions for success and failure.
Effects of tumor stroma interaction on global gene expression in breast cancer (2006)

10006 Background: Perturbations in cell-cell interaction are a key feature of cancer. However, the systematic effects of cell-cell interaction on global gene expression in cancer are largely unexplored. We hypothesized that gene expression signatures induced by cell-cell interaction might be of clinical relevance. Methods: We simulated tumor-stroma interaction in vitro by systematically co-cultivating each of 7 different breast cancer cell lines with stromal fibroblasts from 3 different sites, and determined associated gene expression changes with cDNA microarrays. A dataset of pretreatment gene expression profiles from 295 early stage breast cancers (stage 1 and 2) with a median follow up of 12.6 years allowed us to evaluate the prognostic significance of the gene expression signatures of specific cell-cell interactions derived from our ex vivo models. Results: The most prominent response to epithelial-mesenchymal interaction was an induction of interferon-response genes (IRG), observed in 4 of the 7 breast cancer cell lines in co-culture with fibroblasts, but not in normal mammary epithelial cells. In response to close contact with these breast cancer cells, the fibroblasts secreted type I interferons, which, in turn, induced expression of the IRG in the tumor cells. Immunohistochemical analysis of human breast cancer tissues showed that Stat1, the key transcriptional activator of the IRG, and itself an IRG, was expressed in a subset of the cancers, with a striking pattern of elevated expression in the cancer cells in contact with, or close proximity to, the tumor stroma - paralleling the response seen in our ex vivo model. In vivo, expression of the IRGs was remarkably coherent, providing a basis for segregation of the 295 early-stage breast cancers into two groups by unsupervised hierarchical clustering with the IRG. Tumors with high expression levels (n=161) of IRG were associated with significantly shorter overall survival; 59% at 10 years versus 80% at 10 years for tumors with low expression levels (n=134) (log-rank p=0.001). Conclusions: Our results suggest that an interaction between some breast cancer cells and stromal fibroblasts can induce an interferon response, and that this response may be associated with a greater propensity for tumor progression. No significant financial relationships to disclose.
Baseball Players Exhibit Symptoms of Posttraumatic Stress Disorder After Ulnar Collateral Ligament Rupture (124) (2021)

Objectives: The significant psychological impact and prevalence of posttraumatic stress disorder (PTSD) have been thoroughly documented in multiple investigations of patients after anterior cruciate ligament ruptures, but this has not yet been assessed in patients after ulnar collateral ligament (UCL) rupture. Our hypothesis is that symptoms of PTSD are present among baseball players after UCL injury. Methods: Baseball players, from the high school to minor league baseball level who had suffered an acute UCL rupture were recruited at a tertiary care center. Patients completed the Horowitz Impact of Event Scale - Revised (IES-R) to analyze for PTSD symptomatology. Results: A total of 24 patients were enrolled. The mean patient age was 19.2 years (range 15-24 years). Twenty patients (83.3%) were pitchers; 12 pitched exclusively. Six patients surveyed played at the high school level (25%), 15 in college (62.5%), and 3 at the minor league level (12.5%). 100% of patients were male. Over 91% of patients experienced symptoms of intrusion, 87.5% displayed avoidance symptoms, and 79.2% had symptoms of hyperarousal. Twelve patients (50%) scored &gt;24 on the IES-R (PTSD is a clinical concern). 6 patients (25%) reached the threshold for a probable diagnosis of PTSD (³33 on the IES-R). Conclusions: Following UCL rupture, athletes experience substantial emotional trauma, and a significant proportion of patients experience symptoms severe enough to warrant a diagnosis of PTSD.
Control strategies for mutually commutated converter systems without cycloconverter turn-off capability (2008)

Mutually commutated converter systems consisting of a voltage source converter and a cycloconverter connected by a medium-frequency transformer allow bidirectional AC/DC conversion as well as voltage transformation and isolation by the transformer. However, such converter systems require an extra power conversion stage compared to conventional converter systems, which may result in low system efficiency despite the soft-switching commutation scheme. In order to reduce the power losses in the cycloconverter, it is desirable to utilize fast thyristors instead of IGBTs. As a consequence, the cycloconverter valves lack turn-off capability because a thyristor can not be turned off by its gate. This paper describes and evaluates the most common control strategies in order to control a thyristor-based cycloconverter in a mutually commutated converter system. The behaviour of the cycloconverter depends strongly on the chosen control strategy when one of the output currents approaches zero, which may inherently affect the harmonic properties of the output voltages and currents. Experimental results from a 20 kVA prototype show that it is possible to successfully operate a mutually commutated converter system without turn-off capability.
Virtual Drug Repurposing Study Against SARS-CoV-2 TMPRSS2 Target (2020)

&lt;p&gt;Currently, the world suffers from a new coronavirus SARS-CoV-2 that causes COVID-19. Therefore, there is a need for the urgent development of novel drugs and vaccines for COVID-19. Since it can take years to develop new drugs against this disease, here we used a hybrid combined molecular modeling approach in virtual drug screening repurposing study to identify new compounds against this disease. One of the important SARS-CoV-2 targets namely type 2 transmembrane serine protease (TMPRSS2) was screened with NPC’s NIH small molecule library which includes approved drugs by FDA and compounds in clinical investigation. We used 6654 small molecules in molecular docking and top-50 docking scored compounds were initially used in short (10-ns) molecular dynamics (MD) simulations. Based on average MM/GBSA binding free energy results, long (100-ns) MD simulations were employed for the identified hits. Both binding energy results as well as crucial residues in ligand binding were also compared with a positive control TMPRSS2 inhibitor, Camostat mesylate. Based on these numerical calculations we proposed a compound (benzquercin) as strong TMPRSS2 inhibitor. If these results can be validated by in vitro and in vivo studies, benzquercin can be considered to be used as inhibitor of TMPRSS2 at the clinical studies.&lt;/p&gt;
North American Urban Fiction (2014)

Cities are material spaces as much as they are made up of ideas, dreams, and stories. They come into being not only through architectural design but also through the myths and stories that circulate in a specific culture and that constitute a specific nation. If we regard space not as primordial or naturally given but as being produced in social practices (Lefèbvre 1991), cities turn into vibrant and perpetually changing realms where the social imaginary of a culture and its orders of civilization are constantly being negotiated. Urban spaces are particular spaces with their own forms and rules of spatiality but they focalize and intensify the sociocultural processes and values that are virulent elsewhere in a culture (Rosenthal 2011, 11–48). Cities are neither isolated nor self-evident places; they are embedded in the history of space and of spatiality in the respective national culture. Nations define themselves against other nations not only through geographic borders, history, and politics but also through the specific ways they have found to classify and represent spaces.KeywordsUrban SpaceAmerican LiteratureLiterary ImaginationCanadian CitySymbolic SpaceThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Investigation of Post-Plasma Etch Fluorocarbon Residue Characterization, Removal and Plasma-Induced Low-K Damage for Advanced Interconnect Applications (2016)

Modern three-dimensional integrated circuit design is rapidly evolving to more complex architecture. With continuous downscaling of devices, there is a pressing need for metrology tool development for rapid but efficient process and material characterization. In this dissertation work, application of a novel multiple internal reflection infrared spectroscopy metrology is discussed in various semiconductor fabrication process development. Firstly, chemical bonding structure of thin fluorocarbon polymer film deposited on patterned nanostructures was elucidated. Different functional groups were identified by specific derivatization reactions and model bonding configuration was proposed for the first time. In a continued effort, wet removal of these fluorocarbon polymer was investigated in presence of UV light. Mechanistic hypothesis for UV-assisted enhanced polymer cleaning efficiency was put forward supported by detailed theoretical consideration and experimental evidence. In another endeavor, plasma-induced damage to porous low-dielectric constant interlayer dielectric material was studied. Both qualitative and quantitative analyses of dielectric degradation in terms of increased silanol content and carbon depletion provided directions towards less aggressive plasma etch and strip process development. Infrared spectroscopy metrology was also utilized in surface functionalization evaluation of very thin organic films deposited by wet and dry chemistries. Palladium binding by surface amine groups was examined in plasma-polymerized amorphous hydrocarbon films and in self-assembled aminosilane thin films. Comparison of amine concentration under different deposition conditions guided effective process optimization. A time- and cost-effective method such as current FTIR metrology that provides in-depth chemical information about thin films, surfaces, interfaces and bulk layers can be increasingly valuable as critical dimensions continue to scale down and subtle process variances begin to have a significant impact on device performance.
Transforming Solid Wastes Into High Quality Bioenergy Products: Entropy Analysis (2008)

Although energy analysis of a pyrolysis system improves the thermal efficiency of the process, it did not account for the quality of energy used and produced from the process. This paper presents the entropy of analysis of converting solid wastes into useable bio-products during pyrolysis. The entropy balance was performed on a continuous flow pyrolysis reactor system using pine pellets as a feedstock at the pyrolysis temperature of 773 K. An interesting conclusion was drawn from the results that the pyrolysis process converted low quality and high entropy biomass into high quality and low entropy energy products char, bio-oil, and gases. The analysis concluded that the both pyrolysis and combustion were the process of low entropy production and most part of the irreversibility or positive entropy production was mainly associated with condenser unit. The high quality energy producing pyrolysis process may be included as part of the future biorefinery.
Valsartan inhibits angiotensin II-stimulated proliferation of smooth muscle cells from human coronary artery. (1999)

Valsartan may prevent atherosclerosis by inhibiting angiotensin-induced vascular smooth muscle cell proliferation.
Advancements during the past quarter century in on-line monitoring of motor and generator winding insulation (2002)

Electrical insulation plays a critical role in the operation of motor and generator rotor and stator windings. Premature failure of the insulation can cost millions of dollars per day. With advancements in electronics, sensors, computers and software, tremendous progress has been made in the past 25 yr which has transformed on-line insulation monitoring from a rarely used and expensive tool, to the point where 50% of large utility generators in North America are now equipped for such monitoring. This review paper outlines the motivation for online monitoring, discusses the transition to today's technology, and describes the variety of methods now in use for rotor winding and stator winding monitoring.
Role of phosphatidylinositide 3‐kinase in brain‐derived neurotrophic factor‐induced DARPP‐32 expression in medium size spiny neurons in vitro (2001)

Brain-derived neurotrophic factor (BDNF) regulates several properties of striatal dopaminoceptive medium-sized spiny neurons (MSNs) in vivo and in vitro, including expression levels of DARPP-32 (dopamine and cyclic adenosine 3',5'-monophosphate-regulated phosphoprotein, 32 kDa). DARPP-32 is expressed in 96% of the MSNs, and is a key modulator of dopamine actions. We investigated the intracellular signal transduction pathways activated by BDNF in MSNs and via which BDNF induces DARPP-32 expression. We found that phosphorylation of the cyclic AMP response element binding protein (CREB) is only transiently increased following stimulation of MSNs by BDNF, whereas increased phosphorylation of the extracellular signal regulated kinases 1 and 2 (Erk1/2) and Akt is sustained for longer than 4 h. Treatment of cultures with inhibitors of mitogen-activated protein kinase kinase (MEK) or phosphatidylinositide 3-kinase (PI3K) showed that the majority of the BDNF-induced increase in DARPP-32 requires the PI3K pathway. We also found that inhibition of PI3K reduces BDNF-induced Erk phosphorylation, indicating that cross-talk between these pathways may play a prominent role in MSNs.
A piezomotor for the small actuator market (2002)

Because of their intrinsic qualities (high power density, silent working...), piezomotors will eventually replace electromagnetic motors in the small actuators market (mechanical power of few watts). But at present time, the industrialisation cost of this kind of motor is still standing in the way of an important industrial development. This paper describes design and experimental phases of an ultrasonic motor development. The reduction of production cost and the reliability of manufacture process have always been preference shares while preserving workable mechanical characteristics. By so doing, a 20 mm-diameter motor delivering a mechanical output in the 1 watt range could be produced with a cost price lower than 15 $ (excluding power supply and control). Using PZT rods "arranged in 3/4 of wavelength" to generate the travelling wave, this motor makes full use of conical couplers to reduce mechanical losses and optimise mechanical performances.