gebhart/patrepeval huggingface dataset:
Male infertility as a component of Carney complex (2007)

Carney complex (CNC) is a multiple neoplasia syndrome characterised by endocrine tumours, spotty skin pigmentation, cardiac and other myxomas, psamommatous and pigmented schwannomas, large cell calcifying Sertoli cell tumours, and mammary ductal adenomas and other more rare lesions. CNC is inherited in an autosomal-dominant manner and has been mapped to at least two chromosomal loci. Patients who map to the CNC1 locus located on chromosome 17 carry inactivating mutations of the PRKAR1A gene that encodes the cAMP-dependent protein kinase regulatory subunit type 1-alpha (Kirschner et al., 2000). One gene responsible for type 2 (CNC2) is located on chromosome 2p16. Infertility in CNC can be caused by a number of factors; there is evidence that prkar1a deficiency in mice leads directly to infertility (Burton et al., 2006), but patients with CNC also have Sertoli cell tumours and a number of other reasons to affect fertility. We report on an infertile male with CNC and present evidence that male infertility should be considered as part of the phenotype of CNC.
Toward a generalized architecture for unmanned underwater vehicles (2011)

A common feature of unmanned vehicles is their complexity, which grows apace and provides its own challenges. Frameworks for managing this growing complexity have always been one of the key aspects of designing an unmanned vehicle. In this paper, a generalized architecture is proposed to not only address the complexity in developing an unmanned vehicle, but also support the algorithm exchange and technology transfer for integrating efforts from different researchers. We first detail the autonomic element, which is the fundamental unit of the architecture. Then the architecture is constructed, and thorough discussions are given. Finally, simulations on a semi-physical platform are carried out to examine the performance of this architecture.
ChemInform Abstract: Substrate Specificity of N‐Acetylhexosamine Kinase Towards N‐Acetylgalactosamine Derivatives. (2010)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A new method to assess contact lens care compliance. (1993)

Failure to comply with contact lens care instructions is a conspicuous finding among both symptomatic and asymptomatic patients. We used a new methodology to quantify the extent of noncompliance and its clinical significance among 170 soft lens wearers. All patients were interviewed and asked to demonstrate their lens care practices. The significance of deviations from package insert instructions was assessed by 22 ophthalmologists and optometrists with regard to potential impact on safety and comfort. Virtually all patients were noncompliant with at least one required procedure. Noncompliant behavior that could significantly affect safety was more common and judged by practitioners to be of more concern than deviations that could affect comfort. Fifty-seven percent of the patients used disinfection procedures that could seriously affect safety. Overall, the study methodology was found to be very effective both for quantifying noncompliance and for evaluating its clinical significance.
Manipulation of the Ferromagnetism in LaCoO3 Thin Films Through Cation‐Stoichiometric Engineering (2023)

Abstract Spin‐state transitions are an important research topic in complex oxides with the diverse magnetic states involved. In particular, the low‐spin to high‐spin transition in LaCoO 3 thin films has drawn a wide range of attention due to the emergent ferromagnetic state. Although various mechanisms (e.g., structural distortion, oxygen‐vacancy formation, spin‐state ordering) have been proposed, an understanding of what really underlies the emergent ferromagnetism remains elusive. Here, the ferromagnetism in LaCoO 3 thin films is systematically modulated by varying the oxygen pressure during thin‐film growth. Although the samples show dramatic different magnetization, their cobalt valence state and perovskite crystalline structure remain almost unchanged, ruling out the scenarios of both oxygen‐vacancy and spin‐ordering. This work provides compelling evidence that the tetragonal distortion due to the tensile strain significantly modifies the orbital occupancy, leading to a low‐spin to high‐spin transition with emergent ferromagnetism, while samples grown at reduced pressure demonstrate a pronounced lattice expansion due to cation‐off‐stoichiometry, which suppresses the tetragonal distortion and the consequent magnetization. This result not only provides important insight for the understanding of exotic ferromagnetism in LaCoO 3 thin films, but also identifies a promising strategy to design electronic states in complex oxides through cation‐stoichiometry engineering.
Facile, high yield synthesis of functionalized spherosilicates: precursors of novel organolithic macromolecular materials (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFacile, high yield synthesis of functionalized spherosilicates: precursors of novel organolithic macromolecular materialsPradyot A. AgaskarCite this: Inorg. Chem. 1990, 29, 9, 1603Publication Date (Print):May 1, 1990Publication History Published online1 May 2002Published inissue 1 May 1990https://pubs.acs.org/doi/10.1021/ic00334a005https://doi.org/10.1021/ic00334a005research-articleACS PublicationsRequest reuse permissionsArticle Views270Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
High-resolution p-i-n CdTe and CdZnTe X-ray detectors with cooling and rise-time discrimination (1996)

The leakage current of CdTe detectors can be significantly reduced by processing detector crystals with p-i-n structures. Leakage currents of the order of several nA/mm/sup 2/ are achieved at room temperature which compares well with the leakage current of commercially available CdZnTe detectors. The leakage current can be reduced further by cooling the detector to about -30/spl deg/C, where values of about pA/mm/sup 2/ are achieved. These low values enable the use of low-noise, pulsed-optical feedback preamplifiers and higher bias voltages. High bias voltage is necessary for efficient charge collection which reduces spectrum background and peak tailing. Applying rise time discrimination circuitry to the linear amplifier reduces the tailing effect even further, especially at higher radiation energies. We tested several 4 to 30-mm/sup 2/, 0.6 to 1-mm thick p-i-n structure CdTe detector crystals at -20 to -30/spl deg/C with a low-noise pulsed-optical feedback preamplifier and rise-time discriminator, and at best obtained energy resolutions of 700 eV at the 59.5-keV line of /sup 241/Am, 1.2 keV at the 122-keV line of /sup 57/Co, and 2.5 keV at the 662-keV line of /sup 137/Cs. A similar p-i-n structure was processed on a 4-mm/sup 2/ Cd/sub 0.9/Zn/sub 0.1/Te detector crystal in order to reduce its leakage current, and energy resolutions of 368 eV at the 5.9-keV line of /sup 55/Fe, 670 eV at the 59.5-keV line of /sup 241/Am, and 2.6 keV at the 662-keV line of /sup 137/Cs were obtained. However, the detector suffered from a charge collection problem yielding relatively high background under the peaks.
No support for a role for BDNF gene polymorphisms rs11030101 and rs61888800 in major depressive disorder or antidepressant response in patients of Finnish origin (2012)

Brain-derived neurotrophic factor (BDNF) is suggested to play a role in the aetiology of major depression and in the antidepressant response in patients with major depression. Several BDNF gene polymorphisms have been investigated in the above-mentioned context. The aim of the present study was to examine the role of two BDNF gene polymorphisms (rs11030101 and rs61888800) in relation to the response to selective serotonin reuptake inhibitor medication in 106 patients of Finnish origin suffering from major depression. The secondary objective was to evaluate the association of these two BDNF polymorphisms in major depression, as we also had a control population of 386 healthy individuals. We did not find any significant differences in the distribution of these two BDNF gene polymorphisms in our patient population in relation to remission or response to treatment with selective serotonin reuptake inhibitor. Also, there were no significant differences between the patients and the controls.
Performance of trellis coded 16-QAM in a two-link satellite channel (2002)

The performance of trellis coded 16-ary QAM (quadrature amplitude modulation) signaling transmitted through a two-link, nonlinear satellite channel is studied. A 3/4-rate coding and a 4-state, simple convolutional encoder is considered. The bandlimited signal is distorted by a nonlinear amplifier on board the satellite which introduces AM-AM and AM-PM conversions. Additive white Gaussian noise is assumed to be added to the signal on both up and down links. Bit error rates are computed for uncoded 8-ary coherent phase-shift keying (CPSK) and trellis coded 16-ary QAM transmissions as a function of up and down link carrier-to-noise ratios. A raised cosine filter with a roll-off factor of alpha =0.4 equally split between the transmitter and the receiver, giving a spectral efficiency of 2.14 b/s/Hz, is assumed. It is shown that as output backoff is increased, coding gain is also increased and can reach a value of over 3 dB. However, when the best performances of the two signalings are compared, the coding gain is about 1 dB.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Simulated shift work during pregnancy does not impair progeny metabolic outcomes in sheep (2020)

Disrupted maternal circadian rhythms, such as those experienced during shift work, are associated with impaired progeny metabolism in rodents. The effects of disrupted maternal circadian rhythms on progeny metabolism have not been assessed in altricial, non-litter bearing species. We therefore assessed postnatal growth from birth to adulthood, as well as body composition, glucose tolerance, insulin secretion and insulin sensitivity, in pre-pubertal and young adult progeny of sheep exposed to control conditions (CON: 10 males, 10 females) or to a simulated shift work (SSW) protocol for the first one-third (SSW0-7: 11 males, 9 females), the first two-thirds (SSW0-14: 8 males, 11 females) or all (SSW0-21: 8 males, 13 females) of pregnancy. Progeny growth did not differ between maternal treatments. In pre-pubertal progeny (12-14 weeks of age), adiposity, glucose tolerance and insulin secretion during an i.v. glucose tolerance test and insulin sensitivity did not differ between maternal treatments. Similarly, in young adult progeny (12-14 months of age), food intake, adiposity and glucose tolerance did not differ between maternal treatments. At this age, however, insulin secretion in response to a glucose bolus was 30% lower in female progeny in the combined SSW groups compared to control females (P = 0.031), and insulin sensitivity of SSW0-21 singleton females was 236% compared to that of CON singleton female progeny (P = 0.025). At least in this model, maternal SSW does not impair progeny metabolic health, with some evidence of greater insulin action in female young adult progeny.
Chemotactic Responses of Normal Human Basophils to C5a and to Lymphocyte-Derived Chemotactic Factor (1976)

Peripheral blood basophils from normal human subjects responded chemotactically to the complement component C5a and also to the supernatant fluid from cultured human lymphocytes stimulated by mitogens or specific antigen. Basophil chemotactic factor (BCF) was detected in stimulated lymphocyte cultures within 24 hr and increased for the first 3 days. BCF was found after stimulation of lymphocytes by B or T cell mitogens as well as by specific antigen. The amount of BCF in culture fluids was independent of cell proliferation. Monocyte chemotactic factor (MCF) and BCF could not be separated from one another by Sephadex or DEAE chromatography. Both activities were eluted from Sephadex G-100 columns in a m.w. region of about 15,000 daltons and were found after ion exchange chromatography on DEAE in a peak eluted by 0.1 M NaCl. These findings suggest that mitogen or antigen-stimulated lymphocytes secrete a molecule that is chemotactic for both monocytes and basophils. Thus, in the absence of a basophil-specific chemotactic molecule, the preferential accumulation of basophils in certain types of delayed hypersensitivity skin reactions must be due to additional factors such as basophil chemotaxis augmentation factor.
Upgrading the LANSCE accelerator with a SNS RF-driven H− ion source (2020)

The LANSCE accelerator is currently powered by a filament-driven, biased converter-type H<sup>-</sup> ion source that operates at 10%, the highest plasma duty factor for this type of source, using only ∼2.2 SCCM of H<sub>2</sub>. The ion source needs to be replaced every 4 weeks, which takes up to 4 days. The measured negative beam current of 12-16 mA falls below the desired 24 mA acceptance of the LANCSE accelerator. The SNS (Spallation Neutron Source) RF-driven, H<sup>-</sup> ion source injects ∼50 mA of H<sup>-</sup> beam into the SNS accelerator at 60 Hz with a 6% duty factor and an availability of >99.5% but requires ∼30 SCCM of H<sub>2</sub>. Up to 7 A h of H<sup>-</sup> have been produced during the 14-weeks-long source service cycles, which is unprecedented for small emittance, high-current, pulsed H<sup>-</sup> ion sources. The emittance of the SNS source is slightly smaller than the emittance of the LANSCE source. The SNS source also features unrivaled low Cs consumption and can be installed and started up in <12 h. LANSCE and SNS are working toward the use of SNS H<sup>-</sup> ion sources on the LANSCE accelerator because they could (a) fill the LANSCE accelerator to its capacity, (b) decrease the source replacement time by a factor of up to 7, and (c) increase source lifetime by a factor of about 4. This paper discusses some of the challenges that emerge when trying to match a different H<sup>-</sup> source into an existing injector with significantly different characteristics and operating regimes.
Environmental Biotechnology: Principles and Applications (2000)

1 Basics of Microbiology 2 Stoichiometry and Bacterial Energetics 3 Microbial Kinetics 4 Biofilm Kinetics 5 Reactors 6 Complex Systems 7 The Activated Sludge Process 8 Lagoons 9 Aerobic Biofilm Process 10 Nitrification 11 Denitrification 12 Phosphorus Removal 13 Drinking Water Treatment 14 Anaerobic Treatment by Methanogenesis 15 Detoxification of Hazardous Chemicals 16 Bioremediation
Dot Blot Assay for Detection of Antidiacyltrehalose Antibodies in Tuberculous Patients (1999)

A simple dot blot test with diacyltrehalose (DAT) as the antigen was developed to detect anti-DAT antibodies in tuberculous patients. To enhance antigen-antibody reaction detection, rabbit serum raised against human immunoglobulins was used prior to incubation with a protein A-colloidal gold complex. With the dot blot system, it was possible to obtain a sensitivity similar to that of enzyme-linked immunosorbent assay (ELISA) and a specificity of 97.14%, versus a specificity of 94.29% by the ELISA. We conclude that this simple and fast assay could be used in places where ELISA equipment is not easy available and that it might also be applicable with other Mycobacterium tuberculosis immunogenic antigens.
Synthetic vision display with integral sonic boom predictions (2017)

Synthetic vision systems are becoming common in the business jet community. The perspective display of terrain information provides a display of complex information in a visual manner that pilots are accustomed to. Research and flight testing is underway to allow low noise supersonic business jet operations. Widespread acceptance will require regulatory changes, the ability for pilots to predict, and manage where the generated sonic boom will impact people on the ground. A display of the sonic boom impact will be needed for preflight and inflight planning. This paper details the CONOPS, algorithm development, and human machine considerations of a synthetic vision display design incorporating a sonic boom carpet. Using a NASA developed algorithm, sonic boom prediction, Mach cut-off, and sound pressure levels are calculated for current and modified flights plans. The algorithm information is transformed into georeferenced objects, presented on navigation and guidance displays, where pilots can determine whether the current flightplan avoids the generation of sonic booms in noise-sensitive areas. If pilots maneuver away from the flightplan, a dynamically computed predicted boom carpet is presented in which the algorithm is fed an extrapolation of the current flightpath. The resulting depiction is a sonic boom footprint which changes location as the aircraft maneuvers. Using a certain lookahead time for the prediction, the pilot has the ability to shift the location where boom intensity will be at a maximum. Considerations of allowable sound levels for various locations on the ground are incorporated for comparison of the realtime and predicted sonic boom.
Matching chelators to radiometals for radiopharmaceuticals (2013)

Radiometals comprise many useful radioactive isotopes of various metallic elements. When properly harnessed, these have valuable emission properties that can be used for diagnostic imaging techniques, such as single photon emission computed tomography (SPECT, e.g.(67)Ga, (99m)Tc, (111)In, (177)Lu) and positron emission tomography (PET, e.g.(68)Ga, (64)Cu, (44)Sc, (86)Y, (89)Zr), as well as therapeutic applications (e.g.(47)Sc, (114m)In, (177)Lu, (90)Y, (212/213)Bi, (212)Pb, (225)Ac, (186/188)Re). A fundamental critical component of a radiometal-based radiopharmaceutical is the chelator, the ligand system that binds the radiometal ion in a tight stable coordination complex so that it can be properly directed to a desirable molecular target in vivo. This article is a guide for selecting the optimal match between chelator and radiometal for use in these systems. The article briefly introduces a selection of relevant and high impact radiometals, and their potential utility to the fields of radiochemistry, nuclear medicine, and molecular imaging. A description of radiometal-based radiopharmaceuticals is provided, and several key design considerations are discussed. The experimental methods by which chelators are assessed for their suitability with a variety of radiometal ions is explained, and a large selection of the most common and most promising chelators are evaluated and discussed for their potential use with a variety of radiometals. Comprehensive tables have been assembled to provide a convenient and accessible overview of the field of radiometal chelating agents.
Zeroing and testing units developed for Gerdien atmospheric ion detectors (2005)

Low current measurements in atmospheric ion detection using a Gerdien condenser are subjected to numerous sources of error. Zeroing and testing units described in this article, connected as modules to this type of detector, enable some of these errors to be found and eliminated. The zeroing unit provides digital compensation of the zero drift with a digital sample and hold circuit of 12-bit resolution. It overcomes difficulties related to zero drift and techniques used in the zero conductivity determination when the accelerating potential or airflow rate are zero. The testing unit is a current reference of nominally 10−12A intended for testing and correcting the system on current leakage and other measuring deviations due to changes in atmospheric parameters. This unit is an independent battery-powered module, which provides a charge of 10−12C per cycle (frequency of order 1 Hz) to the collecting electrode. The control of Gerdien devices is substantially simplified using the zeroing and testing units realized here. Both units are used during “zero conductivity” regime only.
Supplementary Figure 1 from AKT1 Inhibits Homologous Recombination by Inducing Cytoplasmic Retention of BRCA1 and RAD51 (2023)

Supplementary Figure 1 from AKT1 Inhibits Homologous Recombination by Inducing Cytoplasmic Retention of BRCA1 and RAD51
Modulation of cardiometabolic pathways in skin and serum from patients with psoriasis (2013)

Analyses of targeted genes and their products known to be associated with ASCVD revealed dysregulation of inflammatory (MCP-1 and MDC) and lipid metabolism (LXR-α, PPAR-α) genes in psoriasis. These findings provide evidence of a potential shared pathophysiology linking psoriasis to cardiometabolic diseases.
Brain dysfunction as one cause of CFS symptoms including difficulty with attention and concentration (2013)

We have been able to reduce substantially patient pool heterogeneity by identifying phenotypic markers that allow the researcher to stratify chronic fatigue syndrome (CFS) patients into subgroups. To date, we have shown that stratifying based on the presence or absence of comorbid psychiatric diagnosis leads to a group with evidence of neurological dysfunction across a number of spheres. We have also found that stratifying based on the presence or absence of comorbid fibromyalgia leads to information that would not have been found on analyzing the entire, unstratified patient group. Objective evidence of orthostatic intolerance (OI) may be another important variable for stratification and may define a group with episodic cerebral hypoxia leading to symptoms. We hope that this review will encourage other researchers to collect data on discrete phenotypes in CFS to allow this work to continue more broadly. Finding subgroups of CFS suggests different underlying pathophysiological processes responsible for the symptoms seen. Understanding those processes is the first step toward developing discrete treatments for each.
MR analysis of the substantia innominata in normal aging, Alzheimer disease, and other types of dementia. (2002)

MR analysis reveals age-related shrinkage of the substantia innominata. Atrophy of the substantia innominata, which reflects degeneration in the nucleus basalis of Meynert, is pronounced both in patients with AD and in those with non-AD dementia. MR imaging features in this structure may not be specific to AD.
[Modification of silicone oil removal via limbus of corneal with aphakia]. (2003)

The procedure via one pars plana and limbus or limbus incision after previous lensectomy-vitrectomy is useful in removing the silicone oil tamponade in aphakic eyes because of its simplicity, good curative effect, and fewer complications.