gebhart/patrepeval huggingface dataset:
Adaptation Models of Anisotropic Bone (1997)

A theoretical model and numerical methods were developed for testing different bone internal remodelling stimuli. The keystone of the study was the formulation of a stimulus based on the mechanical invariants of the stress tensor, which took into account bone non-homogeneity and anisotropy. A non-site specific remodelling rate equation was then used for the apparent density whereas anisotropy was fixed and evaluated from anatomic observations. An node-based semi-implicit algorithm with adaptive stepsize was implemented for solving the evolution equation. To preclude numerical artifacts (non-convergence, instability), a phase space description was proposed. As an illustration, the evolution of apparent density distribution surrounding the femoral stem after a Total Hip Replacement was simulated. Three stimuli were tested: the strain energy density stimulus, the octahedral shear stress stimulus, and an anisotropic plastic yield stress stimulus.
VolunteerGet - A novel information system for engaging society in volunteering for emergency care (2008)

This work presents VolunteerGet, a novel information system for engaging society in volunteering for emergency situations. We will use the social networking and location services infrastructure as a means of 1) registering volunteers and other users, 2) spreading the word on volunteering opportunities and increasing the volunteer database, 3) matching the users and volunteers at time and location of need. Such a system has the potential to promote volunteering as a social phenomenon and eventually reduce suffering and mortality.
4-Chloro-2-butanone (2001)

[6322-49-2] C4H7ClO (MW 106.55) InChI = 1S/C4H7ClO/c1-4(6)2-3-5/h2-3H2,1H3 InChIKey = MAGOYBJJLVSJIC-UHFFFAOYSA-N (reagent for Robinson annulation; often interchangeable with methyl vinyl ketone and the corresponding Mannich base 4-dialkylamino-2-butanone) Alternate Names: 2-chloroethyl methyl ketone; 1-chloro-3-butanone. Physical Data: bp 105–110 °C. Solubility: sol most organic solvents. Analysis of Reagent Purity: 1H NMR data are available.1 Form Supplied in: liquid; commercially available. Purification: by distillation. Handling, Storage, and Precautions: use in a fume hood.
Reverse Osmosis Separation of Some Monoamino Monocarboxylic Acids in Aqueous Solutions Using Cellulose Acetate Membrane (1980)

The reverse osmosis separation of some monoamino monocarboxylic acids (1.0x 10-3mol/Z) in single aqueous solutions was carried out by batch cell under an operating pressure of 20Kg/cm2.G at a temperature of 30C. using DDS-cellulose acetate membrane. Taft's polar parameter (Jo*). Taft's steric parameter (-YE,) and nonpolar parameter (.ZS*) governing reverse osmosis separations of nonionized polar aliphatic and alicyclic organic compounds could be applied to amino acids whose substituents are composed of hydrocarbon, such as aliphatic amino acids and part of aromatic amino acids.
A new junction termination technique: The Deep Trench Termination (DT<sup>2</sup>) (2009)

Numerous techniques have been used to improve the voltage handling capability of high voltage power devices with the aim to obtain the breakdown of a plane junction. In this work, a new concept of low cost, low surface and high efficiency junction termination for power devices is presented and experimentally validated. This termination is based on a large and deep trench filled by BCB (BenzoCycloButene) associated to a field plate. Simulation results show the important impact of trench design and field plate width on termination performances. The experimental breakdown voltage of this Deep Trench Termination (DT <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ) is close to 1300 Volts: this value validates not only the concept of the DT <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> but also the choice of the BCB as a good dielectric material for this termination.
First Delisting Approval by the US EPA for a Vitrified Mixed Waste (2002)

Delisting of a vitrified hazardous and radioactive (mixed) waste stored at the Savannah River Site has been approved by Environmental Protection Agency, Region 4. This is the first approval of a delisting petition for a vitrified waste, listed or mixed, in the United States.
Definition of a systematic method for the generation of software test programs allowing the functional verification of system on chip (SoC) (2004)

We present a novel approach for hardware functional verification of system on chip (SoC). Our approach is based on the use of on chip programmable processors like CPUs or DSPs to generate test programs for hardware parts of the design. Traditionally test programs are written at a low level using specific functions for hardware accesses. This method is time consuming and error prone as tests are hand written. We introduce a method allowing the use of high level software test programs. The link between hardware and software is achieved by using a custom operating system. We focus on the benefits that are obtained by handling high level test programs.
ST112 Expressions of methyltransferase enzymes correlate with FOXP3 methylation in the colon mucosa of HIV-1 infected patients (2013)

Human immunodeficiency virus type 1 (HIV-1) modulates host cell epigenetic machinery to control its own replication cycle and induce immune suppression. The immunosuppression is reflected by the activation of the regulatory T-cell subset (Treg). DNA methylation of FOXP3 plays a major role in Treg lineage commitment and immune homeostasis. The aim of the current study is to investigate the mechanisms of aberrant methylation of FOXP3 by HIV-1 infection. Gene expression pattern of DNA methylation enzymes in the colon mucosa from HIV-infected patients and control subjects was investigated by Microarray analysis. FOXP3 promoter methylation in the same subjects was measured using Pyrosequencing. Our data indicated that FOXP3 promoter was significantly (p=< 0.0001) demethylated in HIV-infected patients compared to control subjects (% methylation 1.2 ± 0.4 and 36.7 ±1.6, respectively). Expression of DNA methyltransferase 1-associated protein 1(DMAP1), methyltransferase like 7B (METTL7B), and methyltransferase like 10 (METTL10), were significantly (p=0.028, 0.002, and 0.016 respectively) down regulated in HIV-infected patients compared to controls and had a significant positive correlation to FOXP3 promoter methylation (r= 0.89, p=0.001; r= 0.75, p= 0.017; r= 0.87, p=0.002 respectively). DMAP1is known to be a co-repressor that stimulates DNA methylation globally and locally, while the function of METTL7B and METTL10 is not yet well characterized. This study suggests possible mechanisms by which HIV may alter methylation pattern of FOXP3 in T reg and immune homeostasis.
Adaptive Secondary Transform For Improved Image Coding Efficiency In JPEG2000 (2020)

This paper proposes a secondary transform for wavelet based image compression, whose aim is to predict detail sub-bands from the corresponding low-pass sub-band so as to improve energy compaction. The proposed prediction strategy exploits the orientation of local image features to untangle aliasing components in the low-pass sub-band, and achieves prediction by projecting the cleaned synthesized low-pass sub-band back into the wavelet domain. At low bit rates, the proposed scheme can considerably reduce distortion in a JPEG 2000 based compression framework, especially for images with strong geometric flow.
Welcome message (2009)

The organizing committee welcomes all participants to the 2009 IEEE International Workshop on Robotic and Sensors Environments, held in Lecco (Lake Como), Italy, on November 6–7, 2009. The two-day program provides an opportunity for researchers interested in various applications of sensing and robotics to discuss their latest results and exchange ideas on the new trends. The main objective of the workshop is to encourage discussion on a broad range of topics and to stimulate new collaborations among the participants.
SNPWaveTM: a flexible multiplexed SNP genotyping technology (2004)

Scalable multiplexed amplification technologies are needed for cost-effective large-scale genotyping of genetic markers such as single nucleotide polymorphisms (SNPs). We present SNPWave, a novel SNP genotyping technology to detect various subsets of sequences in a flexible fashion in a fixed detection format. SNPWave is based on highly multiplexed ligation, followed by amplification of up to 20 ligated probes in a single PCR. Depending on the multiplexing level of the ligation reaction, the latter employs selective amplification using the amplified fragment length polymorphism (AFLP) technology. Detection of SNPWave reaction products is based on size separation on a sequencing instrument with multiple fluorescence labels and short run times. The SNPWave technique is illustrated by a 100-plex genotyping assay for Arabidopsis, a 40-plex assay for tomato and a 10-plex assay for Caenorhabditis elegans, detected on the MegaBACE 1000 capillary sequencer.
Scalable Capacity Estimation for Nonlinear Elastic All-Optical Core Networks (2019)

Routing and wavelength assignment (RWA) algorithms must strike a balance between finding routes with high quality of transmission (QoT) and finding routes that will not interfere with allocating future traffic. Too much emphasis on the first will concentrate traffic along major routes causing congestion whilst too much emphasis on the second will cause individual transceivers to operate below their capabilities increasing both cost and power consumption. This paper presents a low-complexity algorithm that shows that focusing on wavelength packing allows for greater overall traffic whilst giving only slight penalties for latency and required transceivers. Our algorithm comfortably outperforms kSP-FF routing for the same complexity and typically betters congestion aware routing whilst reducing complexity. We show these results on 4 simplified networks based on deployed topologies before replicating them on 2,000 artificially generated topologies based on real node locations in Germany and the USA. Capacity for each topology was found with an integer linear program to which our algorithm compares favorably suggesting it provides a scalable alternative to global optimization.
IER-407 CED-3b Rev-1: Experiment Execution Report for the Inherently Safe Subcritical Assembly (ISSA) Subcritical Measurements (2018)

This set of benchmark subcritical multiplicity experiments was conducted at the ISSA experiment center of Lawrence Livermore National Laboratory. The purpose of these subcritical experiments, as described in the ISSA final design report, was to measure fission neutrons by collecting time-tagged data corresponding to a maximum multiplication of approximately 20. The fission source for this experiment was Materials Test Reactor (MTR)-type highly enriched uranium fuel assembly, which is composed of nineteen fuel plates. One, two, four, six and nine ISSA fuel assemblies were closely packed and loaded inside a support fixture assembly and immersed in water. Four 3He proportional counters were placed around the fuel assemblies, and list-mode experimental data was taken. Additionally, efficiency calibration measurements with calibrated neutron sources were conducted. The LLNL developed codes BIGFIT and OSANTI RESTART will be used to evaluate the measured data and calculate the experimental multiplication.
[How I explore ... the risk of metastasis from melanoma]. (2001)

The development of new therapeutic protocols for malignant melanoma calls for an upgraded assessment of the individual risk to develop metastases. The predictive sentinel lymph node method is best practiced in a multidisciplinary approach. The selective lymphadenectomy of the first draining lymph node is followed by minutely detailed histologic examination combined with immunohistochemistry.
New Standardized Extensions of MPEG4-AVC/H.264 for Professional-Quality Video Applications (2007)

To support high quality video applications, the Joint Video Team (JVT) has recently added five new profiles, two new supplemental enhancement information (SEI) messages, and two new extended gamut color space indicators to the MPEG4-AVC/H.264 video coding standard. The new profiles include substantial feature enhancements for high-quality video applications, including improved-efficiency 4:4:4 video format coding, improved-efficiency lossless macroblock coding, coding 4:4:4 video pictures using three separately-coded color planes, and support of bit depths up to 14 bits per sample. The new features were developed to support a wide range of applications where high quality video compression is demanded, including professional and semi-professional scenarios in particular. They also anticipate the introduction of higher fidelity displays. In this paper, the new extensions are presented along with quantitaive estimates of the benefits of the new features and a discussion of the target application environments.
Light Localization Effect on the Optical Properties of Opals Doped with Gold Nanoparticles (2008)

Polystyrene artificial opals having both different microsphere diameters and gold nanoparticles (AuNP) doping levels have been prepared and their spectroscopic characterization has been performed. Reflectance spectra of doped opals show a red shift of the photonic band gap and a reduction of its width and intensity upon increasing AuNP doping level, but they do not show any direct evidence of AuNP plasmon resonance. Transmittance spectra of the same samples recorded on the same spot area show, instead, a doping level dependent line shape. For the highest doping level a complicated sigmoidal line shape due to the overlap of broad AuNP absorption and photonic crystal stop band is observed. This unusual effect is accounted for by considering the localization of standing electromagnetic waves within both the microspheres and the interstices where the AuNP are embedded.
Resection of the vaginal vault for vaginal recurrence of cervical cancer after hysterectomy and brachytherapy (2015)

Vaginal vault resection is an effective treatment for vaginal recurrence of cervical cancer after hysterectomy and radiotherapy. However, complications of this procedure can be expected to reduce quality of life. Therefore, this operation should be selected with great care.
NIST Reference Densitometer for Visual Diffuse Transmission Density (1999)

The Optical Technology Division of the National Institute of Standards and Technology has developed a new reference densitometer for measuring visual diffuse transmission densities using the diffuse influx mode. This densitometer is used to calibrate both x-ray and photographic film step tablet Standard Reference Materials. The design, characterization, and operation of the densitometer are detailed. The densitometer was fully characterized both to verify compliance with the applicable documentary standards and to determine the combined uncertainty in transmission density associated with the calibrations.
Influence of Instrument Settings on Flow Signal and Background Noise in Power Doppler US (1999)

Three Doppler instrument settings--wall filter level, pulse repetition frequency, and Doppler gain--have reciprocal influences on SND.
Palladium-catalyzed asymmetric synthesis of 2-pyrrolidinones with a quaternary carbon stereocenter (2012)

A palladium-catalyzed asymmetric synthesis of 2-pyrrolidinones with a quaternary stereocenter at the 3-position has been achieved by the reaction of γ-methylidene-δ-valerolactones with alkyl isocyanates. High enantioselectivity has been realized by employing a newly synthesized chiral phosphoramidite ligand.
Effects of a contoured articular prosthetic device on tibiofemoral peak contact pressure: a biomechanical study (2007)

Many middle-aged patients are affected by localized cartilage defects that are neither appropriate for primary, nor repeat biological repair methods, nor for conventional arthroplasty. This in vitro study aims to determine the peak contact pressure in the tibiofemoral joint with a partial femoral resurfacing device (HemiCAP, Arthrosurface Inc., Franklin, MA, USA). Peak contact pressure was determined in eight fresh-frozen cadaveric specimens using a Tekscan sensor placed in the medial compartment above the menisci. A closed loop robotic knee simulator was used to test each knee in static stance positions (5 degrees /15 degrees /30 degrees /45 degrees ) with body weight ground reaction force (GRF), 30 degrees flexion with twice the body weight (2tBW) GRF and dynamic knee-bending cycles with body weight GRF. The ground reaction force was adjusted to the living body weight of the cadaver donor and maintained throughout all cycles. Each specimen was tested under four different conditions: Untreated, flush HemiCAP implantation, 1-mm proud implantation and 20-mm defect. A paired sampled t test to compare means (significance, P < or = 0.05) was used for statistical analysis. On average, no statistically significant differences were found in any testing condition comparing the normal knee with flush device implantation. With the 1-mm proud implant, statistically significant increase of peak contact pressures of 217% (5 degrees stance), 99% (dynamic knee bending) and 90% (30 degrees stance with 2tBW) compared to the untreated condition was seen. No significant increase of peak contact pressure was evaluated with the 20-mm defect. The data suggests that resurfacing with the HemiCAP does not lead to increased peak contact pressure with flush implantation. However, elevated implantation results in increased peak contact pressure and might be biomechanically disadvantageous in an in vivo application.
Epithelial Tight Junctional Changes in Colorectal Cancer Tissues (2011)

Colorectal cancer (CRC) is one of the most common cancers in the western world. Early screening and detection could be highly preventative and therefore reduce mortality. Tight junctions (TJ) are well known for their function in controlling paracellular traffic of ions and molecules. It has become increasingly evident that TJs play a crucial role in maintaining cell-cell integrity, and the loss of cell junctional sealing could involve itself in the processes of carcinoma and cancer metastasis. If correlations between altered TJ proteins and CRC presence or invasiveness could be established, they may serve as important markers and guidelines for prophylactic and prognostic purposes, along with other screening methods. This review will present recent data from clinical and animal studies showing how altered TJ protein expression is a feature of certain CRCs. The up-regulation of claudin-1 in many CRCs is especially noteworthy. The focus of this article is simply on the association - however imperfect - between CRC and the major TJ transmembrane barrier proteins, namely claudins and occludin. Any causal relationship between TJ protein change and neoplasia remains conclusively unproven at present.
The Absolute Configuration of the C1 Atom in Retronecanone (1-Methyl-7-oxopyrrolizidine) (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Absolute Configuration of the C1 Atom in Retronecanone (1-Methyl-7-oxopyrrolizidine)Roger Adams and D. FlešCite this: J. Am. Chem. Soc. 1959, 81, 18, 4946–4951Publication Date (Print):September 1, 1959Publication History Published online1 May 2002Published inissue 1 September 1959https://pubs.acs.org/doi/10.1021/ja01527a047https://doi.org/10.1021/ja01527a047research-articleACS PublicationsRequest reuse permissionsArticle Views123Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Human amnion‐derived mesenchymal stem cells are a potential source for uterine stem cell therapy (2008)

Collectively, these results suggest that HAM cells are a potential source of mesenchymal stem cells with therapeutic potential.
Dissecting the Proline Effect:  Dissociations of Proline Radicals Formed by Electron Transfer to Protonated Pro-Gly and Gly-Pro Dipeptides in the Gas Phase (2007)

We report a combined experimental and computational study of the proline effect in model dipeptides Pro-Gly and Gly-Pro. Gas-phase protonated peptide ions were discharged by glancing collisions with potassium or cesium atoms at 3 keV collision energies, and the peptide radical intermediates and their dissociation products were analyzed following collisional ionization to anions. The charge reversal (+CR-) mass spectra of (Pro-Gly + H)+(1a+) and (Gly-Pro + H)+ (2a+) showed dramatic differences and thus provided a sensitive probe of ion structure. Whereas 1a+ completely dissociated upon charge inversion, 2a+ gave a nondissociated anion as the most abundant product. Ab initio and density functional theory calculations provided structures and vertical recombination energies (REvert) for 1a+ and 2a+. The recombination energies, REvert = 3.07 and 3.36 eV for 1a+ and 2a+, respectively, were lower than the alkali metal ionization energies and indicated that the collisional electron transfer to the peptide ions was endoergic. Radical 1a* was found to exist in a very shallow local energy minimum, with transition state energies for loss and migration of H indicating very facile dissociation. In contrast, radical 2a* was calculated to spontaneously isomerize upon electron capture to a stable dihydroxycarbinyl isomer (2e*) that can undergo consecutive and competitive isomerizations by proline ring opening and intramolecular hydrogen atom transfers to yield stable radical isomers. Radical 2e* and its stable isomers were calculated to have substantial electron affinities and thus can form the stable anions that were observed in the +CR- mass spectra. The calculated TS energies and RRKM kinetic analysis indicated that peptide N-C alpha bond dissociations compete with pyrrolidine ring openings triggered by radical sites at both the N-terminal and C-terminal sides of the proline residue. Open-ring intermediates were found in which loss of an H atom was energetically preferred over backbone dissociations. This provided an explanation for the proline effect causing low incidence of electron capture dissociations of N-C alpha bonds adjacent to proline residues in tryptic peptides and also for some peculiar behavior of proline-containing protein cation-radicals.