gebhart/patrepeval huggingface dataset:
The Study of Antioxidant and Anticarcinogenic Green Tea and Black Tea (2007)

Tea is one of the most popular beverages consumed worldwide. The relationship between tea consumption and human cancer incidence is an important concern. The effect of tea extract and ingredients, polyphenol and caffeine on the mutagenicity of Sodium Azide was examined in vitro by using Salmonella typhimurium TA100, TA98 and TA1535 in the presence of induced rat liver S9 fractions. Experimental studies have demonstrated the significant antimutagenic and anticarcinogenic effects of both Green and Black tea and its polyphenol and caffeine multiple mutational assay. Caffeine was the less active. Tea comes in many variants. Common tea such as Black tea contains little antioxidant and the amount of caffeine. Green tea has about the caffeine, but contains a good amount of antioxidant.
Crystalline polymeric carbon dioxide stable at megabar pressures (2018)

Carbon dioxide is a widespread simple molecule in the Universe. In spite of its simplicity it has a very complex phase diagram, forming both amorphous and crystalline extended phases above 40 GPa. The stability range and nature of these phases are still debated, especially in view of their possible role within the deep carbon cycle. Here, we report static synchrotron X-ray diffraction and Raman high-pressure experiments in the megabar range providing evidence for the stability of the polymeric phase V at pressure-temperature conditions relevant to the Earth's lowermost mantle. The equation of state has been extended to 120 GPa and, contrary to earlier experimental findings, neither dissociation into diamond and ε-oxygen nor ionization was observed. Severe deviatoric stress and lattice deformation along with preferred orientation are removed on progressive annealing, thus suggesting CO<sub>2</sub>-V as the stable structure also above one megabar.
Cancer Survivors and Returning to Work Perspectives from Occupational Health Physicians in Korea (2019)

As a preliminary study, we found that OHPs were found to have little experience in treating cancer survivors and undergo difficulties owing to poor collaboration with workplaces and communication with patients. This study will provide basic data for future studies to promote cancer survivors' return to workplaces.
Objective and Subjective Assessments of Sleep in Children: Comparison of Actigraphy, Sleep Diary Completed by Children and Parents’ Estimation (2020)

In research and clinical contexts, parents' report and sleep diary filled in by parents are often used to characterize sleep-wake rhythms in children. The current study aimed to investigate children self-perception of their sleep, by comparing sleep diaries filled in by themselves, actigraphic sleep recordings, and parental subjective estimation. Eighty children aged 8-9 years wore actigraph wristwatches and completed sleep diaries for 7 days, while their parents completed a sleep-schedule questionnaire about their child' sleep. The level of agreement and correlation between sleep parameters derived from these three methods were measured. Sleep parameters were considered for the whole week and school days and weekends separately and a comparison between children with high and low sleep efficiency was carried out. Compared to actigraphy, children overestimated their sleep duration by 92 min and demonstrated significant difficulty to assess the amount of time they spent awake during the night. The estimations were better in children with high sleep efficiency compared to those with low sleep efficiency. Parents estimated that their children went to bed 36 min earlier and obtained 36.5 min more sleep than objective estimations with actigraphy. Children and parents' accuracy to estimate sleep parameters was different during school days and weekends, supporting the importance of analyzing separately school days and weekends when measuring sleep in children. Actigraphy and sleep diaries showed good agreement for bedtime and wake-up time, but not for SOL and WASO. A satisfactory agreement for TST was observed during school days only, but not during weekends. Even if parents provided more accurate sleep estimation than children, parents' report, and actigraphic data were weakly correlated and levels of agreement were insufficient. These results suggested that sleep diary completed by children provides interesting measures of self-perception, while actigraphy may provide additional information about nocturnal wake times. Sleep diary associated with actigraphy could be an interesting tool to evaluate parameters that could contribute to adjust subjective perception to objective sleep values.
MR Imaging of Liver Fibrosis: Current State of the Art (2009)

Chronic liver disease is a major public health problem worldwide. Liver fibrosis, a common feature of almost all causes of chronic liver disease, involves the accumulation of collagen, proteoglycans, and other macromolecules within the extracellular matrix. Fibrosis tends to progress, leading to hepatic dysfunction, portal hypertension, and ultimately cirrhosis. Liver biopsy, the standard of reference for diagnosing liver fibrosis, is invasive, costly, and subject to complications and sampling variability. These limitations make it unsuitable for diagnosis and longitudinal monitoring in the general population. Thus, development of a noninvasive, accurate, and reproducible test for diagnosis and monitoring of liver fibrosis would be of great value. Conventional cross-sectional imaging techniques have limited capability to demonstrate liver fibrosis. In clinical practice, imaging studies are usually reserved for evaluation of the presence of portal hypertension or hepatocellular carcinoma in cases that have progressed to cirrhosis. In response to the rising prevalence of chronic liver diseases in Western nations, a number of imaging-based methods including ultrasonography-based transient elastography, computed tomography-based texture analysis, and diverse magnetic resonance (MR) imaging-based techniques have been proposed for noninvasive diagnosis and grading of hepatic fibrosis across its entire spectrum of severity. State-of-the-art MR imaging-based techniques in current practice and in development for noninvasive assessment of liver fibrosis include conventional contrast material-enhanced MR imaging, double contrast-enhanced MR imaging, MR elastography, diffusion-weighted imaging, and MR perfusion imaging.
A Correlation-Based Anomaly Detection Model for Wireless Body Area Networks Using Convolutional Long Short-Term Memory Neural Network (2022)

As the Internet of Healthcare Things (IoHT) concept emerges today, Wireless Body Area Networks (WBAN) constitute one of the most prominent technologies for improving healthcare services. WBANs are made up of tiny devices that can effectively enhance patient quality of life by collecting and monitoring physiological data and sending it to healthcare givers to assess the criticality of a patient and act accordingly. The collected data must be reliable and correct, and represent the real context to facilitate right and prompt decisions by healthcare personnel. Anomaly detection becomes a field of interest to ensure the reliability of collected data by detecting malicious data patterns that result due to various reasons such as sensor faults, error readings and possible malicious activities. Various anomaly detection solutions have been proposed for WBAN. However, existing detection approaches, which are mostly based on statistical and machine learning techniques, become ineffective in dealing with big data streams and novel context anomalous patterns in WBAN. Therefore, this paper proposed a model that employs the correlations that exist in the different physiological data attributes with the ability of the hybrid Convolutional Long Short-Term Memory (ConvLSTM) techniques to detect both simple point anomalies as well as contextual anomalies in the big data stream of WBAN. Experimental evaluations revealed that an average of 98% of F1-measure and 99% accuracy were reported by the proposed model on different subjects of the datasets compared to 64% achieved by both CNN and LSTM separately.
Bioresorbable Plates and Screws for Clinical Applications: A Review (2012)

Bioresorbable implants are being widely used for fracture fixation in orthopaedic surgery and the market is expanding rapidly worldwide. Bioresorbable materials slowly dissolve in the human body, such that a second operation to remove the synthetic material is not needed. Bioresorbable implants have expanded the armamentarium of the surgeon, especially in the field of sports medicine. Interference screws, plates, pins, suture anchors, meniscal repair implants, and simple fracture fixation implants are the most commonly used resorbable implants for anterior cruciate ligament reconstruction, shoulder surgery, meniscal repair, and fracture care. However, many clinicians continue to rely on metal fixation, mainly due to the high mechanical strength and to the complications reported with some of the available resorbable implant materials. The goal of the present paper is to present an overview on the available resorbable materials and their applications with a particular focus on new developments and trends in the field.
P2‐197: Mortality After a Diagnosis of Early‐Onset Alzheimer's Disease Versus Late‐Onset Alzheimer's Disease: A Propensity Score Matching Analysis (2016)

We aimed to examine the mortality risk in patients with EOAD compared to those with LOAD in a large sample. We also applied propensity score matching (PSM) to minimize confounding biases in comparison between EOAD and LOAD. We obtained data from elderly Korean subjects with Alzheimer’s disease (n = 5,097) aged 60 years or older at baseline from the CREDOS study from November 2005 to July 2013. We conducted a propensity score matching to reduce the bias due to confounding variables related to survival in patients with Alzheimer’s disease. Through propensity score matching 312 subjects with EOAD and 624 subjects with LOAD were selected. The risk of mortality of EOAD and LOAD was evaluated by Cox proportional hazard analyses controlling age at diagnosis, general cognitive function (MMSE), barthel index (ADL), body mass index (BMI), degree of white matter hyperintensity (WMH), delusion and apathy. The mean (with SD) follow-up duration of the participants was 1.7 (0.9) years. Cox model showed that patients with EOAD have higher risk of mortality compared to those with LOAD (Hazard Ratio: 2.012, 95% CI: 1.011∼4.003, p-value: 0.046). This results supports the assumption EOAD has a more malignant course than LOAD. It were unchanged after adjusting for age at diagnosis, general cognitive function, nutritional factor related to BMI and physical disability using ADL. In particular, the impact of EOAD on increased risk of mortality maintained regardless of direct ageing effect on mortality. Our results provide further support for distinct clinical course in EOAD compared to LOAD, especially the risk of mortality.
Dopamine Transporter Endocytic Trafficking in Striatal Dopaminergic Neurons: Differential Dependence on Dynamin and the Actin Cytoskeleton (2013)

Dopaminergic signaling profoundly impacts rewarding behaviors, movement, and executive function. The presynaptic dopamine (DA) transporter (DAT) recaptures released DA, thereby limiting synaptic DA availability and maintaining dopaminergic tone. DAT constitutively internalizes and PKC activation rapidly accelerates DAT endocytosis, resulting in DAT surface loss. Longstanding evidence supports PKC-stimulated DAT trafficking in heterologous expression studies. However, PKC-stimulated DAT internalization is not readily observed in cultured dopaminergic neurons. Moreover, conflicting reports implicate both classic and nonclassic endocytic mechanisms mediating DAT trafficking. Prior DAT trafficking studies relied primarily upon chronic gene disruption and dominant-negative protein expression, or were performed in cell lines and cultured neurons, yielding results difficult to translate to adult dopaminergic neurons. Here, we use newly described dynamin inhibitors to test whether constitutive and PKC-stimulated DAT internalization are dynamin-dependent in adult dopaminergic neurons. Ex vivo biotinylation studies in mouse striatal slices demonstrate that acute PKC activation drives native DAT surface loss, and that surface DAT surprisingly partitions between endocytic-willing and endocytic-resistant populations. Acute dynamin inhibition reveals that constitutive DAT internalization is dynamin-independent, whereas PKC-stimulated DAT internalization is dynamin-dependent. Moreover, total internal reflection fluorescence microscopy experiments demonstrate that constitutive DAT internalization occurs equivalently from lipid raft and nonraft microdomains, whereas PKC-stimulated DAT internalization arises exclusively from lipid rafts. Finally, DAT endocytic recycling relies on a dynamin-dependent mechanism that acts in concert with the actin cytoskeleton. These studies are the first comprehensive investigation of native DAT trafficking in ex vivo adult neurons, and reveal that DAT surface dynamics are governed by complex multimodal mechanisms.
Sensitivity of the (He3,t) Reaction to Final-State Configurations (1970)

The reactions $^{27}\mathrm{Al}(^{3}\mathrm{He},t)^{27}\mathrm{Si}$ and $^{23}\mathrm{Na}(^{3}\mathrm{He},t)^{23}\mathrm{Mg}$ have been studied at a bombarding energy of 18 MeV. Within each nucleus angular distributions leading to states of the same spin and parity have been found to show a pronounced dependence on the configuration of the final state, contrary to previous suggestions. Such a dependence is consistent with the results of microscopic distorted-wave Born-approximation calculations.
Cytoplasmic sequestration of an O 6 -methylguanine-DNA methyltransferase enhancer binding protein in DNA repair-deficient human cells (1997)

O6-Methylguanine-DNA methyltransferase (MGMT), an enzyme that repairs adducts at O6 of guanine in DNA, is a major determinant of susceptibility to simple methylating carcinogens or of tumor response to anticancer chloroethylating drugs. To investigate the mechanisms underlying cellular expression of this DNA repair enzyme, we focused on the role of a 59-bp enhancer of the human MGMT gene in the regulation of its expression. By using chloramphenicol acetyltransferase reporter assays, we found that the enhancer activity, which was present in both MGMT-expressing (Mer+) and -deficient (Mer-) cells, correlated with the endogenous MGMT activity in Mer+ cell lines. Band-shift assays and deletion analysis of the 59-bp sequence defined a minimal 9-mer cis element (5'-CTGGGTCGC-3') for specific trans factor binding. The MGMT enhancer binding protein (MEBP), 45 kDa by Southwestern blot analysis, was present in the nuclei of all Mer+ cells tested but was apparently restricted to the cytoplasm of Mer- cells. We conclude that the MEBP-enhancer interaction plays an important role in regulating constitutive MGMT expression in Mer+ cells and that MEBP exclusion from the nucleus may account for the down-regulation of MGMT in Mer- cells.
Treatment of 813 Zygoma-Lateral Orbital Complex Fractures: New Aspects (1991)

A 10-year experience with surgical treatment of 813 zygomalateral orbital complex fractures is reviewed. Regardless of the type or severity of the fracture pattern, concomitant fractures of the orbital floor and rim were approached exclusively through the transconjunctival approach without a lateral canthotomy. The advantages of this approach compared with the subciliary access are the avoidance of a visible scar and markedly reduced incidence of postoperative lower eyelid complications such as ectropion and edema. Implants of lyophilized dura or cartilage and autogenous bone were used to reconstruct orbital floor defects. Malar asymmetry is a frequent complication of zygoma fractures resulting from inadequate three-dimensional reduction. Methods for accurate reduction and stabilization, indications for closed and open reduction, and management of the fractured infraorbital rim are emphasized. The indications for miniplates vs wire ligatures for the infraorbital rim are discussed. Long-term follow up and evaluation of the results with regard to the fracture pattern, complications, maxillary sinus dysfunction, and facial and orbital symmetry are presented.
Biosynthesis and incorporation of side‐chain‐truncated lignin monomers to reduce lignin polymerization and enhance saccharification (2012)

Lignocellulosic biomass is utilized as a renewable feedstock in various agro-industrial activities. Lignin is an aromatic, hydrophobic and mildly branched polymer integrally associated with polysaccharides within the biomass, which negatively affects their extraction and hydrolysis during industrial processing. Engineering the monomer composition of lignins offers an attractive option towards new lignins with reduced recalcitrance. The presented work describes a new strategy developed in Arabidopsis for the overproduction of rare lignin monomers to reduce lignin polymerization degree (DP). Biosynthesis of these 'DP reducers' is achieved by expressing a bacterial hydroxycinnamoyl-CoA hydratase-lyase (HCHL) in lignifying tissues of Arabidopsis inflorescence stems. HCHL cleaves the propanoid side-chain of hydroxycinnamoyl-CoA lignin precursors to produce the corresponding hydroxybenzaldehydes so that plant stems expressing HCHL accumulate in their cell wall higher amounts of hydroxybenzaldehyde and hydroxybenzoate derivatives. Engineered plants with intermediate HCHL activity levels show no reduction in total lignin, sugar content or biomass yield compared with wild-type plants. However, cell wall characterization of extract-free stems by thioacidolysis and by 2D-NMR revealed an increased amount of unusual C₆C₁ lignin monomers most likely linked with lignin as end-groups. Moreover the analysis of lignin isolated from these plants using size-exclusion chromatography revealed a reduced molecular weight. Furthermore, these engineered lines show saccharification improvement of pretreated stem cell walls. Therefore, we conclude that enhancing the biosynthesis and incorporation of C₆C₁ monomers ('DP reducers') into lignin polymers represents a promising strategy to reduce lignin DP and to decrease cell wall recalcitrance to enzymatic hydrolysis.
The critical role of lymph nodes in corneal alloimmunization and graft rejection. (2001)

Draining CLNs play a critical role in allosensitization and rejection. In contrast to the spleen, draining CLNs do not appear to play a critical role in tolerance induction in corneal transplantation.
Characterization of energetic and structural heterogeneities of activated carbons (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCharacterization of energetic and structural heterogeneities of activated carbonsM. Jaroniec, R. Madey, X. Lu, and J. ChomaCite this: Langmuir 1988, 4, 4, 911–917Publication Date (Print):July 1, 1988Publication History Published online1 May 2002Published inissue 1 July 1988https://pubs.acs.org/doi/10.1021/la00082a023https://doi.org/10.1021/la00082a023research-articleACS PublicationsRequest reuse permissionsArticle Views64Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Reduced Degrees of Freedom Gaussian Mixture Model Fitting for Large Scale History Matching Problems (2019)

Abstract Gaussian-mixture-model (GMM) fitting has been proved a robust method to generate high quality, independent conditional samples of the posterior probability density function (PDF) by conditioning reservoir models to production data. However, the number of degrees-of-freedom (DOF) for all unknown GMM parameters may become huge for large-scale history-matching problems. A new formulation of GMM fitting with reduced number of DOF is proposed in this paper, to save memory-usage and reduce computational cost. Its performance is compared with other methods of GMM. The GMM fitting method can significantly improve the accuracy of the GMM approximation by adding more Gaussian components. In the full-rank GMM fitting formulation, both memory-usage and computational cost are proportional to the number of Gaussian components. In the reduced DOF GMM fitting formulation, the covariance matrix of the newly added Gaussian component is efficiently parameterized, using products of a low number of vectors and their transposes, whereas the other Gaussian components are simply modified by multipliers. Thus, memory usage and computational cost increase only modestly as the number of Gaussian components increases. Unknown GMM parameters, including the parameterized covariance matrix and mixture weighting factor for each Gaussian component, are first determined by minimizing the error that measures the distance between the GMM approximation and the actual posterior PDF. Then, performance of the new method is benchmarked against other methods using test problems with different numbers of uncertain parameters. The new method is found to perform more efficiently than the full-rank GMM fitting formulation, e.g., it further reduces the memory usage and computational cost by a factor of 5 to 10, while it achieves comparable accuracy. Although it is less efficient than the L-GMM approximation based on local linearization, it achieves much higher accuracy, e.g., it manages to further reduce the error by a factor of 20 to 600. Finally, the new method together with the parallelized acceptance-rejection (AR) algorithm is applied to a history matching problem. It is found to reduce the computational cost (i.e., the number of simulations required to generate an accepted conditional realization on average) by a factor of 200 when compared with the Markov chain Monte Carlo (MCMC) method, while the quality of accepted GMM samples is comparable to the MCMC samples. Uncertainty of reservoir model parameters and production forecasts can be properly quantified with accepted GMM samples by conditioning to production data.
Automatic Question and Answer Generation from Course Materials (2017)

This paper presents a Question and Answer Generating System based on the approach of Natural Language Processing. As an examiner needs to ask suitable and good questions and prepare correct answers. The potential benefits this system may assist examiners meeting appropriate questions and answers. When a text input is given, this system deeply analyzes the text content and generates a set of questions and suitable answers.