gebhart/patrepeval huggingface dataset:
Feline chronic renal failure: calcium homeostasis in 80 cases diagnosed between 1992 and 1995 (1998)

Eighty cats with chronic renal failure (CRF) were evaluated in a prospective study to investigate the prevalence and aetiopathogenesis of renal secondary hyperparathyroidism (RHPTH), using routine plasma biochemistry and assays of parathyroid hormone (PTH), blood ionised calcium and 1,25 dihydroxycholecalciferol (1,25[OH]2D3). Hyperparathyroidism was a frequent sequela of CRF, affecting 84 per cent of cats with CRF, the severity and prevalence of RHPTH increasing with the degree of renal dysfunction. Compared with an age-matched control population, plasma concentrations of phosphate and PTH were significantly higher and 1,25(OH)2D3 concentrations were significantly lower in the two groups of cats presenting with clinical signs of CRF. Significant ionised hypocalcaemia was present only in cats with end-stage renal failure. However, a number of cats were hyperparathyroid in the absence of abnormalities in the parameters of calcium homeostasis measured in this study. There was a significant correlation between plasma phosphate and PTH concentrations.
Concordant memory design using statistical integration for the billions-transistor era (2005)

An embedded DRAM macro in a logic compatible 90nm CMOS process is designed with low-noise core architecture and high-accuracy post-fabrication tuning. With a 5fF/cell capacitance, a 61% improvement of sensing accuracy enables 322MHz random-cycle operation and reduces data retention power to 60 /spl mu/W.
Regulation of the Phagocyte Respiratory Burst Oxidase by Protein Interactions (2000)

The activity of the phagocyte respiratory burst oxidase is regulated by complex and dynamic alterations in proteinprotein interactions that result in the rapid assembly of an active multicomponent NADPH oxidase enzyme on the plasma membrane. While the enzymatic activity has been studied for the past 20 years, the past decade has seen remarkable progress in our understanding of the enzyme and its activation at the molecular level. This article describes the current state of knowledge, and proposes a model for the mechanism by which protein-protein interactions regulate enzyme activity in this system.
Distributed Alarming in the On-Duty and Off-Duty Models (2014)

Decentralized monitoring and alarming systems can be an attractive alternative to centralized architectures. Distributed sensor nodes (e.g., in the smart grid's distribution network) are closer to an observed event than a global and remote observer or controller. This improves the visibility and response time of the system. Moreover, in a distributed system, local problems may also be handled locally and without overloading the communication network. This paper studies alarming from a distributed computing perspective and for two fundamentally different scenarios: on-duty and off-duty. We model the alarming system as a sensor network consisting of a set of distributed nodes performing local measurements to sense events. In order to avoid false alarms, the sensor nodes cooperate and only escalate an event (i.e., raise an alarm) if the number of sensor nodes sensing an event exceeds a certain threshold. In the on-duty scenario, nodes not affected by the event can actively help in the communication process, while in the off-duty scenario, non-event nodes are inactive. We present and analyze algorithms that minimize the reaction time of the monitoring system while avoiding unnecessary message transmissions. We investigate time and message complexity tradeoffs in different settings, and also shed light on the optimality of our algorithms by deriving cost lower bounds for distributed alarming systems.
Supplementary Table S1 from A Combinatorial CRISPR–Cas9 Screen Identifies Ifenprodil as an Adjunct to Sorafenib for Liver Cancer Treatment (2023)

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Livestock genetic origins: Goats buck the trend (2001)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Numerical Analysis of Deposition Rates of Zirconium Thin Films by Thermal Chemical Vapor Deposition (1992)

Zirconia films were prepared by the CVD method using thermal decomposition of zirconium-tetra-i-propoxide with He gas under 20kPa. The films on the substrate consisted of fine particles less than 1μm and were metastable tetragonal-zirconia. The maximum deposition rate was 6nm/s at 673K and a reactant gas concentration of 0.05mol%. The profile of deposition rate was calculated using a simplified reaction and coagulation model. The calculated results showed a good agreement with the experimental data under the operating conditions of 673K and 0.07mol%. Deposition rates for the system used are estimated with this model.
Transient Polycomb activity represses developmental genes in growing oocytes (2022)

Abstract Background Non-genetic disease inheritance and offspring phenotype is substantially influenced by germline epigenetic programming, including genomic imprinting. Loss of Polycomb Repressive Complex 2 (PRC2) function in oocytes causes non-genetically inherited effects on offspring, including embryonic growth restriction followed by post-natal offspring overgrowth. While PRC2 dependent non-canonical imprinting is likely to contribute, less is known about germline epigenetic programming of non-imprinted genes during oocyte growth. In addition, de novo germline mutations in genes encoding PRC2 lead to overgrowth syndromes in human patients, but the extent to which PRC2 activity is conserved in human oocytes is poorly understood. Results In this study we identify a discrete period of early oocyte growth during which PRC2 is expressed in mouse growing oocytes. Deletion of Eed during this window led to the de-repression of 343 genes. A high proportion of these were developmental regulators, and the vast majority were not imprinted genes. Many of the de-repressed genes were also marked by the PRC2-dependent epigenetic modification histone 3 lysine 27 trimethylation (H3K27me3) in primary-secondary mouse oocytes, at a time concurrent with PRC2 expression. In addition, we found H3K27me3 was also enriched on many of these genes by the germinal vesicle (GV) stage in human oocytes, strongly indicating that this PRC2 function is conserved in the human germline. However, while the 343 genes were de-repressed in mouse oocytes lacking EED, they were not de-repressed in pre-implantation embryos and lost H3K27me3 during pre-implantation development. This implies that H3K27me3 is a transient feature that represses a wide range of genes in oocytes. Conclusions Together, these data indicate that EED has spatially and temporally distinct functions in the female germline to repress a wide range of developmentally important genes, and that this activity is conserved in the mouse and human germlines.
Strong Interaction. By Thomas Spence Smith. University of Chicago Press, 1993. 315 pp. $39.95 (1994)

Strong Interaction.By Thomas Spence Smith. University of Chicago Press, 1993. 315 pp. $39.95 Get access John R. Hall John R. Hall University of California, Davis Search for other works by this author on: Oxford Academic Google Scholar Social Forces, Volume 73, Issue 1, September 1994, Pages 319–321, https://doi.org/10.1093/sf/73.1.319 Published: 01 September 1994
Adaptive noise attenuation (2008)

The attenuation of noise that is generated from the near‐surface is a difficult goal to achieve in land data processing. However, some characteristics can be extracted from the input data itself to feed an adaptive filtering in order to remove “pseudo‐random” or coherent noise. Two complementary approaches are presented: the first approach is an adaptive automated frequency dependant amplitude threshold method to detect and remove high amplitude “pseudo‐random” and coherent noise. The second approach is an adaptive groundroll filtering performing an elastic modeling. Combining both approaches improves the efficiency removal of noise such as high amplitude aliased dispersive groundroll.
Assignment of New Facets Developing on {111} Surfaces of Vapor-Deposited Diamond Crystals (1991)

The morphology of diamond particles synthesized by hot-filament chemical vapor deposition have been studied for assignment of the new and flat surfaces developing on rough {111} surfaces of a cubo-octahedron with the increase of crystal size. The new surfaces are assigned to {100} according to the interplanar angle with {100} surfaces of a cubo-octahedron, its smoothness, and the maintenance of the original cubo-octahedron shape with the increase of size, which have been observed by a scanning electron microscope.
Rheological studies on specific ion forms of ι‐carrageenate gels (1981)

Abstract Measurements have been made of the shear modulus for calcium, potassium and sodium ι‐carrageenate gels as a function of biopolymer concentration and temperature. The results are discussed in terms of the application of rubber elasticity theory. Calcium ι‐carrageenate gels appear to possess a random glass‐like structure whereas both sodium and potassium ι‐carrageenate gels form a pseudocrystalline structure. These differences are tentatively attributed to differences in the solubility of the salt forms which, through controlling the gelation temperature, moderate the kinetics of the gelation process.
Sentinel Lymph Node Biopsy in Breast Cancer: Guidelines and Pitfalls of Lymphoscintigraphy and Gamma Probe Detection (1998)

There are certain guidelines for performing SN biopsy by lymphoscintigraphy and gamma probe detection. Success depends primarily on an adequate functional capacity of the SN, necessary for sufficient nodal uptake to ensure accurate identification. Lymphoscintigraphy defines the pattern of lymph flow and may prevent failure or false-negative biopsies. Biopsy of the SN is a highly accurate, minimally invasive method of staging patients with breast cancer and can substantially reduce the morbidity and costs of surgical treatment by avoiding unnecessary ALND in the majority of patients.
Intravitreal Expansion of Perfluorocarbon Bubbles (1980)

The intraocular expansion of perfluoromethane (CF4), perfluoroethane (C2F6), and perfluoropropane (C3F8) was determined by a direct method for measuring intravitreal gas. A bubble of CF4 was found to expand 1.9 times the volume initially injected; C2F6 expanded 3.3 times; C3F8 expanded four times. The expansion characteristics of the experimental gases were compared with those of sulfur hexafluoride (SF6) and octofluorocyclobutane (C4F8), two gases already in clinical use.
Copper–Phthalocyanine Conjugates of Serum Albumins as Enantioselective Catalysts in Diels–Alder Reactions (2006)

Chiralität aus dem Blut: Die Bildung stabiler Komplexe aus Serumalbuminen und Kupfer(II)-phthalocyaninen führt zu Proteinkonjugaten. Diese Hybridkatalysatoren ermöglichen enantioselektive Diels-Alder-Reaktionen: Beispielsweise werden aus Azachalconen 1 und Cyclopentadien (2) die Produkte 3 mit 85–98 % ee erhalten.
Goniotomy with a single-use dual blade: Short-term results (2017)

Single-use dual blade goniotomy plus phacoemulsification resulted in a significant and sustained reduction in IOP and a decrease in glaucoma medications after 6 months of follow-up.
Effect of a novel kappa-receptor agonist, nalfurafine hydrochloride, on severe itch in 337 haemodialysis patients: a Phase III, randomized, double-blind, placebo-controlled study (2009)

This Phase III, randomized, double-blind, placebo-controlled, parallel-group, prospective study based on VAS evaluations clearly showed that orally taken nalfurafine hydrochloride effectively reduced itches that were otherwise refractory to currently available treatments in maintenance haemodialysis patients, with few significant ADRs. This novel drug was officially approved for clinical use in January 2009 by the Ministry of Health, Labour and Welfare of Japan.
The pathophysiology of disc degeneration (2008)

The pathophysiology of intervertebral disc degeneration has been extensively studied. Various factors have been suggested as influencing its aetiology, including mechanical factors, such as compressive loading, shear stress and vibration, as well as ageing, genetic, systemic and toxic factors, which can lead to degeneration of the disc through biochemical reactions. How are these factors linked? What is their individual importance? There is no clear evidence indicating whether ageing in the presence of repetitive injury or repetitive injury in the absence of ageing plays a greater role in the degenerative process. Mechanical factors can trigger biochemical reactions which, in turn, may promote the normal biological changes of ageing, which can also be accelerated by genetic factors. Degradation of the molecular structure of the disc during ageing renders it more susceptible to superimposed mechanical injuries. This review supports the theory that degeneration of the disc has a complex multifactorial aetiology. Which factors initiate the events in the degenerative cascade is a question that remains unanswered, but most evidence points to an age-related process influenced primarily by mechanical and genetic factors.
Human-UAV Teaming in Dynamic and Uncertain Environments (2018)

In this demonstrator we show how an algorithm developed for human-agent coordination can be used to coordinate human actors on the ground and unmanned aerial vehicles in a rescue mission. A video can be found here: http://goo.gl/QLQD7q.
Algorithm 650 (1987)

Two square root algorithms (for integer and floating point data types) are presented, which are simpler and more efficient than standard procedures. These could be effectively used as the basis of hardware-based square root generators as well as for software implementations. One possible appli- cation for an efficient square root routine would be in calculating trigonometric and exponential functions. (This application may be primarily of academic interest, however, since standard tran- scendental function generators would generally be more efficient.) Three accompanying MC68000 implementations of the algorithm for 32-bit integer and IEEE single- and double-precision data are available on the CALGO listing. These programs return rounding status in the condition code register, and they exhibit the following approximate runtime performance at 8 MHz: 105-134 ps (integer); 180-222 ps (single precision); 558-652 ps (double precision).
Psychological Change in Neurotic Depression: A Repertory Grid and Personal Construct Theory Approach (1981)

Personal construct theory and repertory grid methodology were applied to a study of psychological change experienced by a sample of ten neurotic depressives and their matched controls during short-term hospitalization. All subjects completed a repertory grid and the Zung depression scale on admission to hospital. Depressives were characterized by lower self-esteem, more negative social perception and higher scores on the Zung scale. Both measures were repeated at the time of discharge from hospital. Depressives showed a significant reduction in depressive mood, more positive social perception, and a change in th construing of the self; controls showed no changes. It is argued that the use of a quantitative assessment technique reinforced by a theoretical framework results in a more refined understanding of psychological change.
Chromatographic and antigenic properties of Echinococcus granulosus hydatid cyst‐derived glycolipids (1993)

The neutral and acidic fraction glycolipids of Echinococcus granulosus metacestode tissue compartments were isolated, defined by their chromatographic and antigenic properties, and assessed as to their efficacy as antigens in the serodiagnosis of human hepatic cystic and alveolar echinococcosis, and other helminthiases. Analyses were accomplished by thin-layer chromatography immunostaining and ELISA. The neutral glycolipid fraction's major carbohydrate epitope was the same as or very similar to that of Taenia crassiceps neutral glyco(sphingo)lipids, as represented by the 'neogala'-series core structure. The blood group-active, carbohydrate epitope P1 was expressed by a number of neutral fraction glycolipid component bands. The reverse-phase, thin-layer chromatography-isolated neutral fraction glycolipid component, designated Ag1, was efficient in the serological discrimination of cystic echinococcosis medium to high-titred sera. Ag1 did not specifically discriminate low-titred sera, i.e., other human helminthiases. The detected sialic acid residues of the acidic fraction glycolipids, on enzymatic cleavage, were identified as N-acylneuraminic acid and terminal. The acidic fraction glycolipids exhibited the paradox of only chemically minor components being antigenic towards cystic and alveolar echinococcosis infection sera. The combined acidic fraction glycolipid components Ra and Rx were capable of serological discrimination between cystic echinococcosis, alveolar echinococcosis and other helminthiases.
Database replication techniques: a three parameter classification (2002)

Data replication is an increasingly important topic as databases are more and more deployed over clusters of workstations. One of the challenges in database replication is to introduce replication without severely affecting performance. Because of this difficulty, current database products use lazy replication, which is very efficient but can compromise consistency. As an alternative, eager replication guarantees consistency but most existing protocols have a prohibitive cost. In order to clarify the current state of the art and open up new avenues for research, this paper analyses existing eager techniques using three key parameters (server architecture, server interaction and transaction termination). In our analysis, we distinguish eight classes of eager replication protocols and, for each category, discuss its requirements, capabilities and cost. The contribution lies in showing when eager replication is feasible and in spelling out the different aspects a database replication protocol must account for.
ChemInform Abstract: Crystallization of Lanthanoid‐Doped YBa2Cu3O7‐δ Ceramics as a Method for Preparing Yttrium‐Containing High‐Tc Superconductors with High Critical Current Densities. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Fluorescence Lifetime Techniques in Multimodal Tissue Diagnostic Platform (2011)

We overview fluorescence lifetime techniques for tissue diagnostics and approaches to merging these techniques with ultrasound backscatter microscopy and photoacoustic imaging. Such hybrid system allow for complex tissue characterization at biochemical, morphological, and functional levels.
D-dimer testing as an adjunct to ultrasonography in patients with clinically suspected deep vein thrombosis: prospective cohort study (1998)

Testing for D-dimer as an adjunct to a normal baseline ultrasound examination decreased the number of subsequent ultrasound examinations considerably without any increased risk of venous thromboembolic complications in patients not receiving anticoagulants. The use of ultrasound and testing for D-dimer enabled treatment decisions to be made at the time of presentation in most patients.
Lyophilization of premixed COVID‐19 diagnostic RT‐qPCR reactions enables stable long‐term storage at elevated temperature (2021)

Reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR) diagnostic tests for SARS-CoV-2 are the cornerstone of the global testing infrastructure. However, these tests require cold-chain shipping to distribute, and the labor of skilled technicians to assemble reactions and interpret the results. Strategies to reduce shipping and labor costs at the point-of-care could aid in diagnostic testing scale-up and response to the COVID-19 outbreak, as well as in future outbreaks. In this study we test both lab-developed and commercial SARS-CoV-2 diagnostic RT-qPCR mixes for the ability to be stabilized against elevated temperature by lyophilization. Fully assembled reactions were lyophilized and stored for up to a month at ambient or elevated temperature and were subsequently assayed for their ability to detect dilutions of synthetic SARS-CoV-2 RNA. Of the mixes tested, we show that one commercial mix can maintain activity and sensitivity after storage for at least 30 days at ambient temperature after lyophilization. We also demonstrate that lyoprotectants such as disaccharides can stabilize freeze-dried diagnostic reactions against elevated temperatures (up to 50°C) for at least 30 days. We anticipate that the incorporation of these methods into SARS-CoV-2 diagnostic testing will improve testing pipelines by reducing labor at the testing facility and eliminating the need for cold-chain shipping.
Biomechanical testing of hamstring graft tibial tunnel fixation with bioabsorbable interference screws (2003)

Fixation using a single tapered 35-mm screw displayed increased maximum load at failure compared with the 28-mm screw or bicortical fixation. Both the tapered 35-mm screw and bicortical fixation showed greater stiffness than fixation using a 28-mm screw. Use of a single 35-mm screw for quadrupled hamstring graft-tibial tunnel fixation may be preferred for patients with poor tibial BMD.
Cyclosporin A-induced hair growth in mice is associated with inhibition of calcineurin-dependent activation of NFAT in follicular keratinocytes (2003)

One of the most common side effects of treatment with cyclosporin A (CsA) is hypertrichosis. This study shows that calcineurin activity is associated with hair keratinocyte differentiation in vivo, affecting nuclear factor of activated T cells (NFAT1) activity in these cells. Treatment of nude or C57BL/6 depilated normal mice with CsA inhibited the expression of keratinocyte terminal differentiation markers associated with catagen, along with the inhibition of calcineurin and NFAT1 nuclear translocation. This was associated with induction of hair growth in nude mice and retardation of spontaneous catagen induction in depilated normal mice. Furthermore, calcineurin inhibition blocked the expression of p21(waf/cip1) and p27(kip1), which are usually induced with differentiation. This was also associated with an increase in interleukin-1alpha expression (nude mice), a decrease in transforming growth factor-beta (nude and normal mice), and no change in keratinocyte growth factor expression in the skin. Retardation of catagen in CsA-treated mice was accompanied by significant alterations in apoptosis-related gene product expression in hair follicle keratinocytes. The ratio of the anti-apoptotic Bcl-2 to proapoptotic Bax expression increased, and expression of p53 and interleukin-1beta converting enzyme activity decreased. These data provide the first evidence that calcineurin is functionally active in follicular keratinocytes and that inhibition of the calcineurin-NFAT1 pathway in these cells in vivo by CsA enhances hair growth.