gebhart/patrepeval huggingface dataset:
Semisupervised Federated-Learning-Based Intrusion Detection Method for Internet of Things (2022)

Federated learning (FL) has become an increasingly popular solution for intrusion detection to avoid data privacy leakage in Internet of Things (IoT) edge devices. Existing FL-based intrusion detection methods, however, suffer from three limitations: 1) model parameters transmitted in each round may be used to recover private data, which leads to security risks; 2) not independent and identically distributed (non-IID) private data seriously adversely affect the training of FL (especially distillation-based FL); and 3) high communication overhead caused by the large model size greatly hinders the actual deployment of the solution. To address these problems, this article develops an intrusion detection method based on a semisupervised FL scheme via knowledge distillation. First, our proposed method leverages unlabeled data via distillation method to enhance the classifier performance. Second, we build a model based on convolutional neural networks (CNNs) for extracting deep features of the traffic packets, and take this model as both the classifier network and discriminator network. Third, the discriminator is designed to improve the quality of each client’s predicted labels, and to avoid the failure of distillation training caused by a large number of incorrect predictions under private non-IID data. Moreover, the combination of the hard-label strategy and voting mechanism further reduces communication overhead. The experiments on the real-world traffic data set with three non-IID scenarios show that our proposed method can achieve better detection performance as well as lower communication overhead than state-of-the-art methods.
Transcription of the Gene for a Pepsinogen, PEP1, Is Regulated by White-Opaque Switching in Candida albicans (1992)

Cells of Candida albicans WO-1 spontaneously switch between a white and opaque CFU, and this phase transition involves a dramatic change in cellular phenotype. By using a differential hybridization screen, an opaque-specific cDNA, Op1a, which represents the transcript of a gene regulated by switching, has been isolated. The gene for Op1a is transcribed by opaque but not by white cells. The nucleotide sequence of the Op1a cDNA reveals over 99% base homology with an acid protease gene of C. albicans, and the predicted amino acid sequence demonstrates that the product of this gene is a member of the family of pepsinogens, which possess a hydrophobic leader sequence for secretion and two catalytic aspartate domains. Southern blots of both genomic DNA digested with 14 different endonucleases and electrophoretically separated chromosomes were probed with the Op1a cDNA. No polymorphisms were detected in either case between white and opaque cells, suggesting that no genomic reorganization occurs in the proximity of the gene during the white-opaque transition. Although transcription of Op1a correlates with the high levels of extracellular protease activity in opaque cell cultures and the absence of activity in white cell cultures, stimulation of extracellular protease activity by addition of serum albumin is not accompanied by Op1a transcription in cultures of WO-1 white cells or cultures of two additional clinical isolates of C. albicans, suggesting that expression of one or more other protease genes is stimulated in these cases. The results demonstrate that transcription of the Op1a gene is under the rigid control of switching in strain WO-1.
Cytotoxic Activities of Normal Cultured Human T Cells (1978)

Normal human T cells grown in continued cultures in medium containing conditioned medium (CM) from PHA-stimulated lymphocytes were studied for their ability to manifest three known forms of cell-mediated cytotoxicity: lectin-induced cellular cytotoxicity (LICC), natural killer cell (NK) activity, and antibody-dependent cellular cytotoxicity (ADCC). The cultured T cells (CTC) were very effective mediators of LICC, being cytotoxic even at very low attacker-target cell ratios in the presence of different lectins, and against different types of targets. When tested without the addition of lectin, the CTC demonstrated a low degree of spontaneous cytotoxicity. This spontaneous cytotoxicity might not be due to conventional NK cells however, since the CTC failed to show significant numbers of cells with Fc receptors (FcR) for IgG, and had no detectable ADCC activity. CTC could represent a population enriched in polyclonal activated T cells with low spontaneous cytotoxicity against a variety of allogeneic target cells, which is greatly enhanced by the addition of lectins dur ing the 51Cr release assay.
Wet Cleaning of Cross-Contamination of High-k Dielectrics in Plasma Etch Tool (2006)

Direct tunneling through the gate has become a serious concern for metal-oxide semiconductor field effect transistor scaling. The semiconductor industry is focusing on dielectrics with high relative dielectric constants to replace gate oxides. Among the potential high- materials, oxides and silicates of hafnium (Hf) have shown the most promise. The possibility of process cross-contamination by integrating these materials into silicon processes is a major concern for integrated circuit manufacturers. Cross-contamination of Hf in a plasma etch tool has been investigated. These studies confirm that significant cross-contamination occurs when is etched in a chloro-fluoro-carbon plasma etch system. None of the standard cleaning processes commonly used in the semiconductor industry (such as SC1 and SC2) completely remove the contamination; however, dilute hydrofluoric acid, hydrofluoric acid-hydrogen peroxide water mixture, and SC1 cleans removed contamination below the concentration thresholds for oxide degradation and close to the total reflection X-ray fluorescence detection limit.
Nimble: Efficiently Compiling Dynamic Neural Networks for Model Inference (2020)

Modern deep neural networks increasingly make use of features such as dynamic control flow, data structures and dynamic tensor shapes. Existing deep learning systems focus on optimizing and executing static neural networks which assume a pre-determined model architecture and input data shapes--assumptions which are violated by dynamic neural networks. Therefore, executing dynamic models with deep learning systems is currently both inflexible and sub-optimal, if not impossible. Optimizing dynamic neural networks is more challenging than static neural networks; optimizations must consider all possible execution paths and tensor shapes. This paper proposes Nimble, a high-performance and flexible system to optimize, compile, and execute dynamic neural networks on multiple platforms. Nimble handles model dynamism by introducing a dynamic type system, a set of dynamism-oriented optimizations, and a light-weight virtual machine runtime. Our evaluation demonstrates that Nimble outperforms state-of-the-art deep learning frameworks and runtime systems for dynamic neural networks by up to 20x on hardware platforms including Intel CPUs, ARM CPUs, and Nvidia GPUs.
A Robust Power Management Strategy With Multi-Mode Control Features for an Integrated PV and Energy Storage System to Take the Advantage of ToU Electricity Pricing (2018)

In this paper, a power management strategy (PMS) for an integrated residential solar photovoltaic (PV) and energy storage unit (ESU) is proposed for both grid-connected and islanded operations to take the advantage of time-of-use pricing. This is an effective solution to integrate storage and renewable energy sources, such as solar PV, with the conventional grid to improve the reliability and efficiency of the power system and to reduce the total electricity cost for the consumer. An automatic switching control strategy is proposed to realize a smooth switching among the various operation modes of the proposed energy management strategy. The integrated PV-storage system is composed of a 5-kW PV array, a 3.5-kW·h ESU formed by 12-V single lead acid batteries, and three power converters. The PMS ensures seamless switching of the ESU converter between the charging and the discharging mode and seamless switching between the inverting and the rectifying mode of the grid converter. It also ensures that the local loads are supplied when the grid fails. An experimental setup has been implemented in the laboratory using the real-time field-programmable gate array general-purpose inverter control card from National Instrument to verify the practical feasibility of the proposed PMS under the various scenarios of the PV irradiation, load changings, and the state of charge of the ESU. The results show that the proposed PMS is effective and robust against various scenarios.
Supplementary Fig. S1 from EBP1, an ErbB3-binding protein, is decreased in prostate cancer and implicated in hormone resistance (2023)

Supplementary Fig. S1 from EBP1, an ErbB3-binding protein, is decreased in prostate cancer and implicated in hormone resistance
Malaria risk factors in an endemic region of Sri Lanka, and the impact and cost implications of risk factor-based interventions. (1998)

In an 18-month study of malaria in a population of 1,875 residents in 423 houses in an endemic area in southern Sri Lanka, the risk of malaria was found to be 2.5-fold higher in residents of poorly constructed houses than in those living in houses of good construction type. In residents of poorly constructed houses but not in others, the risk was even greater when the house was located near a source of water that could act as a potential breeding place for malaria vector mosquitoes (P = 0.0001). Based on previous findings that confirmed that house construction type was itself a risk determinant, and not merely a marker of other behavioral factors, we have estimated the potential impact of two feasible interventions to reduce the risk of malaria: 1) the imposition of a buffer zone of 200 meters around bodies of water from which houses of poor construction were excluded, which was estimated to lead to a 21% reduction of the malaria incidence in the overall population and a 43% reduction in the relocated community; and 2) the conversion of houses of poor construction type located in the buffer zone to those of a good construction type, which was estimated to lead to a 36% reduction in the incidence rates in the whole population and a 76% reduction in the residents of houses whose construction type was improved. Taking into consideration the cost to the Government of malaria prevention, we estimated the worth of a Government's investment in improving house construction type. The investment in housing was estimated to be offset in 7.2 years by savings to the Government on malaria costs alone, and beyond this period, to bring a return on the Government's investment by way of savings to the malaria control program.
Micro-Sized Cold Atmospheric Plasma Source for Brain and Breast Cancer Treatment (2018)

Micro-sized cold atmospheric plasma ( CAP) has been developed to expand the applications of CAP in cancer therapy. In this paper, cancer cells. Various diagnostic techniques were employed to evaluate the parameters of CAP optical emission spectroscopy. The generation of short-and long-lived species (such as hydroxyl radical [OH], superoxide [O 2 2 O 2 ], and nitrite [NO 2 These data revealed that species generated by to tumor cell type.
[Epidemiology of cerebral cysticercosis in an Andean community in Ecuador]. (1999)

Taenia solium neurocysticercosis (NCC) has been documented to be an underlying cause of epilepsy, intractable headaches, hydrocephalus, dementia and other serious neurological conditions in many countries of Central and South America. However, methodological limitations had prevented the assessment of the true prevalence of this condition at the community level. We conducted a house-to-house neuroepidemiological survey of 6,118 residents of an Andean community. This information was used to target neuroimaging (CT-scan) and immunodiagnosis (enzyme-linked immunoelectrotransfer blot assay, EITB) tests in individuals suspected of harbouring Taenia solium NCC. In the rural population, NCC was confirmed in 8 out of 47 examined by CT-scan (17%) and in 6 of 42 examined by EITB (14%). In the urban population, NCC was confirmed in 35 of 147 examined by CT-scan (23.8%) and in 28 of 124 examined by EITB (22.6%). In a sample of relatives of patients with documented cerebral cysticercosis, 20 out of 81 examined by CT-scan (25%) and 12 of 79 (15%) examined by EITB had NCC. Finally, CT scans were performed for 83 school children from urban areas, and 9 (11%) were diagnosed as harbouring NCC. In a community-based study, cysticercosis appears to be much more frequent than initially thought, when CT examination is used as the "gold standard" for diagnosis.
Prophylaxis of Plasmodium falciparum Infection in a Human Challenge Model with WR 238605, a New 8-Aminoquinoline Antimalarial (1998)

The prophylactic efficacy of WR 238605, a primaquine analog, was studied with a human Plasmodium falciparum challenge model. A single oral dose of 600 mg, administered 1 day prior to challenge, successfully protected three of four subjects. The fourth subject developed mild, oligosymptomatic malaria on day 31, with drug concentrations one-half of those in the protected individuals. WR 238605 appears to be a promising prophylactic drug for P. falciparum malaria.
All things mucosal (2009)

The first conference on 'Modern Mucosal Vaccines, Adjuvants and Microbicides' took place on 22-24 October 2008 in Oporto, Portugal. The scientific program was wide-ranging and covered many diverse aspects of progress in human mucosal vaccines, including development, considerations of vaccine administration routes and mucosal adjuvants. Befiting the theme of the conference, there were also several presentations devoted to the development of mucosal microbicides.
Psychosocial Safety and Health Hazards and Their Impacts on Offshore Oil and Gas Installations (2023)

The offshore oil and gas working environment is an inherently dangerous one, with risks posed to physical safety on a daily basis. One neglected field of research is the added psychosocial stressors present in this environment. This research examined the experiences of offshore oil and gas workers through one-on-one online interviews which were recorded and transcribed. Transcripts were analysed through qualitative software NVivo, which generated themes and patterns for the responses given to questions which were developed through a focus group. The results of the analysis showed that multiple psychosocial stressors are present for this population, such as fear of speaking up, unsatisfactory company-provided facilities, work-life interference, work status, micromanaging, gender harassment and bullying. In addition, interviews identified that production and time pressures along with fatigue can influence accidents and mistakes. Climate factors also cause discomfort, however these are managed according to best practice by organisations. Due to the timing of the study, COVID-19 was a significant stressor for some, but not all, employees. In conclusion, offshore oil and gas workers face multiple stressors in a dangerous environment that may lead to devastating consequences.
The effect of body mass index on efficacy and safety of bosutinib or imatinib in patients with newly diagnosed chronic myeloid leukemia. (2021)

7037 Background: Bosutinib (BOS) is approved for the treatment (Tx) of Philadelphia chromosome–positive (Ph+) chronic myeloid leukemia (CML) resistant/intolerant to prior therapy and newly diagnosed Ph+ chronic phase (CP) CML. Body mass index (BMI) was shown to influence Tx response with front-line dasatinib vs imatinib (IMA). We report the efficacy and safety of BOS and IMA by BMI in patients (pts) with newly diagnosed CP CML. Methods: In the open-label BFORE trial, pts were randomized to receive 400 mg once daily BOS or IMA. Outcomes were assessed according to baseline BMI ≥25 or = 25 kg/m 2 . This post hoc analysis was based on the final 5-y analysis (database lock: June 12, 2020). Results: In the BOS and IMA arms, respectively, 149 (56.4%) vs 115 (43.6%) pts and 145 (54.3%) vs 122 (45.7%) pts had BMI ≥25 vs = 25. In both the BOS and IMA arms, median Tx duration and time on study was 55 mo for pts with BMI ≥25 or = 25; respective median dose intensity was 394 vs 393 mg/d and 400 vs 400 mg/d. Molecular response (MR) rates are shown in the table. Cumulative incidence of major MR was similar in pts with ≥25 vs = 25 receiving BOS (HR 0.99; 95% CI 0.74−1.31) or IMA (HR 1.09; 95% CI 0.81−1.47). Event-free survival (EFS) and overall survival (OS) rates at 60 mo are shown in the table. Most common reasons for Tx discontinuation were adverse events (AEs) (BOS 28.2 vs 20.0%; IMA 13.3 vs 10.7%) and lack of efficacy (BOS 5.4 vs 5.2%; IMA 16.1 vs 19.8%). In pts with BMI ≥25 vs = 25, dose reductions and interruptions due to Tx-emergent AEs (TEAEs) occurred in 43.6 % vs 46.2% and 66.4% vs 69.7% of pts with BOS and 24.5% vs 24.6% and 40.6% vs 50.8% with IMA. Any grade TEAEs in ≥30% of pts with BMI ≥25 vs = 25 were diarrhea (73.8 vs 73.1%), nausea (40.9 vs 31.9%), thrombocytopenia (30.9 vs 41.2%), increased alanine (37.6 vs 28.6%) and aspartate aminotransferase (30.2 vs 20.2%) with BOS and diarrhea (49.0 vs 29.5%), nausea (46.2 vs 37.7%), muscle spasms (33.6 vs 26.2%), neutropenia (14.7 vs 32.0%) and thrombocytopenia (10.5% vs 30.3%) with IMA. Conclusions: Efficacy of BOS was consistent in pts with BMI ≥25 or = 25; however, with IMA a low (vs high) BMI appeared to be associated with worse survival outcomes. Differences in certain TEAEs were observed between BMI subgroups in both treatment arms. Clinical trial information: NCT02130557. [Table: see text]
Noise2Recon: A Semi-Supervised Framework for Joint MRI Reconstruction and Denoising. (2021)

Deep learning (DL) has shown promise for faster, high quality accelerated MRI reconstruction. However, standard supervised DL methods depend on extensive amounts of fully-sampled ground-truth data and are sensitive to out-of-distribution (OOD) shifts, in particular for low signal-to-noise ratio (SNR) acquisitions. To alleviate this challenge, we propose a semi-supervised, consistency-based framework (termed Noise2Recon) for joint MR reconstruction and denoising. Our method enables the usage of a limited number of fully-sampled and a large number of undersampled-only scans. We compare our method to augmentation-based supervised techniques and fine-tuned denoisers. Results demonstrate that even with minimal ground-truth data, Noise2Recon (1) achieves high performance on in-distribution (low-noise) scans and (2) improves generalizability to OOD, noisy scans.
Rod photoreceptors in infant rats with a history of oxygen exposure. (1999)

Attenuation of the rod photoresponse parameters does not result simply from shortening of the outer segments and consequent low rhodopsin content. Rather, the structure of the outer segments is altered. A fault in the synthesis of the outer segments, rather than disposal of outer segment discs, is suspected.
The rumen and potassium homeostasis: a model (2007)

The ruminant has to be able to regulate potassium metabolism over an extremely wide range of intake. When related to body weight, dietary potassium intake of ruminants frequently exceeds that of humans by a factor of over ten, and experimental situations suggest that the toxic threshold for ingestion of potassium is considerably higher. While a number of studies have addressed the outstanding ability of the ruminant kidney to extrude potassium, the role of the rumen in maintaining potassium homeostasis in sheep and cows by serving as a reservoir for the redistribution of potassium has received considerably less attention. Based on current and past studies at the level of the cell, the tissue and the animal, we present a model for the regulation of ruminal transport that may help in the understanding of the variable responses of the rumen epithelium to dietary potassium intake, and the role of magnesium in mediating these responses.
The Power of Language (2012)

This is a transcript of the 2011 Undergraduate Convocation ceremony speech given by Shanti Bruce, recipient of the 2011 Farquhar College of Arts and Sciences Full-Time Faculty Excellence in Teaching Award, to welcome students and introduce the college theme.
One Class Support Vector Machines for audio abnormal events detection (2011)

This paper proposes an unsupervised method for real time detection of abnormal events in the context of audio surveillance. Based on training a One-Class Support Vector Machine (OC-SVM) to model the distribution of the normality (ambience), we propose to construct sets of decision functions. This allows controlling the trade-off between false-alarm and miss probabilities without modifying the trained OC-SVM that best capture the ambience boundaries, or its hyperparameters. Then we present an adaptive online scheme of temporal integration of the decision function output in order to increase performance and robustness. We also introduce a framework to generate databases based on real signals for the evaluation of audio surveillance systems. Finally, we present the performances obtained on the databases.
Hookworm-Related Anaemia among Pregnant Women: A Systematic Review (2008)

Evidence indicates that increasing hookworm infection intensity is associated with lower haemoglobin levels in pregnant women in poor countries. There are insufficient data to quantify the benefits of deworming, and further studies are warranted. Given that between a quarter and a third of pregnant women in SSA are infected with hookworm and at risk of preventable hookworm-related anaemia, efforts should be made to increase the coverage of anthelmintic treatment among pregnant women.
Energetics of domain engineered rhombohedral ferroelectric single crystals (2017)

Domain engineered rhombohedral relaxor ferroelectric single crystals of PIN-PMN-PT have stable domain structures that increase the piezoelectric constants and reduce dielectric loss, yet modeling the energetics of the domain formation and evolution has proven challenging. In this work a 10th order Landau-Devonshire energy function has been developed that reproduces the dielectric, piezoelectric and ferroelectric properties of PIN-PMN-PT with a composition in the rhombohedral phase near MPB. The coercive field was used to set the saddle points in the energy function governing homogeneous polarization switching. The energy function was implemented in a phase field model to simulate domain wall formation and domain evolution under applied field. The domain wall motion reduces the coercive field in the heterogeneous switching case compared to the homogeneous switching case.
A model of enzyme adsorption and hydrolysis of microcrystalline cellulose with slow deactivation of the adsorbed enzyme (1988)

Reduction in the activity and the concentration of the adsorbed enzyme are noted in the experimental data. Two alternative mechanisms, inactivation of the adsorbed enzyme and mass transfer of the enzyme from the bulk solution to the solution within the cellulose fibril where the cellulase is assumed to be inactive, are used to represent the decline in activity. The decline in concentration of the adsorbed enzyme is represented by a modest product inhibition and, more importantly, the assumption that the concentration of the adsorption sites is proportional to the square of the remaining substrate concentration. Measurements of both adsorbed enzyme and product concentration over time are used in determining parameter values. The model is applied to a series of experiments having a 10-fold range of substrate concentration and to an experiment in which the product is removed continuously. For both deactivation mechanisms, a very good representation of product concentration (standard deviation 3.6%) is obtained over the full period (168 h) of hydrolysis; the representation of adsorbed enzyme is, however, less accurate (standard deviation 6.7-6.8%).