gebhart/patrepeval huggingface dataset:
Deep Grading based on Collective Artificial Intelligence for AD Diagnosis and Prognosis (2022)

Accurate diagnosis and prognosis of Alzheimer's disease are crucial to develop new therapies and reduce the associated costs. Recently, with the advances of convolutional neural networks, methods have been proposed to automate these two tasks using structural MRI. However, these methods often suffer from lack of interpretability, generalization, and can be limited in terms of performance. In this paper, we propose a novel deep framework designed to overcome these limitations. Our framework consists of two stages. In the first stage, we propose a deep grading model to extract meaningful features. To enhance the robustness of these features against domain shift, we introduce an innovative collective artificial intelligence strategy for training and evaluating steps. In the second stage, we use a graph convolutional neural network to better capture AD signatures. Our experiments based on 2074 subjects show the competitive performance of our deep framework compared to state-of-the-art methods on different datasets for both AD diagnosis and prognosis.
Multistability Analysis for Recurrent Neural Networks with Unsaturating Piecewise Linear Transfer Functions (2003)

Multistability is a property necessary in neural networks in order to enable certain applications (e.g., decision making), where monostable networks can be computationally restrictive. This article focuses on the analysis of multistability for a class of recurrent neural networks with unsaturating piecewise linear transfer functions. It deals fully with the three basic properties of a multistable network: boundedness, global attractivity, and complete convergence. This article makes the following contributions: conditions based on local inhibition are derived that guarantee boundedness of some multistable networks, conditions are established for global attractivity, bounds on global attractive sets are obtained, complete convergence conditions for the network are developed using novel energy-like functions, and simulation examples are employed to illustrate the theory thus developed.
160 Canadian TrueNTH Sexual Health and Rehabilitation eClinic (SHAReClinic) for Prostate Cancer Patients: Results of a Feasibility Study (2020)

Sexual dysfunction (SD) after prostate cancer (PC) has a significant negative impact on a patient’s health-related quality of life. The TrueNTH Sexual Health and Rehabilitation eClinic (SHAReClinic) is a Canadian online intervention for patients/couples seeking treatment for sexual dysfunction after treatment for localized PC. The SHAReClinic intervention involves six online clinic visits; one pretreatment and five follow-up visits over a one-year period post PC treatment. Components of SHAReClinic include tailored and structured educational modules, personalized support via an online sexual health counsellor, a virtual library, and tracking and feedback mechanisms for participants. The objectives of this study are: 1) to determine the acceptability, and 2) to inform the effectiveness of an online, biopsychosocial intervention (SHAReClinic) in treating sexual dysfunction and supporting intimacy maintenance following localized PC treatment. This single-arm, prospective feasibility study recruited participants from six healthcare institutions across Canada to enroll in SHAReClinic. Website usage and analytics were analyzed at the end of the study to assess intervention acceptability. Questionnaires were completed at pre-treatment, 6 weeks, 6 months, and 12 months post treatment to inform the intervention effectiveness. Outcome measures for sexual function included the Sexual Health Inventory for Men (SHIM), the Patient-Reported Outcome Measurement Information System (PROMIS)- Interest in Sexual Activity and Sexual Activities, and the sexual health questions of the Expanded Prostate Index Composite (EPIC). Sexual distress and relationship intimacy were measured using the Sexual Distress Scale (SDS) and the Miller Social Intimacy Scale (MSIS) questionnaires respectively. Descriptive statistics were used to summarize the data.
Frequency Selective Surface for Ultra-Wide Band Filtering and Shielding (2022)

A frequency selective surface for spatial filtering in the standardized Ultra-Wide Band (UWB) frequency range is proposed. A very large stop-band of 1.75-15.44 GHz has been obtained, with good polarization insensitivity and an angular stability of more than 60∘ and more than 50∘ in TE and TM incidence, respectively. Circuit models have been devised. The structure has been assessed by electromagnetic simulation and implemented on an FR4 substrate of 1.6 mm thickness, with an edge of the square-shaped unit cell of 15 mm. Tests in an anechoic chamber demonstrated good matching between simulation and experimental results and proper operation of the device.
Ultrafast and highly sensitive photodetectors fabricated on high-energy nitrogen-implanted GaAs (2003)

We have fabricated and tested metal–semiconductor–metal (MSM) photodetectors based on nitrogen-ion-implanted GaAs. Nitrogen ions with energy of 700 and 880 keV, respectively, were implanted into epitaxial GaAs films at an ion concentration of 3×1012 cm−2. Ti/Au MSM photodetectors with 1-μm-wide fingers were fabricated on top of the implanted GaAs. In comparison to low-temperature-grown GaAs photodetectors, produced in parallel in identical MSM geometry, the 880 keV N+-implanted photodetectors exhibited almost two orders of magnitude lower dark current (10 nA at 1 V bias) and the responsivity more than doubled (&amp;gt;20 mA/W at 20 V bias). Illumination with 100-fs-wide, 810 nm wavelength laser pulses, generated ∼2.5-ps-wide photoresponse signals with amplitudes as high as 2 V. The 2.5 ps relaxation time was the same for both the ion-implanted and low-temperature-grown devices and was limited by the MSM capacitance time constant.
Home Energy Article: A Systems Approach to RetrofittingResidential HVAC Systems (2005)

Over the past couple of years, a Best Practices Guideline for Residential HVAC Retrofits has been developed by the US Department of Energy (DOE) to provide guidance for contractors in performing whole house retrofits. Because of the strongly cost-limited nature of retrofits, combined with the wide range of existing home performance, the DOE guideline has several levels of retrofit packages depending on the level of intervention that a homeowner can afford, or is justified by the condition of the home and its HVAC system. The packages are pre-selected combinations of individual retrofit activities that provide simple whole house guidance for contractors. This guideline has been evaluated by potential users such as contractors and weatherization experts. Part of this evaluation included a field pilot study applying the guidelines to eight test houses. The application of the guidelines to these houses resulted in feedback that helped to update and improve the guidelines. In order to have an independent assessment of the guidelines, two of the houses were evaluated by an independent energy efficiency contractor. One of the test houses was chosen to be retrofitted and had the Best Practices Guideline diagnostic screening tests repeated after the retrofit to compare pre- and post-retrofit performance, as well as being the subject of extensive monitoring to determine the change in house performance due to the retrofit. More details of these test results and the application and development of the Retrofit Guide can be found in Walker [2003].
Lipid‐Derived flavors of legume protein products (1977)

Abstract and Summary Legumes contain unsaturated lipids that are susceptible to oxidative deterioration. Enzymic and non‐enzymic deterioration of these lipids results in the development of off‐flavors. The primary objective of this review is to summarize what is currently known about lipid‐derived flavors of soybeans and underblanched pea seeds (Pisum sativum). Identifying the numerous volatile compounds arising from breakdown of lipid hydroperoxides coupled with organoleptic evaluation defines the flavor problem. Major contributors to the green‐beaniness of soybeans were found to be 3‐ cis ‐hexenal, 2‐pentyl furan, and ethyl vinyl ketone. Oxidized phosphatidylchohnes cause some of the bitter taste. The interaction of lipid breakdown products with proteins, carbohydrates, and other constituents can affect flavor characteristics and also increase the problems of their removal from soy protein products. To prepare bland products, it will be necessary to develop processes that effectively remove bound flavor components and prevent formation of derived flavors. Solvent systems based on alcohol have been used to extract flavor principles from soybeans; aqueous alcohol treatment of the intact seed or blanching with hot water or steam inhibits formation of off‐flavors in peas and soybeans. A new approach involving infusion of antioxidants into the intact seed to control lipid deterioration during processing and storage is proposed to minimize flavor formation without subsequent undesirable changes in protein which occur with alcohol treatments.
Supplementary Figures 1-2, Supplementary Tables 1-2 from Multivalent Binding and Biomimetic Cell Rolling Improves the Sensitivity and Specificity of Circulating Tumor Cell Capture (2023)

&lt;p&gt;Table S1. Clinical and demographic characteristics of recruited cancer patients; Table S2. Demographic characteristics of recruited healthy donors; Figure S1. Reproducibility confirmation of CapioCyte-D by testing duplicated blood samples from three cancer patients (A-C) using separately prepared capture surfaces (slides 1 and 2); Figure S2. A comparison of the captured epithelial cell number from two healthy donor groups with different age ranges (under 35 years vs. above 50 years).&lt;/p&gt;
Química de complexos de (etilenodiaminatetraacetato)rutenato(III/II) (2004)

RUTHENIUM COMPLEXES CONTAINING ETHYLENEDIAMINETETRAACETATE. This paper provides a survey of general aspects involved in the coordination chemistry of low-valent (mainly +III,+II), low-spin (d 5 ,d 6 ) ruthenium ions with ethylenediamine-N,N,N',N'-tetraacetate (edta) and their substituted derivatives. The topics covered herein include structure, reactivity, kinetics, thermodynamics, electrochemistry and spectroscopy. The contributions from either our research group or the literature over the last three decades are focused in this review.
Unique Flow-Back Chemistry for Enhancing Productivity of Low- Permeability Reservoir (2012)

Abstract Low-permeability reservoirs are highly sensitive to water saturation. When filtrate or clear brine is lost into these formations, capillary forces pull the fluid into pore spaces and prevent full displacement upon production. This paper illustrates how effective flowback chemistry reduces water saturation and enhances productivity. The authors initiated a study to evaluate chemistries that can be added to reservoir drill-in fluids, completion brines, and workover fluids to reduce capillary forces, recover invaded brine from the formation, and promote optimal productivity of the well. This paper introduces a unique flowback chemistry that not only provides excellent surface tension reduction and good thermal stability, but fulfills a challenge not met before; i.e., it is completely soluble and compatible with all common types of completion brines. Furthermore, this chemistry is not absorptive to solids in drilling fluids or a porous formation matrix, therefore low surface tension and low capillary pressure are maintained with mud filtrate or brine that is lost to the formation. Simple, low-cost, and innovative methodologies are presented to illustrate capillary pressure reduction and brine recovery in a simulated formation. Due to the nature of surface activity, flowback treatments containing surfactants invariably generate strong and long-lived foam. If not controlled, foam can cause difficulties or even catastrophic outcomes for well service jobs including fluid transportation, well circulation, and brine reclamation. The flowback chemistry presented in this paper includes a new and very effective defoamer (or antifoamer,) which renders the flowback treatment non-foaming. Successful lab tests and field application are presented.
Chromatin Fine-Structure Mapping of the Goat βF Gene in Fetal Erythroid Tissue (1987)

Using a restriction enzyme accessibility assay, we have previously demonstrated that the chromatin structure immediately proximal to the goat beta F-, beta C-, and beta A-globin genes changes in a manner which parallels their developmentally regulated expression. More specifically, the PvuII recognition sequence, located 9 nucleotides upstream from the transcriptional start site in each of the three genes, is accessible to digestion only in nuclei prepared from erythroid tissue in which the respective gene product is expressed. Here we describe two restriction enzyme sites further upstream from the transcription start sites (HindIII at -700 and SacI at -480) which were not accessible to digestion in fetal erythroid nuclei. Conversely, two sites within the second coding block of the beta F gene (AccI at +276 and BamHI at +470) were accessible in fetal erythroid tissue. The corresponding sites in the beta C and beta A genes were not available for digestion in the same fetal tissue. Processive exonuclease III digestion in situ from the three accessible restriction enzyme sites in the beta F gene allowed us to define more closely the limits of these open regions. Resistance to exonuclease III digestion was encountered at or near both intron-exon junctions flanking the first intervening sequence of the beta F gene. Conversely, no resistance to exonuclease III digestion was evident in either the first or second coding blocks or the 5' untranslated region. Digestion upstream from the PvuII site of the beta F gene was negligible. High-resolution mapping by S1 nuclease analysis indicated that the endpoint of exonuclease III digestion from this site lay immediately downstream of the ATA box.
Effect of metformin on serum levels of leptin and adiponectin. (2015)

&lt;p&gt;Serum levels of leptin (A) and adiponectin (B) were measured by enzyme immunoassay. Values are the means ± SD. * &lt;i&gt;P&lt;/i&gt; &lt; 0.05.&lt;/p&gt;
Cerebral autoregulation following minor head injury (1997)

Artificial neural networks are used increasingly in applications such as graphic pattern recognition, which are difficult to address with conventional statistical methods. In the management of chronic pain, graphic methods are used routinely; patients describe their patterns of pain using "pain drawings." The authors have previously reported an automated, computerized pain drawing methodology, which has been used by patients with implanted spinal cord stimulators to represent a technical goal of the procedure, the overlap of pain by stimulation paresthesias. Standard linear discriminant statistical methods have shown associations between stimulation parameters and electrode positions as independent variables and technical outcome and relief of pain as dependent variables. The authors have applied artificial neural networks to the problem of optimizing implanted stimulator adjustment. A data set of 3000 electrode combinations obtained in 41 patients was used to develop a linear discriminant statistical model on a mainframe computer and to train artificial neural networks on a personal computer. The performance of these two systems on a new data set obtained in 10 patients was compared with that of human "experts." The best neural network model was marginally better than the linear discriminant model; the variance in patient ratings was predicted by these models to a degree that the human experts were unable to predict. The authors anticipate expanding the role of these models and incorporating them into expert systems for clinical use.
TA205, an anti‐talin monoclonal antibody, inhibits integrin–talin interaction (2006)

Talin mediates integrin signaling by binding to integrin cytoplasmic tails through its FERM domain which consists of F1, F2 and F3 subdomains. TA205, an anti-talin monoclonal antibody, disrupts actin stress fibers and focal adhesion when microinjected into fibroblasts. Here, we showed that TA205 caused an allosteric inhibition of integrin alphaIIb beta3 binding to the talin FERM domain and mapped the TA205 epitope to residues 131-150 in talin F1. Furthermore, binding of a talin rod fragment to talin head was partially inhibited by TA205. These findings suggest that talin F1 may be important in regulation of integrin binding and talin head-rod interaction.
The numerical comparison of flow patterns and propulsive performances for the hydromedusaeSarsia tubulosaandAequorea victoria (2009)

The thrust-generating mechanism of a prolate hydromedusa Sarsia tubulosa and an oblate hydromedusa Aequorea victoria was investigated by solving the incompressible Navier-Stokes equations in the swirl-free cylindrical coordinates. The calculations clearly show the vortex dynamics related to the thrust-generating mechanism, which is very important for understanding the underlying propulsion mechanism. The calculations for the prolate jetting hydromedusa S. tubulosa indicate the formation of a single starting vortex ring for each pulse cycle with a relatively high vortex formation number. However, the calculations for the oblate jet-paddling hydromedusa A. victoria indicate shedding of the opposite-signed vortex rings very close to each other and the formation of large induced velocities along the line of interaction as the vortices move away from the hydromedusa in the wake. In addition to this jet propulsion mechanism, the hydromedusa's bell margin acts like a paddle and the highly flexible bell margin deforms in such a way that the low pressure leeward side of the bell margin has a projected area in the direction of motion. This thrust is particularly important during refilling of the subumbrella cavity where the stopping vortex causes significant pressure drag. The swimming performances based on our numerical simulations, such as swimming velocity, thrust, power requirement and efficiency, were computed and support the idea that jet propulsion is very effective for rapid body movement but is energetically costly and less efficient compared with the jet-paddling propulsion mechanism.
3D MRI characterization of 3D printed tumor tissue models using a plastronic MR-Bioreactor : Preliminary results (2023)

Tissue engineering for regenerative medicine have been developing for a few decades now and the number of applications is increasing to tackle the shortage of organ donors. To date, only few systems can allow both monitoring and 3D characterization of tissue constructs during their growth. In this study, we decided to focus on following the Apparent Diffusion Coefficient (ADC) known to be a marker of cell density and built a MR-Bioreactor to probe the ADC of a growing tissue. In this preliminary work, we were able to follow the cell density of a tumor tissue model using our dedicated MR-bioreactor.
Supplementary Materials and Methods from Resveratrol Promotes Autophagic Cell Death in Chronic Myelogenous Leukemia Cells via JNK-Mediated p62/SQSTM1 Expression and AMPK Activation (2023)

Supplementary Materials and Methods from Resveratrol Promotes Autophagic Cell Death in Chronic Myelogenous Leukemia Cells via JNK-Mediated p62/SQSTM1 Expression and AMPK Activation
Soluble Adenylyl Cyclase Antibody Profile as a Diagnostic Adjunct in the Assessment of Pigmented Lesions (2011)

The sAC expression pattern is complex but seems discriminatory, with distinctive and variable staining patterns according to the nature of the lesion biopsied.
Final report on supplementary comparison EURAMET.EM-S19 (EURAMET project no 688): Bilateral comparison of measurements of current transformers (CTs) between BIM and UME (2011)

This report presents the results of a bilateral comparison on current transformer measurements between BIM (Bulgarian Institute of Metrology) and UME (T?B?TAK Ulusal Metroloji Enstit?s?/NMI of Turkey). The current ratios between 5?A/5?A and 1000?A/5?A were measured at a frequency of 50?Hz with a burden of 5?VA at unity power factor and with different percentage of rated current. The main objective of the comparison was to demonstrate equivalence of metrological practice and to check the correctness of the calibration results. The results of the measurements showed a good agreement between BIM and UME both for the ratio errors and for phase displacements. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by EURAMET, according to the provisions of the CIPM Mutual Recognition Arrangement (MRA).
Phase I Trial of aLactobacillus crispatusVaginal Suppository for Prevention of Recurrent Urinary Tract Infection in Women (2007)

L. crispatus CTV-05 can be given as a vaginal suppository with minimal sideeffects to healthy women with a history of recurrent UTI. Mild inflammation of the urinary tract was noted in some women.
Modulation of Microtubule Dynamics Affects Brucella abortus Intracellular Survival, Pathogen-Containing Vacuole Maturation, and Pro-inflammatory Cytokine Production in Infected Macrophages (2017)

The microtubule (MT) cytoskeleton regulates several cellular processes related to the immune system. For instance, an intricate intracellular transport mediated by MTs is responsible for the proper localization of vesicular receptors of innate immunity and its adaptor proteins. In the present study, we used nocodazole to induce MTs depolymerization and paclitaxel or recombinant (r) TIR (Toll/interleukin-1 receptor) domain containing protein (TcpB) to induce MT stabilization in bone marrow-derived macrophages infected with <i>Brucella abortus</i>. Following treatment of the cells, we evaluated their effects on pathogen intracellular replication and survival, and in pro-inflammatory cytokine production. First, we observed that intracellular trafficking and maturation of <i>Brucella</i>-containing vesicles (BCVs) is affected by partial destabilization or stabilization of the MTs network. A typical marker of early BCVs, LAMP-1, is retained in late BCVs even 24 h after infection in the presence of low doses of nocodazole or paclitaxel and in the presence of different amounts of rTcpB. Second, microscopy and colony forming unit analysis revealed that bacterial load was increased in infected macrophages treated with lower doses of nocodazole or paclitaxel and with rTcpB compared to untreated cells. Third, innate immune responses were also affected by disturbing MT dynamics. MT depolymerization by nocodazole reduced IL-12 production in infected macrophages. Conversely, rTcpB-treated cells augmented IL-12 and IL-1β secretion in infected cells. In summary, these findings demonstrate that modulation of MTs affects several crucial steps of <i>B. abortus</i> pathogenesis, including BCV maturation, intracellular survival and IL-12 secretion in infected macrophages.