gebhart/patrepeval huggingface dataset:
Pyranonaphthoquinone antibiotics. 4. Total synthesis of (+)-griseusin A, an enantiomer of the naturally occurring griseusin A (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPyranonaphthoquinone antibiotics. 4. Total synthesis of (+)-griseusin A, an enantiomer of the naturally occurring griseusin ATadashi Kometani, Yoshio Takeuchi, and Eiichi YoshiiCite this: J. Org. Chem. 1983, 48, 14, 2311–2314Publication Date (Print):July 1, 1983Publication History Published online1 May 2002Published inissue 1 July 1983https://pubs.acs.org/doi/10.1021/jo00162a002https://doi.org/10.1021/jo00162a002research-articleACS PublicationsRequest reuse permissionsArticle Views381Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Coronary Flow Limits Right Ventricular Performance during Positive End-expiratory Pressure (1990)

The effect of positive end-expiratory pressure (PEEP) on right ventricular performance and myocardial blood flow was determined in 16 dogs before and after right coronary artery (RCA) occlusion. Right ventricular ejection fraction (RVEF), end-diastolic volume (EDV) and end-ejection volume were measured by thermodilution. Right ventricular end-ejection pressure-volume relations (RVEEPVR) were determined at baseline and at 20 cm H2O PEEP, both before and after RCA occlusion. In four of the dogs, RVEEPVR were also determined at 10 cm H2O PEEP after RCA occlusion. With intact RCA flow, RVEF declined with PEEP (37 +/- 5 to 19 +/- 6%) with no significant change in EDV (50 +/- 11 to 42 +/- 11 ml) or end-ejection volume (31 +/- 7 to 36 +/- 9 ml). RVEEPVR and right ventricular myocardial blood flow were also unchanged with PEEP. After RCA occlusion, RVEF declined with PEEP (27 +/- 4 to 15 +/- 5%) in association with a significant increase in end-ejection volume (39 +/- 8 to 49 +/- 10 ml), but no change in EDV (53 to 55 ml). In addition, RVEEPVR and myocardial blood flow declined with RCA occlusion, and declined further with 20 cm H2O, but not with 10 cm H2O PEEP, after RCA occlusion. Therefore, in this experimental model, right ventricular performance was adversely affected during PEEP when right coronary blood flow was limited.
Smooth and efficient deoxygenation of secondary alcohols. A general procedure for the conversion of ribonucleosides to 2'-deoxynucleosides (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSmooth and efficient deoxygenation of secondary alcohols. A general procedure for the conversion of ribonucleosides to 2'-deoxynucleosidesMorris J. Robins and John S. WilsonCite this: J. Am. Chem. Soc. 1981, 103, 4, 932–933Publication Date (Print):February 1, 1981Publication History Published online1 May 2002Published inissue 1 February 1981https://doi.org/10.1021/ja00394a033RIGHTS & PERMISSIONSArticle Views1954Altmetric-Citations234LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (291 KB) Get e-Alerts Get e-Alerts
Inhibition of Human Immunodeficiency Virus Forward and Reverse Transcription by PC6, a Natural Product from Cones of Pine Trees (1991)

We have previously shown that PC6, a natural product extracted from cones of Pinus parviflora Sieb et Zucc, can inhibit the replication of human immunodeficiency virus type 1 (HIV-1) in CD4+ T cells and in monocyte/macrophage cell lines. Here, we show by immunoprecipitation of HIV-1 proteins with a specific pooled serum that PC6 inhibited the expression of all HIV-1 proteins in CEM cells. PC6 did not affect the posttranslational processing of the HIV-1 proteins. Northern, Southern, and kinetics analyses revealed that PC6 inhibited HIV-1 reverse and forward transcription in CEM cells. Transient transfection of CEM cells with HIV-1 long terminal repeat (LTR) linked CAT DNA also showed that PC6 inhibited LTR-driven gene expression at the transcriptional level.
NF‐κB activation mediates the response of a subpopulation of basal uroepithelial cells to a cell wall component of Enterococcus faecalis (2000)

Earlier in vitro studies revealed that treatment of basal urothelial cells (UT) with lipoteichoic acid, a cell wall component of Enterococcus faecalis (LT-2), stimulated a subpopulation of quiescent cells with high proliferative potential to divide (Elgavish et al., 1996b, J Cell Physiol 169:42–51). Studies were consistent with the possibility that NO-mediated mechanisms were involved (Elgavish et al., 1996c, J Cell Physiol 169:66–77). We postulated that LT-2 may upregulate expression of iNOS. Promoters of the gene encoding iNOS, as well as genes encoding many cytokines, contain elements homologous to consensus sequences for the binding of the transcription factor NF-κB. Based on this, we postulated that: (1) NF-κB activation is an early event following exposure of basal UT to LT-2 and (2) NF-κB activation mediates basal UT proliferation triggered by LT-2. To test these hypotheses, UT maintained for 3 days under growth-restricting conditions, were treated with or without 25 μg/ml LT-2. Nuclear distribution of NF-κB, that is, activated NF-κB, was detected by immunofluorescence microscopy in a subpopulation of basal UT as early as 5–10 min after the beginning of the treatment. In contrast, LT-2 had no effect on cultures containing more differentiated UT. NF-κB activation preceded production of NO, since treatment with 25 μM hemoglobin, a potent inactivator of NO, did not prevent LT-2-triggered NF-κB activation. Treatment with 10 μM pyrrolidine dithiocarbamate (PDTC) inhibited LT-2-triggered activation of NF-κB and prevented the stimulatory effect of LT-2 on proliferation of basal UT. These findings support the possibility that NF-κB activation mediates basal UT proliferation triggered by LT-2. J. Cell. Physiol. 182:232–238, 2000. © 2000 Wiley-Liss, Inc.
Design and test equipment of digital processors for output analysis from radiation detectors (2011)

The increasing development of configurable electronic systems for digital processing of signals from radiation detectors highlights the convenience of having more and more advanced equipment for support design and test of processing architectures from the hardware and firmware point of view. We propose a configurable design and test equipment that is able to emulate the detection process output on the basis of a description of detector and front-end electronics response that can be analytically calculated or experimentally measured. As case study, we fully developed the emulation of data in applications needing a precise knowledge of the time of occurrence of the events (e.g. coincidence/anti-coincidence, position detection, etc.) in strategic areas of medicine (e.g. PET imaging) such as particle physics (e.g. TDC, beam analysis).
Psychological Responses Matter in Returning to Preinjury Level of Sport After Anterior Cruciate Ligament Reconstruction Surgery (2013)

Psychological responses before surgery and in early recovery were associated with returning to preinjury level of sport at 12 months, suggesting that attention to psychological recovery in addition to physical recovery after ACL injury and reconstruction surgery may be warranted. Clinical screening for maladaptive psychological responses in athletes before and soon after surgery may help clinicians identify athletes at risk of not returning to their preinjury level of sport by 12 months.
A Convenient and Regioselective Oxidative Bromination of Electron‐Rich Aromatic Rings Using Potassium Bromide and Benzyltriphenylphosphonium Peroxymonosulfate under Nearly Neutral Reaction Conditions. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Barrier Properties of Very Thin Ta and TaN Layers Against Copper Diffusion (1998)

Diffusion barrier properties of very thin sputtered Ta and reactively sputtered TaN films used as a barrier layer between Cu and Si substrates were investigated using electrical measurement and materials analysis. The Cu/Ta/p+‐n junction diodes with the Ta barrier of 5, 10, and 25 nm thicknesses were able to sustain a 30 min thermal annealing at temperatures up to 450, 500, and 550°C, respectively, without causing degradation to the device's electrical characteristics. The barrier capability of Ta layer can be effectively improved by incorporation of nitrogen in the Ta film using reactive sputtering technique. For the Cu/TaN/p+‐n junction diodes with the TaN barrier of 5, 10, and 25 nm thicknesses, thermal stability was able to reach 500, 600, and 700°C, respectively. We found that failure of the very thin Ta and TaN barriers was not related to Ta silicidation at the barrier/Si interface. Failure of the barrier layer is presumably due to Cu diffusion through the barrier layer during the process of thermal annealing via local defects, such as grain boundaries and stress‐induced weak points.
Synthesis and rearrangement of (bicyclo[2.2.1]hept-2-ene)bis(triphenylphosphine)platinum(0) complexes (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and rearrangement of (bicyclo[2.2.1]hept-2-ene)bis(triphenylphosphine)platinum(0) complexesPaul G. Gassman and Irene Gennick CesaCite this: Organometallics 1984, 3, 1, 119–128Publication Date (Print):January 1, 1984Publication History Published online1 May 2002Published inissue 1 January 1984https://pubs.acs.org/doi/10.1021/om00079a022https://doi.org/10.1021/om00079a022research-articleACS PublicationsRequest reuse permissionsArticle Views176Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Rituximab Maintenance Versus Observation After Immunochemotherapy (R-CHOP, R-MCP, and R-FCM) in Untreated Follicular Lymphoma Patients: A Randomized Trial of the Ostdeutsche Studiengruppe Hämatologie und Onkologie and the German Low-Grade Lymphoma Study Group (2021)

The German study groups, the German Low-Grade Lymphoma Study Group (GLSG) and Ostdeutsche Studiengruppe Hämatologie und Onkologie (OSHO), initiated in 2007 a double randomized trial to investigate efficacy and safety of rituximab maintenance versus observation in remission after randomly assigned induction treatment in the first-line follicular lymphoma. Previously untreated patients with stage II-IV follicular lymphoma in need of therapy were randomized to receive 6 cycles of R-CHOP, R-MCP, or R-FCM. Responding patients were subsequently randomized to 2 years rituximab maintenance or observation, stratified by type of immunochemotherapy, quality of remission, and Follicular Lymphoma International Prognostic Index (FLIPI). Recruitment was stopped in 2011 after the PRIMA results had been published. Median age of the 206 recruited patients was 66 years (range, 24-86), and (FLIPI) was low in 13%, intermediate in 28%, and high in 60%. High and comparable overall response rates were observed after R-CHOP (88%), R-MCP (89%), and R-FCM (91%). Rituximab maintenance substantially prolonged progression-free survival (PFS) in comparison to observation in remission (hazard ratio 0.39, <i>P</i> = 0.0064). In the rituximab maintenance group, the 3-year PFS was 89% compared with 69% in the observation group. No differences in overall survival were observed for maintenance vs. observation (hazard ratio 1.04, 95% confidence interval 0.32-3.43, <i>P</i> = 0.95). In this randomized trial, 2 years of rituximab maintenance was associated with significantly prolonged PFS in comparison to observation after response to first-line immunochemotherapy in follicular lymphoma. Our data represent an independent confirmation of the PRIMA trial results. (Clinical Trial EudraCT Number: 2005-005473-29, 2006-09-26).
Nonimaging optics and Lommel optics in long-path optical guiding applications (1985)

In a number of long-path optical devices related basically to highly-sensitive absorption spectroscopy and optical delay lines, laser sources and specially designed White-type 1 multireflection cells have been used. The basic disadvantage of such guiding systems is that they are designed by using heavy curved-surface mirrors and based on ray-optics approximation. Hence, such systems are highly sensitive to beam divergence and any kind of mirror surface roughness. A new approach proposed in this paper is based on wave optics, i.e., optics of 2-D limited plane waves or on Lommel 2 optics. Then the guiding system contains only a composition of flat mirror surfaces so that the final device can be light and portable still preserving very long optical paths (up to 100 m, within portable sizes). Moreover, such a system is beam-divergence/mirror-surface-roughness weakly sensitive; hence conventional sources such as LEDs, halogen lamps, etc. can be used, significantly decreasing the cost of the system. Additionally, for concentrating/collimating of the conventional source light beam, Winston’s nonimaging optics 3 is used, highly improving sensitivity and optical S/N of the system.
Faculty Opinions recommendation of Dihydroxyacetone phosphate signals glucose availability to mTORC1. (2020)

The mTOR complex 1 (mTORC1) kinase regulates cell growth by setting the balance between anabolic and catabolic processes. To be active, mTORC1 requires the environmental presence of amino acids and glucose. While a mechanistic understanding of amino acid sensing by mTORC1 is emerging, how glucose activates mTORC1 remains mysterious. Here, we used metabolically engineered human cells lacking the canonical energy sensor AMPK to identify glucose-derived metabolites required to activate mTORC1 independent of energetic stress. We show that mTORC1 senses a metabolite downstream of the aldolase and upstream of the glyceraldehyde 3-phosphate dehydrogenase steps of glycolysis and pinpoint dihydroxyacetone phosphate (DHAP) as the key molecule. In cells expressing a triose kinase, the synthesis of DHAP from dihydroxyacetone is sufficient to activate mTORC1 even in the absence of glucose. DHAP is a precursor for lipid synthesis, a process under the control of mTORC1, which provides a potential rationale for the sensing of DHAP by mTORC1.
Synthesis and Properties of Novel Negative Dielectric Liquid Crystal Compounds with a Tetrahydropyran Ring (2011)

Abstract Novel liquid crystal compounds having a tetrahydropyran ring structure have been developed. These compounds show large optical anisotropy, large absolute negative dielectric anisotropy and higher solubility with other LC compounds compared with conventional high birefringent negative dielectric compounds. The two types of tetrahydropyran derivatives have a chair form cyclohexane ring structure with oxygen in different positions, but they show almost the same dielectric value, and their temperature dependence shows almost the same tendency. In order to clarify this the probabilities of the various conformations were determined. Practical mixtures for the VA-LCD application show improved properties suitable for LCD-TV, also three-dimensional. Keywords: Large optical anisotropynegative dielectric anisotropytetrahydropyran derivativesVA-LCD Notes Extrapolated data from mixtures containing synthesized compounds 15% and nematic host mixture 85%.
Endothelial dysfunction and pathogenesis of diabetic angiopathy (1997)

Endothelial dysfunction plays a key role in the pathogenesis of diabetic angiopathy in man. The biochemical basis of endothelial dysfunction in diabetic man, however, has yet to be fully elucidated.
Giant Electroclinic Effect in Chiral Smectic A Phase of Ferroelectric Liquid Crystals (1987)

A giant electroclinic effect was observed in smectic A (S A ) phases of various ferroelectric liquid crystals with spontaneous polarizations as large as several hundred µC/m 2 . An induced tilt angle increased linearly with an electric field, E , and tended to saturate toward 16° . The induced tilt angle of a few degrees was observable even at a temperature 20° above the S A -S C * transition. It was confirmed using several compounds that the induced tilt angle is proportional to the spontaneous polarization in S C * . The response time is less than 1 µs and, when normalized by the induced tilt angle, linearly depends on E , i.e., τ'/θ 0 ∝ E .
High-pulse energy supercontinuum sources for multi-spectral photoacoustic imaging in the near-infrared wavelength region (Conference Presentation) (2020)

Supercontinuum (SC) lasers are of high interest for applications like multispectral photoacoustic imaging (MSPAI), where the wide optical bandwidth of the SC laser system facilitates functional investigations on top of the structural information of various endogenous agents inside the human body. The current work addresses a promising attempt at devising high pulse energy SC laser source using telecom-range diode laser systems and few meters of standard single-mode fibers for various MSPAI applications in near-infrared (NIR) and extended-NIR wavelength regions.
Methodology of Drought Stress Research: Experimental Setup and Physiological Characterization (2018)

Drought is one of the major stress factors affecting growth and development of plants. In this context, drought-related losses of crop plant productivity impede sustainable agriculture all over the world. In general, plants responses to water deficit by multiple physiological and metabolic adaptations at the molecular, cellular and organism levels. To understand the underlying mechanisms of drought tolerance, adequate stress models and arrays of reliable stress markers are required. Therefore, in this review we comprehensively address currently available models of drought stress, based on culturing plants in soil, hydroponic or agar culture. These experimental setups give access to different aspects of plant response to drought, like decrease of tissue water potential, reduction of stomata conductance and photosynthesis efficiency, accumulation of low-molecular weight solutes (metabolic adjustment) and drought protective proteins. Till now, this pattern of markers was successfully extended to the methods of enzyme chemistry, molecular biology and omics techniques. Thus, conventional tests can be efficiently complemented by determination of phytohormone and reactive oxygen species (ROS) contents, activities of antioxidant enzymes, as well as comprehensive profiling of transcriptome, proteome and metabolome.
Thematic stream: systemic autoimmune disease: OP2. Spleen Tyrosine Kinase Inhibition Prevents Tissue Damage after Ischaemia Reperfusion Injury (2011)

Objectives: Spleen tyrosine kinase (Syk) is responsible for membrane-mediated signaling in various cell types including B lymphocytes, macrophages and T cells. We investigated the ability of a small drug Syk inhibitor, R788, to protect mice against mesenteric ischemia/reperfusion (I/R)-induced local (intestine) and remote lung injury. Methods: Eight-week-old C57Bl/6 mice were used. Syk inhibitor (R788) was given to mice p.o. ad libitum (3 g/kg or 5 g/kg dose, 6 days). We applied an established intestinal IR model We evaluated intestinal and remote organ (lung) injury based on histological score. We also evaluated tissue syk, phospho-syk, C3, platelets, IgG, IgM and GR-1 levels by immunohistochemistry and IFS. Results: Syk inhibitor therapy reduced intestinal injury score (Table 1, Figure 1). Syk staining in intestine and lung were more intensive in IR groups than in Sham. Syk inhibition did not cause any changes any changes in Syk staining in neither the intestine nor the lung tissue. We observed some scanty p-syk staining in IR group. Syk inh therapy attenuated p-syk staining. There was some degree of more staining in IR intestinal and lung samples. Syk inhibition reduced IgM staining. When compared to the sham groups, IR mice had prominent C3 deposition in the intestine. Syk inhibition decreased C3 staining in IR group There was significant deposition of C3 in the lungs of IR mice. Anti-Syk limited C3 deposition in the lung. IR mice had more prominent GR-1 staining within the intestine and lung when compared sham. Syk inhibition prevented IR-induced PMN infiltration. Conclusions: Our data place Syk upstream of events leading to the binding of natural antibodies to the ischemia-conditioned tissues and urge the consideration of the use of Syk inhibitors in the prevention or improvement of tissue injury of organs exposed to ischemia or hypoperfusion.