gebhart/patrepeval huggingface dataset:
Systematic design of an ultrasonic horn profile for high displacement amplification (2012)

A new analytical-numerical technique is proposed to design a high displacement amplification ultrasonic horn. The profile of the horn is a NURBS curve whose parameters can be optimized to attain a high displacement amplification factor. Compared to the traditional finite element-based design approach of ultrasonic horns, which is case dependent, our approach formulates and solves the optimal horn profile problem in nondimensional space. Therefore, both the working frequency and the length of the system can be readily adjusted. Depending on the number of control points and their associated weights, the NURBS profile can be simplified to a Bezier, a rational Bezier or a B-spline curve. The optimum profile for each type of curve is then sought and the corresponding amplification factor, natural frequency and maximum strain are verified using finite element analysis. Considering a horn with a cross-sectional ratio of 16, amplification factors of 11.55, 12.12, 13.55 and 15.97 are obtained for the optimum profiles of Bezier, rational Bezier, B-spline and NURBS curves, respectively.
Infrapopliteal arterial bypass for limb salvage: increased patency and utilization of the saphenous vein used "in situ". (1981)

A prospective study of "in situ" saphenous vein has been made to determine its patency and utilization when used for arterial bypass distal to the popliteal artery. The valvular obstructions to arterial flow were removed by the method of valve incision developed by the authors. Of 316 consecutive "in situ" bypass procedures, 133 attempts were made to complete the procedure to the infrapopliteal level for limb salvage. One hundred and twenty-four of these were completed, to 43 peroneal, 40 posterior tibial, 25 anterior tibial, and 16 tibioperoneal arteries. At the level of its distal transection, the saphenous veins had diameters of 3.5 to 2.5 mm in 58 cases (45%). Only 7% of these procedures could not be completed without resorting to the use of excised vein segments. There were seven occlusions within 30 days (94% immediate patency rate). Cumulative patency rates by life-table analysis at 1, 2, and 3 years were 87%, 82%, and 72%, respectively. Neither the vein diameter nor the location of the distal anastomosis had any effect on these patency rates. In spite of the immediate failure rate of 15% to 30%, reversed autogenous saphenous vein is the present material of choice for infrapopliteal bypass. However, when the generally accepted minimum diameter of 4 mm is applied, at least 25% of these veins may not meet this criterion. These data show that the "in situ" method allows for both increased bypass patency and utilization of saphenous vein by permitting the consistent use of increased bypass patency and utilization of saphenous vein by permitting the consistent use of veins of 3.5 mm diameter or less. The summation of these improved utilization and patency rates has resulted in a greater number of functioning bypasses when compared to the present experience with reversed saphenous vein and/or nonautogenous substitutes in current use.
DNA Sequence-recognizing Properties of Minor Groove Alkylating Agents (2011)

The linkage of an heterocycle, like N-methylimidazole, to minor DNA groove binders containing two or three pyrroles lead to a new class of oligopeptides with reduced antitumor activity both in vitro and in vivo if compared to tallimustine (CAS 115308-98-0) and its tetrapyrrole homologue 9. In the present paper is reported the correlation between the cytoxicity of tallimustine and its derivatives 9-11 with their ability to inhibit polymerase chain reaction (PCR) amplification of oestrogen receptor and Ha-ras gene sequences, containing A + T rich and G + C rich regions, respectively. Tallimustine and its tetrapyrrole homologue 9 were found to have higher sequence selectivity for the human oestrogen receptor (ER) gene with respect to the relative imidazole-containing analogues.
Glycerol Production in a Triose Phosphate Isomerase Deficient Mutant of Saccharomyces cerevisiae (1996)

Interesting challenges from metabolically engineered Saccharomyces cerevisiae cells arise from the opportunity to obtain yeast strains useful for the production of chemicals. In this paper, we show that engineered yeast cells deficient in the triose phosphate isomerase activity are able to produce glycerol without the use of steering agents. High yields of conversion of glucose into glycerol (80-90% of the theoretical yield) and productivity (1.5 g L-1 h-1) have been obtained by a bioconversion process carried out in a poor and clean medium. We obtained indications that the growth phase at which the biomass was collected affect the process. The best results were obtained using cells collected at the end of exponential phase of growth. In perspective, the strategies and the information about the physiology of the cells described here could be useful for the developing of new biotechnological processes for glycerol production, outflanking the problems related to the use of high level of steering agents.
Infiltration of the Leptomeninges by Systemic Cancer (1974)

Leptomeningeal invasion by systemic cancer was diagnosed clinically or pathologically in 50 patients over four years. All had neurological symptoms referable to tumor seeding the meninges. Clinical diagnosis was suggested by the simultaneous occurrence of symptoms or signs in more than one area of the neuraxis. Neurological signs were much more prominent than symptoms. Clinical diagnosis was confirmed by the presence of malignant cells in the cerebrospinal fluid (CSF), multiple examinations of CSF sometimes being necessary. The disease was usually inexorably progressive, but in some instances responded to radiation and intrathecal chemotherapy. At autopsy there were leptomeningeal thickening, occasionally tumor nodules along the cauda equina and, in some patients, hydrocephalus. Sometimes, despite prominent clinical signs, there were no gross pathologic abnormalities. Microscopic changes were multifocal rather than diffuse, making extensive sampling of leptomeninges necessary to establish the pathologic diagnosis.
Reciprocal expression of IL‐25 and IL‐17A is important for allergic airways hyperreactivity (2011)

IL-13 is known to be an important inducer of lung inflammation, causing goblet cell hyperplasia and promoting airways hyperreactivity. Our data now demonstrate that IL-13 also plays an important role in the genesis of lung inflammation downstream of IL-25 by suppressing a protective IL-17A response. These findings also highlight the important reciprocal interplay of the IL-17 family members, IL-25 and IL-17A, in regulating allergic lung responses and suggest that the balance of IL-17A, together with IL-25, will be an important consideration in the treatment of allergic asthma.
Assessment of Physician Self-reported Knowledge and Use of Maryland’s Extreme Risk Protection Order Law (2019)

Awareness of ERPOs among physicians in the sample was low. Physicians are treating patients who would qualify for an ERPO, and respondents in the sample indicated a willingness to use ERPOs. Training, providing access to legal counsel, designating a clinician to process petitions, and allowing clinicians to participate remotely in court hearings were strategies respondents identified to address barriers to ERPO use. These survey findings identify concrete solutions for addressing barriers to physician use of ERPOs.
More on identifying inherited deficiency of porphobilinogen synthase. (1985)

Journal Article More on identifying inherited deficiency of porphobilinogen synthase. Get access R F Labbé, R F Labbé Search for other works by this author on: Oxford Academic Google Scholar T J Bird T J Bird Search for other works by this author on: Oxford Academic Google Scholar Clinical Chemistry, Volume 31, Issue 1, 1 January 1985, Page 162, https://doi.org/10.1093/clinchem/31.1.162 Published: 01 January 1985
A culture platform to study quiescent hematopoietic stem cells following genome editing (2022)

Other than genetically engineered mice, few reliable platforms are available for the study of hematopoietic stem cell (HSC) quiescence. Here we present a platform to analyze HSC cell cycle quiescence by combining culture conditions that maintain quiescence with a CRISPR-Cas9 genome editing system optimized for HSCs. We demonstrate that preculture of HSCs enhances editing efficiency by facilitating nuclear transport of ribonucleoprotein complexes. For post-editing culture, mouse and human HSCs edited based on non-homologous end joining and cultured under low-cytokine, low-oxygen, and high-albumin conditions retain their phenotypes and quiescence better than those cultured under the proliferative conditions. Using this approach, HSCs regain quiescence even after editing by homology-directed repair. Our results show that low-cytokine culture conditions for gene-edited HSCs are a useful approach for investigating HSC quiescence <i>ex vivo</i>.
Cover Image, Volume 38, Issue 1 (2017)

On the cover: The cover image, by Ana Marta de Matos et al., is based on the Review Article Bridging Type 2 Diabetes and Alzheimer's Disease: Assembling the Puzzle Pieces in the Quest for the Molecules With Therapeutic and Preventive Potential, https://doi.org/10.1002/med.21440.
Deficient Glutathione in the Pathophysiology of Mycotoxin-Related Illness (2014)

Evidence for the role of oxidative stress in the pathophysiology of mycotoxin-related illness is increasing. The glutathione antioxidant and detoxification systems play a major role in the antioxidant function of cells. Exposure to mycotoxins in humans requires the production of glutathione on an "as needed" basis. Research suggests that mycotoxins can decrease the formation of glutathione due to decreased gene expression of the enzymes needed to form glutathione. Mycotoxin-related compromise of glutathione production can result in an excess of oxidative stress that leads to tissue damage and systemic illness. The review discusses the mechanisms by which mycotoxin-related deficiency of glutathione may lead to both acute and chronic illnesses.
AFM Probing of Polymer/Nanofiller Interfacial Adhesion and Its Correlation with Bulk Mechanical Properties in a Poly(ethylene terephthalate) Nanocomposite (2014)

The interfacial adhesion between polymer and nanofiller plays an important role in affecting the properties of nanocomposites. The detailed relationship between interfacial adhesion and bulk properties, however, is unclear. In this work, we developed an atomic force microscopy (AFM)-based abrasive scanning methodology, as applied to model laminate systems, to probe the strength of interfacial adhesion relevant to poly(ethylene terephthalate) (PET)/graphene or clay nanocomposites. Graphite and mica substrates covered with ∼2 nm thick PET films were abrasively sheared by an AFM tip as a model measurement of interfacial strength between matrix PET and dispersed graphene and clay, respectively. During several abrasive raster-scan cycles, PET was shear-displaced from the scanned region. At temperatures below the PET glass transition, PET on graphite exhibited abrupt delamination (i.e., full adhesive failure), whereas PET on mica did not; rather, it exhibited a degree of cohesive failure within the shear-displaced layer. Moreover, 100-fold higher force scanning procedures were required to abrade through an ultimate "precursor" layer of PET only ∼0.2-0.5 nm thick, which must be largely disentangled from the matrix polymer. Thus, the adhesive interface of relevance to the strength of clay-filler nanocomposites is between matrix polymer and strongly bound polymer. At 90 °C, above the bulk PET glass transition temperature, the PET film exhibited cohesive failure on both graphite and mica. Our results suggest that there is little difference in the strength of the relevant interfacial adhesion in the two nanocomposites within the rubbery dynamic regime. Further, the bulk mechanical properties of melt mixed PET/graphene and PET/clay nanocomposites were evaluated by dynamic mechanical analysis. The glassy dynamic storage modulus of the PET/clay nanocomposite was higher than that of PET/graphene, correlating with the differences in interfacial adhesion probed by AFM.
Hydrogenation of Ethyl Acetate to Ethanol over Ni-Based Catalysts Obtained from Ni/Al Hydrotalcite-Like Compounds (2010)

A series of Ni-based catalysts were prepared using hydrogen reduction of Ni/Al hydrotalcite-like compounds (Ni/Al HTlcs) synthesized by coprecipitation. The physico-chemical properties of Ni/Al hydrotalcite-like compounds and the corresponding Ni-based catalysts were characterized using inductively coupled plasma (ICP), BET surface areas, X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM) techniques. The results indicated that Ni/Al HTlcs with layered structures could be successfully prepared by the coprecipitation method, and the characteristic HTlcs reflections were also observed in the XRD analysis. The NiO and Ni0 phases were identified in all Ni-based catalysts, which displayed randomly interconnected pores and no layer structures. In addition, the studies also found the Ni/Al HTlcs and Ni-based catalysts had high specific surface areas, low pore volumes and low pore diameters. The catalytic hydrogenation of ethyl acetate to ethanol with Ni-based catalysts was also investigated. Among the studied catalysts, RE1NASH-110-3 showed the highest selectivity and yield of ethyl acetate to ethanol, which were 68.2% and 61.7%, respectively. At the same time, a major by-product, butyl acetate, was formed due to an ester-exchange reaction. A proposed hydrogenation pathway for ethyl acetate over Ni-based catalysts was suggested.
<title>Formation of elongated laser sparks in gas puff targets by nanosecond laser pulses</title> (1997)

The formation of an elongated laser spark in a high density gas puff target has been studied experimentally using 10 J 1.5 ns Nd:glass laser pulses. The laser sparks were created by focusing the laser beam on the gas puff targets with a spherical lens or an axicon. The spark was characterized using an imaging system with CCD camera and a grazing incidence grating x-ray spectrometer. Propagation of the second laser pulse of 1.5 ns time duration along the spark plasma was also studied.
Prolonged Transesophageal Echocardiography Use in the ICU (2011)

Transesophageal echocardiography (TEE) has gained increasing popularity in the operating room and intensive care settings. The use of TEE can often times diagnose pathology that is missed by transthoracic echocardiography (TTE); in addition, it can be used as a guide to continuously monitor a patient’s hemodynamics, along with observing the direct cardiac effects of fluid and vasopressor therapy. We present a case of acute fulminant hepatic failure in the ICU, where TEE allowed a rapid diagnosis. We performed prolonged TEE monitoring (72 hours) of the patient to monitor the patient’s response to therapeutic interventions. We also discuss the diagnostic and therapeutic implications of prolonged TEE placement in the ICU. In addition, particular strategies to optimize the benefit and minimize the risk of this exciting, yet underutilized, technology are discussed.
Advances in fiber interferometer hydrophones (1979)

Progress on the development of fiber interferometer hydrophones is presented. Baseline low-frequency noise has been systematically reduced over the past year. A dramatic improvement in minimum detectable pressure of fiber hydrophones at frequencies between 200 Hz and 1 kHz was recently achieved by the incorporation of state of the art optical components. The potential for increased performance of fiber interferometers is discussed.
Synaptic interference channel (2013)

Synaptic channels automatically adapt their weights to compensate for the variations resulted from the input and output characteristics, i.e., spike frequency, time correlation among inputs, time difference between presynaptic and postsynaptic action potentials. Modification of the synaptic conductances, i.e., channel weights, is the main mechanism that enables learning in neurons. In this paper, we approach this learning mechanism from a different perspective. First, we analyze the single-input single-output (SISO) and multi-input single-output (MISO) synaptic interference channels, and achievable communication rates. Furthermore, we provide the natural adaptive weight update algorithm for neurons based on experimental findings. Our results demonstrate that neurons are capable of mitigating the interference, and achieve rates close to the capacity.
Anticardiolipin in Porphyromonas gingivalis Antisera Causes Fetal Loss in Mice (2013)

β2-glycoprotein I (β2GPI)-dependent anticardiolipin autoantibodies (aCl) are associated with thrombosis and fetal loss. Some microbial pathogens can induce pathogenic antibodies cross-reactive with β2GPI. Sera from a significant percentage of periodontitis patients contain aCl, and some periodontal pathogens contain antigens with peptide sequences having homology to β2GPI. We hypothesized that antibodies raised against P. gingivalis (aPg) contain pathogenic aCl that induce fetal resorption. We immunized mice with β2GPI, P. gingivalis W83, or an arg-gingipain-defective mutant of P. gingivalis (HF18). IgG fractions of aPg were immunoabsorbed to remove aCl-like antibodies (abs-aPg). IgG fractions were administered intravenously into tail veins of mated BALB/c females at day 0 of pregnancy. At day 15, the proportions of fetal resorptions were evaluated. The prevalence of fetal loss was significantly greater in the aPg group than in the control IgG group (21.2% vs. 5.3%, p = .001), and greater in the aPg group than in the abs-aPg group (21.2% vs. 12%, p < .05). There were no fetal resorptions observed in the aPgHF18 group (p = .0005 compared with aPg, p = .17 compared with control). aPg antibody contains activity consistent with pathogenic aCl, and the antigen inducing the antibodies that cause increased fetal loss may be on the arg-gingipain protease of P. gingivalis.
NAUTILUS (Safety and tolerability of Niaspan®): a subgroup analysis in patients with diabetes (2006)

The multiceNtre, open, uncontrolled sAfety and tolerability stUdy of a modified-release nicoTinic acId formuLation in sUbjects with dySlipidaemia and low HDL-cholesterol (NAUTILUS) trial was designed to evaluate the safety and tolerability of prolonged-release nicotinic acid (Niaspan®) in patients treated for dyslipidaemia in a usual care setting in Germany. The dyslipidaemia was inadequately controlled by diet, including low high-density lipoprotein cholesterol (HDL-C) (&lt; 1.0 mmol/L [&lt; 40 mg/dL] in men and &lt; 1.2 mmol/L [&lt;46 mg/dL] in women). This analysis focuses on the tolerability and safety of Niaspan® in patients with diabetes. Diabetic and non-diabetic subjects reported similar incidences of all-cause adverse events (AE; 59.9% vs. 60.8%, respectively), serious AE (SAE; 4.0% vs. 3.4%, respectively) and withdrawals for AE (17.6% vs. 16.4%). Flushing was the most common side effect, as expected (42% of patients in each group), but &lt; 10% withdrew for flushing. There was no indication of hepatotoxicity or serious muscle toxicity in diabetic or non-diabetic subjects. Changes in glycaemic parameters were small (mean changes in diabetic subjects of +0.2% HbA 1C and +0.4 mmol/L [+8 mg/dL] for fasting plasma glucose), despite marked reductions in the intensity of antidiabetic therapy in about one third of patients. Niaspan® was equally effective in diabetic or non-diabetic subjects in increasing HDL-C (+24% in each group) and decreasing triglycerides (-12% and -13%, respectively). Niaspan® was well tolerated in patients with type 2 diabetes and the results of NAUTILUS support its use for correction of low HDL-C in this population.
Effectiveness of Bone Metastases Treatment by Sm–153 Oxabifore in Combination with Monoclonal Antibody Denosumab (Xgeva): First Experience (2013)

Breast and prostate cancer have a propensity to metastasize to bones and cause osteolysis and abnormal new bone formation. Metastases locally disrupt normal bone remodeling. Although metastases from prostate cancer have been classified as osteoblastic based on the radiographic appearance of the lesion, data gleaned from a rapid autopsy program indicate that the same prostate cancer patient may have evidence of both osteolytic and osteoblastic disease as shown by histologic examinations. Thus, bone metastases are heterogeneous, requiring combined treatment targeting on both osteolytic and osteoblastic lesions. While Samarium-153 (Sm-153) oxabifore treatment is widely used for the relief of pain in patients with osteoblastic metastatic bone lesions, Xgeva (Denosumab) is indicated for the prevention of skeletal-related events in patients with bone metastases from solid tumors. It is a fully human monoclonal antibody that has been designed to target receptor activator of nuclear factor-kB ligand (RANKL), a protein that acts as the primary signal to promote bone removal. In many bone loss conditions, RANKL overwhelms the body's natural defense against bone destruction. The main objectives of the current pilot study were to estimate the effectiveness of bone metastases treatment by a combination of Sm-153 oxabifore and Xgeva (Denosumab). Five patients (four female and one male, aged 35-64, mean age 50.8) with multiple skeletal metastases from prostatic carcinoma (1) and breast carcinoma (4) were studied. Their mean objective pain score according to visual analog scoring system on a 1-10 scoring system was 7.8 ± 0.5 (range 6-9). Sm-153 oxabifore was administered at the standard bone palliation dose of 37 MBq/kg body weight. Xgeva (Denosumab) was administered at a dosage of 120 mg every 4 weeks, with the monitoring of calcium level and administration of calcium, magnesium, and vitamin D. Whole body (WB) bone scan was performed before and 3 months after treatment in all patients. After Sm-153 oxabifore administration, pain relief occurred within 4.4 ± 1.25 days (range 2-9 days) and the objective pain score decreased to 0.2 ± 0.2 (range 0-1). There was statistically significant difference found, according to the pain score system, before and after treatment (P < 0.0001). WB bone scan showed that in one patient, there was significant reduction in the number and intensity of bone metastases, and in four patients, there was no evidence of bone metastases found. Based on our first experience, combined treatment of bone metastases with Sm-153 oxabifore and Denosumab is effective and safe.
Convenient synthesis of 9-methylbenzo[a]pyrene (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConvenient synthesis of 9-methylbenzo[a]pyreneJohn W. Lyga and John A. Secrist IIICite this: J. Org. Chem. 1979, 44, 16, 2941–2943Publication Date (Print):August 1, 1979Publication History Published online1 May 2002Published inissue 1 August 1979https://pubs.acs.org/doi/10.1021/jo01330a026https://doi.org/10.1021/jo01330a026research-articleACS PublicationsRequest reuse permissionsArticle Views496Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts