gebhart/patrepeval huggingface dataset:
Non-competitive anti-oestrogenic activity of progesterone antagonists in primate models (1994)

We have summarized some of the studies containing basic biological data suggesting potential therapeutic utility of the anti-proliferative activity of antiprogestins on uterine tissues. The non-competitive anti-oestrogenic effects of RU486 were examined using oestradiol-treated ovariectomized monkeys given RU486, progesterone or both. The oestradiol-induced luteinizing hormone surge of control animals was abrogated by progesterone and/or RU486. Secretory transformation by progesterone was inhibited by RU486 co-administration. RU486 alone (1 mg/kg) induced endometrial secretory transformation, but higher doses (5 mg/kg) induced inhibited proliferation and secretory activity. Thus, in the presence of progesterone, RU486 is antagonistic but, in its absence, RU486 exhibits endometrial progestational effects at low doses and an anti-proliferative (anti-oestrogenic) effect at higher doses. These data encourage continued evaluation of RU486 as a potential contraceptive agent acting at the pituitary and/or endometrial level. Our study also demonstrates that after physiological oestradiol replacement therapy, oestradiol receptor concentrations rise dramatically following antiprogestin treatment; this effect was dose-dependent.
GaN/ZnO nanorod light emitting diodes with different emission spectra (2009)

Light emitting diodes (LEDs) consisting of p-GaN epitaxial films and n-ZnO nanorods have been fabricated and characterized. The rectifying behavior and emission spectra were strongly dependent on the electronic properties of both GaN film and ZnO nanorods. Light emission under both forward and reverse bias was obtained in all cases, and emission spectra could be changed by annealing the ZnO nanorods. The emission spectra could be further tuned by using a GaN LED epiwafer as a substrate. Both forward and backward diode behavior has been observed and the emission spectra were significantly affected by both the properties of the GaN substrate and the annealing conditions for the ZnO nanorods.
Neurologic manifestations of endocrine disease (2002)

Neurological signs and symptoms occur in virtually every known endocrine disturbance. This chapter focuses primarily on the neurological manifestations of diseases of the thyroid and the adrenal glands. The neurological complications of parathyroid disease largely reflect disordered calcium metabolism and are discussed in Chapter 124. The numerous neurological complications of diabetes mellitus, hypoglycemia, and pancreatic disorders are also dealt with elsewhere. Neurological manifestations of the hypothalamus and pituitary disease are reviewed in Chapter 57. The endocrine disturbances associated with anorexia nervosa are considered in Chapter 54.
Results of a Randomized Clinical Trial of Speech After Early Neurostimulation in Parkinson's Disease (2022)

At this early stage of the patients' disease, STN-DBS did not result in a consistent deterioration in blinded speech intelligibility assessment and patient-reported communication, as observed in studies of advanced Parkinson's Disease. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Exploring DRAM organizations for energy-efficient and resilient exascale memories (2013)

The power target for exascale supercomputing is 20MW, with about 30% budgeted for the memory subsystem. Commodity DRAMs will not satisfy this requirement. Additionally, the large number of memory chips (>10M) required will result in crippling failure rates. Although specialized DRAM memories have been reorganized to reduce power through 3D-stacking or row buffer resizing, their implications on fault tolerance have not been considered. We show that addressing reliability and energy is a co-optimization problem involving tradeoffs between error correction cost, access energy and refresh power---reducing the physical page size to decrease access energy increases the energy/area overhead of error resilience. Additionally, power can be reduced by optimizing bitline lengths. The proposed 3D-stacked memory uses a page size of 4kb and consumes 5.1pJ/bit based on simulations with NEK5000 benchmarks. Scaling to 100PB, the memory consumes 4.7MW at 100PB/s which, while well within the total power budget (20MW), is also error-resilient.
Dynamics of transient speciesviaanion photodetachment (2017)

The dynamics of chemical reactions are often governed by transient species, including the transition state for activated bimolecular reactions. Such transient species are difficult to study experimentally, but it has proven valuable to prepare and probe transition-state dynamics by the photodetachment of anions with an equilibrium geometry similar to the neutral transition state. In this review, recent experimental advances in photoelectron and photoelectron-photofragment coincidence spectroscopy are discussed, as well as the latest progress in the calculation of multidimensional potential energy surfaces and quantum dynamics calculations that have enabled an extension of studies of transition-state dynamics to increasingly multidimensional polyatomic systems. Examples of important dynamical effects such as mode specificity, tunneling, resonance and product energy disposal in reaction dynamics are discussed.
Catalysis of the cis → trans Isomerization of 2-Hydroxy-5-methylazobenzene (1965)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCatalysis of the cis → trans Isomerization of 2-Hydroxy-5-methylazobenzeneGunnar Wettermark, Margaret E. Langmuir, and Daniel G. AndersonCite this: J. Am. Chem. Soc. 1965, 87, 3, 476–481Publication Date (Print):February 1, 1965Publication History Published online1 May 2002Published inissue 1 February 1965https://pubs.acs.org/doi/10.1021/ja01081a014https://doi.org/10.1021/ja01081a014research-articleACS PublicationsRequest reuse permissionsArticle Views338Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Trypanosoma cruzitrans-sialidase: A potent and specific survival factor for human Schwann cells by means of phosphatidylinositol 3-kinase/Akt signaling (2001)

Patients infected with Trypanosoma cruzi may remain asymptomatic for decades and show signs of neuroregeneration in the peripheral nervous system (PNS). In the absence of such neuroregeneration, patients may die in part by extensive neuronal destruction in the gastrointestinal tract. Thus, T. cruzi may, despite their invasion of the PNS, directly prevent cell death to keep nerve destruction in check. Indeed, T. cruzi invasion of Schwann cells, their prime target in PNS, suppressed host-cell apoptosis caused by growth-factor deprivation. The trans-sialidase (TS) of T. cruzi and the Cys-rich domain of TS reproduced the antiapoptotic activity of the parasites at doses (> or =3.0 nM) comparable or lower than those of bona fide mammalian growth factors. This effect was blocked by LY294002, an inhibitor of phosphatidylinositol 3-kinase (PI3K). TS also activated Akt, a downstream effector of PI3K. Ectopic expression of TS in an unrelated parasite, Leishmania major, turned those parasites into activators of Akt in Schwann cells. In contrast, the Cys-rich domain of TS did not block apoptosis in Schwann cells overexpressing dominant-negative Akt or constitutively active PTEN, a negative regulator of PI3K/Akt signaling. The results demonstrate that T. cruzi, through its TS, triggers the survival of host Schwann cells via the PI3K/Akt pathway, suggesting a role for PI3K/Akt in the pathogenesis of Chagas' disease.
Phosphorylation of Serine 106 in Asef2 Regulates Cell Migration and Adhesion Turnover (2014)

Asef2, a 652-amino acid protein, is a guanine nucleotide exchange factor (GEF) that regulates cell migration and other processes via activation of Rho family GTPases, including Rac. Binding of the tumor suppressor adenomatous polyposis coli (APC) to Asef2 is known to induce its GEF activity; however, little is currently known about other modes of Asef2 regulation. Here, we investigated the role of phosphorylation in regulating Asef2 activity and function. Using high-resolution mass spectrometry (MS) and tandem mass spectrometry (MS/MS), we obtained complete coverage of all phosphorylatable residues and identified six phosphorylation sites. One of these, serine 106 (S106), was particularly intriguing as a potential regulator of Asef2 activity because of its location within the APC-binding domain. Interestingly, mutation of this serine to alanine (S106A), a non-phosphorylatable analogue, greatly diminished the ability of Asef2 to activate Rac, while a phosphomimetic mutation (serine to aspartic acid, S106D) enhanced Rac activation. Furthermore, expression of these mutants in HT1080 cells demonstrated that phosphorylation of S106 is critical for Asef2-promoted migration and for cell-matrix adhesion assembly and disassembly (adhesion turnover), which is a process that facilitates efficient migration. Collectively, our results show that phosphorylation of S106 modulates Asef2 GEF activity and Asef2-mediated cell migration and adhesion turnover.
Injuries associated with electric-powered bikes and scooters: analysis of US consumer product data (2019)

E-bike and powered scooter use and injury patterns differ from more traditional pedal operated bicycles. Efforts to address injury prevention and control are warranted, and further studies examining demographics and hospital resource utilisation are necessary.
Managing business processes as an information resource (1994)

The relevance of business processes as a major asset of an enterprise is more and more accepted: Business processes prescribe the way in which the resources of an enterprise are used, i.e., they describe how an enterprise will achieve its business goals. Organizations typically prescribe how business processes have to be performed, and they seek information technology that supports these processes. We describe a system that supports the two fundamental aspects of business process management, namely the modeling of processes and their execution. The meta-model of our system deals with models of business processes as weighted, colored, directed graphs of activities; execution is performed by navigation through the graphs according to a well-defined set of rules. The architecture consists of a distributed system with a client/server structure, and stores its data in an object-oriented database system.
Electrical Resistance of Single-Crystal Single-Domain Chromium from 77 to 325 °K (1971)

Detailed measurements of the electrical resistance of a pure chromium single crystal, $\frac{{R}_{300}}{{R}_{4.2}}=350$, have been made over the temperature range 77-325 \ifmmode^\circ\else\textdegree\fi{} K for both the single-domain $\stackrel{\ensuremath{\rightarrow}}{\mathrm{J}}\ensuremath{\parallel}\stackrel{\ensuremath{\rightarrow}}{\mathrm{Q}}$ and multidomain cases. The resistance for $\stackrel{\ensuremath{\rightarrow}}{\mathrm{J}}\ensuremath{\parallel}\stackrel{\ensuremath{\rightarrow}}{\mathrm{Q}}$ was about 4% greater than for the multidomain case from 100 to 250 \ifmmode^\circ\else\textdegree\fi{}K. No discontinuities in resistance or changes in the derivative of the resistance with respect to temperature were observed near the spin-flip temperature, nor were any discontinuities or precursor effects observed at the N\'eel temperature. The excess resistance due to the antiferromagnetic condensation below the N\'eel temperature obeys a power law in the reduced temperature difference, $\frac{({T}_{N}\ensuremath{-}T)}{{T}_{N}}$ for more than two decades with an exponent of 0.57 \ifmmode\pm\else\textpm\fi{} 0.03 for $\stackrel{\ensuremath{\rightarrow}}{\mathrm{J}}\ensuremath{\parallel}\stackrel{\ensuremath{\rightarrow}}{\mathrm{Q}}$ and 0.58 \ifmmode\pm\else\textpm\fi{} 0.02 for the multidomain case.
Proteus: An ASIC Flow for GHz Asynchronous Designs (2011)

Editors' note:The high-performance benefits of asynchronous design have hitherto been obtained only using full-custom design. This article presents an industrial-strength asynchronous ASIC CAD flow that enables the automatic synthesis and physical design of high-level specifications into GHz silicon, greatly reducing design time and enabling far wider use of asynchronous technology.—Montek Singh (UNC Chapel Hill) and Luciano Lavagno (Politecnico di Torino)
Gene Transfer of the Catabolic Inhibitor TIMP-1 Increases Measured Proteoglycans in Cells from Degenerated Human Intervertebral Discs (2003)

Successful delivery of the anticatabolic gene, TIMP-1, results in increased measured proteoglycan in cultured degenerated disc cells. This finding supports catabolic inhibition as a promising avenue of research for the treatment of degenerative disc disease via gene therapy.
Mental, Physical and Social Components in Leisure Activities Equally Contribute to Decrease Dementia Risk (2005)

These findings suggest that a broad spectrum of activities containing more than one of the components seems to be more beneficial than to be engaged in only one type of activity.
44.4L: FLC Polymer and Plastic Substrates for Use in a Large‐Area Optical Shutter for 3‐D TV (1998)

Abstract We have developed large area liquid crystal displays combining polymerized ferroelectric liquid crystal and plastic substrate. As an interesting application, 32‐inch(aspect ratio 16:9) film LCD was introduced as an optical shutter for 3D television. The shutter is attached directly to the face plate of 32‐inch conventional TV monitor with the polarizer in the back of the LCD, and we can observe 3D image easily only by wearing glasses with two polarizers in parallel and perpendicular arrangement to the polarizer in the back of the LCD.
Using agent technology to streamline negotiations in apparel supply chains (2011)

Negotiation is a critical part of communication system in a supply chain [1]. Indecisions due to lengthy negotiation processes may lead to poor supply chain performance.
Transseptal access: A review of contemporary tools (2022)

Transseptal left atrial catheterization is routinely used for many common catheter-based interventions. Tools for transseptal catheterization have advanced over the recent years. Such tools include imaging advances with intracardiac echocardiology as well as an array of needles, wires, and dilators to achieve transseptal access with greater ease and safety. This study will discuss the contemporary tools for transseptal catheterization and guidance for difficult cases.
Anomalous Preaortic Interazygous Vein (1983)

Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 South Kingshighway, St. Louis, MO 63110.
Flüssig‐kristalline Zustände in Cellulose‐ und Cellulosederivatlösungen (1984)

Abstract In einer Literaturübersicht wird der Kenntnisstand zu Fragen der Charakterisierung mesomorpher Strukturen in Cellulose‐ und Cellulosederivatlösungen zusammengestellt. Eigene experimentelle Untersuchungen zur Charakterisierung des flüssig‐kristallinen Zustandes von Cellulosederivatlösungen sollen die Eignung vorhandener Charakterisierungsmethoden demonstrieren und Erfahrungen für den Umgang mit diesen Stoffsystemen vermitteln.
Abstract A221: Novel PARP6 inhibitors demonstrate in vivo efficacy in xenograft models. (2013)

Abstract The poly (ADP-ribose) polymerase (PARP) family of enzymes are functionally implicated in DNA repair, transcriptional regulation, glucose metabolism, mitosis, and other cellular mechanisms. To date, the focus has been on defining the role of PARPs 1-3 in DNA damage repair. Currently, PARP1-3 inhibitors are in clinical trials for BRCA1/2 mutant ovarian and breast cancers. The roles of other PARP family members are starting to emerge. Using a cell-based assay measuring multi-polar spindle induction, PARP6 was identified as novel target with therapeutic potential. AZ482 and AZ108 were developed as potent PARP6 inhibitors. These compounds exhibited a unique and selective growth inhibition profile when screened in large panels of tumor cells and suitable pharmacokinetics in vivo. In sensitive hematological and solid tumor models, these compounds had low nanomolar potency in vitro and anti-tumor efficacy in vivo. Mechanistic studies suggest PARP6 inhibitors disrupt spindle pole clustering resulting in mitotic catastrophe and may show selectivity toward tumor cell lines with supernumary centrosomes. Citation Information: Mol Cancer Ther 2013;12(11 Suppl):A221. Citation Format: Michele F. Mayo, Shaun Grosskurth, Xin Wang, Philip Petteruti, Prasad Nadella, Corinne Reimer, Keith Mikule. Novel PARP6 inhibitors demonstrate in vivo efficacy in xenograft models. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2013 Oct 19-23; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2013;12(11 Suppl):Abstract nr A221.
Natural and experimental oral infection of nonhuman primates by bovine spongiform encephalopathy agents (1999)

Experimental lemurs either were infected orally with the agent of bovine spongiform encephalopathy (BSE) or were maintained as uninfected control animals. Immunohistochemical examination for proteinase-resistant protein (prion protein or PrP) was performed on tissues from two infected but still asymptomatic lemurs, killed 5 months after infection, and from three uninfected control lemurs. Control tissues showed no staining, whereas PrP was detected in the infected animals in tonsil, gastrointestinal tract and associated lymphatic tissues, and spleen. In addition, PrP was detected in ventral and dorsal roots of the cervical spinal cord, and within the spinal cord PrP could be traced in nerve tracts as far as the cerebral cortex. Similar patterns of PrP immunoreactivity were seen in two symptomatic and 18 apparently healthy lemurs in three different French primate centers, all of which had been fed diets supplemented with a beef protein product manufactured by a British company that has since ceased to include beef in its veterinary nutritional products. This study of BSE-infected lemurs early in their incubation period extends previous pathogenesis studies of the distribution of infectivity and PrP in natural and experimental scrapie. The similarity of neuropathology and PrP immunostaining patterns in experimentally infected animals to those observed in both symptomatic and asymptomatic animals in primate centers suggests that BSE contamination of zoo animals may have been more widespread than is generally appreciated.
Fast Charging of Li-Ion Cells: Part III. Relaxation Dynamics and Trap-Controlled Lithium Ion Transport (2019)

Fast charging of Li-ion batteries would ease consumer concerns regarding refueling time of electric vehicles. In this series of articles, we are systematically examining the effects of high currents flowing through the cell. Here we consider open-circuit relaxation dynamics for cell voltage and individual electrode potentials after abrupt termination of steady-state charging currents (1-6C) or short current pulses (&lt; 30 s) of either polarity (to 16C). We demonstrate that dispersive kinetics observed after these current perturbations become faster for higher currents applied before the rest period. Our observations indicate that the voltage relaxation behaviors (i) depend on the current during charge, and less so on the state of charge, (ii) display universal stretched-exponential kinetics, (iii) can be induced by a short current pulse, (iv) require a minimum amount of charge transfer during the pulse, and (v) originate mainly from the oxide cathode. Trap controlled Li + ion transport through a partially disordered oxygen-depleted subsurface layer in the cathode is suggested as a possible origin for the relaxation behavior. The slow multidecadal responses to high currents can cause the nonlinearities observed during rapid charging of the electrochemical cells, reported in Part 2 of this series.
Introduction to the Workshop on Current Issues in Feeding the Normal Infant (1985)

Gestation and lactation form a biologic continuum during which nutrients, protective factors, and growth modulators are transferred from mother to offspring. Because placental transfer ceases at birth, these placental functions must be maintained by feeding. It has become accepted as axiomatic that breast-feeding by a healthy mother for some time after birth is the biologic norm for the healthy term infant. However, the apparent success of modern commercially prepared formulas in the Western world has raised questions in the minds of some pediatricians and infant nutritionists about this axiom. Certainly, it cannot be argued on teleological grounds alone that because a particular constituent is present in human milk that it is, therefore, needed by the infant. Scientific questions about human milk can be formulated, and the evidence should be subjected to the same scrutiny as any other such question. During this first year of postnatal life, many biochemical adaptations are taking place. Those in the gastrointestinal tract and the immune system are especially important in bridging the transition between gestation and lactation, on the one hand, and independent postnatal life, on the other. In early infancy we must consider the role of human milk v formula and of whey-predominant v caseinpredominant formulas in the light of our newer knowledge of these adaptations. Both in the human and in animals, biochemical adaptations during the fetal and perinatal periods have been more extensively studied than those during the weaning period. Indeed, the data on which to make nutritional judgments during the later periods of infancy are scant.
A giant air shower array in Nord Rhein Westfalen (2001)

A proposal is presented to construct a very large air shower array in the densely populated central area of Nord-Rhein-Westfalen (NRW). The aim would be to reach a size of approximately 4000 km$^2$ to study the highest energy end of the all particle cosmic ray spectrum, as it is accessible in the northern hemisphere.
CT and MR imaging appearances of an extraosseous calcifying epithelial odontogenic tumor (Pindborg tumor). (2000)

We herein report a rare case of extraosseous calcifying epithelial odontogenic tumor with local aggressive behavior. CT and MR imaging showed the distinctive appearances of this histologic entity. We briefly discuss the radiologic features of calcifying epithelial odontogenic tumor and the relevant literature.
d‐ und r‐Arabinose (1899)

Iriteressnnt diirftr es seiii, iiahrren Bufschluss d n i iiber zu erlangen,
An Intrinsic Coordinate System of the Developing Human Brain (2001)

Magnetic resonance imaging of newborn infants with gestational age ranging from 24 to 40 weeks indicates majordevelopmental changes in the human brain over this time period [1]. Assessment of normal and abnormal anatomicalvariability requires a coordinate system enabling inter-subjectcomparison [2,3,4]. We present a method for identifyingan intrinsic coordinate system of the developing brain by applying a minimum entropy criterion to determine afﬁnetransformations to bring a group of subject scans into alignment.