gebhart/patrepeval huggingface dataset:
Simulation and optimization of a magnetic frequency mixing detection system of magnetic nanoparticles for immunoquantification in a microfluidic structure (2016)

International audience
The In Vitro and Ex Vivo Antiplatelet Effect of TRK-100, a Stable Prostacyclin Analog, in Several Species (1988)

Effect of TRK-100, a stable PGI2 analog, on platelet function was tested in vitro and ex vivo. TRK-100 at the dose range of 0.5–300 nM inhibited platelet aggregation induced by arachidonic acid, adenosine 5’-diphosphate and collagen in several species including human platelets. The potency of TRK-100 was 1/2 to 1/5 that of PGI2. The effect was strong in human and cat platelets. In conscious rabbits and rats, oral TRK-100 at the dose range of 0.1–1 mg/kg inhibited ex vivo platelet aggregation up to 80% in the rat and 70% in the rabbit, and the effect lasted over 5 hr. However, in both species, the effect on blood pressure was minimal. In anesthetized rabbits, inhibition of platelet aggregation was the same level as in the conscious animal, but blood pressure depression was observed. Cyclic AMP levels of human platelets, 2 min after incubation, was elevated up to 2.4 μM/109 platelets by 100 ng/ml of PGI2 and 1.5 μM by 100 ng/ml of TRK-100. It was shown that TRK-100 has a potent antiplatelet effect both in vitro and ex vivo in many species through elevation of platelet cAMP. These results suggest that TRK-100 may be a potential oral antithrombotic drug.
Experimental and Modeling Study on the Thermal Decomposition of Jet Propellant-10 (2014)

Jet Propellant-10 (JP-10) pyrolysis is performed in a continuous flow tubular reactor near atmospheric pressure in the temperature range of 930–1080 K, a conversion range of 4–94%, and two dilution levels of 7 and 10 mol % JP-10 in nitrogen. Identification and quantification of the pyrolysis products of JP-10 are based on online two-dimensional gas chromatography with a time-of-flight mass spectrometer and a flame ionization detector. JP-10 starts to react at 930 K and is fully converted at 1080 K. Among the more than 70 species up to C14H10 that were identified and quantified, tricyclo[5.2.1.02,6]dec-4-ene was identified for the first time, indicating the importance of bimolecular H-abstraction reactions in the consumption of JP-10. Critical assessment of the experimental data with the JP-10 combustion model by Magoon et al. [Magoon, G. R.; Aguilera-Iparraguirre, J.; Green, W. H.; Lutz, J. J.; Piecuch, P.; Wong, H. W.; Oluwole, O. O. Detailed chemical kinetic modeling of JP-10 (exo-tetrahydrodicyclopentadiene) high-temperature oxidation: Exploring the role of biradical species in initial decomposition steps. Int. J. Chem. Kinet. 2012, 44 (3), 179−193] showed that the model predictions of JP-10 agree reasonably well. The newly acquired and highly detailed experimental data help in understanding the thermal decomposition chemistry of JP-10 and can be used to validate future kinetic models of JP-10 pyrolysis.
A nonparametric approach to the analysis of longitudinal data via a set of level crossing problems with application to the analysis of microarray time course experiments (2005)

Here we develop a completely nonparametric method for comparing two groups on a set of longitudinal measurements. No assumptions are made about the form of the mean response function, the covariance structure or the distributional form of disturbances around the mean response function. The solution proposed here is based on the realization that every longitudinal data set can also be thought of as a collection of survival data sets where the events of interest are level crossings. The method for testing for differences in the longitudinal measurements then is as follows: for an arbitrarily large set of levels, for each subject determine the first time the subject has an upcrossing and a downcrossing for each level. For each level one then computes the log rank statistic and uses the maximum in absolute value of all these statistics as the test statistic. By permuting group labels we obtain a permutation test of the hypothesis that the joint distribution of the measurements over time does not depend on group membership. Simulations are performed to investigate the power and it is applied to the area that motivated the method-the analysis of microarrays. In this area small sample sizes, few time points and far too many genes to consider genuine gene level longitudinal modeling have created a need for a simple, model free test to screen for interesting features in the data.
MultiCruise: Eco-Lane Selection Strategy with Eco-Cruise Control for Connected and Automated Vehicles (2021)

Connected and Automated Vehicles (CAVs) have real-time information from the surrounding environment by using local on-board sensors, V2X (Vehicle-to-Everything) communications, pre-loaded vehicle-specific lookup tables, and map database. CAVs are capable of improving energy efficiency by incorporating these information. In particular, Eco-Cruise and Eco-Lane Selection on highways and/or motorways have immense potential to save energy, because there are generally fewer traffic controllers and the vehicles keep moving in general. In this paper, we present a cooperative and energy-efficient lane-selection strategy named MultiCruise, where each CAV selects one among multiple candidate lanes that allows the most energy-efficient travel. MultiCruise incorporates an Eco-Cruise component to select the most energy-efficient lane. The Eco-Cruise component calculates the driving parameters and prospective energy consumption of the ego vehicle for each candidate lane, and the Eco-Lane Selection component uses these values. As a result, MultiCruise can account for multiple data sources, such as the road curvature and the surrounding vehicles' velocities and accelerations. The eco-autonomous driving strategy, MultiCruise, is tested, designed and verified by using a co-simulation test platform that includes autonomous driving software and realistic road networks to study the performance under realistic driving conditions. Our experimental evaluations show that our eco-autonomous Mul-tiCruise saves up to 8.5% fuel consumption.
Domain-Structured N,N-Derivatized Hydrazines as Inhibitors of Ribonucleoside Diphosphate Reductase:  Redox-Cycling Considerations (1999)

Eight analogues of 1-[5-halogenosalicylidene]-2-[2'-pyridinoyl]hydrazine and -[2'-pyridyl]hydrazine, four of 1-[pyridoxylidene]-2-[2'-pyridinoyl]hydrazine, seven of 1-[pyridoxylidene]-2-[2'-pyridyl]hydrazine, and one each of 1, 2-bis[pyridoxylidene]diaminoethane and bis[pyridoxylidenehydrazino]phthalazine were synthesized. Their solutions in DMF were assayed for activity against the metalloenzyme ribonucleoside diphosphate reductase (RdR), prepared from a subcutaneously growing murine tumor (sarcoma 180) implanted in B6D2F3 male mice. The 14C-labeled CDP reductase was assayed by the modified method of Takeda and Weber, in which [14C]cytidine was separated from deoxycytidine by thin-layer chromatography (TLC) on cellulose foil. Distribution of radioactivity was assessed with an automatic TLC linear analyzer. Of the 31 compounds tested, 13 were essentially inactive, 7 were highly active against RdR, and the remaining 20 were slightly more active than hydroxyurea (used as a reference compound). The mechanism of inhibition is discussed in terms of three alternative pathways, initiated by sequestration of iron embedded in the R1 subunit of the metalloenzyme to form a C-centered chelate radical (via redox cycling). Alternatively, the latter could either reduce the tyrosyl radical or intercept radicals generated in the reduction process.
Importance of the conserved nucleotides around the tRNA-like structure of Escherichia coli transfer-messenger RNA for protein tagging (2001)

A bacterial RNA functioning as both tRNA and mRNA, transfer-messenger RNA (tmRNA) rescues stalled ribosomes and clears the cell of incomplete polypeptides. For function, Escherichia coli tmRNA requires an elaborate interplay between a tRNA-like structure and an internal mRNA domain that are connected by a 295 nt long compact secondary structure. The tRNA-like structure is surrounded by 16 unpaired nt, including 10 residues that are >95% conserved among the known 140 tmRNA sequences. All these residues were mutated to define their putative role(s) in trans-translation. Both the extent of aminoacylation and the alanine incorporation into the tag sequence, reflecting the two functions of tmRNA, were measured in vitro for all variants. As anticipated from the low sequence conservation, mutating positions 8-12 and position 15 affects neither aminoacylation nor protein tagging. Mutating a set of two conserved positions 13 and 14 abolishes both functions. Probing the solution conformation indicates that this defective mutant adopts an alternate conformation of its acceptor stem that is no more aminoacylatable, and thus inactive in protein tagging. Selected point mutations at the conserved nucleotide stretches 16-20 and 333-335 seriously impair protein tagging with only minor changes in their solution conformations and aminoacylation. Point mutations at conserved positions 19 and 334 abolish trans-translation and 70S ribosome binding, although retaining nearly normal aminoacylation capacities. Two proteins that are known to interact with tmRNA were purified, and their interactions with the defective RNA variants were examined in vitro. Based on phylogenetic and functional data, an additional structural motif consisting of a quartet composed of non-Watson-Crick base pairs 5'-YGAC-3':5'-GGAC-3' involving some of the conserved nucleotides next to the tRNA-like portion is proposed. Overall, the highly conserved nucleotides around the tRNA-like portion are maintained for both structural and functional requirements during evolution.
Demo Abstract: A Research Platform for Real-World Evaluation of Routing Schemes in Delay Tolerant Social Networks (2017)

Over the past decade, online social networks (OSNs) such as Twitter and Facebook have thrived and experienced rapid growth to over 1 billion users. A major evolution would be to leverage the characteristic of OSNs to evaluate the effectiveness of the many routing schemes developed by the research community in real-world scenarios. In this demo, we showcase AlleyOop Social, a secure delay tolerant networking research platform that serves as a real-life mobile social networking application for iOS devices. AlleyOop Social allows users to interact, publish messages, and discover others that share common interests in an intermittent network using Bluetooth, peer-to-peer WiFi, and infrastructure WiFi. The research platform serves as an overlay application for the SOS middleware which allows different routing schemes to be easily implemented relieving the burden of security and connection establishment.
Red blood cell deformability and aggregation in chronic venous disease patients with varicose veins Odkształcalność i agregacja krwinek czerwonych u pacjentów z przewlekłą niewydolnością żylną kończyn dolnych z towarzyszącymi żylakami (2013)

Summary Red blood cells’ (RBC) rheological properties are disturbed in chronic venous disease (CVD). The aim of the study was to compare deformability and aggregation of erythrocytes taken from the varicose vein and the antecubital vein of patients with chronic venous disease. Blood samples were taken from twelve CVD patients presenting clinical, aetiological, anatomical and pathological elements (CEAP) stages II and III. Blood was sampled from varicose veins and antecubital veins of patients (as control). Deformability and aggregation of RBC were analysed with a Laser-assisted Optical Rotational Cell Analyser (LORCA). A significant increase in deformability was found in varicose vein RBC for shear stress values 4.24, 8.23 and 15.96 Pa as compared to RBC from the antecubital vein. The aggregation index was significantly lower and aggregation halftime was significantly increased for RBC taken from antecubital veins than for RBC from varicose veins. In conclusion, RBC taken from varicose and antecubital veins of CVD patients are not entirely rheologically comparable and show different deformability and aggregation. Varicose vein RBC are more deformable and show a higher tendency for aggregation than antecubital vein RBC. Perhaps the deformability of varicose vein RBC has been increased as a compensation mechanism in subjects with CVD, due to increased resistance in their microcirculation.
Corrosion resistant tests under load on stainless austenitic steels in controlled aqueous medium (1973)

Results are presented concerning the corrosion behavior under load in aqueous media of some stainless austenitic steels of practical interest for the nuclear industry. The influences of carbon content and of the thermal sensitizing treatment on corrosion under load were studied, and it was found that, in the case of unstabilized and sensitized steels, the increase in carbon content augments the susceptibility to corrosive fissuring under load. The morphology and structure of the oxide film formed on tensioned samples is described. (auth)
Using Corbino disk sample geometry to separate quasiparticle and vortex motion contributions to the mixed state dissipation of YBCO (1999)

A method, using a Corbino disk sample geometry, is described and applied to study of resistive tails of sintered $YBCO$. When the transport current passes radially from the rim of the disk sample to its center, the two component potential drop signal is detected below $T_c$, which is due to (i) quasiparticles $W_q$ and (ii) vortex-core-motion related contribution $W_{ϕ}$. When the contact pairs for $W$ are placed radially, $W_q(r)$ and $W_{ϕ}(r)$ are found to follow the markedly distinctive functional dependences, providing a unique possibility to deconvolute the relative strengths of both contributions. The results obtained suggest that the mixed state dissipation of high-$T_c$ superconductors is strongly influenced by the quasiparticle excitations.
THE STRUCTURE OF FACTOR ORACLES (2007)

The factor oracle is a relatively new data structure for the set of factors of a string. It has been introduced by Allauzen, Crochemore, and Raffinot in 1999. It may recognize non-factors (hence the name "oracle") but its implementational simplicity and experimental behaviour are stunning; factor oracle based string matching has been conjectured optimal on average. However, its structure is not well understood. We take important steps in clarifying its structure by explaining how it can be obtained as a quotient of the trie of the set of factors. When seen this way, all known properties of the factor oracle become simple observations. Also, we introduce a framework where various oracles can be compared. The factor oracle is better than several natural ones obtained from the trie of the set of factors, the suffix and the factor automata, respectively.
Transformation for the unified linear analysis of optics and electronics (1985)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text William N. Peters and Dean Scribner, "Transformation for the unified linear analysis of optics and electronics," Appl. Opt. 24, 1247-1248 (1985) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
The Candidate: What It Takes to Win—and Hold—the White House, by Samuel L. Popkin (2013)

Campaigns are won by candidates who have loyal, adept staff who help communicate their visions to the public. When experienced and charismatic personalities fail to acquire such team support, their...
Mapping Patient Encounters in Breast Cancer Care (2023)

Encounter utilization in breast cancer care persists 3 years after index diagnosis and is influenced by overall stage and treatment characteristics, including receipt of breast reconstruction. These results may inform the design of episode durations within value-based models and institutional resource allocation for breast cancer care.
Node importance to community based caching strategy for information centric networking (2018)

Summary Information Centric Networking (ICN) is a novel future network architecture that is focusing on content distribution. Its ubiquitous caching schemes can improve network performance. In this paper, we propose a node importance to community based caching scheme with network coding in ICN, which is named as NICNC. For each community, content router makes cache decision depending on its node importance to community to make content cached more reasonable in temporal and spatial distribution. Moreover, by applying network coding into ICN, one coded blocks containing information of multiple chunks can satisfy multiple interests for different chunks sent by different consumers. This can significantly enhance cache diversity and cache hit rate without increasing cache capacity. Experimental results show that our scheme can improve the network performance at many aspects, such as average download time, cache hit rate, and instantaneous hop reduction rate.
Comments on "Computer simulation of frequency swept imaging" (1977)

It is demonstrated that the swept frequency hologram obtained in the above paper by Farhat, Dzekov, and Le Det exhibits anamalous behavior and that, in general, their 2-D imaging process seems unacceptable.
A New Tool in Peptide Engineering: A Photoswitchable Stilbene‐type β‐Hairpin Mimetic (2005)

Peptide secondary structure mimetics are important tools in medicinal chemistry, as they provide analogues of endogenous peptides with new physicochemical and pharmacological properties. The development, synthesis, photochemical investigation, and conformational analysis of a stilbene-type beta-hairpin mimetic capable of light-triggered conformational changes have been achieved. In addition to standard spectroscopic techniques (nuclear Overhauser effects, amide temperature coefficients, circular dichroism spectroscopy), the applicability of self-diffusion measurements (longitudinal eddy current delay pulsed-field gradient spin echo (LED-PGSE) NMR technique) in conformational studies of oligopeptides is demonstrated. The title compound shows photoisomerization of the stilbene chromophore, resulting in a change in solution conformation between an unfolded structure and a folded beta-hairpin.
(Z)-1-(4-Methylphenyl)-2-(phenylsulfonyl)ethanone oxime (2012)

The mol-ecule of the title compound, C(15)H(15)NO(3)S, has a twisted U-shaped conformation: the twist occurs at the central C-S(=O)(2)-C-C-C unit and the benzene ring makes a dihedral angle of 28.74 (7)° with the phenyl ring. The S-C-C=N torsion angle is -88.95 (13)°. In the crystal, inversion dimers linked by pairs of O-H⋯N hydrogen bonds generate R(2) (2)(6) loops, and C-H⋯O hydrogen bonds connect the dimers into a three-dimensional network.
Progress on Fast Analytical Temperature Rising Elution Fractionation (ATREF) Technique for Practical Applications (2014)

Fast analytical temperature rising elution fractionation (ATREF) is a recently proposed method to evaluate the molecular structure of polyolefins with unimodal distributions. In this article, we compare the results obtained by this method and the classical slow cooling rate ATREF. An interpretation of previous results found in the literature is proposed in order to explain one of the limitations usually associated with this technique. Practical recommendations are given to build columns adapted to this technique and to efficiently adjust the method parameters.
IMPROVED HYBRID MODEL OF HMM/GMM FOR SPEECH RECOGNITION (2008)

In this paper, we propose a speech recognition engine using hybrid model of Hidden Markov Model \n(HMM) and Gaussian Mixture Model (GMM). Both the models have been trained independently and the \nrespective likelihood values have been considered jointly and input to a decision logic which provides net \nlikelihood as the output. This hybrid model has been compared with the HMM model. Training and testing has \nbeen done by using a database of 20 Hindi words spoken by 80 different speakers. Recognition rates achieved \nby normal HMM are 83.5% and it gets increased to 85% by using the hybrid approach of HMM and GMM.
Detection of surface carbon and hydrocarbons in hot spot regions of niobium superconducting rf cavities by Raman spectroscopy (2013)

Raman microscopy/spectroscopy measurements are presented on high purity niobium (Nb) samples, including pieces from hot spot regions of a tested superconducting rf cavity that exhibit a high density of etch pits. Measured spectra are compared with density functional theory calculations of Raman-active, vibrational modes of possible surface Nb-O and Nb-H complexes. The Raman spectra inside particularly rough pits in all Nb samples show clear differences from surrounding areas, exhibiting enhanced intensity and sharp peaks. While some of the sharp peaks are consistent with calculated NbH and ${\mathrm{NbH}}_{2}$ modes, there is better overall agreement with C-H modes in chain-type hydrocarbons. Other spectra reveal two broader peaks attributed to amorphous carbon. Niobium foils annealed to $&gt;2000\ifmmode^\circ\else\textdegree\fi{}\mathrm{C}$ in high vacuum develop identical Raman peaks when subjected to cold working. Regions with enhanced C and O have also been found by SEM/EDX spectroscopy in the hot spot samples and cold-worked foils, corroborating the Raman results. Such regions with high concentrations of impurities are expected to suppress the local superconductivity and this may explain the correlation between hot spots in superconducting rf (SRF) cavities and the observation of a high density of surface pits. The origin of localized high carbon and hydrocarbon regions is unclear at present but it is suggested that particular processing steps in SRF cavity fabrication may be responsible.
A proposal of multiplace hyperbaric chamber for animal experimentation and veterinary use (2008)

The development of the project enabled the construction of a hyperbaric chamber with security features and reliability comparable to those required by the legal and technical specifications of a hyperbaric chamber human use.
Thin film patterning by surface-plasmon-induced thermocapillarity (2007)

It is reported that standing surface-plasmon-polariton (SPP) waves can cause regular thickness undulations of thin polymethyl methacrylate (PMMA) films above a metallic substrate. Ripples, rings, and hillock arrays with long-range order were found. Numerical calculations reveal that periodic in-plane temperature profiles are generated in the PMMA due to the nonradiative damping of SPP interference patterns. Computer simulations on the temperature-gradient-driven mass transport confirm that thermocapillarity is the dominating mechanism of the observed surface patterning.
Cu-Ni Cermet Anodes for Direct Oxidation of Methane in Solid-Oxide Fuel Cells (2002)

We have examined the use of Cu-Ni alloys as anodes for the direct oxidation of methane in solid-oxide fuel cells (SOFC) at 1073 K. Ceramic-metal (cermet) composites having alloy compositions of 0, 10, 20, 50 and 100% Ni were exposed to dry methane at 1073 K for 1.5 h to demonstrate that carbon formation is greatly suppressed on the Cu-Ni alloys compared to that of pure Ni. Increased reduction temperatures also reduced the carbon formation on the alloys. The performance of a fuel cell made with a Cu(80%)-Ni(20%) cermet was tested in dry methane for 500 h and showed a significant increase in power density with time. Impedance spectra of similar fuel cells suggest that small carbon deposits are formed with time and that the increase in performance is due to enhanced electronic conductivity in the anode. Finally, the implications of the use of metal alloys for SOFC applications are discussed. © 2002 The Electrochemical Society. All rights reserved.