gebhart/patrepeval huggingface dataset:
Methylotrophic growth of a mutant strain of the acetogenic bacteriumEubacterium limosumthat uses acetate as co-substrate in the absence of CO2 (1994)

A mutant strain (the CO2− strain) of the acetogenic bacterium Eubacterium limosum was isolated by nutritional selection on a medium containing methanol and acetate but lacking CO2. The ability of the CO2− strain to grow on methanol/acetate without CO2 or other one-carbon compounds was stable through several transfers in the presence of CO2. The phenotypic difference between the parent and the mutant strain was the ability to support sustained growth in the absence of CO2 by consumption of acetate throughout the growth period. The maximal specific rate of acetate consumption (5 mmol C·g−1·h−1) was similar to that previously observed for a brief period early in the exponential growth phase of the parent strain but was maintained for a prolonged duration. The methanol consumption rate was considerably lower than in the presence of CO2 and was similar to the rate of acetate consumption, hence maintaining equilibrated reducing equivalent pools. The maximal growth rate (0.08 h−1) was lower than that of the parent strain and the optimal pH for growth was 6.5 instead of 7.4 in the presence of CO2. These acidic conditions enhanced the toxic effect of butyric acid, resulting in a more pronounced inhibition of growth, as seen by the decrease in YATP proportional to the accumulated butyric acid.
Contribution of α2 receptor subtypes to nerve injury‐induced pain and its regulation by dexmedetomidine (2001)

There is evidence that noradrenaline contributes to the development and maintenance of neuropathic pain produced by trauma to a peripheral nerve. It is, however, unclear which subtype(s) of alpha adrenergic receptors (AR) may be involved. In addition to pro-nociceptive actions of AR stimulation, alpha(2) AR agonists produce antinociceptive effects. Here we studied the contribution of the alpha(2) AR subtypes, alpha(2A), alpha(2B) and alpha(2C) to the development of neuropathic pain. We also examined the antinociceptive effect produced by the alpha(2) AR agonist dexmedetomidine in nerve-injured mice. The studies were performed in mice that carry either a point (alpha(2A)) or a null (alpha(2B) and alpha(2C)) mutation in the gene encoding the alpha(2) AR. To induce a neuropathic pain condition, we partially ligated the sciatic nerve and measured changes in thermal and mechanical sensitivity. Baseline mechanical and thermal withdrawal thresholds were similar in all mutant and wild-type mice; and, after peripheral nerve injury, all mice developed comparable hypersensitivity (allodynia) to thermal and mechanical stimulation. Dexmedetomidine reversed the allodynia at a low dose (3 microg kg(-1), s.c.) and produced antinociceptive effects at higher doses (10 - 30 microg kg(-1)) in all groups except in alpha(2A) AR mutant mice. The effect of dexmedetomidine was reversed by intrathecal, but not systemic, injection of the alpha(2) AR antagonist RS 42206. These results suggest that neither alpha(2A), alpha(2B) nor alpha(2C) AR is required for the development of neuropathic pain after peripheral nerve injury, however, the spinal alpha(2A) AR is essential for the antinociceptive effects of dexmedetomidine.
Left-ventricular volumes and ejection fraction from cardiac ECG-gated 15O-water positron emission tomography compared to cardiac magnetic resonance imaging using simultaneous hybrid PET/MR (2022)

LV volumes and EF can be calculated by first-pass analysis of a <sup>15</sup>O-water PET scan with high accuracy and comparable precision as with CMR.
Alumina‐based water‐dispersible conducting nanocomposites of polypyrrole and polypyrrole with poly(N‐vinylcarbazole) (2003)

Abstract Water‐dispersible nanocomposites of polypyrrole with Al 2 O 3 (PPYAl 2 O 3 ) and of poly( N ‐vinylcarbazole) with Al 2 O 3 (PNVCAl 2 O 3 ) were prepared in an aqueous medium. Nanocomposites involving binary polymer systemsPNVC(PPYAl 2 O 3 ) and PPY(PNVCAl 2 O 3 )were prepared by precipitating PNVC or PPY onto a suspension of PPYAl 2 O 3 or PNVCAl 2 O 3 , respectively. The incorporation of the polymers in the composites was confirmed by Fourier transform infrared analyses. Scanning electron microscopy analyses revealed distinct morphological features of the composites. Transmission electron microscopy analyses of the PPYAl 2 O 3 , PNVCAl 2 O 3 , and PPY(PNVC Al 2 O 3 ) composites confirmed the formation of spherical particles in the nanometer range. Thermogravimetric and differential thermal analyses revealed the stability order as: PNVCAl 2 O 3 &gt; PNVC(PPYAl 2 O 3 ) &gt; PPY(PNVCAl 2 O 3 ) &gt; PPYAl 2 O 3 . Direct current conductivity values of the PPYAl 2 O 3 , PNVC(PPYAl 2 O 3 ), and PPY(PNVCAl 2 O 3 ) composites were on the order of 2.8 × 10 −4 , 1.7 × 10 −5 , and 4.5 × 10 −6 (S/cm), respectively. These nanocomposites dispersed in water, with stability decreasing in the order: PPYAl 2 O 3 (∼40 h) &gt; PNVC(PPYAl 2 O 3 ) (30 h) &gt; PPY(PNVCAl 2 O 3 ) (20 h), and in the presence of polyvinylpyrrolidone a permanently stable suspension was obtained in all cases. The dispersibility appeared to be higher when the polymerization was conducted in a suspension containing a higher amount of Al 2 O 3 . © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 90: 1058–1065, 2003
Replacement of MDA with more oxidatively stable diamines in PMR-polyimides (1985)

Studies are performed to investigate the effect of substituting 4,4'-oxydianiline and 1,1-bis(4-aminophenyl)-1-phenyl-2,2,2-trifluoroethane for the 4,4'-methylenedianiline in PMR polyimide matrix resin. Graphite fiber reinforced composites are fabricated from unsized Celion 6000 and PMR-polyimide matrix resins having formulated molecular weights in the range of 1500 to 2400. The composite processing characteristics are investigated and the initial room temperature and 316 C (600 F) composite mechanical properties are determined. Comparative 316 C composite weight losses and 316 C mechanical properties retention after prolonged 316 C air exposure are also determined.
New insights into the S-nitrosothiol–ascorbate reaction. The formation of nitroxyl (2009)

Although the ascorbate-dependent reduction of S-nitrosothiol to the corresponding thiol function is frequently used for analyzing S-nitrosocysteinyl residues in proteins, it proceeds with low yields. Our re-investigation of the ascorbate-S-nitrosothiol reaction demonstrates now the intermediacy of nitroxyl (HNO/3NO-) that is highly effective in oxidizing thiols. The occurrence of the HNO reporter molecule, i.e., N2O, during and after reaction was unequivocally demonstrated by 15N NMR. The yield of HNO from the S-nitrosoglutathione-ascorbate reaction was determined with the aid of a Mn(III)-complex to 60%, a value that was significantly higher than the one of nitric oxide formation (48%) at physiological pH. The same HNO yield was observed with a S-nitrosothiol bound to a protein (i.e., S-nitroso-papain). With the known chemistry of nitroxyl, it was possible to optimize the experimental conditions so that the GSNO-ascorbate reaction yielded stoichiometric amounts of glutathione after a reaction period of 1 min.
THE STOPPING POWER OF SOME SOLID HYDROCARBONS FOR LOW ENERGY PROTONS AND HELIUM IONS. (1958)

Abstract not available
The Integrated Neurophotonics Paradigm (2022)

Integrated neurophotonics can surmount limitations of existing methodologies to enable fast and dense large-scale functional imaging of neuronal activity from within the brain itself. Implantable lens-less nanophotonic arrays yield cellular resolution at arbitrary brain depths.
Copper-Catalyzed Asymmetric Conjugate Additions of Bis(pinacolato)diboron and Dimethylzinc to Acyl-N-methylimidazole Michael Acceptors: A Highly Stereoselective Unified Strategy for 1,3,5,...n (OH, Me) Motif Synthesis (2019)

A unified strategy for the construction of prevalent 1,3,5,... n (OH, Me) motifs based on consecutive copper-catalyzed asymmetric conjugate borylation (ACB) and methylation (ACA) reactions involving α,β-unsaturated 2-acyl- N-methylimidazoles is described. Good yields and high diastereoselectivities have been obtained in ACA and ACB reactions for both matched and mismatched pairs as illustrated in the synthesis of syn/ anti and anti/ anti (Me, OTBS, Me) and (OH, OTBS, Me) motifs.
Energy-aware cooling for hot-water cooled supercomputers (2015)

Hot-water liquid cooling is a key technology in future green supercomputers as it maximizes the cooling efficiency and energy reuse. However the cooling system still is responsible for a significant percentage of modern HPC power consumption. Standard design of liquid-cooling control relies on rules based on worst-case scenarios, or on CFD simulation of portion of the entire system, which cannot account for all the real supercomputer working conditions (workload and ambient temperature). In this work we first introduce an analytical model, based on lumped parameters, which can effectively describe the cooling components and dynamics, and can be used for analysis and control purposes. We then use it to design an energy-optimal control strategy which is capable to minimize the pump and chiller power consumption while, meeting the supercomputer cooling requirements. We validate the method with simulation tests, taking data from a real HPC cooling mechanism, and comparing the results with state-of-the-art commercial cooling system control strategies.
Por amor al arte (2020)

El arte posibilita que la intervencion social se situe en un mundo creativo y bello. Esto provoca que el encuentro con las emociones y las dificultades sea mas amable con las personas y con el entorno, favoreciendo la inclusion.
The respiratory arsenate reductase fromBacillus selenitireducensstrain MLS10 (2003)

The respiratory arsenate reductase from the Gram-positive, haloalkaliphile, Bacillus selenitireducens strain MLS10 was purified and characterized. It is a membrane bound heterodimer (150 kDa) composed of two subunits ArrA (110 kDa) and ArrB (34 kDa), with an apparent K(m) for arsenate of 34 microM and V(max) of 2.5 micromol min(-1) mg(-1). Optimal activity occurred at pH 9.5 and 150 g l(-1) of NaCl. Metal analysis (inductively coupled plasma mass spectrometry) of the holoenzyme and sequence analysis of the catalytic subunit (ArrA; the gene for which was cloned and sequenced) indicate it is a member of the DMSO reductase family of molybdoproteins.
Monitoring Biomimetic Platinum Nanocluster Formation Using Mass Spectrometry and Cluster‐Dependent H2 Production (2008)

Je nach Größe: Die Bildung von Platin-Nanoclustern im Innern von Proteinkäfigen (LiDps-Protein) wurde durch nichtkovalente Massenspektrometrie untersucht. Die eingeschlossenen Pt-Cluster katalysieren die Wasserstoffbildung in Gegenwart eines Iridium-Photosensibilisators (PS) (siehe Schema; TEOA=Triethanolamin), und ihre katalytische Aktivität ist größenabhängig. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2008/z802481_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Numerical study on plasma confinement by multipolar magnetic fields (2003)

Summary form only given, as follows. Multipolar plasma chambers have widely been used for research on basic and applied researches on low temperature plasmas. The multipolar confinement realizes enhanced plasma density, homogeneous plasma of a large volume, and quiescent plasmas. However, detailed theoretical studies on the multipolar confinement are few.
Methylseleninic Acid Enhances Taxane Drug Efficacy against Human Prostate Cancer and Down-Regulates Antiapoptotic Proteins Bcl-XL and Survivin (2008)

MSeA enhanced the efficacy of paclitaxel against HRPCa in vitro and in vivo, at least in part, by down-regulating the basal and paclitaxel-induced expression of both Bcl-XL and survivin to increase caspase-mediated apoptosis. MSeA may be a novel agent to improve taxane combination therapy.
Using differential evolution to optimize 'learning from signals' and enhance network security (2011)

Computer and communication network attacks are commonly orchestrated through Wireless Access Points (WAPs). This paper summarizes proof-of-concept research activity aimed at developing a physical layer Radio Frequency (RF) air monitoring capability to limit unauthorized WAP access and improve network security. This is done using Differential Evolution (DE) to optimize the performance of a "Learning from Signals" (LFS) classifier implemented with RF "Distinct Native Attribute" (RF-DNA) fingerprints. Performance of the resultant DE-optimized LFS classifier is demonstrated using 802.11a WiFi devices under the most challenging conditions of intra-manufacturer classification, i.e., using emissions of like-model devices that only differ in serial number. Using identical classifier input features, performance of the DE-optimized LFS classifier is assessed relative to a Multiple Discriminant Analysis / Maximum Likelihood (MDA/ML) classifier that has been used for previous demonstrations. The comparative assessment is made using both Time Domain (TD) and Spectral Domain (SD) fingerprint features. For all combinations of classifier type, feature type, and signal-to-noise ratio considered, results show that the DE-optimized LFS classifier with TD features is superior and provides up to 20% improvement in classification accuracy with proper selection of DE parameters.
Prototype carbon nitrides similar to the symmetric triangular form of melon (2001)

Solid polymerization of 2,5,8-tricarbodiimide-tris-s-triazine potassium salt (potassium melonate) and 2,5,8-trichloro-tris-s-triazine (cyameluryl trichloride) gave a symmetric triangular form of a prototype carbon nitride which is deammonation-polycondensed with fifteen 2,5,8-triamino-tris-s-triazine molecules.
The Reaction of Chlorine Dioxide with Triethylamine in Aqueous Solution1 (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Reaction of Chlorine Dioxide with Triethylamine in Aqueous Solution1David H. Rosenblatt, Albert J. Hayes Jr., Bernice L. Harrison, Richard A. Streaty, and Kenneth A. MooreCite this: J. Org. Chem. 1963, 28, 10, 2790–2794Publication Date (Print):October 1, 1963Publication History Published online1 May 2002Published inissue 1 October 1963https://doi.org/10.1021/jo01045a072RIGHTS & PERMISSIONSArticle Views485Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (674 KB) Get e-Alerts Get e-Alerts
The Present Challenge of Transonic Compressor Blade Design (2019)

The flow through a transonic compressor cascade shows a very complex structure due to the occurring shock waves. In addition, the interaction of these shock waves with the blade boundary layer inherently leads to a very unsteady flow behavior. The aim of the current investigation is to quantify this behavior and its influence on the cascade performance as well as to describe the occurring transonic flow phenomena in detail. Therefore, an extensive experimental investigation of the flow in a transonic compressor cascade has been conducted within the transonic cascade wind tunnel of DLR Institute of Propulsion Technology at Cologne. In this process, the flow phenomena were thoroughly examined for an inflow Mach number of 1.21. The experiments investigate both the laminar and the turbulent shock wave boundary layer interaction within the blade passage and the resulting unsteady behavior. The experiments show a fluctuation range of the passage shock wave of about 10% chord for both cases, which is directly linked with a change of the inflow angle and of the operating point of the cascade. Thereafter, Reynolds-averaged Navier–Stokes (RANS) simulations have been performed aiming at the verification of the reproducibility of the experimentally examined flow behavior. Here, it is observed that the dominant flow effects are not reproduced by a steady numerical simulation. Therefore, a further unsteady simulation has been carried out to capture the unsteady flow behavior. The results from this simulation show that the fluctuation of the passage shock wave can be reproduced but not in the correct magnitude. This leads to a remaining weak point within the design process of transonic compressor blades because the working range will be overpredicted. The resulting conclusion of this study is that the use of scale-resolving methods such as LES or the application of DNS is necessary to correctly predict unsteadiness of the transonic cascade flow and its impact on the cascade performance.
Transition in the Infinite Swept Attachment Line Boundary Layer (1979)

Summary The transition behaviour of the boundary layer which is formed along an infinite swept attachment line has been studied experimentally. Circular trip wires and turbulent flat plate boundary layers have been used as sources of disturbance and the range of parameters covered has been such that the results are directly applicable to full scale flight conditions. Simple criteria have been deduced which allow the state of the boundary layer to be determined for given geometric and free stream properties. Sample calculations for typical swept wing configurations suggest that the majority of civil aircraft will have turbulent attachment lines in the cruise and that subsequent relaminarisation in regions of favourable pressure gradient is unlikely.
Characterization of Crystallographic Structures Using Bragg-Edge Neutron Imaging at the Spallation Neutron Source (2017)

Over the past decade, wavelength-dependent neutron radiography, also known as Bragg-edge imaging, has been employed as a non-destructive bulk characterization method due to its sensitivity to coherent elastic neutron scattering that is associated with crystalline structures. Several analysis approaches have been developed to quantitatively determine crystalline orientation, lattice strain, and phase distribution. In this study, we report a systematic investigation of the crystal structures of metallic materials (such as selected textureless powder samples and additively manufactured (AM) Inconel 718 samples), using Bragg-edge imaging at the Oak Ridge National Laboratory (ORNL) Spallation Neutron Source (SNS). Firstly, we have implemented a phenomenological Gaussian-based fitting in a Python-based computer called iBeatles. Secondly, we have developed a model-based approach to analyze Bragg-edge transmission spectra, which allows quantitative determination of the crystallographic attributes. Moreover, neutron diffraction measurements were carried out to validate the Bragg-edge analytical methods. These results demonstrate that the microstructural complexity (in this case, texture) plays a key role in determining the crystallographic parameters (lattice constant or interplanar spacing), which implies that the Bragg-edge image analysis methods must be carefully selected based on the material structures.
In-cloud sulfate addition to single particles resolved with sulfur isotope analysis during HCCT-2010 (2014)

Abstract. In-cloud production of sulfate modifies aerosol size distribution, with important implications for the magnitude of indirect and direct aerosol cooling and the impact of SO2 emissions on the environment. We investigate which sulfate sources dominate the in-cloud addition of sulfate to different particle classes as an air parcel passes through an orographic cloud. Sulfate aerosol, SO2 and H2SO4 were collected upwind, in-cloud and downwind of an orographic cloud for three cloud measurement events during the Hill Cap Cloud Thuringia campaign in autumn 2010 (HCCT-2010). Combined SEM and NanoSIMS analysis of single particles allowed the δ34S of particulate sulfate to be resolved for particle size and type. The most important in-cloud SO2 oxidation pathway at HCCT-2010 was aqueous oxidation catalysed by transition metal ions (TMI catalysis), which was shown with single particle isotope analyses to occur primarily in cloud droplets nucleated on coarse mineral dust. In contrast, direct uptake of H2SO4 (g) and ultrafine particulate were the most important sources modifying fine mineral dust, increasing its hygroscopicity and facilitating activation. Sulfate addition to "mixed" particles (secondary organic and inorganic aerosol) and coated soot was dominated by in-cloud aqueous SO2 oxidation by H2O2 and direct uptake of H2SO4 (g) and ultrafine particle sulfate, depending on particle size mode and time of day. These results provide new insight into in-cloud sulfate production mechanisms, and show the importance of single particle measurements and models to accurately assess the environmental effects of cloud processing.
Micro-region transcriptomics of fixed human tissue using Pick-Seq (2021)

ABSTRACT Spatial transcriptomics and multiplexed imaging are complementary methods for studying tissue biology and disease. Recently developed spatial transcriptomic methods use fresh-frozen specimens but most diagnostic specimens, clinical trials, and tissue archives rely on formaldehyde-fixed tissue. Here we describe the Pick-Seq method for deep spatial transcriptional profiling of fixed tissue. Pick-Seq is a form of micro-region sequencing in which small regions of tissue, containing 5-20 cells, are mechanically isolated on a microscope and then sequenced. We demonstrate the use of Pick-Seq with several different fixed and frozen human specimens. Application of Pick-Seq to a human melanoma with complex histology reveals significant differences in transcriptional programs associated with tumor invasion, proliferation, and immuno-editing. Parallel imaging confirms changes in immuno-phenotypes and cancer cell states. This work demonstrates the ability of Pick-Seq to generate deep spatial transcriptomic data from fixed and archival tissue with multiplexed imaging in parallel.
Compact Four-Port Antenna Suitable for Portable MIMO Devices (2008)

In this letter, a compact four-port antenna structure with an area of 40 times 40 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and constructed from inexpensive FR-4 printed circuit board is described. The antennas operate at 2.48 GHz, and in terms of wavelengths have a compact overall area of 0.33 lambda <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">o</sub> times 0.33 lambda <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">o</sub> and this would usually result in very strong mutual coupling between the four antenna ports. However, in our proposed structure, the mutual coupling between antenna elements is better than -10 dB. Although this is not low mutual coupling by some standards it is suitable for multiple-input-multiple-output (MIMO) communications in portable devices as verified by our experimental MIMO testbed capacity results. Furthermore measurements and characteristics of the antenna structures are provided.