gebhart/patrepeval huggingface dataset:
Data from Endoglin (CD105) Contributes to Platinum Resistance and Is A Target for Tumor-Specific Therapy in Epithelial Ovarian Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Endoglin (CD105) is a membranous protein overexpressed in tumor-associated endothelial cells, chemoresistant populations of ovarian cancer cells, and potentially stem cells. Our objective was to evaluate the effects and mechanisms of targeting endoglin in ovarian cancer.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Global and membranous endoglin expression was evaluated in multiple ovarian cancer lines. &lt;i&gt;In vitro&lt;/i&gt;, the effects of siRNA-mediated endoglin knockdown with and without chemotherapy were evaluated by MTT assay, cell-cycle analysis, alkaline comet assay, γ-H2AX foci formation, and quantitative PCR. In an orthotopic mouse model, endoglin was targeted with chitosan-encapsulated siRNA with and without carboplatin.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Endoglin expression was surprisingly predominantly cytoplasmic, with a small population of surface-positive cells. Endoglin inhibition decreased cell viability, increased apoptosis, induced double-stranded DNA damage, and increased cisplatin sensitivity. Targeting endoglin downregulates expression of numerous DNA repair genes, including BARD1, H2AFX, NBN, NTHL1, and SIRT1. BARD1 was also associated with platinum resistance, and was induced by platinum exposure. &lt;i&gt;In vivo&lt;/i&gt;, antiendoglin treatment decreased tumor weight in both ES2 and HeyA8MDR models when compared with control (35%–41% reduction, &lt;i&gt;P&lt;/i&gt; &lt; 0.05). Endoglin inhibition with carboplatin was associated with even greater inhibitory effect when compared with control (58%–62% reduction, &lt;i&gt;P&lt;/i&gt; &lt; 0.001).&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Endoglin downregulation promotes apoptosis, induces significant DNA damage through modulation of numerous DNA repair genes, and improves platinum sensitivity both &lt;i&gt;in vivo&lt;/i&gt; and &lt;i&gt;in vitro.&lt;/i&gt; Antiendoglin therapy would allow dual treatment of both tumor angiogenesis and a subset of aggressive tumor cells expressing endoglin and is being actively pursued as therapy in ovarian cancer. &lt;i&gt;Clin Cancer Res; 19(1); 170–82. ©2012 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Study on the Model of Intercepting Decision for Multi Channel Surface to Air Missile Weapon System (2002)

Multi channel surface to air missile weapon system has the ability to lead multi missiles to catch multi objects. Air missile weapon system has been the main means for our national air defense. The accuracy and rationality of intercepting decision have a great effect on the result of air defense. Based on the 0-1 integer programming, the optimizing decision model is proposed in this paper. It can guarantee the rationality and utility of intercepting decision.
Migration Prediction On The Basis Of Prior Migratory Behavior: A Methodological Note (1969)

ABSTRACT Stochastic process analysis, particularly Markov chain dependence, may be utilized in a wide range of research situations where change through time is the focus of interest. This paper is concerned with the utility of Markov chain analysis in the prediction of future migration on the basis of past migratory behavior. Transition probability matrices, which were dependent on the respondent's migratory behavior in the preceding time interval, were utilized to predict migration in the following time interval for a series of 145 longitudinal case histories. Predictions were also obtained for selected age, educational, and occupational stratifications. Markov chain analysis, or a similar probability model, seems to provide a promising tool for studying the relationship between prior and expected migration, and for obtaining statements of migration probability. Since a high proportion of total migrations seem to be made by a limited segment of the population, the factor of past migratory behavior itself may be an important element in the identification of migration differentials and the prediction of future migration.
Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma (2015)

Meeting abstracts Glioblastoma (GBM) is a poorly immunogenic neoplasm treated with local radiation. Despite the standard of care, median survival remains low. Immunotherapy has synergized with stereotactic radiosurgery (SRS) in murine GBM, as radiation promotes a pro-inflammatory tumor
Fas-mediated apoptosis in mouse hepatocytes involves the processing and activation of caspases (1998)

The mechanism of Fas antigen-induced hepatocyte apoptosis was investigated. Using a monoclonal antibody directed against the Fas antigen, apoptosis was induced in freshly isolated murine hepatocytes within 90 minutes of antibody addition as assessed by plasma membrane bleb formation, chromatin condensation, and DNA fragmentation. Pretreatment of the cells with the caspase inhibitors, N-acetyl-Asp-Glu-Val-Asp aldehyde (Ac-DEVD-CHO), benzyloxycarbonyl-Val-Ala-DL-Asp-fluoromethylketone (Z-VAD-FMK), or Z-Asp-2,6-dichlorobenzoyloxymethylketone inhibited anti-Fas-mediated apoptosis. Likewise, the serine protease inhibitors, N-tosyl-L-phenyl chloromethyl ketone (TPCK) and 3,4-dichloroisocoumarin (DCI), prevented apoptosis, whereas N-tosyl-L-lysine chloromethyl ketone (TLCK), Ac-Leu-Leu-L-norleucinal, Ac-Leu-Leu-L-methional, and trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane were without effect. Examination of CED-3/caspase-3-related caspases revealed that pro-caspases-3 (CPP32) and -7 (Mch-3alpha) were rapidly processed after Fas antigen stimulation. Caspase-7 was further cleaved to form the catalytically active subunits. In contrast, the p17 subunit of caspase-3 was not detected, indicating slow formation or rapid degradation. The activation of CED-3-related caspases was further confirmed by an increase in the rate of Z-DEVD-7-amino-4-trifluoromethylcoumarin (Z-DEVD-AFC) hydrolysis that was sensitive to Ac-DEVD-CHO and was inhibited by pretreatment of the cells with TPCK but not by DCI. In contrast, no increase in the rates of hydrolysis of Z-YVAD-AFC, a substrate for caspase-1, was detected. Investigation of the in situ proteolytic cleavage of the CED-3 related caspases substrate, poly(ADP-ribose) polymerase, revealed that this protein was not degraded in hepatocytes undergoing Fas-mediated apoptosis. Taken together, our results show that processing of caspases, in particular, caspases-7 and -3, occurs during Fas-induced apoptosis of mouse hepatocytes and suggest a role of these proteases as well as serine protease(s) in the apoptotic response.
[18F]TRACK, a PET tracer for imaging of tropomyosin receptor kinases (Trk): Efficient radiosynthesis and preliminary evaluation in the TgF344‐AD rat model of Alzheimer’s disease (2023)

Abstract Background A family of tropomyosin receptor kinases (TrkA/B/C) plays important roles in the regulation of neuronal differentiation, growth, and survival via their interactions with neurotrophins. A growing body of literature suggests the downregulation of Trk in many neurodegenerative conditions of the central nervous system (CNS), including Alzheimer’s disease (AD). We recently reported the development of [ 18 F]TRACK, the PET tracers for in vivo imaging of TrkB and its first in‐human study. Here, we wish to report a fully automated GMP‐compliant radiosynthesis of [ 18 F]TRACK at high radiochemical purity (RCP) and molar activity and its preliminary evaluation in wild‐type and a transgenic rat model of AD. Method Radiosynthesis was performed using Scintomics GRP automated module via copper‐catalyzed 18 F‐fluorination of the chiral boron pinacolate precursor. Brain imaging in wild‐type (n = 3) and TgF344‐AD rat models (n = 2) at 23 months was performed on microPET Concord R4 scanner. Result [ 18 F]TRACK was synthesized with a 5.0±1.4% radiochemical yield not corrected for decay (activity range 95‐154 mCi) with &gt;99% RCP and molar activities of 250 ± 75 GBq/µmol (n = 6). The synthesis was fully automated and all batches passed quality control procedures, including chemical purity, sterility and pyrogenicity. The tracer showed moderate brain uptake in wild‐type rats with the highest accumulation in the thalamus (SUV max = 1.56 ± 0.28, 10 min post‐injection), consistent with the brain regional distribution in humans acquired in a parallel study. Preliminary data suggests lower tracer uptake in TgF344‐AD rat model of AD in thalamus, striatum and frontal cortex compared to wild‐type animals. Conclusion This study demonstrated the feasibility of the GMP‐compliant production of [ 18 F]TRACK in sufficient doses and molar activities for scanning multiple subjects per day or long range deliveries. Preliminary biodistribution studies showed moderate brain uptake of the tracer with preferential accumulation in the thalamus across species. These findings warrants further studies of Trk brain expression and its implication in neurodegenerative and psychiatric pathologies using [ 18 F]TRACK.
Creating Worldwide Software: Solaris International Developer's Guide (1997)

A guide to developing software for international markets, this text shows how to internationalize software so that it can support users worldwide with minimal additional effort. It covers a wide range of topics, including establishing locale environments, encoding character sets, displaying localized text, messaging for program translation, handling language input and localizing software once it has been internationalized. The book presents thorough coverage of internationalization techniques for CDE, Motif and X11. It also covers global Internet applications using Web browsers, HTML, MIME and NFS. Finally, it discusses the preparation of international documentation.
A novel actuation method of transporting droplets by using electrical charging of droplet in a dielectric fluid (2009)

We evaluate the feasibility of manipulating droplets in two dimensions by exploiting Coulombic forces acting on conductive droplets immersed in a dielectric fluid. When a droplet suspended in an immiscible fluid is located near an electrode under a dc voltage, the droplet can be charged by direct contact, by charge transfer along an electrically conducting path, or by both mechanisms. This process is called electrical charging of droplet (ECOD). This charged droplet may then be transported rapidly by exploiting Coulombic forces. We experimentally demonstrate electrical actuation of a charged droplet by applying voltage sequences. A charged droplet is two dimensionally actuated by following the direction of the electrical field signal. The droplet does not contact the surface of the microfluidic chip when it moves. This characteristic is very advantageous because treatments of the substrate surfaces of microfluidic chip become simpler. In order to test the feasibility of using ECOD in a droplet-based microreactor, electrocoalescence of two oppositely charged droplets is also studied. When two droplets approach each other due to Coulombic attraction, a liquid bridge is formed between them. We postulate that if the applied electric field is weaker than a certain critical level, the two droplets coalesce instantaneously when the charges are exchanged and redistributed through this liquid bridge.
Ultrasonic Attenuation in Thin Films (1963)

The loss factor of a liquid is usually referred to an effective infinite medium to avoid the influence of surface-tension effects. For finite samples, the surface tension and configuration influences the effective loss factor of the sample and when the physical shape of the specimen approaches a thin film these effects predominate. The effective loss factor of a number of liquids and semi-solid substances was measured for various film thicknesses. The data show the effect of film thickness on the loss factor and the effectiveness of the substance for ultrasonic damping. The arrangement employed used parallel-mounted quartz crystals in tuned circuits. The system was excited to resonance by a pulse and the response and decay of the system were recorded. By means of energy considerations, the effective loss factor of the sample was determined. [This work was sponsored by the U. S. Air Force.]
Effect of annealing on electronic carrier transport properties of gamma-irradiated AlGaN/GaN high electron mobility transistors (2014)

AlGaN/GaN High Electron Mobility Transistors were irradiated with 60Co gamma-ray doses from 100 Gy up to a maximum dose of 1000 Gy. After irradiation, the devices were annealed at 200° C for 25 minutes. Annealing of the gamma irradiated transistors show that partial recovery of device performance is possible at this temperature. The impact of irradiation and annealing on minority carrier diffusion length and activation energy were monitored through the use of the Electron Beam Induced Current method. Impact on transfer, gate, and drain characteristics were analyzed through current-voltage measurements.
Position Measurement of Multiple Microparticles in Hollow- Core Photonic Crystal Fiber by Coherent Optical Frequency Domain Reflectometry (2021)

Flying particle sensors in hollow-core photonic crystal fibers require accurate localization of the optically trapped microparticles. We report position measurement to micrometer- resolution, using optical frequency domain reflectometry, of two 1.65-µm-diameter polystyrene particles.
Photoluminescent Distinction among Plant Life Forms Using Phosphate Buffered Saline Extract Solutions (2006)

Photoluminescence of plant extract solutions has been investigated for discrimination of plant life forms (grasses, forbs, and shrubs) using principal component analysis (PCA). Clippings from each of six plant species representing three different plant life forms potentially found in the diets of free-ranging herbivores in the Chihuahuan Desert of North America were investigated for possible discernment. These plants included Sporobolus flexuosus (mesa dropseed, a grass), Pleuraphis mutica (tobosa, a grass), Dimorphocarpa wislizenii (spectacle pod, a forb), Sphaeralcea incana (pale globemallow, a forb), Flourensia cernua leaves (tarbush, a shrub), and Atriplex canescens leaves and stems (fourwing saltbush, a shrub). Emission spectra (370-600 nm) from phosphate buffered saline (PBS) extract solutions (pH 2.2, 7.5 and 12.5) were recorded for each plant with excitation at 365 nm. Use of PBS minimized chlorophyll interference. Discernment among plant life forms within these plant species was achieved.
Community Design (1983)

Click to increase image sizeClick to decrease image size Additional informationNotes on contributorsMark FrancisMark Francis is Associate Professor of Landscape Architecture and Director of the Center for Design Research, Department of Environmental Design, University of California, Davis. Educated in landscape architecture and urban design at the University of California, Berkeley and Harvard University, he has taught environmental psychology, landscape architecture and urban design at the City University of New York, Pratt Institute, Stavanger Technical University in Norway, and University of California, Berkeley. He has also been active in practicing and researching community design.
Particles Adsorbed at the Oil−Water Interface:  A Theoretical Comparison between Spheres of Uniform Wettability and “Janus” Particles (2001)

We consider the adsorption at an oil−water interface of spherical particles of two types. The first type has a homogeneous surface of uniform wettability. The second type, so-called “Janus” particles, has two surface regions of differing wettabilities. Homogeneous particles are strongly surface active but are not amphiphilic, whereas Janus particles are both surface active and amphiphilic. We present calculations to show how the particle amphiphilicity, tuned by variation of either the relative surfaces areas or the different wettabilities of the two surface regions on the particles, influences the strength of particle adsorption. Increasing the amphiphilicity of the particles produces a maximum of a 3-fold increase in surface activity for average contact angles around 90°. Unlike homogeneous surface particles, Janus particles remain strongly surface active for average contact angles approaching either 0 or 180°.
064 Brain Dynamics and Predictors of Female Hypoactive Sexual Desire Disorders (HSDD): Two Routes in the Top-Down Neurofunctional Self-Attention Model (SAM) of Desire (2018)

Hypoactive sexual desire disorder (HSDD) is one of the most prevalent female sexual health problems. Because of HSDD’ s negative impact on well-being and mental health, there is a crucial need to better understand the predictors and brain dynamics of HSDD. To date, it has been assumed that body image and spectatoring play a critical role in HSDD. It remains unclear, however, whether HSDD predictors are the same as a function of the patient’s mental state with respect to their social environment. Based on our work on brain dynamics and social self, we hypothesized that HSDD predictors would vary depending on whether a patient feels lonely or not. In this study, we conducted interviews querying various predictors of HSDD (e.g., body image, self-esteem, self-attention as a social object) in 27 female participants who met the DSM-V criteria of HSDD. Data from four subjects had to be excluded because of high ratio of missing data. Among these 23 patients with HSDD (as gauged with Sexual Desire Inventory, SDI, M = 23.78, SD = 11.39), 11 were lonely, and 12 were non-lonely.
Internal Structure of a Thin Film of Mixed Polymeric Micelles on a Solid/Liquid Interface (2008)

The adsorption of mixed micelles of poly(4-(2-amino hydrochloride-ethylthio)-butylene)- block-poly(ethylene oxide), PAETB 49- b-PEO 212 and poly(4-(2-sodium carboxylate-ethylthio)-butylene)- block-poly(ethylene oxide), PCETB 47- b-PEO 212 on solid/liquid interfaces has been studied with light, X-ray, and neutron reflectometry. The structure of the adsorbed layer can be described with a two-layer model consisting of an inner layer formed by the coacervate of the polyelectrolyte blocks PAETB 49 and PCETB 47 ( approximately 1 nm) and an outer layer of PEO 212 blocks ( approximately 6 nm). The micelles unfold upon adsorption forming a rather homogeneous flat layer that exposes its polyethylene oxide chains into the solution, thus rendering the surface antifouling after modification with the micelles.
Metal‐Containing Carbon Nitride Compounds: A New Functional Organic–Metal Hybrid Material (2009)

The electronic and optical functions of polymeric C3N4 can be easily modified by the inclusion of metal species such as Fe in its structure. The metal species lowers the bandgap and expands the light absorption of the material further into the visible region of the electromagnetic spectrum, while keeping a sufficient overpotential for carrying out oxidation reactions.
Location and Visualization of Working p-n and/or n-p Junctions by XPS (2016)

X-ray photoelectron spectroscopy (XPS) is used to follow some of the electrical properties of a segmented silicon photodetector, fabricated in a p-n-p configuration, during operation under various biasing configurations. Mapping of the binding energy position of Si2p reveals the shift in the position of the junctions with respect to the polarity of the DC bias applied. Use of squared and triangular shaped wave excitations, while recording XPS data, allows tapping different electrical properties of the device under normal operational conditions, as well as after exposing parts of it to harsh physical and chemical treatments. Unique and chemically specific electrical information can be gained with this noninvasive approach which can be useful especially for localized device characterization and failure analyses.
Adenosine-5'-Uronamides Rapidly Desensitize the Adenosine A2 Receptor in Coronary Artery (1993)

This study examined the structure-activity-relationship (SAR) of adenosine analogs and their ability to induce tachyphylaxis in vascular smooth muscle. Adenosine-5'-uronamides,5'-N-ethylcarboxamidoadenosine (NECA), 5'-N-cyclopropylcarboxamidoadenosine (CPCA), and 2-[p-(2-carboxyethyl)phenethylamino]-5'-N-ethylcarboxamidoadenosin e (CGS 21680), evidenced rapid desensitization of the A2 vasorelaxant response in porcine coronary artery in vitro whereas adenosine, 2-chloroadenosine (CAD), or 2-[(2-cyclohexylethyl)-amino]adenosine (CGS 22492) failed to do so. Tissues with prior exposure to NECA exhibited mitigated relaxation responses to adenosine, CAD, and NECA but not to isoproterenol, forskolin, pinacidil, or sodium nitroprusside (SNP). The data suggest that adenosine-5'-uronamides homologously desensitize the A2 receptor in porcine coronary artery smooth muscle.
Cell-based immunotherapy in gynecologic malignancies (2020)

Purpose of review To provide an update on cell-based immunotherapies in solid tumors particularly in gynecological cancers. Recent findings Recent clinical trial results demonstrate safety and tolerability of different cell therapies in gynecological cancers. Novel approaches, such as harnessing the cells of the innate immune system are also under investigation in a phase I trial. Summary Cell-based therapies are gaining widespread attention as evidenced by the increasing number of clinical trials encompassing both, innate and adaptive cells to target gynecological cancers. A majority of these therapeutic approaches are well tolerated and show promising results in early trials.
Table S1 from Molecular Analyses Support the Safety and Activity of Retroviral Replicating Vector Toca 511 in Patients (2023)

&lt;p&gt;Tg 511-11-01 (Study 11) dosing table.&lt;/p&gt;
Figure S4 from Immunologic Characterization and T cell Receptor Repertoires of Expanded Tumor-infiltrating Lymphocytes in Patients with Renal Cell Carcinoma (2023)

&lt;p&gt;Figure S4 shows representative gating strategies for the different marker expressions in the CD4+ and CD8+ T-cells for the different samples (healthy kidney, tumor, pre-REP TIL and REP TIL).&lt;/p&gt;
Phase 2 Study of Aficamten in Patients With Obstructive Hypertrophic Cardiomyopathy (2023)

Aficamten resulted in substantial reductions in LVOT gradients with most patients experiencing improvement in biomarkers and symptoms. These results highlight the potential of sarcomere-targeted therapy for treatment of oHCM.
Parthenocarpy in Summer Squash (1999)

Summer squash ( Cucurbita pepo L . ) cultivars were compared for ability to set parthenocarpic fruit. Some cultivars set no parthenocarpic fruit and others varied in the amount of fruit set when not pollinated. The degree of parthenocarpy varied with season, but the relative ranking of cultivars for parthenocarpy was generally similar. Cultivars with the best parthenocarpic fruit set were of the dark green, zucchini type, but some cultivars of other fruit types also set parthenocarpic fruit. A summer squash cultivar was developed that combines a high rate of natural parthenocarpy with multiple disease resistance. Yield of summer squash plants grown under row covers that excluded pollinating insects was as much as 83% of that of insect-pollinated plants in the open.