gebhart/patrepeval huggingface dataset:
Molecular evidence of N-methyl-D-aspartate receptor hypofunction in schizophrenia (2012)

Blockade of N-methyl-D-aspartate receptors (NMDARs) produces behavior in healthy people that is similar to the psychotic symptoms and cognitive deficits of schizophrenia and can exacerbate symptoms in people with schizophrenia. However, an endogenous brain disruption of NMDARs has not been clearly established in schizophrenia. We measured mRNA transcripts for five NMDAR subunit mRNAs and protein for the NR1 subunit in the dorsolateral prefrontal cortex (DLPFC) of schizophrenia and control (n=74) brains. Five NMDAR single-nucleotide polymorphisms (SNPs) previously associated with schizophrenia were tested for association with NMDAR mRNAs in postmortem brain and for association with cognitive ability in an antemortem cohort of 101 healthy controls and 48 people with schizophrenia. The NR1 subunit (mRNA and protein) and NR2C mRNA were decreased in postmortem brain from people with schizophrenia (P=0.004, P=0.01 and P=0.01, respectively). In the antemortem cohort, the minor allele of NR2B rs1805502 (T5988C) was associated with significantly lower reasoning ability in schizophrenia. In the postmortem brain, the NR2B rs1805502 (T5988C) C allele was associated with reduced expression of NR1 mRNA and protein in schizophrenia. Reduction in NR1 and NR2C in the DLPFC of people with schizophrenia may lead to altered NMDAR stoichiometry and provides compelling evidence for an endogenous NMDAR deficit in schizophrenia. Genetic variation in the NR2B gene predicts reduced levels of the obligatory NR1 subunit, suggesting a novel mechanism by which the NR2B SNP may negatively influence other NMDAR subunit expression and reasoning ability in schizophrenia.
Genistein Nanoparticles Protect Mouse Hematopoietic System and Prevent Proinflammatory Factors after Gamma Irradiation (2013)

Previous studies demonstrated that genistein protects mice from radiation-induced bone marrow failure. To overcome genistein's extremely low water solubility, a nanoparticle suspension of genistein has been formulated for more rapid dissolution. In the current study, we evaluated the radioprotective effects of a nanoparticle formulation of genistein on survival and hematopoietic recovery in mice exposed to total-body gamma irradiation. A single intramuscular injection of a saline-based genistein nanosuspension (150 mg/kg) administered to CD2F1 mice 24 h before 9.25 Gy (60)Co radiation exposure resulted in a 30-day survival rate of 95% compared to 25% in vehicle-treated animals. In mice irradiated at 7 Gy, the genistein nanosuspension increased mouse bone marrow cellularity from approximately 2.9% (vehicle treated) to 28.3% on day 7 postirradiation. Flow cytometry analysis demonstrated decreased radiation-induced hematopoietic stem and progenitor cell (HSPC, Lineage(-)/cKit(+)) death from 77.0% (vehicle) to 43.9% (genistein nanosuspension) with a significant recovery of clonogenicity 7 days after irradiation. The genistein nanosuspension also attenuated the radiation-induced elevation of proinflammatory factors interleukin 1 beta (IL-1β), IL-6 and cyclooxygenase-2 (COX-2) in mouse bone marrow and spleen, which may contribute to protecting HSPCs.
Asthma and Its Association with Cardiovascular Disease in the Elderly (1996)

Cardiovascular disease (CVD) is more prevalent in elderly than in middle-aged patients. Symptoms such as intermittent wheezing with dyspnea may then be due to either CVD or asthma. The objective of this study was to determine the prevalence and correlates of asthma in the elderly and their associations with CVD and CVD risk factors. A community sample of 5201 elderly persons from the Cardiovascular Health Study was asked if they had a physician diagnosis of asthma, and multiple cardiovascular risk and disease variables were measured. Six percent of the participants (309) recalled a history of asthma, and half of these were never smokers. Thirty percent of those with asthma were currently taking a bronchodilator, 14% inhaled steroids, and 10% oral prednisone. Men and women with asthma who were cigarette smokers were more likely to report a concurrent diagnosis of congestive heart failure than smokers without asthma (p = .04). However, when we determined the independent CVD correlates of asthma in this cohort, controlling for smoking status, age, gender, and diagnoses of chronic bronchitis and emphysema, only higher levels of high-density lipoprotein cholesterol (HDL-C) and higher plasma fibrinogen levels were significantly associated with asthma. It was concluded that asthma is as prevalent in the elderly as in middle-aged persons and is associated with higher HDL-C and higher fibrinogen levels, but not with prevalent cardiovascular disease.
Putting the squeeze on test sequences (2002)

Dynamic test sequence compaction is an effective means of reducing test application time and often results in higher fault coverages and reduced test generation time as well. A new algorithm for dynamic test sequence compaction is presented that uses genetic techniques to evolve test sequences. Test sequences provided by a test generator and previously evolved sequences already included in the test set are used as seeds in the genetic population. Significant improvements in test set size, fault coverage, and test generation time have been obtained over previous approaches.
Compression bandaging (2001)

Compression therapy is an important element to the treatment venous leg ulcers. Mary Eagle discusses the factors to be considered when applying compression bandage therapy
Measuring waves and currents with an upward-looking ADCP (1999)

Routine monitoring of waves and currents in the nearshore region is of great interest both scientifically and to the general public because of their role in coastline erosion and their impact on recreational activities. Historically, the technology for measuring these quantities has been distinct, requiring separate instrumentation for each. In this contribution the authors show that it is possible in shallow water to estimate both wave height and direction from a conventional bottom-mounted, upward-looking acoustic Doppler current profiler. Height and direction spectra compare well with a co-located array of pressure gages.
Modeling protein loops using a ϕi+1, Ψi dimer database (1995)

We present an automated method for modeling backbones of protein loops. The method samples a database of phi i + 1 and psi i angles constructed from a nonredundant version of the Protein Data Bank (PDB). The dihedral angles phi i + 1 and psi i completely define the backbone conformation of a dimer when standard bond lengths, bond angles, and a trans planar peptide configuration are used. For the 400 possible dimers resulting from 20 natural amino acids, a list of allowed phi i + 1, psi i pairs for each dimer is created by pooling all such pairs from the loop segments of each protein in the nonredundant version of the PDB. Starting from the N-terminus of the loop sequence, conformations are generated by assigning randomly selected pairs of phi i + 1, psi i for each dimer from the respective pool using standard bond lengths, bond angles, and a trans peptide configuration. We use this database to simulate protein loops of lengths varying from 5 to 11 amino acids in five proteins of known three-dimensional structures. Typically, 10,000-50,000 models are simulated for each protein loop and are evaluated for stereochemical consistency. Depending on the length and sequence of a given loop, 50-80% of the models generated have no stereochemical strain in the backbone atoms. We demonstrate that, when simulated loops are extended to include flanking residues from homologous segments, only very few loops from an ensemble of sterically allowed conformations orient the flanking segments consistent with the protein topology. The presence of near-native backbone conformations for loops from five different proteins suggests the completeness of the dimeric database for use in modeling loops of homologous proteins. Here, we take advantage of this observation to design a method that filters near-native loop conformations from an ensemble of sterically allowed conformations. We demonstrate that our method eliminates the need for a loop-closure algorithm and hence allows for the use of topological constraints of the homologous proteins or disulfide constraints to filter near-native loop conformations.
Sharing dictionaries among MT users by common formats and social filtering framework. (1999)

MT users have to build user in order to obtain high-quality translation results. However, building dictionaries needs time and labor. In order to meet the speed of the information flow in the global network society, we need to have common formats for sharing dictionaries among different MT systems, and a new way of dictionary authorization, that is social filtering.
Patterning hydroxyapatite biocoating by electrophoretic deposition (2003)

Patterned bioceramic coatings may find potential applications in orthopedic implants and biosensors. In this study, various hydroxyapatite (HA) patterns were created on silicon and titanium substrates. Electrophoretic deposition technique was used together with surface patterning of the cathode specimen. When gold/palladium patterns (hexagons, spherical dots, etc.) were created on the cathode surface, HA colloidal particles in ethanol would preferentially deposit on the gold-coated area and form patterns. When silicon, instead of gold, was evaporated onto a conducting cathode surface, HA mainly deposited on the exposed area of the substrate. Detailed mechanisms for forming HA patterns may involve local concentration of the electric field when a second metal is patterned on the cathode. The difference in electric field across the two metals on the cathode also enhances HA patterning through an electrohydrodynamic process. This study demonstrated the possibility and flexibility of electrophoretic deposition in patterning charged particles onto a substrate.
Solvolytic behavior of 7,7-dimethoxybicyclo[2.2.1]hept-2-yl tosylates (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolvolytic behavior of 7,7-dimethoxybicyclo[2.2.1]hept-2-yl tosylatesPaul G. Gassman, James L. Marshall, and James G. MacmillanCite this: J. Am. Chem. Soc. 1973, 95, 19, 6319–6326Publication Date (Print):September 1, 1973Publication History Published online1 May 2002Published inissue 1 September 1973https://pubs.acs.org/doi/10.1021/ja00800a027https://doi.org/10.1021/ja00800a027research-articleACS PublicationsRequest reuse permissionsArticle Views54Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Geographic web search based on positioning expressions (2005)

In this paper, we explore the use of natural language expressions to perform geographic searches on the Web, without resorting to geocoded data. Such expressions denote the positioning of a subject with respect to a landmark --- a valuable source of geographical context embedded in the unstructured text of Web documents. Our approach leads to novel query expansion techniques that can be explored by virtually any keyword--based search engine.
Pre-Impact Fall Detection: Optimal Sensor Positioning Based on a Machine Learning Paradigm (2014)

The aim of this study was to identify the best subset of body segments that provides for a rapid and reliable detection of the transition from steady walking to a slipping event. Fifteen healthy young subjects managed unexpected perturbations during walking. Whole-body 3D kinematics was recorded and a machine learning algorithm was developed to detect perturbation events. In particular, the linear acceleration of all the body segments was parsed by Independent Component Analysis and a Neural Network was used to classify walking from unexpected perturbations. The Mean Detection Time (MDT) was 351±123 ms with an Accuracy of 95.4%. The procedure was repeated with data related to different subsets of all body segments whose variability appeared strongly influenced by the perturbation-induced dynamic modifications. Accordingly, feet and hands accounted for most data information and the performance of the algorithm were slightly reduced using their combination. Results support the hypothesis that, in the framework of the proposed approach, the information conveyed by all the body segments is redundant to achieve effective fall detection, and suitable performance can be obtained by simply observing the kinematics of upper and lower distal extremities. Future studies are required to assess the extent to which such results can be reproduced in older adults and in different experimental conditions.
Microdegasser for HPLC Devices (2000)

Abstract The market of chemical analysis calls for more sensitive devices which are able to analyze very small sample volumes of only a few nanoliters in a very short time. Therefore, devices are required, which contain components with microscopic dimensions. Such micro devices can be fabricated with the AMANDA process. This paper describes a microdegasser for high performance liquid chromatography (HPLC), which was developed in a cooperation of Agilent Technologies, Forschungszentrum Karlsruhe (Karlsruhe Research Center), and STEAG microParts and is manufactured now by STEAG microParts. The microdegasser is one of the components, which help the new generation of HPLC devices of Agilent Technologies to achieve their excellent market position.
Variation in Expression of Reference Genes across Life Stages of a Bee, Megachile rotundata (2021)

The alfalfa leafcutting bee, <i>Megachile rotundata</i> is widely used in the western United States as a pollinator for alfalfa seed production. Unfortunately, immatures experience high mortality in agriculturally managed populations. Quantified gene expression could be used to identify how this bee responds during different life stages to pathogens, environmental toxins, and other stresses, but stably expressed reference genes are needed to normalize transcription data. We evaluated twelve candidate genes for their transcription stability across different life stages, including during and after diapause. RPS18 and RPL8 were the two most stably expressed genes, followed by RPS5 and RPL27A. These genes were also very stable even during and after diapause, while the most variable genes being APN, PMIIM, NPC2, and Cr-PII had increased expression levels during larval growth and were also variable during and after diapause. The four reference genes we identified in <i>M. rotundata</i> may prove useful for transcriptomic studies in other bees as well, such as honey bees.
Metal toxicity and the respiratory tract (1990)

The type of lung disease caused by metal compounds depends on the nature of the offending agent, its physicochemical form, the dose, exposure conditions and host factors. The fumes or gaseous forms of several metals, e.g. cadmium (Cd), manganese (Mn), mercury (Hg), nickel carbonyl (Nl(CO)4, zinc chloride (ZnCl2), vanadium pentoxide (V2O5), may lead to acute chemical pneumonitis and pulmonary oedema or to acute tracheobronchitis. Metal fume fever, which may follow the inhalation of metal fumes e.g. zinc (Zn), copper (Cu) and many others, is a poorly understood influenza-like reaction, accompanied by an acute self-limiting neutrophil alveolitis. Chronic obstructive lung disease may result from occupational exposure to mineral dusts, including probably some metallic dusts, or from jobs involving the working of metal compounds, such as welding. Exposure to cadmium may lead to emphysema. Bronchial asthma may be caused by complex platinum salts, nickel, chromium or cobalt, presumably on the basis of allergic sensitization. The cause of asthma in aluminium workers is unknown. It is remarkable that asthma induced by nickel (Ni) or chromium (Cr) is apparently infrequent, considering their potency and frequent involvement as dermal sensitizers. Metallic dusts deposited in the lung may give rise to pulmonary fibrosis and functional impairment, depending on the fibrogenic potential of the agent and on poorly understood host factors. Inhalation of iron compounds causes siderosis, a pneumoconiosis with little or no fibrosis. Hard metal lung disease is a fibrosis characterized by desquamative and giant cell interstitial pneumonitis and is probably caused by cobalt, since a similar disease has been observed in workers exposed to cobalt in the absence of tungsten carbide. Chronic beryllium disease is a fibrosis with sarcoid-like epitheloid granulomas and is presumably due to a cell-mediated immune response to beryllium. Such a mechanism may be responsible for the pulmonary fibrosis occasionally found in subjects exposed to other metals e.g. aluminium (Al), titanium (Ti), rare earths. The proportion of lung cancer attributable to occupation is around 15%, with exposure to metals being frequently incriminated. Underground mining of e.g. uranium or iron is associated with a high incidence of lung cancer, as a result of exposure to radon. At least some forms of arsenic, chromium and nickel are well established lung carcinogens in humans. There is also evidence for increased lung cancer mortality in cadmium workers and in iron or steel workers.
Effect of gum tragacanth on rheological and physical properties of a flavored milk drink made with date syrup (2013)

Date syrup as a nutritional additive and safe alternative to added sugar is one of the best choices for milk flavoring. In this study, a flavored milk beverage was formulated using date syrup for flavoring the product and gum tragacanth to obtain an acceptable mouth feel. Steady shear and dynamic oscillatory rheological properties of the samples contained 3 concentrations (0, 0.1, 0.2, and 0.3%, wt/wt) of 2 types of gum tragacanth (Astragalus gossypinus and Astragalus rahensis) which at 3°C, were studied. Particle size distribution and colorimetric assays were determined by laser diffractometry and using reflection spectrometer, respectively. Sensory analysis was performed with 25 semitrained panelists, using a 5-point hedonic scale. The results showed that viscoelastic properties, flow behavior parameters, particle size, and color parameters (L*, a*, and b*, where L* represents lightness, a* represents the redness/greenness quality of the color, and b* represents the yellowness and blueness quality of the colors) were significantly affected by the concentration of the gum tragacanth and the severity of this effect was influenced by the type of gum. The use of appropriate type and concentration of gum tragacanth in date milk formulation can improve the texture and mouth feel by affecting on particle size and the flow behavior of this product.
How to Turn a GSM SIM into a Web Server (2000)

We describe the WebSIM, an approach that integrates GSM SIMs into the Internet. The underlying idea is to implement a Web Server inside a SIM, and to allow for transparent access to it from the Internet. The contribution of our approach is that a SIM, which is currently a security module (smart card) fitted in a GSM mobile phone, becomes also a personal security server in the Internet. Like any other server in the Internet, it speaks TCP/IP and processes HTTP requests, e.g. for accessing certain SIM services (e.g. authentication) via CGI scripts. The Internet connectivity of a SIM inside a mobile phone can be achieved by having a proxy host tunnel IP packets to the SIM over SMS.
Phonon-induced increase in the energy gap of superconducting films (1976)

We have observed large increases in the critical current of Josephson junctions under 10-GHz phonon excitation. Eliashberg has predicted that absorption of microwaves in a superconducting film will increase the energy gap by creating a nonthermal quasiparticle distribution. We modify this theory for phonon absorption and calculate the increase in the critical current of a Josephson junction corresponding to the increase in the energy gap. We obtain good agreement between our data and the modified Eliashberg theory. We conclude that absorption of phonons of energy $\ensuremath{\hbar}\ensuremath{\omega}&lt;2\ensuremath{\Delta}(T)$ increases the superconducting energy gap.
Experimental study of elastica vibration (1989)

http://deepblue.lib.umich.edu/bitstream/2027.42/5272/5/bac3593.0001.001.pdf
A human vision system model for objective picture quality measurements (1997)

It is often useful to know the perceptual impact of distortions introduced at critical points in the production, distribution and display of video. Direct measurement using human observers is possible for some applications, but this is a time consuming operation that must be performed under carefully controlled conditions. A faster and more easily standardized approach is to use a vision model that provides accurate estimates of the visibility of differences between original and distorted image sequences. A model that fulfils this need is the Sarnoff just-noticeable difference (JND) model. This model is based on known physiological and psychophysical principles of human visual discrimination performance, rather than on particular classes of image distortions, and is therefore more robust across the often unpredictable range of distortions that can occur in modern digital video. The operation and general structure of the JND model are described, and its performance in a range of video applications is discussed.
Strawberry Fields: A Software Platform for Photonic Quantum Computing (2019)

We introduce Strawberry Fields, an open-source quantum programming architecture for light-based quantum computers, and detail its key features. Built in Python, Strawberry Fields is a full-stack library for design, simulation, optimization, and quantum machine learning of continuous-variable circuits. The platform consists of three main components: (i) an API for quantum programming based on an easy-to-use language named Blackbird; (ii) a suite of three virtual quantum computer backends, built in NumPy and TensorFlow, each targeting specialized uses; and (iii) an engine which can compile Blackbird programs on various backends, including the three built-in simulators, and - in the near future - photonic quantum information processors. The library also contains examples of several paradigmatic algorithms, including teleportation, (Gaussian) boson sampling, instantaneous quantum polynomial, Hamiltonian simulation, and variational quantum circuit optimization.