gebhart/patrepeval huggingface dataset:
Positive affect and the experience of meaning in life. (2006)

Six studies examined the role of positive affect (PA) in the experience of meaning in life (MIL). Study 1 showed strong relations between measures of mood, goal appraisals, and MIL. In multivariate analyses, PA was a stronger predictor of MIL than goal appraisals. In Study 2, the most consistent predictor of the experience of meaning in a day was the PA experienced that day. Later, global MIL was predicted by average daily PA, rather than average daily MIL. Study 3 demonstrated no prospective relations between measures of MIL and PA over 2 years. In Study 4, priming positive mood concepts enhanced MIL. In Study 5, manipulated positive mood enhanced ratings of MIL for those who were not given an attributional cue for their moods. In Study 6, PA was associated with a high level of distinction between meaningful and meaningless activities. Results indicate that positive moods may predispose individuals to feel that life is meaningful. In addition, positive moods may increase sensitivity to the meaning-relevance of a situation.
Improving the Effectiveness of Healthcare: Diagnosis-Centered Care Vs. Person-Centered Health Promotion, a Long Forgotten New Model (2022)

Performance of healthcare can be measured as its ability to restore and preserve health with acceptable costs for the society. Under the current prevalence of chronic disease, medical care (the major content of healthcare) underperforms in all key indicators: clinical effectiveness, benefit/risk ratio of interventions, cost/benefit ratio, and general population health. In Russia key performance indicators (KPI) of healthcare do not allow effective decision-making; a similar situation is seen worldwide: most KPIs are either focused on the process (not results) of medical care, or depend on efforts out of control of healthcare decision-makers. The key root factors limiting clinical effectiveness and cost-effectiveness of healthcare are reactive diagnosis-centered organizational model of care and the underlying biomedical paradigm, generally inadequate in chronic diseases. They make healthcare intervene too late, use less effective prevention and treatment instruments, and be in a state of resource scarcity. In Russia there is also a lack of interdisciplinary and interagency cooperation essential for health preservation and promotion. Performance of healthcare system in overcoming the chronic disease epidemic can be improved through supplementing the current 'reactive' organizational model with preventive person-centered model based on the biopsychosocial paradigm. Enabling patients for early lifestyle-based interventions, the core P4 medicine approach, should prevail in managing chronic disease. Communication and information technologies should allow fast scaling up of the best person-centered practices.
Heat diffusion related damping process in highly precise coarse-grained model for SWCNT's nonlinearity (2019)

Second sound and heat diffusion in single-walled carbon nanotubes (SWCNT) is well-known phenomena which is related to the high thermal conductivity of this material. In this paper, we have shown that the heat diffusion along the tube axis affects the macroscopic motion of SWCNT and adapting this phenomena to coarse-grained model can improve the precision of the coarse-grained molecular dynamics (CGMD) exceptionally. The nonlinear macroscopic motion of SWCNT in the free thermal vibration condition in adiabatic environment is demonstrated in the most simplified version of CG modeling as maintaining finite temperature and total energy with suggested dissipation process derived from internal heat diffusion. The internal heat diffusion related to the cross correlated momentum from different potential energy functions is considered, and it can reproduce the nonlinear dynamic nature of SWCNTs without external thermostatting in CG model. Memory effect and thermostat with random noise distribution are not included, and the effect of heat diffusion on memory effect is reviewed through Mori-Zwanzig formalism. This diffusion shows perfect syncronization of the motion between that of CGMD and MD simulation, which is started with initial conditions from the molecular dynamics (MD) simulation. The heat diffusion related to this process has shown the same dispersive characteristics to second wave in SWCNT. This replication with good precision indicates that the internal heat diffusion process is the essential cause of the nonlinearity of the tube. The nonlinear dynamic characteristics from the various scale of simple beads systems are examined with expanding its time step and node length simultaneously.
Biomembrane mimics and their roles in anti-bacterial drug discovery (2017)

Cell membrane is at the frontline of the battle between pathogenic microbe and host. A thorough understanding of bacterial membrane is fundamental to tackle infection disease. Membrane mimetic provides a powerful tool for mechanistic interrogation of drug-membrane interaction. Herein, we summarized major features of bacterial and mammalian cell in context of antibacterial therapy. Much details were given to model membranes and their application in mechanistic studies. Current challenge in antibacterial therapy and perspective of membrane mimics in antibacterial drug discovery were also provided.
Indium mediated isoprenylation of carbonyl compounds with 2-bromomethyl-1,3-butadiene: a short synthesis of (±)-ipsenol (2003)

Isoprenylation of aldehydes and ketones was directly performed by selective indium insertion on a mixture of 2-bromomethyl-1,3-butadiene and its vinylic isomers in good yields. A short synthesis of (±)-ipsenol, an aggregation pheromone of the Ips paraconfusus bark beetle, demonstrates the utility of this method in organic synthesis.
Use of Quantitative TaqMan Real-Time PCR to Track the Time-Dependent Distribution of Gene Transfer Vectors in Vivo (2000)

To assess the biodistribution and pharmacokinetics of gene transfer vectors, real-time PCR with fluorescent TaqMan chemistry was used to quantify tissue levels of adenovirus gene transfer vectors (Ad) following myocardial administration. After optimizing the detection of the genome of Ad vectors expressing human vascular endothelial growth factor (Ad(GV)VEGF121.10) and Escherichia coli cytosine deaminase (Ad(GV)CD.10), a comparison was made of intramyocardial injection versus intracoronary delivery to the left ventricle of the pig. One hour post-intramyocardial administration, the left ventricular Ad genome level was 6.2 copies per cellular genome, 26-fold higher than the level of 0.24 copies per cellular genome following intracoronary administration. Relative to the vector levels after 1 h, the amount dropped 14- and 5.5-fold by 24 h following intramyocardial and intracoronary administration, respectively. Interestingly, the vector that escaped the left ventricle after intracoronary or intramyocardial administration to pigs was found primarily within the lung, an observation in marked variance to the biodistribution of Ad vector in rodents. In this regard, after intravenous injection to the pig, 90% of the recovered vector was found in the lung, and even after intrahepatic portal vein injection, 55% of the recovered vector was in the lung. These data have important implications regarding the use of experimental animals for safety studies on administration of Ad to humans.
The Role of Calcium/Calmodulin-Dependent Protein Kinase Cascade on MIP-1α Gene Expression in ATL Cells. (2006)

Abstract Adult T-cell leukemia (ATL) is a mature CD4+ T-cell malignancy caused by infection with human T-lymphotrophic virus (HTLV-1) and is associated with a marked hypercalcemia on many patients. Recently, it is proposed that Macrophage inflammatory protein-1α (MIP-1α) is the clinical hallmark of hypercalcemia in ATL, but the regulation of MIP-1α secretion has not been clarified yet. In this study, we examined the effect of calcium on the MIP-1α secretion and cell proliferation of ATL cells, and also the role of the Ca2+/calmodulin (CaM)-dependent protein kinase (CaM-K) cascade in transcriptional activation of MIP-1α. The addition of calcium nitrate to the medium enhanced the secretion of MIP-1α by ATL cell lines (ATN, MT-2, OKM-2T) and the proliferation in a dose dependent manner. The maximum response of MIP-1α secretion was induced at 10.42mM calcium in OKM-2T cells. CaM-KK selective inhibitor STO-609 inhibited the calcium dependent secretion of MIP-1α and proliferation of ATL cell lines. We investigated the effects of CaM-KK/CaM-KIV signaling pathway on MIP-1α promoter activity in OKM-2T. The transfection of CaM-KIV stimulated the MIP-1α promoter activity and the upstream kinase, CaM-KK enhanced the stimulatory effect of CaM-KIV on its activity. Furthermore, mutation of the cAMP response element (CRE) within the MIP-1α promoter significantly reduced the effect of CaM-KIV and calcium, and it wasn’t less enhanced by the addition of calcium nitrate to the medium than the wild type. Our studies have indicated that hypercalcemia enhances MIP-1α secretion and the cell growth in ATL cells, and these mechanisms require the CaM-KK/CaM-KIV cascade. These findings raise the possibility that the inhibitory of CaM-KK/CaM-KIV cascade may be of therapeutic value for ATL.
Current developments in hernia repair; meshes, adhesives, and tacking. (2010)

Open and laparoscopic hernia surgery continues to evolve with new products allowing surgeons multiple choices in treating their patients. The evolution towards tension-free techniques in dealing with hernias requires that today's surgeons know the options available in meshes as well as fixation methods in order to have the best outcomes. In recent years, there has been a rapid expansion in the number of meshes available. Currently, there are numerous uncoated, coated, and biologic meshes in production that can be used in hernia repair. This paper will focus on the latest developments in coated meshes that allow for intra-abdominal placement as well as the different types of biologic meshes and their typical uses. Tacking devices for laparoscopic hernia repair now come in titanium as well as absorbable devices. AbsorbaTack™ (Covidien, Norwalk, CT) and Sorbafix™ (Davol, Warwick, RI) are two of the newest absorbable tacking devices thought to possibly benefit patients with decreased pain and long-term complications as compared with their titanium counterparts. Adhesives continue to be used more and more for hernia repair, especially in inguinal and paraesophageal hernia repairs. Tissucol™/Tisseel™ (Baxter, Deerfield, IL) and Evicel™ (Ethicon, Somerville, NJ) are two types of fibrin glues that are available for use in hernia repair. Practitioners using these biologic adhesives think there is less pain compared with tacking.
Ultrasonic nondestructive testing of scattering media using the decomposition of the time-reversal operator (2002)

In ultrasonic nondestructive testing, the iterative time-reversal process is an adaptive technique that can be used to detect flaws in complex samples with a large array of transducers. The decomposition of the time-reversal operator (DORT) method is a detection technique that is derived from the mathematical analysis of the iterative time-reversal process. Contrary to time-reversal techniques, the DORT method does not require programmable generators, and it allows the simultaneous detection and separation of several defects. In this paper, the method is applied to a Ti6-4 titanium cylindrical sample to separate the echo of a defect from the speckle due to microstructure contribution. The grain structure of this titanium alloy makes detection very difficult and, for large depths, conventional techniques do not allow the detection of small flaws with a satisfactory signal-to-noise ratio. The efficiency of the DORT method to detect a flat bottom hole with a diameter of 0.4 mm located at a depth of 140 mm in a titanium alloy sample is shown.
Fields of Spiral Conformal Arrays Using Huggins Scanning and a Conformal Feed Network for a Circular Array. (1974)

Abstract : An array of fan-shaped segments arranged in a spiral-like manner is described. The fan-shaped segment, which may consist of a board of stripline or microstrip, contains several radiating elements phased by the Huggins or I.F. method. The fields produced by single segments are calculated and the characteristics of the radiated beams are given. Quantitative expressions for the field produced by spiral arrays are derived and examples of field patterns and beam properties are given. A method is presented for coupling the outputs of an array of segments to feed a circular array to obtain conformal scanning. When used in this latter manner, the dimensions of an array of segments can be greatly reduced.
PREPARATION AND STRUCTURAL STUDIES OF A NUMBER OF HETEROCYCLIC PHOSPHORANES (1985)

Abstract A series of monocyclic five-membered ring containing trivalent phosphorus compounds with oxygen, nitrogen and sulfur bonded to phosphorus, in various combinations has been allowed to react with trifluoroethyl and 1,1,1,3,3,3-hexafluoroisopropyl benzenesulfenates. In some cases, pentacoordinated phosphorus compounds resulted. These materials have been studied by various NMR techniques. The same trivalent phosphorus compounds were allowed to react with 3,4-(bistrifluoromethyl)1,2,dithiete. In some cases phosphoranes were formed and they were also studied by NMR.
[Potential cardiotonic agents. 6. Synthesis and cardiovascular properties of 5-(4-pyridinyl)-, 6-methyl-5-(4-pyridinyl)- and 6-methyl-5-phenyl-substituted 3-cyano-2-oxaalkyoxy-pyridines]. (1990)

The headline compounds were prepared by the reaction of 2-chloropyridines 1-3 with the appropriate alcohols in presence of potassium hydroxide and the sodium alkoxides, respectively. Especially some of the 3-cyano-2-hydroxyalkoxy-5-(4-pyridinyl)pyridines showed remarkable positive inotropic potency and, additionally, a vasodilator activity. In spontaneously beating isolated guinea pig atria they had a greater activity than amrinone.
Biocompatibility of a new PD solution for Japan, Reguneal™, measured as in vitro proliferation of fibroblasts (2018)

Our study suggests that Reguneal™ is a biocompatible PDF. The results of our study also highlight that dextrose and GDPs are important for biocompatibility, but alone are not a complete surrogate. The results of our study need to be confirmed in other tissue culture models, and should lead to further research on determinants of biocompatibility and the effect of such PDFs on clinical outcomes.
Iterative Receiver Architectures for Downlink MIMO CDMA Evolution (2007)

International audience
Serum Protein Absorption on Silk Fibroin Fibers and Films: Surface Opsonization and Binding Strength (2002)

Fibroin, the core of the silk filament protein, has been proposed as a biomaterial for different biomedical applications since it can be engineered as a thread, fabric or film. Infrared spectroscopy suggests that the dissolution of the fibroin filaments and subsequent casting of the fibroin solution into films followed by treatment with methanol alters the protein structure leading to an increase in amorphous domains. The adsorption ofserum proteins on fabrics and films showed different hydrophobic binding strengths for the two materials with the protein binding being greatest for the more hydrophobic fibroin fibers. Differences between the materials were also observed in the adsorption of key immunoproteins. Although the C3 fragment of the complement system was adsorbed on both the surfaces, it appeared to be activated preferentially on the fibroin films and not on the fibroin fibers, whereas the Bb and C1q factors were only significantly present on the fibroin fabric. IgG appeared to be adsorbed, although to different extents, on both types of fibroin substrates. These results suggest that the biocompatibility of the silk fibroin may be affected by changes in protein structure induced by processing the material.
Comparison of active phased array antennas for communication satellite applications (1988)

The overall performances of a Direct Radiating Array and of a Near Field Multibeam Antenna, together with their associated circuitry, are compared in the case of a Ku-band communication satellite covering Western Europe. For both configurations an active antenna solution with a multiple beam type coverage is assumed.
Assessment of long-term safety and efficacy of etanercept in a 5-year extension study in patients with rheumatoid arthritis. (2011)

ETN maintained a favourable safety profile and consistent efficacy throughout the 5-year study duration.
Demand Side Management in a highly decentralized energy future (2010)

Demand Side Management (DSM), first referred in the US in the late 1970s, is based on the purpose of the planning, implementation and monitoring, of the activities of electric utilities to influence customer usage of electricity that will result in desired changes in the load shape experienced by the distribution system, i.e. changes in the time pattern and magnitude of the network load. The objective of DSM activities is to influence the load-shape and make a reduction of the total load demand of the distribution system during peak periods in order to maintain the integrity of the network and stability of the whole system. The significance of successful planning and implementation of DSM requires balancing the relationship between the utilities and the customer requirements. The network load shape can be altered by means of six broad categories: peak clipping, valley filling, load shifting, strategic conservation, strategic load growth, and flexible load shape. Increasing energy efficiency, application of peak load shifting in controllable environment, installation of decentralized energy sources and smart grid components, and implementation of supporting policies are currently under serious consideration and trial and can be viewed as extensions of the traditional approaches to DSM. This paper refers to the literature review on basic DSM principles, operational issues, and economic perspectives in the LV networks.
Detection of Older People at Increased Risk of Adverse Health Outcomes After an Emergency Visit: The ISAR Screening Tool (1999)

The ISAR is a short self-report questionnaire that can quickly identify older patients in the ED at increased risk of several adverse health outcomes and those with current disability.
On Regression in Extreme Regions (2023)

We establish a statistical learning theoretical framework aimed at extrapolation, or out-of-domain generalization, on the unobserved tails of covariates in continuous regression problems. Our strategy involves performing statistical regression on a subsample of observations with continuous labels that are the furthest away from the origin, focusing specifically on their angular components. The underlying assumptions of our approach are grounded in the theory of multivariate regular variation, a cornerstone of extreme value theory. We address the stylized problem of nonparametric least squares regression with predictors chosen from a Vapnik-Chervonenkis class. This work contributes to a broader initiative to develop statistical learning theoretical foundations for supervised learning strategies that enhance performance on the supposedly heavy tails of covariates. Previous efforts in this area have focused exclusively on binary classification on extreme covariates. Although the continuous target setting necessitates different techniques and regularity assumptions, our main results echo findings from earlier studies. We quantify the predictive performance on tail regions in terms of excess risk, presenting it as a finite sample risk bound with a clear bias-variance decomposition. Numerical experiments with simulated and real data illustrate our theoretical findings.
Confocal filtering in cathodoluminescence microscopy of nanostructures (2014)

Cathodoluminescence (CL) microscopy allows optical characterization of nanostructures at high spatial resolution. At the nanoscale, a main challenge of the technique is related to the background CL generated within the sample substrate. Here, we implement confocal detection of the CL signal to minimize the background contribution to the measurement. Nano-phosphors were used as point sources to evaluate the filtering capabilities of our confocal CL system, obtaining an axial intensity profile with 2.7 μm full width at half maximum for the central peak, in good correspondence with theoretical expectations. Considering the electron interaction volume, we found that the confocal filter becomes effective for electron energies above 20 keV, when using a 25 μm pinhole (0.86 Airy units). To illustrate our approach, we present confocal CL imaging of gold nanowires and triangular shaped plates deposited on an indium-tin oxide covered glass substrate, comparing the images with those obtained in standard unfiltered CL detection. The results show that confocal CL microscopy is a valuable tool for the investigation of nanostructures on highly cathodoluminescent substrates, widely used in biological and optical applications.
Reducing Computational Costs in Sentiment Analysis: Tensorized Recurrent Networks vs. Recurrent Networks (2023)

Anticipating audience reaction towards a certain text is integral to several facets of society ranging from politics, research, and commercial industries. Sentiment analysis (SA) is a useful natural language processing (NLP) technique that utilizes lexical/statistical and deep learning methods to determine whether different-sized texts exhibit positive, negative, or neutral emotions. Recurrent networks are widely used in machine-learning communities for problems with sequential data. However, a drawback of models based on Long-Short Term Memory networks and Gated Recurrent Units is the significantly high number of parameters, and thus, such models are computationally expensive. This drawback is even more significant when the available data are limited. Also, such models require significant over-parameterization and regularization to achieve optimal performance. Tensorized models represent a potential solution. In this paper, we classify the sentiment of some social media posts. We compare traditional recurrent models with their tensorized version, and we show that with the tensorized models, we reach comparable performances with respect to the traditional models while using fewer resources for the training.
On the fragmentation of stereoisomeric substituted cyclohexylamines under electron impact. Comparison with corresponding alcohols and ethers (1978)

Abstract The stereospecific elimination of H 2 O and CH 3 OH from substituted cyclohexanols and their methyl ethers upon electron impact is not reproduced in the corresponding amines. Ring cleavage α to the amino group is responsible for the non‐stereospecific formation of the most abundant fragments in the amines.