gebhart/patrepeval huggingface dataset:
Structure of sodium nitrilotriacetatocopper(II) monohydrate (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure of sodium nitrilotriacetatocopper(II) monohydrateSimon H. WhitlowCite this: Inorg. Chem. 1973, 12, 10, 2286–2289Publication Date (Print):October 1, 1973Publication History Published online1 May 2002Published inissue 1 October 1973https://pubs.acs.org/doi/10.1021/ic50128a015https://doi.org/10.1021/ic50128a015research-articleACS PublicationsRequest reuse permissionsArticle Views143Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Central nervous system diseases and the role of the blood-brain barrier in their treatment (2013)

Introduction The human central nervous system (CNS) is the most complex organ. It determines our most unique human function, namely, consciousness. Its activity underlies all aspects of our behavior from basic requirements such as breathing to supporting our thoughts and feelings [1]. Brain diseases can result directly from intrinsic dysfunction of
Fischer Indole Synthesis with Organozinc Reagents (2010)

Primary and secondary alkylzinc reagents add to various aryldiazonium salts leading to polyfunctional indoles by means of a [3,3]-sigmatropic shift and subsequent aromatization.
Deactivation of Automobile Exhaust Control Catalyst (1970)

A catalytic converter for controlling automobile exhaust emissions was evaluated in California in 1964. Results from this fleet test and subsequent analysis of the spent catalyst are presented. Statistical analysis of dynamometer test results indicates a strong effect of tetraethyl lead content of the gasoline on activity decline. Analysis of spent catalyst revealed that both surface area and accumulated lead are major factors in activity decline. Above 100 m2/g a further increase in surface area at constant lead level resulted in a decline in activity.
Laboratory evaluation of in situ geotechnical torsional cylindrical impulse shear test for earthquake resistant design (1993)

Abstract We discuss laboratory tests of a prototype in situ geotechnical torsional cylindrical impulse shear testing system. The purpose of the torsional cylindrical impulse shear test is to provide estimates, for soil deposits, of in situ undegraded nonlinear inelastic shear stress versus strain characteristics. The laboratory tests were conducted on a large sample of medium dense Ottawa sand. Undegraded nonlinear inelastic shear stress versus strain characteristics estimated for the sand based on results from these tests are consistent with corresponding published estimates based on results from laboratory tests (resonant column and cyclic triaxial tests) and field array studies. Shear strains of up to about 0.1% and an 80% reduction in shearing stiffness were inferred to have developed. Test results were judged to be sensitive to undergraded soil characteristics (low strain shear modulus and shape of shear stress versus strain curve) and repeatable. Also, we judged that penetration-induced disturbances to the test sand were not excessive. Major difficulties or limitations of the testing system were not encountered during the laboratory tests. We concluded that the torsional cylindrical impulse shear test is promising for field use.
Digital rights management, copyright, and Napster (2001)

Digital Rights Management technologies in the field of copyright protection should meet four objectives: • give consumers new freedom to enjoy music and other forms of content; • give copyright owners and other value chain participants the means to manage and protect their rights in published works; • implement elements of law, such as copyright exceptions, that ensure that rights are managed in accordance with the public interest; • provide users with the means to manage their legitimate personal rights and interests.We sketch how these goals can be achieved with current technology for peer-to-peer Digital Rights Management (DRM). This technology can ensure the neutrality, security, commercial reliability, and trusted interoperability of applications and services used to protect and manage rights in all forms of information, including creative works protected by copyright. The rapidly evolving area of digital commerce in information requires a framework of commercial trust comparable in scope, and at least as reliable, as the systems of trust that underpin commerce in the physical world.
ASSOCIATION OF INJURIES AND AEROBIC FITNESS IN MEN AND WOMEN PARTICIPATING IN US ARMY BASIC TRAINING (1999)

308 Previous research has demonstrated that during US Army basic training, slower maximal effort two-mile run times are associated with higher injury risk. However, whether injury risk is related to aerobic capacity or other aspects of running (e.g., pacing, motivation, lactate threshold) is not clear. We examined associations between injuries, peak VO2 and running performance in 162 men and 148 women participating in gender-integrated US Army basic training. Before the 8-week basic training cycle, subjects performed a maximal effort 2-mile run for time and completed a peak VO2 test (continuous treadmill running protocol). Lower extremity musculoskeletal injuries with one or more days of limited duty were obtained by screening subject medical records during training. Subjects were divided into gender-specific quartiles based on their performance on the run or peak VO2 test; injury risk in each quartile (Q) was determined. The percentage of trainees injured in each Q (higher Q indicates faster run or higher peak VO2), relative risk (RR), and p-value (Mantel-Haenszel chi-square for trend) were: (Table)TableThese data suggest that the proportion of subjects injured declines as initial aerobic fitness increases, regardless of whether aerobic fitness is measured with a two-mile run or peak VO2 test.
Subdiffusive wave transport and weak localization transition in three-dimensional stealthy hyperuniform disordered systems (2022)

The purpose of this work is to understand the fundamental connection between structural correlations and light localization in three-dimensional (3D) open scattering systems of finite size. We numerically investigate the transport of vector electromagnetic waves scattered by resonant electric dipoles spatially arranged in 3D space by stealthy hyperuniform disordered point patterns. Three-dimensional stealthy hyperuniform disordered systems are engineered with different structural correlation properties determined by their degree of stealthiness $\ensuremath{\chi}$. Such fine control of exotic states of amorphous matter enables the systematic design of optical media that interpolate in a tunable fashion between uncorrelated random structures and crystalline materials. By solving the electromagnetic multiple scattering problem using Green's matrix spectral method, we establish a transport phase diagram that demonstrates a distinctive transition from a diffusive to a weak localization regime beyond a critical scattering density that depends on $\ensuremath{\chi}$. The transition is characterized by studying the Thouless number and the spectral statistics of the scattering resonances. In particular, by tuning the $\ensuremath{\chi}$ parameter, we demonstrate large spectral gaps and suppressed subradiant proximity resonances, facilitating light localization. Moreover, consistently with previous studies, our results show a region of the transport phase diagram where the investigated scattering systems become transparent. Our work provides a systematic description of the transport and weak localization properties of light in stealthy hyperuniform structures and motivates the engineering of photonic systems with enhanced light-matter interactions for applications to both classical and quantum devices.
Transient analysis of heat loss in earth bermed structures (1980)

Passive solar structures commonly utilize earth bermed walls to enhance energy conservation in spite of the lack of well-validated guidelines capable of quantifying their expected thermal performance. In an effort to provide some added insight on the thermal response of earth bermed structures, a transient two-dimensional model sufficiently general to accommodate numerous earth sheltering configurations under variable boundary and soil conditions has been developed. This allows accelerated investigation of systems which, due to their thermal properties, are transient in nature with extremely long time constants. The present model considers time dependent soil properties, different types of below-grade structure configurations, and various types, thicknesses and locations of insulation. Heat loss and gain through the exterior building envelope versus location and time of year are given as functions of construction materials, insulation and soil geometry.
Effect of thymectomy and antilymphocyte serum on Mycobacterium leprae infection in mice (1975)

BALB/c mice thymectomized at 3 to 5 days of age were studied to determine if this procedure would result in enhanced susceptibility to infection with Mycobacterium leprae and, if so, whether or not administration of antilymphocyte serum would further increase this susceptibility. The plateau for growth in the footpads of intact mice occurred 4 months after inoculation, whereas in the thymectomized and thymetocomized plus antilymphocyte serum-treated groups the plateau occurred between months 11 and 12 after inoculation. Thymectomy resulted in at least a 10-fold increase in the number of M. leprae found in the footpads. Antilymphocyte serum did not appear to further enhance the M. leprae infection in the thymectomized mice. Although growth of M. leprae in the testes of both intact and thymectomized mice was erratic, the number of organisms reached a higher ceiling in the thymectomized groups. M. leprae harvested from all groups was passaged into intact mice at various intervals after inoculation to test for viability. Viable M. leprae were found at all intervals tested including 22 months after infection in the intact mice, suggesting that a chronic infection occurred that probably lasted during the entire life of the animals.
Utilization of Two Distinct Modes of Replication by a Hybrid Plasmid Constructed In Vitro from Separate Replicons (1974)

A hybrid plasmid, pSC134, that codes for two distinct sets of replication functions has been constructed in vitro by ligation of EcoRI endonuclease-cleaved pSC101 and Col E1 plasmid replicons, and has been introduced into Escherichia coli by transformation. The replication properties of the pSC134 plasmid in DNA polymerase I-defective mutants or in the presence of chloramphenicol indicate that this hybrid plasmid can utilize the functionally distinct modes of replication specified by both of its parent replicons.
Bombesin may stimulate proliferation of human pancreatic cancer cells through an autocrine pathway (1996)

Bombesin is trophic to normal pancreas and acinar cell adenocarcinoma, but its effects on ductal cell tumors are undetermined. The autocrine growth effects of bombesin on well-differentiated (HPAF, CD11) and poorly differentiated (CD18, PANC-1) human ductal pancreatic cancer cell lines were investigated. Receptor binding of labeled bombesin was measured in a whole-cell microplate assay. Bombesin production was measured by radioimmunoassay. Proliferative responses were quantified using the MTT assay. Messenger RNA for bombesin and its receptor were identified by primer extension analysis. A single class of high-affinity binding sites was detected on HPAF and CD18 cells. Similar affinities and high receptor densities were found on the 2 cell lines. Bombesin was secreted by all 4 cell lines during 24-hr culture in serum-free media, and its recovery was enhanced in the presence of protease inhibitors. Primer extension analysis demonstrated the presence of mRNA for both bombesin and its receptor in HPAF, CD18, CD11 and PANC-1 cells, even though no functional receptor was found in the latter 2 lines. Bombesin significantly stimulated the proliferation of HPAF and CD18 cells. This trophic effect was inhibited by the specific bombesin antagonist RC-3095. Bombesin may act as an autocrine growth factor in some human pancreatic cancer cell lines. Furthermore, other cell lines transcribe mRNA for bombesin receptors but have no functional bombesin receptors, suggesting a genetic or post-translational change in the receptor for these cells. Bombesin may be involved as a growth factor in the development of pancreatic ductal adenocarcinoma in humans. This possible autocrine growth pathway may provide an avenue for therapeutic intervention in this malignant disease.
Cooperative Area Coverage Reconnaissance Method for Multi-UAV System (2011)

Aiming to find a solution, the method of cooperative area coverage reconnaissance for Multi-UAV system is proposed by combining centralized preplanning with distributed partial online replanning. In the preplanning, grid disintegration is applied to divide the area to be reconnoitered into task sequence of nodes and fuzzy C-means clustering algorithm is applied to conduct space distribution of task nodes; the online partial replanning is that the left UAVs automatically complete the unfinished task of the failed UAV, using the membership matrix got by clustering algorithm as a unified standard, which ensures that so long as one UAV does not fail, the reconnaissance task can be normally carried on. The simulation results show that this method, simple yet with a high robustness, can effectively solve the problem of multi-UAV cooperative area coverage reconnaissance.
Biology of Subterranean Termites: Insights from Molecular Studies ofReticulitermesandCoptotermes (2008)

Molecular genetic techniques have made contributions to studies on subterranean termites at all levels of biological organization. Most of this work has focused on Reticulitermes and Coptotermes, two ecologically and economically important genera. DNA sequence data have significantly improved our understanding of the systematics and taxonomy of these genera. Techniques of molecular biology have provided important new insights into the process of caste differentiation. Population genetic markers, primarily microsatellites, have furthered our understanding of the life history, population biology, community ecology, and invasion biology of subterranean termites. Recent results on the behavioral ecology of subterranean termites reveal a picture different from long-held views, especially those concerning colony breeding structures and foraging ranges. As additional molecular tools and genomic resources become available, and as more subterranean termite researchers incorporate molecular techniques into their approaches, we can expect accelerating advances in all aspects of the biology of this group.
Figure S2 from A Convolutional Neural Network Uses Microscopic Images to Differentiate between Mouse and Human Cell Lines and Their Radioresistant Clones (2023)

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Increased radiative lifetime of rare earth-doped zinc oxyhalide tellurite glasses (1997)

We have investigated the structural and optical properties of rare earth-doped zinc tellurite glasses modified by the substitution of ZnF2. Raman and phonon sideband spectroscopies were employed to characterize changes in the glass structure as well as to probe vibrational behavior in the immediate vicinity of the rare earth ion. These measurements are combined with photoluminescence and optical absorption to monitor the effect of halide substitution upon the optical behavior of the rare earth dopant. A substantial increase in the intrinsic radiative lifetime of Nd3+ is observed with increasing halide concentration.
Myogenic regulatory protein expression in adult soft tissue sarcomas. A sensitive and specific marker of skeletal muscle differentiation. (1994)

Myogenic regulatory protein (MyoD1) is a DNA-binding nuclear protein that initiates myogenesis in mesenchymal stem cells. Its expression has proved a very sensitive marker of myogenic differentiation in malignant tumors of childhood. In this study, the reliability of MyoD1 expression as marker of skeletal muscle differentiation has been tested in 38 cases of adult-type sarcomas. Frozen sections were stained with the monoclonal antibody 5.8A (MAb 5.8A) developed against recombinant wild-type murine MyoD1. Routinely processed formalin-fixed sections from the same cases were reviewed and immunostained with a panel of antibodies commonly used to detect muscle differentiation: myoglobin, fast-myosin, desmin, muscle-specific actin, alpha-smooth muscle actin. Four cases positively stained with MAb 5.8A: three were high-grade spindle cell sarcomas, the fourth case was an alveolar soft-part sarcoma. Only tumors in which skeletal muscle histogenesis was inferred on the basis of histology and/or immunohistochemistry with conventional muscle markers stained positively for MAb 5.8A. All the other tumors tested, including leiomyosarcomas (11), liposarcomas, (10, including four dedifferentiated liposarcomas), fibrosarcomas (three), malignant fibrous histiocytomas (two), synovial sarcomas (two), and malignant peripheral nerve sheath tumors (two), were negative for MAb 5.8A. The high level of sensitivity and specificity of MyoD1 expression indicates the value of this marker in the diagnosis of soft tissue sarcomas.
Breast cancer cells are effectively purged from peripheral blood progenitor cells with an immunomagnetic technique. (1996)

Peripheral blood progenitor cells (PBPCs) are being used increasingly to provide hematopoietic support after intensive chemotherapy. However, many investigators have detected tumor cells contaminating PBPC collections. Methods that eliminate the tumor cells and spare the normal hematopoietic progenitor cells may improve the number of long-term, disease-free survivors after intensive chemotherapy. We developed an effective method using anti-breast cancer murine monoclonal antibodies (MoAbs) and immunomagnetic beads to eliminate a low percentage of breast cancer cells from PBPCs. We identified optimal anti-breast cancer MoAbs that react with membrane glycoproteins and conditions for selective removal of tumor cells. Using three anti-breast cancer MoAbs (260F9, 317G5, and 520C9) at 0.8 microgram/ml, a cell concentration of 2 x 10(8) cells/ml and a bead:total cell ratio of 0.75 beads:1 cell, we eliminated 3.3-4.8 (mean, 4.1) logs of tumor cells consistently from a model system with 1% breast cancer cells and 99% normal PBPCs. Similar levels of tumor cell elimination were obtained with three breast cancer cell lines. Colony-forming units were not affected adversely, with a mean recovery of 200% compared with the control. A clinical trial has begun that uses immunomagnetically purged, autologous bone marrow and PBPCs to support patients with metastatic breast cancer receiving high-dose chemotherapy.
Fetal DNA in Maternal Circulation of First-Trimester Spontaneous Abortions (2001)

In Brief Objective To establish whether fetal DNA can be identified in the maternal circulation in first-trimester spontaneous abortions. Methods Women with confirmed spontaneous abortions and no histories of previous pregnancy were recruited. Peripheral venous blood samples were obtained and DNA extracted. Real-time quantitative polymerase chain reaction was done using SRY and β-actin systems for calculating fetal and total DNA, respectively. Results Of 25 women, SRY-specific signals were detected in 11 indicating that the abortions were male. The remaining 14 were negative for the SRY gene. Women with positive results were of similar gestational age to those who were negative (mean 68.4 and 69.0 days). Fetal:total DNA ratio was calculated for positive samples and ranged from 15.8 to 360.1 × 10+3. Mean ratio was 99.4 × 10+3 and median was 67.5 × 10+3. Conclusion Fetal DNA is present in the maternal circulation of first-trimester spontaneous abortions. Fetal DNA is present in the maternal circulation of first-trimester spontaneous abortions.
Phase II study of single‐agent bortezomib for the treatment of patients with fludarabine‐refractory B‐cell chronic lymphocytic leukemia (2006)

Therapeutic options are limited and the prognosis is poor for patients with fludarabine-refractory B-cell chronic lymphocytic leukemia (CLL). Bortezomib induces apoptosis in vitro in CLL cells, both alone and in combination, including in cells resistant to fludarabine or other agents. The aim of the current randomized, open-label, Phase II study was to investigate the clinical activity of bortezomib in patients with fludarabine-refractory B-cell CLL. Twenty-two patients with histologically confirmed B-cell CLL were treated with bortezomib at doses of 1.0 mg/m2, 1.3 mg/m2, or 1.5 mg/m2 on Days 1, 4, 8, and 11 of a 21-day treatment cycle for a maximum of 9 cycles. None of 19 patients evaluable for response achieved complete remission or partial response; however, signs of biologic activity based on disease site responses (e.g., reduction in lymphocytosis, splenomegaly, and lymphadenopathy) were observed. In the 1.5 mg/m2 dose group, a higher proportion of patients had stable disease, and a lower proportion had progressive disease compared with the 2 lower-dose groups. Eleven patients, all in the 2 higher dose groups, experienced Grade 3/4 adverse events (AEs) (according to National Cancer Institute Common Toxicity Criteria [version 2.0]); 2 patients experienced Grade 4 neutropenia. Grade 3 hematologic AEs included anemia, neutropenia, thrombocytopenia, and hemolytic anemia; Grade 3 nervous system AEs included aphasia; peripheral neuropathy, not otherwise specified; and peripheral sensory neuropathy. Although no objective responses were achieved in patients with fludarabine-refractory B-cell CLL, single-agent bortezomib demonstrated biologic activity. In view of the evidence for its activity, further exploration of bortezomib in combination with other agents is warranted.
New England Coastal Waters—An Infinite Estuary (1975)

The crux of this paper is to assess the effects of the mixing of near-shore water of low salinity with oceanic waters of high salinity on the distribution of a non-conservative property, namely phosphate. The predictive model uses salinity as a tracer of freshwater. The proportion of the two sources (inshore and offshore) are expressed as a mixing ratio. It is assumed that phosphate in the two sources mixes following the proportions in each source. The trend of phosphate inshore to offshore predicted, agrees with the concentration measured in the surface, and the model estimates the amount of phosphate taken up by biological processes.