gebhart/patrepeval huggingface dataset:
Differences in Suppressor of Cytokine Signaling-1 (SOCS-1) Expressing Islet Allograft Destruction in Normal BALB/c and Spontaneously-Diabetic NOD Recipient Mice (2005)

These results demonstrate that expression of SOCS-1 in islets delays islet allograft rejection but cannot circumvent destruction of the islets by the recurrence of the tissue-specific autoimmune process of spontaneous diabetes.
Precise Measurement of $D^0$, $D^{\pm}$ and $D^{\pm}_s$ Meson Lifetimes (1993)

The measurements of the $D^)$, $D^{\pm}$ and$D^{\pm}_s$; meson lifetimes are described.
Design and Development of a Novel Biostretch Apparatus for Tissue Engineering (2009)

A uniaxial cyclic stretch apparatus is designed and developed for tissue engineering research. The biostretch apparatus employs noncontact electromagnetic force to uniaxially stretch a rectangular Gelfoam or RTV silicon scaffold. A reliable controller is implemented to control four stretch parameters independently: extent, frequency, pattern, and duration of the stretch. The noncontact driving force together with the specially designed mount allow researchers to use standard Petri dishes and commercially available CO(2) incubators to culture an engineered tissue patch under well-defined mechanical conditions. The culture process is greatly simplified over existing processes. Further, beyond traditional uniaxial stretch apparatuses, which provide stretch by fixing one side of the scaffolds and stretching the other side, the new apparatus can also apply uniaxial stretch from both ends simultaneously. Using the biostretch apparatus, the distributions of the strain on the Gelfoam and GE RTV 6166 silicon scaffolds are quantitatively analyzed.
CH Bond Activation by Rhodium(I) Hydroxide and Phenoxide Complexes (2007)

Rhodium(I) complexes of the form [(PNP)Rh(OR)] (R=H, CH2CF3, C6H5; PNP=2,6-bis[(di-tert-butylphosphino)methyl]pyridine) have been prepared. Upon thermolysis in [D6]benzene, the hydroxide and trifluoroethoxide complexes undergo benzene activation. [(PNP)Rh(OC6H5)] is an active catalyst for the H/D exchange between D2O and benzene and between H2O and [D8]toluene (see scheme), for which exchange occurs selectively at the meta and para positions. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z700270_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Mathematical analysis of Westwood1TCP congestion control (2005)

TCP congestion control is based on an additive-increase/multiplicative-decrease (AIMD) probing paradigm aimed at adapting the sending rate of TCP data sources to match the Internet time- varying available bandwidth. Westwoodþ TCP has been recently proposed to improve the tracking of available bandwidth of classic TCP. It is based on an end-to-end estimate of the available bandwidth, which is obtained by properly counting and filtering the stream of acknowledgement packets. The estimate is used to adaptively decrease the congestion window and slow start threshold after congestion so that it can be said that Westwoodþ TCP substitutes the classic multiplicative decrease with an adaptive decrease paradigm. The authors propose a mathematical analysis of the additive-increase=adaptive-decrease (AIADD) paradigm to analyse the steady-state throughput provided by Westwoodþ TCP and investigate the intra-protocol fairness of the AIADD paradigm and the inter-protocol friendliness between AIADD and AIMD algorithms. It is shown that (i) both classic and Westwoodþ TCP provide a throughput that is proportional to 1= ffiffiffi p p , where p is the segment drop probability, that is they are friendly to each other; and (ii) the throughput of Westwoodþ TCP is proportional to 1= ffiffiffiffiffiffiffiffiffi p , where RTT is the round trip time, whereas the throughput of Reno TCP is proportional to 1=RTT, i.e. Westwoodþ TCP improves the intra-protocol fairness. Finally, Ns-2 simulations are reported in order to validate the mathematical model in the presence of a wide range of network loads, loss probabilities and round trip times.
Synthesis, Electrochemical Properties and Self‐Assembly of a Proton‐Conducting Core–Shell Macromolecule (2012)

Let the protons flow: The synthesis of a core–shell macromolecule bearing phosphonic acids is presented. The rigid central core serves as a scaffold to stabilize the flexible polymer shells. Pronounced proton conductivity is obtained under humidified conditions. The self-assembly of such dendritic macromolecules by electrostatic interactions on a modified gold substrate is investigated and characterized.
Studies of antimicrobial activity of picryl amino pyridine N-oxides (2010)

Biologically active picryl amino pyridines and their N-oxide have been successfully synthesized and screened for their antimicrobial potency to set-up the structure activity relationships and found to possess better antibacterial activity than antifungal activity.
Carrier recombination mechanisms and efficiency droop in GaInN/GaN light-emitting diodes (2010)

We model the carrier recombination mechanisms in GaInN/GaN light-emitting diodes as R=An+Bn2+Cn3+f(n), where f(n) represents carrier leakage out of the active region. The term f(n) is expanded into a power series and shown to have higher-than-third-order contributions to the recombination. The total third-order nonradiative coefficient (which may include an f(n) leakage contribution and an Auger contribution) is found to be 8×10−29 cm6 s−1. Comparison of the theoretical ABC+f(n) model with experimental data shows that a good fit requires the inclusion of the f(n) term.
Fast Automated Approach for the Derivation of Acellular Extracellular Matrix Scaffolds from Porcine Soft Tissues (2020)

Decellularized extracellular matrix (ECM) scaffolds derived from tissues and organs are complex biomaterials used in clinical and research applications. A number of decellularization protocols have been described for ECM biomaterials derivation, each adapted to a particular tissue and use, restricting comparisons among materials. One of the major sources of variability in ECM products comes from the tissue source and animal age. Although this variability could be minimized using established tissue sources, other sources arise from the decellularization process itself. Overall, current protocols require manual work and are poorly standardized with regard to the choice of reagents, the order by which they are added, and exposure times. The combination of these factors adds variability affecting the uniformity of the final product between batches. Furthermore, each protocol needs to be optimized for each tissue and tissue source making tissue-to-tissue comparisons difficult. Automation and standardization of ECM scaffold development constitute a significant improvement to current biomanufacturing techniques but remains poorly explored. This study aimed to develop a biofabrication method for fast and automated derivation of raw material for ECM hydrogel production while preserving ECM composition and controlling lot-to-lot variability. The main result was a closed semibatch bioreactor system with automated dosing of decellularization reagents capable of deriving ECM material from pretreated soft tissues. The ECM was further processed into hydrogels to demonstrate gelation and cytocompatibility. This work presents a versatile, scalable, and automated platform for the rapid production of ECM scaffolds.
Psychosis among "healthy" siblings of schizophrenia patients (2006)

Register information cannot be used to exclude psychotic disorders among siblings of patients with schizophrenia. The high rate of emergence of new psychotic disorders among initially healthy siblings should be taken into account in genetic analysis.
A Three-Level Isolated AC–DC PFC Power Converter Topology With a Reduced Number of Switches (2019)

The main objective of this research work is to develop a new low-cost isolated three-level ac–dc power converter topology with a reduced number of switches. Existing three-level converter topologies change ac power to dc power while maintaining requirements set by international standards for power conversion. These types of converters have significant conduction losses due to high currents in the low-voltage side and high costs, mainly when using several active devices in series or in parallel to achieve high-voltage and high-power levels. The proposed topology replaces the conventional three-level converters in the secondary side by only two controlled devices and four diodes while still maintaining the basic functionality of a three-level converter. Furthermore, simulation results for a 25-kW case study and experimental results on a 900-W scale-down prototype demonstrate the feasibility of the proposed ideas.
Metallic islands in the Kondo insulator SmB6 (2020)

The predicted interplay between Kondo physics and nontrivial topology in SmB6 has stimulated many experimental reports, some of which are in apparent contradiction. The origin of the dispute may lie in the fragility of the Kondo insulating phase in the presence of Sm vacancies (Kondo holes) and/or natural impurities, such as Gd3+. In this work, we locally investigate this fragility for Al flux grown Sm1−xGdxB6 single crystals (0≤x≤0.02) by combining electron spin resonance (ESR) and complementary bulk measurements. The Gd3+ ESR spectra in a highly dilute regime (x∼0.0004) display the features of an insulating cubic environment. Remarkably, a metallic ESR line shape is observed for more concentrated samples (x≥0.004), even though these systems are still in a reasonably dilute regime and show insulating dc electrical resistivity. Our data indicate that the Kondo insulating state is destroyed locally around impurities before a global percolation occurs. This result not only explains the discrepancy between dc and ac conductivity but also provides a scenario to explain the presence of quantum oscillations in magnetization in the absence of quantum oscillations in electrical resistivity.Received 2 June 2020Accepted 7 October 2020DOI:https://doi.org/10.1103/PhysRevResearch.2.043181Published by the American Physical Society under the terms of the Creative Commons Attribution 4.0 International license. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI.Published by the American Physical SocietyPhysics Subject Headings (PhySH)Research AreasKondo effectTopological insulatorsPhysical SystemsKondo insulatorsTechniquesElectron spin resonanceCondensed Matter & Materials Physics
Radiographic Spinal Profile Changes Induced by Cage Design After Posterior Lumbar Interbody Fusion (2001)

These results show that normal sagittal alignment after single-level lumbar fusion can be achieved with rectangular and 4 degrees wedged cages. Although results after utilization of 4 degrees wedged cages do not significantly differ, these implants offer the surgeon one more sizing variation with which physiologic lumbar lordosis may be attained. The biomechanical implications of wedged implants on the rigidity of a fused segment remain to be analyzed.
Incomplete lysis of thrombus in the moderate underlying atherosclerotic lesion during intracoronary infusion of streptokinase for acute myocardial infarction: quantitative angiographic observations. (1986)

Thrombolytic recanalization of the obstructed coronary lumen was studied in 32 patients receiving intracoronary streptokinase for 60 to 90 min during acute myocardial infarction. The process was viewed at high arteriographic magnification and was quantified with computer-assisted measurements from repeated single-plane views. The variability of the method for this application was 0.15 to 0.18 mm on minimum diameter estimates. Structural details were seen that are not commonly appreciated at conventional magnification. The recanalized lumen appears to form along an interface between the thrombus and the vessel wall, progressively enlarging its minimum arteriographic diameter to 0.65 +/- 0.24 mm (+/- 1 SD) at the end of the short-term infusion of streptokinase reflecting a final percent stenosis of 77 +/- 10%. In nine infarct lesions found patent 5 +/- 3 weeks later, the recanalized lumen further improved an average of 0.34 mm in minimum diameter (p less than .005) and 13% stenosis (p less than .01). A thin...
Acyl-Coenzyme A Dehydrogenases Are Localized on GLUT4-Containing Vesicles via Association with Insulin-Regulated Aminopeptidase in a Manner Dependent on Its Dileucine Motif (2002)

Insulin-regulated aminopeptidase (IRAP, also termed vp165) is known to be localized on the GLUT4-containing vesicles and to be recruited to the plasma membrane after stimulation with insulin. The cytoplasmic region of IRAP contains two dileucine motifs and acidic regions, one of which (amino acid residues 55-82) is reportedly involved in retention of GLUT4-containing vesicles. The region of IRAP fused with glutathione-S-transferase [GST-IRAP(55-82)] was incubated with lysates from 3T3-L1 adipocytes, leading to identification of long-chain, medium-chain, and short-chain acyl-coenzyme A dehydrogenases (ACDs) as the proteins associated with IRAP. The association was nearly abolished by mutation of the dileucine motif of IRAP. Immunoblotting of fractions prepared from sucrose gradient ultracentrifugation and vesicles immunopurified with anti-GLUT4 antibody revealed these ACDs to be localized on GLUT4-containing vesicles. Furthermore, 3-mercaptopropionic acid and hexanoyl-CoA, inhibitors of long-chain and medium-chain ACDs, respectively, induced dissociation of long-chain acyl-coenzyme A dehydrogenase and/or medium-chain acyl-coenzyme A dehydrogenase from IRAP in vitro as well as recruitment of GLUT4 to the plasma membrane and stimulation of glucose transport activity in permeabilized 3T3-L1 adipocytes. These findings suggest that ACDs are localized on GLUT4-containing vesicles via association with IRAP in a manner dependent on its dileucine motif and play a role in retention of GLUT4-containing vesicles to an intracellular compartment.
FIT Student UAV Team Project (2009)

n its simplest form, the Unmanned Air Vehicle (UAV) or Unmanned Air System (UAS), is a pilotless plane. It is a small aircraft, with an on-board computer, or, microprocessor, together with control, sensor and communication electronics. There are both remote controlled UAVs and Autonomous UAV which depend on their onboard computer for all flight calculations. The purpose of this project is to construct and fly a student designed UAV within a single semester of work. The UAV will contain a variable payload ranging from onboard-data storage cameras to model missile and laser tag systems depending on mission requirements. The use of a multifunctional payload bay will be key to creating a UAV that can be used by future students or faculty to jump test experiments at low costs. I
Insulin Pumps and Continuous Glucose Monitoring Made Easy (2015)

Insulin pumps and continuous glucose monitoring made easy / , Insulin pumps and continuous glucose monitoring made easy / , کتابخانه دیجیتالی دانشگاه علوم پزشکی و خدمات درمانی شهید بهشتی
[Clinical observation of macular disease in patients with diabetic retinopathy]. (1991)

The population was 65 cases (122 eyes) of diabetic macular disease. Background diabetic retinopathy was observed in 40 eyes, i.e., 32.80%. For the 82 eyes present proliferative diabetic retinopathy, i.e., 67.20%. According to Sigelmen's classification, 17 eyes were in stage I, i.e., 13.93% of the cases; 41 eyes were in stage II, i.e., 33.60% of the cases; 40 eyes were in stage III, i.e., 32.80% of the cases; 24 eyes were in stage IV, i.e., 19.67% of the cases. There were 122 eyes in this group. The visual acuity of 66 eyes showed > or = 0.3, i.e., 54.00%, while that of 56 eyes showed 40.3 i.e. 46.00%. Nearly half patients showed low visual acuity and loss of vision. This result was responsible for the cases who were at the late stage of diabetic and with a long history of diabetic or the diabetic was poorly controlled. So the writer appeal to ophthalmologists and physicians to prescribe the effective guides to all the diabetic patients. We suggest that it is important that dynamic observation be carried out of hemorhelological manifestation and early treatment diabetic retinopathy for the clinical prevention and treatment of diabetic retinopathy.
Towards a Common Computational Synthesis Framework with Object-Process Methodology (2003)

The field of computational synthesis is emerging is an inter-disciplinary effort that encompasses applications in a variety of knowledge domains. Each domain has its own ontology, modeling methods, set of symbols, and syntax. The cross-cutting commonalities among the various implementation domains, which make computational synthesis a research do-main in its own right, are articulated for the most part only in natural language. The computational synthesis community may greatly benefit from an agreement on a domain-independent paradigm and modeling methodology that are shared among the various fields of knowledge in which com-putational synthesis is or will be applied. This paper proposes Object-Process Methodology (OPM) as a unifying framework for modeling in a balanced and transparent way how the ar-chitecture, i.e., the combination of structure (objects) and be-havior (processes) of the system being evolved fulfill the functional requirements (measured by fitness) for its survival in the environment. OPM specifies not only the evolvable life form as a final product, but also the universal computational synthesis metamodel – the model of the system that makes this evolution happen.
Measuring Noncalcified Coronary Atherosclerotic Plaque Using Voxel Analysis with MDCT Angiography: Phantom Validation (2008)

There appears to be no significant difference (< 3%) between MDCT and micro-CT measurements.
Highly Carboxylated, Cellular Structured, and Underwater Superelastic Nanofibrous Aerogels for Efficient Protein Separation (2019)

Abstract Chromatographic media with synchronously large protein adsorption capacity and high processing flux are highly desired in protein separation; however, the creation of such materials still faces enormous challenges. Herein, a robust strategy to develop highly carboxylated monolithic media by combining nanofibrous aerogels' forming technique and an in situ modification approach is reported. The obtained ion‐exchange nanofibrous aerogels (IENFAs) exhibit a unique cellular structure consisting of flexible ceramic nanofibers and a functional polymer wrapping layer, endowing them with outstanding underwater superelasticity and compressive fatigue resistance (nearly no plastic deformation after 1000 compressive cycles). Benefiting from the interconnected nanofibrous cellular structure, good hydrophilicity, high carboxylation, and excellent mechanical properties, the IENFAs exhibit synchronously promoted static (2.9 × 10 3 mg g −1 ) and dynamic (1.7 × 10 3 mg g −1 ) lysozyme adsorption capacities and improved buffer flux (2.17 × 10 4 L m −2 h −1 , gravity driven), which are superior to these reported nanofibrous materials and commercial ion‐exchange membranes. The IENFAs also possess outstanding performance stability, easy operation, and excellent regenerability. Moreover, the IENFA‐packed column could directly and continuously separate lysozyme from egg white solely driven by gravity, highlighting their excellent practical application performance. This work may provide a new avenue to design and develop next‐generation high‐performance chromatographic media for bioseparation.
HIV Latency: Present Knowledge and Future Directions (2006)

Current therapies do not eradicate HIV from infected patients. Indeed, HIV hides in a latent form insensitive to these therapies. Thus, one priority is to purge these latent reservoirs. But what mechanisms are responsible for latency and what are the reservoirs of latently infected cells? The present knowledge in terms of HIV latency is still incomplete and current therapeutic strategies fail to eradicate completely latently infected cells. What could the future bring?
PROJECTED COSTS OF IN-VEHICLE INFORMATION SYSTEMS: METHODOLOGY AND APPLICATION (1997)

In-Vehicle Information Systems (IVIS), currently under development, are a keystone of intelligent transportation systems (ITS). IVIS are designed to acquire, filter, prioritize, and display information about the driving environment to the driver of a road vehicle. As IVIS are developed, it is important to estimate their cost-effectiveness. The paper develops and applies a cost estimation methodology, that is consistent with the national ITS architecture, to make projections of the costs of IVIS. Projections are based on the costs of the equipments' components. Economies of scale and an industry-experience curve are also incorporated into these estimates. The methodology also provides estimates of the incremental costs for vehicle users, infrastructure requirements, and deployment of additional ITS services. Cost projections for two market packages (i.e., broadcast traveler information and interactive traveler information) are made for the Urbansville and Thruville scenarios considered in the national ITS architecture study for a 10-year deployment period. Results for the Urbansville and Thruville scenarios indicate life cycle costs (in 1996 dollars) of $87 million and $13 million, respectively, for the broadcast traveler information market package. Life cycle costs of the interactive traveler information market package are about 1.3 times higher. As with any cost projections, their validity depends on accurate assumptions about the IVIS designs and concepts, and on the availability of reliable cost data for individual equipment components.
Systems‐level interactions between insulin–EGF networks amplify mitogenic signaling (2009)

Crosstalk mechanisms have not been studied as thoroughly as individual signaling pathways. We exploit experimental and computational approaches to reveal how a concordant interplay between the insulin and epidermal growth factor (EGF) signaling networks can potentiate mitogenic signaling. In HEK293 cells, insulin is a poor activator of the Ras/ERK (extracellular signal-regulated kinase) cascade, yet it enhances ERK activation by low EGF doses. We find that major crosstalk mechanisms that amplify ERK signaling are localized upstream of Ras and at the Ras/Raf level. Computational modeling unveils how critical network nodes, the adaptor proteins GAB1 and insulin receptor substrate (IRS), Src kinase, and phosphatase SHP2, convert insulin-induced increase in the phosphatidylinositol-3,4,5-triphosphate (PIP(3)) concentration into enhanced Ras/ERK activity. The model predicts and experiments confirm that insulin-induced amplification of mitogenic signaling is abolished by disrupting PIP(3)-mediated positive feedback via GAB1 and IRS. We demonstrate that GAB1 behaves as a non-linear amplifier of mitogenic responses and insulin endows EGF signaling with robustness to GAB1 suppression. Our results show the feasibility of using computational models to identify key target combinations and predict complex cellular responses to a mixture of external cues.