gebhart/patrepeval huggingface dataset:
Principles of genome sciences. (2019)

<title>Abstract</title> This chapter describes the major disciplinary areas of genomics that have been explored in and utilized for various tree species. It will serve as a foundation for the remaining chapters in Section I of this book.
The free radical‐generating function of a familial amyotrophic lateral sclerosis‐associated D90A Cu,Zn‐superoxide dismutase mutant (1998)

The free radical-generating functions of the D90A Cu,Zn-superoxide dismutase (SOD) associated with Swedish familial amyotrophic lateral sclerosis (FALS) patients are investigated. The results show that both the wild-type and mutant enzymes have identical dismutase activity, while the free radical-generating activity of the D90A mutant is enhanced relative to that of the wild-type enzyme. The studies suggest that the active channel of the D90A mutant is larger than that of the wild-type enzyme. A higher free radical-generating activity of the mutant enzyme led to the release of copper ions from the damaged protein. The generation of strand breaks in plasmid DNA was enhanced more effectively by the D90A mutant Cu,Zn-SOD than by the wild-type enzyme. The results suggest that the pathology of FALS may be attributed to oxidative damage caused by the gain-of-function of FALS Cu,Zn-SOD mutant.
Highly Sensitive and Selective Ethanol Sensor Based on ZnO Nanorod on SnO2 Thin Film Fabricated by Spray Pyrolysis (2019)

This work reports the fabrication of mixed structure of ZnO nanorod on SnO2 thin film via spray pyrolysis followed by thermal annealing and their gas sensing properties. ZnO/SnO2 nanostructures are successfully prepared on a gold interdigitated alumina substrate by spraying varying mixed precursor concentrations of zinc acetate and tin (IV) chloride pentahydrate solutions in ethanol and thermal annealing. The morphology of the nanostructures is controlled by tailoring the Zn:Sn ratio in the precursor solution mixture. Unique ZnO crystals and ZnO nanorods are observed under a field emission scanning electron microscopy (FESEM) when the Zn/Sn ratio in the precursor solution is in between 13:7 to 17:3 after thermal annealing. The fabricated nanostructures are tested for ethanol, methane and hydrogen in air ambient for various gas concentrations ranging from 25 ppm to 400 ppm and the effect of fabrication conditions on the sensitivity and selectivity are studied. Among the nanostructure sensors studied, the film fabricated with molar ratio of Zn/Sn =3:1 shows better sensitivity and selectivity to ethanol due to high sensing surface area of nanorod. The response to 25 ppm ethanol is found to be as high as 50 at an operating temperature of 400ºC.
Cardioselective Antiischemic ATP-Sensitive Potassium Channel Openers. 4. Structure−Activity Studies on Benzopyranylcyanoguanidines:  Replacement of the Benzopyran Portion (1996)

The results of our efforts aimed at the replacement of the benzopyran ring of the lead cardiac selective antiischemic ATP-sensitive potassium channel (KATP) opener (4) are described. Systematic modification of the benzopyran ring of 4 resulted in the discovery of a structurally simpler acyclic analog (8) with slightly lower antiischemic potency than the lead compound 4. Further structure-activity studies on the acyclic analog 8 provided the 2-phenoxy-3-pyridylurea analog 18 with improved antiischemic potency and selectivity compared to the benzopyran-based compound 4. These data demonstrate that the benzopyran ring of 4 and its congeners is not mandatory for antiischemic activity and cardiac selectivity. The results described in this paper also show that, as for the benzopyran class of compounds, the structure-activity relationships for the antiischemic and vasorelaxant activities of KATP openers are distinct. The mechanism of action of the acyclic analogs (e.g., 18) still appears to involve KATP opening as their cardioprotective effects are abolished by pretreatment with the KATP blocker glyburide.
Lack of Microbial Genetic Response to 2.45-GHz CW and 8.5- to 9.6-GHz Pulsed Microwaves (1979)

Strain D4 of the yeast Saccharomyces cerevisiae, and strains TA-1535, TA-100 and TA-98 of the bacterium Salmonella typhimurium, were exposed to 2.45-GHz continuous wave or 8.5- to 9.6-GHz pulsed electromagnetic radiation (EMR) at various power densities from 1 to 45 mW/cm2. The temperature during radiation was maintained at 30 degrees C for yeast cultures and at 37 degrees C for bacterial cultures. The studies revealed no increase in mutations or of mitotic gene conversions when cells were radiated for two hours or less. Decreased viability of cells was noted in all cultures tested after radiation at power densities of 30 mW/cm2 or more; however, no reliable changes in genetic events occurred.
Accelerating Convolutional Neural Network Inference Based on a Reconfigurable Sliced Systolic Array (2021)

Convolutional neural networks (CNNs) have achieved great successes on many computer vision tasks, such as image recognition, video processing, and target detection. In recent years, many hardware designs have been devoted to accelerating CNN inference. In order to further speed up CNN inference and reduce data waste, this work proposed a reconfigurable sliced systolic array: 1) Depending on the number of network nodes in each layer, the slice mode could be dynamically configured to achieve high throughput and resource utilization. 2) To take full advantage of convolution reuse and weight reuse, this work designed a tile-column sliding (TCS) processing dataflow. 3) A four-stage for loop algorithm was employed, which divides the CNN calculation into several parts based on the input nodes and output nodes. The entire CNN inference is carried out using integer-only arithmetic originated from TensorLite. Experimental results prove that these strategies lead to significant improvement in inference performance and energy efficiency.
Eruption Rates, Tempo, and Stratigraphy of Paleocene Flood Basalts on Baffin Island, Canada (2022)

Abstract High‐temperature melting in mantle plumes produces voluminous eruptions that are often temporally coincident with mass extinctions. Paleocene Baffin Island lavas—products of early Iceland mantle plume activity—are exceptionally well characterized geochemically but have poorly constrained stratigraphy, geochronology, and eruptive tempos. To provide better geologic context, we measured seven stratigraphic sections of the volcanic deposits and collected paleomagnetic data from 38 sites in the lavas and underlying Cretaceous sediments (Quqaluit Fm.). The average paleomagnetic pole from this study does not overlap with the expected pole for a stable North American locality at 60 Ma, yet the data have sufficient dispersion to average out secular variation. After ruling out other possibilities, we find that the picrites were probably erupted during a polarity transition, over less than 5 kyr. If so, the average eruption interval was ∼67 years per flow for the thickest sequence of exposed lavas. We also calculate that the flood basalts had a minimum total volume of ∼176 km 3 (excluding submerged lavas in Baffin Bay). This implies a minimum eruption rate of ∼0.035 km 3 yr −1 , which is similar to rates found in West Greenland lavas but less than rates found in larger flood basalts. Despite this, the Baffin and West Greenland lavas temporally correlate with the “End C27n event” (a period of ∼2°C global warming) and may be its underlying cause.
Cardiac involvement with human T-cell lymphotrophic virus type-1-associated adult T-cell leukemia/lymphoma: The NIH experience (2008)

Malignant cardiac involvement is rare in patients with human T cell lymphotrophic virus type-1-associated adult T cell leukemia/lymphoma (ATLL). We report a single institution experience of eight patients with pathologically documented cardiac involvement with ATLL. Pericardial effusion and tamponade, cardiac valvular infiltration, valve leaflet tumor nodules and endocardial and myocardial tumors were observed. Cardiac involvement with ATLL was most often identified post-mortem; however, three cases were diagnosed clinically. All but one of the patients had the acute or lymphomatous subtypes of ATLL and had progressed through at least one prior systemic therapy. Patients with ATLL-related cardiac disease were also found to have pulmonary involvement suggesting that this may be a sign of increased risk of cardiac involvement. One patient with the chronic form of ATLL remains alive 10 years after undergoing cardiac valve replacement.
A Fundamental Relationship between Hydrophobic Properties and Biological Activity for the Duocarmycin Class of DNA-Alkylating Antitumor Drugs: Hydrophobic-Binding-Driven Bonding (2013)

Two systematic series of increasingly hydrophilic derivatives of duocarmycin SA that feature the incorporation of ethylene glycol units (n = 1-5) into the methoxy substituents of the trimethoxyindole subunit are described. These derivatives exhibit progressively increasing water solubility along with progressive decreases in cell growth inhibitory activity and DNA alkylation efficiency with the incremental ethylene glycol unit incorporations. Linear relationships of cLogP with -log IC50 for cell growth inhibition and -log AE (AE = cell-free DNA alkylation efficiency) were observed, with the cLogP values spanning the productive range of 2.5-0.49 and the -log IC50 values spanning the range of 11.2-6.4, representing IC50 values that vary by a factor of 10(5) (0.008 to 370 nM). The results quantify the fundamental role played by the hydrophobic character of the compound in the expression of the biological activity of members in this class (driving the intrinsically reversible DNA alkylation reaction) and define the stunning magnitude of its effect.
Direct and titrimetric determination of hydrogen peroxide by reverse pulse polarography (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDirect and titrimetric determination of hydrogen peroxide by reverse pulse polarographyAlicia. Brestovisky, Emilia. KirowaEisner, and Janet. OsteryoungCite this: Anal. Chem. 1983, 55, 13, 2063–2066Publication Date (Print):November 1, 1983Publication History Published online1 May 2002Published inissue 1 November 1983https://pubs.acs.org/doi/10.1021/ac00263a013https://doi.org/10.1021/ac00263a013research-articleACS PublicationsRequest reuse permissionsArticle Views154Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Sodium Channel Blockers as Therapeutic Target for Treating Epilepsy: Recent Updates (2012)

The voltage-gated sodium channels (VGSCs) are a family of membrane proteins forming a pore, through which they selectively conduct sodium ions inward and outward cell's plasma membranes in response to variations of membrane potentials, playing a fundamental role in controlling cellular excitability. Growing evidences suggest that abnormal VGSCs are involved in the pathophysiology of both acquired and inherited epilepsy. Approximately two dozen drugs are currently marketed for the treatment of epilepsy and most of them act as sodium channel blockers, preventing the return of the channels to the active state by stabilizing the inactive form. Despite the many drugs on the market, 30% of patients continue to experience seizures even in the presence of optimal doses of AEDs, while others continue to suffer from medication induced side effects. Thus, there is a great need to continue the search for new AEDs that are not only more effective, but also have a better side effects profile. For this reason, many efforts have been made in the recent years to identify new sodium channel blockers for the treatment of epilepsy. These studies have led to different classes of compounds, characterized by a great structural diversity. The aim of this review is to provide an introduction on the structure and function of the sodium channels, followed by a brief historical perspective on the sodium channel blockers in use as anticonvulsant drugs. Moreover, it will focus on the medicinal chemistry of the sodium channel blockers recently published (2008-2011) and the drug design/molecular modeling studies related to the receptor.
Activation of a pertussis‐toxin‐sensitive guanine‐nucleotide‐binding regulatory protein during desensitization of Dictyostelium discoideum cells to chemotactic signals (1991)

The chemoattractant cAMP induces the activation of adenylate cyclase in Dictyostelium discoideum. Upon prolonged incubation with cAMP, cells become desensitized via two distinct processes: a decrease in the number of available cAMP-binding sites (down regulation) and modification of the receptor (presumably via phosphorylation) correlated with adaptation. These processes occur simultaneously, but differ in the cAMP dose dependency and reversibility. In this study we investigated the mechanism of adaptation; cells were incubated with a cAMP analog to induce desensitization mediated by adaptation. The cells were then washed, lysed and the interaction between cAMP, receptor, guanine-nucleotide-binding regulatory proteins (G proteins) and GTP was investigated. (1) cAMP receptors that are phosphorylated in vivo remain phosphorylated for at least 45 min after lysis. (2) Desensitization did not alter basal cAMP binding to the receptor nor the inhibitory effect of guanosine 5'-[gamma-thio]triphosphate (GTP[S]) on this binding. (3) The stimulatory effect of cAMP on GTP[S] binding was also unchanged, while basal GTP[S] binding and the kinetics of binding were only slightly different. (4) Basal high-affinity GTPase activity was not altered but cAMP stimulation was reduced from 43 +/- 7% in control lysates to 14 +/- 4% in lysates from desensitized cells. (5) cAMP stimulation of GTPase was decreased by pretreatment of cells with pertussis toxin from 43 +/- 7% to 17 +/- 8% but this was not further altered in lysates from desensitized pertussis-toxin-treated cells. These observations indicate that during desensitization the phosphorylated receptor can still interact with G proteins. Furthermore, desensitization did not affect cAMP stimulation of GTP[S] binding but strongly reduced cAMP stimulation of GTPase, suggesting that a G protein becomes activated. This G protein is pertussis toxin sensitive and may be the inhibitor G protein (Gi). This would imply that adenylate cyclase desensitizes because Gi becomes activated.
Three-phase dual active bridge converter design considerations (2017)

In three-phase dual-active-bridge (DAB) converter, the zero-voltage-switching (ZVS) range, DC capacitor ripple current and converter efficiency are significantly impacted by the selectable system parameters, including transformer turn ratio n, switching frequency f and leakage inductance L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">k</sub> . The converter performance also varies with different operation conditions, i.e., input voltage, output voltage and output power level. Therefore, these parameters need to be carefully selected to achieve optimized performances. In this paper, a comprehensive study of the parameter selection for the three-phase DAB converter is conducted under different operation conditions. A new parameter fL is defined to reduce the analysis from 3 dimensions to 2 dimensions, which simplifies the analysis of transformer turn ratio significantly. Furthermore, the effective operating area (EOA) of f and L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">k</sub> are defined for feasible transformer designs. The current stress of switches and DC capacitors are studied in the EOA to help determine the range of f and L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">k</sub> . Finally, the converter total loss and efficiency are analyzed at full and half load with different input and output voltages. The converter parameter (n, f, L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">k</sub> ) can be selected using ZVS and efficiency criteria. The tradeoff between high efficiency, wide ZVS area and low capacitor ripple current can be achieved accordingly.
Nonlinear adaptive control of spacecraft maneuvers (1997)

A novel method is presented to carry out near-minimum-time maneuvers of a spacecraft of unknown inertia. The formulation assumes the presence of three orthogonal reaction wheels located near the system mass center and oriented arbitrarily with respect to the spacecraft principal axes. Modie ed Rodrigues parameters along with their shadow set are used as the primary attitude coordinates. Open-loop maneuver laws are designed while solving the equations of motion by inversedynamics approach. This approach permits theapproximateimposition of the maximum saturation torque constraint. The torque proe les are near-bang-bang, with the instantaneous switches replaced by cubicsplinesof specie edduration.An adaptivetrackingcontrollawisdeveloped to determine perturbations to the nominal open-loop torque commands that will ensure the actual motion to follow the nominal motion in the presence of uncertainty in the inertia matrix and errors in the initial attitude. Global stability of the overall closed-loop controller is proved analytically and demonstrated by numerical simulations.
Growth Performance, Meat Yield, and Economic Responses of Broilers Provided Diets Varying in Amino Acid Density from Thirty-Six to Fifty-Nine Days of Age (2006)

Providing broilers diets formulated to a high amino acid density early in life improves subsequent growth performance and meat yield. Diets formulated to high amino acid concentrations beyond 5 wk of age may increase breast meat yield but may not be economically justified. This study examined growth, meat yield, and economic responses of broilers provided diets varying in amino acid density from 36 to 59 d of age. Birds were given a 4-phase feeding program: starter (1 to 17 d), grower (18 to 35 d), withdrawal-1 (WD1; 36 to 47 d), and withdrawal-2 (WD2; 48 to 59 d of age). All birds were fed a common, high amino acid density diet to 35 d of age (HH). Broilers were provided diets characterized as being high (H), moderate (M), or low (L) in amino acid density for the WD1 and WD2 periods. Dietary treatments were HHHH, HHHM, HHHL, HHMM, HHML, and HHLL from d 1 to 59, with H, M, and L representing the diets fed during each of the 4 periods (starter, grower, WD1 and WD2). Cumulative feed conversion was improved when the HHHH feeding regimen was fed, whereas other final live performance measurements were not affected. Decreasing amino acid density (HHLL and HHHL) limited yields of breast fillets, tenders, and total white meat when compared with the HHHH regimen. As amino acid density decreased from HHHH to HHHM, HHMM, and HHML, carcass yield and breast meat yield were not affected. In general, providing the HHHH feeding regimen increased economic gross feeding margin compared with the other dietary treatments.
Beamsteering in Pattern Reconfigurable Arrays Using Directional Modulation (2010)

An array with pattern-reconfigurable elements is used to generate a digital modulation by switching the elements for every symbol. This technique is known as directional modulation. Because the modulation is generated at the antenna level, it gives control over the directions in which data is sent, unlike baseband modulation which transmits the same data in all directions at different power levels. A procedure for determining how to switch the elements to transmit only in a specified direction is outlined. Results indicate that compared to a traditional reconfigurable array, the directional modulation array allows information to be sent over a narrower beamwidth. Additionally, the method provides more selectivity in the possible transmit angles. Measured and calculated results from a four-element reconfigurable array are presented.
Subfoveal choroidal thickness in ipsi‐ and contralateral eyes of patients with carotid stenosis before and after carotid endarterectomy: a prospective study (2020)

Subfoveal choroidal thickness (SFCT) is thinner in patients with CS without association between SFCT and the grade of CS. Unchanged SFCT after CEA suggests, that choroidal vessels in severe CS are unable to react to increased blood flow. Bilaterally thin SFCT could be considered as yet another sign of CS.
Diode-Laser-Based Sensor Measurements of Nitric Oxide and Carbon Monoxide in Combustion Exhaust Streams (2003)

All-solid-state continuous-wave (cw) laser systems for ultraviolet (UV) absorption measurements of the nitric oxide (NO) molecule and mid-infrared (IR) absorption measurements of carbon monoxide (CO) were developed and demonstrated. For the NO sensor, 250 nW of tunable cw UV radiation at 226.8 nm is produced by sum-frequency-mixing in a beta-barium borate crystal. For the CO sensor, 2μW of tunable cw IR radiation at 4.5 μm is produced by difference-frequency mixing in a periodically-poled lithium niobate crystal. A tunable external-cavity diode laser (ECDL) provides one of the fundamental beams for both processes so that the wavelength of the generated UV/IR can be tuned over NO/CO absorption lines to produce a fully resolved absorption spectrum. The sensors were used for measurements in the exhaust stream of an operating auxiliary power unit (APU) gas turbine engine and a well-stirred reactor (WSR). During these tests, NO was measured in the exhaust at levels below 10 ppm. For measurements at levels above 20 ppm, the NO emission levels obtained using the new sensor agreed with the results of probe sampling chemiluminescent analyzer results to within 10%. A detection limit of 0.8 ppm of per meter path length at 1000 K is estimated for the NO sensor. Measurements with the CO sensor demonstrated an agreement with extractive probe sampling to within 15%. The estimated detection limit of the CO sensor is a few ppm per meter path length at 1000 K.
16,16-Dimethyl Prostaglandin E 2 Increases Survival in Mice Following Irradiation (1987)

16,16-Dimethyl prostaglandin E2 (DiPGE2), a stable analog of PGE2, increases the LD50/30 survival in CD2F1 male mice when given prior to ionizing radiation. Subcutaneous administration of 40 micrograms of DiPGE2 30 min prior to 60Co gamma irradiation extends the LD50/30 from 9.39 Gy in the control animals to 16.14 Gy in DiPGE2 treated, with a dose reduction factor of 1.72 [95% confidence limits: 1.62, 1.82]. The degree of protection is dependent on both the time of administration and the dose of the prostaglandin. Ten micrograms administered 5 min prior to receiving a lethal dose of 10 Gy provides 90% survival but only 10% survival if administered 30 min prior to irradiation. Experiments to determine the in vivo concentration of DiPGE2 in organs postinjection show increased levels over time, but these are not correlated with protection. At 30 min after injection, as much as 80% of the DiPGE2 present in the spleen and plasma is unmetabolized. These results suggest that the protection results from the physiologic action of DiPGE2 rather than direct in vivo detoxification of radicals.