gebhart/patrepeval huggingface dataset:
Low-voltage motor control centers utilizing microprocessor technology (1993)

Low-voltage squirrel cage induction motors are used in cement mill conveyors, dust collectors, crushers, mills, separators, and fans. There are many types of starters used to control these motors, including manual, magnetic, solid state, and adjustable frequency. However, most motors in the 10 to 400 hp range use magnetic contactors with thermal overload relays. Recently, a new type of magnetic starter that includes a built-in microprocessor was invented. The author describes the design of this starter and the manner in which this new design is able to solve a variety of problems inherent with conventional magnetic motor starters.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Policy-based QoS management for SLA-driven adaptive routing (2013)

This paper proposes a policy-based quality of service (QoS) management framework for adaptive routing decisions. We present an approach considering interior gateway protocol (IGP) for path discovery mechanisms and QoS-aware policies for configuring the network elements. The integration of the aforementioned modules into this policy-based network management (PBNM) system is demonstrated by conducting experiments in a real environment, the hellenic public administration network SYZEFXIS. These experiments combine different traffic conditioning mechanisms through event detectors, consider IP service level agreement mechanisms that interoperate with the PBNM system and analyze the enforcement of IGP and QoS policies. Finally, validation and measurement tools are used to prove the efficiency of this framework. It is shown that this architecture offers significantly increased performance and learning capabilities, while the PBNM system achieves adaptive QoS routing through automated configuration considering the avoidance of suboptimal routing issues or under-performance conditions of the network entities.
Implantable and transdermal polymeric drug delivery technologies for the treatment of central nervous system disorders (2016)

The complexity of the brain and the membranous blood-brain barrier (BBB) has proved to be a significant limitation to the systemic delivery of pharmaceuticals to the brain rendering them sub-therapeutic and ineffective in the treatment of neurological diseases. Apart from this, lack of innovation in product development to counteract the problem is also a major contributing factor to a poor therapeutic outcome. Various innovative strategies show potential in treating some of the neurological disorders; however, drug delivery remains the most popular. To attain therapeutic drug levels in the central nervous system, large, intolerable systemic doses are generally administered. The major factors responsible for the success maintenance therapy of neurological diseases included controlled and sustained release of neurotherapeutics, reduced frequency of administration, higher bioavailability, and patient compliances. Conventional oral or injectable formulations cannot satisfy all the requirements in many circumstances. This article reviews the therapeutic implantable polymeric and transdermal devices employed in an attempt to effectively achieve therapeutic quantities of drug across the BBB over a prolonged period, to improve patient disease prognosis.
Josephson junction binary oscillator computing (2013)

The first modern computers were built at Manchester University in the late 1940s and amongst the principal components used were vacuum tube oscillators. Following the development of the transistor, such oscillator-based computers quickly became obsolete. Here, a novel application of superconducting Josephson Junction (JJ) technology based on neural dynamics is proposed. Neuron-type oscillators can be constructed from JJs and they can be connected together to form computer circuits in a manner entirely consistent with modern architectures. SIMetrix models of both computation and memory are presented and metrics are discussed. It has been estimated that JJs switch 100 times faster than their transistor counterparts and use 300 times less power (including the super-cooling). Utilizing the circuits described in this paper, it is also estimated that computers could be constructed using at least 10 times fewer components. Thus, theoretically these JJ-based computers could be up to 300,000 times more efficient than their CMOS counterparts.
Contribution of hMTH1 to the Maintenance of 8-Oxoguanine Levels in Lung DNA of Non-Small-Cell Lung Cancer Patients (2005)

Several different components contribute to the maintenance of 8-oxoG levels in human DNA, with the greatest contributor being the removal of 8-oxodGTP from the cellular nucleotide pool by hMTH1.
?-carotene supplementation for patients with low baseline levels and decreased risks of total and prostate carcinoma (1999)

These prespecified subgroup analyses appeared to support the idea that beta-carotene supplementation may reduce risk of prostate carcinoma among those with low baseline levels. Further follow-up of this population will help determine whether these findings are valid.
Performance improvement of soft-switched PWM rectifiers with inductive load (1997)

A new soft-switched AC/DC pulse width modulation (PWM) converter structure is presented. It is useful for current-fed inverters and PWM rectifiers. Typical applications are magnet power supplies, high-power AC motor drives, and active power filters with magnetic energy storage. Soft switching is provided at the expense of a limited increase of the circuit complexity as compared to usual hard-switching solutions. A discussion of the soft commutation process is presented. By a proper switching sequence, overvoltages across the converter switches can be fully eliminated. Moreover, light-load operation can be achieved. Both typical limitations of soft-switched current-fed topologies are therefore overcome. Simulation and experimental results demonstrate the actual converter capabilities.
Genome-wide Co-occurrence of Promoter Elements Reveals a cis-Regulatory Cassette of rRNA Transcription Motifs in Saccharomyces cerevisiae (2002)

Combinatorial regulation is an important feature of eukaryotic transcription. However, only a limited number of studies have characterized this aspect on a whole-genome level. We have conducted a genome-wide computational survey to identify cis-regulatory motif pairs that co-occur in a significantly high number of promoters in the S. cerevisiae genome. A pair of novel motifs, mRRPE and PAC, co-occur most highly in the genome, primarily in the promoters of genes involved in rRNA transcription and processing. The two motifs show significant positional and orientational bias with mRRPE being closer to the ATG than PAC in most promoters. Two additional rRNA-related motifs, mRRSE3 and mRRSE10, also co-occur with mRRPE and PAC. mRRPE and PAC are the primary determinants of expression profiles while mRRSE3 and mRRSE10 modulate these patterns. We describe a new computational approach for studying the functional significance of the physical locations of promoter elements that combine analyses of genome sequence and microarray data. Applying this methodology to the regulatory cassette containing the four rRNA motifs demonstrates that the relative promoter locations of these elements have a profound effect on the expression patterns of the downstream genes. These findings provide a function for these novel motifs and insight into the mechanism by which they regulate gene expression. The methodology introduced here should prove particularly useful for analyzing transcriptional regulation in more complex genomes.
Relations of morale and physical function to advanced activities of daily living in health promotion class participants (2016)

[Purpose] The aim of this study was to clarify the relations of morale and physical function to the presence/absence of advanced activities of daily living. [Subjects] The subjects were 86 elderly community residents participating in health promotion classes. [Methods] A questionnaire survey on age, gender, presence/absence of advanced activities of daily living, and Philadelphia Geriatric Center Morale Scale score was conducted, in addition to assessment of fitness, consisting of measurement of height, body weight, grip and knee extensor muscle strength, functional reach, one-leg standing time, and Timed Up and Go test. Furthermore, multiple logistic regression analysis was performed with the presence/absence of advanced activities of daily living as a dependent variable. [Results] Grip strength and Timed Up and Go time were identified as variables influencing the presence/absence of advanced activities of daily living. [Conclusion] Physical function represented by grip strength and Timed Up and Go time was higher among subjects performing advanced activities of daily living.
Treatment delay and outcomes of ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention during the COVID-19 era in South Korea (2022)

Reperfusion after STEMI treatment during the COVID-19 period was delayed; therefore, efforts should be made to improve on reperfusion.
ChemInform Abstract: Polycyclic Azines. Part 25. 2‐Amino‐3,1‐benzothiazin‐4‐ones: Synthesis, Dimroth Rearrangement to Quinazolin‐4(3H)‐on‐2(1H)‐thiones, and MS/MS‐ Fragmentation. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Improved Transposon-Based Library Preparation for the Ion Torrent Platform (2015)

A transposon-based approach for the construction of sequencing libraries is an efficient way of preparing samples for processing on both Illumina and Ion Torrent platforms. However, PCR-mediated incorporation of adaptors in tagged DNA fragments leaves behind self-complementary regions flanking the DNA fragment. These regions are capable of forming hairpin structures and, together with adaptors, create conditions for the potential formation of template heteroduplexes. These negatively affect the sequencing process on the Ion Torrent platform and can lead to a more than 3-fold decline in output data compared with sequencing of conventional libraries. To address this problem, we have developed MuPlus, a transposon-based protocol for barcoded library preparation for Ion Torrent, in which one adaptor is integrated by PCR and the second is integrated by ligation as a single-stranded oligonucleotide after enzymatic cleavage of a complementary part on one strand of the tag. The resulting library does not contain self-complementary, hairpin-forming regions, is free of heteroduplexes, and can be analyzed on the Ion Torrent platform with the same efficiency as a library created with a ligation-based protocol.
XML and electronic commerce (1998)

There has been a lot of talk about how the Internet is going to change the world economy. Companies will come together in a “plug and play” fashion to form trading partner networks. Virtual companies will be established and new business models can be created based on access to information and agents that can carry it around the world using computer networks.
Simulated microgravity produces attenuated baroreflex-mediated pressor, chronotropic, and inotropic responses in mice (2005)

Whether myocardial contractile impairment contributes to orthostatic intolerance (OI) is controversial. Accordingly, we used transient bilateral carotid occlusion (TBCO) to compare the in vivo pressor, chronotropic, and inotropic responses (parts 1 and 2) to open-loop selective carotid baroreceptor unloading in anesthetized mice. In part 3, in vitro myocyte responses to isoproterenol in mice exposed to hindlimb unweighting (HLU) for approximately 2 wk were determined. Heart rate (HR) and mean arterial pressure (MAP) responses to TBCO were measured. In control mice, TBCO increased HR (15 +/- 2 beats/min, P < 0.05) and MAP (17 +/- 2 mmHg, P < 0.05). These responses were markedly potentiated in denervated control (DC) mice, in which the aortic depressor nerve and sympathetic trunk were sectioned before measurement. Baroreflex responses to TBCO were eliminated by blockade with hexamethonium bromide (10 microg/kg). In HLU (denervated) mice, HR and MAP responses were reduced approximately 70% compared with DC mice. In part 2, myocardial contractile responses to TBCO were measured with a left ventricular micromanometer-conductance catheter. TBCO in DC mice increased the slope of the end-systolic pressure-volume relation (end-systolic elastance) by 86 +/- 13%. This inotropic response was attenuated (14 +/- 10%, P < 0.005) after HLU. In part 3, contractile responses to isoproterenol were impaired in myocytes isolated from HLU mice. In conclusion, selective carotid baroreceptor unloading stimulates HR, blood pressure, and myocardial contractility, and HLU attenuates each response. These findings have important implications for the management of OI in astronauts, the elderly, and individuals subjected to prolonged bed rest.
Carboxy terminal region of the Fanconi anemia protein, FANCG/XRCC9, is required for functional activity (2000)

Fanconi anemia (FA) is an autosomal recessive cancer susceptibility syndrome with eight complementation groups. Four of the FA genes have been cloned, and at least three of the encoded proteins, FANCA, FANCC, and FANCG/XRCC9, interact in a nuclear complex, required for the maintenance of normal chromosome stability. In the current study, mutant forms of the FANCA and FANCG proteins have been generated and analyzed with respect to protein complex formation, nuclear translocation, and functional activity. The results demonstrate that the amino terminal two-thirds of FANCG (FANCG amino acids 1-428) binds to the amino terminal nuclear localization signal (NLS) of the FANCA protein. On the basis of 2-hybrid analysis, the FANCA/FANCG binding is a direct protein-protein interaction. Interestingly, a truncated mutant form of the FANCG protein, lacking the carboxy terminus, binds in a complex with FANCA and translocates to the nucleus; however, this mutant protein fails to bind to FANCC and fails to correct the mitomycin C sensitivity of an FA-G cell line. Taken together, these results demonstrate that binding of FANCG to the amino terminal FANCA NLS sequence is necessary but not sufficient for the functional activity of FANCG. Additional amino acid sequences at the carboxy terminus of FANCG are required for the binding of FANCC in the complex. (Blood. 2000;96:1625-1632)
Cancer/testis antigen CAGE mediates Osimertinib Resistance in Non-small cell lung cancer cells and predicts poor Prognosis in Patients with Pulmonary adenocarcinoma (2022)

Abstract Purpose CAGE, a cancer/testis antigen, was originally isolated from the sera of patients with gastric cancers. We have shown the role of CAGE in resistance to chemotherapy and target therapy. In this study, we wanted to investigate the possible role of CAGE in osimertinib, an inhibitor of EGFR tyrosine kinase. Methods The clinicopathological correlation with CAGE and autophagy flux in patients was examined using immunohistochemistry and in situ hybridization. The evaluation of autophagy in osimertinib resistance was analyzed using immune-blot, Immuno-cell chemistry and immuno-histochemistry in vitro and in vivo. Results Here, we found that IHC showed the expression of CAGE in more than 50% of patients with pulmonary adenocarcinomas (pADCs). The expression of CAGE was increased in pADCs after the acquisition of EGFR-TKIs resistance. High expression of CAGE was correlated with shorter overall survival (OS) and progression free survival (PFS) in patients with pADCs. Thus, CAGE mediates osimertinib resistance and predicts poor prognosis in patients with pADCs. Osimertinib-resistant non-small cell lung cancer cells (PC-9/OSI) were established. Mechanistic studies of CAGE-mediated osimertinib resistance were performed. PC-9/OSI cells showed increased autophagic flux and CAGE expression compared with parental sensitive PC-9 cells. PC-9/OSI cells showed higher tumorigenic, metastatic, and angiogenic potential compared with parental PC-9 cells. CAGE CRISPR-Cas9 cell lines showed decreased autophagic flux, invasion, migration potential, and tumorigenic potential compared with PC-9/OSI cells in vitro and in vivo. Conclusion Collectively, our data suggest that CAGE plays a crucial role in the progression of tumorigenesis and metastasis by modulating autophagy. Furthermore, our findings propose the inhibition of CAGE as a potential therapeutic strategy for osimertinib resistance.
Generation of quantum entangled states in nonlinear plasmonic structures and metamaterials (Presentation Recording) (2015)

The practical development of quantum plasmonic circuits incorporating non-classical interference [1] and sources of entangled states calls for a versatile quantum theoretical framework which can fully describe the generation and detection of entangled photons and plasmons. However, majority of the presently used theoretical approaches are typically limited to the toy models assuming loss-less and nondispersive elements or including just a few resonant modes. Here, we present a rigorous Green function approach describing entangled photon-plasmon state generation through spontaneous wave mixing in realistic metal-dielectric nanostructures. Our approach is based on the local Huttner-Barnett quantization scheme [2], which enables problem formulation in terms of a Hermitian Hamiltonian where the losses and dispersion are fully encoded in the electromagnetic Green functions. Hence, the problem can be addressed by the standard quantum mechanical perturbation theory, overcoming mathematical difficulties associated with other quantization schemes. We derive explicit expressions with clear physical meaning for the spatially dependent two-photon detection probability, single-photon detection probability and single-photon density matrix. In the limiting case of low-loss nondispersive waveguides our approach reproduces the previous results [3,4]. Importantly, our technique is far more general and can quantitatively describe generation and detection of spatially-entangled photons in arbitrary metal-dielectric structures taking into account actual losses and dispersion. This is essential to perform the design and optimization of plasmonic structures for generation and control of quantum entangled states. [1] J.S. Fakonas, H. Lee, Y.A. Kelaita and H.A. Atwater, Nature Photonics 8, 317(2014) [2] W. Vogel and D.-G. Welsch, Quantum Optics, Wiley (2006). [3] D.A. Antonosyan, A.S. Solntsev and A.A. Sukhorukov, Phys. Rev. A 90 043845 (2014) [4] L.-G. Helt, J.E. Sipe and M.J. Steel, arXiv: 1407.4219
Dual infection with hepatitis A and E viruses in outbreaks and in sporadic clinical cases: Cuba 1998–2003 (2008)

Viral hepatitis ranks as the fifth cause of morbidity for infectious diseases in Cuba. Epidemics are observed frequently in the population, the hepatitis A virus being the main agent responsible for such epidemics. Previous reports also confirmed the circulation of the hepatitis E virus. From 1998 to 2003, 258 serum samples were collected by the Reference Laboratory on Viral Hepatitis during 33 outbreaks of acute viral hepatitis as well as from 39 sporadic clinical cases. Sera were tested for anti-HAV and anti-HEV IgM by EIA. Overall of the 33 outbreaks studied sera from 12 (36.4%) were positive for anti-HAV IgM only, from 7 (21.2%) were positive for anti-HEV IgM only, and from 14 (42.4%) were positive for antibodies to both viruses. Individually of the 258 sera collected, 137 (53.1%) were positives for anti-HAV IgM, 20 (7.8%) were positives for anti-HEV IgM, 33 (12.8%) were positives for both markers and 68 (26.4%) were negative to both. Of the clinical cases, 4 (10.3%) were positives for anti-HAV IgM, 13 (33.3%) were positives for anti-HEV IgM and 5 (12.8%) were positives for both markers. Seventeen (43.6%) sera were negatives for all viral hepatitis markers available (A-E). A high positivity for HEV was found in outbreaks tested with the kit produced by CIGB. In particular HEV seems to infect individuals of all ages. The results demonstrate the co-circulation of and co-infection with two enterically transmitted viruses; however a higher positivity was observed for anti-HAV than to anti-HEV (53.1% vs. 7.8%) in outbreaks.
Abstract 11005: Influence of High-Degree Atrioventricular Block on 30-Day Clinical Outcome Following Acute Myocardial Infarction in the Drug-Eluting Stent Era: Results From Nation-Wide Registry of Acute Myocardial Infarction (2014)

Introduction: This study was conducted to investigate the prognostic value of high-degree atrioventricular block (HDAVB) among patients with acute myocardial infarction (AMI) treated with DES. Methods: A total of 13,862 patients with AMI, registered in the nation-wide AMI database between January 2005 and June 2013, were analyzed. Second- (Mobitz type I or II) and third-degree atrioventricular block (AVB) were considered as HDAVB in this study. Thirty-day major adverse cardiac events (MACE) including all causes of death, recurrent myocardial infarction, and revascularization were evaluated. Results: Percutaneous coronary intervention with implantation of DES was performed in 89.8% of the patients. HDAVB occurred in 378 patients (2.7%). Thirty-day MACE occurred in 1,144 patients (8.2%). Patients with HDAVB showed worse clinical parameters at initial admission, and the presence of HDAVB was associated with 30-day MACE in univariate analyses. However, the prognostic impact of HDAVB was not significant after adjustment of potential confounders (p = 0.489). Among patients with HDAVB, patients with a culprit in the left anterior descending (LAD) coronary artery had worse clinical outcomes than those of patients with a culprit in the left circumflex or right coronary artery. LAD culprit was a significant risk factor for 30-day MACE even after controlling for confounders (odds ratio, 5.28; 95% confidence interval, 1.22-22.81; p = 0.026). Conclusions: Despite differences in clinical parameters at the initial admission, HDAVB was not an independent risk factor for 30-day MACE in adjusted analyses. However, a LAD culprit was an independent risk factor for 30-day MACE among patients with HDAVB.