gebhart/patrepeval huggingface dataset:
Cell-penetrating Peptides Split into Two Groups Based on Modulation of Intracellular Calcium Concentration (2012)

Cell-penetrating peptides (CPPs) promote the uptake of different cargo molecules, e.g. therapeutic compounds, making the harnessing of CPPs a promising strategy for drug design and delivery. However, the internalization mechanisms of CPPs are still under discussion, and it is not clear how cells compensate the disturbances induced by peptides in the plasma membrane. In this study, we demonstrate that the uptake of various CPPs enhances the intracellular Ca(2+) levels in Jurkat and HeLa cells. The elevated Ca(2+) concentration in turn triggers plasma membrane blebbing, lysosomal exocytosis, and membrane repair response. Our results indicate that CPPs split into two major classes: (i) amphipathic CPPs that modulate the plasma membrane integrity inducing influx of Ca(2+) and activating downstream responses starting from low concentrations; (ii) non-amphipathic CPPs that do not evoke changes at relevant concentrations. Triggering of the membrane repair response may help cells to replace distorted plasma membrane regions and cells can recover from the influx of Ca(2+) if its level is not drastically elevated.
Percutaneous nephroureteral drainage and stenting for postsurgical ureteral leaks (1983)

Five patients with postoperative ureteral fistulae subsequent to surgically created ureteral anastomoses were treated successfully by temporary percutaneous nephroureteral drainage and stenting. Low, constant suction applied to the drainage tubes achieved total urinary diversion, while concomitant ureteral stenting seemed to prevent subsequent stricture formation. The techniques have reduced considerably the morbidity of this particular postoperative complication.
MnO2‐Modified Persistent Luminescence Nanoparticles for Detection and Imaging of Glutathione in Living Cells and In Vivo (2014)

Persistent luminescence nanoparticles (PLNPs) hold great promise for the detection and imaging of biomolecules. Herein, we have demonstrated a novel nanoprobe, based on the manganese dioxide (MnO2 )-modified PLNPs, that can detect and image glutathione in living cells and in vivo. The persistent luminescence of the PLNPs can be efficiently quenched by the MnO2 nanosheets. In the presence of glutathione (GSH), MnO2 was reduced to Mn(2+) and the luminescence of PLNPs can be restored. The persistent luminescence property can allow detection and imaging without external excitation and avoid the background noise originating from the in situ excitation. This strategy can offer a promising platform for detection and imaging of reactive species in living cells or in vivo.
Molecular orbital theory for square-planar metal halide complexes (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular orbital theory for square-planar metal halide complexesHarold Basch and Harry B. GrayCite this: Inorg. Chem. 1967, 6, 2, 365–369Publication Date (Print):February 1, 1967Publication History Published online1 May 2002Published inissue 1 February 1967https://pubs.acs.org/doi/10.1021/ic50048a038https://doi.org/10.1021/ic50048a038research-articleACS PublicationsRequest reuse permissionsArticle Views1011Altmetric-Citations107LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Burst mode carrier synchronization with digital phase-locked loops (2003)

The authors propose a digital phase-locked loop (DPLL) based on stochastic approximation for burst mode synchronization. This loop contains a time-decreasing gain term and provides rapid acquisition and significant noise immunity. An acquisition analysis is presented and shows that the modified loop greatly improves the acquisition performance. The reason that the modified loop performs so well is that the time-varying gain eliminates the hangup anomaly in the DPLL. Architectures are proposed for both a known start of burst and a start of burst with some associated randomness. The performance of these architectures is partially analyzed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The anatomy of a multimodal information filter (2003)

The proliferation of objectionable information on the Internet has reached a level of serious concern. To empower end-users with the choice of blocking undesirable and offensive websites, we propose a multimodal information filter, named MORF. In this paper, we present MORF's core components: its confidence-based classifier, a Cross-bagging ensemble scheme, and multimodal classification algorithm. Empirical studies and initial statistics collected from the MORF filters deployed at sites in the U.S. and Asia show that MORF is both efficient and effective, due to our classification methods.
Polymerization of acrylates and methacrylates to make homopolmers and block copolymers initiated by N‐alkoxyphthalimides and succinimides (1995)

Abstract Various N ‐alkoxyphthalimides were prepared and tested as initiators for polymerization of a variety of monomers. Acrylates and methacrylates polymerized at 40–50°C. Vinyl acetate and styrene were moderately reactive at 60–65°C. Rates of reaction were sensitive to the choice of solvent. THF generally gave the highest conversions, with much reduced reactivities in solvents of higher polarity, such as acetonitrile, acetone, DMSO or DMF. In aliphatic hydrocarbon solvents or di‐ n ‐butyl ether no polymers were obtained. Bulk polymerizations proceeded well, depending on the monomer. Rates of polymerization were sensitive to the structure of the group attached to nitrogen. OR groups, where R contained α‐electron‐withdrawing esters, benzylic or allylic groups, were more reactive than when R was an aliphatic group. A–B block copolymers were readily prepared, starting with PMA, PBA or PMMA. However, because the rates of initiation were slow, relative to rates of propagation, N ‐alkoxyphthalimide initiators survived mostly intact. Consequently, final A–B block copolymers were invariably contaminated with indeterminate amounts of homopolymer from polymerization of the second monomer.
Preliminary results from a parallel MATLAB compiler (2002)

We are developing a compiler that translates ordinary MATLAB scripts into code suitable for compilation and execution on parallel computers supporting C and the MPI message-passing library. We report the speedup achieved for several MATLAB scripts on three diverse parallel architectures: a distributed-memory multicomputer (Meiko CS-2); a symmetric multiprocessor (Sun Enterprise Server 4000); and a cluster of symmetric multiprocessors (Sun SPARCserver 20s). By generating code suitable for execution on parallel computers, our system multiplies the gains achievable by compiling, rather than interpreting, MATLAB scripts. Generating parallel code has an additional advantage: the amount of primary memory available on most parallel computers makes it possible to solve problems too large to solve on a single workstation.
An accurate gate length extraction method for sub-quarter micron MOSFET's (1996)

By comparing measured and simulated gate-to-source/drain capacitances, C/sub gds/, an accurate gate length extraction method is proposed for sub-quarter micron MOSFET's applications. We show that by including the 2-D field effect on the fringing capacitance, the polysilicon depletion and the quantum-well effects in the C/sub gds/ simulation, the polysilicon gate length, L/sub poly/, can be accurately determined for device lengths down to the 0.1 /spl mu/m regime. The accuracy of this method approaches that of cross-sectional TEM on the device under test, but without destroying the device. Furthermore, we note that as a result of accurate L/sub poly/ extraction, the source/drain lateral diffusion length, L/sub diff/, and effective channel length, L/sub eff/, can also be determined precisely. The accuracy of L/sub diff/ is confirmed by examining their consistency with experimentally obtained 2-D source/drain profile.
Hazelnut allergy: from pollen-associated mild allergy to severe anaphylactic reactions (2008)

Sensitization to hazelnut can either be associated with mild oral symptoms, depending on sensitization to pollen, or with more serious allergic symptoms, related to sensitization to homologues of nut and peanut allergens.
Relativistic Charge Form Factor of the Deuteron from (np)-Scattering Phase Shifts (2000)

Relativistic integral representation in terms of experimental neutron-proton scattering phase shifts is used to compute the charge form factor of the deuteron $ G_{Cd}(Q^2)$. The results of numerical calculations of $|G_{Cd}(Q^2)|$ are presented in the interval of the four-momentum transfers squared $0 \leq Q^2 \leq 35 fm^{-2}$. Zero and the prominent secondary maximum in $|G_{Cd}(Q^2)|$ are the direct consequences of the change of sign in the experimental $^3S_1 $- phase shifts. Till the point $Q^2 \simeq 20 fm^{-2}$ the calculated total relativistic correction to $|G_{Cd}(Q^2)|$ is positive and reaches the maximal value of 25% at $Q^2 \simeq 14 fm^{-2}$.
THE SYNTHESIS OF AN OCTAPEPTIDE AMIDE WITH THE HORMONAL ACTIVITY OF OXYTOCIN (1953)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTHE SYNTHESIS OF AN OCTAPEPTIDE AMIDE WITH THE HORMONAL ACTIVITY OF OXYTOCINVincent du Vigneaud, Charlotte Ressler, College John M. Swan, Carleton W. Roberts, Panayotis G. Katsoyannis, and Samuel GordonCite this: J. Am. Chem. Soc. 1953, 75, 19, 4879–4880Publication Date (Print):October 1, 1953Publication History Published online1 May 2002Published inissue 1 October 1953https://pubs.acs.org/doi/10.1021/ja01115a553https://doi.org/10.1021/ja01115a553research-articleACS PublicationsRequest reuse permissionsArticle Views1856Altmetric-Citations464LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
VehiCaching: Embracing User Request on Vehicle Route with Proactive Data Transportation (2015)

Due to the mobile networks experiencing heterogeneity and intricacy, many studies with efficient data off-loading have been considered. In this paper, we address the benefits of deploying movable caching nodes (e.g. mobile users, vehicles), namely VehiCaching (VC), in cellular networks. We classify the role of VC into two issues: 1) considering multiple access schemes between macrocell and VC for fair and aggressive data off-loading (at the user-side), and 2) developing the file placement strategy with the concept of storage range which relates vehicles' route to embracing user request (at the VC-side). Compared with conventional priority-based caching and non-caching cellular networks, we evaluate the performance gains with respect to the average data throughputs versus storage range, outage probabilities versus target data-rate, and probabilistic distributions of outage probability to capture changed environments by mobility.
Cognitive modeling reveals menu search in both random and systematic (1997)

Article Free Access Share on Cognitive modeling reveals menu search in both random and systematic Authors: Anthony J. Hornof Artificial Intelligence Laboratory, Electrical Engineering & Computer Science Department, University of Michigan, 1101 Beal Avenue, Ann Arbor, MI Artificial Intelligence Laboratory, Electrical Engineering & Computer Science Department, University of Michigan, 1101 Beal Avenue, Ann Arbor, MIView Profile , David E. Kieras Artificial Intelligence Laboratory, Electrical Engineering & Computer Science Department, University of Michigan, 1101 Beal Avenue, Ann Arbor, MI Artificial Intelligence Laboratory, Electrical Engineering & Computer Science Department, University of Michigan, 1101 Beal Avenue, Ann Arbor, MIView Profile Authors Info & Claims CHI '97: Proceedings of the ACM SIGCHI Conference on Human factors in computing systemsMarch 1997 Pages 107–114https://doi.org/10.1145/258549.258621Published:27 March 1997Publication History 50citation946DownloadsMetricsTotal Citations50Total Downloads946Last 12 Months35Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Exocrine pancreatic secretion in pigs fed sow's milk and milk replacer, and its relationship to growth performance1 (2007)

The objective of this study was to quantify and compare the effects of sow's milk and 2 milk replacer diets (containing clotting or non-clotting protein sources) on exocrine pancreatic secretion, plasma cholecystokinin, and immunoreactive cationic trypsin in pigs. In addition, the relationship between exocrine pancreatic secretion and growth in milk-fed pigs was studied. In a changeover experiment, 9 chronically catheterized pigs of 6.6 +/- 0.19 kg of BW were studied for 3 wk. Pigs were assigned to each of 3 diets. Exocrine pancreatic secretion was measured from the third to the seventh day on each diet. The protein content and trypsin activity of the pancreatic juice were measured. Blood samples were taken at 10 min before and after milk ingestion and were analyzed for cholecystokinin and immunoreactive cationic trypsin. Pancreatic protein and trypsin secretion did not differ between pigs fed sow's milk and those fed milk replacer, but the volume secreted was less for the pigs fed sow's milk (0.75 vs. 1.03 mL x kg(-1) x h(-1); P < 0.01). A postprandial response to milk intake was not observed. The 2 milk replacer diets did not affect exocrine pancreatic secretion differently. The average exocrine pancreatic secretion (volume, 0.94 mL x kg(-1) x h(-1); protein, 4.28 mg x kg(-1) x h(-1); trypsin, 1.65 U x kg(-1) x h(-1)) was intermediate between literature values for suckling and weaned pigs. Plasma cholecystokinin was elevated (approximately 18 pmol x L(-1)) and showed low correlations with the pancreatic secretion traits. Plasma immunoreactive cationic trypsin was not significantly related to any of the pancreatic secretion traits and should therefore not be used as an indicator for exocrine pancreatic function in milk-fed pigs. Exocrine pancreatic secretion varied substantially among individual pigs (protein, 0.22 to 13.98 mg x kg(-1) x h(-1)). Pancreatic protein and trypsin secretion showed a positive, nonlinear relationship with performance traits. It was concluded that neither specific sow's milk ingredients nor the protein source are responsible for a low pancreatic protein secretion in suckling pigs. Exocrine pancreatic secretion was positively correlated with ADG in pigs at an identical milk intake.
A study of systems for delivering antigens and plasmid DNA for intranasal immunization against tick-borne encephalitis virus. (2002)

Our previous studies indicated the possibility for some neurotropic viruses to spread into the brain of immune animals through the olfactory pathway. Thus, nasal mucosa in the olfactory region is likely to be a promising target for mucosal immunization to protect the CNS from neurotropic viral infections. THE MAIN IDEA OF THE RESEARCH: Intranasal immunization inducing mucosal and systemic immune responses blocks the propagation of neurotropic virus into the brain via the olfactory pathway and neutralizes the multiplication of virus in visceral organs, allowing more effective protection against neurotropic infections transmitted by bloodsucking arthropods to be achieved. Thus, study of the efficiency of delivery systems for intranasal immunization against tick-borne encephalitis (TBE) virus is an urgent task in the development of anti-TBE mucosal vaccine. To study intranasal immunization against TBE virus, we have chosen four delivery systems (DSs), namely, (i) biodegradable microparticles, (ii) cationic liposomes, and live attenuated (iii) bacterial and (iv) viral vectors. The gene of TBE virus protein E was inserted into the pcDNA3 plasmid (designated as pcDNA3/E-TBE). Three types of delivery system for plasmid DNA were developed and studied in vitro. The first system, artificial virus-like microparticles (VLP), consists of polyglycan-spermidine complexes that cover pcDNA3/E-TBE DNA. The second system is cationic liposomes with DNA of the plasmid pcDNA3/E-TBE. The third system is an attenuated Salmonella strain containing pcDNA3/E-TBE. The fourth system is a recombinant vaccinia strain with inserted genes of TBE virus proteins C, prM, E, NS1, NS2a, NS2b, and NS3. The DSs were tested in COS-7 and CV-1 cell lines and macrophages by ELISA of cell lysate. The results obtained showed the expression of the E gene in transfected cells, thereby demonstrating that these DSs are suitable for mucosal immunization. High levels of immune response shifted to the Th1 type were detected in BALB/c mice following intranasal immunization with recombinant vaccinia-TBE strain and VLP-pcDNA3/E-TBE. The mice immunized intranasally with recombinant vaccinia-TBE strains were completely protected against intraperitoneal challenge with TBE virus strain Sofjin, whereas intranasal immunization with killed TBE vaccine failed to induce a significant level of protection.
Parenthood in relation to infertility (1984)

info:eu-repo/semantics/nonPublished
Trace Level Organics in Hydrofluoric Acid Determined by Attenuated Total Internal Reflection Infrared Spectroscopy (1997)

Trace levels of organic impurities in the hydrofluoric acid solutions were measured by a multiple internal reflection infrared spectroscopic (MIRIS) technique. The MIRIS utilizes a clean attenuated total reflection (ATR) silicon crystal to extract organic impurities from the HF solutions. An open beam single-channel background spectrum combined with statistical analysis was used to ensure the reproducibility of absorbed organics measurement. The hydrofluoric acid samples were analyzed under an ultrapure nitrogen blanket to avoid airborne organics interferences. The adsorbed organic contaminants were found to randomly orient on the silicon ATR probe surface. A higher level of organic impurities was found in the more concentrated hydrofluoric acid solutions.
Towards a Cloud-Based Design and Manufacturing Paradigm: Looking Backward, Looking Forward (2012)

The rise of cloud computing is radically changing the way enterprises manage their information technology (IT) assets. Considering the benefits of cloud computing to the information technology sector, we present a review of current research initiatives and applications of the cloud computing paradigm related to product design and manufacturing. In particular, we focus on exploring the potential of utilizing cloud computing for selected aspects of collaborative design, distributed manufacturing, collective innovation, data mining, semantic web technology, and virtualization. In addition, we propose to expand the paradigm of cloud computing to the field of computer-aided design and manufacturing and propose a new concept of cloud-based design and manufacturing (CBDM). Specifically, we (1) propose a comprehensive definition of CBDM; (2) discuss its key characteristics; (3) relate current research in design and manufacture to CBDM; and (4) identify key research issues and future trends.
Signal-specialized parametrization (2002)

To reduce memory requirements for texture mapping a model, we build a surface parametrization specialized to its signal (such as color or normal). Intuitively, we want to allocate more texture samples in regions with greater signal detail. Our approach is to minimize signal approximation error --- the difference between the original surface signal and its reconstruction from the sampled texture. Specifically, our signal-stretch parametrization metric is derived from a Taylor expansion of signal error. For fast evaluation, this metric is pre-integrated over the surface as a metric tensor. We minimize this nonlinear metric using a novel coarse-to-fine hierarchical solver, further accelerated with a fine-to-coarse propagation of the integrated metric tensor. Use of metric tensors permits anisotropic squashing of the parametrization along directions of low signal gradient. Texture area can often be reduced by a factor of 4 for a desired signal accuracy compared to non-specialized parametrizations.
Evaluations of imidazolium ionic liquids as novel skin permeation enhancers for drug transdermal delivery (2016)

In this work, imidazolium ionic liquids (imidazolium ILs) were employed as the novel chemical permeation enhancers (CPEs) and their performances and mechanisms of action were deeply investigated. Testosterone was used as a model drug to investigate the transdermal delivery enhancement of twenty imdidazolium ILs. The results suggested that the promotion activity connected to the structure and composition of the ILs. The quantitative structure-activity relationship (QSAR) model revealed a good linearity between the electronic properties of ILs and their enhancements. Furthermore, the transepidermal water loss (TEWL) and scanning laser confocal microscope (CLSM) examinations showed the strong improvement of ILs on skin barrier permeability, which were well correlated with the drug penetration profiles. The total reflection-Fourier transform infrared spectroscopy (ATR-FTIR) and atomic force microscope (AFM) evaluations of skins indicated that the ILs can disrupt the regular and compact arrangements of the corneocytes, change the surface properties of stratum corneum, and make the skin structure more permeable. Our work demonstrated the significant skin permeation promotion profiles of the imidazolium ILs, which are of great potential in transdermal drug delivery systems.
Principles of cryo-EM single-particle image processing (2015)

Single-particle reconstruction is the process by which 3D density maps are obtained from a set of low-dose cryo-EM images of individual macromolecules. This review considers the fundamental principles of this process and the steps in the overall workflow for single-particle image processing. Also considered are the limits that image signal-to-noise ratio places on resolution and the distinguishing of heterogeneous particle populations.