gebhart/patrepeval huggingface dataset:
Experimental application of controlled limb reperfusion after incomplete ischaemia (1996)

Severe local and systemic complications may occur after revascularization of extremities exposed to prolonged complete or incomplete ischaemia. These complications may be reduced by controlling the reperfusate and the circumstances of the reperfusion period. Ten adult German domestic pigs were exposed to 6 h of incomplete limb ischaemia by occlusion of the left iliac artery. To simulate the clinical situation of embolectomy, the occlusive snares were released after the ischaemic period in five pigs and normal blood flow developed with systemic pressure (uncontrolled reperfusion). In the other five pigs, a controlled reperfusate was delivered at controlled pressure before establishing normal blood reperfusion (controlled reperfusion). At the end of the observation period (90 min after start of reperfusion), the group with controlled reperfusion had a lower mean(s.e.m.) tissue water content (81.8(0.7) versus 84.3(0.7) per cent, P < 0.05, a greater increase in tissue adenosine 5'-triphosphate compared with values at the end of ischaemia (6.2(1.5) versus -2.5(1.8) mumol per g protein, P < 0.03), a higher tissue pH (7.2(0.1) versus 6.8(0.1), P < 0.03), a smaller temperature decrease (0.3(0.2) versus 1.2(0.3) degrees C, P < 0.05), lower concentrations of creatine kinase (355.0(87.5) versus 624.4(73.4) units/l, P < 0.05) and lactate dehydrogenase (LDH) (369.5(42.5) versus 538.4(39.2 units/l, P < 0.03) in the femoral vein blood and lower LDH concentrations (356.5(48.9) versus 546.0(37.8 units/l, P < 0.03) in central venous blood. These data indicate that severe local and systemic damage occurs with uncontrolled (normal blood) reperfusion even after incomplete limb ischaemia, and that these changes can be reduced by delivering a controlled reperfusate under controlled conditions.
Spectral Geometry on Nilmanifolds (1997)

Two Riemannian manifolds are said to be isospectral if the associated Laplace-Beltrami operators have the same spectrum. Riemannian nilmanifolds have provided a rich source of examples of isospectral manifolds, exhibiting a wide variety of different phenomena. In particular, there exist continuous families of isospectral, nonisometric nil-manifolds, isospectral nilmanifolds for which the Laplacians acting on one-forms are not isospectral, and isospectral nilmanifolds that are not even locally isometric. This article reviews three different methods for constructing isospectral nilmanifolds and examines the geometry of resulting examples.
A Comparative Study of Texture Features for the Discrimination of Gastric Polyps in Endoscopic Video (2005)

In this paper, we extend the application of four texture feature extraction methods proposed for the detection of colorectal lesions, into the discrimination of gastric polyps in endoscopic video. Support Vector Machines have been utilized for the texture classification task. The polyp discrimination performance of the surveyed schemes is compared by means of Receiver Operating Characteristics (ROC). The results advocate the feasibility of a computer-based system for polyp detection in video gastroscopy that exploits the textural characteristics of the gastric mucosa in conjunction with its color appearance.
Formation of hydroxyl groups in plasma-polymerized N-vinyl-2-pyrrolidone by reduction with sodium borohydride (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFormation of hydroxyl groups in plasma-polymerized N-vinyl-2-pyrrolidone by reduction with sodium borohydrideDingsheng Yu and Roger E. MarchantCite this: Macromolecules 1989, 22, 7, 2957–2961Publication Date (Print):July 1, 1989Publication History Published online1 May 2002Published inissue 1 July 1989https://pubs.acs.org/doi/10.1021/ma00197a014https://doi.org/10.1021/ma00197a014research-articleACS PublicationsRequest reuse permissionsArticle Views128Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Soy (Glycine max)-Derived Phospholipids Exhibit Potent Anti-Apoptotic Activity (1998)

We have isolated and identified a soybean phospholipid mixture from unroasted soy (Glycine max) flour that is a potent inhibitor of apoptotic cell death. This phospholipid mixture has been purified from several soy derived materials including soy flour, soy molasses, and crude commercial soy lecithin. Analysis of this bioactive lipid mixture has identified the two major constituents as phosphatidic acid and phosphatidylinositol. This lipid mixture also contains lesser amounts of lysophosphatidic acid, lysophosphatidylinositol, and lysophosphatidylcholine. These phospholipids contain the typical distribution of fatty acids found in soy, predominantly C16:0 and C18:2 (hexadecanoic and 9,12–octadecadienoic) in a 60:40 to 50:50 ratio. Less than 10% of other varieties of fatty acids were identified; the most common other fatty acids found were C18:0, C18:1 and C18:3. Apoptosis inhibition was assessed following serum deprivation of a mouse embryonic stem cell line (C3H–10T1/2). This anti-apoptotic bioassay was used to monitor the purification of the bioactive phospholipid mixture. Of the phospholipids contained in the mixture, lysophosphatidic acid was found to be the most potent inhibitor of apoptotic cell death. The anti-apoptotic factor described here is distinct from the bioactive, well characterized estrogen-like, anti-cancer factor and the Bowman–Birk protease inhibitor, neither of which possess anti-apoptotic activity in this assay.
RE-Doped Ternary Sulfides ALnS2 (A = Rb, K, Na; Ln = La, Gd, Lu, Y) - a New Phosphor Family (2015)

We have recently started to investigate structural, scintillation, luminescence and paramagnetic (in case of Eu 2+ doping) properties of the unexplored family of rare earth (RE)-doped ternary sulfides of general formula ALnS 2 (A = Rb, K, Na; Ln = La, Gd, Lu, Y), which show prospective application potential in the field of X-ray and solid state white LED phosphors. The X-ray diffraction (XRD) detected only a single crystalline phase of rhombohedral lattice system, except NaLaS 2 which has cubic structure. Time-resolved luminescence spectroscopy, XRD and electron paramagnetic resonance were employed to understand the nature of Eu 2+ emission centre in these sulfidic hosts and find correlation between structural and optical properties of these materials. Eu 2+ and Ce 3+ emission features are investigated in a broad temperature and concentration ranges and phenomenological modeling and delayed recombination decay measurements are used to understand better the Eu 2+ excited state dynamics. Optical properties of ALnS 2 doped by another RE ions are presented as well. Motivating figure 1 shows clear energy shift of the Eu 2+ emission spectra maxima with different chemical compositions, peaking from 498 nm (RbLuS 2 ) to 779 nm (NaGdS 2 ). Figure 1. RT Radioluminescence spectra of Eu 2+ -doped ALnS 2 .
A Comparison of Recombinant Urokinase with Vascular Surgery as Initial Treatment for Acute Arterial Occlusion of the Legs (1998)

Despite its association with a higher frequency of hemorrhagic complications, intraarterial infusion of urokinase reduced the need for open surgical procedures, with no significantly increased risk of amputation or death.
Quando devemos fazer a manutenção ou substituir os equipamentos fotoativadores? (2021)

Após escolher nossos equipamentos fotoativadores, com base em tudo o que já foi discutido nesta coluna, devemos nos atentar à manutenção e à possível necessidade de substituição desses equipamentos. Os equipamentos fotoativadores possuem diferentes características, e alguns deles emitem luz de forma mais homogênea e com uma emitância mais adequada para a polimerização de materiais resinosos , mas essas características precisam se manter ao longo do tempo.
Cobalt Hemoglobin: pH Dependence of Adair Constants and the Bohr Effects (1978)

Precise oxygen equilibrium curves have been obtained for cobalt hemoglobin at pH values from 5.5 to 8.2. The Hill plots are symmetric having asymptotes with slopes of unity. At pH 7.0, cobalt hemoglobin has p0.5= 116 torr (15.45 kPa), pm= 117 torr (15.58 kPa) and a Hill coefficient of n= 1.72. The values of n decrease slightly with either decrease or increase of pH; the protein is almost non-cooperative at pH ≥ 8.2. The Adair constants have been calculated with a non-linear least-squares program. From δInpm/δpH a maximum of 2.5 Bohr protons was calculated at physio- logical pH values. The majority of alkaline Bohr protons are released after binding of the first and the third oxygen with maxima at pH 7.6 and 7.3, respectively. The acid Bohr effect was also observed with the majority of the protons taken up following the first and third oxygen bound. Smaller alkaline Bohr effects were obtained by differential titration and at higher pH than that calculated from oxygen equilibria. The discrepancy can be largely attributed to the binding of salt components to cobalt hemoglobin.
[Glomerulopathy associated with glomerular microtubular deposits: a report of a case]. (1992)

A male aged 58 was admitted to our hospital because of proteinuria, hematuria and bilateral pretibial edema. Laboratory tests showed normocytic, normochromic anemia and moderately impaired renal function. Antinuclear antibodies were negative. Neither M-protein nor Bence-Jones protein were detected. Light microscopic study on the biopsied renal specimen indicated a moderate mesangial proliferation accompanying with the deposition of PAS-positive and Congo red-negative materials in the subendothelial area. C3 accumulated segmentally along the capillary walls, which was clarified by immunofluorescence microscopy. Staining for IgG, IgA, IgM and light chains were negative. Electron microscopy demonstrated the deposition of microtubules in the mesangial, subepithelial and subendothelial areas. The diameter of these microtubules ranged from 40 to 80 nm. Such type of the microtubules have been reported to exist in the glomeruli in the patients with systemic diseases such as amyloidosis, systemic lupus erythematosus, cryoglobulinemia and light chain disease. In our patient, however, any clinical or serological findings suggestive of these systemic diseases were not obtained. On the other hand previous report pointed out that microtubules deposited in the glomeruli in the patients with immunotactoid glomerulopathy or other glomerulopathies. Our patient had the clinical features consistent with these glomerulopathies. However, no depositions of immunoglobulins were observed. This case is an atypical glomerulopathy accompanying with the glomerular microtubular deposits.
Case 30-2011 (2011)

A 62-year-old woman with autoimmune overlap syndrome and polymyositis presented to this hospital with anemia, thrombocytopenia, and acute renal failure. Four days before admission, she was found on the floor of her home, confused and minimally conversant.
Immunologic Response to Fungus is not Universally Associated with Rhinosinusitis (2009)

In contrast to previously reported data, IL-5 responses to Alternaria extract were not predictive of CRS presence. Our results in patients from Utah and Texas significantly differ from previously published findings in predominantly Midwestern patients. The immunologic response to fungal extracts appears to be heterogenous and may differ based on geography, allergy status, and/or other as-yet unknown factors.
Regio- and Chemoselective Bromination of 2,3-Diarylcyclopent-2-en-1-ones (2012)

The bromination of 2,3-diarylcyclopent-2-en-1-ones under various conditions has been studied. It was found that depending on the brominating reagent and nature of solvent the bromine atom can be introduced at the 4- or 5-position of the ethene "bridge", as well as into the aryl moieties. Aryl group bromination is accomplished with such reagents as molecular bromine, N-bromosuccinimide, or tetrabutylammonium tribromide. 5-Bromocyclopentenones with very high efficiency can be obtained by the reaction with copper(II) bromide in methanol, while 4-bromoketones are prepared in n-propyl acetate. The developed methods can be highly useful for the synthesis of bromo-substituted 2-cyclopenten-1-ones and their close analogues, which are important synthons in organic synthesis and for the preparation of a variety of useful substances.
Energy-efficient ConvNets through approximate computing (2016)

Recently convolutional neural networks (ConvNets) have come up as state-of-the-art classification and detection algorithms, achieving near-human performance in visual detection. However, ConvNet algorithms are typically very computation and memory intensive. In order to be able to embed ConvNet-based classification into wearable platforms and embedded systems such as smartphones or ubiquitous electronics for the internet-of-things, their energy consumption should be reduced drastically. This paper proposes methods based on approximate computing to reduce energy consumption in state-of-the-art ConvNet accelerators. By combining techniques both at the system- and circuit level, we can gain energy in the systems arithmetic: up to 30× without losing classification accuracy and more than 100× at 99% classification accuracy, compared to the commonly used 16-bit fixed point number format.
Using mouse models to explore genotype–phenotype relationship in Down syndrome (2007)

Down Syndrome (DS) caused by trisomy 21 is characterized by a variety of phenotypes and involves multiple organs. Sequencing of human chromosome 21 (HSA21) and subsequently of its orthologues on mouse chromosome 16 have created an unprecedented opportunity to explore the complex relationship between various DS phenotypes and the extra copy of approximately 300 genes on HSA21. Advances in genetics together with the ability to generate genetically well-defined mouse models have been instrumental in understanding the relationships between genotype and phenotype in DS. Indeed, elucidation of these relationships will play an important role in understanding the pathophysiological basis of this disorder and helping to develop therapeutic interventions. A successful example of using such a strategy is our recent studies exploring the relationship between failed nerve growth factor (NGF) transport and amyloid precursor protein (App) overexpression. We found that increased dosage of the gene for App is linked to failed NGF signaling and cholinergic neurodegeneration in a mouse model of DS. Herein, we discuss several mouse models of DS and explore the emergence of exciting new insights into genotype-phenotype relationships, particularly those related to nervous system abnormalities. An important conclusion is that uncovering these relationships is enhanced by working from carefully defined phenotypes to the genes responsible.
Full length cloning and phylogenetic analyses of TCTP and ferritin genes from Fenneropenaeus indicus (H. Milne Edwards) (2014)

Elucidation of bacterial afflictions in commercially important aquaculture reared shrimps through molecular analyses is pivotal for prevention and/or control of disease outbreaks. In this study we examined the phylogenetic relatedness and compared the possible immune related functional roles of both translationally controlled tumor protein (TCTP) and ferritin genes with the previous studies. Both of them were substantially upregulated in the Indian white prawn Fenneropenaeus indicus postlarvae due to bath challenging with a virulent strain, Vibrio harveyi D3. Full-length cloning of these genes by RACE-PCR yielded 727 bp long TCTP and 1212 bp long ferritin gene sequences. Their open reading frame was 507 bp and 510 bp respectively. The TCTP ORF coded for 168 amino acids with three substitutions at positions 37, 141, 155, and ferritin ORF coded for 170 amino acids with no species specific substitutions. Phylogenetic analysis suggested the closest relatedness of both TCTP and ferritin from F. indicus to F. chinensis. In addition to reporting the full length sequences of these immune relevant genes, this study is useful to recognize their conserved natures which perhaps make them important defense related proteins in the innate immune system of F. indicus.
Integratomics of Human Dermal Fibroblasts Treated with Low Molecular Weight Hyaluronic Acid (2021)

Hyaluronic acid (HA) is a glycosaminoglycan very common in commercial products from pharmaceuticals to cosmetics due to its widespread distribution in humans and its diversified physico-chemical proprieties. Despite its extended use and preliminary evidence showing even also opposite activities to the native form, the precise cellular effects of HA at low-molecular-weight (LWM-HA) are currently unclear. The 'omics sciences currently in development offer a new and combined perspective on the cellular and organismal environment. This work aims to integrate lipidomics analyses to our previous quantitative proteomics one for a multi-omics vision of intra- and extra-cellular impact of different concentrations (0.125, 0.25, and 0.50%) of LMW-HA (20-50 kDa) on normal human dermal fibroblasts by LC-high resolution mass spectrometry (LC-HRMS). Untargeted lipidomics allowed us to identify 903 unique lipids mostly represented by triacylglycerols, ceramides, and phosphatidylcholines. According to proteomics analyses, LMW-HA 0.50% was the most effective concentration also in the lipidome rearrangement especially stimulating the synthesis of ceramides involved in skin hydration and reparation, cell signaling, and energy balance. Finally, integrative analyses showed 25 nodes covering several intra- and extra-cellular functions. The more complete comprehension of intra- and extra-cellular effects of LMW-HA here pointed out will be useful to further exploit its features and improve current formulations even though further studies on lipids biosynthesis and degradation are necessary.
Resonant recognition model and protein topography (1991)

This study describes the further extension of the resonant recognition model for the analysis and prediction of protein--protein and protein--DNA structure/function dependencies. The model is based on the significant correlation between spectra of numerical presentations of the amino acid or nucleotide sequences of proteins and their coded biological activity. According to this physico-mathematical method, it is possible to define amino acids in the sequence which are predicted to be the most critical for protein function. Using sperm whale myoglobin, human hemoglobin and hen egg white lysozyme as model protein examples, sets of predicted amino acids, or so-called 'hot spots', have been identified within the tertiary structure. It was found for each protein that the predicted 'hot spots', which are distributed along the primary sequence, are spatially grouped in a dome-like arrangement over the active site. The identified amino acids did not correspond to the amino acid residues which are involved in the chemical reaction site of these proteins. It is thus proposed that the resonant recognition model helps to identify amino acid residues which are important for the creation of the molecular structure around the catalytic active site and also the associated physical field conditions required for biorecognition, docking of the specific substrate and full biological activity.
An automatic method to discriminate malignant masses from normal tissue in digital mammograms1 (2000)

Specificity levels of automatic mass detection methods in mammography are generally rather low, because suspicious looking normal tissue is often hard to discriminate from real malignant masses. In this work a number of features were defined that are related to image characteristics that radiologists use to discriminate real lesions from normal tissue. An artificial neural network was used to map the computed features to a measure of suspiciousness for each region that was found suspicious by a mass detection method. Two data sets were used to test the method. The first set of 72 malignant cases (132 films) was a consecutive series taken from the Nijmegen screening programme, 208 normal films were added to improve the estimation of the specificity of the method. The second set was part of the new DDSM data set from the University of South Florida. A total of 193 cases (772 films) with 372 annotated malignancies was used. The measure of suspiciousness that was computed using the image characteristics was successful in discriminating tumours from false positive detections. Approximately 75% of all cancers were detected in at least one view at a specificity level of 0.1 false positive per image.
Even more practical secure logging: Tree-based Seekable Sequential Key Generators. (2014)

Abstract. Computer log files constitute a precious resource for system administrators for discov-ering and comprehending security breaches. A prerequisite of any meaningful log analysis is that attempts of intruders to cover their traces by modifying log entries are thwarted by storing them in a tamper-resistant manner. Some solutions employ cryptographic authentication when storing log entries locally, and let the authentication scheme’s property of forward security ensure that the cryptographic keys in place at the time of intrusion cannot be used to manipulate past log entries without detection. This strong notion of security is typically achieved through frequent updates of the authentication keys via hash chains. However, as security demands that key updates take place rather often (ideally, at a resolution of milliseconds), in many settings this method quickly reaches the limits of practicality. Indeed, a log auditor aiming at verifying a specific log record might have to compute millions of hash iterations before recovering the correct verification key. This problem was addressed only recently by the introduction of seekable sequential key genera-tors (SSKG). Every instance of this cryptographic primitive produces a forward-secure sequence of symmetric (authentication) keys, but also offers an explicit fast-forward functionality. The only currently known SSKG construction replaces traditional hash chains by the iterated evaluation of