gebhart/patrepeval huggingface dataset:
Transdisciplinary Translational Science for Youth Health and Wellness: Introduction to a Special Issue (2021)

Abstract Background Transdisciplinary translational science applies interdisciplinary approaches to the generation of novel concepts, theories and methods involving collaborations among academic and non-academic partners, in order to advance the translation of science into broader community practice. Objective This paper introduces a special issue on transdisciplinary translational science for youth health and wellness. We provide an overview of relevant research paradigms, share the related goals of the Iowa State University Translational Research Network (U-TuRN), and introduce the specific papers in the issue. Method Authors were asked to submit empirical reports, programmatic reviews or policy-related papers that examined youth health issues from a transdisciplinary translational perspective. Results The papers included in this special issue each involve direct and fully-integrated community-university partnerships and collaborations between academic and non-academic partners in scholarship and research. Reports emphasize the value of the applied nature of the work with a research agenda driven primarily by real-world health and social needs. Conclusions There is growing acceptance of the need for transdisciplinary, community-university collaborative research approaches as a means to meet both the requirements posed by real-world problems as well as goals of advancing scientific knowledge and innovation. In this issue, readers will find papers that show the promise of rethinking existing conceptual frameworks to incorporate transdisciplinary approaches as a catalyst to addressing translational science questions related to the field of children and youth care.
Overmolded plastic pad array carriers (OMPAC): a low cost, high interconnect density IC packaging solution for consumer and industrial electronics (2002)

A novel surface mount leadless semiconductor packaging technology, OMPAC, has been developed to meet the requirements of next-generation portable electronic products. Benefits of OMPAC compared to convenient surface mount leaded plastic packages such as plastic leaded chip carriers and quad flat packs, include smaller size, higher package interconnect density, higher test and solder assembly yields due to the use of pre-applied solder bumps, and greater technology extendability in the areas of high-speed integrated circuits, multichip modules and fine pitch soldering. Component-level qualification of OMPAC was successfully completed using industry standard environmental tests. C-mode scanning acoustical microscopy was extensively used to optimize package design and processing.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
High performance visualization of time-varying volume data over a wide-area network status (2000)

This paper presents an end-to-end, low-cost solution for visualizing time-varying volume data rendered on a parallel computer located at a remote site. Pipelining and careful grouping of processors are used to hide I/O time and to maximize processor utilization. Compression is used to significantly cut down the cost of transferring output images from the parallel computer to a display device through a wide-area network. This complete rendering pipeline makes possible highly efficient rendering and remote viewing of high-resolution time-varying data sets in the absence of high-speed network and parallel I/O support. To study the performance of this rendering pipeline and to demonstrate high-performance remote visualization, tests were conducted on a PC cluster in Japan as well as an SGI Origin 2000 operated at the NASA Ames Research Center with the display located at UC Davis.
Color measurement methods and systems in printing technology and graphic arts. (1993)

This article explains the importance and use of the color control technique -- on the basis of colormetrics -- for the complete production line in order to produce economically high-quality multicolor prints. For this purpose, first a short survey on the printing technologies and on prepress is given with special consideration to the digital technique. On this basis, the quality of multicolor prints is explained and specified. The principles of colormetrics are only treated to the extent which is necessary for understanding the color control techniques and their measurement devices. Color control devices and systems, which are used in practice, are indicated. A detailed description is given of a special scanning spectrometer, how it is used in the printing technique and how it has been evaluated for pointing the way for quality measurement and control techniques for graphical products and systems. Special emphasis is put on the fundamental theoretical model for conversion of color values to production control settings. In summary, the colormetrics and color control techniques are presented as fundamental tools and components for the development of `color management systems,' as they are absolutely necessary for the calibration of several devices within the production line and for system integration.
On Heuristic Method of PE Teaching (2004)

The article analyses and compares the heuristic teaching method and traditional instilling method. The result of the comparison shows that the heuristic method is more applicable in PE teaching and also more practical than traditional instilling method.
Increase in met-enkephalin level and antinociceptive effects induced by kelatorphan in the rat spinal cord. (1986)

Kelatorphan, a mixed inhibitor of "enkephalinases" is used for demonstrating the implication of endogenous enkephalins in nociceptive transmission at the spinal level.
Calcium Transport by Plasma Membranes from a Glucose-Responsive Rat Insulinoma* (1991)

Inside-out plasma membrane vesicles from a glucose-responsive rat insulinoma showed an ATP- and Mg2(+)-dependent uptake of Ca2+. The Km (concentration giving half-maximal activity) for Ca2+ was 60 nM. In the presence of 0.4 microM free Ca2+, the Km for ATP was 15 microM, and the Km for Mg2+ was 4 microM. Glucose (30 mM) decreased Ca2+ uptake by 50%, while other insulin secretagogues had no effect, except for glyceraldehyde, which stimulated Ca2+ uptake. Calmodulin increased the uptake of Ca2+, while trifluoperazine and vanadate inhibited the uptake. The Ca2(+)- and Mg2(+)-dependent ATPase from this tumor has a 10- to 20-fold higher requirement for Ca2+, which suggests that this enzyme is not responsible for Ca2+ transport, rather, Ca2+ transport activity represents only a small fraction of the total Ca2(+)-ATPase activity. The physiological importance of Ca2+ transport in insulin secretion is evident from the inhibition of Ca2+ uptake by glucose, which leads to a decrease in Ca2+ efflux from the cell. This inhibition would lead to an increase in intracellular free Ca2+ and insulin release.
Evaluation of oven controlled crystal oscillator performance under non-continuous stressed operating conditions (2002)

The frequency stability of a set of six oven controlled crystal oscillators has been measured under noncontinuous and other stressed operating conditions. The oscillators were subjected to a range of environmental conditions which would be experienced in an airborne communications terminal. A database, corresponding to those measurements, was generated for support of a Kalman Filter/Neural Network modeling and training effort. The tests were performed at a MITRE environmental control laboratory utilizing a vibration table which was enclosed within a heating chamber. An automated measurement system was used for control and data logging. Initial observations of the test results indicate that non-continuous operation in a benign environment has no noticeable impact on the aging characteristics, while aging under stress is harder to discern from frequency measurements made under composite environmental stress conditions. More elusive are the infrequent but sudden and permanent changes in frequency that appear to occur at random. The magnitude of those frequency jumps was often significant, and justifies further investigation.
ChemInform Abstract: EASY ISOMERIZATION OF A METALLOCYCLOBUTANE COMPLEX, AND ITS RELEVANCE TO THE MECHANISM OF OLEFIN METATHESIS (1976)

Abstract Aus dem Platin‐Komplex (I) und Phenylcyclopropan (II) entsteht der Komplex (III), der bei Behandlung mit Pyridin zunächst den Komplex (V) liefert.
Suicide Bereavement and Social Relationships: A New Application of Durkheim (2022)

Abstract Purpose: The author seeks to identify how suicide-bereaved individuals conceptualize their relationships with deceased loved ones. The author engages Durkheim’s theory of suicide to provide a new framework to analyze this population. Methodology: The author uses qualitative research and coding methods to produce a secondary analysis of previously collected interview transcripts. Findings: The author concludes that participants experience the suicide of a loved one as a social event, conceptualizing it similarly to how Durkheim defined his four suicide types – characterized by too much or too little regulation and/or integration. Research Limitations: As a result of the secondary analysis, a lack of demographic information remains the largest limitation, and the available demographic information indicates the participant population is not a diverse one. Therefore, the larger analysis is limited. Practical and Social Implications: This work provides potential ways to improve current prevention and postvention practices for both the suicide-bereaved and those struggling with suicidality. Subsequently, it may help to improve the health outcomes of these groups. Originality: To the author’s current knowledge, this is the first published use of Durkheim’s Suicide (1897/1966) as a framework to directly examine the suicide-bereaved population in this way. Thus, this work contributes to suicidology and sociology more broadly in two ways: by providing a new way to understand and ultimately help a vulnerable population and by providing a new use of a classic theory.
Multiple-Input Neural Network-Based Residual Echo Suppression (2018)

A residual echo suppressor (RES) aims to suppress the residual echo in the output of an acoustic echo canceler (AEC). Spectral-based RES approaches typically estimate the magnitude spectra of the near-end speech and the residual echo from a single input, that is either the far-end speech or the echo computed by the AEC, and derive the RES filter coefficients accordingly. These single inputs do not always suffice to discriminate the near-end speech from the remaining echo. In this paper, we propose a neural network-based approach that directly estimates the RES filter coefficients from multiple inputs, including the AEC output, the far-end speech, and/or the echo computed by the AEC. We evaluate our system on real recordings of acoustic echo and near-end speech acquired in various situations with a smart speaker. We compare it to two single-input spectral-based approaches in terms of echo reduction and near-end speech distortion.
Automated Segmentation and Registration Methods in Carotid Artery Atherosclerosis Plaque Features and Stenosis (2023)

<em>Carotid artery atherosclerosis plaque characterization, vascular stenosis measurement by use of noninvasive magnetic resonance imaging method is emerging as ideal modality for the evaluation of vascular disease and therapy monitoring. With this aim, in this paper, the topic of carotid artery Magnetic Resonance Imaging (MRI) is discussed with emphasis of segmentation and registration physical principles, techniques in current practice for acquisition and display of vascular anatomy as well as plaque measurement. Main techniques are described for segmentation by: 1.parametric deformable models, 2. feature contour map, contrast enhancement methods; and registration by: 1.edge-detection, 2.feature based, 3.gray level correction, 4.multimodal registration. Later, recent examples are illustrated for carotid artery segmentation, contrast enhancements and carotid artery bifurcation registration algorithms and applications with emphasis of spatial transformation and image reconstruction. Authors indicate the scope of carotid bifurcation tissue analysis to understand and explore deep learning of diagnostic accuracy features.</em>
Probing semiconductor interfacial carrier dynamics through time-resolving the photo-induced electric fields (Conference Presentation) (2017)

Isolating spectral signatures and/or the carrier dynamics that are specific to semiconductor junctions and not just the interface or bulk is challenging. Junctions that form between a semiconductor surface and a contacting layer are the key to their function. Equilibration of chemical potential at such junctions creates an internal electric field and establishes a region where mobile charges are driven away (depletion region). Absorption of light produces electrons and holes within the depletion region where the charges are separated. We developed transient photoreflectance (TPR) as an innovative time-resolved spectroscopic probe that can directly monitor carrier dynamics within and across such junctions. In the TPR method, the change in reflectance (&Delta;R) of a broadband probe from a specific interface is monitored as a function of pump-probe delay. The spectral nature of the reflected beam provides quantitative information about the built-in field; thus, TPR is a non-contact probe of the electric field at that interface. We applied TPR to study charge transfer at p-type gallium-indium phosphide (p-GaInP2) and n-type gallium-arsenide (n-GaAs) interfaces. We monitored the formation and decay of transient electric fields that form upon photoexcitation within bare p-GaInP2, p-GaInP2/platinum (Pt), and p-GaInP2/amorphous titania (TiO2) interfaces. A field at both the p-GaInP2/Pt and p-GaInP2/TiO2 interfaces forms that drives charge separation, however, recombination at the p-GaInP2/TiO2 interface is significantly reduced compared the p-GaInP2/Pt interface. On the other hand, n-GaAs forms an ohmic contact with TiO2 while only a small field forms at the n- GaAs/NiO interface that promotes hole transfer to nickel oxide (NiO).
Abstract C131: HSP27 is necessary in cells showing oncogene hyper-activation. (2013)

Abstract The small heat shock protein of 27 KDa (HSP27) encoded by the HSPB1 gene, is a molecular chaperone with anti-aggregation property, it participates in sequestering damaged proteins, and is involved in the proteasomal degradation of certain proteins under stress conditions. Besides its role in stressed condition, HSP27 plays crucial roles within the cell under unstressed conditions and it provides cytoskeletal structural stability and exerts important anti-apoptotic function by binding apoptotic proteins. Clinically, Hsp27 is highly expressed in many cancers including breast, ovarian and prostate carcinomas and is associated with aggressive tumor behaviour, metastasis, poor prognosis and resistance to chemotherapeutics. Using LV driven expression of HSP27 specific shRNA, HSP27 suppression in three gastric cancer cell lines (GTL-16, MKN-45 and EBC-1) showing addiction to MET because of MET gene amplification was able to induce cell death. Moreover, HSP27 silencing synergized in inducing apoptosis with the MET inhibitor JNJ-38877605, which alone was only able to induce cell cycle blockade. Similarly, (H3255) lung carcinoma and (DiFi) colorectal carcinoma cell lines which carry EGFR amplification and are susceptible to EGFR inhibition were exquisitely susceptible to HSP27 silencing, that induced cell death. HSP27 silenced in twenty human colorectal (CRC) cell lines with either wt KRAS or harbouring KRAS mutations (SW620, LS513, LS1034) or BRAF mutations (OXCO-1, COLO741, COLO-201, COLO-205), Among them the LS513 and LS1034 cells and the COLO-201 and COLO-205, addicted to KRAS and BRAF, respectively, came out to be also addicted to HSP27, as they undergo apoptosis by HSP27 silencing. Taken together, these data suggest that cells addicted to oncogene over-activation require HSP27 for survival and that HSP27 interferes with the effectiveness of targeted agents. Due to its involvement in cancer development, the inhibition of HSP27 has been proposed as a potential cancer treatment strategy. Antisense and peptide aptamer strategies have shown that targeting HSP27 increases cancer cell death in vitro and in vivo in preclinical models. More important, an antisense drug inhibiting HSP27 is available for human therapy and is ongoing Phase II clinical trials. Therefore, HSP27 knockdown in combination with targeted therapies can be envisaged as a viable therapeutic approach for clinical application. Citation Information: Mol Cancer Ther 2013;12(11 Suppl):C131. Citation Format: Johndavid Konda, Martina Olivero, Daniele Musiani, Simona Lamba, Alberto Bardelli, Federica Di Nicolantonio, Maria Flavia Di Renzo. HSP27 is necessary in cells showing oncogene hyper-activation. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2013 Oct 19-23; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2013;12(11 Suppl):Abstract nr C131.
Integration of Patient Specific MRI Imaging Data Into a Stochastic Low-Grade Glioma Model (2013)

A method to validate a previously developed multi-scale stochastic tumor model using patient specific quantitative MRI images is developed. For a specific clinical low-grade glioma case, model parameters are extracted from MRI, an extrapolation of the spatio-temporal evolution is computed and the result compared to the actual tumor development available in another MRI image. The model describes qualitatively and quantitatively avascular tumor growth and its typical structure. The growth rate (radial velocity) of the computed tumor is found to be constant as it is in the clinical case. However, growth rate values differ significantly.
Pathogenic cysteine mutations affect progranulin function and production of mature granulins (2009)

Frontotemporal dementia with ubiquitin-positive inclusions (FTLD-U) can be caused by mutations in the progranulin gene (GRN). Progranulin (PGRN) is a cysteine-rich growth factor, which is proteolytically cleaved by elastase to produce several granulins (GRNs). All FTLD-U mutations in GRN characterized to date result in reduced secreted PGRN protein. We recently reported a Spanish family with progressive non-fluent aphasia and dementia in which a novel C521Y mutation segregates with disease. A second cysteine mutation (C139R) has also been reported to be disease specific. Allele-specific mRNA expression assays in brain reveal that the C521Y mutant allele is expressed at similar levels to the wild-type allele. Furthermore, plasma PGRN levels in C521Y carriers are comparable with non-carrier family relatives, suggesting that the mutation does not affect PGRN protein expression and secretion in vivo. Despite normal PGRN levels C521Y and C139R mutant GRNs show reduced neurite growth-stimulating activity in vitro. Further study revealed that these mutations also cause impaired cleavage of PGRN by elastase. Our data suggest that these mutations affect the function of full-length PGRN as well as elastase cleavage of PGRN into GRNs, leading to neurodegeneration.
Hydraulic modeling of thermal outfall diffusers for the San Onofre nuclear power plant (1974)

Various hydraulic model tests were performed in connection with the design and performance of the offshore thermal outfalls for the San Onofre Nuclear Generating Station (jointly owned by the Southern California Edison Company and the San Diego Gas and Electric Company)near San Clemente, California. These include model investigations of: (i) the multiple port discharges for the proposed Units 2 and 3, (ii) the existing submerged single outlet from Unit 1, (iii) the discharge of heated water from the Units 2 and 3 intakes during heat treatment, and (iv) hydraulic characteristics of discharge ports. On the basis of these investigations, the diffusion structure for each of the proposed new units was designed to be 2500 feet long aligned perpendicular to shore. The diffuser for Unit 3 will extend from 3500 to 6000 feet from shore, and that for Unit 2 from 6000 to 8500 feet from shore. Each diffuser will have 63 discharge nozzles aimed offshore (±25° from the pipe axis, 20° above horizontal). The momentum of the discharge produces and offshore drift of the diluted warm-water plume. The maximum temperature rise on the surface caused by the discharge was found to decrease with increasing longshore current speed, and the discharge momentum from the jets was effective in preventing significant re-entrainment in the event of reversing or low currents. Although the California thermal discharge requirements specify a maximum surface temperature increase of 4°F (beyond 1000 feet from the discharge structure), the laboratory target maximum was established at 2.5°F, to account for possible model-prototype differences and unmodeled effects. The hydraulic model studies showed that the proposed outfall design meets the laboratory target value for a variety of possible longshore current conditions; therefore, it is predicted that the prototype outfall operation will meet the California thermal discharge requirements.
Employing DDBPSK in Optical Burst Switched Systems to Enhance Throughput (2013)

We demonstrate that doubly differential decoding can demodulate phase shift keyed data much faster after the switching event of a tunable laser than usual mth power single differential decoding. This technique can significantly improve throughput of optical burst switched networks.
Cell Surface Estrogen Receptor Alpha Is Upregulated during Subchronic Metabolic Stress and Inhibits Neuronal Cell Degeneration (2012)

In addition to the classical nuclear estrogen receptor, the expression of non-nuclear estrogen receptors localized to the cell surface membrane (mER) has recently been demonstrated. Estrogen and its receptors have been implicated in the development or progression of numerous neurodegenerative disorders. Furthermore, the pathogenesis of these diseases has been associated with disturbances of two key cellular programs: apoptosis and autophagy. An excess of apoptosis or a defect in autophagy has been implicated in neurodegeneration. The aim of this study was to clarify the role of ER in determining neuronal cell fate and the possible implication of these receptors in regulating either apoptosis or autophagy. The human neuronal cell line SH-SY5Y and mouse neuronal cells in primary culture were thus exposed to chronic minimal peroxide treatment (CMP), a form of subcytotoxic minimal chronic stress previously that mimics multiple aspects of long-term cell stress and represents a limited molecular proxy for neurodegenerative processes. We actually found that either E2 or E2-bovine serum albumin construct (E2BSA, i.e. a non-permeant form of E2) was capable of modulating intracellular cell signals and regulating cell survival and death. In particular, under CMP, the up-regulation of mERα, but not mERβ, was associated with functional signals (ERK phosphorylation and p38 dephosphorylation) compatible with autophagic cytoprotection triggering and leading to cell survival. The mERα trafficking appeared to be independent of the microfilament system cytoskeletal network but was seemingly associated with microtubular apparatus network, i.e., to MAP2 molecular chaperone. Importantly, antioxidant treatments, administration of siRNA to ERα, or the presence of antagonist of ERα hindered these events. These results support that the surface expression of mERα plays a pivotal role in determining cell fate, and that ligand-induced activation of mER signalling exerts a powerful cell-survival signal. These results shed new light on the pathogenetic mechanisms leading to neuronal cell degeneration.