gebhart/patrepeval huggingface dataset:
Acute Hypomagnesaemia Complicating the Treatment of Meconium Ileus Equivalent in Cystic Fibrosis (1988)

Meconium ileus equivalent (MIE) is a common and often recurrent complication in adolescent and adult patients with cystic fibrosis (CF). MIE is characterized by partial or complete bowel obstruction, resulting from abnormally viscid mucofaeculant material in the terminal ileum and right colon. Patients present with recurrent abdominal pain, intestinal obstruction, and/or a palpable faecal mass. Conventional treatment consists of the oral and rectal administration of the mucolytic agent N-acetylcysteine, and hypertonic solutions of sodium diatrizoate. We describe the occurrence of acute decreases in plasma magnesium in all of seven patients treated with this regimen with marked hypomagnesaemia (less than 0.70 mmol/l) in four of the seven patients. No changes in plasma sodium, potassium, or calcium were observed.
CCL OSA: a CORBA-based open service access system (2006)

Open Service Access (OSA) is a flexible and efficient approach for mobile service creation and deployment. OSA allows network operators and enterprises to increase revenues via third party applications and service providers. In OSA, network functionality offered to applications is defined by a set of Service Capability Features (SCF). Services can be implemented by applications accessing the Service Capability (SC) through the standardised OSA Application Programming Interface (API). This paper designs and develops a Common Object Request Broker Architecture (CORBA) based OSA system. We show how OSA API interfaces and functions can be implemented by CORBA clients, stubs, servants and skeletons and how CORBA POA and ORB are set up for our OSA implementation. Then we use the authentication procedure for initial access to illustrate how CORBA mechanism works for our OSA implementation.
High Speed F-N Operated Volatile Memory Cell with Stacked Plasma Enhanced Chemical Vapor Deposition (PECVD) Nanocrystalline Si Layer Structure (1998)

A volatile memory structure with nanocrystalline Si (nc-Si) layer and auxiliary floating polysilicon gate is proposed. The charges are injected through tunnel oxide and nc-Si layer by Fowler-Nordheim (F-N) tunneling and then stored in the stacked structure. The nc-Si layer improves programming speed during F-N operation and the extended structure with floating gate improves the limited charge storage volume and makes the memory device with distinct threshold voltage window. The reliability of this cell is shown to be sufficient for using as dynamic memory.
Efficacy and safety of sotagliflozin in patients with type 2 diabetes and stage 3 chronic kidney disease (2023)

After 26 weeks, HbA1c was significantly reduced with sotagliflozin 400 but not 200 mg compared with placebo in this CKD3 cohort. UACR in patients with at least A2 albuminuria was reduced with each of the two doses at 26 weeks, but changes were not sustained at week 52. The safety findings were consistent with previous reports (NCT03242252).
RETINAL DETACHMENT IN MORNING GLORY SYNDROME TREATED BY TRIAMCINOLONE ACETONIDE–ASSISTED PARS PLANA VITRECTOMY (2003)

MATSUMOTO, HIROYOSHI MD; ENAIDA, HIROSHI MD; HISATOMI, TOSHIO MD; UENO, AKIFUMI MD; NAKAMURA, TAKAO MD; YAMANAKA, ICHIRO MD; SAKAMOTO, TAIJI MD; ISHIBASHI, TATSURO MD Author Information
Variables in the determination of mercury by cold vapor atomic absorption (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVariables in the determination of mercury by cold vapor atomic absorptionS. R. Koirtyohann and Moheb. KhalilCite this: Anal. Chem. 1976, 48, 1, 136–139Publication Date (Print):January 1, 1976Publication History Published online1 May 2002Published inissue 1 January 1976https://pubs.acs.org/doi/10.1021/ac60365a020https://doi.org/10.1021/ac60365a020research-articleACS PublicationsRequest reuse permissionsArticle Views102Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Obesity‐induced diabetes and lower urinary tract fibrosis promote urinary voiding dysfunction in a mouse model (2013)

Taken together, these studies suggest that obesity, T2DM, lower urinary tract fibrosis, and urinary voiding dysfunction are inextricably and biologically linked.
Molecular Cloning and In Vitro Expression of a cDNA Clone for Human Cellular Tumor Antigen p53 (1985)

Three clones for the human tumor antigen p53 were isolated from a cDNA library prepared from A431 cells. One of these clones, pR4-2, contains the entire coding region for human p53. This clone directs the synthesis of a polypeptide with the correct molecular weight and immunological epitopes of an authentic p53 molecule in an in vitro transcription-translation reaction. Although the pR4-2 clone contains the coding region for p53, it is not a full-length copy of the human p53 mRNA. Northern analysis showed that the p53 mRNA is approximately 2,500 nucleotides long, whereas the pR4-2 insert is only 1,760 base pairs in length. Analysis of the DNA sequence of this clone suggests that the human p53 polypeptide has 393 amino acids. We compared the predicted amino acid sequence of the pR4-2 clone with similar clones for the mouse p53 and found long regions of amino acid homology between these two molecules.
Wafer-Scale Bi-Assisted Semi-Auto Dry Transfer and Fabrication of High-Performance Monolayer CVD WS2 Transistor (2022)

A novel wafer-scale semi-automated dry transfer process for monolayer (1L) CVD WS <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> was developed utilizing the weakly coupled interface between semimetal (Bi) and two-dimensional (2D) semiconductor (WS <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> ). Bi semimetal serves as a gently adhesive transfer template for 2D materials, introducing minimal additional defects during the transfer process. Based on 2D materials processed using this new transfer method, semimetal-contacted (Bi and Sb) monolayer CVD WS <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> nFETs were further demonstrated at wafer scale. Our CVD 1L WS <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> nFETs fabricated using semimetal-assisted transfer with semimetal (Bi and Sb) contacts show record high on-current of 250 µA/µm and 243 µA/µm at V <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DS</inf> = 1 V, and record low contact resistance of 0.63 kΩ•µm and 0.73 kΩ•µm, respectively.
STREET FURNITURE IN CUMBERNAULD NEW TOWN (1980)

The article considers the subject of street furniture, its choice and siting. In the case of a new town such as cumbernauld, the choice of street furniture should follow A design theme. Problems of equipment design and location are examined in the following sections - bus stops, street lighting, road and footpath signing and landscaping. It is concluded that from the range of well designed equipment available such as shelters, lighting units, signs and barriers, items must be selected and sited to form a visually attractive and useful street environment. (TRRL)
Spatial variation of the current in grain boundary Josephson junctions (2000)

The spatial variation of the current across the boundary in several YBa2Cu3O7−x grain boundary Josephson junctions was determined using direct methods. A phase retrieval algorithm was used to calculate the positional critical current density J(x) from critical current versus applied magnetic field, Ic(B), measurements. The current distributions were highly nonuniform along the length of the junctions. These measurements are consistent with existing filamentary grain boundary models, low temperature scanning microscopy studies, and laser scanning microscopy studies of high Tc grain boundaries. The very large scatter in the critical currents reported in the literature for grain boundaries of the same macroscopic geometry appear to be due to the underlying variations in local critical currents.
The effects of MyD88 deficiency on disease phenotype in dysferlin‐deficient A/J mice: role of endogenous TLR ligands (2013)

An absence of dysferlin leads to activation of innate immune receptors such as Toll-like receptors (TLRs) and skeletal muscle inflammation. Myeloid differentiation primary response gene 88 (MyD88) is a key mediator of TLR-dependent innate immune signalling. We hypothesized that endogenous TLR ligands released from the leaking dysferlin-deficient muscle fibres engage TLRs on muscle and immune cells and contribute to disease progression. To test this hypothesis, we generated and characterized dysferlin and MyD88 double-deficient mice. Double-deficient mice exhibited improved body weight, grip strength, and maximum muscle contractile force at 6-8 months of age when compared to MyD88-sufficient, dysferlin-deficient A/J mice. Double-deficient mice also showed a decrease in total fibre number, which contributed to the observed increase in the number of central nuclei/fibres. These results indicate that there was less regeneration in the double-deficient mice. We next tested the hypothesis that endogenous ligands, such as single-stranded ribonucleic acids (ssRNAs), released from damaged muscle cells bind to TLR-7/8 and perpetuate the disease progression. We found that injection of ssRNA into the skeletal muscle of pre-symptomatic mice (2 months old) resulted in a significant increase in degenerative fibres, inflammation, and regenerating fibres in A/J mice. In contrast, characteristic histological features were significantly decreased in double-deficient mice. These data point to a clear role for the TLR pathway in the pathogenesis of dysferlin deficiency and suggest that TLR-7/8 antagonists may have therapeutic value in this disease.
Studies of Tumor Suppressor Genes via Chromosome Engineering (2015)

The development and progression of malignant tumors likely result from consecutive accumulation of genetic alterations, including dysfunctional tumor suppressor genes. However, the signaling mechanisms that underlie the development of tumors have not yet been completely elucidated. Discovery of novel tumor-related genes plays a crucial role in our understanding of the development and progression of malignant tumors. Chromosome engineering technology based on microcell-mediated chromosome transfer (MMCT) is an effective approach for identification of tumor suppressor genes. The studies have revealed at least five tumor suppression effects. The discovery of novel tumor suppressor genes provide greater understanding of the complex signaling pathways that underlie the development and progression of malignant tumors. These advances are being exploited to develop targeted drugs and new biological therapies for cancer.
[Proliferation inhibiting and apoptosis inducing effects of parthenolide on human multiple myeloma cells]. (2006)

This first report of anti-proliferation and apoptosis induction effects of PTL on MM cells shows that able to significantly inhibit the proliferation and induce the apoptosis of MM cells and enhance the caspase-3 activity, PTL may be a potentially useful drug for treatment of MM.
Dual effects of increased glycogen synthase kinase-3β activity on adult neurogenesis (2012)

Adult neurogenesis, the generation of new neurons during the adulthood, is a process controlled by several kinases and phosphatases among which GSK3β exerts important functions. This protein is particularly abundant in the central nervous system, and its activity deregulation is believed to play a key role in chronic disorders such as Alzheimer's disease. Previously, we reported that in vivo overexpression of GSK3β (Tet/GSK3β mice) causes alterations in adult neurogenesis, leading to a depletion of the neurogenic niches. Here, we have further characterized those alterations, finding a delay in the switching-off of doublecortin marker as well as changes in the survival and death rates of immature precursors and a decrease in the total number of mature neurons. Besides, we have highlighted the importance of the inflammatory environment, identifying eotaxin as a possible modulator of the detrimental effects on adult neurogenesis. Taking advantage of the conditional system, we have also explored whether these negative consequences of increasing GSK3 activity are susceptible to revert after doxycycline treatment. We show that transgene shutdown in symptomatic mice reverts microgliosis, abnormal eotaxin levels as well as the aforementioned alterations concerning immature neurons. Unexpectedly, the decrease in the number of mature neurons and neuronal precursor cells of the subgranular zone of Tet/GSK3β mice could not be reverted. Thus, alterations in adult neurogenesis and likely in neurodegenerative disorders can be restored in part, although neurogenic niche depletion represents a non-reversible damage persisting during lifetime with a remarkable impact in adult mature neurons.
Plant genomics: from weed to wheat (2013)

A report on the first 'Plant Genomics Congress' meeting, held in London, UK, 12-13 May 2013.
Analyses of rat Pneumocystis carinii antigens recognized by human and rat antibodies by using western immunoblotting (1986)

The major Pneumocystis carinii antigens inducing antibody responses in infected hosts were identified by Western immunoblotting techniques. The biochemical nature of these antigens was also elucidated. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis followed by protein staining revealed a major component with a molecular weight (MW) of greater than 205,000. This major component disappeared and a new major protein staining component of approximately 110,000 to 116,000 MW appeared when electrophoresis was done in the presence of beta-mercaptoethanol. Periodic acid-Schiff staining revealed that this major component contains carbohydrate moieties. A major component in the 55,000- to 60,000-MW region was visible with periodic acid-Schiff stain, but not with a protein stain, after electrophoresis in the presence of beta-mercaptoethanol. The majority of sera tested from humans with diagnosed pneumocystosis and from rats allowed to recover from steroid-induced pneumocystosis reacted strongly with 110,000- to 116,000-, and 55,000- to 60,000-MW components. These sera often, but not always, detected antigens with MWs of approximately 170,000, 125,000, and 30,000 to 32,000. The data suggest that the antigenic composition of P. carinii is relatively complex and that rat and human P. carinii probably share antigenic determinants. Competitive studies between infection-derived human and rat antisera for the major rat P. carinii components revealed competition; rat antisera appeared to recognize a greater range of antigenic epitopes than did human antisera. Protease treatment of the antigenic components that had been immobilized on nitrocellulose paper destroyed their antigenic reactivity with rat antibody. Treatment with sodium periodate decreased reactivity of this 110,000- to 116,000-MW component and completely destroyed the reactivity of the 55,000- to 60,000-MW component with rat antibody.
Expression of mage genes by non‐small‐cell lung carcinomas (1994)

Human gene MAGE-I codes for an antigen that is recognized on melanoma cells by autologous cytolytic T lymphocytes (CTL). This antigen is potentially useful as a target for cancer immunotherapy because gene MAGE-I is not expressed in any normal tissues except the testis. We tested 46 surgical samples of non-small-cell lung carcinomas and observed MAGE-I expression in 16 of them (35%). Genes MAGE-2 and 3, which are closely related to MAGE-I, were expressed by a similar proportion of these tumors. Some small-cell lung tumors also express MAGE genes. The proportion of tumors expressing MAGE-I suggests that lung tumor patients may constitute the largest group of patients potentially eligible for pilot studies involving MAGE-I immunization.
Renormalization-group theory for the propagation of a turbulent burst (1992)

We consider the propagation of a plane front separating a turbulent region of fluid from a quiescent region. Initially, the turbulent-energy distribution as a function of z, the displacement normal to the front, is assumed to be localized, and after a time t, general renormalization-group arguments show that there is a similarity solution of the form q(z,t)\ensuremath{\sim}${\mathit{t}}^{\mathrm{\ensuremath{-}}(2/3+2\mathrm{\ensuremath{\alpha}}\mathrm{\ifmmode \tilde{}\else \~{}\fi{}})}$f (${\mathit{zt}}^{\mathrm{\ensuremath{-}}(2/3+\mathrm{\ensuremath{\beta}})}$, \ensuremath{\epsilon}), where \ensuremath{\alpha}\ifmmode \tilde{}\else \~{}\fi{} and \ensuremath{\beta} are \ensuremath{\epsilon}-dependent anomalous dimensions, satisfying the scaling law \ensuremath{\alpha}\ifmmode \tilde{}\else \~{}\fi{}+\ensuremath{\beta}=0 and \ensuremath{\epsilon} is a measure of the dissipation. Using perturbation theory, we calculate values of \ensuremath{\alpha}\ifmmode \tilde{}\else \~{}\fi{} and \ensuremath{\beta} to O(\ensuremath{\epsilon}), which are in good agreement with numerical calculations, and we explicitly verify the above scaling law and find the form of the scaling function f.
Online quantitative monitoring of live cell engineered cartilage growth using diffuse fiber-optic Raman spectroscopy (2017)

Tissue engineering (TE) has the potential to improve the outcome for patients with osteoarthritis (OA). The successful clinical translation of this technique as part of a therapy requires the ability to measure extracellular matrix (ECM) production of engineered tissues in vitro, in order to ensure quality control and improve the likelihood of tissue survival upon implantation. Conventional techniques for assessing the ECM content of engineered cartilage, such as biochemical assays and histological staining are inherently destructive. Raman spectroscopy, on the other hand, represents a non-invasive technique for in situ biochemical characterization. Here, we outline current roadblocks in translational Raman spectroscopy in TE and introduce a comprehensive workflow designed to non-destructively monitor and quantify ECM biomolecules in large (>3 mm), live cell TE constructs online. Diffuse near-infrared fiber-optic Raman spectra were measured from live cell cartilaginous TE constructs over a 56-day culturing period. We developed a multivariate curve resolution model that enabled quantitative biochemical analysis of the TE constructs. Raman spectroscopy was able to non-invasively quantify the ECM components and showed an excellent correlation with biochemical assays for measurement of collagen (R<sup>2</sup> = 0.84) and glycosaminoglycans (GAGs) (R<sup>2</sup> = 0.86). We further demonstrated the robustness of this technique for online prospective analysis of live cell TE constructs. The fiber-optic Raman spectroscopy strategy developed in this work offers the ability to non-destructively monitor construct growth online and can be adapted to a broad range of TE applications in regenerative medicine toward controlled clinical translation.
Practices of PLDI (2014)

column Practices of PLDI Authors: Hans Boehm View Profile , Jack Davidson View Profile , Kathleen Fisher View Profile , Cormac Flanagan View Profile , Jeremy Gibbons View Profile , Mary Hall View Profile , Graham Hutton View Profile , David Padua View Profile , Frank Tip View Profile , Jan Vitek View Profile , Philip Wadler View Profile Authors Info & Claims ACM SIGPLAN NoticesVolume 49Issue 4SApril 2014 pp 33–38https://doi.org/10.1145/2641638.2641649Published:01 July 2014Publication History 0citation30DownloadsMetricsTotal Citations0Total Downloads30Last 12 Months1Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Spacecraft Doppler tracking: Noise budget and accuracy achievable in precision radio science observations (2005)

We discuss noise in Doppler tracking of deep space probes and provide a detailed noise model for Doppler radio science experiments. The most sensitive current experiments achieve fractional frequency fluctuation noise of about 3 × 10 −15 at 1000‐s integration time, corresponding to better than 1 micron per second velocity noise. Our noise model focuses primarily on the Fourier range ≈10 −4 –1 Hz, but we briefly discuss noise in lower‐frequency observations. We indicate applications of the noise model to experiment planning, identify phenomena limiting current Doppler sensitivity, and discuss the prospects for significant sensitivity improvements.
Threshold and rate equation considerations for a H&lt;sup&gt;+&lt;/sup&gt;-Cs charge-exchange laser (1976)

A VUV lasing scheme employing charge-exchange between H+ ions and Cs atoms is discussed. An approximate set of rate equations is described and numerically solved to determine the conditions under which the threshold for laser action might be achieved. The requited density and sharpness of both the H+ and Cs pulses and the expected characteristics of the laser output under various initial conditions are determined from the solution of these equations.
Resistive gas sensor with integrated MOSFET micro hot-plate based on an analogue SOI CMOS process (2003)

This paper describes the characterisation of a new type of integrated gas sensors. These gas sensors are fully CMOS compatible and offer ultra low power consumption. MOSFET micro-heaters are created within the device silicon on an SOI wafer, which elevate the substrate temperature through self-heating. A membrane is formed by the removal of the handle silicon by a DRIE process. Electrical and thermal characterisations have been performed showing operating temperatures in excess of 220/spl deg/C are possible for a power consumption of less than 80 mW. The resistive gas sensor is then formed by the low-temperature CVD of a metal oxide film over a pair of gold electrodes. The utilization of CMOS technology permits the fabrication of high-temperature gas sensors at low-cost, high reproducibility, and higher sensitivity with on-chip circuit integration. This makes these smart SOI sensors suitable for a range of battery-operated, hand-held gas monitors and electronic noses.