gebhart/patrepeval huggingface dataset:
Autoantibodies Against Ro/SS-A, CENP-B, and La/SS-B are Increased in Patients with Kidney Allograft Antibody-Mediated Rejection (2020)

ABSTRACT Antibody-mediated rejection (AMR) causes &gt;50% of late kidney graft losses. Although donor-specific antibodies (DSA) against HLA cause AMR, antibodies against non-HLA antigens are also linked to rejection. Identifying key non-HLA antibodies will improve our understanding of antibody-mediated injury. We analyzed non-HLA antibodies using protein microarrays in sera from 91 kidney transplant patients with AMR, mixed rejection, acute cellular rejection (ACR), or acute tubular necrosis (ATN). IgM and IgG antibodies against 134 non-HLA antigens were measured pre-transplant, at the time of biopsy-proven diagnosis, and post-diagnosis. Findings were validated in 60 kidney transplant patients from an independent cohort. Seventeen non-HLA antibodies were significantly increased (p&lt;0.05) in AMR and mixed rejection compared to ACR or ATN pre-transplant, nine at diagnosis and six post-diagnosis. AMR and mixed cases showed significantly increased pre-transplant levels of IgG anti-Ro/SS-A and anti-CENP-B, compared to ACR. Together with IgM anti-CENP-B and anti-La/SS-B, these antibodies were also significantly increased in AMR/mixed rejection at diagnosis. Increased IgG anti-Ro/SS-A and anti-CENP-B pre-transplant and at diagnosis, and IgM anti-La/SS-B at diagnosis, were associated with the presence of microvascular lesions, but not with tubulitis or interstitial/total inflammation. All three antibodies were associated with the presence of class-II DSA (p&lt;0.05). Significantly increased IgG anti-Ro/SS-A in AMR/mixed compared to ACR (p=0.01), and numerically increased IgM anti-CENP-B (p=0.05) and anti-La/SS-B (p=0.06), were validated in the independent cohort. This is the first study that implicates autoantibodies against Ro/SS-A and CENP-B in AMR. These non-HLA antibodies may participate in the crosstalk between autoimmunity and alloimmunity in kidney AMR. SIGNIFICANCE STATEMENT Antibody-mediated rejection (AMR) causes &gt;50% of kidney graft losses. Although donor-specific antibodies against HLA cause AMR, antibodies against non-HLA antigens are also linked to rejection. Serum samples of 91 kidney transplant patients were analyzed using protein arrays against 134 non-HLA antigens. AMR and mixed rejection cases showed significantly increased pre-transplant levels of IgG anti-Ro/SS-A and anti-CENP-B, compared to acute cellular rejection. Together with IgM anti-CENP-B and anti-La/SS-B, these antibodies were significantly increased in AMR/mixed rejection at diagnosis and were validated in a second, independent cohort. Increased IgG anti-Ro/SS-A, IgG anti-CENP-B and IgM anti-La/SS-B were associated with the presence of microvascular lesions and anti-HLA class-II antibodies. This is the first study to implicate anti-Ro/SS-A, anti-La/SS-B and anti-CENP-B autoantibodies in AMR.
DEVELOPMENT OF THE PARENTAL WORRIES OF RECURRENT ABDOMINAL PAIN QUESTIONNAIRE (2003)

s Submitted for the 68th Annual Scientific Meeting of the American College of Gastroenterology October 10-15, 2003, Baltimore, Maryland: FUNCTIONAL BOWEL SYNDROME: PDF Only
Scaling Up In-Memory-Computing Classifiers via Boosted Feature Subsets in Banked Architectures (2018)

In-memory computing is an emerging approach for overcoming memory-accessing bottlenecks, by eliminating the costs of explicitly moving data from point of storage to point of computation outside the array. However, computation increases the dynamic range of signals, such that performing it via the existing structure of dense memory substantially squeezes the signalto-noise ratio (SNR). In this brief, we explore how computations can be scaled up, to jointly optimize energy/latency/bandwidth gains with SNR requirements. We employ algorithmic techniques to decompose computations so that they can be mapped to multiple parallel memory banks operating at chosen optimal points. Specifically focusing on in-memory classification, we consider a custom IC in 130-nm CMOS IC and demonstrate an algorithm combining error-adaptive classifier boosting and multi-armed bandits, to enable segmentation of a feature vector into multiple subsets. The measured performance of 10-way MNIST digit classification, using images downsampled to 16×16 pixels (mapped across four separate banks), is 91%, close to that simulated using full unsegmented feature vectors. The energy per classification is 879.7 pJ, 14.3× lower than that of a system based on separated memory and digital accelerator.
LEF-1 drives aberrant β-catenin nuclear localization in myeloid leukemia cells (2019)

Canonical Wnt/β-catenin signaling is frequently dysregulated in myeloid leukemias and is implicated in leukemogenesis. Nuclear-localized β-catenin is indicative of active Wnt signaling and is frequently observed in acute myeloid leukemia (AML) patients; however, some patients exhibit little or no nuclear β-catenin even where cytosolic β-catenin is abundant. Control of the subcellular localization of β-catenin therefore represents an additional mechanism regulating Wnt signaling in hematopoietic cells. To investigate the factors mediating the nuclear-localization of β-catenin, we carried out the first nuclear/cytoplasmic proteomic analysis of the β-catenin interactome in myeloid leukemia cells and identified putative novel β-catenin interactors. Comparison of interacting factors between Wnt-responsive cells (high nuclear β-catenin) <i>versus</i> Wnt-unresponsive cells (low nuclear β-catenin) suggested the transcriptional partner, LEF-1, could direct the nuclear-localization of β-catenin. The relative levels of nuclear LEF-1 and β-catenin were tightly correlated in both cell lines and in primary AML blasts. Furthermore, LEF-1 knockdown perturbed β-catenin nuclear-localization and transcriptional activation in Wnt-responsive cells. Conversely, LEF-1 overexpression was able to promote both nuclear-localization and β-catenin-dependent transcriptional responses in previously Wnt-unresponsive cells. This is the first β-catenin interactome study in hematopoietic cells and reveals LEF-1 as a mediator of nuclear β- catenin level in human myeloid leukemia.
Osteoblast and Osteoclast Crosstalks: From OAF to Ephrin (2012)

The maintenance of bone homeostasis is tightly controlled, and largely dependent upon cellular communication between osteoclasts and osteoblasts, and the coupling of bone resorption to bone formation. This tight coupling is essential for the correct function and maintenance of the skeletal system, repairing microscopic skeletal damage and replacing aged bone. Cells in osteoclast and osteoblast lineages communicate with each other through diffusible paracrine factors, cell-cell contact, and cell-bone matrix interaction. Osteoclast-osteoblast communication occurs in a basic multicellular unit (BMU) at the initiation, transition and termination phases of bone remodeling. At the initiation phase, hematopoietic precursors are recruited to the BMU. These precursors differentiate into osteoclasts following interactions with osteoblasts, which express and/or secrete ligands as RANK-L and OPG. Subsequently, the transition from bone resorption to formation is mediated by osteoclast-derived 'coupling factors', which direct the differentiation and activation of osteoblasts in resorbed lacunae to refill it with new bone. Signals derived from molecules released from the resorbed bone matrix, as TGF-beta and bidirectional signaling generated by interaction between ephrinB2 on osteoclasts and EphB4 on osteoblast precursors facilitates the transition. At the termination phase, bone remodeling is completed by osteoblastic bone formation and mineralization of bone matrix. The research steps that brought to the present knowledge are summarized in this review.
Clinical review: extracorporeal blood purification in severe sepsis. (2003)

Sepsis and septic shock are the leading causes of acute renal failure, multiple organ system dysfunction, and death in the intensive care unit. The pathogenesis of sepsis is complex and comprises a mosaic of interconnected pathways. Several attempts to improve patient outcomes by targeting specific components of this network have been unsuccessful. For these reasons, the ideal immunomodulating strategy would be one that restores immunologic stability rather than blindly inhibiting or stimulating one or another component of this complex network. Hence, the recent focus of immunomodulatory therapy in sepsis has shifted to nonspecific methods of influencing the entire inflammatory response without suppressing it. Here, we discuss the various modalities of extracorporeal blood purification, the existing evidence, and future prospects.
Restaurant Managers’ Adoption of Sustainable Practices: An Application of Institutional Theory and Theory of Planned Behavior (2017)

The restaurant industry uses vast amounts of resources, but only a paucity of research discusses sustainability issues from restaurant management point of views. By applying both institutional theory and theory of planned behavior, this study addresses this gap by asking casual restaurant managers what motivates them to adopt and implement sustainable practices and by examining managers’ behaviors when facing environmental pressures. The study revealed restaurant managers were most influenced by pressures from their suppliers, customers and to a lesser extent from their employees and by expectations of society at large. Future research should investigate a nationwide sample of restaurant managers.
Detecting Black Hole Attacks in Tactical MANETs using Topology Graphs (2007)

Black hole attacks are a serious threat to communication in tactical MANETs. In this work we present TOGBAD a new centralised approach, using topology graphs to identify nodes attempting to create a black hole. We use well-established techniques to gain knowledge about the network topology and use this knowledge to perform plausibility checks of the routing information propagated by the nodes in the network. We consider a node generating fake routing information as malicious. Therefore, we trigger an alarm if the plausibility check fails. Furthermore, we present promising first simulation results. With our new approach, it is possible to already detect the attempt to create a black hole before the actual impact occurs.
A comparison of the clinical effect between e-PTFE membrane-tube implant and Ahmed glaucoma valve implant for the treatment of refractory glaucoma (2003)

In order to compare the clinical efficacy of expanded polytetrafluoroethylene membrane-tube implant (MT implant) and Ahmed implant in the treatment of refractory glaucoma, the medical records of the patients who had been followed-up for more than 1 year after glaucoma implant surgery were reviewed retrospectively. Either MT or Ahmed implants were selected randomly and implanted by one surgeon in patients with refractory glaucoma. There was no significant difference in clinical variables such as age, intraocular pressure and ocular surgery history between the MT implant and Ahmed implant groups (n = 20 eyes of 19 patients in each group) before surgery. The course of change in intraocular pressure and the number of anti-glaucoma medications were not significantly different between the 2 groups during the entire study period (p > 0.1). Kaplan-Meier analysis for intraocular pressure control between 6 and 21 mmHg showed 90% and 95% at 6 months, and 85% and 85% at 12 months, in the MT and Ahmed groups, respectively (p = 0.982). A few self-limiting complications, all within the first month after surgery, were noted in each group. In this study, MT implant showed comparable results to Ahmed implant. MT implant may be useful as a good substitute for other currently used implants without any loss in efficacy or increase in risk, and with potential advantage coming from its soft consistency and small volume.
SIMPLEs [DataSet]: a single-cell RNA sequencing imputation strategy preserving gene modules and cell clusters variation (2020)

A main challenge in analyzing single-cell RNA sequencing (scRNASeq) data is to reduce technical variations yet retain cell heterogeneity. Due to low mRNAs content per cell and molecule losses during the experiment (called “dropout”), the gene expression matrix has substantial zero read counts. Existing imputation methods either treat each cell or each gene identically and independently, which oversimplifies the gene correlation and cell type structure. We propose a statistical model-based approach, called SIMPLEs, which iteratively identifies correlated gene modules and cell clusters and imputes dropouts customized for individual gene module and cell type. Simultaneously, it quantifies the uncertainty of imputation and cell clustering. Optionally, SIMPLEs can integrate bulk RNASeq data for estimating dropout rates. In simulations, SIMPLEs performed significantly better than prevailing scRNASeq imputation methods by various metrics. By applying SIMPLEs to several real data sets, we discovered gene modules that can further classify subtypes of cells. Our imputations successfully recovered the expression trends of marker genes in stem cell differentiation and can discover putative pathways regulating biological processes.
Effectiveness of Counseling-Based Adult Group Aural Rehabilitation Programs: A Systematic Review of the Evidence (2005)

A systematic evidence-based review was conducted to examine the effectiveness of counseling and communication strategy-oriented group adult aural rehabilitation (AR) programs. The literature search for relevant articles focused on studies that (1) employed adults with hearing impairment; (2) used a group aural rehabilitation program that emphasized counseling and communication strategies; (3) utilized a randomized controlled trial, quasi-experimental, or non-intervention cohort design; (4) employed an outcome measure that assessed some aspect of personal adjustment, perceived hearing handicap, or hearing aid benefit and/or satisfaction; and (5) were published in a refereed journal. Twelve articles were found that met these inclusion criteria. Analysis of the 12 studies led to the following conclusion: there is reasonably good evidence that participation in an adult AR program provides short-term reduction in self-perception of hearing handicap and potentially better use of communication strategies and hearing aids. It is less clear whether this advantage over provision of hearing aids alone persists over time.
Studies on Antitussives. II (1960)

Antitussive activity of several opium alkaloids and their N-oxides was examined and the general pharmacological properties were studied of codeine N-oxide which is the most potent compound among them.Employing the two methods of assay for antitussive activity*1, it was found that codeine N-oxide possessed greater antitussive activity than codeine phosphate, whereas it was very weak in analgesic activity against pressure pain in mice. Furthermore, it was found that its acitons on blood pressure, respiration and heart, and its acute toxicity were definitely weaker than those of codeine phosphate.The constipating action and inhibition of gastrointestinal propulsion of codeine N-oxide were found to be less than those of codeine phosphate.
Single-dose Sertaconazole Vaginal Tablet Treatment of Vulvovaginal Candidiasis (2006)

Single-dose sertaconazole proved to be a more convenient and symptom-relieving treatment for VVC. The advantages of such management are worthy of further study in women with relapse VVC.
Doing Deals in Disheveled Deregulating Markets (2002)

Parties contemplating power-asset purchase and sale deals need to take into account the disheveled state of regulation in the current environment that has the potential to create institutional transactional barriers and obscure transaction valuation as well. Because the measuring rods for the significance of evolving legal/regulatory requirements are time, cost, and possible long-term impediment to success, the key issues are: 1) Which regulators are in charge? 2) Have the standards that these regulators apply in the approval process remained constant? 3) Are the applicable standards consistent and clear in formulation? The safe approach appears to be to assume FERC9s reluctance to permit a transaction with the potential of marginal pricing power, to develop financing whose credit support does not depend on parent cross-subsidies, to evaluate all pricing on both MBR (market-based-rate) and non-MBR pricing assumptions, and to simplify corporate capital structures.
Causality-Based Criteria for a Negative Refractive Index Must Be Used With Care (2008)

Using the principle of causality as expressed in the Kramers-Kronig relations, we derive a generalized criterion for a negative refractive index that admits imperfect transparency at an observation frequency omega. It also allows us to relate the global properties of the loss (i.e., its frequency response) to its local behavior at omega. However, causality-based criteria rely on the group velocity, not the Poynting vector. Since the two are not equivalent, we provide some simple examples to compare the two criteria.
Theorems and algorithms for multiple view geometry with applications to electron tomography (2002)

The thesis considers both theory and algorithms for geometric computer vision. The framework of the work is built around the application of autonomous transmission electron microscope image registration.\n\nThe theoretical part of the thesis first develops a consistent robust estimator that is evaluated in estimating two view geometry with both affine and projective camera models. The uncertainty of the fundamental matrix is similarly estimated robustly, and the previous observation whether the covariance matrix of the fundamental matrix contains disparity information of the scene is explained and its utilization in matching is discussed. For point tracking purposes, a reliable wavelet-based matching technique and two EM algorithms for the maximum likelihood affine reconstruction under missing data are proposed. The thesis additionally discusses identification of degeneracy as well as affine bundle adjustment.\n\nThe application part of the thesis considers transmission electron microscope image registration, first with fiducial gold markers and thereafter without markers. Both methods utilize the techniques proposed in the theoretical part of the thesis and, in addition, a graph matching method is proposed for matching gold markers. Conversely, alignment without markers is disposed by tracking interest points of the intensity surface of the images. At the present level of development, the former method is more accurate but the latter is appropriate for situations where fiducial markers cannot be used.\n\nPerhaps the most significant result of the thesis is the proposed robust estimator because of consistence proof and its many application areas, which are not limited to the computer vision field. The other algorithms could be found useful in multiple view applications in computer vision that have to deal with uncertainty, matching, tracking, and reconstruction. From the viewpoint of image registration, the thesis further achieved its aims since two accurate image alignment methods are suggested for obtaining the most exact reconstructions in electron tomography.
IR 및 TPD 기법을 이용한 불균일계 촉매의 특성연구 (1987)

모더나이트를 전이금속으로 이오니교환하거나 수증기처리하여 산의 특성을 변화시키고 헤테로폴리산의 중심원자와 배위원자를 바꿈으로써 산특성을 변화시켰으며 ZSM-5를 여러가지 방법으로 제조하였다. 이들 촉매들에 암모니아 또는 피리딘을 흡착시킨 다음 TPD와 IR분석법에 의해 산의 종류 및 산점의 세기를 측정하였다. 촉매들의 산특성과 반응성간의 관계는 크실렌의 액상 이성화 반응, n-Butene의 이성화 반응, 톨루엔의 불균등화 반응 및 메탄올의 탄화수소에로의 전화반응과 관련지어 해석하였다. 승온탈착실험 결과 모더나이트와 ZSM-5는 두 개의 산점 즉 약산과 강산이 존재함을 확인하였으며 IR실험결과 이들에는 Lewis산과 Bro¨nsted산이 있음을 알았고 헤테로폴리산에는 Bro¨nsted산만이 존재함을 알았다. 크실렌의 이성화 반응 및 톨루엔의 불균등화 반응에서 강산이 생성물 선택성에 중요한 역할을 하며 탄소침적의 원인이 됨을 밝혔고 n-Butene의 이성화반응은 주로 약산에 의해 이루어짐을 밝혔다.
Surface coating reduces degradation rate of magnesium alloy developed for orthopaedic applications (2013)

Magnesium (Mg) or its alloys have shown great potential as promising biocorrosive or biodegradable implantation materials and/or internal fixators, owing to their good biocompatibility and osteoinductive potential. However, poor anticorrosion property or rapid biodegradation has limited their clinical applications where initial mechanical stabilisation is required. One of the practical approaches for decreasing its biodegradation is to introduce a coating on Mg or its alloys. The current study compared the two most widely used coating techniques, i.e., microarc oxidation (MAO) and electrophoresis deposition (EPD), for coating onto the Mg–Zr pin surface, both in vitro and in vivo, to determine which method can prevent Mg–Zr alloy degradation better. In vitro pH measurement and in vivo microcomputed tomographic evaluation were used for determining its degradation rate. Our in vitro and in vivo testing results indicated that EPD demonstrated better corrosion resistance than MAO, implying the potential of electrochemical technology for surface modification of Mg or its alloys developed for orthopaedic applications.
Polyethylenglycol-co-poly-D,L-lactide copolymer based microspheres: Preparation, characterization and delivery of a model protein (2008)

According to the results, PEG-D,L-PLA microspheres were more hydrophilic than PLA microparticles and with lower glass transition temperature. The surface of PEG-D,L-PLA microspheres was not as smooth as that of PLA microparticles, the mean diameter of PEG-D,L-PLA microparticles was bigger than that of PLA microspheres. Protein release from the microspheres was affected by the morphological structure of PEG-D,L-PLA microspheres and properties of PEG-D,L-PLA copolymer. This study suggests that PEG-D,L-PLA multiblock copolymer may be used as carrier in protein delivery systems for different purposes.
Extraurophyseal distribution of urotensin II immunoreactive neuronal perikarya and their processes (1986)

The use of the unlabeled antibody enzyme method on serially adjacent sections permitted the demonstration of urotensin II (UII) and urotensin I (UI) immunoreactivities colocalized in most of the cells of the caudal neurosecretory system of Catostomus commersoni. The study of the upper regions of the central nervous system from the spinal cord anterior to the fifth preterminal vertebral region up to and including the brain stem revealed the presence of UII immunoreactivity in cerebrospinal fluid-contacting neurons, located ventral to the central canal along the entire length of the spinal cord and medulla. Beaded nerve fibers were observed projecting to the ventrolateral surface of the spinal cord and also forming a seemingly ascending immunoreactive-UII longitudinal bundle directed toward the brain. The presence of this "extraurophyseal" system of immunoreactive-UII cells and fibers suggests that the UII peptide may be released in upper regions of the central nervous system in response to stimuli conveyed via the cerebral spinal fluid. Thus, separate functions may be postulated for the urophyseal and the cerebral spinal fluid-contacting urotensin II systems.