gebhart/patrepeval huggingface dataset:
Assessing the Feasibility of Augmenting Fall Detection Systems by Relying on UWB-Based Position Tracking and a Home Robot (2020)

Falls in the home environment are a primary cause of injury in older adults. According to the U.S. Centers for Disease Control and Prevention, every year, one in four adults 65 years of age and older reports experiencing a fall. A variety of different technologies have been proposed to detect fall events. However, the need to detect all fall instances (i.e., to avoid false negatives) has led to the development of systems marked by high sensitivity and hence a significant number of false alarms. The occurrence of false alarms causes frequent and unnecessary calls to emergency response centers, which are critical resources that should be utilized only when necessary. Besides, false alarms decrease the level of confidence of end-users in the fall detection system with a negative impact on their compliance with using the system (e.g., wearing the sensor enabling the detection of fall events). Herein, we present a novel approach aimed to augment traditional fall detection systems that rely on wearable sensors and fall detection algorithms. The proposed approach utilizes a UWB-based tracking system and a home robot. When the fall detection system generates an alarm, the alarm is relayed to a base station that utilizes a UWB-based tracking system to identify where the older adult and the robot are so as to enable navigating the environment using the robot and reaching the older adult to check if he/she experienced a fall. This approach prevents unnecessary calls to emergency response centers while enabling a tele-presence using the robot when appropriate. In this paper, we report the results of a novel fall detection algorithm, the characteristics of the alarm notification system, and the accuracy of the UWB-based tracking system that we implemented. The fall detection algorithm displayed a sensitivity of 99.0% and a specificity of 97.8%. The alarm notification system relayed all simulated alarm notification instances with a maximum delay of 106 ms. The UWB-based tracking system was found to be suitable to locate radio tags both in line-of-sight and in no-line-of-sight conditions. This result was obtained by using a machine learning-based algorithm that we developed to detect and compensate for the multipath effect in no-line-of-sight conditions. When using this algorithm, the error affecting the estimated position of the radio tags was smaller than 0.2 m, which is satisfactory for the application at hand.
Variations in the Bioactive Compounds Composition and Biological Activities of Loofah (Luffa cylindrica) Fruits in Relation to Maturation Stages (2017)

The present work aimed to determine the antioxidant and antiproliferative potential of Luffa cylindrica fruits collected at two different maturation stages and to identify and compare their functional components composition. The MeOH extracts of L. cylindrica fruits harvested at 60 - 65 days after seeding (S1) and 85 - 90 days after seeding (S2) were investigated for their antioxidant activity using various assays. Furthermore, the antiproliferative activity of the extracts against HeLa human cervical cancer cells was explored with xCELLigence real time cell analyzer, while the effect of the samples on the membrane integrity of the same cell line was assessed using LDH cytotoxicity leakage assay. Ultimately, the phytochemicals were analyzed using GC/MS and HPLC/TOF-MS. The S1 sample had higher contents and more diversity in the phenolic compounds composition than S2. Furthermore, the S1 extract showed the highest antioxidant and antiproliferative activity, while the S2 extract had higher cytotoxicity towards HeLa cells. The findings revealed that the time of harvest has a big impact on the phytochemicals content and activity and that harvesting L. cylindrica at an early stage before the beginning of the development of the cellulose fibrous system is recommended for a rich phytochemical composition and efficient antioxidant and antiproliferative activities.
Vertically coupled GaAs-AlGaAs and GaInAsP-InP microring resonators (2002)

Single transverse mode vertically coupled semiconductor microring resonators were made using a novel fabrication technique without regrowth. GaAs-AlGaAs and GaInAsP-InP devices are demonstrated.
[Séminaire] Spiking neural circuits and systems (2018)

SiNANO Multi-Scale Modelling Summer School, Tarragona, Catalonia, Spain
GM1‐gangliosidosis type I (2006)

A 10-month-old female presented with severe developmental delay. Physical examination revealed mildly coarse facial features with a wide nasal bridge, a mild deformity at the level of the lower thoracic spine, generalised hypotonia with decreased reflexes and hepatosplenomegaly. A blood film showed lymphocytes with multiple medium-sized vacuoles (top left), some of which contained a large azurophilic granule (bottom left) (Fig 1). The majority of eosinophilic granulocytes were pale and many contained large granules that were unevenly distributed within the cytoplasm (centre). Although abnormally vacuolated lymphocytes may be observed in infantile sialic acid storage disease, mannosidosis and GM1-gangliosidosis, the eosinophilic anomaly in addition is specific for GM1-gangliosidosis type I (Giltzemann et al, 1985). Two-dimensional glycosaminoglycan electrophoresis of the patient's urine was performed and revealed the presence of chondroitin sulphate (CS), heparan sulphate (HS) and keratan sulphate (KS) (right). The presence of KS is abnormal and is seen in patients with mucopolysaccharidosis type IV (Morquio syndrome) and GM1-gangliosidosis. White cell enzyme analysis revealed beta-galactosidase A deficiency and confirmed the diagnosis of GM1-gangliosidosis type I (infantile form).
Mutations in thyroid hormone receptor α1 cause premature neurogenesis and progenitor cell depletion in human cortical development (2019)

Mutations in the thyroid hormone receptor α 1 gene (THRA) have recently been identified as a cause of intellectual deficit in humans. Patients present with structural abnormalities including microcephaly, reduced cerebellar volume and decreased axonal density. Here, we show that directed differentiation of THRA mutant patient-derived iPSCs to forebrain neural progenitors is markedly reduced, but mutant progenitor cells can generate deep and upper cortical layer neurons and form functional neuronal networks. Quantitative lineage tracing shows that THRA mutation-containing progenitor cells exit the cell cycle prematurely, resulting in reduced clonal output. Using a novel micropatterned chip assay, we find that spatial self-organisation of mutation-containing progenitor cells is impaired, consistent with downregulated expression of cell-cell adhesion genes. These results reveal for the first time that thyroid hormone receptor α1 is required for normal neural progenitor cell proliferation and organisation in human cerebral cortical development. They also exemplify novel quantitative approaches for studying neurodevelopmental disorders using patient-derived cells in vitro.
Commensurate and modulated magnetic phases in orthorhombicAC60(A=K,Rb) (1995)

Competing magnetically ordered structures in polymerized orthorhombic A${\mathrm{C}}_{60}$ are studied. A mean-field theory for the equilibrium phases is developed using an Ising model and a classical Heisenberg model to describe the competition between interchain and intrachain magnetic order in the solid. In the Ising model, the limiting commensurate one-dimensional (1D) and three-dimensional phases are separated by a commensurate three-sublattice state and by two sectors containing higher-order commensurate modulated phases. For the Heisenberg model the quasi-one-dimensional phase is never the equilibrium state; instead the 3D commensurate phases exhibit a transition to a continuum of coplanar spiral magnetic phases.
Optimal Phase Response Functions for Fast Pulse-Coupled Synchronization in Wireless Sensor Networks (2012)

Synchronization is crucial to wireless sensor networks. Recently a pulse-coupled synchronization strategy that emulates biological pulse-coupled agents has been used to achieve this goal. We propose to optimize the phase response function such that synchronization rate is maximized. Since the synchronization rate is increased independently of transmission power, energy consumption is reduced, hence extending the life of battery-powered sensor networks. Comparison with existing phase response functions confirms the effectiveness of the method.
Challenges of γ9δ2TCR affinity maturation when using phage display (2021)

Abstract Background Over the past years we showed that the efficacy of αβT cells engineered to express a defined γδTCR (TEG) depends on the functional avidity of the γ9δ2TCR. We hypothesized that functional avidity mediated through γ9δ2TCR in the TEG format could be further enhanced by increasing affinity of the γ9δ2TCR. Methods We attempted to overcome limited affinity of natural occurring γ9δ2TCRs through affinity maturation by phage display using a library containing mutations in CDR1 and CDR2 of both TCR chains. Conclusion Affinity maturation of γ9δ2TCR by using phage display was not successful. The largest hurdle was the periplasmic expression of γ9δ2TCR constructs in E.coli which is a prerequisite for successful phage display. The underlying reason for this lack of expression was the instability of the single chain (sc)TCR format. Expression of scTCR formats in HEK293F cells yielded only 15-20% correctly folded scTCR.
Tribolium castaneum : Morphology of "Aureate" Revealed by the Scanning Electron Microscope (1967)

Counts of setae in "aureate" (au), spontaneous autosomal recessive mutation of good penetrance and viability, show that the au gene causes a three-fold increase in setation over the normal in the visible abdominal sternites but not in the membranous wings of the tenebrionid flour beetle Tribolium castaneum. Micrographs taken with the scanning electron microscope demonstrate that the au gene increases setation throughout the body.
Identity and pathogenicity of Botryosphaeriaceae and Diaporthaceae from Juglans regia in Chile (2022)

English walnut (Juglans regia) has become an important crop in Chile, representing 11.5% of the total area of fruit trees, surpassed only by grapevine. As the Chilean walnut industry rapidly expands, young orchards are at risk from the emergence of new fungal diseases. Botryosphaeriaceae and Diaporthaceae fungi have been recognized as main causes of wood diseases in walnut, with symptoms of dieback, canker, and blight. In winter 2017, samples were collected from different orchards in Valparaíso and Maule regions. Fungal isolates recovered were cultured, characterized morphologically, and identified using DNA sequence analyses. Three species (Neofusicoccum parvum, Diplodia mutila, Diplodia seriata) were characterized in Botryosphaeriaceae and two (Diaporthe cynaroidis, Diaporthe australafricana) in Diaporthaceae. Pathogenicity tests showed that N. parvum was the most aggressive species to walnut. This study confirmed the presence of pathogenic Botryosphaeriaceae and Diaporthaceae in J. regia that should be considered an increasing risk for the growing Chilean walnut industry.
Laryngeal pacing via an implantable stimulator for the rehabilitation of subjects suffering from bilateral vocal fold paralysis: A prospective first‐in‐human study (2015)

2b Laryngoscope, 126:1810-1816, 2016.
The Kinetics and Mechanism of α-Aminoisobutyronitrile Formation (1938)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Kinetics and Mechanism of α-Aminoisobutyronitrile FormationT. D. Stewart and Choh-hao LiCite this: J. Am. Chem. Soc. 1938, 60, 11, 2782–2787Publication Date (Print):November 1, 1938Publication History Published online1 May 2002Published inissue 1 November 1938https://pubs.acs.org/doi/10.1021/ja01278a068https://doi.org/10.1021/ja01278a068research-articleACS PublicationsRequest reuse permissionsArticle Views68Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Epilogue (2018)

This book shows how variations in endogenous factors or environmental factors might produce an infant that looks more like the infants that Klein described, and other factors might produce infants that look more like infants that Winnicott has described. It highlights that Freud’s theoretical base provides the widest support for a new theory, and that Kleinian and Bionian theory are compatible with that base. Both of these theorists have changed the landscape of therapeutic interactions. Hartmann’s concept of adaptation has been too easily overlooked, in part because of his attempt to rescue aspects of Freudian theory that were not salvagable. All of the factors indicate that any reductionist theory does not do justice to the multiple factors that influence human development and the therapeutic situation. Many self-psychoanalysts find Kleinian theory to be at odds with their theoretical views.
Adolescent Idiopathic Scoliosis: Update on Bracing, Surgical Techniques, and Patient Safety. (2017)

The primary goal in the management of adolescent idiopathic scoliosis is to prevent the progression of spinal deformity either with the use of a brace or with surgery. The goals of surgery, if indicated, are to correct the spinal deformity safely and to preserve overall spinal balance and as many motion segments as possible, which maximizes the long-term health of a patient's spine. Recently, tremendous advances have been made in the surgical techniques that are used to correct adolescent idiopathic scoliosis, and improved tools have allowed surgeons to perform spinal deformity surgery as safely and with as few complications as possible. Surgeons should be aware of recent evidence that demonstrates the efficacy of bracing in patients who have adolescent idiopathic scoliosis. In addition, surgeons should understand recent advances in spinal deformity surgery with regard to fusion level selection, implant placement, three-dimensional deformity correction, and techniques that are used to minimize perioperative complications.
Comparison of 4,4′-Dimethylbiphenyl from Biomass-Derived Furfural and Oil-Based Resource: Technoeconomic Analysis and Life-Cycle Assessment (2022)

Replacing oil-based toluene with biomass-derived furfural for 4,4′-dimethylbiphenyl (DMBP) production can pave the way for sustainable polyester manufacture. This work compared the economic and environmental performances of two conceptual designs of 4,4′-DMBP production. The first toluene-based route consists of toluene alkylation to (methylcyclohexyl)toluene (MCHT), MCHT dehydrogenation to DMBP, and isomerization of lower-valued 3,3′-DMBP. The renewable furfural-based route includes hydrogenation of furfural to 2-methylfuran (MF), oxidative coupling of MF to 5,5′-dimethylfuran (DMBF), and tandem Diels–Alder dehydration of 5,5′-DMBF to 4,4′-DMBP. The reaction conditions are optimized to achieve a more economically feasible process using furfural feedstock. At a scale of 83 kmol/h feedstock, the 4,4′-DMBP minimum selling price of the furfural-based route is $3044/t, while that of the toluene-based route is $2488/t. The feedstock and 3,4′-DMBP isomer prices are identified as critical parameters for the economic evaluation by sensitivity analysis. A “cradle-to-gate” life-cycle assessment confirms that furfural-based DMBP production emits significantly fewer greenhouse gas (5.00 kg CO2 equiv/kg DMBP) as compared to the toluene-based counterpart (8.28 kg CO2 equiv/kg DMBP).
Effects of Laundering on the Sensory and Mechanical Properties of 1 X 1 Rib Knitwear Fabrics (1996)

Acrylic, cotton, and wool 1 × 1 rib knitwear fabrics have been subjected to up to 50 laundering cycles using a variety of washing and drying conditions. The dimensional, mechanical, and tactile properties of new and washed fabrics are determined and evaluated using standard test procedures. In Part I, we establish the techniques for predicting the final, fully relaxed dimensions of knitted fabrics. We determine fully relaxed k-constant values and the influence of fiber type and washing and drying methods on these values. In Part II, we will discuss the changes in mechanical and tactile properties that occur in these fabrics with repeated washing.
Establishment and characterization of a fin cell line from Indian walking catfish, Clarias batrachus (L.) (2011)

A new cell line, Indian Catfish Fin, derived from the fin tissue of Indian walking catfish, Clarias batrachus, was established and characterized. The cell line grew well in Leibovitz's L-15 medium supplemented with 15% foetal bovine serum (FBS) and has been subcultured more than 110 times since its initiation in 2007. The cells were able to grow at a range of temperature from 28 to 37 °C with optimal growth at 28 °C. The cell line predominantly consists of fibroblast-like cells. The growth rate of fin cells increased as the FBS concentration increased from 2% to 20% at 28 °C with optimum growth at a concentration of 15% or 20% and poor growth at a concentration of 5%. The cells were found to be susceptible to fish nodavirus and IPNV-ab and infection was confirmed by cytopathic effect and reverse transcriptase-polymerase chain reaction. PCR amplification of mitochondrial 12S rRNA using primers specific to C. batrachus confirmed the catfish origin of the cell line. The cell line was characterized further by immunocytochemistry, transfection efficiency with pEGFP-N1 and cell cycle analysis by fluorescent-activated cell sorting.
Fragmentation of Neutral Oligosaccharides in Negative-ion MALDI Mass Spectrometry (2006)

負イオンMALDI質量分析法による中性オリゴ糖鎖の解析を行い、断片化の性質について調べるとともに、新規構造解析法を確立した。負イオンMALDI質量分析法ではイオン化に高エネルギー過程が含まれることを示唆する断片化の特徴が見られた。この高エネルギーな生成イオンの内部エネルギーを制御することで、その後の断片化反応を自由にコントロールすることができた。中性オリゴ糖の負イオン解析では結合異性や分岐構造に依存して特異的な断片化パターンを観測できたことから、正イオン解析では達成が困難であった詳細な構造解析にも有用であった。負イオンMALDI質量分析法による糖鎖解析は、糖鎖構造研究において幅広い応用が期待できる。
Use of the Analgesic, Anti-inflammatory and Neuroprotectant Supplement Palmitoylethanolamide in the Tarsal Tunnel Syndrome (2015)

Tarsal tunnel syndrome (TTS) is an entrapment neuropathy. Conservative treatment options include anti-inflammatory drugs not always lead to resolution, and although results of surgical decompression are good in selected patients, postoperative fibrosis can lead to recurrence of complaints. However, clinical studies in this field are pilot trials only, both for decompression techniques as well as for conservative interventions, and only few patients were evaluated in each trial. If one would select a treatment based on sufficient clinical studies, data in other compression syndromes should be considered.
Strain and Cation Stoichiometry in Epitaxial BaTiO3 Thin Films Grown on Silicon (2015)

International audience
ChemInform Abstract: SnCl2/Nano SiO2: A Green and Reusable Heterogeneous Catalyst for the Synthesis of Polyfunctionalized 4H‐Pyrans (2014)

Abstract via a one‐pot multicomponent cyclocondensation of aromatic aldehydes with CH acids, malononitrile and ethyl acetoacetate
A Kras Driven Murine Model Elucidates Oncogenic Role of FADD in lung cancer (2013)

Honors (Bachelor's)
26 IN VIVO EXOGENIC ORGAN GENERATION WITH ORGANOGENESIS-DISABLED CLONED PIGS AS A PLATFORM (2013)

The generation of organs from pluripotent stem cells (PSC) is one of the ultimate goals of regenerative medicine. We have demonstrated that functional organs can be generated in vivo from xenogenic PSC in the body of organogenesis-disabled mice using blastocyst complementation. To apply this principle in generating human organs, a technical platform using large non-rodent mammals is essential. The aim of the present study was to establish a blastocyst complementation system using cloned pig embryos. We generated transgenic-cloned pigs with an apancreatic phenotype via the overexpression of Hes1 (hairy and enhancer of split-1) under the Pdx1 promoter (pancreatic and duodenal homeobox-1). Cloned embryos of apancreatic pigs (host embryos, male) were complemented (i.e. chimerized) by blastomeres of cloned embryos (donor cells, female) with normal developmental competence. Chimeric embryos were cultured for 1 or 2 days before being transferred into the uteri of oestrus-synchronized gilts. The complementation of 292 Pdx1-Hes1 cloned embryos gave rise to 260 (89.0%) blastocysts. The transfer of these blastocysts resulted in 5 male chimeric pigs. Chimerism was confirmed by the detection of host embryo-derived Pdx1-Hes1 and marker transgenes of the donor cells, such as humanized Kusabira-Orange (huKO) or Pdx1-Venus. Chimeric pigs possessed normally formed pancreata entirely derived from the exogenous donor cells. We thus established a blastocyst complementation system in the pig using cloned embryos that would otherwise give rise to apancreatic animals. Chimeric pigs obtained developed normally, maintaining normal serum glucose concentrations up to maturity, and became fertile boars. Mating the chimeric boars with 7 wild-type sows gave rise to 72 fetuses/piglets of which 37 (51.4%) exhibited the apancreatic phenotype. These results indicate that a missing organ can be generated from exogenous cells when functionally normal pluripotent cells chimerize with a cloned dysorganogenetic embryo. Blastocyst complementation using cloned porcine embryos may permit the use of a large animal for the generation of functional organs from xenogenic PSC, including human iPSC. The chimeric boar produced by blastocyst complementation sired fetuses/offspring with the apancreatic phenotype in a Mendelian fashion. Porcine fetuses with an organogenesis-disabled phenotype may provide a useful platform for organ regeneration research. Table 1. Production of chimeric pigs by complementation and of Pdx1-Hes1 cloned embryos
Superpipelined control and data path synthesis (1992)

The authors describe a superpipelined control and data path synthesis system. The system can handle pipelined modules in the data path, perform functional pipelining in the data path, and schedule the data path using a pipelined controller. Three control styles-serial, parallel, and pipelined-were implemented. The system automatically picks one depending on the data path, the clock frequency, and the functional unit and control path delays. The results showed that using a modifiable clock cycle time and a parameterized control style can significantly improve the throughput of high-performance systems. >
Plasmonic Nanostructures with Well-Controlled Geometry Lead to Designed Properties (2015)

Near field coupling between metallic particles opens a route for controlling light-matter interaction at nanometer length scale. Novel and desirable properties of plasmonic nanostructures can be realized by precisely control the geometry of nanoparticles.