gebhart/patrepeval huggingface dataset:
Reduction of Carbonyl Groups by a Model for a Coenzyme (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReduction of Carbonyl Groups by a Model for a CoenzymeDonald C. Dittmer and Roger A. FoutyCite this: J. Am. Chem. Soc. 1964, 86, 1, 91–95Publication Date (Print):January 1, 1964Publication History Published online1 May 2002Published inissue 1 January 1964https://pubs.acs.org/doi/10.1021/ja01055a021https://doi.org/10.1021/ja01055a021research-articleACS PublicationsRequest reuse permissionsArticle Views182Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Galantamine for vascular cognitive impairment (2004)

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the efficacy of galantamine in the treatment of people with vascular cognitive impairment, vascular dementia, and mixed dementia.
Mars Array Technology Experiment (MATE) [space power solar cell performance] (2002)

Airborne and settled dust on the surface of Mars alters the sunlight and fluctuates from day to day, it affects both the intensity and spectral content. Future missions to Mars are considering solar power and therefore solar cell technologies must be evaluated to find the optimum. The MATE flight experiment was designed for this purpose as part of the Mars In-Situ Propellant Production Precursor (MIP) package destined to fly on the now defunct '01 Lander. MATE will measure the performance of several solar cell technologies and characterize the Martian environment in terms of solar power. This will be done by measuring full IV curves on solar cells, direct and global insolation, temperature, and spectral content. MATE is qualified for a site location near the equator for 100 to 300 days. The intent of this paper is to provide a brief overview of this experiment.
Long-distance quantum key distribution in optical fibre (2006)

Use of low-noise detectors can both increase the secret bit rate of long-distance quantum key distribution (QKD) and dramatically extend the length of a fibre optic link over which secure key can be distributed. Previous work has demonstrated use of ultra-low-noise transition-edge sensors (TESs) in a QKD system with transmission over 50 km. In this work, we demonstrate the potential of the TESs by successfully generating error-corrected, privacy-amplified key over 148.7 km of dark optical fibre at a mean photon number mu = 0.1, or 184.6 km of dark optical fibre at a mean photon number of 0.5. We have also exchanged secret key over 67.5 km that is secure against powerful photon-number-splitting attacks.
Resource sharing for replicated synchronous groupware (2001)

We describe problems associated with accessing data resources external to the application, which we term externalities, in replicated synchronous collaborative applications. Accessing externalities such as files, databases, network connections, environment variables, and the system clock is not as straightforward in replicated collaborative software as in single-user applications or centralized collaborative systems. We describe ad hoc solutions that add to development cost and complexity because the developer must program different behavior for different replicas. We introduce a novel general approach to accessing externalities uniformly in a replicated collaborative system. The approach uses a semireplicated architecture where the actual externality resides at a single location and is accessed via replicated proxies. This approach allows developers of replicated synchronous groupware to (1) use similar externality access mechanisms as in traditional single-user applications, and (2) program all replicas to execute the same behavior. We describe a general design for proxied access to read-only, write-only, and read-write externalities and discuss the tradeoffs of this semireplicated approach over full, literal replication and the class of applications to which this approach can be successfully applied. We also describe details of a prototype implementation of this approach within a replicated collaboration-transparency system, called Flexible JAMM (Java Applets Made Multiuser).
Place des agricultures européennes dans le monde à l’horizon 2050 : Entre enjeux climatiques et défis de la sécurité alimentaire mondiale (2021)

Le present rapport rassemble les revues de la litterature scientifique internationale realisees par le collectif d’experts scientifiques constitue dans le cadre de l’etude « Place des agricultures europeennes dans le monde a l’horizon 2050 : entre enjeux climatiques et defis de la securite alimentaire » (ci-apres designee par l’acronyme AE2050).
Pour rappel, l’etude AE2050 consiste a examiner, au moyen d’un modele de bilans (GlobAgri-AE2050 ), l’evolution des surfaces, des niveaux de productions, et des echanges mondiaux de produits agricoles a l’horizon 2050 dans chacune des regions du monde , en fonction (i) de celle de la demande en produits agricoles (notamment liee a la croissance demographique et aux evolutions des regimes alimentaires) et (ii) des caracteristiques clefs des systemes agricoles que sont les rendements (vegetaux et animaux), les intensites culturales et les disponibilites en terres. On cherche, dans cette etude, a integrer autant que possible les effets du changement climatique dans la projection des variables clefs decrivant les systemes agricoles.
Effect of optic edge design and haptic angulation on postoperative intraocular lens position change (2004)

Optic edge design influenced postoperative axial optic movement and thus had an impact on the development of postoperative refraction (refractive shift, deviation from target refraction). The influence of optic-haptic angulation proved to be significantly greater and more variable than edge design.
Wood quality of Pinus taeda and Pinus sylvestris for kraft pulp production (2015)

The objective of this work was to evaluate the technological characteristics of the woods of Pinus taeda and Pinus sylvesttis to Kraft pulp production. Industrial chips of both species were used: Pinus taeda from Brazil and Pinus sylvestris from Finland. On wood technological characteristics analysis, basic density, chemical composition and tracheid's morphology were determined. On pulping, seven levels of active alkali were applied between 14 and 26% (NaOH based), with 90 minutes of heating time and 120 minutes at maximum temperature of 170 degrees C. It was possible to observe that both analyzed woods present similar basic density and lignin portions (0,435 e 0,436 g.cm(-3), 26,71 and 25,61% for P taeda and P sylvestris, respectively), while the wood of P. taeda presents lower extractives portion (2,83%), higher holocellulose content (70,46%) and tracheids with higher length (3,50mm), when compared to P sylvestris wood. On pulping, the wood of P taeda had higher yields, higher delignification level and lower wood specific consumption. From this we conclude that the P taeda wood has better characteristics for pulp and paper production when compared to P sylvestris.
Micro-structured heat exchanger for cryogenic mixed refrigerant cycles (2017)

Mixed refrigerant cycles (MRCs) offer a cost- and energy-efficient cooling method for the temperature range between 80 and 200 K. The performance of MRCs is strongly influenced by entropy production in the main heat exchanger. High efficiencies thus require small temperature gradients among the fluid streams, as well as limited pressure drop and axial conduction. As temperature gradients scale with heat flux, large heat transfer areas are necessary. This is best achieved with micro-structured heat exchangers, where high volumetric heat transfer areas can be realized. The reliable design of MRC heat exchangers is challenging, since two-phase heat transfer and pressure drop in both fluid streams have to be considered simultaneously. Furthermore, only few data on the convective boiling and condensation kinetics of zeotropic mixtures is available in literature. This paper presents a micro-structured heat exchanger designed with a newly developed numerical model, followed by experimental results on the single-phase pressure drop and their implications on the hydraulic diameter.
Montmorillonite−Supramolecular Hydrogel Hybrid for Fluorocolorimetric Sensing of Polyamines (2011)

Fluorescent sensor materials for rapidly and conveniently detecting polyamines in biological fluids are highly desirable for cancer diagnosis. We herein describe the hybridization of a supramolecular hydrogel with a layered inorganic host adsorbing a fluorescent dye which produces a fluorocolorimetric sensor for spermine and spermidine, important biomarkers for cancers, in artificial urine.
Explicit Online Least Costly Energy Management for Hybrid Electric Vehicles (2020)

In this paper, a numerical solution to the online least costly energy management problem for hybrid electric vehicles is illustrated. The key idea is that the optimal control problem corresponding to the least costly energy management task is here solved for different steady-state working points, so that explicit quasi-optimal power split maps suitable for realtime vehicle operation can be derived. The effectiveness of the proposed approach is shown within a simulation environment for the control of an extended range electric bus.
P91 Multi-professional in-situ ward round simulation promotes shared learning whilst breaking down barriers to silo working (2017)

Background The ward round is central to hospital activity. It is a complex multi-professional multifactorial process with the aim of providing high quality patient centred care in a reliable, reproducible and timely manner. This was recognised in the joint publication Ward Rounds in Medicine from the Royal College of Physicians, Royal College of Nursing where the requirement for structured multidisciplinary rounds and robust training strategies were highlighted. 1 Multi-professional training is linked to patient safety, care and experience. Our aim is to describe and evaluate a multi-professional in-situ ward round simulation programme. Methodology A low-fidelity simulated ward round environment was set up in a designated area on Theatre recovery. The in-situ ward round simulation sessions ran weekly over a period of 5 weeks. The multi-professional group was made up of therapists, junior doctors, senior decision makers, nursing staff, pharmacists, allied health care professionals and patient simulated actors. Two simulated scenarios were completed with an equal share of time devoted to group debrief following each simulation exercise. Emphasis on communication, teamwork and human factors with the impact on patient care, experience and flow was developed. Results A Likert-Scale was used to collate feedback, with overwhelmingly positive results. 94% of respondents agreed or strongly agreed that the in-situ simulated ward rounds were beneficial to their continued professional development (CPD); 88% of respondents felt more confident in understanding the roles of their team members and 75% felt more confident in participating in ward rounds. The debrief exercise was highly regarded as excellent, with 100% of respondents rating it as a useful learning opportunity. The debrief provided a forum for all members of the multi-professional team to input and create a shared learning environment, empowering the participants with an equal voice. Conclusion Multi-professional in-situ low fidelity simulation ward rounds promote shared learning and improved communication whilst removing barriers to silo working. This may result in improved patient care and experience with better patient flow. References . Royal College of Physicians, Royal College of Nursing. Ward rounds in medicine: principles for best practice 2012. London: RCP. . Creamer GL, Dahl A, Pareumal D, et al . Anatomy of the ward round: the time spent in different activities. ANZ Journal of Surgery 2010;80:930–2. . Cohn A. Restore the prominence of the medical ward round. BMJ 2013;347:f6451. . Powell N, Bruce CG, Redfern O. Teaching a good ward round. Clinical Medicine 2015;15:135–8.
Differential Expression of Porcine Major Histocompatibility DNA Sequences Introduced into Mouse L Cells (1983)

The expression of a porcine genomic DNA segment containing a major histocompatibility gene and its chromatin structure in mouse L cells have been investigated. The transformed cells, which contain about two copies of the 17.8-kilobase pig DNA insert per haploid genome, stably and uniformly express major histocompatibility antigen on their surfaces. This expression is the result of differential transcription of the 3-kilobase major histocompatibility gene; the other 14 kilobases of pig sequences flanking the coding sequence are not transcribed. Although the entire pig DNA segment is packaged into nucleosomes, only the transcriptionally active DNA sequences are packaged in a DNase I-sensitive conformation. These results suggest that the expression of this foreign DNA is actively regulated in L cells.
Cardiac magnetic resonance in heart failure with preserved ejection fraction: myocyte, interstitium, microvascular, and metabolic abnormalities (2020)

Heart failure (HF) with preserved ejection fraction (HFpEF) is a chronic cardiac condition whose prevalence continues to rise, with high social and economic burden, but with no specific approved treatment. Patients diagnosed with HFpEF have a high prevalence of comorbidities and exhibit a high misdiagnosis rate. True HFpEF is likely to have multiple pathophysiological causes - with these causes being clinically ill-defined due to limitations of current measurement techniques. Myocyte, interstitium, microvascular, and metabolic abnormalities have been regarded as key components of the pathophysiology and potential therapeutic targets. Cardiac magnetic resonance (CMR) has the capability to look deeper with a number of tissue characterization techniques which are closer to the underlying specific abnormalities and which could be linked to personalized medicine for HFpEF. This review aims to discuss the potential role of CMR to better define HFpEF phenotypes and to infer measurable therapeutic targets.
Automated problem list generation and physicians perspective from a pilot study (2017)

Cognitive computing systems like this Watson system hold the potential for accurate, problem-list-centered summarization of patient records, potentially leading to increased efficiency, better clinical decision support, and improved quality of patient care.
Regulation of CD19 surface expression in human B cells by CD81 (P3323) (2013)

Abstract A girl was diagnosed with primary antibody deficiency. Her B cells lacked surface CD19, although both alleles were normal. The cause was a homozygous exon splice site mutation in CD81(1). This human deficiency differs from CD81 knockout mice, in which surface CD19 is lower but not completely absent. The patient’s EBV-transformed B cells were used to determine how CD81 controls the trafficking of CD19. We show that the CD81 mutant (CD81mut) protein is expressed intracellularly in the patient’s B cells. Using a proximity ligation assay we also demonstrate that the truncated CD81mut protein interacts intracellularly with CD19. This interaction with the CD81mut protein abrogates carbohydrate maturation and trafficking of CD19 to the cell surface. However, expression of CD81mut did not exert a dominant negative effect on CD19 surface expression in B cells that express or lack CD81. Finally, using a reconstitution system we identify specific CD81 domains that restore carbohydrate maturation and cell surface expression of CD19 in the patient’s B cells. This specific case of antibody deficiency was manifested because of lack of surface expression of CD19, an important B cell signaling molecule. However, the maturation of CD19 and its trafficking to the cell surface require the presence of specific domains of the tetraspanin CD81 molecule. 1.van Zelm et al (2010) CD81 human gene defect disrupts CD19 complex formation and leads to antibody deficiency. J Clin Invest. 120: 1265.
Can dendritic cells improve whole cancer cell vaccines based on immunogenically killed cancer cells? (2015)

Immunogenic cell death (ICD) offers interesting opportunities in cancer cell (CC) vaccine manufacture, as it increases the immunogenicity of the dead CC. Furthermore, fusion of CCs with dendritic cells (DCs) is considered a superior method for generating whole CC vaccines. Therefore, in this work, we determined in naive mice whether immunogenically killed CCs per se (CC vaccine) elicit an antitumoral immune response different from the response observed when immunogenically killed CCs are associated with DCs through fusion (fusion vaccine) or through co-incubation (co-incubation vaccine). After tumor inoculation, the type of immune response in the prophylactically vaccinated mice differed between the groups. In more detail, fusion vaccines elicited a humoral anticancer response, whereas the co-incubation and CC vaccine mainly induced a cellular response. Despite these differences, all three approaches offered a prophylactic protection against tumor development in the murine mammary carcinoma model. In summary, it can be concluded that whole CC vaccines based on immunogenically killed CCs may not necessarily require association with DCs to elicit a protective anticancer immune response. If this finding can be endorsed in other cancer models, the manufacture of CC vaccines would greatly benefit from this new insight, as production of DC-based vaccines is laborious, time-consuming and expensive.
Interventional radiologic procedures in liver transplantation (2001)

Postoperative biliary and vascular complications contribute significantly to morbidity and mortality in liver transplantation. Interventional radiologists are an integral part of the multidisciplinary team necessary for optimizing the management of these complications. During a 15-year period, 39 cadaveric and 25 living related liver transplantations were performed at the Chang Gung Memorial hospital, Taiwan. Of 64 liver transplant recipients, 9 (3 adult and 6 pediatric) underwent 13 interventional radiological procedures for the treatment of biliary sludge-casts (n = 2), bile duct occlusion or stenosis (n = 2), hepatic veins thrombosis (n = 1), hepatic veins stenosis (n = 1), portal vein stenosis with splenorenal shunting (n = 1), biloma (n = 1), and infected fluid collection or ascites (n = 4). Antegrade or retrograde interventional approach was used to successfully treat all biliary complications, and all percutaneous drainage procedures were effective in the control of intra-abdominal fluid collections. Portal vein stenosis was treated by balloon dilatation, and the associated splenorenal shunt was closed by metallic coil embolization via transhepatic catheterization of the portal vein. Hepatic vein stenosis was effectively treated by balloon dilatation and expandable metallic stent deployment via transfemoral and jugular venous approaches, respectively. Hepatic vein thrombosis was only partially lysed by transvenous streptokinase administration, and surgical thrombectomy was needed to achieve complete recanalization. The total success rate of the interventional procedures was 92 % with no procedure-related complications. The overall survival rate in this series is 89 %, and all patients who underwent living related liver transplantation maintain to date a 100 % survival rate. We can conclude that interventional radiological procedures are very useful for managing biliary and vascular complications after liver transplantation. These techniques provide a cure in most situations, thus obviating the need for further surgical intervention or re-transplantation.
Stereoselectivity (2023)

This Glossary contains definitions, explanatory notes, and sources for terms used in physical organic chemistry. Its aim is to provide guidance on the terminology of physical organic chemistry, with a view to achieving a consensus on the meaning and applicability of useful terms and the abandonment of unsatisfactory ones. Owing to the substantial progress in the field, this 2021 revision of the Glossary is much expanded relative to the previous edition, and it includes terms from cognate fields.
A clinical study of Cyberknife treatment for oral squamous cell carcinoma (2020)

Cyberknife (CK) is one of the treatment options for oral squamous cell carcinoma. However, there are few reports regarding treatment with CK in Japan, and standard criteria defining indications have not been established. We often perform radiation therapy with CK in patients who cannot undergo standard therapy because of extremely advanced disease, high-risk general conditions, refusal of surgery, or other reasons. We retrospectively assessed 32 patients treated from 2006 to 2017 and evaluated the clinical significance. Within 4 months after CK treatment, the response rate was 72%. The overall survival rates at 2 years and 5 years were 42% and 15%, respectively, and the median survival was 23 months. Clinical factors for CK treatment outcomes were explored. The results showed that primary tumor size (T classification), stage, irradiation timing, and planning target volume (PTV) were statistically significant factors. Tumors with a small diameter at the time of primary onset could be controlled similar to surgery in terms of the 3-year survival rate. This study suggested that CK treatment might be an effective treatment for tumor suppression in patients in whom no other treatment was indicated.
即時定量 PCR 檢測基因改造玉米及大豆之量測不確定度評估 (2014)

現今，由於全球基因改造生物(Genetically Modified Organisms,GMOs)持續的發展，人們逐漸重視其對生態、國際貿易與食品安全的影響。為確保民眾在基改作物、傳統栽培作物和有機作物間，有知道且自由選擇的權利，各國便制定基改生物相關之法規閾值，為了因應相關之管理規定，基改作物定量分析相當重要。對於一個給定樣本重複量測其基改作物含量，無論在同一實驗室內或不同實驗室間，可預期的是無法測得相同的值。量測不確定度為描述量測結果變動範圍的一個參數，若定量結果附上其不確定度便更能正確解釋其結果。目前有數種估計量測不確定度的方法，一種是先估計試驗中每個步驟各別不確定度，再組合成最終量測不確定度的 bottom-up 策略，另一個為top-down 策略，是由試驗所得數據直接估計其量測不確定度。

本研究以 top-down 及 bottom-up 評估策略，估計定量分析基因改造大豆 DP-305423 與玉米 NK603 品項之認證參考物質的量測不確定度。以 top-down 策略所得量測不確定度結果介於 6.26%與 24.71%之間；bottom-up 策略所得量測不確定度結果為 24.75%與 31.99%。並且發現主要不確定度來源為樣本製備 約占總變異的 72.12 至 94.73%。，在實行上各策略有其優、缺點，以 top-down 策略來說，可以試驗的數據估計量測不確定度，而不必再額外設計試驗獲得不確定度，bottom-up 策略則是能成功考慮量測過程中各個影響因子。最後本研究以符合性評估(conformity assessment)解釋量測不確定度如何影響判斷定量結果是否符合規定，提供給決策者判定樣本是否符合規範的依據。