gebhart/patrepeval huggingface dataset:
Stereoselective synthesis of Arabidopsis CLAVATA3 (CLV3) glycopeptide, unique protein post-translational modifications of secreted peptide hormone in plant (2013)

The unique hydroxylproline (Hyp)-linked O-glycan modification is a common process in hydroxyproline-rich glycoproteins (HRGPs). The modification occurs through post-translational hydroxylation at 4-position of proline residues some of which are followed by O-glycosylation at the resulting Hyp which is also found in some secreted peptide hormones such as CLAVATA3 (CLV3) of Arabidopsis thaliana plants. An active mature CLV3 is a tridecapeptide linked to β-L-Araf-(1→2)-β-L-Araf-(1→2)-β-L-Araf at a Hyp residue in the center of the peptide sequence such as Arg-Thr-Val-Hyp-Ser-Gly-Hyp(L-Arafn)-Asp-Pro-Leu-His-His-His (n = 3). We report here the synthesis of the secreted and modified CLV3 glycopeptide with all glycoforms (Araf0-3CLV3) of A. thaliana plants. A highly stereoselective β-arabinofuranosylation of Hyp derivatives as the key step of the synthesis of CLV3 glycopeptide was achieved by NAP ether-mediated IAD, which was effectively applied to the synthesis of oligoarabinosylated hydroxylproline [Hyp(L-Araf1-3)] derivatives. Fmoc-solid phase peptide synthesis was carried out using COMU as the coupling reagent for the introduction of [Hyp(L-Araf0-3)] derivatives as well as further elongation to the CLV3 glycopeptides.
The Radiolabeling of Lymphocytes and Tumor Cells with 111Indium (1978)

Summary111Indium when complexed with oxine is an efficient label of lymphocytes and tumor cells. 111Indium-oxine complex (111InOx) is not reutilizable, making it useful for short-term lymphocyte recirculation studies. The spontaneous release of 111InOx from tumor cells is very low, making it a useful isotope in cytotoxicity studies. 111InoX emits two γ photons detectable by nuclear scanning, making this label of potential use in the study of lymphocyte migration in man.
Coverage‐based treatment planning to accommodate delineation uncertainties in prostate cancer treatment (2015)

When the delineation uncertainties need to be considered for prostate patients, CP techniques can produce more desirable plans than FM plans for most patients. The relative advantages between CPCOP and CPOM techniques are patient specific.
ChemInform Abstract: KINETIK DER RK. VON HETEROCYCLEN 7. MITT. SUBSTITUTION DER TRIMETHYLAMMONIOGRUPPE IN SUBSTITUIERTEN PURINEN DURCH DAS HYDROXID‐ION (1971)

Abstract Die Purine (Ib) und (IIIb) werden aus den entsprechenden Verbindungen (Ia) und (IIIa) mit Trimethylamin in Benzol, DMF oder Aceton unterhalb 53°C dargestellt.
The intelsat tdma burst mode link analyser (1985)

Abstract In any wide bandwidth transmission system, the equalization of amplitude and group delay plays an important part in obtaining acceptable transmission quality. In the forthcoming INTELSAT TDMA/DSI system the need to measure the amplitude and group delay response in a time‐shared 80 MHz transponder has led to the design and construction of a new measuring instrument: the burst mode link analyser (BMLA). In this paper, the design principles and method of operation of the BMLA are discussed, together with an overview of its internal architecture.
Optimal scheduling for streaming of scalable media (2002)

Scalable, or layered, media representation appears to be more suitable for transmission over the current heterogeneous networks. In this paper we study the problem of scalable layered streaming media delivery over a lossy channel. The goal is to find an optimal transmission policy to achieve the best playback quality at the client end. The problem involves some trade-offs such as time-constrained delivery and data dependencies. For example, a layer should be dropped before transmission if it already has a delay such that it cannot be played before its scheduled time. Moreover, less important layers with near-playback-time may also be dropped or delayed for delivery in order to save bandwidth for other layers with a high priority. We propose a framework for scalable streaming media delivery, that involves a novel scheduling algorithm called Expected runtime Distortion Based Scheduling (EDBS) which decides the order in which packets should be transmitted in order to improve client playback quality in the presence of channel losses. A fast greedy search algorithm is presented that achieves almost the same performance as an exhaustive search technique (98% of the time it results in the same schedule) with very low complexity and is applicable for real-time application.
Magnetic Tunnel Junctions With [Co/Pd]-Based Reference Layer and CoFeB Sensing Layer for Magnetic Sensor (2016)

We investigated the tunneling magnetoresistance (TMR) properties for the magnetic sensor application in MgO-based magnetic tunnel junctions (MTJs) using a perpendicularly magnetized [Co/Pd]-based reference layer and an in-plane magnetized CoFeB sensing layer with various thicknesses (tCoFeB). Linear TMR curves to an out-of-plane magnetic field were successfully obtained with a dynamic range of more than 600 Oe, corresponding to the coercivity of the [Co/Pd]-based reference layer. The MTJs showed the highest sensitivity of 0.026%/Oe for tCoFeB = 1.8 nm and the smallest nonlinearity of 0.11% full scale for t <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">CoFeB</sub> = 3 nm. We clarified that the sensitivity and the nonlinearity in the MTJs are significantly associated with t <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">CoFeB</sub> , which is attributed to the change in the anisotropy field of the CoFeB sensing layer.
Mouse mammary gland is refractory to the effects of ethanol after natural lactation. (2013)

Ethanol is a dietary factor that dose-dependently increases breast cancer risk in women. We previously have shown that ethanol increases mammary epithelial density through increased branching after dietary exposure during puberty in CD2/F1 mice. To extend these studies to parous mice in a breast cancer model, we used a transgenic mouse model of human parity-associated breast cancer, the FVB-MMTV-Her2/Neu mouse, which overexpresses wildtype EGFR2, resulting in constitutive activation of growth signaling in the mammary epithelium. Here we describe the short-term effects of ethanol feeding on progression through involution. Mice were fed diets supplemented with 0%, 0.5%, 1%, or 2% ethanol for 4, 9, or 14 d starting on day 21 of lactation (that is, at the start of natural postlactational involution). Unlike peripubertal mice exposed to ethanol, postlactational dams showed no changes in body weight; liver, spleen, and kidney weights; and pathology. Ethanol exposure had no effect on mammary gland lobular density and adipocyte size throughout involution. Likewise, the infiltration of inflammatory cells and serum oxidized lipid species were unchanged by diet, suggesting that ethanol feeding had no effect on local inflammation (leukocyte infiltration) or systemic inflammation (oxidized lipids). In conclusion, ethanol exposure of parous dams had no effect on mammary gland structure or the regression of the lactating mammary gland to a resting state. The period of involution that follows natural lactation appears to be refractory to developmental effects of ethanol on mammary epithelium.
Management of raised blood pressure in New Zealand: a discussion document. (1993)

A report to the National Advisory Committee on Core Health and Disability Support Services, New Zealand, on the management of raised blood pressure recommends that decisions to treat raised blood pressure should be based primarily on the estimated absolute risk of cardiovascular disease rather than on blood pressure alone. In general, patients with a blood pressure of 150-170 mm Hg systolic or 90-100 mm Hg diastolic, or both, should be given treatment to lower blood pressure if the risk of a major cardiovascular disease event in 10 years is more than about 20%. The results of clinical trials indicate that, at this level of absolute risk, 150 people would require treatment to reduce the annual number of cardiovascular events by about one. Implementation of these recommendations may result in a smaller proportion of people aged under 60, particularly women, receiving treatment but an increased proportion of older people treated. In the absence of specific contraindications, low dose diuretics and low dose beta blockers should be considered for first line treatment, since for only these drug groups is there direct evidence of reduced risk of stroke and coronary disease in people with raised blood pressure.
Clinical Implications of Identifying Pathogenic Variants in Individuals With Thoracic Aortic Dissection (2019)

Clinical genetic testing of known hereditary thoracic aortic dissection genes should be considered in patients with a thoracic aortic dissection, followed by cascade screening of family members, especially in patients with age-of-onset <50 years, family history of thoracic aortic disease, and no history of hypertension.
Mice With Monoallelic GNAO1 Loss Exhibit Reduced Inhibitory Synaptic Input To Cerebellar Purkinje Cells (2021)

Abstract GNAO1 encodes Gα o , a heterotrimeric G protein alpha subunit in the G i/o family. In this report, we used a Gnao1 mouse model “G203R” previously described as a “gain-of-function” Gnao1 mutant with movement abnormalities and enhanced seizure susceptibility. Here, we report an unexpected second mutation resulting in a loss-of-function Gα o protein and describe alterations in central synaptic transmission. Whole cell patch clamp recordings from Purkinje cells (PCs) in acute cerebellar slices from Gnao1 mutant mice showed significantly lower frequencies of spontaneous and miniature inhibitory postsynaptic currents (sIPSCs and mIPSCs) compared to WT mice. There was no significant change in sEPSCs or mEPSCs. Whereas mIPSC frequency was reduced, mIPSC amplitudes were not affected, suggesting a presynaptic mechanism of action. A modest decrease in the number of molecular layer interneurons was insufficient to explain the magnitude of IPSC suppression. Paradoxically, G i/o inhibitors (pertussis toxin), enhanced the mutant-suppressed mIPSC frequency and eliminated the difference between WT and Gnao1 mice. While GABA B receptor regulates mIPSCs, neither agonists nor antagonists of this receptor altered function in the mutant mouse PCs. This study is the first electrophysiological investigation of the role of G i/o protein in cerebellar synaptic transmission using an animal model with a loss-of-function G i/o protein. Significance Statement This is the first report on the electrophysiological mechanisms of a movement disorder animal model with monoallelic Gnao1 loss. This study illustrates the role of Gα o protein in regulating GABA release in mouse cerebellum. This study could also facilitate the discovery of new drugs or drug repurposing for GNAO1 -associated disorders. Moreover, since GNAO1 shares pathways with other genes related to movement disorders, developing drugs for the treatment of GNAO1 -associated movement disorders could further the pharmacological intervention for other monogenic movement disorders.
Clinical significance and changes of the level of tumor necrosis factor - alpha, angiotensin II, hemoglobin, interleukin - 10, interleukin -4 in eldly patients with chronic heart failure (2011)

Objective To study the clinical significance and changes of the level of tumor necrosis factor - alpha ( TNF - α),angiotensin Ⅱ ( A Ⅱ ),hemoglobin ( Hb ),Interleukin - 10 ( IL - 10 ),interleukin - 4 ( IL - 4) in eldly patients with chronic heart failure.Methods There were thirty patients with chronic heart failure in observation group and thirty healthy people in control group.Level of TNF - α,A Ⅱ,Hh,IL- 10,IL- 4 were detected separately and compared between the two groups.Results In observation froup,the level of Hb decreased gradually,IL - 10 decreased with chronic heart failure aggravation,TNF-α,AⅡ were progressively increased( P ＜ 0.05 ),there was no significant difference between the two groups in the level of IL - 4 (P ＞ 0.05 ).In the control group,the level of Hb,IL - 10 were negative correlated with the level of TNF - α,A Ⅱ ( P ＜ 0.05 ).Conclusions The level of TNF - α,A Ⅱ,Hb,IL- 10 are closely related with cardiac functional grading and inflammatory factor in eldly patients with chronic heart failure.Well controlled hemoglobin level and standard treatment may obviously reduce significant change,improve patient' s heart functional and prognosis.

Key words: 
Chronic heart failure; Tumour necrosis factor - alpha; Angiotensin Ⅱ; Hemoglobin; Interleukin - 10; Interleukin - 4
Cathedrals and castles (2009)

The American Henry James' descriptions of the countryside, monuments, universities, cathedrals, castles, customs and manners of the English are filled with elegant charm and good humour. Here he delights in the hidden corners of ancient Chester streets, marvels at the drunken jollity of Epsom Derby day and savours the calm shadows of Glastonbury abbey, in a hymn to stained-glass windows, crumbling cottages, Norman towers, weather-beaten gables and the English genius. Generations of inhabitants have helped shape the English countryside - but it has profoundly shaped us too. It has provoked a huge variety of responses from artists, writers, musicians and people who live and work on the land - as well as those who are travelling through it.English Journeys celebrates this long tradition with a series of twenty books on all aspects of the countryside, from stargazey pie and country churches, to man's relationship with nature and songs celebrating the patterns of the countryside (as well as ghosts and love-struck soldiers).
Microbeam MOMeNT: non-contact laser microdissection of membrane-mounted native tissue. (1997)

The analysis of tissue-specific genetic alterations depends on the selective procurement of homogeneous cell populations. Microbeam microdissection of membrane-mounted native tissue (MOMeNT) permits the rapid, selective, and low-contamination procurement of tumor or other cells from histological sections by non-thermic non-contact laser microdissection. Tissue sections are mounted on a specifically designed ultrathin transparent supporter membrane. Tissue together with the membrane are then dissected with an ultraviolet (337-nm) pulsed laser microbeam coupled into a robot-stage microscope. The ultraviolet laser causes dissection by cold photolysis due to the high photon density of the microbeam rather than by local heating. The track of the laser microbeam can be preselected freely on a video screen, and the size and form of the dissectates can thus be adapted to the histological features of the section with a delineation accuracy in the micron range. Polymerase chain reaction amplification of DNA from the dissectates is not impaired, and tumor-specific loss of heterozygosity of the APC gene as well as homozygous deletion of the MTS1 gene are demonstrated in bladder carcinomas. Taken together, microbeam MOMeNT is a novel technique that utilizes membrane-based microdissection by an ultraviolet laser microbeam, thus providing a flexible, easy-to-use high-performance tool for the molecular pathologist.
BOTH HEAT-SHOCK AND COLD-SHOCK INFLUENCE TREHALOSE METABOLISM IN AN ENTOMOPATHOGENIC NEMATODE (2005)

Heat-shock response is highly conserved in animals and microorganisms, and it results in the synthesis of heat-shock proteins. In yeast, heat-shock response has also been reported to induce trehalose accumulation. We explored the relationship between heat- (35 C) or cold-shock (1 and 10 C) and trehalose metabolism in the entomopathogenic nematode, Heterorhabditis bacteriophora. Because both heat- and cold-shocks may precede desiccation stress in natural soil environments, we hypothesized that nematodes may accumulate a general desiccation protectant, trehalose, under both situations. Indeed, both heat- and cold-shocks influenced trehalose accumulation and activities of enzymes of trehalose metabolism in H. bacteriophora. Trehalose increased by 5- and 6-fold in heat- and cold-shocked infective juveniles, respectively, within 3 hr of exposure, compared with the nematodes maintained at 25 C (culture temperature). The activity of trehalose-6-phosphate synthase (T6PS), an enzyme involved in the synthesis of trehalose, also significantly increased in both heat- and cold-shocked nematodes during the first 3 hr of exposure. Generally, the trehalose levels and activities of T6PS declined to their original levels within 3 hr when nematodes were transferred back to 25 C. In both heat- and cold-shocked nematodes, trehalase activity decreased significantly within the first 3 hr and generally returned to the original levels within 3 hr when these nematodes were transferred back to 25 C. The results demonstrate that the trehalose concentrations in H. bacteriophora are influenced by both heat- and cold-shocks and are regulated by the action of 2 trehalose-metabolizing enzymes, T6PS and trehalase. The accumulated trehalose may enhance survival of nematodes under both cold and warm conditions, but it may also provide simultaneous protection against desiccation that may result from subsequent evaporation or freezing. This is the first report of the relationship between trehalose metabolism and heat-shock for the Nematoda.
Micropump manufactured by thermoplastic molding (2002)

A micromembrane pump was manufactured by combined thermoplastic molding and membrane techniques. Pump cases were made of polyvinylidene fluoride (PVDF) and polysulfone (PSU). The mold insert was milled from a brass substrate. The lateral dimensions of the complete pump are 7 mm/spl times/10 mm. The depth and the diameter of the pump chamber are 100 /spl mu/m and 4 mm, respectively. The pump chamber is covered by a polyimide membrane 2.5 /spl mu/m thick. The inlet and outlet valves are integrated. The part of the membrane covering the pump chamber is corrugated to reduce the force needed for deflection of the membrane during pumping. The membrane is driven by an integrated thermopneumatic actuator. The air enclosed in an actuator chamber located on top of the membrane is heated by an electric current in a titanium wire. A micromembrane pump made of PSU was driven by short pulses (58 ms) of 15 V at a frequency of 5 Hz. The pump membrane was deflected 100 /spl mu/m towards the bottom of the pump chamber. The high compression ratio attained with the large membrane deflection allows gases to be pumped. A flow rate of 44 /spl mu/l/min and a differential pressure of 38 hPa was achieved. The average power consumption of the micropump was 0.45 W.
Intra prediction based on Markov process modeling of images (2013)

In our previous work, we proposed a new approach to intra prediction, in which we model image pixels with a separable first-order Markov process. The used Markov process is separable and therefore the developed method was only applied to intra prediction with vertical, horizontal and DC modes. In this paper, we extend our previous work by developing intra prediction methods based on non-separable Markov models and apply them to intra prediction along any angular direction. Compared to general linear prediction approaches, in which each block pixel is predicted using a weighted sum of all neighbor pixels of the block, the proposed approach uses much fewer independent parameters and thus offers reduced memory or computation requirements, while achieving similar coding gains.
Investigation of Galvanic-Coupled Intrabody Communication Using the Human Body Circuit Model (2014)

Intrabody Communication (IBC) is a technique that uses the human body as a transmission medium for electrical signals to connect wearable electronic sensors and devices. Understanding the human body as the transmission medium in IBC paves way for practical implementation of IBC in body sensor networks. In this study, we propose a model for galvanic coupling-type IBC based on a simplified equivalent circuit representation of the human upper arm. We propose a new way to calculate the electrode-skin contact impedance. Based on the model and human experimental results, we discuss important characteristics of galvanic coupling-type IBC, namely, the effect of tissues, anthropometry of subjects, and electrode configuration on signal propagation. We found that the dielectric properties of the muscle primarily characterize the received signal when receiver electrodes are located close to transmitter electrodes. When receiver and transmitter electrodes are far apart, the skin dielectric property affects the received signal.
Elizabethan ideas of Russia (1936)

Journal Article Elizabethan ideas of Russia Get access George B. Parks George B. Parks Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume CLXXI, Issue jul04, 4 July 1936, Pages 11–12, https://doi.org/10.1093/nq/CLXXI.jul04.11c Published: 04 July 1936
Excitation-Contraction Coupling between Human Atrial Myocytes with Fibroblasts and Stretch Activated Channel Current: A Simulation Study (2013)

Myocytes have been regarded as the main objectives in most cardiac modeling studies and attracted a lot of attention. Connective tissue cells, such as fibroblasts (Fbs), also play crucial role in cardiac function. This study proposed an integrated myocyte-I sac-Fb electromechanical model to investigate the effect of Fbs and stretch activated ion channel current (I sac) on cardiac electrical excitation conduction and mechanical contraction. At the cellular level, an active Fb model was coupled with a human atrial myocyte electrophysiological model (including I sac) and a mechanical model. At the tissue level, electrical excitation conduction was coupled with an elastic mechanical model, in which finite difference method (FDM) was used to solve the electrical excitation equations, while finite element method (FEM) was used for the mechanics equations. The simulation results showed that Fbs and I sac coupling caused diverse effects on action potential morphology during repolarization, depolarized the resting membrane potential of the human atrial myocyte, slowed down wave propagation, and decreased strains in fibrotic tissue. This preliminary simulation study indicates that Fbs and I sac have important implications for modulating cardiac electromechanical behavior and should be considered in future cardiac modeling studies.
A 35-mm format 11 M pixel full-frame CCDfor professional digital still imaging (2003)

To meet the demand for higher resolution in professional digital imaging, an 11 M pixel, 35-mm format full-frame CCD image sensor was developed as an upgrade for an existing 6 M pixel CCD. This paper presents the device requirements, the architecture, modes of operation, and extensive evaluation results.
X-Ray structures of [Cu(cyclam)(H2O)2]F2·4H2O (cyclam = 1,4,8,11-tetra-azacyclotetradecane) and [Cu(en)2(H2O)2]F2·4H2O (en = ethylenediamine) reveal [F(H2O)4]–with strong hydrogen bonds (1988)

J. Emsley, M. Arif, P. A. Bates and M. B. Hursthouse, J. Chem. Soc., Chem. Commun., 1988, 1387 DOI: 10.1039/C39880001387