gebhart/patrepeval huggingface dataset:
<title>Using CORBA to integrate manufacturing cells to a virtual enterprise</title> (1997)

It is critical in today's enterprises that manufacturing facilities are not isolated from design, planning, and other business activities and that information flows easily and bidirectionally between these activities. It is also important and cost-effective that COTS software, databases, and corporate legacy codes are well integrated in the information architecture. Further, much of the information generated during manufacturing must be dynamically accessible to engineering and business operations both in a restricted corporate intranet and on the internet. The software integration strategy in the Sandia Agile Manufacturing Testbed supports these enterprise requirements. We are developing a CORBA-based distributed object software system for manufacturing. Each physical machining device is a CORBA object and exports a common IDL interface to allow for rapid and dynamic insertion, deletion, and upgrading within the manufacturing cell. Cell management CORBA components access manufacturing devices without knowledge of any device-specific implementation. To support information flow from design to planning data is accessible to machinists on the shop floor. CORBA allows manufacturing components to be easily accessible to the enterprise. Dynamic clients can be created using web browsers and portable Java GUI's. A CORBA-OLE adapter allows integration to PC desktop applications. Other commercial software can access CORBA network objects in the information architecture through vendor API's.
Undergraduate Organic Chemistry Laboratory Safety (1996)

Each organic chemistry student should become familiar with the educational and governmental laboratory safety requirements.One method for teaching laboratory safety is to assign each student to locate safety resources for a specific class laboratory experiment.The student should obtain toxicity and hazardous information for all chemicals used or produced during the assigned experiment. For example, what is the LD50 or LC50 for each chemical? Are there any specific hazards for these chemicals, carcinogen, mutagen, teratogen, neurotixin, chronic toxin, corrosive, flammable, or explosive agent?The school's "Chemical Hygiene Plan", "Prudent Practices for Handling Hazardous Chemicals in the Laboratory" (National Academy Press), and "Laboratory Standards, Part 1910 - Occupational Safety and Health Standards" (Fed. Register 1/31/90, 55, 3227-3335) should be reviewed for laboratory safety requirements for the assigned experiment. For example, what are the procedures for safe handling of vacuum systems, if a vacuum distillation is used in the assigned experiment?The literature survey must be submitted to the laboratory instructor one week prior to the laboratory session for review and approval.The student should then give a short presentation to the class on the chemicals' toxicity and hazards and describe the safety precautions that must be followed.This procedure gives the student first-hand knowledge on how to find and evaluate information to meet laboartory safety requirements.
Identifying the Presence, Activity, and Status of Extraintestinal Manifestations of Inflammatory Bowel Disease Using Natural Language Processing of Clinical Notes (2022)

NLP methods can both detect and infer the activity status of EIMs using the medical document an information source. Though source document variation and ambiguity present challenges, NLP offers exciting possibilities for population-based research and decision support in IBD.
HIV-1 kills renal tubular epithelial cells in vitro by triggering an apoptotic pathway involving caspase activation and Fas upregulation. (1998)

HIV-infected patients suffer several renal syndromes, which can progress rapidly from renal insufficiency to end-stage renal disease. Histologically, HIV-induced nephropathy is characterized by prominent tubulopathy with apoptosis of tubular cells. Clinical and experimental evidence suggests that renal injury may be directly related to virus infection. Although HIV-1 is a polytropic and not solely lymphotropic pathogen, the susceptibility of renal cells to HIV-1 remains to be determined. This paper demonstrates in vitro the permissiveness of proximal tubular epithelial cells (PTEC) to HIV-1 and describes the effects of PTEC infection to explain the pathogenesis of tubular damage in vivo. The results indicate that PTEC express HIV-specific receptor and coreceptors and sustain virus replication. We observed that HIV-1 infection causes the death of tubular cells by triggering an apoptotic pathway involving caspase activation. Fas upregulation but not Fas ligand expression was found in the infected PTEC. However, after HIV-1 infection, tubular cells became susceptible to apoptosis induced through Fas stimulation. Caspase inhibition prevented the death of the infected PTEC in spite of persistent viral replication. These findings may explain the prominent histopathology of HIV-associated nephropathy and demonstrate that the apoptosis of nonlymphoid cells can be directly induced by HIV-1.
Shaping the Cell and the Future: Recent Advancements in Biophysical Aspects Relevant to Regenerative Medicine (2017)

In a worldwide effort to generate clinically useful therapeutic or preventive interventions, harnessing biophysical stimuli for directing cell fate is a powerful strategy. With the vision to control cell function through engineering cell shape, better understanding, measuring, and controlling cell shape for ultimately utilizing cell shape-instructive materials is an emerging “hot” topic in regenerative medicine. This review highlights how quantitation of cellular morphology is useful not only for understanding the effects of different microenvironmental or biophysical stimuli on cells, but also how it could be used as a predictive marker of biological responses, e.g., by predicting future mesenchymal stromal cell differentiation. We introduce how high throughput image analysis, combined with computational tools, are increasingly being used to efficiently and accurately recognize cells. Moreover, we discuss how a panel of quantitative shape descriptors may be useful for measuring specific aspects of cellular and nuclear morphology in cell culture and tissues. This review focuses on the mechano-biological principle(s) through which biophysical cues can affect cellular shape, and recent insights on how specific cellular “baseline shapes” can intentionally be engineered, using biophysical cues. Hence, this review hopes to reveal how measuring and controlling cellular shape may aid in future regenerative medicine applications.
Chiral capillary electrophoresis with cationic pyrrolidinium‐β‐cyclodextrin derivatives as chiral selectors (2010)

New single-isomer, cationic beta-cyclodextrins, including mono-6-deoxy-6-pyrrolidine-beta-cyclodextrin chloride (pyCDCl), mono-6-deoxy-6-(N-methyl-pyrrolidine)-beta-cyclodextrin chloride (N-CH(3)-pyCDCl), mono-6-deoxy-6-(N-(2-hydroxyethyl)-pyrrolidine)-beta-cyclodextrin chloride (N-EtOH-pyCDCl), mono-6-deoxy-6-(2-hydroxymethyl-pyrrolidine)-beta-cyclodextrin chloride (2-MeOH-pyCDCl) were synthesized and used as chiral selectors in capillary electrophoresis for the enantioseparation of carboxylic and hydroxycarboxylic acids and dansyl amino acids. The unsubstituted pyCDCl exhibited the greatest resolving ability. Most analytes were resolved over a wide range of pH from 6.0 to 9.0 with this chiral selector. In general, increasing pH led to a decrease in resolution. The effective mobilities of all the analytes were found to decrease with increasing CD concentration. The optimal concentration for most carboxylic acids and dansyl amino acid was in the range 5-7.5 mM and >15 mM for hydroxycarboxylic acids. (1)H NMR experiments provided direct evidence of inclusion in the CD cavity.
TOPSIS Method for Fuzzy Mcdm Based on Vague Set Theory (2006)

In this paper,we developed two new distance measures.According to the above discussion,a new kind of TOPSIS method about multicriteria fuzzy decision-making problem was proposed on Vague sets,which will provide a useful tool for the decision system.The method shown by an example is more advantageous in this paper.
Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer (2022)

Solid tumors are generally characterized by an acidic tumor microenvironment (TME) that favors cancer progression, therapy resistance and immune evasion. By single-cell RNA-sequencing analysis in individuals with pancreatic ductal adenocarcinoma (PDAC), we reveal solute carrier family 4 member 4 (SLC4A4) as the most abundant bicarbonate transporter, predominantly expressed by epithelial ductal cells. Functionally, SLC4A4 inhibition in PDAC cancer cells mitigates the acidosis of the TME due to bicarbonate accumulation in the extracellular space and a decrease in lactate production by cancer cells as the result of reduced glycolysis. In PDAC-bearing mice, genetic or pharmacological SLC4A4 targeting improves T cell-mediated immune response and breaches macrophage-mediated immunosuppression, thus inhibiting tumor growth and metastases. In addition, Slc4a4 targeting in combination with immune checkpoint blockade is able to overcome immunotherapy resistance and prolong survival. Overall, our data propose SLC4A4 as a therapeutic target to unleash an antitumor immune response in PDAC.
Learning Personalized End-to-End Goal-Oriented Dialog (2019)

Most existing works on dialog systems only consider conversation content while neglecting the personality of the user the bot is interacting with, which begets several unsolved issues. In this paper, we present a personalized end-to-end model in an attempt to leverage personalization in goal-oriented dialogs. We first introduce a PROFILE MODEL which encodes user profiles into distributed embeddings and refers to conversation history from other similar users. Then a PREFERENCE MODEL captures user preferences over knowledge base entities to handle the ambiguity in user requests. The two models are combined into the PERSONALIZED MEMN2N. Experiments show that the proposed model achieves qualitative performance improvements over state-of-the-art methods. As for human evaluation, it also outperforms other approaches in terms of task completion rate and user satisfaction.
Nondestructive evaluation of nuclear spent fuel dry cask structures using non-contact ACT-SLDV Lamb wave method (2020)

Since 1986, the above-ground dry cask for spent fuel rods was employed to the Surry Nuclear plant as a temporary solution for high-level waste storage until a more permanent solution could be found. During the service of the dry cask storage, when the crack occurs, it will grow progressively as time goes on. This greatly threatens the safety of the multilayer dry cask structures. Ultrasonic Lamb waves have been shown as an effective nondestructive evaluation (NDE) method due to their ability to propagate a long distance with less energy loss as well as their sensitivity to various defects on the surface or inside the structure. In this study, the research was focused on the laboratory investigation of the nondestructive inspection of the multilayer structures using a fully non-contact Lamb wave method. The non-contact system was constructed using an air-coupled transducer (ACT) for actuation and scanning laser Doppler vibrometer (SLDV) for sensing. The ACT provided a narrowband wave actuation, while SLDV provided high-quality wavefield signals for damage detection and evaluation. To systematically develop the method for dry cask structure inspection, crack inspection in a simple 1-mm aluminum plate was first conducted; then crack inspections in more complicated multilayer structures were further carried out. Besides, to evaluate the crack inspection, two imaging techniques were further developed using a full-wave energy method and a scattered wave energy method for crack detection. The cracks in both simple aluminum plate and multilayer structures were successfully inspected.
The use and misuse of curve fitting in the analysis of core X‐ray photoelectron spectroscopic data (2019)

Core X‐ray photoelectron spectroscopic (XPS) data often contain overlapping chemically shifted peaks that differ in their width, peak shape, and intensity. The spectra may be complicated by the presence of satellite and multiplet splitting features as well as from the X‐ray satellites that arise when achromatic X‐radiation is used. Curve fitting has been extensively used for more than the past 50 years as a means of extracting chemical information from the overlapping features in core XPS. Our understanding of the key components of this approach, such as the fitting function and the spectral background, has improved substantially over the years. XPS is now the most widely used surface analytical method, and many users often have their principal expertise in other areas. While the associated computer software in most XPS instruments has powerful data analysis techniques, including curve fitting, provided by the manufacturer or by a separate commercial source, the application of these techniques may not always be appropriately applied. This perspective article gives the author's view of the main issues that impact the use of curve fitting, together with a description of some approaches that misuse curve fitting leading to erroneous conclusions about the surface chemistry. The article is illustrated by examples showing the fitting of various types of spectra using true Voigt functions.
Design of Dual-band Dual-polarized MIMO Antenna for mm-wave 5G Base Stations with Octagonal Prism Structure (2019)

This paper presents design of 5G multiple input multiple output (MIMO) antenna for 5th generation (5G) base stations. The proposed antenna is dual band and it operates at millimeter-wave (mm-wave) frequencies 28 GHz and 38 GHz. It is also dual-polarized and it can switch between vertical and horizontal polarizations. The sub-array is formed of four gap-coupled microstrip slotted dual-band patch antennas with corporate microstrip feed network. The sub-array exhibits realized gain greater than 12 dBi at 28 GHz and 38 GHz and 10-dB bandwidth of around 1 GHz at 28 GHz and 38 GHz. The antenna sub-arrays are arranged on the sides of an octagonal prism to synthesize multi-beam radiation patterns with twelve sub-arrays distributed on each side of the prism. The proposed antenna has the capability of steering the pattern to particular directions by switching between antenna sub-arrays placed on either side of the prism. The proposed antenna is a good candidate for 5G base stations as it achieves polarization and pattern diversity and fulfills 5G system requirements in terms of high gain, adequate bandwidth, MIMO configuration and fixed beam-switching capability.
Battery testing at Argonne National Laboratory. Electric and hybrid propulsion systems, No. 1 (1992)

Advanced battery technology evaluations are performed under simulated electric-vehicle operating conditions at the Analysis & Diagnostic Laboratory (ADL) of Argonne National Laboratory. The ADL results provide insight into those factors that limit battery performance and life. The ADL facilities include a test laboratory to conduct battery experimental evaluations under simulated application conditions and a post-test analysis laboratory to determine, in a protected atmosphere if needed, component compositional changes and failure mechanisms. This paper summarizes the performance characterizations and life evaluations conducted during FY 1992 on both single cells and multi-cell modules that encompass six battery technologies [Na/S, Li/FeS, Ni/Metal-Hydride, Ni/Zn, Ni/Cd, Ni/Fe]. These evaluations were performed for the Department of Energy, Office of Transportation Technologies, Electric and Hybrid Propulsion Division, and the Electric Power Research Institute. The ADL provides a common basis for battery performance characterization and lie evaluations with unbiased application of tests and analyses. The results help identify the most promising R&D approaches for overcoming battery limitations, and provide battery users, developers, and program managers with a measure of the progress being made in battery R&D programs, a comparison of battery technologies, and basic data for modeling.
The role of oxytocin in shaping complex social behaviours: possible interactions with other neuromodulators (2022)

This review explores the role of oxytocin in the mediation of select social behaviours, with particular emphasis on female rodents. These behaviours include social recognition, social learning, pathogen detection and avoidance, and maternal care. Specific brain regions where oxytocin has been shown to directly mediate various aspects of these social behaviours, as well as other proposed regions, are discussed. Possible interactions between oxytocin and other regulatory systems, in particular that of oestrogens and dopamine, in the modulation of social behaviour are considered. Similarities and differences between males and females are highlighted. This article is part of the theme issue 'Interplays between oxytocin and other neuromodulators in shaping complex social behaviours'.
Surface Profilers, Multiple Wavelength, and White Light Intereferometry (2006)

This chapter contains sections titled: Introduction to Surface Profilers Contact Profilometers Optical Profilers Interferometric Optical Profilers Two Wavelength and Multiple Wavelength Techniques White Light Interference Optical Profilers Wavelength Scanning Interferometer Spectrally Resolved White Light Interferometry (SRWLI) Polarization Interferometers Optical Ranging Methods Summary
Nesiritide in Acute Decompensated Heart Failure: A Pooled Analysis of Randomized Controlled Trials (2010)

Currently available data suggest nesiritide does not significantly increase mortality at 30 or 180 days.
Advantages of water droplet machining over abrasive waterjet cutting of carbon fiber reinforced polymer (2022)

The cutting of carbon fiber reinforced polymer (CFRP) sheets with conventional tooling, such as an end-mill, results in excessive tool-wear, high-heat generation, and dust emission. Abrasive waterjet (AWJ) cutting has been used as an alternative method; however, this technique often leads to delamination of the composite material, especially around the pierce locations. Moreover, AWJ requires considerable post processing of the machined part to remove residual abrasive particles in addition to the high nozzle and conduit wear rates. A new advancement in pure waterjet cutting, Water Droplet Machining (WDM), has shown success in cutting CFRP sheets without the detrimental effects of delamination. In this paper, the results of cutting 5.5mm-thick CFRP sheet are presented using an AWJ and the WDM process. The cutting performance of the two methods is assessed based on the surface roughness of the cut edge, the presence of delamination, and the geometric accuracy of a variety of basic shapes cut from the sheet.
Extended Hemi-Hepatectomy with Portal Vein Reconstruction in a Patient with Situs Ambiguous (2008)

We report a case of far-advanced hepatocellular carcinoma (HCC) with situs ambiguous, complex visceral and vascular anomalies, who was successfully managed by extended hemi-hepatectomy. A 67-year-old man was referred to our hospital with a large liver mass. Abdominal ultrasonography, computed tomography and angiography revealed HCC with a diameter of 10 cm, with tumor thrombus in the main and first branch of the portal vein. Multiple complex anomalies in the abdomen were determined preoperatively. He had right-sided spleens-stomach-duodenum, liver at midline, inferior vena cava interruption with azygous continuation, and hepatic arterial anomaly. Extended left lobectomy of the liver with reconstruction of the portal vein was performed. Postoperatively, the patient recovered without major complications, and he was discharged on postoperative day 21. We report the first successful extended hepatectomy with portal vein reconstruction for HCC in a patient with rare situs anomalies.
Contribution of the orphan nuclear receptor Nur77 to the apoptotic action of IGFBP-3 (2007)

Tumor suppression by insulin-like growth factor-binding protein-3 (IGFBP-3) has been demonstrated to occur via insulin-like growth factor-dependent and -independent mechanisms in vitro and in vivo. We have recently described IGFBP-3-induced mitochondrial translocation of the nuclear receptors RXRalpha/Nur77 in the induction of prostate cancer (CaP) cell apoptosis. Herein, we demonstrate that IGFBP-3 and Nur77 associate in the cytoplasmic compartment in 22RV1 CaP cells. Nur77 is a major component of IGFBP-3-induced apoptosis as shown by utilizing mouse embryonic fibroblasts (MEFs) derived from Nur77 wild-type and knockout (KO) mice. However, dose-response experiments revealed that a small component of IGFBP-3-induced apoptosis is Nur77 independent. Reintroduction of Nur77 into Nur77 KO MEFs restores full responsiveness to IGFBP-3. IGFBP-3 induces phosphorylation of Jun N-terminal kinase and inhibition of Akt phosphorylation and activity, which have been associated with Nur77 translocation. Finally, IGFBP-3 administration to CaP xenografts on SCID mice induced apoptosis and translocated Nur77 out of the nucleus. Taken together, our results verify an important role for the orphan nuclear receptor Nur77 in the apoptotic actions of IGFBP-3.
Performing arts as a tool for university education during a pandemic: Moving from an in vivo to an in vitro modality (2021)

aper analyses how a course on improvisation and collective creation in engineering addressed to master’s students in Switzerland moved online. The course offers an experience in the field of performing arts, through embodied and situated activities, and the opportunity to reflect on the process of collective creation, a fundamental aspect of engineering practice often neglected in engineering training. The restrictions imposed by the 2020 pandemic forced its migration to an online format. We explore whether it is possible to maintain online a pedagogical proposal centered on embodied and face-to-face interaction, and what such a course might bring to the students. Using data collected during Spring 2020 (especially a focus group, video-recorded feedbacks and reflective diaries written by the students), we analyze the continuities and discontinuities between the two modalities. We show how the socio-material transformations im plied by the online interactions altered the interactions taking place, discuss the resultant opportunities and novelties offered by the online modality. We highlight that the apparent success of this migration to an online format overshadows the strong collective efforts needed from both students and teachers to maintain the key features of the course (playful experimentation, being inspired by others, horizontality of relations, trust, collective practice, improvisation).
The Effect of DQ-2511, a Newly Synthesized Anti-Ulcer Drug, on the Gastric Mucosal Hemodynamics and Ulceration in Rats (1989)

DQ-2511, which is a dopamine derivative, is a newly synthesized anti-ulcer drug. Pretreatment with DW-2511 in the hemorrhagic shock-reperfusion model in rats significantly prevented the decreases of gastric mucosal blood volume, mucosal blood oxygenation index and the ulcer formation. The decrease in gastric mucosal blood oxygenation index in hemorrhagic shock state has a linear correlation with the size of the mucosal ulcers both in DQ-2511 and control groups. The results suggested that DQ-2511 exerts its anti-ulcer activity by improving mucosal hemodynamics in hemorrhagic shock-reperfusion rat model.