gebhart/patrepeval huggingface dataset:
Role of enhanced receptor engagement in the evolution of a pandemic acute hemorrhagic conjunctivitis virus (2017)

Acute hemorrhagic conjunctivitis (AHC) is a painful, contagious eye disease, with millions of cases in the last decades. Coxsackievirus A24 (CV-A24) was not originally associated with human disease, but in 1970 a pathogenic "variant" (CV-A24v) emerged, which is now the main cause of AHC. Initially, this variant circulated only in Southeast Asia, but it later spread worldwide, accounting for numerous AHC outbreaks and two pandemics. While both CV-A24 variant and nonvariant strains still circulate in humans, only variant strains cause AHC for reasons that are yet unknown. Since receptors are important determinants of viral tropism, we set out to map the CV-A24 receptor repertoire and establish whether changes in receptor preference have led to the increased pathogenicity and rapid spread of CV-A24v. Here, we identify ICAM-1 as an essential receptor for both AHC-causing and non-AHC strains. We provide a high-resolution cryo-EM structure of a virus-ICAM-1 complex, which revealed critical ICAM-1-binding residues. These data could help identify a possible conserved mode of receptor engagement among ICAM-1-binding enteroviruses and rhinoviruses. Moreover, we identify a single capsid substitution that has been adopted by all pandemic CV-A24v strains and we reveal that this adaptation enhances the capacity of CV-A24v to bind sialic acid. Our data elucidate the CV-A24v receptor repertoire and point to a role of enhanced receptor engagement in the adaptation to the eye, possibly enabling pandemic spread.
1691: Sonoelastography in Evaluating Male Urethral Strictures (2007)

You have accessJournal of UrologyModerated Poster 52, Wednesday, May 23, 2007, 8:00 - 10:00 am1 Apr 20071691: Sonoelastography in Evaluating Male Urethral Strictures Michael Mitterberger, Germar M. Pinggera, Christian Gozzi, Ferdinand Frauscher, Leo Pallwein, Johann Gradl, Georg Bartsch, and Hannes Strasser Michael MitterbergerMichael Mitterberger More articles by this author , Germar M. PinggeraGermar M. Pinggera More articles by this author , Christian GozziChristian Gozzi More articles by this author , Ferdinand FrauscherFerdinand Frauscher More articles by this author , Leo PallweinLeo Pallwein More articles by this author , Johann GradlJohann Gradl More articles by this author , Georg BartschGeorg Bartsch More articles by this author , and Hannes StrasserHannes Strasser More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)31879-2AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "1691: Sonoelastography in Evaluating Male Urethral Strictures." The Journal of Urology, 177(4S), p. 561 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 177Issue 4SApril 2007Page: 561 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Michael Mitterberger More articles by this author Germar M. Pinggera More articles by this author Christian Gozzi More articles by this author Ferdinand Frauscher More articles by this author Leo Pallwein More articles by this author Johann Gradl More articles by this author Georg Bartsch More articles by this author Hannes Strasser More articles by this author Expand All Advertisement PDF downloadLoading ...
Multi-function communication terminal for home information services (2003)

A multifunction communication terminal (MFT) which can perform such functions as videotex, teletext, PC communication, mail, and so on has been developed. A book type wireless remote controller was developed for efficient utilization of these functions.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Modeling speaker-specific vocal tract kinematics from gestural scores (2021)

The theory of Task Dynamics provides a method of predicting articulatory kinematics from a discrete phonologically-relevant representation (“gestural score”). However, because the implementations of that model (e.g., Nam et al., 2004) have generally used a simplified articulatory geometry (Mermelstein et al., 1981) whose forward model (from articulator to constriction coordinates) can be analytically derived, quantitative predictions of the model for individual human vocal tracts have not been possible. Recently, methods of deriving individual speaker forward models from real-time MRI data have been developed (Sorensen et al., 2019). This has further allowed development of task dynamic models for individual speakers, which make quantitative predictions. Thus far, however, these models (Alexander et al., 2019) could only synthesize limited types of utterances due to their inability to model temporally overlapping gestures. An updated implementation is presented, which can accommodate overlapping gestures and incorporates an optimization loop to improve the fit of modeled articulatory trajectories to the observed ones. Using an analysis-by-synthesis approach, the updated implementation can be utilized: (1) to refine the hypothesized speaker-general gestural parameters (target, stiffness) for individual speakers; (2) to test different degrees of temporal overlapping among multiple gestures such as a CCVC syllable. [Work supported by NSF, Grant 1908865.]
Development of AlGaN/GaN heterostructures for e-beam pumped UV lasers (2021)

Here, we present the design and fabrication of AlGaN/GaN heterostructures that constitute the active element of electron-beam pumped UV lasers. The design of multi-quantum-well separate confinement heterostructures (SCHs) and graded-index separate confinement heterostructures (GRINSCHs) was adapted based on Monte Carlo simulations of the electron penetration depth. The structures were synthesized by plasma-assisted molecular beam epitaxy on bulk GaN substrates, and validated using transmission electron microscopy and X-ray diffraction. Mirror facets were fabricated by cleaving. Cathodoluminescence studies prove the benefits of the GRINSCH design in terms of carrier collection efficiency. The threshold power density under optical pumping with an Nd-YAG laser (266 nm) was below 200 kW/cm<sup>2</sup> at room temperature.
Case Ellipsis Resolution in Japanese Dialogues via Decision-Tree Learning (1999)

機械翻訳では目的言語で必須格となる格の人称と数を補う必要がある。本論文では、省略補完知識の決定木による表現、及び帰納的に機械学習することによって日本語対話文の格要素省略を補完する手法を提案する。本研究では形態素分割され、品詞、省略情報が付与された任意のコーパスとシソーラスのみを用いて行なう。決定木学習には、内容語の意味属性、機能語の出現、言語外情報の3種類の属性を使用する。未学習文に対してテストを行なった結果、ガ、ヲ、ニの三つの格で照応的な省略の補完を十分な精度で行なうことができた。またガ格と二格に対しては人称と数の補完にも有効であることを確認した。ガ格に関して、処理の有効性を学習量、話題依存性、使用属性との関係の三点から実験し、以下の知見が得られた。 (1) 当該問題に対する決定木学習量は全体として104～105事例で十分である。この時の補完精度の上限は80%～85%と予想される。 (2) 対話の話題が既知もしくは予測可能な時は、その話題のみのコーパスによる学習が最善である。話題が未知の場合は、可能な限り広範な話題に対して学習するのが最も効果的である。 (3) 学習量増加に伴い、決定木には機能語などの話題に依存しない属性が多く採用される。
Can higher cutting speeds and temperatures improve the microstructural surface integrity of advanced Ni-base superalloys? (2022)

Future Ni-base superalloys are designed to deliver outstanding mechanical behaviour at high temperatures, which may translate in significant machining challenges. In this work, a paradigm is presented by which is proven how machining of these materials could benefit from increased cutting speeds and temperatures provided that they are able to promote shear localisation and thermal softening in the chip deformation zones, whilst retaining high-temperature strength within the machined surface. In this way, thermal control of chip formation leads to both lower cutting forces and energies, as well as enhanced surface integrity with lower levels of microstructural reconfiguration.
Dysfunctional dendritic cells limit antigen-specific T cell response in glioma (2022)

Glioma-associated DCs are relevantly abundant in human IDHwt and mutant tumors. Glioma IDH mutations result in specifically educated, dysfunctional DCs via paracrine reprogramming of infiltrating monocytes, providing the basis for combinatorial immunotherapy concepts against IDH mutant gliomas.
Normalized Apparent Diffusion Coefficient in the Prognostication of Patients with Glioblastoma Multiforme (2016)

The survival of patients with GBM had small, but significant, correlations with the patient's age and nADC within the tumor.
Etude in vivo de la capacité de flottabilité de mini-comprimés contenant de la riboflavine sur des volontaires sains humains (2005)

info:eu-repo/semantics/published
A Physiological Flow Model for the Gastrointestinal Absorption and Plasma Kinetics of Aspirin (Transdermal Drug Delivery, Pharmacokinetics). (1986)

A compartmental model for the absorption and distribution of oral solutions of aspirin has been developed. Compartments for the stomach, duodenum, jejunum ileum, portal system, liver and plasma have been included. This is an improvement over earlier models for drug absorption, in which flow in the gut and the estimation of plasma levels have seldom been combined. Plasma compartment concentrations predicted for rat, dog and man are in agreement with reported aspirin levels. A technique called modal analysis (Palsson, B. O. and Lightfoot, E. N., J. Theo. Bio., 111: 273 - 302) was used to reduce the number of differential equations in the model and to identify the critical model parameters. This analysis indicated that gastric emptying is theoretically the rate limiting process in absorption for all three species. Dynamics in the plasma compartment were also critical in determining simulation results. The model has been used to predict the differences between aspirin concentrations in the portal and peripheral veins. Achieving high portal versus peripheral concentrations may be important to the therapeutic success of aspirin as an antiplatelet agent. The ratio of the simulated peak portal compartment concentration to the simulated peak plasma (peripheral) compartment concentration was ten times greater for a dose delivered as a bolus to the jejunum than for a similar dose delivered to the stomach. This result was qualitatively confirmed by experiments in rats. Dosage forms which release aspirin in the jejunum rather than the stomach are therefore postulated to provide more effective antiplatelet activity.
Olanzapine (2013)

Our review suggests that the likelihood of a favorable response with olanzapine is maximized at doses of 10 to 15 mg/d (perhaps lower in nonsmoking females). Higher doses may be considered if 15 mg is ineffective and if plasma level is less than 20 ng/mL on that dose. There is a direct linear relationship between olanzapine dose and plasma concentration. Therapeutic drug monitoring may be useful in patients who are suspected of nonadherence, where there is potential for a drug interaction, and in patients taking 15 mg/d or more and who have not reached clinical response.
Defining a Digital Twin-based Cyber-Physical Production System for autonomous manufacturing in smart shop floors (2019)

Smart manufacturing is the core idea of the fourth industrial evolution. For a smart manufacturing shop floor, real-time monitoring, simulation and prediction of manufacturing operations are vital to improve the production efficiency and flexibility. In this paper, the Cyber-Physical System (CPS) and Digital Twin technologies are introduced to build the interconnection and interoperability of a physical shop floor and corresponding cybershop floor. A Digital Twin-based Cyber-Physical Production System (DT-CPPS) is further established, and the configuring mechanism, operating mechanism and real-time data-driven operations control of DT-CPPS are discussed in detail. It is expected that DT-CPPS will provide the basis for shop floors to march towards smart manufacturing.
MIMO OFDM Physical Layer Real-Time Prototyping (2008)

Emerging wireless communication systems are rapidly moving toward Multiple-Input Multiple-Output (MIMO) technologies to guarantee either robustness and throughput as required by current broadband applications. Targeting a solution easy to integrate, MIMO technology can be conveniently adopted in combination with the largely known Orthogonal Frequency Division Multiplexing (OFDM), a modulation scheme combining high spectral efficiency with low complexity. MIMO and OFDM are the Physical (PHY) layer technologies selected by IEEE to drive the evolution of current Wireless-LAN 802.11 standards. Starting from a template architecture definition, a flexible MIMO W-LAN PHY layer based on IEEE 802.11n draft standard has been implemented and validated on a commercial FPGA-based prototyping platform embedding RF cards to prove on-air real-time capabilities. The overall RTL design has been then synthesized for the STMicroelectronics CMOS low-power 65 nm technology.
Mild and severe salt stress responses are age-dependently regulated by abscisic acid in tomato (2022)

Salt stress hampers plant growth and development through both osmotic and ionic imbalances. One of the key players in modulating physiological responses towards salinity is the plant hormone abscisic acid (ABA). How plants cope with salinity largely depends on the magnitude of the soil salt content (stress severity), but also on age-related developmental processes (ontogeny). Here we studied how ABA directs salt stress responses in tomato plants for both mild and severe salt stress in leaves of different ages. We used the ABA-deficient mutant <i>notabilis</i>, which contains a null-mutation in the gene of a rate-limiting ABA biosynthesis enzyme 9-cis-epoxycarotenoid dioxygenase (NCED1), leading to impaired stomatal closure. We showed that both old and young leaves of <i>notabilis</i> plants keep a steady-state transpiration and photosynthesis rate during salt stress, probably due to their dysfunctional stomatal closure. At the whole plant level, transpiration declined similar to the wild-type, impacting final growth. <i>Notabilis</i> leaves were able to produce osmolytes and accumulate ions in a similar way as wild-type plants, but accumulated more proline, indicating that osmotic responses were not impaired by the <i>NCED1</i> mutation. Besides <i>NCED1</i>, also <i>NCED2</i> and <i>NCED6</i> are strongly upregulated under salt stress, which could explain why the <i>notabilis</i> mutant did not show a lower ABA content upon salt stress, except in young leaves. This might be indicative of a salt-mediated feedback mechanism on <i>NCED2/6</i> in <i>notabilis</i> and might explain why <i>notabilis</i> plants seem to perform better under salt stress compared to wild-type plants with respect to biomass and water content accumulation.
Antibodies to GAD and Tryptic Fragments of Islet 64K Antigen as Distinct Markers for Development of IDDM: Studies With Identical Twins (1992)

Insulin-dependent diabetes mellitus (IDDM) is associated with antibodies to a 64,000-M(r) islet cell protein, at least part of which is identified as glutamic acid decarboxylase (GAD). These antibodies are detected as two distinct antibody specificities to 50,000-M(r) and 37,000/40,000-M(r) tryptic fragments of the autoantigen (50K and 37K antibodies, respectively). We determined the frequencies of antibodies to intact GAD, tryptic fragments of islet 64,000-M(r) antigen, islet cell antibodies (ICAs), and insulin autoantibodies (IAAs) in sera from 58 nondiabetic identical twins of patients with IDDM, of whom 12 subsequently developed diabetes. ICA, antibodies to intact GAD, and those to tryptic fragments were detected at similar frequencies in prediabetic twins (67-75%), but only 25% had IAA. Of 46 twins who remain nondiabetic, GAD antibodies, 50K antibodies, and ICA were detected in 6 (13%), 7 (15%), and 5 (11%), respectively, whereas only 1 (2%) possessed 37K antibodies and 2 (4%) had IAA. Eight of 9 twins with 37K antibodies and all 6 twins with ICA greater than 20 Juvenile Diabetes Foundation U have developed diabetes. Antibodies to GAD are sensitive markers for diabetes development but may also be present in genetically susceptible individuals who are unlikely to develop disease. Antibodies to 37,000/40,000-M(r) fragments of the 64,000-M(r) antigen or high-titer ICA were the best markers for diabetes development in these twins.
Narrow Single Implants with a Reduced Platform (3.0) for the Resolution of Punctual Horizontal Atrophies in the Canine and Premolar Area: Case Series (2023)

Introduction: Severe unitary atrophies in the horizontal direction make the direct insertion of dental implants difficult. Block grafting or guided bone regeneration in small sites is also complex, sometimes requiring a highly predictable option. The insertion of small-platform, low-diameter implants can be a safe and effective alternative for these sites, even on a single-unit basis. In the following article we present a series of cases rehabilitated with these implants. Material and Methods: Patients with horizontal atrophy of a tooth requiring the insertion of a single implant in the premolar and canine area were recruited, and 3 mm platform implants with a diameter of 3.3 mm were placed between May 2018 and December 2019 in a dental clinic in Vitoria, Spain. Marginal crestal bone loss was calculated by measuring from the implant shoulder to the first site where bone-to-implant contact was evident. The reference for comparing the radiographic records and thus estimating the bone loss produced in each of the patients was the radiograph taken at the time of prosthesis insertion. Qualitative variables were described by frequency analysis. Quantitative variables were described by means of mean and standard deviation. Implant survival was calculated using the Kaplan- Meier method. Result: Eight patients were recruited and eight 3.0 implants were placed in the canine and premolar region in a unitary form with a diameter of 3.3 mm. All implants were rehabilitated in a unitary form, in two phases, using a screw-retained prosthesis with unitary transepithelial. The mean follow-up time was 39.8 months (+/- 18). Survival of the implants studied was 100% and of the prostheses as well. The mean mesial crestal bone loss of the implants studied was 0.77 mm (+/- 0.01) and distal bone loss was 0.35 mm (+/- 0.7). Conclusions: Implants with a reduced diameter and platform can be used as a unit provided that a correct surgical and prosthetic treatment plan is followed, analysing the case as a whole and individualising the approach for each patient.
Evaluation of Japanese Beetle Adulticides on Grape Foliage, 198 (1983)

Abstract Six insecticide treatments were screened for efficacy against the Japanese beetle on potted 'Seyval' grapes at Wooster, OH. The potted vines were transported from the greenhouse to a sodfield, highly infested with adult beetles just prior to treatment. A treatment consisted of 10 vines, 5 replicates, each containing 2 vines in a randomized block design. A single application was made Jul 8. Two methods of application were utilized, a C0„ constant pressure sprayer and a Herbi Micron ultra low-volume applicator. The CO. sprayer equipped with a TeeJet 9505E fan-type nozzle was operated at 40 psi to deliver 4 of the treatments at the rate of 50 dal/acre. The remaining treatments were applied with the Herbi at the rate of 0.5 gal water/acre. Treatments were evaluated through bioassay at 3 different periods post application. Leaves (2) were removed from treated plants and their petioles were placed in floral tubes. These leaves were in turn placed in 1-gal ice cream cartons with 10 Japanese beetles collected in an untreated area. The cartons had been modified by placing a 16-mesh wire screen over the bottom and cheese cloth over the top. The insect holding room was maintained at 75 F with 80 + 5% RH under a 16-hr photoperiod.
Data from Nitric Oxide Induces Early Viral Transcription Coincident with Increased DNA Damage and Mutation Rates in Human Papillomavirus–Infected Cells (2023)

&lt;div&gt;Abstract&lt;p&gt;High-risk human papillomavirus (HPV) infections are necessary but insufficient causes of cervical cancers. Other risk factors for cervical cancer (e.g., pregnancy, smoking, infections causing inflammation) can lead to high and sustained nitric oxide (NO) concentrations in the cervix, and high NO levels are related to carcinogenesis through DNA damage and mutation. However, the effects of NO exposure in HPV-infected cells have not been investigated. In this study, we used the NO donor DETA-NO to model NO exposure to cervical epithelium. In cell culture media, 24-hour exposure to 0.25 to 0.5 mmol/L DETA-NO yielded a pathologically relevant NO concentration. Exposure of cells maintaining episomal high-risk HPV genomes to NO increased HPV early transcript levels 2- to 4-fold but did not increase viral DNA replication. Accompanying increased E6 and E7 mRNA levels were significant decreases in p53 and pRb protein levels, lower apoptotic indices, increased DNA double-strand breaks, and higher mutation frequencies when compared with HPV-negative cells. We propose that NO is a molecular cofactor with HPV infection in cervical carcinogenesis, and that modifying local NO cervical concentrations may constitute a strategy whereby HPV-related cancer can be reduced.[Cancer Res 2009;69(11):4878–84]&lt;/p&gt;&lt;/div&gt;
A Survey of Vehicle to Everything (V2X) Testing (2019)

Vehicle to everything (V2X) is a new generation of information and communication technologies that connect vehicles to everything. It not only creates a more comfortable and safer transportation environment, but also has much significance for improving traffic efficiency, and reducing pollution and accident rates. At present, the technology is still in the exploratory stage, and the problems of traffic safety and information security brought about by V2X applications have not yet been fully evaluated. Prior to marketization, we must ensure the reliability and maturity of the technology, which must be rigorously tested and verified. Therefore, testing is an important part of V2X technology. This article focuses on the V2X application requirements and its challenges, the need of testing. Then we also investigate and summarize the testing methods for V2X in the communication process and describe them in detail from the architectural perspective. In addition, we have proposed an end-to-end testing system combining virtual and real environments which can undertake the test task of the full protocol stack.
RFIDice - Augmenting Tabletop Dice with RFID (2024)

Augmented dice allow players of tabletop games to have the result of a roll be automatically recorded by a computer, e.g., for supporting strategy games. We have built a set of three augmented-dice-prototypes based on radio frequency identification (RFID) technology, which allows us to build robust, cheap, and small augmented dice. Using a corresponding readout infrastructure and a sample application, we have evaluated our approach and show its advantages over other dice augmentation methods discussed in the literature.
Safe Local Navigation for Visually Impaired Users With a Time-of-Flight and Haptic Feedback Device (2018)

This paper presents ALVU (Array of Lidars and Vibrotactile Units), a contactless, intuitive, hands-free, and discreet wearable device that allows visually impaired users to detect low- and high-hanging obstacles, as well as physical boundaries in their immediate environment. The solution allows for safe local navigation in both confined and open spaces by enabling the user to distinguish free space from obstacles. The device presented is composed of two parts: a sensor belt and a haptic strap. The sensor belt is an array of time-of-flight distance sensors worn around the front of a user's waist, and the pulses of infrared light provide reliable and accurate measurements of the distances between the user and surrounding obstacles or surfaces. The haptic strap communicates the measured distances through an array of vibratory motors worn around the user's upper abdomen, providing haptic feedback. The linear vibration motors are combined with a point-loaded pretensioned applicator to transmit isolated vibrations to the user. We validated the device's capability in an extensive user study entailing 162 trials with 12 blind users. Users wearing the device successfully walked through hallways, avoided obstacles, and detected staircases.