gebhart/patrepeval huggingface dataset:
Side effects and its prevention in anticancer treatment. (2002)

Anticancer drugs have been developing, and side effects of those drugs should be prevented. Many kinds of side effects have been reported, but we do not predict them. Side effects, including cardiac toxicity, nephrotoxicity, and neurotoxicity are known. As DNA microarray techniques has been developed well it is now applicable to predict side effects using single nucleotide polymorphism (SNP). To prevent side effects, development of new drugs or novel drug delivery system will provide us possibilities for future. Monoclonal antibodies or tyrosine kinase inhibitors are novel modalities to predict efficacy and side effects. Drug resistance or infusion-related syndrome has to be analyzed, For instances, CD 13 is a molecule that degrades the N-terminal residues of endothelial interleukin-8 and will be resistant to apoptotic signal. In this case we add CD 13 inhibitor, such as ubenimex, and it will give us a new therapy to treat CD 13-positive leukemia cells. Such research will be important to circumvent resistance or side effects. Liposome technologies for doxorubicin or cisplatin will give us less side effects. Small molecules that interferes cell cycle will be researched quickly.
Linear-Input Logic (1961)

Techniques are developed for the logical design of magnetic core circuits to produce arbitrary single-output combinational switching functions. The approach is based on the relationship of a single magnetic core circuit to a linearly separable switching function. A synthesis procedure is developed which uses a pair of logical primitives, AND with NOT and OR with NOT, which are similar to the STROKE primitive and its inverse. Procedures are developed for the synthesis of symmetric functions which require no more than the integral part of (n+3)/2 cores, approximately half the number used in previously published procedures. The synthesis of arbitrary switching circuits is treated as a linear programming problem, and a table of all four-variable circuits is presented in which no circuit requires more than three cores.
Characterization, chromosomal mapping, and expression of different polyubiquitin genes in tissues from control and heat-shocked maize seedlings (1995)

Polyubiquitin transcripts accumulate in plant and animal cells following a heat shock. Most species have a few to several polyubiquitin genes; within a species, the genes may differ in nucleotide (nt) sequence and (or) the number of 228-nt repeats encoding the ubiquitin monomer. This study examines three maize (inbred Oh43) polyubiquitin genes. Two of the genes, MubG9 and MubG5, possess five repeats; the third, MubG1 possesses seven repeats. Sequence analyses of the genomic clones, MubG9 and MubG1 and a cDNA clone, MubG5, reveal that they differ primarily from each other in their nt sequences 5′ and 3′ to their open reading frames. MubG1 contains a 1004-base pair (bp) intron in its 5′ untranslated region. Using gene-specific probes, we show that the amount of polyribosome-associated mRNA transcripts from MubG9 isolated from 2- and 5-day old plumules and radicles is unchanged by heat shock. While the amount of transcript from MubG1 and MubG5 on the polyribosomes in plumules and radicles of 2-day-old seedlings is also unchanged by heat shock, the levels of these transcripts are elevated considerably in similar tissues from heat-shocked 5-day-old seedlings. Similar or identical gene-specific probes were employed to map the genes using the recombinant inbred method. MubG9 maps to chromosome 4L position 186; MubG1 maps to 5L104 and MubG5 to 4L188. The opportunity to use gene-specific probes extends the evidence for distinct modulation (time and tissue) of polyubiquitin gene expression in maize and provides the basis for locus assignment within the genome.Key words: ubiquitin, maize, heat shock, heat-shock proteins, gene expression, chromosome map.
State of Water, Molecular Structure, and Cytotoxicity of Silk Hydrogels (2011)

A novel technique was developed to regulate the bulk water content of silk hydrogels by adjusting the concentrations of silk proteins, which is helpful to investigate the effects of the state of water in polymeric hydrogel on its biological functions, such as cytotoxicity. Gelation of the silk hydrogel was induced with ethanol and its gelation behavior was analyzed by rheometry. The silk hydrogels prepared at various silk concentrations were characterized with respect to their water content, molecular and network structures, state of water, mechanical properties, and cytotoxicity to human mesenchymal stem cells. The network structure of silk hydrogel was heterogeneous with β-sheet and fibrillar structures. The influence of the state of water in the silk hydrogel on the cytotoxicity was recognized by means of differential scanning calorimetry and cell proliferation assay, which revealed that the bound water will support cell-adhesion proteins in the cellular matrix to interact with the surface of the silk hydrogels.
Clinical and radiographic evaluation of small‐diameter (3.3‐mm) implants followed for 1–7 years: a longitudinal study (2006)

Implants with a small diameter may be used where bone width is reduced or in single-tooth gaps with limited mesiodistal space, such as for the replacement of lateral maxillary or mandibular incisors. The purpose of the present longitudinal study was to compare the prognosis of narrow implants (3.3-mm-diameter) to standard (4.1-mm-diameter) implants. Over a 7-year period, 122 narrow implants were inserted in 68 patients to support 45 partial fixed prostheses (PFD) and 23 single-tooth prostheses (ST). Furthermore, 120 patients received 208 standard implants and were restored with 70 PFD and 50 ST, respectively. Clinical and radiographic assessment data were provided. Six (1.8%) out of 330 implants failed. Cumulative survival and success rates were calculated with life-table analyses processed by collecting clinical and radiographic data. For narrow implants, the cumulative survival rate was 98.1% in the maxilla and 96.9% in the mandible. The cumulative success rate was 96.1% in the maxilla and 92% in the mandible. Conversely, standard-diameter implants showed a cumulative survival rate of 96.8% in the maxilla and 97.9% in the mandible. The cumulative success rate was 97.6% in the maxilla and 93.8% in the mandible. Cumulative survival and success rates of small-diameter implants and standard-diameter implants were not statistically different (P > 0.05). Type 4 bone was a determining failure factor, while marginal bone loss was not influenced by the different implant diameters. The results suggest that small-diameter implants can be successfully used in the treatment of partially edentulous patients.
Gene Expression Profiling Predicts the Development of Oral Cancer (2011)

Patients with oral premalignant lesion (OPL) have a high risk of developing oral cancer. Although certain risk factors, such as smoking status and histology, are known, our ability to predict oral cancer risk remains poor. The study objective was to determine the value of gene expression profiling in predicting oral cancer development. Gene expression profile was measured in 86 of 162 OPL patients who were enrolled in a clinical chemoprevention trial that used the incidence of oral cancer development as a prespecified endpoint. The median follow-up time was 6.08 years and 35 of the 86 patients developed oral cancer over the course. Gene expression profiles were associated with oral cancer-free survival and used to develop multivariate predictive models for oral cancer prediction. We developed a 29-transcript predictive model which showed marked improvement in terms of prediction accuracy (with 8% predicting error rate) over the models using previously known clinicopathologic risk factors. On the basis of the gene expression profile data, we also identified 2,182 transcripts significantly associated with oral cancer risk-associated genes (P value < 0.01; univariate Cox proportional hazards model). Functional pathway analysis revealed proteasome machinery, MYC, and ribosomal components as the top gene sets associated with oral cancer risk. In multiple independent data sets, the expression profiles of the genes can differentiate head and neck cancer from normal mucosa. Our results show that gene expression profiles may improve the prediction of oral cancer risk in OPL patients and the significant genes identified may serve as potential targets for oral cancer chemoprevention.
Active Devices for Power Electronics: SiC vs III-N Compounds – The Case of Schottky Rectifiers (2010)

The main rectifier device structures for power electronics based on SiC and on GaN are compared and the main issues for each structure are evaluated in terms of performance and manufacturability. The driving volume markets for power electronics devices correspond to the systems working on 127, 240 and 400 V energy supply networks, setting the device voltage handling to 300, 600, and 1200V respectively. We have limited the scope hereafter to the 600 V typical target, for which SiC Schottky rectifiers are now commercially available from at least 3 sources. The key physical properties for any semiconductor material used as the active layer of a unipolar device for power electronics are the breakdown field and carriers mobility. The bulk values are very similar for SiC and GaN. Two main other key issues are related to quality of the ohmic and Schottky contacts. For the ohmic contacts, adequate solutions have been found for both SiC and GaN. Surprisingly, on hetero-epitaxial GaN layers on sapphire despite of the very high crystal defects density ( ≥ 109cm-2 ), the ideality factor of the best Schottky contacts seems very promising. On the other hand, improving this ideality factor and the reverse leakage current for Schottky contacts on GaN layers grown on silicon substrate remains a fierce challenge. For the SiC Schottky rectifiers, cost and availability of the SiC substrates appear as the main residual limiting factors today. For GaN based rectifiers, although engineering device prototypes have already been published [1], there are both basic issues to be validated regarding reverse leakage current and reliability, and also difficult manufacturing issues to be solved in relation with device reliability, directly resulting from the nature of the possible substrates: mainly sapphire and silicon.
Front Matter (2013)

The prelims comprise: Title Copyright Table of Contents Preface Lead Editors Editorial Team
Global identifiability of linear compartmental models-a computer algebra algorithm (1998)

A priori global identifiability deals with the uniqueness of the solution for the unknown parameters of a model and is, thus, a prerequisite for parameter estimation of biological dynamic models. Global identifiability is however difficult to test, since it requires solving a system of algebraic nonlinear equations which increases both in nonlinearity degree and number of terms and unknowns with increasing model order. In this paper, a computer algebra tool, GLOBI (GLOBal Identifiability) is presented, which combines the topological transfer function method with the Buchberger algorithm, to test global identifiability of linear compartmental models. GLOBI allows for the automatic testing of a priori global identifiability of general structure compartmental models from general multi input-multi output experiments. Examples of usage of GLOBI to analyze a priori global identifiability of some complex biological compartmental models are provided.
Synthesis, Structure, and Catalytic Oxidation Chemistry from the First Oxo−Imido Schiff Base Metal Complexes (2004)

The molybdenum oxo-imido complex, [Mo(O)(NtBu)Cl2(dme)] (1), was obtained from the reaction between [MoO2Cl2(dme)] and [Mo(NtBu)2Cl2(dme)]. Reactions between [Mo(O)(NR)Cl2(dme)] (where R = tBu or 2,6-iPr2C6H3) and the disodium Schiff base compounds Na(2)(3,5-tBu2)2salen, Na(2)(3,5-tBu2)2salpen, and Na(2)(7-Me)2salen afforded the first oxo-imido transition metal Schiff base complexes: [Mo(O)(NtBu)[(3,5-tBu2)2salen]] (2), [Mo(O)(NtBu)[(3,5-tBu2)2salpen]] (3), and [Mo(O)(N-2,6-iPr2C6H3)[(7-Me)2salen]] (4), respectively. The compounds [Mo(NtBu)2[(3,5-tBu2)2salpen]] (5) from [Mo(NtBu)2(NHtBu)2] and [Mo(N-2,6-iPr2C6H3)(2)[(7-Me)2salen]](6) from [Mo(N-2,6-iPr2C6H3)(2)(NHtBu)2] (7) are also reported. Compounds 1-7 were characterized by NMR, IR, and FAB mass spectroscopy while compounds 3, 4, and 5 were additionally characterized by X-ray crystallography. In conjunction with tBuOOH as oxidant, compound 3 is a catalyst for the oxidation of benzyl alcohol to benzaldehyde and cis-cyclooctene and 1-octene to the corresponding epoxides.
The Spastic Mouse (1990)

An animal model of chronic spasticity would be valuable. There has been little success at producing such a model, however, because there is no frequently occurring natural disease in animals and, after experimental injury, the animals tend to die or recover. Spasticity in animals or humans is one of the many manifestations of an upper motor neuron syndrome; there is no such thing as pure spasticity. Spasticity in animals and humans involves abnormal functions at many levels of the neurologic and muscular systems. Animal models of spasticity may not be directly applicable to human spasticity, because the animal brain is so different from the human brain. Genetically spastic mice are a homogeneous population that have an abnormally functioning neurotransmitter within the central nervous system. This model has been shown to develop abnormalities of muscle growth that ultimately lead to contracture. The spastic mouse shows some promise for investigation of the abnormalities of muscles and joints that occur in spastic humans.
The Synthesis of Azaoxaspirane Steroid Alkaloids1 (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Synthesis of Azaoxaspirane Steroid Alkaloids1Frederick C. UhleCite this: J. Am. Chem. Soc. 1961, 83, 6, 1460–1472Publication Date (Print):March 1, 1961Publication History Published online1 May 2002Published inissue 1 March 1961https://pubs.acs.org/doi/10.1021/ja01467a045https://doi.org/10.1021/ja01467a045research-articleACS PublicationsRequest reuse permissionsArticle Views371Altmetric-Citations48LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Retrospective Detection of Laboratory Cross-Contamination of Mycobacterium tuberculosis Cultures with Use of DNA Fingerprint Analysis (1997)

In 1992-1993, we investigated possible cross-contamination of Mycobacterium tuberculosis cultures as part of a study of tuberculosis in Arkansas by using DNA fingerprint analysis. Of patients whose isolates were matched, those for whom smears were negative and only one culture was positive were identified from laboratory records. Clinical, laboratory, DNA fingerprint, and epidemiological data were reviewed. Of 259 patients, nine (3.5%) were judged to be due to cross-contamination. None of these patients had a clinical course consistent with tuberculosis. All nine specimens were processed with another isolate with a matching DNA fingerprint, and epidemiological connections were not identified among any of the patients. To avoid erroneous diagnoses and unnecessary therapy and public health investigations, specimens from patients with tuberculosis whose smears are negative and only one culture is positive should be investigated for cross-contamination. An inconsistent clinical course and a DNA fingerprint that matches those of other culture-positive specimens processed concurrently, coupled with the lack of an epidemiological connection, suggest cross-contamination.
Applications of Silk (1993)

Modern interest in silk started in the late 1960's with the first extensive mechanical property examination by Zemlin in 1968 (1). Today, the same unique balance of material properties, good tensile strength, elasticity, and resistance to fracture is the primary driving mechanism behind the continuing interest in silks. Supercontraction, the mechanical response of some silks to moisture, has also been identified as being of potential technological value (2-4). It is well known that the diverse primary and secondary structure of silk fibers is the basis from which some of their physical properties arise. Through interactions between and modifications of these structures to respond to specific chemical and mechanical environments, the spider tailors the properties of a particular silk for each specific application. It is this control of properties that we hope to better understand. Gosline stated it well in a recent interview (5): "We do not aim to copy nature
Efficient algorithms for memory management in embedded vision systems (2016)

In the field of embedded vision systems, meeting the constraints on design criteria such as performance, area, and power consumption can be a real challenge. In fact, to alleviate the well known “Memory Mall”, it is mandatory to provide efficient memory hierarchies to reach usable performance for the system to be designed when it has to handle non-linear image treatments. To address this problematic, Mancini and Rousseau (Proc.DATE, 2012) have designed a software generator of memory hierarchies for each non-linear image operation. It allows one to improve dramatically the performance of the system, while moderately increasing its area and energy consumption. The trade-offs between these three parameters are then taken to the level of the design of the operation of this memory hierarchy, a problem that can be formalized as a 3-objective optimization problem. In this study, we formalize this problem and give new approaches both for the problem and particular sub-problems. The results on the same real-world data set as used by Mancini and Rousseau (Proc.DATE, 2012) show a very significant improvement and reduce the amount of transferred data up to 30% and a reduction of the computing time up to 15%.
Highly ordered FePd and FePt nanostructures (2006)

In the present study we show two variations of the bottom-up approach. First our correlated structural and magnetic properties studies on epitaxial FePd films grown on (001) MgO will show that this particular system does exhibit perpendicular magnetic anisotropy and it is also nano-structured due to 3-dimensional growth mode on the chosen substrate. We also note here that the highly-ordered nanostructures embedded in the chemically disordered alloy film are magnetically coupled. We found that capping the films with a thin MgO layer significantly lowers interparticle coupling. For the FePt system we have used ion-implantation of Fe ions on epitaxial Pt films followed by rapid thermal treatments. We have achieved controlled nano-patterning, large perpendicular magnetic anisotropy and decoupled highly ordered nano-structures. We present our correlated structural (XRD, AFM, TEM) and magnetic (MFM, Kerr magnetometry) characterizations on the two systems studied. Our observations are useful to further understand magnetic anisotropy properties at the nano-scale for new media applications.
A hybrid algorithm for the point to multipoint routing problem (1997)

Article Free Access Share on A hybrid algorithm for the point to multipoint routing problem Authors: Heather L. Christensen Mathematical and Computer Sciences Dept, The University of Tulsa, 600 South College Avenue, Tulsa, OK Mathematical and Computer Sciences Dept, The University of Tulsa, 600 South College Avenue, Tulsa, OKView Profile , Roger L. Wainwright Mathematical and Computer Sciences Dept, The University of Tulsa, 600 South College Avenue, Tulsa, OK Mathematical and Computer Sciences Dept, The University of Tulsa, 600 South College Avenue, Tulsa, OKView Profile , Dale A. Schoenefeld Mathematical and Computer Sciences Department, The University of Tulsa, 600 South College Avenue, Tulsa, OK Mathematical and Computer Sciences Department, The University of Tulsa, 600 South College Avenue, Tulsa, OKView Profile Authors Info & Claims SAC '97: Proceedings of the 1997 ACM symposium on Applied computingApril 1997 Pages 263–268https://doi.org/10.1145/331697.331751Published:01 April 1997Publication History 5citation340DownloadsMetricsTotal Citations5Total Downloads340Last 12 Months5Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Target Localization Using Instrumental Variable Method in Sensor Network (2013)

An instrumental variable (IV) based linear estimator is proposed for effective target localization in sensor network by using time-difference-of-arrival (TDOA) measurement. Although some linear estimation approaches have been proposed in much literature, the target localization based on TDOA measurement still has a room for improvement. Therefore, we analyze the estimation errors of existing localization estimators such as the well-known quadratic correction least squares (QCLS) and the robust least squares (RoLS), and demonstrate advantages of the proposition by comparing the estimation errors mathematically and showing localization results through simulation. In addition, a recursive form of the proposition is derived to consider a real time application.
YAP establishes epiblast responsiveness to inductive signals for germ cell fate (2021)

The germ cell lineage in mammals is induced by the stimulation of pluripotent epiblast cells by signaling molecules. Previous studies have suggested that the germ cell differentiation competence or responsiveness of epiblast cells to signaling molecules is established and maintained in epiblast cells of a specific differentiation state. However, the molecular mechanism underlying this process has not been well defined. Here, using the differentiation model of mouse epiblast stem cells (EpiSCs), we have shown that two defined EpiSC lines have robust germ cell differentiation competence. However, another defined EpiSC line has no competence. By evaluating the molecular basis of EpiSCs with distinct germ cell differentiation competence, we identified YAP, an intracellular mediator of the Hippo signaling pathway, as crucial for the establishment of germ cell induction. Strikingly, deletion of YAP severely affected responsiveness to inductive stimuli, leading to a defect in WNT target activation and germ cell differentiation. In conclusion, we propose that the Hippo/YAP signaling pathway creates a potential for germ cell fate induction via mesodermal WNT signaling in pluripotent epiblast cells.