gebhart/patrepeval huggingface dataset:
Physical and mechanical properties of iron-aluminium-(Mn, Si) lightweight steels (2000)

Iron-aluminium alloys containing up to 9 wt- for the development of high performance lightweight steels for automotive applications and for building constructions. Some of these alloys have a b.c.c. structure and have interesting physical and mechanical properties. Macro-alloying with manganese favours the formation of the austenite phase. Micro-alloying and thermomechanical processing including texture development will improve the plastic anisotropy properties and the strain hardening exponent.
Sustainable mobility for tourists at the Dutch Coastal Islands (Waddeneilanden) (2010)

The European Coastal Islands around the North sea, are joined together in a project that stimulates sustainable development. Within this 'Cradle-to-Cradle Islands' project, some islands were selected as breading grounds for potentially sustainable projects. One of these projects was the development of a device for transport: the Vrachtfiets. A Vrachtfiets is a modular electric-assisted, two person, cargo-bicycle that enables the creation of custom made mobility solutions. The design of the Vrachtfiets includes a Product-Service System (PSS) as an integral solution to both local transport needs and transport needs to and from the island Ameland Currently, the majority of the tourist families take their cars to the island (by ferry), since the hassle of carrying luggage is too much to use the public transport system (local busses). For these tourists, a PSS has been designed that provides them with an alternative to transport themselves, their family and their luggage between the ferry and the holiday park without a car. This reduces the amount of cars on Ameland, saves tourists their money and creates a unique and fun experience. Eco-Costs and the Eco-Costs/Value Ratio (EVR) have been used to assess the sustainability of the Vrachtfiets PSS. It can be concluded that approximately 90 Vrachtfiets movements can be made for each car movement in terms of Eco-Costs. EVR calculations indicate that the value based eco-efficiency is around 16 times better, compared to tourists using cars. PSS and C2C aspects were taken into account.
Key Role of the Endothelial TGF-β/ALK1/Endoglin Signaling Pathway in Humans and Rodents Pulmonary Hypertension (2014)

Mutations affecting transforming growth factor-beta (TGF-β) superfamily receptors, activin receptor-like kinase (ALK)-1, and endoglin (ENG) occur in patients with pulmonary arterial hypertension (PAH). To determine whether the TGF-β/ALK1/ENG pathway was involved in PAH, we investigated pulmonary TGF-β, ALK1, ALK5, and ENG expressions in human lung tissue and cultured pulmonary-artery smooth-muscle-cells (PA-SMCs) and pulmonary endothelial cells (PECs) from 14 patients with idiopathic PAH (iPAH) and 15 controls. Seeing that ENG was highly expressed in PEC, we assessed the effects of TGF-β on Smad1/5/8 and Smad2/3 activation and on growth factor production by the cells. Finally, we studied the consequence of ENG deficiency on the chronic hypoxic-PH development by measuring right ventricular (RV) systolic pressure (RVSP), RV hypertrophy, and pulmonary arteriolar remodeling in ENG-deficient (Eng+/-) and wild-type (Eng+/+) mice. We also evaluated the pulmonary blood vessel density, macrophage infiltration, and cytokine expression in the lungs of the animals. Compared to controls, iPAH patients had higher serum and pulmonary TGF-β levels and increased ALK1 and ENG expressions in lung tissue, predominantly in PECs. Incubation of the cells with TGF-β led to Smad1/5/8 phosphorylation and to a production of FGF2, PDGFb and endothelin-inducing PA-SMC growth. Endoglin deficiency protected mice from hypoxic PH. As compared to wild-type, Eng+/- mice had a lower pulmonary vessel density, and no change in macrophage infiltration after exposure to chronic hypoxia despite the higher pulmonary expressions of interleukin-6 and monocyte chemoattractant protein-1. The TGF-β/ALK1/ENG signaling pathway plays a key role in iPAH and experimental hypoxic PH via a direct effect on PECs leading to production of growth factors and inflammatory cytokines involved in the pathogenesis of PAH.
Simulation und Animation (2009)

In zunehmendem Maße werden bei der Rekonstruktion und Analyse von Straßenverkehrsunfällen komplexe Rechenprogramme eingesetzt. Damit in Verbindung stehen neue Fachbegriffe und Verständigungsprobleme zwischen den Experten und den Empfängern von Gutachten.
Molecular interaction of cytotoxic anticancer analogues as inhibitors of β -tubulin protein against UACC-62 melanoma cell (2020)

In previous research, a series of cytotoxic anticancer analogues related to 2-acylamino-1,4-naphthoquinone derivatives has been demonstrated. As microtubule plays an important role in many essential cellular processes such as mitosis, tubulin is an important target of anticancer drug. This study performed molecular docking simulation, pharmacophore model, comparative force field analysis model and comparative similarity indices analysis model to investigate the relationship between inhibitory activities and the properties of compounds, in order to further progress the development of cytotoxic anticancer analogues. These compounds have common H-bond interactions with key residues Lys254 and Lys352, but compounds with large R2 substituent have different docking poses than compounds with small R2 substituent. Some of derivatives such as compound 18 formed the H-bonds with residue Lys254 using the oxygen atoms in R1 substituent and formed π-cation interactions with residue Lys352 using phenyl moiety of 1,4-naphthoquinone. The R1 substituent of these compounds preferred to have disfavoured hydrophobic fields and favourable space towards the direction of residue Asn258, while the R2 substituent of these compounds preferred to have about 2-3 carbon chain length hydrophobic substituent towards the direction of residues Ala316 and Lys352. These results offer some beneficial advices for further study in anticancer drug development process.
Applications of Microtube Array on Transflective Liquid Crystal Displays for Backlight Efficiency Enhancement (2004)

A novel transflective liquid crystal display (LCD) with a microtube array structure to make the most effective use of backlight was demonstrated. By redefining the area ratio of transmissive and reflective regions, high light efficiency in both transmissive and reflective subpixels can be attained. Based on the principle of light collection, a simulation model was established to characterize the features and optimize the microtube array structure. Furthermore, a typical TFT-LCD process was utilized to fabricate the optimized structure. A prototype microtube array was fabricated, and the measured enhancement of backlight utilization efficiency can be as high as a factor of 1.81.
Recombinant humanized anti‐CD40 monoclonal antibody triggers autologous antibody‐dependent cell‐mediated cytotoxicity against multiple myeloma cells (2003)

Multiple myeloma (MM) is currently incurable, and novel therapies are needed. In this study, we examined a novel recombinant humanized monoclonal antibody against CD40 (rhuCD40 mAb) and demonstrate for the first time that rhuCD40 mAb induces antibody-dependent cell-mediated cytotoxicity (ADCC) against CD40-positive MM cells. Importantly, we show that rhuCD40 mAb induces autologous ADCC against primary patient MM cells, without triggering ADCC against normal B cells. This study, therefore, both demonstrates that rhuCD40 mAb triggers autologous ADCC against patient MM cells and provides the framework for the clinical evaluation of rhuCD40 mAb immunotherapy to improve patient outcome in MM.
Tn2001, a transposon encoding chloramphenicol resistance in Pseudomonas aeruginosa (1981)

We isolated a new transposon, Tn2001, from the group P-2 plasmid Rms159-1 in Pseudomonas aeruginosa. Tn2001-encoded chloramphenicol resistance did not result from the formation of chloramphenicol acetyltransferase. Tn2001 was transposable between temperate phages and conjugative and nonconjugative plasmids belonging to various incompatibility groups, including P-1, P-3, P-4, P-5, P-7, and P-8 in P. aeruginosa. Transposition occurred independently of the general recombination ability of the Pseudomonas host, and its frequency varied between 10(-1) and 10(-8), depending upon the donor and recipient replicons. Tn2001 transposition also occurred in a recombination-deficient strain of Escherichia coli. Agarose gel electrophoresis and electron microscopic observations revealed that Tn2001 could transpose to different sites in the RP4 replicon and that the transposed deoxyribonucleic acid fragment was 2.1 kilobases long.
Cost-optimal data retrieval for video servers with variable bit rate video streams (1998)

We consider the problem of data retrieval from disk storage in a video server where the data is stored in constant size blocks. The two critical resources of a video server are the amount of disk I/O bandwidth and the main memory buffer required to support a video stream. We propose a new algorithm that allows us to determine the cost-optimal trade-off between these two server resources as well as bounds and statistics of the start-up latency seen by the user. Keywords -- Video Server, disk storage, continuous media, VBR video, retrieval. 1 Introduction Video servers store digitized, compressed, continuous media information on secondary or tertiary storage. The secondary storage devices allow random access and provide short seek times compared to tertiary storage. Video server design differs significantly from that of traditional data storage servers due to the large size of the objects stored and the real-time requirements for their retrieval. A video server must meet the requirement...
Two-dimentional Transition-metal Dichalcogenide Nanocomposites as Novel Enzyme Mimics: An Overview (2018)

Nanozyme is a very exciting and promising field that aims to imitate the general principles of natural enzymes using various nanomaterials and offers a lot of practical applications in many areas. Natural enzyme has some intrinsic drawbacks such as high cost, low stability, difficulty in storage, and sensitivity of catalytic activity towards enviromental conditions. While, nanozyme demonstrates low cost, high stability and high efficient activity. Great progress has been achieved by various peroxidase and/or oxidase mimetics, This brief overview introduce the latest research progresses for two-dimentional transition-metal dichalcogenide nanocomposites as promising enzyme mimics.
A Canada-wide survey of chronic respiratory disease and spinal cord injury (2015)

These heightened odds highlight the exigent need for targeted interventions and prevention strategies for respiratory health among individuals with SCI.
Brain-Sparing sympathofacilitators mitigate obesity without adverse cardiovascular effects (2020)

To read the full abstract: Cell Metab. 2020 Jun 2;31(6):1120-1135.e7. doi: 10.1016/j.cmet.2020.04.013.
Gene expression measurements in the context of epidemiological studies (2008)

Collecting blood samples into tubes containing an RNA-stabilizing solution increases RNA yield and reduces its variability. Long-term storage of samples may lead to RNA degradation, requiring special attention in longitudinal studies.
Abstract 950: Merkel cell polyomavirus infection in cutaneous squamous cell carcinomas (2011)

Abstract Objective: Merkel cell polyomavirus (MCV) DNA has been reported previously in 0-25% of squamous cell carcinomas (SCC) occurring in immunocompetent individuals. No studies have investigated MCV seroreactivity in individuals with SCC. We conducted a clinic-based case-control study to investigate the association between MCV seroreactivity and SCC, overall and stratified by MCV DNA status of the SCC tumor tissue. Methods: Patients with histologically-confirmed cutaneous SCC (n=173) were recruited from a university dermatology clinic. Controls were patients undergoing skin cancer screening exams who screened negative for and had no history of skin or other cancers (n=300). Levels of antibodies against capsid antigens for MCV and other polyomavirus controls (JC virus (JCV) and KI virus (KIV)) were determined by fluorescent bead-based multiplex serology. Fresh-frozen tumor tissues were obtained from 145 SCC cases, and DNA from six polyomaviruses (MCV, JCV, KIV, WU virus (WUV), BK virus (BKV) and simian virus 40 (SV40)) was measured using multiplexed PCR. Polyomavirus seropositivity, based on binary cutpoints, and quartiles of seroreactivity, based on the control distribution, were compared between SCC cases and controls, overall and stratified by the presence or absence of MCV DNA in SCC tumor tissues. Associations were estimated by calculating odds ratios (OR) and 95% confidence intervals (CI) using logistic regression to adjust for age, sex, and skin reaction to the sun. Results: MCV seropositivity was associated with a statistically significant increased risk of SCC (OR=1.80, 95% CI=1.03-3.12), whereas no association was observed for JCV (OR=1.17, 95% CI=0.72-1.92) or KIV (OR=0.88, 95% CI=0.37-2.09) seropositivity. MCV DNA was detected in 55 (38%) of SCC tumor tissues, whereas all tissues were negative for DNA from the other five polyomaviruses. Using controls as the reference group, MCV DNA-positive SCC cases were three times as likely to be MCV seropositive (OR=3.15, 95% CI=1.11-8.92) and almost six times as likely to have MCV antibody levels in the fourth versus first quartile (OR=5.94, 95% CI=1.79-19.74, ptrend=0.001). No associations were observed between MCV seropositivity and MCV DNA-negative SCC (OR=1.40, 95% CI=0.78-2.77) or between JCV or KIV seropositivity and MCV DNA-negative or DNA-positive SCC. Conclusion: SCC patients were significantly more likely than controls to exhibit MCV seroreactivity, particularly if they had MCV DNA in their SCC tumor tissue. This association was specific to MCV, with no associations observed for the other polyomaviruses studied. These results suggest that past exposure to MCV may be a risk factor for SCC in immunocompetent individuals. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 950. doi:10.1158/1538-7445.AM2011-950
A numerical method for general finite amplitude wave propagation in two dimensions and its application to spark pulses (1991)

The general equations of finite amplitude acoustics, including classical absorption effects and second-order nonlinear effects, are written in a form suitable for two-dimensional numerical solution. A finite difference scheme then is applied to numerically solve the equations. To demonstrate the method, examples are given of spherical free-field propagation, normal plane reflection from a hard surface, and oblique spherical reflection from a hard surface for spark pulses. This method has an advantage over Burgers’ equation methods, one-way wave equation methods, and Pestorius type algorithms in that it can predict the interaction of multiple finite amplitude acoustic waves at arbitrary propagation angles.
Computed tomography of the normal and pathologic muscular system. (1980)

A standard program of computed tomographic (CT) scanning of the human skeletal muscular system was developed. Scans were obtained on five levels: the neck, the shoulder girdle, the pelvic girdle, the thigh, and the lower leg. The normal size and density of several muscles were determined. CT scans were also obtained in patients with various neuromuscular diseases. Several types of lesions were found, and their morphologic descriptions and quantitative data are presented. It is concluded that CT opens new possibilities for the evaluation of muscular atrophy and hypertrophy.
Quality Assessments of Long-Term Quantitative Proteomic Analysis of Breast Cancer Xenograft Tissues (2017)

Clinical proteomics requires large-scale analysis of human specimens to achieve statistical significance. We evaluated the long-term reproducibility of an iTRAQ (isobaric tags for relative and absolute quantification)-based quantitative proteomics strategy using one channel for reference across all samples in different iTRAQ sets. A total of 148 liquid chromatography tandem mass spectrometric (LC-MS/MS) analyses were completed, generating six 2D LC-MS/MS data sets for human-in-mouse breast cancer xenograft tissues representative of basal and luminal subtypes. Such large-scale studies require the implementation of robust metrics to assess the contributions of technical and biological variability in the qualitative and quantitative data. Accordingly, we derived a quantification confidence score based on the quality of each peptide-spectrum match to remove quantification outliers from each analysis. After combining confidence score filtering and statistical analysis, reproducible protein identification and quantitative results were achieved from LC-MS/MS data sets collected over a 7-month period. This study provides the first quality assessment on long-term stability and technical considerations for study design of a large-scale clinical proteomics project.
RAMINO - A KNOWLEDGE BASED SYSTEM AND A CO-ORDINATOR OF NUMERICAL MODELS FOR STRUCTURAL RELIABILITY ASSESSMENT (1991)

This paper reports on the application of expert systems technology to the estimation and management of reliability and residual lifetime of complex structures, in particular of offshore structures. The aim of the work undertaken is to improve the efficiency in structural maintenance. This involves designing informatic tools to assist the inspection experts. These informatic tools include traditional numerical programmes, computational models and an expert system. The main aim of this paper is to present the philosophy behind the synthesis of these tools, the adopted methodology, the specially designed expert system architecture and the domain expert elicitation.
License to Run: Exercise Impacts Functional Plasticity in the Intact and Injured Central Nervous System by Using Neurotrophins (2005)

Exercise has been found to impact molecular systems important for maintaining neural function and plasticity. A characteristic finding for the effects of exercise in the brain and spinal cord has been the up-regulation of brain-derived neurotrophic factor (BDNF). This review focuses on the ability of exercise to impact brain circuitry by promoting neuronal repair and enhance learning and memory by increasing neurotrophic support. A paragon for the role of activity-dependent neurotrophins in the CNS is the capacity of BDNF to facilitate synaptic function and neuronal excitability. The authors discuss the effects of exercise in the intact and injured brain and spinal cord injury and the implementation of exercise preinjury and postinjury. As the CNS displays a capacity for plasticity throughout one's lifespan, exercise may be a powerful lifestyle implementation that could be used to augment synaptic plasticity, promote behavioral rehabilitation, and counteract the deleterious effects of aging.
P353 Structural, functional, and electromechanical alterations in patients with paroxysmal atrial fibrillation compared to healthy controls (2020)

Abstract Background and Methods We sought to evaluate the clinical and echocardiographic differences between healthy controls and paroxysmal atrial fibrillation (AF) patients. Clinical and echocardiographic parameters (performed in sinus rhythm) in 46 paroxysmal AF patients were compared with a departmental database of 83 health controls. Results AF patients were older and had increased body size (Table 1). 39/46 (84%) of AF patients had hypertension and 23/46 (50%) had diabetes mellitus. AF patients had increased left ventricular (LV) mass, and reduced diastolic function (lower e’ and increased E/e’ ratio) when compared to healthy controls. Left atrial (LA) volumes were significantly increased in the AF group. All strain parameters – reservoir, conduit, and contractile strain – were impaired in AF patients compared to controls. LA mechanical dispersion (MD) was significantly increased in AF patients. A ratio of indexed LA volume/LA reservoir strain was significantly higher in AF patients over controls. The duration of AF had an inverse correlation with LA reservoir strain (Fig 1) (r=–0.78; p &amp;lt; 0.001). Conclusions Compared to healthy controls, patients with paroxysmal AF have significant structural, functional and electromechanical alterations. LA strain is significantly impaired in paroxysmal AF and correlates with AF duration. Table 1. Echocardiographic parameters Parameter Controls (mean ± SD) AF patients (mean ± SD) P value Age (years) 48 ± 18 58 ± 14 0.001 Body surface area (m2) 1.9 ± 0.2 2 ± 0.2 0.014 LV mass (g) 178 ± 48 223 ± 68 &amp;lt;0.001 Average e’ velocity (cms-1) 10.3 ±2.7 8.1 ± 2.2 &amp;lt;0.001 E/e’ 7.4 ± 1.9 9.3 ± 3.4 0.001 Indexed LA end systolic volume (ml/m2) 27.2 ± 7.1 39.0 ± 11.6 &amp;lt;0.001 LA ejection fraction 55.2 ± 10.4 48.5 ± 14.0 0.007 LA functional index 43.7 ± 14.6 29.8 ± 14.3 &amp;lt;0.001 LA reservoir strain (%) 34.3 ± 6.8 27.9± 8.1 &amp;lt;0.001 LA conduit strain (%) 18.4 ± 6.2 13.5 ± 4.7 &amp;lt;0.001 LA contractile strain (%) 15.9 ± 3.9 14.4 ± 5.5 0.007 LA mechanical dispersion (ms) 25.8 ± 9.6 30.9 ± 11.6 0.018 Indexed LA volume / Reservoir strain ratio 0.8 ± 0.3 1.6 ± 0.9 &amp;lt;0.001 LV = left ventricular; LA = left atrium; SD = standard deviation Abstract P353 Figure. Fig 1. AF duration vs. Reservoir strain
Intake of Mercury From Fish, Lipid Peroxidation, and the Risk of Myocardial Infarction and Coronary, Cardiovascular, and Any Death in Eastern Finnish Men (1995)

These data suggest that a high intake of mercury from nonfatty freshwater fish and the consequent accumulation of mercury in the body are associated with an excess risk of AMI as well as death from CHD, CVD, and any cause in Eastern Finnish men and this increased risk may be due to the promotion of lipid peroxidation by mercury.
Regulation of cAMP-mediated gene transcription by wild type and mutated G-protein alpha subunits. Inhibition of adenylyl cyclase activity by muscarinic receptor-activated and constitutively activated G(o) alpha. (1994)

We have used a luciferase reporter gene under the transcriptional control of a cAMP response element (CRE) to monitor the effects of G-protein alpha subunits on cAMP-regulated gene expression and to examine muscarinic acetylcholine receptor (mAChR) functional coupling to G-proteins. Expression in JEG-3 cells of a mutationally activated Gi alpha-2 in which glutamine 205 is replaced with leucine (Q205L) decreased forskolin-stimulated expression from the CRE-luciferase gene by up to 75%. Similarly, mutation of glycine 43 (corresponding to glycine 12 in p21ras) to valine decreased forskolin-stimulated expression from the CRE-luciferase gene by a maximum of 50%, indicating that this mutation activates the G-protein and is potentially oncogenic. Transfection of the activated Q205L G(o) alpha subunit decreased forskolin stimulation of CRE-luciferase expression. Transfected wild type G(o) alpha was also able to couple the m4 mAChR receptor to inhibition of AC. The amino-terminal myristoylation site was removed from wild type Gi alpha-2 and Q205L Gi alpha-2 by changing glycine 2 to alanine (G2A). Gi alpha-2 with the G2A and Q205L mutations was unable to decrease forskolin stimulation of CRE-mediated luciferase activity. Furthermore, G2A Gi alpha-2 was unable to couple the m4 mAChR to inhibition of AC. Thus, myristoylation is required both for the function of constitutively active Q205L Gi alpha-2 and for receptor-mediated activation of wild type Gi alpha-2.
Influence of cell growth upon D-glucose metabolism in pancreatic islet cells (1993)

info:eu-repo/semantics/published