gebhart/patrepeval huggingface dataset:
Sonography: A Method for Localization of Hematomas in Hemophiliacs (1976)

Sonography was used to visualize hematomas in hemophilic patients. The method is especially helpful for the diagnosis of psoas hematoma and retroperitoneal hematoma and allows the follow-up of hematomas of the cervical region and muscle hematomas. The method is simple, rapid, painless and has no known adverse effects.
Nouvelles interfaces numériques : enjeux de lutherie et création musicale (2016)

International audience
Editorial: Volume II: Tumor microenvironment in cancer hallmarks and therapeutics (2023)

EDITORIAL article Front. Mol. Biosci., 28 March 2023Sec. Molecular Diagnostics and Therapeutics Volume 10 - 2023 | https://doi.org/10.3389/fmolb.2023.1182083
Combined bilateral lung resections and off-pump coronary artery bypass grafting. (2002)

We report herein a 74 year old man with angina who had an abnormal chest roentgenogram. Computed tomography of the chest showed a solitary 1.0-cm peripheral, noncalcified lesion in the apical segment of the left lower lobe and a 1.5-cm peripheral lesion in the posterior basal segment of the right lower lobe. Coronary angiography revealed the left anterior descending coronary artery to have a long 90% stenosis. We report here a case of a combined bilateral lung resection and off-pump coronary surgery though a midline sternotomy in a compromised lung function patient with both severe coronary artery disease and bilateral synchronous primary lung cancer.
ChemInform Abstract: N‐ALLYL ANALOGS OF PHENCYCLIDINE: CHEMICAL SYNTHESIS AND PHARMACOLOGICAL PROPERTIES (1985)

Abstract Auf zwei Synthesewegen erhält man über die Verbindungen (IV) die Allylamine (VII).
Sequence-Specific Retention Calculator. A Family of Peptide Retention Time Prediction Algorithms in Reversed-Phase HPLC:  Applicability to Various Chromatographic Conditions and Columns (2007)

Separation selectivity of C18 reversed-phase columns from different manufacturers has been compared to evaluate the applicability of our sequence-specific retention calculator (SSRCalc) peptide retention prediction algorithms. Three different versions of SSRCalc are currently in use: 300-A pore size sorbents (TFA as ion-pairing modifier, pH 2), 100 A (TFA, pH 2), and 100 A (pH 10), which have been applied for the separation of randomly chosen mixture of tryptic peptides. The major factor affecting separation selectivity of C18 sorbents was found to be apparent pore size, while differences in end-capping chemistry do not introduce a significant impact. The introduction of embedded polar groups to the C18 functionality increases the retention of peptides containing hydrophobic amino acid residues with polar groups: Tyr and Trp. We also demonstrate that changing the ion-pairing modifier to formic/acetic acid significantly reduces the algorithm's predictive ability, so models developed for different eluent conditions cannot be compared directly to each other.
Environmental Risk Factors Predisposing to the Development of Basal Cell Carcinoma (2004)

BACKGROUND Basal cell carcinomas (BCCs) are the most common malignancies in white people. The incidence varies depending on the region of the world, with the highest rate of 1% to 2% per year noted in Australia. It is estimated that BCC incidence increases by 5% annually. An increasing incidence of BCC is in line with the changes in the living style and exposure to various environmental factors. OBJECTIVE To present the environmental factors that may influence the development of BCCs. The influence of ultraviolet radiation exposure alone and in connection with immunosuppression, smoking, occupational factors, as well as arsenic and ionizing radiation exposure, was described. CONCLUSION BCC is a very complex disease, with many factors influencing its development. Environmental factors are very important for the prevalence of BCC, and most of them can be avoided. The exposure to ultraviolet radiation is undoubtedly of great risk; therefore, the national campaigns against aggressive, seasonal sun exposure, especially in children and adolescents, as well as using sunscreens, are of great value in the fight against BCC development.
Novel electro-optical techniques in metrology (1976)

Members of the Lanchester Polytechnic Electrical Engineering Department have made a gauging device that uses new electro-optical techniques. To engineer the techniques into a usable device, many problems had to be overcome. This article reports how it was done, and also reports present and future work using the techniques
A novel approach to code analysis of digital signal processing systems (2001)

We present a technique for program analysis targeting digital signal processing systems. It is utilized by the FRIDGE design environment to transform floating-point systems into fixed-point systems. While the transforming algorithms have been subject to a number of other publications, we now put the focus on the novel technique of program analysis employed by FRIDGE. The code is analyzed by interpreting it without processing any concrete input data. This enables most accurate analysis even capable of detecting dynamic code properties without relying on input vectors as e. g. profilers do.
Effects of Nanomolar to Submillimolar Carteolol on Noradrenaline Release in the Absence and Presence of Uptake1 and Uptake2 Blockers in Guinea Pig Pulmonary Arteries. (1992)

Effects of nanomolar to submillimolar carteolol, a non-selective beta-antagonist, on the evoked release at 1 Hz and the spontaneous release in the absence and presence of uptake1 and uptake2 blockers were studied in pulmonary arteries, isolated from guinea pigs, and then preloaded with [3H]noradrenaline. dl-Carteolol at 10(-8), 10(-7) and 10(-6) M applied at the increasing concentrations inhibited the evoked [3H]-release in untreated arteries and in desipramine and corticosterone-treated arteries. The spontaneous [3H]-release slightly but significantly increased or tended to increase in untreated arteries. dl-Carteolol at 10(-5) and 10(-4) M clearly and concentration-dependently increased the spontaneous [3H]-release in untreated and cocaine-treated arteries. This increase was markedly inhibited by further pretreatment with normetanephrine. The evoked [3H]-release was not altered by dl-carteolol at 10(-5) M, but increased at 10(-4) M. This increase was not modified by cocaine and by cocaine and normetanephrine. d-Carteolol at 10(-5) and 10(-4) M produced effects similar to those of dl-carteolol. Nanomolar to micromolar dl-carteolol inhibits the evoked [3H]-release, which supports our previous conclusion that this inhibition is due to blockade of tonically functioning presynaptic beta 2-adrenoceptors. Carteolol at the higher concentrations seems to become a substrate for an uptake2 mechanism and to produce an unknown sympathomimetic activity in guinea pig pulmonary arteries.
Human anti-MUC1 antibodies elicited by a prophylactic cancer vaccine for CAR T cell immunotherapy. (2016)

Abstract Hypoglycosylated MUC1 is a tumor-associated protein that is expressed on over 80% of all human cancers including adenocarcinomas of the colon, pancreas, breast, lung, prostate, and ovary, and multiple myeloma. In our recent clinical trial, individuals at-risk for colon adenocarcinoma received a prophylactic MUC1 cancer vaccine. Many individuals responded producing high titers of anti-MUC1 IgG antibodies with no detectable toxicity. This trial provided a rare source of human antibodies elicited and affinity-matured in a healthy human host to abnormal MUC1. Using our recently developed proteomics method, we isolated and identified 13 anti-MUC1 antibodies representing 7 different clonotypes. These antibodies bind to several different epitopes on the MUC1 vaccine peptide with a range of affinities (15.7μM to 130pM). They also stain MUC1 on human cancer cell lines and colon, breast, lung, and pancreas adenocarcinoma tissue sections while showing no reactivity against a large panel of normal tissues that express MUC1. We constructed lentiviral vectors encoding chimeric antigen receptors (CARs) using scFv’s of several of the antibodies as antigen binding regions and a variety of co-signaling domain architectures. Several of the scFv’s were able to retarget human primary T cells to become activated and produce cytokines in a MUC1-dependent manner and to lyse a variety of MUC1+ human tumor cell lines. Preclinical testing in mouse tumor xenograftgrafts is underway. Being of fully human origin and showing a high-degree of tumor specificity and efficacy in preclinical experiments, these antibodies will be tested in future clinical trials for potential approval for therapy of cancer patients.
The effect of turbulence and acoustic waves on underwater acoustic propagation (2006)

The primary objective of this study was to develop a predictive methodology for received signal variation as a function of ocean perturbations using a ray-based analysis of the effects of internal waves and ocean turbulence on underwater acoustic propagation. In the present formulation the eikonal equations are considered in the form of a second-order, nonlinear ordinary differential equation with harmonic excitation due to an internal wave. The harmonic excitation is taken imperfect, i.e., with a random phase modulation due to Gaussian white noise, accounting for both chaotic and stochastic behavior. Small scale and geostrophic turbulence are represented using the potential theory two-wave-number model for a vortex array. The focus is to numerically study the influence of these fluid velocity and sound speed fluctuations and the role of initial ray angle on underwater acoustic propagation to provide a realistic characterization of acoustic arrivals. Predicted arrival behavior is analyzed using ray trace, time-front, and phase plots for varying initial conditions. Regions of instability are identified using bifurcation and phase diagrams. This work leads to understanding how turbulence and internal waves affect sound transmission and utilizes the statistics of received signals to identify fluid mechanic phenomena that occurred along the sound channel.
ANALYZING AND PREDICTING CAT BOND PREMIUMS: A FINANCIAL LOSS PREMIUM PRINCIPLE AND EXTREME VALUE MODELING (2017)

Abstract CAT bonds play an important role in transferring insurance risks to the capital market. It has been observed that typical CAT bond premiums have changed since the recent financial crisis, which has been attributed to market participants being increasingly risk averse. In this work, we first propose a new premium principle, the financial loss premium principle, which includes a term measuring losses in the financial market that we represent here by the Conditional Tail Expectation (CTE) of the negative daily log-return of the S&amp;P 500 index. Our analysis of empirical evidence suggests indeed that in the post-crisis market, instead of simply increasing the fixed level of risk load universally, the increased risk aversion should be modeled jointly by a fixed level of risk load and a financial loss factor to reflect trends in the financial market. This new premium principle is shown to be flexible with respect to the confidence/exceedance level of CTE. In the second part, we focus on the particular example of extreme wildfire risk. The distribution of the amount of precipitation in Fort McMurray, Canada, which is a very important factor in the occurrence of wildfires, is analyzed using extreme value modeling techniques. A wildfire bond with parametric trigger of precipitation is then designed to mitigate extreme wildfire risk, and its premium is predicted using an extreme value analysis of its expected loss. With an application to the 2016 Fort McMurray wildfire, we demonstrate that the extreme value model is sensible, and we further analyze how our results and construction can be used to provide a design framework for CAT bonds which may appeal to (re)insurers and investors alike.
The Biological Flora of Coastal Dunes and Wetlands: Chamaecrista chamaecristoides (Colladon) I. & B. (1998)

Chamaecrista chamaecristoides (Colladon) I. & B. is a tropical shrubby legume endemic to the Mexican coastal sand dunes of the Gulf of Mexico and to a lesser extent, of the Pacific coast. It grows mainly on mobile dunes, and it is the first colonizer. In this study we present information regarding the plant's geographical distribution, range of habitats, physiological ecology, population biology, reproduction, its role in geomorphology and interactions with other species. Ch. chamaecristoides is very tolerant to drought and low nutrient availability in the soil. Biomass accumulation and relative growth rates increase significantly when seedlings are covered by sand. The legume may be considered as a nurse plant that modifies environmental conditions and facilitates the successional process. Temperature fluctuations in the shade of adult plants decrease noticeably when compared with bare sand temperatures. Further, bacterial and mycorrhizal associations are abundant. All these characteristics probably play an important role in dune dynamics since late colonizers are only able to arrive after Ch. chamaecristoides has reached a rather high (2x2m) plant cover. The plant's hard coated seeds germinate gradually throughout the year, after seeds have been exposed to naturally occurring temperature fluctuations on the sand surface. Seedling mortality is very high during the first three months, and only 5% reach adult stage. Winter storms are a major cause of death, since drought and sand movement become drastic during these months (November to March). We found that seedling size plays an important role in survival and reproduction. Larger seedlings are the ones with higher survival rates and reproduce earlier. Ch. chamaecristoides plants decrease sand movement and hold the substrate together, promoting dune stabilization. This is important to humans, since mobile dunes continuously encroach nearby roads, cities and crop fields. There is no practical experience in dune stabilization with this species.
62‐4L: Late‐News Paper : A Circular Flexible AMOLED Display with a 1‐mm Slim Border (2016)

A 1.26″ circular plastic‐based AMOLED display has been developed for wearable application. By locating gate drivers in the active area and expending active area outside the circuit area of the panel, we successfully realized a display with true circular shape and 1mm slim border, respectively.
Molecular imaging of inflammation and intraplaque vasa vasorum: A step forward to identification of vulnerable plaques? (2010)

Current developments in cardiovascular biology and imaging enable the noninvasive molecular evaluation of atherosclerotic vascular disease. Intraplaque neovascularization sprouting from the adventitial vasa vasorum has been identified as an independent predictor of intraplaque hemorrhage and plaque rupture. These intraplaque vasa vasorum result from angiogenesis, most likely under influence of hypoxic and inflammatory stimuli. Several molecular imaging techniques are currently available. Most experience has been obtained with molecular imaging using positron emission tomography and single photon emission computed tomography. Recently, the development of targeted contrast agents has allowed molecular imaging with magnetic resonance imaging, ultrasound and computed tomography. The present review discusses the use of these molecular imaging techniques to identify inflammation and intraplaque vasa vasorum to identify vulnerable atherosclerotic plaques at risk of rupture and thrombosis. The available literature on molecular imaging techniques and molecular targets associated with inflammation and angiogenesis is discussed, and the clinical applications of molecular cardiovascular imaging and the use of molecular techniques for local drug delivery are addressed.
Congestion Exposure (ConEx) Concepts and Abstract Mechanism (2010)

This document describes an abstract mechanism by which senders inform
the network about the congestion encountered by packets earlier in the
same flow. Today, the network may signal congestion to the receiver by
ECN markings or by dropping packets, and the receiver may pass this
information back to the sender in transport-layer feedback. The
mechanism to be developed by the ConEx WG will enable the sender to
also relay this congestion information back into the network in- band
at the IP layer, such that the total level of congestion is visible to
all IP devices along the path, from where it could, for example, be
provided as input to traffic management.
Resolving two point targets with unequal and unknown Intensities in a FPA (2021)

This paper presents a method of determining whether two closely spaced objects observed by an electro-optical (EO) sensor are resolvable. The first goal of this work is to develop the method that will determine whether data from an EO sensor is sufficient to estimate two sets of target parameters or whether a single target is more applicable. The second goal is to quantify the effectiveness of this method theoretically and confirm these assertions via Monte Carlo (MC) simulations. Work has been done previously on extracting measurements of single targets, as well as two targets of possibly dissimilar intensity. The current work extends these works in providing a test to determine which method is best to employ. We consider point targets that deposit energy in the FPA according to a Gaussian point spread function (PSF) with parameter <sup>&sigma;</sup>PSF. The resolution determination method is framed as a hypothesis test, with the null hypothesis representing a single set of target parameters to be estimated and the alternate hypothesis indicating two sets of target parameters can be extracted. We derive the approximate type-I error and power of this test and present this data as a Receiver Operating Characteristic (ROC) for varying degrees of target separation. We also present the resolution probability versus target separation for varying target signal-to-noise ratio (SNR) differentials to compare this test with a commonly used approximation. Our simulated results show good agreement with theoretical derivations and we find that the test can nearly perfectly resolve these targets at separations above 0:8<sub>&sigma;PSF</sub> for SNR differentials up to 6dB.
Sentinel Lymph Node Biopsy for Breast Cancer: Impact of The Number of Sentinel Nodes Removed on The False-Negative Rate (2001)

The ability to identify multiple sentinel nodes, when they exist, improves the diagnostic accuracy of SLN biopsy. Injection of radioactive colloid in combination with blue dye improves the ability to identify multiple sentinel nodes compared with the use of blue dye alone.
The effect of liveweight and liveweight gain of ewes immediately post-weaning on the liveweight and survival of subsequent lambs (2012)

Thirteen-hundred and sixty-seven Romney mixed-aged ewes were randomly allocated to one of two liveweight gain treatments (high vs maintenance) from weaning of one litter of lambs until 71 days before the subsequent breeding (a period of 42 days). The aims of this study were first to determine whether ewe liveweight or liveweight gain treatment before rebreeding affected the number and liveweight of lambs produced and reared in the following season, and second, to identify whether the birth rank of the dam or the grand-dam affected the number, survival or liveweight of their lambs. Liveweight gain during the 42-day treatment period was greater (P &amp;lt; 0.05) in the high than maintenance treatment (87 ± 6 vs 4 ± 6 g/day, respectively), although it did not influence (P &amp;gt; 0.05) number of fetuses, lambs born or reared per ewe or total weight of lambs born or weaned per ewe. Ewe liveweight at weaning (113 days before rebreeding), and liveweight gain between the weaning and rebreeding, explained only a minor proportion of the variation in lamb liveweight at birth and weaning in the following season. Birth rank of the ewe or of the ewe’s dam did not (P &amp;gt; 0.05) influence liveweight or number of lambs born or weaned. In conclusion, this experiment indicated that liveweight and liveweight gain from weaning until rebreeding in the flock investigated had only a very minor influence on lamb production. Therefore, there appears to be little advantage in specifically managing ewes during this period to gain considerable amounts of liveweight.
Assembly of super-supertetrahedral metal–organic clusters into a hierarchical porous cubic framework (2012)

A porous framework comprising a super-supertetrahedral metal-organic cluster building block has been synthesized. Its cubic framework represents a multi-level hierarchical architecture and also possesses an interesting magnetic property.
Geospatial researchers assist local planners through participatory mapping surveys (2009)

The New River Valley Bicycle Association, Town of Blacksburg, and Virginia Tech's Center for Geospatial Information Technology are working together to provide a Web-based mapping survey, where cyclists are asked to document their routes and daily commutes.
One-pot catalytic conversion of biomass and alkanes: Kinetically coupling deoxygenation and dehydrogenation pathways (2018)

The stoichiometric hydrogen deficiency of carbohydrate feedstock implies that all conversion processes must remove oxygen and concurrently increase hydrogen content to form liquid hydrocarbon products. With support from the DOE Early Career program (DE-SC0008418) we have investigated the use of transition metal carbides for hydrodeoxygenation (HDO) chemistries using CH4 and H2 as co-reactants. We report that concurrently processing CH4 and C1-C3 oxygenates (oxygenate/CH4 = 0.01-0.1) at 950 K on molybdenum carbide clusters encapsulated in zeolite micropores results in a staged bed with upstream CH4 reforming and downstream CH4 dehydroaromatization. Forward rates of CH4 pyrolysis limited by CH4 activation are unperturbed by the introduction of oxygenates with a (C/H)eff <0.25 after rigorously accounting for the thermodynamic reversibility caused by the H2 produced in oxygenate reforming reactions and the fraction of the active catalyst bed deemed unavailable for CH4 dehydroaromatization. A binomial distribution of 12C/13C isotopologues of CO is observed upon introduction of CH313COOH/CH4 reactants suggesting that the introduction of oxygenates with a (C/H)eff <0.25 results in complete fragmentation of the oxygenate at these temperatures which in turn results in the invariance of forward rates of CH4 pyrolysis when using CO2, HCOOH, or CH3COOH co-feeds. The stoichiometric loss of oxygen as CO when co-processing C1-C3 oxygenates and CH4 at these temperatures demonstrates that (C/H)eff =(C-O)/H is a single valued descriptor for oxygen removal on Mo/HZSM-5 catalysts. Separately, we have demonstrated the utility of transition metal carbides for vapor phase catalytic hydrodeoxygenation using molecular hydrogen with high selectivity for C-O cleavage and near absence of sequential hydrogenation reactions at atmospheric hydrogen pressure and illustrated that the faculty of transition metal carbides for selective hydrodeoxygenation arises due to oxygen-modification of the catalyst in situ. The oxophilic characteristics of these materials engender both the observed acid-metal catalytic bifunctionality and selectivity for hydrodeoxygenation. The evolution of catalyst surface composition and catalytic function under oxidative reaction environments proffers unique challenges in structural characterization of these materials and in this context, we developed and demonstrated the use of chemical titration and chemical transient studies to assess catalytic site identity and densities.