gebhart/patrepeval huggingface dataset:
3DSNP: a database for linking human noncoding SNPs to their three-dimensional interacting genes (2016)

The vast noncoding portion of the human genome harbors a rich array of functional elements and disease-causing regulatory variants. Recent high-throughput chromosome conformation capture studies have outlined the principles of these elements interacting and regulating the expression of distal target genes through three-dimensional (3D) chromatin looping. Here we present 3DSNP, an integrated database for annotating human noncoding variants by exploring their roles in the distal interactions between genes and regulatory elements. 3DSNP integrates 3D chromatin interactions, local chromatin signatures in different cell types and linkage disequilibrium (LD) information from the 1000 Genomes Project. 3DSNP provides informative visualization tools to display the integrated local and 3D chromatin signatures and the genetic associations among variants. Data from different functional categories are integrated in a scoring system that quantitatively measures the functionality of SNPs to help select important variants from a large pool. 3DSNP is a valuable resource for the annotation of human noncoding genome sequence and investigating the impact of noncoding variants on clinical phenotypes. The 3DSNP database is available at http://biotech.bmi.ac.cn/3dsnp/.
Specific Feature of Copper Ion-Exchanged Mordenite for Dinitrogen Adsorption at Room Temperature (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSpecific Feature of Copper Ion-Exchanged Mordenite for Dinitrogen Adsorption at Room TemperatureYasushige Kuroda, Yuzo Yoshikawa, Shin-ichi Konno, Hideaki Hamano, Hironobu Maeda, Ryotaro Kumashiro, and Mahiko NagaoCite this: J. Phys. Chem. 1995, 99, 26, 10621–10628Publication Date (Print):June 1, 1995Publication History Published online1 May 2002Published inissue 1 June 1995https://pubs.acs.org/doi/10.1021/j100026a028https://doi.org/10.1021/j100026a028research-articleACS PublicationsRequest reuse permissionsArticle Views353Altmetric-Citations80LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Full-shell x-ray optics development at NASA Marshall Space Flight Center (2019)

NASA's Marshall Space Flight Center (MSFC) maintains an active research program toward the development of high-resolution, lightweight, grazing-incidence x-ray optics to serve the needs of future x-ray astronomy missions such as Lynx. MSFC development efforts include both direct fabrication (diamond turning and deterministic computer-controlled polishing) of mirror shells and replication of mirror shells (from figured, polished mandrels). Both techniques produce full-circumference monolithic (primary + secondary) shells that share the advantages of inherent stability, ease of assembly, and low production cost. However, to achieve high-angular resolution, MSFC is exploring significant technology advances needed to control sources of figure error including fabrication- and coating-induced stresses and mounting-induced distortions.
Total Synthesis of Zoanthamine Alkaloids, Part 2. Construction of the C1-C5, C6-C10, and C11-C24 Fragments of Zoanthamine. (1997)

This paper describes the construction of three key intermediates 11, 15 and 23 for a projected total synthesis of the marine alkaloid zoanthamine. These building blocks, corresponding to the C-1-C-5, C-6-C-10, and C-11-C-24 fragments of the target molecu
Optically multiplexed multi-gas detection using quantum cascade laser photoacoustic spectroscopy (2008)

We report high-throughput, nondispersive optical multiplexing of laser beams using a scanning galvanometer. We have utilized this technique for multispecies trace-gas detection using multiple quantum cascade laser photoacoustic spectroscopy. We demonstrate switching from one laser to another in less than 1 s, a performance level needed for a comprehensive multispecies sensor, and a high signal-to-noise ratio detection of five gaseous components, NH(3), NO(2), dimethyl methyl phosphonate (DMMP, a simulant for nerve agents), acetone, and ethylene glycol, in a room air gas mixture containing approximately 3 ppb of NH(3), approximately 8 ppb of NO(2), approximately 20 ppb of DMMP, approximately 30 ppb of acetone, and approximately 40 ppb of ethylene glycol.
Effect of Glucose and Amino Acids on Expression of K99 Antigen in Escherichia coli (1982)

K99 antigen production by enterotoxigenic Escherichia coli strains of bovine origin was investigated by slide agglutination and in vitro attachment to intestinal villi. Work with two strains (B41 and B44) showed that on minimal medium M2, K99 antigen was not repressed by a high concentration of glucose (2%, w/v). Growth on synthetic or complex medium did not affect K99 antigen detection, which was independent of capsular antigens, and its synthesis was not repressed by Casamino acids or glucose. A survey of 12 strains revealed two groups: in one group K99 antigen production was constitutive on basal medium without glucose, and in the second group K99 antigen was produced only in the presence of glucose. Immunoelectrophoresis patterns, and the results of slide agglutination and attachment tests, were dependent upon K99 type, whereas haemagglutination patterns were not.
Revisiting acquired aplastic anaemia: current concepts in diagnosis and management (2018)

Acquired aplastic anaemia is a rare, serious, immunologically mediated bone marrow failure syndrome, characterised by marrow hypoplasia of varying severity and significant pancytopenia. Careful attention and investigation, including molecular testing, is required to confirm the diagnosis and exclude other mimicking conditions, such as inherited bone marrow failure syndromes. In a proportion of patients, the disease evolves to myelodysplasia or acute myeloid leukaemia and in some there is an association with paroxysmal nocturnal haemoglobinuria. The disease has a major impact on patient quality of life. Haemopoietic stem/progenitor cell transplantation for eligible patients with an available donor is the only current curative therapy. Other patients may receive immunosuppression, most commonly with anti-thymocyte globulin and cyclosporin. An initial response to immunosuppression is often encouraging, but relapse is common. Supportive care, including management of transfusion requirements and infections, is central to management. Promising new diagnostic tools and emerging therapies will likely transform approaches to this important, chronic and life-threatening condition.
[Results of macular zone assessment with optical coherent tomography in patients with anterior endogenous uveitis]. (2011)

45 patients (50 eyes) with anterior endogenous uveitis of various ethiology were included into the study. Examination included traditional ophthalmologic evaluation, laboratory testing and Optical Coherent Tomography (Stratus OCT 3000 "Carl Zeiss Meditec"). Retinal foveola thickness was showed to be 194-350 microm in 38 eyes (76%) compared with control group (everage value 172+21 microm). The average central macular thickness in examined group was 222+26 microm, it is more than in control group by 50 microm (p < 0.05). These results allow us to suggest that the majority of patients with anterior eye inflammation have inflammatory changes in posterior segment.
Effect of Internal Crossflow Velocity on Film Cooling Effectiveness—Part I: Axial Shaped Holes (2017)

The effect of feeding shaped film cooling holes with an internal crossflow is not well understood. Previous studies have shown that internal crossflow reduces film cooling effectiveness from axial shaped holes, but little is known about the mechanisms governing this effect. It was recently shown that the crossflow-to-mainstream velocity ratio is important, but only a few of these crossflow velocity ratios have been studied. This effect is of concern because gas turbine blades typically feature internal passages that feed film cooling holes in this manner. In this study, film cooling effectiveness was measured for a single row of axial shaped cooling holes fed by an internal crossflow with crossflow-to-mainstream velocity ratio varying from 0.2 to 0.6 and jet-to-mainstream velocity ratios varying from 0.3 to 1.7. Experiments were conducted in a low speed flat plate facility at coolant-to-mainstream density ratios of 1.2 and 1.8. It was found that film cooling effectiveness was highly sensitive to crossflow velocity at higher injection rates while it was much less sensitive at lower injection rates. Analysis of the jet shape and lateral spreading found that certain jet characteristic parameters scale well with the crossflow-to-coolant jet velocity ratio, demonstrating that the crossflow effect is governed by how coolant enters the film cooling holes.
A fast 256×4 CMOS DRAM with a distributed sense and unique restore circuit (1987)

A 256 K/spl times/4 CMOS dynamic RAM has been fabricated using a double-poly single-metal n-well CMOS technology with a distributed sense and unique restore (DSR) circuit. The bit line is divided into two segment bit lines, and both n-channel and p-channel latches are connected to each segment bit line in the DSR structure, which provides an improved signal-to-noise ratio and saves the silicon area for decoders and an extra metal layer. The sensing scheme of the distributed sense and unique restore circuit is discussed. The novel bit-line precharge voltage (VPR) generator, which actually holds the VPR at V/SUB cc//2, is described.
An ultrasound-guided injection method for a syngeneic orthotopic murine model of breast cancer (2021)

Breast cancer is the most common cancer among women worldwide. For high-risk women, contrast enhanced (CE)-magnetic resonance imaging (MRI) is recommended as supplemental screening together with mammography. The development of new MRI contrast agents is an active field of research, which requires efficacy tests on appropriate preclinical pathological models. In this work, a refined method to orthotopically induce breast cancer in BALB/c mice was developed using ultrasound (US) as a guide for the precise localisation of the tumour induction site and to improve animal welfare. The method was coupled with CE-MRI to characterise the evolution of the tumoural lesion.
Localization of Oleuropeyl Glucose Esters and a Flavanone to Secretory Cavities of Myrtaceae (2012)

We report the widespread occurrence of structurally diverse oleuropeyl glucose esters, including the new diester eucaglobulin B, localized specifically to the essential oil secretory cavities of myrtaceous species. Clear taxonomic patterns in the composition of cavity extracts within the genus Eucalyptus are shown with species from subgenus Symphyomyrtus dominated by oleuropeyl glucose esters and species from subgenus Eucalyptus dominated instead by the flavanone, pinocembrin. We also examined the intra-species occurrence of oleuropeyl glucose esters by quantifying the abundant constituents cuniloside B and froggattiside A in trees from two populations of Eucalyptus polybractea R.T. Baker. All trees contained both compounds, which were positively correlated with total essential oil concentration. This apparent ubiquity of oleuropeyl glucose esters at both intra- and inter-specific levels in Eucalyptus is indicative of important physiological or ecological functions. The significance of their prevalence and the sequestration of these esters and also pinocembrin to the extracellular domain of secretory cavities is discussed in light of their potential biological activities and our findings that they are spatially segregated to the exterior of cavity lumina. The localization of oleuropeyl glucose esters to a specific and isolatable tissue type has the potential to aid in future elucidation of function and biosynthesis.
Plasma levels of the Lyso-Derivative of Platelet-Activating Factor in Acute Severe Systemic Illness (1989)

1. Evidence suggests that activation of phospholipase A2 and production of eicosanoids and platelet-activating factor (PAF) are involved in various responses associated with severe tissue damage and shock. It was postulated that the plasma level of the precursor and degradation product of PAF, lyso-platelet-activating factor (lyso-PAF), might be increased in acute severe illness. 2. After plasma extraction, lyso-PAF was acetylated in vitro to PAF, which was measured by bioassay using 5-[14C]hydroxytryptamine-labelled rabbit platelets. Measurements were made in 18 severely ill patients (five with cardiogenic shock; five with severe infection, five after repair of abdominal aortic aneurysm, two with acute pancreatitis; 13 males, five females). Plasma lyso-PAF in these patients was 33 +/- 15 (SD)ng/ml (range 5-111 ng/ml), whereas values in normal males (40-65 years) ranged from 102 to 253 ng/ml (n = 15) and in females from 74 to 174 ng/ml (n = 10). Depression of plasma lyso-PAF did not relate closely to the patient group nor to specific therapy, but repeated measurements in each of 10 patients showed an increase in plasma lyso-PAF (P less than 0.002), associated with clinical improvement. 3. Evidence was obtained indicating that neither the presence of an inhibitor in the assay system nor reconversion of PAF to lyso-PAF in vitro produced the unexpected depression of plasma lyso-PAF. 4. The mechanisms responsible, which may have therapeutic implications, remain to be elucidated.
17?-estradiol attenuates CREB decline in the rat hippocampus following seizure (1997)

Cyclic AMP response element-binding protein (CREB) is a transcription factor that has been implicated in the activation of a number of genes. We reported that CREB levels decline following a severe hypoglycemic episode in the hippocampus and cortex in the male rat brain. The present experiment was undertaken to investigate whether 17β-estradiol prevents the decline in CREB-immunoreactive cells following seizure in female rats. Rats were divided into four groups: ovariectomized (OVX), ovariectomized and insulin-treated (OVX-I), estrogen-replaced (E2), and estrogen-replaced and insulin-treated (E2-I). Generalized seizures were induced by injections with insulin (12.5 IU/kg, intraperitoneally) and animals were recovered by administration of glucose within 5 min of the occurrence of seizure. Control animals were injected with saline instead of insulin. All animals were perfused 90 min after recovery and the brains were processed for CREB immunoreactivity. CREB-positive neurons were counted using a computer-assisted program. Insulin treatment of OVX rats caused a significant decline in CREB-positive neurons in the CA1, CA3, and dentate gyrus compared to OVX rats. Estrogen treatment of OVX rats significantly increased CREB-positive neurons in the CA1 and dentate gyrus and attenuated the insulin-induced decline of CREB-positive neurons in all three regions compared to OVX rats. In conclusion, estrogens appear to induce CREB expression and attenuate its decline in the hippocampus following a severe hypoglycemic episode. © 1997 John Wiley & Sons, Inc. J Neurobiol 33: 961–967, 1997
Dielectric and Conduction Properties in Nickel Doped Barium Strontium Titanate Ceramics (1998)

Electrical properties of defect structure in Ni-doped (Ba 1- x Sr x )TiO 3 ceramics were studied by means of electron spin resonance (ESR), thermally stimulated current (TSC), dielectric and conduction measurements. A set of experimental results revealed that the nickel cations were located on the B-site of the perovskite in the form of Ni 2+ and mainly Ni 3+ leading to a slight increase of the diffusion characteristics of the para-ferroelectric transition and that the enhanced electric conduction observed at high temperatures is due to oxygen vacancy migration towards the cathode.
Metal electrode–free perovskite solar cells with transfer-laminated conducting polymer electrode (2015)

PSS top electrode is prepared from its aqueous solution through a transfer-lamination technique rather than direct spin-coating, which converts the CH(3)NH(3)PbI(3) into PbI(2). Perovskite solar cells with the structure of glass/FTO/c-TiO(2)/m-TiO(2)/CH(3)NH(3)PbI(3)/spiro-OMeTAD/PEDOT:PSS yield a maximum open-circuit voltage (V(OC)) of 1.02 V, and a maximum power conversion efficiency (PCE) of 11.29% under AM1.5 100 mW/cm(2) illumination. The whole device was fabricated in air without high-vacuum deposition which simplifies the processing and lowers the threshold of both scientific research and industrial production of perovskite solar cells.
Crystal Packing Arrangement, Chain Conformation, and Physicochemical Properties of Gemfibrozil Amine Salts (2017)

Salt formation is used to optimize pharmaceutical properties for carboxylic acid drugs, but selection can often be empirical. An extended series of salts of the anti-hyperlipidaemia carboxylic acid drug gemfibrozil was prepared using a related series of amine counterions to gain a molecular insight into the impact of crystal packing arrangements on their physicochemical properties. With only a few exceptions, the salts had similar crystal packing motifs. Although there was no discernible relationship between melting point of the salt form and the aqueous solubility of the salt across the whole data set, there were trends within structurally related series of salts relating increasing melting enthalpy with increasing molecular weight of the counterion.
Naturally occurring single amino acid replacements in a regulatory protein alter streptococcal gene expression and virulence in mice (2011)

Infection with different strains of the same species of bacteria often results in vastly different clinical outcomes. Despite extensive investigation, the genetic basis of microbial strain-specific virulence remains poorly understood. Recent whole-genome sequencing has revealed that SNPs are the most prevalent form of genetic diversity among different strains of the same species of bacteria. For invasive serotype M3 group A streptococci (GAS) strains, the gene encoding regulator of proteinase B (RopB) has the highest frequency of SNPs. Here, we have determined that ropB polymorphisms alter RopB function and modulate GAS host-pathogen interactions. Sequencing of ropB in 171 invasive serotype M3 GAS strains identified 19 distinct ropB alleles. Inactivation of the ropB gene in strains producing distinct RopB variants had dramatically divergent effects on GAS global gene expression. Additionally, generation of isoallelic GAS strains differing only by a single amino acid in RopB confirmed that variant proteins affected transcript levels of the gene encoding streptococcal proteinase B, a major RopB-regulated virulence factor. Comparison of parental, RopB-inactivated, and RopB isoallelic strains in mouse infection models demonstrated that ropB polymorphisms influence GAS virulence and disease manifestations. These data detail a paradigm in which unbiased, whole-genome sequence analysis of populations of clinical bacterial isolates creates new avenues of productive investigation into the pathogenesis of common human infections.
Distance field manipulation of surface models (1992)

A surface manipulation technique that uses distance fields-scalar fields derived geometrically from surface models-to combine, modify, and analyze surfaces is presented. It is intended for application to complex models arising in scientific visualization. Computing distance from single triangles is discussed, and an optimized algorithm for computing the distance field from an entire closed surface is built. The use of the fields for surface removal, interpolation and blending is examined. The strength of the approach is that it lets simple 3D algorithms substitute for potentially very complex 2D methods.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Corrections (2003)

We regret the misspelling of several author names in this article. The correct names of the authors are: Rainer Moog, MD, PhD, Thomas Zeiler, MD, Hans-Gert Heuft, MD, Bernhard Stephan, MD, Eike G. Fischer, PhD, Volker Kretschmer, MD, PhD, Regina Rödel-Spiecker, Erwin Strasser, MD, and Jürgen Zingsem, MD. July Cover We regret that the term of Thomas F. Zuck, MD, JD as Editor-in-Chief of TRANSFUSION was incorrectly stated. Dr. Zuck was the Editor of TRANSFUSION from 1981 until 1987. We sincerely apologize for this error. Strasser EF, Berger TG, Weisbach V, Zimmermann R, Ringwald J, Schuler-Thurner B, Zingsem J, Eckstein R. Comparison of two apheresis systems for the collection of CD14+ cells intended to be used in dendritic cell culture. Transfusion 2003; 43:1309-16. The names of the apheresis devices were confused on page 1310. The corrected text is shown below, with the apheresis devices in bold. A total of 50 leukapheresis procedures obtained by Spectra were enrolled in this study. We applied a modified MNC program using a reduced separation factor (SF) of 250 (Cobe Spectra: MNC version 5.1).11,12 The inlet blood flow was 50 mL per minute with a continuous collection rate (CR) of 1.0 mL per minute. The anticoagulant ACD-A (Fresenius) was set to an ACD-A to blood ratio of 1 in 10 as basic adjustment for all procedures that varied depending on citrate reactions. The SF of 250 was equivalent to a centrifugation speed of 646 rpm at this flow rate. The rate of the plasma pump was set manually by visual inspection of the cell interface visible in the separation chamber and the observation of the collection line to target a Hct of approximately 5 percent. A total of 30 leukapheresis procedures were performed with a modified MNC program of the Astec device (Fresenius NPBI) using a single-stage separation chamber (P1Y tubing set) and the software (Fresenius ASTEC 204: MNC, version 1.1.6.3).12 All procedures were conducted following the manufacturers’ recommendations.
Carbon‐13 nuclear magnetic resonance spectra of some mesoionic xanthine analogs (1983)

Abstract Natural abundance 13 C NMR chemical shifts have been experimentally determined for a series of mesoionic thiazolo[3,2‐ a ]pyrimidine‐5,7‐diones. The spectral data are compared with those of related mesoionic dihydrothiazolo[3,2‐ a ]pyrimidine‐5,7‐diones and mesoionic 1,3,4‐thiadiazolo[3,2‐ a ]pyrimidine‐5,7‐diones. Resonable correlation between the observed 13 C NMR chemical shifts and CNDO/2 total charge densities have been obtained for the different carbon atoms of 8‐methylthiazolo[3,2‐ a ]pyrimidine‐5,7‐dione.
A verification method for non-along track imaging based on three axis air bearing table (2018)

In this paper, a non-along track imaging mode for remote sensing of satellite is introduced, and a ground experiment verification method is proposed, the feasibility of the control scheme is verified by mathematical simulation and physical experiment. The control requirements of satellite attitude in the non-along track imaging process are analyzed, based on the quaternion feedback control method proposed by Bong Wie, the attitude maneuver control law satisfying various constraints is given. By constructing a small three axis air bearing table control system and camera imaging system, the non-along track imaging scheme is verified. The experimental results show that the pointing control accuracy is better than 0.05 ° , the tracking accuracy of attitude angular velocity is better than 0.005 ° /s, and the imaging result of non-along track is good.