gebhart/patrepeval huggingface dataset:
Potensi limbah kulit buah Nyirih Xylocarpus granatum sebagai inhibitor tirosinase (2014)

The aim of the present study was to analyse the peel waste of Xylocarpus granatum fruits as potential source of tyrosinase inhibitors. Dried peel samples were ground to yield a powder (simplicia). Subsequently, they were extracted with organic solvents of distinct polarity levels, namely n-hexane (non-polar), chloroform (semi-polar) and methanol (polar) by use of the single-maceration method. Inhibitory effects on tyrosinase activity (monophenolase) and DOPA auto-oxidation (diphenolase) were determined in bioassays. Assays with the methanol extract revealed IC50 values of 784.87 μg mL-1 (monophenolase) and of 1176.66 μg mL- 1 (diphenolase), respectively. In contrast, n-hexane and chloroform extracts showed no activity. These results indicate that the methanolic fruit peel extract contained tyrosinase-inhibiting compounds, such as flavonoids, tannins and saponins, whereas the nhexane and chloroform extracts yielded alkaloids, steroids and triterpenoids without tyrosinase-inhibiting activity. The phenolic compounds had a strong effect on the tyrosinase enzymes, inhibiting monophenolases by 97% and diphenolases by 96%, with a positive correlation between the total phenolic content and the inhibition rate in both activities. Penelitian ini bertujuan untuk menganalisis kulit buah Xylocarpus granatum sebagai sumber potensial inhibitor tirosinase. Sampel kering digiling untuk menghasilkan (serbuk) simplisia. Berikutnya, simplisia diekstraksi dengan pelarut organik dengan tingkat kepolaran yaitu n-heksana (non polar), kloroform (semi polar) dan metanol (polar) dengan menggunakan metode maserasi tunggal. Pengaruh inhibisi didalam aktivitas tirosinase (monofenolase) dan auto-oksidasi DOPA (difenolase) ditentukan di dalam uji. Uji ekstrak metanol menunjukkan masing-masing nilai IC50: 784,87 μg mL-1 (monofenolase) dan nilai IC50: 1176,66 μg mL- 1 (difenolase). Sebaliknya, ekstrak n-heksana dan kloroform menunjukkan tidak ada aktivitas. Hasil penelitian ini menunjukkan bahwa ekstrak metanol kulit buah X. granatum mengandung senyawa-senyawa yang menghambat aktivitas tirosinase seperti flavonoid, tanin dan saponin sedangkan ekstrak n-heksana dan kloroform menghasilkan senyawa alkaloid, steroid, dan triterpenoid tanpa penghambatan aktivitas tirosinase. Senyawa fenolik mempunyai pengaruh kuat dalam menginhibisi enzim tirosinase baik aktivitas monofenolase sebesar 97% dan aktivitas difenolase sebesar 96% dengan korelasi positif antara kandungan total fenol dan tingkat inhibisi pada kedua aktivitas
Parsumist: A Persian text summarizer (2009)

The rapid growth of online information services causes the problem of information explosion. Automatic text summarization techniques are essential for dealing with this problem. The process of compacting a source document to reduce complexity and length, retaining the most important information is called text summarization. This paper introduces PARSUMIST; a text summarization system for Persian documents. It can generate generic or topic/query-driven extract summaries for single or multiple Persian documents, using a combination of statistical, semantic and heuristic improved methods. In this paper we will first review the related works in this field and especially in Persian text summarization. Then we will present the architecture of PARSUMIST, its components and its features. The last section will evaluate the system and compare it to other existing ones.
Release of furosemide from sustained release microcapsules prepared by phase separation technique (1991)

Furosemide Eudragit RL-100 sustained release microcapsules were prepared using phase separation technique. The results of the release studies, in sorensen phosphate buffer at PH 7.4, indicated good sustained release of the prepared microcapsules. Increasing drug to polymer ratio resulted in a decrease in the release, while increased release obtained by increasing the PH of the dissolution medium. Dosing of healthy human volunteers with sustained release microcapsules resulted in a reduced and sustained urine volume compared to the profuse diuresis obtained with the conventional furosemide capsules.
RETRACTED: Titanium and titanium alloys in dentistry: Current trends, recent developments, and future prospects (2022)

Many implant materials have been used in various dental applications depending on their efficacy and availability. A dental implant must possess the required characteristics, such as biocompatibility, corrosion & wear resistance, adequate mechanical properties, osseointegration, etc., to ensure its safe and optimum use. This review analyzes various aspects of titanium (Ti) and Ti alloys, including properties, manufacturing processes, surface modifications, applications as dental implants, and limitations. In addition, it also presents a perception of recent advances in Ti-based implant materials and the futuristic development of innovative dental implants.
Supplementary Figure S2. Oncolytic adenovirus coding for trastuzumab shows superior cell killing efficacy when dosed according to functional titers from Oncolytic Adenovirus Expressing Monoclonal Antibody Trastuzumab for Treatment of HER2-Positive Cancer (2023)

&lt;p&gt;Breast cancer cell lines BT-474, SKBR3, JIMT-1, and MDA-MB-436 were infected with indicated viruses at increasing plaque-forming units per cell (pfu/cell). The pfu-titers were first determined for each virus in a standard tissue culture infectious dose 50 (TCID50) assay. Ad5/3-Î"24-tras mediated significantly higher cancer cell killing as compared to its oncolytic control virus Ad5/3-Î"24 (P&lt;0.001, P&lt;0.001, P&lt;0.05, and P&lt;0.01, in BT-474, SKBR3, JIMT-1, and MDA-MB-436 cells, respectively). Improved efficacy was especially apparent in HER2-positive trastuzumab sensitive BT-474 and SKBR3 cells, but interestingly, HER2-negative MDA-MB-436 cells were also more susceptible to trastuzumab-coding oncolytic adenovirus. Thus, despite the slower replication rate due to large genome size (Supplementary Fig. S1), the oncolytic potency of the engineered adenovirus was not impaired by the insertion of trastuzumab transgene. ***, P&lt;0.001; **, P&lt;0.01; *, P&lt;0.05; all Student's T tests.&lt;/p&gt;
Counterbalancing hydrodynamic sample distortion effects increases resolution of free‐flow zone electrophoresis (1998)

On fractionation of highly heterogeneous protein mixtures, optimal resolution was achieved by forcing proteins to migrate through a preestablished pH gradient, until they entered a medium with a pH similar but not equal to their pIs. For this purpose, up to seven different media were pumped through the electrophoresis chamber so that they were flowing adjacently to each other, forming a pH gradient declining stepwise from the cathode to the anode. This gradient had a sufficiently strong band-focusing effect to counterbalance sample distortion effects of the flowing medium as proteins approached their isoelectric medium closer than 0.5 pH units. Continuous free-flow zone electrophoresis (FFZE) with high throughput capability was applicable if proteins did not precipitate or aggregate in these media. If components of heterogeneous protein mixtures had already started to precipitate or aggregate, in a medium with a pH exceeding their pI by more than 0.5 pH units, the application of interval modus and media forming flat pH gradients appeared advantageous.
Synthesis and photoisomerization of optically active 2,2-dimethylphenylcyclopropane-1-d (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and photoisomerization of optically active 2,2-dimethylphenylcyclopropane-1-dPaul H. Mazzocchi and Robert S. LustigCite this: J. Am. Chem. Soc. 1975, 97, 13, 3714–3718Publication Date (Print):June 1, 1975Publication History Published online1 May 2002Published inissue 1 June 1975https://pubs.acs.org/doi/10.1021/ja00846a027https://doi.org/10.1021/ja00846a027research-articleACS PublicationsRequest reuse permissionsArticle Views52Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Structure of Sr-substituted photosystem II at 2.1 Å resolution and its implications in the mechanism of water oxidation (2013)

Oxygen-evolving complex of photosystem II (PSII) is a tetra-manganese calcium penta-oxygenic cluster (Mn4CaO5) catalyzing light-induced water oxidation through several intermediate states (S-states) by a mechanism that is not fully understood. To elucidate the roles of Ca(2+) in this cluster and the possible location of water substrates in this process, we crystallized Sr(2+)-substituted PSII from Thermosynechococcus vulcanus, analyzed its crystal structure at a resolution of 2.1 Å, and compared it with the 1.9 Å structure of native PSII. Our analysis showed that the position of Sr was moved toward the outside of the cubane structure of the Mn4CaO5-cluster relative to that of Ca(2+), resulting in a general elongation of the bond distances between Sr and its surrounding atoms compared with the corresponding distances in the Ca-containing cluster. In particular, we identified an apparent elongation in the bond distance between Sr and one of the two terminal water ligands of Ca(2+), W3, whereas that of the Sr-W4 distance was not much changed. This result may contribute to the decrease of oxygen evolution upon Sr(2+)-substitution, and suggests a weak binding and rather mobile nature of this particular water molecule (W3), which in turn implies the possible involvement of this water molecule as a substrate in the O-O bond formation. In addition, the PsbY subunit, which was absent in the 1.9 Å structure of native PSII, was found in the Sr-PSII structure.
PHYSICS OF THE 1 TERAFLOP RIKEN-BNL-COLUMBIA QCD PROJECT. (1998)

A workshop was held at the RIKEN-BNL Research Center on the afternoon of October 16, 1998, as part of the first anniversary ceremony for the center. Titled ''Workshop on Physics of the 1 Teraflop RIKEN-BNL-Columbia QCD Project'', this meeting brought together the physicists from RIKEN-BNL, BNL and Columbia who are using the QCDSP (Quantum Chromodynamics on Digital Signal Processors) computer at the RIKEN-BNL Research Center for studies of QCD. In addition, Akira Ukawa, a leader of the CP-PACS project at the University of Tsukuba in Japan, attended and gave a talk on the Aoki phase. There were also others in attendance who were interested in more general properties of the QCDSP computer. The QCDSP computer and lattice QCD had been presented during the morning ceremony by Shigemi Ohta of KEK and the RIKEN-BNL Research Center. This was followed by a tour of the QCDSP machine room and a formal unveiling of the computer to the attendees of the anniversary ceremony and the press. The rapid completion of construction of the QCDSP computer was made possible through many factors: (1) the existence of a complete design and working hardware at Columbia when the RIKEN-BNL center was being set up, (2) strong support for the project from RIKEN and the center and (3) aggressive involvement of members of the Computing and Communications Division at BNL. With this powerful new resource, the members of the RIKEN-BNL-Columbia, QCD project are looking forward to advances in our understanding of QCD.
Principled Graph Matching Algorithms for Integrating Multiple Data Sources (2015)

This paper explores combinatorial optimization for problems of max-weight graph matching on multi-partite graphs, which arise in integrating multiple data sources. In the most common two-source case, it is often desirable for the final matching to be one-to-one; the database and statistical record linkage communities accomplish this by weighted bipartite graph matching on similarity scores. Such matchings are intuitively appealing: they leverage a natural global property of many real-world entity stores-that of being nearly deduped-and are known to provide significant improvements to precision and recall. Unfortunately, unlike the bipartite case, exact max-weight matching on multi-partite graphs is known to be NP-hard. Our two-fold algorithmic contributions approximate multi-partite max-weight matching: our first algorithm borrows optimization techniques common to Bayesian probabilistic inference; our second is a greedy approximation algorithm. In addition to a theoretical guarantee on the latter, we present comparisons on a real-world entity resolution problem from Bing significantly larger than typically found in the literature, on publication data, and on a series of synthetic problems. Our results quantify significant improvements due to exploiting multiple sources, which are made possible by global one-to-one constraints linking otherwise independent matching sub-problems. We also discover that our algorithms are complementary: one being much more robust under noise, and the other being simple to implement and very fast to run.
Idiopathic Calcium Pyrophosphate Dihydrate (CPPD) Crystal Deposition Disease in a Young Male Patient: A Case Report (2003)

Calcium pyrophosphate dihydrate (CPPD) crystal deposition disease is a disease of the elderly and extremely rare in young individuals. If young people develop CPPD crystal deposition disease, it may be associated with metabolic diseases such as hemochromatosis, hyperparathyroidism, hypophosphatasia, hypomagnesemia, Wilson's disease, hypothyroidism, gout, acromegaly, and X-linked hypophosphatemic rickets. Therefore, in young-onset polyarticular CPPD crystal deposition disease, investigation for predisposing metabolic conditions is warranted. We report a case of a young male patient with idiopathic CPPD crystal deposition disease, who did not have any evidences of metabolic diseases after thorough evaluations. As far as we know, this is the first report of a young male patient presented with idiopathic CPPD crystal deposition disease.
Dynamics of DNA Polymers in Post Arrays:  Comparison of Single Molecule Experiments and Simulations (2007)

Understanding the dynamics of biopolymers in complex flows is critical for the successful design of lab-on-a-chip devices. In this paper, we demonstrate the first direct comparison of experiments and simulations of DNA transport in a pressure-driven post array flow. High aspect ratio ordered silicon posts arrays were microfabricated, and single molecule experiments were employed to examine the dynamics of DNA traversing through arrays of ordered obstacles. Three different geometries with varying post spacing were tested, and probability distributions of DNA hooking location and fractional DNA lengths were generated. It is demonstrated that the appropriate design of post array geometry can be used to control DNA conformation and guide the location of hooking events. Finally, agreement between experimental and Brownian dynamics simulation results is good, validating the simulations that can be used to guide future array designs.
Haemorrhagic gastroenteritis in the dog associated with Clostridium welchii (1978)

Two cases of peracute haemorrhagic enteritis in the dog are reported. Gram-positive bacilli, which were shown in one case to be Clostridium welchii were found adhering to the necrotic epithelial surfaces in parts of the gastrointestinal tract in both cases. Large numbers of C welchii were recovered from the intestines of both dogs.
Structural Characterization of Abscisic Acid and Related Metabolites by Chemical Ionization Mass Spectrometry (1984)

Conjugated metabolites of abscisic acid (ABA) have been characterized by their chemical ionization (CI) mass spectra using isobutane and ammonia as reagent gases. The CI mass spectra usually consist of quasimolecular ions ([QM]+), and constituent aglycone- and.sugar-derived ions. Hence, the spectra are simply interpreted and afford useful information for structutal characterization. CI examinations of ABA and its unconjugated metabolites and collisionally activated dissociation (CAD) measurements of selected ions were helpful in characterizing the constituent aglycones. The distinction between the two glycosidal forms, glycoside and glycosyl ester, has been also discussed in the corresponding conjugates. Confirmation of the fragmentation pathways via recognition of the diagnostic ions can be made by the extensive use of ammonia- d3 as an additional reagent gas.
A capacitive relative humidity sensor using polymer nanoparticles (2012)

This paper presents a relative humidity sensor that employs polyimide nanoparticles as the sensing medium. Nanoparticles are deposited through electrospraying process and exhibit higher linearity compared to a uniform film of polyimide that is deposited through a spin-on process. Another advantage of this sensor compared to the existing humidity sensors is its simple structure, which can decrease the fabrication costs. Experimental results were obtained to show different linearity of the humidity sensor under different parameters. Various sensor design parameters were studied in order to design a sensor with the best overall performance.
ChemInform Abstract: 4‐Benzylamino‐1‐chloro‐6‐Substituted Phthalazines: Synthesis and Inhibitory Activity Toward Phosphodiesterase 5. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Reactive uptake coefficients for N2O5 determined from aircraft measurements during the Second Texas Air Quality Study: Comparison to current model parameterizations (2009)

This paper presents determinations of reactive uptake coefficients for N 2 O 5 , γ (N 2 O 5 ), on aerosols from nighttime aircraft measurements of ozone, nitrogen oxides, and aerosol surface area on the NOAA P‐3 during Second Texas Air Quality Study (TexAQS II). Determinations based on both the steady state approximation for NO 3 and N 2 O 5 and a plume modeling approach yielded γ (N 2 O 5 ) substantially smaller than current parameterizations used for atmospheric modeling and generally in the range 0.5–6 × 10 −3 . Dependence of γ (N 2 O 5 ) on variables such as relative humidity and aerosol composition was not apparent in the determinations, although there was considerable scatter in the data. Determinations were also inconsistent with current parameterizations of the rate coefficient for homogenous hydrolysis of N 2 O 5 by water vapor, which may be as much as a factor of 10 too large. Nocturnal halogen activation via conversion of N 2 O 5 to ClNO 2 on chloride aerosol was not determinable from these data, although limits based on laboratory parameterizations and maximum nonrefractory aerosol chloride content showed that this chemistry could have been comparable to direct production of HNO 3 in some cases.
A Versatile Catalyst System for Suzuki−Miyaura Cross-Coupling Reactions of C(sp2)-Tosylates and Mesylates (2009)

A catalyst system for the Suzuki-Miyaura cross-coupling reactions of aryl and vinyl tosylates and mesylates has been developed. This catalyst displays excellent functional group tolerance and allows the coupling of heteroarylboronic acids with aryl tosylates and mesylates to be performed in high yields. Moreover, reactions employing alkylboronic acids, as well as heteroaryl, vinyl, and allylic pinacol boronate esters, were conducted with high efficiencies.
A Novel Scheme of Thermographic Microimaging Using Pyro‐Magneto‐Optical Indicator Films (2015)

A new method of imaging of temperature distributions is presented. The method is based on the use of a BiLu2 Fe4 GaO12 ferrimagnetic garnet layer as a pyro-magneto-optical detection layer. Thermal imaging with high sensitivity, with micrometer spatial and with millisecond temporal resolution is demonstrated in a contactless read-out scheme.
Ultraviolet and infrared spectroscopy of oh-/Cu+ double doped NaF (1995)

Abstract Electronic and vibrational absorption spectra of OH- and Cu+ double doped NaF are studied and compared with the same respective single impurity doped host material. New ultraviolet and infrared absorption bands are found, which are supposed to be from a coupling effect of Cu+—OH- defects. The infrared vibrational absorption of the OH- fundamental stretching mode, for uncoupled and coupled defects, were measured using a color center laser, with X cavity configuration and 0.2 cm-1 resolution. The observation of second harmonic absorption are analyzed and the ratio of overtone to fundamental reveals the existence of an electric anharmonicity in addition to the usual mechanical one observed in the Morse's potential model. Further measurements of thermally stimulated depolarization current indicate a permanent orientational freeze-in of the Cu+—OH- defect. Key Words: Key wordy optical absorptionOH-diatomic moleculeOH-/Cu+interactionNaF:OH-:Cu+.
Spinal Epidural Lipomatosis Causing Lumbar Canal Stenosis: A Pictorial Essay on Radiological Grading and the Role of Bariatric Surgery Versus Laminectomy (2022)

Spinal epidural lipomatosis (SEL) is a rare condition characterized by an excessive accumulation of adipose tissue in the spinal canal that can have a compressive effect on intraspinal neuroanatomical structures, leading to clinical symptoms. Several different conservative and surgical treatment strategies have been proposed but the treatment and outcomes remain controversial. There is a lack of severity-based evidence documenting the success of decompressive laminectomy in SEL and there are only anecdotal reports of clinico-radiological success with weight loss from bariatric surgery. This article demonstrates the resolution of SEL in two patients with bariatric surgery with the help of pre and postoperative MR imaging. The authors also highlight the classic "types" of spinal epidural lipomatosis with a surgically relevant grading system and elucidate the existence of concurrent extraspinal lipomatosis (i.e. mediastinal and intra-abdominal lipomatosis), drawing parallels with the natural history of SEL. The controversial question remains whether a symptomatic SEL patient needs a multilevel laminectomy for spinal decompression or bariatric surgery that can indirectly help the spinal condition. We propose that bariatric intervention could be better frontline management in patients with multifocal/multisystem lipomatosis (i.e., combined spinal and extraspinal) and spinal decompression would be ideal for those SEL patients with coexisting bony and/or ligamentous spinal canal or foraminal stenosis. This manuscript serves as a comprehensive and contemporary update on the radiological profile and two plausible treatment paths and will look toward further verification by a randomized clinical trial.