gebhart/patrepeval huggingface dataset:
Data from Expression of Carcinoembryonic Antigen Cell Adhesion Molecule 6 Oncoprotein in Atypical Ductal Hyperplastic Tissues Is Associated with the Development of Invasive Breast Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Background:&lt;/b&gt; Epidemiologic studies have established that women with prior atypical ductal hyperplastic (ADH) lesions have a 5-fold increased risk of developing invasive breast cancer (IBC). However, there is currently no means of identifying a subclass of ADH from women who will most likely develop cancer. The purpose of this study is to investigate whether elevated expression of carcinoembryonic antigen cell adhesion molecule 6 (CEACAM6) in ADH tissues is associated with the development of IBC.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Methods:&lt;/b&gt; A retrospective study was conducted with archival ADH tissues and clinical information on the development/nondevelopment of IBC. The control group was ADH from patients who had no prior history of IBC and did not develop cancer within 5 years after the diagnosis of ADH (&lt;i&gt;n&lt;/i&gt; = 44). The test group was ADH from patients who either developed cancer concurrently or subsequently after diagnosis (ADHC; &lt;i&gt;n&lt;/i&gt; = 44). The expression of CEACAM6 was studied by immunohistochemistry and the results were statistically analyzed for significant association to develop cancer (&lt;i&gt;P&lt;/i&gt; value), specificity, sensitivity, positive predictive value, and negative predictive value.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Of the 44 control ADH tissues from patients with no history of cancer, 9 were positive for CEACAM6. Among the ADHC tissues, 40 of 44 samples were positive. Statistical analysis of CEACAM6 expression data showed a significant association between its expression and cancer development, high sensitivity, specificity, positive predictive value, and negative predictive value.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; The expression of CEACAM6 in ADH lesions is strongly associated with the development of IBC, therefore, it can be applied as a diagnostic marker either singly or in combination with other marker(s) to predict IBC development in women with ADH lesions. It could also be a potential molecular therapeutic target for preventing IBC.&lt;/p&gt;&lt;/div&gt;
Incompatibility of Latamoxef Sodium Injection (1983)

In order to examine changes in sodium latamoxef (6059-S; LMOX) due to compounding, it was mixed in solution with each of 26 different commercial replacement fluids and 70 different injections. In addition, changes in the mixed injections containing replacement fluids actually used in wards were examined for stability. Decomposition products were investigated by thin-layer chromatography and bioautography, and the residual potency was determined by the microbiological assay (cylinder-plate method).Aqueous solutions of LMOX were stable in the replacement fluid for 24 hours; however, there were apparent changes in mixed injections containing no replacement fluids, such as Atarax-p, Bisolvon, Cepharanthin, FOY and Horizon. In Neophyllin, the solution showed a decrease in potency with the lapse of time, but was stable in prescriptions of drugs with a replacement fluid, time of 6 hours causing no change in appearance, pH, or potency.
Pathogenic FBN1 variants in familial thoracic aortic aneurysms and dissections (2015)

Marfan syndrome (MFS) due to mutations in FBN1 is a known cause of thoracic aortic aneurysms and acute aortic dissections (TAAD) associated with pleiotropic manifestations. Genetic predisposition to TAAD can also be inherited in families in the absence of syndromic features, termed familial TAAD (FTAAD), and several causative genes have been identified to date. FBN1 mutations can also be identified in FTAAD families, but the frequency of these mutations has not been established. We performed exome sequencing of 183 FTAAD families and identified pathogenic FBN1 variants in five (2.7%) of these families. We also identified eight additional FBN1 rare variants that could not be unequivocally classified as disease-causing in six families. FBN1 sequencing should be considered in individuals with FTAAD even without significant systemic features of MFS.
Reservoir Geomechanical Modeling during CO 2 Injection into Deep Qasim Reservoir: A Study Focused on Mitigating Climate Change (2020)

The storage of CO2 in sedimentary reservoirs is one of the possible ways to alleviate the global warming caused due to the extensive emission of greenhouse gases. The concentration of CO2 in the environment is continuously increasing and if the excess amount of CO2 is not captured and stored, the concentration is expected to increase exponentially in the future. The excess CO2 in the atmosphere need to be stored in deep sedimentary reservoirs. Once CO2 is injected into the reservoir, it is mandatory to track the various associated issues like the migration of CO2 towards the caprock, the pressure buildup, ground uplift, and faults reactivation during CO2 injection. All of these issues need to be monitored to avoid the leakage of CO2 from the reservoir. In this paper, a numerical modeling study is performed to model the geomechanical behavior of the deep Qasim Reservoir in Saudi Arabia. The pore pressure buildup and ground uplift was calculated during CO2 injection into the reservoir. The reservoir stability analysis was performed using Mohr-Coulomb failure criterion.
Effect of Alcalase™ on olive pomace protein extraction (2000)

Abstract The effect of Alcalase ™ treatment on olive pomace protein extraction has been studied. Alcalase improves protein extraction from 5 to 30% of total protein. This improvement is not accompained by an increase in degree of protein hydrolysis, probably because protease activity is inhibited by secondary metabolites and the substrate is highly denatured and resistant to hydrolysis. The increase in protein extraction is attributed to fiber solubilization as a result of secondary activities of Alcalase. Protein extracts with a high content of soluble fiber have improved functional properties, with respect to olive pomace, such as water and oil absorption. Emulsifying and foaming activities were inappreciable. The products obtained represent a suitable source of soluble fiber and protein and may contribute to the improvement of the economic status of olive pomace by‐product.
Secondary Malignant Fibrous Histiocytoma Following Refractory Langerhans Cell Histiocytosis (2009)

We describe a rare case of secondary malignant fibrous histiocytoma (MFH) following Langerhans cell histiocytosis (LCH). A 23-year-old Japanese male exhibited systemic lymphadenopathy, multiple lung tumors, and osteolytic changes in bilateral iliac bones in 1989. A biopsy specimen from the left iliac bone revealed an infiltration of S-100 protein-positive histiocyte-like cells intermingled with eosinophils, which confirmed the diagnosis of eosinophilic granuloma, a type of LCH. Although the patient was treated with prednisolone initially, the disease did not respond well and progressed gradually over time. The patient subsequently received multiple courses of chemotherapy and immunosuppressive therapy with many kinds of anticancer agents for 6 years. He also received radiotherapy totaling 136.8 Gy for lung tumors and osteolytic lesions of the pelvis. In 1997, because of the LCH refractoriness, biopsy was performed again from the right inguinal lymph node. Microscopic examinations demonstrated a mixture of spindle-shaped cells and histiocyte-like cells, which appeared to be in a storiform pattern. The tumor cells were immunohistologically positive for CD68 and vimentin, but negative for CD1a and S-100 protein. Therefore, the patient was diagnosed with MFH. Although chemotherapy was continued, the patient died of pneumonia during the neutropenic period following chemotherapy. Autopsy revealed systemic invasion of MFH and dissemination of mucormycosis. LCH was not detected histologically in any tissues.
Polytypism in semi-disordered lizardite and amesite by low-dose HAADF- STEM (2020)

Earth and Space Science Open Archive This preprint has been submitted to and is under consideration at American Mineralogist. ESSOAr is a venue for early communication or feedback before peer review. Data may be preliminary.Learn more about preprints preprintOpen AccessYou are viewing the latest version by default [v1]Polytypism in semi-disordered lizardite and amesite by low-dose HAADF- STEMAuthorsHuiZhangiDPiotrZarzyckiBenjaminGilbertJillian FBanfieldSee all authors Hui ZhangiD• Submitting AuthorLawrence Berkeley National LaboratoryiDhttps://orcid.org/0000-0003-2269-320Xview email addressThe email was not providedcopy email addressPiotr ZarzyckiLawrence Berkeley National Laboratoryview email addressThe email was not providedcopy email addressBenjamin GilbertLawrence Berkeley National Laboratoryview email addressThe email was not providedcopy email addressJillian F BanfieldCorresponding AuthorLawrence Berkeley National LaboratoryUniversity of Californiaview email addressThe email was not providedcopy email address
Purification and characterization of the flavoenzyme glutathione reductase from rat liver. (1975)

Glutathione reductase from rat liver has been purified greater than 5000-fold in a yield of 20%. The molecular weights of the enzyme and its subunits were estimated to be 125,000 and 60,000, respectively, indicating that the native enzyme is a dimer. The enzyme molecular contains 2 FAD molecules, which are reducible by NADPH, GSH or dithioerythritol. The reduced flavin is instantaneously reoxidized by addition of GSSG. The steady state kinetic data are consistent with a branching reaction mechanism previously proposed for glutathione reductase from yeast (MANNERVIK, B. (1973) Biochem. Biophy. Res. Commun. 53, 1151-1158). This mechanism is also favored by the nonlinear inhibition pattern produced by NADP-+. However, at low GSSG concentrations the rate equation can be approximated by that of a simple ping pong mechanism. NADPH and the mixed disulfide of coenzyme A and GSH were about 10% as active as NADPH and GSSG, respectively, whereas some sulfenyl derivatives related to GSSG were less active as substrates. The pH activity profiles of these substrates differed from that of the NADPH-GSSG substrate pair.
Efficient service management systems in future open competitive communication systems (2002)

Efficient management will be a key factor for the future open competitive communications systems. The separation of service providers and connectivity providers requires the optimum usage of network resources. This separation of roles allows service providers to offer services with different QoS and to charge their services according to the QoS they require. In this presentation a solution for the resource reservation depending on users' requests is given.
Modeling water flux in forward osmosis: Implications for improved membrane design (2007)

Abstract Osmotically‐driven membrane processes, such as forward osmosis and pressure retarded osmosis, operate on the principle of osmotic transport of water across a semipermeable membrane from a dilute feed solution into a concentrated draw solution. The major hindrance to permeate water flux performance is the prevalence of concentration polarization on both sides of the membrane. This article evaluates the external and internal boundary layers, which decrease the effective osmotic driving force. By modeling permeate flux performance, the role that feed and draw concentrations, membrane orientation, and membrane structural properties play in overall permeate flux performance are elucidated and linked to prevalence of external and internal concentration polarization. External concentration polarization is found to play a significant role in the reduction of driving force, though internal concentration polarization has a far more pronounced effect for the chosen system conditions. Reduction of internal concentration polarization by way of membrane modification was found to improve the predicted flux performance significantly, suggesting that alteration of membrane design will lead to improved performance of osmotically driven membrane processes. © 2007 American Institute of Chemical Engineers AIChE J, 2007
Examining Common and Specialized Soccer Content Knowledge and Demographic Variables of Chinese Physical Education Teachers (2021)

Purpose : To examine the relationships among demographic variables, common content knowledge (CCK), and specialized content knowledge (SCK) of Chinese physical education teachers in teaching soccer. Methods : One hundred twenty-nine physical education teachers’ CCK was assessed using 27 multiple choice questions, and SCK was assessed using content maps using an SCK index score. The data were analyzed using descriptive statistics, and multiple regression analyses were conducted to determine the relationships to demographic variables as predictors of CCK and SCK. A Spearman test assessed the associations between variables. Results : For CCK, 88.4% of the teachers scored at or above 60% correct in the test. The teacher’s gender (β = 0.22, t = −2.53, p &lt; .05) and the number of soccer workshops attended (β = 0.33, t = 2.96, p &lt; .001) significantly predicted CCK. About 92.2% of the teachers had an SCK index score of &lt;2.9. The number of soccer workshops attended (β = 0.31, t = 2.74, p &lt; .05) and teaching rank significantly predicted the SCK score. There was no relationship found between CCK and SCK. Conclusions : For these participants, their preservice education and their professional development did not serve them well in teaching CCK and SCK.
Stimulation of liver growth by exogenous human hepatocyte growth factor in normal and partially hepatectomized rats (1993)

Human hepatocyte growth factor stimulates DNA synthesis by cultured rat hepatocytes. When human hepatocyte growth factor prepared from the culture medium of human embryonic lung fibroblasts was intravenously injected into normal rats and rats after 70% hepatectomy, it was detected in hepatocytes but not in nonparenchymal cells isolated 30 min after injection. Similar injections of human hepatocyte growth factor at 2-hr intervals for 10 hr significantly increased hepatic DNA content in normal rats at 48 hr, with increased hepatic content of putrescine, the essential polyamine for hepatic DNA synthesis after 70% hepatectomy, and activities of catalytic enzymes of putrescine synthesis at 6 hr almost to the levels in rats after 70% hepatectomy. Those levels in rats after 70% hepatectomy were further enhanced by similar injections of human hepatocyte growth factor starting immediately after surgery. Increased hepatic DNA content in normal rats and rats after 70% hepatectomy was also seen with recombinant human hepatocyte growth factor to a greater extent compared with that seen with human hepatocyte growth factor. In normal rats given recombinant human hepatocyte growth factor, 5-bromo-2'-deoxyuridine-labeled and mitotic hepatocytes were significantly increased in number at 26 hr but not at 48 hr. We conclude that exogenous human hepatocyte growth factor acts as a trigger and a promoter of liver growth to increase hepatic putrescine production in rats. Recombinant human hepatocyte growth factor is more potent than human hepatocyte growth factor in this action.
The avian retrovirus env gene family: molecular analysis of host range and antigenic variants. (2020)

The nucleotide sequence of the env gp85-coding domain from two avian sarcoma and leukosis retrovirus isolates was determined to identify host range and antigenic determinants. The predicted amino acid sequence of gp85 from a subgroup D virus isolate of the Schmidt-Ruppin strain of Rous sarcoma virus was compared with the previously reported sequences of subgroup A, B, C, and E avian sarcoma and leukosis retroviruses. Subgroup D viruses are closely related to the subgroup B viruses but have an extended host range that includes the ability to penetrate certain mammalian cells. There are 27 amino acid differences shared between the subgroup D sequence and three subgroup B sequences. At 16 of these sites, the subgroup D sequence is identical to the sequence of one or more of the other subgroup viruses (A, C, and E). The remaining 11 sites are specific to subgroup D and show some clustering in the two large variable regions that are thought to be major determinants of host range. Biological analysis of recombinant viruses containing a dominant selectable marker confirmed the role of the gp85-coding domain in determining the host range of the subgroup D virus in the infection of mammalian cells. We also compared the sequence of the gp85-coding domain from two subgroup A viruses, Rous-associated virus type 1 and a subgroup A virus of the Schmidt-Ruppin strain of Rous sarcoma virus. The comparison revealed 24 nonconservative amino acid changes, of which 6 result in changes in potential glycosylation sites. The positions of 10 amino acid differences are coincident with the positions of 10 differences found between two subgroup B virus env gene sequences. These 10 sites identify seven domains in the sequence which may constitute determinants of type-specific antigenicity. Using a molecular recombinant, we demonstrated that type-specific neutralization of two subgroup A viruses was associated with the gp85-coding domain of the virus.
Cold Atmospheric Plasma Exerts Antimicrobial Effects in a 3D Skin Model of Cutaneous Candidiasis (2023)

Cutaneous candidiasis is characterized by an overgrowth of <i>Candida</i> leading to skin inflammation and infection. Similar to bacteria, <i>Candida</i> can develop tolerance to common antifungal drugs. Cold atmospheric plasma (CAP), with its proven antimicrobial properties, offers a promising alternative to the prevailing methods. Because of plasma heterogeneity each new device must be tested individually for its effectiveness. Antimicrobial activity is usually studied using planktonic microorganisms or animal models, making it difficult to extrapolate the results to the human system. Therefore, a 3D skin model of cutaneous candidiasis for the antimicrobial testing of CAP was established. First, the reaction of the 3D-skin model to <i>Candida</i> infection was examined using various histological and molecular-biological methods. Infection with <i>C. albicans</i> resulted in increased expression and secretion of pro-inflammatory cytokines and augmented expression of antimicrobial peptides. Within 48 h, hyphal growth spread throughout the model and caused tissue damage. Second, the CAP treatment was employed. It was shown that CAP significantly reduced the spread of the yeast in the infected skin models as well as decreased the expression and secretion of the infection markers. The plasma device exhibited a high antifungal activity by completely inhibiting hyphal growth and reducing inflammation at the highest treatment duration.
Evaluating Risk at Road Intersections by Detecting Conflicting Intentions (2012)

This paper proposes a novel approach to risk assessment at road intersections. Unlike most approaches in the literature, it does not rely on trajectory prediction. Instead, dangerous situations are identified by comparing what drivers intend to do with what they are expected to do. Driver intentions and expectations are estimated from the joint motion of the vehicles, taking into account the layout of the intersection and the traffic rules at the intersection. The proposed approach was evaluated in simulation with two vehicles involved in typical collision scenarios. An analysis of the collision prediction horizon allows to characterize the efficiency of the approach in different situations, as well as the potential of different strategies to avoid an accident after a dangerous situation is detected.
Trials directly comparing alternative spontaneous breathing trial techniques: a systematic review and meta-analysis (2017)

Patients undergoing PS (vs T-piece) SBTs appear to be 6% (95% CI 2-10%) more likely to be extubated successfully and, if the results of an outlier trial are excluded, 6% (95% CI 1-12%) more likely to pass an SBT. Future trials should investigate patients for whom SBT and extubation outcomes are uncertain and compare techniques that maximize differences in support.
A Multimodal Approach for the Safeguarding and Transmission of Intangible Cultural Heritage: The Case of i-Treasures (2018)

Intangible Cultural Heritage (ICH) creations include, amongst other, music, dance, singing, theatre, human skills, and craftsmanship. These cultural expressions are usually transmitted orally and/or using gestures and are modified over a period of time, through a process of collective recreation. As the world becomes more interconnected and many different cultures come into contact, local communities run the risk of losing important elements of their ICH, while young people find it difficult to maintain the connection with the cultural heritage treasured by their elders. In this paper, we present a novel holistic approach for the safeguarding and transmission of ICH that goes beyond the mere digitization of ICH content. Based on multisensory technology for the capturing of ICH, the proposed approach enables the generation of completely novel cultural content. High-level semantics are extracted from the acquired data, enabling researchers to identify possible implicit or hidden correlations between different ICH expressions or interpretation styles and study the evolution of a specific ICH. These data, coupled with other cultural resources, are accessible through the i-Treasures Web-platform, which provides the means for supporting knowledge exchange between researchers as well as know-how transmission from ICH bearers to apprentices.
Electrical sliding joint literature review (viewgraph presentation) (1985)

This survey covered the following sliding joint options: (1) multilam joints, (2) finger joints, (3) wire brushes, (4) composite copper/graphite brushes, and (5) joint performance at low temperatures. (MOW)
Rapid Detection of Highly Pathogenic Avian Influenza H5N1 Virus by TaqMan Reverse Transcriptase–Polymerase Chain Reaction (2007)

Highly pathogenic avian influenza (AI) H5N1 viruses have been spreading from Asia since late 2003. Early detection and classification are paramount for control of the disease because these viruses are lethal to birds and have caused fatalities in humans. Here, we described TaqMan reverse transcriptase-polymerase chain reaction assays for rapid detection of all AI viruses (influenza type A) and for identification of H5N1 of the Eurasian lineage. The assays were sensitive and quantitative over a 10(5)-10(6) linear range, detected all of the tested AI viruses, and enabled differentiation between H5 and H7 subtypes. These tests allow definitive confirmation of an AI virus as H5 within hours, which is crucial for rapid implementation of control measures in the event of an outbreak.
Network attack visualization and response through intelligent icons (2009)

Determination of appropriate response to information system attack is jointly determined by confidence of classification, nature (type) of attack, and confidence in effectiveness of response. In this paper we present a technique to rapidly assess similarity of observed behavior to attack or normal models: displaying the similarity of observed data to learned Minimum Description Length Models for normal and attack behaviors using “intelligent icons”. These icons provide a visual indication of similarity to normal and attack signatures and can alert human operators to the key motifs and signatures that affect confidence in classification and indicated response.