gebhart/patrepeval huggingface dataset:
Can Inhibition of Soluble Epoxide Hydrolase Ameliorate Increased Susceptibility to DSS Induced Colitis in Soybean Oil Fed Mice? (2018)

The incidence of inflammatory bowel disease (IBD) in the U.S. has increased significantly since 1980, preceded by a remarkable increase in the prevalence of soybean oil (SO) in the American diet. Although the role of SO in the etiology of IBD is ambiguous, one of its major components, linoleic acid (LA), is associated with an increased risk of ulcerative colitis (UC). LA is metabolized into oxylipins (also referred to as leukotoxins) via a two‐step reaction involving cytochrome P450 enzymes and the enzyme soluble epoxide hydrolase (sEH). We have recently shown that a diet high in SO (and thus LA) increases the accumulation of oxylipins generated by the cytochrome P450 (CYP)/soluble epoxide hydrolase (sEH) pathway in the liver (PMID: 28970503). Our lab has previously shown that LA decreases the protein levels of the transcription factor hepatocyte nuclear factor 4 alpha (HNF4α) in wild type mouse livers (PMID: 19440305) and that a proper balance of HNF4α isoforms is required for the development and proper functioning of the gut (PMID: 27166517). To investigate the effect of dietary soybean oil on intestinal health, mice were fed either a low‐fat, high fiber vivarium chow diet (Viv) or a high soybean oil plus fiber diet (SO+f) with 19 kcal% LA and the same amount of fiber as Viv. Both male and female C57BL/6N (WT) mice and HNF4α exon‐swap mice (genetically engineered to express just the P1‐form of HNF4α so that in tissues, such as intestine, where both P1 and P2 promoters are active, only HNF4α1/2 is expressed instead of both HNF4α1/2 and HNF4α7/8 (PMID: 16498401)) were put on the diets at weaning. Colitis was induced by Dextran Sodium Sulfate (DSS) treatment eight to nine weeks after weaning. Increased weight loss was observed in both male and female HNF4α (A1HMZ) transgenic mice compared to WT mice, regardless of diet. Differences in other parameters, such as spleen weight, colonic and small intestinal length, that could be attributed to differences in diet and/or HNF4α isoform were also observed. Experiments with an inhibitor of soluble epoxide hydrolase are underway to determine whether soybean oil affects the balance between the HNF4α isoforms via LA diols and whether blocking the production of these oxylipins will make the mice more resistant to DSS induced colitis. Support or Funding Information Supported by CCFA CDA 454808 (P.D.), USDA NIFA Hatch project CA‐R‐NEU‐5680 (F.M.S.), NIEHS grant R01‐ES002710 (B.D.H.), Superfund Research Program P42 ES04699 (B.D.H.). This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .
Person-to-Person Transmission of Andes Virus in Hantavirus Pulmonary Syndrome, Argentina, 2014 (2020)

Andes virus is unique among hantaviruses because it can be transmitted from person to person. This mechanism was previously supported by epidemiologic data and genetic evidence based only on partial sequences. We used full-length virus sequencing to confirm person-to-person transmission of this virus in a cluster of 3 cases in Argentina in 2014.
High density lipoprotein-3 heterogeneity in subjects with the apo-AIMilano variant. (1982)

The structure of high density lipoproteins (HDL) isolated from subjects with the AIMilano (AIM) apoprotein variant was studied by the use of the cross-linking reagent dimethylsuberimidate. The HDL2 subfraction is markedly reduced, as compared to control subjects; the HDL3 subfraction, on the other hand, shows a marked heterogeneity, being characterized by at least three particle subpopulations, identified as HDL3-I, HDL3-II, and HDL3-III. The HDL3 fraction purified from the AI Milano subjects eluted as a symmetrical peak from a 6% agarose column, corresponding to a unimodal particle size distribution. The content of the different HDL3 particles, detected by cross-linking, varied widely along the elution profile, the tail of the peak being enriched in anomalous particles of very small size (HDL3-III). Apoprotein compositional studies indicated that these small HDL3-III may be enriched in the AIM monomer, the larger particles containing more AIM-AII complexes and AIM dimers. All the anomalous HDL3 particles are triglyceride enriched, with a decreased cholesterol ester content. They may be an intermediate product in the cholesterol transfer chain between HDL and very low density lipoproteins, or be generated during interconversion of HDL. These particles may have a functional role in tissue cholesterol homeostasis; their unusual compositional changes may help explain the protection of the studied subjects from tissue cholesterol deposition, in spite of the marked decrease of the total HDL fraction.
Document Summarization and Information Extraction for Generation of Presentation Slides (2009)

In this paper, a semi automated technique to generate slide presentations from english text documents is proposed. The technique discussed in this paper is considered to be a pioneering attempt in the field of NLP (Natural Language Processing). The technique involves an information extractor and a slide generator, which combines certain NLP methods such as segmentation, chunking, summarization etc.., with certain special linguistic features of the text such as the ontology of the words, noun phrases found, semantic links, sentence centrality etc., In order to aid the language processing task, two tools can be utilized namely, <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">MontyLingua</i> which helps in chunking and <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Doddle</i> helps in creating an ontology for the input text represented as an OWL (Ontology Web Language) file. The process of the technique comprises of extracting text, creating an ontology, identifying important phrases for bullets and generating slides.
Buttressing effect in carbene chemistry. Effect of 3-alkyl groups on the reactions of 2-alkoxydiphenylcarbenes (1991)

Irradiation of 2-methoxydiphenyldiazomethane 1a in diethyl ether at 10 °C gave 3-phenyldihydrobenzofuran 3a along with a small amount of the ether adduct 4a, which became the major product when the irradiation was carried out in the ether matrix at –196 °C. The reaction patterns were dramatically changed as an alkyl group was introduced into the 3-position of substrates 1. Thus, irradiation of 2-methoxy-3-alkyldiphenyldiazomethanes 1b–d in diethyl ether either at 10 °C or at –196 °C afforded the corresponding benzofurans 3b–d at the complete expense of the ether adducts 4b–d. The results are nicely explained in terms of the buttressing effect of the 3-alkyl group, which prevents the 2-methoxy group from lying in the plane of the phenyl ring in the precursor molecules and assists the methoxy group in rotating around the C–O bond toward the carbene centre after elimination of N2. Generation of carbenes 2 in methanol at 10 °C produced O–H-insertion adducts 5 as the major product at the expense of benzofurans 3. The ether 5a was formed as a major product in the reaction of carbene 2a with the alcohol matrix at –196 °C, but the benzofurans 3 became the major product in the irradiation of substrates 1b–d in methanol matrix at –196 °C. The results are again explicable in terms of the buttressing effect of 3-alkyl substituents on the relative populations of the rotational isomers of the carbenes 2.The effect of the 3-alkyl group on the reaction of 2,2′,5′-trimethoxydiphenylcarbenes 7 which form two kinds of intramolecular C–H-insertion products 8 and 9 were studied and the results are again discussed in terms of the buttressing effect.
ChemInform Abstract: Synthesis and Structure‐Optical Rotation Relationships of Homochiral, Monodisperse, Tartaric Acid‐Based Dendrimers. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: RK. VON FUCUSTERIN‐24,28‐EPOXID MIT BORTRIFLUORID‐AETHERAT (1972)

Abstract ′lnl Die Umsetzung der Epoxide (Ia) und (Ib) mit Bortrifluorid‐ätherat in Benzol bei Raumtemperatur liefert nach 10 Sek. die Verbindungen (IIa) und (IIb) sowie (IIIa) und (IIIb).
Distance based neighbor correlation for the segmentation (2013)

This paper introduces the segmentation of point cloud with the distance-based connectivity that is originated from the connectivity of local convexity criterion to enhance its accuracy and singularity [1]. The proposed feature is applied to calculate the weighted normal vector and to partition ground and objects respectively through integrating it with other features. The performances of segmentations with the introduced criterion are demonstrated with the labeled simulation data and the real data from 3D LIDAR compared to the original connectivity.
In-vitro responses of T lymphocytes to poly(butylene succinate) based biomaterials (2017)

PBSu and PBSu/TCP composites were non-toxic to T lymphocytes and did not induce unfavorable responses of T lymphocytes. The tested biomaterials down-regulated key proinflammatory cytokine genes and up-regulated anti-inflammatory cytokine genes in T lymphocytes. These suggest that the biomaterials studied are good candidates as bone graft materials.
CuS-Decorated GaN Nanowires on Silicon Photocathodes for Converting CO2 Mixture Gas to HCOOH (2021)

Hybrid materials consisting of semiconductors and cocatalysts have been widely used for photoelectrochemical (PEC) conversion of CO<sub>2</sub> gas to value-added chemicals such as formic acid (HCOOH). To date, however, the rational design of catalytic architecture enabling the reduction of <i>real</i> CO<sub>2</sub> gas to chemical has remained a grand challenge. Here, we report a unique photocathode consisting of CuS-decorated GaN nanowires (NWs) integrated on planar silicon (Si) for the conversion of H<sub>2</sub>S-containing CO<sub>2</sub> mixture gas to HCOOH. It was discovered that H<sub>2</sub>S impurity in the modeled industrial CO<sub>2</sub> gas could lead to the spontaneous transformation of Cu to CuS NPs, which resulted in significantly increased faradaic efficiency of HCOOH generation. The CuS/GaN/Si photocathode exhibited superior faradaic efficiency of HCOOH = 70.2% and partial current density = 7.07 mA/cm<sup>2</sup> at -1.0 V<sub>RHE</sub> under AM1.5G 1 sun illumination. To our knowledge, this is the first demonstration that impurity mixed in the CO<sub>2</sub> gas can enhance, rather than degrade, the performance of the PEC CO<sub>2</sub> reduction reaction.
Focus: Celebrated Optical Trick Goes Vibrational (2017)

A micromechanical device generates a series of precise, equally spaced vibration frequencies, analogous to the light of the “optical frequency comb,” which has dramatically improved precision measurements.
Intermolecular versus intramolecular interactions of Dictyostelium myosin: possible regulation by heavy chain phosphorylation. (1989)

Dictyostelium myosin has been examined under conditions that reveal intramolecular and intermolecular interactions that may be important in the process of assembly and its regulation. Rotary shadowed myosin molecules exhibit primarily two configurations under these conditions: straight parallel dimers and folded monomers. All of the monomers bend in a specific region of the 1860-A-long tail that is 1200 A from the head-tail junction. Molecules in parallel dimers are staggered by 140 A, which is a periodicity in the packing of myosin molecules originally observed in native thick filaments of muscle. The most common region for interaction in the dimers is a segment of the tail about 200-A-long, extending from 900 to 1100 A from the head-tail junction. Parallel dimers form tetramers by way of antiparallel interactions in their tail regions with overlaps in multiples of 140 A. The folded configuration of the myosin molecules is promoted by phosphorylation of the heavy chain by Dictyostelium myosin heavy chain kinase. It appears that the bent monomers are excluded from filaments formed upon addition of salt while the dimeric molecules assemble. These results may provide the structural basis for primary steps in myosin filament assembly and its regulation by heavy chain phosphorylation.
A new network model for miniaturized hairpin resonators and its applications (2002)

In this paper, miniaturized hairpin resonators are completely studied. Two designs for odd-mode and even-mode are derived from a new network model. The size and spurious response of this type of resonator are then minimized and controlled based on these two equations. Finally, a cross-coupled filter is designed by using these resonators to demonstrate one of the applications.
ESRF Experimental Report - 26-01-932 - Hydrolysis of X-Ser peptide promoted by molybdate (2012)

sponsorship: FWO/NWO
L'insertion dans l'Etre : la question de l'éducation dans la philosophie de Maurice Merleau-Ponty (2004)

International audience
Pharmaceutical tablet compression: measuring temporal and radial concentration profiles to better assess segregation (2022)

Concentration monitoring inside a tablet press feed frame is important not only to assess the composition of the powder blend compressed into tablets but also to detect quality affecting phenomena such as powder segregation. Near infrared spectroscopy has been successfully used to monitor powder concentration inside the feed frame; however, so far, this methodology does not provide information on local spatial variability, since it probes a very small area of powder sample. Near infrared chemical imaging (NIR CI) has the potential to improve process monitoring because it can simultaneously acquire a plurality of spectra covering nearly the entire width of the feed frame, thereby making it possible to detect local variations in powder concentration. The present work uses both NIRS and NIR CI to monitor the concentration of Ibuprofen and Ascorbic acid in multi-component mock pharmaceutical blends flowing through the feed frame of an industrial tablet press. The concentrations of Ibuprofen and Ascorbic acid were successfully monitored in multi-component powder blends. NIR spectral wavelength ranges and pre-treatments were simultaneously optimized via a genetic algorithm. N-way PLS approach for concentration monitoring was found to be more suitable than regular PLS when analyzing spectral images and provided the ability to visualize spatial segregation.
Screening and characterization of trehalose-oleate hydrolyzing lipase (2001)

Various soil samples were collected to screen the presence of microorganisms which have ability to degrade TOE. One strain (AKU-883) with good TOE degrading activity was isolated and identified as Burkholderia cepacia and the extracellular enzyme was purified to homogeneity. The purification was achieved by ultrafiltration, Super Q anion-exchange chromatography and Superdex 200HR gel-filtration in the presence of Triton X. The enzyme was purified to 85-fold, and specific activity of 4.910 kU mg protein(-1). The peak preparation on gel filtration showed a single band of 34 kDa on SDS-PAGE and native PAGE which indicate the monomeric nature of the enzyme. The pI of the enzyme was 6.3. The enzyme showed the maximum activity at pH 9 and 65 degrees C, and was stable in the range of pH 5--10 and up to 60 degrees C. Almost all the activity (92%) was kept after incubation for more than 1 week at 50 degrees C (pH 7.3). High activities remained even in water-miscible solvents such as ethanol, dimethyl formamide, diisopropyl ether, and dioxane. The N-terminal 16 amino acid residues were determined as A-N-G-Y-A-A-T-R-Y-P-I-I-L-V-G-G, which showed a consensus sequence for lipases from Burkholderia species. Thus the enzyme was concluded to be a kind of lipase.
Composite layers consisting of polyaniline and poly(o-phenylenediamine): Electrochemical deposition, electrochromic and electrocatalytic properties (2010)

The composite polymer layers consisting of polyaniline (PANI) and poly(o-phenylenediamine) (poly(o-PDA)) were electrodeposited on a platinum electrode by simultaneous electrochemical oxidation of corresponding monomers from aquaeous hydrochloric solutions. The growth of PANI and poly(o-PDA) occurs separately resulting in layers with two distinct, finely distributed phases. The first deposited layers are composed mainly of poly(o-PDA) and become richer in PANI as the electropolymerization proceeds. The aniline/o-PDA copolymer was not formed during electrodeposition, as evidenced by cyclic voltammetry and Fourier-transformed IR spectroscopy. It was demonstrated that the electrochromic properties of resulting composite layers are the combination of yellow/brown-reddish and green/dark blue observable color transitions which are characteristics of poly(o-PDA) and PANI, respectively. Electrocatalytic properties of the electrosynthesized composite layers were investigated on quinone/hydroquinone (Q/H2Q) redox system and it was shown that the composite layers increase the heterogeneous electron transfer rate with a magnitudes ranging from those obtained on pure poly(o-PDA) to those obtained on pure PANI layer.
Large magnetoresistance in magnetically frustrated ruthenates (2003)

A large negative magnetoresistance effect is found in Fe-doped ruthenates of perovskite and layered perovskite structures. These new materials are magnetically glassy, and can be derived from a parent compound that is either magnetic or nonmagnetic. The magnetoresistance is nearly linear with the magnetic field up to 9 T and is stronger at lower temperature. Atomic-level spin valves associated with Fe cations on B sites that regulate electron transport in response to an external magnetic field are suggested to be the mechanism responsible.
Microwave split-ring resonator array for imaging of near-surface material defects (2018)

This novel study shows that, compared to a single microwave split-ring resonator (SRR), the image quality and detection accuracy of near-surface material defects can be significantly improved with the use of an N × M - channel SSR array. An example 3 × 3 array of independently driven SRRs was modelled to image 2 mm wide near-surface cracks in concrete and aluminium with S-parameters recorded over a frequency span of 3.5-6.5 GHz. Images with improved quality were obtained with the new multi-channel SRR array. It is hoped that this is an initial step in the direction of implementing a near-surface microwave camera system prototype.
Oxidative Stress and the Amyloid Conundrum. What is the Connection? (2000)

In the sea of information for and against the role of amyloid in AD many of us have felt at times in akin circumstances. The hypothesis by Andorn and Kalaria that amyloid peptides could function both as antioxidants and pro-oxidants yet adds a new dimension of complexity to an already intricate problem in Alzheimers disease. These authors present evidence suggesting that various Aβ fragments can, under certain experimental conditions, behave as antioxidants by inhibiting ascorbate-induced lipid peroxidation of membrane fragment preparations obtained from postmortem human prefrontal and parietal cortex. These findings raise new and interesting issues regarding amyloid deposits in AD. During the last few years several laboratories have presented compelling evidence indicating that brains with AD are subject to a pervasive level of oxidative stress. One important set of data comes from in vitro models and suggests that the amyloid peptide, the main constituent of senile plaques, causes extensive degeneration and
Biological Activities and Nutraceutical Potentials of Water Extracts from Different Parts of Cynomorium coccineum L. (Maltese Mushroom) (2016)

Maltese Mushroom (Cynomorium coccineum L.) is a non-photosynthetic plant that has been used in traditional medicine for many centuries. In this paper, water extracts from the whole plant, external layer and peeled plant were studied to determine the main components responsible for its biological activities, i.e., its antimicrobial, antioxidant, and anti-tyrosinase activities; its cytotoxicity against mouse melanoma B16F10 cells; and its pro-erectile activity in adult male rats. The results of electron transfer and hydrogen transfer assays showed that the antioxidant activity was mainly due to anthocyanins in the external layer, whereas the external layer and peeled plant extracts both inhibited the microbial growth of several Gram-positive strains. In contrast, the whole plant extract had the highest anti-tyrosinase activity and exhibited pro-erectile activity when administered subcutaneously. Overall, this study elucidated which parts of Maltese Mushroom are responsible for its antimicrobial, antioxidant, and anti-tyrosinase activities and thus which extracts have potential for use in nutraceutical formulations.
DEVELOPMENT OF AN AGGREGATE MODEL OF URBANIZED AREA TRAVEL BEHAVIOR: PHASE 1 (1976)

This is the final report of Phase I of a project to develop an aggregated travel demand model for use in urbanized area prediction. The model is designed to be applied in the context of the Department of Transportation TRANS model and is based on the aggregation to the urban area wide level of disaggregate travel demand models. Phase I of the project was concerned with the investigation of alternative aggregation procedures. The results of this theoretical and empirical investigation are summarized in this report. In Phase II of this project the results of Phase I will be used to develop an overall aggregation procedure operating on a full set of disaggregate travel demand models. This report describes the implications of the Phase I results and outlines the approach for the overall aggregate forecasting process to be developed in Phase II.
Efficacy of icatibant treatment in patients with hereditary angio-oedema type I resistant to treatment with C1 inhibitor concentrate (2011)

International audience
Optimal geographic caching in finite wireless networks (2016)

Cache-enabled device-to-device (D2D) networks turn memory of the devices at the network edge, such as smart phones and tablets, into bandwidth by enabling asynchronous content sharing directly between proximate devices. Limited storage capacity of the mobile devices necessitates the determination of optimal set of contents to be cached on each device. In order to study the problem of optimal cache placement, we model the locations of devices in a finite region (e.g., coffee shop, sports bar, library) as a uniform binomial point process (BPP). For this setup, we first develop a generic framework to analyze the coverage probability of the target receiver (target-Rx) when the requested content is available at the k <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sup> closest device to it. Using this coverage probability result, we evaluate optimal caching probability of the popular content to maximize the total hit probability. Our analysis concretely demonstrates that optimal caching probability strongly depends on the number of simultaneously active devices in the network.