gebhart/patrepeval huggingface dataset:
Light reallocation for high contrast projection using an analog micromirror array (2010)

We demonstrate for the first time a proof of concept projector with a secondary array of individually controllable, analog micromirrors added to improve the contrast and peak brightness of conventional projectors. The micromirrors reallocate the light of the projector lamp from the dark parts towards the light parts of the image, before it reaches the primary image modulator. Each element of the analog micromirror array can be tipped/tilted to divert portions of the light from the lamp in two dimensions. By directing these mirrors on an image-dependent basis, we can increase both the peak intensity of the projected image as well as its contrast.In this paper, we describe and analyze the optical design for projectors using this light reallocation approach. We also discuss software algorithms to compute the best light reallocation pattern for a given input image, using the constraints of real hardware. We perform extensive simulations of this process to evaluate image quality and performance characteristics of this process. Finally, we present a first proof-of-concept implementation of this approach using a prototype analog micromirror device.
Individual Platelet Adhesion Assay: Measuring Platelet Function and Antiplatelet Therapies in Whole Blood via Digital Quantification of Cell Adhesion (2013)

Widespread monitoring of platelet function and the effect of antiplatelet drugs will improve outcomes in cardiovascular patients, but platelet function testing is not routine in clinical practice. We report a rapid, accurate methodology to quantify platelet-protein interactions: a microarray of contact-printed 6-μm fibrinogen dots on a transparent substrate binds platelets from whole blood, one platelet per dot. The fractional occupancy of an array of fibrinogen dots after a predefined incubation time quantitatively assays platelet adhesion to the protein matrix. We demonstrate this technique by measurement of platelet adhesion to fibrinogen as a means to quantify the effect of the P2Y12 and αIIbβ3 receptor inhibitors cangrelor and abciximab, respectively, both in vitro--by incubating the drug with a freshly drawn blood sample--and in blood from patients treated with antiplatelet agents. The effects of single- and dual-antiplatelet therapy are also assessed. Results from this platelet-binding assay are well correlated with standard techniques including flow cytometry and light transmission aggregometry. This assay technology, readily integrated with microfluidic platforms, is generally applicable to the assay of cell-protein interactions and promises more effective, rapid assay of drug effects in cardiovascular disease patients.
Evaluation of a Rhodomyrtus tomentosa ethanolic extract for its therapeutic potential on Staphylococcus aureus infections using in vitro and in vivo models of mastitis (2019)

An ethanolic extract from Rhodomyrtus tomentosa leaves (RTL) was studied as a natural alternative to control Staphylococcus aureus, which is an important pathogen responsible for bovine mastitis. The minimal inhibitory concentrations (MICs) of the RTL extract and of rhodomyrtone, a pure compound isolated from the plant, were determined by a microdilution method. Rhodomyrtone and the RTL extract exhibited antibacterial activity against S. aureus, including its persistent phenotype (SCV: small-colony variant) and a biofilm hyperproducer strain, with MICs of 0.25-0.5 and 8-16 µg/mL, respectively. Time-kill kinetics showed a strong bactericidal activity for both the RTL extract- and rhodomyrtone-treated bacteria at 2 × MIC as early as 4 h post-exposure. An additive effect of the extract at 0.5 × MIC was observed in a combination with oxytetracycline or pirlimycin against S. aureus by showing a 64- to 128-fold reduction in antibiotic MICs. Moreover, the RTL extract significantly decreased the number of intracellular SCVs inside bovine mammary epithelial cells. However, the extract or its combination with pirlimycin only slightly improved the activity of pirlimycin against the bacterial colonization of mouse mammary glands. In vitro MICs determined in the presence of casein indicated that the limited activity of the RTL extract in the murine model of mastitis could be linked to neutralization of active components by milk proteins. While the RTL extract showed interesting antibacterial properties in vitro, to be considered as an alternative to antibiotics in dairy farms, formulation studies are needed to cope with the observed reduction of activity in vivo.
Nondestructive Evaluation of Rayleigh Pitch-Catch Contact Ultrasound Waves on Impacted-Damaged Composites (2007)

In particular, CFRP (carbon fiber reinforced plastics) composite materials have found wide applicability because of their inherent design flexibility and improved material properties. CFRP composites were manufactured from uni-direction prepreg sheet in this paper. However, impacted composite structures have 50-75% less strength than undamaged structures. It is desirable to perform nondestructive evaluation to assess material properties and part defect in order to ensure product quality and structural integrity of CFRP. In this work, a CFRP composite material was nondestructively characterized and a pitch-catch technique was developed to measure impacteddamaged area using an automated-data acquisition system. Also one-sided mode was performed to scan defect both manual contact measurement and an immersion tank. It is found a pitch-catch signal was found to be more sensitive than normal incidence backwall echo of longitudinal wave to subtle flaw conditions in the composite, including fiber orientation, low level porosity, ply waviness, and cracks. The paper describes the depth of the sampling volume with the head-to-head miniature Rayleigh probes and also ultrasonic C-scan images are acquired experimentally using one-sided measurement and a conventional scanner.
1545: ASSOCIATION OF HYPEROXIA WITH SURVIVAL AFTER CARDIAC ARREST IN PEDIATRIC RESUSCITATION COLLABORATIVE (2019)

Buysse, Corinne; de Jonge, Rogier; Scholefield, Barney; Niles, Dana; Nadkarni, Vinay; Topjian, Alexis Author Information
Near Edge X‐Ray Absorption Fine Structure (NEXAFS) Studies of Copper Ion‐Containing PAMAMOS Dendrimer Networks (2005)

Abstract Summary: The interaction of Cu 2+ with C, N and O moieties in nanocomposites containing copper ions complexed in poly(amidoamine‐organosilicon), PAMAMOS, dendrimer networks was characterized using near edge X‐ray absorption fine structure (NEXAFS). The effects on the 1s → π * and 1s → σ * orbital transitions were determined at the C, N and O K edges. The influence of Cu 2+ on the transitions of 1s → π *(NH) at 401 eV, and 1s → σ *(NC) type transitions at 412 eV within the N edge increased with increasing Cu 2+ content up to the theoretical limit of the copper‐accommodating capacity of the PAMAMOS dendrimer used. As ligands, the carbonyls were found to saturate at much lower Cu 2+ concentrations compared with those associated with N. NEXAFS spectrum of a PAMAMOS[4,1]DMOMS dendrimer network. image NEXAFS spectrum of a PAMAMOS[4,1]DMOMS dendrimer network.
Combustion characteristics of fine-ground coal. Final report, March 1, 1981-August 31, 1982 (1983)

Orbitofrontal cortex is associated with many psychiatric disorders. Better anatomical and functional characterization of the orbitofrontal cortex and its connections will improve our knowledge about these diseases.
Impact of 24 months of androgen deprivation therapy (ADT) on physical function in men with nonmetastatic prostate cancer. (2011)

4640 Background: Use of ADT has been shown to adversely affect self-reported and objective physical function within 3 months of initiation; declines persist at 12 months. Few studies have examined physical function with ongoing ADT use beyond 12 months. Methods: In this extension of our prior study, men age 50 or older with non-metastatic prostate cancer (PC) who were on continuous ADT were followed along with two control groups (PC, no ADT; healthy controls) matched on age, education, and baseline function. Physical function was assessed with the 6-minute walk test (6MWT), grip strength, and the Timed Up and Go (TUG) test, representing endurance, upper extremity strength, and lower extremity strength, respectively. Self-reported physical function was measured with the Medical Outcomes Study SF-36. Assessments were done at baseline and at 3, 6, 12, 18, and 24 months. Mixed effects regression models were used, adjusting for baseline function and other covariates. Results: 87 patients on ADT, 86 PC controls, and 86 healthy controls were enrolled (mean age 69.1 y, range 50-87). At baseline, all three groups were similar in age and physical function (all ANOVA p>0.05) and most patients reported excellent health and functional status. The decline in 6MWT in ADT users within the first 3 months compared to controls persisted up to 24 months (p=0.0046), and remained stable after initially improving in both control groups. Grip strength declined sharply in the ADT group by 3 months and remained stable up to 24 months (p<0.001), whereas both control groups were relatively stable or slightly improved over time. There was a slight worsening of TUG scores in the ADT group over 24 months compared to controls (p=0.0013), whereas TUG scores were unchanged in both control groups (p>0.10). Self-reported physical function continued to decline in ADT users (p=0.0003), remained stable in PC controls, and improved slightly in healthy controls over 24 months. Conclusions: Initial declines in both objective and self-reported physical function with continuous ADT use persist for at least 24 months. Greater use of exercise interventions should be considered in men starting ADT.
Identification of intragenic mutations in the Von Hippel — Lindau disease tumour suppressor gene andcorrelation with disease phenotype (1994)

Von Hippel-Lindau (VHL) disease is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign neoplasms, most frequently retinal, cerebellar and spinal haemangioblastoma, renal cell carcinoma, phaeochromocytoma and pancreatic tumours. We have previously detected large germline deletions by Southern analysis and pulsed field gel electrophoresis in 19% and 3% of VHL patients respectively. We have now investigated 94 VHL patients without large deletions for intragenic mutations using single strand conformation polymorphism and heteroduplex analysis. Forty different mutations were identified in 55 unrelated kindreds. A wide variety of mutations were detected including missense (n = 19), nonsense (n = 6), frameshift deletions or insertions (n = 12), in frame deletions (n = 2) and a splice donor site mutation (n = 1). The two most frequent mutations, were missense mutations at codon 238 (Arg-->Gln and Arg-->Trp) and were detected in five and four unrelated kindreds, respectively. VHL disease shows marked phenotypic variability and although phaeochromocytoma occurs in only about 7% of patients, marked interfamilial differences are observed. We examined the relationship between VHL gene mutations and phenotype in 65 kindreds. Large deletions or intragenic mutations predicted to cause a truncated protein were found in 36 of 53 families without phaeochromocytoma but only two of 12 families with phaeochromocytoma (chi 2 = 8.58; P < 0.01). Of 12 families with phaeochromocytoma 10 had missense mutations compared with 13 of 53 kindreds without phaeochromocytoma (chi 2 = 12.33; P < 0.001). In particular, substitution of an arginine at codon 238 (Arg-->Trp or Arg-->Gln) was associated with a high risk (62%) of phaeochromocytoma.(ABSTRACT TRUNCATED AT 250 WORDS)
Models for continuous and hybrid system simulation (2004)

The DEVS formalism was defined as a method for modeling and discrete event systems. DEVS theory evolved and it was recently upgraded in order to permit modeling of continuous and hybrid systems. Here, we present a first experience on the use of two of the existing methods for defining continuous variable DEVS models (namely, the QDEVS and the GDEVS formalisms), to develop continuous and hybrid systems simulations. We show how to model these dynamic systems under the discrete event abstraction. Examples of model simulations with their execution results are included. An experimental analysis on quantization methods within models is also presented.
Small changes, big effects (2017)

BACKGROUND The transition from complete aortic occlusion during resuscitative endovascular balloon occlusion of the aorta can be associated with hemodynamic instability. Technique refinements and new technologies have been proposed to minimize this effect. In order to inform new techniques and technology, we examined the relationship between blood pressure and aortic flow during the restoration of systemic circulation following aortic occlusion at progressive levels of hemorrhage. METHODS An automated supraceliac aortic clamp, capable of continuously variable degrees of occlusion, was applied in seven swine. The swine underwent stepwise removal of 40% of their total blood volume in four equal aliquots. After each aliquot, progressive luminal narrowing to the point of complete aortic occlusion was achieved over 5 minutes, sustained for 5 minutes, and then released over 5 minutes. Proximal and distal blood pressure and distal aortic flow were continuously recorded throughout the study. RESULTS Upon release of the clamp, hyperemic aortic flow was observed following 10% and 20% hemorrhage (1,599 ± 785 mL/min, p < 0.01; and 1,070 ± 396 mL/min, p < 0.01, respectively). Proximal blood pressure exhibited a nonlinear relationship to aortic flow during clamp removal; however, distal blood pressure increased linearly with distal flow upon clamp opening across all hemorrhage volumes. CONCLUSIONS Hyperemic blood flow following return of circulation may contribute to cardiovascular collapse. Reintroduction of systemic blood flow after aortic occlusion should be guided by distal blood pressure rather than proximal pressure. Awareness of hemodynamic physiology during aortic occlusion is of paramount importance to the clinical implementation of next-generation resuscitative endovascular balloon occlusion of the aorta techniques and technologies.
Physical activity in patients with stable coronary heart disease: an international perspective (2013)

In this international study, low physical activity was only partly explained by cardiovascular symptoms. Potentially modifiable societal and health system factors are important determinants of physical inactivity in patients with chronic CHD.
Improving sequence-based modeling of protein families using secondary structure quality assessment (2021)

Abstract Motivation Modeling of protein family sequence distribution from homologous sequence data recently received considerable attention, in particular for structure and function predictions, as well as for protein design. In particular, Direct Coupling Analysis, a method to infer effective pairwise interactions between residues, was shown to capture important structural constraints and to successfully generate functional protein sequences. Building on this and other graphical models, we introduce a new framework to assess the quality of the secondary structures of the generated sequences with respect to reference structures for the family. Results We introduce two scoring functions characterizing the likeliness of the secondary structure of a protein sequence to match a reference structure, called Dot Product and Pattern Matching. We test these scores on published experimental protein mutagenesis and design dataset, and show improvement in the detection of non-functional sequences. We also show that use of these scores help rejecting non-functional sequences generated by graphical models (Restricted Boltzmann Machines) learned from homologous sequence alignments. Availability Supplementary Materials, Data and Code available at https://github.com/CyrilMa/ssqa . Contact cyril.malbranke@ens.fr Abstract Figure
AEROBIC EXERCISE ACCELERATES WOUND HEALING AMONG STRESSED OLDER WOMEN, BUT NOT STRESSED OLDER MEN (2017)

Aging and psychological stress are associated with impaired wound healing. Aerobic exercise (AE) has been associated with accelerated rates of wound healing among healthy older adults. This study evaluated the influence of AE on wound healing among healthy, stressed older adults. 77 community-residing older adults (mean age=65.0±7.9 years; range: 55–84 years; 64% women) reporting elevated daily stress were randomly assigned to an AE group or a balance and flexibility (BF) control group. Both groups attended sessions 3x/week for 12 weeks. Participants completed comprehensive assessments prior to randomization and at study conclusion, including exercise capacity (VO2peak) and psychological stress (Perceived Stress Scale-10), as well as additional self-report and biological markers. After 2 weeks of group sessions (AE or BF), participants underwent a standardized experimental wound procedure, and wounds were measured 3x/week until healed to calculate wound healing rate. Repeated measures analysis of variance (ANOVA) revealed a time by group interaction for VO2peak [F(1,66)=10.07, p=.002], with a 13% gain in AE versus 2% in BF. As expected, in the full sample older age was associated with slower wound healing (r=.24, p=.040). Surprisingly, ANOVA revealed no difference in wound healing rate across groups, but wound healing was faster among men than among women [F(1,67)=5.46, p=.022]. Also, there was a significant sex by group interaction [F(1,67)=6.15, p=.016]: among women, wounds healed faster in the AE group, but among men wounds healed faster in the BF group. Thus, among stressed older adults, AE may be more relevant for wound healing of women than of men.
Design of external matching unit with high power vacuum windows for the FAST-ICRH system (2009)

FAST (Fusion Advanced Studies Torus) is a new tokamak machine for the researches on Fusion Energy, proposed by the Italian Fusion Association as a satellite Tokamak for accompanying the International Thermonuclear Experimental Torus (ITER) programme and to explore fusion relevant technologies. In FAST peculiar aspect of the physics of burning plasma scenarios will be investigated by accelerating fast ions through additional heating systems. The main heating source is the Ion Cyclotron Resonance Heating (ICRH) System that will couple to the plasma about 30 MW of power in the 30–90 MHz frequency range. The launcher consists in eight current straps arranged in four rows. A load tolerant External Conjugate-T concept with high resilience to the loading variation due to the plasma perturbation is being studied to match the low impedance of the launcher to the feeding coaxial cables (Zo= 30 Ω). The whole Matching System made by passive RF components (hybrids couplers, paralleled stubs and shifters, T-junction and relative shifters) has been carefully evaluated and the results presented in the paper. The RF design of a double conical vacuum window and the evaluation of the power handling capability of the external matching will be presented.
Antibody responses toPlasmodium falciparumsporozoite-, liver- and blood-stage synthetic peptides in migrant and autochthonous populations in malaria endemic areas. (1995)

This study evaluates the differences in host immune responses to defined plasmodial antigens in four geographically different regions in which malaria is endemic. Sera from 527 individuals were tested for the presence of antibodies specific for three types of plasmodial antigen: liver-stage antigen (LSA-1), blood-stage antigen (SPF 70) and circumsporozoite (CS) antigen (NANP)4. The individuals taking part in the study comprised: patients with transfusional malaria due to Plasmodium falciparum or P. vivax; non-immune migrants residing in an endemic area in Rondônia; Amazonian Indians from the states of Pará (Xingu PA) and Mato Grosso (Xingu MT); people living in a hyperendemic area in Africa (Burkina-Faso); and controls that had never been to a malaria endemic area. None of the transfusional sera displayed antibodies against sporozoite or to liver stage antigen, although 80% of the P. falciparum transfusional malaria sera contained IgG antibodies against the blood-stage peptide. A low percentage of Indians from Xingu PA and of non-immune migrants displayed antibodies against liver-stage (27% and 17%) and sporozoite (11% or d 12%) peptides, although a greater frequency of antibodies against blood-stage peptide (50% and 49%) was observed in both cases. Indians from Xingu MT exhibited a greater frequency of antibodies against liver, sporozoite and blood-stage peptides (45%, 50% and 58%). Only hyperimmune African individuals exhibited higher percentages of antibodies against liver- (64%) and blood-stage antigens (87%), contrasting with a low frequency of antibodies against the CS repeat (33%). Taken together, the present data confirm that Rondonian migrants and Indians from Xingu PA constitute populations with limited exposure and immunity to P. falciparum malaria infection and conversely, Xingu MT Indians and Africans have been more exposed to malaria infection. In conclusion this study indicates that the immune response to these malaria parasite peptides can be used to assess malaria transmission in epidemiological surveys.
Method for Estimating Locations of Service Problem Causes in Service Function Chaining (2015)

We propose a method for estimating the locations of the causes of failure or deterioration in quality in the service function chains (SFCs) of datacenter networks by using tests packets. Our method is especially effective in service-quality deterioration where no alarms are notified from physical and virtual components. This method models SFC configurations by creating a correlation ID, which identifies a correlation between physical network elements and virtualized elements of the SFC components to enable us to find the components common to all SFCs that are either in failure or deteriorating. We consider such common components as locations where service problems can occur in SFCs. As a result of applying this method to SFCs in datacenter networks, it drastically reduced the number of candidate causes and computation time.
Vigilance for Medical Products of Human Origin—Progress on the Notify Library’s Global Effort to Share Information and Learning (2021)

Notify Library is the first open-access, searchable database of systematically identified reports of disease transmission and other adverse occurrences arising from the donation and clinical application of MPHO.
Neuroprotective effect by Dammishimgyu-herbal acupuncture against H2O2-induced apoptosis in human neuroblastoma, SH-SY5Y cells (2007)

These results suggest that DMSG-herbal acupuncture shows protective effect against H(2)O(2)-induced neuronal damage.
Metal‐Organic Frameworks: Meso‐Porous Frameworks (2014)

Abstract Metal–organic frameworks (MOFs) have attracted great attention as a new type of prospective materials with various metrics and functionalities. In comparison with microporous MOFs (pore size &lt; 2 nm), mesoporous metal–organic frameworks (mesoMOFs) have largely expanded the utility of MOFs on diverse fields because of their enlarged pore size (2–50 nm) as well as the special characteristics of the mesoporous cages or channels, such as the shape and chemical environments. Herein the strategies for the design and synthesis of mesoMOFs and the structural features of representative mesoMOFs under different catalogs are reviewed. Recent advances of mesoMOFs in diverse applications are also covered, such as gas storage and separation, catalysis, sensing and drug delivery, and the relationship between their functions and the structural specificities are discussed as well.