gebhart/patrepeval huggingface dataset:
Towards Single-Shot Characterization of Near-Resonant LWFA in a Differentially-Pumped Gas Cell (2004)

We report on progress in the development of a single‐shot diagnostic for measuring near‐resonant laser‐driven wakefields. The development entails the following critical steps: 1. Increase in laser pulse energy 2. development and characterization of a differentially pumped gas cell 3. development of a single‐shot diagnostic with low phase noise 4. analysis of laser/plasma parameter space for maximizing the measured phase shift. As a result of this development we expect to be have detection sensitivity of 50 – 100 mrad and we expect to be able produce and measure wakefields with dne/ne∼1 and phase shifts of several hundred mrad.
Silencing of OsCV (chloroplast vesiculation) maintained photorespiration and N assimilation in rice plants grown under elevated CO2 (2020)

High CO<sub>2</sub> concentrations stimulate net photosynthesis by increasing CO<sub>2</sub> substrate availability for Rubisco, simultaneously suppressing photorespiration. Previously, we reported that silencing the chloroplast vesiculation (cv) gene in rice increased source fitness, through the maintenance of chloroplast stability and the expression of photorespiration-associated genes. Because high atmospheric CO<sub>2</sub> conditions diminished photorespiration, we tested whether CV silencing might be a viable strategy to improve the effects of high CO<sub>2</sub> on grain yield and N assimilation in rice. Under elevated CO<sub>2</sub> , OsCV expression was induced, and OsCV was targeted to peroxisomes where it facilitated the removal of OsPEX11-1 from the peroxisome and delivered it to the vacuole for degradation. This process correlated well with the reduction in the number of peroxisomes, the decreased catalase activity and the increased H<sub>2</sub> O<sub>2</sub> content in wild-type plants under elevated CO<sub>2</sub> . At elevated CO<sub>2</sub> , CV-silenced rice plants maintained peroxisome proliferation and photorespiration and displayed higher N assimilation than wild-type plants. This was supported by higher activity of enzymes involved in NO<sub>3</sub><sup>-</sup> and NH<sub>4</sub><sup>+</sup> assimilation and higher total and seed protein contents. Co-immunoprecipitation of OsCV-interacting proteins suggested that, similar to its role in chloroplast protein turnover, OsCV acted as a scaffold, binding peroxisomal proteins.
1st International Workshop on Replication in Empirical Software Engineering Research (RESER) (2010)

The RESER 2010 workshop provides a venue in which empirical Software Engineering researchers may present and discuss theoretical foundations and methods of replication, as well as the results of replicated studies.
A fast mutual exclusion algorithm (1987)

A new solution to the mutual exclusion problem is presented that, in the absence of contention, requires only seven memory accesses. It assumes atomic reads and atomic writes to shared registers.
ChemInform Abstract: Stereoselective Total Synthesis of (+)‐Myriocin from D‐Mannose. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
From system goals to intruder anti-goals: attack generation and resolution for security requirements engineering (2003)

Caring for security at requirements engineering time is a message that has finally received some attention recently. However, it is not yet very clear how to achieve this systematically through the various stages of the requirements engineering process. We briefly introduce some of the requirements such a process should meet for high assurance to be provided from the resulting requirements product. A constructive approach to security requirements elicitation, modeling and analysis is then outlined as an attempt to address such meta-requirements. The approach is based on a framework we developed before for generating and resolving obstacles to requirements achievement. Our framework integrates intentional obstacles (or &amp;quot;antigoals&amp;quot;) set up by attackers to break security goals. Attack trees are derived systematically through anti-goal refinement until leaf nodes are reached that are software vulnerabilities observable by the attacker or antirequirements implementable by this attacker. New security requirements are derived by resolution of the attack trees generated thereby. 1.
138-04: Topography of atrial fibrosis in patients with paroxysmal and persistent atrial fibrillation undergoing ablation (2016)

Introduction: With advances in cardiac imaging, ventricular and atrial myocardial tissue can be accuratelly studied and areas of fibrosis identyfied. The role of atrial fibrosis on atrial fibrillation (AF) genesis and perpetuation is being evaluated. The aim of this anaysis is to analyse whether fibrosis is more frequently found in specific areas. Results: Ninety-four patients were included. Fibrosis prevalence in each segment is expressed in figure 1d as well as the mean score. The severity of fibrosis is higher in posterior than in anterior wall (sum of scores 2.49 ± 2.7 vs 0.33 ± 0.9; p < 0.001). The incidence of fibrosis in the region incorporating segments 2 and 5 is higher than in the other sites of posterior wall (segments 1, 3 and 4) considered together (80% vs 43%, p = 0.001), as well as the score of severity (1.02 ± 0.8 vs 0.45 ± 0.7; p < 0.001). Conclusions: Fibrosis was more frequently identified in the region near the antrum of left inferior pulmonar vein and mitral isthmus than in any other site in the atrium. Incidence of fibrotic tissue infiltration is higher in posterior wall than in anterior one and with higher grades of severity.
Intramolecular catalysis in the enolisation of β-piperidinopropiophenone and its methiodide derivative (1981)

Measurements have been made on the rates of iodination of β-piperidinopropiophenone and its methiodide derivative, and on the rates of bromination of β-piperidinopropiophenone. The rates are independent of halogen concentration, except at low pH and high iodide concentrations when the iodination reactions are reversible, and represent the rate of ionisation or enolisation of the substrates. The reactions are base-catalysed and catalytic constants for a number of bases have been determined. The rates of ionisation of the protonated and N-methylated aminoketones are closely similar, and are up to 4 000 times larger than those of corresponding reactions of the neutral aminoketone and acetophenone. The close similarity between the reactivities of the protonated and N-methylated aminoketone suggests that the effect is due to an intramolecular electrostatic stabilisation of the negative charge developing on the carbonyl oxygen in the transition state. The results are discussed in relation to those of earlier studies on related systems.
MicroRNAs regulate the expression of the alternative splicing factor nPTB during muscle development (2007)

Alternative pre-mRNA splicing determines many changes in gene expression during development. Two regulators known to control splicing patterns during neuron and muscle differentiation are the polypyrimidine tract-binding protein (PTB) and its neuronal homolog nPTB. These proteins repress certain exons in early myoblasts, but upon differentiation of mature myotubes PTB/nPTB expression is reduced, leading to increased inclusion of their target exons. We show here that the repression of nPTB expression during myoblast differentiation results from its targeting by the muscle-restricted microRNA miR-133. During differentiation of C2C12 myoblasts, nPTB protein but not mRNA expression is strongly reduced, concurrent with the up-regulation of miR-133 and the induction of splicing for several PTB-repressed exons. Introduction of synthetic miR-133 into undifferentiated C2C12 cells leads to a decrease in endogenous nPTB expression. Both the miR-133 and the coexpressed miR-1/206 microRNAs are extremely conserved across animal species, and PTB proteins are predicted targets for these miRNAs in Drosophila, mice, and humans. There are two potential miR-133-responsive elements (MRE) within the nPTB 3' untranslated region (UTR), and a luciferase reporter carrying this 3' UTR is repressed by miR-133 in an MRE-dependent manner. Transfection of locked nucleic acid (LNA) oligonucleotides designed to block the function of miR-133 and miR-1/206 increases expression of nPTB and decreases the inclusion of PTB dependent exons. These results indicate that miR-133 directly down-regulates a key splicing factor during muscle development and establishes a role for microRNAs in the control of a developmentally dynamic splicing program.
Bivalent anti-CD3 Fab dimers drive T cells into a highly efficient fratricide with potential clinical application (2019)

Abstract Non-covalent anti-CD3 Fab dimers (Bi-Fabs) bind to the TCR/CD3 complex and activate T cells. In the presence of proper co-stimulation, anti-CD3 Bi-Fabs promote T cell cycling and acquisition of effector functions on CD4 and CD8 T cells more robustly than other bivalent antibody species like F(ab′)2 and mAb with the same specificity. Surprisingly, the net effect of anti-CD3 Bi-Fab treatment on T cells in vitro is contraction of CD4 and CD8 T cells, via AICD. This is in contrast with the net T cell proliferation observed with soluble anti-CD3 mAbs that are stimulatory in the presence of proper co-stimulation. Bi-Fab binding to the TCR/CD3 complex, and direct cellular contact with Bi-Fab engaged T cells, are required to observe the net contraction of treated T cells. Using perforin-deficient T cells, and Fas-FasL blockade, we show this net contraction results from T cell apoptosis via Fas-FasL and CTL degranulation. Structural studies on Bi-Fabs suggest a rigid rod like structure. We hypothesize that the rigid rod allows for a potent crosslinking structure with both paratopes from the anti-CD3 Fabs capable to engage effector T cells on fratricide. In vivo, mice injected with anti-CD3 Bi-Fabs present depletion of T cells from blood, and absence of any adverse effects derived from T cell activation like cytokine storm. We have begun exploring the therapeutic potential of T cell depletion in mouse models of autoimmune disease with promising results.
Well‐Defined, Reversible Boronate Crosslinked Nanocarriers for Targeted Drug Delivery in Response to Acidic pH Values and cis‐Diols (2012)

Geliefert wie bestellt: Micellen, die über Boronatester reversibel vernetzt sind (siehe Schema), sind in vivo und in vitro stabil, sodass die vorzeitige Freisetzung des Wirkstoffs unter physiologischen Bedingungen minimiert ist. Nach Erreichen des Tumors wird die Freisetzung des Wirkstoffs (Sterne im Schema) durch Spaltung der Boronatester unter den sauren Bedingungen in der Umgebung des Tumors oder im Zellinneren oder durch die Verabreichung von Mannit aktiviert.
Freezing phenomenon in patients with parkinsonian syndromes (1997)

Freezing is a common symptom in parkinsonian syndromes, but its association with different causes of parkinsonism as well as with other symptoms has never been investigated. We conducted a database survey of the occurrence of freezing in parkinsonism. Of 347 patients with a clinical diagnosis of parkinsonism other than idiopathic Parkinson's disease and with specific data regarding freezing, 158 patients had freezing (46%). Freezing was significantly associated with progression of the disease as rated on the Hoehn & Yahr scale [odds ratio (OR), 1.69; p < 0.004]. Gender was not a risk factor for the development of freezing. Patients with drug-induced parkinsonism were at a very low risk for developing freezing (p < 0.00001; OR, 0.1). Freezing was found in a high frequency in patients with vascular parkinsonism (57%), normal-pressure hydrocephalus (56%), and generally in the group of patients who had parkinsonism resulting from neurodegenerative diseases (progressive supranuclear palsy, multiple system atrophy, and corticobasal ganglionic degeneration; 45%). Freezing was significantly associated with the presence of dementia, incontinence, and tachyphemia (OR, 2.01, 1.7, and 5.09, respectively).
Negative Electron Transfer Dissociation Fourier Transform Mass Spectrometry of Glycosaminoglycan Carbohydrates (2011)

Electron transfer through gas phase ion-ion reactions has led to the widespread application of electron- based techniques once only capable in ion trapping mass spectrometers. Although any mass analyzer can in theory be coupled to an ion-ion reaction device (typically a 3-D ion trap), some systems of interest exceed the capabilities of most mass spectrometers. This case is particularly true in the structural characterization of glycosaminoglycan (GAG) oligosaccharides. To adequately characterize highly sulfated GAGs or oligosaccharides above the tetrasaccharide level, a high resolution mass analyzer is required. To extend previous efforts on an ion trap mass spectrometer, negative electron transfer dissociation coupled with a Fourier transform ion cyclotron resonance mass spectrometer has been applied to increasingly sulfated heparan sulfate and heparin tetrasaccharides as well as a dermatan sulfate octasaccharide. Results similar to those obtained by electron detachment dissociation are observed.
Defeitos da B-Oxidação Mitocondrial: Um Caso Fatal de Deficiência em 3-Hidroxi-Acil-CoA Desidrogenase de Cadeia Longa. (LCHAD) (2014)

Descreve-se um caso fatal de deficiência em 3-hidroxi-acil-CoA desidrogenase de cadeia longa (LCHAD) diagnosticado numa criança de 8 meses de idade, segunda filha de um casal jovem, saudável e consanguíneo. Os primeiros sintomas manifestaram-se aos 6,5 meses de idade ao entrar em coma hipoglicémico não cetótico do qual recupera após infusão i.v. de glucose. Detectou-se hepatomegália e posteriormente cardiomegália. A presença de acidúria 3-hidroxi-dicarboxílica foi confirmada após teste de jejum prolongado de 13th e o estudo enzimático efectuado em cultura de fibroblastos de biópsia de pele confirmou o déficit em LCHAD.
Importance of macrocyclic ring deformation in the facile aerial oxidation of phenolic porphyrins (1987)

Unlike its metal-free precursor and NiII analogue, meso-tetrakis(3,5-di-t-butyl-4-hydroxyphenyl)- porphyrinatopalladium(II) undergoes very little aerial oxidation in basified dichloromethane, owing to metal-enforced planarity of the porphyrin macrocycle, as shown by crystal structure determinations of the two complexes.
Design & characterization of an antenna system for UWB-MIMO communications systems (2010)

International audience
Competition in Cross-situational Word Learning: A Computational Study (2020)

Children learn word meanings by tapping into the commonalities across different situations in which words are used and overcome the high level of uncertainty involved in early word learning experiences. We propose a modeling framework to investigate the role of mutual exclusivity bias - asserting one-to-one mappings between words and their meanings - in reducing uncertainty in word learning. In a set of computational studies, we show that to successfully learn word meanings in the face of uncertainty, a learner needs to use two types of competition: words competing for association to a referent when learning from an observation and referents competing for a word when the word is used. Our work highlights the importance of an algorithmic-level analysis to shed light on the utility of different mechanisms that can implement the same computational-level theory.
Non-inherited maternal antigens, pregnancy, and allotolerance (2014)

Non-inherited maternal antigens (NIMA) are those protein products derived from polymorphic genes that the mothers express but not the offspring. During normal human pregnancy, a bidirectional regulation occurs in such a way that the maternal immune system tolerates the inherited paternal antigens (IPA) expressed by the fetus and the developing fetal immune system tolerates NIMA. The process by which the described bidirectional regulation is developed is related to microchimerism, due to the bidirectional traffic of cells allowed by the decidua-trophoblast interface. An extensive body of knowledge from the transplantation and pregnancy physiology fields suggests a role for microchimerism and NIMA exposure in the development of NIMA-specific alloresponse regulation, which may include transforming growth factor β (TGF-β) as well as interleukin (IL)-10 and IL-35, producing peripheral T regulatory lymphocytes. The induction of this NIMA-specific allotolerance is called the "NIMA effect." Some experimental data suggest the existence of a "split tolerance" phenomenon associated with NIMA effect, in which regulation of NIMA-specific indirect pathway is induced without tolerogenic impact on the direct pathway. In this review, the most relevant literature about the immunological phenomena underlying the NIMA effect is discussed, including the most recent proposals about the role played by antigen-acquisition and the semi-direct pathway of allorecognition.
Bioinspired Molecular Electrets: Bringing Proteomic Approaches to Charge-Transfer Systems (2017)

Controlling charge transfer (CT) at a molecular level is immensely important for energy and electronic applications. Electrets, which are inherently dielectrics, possess ordered electric dipoles. That is, electrets are electrostatic analogies of magnets and they offer key paradigms for steering photogenerated charge carriers, usually away from each other, improving charge separation efficiencies. As bioinspired molecular electrets, anthranilamides possess an intrinsic dipole moment originating from their ordered amide and hydrogen bonds. The aromatic residues and extended π-conjugation along the backbone provides a means for long-range CT. Composed of non-native amino acids, i.e., derivatives of the anthranilica acid, these electrets are polypeptides and provide a means to employ principles of proteomics in their design and development. Rational functionalization of the non-native residues allows for accessing a wide range of electronic properties, as reveled by varying their reduction potentials. Development of such non-native redox-active non-native amino acids sets the foundation for introducing synthetic proteome to the field of charge transfer.
Erratum to: A linear classifier based on entity recognition tools and a statistical approach to method extraction in the protein-protein interaction literature (2012)

Abstract Correction to A. Lourenço, M. Conover, A. Wong, A. Nematzadeh, F. Pan, H. Shatkay, and L.M. Rocha."A Linear Classifier Based on Entity Recognition Tools and a Statistical Approach to Method Extraction in the Protein-Protein Interaction Literature". BMC Bioinformatics 2011, 12(Suppl 8):S12. doi: http://10.1186/1471-2105-12-S8-S12 .
Realized Access to Physician Services Among the Elderly in West Texas (2003)

The purpose of this study is to identify populations in a sparsely populated region that are less likely to obtain medical care. We conducted a cross-sectional survey of more than 5,000 elderly persons who participated in telephone interviews after being identified through more than 65,000 calls to residential listings. Subjects were persons aged 65 years and older who resided in 108 counties in western Texas. The response rate was 72%. The probability of seeing a physician in the last 6 months for urban and rural residents was modeled using multiple logistic regression analysis. Among rural residents, characteristics that were significantly (p < 0.05) associated with not recently visiting a physician when health status is held constant included belief in home remedies, having less than a high school education, lack of health insurance, and low income. Among urban residents, Hispanic ethnicity and skepticism about medical care were negatively associated with having a recent visit, whereas being religious was positively associated. Despite the availability of Medicare coverage, several subgroups of the elderly population have impaired access to medical care in this sparsely populated region. Intensified outreach efforts are indicated.
Channel and contact length scaling in carbon nanotube transistors (2010)

In summary, results are presented on the effects of L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">g</sub> and CL scaling in CNTFETs. To consider CNTFETs for a high performance technology, any limitations related to their aggressive scaling must be understood. Devices with excellent and reproducible performance were fabricated with L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">g</sub> and CL as small as 15 and 20 nm, respectively-projected achievable pitch of 45 nm, which would be suitable beyond the 8 nm technology node. In fact, the smallest CNTFET to date is demonstrated having CL ≈ L <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">g</sub> ≈ 20 nm with superb performance.
Weighted LabPQR Interim Connection Space Based on Human Color Vision for Spectral Color Reproduction (2014)

A weighted LabPQR interim connection space, based on human color vision, is proposed for retaining more visual color information. A new weight function proposed in our paper is connected with color-matching function and then further weighted the PQR dimensions of LabPQR compared with the other two weight functions and nonweight function. The results indicated that weighting obviously improved the colorimetric representing accuracy and robustness compared with nonweighting, and the new weight function outperformed the other two weight functions. The weighted LabPQR of the new weight function is most suitable for spectral color reproduction.
Design, implementation and commissioning of a fuzzy-adaptive mould level control system (1999)

In this paper, a new fuzzy-adaptive mould level control to improve the steel guality in the continuous casting process will be described. The concept does not reguired additional hardware. The presented commissioning results show a better control behaviour e.g. in case of worn stoppers.
Regulation of Integrin Activity by MIA (2006)

MIA (melanoma inhibitory activity) has been identified as a small protein secreted from malignant melanoma cells, which interacts with extracellular matrix proteins including fibronectin. Here, we show that MIA negatively regulates the activity of the mitogen-activated protein kinase pathway in malignant melanoma. Using far Western blotting and co-immunoprecipitation we searched for MIA-binding cell surface proteins. We found that MIA interacts with integrin alpha4beta1 and alpha5beta1, leading to down-regulation of integrin activity and reduction of mitogen-activated protein kinase signaling. These findings also suggest that MIA may play a role in tumor progression and the spread of malignant melanomas via mediating detachment of cells from extracellular matrix molecules by modulating integrin activity. Inhibiting MIA functions in vivo may therefore provide a novel therapeutic strategy for metastatic melanoma disease.