gebhart/patrepeval huggingface dataset:
Evolution, biogenesis and function of promoter-associated RNAs (2009)

Transcription initiation is a tightly controlled process that involves chromatin modifications and nucleosome remodelling, transcription factor binding, and the assembly and recruitment of the RNA Polymerase II (RNAPII) complex. Recent studies have reported a diversity of long and short RNAs derived from eukaryotic promoters, which may be involved in transcription regulation. Here we review these species with particular attention to the features and biogenesis of transcription initiation RNAs (tiRNAs), a class of 18 nucleotide small RNA conserved from insects to mammals. We also report and discuss the observation that tiRNAs are not present in plants and are not clearly expressed in the nematode C. elegans. We suggest that tiRNAs may be intimately connected RNAPII backtracking, nucleosome marking, and gene regulation.
Transformation of computerized electrocardiogram data into novel means to differentiate wide complex tachycardias (2022)

Abstract Background Accurate automated wide QRS complex tachycardia (WCT) discrimination between ventricular tachycardia (VT) and supraventricular wide complex tachycardia (SWCT) can be accomplished using novel calculations derived from computerized electrocardiogram (ECG) data from paired WCT and baseline ECGs. Purpose Our aim was to develop and trial novel WCT discrimination approaches for WCT patients with and without a corresponding baseline ECG. Central to this analysis was the creation and use of a novel parameter (i.e., percent monophasic time-voltage area [PMonoTVA] [%]) that may be derived from computerized ECG measurements present on the WCT ECG alone. Methods In a two-part study, we derived and tested WCT differentiation models comprised of novel and previously established parameters formulated from computerized data of paired WCT and baseline ECGs. In Part 1, novel and established parameters generated from WCT and baseline ECG data were used to derive, validate, and compare five different binary classification models: (i) logistic regression [LR], (ii) artificial neural network [ANN], (iii) Random Forests [RF], (iv) support vector machine [SVM], and (v) ensemble learning (EL). In Part 2, two unique LR models were derived, validated, and compared using parameters generated from computerized data of the (i) WCT ECG alone (i.e., Solo Model) and (ii) paired WCT and baseline ECGs (i.e., Paired Model). Results In Part 1, among 103 patients with VT or SWCT diagnoses established from corroborating electrophysiology studies or intra-cardiac device recordings, favorable diagnostic performance was achieved by all modeling technique subtypes: LR (area under the receiver operating characteristic curve [AUC] 0.95), ANN (AUC 0.91), RF (AUC 0.97), SVM (AUC 0.98), and EL (AUC 0.97). In Part 2, among 235 patients with a VT or SWCT diagnosis established with (Gold Standard cohort) or without (Non-Gold Standard cohort) a corroborating electrophysiology procedure or intra-cardiac device recording, favorable diagnostic performance was achieved by the Solo Model (AUC 0.86) and Paired Model (AUC 0.95) (Table). Conclusion Accurate WCT discrimination may be accomplished using novel parameters derived from computerized data of the WCT ECG alone and paired WCT and baseline ECGs. Funding Acknowledgement Type of funding sources: Public grant(s) – National budget only. Main funding source(s): National Institute of Health
Promoting developer-specific awareness (2008)

Maintaining a developer's awareness of changes in the software on which she depends is challenging. Awareness is often impeded at two ends of the spectrum: a lack of information, when the changes only become apparent when a build breaks or bugs appear; or an excess of information, where the changes are announced but the majority of the changes are not relevant to the developer in her particular project and context. In the middle ground lies the possibility of support for developer-specific awareness (DSA), wherein information about the changes is filtered on the basis of the developer's own code and interests. This paper discusses how the DSA problem is manifested in software development and briefly examines the design space involved in providing DSA notifications. A particular point in the space is proposed for a target implementation, called the YooHoo awareness system, that will help developers in loose organizations to keep apprised of any code changes that are specifically relevant to the source code for which they are responsible.
Revolutionary Love (2019)

From social theorist and psychotherapist Rabbi Michael Lerner comes a strategy for a new socialism built on love, kindness, and compassion for one another. Revolutionary Love proposes a method to replace what Lerner terms the "capitalist globalization of selfishness" with a globalization of generosity, prophetic empathy, and environmental sanity. Lerner challenges liberal and progressive forces to move beyond often weak-kneed and visionless politics to build instead a movement that can reverse the environmental destructiveness and social injustice caused by the relentless pursuit of economic growth and profits. Revisiting the hidden injuries of class, Lerner shows that much of the suffering in our society—including most of its addictions and the growing embrace of right-wing nationalism and reactionary versions of fundamentalism—is driven by frustrated needs for community, love, respect, and connection to a higher purpose in life. Yet these needs are too often missing from liberal discourse. No matter that progressive programs are smartly constructed—they cannot be achieved unless they speak to the heart and address the pain so many people experience. Liberals and progressives need coherent alternatives to capitalism, but previous visions of socialism do not address the yearning for anything beyond material benefits. Inspired by Herbert Marcuse, Erich Fromm, and Carol Gilligan, Revolutionary Love offers a strategy to create the "Caring Society." Lerner details how a civilization infused with love could put an end to global poverty, homelessness, and hunger, while democratizing the economy, shifting to a twenty-eight-hour work week, and saving the life-support system of Earth. He asks that we develop the courage to stop listening to those who tell us that fundamental social transformation is "unrealistic."
Temperature control and thermal dosimetry by microwave radiometry in hyperthermia (1996)

Presents a synthesis of works undertaken by the Hyperthermia Group of Lille (France) concerning the utilization of microwave radiometry for temperature control in hyperthermia therapy. This technique of noninvasive temperature control within biological tissues has been integrated on many hyperthermia systems now commercialized. The authors describe the principle of a new radiometer as well as the calculation of the radiometric signals. This allows a noninvasive determination of thermal maps inside tissues during the hyperthermia treatments. Many comparisons between theory and experiment have validated the authors' models of thermal dosimetry and provide a quantitative guidance for the planning of hyperthermia treatments.
Variations of pre-proNPY mRNA in the arcuate nucleus during the rat estrous cycle (1992)

In order to assess the role of sex steroids on the regulation of neuropeptide Y (NPY), levels of pre-proNPY mRNA were measured by in situ hybridization in the rat arcuate nucleus during the estrous cycle. Pre-proNPY mRNA levels were quite stable during diestrus I, diestrus II and the morning of the proestrus, and were 25-30% higher during the afternoon of the proestrus and during the day of the estrus. These data suggest that NPY synthesis is modulated by variations in the circulating levels of sex steroids. Also the excellent correlation between the variations in the levels of pre-proNPY mRNA and those of luteinizing hormone-releasing hormone (LHRH) mRNA observed throughout the estrous cycle supports the hypothesis that NPY might be involved in the regulation of LHRH secretion.
The dual role of Fas-ligand as an injury effector and defense strategy in diabetes and islet transplantation (2006)

The exact process that leads to the eruption of autoimmune reactions against beta cells and the evolution of diabetes is not fully understood. Macrophages and T cells may launch an initial immune reaction against the pancreatic islets of Langerhans, provoking inflammation and destructive insulitis. The information on the molecular mechanisms of the emergence of beta cell injury is controversial and points to possibly important roles for the perforin-granzyme, Fas-Fas-ligand (FasL) and tumor-necrosis-factor-mediated apoptotic pathways. FasL has several unique features that make it a potentially ideal immunomodulatory tool. Most important, FasL is selectively toxic to cytotoxic T cells and less harmful to regulatory T cells. This review discusses the intrinsic sensitivity of beta cells to FasL-mediated apoptosis, the conditions that underlie this beta cell sensitivity, and the feasibility of using FasL to arrest autoimmunity and prevent islet allograft rejection. In both the autoimmune and transplant settings, it is imperative to progress from the administration of nonspecific immunosuppressive therapy to the concept of beta-cell-specific immunomodulation. FasL evolves as a prime candidate for antigen-specific immunomodulation.
The antiradical activity of some plant raw materials and extracts obtained from these raw materials. (2012)

The strongest antiradical activity was noted for extracts obtained from Cinnamomi cortex; the number of antiradical units per mg of extract (TAU(515/mg)) was 10.31±1.052. The lowest antiradical features were exhibited by extract from Zingiberis rhizoma (0.28±0.174) and extract from Cichorii radix (0.38±0.669). The highest amount of phenolic compounds was measured for extracts from Bistortae rhizoma, with a value (in percentage) of 78.6±13.5. The correlation coefficient between the number of antiradical units in extracts and amount of phenolic compounds in these extracts was 0.7273. When the number of antiradical units was calculated per g of raw material (TAU(515/g)) the strongest antiradical properties were noted for Bistortae rhizoma (1406±274.9), the weakest for Cichorii radix (122±158.3).
Development of downward compact conical-ended borehole overcoring technique for rock stress measurement (2020)

In order to determine complete in-situ stress at great depth with high accuracy, down ward compact conical-ended borehole overcoring (DCCBO) technique, which is one of stress relief methods, was developed. DCCBO technique can be applied to a water-filled vertical borehole. In a shallow in-situ test, a measuring system consisting of a bonding device, a cleaning system and a multi-channel data logger were verified to work well in a water-filled borehole with cuttings on the bottom. Thus, we confirmed the usability of DCCBO technique.
From Hidden Shear-Elasticity to Opto-and Thermo-Elastic properties in Confined Polymer Melts and Viscous Liquids (2021)

International audience
IMPACT ON OBSERVED RAINFALL AND PATTERNS OF SEA SURFACE TEMPERATURE ON FLOOD ANALYSIS USING MASSIVE CLIMATE PREDICTION DATA (2019)

大規模気候予測情報に基づく適切な浸水リスク推計に向け，雄物川流域を対象として，バイアス補正に用いる観測値の選択および将来海面水温パターンが浸水リスク推計に及ぼす影響を調査した．観測値の選択に関しては，観測期間が異なる2つの観測値を基にバイアス補正を行い，その観測値の差異が洪水氾濫シミュレーション結果に及ぼす影響を推計した．その結果，観測期間の短い観測値を用いた場合には洪水氾濫シミュレーション結果による結果の極端な値が過小評価される傾向が示された．さらに，大規模気候予測情報が有する複数の将来海面水温パターンが洪水氾濫シミュレーション結果に及ぼす影響を推計した．その結果，浸水リスク推計結果は海面水温パターンで明確に異なることが示された．
Functional Repair of Human Donor Lungs by IL-10 Gene Therapy (2009)

More than 80% of potential donor lungs are injured during brain death of the donor and from complications experienced in the intensive care unit, and therefore cannot be used for transplantation. These lungs show inflammation and disruption of the alveolar-capillary barrier, leading to poor gas exchange. Although the number of patients in need of lung transplantation is increasing, the number of donors is static. We investigated the potential to use gene therapy with an adenoviral vector encoding human interleukin-10 (AdhIL-10) to repair injured donor lungs ex vivo before transplantation. IL-10 is an anti-inflammatory cytokine that mainly exerts its suppressive functions by the inactivation of antigen-presenting cells with consequent inhibition of proinflammatory cytokine secretion. In pigs, AdhIL-10-treated lungs exhibited attenuated inflammation and improved function after transplantation. Lungs from 10 human multiorgan donors that had suffered brain death were determined to be clinically unsuitable for transplantation. They were then maintained for 12 hours at body temperature in an ex vivo lung perfusion system with or without intra-airway delivery of AdhIL-10 gene therapy. AdhIL-10-treated lungs showed significant improvement in function (arterial oxygen pressure and pulmonary vascular resistance) when compared to controls, a favorable shift from proinflammatory to anti-inflammatory cytokine expression, and recovery of alveolar-blood barrier integrity. Thus, treatment of injured human donor lungs with the cytokine IL-10 can improve lung function, potentially rendering injured lungs suitable for transplantation into patients.
The Effects of Choline Supplementation on Physical Performance (2000)

It has been reported that plasma choline levels decrease following certain types of strenuous exercise. Preliminary findings also suggest that a drop in plasma choline may limit physical performance, while choline supplementation may delay fatigue during prolonged efforts. A double-blind crossover design was used to determine the relationship between plasma choline and performance during and after 4 hr of strenuous exercise. Volunteers (N = 14) received either a placebo or treatment beverage (8.425 g choline citrate) prior to and midway through a 4-hr load carriage treadmill exercise (3% grade at 5.6 km/h 3 20 km) carrying a total load of 34.1 kg. Following the treadmill test, run time-to-exhaustion and squat tests were performed, and perceived exertion, plasma choline, glycerophosphocholine, and phosphatidylcholine were measured. Plasma choline levels increased 128% after the run-to-exhaustion with the choline supplemented beverage but remained unchanged with the placebo beverage. No significant effects were seen with choline supplementation on any outcome performance measure. Consequently, soldiers conditioned to carry heavy loads over long distances do not deplete plasma choline as a result of a prolonged exhaustive exercise under a placebo beverage, nor do they benefit from choline supplementation to delay fatigue under the same conditions.
The integration of data reduction and structure solution - from diffraction images to an initial model in minutes (2005)

the pipeline running on a Linux cluster at UGA via the web. The average total time for data collection and structure determination was 191 minutes. The structures solved represented an average mix of structural genomics targets with molecular weights ranging from 12 -25 kDa.
Hexameric trimethylsilylmethyloxotin acetate, [(Me3SiCH2)Sn(O)(OAc)]6 (2004)

The centrosymmetric hexanuclear title compound, hexa-μ2-acetato-hexa-μ3-oxo-hexakis­[(tri­methyl­silyl­methyl)­tin], [Sn6O6(C2H3O2)6(C4H11Si)6], adopts a `drum' structure in which two [(Me3SiCH2)SnO]3 caps are linked to each other via six μ3-O atoms and six bidentate bridging acetate groups. A CO5 donor set defines a distorted octahedral environment for each of the three independent Sn atoms.
Practical Application Of Thermal Error Correction- 4 Case Studies (1970)

Thermal distortion of machine tool structures is widely recognised as a significant cause of component inaccuracy within modern CNC machining. It is difficult to develop a practical single compensation strategy which can deal with the different aspects of machine tool thermal behaviour. Systems which attempt to do this are usually complex and time consuming to implement. The approach adopted here is to devise a range of relatively simple error tracking techniques, and a formalised philosophy for determining which technique is appropriate in each case. The different techniques are illustrated by 4 case studies, and the application and effectiveness of each approach is discussed.
ChemInform Abstract: ZINC(II), IRON(III), MOLYBDENUM(II) CHLORIDE AND MOLYBDENUM(V), MOLYBDENUM(VI) OXOCHLORIDE COMPLEXES OF TRIMETHYLAMINE: SYNTHESIS, SPECTRA AND X‐RAY CRYSTAL STRUCTURE CHARACTERIZATION (1985)

Abstract Die Umsetzung von überschüssigem Trimethylamin mit ZnCl 2 , FeCl 3 , MoCl 3 , MoOCl 4 oder MoOCl 3 ergibt zum Teil unter Reduktion die Komplexe (I)‐(V).
Sodiation Kinetics of Metal Oxide Conversion Electrodes: A Comparative Study with Lithiation (2016)

The development of sodium ion batteries (NIBs) can provide an alternative solution to lithium ion batteries (LIBs) for sustainable, low-cost energy storage. Due to the many similarities between sodium and lithium chemistries, the development of sodium-ion batteries (NIBs) – in particular the discovery and development of electrode materials – has been benefited greatly from the knowledge developed in understanding lithium chemistries in LIBs. However, many electrode materials used in LIBs show an inferior performance in sodiation. For example, in transition metal oxides MO x (M = Fe, Co and Ni), the sodiation reactions have shown much lower capacity and slower kinetics than those commonly observed in lithiation reactions. This could not be simply interpreted from the difference in the ionic size of Na + and Li + because the reaction happened in this system is not intercalation but conversion. For the conversion compounds, although there were many papers published to investigate their electrochemical performance, the origin of different reaction kinetics is still not clear which hinder the further study on this system. To address this issue, we present herein our comprehensive, systematic study of the sodiation and lithiation of a model MO x conversion compound, viz., nanostructured sheets of NiO. We investigate the sodiation and lithiation processes using a combination of multiple temporal- and spatial-scaled characterization techniques, including electrochemical measurements, in situ transmission electron microscopy (TEM), and ab initio molecular dynamics (MD) simulations. From the in situ TEM, where our previous results showing the lithiation heterogeneous reaction pathways, we found the sodiation only go through a “shrinking-core” pathway and further sodiation was blocked by a crystalline passivation layer of Na 2 O that formed at an early stage. Our MD simulation shows that the sodiation pathway originates from a layer-by-layer reaction that occurs during the insertion of Na ions; this was the rate-determining step for the entire process. In case of lithiation, however, the formation of Li anti-site defects significantly distorts the local NiO lattice, which thereby facilitates Li insertion and enhance the overall reaction rate. In conclusion, the intrinsic layer-by-layer sodiation reaction and the formation of a crystalline passivation layer of Na 2 O play an important role for sluggish sodiation reactions.
Polymeric (η5,μ‐2,3‐Dihydro‐1,3‐diborolyl)nickel—the First Polydecker Sandwich Compound (1986)

An old idea in sandwich chemistry has now been realized: The black, film-like polymer 2 was obtained by thermal polycondensation of the dinickel complex 1 in vacuo. The thermally very stable but oxygen-sensitive 2 is a semiconductor. EXAFS investigations suggest a distorted polydecker sandwich structure.
Dendrimer‐Triamcinolone Acetonide Reduces Neuroinflammation, Pathological Angiogenesis, and Neuroretinal Dysfunction in Ischemic Retinopathy (2020)

Diabetic retinopathy (DR) is the leading cause of blindness in working-age adults. Severe visual loss in DR is primarily due to proliferative diabetic retinopathy, characterized by pathologic preretinal angiogenesis driven by retinal ischemia. Microglia, the resident immune cells of the retina, have emerged as a potentially important regulator of pathologic retinal angiogenesis. Corticosteroids including triamcinolone acetonide (TA), known for their antiangiogenic effects, are used in treating retinal diseases, but their use is significantly limited by side effects including cataracts and glaucoma. Generation-4 hydroxyl polyamidoamine dendrimer nanoparticles are utilized to deliver TA to activated microglia in the ischemic retina in a mouse model of oxygen-induced retinopathy (OIR). Following intravitreal injection, dendrimer-conjugated TA (D-TA) exhibits selective localization and sustained retention in activated microglia in disease-associated areas of the retina. D-TA, but not free TA, suppresses inflammatory cytokine production, microglial activation, and preretinal neovascularization in OIR. In addition, D-TA, but not free TA, ameliorates OIR-induced neuroretinal and visual dysfunction. These results indicate that activated microglia are a promising therapeutic target for retinal angiogenesis and neuroprotection in ischemic retinal diseases. Furthermore, dendrimer-based targeted therapy and specifically D-TA constitute a promising treatment approach for DR, offering increased and sustained drug efficacy with reduced side effects.
Practical Fault Attack on Deep Neural Networks (2018)

As deep learning systems are widely adopted in safety- and security-critical applications, such as autonomous vehicles, banking systems, etc., malicious faults and attacks become a tremendous concern, which potentially could lead to catastrophic consequences. In this paper, we initiate the first study of leveraging physical fault injection attacks on Deep Neural Networks (DNNs), by using laser injection technique on embedded systems. In particular, our exploratory study targets four widely used activation functions in DNNs development, that are the general main building block of DNNs that creates non-linear behaviors -- ReLu, softmax, sigmoid, and tanh. Our results show that by targeting these functions, it is possible to achieve a misclassification by injecting faults into the hidden layer of the network. Such result can have practical implications for real-world applications, where faults can be introduced by simpler means (such as altering the supply voltage).
Velocity Determination of Particles Ejected During Electron Beam Deposition (2013)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text J. E. Wolfe, C. J. Stolz, and S. Falabella, "Velocity Determination of Particles Ejected During Electron Beam Deposition," in Optical Interference Coatings, M. Tilsch and D. Ristau, eds., OSA Technical Digest (online) (Optica Publishing Group, 2013), paper FA.2. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article