gebhart/patrepeval huggingface dataset:
Transcriptional regulation of human polyomavirus JC: evidence for a functional interaction between RelA (p65) and the Y-box-binding protein, YB-1 (1996)

The transcriptional control region of the human neurotropic polyomavirus JC virus contains a consensus NF-kappa B site which has been shown to enhance both basal and extracellular stimulus-induced levels of transcription of JC promoters. Here, we show that the expression of JC late promoter constructs containing the NF-kappa B site is decreased by cotransfection with the NF-kappa B/rel subunits, p50 and p52, but enhanced by the p65 subunit. However, JC promoter constructs lacking the NF-kappa B site were activated by p52 and p50 and repressed by p65. This antithetical response of the JC promoter mapped specifically to the D domain, which is a target site for the cellular transcription factor, YB-1. Band shift studies indicated that YB-1 and p65 modulate each other's binding to DNA: YB-1 augments the affinity of p65 for the NF-kappa B site, while p65 reduces the binding of YB-1 to the D domain. Results from coimmunoprecipitation followed by Western blot (immunoblot) analysis suggest an in vivo interaction between p65 and YB-1 in glial cells. Functionally, YB-1 appears to act synergistically with p65 to control transcription from the NF-kappa B site. A converse pattern is seen with the D domain, in which YB-1 acts synergistically with p50 and p52 to regulate transcription. p50 and p52 may function as transcriptional activators on the D domain by removing the repressive effect of p65 on YB-1 binding to the D domain. On the basis of these data, we propose a model in which NF-kappa B/rel subunits functionally interact with consensus NF-kappa B sites or YB-1-binding sites, with disparate effects on eukaryotic gene expression.
Stability of Metal Chalcogenide Nanotubes (2002)

An overview about the characteristic structure of metal chalcogenide nanotubes is given in this paper. On the basis of atomistic calculations, parameters for a model are derived, describing the stability of tubular structures. Especially the interplay between the strain energy in the tubes and the energy due to unsaturated (dangling) bonds in layer stripes and the role of the van der Waals interaction in multilayer stripes and tubes are discussed. In agreement with experimental observations it is shown that nanotubes with a diameter larger than about 6 nm are more stable than stripes of a corresponding width. The van der Waals interaction stabilizes multilayered stripes, leads to multiwalled nanotubes, and can explain the nonexistence of single-wall metal chalcogenide nanotubes.
The effect of changing foot progression angle using real-time visual feedback on rearfoot eversion during running (2021)

Atypical rearfoot in/eversion may be an important risk factor for running-related injuries. Prominent interventions for atypical rearfoot eversion include foot orthoses, footwear, and taping but a modification derived from gait retraining to correct atypical rearfoot in/eversion is lacking. We aimed to investigate changes in rearfoot in/eversion, subtalar pronation, medial longitudinal arch angle, and selected lower limb joint biomechanics while performing toe-in/toe-out running using real-time visual feedback. Fifteen female runners participated in this study. Subjects performed toe-in/toe-out running using real-time visual feedback on foot progression angle, which was set ±5° from habitual foot progression angle. 3D kinematics of rearfoot in/eversion, subtalar supination/pronation, medial longitudinal arch angle, foot progression angle, hip flexion, ab/adduction and internal/external rotation, knee flexion, ankle dorsiflexion, and ankle power were analyzed. A repeated-measures ANOVA followed by pairwise comparisons was used to analyze changes between three conditions. Toe-in running compared to normal and toe-out running reduced peak rearfoot eversion (mean difference (MD) with normal = 2.1°; p<0.001, MD with toe-out = 3.5°; p<0.001), peak pronation (MD with normal = -2.0°; p<0.001, MD with toe-out = -3.4; p = <0.001), and peak medial longitudinal arch angle (MD with normal = -0.7°; p = 0.022, MD with toe-out = -0.9; p = 0.005). Toe-out running significantly increased these kinematic factors compared to normal and toe-in running. Toe-in running compared to normal running increased peak hip internal rotation (MD = 2.3; p<0.001), and reduced peak knee flexion (MD = 1.3; p = 0.014). Toe-out running compared to normal running reduced peak hip internal rotation (MD = 2.5; p<0.001), peak hip ab/adduction (MD = 2.5; p<0.001), peak knee flexion (MD = 1.5; p = 0.003), peak ankle dorsiflexion (MD = 1.6; p<0.001), and peak ankle power (MD = 1.3; p = 0.001). Runners were able to change their foot progression angle when receiving real-time visual feedback for foot progression angle. Toe-in/toe-out running altered rearfoot kinematics and medial longitudinal arch angle, therefore supporting the potential value of gait retraining focused on foot progression angle using real-time visual feedback when atypical rearfoot in/eversion needs to be modified. It should be considered that changes in foot progression angle when running is accompanied by changes in lower limb joint biomechanics.
Impact of a preoperative conversational hypnotic session on propofol consumption using closed-loop anesthetic induction guided by the bispectral index (2017)

No difference in propofol consumption was observed in this study designed to evaluate the effect of a hypnotic conversational session on anesthesia induction using an automated tool for propofol administration.
The 'Tapada da Ajuda,' Portugal's First Botanical Garden (1987)

(Uploaded by Plazi from the Biodiversity Heritage Library) No abstract provided.
New Nanocrystalline Core Performance Versus Finemet(Registered) for High-power Inductors (2008)

Abstract : Advanced power electronic component development is critical for increasing power density for future military hybrid-electric ground vehicle systems. The design and development of compact, high-power, and high-temperature inductors for a 150 kW, DC-DC bidirectional converter is presented. The converter requires four 25 micronH inductors, each rated for continuous operation at 37.5 kW. With goals of reduced component volume and improved thermal management, inductor performance for commercially available FINEMET(Registered) FT-3M and newly developed HTX-002 nanocrystalline core material is compared.
UHP lamp systems for projection applications (2005)

Projection systems have found widespread use in conference rooms and other professional applications during the last decade and are now entering the home TV market at a considerable pace. Projectors as small as about one litre are able to deliver several thousand screen lumens and are, with a system efficacy of over 10 lm W−1, the most efficient display systems realized today. Short arc lamps are a key component for projection systems of the highest efficiency for small-size projection displays.
Small Molecule Lysyl Oxidase-like 2 (LOXL2) Inhibitors: The Identification of an Inhibitor Selective for LOXL2 over LOX (2017)

Two series of novel LOXL2 enzyme inhibitors are described: benzylamines substituted with electron withdrawing groups at the <i>para</i>-position and 2-substituted pyridine-4-ylmethanamines. The most potent compound, (2-chloropyridin-4-yl)methanamine <b>20</b> (hLOXL2 IC<sub>50</sub> = 126 nM), was shown to be selective for LOXL2 over LOX and three other amine oxidases (MAO-A, MAO-B, and SSAO). Compound <b>20</b> is the first published small molecule inhibitor selective for LOXL2 over LOX.
VISCOSITY STUDIES OF SYSTEM CaO‐MgO‐Al 2 O 3 ‐SiO 2: II, CaO‐Al 2 O 3 ‐SiO 2 * (1948)

A bstract Viscosity data are presented covering those compositions in the CaO‐Al 2 O 3 ‐SiO 2 system which are liquid at 1500°C. The pattern of isokoms on the CaO‐Al 2 O 3 ‐SiO 2 face of the compositional tetrahedron which represents the CaO‐MgO‐Al 2 O 3 ‐SiO 2 system is a system of lines which roughly parallel the lines along which the lime content is constant. There are, however, considerable deviations from this parallelism in regions of very low and very high alumina content.
CREB3 subfamily transcription factors are not created equal: Recent insights from global analyses and animal models (2011)

Abstract The CREB3 subfamily of membrane-bound bZIP transcription factors has five members in mammals known as CREB3 and CREB3L1-L4. One current model suggests that CREB3 subfamily transcription factors are similar to ATF6 in regulated intramembrane proteolysis and transcriptional activation. Particularly, they were all thought to be proteolytically activated in response to endoplasmic reticulum (ER) stress to stimulate genes that are involved in unfolded protein response (UPR). Although the physiological inducers of their proteolytic activation remain to be identified, recent findings from microarray analyses, RNAi screens and gene knockouts not only demonstrated their critical roles in regulating development, metabolism, secretion, survival and tumorigenesis, but also revealed cell type-specific patterns in the activation of their target genes. Members of the CREB3 subfamily show differential activity despite their structural similarity. The spectrum of their biological function expands beyond ER stress and UPR. Further analyses are required to elucidate the mechanism of their proteolytic activation and the molecular basis of their target recognition.
The paradox of response and survival in cancer therapeutics (2005)

Although most patients with cancer respond to therapy, few are cured. Moreover, objective clinical responses to treatment often do not even translate into substantial improvements in overall survival. For example, patients with indolent lymphoma who achieved a complete remission with conventional-dose therapies in the prerituximab era did not experience a survival advantage over similar patients treated with a "watch and wait" approach. Several studies have also shown that neither the magnitude nor the kinetics of clinical response has an impact on survival in multiple myeloma. Recent data suggesting many malignancies arise from a rare population of cells that exclusively maintains the ability to self-renew and sustains the tumor (ie, "cancer stem cells") may help explain this paradox that response and survival are not always linked. Therapies that successfully eliminate the differentiated cancer cells characterizing the tumor may be ineffective against rare, biologically distinct cancer stem cells. New methods for assessing treatment efficacy must also be developed, as traditional response criteria measure tumor bulk and may not reflect changes in rare cancer stem cell populations. In this article, we discuss the evidence for cancer stem cells in hematologic malignancies and possible ways to begin targeting these cells and measuring clinical effectiveness of such treatment approaches.
Macular Bruch's membrane defects in Hi (2014)

Abstract Purpose To examine prevalence and associations of macular Bruch's membrane defects (MBMDs) in a population‐based setting. Methods The Beijing Eye Study 2011 included 3468 subjects with an age of 50+ years. MBMDs were defined as an interruption of Bruch´s membrane on the OCT images in the macular region. Results MBMDs could be detected only in highly myopic eyes (≤‐6 diopters or axial length of ≥26.5 mm). Prevalence of MBMDs in the highly myopic group was 17/164 (10.4±2.4%). Mean axial length of eyes with MBMD was 29.6±0.3 mm. Best corrected visual acuity of &lt;0.05 was found in 5 (29%) out of 17 eyes with MBMDs, and in 7 (41%) eyes, visual acuity was &lt;0.3 and ≥0.05. In the MBMD region, RPE and choriocapillaris were completely lost, and the deep and middle layers of the retina and the choroid were almost completely absent. In the MBMD region, mean retinal thickness was 153±57μm (range 20‐234μm) and choroidal thickness was 12.7±28.1μm (range 0‐88μm). On the fundus photographs, MBMDs appeared as whitish areas with round borders and without signs of RPE and choroid except of large choroidal vessels. In multivariate regression analysis, presence of MBMD was significantly associated only with longer axial length (P=0.002; Odds ratio: 3.87; 95% confidence interval: 1.64, 9.14). Conclusion MBMDs with a prevalence of about 10% in highly myopic eyes are associated with a complete loss of RPE and choriocapillaris, an almost complete loss of photoreceptors and choroid, and marked reduction in visual acuity. Characterized by a whitish fundus lesion with round borders, MBMDs can be differentiated from a chorioretinal atrophic lesion with Bruch´s membrane present. MBMDs may be added to the panoply of features of myopic maculopathy.
Human Islet Amyloid Polypeptide Gene: Complete Nucleotide Sequence, Chromosomal Localization, and Evolutionary History (1989)

The gene-encoding human islet amyloid polypeptide (hIAPP), a recently discovered 37 amino acid hormone-like polypeptide which is expressed in the insulin-producing beta-cells of the endocrine pancreas, has been isolated and characterized. The coding region of the gene is interrupted in the 5'-untranslated region and NH2-terminal propeptide by introns of 330 and 4808 base pairs (bp), respectively. Exon 1 (104 bp) encodes most of the 5'-untranslated region of the mRNA; exon 2 (95 bp) encodes 15 nucleotides of 5'-untranslated region, the putative 22 amino acid signal peptide and five residues of the NH2-terminal propeptide; exon 3 (1246 bp) encodes the remainder of the NH2-terminal propeptide (residues 6-9), the IAPP moiety and its processing signals and the 16 amino acid COOH-terminal propeptide, as well as the 3'-untranslated region of the mRNA (1059 bp). Analysis of the nucleotide and predicted amino acid sequence of intron 2 of the hIAPP gene did not reveal any homology with the structurally related calcitonin/calcitonin-gene-related peptide genes and indicated that, in contrast to these latter genes, the hIAPP gene apparently gives rise to only a single hormonal product. The transcriptional initiation site was identified about 28 bp downstream from a TATAA sequence. The hIAPP gene was localized to the p12.3 region of chromosome 12.
Glaucoma diagnosis by mapping macula with Fourier domain optical coherence tomography (2008)

A new image segmentation method was developed to detect macular retinal sub-layers boundary on newly-developed Fourier-Domain Optical Coherence Tomography (FD-OCT) with macular grid scan pattern. The segmentation results were used to create thickness map of macular ganglion cell complex (GCC), which contains the ganglion cell dendrites, cell bodies and axons. Overall average and several pattern analysis parameters were defined on the GCC thickness map and compared for the diagnosis of glaucoma. Intraclass correlation (ICC) is used to compare the reproducibility of the parameters. Area under receiving operative characteristic curve (AROC) was calculated to compare the diagnostic power. The result is also compared to the output of clinical time-domain OCT (TD-OCT). We found that GCC based parameters had good repeatability and comparable diagnostic power with circumpapillary nerve fiber layer (cpNFL) thickness. Parameters based on pattern analysis can increase the diagnostic power of GCC macular mapping.
Supporting Software Architecture Maintenance by Providing Task-Specific Recommendations (2019)

During software maintenance, developers have different information needs (e.g., to understand what type of maintenance activity to perform, the impact of a maintenance activity and its effort). However, information to support developers may be distributed across various sources. Furthermore, information captured in formal architecture documentation may be outdated. In this paper, we put forward a late breaking idea and outline a solution to improve the productivity of developers by providing task-specific recommendations based on concrete information needs that arise during software maintenance.
Lingering prenatal effects of the 1918 influenza pandemic on cardiovascular disease (2009)

Prenatal exposure to the 1918 influenza pandemic (Influenza A, H1N1 subtype) is associated with ⩾20% excess cardiovascular disease at 60 to 82 years of age, relative to cohorts born without exposure to the influenza epidemic, either prenatally or postnatally (defined by the quarter of birth), in the 1982-1996 National Health Interview Surveys of the USA. Males showed stronger effects of influenza on increased later heart disease than females. Adult height at World War II enlistment was lower for the 1919 birth cohort than for those born in adjacent years, suggesting growth retardation. Calculations on the prevalence of maternal infections indicate that prenatal exposure to even uncomplicated maternal influenza may have lasting consequences later in life. These findings suggest novel roles for maternal infections in the fetal programming of cardiovascular risk factors that are independent of maternal malnutrition.
Comparison of Orbiter STS-2 development flight instrumentation data with thermal math model predictions (1982)

Thermal performance verification of Reusable Surface Insulation (RSI) has been accomplished by comparisons of STS-2 Orbiter Flight Test (OFT) data with Thermal Math Model (TMM) predictions. The OFT data was obtained from Development Flight Instrumentation RSI plug and gap thermocouples. Quartertile RSI TMMs were developed using measured flight data for surface temperature and pressure environments. Reference surface heating rates, derived from surface temperature data, were multiplied by gap heating ratios to obtain tile sidewall heating rates. This TMM analysis resulted in good agreement of predicted temperatures with flight data for thermocouples located in the RSI, Strain Isolation Pad, filler bar and structure.
Components of vitreous-soluble proteins: effect of hyperoxia and age. (1976)

In young puppies, the retina, which is incompletely vascularized at birth becomes fully vascularized at approximately four weeks of age. During this period of vessel growth the total content of vitreous-soluble protein was found closely associated with the rate of retinal vessel growth. As vascularization progressed toward completion, the protein originally present at birth decreased to a negligible or undetected amount. Intravitreal neovascularization was produced in young puppies by exposure to 85 per cent oxygen for four days, then removal to room air. This form of neovascularization resembles closely that observed in human proliferative diabetic retinopathy. The oxygen treatment, which initially produced retinal capillary closure, then neovascularization, was associated with a retention of vitreous-soluble protein at a high level for several days. The results raise the possibility that the vitreous protein(s) may be fundamentally involved in the process of normal vascularization of the retina and in retinal neovascularization.
Critical Success Factors for Inter-Organizational Process Collaboration in eHealth (2014)

Abstract – In most Western countries, there is substantial growth in inter-organizational cooperation in design and delivery of health services based on Internet technology. However, there is a gap in the literature describing these efforts, and future research as well as practice can benefit from more elaborate theoretical models to understand this phenomenon. In order to close this gap, this study reviews the literature on Business Process Management in an inter-organizational context with a special focus on factors that can explain the success of process development in inter-organizational contexts. The review identifies several critical success factors that may be important as a starting point for future research in eHealth.
ChemInform Abstract: Deposition and Properties of Low‐Pressure Chemical‐Vapor Deposited Polycrystalline Silicon‐Germanium Films. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Split-TurboID enables contact-dependent proximity labeling in cells (2020)

Proximity labeling catalyzed by promiscuous enzymes, such as TurboID, have enabled the proteomic analysis of subcellular regions difficult or impossible to access by conventional fractionation-based approaches. Yet some cellular regions, such as organelle contact sites, remain out of reach for current PL methods. To address this limitation, we split the enzyme TurboID into two inactive fragments that recombine when driven together by a protein-protein interaction or membrane-membrane apposition. At endoplasmic reticulum-mitochondria contact sites, reconstituted TurboID catalyzed spatially restricted biotinylation, enabling the enrichment and identification of >100 endogenous proteins, including many not previously linked to endoplasmic reticulum-mitochondria contacts. We validated eight candidates by biochemical fractionation and overexpression imaging. Overall, split-TurboID is a versatile tool for conditional and spatially specific proximity labeling in cells.
Current use of complementary and conventional medicine for treatment of pediatric patients with gastrointestinal disorders (2023)

Infants, children, and adolescents are at risk of experiencing a multitude of gastrointestinal disorders (GID). These disorders can adversely affect the quality of life or be life-threatening. Various interventions that span the conventional and complementary therapeutic categories have been developed. Nowadays, parents increasingly seek complementary options for their children to use concurrently with conventional therapies. Due to the high prevalence and morbidity of diarrhea, constipation, and irritable bowel syndrome (IBS) in children, in this review, we decided to focus on the current state of the evidence for conventional and complementary therapies used for the treatment of these diseases in children. Diarrhea treatment focuses on the identification of the cause and fluid management. Oral rehydration with supplementation of deficient micronutrients, especially zinc, is well established and recommended. Some probiotic strains have shown promise in reducing the duration of diarrhea. For the management of constipation, available clinical trials are insufficient for conclusive recommendations of dietary modifications, including increased use of fruit juice, fiber, and fluid. However, the role of laxatives as conventional treatment is becoming more established. Polyethylene glycol is the most studied, with lactulose, milk of magnesia, mineral oil, bisacodyl, and senna presenting as viable alternatives. Conventional treatments of the abdominal pain associated with IBS are poorly studied in children. Available studies investigating the effectiveness of antidepressants on abdominal pain in children with IBS were inconclusive. At the same time, probiotics and peppermint oil have a fair record of benefits and safety. The overall body of evidence indicates that a careful balance of conventional and complementary treatment strategies may be required to manage gastrointestinal conditions in children.