gebhart/patrepeval huggingface dataset:
Mob-1 expression in IL-2-induced ARDS: regulation by TNF-alpha (1995)

We have recently established an animal model of adult respiratory distress syndrome (ARDS)-like microvascular lung injury elicited by infusion of human interleukin-2 (IL-2). Based on the pronounced, transcriptional upregulation of multiple pro-inflammatory mediators in IL-2-induced ARDS, differential display was applied to search for potentially novel genes in this paradigm of lung injury. Differential display on total lung RNA derived from IL-2-challenged rats presented a highly reproducible 3'-UTR fragment profile in which a band (approximately 250 bp), termed B1, was strongly induced. B1 cDNA sequence exhibited 99.14% homology to the 3'-UTR of mob-1, a recently cloned gene belonging to the C-X-C chemokine superfamily. Furthermore, Northern blot analysis showed that IL-2-induced pulmonary mob-1 mRNA was expressed at time points before the onset of lung injury and suppressed after TNF-alpha inhibition. These data imply that lung mob-1 is a novel, highly inducible gene in a clinically relevant model of ARDS and, based on its identification as a chemokine, could participate in the development of lung injury.
Interruption of the Homing Events of Phytopathogenic Aphanomyces cochlioides Zoospores by Secondary Metabolites from Nonhost Amaranthus gangeticus (2004)

On the screening of 200 nonhost plants, an Amaranthus gangeticus extract was found to attract and subsequently inhibit the motility of Aphanomyces cochlioides zoospores. The attractant was identified as a rare N-trans-feruloyl-4-O-methyldopamine (1) and the motility inhibitor as nicotinamide (2) using bioassay-guided fractionation and spectroscopic methods. The attractant had no inhibitory effect on zoospore motility whereas 2 immediately halted the motility and caused encystment in a dose-dependent manner (MIC, 5×10−8 M). Interestingly, the cystospores produced by 2 regenerated zoospores instead of germinating. Concomitant application of 1 and 2 produced cystospores that germinated to give hyphae. Preliminary TLC examinations revealed that Am. gangeticus seedling exuded sufficient amounts of nicotinamide from the roots. These results suggest that exudation of nicotinamide from Am. gangeticus might be involved in its resistance against the soilborne oomycete phytopathogen A. cochlioides.
Palliative treatment of obstructive esophageal cancer by vascular targeted photodynamic therapy (VTP): Preclinical study in orthotopic rat model. (2016)

59 Background: Vascular targeted photodynamic therapy (VTP) based on local sensitization of circulating WST11 (Pd-bacteriochlorophyll), enables effective focal ablation of solid tumors. WST11 clears from the circulation with t1/2 ~40 min (in humans) and does not accumulate in tissues which assures high level of safety and minimal adverse effects. Here we evaluate WST11-VTP for the treatment of obstructive esophageal cancer aiming at developing clinically relevant protocol. Methods: Using endoscopy guided procedure rat esophageal cancer cells (JA) were implanted in the mid esophagus. Following intravenous infusion of WST11, established tumors were illuminated by cylindrical fiber using the same endoscope sleeve. Safety and efficacy were evaluated by monitoring animal weight shift and histology of treated esophageal tissues. Treated animals included control (light/no WST11 or WST11/no light), WST11-VTP and WST11-VTP following treatment with bevacizumab at day -3. Results: WST11-VTP on esophageal tissues resulted in coagulative necrosis of the tumor graft and prolonged survival as evident by Kaplan—Meyer curves. The impact was confined to the illuminated site without signs of perforation or death. Following Bevacizumab, WST11-VTP showed similar results while control groups showed no effect. All treated animals started to regain weight at day 7 after VTP. Esophageal tissue and function was completely restored. Conclusions: WST11-VTP could be safely applied for the treatment of esophageal tumors, with only transient and mild adverse effect that are not affected by previous, clinically relevant treatment such as Bevacizumab application. Importantly, VTP effectively eradicated established esophageal tumors and could be translated into a clinical treatment protocol.
Enumerating sector organisation and industrial arrangements in Cultural and Creative Sector production chains (2021)

This CICERONE paper (D3.4) presents an overview of the sectoral organisation of the creative economy in Europe. It does so by considering the distribution of firm size within industries, interactions between firms within the cultural and creative sectors (CCS), and the trends and market dynamics impacting these interactions. When considering these issues, it applies the Global Production Network perspective, thereby trying to explore why production network typologies are changing form and how power structures within these networks shift. The series of which this paper is part is to inform European, national and regional policy frameworks for the CCS (and the wider economy) by grasping the challenges of the new and emergent organisational and governance forms of the creative economy. In this paper, we observe, among others, that CCS in Europe are constrained by their fragmentation (both on the demand and supply sides) to engage in forms of collective action. Constituting a myriad of small and medium-sized players, largely characterised by precarious, short-term, part time working conditions, it is hard for the CCS as a whole to speak with one voice. Next to that, collaborations in the CCS seem increasingly shaped by place-based cluster dynamics, but also sector-based (cross-border) platformisation. While place-based clusters speak to local and national policymaking, making culture and creative sectors an argument for territorial attractivity, platformisation links much more to an European policy agenda, with digital, copyrights and competition policies being particularly instrumental in setting market field for CCS.
Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis (2019)

Abstract Organisms are defined by their genomes, yet many distinguishing features of a given organism are encoded by genes that are functionally unannotated. Mycobacterium tuberculosis ( Mtb ), the leading cause of death due to a single microbe, co-evolved with humans as its only known natural reservoir, yet the factors mediating Mtb’s pathogenicity remain incompletely defined. rv3722c is a gene of unknown function predicted to encode a pyridoxal phosphate binding protein and to be essential for in vitro growth of Mtb . Using metabolomic, genetic and structural approaches, we show that Rv3722c is the primary aspartate aminotransferase of Mtb and mediates an essential but underrecognized role in metabolism: nitrogen distribution. Together with the attenuation of Rv3722c-deficient Mtb in macrophages and mice, these results identify aspartate biosynthesis and nitrogen distribution as potential species-selective drug targets in Mtb .
d ‐Dimer Level After Endovascular Treatment Can Help Predict Outcome of Acute Ischemic Stroke (2023)

URL: http://www.clinicaltrials.gov; Unique identifier: NCT02964052.
Investigations of SNR for a short-wave infrared intensity interferometer (2011)

Intensity interferometery holds tremendous potential for remote sensing of space objects. Whereas spatial resolution of imagery obtained from earth-based observatories is typically limited by both the size of the primary mirror and atmospheric effects, intensity interferometers (IIs) are relatively unaffected by atmospheric distortions and their effective apertures can be substantially larger than is practical for traditional observatories. Most intensity interferometer measurements have been performed in the visible region due to well-known issues of poor signal to noise ratios and the performance of detectors in the visible spectral bands. In fact the short-wave infrared (SWIR) spectral band is relatively unexplored for II applications. In this paper we investigate the measurement signal to noise terms for a notional SWIR intensity interferometer. Our study goes beyond the most basic SNR equations of II, and analyzes atmospheric effects, sky backgrounds, and detector characteristics, considering the current state-of-the-art for experiments in the short-wave infrared spectral region.
MBE-Grown Si : Er Light-Emitting Structures: Effect of Epitaxial Growth Conditions on Impurity Concentration and Photoluminescence (2005)

The technology and properties of light-emitting structures based on silicon layers doped by erbium during epitaxial MBE growth are studied. The epitaxial layer forming on substrates prepared from Czochralski-grown silicon becomes doped by oxygen and carbon impurities in the process. This permits simplification of the Si: Er layer doping by luminescence-activating impurities, thus eliminating the need to make a special capillary for introducing them into the growth chamber from the vapor phase. The photoluminescence spectra of all the structures studied at 78 K are dominated by an Er-containing center whose emission line peaks at 1.542 μm. The intensity of this line measured as a function of the substrate and erbium dopant source temperatures over the ranges 400–700°C and 740–800°C, respectively, exhibits maxima. The edge luminescence and the P line observed in the PL spectra are excited predominantly in the substrate. The erbium atom concentration in the epitaxial layers grown at a substrate temperature of 600°C was studied by Rutherford proton backscattering and exhibits an exponential dependence on the erbium source temperature with an activation energy of ∼2.2 eV.
Impact of Snoring on Telomere Shortening in Adolescents with Atopic Diseases (2021)

Atopic diseases can impose a significant burden on children and adolescents. Telomere length is a cellular marker of aging reflecting the impact of cumulative stress exposure on individual health. Since elevated oxidative stress and inflammation burden induced by chronic atopy and snoring may impact telomere length, this study aimed to investigate whether snoring would moderate the relationship between atopic diseases and telomere length in early adolescence. We surveyed 354 adolescents and their parents. Parents reported the adolescents' history of atopic diseases, recent snoring history as well as other family sociodemographic characteristics. Buccal swab samples were also collected from the adolescents for telomere length determination. Independent and combined effects of atopic diseases and snoring on telomere length were examined. Among the surveyed adolescents, 174 were reported by parents to have atopic diseases (20 had asthma, 145 had allergic rhinitis, 53 had eczema, and 25 had food allergy). Shorter TL was found in participants with a history of snoring and atopic diseases (β = -0.34, <i>p</i> = 0.002) particularly for asthma (β = -0.21, <i>p</i> = 0.007) and allergic rhinitis (β = -0.22, <i>p</i> = 0.023). Our findings suggest that snoring in atopic patients has important implications for accelerated telomere shortening. Proper management of atopic symptoms at an early age is important for the alleviation of long-term health consequences at the cellular level.
The Douglas-Peucker line simplification algorithm (1988)

The aim of this paper is to introduce the reader to one theme in digital cartography, namely line simplification. The paper describes the technique developed by David Douglas and Thomas Peucker in 1973. The reader is encouraged to experiment with data of their own choice using software supplied in the appendices, and provide feedback on the performance of this algorithm. -Authors
Reconstitution of the S. aureus agr quorum sensing pathway reveals a direct role for the integral membrane protease MroQ in pheromone biosynthesis (2021)

Abstract In Staphylococcus aureus , virulence is under the control of a quorum sensing (QS) circuit encoded in the accessory gene regulator ( agr ) genomic locus. Key to this pathogenic behavior is the production and signaling activity of a secreted pheromone, the autoinducing peptide (AIP), generated following the ribosomal synthesis and post-translational modification of a precursor polypeptide, AgrD, through two discrete cleavage steps. The integral membrane protease AgrB is known to catalyze the first processing event, generating the AIP biosynthetic intermediate, AgrD (1-32) thiolactone. However, the identity of the second protease in this biosynthetic pathway, which removes an N-terminal leader sequence, has remained ambiguous. Here, we show that MroQ, an integral membrane protease recently implicated in the agr response, is directly involved in AIP production. Genetic complementation and biochemical experiments reveal that MroQ proteolytic activity is required for AIP biosynthesis in agr specifiy groups -I and -II, but not group-III. Notably, as part of this effort, the biosynthesis and AIP-sensing arms of the QS circuit were reconstituted together in vitro . Our experiments also reveal the molecular features guiding MroQ cleavage activity, a critical factor in defining agr specificity group identity. Collectively, our study adds to the molecular understanding of the agr response and Staphylococcus aureus virulence.
<title>Detecting image purpose in World Wide Web documents</title> (1998)

The number of WWW documents available to users of the Internet is growing at an incredible rate. Therefore, it is becoming increasingly important to develop systems that aid users in searching, filtering, and retrieving information from the Internet. Currently, only a few prototype systems catalog and index images in Web documents. To greatly improve the cataloging and indexing of images on the Web, we have developed a prototype rule-based systems that detects the content images in Web documents. Content images are images that are associated with the main content of Web documents, as opposed to a multitude of other images that exist in Web documents for different purposes, such as decorative, advertisement and logo images. We present a system that uses decision tree learning for automated rule induction for the content images detection system. The system uses visual features, text-related features and the document context of images in concert for fast and effective content image detection in Web documents. We have evaluated the system by collecting more than 1200 images from 4 different Web sites and we have achieved an overall classification accuracy of 84 percent.
Stabilized Co-Simulation of Coupled Problems Including Fields and Signals (2014)

Das Berechnungsverfahren Co-Simulation wird mehr und mehr zu einer integralen und unverzichtbaren Methode zur Lsung der heutigen anspruchsvollen technischen Fragestel
ChemInform Abstract: SYNTHESIS AND TUBERCULOSTATIC ACTIVITY OF (5‐ARYL‐2‐FURYL)ARYLCARBINOLS AND THEIR ETHERS (1976)

Abstract Die nach Meerwein aus den Diazoniumsalzen (I) und den Ketonen (II) hergestellten Aryl‐aroylfurane (III) werden zu Benzylderivaten und Carbinolen reduziert.
Wind energy utilization possibilities in Turkey (1981)

An overview of the wind energy utilization problems is presented. Wind speed maps of Turkey for each month are drawn separately, based on previous records extending over twenty to thirty years. Possibilities of wind energy utilization in Turkey are discussed. 5 refs.
Improved Decoding Algorithms of LDPC Codes Based on Reliability Metrics of Variable Nodes (2019)

The informed dynamic scheduling (IDS) strategies for decoding of low-density parity-check codes obtained superior performance in error correction performance and convergence speed. However, there are still two problems existing in the current IDS algorithms. The first is that the current IDS algorithms only preferentially update the selected unreliable messages, but they do not guarantee the updating is performed with reliable information. In this paper, a two-step message selecting strategy is introduced. On the basis of the two reliability metrics and two types of variable node residuals, the residual belief propagation (BP) decoding algorithm, short for TRM-TVRBP, is proposed. With the algorithm, the reliability of the updating-messages can be improved. The second is the greediness problem, prevalently existed in the IDS-like algorithms. The problem arises mainly from the fact that the major computing resources are allocated to or concentrated on some nodes and edges. To overcome the problem, the reliability metric-based RBP algorithm (RM-RBP) is proposed, which can force every variable node to contribute its intrinsic information to the iterative decoding. At the same time, the algorithm can force the related variable nodes to be updated, and make every edge have an equal opportunity of being updated. The simulation results show that both the TRM-TVRBP and the RM-RBP have appealing convergence rate and error-correcting performance compared with the previous IDS decoders over the white Gaussian noise (AWGN) channel.
Surface Work Function of Transparent Conductive ZnO Films (2012)

The influence of Al doped on work function of ZnO thin film with C-axis preferred orientation were analyzed both theoretically and experimentally. Pure ZnO and Al-doped ZnO(ZnO:Al) films were deposited on n-type Si substrate by radio frequency (RF) magnetron sputtering. Surface work function were calculated using the first-principles with pseudopotential method based on density-functional theory (DFT) of ZnO and ZnO:Al surface structure. It was found that the theoretical value of work function of (002) plane ZnO and ZnO:Al were 5.076ev and 4.978ev respectively. Following I-V-T characteristics of the heterojunctions were investigated, the work function of ZnO and ZnO:Al were obtained at 4.71ev and 4.62ev, respectively. Al doped led to the value of work function reduced by 0.09ev, which was consistent with 0.098ev calculated by the first-principle algorithm.
26 km-long polarisation-maintaining optical fibre (1987)

The letter describes the development of a long-length and large-diameter preform for polarisation-maintaining optical fibres. The preform was 470 mm in length and 48 mm in diameter. As a result, a 26 km-long PANDA fibre is developed. This fibre achieves crosstalk of –22 dB, corresponding to h = 2.4 × 10-7m-1 and a transmission loss of 0.3 dB/km at a wavelength of 1.56 μm. These fibres will be useful for future high-speed and medium-span coherent optical communications.
Deregulated Balance of Omega-6 and Omega-3 Polyunsaturated Fatty Acids following Infection by the Zoonotic Pathogen Streptococcus suis (2014)

Streptococcus suis is an important swine pathogen and an emergent zoonotic pathogen. Excessive inflammation caused by S. suis is responsible for early high mortality in septic shock-like syndrome cases. Polyunsaturated fatty acids (PUFAs) may contribute to regulating inflammatory processes. This study shows that mouse infection by S. suis is accompanied by an increase of arachidonic acid, a proinflammatory omega-6 (ω-6) PUFA, and by a decrease of docosahexaenoic acid, an anti-inflammatory ω-3 PUFA. Macrophages infected with S. suis showed activation of mitogen-activated protein kinase pathways and cyclooxygenase-2 upregulation. Fenretinide, a synthetic vitamin A analog, reduced in vitro expression of inflammatory mediators. Pretreatment of mice with fenretinide significantly improved their survival by reducing systemic proinflammatory cytokines during the acute phase of an S. suis infection. These findings indicate a beneficial effect of fenretinide in diminishing the expression of inflammation and improving survival during an acute infection by a virulent S. suis strain.
Efficient self-consistent quantum transport simulator for quantum devices (2014)

We present a self-consistent one-dimensional (1D) quantum transport simulator based on the Contact Block Reduction (CBR) method, aiming for very fast and robust transport simulation of 1D quantum devices. Applying the general CBR approach to 1D open systems results in a set of very simple equations that are derived and given in detail for the first time. The charge self-consistency of the coupled CBR-Poisson equations is achieved by using the predictor-corrector iteration scheme with the optional Anderson acceleration. In addition, we introduce a new way to convert an equilibrium electrostatic barrier potential calculated from an external simulator to an effective doping profile, which is then used by the CBR-Poisson code for transport simulation of the barrier under non-zero biases. The code has been applied to simulate the quantum transport in a double barrier structure and across a tunnel barrier in a silicon double quantum dot. Extremely fast self-consistent 1D simulations of the differential conductance across a tunnel barrier in the quantum dot show better qualitative agreement with experiment than non-self-consistent simulations.
Evaluation of ABR congestion control protocols for ATM LAN and WAN (2002)

This paper evaluates and compares six rate-based congestion control protocols for the ABR (available bit rate) traffic over the ATM (asynchronous transfer mode) networks. They include: the EFCI-bit setting, the EFCI-bit setting with separate RM queues, the CI-bit setting in the backward direction, the CI-bit setting in the backward direction with separate RM queues, the CAPC2 ER (explicit rate) scheme, and the EFCI-bit setting with utilization-based congestion indication. Each scheme is simulated and compared in the LAN, WAN, and GFC (general fairness configuration) environments specified by the ATM Forum. The effects of varying the VC (virtual circuits) number and changing the endsystem-switch distance has been investigated. Their fairness is also compared using the GFC configuration. For each simulation run, we measure the average queueing delay, maximum queue length, and network utilization. Traces of the ACR (allowed cell rate) and buffer queue length are also examined. We have found that the ER control scheme performs significantly better than the other five binary control schemes by its faster response to congestion, smoother regulation of bit rates, lower queueing delay, shorter buffer queue length, and fairness. Among the other five schemes, the CI-bit setting scheme performs better than the EFCI (explicit forward congestion indication) bit setting scheme. Providing separate RM queues has significantly improved the EFCI scheme in the WAN environment, but has little effect on the CI scheme. Link utilization-based congestion detection has suffered from either low utilization or an excess cell loss which is unacceptable in most data applications.
RF/optical interference design for optical intersatellite links (1990)

A design approach for the RF/optical link interface for a data relay satellite is described. The flexibility of forward and return links in future data acquisition satellites in handling varying missions and data rates to 1 Gbit/s is considered. Attention is focused on requirements for the NASA Tracking and Data Acquisition System. System components are described including the return link multiplexer, the return link transmultiplexer, the forward link multiplexer, the forward link demultiplexer, and the frontside/backside switch. Ping-pong buffers, which provide rate buffering for each input data stream, are discussed and justification bits, which handle variations due to Doppler shift and local oscillator variation, are considered. The time-division multiplexed streams consist of a unique synchronization word for frame synchronization, and control words associated with each data burst to identify the presence or absence of a justification bit. Redundant data paths are described for both forward and return data streams.
Can Suicide Be Prevented (2011)

Major mood disorders have been associated with increased suicidal behavior. This is especially true in patients with a mixed, manic-depressive, or dysphoric-agitated state.