gebhart/patrepeval huggingface dataset:
Preparation of Atherosclerotic Model by the Cuff Method and Effects of Drugs on the Atherosclerosis (1986)

In order to clarify the mechanisms underlying atherogenesis, we studied effects of drugs on the arterial intimal thickening induced in rabbits by the cuff method. Under pentobarbital anesthesia, the carotid artery was sheathed with a cuff made of a polyethylene tube (1.5cm long PE-280). Animals were given normal diet and water ad lib., and i. m. drugs 5 times a week for 3 weeks. After sacrifice, their sheathed arteries were observed histologically. Although non-treated arteries had no intimal thickening, smooth muscle cells appeared in the intima after the cuff-treatment. Intimal thickening increased gradually and reached its peak 3 weeks after the cuff-treatment, and it shrank thereafter. Inflammatory changes were observed in the adventitia throughout the experimental period.Scanning electron microscopy revealed endothelial injury after the cuff-treatment. A number of leukocytes and platelets adhered to the exposed internal elastic laminae 1 day after the cuff-treatment. Injured endothelium began to repair within 3 days, and almost complete recovery from the damage was attained 2 weeks thereafter. Dexamethasone inhibited both intimal thickening and adventitial inflammation in a dose-dependent manner (0.01-10mg/kg), but more than 1mg/kg of dexamethasone made animals thin remarkably. A calcium antagonist FR34235 inhibited the intimal thickening in a dose-dependent manner (0.01-10mg/kg), and had no effect on animals' weight. These results suggest that passing endothelial injury and adventitial inflammation are involved in the atherogenesis by the cuff-treatment, and this method is a suitable model to estimate antiatherogenic effect of drugs. A calcium antagonist FR34235 is expected to be an antiatherogenic agent.
Rate Maximization for Partially Connected Hybrid Beamforming in Single-User MIMO Systems (2018)

Partially connected hybrid beamforming (HBF) is a promising approach to alleviate the implementation of large scale millimeter-wave multiple-input multiple-output (MIMO) systems. In this paper, we develop rate maximizing algorithms for the full array-and subarray-based processing strategies of partially connected HBF. We formulate the rate maximization problem as a weighted mean square error minimization problem and use alternating optimization to tackle it. Numerical results show that partially connected HBF provides a good balance between hardware complexity and performance in comparison to optimal fully digital and analog beamforming. Moreover, the simpler subarray-based HBF algorithm achieves comparable performance to that of the full array-based approach in medium and high SNRs. The rate maximizing results serve as upper bounds for lower complexity heuristic methods.
Characterization of the yeast ionome: a genome-wide analysis of nutrient mineral and trace element homeostasis in Saccharomyces cerevisiae (2005)

Our results indicate the power of ionomics to identify new aspects of mineral homeostasis and how these data can be used to develop hypotheses regarding the functions of previously uncharacterized genes.
In-Situ Observations and Pressure Measurements for Autoclave Co-Cure of Honeycomb Core Sandwich Structures (2017)

In this paper we describe an experimental method for investigating the autoclave co-cure of honeycomb core composite sandwich structures. The design and capabilities of a custom-built, lab-scale “in-situ co-cure fixture” are presented, including procedures and representative results for three types of experiments. The first type of experiment involves measuring changes in gas pressure on either side of a prepreg laminate to determine the prepreg air permeability. The second type involves co-curing composite samples using regulated, constant pressures, to study material behaviors in controlled conditions. For the final type, “realistic” co-cure, samples are processed in conditions mimicking autoclave cure, where the gas pressure in the honeycomb core evolves naturally due to the competing effects of air evacuation and moisture desorption from the core cell walls. The in-situ co-cure fixture contains temperature and pressure sensors, and derives its name from a glass window that enables direct in-situ visual observation of the skin/core bond-line during processing, shedding light on physical phenomena that are not observable in a traditional manufacturing setting. The experiments presented here are a first step within a larger research effort, whose long-term goal is to develop a physics-based process model for autoclave co-cure.
Structure and Morphology of Odd Polyoxamides [Nylon 9,2]. A New Example of Hydrogen-Bonding Interactions in Two Different Directions (1998)

The structure and morphology of nylon 9,2 has been investigated using transmission electron microscopy, selected area electron diffraction, and X-ray diffraction. A unit cell with parameters a = 5.45 Å, b = 8.7 Å, c (chain axis) = 31.8 Å, and β = 47.9° was determined and a C12/c1 space group is postulated. Chain conformation is practically all-trans, but the torsion angles of the NH−CH2 bonds slightly deviate from 180° in order to optimize the hydrogen-bonding interactions between neighboring chains. A structure with two directions of hydrogen bonding is derived, although the unit cell is strongly related to that found in nylon 6,6. Crystallization from the melt and temperature-induced structural changes have also been studied.
Expression of novel nitrate reductase genes in the harmful alga, Chattonella subsalsa (2018)

Eukaryotic nitrate reductase (NR) catalyzes the first step in nitrate assimilation and is regulated transcriptionally in response to external cues and intracellular metabolic status. NRs are also regulated post-translationally in plants by phosphorylation and binding of 14-3-3 proteins at conserved serine residues. 14-3-3 binding motifs have not previously been identified in algal NRs. A novel NR (NR2-2/2HbN) with a 2/2 hemoglobin domain was recently described in the alga Chattonella subsalsa. Here, a second NR (NR3) in C. subsalsa is described with a 14-3-3 binding motif but lacking the Heme-Fe domain found in other NRs. Transcriptional regulation of both NRs was examined in C. subsalsa, revealing differential gene expression over a diel light cycle, but not under constant light. NR2 transcripts increased with a decrease in temperature, while NR3 remained unchanged. NR2 and NR3 transcript levels were not inhibited by growth on ammonium, suggesting constitutive expression of these genes. Results indicate that Chattonella responds to environmental conditions and intracellular metabolic status by differentially regulating NR transcription, with potential for post-translational regulation of NR3. A survey of algal NRs also revealed the presence of 14-3-3 binding motifs in other algal species, indicating the need for future research on regulation of algal NRs.
Spectral shaping of UWB signals for time-hopping impulse radio (2006)

This paper studies the design of signaling waveforms for time-hopping impulse radio (TH-IR) with limits on the power spectral density. Such restrictions are imposed by the spectral mask prescribed by frequency regulators for ultra-wideband (UWB) signals. The "conventional" TH-IR system with pulse-position modulation and time-hopping multiple access gives rise to spectral lines that either violate the regulations, or require a significant power backoff. To remedy this situation, we propose the use of polarity randomization, which eliminates the spectral lines and also leads to a smoothing of the continuous part of the spectrum. We analyze different variants of the polarity randomization, considering short and long randomization sequences, as well as symbol-based or pulse-based randomization. We analyze the effect of this technique on both pulse position modulation and binary phase-shift keying modulation.
Complications of Combined Surgery and Neutron Radiation Therapy in Patients with Advanced Carcinoma of the Head and Neck (1979)

A total of 135 patients with advanced squamous-cell carcinoma of the head and neck were treated with cyclotron-generated fast neutrons. Thirty-eight had major surgery before or after irradiation. Major complications (fistula formation, carotid artery exposure or blowout requiring ligation, or major wound breakdown) occurred in 37%. The complication rates associated with surgery prior to irradiation, planned surgery following irradiation, and salvage surgery following irradiation were 0/12, 4/5, and 10/21, respectively. The complication rate for surgery following neutron irradiation alone was 73%; for surgery following mixed-beam irradiation it was 20%. The age of the patient and the interval between surgery and irradiation had no influence on the complication rate.
ENVIRONMENTAL FACTORS EFFECTING INFLAMMATORY BOWEL DISEASE ACTIVITY (2004)

Purpose: Inflammatory bowel disease (IBD) is a waxing and waning illness with many modulating environmental factors effecting disease activity. Many of these environmental factors are not well established and studies evaluating the effects of seasonal variation, menstrual cycle, NSAID ingestion, stress and dietary intake have yielded controversial results. The purpose of this study was to further examine the relationship of several of these factors, thought to influence disease activity, to patient's perceived disease activity. Methods: This was a retrospective study involving 30 patients with IBD within the greater Chicago area (mean age = 51, 17 women, 13 men). Sixteen patients with Crohn's disease and 14 patients with Ulcerative Colitis were administered a telephone questionnaire designed to assess patient's perceived disease activity in correlation with variables such as season, stress, menstrual cycle, NSAID use, OCP use, and several dietary factors. Results were analyzed using one way chi-squared analysis. Results: 73% of all patients reported increased symptoms with increased life stress (p = .01). 53% of all patients reported a perceived seasonal variation in their symptoms, with 50% of these reporting worse symptoms in winter, 25% in summer, 12.5% in spring and 12.5% in fall (p = 0.72). 36% of patients reported increased symptoms post dairy intake (p = 0.14). Among menstruating women, 40% reported increased symptoms during menstruation (p = 0.43). Of the patients who drank alcohol, 43% reported increased symptoms post EtOH ingestion (p = 0.51). Only 23% of patients reported worsening of symptoms with sugar intake and 27% of patients reported increased symptoms post NSAID use (p = .003 and p = 0.01 respectively, significant for not effecting perceived symptoms). Conclusions: Our study found a significant association between life stress and perceived inflammatory bowel disease activity. Although trends were noted, our study reveals no significant association between perceived disease activity and season, dairy intake, menstruation, EtOH intake, sugar ingestion or NSAID use. Larger prospective studies focused on the influence of environmental factors and more specifically the role of stress and the therapeutic benefits of stress management on disease activity are warranted.
Bandwidth allocation for non-responsive flows with active queue management (2003)

This paper addresses the problem of configuring active queue management systems (e.g. WRED and RIO) for service level specifications in internetworks. In particular, we focus on assured forwarding (AF) for non-responsive flows in differentiated services networks. The difficulty is to determine the correct queue level thresholds that will result in correct drop rates for various AF precedence levels under any combination of offered loads. A new active queue management scheme based on a control algorithm is proposed that senses not only queue levels but also rates of queue levels changes and per flow bit rates to converge automatically to an optimal set of transmit fractions. The scheme has been implemented and tested on a network processor. Results show that the new active queue management scheme protects assured aggregated flow rates during periods of congestion. For non-responsive traffic the buffer occupancy level remains low during 250% offered load.
Data protection in outsourcing scenarios (2010)

Data outsourcing is an emerging paradigm that allows users and companies to give their (potentially sensitive) data to external servers that then become responsible for their storage, management, and dissemination. Although data outsourcing provides many benefits, especially for parties with limited resources for managing an ever more increasing amount of data, it introduces new privacy and security concerns. In this paper we discuss the main privacy issues to be addressed in data outsourcing, ranging from data confidentiality to data utility. We then illustrate the main research directions being investigated for providing effective data protection to data externally stored and for enabling their querying.
A new phytogeographic proposal based on the endemic monocots of the Iberian Península and the Baleario Islands (1997)

A new proposal to establish floristic regions in the Iberian Península and the Balearte Islands, based on their endemic monocots, is presented. The data matrix was built with 182 species and subspecies mapped on the UTM 10 x 10 km grid, and using the TWINSPAN programme for classification. The 2094 squares with chorological information were divided into 10 sectors with subsectors. These sectors do not cover the whole studied territory due to the lack of chorological data for some regions. Some Iberian áreas belonged to a single sector, while in others a combination of sectors was a notable feature. Results are discussed taking into account previous proposals to delimit Iberian and Balearic fitogeographical áreas, and the principal endemic floristic characters, which it has been possible to differentiate, from the point of view of their distribution, are emphasized.
Assessment of impact of information and ballistic launch support factors on mission realizability by aircraft formations (2021)

Sensitivity plays an important role in the analysis and synthesis of technical systems no matter what complexity or purpose, that is in assessing their accuracy, determining and selecting tolerances for their parameters, or in any optimization process. One of the most important objectives of the information and ballistic launch support, along with the provision of launch data, is to increase the efficiency of aircraft in performing their missions. Therefore, it is of high relevance to assess the function of sensitivity and the function of influence of the information and ballistic launch support on the effectiveness of the functional performance of aircraft formations and ensure, at acceptable costs, the fullest use of their structural and ballistic capabilities. In this paper, we defined and evaluated functions of sensitivity and functions of influence of the main factors of information and ballistic launch support of aircraft launches on their functional performance as a formation. The degree of influence of information and ballistic support factors on the realizability of missions by aircraft formations is represented by numerical indicators. An integral indicator for assessing the impact of information and ballistic support factors on the performance indicators of aircraft formations has been formed as a weighted convolution of increments of partial indicators.
Catalytic synthesis and photoluminescence of β-Ga2O3 nanowires (2001)

Monoclinic gallium oxide (β-Ga2O3) nanowires were synthesized by heat treating a composite material of GaAs and pre-evaporated Au at 1240 °C in dry oxygen atmosphere. The catalytic Au metal generated liquid nanoclusters that serve as reactive sites confining and directing the growth of β-Ga2O3 nanowires during the vapor-liquid-solid growth process. The β-Ga2O3 nanowires have diameters ranging from 20 to 50 nm and lengths of several micrometers. Photoluminescence measurement under excitation at 250 nm shows that the bulk β-Ga2O3 nanowires have a stable blue emission at 475 nm and an ultraviolet emission at 330 nm, which may be related to the defects such as the oxygen vacancy and the gallium–oxygen vacancy pair.
TAP-XL (2003)

The TAP-XL Automated Analyst's Assistant is an application designed to help an English-speaking analyst write a topical report, culling information from a large inflow of multilingual, multimedia data. It gives users the ability to spend their time finding more data relevant to their task, and gives them translingual reach into other languages by leveraging human language technology.
Stool Microbiota at Neutrophil Recovery Is Predictive for Severe Acute Graft vs Host Disease After Hematopoietic Cell Transplantation (2017)

The stool microbiota around the time of neutrophil recovery post-HCT is predictive of subsequent development of severe acute GVHD in this study.
Immunophenotypic and genotypic characteristics of chronic myelogenous leukemia in blast crisis. (2000)

Clonal rearrangement of the IgH gene was found mostly in cases of Ly-BC and Mix-BC. We found that CML-BC with clonal rearrangement of the IgH gene had a more favorable prognosis than in cases with a germline configuration.
Genetic organization and characteristics of the 3-(3-hydroxyphenyl)propionic acid degradation pathway of Comamonas testosteroni TA441 (1999)

Comamonas testosteroni TA441 degrades 3-(3-hydroxyphenyl)propionate (3HPP) via the meta pathway. A gene cluster required for degradation of 3HPP was cloned from strain TA441 and sequenced. The genes encoding six catabolic enzymes, a flavin-type hydroxylase (mhpA), extradiol dioxygenase (mhpB), 2-keto-4-pentenoate hydratase (mhpD), acetaldehyde dehydrogenase (acylating) (mhpF), 4-hydroxy-2-ketovalerate aldolase (mhpE) and the meta cleavage compound hydrolase (mhpC), were found in this cluster, encoded in this order. mhpD and mhpF were separated by two genes, orf4 and orf5, which were not necessary for growth on 3HPP. The gene mhpR, encoding a putative transcriptional activator of the IcIR family, was located adjacent to mhpA in the opposite orientation. Disruption of the mhpB or mhpR genes affected growth on 3HPP or trans-3-hydroxycinnamate. The mhpB and mhpC gene products showed high specificity for 3-(2,3-dihydroxyphenyl)propionate (DHPP) and the meta cleavage compound produced from DHPP, respectively.
[Purification and identification of human leukocyte myeloperoxidase]. (1990)

Myeloperoxidase (MPO) plays an important role in the oxygen-dependent microbicidal mechanism of polymorphonuclear neutrophils. The purpose of our study was to investigate the therapeutic potency of human MPO preparations. This paper is to present our work on MPO purification and its identification. White blood cells, isolated freshly from normal donors, were lysed with cetyltrimethylammonium bromide to liberate myeloperoxidase. The purified MPO was obtained by 65% (NH4)2SO4 precipitation followed by separation over the Sephadex G150 column. These pure MPO preparations were green in color and had an A430/A280 nm of 0.68. The enzymatic activity was of 29.77 u/mg. The pure normal MPO was composed of a 59,000 MW peptide, a 13,500 MW peptide, and a 38,000 MW peptide when subjected to SDS-PAGE under reducing conditions. The study of the therapeutic effect of the pure MPO on mice with C. albicans infection is under way.
Calcium oxide and strontium oxide as environmentally benign and highly efficient heterogeneous catalysts for the Tishchenko reaction of furfural (2001)

CaO and SrO exhibit high activities for the challenging Tishchenko reaction of furfural.
Compositional, strain contour and property mapping of CdZnTe boules and wafers (1993)

The authors have developed detailed non-destructive mapping and spatial imaging techniques for comparing boule and wafer properties with analytical predictions from high-fidelity process models for seeded vertical Bridgman-Stockbarger growth of CdZnTe crystals. They have emphasized the prediction of the magnitude and distribution of residual stress and strain, as well as longitudinal and radial segregation within the boules and across wafers cut from the boules. Boule and wafer compositional distributions were mapped using photoreflectance, precision lattice parameter measurements and FTIR spectroscopy. Defect and strain distributions within the boules and wafers were imaged using synchrotron topography, synchrotron strain contour mapping, and double-crystal rocking-curve mapping. Thermomechanical and thermosolutal models specifically addressing the seeded vertical Bridgman-Stockbarger growth of CdZnTe crystals were developed and empiricized. These models addressed solute redistribution and stress generation as a result of the interface shape, aspect ratio and growth parameters during the seeding, initial transient (including the shoulder), steady-state and terminal transient regions of the boule. Finally, the stress and strain distributions on specific wafers 'cut' from the processed (modelled) boules were predicted and X-ray synchrotron strain contour, double-crystal rocking-curve, FTIR, and photoreflectance maps were generated on the real wafers for comparison. Implications of these results with respect to substrate quality, screening, performance and producibility, will be discussed.
Substrate Specificity in Photocatalytic Degradation of Mixtures of Organic Contaminants in Water (2016)

TiO<sub>2</sub>-induced photocatalytic decomposition of methyl orange (MO) and atrazine in aqueous solutions was investigated using a top illumination reactor and LC-MS analysis. TiO<sub>2</sub> P25 was determined to be the most favorable catalyst when compared to TiO<sub>2</sub> Hombikat or Pt-promoted P25 (0.5% Pt/P25). For all catalysts, a strong substrate specificity was observed when simultaneous decomposition was attempted at neutral pH or acidic conditions: MO decomposition was largely preferred over decomposition of atrazine. For TiO<sub>2</sub> P25, several process parameters were varied (catalyst loading, MO initial concentration, pH) to determine that the cause of this observation is preferential adsorption. Atrazine decomposition was no longer inhibited by MO at (i) large catalyst concentrations, (ii) at a low MO over atrazine ration, and (iii) at basic conditions (pH 11). Apparently the surface charge of illuminated TiO<sub>2</sub> significantly affects the degradation behavior of contaminants when present in mixtures. Surface specificity is not limited to a combination of MO and atrazine, but for P25, this is also shown to occur in decomposition of a mixture of MO and acid orange (AO), compounds with similarity in molecular structure. Consequences of the results for practical application of photocatalysis for water decontamination are briefly discussed.
Identification of new structural 1-benzoyl isoquinolines obtained by oxidation of papaverine. (1987)

Papaverine 1 was oxidized by vanadium pentoxide in 2.5 M aqueous sulfuric acid media to give four new compounds : 4-hydroxy-6-demethylpapaveraldine (3), 4-hydroxy-4'-demethylpapaveraldine (4), 3-hydroxy-6-demethylpapaveraldine (5) and 3-hydroxy-4'-demethylpapaveraldine (6). The structures were established on the basis of mass spectrometry, ultraviolet-infrared spectrometry, nuclear magnetic resonance measurements and also chemical correlation with papaveraldine 2.