gebhart/patrepeval huggingface dataset:
Deletion of G Protein–Coupled Estrogen Receptor Increases Endothelial Vasoconstriction (2011)

Endogenous estrogens mediate protective effects in the cardiovascular system, affecting both endothelium-dependent and endothelium-independent mechanisms. Previous studies have suggested that nonselective estrogen receptor agonists such as endogenous estrogens inhibit endothelium-dependent vasoconstriction; however, the role of estrogen receptors in this response has not yet been clarified. This study investigated whether the intracellular transmembrane G protein-coupled estrogen receptor (GPER) regulates vascular reactivity in mice. Effects of chronic deficiency (using mice lacking the GPER gene) and acute inhibition (using the GPER-selective antagonist G15) on endothelium-dependent and endothelium-independent vascular reactivity, and the effects of GPER deficiency on vascular gene expression and structure were investigated. We found that chronic GPER deficiency is associated with increased endothelial prostanoid-mediated vasoconstriction but has no effect on endothelial nitric oxide bioactivity, gene expression of endothelial nitric oxide synthase and thromboxane prostanoid (TP) receptor, or vascular structure. GPER deletion also increases TP receptor-mediated contraction. Acute GPER blockade enhances endothelium-dependent contractions and reduces endothelial nitric oxide bioactivity. Contractions in response to TP receptor activation are unaffected by G15. In conclusion, this study identifies GPER as the first estrogen receptor with inhibitory activity on endothelium-dependent contractility. These findings may be important for understanding and treating diseases associated with increased endothelial vasoconstrictor prostanoid activity such as hypertension and obesity.
Atomic layer deposition of AlN on different SiC surfaces (2022)

Abstract Thin AlN films were grown using a Picosun R-200 atomic layer deposition (ALD) reactor on SiC surfaces with different crystallographic orientation: on-axis 4H-SiC (0001) and 8° off-axis 4H-SiC. TMA (trimethylaluminium) and NH 3 were used as precursors while hydrogen and nitrogen plasma were applied for in-situ substrate cleaning. The substrate temperatures were 400 °C and 450 °C, with 20 ALD cycles. The surface morphology was investigated by scanning electron microscopy (SEM), which revealed nanometer-sized islands in all films. The AlN films deposited on on-axis 4H-SiC at 450 °C substrate temperature exhibited a relatively small roughness of about 0.255 nm. The chemical composition and bonding states were investigated by X-ray photoelectron spectroscopy. For all layers, high-resolution XPS showed Al 2p and N 1s spectra that are characteristic of AlN. These results are a good prerequisite of establishing the growth conditions of AlN films for surface acoustic wave (SAW) devices.
Protective Effect of Andrographis paniculata against Oxidative Damage in C2C12 Skeletal Muscle Cells (2022)

Eunjeong Seong, Hyeonjeong Choe, Huijin Heo, Hana Lee, Mansu Kim, Younghwa Kim, Heon Sang Jeong, and Junsoo Lee. Journal of the Korean Society of Food Science and Nutrition 2022;51:1259-65. https://doi.org/10.3746/jkfn.2022.51.12.1259
Prevalence and correlates of sleep apnea among US Veterans with chronic kidney disease (2020)

The prevalence and correlates of sleep apnea (SA) among Veterans with chronic kidney disease (CKD), a population at high risk of both SA and CKD, are unknown. We performed a cross-sectional analysis of 248 Veterans (18-89 years) selected only for presence of moderate to severe CKD. All participants underwent full, unattended polysomnography, measurement of renal function and a sleepiness questionnaire. Logistic regression with backward selection was used to identify predictors of prevalent SA (apnea-hypopnea index [AHI, ≥15 events/hr] and prevalent nocturnal hypoxia [NH, % of total sleep time spent at <90% oxygen saturation]). The mean age of our cohort was 73.2 ± 9.6 years, 95% were male, 78% were Caucasian and the mean body mass index (BMI) was 30.3 ± 4.8 kg/m<sup>2</sup> . The prevalence of SA was 39%. There was no difference in daytime sleepiness among those with and without SA. In the final model, older age, higher BMI and diabetes mellitus (DM) were associated with higher odds of SA, after controlling for age, BMI, race and sex. Higher BMI, DM, unemployed/retired status, current smoking and higher serum bicarbonate level were associated with prevalent NH. To sum, SA was common among Veterans with moderate to severe CKD. Although some traditional risk factors for SA were associated with SA in this population, sleepiness did not correlate with SA. Further study is needed to validate our findings and understand how best to address the high burden of SA among Veterans with CKD.
High-power linearly-polarised Yb fibre laser and tunable Er,Yb fibre laser using Volume Bragg Gratings for wavelength selection (2008)

High-power linearly-polarised Yb fibre laser and tunable Er,Yb fibre laser using Volume Bragg Gratings for wavelength selection
Molecular Pathophysiology of Myofiber Injury in Deficiencies of the Dystrophin-Glycoprotein Complex (2002)

Duchenne muscular dystrophy is caused by mutations in the gene encoding dystrophin, a 427 kd protein normally found at the cytoplasmic face of the sarcolemma. In normal muscle, dystrophin is associated with a multimolecular glycoprotein complex. Primary mutations in the genes encoding members of this glycoprotein complex are also associated with muscular dystrophy. The dystrophin-glycoprotein complex provides a physical linkage between the internal cytoskeleton of myofibers and the extracellular matrix, but the precise functions of the dystrophin-glycoprotein complex remain uncertain. In this review, five potential pathogenetic mechanisms implicated in the initiation of myofiber injury in dystrophin-glycoprotein complex deficiencies are discussed: (1) mechanical weakening of the sarcolemma, (2) inappropriate calcium influx, (3) aberrant cell signaling, (4) increased oxidative stress, and (5) recurrent muscle ischemia. Particular emphasis is placed on the multifunctional nature of the dystrophin-glycoprotein complex and the fact that the above mechanisms are in no way mutually exclusive and may interact with one another to a significant degree.
Live Stream Temporally Embedded 3D Human Body Pose and Shape Estimation (2022)

3D Human body pose and shape estimation within a temporal sequence can be quite critical for understanding human behavior. Despite the significant progress in human pose estimation in the recent years, which are often based on single images or videos, human motion estimation on live stream videos is still a rarely-touched area considering its special requirements for real-time output and temporal consistency. To address this problem, we present a temporally embedded 3D human body pose and shape estimation (TePose) method to improve the accuracy and temporal consistency of pose estimation in live stream videos. TePose uses previous predictions as a bridge to feedback the error for better estimation in the current frame and to learn the correspondence between data frames and predictions in the history. A multi-scale spatio-temporal graph convolutional network is presented as the motion discriminator for adversarial training using datasets without any 3D labeling. We propose a sequential data loading strategy to meet the special start-to-end data processing requirement of live stream. We demonstrate the importance of each proposed module with extensive experiments. The results show the effectiveness of TePose on widely-used human pose benchmarks with state-of-the-art performance.
Enzyme‐catalyzed polyester synthesis in organic medium: Ring‐chain equilibrium (1997)

Abstract Enzyme‐catalyzed synthesis of aliphatic, unsaturated and semi‐aromatic polyesters from methyl diesters and diols was carried out in toluene at 60°C in the presence of supported lipases. Whatever the monomer structure, rings were formed concurrently to linear chains excepted when dimethyl fumarate was used. The yield of rings depends on several parameters such as the monomer structure and the initial concentration of the reactive functions and strongly influences the average molar masses of the unfractionated samples. For aliphatic, unsaturated and semi‐aromatic polyesters, the molar cyclization equilibrium constants ( K ) were determined and it would appear that the molar distribution of the ringed species obeys Jacobson‐Stockmayer equation: Ln K = Ln B − 5/2 Ln n , where B and n represent a constant and the number of monomer units of each type in the ring, respectively.
Scaring lines—An innovative and flexible solution for the Nephrops fishery (FLEXSELECT) (2019)

The FLEXSELECT project set out to develop and demonstrate a simple and efficient system that could be quickly coupled to any existing demersal trawl to reduce the catch of fish. For example, to improve the species selection in the Danish mixed demersal trawl fishery targeting Norway lobster. The principle of FLEXSELECT is the same as what is currently used today to herd fish into the path of the trawl, however, the scaring lines are mounted in a way that instead of herding the fish into the path of the trawl, they direct unwanted fish away from the trawl’s path so that they do not enter the trawl itself. This approach is somewhat different to most of the work that has been carried out to improve species and size selection in demersal trawls. A majority of the work has concentrated around different solution in and around the codend itself, as opposed to the introduction of simple devices ahead of the trawl that are capable of altering the catch composition. The development and testing of the FLEXSELECT scaring lines took place on board R/V Havfisken in 2016 and 2017 and aimed at establishing the design principle, testing different design parameters, and developing a coupling system that makes it easy to assemble and disassemble to ensure maximum flexibility. Based on the results from the first trials, commercial testing was carried out together with the commercial fishing vessel FN 436 Tove Kajgaard. As part of the commercial trials, further design parameters were tested, a final prototype was produced and tested under commercial conditions. The results obtained show that FLEXSELECT is a simple, cheap and effective selective device that can reduce the catch of fish bycatch, especially roundfish, in the mixed demersal trawl fishery targeting Norway lobster. Moreover, the device has the advantage to be applicable only when required, at the haul-by-haul level (e.g. in response to the availability of quotas or bycatch hotspots), and it can be easily adjusted to fit any trawl size. Furthermore, its applicability extends to any demersal trawl fishery wanting to reduced unwanted catches of fish. The project was completed during the period 07-09-2016 until 23-08-2019 by DTU Aqua with participation from The Danish Fishermen’s Association. This report provides and overview of the work undertaken during the project and presents the results from the individual trials. Furthermore, the report highlights some of the challenges which arose during the project and how these can be addressed in the future.
Inhibition of Depolarization‐Induced Nitric Oxide Synthase Activation by NS‐7, a Phenylpyrimidine Derivative, in Primary Neuronal Culture (1998)

Neuronal nitric oxide synthase (NOS) is considered to be involved in the pathogenesis of ischemic brain damage. In the present study, the effect of a novel neuroprotective phenylpyrimidine derivative, 4-(4-fluorophenyl)-2-methyl-6-(5-piperidinopentyloxy)pyrimidine hydrochloride (NS-7), on depolarization-stimulated NOS activity was examined in cultured neurons of mouse cerebral cortex. Various depolarizing stimuli such as veratridine, KCl, and N-methyl-D-aspartate increased the NOS activity determined by cyclic GMP formation. NS-7 concentration-dependently inhibited both the veratridine- and KCl-induced NOS activation with IC50 values of 9.3 and 9.6 microM, respectively. The reversal of KCl-evoked NOS activity by NS-7 was also observed under blockade of both ionotropic glutamate receptors and the Na+ channel with MK-801, 6-cyano-7-nitroquinoxaline-2,3-dione, and tetrodotoxin. In contrast, NS-7, even at 100 microM, did not affect N-methyl-D-aspartate-stimulated NOS activity, nor did it have any influence on NOS activity determined in the soluble fraction of rat hippocampus. Because NS-7 has already been shown to block both Na+ and Ca2+ channels, the present findings suggest that this compound inhibits depolarization-induced NOS activation by reducing Ca2+ influx through blockade of Na+ and Ca2+ channels in primary neuronal culture.
Nucleosomal Structures of c-myc Promoters with Transcriptionally Engaged RNA Polymerase II (1997)

Organization of DNA into chromatin has been shown to contribute to a repressed state of gene transcription. Disruption of nucleosomal structure is observed in response to gene induction, suggesting a model in which RNA polymerase II (pol II) is recruited to the promoter upon reorganization of nucleosomes. Here we show that induction of c-myc transcription correlates with the disruption of two nucleosomes in the upstream promoter region. This nucleosomal disruption, however, is not necessary for the binding of pol II to the promoter. Transcriptionally engaged pol II complexes can be detected when the upstream chromatin is in a more closed configuration. Thus, upstream chromatin opening is suggested to affect activation of promoter-bound pol II rather than entry of polymerases into the promoter. Interestingly, pol II complexes are detectable in both sense and antisense transcriptional directions, but only complexes in the sense direction respond to activation signals resulting in processive transcription.
Strategic information systems selection with incomplete preferences: a case of a Korean electronics company (2007)

This paper presents an interactive procedure with incomplete information for supporting corporate strategic information systems planning (SISP), which is based on a prescriptive group decision-making method showing how to aggregate experts' incomplete preference judgments. The system, named CoSIS, is suggested on the competency leverage concept for selecting technical or organizational enablers to attain organizational business objectives. We put the competencies between the objectives and enablers, measure the importance rates of competencies on the objectives, and derive target enablers for the company. The importance of a competency is calculated using the SISP experts' incomplete preference information regarding relationships of importance rates between competencies on each objective. The Web-based architecture of CoSIS makes it relatively easy for the SISP team to obtain this preference information from distributed experts. Using the system, we carry out the experiments for performance evaluation of our procedure.
Deterioration of Terrazzo (2010)

Terrazzo installation is often perceived as an art, left to individual contractors and craftsmen to implement tried-and-true application and repair methods. In this context, architects and engineers often relegate themselves to a minimal supervisory role during construction and planning. The writers have found several recurring instances of terrazzo cracking problems during construction as well as deterioration that could be prevented or minimized with attention to the responsibilities of all parties to communicate throughout the design process. Causes are often related to shrinkage of terrazzo, concentrated stresses attributable to configuration of divider strips, and impact loads. To objectively minimize deterioration rates of terrazzo, an experimental program was initiated to evaluate performance. Testing consisted of compressive strength and linear shrinkage tests on cementitious terrazzo under varying curing conditions and a durability test that applied a cyclic gravity wheel load to gaps at the edge of terrazzo tiles. The latter test used metal wheels and considered parameters of material type, gap size between terrazzo edge and adjacent steel plate, wheel diameter, vertical offset of tile, and vertical load being applied. Results indicated that proper curing of cementitious terrazzo is critical to achieving compressive strength and minimizing early shrinkage. For the durability test performed, epoxy terrazzo exhibited significantly less deterioration. Durability of terrazzo is affected primarily by gap size, upward vertical offset, and weight applied. Small wheel size and direction of loading can also contribute to deterioration. It is important that architects, engineers, and contractors understand methods that ensure material properties, minimize stress concentrations, and use appropriate divider strip spacing to minimize deterioration attributable to cracking and impact load. These steps will ensure the visual appearance and durability expected by the project team.
All-optical implementation of a time-domain ptychographic pulse reconstruction setup: publisher’s note (2016)

This note reports author corrections that were omitted from Appl. Opt.55, 5008 (2016) 10.1364/AO.55.005008 in error during production. The article was corrected online 23 June 2016.
Ion-beam-assisted deposition of thermally evaporated Cr thin films (1994)

Optical, electrical, and microstructural properties of thermally evaporated Cr thin films assisted by the low-energy Ar ion beam were investigated. The result shows that the optical and electrical properties are close to those of the corresponding bulk Cr: both refractive index and extinction coefficient increase, reflectance increases, and electrical resistivity decreases. The tensile stress decreases while the grain size changes slightly. From this experimental study, it is found that the low-energy Ar ion beam bombardment on growing Cr films modifies the microstructure of Cr films to improve the optical and electrical properties.
N-(5-Bromopyrimidin-4-yl)cyclopropanecarboxamide (2007)

In the title compound, C8H8BrN3O, a combination of `hard' N—H⋯O and `soft' C—H⋯N inter­actions help to consolidate chains of mol­ecules in the crystal structure.
Tunable RF noise suppressor modeling using soft magnetic film on coplanar transmission line (2004)

In this paper, we estimated the tunable rf electromagnetic noise attenuation by ferromagnetic resonance on transmission line without the external magnetic fields, which is analyzed by the finite element method a commercial simulation package.
Direct torque control induction motor drives with self-commissioning based on Taguchi methodology (2000)

This paper presents the analysis and design of direct torque control (DTC) induction motor drives with self-commissioning. Neither motor parameters nor controller parameters are known a priori. The self-commissioning process consists of the calculation of motor parameters, including stator resistor, inertia and friction coefficient, as well as the design of the controller. The effects of several factors, including test conditions for deriving motor mechanical parameters and natural frequency for controller design, on the performance of speed response are investigated using Taguchi's method which is widely used in quality engineering to significantly reduce the number of experiments. Therefore, the presented drive system cannot only provide self-commissioning but also dramatically improve the performance of speed response, which is evaluated using the performance index of root-mean-squared error (RMSE) of speed. Experimental results derived from a PC-based experimental system are presented to fully support the theoretical development and analysis.
Decade tuning, wide IF instrumentation receiver (2008)

This paper describes the development of the receive section of an instrumentation transceiver. The radio is designed for high linearity, gain and phase flatness, and is capable of tuning from 0.4-4 GHz in 1 Hz steps with an IF bandwidth of 20 MHz. Its performance is intended to be capable of testing 2G, 3G, LTE, and WIMAX systems. A high first IF avoids multiple switched filters while maintaining good spurious performance. The design uses SMT packaged MMIC amplifiers and mixers, microstrip, coaxial resonator, and lumped element filter technologies and a high performance synthesiser architecture based around off-the-shelf VCOs. A 16 bit 130 MHz ADC takes the signal into the digital domain for final down conversion to complex base-band. Two high performance FPGAs are used for this processing and also implementation of digital equalisation and applying calibration offsets. A high speed serial link to further processing is available for further filtering and software defined demodulators. (5 pages)
Investigation of the crystalline "V" amylose complexes by high-resolution carbon-13 CP/MAS NMR spectroscopy (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInvestigation of the crystalline "V" amylose complexes by high-resolution carbon-13 CP/MAS NMR spectroscopyR. P. Veregin, C. A. Fyfe, and R. H. MarchessaultCite this: Macromolecules 1987, 20, 12, 3007–3012Publication Date (Print):May 1, 1987Publication History Published online1 May 2002Published inissue 1 May 1987https://pubs.acs.org/doi/10.1021/ma00178a010https://doi.org/10.1021/ma00178a010research-articleACS PublicationsRequest reuse permissionsArticle Views270Altmetric-Citations62LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Convergent Born series improves the accuracy of numerical solution of time-independent photoacoustic wave equation (2020)

This work presents two variants of Born-series methods, for the first time, providing a numerical solution to the time-independent photoacoustic wave equation. These methods are effective in providing accurate solution even when there is a mismatch in speed-of-sound between the source and the ambient region. The traditional Born-series (TBS) and convergent Born-series (CBS) methods have been systematically compared for a test imaging case. The solution was computed keeping speed-of-sound outside the source as constant (1500 m/s) and varying the same quantity from 1950 to 1200 m/s inside the source (a disc with 5 μm radius) over a large frequency band (7–2000 MHz). The TBS method fails to converge when the variation in the speed-of-sound is approximately >22% or <−11%. The CBS method provides the required robust numerical solution even in case of mismatch in speed-of-sound in various regions of imaging domain.