gebhart/patrepeval huggingface dataset:
Infantile Hemangioma: A Tumor Involving Hemogenic Endothelium with Erythropoetic Potential (2010)

Abstract Abstract 4305 Background Infantile hemangioma (IH) is a tumor of the microvasculature predominantly composed of proliferating endothelial cells, but also contains progenitor cells of mesenchymal and hematopoietic lineages. We have previously shown that IH has a primitive mesodermal origin. Here we investigated expression of hematopoietic associated proteins (Tal-1, GATA-2, CD133 &amp; CD34) as well as the erythropoietin receptor (EPOR) and the embryonically-associated hemoglobin zeta chain (HBZ) by both the cells of the endothelium and the cells emanating from proliferating IH explants. Additionally we investigated if the cells emanating from the explants generate erythrocytes in vitro. Purpose To investigate the expression of hematopoietic associated proteins and the primitive erythropoietic capacity of proliferating IH. Methods Proliferating IH biopsies from 5 patients were (i) processed for IHC staining for Tal-1, GATA-2, CD133, CD34, HBZ and EPOR; (ii) used to determine the relative expression of Tal-1, GATA-2, CD133, CD34, HBZ &amp; EPOR transcripts by qRT-PCR; (ii) cultured as explants using our in vitro model and differentiated the cells down the erythropoietic lineage. Results IHC showed that the cells that line the endothelium forming the capillaries of proliferating IH expressed Tal-1, GATA-2, CD133, CD34, HBZ and EPOR. qRT-PCR confirmed the IHC data as abundant expression mRNA transcripts for the same proteins was detected in both the tissue and the cells emanating from the cultured explants. Following 5 months in culture morphological biconcave cells were visible, and were confirmed to be erythrocytes by immunoreactivity to the erythrocyte-specific cell surface marker glycophorin A. Conclusion The mRNA and protein expression of hematopoietic associated proteins in proliferating IH supports our previous studies showing this tumor expressing markers of primitive mesoderm and confirms a hemogenic endothelium phenotype. The expression of the primitive erythropoiesis-associated proteins HBZ and EPOR by proliferating IH and its functional ability of proliferating IH explants to form erythrocytes in vitro confirms the erythropoietic potential. Proliferating IH thus represents an extra-medullary site of tumor-associated erythropoiesis. Disclosures: No relevant conflicts of interest to declare.
Nutritional interest of aleuron layer of wheat seed (2003)

La couche a aleurone est une couche histologique localisee a la peripherie du grain de ble entre l'albumen amylace et les enveloppes. Elle est, avec l'embryon, l'unique tissu vivant du grain mature et permet son developpement au cours de la germination. Elle assure a la fois un role nourricier via le stockage de metabolites et la synthese d'enzymes d'hydrolyse des reserves, et un role de protection grâce a sa structure parietale resistante. La couche a aleurone est un tissu complexe qui renferme des concentrations importantes de molecules d'interet nutritionnel. Cette revue bibliographique veut faire l'etat des connaissances sur la microstructure et la composition biochimique de ce tissu pour servir de base au developpement de technologies adaptees a la valorisation de son contenu en micronutriments
Metal-promoted transformation of carbon dioxide into carbon monoxide. X-ray crystal structure of the nickel-carbonate complex [O:PPh2CH2C(CH3)(CH2PPh2)2]Ni(O2CO).0.5H2O.C6H6 (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetal-promoted transformation of carbon dioxide into carbon monoxide. X-ray crystal structure of the nickel-carbonate complex [O:PPh2CH2C(CH3)(CH2PPh2)2]Ni(O2CO).0.5H2O.C6H6Claudio Bianchini, Carlo Mealli, Andrea Meli, and Michal SabatCite this: Inorg. Chem. 1984, 23, 18, 2731–2732Publication Date (Print):August 1, 1984Publication History Published online1 May 2002Published inissue 1 August 1984https://pubs.acs.org/doi/10.1021/ic00186a002https://doi.org/10.1021/ic00186a002research-articleACS PublicationsRequest reuse permissionsArticle Views278Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Fully Integrated High-Voltage Generators with Optimized Power Efficiency (2014)

This paper describes how the power efficiency of fully integrated Dickson charge pumps in high- voltage IC technologies can be improved considerably by implementing charge recycling techniques, by replacing the normal PN junction diodes by pulse-driven active diodes, and by choosing an appropriate advanced smart power IC technology. A detailed analysis reveals that the combination of these 3 methods more than doubles the power efficiency compared to traditional Dickson charge pump designs.
The contact lens corneal cutter: accuracy and reproducibility. (1982)

The contact lens corneal cutter was used on ten freshly enucleated pig eyes in an attempt to determine its accuracy and reproducibility. We felt that a circular opening could be obtained; however, there was variability in the size of the tissue cut and a disparity between the internal and external openings, which was caused by the sharp angle of the cutting blade.
A phase I clinical trial of binimetinib in combination with FOLFOX in patients with advanced metastatic colorectal cancer who failed prior standard therapy (2017)

Oral binimetinib and FOLFOX has a manageable toxicity profile and showed some evidence of antitumor activity in heavily pretreated mCRC patients.
Introduction to the Special Issue on Model Order Selection in Signal Processing Systems (2010)

The 18 papers in this special issue focus on model order selection in signal processing systems.
A New Method to Warm Up Lubricating Oil to Improve the Fuel Efficiency During Cold Start (2011)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;Cold start driving cycles exhibit an increase in friction losses due to the low temperatures of metal and media compared to normal operating engine conditions. These friction losses are responsible for up to 10% penalty in fuel economy over the official drive cycles like the New European Drive Cycle (NEDC), where the temperature of the oil even at the end of the 1180 s of the drive cycle is below the fully warmed up values of between 100°C and 120°C. At engine oil temperatures below 100°C the water from the blowby condensates and dilutes the engine oil in the oil pan which negatively affects engine wear. Therefore engine oil temperatures above 100°C are desirable to minimize engine wear through blowby condensate. The paper presents a new technique to warm up the engine oil that significantly reduces the friction losses and therefore also reduces the fuel economy penalty during a 22°C cold start NEDC. Chassis dynamometer experiments demonstrated fuel economy improvements of over 7% as well as significant emission reductions by rapidly increasing the oil temperature. Oil temperatures were increased by up to 60°C during certain parts of the NEDC.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;It is shown how a very simple sensitivity analysis can be used to assess the relative size or efficiency of different heat transfer passes and the resulting fuel economy improvement potential of different heat recovery systems system. Due to its simplicity the method is very fast to use and therefore also very cost effective. The method demonstrated a very good correlation for the fuel consumption within ±1% compared to measurements on a vehicle chassis roll.&lt;/div&gt;&lt;/div&gt;
Production Tubing String Design for Optimum Gas Recovery (2006)

Abstract This paper presents the results of an investigation of the design of production tubing string setting depths in gas wells to optimize gas recovery in wells that produce free liquids in conjunction with the gas. Particularly important in this work has been the evaluation of the conditions for which the well outflow velocity is less than that which would be required to continuously transport and unload liquids from the well. Sub-critical velocities are often encountered in low productivity gas wells that produce liquids, whether the wellbore liquids are produced directly from the formation and/or condensed from the gas in the wellbore. The produced liquids considered in the analysis can be water and/or liquid hydrocarbons. This paper presents an optimization technique for determining the most efficient production tubing string setting depth design that will keep the wellbore continuously unloaded of produced liquids, yet result in the maximum gas recovery possible under those conditions. The optimization can be performed for a single completion operation during the productive life of the well, or for a series of periodic well interventions during the productive life of the well for which the tubing string setting depths are selected. The wellbore liquid-loading mechanism in a sub-critical velocity production system has been considered in the analysis using a mechanistic wellbore outflow model. A commingled reservoir inflow performance model was utilized in the analysis to evaluate the fluid inflow of multilayer gas reservoirs that may produce liquids in conjunction with the gas.
Electron spin polarization in ferromagnetic metals (1976)

Various types of experiments which have bveen desgined to measure the electron spein polarization of ferromagnets are described. Results obtained for the 3d ferropmagnetic metals are given. The experimental results asre briefly discusased in relation to proposed theoretical interpretations and related experiments, with particular empohasis on tunneling. A phenomenological correlation between magnetic moment and electron spin polarization, which is observed in Fe, Co, and Ni, appears to be valid for Ni‐Mn and Ni‐Ti ferromagnetic alloys.
Sub-microliter Electrochemiluminescence Detector—A Model for Small Volume Analysis Systems (1997)

A small volume, electrochemical cell for the generation and detection of electrochemiluminescence from tris(2,2′-bipyridyl) ruthenium(II) has been fabricated. The flowcell is a poly(methyl methacrylate) (PMMA)–acetate–PMMA sandwich construct, containing two platinum, thin-film electrodes. Operation of the microchip establishes sub-microliter detection of tris(2,2′-bipyridyl) ruthenium(II) electrochemiluminescence in continuous flow. Initial experiments demonstrate a detection limit of 5 × 10–13M at an effective cell volume of 100 nl. This corresponds to the detection of only 30 000 molecules.
Kinetic modeling of perchloroethylene coal desulfurization process (1994)

Batch extraction data was used to model the hybrid mechanism of chemical reaction and physical solvation involved in the perchloroethylene coal desulfurization process. Two models, pseudo-first order and second order, are presented to represent the extraction mechanism. Multiple parameter estimates have been found which minimize the model-data discrepancies. Novel methods have been devised to illustrate multiple estimates of the kinetic parameters. Ill-posedness of the kinetic modeling problem has been analyzed using the expression for extractability and the Hessian matrix of the model-data discrepancy function. In an effort to present the sensitivity of parameters to the kinetic models, a novel method called eigenvalue analysis has been developed. A comparison is also made between the second order model and the pseudo-first order model.
Repetitive sp3−sp3 Carbon−Carbon Bond-Forming Copolymerizations of Primary and Tertiary Ylides. Synthesis of Substituted Carbon Backbone Polymers:  Poly(cyclopropylidine-co-methylidine) (2006)

We report a repetitive sp3−sp3 carbon−carbon bond-forming polymerization for the controlled synthesis of cyclopropyl containing carbon backbone polymers with tailored end groups and molecular weight. Poly(cyclopropylidine-co-methylidine) copolymers (10) were synthesized via copolymerization of (dimethylamino)tolyloxosulfonium cyclopropylide (11) with dimethylsulfonium methylide (8). The polymer was synthesized in Mn ranges from 1800 to 6714. The cyclopropyl:methyl incorporation ratios varied from 1:12 and 1:18. The composition of the poly(cyclopropylidine-co-methylidine) polymer (10) was established by NMR and IR. GPC revealed a monomodal distribution with PDI between 1.06 and 1.28. The cyclopropyl groups extend the range of functionality that can be incorporated into carbon backbone polymers and illustrate for the first time the use of tertiary ylides as monomers for the polymerization reaction. Direct control of the amount of cyclopropyl groups in the carbon backbone has potential for selective modification of the polymer by, for example, radical ring-opening reactions to create new topologies and cross-linking opportunities.
Black-White Comparisons of 20-Year Coronary Heart Disease Mortality in the Evans County Heart Study (1993)

The Evans County Heart Study was initiated to compare the epidemiology of coronary heart disease (CHD) of black and white residents of a southeastern United States community. The study was prompted by a clinical observation that CHD appeared to be less frequent in black than white patients, despite a much higher prevalence and greater severity of hypertension in blacks. A total community-based, closed cohort study was initiated with a prevalence survey in 1960-1962. The 20-year follow-up experience of the Evans County cohort confirmed the importance of the major risk factors of serum cholesterol, smoking and blood pressure for middle age and older, black and white men and women for CHD, cardiovascular disease (CVD) and all-cause mortality. Black men were less likely to die of CHD than white men, and this relative protectiveness increased upon adjusting for risk factors and also increased with age. The relative protectiveness of black men for CHD mortality was also reflected in lower black than white CVD and all-cause mortality in men 65 years of age and older.
OCT Detects Collagen Fiber Alignment in Human Cadaveric Lumbar Facet Capsular Ligament During Mechanical Loading (2012)

The lumbar facet capsular ligament (FCL) is a highly collagenous structure that functions to constrain lumbar spinal motion. Two FCLs are found at each level of the spine, flanking the spinous process. The ligament spans from the inferior articular process (IAP) of the superior vertebra to the superior articular process (SAP) of the inferior vertebra forming the posterior portion of the facet capsule (Figure 1). Along with the anteriorly located ligamentum flavum, the FCL contains the synovial fluid that lubricates the facet joint. The facet capsule is highly innervated [1] and may be involved in low back pain or proprioception. Thus, changes in collagen fiber alignment from mechanical loading may activate mechanoreceptors leading to proprioception or nociceptors leading to pain.
The Effect of Initial Conditions on the Laminar Flame Front Velocity in Gas Mixtures (2021)

In this paper, we consider the scatter of the laminar flame front velocities caused both by an error in the composition of the combustible mixture and by artificial initial disturbances. It is shown how the configuration of the initial perturbations of an initially flat front of a laminar flame in a gas mixture with the constant composition affects the velocity spread of expanding spherical flames. The effect of the error in the composition of the combustible mixture on the parameters that determine the flame front velocity was analyzed from the literature data on the spread of the flame propagation velocity. These parameters were recalculated for the possible variation in the mixture composition obtained based on the data on the accuracy of the equipment used in the experiments.
[Etiological analysis of fever in the first 24 hours following allogeneic peripheral stem cell transfusion]. (2012)

To investigate the incidence and pathogenesis of fever within the first 24 hours following allogeneic peripheral stem cell transfusion and to analyze the associated risk factors.Totally 114 patients received allogeneic hematopoietic stem cell transplantation (allo-HSCT) between October 2009 and August 2010 were enrolled and clinical data of febrile patients within 24 hours following peripheral stem cell transfusion were retrospectively analyzed. Multivariate logistic regression analysis was performed to identify the risk factors for transfusion related fever.Thirty-two (28.1%) out of the 114 patients had a fever within 24 hours after allo-HSCT. All of them were human leukocyte antigen (HLA) mismatch transplantation. The median time of the temperature elevated was 2.5 (0 - 18.0) hours after the infusion with a median time of the peak of 7.8 (3.5 - 23.0) hours after the infusion. Fever was attributed to definite infection in 6 patients and no definite infection in the remaining 26 patients. None of them were hemolytic, which was attributed to transfusion related fever. Multivariate analysis showed that female donor and high count of peripheral leukocyte of donor peripheral blood were significant predictors for transfusion related fever.Most of post-infusion fever within 24 hours after HLA mismatch related transplantation has no identifiable infectious focus. The risk factors for transfusion related fever are female donor and high number of peripheral leukocyte of donor blood.
Hematopoietic stem cell transplantation in children with acute leukemia: similar outcomes in recipients of umbilical cord blood versus marrow or peripheral blood stem cells from related or unrelated donors (2012)

Survival after UCB transplantation was similar to survival after MRD and URD transplantation. For patients lacking an HLA matched donor, the use of UCB is a suitable alternative.
Application of the Chiral Poisoning Strategy:  Enantioselective Diels−Alder Catalysis with a Racemic Ru/BINAP-Monoxide Lewis Acid (2002)

A chiral poisoning strategy has been applied to the [(±)-p-cymeneRuCl(BINPO)]SbF6 (±1) catalyst system for the asymmetric Diels−Alder reaction between methacrolein and cyclopentadiene to produce enantioenriched exo-2-methylbicyclo[2.2.1]hept-5-ene-2-carboxaldehyde. When ±1 was mixed with AgSbF6, the dicationic Lewis acid [(±)-p-cymeneRu(H2O)(BINPO)](SbF6)2 (±2) was generated. The additions of a number of chiral poisons (P* = enantiopure ligand) were found to deactivate one of the enantiomers of the catalyst with varied levels of selectivity. The most effective chiral poison was either l-proline or l-prolinamide. In catalytic trials with l-proline, an ee of up to 54% was observed. In the case where a stoichiometric amount of (±)-Ru/methacrolein reacted in the presence of l-prolinamide, the DA product was obtained with ee = 60% (S), de = 96% (exo), and 92% conversion.
Integrative Toolkit to Analyze Cellular Signals: Forces, Motion, Morphology, and Fluorescence (2022)

Quantitative assessment of cellular forces and motion advanced considerably over the last four decades. These advancements provided the framework to examine insightful mechanical signaling processes in cell culture systems. However, the field currently faces three problems: lack of quality standardization of the acquired data, technical errors in data analysis and visualization, and perhaps most importantly, the technology remains largely out of reach for common cell biology laboratories. To overcome these limitations, we developed a new experimental platform - Integrative Toolkit to Analyze Cellular Signals (iTACS). iTACS consists of two components: Acquisition and Training Module (AcTrM) and Analysis and Visualization Module (AnViM). AcTrM is based on µManager - an NIH-ImageJ-based microscope control software - and facilitates user self-training and automation of common image acquisition protocols. AnViM is based on NIH-ImageJ and facilitates user-friendly automation of data analysis and insightful visualization of results. These experiments involve culturing adherent cells on hydrogels, imaging fiducial markers embedded in the hydrogel, and finally extracting from these images a comprehensive mechanical characterization of the cells. Currently, iTACS enables the user to analyze and track a wide array of properties, including morphology, motion, cytoskeletal forces, and fluorescence of individual cells and their neighboring region. The quality standardization issue was addressed in AcTrM with, a reference image-guided refocusing technique. The technical issues in data analysis were addressed in AnViM with a multi-pronged image segmentation procedure, a user-friendly approach to identify boundary conditions, and a novel cellular property-based data visualization. AcTrM is designed to facilitate the straightforward transformation of basic fluorescence microscopes into experimental cell mechanics rigs, and AnViM is equipped to enable users to measure cellular mechanical signals without requiring an engineering background. iTACS will be available to the research community as an open-source suite with community-driven development capabilities.
The influence of dysfunctional actin on polystyrene-nanotube-mediated mRNA nanoinjection into mammalian cells (2023)

The advancement of nanofabrication technologies has transformed the landscape of engineered nano-bio interfaces, especially with vertically aligned nanoneedles (NNs). This enables scientists to venture into new territories, widening NN applications into increasingly more complex cellular manipulation and interrogation. Specifically, for intracellular delivery application, NNs have been shown to mediate the delivery of various bioactive cargos into a wide range of cells-a physical method termed "nanoinjection". Silicon (Si) nanostructures demonstrated great potential in nanoinjection, whereas the use of polymeric NNs for nanoinjection has rarely been explored. Furthermore, the underlying mechanism of interaction at the cell-NN interface is subtle and multifaceted, and not fully understood-underpinned by the design versatility of the NN biointerface. Recent studies have suggested that actin dynamic plays a pivotal role influencing the delivery efficacy. In this study, we fabricated a new class of NNs-a programmable polymeric nanotubes (NTs)-from polystyrene (PS) cell cultureware, designed to facilitate mRNA delivery into mouse embryonic fibroblast GPE86 cells. The PSNT delivery platform was able to mediate mRNA delivery with high delivery efficiency (∼83%). We also investigated the role of actin cytoskeleton in PSNTs mediated intracellular delivery by introducing two actin inhibitors-cytochalasin D (Cyto D) and jasplakinolide (Jas)-to cause dysfunctional cytoskeleton, <i>via</i> inhibiting actin polymerization and depolymerization, respectively (before and after the establishment of cell-PSNT interface). By inhibiting actin dynamics 12 h before cell-PSNT interfacing (pre-interface treatment), the mRNA delivery efficiencies were significantly reduced to ∼3% for Cyto D-treated samples and ∼1% for Jas-treated sample, as compared to their post-interface (2 h after cell-PSNT interfacing) counterpart (∼46% and ∼68%, respectively). The added flexibility of PSNTs have shown to help withstand mechanical breakage stemming from cytoskeletal forces in contrast to the SiNTs. Such findings will step-change our capacity to use programmable polymeric NTs in fundamental cellular processes related to intracellular delivery.