gebhart/patrepeval huggingface dataset:
Cobalt‐Catalyzed Intramolecular Olefin Hydroarylation Leading to Dihydropyrroloindoles and Tetrahydropyridoindoles (2013)

Regiodivergente Katalyse: Cobaltkomplexe mit N-heterocyclischen Carbenliganden (NHC) katalysieren die intramolekulare Olefinhydroarylierung von Indolen mit anhängenden N-Homoallyl- oder Bis(homoallyl)-Einheiten und einer dirigierenden Aldimingruppe an C3. Unter milden Bedingungen entstehen Dihydropyrroloindole und Tetrahydropyridoindole, wobei der Cyclisierungsverlauf von der Brücke abhängt, aber über den NHC-Ligand gesteuert werden kann. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Phytochemsitry and Therapeutic Potential of Medicinal Plant: Dioscorea bulbifera (2015)

Dioscorea bulbifera is an immensely important medicinal plant which is extensively used in both Indian and Chinese system of traditional medicine. It is found in many parts of the world and has gained wide attention not only for health care but also as a food crop. It has attracted scientific interest owing to its numerous therapeutic applications in various pathophysiological conditions like ulcers, sores, wound, spasms, dysentery, diabetes and cancer. Spectacular success in extensive research particularly within last two decades has proven that these activities are attributed to its unique phytochemistry. Bioactive components from D. bulbifera have exhibited anti-oxidant, antiinflammatory, antibacterial, plasmid curing, antidiabetic and anticancer activities. It has become a model system in nanobiotechnology as it harbours phytochemicals with reducing, capping and shape modulating efficiencies. Numerous studies, either separately or in association, have aimed to explain the chemical composition and mechanisms behind its pharmacognostic significance. Similarly, many reports have documented and validated the claimed traditional usage by providing a strong scientific rationale. However, there is no review published on its in vitro, in vivo and in silico applications along with detailed phytochemistry. In view of the background, this review elaborates the complete phytochemistry of D. bulbifera with therapeutic importance.
Human bronchial smooth muscle cells in culture produce stem cell factor (1999)

A mast cell infiltration of the bronchial smooth muscle layer has been reported in patients sensitized to common allergens. Stem cell factor (SCF) is a chemotactic and survival factor for mast cells. SCF is expressed as a soluble (sSCF) and a membrane-bound (mSCF) form, after alternative splicing of the exon encoding the proteolytic cleavage site. SCF expression by human bronchial smooth muscle cells in culture was evaluated, comparing it to that of human lung fibroblasts in culture. sSCF released in the culture supernatant was assessed by an enzyme-linked immunosorbent assay. Total SCF messenger ribonucleic acid (mRNA) was measured by competitive polymerase chain reaction (PCR) after reverse transcription. Expression of the two forms of SCF mRNA was assessed by PCR, with primers spanning the alternatively spliced exon. Smooth muscle cells produced sSCF (21.9+/-2.6 pg x mL(-1)), although at lower levels than fibroblasts (35.9+/-3.5 pg x mL(-1)); the expression of total SCF mRNA was also at lower levels than in fibroblasts (8.6+/-0.2 and 19.0+/-2.0 amol x fmol glyceraldehyde 3-phosphate dehydrogenase complementary deoxyribonucleic acid(-1), respectively). However, smooth muscle cells expressed proportionally more (1.7-fold) mSCF mRNA than did fibroblasts. In conclusion, this study shows that bronchial smooth muscle cells express stem cell factor, with a relatively high expression of membrane-bound stem cell factor. This might be related to the presence of mast cells within the bronchial smooth muscle layer, i.e. at the site of bronchoconstriction, with possible implications in the pathophysiology of asthma.
Dithizone derivatives as sensitive water soluble chromogenic reagents for the ion chromatographic determination of inorganic and organo-mercury in aqueous matrices (2003)

Water-soluble sulfonate and the novel carboxylate analogues of dithizone, combined with ion interaction chromatography on a Dionex Acclaim 120 C18 silica column (250 x 4.6 mm id) with an eluent consisting of 10 mM tetrabutylammonium bromide and 60:40 methanol:water, have been developed as highly sensitive chromogenic ligands for the quantitative isocratic determination of inorganic and organo-mercury compounds in aqueous matrices in under 12 min. Using an optimised post column reagent system containing 0.65 mM dye, 0.5% Triton X-100 and 50 mM sodium hydroxide, good linearity (0-7.5 mg L(-1) R2 > 0.999), reproducibility using peak area measurements (RSD 0.69-1.38%, n = 8), and limits of detection (4-12 microg L(-1)) were achieved for methyl mercury, inorganic mercury and phenyl mercury.
Advanced Self-Discharge Measurements of Lithium-Ion Cells and Comparison to Modeling (2020)

Lithium-ion batteries (LIBs) are currently the most relevant energy storage solution for a wide field of applications starting from mobile communication and going to high power applications in electric vehicles. To assess the quality of a LIB either during production or in post-production, its self- discharge rate is an important parameter. Here we present a new method for precise potentiostatic self-discharge measurements (SDMs) that is very sensitive and considerably faster than other currently available methods. We validated the new SDM by measuring ten commercial 3000 mAh 21700 LIBs resulting in roughly 3 μA self-discharge current with a noise level of 0.1 μA, at 60% state of charge (SoC). Higher self- discharge currents of about 40 μA were observed at a higher SoC of 80%. To model the SDM, the electrochemical processes are coupled with a 3D temperature FEM and an electric circuit model of the cell self-discharge, resulting in a good overlap and a quantitative value of the LIB self-discharge resistance. Furthermore, we tested a realistic physical self-discharge scenario of the formation of Lithium dendrites by comparing experimental and modelled self-discharge resistance values.
Multi-dither adaptive optical system for laser beam shaping (2003)

We describe an adaptive optical closed loop system with bimorph mirror as a wavefront corrector and CCD camera at the focal plane of the lens as a sensor to obtain a good focal spot. Adaptive system can correct for the low-order aberrations with the frequency of corrected aberrations about 5 Hz. These parameters are mostly determined by the deformable mirror properties and multi-dither algorithm.
Clinical Nutrition Markers as Indicators of Colorectal Cancer (CRC) Disease Stage in a Public Hospital in New York City (2022)

The interrelationships between clinical nutrition markers and colorectal cancer (CRC), including the stage at disease onset, are not well defined. We evaluate nutritional indicators as a function of CRC disease stage. We seek to estimate the nutrition markers’ relative importance in the identification of advanced disease and poor prognosis. We utilized a retrospective cross-sectional database of CRC patients treated at two inner-city public hospitals from January 1, 2016, to June 1, 2021. The database includes demographic and routine clinical variables collected at the time of CRC diagnosis. Nutrition markers of interest included hemoglobin, albumin, and body mass index (BMI). Demographic and clinical variables of interest encompassed age, sex, race, smoking status, indication for colonoscopy (screening versus diagnostic), and continuity of care. Continuity of care was defined as having a primary care evaluation at least once within 5 years of a CRC diagnosis. Data were evaluated using one-way multivariate analysis of variance (MANOVA). Analysis was conducted on 259 patients (Gender: M = 119, F = 138; Race: White = 15.1%, African American/Black = 43.2%, Hispanic = 30.9%, Asian = 6.9%, Other = 4%). Data were divided into five cancer stages based upon CRC disease progression, with stages 0–2 representing cancer limited to the colonic wall, and stages 3–4 where the tumor extends beyond the colonic wall. MANOVA rejected hypothesis of equality of means between different stages (P = 0.0097). Individual one-way ANOVA for testing equality of means for different clinical stages with each outcome variable (adjusted for multiplicity of testing) produced significant results for albumin (P = 0.0099) and hemoglobin (P = 0.01), but not BMI (P = 0.06). When the mean of patients in stages 0–2 was compared to those in stages 3–4 (advanced versus non-advanced disease), significant differences were observed for albumin (P = 0.024) and hemoglobin (P = 0.017). Our results suggest that nutritional alterations are not observed in CRC patients until the tumor has advanced beyond the colonic wall (stages 3–4); our data were derived from a largely minority population. Future investigations should seek to replicate this work with more precise definitions of malnutrition, including more specific inflammatory markers besides albumin. None.
Social Structure from Multiple Networks. I. Blockmodels of Roles and Positions (1976)

Networks of several distinct types of social tie are aggregated by a dual model that partitions a population while simultaneously identifying patterns of relations. Concepts and algorithms are demonstrated in five case studies involving up to 100 persons and up to eight types of tie, over as many as 15 time periods. In each case the model identifies a concrete social structure. Role and position concepts are then identified and interpreted in terms of these new models of concrete social structure. Part II, to be published in the May issue of this Journal (Boorman and White 1976), will show how the operational meaning of role structures in small populations can be generated from the sociometric blockmodels of Part I.
Implementation and Evaluation of Secure Outsourcing Scheme for Secret Sharing Scheme on Cloud Storage Services (2014)

In this paper, we discuss a scheme for storing user's data into cloud servers using secret sharing scheme (SSS), which is a scheme for giving the availability and information-theoretically secure confidentiality to the stored data. Generally, system models using SSS perform processing of SSS at client terminals of users. Then, the size of data sending from a client terminal is n times of that of original user's data, where n is a parameter of SSS and larger than one. We focus on the usage that mobile devices are used as client terminals. The properties of mobile devices have low computational power and poor communication bandwidth compared with desktop PC and notebook PC. In these devices, the size of the sending data should be reduced in order not to waste the communication bandwidth. Hence, we present a scheme to securely outsource the processing of SSS on an agent server, which achieves the size of data sending by user's client terminal (mobile device) is as same as original user's data. In addition, our scheme gives computationally secure confidentiality to the temporally user's data on agent server, and does not require additional key management for recovering original user's data by combining a SSS using exclusive-OR operations and stream cipher. Moreover, we implement a prototype system, and evaluate the processing time and security of the proposed scheme.
Total Synthesis, NMR Solution Structure, and Binding Model of the Potent Histone Deacetylase Inhibitor FR235222 (2005)

An alternative route: The fungal metabolite FR235222, a potent inhibitor of mammalian histone deacetylase (HDAC), has been synthesized. Key steps are the preparation of unusual amino acids Ahoda and (2R,4S)-MePro. A 3D model for cyclopeptide inhibitor interaction with the HDAC active site (see picture) highlights the differences between the binding mode of small-molecule and cyclopeptide inhibitors. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z501995_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Nanoscience and Nanotechnology in Engineering (2010)

Introduction Physical and Biological Aspects of Nanoscience and Nanotechnology Nanoscale Fabrication and Characterisation Carbon Nanomaterials Nanostructured Materials Polymer Nanotechnology Nanocomposites Organic Electronics.
Measurement of the $$\mathrm{t}\overline{{\mathrm{t}}}$$ t t ¯ production cross section in the all-jets final state in pp collisions at $$\sqrt{s}=8$$ s = 8 $$\,\text {TeV}$$ TeV (2016)

The cross section for [Formula: see text] production in the all-jets final state is measured in pp collisions at a centre-of-mass energy of 8 [Formula: see text] at the LHC with the CMS detector, in data corresponding to an integrated luminosity of 18.4 [Formula: see text]. The inclusive cross section is found to be [Formula: see text] [Formula: see text]. The normalized differential cross sections are measured as a function of the top quark transverse momenta, [Formula: see text], and compared to predictions from quantum chromodynamics. The results are reported at detector, parton, and particle levels. In all cases, the measured top quark [Formula: see text] spectra are significantly softer than theoretical predictions.
Acoustic Improvement of High Pressure Fuel Pump (2013)

Recently, the need for noise reduction of high pressure fuel pump has been increasing due to rising environmental consciousness and improving comfort. Based on our acoustic investigation under idling condition, we identified that the solenoid noise and the compression noise are dominant on high pressure fuel pump. We have investigated the acoustic improvement technique of the solenoid noise for high pressure fuel pump and came to a conclusion that the solenoid noise can be reduced ca. 3dB by using optimization of control parameters and a reduced spring force. In this paper, we explain the concept of noise reduction, the control method and the extent of acoustic improvement.
Crucial role of synovial lining macrophages in the promotion of transforming growth factor β–mediated osteophyte formation (2004)

These findings indicate that macrophages are crucial intermediate factors in osteophyte formation induced by TGFbeta, probably by inducing other chondrogenic signals.
Portable standoff Raman and Mie-Rayleigh lidar for cloud, aerosol, and chemical monitoring (2003)

There is a need for portable, low-cost lidar systems that can be used for cloud, aerosols and chemical monitoring from a stand-off distance. At the University of Hawaii we have developed lidar systems based on a 12.7-cm diameter telescope and a 20 Hz frequency-doubled Nd:YAG laser source. For stand off Raman detection of organic liquid and vapors, and plastic explosives, we are using a 0.25-m HoloSpec f/2.2 spectrometer equipped with a gated intensified detector (PI Model I-MAX-1024-E). The samples of interest are excited with 532-nm laser light (35 mJ/pulse). The operational range of the Raman system is in 10's of meters and has been tested at distance of 66 m. This system can also be operated as a Raman lidar by using appropriate filters for atmospheric nitrogen, oxygen and other gaseous species of interest. The Mie-Rayleigh lidar system uses the same telescope and laser, but we have three (1064, 532 and 355-nm) wavelengths available for monitoring clouds and aerosols. A small Hamamatsu H6779 photomultiplier tube (PMT) located near the focal point of telescope detects 532-nm backscatter signal. An avalanche photodiode (APD, EG &amp; G C3095) detector equipped with a 2.5-cm diameter aspheric lens is used for detecting 1064-nm backscatter. The Mie-Rayleigh lidar has usable range of 60 - 4000 m. Results obtained with this system for marine aerosols and clouds are discussed.
Green-extraction of essential oil of the species Ruta chalepensis L.: gas chromatography-mass spectroscopy-infra red analysis and response surface methodology optimization (2019)

Abstract The objective of the present study was the optimization of the parameters affecting the hydrodistillation of Ruta chalepensis L. essential oil using response surface design type Box-Behnken. After an appropriate choice of three parameters, 15 experiments were performed leading to a mathematical second-degree model relating the response function (yield of essential oil) to parameters and allowing a good control of the extraction process. The realization of the experiments and data analysis was carried out by response surface methodology (RSM). A deduced second-order polynomial expression was used to determine the optimal conditions necessary to obtain a better essential oil yield. These optimized operating conditions were: a granulometry of 2 mm, a condensation-water flow rate of 3.4 mL/min and an extraction time of 204 min. Analysis of variance (ANOVA) indicates that the generated second-order polynomial model was highly significant with R 2 =0.9589 and P&lt;0.006. The gas chromatography-mass spectrometry analysis of essential oil extracted from the Ruta chalepensis L. aerial parts revealed the presence of 2-undecanone, 2-nonanone and 2-decanone as major components.
The structural gene for a phosphorus-repressible phosphate permease in Neurospora crassa can complement a mutation in positive regulatory gene nuc-1. (1988)

van+, a gene encoding a phosphorus-repressible phosphate permease, was isolated by its ability to complement nuc-1, a positive regulatory locus that normally regulates van+ expression. This was unexpected because the nuc-1 host already contained a resident van+ gene. Plasmids carrying van+ complemented a nuc-2 mutation as well. Probing of RNA from untransformed wild-type (nuc-1+) and constitutive (nuc-1c) strains by van+ probes indicated that levels of the van+ transcript were subject to control by nuc-1+. Probing of the same RNAs with a cosmid clone, containing approximately 15 kilobases of upstream and downstream DNA, revealed no other detectable phosphorus-regulated transcripts within this 40-kilobase region of the chromosome.
PYROLYSIS OF SUNNYSIDE (UTAH) TAR SAND: CHARACTERIZATION OF VOLATILE COMPOUND EVOLUTION (1989)

ABSTRACT Sunnyside (Utah) tar sand was subjected to programmed temperature pyrolysis and the volatile products were detected by tandem on-line mass spectrometry (MS/MS) in real time analyses. A heating rate of 4°C/min from room temperature to 900°C was employed. Evolution of hydrogen, light hydrocarbons, nitrogen-, sulfur-, and oxygen-containing compounds was monitored by MS or MS/MS detection. Evolution of volatile organic compounds occurred in two regimes: 1) low temperature (maximum evolution at 150 to 175°C), corresponding to entrained organics, and 2) high temperature (maximum evolution at 440 to 460°C), corresponding to cracking of large organic components. Alkanes and alkenes of two carbons and higher had temperatures of maximum evolution at approximately 440°C, and methane at approximately 474°C. Aromatic hydrocarbons had temperatures of maximum evolution slightly higher, at approximately 450° C. Some nitrogen-, sulfur-, and oxygen-'ccntaining compounds were also detected in the volatile products. Comparing the Sunnyside pyrolysis to the pyrolysis of other domestic tar sands indicated the following for hydrocarbon evolution: 1) the evolution of entrained organics relative to the total evolution was much less for Sunnyside tar sand, 2) the temperatures of maximum evolution of hydrocarbons due t o cracking reactions were slightly lower, and 3) the temperatures of maximum evolution for benzene and toluene are slightly higher than observed for other tar sands. In general, the noncondensible gases, H2, CO, and CO2, exhibited evolution associated with hydrocarbon cracking reactions, and high temperature evolution associated with mineral decomposition, the water-gas shift reaction, and gasification reactions. Pyrolysis yields were dominated by the evolution of carbon oxides and water. The CO2 primarily appeared t o cane from the decomposition of carbonate minerals. Compared t o other domestic tar sands, the gas evolution reflected more mineral decomposition character for Sunnyside tar sand.
Biomimetic nanoparticle technology for cardiovascular disease detection and treatment (2019)

Cardiovascular disease (CVD), which encompasses a number of conditions that can affect the heart and blood vessels, presents a major challenge for modern-day healthcare. Nearly one in three people has some form of CVD, with many suffering from multiple or intertwined conditions that can ultimately lead to traumatic events such as a heart attack or stroke. While the knowledge obtained in the past century regarding the cardiovascular system has paved the way for the development of life-prolonging drugs and treatment modalities, CVD remains one of the leading causes of death in developed countries. More recently, researchers have explored the application of nanotechnology to improve upon current clinical paradigms for the management of CVD. Nanoscale delivery systems have many advantages, including the ability to target diseased sites, improve drug bioavailability, and carry various functional payloads. In this review, we cover the different ways in which nanoparticle technology can be applied towards CVD diagnostics and treatments. The development of novel biomimetic platforms with enhanced functionalities is discussed in detail.
The giant protein HERC1 is recruited to aluminum fluoride‐induced actin‐rich surface protrusions in HeLa cells (2004)

HERC1 is a very large protein involved in membrane traffic through both its ability to bind clathrin and its guanine nucleotide exchange factor (GEF) activity over ARF and Rab family GTPases. Herein, we show that HERC1 is recruited onto actin-rich surface protrusions in ARF6-transfected HeLa cells upon aluminum fluoride (AlF(4)(-)) treatment. Moreover, the fact that HERC1 overexpression does not stimulate protrusion formation in the absence of AlF(4)(-), in conditions where ARNO does, indicates that HERC1 is not acting as an ARF6-GEF in this system, but that instead its recruitment takes place downstream of ARF6 activation. Finally, we suggest a phosphoinositide-binding mechanism whereby HERC1 may translocate to these protrusions.
Molecular Engineering of Near Infrared Absorbing Thienopyrazine Double Donor Double Acceptor Organic Dyes for Dye-Sensitized Solar Cells (2017)

The thienopyrazine (TPz) building block allows for NIR photon absorption in dye-sensitized solar cells (DSCs) when used as a π-bridge. We synthesized and characterized 7 organic sensitizers employing thienopyrazine (TPz) as a π-bridge in a double donor, double acceptor organic dye design. Donor groups are varied based on electron donating strength and sterics at the donor-π bridge bond with the acceptor groups varied as either carboxylic acids or benzoic acids on the π-bridge. This dye design was found to be remarkably tunable with solution absorption onsets ranging from 750 to near 1000 nm. Interestingly, the solution absorption measurements do not accurately approximate the dye absorption on TiO<sub>2</sub> films with up to a 250 nm blue-shift of the dye absorption onset on TiO<sub>2</sub>. This shift in absorption and the effect on electron transfer properties is investigated via computational analysis, time-correlated single photon counting studies, and transient absorption spectroscopy. Structure-performance relationships were analyzed for the dyes in DSC devices with the highest performance observed at 17.6 mA/cm<sup>2</sup> of photocurrent and 7.5% PCE for a cosensitized device with a panchromatic IPCE onset of 800 nm.