gebhart/patrepeval huggingface dataset:
A neural network agent based approach to activity detection in AmI environments (2005)

Many countries are facing the problem of caring economically for their ageing population. One approach to this is the development of environments which possess ambient intelligence that will provide care for older people while assisting them with their everyday life activities. One function that is required in care provision is spotting abnormal behaviours as this might be an indicator of a problem requiring attention from a carer. Agent technology can be employed to detect abnormalities by first learning a normal set of personal behaviours and then detecting deviations from these. This paper presents a novel connectionist embedded agent architecture that combines the use of unobtrusive and relatively simple sensors and employs a constructive algorithm with temporal capabilities which is able to recognize different high level activities (such as “sleeping”, “working at computer”, “eating”), and identify abnormal behaviours. The network is trained in an online mode, and is able to adapt and expand itself as new data are made available over time or it can add new output nodes to represent new classes or accommodate the abnormal instances. The developed connectionist approach is not computationally demanding and hence it can be integrated into the limited processor-power embedded computing platforms used in intelligent domestic environments.
Enhancement of bleomycin activity by 3-aminobenzamide, a poly (ADP-ribose) synthesis inhibitor, in vitro and in vivo. (1988)

A series of poly (ADP-ribose) synthesis inhibitors was evaluated for their ability to potentiate the cytotoxicity of bleomycin compared with their inhibition of poly(ADP-ribose) synthesis in L1210 cultured cells. Theophylline, nicotinamide, 3-aminobenzamide and thymidine inhibited 70 to 80% of poly(ADP-ribose) synthesis in L1210 cells. The degree of inhibition of poly(ADP-ribose) synthesis by these inhibitors corresponded in general with their potentiating ability of bleomycin cytotoxicity. Among these inhibitors, 3-aminobenzamide significantly potentiated the cytotoxic activity of bleomycin (3.6 fold), but it could not potentiate the cytotoxic activity of other antitumor agents, including nitrosourea and Cis-DDP, in L1210 cells in vitro. Treatment of Ehrlich ascites tumor bearing mice with bleomycin and 3-aminobenzamide produced a synergistic effect. 6-Aminonicotinamide also potentiated the antitumor activity of bleomycin against Ehrlich ascites tumor.
3D Regional Velocity Modeling (2014)

Summary Building a realistic and accurate regional velocity model at the scale of a basin is only possible by integrating seismic velocity data. Traditionally the integration of the seismic velocity data into a velocity model is made by a layer cake approach. This is a quite incomplete integration as the approach stacks, layer by layer, the vertical structuration of the seismic velocity data. At the scale of a basin, a fully 3D integration of the seismic velocity data sets, coupled with previous qualification and merge steps, leads to the generation of a 3D continuous velocity model. That fully 3D approach, possible thanks to advanced geostatistical techniques, has been applied on several basins. The observed depth uncertainty attached to the velocity models is on average about +/−70m (error far from the wells, expressed in terms of 2 × standard deviation of the errors distribution).
Presentazione alle parti sociali del d.d.l. sullo statuto dei lavori. Miscellanea (2011)

Si tratta dell'osservatorio di legislazione che i due autori curano per la parte terza della rivista.
Adaptive parametric spectral estimation with Kalman smoothing for online early seizure detection (2013)

Tracking spectral changes in neural signals, such as local field potentials (LFPs) and scalp or intracranial electroencephalograms (EEG, iEEG), is an important problem in early detection and prediction of seizures. Most approaches have focused on either parametric or nonparametric spectral estimation methods based on moving time windows. Here, we explore an adaptive (time-varying) parametric ARMA approach for tracking spectral changes in neural signals based on the fixed-interval Kalman smoother. We apply the method to seizure detection based on spectral features of intracortical LFPs recorded from a person with pharmacologically intractable focal epilepsy. We also devise and test an approach for real-time tracking of spectra based on the adaptive parametric method with the fixed-interval Kalman smoother. The order of ARMA models is determined via the AIC computed in moving time windows. We quantitatively demonstrate the advantages of using the adaptive parametric estimation method in seizure detection over nonparametric alternatives based exclusively on moving time windows. Overall, the adaptive parametric approach significantly improves the statistical separability of interictal and ictal epochs.
Domain Generalization in Biosignal Classification (2020)

To our best knowledge, this is the first study that investigates domain generalization for biosignal data. Our proposed learning strategy can be used to effectively learn domain-relevant features while being aware of the class differences in the data.
A generic processing structure decomposing the beamforming process of 2-D and 3-D arrays of sensors into sub-sets of coherent process (2003)

This paper details the development of a generic beamforming structures for multidimensional sensor arrays with passive and active capabilities. A new approach of the implementation of conventional beamforming for planar, cylindrical and spherical arrays is proposed. This approach is based on decomposing the 2-D and 3-D beamforming process into sets of line and/or circular array beamformers which lead to an efficient implementation. Furthermore, this new approach makes the incorporation of adaptive schemes feasible.
Novel Resuscitation Strategy for Pulmonary Contusion after Severe Chest Trauma (2003)

Hextend reduced the volume for initial resuscitation, which may offer logistical advantages in prehospital field conditions or whenever there is limited medical resources or prolonged transport times; ATL-146e improved early cardiac performance without causing hypotension or bradycardia; when administered 25 to 30 minutes after injury, neither Hextend nor ATL-146e altered inflammatory changes in pulmonary Mphis or infiltrating PMNs; and further studies are needed to determine whether these short-term benefits correlate with long-term outcome.
Hole lifetimes in [001] uniaxial stressed GaAs (1993)

The time-resolved photoluminescence (PL) spectra from n-type GaAs is nonexponential and is characterized by two decay constants (A and B). If the bimolecular recombination coefficient B is zero, the PL spectra have the familiar exponential time dependence (and are characterized by the recombination decay constant A). Application of uniaxial stress along [001] to the n-type GaAs sample causes the recombination decay constant A to increase, in agreement with the stress dependence of the matrix elements. The bimolecular recombination coefficient B is found to be stress independent. An increase in the density of the photogenerated holes ${\mathit{P}}_{0}$ as a function of stress is also observed. This is attributed to the stress dependence of the effective mass which changes the absorption coefficient. The stress dependence of the recombination decay constants A and b=${\mathit{BP}}_{0}$ determines the stress dependence of the effective lifetimes of the light hole (parallel to the stress) in the n-type GaAs.
Modélisation chimique de la réaction alcali-silice: prise en compte de l'influence de la distribution granulaire réactive (2004)

ABSTRACT Nowadays, knowledge about ASR mechanisms is good enough to prevent new cases. Nevertheless a numerical tool seems necessary for all affected structures. This article deals with a new modelling based on the description of alkalis and calcium transport within concrete. It takes into account the effect of the size and distribution of reactive aggregates. Results from an experimental campaign and corresponding numerical simulations are presented and compared.
Different populations of rheumatoid adherent cells mediate activation versus suppression of t lymphocyte proliferation (1985)

Adherent cells from synovial tissue of rheumatoid arthritis patients were fractionated on Percoll density gradients and analyzed to determine phenotypes, effects on allogeneic T lymphocyte proliferation, and production of prostaglandin E2 (PGE2). Cells expressing HLA-DR predominated in all fractions, and esterase-positive cells were enriched in light fractions. Heavy cells were potent stimulators in the mixed lymphocyte reaction and produced little PGE2, whereas light cells suppressed the mixed lymphocyte reaction and produced a large quantity of PGE2. These results suggest that macrophage-like synovial cells that suppress T helper lymphocyte activity are generated secondary to synovial lymphocyte activation in rheumatoid arthritis.
ChemInform Abstract: From Epiraikovenal, an Instrumental Niche‐Exploitation Sesquiterpenoid of Some Strains of the Marine Ciliated Protist Euplotes raikovi, to an Unusual Intramolecular tele‐Dienone‐Olefin (2 + 2) Photocycloaddition. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Initial subjective reward: single-exposure conditioned place preference to alcohol in mice (2014)

Most adults consume alcohol with relative impunity, but about 10-20% of users persist (or progress) in their consumption, despite mounting and serious repercussions. Identifying at-risk individuals before neuroadaptative changes associated with chronic use become well ingrained is thus a key step in mitigating and preventing the end stage disease and its devastating impacts. Explaining liability has been impeded, in part, by the absence of animal models for assessing initial sensitivity to the drug's reinforcing properties, an important endophenotype in the trajectory toward excessive drinking. Here we assess the initial rewarding effects of the drug in a novel application of the conditioned place preference paradigm. In contrast to previous studies that have all employed repeated drug administration, we demonstrated a robust preference for a context paired with a single exposure to 1.5 g/kg EtOH in male and female subjects of three strains. This model validates an assay of initial sensitivity to the subjective rewarding effects of alcohol, a widely used drug with multifarious impacts on both brain and society, and provides a new tool for theory-driven endophenotypic pharmacogenetic approaches to understanding and treating addiction.
Infrared magneto-optical and photoluminescence studies of the electronic properties of In(As,Sb) strained-layer superlattices (1991)

Long-wavelength magnetotransmission and photoluminescence measurements were performed on ${\mathrm{InAs}}_{0.13}$${\mathrm{Sb}}_{0.87}$/InSb strained-layer superlattices (SLS's). The energies and reduced effective masses of several interband optical transitions were obtained from these experiments. SLS's with different layer thicknesses produced self-consistent results. With these data, the type-II band offset and band-edge strain-shift parameters were accurately determined. Consistent with a type-II offset, an extremely small, in-plane effective-mass hole ground state was observed, thus proving that the hole quantum well is located in the biaxially compressed, InSb layer. Nonparabolicity, suggesting valence-band anticrossing, was also observed.
Team-level properties for haptic human-swarm interactions (2015)

This paper explores how haptic interfaces should be designed to enable effective human-swarm interactions. When a single operator is interacting with a team of mobile robots, there are certain properties of the team that may help the operator complete the task at hand if these properties were fed back via haptics. However, not all team-level properties may be particularly well-suited for haptic feedback. In this paper, characteristics that make a property of a multi-agent system appropriate for haptic feedback are defined. The focus here is on leader-follower networks, in which one robot, the so-called leader, is controlled via an operator with a haptic device, whereas the remaining robots, the so-called followers, are tasked with maintaining distances between one another. Multi-agent manipulability, a property which describes how effective the leader is at controlling the movement of the followers, is proposed as one such appropriate property for haptic feedback in a human-swarm interaction scenario. Manipulability feedback is implemented using a PHANTOM Omni haptic joystick and experiments in which a team of mobile robots is controlled via a human operator with access to this feedback show that this is viable in practice.
Efficient Synthesis of (P-Chirogenic) o-Boronated Phosphines from sec-Phosphine Boranes (2015)

An efficient synthesis of boronated phosphines with an o-phenylene-bridge prepared from sec-phosphine boranes and using benzyne chemistry is reported. Successive reactions of sec-phosphine boranes with n-BuLi and 1,2-dibromobenzene, and then with boron reagents, afford the o-boronatophenylphosphine derivatives in 71% yields. The use of P-chirogenic sec-phosphine boranes leads to the free boronated phosphines with retention of configuration at the P-center after decomplexation. The reaction of P-chirogenic o-boronatophenylphosphine with KHF2 affords the corresponding trifluoroborated phosphine with ee >98%.
Abstract #LB-160: CXCR4 antagonist as a sensitizing agent for anti-tumor therapies in disseminated lymphoma models (2009)

AACR Annual Meeting-- Apr 18-22, 2009; Denver, CO

CXCR4 is a chemokine receptor frequently over-expressed on hematological cancers and solid tumors. CXCR4 plays an important role in cancer metastasis, regulation of stem cell trafficking and neovascularization. The human B-lymphoma cell lines Raji and B-104 express high levels of human CXCR4 as well as CD52 and CD20, the targets of the monoclonal antibodies Campath and Rituxan, respectively. We hypothesized that the small molecule CXCR4 antagonists AMD3465 and AMD3100 could compromise tumor cell growth by inhibiting the survival signals delivered through the interaction of CXCR4 and SDF-1 in the tumor stroma and increase the susceptibility of the tumor cells to the cytotoxic effects of monoclonal antibody therapy. Lymphoma cells were seeded by intravenous injection and tumor-bearing mice were treated with multiple injections of AMD3465 or AMD3100. Interestingly, treatment with AMD3465 as a single agent was sufficient to increase survival of the animals compared to untreated controls. In addition, the combination of AMD3465 and Campath showed a synergistic effect with a prolongation of survival greater than that obtained with either agent alone. Similarly, combination of the CXCR4 antagonist AMD3100 and Rituxan also resulted in a significantly prolonged survival compared to either agent alone. The impact of treatment on tumor burden was confirmed by Xenogen imaging. These results suggest that there is a potential role for CXCR4 antagonists in combination with a B-cell targeted therapy in the treatment of B-cell malignancies.

Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr LB-160.
Observation of impurity effects on the nucleation of arsenic precipitates in GaAs (1993)

The precipitation of arsenic in low temperature GaAs uniformly doped with Si and Be has been studied by transmission electron microscopy. Following an in situ anneal at 600 °C, precipitate size and density is found to be strongly dependent on the dopant type. Impurities at the epilayer/substrate interface lead to heterogeneous nucleation of precipitates. Although precipitates were observed to nucleate heterogeneously at threading dislocations, the precipitates predominantly form homogeneously. These results are consistent with the general theory of precipitation in solids.
Tuning the Bandgap and Cytotoxicity of ZnO by Tailoring the Nanostructures (2014)

Tuning the bandgap and cytotoxicity of ZnO nanoparticles (NPs) is very important, not only for customizing their optoelectronic and biomedical applications, but also for their cytotoxicity assay and safe usage. A unique soft‐template of polyvinylpyrrolidone has been developed here to realize a rapid room‐temperature neutral synthesis of ZnO with controlled nanostructures for tuning the bandgap and cytotoxicity of ZnO. By simply changing the reagent stoichiometry and the soft‐template shape, high‐purity ZnO rods, tripods, tubes, and unique T‐like tubes with tunable size, surface composition/charge, bandgap, and cytotoxicity are obtained. It has been revealed that the ZnO bandgap can be remarkably reduced by introducing the surface nonstoichiometry; and the ZnO‐induced cytotoxicity can be tuned by the size, shape, surface charge/composition, and bandgap of ZnO NPs at different degrees. Significantly, both the photochemistry reaction and the reactive oxygen species induced by ZnO NPs are not necessary for the ZnO‐induced cytotoxicity.
Treatment of Hepatocellular Carcinoma Associated with Cirrhosis in the Era of Liver Transplantation (1998)

The efficacy of liver transplantation for hepatocellular carcinoma has been proven mainly in patients with advanced cirrhosis and small lesions. Future studies may clarify the role of approaches combining neoadjuvant chemotherapy with transplantation for large (stage III) tumors.
3D flexible multi-probe setups for MIMO OTA testing (2017)

This paper presents a method to construct 3D flexible multi-probe setups for MIMO OTA testing. The optimal OTA probe locations are determined on the surface of a whole sphere in 3D flexible multi-probe setups proposed. The proposed method applies both genetic algorithm and convex optimization to 3D flexible multi-probe setups, which obtains better emulation accuracy of the 3D channel spatial correlation at the receiver side. Simulation results show that the proposed 3D flexible multi-probe setups with a smaller number of OTA probes can achieve more accurate 3D spatial correlation accuracy within the test volume for MIMO OTA testing.
Percutaneous aortic valve replacement: valvuloplasty studies in vitro (2010)

This study demonstrated a large amount of calcific particles after valvuloplasty with a consequently high risk for coronary embolic events in case of highly calcified aortic valves. In times of valvuloplasty rediscovering as part of transcatheter valve implantation, the risk of embolization should be taken into consideration and filtering techniques have to be developed.
Numerical Modeling of Thermal EOR: Comprehensive Coupling of an AMR-Based Model of Thermal Fluid Flow and Geomechanics (2012)

Modeling Steam Assisted Gravity Drainage (SAGD) can involve significant CPU (Central Processing Unit) time when both thermal fluid flow and geomechanics are coupled in order to take into account variations of permeability and porosity inside the reservoir due to stress changes. Here, a numerical procedure that performs thermo-hydro-mechanical simulations, in an efficient way, is presented. This procedure relies on an iterative coupling between a thermal reservoir simulator based on a finite volume method and a geomechanical one based on a finite element method. A strong feature of this procedure is that it allows handling the case when the reservoir simulations are performed using Adaptive Mesh Refinements (AMR). It thus provides an accurate description of the steam front evolution and allows taking geomechanical effects into account without performing the geomechanical simulations on a refined mesh. The efficiency of this coupling procedure is illustrated on a synthetic but realistic SAGD test case.
Changes in GDP binding to brown adipose tissue mitochondria and the uncoupling protein (1988)

Incubation in vitro of brown adipose tissue (BAT) mitochondria with divalent cations, spermine, or alkaline phosphatase led to a marked increase in the binding of [3H]GDP. The effect of Mg2+ appeared to be the most specific and led to the largest increase in GDP binding. A simplified method was developed for measuring GDP binding to purified uncoupling protein from rat BAT mitochondria. Application of this method indicates that uncoupling protein from cold-acclimated rats binds twice as much GDP as uncoupling protein from cold-acclimated rats that were briefly returned to thermoneutrality, paralleling changes in GDP binding to the mitochondria. Incubation of BAT mitochondria with Mg2+ led to a smaller increase in GDP binding to the subsequently purified uncoupling protein, suggesting that divalent cations may somehow participate in the regulation of the activity of the uncoupling protein.
Metal alkoxides and β‐diketonates as precursors for oxide and non‐oxide thin films (1992)

Abstract Single‐components or multicomponent oxide thin films are of interest for electronic and opto‐electronic devices, optical applications, catalysis, corrosion protection etc. Their preparation by chemical routes is based on the hydrolytic (sol‐gel process) or pyrolytic (MOCVD) conversion of precursors. Derivatives having MO bonds, namely metal alkoxides, carboxylates or β‐diketonates, are the most common sources of metal oxides. The properties of alkoxides are appropriate for sol‐gel as well as MOCVD applications, whilst the limited hydrolytic susceptibility but good volatility of β‐diketonates is most convenient for MOCVD purposes. The low temperature and flexibility of sol‐gel routes, and the presence of residual OH groups in the final films, are favorable for the encapsulation of organic or organometallic derivatives, the anchoring of enzymes and in general for the development of functional and composite coatings. The facile formation of heterometallic alkoxides is also attractive for the development of coatings based on multimetallic formulations. MOCVD is favorable for the buildup of heterostructures and epitaxial layers. Although metal alkoxides and β‐diketonates are usually oxide precursors, nitride or sulfide films can be obtained by reacting with the appropriate reagents. Fluorinated ligands enhance volatility but often result in the formation of metal fluorides.
Gas Chromatography (2017)

The porous polymer stationary phases which for many years have been available in packed gas chromatography (GC) columns have only recently become available as a coated capillary. These cross-linked porous polymer columns are produced by copolymerizing styrene and divinylbenzene. The high-speed columns are generally used where highest efficiencies and speeds are required, such as GC-mass spectrometry (GC-MS) applications where reduced run times can increase source and electron multiplier lifetimes. Atomic spectroscopy as a means of detection in GC is becoming popular because it offers the possible selective detection of variety of metals, organometallic compounds, and selected elements. The basic approaches to GC-atomic spectroscopy detection include plasma emission, atomic absorption, and fluorescence. A statistical evaluation of methods using headspace GC for determination of ethylene oxide in plastic surgical items was performed by M. Kaye and T. Nevell. Two methods were evaluated: an external standard method using ethylene oxide in air, and an internal standard method using dilute aqueous solution with acetone.