gebhart/patrepeval huggingface dataset:
Human and spatial dimensions of retail density: Revisiting the role of perceived control (2008)

Abstract Previous research in environmental psychology and consumer behavior has demonstrated mostly negative effects of human density on consumer experience in retail settings. The effects of spatial density, however, have received scant attention. Results from previous studies show that retail density affects shoppers' emotional and behavioral responses through perceived control.Work in social psychology, however, indicates that there are differences in the extent to which people strive for control, suggesting that having control in retail settings may be more important to some consumers than to others. In the experimental study reported in this paper, the effects of both forms of retail density were studied as a function of consumers' desire for control. Results indicate that the effects of human and spatial density vary with consumers' desire for control. Theoretical and managerial implications are discussed. © 2008 Wiley Periodicals, Inc.
Abrogation of the beneficial blood transfusion effect in dogs by splenectomy (1984)

Abstract The role of the spleen in the manifestation of the transfusion phenomenon was studied in beagle dogs. Beagles were transfused 3 times with 100 ml blood from different mismatched mongrel dogs, at 4, 3, and 2 weeks before mongrel kidney transplantation or splenectomy. Seven transfused dogs were splenectomized 1 week before transplantation, 9 transfused animals were not splenectomized, and a group of 9 kidney allografted controls was neither transfused nor splenectomized. All recipients were given postoperative immunosuppression, which consisted of azathioprine and prednisolone. As with earlier demonstrations it was found that 3 pretransplant blood transfusions in the nonsplenectomized group led to a significant prolongation of kidney graft survival. All transfused animals survived for more than 3 weeks, a period in which more than 50% of the kidneys in the control group were rejected. Four out of 9 transfused dogs became long‐term survivors. In the transfused‐splenectomized group, 70% of the recipients rejected their kidney acutely within 3 weeks, and only one animal became a long‐term survivor. The absence of a transfusion effect in most of the splenectomized dogs suggests that, under the experimental conditions employed, the spleen plays a crucial role for the induction and manifestation of the transfusion phenomenon .
Enteroplication for the prevention of intussusception recurrence in dogs: 31 cases (1978–1992) (1994)

Medical records of 31 dogs that had undergone surgery for correction of intussusception during a 14-year period were reviewed. Enteroplication was performed on 9 dogs during the initial surgery, and intussusception did not recur in any of these dogs. Intussusceptions recurred in 6 of 22 dogs without enteroplication. Five of these dogs had undergone resection of the primary lesion and anastomosis and 1 dog had undergone manual reduction of the intussusception. Intussusceptions recurred proximal to the initial lesion in 4 dogs, and at the same site in 2 dogs. Enteroplication was performed in 4 dogs following surgical correction of recurrence of an intussusception, and further recurrences were not seen in any of these dogs. Enteroplication did not cause any apparent adverse effects and decreased the probability of recurrence of intussusception in these dogs.
Flexure Hinge Grating Suspension (1974)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text William H. Fletcher, John S. Rayside, and William J. Wiley, "Flexure Hinge Grating Suspension," Appl. Opt. 13, 734_1-736 (1974) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Immunomodulators and microRNAs as neurorestorative therapy for ischemic stroke (2017)

Most of all strokes are ischemic due to occlusion of a vessel, and comprise two main types, thrombotic and embolic. Inflammation and immune response play an important role in the outcome of ischemic stroke. Pharmaceutical and cell-based therapies with immunomodulatory properties could be of benefit in treating ischemic stroke. Possible changes in microRNAs brought about by immunomodulatory treatments may be important. The pharmaceutical studies described in this review have identified several differentially regulated miRNAs associated with disregulation of mRNA targets or the upregulation of several neuroprotective genes, thereby highlighting the potential neuroprotective roles of specific miRNAs such as miR-762, -1892, -200a, -145. MiR-124, -711, -145 are the strongly associated miRNAs predicted to mediate anti-inflammatory pathways and microglia/macrophage M2-like activation phenotype. The cell-based therapy studies reviewed have mainly utilized mesenchymal stem cells or human umbilical cord blood cells and shown to improve functional and neurological outcomes in stroke animals. MiR-145 and miR-133b were implicated in nerve cell remodeling and functional recovery after stroke. Human umbilical cord blood cells decreased proinflammatory factors and promoted M2 macrophage polarization in stroke diabetic animals.
FREQUENCY DOMAIN CONDITIONS FOR THE EXISTENCE OF ALMOST PERIODIC SOLUTIONS IN EVOLUTIONARY VARIATIONAL INEQUALITIES (2004)

Evolutionary variational inequalities are considered as control systems in a general rigged Hilbert space structure. Sufficient frequency domain conditions for boundedness and the existence of periodic and almost periodic solutions are derived. As an example a boundary control problem with periodic excitation function is considered.
THE VISUAL DISCRIMINATION OF INTENSITY AND THE WEBER-FECHNER LAW (1924)

1. A study of the historical development of the Weber-Fechner law shows that it fails to describe intensity perception; first, because it is based on observations which do not record intensity discrimination accurately, and second, because it omits the essentially discontinuous nature of the recognition of intensity differences. 2. There is presented a series of data, assembled from various sources, which proves that in the visual discrimination of intensity the threshold difference DeltaI bears no constant relation to the intensity I. The evidence shows unequivocally that as the intensity rises, the ratio See PDF for Equation first decreases and then increases. 3. The data are then subjected to analysis in terms of a photochemical system already proposed for the visual activity of the rods and cones. It is found that for the retinal elements to discriminate between one intensity and the next perceptible one, the transition from one to the other must involve the decomposition of a constant amount of photosensitive material. 4. The magnitude of this unitary increment in the quantity of photochemical action is greater for the rods than for the cones. Therefore, below a certain critical illumination-the cone threshold-intensity discrimination is controlled by the rods alone, but above this point it is determined by the cones alone. 5. The unitary increments in retinal photochemical action may be interpreted as being recorded by each rod and cone; or as conditioning the variability of the retinal cells so that each increment involves a constant increase in the number of active elements; or as a combination of the two interpretations. 6. Comparison with critical data of such diverse nature as dark adaptation, absolute thresholds, and visual acuity shows that the analysis is consistent with well established facts of vision.
A jump-target identification method for multi-architecture static binary translation (2016)

Static binary translation is a technique that allows an executable program for a given architecture to be translated into a different one, with a reduced overhead compared to emulators and dynamic binary translators. The main downside of the static approach lies in the absence of runtime information, which is available in other solutions. In particular, one of the key issues consists in the identification of data and code in the program, and, more specifically, in the detection of basic block start addresses (jump targets). The presence of indirect jump instructions whose target is not immediately evident, in particular due to C switch statements, makes the recovery of jump targets a challenging task.
Using optical forces for the characterization of biological cell activities (2006)

Optical forces successfully manipulate biological cells and measure small forces such as molecular binding forces. This paper focuses on the use of optical forces for the direct characterization of various activities of biological cells
Serum levels of galactose-deficient immunoglobulin (Ig) A1 and related immune complex are associated with disease activity of IgA nephropathy (2014)

Disease activity of IgAN assessed by hematuria and proteinuria correlated with serum levels and changes of Gd-IgA1 and IgA/IgG-IC. These new noninvasive disease activity markers can be useful for future activity scoring system and guiding therapeutic approaches.
A Waveguide Impedance Meter for the Automatic Display of Complex Reflection Coefficient (1955)

A waveguide impedance meter has been developed, comprising some specially designed components and some components previously designed for other applications. When this circuit is used in conjunction with the X-band rapid sweep oscillator and suitable display and control circuits, the impedance focus of a waveguide component is automatically and rapidly measured and oscilIographically displayed in the reflection coefficient plane. A waveguide component having a 11/4-inch X 5/8-inch (large X-band) waveguide input port can be continuously measured throughout the frequency range extending from 8.5 to 9.6 kmc (12 per cent X-band). The bandwidth of the system is limited by the design bandwidth of the waveguide components. The plane of the impedance measurement may be referred to a plane internal to or external to the input port of the component under test. An expanded portion of the reflection coefficient plane may be displayed on the crt when small reflections are measured. The measurements of several representative impedances by the waveguide circuit were compared with slotted line measurements of these same components. For measurements of large reflections, standard /spl infin/ db swr full scale display, the maximum observed errors of the magnitude and phase of the reflection coefficient as measured by the waveguide circuit were 10 per cent and 5 degrees respectively. These maximum errors occurred for measurements performed at the ends of the 12 per cent frequency band. The average errors of the magnitude and phase of the reflection coefficient were 2.5 per cent and 2 degrees respectively. For measurements of small reflections, with the crt display of the reflection coefficient plane expanded to 6 db swr full scale, the maximum observed deviation of the waveguide circuit measurements from slotted line measurements was 0.5 db swr, and the average deviation was 0.2 db swr. The maximum errors again occurred at the ends of the 12 per cent frequency band.
Use of 5-Bromo-4-Chloro-3-Indolyl-α- d - N -Acetylneuraminic Acid in a Novel Spot Test To Identify Sialidase Activity in Vaginal Swabs from Women with Bacterial Vaginosis (2000)

The validity of measuring vaginal sialidase activity to identify bacterial vaginosis (BV) was determined by using 5-bromo-4-chloro-3-indolyl-alpha-D-N-acetylneuraminic acid in a near-patient test. The sensitivity and specificity of the test for prediction of BV were 95.6 and 96.3%, respectively. Positive and negative predictive values were 95.6 and 96.3%, respectively. This test may be an alternative to Gram staining.
Highly selective electrochemical detection of dopamine using interdigitated array electrodes modified with nafion/polyester lonomer layered film (1994)

Abstract The highly selective electrochemical detection of dopamine has been developed using an interdigitated microarray (IDA) electrode coated with Nafion and polyester ionomer (Kodak AQ29D) layered films. Because high redox cycling of dopamine can be maintained in the AQ29D bottom layer, a low detection limit of 50 nmol/dm 3 is obtained. Since the upper Nafion laybr prevents L ‐ascorbic acid from diffusing into the AQ29D layer, the acid concentration in this layer rapidly decreases when potentiostating one IDA electrode (anode) above and the other (cathode) below the redox potential of dopamine. This is because L ‐ascorbic acid molecules in the AQ29D layer are removed quickly by the electrochemical or electrocatalytic oxidation at the anode. On the other hand, almost all of the oxidized dopamine molecules are reduced at the cathode, which maintains a constant dopamine concentration in the film during measurement. After the potential step, the influence of L ‐ascorbic acid is almost completely eliminated within a few seconds due to the reduction in acid concentration in the modified layer. As a result, dopamine can be detected quantitatively at the cathode in the presence of 100‐fold excess of L ‐ascorbic acid.
The Stereospecificity of Secondary Alcohol Dehydrogenase from Thermoanaerobacter ethanolicus Is Partially Determined by Active Site Water (2000)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTThe Stereospecificity of Secondary Alcohol Dehydrogenase from Thermoanaerobacter ethanolicus Is Partially Determined by Active Site WaterChristian Heiss, Maris Laivenieks, J. Gregory Zeikus, and Robert S. PhillipsView Author Information Department of Chemistry, Department of Biochemistry and Molecular Biology, and Center for Metalloenzyme Studies University of Georgia, Athens, Georgia 30602-2556 Department of Biochemistry, Michigan State University East Lansing, Michigan 48824-1319 Cite this: J. Am. Chem. Soc. 2001, 123, 2, 345–346Publication Date (Web):December 21, 2000Publication History Received5 September 2000Published online21 December 2000Published inissue 1 January 2001https://doi.org/10.1021/ja005575aCopyright © 2001 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views281Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (26 KB) Get e-AlertsSUBJECTS:Alcohols,Alkyls,Genetics,Peptides and proteins,Stereospecificity Get e-Alerts
Autologous Bone Marrow Mononuclear Cell-Based Tissue Engineered Heart Valves: First Experiences with a One-step Intervention in Primates (2012)

Abstract A living heart valve with regeneration capacity based on autologous cells and minimally invasive implantation technology would represent a substantial improvement upon contemporary heart valve prostheses. This study investigates the feasibility of injectable, marrow stromal cell-based, autologous, living tissue engineered heart valves (TEHV) generated and implanted in a one-step intervention in non-human primates. Trileaflet heart valves were fabricated from non-woven biodegradable synthetic composite scaffolds and integrated into self-expanding nitinol stents. During the same intervention autologous bone marrow-derived mononuclear cells were harvested, seeded onto the scaffold matrix, and implanted transapically as pulmonary valve replacements into non-human primates (n=6). The transapical implantations were successful in all animals and the overall procedure time from cell harvest to TEHV implantation was 118±17 min. In vivo functionality assessed by echocardiography revealed preserved valvular structures and adequate functionality up to 4 weeks post implantation. Substantial cellular remodeling and in-growth into the scaffold materials resulted in layered, endothelialized tissues as visualized by histology and immunohistochemistry. Biomechanical analysis showed non-linear stress-strain curves of the leaflets, indicating replacement of the initial biodegradable matrix by living tissue. Here we provide a novel concept demonstrating that heart valve tissue engineering based on a minimally invasive technique for both cell harvest and valve delivery as a one-step intervention is feasible in non-human primates. This innovative approach may overcome the limitations of contemporary surgical and interventional bioprosthetic heart valve prostheses.
Effects of Encapsulation in Sol−Gel Silica Glass on Esterase Activity, Conformational Stability, and Unfolding of Bovine Carbonic Anhydrase II (1999)

Bovine carbonic anhydrase II retains its overall conformation when encapsulated in silica monoliths by the sol−gel method. Upon gradual heating the enzyme in solution precipitates at 64 °C, whereas the encapsulated enzyme does not; it unfolds, with the nominal melting temperature of 51 ± 3 °C. Even at 74.0 °C, the encapsulated enzyme is only ∼77% unfolded, but it does not refold upon cooling. Upon treatment with guanidinium chloride, the degree of enzyme unfolding is 100% in solution but only ∼83% within the silica matrix. Again, the enzyme does not refold upon removal of the denaturing agent from the glass. The glass matrix constrains the motions of the encapsulated protein molecules and prevents both their full unfolding and refolding. The former may be taken for “stabilization”, the later for “destabilization” of the native conformation. Evidently, the effect of the glass on the encapsulated protein cannot be described in these general terms. The encapsulated enzyme obeys the Michaelis−Menten kinetic law as it catalyzes hydrolysis of p-nitrophenyl acetate. The apparent Michaelis constant (K‘M) is practically the same in the glass and in solution, but the apparent turnover number (k‘cat) and specific activity for the encapsulated enzyme are only 1−2% of these values for the enzyme in solution. Because the substrate diffuses slowly into silica pores, most of the catalysis is due to the enzyme embedded near the surfaces of the glass monolith. Effect of encapsulation on structure and activity of proteins should be studied in quantitative detail before protein-doped glasses can be used as reliable biosensors, heterogeneous catalysts, and composite biomaterials.
High-efficiency multiple-output DC-DC conversion for low-voltage systems (2000)

This versatile power converter controller provides dual outputs at a fixed switching frequency and can regulate either output voltage or target system delay (using an external L-C filter). In the voltage regulation mode, the output voltage is monitored with an analog-digital (A/D) converter, and the feedback compensation network is implemented digitally. The generation of the pulsewidth modulation (PWM) signal is done with a hybrid delay line/counter approach, which saves power and area relative to previous implementations. Power devices are included on chip to create the two independently regulated output PWM signals. The key features of this design are its low-power dissipation, reconfigurability, use of either delay or voltage feedback, and multiple outputs.
Fast Design of Reliable, Flexible and High-Speed AWGN architectures with High Level Synthesis (2018)

International audience
Transcriptome analysis of leaf and root of rice seedling to acute dehydration (2013)

Leaf and root tissues shared some common gene expression during stress, with the purpose of enhancing protective systems. However, these two tissues appeared to act differently in response to the different level of dehydration they experience. Besides, they can affect each other via the signaling and transportation system.
Cell shape information is transduced through tension-independent mechanisms (2017)

The shape of a cell within tissues can represent the history of chemical and physical signals that it encounters, but can information from cell shape regulate cellular phenotype independently? Using optimal control theory to constrain reaction-diffusion schemes that are dependent on different surface-to-volume relationships, we find that information from cell shape can be resolved from mechanical signals. We used microfabricated 3-D biomimetic chips to validate predictions that shape-sensing occurs in a tension-independent manner through integrin β<sub>3</sub> signaling pathway in human kidney podocytes and smooth muscle cells. Differential proteomics and functional ablation assays indicate that integrin β<sub>3</sub> is critical in transduction of shape signals through ezrin-radixin-moesin (ERM) family. We used experimentally determined diffusion coefficients and experimentally validated simulations to show that shape sensing is an emergent cellular property enabled by multiple molecular characteristics of integrin β<sub>3</sub>. We conclude that 3-D cell shape information, transduced through tension-independent mechanisms, can regulate phenotype.
Effects of L-carnitine on nitrogen retention and blood metabolites of growing steers and performance of finishing steers. (2001)

Two experiments were conducted to evaluate L-carnitine supplementation to cattle fed grain-based diets. In Exp. 1, seven Angus-cross steers (216 kg) were used in a 7 x 4 incomplete Latin square experiment to evaluate the effects of supplemental L-carnitine on N balance and blood metabolites. Steers were fed a corn-based diet (17.5% CP) at 2.5% of BW. Treatments were 0, 0.25, 0.5, 1.0, 1.5, 2.0, and 3.0 g/d of supplemental carnitine. The 18-d periods included 13 d for adaptation and 5 d for collection of feces and urine. Blood was collected before feeding and 3 and 6 h after feeding on d 18 of each period. Dry matter intakes tended to be highest when 1.5 g/d of carnitine was supplied, but N retention was not affected by carnitine and averaged 29.3 g/d. Plasma carnitine concentrations and urinary excretion increased with increasing carnitine supply, indicating that at least some of the carnitine escaped ruminal degradation and was absorbed by the steers. Plasma concentrations of NEFA demonstrated a treatment x time interaction; they decreased linearly in response to carnitine before feeding but increased linearly in response to carnitine at 6 h after feeding. Serum insulin and plasma glucagon, IGF-I, cholesterol, triglyceride, and amino acids were not affected by carnitine. Plasma concentrations of glucose, glycerol, urea, and beta-hydroxybutyrate all were increased by some of the levels of carnitine supplementation, but results for these measurements did not follow easily described patterns and seemed to be related to differences in DMI. In Exp. 2, 95 crossbred steers (357 kg initial BW) were fed finishing diets (14.5% CP) for 129 d. Diets were based on steam-flaked corn and contained 6% alfalfa and 4% tallow. Feed intakes, gains, and feed efficiencies were not affected by supplementation with 2 g/d L-carnitine. However, steers receiving L-carnitine tended to have fatter carcasses, as indicated by tendencies (P < 0.2) for thicker backfat, higher marbling scores, and higher yield grades. In conclusion, carnitine supplementation did not alter lean deposition in growing steers but it did alter plasma NEFA concentrations of growing steers fed a corn-based diet and also seemed to increase fat deposition in finishing cattle.