gebhart/patrepeval huggingface dataset:
A 3.4mW/element Radiation-Hardened Ka-Band CMOS Phased-Array Receiver Utilizing Magnetic-Tuning Phase Shifter for Small Satellite Constellation (2022)

Low-Earth-Orbit (LEO) satellite constellations have been demonstrated as a ground breaking technology for providing low-cost low-latency global internet access. However, each satellite needs more than 200kg launch mass due to bulky wireless components and solar cells, which raises a serious cost issue. One possible solution is further minimizing satellite mass, such as cube satellites, by realizing an ultra-low-power Kaband phased-array transceiver. In this work, 1W power consumption is targeted for a 256-element Ka-band phased-array receiver, i.e. 4mW per element. In the conventional geostationary communication satellites, a parabolic antenna is utilized, and a transceiver module is placed inside a metallic cavity so it can tolerate cosmic radiation. On the other hand, LEO satellites need beam-steering functionality by using a phased-array antenna, and only a thin shield layer can be inserted between antennas and ICs for avoiding redundant mass and insertion loss. Thus, the radiation-hardening and low power consumption are key requirements for such cube satellite phased arrays. For RF building blocks in a phased array, the total ionizing dose (TID) is more critical than the single event effects (SEE). Figure 4.8.1 shows an estimated result for non-radiation-hardened design regarding TID degradation on beam pattern, resulting in 3.8dB main-lobe degradation. In this work, 2.7Mrad TID tolerance is considered adequate for a 3-year lifespan with a 24pm PCB copper shield. Figure 4.8.1 also summarizes the system requirements for a phased-array satellite receiver.
The action of BDNF on GABAA currents changes from potentiating to suppressing during maturation of rat hippocampal CA1 pyramidal neurons (2003)

During the development of the hippocampus, the action of GABA shifts from depolarizing to hyperpolarizing, and brain-derived neurotrophic factor (BDNF) has important roles in GABAergic transmission. We demonstrate that BDNF (20 ng ml(−1)) rapidly and reversibly potentiates postsynaptic GABA(A) receptor-mediated currents (by 80.5 ± 14.3 %, n = 10) in hippocampal CA1 pyramidal neurons isolated from postnatal day (P)6 rats, using nystatin-perforated patch-clamp recordings. This potentiation is caused by an elevation of intracellular Ca(2+) that occurs in response to the activation of Trk B receptor tyrosine kinase and phospholipase C-γ. The modulation of the GABA(A) responses by BDNF in hippocampal CA1 pyramidal neurons isolated from P10 rats was more diverse (from potentiating to inhibitory), and at P14, BDNF induced a long-lasting inhibition. In addition, Ca(2+)/calmodulin-dependent protein kinase 2 plays important roles in the potentiating, but not in the inhibitory effect, of BDNF on the GABA(A) responses. These results suggest that changes in the intracellular signalling pathway could contribute to the developmental shift of the actions of BDNF on inhibitory systems.
Indication for Different Mechanisms of Kidney Uptake of Radiolabeled Peptides (2007)

Inhibition of renal accumulation of the radiopeptides tested could be achieved by either Lys or PGA but not by both at the same time, suggesting 2 different uptake mechanisms. The differences in renal accumulation of radiopeptides may be related to the number of charges of a molecule. GF is the only compound that inhibited renal accumulation of all radiopeptides tested. Additional experiments are needed to further elucidate these findings and to optimize inhibition of renal accumulation of radiopeptides to reduce the kidney dose in PRRT.
Primary cilia signaling mediates intraocular pressure sensation (2014)

Lowe syndrome is a rare X-linked congenital disease that presents with congenital cataracts and glaucoma, as well as renal and cerebral dysfunction. OCRL, an inositol polyphosphate 5-phosphatase, is mutated in Lowe syndrome. We previously showed that OCRL is involved in vesicular trafficking to the primary cilium. Primary cilia are sensory organelles on the surface of eukaryotic cells that mediate mechanotransduction in the kidney, brain, and bone. However, their potential role in the trabecular meshwork (TM) in the eye, which regulates intraocular pressure, is unknown. Here, we show that TM cells, which are defective in glaucoma, have primary cilia that are critical for response to pressure changes. Primary cilia in TM cells shorten in response to fluid flow and elevated hydrostatic pressure, and promote increased transcription of TNF-α, TGF-β, and GLI1 genes. Furthermore, OCRL is found to be required for primary cilia to respond to pressure stimulation. The interaction of OCRL with transient receptor potential vanilloid 4 (TRPV4), a ciliary mechanosensory channel, suggests that OCRL may act through regulation of this channel. A novel disease-causing OCRL allele prevents TRPV4-mediated calcium signaling. In addition, TRPV4 agonist GSK 1016790A treatment reduced intraocular pressure in mice; TRPV4 knockout animals exhibited elevated intraocular pressure and shortened cilia. Thus, mechanotransduction by primary cilia in TM cells is implicated in how the eye senses pressure changes and highlights OCRL and TRPV4 as attractive therapeutic targets for the treatment of glaucoma. Implications of OCRL and TRPV4 in primary cilia function may also shed light on mechanosensation in other organ systems.
On the occurrence of ground observations of ELF/VLF magnetospheric amplification induced by the HAARP facility (2011)

[1] The ionospheric heating facility of the High Frequency Active Auroral Research Program (HAARP) has been used extensively in the last 3 years for injection of ELF/VLF waves into the magnetosphere via modulated heating of the overhead auroral electrojet currents. Of particular interest are waves that are observed to be nonlinearly amplified after interaction with hot plasma electrons in the Earth's radiation belts. Past results have shown HAARP to be an effective platform for controlled studies of wave particle interactions in the Earth's magnetosphere. A summary of the experimental results is provided in the context of dependencies on geomagnetic conditions and transmitter parameters. It is deduced that the primary variable that is associated with successful ground observations of HAARP-induced magnetospheric amplification is availability of magnetospheric wave guiding structures. Such structures are found to be most prevalent under quiet geomagnetic conditions following a disturbance when the plasmapause extends to the latitude of the HAARP facility or higher. Strong electrojet currents and high amplitudes of generated ELF/VLF signals observed on the ground are poor indicators of observation probability on a day to day basis although variation of these variables can be important on minute and second timescales. Frequency-time formats with continuously increasing ELF/VLF frequency show preferential amplification as predicted by nonlinear theory of electron trapping. Amplification of signals is also found to be possible for signals with noncoherent bandwidths of up to 30 Hz.
Clonal Analysis of a Case of Multiple Meningiomas Using Multiple Molecular Genetic Approaches: Pathology Case Report (1999)

Taken together, this case of multiple meningiomas was most likely monoclonal in origin. Loss of chromosome 22 was an early event during the development of multiple meningiomas and was followed by mutations at the NF2 locus. Later events, including loss of the X chromosome, variation of AR gene expression, or microsatellite instability, may also have played a role in the development of multiple meningiomas in this patient.
Structural Conditions for Projection-Cost Preservation via Randomized\n Matrix Multiplication (2017)

Projection-cost preservation is a low-rank approximation guarantee which\nensures that the cost of any rank-$k$ projection can be preserved using a\nsmaller sketch of the original data matrix. We present a general structural\nresult outlining four sufficient conditions to achieve projection-cost\npreservation. These conditions can be satisfied using tools from the Randomized\nLinear Algebra literature.\n
7Li MAS NMR Study of the Lithium Iron Phosphate System for Li-Ion Batteries (2013)

Abstract not Available.
Evaluation of a novel extended automated particle-based multi-analyte assay for the detection of autoantibodies in the diagnosis of primary biliary cholangitis (2020)

PBC antibody profiling, made possible by the new Aptiva-PMAT technology, allows recognition of a higher number of AMA-negative PBC patients than conventional immunoassays and may represent a useful tool to evaluate the prognostic significance of autoantibody association in PBC patients.
eNGene: An ARM Based Embedded Real-time Software GNSS Receiver (2015)

GNSS receivers take advantage from the software defined radio approach because they can use the intrinsic flexibility to evolve toward new satellite positioning systems and applications. For this type of implementation the use of embedded platforms is particularly interesting, due to the associated portability and low cost. This paper describes the porting of a software GNSS receiver designed for a PC on an ARM-based board, with emphasis on the adopted solutions and the effects on the achieved performance with respect to the implementation for PC.
Safety and tolerability of edivoxetine as adjunctive treatment to selective serotonin reuptake inhibitor antidepressants for patients with major depressive disorder (2015)

The tolerability and safety profile of edivoxetine as adjunctive treatment to SSRI antidepressants was consistent with its norepinephrine reuptake inhibitor mechanism of action, and was comparable with edivoxetine monotherapy treatment in patients with major depressive disorder.
Toll-Like Receptor 9 Agonists for Cancer Therapy (2014)

The immune system has acquired increasing importance as a key player in cancer maintenance and growth. Thus, modulating anti-tumor immune mediators has become an attractive strategy for cancer treatment. Toll-like receptors (TLRs) have gradually emerged as potential targets of newer immunotherapies. TLR-9 is preferentially expressed on endosome membranes of B-cells and plasmacytoid dendritic cells (pDC) and is known for its ability to stimulate specific immune reactions through the activation of inflammation-like innate responses. Several synthetic CpG oligonucleotides (ODNs) have been developed as TLR-9 agonists with the aim of enhancing cancer immune surveillance. In many preclinical models, CpG ODNs were found to suppress tumor growth and proliferation both in monotherapy and in addition to chemotherapies or target therapies. TLR-9 agonists have been also tested in several clinical trials in patients with solid tumors. These agents showed good tolerability and usually met activity endpoints in early phase trials. However, they have not yet been demonstrated to significantly impact survival, neither as single agent treatments, nor in combination with chemotherapies or cancer vaccines. Further investigations in larger prospective studies are required.
1H‐NMR studies of high‐potential iron‐sulfur protein from the purple phototrophic bacterium, Rhodospirillum tenue (1989)

The high-potential iron-sulfur protein (HiPIP) from Rhodospirillum tenue (strain 3761) shows only a weak (20-25%) sequence similarity to HiPIPs from Chromatium vinosum, Ectothiorhodospira halophila and Ectothiorhodospira vacuolata, including the strict conservation of only two of the twelve residues assumed to be in the 4Fe-4S cluster packing region [Tedro, S. M., Meyer, T. E. and Kamen, M. D. (1979) J. Biol. Chem. 254, 1495-1500]. In spite of these differences, the general range and distribution of hyperfine-shifted 1H-NMR peaks of oxidized and reduced R. tenue HiPIP resemble those of E. halophila HiPIP I [Krishnamoorthi, R., Markley, J. L., Cusanovich, M. A., Pryzycieki, C. T. and Meyer, T. E. (1986) Biochemistry 25, 60-67]. Temperature- and pH-dependence and longitudinal relaxation behavior were determined for hyperfine-shifted peaks of the oxidized protein. Tentative assignments of peaks to ligands and aromatic residues suggest the presence of common apoprotein-active-site interactions in these proteins. Differences occur in the pattern of paramagnetically shifted peaks attributed to hydrogens bonded to the 4Fe-4S cluster. Hyperfine-shifted peaks of R. tenue HiPIP are not perturbed by pH changes in the range 5-9. In contrast, those of the C. vinosum protein exhibit a pH-dependence of chemical shifts that has been attributed to the titration of His42 [Nettesheim, D. G., Meyer, T. E., Feinberg, B. A. and Otvos, J. D. (1983) J. Biol. Chem. 258, 8235-8239]. Since R. tenue HiPIP contains no histidine, the present observation confirms the above hypothesis.
Star-Shaped Discotic Oligomesogens Based on Radial Pentakisphenylethynylbenzene Moieties (2005)

New monodisperse star-shaped discotic oligomesogens are presented which consist of three flat radial pentaalkyne building blocks connected with a central benzene linking unit via flexible alkyl spacers. Different alkyl substituents were attached to the periphery of the pentayne units in order to modify the molecular dimensions. The thermal properties of the star oligomers in their pure state and of donor-acceptor complexes with 2,4,7-triniti-ofluoren-9-one (TNF) were investigated by polarizing microscopy, differential scanning calorimetry, and X-ray scattering. The pentayne oligomers as well as the binary mixtures with TNF exhibit a nematic-columnar (N-Col) mesophase. On the contrary, the corresponding hydroxy-substituted pentayne monomers display a nematic-discotic (N-D) liquid crystalline phase as pure compounds, and CT interactions with TNF lead to the induction of hexagonal columnar (Col(h)) mesophases. The unexpected phase behavior of the oligomers and of the CT complexes derived there from is mainly the result of the molecular architecture arising from covalent linkage of the flat anisometric moieties.
Deep convolutional neural networks for LVCSR (2013)

Convolutional Neural Networks (CNNs) are an alternative type of neural network that can be used to reduce spectral variations and model spectral correlations which exist in signals. Since speech signals exhibit both of these properties, CNNs are a more effective model for speech compared to Deep Neural Networks (DNNs). In this paper, we explore applying CNNs to large vocabulary speech tasks. First, we determine the appropriate architecture to make CNNs effective compared to DNNs for LVCSR tasks. Specifically, we focus on how many convolutional layers are needed, what is the optimal number of hidden units, what is the best pooling strategy, and the best input feature type for CNNs. We then explore the behavior of neural network features extracted from CNNs on a variety of LVCSR tasks, comparing CNNs to DNNs and GMMs. We find that CNNs offer between a 13-30% relative improvement over GMMs, and a 4-12% relative improvement over DNNs, on a 400-hr Broadcast News and 300-hr Switchboard task.
Interest flooding attack and countermeasures in Named Data Networking (2013)

Distributed Denial of Service (DDoS) attacks are an ongoing problem in today’s Internet, where packets from a large number of compromised hosts thwart the paths to the victim site and/or overload the victim machines. In a newly proposed future Internet architecture, Named Data Networking (NDN), end users request desired data by sending Interest packets, and the network delivers Data packets upon request only, effectively eliminating many existing DDoS attacks. However, an NDN network can be subject to a new type of DDoS attack, namely Interest packet flooding. In this paper we investigate effective solutions to mitigate Interest flooding. We show that NDN’s inherent properties of storing per packet state on each router and maintaining flow balance (i.e., one Interest packet retrieves at most one Data packet) provides the basis for effective DDoS mitigation algorithms. Our evaluation through simulations shows that the solution can quickly and effectively respond and mitigate Interest flooding.
A 2.7 in. 1.3 MPixel driver-integrated poly-Si TFT-LCD for multimedia projectors (2002)

The rapid progress of multimedia demands liquid crystal display (LCD) projectors that can display computer data, such as video-graphic arrays (VGA), super-video-graphic arrays (SVGA), extended-graphic arrays (XGA) and super-extended-graphic arrays (SXGA). One of the major challenges for poly-Si TFT drivers in such multi-scan LCDs is displaying as black in the peripheral region around the picture during a blanking period. Using conventional shift register driver circuits, the scanning speed in the up-and-down no-picture region is too high for pixel TFTs to write signals for black. Although decoder driver circuits for multi-scan operation have been introduced into an HDTV poly-Si TFT-LCD, they require many address signals and logic gates. These increase circuit area and thereby decrease the manufacturing yields. Poly-Si TFT drivers use a combination of bi-directional shift registers and decoder circuits to solve the above problems for a 2.7 in, 1.3 Mpixel TFT LCD light valve.
Comprehensive and quantitative analyses of nitrogen and aroma metabolism during wine fermentation (2014)

Comprehensive and quantitative analyses of nitrogen and aroma metabolism during wine fermentation. Macrowine 2014
Evolution of phosphorus-vacancy clusters in epitaxial germanium (2019)

The E centers (dopant-vacancy pairs) play a significant role in dopant deactivation in semiconductors. In order to gain insight into dopant-defect interactions during epitaxial growth of in situ phosphorus doped Ge, positron annihilation spectroscopy, which is sensitive to open-volume defects, was performed on Ge layers grown by chemical vapor deposition with different concentrations of phosphorus (∼1×1018–1×1020cm−3). Experimental results supported by first-principles calculations based on the two component density-functional theory gave evidence for the existence of mono-vacancies decorated by several phosphorus atoms as the dominant defect type in the epitaxial Ge. The concentration of vacancies increases with the amount of P-doping. The number of P atoms around the vacancy also increases, depending on the P concentration. The evolution of Pn–V clusters in Ge contributes significantly to the dopant deactivation.
Multiple Facial Papules and Macrocephaly—Quiz Case (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
High temperature materials for aerospace applications: Ni-based superalloys and γ-TiAl alloys (2018)

Two outstanding aerospace-oriented high-temperature materials, the single-crystal nickel-based superalloys for high-pressure turbine blades and the γ -TiAl-based alloys for low pressure turbine blades, are being presented here. In both cases, the optimisation of their mechanical properties is based on a high knowledge of metallurgy, mixing together different aspects such as processes, alloy design, deformation mechanisms, impact of oxidative environment or interaction between protective layers and protected alloy. Historical evolutions are recalled and put into perspective with more recent research activities.
Development of RIKEN Plant Metabolome MetaDatabase (2021)

The advancement of metabolomics in terms of techniques for measuring small molecules has enabled the rapid detection and quantification of numerous cellular metabolites. Metabolomic data provide new opportunities to gain a deeper understanding of plant metabolism that can improve the health of both plants and humans that consume them. Although major public repositories for general metabolomic data have been established, the community still has shortcomings related to data sharing, especially in terms of data reanalysis, reusability and reproducibility. To address these issues, we developed the RIKEN Plant Metabolome MetaDatabase (RIKEN PMM, http://metabobank.riken.jp/pmm/db/plantMetabolomics), which stores mass spectrometry-based (e.g. gas chromatography-MS-based) metabolite profiling data of plants together with their detailed, structured experimental metadata, including sampling and experimental procedures. Our metadata are described as Linked Open Data based on the Resource Description Framework using standardized and controlled vocabularies, such as the Metabolomics Standards Initiative Ontology, which are to be integrated with various life and biomedical science data using the World Wide Web. RIKEN PMM implements intuitive and interactive operations for plant metabolome data, including raw data (netCDF format), mass spectra (NIST MSP format) and metabolite annotations. The feature is suitable not only for biologists who are interested in metabolomic phenotypes, but also for researchers who would like to investigate life science in general through plant metabolomic approaches.