gebhart/patrepeval huggingface dataset:
Aging of lens fibers. Mapping membrane proteins with monoclonal antibodies. (1986)

Lens fiber proteins with apparent molecular weights 57,000, 70,000, 82,000, and 100,000 were components in urea insoluble, membrane-rich fractions. Monoclonal antibodies against these proteins labeled membranes by immunofluorescence microscopy of sheep lens cryosections and are thus referred to as membrane proteins MP57, MP70, MP82, and MP100. MP70 has previously been localized in fiber junctional membranes (Kistler et al 1985, J Cell Biol 101:28-35). Using radioimmunoassays, the authors found a different membrane protein composition for the cortical and nuclear sheep lens regions. In addition, the membrane protein composition altered with the overall lens age. All the above membrane antigens were eventually cleaved by proteolysis in older fibers, and their degradation patterns could be grouped into distinct classes. The results are of basic importance for cataract research.
Atomic layer deposition of hafnium oxide from tert-butoxytris(ethylmethylamido)hafnium and ozone: rapid growth, high density and thermal stability (2008)

HfO2 thin films were grown by atomic layer deposition (ALD) using a novel heteroleptic precursor, tert-butoxytris(ethylmethylamido)hafnium [HfOtBu(NEtMe)3; BTEMAH] and ozone. The structure of BTEMAH is similar to that of tetrakis(ethylmethylamido)hafnium [Hf(NEtMe)4; TEMAH] except that one of its four amido ligands is replaced with a tert-butoxy ligand. This heteroleptic structure largely improves the ALD growth rate (0.16 nm cycle−1) and Hf density (Hf mass per unit volume of HfO2 film, 7.6 g cm−3) of the HfO2 films. The self-regulated ALD growth behavior was confirmed at a growth temperature of 300 °C. Higher Hf density induces anti-crystallization properties in the as-grown film. Consequently, the amorphous phase of a HfO2 film is retained up to ∼15 nm during deposition at 300 °C. The more amorphous-like nature and the higher Hf density of the HfO2 film also retard crystallization during post-deposition annealing (PDA), which strongly enhances the thermal stability of the electrical performance. The capacitance equivalent thickness of the films with thicknesses ranging from 4 to 13 nm is relatively constant up to a PDA temperature of 1000 °C.
The First Total Synthesis of 6-Sulfo-de-N-acetylsialyl Lewisx Ganglioside: A Superior Ligand for Human L-Selectin (1999)

Originally discovered as a minor by-product of 6-sulfo-N-acetylsialyl Lewis(x) , the de-N-acetylated form 1 is a superior L-selectin ligand to the N-acetyl form. To substantiate the extraordinary reactivity of 1, it was synthesized for the first time and its binding to L-selectin investigated. Compound 1 and related structures may be high-affinity endogenous ligands for L-selectin that are involved in the interaction of leukocytes with the vascular endothelium.
The First Canadian Fibre-Optic CATV Trunking System (1979)

The economic and technical criteria which guided the design and development of the first operational fibre-optic cable TV trunking system in North America are presented. A description is given of system hardware with emphasis on unique technical advancements. System parameters, test results and digital data transmission capabilities are discussed.
Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease (2021)

Congenital heart defects constitute the most common human birth defect, however understanding of how these disorders originate is limited by our ability to model the human heart accurately in vitro. Here we report a method to generate developmentally relevant human heart organoids by self-assembly using human pluripotent stem cells. Our procedure is fully defined, efficient, reproducible, and compatible with high-content approaches. Organoids are generated through a three-step Wnt signaling modulation strategy using chemical inhibitors and growth factors. Heart organoids are comparable to age-matched human fetal cardiac tissues at the transcriptomic, structural, and cellular level. They develop sophisticated internal chambers with well-organized multi-lineage cardiac cell types, recapitulate heart field formation and atrioventricular specification, develop a complex vasculature, and exhibit robust functional activity. We also show that our organoid platform can recreate complex metabolic disorders associated with congenital heart defects, as demonstrated by an in vitro model of pregestational diabetes-induced congenital heart defects.
Physicochemical assessment of urban wastewater of Cotonou (Benin) (2021)

The present study aims to fill the data gap analysis in urban wastewaters characteristics in Benin and its statistical analysis. Physicochemical parameters such as pH, electrical conductivity (EC), Chemical Oxygen Demand (COD), Biochemical Oxygen Demand (BOD<sub>5</sub>), Total Kjeldahl Nitrogen (TKN), Total Phosphorus (TP) and UV Absorbance at 254 nm, were determined on domestic (greywater and blackwater) and industrial (hospital, pharmaceutical and commercial laundry) wastewater in Cotonou city. Analysis of variance showed a strong significant difference in the physico-chemistry of the various effluents. The pharmaceutical wastewater has the highest concentration of organic pollution (COD = 5,912 ± 1,026 mg/L, Abs.UV254 = 2.667 ± 0.327 cm<sup>-1</sup>). The organic load of blackwater is mainly in particulate and biodegradable form. Besides, the correlation study showed the limits of pH and EC as an indicator of organic load. Furthermore, the choice of COD or BOD<sub>5</sub> as the main design parameter would be limited to blackwater treatment. Abs.UV254 was found to be the parameter having a strong relationship with other parameters of all effluents except blackwater. It then takes priority over COD for the treatment of greywater and industrial wastewater. For future wastewater treatment plant design, we recommend to consider Abs.UV254 as an important parameter.
An efficient algorithm for 3D rectangular box packing (2009)

Akyokuş, Selim (Dogus Author) -- Conference full title: 9th International Conference, ETAI 2009, Ohrid, September 26-29, Republic of Macedonia, 2009.
Production performance and blood biochemical changes in broiler chickens fed amla during induced-stress conditions. (2009)

An experiment was conducted in broiler chickens to evaluate the efficacy of Emblica officinalis (amla) fruits rich in vitamin C in alleviating stress induced by ACTH injection @ 3 IU / kg body weight for 5 d from 22 d of age. The birds were fed standard broiler diet supplemented with 5, 10 or 20 g amla dry powder or 250 mg synthetic vitamin C / kg diet. Body weight and feed efficiency were measured weekly. The plasma glucose, serum total cholesterol, high-density lipoprotein and triglycerides were measured at 21, 28 and 42 d of age. The results suggested that while the mean body weight was not influenced by amla supplementation, the feed efficiency was significantly improved by 10 g / kg amla feeding, compared to other groups. Serum triglycerides level decreased in amla-fed groups compared to control at third and fourth weeks of age. Other blood biochemical parameters like plasma glucose, serum total cholesterol and highdensity lipoprotein did not vary between treatments. It can be concluded that the broiler diet can be supplemented with amla at 10 g / kg as an anti-stress agent during stress periods of broiler production.
Observation of the Density Threshold Behavior for the Onset of Stimulated Raman Scattering in High-Temperature Hohlraum Plasmas (2009)

We show that the measured stimulated Raman scattering (SRS) in a large-scale high-temperature plasma scales strongly with the plasma density, increasing by an order of magnitude when the electron density is increased by 20%. This is consistent with linear theory, including pump depletion, in a uniform plasma and, as the density is typically constrained by other processes, this effect will set a limit on drive laser beam intensity for forthcoming ignition experiments at the National Ignition Facility. Control of SRS at laser intensities consistent with 285 eV ignition hohlraums is achieved by using polarization smoothing which increases the intensity threshold for the onset of SRS by 1.6 +/- 0.2. These results were quantitatively predicted by full beam three-dimensional numerical laser-plasma interaction simulations.
The effects of nanopillar surface texturing on the photoluminescence of polymer films (2010)

We report on the enhancement of photoluminescence (PL) from polymer thin films by nanotexturing their surfaces using nanoporous anodic alumina oxide templates. Chromophore-embedded polystyrene films with nanostructured surfaces are prepared by imprinting 200 nm diameter nanopillars with various heights, and their PL output and angular emission are observed. The PL output increases and the angular distributions broaden as the height of the nanopillars increases. For 5 μm tall nanopillars, the PL output is enhanced by a factor of 2.5 relative to the smooth surface. An effective refractive index model provides a qualitative description of the angular emission and PL output of nanotextured surface but underestimates the degree of PL enhancement. Comparison of the nanopillared films with surfaces randomly roughened using sandpaper shows that the details of the texturing have a significant impact on the PL output characteristics. These results show that imprinted nanopillars provide a simple and controlled way to increase the PL output of luminescent polymer films.
A new hybrid nanocomposite prepared by emulsion copolymerization of ABS in the presence of clay (2001)

The preparation and characterizations of new hybrid organic–inorganic nanocomposites consisting of acrylonitrile–butadiene–styrene terpolymer and a Na+-exchanged montmorillonite (MMT) are described by direct intercalation through one-step emulsion polymerization. Those products were purified by successive hot acetone and toluene extraction, respectively, for more than 2 days. The IR spectra for the purified samples revealed the characteristic absorbances as a result of those of styrene, butadiene, acrylonitrile, and MMT. X-ray diffraction spectra of the composites showed the enlarged 001 d-spacing as much as 1.75 nm, but no signals were found for the partial insertion of copolymer chains. Moreover, it was evident that this direct intercalation was not accompanied by delamination of the clay interlayer. The thermogravimetric analytic measurement for the purified product confirmed that the onset temperature of decomposition was transferred to the higher temperature region as much as 40–50 °C. Morphological observations by transmission electron microscopy, scanning electron microscopy, and optical micrography demonstrated homogeneous dispersion of MMT particles in the copolymer matrix. The possible physical picture of this direct intercalation was discussed in terms of swelling characteristics of compacted bentonite and the monomer containing micelle sizes. © 2001 John Wiley & Sons, Inc. J Polym Sci B: Polym Phys 39: 719–727, 2001
Nuklearmedizinische Ultraschall-Fusionsbildgebung – Klinische Möglichkeiten und derzeitige Limitationen (2023)

Zusammenfassung Die nuklearmedizinische Ultraschall-Fusionsbildgebung lässt sich unter anderem für die Diagnostik der Schilddrüse und Nebenschilddrüsen klinisch sinnvoll einsetzen und erlaubt die zweifelsfreie räumliche Korrelation metabolischer und morphologischer Informationen. Allerdings beschränkt sich die praktische Anwendung aufgrund derzeit noch limitierender Aspekte auf ausgewählte Fälle und wissenschaftliche Untersuchungen. Die Entwicklung eines integrierten hybriden Detektors zur simultanen nuklearmedizinisch-sonografischen Bildgebung wäre eine Möglichkeit, die bestehenden Limitationen zu überwinden.
Depth-based action recognition using multiscale sub-actions depth motion maps and local auto-correlation of space-time gradients (2016)

This paper presents a method for human action recognition from depth sequence. First, we subdivided the normalized motion energy vector into a set of segments, whose corresponding frame indices are used to partition a video. Then each sub-action is represented by three Depth Motion Maps (DMMs) to capture motion cues in three orthogonal projection views. Multi-scale Histogram of Oriented Gradients (HOG) descriptors are then computed from the DMMs for capturing the appearance cues. In order to cope with the temporal information loss in the DMMs generation, one complementary feature, a 3D motion feature descriptor, is extracted from the depth video utilizing local space-time auto-correlation of gradients (STACOG). Discriminative Multiple Canonical Correlation Analysis (DM-CCA) is then adopted to analyze DMMs-based feature and STACOG, and the two sets of features are fused into a more complete and discriminative representation of the information embedded in the dataset. l <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> -regularized Collaborative Representation Classification (l <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> -CRC) is applied to classify the proposed descriptors. Evaluations on MSR Action3D and MSRGesture3D Datasets demonstrate the effectiveness of the proposed method.
On the Computational Power of Winner-Take-All (2000)

This article initiates a rigorous theoretical analysis of the computational power of circuits that employ modules for computing winner-take-all. Computational models that involve competitive stages have so far been neglected in computational complexity theory, although they are widely used in computational brain models, artificial neural networks, and analog VLSI. Our theoretical analysis shows that winner-take-all is a surprisingly powerful computational module in comparison with threshold gates (also referred to as McCulloch-Pitts neurons) and sigmoidal gates. We prove an optimal quadratic lower bound for computing winner-take-all in any feedforward circuit consisting of threshold gates. In addition we show that arbitrary continuous functions can be approximated by circuits employing a single soft winner-take-all gate as their only nonlinear operation. Our theoretical analysis also provides answers to two basic questions raised by neurophysiologists in view of the well-known asymmetry between excitatory and inhibitory connections in cortical circuits: how much computational power of neural networks is lost if only positive weights are employed in weighted sums and how much adaptive capability is lost if only the positive weights are subject to plasticity.
Research for pedestrian navigation positioning method based on MEMS sensors (2015)

With the development of MEMS sensors, pedestrian navigation has been a popular research. The paper realizes step detection and estimation for step length by only vertical accelerometer. It determines initial heading using accelerometers and magnetometers and calculates latter heading using gyroscopes by strap-down inertial navigation algorithm. Afterwards, it achieves the positioning goal for pedestrian using dead reckoning method. Definitively, the effectiveness of this approach is demonstrated through two different field trials and the results indicate that the positioning method for pedestrian proposed is efficient and has a small positioning error.
Inhibition of SLPI ameliorates disease activity in experimental autoimmune encephalomyelitis (2012)

In EAE, SLPI exerts potent pro-inflammatory actions by modulation of T-cell activity and its neutralization may be beneficial for the disease.
Review of the 2016 European dyslipidaemia guidelines (2016)

In 2016 the European Society of Cardiology (ESC) published guidelines on the prevention of cardiovascular disease (CVD) in clinical practice, with sections addressing global strategies to minimise the burden of CVD at population and individual levels. A few months later in August, the 2016 ESC / European Atherosclerosis Society (EAS) published guidelines for the management of dyslipidaemias, focusing on their evaluation and treatment.
A novel method for estimating an individual’s deviation from their habitual motion path when running (2019)

The current literature on footwear cushioning and pronation has suggested that there may not be a relationship between chronic injury risk and these parameters based on mixed findings and lack of evidence of an association with prospective injury rates. Since footwear has been designed and developed based on cushioning and pronation, we suggest that we have possibly been on a misguided path in footwear design for the last few decades. Current thought thus implies that a new method of footwear prescription is necessary if we are to guide runners toward appropriate footwear that accommodates their individual biomechanical patterns during running. Based on a series of studies investigating the response of the leg to movement and loading patterns, we developed a novel paradigm based on Nigg’s ‘preferred movement path’. The assumptions of the ‘preferred motion path’ were modified in the new method and refined as the ‘habitual motion path’. We focused on knee motion in addition to foot and ankle motion since the greatest number of injuries to runners is at the knee. We utilized a kinematic method for developing a calculation to determine the deviation of a runner’s joint motion path during running from their habitual motion path. We used this deviation as an index for the individual prescription of an appropriate running shoe. While this new method matches a runner based only on their biomechanics, there are other factors that need to be considered. For example, in footwear selection, the individual’s training and injury history in addition to the experience that the runner is seeking from their run must also be considered.
FingerReader2.0 (2018)

People with Visual Impairments (PVI) experience greater difficulties with daily tasks, such as supermarket shopping. Identifying and purchasing an item proves challenging for PVI. Using a user-centered design process, we understand the difficulties PVI encounter in their daily routines. Consequently, the previous FingerReader model was elevated to a new level. In contrast, FingerReader2.0 incorporates a highly integrated hardware design, as it is standalone, wearable, and not tethered to a computer. Software-wise, the prototype utilizes a deep learning system, relying on a hybrid, an on-board and a cloud-based model. The advanced design significantly extends the range of mobile assistive technology, particularly for shopping purposes. This paper presents the findings from interviews, several iterative studies, and a field study in supermarkets to demonstrate the FingerReader2.0's enhanced capabilities for those with varied levels of visual impairment.
Relation between serum uric acid and blood pressure in adolescents (1993)

In adults, serum uric acid is positively associated with blood pressure levels. It is also a predictor of the development of hypertension in normotensive adults. The purpose of this study was to examine the relation of serum uric acid to systolic and diastolic blood pressure in adolescents. The data, from Cycle III of the National Health Examination Survey, consisted of a national probability sample of 6768 youths, 12-17 years old, in the United States. With age, height, weight, and sexual maturity controlled, serum uric acid significantly predicted blood pressure in adolescents. This relationship of uric acid and blood pressure was evident in male, but not female, adolescents. In association with findings from adult studies, these results indicate that uric acid levels may be useful indicators of adolescents at risk for hypertension.
Drastic sensitivity enhancement of temperature sensing based on modal interference in plastic optical fibers (2015)

It has been reported that temperature sensors based on modal interference in perfluorinated graded-index (GI) plastic optical fibers (POFs) show the world’s highest temperature sensitivity of +49.8 nm/&deg;C/m at 1300 nm at room temperature, which is over 1800 times the value in silica multimode fibers (MMFs). In this work, we newly find that the temperature sensitivity (absolute value) is significantly enhanced with increasing temperature toward ~70&deg;C, which is close to the glass-transition temperature of the core polymer. When the core diameter is 62.5 &mu;m, the sensitivity at 72 &deg;C at 1300 nm is +202 nm/&deg;C/m, which is approximately 26 times the value obtained at room temperature and even over 7000 times the highest value previously reported using a silica MMF. As the glass-transition temperature of polymers can be generally set to an arbitrary value, this characteristic could be used to develop POF-based temperature sensors with ultra-high sensitivity not only at ~70&deg;C but at arbitrary temperature in future.
Host–guest chemistry that directly targets lysine methylation: synthetic host molecules as alternatives to bio-reagents (2016)

Post-translational methylation is a chemically simple modification, but regulates the function of hundreds of proteins in profound ways. This Feature Article will report on the basic aspects of protein methylation, and will offer a personal perspective on our recent efforts at making supramolecular hosts that can bind and discriminate among post-translationally methylated partners. The article highlights several general lessons drawn from these efforts and related work by other groups. It also describes some ways in which supramolecular approaches are inherently well suited to provide tools that drive new research in the life sciences.
Protective effects of cynaroside on oxidative stress in retinal pigment epithelial cells (2019)

Cynaroside is a flavonoid compound proved to possess antioxidant activity, but its protective effect on age-related macular degeneration still remains unclear. In this study, the protective effects of cynaroside on oxidative stress and apoptosis in retinal pigment epithelial (RPE) cells induced by hydrogen peroxide (H<sub>2</sub> O<sub>2</sub> ) were investigated. Results showed that cynaroside effectively attenuated the decrease of cell activity induced by H<sub>2</sub> O<sub>2</sub> . The total reactive oxygen species can be remitted by decreasing malondialdehyde level, as well as increasing glutathione level, and superoxide dismutase and catalase activities. In addition, Western blot analysis indicated that cynaroside protected ARPE-19 cells from apoptosis through downregulation of caspase-3 protein activation which was controlled by the upstream proteins Bcl-2 and Bax. It was finally proved that cynaroside could enhance the antioxidant and antiapoptotic ability in ARPE-19 cells by promoting the expression of p-Akt.
Differential Diagnosis of Endolymphatic Hydrops Between “Probable” and “Definite” Ménière’s Disease via Magnetic Resonance Imaging (2021)

MRI revealed a higher grade of endolymphatic hydrops in patients with definite Ménière's disease than in patients with probable Ménière's disease. As a result, it may be clinically useful and an effective tool in the differentiation between definite and probable Ménière's disease.
Crystallization and preliminary crystallographic analysis of an Ig-domain-encompassing fragment of the giant adhesion protein SiiE fromSalmonella enterica (2011)

Salmonella infections can be life-threatening. SiiE is a giant adhesion molecule of 5559 amino acids that is encoded in Salmonella pathogenicity island 4 (SPI4) and that promotes the initial contact between the pathogen and polarized epithelial cells in the intestine of the host. Starting from an engineered deletion version of SiiE (mini-SiiE; 97 kDa), limited proteolysis was used to reproducibly generate a 30 kDa fragment that readily crystallized. Mass spectrometry hints that this fragment spans the predicted Ig domains 50-52 of SiiE. Crystals of both native and selenomethionine-labelled protein could be obtained in space group C2 and diffraction data were recorded to a resolution of 1.85 Å.