gebhart/patrepeval huggingface dataset:
N−H Activation of Amines and Ammonia by Ru via Metal−Ligand Cooperation (2010)

A nonoxidative addition pathway for the activation of NH bonds of ammonia and amines by a Ru(II) complex is reported. The pincer complex 1 cleaves N-H bonds via metal-ligand cooperation involving aromatization of the pincer ligand without a change in the formal oxidation state of the metal. Electron-rich N-H bond substrates lead to reversible activation, while electron-poor substrates result in stable activation products. Isotopic labeling studies using ND(3) as well as density functional theory calculations were used to shed light on the N-H activation mechanism.
Assessment of Urinary F 2 -Isoprostanes in Experimental and Clinical Studies: Mass Spectrometry Versus ELISA (2012)

To the Editor:Ojeda and colleagues 1 reported that oxidative stress renal markers contribute to sex differences in blood pressure in adult growth-restricted offspring rats.The antibody used in the ELISA kit used by Ojeda et al 1 isspecificfor15(S)-8-iso-PGF 2␣ , 2 (http://www.oxfordbiomed.com/sites/default/files/spec_sheet/EA85.120426.pdf)one of 64 possible F 2 -isoprostanes.At first glance, ELISA and gas chromatography-mass spectrometry (GC-MS) seem to correlate (Figure ,A); however, the Bland-Altman method reveals enormous differences and systematic errors in the ELISA method (Figure ,B).Lack of analytically satisfactory agreement applies to another commercially available 15(S)-8-iso-PGF 2␣ ELISA kit (http://www.caymanchem.com/pdfs/516351.pdf).15(S)-8-iso-PGF 2␣ is excreted in the urine in free and conjugated forms 3 (Figure C).The lack of appreciable biological variation in urinary excretion in humans 2 and rats (58Ϯ16 pg/mg creatinine; 1 female, 4 male) and the manifold higher reported 15(S)-8-iso-PGF 2␣ levels 1 reveal serious analytic shortcomings with the use of 15(S)-8-iso-PGF 2␣ ELISA kits.This may compromise the scientific outcome.Inclusion of clean-up procedures is likely to improve the analytic performance of ELISA kits. 4 Yet, reliable assessment of 15(S)-8-iso-PGF 2␣ in experimental and clinical study samples is best accomplished by tandem mass spectrometry-based methods. 2,
An analysis of the retrofitting potential of a subcritical ORC into a partial evaporating ORC under off-design operation (2018)

Many applications where ORCs are installed have time varying waste heat streams. To account for this, flexible and robust off-design models are necessary. In addition, alternative operating conditions and cycle architectures show potential for increased performance. This work investigates how operation as a partial evaporating cycle (PEORC) affects the performance of the ORC. More specifically, the question is raised if current subcritical ORC (SCORC) installations provide potential to be retrofitted into PEORC operation by analysing their off-design operation. The initial results show that under these conditions the PEORC shows a potential net power output increase between 2% to 12% relative to the base SCORC depending on the off-design conditions. The optimal expander inlet vapour fraction that maximises the net power output ranges between 0.5 and 1. With roughly the same maximum pressures, the same working fluid, and an adapted measuring and control strategy, significant net power improvements could thus be achieved. It is important to note that for PEORC operation the performance of the pump becomes determinative. Installing a pump with a better efficiency would further benefit operation as PEORC. Based on these results, there are clearly opportunities in retrofitting existing SCORC systems.
A Randomized Prospective Study of Topical Antimicrobial Agents on Skin Grafts after Thermal Injury (1990)

Livingston, David H. M.D.; Cryer, H. Gill M.D., Ph.D.; Miller, Frank B. M.D.; Malangoni, Mark A. M.D.; Polk, Hiram C. Jr. M.D.; Weiner, Leonard J. M.D.; Herndon, David N. M.D. Author Information
Inhibition of Ca++sparks by oxyhemoglobin in rabbit cerebral arteries (2004)

These results support the hypothesis that HbO2 may contract cerebral artery segments in part by inhibition of Ca(++) sparks, leading to decreased large-conductance Ca(++)-activated K+ channel activity, membrane potential depolarization, and enhanced Ca(++) entry through VDCCs.
Development of a Probe Containing Novel Fluorescent Tricyclic-Nucleoside Analogs for Detecting Single Nucleotide Polymorphisms (2015)

Here we report the synthesis of nucleoside analogs containing several aryl groups at the 6-position of the fluorescent tricyclic base, 8-amino-3-(2,3-dihydroxypropyl)imidazo[4′,5′:5,6]pyrido[2,3-d]pyrimidine (1), to expand the fluorescence color range of single nucleotide polymorphism (SNP)-detecting probes.The identity of the RNA target bases could be determined using probes containing an analog with a phenyl group at the 6-position of 1.
Preparation and evaluation of a sustained‐release buckwheat noodle (2015)

These findings indicate that the controlled use of hydrophilic colloids and starches in manufacturing noodles could modulate the glucose sustained-release. © 2015 Society of Chemical Industry.
Data from Expression of Siva-1 Protein or Its Putative Amphipathic Helical Region Enhances Cisplatin-Induced Apoptosis in Breast Cancer Cells: Effect of Elevated Levels of BCL-2 (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;i&gt;cis&lt;/i&gt;-Diaminedichloroplatinum (II) (cisplatin) is routinely used to treat various types of cancers; however, a significant number develop resistance. One of the underlying factors that contribute to cisplatin resistance is the elevated level of BCL-2 and/or BCL-XL, which promotes cell survival. A potential method of overcoming such resistance is to use a potentiator that is capable of neutralizing the antiapoptotic effects of BCL-2/BCL-XL, such as Siva-1. We previously cloned the proapoptotic protein Siva-1 and showed a possible role for it in both extrinsic and intrinsic apoptosis. Using an adenovirus-based expression system, we now show that Siva-1 can synergize with cisplatin in inducing apoptosis in MCF7 and MDA-MB-231 breast cancer cells. In an anchorage-independent clonogenicity assay, MCF7/caspase-3 cells stably expressing Siva-1, but not the control cells, showed a dramatic decrease in the number of colonies formed on one-time cisplatin treatment. Further, we show that the unique putative amphipathic helical region (SAH) in Siva-1 (amino acid residues 36-55) is necessary and sufficient for the observed enhancement in cisplatin-induced apoptosis by Siva-1. Although cisplatin treatment results in significant elevation in the expression of Fas ligand and intracellular p21 levels, expression of Siva-1 has no additional benefit. Instead, the enhancement in apoptosis seems to be due to activation of intrinsic pathway that involves caspase-9 activation. Moreover, Siva-1 augments cisplatin-mediated cell death in MCF7 cells stably expressing BCL-2. We therefore propose that Siva-1 or its SAH region can be used as a potentiator of cisplatin-based chemotherapy.&lt;/p&gt;&lt;/div&gt;
Estimator of static and dynamic torque in switched reluctance motors for alternative energy systems (2006)

A novel torque estimator for accurately computing static and dynamic torque in switched reluctance motors (SRMs) is developed in this paper. It is derived from the analytical modeling of magnetic characteristics in SRMs, which is based on the two- dimensional (2-D) least squares technique. The computation results validated that the developed estimator can be used to accurately and fast compute static or dynamic torque if a limited number of static or dynamic magnetic characteristics are acquired by experiment or FE analysis. This paper provides a valuable torque estimator for performance prediction, design, and torque control of SRM drives. (4 pages)
Effect of Age on Ocular Microtremor Activity (2001)

These results suggest that different values of normality should operate for subjects over 60 years of age when considering the clinical application of OMT.
Abstract 21: Melting the Plastic Ceiling: Quantifying Resources for and Identifying Barriers to Women Seeking Academic Plastic Surgery Leadership Positions (2019)

PURPOSE: To quantify departmental resources available to female plastic surgeons and identify remaining barriers to advancement for women in academic plastic surgery. METHODS: Academic plastic surgery departments were identified and a female faculty member or male program director was selected. Representatives were surveyed on their department’s resources for promoting women leaders. An optional follow-up interview discussed current barriers to women seeking leadership positions. RESULTS: 49 of 93 survey recipients participated (52.7% response rate). Departments on average provided 2.69 of 11 resources (Table 1). Departments with female chairs provided 4.30 resources vs. 2.26 resources at departments with male chairs (p=0.014). Departments with female program directors provided 4.45 resources vs. 2.22 resources at departments with male program directors (p=0.006). Of the 49 survey respondents, 9 completed the interview (18.4% completion rate). The most frequently identified barriers to aspiring women leaders (Table 2) were opaque promotion criteria (cited by 66.7% of interviewees), compensation disparities (55.6%), faculty homogeneity (55.6%), and motherhood bias (55.6%). CONCLUSIONS: The presence of a female chair or program director is associated with a greater quantity of resources for promoting female leaders. Remaining barriers to women ascending to academic leadership include compensation and promotion disparities, faculty homogeneity, and motherhood bias.
Real‐Time Product Switching Using a Twin Catalyst System for the Hydrogenation of Furfural in Supercritical CO2 (2010)

„Warenautomaten“-Chemie: Mit einem Tandem-Flussreaktor-System gelingt die wahlweise Produktion von fünf Produkten aus einem einzigen bioerneuerbaren Rohstoff – Furfural (1) – in hoher Ausbeute. Der Wechsel in „Echtzeit“ zu einem beliebigen dieser Produkte erfordert nur eine Änderung der Reaktorbedingungen.
Magnetron Driven 'Q' Switched Cavity For Microwave Pulse Generation (1991)

An S Band microwave, laser triggered Q switched cavity operating at 100Hz prf is described. The input source is a commercial S Band magnetron giving 2MW at 2us pulse length. The maximum gain of the system has been observed as 40 and has yielded a peak power output of 40MW with a risetime of 2ns ad a duration of 12ns. Effects of input and output cavity Q and the use of Sulphur Hexafluoride (SF6) and other gases filling the cavity are discussed along with the possibility of multiple output cavities.
An Unbiased Oncology Compound Screen to Identify Novel Combination Strategies (2016)

Combination drug therapy is a widely used paradigm for managing numerous human malignancies. In cancer treatment, additive and/or synergistic drug combinations can convert weakly efficacious monotherapies into regimens that produce robust antitumor activity. This can be explained in part through pathway interdependencies that are critical for cancer cell proliferation and survival. However, identification of the various interdependencies is difficult due to the complex molecular circuitry that underlies tumor development and progression. Here, we present a high-throughput platform that allows for an unbiased identification of synergistic and efficacious drug combinations. In a screen of 22,737 experiments of 583 doublet combinations in 39 diverse cancer cell lines using a 4 by 4 dosing regimen, both well-known and novel synergistic and efficacious combinations were identified. Here, we present an example of one such novel combination, a Wee1 inhibitor (AZD1775) and an mTOR inhibitor (ridaforolimus), and demonstrate that the combination potently and synergistically inhibits cancer cell growth in vitro and in vivo This approach has identified novel combinations that would be difficult to reliably predict based purely on our current understanding of cancer cell biology. Mol Cancer Ther; 15(6); 1155-62. ©2016 AACR.
Neonatal Zika virus infection causes epileptic seizures, viral persistence and long-term behavioral impairment (2017)

Abstract A causal relationship between congenital Zika virus (ZIKV) exposure and microcephaly and other neurological disorders have been established, but long-term consequences of infection are still unknown. We evaluated acute and late neuropathological and behavioral consequences of ZIKV infection in a neonatal immunocompetent mouse model. ZIKV showed brain tropism, causing post-natal microcephaly and several behavioral dysfunctions. During the acute phase of infection, mice developed very frequent epileptic seizures, which are consistently reduced by TNF-α neutralization. Although adult animals recover from seizures, they become more susceptible to chemically-induced crises. Intriguingly, the virus remained actively replicating in adult animals, which show persistent necrosis and calcifications in the mice brain. Altogether the results reveal late consequences of neonatal ZIKV exposure and suggest the early inhibition of neuroinflammation as a potential treatment.
Effect of IBD medications on COVID-19 outcomes: results from an international registry (2020)

Combination therapy and thiopurines may be associated with an increased risk of severe COVID-19. No significant differences were observed when comparing classes of biologicals. These findings warrant confirmation in large population-based cohorts.MKH should be changed to MDK for co-last author line.
Regulation of Microfilament Reorganization and Invasiveness of Breast Cancer Cells by Kinase Dead p21-activated Kinase-1 (2000)

Stimulation of growth factor signaling has been implicated in the development of invasive phenotype and p21-activated kinase (PAK1) activation in human breast epithelial cancer cells. To further explore the roles of PAK1 in the invasive behavior of breast cancer cells, in the present study we investigated the influence of inhibition of PAK1 activity on the reorganization of cytoskeleton components that control motility and invasiveness of cells, using a highly invasive breast cancer MDA-MB435 as a model system. Our results demonstrate that overexpression of a kinase dead K299R PAK1 mutant leads to suppression of motile phenotypes as well as invasiveness of cells both in the absence or presence of exogenous heregulin-beta1. In addition, these phenotypic changes were accompanied by a blockade of disassembly of focal adhesion points, stabilization of stress fibers, and enhanced cell spreading and were dependent on the presence of the kinase dead domain but independent of the presence of the Rac/cdc42 intact (Cdc42/Rac interactive binding) domain of PAK1. We also demonstrated that in K299R PAK1-expressing cells, F-actin filaments were stabilized by persistent co-localization with the actin-binding proteins tropomyosin and caldesmon. Extension of these studies to invasive breast cancer MDA-MB231 cells illustrated that conditional expression of kinase-defective K299R PAK1 was also accompanied by persistent cell spreading, multiple focal adhesion points, and reduced invasiveness. Furthermore, inhibition of PAK1 activity in breast cancer cells was associated with a reduction in c-Jun N-terminal kinase activity, inhibition of DNA binding activity of transcription factor AP-1, and suppression of in vivo transcription driven by AP-1 promoter (known to be involved in breast cancer invasion). These findings suggest that PAK1 downstream pathways have a role in the development and maintenance of invasive phenotypes in breast cancer cells.
Standardized Ki67 Diagnostics Using Automated Scoring—Clinical Validation in the GeparTrio Breast Cancer Study (2014)

The computer-assisted Ki67 scoring approach presented here offers a standardized means of tumor cell proliferation assessment in breast cancer that correlated with clinical endpoints and is deployable in routine diagnostics. It may thus help to solve recently reported reliability concerns in Ki67 diagnostics.
Infected aneurysm after returning from Southeast Asia: think Burkholderia pseudomallei! (2019)

Melioidosis is a protean disease which is endemic to Southeast Asia and northern Australia. Here, we report a case of infected aortic aneurysm due to <i>Burkholderia pseudomallei</i> in an immunocompetent man 6 months after a trip to northern Malaysia. This patient initially received inappropriate surgical and antibiotic treatment, leading to a peri-prosthetic aortic infection with lumbar spondylitis and contiguous psoas muscle abscess. This case highlights the difficulty of diagnosing melioidosis given its diverse clinical manifestations and the limits of routine microbiological methods to identify <i>B. pseudomallei</i> Melioidosis should be considered a possible diagnosis in individuals with unexplained fever subsequent to travel in an endemic area.
A streptothricin-like antibiotic mixture, A-269A (and A-269A'). (1987)

A streptothricin-like antibiotic, A-269A (referred to as A-269A hereafter) was isolated from the culture broth of Streptomyces sp., strain No. A-269. In this paper, the characterization of the producer, and the production, isolation, physico-chemical properties and biological properties of A-269A are reported. The structure of the antibiotic was also examined by 1H NMR, 13C NMR and fast atom bombardment mass spectra studies. From the spectroscopic data, A-269A was assumed to be a mixture of antibiotic LL-BL 136 and an isomeric compound in which the carbamoyl group is substituted on C-12' hydroxyl instead of C-10 hydroxyl.
A scalable distance-1 vertex coloring algorithm for power-law graphs (2018)

We propose a distributed, unordered, label-correcting distance-1 vertex coloring algorithm, called Distributed Control (DC) coloring algorithm. DC eliminates the need for vertex-centric barriers and global synchronization for color refinement, relying only on atomic operations and local termination detection to update vertex color. We implement our DC coloring algorithm and the well-known Jones-Plassmann algorithm in the AM++ AMT runtime and compare their performance. We show that, with runtime support, the elimination of waiting time of vertex-centric barriers and investing this time for local ordering results in better execution time for power-law graphs with dense local subgraphs.
Physics-based multiple time-series univariate forecasting (2022)

The Koopman operator theory provides a recipe for data-driven analysis of dynamical systems. The forecasting problem addresses the future value estimation of an observation from its recent past. One common modeling approach is producing forecasts via modeling the data-generating process, where observations are a function of the state variables of the data-generating process. One major challenge to this is the lack of knowledge of the data-generating process. Delay embedding is a common approach in dynamical system analysis to approximate the state-space manifold from a few state value measurements. In this work, we propose a deep learning framework that employs delay embedding, and Koopman operator theory in the context of univariate forecasting to produce a long-term stable forecast. In this work, we empirically show the correctness of the proposed framework. Our study shows the proposed model can generalize across data-set and is capable of producing a stable long-range forecast.
Supplementary Data Method and Figures from Outcome-Related Differences in Gene Expression Profiles of High-Grade Serous Ovarian Cancers Following Neoadjuvant Chemotherapy (2023)

&lt;p&gt;Supplementary Figure 1: Log-transformed Quantile-Quantile plots of the Univariate Survival Analysis p-values. P-values derived from the univariate survival analysis of the effects of each individual gene was plotted for each fold in which the analysis took place. The horizontal line at 2.52 represents -log(0.003), which was the cutoff for variable selection in the final modeling of survival in the test cohort. Supplementary Figure 2: Abridged representation of the FOXM1 regulatory network. See references [2-5]&lt;/p&gt;
PUMP/PROBE MICROWAVE-OPTICAL DOUBLE RESONANCE (PPMODR) STUDY OF TUNGSTEN CARBIDE (WC) AND PLATINUM CARBIDE (PtC) (2012)

Author Institution: Department of Chemistry and Biochemistry; Arizona State University; Tempe, Arizona 85287-1604; U.S.A
A comparative NMR and molecular dynamics study of the conformations of bradykinin B1 and B2, B2, and B1-specific receptor antagonists B-9430, B-9436, and B-9858 (1997)

Extensive proton magnetic resonance experiments were carried out on three bradykinin peptide antagonists B-9430, B-9436, and B-9858 in aqueous solutions as well as in sodium dodecylsulphate micelles (B-9430 and B-9436) and CD3OH/H2O (60%/40%) mixtures for B-9858. All three peptides showed no observable secondary structure in aqueous solution. However, in their respective structure-inducing solvents, B-9430 (B1 and B2 receptor antagonist) and B-9436 (a B2 receptor antagonist) exhibit a type II beta-turn involving residues 2-5, and B-9430 also exhibits a type II' beta-turn involving residues 6-9 (in sodium dodecylsulfate micellar solutions), whereas B-9858, a B1-specific receptor antagonist, exhibits only a type II beta-turn involving residues 2-5 (in CD3OH/H2O solutions). Simulated annealing calculations on B-9858 confirm the experimental conclusions based on the nmr data. In addition, simulated annealing of the (2S, 3aS, 7aS)-octahydroindole-2-carboxylic acid (Oic residue), which is present in two of the three decapeptides studied, show that the one-chair conformation of the six-membered ring predominates, in agreement with the experimental data. The activities of these peptides are compared with their secondary structures and the specific receptor activity appears to depend on the presence of specific amino acid residues, such as N-(2-indanyl) glycine (Nig) and D[alpha-(2-indanyl) glycine] (D-Igl) as well as on elements of secondary structure.