gebhart/patrepeval huggingface dataset:
Dissecting the PRSS37 interactome and potential mechanisms leading to ADAM3 loss in PRSS37-null sperm (2021)

ABSTRACT A disintegrin and metalloproteinase 3 (ADAM3) is a sperm membrane protein critical for sperm migration from the uterus into the oviduct and sperm-egg binding in mice. Disruption of PRSS37 results in male infertility concurrent with the absence of mature ADAM3 from cauda epididymal sperm. However, how PRSS37 modulates ADAM3 maturation remains largely unclear. Here, we determine the PRSS37 interactome by GFP immunoprecipitation coupled with mass spectrometry in PRSS37-EGFP knock-in mice. Three molecular chaperones (CLGN, CALR3 and PDILT) and three ADAM proteins (ADAM2, ADAM6B and ADAM4) were identified to be interacting with PRSS37. Coincidently, five of them (except ADAM4) have been reported to interact with ADAM3 precursor and regulate its maturation. We further demonstrated that PRSS37 also interacts directly with ADAM3 precursor and its deficiency impedes the association between PDILT and ADAM3. This could contribute to improper translocation of ADAM3 to the germ cell surface, leading to ADAM3 loss in PRSS37-null mature sperm. The understanding of the maturation mechanisms of pivotal sperm plasma membrane proteins will pave the way toward novel strategies for contraception and the treatment of unexplained male infertility.
Radiation Effects in Type-Two Antimonide Superlattice Infrared Detectors (2009)

One-MeV proton irradiation of antimonide superlattice infrared detectors intended for use in space decreases the quantum efficiency, increases leakage and decreases the activation energy for carrier diffusion. Still, the devices show high radiation tolerance: The fluence at which noticable degradation is observed, 5 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">11</sup> H <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> /cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , is equivalent to about 1 Mrad(Si).
ChemInform Abstract: Samarium(II) Iodide Mediated Intramolecular Homolytic Substitution at Selenium: Preparation of 5‐Seleno‐D‐pentopyranose Sugars from Common Pentose Starting Materials. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Classification of Motor Control Difficulty using EMG in Physical Human-Robot Interaction (2020)

In physical human-robot interaction, a variable admittance/impedance controller is desired to adjust its controller parameters to enhance the collaboration by minimizing the human effort and maximizing the stability. In this paper, we propose a physiological monitoring approach based on electroencephalogram activities to classify the motor control difficulty and use that information for adjusting an admittance controller. We designed a physical human-robot interaction experiment where the human guides the robot's end-effector across four tasks with varying motor control difficulty. Each task is a combination of high/low damping and fine/gross motor control. During the experiments, we measure the muscle activation information in terms of surface electromyogram from eight channels. Two sets of features based on Riemann geometry and time domain (Hudgins' features) are extracted every 500 ms from the EMG data. A support vector machine classifier is trained on these features to estimate whether the existing admittance parameters are comfortable for the user else an increase/decrease of the damping is suggested. Riemann geometry-based features yielded higher accuracy (85.7%) than the Hudgins' features (69.1%) across 21 participants; however, the performance of these classifiers on the new sessions degraded to 63.1% and 54.5% respectively. To address this issue, we implemented a transfer learning approach using Riemannian features that improved the inter-session detection rate to 73.95%.
Atom-Efficient Metal-Catalyzed Cross-Coupling Reaction of Indium Organometallics with Organic Electrophiles (2001)

The novel metal-catalyzed cross-coupling reaction of indium organometallics with organic electrophiles is described. Triorganoindium compounds (R(3)In) containing alkyl, vinyl, aryl, and alkynyl groups are efficiently prepared from the corresponding lithium or magnesium organometallics by reaction with indium trichloride. The cross-coupling reaction of R(3)In with aryl halides and pseudohalides (iodide 2, bromide 5, and triflate 4), vinyl triflates, benzyl bromides, and acid chlorides proceeds under palladium catalysis in excellent yields and with high chemoselectivity. Indium organometallics also react with aryl chlorides as under nickel catalysis. In the cross-coupling reaction the triorganoindium compounds transfer, in a clear example of atom economy, all three of the organic groups attached to the metal, as shown by the necessity of using only 34 mol % of indium. The feasibility of using R(3)In in reactions with different electrophiles, along with the high yields and chemoselectivities obtained, reveals indium organometallics to be useful alternatives to other organometallics in cross-coupling reactions.
Infiltrating Mast Cell–Mediated Stimulation of Estrogen Receptor Activity in Breast Cancer Cells Promotes the Luminal Phenotype (2020)

Tumor growth and development is determined by both cancer cell-autonomous and microenvironmental mechanisms, including the contribution of infiltrating immune cells. Because the role of mast cells (MC) in this process is poorly characterized and even controversial, we investigated their part in breast cancer. Crossing C57BL/6 MMTV-PyMT mice, which spontaneously develop mammary carcinomas, with MC-deficient C57BL/6-Kit<sup>W-sh/W-sh</sup> (Wsh) mice, showed that MCs promote tumor growth and prevent the development of basal CK5-positive areas in favor of a luminal gene program. When cocultured with breast cancer cells <i>in vitro</i>, MCs hindered activation of cMET, a master regulator of the basal program, and simultaneously promoted expression and activation of estrogen receptor (<i>ESR1</i>/ER) and its target genes (<i>PGR, KRT8</i>/<i>CK8, BCL2</i>), which are all luminal markers. Moreover, MCs reduced <i>ERBB2</i>/HER2 levels, whose inhibition further increased <i>ESR1</i> expression. <i>In vivo</i> and <i>in silico</i> analysis of patients with breast cancer revealed a direct correlation between MC density and <i>ESR1</i> expression. In mice engrafted with HER2-positive breast cancer tumors, coinjection of MCs increased tumor engraftment and outgrowth, supporting the link between MCs and increased risk of relapse in patients with breast cancer. Together, our findings support the notion that MCs influence the phenotype of breast cancer cells by stimulating a luminal phenotype and ultimately modifying the outcome of the disease. SIGNIFICANCE: Mast cells impact breast cancer outcome by directly affecting the phenotype of tumor cells through stimulation of the estrogen receptor pathway.
Simplified Portable Bridge Weigh-in-Motion System Using Accelerometers (2017)

Monitoring traffic loads is crucial for effective steel bridge maintenance because fatigue damage in steel bridges is caused by the long-term cumulative effect of traffic loads. This article presents a simplified portable bridge weigh-in-motion (spBWIM) system consisting of only accelerometers, which are easy to install because they can be magnetically attached to a painted metal surface without removal of paint. The spBWIM system uses a single accelerometer for all traffic lanes to determine bridge displacement responses attributable to traveling vehicles and two accelerometers for each traffic lane to detect vehicle axles. Field measurements were performed using three different test trucks on an actual in-service bridge to study the effectiveness and accuracy of the proposed spBWIM system. The results show that the spBWIM system can be used to estimate gross vehicle weights (GVWs) to within an error of ±15.3% compared with static weighing using a truck scale. Based on the results, the authors believe that the spBWIM system can potentially be developed into a viable alternative to conventional BWIM systems that use strain gauges.
Identification of Early Represented Gluten Proteins during Durum Wheat Grain Development (2017)

The time course of biosynthesis and accumulation of storage proteins in developing grains of durum wheat (Triticum turgidum ssp. durum (Desf.) Husn.) pasta-quality reference cv. Svevo was investigated at the protein level for the first time. Seeds were harvested at key kernel developmental stages, namely, 3 (seed increase 3-fold in size), 5 (kernel development, water-ripe stage), 11 (kernel development, water-ripe stage), 16 (kernel full development, water-ripe stage), 21 (milk-ripe stage), and 30 (dough stage) days postanthesis (dpa). Gliadins and glutenins were fractionated according to their different solubility and individually analyzed after fractionation by reversed-phase high performance liquid chromatography and sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Proteins were identified by liquid chromatography-tandem mass spectrometry of proteolytic peptides. The α- and γ-gliadin were already detected at 3 dpa. The biosynthesis of high molecular mass glutenin Bx7 was slightly delayed (11 dpa). Most of the gluten proteins accumulated rapidly between 11 and 21 dpa, with a minor further increase up to 30 dpa. The expression pattern of gluten proteins in Triticum durum at the early stages of synthesis provides reference data sets for future applications in crop breeding and growth monitoring.
[Juvenile chronic arthritis. Double-blind study of the efficacy and tolerance of D-penicillamine]. (1985)

Seventy-four children with juvenile chronic arthritis were admitted to a 6-month multicentric double blind comparative study of the efficiency of D-Penicillamine or placebo. The results evaluated in 55 patients who completed the study, indicated an improvement in the total number of stiff joints and in the total index of severity measuring joint pain and inflammation. A significant reduction of the concurrent use of non steroidal antiinflammatory drugs was also observed. The tolerance was good except in two patients. Some children in the placebo group exhibited a definite improvement.
Chemical Composition and Biological Activity of Paris quadrifolia L. (2012)

A study of the components of Paris quadrifolia was undertaken to identify compounds with potential influence on cardiac cells, since previous reports suggested a cardiotoxic risk of this plant. Compounds isolated and identified included one new steroidal saponin, (23S,24S)-spirosta-5,25(27)-diene-1beta,3beta,21,23,24-pentol-1-O-beta-D-apiofuranosyl-(1-->3)-alpha-L-rhamnopyranosyl-(1-->2)-[beta-D-xylopyranosyl-(1-->3)]-beta-D-glucopyranoside 21-O-beta-D-apiofuranoside 24-O-beta-D-fucopyranoside (1), demonstrating quite unusual structural features, as well as the known compounds 26-O-beta-D-glucopyranosyl-(25R)-5-en-furost-3beta,17alpha,22alpha,26-tetraol-3-O-alpha-L-rhamnopyranosyl-(1-->4)-alpha-L-rhamnopyranosyl-(1-->4)-[alpha-L-rhamnopyranosyl--(1-->2)]-beta-D-glucopyranoside (2), pennogenin 3-O-alpha-L-rhamnopyranosyl-(1-->4)-alpha-L-rhamnopyranosyl-(1-->4)-[alpha-L-rhamnopyranosyl-(1-->2)]-beta-D-glucopyranoside (3), 7-O-beta-D-glucopyranosyl-kaempferol-3-O-beta-D-glucopyranosyl-(1-->2)-beta-D-galactopyranoside (4), kaempferol-3-O-beta-D-glucopyranosyl-(1-->2)-beta-D-galactopyranoside (5), 5-hydroxyecdysterone (6), and 20-hydroxyecdysone (7). The pennogenin derivative 3 showed strong cardiotoxic effects in an in vitro cellular model system, whereas the respective furostanol derivative 2 was inactive.
ECO-Fusion, integrated software for environmentally-conscious production (2002)

An integrated environmental software program called ECO-Fusion has been developed as a tool for support of environmentally-conscious production, in particular in relation to the manufacture of electronic products. When the environmental impact of manufacturing and use of an actual product needs to be determined, the main problems are description of product composition and product life-cycle, storage of these data, and correspondence of various environmental estimation techniques. To solve these problems, ECO-Fusion features product-centered description, an object-oriented product database, and multifaceted environmental evaluation. The product-centered description is created by using the input system, the product list window, the composition window, and the life-cycle flow window. Product composition is represented by a tree structure with a product root in the composition window, and product life-cycle flow is represented by a coupled-tree structure with a product root in the life-cycle flow window. This input system allows simple modeling of complicated compositions and life-cycles for actual products. The object-oriented product database is suitable for storing the relationships of components, attributes of the components, relationships between processes, and attributes of the processes. Multifaceted evaluation is achieved by implementing three evaluation techniques: environmental product assessment, life-cycle assessment (LCA), and assembly/disassembly evaluation. In environmental product assessment, a product is compared with a reference product using and about 30 criteria on an environmental checksheet.
Chiral Phosphoric Acid-Catalyzed Remote Control of Axial Chirality at Boron–Carbon Bond (2021)

The previously elusive catalytic enantioselective construction of axially chiral B-aryl-1,2-azaborines with a C-B stereogenic axis has been realized through a chiral phosphoric acid-catalyzed desymmetrization strategy reported herein. The electrophilic aromatic substitution reaction of 3,5-disubsituted phenols with diazodicarboxamides could afford these axially chiral structures in good efficiency with excellent enantiocontrol. The efficient long-range stereochemical control is achieved by multiple well-defined H-bonding interactions between chiral phosphoric acid and both substrates. Meanwhile, the reaction duration could be markedly shortened with weakly acidic N-H in 1,2-azaborine acting as H-bond donor. The scalability of the reaction and facile cleavage of the N-N bond in the product further demonstrated the practicality of this method.
Comparative Serological Studies Between a Newly Isolated Halophilic Leptospira and Two Other Leptospiras Isolated from Brackish Water (1974)

Microbiology Society journals contain high-quality research papers and topical review articles. We are a not-for-profit publisher and we support and invest in the microbiology community, to the benefit of everyone. This supports our principal goal to develop, expand and strengthen the networks available to our members so that they can generate new knowledge about microbes and ensure that it is shared with other communities.
Blackfingers A Sophisticated Hand Prothesis (2003)

Abstract: Our goal is to develop the low level control system for an artificial hand ”Blackfingers”. Blackfingers was thought to have two main applications: as humanoid robot’s hand or as a human hand prothesis. In this last application our intent is to realize a device more sophisticated respect the actual commerce prothesis. Also in our intention is to use some biological paradigms to create a human like reflex control easy to be interfaced also with the human nervous system. In this paper we illustrate the properties and the morphology of a human like neural reflex controller, used to set the stiffness and joint positions of our artificial hand. In particular we explain, by simulations results, its ability to emulate the myotatic human reflex, and its capacity to learn in real time the best control strategy.
Generating Natural Answers by Incorporating Copying and Retrieving Mechanisms in Sequence-to-Sequence Learning (2017)

Generating answer with natural language sentence is very important in real-world question answering systems, which needs to obtain a right answer as well as a coherent natural response.
Structural components of alginic acid. I. The crystalline structure of poly‐β‐D‐mannuronic acid. Results of X‐ray diffraction and polarized infrared studies (1973)

Abstract A Structure determination of the naturally occuring marine algal polysaccharide poly‐β‐ D ‐mannuronic acid is described. The structure consists of 1e → 4e linked D ‐mannuronic acid chains with the monosaccharide units in the C1 chair conformation. The X‐ray fiber diffraction photograph obtained from bundles of fibers prepared from Fucus vesiculosus has been indexed to an orthorhombic unit cell in which a =7.6 Å, b (fiber axis) = 10.4 Å, c = 8.6 Å, the unit cell containing two disaccharide chain segments with space group P2 1 2 1 2 1 . A sheet‐like structure involving one intra‐chain, one intra‐sheet, and one inter‐sheet hydrogen bond per monosaccharide is proposed. Features of the chain‐packing arrangement are compared with mannan.
Hybrid-Integrated Polarization Diverse Coherent Receiver Based on Polymer PLC (2012)

A dual-polarization coherent receiver using polymer planar lightwave circuit technology is demonstrated for the first time. It comprises optical 90 hybrids on the basis of polymer waveguides, polarization beam-splitting thin-film elements, and photodetectors made of InGaAsP/InP. The chip size fits into the existing receiver package standards. The receiver assembly shows a high polarization extinction ratio (>;25 dB over C-band) and is successfully operated in system experiments with 16-quadrature-amplitude modulation and quadrature phase-shift keying modulation up to 112 Gb/s.
Influence of the Annealing Process Parameters in the Production of New Short‐Fibre‐Reinforced C/C‐SIC Composites (2017)

This chapter examines a direct relationship between the used parameters of annealing process and the degree of cure as well as the formation of porosity through an experiment. A new short-fiber reinforced C/C-SiC composite was developed by using the liquid silicon infiltration (LSI) process, which comprised three processing steps. A carbon-fiber-reinforced plastic (CFRP) composite was fabricated. The shaping of this composite was realized by a thermoset injection molding process. The CFRP composite was converted into a porous C/C composite by pyrolysis. Liquid silicon was infiltrated to form a dense C/C-SiC composite. An additional heat treatment of the cured CFRP composite completes the crosslinking of the polymer and thus a higher carbon yield was achieved. In addition, the microstructure along the whole process route was strongly influenced. The chapter also discusses the influence of the annealing parameters, including characterization of the starting materials as well as the microstructures of the composites.
Portal Venous and Systemic Endotoxaemia in Patients without Liver Disease and Systemic Endotoxaemia in Patients with Cirrhosis (1976)

Prytz, H., Holst-Christensen, J., Korner, B. & Liehr, H. Portal venous and systemic endotoxaemia in patients without liver disease and systemic endotoxaemia in patients with cirrhosis. Scand. J. Gastroent. 1976, 11, 857-863Systemic endotoxaemia without evidence of gram-negative bacterial infection occurs in liver diseases in man. The endotoxaemia is probably due to impaired hepatic clearance of endotoxin absorbed from the gastrointestinal tract, but portal venous endotoxaemia has never been reported in man. By means of the limulus gelation test, portal venous blood from 21 patients without parenchymal liver disease and arterial blood from 21 patients without parenchymal liver disease and 31 patients with cirrhosis was examined for endotoxin. Portal venous endotoxaemia was found in 9 of 21 samples and systemic endotoxaemia was found in 2 of 21 samples from patients without liver disease. Systemic endotoxaemia in cirrhosis occurred with a frequency of 15/31. No relationship to gram-negative bacteraemia was found. Leuco-cytosis was only seen in endotoxin-positive patients with cirrhosis. In cirrhosis higher levels of E. coli 0 antibodies were found in endotoxin-positive than in endotoxin-negative patients, supporting the view that the limulus gelation test specifically detects endotoxin (i.e. E. coli 0 antigen). The study suggests that endotoxin is a normal constituent of portal venous blood in man. The normal human liver clears endotoxin from the portal venous blood. This effect is diminished in cirrhosis, most probably owing to decreased phagocytic function of the liver. The increased humoral immune response in cirrhosis may be related to spillover of endotoxin from the liver.
Inhalation Toxicity of GF Vapor in Rats as a Function of Exposure Concentration and Duration and Its Potency Comparison to GB (2003)

Abstract : The inhalation toxicity of cyclohexyl methylphosphonofluoridate (GF) was examined in male and female Sprague-Dawley rats exposed by whole-body in a dynamic 750-L chamber. The objectives of this study were to 1) validate vapor detection methods for GF, starting in the lethal to near-lethal concentration range; 2) examine dose-response effects of inhaled GF vapor, analyze the relationship between concentration (C) and exposure duration (t) in determining probability of lethality; and 3) establish a lethal potency ratio between GF and the more volatile agent sarin (GB). The GF vapor concentrations were generated for exposure times of 10, 60, and 240 min. Dose- response curves with associated slopes were determined by the Bliss probit method. Concentration-exposure time values for lethality in 50% of the exposed population (LCt50) were calculated for 24-hr and 14-day post exposure periods for 10-, 60-, and 240-min exposures. At longer exposure durations, the LCt50 for GF was less than for GB, but at shorter exposure durations, the LCt50 for GF was more than for GB. Empirical models, consisting of the toxic load model plus higher order terms, were fit to the data to test the adequacy of the model and to identify statistically significant patterns.