gebhart/patrepeval huggingface dataset:
Innenrücktitelbild: Bispericyclic Diels–Alder Dimerization of ortho‐Quinols in Natural Product (Bio)Synthesis: Bioinspired Chemical 6‐Step Synthesis of (+)‐Maytenone (Angew. Chem. 27/2021) (2021)

Von der Kreidetafel mit der bispericyclischen Diels-Alder-Reaktion von ortho-Chinolen zum Labor mit dem (+)-Ferruginol-Substrat und einem chiralen Bisiodyl-Reagenz im Kolben: Die so erzeugten ortho-Chinol-Diastereomere verbinden sich paarweise zu einem C2-symmetrischen Übergangszustand, in dem [4+2]- und [2+4]-Prozesse äquivalent sind, wie Laurent Pouységu, Stéphane Quideau et al. im Forschungsartikel auf S. 15094 berichten. Unter hohem Druck führt dieser Übergangszustand zum Produkt, (+)-Maytenon, hier im Hintergrund dargestellt. Grafik: Jean Ung@SQuideau Lab.
Mnemosyne (2011)

New storage-class memory (SCM) technologies, such as phase-change memory, STT-RAM, and memristors, promise user-level access to non-volatile storage through regular memory instructions. These memory devices enable fast user-mode access to persistence, allowing regular in-memory data structures to survive system crashes. In this paper, we present Mnemosyne, a simple interface for programming with persistent memory. Mnemosyne addresses two challenges: how to create and manage such memory, and how to ensure consistency in the presence of failures. Without additional mechanisms, a system failure may leave data structures in SCM in an invalid state, crashing the program the next time it starts. In Mnemosyne, programmers declare global persistent data with the keyword "pstatic" or allocate it dynamically. Mnemosyne provides primitives for directly modifying persistent variables and supports consistent updates through a lightweight transaction mechanism. Compared to past work on disk-based persistent memory, Mnemosyne reduces latency to storage by writing data directly to memory at the granularity of an update rather than writing memory pages back to disk through the file system. In tests emulating the performance characteristics of forthcoming SCMs, we show that Mnemosyne can persist data as fast as 3 microseconds. Furthermore, it provides a 35 percent performance increase when applied in the OpenLDAP directory server. In microbenchmark studies we find that Mnemosyne can be up to 1400% faster than alternative persistence strategies, such as Berkeley DB or Boost serialization, that are designed for disks.
Percutaneous Sacroiliac Screw Technique (2016)

Remembering that preoperative planning, surgical indications, and fracture reduction are paramount for this procedure, presented here is our technique for performing percutaneous sacroiliac screws, both transiliac-transsacral and sacral style. A combination of video, still pictures, and fluoroscopy images will guide the viewer through the process we routinely use highlighting specific details. Patient positioning and intraoperative fluoroscopy imaging are critical to a successful procedure. Although inlet and outlet films remain important, we find the procedure best started on the lateral sacral view to reduce the need for start site, trajectory, and imaging position changes during the case. A cannulated pig sticker (drill guide) used with long drill tip guide wires provide improved manual control to both finding a good start site and directing the trajectory. For patient safety, sacral anatomy and safe zones are discussed as well. Using these technical points will help make this a successful procedure.
Laser Sintering of Pine/Polylatic Acid Composites (2019)

A new powder feedstock composed of sustainable and degradable biomass composite material was proposed for laser sintering technology in this research. This biomass mixture, abbreviated P-PLA, is made up of mechanically mixed polylactic acid (PLA) powder and pine powder. The proper processing parameters were determined based on the component thermal behavior and laser sintering testing: processing temperature 130-135°C, laser power 20-24 W, scan spacing 0.1-0.2 mm, scan speed 1.6-2.2 m/s and layer thickness 0.2mm. Laser-sintered P-PLA parts exhibited much better mechanical properties compared with pine/polyethersulfone copolyester (PCoPES) wood-plastic composite, with tensile strength 34-200% higher and flexural strength 92- 246% higher than values for laser-sintered P-CoPES. Results reveal that pine powder loading can reduce the shrinkage and deformation of laser-sintered P-PLA parts. Shrinkage decreased from 4% to 0.31-2.27% in the XY plane and from 3.25% to 0.13-2.25% in the Z direction.
Supplementary Table 3 from Genome-Wide CpG Island Profiling of Intraductal Papillary Mucinous Neoplasms of the Pancreas (2023)

&lt;p&gt;XLS file - 461K&lt;/p&gt;
A Case of Pleomorphic Adenoma Originating from the Nasal Cavity (2017)

Pleomorphic adenomas most commonly arise in the major salivary glands, and only rarely in the nasal cavity. We reported herein on a case of a pleomorphic adenoma originating from the nasal septum.
Laser Voltage Imaging: A New Perspective of Laser Voltage Probing (2010)

Abstract Laser Voltage Imaging (LVI) is a new application developed from Laser Voltage Probing (LVP). Most LVP applications have focused on design debug or design characterization, and are seldom used for global functional failure analysis. LVI enables the failure analysis engineer to utilize laser probing techniques in the failure analysis realm. In this paper, we present LVI as an emerging FA technique. We will discuss setting up an LVI acquisition and present its current challenges. Finally, we will present an LVI application in the form of a case study.
Optimizing vehicle to grid electric energy system with new technologies (2015)

The Electric Vehicles can enhance their positive contribution to the energy economy with a smart integration in the electrical network and an appropriate design, use oriented. The energy storage system design and consequently the integrated vehicle structure is to be driven by the predicted use, with regard to the charging potential over the operational mission. The frequency of the opportunistic charging during the daily mission is a factor, that can be considered in the appropriate sizing of the on-board energy storage design. The strategic location of the charging ports, the interactive vehicle-infrastructure communication and the easiness of charging procedure can be taken as a reference for appropriate sizing of the storage system, in terms of energy availability, weight and the other related parameters impacting the relevant energy life cycle figure. The evolution of the technology concept of magnetic flux application in the contactless energy transfer with the use of resonant circuits has brought to new technical solutions, which can offer a flexible and user friendly vehicle - infrastructure interface for the various modes of operation of the electric vehicles, static and dynamic. The wireless dynamic power transfer can offer the means to reduce significantly the on-board energy storage system requirements. Trade off opportunities can be considered between various elements from vehicle and infrastructure size, technical and economical and for the grid side management as well. Grid to vehicle interaction is a multi-aspect matter addressed by European Projects such as FABRIC and EV-CONNECT.
Real-time evaluation of human secretin receptor activity using cytosensor microphysiometry (1999)

Human secretin receptor is a G protein-coupled receptor that is functionally linked to the cAMP second messenger system by stimulation of adenylate cyclase. To functionally characterize the receptor and evaluate its signal transduction pathway, the full-length human secretin receptor cDNA was subcloned into the mammalian expression vector pRc/CMV and expressed in cultured CHO cells. Intracellular cAMP accumulation of the stably transfected cells was measured by a radioimmunoassay (RIA), while the extracellular acidification rate was measured by the Cytosensor microphysiometer. Human secretin and biotinylated human secretin were equipotent in both assays in a dose-dependent manner. The EC50 values of stimulating the intracellular cAMP accumulation and the extracellular acidification rate were 0.2-0.5 nM and 0.1 nM, respectively, indicating that microphysiometry is more sensitive than the cAMP assay in monitoring ligand stimulation of the human secretin receptor. The secretin-stimulated response could be mimicked by forskolin and augmented by the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine, indicating that the extracellular acidification response is positively correlated with intracellular cAMP level. The response could be abolished by the protein kinase A inhibitor H-89, suggesting that protein kinase A plays an essential role in the intracellular signaling of the receptor. Upon repeated stimulation by the ligand, the peak acidification responses did not change significantly at both physiological (0.03 nM and 3 nM) and pharmacological (0.3 microM) concentrations of human secretin, suggesting that the human secretin receptor did not exhibit robust homologous desensitization.
Adaptive temporal interpolation using bidirectional motion estimation and compensation (2003)

This paper concerns the issue of motion compensated interpolation for frame rate up-conversion. For each pair of temporally adjacent frames, both forward and backward motion estimation is conducted with a correlation constraint imposed upon block-based motion vectors. The fact that spatially adjacent pixels in a picture exhibit high correlation is exploited for adaptive refinement. It takes advantage of the complementary frames that are compensated using forward and backward motion estimates. Simulation results demonstrate the performance of the proposed technique.
Time interval from primary melanoma to first distant recurrence in relation to patient outcomes in advanced melanoma (2023)

Since the introduction of BRAF(/MEK) inhibition and immune checkpoint inhibition (ICI), the prognosis of advanced melanoma has greatly improved. Melanoma is known for its remarkably long time to first distant recurrence (TFDR), which can be decades in some patients and is partly attributed to immune-surveillance. We investigated the relationship between TFDR and patient outcomes after systemic treatment for advanced melanoma. We selected patients undergoing first-line systemic therapy for advanced melanoma from the nationwide Dutch Melanoma Treatment Registry. The association between TFDR and progression-free survival (PFS) and overall survival (OS) was assessed by Cox proportional hazard regression models. The TFDR was modeled categorically, linearly, and flexibly using restricted cubic splines. Patients received anti-PD-1-based treatment (n = 1844) or BRAF(/MEK) inhibition (n = 1618). For ICI-treated patients with a TFDR <2 years, median OS was 25.0 months, compared to 37.3 months for a TFDR >5 years (P = .014). Patients treated with BRAF(/MEK) inhibition with a longer TFDR also had a significantly longer median OS (8.6 months for TFDR <2 years compared to 11.1 months for >5 years, P = .004). The hazard of dying rapidly decreased with increasing TFDR until approximately 5 years (HR 0.87), after which the hazard of dying further decreased with increasing TFDR, but less strongly (HR 0.82 for a TFDR of 10 years and HR 0.79 for a TFDR of 15 years). Results were similar when stratifying for type of treatment. Advanced melanoma patients with longer TFDR have a prolonged PFS and OS, irrespective of being treated with first-line ICI or targeted therapy.
Amorphous Al-based Thick Sheets Produced by Rapid Solidification of Supercooled Liquid Droplets (1990)

Al84Ni10Mm6 (Mm=mischmetal) amorphous sheets with a maximum thickness of 7.0 mm were produced by the two-stage quenching technique consisting of high-pressure argon atomization and the subsequent incremental impact deposition on a rotator. The amorphous sheets had a thickness of 0.1 to 7.0 mm and an average width and length of 40 and 100 mm, respectively, and the thickness was controlled by changing the amount of the molten alloy in one ejection. The formation of an amorphous sheet with a large thickness up to 7.0 mm is quite different from the result by melt spinning that the amorphous ribbon is formed in the thickness range below about 0.13 mm and is thought to result from an incremental deposition at an interval of the order 10−3 s of the supercooled liquid droplets with high kinetic energies produced by high-pressure gas atomization. The glass transition and crystallization behavior remained unchanged over the entire thickness range of 0.1 to 7.0 mm and were the same as that of the melt-spun ribbon, but the density and hardness of the sheets were slightly lower than those of the ribbon probably because of the inclusion of pores. The thermal stability allows us to conclude that there is no distinct difference in amorphicity between the sheet with a thickness of 7.0 mm and the ribbon with a thickness of 0.02 mm. It is concluded therefore, that the present two-stage quenching technique provides an appropriate cooling condition for the formation of an amorphous thick sheet.
Double-clad hypocycloid core-contour Kagome hollow-core photonic crystal fiber (2018)

We report on the design and fabrication of the first double-clad hypocycloid core-contour Kagome fiber optimized for guidance in air-core at 1µm via Inhibited-Coupling and in a cladding silica ring via total-internal-reflection.
A majority rules approach to data mining (2002)

Knowledge discovery in databases (KDD) offers a methodology for developing tools to extract meaningful knowledge from large volumes of data. We propose a generalized KDD model for supervised training. A main step in this process, data mining, involves the creation of a classification structure that is representative of the concept classes identified in the data set. Data mining incorporates learning which may be supervised or unsupervised and often uses statistical as well as heuristic (machine learning) techniques. Previous research has shown that different supervised models perform better under certain conditions. We tested the extent of overlap of instance classifications between five supervised models in two real world domains. Experimental results showed that in one domain all five models classified 75.8% of the instances identically, correct or incorrect. In the second domain, the corresponding figure was 63.3%. The amount of agreement between models can be used to help determine the nature of the domain and the applicability of a supervised learning approach. We extend the above experimental result and propose a multi model majority rules (MR) data mining technique to learn about the nature of a given domain. We conclude with directions for future work.
Lung Nodules: Improved Wire for CT-guided Localization (1999)

The authors designed three localization wires that increase the utility of percutaneous localization of lung nodules performed in conjunction with video-assisted thorascopic resection. In 17 patients, the custom-made wires dislodged less frequently than did commercially available wires (two of 11 vs three of six, respectively) while allowing the surgeon to apply gentle retraction pressure, which aided the resection.
The Effect of Propofol on Oxidative Stress in Platelets from Surgical Patients (1999)

We investigated the changes in oxidative stress in platelets from surgical patients anesthetized with propofol. We studied 60 surgical patients (ASA physical status I and II) and 12 healthy volunteers. The patients were divided into three groups: anesthesia induced with an IV bolus dose of 4 mg/kg thiopental; anesthesia induced with an IV bolus dose of 2 mg/kg propofol; and total IV anesthesia (induction with propofol 2 mg/kg, infusion with propofol 10 mg/kg during the first 10 min, then 8 mg/kg for 10 min, and 6 mg/kg during the rest of the operation). Healthy volunteers were given an IV bolus dose of 10% fat emulsion (Intralipid). We measured the following variables in platelets: thiobarbituric acid reactive substances content, glutathione content, and glutathione peroxidase, reductase, and transferase activities. Thiopental did not modify any of the variables. Propofol decreased thiobarbituric acid reactive substances production by 25.7% and increased total glutathione content by 24.6%. The percentage of glutathione in oxidized form was 29.5% smaller in patients anesthetized with propofol. Glutathione peroxidase activity was 28.3% less, glutathione transferase was 44.5% more, and glutathione reductase was not significantly different. Intralipid had no effect on any of the variables. After infusion of propofol for 1 h, the effects were, in qualitative terms, the same as those seen after an initial bolus dose. In conclusion, our findings show that propofol has an antioxidant effect in humans. This effect may be beneficial in patients who have diseases in which free radicals play an important role. Implications This study demonstrates that propofol inhibits cellular oxidative damage, measured in platelets from surgical patients. Neither thiopental nor the fat emulsion (Intralipid) showed any effect. Moreover, propofol increased the antioxidant defense of glutathione. This could be applied in the protection of tissues from ischemic damage.
FR901724, a Novel Anti-human Immunodeficiency Virus (HIV) Peptide Produced by Streptomyces, Shows Synergistic Antiviral Activities with HIV Protease Inhibitor and 2',3'-Dideoxynucleosides. (1996)

A novel tricyclic 21-amino-acid peptide, FR901724, was isolated from the cultured broth of Streptomyces sp. No. 73264. This peptide appears to possess potent anti-human immunodeficiency virus (HIV) activity in vitro and might represent a lead to a new class of anti-HIV agents; it qualifies as an HIV-cell fusion inhibitor because of its weak inhibition of virus-cell binding and strong inhibition of syncytium formation. From the time-of-addition experiments, the mode of action of FR901724 was found to definitely differ from that of KNI-272, a peptide mimetic allophenylnorstatine-derivative HIV protease inhibitor. FR901724 appears to interact with a stage of the virus replicative cycle that may well correspond to virus-cell fusion. We also found that FR901724 was synergistic or had a strong tendency toward synergism when combined with other antiviral drugs, such as KNI-272, AZT, ddI and dextran sulfate.
<title>Four-element fiber grating sensor array with phase-sensitive detection</title> (1994)

A four element, time-division multiplexed, fiber grating sensor array operating between the wavelengths of 1280 and 1310 nm was constructed and tested. The array consists of a 1300 nm edge-emitting LED which illuminates four gratings spaced five meters apart. Each grating in the array reflects a spectrally narrow-band (0.2 - 0.5 nm) wavelength region. Measurand- induced changes in the grating period change the wavelength of the light reflected by each grating. The wavelength shifts are converted to phase changes by routing the reflected signal through a nearly path balanced fiber Mach Zehnder interferometer. The minimum detectable strain was measured to be as low as 2 nanostrain/(root)Hz for the frequencies between 10 and 100 Hz.
PANDEMIA POR COVID19: OTRAS CONSECUENCIAS (2021)

Objetivo: Describir la evolucin de la demanda en los servicios de urgencias, y los ingresos hospitalarios subsiguientes, en el rea mdica de un hospital general durante las fases iniciales de la pandemia por COVID19 y tras la declaracin del estadio de alarma. Mtodos: Estudio observacional de todas las visitas al Servicio de Urgencias de adultos, y de todos los ingresos en los servicios mdicos que se generaron, entre los das 1 y 31 de marzo de los aos 2017,
Generation of the bioactive kallikrein-derived fragment, C3d-k, by HANE-plasma. (1985)

Recent studies have concluded that after complement activation the final physiologic degradation products of C3 are C3c and the fragment of relative molecular mass (Mr) 42,000 which contains the C3d and C3g domains and was therefore named C3d,g. Using fluorescent labelled C3b as a substrate, we have determined the putative C3d,g ('C3d,g') producing activity of both normal and hereditary angioneurotic oedema (HANE) plasmas. In normal plasmas, the rate of production of C3d,g was 1.0 +/- 0.2 X 10(-10) mol/ml/h and this activity was blocked by antibodies to I. In contrast, HANE, plasmas (deficient in C1INH) showed more than twice as much 'C3d,g' production as normal plasmas and both antibodies to I and kallikrein were required to inhibit this activity. Because of this result, a more sensitive gel system was employed to detect the Mr 42,000 peptide and two 'C3d,g' fragments of approximately equal intensity with Mr of 42,000 and 43,000 were defined. Incubation of purified kallikrein with labelled iC3b produced a C3d,g-like fragment, C3d-k, that aligned with the band of 43,000 Mr generated in HANE plasma. These results indicate that HANE plasma, in contrast to normal plasma, generates the bioactive C3d-k fragment. C1INH blocks the activities of kallikrein and C1s, and C3d-k generation in HANE plasma is probably secondary to the proteolytic activity of kallikrein.
Mechanism involved in the systemic suppression of antigen-presenting cell function by UV irradiation. Keratinocyte-derived IL-10 modulates antigen-presenting cell function of splenic adherent cells. (1994)

Exposure to UV radiation suppresses tumor rejection and delayed-in-time hypersensitivity reactions and depresses splenic APC function. Because almost all of the UV radiation is absorbed in the upper layers of the skin, it appears unlikely the direct irradiation of APC can account for the impaired ability of splenic adherent cells to present Ag after total-body UV exposure. Because UV-irradiated keratinocytes release IL-10, and in light of the well-documented effects of IL-10 on Ag presentation, we tested the hypothesis that keratinocyte-derived IL-10 is responsible for the systemic impairment of APC function following UV exposure. Injecting supernatants from UV-irradiated keratinocytes suppressed the ability of splenic adherent cells to present Ag. Treating the supernatants with anti-IL-10 mAb neutralized the suppressive effect. Similarly, when splenic adherent cells were isolated from mice exposed to UV radiation, APC function was suppressed. Injecting the UV-irradiated animals with anti-IL-10 restored APC function. In addition, spleen cells from UV-irradiated mice did not efficiently present Ag to Th1 clones, and injecting anti-IL-10 after UV exposure restored APC function. The reverse was observed when spleen cells from UV-irradiated mice were used to present Ag to Th2 clones; in which case, UV exposure enhances APC function, and anti-IL-10 reverses this effect. These findings suggest that UV-induced, keratinocyte-derived IL-10 can modulate splenic APC function.
Gene expression of TLR homologues identified by genome-wide screening of the earthworm Dendrobaena veneta (2014)

TLRs represent one of the most important components of innate immunity. Currently, these receptors have been extensively studied in vertebrates and insects, but our knowledge for annelids is very limited. Therefore, the aim of our study was to identify earthworm TLR homologs by genome-wide screening, and to determine the expression of candidate genes as a response to Gram-positive and Gram-negative bacteria. Using a combination of deep pyrosequencing and quantitative PCR we found six candidate genes, for which all were expressed in Dentrobaena veneta. Two of the candidates showed significant response to bacterial exposure. In conclusion, TLRs seem to have a role in earthworm immunology.
Polymicrobial Amniotic Fluid Infection withMycoplasma/Ureaplasmaand Other Bacteria Induces Severe Intra-Amniotic Inflammation Associated with Poor Perinatal Prognosis in Preterm Labor (2015)

Our newly established PCR method is useful for detecting IA microorganisms. Polymicrobial infection with Mycoplasma/Ureaplasma and other bacteria induces severe IA inflammation associated with poor perinatal prognosis in PTL.