gebhart/patrepeval huggingface dataset:
Predicting Post-Discharge Community Violence in England and Wales Using the HCR-20 V3 (2014)

Structured guidelines are fundamental for risk assessment, formulation and decision-making in medium secure forensic psychiatric services in the UK. The most commonly used guideline for violence risk assessment in the UK is the HCR-20, so it is important that the new version of the HCR-20 (HCR-20 V3 ) is validated in UK samples. The aims of this study were to investigate if the HCR-20 V3 has satisfactory interrater reliability and predictive validity for community violence. A prospective confidential inquiry design was used. The HCR-20 V3 demonstrated very good inter-rater reliability and significantly predicted community violence at six and twelve months post-discharge, with ROC AUCs of .73 and .70 respectively. Implications for future research and practice are discussed.
Mode-chart calculation for dielectric- and conductor-loaded resonators using modal extraction and FDTD (1999)

Mode charts have been extracted for dielectric resonators in cylindrical and rectangular cavities and conductor-loaded planar cavities using the rectangular coordinate FDTD algorithm. A modal extraction procedure is applied to obtain the time-domain samples, and the matrix-pencil method is applied to these samples to obtain the resonant frequency values. The transverse symmetry planes of the modes have also been exploited in order to control the modes the resonator will support, as well as to reduce memory and computation requirements. ©1999 John Wiley & Sons, Inc. Microwave Opt Technol Lett 21: 405–411, 1999.
On the Use of CMOS 0n-Chip Mechanical Devices for Spectral Analysis (2002)

International audience
Modified Mesoporous Silica for Efficient Siloxane Capture (2016)

In this study, octamethylcyclotetrasiloxane (D4) was removed by using a novel modified solid adsorbent of mesoporous silica. The adsorbent was synthesized using inverse micelles with some modifications in the synthesis process (temperature of gelation) and in the post treatment conditions (calcination temperature and heating rate) with a concomitant improvement of D4 uptake. This is the first report on regulating the textural properties of the mesoporous silica material UCT-14 to develop an active silica adsorbent. These adjustments resulted in an increase of the silica surface area from 391 to 798 m(2)·g(-1), which leads to a high capacity (686 mg·g(-1)) of D4-capture for the silica synthesized at 80 °C, calcined at 450 °C with the heating rate of 100 °C·min(-1) (Si-Syn80). This adsorbent showed comparable adsorption performance with the widely used commercial silica gel under dry and humid condition. Recyclability tests on the commercial silica gel and mesoporous silica synthesized at 120 °C and calcined at 450 °C with a heating rate of 100 °C·min(-1) (called Si-Syn120 or Si-450 or Si-100 °C·min(-1)) indicated that the Si-Syn120 (capacity drop 10%) is more efficient than silica gel (capacity drop 15%) after three cycles. Although, the presence of moisture (25%) in the nitrogen gas stream led to capacity reduction in both Si-Syn120 and commercial silica gel, the modified UCT-14 shows slightly better resistance to humid condition.
Formation of biologically active peptides (1980)

Many small biologicaly active peptides are derived from larger precursor forms which fulfil a variety of roles in the synthesis, segregation and intracellular migration of secretory products. Limited proteolysis may occur at several stages during this process, giving rise to products that are either degraded (e.g. the prepeptides) or discharged coordinately from their cells of origin during exocytosis (e.g. insulin and C-peptide). Molecular defects have recently been found to occur at cleavage sites in proinsulin as well as in other proproteins, and these point mutations may, in some instances, be responsible for familial metabolic disorders. The nature and cell specificity of the proteolytic enzymes involved in the conversion of the various precursor forms remains unresolved. Recent studies in our laboratory have led to the identification of precursors of glucagon and somatostatin in rat islets of Langerhans. Analysis of tryptic maps of these precursors has shown that a trypsin-like enzyme would be sufficient to cleave the C-terminally located somatostatin sequence from its precursor (relative molecular mass 12,500), but that both trypsin-like and carboxypeptidase B-like enzymes would be necessary to cleave the internal glucagon sequence from its prohormone (relative molecular mass 18,000). Molecular cloning techniques have provided valuable new approaches to analysing the structures of a variety of precursor forms, including those for insulin, gastrin, growth hormone, adrenocorticotropic hormone and the endorphins, and in the future will undoubtedly shed more light on the structures of their chromosomal genes, the mechanisms regulating their expression, and their evolutionary origins.
A comparative analysis of OTF, NPS, and DQE in energy integrating and photon counting digital x‐ray detectors (2010)

This article develops analytical models of OTF, NPS, and DQE for energy integrating and photon counting digital x-ray detectors. While many subtleties of real imaging systems have not been modeled, this work is illustrative in demonstrating an additive source of white noise in photon counting detectors which has not yet been described in the literature. One benefit of this analysis is a framework for determining the average secondary quanta that an energy integrating detector must produce for each x ray to have superior DQE to competing photon counting technology.
Timing of gestational exposure to Zika virus is associated with postnatal growth restriction in a murine model (2018)

These findings demonstrate that postnatal effects of infection occurring at single time points continue to be detrimental to offspring in the postnatal period in a subset of littermates and subject to a window of gestational susceptibility coinciding with placentation. This model recapitulates frequently encountered clinical scenarios in nonendemic regions, including the majority of the United States, where travel-related exposure occurs in short and well-defined windows of gestation. Our low rate of infection and relatively rare evidence of congenital Zika syndrome parallels human population-based data.
NEUTRONS FROM SMALL TUBES. I. PHILLIPS TUBE: CONTINUOUS OR PULSED OPERATION (1960)

A sealed neutron-generator tube which uses the d-t reaction to produce 3 x 10/sup 18/ neutrons/sec during continuous operation was developed. When adapted for pulsed operation, it yielded a peak output of 3 x 10/sup 10/ neutrons/ sec. This tube contains a Penning ion source, a 100 to 200 kv accelerating system, a replenisher to keep the pressure within the tube constant, and a titanium-tritium target that is selfreplenishing. The Penning source supplies mainly molecular ions, but has as advantages long life, robustness, and simplicity. One tube was life-tested for 200 hr at an output of 2 x 10/sup 8/ neutrons/sec with no fall-off in performanes. This tube was also operated at ambient temperatures up to 120 deg C without any drop in yield. (M.C.G.)
Better Than Worst-Case Decoding for Quantum Error Correction (2023)

The overheads of classical decoding for quantum error correction in cryogenic quantum systems grow rapidly with the number of logical qubits and their correction code distance. Decoding at room temperature is bottlenecked by refrigerator I/O bandwidth while cryogenic on-chip decoding is limited by area/power/thermal budget.
Polycations as outer membrane-disorganizing agents (1983)

The outer membrane-disorganizing effect of a short (10-min) treatment with polycationic agents was studied with smooth Salmonella typhimurium used as a test organism. The polycationic agents were the protamine salmine, a lysine polymer with 20 lysine residues (lysine20), and the deacylated polymyxin B derivative polymyxin B nonapeptide. Two different types of outer membrane-disorganizing were found. Protamine and lysine20 released 20 to 30% of the lipopolysaccharide from the outer membrane and sensitized the bacteria to the anionic detergent sodium dodecyl sulfate but did not (under these conditions) make the bacteria permeable to the hydrophobic probes fusidic acid and actinomycin D. In contrast, polymyxin B nonapeptide did not release lipopolysaccharide or sensitize the bacteria to sodium dodecyl sulfate but made the outer membrane permeable to the hydrophobic probes. None of the agents was bactericidal under the conditions used or caused any leakage of periplasmic beta-lactamase. Polymyxin B was used as a reference and showed characteristic outer membrane-disorganizing action. In thin-section electron microscopy, polymyxin B nonapeptide caused the appearance of long, narrow, finger-like projections on the outer membrane. Protamine and lysine20 caused a distinctly wrinkled appearance of the outer membrane but no projections.
Macrolide Use Leads to Clinical and Radiological Improvement in Patients with Cryptogenic Organizing Pneumonia (2014)

Cryptogenic organizing pneumonia is an idiopathic form of organizing pneumonia (also known as bronchiolitis obliterans organizing pneumonia). Because cryptogenic organizing pneumonia is considered an inflammatory disease, it characteristically responds to the broad-spectrum antiinflammatory corticosteroids, although relapse is common on discontinued use. Additionally, long-term use of corticosteroids has many side effects. In severe cases in which corticosteroids have failed, either cytotoxic therapy or macrolide therapy is used. Because of the toxicity and adverse effects of cytotoxic therapy (e.g., cyclophosphamide), this therapy option cannot be used long term in refractory cases. Macrolide therapy has been shown to be an effective antiinflammatory agent that is relatively safe when used on a long-term basis in patients with cryptogenic organizing pneumonia.
Design and laboratory testing of a MEMS accelerometer array for subsidence monitoring (2018)

The <i>in situ</i> monitoring of displacement variation is important for studying the seabed subsidence mechanism. To meet the multi-point measurement requirements for vertical displacement in subsidence monitoring of the seabed surface, a Micro-Electro-Mechanical Systems accelerometer array was designed. By sensing the tilt angles, displacements on the array can be calculated. The subsidence is calculated as the difference in the displacements from the initial values. To improve the accuracy of the displacement calculation, a calibration model of the tilt angle was presented. The model parameters are computed through a least squares estimation method, which is solved by the Levenberg-Marquardt algorithm. Experimental results show that the calibration model performs excellently with the maximum error of tilt angle being less than 1° in the measurement range (-90°, 90°). The displacement measurement accuracy of the array (2.1 m long) is almost less than 1 cm. Thus, the results show a strong agreement between the detected data and actual deformation in the test.
Secure sessions for Web services (2007)

We address the problem of securing sequences of SOAP messages exchanged between web services and their clients. The WS-Security standard defines basic mechanisms to secure SOAP traffic, one message at a time. For typical web services, however, using WS-Security independently for each message is rather inefficient; moreover, it is often important to secure the integrity of a whole session, as well as each message. To these ends, recent specifications provide further SOAP-level mechanisms. WS-SecureConversation defines security contexts , which can be used to secure sessions between two parties. WS-Trust specifies how security contexts are issued and obtained. We develop a semantics for the main mechanisms of WS-Trust and WS-SecureConversation, expressed as a library for TulaFale, a formal scripting language for security protocols. We model typical protocols relying on these mechanisms and automatically prove their main security properties. We also informally discuss some pitfalls and limitations of these specifications.
Glass cutting by femtosecond pulsed irradiation (2004)

We report on quartz and glass cutting by a lateral scanning of femtosecond pulses (150 fs at 1 kHz repetition rate) of 800 nm wavelength at room and low pressure (5 Torr) air ambience. Pulses were focused by a low numerical aperture (NA0.1) objective lens. Optimization of fabrication conditions: pulse energy and scanning speed were carried out to achieve large-scale (millimeter-to-centimeter) cutting free of microcracks of submicron dimensions along the edges and walls of the cut. Cutting through out the samples of 0.1-0.5 mm thickness was successfully achieved without apparent heat affected zone. At low air pressure (5 Torr) ambience, redeposition of ablated material was considerably reduced. It is demonstrated that the damage on the rear surface was induced by the stress waves, which originated from the plasma ablation pressure pulse. The mechanism of femtosecond-laser cutting of transparent materials at high irradiance and the influence of stress waves generated by plasma plume are discussed.
Aptamer Displacement Identifies Alternative Small-Molecule Target Sites that Escape Viral Resistance (2007)

Aptamers targeting reverse transcriptase (RT) from HIV-1 inhibit viral replication in vitro, presumably by competing with binding of the primer/template complex. This site is not targeted by the currently available small-molecule anti-HIV-1 RT inhibitors. We have identified SY-3E4, a small-molecule inhibitor of HIV-1 RT, by applying a screening assay that utilizes a reporter-ribozyme regulated by the anti-HIV-1 RT aptamer. SY-3E4 displaces the aptamer from the protein, selectively inhibits DNA-dependent, but not RNA-dependent, polymerase activity, and inhibits the replication of both the wild-type virus and a multidrug-resistant strain. Analysis of available structural data of HIV-1 and HIV-2 RTs rationalizes many of the observed characteristics of the inhibitory profiles of SY-3E4 and the aptamer and suggests a previously not considered region in these RTs as a target for antiviral therapy. Our study reveals unexplored ways for rapidly identifying alternative small-molecule target sites in proteins and illustrates strategies for overcoming resistance-conferring mutations with small molecules.
Influence of Poly-(L-Lactic Acid) Nanofiber Functionalization on Maximum Load, Young's Modulus, and Strain of Nanofiber Scaffolds Before and After Cultivation of Osteoblasts: AnIn VitroStudy (2009)

The aim of this study was to characterize the influence of functionalization of synthetic poly-(L-lactic acid) (PLLA) nanofibers on mechanical properties such as maximum load, elongation, and Young's modulus. Furthermore, the impact of osteoblast growth on the various nanofiber scaffolds stability was determined. Nanofiber matrices composed of PLLA, PLLA-collagen, or BMP-2-incorporated PLLA were produced from different solvents by electrospinning. Standardized test samples of each nanofiber scaffold were subjected to failure protocol before or after incubation in the presence of osteoblasts over a period of 22 days under osteoinductive conditions. PLLA nanofibers electrospun from hexafluoroisopropanol (HFIP) showed a higher strain and tended to have increased maximum loads and Young s modulus compared to PLLA fibers spun from dichloromethane. In addition, they had a higher resistance during incubation in the presence of cells. Functionalization by incorporation of growth factors increased Young's modulus, independent of the solvent used. However, the incorporation of growth factors using the HFIP system resulted in a loss of strain. Similar results were observed when PLLA was blended with different ratios of collagen. Summarizing the results, this study indicates that different functionalization strategies influence the mechanical stability of PLLA nanofibers. Therefore, an optimization of nanofibers should not only account for the optimization of biological effects on cells, but also has to consider the stability of the scaffold.
Robust adaptive terminal sliding mode control for dynamic positioning of a semi-submersible offshore platform (2018)

In this paper, a robust adaptive terminal sliding mode controller is proposed for dynamic positioning of a semi-submersible offshore platform. First, a state feedback controller is designed to stabilize the nominal system. Then a robust adaptive terminal sliding mode compensator is developed to eliminate the effects of uncertain dynamics and disturbances. It is shown, using Lyapunov methods, that the tracking error is driven to zero in finite time using the proposed control. The efficacy of the control algorithm is validated using simulation studies; it is shown that recent developments in the domain of robust exact differentiation are very helpful for controller implementation.
[On physique of astronauts as viewed from the point of Traditional Chinese Medicine]. (2002)

Good health physique and fine psychological quality are required for an astronaut. Selection and health care of foreign astronauts are based on western medicine principles. In order to initiate space medicine with a new feature of Chinese Medicine. It needs further discussion on the application of Traditional Chinese Medicine to the research and practice of space medical science.
The fetal femur/foot length ratio: a new parameter to assess dysplastic limb reduction. (1988)

The relationship between growth of the fetal femur and foot length was examined between 14-40 weeks' gestation in 182 normal singleton pregnancies. A significant correlation was demonstrated (r = 0.98; P less than .0001). The femur/foot length ratio was found to be approximately 1 throughout this age range. The fifth and 95th percentile confidence intervals of the femur/foot length ratio versus gestational age were then defined. The femur/foot length ratio was also measured directly in 12 fetuses after second-trimester abortion; these measurements compared favorably with the ultrasound femur/foot length ratio nomogram. The discriminatory power of the femur/foot length ratio chart to differentiate fetuses with skeletal dysplasias from those with pseudo-limb reduction due to constitutional factors or intrauterine growth retardation (IUGR) was tested in 16 sequential cases with femur measurements below the fifth percentile. Two cases suspected of having symmetrical IUGR and five cases suspected of being constitutionally small were found to have femur/foot length ratios within the 90th percentile range. Limb reduction deformities were suspected in the nine remaining cases, and the femur/foot length ratios in these fetuses were all found to be less than the fifth percentile. The femur/foot length ratio nomogram appears to be a useful parameter to help differentiate fetuses that have dysplastic limb reduction from those whose limbs are short because of constitutional factors or IUGR.
Aggrephagy Deficiency in the Placenta: A New Pathogenesis of Preeclampsia (2021)

Aggrephagy is defined as the selective degradation of aggregated proteins by autophagosomes. Protein aggregation in organs and cells has been highlighted as a cause of multiple diseases, including neurodegenerative diseases, cardiac failure, and renal failure. Aggregates could pose a hazard for cell survival. Cells exhibit three main mechanisms against the accumulation of aggregates: protein refolding by upregulation of chaperones, reduction of protein overload by translational inhibition, and protein degradation by the ubiquitin-proteasome and autophagy-lysosome systems. Deletion of autophagy-related genes reportedly contributes to intracellular protein aggregation in vivo. Some proteins recognized in aggregates in preeclamptic placentas include those involved in neurodegenerative diseases. As aggregates are derived both intracellularly and extracellularly, special endocytosis for extracellular aggregates also employs the autophagy machinery. In this review, we discuss how the deficiency of aggrephagy and/or macroautophagy leads to poor placentation, resulting in preeclampsia or fetal growth restriction.
DSP Processor Fundamentals: Architectures and Features (1997)

This cutting-edge, practical guide brings you an independent, comprehensive introduction to DSP processor technology. A thorough tutorial and overview of DSP architectures, this book incorporates a broad range of today's product offerings in examples that illustrate DSP features and capabilities. This book is especially useful to electronic systems designers, processor architects, engineering managers, and product planners
Primary Abdominal Wall Actinomycosis (2012)

Actinomycosis of the anterior abdominal wall is rare. We report a 50-year-old man who presented with a right lower lateral chest wall mass of six years duration Computed tomography showed a 8 cm mass projecting from right lower lateral chest wall associated with extension of the right abdominal wall. En bloc resection including muscles, 9th and 10th ribs and a partial portion of diphragm was made. And direct closure of abdominal wall defect was done. Histopathological examination of the mass was consistent with those of actinomycosis. The patient recovered completely without post-operative complications. The patient is receiving minocycline for three months now. doi:10.4021/jmc336w
Serum neurofilament light chain in pediatric MS and other acquired demyelinating syndromes (2019)

The significant correlation between CSF and serum NfL strengthens its reliability as a peripheral marker of neuroaxonal damage. Higher sNfL levels at baseline were associated with higher probability of future CDMS diagnosis in ADS-.
Performance of Neutron/Proton Source Based on Ion-Source-Assisted Radially Convergent Beam Fusion (2005)

Summary form only given. Radially convergent beam fusion (RCBF) has been studied for practical use as a portable neutron/proton source for various applications such as landmine detection and medical positron emission tomography. However, some problems remain for the practical use, and the most critical one is the insufficiency of absolute neutron/proton yields. In this study, a new RCBF device was designed and tested to obtain high neutron/proton yields. The key features of the new device are the cylindrical electrode configuration in consideration of better electrostatic confinement of ions and extraction of protons, and an integrated bucket-type ion source which consists of sixteen ferrite magnets and sixteen filaments. To investigate the performance characteristics of the device and the effect of the ion source, three types of experimental setup were used for comparison. At first, the basic RCBF setup was operated. Then a cusp magnetic field was applied by using ferrite magnets, and a thermionic cathode was added. As a result, it was confirmed that the ion source works effectively. At the same discharge condition of voltage and current, the obtained neutron production rate was about one order of magnitude higher than that of the conventional spherical RCBF device. The maximum neutron production rate of 6.8times10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">9</sup> n/s was obtained at a pulsed discharge of -70 kV, 10 A
Inherent characteristics of metachronous metastatic renal cell carcinoma in the era of targeted agents (2017)

Initial tumor size or T stage did not affect TTF or OS. Patients who could not undergo metastasectomy and rapidly developed multiple metastases with higher corrected calcium and initial tumors with sarcomatoid features were less likely to benefit from targeted therapy; thus, the new agents under development or clinical trials could be more helpful than the use of standard targeted agents.