gebhart/patrepeval huggingface dataset:
A high dynamic range multi-standard CMOS mixer for GSM, UMTS and IEEE802.11b-g-a applications (2008)

Software defined radios are a topic of intense research and constitute one key industry need for future generation wireless products. In this paper, we investigate the down-conversion mixer, a particularly challenging block, due to the stringent dynamic range requirements set by cellphone applications and the wide operation bandwidth. The proposed mixer is based on a Gilbert cell and operates between 900 MHz and 6 GHz. The parasitic capacitor of the switching pair, main responsible for the limited dynamic range, is tuned out by means of a spiral inductor at 900 MHz, a transformer based programmable inductor between 1.7 GHz and 2.4 GHz, and a small spiral in the 5 GHz-6 GHz range. Prototypes have been integrated in a 65 nm CMOS technology and are operated from a 1.2 V supply. Minimum IIP2 and maximum average noise are 65 dBm and 5.4 nV/sqrt (Hz) in DCS. The mixer current consumption is 7.5 mA.
Review: A Musica Brasileira e seus fundamentos (Brief History of Music in Brazil) by Luiz Heitor Corrêa de Azevedo (1950)

Book Review| April 01 1950 Review: A Musica Brasileira e seus fundamentos (Brief History of Music in Brazil) by Luiz Heitor Corrêa de Azevedo A Musica Brasileira e seus fundamentos (Brief History of Music in Brazil) Luiz Heitor Corrêa de Azevedo Carleton Sprague Smith Carleton Sprague Smith Search for other works by this author on: This Site PubMed Google Scholar Journal of the American Musicological Society (1950) 3 (1): 56–57. https://doi.org/10.2307/829855 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Carleton Sprague Smith; Review: A Musica Brasileira e seus fundamentos (Brief History of Music in Brazil) by Luiz Heitor Corrêa de Azevedo. Journal of the American Musicological Society 1 April 1950; 3 (1): 56–57. doi: https://doi.org/10.2307/829855 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search nav search search input Search input auto suggest search filter All ContentJournal of the American Musicological Society Search This content is only available via PDF. Copyright 1950 The American Musicological Society Article PDF first page preview Close Modal You do not currently have access to this content.
Stability of Ni/SiO2-ZrO2 catalysts towards steaming and coking in the dry reforming of methane with carbon dioxide (2016)

吸着，温度规划了氧化，温度规划减小，并且在在 850 点的与二氧化碳的甲烷的干燥改过为他们的活动和稳定性测试了???挠瑡污獹獴栠摡椠灭潲敶?佃猼'T资???洠瑥慨慮楴湯愠瑣癩瑩?獥数楣污祬愠?潬?整灭牥瑡牵獥??‰潴??㈠?杭漠?????猯'T?ㄠ??杭漠?????猯'T￣湡??洿?景?猼'T????眠楨档爠獥汵整
Challenges in Translating GWAS Results to Clinical Care (2016)

Clinical genetic testing for Mendelian disorders is standard of care in many cases; however, it is less clear to what extent and in which situations clinical genetic testing may improve preventive efforts, diagnosis and/or prognosis of complex disease. One challenge is that much of the reported research relies on tag single nucleotide polymorphisms (SNPs) to act as proxies for assumed underlying functional variants that are not yet known. Here we use coronary artery disease and melanoma as case studies to evaluate how well reported genetic risk variants tag surrounding variants across population samples in the 1000 Genomes Project Phase 3 data. We performed a simulation study where we randomly assigned a "functional" variant and evaluated how often this simulated functional variant was correctly tagged in diverse population samples. Our results indicate a relatively large error rate when generalizing increased genetic risk of complex disease across diverse population samples, even when generalizing within geographic regions. Our results further highlight the importance of including diverse populations in genome-wide association studies. Future work focused on identifying functional variants will eliminate the need for tag SNPs; however, until functional variants are known, caution should be used in the interpretation of genetic risk for complex disease using tag SNPs.
LDPC Codes on Partial Geometries: Construction, Trapping Set Structure, and Puncturing (2013)

Many known constructions of LDPC codes can be placed in a general framework using the notion of partial geometries. Based on this notion, the structure of such LDPC codes can be analyzed using a geometric approach that illuminates important properties of their parity-check matrices. In this approach, trapping sets are represented by subgeometries of the geometry used to construct the code. Based on the incidence relations between lines and points in this geometry, the structure of trapping sets is investigated. On the other hand, it is shown that removing a subgeometry corresponding to a trapping set gives a punctured matrix which can be used as a parity-check matrix of an LDPC code. This relates trapping sets, represented by subgeometries, and punctured matrices, represented by the residual geometries. The null spaces of these punctured matrices are LDPC codes which inherit many of the good structural properties of the original code. Hence, new LDPC codes, with various lengths and rates, can be obtained by puncturing an LDPC code constructed based on a partial geometry. Furthermore, these punctured matrices and codes can be used in a two-phase decoding scheme to correct combinations of errors and erasures.
Structure−Reactivity Studies of Serum Paraoxonase PON1 Suggest that Its Native Activity Is Lactonase (2005)

PON1 is the best-studied member of a family of enzymes called serum paraoxonases, or PONs, identified in mammals (including humans) and other vertebrates as well as in invertebrates. PONs exhibit a range of important activities, including drug metabolism and detoxification of organophosphates such as nerve agents. PON1 resides on HDL (the "good cholesterol") and is also involved in the prevention of atherosclerosis. Despite this wealth of activities, the identity of PON1's native substrate, namely, the substrate for which this enzyme and other enzymes from the PON family evolved, remains unknown. To elucidate the substrate preference and other details of PON1 mechanism of catalysis, structure-activity studies were performed with three groups of substrates that are known to be hydrolyzed by PON1: phosphotriesters, esters, and lactones. We found that the hydrolysis of aryl esters is governed primarily by steric factors and not the pK(a) of the leaving group. The rates of hydrolysis of aliphatic esters are much slower and show a similar dependence on the pK(a) of the leaving group to that of the nonenzymatic reactions in solution, while the aryl phosphotriesters show much higher dependence than the respective nonenzymatic reaction. PON1-catalyzed lactone hydrolysis shows almost no dependence on the pK(a) of the leaving group, and unlike all other substrates, lactones seem to differ in their K(M) rather than k(cat) values. These, and the relatively high rates measured with several lactone substrates (k(cat)/K(M) approximately 10(6) M(-)(1) s(-)(1)) imply that PON1 is in fact a lactonase.
Study on the Optimal Access Orbiter Selection Algorithm in Mars Automatic Relay Communications (2019)

In current Mars relay communications, the Consultative Committee for Space Data Systems (CCSDS) Proximity-1 protocol is simple and efficient but it exhibits low flexibility in optimal access orbiter selection. Once connected with the first successful hailing orbiter, the rover would not switch to other better orbiters until the end of that connection, which makes it difficult to provide more convenient and efficient data relay services. The entire system cost is essential for optimal access orbiter selection, which includes both the Proximity-1 links' transmission cost concerned with the data transmission energy consumption and the orbiters' storage cost concerned with the data buffering energy consumption, thus minimizing the system cost on unit data volume could reduce energy consumption and extend the deep space vehicle's life. We employ long-term simulations of the single rover, simultaneously tracking two orbiters utilizing the improved Hotelling oligopoly model, and reveal the potential improvements for the current “first-come first-serve” selection strategy. In this article, a complete solution is proposed to solve the optimal access orbiter selection issues, including the geometric model, orbit design, oligopoly model, storage cost, and optimal selection algorithms. Simulation results show that our new algorithm outperforms current CCSDS Proximity-1 protocols and distance-dependent selection algorithm in the system cost on unit data volume with the selection gains $36.14\%$ and $ 29.59\%$, respectively, which could be used as the rover's optimal access orbiter selection algorithm in Mars automatic relay communications.
Substrate-specific Interactions with the Heme-bound Oxygen Molecule of Nitric-oxide Synthase (2007)

We report the characterization by resonance Raman spectroscopy of the oxygenated complex (Fe(II)O(2)) of nitric-oxide synthases of Staphylococcus aureus (saNOS) and Bacillus subtilis (bsNOS) saturated with N(omega)-hydroxy-l-arginine. The frequencies of the nu(Fe-O) and nu(O-O) modes were 530 and 1135 cm(-), respectively, in both the presence and absence of tetrahydrobiopterin. On the basis of a comparison of these frequencies with those of saNOS and bsNOS saturated with l-arginine (nu(Fe-O) at 517 cm(-1) and nu(O-O) at 1123 cm(-1)) and those of substrate-free saNOS (nu(Fe-O) at 517 and nu(O-O) at 1135 cm(-1)) (Chartier, F. J. M., Blais, S. P., and Couture, M. (2006) J. Biol. Chem. 281, 9953-9962), we propose two models that account for the frequency shift of nu(Fe-O) (but not nu(O-O)) upon N(omega)-hydroxy-l-arginine binding as well as the frequency shift of nu(O-O) (but not nu(Fe-O)) upon l-arginine binding. The implications of these substrate-specific interactions with respect to catalysis by NOSs are discussed.
Energy Pumping in Nonlinear Mechanical Oscillators: Part II—Resonance Capture (2000)

We study energy pumping in an impulsively excited, two-degrees-of-freedom damped system with essential (nonlinearizable) nonlinearities by means of two analytical techniques. First, we transform the equations of motion using the action-angle variables of the underlying Hamiltonian system and bring them into the form where two-frequency averaging can be applied. We then show that energy pumping is due to resonance capture in the 1:1 resonance manifold of the system, and perform a perturbation analysis in an Oε neighborhood of this manifold in order to study the attracting region responsible for the resonance capture. The second method is based on the assumption of 1:1 internal resonance in the fast dynamics of the system, and utilizes complexification and averaging to develop analytical approximations to the nonlinear transient responses of the system in the energy pumping regime. The results compare favorably to numerical simulations. The practical implications of the energy pumping phenomenon are discussed.
Discriminative clustering for content-based tag recommendation in social bookmarking systems (2009)

Abstract. We describe and evaluate a discriminative clustering approach for content-based tag recommendation in social bookmarking systems. Our approach uses a novel and efficient discriminative clustering method that groups posts based on the textual contents of the posts. The method also generates a ranked list of discriminating terms for each cluster. We apply the clustering method to build two clustering models – one based on the tags assigned to posts and the other based on the content terms of posts. Given a new posting, a ranked list of tags and content terms is determined from the clustering models. The final tag recommendation is based on these ranked lists. If the poster’s tagging history is available then this is also utilized in the final tag recommendation. The approach is evaluated on data from BibSonomy, a social bookmarking system. Prediction results show that the tag-based clustering model is more accurate than the term-based clustering model. Combining the predictions from both models is better than either model’s predictions. Significant improvement in recommendation is obtained over the baseline method of recommending the most frequent tags for all posts. 1
ChemInform Abstract: Aliphatic Carboxylic Acids via Aldehyde Oxidation (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A Novel Approach to Implement Takagi-Sugeno Fuzzy Models (2015)

This paper proposes a modified algorithm in Takagi-Sugeno (T-S) fuzzy modelling for a complex nonlinear system. First, the Gaussian kernel based fuzzy c-mean clustering method is presented to find a scalar offset of the linear function. Secondly, the fuzzy c-regression model (FCRM) and the weighted recursive least square (WRLS) algorithm are adopted to calculate the parameters of the linear model according to individual input variables. Finally, the proposed algorithm stops if the objective function is minimized, otherwise, returns to the first step. Two simulation examples are provided to demonstrate the effectiveness of the proposed T-S fuzzy modelling approach.
Distribution of serum gastrin in different forms of gastritis among Estonian population. (1991)

Gastrin level was measured in frozen serum samples of 215 adult Estonians, who took part in a representative population study in 1979, and were followed-up in 1985. Gastric morphology was verified by multiple biopsy specimens from the fundal and antral parts of the stomach, obtained at direct-vision gastroscopy. Certain combinations of antral-body mucosa were revealed which have, and which do not have a significant influence on the fasting gastrin levels. Low values might be observed in subjects having severe atrophic gastritis simultaneously in fundal as well as in antral area. However, in others low concentration of gastrin was seen without any (or without severe) changes of the mucosa. Therefore different factors as duodenal gastrin-producing cells, several molecular forms of gastrin, age of the person seems to contribute to the total serum gastrin level besides the gastric mucosa. High values of gastrin are characteristic to normal antral mucosa accompanied by moderate or severe fundal gastritis.
Delivery of affordable and scalable encapsulated allogenic/autologous mesenchymal stem cells in coagulated platelet poor plasma for dental pulp regeneration (2022)

The main goal of regenerative endodontics procedures (REPs) is to revitalize teeth by the regeneration of healthy dental pulp. In this study, we evaluated the potential of combining a natural and accessible biomaterial based on Platelet Poor Plasma (PPP) as a support for dental pulp stem cells (DPSC) and umbilical cord mesenchymal stem cells (UC-MSC). A comparison study between the two cell sources revealed compatibility with the PPP based scaffold with differences noted in the proliferation and angiogenic properties in vitro. Additionally, the release of growth factors including VEGF, HGF and DMP-1, was detected in the media of cultured PPP and was enhanced by the presence of the encapsulated MSCs. Dentin-Discs from human molars were filled with PPP alone or with MSCs and implanted subcutaneously for 4 weeks in mice. Histological analysis of the MSC-PPP implants revealed a newly formed dentin-like structure evidenced by the expression of Dentin sialophosphoprotein (DSPP). Finally, DPSC induced more vessel formation around the dental discs. This study provides evidence of a cost-effective, xenofree scaffold that is compatible with either autologous or allogenic strategy for dental pulp regeneration. This attempt if successfully implemented, could make REPs treatment widely accessible, contributing in improving global health conditions.
Interleukin 2 Gene Therapy for Prostate Cancer: Phase I Clinical Trial and Basic Biology (2001)

Twenty-four patients with locally advanced prostate cancer (CaP) were enrolled in a phase I clinical trial using gene-based immunotherapy. A functional DNA-lipid complex encoding the interleukin 2 (IL-2) gene (Leuvectin; Vical, San Diego, CA) was administered intraprostatically into the hypoecogenic tumor lesion, using transrectal ultrasound guidance. Two groups of patients having locally advanced tumors were enrolled to receive a treatment regimen composed of two serial intraprostatic injections of the IL-2 gene agent administered 1 week apart. The first groups of patients included radical prostatectomy candidates who subsequently underwent surgery after the completion of the treatment regimen. The second group consisted of patients who had failed a prior therapy. Prostate specimens of the treated areas were attained after treatment and compared with the transrectal biopsies performed at baseline to assess for any responses. IL-2 gene therapy was well tolerated, with no grade 3 or 4 toxic reactions occurring. The most commonly reported symptoms were mild hematuria, transient rectal bleeding, and perineal discomfort that are likely attributable to the injection itself. During the entire course of treatment, there were no significant changes in American Urologic Association (AUA) symptom scores, in hematologic disturbances, electrolyte imbalances, or hepatic functions. Evidence of systemic immune activation was observed after IL-2 gene therapy, based on an increase in the intensity of T cell infiltration seen on immunohistochemical analysis of tissue samples from the injected tumor sites, and based on increased proliferation rates of peripheral blood lymphocytes that were cocultured with patient serum collected after treatment. Furthermore, transient decreases in serum prostate-specific antigen (PSA) (responders) were seen in 16 of 24 patients (67%) on day 1. Fourteen of the patients persisted in this decrease to day 8 (58%). In eight patients the PSA level rose (nonresponders). More patients (9 to 10) in the group that failed prior therapy responded to the IL-2 gene injections (chi-square test, p = 0.04), and 6 of the 9 also had lower than baseline PSA levels at week 10 after treatment. To the best of our knowledge, this is the first clinical study of its kind aimed at exploring the role of IL-2-based gene therapy in CaP patients. This phase I trial demonstrated the safety of intraprostatic Leuvectin injection, with transient PSA-based responses seen after therapy.
BORDETELLA PERTUSSIS: CARACTERIZACIÓN EPIDEMIOLÓGICA Y DIAGNÓSTICO (2005)

"Introducción: La tos ferina es una enfermedad transmisible e inmunoprevenible que actualmente esta resurgiendo en países del primer mundo. Objetivo: La investigación tuvo como propósito determinar la circulación de Bordetella pertussis en pacientes menores de 1año, en el servicio de pediatría del Hospital Universitario de Caracas entre junio 2001- noviembre 2002. Métodos: Se incluyeron pacientes menores de 1 año con síntomas sospechosos de tos ferina según la Organización Mundial de la Salud (OMS). Se realizó encuesta epidemiológica y clínica, cultivo de secreción nasofaríngea y serología para Ig M. Resultados: Durante 17 meses se identificaron 66 casos sospechosos de tos ferina, 35 fueron incluidos. Hubo confirmación bacteriológica en 8.6%, la negatividad del cultivo se correlacionó 100% con serología. Los confirmados tenían menos de 3 meses de edad, con antecedentes de contacto, ausencia de inmunización y clínica de tos paroxística, cianosis y vómito post-tusígeno. Conclusión: Se confirma la circulación de Bordetella pertussis y se establecen bases para el inicio del modelo del proyecto de vigilancia epidemiológica."
Screening of plant-derived antifungal substances useful for the control of seedborne pathogens (2013)

The effect of plant essential oils, Solanum chilense and Aster sedifolius raw saponins, plant-derived colourants and Brassica carinata glucosinolate-containing tissues, for the control of seedborne fungi Alternaria dauci, Alternaria radicina, Colletotrichum lindemuthianum and Ascochyta rabiei, was evaluated. In vitro assays indicated that oregano essential oil, bark chestnut-derived colourant and B. carinata meals, showed a large spectrum of activity against all pathogens. S. chilense raw saponins were effective against A. dauci and A. radicina, while those from A. sedifolius also inhibited significantly C. lindemuthianum. Screening showed the antifungal potential of natural compounds.
Investigation of space launch vehicle catastrophic failures (1996)

Covers advancements in spacecraft and tactical and strategic missile systems, including subsystem design and application, mission design and analysis, materials and structures, developments in space sciences, space processing and manufacturing, space operations, and applications of space technologies to other fields.
Molecular genetics of serine and threonine catabolism in Saccharomyces cerevisiae. (1988)

The catabolic L-serine (L-threonine) deaminase of Saccharomyces cerevisiae allows the yeast to grow on media with L-serine or L-threonine as sole nitrogen source. A mutant, cha1 (catabolism of hydroxyamino acids), lacking this enzyme activity has been isolated. We have cloned the CHA1 gene by complementation of a cha1 mutation. Northern analysis showed that CHA1 mRNA has a size of about 1200 ribonucleotides. CHA1 is probably the structural gene for the enzyme; it is an abundant RNA in cells grown with serine and threonine as nitrogen source, whereas it is not detected when cells are grown on ammonium or proline, i.e., the transcription of the CHA1 gene is induced by serine or threonine. Under induced growth conditions haploid ilv1 CHA1 strains do not require isoleucine, i.e., the catabolic deaminase is able to substitute for the biosynthetic threnonine deaminase encoded by the ILV1 gene. We have identified a nuclear, recessive mutation, sil1, that suppresses ilv1 mutations by increased transcription of the CHA1 gene under growth conditions leading to partial induction. The sil1 mutation could exert its effect by increasing the effective pools of the hydroxyamino acids. Alternatively SIL1 may encode a negatively acting regulatory protein for CHA1.
Searching for Realizations of Finite Metric Spaces in Tight Spans (2016)

An important problem that commonly arises in areas such as internet traffic-flow analysis, phylogenetics and electrical circuit design, is to find a representation of any given metric $D$ on a finite set by an edge-weighted graph, such that the total edge length of the graph is minimum over all such graphs. Such a graph is called an optimal realization and finding such realizations is known to be NP-hard. Recently Varone presented a heuristic greedy algorithm for computing optimal realizations. Here we present an alternative heuristic that exploits the relationship between realizations of the metric $D$ and its so-called tight span $T_D$. The tight span $T_D$ is a canonical polytopal complex that can be associated to $D$, and our approach explores parts of $T_D$ for realizations in a way that is similar to the classical simplex algorithm. We also provide computational results illustrating the performance of our approach for different types of metrics, including $l_1$-distances and two-decomposable metrics for which it is provably possible to find optimal realizations in their tight spans.