gebhart/patrepeval huggingface dataset:
1185: Muscle Derived Cell Injection Technique to Optimze the Treatment of Stress Urinary Incontinence (2006)

You have accessJournal of UrologyModerated Poster, Tuesday, May 23, 2006, 10:00 am - 12:00 pm1 Apr 20061185: Muscle Derived Cell Injection Technique to Optimze the Treatment of Stress Urinary Incontinence Lesley K. Carr, Deborah Steele, Shannon Steele, David Wagner, Ryan Pruchnic, Ronald J. Jankowski, Janet Erickson, Fernando De Miguel, Naoki Yoshimura, Johnny Huard, and Michael B. Chancellor Lesley K. CarrLesley K. Carr More articles by this author , Deborah SteeleDeborah Steele More articles by this author , Shannon SteeleShannon Steele More articles by this author , David WagnerDavid Wagner More articles by this author , Ryan PruchnicRyan Pruchnic More articles by this author , Ronald J. JankowskiRonald J. Jankowski More articles by this author , Janet EricksonJanet Erickson More articles by this author , Fernando De MiguelFernando De Miguel More articles by this author , Naoki YoshimuraNaoki Yoshimura More articles by this author , Johnny HuardJohnny Huard More articles by this author , and Michael B. ChancellorMichael B. Chancellor More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)33410-4AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "1185: Muscle Derived Cell Injection Technique to Optimze the Treatment of Stress Urinary Incontinence." The Journal of Urology, 175(4S), p. 381 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 175Issue 4SApril 2006Page: 381 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Lesley K. Carr More articles by this author Deborah Steele More articles by this author Shannon Steele More articles by this author David Wagner More articles by this author Ryan Pruchnic More articles by this author Ronald J. Jankowski More articles by this author Janet Erickson More articles by this author Fernando De Miguel More articles by this author Naoki Yoshimura More articles by this author Johnny Huard More articles by this author Michael B. Chancellor More articles by this author Expand All Advertisement PDF downloadLoading ...
Clinical correlates of basal hepatic glucose output and metabolic clearance rate of glucose using glucose-C-peptide-body mass indexes in ambulatory type 2 diabetic patients. (1987)

The use of glucose (G)--C-peptide (C)--body mass indexes (BMI) as clinical determinants of likely response to oral sulphonylurea agents in type 2 diabetic patients have been suggested by some investigators. The relationships between these clinical parameters are usually expressed as scores (C/G, G/BMI and C/BMI scores). Based on this approach, we have determined the significance of these clinical scores using isotopically-derived basal glucose fluxes (D[3-3H]glucose technique) in 26 subjects (10 type 2 diabetics and 16 nondiabetics) with a broad range (72-346 mg/dl) of fasting serum glucose (FSG) and BMI (19-39 kg/m2). The basal hepatic glucose output (HGO) correlated positively with FSG, BMI and G/BMI score and negatively with C/G score in the diabetic patients. We found no significant relationships between basal HGO and most of these parameters except FSG and G/BMI in the normal subjects. The basal metabolic clearance rate of glucose (MCR) significantly correlated, but inversely, with FSG and G/BMI score, but not with the C/G score or BMI in the diabetic patients. In the normal subjects, MCR significantly, but negatively, correlated with the BMI, but not with FSG, C/G or G/BMI scores. Neither basal HGO nor MCR correlated with fasting serum C-peptide, duration of diabetes or daily insulin dose. As a group, the basal HGO correlated positively with FSG, BMI and G/BMI scores but negatively with C/G Score. However, the basal MCR correlated negatively with FSG, BMI and G/BMI scores but positively with C/G score. In summary, the present cross-sectional study provides additional information on the determinants of fasting serum glucose levels in type 2 diabetic patients.(ABSTRACT TRUNCATED AT 250 WORDS)
Investigation of Desiccants and CO2 Sorbents for Advanced Exploration Systems (2016)

Advanced Environmental Control and Life Support System (ECLSS) design is critical for manned space flight beyond Earth. Current systems enable extended missions in low-Earth orbit, but for deep-space missions, not only will astronauts be outside the reach of resupply operations from Earth but they will also need to handle malfunctions and compensate for the degradation of materials. These two daunting challenges must be overcome for long-term independent space flight. In order to solve the first, separation and recycling of onboard atmosphere is required. Current systems utilize space vacuum to fully regenerate CO2 sorbent beds, but this is not sustainable. The second challenge stems from material and performance degradation due to operational cycling and on-board contaminants. This report will review the recent work by the ECLSS team at Marshall Space Flight Center towards overcoming these challenges by characterizing materials via novel methods and by assessing new air revitalization systems.
Can Clinical Trials Requiring Frequent Participant Contact Be Conducted Over the Internet? Results From an Online Randomized Controlled Trial Evaluating a Topical Ointment for Herpes Labialis (2004)

We efficiently recruited participants and achieved high overall retention rates. However, participant adherence to the daily outbreak visit schedules was low and only 7 (50%) participants used the cream as directed. These limitations could be addressed in future Internet-based studies by using Personal Digital Assistants (PDAs), using reminder devices, and providing incentives. By enhancing participant adherence, clinical trials requiring frequent participant contact may be feasible over the Internet.
Pathogenesis of Autoantibody Production and Glomerulonephritis in Pristane-Treated Mice (1999)

Systemic lupus erythematosus (SLE) is a systemic autoimmune disease of uncertain etiology that is influenced by both genetic and environmental factors. Although lupus is usually considered to be primarily a genetic disorder, environmental triggers, such as ultraviolet light and certain medications (1), can trigger the disease in genetically susceptible hosts. The isoprenoid alkane pristane (2,6,10,14-tetramethypentadecane), a component of mineral oil, has recently been shown to be a powerful environmental trigger that induces a lupus-like syndrome in nonautoimmune strains of mice (2,3). Pristane-treated mice develop autoantibodies associated with SLE, including the marker antibodies anti-Sm, double-stranded DNA (dsDNA), and ribosomal P, as well as less disease-specific autoantibodies (anti-nRNP, Su, single-stranded DNA [ssDANA], and histone) at titers as high as 1:250,000 (4). They also develop immune complex—mediated glomerulonephritis closely resembling human lupus nephritis with glomerular IgG, IgM and complement deposition, and mesangial hypercellularity (2,3). These similarities with human lupus and the fact that disease can be induced in virtually all normal strains of mice, regardless of genetic background, suggest that this new inducible lupus model may be useful for defining the immunologic defects causing SLE.
Use of a nanoscale Kelvin probe for detecting wear precursors (1998)

A version of a Kelvin probe that has been developed for an atomic force microscope (AFM), here referred to as a nano-Kelvin probe, is used to create maps of surface potential for study of samples that have been abraded by an AFM tip. The focus is on the wear at very low loads that involve the absence of wear debris and/or wear scars. Wear scars at higher loads, where significant damage to surface has occurred, have also been studied for reference purposes. Samples studied include single crystal aluminum, alumina, gold, and silicon. It is shown that even in cases where there is little or no damage to the surface, as observed by topography scans of an AFM, there is often a large change in the potential at the surface of the sample. The change in surface potential is believed to be the result of chemical and structural changes in the first few nanometers of the sample. We have shown that, even in the case of “zero wear” (that is, no visible deformation of the surface), there can be a significant change in the surface potential inside the wear scar. This allows for the study of the onset of wear in the ultralow wear regime that is not possible with other techniques. The study of wear precursors is particularly important for the hard disk drive industry, the microelectromechanical systems industry, and other industries where the presence of any microscopic wear or debris can represent total failure.
Atomic-Layer Deposition on Noble Metal Powders. (2014)

Abstract not provided.
Retinoblastoma (1991)

Retinoblastoma, although a rare childhood cancer, is the most common primary malignant intraocular tumor of infancy and early childhood. In 75% of the cases, retinoblastoma is unilateral, and in 25% of the cases, retinoblastoma is bilateral. Presenting signs and symptoms of retinoblastoma, genetics, diagnostic tests, and their implications are reviewed in this paper. Treatment options for retinoblastoma (enucleation, external beam radiation, radioactive plaque, cryotherapy, photocoagulation, and chemotherapy) and their nursing care are discussed. Finally, second tumors such as osteosarcomas are discussed.
Session VIII: Summary: What is the Future of Contact Lenses in the New Millennium? (2003)

Sweeney, Deborah F. B.Optom., Ph.D.; Bergenske, Peter D. O.D.; Wilson, Graeme Ph.D.; Holden, Brien A. B.App.Sc., Ph.D., D.Sc.; Cavanagh, H. Dwight M.D., Ph.D.; Barr, Joseph T. O.D.Editor(s): Fonn, Desmond M.Optom.
Left ventricular unloading with intra‐aortic counter pulsation prior to reperfusion reduces myocardial release of endothelin‐1 and decreases infarction size in a porcine ischemia‐reperfusion model (2008)

LV unloading with an IABP prior to reperfusion reduces the extent of myocardial necrosis in hearts subjected to 1 hr of left anterior descending artery occlusion and 4 hr of reperfusion compared with either reperfusion alone or LV unloading after reperfusion. Inhibition of myocardial ET-1 release by LV unloading may be a significant mechanism of myocardial protection. These data suggest that in high-risk STEMI patients, IABP unloading prior to reperfusion might be more beneficial than IABP placement postreperfusion.
A Noise Prediction and Time-Domain Subtraction Approach to Deep Neural Network Based Speech Enhancement (2017)

Deep neural networks (DNNs) have recently been successfully applied to the speech enhancement task; however, the low signal-to-noise ratio (SNR) performance of DNN-based speech enhancement systems remains less than desirable. In this paper, we study an approach to DNN-based speech enhancement based on noise prediction. Three speech enhancement models based on noise prediction are proposed, and their performance is compared to that of conventional spectral-mapping models in seen and unseen noise tests. Objective test results show that the proposed noise prediction models perform well in enhancing speech quality in seen noise conditions and in enhancing high SNR speech signals. They also perform well in enhancing speech intelligibility in both seen and unseen noise conditions, but do not outperform the conventional models on quality metrics in unseen noise conditions. Further analysis of the enhanced speech signals is undertaken to explain the observed results.
Half-bridge driver with charge pump based high-side voltage regulator (2016)

This paper presents a half-bridge driver to fulfill the requirement for interfacing with MEMs sensors. The upper switch of the driver is implemented by a p-type power transistor to make the driver feasible for pulse density modulated input signal. The high-side “ground” reference voltage V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">SSH</sub> is regulated through the proposed charge pump circuit, which harvests the charges flowing into the V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">SSH</sub> node and boosts them to the supply of the power stage V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">HV</sub> . The charge pump is designed with reversion loss prevention function to achieve a voltage difference close to V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DD</sub> between V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">HV</sub> and V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">SSH</sub> . The driver is fabricated using the 0.18-μm CMOS process with 24-V LDMOS devices. The measurement results confirm the validation of the half-bridge driver with power efficiency up to 95%.
Real-time adaptive discrimination threshold estimation for embedded neural signals detection (2009)

Multi-electrode array systems used in neurological applications produce large amount of data because of the simultaneous continuous high-rate sampling on a large number of channels. This data flow must be reduced to envision compact data acquisition systems with wireless transmission for body implantation. In spike-related applications, the useful data is sparse due to the relative low neurons firing rate combined to the high sampling rate. High compression ratio can be achieved by detecting, extracting and storing only the relevant spike occurrences. The first step is to provide a simple yet robust discrimination threshold based on the characteristics of the noise distribution. This article presents both a method and its hardware implementation for adaptive spike detection.
Enhancement of the thermal and mechanical properties of a surface-modified boron nitride-polyurethane composite (2014)

Thermoplastic polyurethane (PU) elastomer, prepared from poly(tetramethylene glycol) and methyl diphenyl diisocyanate, was blended with boron nitride (BN) to fabricate a thermally conductive interface material. BN treated by a silane coupling agent (BN―NH2) and PU-grafted BN were prepared to fabricate a composite that has better thermal conductivity and mechanical strength. The surface-modified filler showed enhanced dispersibility and affinity because of the surface treatment with functional groups that affected the surface free energy, along with the structural similarity of the doped crystallized diisocyanate molecule with the matrix. The thermal conductivity increased from 0.349 to 0.467 W mk−1 on 20 wt% PU-grafted BN loading that is a 1.34-fold higher value than in the case of pristine BN loading at the same weight fraction. Moreover, the number of BN particles acting as defects, thereby reducing the mechanical strength, is decreased because of strong adhesion. We can conclude that these composite materials may be promising materials for a significant performance improvement in terms of both the thermal and mechanical properties of PU-based polymers. Copyright © 2014 John Wiley & Sons, Ltd.
II. An extract of a letter from Dr. William Oliver, communicated by Walter Moyle, Esq; (1693)

Abstract Sir, When we Cruised in the Bay of Biscay, June the 8th, and had a hundred Fathom of Water, we took a Quart Glass Bottle stopt with a large Cork, and after tyed down with a Strong Packthread, as we use to for Bottle Syder, or Ale fastening our Bottle to our Plumbing rope and with as soon as we perceiv'd, we drew it up again, and Found the Cork quite prefs'd thro' the neck of the Bottle into its cavity and the Bottle full of Salt Sea Water.
Intracellular Sphingosine‐1‐Phosphate is Involved in Lung Cancer Cells Proliferation (2022)

Background Sphingosine‐1‐phosphate (S1P) is a membrane‐derived bioactive phospholipid exerting a multitude of effects on respiratory cell physiology and pathology through five S1P receptors (S1PR1‐5). Higher levels of S1P have been registered in a broad range of respiratory diseases, including inflammatory disorders and cancer, although its exact role is still elusive. Objectives The aim of our study was to understand the role of S1P in healthy versus lung adenocarcinoma cells after Toll‐Like Receptors (TLRs) activation, well‐known modulators of sphingolipid metabolism. Methods We stimulated healthy fibroblast and lung adenocarcinoma cells with TLRs ligands and S1P, to compare physiological vs pathological S1P role. Pro‐inflammatory cytokines release, proliferation rate and the expression/activity of the mediators involved in the S1P signaling were evaluated. Results We found that the activation of TLR9, but not of TLR4, was involved in the generation of S1P by means of ceramidase and sphingosine kinase I/II (SPHK I/II) activation in tumor cells but not in non‐cancerous cells. Through an inside‐out signaling, newly formed S1P was extruded from the cells through its transporter SPNS2, supporting TLR9/NF‐kB‐mediated TNF‐α release mainly via membrane S1PR3. These results were not observed in healthy fibroblasts, implying that this pathway was mainly involved in pathological conditions. Moreover, we found that S1PR3 and SPHK II were overexpressed in the nucleus of lung adenocarcinoma cells and that were associated to S1P‐mediated proliferation of tumor cells. Conclusion These results prove that the endogenous TLR9‐induced S1P can on one side favor pro‐inflammatory mechanisms in the tumor microenvironment via the activation of cell surface receptors, but on the other tumor progression via the nuclear S1PR3/SPHK II axis, highlighting a novel molecular mechanism that identifies S1P as one of the crucial mediators for lung carcinogenesis‐associated inflammatory processes.
Determination of Inorganic Arsenic(III) and Arsenic(V) in Water Samples by Ion Chromatography/Inductively Coupled Plasma-Mass Spectrometry (2007)

A method was validated for the direct determination of As(III) and As(V) in water samples by ion chromatography/inductively coupled plasma-mass spectrometry. Sample preservation required only dilution with a mobile phase containing a sufficient amount of ethylenediaminetetraacetic acid and acetic acid. Analyses of 6 certified reference materials (CRMs) of various water matrixes, including seawater, demonstrated good method accuracy. The matrixes included 2 natural water samples [National Institute of Standards and Technology Standard Reference Material (NIST SRM) 1643e and NIST SRM 1640], 1 fortified standard solution (TMDA-64), 1 fortified water sample (TM-DWS), and 2 seawater samples (CASS-4 and NASS-5). The sum of As(III) and As(V) in each CRM agreed with the respective certified value for the total amount of As within its stated uncertainty. Quantitative recoveries (96.7-102.1%) were obtained. Satisfactory results were achieved for intraday repeatability [relative standard deviation (RSD = 0.3-5.1%] and interday precision (RSD = 0.7-4.1%). In the study of fortified blanks and fortified CRMs, quantitative recoveries of As(III) and As(V) (92.5-102.6%) were obtained. Interconversion of As(III) and As(V) was not observed under the conditions of sample preservation. International comparability of analytical results was demonstrated by the analysis of 2 interlaboratory proficiency test samples, NY7011 and NY8511, from the New York State Department of Health.
Seizures Secondary to Thyrotoxicosis and High-Dosage Propranolol Therapy (1983)

Seizures complicating thyrotoxicosis are uncommon, despite their frequent occurrence in other metabolic encephalopathies. To our knowledge, only eight such case reports have been previously published.<sup>16</sup>We describe an additional patient with classic thyrotoxicosis in whom generalized seizures developed during therapy with high-dosage propranolol hydrochloride, which may have altered his seizure threshold. <h3>REPORT OF A CASE</h3> An 18-year-old man began Basic Training, in June 1980, with symptoms of nervousness, heat intolerance, and a voracious appetite without weight gain. In November 1979, an enlargment had been noted on the anterior part of his neck, but no therapy had been instituted. The patient's medical and neurologic history was otherwise unremarkable, except for an episode of hemorrhagic fever in Thailand in 1979, without sequelae. The initial physical examination demonstrated a resting tachycardia of 140 beats per minute, a fine upper-extremity tremor, and diffuse goiter of 100 g. Hertel exophthalmometric measurements were 19
A class of designs for a sparse distributed memory (1989)

A general class of designs for a space distributed memory (SDM) is described. The author shows that Kanerva's original design and the selected-coordinate design are related, and that there is a series of possible intermediate designs between those two designs. In each such design, the set of addresses that activate a memory location is a sphere in the address space. We can also have hybrid designs, in which the memory locations may be a mixture of those found in the other designs. In some applications, the bits of the read and write addresses that will actually be used might be mostly zeros; that is, the addresses might lie on or near z hyperplane in the address space. The author describes a hyperplane design which is adapted to this situation and compares it to an adaptation of Kanerva's design. To study the performance of these designs, he computes the expected number of memory locations activated by both of two addresses.
Focusing Polycapillary Optics and Their Applications (2010)

A summary of focusing X ray polycapillary optics is presented including history, theory, modeling, and applications development. The focusing effects of polycapillary optics come from the overlap of the beams from thousands of small hollow glass tubes. Modeling efforts accurately describe optics performance to allow for system development in a wide variety of geometries. The focusing of X ray beams with polycapillary optics yields high gains in intensity and increased spatial resolution for a variety of clinical, lab-based, synchrotron or in situ analysis applications.
Supplementary Table S1 from JAK–STAT Signaling in Inflammatory Breast Cancer Enables Chemotherapy-Resistant Cell States (2023)

&lt;p&gt;Supplementary Table S1&lt;/p&gt;