gebhart/patrepeval huggingface dataset:
Quality of service for IP-based networks (2001)

In recent decades, the networking community has been looking for strategies to converge over a single common network infrastructure carrying voice, video and data. The pervasive and ubiquitous packet-based IP network provides the most convenient platform for the desirable convergence, where resources can be managed in an efficient and dynamic manner. The gradual convergence into the IP infrastructure introduces multimedia-rich and interactive applications that are bandwidth-intensive and delay-bound, while more sophisticated data applications are deployed that place new demands onto IP networks. The IP-based network is evolving to satisfy the requirements of traffic differentiation and reliable service. Quality of Service (QoS) mechanisms are introduced to meet the traffic expectations and enhance the basic service model of the network in many subtle ways. This thesis provides a comprehensive examination of QoS mechanisms and protocols that have surfaced to optimize the utilization of network resources, to provide differentiated treatment of traffic and enforce the appropriate policies. The study proposes a balanced approach of bandwidth increase and integration of robust QoS techniques into existing IP network infrastructure to arrive at a convergent, multiservice and scalable telecommunications network. Findings from this thesis can be incorporated into the design and implementation of an integrated network within a large organization that will deliver accurate services and defined level of performances.
The Role of Patient-Derived Organoids in Triple-Negative Breast Cancer Drug Screening (2023)

Triple-negative breast cancer (TNBC) is one of the most aggressive breast cancer subtypes, with a grave prognosis and few effective treatment options. Organoids represent revolutionary three-dimensional cell culture models, derived from stem or differentiated cells and preserving the capacity to differentiate into the cell types of their tissue of origin. The current review aims at studying the potential of patient-derived TNBC organoids for drug sensitivity testing as well as highlighting the advantages of the organoid technology in terms of drug screening. In order to identify relevant studies, a literature review was conducted using the MEDLINE and LIVIVO databases. The search terms "organoid" and "triple-negative breast cancer" were employed, and we were able to identify 25 studies published between 2018 and 2022. The current manuscript represents the first comprehensive review of the literature focusing on the use of patient-derived organoids for drug sensitivity testing in TNBC. Patient-derived organoids are excellent in vitro study models capable of promoting personalized TNBC therapy by reflecting the treatment responses of the corresponding patients and exhibiting high predictive value in the context of patient survival evaluation.
Current tomography in coastal regions (2001)

Reciprocal acoustic transmissions have proved successful for tomography in deep water. However, relatively little effort has been focused on shallow-water environments where sound propagation and scattering takes place often over very short ranges in both the ocean (due to volume and surface) and the seabed. In these regions the effect of depth variations on sound speed is negligible and the salinity and temperature are dominant causes of volume fluctuations. Nevertheless, the methodology can still be utilized to determine the current. In a well-calibrated high-frequency (0.6–18 kHz) acoustic experiment, the range averaged horizontal current in two different directions is determined based on the differential travel times recorded from three reciprocal source–receiver stations. These tripod stations were arranged in a triangular configuration. Data were obtained in nearly isovelocity condition with slight variations in the salinity profile during several tide cycles. The feasibility of obtaining range averaged current profile in very shallow-water regions for long-term measurement is demonstrated. It is also shown that the current can be obtained accurately by utilizing not only the refracted (direct) path, but also the surface reflected arrivals during relatively calm surface conditions. The accuracy of this approach depends on the choice of center frequency and bandwidth of the signal. [Work supported by ONR and Sea Grant.]
Analyzing the Knowing‐Doing Gap of Pedagogy Implementation by Near‐Peer Pre‐Professional Anatomy Lab Teachers (2018)

Training pre‐professional Teaching Assistants (TA's) in the art of pedagogy is a first step toward mastery of the ACGME Core Competencies of Patient Care, and Interpersonal and Communication Skills. The Knowing‐Doing Gap (KDG) of implementing training into practice is a common problem in the field of medical education. We wanted to identify the specific factors that contributed to the KDG for near‐peer pre‐professional Gross Anatomy TA's toward implementing new teaching strategies. A 6‐week pedagogy training program was implemented in which Anatomy Lecture TA's instructed peer Lab TA's on a variety of teaching strategies applicable for any of the three different lab classroom formats: Didactic Lab (DL), Open Lab (OL), unsupervised Free Lab (FL). The goal of the program was to improve the teaching skills of the Lab TA's and identify barriers to pedagogy implementation. Following the completion of the training program, we asked lab TA's to complete an IRB approved reflection through Qualtrics that assessed their implementation of teaching strategies. Questions included both Likert and free response formats. Likert data were expressed as percentage of respondents. Free response data were analyzed using a grounded theory approach, beginning with constructing a word cloud to reveal the most frequent words used in responses that informed subsequent detailed thematic qualitative analysis. Of our 63 Lab TA's, 46 responded (73%) to the survey. We analyzed the use of six teaching strategies. Flipped classroom style and facilitating justification reasoning were used most frequently in DL (17.2%, 48.78%). Peer teaching and gamification were used most frequently in OL (24%, 18.4%). Second order questions and case‐study methods were used most frequently in FL (48.75%, 20.73%). Lab TA's reported that gamification was the most difficult to implement. Across pedagogies, inadequate time to implement, student under‐preparation and/or disinterest in the pedagogical technique as a help for learning the material, were the principal factors that contributed to the KDG in the Anatomy Lab. Future studies will examine methods to overcome barriers toward implementing novel pedagogical techniques. This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .
Dual-band microstrip patch antenna element with double U slots for GSM (2002)

A new dual-band microstrip patch antenna element is presented. The element configuration consists on a rectangular patch with double U slots and coaxial feeding. A prototype was designed, fabricated and tested to be used in a GSM 900/1800 base station antenna. Good agreement has been obtained between theoretical and experimental results. To provide the required bandwidth for both the GSM bands a double-layer structure is under analysis.
ANALYSIS OF THE CONTINUOUS MEASUREMENTS OF PM10 AND PM2.5 CONCENTRATIONS IN BEIRUT, LEBANON (2018)

Atmospheric concentrations of PM2.5 and PM10 were measured in Beirut, Lebanon, for a period of 12 months.The daily average concentrations of PM10 and PM2.5 were found to be 51.3 ± 33.1 and 30.3 ± 9.4 µg.m -3 , respectively, with corresponding maximum values of 359.7 and 208.6 µg.m -3 .The annual average concentrations of PM10 and PM2.5 exceeded the World Health Organization's standards by 150% and 200%, respectively.The mean concentration of coarse particles (PM10-2.5) was found to be 41% of the average PM10, suggesting that the site was also influenced by re-suspended surface dust and soil.The mean PM2.5/PM10 ratio for the entire study period was 0.61 ± 0.12.This indicates that in Beirut, PM2.5 accounts for about 61% of PM10.Such a large fraction of fine particles could have considerable effect on health; thus, it is necessary to quantify its impact.Daily concentrations of PM10 and PM2.5 exceeded the upper threshold limit on 133 and 129 days, respectively, representing 39% and 38% of the entire sample, respectively.These findings indicate the important role dust events play within this area.Concentrations of PM2.5 were highly correlated with NO2, whereas concentrations of PM10 and PM10-2.5 were not associated with any gaseous pollutant.Regression analysis showed that 93% of PM2.5 and 43% of PM10 particle mass concentrations were derived from road traffic exhaust in Beirut.
Productivity in Public, Joint and Private Sectors of Indian Industry: An Assessment of Relative Performance in Pre and Post Reform Periods (2007)

Performance of industrial sector has always assumed importance for achieving fast economic development in India. Its performance has been scrutiny since mid 1980 but the major change in industrial policy in 1991 has made the evaluation of public sector an important policy matter. The present paper compares the performance of public sector with joint and private sector of the Indian industry with the help of different methods, including TFP and production function for the pre and post reform period. It finds that public sector has done quite remarkably if we analyse the growth in TFP and technological progress.
Titelbild: Efficient Encapsulation of Fluorinated Drugs in the Confined Space of Water‐Dispersible Fluorous Supraparticles (Angew. Chem. 51/2017) (2017)

Der Transport fluorierter Wirkstoffe … … in wässrigen Medien erfordert stabile und in Wasser dispergierbare Träger. In ihrer Zuschrift auf S. 16404 beschreiben P. Metrangolo und F. Baldelli Bombelli et al. mit fluorierten Goldnanopartikeln gefüllte Suprapartikel, die mit dem pflanzlichen Protein Hydrophobin II überzogen sind und vom Aufbau her einer Passionsfrucht ähneln. Der fluorreiche Innenraum der Suprapartikel fasst Millionen fluorierter Wirkstoffmoleküle. Der Transport fluorierter Wirkstoffe … … in wässrigen Medien erfordert stabile und in Wasser dispergierbare Träger. In ihrer Zuschrift auf S. 16404 beschreiben P. Metrangolo und F. Baldelli Bombelli et al. mit fluorierten Goldnanopartikeln gefüllte Suprapartikel, die mit dem pflanzlichen Protein Hydrophobin II überzogen sind und vom Aufbau her einer Passionsfrucht ähneln. Der fluorreiche Innenraum der Suprapartikel fasst Millionen fluorierter Wirkstoffmoleküle. Supramolekulare Gele Lithium-Schwefel-Batterien Metall-organische Gerüststrukturen
Fold modulating function: bacterial toxins to functional amyloids (2014)

Many bacteria produce cytolytic toxins that target host cells or other competing microbes. It is well known that environmental factors control toxin expression, however, recent work suggests that some bacteria manipulate the fold of these protein toxins to control their function. The β-sheet rich amyloid fold is a highly stable ordered aggregate that many toxins form in response to specific environmental conditions. When in the amyloid state, toxins become inert, losing the cytolytic activity they display in the soluble form. Emerging evidence suggest that some amyloids function as toxin storage systems until they are again needed, while other bacteria utilize amyloids as a structural matrix component of biofilms. This amyloid matrix component facilitates resistance to biofilm disruptive challenges. The bacterial amyloids discussed in this review reveal an elegant system where changes in protein fold and solubility dictate the function of proteins in response to the environment.
Delta-24-RGD, an Oncolytic Adenovirus, Increases Survival and Promotes Proinflammatory Immune Landscape Remodeling in Models of AT/RT and CNS-PNET (2020)

Delta-24-RGD is a feasible therapeutic option for AT/RTs and CNS-PNETs. This work constitutes the basis for potential translation to the clinical setting.
Spray deposition of water-soluble multiwall carbon nanotube and Cu2ZnSnSe4 nanoparticle composites as highly efficient counter electrodes in a quantum dot-sensitized solar cell system (2013)

In this paper, low-cost counter electrodes (CEs) based on water-soluble multiwall carbon nanotube (MWCNT) and Cu2ZnSnSe4 nanoparticle (CZTSe NP) composites have been successfully introduced into a quantum dot-sensitized solar cell (QDSC) system. Suitable surface modification allows the MWCNTs and CZTSe NPs to be homogeneously dispersed in water, facilitating the subsequent low-temperature spray deposition of high quality composite films with different composite ratios. The electrochemical catalytic activity of the composite CEs has been critically compared by electrochemical impedance spectroscopy and Tafel-polarization analysis. It is found that the composite CE at the MWCNT : CZTSe ratio of 0.1 offers the best performance, leading to an optimal solar cell efficiency of 4.60%, which is 50.8% higher than that of the Pt reference CE. The as-demonstrated higher catalytic activity of the composite CEs compared to their single components could be ascribed to the combination of the fast electron transport of the MWCNTs and the high catalytic activity of CZTSe NPs.
Continuous NAPL loss rates using subsurface temperatures (2015)

To view the abstract, please see the full text of the document.
The Pilot Impacts Portal: Experience in building an emergency management information sharing tool (2013)

Natural disasters have increased in severity and frequency in recent years. In 2010, for example, 385 natural disasters killed over 297 thousand people worldwide, impacted 217 million human lives and cost the global economy an estimated US$123.9 billion (Guha-Sapir et al. 2011). The World Disasters Report (IFRC 2012) notes that in 2011, 15 million people were forced to move worldwide due to hazards and disasters. Recent Australian examples of natural disasters include the decade-long drought (2003-2012), the 2010-2011 floods in Queensland which affected 70 towns, including Brisbane, with an estimated $8 billion in net additional spending for rebuilding (RBA 2011), Cyclone Yasi was originally estimated to cost $800 million for the cost of rebuilding public assets and providing support to the community (Queensland Government 2011, p.66), and Victoria's 2009 Black Saturday bushfires, killing 173 people, impacting 78 towns and having an estimated $2.9 billion in total losses (Stephenson, Handmer and Harwood 2012). This article is an abridged version of a comprehensive report, The Pilot Impacts Portal: Towards an Emergency Response Planning Tool, which describes the portal and project in more detail (Power et al. 2012).
Ghost magnetic resonance angiography (2009)

Traditional methods for magnetic resonance angiography (MRA) involve the radiofrequency excitation of vascular spins within a selected region of tissue, followed by gradient localization and imaging of those spins within that same region. Signals that unfaithfully localize within the imaging volume, so-called "ghost artifacts", have historically been considered undesirable since they degrade image quality and every effort is made to suppress them. To the contrary, we hypothesized that these ghost artifacts could be manipulated to create detailed angiograms of the human body. In this initial demonstration of the method, which we call "Ghost MRA," we show that the human arterial system can be depicted with exquisite anatomic detail and near total suppression of background signal. Moreover, unlike alternative unenhanced methods, Ghost MRA can be acquired without the need for cardiac synchronization.
Expositor: scriptable time-travel debugging with first-class traces (2013)

We present Expositor, a new debugging environment that combines scripting and time-travel debugging to allow programmers to automate complex debugging tasks. The fundamental abstraction provided by Expositor is the execution trace, which is a time-indexed sequence of program state snapshots. Programmers can manipulate traces as if they were simple lists with operations such as map and filter. Under the hood, Expositor efficiently implements traces as lazy, sparse interval trees, whose contents are materialized on demand. Expositor also provides a novel data structure, the edit hash array mapped trie, which is a lazy implementation of sets, maps, multisets, and multimaps that enables programmers to maximize the efficiency of their debugging scripts. We have used Expositor to debug a stack overflow and to unravel a subtle data race in Firefox. We believe that Expositor represents an important step forward in improving the technology for diagnosing complex, hard-to-understand bugs.
Metal-insulator transition and size dependent electrical percolation in onion-like carbon/polydimethylsiloxane composites (2014)

Dielectric/electric properties of onion-like carbon (OLC)/polydimethylsiloxane composites were investigated over very wide frequency (20 Hz–3 THz) and temperature (26–500 K) ranges. The percolation threshold in these composites strongly dependents on the OLC aggregate sizes and was lowest for the composites with the smallest OLC aggregate sizes (∼40 nm). Interestingly, the transition into the insulator state of the composites occurred at higher temperatures. The transition temperature increases with OLC aggregate concentration. Above the percolation threshold, the electrical conductivity in the composites occurs mainly due to electron tunneling between OLC clusters and quasi-one-dimensional hopping inside the clusters. The hopping almost vanishes at frequencies above 100 GHz where the phonon contribution dominates.
Facets of individual-specific health signatures determined from longitudinal plasma proteome profiling (2020)

This work was supported by the Erling Persson Foundation, the Swedish Heart and Lung Foundation, the Knut and Alice Wallenberg Foundation, Science for Life Laboratory, and the Swedish Research Council.
A UAU test and development environment based on dynamic system reconfiguration (2005)

This paper describes ongoing research to develop a framework for implementing dynamically reconfiguring avionics and control systems for unmanned aerial vehicles (UAVs) and a test and development environment for experimental UAVs. The framework supports graceful degradation, where hardware and software failures cause a reduction in the quality or capability of the control system but does not result in total system failure. The approach uses a graphical specification representing modular software interdependencies and a runtime system manager that reconfigures the system. The techniques are currently being applied to the design of UAV control systems as part of the BIG BLUE Mars airplane testbed project at the University of Kentucky.
Quantitative tumorigenicity assays using the anterior chamber of the mouse eye. (1968)

Using a quantitative technic for depositing a definite number of carcinoma or sarcoma cells into the anterior chamber of the mouse eye, without leakage as proven by complete retention of Trypan blue dye, this route generally required a 100- to 1,000-fold lower dose of cells to produce tumors in 100% of animals, as compared to the intramuscular, intravenous, and intraperitoneal routes of inoculation in both irradiated and nonirradiated mice. Neoplastic transformation of a cultured mouse cell line was demonstrated using the quantitative anterior chamber technic.
Trapping Laser-cooled Atoms With Microwave Radiation (1994)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text M. Reynolds, I. Silvera, R. Spreeuw, C. Gerz, L Coldner, W. Phillips, S. Rolston, and C. Westbrook, "Trapping Laser-cooled Atoms With Microwave Radiation," Optics & Photonics News 5(12), 25-25 (1994) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Virologic characterization of genotype 4 hepatitis C virus variants in patients treated with telaprevir (2014)

The trial was registered with ClinicalTrials.gov (NCT00580801).
Hyperinsulinemia compensates for infection-induced impairment in net hepatic glucose uptake during TPN (2000)

In animals receiving total parenteral nutrition (TPN), infection impairs net hepatic glucose uptake (NHGU) by 40% and induces mild hyperinsulinemia. In the normal animal, the majority of the glucose taken up by the liver is diverted to lactate, but in the infected state, lactate release is curtailed. Because of the hyperinsulinemia and reduced NHGU, more glucose is utilized by peripheral tissues. Our aims were to determine the role of infection-induced hyperinsulinemia in 1) limiting the fall in NHGU and hepatic lactate release and 2) increasing the proportion of glucose disposed of by peripheral tissues. Chronically catheterized dogs received TPN for 5 days via the inferior vena cava. On day 3, a fibrin clot with a nonlethal dose of E. coli was placed into the peritoneal cavity; sham dogs received a sterile clot. On day 5, somatostatin was infused to prevent endogenous pancreatic hormone secretion, and insulin and glucagon were replaced at rates matching incoming hormone concentrations observed previously in sham or infected dogs. The TPN-derived glucose infusion was adjusted to maintain a constant arterial plasma glucose level of approximately 120 mg/dl. after a basal blood sampling period, the insulin infusion rate was either maintained constant (infected time control, Hi-Ins, n = 6; sham time control, Sham, n = 6) or decreased (infected + reduced insulin, Lo-Ins; n = 6) for 180 min to levels seen in noninfected dogs (from 23 +/- 2 to 12 +/- 1 microU/ml). Reduction of insulin to noninfected levels decreased NHGU by 1.4 +/- 0.5 mg x kg(-1) x min(-1) (P < 0.05) and nonhepatic glucose utilization by 4.8 +/- 0.8 mg x kg(-1) x min(-1) (P < 0.01). The fall in NHGU was caused by a decline in HGU (Delta-0.6 +/- 0.4 mg x kg(-1) x min(-1)) and a concomitant increase in hepatic glucose production (HGP, Delta0.8 +/- 0.5 mg x kg(-1) x min(-1)); net hepatic lactate release was not altered. Hyperinsulinemia that accompanies infection 1) primarily diverts glucose carbon to peripheral tissues, 2) limits the fall in NHGU by enhancing HGU and suppressing HGP, and 3) does not enhance hepatic lactate release, thus favoring hepatic glucose storage. Compensatory hyperinsulinemia plays a critical role in facilitating hepatic and peripheral glucose disposal during an infection.
From Seismic Impedances to Reservoir Porosities - the Road Is not Always Straight (1996)

Seismic data are nowadays commonly used to improve the reservoir image between wells, with techniques for quantitative lithologie interpretation. In particular, when the reservoir is not too heterogeneous, it is standard to use seismic derived acoustic impedances to predict reservoir properties such as average porosities [1, 2], Acoustic impedances are extracted from post-stack seismic amplitudes with inversion techniques. Then, they are turned into porosities with a regression approach (simple regression or eventually cokriging) after a calibration in the vicinities of wells. In this paper, a case study is used to examine some difficulties in this approach and to carry out sensitivity tests for defining critical parameters in the prediction of seismic porosities.