gebhart/patrepeval huggingface dataset:
Analysis of interphase cells for the Philadelphia translocation using painting probe made by inter-Alu-polymerase chain reaction from a radiation hybrid (1994)

Fluorescence in situ hybridization (FISH) probe for the identification of the Philadelphia (Ph) translocation [t(9;22) (q34;q11)] in chronic myelogenous leukemia cells was developed by inter-Alu-polymerase chain reaction of DNA from an interspecific somatic cell hybrid containing approximately 5 Mb of human DNA covering the ABL gene region on human chromosome 9q34. This probe was large enough to be effective in identifying the genomic domains yet small enough to resolve them in more than 90% of bone marrow interphase cells. Combination of the probe with a cosmid contig probe for the BCR region of chromosome 22 in two-color FISH reduced the frequency of false-positive identification of the Ph chromosome to less than 1%. The procedure allows detection of as few as 1% Ph+ cells independent of the cycling status or BCR/ABL expression level of cells, and the quantitation of non-Ph chromosome-containing interphase nuclei in the marrow of patients judged 100% Ph+ by standard cytogenetics.
Defocus video matting (2005)

Video matting is the process of pulling a high-quality alpha matte and foreground from a video sequence. Current techniques require either a known background (e.g., a blue screen) or extensive user interaction (e.g., to specify known foreground and background elements). The matting problem is generally under-constrained, since not enough information has been collected at capture time. We propose a novel, fully autonomous method for pulling a matte using multiple synchronized video streams that share a point of view but differ in their plane of focus. The solution is obtained by directly minimizing the error in filter-based image formation equations, which are over-constrained by our rich data stream. Our system solves the fully dynamic video matting problem without user assistance: both the foreground and background may be high frequency and have dynamic content, the foreground may resemble the background, and the scene is lit by natural (as opposed to polarized or collimated) illumination.
Bioinformatic pipelines for whole transcriptome sequencing data exploitation in leukemia patients with complex structural variants (2019)

Byapplying our methods to real clinical samples, we proved that our approach for total RNA-Seq data analysis generates results consistent with other genomic analytical techniques. The data obtained by our analyses provided clues for the study of the biological consequences of cSVs with far-reaching implications for clinical outcome and management of cancer patients. The bioinformatic workflow is also widely applicable for addressing other research questions in different contexts, for which transcriptomic data are generated.
A phase Ib study of telatinib (BAY 57–9352), a VEGFR-2 inhibitor, in combination with docetaxel in patients with advanced solid tumours (2007)

14035 Background: Telatinib (BAY 57–9352) inhibits VEGFR-2 and VEGFR-3 tyrosine kinases, and PDGFR-β and c-Kit. Preclinical data suggests that targeting VEGFR signaling increases antitumor activity. Methods: This trial investigated the safety, pharmacokinetics (PK), and tumor efficacy of telatinib combined with docetaxel (D). D was administered at a fixed dose of 75mg/m 2 on day 1 of 21-day cycles. Telatinib was administered orally, twice daily (bid) from day 3 of Cycle 1 and onwards, thereafter continuously. Dosing of telatinib commenced at 600mg bid (cohort 1, n=6) and increased to 900mg bid (cohort 2, n=7). PK in Cycle 1 were determined on day 1 (D) and day 21 (telatinib). In Cycle 2 comparative PK profiles for both telatinib and D were sampled on days 1–3. Results: Thirteen patients (pts) with advanced solid tumors were enrolled (9M/4F; median age: 56 [range: 34–69]; ECOG PS 0/1: 3/10). A total of 69 cycles have been completed (range,1–10). Treatment-emergent adverse events of CTCAE =3 (NCI-CTC v3.0) were neutropenia (n=11, 79%), fever (n=2, 15%), and fatigue (n=2, 11%). Adverse events of CTC =3 occuring in two pts was febrile neutropenia. Others occurring in only one patient were; hypertension, ALT increase, dehydration, and reversible symptomatic pneumonitis. Study treatment-related adverse events leading to a dose reduction or interruption were neutropenia (n=5, 38%), hypertension (n=1), ALT increase (n=1), and fatigue (n=1). Two pts with prostate ca and 1 with cervical ca had a confirmed partial response. Five pts (1 NSCLC, 1 esophageal ca, 1 renal cell ca and 2 prostate ca) had stable disease for =4 cycles. Mean AUC of D increased by 48% in cohort 1, but only by 16% in cohort 2. Thus, PK data to date do not indicate a clear clinically relevant interaction between telatinib and D. Conclusions: The combination of telatinib and D was tolerated without reaching the toxic dose at telatinib 900mg bid and D 75mg/m 2 . This combination has demonstrated promising antitumor activity. An extension of the cohort at 900mg bid with 75mg/m 2 D is being evaluated to gain further safety and PK data. No significant financial relationships to disclose.
A LAMP-assay-based specific microbiota analysis reveals community dynamics and potential interactions of 13 major soybean root pathogens (2020)

Soybean root diseases are associated with numerous fungal and oomycete pathogens; however, the community dynamics and interactions of these pathogens are largely unknown. We performed 13 loop-mediated isothermal amplification (LAMP) assays that targeted specific soybean root pathogens, and traditional isolation assays. A total of 159 samples were collected from three locations in the Huang-Huai-Hai region of China at three soybean growth stages (30, 60, and 90 days after planting) in 2016. In LAMP results, we found that pathogen communities differed slightly among locations, but changed dramatically between soybean growth stages. Phytophthora sojae, Rhizoctonia solani, and Fusarium oxysporum were most frequently detected at the early stage, whereas Phomopsis longicolla, Fusarium equiseti, and Fusarium virguliforme were most common in the later stages. Most samples (86%) contained two to six pathogen species. Interestingly, the less detectable species tended to exist in the samples containing more detected species, and some pathogens preferentially co-occurred in diseased tissue, including P. sojae–R. solani–F. oxysporum and F. virguliforme–Calonectria ilicicola, implying potential interactions during infection. The LAMP detection results were confirmed by traditional isolation methods. The isolated strains exhibited different virulence to soybean, further implying a beneficial interaction among some pathogens.
Nonlinear Modeling of Eddy-Current Couplers (2014)

Analytical models play an important role in the design of electromagnetic devices by providing computationally efficient solutions. In this paper, by combining magnetic equivalent circuit approaches and Faraday's and Ampere's laws, a model for radial-flux eddy-current couplers is developed, which can easily handle complex geometries as well as account for iron saturation, all material properties, and three-dimensional (3-D) parameters. The characteristics and the design considerations of a surface-mounted permanent-magnet structure are presented. Also, a procedure aimed at an optimal design of the yoke thicknesses is utilized. Moreover, 2-D and 3-D finite-element methods are employed in the analyses and evaluation of the model. Finally, sensitivity analysis is performed to explore the impacts of the machine parameters on the device performance.
Effects of radiation and MediPort placement on the development of thoracic outlet syndrome (2020)

We present a patient who exemplifies the interplay of factors contributing to the development of venous-type thoracic outlet syndrome. The patient was treated with both radiation and chemotherapy for squamous cell carcinoma in the head and neck region; radiation and chemotherapy have been known to damage the vascular system. Multimodality treatment is necessary to achieve good long-term results in these complex patients.
Preparation and Characterization of 12-Molybdophosphoric and 12-Molybdosilicic Acids and Their Metal Salts (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and Characterization of 12-Molybdophosphoric and 12-Molybdosilicic Acids and Their Metal SaltsGeorge A. TsigdinosCite this: Ind. Eng. Chem. Prod. Res. Dev. 1974, 13, 4, 267–274Publication Date (Print):December 1, 1974Publication History Published online1 May 2002Published inissue 1 December 1974https://pubs.acs.org/doi/10.1021/i360052a011https://doi.org/10.1021/i360052a011research-articleACS PublicationsRequest reuse permissionsArticle Views1142Altmetric-Citations140LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
The Cyclope : A 6 DOF Optical Tracker Based on a Single Camera (2005)

International audience
THE INVESTIGATION OF THE FAST ELECTRONS ENERGY DISTRIBUTION IN THE POSITIVE COLUMN AND NEGATIVE GLOW OF THE LOW PRESSURE HELIUM DISCHARGE (1979)

No abstract available
Covariance sequence approximation for parametric spectrum modeling (1981)

Parametric methods of spectrum analysis are founded on finite-dimensional models for covariance sequences. Rational spectrum approximants for continuous spectra are based on autoregressive (AR), moving average (MA), or autoregressive moving average (ARMA) models for covariance sequences. Line spectrum approximants to discrete spectra are based on cosinusoidal models for covariance sequences. In this paper we make the point that a wide variety of spectrum types admit to modal analysis wherein the modes are characterized by amplitudes, frequencies, and damping factors. The associated modal decomposition is appropriate for both continuous and discrete components of the spectrum. The domain of attraction for the decomposition includes ARMA sequences, harmonically or nonharmonically related sinusoids, damped sinusoids, white noise, and linear combinations of these. The parametric spectrum analysis problem now becomes one of identifying mode parameters. This we achieve by solving two modified least squares problems. Numerical results are presented to illustrate the identification of mode parameters and corresponding spectra from finite records of perfect and estimated covariance sequences. The results for sinusoids and sinusoids in white noise are interpreted in terms of in-phase and quadrature effects attributable to the finite record length.
Chemistry of metal hydrides. XIII. Insertion and isomerization reactions of allylic compounds with cationic platinum(II)-hydrido complexes (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry of metal hydrides. XIII. Insertion and isomerization reactions of allylic compounds with cationic platinum(II)-hydrido complexesH. C. Clark and H. KurosawaCite this: Inorg. Chem. 1973, 12, 2, 357–362Publication Date (Print):February 1, 1973Publication History Published online1 May 2002Published inissue 1 February 1973https://pubs.acs.org/doi/10.1021/ic50120a024https://doi.org/10.1021/ic50120a024research-articleACS PublicationsRequest reuse permissionsArticle Views190Altmetric-Citations53LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Characterization of olivetol synthase, a polyketide synthase putatively involved in cannabinoid biosynthetic pathway (2009)

Alkylresorcinol moieties of cannabinoids are derived from olivetolic acid (OLA), a polyketide metabolite. However, the polyketide synthase (PKS) responsible for OLA biosynthesis has not been identified. In the present study, a cDNA encoding a novel PKS, olivetol synthase (OLS), was cloned from Cannabis sativa. Recombinant OLS did not produce OLA, but synthesized olivetol, the decarboxylated form of OLA, as the major reaction product. Interestingly, it was also confirmed that the crude enzyme extracts from flowers and rapidly expanding leaves, the cannabinoid-producing tissues of C. sativa, also exhibited olivetol-producing activity, suggesting that the native OLS is functionally expressed in these tissues. The possibility that OLS could be involved in OLA biosynthesis was discussed based on its catalytic properties and expression profile.
Assembled Chemical Weapons Assessment (ACWA) Program, Immobilized Cell Bioreactor Toxicity Monitoring (2003)

Until recently, incineration was the only proven technology, adopted by the U.S. Army, that successfully destroyed chemical agents. However, public opposition to incineration redirected research to evaluate alternative technologies. Through the Alternative Technology Program, the U.S. Army adopted biodegradation as a proven method for destroying the mustard stockpile at Aberdeen Proving Ground. However, research did not address the destruction of mustard when mixed with explosives generated from the destruction of Assembled Chemical Weapons. The Assembled Chemical Weapons Assessment (ACWA) Program was tasked to find alternatives to the incineration/destruction of assembled chemical weapons. The ACWA Program has been evaluating biodegradation to determine if tetrytol (explosive) will disrupt the biodegradation process. Microtox (MTX) assays were used to monitor changes in toxicity due to changes in feed composite. The MTX assay uses a luminescent marine bacteria (vibrio fischeri) that can survive high salt concentrations. When subjected to toxic substances, cellular respiration decreases, resulting in a corresponding decrease in luminescence. Feed and effluent samples were monitored for toxicity using the MTX assays over a 42-day period.
Linkage of the MHC to familial multiple sclerosis suggests genetic heterogeneity. The Multiple Sclerosis Genetics Group (1998)

Multiple sclerosis (MS) is a demyelinating autoimmune disease of the central nervous system. While its etiology is not well understood, genetic factors are clearly involved. Until recently, most genetic studies in MS have been association studies using the case-control design testing specific candidate genes and studying only sporadic cases. The only consistently replicated finding has been an association with the HLA-DR2 allele within the major histocompatibility complex (MHC) on chromosome 6. Using the genetic linkage design, however, evidence for and against linkage of the MHC to MS has been found, fostering suggestions that sporadic and familial MS have different etiologies. Most recently, two of four genomic screens demonstrated linkage to the MHC, although specific allelic associations were not tested. Here, a dataset of 98 multiplex families was studied to test for an association to the HLA-DR2 allele in familial MS and to determine if genetic linkage to the MHC was due solely to such an association. Three highly polymorphic markers (HLA-DR, D6S273 and TNFbeta) in the MHC demonstrated strong genetic linkage (parametric lod scores of 4.60, 2.20 and 1.24, respectively) and a specific association with the HLA-DR2 allele was confirmed (TDT; P < 0.001). Stratifying the results by HLA-DR2 status showed that the linkage results were limited to families segregating HLA-DR2 alleles. These results demonstrate that genetic linkage to the MHC can be explained by the HLA-DR2 allelic association. They also indicate that sporadic and familial MS share a common genetic susceptibility. In addition, preliminary calculations suggest that the MHC explains between 17 and 62% of the genetic etiology of MS. This heterogeneity is also supported by the minority of families showing no linkage or association with loci within the MHC.
Second and third harmonic generation at UV and soft x-ray wavelengths from semiconductor gratings (2011)

Extraordinary transmission properties are demonstrated in the UV range for GaAs gratings with sub-wavelength apertures under TM-polarization excitation. The metal-like response below 270nm, typical of several semiconductors such as GaAs or GaP, in fact may be used to excite surface waves that lead to enhance transmission in the linear regime and for novel nonlinear optical phenomena in the UV and soft X-ray ranges. An investigation of the linear transmission as a function of geometrical parameters of the grating reveals the formation of surface waves and relatively high transmission values even in regimes where the nominal absorption is significant. Strong field localization in subwavelength cavities and on the surface of the grating can be achieved under proper excitation conditions leading to the enhancement of harmonic generation. Nonlinear contributions to harmonic generation arise from symmetry breaking, the nonlinear magnetic Lorentz force, and from intrinsic, dipolar volume contributions. Preliminary results show promising nonlinear conversion efficiencies at wavelengths below 100nm, and demonstrate cross-coupling of TE and TM polarizations for pump and harmonic signals. A down-conversion process that can re-generate pump photons of polarization orthogonal compared to the incident pump field is also demonstrated.
Hemorrhage in a patient with Bronchial Dieulafoy's disease and associated pulmonary fibrosis: A case report (2022)

This report describes a novel case of BDD leading to bronchial hemorrhage. Considering the endoscopic differential diagnosis, including rather frequent carcinoid tumor and broncholithiasis, we highlight the need for extreme caution when considering endoscopic biopsy of protruding white lesions. Indeed, biopsy - or even contact - with a BDD lesion is frequently associated with massive hemorrhage. According to our review, BDD is the most hemorrhage-prone lesion when biopsied, associated with significant bleeding in 90% of cases and 30% mortality, compared with significant bleeding in only 2.6% of carcinoid tumors and 3.1% of broncholithiasis cases.This case of BDD is also original since associated with idiopathic pulmonary fibrosis. It is to our knowledge the first time that such an association has been reported.
Effects of Topical Applications of Epidermal Growth Factor on Wound Healing Experimental Study on Rabbit Ears (1979)

In wounds in rabbit ears, the application every 12 hours of an ointment containing epidermal growth factor appears to produce faster and better healing. The resulting epithelium is thicker and more cellular than in the untreated ear wounds, and more fibroblasts appeared sooner during the healing process. Less wound contracture occurred in the EFG-treated wounds, and wound maturation occurred earlier. The healed wounds that had been treated with EGF more closely resembled the surrounding normal tissue, producing less local deformity than in the controls. It is too early to know whether this will have clinical application, but other experiments are under way to further investigate the effects of EGF on wound healing.
Version Control and Management in Computer-aided Design Databases (2019)

There are essentially two characteristics of design objects which impact upon the iterative and probative nature of the design process. First, they are hierarchically formed assemblies of component objects. Second, they have several alternative representations. This dissertation addresses a broad spectrum of modeling and operational issues related to these two aspects in computer-aided design databases.
A formal treatment of datamodeling concepts, which are defined in terms of primitive constructs of instances, types, homogeneous sets and functions, and abstractions of generalization and composition, is presented for design applications.
A classification of composite object attributes into intrinsic interface and extrinsic internal assembly provides an insight into their behavior and functionality. The design process is studied with respect to these classes of attributes. A design evolves in discrete states through mutation and derivation, which may cause version proliferation in the absence of any control mechanism. Concepts of invariant attributes and value acquisition are found to be useful for developing a notion of version equivalence. A wide range of methodologies for version management and solutions for the related problems are discussed.
The interdependence between composition and generalization graphs suggests that the effect of updates in these graphs on each other must be evaluated for maintaining consistency. A time complexity analysis of algorithms devised for this purpose shows a considerably improved performance when the stored, rather than the dynamically computed, transitive closures of these graphs are used. The trade-off it provides far outweighs the space requirement of the transitive closure relations.
Owing to the sheer complexity and size of design databases, efficient organization and access of versioned composite objects become imperative. The proposed scheme and its related algorithms can determine an optimal storage organization based on significant units of clustering and expected frequency of retrieval and update operations.
A multi-layer architecture is motivated by the accessibility and stability of versions they contain. The proposed protocols for sharing and transition of versions together with change notification provide a unifying framework for managing design in a cooperative CAD environment.
Remote prognosis after primary cesarean delivery: the association of VBACs and recurrent cesarean deliveries with maternal morbidity (2012)

(1) A successful VBAC is associated with a reduction in the intrapartum complications; and (2) maternal morbidity increases substantially from the fourth consecutive cesarean delivery.