gebhart/patrepeval huggingface dataset:
OPS/OBS scheduling algorithms: Incorporating a wavelength conversion cost in the performance analysis (2013)

With ever-increasing demands for bandwidth optical packet/burst switching is used to utilise more of the available capacity of optical networks. In current prototypes of optical switches time and wavelength multiplexing are combined to resolve packet contentions by means of Fiber Delay Lines and wavelength converters in the switching elements. Although optical switches have lower energy consumption than their electronic counterparts, it remains substantial. Since wavelength converters contribute significantly to the switches overall energy consumption, they should be used sparingly, rather than continuously. Current scheduling algorithms however do not take the usage of wavelength converters (and the related energy consumption) into account. To this end, we developed and evaluated new cost-based scheduling algorithms, which take both gap and delay into account to schedule an incoming packet. The performance improvement of these algorithms over existing algorithms can be traded off for a significant reduction in up-time of the wavelength converters by introducing a conversion cost in the involved cost function. This is backed by Monte Carlo simulation results, in which the algorithms are applied both in a void-filling and non-void-filling setting. The algorithms are of the same implementation complexity as current algorithms, and thus of immediate value to switch designers.
Chemical Synthesis of De–Doped Polyaniline for High Performance Aqueous Supercapacitive Material (2018)

De-doped polyaniline were prepared by processing the doped polyaniline with three different aqueous alkali: NH4OH, NaOH and NaHCO3. Compared with the doped polyaniline, de-doped polyaniline shows better electrochemical capacitor performance, lower resistance and better stability in 0.5 M H2SO4 aqueous solution. Especially, de-doped polyaniline treated by NH3 center dot H2O exhibits the specific capacitance of 839 F g(-1) at a current density of 3 mA cm(-2), which is about 2-fold higher than that of doped polyaniline. The behaviors of the capacitance of de-doped polyaniline can be deeply investigated and explained by the organic semiconductor band theory. De-doped polyaniline is expected to show satisfying performance due to the formation of impurity levels that can reduce the gap width of the forbidden band, and holes formed in the valence band generate the hole conduction during the re-doping of the de-doped polyaniline in acidic electrolyte, all of which can increase electron transport capacity. The study reveals that the electrochemical performances of polyaniline, particularly capacitance, can be improved by a simple de-doping process. (C) 2018 The Electrochemical Society.
The v-erbB oncogene confers enhanced cellular susceptibility to reovirus infection (1996)

We have previously demonstrated that two mouse cell lines that are poorly infectible by reovirus become highly susceptible upon transfection with the gene encoding the epidermal growth factor receptor (EGFR) (J. E. Strong, D. Tang, and P. W. K. Lee, Virology 197:405-411, 1993). This enhancement of infection efficiency requires a functional EGFR, since such an enhancement is not observed in cells expressing a mutated (kinase-inactive) EGFR. The additional finding that reovirus is capable of directly binding to the N-terminal ectodomain of the EGFR (D. Tang, J. E. Strong, and P. W. K. Lee, Virology 197:412-414, 1993) has led us to question whether this interaction is required for the activation of a signalling cascade that somehow augments the ensuing infection process. In the present study, we address this question, using cells transfected with the v-erbB oncogene, which encodes a protein structurally related to the EGFR but lacking a large portion of the N-terminal ligand-binding domain. The v-erbB protein also possesses ligand-independent, constitutive tyrosine kinase activity. Control NIH 3T3 cells, which are poorly infectible by reovirus (serotype 3, strain Dearing), and NIH 3T3 cells transfected with the v-erbB oncogene (THC-11) were assayed for their susceptibilities to reovirus infection. Infectivity was determined by immunofluorescent detection of viral proteins, sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis of radiolabeled cells, and plaque titration. All three assays demonstrated a drastically higher degree of susceptibility to infection in the THC-11 cell line. This enhanced susceptibility was found to be abrogated by treatment of the cells with genistein, an inhibitor of tyrosine protein kinases, but only partially by treatment with daidzein, an inactive analog of genistein. We propose that the mechanism of enhancement of infection efficiency conferred by EGFR and v-erbB is through the opportunistic utilization by the virus of an already activated signal transduction pathway.
Current and emerging options for patients with melanoma brain metastases. (2022)

Melanoma is the most aggressive skin cancer, with a high incidence of metastatic spread and a predilection for metastases to the brain. It represents the third most common origin of brain metastases after breast and lung cancer. With the advent of targeted therapy and immunotherapy in melanoma, along with improved local therapy options such as stereotactic radiosurgery (SRS), the treatment of melanoma brain metastases (MBM) has led to significant improvements in outcome. In this review, we provide an overview of management options for patients with MBM while highlighting emerging treatment options. Surgery may be considered for patients with symptomatic MBM, whereas SRS is considered standard for patients with 1 to 4 brain lesions. Combination immunotherapy has led to durable intracranial responses and improved long-term outcomes for patients with asymptomatic MBM. The data available to date have shown that patients with MBM can have a durable response and overall response that are similar to those of patients without brain metastases, and additional trials are ongoing. Mounting evidence suggests that patients with MBM should be considered for inclusion in clinical trials, which range from early-phase trials to phase 3 studies, to accelerate much-needed drug development in this population.
Metal sensor proteins: nature's metalloregulated allosteric switches (2007)

Metalloregulatory proteins control the expression of genes that allow organisms to quickly adapt to chronic toxicity or deprivation of both biologically essential metal ions and heavy metal pollutants found in their microenvironment. Emerging evidence suggests that metal ion homeostasis and resistance defines an important tug-of-war in human host-bacterial pathogen interactions. This adaptive response originates with the formation of "metal receptor" complexes of exquisite selectivity. In this perspective, we summarize consensus structural features of metal sensing coordination complexes and the evolution of distinct metal selectivities within seven characterized metal sensor protein families. In addition, we place recent efforts to understand the structural basis of metal-induced allosteric switching of these metalloregulatory proteins in a thermodynamic framework, and review the degree to which coordination chemistry drives changes in protein structure and dynamics in selected metal sensor systems. New insights into how metal sensor proteins function in the complex intracellular milieu of the cytoplasm of cells will require a more sophisticated understanding of the "metallome" and will benefit greatly from ongoing collaborative efforts in bioinorganic, biophysical and analytical chemistry, structural biology and microbiology.
Primer on Three-Dimensional Geometry (2017)

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Case series of seven women with uterine fibroids associated with venous thromboembolism and chronic thromboembolic disease (2018)

Uterine fibroids have been described as an associate to acute venous thromboembolism (VTE), with case reports showing an association between large uterine fibroids, acute deep venous thrombosis (DVT), and acute pulmonary embolism (PE). However, there is little known about the association or causation between uterine fibroids, chronic thromboembolic disease (CTED), and chronic thromboembolic pulmonary hypertension (CTEPH). We report on six women with uterine fibroids and CTEPH, as well as one woman with CTED, all of whom presented with exertional dyspnea, lower extremity swelling, and in the cases of CTEPH, clinical, echocardiographic, and hemodynamic evidence of pulmonary hypertension and right heart failure. Compression of the pelvic veins by fibroids was directly observed with invasive venography or contrast-enhanced computed tomography in five cases. All seven women underwent pulmonary thromboendarterectomy (PTE) followed by marked improvement in functional, clinical, and hemodynamic status.
Altered mitochondrial RNA production in adipocytes from HIV-infected individuals with lipodystrophy. (2005)

Lipodystrophy following treatment with NRTI-containing HAART is associated with a decrease in adipose tissue mtRNAs.
Laser micromachining of thin substrates for microelectronics applications (2014)

Poster
CYP2U1 activity is altered by missense mutations in hereditary spastic paraplegia 56 (2017)

Hereditary spastic paraplegia (HSP) is an inherited disorder of the central nervous system mainly characterized by gradual spasticity and weakness of the lower limbs. SPG56 is a rare autosomal recessive early onset complicated form of HSP caused by mutations in CYP2U1. The CYP2U1 enzyme was shown to catalyze the hydroxylation of arachidonic acid. Here, we report two further SPG56 families carrying three novel CYP2U1 missense variants and the development of an in vitro biochemical assay to determine the pathogenicity of missense variants of uncertain clinical significance. We compared spectroscopic, enzymatic, and structural (from a 3D model) characteristics of the over expressed wild-type or mutated CYP2U1 in HEK293T cells. Our findings demonstrated that most of the tested missense variants in CYP2U1 were functionally inactive because of a loss of proper heme binding or destabilization of the protein structure. We also showed that functional data do not necessarily correlate with in silico predictions of variants pathogenicity, using different bioinformatic phenotype prediction tools. Our results therefore highlight the importance to use biological tools, such as the enzymatic test set up in this study, to evaluate the effects of newly identified variants in clinical settings.
Mathematical model of pulsatile blood pump for LVAS control (1997)

A mathematical model describing the pressure-volume relationship of the Novacor left ventricular assist system (LVAS) was developed. The model consisted of lumped resistance, capacitance, and inductance elements with one time-varying capacitor to simulate the cyclical pressure generation of the system. The ejection and filling portions of the pump cycle were modeled with two separate functions. The corresponding model parameters were estimated by least squares fit to experimental data obtained in the laboratory. The model performed well in simulating pump pressure of operation throughout the full cycle. This model can be used to incorporate online cardiovascular model parameter estimation and to design a rule-based controller for the LVAS.
The role of p27Kip1 in proteasome inhibitor induced apoptosis. (2004)

Proteasome inhibitors are potent inducers of cell death. The cytotoxic effect of proteasome inhibitors in general appears to be selective for proliferating cells, while quiescent cells seem to be protected. Conflicting results have been reported on the role of the CKI p27Kip1 either in promoting or inhibiting apoptosis mediated by proteasome inhibitors and other drugs. Here I discuss the role of p27Kip1 in apoptosis and chemotherapy of cancer.
Efficient quantum cryptography with coherent-state light in optical fibers at Gbps rates (2004)

We demonstrate high-speed (0.25Gbps) data encryption over 50km of telecom fiber using coherent states of light. For the parameter values used in the experiment, the demonstration is secure against individual ciphertext-only eavesdropping attacks near the transmitter with ideal detection equipment. While other quantum cryptographic schemes require the use of fragile quantum states and ultra-sensitive detection equipment, our protocol is loss tolerant, uses off-the-shelf components, and is optically amplifiable.
Towards a muon collider (2023)

&lt;p&gt;A muon collider would enable the big jump ahead in energy reach that is needed for a fruitful exploration of fundamental interactions. The challenges of producing muon collisions at high luminosity and 10 TeV centre of mass energy are being investigated by the recently-formed International Muon Collider Collaboration. This Review summarises the status and the recent advances on muon colliders design, physics and detector studies. The aim is to provide a global perspective of the field and to outline directions for future work.&lt;/p&gt;
Data Modeling Strategies for Imbalanced Learning in Visual Search (2007)

In this paper we examine a novel approach to the difficult problem of querying video databases using visual topics with few examples. Typically with visual topics, the examples are not sufficiently diverse to create a robust model of the user's need. As a result, direct modeling using the provided topic examples as training data is inadequate. Otherwise, systems resort to multiple content-based searches using each example in turn, which typically provides poor results. We propose a new technique of leveraging unlabeled data to expand the diversity of the topic examples as well as provide a robust set of negative examples that allow direct modeling. The approach intelligently models a pseudo-negative space using unbiased and biased methods for data sampling and data selection. We apply the proposed method in a fusion framework to improve discriminative support vector machine modeling, and improve the overall system performance. The result is an enhanced performance over any of the baseline models, as well as improved robustness with respect to training examples, visual features, and visual support of video topics in TRECVID. The proposed method outperforms a baseline retrieval approach by more than 18% on the TRECVID 2006 video collection and query topics.
Addressing the challenges of DBT for the ARM architecture (2009)

Dynamic binary translation (DBT) can provide security, virtualization, resource management and other desirable services to embedded systems. Although DBT has many benefits, its run-time performance overhead can be relatively high. The run-time overhead is important in embedded systems due to their slow processor clock speeds, simple microarchitectures, and small caches. This paper addresses how to implement efficient DBT for ARM-based embedded systems, taking into account instruction set and cache/TLB nuances. We develop several techniques that reduce DBT overhead for the ARM. Our techniques focus on cache and TLB behavior. We tested the techniques on an ARM-based embedded device and found that DBT overhead was reduced by 54% in comparison to a general-purpose DBT configuration that is known to perform well, thus further enabling DBT for a wide range of purposes.
Towards the Development of Personal Cloud Computing for Mobile Thin-Clients (2011)

The phenomenon of cloud computing has been driven largely these days. Personal Cloud, as the cloud computing for personal usage, has come to the forefront. Compare with traditional operating system, personal cloud shifts individual computing "from being device-centric to information-centric", which create a bridge between operating system-based computing and the more service-oriented approach to IT. Also, the mobile thin-client has brought mobility to cloud computing. In this paper, we provide a reference base for the development of methodologies tailored for personal cloud computing. Besides, we also provide a security architecture for personal cloud based on the security requirement analysis.
Ligand Modulation of Lateral Segregation of a G-Protein-Coupled Receptor into Lipid Microdomains in Sphingo-myelin/Phosphatidylcholine Solid-Supported Bilayers (2006)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionLigand Modulation of Lateral Segregation of a G-Protein-Coupled Receptor into Lipid Microdomains in Sphingo-myelin/Phosphatidylcholine Solid-Supported BilayersIsabel D. Alves, Zdzislaw Salamon, Victor J. Hruby, and Gordon TollinCite this: Biochemistry 2006, 45, 12, 4044Publication Date (Web):March 7, 2006Publication History Published online7 March 2006Published inissue 1 March 2006https://pubs.acs.org/doi/10.1021/bi068005hhttps://doi.org/10.1021/bi068005hcorrectionACS PublicationsCopyright © 2006 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views219Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (6 KB) Get e-Alertsclose Get e-Alerts
Periprosthetic fractures associated with joint replacement (2014)

Come let us go down and confuse their language so they will not understand each other [1][1]

Fractures affecting long or flat bones, during or after joint replacement, are on the rise. An understanding of the mechanics and biology which should guide their treatment, as well as the potentially
2017 ELSA Open progress report (2017)

This report presents the progress achieved in 2017 in the implementation of the project for opening access to the ELSA Reaction Wall and HopLab facilities. Following the approval of the opening of access to JRC physical research infrastructures, the information regarding access to HopLab was collected, the evaluation criteria and associated weights were finalised, the dedicated pages in the JRC Science Hub were created, the calls for proposals were published and the User Selection Committees were established. Six proposals were submitted for access to ELSA HopLab, exceeding the planned availability of the facility within the project. The deadline for submission of proposals for access to ELSA Reaction Wall is the 31st of Janury 2018.
Monogenic Diabetes in the Young, Pharmacogenetics and Relevance to Multifactorial Forms of Type 2 Diabetes (2008)

Most valuable breakthroughs in the genetics of type 2 diabetes for the past two decades have arisen from candidate gene studies and familial linkage analysis of maturity-onset diabetes of the young (MODY), an autosomal dominant form of diabetes typically occurring before 25 years of age caused by primary insulin secretion defects. Despite its low prevalence, MODY is not a single entity but presents genetic, metabolic and clinical heterogeneity. MODY can result from mutations in at least six different genes encoding the glucose sensor enzyme glucokinase and transcription factors that participate in a regulatory network essential for adult beta-cell function. Additional genes have been described in other discrete phenotypes or syndromic forms of diabetes. Whereas common variants in the MODY genes contribute very modestly to type 2 diabetes susceptibility in adults, major findings emerging from the advent of genome-wide association studies will deliver an increasing number of genes and new pathways for the pathological events of the disease.
Site-specific Labeling of Antibody N-glycans using a Click Chemistry-mediated Chemoenzymatic Approach (2012)

We present here a modular click chemistry-mediated method for the site-specific enzymatic labeling of essentially any antibody on the heavy chain N-linked glycans. While standard antibody labeling techniques can be cumbersome and tedious, with variable reproducibility and low yields, the described approach results in highly reproducible labeling with built-in robustness. The site-selective approach prevents disruption of the antigen binding domain that often occurs with standard random amine or thiol labeling methods. This is especially important when labeling monoclonal antibodies with vulnerable amino acids in or around the antigen binding domain. Additionally, the modular “Lego-like” labeling system allows for the simple attachment of numerous detection molecules including fluorescent proteins, biotin, fluorescent dyes, and other small molecule compounds.
Functional Redundancy in HIV-1 Viral Particle Assembly (2012)

Expression of a retroviral Gag protein in mammalian cells leads to the assembly of virus particles. In vitro, recombinant Gag proteins are soluble but assemble into virus-like particles (VLPs) upon addition of nucleic acid. We have proposed that Gag undergoes a conformational change when it is at a high local concentration and that this change is an essential prerequisite for particle assembly; perhaps one way that this condition can be fulfilled is by the cooperative binding of Gag molecules to nucleic acid. We have now characterized the assembly in human cells of HIV-1 Gag molecules with a variety of defects, including (i) inability to bind to the plasma membrane, (ii) near-total inability of their capsid domains to engage in dimeric interaction, and (iii) drastically compromised ability to bind RNA. We find that Gag molecules with any one of these defects still retain some ability to assemble into roughly spherical objects with roughly correct radius of curvature. However, combination of any two of the defects completely destroys this capability. The results suggest that these three functions are somewhat redundant with respect to their contribution to particle assembly. We suggest that they are alternative mechanisms for the initial concentration of Gag molecules; under our experimental conditions, any two of the three is sufficient to lead to some semblance of correct assembly.