gebhart/patrepeval huggingface dataset:
Treatment of Schistosomal Myeloradiculopathy with Praziquantel and Corticosteroids and Evaluation by Magnetic Resonance Imaging: A Longitudinal Study (2004)

Treatment with praziquantel associated with corticosteroids was successful in all cases. MRI proved to be a good method for the diagnosis of SMR and helpful in the evaluation of response to treatment.
Improving latency tolerance of multithreading through decoupling (2001)

The increasing hardware complexity of dynamically scheduled superscalar processors may compromise the scalability of this organization to make an efficient use of future increases in transistor budget. SMT processors, designed over a superscalar core, are therefore directly concerned by this problem. The article presents and evaluates a novel processor microarchitecture which combines two paradigms: simultaneous multithreading and access/execute decoupling. Since its decoupled units issue instructions in order, this architecture is significantly less complex, in terms of critical path delays, than a centralized out-of-order design, and it is more effective for future growth in issue-width and clock speed. We investigate how both techniques complement each other. Since decoupling features an excellent memory latency hiding efficiency, the large amount of parallelism exploited by multithreading may be used to hide the latency of functional units and keep them fully utilized. The study shows that, by adding decoupling to a multithreaded architecture, fewer threads are needed to achieve maximum throughput. Therefore, in addition to the obvious hardware complexity reduction, it places lower demands on the memory system. The study also reveals that multithreading by itself exhibits little memory latency tolerance. Results suggest that most of the latency hiding effectiveness of SMT architectures comes from the dynamic scheduling. On the other hand, decoupling is very effective at hiding memory latency. An increase in the cache miss penalty from 1 to 32 cycles reduces the performance of a 4-context multithreaded decoupled processor by less than 2 percent. For the nondecoupled multithreaded processor, the loss of performance is about 23 percent.
Pteridophytes as active components in gardening, agricultural and horticultural ecosystems in Japan (2019)

Many members of Pteridophytes have been traditionally used in the designs of Japanese gardens and a large variety of ferns attract gardeners as greening pieces in the garden designs. However, details or examples of practical uses of ferns in traditional gardening in Japan have only rarely been introduced in non-Japanese literatures to date, despite the importance of ferns in Japanese gardening traditions. In addition to the discussion of ferns in gardening, the use and association of these plants in Japanese agricultural and horticultural sceneries are addressed. The presence and importance of 40 familiar fern species in local gardening, agricultural and horticultural ecosystems are also discussed, as well as the roles of introduced ferns as key elements of ecosystems and their interaction with neighboring biota. Finally, some examples of uses of fern species in environmental science and engineering are also reviewed.
Bounds on reachable sets using ordinary differential equations with linear programs embedded (2015)

This work considers the computation of rigorous componentwise time-varying bounds on the states of a non-linear control system. This work develops a new implementation of an existing bounding theory that exploits physical information to produce tight bounds. It is shown that the solution of a certain initial value problem in ordinary differential equations (ODEs) depending on parametric linear programs (LPs) (which are said to be ‘embedded’) yields componentwise bounds. To ensure the numerical tractability of such a formulation, some properties of the resulting system of ODEs with LPs embedded are discussed. Finally, the tightness of the bounds are demonstrated for models of reacting chemical systems with uncertain rate parameters.
Mechanical Characterization of Thin Films by the Capacitance-Voltage Measurement of Microstructures (2006)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Endocarditis infecciosa con compromiso bivalvular por Erysipelothrix rhusiopathiae (2023)

The microbiology of infective endocarditis (IE) varies in different populations and depends on public health conditions and socioeconomic status. In low-income countries, oral Streptococci affect hearts with rheumatic valve disease in patients with poor dentition. In high-income countries, Staphylococci are the most common cause, affecting elderly and immunocompromised patients, or those with invasive devices. Gram - positive bacili as IE pathogens are unusual. Erysipelothrix rhusiopathiae is a Gram positive bacili. It causes skin diseases in domestic and farm animals, but in humans, is a very unusual pathogen. This infection is considered a zoonosis, since most cases are linked to direct contact with vector animals. We report a 62 year-old male patient with a history of exposure to animals, who developed an infective endocarditis with severe bivalve regurgitation and septic shock, requiring antimicrobials and surgical resolution. Erysipelothrix rhusiopathiae was isolated from blood and valve vegetation cultures. The patient had a successful evolution and was discharged from the hospital.
Contractile Properties and the Force-Frequency Relationship of the Paralyzed Human Quadriceps Femoris Muscle (2006)

These findings may have important implications for designing stimulation strategies to reduce the rapid fatigue that limits the clinical efficacy of functional electrical stimulation.
Heparanase augments insulin receptor signaling in breast carcinoma (2016)

Recently, growing interest in the potential link between metabolic disorders (i.e., diabetes, obesity, metabolic syndrome) and breast cancer has mounted, including studies which indicate that diabetic/hyperinsulinemic women have a significantly higher risk of bearing breast tumors that are more aggressive and associated with higher death rates. Insulin signaling is regarded as a major contributor to this phenomenon; much less is known about the role of heparan sulfate-degrading enzyme heparanase in the link between metabolic disorders and cancer.In the present study we analyzed clinical samples of breast carcinoma derived from diabetic/non-diabetic patients, and investigated effects of heparanase on insulin signaling in breast carcinoma cell lines, as well as insulin-driven growth of breast tumor cells.We demonstrate that heparanase activity leads to enhanced insulin signaling and activation of downstream tumor-promoting pathways in breast carcinoma cells. In agreement, heparanase enhances insulin-induced proliferation of breast tumor cells in vitro. Moreover, analyzing clinical data from diabetic breast carcinoma patients, we found that concurrent presence of both diabetic state and heparanase in tumor tissue (as opposed to either condition alone) was associated with more aggressive phenotype of breast tumors in the patient cohort analyzed in our study (two-sided Fisher's exact test; p=0.04). Our findings highlight the emerging role of heparanase in powering effect of hyperinsulinemic state on breast tumorigenesis and imply that heparanase targeting, which is now under intensive development/clinical testing, could be particularly efficient in a growing fraction of breast carcinoma patients suffering from metabolic disorders.
A retrospective study on the incidence, management and risk factors of skin rash in patients with advanced prostate cancer in Japan (2023)

This study provides a better understanding of the real-world incidence, onset, duration, management and risk factors of skin rash in patients on active PC treatment in Japan. It was observed that approximately 20-30% of PC patients experience skin rash. Development of skin rash was associated with previous allergy or hypersensitivity, BMI of < 18.5, increased age and higher PSA levels, and was usually treated with corticosteroids.
Rapid detection of polyhydroxyalkanoate-accumulating bacteria isolated from the environment by colony PCR (2000)

Colony PCR and semi-nested PCR techniques were employed for screening polyhydroxyalkanoate (PHA) producers isolated from the environment. Three degenerate primers were designed based on multiple sequence alignment results and were used as PCR primers to detect PHA synthase genes. Optimized colony PCR conditions were achieved by adding 3% DMSO combined with 1 M betaine to the reaction mixture. The sensitivity limit of the colony PCR was 1x 10(5) viable cells for Ralstonia eutropha. Nineteen PHA-positive bacteria were used to evaluate this PCR protocol; fifteen of the nineteen could be detected by colony PCR, and the other four could be detected by applying semi-nested PCR detection following colony PCR. In a preliminary screening project, 38 PHA-positive strains were isolated from environmental samples by applying the PCR protocol, and their phenotype was further confirmed by Nile blue A staining assay. By combining the colony PCR and semi-nested PCR techniques, a rapid, reliable and highly accurate detection method has been developed for detecting PHA producers. This protocol is suitable for screening large numbers of environmental isolates. The PHA accumulation ability of well-separated colonies isolated from environmental samples can be directly validated by PCR with no further culturing or chromosomal DNA extraction procedures. In addition to its application to the screening of wild-type isolates, the individual PCR-amplified product is also suitable as a specific probe for PHA operon cloning. The results suggest that the application of this PCR protocol for rapid detection of PHA producers from the environment is plausible.
Influence of Soil Minerals on the Rates and Products of Abiotic Transformation of Carbon Tetrachloride in Anaerobic Soils and Sediments (2009)

Rates and products of abiotic mineral-mediated carbon tetrachloride (CT) transformation were measured in microcosms prepared from natural soils and sediments that were incubated under iron-reducing and sulfate-reducing conditions, then sterilized to inhibit microbial activity. For one set of microcosms, the rate of CT disappearance was correlated with the concentration of weakly bound (MgCl2 extractable) Fe(II) in an experiment in which CT was repeatedly spiked into the microcosms. When pooling the results from all microcosms, however, there was no statistically significant positive correlation between CT transformation rate and the concentration of weakly bound Fe(II) or any other mineral species. There was, however, a statistically significant negative correlation between CT transformation rate and the concentration of Cr(II) extractable sulfur (CrES). Evidence from X-ray photoelectron spectroscopy in a related model system containing a mixture of FeS and pyrite ("aged FeS") showed that the decline in CT disappearance rate corresponded to a decrease in the abundance of FeS and an increase in the abundance of pyrite at the mineral surface. For aged FeS, the yield of chloroform (CF) also decreased as the abundance of pyrite at the surface increased, and there was an inverse relationship between the yields of CF and CS2.
The majority of the activated T cells in the blood of insulin-dependent diabetes mellitus (IDDM) patients are CD4+. (1988)

Twenty-five recently diagnosed insulin-dependent diabetic patients were screened for the presence of activated T lymphocytes using the anti-IL-2 receptor monoclonal antibody; thirteen had elevated levels of activated T lymphocytes. The activated cells were mostly confined to the CD4 subset, with the CD4/CD8 ratio in IL-2 receptor expressing cells averaging 5 +/- 1 (s.d.) compared with 1.3 +/- 0.3 for all T cells. In recent onset insulin-dependent diabetes blood there was no lack of CD4 CD45R+ (suppressor/inducer) T cells. The activated IL-2 receptor, expressing cells belonged to both CD4 subsets, 'helper inducer' (CD44B4) and 'suppressor inducer', (CD42H4).
DNA Topoisomerase II Enzymes as Molecular Targets for Cancer Chemotherapy (2010)

DNA topoisomerase II enzymes regulate essential cellular processes by altering the topology of chromosomal DNA. These enzymes function by creating transient double-stranded breaks in the DNA molecule that allow the DNA strands to pass through each other and unwind or unknot tangled DNA. Because of the integral role of topoisomerases in regulating DNA metabolism, these enzymes are vital for cell survival. Several clinically active antitumor agents target these enzymes. Mammalian cells contain two topoisomerase II isozymes that are encoded by different genes: topoisomerase IIα and IIβ. Although, both isozymes are homologous and exhibit similar catalytic activity, they are differentially regulated and are involved in distinct biological functions. The topoisomerase IIα and topoisomerase IIβ enzymes are regulated by post-translational modifications, including sumoylation, ubiquitination and phosphorylation. These post-translational modifications influence the biologic and catalytic activity of the enzyme and affect sensitivity of cells to topoisomerase II-targeted drugs. In this review, we describe how the catalytic and biologic activity of the topoisomerase II enzyme is regulated and discuss the mechanisms by which chemotherapeutic agents that target these enzymes function. Given the potential importance of site-specific modifications, in particular phosphorylation, in regulating sensitivity to topoisomerase II-targeted drugs, we discuss the potential role of altered topoisomerase II phosphorylation in development of drug resistance, which is often a limiting factor in the treatment of cancer.
[Intensive care units: indications for admission and mortality]. (1988)

La moyenne d'âge est de 53 ans et 20% des personnes ont plus de 70 ans. Les admissions sont dues aux maladies suivantes: infarctus du myocarde 23%, arrythmies 17%, septicemie 9%, insuffisance respiratoire
Correction: MycN Is Critical for the Maintenance of Human Embryonic Stem Cell-Derived Neural Crest Stem Cells (2016)

The second author’s name is spelled incorrectly. The correct name is: Zhihui Weng. The correct citation is: Zhang JT, Weng Z, Tsang KS, Tsang LL, Chan HC, Jiang XH (2016) MycN Is Critical for the Maintenance of Human Embryonic Stem Cell-Derived Neural Crest Stem Cells. PLoS ONE 11(1): e0148062. doi:10.1371/journal.pone.0148062
Des robots hexapodes entièrement imprimés en 3D avec des articulations économes en énergie (2020)

National audience
Physical Activity and Gestational Diabetes Mellitus among Hispanic Women (2008)

Findings in this Hispanic population, although based on small numbers of cases, are consistent with prior research among predominantly non-Hispanic white populations.
An Empirical Comparison of Graph Databases (2013)

In recent years, more and more companies provide services that can not be anymore achieved efficiently using relational databases. As such, these companies are forced to use alternative database models such as XML databases, object-oriented databases, document-oriented databases and, more recently graph databases. Graph databases only exist for a few years. Although there have been some comparison attempts, they are mostly focused on certain aspects only. In this paper, we present a distributed graph database comparison framework and the results we obtained by comparing four important players in the graph databases market: Neo4j, Orient DB, Titan and DEX.
Nanoparticle Delivery Vehicles for Groundwater Remediation : Sustainability Evaluation through Biodegradation Studies (2012)

The use of biodegradable polymer coated iron nanoparticles for groundwater remediation is an emerging area of research. A polymer coating increases colloidal stability of the nanoparticles. The lack of biodegradation of the conventional polymers used to coat nanoparticles is a major concern, and limits the application of nanotechnology for groundwater remediation. The authors have synthesized a soybean oil based biodegradable amphiphilic copolymer that improves the colloidal stability of the nanoparticles in aqueous environment. A mixed culture of bacteria is used in biodegradation studies, and biochemical oxygen demand, total organic carbon, and reduction in molecular weight of the copolymer have been monitored over time. Microbial growth studies indicate that the microorganisms responsible for the degradation can survive on the copolymer as the only carbon source.
Effect of Stress Engineering on the Electrical Properties of BaTiO3 Thin Film (2011)

Nano porous LaNiO 3 (LNO) thin-film oxide electrodes were deposited on Si substrates by a chemical solution deposition (CSD) to control the residual stress in sputtered BaTiO 3 (BTO) thin film. The BTO thin film was deposited on the LNO/Si substrate by RF magnetron sputtering to elucidate the effect of the LNO thin-film electrode on the ferroelectric and dielectric properties of the resulting BTO thin film. The orientation of the LNO thin film was successfully controlled in the (100) direction even on the Si substrates, and therefore, the resulting BTO thin films also exhibited preferred orientation in the (001) direction. The BTO thin films deposited at a relatively low temperature of 500 °C exhibited a good hysteresis loop, indicating the usefulness of our CSD-derived LNO thin-film electrode. We also investigated the effect of the thickness of the LNO thin-film electrode on the ferroelectric property of the resulting BTO thin films.
Development of EUVL mask blank in AGC (2006)

Recent rapid progress in the technologies of extreme ultraviolet lithography (EUVL) is ensuring that EUVL will be a primary candidate for the next generation lithography beyond 32-nm node. However, realization of defect-free reflective mask blank is still counted as one of the most critical issues for high volume production in EUVL. Asahi Glass Company (AGC) has developed comprehensive technologies for manufacturing EUVL mask blanks from figuring and polishing glass substrate to cleaning, multilayer coating, and evaluating its performances by making use of our long and wide experience in providing high quality processed glass substrates and coatings for electronic devices. In this paper, we will present the current status of each aspect of EUVL mask blank development in AGC toward the specifications required for high volume production. In the effort to meet the specifications, we have introduced a number of key technologies that can be divided into three regions, which are materials, glass processings, and evaluations. We have developed state-of-the-art processes and tools for manufacturing EUV mask blanks, such as a new polishing technique for extremely flat substrate, a new cleaning recipe and tool for low-defect substrate, and a newly developed deposition tool for ultra-low defect and higher EUV reflective coating with our new optical thin film materials for multilayer coating. Furthermore, in order to clarify their performances, we also introduced a wide variety of evaluation techniques such as flatness and roughness measurement of substrate, a defect inspection, and EUV reflectometry as well as defect analysis techniques which help us eliminate printable defects in EUVL mask blanks.
Impaired lymphocyte stimulation by some streptococcal antigens in patients with recurrent aphthous stomatitis and rheumatic heart disease. (1970)

The effects of pathogenic and non-pathogenic streptococci, streptococcal cell wall products, and phytohaemagglutinin on human peripheral leucocyte cultures from four groups were studied. These groups were: (1) normals, (2) patients with aphthous stomatitis, (3) patients with Behçet's and (4) patients with rheumatic heart disease. The degree of lymphocyte stimulation by these materials was measured by uptake of [(3)H]thymidine into DNA in vitro. In normals, patients with aphthous stomatitis, and Behçet's disease, the human pathogenic group A streptococci produced significantly greater stimulation of DNA synthesis than did the less pathogenic non-haemolytic streptococci. Lymphocytes from patients with aphthous stomatitis showed significantly less stimulation of DNA synthesis than comparable normal controls when exposed to heat-killed Streptococcal 2A, organisms which have been implicated in the disease. Human pathogenic strains of group A streptococci which have been implicated in rheumatic heart disease stimulated significantly less in vitro proliferation of lymphocytes from patients with rheumatic heart disease than of those from a comparable group of normal controls. This hypo-responsiveness persisted when the patients' lymphocytes were cultured in normal human serum. The chronically ill Behçet's patients' lymphocytes did not differ significantly from normal. These observations indicate a deficiency of the cellular response of certain patients to antigens from organisms thought to be aetiologically related to their disease.
Mechanical characteristics of three staples commonly used in foot surgery (2009)

The Richards staple was stiffer, although the permanent deformation of this staple is a disadvantage. Memoclip staples exhibit lower but adequate stiffnesss when compared to the standard Richards staple and are not permanently deformed after bending. The Memoclip staples were easier to handle. The results will enable surgeons to determine the optimal staple for foot and ankle procedures.
Photooxidation of hexamethylbenzene and related aromatic systems (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotooxidation of hexamethylbenzene and related aromatic systemsHarry H. Wasserman, Patrick S. Mariano, and Philip M. KeehnCite this: J. Org. Chem. 1971, 36, 13, 1765–1769Publication Date (Print):July 1, 1971Publication History Published online1 May 2002Published inissue 1 July 1971https://doi.org/10.1021/jo00812a009Request reuse permissionsArticle Views155Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (651 KB) Get e-Alertsclose Get e-Alerts