gebhart/patrepeval huggingface dataset:
Effect of IL-7 or IL-4 on reconstitution of donor lymphoid cells in congenic murine bone marrow transplantation. (1995)

IL-7 and IL-4 are known to influence the growth of cells of the lymphoid lineage. In this study, we investigated the effects of in vivo administration of IL-7 or IL-4 in mice subjected to congenic BM transplant. C57BL/6 Ly5.1+ mice were subjected to TBI, followed by transfer of B and T cell-depleted BM from C57BL/6 Ly5.2+ donor mice. Recipient mice were implanted with 14-day miniosmotic pumps that delivered IL-7, IL-4 or PBS and were examined for reconstitution of lymphoid cells using flow cytometry on different days. We observed no significant difference in the number of splenocytes, thymocytes and PBLs between recipient mice administered with cytokines or normal control mice. However, we observed that IL-4 infusion resulted in appearance of increased numbers of donor CD23+B220+ cells and also donor cells expressing Fc receptors for IgM (Fc micro R) and B220. Since CD23 is present only on mature B cells, our data demonstrate that following BMT, IL-4 treatment results in the development of more mature B cells compared to control mice. Additionally, we observed that IL-7 infusion resulted in significantly decreased expression of donor sIgM+B220+ cells. However, the effects of IL-7 or IL-4 were observed when the cytokines were actively administered and rapidly abated upon cessation of cytokine therapy.
A control system for automated multi-purpose vehicles for manufacturing applications (2008)

This paper presents a system to control Autonomously Guided Vehicles (AGVs) in a flexible manufacturing setting allowing numerous vehicles to make informed decisions amongst themselves as well as between the governing computer system(s). These decisions allow work order acceptance, path planning, navigation, and traffic management to be autonomously operated - rather than pre-programmed as are the traditional methods. This paper is mostly focused on the work order acceptance protocols, as this is the area which is of most benefit to a flexible manufacturing system. Some work on autonomous path planning is also involved, but since a guided system is still being used, this logic is limited to pre-set paths only. Such autonomy of the entire system would benefit a manufacturing setting by allowing the vehicles to be flexible in their work and ready upon command for whatever job the user requests. The vehicles are modeled using the Lego NXT Mindstorm kits to demonstrate the functionality of the communication protocols created through this paper.
PARTITIONING OF ALLOYING ELEMENTS IN A NICKEL BASE SUPERALLOY CONTAINING Nb AND Mo : AN ATOM-PROBE STUDY (1984)

A time of flight atom-probe is used for determining phase composition in a nickel base superalloy and a tentative derivation of preferential sites occupied by solute elements in the ordered γ' phase is made.
UV‐Vis‐spektroskopische Eigenschaften 3,5‐disubstituierter 1,3,4‐Oxadiazolin‐2‐imine. I. Einfluß der Substituenten und des Lösungsmittels auf die Absorption (1981)

The U.V.‐vis‐spectroscopic Properties of 3,5‐disubstituted 1,3,4‐Oxadiazoline‐2‐imines. I. The Influence of the Substituents and the Solvent on the Absorption The u.v.‐vis data of 38 derivatives of 3,5‐disubstituted 1,3,4‐oxadiazoline‐2‐imines, measured in 12 different solvents, are discussed. The long wave absorption bands have charge‐transfer character, the observed solvatochromic shifts correlate with the solvent parameter E T . The assumed intramolecular charge‐transfer upon excitation is polarized in the direction R 1 N 3 C 5 R 2 . Derivatives which are donor‐substituted in the 3‐position of the oxadiazolinimine cycle (R 1 ) and acceptor‐substituted in the 5‐position (R 2 ) show a typical push‐pull effect. In this case bathochromic and hyperchromic effects on the long‐wave absorption bands result. On the other hand, R 1 is a donor and R 2 is an acceptor substituent the excitation energy is increasing.
Synthesis of maleic and fumaric acids from furfural in the presence of betaine and hydrogen peroxide (2017)

International audience
Human Immunodeficiency Virus Protease Inhibitors Serve as Substrates for Multidrug Transporter Proteins MDR1 and MRP1 but Retain Antiviral Efficacy in Cell Lines Expressing These Transporters (1998)

The human immunodeficiency virus type 1 (HIV-1) protease inhibitors (PIs)-saquinavir, ritonavir, nelfinavir, and indinavir-interact with the ABC-type multidrug transporter proteins MDR1 and MRP1 in CEM T-lymphocytic cell lines. Calcein fluorescence was significantly enhanced in MDR1(+) CEM/VBL100 and MRP1(+) CEM/VM-1-5 cells incubated in the presence of various HIV PIs and calcein acetoxymethyl ester. HIV PIs also enhanced the cytotoxic activity of doxorubicin, a known substrate for MDR1 and MRP1, in both VBL100 and VM-1-5 CEM lines. Saquinavir, ritonavir, and nelfinavir enhanced doxorubicin toxicity in CEM/VBL100 cells by approximately three- to sevenfold. Saquinavir and ritonavir also enhanced doxorubicin toxicity in CEM/VM-1-5 cells. HIV-1 replication was effectively inhibited by the various PIs in all of the cell lines, and the 90% inhibitory concentration for a given compound was comparable between the different cell types. Therefore, overexpression of MDR1 or MRP1 by T lymphocytes is not likely to limit the antiviral efficacy of HIV PI therapy.
3‐D high resolution Radon transforms applied to ground roll suppression in orthogonal seismic surveys (2004)

Backscattered ground roll that leaks through the shot and group arrays has long been a problem in land seismic acquisition. Since ground roll is usually aliased, linear filtering techniques applied to common midpoint, common shot, or common receiver gathers based on f‐k or linear tau‐p filtering often fail. Motivated by a desire to extend concepts of 3‐D beam migration to 3‐D land surveys, we have developed f‐x‐y domain least squares Radon transform and a new time domain 3‐D high resolution Radon transform that uses a coherence measure to determine whether or not a given plane wave component is aliased. While the time domain nonlinear tau‐p‐q is expensive, the added cost allows us to implement it in a more efficient and more robust migration algorithm.
Statistische Untersuchungen zur Strukturkomplementarität von Naturstoffen und synthetischen Substanzen (1999)

Noch lange nicht erschöpft ist das Potential an neuen Naturstoffen als bedeutende Quelle für die Erforschung und Entwicklung neuer Arzneimittel sowie Pflanzenschutzprodukte. Wie aus statistischen Analysen der Strukturen natürlicher und synthetischer Verbindungen hervorgeht, ist die Strukturvarianz von Naturstoffen aus unterschiedlichen natürlichen Quellen auffällig und kann bei der Wirkstoffsuche individuell berücksichtigt werden. Das gelegentlich formulierte Vorurteil, Naturstoffe seien bereits breit untersucht und folglich seien keine Neuerungen mehr zu erwarten, läßt sich damit eindeutig entkräften.
Role of Protein Kinase C (PKC) in Short- and Long-Term Cellular Responses (1988)

Active tumor promoters such as 12-O-tetradecanoyl-phorbol-13-acetate (TPA) or membrane-diffusible synthetic diacylglycerols such as 1,2-dioctanoyl-sn-glycerol (DiC8), which specifically activate protein kinase C (PKC), inhibited the agonist-mediated rise in cytosolic calcium [(Ca2+)i] in a mast cell line (PB-3c) and human platelets. TPA inhibition of agonist-mediated calcium transient in platelets was readily reversed by the PKC inhibitor staurosporine. In contrast to DiCs, only active tumor promoters induced a time- and dose-dependent translocation of cytosolic PKC to membranes as determined both enzymatically or by immunoblotting. However, the concentration of TPA required to induce a half-maximal subcellular redistribution of immunodetectable PKC activity was an order of magnitude greater than the half-maximal dose required to inhibit the intracellular rise in (Ca2+)i. Thus, activation of PKC seems not to be exclusively coupled to its translocation to membranes, suggesting that translocation of PKC is mainly involved in the down-regulation of PKC. Down-regulation of immunoprecipitable PKC was studied in various human breast cancer cell lines that display differential growth inhibitory responses toward the tumor promoter. TPA induced translocation of [35S]methionine-prelabeled cytosolic 80 kDa PKC to membranes followed by complete degradation of the enzyme (t1/2 = 2 h) without affecting PKC synthesis. During prolonged TPA exposure, 20-80% of total 80 kDa PKC of control cells was still synthetized as a membrane-bound 74/80 kDa PKC doublet. Although both proteins lacked PKC activity and phorbol ester binding, they revealed structural similarity with the active 80 kDa PKC form of untreated cells.(ABSTRACT TRUNCATED AT 250 WORDS)
The Development of an Highly Modular Designed Zero-Dimensional Engine Process Calculation Code (2010)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;The main objective of the FVV-project “Cylinder Module” was the development of a profoundly modular designed concept for object-oriented modeling of in-cylinder processes of internal combustion engines. It was designed in such a way, that it can either be used as a stand-alone real working-process calculation tool or in tools for whole vehicle simulations. It is possible to run the “Cylinder Module”-code inside the FVV-“GPA”-software for transient vehicle and driving cycle simulations and it is possible to use the graphical user interface “ATMOS” of the “GPA”-project. The code can also be used as a user-subroutine in 1-D-flow simulation codes. Much effort was spent on the requirements of flexibility and expandability in order to be well prepared to cope with the diversity of both today's and future tasks. The code is freely available for members of the German Research Association for Combustion Engines (FVV).&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;In the working-process calculation an analytical solution for the calculation of the difference quotients was developed, which is suitable for a user-defined number of zones in every thermodynamical system, too. As a consequence, exactly the same source code can be used for one-, two- or multi-zone calculations. In fact, additional zones can be switched on simply in case of need. It is possible to simulate a user-defined number of connected thermodynamical systems contemporaneously.&lt;/div&gt;&lt;/div&gt;
Osterix Regulates Tooth Root Formation in a Site-specific Manner (2015)

Bone and dentin share similar biochemical compositions and physiological properties. Dentin, a major tooth component, is formed by odontoblasts; in contrast, bone is produced by osteoblasts. Osterix (Osx), a zinc finger-containing transcription factor, has been identified as an essential regulator of osteoblast differentiation and bone formation. However, it has been difficult to establish whether Osx functions in odontoblast differentiation and dentin formation. To understand the role of Osx in dentin formation, we analyzed mice in which Osx was subjected to tissue-specific ablation under the control of either the Col1a1 or the OC promoter. Two independent Osx conditional knockout mice exhibited similar molar abnormalities. Although no phenotype was found in the crowns of these teeth, both mutant lines exhibited short molar roots due to impaired root elongation. Furthermore, the interradicular dentin in these mice showed severe hypoplastic features, which were likely caused by disruptions in odontoblast differentiation and dentin formation. These phenotypes were closely related to the temporospatial expression pattern of Osx during tooth development. These findings indicate that Osx is required for root formation by regulating odontoblast differentiation, maturation, and root elongation. Cumulatively, our data strongly indicate that Osx is a site-specific regulator in tooth root formation.
The dependence of WAAS ionospheric error bounds upon the spatial distribution of GPS measurements (2003)

This paper examines the dependence of the threat model upon the spatial distribution of GPS measurements.
The singular value decomposition for polynomial systems (1995)

This paper introduces singular value decomposition (SVD) algorithms for some standard polynomial computations, in the case where the coefficients are inexact or imperfectly known. We first give an algorithm for computing univariate GCD's which gives exact results for interesting nearby problems, and give efficient algorithms for computing precisely how nearby. We generalize this to multivariate GCD computation. Next, we adapt Lazard's u-resultant algorithm for the solution of overdetermined systems of polynomial equations to the inexact-coefficient case. We also briefly discuss an application of the modified Lazard's method to the location of singular points on approximately known projections of algebraic curves.
Uranium mill tailings remedial action program. Radiological survey of Shiprock vicinity property SH03, Shiprock, NM, July-November 1982 (1984)

A comprehensive survey of the vicinity property designated as SH03 was conducted on an intermittent basis from July 26 to November 11, 1982. At the time of the survey, three structures were located on the property - a residential trailer, the main structure, and an old gas pump housing. The lands surrounding the structures were either sparsely covered with arid vegetation or paved. The assessment activities included determination of indoor and outdoor surface radiation levels, for both fixed and removable contamination, through direct instrument and smear (indoor only) surveys; measurement of ambient external penetrating radiation levels at 1-meter heights; and analyses of air, soil, and other material samples. No evidence of radioactive contamination was found inside the trailer. However, the results of the radiological assessment did indicate the occurrence of elevated levels of gamma, surface alpha, and radon daughter radioactivity within the main structure. The short-term radon daughter measurements exceeded the limit of 0.02 Working Level for average annual concentration including background. The assessment also indicated elevated levels of radioactivity in the outdoor environs, encompassing about 32,000 ft/sup 2/ of the grounds adjacent to and surrounding the main structure on the east, south, and west sides. The contamination appeared to be due to the presence of unprocessed uranium ore. Analysis of surface soil samples collected from the environs indicated radium concentrations in excess of the limit of 5 pCi/g above background specified in the EPA Standard. Subsurface soil sampling was not conducted, and thus the vertical extent of the radiological contamination is not known. Since the surface soil contamination levels exceeded the limits specified in the EPA Standard, remedial action for this vicinity site should be considered.
Reductive elimination of epoxides to olefins with zinc-copper couple (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReductive elimination of epoxides to olefins with zinc-copper coupleS. Morris Kupchan and Masao MaruyamaCite this: J. Org. Chem. 1971, 36, 9, 1187–1191Publication Date (Print):May 1, 1971Publication History Published online1 May 2002Published inissue 1 May 1971https://pubs.acs.org/doi/10.1021/jo00808a005https://doi.org/10.1021/jo00808a005research-articleACS PublicationsRequest reuse permissionsArticle Views558Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Electromigration of C4 Bumps in Ceramic and Organic Flip-Chip Packages (2006)

As technology continues to scale, there is increasing demands on I/O counts and power requirements, leading to decreasing solder pitch and increasing current density for solder bumps in high-density flip-chip packages. At the same time, increasing performance requirements has led to the use of organic packages instead of the conventional ceramic packages. Hence it is very important to be able to measure the current carrying capability of solder bumps and evaluate the impact of reduced bump pitch and use of organic packages on EM reliability. In this paper, we run conventional EM test configuration using mechanically shorted dies and making the connection to the solder bumps through the flip-chip package directly mounted on the test boards to evaluate the effect of varying bump pitches on the electromigration performance of the solder bumps. Our results show that electromigration resistance is very high on ceramic packages with high lead solders and degrades significantly when high lead solder is used in conjunction with eutectic solder on organic packages.
Allergic lung inflammation alters neither susceptibility to Streptococcus pneumoniae infection nor inducibility of innate resistance in mice (2009)

These results suggest that allergic airway inflammation neither promotes nor inhibits progression of pneumococcal lung infection in mice, nor does it influence the successful induction of stimulated innate resistance to bacteria.
Inpatient multidisciplinary care can prevent deterioration of renal function in patients with chronic kidney disease: a nationwide cohort study (2023)

Multidisciplinary care may significantly slow deterioration of eGFR and reduce proteinuria in patients with CKD and be more effective in terms of reducing initiation of RRT and all-cause mortality when provided on an inpatient basis.
Metrics and methods in the evaluation of prestige bias in peer review: A case study in computer systems conferences (2022)

The integrity of peer review is essential for modern science. Numerous studies have therefore focused on identifying, quantifying, and mitigating biases in peer review. One of these better-known biases is prestige bias, where the recognition of a famous author or affiliation leads reviewers to subconsciously treat their submissions preferentially. A common mitigation approach for prestige bias is double-blind reviewing, where the identify of authors is hidden from reviewers. However, studies on the effectivness of this mitigation are mixed and are rarely directly comparable to each other, leading to difficulty in generalization of their results. In this paper, we explore the design space for such studies in an attempt to reach common ground. Using an observational approach with a large dataset of peer-reviewed papers in computer systems, we systematically evaluate the effects of different prestige metrics, aggregation methods, control variables, and outlier treatments. We show that depending on these choices, the data can lead to contradictory conclusions with high statistical significance. For example, authors with higher h-index often preferred to publish in competitive conferences which are also typically double-blind, whereas authors with higher paper counts often preferred the single-blind conferences. The main practical implication of our analyses is that a narrow evaluation may lead to unreliable results. A thorough evaluation of prestige bias requires a careful inventory of assumptions, metrics, and methodology, often requiring a more detailed sensitivity analysis than is normally undertaken. Importantly, two of the most commonly used metrics for prestige evaluation, past publication count and h-index, are not independent from the choice of publishing venue, which must be accounted for when comparing authors prestige across conferences.
Insulin Resistance, Hyperinsulinemia, Hypertriglyceridemia, and Hypertension: Parallels Between Human Disease and Rodent Models (1991)

There is considerable evidence that abnormalities of glucose, insulin, and lipoprotein metabolism occur more frequently in untreated hypertensive patients than in normotensive control subjects. More recently, it has also become apparent that similar metabolic abnormalities occur in rodent models of hypertension. One purpose of this article is to review the experimental data that have led to the above generalizations. The second goal is to address the significance of these findings, which is certainly not clear. For example, it could be argued that the relationship between high blood pressure and the associated metabolic defects is incidental. On the other hand, there is evidence that the changes in glucose, insulin, and lipoprotein metabolism may play a role in the etiology and/or clinical course of patients with high blood pressure. Although it is impossible at this point to definitively choose between these possibilities, an effort is made to marshal the evidence in support of the latter alternative.
Synthesis of Enol Esters and Dimerization of Terminal Alkynes Catalyzed by Neutral and Cationic Vinylidene Ruthenium Complexes (2003)

In the current study Ru(II) vinylidene complexes of the general type: Cl2Ru{=C=C(H)R}(PR′3)L (R = Ph, SiMe3, R′ = Ph, Cyclohexyl (Cy) and L = phosphine or N-heterocyclic carbene) are synthesized and tested for the addition of carboxylic acids to terminal alkynes. A careful choice of the catalytic system, substrate and carboxylic acid gives access to alk-1-en-2-yl esters, alk-1-en-1-yl esters or enyne dimerization products.
Statistically robust cognitive radio beamforming (2013)

We consider a cognitive radio (CR) network consisting of a secondary user transmitter (SU-Tx) equipped with multiple antennas and a secondary user receiver (SU-Rx) that share spectrum with multiple primary user transmitter (PU-Tx) and receiver (PU-Rx) pairs. We assume that the CR has a loose cooperation with the primary network and therefore, only partial channel state information of each of the PU-Tx to PU-Rx and SU-Tx to each PU-Rx links is available. Furthermore, we assume that the SU-Tx to SU-Rx link CSI is imperfect, with the channel error modelled as additive Gaussian noise. Under these assumptions, we propose a new statistically robust CR beamformer where the total SU-Tx transmit power is minimised subject to PU-Rx and SU-Rx outage probability constraints. We present expressions for PU-Rx and SU-Rx outage probabilities and formulate the robust beamformer optimisation problem as a convex semidefinite program (SDP). SU-Tx transmit power, PU-Rx signal-to-interference-and-noise ratio (SINR) and SU-Rx signal-to-noise (SNR) cumulative distribution functions (CDFs) are obtained through solution of our optimisation problem.
Injectable Nonsteroidal Anti-Inflammatory Drugs in Sport (2018)

Nonsteroidal anti-inflammatory drug medications are currently used at every level of competition. Injectable ketorolac is an effective analgesic and anti-inflammatory drug. However, its potential effectiveness must be weighed against the risk of potential complications in all athletes, especially those who participate in contact/collision sports. The team physician must balance the goal of treating pain and inflammation with the ethical implications and medical considerations inherent in the administration of injectable medications solely to prevent pain and/or return the athlete to competition.
2-(2-Benzoylethynyl)-5-phenylpyrrole: fixation of cis- and trans-rotamers in a crystal state (2005)

2-(2-Benzoylethynyl)-5-phenylpyrrole forms two crystal modifications with the carbonyl group oriented in cis- and trans-positions relative to the nitrogen atom thus representing the first example of the solid state stable rotamers around the CC bond system.