gebhart/patrepeval huggingface dataset:
Bilayer for extending the wavelength of QD lasers (2010)

This paper reports on the analysis of MBE grown bilayer quantum dot (QD) laser material. Specifically, gain and absorption characteristics of 5x 'single' QD layers with InGaAs caps, 5x 'bilayer' QDs with GaAs caps and 5x 'bilayer' QDs with InGaAs cap layers are compared. For an In0.18Ga0.82As capped bilayer sample at room temperature, net modal gain is demonstrated beyond 1500 nm.
ELECTRICAL CONDUCTIVITY OF DOPED POLYACRYLONITRILE (PAN) (1983)

The electrical conductivity and optical absorption spectra of halogen doped PAN have been investigated. When films of PAN previously heated in vacuum to 280°C are exposed to bromine or iodine vapor the conductivity rises suddenly. The conductivity is reduced by pumping off the vapor, but upon subsequent reheating the conductivity increases dramatically, with a transition occurring at about 270°C. Undoped samples were previously reported to undergo a similar transition above 390°C. All samples obey σ ∝ T-1/4 behavior, suggesting 3-dimensional variable range hopping as the conduction mechanism. The optical and infrared absorption spectra of doped PAN are compared to those previously reported for the undoped material. The stability of doped PAN in air is also discussed.
Novel Wideband Transition Between Coplanar Waveguide and Microstrip Line (2010)

A novel wideband vertical transition for connecting the coplanar waveguide (CPW) to the microstrip line is proposed. This transition can be very useful for millimeter-wave packaging and vertical interconnects. It is multilayered, partly tapered, and consists of only one via interconnect. Two different transitions are designed. The first transition allows connectivity of a CPW with <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$Z_{c}=50\ \Omega$</tex></formula> to a microstrip line with <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$Z_{c}=16\ \Omega$</tex></formula> with a bandwidth of 10–60 GHz. The second transition has the same characteristic impedance, <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$Z_{c}=50\ \Omega$</tex></formula> , at the two ports. In this case, the operating frequency is from 40 MHz to 60 GHz. The return losses of both transitions are generally lower than <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex Notation="TeX">$-$</tex></formula> 10 dB over their indicated frequency ranges, while the maximum measured insertion losses are 1.8 and 2.4 dB for the first and second transition, respectively. To extract the <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex Notation="TeX">$S$</tex></formula> -parameters of the transitions, a new thru-line technique, based on the standard thru-reflect-line two-tier calibration is introduced. Simulation and experimental results, showing good agreement, are presented and discussed.
Design better cerium-based oxidation catalysts (1997)

Structural and energetic factors play an important role in the development of a new generation of automobile exhaust catalysts containing CeO{sub 2} doped with ZrO{sub 2} and/or other rare earth oxides such as PrO{sub x}, Y{sub 2}O{sub 3}, and La{sub 2}O{sub 3}. These new catalysts possess high oxygen storage capacity, improved thermal stability, and enhanced catalytic properties. These properties are discussed.
Force feedback slider (FFS): interactive device for learning system dynamics (2005)

Physics education often relies on visualization of theoretical laws. While Java animations are widespread, they mostly lack user interaction. We propose a haptic device inviting users to interact with the law of physics. Based on an in-house design - a generic force feedback slider (FFS) - we have realized a software application simulating a catapult. As users interact, they receive both tactile and visual feedback. By calling upon two perceptual channels at a time, here tactile and visual, we assume users may construct their mental model more easily. This paper presents our application, the underlying FFS technology, a user study, future uses, and a discussion.
Epigenetic regulation of the circadian clock: role of 5-aza-2′-deoxycytidine (2017)

We have been investigating transcriptional regulation of the <i>BMAL1</i> gene, a critical component of the mammalian clock system including DNA methylation. Here, a more detailed analysis of the regulation of DNA methylation of <i>BMAL1</i> proceeded in RPMI8402 lymphoma cells. We found that CpG islands in the <i>BMAL1</i> and the <i>PER2</i> promoters were hyper- and hypomethylated, respectively and that 5-aza-2'-deoxycytidine (aza-dC) not only enhanced <i>PER2</i> gene expression but also <i>PER2</i> oscillation within 24 h in RPMI8402 cells. That is, such hypermethylation of CpG islands in the <i>BMAL1</i> promoter restricted <i>PER2</i> expression which was recovered by aza-dC within 1 day in these cells. These results suggest that the circadian clock system can be recovered through <i>BMAL1</i> expression induced by aza-dC within a day. The <i>RPIB9</i> promoter of RPMI8402 cells, which is a methylation hotspot in lymphoblastic leukemia, was also hypermethylated and aza-dC gradually recovered <i>RPIB9</i> expression in 3 days. In addition, methylation-specific PCR revealed a different degree of aza-dC-induced methylation release between <i>BMAL1</i> and <i>RPIB9</i> These results suggest that the aza-dC-induced recovery of gene expression from DNA methylation is dependent on a gene, for example the rapid response to demethylation by the circadian system, and thus, is of importance to clinical strategies for treating cancer.
Cholangiocyte Myosin IIB Is Required for Localized Aggregation of Sodium Glucose Cotransporter 1 to Sites ofCryptosporidium parvumCellular Invasion and Facilitates Parasite Internalization (2010)

Internalization of the obligate intracellular apicomplexan parasite, Cryptosporidium parvum, results in the formation of a unique intramembranous yet extracytoplasmic niche on the apical surfaces of host epithelial cells, a process that depends on host cell membrane extension. We previously demonstrated that efficient C. parvum invasion of biliary epithelial cells (cholangiocytes) requires host cell actin polymerization and localized membrane translocation/insertion of Na(+)/glucose cotransporter 1 (SGLT1) and of aquaporin 1 (Aqp1), a water channel, at the attachment site. The resultant localized water influx facilitates parasite cellular invasion by promoting host-cell membrane protrusion. However, the molecular mechanisms by which C. parvum induces membrane translocation/insertion of SGLT1/Aqp1 are obscure. We report here that cultured human cholangiocytes express several nonmuscle myosins, including myosins IIA and IIB. Moreover, C. parvum infection of cultured cholangiocytes results in the localized selective aggregation of myosin IIB but not myosin IIA at the region of parasite attachment, as assessed by dual-label immunofluorescence confocal microscopy. Concordantly, treatment of cells with the myosin light chain kinase inhibitor ML-7 or the myosin II-specific inhibitor blebbistatin or selective RNA-mediated repression of myosin IIB significantly inhibits (P < 0.05) C. parvum cellular invasion (by 60 to 80%). Furthermore ML-7 and blebbistatin significantly decrease (P < 0.02) C. parvum-induced accumulation of SGLT1 at infection sites (by approximately 80%). Thus, localized actomyosin-dependent membrane translocation of transporters/channels initiated by C. parvum is essential for membrane extension and parasite internalization, a phenomenon that may also be relevant to the mechanisms of cell membrane protrusion in general.
Monoclonal antibodies that specifically recognize neoepitope sequences generated by ‘aggrecanase’ and matrix metalloproteinase cleavage of aggrecan: application to catabolism in situ and in vitro (1995)

Monoclonal antibodies have been prepared that react specifically with the neoepitopes present on proteoglycan degradation products generated from the proteolytic cleavage of aggrecan in the interglobular domain. Antibody BC-3 recognizes the new N-terminus (ARGSV...) on aggrecan degradation products produced by the action of the as yet uncharacterized proteolytic activity, 'aggrecanase', and antibody BC-4 recognizes the new C-terminus (...DIPEN) generated by the proteolytic action of matrix metalloproteinases. Specificity for these neoepitope sequences was determined in competitive e.l.i.s.a. using synthetic peptide antigens as inhibitors. Antibody BC-3 was used in the detection of aggrecan degradation products in the culture medium obtained from two different in vitro culture systems: bovine cartilage explants treated with either retinoic acid or interleukin-1, and secondly, rat chondrosarcoma cells treated with retinoic acid. Both interleukin-1 and retinoic acid treatment caused an increase in aggrecan catabolism resulting in an increased release to the medium of specific aggrecan degradation products containing the BC-3 neoepitope generated by the action of 'aggrecanase'. However, several additional aggrecan catabolites were present that were not immunoreactive with antibody BC-3. In addition, under control conditions, in the bovine cartilage cultures the BC-3 epitope was found on some of these aggrecan catabolites. In contrast, no immune-reactive material was found in the aggrecan degradation products present in control media of rat chondrosarcoma cells cultured in the absence of retinoic acid. Collectively, these results demonstrate that 'aggrecanase' activity is not a constitutive event in all cartilage culture systems and also suggest that proteolytic agents other than 'aggrecanase' are involved in aggrecan catabolism in normal turnover compared with pathological conditions. Antibody BC-4 was used to demonstrate the identity of the G1 domain of aggrecan following proteolytic cleavage of a purified G1-G2 preparation with collagenase, gelatinase A or stromelysin. The G2 product of this cleavage did not react with antibody BC-3, indicating that, under the experimental conditions used, none of these enzymes exhibited 'aggrecanase' activity. It is expected that both of these antibodies will play a pivotal role in detailed studies elucidating molecular mechanisms of aggrecan degradation and they will be particularly useful for the sensitive monitoring of aggrecan degradation products in tissue extracts and body fluids.
668: Pre Radiation PSA Predicts for Outcome of Adjuvant Radiation in SWOG 8794 (2006)

You have accessJournal of UrologyDiscussed Poster, Monday, May 22, 2006, 9:00 am - 12:00 pm1 Apr 2006668: Pre Radiation PSA Predicts for Outcome of Adjuvant Radiation in SWOG 8794 Gregory P. Swanson, Michael A. Hussey, Ian M. Thompson, and E. David Crawford Gregory P. SwansonGregory P. Swanson More articles by this author , Michael A. HusseyMichael A. Hussey More articles by this author , Ian M. ThompsonIan M. Thompson More articles by this author , and E. David CrawfordE. David Crawford More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)32914-8AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "668: Pre Radiation PSA Predicts for Outcome of Adjuvant Radiation in SWOG 8794." The Journal of Urology, 175(4S), p. 216 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 175Issue 4SApril 2006Page: 216 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Gregory P. Swanson More articles by this author Michael A. Hussey More articles by this author Ian M. Thompson More articles by this author E. David Crawford More articles by this author Expand All Advertisement PDF downloadLoading ...
A novel scalable, robust downstream process for oncolytic rat parvovirus: isoelectric point-based elimination of empty particles (2017)

The rodent protoparvovirus H-1PV, with its oncolytic and oncosuppressive properties, is a promising anticancer agent currently under testing in clinical trials. This explains the current demand for a scalable, good manufacturing practice-compatible virus purification process yielding high-grade pure infectious particles and overcoming the limitations of the current system based on density gradient centrifugation. We describe here a scalable process offering high purity and recovery. Taking advantage of the isoelectric point difference between full and empty particles, it eliminates most empty particles. Full particles have a significantly higher cationic charge than empty ones, with an isoelectric point of 5.8-6.2 versus 6.3 (as determined by isoelectric focusing and chromatofocusing). Thanks to this difference, infectious full particles can be separated from empty particles and most protein impurities by Convective interaction media<sup>®</sup> diethylaminoethyl (DEAE) anion exchange chromatography: applying unpurified H-1PV to the column in 0.15 M NaCl leaves, the former on the column and the latter in the flow through. The full particles are then recovered by elution with 0.25 M NaCl. The whole large-scale purification process involves filtration, single-step DEAE anion exchange chromatography, buffer exchange by cross-flow filtration, and final formulation in Visipaque/Ringer solution. It results in 98% contaminating protein removal and 96% empty particle elimination. The final infectious particle concentration reaches 3.5E10 plaque forming units (PFU)/ml, with a specific activity of 6.8E11 PFU/mg protein. Overall recovery is over 40%. The newly established method is suitable for use in commercial production.
Sara Pérez Fuentes (2013)

Sara Perez Fuentes es Ayudante de Investigacion en el Departamento Produccion y Sanidad Animal, Salud Publica Veterinaria y Ciencia y Tecnologia de los Alimentos, en la Universidad CEU Cardenal Herrera
Hepatoid Carcinoma of the Pancreas: Case Report, Next-Generation Tumor Profiling, and Literature Review (2016)

Fewer than 25 cases of hepatoid carcinoma of the pancreas have been reported in the literature. We present a case in a 61-year-old male with a remote history of Hodgkin's lymphoma and gastric neuroendocrine cell hyperplasia. On surveillance endoscopic ultrasound, an 8 × 5 mm cystic lesion was seen in the tail of the pancreas. MRI showed a focal pancreatic duct cut-off with mild ductal dilation. Fine needle aspiration was performed, which was concerning for acinar cell carcinoma. The patient underwent distal pancreatectomy and recovered uneventfully. Final pathology demonstrated a 1.3-cm hepatoid carcinoma of the pancreas, with a final clinicopathological stage of T1N0M0. Next-generation nucleic acid sequencing of the tumor did not suggest a viable adjuvant chemotherapeutic agent, and no adjuvant therapy was administered. The patient has no evidence of disease 6 months following resection. A further characterization and description of the outcomes of these rare tumors is warranted to help guide providers and counsel patients.
Association Studies of Insulin Receptor Substrate 1 Gene (IRS1) Variants in Type 2 Diabetes Samples Enriched for Family History and Early Age of Onset (2004)

The gene encoding insulin receptor substrate-1 (IRS1) represents a strong biological candidate for a contributory role in type 2 diabetes susceptibility. Indeed, functional studies have implicated the G971R variant, and a recent meta-analysis of 27 association studies suggested that carriage of 971R was associated with a 25% increase in disease risk. However, this association has not been evaluated in large samples. The present study genotyped the P512A and G971R IRS1 variants in 971 U.K. type 2 diabetic subjects ascertained for strong family history and/or early onset, as well as 1,257 control subjects matched by ethnicity. There was no evidence for association with type 2 diabetes for either variant. (For example, the odds ratio [OR] for carriage of 971R was 1.11 [95% CI 0.86-1.44, P = 0.44]) An updated meta-analysis (31 studies: 5,104 case and 7,418 control subjects) remained significant for the G971R association (P = 0.025), albeit with a diminished OR (1.15 [95% CI 1.02-1.31]). Additional studies of IRS1 variation will be required to obtain a robust estimate of the overall contribution of IRS1 variation to type 2 diabetes susceptibility, but the current study suggests that previous studies have overestimated the magnitude of this effect.
Highly Pseudo Ductile Metakaolin Based Engineered Geopolymer Composites Using Low UHMWPE Fiber Content (2021)

The objective of this study was to investigate the effect of fine aggregate type (i.e., natural river sand and manufactured microsilica sand) and ultra-high-molecular-weight polyethylene (UHMWPE) fiber length (i.e., short and long) on the mechanical properties of metakaolin (MK) based Engineered Geopolymer Composites (EGCs) with 0.8 vol.% fiber cured at room temperature. EGCs produced were evaluated by compressive strength test and uniaxial tensile test. Experimental results showed that the compressive strength of the EGCs exceeded that of conventional concrete by ~44–47%, while exhibiting ~19–22% lower densities. However, the compressive strength was not significantly affected by the different types of sand or fibers evaluated. On the other hand, the tensile properties of the EGCs were significantly affected by the type of sand used. The use of natural river sand (RS) in specimens using long UHMWPE fiber, produced a dramatic increase in the tensile strain capacity (i.e., 129%) and a reduction in the tensile strength (i.e., 41%) in contrast to specimens manufactured using microsilica sand (MS). Nevertheless, the different types of fiber evaluated did not produce a substantial effect in the tensile properties of the composites. Notably, the EGC material using natural river sand and long UHMWPE fiber at 0.8 vol.%, presented an exceptional tensile strain capacity of 8.6%, which is comparable to that of some metals. It was concluded that metakaolin-based geopolymers matrices with UHMWPE fibers are highly promising for the manufacture of EGC materials.
Integrated Analyses of microRNAs Demonstrate Their Widespread Influence on Gene Expression in High-Grade Serous Ovarian Carcinoma (2012)

This study establishes miRNAs as having a widespread impact on gene expression programs in ovarian cancer, further strengthening our understanding of miRNA biology as it applies to human cancer. As with gene transcripts, miRNAs exhibit high diversity reflecting the genomic heterogeneity within a clinically homogeneous disease population. Putative miRNA:mRNA interactions, as identified using integrative analysis, can be validated. TCGA data are a valuable resource for the identification of novel tumor suppressive miRNAs in ovarian as well as other cancers.
The Effect of Including Tracer Data in the EnKF Approach (2008)

Abstract This paper presents for the first time: Coupling of the EnKF methodology and tracer data, a new developed tracer simulator which accounts for partitioning gas tracers, and coupling of the EnKF methodology with partitioning gas tracer data. The ensemble Kalman Filter (EnKF) has recently gained popularity as a method for history matching. The EnKF includes online update of parameters and the dynamical states. An ensemble of model representations is used to represent the model uncertainty. Tracers are widely used to increase the understanding of fluid flow. Tracers can be used to label injection fluids, hence, well connections and fluid patterns can be established when the tracer appears in production wells. Tracer data contains valuable information but are typically underexploited; most of the tracer-tests are only evaluated in a qualitative manner, without any kind of comparison to simulation results. This paper brings together tracer and modelling competence by including tracer data as measurements in the EnKF methodology. Gas tracers in reservoirs are partitioning tracers and must be modelled as such. This requires that adequate options are available for modelling of these tracers, both with respect to convection terms and diffusion/dispersion terms in the conservation equation. In this paper we therefore present a new tracer simulator, which includes partitioning of gas tracers. The tracer simulator includes separate time step control and a second order spatial numerical scheme to reduce numerical smearing of the tracer data, and has been coupled with the EnKF methodology. The value of tracer data, and partitioned tracer data, in the EnKF approach is demonstrated on North Sea based examples. The permeability and fault transmissibility multipliers of the reservoirs are estimated by EnKF. These examples show that tracer data can be used successfully in an automatic updating scheme, not only by the traditionally manual updating.
Those are Your Legs: The Effect of Visuo-Spatial Viewpoint on Visuo-Tactile Integration and Body Ownership (2015)

Experiencing a body part as one's own, i.e., body ownership, depends on the integration of multisensory bodily signals (including visual, tactile, and proprioceptive information) with the visual top-down signals from peripersonal space. Although it has been shown that the visuo-spatial viewpoint from where the body is seen is an important visual top-down factor for body ownership, different studies have reported diverging results. Furthermore, the role of visuo-spatial viewpoint (sometime also called first-person perspective) has only been studied for hands or the whole body, but not for the lower limbs. We thus investigated whether and how leg visuo-tactile integration and leg ownership depended on the visuo-spatial viewpoint from which the legs were seen and the anatomical similarity of the visual leg stimuli. Using a virtual leg illusion, we tested the strength of visuo-tactile integration of leg stimuli using the crossmodal congruency effect (CCE) as well as the subjective sense of leg ownership (assessed by a questionnaire). Fifteen participants viewed virtual legs or non-corporeal control objects, presented either from their habitual first-person viewpoint or from a viewpoint that was rotated by 90°(third-person viewpoint), while applying visuo-tactile stroking between the participants legs and the virtual legs shown on a head-mounted display. The data show that the first-person visuo-spatial viewpoint significantly boosts the visuo-tactile integration as well as the sense of leg ownership. Moreover, the viewpoint-dependent increment of the visuo-tactile integration was only found in the conditions when participants viewed the virtual legs (absent for control objects). These results confirm the importance of first person visuo-spatial viewpoint for the integration of visuo-tactile stimuli and extend findings from the upper extremity and the trunk to visuo-tactile integration and ownership for the legs.
The Severity of Nocturnal Hypoxia but Not Abdominal Adiposity Is Associated with Insulin Resistance in Non-Obese Men with Sleep Apnea (2013)

Thus, excess abdominal adiposity in non obese apneic men was associated with a deteriorated insulin-sensitivity that could be driven by a more severe nocturnal hypoxemia.