gebhart/patrepeval huggingface dataset:
Analysis of the invasiveness of <em>Salmonella abortusovis</em> and other host-specific serotypes in sheep (1998)

S. abortusovis is an ovine-specffic pathogen which causes abortion in sheep and septicaemia in Lambs. The molecular basis of this host-specfficity is not untlerstood and may be influenced by the ability ofthis serotype to invade sheep. Therefore the invasiveness ofS.
Efficient gene delivery with paclitaxel-loaded DNA-hybrid polyplexes based on cationic polyhedral oligomeric silsesquioxanes (2010)

We present a novel hybrid cationic polymer based on polyhedral oligomeric silsesquioxanes (POSS). This is the first report of using a cationic POSS-based material for gene delivery. Due to its amphiphilic properties, hydrophobic drugs such as paclitaxel can be encapsulated within the hydrophobic core of this polymer. In this paper, it is shown that paclitaxel-encapsulated hybrid POSS-based polyplexes show superior gene transfection efficiency in human breast cancer cells than the non drug-loaded polyplexes.
Subsurface fluid flow and its implications for seabed pockmarks and mud volcanoes: An approach of distinct element method (DEM) (2007)

Mud volcanoes, seabed pockmarks and seepages are spectacular geological aspects that occur around the world especially in submarine environments. They are formed in resulting from fluid venting through the seabed or by the expulsion of gas or water from the sediment, typically in areas of rapid and extensive sedimentation, causing abnormal fluid pressure that drives overthrust faults. Subsurface fluid flow is important natural process that has an effect on all physical, chemical, and mechanical properties of sedimentary rocks that may be hazards or benefits for human life as well as oil and gas exploration and production. However, dynamic and driving mechanism of this geological process still remains unknown. In this study, we use the distinct element method (DEM), which solves mass and momentum equations for fluid velocities and pressures based on Navier‐Stokes equation for a fluid interacting with a solid phase to simulate fluid‐particle flow in heterogeneous media. As a result, we produce realistic 2‐dimensional geologic configurations from DEM simulation that can be matched either with some observed natural features or in seismic data, such as: mud volcanoes or pockmarks. We conclude that DEM method is applicable and appropriate for describing natural phenomena. This method, therefore, should be widely applied to simulate various nature scenarios.
INTERACTION OF PLATELET FACTOR 4 WITH HEPATOCYTES AND ITS POSSIBLE SIGNIFICANCE IN HEMOSTASIS (1987)

Previous experiments have demonstrated the rapid clearance of himan platelet factor 4 (PF4) from rabbit and rat blood, its accumulation in the liver and its elimination of PF4 degradation products with urine. Injection of heparin resulted in a rapid loss of 125 i-pF4-radioactivity from the liver (Rucinski et al Amer. J. Physiol. 251, H800, 1986). Current experiments demonstrate the uptake of human 125i-pf4 by hepatocytes reaching maximum at 180 min. This uptake is 2-3 times greater at 37°C than at 4°C. At 37°C degradation of 125I-PF4 by hepatocytes was also observed as indicated by the increase of 125j_pf4 radioactivity soluble in 6% trichloracetic acid. By contrast, no uptake of 125I-β was observed. Autoradiography demonstrated association of l25I-PF4 with hepatocytes membranes while after longer incubation (20-60 min) radioactivity was also localized in endosanes. The heparin inhibited binding and uptake of PF4 by hepatocytes; accordingly the injection of heparin to or into rabbits within 10 min resulted in a rapid urinary clearance of 125I-PF4 and the injection of PF4 resulted in a rapid urinary clearance of 3H-heparin. We propose that 1) PF4 released to the circulating blood by activated platelets is bound to the surface of hepatocytes and that it is further processed by these cells over time; 2) the presence of PF4 in the liver may contribute to the regulation of hemostasis by neutralizing anticoagulant activity of endogenous heparin-like molecules; 3) in clinical situations PF4 may enhance clearance of injected heparin by accelerating its urinary excretion.
Peroral Amphotericin B Polymer Nanoparticles Lead to Comparable or Superior In Vivo Antifungal Activity to That of Intravenous Ambisome® or Fungizone™ (2011)

The present investigation describes an efficient way of producing AMB-NPs with higher AMB pay-load and entrapment efficiency employing DMSO as solvent and ethanol as non-solvent. The developed oral formulation was highly efficacious in murine models of disseminated aspergillosis as well as an invasive pulmonary aspergillosis, which is refractory to treatment with IP Fungizone™ and responds only modestly to AmBisome®.
Role of Interferon-γ in promoting disease severity in neonatal Bordetella pertussis infection (2018)

Abstract Pertussis is an infectious disease caused by the bacterial pathogen Bordetella pertussis. In recent years, there has been a re-emergence of pertussis disease. Pertussis morbidity is extensive and spans across all age groups, but a higher incidence of severe disease and mortality is exhibited in young infants. Mortality is associated with severe respiratory infection and other systemic secondary co-morbidities. The infant immune system has reduced capacity to generate proinflammatory/T-helper (Th) 1 cell polarizing responses. Secretion of Interferon gamma (IFN-γ), a Th1 polarizing cytokine, by immune cells plays a critical role in macrophage activation and microbicidal activity in the lung. Furthermore, B. pertussis respiratory challenge of adult IFN-γ receptor deficient mice results in systemic dissemination and lethality. We hypothesize that the dissemination and lethality observed in our neonatal mouse model is a result of inadequate IFN-γ signaling or production, which contribute to insufficient control of the infection. We found that B. pertussis infection results in a significantly lower level of transcription of IFN-γ in the lungs and increased bacterial dissemination in neonatal mice when compared to adult mice. Additionally, infected neonatal mice deficient in IL-10, a potent regulator of IFN-γ, showed reduced dissemination and significantly increased IFN-γ and other pro-inflammatory cytokines as compared to age-matched wild type mice. Future studies include characterization of IFN-γ secreting immune cells during infection. Results generated by this work will contribute to a better understanding of severe disease in infants, addressing the limitations of infant immunity and treatment options for pertussis.
Table S4 from CD8<sup>+</sup> T–cell Immune Surveillance against a Tumor Antigen Encoded by the Oncogenic Long Noncoding RNA <i>PVT1</i> (2023)

&lt;p&gt;Table S4&lt;/p&gt;
tt¯production cross section inpp¯collisions ats=1.8TeV (2003)

Results are presented on a measurement of the $t\overline{t}$ pair production cross section in $p\overline{p}$ collisions at $\sqrt{s}=1.8\mathrm{TeV}$ from nine independent decay channels. The data were collected by the D\O{} experiment during the 1992--1996 run of the Fermilab Tevatron Collider. A total of 80 candidate events is observed with an expected background of $38.8\ifmmode\pm\else\textpm\fi{}3.3$ events. For a top quark mass of $172.1\mathrm{GeV}{/c}^{2},$ the measured cross section is $5.69\ifmmode\pm\else\textpm\fi{}1.21(\mathrm{stat})\ifmmode\pm\else\textpm\fi{}1.04(\mathrm{syst})\mathrm{pb}.$
Expression, purification and preliminary structural analysis of the head domain ofDeinococcus radioduransRecN (2011)

Deinococcus radiodurans has developed an efficient mechanism which allows the integrity of its entire genome to be fully restored after exposure to very high doses of ionizing radiation. Homologous recombination plays a crucial role in this process. RecN is a protein that belongs to the SMC-like protein family and is suggested to be involved in DNA repair. RecN is composed of a globular domain and an antiparallel coiled-coil region which connects the N- and C-termini. It has been suggested that dimerization of RecN occurs via the coiled-coil domain, but to date there is no structural or biochemical evidence for this. Here, SAXS studies and preliminary X-ray diffraction data of crystals of the purified coiled-coil domain of RecN are presented. The structure was solved by single-wavelength anomalous dispersion using SeMet derivatives, and preliminary electron-density maps support the rod-like model derived from the SAXS data. Model building and refinement are still ongoing.
Photochemistry of phenoxybenzyl alcohols in aqueous solution: photosolvolysis vs. photorearrangement to 6H-dibenzo[b,d]pyrans (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotochemistry of phenoxybenzyl alcohols in aqueous solution: photosolvolysis vs. photorearrangement to 6H-dibenzo[b,d]pyransC. G. Huang and Peter WanCite this: J. Org. Chem. 1991, 56, 16, 4846–4853Publication Date (Print):August 1, 1991Publication History Published online1 May 2002Published inissue 1 August 1991https://pubs.acs.org/doi/10.1021/jo00016a009https://doi.org/10.1021/jo00016a009research-articleACS PublicationsRequest reuse permissionsArticle Views302Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Chemical Applications of Molecular Recognition of Antibodies. (1992)

Recently, the molecular recognition by monoclonal antibodies has been utilized widely in the field of organic chemistry. In this article. application of monoclonal antibodies in photochemistry was reviewed. Attention was focused on a photoreversible uptake and release of photochromic hapten peptides and on a photopatterning of antibodies on a surface carrying hapten peptides.
Finding Thoughtful Comments from Social Media (2012)

Online user comments contain valuable user opinions. Comments vary greatly in quality and detecting high quality comments is a subtask of opinion mining and summarization research. Finding attentive comments that provide some reasoning is highly valuable in understanding the user’s opinion particularly in sociopolitical opinion mining and aids policy makers, social organizations or government sectors in decision making. In this paper we study the problem of detecting thoughtful comments. We empirically study various textual features, discourse relations and relevance features to predict thoughtful comments. We use logistic regression model and test on the datasets related to sociopolitical content. We found that the most useful features include the discourse relations and relevance features along with basic textual features to predict the comment quality in terms of thoughtfulness. In our experiments on two different datasets, we could achieve a prediction score of 79.37% and 73.47% in terms of F-measure on the two data sets, respectively.
Suggesting Reviewers to Improve Your Manuscript (2021)

ADVERTISEMENT RETURN TO ISSUEViewpointNEXTSuggesting Reviewers to Improve Your ManuscriptAnastassia N. AlexandrovaAnastassia N. AlexandrovaUniversity of California, Los Angeles, Los Angeles, California 90095, United StatesMore by Anastassia N. Alexandrovahttps://orcid.org/0000-0002-3003-1911 and Gregory V. HartlandGregory V. HartlandUniversity of Notre Dame, Notre Dame, Indiana 46556, United StatesMore by Gregory V. Hartlandhttps://orcid.org/0000-0002-8650-6891Cite this: J. Phys. Chem. C 2021, 125, 27, 14493–14494Publication Date (Web):June 30, 2021Publication History Published online30 June 2021Published inissue 15 July 2021https://pubs.acs.org/doi/10.1021/acs.jpcc.1c05523https://doi.org/10.1021/acs.jpcc.1c05523editorialACS PublicationsCopyright © Published 2021 by American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views11050Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (892 KB) Get e-AlertscloseSUBJECTS:Continuing education,Physical chemistry,Students Get e-Alerts
Color computer-generated holograms from projection images (2004)

A novel method for the procurement of full-color three-dimensional (3-D) images of real objects has been developed. This method is based on extracting information from 3-D Fourier spectra, which are calculated from several projection images recorded using a white light source. 3-D Fourier spectra for three colors were obtained separately for projection images recorded with a color-CCD camera. Three computer-generated holograms (CGHs) were then synthesized from those Fourier spectra. The resulting numerically and optically reconstructed full-color images are presented.
Paradoxical Increase of Stroke in Patients with Defect of High Molecular Weight Multimers of the von Willebrand Factors following Transcatheter Aortic Valve Replacement (2020)

MLBCs and CT-ADP > 180 seconds were identified as predictors for ischemic stroke or TIA. The present study suggests that the defects of HMW multimers of the VWFs may contribute not only to bleeding events but also to thrombotic events.
Effect of Trimetazidine on Postischemic Regional Myocardial Stunning in the Halothane-Anesthetized Dog (1996)

Trimetazidine (TMZ) has been described as a new antiischemic agent. Whereas its precise mechanism of action remains unknown, antioxidant properties and the ability to preserve high-energy phosphate metabolism have been reported. Accordingly, we studied whether TMZ may limit postischemic regional myocardial stunning (known to be caused by reactive oxygen species) and influence recruitment of contractile reserve by inotropic stimulation in a dog model, using halothane to maintain steady anesthesia throughout the experiment. Dogs were submitted to a 15-min coronary artery occlusion followed by reperfusion. The blinded protocol included a 3-day oral pretreatment (1 mg/kg/day), a bolus injection (0.5 mg/kg), followed by intravenous infusion (0.5 mg/h) initiated 15 min before coronary artery occlusion. Despite lower heart rate (HR) and significant reduction of lipid peroxidation in treated dogs, myocardial stunning and recruitment of contractile reserve by dobutamine infusion in the postischemic myocardium were not modified by TMZ. Adenine nucleotide pool in the postischemic myocardium was considerably reduced as compared with the nonischemic myocardium in both groups. Therefore, in halothane-anesthetized dogs, the antioxidant properties of TMZ were not sufficient to protect myocardium in terms of postischemic dysfunction after 15-min ischemia.
Together we stand: Siamese Networks for Similar Question Retrieval (2016)

Community Question Answering (cQA) services like Yahoo! Answers 1 , Baidu Zhidao 2 , Quora 3 , StackOverflow 4 etc. provide a platform for interaction with experts and help users to obtain precise and accurate answers to their questions. The time lag between the user posting a question and receiving its answer could be reduced by retrieving similar historic questions from the cQA archives. The main challenge in this task is the "lexicosyntactic" gap between the current and the previous questions. In this paper, we propose a novel approach called "Siamese Convolutional Neural Network for cQA (SCQA)" to find the semantic similarity between the current and the archived questions. SCQA consist of twin convolutional neural networks with shared parameters and a contrastive loss function joining them.
Natural Gas Compressor Operation Optimization to Minimize Gas Turbine Outboard Bleed Air (2012)

Gas turbine (GT) engines employed in natural gas compressor stations operate in different modes depending on the power, turbine inlet temperature and shaft speeds. These modes apply different sequencing of bleed valve opening on the air compressor side of the engine. Improper selection of the GT and the driven booster compressor operating conditions can lead to larger bleed losses due to wider bleed valve openings. The bleed loss inevitably manifests itself in the form of higher overall heat rate of the GT and greater engine emission. It is therefore imperative to determine and understand the engine and process conditions that drive the GT to operate in these different modes. The ultimate objective is to operate the engine away from the inefficient modes by adjusting the driven booster compressor parameter as well as the overall station operating conditions (i.e. load sharing, control set points, etc.). This paper describes a methodology to couple the operating conditions of the booster compressor to the modes of GT bleed valve opening (and the subsequent air bleed rates) leading to identification of the operating parameters for optimal performance (i.e., best overall efficiency and minimum CO2e emission). A predictive tool is developed to quantify the overall efficiency loss as a result of the different bleed opening modes, and map out the condition on the gas compressor characteristics. One year’s worth of operating data taken from an existing compressor station on TransCanada Pipelines’ Alberta system was used to demonstrate the methodology. This station employs GE-LM1600 gas turbine driving a Cooper Rolls-RFBB-30 centrifugal compressor. The results from the analysis conclusively indicate that there are operating regions on the gas compressor map where losses due to bleed valves are reduced and hence lower CO2 emissions, which presents an opportunity for operation optimization.
Polarizing-alignment layers for twisted nematic cells (2000)

Abstract We describe polarizing films formed from the lyotropic liquid crystalline phases of dyes dissolved in water. The dye polarizers possess a high dichroic ratio close to that of conventional polarizers. In addition, the dried dye films provide a uniform homogeneous orientation for thermotropic nematic materials. Therefore, thin dye films can simultaneously serve as internal polarizers and as alignment agents. These properties make them especially suitable for twisted nematic devices based on low cost birefringent plastic substrates.
Automation of Pressure Control Improves Whole Porcine Heart Decellularization (2015)

Whole heart decellularization combined with patient-specific cells may prove to be an extremely valuable approach to engineer new hearts. Mild detergents are commonly used in the decellularization process, but are known to denature and solubilize key proteins and growth factors and can therefore be destructive to the extracellular matrix (ECM) during the decellularization process. In this study, the decellularization of porcine hearts was accomplished in 24 h with only 6 h of sodium dodecyl sulfate exposure and 98% DNA removal. Automatically controlling the pressure during decellularization reduced the detergent exposure time while still completely removing immunogenic cell debris. Stimulation of macrophages was greatly reduced when comparing native tissue samples to the processed ECM. Complete cell removal was confirmed by analysis of DNA content. General collagen and elastin preservation was demonstrated. Glycosaminoglycans and collagen quantification both showed no significant differences in content after decellularization. The compression elastic modulus of the ECM after decellularization was lower than native at low strains, but there was no significant difference at high strains. Polyurethane casts of the vasculature of native and decellularized hearts demonstrated that the microvasculature network was preserved after decellularization. A static blood thrombosis assay using bovine blood was also developed. Finally, the recellularization potential of the ECM samples was demonstrated by reseeding cardiac fibroblasts and endothelial cells on the myocardium and endocardium samples.
The effect of the time dependent angular distribution of the intergrain magnetic field on the transport critical current in Ag-(Bi,Pb)2Sr2Ca2Cu3Ox tapes (1996)

Changes in the energy dissipation of the tape form Ag-(Bi,Pb)2Sr2Ca2Cu3Ox conductor have been interpreted in terms of magnetic flux movement from, or into, the intergrain regions of the highly textured plate like grain structure. The time dependent increase or decrease of the transport critical current (Ic), originates from time dependent angular superposition of the current induced self field (HSF), and external magnetic field [field cooling (HFC), and zero-field cooling (HZFC)] at the intergrain regions. The existence of time dependent changes of Ic can be explained in terms of the time dependent flux redistribution in grains and grain boundaries caused by thermal relaxation processes.
Reduced complexity in-phase/quadrature-phase turbo equalisation using iterative channel estimation (2002)

A novel reduced complexity trellis-based equaliser, referred to as the in-phase/quadrature-phase equaliser (I/Q-EQ), is proposed. The I/Q-EQ is employed in the context of turbo equalisation (TEQ-IQ) and with the aid of iterative channel estimation. The performance of the TEQ-IQ is characterized in a noise limited environment over an equally-weighted, symbol-spaced three-path Rayleigh fading channel. The TEQ-IQ achieved the same performance as the conventional turbo equaliser, while achieving a complexity reduction by a factor of 1.25 and 7.17 for 4-QAM and 16-QAM, respectively.