gebhart/patrepeval huggingface dataset:
Clinical characteristics and registry-validated extended pedigrees of germline TP53 mutation carriers in Denmark (2018)

Germline TP53 mutations in Denmark are likely to be drastically underdiagnosed despite their severe phenotype. Following recent advances in surveillance options of LFS patients, lack of pre-symptomatic testing may lead to the mismanagement of some individuals.
Microfocused ultrasound for skin tightening. (2013)

The demand for noninvasive skin tightening procedures is increasing as patients seek safe and effective alternatives to aesthetic surgical procedures of the face, neck, and body. Over the past decade, radiofrequency and infrared laser devices have been popularized owing to their ability to deliver controlled heat to the dermis, stimulate neocollagenesis, and effect modest tissue tightening with minimal recovery. However, these less invasive approaches are historically associated with inferior efficacy so that surgery still remains the treatment of choice to address moderate to severe tissue laxity. Microfocused ultrasound was recently introduced as a novel energy modality for transcutaneous heat delivery that reaches the deeper subdermal connective tissue in tightly focused zones at consistent programmed depths. The goal is to produce a deeper wound healing response at multiple levels with robust collagen remodeling and a more durable clinical response. The Ulthera device (Ulthera, Inc, Meza, AZ), with refined microfocused ultrasound technology, has been adapted specifically for skin tightening and lifting with little recovery or risk of complications since its introduction in 2009. As clinical parameters are studied and optimized, enhanced efficacy and consistency of clinical improvement is expected.
Immune Responses against Salmonella enterica Serovar Enteritidis Infection in Virally Immunosuppressed Chickens (2003)

To understand the role of immune mechanisms in protecting chickens from Salmonella infections, we examined the immune responses of Salmonella enterica serovar Enteritidis-infected chickens and the effect of chicken anemia virus (CAV), a T-cell-targeted virus, on S. enterica serovar Enteritidis-induced immune responses. One-day-old chicks were orally inoculated with S. enterica serovar Enteritidis with or without intramuscular injection of CAV. The bacterial infection, pathology, and immune responses of chickens were evaluated at 14, 28, and 56 days postinoculation. The infection increased the levels of S. enterica serovar Enteritidis-specific mucosal immunoglobulin A (IgA), the number of gut-associated T cells, and the titer of serum IgG specific for S. enterica serovar Enteritidis surface antigens. CAV infection depressed these immune responses, especially the mucosal immune responses, but did not increase the number of S. enterica serovar Enteritidis-infected cells in the intestine. The severity of pathological lesions appeared to be reciprocal to the level of immune responses, but the S. enterica serovar Enteritidis infection persisted. These results suggest that oral infection of S. enterica serovar Enteritidis in chickens induces both mucosal and systemic immune responses, which have a limited effect on the S. enterica serovar Enteritidis infection under conditions designed to mimic the field situation.
Anatomy of the prostate and distribution of early prostate cancer (1995)

Many of the difficulties in understanding diseases of the prostate have arisen through poor understanding of the anatomy of the prostate. The recent description of histologically separate zones in the prostate has been an important advance, allowing evaluation of separate cancers arising in the transition and peripheral zones of the prostate. While the majority of cancers sampled at transurethral resection of the prostate (TURP) are of transition zone origin, most of these prostates contain separate cancers in the peripheral zone. The peripheral zone cancers have a higher grade-to-volume ratio and are more frequently associated with histological features of progression (extracapsular extension, seminal vesicle invasion) than transition zone cancers. Furthermore, peripheral zone cancers are frequently associated with prostatic intraepithelial neoplasia, in contrast to transition zone cancers. These findings suggest a greater biological activity for cancers arising in the peripheral zone. The majority of cancers detected by digital rectal examination are of peripheral zone origin. While associated transition zone cancers are less frequently present than in TURP sampled prostates, a similarly high association of peripheral zone cancers with histological indicators of biological activity is seen. DNA ploidy analysis of separate foci in radical prostatectomy specimens confirms a significantly higher rate of non-diploidy in cancers of peripheral zone origin, some of very small volume, which further suggests a greater biological activity compared to transition zone cancers.
ChemInform Abstract: Clay‐Catalyzed Facile Beckmann Rearrangement of Ketoximes. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
4,6-O-benzylidene-3-deoxy-3-C-(iodomethyl)-D-glucal(4,6-O-benzylidene-1,2,3-trideoxy-3-C-iodomethyl-D-arabino-hex-1-enopyranose) (1970)

B. Fraser-Reid and B. Radatus, J. Chem. Soc. D, 1970, 779 DOI: 10.1039/C29700000779
The relationship between upper limb function and activities of daily living without the effects of lower limb function: A cross-sectional study (2021)

The relationship between upper limb motor function and ADL is strongly influenced by lower limb motor function.
Adaptive Intrusion Detection Based on Machine Learning: Feature Extraction, Classifier Construction and Sequential Pattern Prediction (2006)

Abstract: In recent years, intrusion detection has emerged as an important technique for network security. Due to the large volumes of security audit data as well as complex and dynamic properties of intrusion behaviors, to optimize the performance of intrusion detection systems (IDSs) becomes an important open problem. In this paper, a general framework of adaptive intrusion detection based on machine learning is presented. In the framework, three perspectives of challenging problems are explored, which include feature extraction, classifier construction and pattern prediction for sequential data. It is illustrated that the three perspectives of research challenges are mainly suitable for machine learning methods using unsupervised, supervised and reinforcement learning algorithms, respectively. Several recently developed machine learning algorithms, including a multi-class support vector machine with principal component analysis (PCA) for feature reduction and a reinforcement learning algorithm for sequential prediction, are applied and evaluated both on network-based traffic data and on host-based program behaviors. Experiments on the KDD99 intrusion detection data set and the system call data from University of New Mexico show very promising results for the machine learning approaches to adaptive intrusion detection. Some directions for future research works are also discussed.
In-Field Implementation of a Recombinant Factor C Assay for the Detection of Lipopolysaccharide as a Biomarker of Extant Life within Glacial Environments (2012)

The discovery over the past two decades of viable microbial communities within glaciers has promoted interest in the role of glaciers and ice sheets (the cryosphere) as contributors to subglacial erosion, global biodiversity, and in regulating global biogeochemical cycles. In situ or in-field detection and characterisation of microbial communities is becoming recognised as an important approach to improve our understanding of such communities. Within this context we demonstrate, for the first time, the ability to detect Gram-negative bacteria in glacial field-environments (including subglacial environments) via the detection of lipopolysaccharide (LPS); an important component of Gram-negative bacterial cell walls. In-field measurements were performed using the recently commercialised PyroGene® recombinant Factor C (rFC) endotoxin detection system and used in conjunction with a handheld fluorometer to measure the fluorescent endpoint of the assay. Twenty-seven glacial samples were collected from the surface, bed and terminus of a low-biomass Arctic valley glacier (Engabreen, Northern Norway), and were analysed in a field laboratory using the rFC assay. Sixteen of these samples returned positive LPS detection. This work demonstrates that LPS detection via rFC assay is a viable in-field method and is expected to be a useful proxy for microbial cell concentrations in low biomass environments.
About this issue - Metaphorical Pachyderm (2008)

Provides an overview of the technical articles and features presented in this issue.
Cadmium copper tetrachloride tetrahydrate (2000)

The double salt [CuCl2(H2O)2{CdCl2}]·2H2O crystallizes in the triclinic rather than the monoclinic system as reported previously. The structure consists of sheets in the ac plane with slightly distorted octahedral CdCl6 [Cd—Cl 2.5813 (8)–2.6943 (8) Å] connected by Cd—Cl—Cd bridges in the Cd equatorial plane along a, and by Cd—Cl—Cu bridges to layers of square-planar CuCl2(H2O)2 along c. There are long axial Cu—Cl interactions of 2.8623 (7) Å and additional water of hydration is hydrogen bonded to coordinated water and chloride ligands. The additional water connects the ac sheets into a three-dimensional network. Both Cd and Cu occupy different P\overline 1 sites. The Cu⋯Cu and Cd⋯Cd distances are 3.8274 (6) Å.
Introducing Nafion for In Situ Desalting and Biofluid Profiling in Spray Mass Spectrometry (2022)

We introduce Nafion into the ambient ionization technique of spray mass spectrometry to serve for <i>in situ</i> desalting and direct analysis of biological fluids. Nafion was coated onto the surface of the triangular spray tip as the cation exchange material. Because the sulfonic group from the Nafion membrane effectively exchanges their carried protons with inorganic salt ions (e.g., Na<sup>+</sup> and K<sup>+</sup>), the analyte's ionization efficiency can be significantly enhanced by reducing ion suppression. The desalting efficiency can reach 90% and the maximum tolerance of the absolute salt amount reaches 100 μmol. The mass spectral profile can also be simplified by removing the multiple adducted ion types from small-molecule drugs and metabolites ([M + Na]<sup>+</sup> and [M + K]<sup>+</sup>), or multiply charged ions formed by proteins ([M + nNa]<sup>n+</sup> and [M + nK]<sup>n+</sup>). Thus, the Nafion coating makes less ambiguous data interpretation collected from spray mass spectrometry for qualitative profiling or quantitative measurement of a target analyte.
Silk Vista Baby for the Treatment of Complex Posterior Inferior Cerebellar Artery Aneurysms (2022)

The SVB device was safely and effectively used in the treatment of PICA aneurysms. The smaller delivery system profile reduces the risk of procedure complications and creates new treatment options for distal lesions.
Image Inversion Spectral-Domain Optical Coherence Tomography Optimizes Choroidal Thickness and Detail through Improved Contrast (2012)

The most favorable modes to visualize CSJ and OCV are the Spectralis EDI, Spectralis inverted, Cirrus upright, and Bioptigen inverted. These modes demonstrate the highest outer choroidal contrast and choroidal thickness measurements. Choroidal thickness cannot be compared between machines due to conversion factor differences. Future studies and construction of automated segmentation and detection software should take these benefits and pitfalls into account.
Isolation and Cloning of 17 Novel C(2)H(2) Zinc Finger Gene Fragments. (1998)

A pair of degenerate primers were designed according to the DNA sequences of the C(2)H(2) zinc finger genes conservative domain and then homologious PCR was performed with the human genomic total DNA as template. The zinc finger fragments thus obtained were used as probes to screen cDNA libraries of human fetal kidney, muscle and marrow and 22 C(2)H(2) zinc finger gene fragments were selected. Among these fragments, 17 were confirmed to be novel zinc finger gene fragments by literature searches in the National Center Biotechnology Information (NCBI) database. Expression patterns of the clones K3-4 and K5-12 selected from kidney cDNA library were analyzed. The results showed that the expression level of K3-4 in kidney is obviously higher than in other tissues and K5-12 is expressed at different levels in 8 tissues.
All-Polycarbonate Thermoplastic Elastomers Based on Triblock Copolymers Derived from Triethylborane-Mediated Sequential Copolymerization of CO2 with Various Epoxides (2020)

Various oxirane monomers including alkyl ether or allyl-substituted ones such as 1-butene oxide, 1-hexene oxide, 1-octene oxide, butyl glycidyl ether, allyl glycidyl ether, and 2-ethylhexyl glycidyl ether were anionically copolymerized with CO<sub>2</sub> into polycarbonates using onium salts as initiator in the presence of triethylborane. All copolymerizations exhibited a "living" character, and the monomer consumption was monitored by <i>in situ</i> Fourier-transform infrared spectroscopy. The various polycarbonate samples obtained were characterized by <sup>1</sup>H NMR, GPC, and differential scanning calorimetry. In a second step, all-polycarbonate triblock copolymers demonstrating elastomeric behavior were obtained in one pot by sequential copolymerization of CO<sub>2</sub> with two different epoxides, using a difunctional initiator. 1-Octene oxide was first copolymerized with CO<sub>2</sub> to form the central soft poly(octene carbonate) block which was flanked by two external rigid poly(cyclohexene carbonate) blocks obtained through subsequent copolymerization of cyclohexene oxide with CO<sub>2</sub>. Upon varying the ratio of 1-octene oxide to cyclohexene oxide and their respective ratios to the initiator, three all-polycarbonate triblock samples were prepared with molar masses of about 350 kg/mol and 22, 26, and 29 mol % hard block content, respectively. The resulting triblock copolymers were analyzed using <sup>1</sup>H NMR, GPC, thermogravimetric analysis, differential scanning calorimetry, and atomic force microscopy. All three samples demonstrated typical elastomeric behavior characterized by a high elongation at break and ultimate tensile strength in the same range as those of other natural and synthetic rubbers, in particular those used in applications such as tissue engineering.
Simple guidance method for single stage to low Earth orbit (1995)

A simple, two-phase guidance method based on a cubic-spline representation of the altitude-velocity profile, subject to a dynamic pressure constraint and with pay load as the cost function, is developed for the single-stage to low-Earth-orbit mission. The optimal cubic-spline parameters are determined off-line using a genetic algorithm and reoptimized on-line during the initial phase using a gradient search method. In the terminal phase, a perturbation guidance scheme based on linear quadratic regulator theory and gain scheduling is synthesized to keep the actual vehicle close to the optimal cubic-spline path. This method is applied to a generic booster, and its performance is compared with the optimal solution.
A power-efficient 32b ARM ISA processor using timing-error detection and correction for transient-error tolerance and adaptation to PVT variation (2010)

Razor [1–3] is a hybrid technique for dynamic detection and correction of timing errors. A combination of error-detecting circuits and micro-architectural recovery mechanisms creates a system which is robust in the face of timing errors, and can be tuned to an efficient operating point by dynamically eliminating unused guardbands.
Cysteine Protease B of Leishmania mexicana Inhibits Host Th1 Responses and Protective Immunity (2003)

C3H mice infected with Leishmania mexicana fail to develop a protective Th1 response, and are unable to cure. In this study, we show that L. mexicana cysteine proteases suppress the antileishmanial immune response. Previous studies demonstrated that deletion of the entire multicopy cysteine protease B (CPB) gene array in L. mexicana is associated with decreased parasite virulence, potentially attributable to factors related to parasite fitness rather than to direct effects on the host immune response. We now show that C3H mice infected with the L. mexicana deletion mutant (Deltacpb) initially develop lesions that grow at rates comparable to those of wild-type L. mexicana-infected mice. However, in contrast to controls, Deltacpb-induced lesions heal with an accompanying Th1 immune response. Lesion resolution was Th1 dependent, as Deltacpb-infected IL-12p40(-/-) and STAT4(-/-) mice developed high parasite burdens and progressive disease. Moreover, when L. major was transfected with a cosmid expressing multiple L. mexicana CPB genes, this parasite induced a significantly lower IFN-gamma response compared with wild-type L. major. These data indicate that cysteine proteases of L. mexicana are critical in suppressing protective immune responses and that inhibition of CPB may prove to be a valuable immunomodulatory strategy for chronic forms of leishmaniasis.
Hawkeye: Open source framework for field surveillance (2017)

This paper introduces a generic framework for field surveillance using consumer rotorcrafts and ground vehicles. Building such an autonomous system comes with two key challenges in persistent perception and obstacle avoidance. We begin with explaining two core algorithms to solve the challenges: an auto-landing algorithm that enables a quadrotor to land on a moving ground vehicle at a speed of 6.00 m/s, and an obstacle avoidance algorithm that ensures the safety of the quadrotor during searching process. On the basis of these algorithms, the architecture and infrastructure of Hawkeye framework are presented as well. Hawkeye is designed to be a generic platform with extensibility that allows integration of other domain applications. We demonstrate the potential of Hawkeye framework in a simulated agriculture monitoring mission and report its performance at the end of the paper.
A review of overview+detail, zooming, and focus+context interfaces (2009)

There are many interface schemes that allow users to work at, and move between, focused and contextual views of a dataset. We review and categorize these schemes according to the interface mechanisms used to separate and blend views. The four approaches are overview+detail, which uses a spatial separation between focused and contextual views; zooming, which uses a temporal separation; focus+context, which minimizes the seam between views by displaying the focus within the context; and cue-based techniques which selectively highlight or suppress items within the information space. Critical features of these categories, and empirical evidence of their success, are discussed. The aim is to provide a succinct summary of the state-of-the-art, to illuminate both successful and unsuccessful interface strategies, and to identify potentially fruitful areas for further work.
Early identification and intervention of cerebral palsy (2016)

Cerebral palsy (CP) describes a group of disorders of the development of movement and posture, causing activity limitation attributed to disturbances, which occurred in the fetal or infant brain.Early identification and intervention of CP has always been a difficult topic in the research of neuroscience.The intervention should be focused on infants showing early signs of CP.Such signs may be efficiently detected by a combination of neuroimaging and the General Movements Assessment.Besides movements, enriched environments, active participation, parental coaching have benefits to early intervention.In this investigation, the early identification and intervention in cerebral palsy were focused.


Key words: 
Cerebral palsy; Early identification; Early intervention
Construction and partial characterization of a recombinant DNA probe for locust vitellogenin messenger RNA. (1982)

Double-stranded DNA complementary to poly(A)-containing RNA from the fat body of adult female locusts, Locusta migratoria, was synthesized. Hybrid molecules containing this cDNA was constructed in the PstI site of the plasmid pAT 153 by the technique of dC . dG tailing and amplified in Escherichia coli K-12 strain HB 101. Ten colonies of bacteria were identified as carrying recombinant plasmids containing DNA complementary to locust vitellogenin mRNA by (a) 'Northern' blot hybridization analysis and (b) hybrid selection of vitellogenin mRNA and immunological detection of the products of translation of the mRNA. Of the ten recombinant plasmids, one, termed plasmid 4E, containing a cDNA insert of about 650 nucleotides, was characterized in greater detail and a partial restriction map obtained. Using this hybrid plasmid it was possible to derive a value for the average content of vitellogenin mRNA in the adult female locust fat body as 1.5 x 10(5) molecules/cell, and to establish that the haploid genome of L. migratoria contains only one or two genes coding for vitellogenin.
Metamaterials (2010)

Abstract The sections in this article are Introduction Background Transmission‐Line Theory of LH Media Metamaterial Implementations Metamaterial Applications Beyond Left‐Handedness
One Electrogram-Tracing Tells All: what is the mechanism of this supraventricular tachycardia? (2021)

One Electrogram-Tracing Tells All: what is the mechanism of this supraventricular tachycardia?Moyuru Hirata, MD*, Yuji Wakamatsu, MD*, Koichi Nagashima, MD, PhD*, Sayaka Kurokawa, MD, PhD*, Naoto Otsuka, MD*, Seina Yagyu, MD*, Shu Hirata, MD*, Toshiko Nakai, MD, PhD*, Yasuo Okumura, MD, PhD*.*Division of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, JapanCorrespondenceKoichi Nagashima, MD, PhD; Division of Cardiology, Department of Medicine, Nihon University School of Medicine, 30-1 Ohyaguchi-kamicho, Itabashi-ku, Tokyo 173-8610, JapanTel: +81-3-3972-8111Fax: +81-3-3972-1098E-mail: cocakochan@gmail.comTotal word count: 1036 words, 2 FiguresFunding: (None)Disclosures: (None)The work described was supported by departmental resources only.Keywords: narrow QRS tachycardia, atrioventricular nodal reentrant tachycardia, accessary pathway.
Video-aware time-domain resource partitioning in heterogeneous cellular networks (2015)

Heterogenous cellular networks (HCN) consist of macrocells and small cells that are overlaid in the same geographical area. Hence, is critical that the high power macrocell shuts off its transmissions for a fraction of the time to allow the low power small cells to transmit without interference. This is the time-domain resource partitioning (TDRP) mechanism. In this paper we investigate video communication in HCNs when TDRP is employed. More specifically we consider the problem of maximizing the average video quality of all users, by jointly optimizing the rate allocated to each specific video stream and the quality that it is streamed. The resulting mixed integer linear program (MILP) formulation is solved numerically. Simulation results indicate clearly that as the small cells and the users are increased the proposed system can improve significantly the video quality.
Tardaremos en disponer de un sistema fiable de predicción de terremotos: Julio Mezcua, sismólogo (1998)

Observations included high prevalence of overweight (19%) and obesity (13%) with no difference between type of school, gender, or group of age (Table 2). High prevalence of hipercholesterolemia (26%), LDLcholesterol (7%), HDL hypolipoproteinemia (3%), triglycerides (10%), systolic blood pressure (6%), and metabolic syndrome (1.6%) were also observed. The BMI was associated to total lipid, total cholesterol, insulin, and HOMA-IR levels. The Overweight and obese had higher levels of insulin, HOMA-IR, triglycerides, and blood pressure and lower levels of HDL-cholesterol.