gebhart/patrepeval huggingface dataset:
Ginsenoside compound K, not Rb1, possesses potential chemopreventive activities in human colorectal cancer (2012)

Ginsenoside compound K (C-K) is an intestinal microbiota metabolite of ginsenoside Rb1, a major constituent in American ginseng. However, previous ginseng anti-cancer observations were largely focused on ginseng parent compounds but not metabolites, and anti-colorectal cancer studies on C-K were limited. This study investigated the anti-proliferative effects of C-K when compared to those of Rb1, and the related mechanisms of action, in HCT-116 and SW-480 colorectal cancer cells. The effects of Rb1 and C-K on the proliferation of HCT-116 and SW-480 human colorectal cancer cells were compared using an MTS assay. Cell cycle and cell apoptosis were assayed using flow cytometry. Enzymatic activities of caspases were determined by colorimetric assay, and interactions of C-K and caspases were explored by docking analysis. C-K showed significant anti-proliferative effects in HCT-116 and SW-480 cells at concentrations of 30-50 µM. At the same concentrations, Rb1 did not show any effects, while C-K arrested the cells in the G1 phase, and significantly induced cell apoptosis. Compared to HCT-116 (p53 wild-type), the p53 mutant cell line SW-480 was more sensitive to C-K as assessed by cell cycle regulation and apoptosis induction. C-K activated expression of caspases 8 and 9, consistent with docking analysis. The docking data suggested that C-K forms hydrogen bonds with Lys253, Thr904 and Gly362 in caspase 8, and with Thr62, Ser63 and Arg207 in caspase 9. C-K, but not its parent ginsenoside Rb1, showed significant anti-proliferative and pro-apoptotic effects in human colorectal cancer cells. These results suggest that C-K could be a potentially effective anti-colorectal cancer agent.
Laser deicing for high-voltage composite insulator by high-power mid-infrared fiber laser (2021)

Ice disaster has always been a threat to the stable operation of electrical power systems, and it is a challenge to melt ice online for high-voltage composite insulator. Here, we proposed a safe and efficient method to deice a high-voltage composite insulator using high-power mid-infrared (mid-IR) laser. The laser source is a Tm-doped fiber laser, delivering a continuous-wave (CW) output power of 75 W at 1940 nm. Due to the strong vibration absorption of H2O molecule at 1940 nm, the mid-IR laser could be absorbed efficiently by ice/water with an absorption coefficient as high as 135 cm − 1. Indoor deicing experiment demonstrated that an 8-mm-diameter ice pillar could be cut off within 28 s under an incident optical intensity of 25 W/cm2. Due to the small penetration depth of 148 μm, the residual water film could prevent the laser from damaging the composite insulator. Our research results show that high-power mid-IR Tm-doped fiber laser is a potential scheme for online deicing high-voltage composite insulator.
Size-dependent melting of spherical copper nanoparticles embedded in a silica matrix (2007)

We report size-dependent melting of spherical copper nanoparticles embedded in a silica matrix. Based on the temperature dependence of the surface-plasmon resonance energy and its width, we observe two distinct melting regimes. For particles smaller than $20\phantom{\rule{0.3em}{0ex}}\mathrm{nm}$, the absorption spectrum changes monotonically with the temperature, and this allows us to assume the gradual solid-liquid phase transition (melting) of the nanoparticles or the existence of superheated solid nanoparticles. In contrast, for nanoparticles larger than $20\phantom{\rule{0.3em}{0ex}}\mathrm{nm}$, we observe a jumplike increase of the bandwidth and a nonmonotonic shift of surface-plasmon band with the increase of temperature below the bulk melting point. This indicates that the melting of large nanoparticles is a first-order phase transition similar to the melting of bulk copper.
Role of cage return and solvent viscosity in the temperature-dependent kinetics of benzylic bromination (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRole of cage return and solvent viscosity in the temperature-dependent kinetics of benzylic brominationDennis D. Tanner and Nguyen H. NamCite this: J. Org. Chem. 1987, 52, 21, 4686–4688Publication Date (Print):October 1, 1987Publication History Published online1 May 2002Published inissue 1 October 1987https://doi.org/10.1021/jo00230a006RIGHTS & PERMISSIONSArticle Views94Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (413 KB) Get e-Alerts Get e-Alerts
87: Dynamic Outcome Prediction in Patients with Clear Cell Renal Cell Carcinoma Treated with Radical Nephrectomy (2006)

You have accessJournal of UrologyModerated Poster, Saturday, May 20, 2006, 3:30 - 5:30 pm1 Apr 200687: Dynamic Outcome Prediction in Patients with Clear Cell Renal Cell Carcinoma Treated with Radical Nephrectomy Igor Frank, Bradley C. Leibovich, Christine M. Lohse, John C. Cheville, Horst Zincke, and Michael L. Blute Igor FrankIgor Frank More articles by this author , Bradley C. LeibovichBradley C. Leibovich More articles by this author , Christine M. LohseChristine M. Lohse More articles by this author , John C. ChevilleJohn C. Cheville More articles by this author , Horst ZinckeHorst Zincke More articles by this author , and Michael L. BluteMichael L. Blute More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)32354-1AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "87: Dynamic Outcome Prediction in Patients with Clear Cell Renal Cell Carcinoma Treated with Radical Nephrectomy." The Journal of Urology, 175(4S), p. 28 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 175Issue 4SApril 2006Page: 28 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Igor Frank More articles by this author Bradley C. Leibovich More articles by this author Christine M. Lohse More articles by this author John C. Cheville More articles by this author Horst Zincke More articles by this author Michael L. Blute More articles by this author Expand All Advertisement PDF DownloadLoading ...
Long-lived charge-separated states produced in supramolecular complexes between anionic and cationic porphyrins (2014)

Photoinduced electron transfer in a porphyrin supramolecule occurs to produce an 83 ms CS state.
Choosing my partners based on how they will evaluate my behavior (2014)

In nowadays reputation systems, future partners are selected based solely on their reputation values calculated according to their behavior in providing services. However, an agent that intends to participate in future interactions may concern not only about the quality of the services it provides, but also about how its partners evaluate its behavior since such evaluation may be transmitted to other agents that will use it to select their partners. In this context, this paper proposes two mechanisms able (i) to help an agent to identify how a colleague evaluates the behavior of its partners and (ii) to estimate the reputation the agent using the approach will probably receive after interacting with such colleague. The agent then puts together the reputation value associated with the quality of the services provided by the colleague and the reputation it will receive if interacts with such colleague in order to evaluate if such colleague may be selected or not as a future partner. The approach was evaluated by using an e-commerce scenario.
Genomic expression and single-nucleotide polymorphism profiling discriminates chromophobe renal cell carcinoma and oncocytoma (2010)

Gene expression profiles, high-throughput SNP genotyping, and pathway analysis effectively distinguish chRCC from oncocytoma. We have generated a novel transcript predictor that is able to discriminate between the two entities accurately, and which has been validated both in an internal and an independent data-set, implying generalizability. A cytogenetic alteration, loss of chromosome 1p, common to renal oncocytoma and chRCC has been identified, providing the opportunities for identifying novel tumor suppressor genes and we have identified a series of immunohistochemical markers that are clinically useful in discriminating chRCC and oncocytoma.
Rayleigh-like instability in the ion-shaping of Au–Ag alloy nanoparticles embedded within a silica matrix (2011)

We have studied how spherical 23 ± 3 nm Au(45)Ag(55) nanoparticles embedded within a silica matrix transform into prolate nanorods and nanowires by irradiating them with swift heavy ions. Samples were irradiated at room temperature and normal incidence with 74 MeV Kr and 36 MeV S ions for fluences up to 1.0 × 10(15) cm(-2). We demonstrate the existence of two regimes: (i) below a critical fluence, ∼ 2.0 × 10(14) cm(-2), the transformation of the spherical nanoparticle into a nanorod is an individual process, i.e. each nanoparticle transforms into a single nanorod; (ii) for larger fluences the transformation from nanorod to nanowire becomes a collective process, i.e. the break up and dissolution of unstable nanorods contribute to the growth of long nanowires. The passage from the first to the second regime can be interpreted in terms of a Rayleigh-like instability under irradiation. The latter becomes active when the diameter of the nanowire approaches its saturation width under irradiation. Furthermore, we show that the composition of the alloy is only slightly modified during the ion-shaping process. Finally, the energy and the fluence thresholds for deformation and the deformation strain-rate are estimated.
Planar dielectrochromatography — A perspective technique (2003)

To simulate front displacement through porous media (TLC plates) the effect of the axisymmetric alternating electric fields on liquids confined in capillary tubes was studied. This electric field causes liquid displacement through capillary tubes with great velocity, the main action being on the liquid column meniscus. Capillary tubes were used to enable understanding of the flow phenomena which occur in porous media. It was observed that the displacement velocity of the liquids confined in capillary tubes depended on the magnitude of the alternating electric field, the electric properties (conductivity, permittivity) of the liquids, the frequency of the current, and the tube material.In normal TLC practice, migration of the mobile phase through the layer is controlled by capillary forces. The velocity and migration distance of the mobile-phase front in prous media can be increased by application of an external electric field, an effect called by us ‘dielectroosmotic flow’ (DEOF), because of its similarity with electrokinetic phenomena. DEOF is observed on different TLC plates and paper strips developed with non-polar and polar solvents. As a result the separation of some compounds was improved. This method is a hybrid of electric forced flow and classical TLC; we have named it ‘planar dielectrochromatography’ (PDEC).A horizontal chromatographic chamber has been constructed and has been used to investigate the principles of planar dielectrochromatography, specifically the increase in front velocity and the dielectrophoretic force generated at granule level on different ready-to-use plates.
HANDBOOK OF FIBER-REINFORCED CONCRETE. PRINCIPLES, PROPERTIES, DEVELOPMENTS AND APPLICATIONS (1990)

The state of the art of fiber-reinforced concrete systems is covered in this book. This book constitutes a contribution to the concrete literature during a period of dynamic growth of cement composite technology in the construction materials industry. The principles and modern theories predicting the role of fiber reinforcement in cement systems are introduced in a concise and logical manner. The latest developments and research on glass fiber-reinforced cement are presented in the context of behavioral mechanisms, matrix microstructure and fiber-matrix interface physics and chemistry. This methodology was also applied to cement composites containing polypropylene, polyethylene, polyamide, carbon, polyvinyl alcohol and numerous other fiber types.
Books (1984)

Journal Article Books Get access Manuel de Falla Suzanne Demarquez Translated by Salvator AttanasioNew York: Da Capo Press, Reprint, 1983 253 pages, $25.00 John Dowling John Dowling Search for other works by this author on: Oxford Academic Google Scholar The Opera Quarterly, Volume 2, Issue 1, Spring 1984, Pages 127–129, https://doi.org/10.1093/oq/2.1.127 Published: 01 March 1984
A Case of Early Neurosyphilis. (2017)

The initial manifestations of syphilis in this patient were posterior uveitis and pruritic skin plaques. His diagnosis should be appropriately classified as secondary syphilis with concomitant symptomatic early neurosyphilis, requiring 14 days of aqueous crystalline penicillin G. This type of presentation is not specific to immunocompromised populations and must be considered even in the general population. Making the diagnosis of early neurosyphilis, regardless of stage, is critical, as it necessitates a longer duration of treatment. Furthermore, clinicians should be reminded of the profound immunologic reaction, Jarisch-Herxheimer, which may occur when treating any treponemal disease.
ABEL trial: A phase II randomized trial adding bemiparin (B) to chemo-radiotherapy (CT-RT) in limited-stage small cell lung cancer (SCLC)—Final results. (2012)

7095 Background: Low molecular weight heparins (LMWH) could improve therapeutic outcomes in patients with advanced cancer. Heparin binding growth associated molecule is a member of growth factors involved in proliferation, angiogenesis and metastases in SCLC. LMWH associated with CT increase survival in cancer patients (Cochrane DB Systematic Reviews 2011). LMWH do not increase hemorrhagic events when used in neoplastic patients. Methods: Open randomized phase II multicentric trial to assess efficacy and safety of adding bemiparin to standard CT-RT in patients with SCLC with limited disease. CT: Cis/carboplatin + etoposide x 4-6 cycles. Concurrent early thoracic RT (45-50 Gy) and prophylactic cranial irradiation in case of response. Patients (p) were randomly allocated to addition of B at daily subcutaneous dose of 3.500 UI during 26 weeks. Primary end-point: progression free survival (PFS). Secondary end-points: response (RECIST), safety profile (CTC), venours thromboembolic (VTE) and hemorrhagic events incidence and overall survival (OS). Sample size 130 p. Preplanned interim analysis after inclusion 30 p. Results: From October-05 to January/10 39 p were included. Study was closed after interim analysis due to poor recruitment. 38 evaluable p. ITT analysis: 20 CR-RT + B vs 18 CT-RT. No significant disbalance in patient characteristics and prognostic factors. Median PFS 58.6 weeks (CT-RT+B) vs 38.8 w (CT-RT) (HR 2.576; Log-rank p=0,018). RR: 65% (CT-RT+B) vs 55% (CT-RT) (NS); Median OS 161.8 w (CT-RT+B) vs 49.3 w (CT-RT) (HR 2.96; Log-rank p=0,012). 2-year survival rate: 68.6% (CT-RT+B) vs 29.4% (CT-RT) (p=0,0042). Safety: G3-4 AE: 50% vs 67%; bleeding events: 10% vs 27% (NS); thrombocytopenia 15% vs 50% (p=0.024); VTE: 0 vs 22% (p=0.041). Conclusions: Addition of B (3.500 u/daily s.c. during 26 w) to CT-RT in SCLC with LD significantly increases PFS and OS. B does not increase hemorragic events and significantly reduces VTE. In spite of early closure of the trial due to poor accrual, these results warrants further research in this approach trying to improve current outcomes of SCLC. ClinicalTrials.gov Id: NCT00324558.
Degeneration of the Organ of Corti Following Intravenous Administration of Cisplatin (1991)

The development of acute morphological changes in the cochlea was studied in guinea pigs given one intravenous high-dose injection of cisplatin. In the light microscope three major stages of degeneration in the organ of Corti could be recognized: 1) an initial swelling of the Hensen's cells and protrusion of the Deiters' cells into the space of Nuel enclosing the outer hair cells, 2) a gradual degeneration of the outer hair cells together with a vacuolization in the region of the base of the inner hair cells, 3) a collapse of the Reissner's membrane and the entire organ of Corti with different degrees of damage to the inner hair cells. Sporadic bulging of the marginal cells of the stria vascularis into the endolymphatic space could be observed 4 days after injection.
Cisapride and Cystic Fibrosis (1989)

Santamaria, F.; Oggero, V.; Raia, V.; Salvatore, D.; Vittoria, L.; de Ritis, G. Author Information
FOOD-DRUG INTERACTIONS VIA HUMAN CYTOCHROME P450 3A (CYP3A) (2004)

Food-drug interactions have been reported to occur in various systems in the body. The causes of these interactions are mainly divided into pharmacodynamic and pharmacokinetic processes. Among these processes, drug metabolism plays a crucial role in drug interactions. Metabolic food-drug interactions occur when a certain food alters the activity of a drug-metabolizing enzyme, leading to a modulation of the pharmacokinetics of drugs metabolized by the enzyme. A variety of interactions have been documented so far. Foods consisting of complex chemical mixtures, such as fruits, alcoholic beverages, teas, and herbs, possess the ability to inhibit or induce the activity of drug-metabolizing enzymes. According to results obtained thus far, cytochrome P450 3A4 (CYP3A4) appears to be a key enzyme in food-drug interactions. For example, interactions of grapefruit juice with felodipine and cyclosporine, red wine with cyclosporine, and St John's wort with various medicines including cyclosporine, have been demonstrated. The results indicate the requirement of dosage adjustment to maintain drug concentrations within their therapeutic windows. The CYP3A4-related interaction by food components may be related to the high level of expression of CYP3A4 in the small intestine, as well as its broad substrate specificity, as CYP3A4 is responsible for the metabolism of more than 50% of clinical pharmaceuticals. This review article summarizes the findings obtained to date concerning food-drug interactions and their clinical implications. It seems likely that more information regarding such interactions will accumulate in the future, and awareness is necessary for achieving optimal drug therapy.
Doubly fed induction generator (DFIG) in wind turbine. modeling and power flow control (2005)

In this work, the doubly fed induction generator (DFIG) for wind energy conversion system is studied. First, the dq model of the wound rotor induction machine in rotor reference frame and then how it can be implemented in simulink for fast simulations. In order to control the power flowing between the stator of (DFIG) and the grid, a control law is synthesized using PI controllers. Simulation results have demonstrated its excellent performances, with stator flux orientation control (SFOC).
Inherently robust micro gyroscope actuated by parametric resonance (2008)

The sensitivity loss, commonly presented in micro gyroscopes based on harmonic oscillators [1], is overcome by using parametric resonance as an actuation mechanism. This operation has been analytically studied in IEEE- Sensors'05 [2] and preliminary dynamical characterization and experimental setup has been presented in IDETC/CIE- ASME'07 [3]. The device is fabricated using SOI process and in this paper we report complete rate table characterization including off-axis isolation, drift, hysteresis and noise of the micro gyroscope with an additional amplification stage.
Interleukin-1 receptor associated kinase 1/4 and bromodomain and extra-terminal inhibitions converge on NF-κB blockade and display synergistic antitumoral activity in activated B-cell subset of diffuse large B-cell lymphoma with <i>MYD88</i> L265P mutation (2021)

Not available.
Novel Impedance-Matching Method for Plasma Processing at Very High Frequency Band (1996)

The paper concerns a method of impedance matching between an rf generator and a plasma for material processing at the VHF band. Unlike the conventional methods for the case of low frequency, e.g. , 13.56 MHz, in this method, a transmission line and two variable capacitors are adopted and the use of inductors is avoided. The ranges of line length and capacitances are shown graphically and formulated for easy calculation using an electronic calculator. The efficiency of the matcher is derived, including the losses of the network elements. Experiments in an ECR plasma demonstrate that the theoretical derivations are valid within experimental error, that the method is effective up to 190 MHz with the rf-bias voltage independent of network parameters and a factor of 3 greater compared with direct connection, and that VHF-biasing increases ion energy without significant broadening of the ion energy distribution.
Single-Use System Integrity II: Characterization of Liquid Leakage Mechanisms (2020)

This study investigated the liquid leakage mechanism through microchannels in a flexible single-use packaging system composed of multilayer plastic film. Based on this study, a relationship between the maximum allowable leakage limit (MALL) and the loss of package integrity can be established under different use-case conditions. The MALL is defined as the greatest leak size that does not pose any risk to the product. A specifically designed liquid leak test was used to determine the leakage time, i.e., the time it takes for a package to show leakage. As a result, this method was able to determine the leak size for which no liquid leakage is observed after 30 days. This leak size varied between 2 µm and 10 µm and can be considered the MALL for liquid egress under different use-case conditions. This article also compared the MALL results of this liquid leak test with those of the microbial ingress test, showing a direct correlation between both tests. As test samples, an ethylene vinyl acetate multilayer film (300 µm thick) and a polyethylene multilayer film (400 µm thick) were cut into 50 mm patches. Before the patches were assembled in a filter holder to form a leak-tight seal, artificial leaks in sizes of 2 -25 µm were laser drilled into the center of each patch. The test units were filled aseptically with culture media and mounted vertically on the test setup. Various pressures were applied to each test unit to simulate the constraints that single-use systems may be subject to under real-world conditions. To detect the exact leakage time, electric circuits with timers were attached below each film patch. Microscopic investigations, including light microscopy and computed tomography, were used to interpret and understand the physics and geometries of the microchannels to explain any deviation from the expected results.
Inelastic neutron scattering studies of hydrogen uptake by a model hydrodesulphurization catalyst at high pressure (1982)

S. Vasudevan, J. M. Thomas, C. J. Wright and C. Sampson, J. Chem. Soc., Chem. Commun., 1982, 418 DOI: 10.1039/C39820000418
An ionization region model of the reactive Ar/O2high power impulse magnetron sputtering discharge (2016)

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