gebhart/patrepeval huggingface dataset:
A comparison of diethyldithiocarbamate and EDTA as antidotes for acute cadmium intoxication. (1982)

For mice which have been given the cadmium equivalent of CdCl2 X 2 1/2H2O at a level of 10 mg/kg, diethyldithiocarbamate (DDTC) administration at 500 mg/kg leads to a higher survival rate than is found with Na2CaEDTA under identical conditions. This occurs when the interval between administration of the cadmium salt and the antidote is either one or two hours. The surviving animals, however, are found to have appreciable levels of cadmium in their brain, liver and kidney when they were treated with DDTC, though their behavior appeared to be normal. The use of 50 mg/kg of DDTC after 2 hr in such cadmium poisoned mice also leads to a higher survival rate and reduced amounts of cadmium retained in the brain, liver and kidney. Unlike the other chelating agents which have been reported as useful in acute cadmium intoxication, DDTC appears to act by forming a lipid soluble complex which is largely immobilized in lipid containing tissues of the animal's body.
Preliminary Material (1988)

schillende redenen.Een moeilijke overgangsperiode is zonder kleerscheuren doorworsteld.
Weakly Supervised Classification of Vital Sign Alerts as Real or Artifact. (2022)

A significant proportion of clinical physiologic monitoring alarms are false. This often leads to alarm fatigue in clinical personnel, inevitably compromising patient safety. To combat this issue, researchers have attempted to build Machine Learning (ML) models capable of accurately adjudicating Vital Sign (VS) alerts raised at the bedside of hemodynamically monitored patients as real or artifact. Previous studies have utilized supervised ML techniques that require substantial amounts of hand-labeled data. However, manually harvesting such data can be costly, time-consuming, and mundane, and is a key factor limiting the widespread adoption of ML in healthcare (HC). Instead, we explore the use of multiple, individually imperfect heuristics to automatically assign probabilistic labels to unlabeled training data using weak supervision. Our weakly supervised models perform competitively with traditional supervised techniques and require less involvement from domain experts, demonstrating their use as efficient and practical alternatives to supervised learning in HC applications of ML.
Differential optical switching at subnanowatt input power (1989)

An operating technique for a differential optical switching device based on a set of parallel-connected pnpn structures is discussed. The differential function at subnanowatt input powers was demonstrated with AlGaAs/GaAs pnpn devices. The highly sensitive devices are promising for applications both to optical neural networks and to optical digital computing because of the low power consumption of the light emitting devices and the large fan-in/fan-out ratio ( approximately 10/sup 5/).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Rearrangements of 4-alkynylcyclobutenones. Annelated spiroepoxycyclohexadienones and quinones from 4-(1,5-alkadiynyl)-4-methoxy- or -hydroxycyclobutenones (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRearrangements of 4-alkynylcyclobutenones. Annelated spiroepoxycyclohexadienones and quinones from 4-(1,5-alkadiynyl)-4-methoxy- or -hydroxycyclobutenonesHaiji Xia and Harold W. MooreCite this: J. Org. Chem. 1992, 57, 14, 3765–3766Publication Date (Print):July 1, 1992Publication History Published online1 May 2002Published inissue 1 July 1992https://pubs.acs.org/doi/10.1021/jo00040a008https://doi.org/10.1021/jo00040a008research-articleACS PublicationsRequest reuse permissionsArticle Views343Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Smart transducer systems working in communication networks within the IEEE-1451 standard (2003)

We show our work developed on smart transducer systems controlled via communication network such as CAN or Ethernet. We have chosen the IEEE-1451 standard as a basic lines to fit. This normative tries to settle down a new concept in the way of working with transducers, simplifying and unifying the procedure and hardware needed. We have worked within the IEEE1451 standard, implementing complete nodes according to this normative. Each node includes two subsystems, a STIM and an NCAP.
Tolerance of a Knotted Near-Infrared Fluorescent Protein to Random Circular Permutation (2016)

Bacteriophytochrome photoreceptors (BphP) are knotted proteins that have been developed as near-infrared fluorescent protein (iRFP) reporters of gene expression. To explore how rearrangements in the peptides that interlace into the knot within the BphP photosensory core affect folding, we subjected iRFPs to random circular permutation using an improved transposase mutagenesis strategy and screened for variants that fluoresce. We identified 27 circularly permuted iRFPs that display biliverdin-dependent fluorescence in Escherichia coli. The variants with the brightest whole cell fluorescence initiated translation at residues near the domain linker and knot tails, although fluorescent variants that initiated translation within the PAS and GAF domains were discovered. Circularly permuted iRFPs retained sufficient cofactor affinity to fluoresce in tissue culture without the addition of biliverdin, and one variant displayed enhanced fluorescence when expressed in bacteria and tissue culture. This variant displayed a quantum yield similar to that of iRFPs but exhibited increased resistance to chemical denaturation, suggesting that the observed increase in the magnitude of the signal arose from more efficient protein maturation. These results show how the contact order of a knotted BphP can be altered without disrupting chromophore binding and fluorescence, an important step toward the creation of near-infrared biosensors with expanded chemical sensing functions for in vivo imaging.
Figure S6 from SWI/SNF Complex Mutations Promote Thyroid Tumor Progression and Insensitivity to Redifferentiation Therapies (2023)

&lt;p&gt;Effects of BrafV600E on thyroid differentiation.&lt;/p&gt;
Two-dimensionally parallel optical interconnects using VCSELs with an integrated lens (2008)

We propose multistage waveguide coupling scheme by using VCSELs with an integrated lens for onboard optical interconnection. We demonstrated the possibility of multistage coupling more than five stage and it indicates the higher-density parallel optical interconnection with a small footprint.
Drive assist system using stereo image recognition (2002)

A safety vehicle using an obstacle detection system with a stereo image sensor has been developed. The stereo image sensor was chosen as a more suitable sensor, compared to a laser radar or a millimeter wave radar. The matching method adopted for this stereo system is the small area based matching to yield a distance distribution image. The road shape and solids are recognized from the distance distribution image. This safety vehicle has three functions for the "avoidance stage" proposed in ASV (advanced safety vehicle) project as follows: a collision alarm system; an autonomous collision avoidance system; and a lane-keeping alarm system. Reduction rates by this safety vehicle for a rear-end collision and a collision encountered at a intersection were estimated. It was recognized that the system was greatly effective for both type of collisions.
A mouse bone marrow dosimetry model. (1998)

This work shows that, even for the lower mean beta energy-emitting radionuclide, such as 131I, accurate computation of the mouse bone marrow dose involves including both the energy loss from beta decays within the marrow and dose contributions from tissue surrounding the marrow.
MO131THE SHRUNKEN PORE SYNDROME IS ASSOCIATED WITH POOR PROGNOSIS AND LOWER QUALITY OF LIFE IN HEART FAILURE PATIENTS- THE HARVEST-MALMÖ STUDY (2021)

Abstract Background and Aims The cardiorenal syndrome was studied in heart failure (HF) patients with respect to the “Shrunken pore syndrome” (SPS) that is characterized by a difference in renal filtration between cystatin C and creatinine, resulting in a low eGFRcystatin C/eGFRcreatinine-ratio. Method 373 patients hospitalized for HF were retrieved from the HeARt and brain failure inVESTigation trial (HARVEST-Malmö). We used CKD-EPI formulas for estimated glomerular filtration rate (eGFR). Presence of SPS was defined as eGFRcystatinC ≤60% of eGFRcreatinine. In Cox regression multivariate models, associations between SPS, risk of death and risk of 30-day re-hospitalization were studied. Associations between SPS and impaired quality of life (QoL) were studied using multivariate logistic regressions. Results SPS was associated with all-cause mortality (124 events; hazard ratio (HR) 2.35; confidence interval (CI95%) 1.17-4.71; p=0.016 and with 30-day re-hospitalization (70 events; HR 1.82; CI95% 1.04-3.18; p=0.036). Analyses of QoL, based on a Kansas City Cardiomyopathy Questionnaire overall score &amp;lt;50, revealed that SPS was associated with increased risk of low health-related QoL (odds ratios (OR) 2.15 (CI95% 1.03-4.49; p=0.042). Conclusion The results of this observational study show for the first time an association between SPS and poor prognosis in HF. Further studies are needed to confirm the results in HF cohorts and experimental settings to identify pathophysiological mechanisms.
Controllable supramolecular structures and luminescent properties of unique trimeric Zn(ii) 8-hydroxyquinolinates tuned by functional substituents (2012)

We reported here the self-assembly of two supramolecular structures based on similar trimeric Zn(II) units that are built from novel 2-substituted 8-hydroxyquinoline ligands and coordination Zn(II) ions. The aggregation behavior of zinc salt and ligand in solution was investigated by a variety of techniques, including (1)H NMR, UV-vis and photoluminescence (PL). In the solid state, the supramolecular structures can be controlled by the substituted groups (-NO(2) and -F) via intermolecular interaction, such as π···π stacking, C-H···O, and C-F···F-C interactions. As a result, the two trimeric Zn(II) complexes exhibit disparate photophysical properties. The present research holds great promise in the development of novel multinuclear Zn(II) materials, and may contribute to the understanding of structure-property relationships.
Gut microbiota-derived tryptamine impairs insulin sensitivity (2022)

Summary Gut-microbiota plays a pivotal role in development of type 2 diabetes (T2D), yet the molecular mechanism remains elusive. Here, we show that tryptamine, a microbial metabolite of tryptophan, impairs glucose tolerance and insulin sensitivity. Tryptamine presents a higher level in monkeys with spontaneous diabetes and human with T2D and positively correlated with the glucose tolerance. In parallel, tryptamine level was suppressed by dietary fibers intervention in T2D subjects and negatively correlated with improvement of glucose tolerance. The inhibitory effect of tryptamine on insulin signaling as shown was dependent on a trace amine-associated receptor 1 (TAAR1)-extracellular signal-regulated kinase (ERK) signaling axis. Monoassociation of T2D-associated tryptamine-producing bacteria Ruminococcus gnavus impairs insulin sensitivity in pseudo germ-free mice. Our findings indicate gut microbiota-derived tryptamine contributes to the development of insulin resistance in T2D and may serve as a new target for intervention. Graphical Abstract
Wrought Titanium and Titanium Alloys (1990)

Abstract This article discusses the wrought product forms of titanium and titanium-base alloys, which include forgings and the typical mill products with tabulations for various specifications, and compares specifications for pure titanium, titanium alloys for mechanical, physical properties and chemical properties, including chemical composition, corrosion resistance, and chemical reactivity. The article discusses the effects of alloying elements in titanium alloys, and describes the classes of titanium alloys, namely, alpha alloys, alpha-beta alloys, and beta alloys. It also describes the typical applications of various titanium-base materials, and explains the crystal structure, effect of impurities, and microstructural constituents of titanium alloys. The article provides a brief description on the processing of wrought titanium alloys, including primary fabrication in which ingots are converted into general mill products and secondary fabrication (forging, extrusion, forming, machining, chemical milling and joining) of finished shapes from mill products and the heat treatment of titanium alloys.
Temporal structures in shell models (2001)

The intermittent dynamics of the turbulent Gledzer, Ohkitani, and Yamada shell-model is completely characterized by a single type of burstlike structure, which moves through the shells like a front. This temporal structure is described by the dynamics of the instantaneous configuration of the shell amplitudes, revealing an approximate chaotic attractor of the dynamics.
Time-series classification using mixed-state dynamic Bayesian networks (2003)

We present a novel mixed-state dynamic Bayesian network (DBN) framework for modeling and classifying time-series data such as object trajectories. A hidden Markov model (HMM) of discrete actions is coupled with a linear dynamical system (LDS) model of continuous trajectory motion. This combination allows us to model both the discrete and continuous causes of trajectories such as human gestures. The model is derived using a rich theoretical corpus from the Bayesian network literature. This allows us to use an approximate structured variational inference technique to solve the otherwise intractable inference of action and system states. Using the same DBN framework we show how to learn the mixed-state model parameters from data. Experiments show that with high statistical confidence the mixed-state DBNs perform favorably when compared to decoupled HMM/LDS models on the task of recognizing human gestures made with a computer mouse.
Oxazole Cyclopeptides for Chirality Transfer in C3‐Symmetric Octahedral Metal Complexes (2008)

Abstract A straightforward synthesis of C 3 ‐symmetric oxazole‐containing macrocyclic peptide scaffolds is presented. This type of macrocycles bears three functional groups on the oxazole rings, which allows fixing of various receptor arms on them in an easy manner. The chiral backbone of the macrocycle proved to be a powerful tool for chirality induction, thus predetermining the configuration of helically coordinated metal centres. The diastereoselective formation of Co II , Ni II , Cu II and Zn II complexes with tripodal bipyridyl ligand 4 was proved by UV‐ and CD‐absorption spectrophotometric titration experiments.(© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2008)
Relative campaign during the International Comparison of Absolute Gravimeters ICAG-2005 and the strategy of data treatment combined with the absolute results (2007)

peer reviewed
Gene expression analysis of peripheral T-cell lymphoma not otherwise specified reveals two distinct subgroups and recurrent PDGFR-alpha deregulation (2009)

Peripheral T-cell lymphomas (PTCLs) represent approximately 12% of lymphoid neoplasms.Their incidence varies in different countries and races, being higher in HTLV-1 endemic areas (Asia, Caribbean basin and some parts of the United States).PTCLs are a heterogeneous group of tumours that in the REAL/WHO Classification are roughly subdivided into specified and unspecified (or not otherwise specified, NOS) forms. In particular, the latter – corresponding to about 50% of T-cell lymphomas – cannot be further classified on the basis of morphology, phenotype and conventional molecular studies. Immunohistochemistry does generally show T-cell associated molecule expression, although the phenotypic profile is aberrant in about 80% of cases, CD5 and CD7 being the most frequently defective antigens.
A monolithic 3 to 40 GHz HEMT distributed amplifier (2003)

A monolithic 3-to-40-GHz distributed amplifier has been developed using 0.25- mu m HEMTs (high-electron-mobility transistors) with mushroom gate profile, as an active device. This amplifier consists of five 0.25- mu m HEMTs with variable gate widths and on-chip biasing circuit. The chip size is 2.3*0.8 mm. A measured gain of 8 dB from 3 to 33 GHz and a measured midband noise figure of 3 dB from 10 to 30 GHz were achieved. The authors note that these are the best reported results for an amplifier over this bandwidth.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Fig. S6 from Chemotherapy-Induced IL34 Enhances Immunosuppression by Tumor-Associated Macrophages and Mediates Survival of Chemoresistant Lung Cancer Cells (2023)

&lt;p&gt;IL-34 expression in cancers&lt;/p&gt;
Total Syntheses of Leuconoxine, Leuconodine B, and Melodinine E by Oxidative Cyclic Aminal Formation and Diastereoselective Ring-Closing Metathesis (2014)

Total syntheses of leuconodine B, melodinine E, and leuconoxine were accomplished via a divergent route. The [5.5.6.6]diazafenestrane skeleton was constructed from an indole-3-acetamide derivative via DMDO oxidation to hydroxylindolenine, TMSOTf/2,6-lutidine mediated cyclic aminal formation, and diastereoseletive ring-closing metathesis of a triene derivative.
Coupling of fully automated chip electrospray to Fourier transform ion cyclotron resonance mass spectrometry for high‐performance glycoscreening and sequencing (2004)

The NanoMate robot has been coupled to a Fourier transform ion cyclotron resonance (FTICR) mass spectrometer at 9.4 T and implemented for the first time for complex carbohydrate analysis. It was optimized in the negative ion mode to achieve automated sample delivery on the chip along with increased sensitivity, ultra-high resolution and accurate mass determination. A novel bracket has been designed to allow a reliable mounting of the NanoMate to the Apollo electrospray ionization (ESI) source of an APEX II instrument. The notably higher efficiency of ionization for compositional mapping of complex mixtures and feasibility for fragmentation analysis of components by sustained off-resonance irradiation collision-induced tandem mass spectrometry (SORI-CID MS2) has been demonstrated on a glycoconjugate mixture containing O-glycosylated sialylated peptides from urine of a patient suffering from a hereditary N-acetylhexosaminidase deficiency (Schindler's disease), previously analyzed by capillary-based nanoESI-FTICRMS, and of a healthy control person. Due to its potential to generate highly charged ionic species, reduce the in-source fragmentation, increase sensitivity, reproducibility and ionization efficiency, along with the ability to generate a sustained and constant electrospray, this method can be considered as a new platform for advanced glycomics.
Chemical stability enhancement of crown ether grafted sulfonated poly(arylene ether ketone) fuel cell membrane by cerium ion fixation (2018)

ABSTRACT In operation of polymer electrolyte membrane fuel cell or direct methanol fuel cell, ·OH radicals are the major cause for the degradation of polymer electrolyte membrane. In order to enhance its antioxidation stability, cerium ion (Ce 3+ , CE), an ·OH radical quencher, is introduced to membrane, as it converts the ·OH radicals into inactive chemicals. In this study, aminoethyl‐15‐crown‐5 (CRE) is grafted on the sulfonated poly(arylene ether ketone) (SPAEK) to prevent the migration of CE ions from the membrane for long‐term antioxidation stability, as CRE forms a coordination complex with CE. The chemical and physical structures of the CRE grafted SPAEK are examined using proton nuclear magnetic resonance, energy dispersive X‐ray, and small‐angle X‐ray scattering spectroscopy. The physical properties of the CRE grafted SPAEK membrane are investigated and compared with those of the CRE blended and CE blended ones. While the grafting of CRE does not significantly affect the thermal and mechanical and water uptake behaviors of membranes, it leads to a significant improvement of antidegradation effect compared with other blend systems according to Fenton's test. The proton conductivity decreases with addition of CE but its effect is lessened by introduction of CRE. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019 , 57 , 101–109
ChemInform Abstract: Transannular Interaction in 3‐Heterobicyclo(3.3.0)octanes, Implications for the Mechanism of Biotin Action. (1989)

Abstract Starting with the bicyclic ketones (I), which are dideaza analogues of biotin, the endo/exo‐tosylates (V) and (VI), the endo‐tertiary alcohols (VIII), and the exo‐chlorides (IX) are prepared by standard procedures.
1700: VA ECMO FOR A PEDIATRIC PATIENT WITH WORSENING HEPATOPULMONARY SYNDROME FOLLOWING LIVER TRANSPLANT (2016)

Copyright © 2016 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved.
Anin vitromodel of human neocortical development using pluripotent stem cells: cocaine-induced cytoarchitectural alterations (2014)

Neocortical development involves ordered specification of forebrain cortical progenitors to various neuronal subtypes, ultimately forming the layered cortical structure. Modeling of this process using human pluripotent stem cells (hPSCs) would enable mechanistic studies of human neocortical development, while providing new avenues for exploration of developmental neocortical abnormalities. Here, we show that preserving hPSCs aggregates - allowing embryoid body formation - while adding basic fibroblast growth factor (bFGF) during neuroepithelial development generates neural rosettes showing dorsal forebrain identity, including Mash1(+) dorsal telencephalic GABAergic progenitors. Structures that mirrored the organization of the cerebral cortex formed after rosettes were seeded and cultured for 3 weeks in the presence of FGF18, BDNF and NT3. Neurons migrated along radial glia scaffolding, with deep-layer CTIP2(+) cortical neurons appearing after 1 week and upper-layer SATB2(+) cortical neurons forming during the second and third weeks. At the end of differentiation, these structures contained both glutamatergic and GABAergic neurons, with glutamatergic neurons being most abundant. Thus, this differentiation protocol generated an hPSC-based model that exhibits temporal patterning and a neuronal subtype ratio similar to that of the developing human neocortex. This model was used to examine the effects of cocaine during neocorticogenesis. Cocaine caused premature neuronal differentiation and enhanced neurogenesis of various cortical neuronal subtypes. These cocaine-induced changes were inhibited by the cytochrome P450 inhibitor cimetidine. This in vitro model enables mechanistic studies of neocorticogenesis, and can be used to examine the mechanisms through which cocaine alters the development of the human neocortex.