gebhart/patrepeval huggingface dataset:
A Mixed Reality Telepresence System for Collaborative Space Operation (2016)

This paper presents a mixed reality (MR) system that results from the integration of a telepresence system and an application to improve collaborative space exploration. The system combines free viewpoint video with immersive projection technology to support nonverbal communication (NVC), including eye gaze, interpersonal distance, and facial expression. Importantly, these features can be interpreted together as people move around the simulation, maintaining a natural social distance. The application is a simulation of Mars, within which the collaborators must come to agreement over; for example, where the Rover should land and go. The first contribution is the creation of an MR system supporting contextualization of NVC. Two technological contributions are prototyping a technique to subtract a person from a background that may contain physical objects and/or moving images and a lightweight texturing method for multiview rendering, which provides balance in terms of visual and temporal quality. A practical contribution is the demonstration of pragmatic approaches to sharing space between display systems of distinct levels of immersion. A research tool contribution is a system that allows comparison of conventional authored and video-based reconstructed avatars, within an environment that encourages exploration and social interaction. Aspects of system quality, including the communication of facial expression and end-to-end latency are reported.
Automatic dialog acts recognition based on sentence structure (2013)

This paper deals with automatic dialog acts (DAs) recognition in Czech. Our work focuses on two applications: a multimodal reservation system and an animated talking head for hearing-impaired people. In that context, we consider the following DAs: statements, orders, investigation questions and other questions. The main goal of this paper is to propose, implement and evaluate new approaches to automatic DAs recognition based on sentence structure and prosody. Our system is tested on a Czech corpus that simulates a task of train tickets reservation. With lexical-only information, the classification accuracy is 91 %. We proposed two methods to include sentence structure information, which respectively give 94 % and 95 %. When prosodic information is further considered, the recognition accuracy reaches 96 %. 1.
Caloric Restriction Stimulates Revascularization in Response to Ischemia via Adiponectin-mediated Activation of Endothelial Nitric-oxide Synthase (2008)

Caloric restriction (CR) can extend longevity and modulate the features of obesity-related metabolic and vascular diseases. However, the functional roles of CR in regulation of revascularization in response to ischemia have not been examined. Here we investigated whether CR modulates vascular response by employing a murine hindlimb ischemia model. Wild-type (WT) mice were randomly divided into two groups that were fed either ad libitum (AL) or CR (65% of the diet consumption of AL). Four weeks later, mice were subjected to unilateral hindlimb ischemic surgery. Body weight of WT mice fed CR (CR-WT) was decreased by 26% compared with WT mice fed AL (AL-WT). Revascularization of ischemic hindlimb relative to the contralateral limb was accelerated in CR-WT compared with AL-WT as evaluated by laser Doppler blood flow and capillary density analyses. CR-WT mice had significantly higher plasma levels of the fat-derived hormone adiponectin compared with AL-WT mice. In contrast to WT mice, CR did not affect the revascularization of ischemic limbs of adiponectin-deficient (APN-KO) mice. CR stimulated the phosphorylation of endothelial nitric-oxide synthase (eNOS) in the ischemic limbs of WT mice. CR increased plasma adiponectin levels in eNOS-KO mice but did not stimulate limb perfusion in this strain. CR-WT mice showed enhanced phosphorylation of AMP-activated protein kinase (AMPK) in ischemic muscle, and administration of AMPK inhibitor compound C abolished CR-induced increase in limb perfusion and eNOS phosphorylation in WT mice. Our observations indicate that CR can promote revascularization in response to tissue ischemia via an AMPK-eNOS-dependent mechanism that is mediated by adiponectin.
[Acute myelogenous leukemia with diabetes insipidus without desmopression administration by anti-leukemic chemotherapy]. (1995)

We report a case of AML with diabetes insipidus (DI). A 68-year-old female was admitted to our hospital because of fever and leukocytosis. The WBC was 197,000/microliter with 98% blasts positive for myeloperoxidase, CD33, CD34 and HLA-DR. While, on admission, urine volume was more than 6 liters daily. Blood vasopressin level was 0.3 microgram/ml. The patient was diagnosed as having AML with DI. By chemotherapy consisting of BHAC, DNR, 6-MP and PSL and intrathecal administration of AraC, MTX and PSL, and nasal drip of DDAVP, complete remission was attained and the urine volume was reduced to normal. Finally DDAVP became unnecessary. Although the exact cause of DI cannot be ascertained, rapid increase of leukemic blasts and leukostasis in small vessels might be associated with hypothalamus-pituitary system damage. Reportedly, DI is a rare complication of leukemia and administration of DDAVP could be halted in only two patients with leukemia and DI.
Attribute-Based Encryption for Fine-Grained Access Control of Encrypted Data. (2006)

As more sensitive data is shared and stored by third-party sites on the Internet, there will be a need to encrypt data stored at these sites. One drawback of encrypting data, is that it can be selectively shared only at a coarse-grained level (i.e., giving another party your private key). We develop a new cryptosystem for fine-grained sharing of encrypted data that we call Key-Policy Attribute-Based Encryption (KP-ABE). In our cryptosystem, ciphertexts are labeled with sets of attributes and private keys are associated with access structures that control which ciphertexts a user is able to decrypt. We demonstrate the applicability of our construction to sharing of audit-log information and broadcast encryption. Our construction supports delegation of private keys which subsumes Hierarchical Identity-Based Encryption (HIBE). E.3 [Data En-
Effects of urinary trypsin inhibitor on the invasion of reconstituted basement membranes by ovarian cancer cells (1994)

Using the human ovarian cancer cell line HOC-1, we investigated the effects of urinary trypsin inhibitor (UTI) purified from human urine and its related synthetic peptides on the invasive potential of cancer cells in an in vitro assay. Invasiveness of tumor cells was determined using a modified Boyden chamber and a reconstituted basement membrane Matrigel. Three peptides (peptide 1, peptide 2, and peptide 3), representing sequences within UTI, were synthesized. HOC-1 cells showed detectable and reproducible levels of expression of surface urokinase-type plasminogen activator (uPA) and plasminogen/plasmin by cell ELISAs and enzyme assays. UTI was found to strongly inhibit plasmin and human leukocyte elastase (HLE). Peptide 2 and peptide 3 specifically inhibit HLE and plasmin activity respectively. Peptide 1 has essentially no inhibitory activity. Treatment with UTI and peptide 3 reduces the incidence of invasion, whereas peptide 1 and peptide 2 do not affect invasion. The inhibitory effect on cell invasion is dose-dependent. The proteolytic enzyme plasmin may be involved in human ovarian cancer invasion in extracellular matrix degradation, and the use of UTI and peptide 3 that inhibits plasmin specifically reduces invasion by tumor cells.
Genome-wide association study identifies HLA-A*3101 allele as a genetic risk factor for carbamazepine-induced cutaneous adverse drug reactions in Japanese population (2010)

An anticonvulsant, carbamazepine (CBZ), is known to show incidences of cutaneous adverse drug reactions (cADRs) including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and drug-induced hypersensitivity syndrome (DIHS). To identify a gene(s) susceptible to CBZ-induced cADRs, we conducted a genome-wide association study (GWAS) in 53 subjects with the CBZ-induced cADRs, including SJS, TEN and DIHS, and 882 subjects of a general population in Japan. Among the single nucleotide polymorphisms (SNPs) analyzed in the GWAS, 12 SNPs showed significant association with CBZ-induced cADRs, and rs1633021 showed the smallest P-value for association with CBZ-induced cADRs (P = 1.18 × 10⁻¹³). These SNPs were located within a 430 kb linkage disequilibrium block on chromosome 6p21.33, including the HLA-A locus. Thus, we genotyped the individual HLA-A alleles in 61 cases and 376 patients who showed no cADRs by administration of CBZ (CBZ-tolerant controls) and found that HLA-A*3101 was present in 60.7% (37/61) of the patients with CBZ-induced cADRs, but in only 12.5% (47/376) of the CBZ-tolerant controls (odds ratio = 10.8, 95% confidence interval 5.9-19.6, P = 3.64 × 10⁻¹⁵), implying that this allele has the 60.7% sensitivity and 87.5% specificity when we apply HLA-A*3101 as a risk predictor for CBZ-induced cADRs. Although DIHS is clinically distinguished from SJS and TEN, our data presented here have indicated that they share a common genetic factor as well as a common pathophysiological mechanism. Our findings should provide useful information for making a decision of individualized medication of anticonvulsants.
Desulfurization with Raney Nickel. II. Sulfonamides1,2 (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDesulfurization with Raney Nickel. II. Sulfonamides1,2George R. Pettit and Raymond E. KadunceCite this: J. Org. Chem. 1962, 27, 12, 4566–4570Publication Date (Print):December 1, 1962Publication History Published online1 May 2002Published inissue 1 December 1962https://pubs.acs.org/doi/10.1021/jo01059a106https://doi.org/10.1021/jo01059a106research-articleACS PublicationsRequest reuse permissionsArticle Views1075Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Folding‐induced Fluorescence Enhancement in a Series of Merocyanine Hetero‐Folda‐Trimers (2021)

Abstract Many dyes suffer from fast non‐radiative decay pathways, thereby showing only short‐lived excited states and weak photoluminescence. Here we show a pronounced fluorescence enhancement for a weakly fluorescent merocyanine (MC) dye by being co‐facially stacked to other dyes in hetero‐folda‐trimer architectures. By means of fluorescence spectroscopy (lifetime, quantum yield) the fluorescence enhancement was explained by the rigidification of the emitting chromophore in the defined foldamer architecture and the presence of a non‐forbidden lowest exciton state in H‐coupled hetero‐aggregates. This folding‐induced fluorescence enhancement (FIFE) for specific sequences of π‐stacked dyes points at a viable strategy toward improved fluorophores that relates to the approach used by nature in the green fluorescent protein (GFP).
A DWT-DFT composite watermarking scheme robust to both affine transform and JPEG compression (2003)

Robustness is a crucially important issue in watermarking. Robustness against geometric distortion and JPEG compression at the same time with blind extraction remains especially challenging. A blind discrete wavelet transform-discrete Fourier transform (DWT-DFT) composite image watermarking algorithm that is robust against both affine transformation and JPEG compression is proposed. The algorithm improves robustness by using a new embedding strategy, watermark structure, 2D interleaving, and synchronization technique. A spread-spectrum-based informative watermark with a training sequence is embedded in the coefficients of the LL subband in the DWT domain while a template is embedded in the middle frequency components in the DFT domain. In watermark extraction, we first detect the template in a possibly corrupted watermarked image to obtain the parameters of an affine transform and convert the image back to its original shape. Then, we perform translation registration using the training sequence embedded in the DWT domain, and, finally, extract the informative watermark. Experimental work demonstrates that the proposed algorithm generates a more robust watermark than other reported watermarking algorithms. Specifically it is robust simultaneously against almost all affine transform related testing functions in StirMark 3.1 and JPEG compression with quality factor as low as 10. While the approach is presented for gray-level images, it can also be applied to color images and video sequences.
In Vivo Quantitative Understanding of PEGylated Liposome’s Influence on Brain Delivery of Diphenhydramine (2018)

Despite the promising features of liposomes as brain drug delivery vehicles, it remains uncertain how they influence the brain uptake in vivo. In order to gain a better fundamental understanding of the interaction between liposomes and the blood-brain barrier (BBB), it is indispensable to test if liposomes affect drugs with different BBB transport properties (active influx or efflux) differently. The aim of this study was to quantitatively evaluate how PEGylated (PEG) liposomes influence brain delivery of diphenhydramine (DPH), a drug with active influx at the BBB, in rats. The brain uptake of DPH after 30 min intravenous infusion of free DPH, PEG liposomal DPH, or free DPH + empty PEG liposomes was compared by determining the unbound DPH concentrations in brain interstitial fluid and plasma with microdialysis. Regular blood samples were taken to measure total DPH concentrations in plasma. Free DPH was actively taken up into the brain time-dependently, with higher uptake at early time points followed by an unbound brain-to-plasma exposure ratio ( K<sub>p,uu</sub>) of 3.0. The encapsulation in PEG liposomes significantly decreased brain uptake of DPH, with a reduction of K<sub>p,uu</sub> to 1.5 ( p < 0.05). When empty PEG liposomes were coadministered with free drug, DPH brain uptake had a tendency to decrease ( K<sub>p,uu</sub> 2.3), and DPH was found to bind to the liposomes. This study showed that PEG liposomes decreased the brain delivery of DPH in a complex manner, contributing to the understanding of the intricate interactions between drug, liposomes, and the BBB.
Nerve Agent Analogues That Produce Authentic Soman, Sarin, Tabun, and Cyclohexyl Methylphosphonate-Modified Human Butyrylcholinesterase (2009)

The goal was to test 14 nerve agent model compounds of soman, sarin, tabun, and cyclohexyl methylphosphonofluoridate (GF) for their suitability as substitutes for true nerve agents. We wanted to know whether the model compounds would form the identical covalent adduct with human butyrylcholinesterase that is produced by reaction with true nerve agents. Nerve agent model compounds containing thiocholine or thiomethyl in place of fluorine or cyanide were synthesized as Sp and Rp stereoisomers. Purified human butyrylcholinesterase was treated with a 45-fold molar excess of nerve agent analogue at pH 7.4 for 17 h at 21 degrees C. The protein was denatured by boiling and was digested with trypsin. Aged and nonaged active site peptide adducts were quantified by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry of the tryptic digest mixture. The active site peptides were isolated by HPLC and analyzed by MALDI-TOF-TOF mass spectrometry. Serine 198 of butyrylcholinesterase was covalently modified by all 14 compounds. Thiocholine was the leaving group in all compounds that had thiocholine in place of fluorine or cyanide. Thiomethyl was the leaving group in the GF thiomethyl compounds. However, sarin thiomethyl compounds released either thiomethyl or isopropyl, while soman thiomethyl compounds released either thiomethyl or pinacolyl. Thiocholine compounds reacted more rapidly with butyrylcholinesterase than thiomethyl compounds. Labeling with the model compounds resulted in aged adducts that had lost the O-alkyl group (O-ethyl for tabun, O-cyclohexyl for GF, isopropyl for sarin, and pinacolyl for soman) in addition to the thiocholine or thiomethyl group. The nerve agent model compounds containing thiocholine and the GF thiomethyl analogue were found to be suitable substitutes for true soman, sarin, tabun, and GF in terms of the adduct that they produced with human butyrylcholinesterase. However, the soman and sarin thiomethyl compounds yielded two types of adducts, one of which was thiomethyl phosphonate, a modification not found after treatment with authentic soman and sarin.
Light-narrowed optically pumpedMxmagnetometer with a miniaturized Cs cell (2011)

We demonstrate a way of operating an optically pumped magnetometer with miniaturized cesium cell using the light-narrowing effect. The magnetometer setup shows improvement of shot-noise-limited sensitivity ($42\phantom{\rule{0.16em}{0ex}}\mathrm{fT}/\sqrt{\mathrm{Hz}}$ in a cell of only $9.3\phantom{\rule{0.16em}{0ex}}{\mathrm{mm}}^{3}$ volume) due to the suppression of spin-exchange relaxation to a large extent and the use of a strikingly increased fraction of alkali-metal atoms for signal generation, working even in $\ensuremath{\mu}\mathrm{T}$ magnetic fields, by using only a single high-intensity laser beam both for pumping and probing of atomic spins.
Isolation and Identification of Salt-Tolerant Mangrove Endophyte from Red Sea Coast Jeddah, Saudi Arabia (2023)

The aim of the study was to isolate and identify the most salt-tolerant endophytic bacteria from the mangrove plants ( Avicennia marina ) from the Red Sea Jeddah coastal region. In total, 21 endophytic bacteria were isolated from various parts of Avicennia marina cultured under various salt concentrations in laboratory conditions. Out of 21 endophytes, one isolate was selected based on its salt tolerance capacity, the isolate was identified as Bacillus halotolerans using 16S rRNA sequencing. The nucleotide sequence has been deposited under accession number MT858957. Bacillus halotolerans ymk 021 grows under high salinity and temperature. In response to high salinity stress (550 mM) mung bean ( Vigna radiata L.) treated with B. halotolerans ymk021 showed significant results in morphological characteristics like fresh root and shoot weight, dry root and shoot weight, and root and shoot length. The ability of this salt-tolerant bacterial endophyte to produce antioxidants in plant may also resolve the major issue of oxidative damage during salinity stress. It may produce antibiotics, essential industrial enzymes too.
Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions (2023)

Inflammation in the central nervous system can impair the function of neuronal mitochondria and contributes to axon degeneration in the common neuroinflammatory disease multiple sclerosis (MS). Here we combine cell-type-specific mitochondrial proteomics with in vivo biosensor imaging to dissect how inflammation alters the molecular composition and functional capacity of neuronal mitochondria. We show that neuroinflammatory lesions in the mouse spinal cord cause widespread and persisting axonal ATP deficiency, which precedes mitochondrial oxidation and calcium overload. This axonal energy deficiency is associated with impaired electron transport chain function, but also an upstream imbalance of tricarboxylic acid (TCA) cycle enzymes, with several, including key rate-limiting, enzymes being depleted in neuronal mitochondria in experimental models and in MS lesions. Notably, viral overexpression of individual TCA enzymes can ameliorate the axonal energy deficits in neuroinflammatory lesions, suggesting that TCA cycle dysfunction in MS may be amendable to therapy.
Synthesis, Crystal Structure, and Electrochemical Properties of Li<sub>1.2+</sub><i><sub>x</sub></i>Mn<sub>0.3</sub>Co<sub>0.2</sub>Ni<sub>0.3</sub>O<sub>2</sub> (<i>x</i> > 0) for Lithium-ion Battery Cathodes (2015)

Li1.2+xMn0.3Co0.2Ni0.3O2 (x = 0, 0.2, 0.4) with a Li-rich layered rock salt type structure were synthesized by a high-pressure method. Rietveld analysis using neutron diffraction data elucidated that the Li atoms were located at the octahedral sites in the Li and transitional metal (TM) layers. Furthermore, additional Li was detected at the tetrahedral site in the TM layer for the x = 0.4 sample. The tetrahedral Li caused vacancies at the neighboring TM sites and a structural distortion of the (Li,M)O6 octahedra. The x = 0.4 sample exhibited larger and smaller charge and discharge capacities of 388 and 135 mAh g−1 at the first cycle, respectively, than the x = 0.2 sample (296 and 151 mAh g−1). The structural modification caused by the introduction of the tetragonal Li affects the initial activation process of the Li-rich layered rock salt type electrodes.
Human Mitogen-activated Protein Kinase Kinase 7 (MKK7) Is a Highly Conserved c-Jun N-terminal Kinase/Stress-activated Protein Kinase (JNK/SAPK) Activated by Environmental Stresses and Physiological Stimuli (1998)

We report the cloning of a novel human activator of c-Jun N-terminal kinase (JNK), mitogen-activated protein kinase kinase 7 (MKK7). The mRNA for MKK7 is widely expressed in humans and mice and encodes a 47-kDa protein (419 amino acids), as determined by immunoblotting endogenous MKK7 with an antibody raised against its N terminus. The kinase domain of MKK7 is closely related to a Drosophila JNK kinase dHep (69% identity) and to a newly identified ortholog from Caenorhabditis elegans (54% identity), and was more distantly related to MKK4, MKK3, and MKK6. MKK7 phosphorylated and activated JNK1 but failed to activate p38 MAPK in co-expression studies. In hematopoietic cells, endogenous MKK7 was activated by treatment with the growth factor interleukin-3 (but not interleukin-4), or by ligation of CD40, the B-cell antigen receptor, or the receptor for the Fc fragment of immunoglobulin. MKK7 was also activated when cells were exposed to heat, UV irradiation, anisomycin, hyperosmolarity or the pro-inflammatory cytokine tumor necrosis factor-alpha. Co-expression of constitutively active mutants of RAS, RAC, or CDC42 in HeLa epithelial cells or of RAC or CDC42 in Ba/F3 factor-dependent hematopoietic cells also activated MKK7, suggesting that MKK7 will be involved in many physiological pathways.
Pharmacokinetic and pharmacodynamic modelling of the novel human granulocyte colony‐stimulating factor derivative Maxy‐G34 and pegfilgrastim in rats (2009)

Maxy-G34 is a highly potent drug for stimulation of neutrophil production in rats. By our modelling approach, we quantified differences between Maxy-G34 and pegfilgrastim, related to pharmacokinetic parameters. Model simulations can be used to estimate optimal dosing and timing options in the present preclinical rat model.