gebhart/patrepeval huggingface dataset:
Effects of bedtime periocular and posterior cervical cutaneous warming on sleep status in adult male subjects: a preliminary study (2017)

Appropriate warming of the periocular or posterior cervical skin has been reported to induce autonomic or mental relaxation in humans. To clarify the effects of cutaneous warming on human sleep, eight male subjects with mild sleep difficulties were asked to try three experimental conditions at home, each lasting for 5 days, in a cross-over manner: warming of the periocular skin with a warming device for 10 min before habitual bedtime, warming of the posterior cervical skin with a warming device for 30 min before habitual bedtime, and no treatment as a control. The warming device had a heat- and steam-generating sheet that allowed warming of the skin to 40 °C through a chemical reaction with iron. Electroencephalograms (EEGs) were recorded during nocturnal sleep using an ambulatory EEG device and subjected to spectral analysis. All the participants reported their sleep status using a visual analog scale. We found that warming of the periocular or posterior cervical skin significantly improved subjective sleep status relative to the control. The EEG delta power density in the first 90 min of the sleep episode was significantly increased under both warming of the periocular or posterior cervical skin relative to the control. These results suggest that warming of appropriate skin regions may have favorable effects on subjective and objective sleep quality.
Data from Interferon-α Suppresses cAMP to Disarm Human Regulatory T Cells (2023)

&lt;div&gt;Abstract&lt;p&gt;IFN-α is an antineoplastic agent in the treatment of several solid and hematologic malignancies that exerts strong immune- and autoimmune-stimulating activity. However, the mechanisms of immune activation by IFN-α remain incompletely understood, particularly with regard to CD4&lt;sup&gt;+&lt;/sup&gt;CD25&lt;sup&gt;high&lt;/sup&gt;Foxp&lt;sup&gt;+&lt;/sup&gt; regulatory T cells (Treg). Here, we show that IFN-α deactivates the suppressive function of human Treg by downregulating their intracellular cAMP level. IFN-α–mediated Treg inactivation increased CD4&lt;sup&gt;+&lt;/sup&gt; effector T-cell activation and natural killer cell tumor cytotoxicity. Mechanistically, repression of cAMP in Treg was caused by IFN-α–induced MAP–ERK kinase (MEK)/extracellular signal-regulated kinase (ERK)–mediated phosphodiesterase 4 (PDE4) activation and accompanied by downregulation of IFN receptor (IFNAR)-2 and negative regulation of T-cell receptor signaling. IFN-α did not affect the anergic state, cytokine production, Foxp3 expression, or methylation state of the Treg-specific demethylated region (TSDR) within the &lt;i&gt;FOXP3&lt;/i&gt; locus associated with a stable imprinted phenotype of human Treg. Abrogated protection by IFN-α–treated Treg in a humanized mouse model of xenogeneic graft-versus-host disease confirmed IFN-α–dependent regulation of Treg activity &lt;i&gt;in vivo&lt;/i&gt;. Collectively, the present study unravels Treg inactivation as a novel IFN-α activity that provides a conceivable explanation for the immune-promoting effect and induction of autoimmunity by IFN-α treatment in patients with cancer and suggests IFN-α for concomitant Treg blockade in the context of therapeutic vaccination against tumor antigens. &lt;i&gt;Cancer Res; 73(18); 5647–56. ©2013 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Bulk semiconductor saturable absorber for a NaCl color center laser (1990)

Using bulk InGaAsP as a saturable absorber we have passively mode locked a NaCl color center laser to produce transform-limited, pedestal-free pulses near 1.6 μm as short as 197 fs with up to 4.2 kW peak power. Our results simplify the saturable absorber material requirements and prove that excitons are not required for generating subpicosecond pulses. By comparing a dozen samples we find that a minimum band-edge absorbance of 40% is required to generate subpicosecond pulses, although details of the band edge are not critical. In addition, we find stable mode locking always occurs on the long-wavelength side of the laser gain peak.
Brief Overview of Functionally Graded NiTi‐Based Shape Memory Alloys (2023)

Shape memory alloys (SMAs) are kinds of smart materials that have superior properties such as shape memory effect and superelasticity, which have the most potential applications in various fields, especially in aerospace, naval, automobile and biomedicine industries, etc. Nevertheless, the inherent natures of shape memory alloys are characterized by the smaller transformation temperature intervals and transformation stress intervals, which make the devices have poor control ability. To achieve the accurate controllability for progressive movement, creating functionally graded shape memory alloys has been adopted. Herein, the classification, fabrications, microstructural features, and performances of functionally graded shape memory alloys are reviewed. For comparison, the creation of various gradients in shape memory alloys can widen the transformation temperature intervals and transformation stress intervals to some extent. In addition, the formation of the compositional, microstructural, or geometrical gradient also contributes to the generation of excellent performances such as the four‐way shape memory effect, higher strength, and larger temperature window for the stress‐assisted two‐way shape memory effect, etc. Such superior functions promote a wider application range of shape memory alloys.
Urinary lithogenesis risk tests: Comparison of a commercial kit and a laboratory prototype test (2011)

The new commercial NefroPlus test offers fast and cheap evaluation of the overall risk of development of urinary calcium-containing calculi.
A uniparental isodisomy event introducing homozygous pathogenic variants drives a multisystem metabolic disorder (2019)

Uniparental isodisomy (UPiD) is a rare genetic event that occurs when two identical copies of a single chromosome are inherited from one parent. Here we report a patient with a severe, multisystem metabolic disorder who inherited two copies of Chromosome 12 from her father. He was a heterozygous carrier of a variant in the muscle-specific enzyme 6-phosphofructokinase (<i>PFKM</i>) gene and of a truncating variant in the pseudouridine synthase 1 (<i>PUS1</i>) gene (both on Chromosome 12), resulting in a homozygous state of these mutations in his daughter. The <i>PFKM</i> gene functions in glycolysis and is linked to Tarui syndrome. The <i>PUS1</i> gene functions in mitochondrial tRNA processing and is linked to myopathy, lactic acidosis, and sideroblastic anemia (MLASA). Analysis of human dermal fibroblasts, which do not express <i>PFKM</i>, revealed a loss of <i>PUS1</i> mRNA and PUS1 protein only in the patient cells compared to healthy controls. The patient cells also revealed a reduction of the mitochondrial-encoded protein MTCO1, whereas levels of the nuclear-encoded SDHA remained unchanged, suggesting a specific impairment of mitochondrial translation. Further destabilization of these cells is suggested by the altered levels of BAX, BCL-2, and TP53 proteins, alterations that become augmented upon exposure of the cells to DNA damage. The results illustrate the efficacy of UPiD events to reveal rare pathogenic variants in human disease and demonstrate how these events can lead to cellular destabilization.
ChemInform Abstract: DIE PHOTOCHEMISCHE ZERS. VON TRIPHENYLTRIAZAFULVENEN (1973)

Abstract Aus den Triazolyl‐diphenylcarbinolen (Ia) und (Ib) bzw. (V) erhält man mit Thionylchlorid die Benzhydrylchloride (IIa) und (IIb) bzw. (VI), die zu den Triazafulvenen (IIIa), (IIIb) bzw. (VII) dehydrochloriert werden.
Optimizing spectral quality with quantum dots to enhance crop yield in controlled environments (2020)

Abstract Bioregenerative life-support systems (BLSS) involving plants will be required to realize self-sustaining human settlements beyond Earth. To improve plant photosynthetic efficiency in BLSS, the quality of the solar spectrum can be modified by lightweight, luminescent films. CuInS 2 /ZnS quantum dot (QD) films with peak emissions at 600 and 660 nm were used to redshift ultraviolet and blue photons to increase biomass accumulation in red romaine lettuce. Plant growth parameters, except spectral quality, were held constant among three equivalent production environments. Lettuce grown under the 600 and 660 nm-emitting QD films respectively increased edible dry mass (13% and 9%), edible fresh mass (11% each), and total leaf area (8% and 13%) compared to under a control film that contained no QDs. Spectral modifications by the luminescent QD films improved photosynthetic efficiency in lettuce and could enhance crop productivity in greenhouses on Earth or in space, where further improvements are expected from greater availability of ultraviolet photons for conversion.
ChemInform Abstract: A MILD AND EFFICIENT DEGRADATION OF RING A OF STEROIDS (1982)

Abstract Eschenmoser‐Tanabe‐ Fragmentierung des Hydroxyepoxyketons (I) liefert das erwartete Hydroxyketoalkin (IIa) und als Nebenprodukte das Acetat (IIb) und das Sulfinat (IIc); bei Verlängerung der Reaktionsdauer auf 24 h entstehen die Alkine (IIa), (IIb) und (IIc) im Verhältnis 1:222.
Dissipative effects on finite-Larmor-radius modified magnetohydrodynamic ballooning modes (1982)

Finite-ion-Larmor-radius (FLR) effects provide a band of additional stability for values of ..beta..(exactly equal to plasma pressure/magnetic pressure) exceeding the limit predicted for ideal magnetohydrodynamic (MHD) ballooning modes. We examine the effect of particle collisions on the stable modes of the FLR modified ideal theory that exist in this range of ..beta.. values.
User association with jointly maximising downlink sum rate and minimising uplink sum power for heterogeneous cellular networks (2015)

In heterogeneous cellular networks (HCNs), the user association is a challenging topic since some different base stations coexist. Moreover, because of the asymmetric uplink and downlink in HCNs, a joint uplink and the downlink association algorithm should be designed to improve the system performance. For the practical implementation, the authors need to ensure that the algorithm is highly effective. Thus, they try to design an association strategy that jointly maximises downlink sum rate and minimises uplink sum power, and formulate it as a sum‐utility maximisation problem. To solve this problem, they design a centralised association algorithm via a gradient descent method, and develop a distributed association algorithm via dual decomposition. Simulation results show that, compared with the signal strength‐based association, range expansion association and the method proposed by Ye, their scheme has some significant advantages in the mass.
THE MICROVASCULAR PATTERN OF THE ROTATOR CUFF (1970)

1. The avascular zone in the tendon of the supraspinatus near its insertion was not seen in the other tendons comprising the rotator cuff, except for the superior portion of the insertion of the infraspinatus which, on occasions, showed a small avascular area. The biceps tendon, however, also showed an avascular zone as it coursed over the head of the humerus. It is suggested that the anatomical disposition of these tendons makes them subject to constant pressure from the head of the humerus, which tends to wring out the blood supply to these tendons when the arm is held in the resting position of adduction and neutral rotation. 2. Although this study did not produce any evidence that the relative avascularity of the tendons over a prolonged period could be indicted as the sole cause of the degenerative changes that so commonly occur, it was noted that the degenerative changes occurred first and that they were always most extensive in the areas of avascularity. It was also observed that the zones of relative avascularity preceded, and were not the result of, the degenerative changes. 3. With the onset of tendon degeneration, secondary vascular phenomena were observed. Firstly, there was a reaction that appeared to be a foreign body inflammatory response with the development of vascular tufts of granulation tissue. It was thought that these vascular changes were secondary to the breakdown in the tendons and were not the cause of the breakdown as previously suggested by Anderson and Moore. it was noted, moreover, that with the progression of degenerative changes in the supraspinatus tendon, the tendon became much attenuated and, as it did so, the zone of relative avascularity appeared to extend. This secondary shut-down of the vascular bed might well be caused by an increased tension in the tendon. In those tendons in which spontaneous rupture had occurred, it was noted that the major part of the tendon proximal to the rupture was avascular and showed evidence of much degenerative change. This study therefore suggests that in the operative repair of such lesions it is necessary to excise the degenerate avascular tendon in order to effect a sound repair. It is also suggested that detachment of the supraspinatus muscle from the supraspinous fossa in order to advance the whole muscle belly is the only technique possible to enable the surgeon to replace healthy tendon directly into bone, as suggested by Debeyre and his colleagues.
Improved Release and Metabolism of Flavonoids by Steered Fermentation Processes: A Review (2014)

This paper provides an overview on steered fermentation processes to release phenolic compounds from plant-based matrices, as well as on their potential application to convert phenolic compounds into unique metabolites. The ability of fermentation to improve the yield and to change the profile of phenolic compounds is mainly due to the release of bound phenolic compounds, as a consequence of the degradation of the cell wall structure by microbial enzymes produced during fermentation. Moreover, the microbial metabolism of phenolic compounds results in a large array of new metabolites through different bioconversion pathways such as glycosylation, deglycosylation, ring cleavage, methylation, glucuronidation and sulfate conjugation, depending on the microbial strains and substrates used. A whole range of metabolites is produced, however metabolic pathways related to the formation and bioactivities, and often quantification of the metabolites are highly underinvestigated. This strategy could have potential to produce extracts with a high-added value from plant-based matrices.
The planar perfect lens: physical requirements and possible alternative realizations (2003)

Several alternative possibilities of how to create an electromagnetic device being able to reconstruct near-field distribution of a source with sub-wavelength resolution (so-called perfect lens) are considered. It is shown that there is a variety of such means not involving double-negative (left-handed, or Veselago) materials or periodical backward-wave structures. It is demonstrated that devices working in a similar manner can be constructed using planar grids or material sheets imposing necessary boundary conditions at two parallel planes in air.
Surfactants and automated analyses. (1986)

Journal Article Surfactants and automated analyses. Get access P Masson, P Masson Search for other works by this author on: Oxford Academic Google Scholar B Aksell, B Aksell Search for other works by this author on: Oxford Academic Google Scholar T Trulsson T Trulsson Search for other works by this author on: Oxford Academic Google Scholar Clinical Chemistry, Volume 32, Issue 3, 1 March 1986, Pages 559–560, https://doi.org/10.1093/clinchem/32.3.559b Published: 01 March 1986
DEPTH ESTIMATION OF METALLIC OBJECTS USING MULTIWAVELETS SCALE-SPACE REPRESENTATION (2008)

This is the published version: Bhatti, A. and Nahavandi, S. 2008, Depth estimation of metallic objects using multiwavelets scale-space representation, Current development in theory and applications of wavelets, vol.
Reduced Hypothalamic POMC and Anterior Pituitary CRF1 Receptor mRNA Levels After Acute, but Not Chronic, Daily “Binge”Intragastric Alcohol Administration (2000)

These results suggest that (1) rats exposed to chronic binge alcohol develop tolerance in HPA activity, as shown by no elevation of ACTH and an attenuated corticosterone response to chronic alcohol after initial dramatic elevations by acute alcohol administration; (2) a concurrent acute decrease in CRF1 receptor mRNA levels in the anterior pituitary is associated with increased HPA activity, and (3) alterations of POMC gene expression in the hypothalamic region may have implications for a molecular understanding of the neuroendocrine response to alcohol.
3D Is Back! (2014)

Editor in chief Miguel Encarnação discusses the special issue on Interacting above and beyond the Display. He also introduces the magazine's newest editorial board member, Manuel M. Oliveira of the Federal University of Rio Grande do Sul.
Nonalcoholic Steatohepatitis in Donors for Living Donor Liver Transplantation (2007)

Donor safety is a top priority in living donor liver transplantation. To exclude patients with NASH from potential donor lists, careful evaluation, including selective preoperative liver biopsy, should be carried out.
Randomized Phase II Trial of Erlotinib With and Without Entinostat in Patients With Advanced Non–Small-Cell Lung Cancer Who Progressed on Prior Chemotherapy (2012)

Erlotinib combined with entinostat did not improve the outcomes of patients in the overall study population when compared with erlotinib monotherapy. High E-cadherin expression levels at time of diagnosis indicate an increased sensitivity to HDACi/EGFR-TKI inhibition providing the basis for a biomarker-driven validation study.
Augmenting Granzyme B–Expressing NK Cells by Invariant NKT Ligand–Loaded APCs in Patients with Postoperative Early Stage Non–Small Cell Lung Cancer: Results of a Randomized Phase II Study (2023)

NK cells are major effector cells involved in the elimination of early tumors and prevent metastasis. They often have an impaired function in patients with cancer. Preclinical studies have demonstrated NK cell activation as the adjunctive effect of invariant NKT (iNKT) cells. Activation of iNKT cells after administration of the glycolipid ligand α-galactosylceramide, loaded with CD1d-expressing human PBMC-derived APCs (APC/Gal), is an attractive cancer therapy to optimize the use of NK cells. However, the subsets of NK cells that are activated following iNKT cell activation as well as the period of NK cell activation remain unclear. In this study, we report that the granzyme B-expressing NK cell response in postoperative lung cancer patients was enhanced 49 d after administration of APC/Gal in a phase II study. We found maximum IFN-γ production on day 49 in 13 out of 27 APC/Gal-treated patients. On day 49, 14 out of 27 patients (51.9%) had higher IFN-γ production by iNKT cells (>6-fold higher than the baseline level). This increment significantly correlated with granzyme B-expressing NK cells. Although IFN-γ production was lower in patients in the nontreated group, we detected maximum IFN-γ production 12 mo after the resection of lung cancer (9 out of 29 patients [31%]). These findings suggest that elimination of cancer cells leads to increased NK cell function, which can be further enhanced by APC/Gal therapy.
Monoclonal antibody (H107) inhibiting IgE binding to Fc epsilon R(+) human lymphocytes. (1986)

Abstract A hybridoma-producing monoclonal antibody blocking the binding of human IgE to lymphocytes Fc receptor (Fc epsilon R) was established by the fusion of murine myeloma cells. P3X63.653.Ag8, with BALB/c spleen cells immunized with Fc epsilon R(+) human B lymphoblastoid cell line cells, RPMI1788. A clone of the hybridoma (H107) produced a monoclonal IgG2b antibody that inhibited the rosette formation of Fc epsilon R(+) human B lymphoblastoid cell line cells (RPMI1788, RPMI8866, CESS, Dakiki, and IM9) with fixed ox red blood cells (ORBC) conjugated with human IgE (IgE-ORBC). In contrast, the rosette formation with IgG-conjugated ORBC (IgG-ORBC) on Fc gamma R(+), Fc epsilon R(-) Daudi cells were not affected by the H107 antibodies. A close association of Fc epsilon R and the antigenic determinant recognized by H107 antibody was suggested by the following results. First, the bindings of 125I-labeled IgE (125I-IgE) or 125I-labeled H107 IgG2b antibody (125I-H107) to RPMI8866 cells were inhibited by cold human IgE and H107 IgG2b but not by other classes of human Ig (IgA and IgG), MPC11 IgG2b, or unrelated monoclonal antibodies. Second, H107 antibody reacted with Fc epsilon R(+) B cell lines but not with Fc epsilon R(-) B cell lines as determined by an indirect immunofluorescence. Third, Fc epsilon R(+) cells were depleted by the incubation in the dish coated with H107 antibody or IgE but not in the dish coated with unrelated antibodies. Finally, there was a correlation between the increase of Fc epsilon R(+) cells and that of H107(+) cells in the peripheral blood lymphocytes of the patients with atopic dermatitis. The surface antigens on Fc epsilon R(+) RPMI8866 cells recognized by H107 antibodies had the molecular size of 45,000 as determined by immunoprecipitation and sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis.
Supplementary Table and Figures from Exportin-5 Functions as an Oncogene and a Potential Therapeutic Target in Colorectal Cancer (2023)

&lt;p&gt;Supplementary Table 1: Clinicopathological features of patients according to XPO5 expression (original validation cohort-2) Supplementary Table 2: Multivariate analysis for the predictors of disease-free survival in patients with colorectal cancer (original validation cohort-2) Supplementary Fig. 1: XPO5 expression analysis in discovery cohort. Supplementary Fig. 2: Clinicopathological significance of XPO5 expression in CRC patients Supplementary Fig. 3: The relationship between microsatellite status and XPO5 expression Supplementary Fig. 4: Intracellular localization of XPO5 Supplementary Fig. 5: pri-miRNA expression in siXPO5 CRC cells&lt;/p&gt;
A Sequential Estimation Technique for Recovering Atmospheric Data from Orbiting Satellites (2011)

This chapter contains sections titled: Introduction Optimal Estimation Sequential Estimation Smoothing Properties Examples
Supplementary Text from Reduced PDEF Expression Increases Invasion and Expression of Mesenchymal Genes in Prostate Cancer Cells (2023)

Supplementary Text from Reduced PDEF Expression Increases Invasion and Expression of Mesenchymal Genes in Prostate Cancer Cells
Sanglifehrin A, a Novel Cyclophilin-Binding Compound Showing Immunosuppressive Activity with a New Mechanism of Action (2001)

We report here on the characterization of the novel immunosuppressant Sanglifehrin A (SFA). SFA is a representative of a class of macrolides produced by actinomycetes that bind to cyclophilin A (CypA), the binding protein of the fungal cyclic peptide cyclosporin A (CsA). SFA interacts with high affinity with the CsA binding side of CypA and inhibits its peptidyl-prolyl isomerase activity. The mode of action of SFA is different from known immunosuppressive drugs. It has no effect on the phosphatase activity of calcineurin, the target of the immunosuppressants CsA and FK506 when complexed to their binding proteins CypA and FK binding protein, respectively. Moreover, its effects are independent of binding of cyclophilin. SFA inhibits alloantigen-stimulated T cell proliferation but acts at a later stage than CsA and FK506. In contrast to these drugs, SFA does not affect IL-2 transcription or secretion. However, it blocks IL-2-dependent proliferation and cytokine production of T cells, in this respect resembling rapamycin. SFA inhibits the proliferation of mitogen-activated B cells, but, unlike rapamycin, it has no effect on CD154/IL-4-induced Ab synthesis. The activity of SFA is also different from that of other known late-acting immunosuppressants, e.g., mycophenolate mofetil or brequinar, as it does not affect de novo purine and pyrimidine biosynthesis. In summary, we have identified a novel immunosuppressant, which represents, in addition to CsA, FK506 and rapamycin, a fourth class of immunophilin-binding metabolites with a new, yet undefined mechanism of action.