gebhart/patrepeval huggingface dataset:
Brief communication Antiviral effects of synthetic membrane-active peptides on Herpes Simplex Virus, Type 1 (1999)

Magainins are cationic peptides with antimicrobial activity which were originally isolated from the skin of the African clawed frog (Xenopus lae6is). Several synthetic derivatives of this class of peptides were evaluated for antiviral activity against herpes simplex virus, type 1 (HSV). Some of the peptides (MSI-102, -248, -420, -499:500 combination, -591, -594, and -1251) showed significant reduction of HSV plaque-forming units. The antiviral effect was enhanced when HSV was pretreated with the peptides prior to inoculation onto Vero monolayers, suggesting a direct effect on the virion. Most of the peptides with anti-HSV activity were lysine-rich, and the addition of octanoyl groups to the peptides appeared to enhance the antiviral effect. © 1999 Published by Elsevier Science B.V. and International Society of Chemotherapy. All rights reserved.
Some Implications of Radiation-Induced Property Changes in Austenitic Stainless Steels on ITER First-Wall Design and Performance (1991)

AbstractAbstractNew data on radiation-induced hardening, low-temperature creep and potential susceptibility (sensitization) to aqueous corrosion have been obtained on various heats of austenitic stainless steel (including type 316) irradiated at 60–400°C to 7–13 dpa. The data were obtained from spectral-tailoring reactor experiments, whose radiation-damage parameters are similar to those in the proposed International Thermonuclear Experimental Reactor (ITER) first-wall (FW) and blanket design. Austenitic stainless steels were found to increase significantly in strength at 60–330°C, to have higher irradiation-creep rates at 60°C than at 200–400°C, and to show radiation-induced changes in electrochemical properties at 200–400°C. These data on several radiation-induced property changes suggest that type 316 steel may be an adequate material for the FW of ITER. However, there is definitely a need for new data on fracture-toughness and on fatigue behavior below 400°C, as well as more data on irradiation-creep and effects of irradiation on corrosion properties, to better define temperature and dose dependencies for more detailed design analyses. Cold-working should remain an optional as-fabricated condition for the FW of ITER. Many properties of SA and CW 316 become similar after irradiation at 60–400°C. The higher initial yield-strength of CW 316 will allow higher design stress and elastic strain limits.
Production of isomaltulose obtained by Erwinia sp. cells submitted to different treatments and immobilized in calcium alginate (2011)

In recent decades, there has been an increase in the studies of isomaltulose obtainment, due to its physicochemical properties and physiological health benefits. These properties, which include low cariogenicity, low glycemic index and greater stability, allow the use of this sweetener as a substitute for sucrose in foods; besides the fact that it can be converted to isomalt, a dietary non-cariogenic sugar alcohol used in pharmaceuticals as well as in the food industry. Isomaltulose (6-O-α-D-glucopyronosyl-1-6-D-fructofuranose) is a disaccharide reducer obtained by the enzymatic conversion of sucrose - the α-glucosyltransferase enzyme. Different treatments were performed for the preparation of whole cells; lysed cells; and crude enzyme extract of Erwinia sp. D12 strain immobilized in calcium alginate. The packed bed column of granules, containing Erwinia sp. cells sonicated and immobilized in calcium alginate (CSI), reached a maximum conversion of 53-59% sucrose into isomaltulose and it presented activity for 480 hours. The converted syrup was purified and the isomaltulose crystallization was performed through the lowering of temperature. The isomaltulose crystals presented purity of 96.5%.
Refractive index matching and clear emulsions (2005)

Refractive index (RI) matching is a unique way of making clear emulsions to meet market trends. However, RI matching has not been sufficiently investigated in terms of physical principles and methodologies. Snell's law (n2 sin r2= n1 sin r1) is applicable to cosmetic emulsions. When oil phase and water phase have equal RI (n2 = n1) values, light will not bend as it strikes obliquely at the emulsion interface. Instead, light is transmitted through the emulsion without refraction, which produces clarity. Theoretical RI values in solution can be calculated with summation of the product of the weight percentage and refractive index of each ingredient (RI(mix) = [W1 x n1 + W2 x n2 + W3 x n3 + + Wn x nn]Wtau). Oil-phase RI values are normally at 1.4 or higher. Glycols are used to adjust the water phase RI, since they typically have larger RI values than water. Noticeable deviations from calculated RI values are seen in experimentally prepared solutions. Three basic deviation types are observed: negative, positive, and slightly negative or positive, which can occur in glycol aqueous solutions at different concentrations. The deviations are attributed to changes in molecular interaction between molecules in solution, which can lead to changes in specific gravity. Negative RI deviation corresponds to a decrease in specific gravity, and positive RI deviation corresponds to an increase in specific gravity. RI values will deviate from calculated values since an increase or decrease in specific gravity leads to a change in optical density.
Creation of Interface States by Avalanche Effect (1967)

Charge and interface states are introduced into the oxide in an MOS capacitor by producing avalanche break-down at the semiconductor surface. Both the charge trapped in the oxide and the interface states can be annealed out at low temperatures.
ATAQS: A computational software tool for high throughput transition optimization and validation for selected reaction monitoring mass spectrometry (2011)

Targeted proteomics via SRM is a powerful new technique that enables the reproducible and accurate identification and quantification of sets of proteins of interest. ATAQS is the first open-source software that supports all steps of the targeted proteomics workflow. ATAQS also provides software API (Application Program Interface) documentation that enables the addition of new algorithms to each of the workflow steps. The software, installation guide and sample dataset can be found in http://tools.proteomecenter.org/ATAQS/ATAQS.html.
Numerical simulation of explosion processes in fronzen soil (2007)

At present, there are numerous experimental and theoretical papers concerned with the behavior of soft soils under explosive loading; e.g., see [1–5]. The case of frozen soils is quite different. There are known only a few papers presenting the results of experimental [6–8] and numerical [9, 10] studies. The numerical results were obtained by solving one-dimensional problems on the explosion of a spherical charge. In the present paper, we give the results of numerical studies of wave processes caused by the explosion of a spherical charge in a homogeneous or layered frozen soil with allowance for the free surface and the finite depth of the freezing boundary. Frozen and soft soils are modeled by Grigoryan’s medium with irreversible bulk and shear strains. We analyze how the free boundary and the interface affect the wave parameters. The results of numerical calculations are compared with known experimental data.
Regulatory mechanisms in the expression of cell cycle dependent genes. (1987)

There are several prominent features of cell cycle dependent gene regulation which are apparent from the data reviewed here. First, almost all of the genes studied are regulated by a combination of transcriptional and post transcriptional mechanisms. Thus, the regulation of mRNA levels through the cell cycle is a complex process, with control at many different levels. This is not surprising, if we keep in mind that the modulation of these mRNAs at the proper times may be critical to cell division. Secondly, there does not appear to be a common theme in the regulation of the genes discussed here. It appears as if each gene will be regulated by its own specific mechanism. Table 3 shows the serum responsive sequences which have been identified so far, and they are all different; there does not appear to be a consensus sequence yet for a serum response element. The identification of more such sequences should be forthcoming, and should give us a better idea of the general and specific nature of growth factor regulation of gene expression. We know less about the regulation of genes at the posttranscriptional level than about their transcription. We still have very little information about the specific sequences in mRNA which render it susceptible to degradation. Elucidation of such sequences, such as the AU rich region in GM-CSF mRNA should help us to understand serum and growth-factor gene regulation, since this means of control is as widespread, and probably as important as transcriptional control. We have only just begun to understand the mechanisms controlling the expression of CCD genes. The next few years should bring a great increase in our knowledge of these processes.
A Completely Detachable Aortic Clamping Instrument for Minimally Invasive Cardiac Surgery (2010)

A minimally invasive cardiac surgery is becoming more popular and is still undergoing a refinement of surgical techniques and dedicated instrumentarium as well. New specifically designed instruments are quintessence of safe surgery with improving operative outcomes and comfortable operator-oriented working conditions. In this article, we attempt to present our early clinical experience with a new aortic clamping instrument specifically developed for limited single-access minimally invasive valve surgery.
Cannabidiol and Sports Performance: a Narrative Review of Relevant Evidence and Recommendations for Future Research (2020)

Cannabidiol (CBD) is a non-intoxicating cannabinoid derived from Cannabis sativa. CBD initially drew scientific interest due to its anticonvulsant properties but increasing evidence of other therapeutic effects has attracted the attention of additional clinical and non-clinical populations, including athletes. Unlike the intoxicating cannabinoid, Δ<sup>9</sup>-tetrahydrocannabinol (Δ<sup>9</sup>-THC), CBD is no longer prohibited by the World Anti-Doping Agency and appears to be safe and well-tolerated in humans. It has also become readily available in many countries with the introduction of over-the-counter "nutraceutical" products. The aim of this narrative review was to explore various physiological and psychological effects of CBD that may be relevant to the sport and/or exercise context and to identify key areas for future research. As direct studies of CBD and sports performance are is currently lacking, evidence for this narrative review was sourced from preclinical studies and a limited number of clinical trials in non-athlete populations. Preclinical studies have observed robust anti-inflammatory, neuroprotective and analgesic effects of CBD in animal models. Preliminary preclinical evidence also suggests that CBD may protect against gastrointestinal damage associated with inflammation and promote healing of traumatic skeletal injuries. However, further research is required to confirm these observations. Early stage clinical studies suggest that CBD may be anxiolytic in "stress-inducing" situations and in individuals with anxiety disorders. While some case reports indicate that CBD improves sleep, robust evidence is currently lacking. Cognitive function and thermoregulation appear to be unaffected by CBD while effects on food intake, metabolic function, cardiovascular function, and infection require further study. CBD may exert a number of physiological, biochemical, and psychological effects with the potential to benefit athletes. However, well controlled, studies in athlete populations are required before definitive conclusions can be reached regarding the utility of CBD in supporting athletic performance.
Multichannel CSMA with signal power-based channel selection for multihop wireless networks (2002)

We describe a new carrier-sense multiple access (CSMA) protocol for multihop wireless networks, using multiple channels and a distributed channel selection scheme. The proposed protocol divides the available bandwidth into N channels where the transmitting station selects an appropriate channel for packet transmission. The selection criterion is based on the interference power measurements on the channels. We show via simulations that this multichannel CSMA protocol provides a higher throughput compared to its single channel counterpart by reducing the packet loss due to collisions.
Reaching Grid Parity Using BP Solar Crystalline Silicon Technology: A Systems Class Application (2010)

The primary target market for this program was the residential and commercial PV markets, drawing on BP Solar's premium product and service offerings, brand and marketing strength, and unique routes to market. These two markets were chosen because: (1) in 2005 they represented more than 50% of the overall US PV market; (2) they are the two markets that will likely meet grid parity first; and (3) they are the two market segments in which product development can lead to the added value necessary to generate market growth before reaching grid parity. Federal investment in this program resulted in substantial progress toward the DOE TPP target, providing significant advancements in the following areas: (1) Lower component costs particularly the modules and inverters. (2) Increased availability and lower cost of silicon feedstock. (3) Product specifically developed for residential and commercial applications. (4) Reducing the cost of installation through optimization of the products. (5) Increased value of electricity in mid-term to drive volume increases, via the green grid technology. (6) Large scale manufacture of PV products in the US, generating increased US employment in manufacturing and installation. To achieve these goals BP Solar assembled a team that included suppliers of critical materials, automated equipment developers/manufacturers, inverter and other BOS manufacturers, a utility company, and University research groups. The program addressed all aspects of the crystalline silicon PV business from raw materials (particularly silicon feedstock) through installation of the system on the customers site. By involving the material and equipment vendors, we ensured that supplies of silicon feedstock and other PV specific materials like encapsulation materials (EVA and cover glass) will be available in the quantities required to meet the DOE goals of 5 to 10 GW of installed US PV by 2015 and at the prices necessary for PV systems to reach grid parity in 2015. This final technical report highlights the accomplishments of the BP Solar technical team from 2006 to the end of the project in February 2010. All the main contributors and team members are recognized for this accomplishment and their endeavors are recorded in the twelve main tasks described here.
A Coupled Feature-Filter Clustering Scheme for Resolution Synthesis (2007)

For many digital image/video processing applications increasing the spatial resolution through modifications in the imaging system is infeasible. Hence post-processing algorithms designed to enhance resolution of the acquired image data prove beneficial. In this paper, we analyze recent work on classification based resolution enhancement and discuss its applicability to low-complexity display systems. In the light of our observations we point out certain short-comings of resolution synthesis and propose a modified training scheme to improve the performance under certain conditions.
Projection based advanced motion model for cubic mapping for 360-degree video (2017)

This paper proposes a novel advanced motion model to handle the irregular motion for the cubic map projection of 360-degree video. Since the irregular motion is mainly caused by the projection from the sphere to the cube map, we first try to project the pixels in both the current picture and reference picture from unfolding cube back to the sphere. Then through utilizing the characteristic that most of the motions in the sphere are uniform, we can derive the relationship between the motion vectors of various pixels in the unfold cube. The proposed advanced motion model is implemented in the High Efficiency Video Coding reference software. Experimental results demonstrate that quite obvious performance improvement can be achieved for the sequences with obvious motions.
Efficient hybrid space-ground precoding techniques for multi-beam satellite systems (2017)

Multi-beam mobile satellite systems aim at providing broadband and high speed mobile services over a large area to achieve a high system throughput, where hybrid space-ground beamforming is one of the most promising candidates for ground-based beamforming techniques. It not only reduces the feeder link bandwidth to save spectral resources, but also takes advantages of both the on-ground and on-board processing, exhibiting a good trade-off of the performance and the space/ground complexity. In this paper, we propose an efficient hybrid space-ground precoding technique for multi-beam mobile satellite systems. It consists of coarse on-board beamforming and reduced-rank on-ground beamforming based on the feed selection of the phased array antenna. The advantages of the proposed hybrid precoding are shown as compared to the fully on-ground beamforming as well as the existing solutions.
Molecular Architecture and Functional Analysis of NetB, a Pore-forming Toxin from Clostridium perfringens (2012)

NetB is a pore-forming toxin produced by Clostridium perfringens and has been reported to play a major role in the pathogenesis of avian necrotic enteritis, a disease that has emerged due to the removal of antibiotics in animal feedstuffs. Here we present the crystal structure of the pore form of NetB solved to 3.9 Å. The heptameric assembly shares structural homology to the staphylococcal α-hemolysin. However, the rim domain, a region that is thought to interact with the target cell membrane, shows sequence and structural divergence leading to the alteration of a phosphocholine binding pocket found in the staphylococcal toxins. Consistent with the structure we show that NetB does not bind phosphocholine efficiently but instead interacts directly with cholesterol leading to enhanced oligomerization and pore formation. Finally we have identified conserved and non-conserved amino acid positions within the rim loops that significantly affect binding and toxicity of NetB. These findings present new insights into the mode of action of these pore-forming toxins, enabling the design of more effective control measures against necrotic enteritis and providing potential new tools to the field of bionanotechnology.
Fusing diagnostic information without a priori performance knowledge (2000)

Diagnostic information fusion is the method by which one would determine a system's state for those instances where several different diagnostic tools, and possibly other sources, are used for state estimation. Because system state predictions from different diagnostic tools will disagree to some extent, if not completely contradict one another, a robust fusion tool is necessary to produce a reliable assessment of system state. The paper addresses the need for a reliable solution to the problem of diagnostic information fusion, particularly with the absence of a priori knowledge of diagnostic tool performance. Tool performance specifications are often hard to come by, in particular where data about events are sparse or where a comprehensive evaluation cannot be performed. In response, a fusion process, using a set of neural networks, was developed to distinguish recognizable patterns from the output of the individual diagnostic tools. This fusion concept was applied to data that were gathered from a high-speed milling machine and processed by several previously developed diagnostic tools.
The separation between the 5′-3′ ends in long RNA molecules is short and nearly constant (2014)

RNA molecules play different roles in coding, decoding and gene expression regulation. Such roles are often associated to the RNA secondary or tertiary structures. The folding dynamics lead to multiple secondary structures of long RNA molecules, since an RNA molecule might fold into multiple distinct native states. Despite an ensemble of different structures, it has been theoretically proposed that the separation between the 5' and 3' ends of long single-stranded RNA molecules (ssRNA) remains constant, independent of their base content and length. Here, we present the first experimental measurements of the end-to-end separation in long ssRNA molecules. To determine this separation, we use single molecule Fluorescence Resonance Energy Transfer of fluorescently end-labeled ssRNA molecules ranging from 500 to 5500 nucleotides in length, obtained from two viruses and a fungus. We found that the end-to-end separation is indeed short, within 5-9 nm. It is remarkable that the separation of the ends of all RNA molecules studied remains small and similar, despite the origin, length and differences in their secondary structure. This implies that the ssRNA molecules are 'effectively circularized' something that might be a general feature of RNAs, and could result in fine-tuning for translation and gene expression regulation.
α-Conotoxin ImI Incorporating Stable Cystathionine Bridges Maintains Full Potency and Identical Three-Dimensional Structure (2011)

The two disulfide bonds of α-conotoxin ImI, a peptide antagonist of the α7 nicotinic acetylcholine receptor (nAChR), were systematically replaced with isosteric redox-stable cystathionine thioethers. Regioselective thioether formation was accomplished on solid support through substitution of a γ-chlorohomoalanine by an intramolecular cysteine thiol to produce hybrid thioether/disulfide analogues (2 and 3) as well as a dual cystathionine analogue (4) that were found to be structurally homologous to α-conotoxin ImI by (1)H NMR. The antagonistic activity at the α7 nAChR of cystathionine analogue 3 (pIC(50) = 6.41 ± 0.09) was identical to that of α-conotoxin ImI (1, pIC(50) = 6.41 ± 0.09), whereas those of 2 (pIC(50) = 5.96 ± 0.09) and 4 (pIC(50) = 5.89 ± 0.09) showed a modest decrease. The effect of oxidation of the thioethers to sulfoxides was also investigated, with significant changes in the biological activities observed ranging from a >30-fold reduction (2S═O) to a 3-fold increase (3S═O(B)) in potencies.
The Radiation Chemistry of Ionic Liquids: A Review (2014)

Ionic liquids have received increasing attention as media for radiochemical separations. Recent literature includes examinations of the efficiencies and mechanisms of the solvent extraction of lanthanides, actinides and fission products into ionic liquid solutions. For radiochemical applications, including as replacement solvents for nuclear fuel reprocessing, a thorough understanding of the radiation chemistry of ionic liquids will be required. Such an understanding can be achieved based on a combination of steady-state radiolysis experiments coupled with post-irradiation product identification and pulse-radiolysis experiments to acquire kinetic information. These techniques allow for the elucidation of radiolytic mechanisms. This contribution reviews the current ionic liquid radiation chemistry literature as it affects separations, with these considerations in mind.