gebhart/patrepeval huggingface dataset:
The Fixing of Molecular Orientation (1948)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Fixing of Molecular OrientationJohn F. DreyerCite this: J. Phys. Chem. 1948, 52, 5, 808–810Publication Date (Print):May 1, 1948Publication History Published online1 May 2002Published inissue 1 May 1948https://doi.org/10.1021/j150461a005Request reuse permissionsArticle Views57Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (194 KB) Get e-Alerts
Dynamics and Counterion‐Dependence of the Structures of Weakly Bound Ag+—P4S3 Complexes. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
STAR-RIS-NOMA Networks: An Error Performance Perspective (2022)

This letter investigates the bit error rate (BER) performance of simultaneous transmitting and reflecting reconfigurable intelligent surfaces (STAR-RISs) in non-orthogonal multiple access (NOMA) networks. In the investigated network, a STAR-RIS serves multiple non-orthogonal users located on either side of the surface by utilizing the mode switching protocol. We derive the closed-form BER expressions in perfect and imperfect successive interference cancellation cases. Furthermore, asymptotic analyses are also conducted to provide further insights into the BER behavior in the high signal-to-noise ratio region. Finally, the accuracy of our theoretical analysis is validated through Monte Carlo simulations. The obtained results reveal that the BER performance of STAR-RIS-NOMA outperforms that of the classical NOMA system, and STAR-RIS might be a promising NOMA 2.0 solution.
Substrate adhesion affects contraction and mechanical properties of fibroblast populated collagen lattices (2007)

Fibroblasts can condense a hydrated collagen lattice to a tissue-like structure. The purpose of this study was to evaluate the effect of substrate adhesion on the contraction and mechanical properties of fibroblast populated collagen lattices. Bacteriological grade polystyrene (BGPS) plates and tissue culture polystyrene (TCPS) plates were used as substrates for incubation of fibroblast populated collagen lattices. Hydrophobicity of the polystyrene surfaces was measured by the static sessile contact angle method. Collagen lattice contraction was recorded for 2 weeks, after which the lattices were mechanically tested. The BGPS culture plate had a significantly larger contact angle and was more hydrophobic than the TCPS culture plate. Both hydrophobicity and peripheral detachment of the collagen gel significantly decreased the time lag before initiation of gel contraction and increased the strength of the fibroblast populated collagen lattices. Substrate adhesion affects the contractility and strength of cell seeded collagen gels. This information may be useful in developing tissue engineered tendons and ligaments.
Doped non‐conjugated polymers with enhanced electrical conductivity, 3. Iodine doping of a liquid crystalline polymer (1997)

Abstract Doping with iodine of a liquid crystalline polymer in its different states was investigated for the first time. It was established that the polymer cannot be doped in solution, but it was doped to different, but rather high levels in the solid state and in frozen liquid crystalline and isotropic states. The products obtained exhibit intensive absorption in the visible region, higher electrical conductivity and paramagnetism. The successful doping of this non‐conjugated polymer in the solid state was explained by a collective interaction of several conjugated parts of the macromolecules (acting as extended conjugation) with iodine.
Microseismicity in the middle Okinawa trough (1989)

We conducted a microearthquake survey with ocean bottom seismometers (OBS) in the middle Okinawa trough in 1984. During about one month of operation, very active microseismicity was observed. The microearthquake activity was characterized by the ceaseless occurrence of numerous small earthquakes in the vicinity of OBS stations. This activity was recorded by almost every OBS station but not by land‐based instruments. Swarm activities also occurred at many places. Average activity levels of earthquakes whose durations are longer than 30 s, recorded at individual OBSs, are from 4 to 20 events per day, which seem higher than those of ordinary mid‐oceanic ridge‐fracture zone systems and other back arc basins. Apparently, the number of smaller size earthquakes is fewer than expected. This might indicate the rather high attenuation of seismic waves or low‐Q of the crust around OBS stations, which makes it difficult to detect small size events at a distant range. Attenuation of seismic waves was large beyond the epicentral distance of about 120 km. This seems to indicate low‐Q in the lower crust. Also, a particularly low‐Q area was found at the northern most part of the research area where high heat flow measurements were obtained. This suggests that igneous activity reaches to the surface in that vicinity from the bottom of the crust where magmatic activity has been implied in other studies. At least two types of swarm activities are indicated for this area. Some have no dominant events, show high “b” value properties, and seem to be volcanic. Others have dominant events and appear to be tectonic in nature. Among the swarm activity, two kinds of signals closely resembling volcanic tremors were observed. From these features, we conclude that the crust of this area is highly fractured and subject to intense tectonic activities, as well as some kind of igneous processes.
Neonatal protection and preterm birth reduction following maternal group Bstreptococcusvaccination in a mouse model (2016)

Our finding suggest that vaccinated mothers could protect their progeny from GBS infection and preterm birth through passive immunization. The proposed mouse model may represent a noninvasive and effective tool to investigate pathogenetic mechanisms of GBS ascending infection and for vaccine protection studies.
Discovery of [18F]ACI‐12589, a Novel and Promising PET‐Tracer for Alpha‐Synuclein (2022)

Abstract Background Parkinson’s disease (PD) and other synucleinopathies such as Multiple System Atrophy (MSA) involve a progressive accumulation of a‐synuclein (a‐syn) inclusions that correlates with disease stage and clinical manifestations. The development of a PET agent capable of imaging a‐syn inclusions would significantly aid in differential diagnosis, staging, and monitoring possible benefits of candidate therapeutic agents targeting a‐syn. Due to the generally lower pathologic burden of a‐syn inclusions relative to other brain proteinopathies, a reliable a‐syn PET tracer must display high binding affinity and selectivity for its intended target. Method Using our proprietary Morphomer ® library of low‐molecular weight and conformation‐specific ligands, compounds with good affinity and target occupancy were identified. We then iteratively performed medicinal chemistry optimization cycles to further improve on‐target binding properties and selectivity based on radiobinding and classical and high‐resolution autoradiography results. Optimized compounds were then assessed further for off‐target activities and evaluated for their brain pharmacokinetic properties in non‐human primates (NHPs). The clinical candidate [18F]ACI‐12589 was subsequently advanced through preclinical assessment prior to evaluation in a clinically diverse set of synucleinopathy subjects and controls. Result Promising chemical scaffolds with high‐affinity binding to pathological a‐syn in tissue homogenates and sections have been optimized. Particularly, ACI‐12589 demonstrated improved target occupancy on different synucleinopathy samples, including PD and MSA, with a binding pattern aligning closely with the distribution of pathological a‐syn. Moreover, ACI‐12589 demonstrated selectivity for a‐syn versus other potential amyloid pathologies including amyloid‐beta, Tau, and TDP‐43. In NHPs [ 18 F]ACI‐12589 revealed good brain uptake, homogenous distribution and fast washout. Initial results from the ongoing clinical trials confirm favorable pharmacokinetic parameters in patients, including rapid signal equilibration, potentially allowing short scan times. Moreover, initial clinical data in MSA patients indicate that [ 18 F]ACI‐12589 uptake occurs in brain areas affected by the disease process based on clinical manifestations. Conclusion [ 18 F]ACI‐12589 displays preclinical and clinical characteristics deemed necessary to become a reliable PET radiotracer for the imaging of a‐syn inclusions. Interestingly, ex‐vivo data from different synucleinopathy tissues is in accordance with the promising clinical data in MSA that will be presented by R. Smith et al. at this conference.
The design of thin-film polysilicon resistors for analog IC applications (1989)

The authors describe the design of thin LPCVD polysilicon resistors based on their desired electrical performance (sheet resistance, temperature coefficient, voltage nonlinearity, and matching and uniformity). Based on measured data and an understanding of polysilicon carrier transport phenomena, it is shown how resistor processes can be designed for a wide variety of analog IC (integrated circuit) applications, requiring only ion implantation and standard polysilicon deposition and patterning processes. For a +or-500 p.p.m./ degrees C temperature coefficient of resistance range, the available sheet resistance lies between 2400 and 40 Omega /sq. for a polysilicon thickness ranging from 50-600 nm. Matching and nonlinearity (in a 10-V range) to better than 0.06% has been achieved from a process designed as described. Thus it is demonstrated that performance comparable to thin sputtered resistor films can be achieved without the requirement of a long development time and specialized knowledge.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Nonsteroidal hypocholesteremic agents. II. Synthesis and serum sterol lowering properties of 4-(2-dialkylaminoalkoxy)-4'-substituted biphenyls and related compounds (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNonsteroidal hypocholesteremic agents. II. Synthesis and serum sterol lowering properties of 4-(2-dialkylaminoalkoxy)-4'-substituted biphenyls and related compoundsFrederick L. Bach, John C. Barclay, Frances Kende, and Elliott CohenCite this: J. Med. Chem. 1968, 11, 5, 987–993Publication Date (Print):September 1, 1968Publication History Published online1 May 2002Published inissue 1 September 1968https://pubs.acs.org/doi/10.1021/jm00311a017https://doi.org/10.1021/jm00311a017research-articleACS PublicationsRequest reuse permissionsArticle Views61Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
DexPilot: Vision-Based Teleoperation of Dexterous Robotic Hand-Arm System (2020)

Teleoperation offers the possibility of imparting robotic systems with sophisticated reasoning skills, intuition, and creativity to perform tasks. However, teleoperation solutions for high degree-of-actuation (DoA), multi-fingered robots are generally cost-prohibitive, while low-cost offerings usually offer reduced degrees of control. Herein, a low-cost, depth-based teleoperation system, DexPilot, was developed that allows for complete control over the full 23 DoA robotic system by merely observing the bare human hand. DexPilot enabled operators to solve a variety of complex manipulation tasks that go beyond simple pick-and-place operations and performance was measured through speed and reliability metrics. DexPilot cost-effectively enables the production of high dimensional, multi-modality, state-action data that can be leveraged in the future to learn sensorimotor policies for challenging manipulation tasks. The videos of the experiments can be found at https://sites.google.com/view/dex-pilot.
A Potential Wasteform for Cs Immobilization: Synthesis, Structure Determination, and Aqueous Durability of Cs2TiNb6O18 (2016)

Cs<sub>2</sub>TiNb<sub>6</sub>O<sub>18</sub> is a potential ceramic wasteform for the long-term immobilization of radioactive cesium. Cs<sub>2</sub>TiNb<sub>6</sub>O<sub>18</sub> was synthesized using the aqueous precursor method and a solid-state reaction, and its crystal structure was determined from the Rietveld refinement of synchrotron X-ray and neutron powder diffraction data. The structure is a pyrochlore analogue, space group P3̅m1 with Cs in 9-fold coordination. The calculated bond valence sum from analysis of neutron diffraction data of 0.84 and high coordination number suggest that Cs has a strong bonding environment. The chemical aqueous durability was investigated using the MCC-1 and PCT-B standard test methods. The measured Cs leach rates of 3.8 × 10<sup>-3</sup> and 2.1 × 10<sup>-3</sup> g m<sup>-2</sup> day<sup>-1</sup> obtained via the MCC-1 and PCT-B methods, respectively, demonstrate good promise of a safe long-term immobilization material comparable to, if not better than, hollandite-the material in the multiphase titanate ceramics (Synroc) targeted for cesium sequestration.
Channel Assignment, Stream Control, Scheduling and Routing in Multi-Radio MIMO Wireless Mesh Networks (2009)

Multi-hop wireless mesh networks are designed as a cost-effective solution for last-mile broadband Internet access. Equipping mesh nodes with multiple radios further improves network capacity by using multiple radios to transmit simultaneously on orthogonal channels. In addition, multiple input multiple output (MIMO) antennas have emerged as a physical layer breakthrough for increasing throughput and suppressing interference from neighboring links. These wireless technologies are viewed as the key components in improving the performance of next-generation wireless networks. However, to obtain the full benefits of these technologies, the networking protocols should exploit their capabilities in a systematic way due to their interdependence. In this paper, we provide the first formal study on cross-layer optimization in multi-radio, multi-channel wireless mesh networks with MIMO links. We formulate a framework where data routing at the network layer, link scheduling and channel assignment at the MAC layer, and MIMO stream control at the physical layer can be jointly optimized for maximizing network throughput subject to fairness constraint among mesh nodes. We then present an algorithm in which routing is established on a longer-time scale for system stability, while scheduling, channel assignment and stream control are jointly determined for opportunistic bandwidth access and sharing in time, frequency and space dimensions based on instantaneous channel conditions and traffic dynamics.
The Importance of MTHFR C677T/A1298C Combined Polymorphism in Deep Vein Thrombosis: A Case Report (2022)

A 37-year-old woman presented in the emergency room with abdominal pain and nausea for about three weeks. She had no known risk factors for venous thromboembolism beyond taking oral contraceptives as a regular medication. Computed tomography (CT) scan revealed portal, superior mesenteric and splenic vein thrombosis. Thrombophilia tests were negative, except for the presence of heterozygosity for mutation of the methylenetetrahydrofolate reductase (<i>MTHFR</i>) gene. Homocysteine levels and folic acid were normal. Anticoagulation was started. Follow-up CT after eight months showed cavernous transformation of the portal vein.
Hemoglobin−Superoxide DismutaseChemical Linkages That Create a Dual-Function Protein (2005)

Chemical reagents were designed to cross-link and connect hemoglobin and superoxide dismutase, combining the oxygen transport and superoxide-removal capabilities of the red cell in a dual-function protein. Reaction of 1 with thiol-protected hemoglobin followed by reduction produces cross-linked hemoglobin with a free thiol on the cross-link. Reaction of SOD with 5 produces a cross-linked protein with a maleimide on the cross-link. Addition of the hemoglobin-thiol to the SOD-maleimide produces a protein with the desired dual properties. Hemoglobin's oxygenation cooperativity is lowered as a result of being in the conjugate, while SOD's activity is equal to that of the native protein.
Extensive eccentric contractions in intact cardiac trabeculae: revealing compelling differences in contractile behaviour compared to skeletal muscles (2019)

Force enhancement (FE) is a phenomenon that is present in skeletal muscle. It is characterized by progressive forces upon active stretching-distinguished by a linear rise in force-and enhanced isometric force following stretching (residual FE (RFE)). In skeletal muscle, non-cross-bridge (XB) structures may account for this behaviour. So far, it is unknown whether differences between non-XB structures within the heart and skeletal muscle result in deviating contractile behaviour during and after eccentric contractions. Thus, we investigated the force response of intact cardiac trabeculae during and after isokinetic eccentric muscle contractions (10% of maximum shortening velocity) with extensive magnitudes of stretch (25% of optimum muscle length). The different contributions of XB and non-XB structures to the total muscle force were revealed by using an actomyosin inhibitor. For cardiac trabeculae, we found that the force-length dynamics during long stretch were similar to the total isometric force-length relation. This indicates that no (R)FE is present in cardiac muscle while stretching the muscle from 0.75 to 1.0 optimum muscle length. This finding is in contrast with the results obtained for skeletal muscle, in which (R)FE is present. Our data support the hypothesis that titin stiffness does not increase with activation in cardiac muscle.
Oxygen-17 Nuclear Magnetic Resonance Studies of the Equilibria between the Enol Forms of β-Diketones (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxygen-17 Nuclear Magnetic Resonance Studies of the Equilibria between the Enol Forms of β-DiketonesMalka. Gorodetsky, Zeev. Luz, and Yehuda. MazurCite this: J. Am. Chem. Soc. 1967, 89, 5, 1183–1189Publication Date (Print):March 1, 1967Publication History Published online1 May 2002Published inissue 1 March 1967https://pubs.acs.org/doi/10.1021/ja00981a026https://doi.org/10.1021/ja00981a026research-articleACS PublicationsRequest reuse permissionsArticle Views243Altmetric-Citations102LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Expression of the Neutrophil Chemoattractant Interleukin-8 in the Lesions of Bovine Pneumonic Pasteurellosis (1998)

We investigated the expression of interleukin-8 (IL-8) in pneumonic pasteurellosis of cattle because neutrophils are important mediators of tissue injury in this disease and because IL-8 is a major neutrophil chemoattractant in other species. We also compared IL-8 expression in bacterial and viral pneumonia, since the latter lacks the severe neutrophil exudation typical of pneumonic pasteurellosis. IL-8 expression was assessed by northern analysis, in situ hybridization, enzyme-linked immunosorbent assay, and in vivo bioassay. IL-8 mRNA expression was elevated dramatically in lesions of pneumonic pasteurellosis compared to unaffected lung from the same calves. In situ hybridization revealed intense expression of IL-8 mRNA in alveolar macrophages and neutrophils and milder expression in bronchiolar and alveolar epithelium, interstitial cells, and pleural mesothelium. Bronchoalveolar lavage fluid from lesional lung contained 16.06+/-4.00 ng/ml IL-8, whereas those from nonlesional and normal lung contained 0.34+/-0.11 and 0.01+/-0.002 ng/ml, respectively. We detected IL-8 expression at only minimal levels in bovine respiratory syncytial viral pneumonia. Lung extracts from lesions of pneumonic pasteurellosis induced vigorous neutrophil infiltration following injection into bovine skin, and 89% depletion of IL-8 from the extract reduced this neutrophil influx by 60%. These results demonstrate consistent upregulation of IL-8 expression in lesions of pneumonic pasteurellosis, implying a role for IL-8 in the ongoing recruitment of neutrophils to established lesions of pneumonic pasteurellosis. Because neutrophil-mediated tissue injury is critical to the pathogenesis of pneumonic pasteurellosis, these data suggest that neutralization of IL-8 activity could ameliorate the severe clinical signs and lesions of this disease.
Supplementary Methods and Tables from Peptide–Drug Conjugate GnRH–Sunitinib Targets Angiogenesis Selectively at the Site of Action to Inhibit Tumor Growth (2023)

&lt;p&gt;Supplementary Methods 1 - Overall Synthesis of sunitinib analogues (SAN1-SAN5) Supplementary Methods 2 - Computational analysis Supplementary Methods 3 - Synthesis of the conjugate SAN1GSC Supplementary Methods 4 - Biochemical Tyrosine Kinase Assay Supplementary Methods 5 - Cellular autophosphorylation assay Supplementary Methods 6 - Overall phenotypic health evaluation and monitoring of body weight Supplementary Methods 7 - Cardiotoxicity studies Supplementary Methods 8 - Blood toxicity Table S1 - List of GST- fusion proteins Table S2 - List of Antibodies&lt;/p&gt;