gebhart/patrepeval huggingface dataset:
Secondary Cells with Lithium Anodes and Immobilized Fused-Salt Electrolytes (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSecondary Cells with Lithium Anodes and Immobilized Fused-Salt ElectrolytesHiroshi Shimotake, G. L. Rogers, and E. J. CairnsCite this: Ind. Eng. Chem. Process Des. Dev. 1969, 8, 1, 51–56Publication Date (Print):January 1, 1969Publication History Published online1 May 2002Published inissue 1 January 1969https://pubs.acs.org/doi/10.1021/i260029a009https://doi.org/10.1021/i260029a009research-articleACS PublicationsRequest reuse permissionsArticle Views294Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
IL233, A Novel IL-2 and IL-33 Hybrid Cytokine, Ameliorates Renal Injury (2017)

CD4<sup>+</sup>Foxp3<sup>+</sup> regulatory T cells (Tregs) protect the kidney during AKI. We previously found that IL-2, which is critical for Treg homeostasis, upregulates the IL-33 receptor (ST2) on CD4<sup>+</sup> T cells, thus we hypothesized that IL-2 and IL-33 cooperate to enhance Treg function. We found that a major subset of Tregs in mice express ST2, and coinjection of IL-2 and IL-33 increased the number of Tregs in lymphoid organs and protected mice from ischemia-reperfusion injury (IRI) more efficiently than either cytokine alone. Accordingly, we generated a novel hybrid cytokine (IL233) bearing the activities of IL-2 and IL-33 for efficient targeting to Tregs. IL233 treatment increased the number of Tregs in blood and spleen and prevented IRI more efficiently than a mixture of IL-2 and IL-33. Injection of IL233 also increased the numbers of Tregs in renal compartments. Moreover, IL233-treated mice had fewer splenic Tregs and more Tregs in kidneys after IRI. <i>In vitro</i>, splenic Tregs from IL233-treated mice suppressed CD4<sup>+</sup> T cell proliferation better than Tregs from saline-treated controls. IL233 treatment also improved the ability of isolated Tregs to inhibit IRI in adoptive transfer experiments and protected mice from cisplatin- and doxorubicin-induced nephrotoxic injury. Finally, treatment with IL233 increased the proportion of ST2-bearing innate lymphoid cells (ILC2) in blood and kidneys, and adoptive transfer of ILC2 also protected mice from IRI. Thus, the novel IL233 hybrid cytokine, which utilizes the cooperation of IL-2 and IL-33 to enhance Treg- and ILC2-mediated protection from AKI, bears strong therapeutic potential.
Monitoring protein stability in vivo (2005)

Reduced protein stability in vivo is a prerequisite to aggregation. While this is merely a nuisance factor in recombinant protein production, it holds a serious impact for man. This review focuses on specific approaches to selectively determine the solubility and/or stability of a target protein within the complex cellular environment using different detection techniques. Noninvasive techniques mapping folding/misfolding events on a fast time scale can be used to unravel the complexity and dynamics of the protein aggregation process and factors altering protein solubility in vivo. The development of approaches to screen for folding and solubility in vivo should facilitate the identification of potential components that improve protein solubility and/or modulate misfolding and aggregation and may provide a therapeutic benefit.
Chronic, cortex-wide imaging of specific cell populations during\n behavior (2020)

Measurements of neuronal activity across brain areas are important for\nunderstanding the neural correlates of cognitive and motor processes like\nattention, decision-making, and action selection. However, techniques that\nallow cellular resolution measurements are expensive and require a high degree\nof technical expertise, which limits their broad use. Widefield imaging of\ngenetically encoded indicators is a high throughput, cost effective, and\nflexible approach to measure activity of specific cell populations with high\ntemporal resolution and a cortex-wide field of view. Here we outline our\nprotocol for assembling a widefield setup, a surgical preparation to image\nthrough the intact skull, and imaging neural activity chronically in behaving,\ntransgenic mice that express a calcium indicator in specific subpopulations of\ncortical neurons. Further, we highlight a processing pipeline that leverages\nnovel, cloud-based methods to analyze large-scale imaging datasets. The\nprotocol targets labs that are seeking to build macroscopes, optimize surgical\nprocedures for long-term chronic imaging, and/or analyze cortex-wide neuronal\nrecordings.\n
Mexiletine in Myotonic Dystrophy Type 1 (2020)

This study provides Class I evidence that for ambulatory patients with DM1, mexiletine does not significantly change 6-minute walk distance at 6 months.
Clinical impact of bile‐derived exosomal microRNAs as novel diagnostic and prognostic biomarkers for biliary tract cancers (2022)

Sampling of bile juice during endoscopic retrograde cholangiopancreatography (ERCP) has potential benefit of being amenable to the identification of novel biomarkers in liquid biopsy. This study reports the results of a global investigation of exosomal microRNAs (miRNAs) in bile to identify potential biomarkers for biliary tract cancers (BTCs). Eighty-eight bile samples collected during ERCP (45 BTC and 43 noncancer control samples) were enrolled in this study. Eleven BTC samples and nine control samples were assigned as the discovery set. Exosomes in bile and serum samples were collected using a glass membrane column with size-controlled macroporous glass (MPG), and exosomal miRNA expression profiles were evaluated using comprehensive miRNA microarray analysis (3D-Gene). For validation, exosomal miRNA in the bile samples of 34 BTCs and 34 controls were comprehensively evaluated using 3D-Gene. In the discovery set, eight exosomal miRNAs in bile were identified as significant aberrant expression markers, while no miRNA with aberrant expression in serum was identified. In a comparison of the discovery and validation sets, miR-451a and miR-3619-3p were identified as reproducible upregulated markers, and the combination of the two bile miRNAs showed an excellent area under the curve (0.819) value for diagnosing BTCs. In addition, high miR-3619-3p expression in bile reflects poorer prognosis of BTCs (hazard ratio = 2.89). The MPG-extracted exosomal miRNAs in bile aspirated during ERCP provide a convenient new approach for diagnosing biliary diseases. Bile-derived miRNA analysis with miR-451a and miR-3619-3p represents a potentially valuable diagnostic strategy for identifying BTCs as well as a predictive indicator of BTC prognosis.
Long-wave IR chemical sensing based on difference frequency generation in orientation patterned GaAs (2002)

Lightsources employing quasiphasematched (QPM) nonlinear materials have demonstrated unique attributes for chemical sensing in the near- to mid-infrare spectral range (1 - 5 micrometers ). The advent of patterned-growth GaAs allows the first practical extension of QPM materials to operation in the long-wave IR (5 - 12 micrometers ). That wavelength range is particularly attractive for chemical sensing because it contains an atmospheric window, many molecular groups absorb there at distinct frequencies, and their absorptions tend to be strong relative to those in the near- and mid-IR. Here, the application of orientation-patterned GaAs (OPGaAs) for use in a continuous wave (cw) difference frequency spectrometer is described. The outputs of two external- cavity diode lasers operating in the 1.3 and 1.5 micrometers telecom bands are mixed in a OPGaAs crystal, producing tunable radiation at wavelengths near 8 micrometers . The application of the source to the measurement of a water vapor rovibrational absorption line is presented.
Accelerating FPGA routing using architecture-adaptive A* techniques (2006)

The A* algorithm is a well-known path-finding technique that is used to speed up FPGA routing. Previously published A*-based techniques are either targeted to a class of architecturally similar devices, or require prohibitive amounts of memory to preserve architecture adaptability. This work presents architecture-adaptive A* techniques that require significantly less memory than previously published work. Our techniques are able to produce routing runtimes that are within 7% (on an island-style architecture) and 9% better (on a hierarchical architecture) than targeted heuristic techniques. Memory improvements range between 30/spl times/ (island-style) and 140/spl times/ (hierarchical architecture).
Data Supplement from Genomic and Transcriptional Alterations in Lung Adenocarcinoma in Relation to Smoking History (2023)

&lt;p&gt;Supplementary Figure S5. Principal component analysis of the TCGA and Chitale et al. transcriptional cohorts showing the variance in gene expression associated with clinicopathological factors and gene expression phenotypes.&lt;/p&gt;
Quetiapine Extended Release Open-Label Treatment Associated Changes in Amygdala Activation and Connectivity in Anxious Depression (2016)

Quetiapine XR effects in the treatment of AMDD are associated with modulation of amygdala connectivity.
Thermodynamics of Ion Pair Formations Between Charged Poly(Amino Acid)s (2015)

Electrostatic interactions between the positively and negatively charged amino acids in proteins play an important role in macromolecular stability, binding, and recognition. Numerous amino acids in proteins are ionizable and may exist in negatively (e.g., Glu, Asp, Cys, Tyr) or positively (e.g., Arg, Lys, His, Orn) charged form dependent on pH and their pKas. In this work, isothermal titration calorimetry was used to determine the average standard values of thermodynamic parameters (the Gibbs free energy, enthalpy, entropy, and the heat capacity) of interaction between the positively charged amino acid homopolymers (polyarginine, polylysine, and polyornithine) and the negatively charged homopolymers (polyaspartic and polyglutamic acids). These values are of potential use in the computational models of interacting proteins and other biological macromolecules. The study showed that oppositely charged poly(amino acid)s bound each other with the stoichiometry of one positive to one negative charge. Arginine bound to the negatively charged amino acids with exothermic enthalpy and higher affinity than lysine. This result also suggests that positive charges in proteins should not be considered entirely equivalent if carried by lysine or arginine. The difference in binding energy of arginine and lysine association with the negatively charged amino acids was attributed to the enthalpy of the second ionic hydrogen bond formation between the guanidine and carboxylic groups. Despite the favorable enthalpic contribution, all such ion pair formation reactions were largely entropy-driven. Consistent with previously observed ionic interactions, the positive heat capacity was always observed during the amino acid ion pair formation.
An Integrated Framework for Evaluating Leaching in Waste Management and Utilization of Secondary Materials (2002)

A framework for the evaluation of inorganic constituent leaching from wastes and secondary materials is presented. The framework is based on the measurement of intrinsic leaching properties of the material in conjunction with mathematical modeling to estimate release under field management scenarios. Site-specific and default scenarios are considered, which may be selected based on the evaluation context. A tiered approach is provided to allow the end user to balance between the specificity of the release estimate, the amount of testing knowledge required, a priori knowledge, and resources required to complete an evaluation. Detailed test methodologies are provided for a suite of laboratory leaching tests.
Maximum likelihood tracking of a personal dead-reckoning system (2015)

We consider the problem of a human-following robot in which a human is equipped with a low-fidelity odometry sensor and a robot follows the human leader - often lagging well behind and out of visual contact with the human. The challenge is for the robot to determine the path taken by the human, despite the relatively noisy odometry data available. Such a system is useful in a “pack mule” application, where the robot carries a heavy load for the human. Our key idea is to equip the robot with sensors allowing it to build a map, and to use observations of the environment structure to constrain the path of the human. We propose and evaluate several approaches: a particle filter method that extends monte-carlo localization approaches, and a multi-hypothesis maximum-likelihood approach based on stochastic gradient descent optimization that efficiently clusters similar trajectories. We demonstrate that our proposed approaches are able to track human trajectories in several synthetic and real-world datasets.
An Integrated Global GIS and Visual Simulation System (1997)

This paper reports on an integrated visual simulation system supporting visualization of global multiresolution terrain elevation and imagery data, static and dynamic 3D objects with multiple levels of detail, non-protrusive features such as roads and rivers, distributed simulation and real-time sensor input, and an embeddedgeographic information system. The requirements of real-time rendering, very large datasets, and heterogeneous detail management strongly affect the structure of this system. Use of hierarchical spatial data structures and multiple coordinate systems allow for visualization and manipulation of huge terrain datasets spanning the entire surface of the Earth at resolutions well below one meter. The multithreaded nature of the system supports multiple windows with independent, stereoscopic views. The system is portable, built on OpenGL, POSIX threads, and X11/Motif windowed interface. It has been tested and evaluated in the field with a variety of terrain data, updates ...
S4‐02‐02: Cerebrospinal fluid biomarker standardization efforts (2012)

Cerebrospinal fluid (CSF) biomarkers are increasingly recognized for their capacity to monitor key pathological hallmarks of Alzheimer's disease (AD). A large number of single-center and multi-center studies have shown that CSF concentrations of beta-amyloid42, tau and phosphorylated-tau are altered in AD dementia, and a growing number of studies confirm that these biomarker changes are evident already at pre-dementia clinical stages. However, as for other biomarker modalities, CSF biomarker research has encountered problems of measurement variability. This is related to factors within and between laboratories, and to the performance of the technologies used for the measurements. Because of this, multi-center initiatives have been launched to study measurement variability and devise strategies to overcome them. The Alzheimer's Association External Quality Control Program was initiated in 2009, with the aim to monitor CSF measurements. The program is open for any research, clinical or industry laboratory using commercially available assays for CSF beta-amyloid or tau. The results from the first two rounds of the program have been reported previously (Mattsson N et al. Alzheimers Dement 2011;7(4):386-395). The program has continued with several rounds each year, and has included a survey of procedures at participating laboratories. It has also recently been extended with novel initiatives for measurement standardization, based on the construction of certified reference systems. Here, we present detailed results from the first eight rounds of the program. These include three samples per round analyzed at 70 labs worldwide, and the results from a survey of laboratory procedures. We also present a novel project for construction of an international certified reference material for CSF measurements, aiming at reducing variability of CSF biomarkers in clinical and research settings. The Alzheimer's Association External Quality Control Program for CSF biomarkers has established a solid platform for monitoring measurement variability, and also provides the possibility to directly explore factors contributing to variability, and implement strategies to overcome them.
Epitaxial growth of hyperbranched Cu/Cu2O/CuO core-shell nanowire heterostructures for lithium-ion batteries (2015)

The careful design of nano-architectures and smart hybridization of expected active materials can lead to more advanced properties. Here we have engineered a novel hierarchical branching Cu/Cu2O/CuO heteronanostructure by combining a facile hydrothermal method and subsequent controlled oxidation process. The fine structure and epitaxial relationship between the branches and backbone are investigated by high-resolution transmission electron microscopy. Moreover, the evolution of the branch growth has also been observed during the gradual oxidation of the Cu nanowire surface. The experimental results suggest that the surface oxidation needs to be performed via a two-step exposure process to varying humidity in order to achieve optimized formation of a core-shell structured branching architecture. Finally, a proof-of-concept of the function of such a hierarchical framework as the anode material in lithium-ion batteries is demonstrated. The branching core-shell heterostructure improves battery performance by several means: (i) The epitaxially grown branches provide a high surface area for enhanced electrolyte accessibility and high resistance to volume change induced by Li+ intercalation/extraction; (ii) the core-shell structure with its well-defined heterojunction increases the contact area which facilitates effective charge transport during lithiation; (iii) the copper core acts as a current collector as well as providing structural reinforcement.
Reciprocity for Care: Gift Giving in the Patient-Nurse Relationship (1989)

Caring for patients frequently requires intensely personal and intimate tasks to be performed by nurses. In their professional role, nurses are relative strangers to the patient, yet are responsible for providing support to patients in their most distressing moments, such as when they are in pain or facing the fear of death. Nurses also provide patients with such care or treatments as assisting with bedpans, bathing or catheterization, that would in other circumstances be considered shameful and private to the patients. Although these procedures are expected and routine nursing tasks, they rarely become expected and accepted by the patients themselves. Patients frequently apologize and express shame at the created by the loss of bodily control.
Nurses work for the hospital, yet they give care to the patient. In this article I will argue that this situation creates an imbalance in the nurse-patient relationship. It creates a loss of power, dependency and passivity within the patient, and a feeling of being obligated to reciprocate for the care given. Chapman (1976, 1980), Dowd (1975) and Kayser-Jones (1979, 1981) note that reciprocity is an essential part of the therapeutic process, although, ironically, the practice is discouraged in health care. As the nurse's employer considers that the nurse has already been reimbursed adequately in the form of salary, and recognizes the more powerful position of the nurse and the potential for exploitation, administrative policy frequently is developed to prohibit gift giving. I suggest that such a policy inhibits patient recovery and that the constant refusal results in a double-bind situation for nurses. The nurses are placed in a situation whereby they must choose between accepting or refusing the gift. The former involves breaking hospital rules with the subsequent feeling of guilt and the possibility of reprimand; the latter violates social norms (i.e., it is considered rude) and may be construed as
Scattering Of Light By A Coated Bubble In Water Near The Critical And Brewster Scattering Angles (1988)

A microbubble in the ocean may be coated by a thin film sorbed onto its surface. We identify scattering features which should be useful for the optical characterization of the bubble size and film thickness. We investigated theoretical scattering patterns for spherical gas bubbles coated by films of uniform thickness h. The patterns were computed for bubbles of various radii in the range 7 to 190 gm with h from 0.2 to 3 &mu;m. The emphasis was on the near-critical-angle and near-Brewster-angle scattering regions where regular features are attributable to the reflection properties of the bubble.
Multi view image surveillance and tracking (2003)

The paper presents a set of methods for multi view image tracking using a set of calibrated cameras. We demonstrate how effective the approach is for resolving occlusions and tracking objects between overlapping and non-overlapping camera views. Moving objects are initially detected using background subtraction. Temporal alignment is then performed between each video sequence in order to compensate for the different processing rates of each camera. A Kalman filter is used to track each object in 3D world coordinates and 2D image coordinates. Information is shared between the 2D/3D trackers of each camera view in order to improve the performance of object tracking and trajectory prediction. The system is shown to be robust in resolving dynamic and static object occlusions. Results are presented from a variety of outdoor surveillance video sequences.
Effect of Nanoclay on the Mechanical, Thermal, and Water Absorption Properties of an UP-toughened Epoxy Network (2015)

Unsaturated polyester (UP)-toughened epoxy nanocomposites were prepared, and their effective mechanical and thermal properties were studied. Two types of organo-modified montmorillonite (OMMT) clays were used to prepare the nanocomposites. X-ray diffraction (XRD) and transmission electron microscopy (TEM) analysis showed the formation of exfoliated silicate layers in the UP-toughened epoxy matrix. Mechanical tests revealed that nanocomposites (containing 1 wt% OMMT clay) showed an increase in tensile strength to 13.8%, flexural strength to 10%, and impact strength to 4% compared with an UP-toughened epoxy blend. The effect of different heating rates on the curing behavior of UP-toughened epoxy nanocomposites was investigated using non-isothermal differential scanning calorimetry. The data were interpreted using the Kissinger and Flynn–Wall–Ozawa models to find the curing reaction parameter. The water uptake behavior for nanocomposites increased with the addition of OMMTs. Scanning electron microscopy micrographs indicated morphological changes in the impact fractured samples of UP-toughened epoxy nanocomposites.