gebhart/patrepeval huggingface dataset:
Impact of Aging on the Angiogenic Potential of the Myocardium: Implications for Angiogenic Therapies with Emphasis on Sirtuin Agonists (2009)

The mechanisms for decreased tolerance to ischemia in the aging hearts have not been fully explored but they appear to be multifactorial. The elderly patients most often meet classification of "no-option" patients who suffer from symptoms of chronic recurrent myocardial ischemia without good options for intervention. As such these patients are in greatest need of alternative therapies for revascularization such as angiogenesis. Not only does aging and their co-morbid conditions such as hypercholesterolemia and diabetes impair the endogenous angiogenesis response but there may be decreased responsiveness to exogenous angiogenic therapies. Enhancing the effectiveness of angiogenic therapy in this ever increasing subgroup of cardiovascular patients is as yet unmet. One such promising avenue involves sirtuins. Herein, we review the effect of aging on the processes of angiogenesis and explore the implications for successful clinical treatment of myocardial ischemia with angiogenesis therapy, with particular focus on modification of sirtuins and their targets by resveratrol along with some recent patents.
A critical role for HER3 in HER2-amplified and non-amplified breast cancers: function of a kinase-dead RTK. (2015)

ERBB3/HER3 is the most intriguing RTK by virtue of its ability to transduce multiple cytosolic signals for the proliferation and growth of tumor cells in spite of being a "kinase dead" receptor that binds to its true ligand, heregulin. Although other members of the HER3 family like EGFR and HER2 have long been recognized to be associated with breast tumorigenesis and studied because of their predictive and prognostic value, the significance of HER3 as an irrefutable component of HER family signalosome is a relatively new development. The recent understanding of signals originating from the oncogenic partnership of HER3 with HER2 in the context of HER2 amplification/overexpression showed the critical clinical value for the treatment of HER2+BC. The downstream signaling cascade (included but not limited to the PI3K signaling) associated with signals originating from HER2:HER3 dimers play a vital role in the tumorigenesis, drug-resistance and tumor progression of HER2+BC. The upregulation of HER3 activity provides an alternate "escape route" via which tumor cells bypass either the inhibition of the HER family RTKs or the inhibition of the downstream PI3K-AKT-mTOR signaling pathway. By understanding the signaling that provides this "escape route" for these tumor cells treated with a targeted therapy (HER2 inhibitors or inhibitors of downstream PI3K-AKT-mTOR signaling pathway), we are just beginning to appreciate the prognostic value of HER3 in breast cancer. In this review, we will discuss the relevance of HER3 signaling in the context of, (1) downstream oncogenic signals and (2) therapeutic options in HER2 amplified BC.
Measurements on real-time performance of a token ring network (1990)

Real-time applications, such as manufacturing or process control, impose stringent requirements on communication networks with respect to the properties of timeliness and robustness. These properties are determined first by the efficiency of the protocols and second by the efficiency and scope of the recovery mechanisms. The measurement study presented was carried out in a testbed based on a 4-Mbit/s ISO 8802/5 token ring network. Measurements characterizing the network's error recovery performance, as well as its user-related delay performance, are presented. Both types of performance data are required to evaluate a network in terms of real-time criteria, such as the submission of a data packet to a defined deadline. As a particular result, measurements on priority operation of the network show that for a small number of stations differences in service between priority and nonpriority traffic predominantly occur at extremely high network loads.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Evidence that the Mouse Osteocalcin-Related Gene Does Not Encode Nephrocalcin (2006)

We conclude that ORG, the third gene of the mouse osteocalcin gene cluster is silent and unlikely to play a major role in mouse renal physiology.
DFB Quantum Cascade Laser Arrays (2009)

DFB quantum cascade laser (DFB-QCL) arrays operating between 8.7 and 9.4 mum are investigated for their performance characteristics-single-mode selection of the DFB grating, and variability in threshold, slope efficiency, and output power of different lasers in the array. Single-mode selection refers to the ability to choose a desired mode/frequency of laser emission with a DFB grating. We apply a theoretical framework developed for general DFB gratings to analyze DFB-QCL arrays. We calculate how the performance characteristics of DFB-QCLs are affected by the coupling strength kappaL of the grating, and the relative position of the mirror facets at the ends of the laser cavity with respect to the grating. We discuss how single-mode selection can be improved by design. Several DFB-QCL arrays are fabricated and their performance examined. We achieve desired improvements in single-mode selection, and we observe the predicted variability in the threshold, slope efficiency, and output power of the DFB-QCLs. As a demonstration of potential applications, the DFB-QCL arrays are used to perform infrared absorption spectroscopy with fluids.
How noise propagates from camera sensor to displacement and strain maps obtained with the grid method (2014)

International audience
A correlation study between photodegradation and material quality in amorphous silicon p-i-n solar cells (2002)

In this work the authors focused on the possibility to derive correlations between p-i-n solar cells degradation and the material deposited inside the p-i-n, employing a capacitance versus frequency technique. Results obtained with this technique have been compared with those obtained by standard I-V characterization, and a complete picture of the density of states during light soaking has been obtained. This has been finally correlated with the initial features of the device. As a result, evidence of the presence of either neutral dangling bonds or quasi-shallow traps has been found. Degradation due to light soaking can be interpreted by a consistent increase of deep defects together with a much lighter effect on quasi-shallow defects.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Gossip Latin Square and The Meet-All Gossipers Problem. (2013)

Given a network of n = 2 k gossipers, we want to schedule a cyclic calendar of meetings between all of them, such that: (1) each gossiper communicates (gossips) only once a day, with one other gossiper, (2) in every (n−1) consecutive days, each gossiper meets all other gossipers, and (3) every gossip, initiated by any gossiper, will reach all gossipers within k = log(n) days. In this paper we study the above stated meet-all gossipers problem, by defining and constructing the Gossip Latin Square (GLS), a combinatorial structure which solves the problem. Keywords: Latin square, gossip
A new measurement system with a virtual gray level pattern (2002)

In this paper, an equivalent gray level pattern with a small period has been proposed, based on the concept of geometrical variety and associated with the manufacturing process of a semiconductor optical mask. High precision displacement measurement is achieved by a phase-detecting technology. The experimental results show that the concept is feasible.
Fragment-Based Drug Discovery Applied to Hsp90. Discovery of Two Lead Series with High Ligand Efficiency (2010)

Inhibitors of the chaperone Hsp90 are potentially useful as chemotherapeutic agents in cancer. This paper describes an application of fragment screening to Hsp90 using a combination of NMR and high throughput X-ray crystallography. The screening identified an aminopyrimidine with affinity in the high micromolar range and subsequent structure-based design allowed its optimization into a low nanomolar series with good ligand efficiency. A phenolic chemotype was also identified in fragment screening and was found to bind with affinity close to 1 mM. This fragment was optimized using structure based design into a resorcinol lead which has subnanomolar affinity for Hsp90, excellent cell potency, and good ligand efficiency. This fragment to lead campaign improved affinity for Hsp90 by over 1,000,000-fold with the addition of only six heavy atoms. The companion paper (DOI: 10.1021/jm100060b) describes how the resorcinol lead was optimized into a compound that is now in clinical trials for the treatment of cancer.
Chronological Self-Training for Real-Time Speaker Diarization (2021)

Diarization partitions an audio stream into segments based on the voices of the speakers. Real-time diarization systems that include an enrollment step should limit enrollment training samples to reduce user interaction time. Although training on a small number of samples yields poor performance, we show that the accuracy can be improved dramatically using a chronological self-training approach. We studied the tradeoff between training time and classification performance and found that 1 second is sufficient to reach over 95% accuracy. We evaluated on 700 audio conversation files of about 10 minutes each from 6 different languages and demonstrated average diarization error rates as low as 10%.
Combining statistical alignment and phylogenetic footprinting to detect regulatory elements (2008)

SAPF is freely available to download online at http://www.stats.ox.ac.uk/~satija/SAPF/
Numerical deconvolution by a Monte Carlo approach with application to dynamic cardiac perfusion Tc-99m SPECT (2001)

Accurate determination of the input function is essential for absolute quantification of physiological parameters in PET and SPECT imaging but it requires an invasive and tedious procedure of blood sampling that is impractical in clinical studies. We previously proposed a technique that simultaneously estimates kinetic parameters and the input function from the tissue impulse response functions and which, requires only two blood samples. A nonlinear least squares method was used to estimate all the parameters in the impulse response functions and the input function but it fails occasionally due to high noise levels in the data causing an ill-conditioned cost function. This study investigates the feasibility of applying a Monte Carlo method called simulated annealing to estimate kinetic parameters in the impulse response functions and the input function. Time-activity curves of teboroxime, which is very sensitive to changes in the input function, were simulated based on published data obtained from a canine model. The equations describing the tracer kinetics in different regions were minimised simultaneously by simulated annealing and nonlinear least squares. We found that the physiological parameters obtained with simulated annealing are more accurate and the estimated input function more closely resembled the simulated curve. We conclude that simulated annealing reduces bias in the estimation of physiological parameters and determination of the input function.
Investigation of Polystyrene-Poly(ethylene oxide) Block Copolymer Micelle Formation in Organic and Aqueous Solutions by Nonradiative Energy Transfer Experiments (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInvestigation of Polystyrene-Poly(ethylene oxide) Block Copolymer Micelle Formation in Organic and Aqueous Solutions by Nonradiative Energy Transfer ExperimentsF. Calderara, Z. Hruska, G. Hurtrez, J. P. Lerch, T. Nugay, and G. RiessCite this: Macromolecules 1994, 27, 5, 1210–1215Publication Date (Print):February 1, 1994Publication History Published online1 May 2002Published inissue 1 February 1994https://pubs.acs.org/doi/10.1021/ma00083a020https://doi.org/10.1021/ma00083a020research-articleACS PublicationsRequest reuse permissionsArticle Views385Altmetric-Citations65LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Combination therapy with the CDK7 inhibitor and the tyrosine kinase inhibitor exerts synergistic anticancer effects against MYCN‐amplified neuroblastoma (2020)

Patients with neuroblastoma due to MYCN oncogene amplification and consequent N-Myc oncoprotein overexpression have very poor prognosis. The cyclin-dependent kinase 7 (CDK7)/super-enhancer inhibitor THZ1 suppresses MYCN gene transcription, reduces neuroblastoma cell proliferation, but does not cause significant cell death. The protein kinase phosphatase 1 nuclear targeting subunit (PNUTS) has recently been shown to interact with c-Myc protein and suppresses c-Myc protein degradation. Here we screened the U.S. Food and Drug Administration-Approved Oncology Drugs Set V from the National Cancer Institute, and identified tyrosine kinase inhibitors (TKIs), including ponatinib and lapatinib, as the Approved Oncology Drugs exerting the best synergistic anticancer effects with THZ1 in MYCN-amplified neuroblastoma cells. Combination therapy with THZ1 and ponatinib or lapatinib synergistically induced neuroblastoma cell apoptosis, while having little effects in normal nonmalignant cells. Differential gene expression analysis identified PNUTS as one of the genes most synergistically reduced by the combination therapy. Reverse transcription polymerase chain reaction and immunoblot analyses confirmed that THZ1 and the TKIs synergistically downregulated PNUTS mRNA and protein expression and reduced N-Myc protein but not N-Myc mRNA expression. In addition, PNUTS knockdown resulted in decreased N-Myc protein but not mRNA expression and decreased MYCN-amplified neuroblastoma cell proliferation and survival. As CDK7 inhibitors are currently under clinical evaluation in patients, our data suggest the addition of the TKI ponatinib or lapatinib in CDK7 inhibitor clinical trials in patients.
Pyrazolo[3,4‐e] [1,4] thiazepines: Synthesis and structure proof (1975)

Abstract Pyrazolo[3,4‐ e ][1,4]thiazepine derivatives were obtained by reacting 5‐amino‐1,3‐dimethylpyrazole with arylaldehydes or ketones and mercaptoacetic acid. The structure proof of these derivatives was carried out by identifying the benzylpyrazole products obtained by desulfurization and subsequent hydrolysis, and by comparison of the spectral data of a series of analogous pyrazolothiazepines. Treating the pyrazolothiazepines with sodium hydride and methyl iodide in dimethylformamide or dimethylsulfoxide resulted in a ring contraction with the elimination of sulfur, to yield the pyrazolopyridones in addition to the N ‐methylpyrazolothiazepines.
Intravesical Bacillus Calmette-Guerin Reduces the Risk of Progression in Patients with Superficial Bladder Cancer: A Meta-analysis of the Published Results of Randomized Clinical Trials (2002)

Intravesical BCG significantly reduces the risk of progression after transurethral resection in patients with superficial bladder cancer who receive maintenance treatment. Thus, it is the agent of choice for patients with intermediate and high risk papillary tumors and those with carcinoma in situ.
HDPE Barrier Film Resins - MW and MWD Effects - and their Blends with mLLPDE (2002)

High density polyethylene (HDPE) resins were produced via the multi-reactor, Mitsui, stirred slurry process to give a `four corners' type of product matrix with high and low molecular weights (MW) and broad and narrow molecular weight distributions (MWDs). Density was kept constant. Film processing and physical properties - including oxygen, carbon dioxide, and water vapor transmission rates - are presented. Lower MW and narrower MWD favor better barrier properties. The best barrier HDPE resin was blended with mLLDPE and films blown from these blends demonstrated the potential for application specific film strength and optical property tailoring while maintaining high barrier performance.
HYBRIDIZATION AND SPECIATION IN FOSSORIAL MOLE RATS (1976)

Journal Article HYBRIDIZATION AND SPECIATION IN FOSSORIAL MOLE RATS Get access Eviatar Nevo, Eviatar Nevo Department of Biology University of Haifa Haifa Israel Search for other works by this author on: Oxford Academic Google Scholar Hana Bar‐El Hana Bar‐El Department of Biology University of Haifa Haifa Israel Search for other works by this author on: Oxford Academic Google Scholar Evolution, Volume 30, Issue 4, 1 December 1976, Pages 831–840, https://doi.org/10.1111/j.1558-5646.1976.tb00964.x Published: 01 December 1976 Article history Received: 13 October 1975 Revision received: 02 March 1976 Published: 01 December 1976
A new phase transitions for local delays in MANETs (2010)

We study a slotted version of the Aloha Medium Access (MAC) protocol in a Mobile Ad-hoc Network (MANET). Our model features transmitters randomly located in the Euclidean plane, according to a Poisson point process and a set of receivers representing the next-hop from every transmitter. We concentrate on the so-called outage scenario, where a successful transmission requires a Signal-to-Interference-and-Noise (SINR) larger than some threshold. We analyze the local delays in such a network, namely the number of times slots required for nodes to transmit a packet to their prescribed next-hop receivers. The analysis depends very much on the receiver scenario and on the variability of the fading. In most cases, each node has finite-mean geometric random delay and thus a positive next hop throughput. However, the spatial (or large population) averaging of these individual finite mean-delays leads to infinite values in several practical cases, including the Rayleigh fading and positive thermal noise case. In some cases it exhibits an interesting phase transition phenomenon where the spatial average is finite when certain model parameters (receiver distance, thermal noise, Aloha medium access probability) are below a threshold and infinite above. To the best of our knowledge, this phenomenon, which we propose to call the wireless contention phase transition, has not been discussed in the literature. We comment on the relationships between the above facts and the heavy tails found in the so-called "RESTART" algorithm. We argue that the spatial average of the mean local delays is infinite primarily because of the outage logic, where one transmits full packets at time slots when the receiver is covered at the required SINR and where one wastes all the other time slots. This results in the "RESTART" mechanism, which in turn explains why we have infinite spatial average. Adaptive coding offers another nice way of breaking the outage/RESTART logic. We show examples where the average delays are finite in the adaptive coding case, whereas they are infinite in the outage case.
Erythrolic acids A–E, Meroterpenoids from a Marine-DerivedErythrobactersp. (2012)

Erythrolic acids A-E (1-5) are five unusual meroterpenoids isolated from the bacterium Erythrobacter sp. derived from a marine sediment sample collected in Galveston, TX. The structures were elucidated by means of detailed spectroscopic analysis and chemical derivatization. The erythrolic acids contain a 4-hydroxybenzoic acid appended with a modified terpene side chain. The side-chain modifications include oxidation of a terminal methyl substituent and in the case of 1-4 addition of a two-carbon unit to give terpene side chains of unusual length: C22 for 1 and 2, C17 for 3, and C12 for 4. The relative and absolute configurations of the meroterpenoids were determined by coupling constant, NOE, and Mosher's analysis. In vitro cytotoxicity toward a number of nonsmall cell lung cancer (NSCLC) cell lines revealed only modest activity for erythrolic acid D (4) (2.5 μM against HCC44). The discovery of these unusual diterpenes, along with the previously reported erythrazoles, demonstrates the natural product potential of a previously unstudied group of bacteria for drug discovery. The unusual nature of the terpene side chain, we believe, involves an oxidation of a terminal methyl group to a carboxylic acid and subsequent Claisen condensation with acetyl-CoA.
Secure/Multipurpose Internet Mail Extensions (S/MIME) Version 3.2 Message Specification (2010)

This document defines Secure/Multipurpose Internet Mail Extensions (S/MIME) version 3.2.S/MIME provides a consistent way to send and receive secure MIME data.Digital signatures provide authentication, message integrity, and non-repudiation with proof of origin.Encryption provides data confidentiality.Compression can be used to reduce data size.This document obsoletes RFC 3851.
Asymptomatic Liver Abscesses Mimicking Metastases in Patients after Whipple Surgery: Infectious Complications following Percutaneous Biopsy—A Report of Two Cases (2012)

We present two cases of hepatic abscesses that mimicked metastases in patients having undergone Whipple surgery. Both patients had similar imaging features on computed tomographic (CT) scan and ultrasound, and at the time of referral for biopsy neither patient was clinically suspected to have liver abscess. Both patients underwent biopsy of liver lesions and developed postprocedural infectious complications.
On Quantified Modal Theorem Proving for Modeling Ethics (2019)

In the last decade, formal logics have been used to model a wide range of ethical theories and principles with the goal of using these models within autonomous systems. Logics for modeling ethical theories, and their automated reasoners, have requirements that are different from modal logics used for other purposes, e.g. for temporal reasoning. Meeting these requirements necessitates investigation of new approaches for proof automation. Particularly, a quantified modal logic, the deontic cognitive event calculus (DCEC), has been used to model various versions of the doctrine of double effect, akrasia, and virtue ethics. Using a fragment of DCEC, we outline these distinct characteristics and present a sketches of an algorithm that can help with some aspects proof automation for DCEC.
Study of Broadband/Dual-band Stack Prism Absorber (2020)

This paper presents a simulation-based study of multilayered absorbers. Such absorber structures can be designed to exhibit broadband absorption performance of 52% fractional bandwidth. We discuss the TE, TM incidence angle dependency characteristics of a doubly periodic arrangement of the square, conical and hexagonal truncated stacked lamination prism arrays. Then further geometry modification is made to achieve a dual-band operation with a low profile. The simulation results show that the frequency ratio can be tuned by controlling the metallic via location. The resultant dual-band design has stable absorption performance at different incident angles.