gebhart/patrepeval huggingface dataset:
Collagen in the Developing Larynx (1992)

The primary purpose of this study was to determine the types of collagen in the developing human larynx that contribute to the structural framework and function of various components of this organ. The infant larynx is much more than a mere miniature of the adult "voice box." There are many age-related differences that occur in the larynx from the newborn period to the adult period of life. While collagen has been studied in numerous tissues, both normal and diseased, there have been no studies of the whole organ content, types, and/or changes of collagen in the developing human larynx that may account for many of the clinical findings. This study may at least in part explain whether collagen differences may account for the structural changes and responses that are seen in clinical practice.
KIT Wissen - Sendung vom 24. Juli 2014 (2014)

Sendung vom 24. Juli mit Frank Winkler. Themen: Als der Regen den Hunger brachte - Landnutzung im frühen Mittelalter, Gewaltherrscher oder Reformer? - Wer war Carolus Magnus?, VIP im Mittelalter - Der große Karl privat, Optimale Lesbarkeit - Karolingische Minuskel als Vorbild der Druckschrift.
Coordination chemistry of diphenylphosphinoferrocenylthioethers on cyclooctadiene and norbornadiene rhodium(i) platforms (2012)

Complexes [RhCl(diene)(P,SR)] with chiral ferrocenyl phosphine-thioethers ligands (diene = norbornadiene, NBD, 1(R), or 1,5-cyclooctadiene, COD, 3(R); P,SR = CpFe(1,2-η(5)-C(5)H(3)(PPh(2))(CH(2)SR); R = tBu, Ph, Bz, Et) and the corresponding [Rh(diene)(P,SR)][BF(4)] (diene = NBD, 2(R); COD, 4(R)) have been synthesized from [RhCl(diene)](2) and the appropriate P,SR ligand. The molecular structure of the cationic complexes 2(tBu), 4(Ph) and 4(Bz), determined by single-crystal X-ray diffraction, shows the expected slightly distorted square planar geometry. For the neutral chloride complexes, a combination of experimental IR and computational DFT investigations points to an equally four coordinate square planar geometry with the diene ligand, the chlorine and the phosphorus atoms in the coordination sphere and with a dangling thioether function. However, a second isomeric form featuring a 5-coordinated square planar geometry with the thioether function placed in the axial position is easily accessible in some cases.
Abstract 1295: SJP1901, a small molecule inhibitor targeting hippo pathway by directly inhibiting TEAD palmitoylation in hippo pathway-dependent cancer (2021)

Abstract The hippo pathway is a critical transcriptional regulator of cell growth, proliferation, and migration in cancer, furthermore,YAP-TEAD complexes act as a major role in the pathway. S-palmitoylation of cysteine residues in TEAD proteins is required for their stability and function in hippo pathway signaling. Recently, it has become manifested that the dysregulation of hippo pathway effectors (MST1/2 and LATS1/2) is involved in oncogenesis. These effectors inactivate translocation of YAP and TAZ into the nucleus. The translocation of YAP/TAZ is responsible for acting as transcriptional coactivators by binding to the transcription factor, TEADs resulting in the transcription of cancer-related genes that drive tumor growth. Since YAP/TAZ are considered to be natively unfolded and can be difficult to handle as a drug target, TEAD is regarded as an excellent therapeutic target for intervention of the hippo pathway. SJP1901 is a small molecule of TEAD inhibitor with potential as drug candidates in malignant mesothelioma and other types of cancer. Based on the results of structure-based drug design, hit compounds were synthesized and their efficacy was evaluated.The compounds effectively inhibited palmitoylation of TEAD proteins and showed remarkable efficacy in reporter gene assay using TEAD responsive element (TRE)-integrated MCF7 with nano molar IC50 concentrations. The excellent anti-tumor effect of SJP1901 was revealed via cell proliferation inhibition assay (nano molar IC50 concentrations) andanalysis of inhibited transcription activity for target genes (CTGF and CYR61) usingmalignant mesothelia cell lines (NCI-H226, NCI-H2052 and MSTO-211H) known to display hippo pathway-dependent cell growth. In addition, these compounds showed lower toxicities in normal cells such as Fa2N4, CCD-18co and WI38 (IC50&amp;gt;10 μM). In conclusion, we obtained potent small molecules which inactivate TEAD proteins by directly inhibiting their palmitoylation. SJP1901 showed outstanding anti-cancer effects through regulating hippo pathway-mediated target genes and lower toxicitiy in normal cells. In vivo efficacy study and research to expand the indications are currently ongoing. Citation Format: Jihyun Um, Janghyun Lee, Kwangwoo Hwang, Sujin Park, Jooyoung Hyun, Dohyeong Lee, Jeongmin Lee, Li-Kyung Kim, Moon Jung Back, Seong Jun Park, Hwan Jung Lim, You-Keun Shin, Hei-Cheul Jeung, Jaewoong Lee, Hyun Tae Kim, Yongbin Park, Hoseok Kwon, Min-Hyo Ki. SJP1901, a small molecule inhibitor targeting hippo pathway by directly inhibiting TEAD palmitoylation in hippo pathway-dependent cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 1295.
VFDS (2014)

Large amounts of data often require expensive and time-consuming analysis. Therefore, highly scalable and efficient techniques are necessary to process, analyze and discover useful information. Database sampling has proven to be a powerful method to surpass these limitations. Using only a sample of the original large database brings the benefit of obtaining useful information faster, at the potential expense of lower accuracy. In this paper, we demonstrate \vfds, a novel fast database sampling system that maintains the referential integrity of the data. The system is developed over the open-source database management system, MySQL. We present various scenarios to demonstrate the effectiveness of VFDS in approximate query answering, sample size, and execution time, on both real and synthetic databases.
Determination of oxamyl residues in peppermint hay and oil using a radioisotope dilution technique (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of oxamyl residues in peppermint hay and oil using a radioisotope dilution techniqueUlo Kiigemagi, Carole J. Heatherbell, and Max L. DeinzerCite this: J. Agric. Food Chem. 1984, 32, 3, 628–633Publication Date (Print):May 1, 1984Publication History Published online1 May 2002Published inissue 1 May 1984https://pubs.acs.org/doi/10.1021/jf00123a051https://doi.org/10.1021/jf00123a051research-articleACS PublicationsRequest reuse permissionsArticle Views37Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Experimental Demonstration on the Reduction of Linewidth Impact in a Self-Heterodyne Optical OFDM System (2010)

We show experimentally that the signal quality of a self-heterodyne optical OFDM system can be improved by temporally realigning the carrier with the subcarriers before photodetection. This can be explained by self-heterodyne linewidth measurement theory.
The TRIF/TBK1/IRF-3 activation pathway is the primary inhibitory target of resveratrol, contributing to its broad-spectrum anti-inflammatory effects. (2011)

Resveratrol, a stilbene type compound identified in wine and fruit juice, has been found to exhibit various pharmacological activities such as anti-oxidative, anti-cancerous, anti-inflammatory and anti-aging effects. Although numerous papers have explored the pharmacology of resveratrol in one particular cellular action, how this compound can have multiple effects simultaneously has not been fully addressed. In this study, therefore, we explored its broad-spectrum inhibitory mechanism using lipopolysaccharide (LPS)-mediated inflammatory responses and reporter gene assays involving overexpression of toll like receptor (TLR) adaptor molecules. Co-transfection of adaptor molecules such as (1) myeloid differentiation primary response gene 88 (MyD88), (2) Toll/4ll-1 Receptor-domain-containing adapter-inducing interferon-beta (TRIF), (3) TRIF-related adaptor molecule (TRAM), or (4) TANK-binding kinase (TBK) 1 strongly enhanced luciferase activity mediated by transcription factors including nuclear factor (NF)-KB, activator protein (AP)-1, and interferon regulatory factor (IRF)-3. Of the adaptor proteins, TRIF and TBK1 but not MyD88 and IKK enhanced luciferase activity mediated by these transcription factors. Resveratrol dose-dependently suppressed LPS-induced NO production in macrophages. It also blocked the increases in levels of mRNA for IFN-1, tumor necrosis factor (TNF)-alpha, and inducible nitric oxide synthase (iNOS) that were induced by LPS. Resveratrol diminished the translocation or activation of IRF-3 at 90min, c-Jun, a subunit of AP-1, and STAT-1 at 120 min, and p50, a subunit of NF-KB, at 60 and 90 min. Resveratrol strongly suppressed the up-regulation of luciferase activity induced by these adaptor molecules with IC50 values of 5 to 65 microM. In particular, higher inhibitory effects of resveratrol were when TRIF or TBK1 were overexpressed following cotransfection of luciferase constructs with IRF-3 binding sequences. Taken together, our data suggest that the suppression of TRIF and TBK1, which mediates transcriptional activation of NF-kappaB, AP-1, and IRF-3, contributes to resveratrol's broad-spectrum inhibitory activity, and that this compound can be further developed as a lead anti-inflammatory compound.
Experimental demonstration of self-collimation in low-index-contrast photonic crystals in the millimeter-wave regime (2005)

In this paper, we present the theoretical and experimental results for self-collimation in low-index-contrast photonic crystals (PhCs) in the millimeter-wave (MMW) region of the electromagnetic spectrum. The design of the PhCs is based on their equifrequency contours and the two-dimensional finite-difference time-domain simulation results. In the experiments, the MMW PhCs are fabricated in Rexolite slabs by a CNC micro-milling system. A MMW imaging system is built based on a vector network analyzer. The input source is launched either through a waveguide or a monopole, while the field distribution is acquired by scanning a monopole antenna over the surface of the photonic crystal to detect the profile of the evanescent waves. In both cases, we have observed and characterized the self-collimation effect for both the amplitude and phase of the propagating electromagnetic wave in low-index-contrast photonic crystals.
Electrical Properties of Amorphous Silicon Transistors and MIS‐Devices: Comparative Study of Top Nitride and Bottom Nitride Configurations (1993)

The electrical properties of silicon nitride/amorphous silicon structures were investigated using thin film transistors (TFTs) and metal insulator semiconductor (MIS) devices employing either a top nitride (TN) or bottom nitride (BN) as gate insulator. The density of states (DOS) deduced from the subthreshold transfer characteristic of the TFTs is one to two orders of magnitude higher than that obtained from quasistatic C(V) measurements on the MIS structures. This difference is discussed by considering the different thickness of the a‐Si:H layers of the two devices and the role of a fixed charge at the rear interface. Both techniques indicate a DOS in BN devices which is only slightly lower than in TN devices, by less than a factor of two. The measured field effect mobility of BN TFTs is about 70% higher. The differences in the measured field effect mobility for TN and BN configuration are discussed and ascribed to the source and drain parasitic resistances. The conclusion is verified by the fabrication of a TN TFT with a pure phosphine rear surface treatment, which exhibits performance comparable to BN TFTs.
Polysaccharides in Fungi. XXXIII. Hypoglycemic Activity of an Acidic Polysaccharide (AC) from Tremella fuciformis (1994)

Glucuronoxylomannan (AC) from the fruiting bodies of Tremella fuciformis exhibited a significant dose-dependent hypoglycemic activity in normal mice and also showed a significant activity in streptozotocin-induced diabetic mice, by intraperitoneal (i.p.) administration. The activities of AC-derivatives such as a product of AC which side chains had been removed were lower than that of native AC. AC raised the plasma insulin level in normal mice. Administration of AC to normal mice significantly increased the activities of hepatic hexokinase and glucose-6-phosphatase dehydrogenase, but it decreased that of hepatic glucose-6-phosphatase. Furthermore, AC reduced the glycogen content in the liver, increased the total lipid in epididymal adipose tissue, and lowered the plasma cholesterol level. The foregoing results indicated that the hypoglycemic activity of AC in normal mice was at least responsible for the increase of insulin secretion and for the acceleration of glucose metabolism. Single oral administration at a dose of 50-300 mg/kg of AC did not affect the plasma glucose level in normal mice, but continuous oral administrations of the AC solution (0.75 g/l) instead of water for a long time was found to be effective on the plasma glucose level in both experiments of the mice injected once i.p. with streptozotocin (170 mg/kg) at 0 d of AC administration and streptozotocin-induced diabetic mice.
Pattern generator card, emulation, and debug (2002)

Details a pattern generator card used in a high speed VLSI test system, a software emulation of that card, and card debug procedure. The Advanced Test System built at IBM East Fishkill contains primarily pin electronics cards, pattern generator cards, and power and clock distribution cards. The software emulator, called PGEM, for pattern generator emulation, serves two major purposes: it facilitates off-line debug of pattern generator cards; and, when used with a waveform tool, it permits verification of test programs without wasting system time. The simplification of off-line debug is important in terms of time savings and reduction of expensive incorrect diagnoses.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Inhibitory roles of the mammalian GnIH ortholog RFRP3 in testicular activities in adult mice (2014)

The aim of this study was to evaluate the effects of in vivo and in vitro treatments with RFamide-related peptide 3 (RFRP3), a mammalian gonadotropin-inhibitory hormone ortholog, on testicular activities, i.e. spermatogenesis and steroidogenesis, in mice. Mice were treated in vivo with different doses of RFRP3 (control: 0.02 μg, 0.2 μg, and 2.0 μg/day) for 8 days. For in vitro study, the testes of mice were evaluated with different doses of RFRP3 (control: 1 and 10 ng/ml) with or without LH (control: 10 and 100 ng/ml) for 24 h at 37 °C. RFRP3 treatment produced significant changes in the body mass, circulating steroid level, and testicular activity in mice. RFRP3 treatment also caused dose-dependent histological changes in spermatogenesis, such as decline in germ cell proliferation and survival markers and increase in apoptotic markers in testis. Both in vivo and in vitro studies showed the inhibitory effect of RFRP3 on testosterone synthesis in the testis. RFRP3 inhibited the expression of the receptor for LH (LHCGR), STAR protein, cytochrome P450 side-chain cleavage (CYP11A1) and 3β-hydroxysteroid dehydrogenase in the testis, and testosterone secretion dose dependently. This study also suggested that the inhibitory effect of RFRP3 in the testis may be mediated through local production of GnRH. Thus, RFRP3 inhibits testicular steroidogenesis and spermatogenesis either indirectly through GnRH or by directly influencing germ cell proliferation, survival, and apoptosis.
Toughening of polyamide 11 via addition of crystallizable polyethylene derivatives (2009)

Abstract BACKGROUND: Conventional rubber‐like toughening modifiers are soft and amorphous, and when used to toughen polyamide 11 (PA11) they commonly induce a decrease in the tensile strength and modulus. In this study, crystallizable polyethylene (PE) derivatives, i.e. linear low‐density polyethylene (LLDPE) and maleic anhydride‐grafted polyethylene (PE‐ g ‐MA), were adopted to toughen PA11. RESULTS: Compared to pure PA11, a highest improvement by a factor of eight in the impact toughness was achieved; also, the tensile strength and modulus could be maintained at a relatively high level. PE‐ g ‐MA acted as a compatibilizer for PA11 and LLDPE, bringing strong interfacial adherence, and especially a domain‐in‐domain morphology observed in PA11/PE‐ g ‐MA/LLDPE (70/10/20 by weight) blends. The observation that PA11 was toughened by the crystallizable PE derivatives is discussed in depth, based on the combined effect of surface crystallization of LLDPE on pre‐formed PA11 crystallites and interfacial compatiblization between PA11 and PE‐ g ‐MA. CONCLUSION: The crystallizable PE derivatives LLDPE and PE‐ g ‐MA were shown to be effective toughening modifiers for the proportions PA11/PE‐ g ‐MA/LLDPE 70/10/20 (by weight), which is considered to be an optimum composition: special domain‐in‐domain morphology was observed indicating a good dispersion of PE in the PA11 matrix and strong interfacial adherence between PE phase and PA11 phase. The reason why strength and modulus were maintained at a high level in the as‐prepared blends was attributed to the existence of rigid crystalline domains in PE. Copyright © 2009 Society of Chemical Industry
Photovoltaic Materials as Heterogeneous Photocatalysts: A Golden Opportunity for Sustainable Organic Syntheses (2023)

Light absorption by semiconducting materials generates electrons and holes subsequent to charge separation, which is at the core of two different applications: 1) photovoltaics and 2) photocatalysis, intended to generate electric current or to trigger redox events, respectively. Recent developments in photovoltaic applications have been impressive, owing to the introduction of innovative and more efficient materials. This brief review describes recent examples to demonstrate the relative high performance of photovoltaic materials that have been exploited in photocatalytic synthetic applications. These include redox processes (net oxidations and reductions), CC bond formation, and manipulation of cyclic structures. Although several benchmark reactions have been explored routinely, a recent trend highlights the development of ground‐breaking synthetic applications, which demonstrate the importance of converting such highly performing materials from the photovoltaic into the photocatalytic field.
Experimental Poincare maps from the twist-and-flip circuit (1996)

We present a physical implementation of the twist-and-flip circuit containing a nonlinear gyrator. Many phase portraits and their associated Poincare maps are observed experimentally from this circuit and presented in this paper.
Reduced Graphene Oxides: Light‐Weight and High‐Efficiency Electromagnetic Interference Shielding at Elevated Temperatures (2014)

Chemical graphitized r-GOs, as the thinnest and lightest material in the carbon family, exhibit high-efficiency electromagnetic interference (EMI) shielding at elevated temperature, attributed to the cooperation of dipole polarization and hopping conductivity. The r-GO composites show different temperature-dependent imaginary permittivities and EMI shielding performances with changing mass ratio.
Dual versus triple therapy of Helicobacter pylori infection: results of a multicentre trial (1999)

Dual therapy can no longer be recommended. Triple therapy is more effective than dual therapy in the eradication of H pylori infection. The lower dose of 1 mg/kg omeprazole was as effective as 2 mg/kg.
Limited inhibition of multiple nodes in a driver network blocks metastasis (2021)

Metastasis suppression by high-dose, multi-drug targeting is unsuccessful due to network heterogeneity and compensatory network activation. Here, we show that targeting driver network signaling capacity by limited inhibition of core pathways is a more effective anti-metastatic strategy. This principle underlies the action of a physiological metastasis suppressor, Raf Kinase Inhibitory Protein (RKIP), that moderately decreases stress-regulated MAP kinase network activity, reducing output to transcription factors such as pro-metastastic BACH1 and motility-related target genes. We developed a low-dose four-drug mimic that blocks metastatic colonization in mouse breast cancer models and increases survival. Experiments and network flow modeling show limited inhibition of multiple pathways is required to overcome variation in MAPK network topology and suppress signaling output across heterogeneous tumor cells. Restricting inhibition of individual kinases dissipates surplus signal, preventing threshold activation of compensatory kinase networks. This low-dose multi-drug approach to decrease signaling capacity of driver networks represents a transformative, clinically relevant strategy for anti-metastatic treatment.
Chemotherapy for prostate carcinoma. (1988)

We have evaluated the role of chemotherapy for the treatment of prostate carcinoma. The data of patients with endocrine-resistant stage D2 disease indicate that clinical benefits in such patients are at best marginal. Despite the controversies involved in the assessment of response in this disease, in this review we show that in over 3,000 patients eligible for evaluation, less than 10% had complete or partial responses to various treatment regimens. Survival evaluation on all prospective randomized clinical trials showed no advantages in favor of any treatment tested and, moreover, in 2 of such studies involving various single agents, survival was not better than a "no chemotherapy" control arm. Because of these data, we conclude that chemotherapy is not indicated as an adjuvant treatment for patients with localized prostate cancer. Although patients with prostate cancer frequently respond to androgen deprivation procedures, preclinical and clinical data strongly suggest the existence of endocrine-independent cell clones, which supports further testing with nonhormonal cytotoxic treatment. A close multidisciplinary interaction is a prerequisite for development of new effective systemic treatment in this disease.