gebhart/patrepeval huggingface dataset:
Why are circulating concentrations of endothelin-1 so low? (1994)

Physiological and pathophysiological roles of endothelins are still unclear. One reason is that circulating endothelin levels in normal and pathological states are much lower than the concentrations necessary to elicit contractions in vitro. It is usually assumed that endothelin accumulates in diseased tissues and that, because of its degradation, only a small fraction of it reaches the systemic circulation. Such a hypothesis does not fit with recent observations showing that low circulating endothelin levels may be active. We show here that most of the current inferences about the actions of endothelin assume that the peptide acts in the vessel wall under conditions known as non-stoichiometric binding conditions, that is, under conditions in which the receptor concentration in tissues ([Ro]) is smaller than the equilibrium dissociation constant of endothelin receptor complexes (Kd). Under stoichiometric binding conditions (defined by the condition [Ro] > Kd), most ligand molecules are bound to receptors and cannot be present in a free form. Estimates of [Ro] and Kd from the literature suggests that in vivo endothelin probably binds stoichiometrically to its receptors. Under this condition, most of tissue endothelin is probably bound to receptors. It is therefore suggested that plasma endothelin levels are low probably because tissue free endothelin levels are low, and this is not inconsistent with the presence of high tissue levels of active (that is, bound) endothelin. When the topology of the vessels with respect to the site of production (or of delivery) of endothelin is considered, stoichiometric binding may also account for the higher sensitivity to Et-1 of in vivo preparations. It also suggests that autocrine and paracrine actions of Et-1 are favoured at low and high secretory rates respectively, thus providing an explanation for the dual (vasodilator and vasoconstricting) actions of endothelin. Finally, the stoichiometric binding model predicts that functional receptors also act as clearance receptors and provides an explanation for the observation that antagonists of endothelin receptors are also clearance antagonists.
Finding Factors in Footfalls: Exploring the Factor Structure of Gait in Older Adults. (2021)

Abstract Gait is a reputed marker of global health spanning various bodily systems (MacDonald et al., 2017) and is a robust predictor of deleterious age-related outcomes (Van Kan et al., 2009). However, the sheer number of individual gait variables employed as predictors in the existing literature can obscure interpretations. To address this issue, researchers have explored the factor structure of gait indicators to explain variance in age-related gait performance, identifying disparate models characterized by three to five underlying latent gait constructs comprised of 8 to 23 indicators (Hollman et al., 2011; Lord et al., 2013). Beyond this heterogeneity, additional limitations characterizing this literature include solutions that assume statistical independence among gait constructs, as well as inclusion of severely multicollinear indicators. Using data from the Healthy Minds Healthy Bodies (HMHB) study, the present research focused upon replicating and contrasting previous factor analytic efforts. HMHB participants (n=128) were healthy community-dwelling adults (Mage=72.81±5.24 years; female=100). Gait indicators from a GAITRite computerized walkway were selected according to a priori theoretical rationale, compatibility with previous studies, and consideration of multicollinearity. Gait factor structure was initially analyzed using principal component analysis. Results indicate the presence of three latent gait domains reflecting pace, rhythm, and variability, accounting for over 82.4% of the variance in gait performance. Current proceedings involve implementing confirmatory factor analysis to compare competing gait models. Findings will address disparities across factor models in the gait literature, as well as discuss the optimal number of factors for describing the underlying dimensionality of gait.
Electronic Interplay between TTF and Extended-TCNQ Electrophores along a Ruthenium Bis(acetylide) Linker (2017)

A bis(TTF-butadiynyl) ruthenium D-D'-D complex, with intramolecular electronic interplay between the three electron-donating electrophores, was easily converted through a cycloaddition-retroelectrocyclization with TCNQ into a D-A-D'-A-D pentad complex, which exhibits an intense intramolecular charge transfer together with an electronic interplay between the two acceptors along the conjugated organometallic bridge.
The PIR domain of Grb14 is an intrinsically unstructured protein: implication in insulin signaling (2003)

Grb14 belongs to the Grb7 family of adapter proteins and was identified as a negative regulator of insulin signal transduction. Its inhibitory effect on the insulin receptor kinase activity is controlled by a newly discovered domain called PIR. To investigate the biochemical and biophysical characteristics of this new domain, we cloned and purified recombinant PIR-SH2, PIR, and SH2 domains. The isolated PIR and PIR-SH2 domains were physiologically active and inhibited insulin-induced reinitiation of meiosis in the Xenopus oocytes system. However, NMR experiments on (15)N-labelled PIR revealed that it did not present secondary structure. These results suggest that the PIR domain belongs to the growing family of intrinsically unstructured proteins.
Integrated transcriptomics and metabolomics decipher differences in the resistance of pedunculate oak to the herbivore Tortrix viridanaL. (2013)

We conclude that the resistant oak type seem to prefer a strategy of constitutive defence responses in contrast to more induced defence responses of the susceptible oaks triggered by feeding. These results pave the way for the development of biomarkers for an early determination of potentially green oak leaf roller-resistant genotypes in natural pedunculate oak populations in Europe.
Solution studies of cellulose in lithium chloride and N,N-dimethylacetamide (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolution studies of cellulose in lithium chloride and N,N-dimethylacetamideCharles L. McCormick, Peter A. Callais, and Brewer H. Hutchinson Jr.Cite this: Macromolecules 1985, 18, 12, 2394–2401Publication Date (Print):December 1, 1985Publication History Published online1 May 2002Published inissue 1 December 1985https://pubs.acs.org/doi/10.1021/ma00154a010https://doi.org/10.1021/ma00154a010research-articleACS PublicationsRequest reuse permissionsArticle Views4771Altmetric-Citations564LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
La Bibliografía General reciente sobre TT.OO. y anexos (1991)

LA BIBLIOGRAFA GENERAL ACTUAL SOBRE TT.OO.En un interesante trabajo publicado por Amo PENZIAS, Vicepresidente de Investigacin de la AT&T y Premio Nobel de Fsica en 1979, 25 podemos leer " Just a few years ago, most peopleincluding myselfthought of satelites as the ultirnate means of global communicatons... Today, however, 1 think iUs fair to say satelites
Vibrational energy relaxation in the condensed phases: Quantum vs classical bath for multiphonon processes (1997)

We develop a theory for relating quantum and classical time correlation functions in the context of vibrational energy relaxation. The treatment is based on the assumption that both the quantum and the classical systems are characterized by effective harmonic Hamiltonians with identical normal modes; and the solute-solvent interaction is taken to be linear in the solute vibrational coordinate, but nonlinear in the bath coordinates. We propose an approximate “quantum correction” which allows the determination of the quantum energy relaxation rates from the classical force-force time correlation functions in the limit of large solute’s vibrational frequency. We test the accuracy of this approximate correction against exact numerical results for two forms of the solute-solvent interaction (exponential and power law), and find it to be accurate for a wide range of solute vibrational frequencies and for different solvent thermodynamic states. A simple form of the “quantum correction” is proposed for the models based on Lennard-Jones interactions. In all cases it is found that the vibrational relaxation time in a fully quantum system is better approximated by a fully classical theory (classical oscillator in classical bath) than by a mixed quantum-classical theory (quantum oscillator in classical bath).
Anti-CRISPR Protein AcrIIC5 Inhibits CRISPR-Cas9 by Occupying the Target DNA Binding Pocket (2023)

Anti-CRISPR proteins inhibit CRISPR-Cas immune systems through diverse mechanisms. Previously, the anti-CRISPR protein AcrIIC5<sub>Smu</sub> was shown to potently inhibit a type II-C Cas9 from Neisseria meningitidis (Nme1Cas9). In this work, we explore the mechanism of activity of the AcrIIC5 homologue from Neisseria chenwenguii (AcrIIC5<sub>Nch</sub>) and show that it prevents Cas9 binding to target DNA. We show that AcrIIC5<sub>Nch</sub> targets the PAM-interacting domain (PID) of Nme1Cas9 for inhibition, agreeing with previous findings for AcrIIC5<sub>Smu</sub>, and newly establish that strong binding of the anti-CRISPR requires guide RNA be pre-loaded on Cas9. We determined the crystal structure of AcrIIC5<sub>Nch</sub> using X-ray crystallography and identified amino acid residues that are critical for its function. Using a protein docking algorithm we show that AcrIIC5<sub>Nch</sub> likely occupies the Cas9 DNA binding pocket, thereby inhibiting target DNA binding through a mechanism similar to that previously described for AcrIIA2 and AcrIIA4.
Statin—Fibrate Combination Therapy (2001)

Combination therapy with a statin and fibrate offers significant therapeutic advantage for the treatment of severe or refractory mixed hyperlipidemia. Although such a combination does increase the risk of myopathy, with an incidence of approximately 0.12%, this small risk of myopathy rarely outweighs the established morbidity and mortality benefits of achieving lipid goals. Nevertheless, a higher incidence of myopathy has been reported with statin monotherapy. When monotherapy with a statin fails to control mixed hyperlipidemia, combination therapy may be considered. Niacin may be added before a fibrate is considered, as it appears to have less risk of myopathy. Statin-fibrate combination therapy must be undertaken cautiously and only after careful risk-benefit analysis. Patient counseling on the risks and warning signs of myopathy is extremely important.
General lecturing principles (2007)

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Moderate Intensity Exercise Ameliorates Negative Impacts of Simulated Altitude on Executive Function. (2017)

PURPOSE: The present study was conducted to examine the behavioral cognitive and neurophysiological effects of acute exposure to simulated moderate and high altitudes at rest and during exercise in an effort to delineate whether there is a level of simulated altitude beyond which executive cognitive functions are impaired and whether exercise improves or worsens cognitive function during exposure to simulated altitude. METHODS: Fourteen recreationally active college students (M=9, F=5) aged 18-35 participated in this study, which consisted of six experimental days, with three simulated altitude conditions: sea level (SL), simulated moderate altitude (MA; 15.4% FIO2, ~2400 m) or simulated high altitude (HA; 12.8% FIO2, ~3900 m); and two exercise conditions: rest or moderate intensity cycling exercise at 60% altitude-specific peak power output, in a randomized-order, crossover design. Dependent variables included accuracy and reaction time on two executive cognitive function tasks (a modified Flanker task and a Stroop task), and the amplitude and latency of their associated event-related potentials. RESULTS: For the Flanker task, both MA and HA slowed down reaction time (p=0.04), while exercise improved reaction time (p=0.01). Similarly, for the Stroop task, HA (though not MA) slowed reaction time (p=0.02), while exercise improved reaction time (p=0.04). Accuracy was preserved under all conditions. These effects were partially explained by alterations in associated event-related potential amplitudes and latencies, such as slower N200 latencies with altitude (p=0.04) but faster latencies with exercise (p<0.01), as well as reduced P300 amplitude and slower latency with altitude (p<0.01), and reduced amplitude but faster latency with exercise (p=0.03). CONCLUSIONS: Acute exposure to simulated altitudes slows behavioral cognitive reaction time on executive function tasks while preserving task accuracy. An acute bout of moderate intensity cycling exercise improves reaction times so that they are comparable to those achieved without exercise or simulated altitude exposure, at least in instances where exercise does not exacerbate the peripheral oxygen saturation drops seen with simulated altitude.
Small Wind Energy Systems (2015)

The application of small wind turbines for residential and commercial applications depends on how a microgrid can operate in a suitable way. Because there is variable demand and a random nature of wind resources, it is usually necessary the installation of controllable end-use loads, storage devices, and a centralized distribution control. In order to establish a small wind energy system it is important to observe the following: (i) Attending the energy requirements of the actual or future consumers; (ii) Establishing civil liabilities in case of accidents and financial losses due to shortage or low quality of energy; (iii) Negotiating collective conditions to interconnect the microgrid with the public network or with other sources of energy that is independent of wind resources; (iv) Establishing a performance criteria of power quality and reliability to end-users, in order to reduce costs and guaranteeing an acceptable energy supply. This paper discuss how performance is affected by local conditions and random nature of the wind, power demand profiles, turbine related factors, and presents the technical issues for implementing a self-excited induction generator system, or a permanent magnet based wind turbine control, in addition of discussing the use of Magnus effect wind turbines for small scale generation.
Standardization of clinical investigators for studies of restorative materials. (1981)

In preparation for internordic studies of the clinical performance of selected restorative materials, 11 clinicians from Denmark, Finland, Norway and Sweden were selected to participate in two clinical training sessions. The first of these sessions consisted of lectures on clinical research methodology, the content of a research protocol and specific description of the criteria to be used for clinical evaluation of Color Match, Cavo Surface Margin Discoloration, Anatomic Form, Margin Adaptation, and Caries. Demonstrations were also given in the clinical evaluation procedures. Using a rotation system at both the training sessions each participant alternatively served as patient recorder and examiner. The participants examined and rated a larger number of restorations independently in teams of two. The results of the performed examinations showed the overall agreement between all pairs to exceed 85%. The results of this study indicate that after a short introductory course, scientifically non-experienced senior clinicians can be trained to use the described system at a comparatively high overall level of precision.
Influence of Stabilizers on the Production of disulfiram-loaded poly(lactic-co-glycolic acid) Nanoparticles and Their Anticancer Potential (2015)

Physiochemical characterization and the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay suggest that polysorbate 80 has the dual capability of being a stabilizer and a surface modifier in addition to having better drug entrapment properties than Pluronic® 188. Disulfiram, the drug that was loaded on these NPs, is also observed for the first time to show significant anticancer potential against hepatocellular carcinoma (Hep3B) cell lines.
Speech enhancement using resonator filterbanks (1991)

A speech enhancement algorithm for wideband noise reduction based on an analysis-synthesis resonator filter bank (ASRF) configuration is proposed. This choice is motivated by the observation that the configuration demonstrates excellent synthesis properties when time-varying spectral amplitude modifications are allowed at the output of the analysis stage and because the resonator filter banks are computationally efficient when implemented on single-chip digital signal processors. The noise reduction technique is in the family of algorithms which perform spectral decomposition of the noisy signal to estimate the short-time spectral amplitude of the speech signal. The ASRF speech enhancement algorithm was tested on speech degraded by different kinds of broadband noise and the enhanced speech was compared with material produced by other speech enhancement algorithms.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Practical Power Allocation for Cooperative Distributed Antenna Systems (2010)

In this letter, we address the problem of downlink power allocation for the generalized distributed antenna system (DAS) with cooperative clusters. Considering practical applications, we assume that only the large-scale channel state information is available at the transmitter. The power allocation scheme is investigated with the target of ergodic achievable sum rate maximization. Based on some approximations and the Rayleigh Quotient Theory, the simple selective power allocation scheme is derived for the low SNR scenario and the high SNR scenario, respectively. The methods are applicable in practice due to their low complexity.
Managing the Quality Effort in a Health Care Setting: An Application (1999)

Recent marketplace realities and trends have forced health care institutions to adopt strategic orientations that stress a customer focus. Central to such strategic orientations is the effective utilization of service quality practices and philosophies. Toward that end, this research offers health care institutions an affordable methodology. A real-life application of the rapid assessment methodology (RAM) in a health care operational setting is presented. Finally, a framework to guide the implementation of the RAM methodology is outlined and explored.
Atom‐Transfer Radical Reactions under Mild Conditions with [{RuCl2(1,3,5‐C6H3iPr3)}2] and PCy3 as the Catalyst Precursors (2005)

Einfaches Mischen des Komplexes [{RuCl2(1,3,5-C6H3iPr3)}2] (1) mit PCy3 liefert einen Katalysator, der bei außergewöhnlich niedrigen Temperaturen Atomtransfer-Radikalpolymerisationen und -additionen hoch effizient katalysiert (siehe Schema). Die sterische Überladung am Metall als Folge der sperrigen Liganden wird als entscheidend für die Reaktivität des Katalysators gesehen. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2005/z462037_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
AN EMBEDDED SW DESIGN EXPLORATION APPROACH BASED ON UML ESTIMATION TOOLS (2005)

Software engineers, when modeling an application using object-oriented concepts and the UML language, do not have an idea of the impact of their modeling decisions on issues such as performance, energy, and memory footprint for a given embedded platform. However, these are critical characteristics for embedded systems and should be taken into account in early design stages. In our approach, estimation of data and program memory, performance and energy are obtained from an initial UML specification. It allows the designer to evaluate and compare different modeling solutions, thus supporting design space exploration at a very high abstraction level. A case study is used to demonstrate our approach, in which an application is modeled in different ways and the alternative solutions are compared using the high-level estimations. Experimental results are presented and demonstrate the effectiveness of the estimates in an early design space exploration.
Promoter Motifs in NCLDVs: An Evolutionary Perspective (2017)

For many years, gene expression in the three cellular domains has been studied in an attempt to discover sequences associated with the regulation of the transcription process. Some specific transcriptional features were described in viruses, although few studies have been devoted to understanding the evolutionary aspects related to the spread of promoter motifs through related viral families. The discovery of giant viruses and the proposition of the new viral order Megavirales that comprise a monophyletic group, named nucleo-cytoplasmic large DNA viruses (NCLDV), raised new questions in the field. Some putative promoter sequences have already been described for some NCLDV members, bringing new insights into the evolutionary history of these complex microorganisms. In this review, we summarize the main aspects of the transcription regulation process in the three domains of life, followed by a systematic description of what is currently known about promoter regions in several NCLDVs. We also discuss how the analysis of the promoter sequences could bring new ideas about the giant viruses' evolution. Finally, considering a possible common ancestor for the NCLDV group, we discussed possible promoters' evolutionary scenarios and propose the term "MEGA-box" to designate an ancestor promoter motif ('TATATAAAATTGA') that could be evolved gradually by nucleotides' gain and loss and point mutations.
Is Vagal Response During Left Atrial Ganglionated Plexi Stimulation a Normal Phenomenon? (2019)

Overall, more active-GP areas were found in the AF group patients than in the non-AF group patients, and at all 5 major GPs, the maximum R-R interval during HFS was significantly prolonged in the AF patients. After multivariate adjustment, association was established between the total number of vagal response sites and the presence of AF. Conclusions The significant increase in vagal responses elicited in patients with AF compared with responses in non-AF patients suggests that vagal responses to HFS reflect abnormally increased GP activity specific to AF substrates.
Supplementary document for CryoSIM: super resolution 3D structured illumination cryogenic fluorescence microscopy for correlated ultra-structural imaging - 4631682.pdf (2020)

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