gebhart/patrepeval huggingface dataset:
The time is right for Web-based clinical simulation in nursing education (2015)

E-simulation involves goal-based role play using digital simulations that take place via a computer screen. Learners interact with the program via multi-media applications such as animation and video, graphics, sound, vision, and text through the use of advanced Web authoring tools. When the simulation is Web-based (via a remote server), this allows data collection and real-time feedback. We aimed to explore how the Internet has been utilized for the purposes of e-simulation in healthcare education. We describe published resources focusing on pre-registration education for undergraduate nursing and medicine students. Many studies in these domains have developed e-simulation as components of research, but we identified only four that were openly accessible (without fees). We describe four Web-based simulation programs that will benefit learners through better understanding of cardiopulmonary resuscitation; patient deterioration recognition and management; communication with the mentally ill; and knowledge of cultural competence. These programs have the advantage of being available across borders and are accessible to a broad audience wherever there is adequate Internet access. The approach appears to be highly acceptable to learners and offers the opportunity for repeated practice. The time is right for greater distribution and sharing of Web-based simulation resources for teaching in both undergraduate and at professional levels. Web-based simulation programs are a valuable resource that can be used in combination with traditional forms of laboratory and classroom teaching, in order to facilitate the development of students’ clinical competence.
Effects of Antifungal Interventions on the Outcome of Experimental Infections with Phenotypic Switch Variants ofCryptococcus neoformans (2004)

In cryptococcal infection, phenotypic switching from a smooth to a mucoid variant can occur in vivo, producing variants with enhanced virulence that are subsequently selected and affect the outcome of infection. Here, we demonstrate that antifungal treatment of the chronically infected host can promote this phenomenon. Amphotericin B treatment reduces fungal burden less effectively in mucoid variant-infected than in smooth variant-infected mice. Consequently, amphotericin B treatment resulted in a more pronounced prolongation of survival in smooth variant-infected than in mucoid variant-infected mice (20 versus 42 days; P < 0.05). Administration of anticapsular monoclonal antibody mediated better protection in smooth variant-infected than in mucoid variant-infected mice, although a protective effect was not consistently observed at all doses. Most interestingly, both antifungal drug therapy and administration of anticapsular monoclonal antibody promoted the selection of mucoid variants in smooth variant-infected mice, a phenomenon manifested by a statistically higher percentage of mucoid colonies in smooth variant-infected mice than in nontreated control mice. This finding suggests that both chemotherapeutic and immunological antifungal interventions may promote the selection of the more virulent mucoid variant, which could affect the outcome of infection in chronically infected hosts.
A physiological method for relaying frictional information to a human teleoperator (1993)

The ability to sense and respond to frictional variations is important for dexterous manipulation. It is demonstrated that it is possible to elicit rapid, nonhabituating and sustained grasp responses by means of a tactile display. Experiments in which subjects grasped and lifted an instrumented test object using the thumb and index finger are reported. While the object was held in air, rapid but small sliding movements were invoked between the object and either contact plate and caused a load force redistribution. This reliably triggered a grasp force increase similar to the ones elicited by natural slips occurring during normal manipulation. An important application of this finding is in relaying frictional information from a slave hand to a human operator. Furthermore, it may make it possible to reduce disparity between master and slave hands in force reflective telemanipulation systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Protective effects of isohelenin, an inhibitor of nuclear factor κB, in endotoxic shock in rats (2002)

Recent in vitro studies have shown that isohelenin, a sesquiterpene lactone, inhibits the NF-κB pathway. This study examines the effect of isoheleninin endotoxic shock induced by administration of Escherichia coli endotoxini n male Wistar rats. A group of rats received isohelenin (2 mg/kg intraperitoneally)15 min before endotoxin. In vehicle-treated rats, administration of endotoxin caused severe hypotension, which was associated with a marked hyporeactivity to norepinephrine and acetylcholine in ex vivo aortas. Elevated levels of plasma nitrate/nitrite, metabolites of nitric oxide (NO), were also found. These inflammatory events were preceded by cytosolic degradation of inhibitor-κBα (IκBα) and activation of nuclear factor-κB (NF-κB) in the lung within 15 min of endotoxin administration. Treatment with isohelenin resulted in hemodynamicimprovement and reduced plasma levels of NO metabolites. Nuclear translocation of NF-κB was inhibited by isohelenin treatment in the lung, whereas degradation of IκBα was unchanged. In a separate set of experiments, treatment with isohelenin significantly improved survival in mice challenged with endotoxin. We conclude that isohelenin exerts beneficial therapeutic effects during endotoxic shock through inhibition of NF-κB.
Complete wavelength control of GCSR lasers over EDFA band (2003)

A characterisation procedure is described to locate stable operating points of a GCSR laser. The characterisation algorithm reduces the characterisation time of a GCSR laser from days to 30 minutes. Any wavelength in the tuning range of the laser is available. The laser can then be used to meet any wavelength/frequency plan e.g. ITU G692. This algorithm was applied to a GCSR laser and 38 nm tuning was obtained from 1566.57 nm to 1528.66 nm (191.5 THz to 196.25 THz). The accuracy was better than /spl plusmn/ 3GHz.
Shock Initiation of Detonation in Liquid Explosives (1961)

Experimental studies of the initiation of liquid explosives by strong plane shocks (pressures 50 to 100 kbar) are described. These experiments demonstrate thermal explosion as a result of shock heating in the explosive. When the shock enters the explosive, the explosive is heated. After a delay, detonation in the heated, compressed explosive begins at the interface, where the explosive has been hot longest. The detonation proceeds through the compressed explosive at a velocity greater than the steady state velocity in uncompressed explosive, overtaking the initial shock and overdriving detonation in the unshocked explosive. Most of the work has been done on nitromethane, but molten TNT, molten DINA, Dithekite 13, and single crystals of PETN are shown to behave in the same way. Experiments showing the effects of bubbles and shock interactions in the explosive are presented.
Absorption and lipoprotein transport of sphingomyelin (2005)

Dietary sphingomyelin (SM) is hydrolyzed by intestinal alkaline sphingomyelinase and neutral ceramidase to sphingosine, which is absorbed and converted to palmitic acid and acylated into chylomicron triglycerides (TGs). SM digestion is slow and is affected by luminal factors such as bile salt, cholesterol, and other lipids. In the gut, SM and its metabolites may influence TG hydrolysis, cholesterol absorption, lipoprotein formation, and mucosal growth. SM accounts for ∼20% of the phospholipids in human plasma lipoproteins, of which two-thirds are in LDL and VLDL. It is secreted in chylomicrons and VLDL and transferred into HDL via the ABCA1 transporter. Plasma SM increases after periods of large lipid loads, during suckling, and in type II hypercholesterolemia, cholesterol-fed animals, and apolipoprotein E-deficient mice. SM is thus an important amphiphilic component when plasma lipoprotein pools expand in response to large lipid loads or metabolic abnormalities. It inhibits lipoprotein lipase and LCAT as well as the interaction of lipoproteins with receptors and counteracts LDL oxidation. The turnover of plasma SM is greater than can be accounted for by the turnover of LDL and HDL particles. Some SM must be degraded via receptor-mediated catabolism of chylomicron and VLDL remnants and by scavenger receptor class B type I receptor-mediated transfer into cells.
Robustness of Indoor Aquatic Mesocosm Experimentations and Data Reusability to Assess the Environmental Risks of Nanomaterials (2021)

Indoor aquatic mesocosms are increasingly used in nanosafety to assess the behavior, fate, and impacts of engineered nanomaterials (ENMs) in aquatic environments using relevant exposure scenarios. The robustness of 60 L freshwater mesocosm experimentation was tested on the basis of the reusability of the data collected in a database named MESOCOSM regarding mesocosm experiments examining the environmental risks of CeO 2 ENMs. We observed high reliability of the measured variables across replicates. The sensitivity of this mesocosm methodology was evidenced by the contrasted ecosystem responses revealed by a multivariate analysis. We also observed that adding variables to the data set up to 15% did not affect the outcome of the analysis of the results. This ability to buffer this variability demonstrates that the indoor aquatic mesocosms are robust tools contributing to the environmental risk assessment of ENMs, and stresses the benefit of reusing the data stored in databases such as MESOCOSM adhering to the findable, accessible, interoperable, reusable (FAIR) data principles.
The Duquesne Opinion: How Much "Hope" is There f6r Investors in Regulated Firms? (1991)

In Duquesne Light Co. v. Barasch, the Supreme Court ruled that regulatory risks generally require compensation to utility investors, although "slight" losses from changes in the regulatory rules faced by investors are constitutional. However, it will be difficult or impossible to provide the compensation envisioned by the Court if regulators adopt rules of the sort in effect in the 1980s. In particular, traditional procedures for setting allowed rates of return for investors in regulated companies can fall substantially short of the required compensation. As a result, either regulatory institutions will have to change materially from those of the 1980s or material disincentives to new utility investment will persist indefinitely.
Dissociation of the glycaemic and insulinaemic responses to whole and skimmed milk (2005)

In most carbohydrate-containing foods, the blood insulin response is predictable and is closely linked to the food's glycaemic index (GI). A single study, examining whole milk and fermented milk products made from whole milk, recently reported a large dissociation between the GI and insulinaemic index (II) in healthy normal adults. Because the fat component of a food may influence the GI and II, it is unclear if a similar dissociation may exist for skimmed milk in normal adults. We determined the GI and II of both skimmed and whole milk in nine healthy, male (n 6) and female (n 3) subjects (23.6 (sd 1.4) years). No significant (P>0.05) differences existed between GI and II for skimmed and whole milks. Significant (P<0.05) differences were observed between the actual and predicted areas under the insulin curves for both skimmed milk (predicted 1405 (sd 289) pmol x min/l; actual 6152 (sd 1177) pmol x min/l) and whole milk (predicted 1564 (sd 339) pmol x min/l; actual 5939 (sd 1095) pmol x min/l). Consequently, a large and similar dissociation of the GI and II existed for both whole milk (42 (sd 5) and 148 (sd 14)) and skimmed milk (37 (sd 9) and 140 (sd 13)). It is concluded that the dissociation of the GI and II in milk is not related to its fat content.
Serum proteome profiling for diagnostics of ovarian cancer using ClinProt magnetic technique and MALDI-TOF mass spectrometry (2008)

Using ClinProt magnetic beads with reverse-phase (MB-HIC 8 and HB-HIC 18), weak cation exchange (MB-WCX) and metal affinity (MB-IMAC Cu) surfaces fractions of peptides and proteins were isolated from human sera for their profiling by MALDI-TOF mass spectrometry. Proteome profiling of sera from basically healthy women (47 subjects, average age 49) and from women with verified ovarian cancer (stages 1-IV, 47 patients, average age 51) by means of MB-WCX beads allowed to generate the best diagnostic models based on Genetic Algorithm and Supervised Neural Network classifiers; these models demonstrated 100% sensitivity and specificity during analysis of the test set. Introduction of additional sera from patients with colorectal cancer (19) and ulcerous colitis (5) to the statistical model confirmed 100% ovarian cancer recognition. Statistical analysis of mass-spectrometry peak areas included to the diagnostic classifiers showed 3 peaks characteristic for ovarian cancer and 4 peak areas exhibiting changes associated with both ovarian and colorectal cancer.
Laserstrahlbeschichten von NiCrBSi-Hartlegierungen durch einen Pulverförderprozeß (1991)

Article Laserstrahlbeschichten von NiCrBSi-Hartlegierungen durch einen Pulverförderprozeß was published on March 1, 1991 in the journal HTM Journal of Heat Treatment and Materials (volume 46, issue 2).
Technical Aspects of Cementless Total Hip Arthroplasty (1990)

The technique of cementless total hip arthroplasty (THA) places many demands on the surgeon, who must understand the rationale of the prosthetic design to take full advantage of its features. In addition, the surgeon must be able to gauge the quality of the available bone either by preoperative roentgenographic examination or by intraoperative assessment or both. The surgeon must then choose the prosthesis that will predictably fit the individual conditions. Proper instrumentation, practice in a workshop environment, prophylactic wiring of the femur, and postimplantation testing of the prosthesis are important to achieve lasting results of cementless THA.
Treatment of Pentachlorophenol with Manganese Oxide Addition to Biotic and Abiotic Sediments (1995)

Laboratory microcosms containing subsamples of a complex environmental sediment were used to evaluate the addition of oxidized manganese as the primary electron acceptor in the presence of pentachlorophenol (PCP) as the primary electron donor. Manganese oxide (MnO2) particles were added to poisoned abiotic and non-poisoned biotic microcosms and incubated at 11°C in the presence of sediment samples that were shown capable of mineralizing PCP with indigenous microorganisms. Reduction in PCP concentration and production of reduced manganese was measured for both abiotic and biotic systems. PCP was observed to be transformed most rapidly and to the greatest extent in non-poisoned microcosms. Rate and extent of PCP transformation were increased when MnO2 was added. Rate and extent of PCP transformation were least, but still significant, in abiotic (poisoned) microcosms when MnO2 was added. Reduction in PCP sediment concentration was consistently correlated with an increase in production of reduced manganese (Mn+2). The addition of MnO2 was therefore shown to cause a decrease in PCP concentration in a naturally occurring complex environmental sediment. Reduced iron was observed suggesting that both manganese and iron were used as primary electron acceptors. Moreover, higher concentrations of Mn+2 were found in solution than +2Fe. This may support thermodynamic evidence that manganese is preferentially used over iron in some redox reactions. Addition of synthetic MnO2 particles via a permeable reaction wall or direct slurry injection, may represent a potential treatment approach for the abiotic as well as biotic reduction of PCP in sediment and ground water environments.
Competitive binding to the oligopeptide binding protein, OppA: In-trap cleanup in an fourier transform ion cyclotron resonance mass spectrometer (2000)

This communication demonstrates that gentle infrared laser heating can remove unwanted buffer adducts from a gas-phase protein complex without dissociating the complex itself. Specifically, noncovalent complexes of the oligopeptide-binding protein, OppA, bound to either (Ala)3 or LysTrpLys were electrosprayed from aqueous buffer solution into a 9.4 tesla Fourier transform ion cyclotron resonance mass spectrometer. In addition to the intact complexes, several additional buffer adduct species were produced under the conditions of the experiment. Irradiation of the trapped ion population with a continuous-wave infrared CO2 laser at relatively low power (2.5 W) for 1 s dissociated the buffer adducts but retained the intact protein:peptide complexes. Adduct-free complex(es) were then readily identified, and signal-to-noise ratio also increased by an order of magnitude because the same number of protein ions are distributed over fewer species. Higher IR power (5 W for 1 s) dissociated the adduct-free complex(es) without internal fragmentation. The present in-trap clean-up technique may prove especially useful for identifying and screening the combinatorial library ligands most strongly bound to a receptor in the gas phase.
The Quartercentenary Lecture (1993)

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Return to sports bridge program improves outcomes, decreases ipsilateral knee re-injury and contralateral knee injury rates post-ACL reconstruction (2020)

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DNA Compaction onto Hydrophobic Surfaces by Different Cationic Surfactants (2005)

DNA compaction by alkyltrimethylammonium surfactants at hydrophobized silica surfaces and the effect of the counterion, as well as the hydrocarbon chain length, was investigated by in situ null-ellipsometry. In addition, DNA compaction in the presence of a gemini surfactant, hexyl-alpha,omega-bis(dodecyldimethylammonium bromide), was studied. The type of cationic amphiphile used was found not to have a pronounced effect on the mixed DNA-cationic surfactant adsorbed layer thickness, although the surface concentration excess for the mixed layers seemed to follow the same trend as that for DNA-free surfactant layers. Interestingly, it was also found that the stability of the mixed adsorbed layer largely depends on the cationic surfactant used.
High Performance Fabry-Perot Modulator Using Interdiffused AlGaAs/GaAs Quantum Wells (1996)

Interdiffused AlGaAs/GaAs quantum well structures are being employed as an active cavity material in the Fabry-Perot reflection type modulators. An extremely large relative reflectance change (over 14000) is predicted, higher than any value that has been reported among the available literature today. This is due to an extremely low reflectance (∼10 -5 ) at the resonance of the Fabry-Perot mode while simultaneously the change of reflectance is kept around the order of unity. The power consumption is reduced by 67% due to the highly sensitive electrons in the interdiffused wells. A wide operation wavelength range of over 100 nm is also observed.
Hyperbranched aliphatic polyethers obtained from environmentally benign monomer: glycerol carbonate (2005)

A hyperbranched aliphatic polyether with hydroxyl end groups was produced from glycerol carbonate (4-hydroxymethyl-1,3-dioxolan-2-one)—the benign monomer obtained from renewable starting materials: glycerol and dimethyl carbonate. Anionic polymerization of glycerol carbonate, which proceeds with simultaneous decarboxylation, was performed using partially deprotonated trimethylolpropane (TMP) as an initiator. Pendant hydroxyl groups facilitate the ring-opening multibranching polymerization leading to a hyperbranched polyether. 13C NMR analysis of the polymerization products confirmed the presence of linear, dendritic, and terminal repeating units. MALDI-TOF mass spectrum analysis confirmed the presence of TMP and glycerol core containing branched structures as well as a relatively small amount of macromolecules with cyclic groups. The polymers were soluble in water, THF, methanol and DMSO.
The Effect of Kinesio Taping on Lower Trunk Range of Motions (2007)

The purpose of the study was to determine the effects of kinesio taping (KT) on trunk flexion, extension, and lateral flexion. Thirty healthy subjects with no history of lower trunk or back issues participated in the study. Subjects performed two experimental measurements of range of motion (with and without the application of KT) in trunk flexion, extension, and right lateral flexion. A dependent t test was used to compare the range of motion measurements before and after the application of KT. Through evaluation of the sum of all scores, KT in flexion produced a gain of 17.8 cm compared with the non-kinesiotape group (t(29)=2.51, p<0.05). No significant difference was identified for extension (-2.9 cm; t(29)=-0.55, p>0.05) or lateral flexion (3 cm; t(29)=-1.25, p>0.05). Based on the findings, we determined that KT applied over the lower trunk may increase active lower trunk flexion range of motion. Further investigation on the effects of KT is warranted.
A New Metric for Permutation Polynomial Interleavers (2006)

The spread factor of an interleaver is a common measure for turbo coding applications. Maximum-spread interleavers are interleavers whose spread factors achieve the upper bound. An infinite sequence of quadratic permutation polynomials over integer rings that generate maximum-spread interleavers is presented. New properties of permutation polynomial interleavers are investigated from an algebraic-geometric perspective resulting in a new non-linearity metric for interleavers. A new interleaver metric that is a function of both the non-linearity metric and the spread factor is proposed. A table of good interleavers for a variety of interleaver lengths according to the new metric is listed. Extensive computer simulation results with impressive frame error rates confirm the efficacy of the new metric. Further, when tail-biting constituent codes are used, the resulting turbo codes are quasi-cyclic
Mismatch repair proteins recruit DNA methyltransferase 1 to sites of oxidative DNA damage (2015)

At sites of chronic inflammation, epithelial cells are exposed to high levels of reactive oxygen species and undergo cancer-associated DNA methylation changes, suggesting that inflammation may initiate epigenetic alterations. Previously, we demonstrated that oxidative damage causes epigenetic silencing proteins to become part of a large complex that is localized to GC-rich regions of the genome, including promoter CpG islands that are epigenetically silenced in cancer. However, whether these proteins were recruited directly to damaged DNA or during the DNA repair process was unknown. Here we demonstrate that the mismatch repair protein heterodimer MSH2-MSH6 participates in the oxidative damage-induced recruitment of DNA methyltransferase 1 (DNMT1) to chromatin. Hydrogen peroxide treatment induces the interaction of MSH2-MSH6 with DNMT1, suggesting that the recruitment is through a protein-protein interaction. Importantly, the reduction in transcription for genes with CpG island-containing promoters caused by oxidative damage is abrogated by knockdown of MSH6 and/or DNMT1. Our findings provide evidence that the role of DNMT1 at sites of oxidative damage is to reduce transcription, potentially preventing transcription from interfering with the repair process. This study uniquely brings together several factors that are known to contribute to colon cancer, namely inflammation, mismatch repair proteins, and epigenetic changes.
The evaluation of ``Kondo'' and other integrals of arbitrary range (1974)

It is pointed out that integrals over arbitrary ranges and indefinite integrals may often be obtained very simply by the methods of contour integration.