gebhart/patrepeval huggingface dataset:
EFFICACY OF PROCALCITONIN IN THE EARLY DIAGNOSIS OF BACTERIAL INFECTIONS IN A CRITICAL CARE UNIT (2008)

SHOCK®: Injury, Inflammation, and Sepsis: Laboratory and Clinical Approaches includes studies of novel therapeutic approaches, such as immunomodulation, gene therapy, nutrition, and others. The mission of the Journal is to foster and promote multidisciplinary studies, both experimental and clinical in nature, that critically examine the etiology, mechanisms and novel therapeutics of shock-related pathophysiological conditions. Its purpose is to excel as a vehicle for timely publication in the areas of basic and clinical studies of shock, trauma, sepsis, inflammation, ischemia, and related pathobiological states, with particular emphasis on the biologic mechanisms that determine the response to such injury. Making such information available will ultimately facilitate improved care of the traumatized or septic individual. SHOCK® is also privileged to have fourteen distinguished Associate Editors, as well as a diverse group of editorial board members from various parts of the world, who enjoy the respect and admiration of their colleagues in their areas of investigation. The Official Journal of the Shock Society, the European Shock Society, the Indonesian Shock Society, the International Federation of Shock Societies, and the Official and International Journal of the Japan Shock Society
Millimeter Wave Horn Antenna with Tilted Beam (2022)

A broadband directional equal-beamwidth millimeter-wave(mmW) horn antenna is proposed in this paper. A shovel-shaped structure is used for the aperture surface of the traditional rectangular horn antenna, which can tilt the beam toward the opening of the shovel-shaped structure. To verify the idea, a horn antenna with a down-tilted beam was designed, fabricated, and measured. The measured results are in good agreement with the simulated ones. A measured 49.9% 15-dB impedance bandwidth can be obtained, from 25.4 to 42.3 GHz, which can fully cover the Ka band of 26.5-40 GHz, and its downtilt angle of the main beam is 13° at 31.5 GHz.
Nanoparticle-enhanced synergistic HIFU ablation and transarterial chemoembolization for efficient cancer therapy (2016)

High-intensity focused ultrasound (HIFU) is being generally explored as a non-invasive therapeutic modality to treat solid tumors. However, the clinical use of HIFU for large and deep tumor-ablation applications such as hepatocellular carcinoma (HCC) is currently entangled with long treatment duration and high operating energy. This critical issue can be potentially resolved by the introduction of HIFU synergistic agents (SAs). Traditional SAs such as microbubbles and microparticles face the problem of large size, short cycle time, damage to mononuclear phagocytic system and unsatisfactory targeting efficiency. In this work, we have developed a facile and versatile nanoparticle-based HIFU synergistic cancer surgery enhanced by transarterial chemoembolization for high-efficiency HCC treatment based on elaborately designed Fe3O4-PFH/PLGA nanocapsules. Multifunctional Fe3O4-PFH/PLGA nanocapsules were administrated into tumor tissues via transarterial injection combined with Lipiodol to achieve high tumor accumulation because transarterial chemoembolization by Lipiodol could block the blood vessels. The high synergistic HIFU ablation effect was successfully achieved against HCC tumors based on the phase-transformation performance of the perfluorohexane (PFH) inner core in the composite nanocapsules, as systematically demonstrated in VX2 liver tumor xenograft in rabbits. Multifunctional Fe3O4-PFH/PLGA nanocapsules were also demonstrated as efficient contrast agents for ultrasound, magnetic resonance and photoacoustic tri-modality imagings, potentially applicable for imaging-guided HIFU synergistic surgery. Therefore, the elaborate integration of traditional transarterial chemoembolization with recently developed nanoparticle-enhanced HIFU cancer surgery could efficiently enhance the HCC cancer treatment outcome, initiating a new and efficient therapeutic protocol/modality for clinic cancer treatment.
Spinal muscular atrophy genewobbler of the mouse: Evidence from chimeric spinal cord and testis for cell-autonomous function (1997)

Human hereditary neurodegenerative diseases are genetically and mechanistically very heterogeneous and so are spinal muscular atrophies and cerebellar ataxias in the mouse, despite the common phenomenon of neuronal death. In this species, a number of mutations impair spermiogenesis in addition to neuron survival. Among these, the wobbler mutation on proximal chromosome 11 of the mouse leads to motoneuron degeneration in brain stem and spinal cord and to a defect of spermiogenesis. Chimeric mice of the type wr?/wr? <--> +/+ were produced, and their allelic status at the wr locus was determined by PCR diagnosis of a closely linked marker. Two overt chimeras, one female (XX <--> XX) and one male (XY <--> XY) were identified as wr/wr <--> +/+ and analyzed with respect to their pathological phenotype. Although there was patchy astrogliosis in the spinal cords of both chimeras, their motor performances were overtly normal and muscles were without signs of denervation. The male's testes revealed a mosaic pattern of normal and pathological spermatids. As no progeny was derived from wr spermatids, the spermatocytes appear as a primary target of the wr mutation in testis. Our results argue against a humoral mechanism of the wobbler disease and indicate a cell-autonomous action of the wr gene both in testis and in spinal cord.
Notice of Removal: A few twists regarding the momentum of shaped beams (2017)

Removed.
Annual Default Rates are Probably Less Than Long-Run Average Annual Default Rates (2008)

Banks using either the Foundation or Advanced option of the internal ratings based approach to credit risk under Basel II capital requirements must estimate long-run annual average default probabilities for buckets of homogeneous assets. The one-factor model underlying the capital calculations in Basel II has implications for the distribution of average (across assets) default rates over time. One of these implications is that the average default rate in any period is probably smaller than the overall average default rate (over time and assets). The lesson for practitioners is that the short-term default experience of new, very safe assets is likely to underpredict the true long-run default rate for these assets. <b>TOPICS:</b>Factor-based models, legal/regulatory/public policy, information providers/credit ratings
Method of fabricating rigid radiation reflectors (2023)

A rigid radiation reflector is fabricated from a powdered material transparent to light in a wavelength band extending from approximately 0.2 micrometers to at least 8 micrometers. The powdered material is dispersed in a liquid wherein the powdered material is at least 95% insoluble in the liquid. The resulting mixture is molded under pressure at room temperature and then sintered to generate a porous solid. The porous solid is cooled to room temperature. A surface of the porous solid is then coated with a light-reflecting metal.
Phase-stable, multi-µJ femtosecond pulses from a repetition-rate tunable Ti:Sa-oscillator-seeded Yb-fiber amplifier (2016)

We present a high-power, MHz-repetition-rate, phase-stable femtosecond laser system based on a phase-stabilized Ti:Sa oscillator and a multi-stage Yb-fiber chirped-pulse power amplifier. A 10-nm band around 1030 nm is split from the 7-fs oscillator output and serves as the seed for subsequent amplification by 54 dB to 80 W of average power. The µJ-level output is spectrally broadened in a solid-core fiber and compressed to ~30 fs with chirped mirrors. A pulse picker prior to power amplification allows for decreasing the repetition rate from 74 MHz by a factor of up to 4 without affecting the pulse parameters. To compensate for phase jitter added by the amplifier to the feed-forward phase-stabilized seeding pulses, a self-referencing feed-back loop is implemented at the system output. An integrated out-of-loop phase noise of less than 100 mrad was measured in the band from 0.4 Hz to 400 kHz, which to the best of our knowledge corresponds to the highest phase stability ever demonstrated for high-power, multi-MHz-repetition-rate ultrafast lasers. This system will enable experiments in attosecond physics at unprecedented repetition rates, it offers ideal prerequisites for the generation and field-resolved electro-optical sampling of high-power, broadband infrared pulses, and it is suitable for phase-stable white light generation.
Rich Dad's Who Took My Money?: Why Slow Investors Lose and Fast Money Wins! (2004)

Most people think that simply getting a modest return on one's investments is going to take care of them forever, right through their golden years of retirement. But for lots of investors, waiting - and hoping - for a 10 per cent return on their stocks, bonds, and mutual funds is turning out to be a long and perilous wait. In this startling new book, Robert Kiyosaki shows how you can velocitise your money in such a way that you can quickly achieve financial wealth with extraordinary returns and amazing growth. Sound too good to be true? It's not - Kiyosaki and Lechter show how anyone can make the move right now.
Sink-to-sensors congestion control (2005)

The problem of congestion in sensor networks is significantly different from conventional ad-hoc networks and has not been studied to any great extent thus far. In this paper, we focus on providing congestion control from the sink to the sensors in a sensor field. We identify the different reasons for congestion from the sink to the sensors and show the uniqueness of the problem in sensor network environments. We propose a scalable, distributed approach that addresses congestion from the sink to the sensors in a sensor network. Through ns2 based simulations, we evaluate the proposed framework, and show that it performs significantly better over a basic approach which does not provide any congestion control.
Fast electrodeposition, influencing factors and catalytic properties of dendritic Cu–M (M = Ni, Fe, Co) microstructures (2015)

Dendritic Cu–M (M = Fe/Co/Ni) microstructures with good catalytic performances were successfully prepared through a rapid electrodeposition route.
Red blood cells induce hypoxic lung inflammation (2008)

Hypoxia, which commonly associates with respiratory and cardiovascular diseases, provokes an acute inflammatory response. However, underlying mechanisms are not well understood. Here we report that red blood cells (RBCs) induce hypoxic inflammation by producing reactive oxygen species (ROS) that diffuse to endothelial cells of adjoining blood vessels. Real-time fluorescence imaging of rat and mouse lungs revealed that in the presence of RBC-containing vascular perfusion, hypoxia increased microvascular ROS, and cytosolic Ca(2+), leading to P-selectin-dependent leukocyte recruitment. However, in the presence of RBC-free perfusion, all hypoxia-induced responses were completely inhibited. Because hemoglobin (Hb) autoxidation causes RBC superoxide formation that readily dismutates to H(2)O(2), hypoxia-induced responses were lost when we inhibited Hb autoxidation with CO or nitrite, or when the H(2)O(2) inhibitor, catalase was added to the infusion to neutralize the RBC-derived ROS. By contrast, perfusion with RBCs from BERK-trait mice that are more susceptible to Hb autoxidation and to hypoxia-induced superoxide production enhanced the hypoxia-induced responses. We conclude that in hypoxia, increased Hb autoxidation augments superoxide production in RBCs. Consequently, RBCs release H(2)O(2) that diffuses to the lung microvascular endothelium, thereby initiating Ca(2+)-dependent leukocyte recruitment. These findings are the first evidence that RBCs contribute to hypoxia-induced inflammation.
Differential Effects of N-Acetyl-2-aminofluorene and N-2-Aminofluorene Adducts on the Conformational Change in the Structure of DNA Polymerase I (Klenow Fragment) (2000)

The carcinogen N-acetyl-2-aminofluorene forms two major DNA adducts: the N-(2'-deoxyguanosin-8-yl)-2-acetylaminofluorene adduct (dG-C8-AAF) and its deacetylated derivative, the N-(2'-deoxyguanosin-8-yl)-2-aminofluorene adduct (dG-C8-AF). It is well established that the AAF adduct is a very strong block for DNA synthesis in vitro while the AF adduct is more easily bypassed. In an effort to understand the molecular mechanism of this phenomenon, the structure of the complex of an exonuclease-deficient Escherichia coli DNA polymerase I (Klenow fragment) bound to primer-templates containing either an AF or AAF adduct in or near the active site was probed by nuclease and protease digestion analyses. The results of these experiments suggest that positioning the AAF adduct in the polymerase active site strongly inhibits the conformational change that is required for the insertion of a nucleotide. Similar experiments with AF-modified primer-templates shows a much less pronounced effect. The inhibition of the conformational change by either adduct is not detected if they are positioned in the single-stranded part of the template just one nucleotide before the active site. These findings may explain the different abilities of these lesions to block DNA synthesis.
ADVANCED MEMS FOR HIGH POWER INTEGRATED DISTRIBUTION SYSTEMS (2006)

This paper presents a design and fabrication of advanced MEMS in high power applications. The developed MEMS is used as a circuit breaker for high power distribution systems. We designed and fabricated MxN array of low power MEMS switches to handle high power which are mass actuated by an external magnetic field.
Association of p185neu with microfilaments via a large glycoprotein complex in mammary carcinoma microvilli. Evidence for a microfilament-associated signal transduction particle. (1993)

The protein product of the neu (proto)oncogene p185neu is an analog of the epidermal growth factor receptor. Immunoblot analyses of cell surface fractions (microvilli) from the ascites 13762 rat mammary adenocarcinoma indicate that these cells contain p185neu but not epidermal growth factor receptor. Phalloidin shift velocity sedimentation analysis indicated that essentially all of the microvillar p185 co-migrated with microvillar microfilament cores when extractions were performed under microfilament-stabilizing conditions. Fractionation studies of these microvilli indicated that the association of p185 with the microfilament core is mediated by its stable interaction with a previously described transmembrane complex (TMC), composed minimally of at least four glycoproteins, a 58-kDa cytoplasmic membrane protein, and actin (Carraway, C. A. C., Jung, G., and Carraway, K. L. (1983) Proc. Natl. Acad. Sci. U. S. A. 80, 430-434). A fraction of the p185 co-purifies with a large (> 2 x 10(6) kDa) complex of the TMC glycoproteins on gel filtration of microvilli, microfilament cores, or microvillar membranes in buffer containing 1 M KCl at pH 9.5, which are conditions required for the dissociation of actin from the complex. We propose that p185-containing TMC serves as a signal transduction particle at the surface of the 13762 cells and may be a prototype for similar microfilament-associated signal-transducing complexes in other cells.
65 CHARACTERISATION OF BINDING OF THE C-TERMINAL DOMAINS OF INTIMIN PROTEIN OF ENTEROPATHOGENIC Escherichia co// (EPEC) TO HEp-2 CELLS USING FLUORESCENT MICROSPHERES (1995)

Frankel, G.; Candy, D. C. A.; Gil, S.; Fabbiani, E.; Phillips, A. D.; Dougan, G. Author Information
Using Contextual Speller Techniques and Language Modeling for ESL Error Correction (2008)

We present a modular system for detection and correction of errors made by non-native (English as a Second Language = ESL) writers. We focus on two error types: the incorrect use of determiners and the choice of prepositions. We use a decision-tree approach inspired by contextual spelling systems for detection and correction suggestions, and a large language model trained on the Gigaword corpus to provide additional information to filter out spurious suggestions. We show how this system performs on a corpus of non-native English text and discuss strategies for future enhancements. 1
Biochemical and physiological effects of chlordimeform. (1976)

Chlordimeform is a relatively new acaricide/insecticide, whose mode of action we have investigated. It appears to interfere with amine-mediated control of nervous and endocrine systems in a variety of ways. Specifically, chlordimeform causes a build-up of the amines 5-hydroxytryptamine and to a lesser extent norepinephrine in the rat brain in vivo, antagonizes the in vivo action of reserpine in the rat (reserpine depletes amine stores in the CNS), inhibits monoamine oxidase from rat liver in vitro, and causes hypotension in rabbits. In the American cockroach it directly stimulates the heart in situ, acts synergistically with tryptamine in vivo, inhibits amine-N-acetyltransferase from cockroach head in vitro, causes accumulation of indolamines in cockroaches in vivo, and blocks the stimulation of adenylate cyclase by octopamine in the cockroach CNS in situ. It also inhibits tryptamine metabolism in whole mites in vitro.
Structural Correlates of the Sensorimotor Cerebellum in Parkinson's Disease and Essential Tremor (2020)

Group differences were identified between ET and PD patients, with reductions in deep cerebellar nucleus volume in ET versus reduced lobule VI volume in PD. In ET patients, lobule VIII was negatively correlated with the severity of postural tremor. In PD patients, lobule IV was positively correlated with resting tremor and total tremor severity. We observed differences in cerebellar structure that localized to sensorimotor lobules of the cerebellum. Lobule volumes appeared to differentially relate to clinical symptoms, suggesting important clinicopathologic distinctions between these conditions. These results emphasize the role of the cerebellum in tremor symptoms and should foster future clinical and pathologic investigations of the sensorimotor lobules of the cerebellum. © 2020 International Parkinson and Movement Disorder Society.
Gold(I)‐Catalyzed Stereoselective Olefin Cyclopropanation. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
In-vitro activity of cefprozil (BMY 28100) and loracarbef (LY 163892) against pathogens obtained from middle ear fluid (1991)

We compared the in-vitro activities of cefprozil, a novel oral cephalosporin, and of loracarbef, a new oral carbacephem, with other agents against middle ear fluid isolates obtained from children with acute otitis media. These included Streptococcus pneumoniae, Haemophilus influenzae and Branhamella catarrhalis. Cefprozil activity (MIC50 and MIC90) against S. pneumoniae was 0.25 and 0.50 mg/l; against H. influenzae 8 and 16 mg/l; against B. catarrhalis 2 and 2 mg/l. Loracarbef activity (MIC50 and MIC90) against S. pneumoniae was 1 and 2 mg/l; against H. influenzae 8 and 16 mg/l; against B. catarrhalis 1 and 8 mg/l. Cefprozil was four-fold more active against S. pneumoniae than loracarbef but similar to amoxycillin, amoxycillin/clavulanate, cefaclor, cefixime, cefuroxime and trimethoprim/sulfamethoxazole (TMP/SMX). Against H. influenzae, cefprozil was similar to loracarbef and other agents through less active than TMP/SMX and cefixime. Against B. catarrhalis, cefprozil was four-fold more active than loracarbef, cefaclor and cefixime but similar to the comparative antibiotics. Cefprozil and loracarbef activities were unaffected at pH 6 and 8 or in the presence of human serum, but there was a major diminution of activity for both agents at pH 5 and at inoculum sizes greater than or equal to 10(7) cfu/ml. Cefoprozil and loracarbef have consistent activity against middle ear pathogens and further pharmacokinetic and clinical studies appear warranted.
DISCUSS ON ICD-10 ENCODING OF LEUKEMIA (2011)

Objective To investigate the easy way of ICD-10 encoding for all types of leukemia.Methods According to the pathology type of leukemia cell and differentiation,search index for encoding.Results Quickly and accurately find the code of all types' leukemia.Conclusion This method can avoid the coding error caused by finding index according to clinical diagnosis,and achieve rapid and accurate coding purposes.
C4S62: ein Bis(dithiolato)‐Brückenligand für die Herstellung von anorganischen Halbleiterpolymeren (1995)

Planar und gut polarisierbar ist die dianionische Schwefelkohlenstoffverbindung 1 , die mit Metallsalzen zu anorganischen Polymeren wie Cu 2 C 4 S 6 und NiC 4 S 6 , die Halbleitereigenschaften aufweisen, reagiert. Das Ni‐Koordinationspolymer bildet wohl eindimensionale bandartige Stränge aus kantenverknüpften, quadratisch‐planaren Komplexen wie 2 . magnified image
Cone-Specific Promoters for Gene Therapy of Achromatopsia and Other Retinal Diseases (2015)

Adeno-associated viral (AAV) vectors containing cone-specific promoters have rescued cone photoreceptor function in mouse and dog models of achromatopsia, but cone-specific promoters have not been optimized for use in primates. Using AAV vectors administered by subretinal injection, we evaluated a series of promoters based on the human L-opsin promoter, or a chimeric human cone transducin promoter, for their ability to drive gene expression of green fluorescent protein (GFP) in mice and nonhuman primates. Each of these promoters directed high-level GFP expression in mouse photoreceptors. In primates, subretinal injection of an AAV-GFP vector containing a 1.7-kb L-opsin promoter (PR1.7) achieved strong and specific GFP expression in all cone photoreceptors and was more efficient than a vector containing the 2.1-kb L-opsin promoter that was used in AAV vectors that rescued cone function in mouse and dog models of achromatopsia. A chimeric cone transducin promoter that directed strong GFP expression in mouse and dog cone photoreceptors was unable to drive GFP expression in primate cones. An AAV vector expressing a human CNGB3 gene driven by the PR1.7 promoter rescued cone function in the mouse model of achromatopsia. These results have informed the design of an AAV vector for treatment of patients with achromatopsia.
Identification of Active Site Residues in Glycosidases by Use of Tandem Mass Spectrometry (2003)

The glycosidases are a class of enzymes that are responsible for the hydrolysis of glycosidic bonds. Such glycosidic linkages occur in a wide range of contexts, including polysaccharides, oligosaccharides, glycolipids, glycoproteins, lipopolysaccharides, proteoglycans, saponins, and a range of other glycoconju-gates. Corresponding to this diverse collection of substrates there is a very large assortment of glycosidases responsible for their selective hydrolysis. Amino acid sequences are now available for well over 2000 of these enzymes, and these have been arranged into families on the basis of sequence similarities (1–4). At the last count (November 1999) there were 76 such families, and a regularly updated list of these is readily available at the URL http://afmb.cnrs-mrs.fr/ R~pedro/CAZY/db.html . A large amount of effort has been expended on structural studies of these enzymes in the past 10 yr with the result that three-dimensional X-ray crystal structures are now available for representatives of at least 27 of these families (4–6). These structures are remarkably diverse, with monomer sizes ranging from approx 14,000 to 170,000 Daltons, and compositions ranging from essentially completely α-helical to almost exclusively β-sheet. The reasons for this diversity are probably twofold; the diverse nature of the substrates themselves, and different evolutionary pathways to the construction of an active site.