gebhart/patrepeval huggingface dataset:
ウズラ卵白リゾチームのアミノ酸配列 (2) ブロムシアン分解断片のトリプシン及びキモトリプシンペプチドについて (1975)

departmental bulletin paper
Tunnel placement in anterior cruciate ligament (ACL) reconstruction: quality control in a teaching hospital (2006)

Correct placement of the femoral and tibial bone tunnels is decisive for a successful anterior cruciate ligament (ACL) reconstruction. Our method of tunnel placement was evaluated as part of quality control at a teaching hospital. The emphasis was placed mainly on investigating the influence of surgical experience on tunnel placement, and the effect of tunnel position on the clinical outcome. Seventeen surgeons with different levels of experience (between 0 and >150 ACL reconstructions) performed endoscopic ACL repair in uniform technique from August 2000 to August 2003 on 50 patients (18 women, 32 men, age range 18-43 years). The patients were available to clinical and radiological follow-up after an average of 19 months. The clinical outcome was classified according to the International Knee Documentation Committee (IKDC) standard evaluation form. The femoral tunnel was evaluated according to the quadrant method of Bernard and Hertel; the position of the tibial bone tunnel was assessed according to the criteria of Stäubli and Rauschnig. The IKDC score revealed 47 (94%) patients with a normal (A) or nearly normal (B) knee joint at follow-up. According to the quadrant method, the femoral canal was situated on average at 29% in the saggital plane. The tibial tunnel was situated on average at 43% of the a.p. diameter of the tibial condyle. Statistical analysis of our data showed no significant correlation between tunnel placement and surgical expertise. However, a highly significant correlation was found (alpha<0.01) between the femoral position of the tunnel in the sagittal plane and the IKDC score. The more anterior the femoral canal, the poorer the IKDC score. The method of tunnel placement in ACL reconstruction being investigated here only showed slight dependence on surgical experience, whereby good short-term clinical outcomes were achieved. Therefore, the method is suitable for application at a teaching hospital. A far too anterior femoral tunnel placement will probably lead to a decline in the clinical result.
A performance study of robust distributed load sharing strategies (1994)

In this paper, we examine a set of load sharing strategies that are robust to the unreliable state information that is often present in a distributed database system. In this environment, sites must solve the problem of how alternative sites should be selected to process incoming transactions, given that the information on which the decision is based exhibits varying degrees of obsolescence. A set of regression-based adaptive strategies is examined in which a feedback mechanism is used to compensate for obsolete information. Transaction response time under the different adaptive strategies is evaluated, and the reasons for these performance differences discussed. The key characteristic of the best regression strategy is that transaction site affinity is taken into consideration when adjusting for the effect of information obsolescence.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Can we go towards true 3-D architectures? (2011)

Thanks to recent technology advances, the exploration of the vertical dimension has been shown to be more than a dream for designers. Among those technologies, the vertical transistor has not been exploited yet. This paper describes a novel implementation of logic gates fully benefiting of nanowire-based vertical transistors embedded within the metal lines. The logic design in this technology is explored and its performance is evaluated. A comparison made on an equivalent technology node shows that our cells reduce area and delay by a factor of 31x and 2x respectively. Large reconfigurable logic circuits have been benchmarked showing an improvement of area and delay by 46% and 48% on average.
IFNγ induces Bcl3 expression by JAK1/STAT1/p65 signaling, resulting in increased IL‐8 expression in ovarian cancer cells (2023)

We have recently shown that IFNγ, produced during cancer therapy, induces expression of the Bcl3 proto-oncogene in ovarian cancer (OC) cells, resulting in their increased proliferation, migration, and invasion, but the mechanisms are unknown. Here, we demonstrate that the IFNγ-induced Bcl3 expression is dependent on JAK1 and STAT1 signaling, and on p65 NFκB. Furthermore, the IFNγ-induced Bcl3 expression is associated with an increased occupancy of Ser-727 phosphorylated STAT1 and acetylated histone H3 at the Bcl3 promoter. Our data indicate that Bcl3 promotes expression of the pro-inflammatory chemokine interleukin-8 (IL-8) in OC cells. These findings identify Bcl3 as a novel target of IFNγ/JAK1/STAT1 signaling and suggest that targeting the JAK1/STAT1 pathway may suppress IFNγ-induced Bcl3 expression in OC.
Understanding Fluorescence Quenching in Polymers Obtained by RAFT (2007)

Reversible addition−fragmentation chain transfer (RAFT) polymerization is a versatile process to obtain polymers with controlled architecture and molecular weight from a large variety of monomers. This appears to be a very attractive method for the synthesis of fluorescent polymers for different applications. However, fluorescent polymers obtained by RAFT are known to suffer strong fluorescence quenching. Here, we report the quenching of coumarin 343 (C343) fluorescence by four different chain transfer agents (CTA) used in RAFT polymerization: carboxymethyl dithiobenzoate (CMDB), tert-butyl dithiobenzoate (tBDB), menthonyl dithiobenzoate (MDB), and bis(3-methylbutyl)-2-(thiobenzoylthio)succinate (MBTS). The quenching ability of these CTAs was compared with that of a macroCTA (poly(DcA)−MBTS) obtained from the RAFT polymerization of N-decylacrylamide (DcA) using MBTS as chain transfer agent. The results of stationary and time-resolved fluorescence measurements of C343 with the different CTA and macroCTA can be interpreted with a single kinetic model, which considers the reversible formation of a C343−CTA exciplex and both static and dynamic quenching of C343. The photophysical properties of tert-butyl mercaptan (tBM), resulting from the aminolysis of the tBDB dithioester, were also studied using the same experimental conditions, confirming that the thiol group does not quench the C343 fluorescence. This was further tested by converting poly(DcA)−MBTS to the corresponding thiol-ended chain, eliminating the fluorescence quenching of coumarin previously observed.
Electrostatic Elastomer Devices for Reconfigurable High-Density Microfluidics. (2008)

Components and systems for the scalable, very large-scale integration (VLSI) of thousands of microfluidic devices into Micro Total Analysis Systems (μTAS) are the fo-cus of much ongoing research. Most solutions to date have focused on either a) the scal-ing and modification of conventional pneumatically-driven elastomer microfluidics or b) the development of electrically or magnetically addressable fluidic components and sys-tems. Although these technologies have each solved the integration problem partially, they still leave something to be desired such as lack of on-chip power or degradation in chip performance due to cross contamination. This thesis presents the design, fabrication, and characterization of an electrostati-cally actuated user-reconfigurable elastomer microfluidic system intended for VLSI mi-crofluidics. Capacitor plates form top (deformable) and bottom of the micro chan-nel/chamber, facilitating gap-closing actuation. Device fabrication followed standard mi-cromaching process. We also present experimental results of flow and pressure data for valves, pumps and demonstrate various multi-component configurations of the system. The presented technology is compatible with standard polydimethylsiloxane (PDMS) mi-crofluidics, has actuation voltages low enough to be driven by commercial CMOS IC’s and can be used to displace aqueous, gaseous and lipid phases. By adding thin film metal flexures into the PDMS polymer, individual elastomer channels were made to self-close without the use of pneumatics via the application of 10 – 20 V, 5 MHz signals synthesized digitally by a microcontroller and a radio-frequency amplifier IC. These valves were integrated into discrete micro valve and three-valve peristaltic micro pumps. A single valve was able to hold 6 psi pressure, and the peristaltic pump had a flow rate 4.4 valve-volume/min (1 - 2 nL/min), depending on the actuation frequency and device configuration. Further, these valves were arranged into hexagonal or quadricular arrays with 75% fill factor. During use, valves were selected to be permanently closed, permanently open or addressable; this allowed for the on-the-fly determination of channels, valves and pumps. We demonstrated various multi-component configurations of the system: distributed valving, fluid switching, flow splitting and mix-ing. The primary contribution of this technology is to provide a scalable reconfigurable liquid manipulation platform for the very large scale integration of μTAS.
Design and Analysis of Practical Public-Key Encryption Schemes Secure against Adaptive Chosen Ciphertext Attack (2003)

A new public-key encryption scheme, along with several variants, is proposed and analyzed. The scheme and its variants are quite practical and are proved secure against adaptive chosen ciphertext attack under standard intractability assumptions. These appear to be the first public-key encryption schemes in the literature that are simultaneously practical and provably secure.
SmartCues: A Multitouch Query Approach for Details-on-Demand through Dynamically Computed Overlays (2018)

Details-on-demand is a crucial feature in the visual information-seeking process but is often only implemented in highly constrained settings. The most common solution, hover queries (i.e., tooltips), are fast and expressive but are usually limited to single mark (e.g., a bar in a bar chart). 'Queries' to retrieve details for more complex sets of objects (e.g., comparisons between pairs of elements, averages across multiple items, trend lines, etc.) are difficult for end-users to invoke explicitly. Further, the output of these queries require complex annotations and overlays which need to be displayed and dismissed on demand to avoid clutter. In this work we introduce SmartCues, a library to support details-on-demand through dynamically computed overlays. For end-users, SmartCues provides multitouch interactions to construct complex queries for a variety of details. For designers, SmartCues offers an interaction library that can be used out-of-the-box, and can be extended for new charts and detail types. We demonstrate how SmartCues can be implemented across a wide array of visualization types and, through a lab study, show that end users can effectively use SmartCues.
REPERCUSSÕES LOCAIS DAS MUDANÇAS CLIMÁTICAS GLOBAIS: URBANIZAÇÃO, GOVERNANÇA E PARTICIPAÇÃO COMUNITÁRIA (2014)

Os desafios na governança das cidades estão crescendo em todo o mundo com os novos riscos e vulnerabilidades associados às mudanças climáticas globais. A noção de que os governos locais desempenham papel chave na formulação e implementação de políticas de mitigação e adaptação a estas alterações ambientais, é confirmada pelo visível aumento das demandas por ações concretas na escala urbana. Cidades de todas as partes do mundo deverão realizar intervenções para evitar as consequências potenciais das mudanças do clima nas próximas décadas. Em um contexto de oportunidades e desafios, a participação popular e o envolvimento das comunidades são fundamentais para o sucesso de políticas urbanas. O estudo trás uma série de reflexões sobre a mitigação e adaptação nas cidades, a importância da escala nos estudos urbanos sobre as mudanças do clima, a governança local e o envolvimento de comunidades no planejamento e na gestão de impactos. Cidades bem administradas têm maior capacidade de se adaptar às mudanças climáticas globais e aos desdobramentos disso nas próximas décadas. Trabalhos desta natureza podem contribuir para que as cidades sejam mais bem sucedidas e sustentáveis, articulando ações para a proteção de seus habitantes. Nesse sentido, ações voltadas para a superação dos desafios urbanos da mudança do clima devem ter atenção especial às políticas com maior repercussão local, superando problemas ambientais básicos que ameaçam a saúde e a vida.
LARP6 Meets Collagen mRNA: Specific Regulation of Type I Collagen Expression (2016)

Type I collagen is the most abundant structural protein in all vertebrates, but its constitutive rate of synthesis is low due to long half-life of the protein (60-70 days). However, several hundred fold increased production of type I collagen is often seen in reparative or reactive fibrosis. The mechanism which is responsible for this dramatic upregulation is complex, including multiple levels of regulation. However, posttranscriptional regulation evidently plays a predominant role. Posttranscriptional regulation comprises processing, transport, stabilization and translation of mRNAs and is executed by RNA binding proteins. There are about 800 RNA binding proteins, but only one, La ribonucleoprotein domain family member 6 (LARP6), is specifically involved in type I collagen regulation. In the 5'untranslated region (5'UTR) of mRNAs encoding for type I and type III collagens there is an evolutionally conserved stem-loop (SL) structure; this structure is not found in any other mRNA, including any other collagen mRNA. LARP6 binds to the 5'SL in sequence specific manner to regulate stability of collagen mRNAs and their translatability. Here, we will review current understanding of how is LARP6 involved in posttranscriptional regulation of collagen mRNAs. We will also discuss how other proteins recruited by LARP6, including nonmuscle myosin, vimentin, serine threonine kinase receptor associated protein (STRAP), 25 kD FK506 binding protein (FKBP25) and RNA helicase A (RHA), contribute to this process.
Treatment of Cerebral Aneurysms With Flow Divertors: Long Term Results in an In Vivo Model (2007)

Subarachnoid hemorrhagic stroke is a devastating illness with a 30-day mortality rate of 45% and is mostly caused due to the rupture of an intracranial aneurysm. Although these aneurysms are currently treated surgically by clipping, or, endovascularly by coiling and stent-assisted coiling, the feasibility of successfully treating aneurysms solely by the placement of an intravascular flow-diverting mesh across the aneurysm neck was established more than a decade ago [1]. Flow divertors disrupt the momentum exchange between the parent artery and aneurysm and significantly reduce intraaneurysmal hydrodynamic vorticity. The resultant flow stasis promotes thrombus formation within the aneurysm sac, which eventually matures into fibrotic tissue, leading to the exclusion of the aneurysm from the circulation. With the increased use of stents in the intracranial circulation, cases where coiling is not feasible, or is staged as a secondary procedure, are providing clinical evidence of the successful treatment of aneurysms with stents alone [2,3]. Such reports are sporadic and, moreover, the devices used are not designed to be flow divertors. Methodological evidence of the performance of appropriately designed flow divertors in treating cerebral aneurysms is currently unavailable.
Cover Feature: Mechanistic Insights into the Formation of δ‐Lactones by Cerium‐Catalyzed Aerobic Coupling of β‐Oxoesters with Enol Acetates (Eur. J. Org. Chem. 6/2021) (2021)

The Cover Feature shows the excited cuckoo dashing out of his (radical) clock, because the mechanism of the cerium-catalyzed radical coupling reaction of β-oxoesters, enol acetates, and dioxygen was finally elucidated by the introduction of cyclopropyl substituents as radical clocks. Furthermore, the introduction of stereocenters in the starting materials causes a stir, since the 1,2-alkyl shift within the endoperoxidic oxycarbenium intermediate was proved to proceed with retention of configuration. More information can be found in the Full Paper by J. Christoffers et al.
Linear electro-optic properties of YCa_4O(BO_3)_3 (2003)

We have characterized the effective linear electro-optic coefficients of YCa4O(BO3)3 (YCOB) relative to KH2PO4 and KD2PO4 at 632.8 nm. We measured a maximum r(eff) value of 10.8 +/- 1.4 pm/V for YCOB in a transverse electric field configuration for propagation along the X or the alpha dielectric axis, with the electric field applied along the Z or the gamma dielectric axis. We also found effective coefficients of 10.7 +/- 1.0 and 3.4 +/- 0.4 pm/V for YCOB in longitudinal configurations. The remaining values of r(eff) for various transverse applied voltages were found to be less than 3 pm/V. The excellent thermomechanical properties of this crystal, coupled with moderate electro-optic coefficients, make YCOB and its isomorphs potential candidates for use as high-average-power electro-optic switches.
[Pharmacokinetics of S-1]. (2006)

S-1 is an attractive oral fluorouracil antitumor drug, which is being called "a self-rescuing drug". This novel oral fluoropyrimidine is combined with three pharmacological agents: tegafur (FT) which is a prodrug of 5-fluorouracil (5-FU), 5-chloro-2,4-dihydroxypyridine (CDHP) which inhibits dihydropyrimidine dehydrogenase (DPD) activity, and potassium oxonate (Oxo) which reduces gastrointestinal toxicity. Phase I and an early phase II clinical trials were performed about ten years ago, and these results had already been introduced to the Journal "Clinical Cancer Research Vol. 5, pages 2000-2005, 1999". The data of this article in this journal was referred from the results of the figures and tables based on the above trial. Most of the authors in this article have contributed on that pharmacokinetics study and published the above manuscripts. In that study, the pharmacokinetics of 5-FU, intact FT, CDHP and Oxo after administration of the standard dose of S-1 had been performed. These studies were carried out at two hospitals, Department of Surgery (Section 1) Sapporo Medical University and Chemotherapy Cancer Center, Cancer Institute Hospital and Japanese Foundation for Cancer Research (Ohtsuka). The number of patients accepted for this trial is twelve, 5 patients with gastric cancer, 4 with colorectal cancer and 3 with breast cancer. Single administration trial was referred to all patients, but consecutive administration trial was limited to ten patients. The results of plasma concentration, Cmax, Tmax, AUC0-14, and T1/2 of 5-FU, FT, CDHP, and Oxo were ascertained in details. It was a surprise that the indicated data was very similar to that of the intravenous 5-FU continuous infusion. Therefore, the low dose administration of 5-FU (FT) as S-1 may result in good antitumor effects with minimum adverse effects to the patients.
A Short Synthesis of a Novel Ring-Expanded Purine and Its Nucleoside Analogue Containing the Imidazo[4,5-e][1,3]diazepine Ring Skeleton with Multiple Amino Substituents Attached to the 7-Membered Ring (1994)

Abstract The synthesis of 4,6,8-triaminoimidazo[4,5-e][1,3]diazepine (1) and its nacleoside analogue (6) are reported. The heterocycle was prepared in a single step by condensation of 4,5-dicyanoimidazole with guanidine. The 5,7-fused ring structure of 1 was distinguished from the other possible 5:5-fused isomer 2 by preparing the 15N-labeled heterocycle (1∗) and exploring its 15N-1H coupling patterns in both 1H and 15N NMR spectra. These spectral patterns also enabled establishment of the triamino tautomeric form of 1 as assigned. Compound 1, a novel ring-expanded (“fat”) analogue of purine, is anticipated to be planar and aromatic as predicted by molecular modeling. The 1 -benzyl analogue (4), a protocol for the ribosyl analogue 6, was similarly prepared from 1-benzyl-4,5-dicyanoimidazole. The nucleoside 6 was prepared by the modified Vorbrülggen ribosylation of 1. The position of ribosylation was unequivocally established by an unambiguous synthesis of 6 from condensation of 1 -(2′,3′,5-tri-O-benzoyl-β-D-ribofuranosyl)-4,5-dicyanoimidazole (7) with guanidine in a solution of sodium methoxide in methanol. The nucleoside 7 was prepared by the Vorbrüggen ribosylation of 4,5-dicyanoimidazole.
BREEDING AND GENETICS Effect of Chromosome Substitutions from Gossypium barbadense L. 3-79 into G. hirsutum L. TM-1 on Agronomic and Fiber Traits (2004)

Pima cottons (Gossypium barbadense L.) possess fiber properties that are superior to the more widely grown Upland cottons (G. hirsutum L.). Incorporating the superior fiber properties from Pima into Upland cotton has generally not achieved stable introgression because of genome incompatibility. Using a set of stable lines (CS-B) containing chromosome or chromosome arm sub-stitutions from G. barbadense (3-79) backcrossed into a G. hirsutum (TM-1) background, traits from the TM-1 parent that varied significantly could be attributed to genes in the substituted chromosome, to other residual 3-79 chromatin material, and/or their interaction with the other
Structural relationships among mouse and human immunogtobulin VHgenes in the subgroup III (1983)

The mouse VHIII subgroup is composed of four families which share sequence homology. We isolated a VH germ-line genomic clone, which cross hybridizes with a cDNA probe from one of these families, derived from a myeloma secreting an antigalactan antibody. We report here the nucleotide sequence of the cross hybridizing gene and show that very likely it has an anti-sheep red blood cell specificity. Comparison of its nucleotide sequence with those of the three other VHIII families shows that these genes share segmental homologies of variable lengths. This suggests that interchanges of sequence blocks between VH genes could be an important evolutionary mechanism for diversifying the germ-line repertoire. The strong homology (82%) with human VHIII genes suggests that efficient antibody sequences are strongly conserved. This conservation of homology is particularly striking when compared to the more limited homology (63%) between mouse and human C kappa genes.
Distribution of electronic mail over the broad-band party-line communications network (1970)

Cable television (CATV) is unique in that it is the only wire, besides telephone, with potential access to 80 million customers. Many new services have been proposed to utilize this access-from meter reading to transmission of an entire book in seconds. The author postulates that electronic mail is the market CATV should pursue and describes the market potential, a system design in some detail, and an estimate of the costs involved. An intriguing result of this analysis is the possibility of sending mail electronically for only 10 cents a letter.
Microsoft Project 2010 Inside Out (2011)

Conquer Microsoft Project 2010from the inside out! You're beyond the basics, so dive right in and really put your project management skills to work! This supremely organized reference packs hundreds of timesaving solutions, troubleshooting tips, and workarounds. It's all muscle and no fluff. Discover how the experts tackle Project 2010and challenge yourself to new levels of mastery.Take charge of the project triangletime, money, and scopeto balance your plan Enable collaboration among team members, sponsors, and other project stakeholders Manually schedule tasks or use the automatic scheduling engine Track and control your project using earned value analysis Create pivot views of project data with Microsoft Excel 2010 and Visio 2010 Manage project activities in an enterprise project-management environment Apply your experience to future projects by creating your own custom templates
AICAR inhibits adipocyte differentiation in 3T3L1 and restores metabolic alterations in diet-induced obesity mice model (2006)

This study suggests that AICAR inhibits adipocyte differentiation via downregulation of expression of adipogenic factors in vitro and reduces adipose tissue content in DIO mice by activating expression of PGC1alpha without inhibiting adipocyte-specific transcription factors in DIO mice.