gebhart/patrepeval huggingface dataset:
Simulation of a Multistage Fractured Horizontal Well with Finite Conductivity in Composite Shale Gas Reservoir through Finite-Element Method (2016)

Different from oil properties, gas properties (gas formation factor, viscosity, and Z-factor, etc.) have nonlinear behaviors with pressure changes. However, many scholars use the average pressure or pseudopressure concept to simplify the phenomenon for easier solutions. Gas flow in shales is believed to be a complex process with multiple flow mechanisms including continuum flow, slip flow, diffusion, ad-desorption, and the stress sensitivity of fractures (natural or induced) permeability in multiscaled systems of nano- to macroporosity. Multistage hydraulic fracturing not only creates the stimulated rock volume (SRV) to improve production but also makes the flow in shales more complex. In this work, a rectangular composite model for a multistage fractured horizontal well (MFHW) with finite conductivity in shale gas considering the multiple flow mechanisms and multi-nonlinearities is developed. Comparing with the existing models for MFHW in shale, the model presented here takes strong nonlinearity of gas properties, hydraulic fracture asymmetry, fracturing efficiency, and SRV region into account, which is more in line with field practice. Numerical simulation of fully implicit control volume finite element (CVFE) based on unstructured 3D tetrahedral mesh is proposed to obtain the production performance of MFHW. Sensitivity analysis focuses on the effects of nonlinearity, Langmuir volume, stress sensitivity, finite conductivity, and SRV type on the production performance. The research and the numerical results obtained in this work can provide theoretical guidance to efficient and scale development for shale gas reservoir.
Analytical Validation and Capabilities of the Epic CTC Platform: Enrichment-Free Circulating Tumour Cell Detection and Characterization (2015)

Abstract non disponibile
Melanoma: Prognostic Factors and Factors Predictive of Response to Therapy (2019)

With increasing knowledge, the understanding of melanoma stage-specific prognostic features should further improve. Moreover, ongoing trials should provide increasing evidence on the best use of biomarkers to help select the most appropriate patients for tailored treatment with immunotherapies and targeted therapies.
In Silico Ultrafast Nonlinear Spectroscopy Meets Experiments: The Case of Perylene Bisimide Dye (2021)

Spectroscopy simulations are of paramount importance for the interpretation of experimental electronic spectra, the disentangling of overlapping spectral features, and the tracing of the microscopic origin of the observed signals. Linear and nonlinear simulations are based on the results drawn from electronic structure calculations that provide the necessary parameterization of the molecular systems probed by light. Here, we investigate the applicability of excited-state properties obtained from linear-response time-dependent density functional theory (TDDFT) in the description of nonlinear spectra by employing the pseudowavefunction approach and compare them with benchmarks from highly accurate RASSCF/RASPT2 calculations and with high temporal resolution experimental results. As a test case, we consider the prediction of femtosecond transient absorption and two-dimensional electronic spectroscopy of a perylene bisimide dye in solution. We find that experimental signals are well reproduced by both theoretical approaches, showing that the computationally cheaper TDDFT can be a suitable option for the simulation of nonlinear spectroscopy of molecular systems that are too large to be treated with higher-level RASSCF/RASPT2 methods.
Impact of Complete Inhibition of Viral Replication on the Cellular Immune Response in Chronic Hepatitis B Virus Infection (1996)

Interferon alfa (IFN-alpha) treatment is effective in only a proportion of patients with chronic hepatitis B virus (HBV) infection. The mechanisms for therapeutic failure remain unknown but high levels of HBV replication are known to inhibit the immunopotentiating effects of IFN-alpha. In nine patients with chronic hepatitis B not responding to IFN-alpha monotherapy, we determined the virus-specific T-helper-cell responses during two consecutive therapeutic regimens: IFN-alpha alone and IFN-alpha in combination with a new potent inhibitor of HBV replication, lamivudine. By comparing the results obtained during the initial IFN-alpha monotherapy to those during the combination treatment, it was investigated whether complete inhibition of virus replication will enhance the interferon-induced immunoreactivity to HBV. Despite the rapid reduction to undetectable serum HBV DNA in all nine patients during the combination treatment, none sustained permanent hepatitis B e antigen (HBeAg) clearance during subsequent 12-month follow-up. HLA class II-restricted T-helper-cell responses to hepatitis B core antigen (HBcAg) showed no difference during IFN-alpha monotherapy and during the combination of lamivudine plus IFN-alpha. In contrast, a delayed T-cell activation occurred after a rebound in serum HBV DNA postcombination treatment, which lead to increased hepatocytolysis. These findings suggest that the profound inhibition of HBV replication by a nucleoside analogue does not restore the impaired virus-specific T-cell response in chronic HBV infection.
Electrical Transmission Characteristics of Marine Seismic Cable (1981)

The transmission line response of a marine seismic survey cable is analyzed. A new amplifier design yields significant improvement in compensating for the undesirable effects of the transmission line.
O4‐06‐04: Mediterranean diet adherence is associated with less cerebral amyloid accumulation over time: Data from the australian imaging, biomarkers, and lifestyle study of ageing (2015)

Identification of lifestyle and dietary modifications which prevent or delay cognitive decline and Alzheimer's disease (AD) would confer significant social and economic benefit. Yet, there is a relative lack of large-scale longitudinal investigations of lifestyle-related factors impacting cognitive decline and AD-related pathology. The Mediterranean diet (MeDi), has been widely recognised as a healthy eating model due to its correlation with low morbidity and mortality for many chronic diseases. In the context of AD, accumulating research including our own has linked MeDi adherence with slower cognitive decline and reduced risk of AD. However, only one study to date has examined the relationship between MeDi adherence and cerebral amyloid load, with the authors reporting reduced cerebral amyloid load cross-sectionally among individuals with high MeDi adherence. There is a critical need to further explore the relationship between MeDi and brain amyloid levels using longitudinal data collected from a well-characterised ageing cohort. We report on data collected over 36 months from cognitively healthy control participants (n=119) of the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study of Ageing. The Cancer Council of Victoria Food Frequency Questionnaire was used to generate a MeDi score for each participant at baseline. Cerebral amyloid load was quantified by Pittsburgh Compound B positron emission tomography at baseline, 18 and 36 months. The relationship between MeDi adherence and cerebral amyloid load was evaluated longitudinally using Analysis of Variance, correlations and Generalised Linear Models (age, gender, education and Apolipoprotein E ε4 carriage were included in the models). Individuals with high MeDi adherence demonstrated less cerebral amyloid accumulation over 36 months compared to those with low adherence (0.04 vs. 0.08 mean change cerebral amyloid load respectively; p=0.008). To our knowledge, this is the first study to assess the relationship between MeDi adherence and cerebral amyloid burden longitudinally. Our results suggest that MeDi adherence is associated with reduced cerebral AD pathology. When our results are considered collectively with previous data linking the MeDi to slower cognitive decline, it appears that MeDi adherence warrants further investigation in the quest to delay AD onset.
Contour Adaptive Image Coding (2006)

This paper presents a new image coding framework that separates singularities based on their topological dimension: point singularities (0D), line singularities (1D) and plane singularities (2D). Contours are smooth curves corresponding to line singularities and boundaries of plane singularities. We propose to directly code contour locations in the spatial domain and spatially adapt the bases to approximate various singularities conditioned on contour locations. The key to the success of our forward adaptive coding lies in the exploitation of contour geometry while achieving spatial adaptation. Preliminary experimental results are used to demonstrate the potential of our approach.
Supplementary Tables S1-S5 from The p53 Tumor Suppressor Network Is a Key Responder to Microenvironmental Components of Chronic Inflammatory Stress (2023)

Supplementary Tables S1-S5 from The p53 Tumor Suppressor Network Is a Key Responder to Microenvironmental Components of Chronic Inflammatory Stress
Decompressive Surgery for Typical Lumbar Spinal Stenosis (2001)

Between 1991 and 1992, 103 consecutive patients (average age, 65 years) underwent decompressive surgery for treatment of typical lumbar spinal stenosis. Clinical results at 1-year followup revealed that four patients had revision surgery. At 2- to 5-years followup, there were no additional revision surgeries. Two patients underwent revision surgery for a deep infection, and two underwent revision surgery for a superficial infection. Outcome results showed that 77 patients completed the questionnaire, 15 were lost to followup and 11 died. Postoperative results showed that 64 of 77 patients had no or mild pain, 72 of 77 patients stated that they were satisfied or somewhat satisfied with their overall results of surgery, and 73 of 77 were satisfied with pain relief. Younger patients had greater improvement in function and a greater reduction in severity scores. However, satisfaction was similar in both groups. Survivorship results (failure was revision surgery) showed at the end of 4 years, a patient had a 95% chance of not having revision surgery. Statistically, there was no association between outcome and cofactors such as scoliosis, spondylolisthesis, number of levels decompressed, discectomy, or smoking. Satisfaction rates for older patients were similar to patients younger than 65 years although physical function scores and severity scores were less.
ChemInform Abstract: Pyrochlore to Fluorite Transition: The Y2(Ti1‐xZrx)2O7 (0.0 ≤ x ≤ 1.0) System. (2013)

Abstract The title system is characterized by neutron powder diffraction.
Bidirectional overadaptation achieved by executing leftward or rightward head movements during unidirectional rotation. (1978)

We consider here both fault identification and fault signal estimation. Regarding fault identification, we seek either exact or almost fault identification. On the other hand, regarding fault signal estimation, we seek either 2 optimal, 2 suboptimal or 8 suboptimal estimation. By appropriate combination of these two aspects, we formulate five different fault identification and fault signal estimation problems. We analyse and synthesize appropriate residual generators for fault identification and estimators which generate fault signal estimates for all these problems. Solvability conditions for all these problems are given. Also, for each of these problems, the architecture of integrating the residual generator that isolates the fault and estimators that estimate the fault signals is developed.
Elektronen im starren Gitter (1993)

Wir betrachten ein Kristallgitter, dessen Atome räumlich streng periodisch und ruhend angeordnet sind. Wir sehen also im Moment von Gitterschwingungen ab. Jedes einzelne Elektron im Kristallgitter bewegt sich im elektrischen Felde der Atomkerne und aller übrigen Elektronen. Es handelt sich also um ein sehr kompliziertes Mehrteilchenproblem. In der Blochschen Theorie der Kristallelektronen wird dieses Vielelektronenproblem auf das Problem eines einzigen Elektrons durch folgende Betrachtung reduziert. Wir stellen uns vor, daß die Wirkung der Atomkerne und aller übrigen Elektronen auf das herausgegriffene Elektron in pauschaler Weise durch die Angabe eines fest vorgegebenen Potentialfeldes V(x) beschrieben werden kann. Da die Gitterbausteine streng periodisch angeordnet sind, muß dieses Potential dann selbst diese Gitterperiodizität besitzen (vgl. Fig. 25).
Alzheimer??s disease: tau proteins, the promoting factors of microtubule assembly, are major components of paired helical filaments (1987)

A rabbit antiserum was raised against paired helical filaments (PHF). This antiserum stains specifically neurofibrillary tangles (NFT) at the light-microscopic level and PHF at the electron-microscopic level in sections of Alzheimer neocortex and hippocampus. We studied the nature of the antigens recognized by this antiserum by immunocytochemistry, immunoblots and immunoadsorption. These approaches showed that the anti-PHF specifically labels a set of low molecular weight 65-50 kDa microtubule-associated proteins, named Tau proteins, which are promoting factors of microtubule assembly. Furthermore, antisera against Tau proteins stained NFT. It is concluded that neurofibrillary tangles are very likely composed of aggregated Tau proteins. This process might be due to an abnormal Tau protein synthesis or to an unknown lesion of certain pyramidal neurons leading to an aggregation of Tau proteins.
SARS-CoV-2 Infected Pediatric Cerebral Cortical Neurons: Transcriptomic Analysis and Potential Role of Toll-like Receptors in Pathogenesis (2021)

Different mechanisms were proposed as responsible for COVID-19 neurological symptoms but a clear one has not been established yet. In this work we aimed to study SARS-CoV-2 capacity to infect pediatric human cortical neuronal HCN-2 cells, studying the changes in the transcriptomic profile by next generation sequencing. SARS-CoV-2 was able to replicate in HCN-2 cells, that did not express <i>ACE2</i>, confirmed also with Western blot, and <i>TMPRSS2</i>. Looking for pattern recognition receptor expression, we found the deregulation of scavenger receptors, such as SR-B1, and the downregulation of genes encoding for Nod-like receptors. On the other hand, <i>TLR1</i>, <i>TLR4</i> and <i>TLR6</i> encoding for Toll-like receptors (TLRs) were upregulated. We also found the upregulation of genes encoding for ERK, JNK, NF-κB and Caspase 8 in our transcriptomic analysis. Regarding the expression of known receptors for viral RNA, only RIG-1 showed an increased expression; downstream RIG-1, the genes encoding for TRAF3, IKKε and IRF3 were downregulated. We also found the upregulation of genes encoding for chemokines and accordingly we found an increase in cytokine/chemokine levels in the medium. According to our results, it is possible to speculate that additionally to ACE2 and TMPRSS2, also other receptors may interact with SARS-CoV-2 proteins and mediate its entry or pathogenesis in pediatric cortical neurons infected with SARS-CoV-2. In particular, TLRs signaling could be crucial for the neurological involvement related to SARS-CoV-2 infection.
Effect of wavelet bases on compressing digital mammograms (1995)

The purposes of this paper are four-fold: (a) develop a variety of wavelet methods, including standard, hyperbolic, and adaptive wavelet bases, for the compression of high-resolution digital mammograms, (b) apply different levels of compression to the images and determine the dependence of the information loss on the compression ratio, (c) determine qualitatively the types of artifacts and errors introduced to the compressed reconstructed images by the various wavelets and make a relative comparison, and (d) discriminate among the various wavelet bases and select those worthy of further analysis and study.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Fortgeschrittene Produktionssysteme im Wandel der Arbeitswelt (1986)

Arbeit ist für den Menschen von existentieller Bedeutung. Prinzipiell kann Arbeit mit menschlichem Tun, mit Leben durchaus identifiziert werden. Die Arbeitswelt gehört zur Lebenswelt der Menschen. Arbeit bereichert immer dann das Leben, wenn Erfolg sie begleitet und persönliches Können gefordert wird. Arbeit wird jedoch vom Menschen auch ambivalent empfunden: Physische Überforderung macht die Grenzen menschlicher Arbeitsleistung deutlich.
The dynamic behaviour of a single molecule inserted in a self-assembled monolayer matrix at low temperature (2004)

We observed the dynamic behaviour of a single conjugated molecule, 4-biphenylmethanethiol (BPMT), inserted in a self-assembled monolayer (SAM) matrix of a bicyclo[2.2.2]octane derivative (BCO) using scanning tunnelling microscopy at . At room temperature (Wakamatsu et al 2003 Nanotechnology 14 258), stochastic switching of BPNT and lateral movement of the BPMT and the BCO molecules were observed even in the well-ordered BCO SAM matrix on Au(111) terraces. Such movement was, however, rarely observed in the SAM on Au(111) terraces at . Single BPMT molecules were fixed in the well-ordered BCO SAM matrix at , except at step edges and edges of one atom deep pits of the Au(111) substrate. When a disordered BCO SAM matrix was created intentionally by applying voltage pulses, the stochastic switching of the single BPMT molecule and the lateral movement of the BCO and the BPMT molecules were observed more frequently than those at the step edges and the pit edges at .
Fluoroscopy as an imaging means for computer-assisted surgical navigation (1999)

This article shows the feasibility of this technology through its use in cadaver trials to perform the difficult task of distal locking of femoral nails.
Safety assessment of the process Green Loop System, used to recycle polycyclohexylene dimethylene terephthalate glycol‐modified (PCTG) plates for use as food contact materials (2022)

The EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP) assessed the safety of the recycling process Green Loop System (EU register number RECYC174), a closed and controlled product loop. The input consists of washed plates of polycyclohexylene dimethylene terephthalate glycol-modified (PCTG) having been used in, e.g. canteens. The plates are ground, converted to new plates, returned to the users of the loop and used as before recycling. The management system to ensure a closed loop is critical, i.e. compliance of the origin of the input with Commission Regulation (EC) No 282/2008 and full traceability from input to final product should be ensured. The Panel concluded that the input of the process Green Loop System originates from product loops that are in a closed and controlled chain, designed to ensure that only materials and articles that have been intended for food contact are used and that contamination other than by food can be ruled out. The recycling process Green Loop System is, therefore, able to recycle PCTG plates intended for repeated use, for contact with aqueous, acidic and fatty food, at low and high temperatures.
Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system. (1994)

Conditional overexpression of human cyclins B1, D1, and E was accomplished by using a synthetic cDNA expression system based on the Escherichia coli tetracycline repressor. After induction of these cyclins in asynchronous Rat-1 fibroblasts, a decrease in the length of the G1 interval was observed for cyclins D1 and E, consistent with an acceleration of the G1/S phase transition. We observed, in addition, a compensatory lengthening of S phase and G2 so that the mean cell cycle length in populations constitutively expressing these cyclins was unchanged relative to those of their uninduced counterparts. We found that expression of cyclin B1 had no effect on cell cycle dynamics, despite elevated levels of cyclin B-associated histone H1 kinase activity. Induction of cyclins D1 and E also accelerated entry into S phase for synchronized cultures emerging from quiescence. However, whereas cyclin E exerted a greater effect than cyclin D1 in asynchronous cycling cells, cyclin D1 conferred a greater effect upon stimulation from quiescence, suggesting a specific role for cyclin D1 in the G0-to-G1 transition. Overexpression of cyclins did not prevent cells from entering into quiescence upon serum starvation, although a slight delay in attainment of quiescence was observed for cells expressing either cyclin D1 or cyclin E. These results suggest that cyclins D1 and E are rate-limiting activators of the G1-to-S phase transition and that cyclin D1 might play a specialized role in facilitating emergence from quiescence.
Synthesis and Properties of Pyrrolo (1,2-a) quinoxalines (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and Properties of Pyrrolo (1,2-a) quinoxalinesEdward C. Taylor and Gordon W. H. CheesemanCite this: J. Am. Chem. Soc. 1964, 86, 9, 1830–1835Publication Date (Print):May 5, 1964Publication History Published online1 May 2002Published inissue 5 May 1964https://pubs.acs.org/doi/10.1021/ja01063a035https://doi.org/10.1021/ja01063a035research-articleACS PublicationsRequest reuse permissionsArticle Views193Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts