gebhart/patrepeval huggingface dataset:
Balanced Wideband Filtering Planar Inverted-F Antenna Design (2016)

A balanced wideband (WB) planar inverted-F antenna (PIFA) integrated with a balanced WB bandpass filter (BPF) is presented in this letter. Due to circuit symmetry, the balanced patch PIFA does not need a grounded via hole for its shorting strip, rendering the PIFA easy to fabricate. The balanced WB BPF that is added in front of the balanced PIFA serves to improve the differential-mode (DM) passband selectivity and upper stopband rejection and meanwhile to increase the common-mode (CM) rejection. In terms of the passband selectivity defined by the ratio of 20-dB bandwidth to the 3-dB bandwidth in the DM return-loss response, the simulated WB filtering PIFA's selectivity is increased from 0.6 to 0.86 after the WB BPF is integrated. In addition, high CM suppression was observed with a maximum return loss of 2.37 dB within the DM passband.
Regional isolation in the right atrium with disruption of intra‐atrial conduction after catheter ablation of atrial tachycardia (2019)

Complex ablation lesions in patients with prior valve surgery, prior ablation, or atrial myopathy may result in unintended localized conduction block in the RA. In some cases, isolation of the lateral RA can result in complete sinus exit block with profound bradycardia requiring pacemaker implantation.
Formulation Design of a Highly Hygroscopic Drug (Pyridostigmine Bromide) for its Hygroscopic Character Improvement and Investigation of In Vitro/In Vivo Dissolution Properties (2007)

Pyridostigmine bromide (PB) sustained-release (SR) pellets were developed by extrusion-spheronization and fluid-bed methods using Taguchi experimental and 2(3) full factorial design. In vitro studies, the 2(3) full factorial design was utilized to search for the optimal SR pellets with specific release rate at different time intervals (release percent of 2, 6, 12, and 24 hr were 6.24, 33.48, 75.18, and 95.26%, respectively) which followed a zero-order mechanism (n=0.93). The results of moisture absorption by Karl Fischer has shown the optimum SR pellets at 25 degrees C/60% RH, 30 degrees C/65% RH, and 40 degrees C/75% RH chambers from 1 hr-4 weeks, attributing that the moisture absorption was not significantly increased. In the in vivo study, the results of the bioavailability data showed the Tmax (from 0.65+/-0.082 hr-4.82+/-2.12 hr) and AUC0-30 hr (from 734.88+/-230.68 ng/mL.hr-1454.86+/-319.28 ng/mL.hr) were prolonged and increased, as well as Cmax (from 251.87+/-27.51 ng/mL-115.08+/-14.87 ng/mL) was decreased for optimum SR-PB pellets when compared with commercial immediate-release (IR) tablets. Furthermore, a good linear regression relationship (r=0.9943) was observed between the fraction dissolution and fraction absorption for the optimum SR pellets. In this study, the formulation design not only improved the hygroscopic character of PB but also achieved the SR effect.
ELECTRON BEAM IRRADIATION ON NALIDIXIC ACID‐RESISTANT SALMONELLA MONTEVIDEO IN COOKED TOMATO PUREE OF VARIOUS pH VALUES (2010)

ABSTRACT Electron beam (e‐beam) is a technology that uses ionizing radiation to destroy bacteria in a nonthermal manner. D 10 values were obtained for nalidixic acid (NA)‐resistant Salmonella Montevideo in autoclaved Roma tomato puree pH adjusted to pH 3.4, 3.9, 4.4 and 4.9 and subjected to e‐beam at 0 (control), 0.5, 1.0, 1.5, 2.0 and 2.5 kGy. Survivors were enumerated using standard spread‐plating method. NA‐resistant S. Montevideo was not recovered in puree at pH 3.4 or 3.9. Significant reductions ( P &lt; 0.05) were determined at both pH 4.4 and 4.9 between the control (0 kGy) and samples exposed to ≥ 1.5 kGy. D 10 values were 1.07 and 1.50 kGy, respectively, which are greater than previously published D 10 values for other Salmonella strains in various media. Tomato puree has antioxidant potential which may have provided protection against the e‐beam radiation. Radiation resistance as a result of acid adaptation may have also contributed to this effect. PRACTICAL APPLICATIONS Electron beam (e‐beam) irradiation is a nonthermal technology that uses ionizing radiation to destroy bacteria and spoilage microorganisms. Several studies have shown this technique effective for the reduction of bacterial pathogens on fruits and vegetables with no changes in texture, color or sensory quality. Some studies have suggested that the food matrix may influence sensitivity of bacterial strains to irradiation; therefore, the objective of this experiment was to determine the e‐beam radiation dose needed to achieve a one log reduction in population (D 10 value) for nalidixic acid‐resistant Salmonella Montevideo in a tomato puree at low and high pHs.
Nematicidal and allelopathic responses of Lantana camara root extract (2003)

The impact of root leachates of Lantana camara L., a tropical weed, against Meloidogyne javanica, the root-knot nematode, was tested under laboratory and pot conditions. Concentrated and diluted root leachate caused substantial mortality of M. javanica juveniles. Significant suppression of the nematode was achieved when soil was treated with a full-strength concentration of the leachate. Whilst this high concentration retarded plant height and shoot fresh weight, more diluted concentrations actually enhanced plant growth. To establish whether this inhibition of plant growth from the leachate was the result of depleted nitrogen levels in the soil due to the leachate, soil treated with such leachates was given urea as an additional nitrogen source. Urea not only enhanced nematode suppression activity of the root leachates but also increased seedling emergence and growth of mungbean. Application of the L. camara root leachates in combination with Pseudomonas aeruginosa, a plant growth-promoting rhizobacterium, significantly reduced nematode population densities in roots and subsequent root-knot infection, and enhanced plant growth. While a high concentration of root leachate slightly reduced P. aeruginosa colonization in the rhizosphere and inner root tissues, the nematicidal efficacy of the bacterium was unaffected. The root leachate of L. camara was found to contain phenolic compounds, including p-hydroxybenzoic acid, vanillic acid, caffeic acid, ferulic acid and a quercetin glycoside, 7-glucoside. It also contained weak enzymic hydrogen cyanide.
A Minimally Invasive Method for the Treatment of Post-Traumatic Disorders of the Bone Union of the Tibia (2020)

Background . The ability to control regeneration processes is a key link in the development of methods for treating patients with post-traumatic disorders of reparative osteogenesis. Aim of the study. To evaluate the effectiveness of the fusion of the tibia by local application of the interferon-beta preparation with autogenous bone marrow punctate in post-traumatic disorders of reparative regeneration. Material and methods. The analysis of the effectiveness of clinical application of autogenous bone marrow with interferon-beta-1b in 64 patients with delayed consolidation and pseudarthrosis of the tibia was carried out. All patients underwent external bone fixation. In order to optimize reparative osteogenesis during the operation, a mixture containing 3–4 ml of bone marrow with 8 million IU/0.5 ml of interferon beta-1b solution was injected locally into the interfragmental space. Results . With puncture local injection of interferon-beta with punctate of autogenous bone marrow with delayed consolidation, fusion of the tibial fracture was achieved in 100 % of cases. In patients with a diagnosis of a pseudarthrosis of the tibia, a positive result was achieved in 90.3 % of cases. Thus, the local application of autogenous bone marrow together with the interferon-beta preparation made it possible to achieve bone fusion in post-traumatic disorders of bone regeneration in 95.2 % of cases. Conclusion . With delayed consolidation and developing hypertrophic pseudoarthrosis in conditions of stable fixation with anatomical reposition of fragments, puncture autotransplantation of a mixture of bone marrow with a solution of interferon-beta is proposed.
ChemInform Abstract: Enolethers. Part 21. Synthesis of 5,5′‐Disubstituted 4,4′‐ Bipyrimidines. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
FOXD1 promotes nephron progenitor differentiation by repressing decorin in the embryonic kidney (2013)

Forkhead transcription factors are essential for diverse processes in early embryonic development and organogenesis. Foxd1 is required during kidney development and its inactivation results in failure of nephron progenitor cell differentiation. Foxd1 is expressed in interstitial cells adjacent to nephron progenitor cells, suggesting an essential role for the progenitor cell niche in nephrogenesis. To better understand how cortical interstitial cells in general, and FOXD1 in particular, influence the progenitor cell niche, we examined the differentiation states of two progenitor cell subtypes in Foxd1(-/-) tissue. We found that although nephron progenitor cells are retained in a primitive CITED1-expressing compartment, cortical interstitial cells prematurely differentiate. To identify pathways regulated by FOXD1, we screened for target genes by comparison of Foxd1 null and wild-type tissues. We found that the gene encoding the small leucine-rich proteoglycan decorin (DCN) is repressed by FOXD1 in cortical interstitial cells, and we show that compound genetic inactivation of Dcn partially rescues the failure of progenitor cell differentiation in the Foxd1 null. We demonstrate that DCN antagonizes BMP/SMAD signaling, which is required for the transition of CITED1-expressing nephron progenitor cells to a state that is primed for WNT-induced epithelial differentiation. On the basis of these studies, we propose a mechanism for progenitor cell retention in the Foxd1 null in which misexpressed DCN produced by prematurely differentiated interstitial cells accumulates in the extracellular matrix, inhibiting BMP7-mediated transition of nephron progenitor cells to a compartment in which they can respond to epithelial induction signals.
Proceedings of the Communications Network Management Workshop (1987) Held in Syracuse, New York on 30 June-2 July 1987. (1987)

Abstract : This report presents the results of the 1987 Communications Network Management Workshop sponsored by the Rome Air Development Center in cooperation with The Technical Cooperative Program (TTCP) Sub-Group 5. The results were also presented at last STP-5 meeting held in Malvern, UK during the period 13-17 July 1987. Keywords: Communications networks, Network management, Routing, and Voice and Data networking.
<title>Ultrathin image fiber with hemispherical fiber lens for medical use</title> (1997)

The gradient-index rod lenses have been conventionally used as the objective lens of the ultrathin medical fiberscope. In this paper, we propose to apply the new hemispherical fiber lens for the ultrathin fiberscopes. The lens can be fabricated by attaching a silica rod to imagefiber and heating the free end of the rod in arc charge. As the result of our investigation, it has been known that the radius of the hemispherical lens can be controlled by the discharge time. The imagefiber with the hemispherical lens had a diameter of 0.2 mm, 1600 pixels, a working distance of 3 mm and the angle of view of 40 degrees. It has been found by evaluating its image quality that it has the sufficient feature for the practical medical usage. In addition, it has been shown that the end of the imagefiber itself can be transformed to the hemispherical objective lens, and its optical characteristics as a lens can be controlled by changing the elongating length and the preheating condition.
Abstract 555: The Effect Of Dipeptidyl Peptidase 4 Inhibition On Arterial Blood Pressure Is Context Dependent (2014)

Dipeptidyl peptidase 4 (DPP4) inhibitors decrease the metabolism of endogenous glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) agonists, such as GLP-1(7-36)NH 2 , and GLP-1R agonists are antihypertensive. However, DPP4 inhibitors also impair the metabolism of endogenous Y 1 receptor (Y 1 R) agonists, such as neuropeptide Y 1-36 (NPY 1-36 ), and Y 1 R agonists are pro-hypertensive. Consequently, the long-term effect of DPP4 inhibition on blood pressure may be context dependent. To test this, we conducted radiotelemetry studies under highly controlled conditions to quantify the effects of chronic sitagliptin (80 mg/kg/day; DPP4 inhibitor) on blood pressure in spontaneously hypertensive rats (SHR), Wistar-Kyoto rats (WKY) and Zucker Diabetic-Sprague Dawley rats (ZDSD; model of the metabolic syndrome developed by PreClinOmics). In SHR, chronic (3 weeks) administration of sitagliptin significantly increased systolic, mean and diastolic blood pressures by 10.3, 9.2 and 7.9 mmHg, respectively (p&lt;0.01). Sitagliptin also significantly (p&lt;0.01) increased blood pressure in SHR treated with hydralazine (vasodilator; 25 mg/kg/day) or enalapril (ACE inhibitor; 10 mg/kg/day). Co-administration of BIBP3226 (2 mg/kg/day; Y 1 R antagonist) abolished the pro-hypertensive effects of sitagliptin in SHR. In WKY, chronic sitagliptin slightly decreased (p&lt;0.01) systolic, mean and diastolic blood pressures (-1.8, -1.1 and -0.4 mmHg, respectively). In ZDSD, chronic sitagliptin markedly decreased systolic, mean and diastolic blood pressures (-7.7, -5.8, -4.3 mmHg, respectively). In isolated, perfused ZDSD kidneys pretreated with norepinephrine to induce basal tone, NPY 1-36 and GLP-1(7-36)NH 2 exerted little effect on renovascular tone. In contrast, in isolated SHR kidneys, both NPY 1-36 and GLP-1(7-36)NH 2 elicited potent and efficacious vasoconstriction (increased perfusion pressure by 171 and 132 mmHg, respectively). Conclusions: 1) The effects of DPP4 inhibitors on blood pressure are context dependent; 2) The context-dependent effects of DPP4 inhibitors are due in part to differential renovascular responses to its most important substrates (NPY 1-36 and GLP-1(7-36)NH 2 ); 3) Y 1 R antagonists may augment the beneficial effects of DPP4 inhibitors.
Corrigendum: Evaluating Thiourea Architecture for Intramolecular [2+2] Photocycloaddition of 4‐Alkenylcoumarins (2014)

For the Communication by Nandini Vallavoju, Sermadurai Selvakumar, Steffen Jockusch, Manoj Thathamkulam Prabhakaran, Mukund P. Sibi, and Jayaraman Sivaguru, in Issue 13, 2014 (Adv. Synth. Catal.­ 2014, 356, 2763–2768; DOI: 10.1002/adsc.201400677), in Table 2, entries 4–6 on page 2765 are incorrect due to a typesetting error after proof correction; the correct Table 2 is the following: Entry Catalyst Compound Conditions 1 : 2[b] (% ee, 2)[b] 1 none 1b N2/4 h 66 : 34 racemic 2 3a 1b N2/2 h 0 : 100 86 3 3b 1b N2/4 h 36 : 64 28 4 3f 1b N2/4 h 38 : 62 (56)[c] 10 5 O2/4 h 55 : 45 12 6 air/4 h 37 : 63 12 7 3f 1a N2/4 h 68 : 32 0 8 O2/4 h 78 : 22 0 9 air/4 h 71 : 29 0
166Ho-DOTMP Skeletal Targeted Radiotherapy with melphalan and autologous stem cell support for multiple myeloma (2004)

6656 Background: 166Ho-DOTMP is a radiotherapeutic that localizes specifically to the skeleton and can deliver high dose radiation to the bone and marrow for skeletal targeted radiotherapy (STR). Follow-up data from 3 clinical trials of patients with multiple myeloma are presented. Methods: In 2 Phase I/II dose-escalation trials, 82 patients received a dose of 166Ho–DOTMP calculated to deliver 20, 30, or 40 Gy to the red marrow, plus melphalan (mel; 140 or 200 mg/m2) +/- 8 Gy TBI, followed by autologous stem cell transplant (PBSCT). As of 12/1/03, subjects have been followed for at least 38 months. In a separate Phase II dosimetry trial, 12 patients received 2 tracer doses of 166Ho-DOTMP to determine the reproducibility of biodistribution and pharmacokinetics (PK), followed by a 25 Gy therapy dose with continuous bladder irrigation, followed by 200 mg/m2 mel and PBSCT. These patients have been followed for at least 12 months. Results: Up to 2.3 Ci/m2 166Ho-DOTMP was given in the Phase I/II trials. 29/82 (35%) patients achieved complete response (CR) and ORR (CR + PR + SD) was 91% (7 pts not evaluable). Median duration of CR was > 24 months, and the Kaplan-Meyer estimate of 3 year survival was 60% for all 82 patients. Of 10 patients who received 750 mCi/m2 +/-10%, the CR rate was 40% and the 3-year survival was 90%. However, dose-related radiation-induced bladder and kidney toxicity appeared between 3 and 13 months post-therapy at high doses. Currently, 12 months of follow-up from the Phase II dosimetry trial shows no occurrence of hemorrhagic cystitis or elevated creatinine > Grade 2. The dose of 166Ho-DOTMP in this study was 550 to 860 mCi/m2. A CR rate of 17% was seen, and the biodistribution and PK of 166Ho-DOTMP were reproducible. Monitoring for safety and duration of response is ongoing for both trials. Conclusions: Follow-up from the Phase II dosimetry trial confirms that 750 mCi/m2 +/- 10% of 166Ho–DOTMP provides favorable efficacy and safety as part of the conditioning regimen for patients with multiple myeloma undergoing autologous PBSCT. A Phase III, multicenter, randomized trial with 750 mCi/m2 166Ho-DOTMP is planned to begin enrollment in Q1 of 2004. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration NeoRx NeoRx; PPD NeoRx NeoRx NeoRx, Inc.
Dependence of the Brillouin Frequency Shift on Temperature in a Tellurite Glass Fiber and a Bismuth-Oxide Highly-Nonlinear Fiber (2009)

We investigate the temperature-dependences of the Brillouin frequency shift in a tellurite glass fiber and a bismuth-oxide highly-nonlinear fiber using a Brillouin optical correlation-domain reflectometry system for sensing applications. Negative dependences of -1.14 and -0.88 MHz/K are demonstrated, respectively, in contrast to the positive dependence of +1.18 MHz/K in a standard silica fiber.
Anisotropy induced large exchange bias behavior in ball milled Ni–Co–Mn–Sb alloys (2011)

We report the effect of decrease in the grain size on the structural, magnetic and exchange bias (EB) behavior in ball milled Ni50−xCoxMn38Sb12 (x=0 and 5) Heusler alloys. The existence of a wide range of grain sizes in the ball milled samples results in dramatic changes in the structural and magnetic properties. For x=0, a large EB field of 3.2 kOe is observed in the ball milled sample, compared to a value of 245 Oe of the bulk sample. This increase is attributed to the enhanced exchange coupling between the soft and hard magnetic particles.
Electrochemical Behaviors of Adenosine‐5′‐triphosphate on Molecular Wire Modified Carbon Paste Electrode and Its Sensitive Detection (2012)

Abstract A new electrochemical method was proposed for the determination of adenosine‐5′‐triphosphate (ATP) based on the electrooxidation at a molecular wire (MW) modified carbon paste electrode (CPE), which was fabricated with diphenylacetylene (DPA) as the binder. A single well‐defined irreversible oxidation peak of ATP appeared on MW‐CPE with adsorption‐controlled process and enhanced electrochemical response in a pH 3.0 Britton‐Robinson buffer solution, which was due to the presence of high conductive DPA in the electrode. The electrochemical parameters of ATP were calculated with the electron transfer coefficient (α) as 0.54, the electron transfer number ( n ) as 1.9, the apparent heterogeneous electron transfer rate constant ( k s ) as 2.67 × 10 −5 s −1 and the surface coverage (Γ T ) as 4.15 × 10 −10 mol cm −2 . Under the selected conditions the oxidation peak current was proportional to ATP concentration in the range from 1.0 × 10 −7 mol L −1 to 2.0 × 10 −3 mol L −1 with the detection limit as 1.28 × 10 −8 mol L −1 (3σ) by sensitive differential pulse voltammetry. The proposed method showed good selectivity without the interferences of coexisting substances and was successful applied to the ATP injection samples detection.
Three-Dimensional Bending Stress Analysis for Corrugated Fiberboard Sheet. (1994)

In this study, the deformation and the stress due to the bending of corrugated fiberboard sheet were clarified by three-dimensional large deformation elasticity-plasticity analysis using the finite-element method. Further more, the influence of material properties and process conditions on bending stress was examied and the following results were obtained : the residual stress concentration after the springback will be relaxed by the increase in young's modulus of corrugated media ; and the increase of stress σz, due to the bending at end of bottom liner in contacted with the rotating body, will be restrained.
Anti-Idiotypic Antibodies In Cancer Therapy (2018)

The humoral and cellular immune responses to a growing tumor have been studied extensively in cancer patients; however, the immunoregulatory functions of these responses are not well characterized. One can speculate that cancer patients are capable of producing cancer antibodies, but that the antibodies &quot;disappear&quot; from the circulation through binding to anti-idiotypic antibodies. The ultimate aim of Ab2 immunizations is to induce protective immunity against tumors. Since human tumors can only be grown in immunodeficient animals, the possible immu-notherapeutic effects of Ab2 immunizations must ultimately be evaluated directly in patients. G. T. Nepom et al. have produced Ab2 in rabbits to murine MAb against melanoma-associated antigen p97 (Ab,). Mice immunized with the Ab2 demonstrated delayed-type hypersensitivity (DTH) reactions when challenged with melanoma cells expressing 380,000 p97 molecules per cell, but not when challenged with melanoma cells expressing only 2600 such molecules.
MR Compatible device for Active and Passive Foot Movements (2009)

The present paper presents a new MR compatible robotic device able to induce foot dorsiflexion and plantarflexion movements (‘passive’ patient mode), or to set and control for a series of parameters (force, amplitude) when the same movements are performed by the subject (‘active’ patient mode). Recent studies have demonstrated that the foot dorsiflexion is a critical component of the gait cycle; thus, ankle dorsiflexion/plantarflexion has been proposed as part of locomotor rehabilitation protocols, as well as a functional magnetic resonance imaging (fMRI) paradigm for defining brain activity relevant to gait. The principal aim of this work was to develop a robotic device to be used during fMRI testing, in preand post-locomotor therapy evaluations of cerebral activity. The same device can furthermore be used in the rehabilitation of neurological paretic patients, who need to practise foot movements and/or to relearn locomotor schemas. Design criteria and implementation are described, as well as the final prototype. Great concern was given to choice of materials (for MR compatibility) and to anthropometric dimensions (for patient adapting). Furthermore pneumatic circuit and control software are illustrated. Finally preliminary results obtained from a fMRI exam on a healthy subject are pointed up.