gebhart/patrepeval huggingface dataset:
Mapping of the Snuffbox and Cubital Vessels for Percutaneous Arterial Venous Fistula (pAVF) in Dialysis Patients (2013)

Most dialysis patients meet the anatomic requirements for pAVF in the SBRA or PRA. Vessel size is the most common limiting variable followed by distance between vessels.
Exploratory Data Analysis with MATLAB (2004)

Exploratory data analysis (EDA) was conceived at a time when computers were not widely used, and thus computational ability was rather limited. As computational sophistication has increased, EDA has become an even more powerful process for visualizing and summarizing data before making model assumptions to generate hypotheses, encompassing larger a
A solid lithium superionic conductor Li11AlP2S12 with a thio-LISICON analogous structure (2016)

A solid lithium superionic conductor Li11AlP2S12 with a thio-LISICON analogous structure has been synthesized for the first time by sintering at 500 °C (LAlPS500). Such a pure lithium ionic conductor shows a conductivity of 8.02 × 10(-4) S cm(-1) at 25 °C, a low Ea of 25.4 kJ mol(-1), and a wide electrochemical voltage window of higher than 5.0 V (vs. Li(+)/Li). This facilitation of Li ionic conduction suggests the potential application in solid lithium ion batteries.
Structure-activity relationships OF N-methylthiolated beta-lactam antibiotics with c3 substitutions and their selective induction of apoptosis in human cancer cells (2005)

The development of novel anti-cancer drugs that induce apoptosis has long been a focus of drug discovery. Beta-lactam antibiotics have been used for over 60 years to fight bacterial infectious diseases with little or no side effects observed. Recently a new class of N-methylthiolated beta-lactams has been discovered that have potent activity against methicillin resistant Staphylococcus aureas. Most recently, we determined the potential effects of these N-thiolated beta-lactams on tumorigenic cell growth and found that they are apoptosis-inducers in human cancer cell lines. In the current study, we further determined the effects of the substitution of the O-methyl moiety on C3 and stereochemistry of the beta-lactams on the anti-proliferative and apoptosis-inducing abilities. We have found that lactam 18, in which C3 is substituted with an acrylate ester group, is a very effective proliferation inhibitor against human premalignant and malignant breast, leukemic, and simian virus 40-transformed fibroblast cells. Generally speaking, increasing the size of the moiety on C3 decreases its anti-proliferation potency, possibly indicating steric hindrance with the cellular target or decreased permeability through the cell membrane. We also found that the stereochemistry of the beta-lactams plays an important role in their potency. The 3S,4R isomers are more effective than their enantiomers (3R,4S), suggesting that 3S,4R configuration is more favorable for target interaction.
Androgen receptor binding sites are highly mutated in prostate cancer (2019)

Searchable abstracts of presentations at key conferences in oncology ISSN 2631-4657 (online)
Total vascular exclusion of the liver for the resection of lesions in contact with the vena cava or the hepatic veins (1998)

TVE facilitates resection of critically located hepatic lesions with safety and minimal blood loss. Within the limits of 1 h, prolonged TVE does not increase morbidity.
Expression and Regulation of the Proenkephalin Gene in Rat Sertoli Cells (1989)

Previous studies have shown that multiple forms of proenkephalin RNA are present in the rat and mouse testis that are cell type specific: a 1700-nucleotide transcript, unique to the testis, found in spermatogenic cells, and a 1450-nucleotide form of somatic cell origin. In the present studies, rat Sertoli cells are shown to contain the 1450-nucleotide form of proenkephalin RNA. The concentration of this transcript is quite low immediately after Sertoli cell isolation, but increases after 1 day in culture to a constant level. Proenkephalin RNA levels are stimulated severalfold by FSH and cAMP, but are not significantly affected by LH or testosterone. These studies demonstrate that Sertoli cells are at least one source of the somatic, 1450-nucleotide form of proenkephalin RNA in the rat testis. The expression of opioid peptide genes by Sertoli cells as well as by germ and Leydig cells is further evidence for the postulated autocrine or paracrine functions of these peptides in the testis.
Non‐expression of HLA‐A*2901102 N is caused by a nucleotide exchange in the mRNA splicing site at the beginning of intron 4 (2002)

We describe the identification of the novel human leukocyte antigen (HLA) blank allele A*2901102 N which was detected in an individual of mixed race. The serological HLA class I typing was A1; B7,44 whereas PCR-SSP indicated the presence of an additional A*29 allele. The pedigree analysis demonstrated that the new blank allele segregated with the haplotype A*29null B*07, inherited from the individual's Vietnamese father. A single G-->Tau transversion was detected at position 1 of intron 4, which is a highly conserved nucleotide position in vertebrate splice donor sites. Accordingly, it is very likely that this nucleotide exchange inhibits the splicing of intron 4, resulting in a premature stop codon further downstream. Despite this alteration, transcription into mRNA was demonstrated.
Impact of brain overgrowth on sensorial learning processing during the first year of life (2022)

Macrocephaly is present in about 2-5% of the general population. It can be found as an isolated benign trait or as part of a syndromic condition. Brain overgrowth has been associated with neurodevelopmental disorders such as autism during the first year of life, however, evidence remains inconclusive. Furthermore, most of the studies have involved pathological or high-risk populations, but little is known about the effects of brain overgrowth on neurodevelopment in otherwise neurotypical infants. We investigated the impact of brain overgrowth on basic perceptual learning processes (repetition effects and change detection response) during the first year of life. We recorded high density electroencephalograms (EEG) in 116 full-term healthy infants aged between 3 and 11 months, 35 macrocephalic (14 girls) and 81 normocephalic (39 girls) classified according to the WHO head circumference norms. We used an adapted oddball paradigm, time-frequency analyses, and auditory event-related brain potentials (ERPs) to investigate differences between groups. We show that brain overgrowth has a significant impact on repetition effects and change detection response in the 10-20 Hz frequency band, and in N450 latency, suggesting that these correlates of sensorial learning processes are sensitive to brain overgrowth during the first year of life.
Anisotropic Composite Materials with Intensity-Dependent Permittivity Tensor: The Bruggeman Approach (2001)

The Bruggeman approach is implemented to homogenize a collection of identical, similarly oriented, electrically small, ellipsoidal particles with intensity-dependent refractive index that are dispersed randomly and homogeneously in an isotropic, linear, dielectric host material. The homogenized composite medium is assumed to be cubically nonlinear and anisotropic, in the simplest approximation. The anisotropy of nonlinearity may be considerably different from the anisotropy of the linearity. The possible enhancement of nonlinearity is also anisotropic, with the most desirable performance along the shortest principal axis of the ellipsoidal particles.
Trehalose levels and survival ratio of freeze-tolerant versus freeze-sensitive yeasts (1990)

Five freeze-tolerant yeast strains suitable for frozen dough were compared with ordinary commercial bakers' yeast. Kluyveromyces thermotolerans FRI 501 cells showed high survival ability after freezing when their resting cells were fermented for 0 to 180 min in modified liquid medium, and they grew to log and stationary phases. Among the freeze-tolerant strains of Saccharomyces cerevisiae, FRI 413 and FRI 869 showed higher surviving and trehalose-accumulating abilities than other S. cerevisiae strains, but were affected by a prolonged prefermentation period and by growth phases. The freeze tolerance of the yeasts was, to some extent, associated with the basal amount of intracellular trehalose after rapid degradation at the onset of the prefermentation period. In the freeze-sensitive yeasts, the degree of hydrolysis of trehalose may thus be affected by the kind of saccharide, unlike in freeze-tolerant yeasts.
Imaging technological study on radiographic structure of the bone trabeculae. (1987)

ヒト大腿骨ブロックを酸処理により脱灰し, また, X線撮影時のX線入射角度を変化させた。そして, 経時的に規格X線撮影を行い, 細かい骨梁, 粗な骨梁および網目状の3種類の骨梁コントラストおよびパターンの変化を起こした。そして, これらの骨梁変化を物理的評価法であるRMS評価法と視覚的評価法である検出能評価法を用いて解析し, 骨梁変化の有無の認識能について比較した。また, Dental film (: Film) とDental Xeroradiography (: Xero.) の骨梁描出能の差異についても検討を行った。その結果は, 視覚評価では骨梁の種類に関係なく骨梁変化の認識が容易であり, 検出能はFilmがXero. に比べて高い傾向を示した。一方, RMS評価では, 細かい骨梁の変化の認識が困難であり, FilmとXero. では, その変動に相違が認められた。骨梁のパターン変化においては, 検出能は, コントラストの変化に比べて低く, Xero. はFilmに比べて, 細かい骨梁において検出能が高い傾向を示した。一方, RMS評価では, 網目状の骨梁変化の認識が困難であり, 粗な骨梁において, FilmとXero. の変動に相違が認められた。次に犬の抜歯窩治癒過程における骨梁の新生状態を, 同一の評価法で解析した。評価は, 骨梁の粒状すなわち粗密度の変化の認識能について比較検討した。その結果, RMS評価法は, 骨梁の粗密の変化を, Film, Xero, 共に正確に再現した。これに対して, 検出能評価法では, Xero. がFilmに比べて骨梁の粗密の変化の認識が容易である事が解った。
Diagnostic accuracy and limit of detection of ten malaria parasite lactate dehydrogenase-based rapid tests for Plasmodium knowlesi and P. falciparum (2022)

Selected RDTs demonstrate sufficient performance for detection of major human malaria species including <i>P. knowlesi</i> in co-endemic areas where microscopy is not available, particularly for higher parasite counts, although cannot reliably differentiate among <i>non-falciparum</i> malaria.
Positron lifetime measurements on neutron-irradiated InP crystals (1996)

Neutron-irradiated InP single crystals have been investigated by positron-lifetime measurements. The samples were irradiated with thermal neutrons at different fluences yielding concentrations for Sn-transmuted atoms between 2×1015 and 2×1018 cm−3. The lifetime spectra have been analyzed into one exponential decay component. The mean lifetimes show a monotonous increase with the irradiation dose from 246 to 282 ps. The increase in the lifetime has been associated to a defect containing an Indium vacancy. Thermal annealing at 550 °C reduces the lifetime until values closed to those obtained for the as-grown and conventionally doped InP crystals.
Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients (2006)

Our data supports a mechanism whereby reduced ATP production in demyelinated segments of upper motor neuron axons impacts ion homeostasis, induces Ca2+-mediated axonal degeneration, and contributes to progressive neurological disability in MS patients.
Orbital Stark effect and quantum confinement transition of donors in silicon (2009)

Adiabatic shuttling of single impurity bound electrons to gate-induced surface states in semiconductors has attracted much attention in recent times, mostly in the context of solid-state quantum computer architecture. A recent transport spectroscopy experiment for the first time was able to probe the Stark shifted spectrum of a single donor in silicon buried close to a gate. Here, we present the full theoretical model involving large-scale quantum mechanical simulations that was used to compute the Stark shifted donor states in order to interpret the experimental data. Use of atomistic tight-binding technique on a domain of over a million atoms helped not only to incorporate the full band structure of the host, but also to treat realistic device geometries and donor models, and to use a large enough basis set to capture any number of donor states. The method yields a quantitative description of the symmetry transition that the donor electron undergoes from a three-dimensional Coulomb confined state to a two-dimensional (2D) surface state as the electric field is ramped up adiabatically. In the intermediate field regime, the electron resides in a superposition between the atomic donor states and the 2D surface states. In addition to determining the effect of field and donor depth on the electronic structure, the model also provides a basis to distinguish between a phosphorus and an arsenic donor based on their Stark signature. The method also captures valley-orbit splitting in both the donor well and the interface well, a quantity critical to silicon qubits. The work concludes with a detailed analysis of the effects of screening on the donor spectrum.
Efficiency of Metasurface Antennas (2017)

Different types of efficiencies are introduced for metasurface (MTS) antennas based on single point-source excitation: 1) the feed efficiency ε <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">feed</sub> is the power delivered by the feed to surface wave (SW) over the input power; 2) the tapering efficiency ε <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">tap</sub> quantifies the deviation with respect to a uniform illumination; 3) the conversion efficiency ε <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">conv</sub> defines the capability of the MTS to transform the SW power into leaky-wave power; and 4) the ohmic efficiency ε <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Ω</sub> accounts for the antenna losses. The product of all of these factors provides the overall efficiency of the antenna. New, quite general analytical formulas are suggested to estimate any individual efficiency. In particular, it is seen that ε <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">feed</sub> can reach also 90% by using planar or quasiplanar circularly symmetric sources. It is also proven that the product ε <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">conv</sub> ε <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">tap</sub> cannot be larger than 58% for a uniform modulation; however, by using a nonuniform modulation, it can be increased to reach ε <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">conv</sub> ε <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">tap</sub> ≈ a/λ/(a/λ + 2), where a/λ is the antenna radius in free-space wavelengths. A new closedform formula for estimating the losses is given. In accordance with the prescription given here, one can reach 75% of global efficiency, including losses, until a radius of 20 wavelengths with commercially available substrates.
Laser Analytical Probing of Ultra-Short-Laser-Matter Interaction: Ejected Particles And Surface Topography (2009)

Ultra fast laser interaction with surfaces results in fast electronic and thermal ablation processes. The way, how the energy is deposited, determines to a large extent, how efficiently the different processes contribute to laser‐matter interaction. It will be shown, how laser analytical techniques can help to identify the time behavior of the energy deposition, the composition and energy of the emitted particles. Atomic Force Microscopy (AFM) allows determining the surface topography after different stages of ultra‐short laser‐matter interaction. Both techniques combined can yield substantial information for better understanding the physics involved. The appearance of so‐called nano‐hillocks on the surface can be regarded as a typical topographic feature associated with fast electronic processes (correlated with the existence of hot electrons), in particular, demonstrating the efficient localization of energy in small volumes.
Rhodamine Spiroamides for Multicolor Single‐Molecule Switching Fluorescent Nanoscopy (2009)

The design, synthesis, and evaluation of new rhodamine spiroamides are described. These molecules have applications in optical nanoscopy based on random switching of the fluorescent single molecules. The new markers may be used in (co)localization studies of various objects and their (mutual) positions and shape can be determined with a precision of a few tens of nanometers. Multicolor staining, good photoactivation, a large number of emitted photons, and selective chemical binding with amino or thiol groups were achieved due to the presence of various functional groups on the rhodamine spiroamides. Rigidized sulfonated xanthene fragment fused with six-membered rings, N,N'-bis(2,2,2-trifluoroethyl) groups, and a combination of additional double bonds and sulfonic acid groups with simple aliphatic spiroamide residue provide multicolor properties and improve performance of the rhodamine spiroamides in photoactivation and bioconjugation reactions. Having both essential parts of the photoswitchable assembly-the switching and the fluorescent (reporter) groups-combined in one chemical entity make this approach attractive for further development. A series of rhodamine spiroamides is presented along with characterizations of their most relevant properties for application as fluorescent probes in single-molecule switching and localization microscopy. Optical images with resolutions on the nanometer scale illustrate the potential of the labels in the colocalization of biological objects and the two-photon activation technique with optical sectioning.
The Rapid Evaluation of Potential Fields in Particle Systems (1988)

The Rapid Evaluation of Potential Fields in Particle Systems presents a group of algorithms for the computation of the potential and force fields in large-scale systems of particles that are likely to revolutionize a whole class of computer applications in science and engineering. In many areas of scientific computing, from studying the evolution of galaxies, to simulating the behavior of plasmas and fluids, to modelling chemical systems, a numerical scheme is used to follow the trajectories of a collection of particles moving in accordance with Newton's second law of motion in a field generated by the whole ensemble. Extending the earlier work of Rokhlin, Greengard has developed general, numerically stable methods for evaluating all pairwise interactions in linear time, a great improvement over the quadratic time required by the naive approach, and significantly better than any other proposed alternative. The "Rokhlin-Greengard" algorithm promises to make previously prohibitive simulations feasible, with speedups of three to four orders of magnitude in a system of a million particles. Moreover, the algorithm is well-suited for vector and parallel machines, and should make full use of their capabilities. The author presents his work with great clarity, and demonstrates the superiority of his methods both by mathematical analysis and by the results of numerical experiments. The Rapid Evaluation of Potential Fields in Particle Systems is a 1987 ACM Distinguished Dissertation.
54 Haemodynamic and renal response to losartan during salt depletion or salt repletion (1993)

Doig, J. K.; McFadyen, Robert; Sweet, Charles S.; Devlin, Alison M.; Reid, John L. Author Information
Narcissus Alkaloids, XV. Roserine from Narcissus pallidulus (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNarcissus Alkaloids, XV. Roserine from Narcissus pallidulusJaume Bastida, Carles Codina, Francesc Viladomat, Mario Rubiralta, Jean-Charles Quirion, and Bernard WenigerCite this: J. Nat. Prod. 1992, 55, 1, 134–136Publication Date (Print):January 1, 1992Publication History Published online1 July 2004Published inissue 1 January 1992https://pubs.acs.org/doi/10.1021/np50079a020https://doi.org/10.1021/np50079a020research-articleACS PublicationsRequest reuse permissionsArticle Views91Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Assessing the Fit of the Logistic Regression Model to Individual Matched Sets of Case-Control Data (1996)

We develop exact conditional methods for checking the fit of a logistic regression model to individual matched sets in case-control studies. Justifications are given for preferring this approach to conventional maximum likelihood-based methods. Data from two studies are used to illustrate the techniques.
PMO-239 Inflammatory bowel disease and pregnancy: lack of knowledge is associated with negative patient views (2012)

Introduction Enabling women with inflammatory bowel diseases (IBD) to a have successful pregnancy requires complex decisions. This study aimed to assess patients' views on IBD and pregnancy and to correlate them with knowledge. Methods Female IBD patients aged 18–45 years were recruited from Australian gastroenterology clinics and private offices. Data were collected on demographics, disease specifics and previous pregnancies. General attitudes were assessed on fertility, medication use, mode of delivery and pregnancy outcomes. Attitudes regarding their personal situation were assessed in participants who had not given birth since their diagnosis of IBD. Agreement was rated on 5 Point Likert scales and knowledge of pregnancy related issues in IBD was assessed by the recently validated Crohn's and Colitis Pregnancy Knowledge Score “CCPKnow”. Statistical analysis was performed using Student t test and ANOVA. Results Of 145 women (median age 32 years, 70% married) 45% had Crohn's disease, 45% ulcerative colitis and 10% IBD-unclassified. 49 women had successfully delivered children after their diagnosis of IBD. General attitudes : Only 51% agreed that IBD medication should be continued prior to conception. 68% agreed with the need for medical therapy for flares during pregnancy, but 24% felt it more important to tolerate symptoms rather than to have medicines. 36% of participants believed that any IBD medication is “bad” for unborn children. Patients believed that women with IBD are likely to have a vaginal delivery (87%) or a healthy baby (68%), but 37% expected a difficult pregnancy. 70% thought that women on IBD medication should not breastfeed. Personal attitudes : Of 96 nulliparous women after IBD diagnosis, 46% were worried about infertility, passing IBD to offspring (75%) and 30% considered not having children because of IBD. 90% worried about the effect of IBD on pregnancy and 91% about the effects of pregnancy on IBD. Correlation of attitudes and knowledge : General attitudes that “medication should be stopped prior to conception” (p&lt;0.001), “pregnant women should avoid all IBD drugs” (p&lt;0.001), and “put up with symptoms” (p&lt;0.001) were all associated with significantly lower knowledge. Personal attitudes were not associated with knowledge. Conclusion A significant minority of women felt that IBD medication is harmful to unborn children and women should put up with symptoms. Fear of infertility and concerns about inheritance may explain the extremely high rate of women considering not having children because of IBD. Views contrary to medical evidence were associated with significantly lower knowledge; education and personal counselling should be offered to young women with IBD, particularly those with a low CCPKnow score. Competing interests None declared.