gebhart/patrepeval huggingface dataset:
Design of high-magnetic field gradient sources for controlling magnetically induced flow of ferrofluids in microfluidic systems (2003)

The use of miniature electromagnets for ferrofluid-actuated liquid dispensing into microfluidic channels has been investigated by numerical simulations using the finite element method and measurements of fluid displacement and flow rate. The simulations illustrate the effect of structural and geometrical parameters of single and paired solenoid coils on the magnetic force experienced by the ferrofluid. Dual solenoids were used for extended fluid displacement. Ferrofluid positioning and flow rates were controlled also by using a solenoid with an iron core. The experimental measurements of fluid flow in capillaries were used to validate the modeling calculations. The results can be used as a basis for the development of on-chip ferrofluid-based devices integrated with microfluidic architectures.
Coreference Resolution with ILP-based Weighted Abduction (2012)

This paper presents the first systematic study of the coreference resolution problem in a general inference-based discourse processing framework. Employing the mode of inference called weighted abduction, we propose a novel solution to the overmerging problem inherent to inference-based frameworks. The overmerging problem consists in erroneously assuming distinct entities to be identical. In discourse processing, overmerging causes establishing wrong coreference links. In order to approach this problem, we extend Hobbs et al. (1993)’s weighted abduction by introducing weighted unification and show how to learn the unification weights by applying machine learning techniques. For making large-scale processing and parameter learning in an abductive logic framework feasible, we employ a new efficient implementation of weighted abduction based on Integer Linear Programming. We then propose several linguistically motivated features for blocking incorrect unifications and employ different large-scale world knowledge resources for establishing unification via inference. We provide a large-scale evaluation on the CoNLL-2011 shared task dataset, showing that all features and almost all knowledge components improve the performance of our system.
Induction of differentiation in U‐937 and NB4 cells is associated with inhibition of tissue factor production (1999)

Tissue factor (TF) production is under strict control in mature monocytic cells. However, constitutive expression of TF can be found in myelomonocytic cells and in haematopoietic cells arrested at an early stage of differentiation. In this paper we show that TF expression is down-regulated during the monocyte/granulocyte differentiation process, using the human monoblastic U-937 and the acute promyelocytic leukaemia NB4 cell lines as models. Expression of TF mRNA, protein and procoagulant activity (PCA) was constitutively high in untreated cells. Exposure of U-937 cells to 1alpha,25-dihydroxycholecalciferol (VitD3) and all-trans retinoic acid (ATRA) resulted in down-regulation of TF expression and PCA. In NB4 cells induction by ATRA, but not VitD3, resulted in the down-regulation of TF expression and PCA. Consistent with this, induction of terminal differentiation, as confirmed by the expression of differentiation associated antigens and cell cycle arrest, was inversely correlated to TF expression in U-937 and NB4 cells. Moreover, terminally differentiated U-937 cells retained the capacity to respond to inflammatory mediators, i.e. lipopolysaccharide and interferon-gamma, by a rapid increase in TF expression. In conclusion, we show that not only ATRA but also VitD3 is a potent suppressor of monocytic TF expression and thus might have potential clinical use for the treatment of coagulopathies.
Large-T-antigen-p53 complex formation is not cold sensitive in a cold-sensitive transformant induced by simian virus 40 mutant tsA1499 (1984)

F111 rat cells transformed by simian virus 40 mutant tsA1499 are cold sensitive for the expression of transformation. Yet, unlike F111 cells transformed by tsA58, they do not lose the ability to stabilize the transformation-associated host cell protein p53 at the temperature at which transformation is extinguished.
Synthetic polymeric membrane with pyridine moiety for gas separation. (1986)

塩基性固定キャリヤーとしでピリジン環を側鎖に有するコポリ (4-ビニルピリジンーアクリロニトリル) 膜によるCO2, O2, N2の透過ならびに収着挙動を検討した. その結果, CO2の膜透過現象は, 二元収着輸送理論によって説明された. 一方, O2ならびにN2はHenry型溶解によって膜内に溶解し拡散する, いわゆる単純透過によって脱明された. 本膜では, CO2がO2やN2と異なり選択的に透過され, と9わけCO2濃度の低い混合気体からのCO2の分離において有効であることが明らかになった.
Abstract 18960: Anti-PCSK9 VLP Immunization Reduces Cholesterol Levels in Mice and Non-human Primates (2014)

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secretory protease involved in cholesterol homeostasis by enhancing endosomal and lysosomal degradation of cell surface low-density lipoprotein receptors (LDL-R). While increased activity of PCSK9 has been associated with hypercholesterolemia and atherosclerosis, several healthy patients have also been identified with loss-of-function PCSK9 mutations and exhibit a hypocholesterolemia phenotype (and an extremely low incidence of coronary artery disease - CAD). These observations indicate that PCSK9 is an attractive target for the purpose of lowering circulating LDL-cholesterol, and therefore decreasing the potential for CAD and atherosclerosis. To date, several different strategies are being attempted to target and reduce plasma levels of PCSK9 but they are based on expensive therapies that may be utilized only by a limited number of patients. Phase 2 clinical studies utilizing monoclonal antibodies targeting PCSK9 demonstrated a reduction in LDL-c up to 70%. To reach a much broader population and design a low cost, long-term treatment, we developed a Virus-like Particle (VLP) based vaccine that targets the LDLR binding domain of PCSK9.

Immunized mice (n=20) developed high-titer anti-peptide IgG responses that cross-reacted with PCSK9. Total cholesterol, free cholesterol, phospholipid and triglyceride levels were measured after the final boost. Vaccination with PCSK9-VLPs significantly reduced all four of these measures, with total cholesterol decreasing by over 30% (relative to pre-vaccination levels). We also immunized small groups (n=3) of rhesus macaques. Vaccination resulted in changes in lipoprotein profile at week 2, and decreases in TC (14.2%), ApoB (13.4%) and LDL-p (28.4%) at week 6 were observed. The PCSK9-VLP vaccine was well tolerated with no signs of overt toxicity in both species. In conclusion, these findings suggest that VLP-PCSK9 immunization may be an accessible, low cost, and effective new therapy for hypercholesterolemia and CAD.
Identification of simultaneously active partial discharge sources using combined radio frequency and IEC60270 measurement (2011)

Using a newly developed measurement system, partial discharge (PD) activity has been recorded simultaneously on a pulse-by-pulse basis in terms of radiated radio frequency (RF) energy and the conducted apparent charge measured according to the IEC60270 standard. Two epoxy resin insulation samples containing voids have been activated separately and in parallel and the resulting PD was measured using the combined system. It has been shown that the combined measurement system has the ability to distinguish between discharges occurring simultaneously in each of the respective samples. This is evident in the appearance of separate clusters when the energy of the radio frequency discharge signal is plotted against the apparent charge for a large number of pulses. The identity of the defect producing each cluster has been confirmed by modelling the complete response of a gas-insulated-switchgear chamber to simulated Gaussian current pulses of known charge. The combined technique has also shown potential to distinguish between additional simultaneously active defects, including free metallic particles in oil. The combination of the two measurement systems may enable the classification of PD activity with a greater degree of confidence than conventional phase-resolved measurements allow when more than one defect is present.
Friction Induced Paint Damage: The Role of Coating Attributes (1996)

&lt;div class="htmlview paragraph"&gt;The recent inclusion of painted plastic fascias/bumpers into automotive applications has necessitated the evaluation of potential in-service damagability. One failure mode that has been identified, that of friction-induced paint/substrate damage, has been simulated in a laboratory environment. Our goal was to evaluate the effects of coating attributes, both thermal and mechanical, on subsequent performance of painted thermoplastic olefin (TPO) materials. It was determined that the most significant parameters in the paint which contributed to damage were the glass transition temperature, the secant modulus at break, and the static coefficient of friction. This paper will discuss techniques and results used to reach these findings.&lt;/div&gt;
intersex, a gene required for female sexual development inDrosophila, is expressed in both sexes and functions together withdoublesexto regulate terminal differentiation (2002)

Previous genetic studies indicated intersex (ix) functions only in females and that it acts near the end of the sex determination hierarchy to control somatic sexual differentiation in Drosophila melanogaster. We have cloned ix and characterized its function genetically, molecularly and biochemically. The ix pre-mRNA is not spliced, and ix mRNA is produced in both sexes. The ix gene encodes a 188 amino acid protein, which has a sequence similar to mammalian proteins thought to function as transcriptional activators, and a Caenorhabditis elegans protein that is thought to function as a transcription factor. Bringing together the facts that (1) the ix phenotype is female-specific and (2) functions at the end of the sex determination hierarchy, yet (3) is expressed sex non-specifically and appears likely to encode a transcription factor with no known DNA-binding domain, leads to the inference that ix may require the female-specific protein product of the doublesex (dsx) gene in order to function. Consistent with this inference, we find that for all sexually dimorphic cuticular structures examined, ix and dsx are dependent on each other to promote female differentiation. This dependent relationship also holds for the only known direct target of dsx, the Yolk protein (Yp) genes. Using yeast 2-hybrid assay, immunoprecipitation of recombinant tagged IX and DSX proteins from Drosophila S2 cell extracts, and gel shifts with the tagged IX and DSX(F) proteins, we demonstrate that IX interacts with DSX(F), but not DSX(M). Taken together, the above findings strongly suggest that IX and DSX(F) function in a complex, in which IX acts as a transcriptional co-factor for the DNA-binding DSX(F).
Measurement of low-resistance points on the skin by dry roller electrodes (1988)

Dry skin resistance is measured by application of a positive direct current flowing from a dry electrode to the skin. A device for finding low-resistance points is proposed, and methods for measuring the distribution of skin resistance are discussed. The voltage ratio is used to find the low-resistance points, using both a constant-current and a constant-voltage method. The latter is shown to be particularly effective. Guidelines for optimal design of the device are proposed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Intelligent Nodes in Distribution Systems - Optimizing Steady State Settings (2007)

Due to gradually increasing loads, medium voltage distribution feeders come closer to their voltage and current limits. Furthermore the introduction of distributed generation (DG) causes larger voltage variations. In this paper a control concept is proposed for so called intelligent nodes (INs) applied at medium voltage level. The IN has the potential to extend the power limits of feeders and to improve voltage performance. The IN controls power flow in the distribution grid in order to reduce the difference between minimum and maximum occurring voltages in the distribution grid. In this paper the control concept, which is based on the gradient method, is presented and illustrated with a study grid. Finally a comparison is made with the meshed operation of the study grid.
Human body IoT systems based on the triboelectrification effect: energy harvesting, sensing, interfacing and communication (2022)

Human body IoT systems based on the triboelectrification effect for energy harvesting, sensing, and interaction via wireless communication.
microRNA-132 inhibits the proliferation, migration, and invasion of ovarian cancer cells by regulating CT10 oncogenic gene homolog II-related signaling pathways (2020)

miR-132 inhibits the proliferation, invasion, and migration abilities of ovarian cancer cells through targeting CRKII.
Absolute rate constants for hydrocarbon oxidation. VIII. The reactions of cumylperoxy radicals (1968)

Absolute rate constants have been measured for the reactions of cumylperoxy radicals with a number of hydrocarbons. The cumylperoxy radicals were produced from cumene hydroperoxide. Sufficient hydroperoxide was present to ensure that only cumylperoxy radicals were involved in the rate-determining propagation reaction.Primary and secondary deuterium isotope effects have been measured for propagation and termination in the oxidation of cumene. The rate of hydrogen atom abstraction from ring-substituted cumenes by cumylperoxy radicals can be correlated by the Hammett equation using σ + substituent constants, ρ = −0.29. Primary and secondary peroxy radicals are about 3–5 times more reactive in hydrogen abstraction than tertiary peroxy radicals.
Cytotoxic Alkaloids fromBoehmeria siamensis (2003)

Two new phenanthroquinolizidine alkaloids, boehmeriasins A and B, were isolated from the aqueous ethanolic extract of Boehmeria siamensis Craib (Urticaceae) by bioassay-guided fractionation. Their structures were elucidated on the basis of spectral evidence. Boehmeriasin A possesses cytotoxic activity against 12 cell lines from 6 panels of cancer including lung cancer, colon cancer, breast cancer, prostate cancer, kidney cancer and leukemia with GI (50) between 0.2 and 100 ng/mL, whereas boehmeriasin B showed lower activity.
Transcriptome of Male Breast Cancer Matched with Germline Profiling Reveals Novel Molecular Subtypes with Possible Clinical Relevance (2021)

Male breast cancer (MBC) is a rare and understudied disease compared with female BC. About 15% of MBCs are associated with germline mutation in BC susceptibility genes, mainly <i>BRCA1/2</i> and <i>PALB2</i>. Hereditary MBCs are likely to represent a subgroup of tumors with a peculiar phenotype. Here, we performed a whole transcriptome analysis of MBCs characterized for germline mutations in the most relevant BC susceptibility genes in order to identify molecular subtypes with clinical relevance. A series of 63 MBCs, including 16 <i>BRCA2,</i> 6 <i>BRCA1</i>, 2 <i>PALB2</i>, 1 <i>RAD50</i>, and 1 <i>RAD51D</i> germline-mutated cases, was analyzed by RNA-sequencing. Differential expression and hierarchical clustering analyses were performed. Module signatures associated with central biological processes involved in breast cancer pathogenesis were also examined. Different transcriptome profiles for genes mainly involved in the cell cycle, DNA damage, and DNA repair pathways emerged between MBCs with and without germline mutations. Unsupervised clustering analysis revealed two distinct subgroups, one of which was characterized by a higher expression of immune response genes, high scores of gene-expression signatures suggestive of aggressive behavior, and worse overall survival. Our results suggest that transcriptome matched with germline profiling may be a valuable approach for the identification and characterization of MBC subtypes with possible relevance in the clinical setting.
Congenital tracheal atresia in newborn: case report and review of the literature. (2009)

Tracheal atresia is an uncommon congenital malformation with a high mortality rate. Clinical symptoms occur suddenly after birth. The diagnosis is suspected in any infant in whom improved ventilation is obtained despite aggressive attempts at resuscitation. We describe a small gestational week 34 male newborn affected by tracheal atresia without esophageal fistula with associated fetal growth restriction, ascites and polyhydramnios. Post mortem examination revealed a diffuse cyanotic status, abdominal ascites and a low birth weight. A 3 cm tract of trachea was documented that distantly ended in a blind pouch and without tracheoesophageal fistulae and enlarged bulky lungs connected to each other by a common thin-walled bronchus. Histological examination showed a normal conformed larynx and scratchily cartilaginous disks in the proximal tract of the short trachea. Vascular space referred to small arteries and veins, thin bands of fibrous tissue and adipose tissue were detected under the blind pouch. Lung distal airspaces were lined by premature cubic epithelium separated by a broad poorly vascularized interstitium. A striking interstitial and alveolar edema was remarkable.
Parent-of-origin effects in multiple endocrine neoplasia type 2B. (1994)

Multiple endocrine neoplasia type 2B (MEN 2B) is characterized by medullary thyroid carcinoma, pheochromocytomas, mucosal neuromas, ganglioneuromas, and skeletal and ophthalmic abnormalities. It is observed as both inherited and sporadic disease, with an estimated 50% of cases arising de novo. A single point mutation in the catalytic core region of the receptor tyrosine kinase, RET, has been observed in germ-line DNA of MEN 2B patients. We have analyzed 25 cases of de novo disease in order to determine the parental origin of the mutated RET allele. In all cases the new mutation was of paternal origin. We observe a distortion of the sex ratio in both de novo MEN 2B patients and the affected offspring of MEN 2B transmitting males. These results suggests a differential susceptibility of RET to mutation in paternally and maternally derived DNA and a possible role for imprinting of RET during development.
Osteoneogenesis and Its Influencing Factors During Treatment With the Ilizarov Method (1996)

The radiographs of 57 patients who had undergone 58 callus distractions and 13 epiphyseal distractions were evaluated. During the course of treatment, the density of the distraction areas on radiographs was measured in total and along the medial, lateral, ventral, and dorsal margins using a digital radiograph processing system. The densities of the whole distraction length were correlated to the following parameters: age of patient, start of distraction after corticotomy, mean distraction speed, mean amount of weight load during the period of distraction and consolidation, location of corticotomy (distal femoral metaphysis versus the proximal tibial one), and diclofenac medication. Except for the location of corticotomy and the diclofenac medication, the density was influenced by all these parameters. Age of the patient and weight load were the most important parameters. Patients with leg shortening caused by poliomyelitis and a patient with a shortened leg after amniotic strangulation showed a slower rise of the density trend curve on radiographs than the other patients. When comparing the different regional density curves, a significant gradual density decrease could be observed from the medial to the lateral side in the femur, from lateral to medial in the tibia, and from the dorsal to the ventral side in both bones. The respective differences between lateral and medial density, and between dorsal and ventral density, were significantly higher in cases of callus distraction than in cases in which epiphyseal distraction had been used. The amount of bone regeneration varied regionally primarily because of the inhomogeneous soft tissue covering of the bone and the impairment of its local blood supply by the surgical exposure for the corticotomy. The clinical relevancy of the various parameters for osteoneogenesis is discussed in this article.
Edwardsiella septicaemias. (2011)

In this chapter, the biology, current classification, diagnosis, genetic characteristics, geographical distribution, host range, epidemiology, transmission, control, treatment, economic, environmental and social importance of Edwardsiella in fishes were discussed.
Effect of atmospheric stability on the wind resource extrapolating models for large capacity wind turbines: a comparative analysis of power law, log law, Deaves and Harris model (2019)

To observe certain wind climate from the available met mast measured wind data at different heights an accurate wind shear model is necessary. Since WAsP and windPRO is software package which provides the better representation of wind profile over homogeneous terrain only. Though, a separate module named as WAsP CFD has been added in both of the software to predict correct wind resource in complex terrain also. Nowadays wind resource assessment has been widely dependent on terrain and becomes a key issue for the researchers. It has been found experimentally from earlier work that Deaves and Harris model shows a better representation of wind profiles on flat terrain at higher heights in comparison to other models such as the PL (power law), the LogL (log law) and the LogLL (Log-linear law). This study presents a comparative analysis of three different wind extrapolation models. Based on 2 year measured wind data from the met mast the at 10 m, 50 m, 80 m, 100 m and 102 m heights, results were compared in different stability classes using Monin-Obukhuv similarity theory. The RMSE (root mean square error) and NRMSE (normalized root mean square error were found to be least in case of log linear model which is 0.11 and 0.01784 respectively in compare to the PL and Deaves and Harris models.
Sulphur stable isotopes can distinguish trophic dependence on sediments and plankton in boreal lakes (2008)

Summary 1. Stable isotopes of carbon are useful for differentiating between freshwater food chains based on planktonic algae or benthic algae, but are reported to be of limited use for identifying food chains based on sedimentary detritus. Because data from marine systems suggest that stable isotopes of sulphur (δ 34 S values) have potential in this regard, we tested their utility in freshwater lakes. 2. We found that sulphate in the water column of four boreal lakes was enriched in 34 S compared to the sulphur in bulk sediments from these lakes. Furthermore, within a given lake, insects known to feed on sediment (directly or via predation) had δ 34 S values similar to those of sediment, whereas planktonic and benthic invertebrates known to feed on suspended particles had δ 34 S values similar to those of sulphate in the water column. 3. Using the stable S isotope values of invertebrates that obtain their S from either the sediment or the water column as end members in a two‐source mixing model, we show that two fish species obtain their food from both planktonic and sedimentary sources. Furthermore, model results suggest that, as expected, the more benthic‐feeding fish species obtains more of its S from the sediment compartment than does the species that feeds in the water‐column. 4. Our results suggest that measurements of stable sulphur isotopes provide a means of distinguishing between members of food chains that are based in the water column from those based on sedimentary detritus. As such, they would be a useful complement to stable C isotopes that are used to distinguish between food chains based on planktonic or benthic algae.
A Convenient Catalytic Method for the Dihydroxylation of Alkenes by Hydrogen Peroxide (1989)

A simple method for preparing water-soluble vicinal diols from the corresponding water-insoluble alkenes is reported. It is based on the use of tungsten peroxo complexes as catalysts and hydrogen peroxide as the oxidizing agent in a two-phase system.