gebhart/patrepeval huggingface dataset:
A Novel Assisted History Matching Workflow and its Application in a Full Field Reservoir Simulation Model (2019)

The significant increase in using reservoir simulation models poses significant challenges in the design and calibration of models. Moreover, conventional model calibration, history matching, is usually performed using a trial and error process of adjusting model parameters until a satisfactory match is obtained. In addition, history matching is an inverse problem, and hence it may have non-unique solutions. In typical reservoir simulation problems with a large number of unknown parameters, the problem could be ill-posed. In recent years, assisted history matching approach has been offered to solve this problem hopefully. In this paper, proposes an efficient assisted history matching workflow is recommended, and its application in a full field reservoir simulation model of a mature gas-cap reservoir is presented. In addition, Sobol sequence experimental design technique, Kriging proxy modeling, and three novel metaheuristic optimization algorithms are used to assist the history match of 28 years of historical production and pressure data. Finally, the results are compared with those obtained using a manual history matching procedure and with those obtained using the most widely used assisted history matching workflow. Also, in the proposed workflow, a significant improvement in terms of match quality and solution time is shown.
Capillary Blood Sampling for Self-Monitoring of Blood Glucose (1999)

New and emerging capillary blood sampling technologies for self-monitoring of blood glucose (SMBG) are reviewed for their impact on factors pertaining to users such as pain, and from the standpoint of skin physiology and technical feasibility. Innovative blood sampling techniques based on lancets for skin penetration on nonfinger (alternate) sites such as the forearm seem to be virtually painless, convenient and cost effective as compared to other methods such as laser-based perforation of fingertips. Alternate site blood sampling with new lancet devices appears not only medically sound but also technically practical and user-friendly. It is anticipated that alternate site blood sampling techniques would improve compliance rate and, consequently, outcome of treatment for patients with diabetes.
Data from Targeted Therapy for <i>BRAF<sup>V600E</sup></i> Malignant Astrocytoma (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Malignant astrocytomas (MA) are aggressive central nervous system tumors with poor prognosis. Activating mutation of &lt;i&gt;BRAF&lt;/i&gt; (&lt;i&gt;BRAF&lt;sup&gt;V600E&lt;/sup&gt;&lt;/i&gt;) has been reported in a subset of these tumors, especially in children. We have investigated the incidence of &lt;i&gt;BRAF&lt;sup&gt;V600E&lt;/sup&gt;&lt;/i&gt; in additional pediatric patient cohorts and examined the effects of BRAF blockade in preclinical models of &lt;i&gt;BRAF&lt;sup&gt;V600E&lt;/sup&gt;&lt;/i&gt; and wild-type &lt;i&gt;BRAF&lt;/i&gt; MA.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt;&lt;i&gt;BRAF&lt;sup&gt;V600E&lt;/sup&gt;&lt;/i&gt; mutation status was examined in two pediatric MA patient cohorts. For functional studies, &lt;i&gt;BRAF&lt;sup&gt;V600E&lt;/sup&gt;&lt;/i&gt; MA cell lines were used to investigate the effects of &lt;i&gt;BRAF&lt;/i&gt; shRNA knockdown &lt;i&gt;in vitro&lt;/i&gt;, and to investigate BRAF pharmacologic inhibition &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt;.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt;&lt;i&gt;BRAF&lt;sup&gt;V600E&lt;/sup&gt;&lt;/i&gt; mutations were identified in 11 and 10% of MAs from two distinct series of tumors (six of 58 cases total). BRAF was expressed in all MA cell lines examined, among which &lt;i&gt;BRAF&lt;sup&gt;V600E&lt;/sup&gt;&lt;/i&gt; was identified in four instances. Using the BRAF&lt;sup&gt;V600E&lt;/sup&gt;-specific inhibitor PLX4720, pharmacologic blockade of BRAF revealed preferential antiproliferative activity against &lt;i&gt;BRAF&lt;sup&gt;V600E&lt;/sup&gt;&lt;/i&gt; mutant cells &lt;i&gt;in vitro&lt;/i&gt;, in contrast to the use of shRNA-mediated knockdown of &lt;i&gt;BRAF&lt;/i&gt;, which inhibited cell growth of glioma cell lines regardless of &lt;i&gt;BRAF&lt;/i&gt; mutation status. Using orthotopic MA xenografts, we show that PLX4720 treatment decreases tumor growth and increases overall survival in mice-bearing &lt;i&gt;BRAF&lt;sup&gt;V600E&lt;/sup&gt;&lt;/i&gt; mutant xenografts, while being ineffective, and possibly tumor promoting, against xenografts with wild-type &lt;i&gt;BRAF&lt;/i&gt;.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Our results indicate a 10% incidence of activating &lt;i&gt;BRAF&lt;sup&gt;V600E&lt;/sup&gt;&lt;/i&gt; among pediatric MAs. With regard to implications for therapy, our results support evaluation of BRAF&lt;sup&gt;V600E&lt;/sup&gt;-specific inhibitors for treating BRAF&lt;sup&gt;V600E&lt;/sup&gt; MA patients. &lt;i&gt;Clin Cancer Res; 17(24); 7595–604. ©2011 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
La fièvre de Lassa : réponses immunes et pathogenèse. (2012)

Lassa fever is a hemorrhagic fever endemic to West Africa and caused by Lassa virus, an Old-World arenavirus. It may be fatal, but most patients recover from acute disease and some experience asymptomatic infection. The immune mechanisms associated with these different outcomes have not yet been fully elucidated, but considerable progress has recently been made, through the use of in vitro human models and non-human primates, the only relevant animal model that mimics the pathophysiology and immune responses induced in patients. We discuss here the roles of the various components of the innate and adaptive immune systems in Lassa virus infection and in the control of viral replication and pathogenesis.
A multicamera setup for generating stereo panoramic video (2005)

Traditional visual communication systems convey only two-dimensional (2-D) fixed field-of-view (FOV) video information. The viewer is presented with a series of flat, nonstereoscopic images, which fail to provide a realistic sense of depth. Furthermore, traditional video is restricted to only a small part of the scene, based on the director's discretion and the user is not allowed to "look around" in an environment. The objective of this work is to address both of these issues and develop new techniques for creating stereo panoramic video sequences. A stereo panoramic video sequence should be able to provide the viewer with stereo vision at any direction (complete 360-degree FOV) at video rates. In this paper, we propose a new technique for creating stereo panoramic video using a multicamera approach, thus creating a high-resolution output. We present a setup that is an extension of a previously known approach, developed for the generation of still stereo panoramas, and demonstrate that it is capable of creating high-resolution stereo panoramic video sequences. We further explore the limitations involved in a practical implementation of the setup, namely the limited number of cameras and the nonzero physical size of real cameras. The relevant tradeoffs are identified and studied.
Metal-Oxidant Igniter Materials (1956)

An investigation of the physical and chemical factors affecting propellant ignition is being conducted with the ultimate objective of producing information useful in the design and development of ignition systems for solid- propellant rockets. This investigation has largely been concerned with a study of the materials used to ignite rocket motors, that is, black powder and metal- oxidant formulations. This paper presents the results of calculations made on five metal fuels with conventional oxidizers to determine, under adiabatic conditions, what maximum flame temperatures could be reached and what the physical states of the products might be. Results of experimental characterization studies covered in this paper include determinations of heats of explosion, gas volumes produced, and the effectiveness of various igniter compositions in igniting a propellant specimen in a laboratory ignitibility test. In addition, unusual ignitibility effectiveness of fuel-rich magnesium- potassium nitrate mixtures is discussed in terms of a secondary ignition effect of igniter combustion products, and the results of a limited investigation of factors affecting the combustion rate of elemental boron are given.
Wood’s anomalies for arrays of dielectric scatterers (2014)

The Rayleigh Wood anomalies refer to an unexpected repartition of the electromagnetic energy between the several interference orders of the light emerging from a grating. Since Hessel and Oliner (Appl. Opt. 4 , 1275-1297 (1965)), several studies have been dedicated to this problem, focusing mainly on the case of metallic gratings. In this paper, we derive explicit expressions of the reflection coefficients in the case of dielectric gratings using a perturbative approach. This is done in a multimodal description of the field combined with the use of the admittance matrix, analog to the so-called electromagnetic impedance. Comparisons with direct numerical calculations show a good agreement with our analytical prediction.
Infrared spectra at coupled cluster accuracy from neural network representations (2022)

Infrared spectroscopy is key to elucidate molecular structures, monitor reactions and observe conformational changes, while providing information on both structural and dynamical properties. This makes the accurate prediction of infrared spectra based on first-principle theories a highly desirable pursuit. Molecular dynamics simulations have proven to be a particularly powerful approach for this task, albeit requiring the computation of energies, forces and dipole moments for a large number of molecular configurations as a function of time. This explains why highly accurate first principles methods, such as coupled cluster theory, have so far been inapplicable for the prediction of fully anharmonic vibrational spectra of large systems at finite temperatures. Here, we push cutting-edge machine learning techniques forward by using neural network representations of energies, forces and in particular dipoles to predict such infrared spectra fully at "gold standard" coupled cluster accuracy as demonstrated for protonated water clusters as large as the protonated water hexamer, in its extended Zundel configuration. Furthermore, we show that this methodology can be used beyond the scope of the data considered during the development of the neural network models, allowing for the computation of finite-temperature infrared spectra of large systems inaccessible to explicit coupled cluster calculations. This substantially expands the hitherto existing limits of accuracy, speed and system size for theoretical spectroscopy and opens up a multitude of avenues for the prediction of vibrational spectra and the understanding of complex intra- and intermolecular couplings.
Injectivity Profiling in Horizontal Wells Through Distributed Temperature Monitoring (2005)

Abstract Downhole permanent monitoring sensors offer unique options for continuous evaluating flow regimes, completion integrity, formation properties, flow assurance effectiveness and optimal production/injection operations. The use of temperature data for vertical injection wells has been widely applied in practice and has been thoroughly discussed in literature. The problems occur for Distributed Temperature Sensors (DTS) installed in horizontal well due to small variations of geothermal temperature along the wellbore. Unlike the conventional gauges, DTS data are acquired in both temporal and spatial dimensions that exploit the great potential for real-time operation optimization. We present an interpretation technique for analysis of temperature profiles recorded with fiber optic distributed temperature sensor (DTS) in horizontal water injectors. Simple semi analytical models were developed for simulating mass and heat transfer in horizontal well and collector during injection and warm back. Two inversion procedures based on these models were developed allowing calculation of injectivity profile from temperature profiles recorded during injection and warm-back. These procedures were successfully validated on CFD numerical model and tested on field data.
Characteristics of older people in an inpatient haematology unit: A descriptive study (2018)

Haematologists care for older inpatients who are complex with multidisciplinary health service needs. There may be value in conducting comprehensive geriatric assessments in this setting.
New reward and penalty scheme for electric distribution utilities employing load‐based reliability indices (2018)

Electric distribution utilities are required to continuously deliver reliable electric power to their customers. Regulatory utility commissions often practise reward and penalty schemes to regulate reliability performance of utility companies annually with respect to a desired performance targets. However, the conventional regulation procedures are commonly found based on the customer‐based standard reliability indices, which are not able to discern the service characteristics behind the electric meters and, hence, fail to holistically characterise the actual impact of electricity interruption. This study proposes a new method to evaluate the load‐based reliability indices in power distribution systems using advanced metering infrastructure data. Furthermore, the authors introduce a reward/penalty regulation scheme for utility regulators to provide a reliability oversight using the proposed load‐based reliability metrics. The new load‐based reliability metric and the reward/penalty scheme proposed bring about superior advantages as the distribution grids become further complex with a high penetration of distributed energy resources and enabled microgrid flexibilities. Numerical analyses on different settings with and without microgrid considerations reveal the applicability and effectiveness of the proposed approach in real‐world scenarios.
Transition-Metal-Free Cyclization of Propargylic Alcohols with Aryne: Synthesis of 3-Benzofuranyl-2-oxindole and 3-Spirooxindole Benzofuran Derivatives (2018)

An unprecedented base-mediated cyclization of propargylic alcohols with aryne is reported, providing a novel method for the synthesis of 3-benzofuranyl-2-oxindole and 3-spirooxindole benzofuran scaffolds via a propargyl Claisen rearrangement/cycloaddition pathway. The nature of the substituent on acetylene group of propargylic alcohol influences the outcome of the reaction. The protocol offers a transition-metal-free and operationally simple methodology with broad substrate scope as a ready access to complex oxindole-linked heterocyclic compounds.
Rapid Onset of Intestinal Epithelial Barrier Dysfunction in Primary Human Immunodeficiency Virus Infection Is Driven by an Imbalance between Immune Response and Mucosal Repair and Regeneration (2007)

Gut-associated lymphoid tissue (GALT) is an early target for human immunodeficiency virus type 1 (HIV-1) infection and is a site for severe CD4(+) T-cell depletion. HIV-associated enteropathy is well-documented in chronic HIV-1 infection. However, the initial host responses to HIV infection in GALT and the early molecular correlates of HIV enteropathogenesis have not been characterized during primary HIV infection. In this study, we provide evidence of viral replication in GALT resident CD4(+) T cells and macrophages in primary-stage patients and identify early patterns of host mucosal responses and changes in the molecular microenvironment through gene expression profiling. High levels of viral replication in GALT and marked CD4(+) T-cell depletion correlated with decreased expression levels of genes regulating epithelial barrier maintenance and digestive/metabolic functions. These changes coincided with a marked increase in the transcription of immune activation-, inflammation-, and apoptosis-associated genes. Our findings indicate that HIV-induced pathogenesis in GALT emerges at both the molecular and cellular levels prior to seroconversion in primary HIV infection, potentially setting the stage for disease progression by impairing the ability to control viral replication and repair and regenerate intestinal mucosal tissues.
Supplementary Figure S1 from Preclinical Pharmacokinetics, Tolerability, and Pharmacodynamics of Metuzumab, a Novel CD147 Human–Mouse Chimeric and Glycoengineered Antibody (2023)

&lt;p&gt;Supplementary Figure S1. Images of anti-tumor efficacy of Metuzumab in SCID mice bearing A549 (left) and NCI-H520 (right) human lung cancer cell line xenografts.&lt;/p&gt;
Carotenoid analysis of sweetpotatoIpomoea batatasand functional identification of its lycopene β- and ε-cyclase genes (2016)

Sweetpotato Ipomoea batatas is known as a hexaploid species. Here, we analyzed carotenoids contained in the leaves and tubers of sweetpotato cultivars 'White Star' (WS) and W71. These cultivars were found to contain several carotenoids unique to sweetpotato tubers such as β-carotene-5,6,5',8'-diepoxide and β-carotene-5,8-epoxide. Next, we isolated two kinds of carotene cyclase genes that encode lycopene β- and ε-cyclases from the WS and W71 leaves, by RT-PCR and subsequent RACE. Two and three lycopene β-cyclase gene sequences were, respectively, isolated from WS, named IbLCYb1, 2, and from W71, IbLCYb3, 4, 5. Meanwhile, only a single lycopene ε-cyclase gene sequence, designated IbLCYe, was isolated from both WS and W71. These genes were separately introduced into a lycopene-synthesizing Escherichia coli transformed with the Pantoea ananatis crtE, crtB and crtI genes, followed by HPLC analysis. β-Carotene was detected in E. coli cells that carried IbLCYb1-4, indicating that the IbLCYb1-4 genes encode lycopene β-cyclase. Meanwhile, the introduction of IbLCYe into the lycopene-synthesizing E. coli led to efficient production of δ-carotene with a monocyclic ε-ring, providing evidence that the IbLCYe gene codes for lycopene ε-(mono)cyclase. Expression of the β- and ε-cyclase genes was analyzed as well.
Changes in learning and memory after single and simultaneous lesion of the serotonergic and noradrenergic systems in the rat (2006)

Background Noradrenergic (NA) and serotonergic (5-HT) pathways play an inevitable role in several crucial central nervous system functions such as learning and memory, sleep, food-consumption and mood. Slight changes in the state of equilibrium of these neurotransmitters can lead to the development of severe psychiatric states. Dysfunction of these systems may be responsible for the considerable deficits of memory and learning processes occuring in mood and anxiety disorders. Nevertheless the exact mechanism by which these monoamines influence these processes are not yet fully understood. The way of interaction of these two systems between each other and with other neurotransmitters and neuromodulators is still an interesting field of CNS-research.
CYP2D6 mRNA expression in circulating peripheral blood mononuclear cells correlates with in vivo debrisoquine hydroxylase activity in extensive metabolizers. (1996)

Extensive metabolizers of drugs which are oxidized by cytochrome P450s show wide interindividual variability in drug metabolism. Elucidation of the relationship between specific P450 isozyme mRNA expression and variability in metabolism of specific drugs could improve understanding of the molecular mechanism involved. In this study, a novel non-radiometric reverse transcription polymerase chain reaction based assay was used to quantify CYP2D6 mRNA levels in peripheral blood mononuclear cells in twelve human volunteers who were phenotyped as extensive metabolizers of debrisoquine. We report a significant correlation (r=0.724, p= 0.008) between CYP2D6 mRNA levels in circulating peripheral blood mononuclear cells and the in vivo debrisoquine recovery ratio. This suggests that interindividual variability in extensive metabolizers could be related, in part, to differences in gene expression. Circulating peripheral blood mononuclear cells can provide an accessible ex vivo measure of this phenomenon.
Exploring the design space for notification servers (1998)

Article Free Access Share on Exploring the design space for notification servers Authors: Devina Ramduny School of Computing, Staffordshire University, Stafford ST18 ODG UK School of Computing, Staffordshire University, Stafford ST18 ODG UKView Profile , Alan Dix School of Computing, Staffordshire University, Stafford ST18 ODG UK School of Computing, Staffordshire University, Stafford ST18 ODG UKView Profile , Tom Rodden Computing Department SECaMS, Lancaster University, Lancaster LA1 4YR UK Computing Department SECaMS, Lancaster University, Lancaster LA1 4YR UKView Profile Authors Info & Claims CSCW '98: Proceedings of the 1998 ACM conference on Computer supported cooperative workNovember 1998 Pages 227–235https://doi.org/10.1145/289444.289497Published:01 November 1998Publication History 25citation519DownloadsMetricsTotal Citations25Total Downloads519Last 12 Months21Last 6 weeks7 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Correction: Mobility shift-based electrophoresis coupled with fluorescent detection enables real-time enzyme analysis of carbohydrate sulfatase activity (2021)

Biochem. J. (2021) 478 (4): 735–748 https://doi.org/10.1042/BCJ20200952The authors would like to make the following corrections to their article. The equation appearing in the section ‘A novel microfuidic-based desulfation assay’ of the Methods, should appear as V0=(kcat/KM)[S][E]. The y-axis in Figure 2H should be ‘Integral’. The corrected version can be seen below. The footnote in Table 1 should read “The table list the kinetic values and the corresponding amount of resources required in terms of time and components. *Indicates value is a specific activity (h−1). All experiments represent technical triplicates.” The authors apologise for any confusion caused by these errors.
Magnetic anisotropy in ordered textured Co nanowires (2012)

The magnetization reversal in ordered arrays of Co nanowires with tailored hcp-phase texture, controlled by pH synthesis and nanowires length, has been investigated. The angular dependence of coercivity has been experimentally determined for different crystal textures, and the corresponding magnetization reversal mode is interpreted by analytical modelling. The results show that reversal takes place by propagation of a transverse-like domain wall mode. The fitting of experimental and calculated data allows us the quantitative evaluation of the magnetocrystalline anisotropy constant strength whose magnetization easy direction evolves from parallel to the wires toward in-plane orientation with the change of hcp-phase texture.