gebhart/patrepeval huggingface dataset:
Increased cyclic adenosine 3':5'-monophosphate phosphodiesterase activity in the epidermis of phorbol ester-treated mouse skin and in papillomas. (1979)

The potent tumor promoter, 12-O-tetradecanoylphorbol-13-acetate, produced a 2- to 3-fold increase in the activity of both the low- and high-affinity forms of cyclic adenosine 3':5'-monophosphate phosphodiesterase activity 13 hr after application to mouse skin. The magnitude of the enzyme induction correlated with the tumor-promoting activity of several doses of 12-O-tetradecanoylphorbol-13-acetate and of other phorbol esters. The induction of the low-affinity phosphodiesterase could be blocked by prior i.p. injection of the microtubule poisons, colchicine and vinblastine. The low-affinity cyclic adenosine 3':5'-monophosphate phosphodiesterase activity of the epidermal component of mouse skin papillomas produced by two-stage tumorigenesis was 3 times that of the surrounding uninvolved epidermis.
Treatment of suicidal people around the world (2011)

Most people with suicide ideation, plans and attempts receive no treatment. This is a consistent and pervasive finding, especially in low-income countries. Improving the receipt of treatment worldwide will have to take into account culture-specific factors that may influence the process of help-seeking.
Échafaudages - Différentes destinations. Mise en œuvre (2007)

L’objet de cet article est de détailler les différentes destinations ainsi que la mise en oeuvre des échafaudages. Dans un premier temps, des descriptions, des caractéristiques et des charges pour certaines structures couramment employées sont proposées. Les exemples sont les échafaudages de service, façade de pied cadres ou modulaires, les échafaudages de service autres que les façades, l’étaiement et les structures provisoires. Dans un second temps, l’organisation du chantier est explicitée à travers les étapes de montage, démontage et entretien. Le tout est agrémenté de conseils pour la mise en oeuvre.
A Novel Malate Dehydrogenase 2 Inhibitor Suppresses Hypoxia-Inducible Factor-1 by Regulating Mitochondrial Respiration (2016)

We previously reported that hypoxia-inducible factor (HIF)-1 inhibitor LW6, an aryloxyacetylamino benzoic acid derivative, inhibits malate dehydrogenase 2 (MDH2) activity during the mitochondrial tricarboxylic acid (TCA) cycle. In this study, we present a novel MDH2 inhibitor compound 7 containing benzohydrazide moiety, which was identified through structure-based virtual screening of chemical library. Similar to LW6, compound 7 inhibited MDH2 activity in a competitive fashion, thereby reducing NADH level. Consequently, compound 7 reduced oxygen consumption and ATP production during the mitochondrial respiration cycle, resulting in increased intracellular oxygen concentration. Therefore, compound 7 suppressed the accumulation of HIF-1α and expression of its target genes, vascular endothelial growth factor (VEGF) and glucose transporter 1 (GLUT1). Moreover, reduction in ATP content activated AMPK, thereby inactivating ACC and mTOR the downstream pathways. As expected, compound 7 exhibited significant growth inhibition of human colorectal cancer HCT116 cells. Compound 7 demonstrated substantial anti-tumor efficacy in an in vivo xenograft assay using HCT116 mouse model. Taken together, a novel MDH2 inhibitor, compound 7, suppressed HIF-1α accumulation via reduction of oxygen consumption and ATP production, integrating metabolism into anti-cancer efficacy in cancer cells.
Solid-State Characterization and Photoinduced Intramolecular Electron Transfer in a Nanoconfined Octacationic Homo[2]Catenane (2014)

An octacationic homo[2]catenane comprised of two mechanically interlocked cyclobis(paraquat-p-phenylene) rings has been obtained from the oxidation of the septacationic monoradical with nitrosonium hexafluoroantimonate. The nanoconfinement of normally repulsive bipyridinium units results in the enforced π-overlap of eight positively charged pyridinium rings in a volume of <1.25 nm(3). In the solid state, the torsional angles around the C-C bonds between the four pairs of pyridinium rings range between 16 and 30°, while the π-π stacking distances between the bipyridinium units are extended for the inside pair and contracted for the pairs on the outside--a consequence of Coulombic repulsion between the inner bipyridinium subunits. In solution, irradiation of the [2]catenane at 275 nm results in electron transfer from one of the paraphenylene rings to the inner bipyridinium dimer, leading to the generation of a temporary mixed-valence state within the rigid and robust homo[2]catenane.
The co‐expression of 2B4 (CD244) and CD160 delineates a subpopulation of human CD8+ T cells with a potent CD160‐mediated cytolytic effector function (2006)

Within human CD8+ T lymphocytes, the CD27-CD45RAhigh or CD56+ phenotypes contribute to precisely define the cells with CTL effector function. Novel markers were demonstrated to correlate with CTL properties, such as the 2B4 (CD244) receptor, a member of the CD2 subset of the immunoglobulin superfamily or the glycosylphosphatidylinositol-anchored CD160 receptor. We performed a study of these markers to further define the population of effectors with CTL functions. Here we show that cytotoxic subpopulations defined by surface markers CD160, CD56 and CD57 are mostly contained in the 2B4+CD8+ T cell population. Expression of CD160 identifies two populations in the 2B4+ population. The 2B4+CD160+ subset expresses a bona fide CTL phenotype. The co-expression of 2B4 and CD160 defines T cells containing high amounts of perforin and granzyme B. During CTL ontogeny, an up-regulation of 2B4 and CD160 is observed from a naive to a terminally differentiated phenotype. Finally, we demonstrated that CD160 triggering failed to induce cytotoxicity per se, but costimulated CD3-redirected killing. We conclude that the co-expression of 2B4 and CD160 defines a CD8+ T lymphocyte subpopulation with high CTL activity.
Enhancement of mass spectrometry performance for proteomic analyses using highfield asymmetric waveform ion mobility spectrometry (FAIMS) (2015)

Large-scale proteomics is typically achieved using a bottom-up approach whereby cell extracts are proteolytically digested into peptides prior to their analysis by liquid chromatography—tandem mass spectrometry (LC—MS/MS). While this strategy is largely preferred for comprehensive protein identification, the corresponding conversion of proteins to peptides significantly increases sample complexity, and typically results in tens of thousands of peptides placing considerable demands on MS instruments to obtain in-depth proteome coverage. Current MS instrumentation enables the detection of more than 100 000 peptides in a single run, although the large majority remains inaccessible to data-dependent LC—MS/MS. In this perspective Special Feature, Pierre Thibault and co-workers describe the use of high-field asymmetric waveform ion mobility spectrometry (FAIMS) and evaluate its analytical merits for proteomic applications. Pierre Thibault is Professor of Chemistry at the Université de Montréal (Montreal QC, Canada). His main research interests are in the development and implementation of new technologies in proteomics and cell biology. In multidisciplinary research, these tools provide a deeper understanding of molecular mechanisms and posttranslational modifications, which regulate the function and translocation of proteins involved in immunity and signalling in cancer cells.
High Performance High Density Gas-FET Array in Standard CMOS (2018)

New gas sensitive FET (Gas-FET) structures are proposed to enable standard CMOS fabrication of high performance high density gas sensor arrays that are fully integrated with their associated circuitry. The performance of the proposed Gas-FET structures was investigated by fabricating an 8×8 Gas-FET array comprising 45μm×46μm sensing elements. Room temperature sub-ppm acetone sensing capability is demonstrated for non-invasive diabetes diagnosis through exhaled human breath. Performance comparison shows that the fabricated array boasts superior sensitivity while enabling ultra-low power operation at room temperature, with over 3 orders magnitude reduction in power consumption compared to previously reported standard CMOS resistive gas sensors.
Intestinal permeation mediated absorption interactions between atenolol and furosemide (2003)

Peroral multi-drug administration is often associated with severe drug-drug interactions. These interactions can occur either in the gut lumen, at absorptive site or after absorption. Present work was undertaken to study the interaction between atenolol and furosemide at the absorption site. Alteration in the intestinal permeability was studied using rat single-pass intestinal perfusion technique, to assess the changes on administration of single and combination drugs. Permeability coefficient (Peff) of atenolol reduced to a statistically significant level (P<0.05) when co-perused with furosemide, with Peff, values (X10-4 cm/sec) of 0.0686Â±0.0433 and 0.01 54Â±0.0326 for drug perfused individually and in combination, respectively, indicating the possibility of drug-drug interaction occurring at the absorption site.
Digitalsimulator für pulscodierte neuronale Netze (2005)

Abstract. Die Simulation von grossen pulscodierten neuronalen Netzen (PCNNs) für die Evaluierung einer biologisch motivierten Bildverarbeitung ist auf Einprozessor-Systemen (PCs oder Workstations) immer noch sehr zeitineffizient. Den Flaschenhals während der Simulation bildet der sequentielle Zugriff auf den Gewichtsspeicher zur Berechnung der Neuronenzustände. Es wird ein Digitalsimulator basierend auf feld-programmierbaren Gate-Arrays (FPGAs) vorgestellt, der dieses Flaschenhals-Problem durch eine verteilte Speicherarchitektur und eine erhöhte Speicherbandbreite angeht und zusätzlich eine getrennte Berechnung von Neuronenzuständen und Netzwerktopologie vorsieht. Somit ist es möglich, den des Simulationsalgorithmus zu erhöhen. Die momentane Implementierung mit einer Taktfrequenz von 50MHz verspricht einen Beschleunigungsfaktor von etwa 30 für eine spärliche Vernetzungsstruktur (Vierer- und Achternachbarschaft) im Vergleich zu einem PC mit einer 2,4GHz CPU und 1GB RAM Arbeitsspeicher.
Recycling ZnTe, CdTe, and Other Compound Semiconductors by Ambipolar Electrolysis (2011)

The electrochemical behavior of ZnTe and CdTe compound semiconductors dissolved in molten ZnCl(2) and equimolar CdCl(2)-KCl, respectively, was examined. In these melts dissolved Te is present as the divalent telluride anion, Te(2-), which was found able to be converted to elemental metal by electrochemical oxidation at the anode. ZnTe-ZnCl(2) melts were studied at 500 °C by standard electrochemical techniques. On the basis of these results, electrolysis was performed, resulting in the simultaneous extraction of phase-pure liquid Zn at the cathode and phase-pure liquid Te at the anode. This new process, involving the simultaneous deposition of liquid metals at electrodes of opposite polarity, is termed herein as ambipolar electrolysis. A melt consisting of CdTe dissolved in equimolar CdCl(2)-KCl was processed by ambipolar electrolysis, resulting in the production of liquid Cd at the cathode and liquid Te at the anode. Ambipolar electrolysis could enable new approaches to recycling compound semiconductors and semiconductor devices, such as CdTe solar cells.
Effects of lipoxygenase inhibitors in arachidonate-induced sudden death (1984)

Both BW 755c, a cyclo-oxygenase and lipoxygenase inhibitor, and nordihydroguaiaretic acid (NDGA), a selective lipoxygenase inhibitor, were tested for their protection against arachidonate-induced sudden death in rabbits. 100% survival was seen with BW 755c (1 mg kg-1), while NDGA showed 0 and 17% survival (2 mg kg-1 and 4 mg kg-1). BW 755c prevented 12-fold increase in plasma thromboxane B2 concentrations and the formation of pulmonary artery thrombi normally seen with arachidonate-induced sudden death, while NDGA showed no such protective effect. Radioimmunoassay of rabbit plasma for leukotrienes (LTC4, LTD4 and LTE4) indicated that they do not accumulate in blood in the model and BW 755c had no effect, suggesting that the deleterious effects seen are caused by cyclo-oxygenase pathway metabolites such as thromboxane A2, but not by lipoxygenase pathway products such as leukotrienes.
Simulating Time-Series Data for Improved Deep Neural Network Performance (2019)

Deep learning algorithms have shown remarkable performance in classification tasks, however, they typically perform poorly with small training datasets due to overfitting. Overfitting occurs for all data types, although for the purposes of this study we are interested in time-based signals. This study introduces a novel technique to simulate time series signals from a dataset of categorically labeled data which can be used to train a deep neural network. The objective is to improve the predictive accuracy of a deep neural network on a separate validation dataset. To demonstrate the simulation methodology and improvements to the model's performance, a small dataset of ground reaction forces was used with the goal of identifying a person based on the raw signal. Our results show that the simulation method presented improves validation accuracy and reduces model training time for each of the three signal types.
Highly selective detection of 5-methylcytosine using photochemical ligation (2008)

We report the nonenzymatic detection of 5-methylcytosine by using template-directed photoligation through 5-cyanovinyl-2'-deoxyuridine ((C)U) with high selectivity and present a new methylation detection method using a photoligation-based DNA chip assay.
A Bioinformatics-Based Bottom-up Network Reconstruction Approach to Detect Stem Cell-Related Blood Biomarkers of Cardiovascular Damage and Repair (2014)

Health Professions - Laboratory/Cellular: 3rd Place (The Ohio State University Denman Undergraduate Research Forum)
Concerning trans-Acylation in Azlactone Synthesis (1951)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConcerning trans-Acylation in Azlactone SynthesisSerge N. Timasheff and F. F. NordCite this: J. Am. Chem. Soc. 1951, 73, 5, 2390Publication Date (Print):May 1, 1951Publication History Published online1 May 2002Published inissue 1 May 1951https://doi.org/10.1021/ja01149a545RIGHTS & PERMISSIONSArticle Views106Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (157 KB) Get e-Alerts Get e-Alerts
A new technique for hardening optically-triggered thyristors (1990)

Optically-triggered thyristors are hardened to high x-ray dose rates by the addition of a monolithically integrated compensating photodetector. Tests of discrete device arrangements show radiation-induced switching is completely inhibited up to 1.4 {times} 10{sup 9} rad (Si)/sec. 1 ref., 4 figs.
Vapor transport epitaxy, a novel growth technique for compound semiconductors (1992)

An advanced vapor transport epitaxy (VTE) technique for depositing compound semiconductors is described. The technique operates in the 10−1–10−6 Torr range using elemental, gas, or metalorganic sources. We have previously demonstrated elemental VTE oval defect-free growth of several microns of GaAs at growth rates exceeding one micron per hour, on GaAs (100) and (111) 2° off toward 〈110〉 substrates. Elemental VTE is reviewed, and the effects of hydrogen on elemental VTE are discussed. The deposition process for GaAs films using metalorganic sources is described and results are presented. Electrical characteristics, as measured by Hall and sheet resistivity, show that films deposited using monoethylarsine and triethylgallium are n type as deposited. The resolving of several problems common to molecular-beam epitaxy, chemical-beam epitaxy, and metalorganic chemical vapor deposition systems has been the motivation for investigation of this technique.
Cloning and expression of human angiogenin gene (2008)

In order to obtain much more purified human angiogenin,we expressed it in E.coli BL21.The angiogenin was amplified by PCR method from the human melanoma cell line A375 and inserted into the expression vector pET-28a(+) after it was proved to be correct by DNA sequencing.Then the constructed gene was transformed into E.coli BL21 host bacteria.After having been induced by IPTG,the recombinant protein fused with 6His-tag at its N-terminal was expressed successfully.Owing to possessing 6His-tag,the expressed protein can be purified by Ni2+ resin according to the high affinity of 6His-tag with Ni2+.
UnCRtainTS: Uncertainty Quantification for Cloud Removal in Optical Satellite Time Series (2023)

Clouds and haze often occlude optical satellite images, hindering continuous, dense monitoring of the Earth's surface. Although modern deep learning methods can implicitly learn to ignore such occlusions, explicit cloud removal as pre-processing enables manual interpretation and allows training models when only few annotations are available. Cloud removal is challenging due to the wide range of occlusion scenarios -- from scenes partially visible through haze, to completely opaque cloud coverage. Furthermore, integrating reconstructed images in downstream applications would greatly benefit from trustworthy quality assessment. In this paper, we introduce UnCRtainTS, a method for multi-temporal cloud removal combining a novel attention-based architecture, and a formulation for multivariate uncertainty prediction. These two components combined set a new state-of-the-art performance in terms of image reconstruction on two public cloud removal datasets. Additionally, we show how the well-calibrated predicted uncertainties enable a precise control of the reconstruction quality.
ACOG Committee on Obstetric Practice Number 291, November 2003: Use of Progesterone to Reduce Preterm Birth (2003)

Preterm birth affects 12% of all births in the United States. Recent studies support the hypothesis that progesterone supplementation reduces preterm birth in a select group of women (ie, those with a prior spontaneous birth at <37 weeks of gestation). Despite the apparent benefits of progesterone in this high-risk population, the ideal progesterone formulation is unknown. The American College of Obstetricians and Gynecologists Committee on Obstetric Practice believes that further studies are needed to evaluate the use of progesterone in patients with other high-risk obstetric factors, such as multiple gestations, short cervical length, or positive test results for cervicovaginal fetal fibronectin. When progesterone is used, it is important to restrict its use to only women with a documented history of a previous spontaneous birth at less than 37 weeks of gestation because unresolved issues remain, such as optimal route of drug delivery and long-term safety of the drug.
Aseptic Conditions to Reduce Risks to Metabolic Fidelity (2020)

Mitochondria are derived from bacteria, which puts them at risk of stress from antibiotics commonly used in cell culture. Antibiotics have been found to cause metabolic changes in cells in vitro, fundamentally altering cellular function and response. We have been culturing without antibiotics for over 8 years using the aseptic conditions in the closed Xvivo System and we have not had a single culture contaminated. With the hypothesis that routine disinfection and the conditions inside the chambers would manage microbial risks without antibiotics, we performed routine cell culture processes (cell thaw, cell passage, cell harvest) using highly permissive color‐changing TSB bacterial broth. In 4 trials, no contamination was found of any mock cultures. Monitoring of the environment inside the system with bacterial contact plates showed no evidence of contamination. Positive and negative controls showed appropriate growth. Our results showed that adding antibiotics is not necessary for aseptic conditions of cell culture, which highly reduces the metabolic risk to cells and would enhance normal cellular functions and responses in vitro.
Sulphur–carbon composites for Li/S batteries (2013)

Structural and electrochemical properties of various types of sulphur–carbon composites were reviewed to propose approaching ways for the development of lithium/sulphur battery with high energy density and good cycle performance. To improve the electrochemical properties of a sulphur cathode, carbon and polymer materials are applied to sulphur composites: multiwalled nanotube (MWNT), graphene, CMK-3 and activated carbon; and polyaniline (PANi), polyacrylonitrile and polythiophene (PTh). These can serve conducting paths and a polysulphide reservoir to enhance the electrical conductivity of the sulphur cathode and effectively prevent dissolution of polysulphides. And the composites are categorised in two parts such as mixed type sulphur composites and embedded type sulphur composites. Among the sulphur–carbon composites, the hollow carbon capsule/S composite prepared by a geometric control and an infusion method of sulphur in sulphur carbon composite electrode, demonstrated the best electrochemical properties.
Incidence and remaining lifetime risk of Parkinson disease in advanced age (2009)

Our study provides evidence that the incidence of Parkinson disease (PD) in men increases through age 89 years. Whether the subsequent decline represents a true decrease in risk remains to be established. A history of smoking substantially decreased the incidence and lifetime risk of PD. Incidence studies that do not adjust for competing risks of death may overestimate the true risk of PD in the elderly.
Prioritized transmission of variable bit rate MPEG video (2003)

The traffic characteristics of an MPEG coder which generates a high-priority and a low-priority bit stream are studied. The prioritization scheme for the coder assigns components of the data stream to each priority level based on the value of a parameter B. Statistics of both high- and low-priority cells for a pure intraframe and a mixed interframe/intraframe coder are presented. In particular, the probability mass functions on a cells per slice basis of the high-priority and low-priority component for various values of B are shown. Statistics gathered from this type of prioritization scheme can be applied in several ways for network design and operation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>