gebhart/patrepeval huggingface dataset:
[Subtotal reconstructive laryngectomy: author's experience]. (1989)

The authors conclude 18 year's experience with reconstructive laryngectomy by adopting two surgical techniques for intrinsic laryngeal tumors. The first, where one or both of the arytenoids are conserved, can be applied in cases of supraglottic neoplasms extending to the glottis as well as in glottic cancers where a simple cordectomy is not feasible. In both cases this technique is indicated when at least one arytenoid is respected. The second technique involves removal of both arytenoids and is used in cases of intrinsic supraglottic or glottic tumors extended to both arytenoids. The anatomic-pathological criteria supporting these techniques are: 1) the presence of a fibrous ligament anterior to the arytenoid vocal process. This makes possible proper exeresis within healthy tissue (as can be done in supraglottic surgery due to the anatomic characteristics at the anterior commissure level); 2) neoplastic infiltration of the cricoid cartilage takes place exceptionally in supraglottic and glottic neoplasms; in such cases neoplastic manifestation can be radiographically identified. Generally removal of the soft tissues and of the perichondrium within the cricoid area grants conservative surgery the same oncological radicality as that of total laryngectomy. Insights into restoration of laryngeal function when employing the arytenoid-preserving technique are as follows: 1) conservation of the recurrent nerve(s) 2) pulling the base of the tongue back and downward; close to the crico-arytenoid structure can be achieved by crico-hyoid-pexy. In the technique involving removal of the arytenoid: 1) reconstruction of two pseudo-arytenoids 2) the base of the tongue has to be brought close to the edge of the cricoid cartilage possibly by crico-hyoid-pexy. A total of 21 patients have undergone surgery with these techniques since 1984 and to date no neoplastic recurrences have been observed. Those who underwent surgery where the arytenoids were preserved (16 cases) showed laryngeal functional recovery times similar to those for supraglottic surgery. The recovery times were longer for those undergoing bilateral arytenoidectomy (5) and this was especially so for swallowing.
Draft Genome Sequence of Proteus mirabilis Strain UMB0038, Isolated from the Female Bladder (2020)

<i>Proteus mirabilis</i> is a Gram-negative motile and rod-shaped bacterium that is a common pathogen of the urinary tract. Here, we report the draft genome sequence of <i>P. mirabilis</i> UMB0038, which was isolated from a woman without lower urinary tract symptoms.
Molecular State of Active Pharmaceutical Ingredients in Ketoprofen Dermal Patches Characterized by Pharmaceutical Evaluation (2018)

The molecular states of ketoprofen and the interaction between ketoprofen and other pharmaceutical excipients in the matrix layer were examined to determine their effect on the pharmaceutical properties of original and generic ketoprofen dermal patches (generic patches A and B). Molecular states of ketoprofen were evaluated using polarized light microscopy, Raman spectroscopy and powder X-ray diffraction. For the original ketoprofen patch, crystalline components were not observed in the matrix layer. However, crystalline ketoprofen was observed in the two generic ketoprofen patches. Moreover, the ketoprofen exhibited hydrogen bonding with the pharmaceutical excipients or patch materials in the generic products. Skin permeation of ketoprofen from the patches was evaluated using hairless mouse skin. Twelve hours after application, the original patch demonstrated the highest level of cumulative skin permeation of ketoprofen. This was followed by generic patch B while generic patch A showed the lowest level of permeation. Fluxes were calculated from the skin permeation profiles. The original patch was approx. 2.4-times faster compared with generic patch A and approximately 1.9-times faster compared with generic patch B. This investigation suggested that pharmaceutical properties such as skin permeability for these types of products are affected by the precipitation of crystalline ketoprofen in the matrix layer and the interaction of ketoprofen with the pharmaceutical excipients or patch materials.
The inner workings of the AMPA receptors. (2002)

As with all ligand-gated ion channels, ionotropic glutamate receptors (iGluRs) convert the free energy of agonist-binding into a sequence of conformational changes that allow regulated ion flux across an otherwise insulating membrane bilayer. In the case of iGluRs, the resulting membrane depolarization is a key mediator of intercellular signals in the synapses of the CNS. Recent biomedical and structural research has greatly expanded our understanding of the chemistry of iGluR agonist binding, and of the subsequent molecular changes that drive channel gating and desensitization.
Diversity among Field Populations of Bradyrhizobium japonicum in Poland (1995)

Genetic structure in field populations of Bradyrhizobium japonicum isolated in Poland was determined by using several complementary techniques. Of the 10 field sites examined, only 4 contained populations of indigenous B. japonicum strains. The Polish bradyrhizobia were divided into at least two major groups on the basis of protein profiles on polyacrylamide gels, serological reaction with polyclonal antisera, repetitive extragenic palindromic PCR fingerprints of genomic DNA, and Southern hybridization analyses with nif and nod gene probes. Serological analyses indicated that 87.5% of the Polish B. japonicum isolates tested were in serogroups 123 and 129, while seven (12.5%) of the isolates tested belonged to their own unique serogroup. These seven strains also could be grouped together on the basis of repetitive extragenic palindromic PCR fingerprints, protein profiles, and Southern hybridization analyses. Cluster analyses indicated that the seven serologically undefined isolates were genetically dissimilar from the majority of the Polish B. japonicum strains. Moreover, immuno-cross-adsorption studies indicated that although the Polish B. japonicum strains reacted with polyclonal antisera prepared against strain USDA123, the majority failed to react with serogroup 123- and 129-specific antisera, suggesting that Polish bradyrhizobia comprise a unique group of root nodule bacteria which have only a few antigens in common with strains USDA123 and USDA129. Nodulation studies indicated that members of the serologically distinct group were very competitive for nodulation of Glycine max cv. Nawiko. None of the Polish serogroup 123 or 129 isolates were restricted for nodulation by USDA123- and USDA129-restricting soybean plant introduction genotypes. Taken together, our results indicate that while genetically diverse B. japonicum strains were isolated from some Polish soils, the majority of field sites contained no soybean-nodulating bacteria. In addition, despite the lack of long-term soybean production in Poland, field populations of unique B. japonicum strains are present in some Polish soils and these strains are very competitive for nodulation of currently used Polish soybean varieties.
The performance of Bi-Sr-Ca-Cu-O superconducting quadrupole coils (1999)

A small saddle coil for quadrupole magnets was made in industry from BSCCO-2223 high temperature superconducting tape. The coil was made to help develop methods for winding the ends of small-aperture magnets. This coil has a radius of 35 mm. It was tested in liquid helium, and liquid nitrogen. Voltage taps have been installed so that V-I characteristics of both straight and curved elements can be examined. The performance of the coil is compared to short sample measurements of pieces of conductor taken from the start and finish of the windings.
Ions in solutions: Determining their polarizabilities from first-principles (2011)

Dipole polarizabilities of a series of ions in aqueous solutions are computed from first-principles. The procedure is based on the study of the linear response of the maximally localized Wannier functions to an applied external field, within density functional theory. For most monoatomic cations (Li(+), Na(+), K(+), Rb(+), Mg(2+), Ca(2+) and Sr(2+)) the computed polarizabilities are the same as in the gas phase. For Cs(+) and a series of anions (F(-), Cl(-), Br(-) and I(-)), environmental effects are observed, which reduce the polarizabilities in aqueous solutions with respect to their gas phase values. The polarizabilities of H((aq)) (+), OH((aq)) (-) have also been determined along an ab initio molecular dynamics simulation. We observe that the polarizability of a molecule instantaneously switches upon proton transfer events. Finally, we also computed the polarizability tensor in the case of a strongly anisotropic molecular ion, UO(2) (2+). The results of these calculations will be useful in building interaction potentials that include polarization effects.
Structure of the NDH-2 – HQNO inhibited complex provides molecular insight into quinone-binding site inhibitors (2018)

Type II NADH:quinone oxidoreductase (NDH-2) is a proposed drug-target of major pathogenic microorganisms such as Mycobacterium tuberculosis and Plasmodium falciparum. Many NDH-2 inhibitors have been identified, but rational drug development is impeded by the lack of information regarding their mode of action and associated inhibitor-bound NDH-2 structure. We have determined the crystal structure of NDH-2 complexed with a quinolone inhibitor 2-heptyl-4-hydroxyquinoline-N-oxide (HQNO). HQNO is nested into the slot-shaped tunnel of the Q-site, in which the quinone-head group is clamped by Q317 and I379 residues, and hydrogen-bonds to FAD. The interaction of HQNO with bacterial NDH-2 is very similar to the native substrate ubiquinone (UQ<sub>1</sub>) interactions in the yeast Ndi1-UQ<sub>1</sub> complex structure, suggesting a conserved mechanism for quinone binding. Further, the structural analysis provided insight how modifications of quinolone scaffolds improve potency (e.g. quinolinyl pyrimidine derivatives) and suggests unexplored target space for the rational design of new NDH-2 inhibitors.
Premixed calcium–phosphate cement pastes (2003)

A self-hardening calcium-phosphate cement (CPC) containing Ca(4)(PO(4))(2)O and CaHPO(4) has been shown in clinical studies to be efficacious for repairing bone defects. This and several other similar CPCs harden in 10 min with the use of a phosphate solution as the liquid and form hydroxyapatite (HA) as the product. The present study investigated the properties of water-free, glycerol-containing CPC pastes that are stable in the package and would harden only after being delivered to a defect site where glycerol-tissue fluids exchange occurs. Premixed CPC pastes were prepared by combining cement liquids containing glycerol and various amounts of hydroxypropyl methylcellulose/Na(2)HPO(4), with CPC powders that contained (1) Ca(4)(PO(4))(2)O and CaHPO(4), (2) alpha-Ca(3)(PO(4))(2) and CaCO(3), or (3) CaHPO(4) and Ca(OH)(2). The hardening times and 1-d and 7-d diametral tensile strengths were measured on samples that hardened in an in vitro model that allowed exchange of glycerol and physiologic-like solution (PLS) through fritted glass slides at 37 degrees C. All pastes had excellent washout resistance; they remained intact and hardened while immersed in PLS and formed HA as products. Newman-Keuls multiple comparison tests indicated that the Na(2)HPO(4) amount, not the hydroxypropyl methylcellulose (HMC) amount, significantly (p < 0.05) affected the strength and hardening time. Although the premixed CPCs generally have longer hardening times and lower strengths, these pastes have excellent washout resistance before hardening and can be prepared in advance under well-controlled conditions.
Portable AC current source (2009)

Two versions of a portable AC current source with the frequency of the power network are presented. The output current is adjustable in steps from hundreds of mA up to 60 A. Fine current adjustment inside every step is also possible. The phase shift of the output current −60°, 0° and +60° is selectable. Equations for the calculations of the necessary elements to set the desired phase shift have been derived. Some measured results of a constructed sample to be manufactured are also given. The current source is intended to be used for on-site electricity meters accuracy testing without the necessity to bring them into the test laboratory.
Agreement between two large pan-cancer CRISPR-Cas9 gene dependency datasets (2019)

Abstract Genome-scale CRISPR-Cas9 viability screens performed in cancer cell lines provide a systematic approach to identify cancer dependencies and new therapeutic targets. As multiple large-scale screens become available, a formal assessment of the reproducibility of these experiments becomes necessary. We analyzed data from recently published pan-cancer CRISPR-Cas9 screens performed at the Broad and Sanger institutes. Despite significant differences in experimental protocols and reagents, we found that the screen results are highly concordant across multiple metrics with both common and specific dependencies jointly identified across the two studies. Furthermore, robust biomarkers of gene dependency found in one dataset are recovered in the other. Through further analysis and replication experiments at each institute, we found that batch effects are driven principally by two key experimental parameters: the reagent library and the assay length. These results indicate that the Broad and Sanger CRISPR-Cas9 viability screens yield robust and reproducible findings.
The edge-to-edge technique as a trick to rescue an imperfect mitral valve repair (2002)

The E-to-E technique is a simple, rapid, effective, and durable option to reduce residual MI and rescue an imperfect conventional MVR.
Surveillance of the endometrium in tamoxifen treated women (2000)

There is much debate about the risks and benefits of tamoxifen, most specifically about the incidence of associated endometrial cancer. Nearly all of the published trials on the subject have been criticized for methodological flaws and various forms of bias, making resolution of this controversy difficult. There is a consensus, however, that tamoxifen results in an increased incidence of both premalignant and malignant lesions of the endometrium. As the indications for tamoxifen continue to broaden, a larger number of women will be subjected to the potential adverse effects of tamoxifen. Many techniques for screening patients on tamoxifen for the development of endometrial abnormalities have been suggested. None of these methods appears to be consistently clinically or cost effective. We have reviewed the literature on endometrial surveillance in tamoxifen treated women with a focus on the larger publications reported within the past year. From this, we have provided what we hope to be safe and cost-effective recommendations for the management of these patients.
Endoscopically Assisted Decompression for Metastatic Thoracic Neoplasms (1998)

Endoscopically assisted decompression can reduce morbidity, hospital stay, and treatment costs while matching the efficacy of traditional combined procedures. Endoscopy provides a readily available and easily applied tool that dramatically improves the surgeon's vision, providing light, magnification, and a direct view of remote structures.
Supplementary Methods and Figure Legends 1-2 from RETRACTED: A New Class of Quinoline-Based DNA Hypomethylating Agents Reactivates Tumor Suppressor Genes by Blocking DNA Methyltransferase 1 Activity and Inducing Its Degradation (2023)

Supplementary Methods and Figure Legends 1-2 from RETRACTED: A New Class of Quinoline-Based DNA Hypomethylating Agents Reactivates Tumor Suppressor Genes by Blocking DNA Methyltransferase 1 Activity and Inducing Its Degradation
The Role of Interleukin-1 Receptor-Associated Kinases in Vogt-Koyanagi-Harada Disease (2014)

High mRNA levels of IRAK1 and IRAK4 correlated with VKH disease activity. IRAK1 and IRAK4 play a role in the activation and proliferation of CD4(+)T cells and the higher expression observed in VKH may contribute to the pathogenesis of this blinding condition.
Poly(amide-imide) materials for transparent and flexible displays (2018)

The key component currently missing for the next generation of transparent and flexible displays is a high-performance polymer material that is flexible, while showing optical and thermal properties of glass. It must be transparent to visible light and show a low coefficient of thermal expansion (CTE). While specialty plastics such as aromatic polyimides are promising, reducing their CTE and improving transparency simultaneously proved challenging, with increasing coloration the main problem to be resolved. We report a new poly(amide-imide) material that is flexible and displays glass-like behavior with a CTE value of 4 parts per million/°C. This novel polymer was successfully used as a substrate to fabricate transparent and flexible indium-gallium-zinc oxide thin-film transistors.
Identification of glycoprotein Ib beta as one of the major proteins phosphorylated during exposure of intact platelets to agents that activate cyclic AMP-dependent protein kinase. (1987)

Platelet function is inhibited by prostaglandin E1, prostaglandin I2, or forskolin, agents that increase the intracellular concentration of cyclic AMP. The inhibition appears to result from cyclic AMP-stimulated phosphorylation of specific intracellular proteins. One of the major increases in phosphorylation occurs in a polypeptide of Mr = 24,000 (P24). In this study, an effort was made to identify P24. Platelets prelabeled with [32P]phosphate were incubated with prostaglandin E1, prostaglandin I2, or forskolin. Proteins that became phosphorylated were detected by autoradiography of sodium dodecyl sulfate-polyacrylamide gels. Several lines of evidence indicated that P24 was the beta-subunit of the plasma membrane glycoprotein (GP) Ib, a glycoprotein that is essential for the adhesion of platelets to damaged subendothelium, for the rapid response of platelets to thrombin, and for the attachment of the membrane skeleton to the cytoplasmic face of the plasma membrane. P24 co-migrated with GP Ib beta on reduced gels (Mr = 24,000) and also on nonreduced gels (when GP Ib beta is disulfide-linked to GP Ib alpha and migrates with Mr = 170,000). Like GP Ib beta, P24 was associated with actin filaments in Triton X-100 lysates. Like GP Ib beta, it was selectively associated with filaments of the membrane skeleton and was released from filaments when the Ca2+-dependent protease was active. Antibodies against GP Ib immunoprecipitated P24 from platelet lysates. Finally, exposure of Bernard-Soulier platelets (which lack GP Ib) to prostaglandin E1 resulted in phosphorylation of other polypeptides, but not of P24. These studies show that P24, one of the major polypeptides phosphorylated when platelets are exposed to agents that inhibit platelet function by increasing the concentration of cyclic AMP, is the beta-subunit of GP Ib.
Grafting of a Eu3+-tfac complex on to a Tb3+-metal organic framework for use as a ratiometric thermometer (2017)

Microrods of [Tb<sub>2</sub>(bpydc)<sub>3</sub>(H<sub>2</sub>O)<sub>3</sub>]·nDMF (TbMOF) were employed as a platform for grafting a β-diketonate complex of Eu<sup>3+</sup> for the purpose of obtaining ratiometric luminescence thermometer materials. A straightforward post-synthetic functionalization is employed to obtain the TbMOF@Eu_tfac (tfac = trifluoroacetylacetonate) compounds. The emission color of the TbMOF@Eu compounds can be slightly tuned by varying the percentage of the grafted β-diketonate complex of Eu<sup>3+</sup>. Also, as shown, the thermometric properties of the material can be tuned by the percentage of grafted β-diketonate complex of Eu<sup>3+</sup>. The TbMOF@3%Eu_tfac and TbMOF@7.3%Eu_tfac compounds were investigated in detail for their use as luminescent ratiometric thermometers. For the TbMOF@3%Eu_tfac compound an absolute sensitivity S<sub>a</sub> of 0.069 K<sup>-1</sup> (225 K) and relative sensitivity S<sub>r</sub> of 2.59%K<sup>-1</sup> (225 K) were obtained showing its good sensing capability. For the TbMOF@7.3%Eu_tfac compound a S<sub>a</sub> of 0.012 K<sup>-1</sup> (275 K) and relative sensitivity S<sub>r</sub> of 1.33%K<sup>-1</sup> (325 K) were obtained showing that the TbMOF@3%Eu_tfac compound is superior for temperature sensor applications. We also show that the emission color of the parent TbMOF material itself can be tuned by varying the excitation wavelength from 250-380 nm. It can be tuned from light-green to blue by simply changing the excitation wavelength.
An extension of the relational data model to incorporate ordered domains (2001)

We extend the relational data model to incorporate partial orderings into data domains, which we call the ordered relational model. Within the extended model, we define the partially ordered relational algebra (the PORA) by allowing the ordering predicate ⊑ to be used in formulae of the selection operator (σ). The PORA expresses exactly the set of all possible relations that are invariant under order-preserving automorphism of databases. This result characterizes the expressiveness of the PORA and justifies the development of Ordered SQL (OSQL) as a query language for ordered databases. OSQL provides users with the capability of capturing the semantics of ordered data in many advanced applications, such as those having temporal or incomplete information. Ordered functional dependencies (OFDs) on ordered databases are studied, based on two possible extensions of domain orderings: pointwise ordering and lexicographical ordering. We present a sound and complete axiom system for OFDs in the first case and establish a set of sound and complete chase rules for OFDs in the second. Our results suggest that the implication problems for both cases of OFDs are decidable and that the enforcement of OFDs in ordered relations are practically feasible. In a wider perspective, the proposed model explores an important area of object-relational databases, since ordered domains can be viewed as a general kind of data type.
Understanding Photovoltage in Insulator-Protected Water-Splitting Half-Cells (2015)

In the pursuit of a photosynthetic and efficient water splitting device, efforts have focused on optimizing specific aspects of the whole: catalysis, electronic conductivity, cathode and anode stability, and kinetics among other aspects. Improvement in one aspect can, however, often require fundamental tradeoffs affecting others. The photovoltage required to achieve a current density of interest for a water splitting device is an especially important metric. High solar-to-hydrogen efficiency is the ultimate goal of water splitting research, but reporting efficiency in a half cell can be misleading. This report investigates the photovoltage in insulator-protected water splitting cells using ALD-TiO 2 protected silicon anodes as a case study and looks in depth at how it is correctly determined from typical electrochemical analysis and how this relates to the underlying solid-state carrier transport. Finally, the photovoltage at 10 mA/cm 2 operating current referenced to the thermodynamic potentials is reviewed from several leading research reports, allowing for a direct comparison of cell performance.