gebhart/patrepeval huggingface dataset:
Computerized medication monitoring system (1976)

A computerized medication monitoring system for alerting and warning of potential adverse drug reactions is described. The system integrates computerized data on each hospital patient (medications, clinical laboratory, blood gas, ECG, ALLERGIES, DIAGNOSIs, etc.) and returns to the pharmacist warning messages and suggestions regarding patient drug therapy. The broad data base allows for nearly complete drug therapy monitoring. When a warning message is received, the pharmacist contacts the physician or nursing staff and explains the potential problem. The system also generates prescription labels and patient drug profiles which are used in a unit dose dispensing system. Five percent of 13,727 patients monitored have had drug alerts. Of these alterts, 44.9% were drug-laboratory contraindications and only 28.9% were drug-drug interactions. Of the 690 alerts received, 77% resulted in the physician changing the patient's therapy.
C++ the Core Language (1995)

Preface Chapter 1. Object-Oriented Programming with Classes Object-Oriented Programming Classes Chapter 2. C++ Without Classes Three to Start Function Changes Stricter Typing Dynamic Initialization of Globals Some Final Lists Chapter 3. Abstraction with Member Functions The Abstraction Using a struct Using a struct with Interface Functions Using a Class with Member Functions Chapter 4. Encapsulation with Access Specifiers Access Specifiers A Member Can Have Any Access Level Unlimited Access Specifiers Private Does Not Mean Invisible Friend Classes Chapter 5. Hierarchy with Composition and Derivation Composition Derivation Chaining Chapter 6. Better Abstraction with Constructors and Destructors The Default Constructor The Destructor Built-in Types Hierarchy and Chaining Implicit Default Constructors and Destructors Beyond Chaining Explicit Invocation Flow of Control Time of Invocation Chapter 7. Better Abstraction with new and delete Dynamic Objects Dynamic Arrays Mixing Allocators realloc() Out of Memory Chapter 8. References Parameter Versus Argument Passing by Value in C and C++ Passing by Reference in C++ Reference Versus Pointer Returning by Reference in C++ Overloading: Reference Versus Value Binding Problems Chapter 9. Better Abstraction with Other Special Member Functions Assignment Operator Copy Constructor Printing an Object Summary Chapter 10. An Example Class Using an int Using a Static Array Using a Dynamic Array Using a Reference-Counted String Copy Constructor Quiz Summary Table Chapter 11. Better Hierarchy with Templates Defining a Template Using a Template to Define an Object Careful with That Expansion, Eugene Modifying Container Class Elements Chapter 12. Polymorphism with Virtual Functions Polymorphism in C Virtual Functions Polymorphism in C++ More About Virtual Functions Chapter 13. More About Polymorphism Abstract Classes Derivation Decisions Virtual Decisions Calling Virtual Functions from Constructors and Destructors Under the Hood Pitfalls Chapter 14. Implementing an Object-Oriented Design Implementation Table Examples Is-A, Has-A Defensive Implementation Chapter 15. An Example Program The String Class The Rule, CwRule, and HwRule Classes The Scanner Class Using the Program Example Code Chapter 16. What to Study Next const inline Constructors with Parameters Member Initialization Lists Efficient Copy Constructor Special Member Functions Appendix A. C++ Operators Appendix B. One Problem with Returning by Value Glossary Index
The Phage Infection Process: a Functional Role for the Distal Linker Region of Bacteriophage Protein 3 (2000)

The filamentous bacteriophage infects Escherichia coli by interaction with the F pilus and the TolQRA complex. The virus-encoded protein initiating this process is the gene 3 protein (g3p). The g3p molecule can be divided into three different domains separated by two glycine-rich linker regions. Though there has been extensive evaluation of the importance of the diverse domains of g3p, no proper function has so far been assigned to these linker regions. Through the design of mutated variants of g3p that were displayed on the surface of bacteriophage, we were able to elucidate a possible role for the distal glycine-rich linker region. A phage that displayed a g3p comprised of only the N1 domain, the first linker region, and the C-terminal domain was able to infect cells at almost the same frequency as the wild-type phage. This infection was proven to be dependent on the motif between amino acid residues 68 and 86 (i.e., the first glycine-rich linker region of g3p) and on F-pilus expression.
Hemodynamics in the pulmonary artery of a patient with pneumothorax (2011)

Pneumothorax is characterized by lung collapse and an alteration of lung geometry, resulting in alterations of the pulmonary artery blood flow. Though many clinical studies and animal experiments have investigated the effects of pneumothorax on the hemodynamics of pulmonary arteries, its precise effects remain unclear. In this patient-specific study, we investigated the effects of lung deformation and vascular resistance increases due to pneumothorax on the pulmonary blood flow during the acute phase and after recovery. Arterial geometry was extracted up to the fifth generation from computed tomography images, and reconstructed. Computational fluid dynamic analysis was performed, for an unsteady laminar flow with resistance at the outlets, in a reconstructed domain. The results demonstrated a change in flow structure during systole between the acute phase and recovery, and were associated with variations in the flow rate ratio between the right and left lungs. We observed a parabolic-like decrease of the volume flow rate ratio in the affected lung as the resistance increased. Thus, the systemic artery blood oxygenation will rely more on the unaffected lung leading to improved oxygenation of the blood under high resistance in the affected lung. These findings are significant in our understanding of ventilation function under a pneumothorax.
ChemInform Abstract: Preparation and Electrocyclic Ring‐Opening of Cyclobutenes: Stereocontrolled Approaches to Substituted Conjugated Dienes and Trienes. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Time-dependent density-matrix renormalization-group using adaptive effective Hilbertspaces (2004)

An algorithm for the simulation of the evolution of slightly entangled quantum states has been recently proposed as a tool to study time-dependent phenomena in one-dimensional quantum systems. Its key feature is a time-evolving block-decimation (TEBD) procedure to identify and dynamically update the relevant, conveniently small, subregion of the otherwise exponentially large Hilbert space. Potential applications of the TEBD algorithm are the simulation of time-dependent Hamiltonians, transport in quantum systems far from equilibrium and dissipative quantum mechanics. In this paper we translate the TEBD algorithm into the language of matrix product states in order to both highlight and exploit its resemblances to the widely used density-matrix renormalization-group (DMRG) algorithms. The TEBD algorithm, being based on updating a matrix product state in time, is very accessible to the DMRG community and it can be enhanced by using well-known DMRG techniques, for instance in the event of good quantum numbers. More importantly, we show how it can be simply incorporated into existing DMRG implementations to produce a remarkably effective and versatile ‘adaptive time-dependent DMRG’ variant, that we also test and compare to previous proposals.
The antimicrobial peptide LL‐37 modulates the inflammatory and host defense response of human neutrophils (2010)

The human cathelicidin antimicrobial peptide acts as an effector molecule of the innate immune system with direct antimicrobial and immunomodulatory effects. The aim of this study was to test whether the cathelicidin LL-37 modulates the response of neutrophils to microbial stimulation. Human neutrophils were exposed to LPS, Staphylococcus aureus and Pseudomonas aeruginosa subsequent to incubation with LL-37 and cytokine release was measured by ELISA. The incubation with LL-37 significantly decreased the release of proinflammatory cytokines from stimulated human neutrophils. ROS production of neutrophils was determined by a luminometric and a flow cytometry method. The peptide induced the production of ROS and the engulfment of bacteria into neutrophils. Peritoneal mouse neutrophils isolated from CRAMP-deficient and WT animals were treated with LPS and TNF-alpha in the supernatant was measured by ELISA. Antimicrobial activity of neutrophils was detected by incubating neutrophils isolated from CRAMP-knockout and WT mice with bacteria. Neutrophils from CRAMP-deficient mice released significantly more TNF-alpha after bacterial stimulation and showed decreased antimicrobial activity as compared to cells from WT animals. In conclusion, LL-37 modulates the response of neutrophils to bacterial activation. Cathelicidin controls the release of inflammatory mediators while increasing antimicrobial activity of neutrophils.
The role of anchor residues in the binding of peptides to HLA‐A*1101 molecules (1998)

The binding of 136 8- to 12-mer peptides carrying anchor residues at position 2 (P2) and the C-terminus to HLA-A*1101 molecules was analyzed by a stabilization assay using RMA-S transfectants expressing HLA-A*1101 and human beta2-microglobulin. 72.1% of these peptides bound to HLA-A*1101 molecules. Two known HLA-All-restricted cytotoxic T-lymphocyte epitope peptides showed high affinity to HLA-A*1101. The results confirmed a previous pool sequencing study of HLA-A*1101 binding self-peptides, which showed that Lys at the C-terminus and Val, Ile, Phe, Tyr, and Thr at P2 are anchor residues for HLA-A*1101. Thr and aliphatic hydrophobic residues Val, Ile, and Leu at P2 are stronger anchor residues than the aromatic hydrophobic residues Phe and Tyr. In addition, hydrophobic residues Leu, Phe, Tyr, Ile, and Ala at position 3 (P3) are secondary anchors but are weaker than those at P2. The affinities of the 8- and 12-mer peptides were significantly lower than those of 9- to 11-mer peptides. There was however no difference in affinity between 9-, 10- and 11-mer peptides. Furthermore, the analysis using peptides mutated at the C-terminus showed that HLA-A*1101 molecules can bind peptides carrying another positively charged residue, Arg. The present study clarified the role of the anchor residues at P2, P3 and the C-terminus in the binding of HLA-A*1101 molecules.
Stereoselective Synthesis of Brevianamide E (2011)

The hydroxypyrroloindolenine (Hpi) motif forms the fundamental core of the pentacyclic natural product, brevianamide E, the concise stereoselective synthesis of which, via oxidative cyclization, is described.
THE DISAPPEARANCE OF HUMAN CHORIONIC GONADOTROPIN FROM PLASMA AND URINE FOLLOWING INDUCED ABORTION (1985)

In 28 females, daily measurement of the HCG concentration in urine and in 15 of them daily measurement of the beta-HCG concentration in plasma was carried out during the first 2 weeks following first-trimester induced abortion by vacuum aspiration. Plasma beta-HCG concentration fell according to a multi-exponential curve with a half-life of 0.63 days in the first 2 days following induced abortion, and of 3.85 days in the subsequent 14 days. The disappearance of HCG from urine is exponential, with a half-life value of 1.3 days. A urine pregnancy test with a sensitivity of 1 IU/ml wil nearly always be negative in the course of 2 weeks after abortion. A positive test 4 weeks after abortion indicates an incomplete abortion or persistent trophoblast.
Hypoxia Increases Tumor Cell Shedding of MHC Class I Chain-Related Molecule: Role of Nitric Oxide (2008)

The MHC class I chain-related (MIC) molecules play important roles in tumor immune surveillance through their interaction with the NKG2D receptor on natural killer and cytotoxic T cells. Thus, shedding of the MIC molecules from the tumor cell membrane represents a potential mechanism of escape from NKG2D-mediated immune surveillance. Tumor hypoxia is associated with a poor clinical outcome for cancer patients. We show that hypoxia contributes to tumor cell shedding of MIC through a mechanism involving impaired nitric oxide (NO) signaling. Whereas hypoxia increased MIC shedding in human prostate cancer cells, activation of NO signaling inhibited hypoxia-mediated MIC shedding. Similar to incubation in hypoxia, pharmacologic inhibition of endogenous NO signaling increased MIC shedding. Parallel studies showed hypoxia-mediated tumor cell resistance to lysis by interleukin 2-activated peripheral blood lymphocytes (PBL) and NO-mediated attenuation of this resistance to lysis. Inhibition of NO production also led to resistance to PBL-mediated lysis. Interference of MIC-NKG2D interaction with a blocking anti-MIC antibody abrogated the effect of hypoxia and NO signaling on tumor cell sensitivity to PBL-mediated lysis. Finally, continuous transdermal delivery of the NO mimetic glyceryl trinitrate (7.3 mug/h) attenuated the growth of xenografted MIC-expressing human prostate tumors. These findings suggest that the hypoxic tumor microenvironment contributes to resistance to immune surveillance and that activation of NO signaling is of potential use in cancer immunotherapy.
Physical properties of surface-barrier structure with microrelief semiconductor-metal interface (2002)

The present report deals with experimental investigations of optical, electric and photoelectric properties of microrelief surfaces of III-V semiconductors and surfacer-barrier structures prepared on the basis of metal-semiconductor interfaces (Au-GaAs; Au, Ag-InP). The surface plasmon polariton excitation was shown to be an additional mechanism of the photosensitivity enhancement.
Effect of Microbial Heat Shock Proteins on Airway Inflammation and Hyperresponsiveness (2002)

Microbial heat shock proteins (hsp) have been associated with the generation and induction of Th1-type immune responses. We tested the effects of treatment with five different microbial hsp (Mycobacterium leprae, Streptococcus pneumoniae, Helicobacter pylori, bacillus Calmette-Guérin, and Mycobacterium tuberculosis) in a murine model of allergic airway inflammation and airway hyperresponsiveness (AHR). Mice were sensitized to OVA by i.p. injection and then challenged by OVA inhalation. Hsp were administered to each group by i.p. injection before sensitization and challenge. Sensitized and challenged mice developed increased serum levels of OVA-specific IgE with significant airway eosinophilia and heightened responsiveness to methacholine when compared with nonsensitized animals. Administration of M. leprae hsp prevented both development of AHR as well as bronchoalveolar lavage fluid eosinophilia in a dose-dependent manner. Treatment with M. leprae hsp also resulted in suppression of IL-4 and IL-5 production in bronchoalveolar lavage fluid, while IL-10 and IFN-gamma production were increased. Furthermore, M. leprae hsp treatment significantly suppressed OVA-specific IgE production and goblet cell hyperplasia/mucin hyperproduction. In contrast, treatment with the other hsp failed to prevent changes in airway responsiveness, lung eosinophilia, or cytokine production. Depletion of gamma/delta T lymphocytes before sensitization and challenge abolished the effect of M. leprae hsp treatment on AHR. These results indicate selective and distinctive properties among the hsp, and that M. leprae hsp may have a potential therapeutic role in the treatment of allergic airway inflammation and altered airway function.
A Diversity-Promoting Objective Function for Neural Conversation Models (2015)

Sequence-to-sequence neural network models for generation of conversational responses tend to generate safe, commonplace responses (e.g., "I don't know") regardless of the input. We suggest that the traditional objective function, i.e., the likelihood of output (response) given input (message) is unsuited to response generation tasks. Instead we propose using Maximum Mutual Information (MMI) as the objective function in neural models. Experimental results demonstrate that the proposed MMI models produce more diverse, interesting, and appropriate responses, yielding substantive gains in BLEU scores on two conversational datasets and in human evaluations.
Multigrid methods for classical molecular dynamics simulations of biomolecules (2001)

We present an O(N) multigrid-based method for the efficient calculation of the long-range electrostatic forces needed for biomolecular simulations, that is suitable for implementation on massively parallel architectures. Along general lines, the method consists of: (i) a charge assignment scheme, which both interpolates and smoothly assigns the charges onto a grid; (ii) the solution of Poisson’s equation on the grid via multigrid methods; and (iii) the back interpolation of the forces and energy from the grid to the particle space. Careful approaches for the charge assignment and the force interpolation, and a Hermitian approximation of Poisson’s equation on the grid allow for the generation of the high-accuracy solutions required for high-quality molecular dynamics simulations. Parallel versions of the method scale linearly with the number of particles for a fixed number of processors, and with the number of processors, for a fixed number of particles.
Nanodiamonds Produced from Low-Grade Indian Coals (2017)

Coal is considered to be an abundantly available cheap feedstock for the fabrication of carbon nanomaterials. In this Letter, a report on the formation of nanodiamond from low-grade coals during low-power ultrasonic-assisted stimulation in hydrogen peroxide (H2O2) followed by dialysis in 1 kDa is given. High resolution-transmission electron microscopy (HR-TEM), X-ray diffraction (XRD), Raman spectroscopy, ultraviolet–visible spectroscopy (UV–vis), fluorescence (FL), and Fourier transform infrared (FT-IR) spectroscopy analyses revealed the formation of carbon nanocrystals of monocrystalline and polycrystalline form with multiple plans. The nominal size of the carbon nanocrystals are found to be in the range of 4–15 nm. The planar spacing of the crystal lattice fingers is in the range of 2.0–2.3 Å and are in good agreement with the lattice planes of various diamond phases including cubic diamond and lonsdaleite. The present work significantly contributes an additional synthetic methodology of nanodiamond production by using the cheap low-grade coal feedstock. The nanodiamond formed shows bright blue fluorescence under UV-light with excitation dependent and holding promising application in bioimaging engineering, photovoltaics, and optoelectronics.
Interaction and solubilization of some phenolic antioxidants in Pluronic® micelles B Biointerfaces (2011)

The solubilization of four phenolic antioxidants, namely p-hydroxybenzoic acid (PHBAA), syringic acid, sinapic acid, and quercetin in micelles of an ethylene oxide (EO)–propylene oxide (PO) triblock copolymer Pluronic® P104 (EO₂₇–PO₆₁–EO₂₇, PPO mol wt=3540, % PEO=40) was examined at different temperatures, pHs, and in the presence of sodium chloride. The nano-size core–shell micelles of P104 characterized by dynamic light scattering had hydrodynamic diameter of about 18–20nm with low polydispersity. Antioxidants induced micellization and micellar growth were observed. The critical micellar concentration (CMC), critical micellar temperature (CMT), cloud point (CP) of P104 decreased due to solubilization and interactions of antioxidants. The solubilization was favored at higher temperature, pH and in the presence of salt and follows the order PHBA>syringic acid>sinapic acid>quercetin which corresponds to the trend in their aqueous solubility. The location of antioxidant in micelles observed from NOESY spectra. Structure and hydrophobicity of antioxidants were found to be governing factors for their interaction and location in the micelles.
The spectrum of the Poincar{é} operator in an ellipsoid (2023)

We study the spectrum of the Poincaré operator in triaxial ellipsoids subject to a constant rotation. As explained in the paper, this mathematical problem is interesting for many physical applications. It is known that the spectrum of this bounded self-adjoint operator is pure point with polynomial eigenvectors [Backus &amp; Rieutord, Phys. Rev. E 95 (2017), 053116]. We give two new proofs of this result. Moreover, we describe the large-degree asymptotics of the restriction of that operator to polynomial vector fields of fixed degrees. The main tool is the microlocal analysis of the partial differential equation satisfied by the orthogonal polynomials in ellipsoids. This work also contains numerical calculations of these spectra, showing a very good agreement with the mathematical results.
Integration of Fuzzy Logic Techniques into DSS for Profitability Quantification in a Manufacturing Environment (2012)

Production control, planning, and scheduling are forms of decision making, which play a crucial role in manufacturing industries. In the current competitive environment, effective decision-making has become a necessity for survival in the marketplace. This chapter provides insight into the issues relating to integration of fuzzy logic techniques into decision support systems for profitability quantification in a manufacturing environment. The chapter is divided into five sections with a general introduction of the topic, followed by a thorough literature review on the existing techniques. Thereafter, fuzzy logic algorithms using logistic membership functions and resource variables for decision making aiming at quality improvement are discussed. A case study involving a textile firm is then described with the computational results and findings, and finally, future research directions are presented.
Structure and antigenicity of the major specific glycolipid antigen of Mycobacterium leprae. (1982)

Earlier we reported on the presence of a specific phenolic glycolipid (Phenolic Glycolipid-I) in Mycobacterium leprae, and in infected armadillo tissues (Hunter, S. W., and Brennan, P. J. (1981) J. Bacteriol. 147, 728-735). It had an inherent oligosaccharide, composed of 3-O-Me-rhamnose, 2,3-di-O-Me-rhamnose, and 3,6-di-O-Me-glucose, glycosidically linked to the phenol substituent. The structure of the oligosaccharide has now been determined, by partial acid hydrolysis, permethylation, 1H NMR, and 13C NMR as: 3,6-di-O-Me-Glcp(1 beta leads to 4)2,3-di-O-Me-Rhap(1 alpha leads to 2)3-O-Me-Rhap1 alpha leads to phenol (assuming that the glucose substituent is in the D-enantiomeric configuration, and the two methylated rhamnoses are L). Acid hydrolysis of deacylated Phenolic glycolipid-I yielded a phenolic phthiocerol "core," and mass spectrometry and proton NMR of the permethylated core suggested the following structure: (formula, see text) Combined gas-liquid chromatography-mass spectrometry showed three tetramethyl branched "mycocerosic" acids, C30, C32 and C34, with molecular weights (as methyl esters) of 466, 494, and 522, respectively. These are esterified to the hydroxyl functions of the branched glycolic chain. Evidence is also presented that the glycolipid is immunologically active, reacting with rabbit antisera to M. leprae and with sera from lepromatous leprosy patients.