gebhart/patrepeval huggingface dataset:
Association of Transcatheter Mitral Valve Repair Availability With Outcomes of Mitral Valve Surgery (2021)

Background Transcatheter mitral valve repair (TMVr) is currently offered at selected centers that meet certain operator and institutional requirements. We sought to explore the hypothesis that the availability of TMVr is associated with improved outcomes of MV surgery. Methods and Results We used the Nationwide Readmissions Database to identify patients who underwent MV surgery at centers with or without TMVr capabilities between January 1 and December 31, 2017. The primary end point was in-hospital mortality. Secondary end points were postoperative complications, resource use, and 30-day readmissions. A total of 24 477 patients from 595 centers (446 TMVr, 149 non-TMVr) were included. There were modest but statistically significant differences in the prevalence of comorbidities between the groups. Patients at non-TMVr centers had higher unadjusted in-hospital mortality than those at TMVr centers (5.6% versus 3.6%, <i>P</i><0.001). They also had higher rates of postoperative complications, longer hospitalizations, higher cost, and fewer home discharges but similar 30-day readmission rates. After propensity matching, mortality remained higher at non-TMVr centers (5.5% versus 4.0%, <i>P</i><0.001). Rates of postoperative complications, prolonged hospitalizations, and nonhome discharges also remained higher. Postoperative mortality was consistently higher at non-TMVr centers in multiple risk-adjustment analyses incrementally accounting for differences in risk factors, surgical volume, availability of surgical repair, and excluding concomitant procedures. In the most comprehensive model, surgery at non-TMVr centers was associated with higher odds of death (odds ratio, 1.41; 95% CI, 1.14-1.73; <i>P</i>=0.002). Conclusions Mitral valve surgery at TMVr centers is associated with improved in-hospital outcomes compared with non-TMVr centers.
Review of Chemistry in the Kitchen Garden (2012)

ADVERTISEMENT RETURN TO ISSUEPREVBook ReviewNEXTReview of Chemistry in the Kitchen GardenSusan M. EnselView Author Information Hood CollegeFrederick, MarylandCite this: J. Nat. Prod. 2012, 75, 12, 2271Publication Date (Web):November 26, 2012Publication History Published online26 November 2012Published inissue 28 December 2012https://pubs.acs.org/doi/10.1021/np3007952https://doi.org/10.1021/np3007952book-reviewACS PublicationsCopyright © 2012 The American Chemical Society and American Society of PharmacognosyRequest reuse permissionsArticle Views469Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Food,Metabolism,Pharmaceuticals,Plants,Soils Get e-Alerts
A custom integrated circuit comparator for high-performance sampling applications (2003)

The design and performance of an application specific integrated circuit (ASIC) comparator that has been optimized for equivalent-time waveform sampling applications is reported. The comparator, which has been fabricated with an 8.5-GHz f/sub T/, bipolar silicon process, features a bandwidth of >2 GHz, a settling-time accuracy of 0.1% in 2 ns, and almost total elimination of thermal tails in the settling response. The design has eliminated thermal effects, common in other comparators, than can cause errors and affect the voltage settling time. The comparator can be used in a sampling system for both frequency domain measurements, e.g., wideband RMS voltage measurements, and high accuracy time domain pulse measurements.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Overexpression of p53 protein in primary Ewing’s sarcoma of bone: relationship to tumour stage, response and prognosis (1999)

Biopsy tissues of 52 patients with Ewing's sarcoma of bone treated between 1983 and 1993 were examined immuno-histochemically to determine the significance of p53 protein in diagnosis and prognosis of Ewing's sarcoma. Mean age at diagnosis was 17 years (range 6-36) and minimum follow-up was 30 months. The tumours were located in the extremities and central bones in 35 and 17 patients respectively. Metastases were present in seven patients at diagnosis. Treatment consisted of chemotherapy, surgery and/or radiotherapy in all the patients. Overexpression of p53 protein was demonstrated in seven patients (14%). There was no relationship between expression of p53 and site of tumours. Patients who overexpressed p53 protein appeared to have more advanced diseases at diagnosis and poorer response to chemotherapy than those without p53 overexpression. The 5-year relapse-free survival and overall survival in patients without metastases at the time of diagnosis were 66% and 71%, respectively, in p53 protein-negative patients compared with 20% relapse-free and overall survival in those with p53 protein overexpression (P= 0.01). The poorer prognosis in p53 protein-positive patients was independent of site, local treatment or necrosis of the tumours (P < 0.05). Over-expression of p53 protein is an independent poor prognostic factor in Ewing's sarcoma of bone.
New Insights on Moojase, a Thrombin-Like Serine Protease from Bothrops moojeni Snake Venom (2018)

Snake venom serine proteases (SVSPs) are enzymes that are capable of interfering in various parts of the blood coagulation cascade, which makes them interesting candidates for the development of new therapeutic drugs. Herein, we isolated and characterized Moojase, a potent coagulant enzyme from <i>Bothrops moojeni</i> snake venom. The toxin was isolated from the crude venom using a two-step chromatographic procedure. Moojase is a glycoprotein with N-linked glycans, molecular mass of 30.3 kDa and acidic character (pI 5.80⁻6.88). Sequencing of Moojase indicated that it is an isoform of Batroxobin. Moojase was able to clot platelet-poor plasma and fibrinogen solutions in a dose-dependent manner, indicating thrombin-like properties. Moojase also rapidly induced the proteolysis of the Aα chains of human fibrinogen, followed by the degradation of the Bβ chains after extended periods of incubation, and these effects were inhibited by PMSF, SDS and DTT, but not by benzamidine or EDTA. RP-HPLC analysis of its fibrinogenolysis confirmed the main generation of fibrinopeptide A. Moojase also induced the fibrinolysis of fibrin clots formed in vitro, and the aggregation of washed platelets, as well as significant amidolytic activity on substrates for thrombin, plasma kallikrein, factor Xia, and factor XIIa. Furthermore, thermofluor analyses and the esterase activity of Moojase demonstrated its very high stability at different pH buffers and temperatures. Thus, studies such as this for Moojase should increase knowledge on SVSPs, allowing their bioprospection as valuable prototypes in the development of new drugs, or as biotechnological tools.
First clinical use of the redesigned HeartMate II left ventricular assist system in the United States: a case report. (2004)

Axial flow ventricular assist devices show great promise as a potential treatment for patients with end-stage heart failure. The HeartMate II system, redesigned on the basis of initial clinical experiences in Europe, is now in clinical trials in the United States. We report on the 1st use of the newly redesigned HeartMate II in the United States. The system has unique features, which include an accurate flow estimator and the ability to automatically detect and correct excessive left ventricular unloading. The new design also incorporates changes in the texturing of the blood-contacting surfaces to prevent thrombosis. The implantation technique and configuration are similar to those of the HeartMate XVE LVAS and require a median sternotomy for access. The 1st patient to receive the device in the United States has had an uncomplicated perioperative course and now awaits transplantation.
Molecular Crystallization Controlled by pH Regulates Mesoscopic Membrane Morphology (2012)

Coassembled molecular structures are known to exhibit a large variety of geometries and morphologies. A grand challenge of self-assembly design is to find techniques to control the crystal symmetries and overall morphologies of multicomponent systems. By mixing +3 and -1 ionic amphiphiles, we assemble crystalline ionic bilayers in a large variety of geometries that resemble polyhedral cellular crystalline shells and archaea wall envelopes. We combine TEM with SAXS and WAXS to characterize the coassembled structures from the mesoscopic to nanometer scale. The degree of ionization of the amphiphiles and their intermolecular electrostatic interactions are controlled by varying pH. At low and high pH values, we observe closed, faceted vesicles with two-dimensional hexagonal molecular arrangements, and at intermediate pH, we observe ribbons with rectangular-C packing. Furthermore, as pH increases, we observe interdigitation of the bilayer leaflets. Accurate atomistic molecular dynamics simulations explain the pH-dependent bilayer thickness changes and also reveal bilayers of hexagonally packed tails at low pH, where only a small fraction of anionic headgroups is charged. Coarse-grained simulations show that the mesoscale geometries at low pH are faceted vesicles where liquid-like edges separate flat crystalline domains. Our simulations indicate that the curved-to-polyhedral shape transition can be controlled by tuning the tail density in regions where sharp bends can form the polyhedral edges. In particular, the pH acts to control the overall morphology of the ionic bilayers by changing the local crystalline order of the amphiphile tails.
Degradation of Polychlorinated Biphenyls Induced by Ionizing Radiation in Aqueous Micellar Solutions (1998)

This investigation examines the γ-radiation-induced degradation of polychlorinated biphenyls (PCBs) in aqueous surfactant solutions. Dichloro-, tetrachloro-, and decachlorobiphenyl congeners were solubilized in water using a commercially available non-ionic surfactant, Triton X-100, and subsequently irradiated by a 60Co γ-source. Rates and extent of dechlorination were determined at different surfactant concentrations, and intermediate species and byproducts were quantified. Pulse radiolysis was used to measure rates of reaction between PCBs and the solvated electron as well as rates of electron scavenging by the surfactant. Experiments were also conducted in organic solvents, and these results have been compared to those observed in the aqueous surfactant solutions. Each PCB congener was fully dechlorinated by ionizing radiation in the micellar systems. Initial chloride yields were directly proportional to the level of chlorination of the PCB congeners. Scavenging of the aqueous electron by the surfactant was significant, and PCB degradation efficiency improved markedly at lower surfactant concentrations. PCB transformation occurred primarily through reductive dechlorination, forming lower chlorinated PCBs and biphenyl. Rates of PCB degradation were substantially higher in aqueous surfactant solutions than in diethyl ether and petroleum ether. This suggests that solubilizing PCBs in water using a surfactant prior to irradiation may provide a considerable improvement in contaminant degradation efficiency in comparison to using an organic solvent or irradiating PCBs directly in oil.
Supplementary Figure S2 from Intratumoral Heterogeneity in a <i>Trp53</i>-Null Mouse Model of Human Breast Cancer (2023)

&lt;p&gt;Supplementary Figure S2. FACS profile comparison and immunostaining on the p53 null parental tumor and the subsequent TIC- and CD29HCD24L niche subpopulation-derived tumor.&lt;/p&gt;
Four-transistor static CMOS memory cells (1977)

A new approach toward size reduction of low-power static memory cells, based on ion-implanted leaky diodes in CMOS circuits, is described. The leaky diodes act as trickle chargers counteracting normal diode leakage currents and can be used in four different cells: a one-sided cell, a two-sided cell, and their complements. The reverse conductance of the implanted diodes must be greater than that of a normal diode of opposite type, but smaller than that of a transistor. The conductance range which allows static operation is thus quite broad. Results of leakage studies for various damage implantation schedules are shown, indicating that the peripheral contribution to leakage dominates and that the leakage activation energy in an implanted device is roughly half that of an ordinary diode. These considerations, along with static power constraints, lead to a realizable range of viable enhanced leakage levels. Since leaky diodes are constructed under contact openings to diffusions, they consume no additional area in the cell. Circuit design aspects of the cell variations are discussed.
Atherosclerosis in man: natural history and effects (1972)

The term natural history is often used as an excuse for vague discursive accounts of biological matters; nothing could be less desirable in a subject like atherosclerosis
Clinical experience with an excimer laser angioplasty system (1991)

We report on a medical excimer laser system developed for laser angioplasty. One of the unique features of this excimer laser is the required low frequency of gas replenishment. Data presented, showing the time between gas changes, is approaching six months. As of December 1, 1990, more than 500 percutaneous coronary cases have been performed using this system. The catheters used for the majority of the cases are composed of 100 micron fiber bundles. The cutting depth per pulse is shown to be proportional to the catheter active area.
Poly(amide–ether) Thermoplastic Elastomers Based on Monodisperse Aromatic Amide Hard Segments as Shape-Memory and Moisture-Responsive Materials (2018)

A series of high-molecular-weight (Mn up to 29000) multiblock poly(N-methylbenzamide)-b-poly(ethylene glycol) polymers [poly(MABx–x-b-PEG)], utilizing monodisperse telechelic aromatic N-methylbenzamide-based molecules (MABx–x) (molar mass distribution Mw/Mn = 1.02–1.04) with H2N-PEG-NH2, were successfully prepared via conventional solution polycondensation; their shape-memory and moisture-responsive properties were thoroughly investigated. The resultant multiblock copolymers showed three thermal transitions: the glass transition (Tg) and melting (Tm) of the PEG segment at −35 and 55 °C, respectively, and Tg of the MABx-x segment at 215 °C. Hard opaque pale-yellow films were successfully prepared using the solution-cast method, and several films showed good shape-memory properties, i.e., a shape fixity of 91% and a shape recovery of 97%. These properties were only observed for multiblock copolymer films having both crystalline PEG (degrees of crystallinity from 34.8% to 43.7% were observed) and aggregated monodisperse MABx–x phases. The existence of this cocrystalline structure is critical for the retention of temporary shape at ambient temperature and the recovery of original shape above Tm for the PEG phase in the copolymer film. Upon soaking the film in water for 5 days, it swelled by ≈660 vol % (590 wt %) with a density change from 1.15 to 1.02 g/cm3. Furthermore, we demonstrated that the film exhibits moisture-responsive behavior within just 10 s upon exposing only one of its surfaces to humid air.
HIV, HBV and HCV Coinfection Prevalence in Iran - A Systematic Review and Meta-Analysis (2016)

We found that PWID are severely and disproportionately affected by HIV and the other two infections, HCV and HBV. Screenings of such coinfections need to be reinforced to prevent new infections and also reduce further transmission in their community and to others.
Frontispiece: Single‐Scan 13C Diffusion‐Ordered NMR Spectroscopy of DNP‐Hyperpolarised Substrates (2017)

Dissolution dynamic nuclear polarisation (D-DNP) provides dramatic signal enhancements for solution-state NMR. The short-lived nature of the polarisation in solution, however, makes the acquisition of multidimensional data challenging. Here, using a spatial encoding strategy, spectrally diffusion-ordered NMR spectroscpy (DOSY) data are acquired in a single scan from DNP-hyperpolarised substrates. The resulting method has a great potential for the analysis of mixtures. For more information, see the Communication by J.-N. Dumez et al. on page 16722 ff.
Racial Differences in the Prevalence of Chronic Kidney Disease among Participants in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Cohort Study (2006)

The racial disparity in the incidence of ESRD exemplified by the three- to four-fold excess risk among black compared with white individuals in the United States is not reflected in the prevalence of less severe degrees of impaired kidney function among black compared with white individuals. The four-variable Modification of Diet in Renal Disease study equation was used to evaluate the black-to-white prevalence of impaired kidney function with increasing severity of impairment among participants in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study, a nationally representative, population-based cohort of individuals who are 45 yr and older. An estimated GFR (eGFR)<60 ml/min per 1.73 m2 was present in 43.3% of the 20,667 REGARDS participants and was slightly less prevalent among black than white patients (33.7 versus 49.9%; prevalence odds ratio 0.51; 95% confidence interval [CI] 0.48 to 0.54). The lower prevalence among black patients was not uniform as eGFR declined. After controlling for other patient characteristics, the black-to-white odds ratio was 0.42 (95% CI 0.40 to 0.46) at an eGFR of 50 to 59 ml/min per 1.73 m2 and increased to 1.73 (95% CI 1.02 to 2.94) at an eGFR of 10 to 19 ml/min per 1.73 m2. The disparity in prevalence of impaired kidney function among white compared with black patients reversed as the severity of impaired kidney function increased. Factors that are responsible for the increasing prevalence of severely impaired kidney function among black patients remain to be determined.
Functional characterization of MUC17 in pancreatic adenocarcinoma cells (2008)

1938 Mucin glycoproteins are implicated in various cancer types and are being actively studied due to their deregulated expression patterns, which can differentiate normal tissues from their malignant counterparts. Of particular interest is our recently characterized mucin 17 (MUC17), a membrane-anchored glycoprotein that is normally expressed in the gastrointestinal tract. We have reported that MUC17 is aberrantly expressed in pancreatic tumor cells and tumor cell lines with no expression detected in the normal pancreas or in benign pancreatitis tissues (Moniaux N., et al. 2006, 281, 23676-23685). Therefore, our working hypothesis is that MUC17 is implicated in the pathogenesis of pancreatic cancer. The MUC17 gene encodes a message of 14.4 Kb. Due to the large size of MUC17, a retroviral system was used to express a stable MUC17-specific RNAi that knocked down expression in the MUC17 expressing AsPC-1 pancreatic adenocarcinoma cell line. Both single colony clones and clonal populations of knock-down cells were assessed alongside parental AsPC-1 or AsPC-1 cells expressing a stable scrambled RNAi sequence. MUC17 knocked down cell lines displayed increased growth kinetics with reduced doubling time. Adhesion to cell culture surface was similar between knock-down and control populations; however, an increased motility was observed in the absence of MUC17 (motility and wound-healing assays). Knock-down and control population cell lines showed similar aggregation in hanging drop aggregation assays. No difference was observed in tests for clonogenic potential or in soft agar assays for tumorigenic potential. Xenotransplantation of the AsPC-1 cell line/model produces tumors with differentiation ranging from well to poorly differentiated adenocarcinomas. In the absence of MUC17, increased tumor weights were observed; however, no statistical difference between clonal populations of parental and knock-down (p=.1967) or scrambled and knock-down (p=.3772) cell lines was detected due to a large variance among tumor weights. In conclusion, our in vitro and in vivo results show that the absence of MUC17 in the AsPC-1 pancreatic model results in a pattern of increased tumorigenic potential. MUC17 expression in pancreatic cancer may therefore be an attempt to prevent tumorigenic growth or could be a surrogate consequence of altered signaling pathways in the cancerous state. The potential for MUC17 to mediate adhesion while conveying outside signals to the intracellular machinery is great. Microarray analysis and mechanistic study of scrambled versus knock-down populations will be performed. Additionally, a pancreas-specific mouse model, in which K-Ras is genetically inactivated and results in pancreatic cancer, is under development. The model will be used to assess the role of the MUC17 mouse homologue mMUC17 (work, in part, was supported by the NIH grants UO1 CA 111294 and T32 CA09476).
Characteristic μ-Calculus Formulas for Underspecified Transition Systems (2005)

Underspecification, which is essential for specification formalisms, is usually expressed by equivalences, simulations, or logic approaches. We introduce underspecified transition systems (UTSs) as general model general model for underspecification, where, e.g., transitions point to sets of states. We argue for the generality of the UTSs by showing that the class of all UTSs is strictly more expressive than the standard equivalences and simulation approaches, in the sense that more sets of transition systems can be expressed. Additionally, a characteristic formula in terms of the μ-calculus is presented for every finite state UTS. Furthermore, we show that UTSs can finitely describe sets of transition systems, whenever they can be described finitely by the other standard approaches except for trace-set extension or μ-calculus descriptions.