gebhart/patrepeval huggingface dataset:
Feedforward simple control technique for on-chip all-digital three-phase AC/DC power-MOSFET converter with least components (2009)

A novel simple control technique for on-chip all-digital three-phase alternating current to direct current (AC/DC) power-metal oxide semiconductor field-effect transistors (MOSFET) converter with least components, which is employed to obtain small current and DC output voltage ripples as well as excellent performance, and using a feedforward simple control method for DC output voltage regulation is proposed. The proposed all-digital feedforward controller has the features of low cost, simple control, fast response, independence of load parameters and the switching frequency, it has no need for compensation, and high stability characteristics; moreover, the proposed controller consists of three operation amplifiers and few digital logic gates that are directly applied to the three-phase converter. The power-MOSFETs are also known as power switches, whose control signals are derived from the proposed all-digital feedforward controller. Instead of thyristors or diodes, the application of power-MOSFETs can reduce the loss of AC/DC converter that is proper to the power supply system. The input stage of an AC/DC converter functions as a rectifier and the output stage is a low pass inductor capacitor (LC) filter. The input AC sources may originate from miniature three-phase AC generator or low-power three-phase DC/AC inverter. The maximum output loading current is 0.8 A and the maximum DC output ripple is less than 200 mV. The prototype of the proposed AC/DC converter has been fabricated with Taiwan Semiconductor Manufacturing Company (TSMC) 0.35 µm 2P4M complementary MOS (CMOS) processes. The total chip area is 2.333×1.960 mm2. The proposed AC/DC converter is suitable for the following three power systems with the low power, DC/DC converter, low-dropout linear regulator and switch capacitor. Finally, the theoretical analysis is verified to be correct by simulations and experiments.
Systems analysis of protein signatures predicting cetuximab responses in KRAS, NRAS, BRAF and PIK3CA wild‐type patient‐derived xenograft models of metastatic colorectal cancer (2020)

Antibodies targeting the human epidermal growth factor receptor (EGFR) are used for the treatment of RAS wild-type metastatic colorectal cancer. A significant proportion of patients remains unresponsive to this therapy. Here, we performed a reverse-phase protein array-based (phospho)protein analysis of 63 KRAS, NRAS, BRAF and PIK3CA wild-type metastatic CRC tumours. Responses of tumours to anti-EGFR therapy with cetuximab were recorded in patient-derived xenograft (PDX) models. Unsupervised hierarchical clustering of pretreatment tumour tissue identified three clusters, of which Cluster C3 was exclusively composed of responders. Clusters C1 and C2 exhibited mixed responses. None of the three protein clusters exhibited a significant correlation with transcriptome-based subtypes. Analysis of protein signatures across all PDXs identified 14 markers that discriminated cetuximab-sensitive and cetuximab-resistant tumours: PDK1 (S241), caspase-8, Shc (Y317), Stat3 (Y705), p27, GSK-3β (S9), HER3, PKC-α (S657), EGFR (Y1068), Akt (S473), S6 ribosomal protein (S240/244), HER3 (Y1289), NF-κB-p65 (S536) and Gab-1 (Y627). Least absolute shrinkage and selection operator and binominal logistic regression analysis delivered refined protein signatures for predicting response to cetuximab. (Phospo-)protein analysis of matched pretreated and posttreated models furthermore showed significant reduction of Gab-1 (Y627) and GSK-3β (S9) exclusively in responding models, suggesting novel targets for treatment.
Fabrication with high-performance materials and light-weight structures by direct metal deposition (2014)

The fabrication of dense metallic parts by direct metal deposition is state of the art in various industrial fields, e. g. aviation, energy, tooling, medical technology or automotive. Parts are generated by use of a fairly large variety of different alloys (e. g. Ni-, Co-, Ti-, Fe-base materials). Due to permanently increasing requirements (e. g. enhanced system efficiencies or environmental standards) in almost all fields of applications the use of very high-performance but also crack-sensitive materials is more and more required. This includes for example TiAl as well as Ni-Base superalloys. In addition the placement of metallic materials on composite structures (e. g. carbon fiber laminates) is a very challenging but interesting material combination due to the light weight of the resulting structure. In this paper, the processing with such interesting material combinations is discussed and examples of (potential) applications are shown.
Fatty acid and amino acid compositions of Brachychiton discolor, Brachychiton diversifolius, and Brachychiton acerifolius seeds (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFatty acid and amino acid compositions of Brachychiton discolor, Brachychiton diversifolius, and Brachychiton acerifolius seedsKoyyalamudi Sundar Rao, Gwyn P. Jones, Donald E. Rivett, and Daryl J. TuckerCite this: J. Agric. Food Chem. 1989, 37, 4, 916–917Publication Date (Print):July 1, 1989Publication History Published online1 May 2002Published inissue 1 July 1989https://pubs.acs.org/doi/10.1021/jf00088a019https://doi.org/10.1021/jf00088a019research-articleACS PublicationsRequest reuse permissionsArticle Views102Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
HDAC6 Expression Is Correlated with Better Survival in Breast Cancer (2004)

We conclude that the levels of HDAC6 mRNA expression may have potential both as a marker of endocrine responsiveness and also as a prognostic indicator in breast cancer. Additional investigations are warranted concerning the relationship between HDAC6 expression and response to endocrine therapy.
Strained Configurations in Three-Dimensional Analogues of Kekulé-Type Structures for Deltahedral Boranes (2002)

Localized structures analogous to the Kekulé structures for benzenoid hydrocarbons can be constructed for the deltahedral boranes B n H n 2- . These localized structures contain exactly three two-center two-electron (2c-2e) B-B bonds and n - 2 three-center two-electron (3c-2e) B-B-B bonds. The number of equivalent such Kekulé-type structures corresponds to the index of the symmetry group of the Kekulé structure, K , in the symmetry group, D , of the deltahedron. Three-dimensional Kekulé-type structures with the following configurations exhibit excessive strain and are therefore unfavorable: (i) structures having one or more pairs of boron atoms connected simultaneously by a 2c-2e B-B bond and a 3c-2e B-B-B bond (violation of the O'Neill-Wade restrictions); (ii) structures in which the three 2c-2e B-B bonds are excessively concentrated occupying only three or four vertices (the undesirable ∆, U, and Y configurations). Computations by Lipscomb and coworkers with partial retention of diatomic differential overlap (PRDDO) suggest that wide distribution of the three 2c-2e B-B bonds throughout the deltahedron and a minimum number of empty faces are more important than maximum symmetry in leading to the most favorable Kekulé-type structure.
Comparison of Radiohaloanalogues of Meta-Iodobenzylguanidine (MIBG) for a Combined Gene- and Targeted Radiotherapy Approach to Bladder Carcinoma (2005)

Targeted radiotherapy using radiolabelled meta-iodobenzylguanidine (MIBG) is a promising treatment option for bladder cancer, restricting the effects of radiotherapy to malignant cells thereby increasing efficacy and decreasing morbidity of radiotherapy. We investigated the efficacy of a combined gene therapy and targeted radiotherapy approach for bladder cancer using radiolabelled MIBG. The effectiveness of alternative radiohalogens and alternative preparations of radiolabelled MIBG for this therapeutic strategy were compared. Bladder cancer cells, EJ138, were transfected with a gene encoding the noradrenaline transporter (NAT) under the control of a tumour specific telomerase promoter, enabling them to actively take up radiolabelled MIBG. This resulted in tumour-specific cell kill. Uptake and retention of radioactivity in cells transfected with the NAT gene were compared with that obtained in cells transfected with the sodium iodide symporter (NIS) gene. Substantially greater uptake and longer retention of radioactivity in NAT-transfected cells was observed. Carrier-added (c.a.) [131I]MIBG, no-carrier added (n.c.a.) [131I]MIBG, and [211At]-labelled benzylguanidine (i.e. [211At] meta-astatobenzylguanidine (MABG)) were compared with respect to efficiency of induction of cell kill. N.c.a[(131)I]MIBG was more cytotoxic than c.a.[131I]MIBG. However, the alpha-emitter [211At]MABG was, by three orders of magnitude, more effective in causing tumour cell kill than the beta-emitter [131I]MIBG. We conclude that NAT gene transfer combined with the administration of n.c.a.[131I]MIBG or [211At]MABG, is a promising novel treatment approach for bladder cancer therapy.
Pressure and Strain Measurement on a 10° Control Surface of a Slender Cone in Hypersonic Flow (2022)

View Video Presentation: https://doi.org/10.2514/6.2022-4043.vid This paper presents the results of an experimental technique to acquire full-field pressure and strain fields on the windward side of a 10° flap attached to a slender cone-slice model. Tests were conducted in the Hypersonic Wind Tunnel (M = 5, Re= 9 – 14×〖10〗^6/m, air) at Sandia National Laboratories. The flap was coated with a fast-response, pressure-sensitive paint sprayed over a photoelastic coating and located near the trailing-edge of an axial slice along the 7° slender cone. This experiment was part of a sponsored project to develop the two-coating luminescent measurement technique and apply to high-speed, fluid-structure interaction environments. Results using a low-speed micropolarizer camera with four polarization orientations show that the technique is sensitive to pressure and strain, measuring an increasing pressure and decreasing strain from leading- to trailing-edge over the surface of the flap. At the low Re condition, the pressure signal captures the separated region near the flap leading edge and compares well with schlieren and oil-film measurements, the latter on a 10° wedge. Aerodynamic heating during the run does affect the pressure signal, likely resulting in an overestimation of pressure. Results using a conventional high-speed camera with a single linear polarizer captures the first bending and torsional modes of vibration when the flap is excited by transient shutdown conditions; however, coupling is difficult to detect in the pressure response due to baseline noise and the slower temporal response of the pressure coating.
A VoIP emergency services architecture and prototype (2006)

Providing emergency services in VoIP networks are vital to the success of VoIP. It not only presents design and implementation challenges, but also gives an opportunity to enhance the existing emergency call handling infrastructure. We propose an architecture to deliver emergency services in SIP-based VoIP networks, which can accommodate PSTN calls through PSTN to SIP gateways. Our architecture addresses the issues of identifying emergency calls, determining callers' locations, routing emergency calls to appropriate public safety answering points (PSAPs), and presenting required information to emergency call takers. We have developed a prototype implementation to prove our architecture's feasibility and scalability. We expect to undertake a pilot project at a working PSAP with our implementation once it is thoroughly tested.
Determination of a minimal deletion interval on chromosome band 8p21 in sporadic prostate cancer† (2001)

Loss of the short arm of chromosome 8 is a common event in prostatic neoplasms. Previous studies indicate that there may be up to three separate tumor suppressor genes on chromosome arm 8p, based on patterns of allelic loss. The responsible gene or genes have yet to be identified. In the present study, we used laser-capture microdissection of primary human prostate tumors and 17 microsatellite markers across chromosome band 8p21 to determine a minimal deletion interval. From an initial set of 120 cases, three tumors contained overlapping interstitial deletions on chromosome band 8p21. The three cases define an internally consistent minimal candidate tumor suppressor gene interval of approximately two megabases.
Finding Local Anomalies in Very High Dimensional Space (2010)

Time, cost and energy efficiency are critical factors for many data analysis techniques when the size and dimensionality of data is very large. We investigate the use of Local Outlier Factor (LOF) for data of this type, providing a motivating example from real world data. We propose Projection-Indexed Nearest-Neighbours (PINN), a novel technique that exploits extended nearest neighbour sets in the a reduced dimensional space to create an accurate approximation for k-nearest-neighbour distances, which is used as the core density measurement within LOF. The reduced dimensionality allows for efficient sub-quadratic indexing in the number of items in the data set, where previously only quadratic performance was possible. A detailed theoretical analysis of Random Projection(RP) and PINN shows that we are able to preserve the density of the intrinsic manifold of the data set after projection. Experimental results show that PINN outperforms the standard projection methods RP and PCA when measuring LOF for many high-dimensional real-world data sets of up to 300000 elements and 102600 dimensions.
Beam steering a quadrifilar helix antenna at S-band using a monopole (2016)

In this paper, an alternative approach to beam steering is presented through the use of a novel quadrifilar helix antenna, with a monopole in its center to get a low form factor and high performance. By altering the phase and amplitude of the monopole, the beam can be `steered' 360 degrees in the phi direction, and 90 degrees in the theta direction. Simulated test data showing antenna performance is compared to current beam steering methodologies. Measured results are compared to simulated test data.
Solution of the general moment problem via a one-parameter imbedding (2005)

This paper presents a computational theory for the general scalar moment problem. The formalism is sufficiently general to encompass problems in sensor arrays with arbitrary geometry and dynamics, and in nonuniform multidimensional sampling. Given a finite set of moments, the theory provides a test for the existence of a positive measure which is consistent with such data. At the same time, the theory also provides a characterization of all such consistent positive measures. It should be noted that classical results (e.g., in the theory of the trigonometric moment problem, Hamburger, Stieljes, Nevanlinna-Pick interpolation, etc.) are not applicable to the general setting sought herein where there is no natural shift operator in the space spanned by the integration kernels. The centerpiece of the theory is a differential equation which depends on the given finite set of moments and on an arbitrary positive function /spl Psi/-which plays the role of a "free parameter." The differential equation has an exponentially attractive point of equilibrium if and only if there exists a consistent positive measure. For each /spl Psi/, the fixed point determines a corresponding measure. Suitable choice of /spl Psi/ allows recovering any measure which is consistent with the data. The fixed point of the differential equation corresponds to an extremum of an entropy-like functional, and the differential equation is constructed via an appropriate homotopy that follows changes in the Lagrange multipliers from a convenient starting value to a value for the multipliers that corresponds to the given moments.
Supplementary Figure S6 from Highly Potent, Anthracycline-based Antibody–Drug Conjugates Generated by Enzymatic, Site-specific Conjugation (2023)

&lt;p&gt;In vivo evaluation of CD30-specific ADCs in mouse xenograft model.&lt;/p&gt;
Distributed Algorithms and Protocols (1988)

The use of distributed algorithms offers the prospect of great advances in computing speed. This book attempts to provide a clear, practical and up-to-date guide to distributed algoriths and protocols in the area of control. The first chapter lays the foundations; subsequent chapters, which can be studied independently of each other, consider different aspects of control. Each chapter consists of an analysis of the problem, followed by descriptions of the algorithms to solve it, with proofs of correctness. The book will be of use for undergraduate and graduate students in computer science, and also researchers and software engineers.
Optimization Techniques for Improving the Performance of Silicone‐Based Dielectric Elastomers (2017)

Dielectric elastomers are possible candidates for realizing products that are in high demand by society, such as soft robotics and prosthetics, tactile displays, and smart wearables. Diverse and advanced products based on dielectric elastomers are available; however, no elastomer has proven ideal for all types of products. Silicone elastomers, though, are the most promising type of elastomer when viewed from a reliability perspective, since in normal conditions they do not undergo any chemical degradation or mechanical ageing/relaxation. Within this review, different pathways for improving the electro‐mechanical performance of dielectric elastomers are highlighted. Various optimization methods for improved energy transduction are investigated and discussed, with special emphasis placed on the promise each method holds. The compositing and blending of elastomers are shown to be simple, versatile methods that can solve a number of optimization issues. More complicated methods, involving chemical modification of the silicone backbone as well as controlling the network structure for improved mechanical properties, are shown to solve yet more issues. From the analysis, it is obvious that there is not a single optimization technique that will lead to the universal optimization of dielectric elastomer films, though each method may lead to elastomers with certain features, and thus certain potentials.
Accurate determination of optical coefficients from chemical samples using terahertz time-domain spectroscopy and effective medium theory (2009)

A technique for calculating the optical constants of powdered materials that have been pressed into pellets along with a diluent such as polyethylene, as is commonly used in the spectroscopy community, is introduced. The simple Beer-Lambert law typically used to calculate the optical constants has the inherent weakness that it treats the absorbing medium as a single nonporous solid, as opposed to a dielectric material embedded within a medium. This leads to a systematic underestimation of both the absorption coefficient and the refractive index, especially at low filling factors. Effective medium theory provides a way to calculate more accurate optical constants and produces similar optical constants across a wide range of filling factors, including crucially at the low filling factors commonly used experimentally. The technique can also be extended to estimate the porosity of the samples and provide a true, preparation-independent value for the optical properties of the sample material.
Single Plane Illumination Fluorescence Correlation Spectroscopy (SPIM-FCS) probes inhomogeneous three-dimensional environments (2010)

The life sciences require new highly sensitive imaging tools, which allow the quantitative measurement of molecular parameters within a physiological three-dimensional (3D) environment. Therefore, we combined single plane illumination microscopy (SPIM) with camera based fluorescence correlation spectroscopy (FCS). SPIM-FCS provides contiguous particle number and diffusion coefficient images with a high spatial resolution in homo- and heterogeneous 3D specimens and live zebrafish embryos. Our SPIM-FCS recorded up to 4096 spectra within 56 seconds at a laser power of 60 microW without damaging the embryo. This new FCS modality provides more measurements per time and more, less photo-toxic measurements per sample than confocal based methods. In essence, SPIM-FCS offers new opportunities to observe biomolecular interactions quantitatively and functions in a highly multiplexed manner within a physiologically relevant 3D environment.
Supplemental Data from Development of a T-cell Receptor Mimic Antibody against Wild-Type p53 for Cancer Immunotherapy (2023)

&lt;p&gt;Suppl Table 1: Quantitation of T1-116C binding sites per target cell; Suppl Figure 1: Validation of the HLA-A2/p53RMP tetramer; Suppl Figure 2: ELISA screening of HLA-A2/p53RMP tetramer-reactive TCRm hybridoma supernatants; Suppl Figure 3: T1-116C staining of HL-60 cells; Suppl Figure 4: TP53 transcripts levels in cancer cell lines; Suppl Figure 5: The proteasome actively turns over p53 in NCI-H1395 lung cancer cells; Suppl Figure 6: The p53 TCRm T1-116C does not stain normal human peripheral blood mononuclear cells (PBMCs).&lt;/p&gt;
Multi-channel Acoustic Modeling using Mixed Bitrate OPUS Compression (2020)

Recent literature has shown that a learned front end with multi-channel audio input can outperform traditional beam-forming algorithms for automatic speech recognition (ASR). In this paper, we present our study on multi-channel acoustic modeling using OPUS compression with different bitrates for the different channels. We analyze the degradation in word error rate (WER) as a function of the audio encoding bitrate and show that the WER degrades by 12.6% relative with 16kpbs as compared to uncompressed audio. We show that its always preferable to have a multi-channel audio input over a single channel audio input given limited bandwidth. Our results show that for the best WER, when one of the two channels can be encoded with a bitrate higher than 32kbps, its optimal to encode the other channel with the highest bitrate possible. For bitrates lower than that, its preferable to distribute the bitrate equally between the two channels. We further show that by training the acoustic model on mixed bitrate input, up to 50% of the degradation can be recovered using a single model.