gebhart/patrepeval huggingface dataset:
Cerebrospinal fluid flow cytometry distinguishes psychosis spectrum disorders from differential diagnoses (2021)

Psychotic disorders are common and disabling mental conditions. The relative importance of immune-related mechanisms in psychotic disorders remains subject of debate. Here, we present a large-scale retrospective study of blood and cerebrospinal fluid (CSF) immune cell profiles of psychosis spectrum patients. We performed basic CSF analysis and multi-dimensional flow cytometry of CSF and blood cells from 59 patients with primary psychotic disorders (F20, F22, F23, and F25) in comparison to inflammatory (49 RRMS and 16 NMDARE patients) and non-inflammatory controls (52 IIH patients). We replicated the known expansion of monocytes in the blood of psychosis spectrum patients, that we identified to preferentially affect classical monocytes. In the CSF, we found a relative shift from lymphocytes to monocytes, increased protein levels, and evidence of blood-brain barrier disruption in psychosis. In fact, these CSF features confidently distinguished autoimmune encephalitis from psychosis despite similar (initial) clinical features. We then constructed machine learning models incorporating blood and CSF parameters and demonstrated their superior ability to differentiate psychosis from non-inflammatory controls compared to individual parameters. Multi-dimensional and multi-compartment immune cell signatures can thus support the diagnosis of psychosis spectrum disorders with the potential to accelerate diagnosis and initiation of therapy.
Interleukin-4 induction of the CC chemokine TARC (CCL17) in murine macrophages is mediated by multiple STAT6 sites in the TARC gene promoter (2006)

The induction of mTARC by IL-4 results from cooperative interactions between STAT6 sites within the mTARC gene promoter. Significantly, we have shown that transfer of the nine most proximal mTARC STAT6 sites in their endogenous conformation confers potent (up to 130-fold) IL-4 inducibility on heterologous promoters. These promoter elements constitute important and sensitive IL-4-responsive transcriptional units that could be used to drive transgene expression in sites of Th2 inflammation in vivo.
Effects of topical mechlorethamine on skin lesions of psoriasis (1970)

Topical applications of aqueous solutions of mechlorethamine hydrochloride were given to 12 patients with resistant psoriasis. Ten had definite improvement of their lesions, some with dramatic resolution. No systemic toxicity was detected in any patient but the development of hypersensitivity to this drug precluded its prolonged use.
Error limits for evidential breath alcohol analysis (2000)

The paper discusses the proposals by BODE with regard to the safety margin that should be applied to the results of evidential breath analyzers. It becomes apparent that his proposal of adding different types of errors to the legal limits of breath alcohol concentration is scientifically not correct. Psycho-physical breath alcohol base levels are based on a mean blood/breath distribution ratio of 2100:1 and a recently calculated quotient of 2260:1. A comparison of the respective limit values shows that the safety supplements add up to three times the permitted calibration error as well as twice the permitted road traffic error. Reaching a legal limit in breath alcohol concentration is closely linked to the probability of exceeding the base level, which is at least as high as with blood alcohol analysis. Therefore the results of evidential breath analyzers are valid without any type of correction.
RND multidrug efflux pumps: what are they good for? (2013)

Multidrug efflux pumps are chromosomally encoded genetic elements capable of mediating resistance to toxic compounds in several life forms. In bacteria, these elements are involved in intrinsic and acquired resistance to antibiotics. Unlike other well-known horizontally acquired antibiotic resistance determinants, genes encoding for multidrug efflux pumps belong to the core of bacterial genomes and thus have evolved over millions of years. The selective pressure stemming from the use of antibiotics to treat bacterial infections is relatively recent in evolutionary terms. Therefore, it is unlikely that these elements have evolved in response to antibiotics. In the last years, several studies have identified numerous functions for efflux pumps that go beyond antibiotic extrusion. In this review we present some examples of these functions that range from bacterial interactions with plant or animal hosts, to the detoxification of metabolic intermediates or the maintenance of cellular homeostasis.
Implementations of temperature detect and control for constant temperature supplier (2011)

More and more industry and daily life need higher accuracy constant temperature fluid supply.It's difficult to control the long-distance transmittal fluid temperature.The article researches how to detect liquid temperature and control it's temperature for constant temperature supplier.For more reliability,liquid temperature detect is a system,and liquid temperature control for supplier is another system;for higher efficiency,fuzzy logic control and better power level have been used,it can decrease waiting because of wrong liquid temperature.Especially,this method can used for long-distance transmittal supply.
Evaluation of thermally activated defects behaviors in nitrogen-doped Czochralski silicon single crystals using deep level transient spectroscopy (2023)

Abstract Thermally activated defect behaviors in nitrogen (N)-doped Czochralski silicon (Cz-Si) single crystals were investigated using deep level transient spectroscopy and quasi-steady-state photoconductance to confirm the crystals’ applicability in insulated gate bipolar transistors (IGBTs). The thermally activated defects, which were probably N-vacancy complexes and degraded the minority carrier lifetime, were detected with extremely low densities in N-doped Cz-Si compared with N-rich floating zone Si single crystals after heat treatments at 500 °C, resulting in a high remaining value of minority carrier lifetime. The difference was assumed to come from whether vacancies were released in the Si matrix during heat treatment. For the Cz-Si, vacancies were assumed to be strongly bound with oxygen atoms with concentrations of 10 17 atoms cm −3 . Therefore, vacancies were not released during heat treatment, resulting in low remaining N-vacancy complex densities. N-doped Cz-Si are potential materials for IGBTs because of their low densities from thermally activated defects.
Green Catalysis.Handbook of Green Catalysis, Band 1–3. Herausgegeben von Robert H. Crabtree. (2009)

Wiley-VCH, Weinheim 2009. 1082 S., geb., 499.00 €.—ISBN 978-3527315772
The peroxisome proliferator activated receptor regulates malic enzyme gene expression. (1994)

A new regulatory element for peroxisome proliferator activated receptor (PPAR)/retinoid X receptor (RXR) heterodimers was found in the promoter of the malic enzyme gene. Similar to previously characterized peroxisome proliferator response elements (PPREs), it consists of a direct repeat of sequences related to the half-site consensus AGGTCA with an interspacing of 1 base pair. Specific binding of PPAR/RXR heterodimers to this element was demonstrated. Furthermore, this sequence conferred ciprofibrate responsiveness of a reporter through the homologous malic enzyme or heterologous thymidine kinase promoters. This PPRE presumably mediates the transcriptional effects of peroxisome proliferators on malic enzyme expression. The presence of a PPRE in the promoter of this lipogenic enzyme suggests a broader function for the PPAR in the regulation of lipid metabolism.
A Perspective on WAMS Analysis Tools for Tracking of Oscillatory Dynamics (2007)

Over roughly the past two decades, an architecture has evolved for using wide area measurement systems to monitor power-system oscillatory dynamics. This includes, but is not limited to, the use of phasor measurement units and advanced signal processing algorithms. Today, this architecture is further evolving toward real-time operation applications. This paper provides a perspective upon these analysis approaches, and defines and clarifies analysis operations, interactions, and application conditions. An overview of WAMS analysis approaches is given along with several examples from the western North American power system.
Congestion control strategies for mixed X.25/frame relay networks (2002)

The paper addresses traffic management strategies in multi-service corporate communication networks. In particular, it proposes a unified congestion control scheme for mixed X.25/frame relay networks which meets users' requirements of effectiveness, fairness, and implementation efficiency. Key elements of the design include early detection of impending congestion by the various network resources, explicit notification of congestion information to the affected network services, and the use of adaptive rate and window control mechanisms by the various services to limit traffic admission into the network during overload. A comprehensive simulation test-bed was constructed for evaluating and tuning the proposed algorithms, and the results were verified against live networking equipment. Simulation results confirm the success of the congestion control strategy in maximizing network throughput, and minimizing users' packet loss rate and end-to-end delay under a wide range of congestion situations. The described algorithms have been successfully incorporated in the design of large multi-service data communication networks.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Radiocarbon Chronology of Holocene Hydrologic Changes in Northeastern Mali (1983)

A detailed chronology of hydrological changes that occurred in northeastern Mali during the Holocene is based on approximately 30 14 C dates of molluscs which were collected from the lacustrine and paludal deposits of the Ine Sakane sand sea. The presence of cemented paleodunes indicates that the end of the Pleistocene was and arid period. This was followed by an early Holocene lacustrine episode (ca. 9500–6500 yr B.P.) during which numerous lakes occupied depressions formed in the Cretaceous limestones and between the sand ridges. These lakes reflect a significant rise in the water table. Between ca. 6500 and 5500 yr B.P. the lakes dried up, although the water table remained close to the ground surface in several areas. Calcareous concretions formed at the water table fringe during this time, thereby “fossilizing” some of the middle Holocene dunes. A second lacustrine episode is dated between ca. 5500 and 4500 yr B.P.; it corresponds to the establishment of numerous Neolithic settlements in the area. Arid conditions have developed since about 4500 yr B.P. to attain the conditions of the present day. The isotopic composition ( 18 O and 13 C) of the fauna reflects highly variable hydrological conditions. Groundwaters were recharged by precipitation which was occasionally very depleted in heavy oxygen (δ 18 O ≅ −13%.). Evaporation induced an enrichment in 18 O; high concentrations characterize some lakes. The 13 C content of fossil shells reflect: (1) species ecological requirements, (2) isotopic composition of the total inorganic dissolved carbon (TIDC) in groundwaters, and (3) the lake metabolism.
ChemInform Abstract: DERIVATIVES OF S‐TRIAZOLO(5,1‐A)ISOINDOLE (1981)

Abstract Die Methylengruppe im Triazoloisoindol (I) ist sehr reaktionsfahig, so daß (I) zur Synthese der verschiedensten Cyaninfarb‐ , stoffe geeignet ist.
Figure S1 from Epithelial-to-Mesenchymal Transition Rewires the Molecular Path to PI3K-Dependent Proliferation (2023)

&lt;p&gt;PDF 921K, Akt inhibition reduces serum-independent proliferation&lt;/p&gt;
Nuclear Magnetic Resonance Reveals Molecular Species in Carbon Nanodot Samples Disclosing Flaws (2022)

Abstract Carbon nanodots are currently one of the hot topics in the nanomaterials world, due to their accessible synthesis and promising features. However, the purification of these materials is still a critical aspect, especially for syntheses involving molecular precursors. Indeed, the presence of unreacted species or small organic molecules formed during solvothermal treatments can affect the properties of the synthesized nanomaterials. To illustrate the extreme importance of this issue, we present two case studies in which insufficient purification results in misleading conclusions regarding the chiral and fluorescent properties of the investigated materials. Key to identify molecular species is the use of nuclear magnetic resonance, which proves to be an effective tool. Our work highlights the need to include nuclear magnetic resonance as a standard characterization technique for carbon‐based nanomaterials, to minimize the risk of observing properties that arise from molecular species, rather than the target carbon nanodots.
People With Recurrent Low Back Pain Respond Differently to Trunk Loading Despite Remission From Symptoms (2010)

Despite symptom remission, DM EMG during predictable loading and DM and SM EMG during unpredictable loading were less in people with recurrent LBP than healthy participants.
Early Prediction of COVID-19 Patient Survival by Targeted Plasma Multi-Omics and Machine Learning (2022)

The recent surge of coronavirus disease 2019 (COVID-19) hospitalizations severely challenges healthcare systems around the globe and has increased the demand for reliable tests predictive of disease severity and mortality. Using multiplexed targeted mass spectrometry assays on a robust triple quadrupole MS setup which is available in many clinical laboratories, we determined the precise concentrations of hundreds of proteins and metabolites in plasma from hospitalized COVID-19 patients. We observed a clear distinction between COVID-19 patients and controls and, strikingly, a significant difference between survivors and nonsurvivors. With increasing length of hospitalization, the survivors' samples showed a trend toward normal concentrations, indicating a potential sensitive readout of treatment success. Building a machine learning multi-omic model that considers the concentrations of 10 proteins and five metabolites, we could predict patient survival with 92% accuracy (area under the receiver operating characteristic curve: 0.97) on the day of hospitalization. Hence, our standardized assays represent a unique opportunity for the early stratification of hospitalized COVID-19 patients.
HiC-spector: a matrix library for spectral and reproducibility analysis of Hi-C contact maps (2017)

Supplementary data are available at Bioinformatics online.
Effetto dinamico della posizione di montaggio del volano (2007)

In un sistema motore-utilizzatore, la variazione periodica della coppia motrice od operatrice, ovvero quella dei momenti di inerzia d'inerzia, può provocare un grado di irregolarità del moto tale da compromettere lo svolgimento delle funzioni richieste. La riduzione della irregolarità di moto può essere ottenuta con soluzioni di varia natura e complessità: l’inserimento di un volano rappresenta il metodo più semplice ed economico. Se, da un lato, allo scopo di minimizzare gli ingombri, appare opportuno montare il volano sull’albero più veloce, da un altro punto di vista occorre considerare che l’elasticità degli alberi e la presenza di giochi possono influenzare in modo determinante la risposta del sistema, fino ad aumentare, anziché ridurre, il grado di irregolarità. Anche l’entità della sollecitazione di torsione della trasmissione è determinata dal posizionamento del volano. &#13;\nIn questo lavoro viene impiegato un modello elastodinamico a parametri concentrati per valutare la configurazione del sistema che massimizza l’efficacia del volano in differenti condizioni di lavoro e per diverse cause di disturbo periodico.
Reaction of Naphtho‐ and Benzimidazolequinones with Enamines. Synthesis of Condensed Benzofurans and Indoles. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
A Patient with a History of Chronic Lymphocytic Leukemia Presents with Rash and Elevated Liver Biochemistries (2018)

We present a 71-year-old female with a history of chronic lymphocytic leukemia on venetoclax, Roux-en-Y gastric bypass, prior venous thromboembolism and shingles who presented to a local hospital with several days of severe, sharp, localized epigastric pain associated with nausea and vomiting. On presentation at her local hospital she denied fevers, chills, weight loss, or other constitutional symptoms. She also denied recent travel, sick contacts, or medication changes. She was afebrile with normal vital signs. Her physical exam was normal, and specifically her abdomen was nondistended, nontender, and without hepatosplenomegaly. Laboratory assessment demonstrated lymphocytic leukocytosis to 23.9 x 109 cells/L, and elevated liver biochemistries with AST 97 U/L, ALT 91 U/L, and alkaline phosphatase 91 /L as well as lipase 87 U/L with normal bilirubin. Abdominal ultrasound revealed a normal gallbladder and common bile duct with neither cholelithiasis nor choledocholithiasis. CT abdomen was similarly unremarkable, revealing, however, prominent but stably enlarged periportal lymph nodes relative to a previous study. Following local hospital admission, the patient's symptoms and laboratory abnormalities progressed (AST 598 U/L, ALT 526 U/L, ALK 169, lipase 504 U/L though bilirubin remained normal), suggesting worsening hepatitis and evidence of pancreatitis. She was transferred to our facility for consideration of endoscopic retrograde cholangiopancreatography. On presentation, her vitals and laboratory findings were similar to previous, except physical exam was now notable for a diffusely erythematous rash with scattered unroofed vesicles across her neck, thorax, and abdomen and evaluation of her oropharynx revealed raised white lesions on the hard palate (Fig 1). These lesions were neither pruritic nor painful.2212 Figure 1 No Caption available.Given the rash and immunosuppression from CLL on venetoclax, we were concerned for viral infection, and therefore she was empirically started on intravenous acyclovir. Oral and skin lesion swabs confirmed the presence of varicella-zoster virus (VZV) by polymerase chain reaction. She was diagnosed with disseminated VZV with visceral involvement resulting in hepatitis and pancreatitis. The patient improved clinically with liver biochemistries peaking after 4 days of therapy. She completed 14 days of intravenous therapy and was transitioned to oral acyclovir for life-long suppression. After 3 months, venetoclax was restarted without recurrence.
ABCD (2000)

To guarantee typesafe execution, Java and other strongly typed languages require bounds checking of array accesses. Because array-bounds checks may raise exceptions, they block code motion of instructions with side effects, thus preventing many useful code optimizations, such as partial redundancy elimination or instruction scheduling of memory operations. Furthermore, because it is not expressible at bytecode level, the elimination of bounds checks can only be performed at run time , after the bytecode program is loaded. Using existing powerful bounds-check optimizers at run time is not feasible, however, because they are too heavyweight for the dynamic compilation setting. ABCD is a light-weight algorithm for elimination of Array Bounds Checks on Demand. Its design emphasizes simplicity and efficiency. In essence, ABCD works by adding a few edges to the SSA value graph and performing a simple traversal of the graph. Despite its simplicity, ABCD is surprisingly powerful. On our benchmarks, ABCD removes on average 45% of dynamic bound check instructions, sometimes achieving near-ideal optimization. The efficiency of ABCD stems from two factors. First, ABCD works on a sparse representation. As a result, it requires on average fewer than 10 simple analysis steps per bounds check. Second, ABCD is demand-driven . It can be applied to a set of frequently executed (hot) bounds checks, which makes it suitable for the dynamic-compilation setting, in which compile-time cost is constrained but hot statements are known.
Event-by-event PET image reconstruction using list-mode origin ensembles algorithm (2016)

There is a great demand for real time or event-by-event (EBE) image reconstruction in emission tomography. Ideally, as soon as event has been detected by the acquisition electronics, it needs to be used in the image reconstruction software. This would greatly speed up the image reconstruction since most of the data will be processed and reconstructed while the patient is still undergoing the scan. Unfortunately, the current industry standard is that the reconstruction of the image would not start until all the data for the current image frame would be acquired. Implementing an EBE reconstruction for MLEM family of algorithms is possible, but not straightforward as multiple (computationally expensive) updates to the image estimate are required. In this work an alternative Origin Ensembles (OE) image reconstruction algorithm for PET imaging is converted to EBE mode and is investigated whether it is viable alternative for real-time image reconstruction. In OE algorithm all acquired events are seen as points that are located somewhere along the corresponding line-of-responses (LORs), together forming a point cloud. Iteratively, with a multitude of quasi-random shifts following the likelihood function the point cloud converges to a reflection of an actual radiotracer distribution with the degree of accuracy that is similar to MLEM. New data can be naturally added into the point cloud. Preliminary results with simulated data show little difference between regular reconstruction and EBE mode, proving the feasibility of the proposed approach.
ChemInform Abstract: DENSIMETRIC INVESTIGATIONS ON PRASEODYMIUM AQUA AND NITRATO COMPLEX FORMATION IN AQUEOUS SOLUTIONS OF ELECTROLYTES (1977)

Abstract Im System Pr(NO 3 ) 3 ‐NaNO 3 ‐H 2 O (cpr(uoi)a : 0,02‐0,05 mol 1", 0mm,′ :O,l‐8 mol 1 ′) und in Pr(NO3)3‐Lösung im Konzentrationsbereich 0,02‐5,23 mol 1" wird mit Hilfe der Methode der scheinbaren Molvolumina die Bildung von Nitratokomplexen untersucht.
Effect of progesterone on basal LH and episodic LH and FSH secretion in heifers (1982)

Heifers between Days 6 and 10 of the cycle were allocated at random to groups of 8 and treated with (i) a 4% progesterone-releasing intravaginal device (PRID) + oestrogen capsule for 12 days; (ii) 4% PRID for 12 days; (iii) 20% PRID for 12 days; (iv) 4% for 14 days; or (v) 20% PRID for 14 days. Blood was obtained daily during treatment and at 2- or 4-h intervals for 72 h after removal of PRIDs. Some animals were sampled every 20 min for 4.676 h on the 3rd day after PRID insertion, and 1 day before and 36 h after removal of the PRID insertion, and 1 day before and 36 h after removal of the PRID. During progesterone treatment there was: (i) no correlation between concentrations of progesterone and LH within days; (ii) a significant negative correlation between progesterone and days (P less than 0.01) and also between progesterone and LH over days (P less than 0.01); (iii) the overall correlation co-efficient between LH and days was positive (P less than 0.05). The amplitude of LH or FSH episodes was not affected as progesterone concentrations declined during PRID treatment, but the number of LH (but not FSH) episodes was increased (p less than 0.01). After PRID removal, the amplitude of both LH and FSH episodes increased (P less than 0.01). We suggest that progesterone is part of a negative feedback complex on LH secretion in cattle and that this effect is apparently mediated through frequency of episodic LH release.