gebhart/patrepeval huggingface dataset:
VARIABLE‐INTERVAL SCHEDULE PERFORMANCE IN OPEN AND CLOSED ECONOMIES (1990)

In two experiments, pigeons obtained food according to variable-interval schedules. In the first experiment, equivalent variable-interval schedules with average interreinforcer intervals ranging between 10 and 80 s in different conditions were studied in both open and closed economies. Response rates increased as reinforcement frequency decreased in the closed economy. By contrast, in the open economy response rates decreased for 1 bird and were variable for the other as reinforcement frequency decreased. The second experiment showed that the differences in the functions between responding and reinforcement frequency in the two types of economies were not due to changes in deprivation level. These results suggest that open and closed economies yield different behavioral effects. This conclusion is supported further by a reconsideration of previous findings that appear counter to the conclusion.
The BRAIN project:looking for B-mode from Dome-C (2006)

Texte integral disponible sur http://proc.sf2a.asso.fr/sf2a06.php
CaO: I, Fabrication and Characterization* (1969)

Two processes for hot‐pressing CaO to less than 1% porosity are described and discussed. One process is without additives at about 1200°C, and the other is with additives of NaF or LiF (preferably EiF) at about 1000°C. The dense bodies are characterized in terms of grain size, surface annealing, and the type and content of impurities and residual additives. Iron and silicon are prevalent impurities and undergo changes on subsequent firing, especially above 1650°C. Gaseous impurities, H 2 O and CO 2 , which are released from powders during hot‐pressing, may cause explosions if proper caution is not used. They are also trapped in varying small quantities in dense bodies as hydroxide and carbonate compounds and are surprisingly tenacious. Lithium is readily eliminated from bodies made with LiF. Fluorine, though more tenacious, can also be reduced with firing, but not as readily as in MgO. Some observations on possible densification mechanisms are presented, including possible effects of impurities.
Quantifying Protein-Specific N-Glycome Profiles by Focused Protein and Immunoprecipitation Glycomics (2019)

Serum N-glycans have been reported to be potential diagnostic and therapeutic biomarkers for many diseases and conditions, such as inflammation, fibrosis, and cancer progression. We previously described the focused protein glycomic analysis (FPG) from gel-separated serum proteins. With this methodology, we sought novel glycan biomarkers for nonalcoholic steatohepatitis (NASH) and successfully identified some N-glycans that were significantly elevated in NASH patients compared to nonalcoholic fatty liver patients. Among them, trisialylated monofucosylated triantennary glycan (A3F) of alpha-1 antitrypsin showed the most dynamic change. For rapid identification of N-glycans on the focused proteins, we constructed a simplified method called immunoprecipitation glycomics (IPG), where the target proteins were immunoprecipitated with affinity beads and subsequently subjected to glycomic analysis by MALDI-TOF MS. Focusing on alpha-1 antitrypsin and ceruloplasmin as the target proteins, we compared the values of N-glycans determined by FPG and IPG. The quantified values of each N-glycan by these two methods showed a statistically significant correlation, indicating that high throughput and quantitative N-glycomics of targeted proteins can be achieved by the simplified IPG method. Thus, an analytical strategy combining FPG and IPG can be adapted to general biomarker discovery and validation in appropriate disease areas.
Early warning system of impending rock failure for safety in mines and excavations. Open file report (final) (1973)

This research was undertaken to develop a system capable of detecting changes in the structure of rocks, leading to failure of mine roofs, and/or excavations. A prototype system was developed, field tested, and delivered to the Bureau of Mines for further evaluation and research. This system is based on the analysis of acoustic signals generated on the surface of the roof by an impact device and which are reflected or backscattered by flaws and discontinuities in the rock. The specially designed impact source is capable of generating high frequency acoustic signals with excellent repeatability. The system can also be used in conjunction with conventional acoustic pulse transducers. The received signal is digitized and the data transferred to a minicomputer for processing and display. This capability allows the immediate determination of wave velocity and/or distance to a reflecting interface. (GRA)
CD4+ T-Cell-Independent Secondary Immune Responses to Pneumocystis Pneumonia (2016)

Pneumocystis pneumonia is a major cause of morbidity and mortality among immunocompromised patients, especially in the context of HIV/AIDS. In the murine model of Pneumocystis pneumonia, CD4(+) T-cells are required for clearance of a primary infection of Pneumocystis, but not the memory recall response. We hypothesized that the memory recall response in the absence of CD4(+) T-cells is mediated by a robust memory humoral response, CD8(+) T-cells, and IgG-mediated phagocytosis by alveolar macrophages. To investigate the role of CD8(+) T-cells and alveolar macrophages in the immune memory response to Pneumocystis, mice previously challenged with Pneumocystis were depleted of CD8(+) T-cells or alveolar macrophages prior to re-infection. Mice depleted of CD4(+) T-cells prior to secondary challenge cleared Pneumocystis infection within 48 h identical to immunocompetent mice during a secondary memory recall response. However, loss of CD8(+) T-cells or macrophages prior to the memory recall response significantly impaired Pneumocystis clearance. Specifically, mice depleted of CD8(+) T-cells or alveolar macrophages had significantly higher fungal burden in the lungs. Furthermore, loss of alveolar macrophages significantly skewed the lung CD8(+) T-cell response toward a terminally differentiated effector memory population and increased the percentage of IFN-γ(+) CD8(+) T-cells. Finally, Pneumocystis-infected animals produced significantly more bone marrow plasma cells and Pneumocystis-specific IgG significantly increased macrophage-mediated killing of Pneumocystis in vitro. These data suggest that secondary immune memory responses to Pneumocystis are mediated, in part, by CD8(+) T-cells, alveolar macrophages, and the production of Pneumocystis-specific IgG.
Introduction of a Flexible Polymeric Heart Valve Prosthesis With Special Design for Mitral Position (2003)

Polycarbonaturethane valve prostheses with special design for mitral position show excellent hemodynamic performance and durability in vivo. Calcification and structural changes are mild compared with bioprostheses. Controlled clinical studies are planned.
Is Plasma Cortisol Binding Globulin (CBG) Influenced by Synacthen Administration? (1999)

Conference Abstract| July 01 1999 Is Plasma Cortisol Binding Globulin (CBG) Influenced by Synacthen Administration? RA Rees; RA Rees 1Division of Neuroscience & Psychological Medicine, Imperial College School of Medicine, Charing Cross Hospital, London W6 8RF Search for other works by this author on: This Site PubMed Google Scholar J-Zadeh Alaghband; J-Zadeh Alaghband *Division of Investigative Science, Imperial College School of Medicine, Charing Cross Hospital, London W6 8RF Search for other works by this author on: This Site PubMed Google Scholar JF Laycock; JF Laycock 1Division of Neuroscience & Psychological Medicine, Imperial College School of Medicine, Charing Cross Hospital, London W6 8RF Search for other works by this author on: This Site PubMed Google Scholar J Jones; J Jones *Division of Investigative Science, Imperial College School of Medicine, Charing Cross Hospital, London W6 8RF Search for other works by this author on: This Site PubMed Google Scholar G Carter; G Carter *Division of Investigative Science, Imperial College School of Medicine, Charing Cross Hospital, London W6 8RF Search for other works by this author on: This Site PubMed Google Scholar WM Kohler; WM Kohler *Division of Investigative Science, Imperial College School of Medicine, Charing Cross Hospital, London W6 8RF Search for other works by this author on: This Site PubMed Google Scholar W Dhillo; W Dhillo *Division of Investigative Science, Imperial College School of Medicine, Charing Cross Hospital, London W6 8RF Search for other works by this author on: This Site PubMed Google Scholar D O'shea D O'shea *Division of Investigative Science, Imperial College School of Medicine, Charing Cross Hospital, London W6 8RF Search for other works by this author on: This Site PubMed Google Scholar Clin Sci (Lond) (1999) 97 (s41): 5P. https://doi.org/10.1042/cs097005Pb Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation RA Rees, J-Zadeh Alaghband, JF Laycock, J Jones, G Carter, WM Kohler, W Dhillo, D O'shea; Is Plasma Cortisol Binding Globulin (CBG) Influenced by Synacthen Administration?. Clin Sci (Lond) 1 July 1999; 97 (s41): 5P. doi: https://doi.org/10.1042/cs097005Pb Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentAll JournalsClinical Science Search Advanced Search This content is only available as a PDF. © 1999 The Biochemical Society and the Medical Research Society1999 Article PDF first page preview Close Modal You do not currently have access to this content.
On the design of signals for sequential and nonsequential detection systems with feedback (1966)

The design of signals for binary communication systems employing feedback has previously been considered by Turin. A delayless, infinite-bandwidth forward channel disturbed by additive, white, Gaussian noise is assumed. At each instant of time, the log likelihood ratio of the two possible signals is fed back to the transmitter via a noiseless and delayless feedback channel. The forward-channel signals are said to be optimally designed when the feedback information is so utilized that the average (for sequential detection) or fixed (for nonsequential detection) transmission time is minimized, subject to a specified probability of error. Average and peak power constraints are also placed on the signals. Turin has solved the signal design problem for extreme values (i.e., very large or equal to one) of the peak-to-average power constraint ratio. These results are extended in this paper to arbitrary values of the power constraint ratio, for both sequential and nonsequential detection.
Hydrogen Storage Properties of Metal Nitroprussides M[Fe(CN)5NO], (M = Co, Ni) (2006)

The volumetric hydrogen adsorption isotherms of two isostructural dehydrated cubic metal nitroprussides M[Fe(CN)5NO] (M = Co2+, Ni2+) have been measured up to a pressure of 760 Torr at 77 and 87 K. These materials are among the most efficient H2 sorbents based on porous coordination polymers reported to date. The H2 uptake in both materials is approximately 1.6 wt % at 77 K and 760 torr. These H2 capacities match those reported recently in the structurally related M3[Co(CN)6]2 compounds and are approximately 25% higher than those reported for Zn4O(1,4-benzenedicarboxylate)3 under the same conditions of temperature and pressure. The isosteric heats of H2 adsorption calculated from the 77 and 87 K isotherms for both materials were found to vary from approximately 7.5 kJ/mol at 0.40 wt % coverage to approximately 5.5 kJ/mol at 1.2 wt % coverage. The N2 BET surface areas were determined to be 634 m2/g and 523 m2/g for M = Ni and M = Co, respectively.
Monoclonal antibodies potentially useful for diagnosis of squamous cell oral carcinoma (1988)

Abstract Five murine monoclonal antibodies (MoAbs) (F1/A, F1/B, F1/C, F1/D, and F1/E) were produced that react with different antigenic determinants on the cell surface of human oral squamous cell carcinomas. They each immunoprecipitate a complex containing three polypeptides with molecular weights 38, 80, and 180 kD on SDS polyacrylamide gel electrophoresis under reducing conditions. These monoclonal antibodies were used in immunohistochemical analysis to study frozen tissue sections of surgical specimens from the floor of the mouth. Antibodies F1/A and F1/B: 1) detected virtually all malignant cells in 13/14 cases of high‐grade squamous cell oral carcinomas; 2) reacted weakly with nonneoplastic cells in oral biopsies showing severe dysplasia; and 3) did not react with normal stratified squamous epithelium. In comparison, antibodies F1/C, F1/D, and F1/E reacted only with approximately 50% of oral carcinomas, but not with cells in dysplastic oral lesions. These MoAbs were able to sensitize squamous tumor cells to killing by antibody‐dependent cellular cytotoxicity (ADCC) cells and complement‐mediated cytolysis. Our data suggest that these antibodies may be potentially useful for diagnosis and perhaps treatment of squamous cell oral carcinoma.
Dimesityldioxiran — ein in Substanz stabiles Dioxiran (1994)

In 10 mg pro Ansatz ist das Dioxiran 2 präparativ aus dem Diazomethan 1 zugänglich. Bei 2 handelt es sich um das erste auch in Substanz bei Raumtemperatur stabile Dioxiran. Ein Intermediat seiner Synthese, höchstwahrscheinlich das Carbonyloxid, ließ sich bei − 78 °C in Lösung ebenfalls einige Stunden halten. magnified image
A methyltransferase required for proper timing of the vernalization response in Arabidopsis (2015)

Prolonged exposure to winter cold enables flowering in many plant species through a process called vernalization. In Arabidopsis, vernalization results from the epigenetic silencing of the floral repressor flowering locus C (FLC) via a Polycomb Repressive Complex 2 (PRC2)-mediated increase in the density of the epigenetic silencing mark H3K27me3 at FLC chromatin. During cold exposure, a gene encoding a unique, cold-specific PRC2 component, vernalization insensitive 3 (VIN3), which is necessary for PRC2-mediated silencing of FLC, is induced. Here we show that set domain group 7 (SDG7) is required for proper timing of VIN3 induction and of the vernalization process. Loss of SDG7 results in a vernalization-hypersensitive phenotype, as well as more rapid cold-mediated up-regulation of VIN3. In the absence of cold, loss of SDG7 results in elevated levels of long noncoding RNAs, which are thought to participate in epigenetic repression of FLC. Furthermore, loss of SDG7 results in increased H3K27me3 deposition on FLC chromatin in the absence of cold exposure and enhanced H3K27me3 spreading during cold treatment. Thus, SDG7 is a negative regulator of vernalization, and loss of SDG7 creates a partially vernalized state without cold exposure.
ATNT-15MIBEFRADIL DIHYDROCHORIDE WITH HYPOFRACTIONATED RADIATION FOR RECURRENT GLIOBLASTOMA: PRELIMINARY RESULTS OF A PHASE I DOSE EXPANSION TRIAL (2015)

BACKGROUND: Recurrent Glioblastoma Multiforme (GBM) has limited treatment options and the prognosis is poor. Our group recently performed a high-throughput drug screen for novel DNA repair inhibitors which identified mibefradil dihydrochloride, a T-type calcium channel blocker. Follow-up studies by our group and others subsequently revealed that mibefradil is active as a glioma radiosensitizer. Based on these findings, we sought to determine the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) of mibefradil and hypofractionated radiation (RT), in a Phase I study of patients with recurrent GBM. A subset of patients are enrolled on a molecular biomarker sub-study, in which the drug is administered prior to surgical re-resection, and the tissue is analyzed for tumor penetration and in situ activity. METHODS: The inclusion criteria are histologically proven GBM progressive or recurrent following RT and temozolomide treatment. Patients receive mibefradil, in escalating dose from 150mg/day until the maximum tolerated dose (MTD) or a dose of 350 mg/day is reached using a standard 3 + 3 design. RT consists of 5 fractions of 600 cGy each, delivered over 2 weeks for a total of 3,000 cGy using stereotactic, intensity-modulated RT. RESULTS: To date, eight patients have been enrolled including two patients on the molecular biomarker sub-study, and seven have been successfully treated. The first dose level cohort has completed accrual. Median progression-free survival was 2.5 months. One patient experienced a complete radiographic response on MRI and one had grade 3 or higher drug-related toxicity. CONCLUSIONS: This Phase I dose-escalation study assesses the safety and determines the MTD of mibefradil dihydrochloride as a novel radiosensitizer in patients with recurrent GBM. Our preliminary data suggest that mibefradil and RT can be safely co-administered with the potential to improve disease response as a novel radiosensitizer.
A simple proof of a theorem of Albert (1974)

A simple proof is given of the following theorem of Albert: An associative division algebra of degree 4 over its center is of order 4 in the Brauer group if and only if it cannot be written as a tensor product of quaternion algebras.
Leachability and Biodegradation of High Concentrations of Phenol and o-Chlorophenol (1993)

The treatability of phenol and o-chlorophenol by solidification/stabilization and phenol by biodegradation was investigated. The effect of two concentrations, 0.1 and 2% of contaminant in cement (equivalent to 2,000 and 40,000 ppm in water), on the setting and solidification process of Type I Portland cement was studied. Leachability of these phenolic compounds from the solidified cement matrix, cured up to 180 days, was evaluated using the U.S. EPA recommended Toxicity Characteristic Leaching Procedure (TCLP) and the American Nuclear Society's ANS 16.1 leaching test. Changes in microstructure of the cement due to the addition of phenol was studied using the X-ray diffraction technique. A power law has been proposed to quantify the phenol leached from the solidified cement matrix during the TCLP test. The phenolic compounds affected the setting time and strength of the solidified cement. Biodegradation of phenol up to 1500 ppm was investigated in batch reactors using an acclimated sludge. The activated sludge, acclimated to phenol at a concentration of 1000 ppm in a three-step process, completely degraded phenol up to 1500 ppm. Both zero and first order degradation of phenol was observed depending on the initial phenol concentration. A new model, more general form of the Haldane model, has been proposed to represent the relationship between specific growth rate and the concentration of the inhibitory substrate phenol. Biokinetic parameters for biodegrading phenol using the acclimated sludge are compared to a few other published data on phenol degradation.
Limonene chemoprevention of mammary carcinoma induction following direct in situ transfer of v-Ha-ras. (1994)

Monoterpenes, including limonene and its in vivo rat plasma metabolites, have been shown to be inhibitors of protein isoprenylation of small G proteins, including p21 ras. In addition, dietary limonene has been shown to be capable of preventing the development and causing the regression of chemically induced mammary carcinomas, many of which contain activated ras oncogenes. On the basis of these observations, it was hypothesized that a possible mechanism by which limonene exerts its effects on the chemoprevention and regression of mammary tumors involves the inhibition of protein isoprenylation of the small G protein p21. In the first study, we asked whether dietary limonene was able to prevent the development of mammary carcinomas which were induced using direct retroviral gene transfer of v-Ha-ras into the mammary parenchyma in situ. Limonene modified neither the rate of gene transfer nor the stability of gene expression. However, limonene did greatly inhibit the formation of mammary carcinomas induced by the insertion of activated ras. In a follow-up study, we asked whether chemoprevention by limonene was preferentially effective against a subset of chemically induced mammary carcinomas with activated ras. Rats were fed limonene to prevent the development of N-nitroso-N-methylurea-induced mammary tumors, a majority of which contain the activated Ha-ras oncogene. As expected, limonene administration increased the latency period and lowered the frequency of mammary carcinoma development as compared to controls. However, tumor characterization revealed that limonene treatment did not alter the percentage of carcinomas with activated ras. These studies are consistent with the above studies in that limonene is effective in preventing mammary carcinomas with activated ras. Interestingly, carcinomas without activated ras were prevented to the same extent as those with the activated oncogene.
Genetically Engineered Multivalent Proteins for Targeted Immunotherapy (2016)

mAbs initiated the unprecedented breakthroughs in cancer immunotherapy and are rapidly evolving with multiple therapeutic platforms. One next-generation strategy engineers multivalent proteins that ligate single-chain variable fragments targeting cellular effectors, tumor-associated antigens, and cytokines. These developing therapeutics target and regulate cellular effector bioactivity and significantly improve clinical outcomes. Clin Cancer Res; 22(14); 3419-21. ©2016 AACRSee related article by Vallera et al., p. 3440.
Meningococcal vaccination in adolescents and adults induces bactericidal activity against hyperinvasive complement-resistant meningococcal isolates (2022)

ABSTRACT Background Complement-mediated killing is critical in the defense against meningococci. During a recent outbreak of invasive meningococcal serogroup W disease (IMD-W) in the Netherlands, the predominant isolates belonged to clonal complex (cc) 11, which may suggest a role for cc11-assocated traits in complement resistance. We investigated complement resistance of invasive and carriage meningococcal isolates of different serogroups and lineages. In addition, we investigated whether vaccine-induced antibodies can overcome resistance to complement-mediated killing. Methods We analyzed IMD isolates (n=56) and carriage isolates (n=19) of different serogroups and clonal lineages in the serum bactericidal antibody (SBA) assay using pooled serum from unvaccinated and vaccinated individuals. Furthermore, we determined meningococcal serogroup W geometric mean titers (GMTs) and protection levels with the routinely-used non-cc11 isolate and hyperinvasive cc11 isolates using individual serum samples from adolescents and adults 5 years postvaccination. Results The hyperinvasive IMD isolates showed high variation in their resistance to complement-mediated killing when pooled serum from unvaccinated individuals was used (median 96, range 2-1,536). When pooled sera from vaccinated individuals was used, all isolates were killed. The minimum spanning tree revealed moderate clustering of serogroup and cc, while complement resistance did not. While a significantly lower GMT was observed against cc11 meningococcal serogroup W (MenW) compared to a non-cc11 MenW isolate in vaccinated adults but not in adolescents, we found no differences in the proportion protected between these isolates. Conclusions These data show that vaccine-induced antibodies are effectively inducing complement-mediated killing of complement-resistant hyperinvasive and carriage meningococcal isolates. Short summary Meningococcal isolates of hyperinvasive lineages are resistant to complement-mediated killing but vaccine-induced antibodies effectively kill these invasive isolates.