gebhart/patrepeval huggingface dataset:
The impact of recent advances in diagnostic technology on the clinical presentation of phaeochromocytoma (1992)

Advances in diagnostic technology, particularly specific adrenaline assays and computed tomography, have made possible the early diagnosis of patients with phaeochromocytoma presenting in ways previously thought to be uncommon. All patients with adrenal masses noted incidentally on CT scan should be investigated for phaeochromocytoma. Adrenaline-secreting tumours are common and both noradrenaline and adrenaline should be assayed in all patients investigated for phaeochromocytoma.
Design of parallel concatenated convolutional codes (1996)

A parallel concatenated convolutional coding scheme consists of two constituent systematic: convolutional encoders linked by an interleaver. The information bits at the input of the first encoder are scrambled by the interleaver before entering the second encoder. The codewords of the parallel concatenated code consist of the information bits followed by the parity check bits of both encoders. Parallel concatenated codes (turbo codes), decoded through an iterative decoding algorithm of relatively low complexity, have been shown to yield remarkable coding gains close to theoretical limits. We characterize the separate contributions that the interleaver length and constituent codes give to the overall performance of the parallel concatenated code, and present some guidelines for the optimal design of the constituent convolutional codes.
Pharmacologic inhibition of S-nitrosoglutathione reductase protects against experimental asthma in BALB/c mice through attenuation of both bronchoconstriction and inflammation (2014)

The significant bronchodilatory and anti-inflammatory actions of N6022 in the airways are consistent with restoration of GSNO levels through GSNOR inhibition. GSNOR inhibition may offer a therapeutic approach for the treatment of asthma and other inflammatory lung diseases. N6022 is currently being evaluated in clinical trials for the treatment of inflammatory lung disease.
Comparative Histological Subtyping of Immune Cell Infiltrates in MPO-ANCA and PR3-ANCA Glomerulonephritis (2021)

Our observations imply distinct pathomechanisms contributing to inflammation and renal injury in MPO vs. PR3-associated ANCA GN and potentially contribute to new therapeutic targets in specific ANCA subtypes.
Addressing thermal and power delivery bottlenecks in 3D circuits (2009)

The enhanced packing densities facilitated by 3D integrated circuit technology also has an unwanted side-effect, in the form of increasing the amount of current per unit footprint of the chip, as compared to a 2D design. This has ramifications on two critical issues: firstly, it means that more heat is generated per unit footprint, potentially leading to thermal problems, and secondly, more current must be supplied per package pin, leading to possible power delivery bottlenecks. This paper presents an overview of the challenges and solutions in the domain of addressing these two issues in 3D integrated circuits.
Amplicon profiling reveals cytoplasmic overexpression of MUC1 protein as an indicator of resistance to platinum-based chemotherapy in patients with ovarian cancer (2004)

Chromosomal gains of 1q21-q22 and 13q12-q14 were closely related with the chemoresistance of patients with ovarian cancer in our previous CGH (comparative genomic hybridization) study. We conducted the present study to determine the amplified genes on chromosome 1q. Comparisons of relative copy numbers of clinically platinum-sensitive ovarian tumors (CR-group, n=14) and platinum-resistant tumors (PD-group, n=14) were carried out using real-time PCR from ten different gene loci on chromosome 1q. Increased copy numbers were frequently observed in PD-group tumors, especially in the region between WI-8123 and MUC1. Relative copy number of MUC1 over 1.5 was observed in 13 (92%) of 14 PD-group tumors and 3 (21%) of 14 CR-group tumors (p<0.05). Moreover, cytoplasmic expressions of MUC1 protein were significantly higher in PD-group than those in CR-group (p<0.01). We concluded that the cytoplasmic overexpression of MUC1 might be an indicator of resistance to platinum-based chemotherapy and a prognostic marker in ovarian cancer.
ChemInform Abstract: Enhanced Biodegradation of Pesticides in the Environment (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Heterolytic Cleavage of Dihydrogen by Ruthenium and Molybdenum Complexes (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Development and evaluation of a system that executes an interventional cardiology risk model based on patient phenotypes automatically extracted from the EMR (2020)

Lack of electronic medical record (EMR) integration hampers effective clinical operationalization of clinical decision support. Accordingly, this study sought to develop and evaluate a system that automatically executes an interventional cardiology risk model based on EMR content accessed through a web service. Phenotyping rules were developed to automatically determine the models risk factors, advanced age, anemia, congestive heart failure, diabetes, reduced eGFR and hypotension. Performance of the rules was determined using a ground truth based on chart review of 76 patients. Except for one instance, PPV and NPV of the phenotyping rules exceeded 0.93. The predictions produced by the risk model were accurate in 82% of patients. Performance of the phenotyping rules was determined by the ability to model the rules after the risk model's definition and the availability and accuracy of the accessed data sources. Data retrieved by the rules can be presented for efficient physician review and confirmation.
Transition layers in metal bilayers produced by pulsed laser deposition in vacuum (2002)

Main processes which accompany the interaction of energetic particles with the substrate and the growing film in the pulsed laser deposition (PLD) in vacuum are considered. The subplantational film growth mode, which is inherent to PLD, results in the formation of diffuse transition layers (TLs) between the individual materials of the substrate and film. It is argued that thermodynamic forces do not play a significant role in formation of TLs at room temperature by PLD in vacuum, and the resulting concentration profile between the individual materials is determined almost purely by ballistic effects. Up to 10 nm thick TLs in Fe/Al and Ag/Co PLD-produced bilayers have been determined by numerical simulations, semiquantitative analysis and experimentally by means of a quartz thickness monitor. The latter technique has been proposed as an in situ method for determination of TLs between the individual materials with different sputtering yields. The concentration profiles of TLs are featured by a steep slope on the substrate side and an up to 10 nm long tail of the underlying material in the upper layer.
Towards a Framework for Changing-Contact Robot Manipulation (2021)

Many robot manipulation tasks require the robot to make and break contact with objects and surfaces. The dynamics of such changing-contact robot manipulation tasks are discontinuous when contact is made or broken, and continuous elsewhere. These discontinuities make it difficult to construct and use a single dynamics model or control strategy for any such task. We present a framework for smooth dynamics and control of such changing-contact manipulation tasks. For any given target motion trajectory, the framework incrementally improves its prediction of when contacts will occur. This prediction and a model relating approach velocity to impact force modify the velocity profile of the motion sequence such that it is $C^\infty$ smooth, and help achieve a desired force on impact. We implement this framework by building on our hybrid force-motion variable impedance controller for continuous contact tasks. We experimentally evaluate our framework in the illustrative context of sliding tasks involving multiple contact changes with transitions between surfaces of different properties.
Experimental treatment of Staphylococcus aureus bovine intramammary infection using a guanine riboswitch ligand analog (2012)

Staphylococcus aureus is a leading cause of intramammary infections (IMI). We recently demonstrated that Staph. aureus strains express the gene guaA during bovine IMI. This gene codes for a guanosine monophosphate synthetase and its expression is regulated by a guanine riboswitch. The guanine analog 2,5,6-triaminopyrimidine-4-one (PC1) is a ligand of the guanine riboswitch. Interactions between PC1 and its target result in inhibition of guanosine monophosphate synthesis and subsequent death of the bacterium. The present study describes the investigational use of PC1 for therapy of Staph. aureus IMI in lactating cows. The in vitro minimal inhibitory concentration of PC1 ranged from 0.5 to 4 μg/mL for a variety of Staph. aureus and Staphylococcus epidermidis strains and required a reducing agent for stability and full potency. A safety assessment study was performed, whereby the healthy quarters of 4 cows were infused with increasing doses of PC1 (0, 150, 250, and 500 mg). Over the 44 h following infusions, no obvious adverse effect was observed. Ten Holstein multiparous cows in mid lactation were then experimentally infused into 3 of the quarters with approximately 50 cfu of Staph. aureus strain SHY97-3906 and infection was allowed to progress for 2 wk before starting PC1 treatment. Bacterial counts reached then about 10(3) to 10(4) cfu/mL of milk. Infected quarters were treated with 1 of 3 doses of PC1 (0, 250, or 500 mg) after each morning and evening milking for 7d (i.e., 14 intramammary infusions of PC1). During the treatment period, milk from PC1-treated quarters showed a significant reduction in bacterial concentrations. However, this reduction of Staph. aureus count in milk was not maintained during the 4 wk following the end of the treatment and only 15% of the PC1-treated quarters underwent bacteriological cure. The somatic cell count and the quarter milk production were not affected by treatments. Although bacterial clearance was not achieved following treatment with PC1, these results demonstrate that the Staph. aureus guanine riboswitch represents a relevant and promising drug target for a novel class of antibiotics for the animal food industry.
Initial Operation and Calibration of the SOLIS Vector Spectromagnetograph (2003)

The National Solar Observatory's SOLIS Vector Spectromagnetograph (VSM) is designed to observe the Sun's vector magnetic field over the entire visible disk several times per day for at least two decades and will provide important new information about the drivers of CMEs and other s o l a r activity affecting the heliosphere. The VSM is being prepared for temporary installation at the agricultural site of the University of Arizona. We report on the status of the instrument, emphasizing early data and their comparison with observations from the NASA/NSO Spectromagnetograph at the Kitt Peak Vacuum Telescope and the HAO/NSO Advanced Stokes Polarimeter at the Sacramento Peak Dunn Vacuum Tower Telescope.
Thermo-mechanical design of fan-out wafer level package for power converter module (2017)

In this paper, thermo-mechanical simulations including wafer level warpage, thermal cycle and power cycle were conducted for the fan-out wafer level package (FOWLP) test vehicle of power converter module. From the simulation results, the wafer level warpage of 8 inch molded wafer can achieve the warpage target of lower than 1mm during the process flow from after molding, after back side grinding to after RDL fabrication with low CTE epoxy molding compound (EMC). The simulation results also demonstrated that the solder joints can pass 1000 thermal cycles with the loading of -65°C-150 °C. EMC with higher CTE can help to enhance the reliability of solder joints between the package\PCB. But the usage of the higher CTE EMC was limited by the wafer level warpage requirement. The power cycle simulation results demonstrated that the proposed FOWLP test vehicle for the power converter module can pass 10 K power cycles with junction temperature variation range of ΔT=100 °C.
Transcriptome and metabolome analysis in shoot and root of Valeriana fauriei (2016)

We have identified the transcriptome using Illumina HiSeq system in shoot and root of V. fauriei. Also, we have demonstrated gene expressions associated with secondary metabolism such as terpenoid, carotenoid, and phenylpropanoid.
Regulation of Respiration and Apoptosis by Cytochrome c Threonine 58 Phosphorylation (2019)

Cytochrome c (Cytc) is a multifunctional protein, acting as an electron carrier in the electron transport chain (ETC), where it shuttles electrons from bc<sub>1</sub> complex to cytochrome c oxidase (COX), and as a trigger of type II apoptosis when released from the mitochondria. We previously showed that Cytc is regulated in a highly tissue-specific manner: Cytc isolated from heart, liver, and kidney is phosphorylated on Y97, Y48, and T28, respectively. Here, we have analyzed the effect of a new Cytc phosphorylation site, threonine 58, which we mapped in rat kidney Cytc by mass spectrometry. We generated and overexpressed wild-type, phosphomimetic T58E, and two controls, T58A and T58I Cytc; the latter replacement is found in human and testis-specific Cytc. In vitro, COX activity, caspase-3 activity, and heme degradation in the presence of H<sub>2</sub>O<sub>2</sub> were decreased with phosphomimetic Cytc compared to wild-type. Cytc-knockout cells expressing T58E or T58I Cytc showed a reduction in intact cell respiration, mitochondrial membrane potential (∆Ψ<sub>m</sub>), ROS production, and apoptotic activity compared to wild-type. We propose that, under physiological conditions, Cytc is phosphorylated, which controls mitochondrial respiration and apoptosis. Under conditions of stress Cytc phosphorylations are lost leading to maximal respiration rates, ∆Ψ<sub>m</sub> hyperpolarization, ROS production, and apoptosis.
Handover Scheme Using Downlink and Uplink Signals (2008)

This paper proposes a handover scheme using uplink and downlink signals in IEEE 802.16e systems. Exploiting the channel reciprocity in TDD systems, the proposed scheme triggers handover initiation process using uplink signal. In addition, it exploits the uplink and downlink hysteresis to determine the handover direction. Simulation results show that the proposed algorithm with joint hysteresis reduces the outage probability by about 10% compared with the mobile assisted handover in IEEE 802.16e.
Eco-conception : de nouveaux critères de conception en électrotechnique pour le développement durable (2010)

National audience
The structure of crotonitenone, a novel casbane diterpene from Croton nitens Sw. (Euphorbiaceae) (1981)

A novel casbane diterpene, crotonitenone {(E)-(1R*,5S*,7R*,11S*,14S*)-5-hydroxy-3,7,11,15,15-pentamethylbicyclo[12.1.0]pentadec-2-ene-4,8-dione}(7), C20H32O3, has been isolated from Croton nitens(Euphorbiaceae) and its structure and relative stereochemistry have been established by chemical, spectral, and X-ray crystallographic means. Crystals of (7) are monoclinic, space group P21, with a= 12.446(1), b= 13.285(1), c= 5.872(1)Å, β= 97.02(1)°, and Z= 2. The structure was refined by least squares to R 0.040 and R′ 0.038.
Nanophotonic code embedded in embossed hologram for hierarchical information retrieval (2010)

A hierarchical hologram works in both optical far-fields and near-fields, the former being associated with conventional holographic images, and the latter being associated with the optical intensity distribution based on a nanometric structure that is accessible only via optical near-fields. We propose embedding a nanophotonic code, which is retrievable via optical near-field interactions involving nanometric structures, within an embossed hologram. Due to the one-dimensional grid structure of the hologram, evident polarization dependence appears in retrieving the code. Here we describe the basic concepts, numerical simulations, and experimental results in fabrication of a prototype hierarchical hologram and describe its optical characterization.
Laser-induced changes in the dispersive properties ofp−Gedue to intervalence-band transitions (1981)

We present a theory describing the laser-induced change in the real part of the complex dielectric constant in $p\ensuremath{-}\mathrm{G}\mathrm{e}$ that results from saturation of the intervalence-band transitions. Calculations are performed for room temperature and for light with a wavelength of 10.6 \ensuremath{\mu}m. The real part of the dielectric constant is found to increase monotonically with increasing intensity. The magnitude of the increase is directly proportional to the density of free holes. The intervalence-band contribution to the first-order modification of the real part of the dielectric constant equals the intrinsic contribution at a doping level of about 3\ifmmode\times\else\texttimes\fi{}${10}^{15}$ ${\mathrm{cm}}^{\ensuremath{-}3}$.
Experimental study of electro-plastic effect on advanced high strength steels (2013)

Abstract Application of Advanced High Strength Steels (AHSS) into vehicle structures calls for innovative manufacturing processes. In terms of reducing deformation resistance through external energy, Electro-Plastic Effect (EPE) provides a potential alternative to traditional thermal softening phenomenon. In this work, effectiveness of EPE on one group of AHSS, Transformation Induced Plasticity (TRIP) Steel, was evaluated. It was found that EPE cannot be effectively initiated until the current density reaches a threshold value between 7.4 A/mm2 and 11.4 A/mm2. Besides, the softening phenomenon is more distinct at larger strains. Underlying mechanisms are explained from perspectives of dislocation multiplication, gliding and mechanical twinning. The inevitable Joule heating phenomenon associated with current was suppressed with forced air cooling and the temperature distribution inside the tensile specimen was numerically calculated with a coupled Finite Element Model. Effectiveness of EPE rather than thermal softening or expansion was further proved with the larger flow stress reduction under higher current density and shorter pulses at same temperature increase. Hollomon equation was adopted to model the observed stress strain relationships. Since material properties of TRIP steels are directly related to the phase transformation from retained austenite into martensite, volume fraction of retained austenite was quantitatively measured by X-ray Diffraction (XRD). It was found that the applied current retarded martensitic transformation process. Metallographic analysis was further performed and phenomena of change of grain structures and phase distribution were hardly observable.
Application of the RASTAR Method to Continuous Scanning LDV Measurements (2021)

This paper presents the application of RASTAR method to diagnostics performed by continuous scanning spectral sidebands. In a previous investigation, RASTAR proved to detect damage condition of a cantilever beam which was continuously scanned along a line by a laser beam. The objective of this paper is to extend the method to two-dimensional scan rather than one. As the method is based on spectral sidebands, the access to spectral lines for deflections in both directions in space should enhance the detection of damage for structures which are lookalike panels. The research is focused on numerical simulations where the LDV was synthesized using continuous scanning approach. The results are encouraging and show that two-dimensional scans can be more useful for RASTAR to detect damage.
Ring Expansion of Heterocyclic Ketene N,X‐Acetals and 2‐Alkylidenedihydroindoles with Methanesulphonyl Azide by [3 + 2] Cycloaddition and Subsequent Extrusion of Molecular Nitrogen (1996)

Abstract Methanesulphonyl azide ( 2 ) reacts readily with isolated cyclic ketene N,X ‐acetals of type 1 , viz. 10a, d, 15b, d , and 22a–c , or those that are generated in situ by deprotonation of the corresponding 2‐alkylbenzazolium tetrafluoroborates, i.e. 14a → 15a, 14b → 15b , and 18 → 19 . Ring‐expanded products are formed by extrusion of molecular nitrogen from intermediate labile [3 + 2] cycloadducts 3 with concomitant 1,2‐shift of N (route A1 → 12, 24 ) or X (route A2 → 16, 20, 21 ). In addition, 3 may undergo [3 + 2] cycloreversion into N ‐sulphonylimine 5 and diazoalkane 6 (route B → 13, 17, 25 ). The configurations of the cyclic N ‐sulphonylamidines 16b and 21b , the N ‐sulphonylimine 24 and the N ‐sulphonylamine 27 are elucidated by means of X‐ray diffraction analyses. The ratio of the (useful) ring‐expansion reactions vs. the unwanted formation of 5 + 6 is hardly influenced by the solvent employed and temperature of the experiment but strongly by the nature of the potential migrating atom and the substituents at the α‐carbon atom.
Highly Active PdCu Alloy Nanowire Network Electrocatalyst for Ethanol and Methanol Electrooxidation (2017)

Abstract PdCu alloy nanowire networks (NNWs) with tunable compositions are synthesized. Electrooxidaton catalytic measurements prove that the as‐prepared PdCu NNWs represent a predominant catalyst for methanol and ethanol electrooxidation reactions in alkaline medium. With increasing copper content, the electrocatalytic activity of the catalytic materials to ethanol and methanol was significantly increased. Pd 27 Cu 73 NNW‐modified electrodes display superior catalytic activity (8300 A g Pd −1 ) toward the ethanol electrooxidation compared to commercial Pd/C‐modified electrodes (700 A g Pd −1 ). PdCu NNWs have great potential as electrocatalysts for fuel cells.
Ultrastructural immunocytochemical studies of the localization and distribution of somatostatin, calcitonin, calcitonin gene‐related peptide, and substance p in the bat thyroid follicle (1988)

Electron microscope immunocytochemistry was used to determine the intracellular localization and distribution among follicular elements of four peptides: calcitonin, somatostatin, calcitonin gene-related peptide (CGRP), and substance P in the thyroid glands of bats captured in the prehibernation phase of their annual life cycle. Previous studies have shown that this period of the hibernation-activity cycle is characterized by the accumulation and storage of secretory granules in parafollicular cells. Sites of binding of primary antisera to each of the four peptides were identified by means of affinity-purified secondary antisera directly coupled to colloidal gold particles. Calcitonin and somatostatin immunoreactivities were found in all parafollicular cells examined and in every secretory granule within these cells. CGRP was also found in all parafollicular cells examined (n = 75) but only in about half of their secretory granules. In contrast to these peptides, substance P immunoreactivity was not found in any parafollicular cells, but was localized exclusively in nerve endings within the basement membrane of the follicle.