gebhart/patrepeval huggingface dataset:
Instrumented infrastructures for damage detection and management (2017)

The Authorities that are responsible for the design and management of infrastructures have an increasing need of information and support in order to optimize their work, save money, time, and, sometimes (e.g., in case of disastrous events), lives. Technological development is leading to new possibilities, in terms of new technologies increasingly available, widespread, reliable and inexpensive and that can be applied to make smart cities safer and more efficient. Hence, new methods and devices may be thought out in order to respond to these requests and to help Authorities during the structural health assessment/monitoring (SHA/SHM) of infrastructures and also during the emergency management. To this end, in this paper a new SMA/SHM method is proposed and validated through experimental investigations. The new proposed method is based on the vibro-acoustic response of a transportation infrastructure and pertains to its SHA/SHM. The method builds on using the road traffic noise as source of vibrations and sounds. Microphones are placed in different positions (in drilled holes and/or on the upper surface: receiver), and vibro-acoustic signals are recorded. The spectra of these signals are expected to represent the vibro-acoustic signature of the road pavement under investigation. From the analysis of this signature, information about the presence and the severity of cracks into the layers of the road section can be derived. In the pursuit of the method validation, non-destructive on-site tests, aimed at classifying the level of damage through high-speed devices/methods (i.e., visual detection of surface distress, moduli estimation through the light falling weight deflectometer (LWD), laser detection of roughness), were carried out. Road pavements in different structural conditions were investigated. From the analysis of the gathered acoustic signatures, the identification and localization of cracks into the pavements under investigation was carried out. These results are going to be used to set up a preliminary database of acoustic signature of different road pavements. Further applications of the new method are expected for a large number of road infrastructures, aiming at enriching the abovementioned database and improving predictive algorithms. Based on the proposed method, it is expected: i) to make available an estimation of the level of integrity of a road pavement to use in the management of transportation infrastructure for better, safer, and more economical smart cities and roads; ii) to provide a fast, inexpensive, and useful tool for the authorities that are responsible for the management of road infrastructures and other civil infrastructures in smart cities; iii) to provide a tool for delivering essential services to citizens.
Solubility Determination and Correlation of Warfarin Sodium 2-Propanol Solvate in Pure, Binary, and Ternary Solvent Mixtures (2019)

The solubility of warfarin sodium isopropanol solvate (WS·IPA), a widely used anticoagulant, was determined at temperatures ranging from 278.15 to 333.15 K in four pure solvents (acetone, ethanol, IPA, and water), five binary solvent mixtures (IPA + acetone, IPA + ethanol, IPA + water, IPA + heptane, and IPA + hexane), and five ternary solvent mixtures (IPA + acetone + heptane, IPA + acetone + hexane, IPA + ethanol + heptane, IPA + ethanol + hexane, and IPA + water + heptane) using the polythermal method. It was demonstrated that the solubility of WS·IPA increases with increasing temperature in the pure solvents and at constant solvent composition in the solvent mixtures. In addition, the solubility of WS·IPA in IPA increases with increasing content of acetone, ethanol, and water, which act as cosolvents, and decreases with increasing content of heptane and hexane, which act as antisolvents. The experimental solubility data of WS·IPA in pure solvents and binary and ternary solvent mixtures were correlated using the modified Apelblat and <i>λ</i>h model equations. The correlated solubility data agree with the experimental data based on the relative deviation and the average relative deviation (ARD %) values. Thus, the correlated and experimentally derived solubility data of WS·IPA provide a pathway to engineer advanced pharmaceutical crystallization processes for WS·IPA.
Increased cerebrospinal fluid albumin and immunoglobulin A fractions forecast cortical atrophy and longitudinal functional deterioration in relapsing-remitting multiple sclerosis (2017)

CSF markers of blood-brain barrier integrity and specific immune response forecast emerging gray matter pathology and disease progression in MS.
Food and Agricultural Biotechnology: An Overview (1996)

Biotechnology is an invaluable process for the quick, safe, and precise transfer of specific genetic information from one organism to another, in order to create predictable end results. As such, biotechnology represents a tool that is an important component of a balanced, efficient, well-managed, and environmentally responsible agricultural system, which uses the very best of technology and science. Recent discoveries in the field of biotechnology have made the life sciences some of the most exciting fields of scientific endeavor--especially for those with creativity and vision. This overview provides a "sampling" of how biotechnology will impact global agriculture, and hence, the world population of the third millennium.
Uniform Resource Locators (1995)

Click to increase image sizeClick to decrease image size Additional informationNotes on contributorsMark Hahn Mark Hahn is an independent information systems auditing and security consultant based in Studio City CA. He specializes in information systems audit and security administration issues related to MVS, VM, and TSO installations. Hahn has written and lectured extensively on various aspects of operating system tuning, performance, and security. The author invites the reader to visit his WWW home page at URL:http://www.wp.com/MHAHNBE or to send E-mail messages to him at hahnbe@pobox.com.
Intravitreal administration of recombinant human opticin protects against hyperoxia-induced pre-retinal neovascularization (2021)

Opticin is an extracellular glycoprotein present in the vitreous. Its antiangiogenic properties offer the potential for therapeutic intervention in conditions such as proliferative diabetic retinopathy and retinopathy of prematurity. Here, we investigated the hypothesis that intravitreal administration of recombinant human opticin can safely protect against the development of pathological angiogenesis and promote its regression. We generated and purified recombinant human opticin and investigated its impact on the development and regression of pathological retinal neovascularization following intravitreal administration in murine oxygen-induced retinopathy. We also investigated its effect on normal retinal vascular development and function, following intravitreal injection in neonatal mice, by histological examination and electroretinography. In oxygen-induced retinopathy, intravitreal administration of human recombinant opticin protected against the development of retinal neovascularization to similar extent as aflibercept, which targets VEGF. Opticin also accelerated regression of established retinal neovascularization, though the effect at 18 h was less than that of aflibercept. Intravitreal administration of human recombinant opticin in neonatal mice caused no detectable perturbation of subsequent retinal vascular development or function. In summary we found that intraocular administration of recombinant human opticin protects against the development of pathological angiogenesis in mice and promotes its regression.
Identification of ITPA on chromosome 20 as a susceptibility gene for young-onset tuberculosis (2016)

Tuberculosis (TB) is a complex disease, and both genetic and environmental factors contribute to disease progression. A previous genome-wide linkage study in Thailand determined that chromosome 20p13-12.3 may contain risk factors for young-onset disease. The present study aimed to identify novel susceptibility genes for young-onset TB within a 1-Mbp target region adjacent to the top-ranking risk marker in Chr.20p13-12.3. We performed next-generation sequencing (NGS) of the region in 13 young patients from multi-case families in Thailand. We then selected the functionally interesting single-nucleotide polymorphisms as candidates for subsequent analyses. The detected candidates rs13830 and rs1127354 in ITPA showed an association with young (<45 years old) TB patients. However, there was no association in old (⩾45 years old) patients. These findings confirm that stratifying patients based on age of TB onset can be important for identifying genetic risk factors for TB susceptibility. In addition, in silico expression quantitative trait loci analyses indicated that ITPA expression was associated with rs13830 genotype. This is the first study to use NGS resequencing to gain insight into host genetic factors associated with TB and to report a significant association for ITPA with host susceptibility in young-onset TB. The study also demonstrated the effectiveness of NGS in identifying susceptibility genes in common diseases.
Corrigendum: Molybdenum Imido Alkylidene N‐Heterocyclic Carbene Complexes: Structure–Productivity Correlations and Mechanistic Insights (2020)

This is a Corrigendum for the article entitled “Molybdenum Imido Alkylidene N-Heterocyclic Carbene Complexes: Structure-Activity Correlations and Mechanistic Insights”, published in ChemCatChem 2016, 8, 2710–2723, DOI: 10.1002/cctc.201600624. After publication, the authors noticed a discrepancy in the ordering of the graphics, which appears to have been introduced by the editorial office. Additionally, there are some other small corrections, which are added here for accuracy. The conclusions and the discussion related to this paper remain unaffected. The editorial office and the authors apologize for this oversight. The figure graphics are out of sequence, however the captions are in order. The graphic above figure caption “Figure 3” must be replaced by the graphic above figure caption “Figure 8” The graphic above figure caption “Figure 4” must be replaced by the graphic above figure caption “Figure 3” The graphic above figure caption “Figure 5” must be replaced by the graphic above figure caption “Figure 4” The graphic above figure caption “Figure 6” must be replaced by the graphic above figure caption “Figure 5” The graphic above figure caption “Figure 7” must be replaced by the graphic above figure caption “Figure 6” The graphic above figure caption “Figure 8” must be replaced by the graphic above figure caption “Figure 7” The values for OTf-Mo-NAr', for 4, 11, and 12 are corrected for Table 1. Compound 10 (Figure 5) rather crystallizes in the monoclinic space group P21c. The CCDC number assigned to 4 should be 1453110. Complex 1 4 9 10 11 12 14 16 17 18 OTf-Mo-NAr′ 169.77 131.20 160.57 162.87 88.43 167.76 – 94.10 91.07 –
Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu (2002)

Overexpression of the transmembrane receptor tyrosine kinase ErbB2 is common in multiple malignancies, including breast and ovarian cancer. ErbB2 is resistant to degradation mediated by c-Cbl, the E3 ubiquitin ligase responsible for ligand-induced ubiquitination of ErbB1 (epidermal growth factor receptor). Because of its resistance to degradation, ErbB2 is the preferred dimerization partner for other members of the ErbB family, and its overexpression in vivo is associated with poor prognosis. We now show that the chaperone-binding ubiquitin ligase CHIP efficiently ubiquitinates and down-regulates ErbB2. CHIP expression shortens the half-life of both nascent and mature ErbB2 protein. In vitro ubiquitination assay shows that CHIP serves as a ubiquitin ligase for ErbB2, and both exogenously expressed and endogenous CHIP coprecipitate with the kinase. Furthermore, CHIP association with ErbB2 requires a chaperone intermediate and is increased by the chaperone-binding drug geldanamycin, a potent stimulator of ErbB2 ubiquitination and degradation. These data describe a previously unrecognized pathway, amenable to pharmacologic manipulation, that mediates ErbB2 stability.
System and algorithms for an autonomous observatory assisting the search for the Ivory-Billed Woodpecker (2008)

Ornithologists, conservationists, and millions of birdwatchers consider the Ivory-Billed Woodpecker (IBWO) the ‘Holy Grail of Birds.’ There have been hundreds of reports of sightings of this magnificent bird but no conclusive photo has been recorded since 1948. Under our broader research effort to develop networked autonomous “observatories” for natural environments, we have been working with the Cornell University researchers who have led a massive search initiated by eyewitness reports and low resolution video captured in the Cache River National Wildlife Refuge of Arkansas. In this paper we describe the two-camera autonomous observatory system we designed and installed in Arkansas that continuously scans the sky, recording high resolution video of candidate birds. We report on hardware, software, and algorithms based on 15 months of field experiments. Our image processing algorithm combines size filtering, nonparametric motion filtering, and temporal difference filtering to detect flying birds. Initial results suggest that we have met our four design goals: sensitivity, data reduction, accuracy, and robustness. Video segments with several bird species have been conclusively identified, video data has been consistently reduced by 99.9953%, the system is able to capture birds flying at a speed of up to 60km per hour with low false negative rates, and the system has held up to harsh field conditions. For latest updates and samples of video, please see http://www.c-o-n-e.org/acone/.
Why Sepsis Trials Fail (1996)

FEW CRITICAL conditions in medicine are as paradoxical as the events occurring during sepsis. The response of the patient's body to an insult such as infection or severe injury may initially be appropriate, but such defenses can lose their usual balance and destroy the patient. If the defense forces could be down-regulated after they have responded to the initial insult but before they begin destroying the body itself, we could prevent sepsis from developing—or at least reduce the associated mortality. Deceptively simple, a viable way to accomplish this downregulation has eluded intense clinical research scrutiny for more than 10 years. All the trials of new therapies for sepsis conducted to date have failed to show efficacy (Table). Conducted under the rigorous conditions of the double-blind, randomized, placebo-controlled trial, their uniformly negative results have provoked great disappointment. I believe the trials have reached the correct conclusion. The problem has not been
A software assistant for the design and analysis of neuromuscular tests (2007)

An interactive software assistant (SimScript) has been developed to help in the design of neuromuscular tests and in the analysis of data gathered from these tests. The tool is based on the Kinematic Theory of rapid human movements and its Sigma-Lognormal ( <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">→</sup> ΣΛ) model. It allows the manipulation of the movement kinematics using analytical expressions. Although the project is still exploratory, current work focuses on three long term objectives: improvement of clinical rehabilitation results from stroke-impaired patients, lowering medical cost by helping in the development of at-home rehabilitation exercises and the development of a deeper understanding of the human neuromuscular kinematics properties. This paper briefly summarizes the <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">→</sup> ΣΛ model, presents the properties and possibilities of SimScript and presents an example of practical application.
Medpor® regulates osteoblast's microRNAs (2008)

Porous polyethylene (PP or Medpor) is an alloplastic material worldwide used for craniofacial reconstruction. Although several clinical studies are available, there is a lack as regard the genetic effects. Because PP is always fixed on bone and the mechanism by which PP acts on osteoblasts is unknown, we therefore attempted to address this question by using microRNA microarray techniques to investigate the translation regulation in osteoblasts exposed to PP. The miRNA oligonucleotide microarray provides a novel method to carry out genome-wide microRNA profiling in human samples. By using miRNA microarrays containing 329 probe designed from Human miRNA sequence, we identified in osteoblast-like cells line (MG-63) cultured with Medpor (Porex Corporation, Fairburn, Georgia, USA) several miRNA which expression is significantly modified. We identified 16 up-regulated miRNA (i.e. mir-337, mir-515-3p, mir-377, mir-153, mir-367, mir-152, let-7b, mir-92, mir-155, mir-424, mir-148b, mir-368, mir-18b, mir-520d, mir-20b, mir-128a) and 2 down-regulated miRNA (i.e. mir-143, mir-32). The data reported are, to our knowledge, the first study on translation regulation in osteoblasts exposed to PP. They can be relevant to better understand the molecular mechanism of bone regeneration and as a model for comparing other materials with similar clinical effects.
Solid-State Reactions between Picric Acid and Naphthols (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolid-State Reactions between Picric Acid and NaphtholsR. P. Rastogi and N. B. SinghCite this: J. Phys. Chem. 1966, 70, 10, 3315–3324Publication Date (Print):October 1, 1966Publication History Published online1 May 2002Published inissue 1 October 1966https://pubs.acs.org/doi/10.1021/j100882a047https://doi.org/10.1021/j100882a047research-articleACS PublicationsRequest reuse permissionsArticle Views278Altmetric-Citations56LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Numerical investigation of the three-dimensional development in boundary-layer transition (1990)

A numerical method for solving the complete Navier-Stokes equations for incompressible flows is introduced that is applicable for investigating three-dimensional transition phenomena in a spatially growing boundary layer. Results are discussed for a test case with small three-dimensional disturbances for which detailed comparison to linear stability theory is possible. The validity of our numerical model for investigating nonlinear transition phenomena is demonstrated by realistic spatial simulations of the experiments by Kachanov and Levchenko1 for a subharmonic resonance breakdown and of the experiments of Klebanoff et al.2 for a fundamental resonance breakdown.
Vereinfachtes Verfahren zur Gewinnung von humanem Albumin und γ‐Globulin aus Blutplasma mittels Alkoholfällung (1954)

Abstract A modification of Cohn 's Method 10 for the fractionation of citrated human plasma is described. Albumin and γ‐globulin can be obtained in almost the same purity as by Methods 6 and 9, but with a simpler procedure and higher yields.
Bim expression in endothelial cells and pericytes is essential for regression of the fetal ocular vasculature (2017)

Apoptosis plays a central role in developmental and pathological angiogenesis and vessel regression. Bim is a pro-apoptotic Bcl-2 family member that plays a prominent role in both developmental and pathological ocular vessel regression, and neovascularization. Endothelial cells (EC) and pericytes (PC) each play unique roles during vascular development, maintenance and regression. We recently showed that germline deletion of Bim results in persistent hyaloid vasculature, increased retinal vascular density and prevents retinal vessel regression in response to hyperoxia. To determine whether retinal vascular regression is attributable to Bim expression in EC or PC we generated mice carrying a conditional Bim allele (BimFlox/Flox) and VE-cadherin-cre (BimEC mice) or Pdgfrb-cre (BimPC mice). BimEC and BimPC mice demonstrated attenuated hyaloid vessel regression and postnatal retinal vascular remodeling. We also observed decreased retinal vascular apoptosis and proliferation. Unlike global Bim -/- mice, mice conditionally lacking Bim in EC or PC underwent hyperoxia-mediated vessel obliteration and subsequent retinal neovascularization during oxygen-induced ischemic retinopathy similar to control littermates. Thus, understanding the cell autonomous role Bim plays in the retinal vascular homeostasis will give us new insight into how to modulate pathological retinal neovascularization and vessel regression to preserve vision.
Numerical Modelling of Multilayered Coatings – Latest Developments and Applications (2014)

The remarkable mechanical properties of multilayered coatings, such as super-hardness, excellent resistance against cracking, low wear-rate and high thermal-stability, are due to their unique interfacial structures and deformation mechanisms at the nanometer scale. The multilayered coating process itself is a typical multi-scale phenomenon. The modelling of multilayered coatings has become an important topic in research recently, largely due to the recent progress that has been made in the numerical modelling of materials and structures at different length-scales as well as the improved effectiveness achieved in linking such progress in numerical modelling to enable multi-scale modelling. In this paper, numerical modelling for the analysis of multilayered coatings at individual length-scales: Continuum, Molecular and Nano-scale, is reviewed, along with that at multi-scale modelling. Examples are presented showing numerical models obtained using: the Finite Element Method (FEM), Molecular Dynamics (MD), First-principles calculations and Multi-scale modelling, are presented. Their relative limitations are discussed and challenges to their future work highlighted.