gebhart/patrepeval huggingface dataset:
Improving Biogas Separation and Methane Storage with Multilayer Graphene Nanostructure via Layer Spacing Optimization and Lithium Doping: A Molecular Simulation Investigation (2012)

Methane is a desirable alternative to conventional fossil fuels, and also a main component of biogas from anaerobic fermentation of organic wastes. However, its relatively lower purity and poor storage by existing adsorbent materials negatively affect its wide application. Thus, efficient, cost-effective, and safe adsorbent materials for methane purification and storage are highly desired. In this study, multilayer graphene nanostructures (MGNs) with optimized structure are investigated as a potential adsorbent for this purpose. The effects of layer distance and Li doping on MGN performance in terms of methane storage and acid gas (H(2)S and CO(2)) separation from biogas are examined by molecular simulations. The mechanisms for the interactions between gas molecules and substrates are elucidated by analyzing the binding energy, geometric structures, and charge distribution from the first-principles calculations. The results show that nonhydrocarbons in biogas can be effectively separated using Li-doped MGNs with the optimal layer distance of 0.68 nm, and then the pure methane gas can be stored in MGNs with capacity satisfying the DOE target. This work offers a molecular-level insight into the interactions between gas molecules and MGNs and might provide useful information for development of new materials for methane purification and storage.
Synthesis and Cycloaddition Reaction of a Nitrogen-bridged Tetravalent Sulfer Compound 1,3,6-Triphenylimidazo[1,2-c]thiazole (1984)

A novel tetravalent sulfur compound. 1.3.6-triphenylimidazoI 1.2-clthiazole 1, was syntheslzed.The compound 1 reacted with N-(p-tolyllmaleimide as both an ammethine ylide and a thiocarbonyl ylide 1.3-dipole yielding four 1 :1 adducts that contained each endo and exo isomers.The cycloadducts
Imaging the Distribution of Melanin in Human Skin Lesions with Pump-Probe Microscopy (2011)

Melanoma diagnosis poses tremendous challenges in dermatopathology; recent studies show discordance rates in pathology as high as one in seven[1], and the severe consequences of missing a melanoma diagnosis has increased the number of biopsies taken and lowered the threshold for diagnosis of early melanoma[2]. This leads to unknown but likely significant societal costs and morbidity from associated unnecessary treatments.
Structural Characterization of the Mycobacterium tuberculosis Biotin Biosynthesis Enzymes 7,8-Diaminopelargonic Acid Synthase and Dethiobiotin Synthetase, (2010)

Mycobacterium tuberculosis (Mtb) depends on biotin synthesis for survival during infection. In the absence of biotin, disruption of the biotin biosynthesis pathway results in cell death rather than growth arrest, an unusual phenotype for an Mtb auxotroph. Humans lack the enzymes for biotin production, making the proteins of this essential Mtb pathway promising drug targets. To this end, we have determined the crystal structures of the second and third enzymes of the Mtb biotin biosynthetic pathway, 7,8-diaminopelargonic acid synthase (DAPAS) and dethiobiotin synthetase (DTBS), at respective resolutions of 2.2 and 1.85 A. Superimposition of the DAPAS structures bound either to the SAM analogue sinefungin or to 7-keto-8-aminopelargonic acid (KAPA) allowed us to map the putative binding site for the substrates and to propose a mechanism by which the enzyme accommodates their disparate structures. Comparison of the DTBS structures bound to the substrate 7,8-diaminopelargonic acid (DAPA) or to ADP and the product dethiobiotin (DTB) permitted derivation of an enzyme mechanism. There are significant differences between the Mtb enzymes and those of other organisms; the Bacillus subtilis DAPAS, presented here at a high resolution of 2.2 A, has active site variations and the Escherichia coli and Helicobacter pylori DTBS have alterations in their overall folds. We have begun to exploit the unique characteristics of the Mtb structures to design specific inhibitors against the biotin biosynthesis pathway in Mtb.
Digital tuning of high-order high-Q continuous-time filters (2002)

A digital tuning scheme for automatic tuning of high-order high-Q continuous-time filters is proposed. The scheme uses phase information for both centre frequency and Q tuning, and does not rely on the relation between the passband gain and Q factor. Digital control of frequency and Q tuning loops improves the stability by enabling only one loop at a given tuning cycle. High-order filter tuning is performed without separating individual sections, eliminating switches and their parasitics.
Video surveillance for aircraft activity monitoring (2006)

This paper presents a complete visual surveillance system for the automatic scene interpretation of airport aprons. The system comprises two modules scene tracking and scene understanding. The scene tracking module, comprising a bottom-up methodology, and the scene understanding module, comprising a video event representation and recognition scheme, have been demonstrated to be a valid approach for apron monitoring.
MAGNETIC DAMPING FORCES IN THE FIGURE-EIGHT-SHAPED N SYSW (1996)

This paper analyzes the magnetic damping forces resulting from the interaction between the figure-eight-shaped null-flux coil guideway and the damping conductors, including double damping loops, a single damping loop, and a damping plate. The paper uses dynamic circuit theory in combination with a numerical approach to determine the fundamental relationships between the magnetic damping coefficient, which is defined as the ratio of a damping force over the velocity associated with the force and the system parameters. In particular, the damping coefficients associated with the single damping loop and double damping loops, as shown in Figure 2, are obtained in terms of harmonic approximation. Assuming that at a relatively lower oscillation fresuency the resistance in the damping loop is much bigger than its reactance, one can obtain the damping coefficient, Cd, associated with the double-damping-loop system illustrated in Figure 2(a), as where & is the SCM current, Rd is the resistance in the damping coil, Lg is the equivalent inductance of the null-flux coil, and Ms,gu~ and Ms,,lo are the peak mutual inductance between the SCM and the upper and the lower loops of the null-flux coils, respectively. Md,gO is the mutual inductance either between the upper damping loop and the upper null-flux loop or between the lower damping loop and the lower null-flux loop. Similarly, the damping coefficient associated with the single damping loop system illustrated in Figure 2(b), can be exllressed as
Combined Cycles for Pipeline Compressor Drives Using Heat (1979)

Combined cycles for pipeline-booster stations using waste heat from gas turbines exhaust can improve the overall efficiency of such stations remarkably. Several working fluids are suitable. Due to existing criteria for selecting a working medium under mentioned conditions, water, ammonia, propane and butane can be considered as practical working fluids. The investigations have shown that: (a) ammonia is advantageous at low exhaust gas and ambient temperatures, (b) water is most effective at high exhaust gas and ambient temperatures, and (c), additionally, hydrocarbons are suitable in a medium range for exhaust gas and condensing temperatures. Not only thermodynamic but also operational features have to be considered. There is not one optimum working fluid but a best one suitable according to the prevailing site conditions.
Bioengineering Lactic Acid Bacteria to Secrete the HIV-1 Virucide Cyanovirin (2005)

An urgent need exists to prevent the sexual transmission of HIV-1. With prevalence rates exceeding 35% in parts of sub-Saharan Africa, increasing attention has been placed on developing and testing microbicidal agents capable of preventing virus transmission at mucosal sites. HIV-1 microbicides must meet several requirements before their widespread use. The drugs must be able to neutralize a diversity of HIV-1 strains, not induce mucosal inflammation, be associated with minimal side effects, and be effective for a prolonged period after a single application. Recent work has demonstrated the utility of recombinant lactic acid bacteria (LAB) as agents of mucosal drug delivery. Here, we describe the bioengineering of strains of LAB to secrete the prototypic virucidal compound cyanovirin (CV-N) and demonstrate the anti-HIV-1 activity of secreted CV-N. Our results suggest that recombinant LAB may serve as effective microbicidal compounds and deserve in vivo testing in simian immunodeficiency virus models of mucosal virus transmission.
Phytochemical characterization of bioactive compounds composition of Rosmarinus eriocalyx by RP–HPLC–ESI–QTOF–MS (2018)

<i>Rosmarinus eriocalyx</i> (rosemary or Elyazir) is an endemic species growing in arid steppe and rocky mountain in the South-West Algeria. This plant is well known in Algeria and Morocco due to its medicinal properties. However, little is known about its phytochemical composition. For this purpose, natural antioxidant compounds from <i>R. eriocalyx</i> were recovered by solid-liquid extraction and characterized by reversed-phase high-performance liquid chromatography coupled to quadrupole-time-of-flight mass spectrometry using negative and positive ionization modes. This analytical methodology enabled the characterization of 101 compounds, which were distributed in five major categories namely hydroxycinnamic acid derivatives, hydroxybenzoic acid derivatives, flavonoids, phenolic diterpenes and phenolic triterpenes. Moreover, the studied extract generally showed free radical-scavenging and reductive abilities in the range of butylated hydroxyanisole, butylated hydroxytoluene, α-tocopherol<sup>,</sup> and ascorbic acid. Therefore, the result suggests that the aqueous-methanolic extract of <i>R. eriocalyx</i> could serve as a potential source of antioxidants.
PET/CT imaging evidence of FUS‐mediated (18)F‐FDG uptake changes in rat brain (2013)

Spatially distinct increases in the glucose metabolic activity in the rat brain is present only at the center of sonication focus, suggesting localized functional neuromodulation mediated by the sonication.
Nodular elephantoid lymphedema. (1986)

An active, robust, alert 90-year-old man has had nodular elephantoid lymphedema on his left leg for sixty-one years. The patient has been managed conservatively and has not experienced significant morbidity or been hospitalized. The skin healed rapidly when small fibrous nodules were surgically removed.
Alkaloids from the Leaves of Buxus sempervirens (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAlkaloids from the Leaves of Buxus sempervirens Atta-Ur-Rahman, Dildar Ahmed, M. Iqbal Choudhary, Bilge Sener, and Songul TurkozCite this: J. Nat. Prod. 1988, 51, 4, 783–786Publication Date (Print):July 1, 1988Publication History Published online1 July 2004Published inissue 1 July 1988https://pubs.acs.org/doi/10.1021/np50058a024https://doi.org/10.1021/np50058a024research-articleACS PublicationsRequest reuse permissionsArticle Views137Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Capillary Scale Admittance Detection (2014)

Techniques that have been variously termed oscillometric detection or (capacitively coupled) contactless conductivity detection (C(4)D) are known actually to respond to the admittance. It is not often appreciated that the frequency range (f) over which such systems respond (quasi)linearly with the cell conductance decreases acutely with increasing cell resistance. Guidance on optimum operating conditions for high cell resistance, such as for very small capillaries/channels and/or solutions of low specific conductance (σ), is scant. It is specially necessary in this case to take the capacitance of the solution into account. At high frequencies and low σ values, much of the current passes through the solution behaving as a capacitor and the capacitance is not very dependent on the exact solution specific conductance, resulting in poor, zero, or even negative response. We investigated, both theoretically and experimentally, capillaries with inner radii of 5-160 μm and σ ≈ 1-1400 μS/cm, resulting in cell resistances of 51 GΩ to 176 kΩ. A 400-element discrete model was used to simulate the behavior. As model inputs, both the wall capacitance and the stray capacitance were measured. The solution and leakage capacitances were estimated from extant models. The model output was compared to the measured response of the detection system over broad ranges of f and σ. Other parameters studied include capillary material and wall thickness, electrode spacing and length, Faraday shield thickness, excitation wave forms, and amplitude. The simulations show good qualitative agreement with experimental results and correctly predict the negative response behavior observed under certain conditions. We provide optimum frequencies for different operating conditions.
Etude de différents mécanismes d'oxydation de l'ADN par spectroscopie rapide (2003)

L'information genetique peut etre endommagee ou detruite par des facteurs internes ou externes (medicaments, rayonnement UV-visible. . . ), pouvant induire des mutations voire la mort cellulaire. L'oxydation de l'ADN est une des principales lesions: elle peut se produire localement mais aussi a distance par transfert de charge, de proton, d'energie le long de la double helice selon des mecanismes encore mal definis. L'objectif de cette these a ete d'etudier les etapes elementaires (de la femtoseconde a la microseconde) de differents processus d'oxydation de l'ADN. Pour ce faire, diverses molecules interagissant avec les bases nucleiques (camptothecine, MABAP) ou derivees de ces bases (2-chloropyrimidine), toutes a visee therapeutique, ont ete utilisees et etudiees grâce a diverses methodes de spectroscopie d'absorption et de fluorescence. Les resultats ont montre que la formation d'un complexe de stacking entre la camptothecine et les bases guanines etait essentielle a l'activite du medicament et qu'un transfert de charge a partir de l'etat triplet de la camptothecine pour former le radical cation de la guanine expliquait l'activite accrue du medicament sous activation photonique. Le bichromophore bis intercalant de l'ADN (MABAP), capable de s'intercaler entre les paires de bases GC de l'ADN a ete utilise comme nanosonde des transferts de charge et/ou d'energie au sein de l'ADN: un processus d'oxydation local femtoseconde des bases guanines a ete mis en evidence ainsi qu'un dialogue entre les deux chromophores de la MABAP intercalee entre les paires de bases GC, via la mise en evidence d'un transfert d'energie. Des etudes preliminaires, a l'echelle de temps femtoseconde, sur la 2-chloropyrimidine ont permis de poser les bases de l'etude du mecanisme d 'hydroxylation des bases de l'ADN.
Association betweenChlamydia pneumoniaeand Acute Myocardial Infarction in Young Men in the United States Military: The Importance of Timing of Exposure Measurement (2005)

This study demonstrates a significant association between high titers to C. pneumoniae IgG and IgA and acute MI in a cohort of young men and suggests that recent or chronic active infections could be associated with an increased risk for MI.
Loss-of-function mutation in VCP mimics the characteristic pathology as in FTLD-TARDBP (2021)

VCP (valosin containing protein), a member of the AAA+ protein family, is critical for many cellular processes and functions. Dominant VCP mutations cause a rare neurodegenerative disease known as multisystem proteinopathy (MSP). The spectrum of mechanisms causing fronto-temporal dementia with TARDBP/TDP-43 inclusions (FTLD-TARDBP) by VCP disease mutations remains unclear. Our recent work identified VCP activity as a mediator of FTLD-TARDBP. Specifically, brain atrophy, behavioral changes, neuronal loss, gliosis, and TARDBP pathology were observed in <i>vcp</i> conditional knockout (cKO) mice. We also found that autophago-lysosomal dysfunction, TARDBP inclusions, and ubiquitin-proteasome impairment precede neuronal loss. We further studied conditional expression of the disease-associated mutation VCP<sup>R155C</sup> in <i>vcp</i>-null mice. We observed features similar to those of VCP inactivation, suggesting that VCP mutation is hypomorphic. Furthermore, proteomic, and transcriptomic signatures in <i>vcp</i> cKO mice resemble those of GRN/Progranulin carriers. Therefore, VCP is essential for neuronal survival by several mechanisms and could be a therapeutic target aimed at restoring protein homeostasis in patients with FTLD-TARDBP.
Retraction of “Asymmetric Catalysis of the Strecker Amino Acid Synthesis by a Cyclic Dipeptide″ (2023)

ADVERTISEMENT RETURN TO ISSUEPREVRetractionNEXTORIGINAL ARTICLEThis notice is a retraction.Retraction of "Asymmetric Catalysis of the Strecker Amino Acid Synthesis by a Cyclic Dipeptide″Mani S. IyerMani S. IyerMore by Mani S. Iyer, Kenneth M. GigstadKenneth M. GigstadMore by Kenneth M. Gigstad, Nivedita D. NamdevNivedita D. NamdevMore by Nivedita D. Namdev, and Mark Lipton*Mark LiptonMore by Mark LiptonCite this: J. Am. Chem. Soc. 2023, 145, 27, 15016Publication Date (Web):June 29, 2023Publication History Received10 April 2023Published online29 June 2023Published inissue 12 July 2023https://pubs.acs.org/doi/10.1021/jacs.3c03705https://doi.org/10.1021/jacs.3c03705retractionACS PublicationsCopyright © 2023 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views12295Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (771 KB) Get e-Alertsclose Get e-Alerts
Breast cancer risk in a screening cohort of Asian and white British/Irish women from Manchester UK (2018)

Asian women attending screening in Greater Manchester are likely to have a lower risk of breast cancer than white British/Irish women, but they undertake less physical activity and have more adult weight gain.
Uneven Pattern of Dopamine Loss in the Striatum of Patients with Idiopathic Parkinson's Disease (1988)

Autografting of dopamine-producing adrenal medullary tissue to the striatal region of the brain is now being attempted in patients with Parkinson's disease. Since the success of this neurosurgical approach to dopamine-replacement therapy may depend on the selection of the most appropriate subregion of the striatum for implantation, we examined the pattern and degree of dopamine loss in striatum obtained at autopsy from eight patients with idiopathic Parkinson's disease. We found that in the putamen there was a nearly complete depletion of dopamine in all subdivisions, with the greatest reduction in the caudal portions (less than 1 percent of the dopamine remaining). In the caudate nucleus, the only subdivision with severe dopamine reduction was the most dorsal rostral part (4 percent of the dopamine remaining); the other subdivisions still had substantial levels of dopamine (up to approximately 40 percent of control levels). We propose that the motor deficits that are a constant and characteristic feature of idiopathic Parkinson's disease are for the most part a consequence of dopamine loss in the putamen, and that the dopamine-related caudate deficits (in "higher" cognitive functions) are, if present, less marked or restricted to discrete functions only. We conclude that the putamen--particularly its caudal portions--may be the most appropriate site for intrastriatal application of dopamine-producing autografts in patients with idiopathic Parkinson's disease.
Electro-optic imagery of high-voltage GaAs photoconductive switches (1995)

We present electro-optic images of GaAs high-voltage photoconductive switches utilizing the electro-optic effect of the semi-insulating GaAs substrate. Experimental methodology for obtaining the images is described along with a self-calibrating data reduction algorithm. Use of the technique for observing fabrication defects is shown.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Optimization of Nonlinear Signal Constellations for Real-World MIMO Channels (2004)

The performance of spatial multiplexing (SM) multiple-input multiple-output (MIMO) communication systems is highly dependent on the richness of scattering, the presence of dominant components, and the interelement spacings. In this paper, a new interpretation of the impact of transmit correlation on the performance of SM is given based on a so-called "symbol-related array factor." Nonlinear signal constellations for SM over real-world fading channels are then designed by minimizing an estimate of the average symbol error rate under an average transmit power constraint. The new transmission scheme exploits the spectral efficiency advantage of SM and the robustness of eigen-beamforming. Through simulations, it is shown to be more robust against fading correlations and high Ricean K-factors than SM using the classical phase shift keying (PSK) and quadrature amplitude modulation (QAM) constellations. The symbol error rate performance of this scheme is not affected by a change in the propagation environment or the interelement distance. Furthermore, if the scheme is used on the uplink, no explicit rate-consuming feedback link from the base station to the mobile station is required.