gebhart/patrepeval huggingface dataset:
Effect of the Extent of Surgical Resection on Survival and Quality of Life in Patients with Supratentorial Glioblastomas and Anaplastic Astrocytomas (1987)

Thirty-one patients operated upon for supratentorial glioblastomas or anaplastic astrocytomas were studied to evaluate the effect of the extent of surgical resection on the length and quality of survival. The median age was 50 years and the median preoperative Karnofsky rate was 80. Twenty-one patients (68%) had glioblastoma multiforme, and 10 patients (32%) had anaplastic astrocytoma. Early postoperative enhanced computed tomography was used to determine the extent of tumor resection. Gross total tumor resection was accomplished in 19 patients (61%), and subtotal resection was performed in 12 patients (39%). The two groups were comparable regarding age, sex, pathological condition, preoperative Karnofsky rating, tumor location, postoperative radiation therapy, and postoperative chemotherapy (P greater than 0.05). The gross total resection group lived longer than the subtotal resection group by life table analysis (P less than 0.001; median survival of 90 and 43 weeks, respectively). Postoperatively, the mean functional ability measured by the Karnofsky rating was significantly increased in the gross total resection group (P = 0.006), but not in the subtotal resection group (P greater than 0.05). The difference in degree of change between preoperative and postoperative Karnofsky rating in the two groups was statistically significant (P = 0.002). The gross total resection group spent significantly more time after the operation in an independent status (Karnofsky rating greater than or equal to 80) compared to the subtotal resection group (P = 0.007; median time of 185 and 12.5 weeks, respectively). Gross total resection of supratentorial glioblastomas and anaplastic astrocytomas is feasible and is directly associated with longer and better survival when compared to subtotal resection.
ChemInform Abstract: Three Novel Diarylheptanoids, Calyxin A, Calyxin B, and 3‐Epicalyxin B from a Chinese Crude Drug “Yunnan Cao Kou” (Alpinia blepharocalyx K. Schum.). (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Digital imaging colposcopy: basic concepts and applications. (1993)

The technique of colposcopy has changed little since the introduction of the green filter to improve viewing of vascular structures. However, the recent dramatic improvements in computer technology now make it practical to combine computerized image processing with colposcopy, which we have termed "digital imaging colposcopy." Image processing techniques permit contrast enhancement of features, such as white epithelium and abnormal vasculature. The digital colposcope allows rapid measurement of the cervical area involved with visible lesions, providing an improved means of following the progression of these lesions over time.
An improved method of competitive PCR for quantitation of gene copy number (1993)

Journal Article An improved method of competitive PCR for quantitation of gene copy number Get access Guoren Deng, Guoren Deng Geraldine Brush Cancer Research Institute, California Pacific Medical CenterSan Francisco,CA94115, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Mei Yu, Mei Yu Geraldine Brush Cancer Research Institute, California Pacific Medical CenterSan Francisco,CA94115, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Helene S. Smith Helene S. Smith Geraldine Brush Cancer Research Institute, California Pacific Medical CenterSan Francisco,CA94115, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 21, Issue 20, 11 October 1993, Pages 4848–4849, https://doi.org/10.1093/nar/21.20.4848 Published: 11 October 1993 Article history Received: 24 August 1993 Accepted: 06 September 1993 Published: 11 October 1993
Spinal cord protein interacting with C kinase 1 is required for the maintenance of complete Freund's adjuvant-induced inflammatory pain but not for incision-induced post-operative pain (2010)

Protein interacting with C kinase 1 (PICK1) is a PDZ-containing protein that binds to AMPA receptor (AMPAR) GluR2 subunit and protein kinase Cα (PKCα) in the central neurons. It functions as a targeting and transport protein, presents the activated form of PKCα to synaptic GluR2, and participates in synaptic AMPAR trafficking in the nervous system. Thus, PICK1 might be involved in many physiological and pathological processes triggered via the activation of AMPARs. We report herein that PICK1 knockout mice display impaired mechanical and thermal pain hypersensitivities during complete Freund's adjuvant (CFA)-induced inflammatory pain maintenance. Acute transient knockdown of spinal cord PICK1 through intrathecal injection of PICK1 antisense oligodeoxynucleotide had a similar effect. In contrast, knockout and knockdown of spinal cord PICK1 did not affect incision-induced guarding pain behaviors or mechanical or thermal pain hypersensitivities. We also found that PICK1 is highly expressed in dorsal horn, where it interacts with GluR2 and PKCα. Injection of CFA into a hind paw, but not a hind paw incision, increased PKCα-mediated GluR2 phosphorylation at Ser880 and GluR2 internalization in dorsal horn. These increases were absent when spinal cord PICK1 was deficient. Given that dorsal horn PKCα-mediated GluR2 phosphorylation at Ser880 and GluR2 internalization contribute to the maintenance of CFA-induced inflammatory pain, our findings suggest that spinal PICK1 may participate in the maintenance of persistent inflammatory pain, but not in incision-induced post-operative pain, through promoting PKCα-mediated GluR2 phosphorylation and internalization in dorsal horn neurons.
Complementarity and the uncertainty relations (1999)

We formulate a general complementarity relation starting from any Hermitian operator with discrete nondegenerate eigenvalues. We then elucidate the relationship between quantum complementarity and the Heisenberg-Robertson uncertainty relation. We show that they are intimately connected. Finally we exemplify the general theory with some specific suggested experiments.
A comparative morphometric analysis of the optic nerve in two cetacean species, the striped dolphin (Stenella coeruleoalba) and fin whale (Balaenoptera physalus) (2001)

A comparative study was made on one Mysticete (the fin whale, Balaenoptera physalus) and one Odontocete species (the striped dolphin, Stenella coeruleoalba) by measuring several morphological characteristics seen in cross sections of the optic nerve. We found that the two cetacean nerves share a number of specializations that distinguish them from the optic nerve of terrestrial mammals. Fiber density is approximately two-fold lower than in land mammals. A corresponding increase in the cross-sectional area occupied by astrocytes is observed. A population of "giant" (up to 15 microm in diameter) optic axons is present in both the B. physalus and the S. coeruleoalba nerve. It is argued that these features probably reflect common adaptations to the constraints imposed by the aquatic environment. "Giant" optic axons might ensure short-latency detection of preys and other targets during navigation while the increased astroglial content might be related to the maintenance of neuronal function during periods of anaerobic metabolism under water.
A direct-conversion RF scanning receiver based on photonics (2016)

A photonics-based direct-conversion RF receiver has been realized and characterized. The innovative architecture uses coherent optical techniques to perform a fast and wideband scan of the RF spectrum avoiding bulky multiple crystal oscillators. The direct-conversion approach based on photonics enables filtering the input signal spectrum by means of a simple electrical low pass filter, and provide total immunity to local oscillator self-mixing and to RF-to-baseband feedthrough, which are typical drawbacks of conventional direct-conversion receivers. The experimental validation shows an operating bandwidth of 0.5÷10.5 GHz and instantaneous bandwidth of 1 GHz, with linear dynamic range of 141 dB/Hz and spurious-free dynamic range of 107 dB/Hz⅔. Further system developments will enhance the operating bandwidth up to 40 GHz. Implementing the scheme through integrated photonics technologies will also ensure high environmental stability and reduced size weight and power consumption.
A machine-vision approach for automated pain measurement at millisecond timescales (2020)

Objective and automatic measurement of pain in mice remains a barrier for discovery in both basic and translational neuroscience. Here we capture rapid paw kinematics during pain behavior in mice with high-speed videography and automated paw tracking with machine and deep learning approaches. Our statistical software platform, PAWS (Pain Assessment at Withdrawal Speeds), uses a univariate projection of paw position over time to automatically quantify fast paw dynamics at the onset of paw withdrawal and also lingering pain-related behaviors such as paw guarding and shaking. Applied to innocuous and noxious stimuli across six inbred mouse strains, a linear discriminant analysis reveals a two-dimensional subspace that separates painful from non-painful stimuli on one axis, and further distinguishes the severity of pain on the second axis. Automated paw tracking combined with PAWS reveals behaviorally-divergent mouse strains that display hypo- and hyper-sensitivity to mechanical stimuli. To demonstrate the efficacy of PAWS for detecting hypersensitivity to noxious stimuli, we chemogenetically activated pain-aversion neurons in the amygdala, which further separated the behavioral representation of pain-related behaviors along a low-dimensional path. Taken together, this automated pain quantification approach should increase the ease and objectivity of collecting rigorous behavioral data, and it is compatible with other neural circuit dissection tools for determining the mouse pain state.
Comment on “CO2 Utilization Feasibility Study: Dimethyl Carbonate Direct Synthesis Process with Dehydration Reactive Distillation” (2020)

ADVERTISEMENT RETURN TO ISSUEPREVCorrespondenceNEXTComment on “CO2 Utilization Feasibility Study: Dimethyl Carbonate Direct Synthesis Process with Dehydration Reactive Distillation”Daniel C. RedekerDaniel C. RedekerDepartment of Chemical Engineering, University of California−Davis, Davis, California 95616, United StatesMore by Daniel C. Redeker, Daniel Y. JiangDaniel Y. JiangDepartment of Chemical Engineering, University of California−Davis, Davis, California 95616, United StatesMore by Daniel Y. Jiang, Jesse S. KullarJesse S. KullarDepartment of Chemical Engineering, University of California−Davis, Davis, California 95616, United StatesMore by Jesse S. Kullar, Vincent LeungVincent LeungDepartment of Chemical Engineering, University of California−Davis, Davis, California 95616, United StatesMore by Vincent Leung, Ahmet PalazogluAhmet PalazogluDepartment of Chemical Engineering, University of California−Davis, Davis, California 95616, United StatesMore by Ahmet Palazogluhttp://orcid.org/0000-0002-4455-8749, and Matthew J. Ellis*Matthew J. EllisDepartment of Chemical Engineering, University of California−Davis, Davis, California 95616, United States*E-mail: [email protected]More by Matthew J. EllisCite this: Ind. Eng. Chem. Res. 2020, 59, 34, 15387–15389Publication Date (Web):August 12, 2020Publication History Published online12 August 2020Published inissue 26 August 2020https://doi.org/10.1021/acs.iecr.0c03372Copyright © 2020 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views722Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (626 KB) Get e-AlertsSUBJECTS:Hydrocarbons,Equilibrium constant,Alcohols,Equilibrium,Theoretical and computational chemistry Get e-Alerts
Aqueous Microgels Modified by Wedge-Shaped Amphiphilic Molecules: Hydrophilic Microcontainers with Hydrophobic Nanodomains (2009)

A simple route for the design of hydrophilic microgels comprising inner hydrophobic nanodomains has been developed based on postmodification of microgels by complexation of wedge-shaped amphiphilic molecules with complementary functional groups. Aqueous microgels functionalized with imidazole groups were transferred into an organic medium, where imidazole groups were neutralized by water-insoluble wedge-shaped molecules bearing a sulfonic acid group at the tip of the wedge and a large hydrocarbon body. After redispersion of the modified microgel particles into the aqueous phase, wedge-shaped amphiphiles ionically attached to the polymer chains self-assembled into discrete nanodomains in the interior of the polymer colloids due to the hydrophobic attraction force. The loading of the wedge-shaped molecules into microgels can be controlled by variation of the amount of imidazole groups integrated into the microgel network as well as the neutralization degree. The experimental results suggested that incorporation of hydrophobic domains into hydrophilic colloids induced dramatic changes of their properties such as swelling degree, surface charge, and responsiveness toward temperature and pH. Finally, we demonstrated that internally hydrophobized microgel particles are very effective in uptake of hydrophobic molecules in aqueous media.
Potential for a biopesticide bait to control black beetle, Heteronychus arator (Coleoptera: Scarabaeidae) (2020)

Heteronychus arator is a difficult pest to manage using chemical insecticides. This biopesticide with Y. entomophaga as the active ingredient offers a new solution for New Zealand pastures, with potential for application to other crops affected by H. arator and for control of other pests. © 2020 Society of Chemical Industry.
Application of a Genetic Algorithm to Wind Turbine Design (1996)

This paper presents an optimization method for stall-regulated horizontal-axis wind turbines. A hybrid approach is used that combines the advantages of a genetic algorithm with an inverse design method. This method is used to determine the optimum blade pitch and blade chord and twist distributions that maximize the annual energy production. To illustrate the method, a family of 25 wind turbines was designed to examine the sensitivity of annual energy production to changes in the rotor blade length and peak rotor power. Trends are revealed that should aid in the design of new rotors for existing turbines. In the second application, five wind turbines were designed to determine the benefits of specifically tailoring wind turbine blades for the average wind speed at a particular site. The results have important practical implications related to rotors designed for the Midwestern US versus those where the average wind speed may be greater.
3D dental mesh repairing using template-based deformation (2014)

This paper proposes a mesh repairing method for segmented intra-oral scanned dental meshes. The method uses templates to provide additional dental information to repair missing parts on incomplete segmented dental meshes. The missing parts are determined by registration result using improved Iterative Closest Point (ICP) method, followed by a deformation-based repairing process. Using information from well-established templates, the repairing can provide reliable estimation for large missing area. The proposed method is automatic, simple, efficient and effective regarding different tooth shapes and missing parts. The conducted experiments demonstrate the effectiveness of the method.
Data from Specifically Targeting Angiopoietin-2 Inhibits Angiogenesis, Tie2-Expressing Monocyte Infiltration, and Tumor Growth (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Angiopoietin-1 (Ang1) plays a key role in maintaining stable vasculature, whereas in a tumor Ang2 antagonizes Ang1's function and promotes the initiation of the angiogenic switch. Specifically targeting Ang2 is a promising anticancer strategy. Here we describe the development and characterization of a new class of biotherapeutics referred to as CovX-Bodies, which are created by chemical fusion of a peptide and a carrier antibody scaffold.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Various linker tethering sites on peptides were examined for their effect on CovX-Body &lt;i&gt;in vitro&lt;/i&gt; potency and pharmacokinetics. Ang2 CovX-Bodies with low nmol/L IC&lt;sub&gt;50&lt;/sub&gt;s and significantly improved pharmacokinetics were tested in tumor xenograft studies alone or in combination with standard of care agents. Tumor samples were analyzed for target engagement, via Ang2 protein level, CD31-positive tumor vasculature, and Tie2 expressing monocyte penetration.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Bivalent Ang2 CovX-Bodies selectively block the Ang2–Tie2 interaction (IC&lt;sub&gt;50&lt;/sub&gt; &lt; 1 nmol/L) with dramatically improved pharmacokinetics (&lt;i&gt;T&lt;/i&gt;&lt;sub&gt;½&lt;/sub&gt; &gt; 100 hours). Using a staged Colo-205 xenograft model, significant tumor growth inhibition (TGI) was observed (40%–63%, &lt;i&gt;P&lt;/i&gt; &lt; 0.01). Ang2 protein levels were reduced by approximately 50% inside tumors (&lt;i&gt;P&lt;/i&gt; &lt; 0.01), whereas tumor microvessel density (&lt;i&gt;P&lt;/i&gt; &lt; 0.01) and intratumor proangiogenic Tie2&lt;sup&gt;+&lt;/sup&gt;CD11b&lt;sup&gt;+&lt;/sup&gt; cells (&lt;i&gt;P&lt;/i&gt; &lt; 0.05) were significantly reduced. When combined with sunitinib, sorafenib, bevacizumab, irinotecan, or docetaxel, Ang2 CovX-Bodies produced even greater efficacy (∼80% TGI, &lt;i&gt;P&lt;/i&gt; &lt; 0.01).&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusion:&lt;/b&gt; CovX-Bodies provide an elegant solution to overcome the pharmacokinetic–pharmacodynamic problems of peptides. Long-acting Ang2 specific CovX-Bodies will be useful as single agents and in combination with standard-of-care agents. &lt;i&gt;Clin Cancer Res; 17(5); 1001–11. ©2011 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Prevention of Type 1 Diabetes (2003)

Abstract Increasing knowledge of the cellular and molecular mechanisms of autoimmune pancreatic β‐cell destruction, together with proof‐of‐principle for therapeutic interventions in the nonobese diabetic mouse model, provides a platform for the prevention of type 1 diabetes in humans. The concept of prevention extends to people with clinical diabetes, not only to preserve residual β‐cell function but to prevent recurrent autoimmune disease after therapeutic β‐cell replacement or regeneration. Primary prevention awaits the identification of environmental agents that trigger or promote disease on a background of genetic susceptibility. The last two decades have, however, witnessed clinical trials of a range of candidate agents for secondary prevention, predominantly in people with recently diagnosed diabetes. It can be argued that intervention is likely to be more effective in those at risk, identified by the presence of circulating islet antibodies. Strategies for secondary prevention encompass nonspecific immune suppression, nonspecific immune stimulation, nonspecific immune regulation, antigen‐specific immune regulation, and β‐cell protection. The shift has been away from nonspecific immunosuppressive drugs to more specific immunoregulatory agents. Preservation of C‐peptide secretion in the first year after diagnosis has been demonstrated in some randomized trials, but has not been sustained. Autoantigen‐induced immune regulation, which is safe and effective in animal models of autoimmune disease, requires further evaluation in at‐risk humans. The need for better surrogate immune and metabolic response markers, especially islet antigen‐reactive T‐cells, remains pressing. The prevention of type 1 diabetes will most likely occur incrementally, with increasingly specific and targeted agents being evaluated according to disease stage and risk, analogous to the evolving treatment regimens for cancer or HIV. This chapter describes the rationale and current approaches to the prevention of type 1 diabetes.
Low temperature poly-Si thin-film transistor fabrication by metal-induced lateral crystallization (1996)

A new low temperature crystallization method for poly-Si TFTs was developed: Metal-Induced Lateral Crystallization (MILC). The a-Si film in the channel area of a TFT was laterally crystallized from the source/drain area, on which an ultrathin nickel layer was deposited before annealing. The a-channel poly-Si TFTs fabricated at 500/spl deg/C by MILC showed a mobility of 121 cm/sup 2//V/spl middot/s, a threshold voltage of 1.2 V, and an on/off current ratio of higher than 10/sup 6/. These electrical properties are much better than TFTs fabricated by conventional crystallization at 600/spl deg/C.
Infrared and Raman studies of some monounsaturated olefinic and acetylenic fatty acids and their derivatives (1972)

The Raman spectra (800–3200 cm–1) of carbon tetrachloride solutions of the 15 isomeric methyl cis-octadecenoates, the 15 isomeric trans-octadecenoic acids, methyl octadec-17-enoate, and of the 16 isomeric octadecynoic acids have been obtained. Provided that the double bond is not conjugated with the carbonyl group, and does not occur in the terminal position, the double-bond vibration gives rise to a strong Raman band at 1656 ± 1 cm–1 for the cis-compounds, and to a strong band at 1670 ± 1 cm–1 for the trans-compounds. Conjugation with the carbonyl group lowers the value by 8 cm–1, and for the terminal double bond the value is 1642 cm–1. The triple-bond vibration gives rise to two Raman bands at 2232 ± 1 cm–1(s) and 2291 ± 2 cm–1(m). When the triple bond is conjugated with the carbonyl group only one band at 2245 cm–1 is observed. The terminal triple bond gives a single band at 2120 cm–1. From a comparison of the i.r. and Raman spectra of the methyl cis- and trans-octadec-8-enoates an assignment is suggested for the vibrational modes of the cis- and trans-CHCH– units.
Submicrometer Ferromagnetic NOT Gate and Shift Register (2002)

An all-metallic submicrometer device is demonstrated experimentally at room temperature that performs logical NOT operations on magnetic logic signals. When this two-terminal ferromagnetic structure is incorporated into a magnetic feedback loop, the junction performs a frequency division operation on an applied oscillating magnetic field. Up to 11 of these junctions are then directly linked together to create a magnetic shift register.