gebhart/patrepeval huggingface dataset:
Expression of the Costimulatory Molecule B7-H2 (Inducible Costimulator Ligand) by Human Airway Epithelial Cells (2003)

Tissue structural cells are known in some situations to play a role in the presentation of antigen and in immunoregulation. We assessed the expression of B7 homologs, known to be involved in antigen presentation and lymphocyte costimulation, in human airway epithelial cells. Flow cytometry performed on the airway epithelial cell line BEAS-2B, as well as primary bronchial epithelial cells (PBEC), showed that B7-H2 was constitutively expressed on both BEAS-2B and PBEC, whereas B7-1 and B7-2 were undetectable on either epithelial cell type. B7-H2 expression was confirmed by Western blot using a specific antibody. Stimulation with various cytokines, including tumor necrosis factor-alpha, interferon-gamma, and interleukin-4, slightly downregulated B7-H2 expression detected by flow cytometry, but did not significantly alter the apparent level of protein as assessed by Western blotting. Northern blotting detected mRNA for B7-H2 and B7-1, but not B7-2. B7-H2 was cloned from BEAS-2B cells and the sequence verified. Expression of B7-H2 mRNA was detected by real-time reverse transcriptase-polymerase chain reaction in PBEC from three independent donors. Immunohistochemical analysis of airway derived from autopsies revealed expression of B7-H2 in human airway epithelial cells. These results demonstrate that airway epithelial cells express the costimulatory molecule B7-H2, and suggest the possibility that B7-H2 may participate in antigen presentation by epithelial cells.
Anisotropic syntheses of boat-shaped core–shell Au–Ag nanocrystals and nanowires (2006)

This paper describes the syntheses of boat-shaped core–shell Au–Ag bimetallic nanoparticles (NPs) and Au–Ag bimetallic nanowires (NWs). Initially, gold nanorods (AuNRs) having lengths and widths of 70 ± 18 and 12 ± 2 nm, respectively, were prepared from gold seeds in the presence of hexadecyltrimethylammonium bromide (CTAB), benzyldimethylammonium chloride (BDAC), NaAuCl4, AgNO3, and ascorbic acid. The thus-prepared AuNRs were then used to prepare boat-shaped core–shell Au–Ag bimetallic NPs in a glycine solution (pH 8.0) containing CTAB, AgNO3, and ascorbic acid. The CTAB/BDAC molar ratio and the AgNO3 concentration were important parameters affecting the anisotropy of the products. Silver atoms were deposited at both ends of the AuNRs to form the boat-shaped core–shell Au–Ag bimetallic NPs. Upon coalescence of the NPs at 88 ± 2 °C, the boat-shaped core–shell Au–Ag bimetallic NPs assembled into the form of NWs. These NWs, which were stable in solution at room temperature for at least 3 weeks, formed nanomaterials containing AuNRs after being heated at 210 °C for 15 min, i.e. as a result of the melting of the BDAC and silver shells.
Abstract 16494: Rapamycin Enhances Protective Effect of Sildenafil against Doxorubicin Cardiotoxicity and Potentiates Cancer Cell Killing (2012)

Background: Doxorubicin (DOX) is one of the most widely used chemotherapeutics for the treatment of various cancers. However, its use has been limited due to severe cardiotoxicity. Sildenafil (Sild...
CUDA-MPI-FDTD implementation of Maxwell's equations in general dispersive media (2012)

In this research, we present the first MPI-CUDA implementation of Finite-Difference Time-Domain (FDTD) discretization of Maxwell's equations in dispersive media that uses the MPI API to assign each CPU node its share of the computational domain and GPUs to their corresponding CPU threads. By taking advantage of the CUDA programming model, we present a unique implementation of the FDTD scheme that exploits the memory hierarchy of GPUs, including the global, texture, and shared memory. This enables us to tackle problems that are otherwise computationally prohibitive. Practical results will be presented along with a measure of speedup factors achieved when using multiple GPU processors.
Increased Blood Pressure After Abrupt Cessation of Daily Cannabis Use (2010)

Abrupt cessation of heavy cannabis use may cause clinically significant increases in BP in a subset of users. BP should be monitored among those attempting to reduce or quit frequent cannabis use, particularly those with preexisting hypertension. The time course of this effect is currently unknown and requires further study.
Large-Scale Synthesis of Bioinert Tantalum Oxide Nanoparticles for X-ray Computed Tomography Imaging and Bimodal Image-Guided Sentinel Lymph Node Mapping (2011)

Ever since Au nanoparticles were developed as X-ray contrast agents, researchers have actively sought alternative nanoparticle-based imaging probes that are not only inexpensive but also safe for clinical use. Herein, we demonstrate that bioinert tantalum oxide nanoparticles are suitable nanoprobes for high-performance X-ray computed tomography (CT) imaging while simultaneously being cost-effective and meeting the criteria as a biomedical platform. Uniformly sized tantalum oxide nanoparticles were prepared using a microemulsion method, and their surfaces were readily modified using various silane derivatives through simple in situ sol-gel reaction. The silane-modified surface enabled facile immobilization of functional moieties such as polyethylene glycol (PEG) and fluorescent dye. PEG was introduced to endow the nanoparticles with biocompatibility and antifouling activity, whereas immobilized fluorescent dye molecules enabled simultaneous fluorescence imaging as well as X-ray CT imaging. The resulting nanoparticles exhibited remarkable performances in the in vivo X-ray CT angiography and bimodal image-guided lymph node mapping. We also performed an extensive study on in vivo toxicity of tantalum oxide nanoparticles, revealing that the nanoparticles did not affect normal functioning of organs.
Cross-Platform Radar Resource Management for Coordinated Search and Tracking (2021)

This article considers the problem of coordinating the search-and-tracking efforts of multiple airborne-phased array radars. Our goal is to control multiple platforms' AESA radars such that the joint search task along with the resulting tracking tasks are executed cooperatively by several platforms in a way that optimizes the use of available multi-platform radar resources. The benefits arising from such cooperation are demonstrated using simulated examples. This is a first step toward holistic multisensor–multiplatform management, envisaged to be necessary in dense scenarios, as platforms would get saturated when executing all tasks individually on their own. If, on the other hand, the platforms share the tasks to be executed, then all tasks might be executed, potentially also more satisfactorily with respect to achieved performance and quality.
Coded excitation for infrared non-destructive testing of carbon fiber reinforced plastics (2011)

This paper proposes a Barker coded excitation for defect detection using infrared non-destructive testing. Capability of the proposed excitation scheme is highlighted with recently introduced correlation based post processing approach and compared with the existing phase based analysis by taking the signal to noise ratio into consideration. Applicability of the proposed scheme has been experimentally validated on a carbon fiber reinforced plastic specimen containing flat bottom holes located at different depths.
A Radioimmunoassay for Murine Thyroglobulin in Serum: Age-Related Increase of Serum Thyroglobulin Levels in AKR/J Mice* (1983)

Possible regulation of the synthesis of murine thyroglobulin (mTg) and a possible role for the major histocompatibility complex in this process were evaluated in 18 inbred strains of mice. A double antibody RIA was first developed to measure mTg in serum. The isolated mTG was labeled with 131I since 125I rapidly degraded the mTg molecule. The sensitivity of this mTg assay allowed detection of 15-20 ng/ml. Specificity was demonstrated by the minimal cross-reactivity with rat Tg (0.008%) and the total lack of cross-reactivity with human Tg. There was no correlation between H-2 haplotype and serum mTg levels. In five strains of mice with the H-2k haplotype, mTg levels varied from 30 +/- 2 to 48 +/- 11 ng/ml (mean +/- SD); however, only aged AKR/J mice (H-2k) exceeded this range (196 +/- 27 ng/ml). Strains with other haplotypes (a, b, d, g, q, v) demonstrated a similar range of mTg levels, but none had this age-related increase in mTg levels. The high levels of mTg were not caused by a decrease in the half-life of this protein and probably not caused by virus-induced alterations in the thyroid economy. Thyroids from the AKR/J mice, however, had larger follicles and flatter epithelia compared to thyroids from other strains. These studies suggest that AKR/J mice may represent a useful animal model for the study of goitrogenesis.
Closure and convergence: a formulation of fault-tolerant computing (2003)

The authors give a formal definition of what it means for a system to tolerate a class of faults. The definition consists of two conditions. First, if a fault occurs when the system state is within some larger set and, if faults continue occurring, the system state remains within that larger set. Second, if faults stop occurring, the system eventually reaches a state within the legal set. The authors demonstrate the applicability of the definition for stating and verifying the fault-tolerance properties of a variety of digital and computer systems. Using the definition, a simple classification is obtained of fault-tolerant systems, and methods for the systematic design of fault-tolerant systems are outlined.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
330. Hafnium alkoxides (1953)

D. C. Bradley, R. C. Mehrotra and W. Wardlaw, J. Chem. Soc., 1953, 1634 DOI: 10.1039/JR9530001634
Palladium Coordination Compounds of σ3λ5-Phosphoranes:  First Examples of Phosphonio−Methylene(imino)metallophosphorane [(R3P)(Me3Si)CP(MLn)NSiMe3] and Phosphonio−Methylene(oxo)phosphorane [(R3P)(Me3Si)CP(O)NSiMe3] Ligands (1998)

The oxidative addition reaction of Pd(PPh3)4 with Cl2CPN(SiMe3)2 forms the phosphavinyl phosphonium complex Cl(Ph3P)Pd[η2-C(Cl)(PPh3)PN(SiMe3)2] (IIIa), which results from PPh3 migration from Pd to carbon in the η1-phosphavinyl intermediate trans-Cl(Ph3P)2Pd[C(Cl)PN(SiMe3)2] (IIa). The reaction of Pd(dba)(dppe) with Cl2CPN(SiMe3)2 forms the η1-phosphavinyl complex cis-Cl(dppe)Pd[C(Cl)PN(SiMe3)2] (VI), which does not undergo phosphine migration. Compound IIIa undergoes substitution of the chloride ligand by PPh3 or MeCN in the presence of KPF6 to generate [(Ph3P)2Pd(η2-C(Cl)(PPh3)PN(SiMe3)2)](PF6) (IV) or [(Ph3P)(MeCN)Pd(η2-C(Cl)(PPh3)PN(SiMe3)2)](PF6) (V), respectively; the structure of V was determined by X-ray diffraction studies. The reaction of Pd(PEt3)4 with Cl2CPN(SiMe3)2 forms the η1-phosphavinyl complex trans-Cl(Et3P)2Pd[C(Cl)PN(SiMe3)2] (IIb), which does not undergo PEt3 migration. When 2 equiv of Pd(PEt3)4 are reacted with Cl2CPN(SiMe3)2 the phosphonio−methylene(imino)metallophosphorane complex Pd(PEt3)(Cl)[μ-η1:η2-C(SiMe3)(PEt3)PN(SiMe3)]Pd(PEt3)Cl (VIIa-b) forms as a 1:1 isomeric mixture. Compound VIIa-b reacts with MeI or NaI to generate Pd(PEt3)(I)[μ-η1:η2-C(SiMe3)(PEt3)PN(SiMe3)]Pd(PEt3)I (VIIIa-b) and reacts with traces of water to generate Cl(Et3P)Pd[η2-C(SiMe3)(PEt3)P(O)NH(SiMe3)] (IX). The structure of VIIIb was partially determined, and the structure of IX was determined by X-ray diffraction studies. Compounds VIIa-b, VIIIa-b, and IX exhibit the first examples of coordinated methylene(imino, oxo)phosphorane ligands.
Scene Representation Technologies for 3DTV—A Survey (2007)

3-D scene representation is utilized during scene extraction, modeling, transmission and display stages of a 3DTV framework. To this end, different representation technologies are proposed to fulfill the requirements of 3DTV paradigm. Dense point-based methods are appropriate for free-view 3DTV applications, since they can generate novel views easily. As surface representations, polygonal meshes are quite popular due to their generality and current hardware support. Unfortunately, there is no inherent smoothness in their description and the resulting renderings may contain unrealistic artifacts. NURBS surfaces have embedded smoothness and efficient tools for editing and animation, but they are more suitable for synthetic content. Smooth subdivision surfaces, which offer a good compromise between polygonal meshes and NURBS surfaces, require sophisticated geometry modeling tools and are usually difficult to obtain. One recent trend in surface representation is point-based modeling which can meet most of the requirements of 3DTV, however the relevant state-of-the-art is not yet mature enough. On the other hand, volumetric representations encapsulate neighborhood information that is useful for the reconstruction of surfaces with their parallel implementations for multiview stereo algorithms. Apart from the representation of 3-D structure by different primitives, texturing of scenes is also essential for a realistic scene rendering. Image-based rendering techniques directly render novel views of a scene from the acquired images, since they do not require any explicit geometry or texture representation. 3-D human face and body modeling facilitate the realistic animation and rendering of human figures that is quite crucial for 3DTV that might demand real-time animation of human bodies. Physically based modeling and animation techniques produce impressive results, thus have potential for use in a 3DTV framework for modeling and animating dynamic scenes. As a concluding remark, it can be argued that 3-D scene and texture representation techniques are mature enough to serve and fulfill the requirements of 3-D extraction, transmission and display sides in a 3DTV scenario.
Heart Rate Dynamics after Combined Endurance and Strength Training in Older Men (2009)

Fractal HR dynamics were improved more by combining strength training with endurance training in our older men compared with endurance training alone, although strength training alone produced no changes in fractal HR behavior. The synergistic effect in fractal HR behavior occurred regardless of changes in aerobic capacity.
Construction, interfacing, and application of an 8255-based programmable peripheral interface card (2002)

This project describes the construction and application of an 8255-based network interface card (NIC). With the integration of an interface card, software routines, and electronics components, a powerful interfacing and data communication tool can be developed. The 8255 based interface card is a digital input/output device used to interface a personal computer with devices external to the computer. The interface card extends a personal computer's capabilities. The interface card allows control and monitoring functions through software developed by the user.
A CRITICAL REVIEW OF THE FLOODING LITERATURE (1986)

This paper presents an extensive review of the process of flooding and its associated phenomena in countercurrent pipe flow. Analytical models developed previously for condensing two-phase flow as well as for adiabatic two-phase flow are reviewed and compared with experimental data. A classification of these models is suggested in terms of stability theory of a travelling wave, envelope theory, static equilibrium theory and slug formation theory. The ranges of validity of the models are examined and discussed for various flow conditions. The available evidence on the parametric dependence of the flooding curve is also discussed.
Dual‐optimisation of power sources including plug‐in electric vehicles and renewable energy resources at transmission‐level system (2019)

With the growing trend of plug‐in electric vehicles (PEVs), the charging load of PEVs can have a huge impact on current transmission‐level system. In the meantime, there also comes a great potential in the optimisation aspect for both power generation economic and power transmission safety concerns. Here, a dual‐optimisation algorithm is developed to minimise the total production cost of power sources including renewable energy resources (RER) and PEV cluster. In the meantime, the overloading in transmission lines and transformers is avoided. Linear programming and DC optimal power flow (DCOPF) are separately applied to step one and step two optimisation. The simulation result from a modified IEEE 9‐bus system reveals that dual‐optimisation method successfully reduced the production cost based on a hybrid model of power grid in step one optimisation. In step two optimisation, the overloaded transmission line is detected and held at capacity limit to prevent overheating. In conclusion, in dual‐optimisation algorithm, PEVs can serve as both the energy storage device and the energy supply device. Consequently, the total production cost can be reduced, and the optimal power flow can be obtained.
Direct manipulation vs. interface agents (1997)

article Free Access Share on Direct manipulation vs. interface agents Authors: Ben Shneiderman Univ. of Maryland, College Park Univ. of Maryland, College ParkView Profile , Pattie Maes Massachusetts Institute of Technology, Cambridge Massachusetts Institute of Technology, CambridgeView Profile Authors Info & Claims InteractionsVolume 4Issue 6Nov./Dec. 1997 pp 42–61https://doi.org/10.1145/267505.267514Published:01 November 1997Publication History 211citation6,901DownloadsMetricsTotal Citations211Total Downloads6,901Last 12 Months685Last 6 weeks107 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Origin of Fracture‐Resistance to Large Volume Change in Cu‐Substituted Co3O4 Electrodes (2017)

The electrode materials conducive to conversion reactions undergo large volume change in cycles which restrict their further development. It has been demonstrated that incorporation of a third element into metal oxides can improve the cycling stability while the mechanism remains unknown. Here, an in situ and ex situ electron microscopy investigation of structural evolutions of Cu-substituted Co<sub>3</sub> O<sub>4</sub> supplemented by first-principles calculations is reported to reveal the mechanism. An interconnected framework of ultrathin metallic copper formed provides a high conductivity backbone and cohesive support to accommodate the volume change and has a cube-on-cube orientation relationship with Li<sub>2</sub> O. In charge, a portion of Cu metal is oxidized to CuO, which maintains a cube-on-cube orientation relationship with Cu. The Co metal and oxides remain as nanoclusters (less than 5 nm) thus active in subsequent cycles. This adaptive architecture accommodates the formation of Li<sub>2</sub> O in the discharge cycle and underpins the catalytic activity of Li<sub>2</sub> O decomposition in the charge cycle.
A Randomized Double-Blind Placebo-Control Study to Assess the Efficacy and Safety of OLNP-05 Versus Placebo for the Treatment of Subjects with Premature Ejaculation (2020)

Premature ejaculation (PE) is one of the foremost sex-related health problems among men. The global occurrence ranges from 20% to 30%, according to various studies. PE has a great impact on the men's quality of life, with deleterious effects such as embarrassment, frustration, and feeling of incompetence. Considering the necessity of treatment of PE, this study was planned to compare the efficacy and safety of OLNP-05 versus placebo for treating subjects suffering from PE. In this randomized clinical study, 60 men with PE were enrolled and randomly assigned to receive either OLNP-05 or placebo one capsule twice daily for a period of 8 weeks. Subjects were evaluated during visits on day 1, day 28, and day 56. Mean change from baseline in intravaginal ejaculatory latency time (IELT), improvement in premature ejaculation profile (PEP), and Clinical Global Impression-Improvement scale (CGI-I) were used to assess the efficacy of treatment. <i>P</i>-value <.05 was considered significant. At the end of the treatment, the improvement in IELT score in the OLNP-05 group was remarkably higher than the placebo. Subjects in the OLNP-05 treatment group also reported significantly greater improvement in PEP subscale score. Majority of OLNP-05-treated subjects were found to be in the "much improved" category as per CGI-I assessment. The result confirms the safety and efficacy of OLNP-05, therefore suggesting that OLNP-05 may be a safe and effective intervention for the management of PE. <b>Trial registration:</b> Clinical Trials Registry India (Registration No: CTRI/2017/08/009226, 02/08/2017).
Society for Cardiovascular Angiography and Interventions Shock Classification to Stratify Outcomes of Extracorporeal Membrane Oxygenation (2022)

We applied the Society for Cardiovascular Angiography and Interventions (SCAI) schema to cardiogenic shock (CS) patients treated with venoarterial extracorporeal membrane oxygenation (VA-ECMO) to assess performance in this high acuity group of patients. Records of adult patients receiving VA-ECMO for CS at our institution from 01/2015 to 12/2019 were reviewed. Post-cardiotomy and noncardiogenic shock patients were excluded. A total of 245 patients were included, with a median age of 59 years [IQR: 48-67]; 159 (65%) were male. There were 34 (14%) patients in Stage C, 82 (33%) in D, and 129 (53%) in E. Of E patients, 88 (68%) were undergoing cardiopulmonary resuscitation. Median ECMO duration decreased with stage (C:7, D:6, E:4 days, P < 0.001). In-hospital mortality increased (C:35%, D:56%, E:71%, P < 0.001) and myocardial recovery decreased with stage (C:65%, D:35%, E:30%, P < 0.001). Acute kidney injury (C:35%, D:45%, E:54%, P = 0.045), acute liver failure (C:32%, D:66%, E:76%, P < 0.001), and infection (C:35%, D:28%, E:16%, P = 0.004) varied among groups. Multivariable analysis revealed age (HR=1.02), male sex (HR=0.62), and E classification (HR=2.69) as independently associated with 1-year mortality. Competing-risks regression identified D (SHR=0.53) and E classification (SHR=0.45) as inversely associated with myocardial recovery. In patients treated with VA-ECMO for CS, the SCAI classification provided robust risk stratification.
Inhibition of human phospholipase C by aurothiomalate and (triethylphosphine) gold complexes. (1992)

The effect of several gold complexes on the activity of phospholipase C from human blood platelets was studied in vitro. Aurothiomalate and auranofin--2 agents used for the chrysotherapy of rheumatoid arthritis--, gold chloride, (triethylphosphine)gold chloride, and 5 newly synthesized (triethylphosphine)gold complexes dose-dependently inhibited the enzyme with IC50 values between 0.8 mumol/l ((triethylphosphine)gold chloride) and over 100 mumol/l (auranofin). None of the compounds affected phospholipase A2 from human polymorphonuclear leukocytes at concentrations up to 100 mumol/l. Inhibition of phospholipase C by (triethylphosphine)gold chloride, aurothiomalate, and compound 3 was not significantly different at substrate concentrations of 20 and 100 mumol/l phosphatidylinositol, suggesting that these gold complexes do not inhibit phospholipase C by competing with the substrate. After confirming the Ca2+ dependence of the human platelet phospholipase C by demonstrating inhibition by the Ca2+ chelators EDTA and EGTA--but no inhibition by the Zn2+ chelator 1,10-phenanthroline--the inhibition of the enzyme by (triethylphosphine)gold chloride, aurothiomalate, and compound 3 was studied at 3 different concentrations of Ca2+ in the range of 0.2 to 2 mmol/l. Inhibition by (triethylphosphine)gold chloride was not affected by changes of Ca2+, whereas inhibition by aurothiomalate and compound 3 was markedly suppressed by increasing the Ca2+ concentration.(ABSTRACT TRUNCATED AT 250 WORDS)