gebhart/patrepeval huggingface dataset:
Reductive acceleration of the migratory insertion reaction: evidence that insertion occurs in a 19-electron intermediate (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReductive acceleration of the migratory insertion reaction: evidence that insertion occurs in a 19-electron intermediateBernadette T. Donovan and William E. GeigerCite this: Organometallics 1990, 9, 3, 865–866Publication Date (Print):March 1, 1990Publication History Published online1 May 2002Published inissue 1 March 1990https://pubs.acs.org/doi/10.1021/om00117a054https://doi.org/10.1021/om00117a054research-articleACS PublicationsRequest reuse permissionsArticle Views93Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Spread of symptoms in idiopathic torsion dystonia (1995)

We reviewed the histories of 115 patients who had idiopathic dystonia and who were 21 years of age and younger at onset of symptoms and 472 patients with onset older than age 21. Patients with onset in the lower extremities tended to be younger at onset (mean age 8.4 years), have rapid spread of symptoms to other body parts, and to develop generalized dystonia. Patients with onset in the upper extremities tended to be older at onset (mean age 11.2 years) and were less likely to develop generalized dystonia, but were more likely to experience spread of symptoms many years after the disease began. Almost 20% of patients younger than age 22 began with torticollis, and 67% of these remained focal after a mean 14.9 years. In adults, dystonic symptoms remained focal in the majority, but approximately 15-30% of patients presenting with blepharospasm, torticollis, laryngeal or brachial dystonia eventually experienced dystonia outside the initially involved segment. Almost 50% of children and adolescents with dystonia reported a family history of dystonia, compared with approximately 10-13% of patients with torticollis, laryngeal or brachial dystonia. Less than 3% of patients with blepharospasm reported a family history of dystonia. There were only minor differences in the pattern of spread of dystonic symptoms between Jewish and non-Jewish patients. Although younger patients were more likely to report a family history of dystonia, patterns of spread were the same for familial and sporadic patients in the same age range.
Nitric Oxide Mediates Activity-Dependent Plasticity of Retinal Bipolar Cell Output via S-Nitrosylation (2013)

Coding a wide range of light intensities in natural scenes poses a challenge for the retina: adaptation to bright light should not compromise sensitivity to dim light. Here we report a novel form of activity-dependent synaptic plasticity, specifically, a "weighted potentiation" that selectively increases output of Mb-type bipolar cells in the goldfish retina in response to weak inputs but leaves the input-output ratio for strong stimuli unaffected. In retinal slice preparation, strong depolarization of bipolar terminals significantly lowered the threshold for calcium spike initiation, which originated from a shift in activation of voltage-gated calcium currents (ICa) to more negative potentials. The process depended upon glutamate-evoked retrograde nitric oxide (NO) signaling as it was eliminated by pretreatment with an NO synthase blocker, TRIM. The NO-dependent ICa modulation was cGMP independent but could be blocked by N-ethylmaleimide (NEM), indicating that NO acted via an S-nitrosylation mechanism. Importantly, the NO action resulted in a weighted potentiation of Mb output in response to small (≤-30 mV) depolarizations. Coincidentally, light flashes with intensity ≥ 2.4 × 10(8) photons/cm(2)/s lowered the latency of scotopic (≤ 2.4 × 10(8) photons/cm(2)/s) light-evoked calcium spikes in Mb axon terminals in an NEM-sensitive manner, but light responses above cone threshold (≥ 3.5 × 10(9) photons/cm(2)/s) were unaltered. Under bright scotopic/mesopic conditions, this novel form of Mb output potentiation selectively amplifies dim retinal inputs at Mb → ganglion cell synapses. We propose that this process might counteract decreases in retinal sensitivity during light adaptation by preventing the loss of visual information carried by dim scotopic signals.
A 15-year study of the role of Aeromonas spp. in gastroenteritis in hospitalised children (1992)

During a 15-year period, 146 strains of Aeromonas spp. were isolated from 32810 faecal specimens from 13,820 hospitalised patients up to 13 years of age. These isolates constituted 4% of all the pathogenic bacterial strains cultured. For the years 1978-1988, the files of children with gastro-enteritis revealed 81 whose faeces yielded Aeromonas spp. Most of them (94%) were < 3 years of age, 78% < 1 year old. The peak incidence was at 2-6 months, involving severe morbidity including dehydration and vomiting with acidaemia and azotaemia; the mean duration of illness and length of hospitalisation at this age were longer than at other ages. Bloody diarrhoea was found in 7% of the children. Almost all the strains of Aeromonas were resistant to ampicillin. We conclude that Aeromonas spp. are of aetiological significance in gastro-enteritis in small children; culture for this pathogen should be routine in the bacteriological examination of faeces.
ChemInform Abstract: Monodisperse 3d Transition‐Metal (Co, Ni, Fe) Nanoparticles and Their Assembly into Nanoparticle Superlattices. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Maintenance of Taste Organs Is Strictly Dependent on Epithelial Hedgehog/GLI Signaling (2016)

For homeostasis, lingual taste papilla organs require regulation of epithelial cell survival and renewal, with sustained innervation and stromal interactions. To investigate a role for Hedgehog/GLI signaling in adult taste organs we used a panel of conditional mouse models to manipulate GLI activity within epithelial cells of the fungiform and circumvallate papillae. Hedgehog signaling suppression rapidly led to taste bud loss, papilla disruption, and decreased proliferation in domains of papilla epithelium that contribute to taste cells. Hedgehog responding cells were eliminated from the epithelium but retained in the papilla stromal core. Despite papilla disruption and loss of taste buds that are a major source of Hedgehog ligand, innervation to taste papillae was maintained, and not misdirected, even after prolonged GLI blockade. Further, vimentin-positive fibroblasts remained in the papilla core. However, retained innervation and stromal cells were not sufficient to maintain taste bud cells in the context of compromised epithelial Hedgehog signaling. Importantly taste organ disruption after GLI blockade was reversible in papillae that retained some taste bud cell remnants where reactivation of Hedgehog signaling led to regeneration of papilla epithelium and taste buds. Therefore, taste bud progenitors were either retained during epithelial GLI blockade or readily repopulated during recovery, and were poised to regenerate taste buds once Hedgehog signaling was restored, with innervation and papilla connective tissue elements in place. Our data argue that Hedgehog signaling is essential for adult tongue tissue maintenance and that taste papilla epithelial cells represent the key targets for physiologic Hedgehog-dependent regulation of taste organ homeostasis. Because disruption of GLI transcriptional activity in taste papilla epithelium is sufficient to drive taste organ loss, similar to pharmacologic Hedgehog pathway inhibition, the findings suggest that taste alterations in cancer patients using systemic Hedgehog pathway inhibitors result principally from interruption of signaling activity in taste papillae.
Screw Theory Based Metrology for Design and Error Compensation of Machine Tools (2001)

Abstract The paper presents a generalized mathematical framework for computation and compensation of tool tip errors in multi-axis machine tools using screw theory. In contrast to conventional Denavit–Hartenberg notation, Screw theory offers several advantages including: (i) modeling of complex machine tool configurations with rotational axes, (ii) tractability of error propagation which simplifies solution of inverse kinematics and subsequent error-compensation procedures, and (iii) functional representation of error screws in a global reference frame rather than cumbersome coordinate transformations of local reference frames. Kinestatic filtering technique [11,12] is adopted for evaluating the compensatability of errors and the Jacobian is used for error compensation. The methodology is illustrated using a five-axis machine tool with two rotational axes.
A Study of Mode-Matching and Alignment In Piezoelectric Disk Resonator Gyros Via Femtosecond Laser Ablation (2021)

A mode-matching and alignment algorithm for bulk acoustic wave (BAW) resonator gyroscopes via femtosecond laser ablation is presented in this paper and verified on a piezoelectrically-actuated AlN-on-Si disk resonator. Mode-matching is essential to operate piezoelectric BAW resonators as gyros with high sensitivity in air but challenging due to the lack of electrostatic spring-softening effect. In this work, a laser trimming algorithm is implemented to mechanically mode-match and align the two resonant modes of a disk resonator guided by novel numerical maps. After selective laser ablation trimming, the as-born frequency split of 191Hz between 1.4MHz modes of a disk due to fabrication imperfections is reduced to 12Hz, corresponding to 3.8% of its -3dB resonant bandwidth while maintaining a Q-factor of 4600 in air, and 30dB improvement in mode isolation. The laser-trimmed frequencies remain closely matched across the temperature range of -30°C to 90°C, verifying the temperature robustness of laser trimming results. The mode-matched disk resonator is operated as a gyroscope in air and exhibits a large scale factor of 4.12nA/°/s.
ChemInform Abstract: Reactions of Abietic Acid Methyl Ester with m‐Chloroperbenzoic Acid. (1986)

Abstract Depending on the reaction conditions, epoxidation of the title compound (I) yields principally or exclusively the monoepoxides (II) and (III).
Improved pentamethine cyanine nanosensors for optoacoustic imaging of pancreatic cancer (2021)

Optoacoustic imaging is a new biomedical imaging technology with clear benefits over traditional optical imaging and ultrasound. While the imaging technology has improved since its initial development, the creation of dedicated contrast agents for optoacoustic imaging has been stagnant. Current exploration of contrast agents has been limited to standard commercial dyes that have already been established in optical imaging applications. While some of these compounds have demonstrated utility in optoacoustic imaging, they are far from optimal and there is a need for contrast agents with tailored optoacoustic properties. The synthesis, encapsulation within tumor targeting silica nanoparticles and applications in in vivo tumor imaging of optoacoustic contrast agents are reported.
Regioselective synthesis of functionalized 3,5-diketoesters and 2,4-diketosulfones by uncatalyzed condensation of 1-methoxy-1,3-bis(trimethylsilyloxy)-1,3-butadienes with α,β-unsaturated acid chlorides and sulfonyl chlorides (2008)

The reaction of 1-methoxy-1,3-bis(trimethylsilyloxy)-1,3-butadienes with alpha,beta-unsaturated and functionalized acid chlorides afforded a variety of 3,5-diketoesters which are not readily available by other methods. The reaction of 1-methoxy-1,3-bis(trimethylsilyloxy)-1,3-butadiene with sulfonyl chlorides allows a direct synthesis of 2,4-diketosulfones.
Carpegen® real‐time polymerase chain reaction vs. anaerobic culture for periodontal pathogen identification (2006)

Good results were obtained with the real-time PCR technique for the six periopathogens targeted. This method seems to be indicated for its simplicity, rapidity and reproducibility but it cannot analyze data for an antibiotic susceptibility test. The periodontist must therefore choose one of these two methods according to his specific clinical objective: to obtain rapid, specific detection even with weak initial concentrations (but for targeted periopathogens only) or to be non-specific and analyze the pathological activity with an antibiogram.
A 1-V, self adjusting, 5-MHz CMOS RC-oscillator (2003)

A 5-MHz, self adjusting CMOS RC-oscillator for portable biomedical applications is presented. The oscillator is capable of operating. with a 1-V power supply and it features low current consumption (20 /spl mu/A @ 1 V) and low sensitivity to supply voltage and temperature variations. The total accuracy of the oscillator is within 5 % with component tolerances of 1 % in external elements R and C. The design was fabricated in a 0.35 /spl mu/m n-well standard digital CMOS process with threshold voltages of 0.5 V and -0.65 V. The design and the operation of the RC-oscillator with measurement results of fabricated chips are presented.
Semantic Adaptation of Multimedia Content (2006)

The increasing diversity of devices and the heterogeneity of networks pose nowadays a challenge in the delivery and consumption of multimedia content. In this context, the part 7 of the MPEG-21 standard formally named digital item adaptation (DIA) targets the adaptation of multimedia content based on usage environment, such as network characteristics, terminal capabilities and user characteristics. But, MPEG-21 DIA does not take into account MPEG-7 semantics description tools, which provide means for a conceptual (semantic) description that is close to the human understanding of multimedia content. Therefore, to fill this gap, we proposed and implemented an interactive and user-centric framework called semantic adaptation framework (SAF). The SAF provides facilities for the generation of all the required semantic metadata and enables an MPEG-21 adaptation engine to semantically adapt the multimedia content in order to provide the user with the best possible experience
Assessment of Primary Care Clinician Concordance With Guidelines for Use of Magnetic Resonance Imaging in Patients With Nonspecific Low Back Pain in the Veterans Affairs Health System (2020)

VA primary care clinics had low rates of use of early MRI scans. A history of low concordance with imaging guidelines was associated with subsequent low concordance but with limited potential to select clinicians most in need of interventions to implement guidelines.
Wax-type Molding Aid for Preparation of Cermet (2012)

On the preparetion of Ti(C0.7N0.3)-19 mass%Mo2C-24 mass%Ni cermet, solid paraffin, liquid paraffin and wax-emulsion were selected for the aid of press-molding. The properties of green and sintered compacts using these molding aids were investigated. The obtained results were summrized as follows. (1) As the result of thermal dewaxing for φ 50 mm×H 50 mm columnar-shaped green compact, the cracks on the compact after dewaxed was hard to occur using liquid paraffin and wax-emulsion. (2) The green compact by wax-emulsion had higher bending strength than those by other molding aids. (3) The sintered compact by liquid paraffin had more homogeneous microstructure and higher transverse rapture strength of 1.59 GPa than those by other molding aids. (4) The addition of deflocculant to the wax-emulsion decreased the viscosity of suraly after wet milling and enhanced the transverse rapture strength of the sintered compact to 1.88 GPa.
Hyperglycosylated hCG in the Management of Quiescent and Chemorefractory Gestational Trophoblastic Diseases (2010)

The presence of minimal or no hyperglycosylated human chorionic gonadotropin (hCG) is a characteristic feature of 2 gestational trophoblastic diseases (GTDs), quiescent GTD and minimally invasive GTD. Quiescent or inactive GTD is an inactive stable nonmalignant, noninvasive condition, whereas minimally invasive GTD is defined by slow rising total hCG with a doubling rate of 2 to 6 weeks, by <40% hyperglycosylated hCG of total hCG, and by resistance to chemotherapy The USA hCG Reference Service has characterized both disorders and recently presented a new approach to treatment of minimally invasive GTD. This approach is based on data showing that withholding therapy and allowing patients to advance to an hCG level of about 3000 IU/L increases the cytotrophoblast proportions of trophoblasts, thereby elevating the percent of hyperglycosylated hCG and improving the likelihood of complete response from chemotherapy. This retrospective cohort study assessed the role of hyperglycosylated hCG in the diagnosis and management of quiescent, aggressive and minimally invasive GTD. The USA hCG Reference Service was consulted for 197 cases with GTD. Of these, 133 were cases shown to be quiescent or inactive disease, 35 were found to be aggressive GTD and 30 minimally invasive. Among the 133 cases with quiescent GTD, no hyperglycosylated hCG was detected in 127, and 4% to 27% hyperglycosylated hCG was detected in the remaining 6. Of the 35 cases with aggressive GTD (as indicated by high hyperglycosylated hCG, >40%), only 1 was resistant to chemotherapy. In sharp contrast, all 30 of the minimally invasive cases (with low hyperglycosylated hCG, <40%) were chemorefractory; characteristically, hCG increased very slowly in these cases with a doubling time of 3.4 ± 2.3 weeks. The proportion of hyperglycosylated hCG increased with advancing disease. Withholding initiation of therapy until the hCG exceeded 3000 IU/L was successful in 100% (10/10) of minimally invasive cases. These findings show that determination of the proportion of hyperglycosylated hCG allows division of cases of GTD into quiescent, minimally invasive and aggressive disease and the subsequent adjustment of therapy critical for management. Quiescent GTD has little or no hyperglycosylated hCG and requires no therapy. Because minimally invasive disease is chemorefractory, the USA hCG Reference Service recommends withholding initiation of chemotherapy until hCG exceeds 3000 IU/L.
Integrated power conditioner topology for fuel cell based power supply systems (2008)

In this paper it is presented a new integrated power conditioner topology proposed for a fuel cell based on power supply system. The proposed converter combines the conventional ZVS active clamp full bridge boost converter structure with the sinusoidal pulse width modulation technique to guarantee a sinusoidal output voltage. Particularly, the proposed fuel cell power conditioner is intended for stand-alone AC power generation and low voltage fuel cell input. The main characteristic of the proposed topology is the use of fewer components when compared to the conventional two-stage power conditioners approach reducing the cost. In addition, the total efficiency is increased by reducing the power processing stages. Therefore, it is expected that the proposed integrated power conditioner topology could be effectively utilized for fuel cells applications. It is also presented a compressive analysis of the main characteristics of the fuel cell which will determine the design parameters for the power conditioner. In order to validate the proposed approach, simulation and experimental results are provided for a 100 W integrated power conditioner prototype with 120 V ac output voltage and 26 V dc input voltage.
A fully digital feedback equalizer for MDFE read channel (2003)

The design of a feedback equalizer (FE) in multi-level decision feedback equalization (MDFE) for magnetic recording channels is presented. The fully digital feedback equalizer is implemented with a look-up-table based architecture. The FE has 11 taps where the past decisions are stored and subsequently used to determine the feedback coefficients. With the insertion of a single pipeline, two clock periods are allowed for the completion of the critical timing loop. The improvement in throughput is made possible with the application of look-ahead computation. Based on a 0.35 /spl mu/m CMOS technology, the post-layout simulation results show that the FE is capable of operating at a clock rate of 132 MHz under typical conditions.
An approach for a component-based visualization of heterogeneous manufacturing data sources (2012)

The analysis of modern production environments requires a clear and understandable uniform visualization of the information from all levels of the production. This visualization has to be on the one hand light weight to avoid cognitive overload of the users and on the other hand rich enough to provide information about all production information sources. To solve this issue we propose to use a unified component-based visualization where single items can be exchanged to fulfill the informational needs of the users from heterogeneous data sources.
N-Acetylglucosaminyltransferase V Expression Levels Regulate Cadherin-associated Homotypic Cell-Cell Adhesion and Intracellular Signaling Pathways (2003)

A common glycan alteration in transformed cells and human tumors is the highly elevated levels of N-linked beta(1,6)glycans caused by increased transcription of N-acetylglucosaminyltransferase V (GnT-V). Here, we define the involvement of GnT-V in modulation of homotypic cell-cell adhesion in human fibrosarcoma HT1080 and mouse NIH3T3 cells. Increased GnT-V expression resulted in a significant decrease in the rates of calcium-dependent cell-cell adhesion. Reduced cell-cell adhesion was blocked by function-blocking antibody against N-cadherin and abrogated by pre-treatment of cells with swainsonine, demonstrating the involvement of N-cadherin in the cell-cell adhesion and that changes in N-linked beta(1,6)glycan expression are responsible for the reduction in rates of adhesion, although this reduction could be mediated by the altered N-linked glycosylation of glycoproteins other than N-cadherin. Overexpression of GnT-V had no effect on the levels of cell surface expression of N-cadherin; however, it did cause a marked enhancement of both beta(1,6) branching and poly-N-acetyllactosamine expression on N-cadherin. GnT-V overexpression resulted in decreased N-cadherin clustering on the cell surface induced by anti-N-cadherin antibody and affected the outside-in signal transduction pathway of ERK mediated by N-cadherin. Overexpression of GnT-V sensitized stimulation of tyrosine phosphorylation of catenins by growth factors and expression of v-src, which is consistent with its reduction of cell-cell adhesion. In vitro, GnT-V-overexpressing cells showed increased motility concomitant with increased phosphorylation of catenins. Moreover, GnT-V-deficient embryo fibroblasts from GnT-V homozygous null mice (GnT-V(-/-)) express N-cadherin and showed significantly increased levels of N-cadherin-based cell-cell adhesion compared with those from GnT-V(+/-) mice. These levels of adhesion were inhibited significantly by transient expression of GnT-V, confirming the hypothesis that levels of GnT-V can regulate cadherin-associated homotypic cell-cell adhesion. Aberrant N-linked beta(1,6) branching that occurs during oncogenesis can, therefore, lessen cell-cell adhesion, contributing to increased cellular motility and invasiveness.