gebhart/patrepeval huggingface dataset:
Two-particle correlations on transverse momentum and momentum dissipation in Au–Au collisions at = 130 GeV (2007)

Measurements of two-particle correlations on transverse momentum p t for Au-Au collisions at s NN = 130 GeV are presented. Significant largemomentum-scale correlations are observed for charged primary hadrons with 0.15 p t 2 GeV/c and pseudorapidity || 1.3. Such correlations were not observed in a similar study at lower energy and are not predicted by theoretical collision models. Their direct relation to mean-p t fluctuations measured in the same angular acceptance is demonstrated. Positive correlations are observed for pairs of particles which have large p t values while negative correlations occur for pairs in which one particle has large p t and the other has much lower p t . The correlation amplitudes per final state particle increase with
A phase 1 healthy male volunteer single escalating dose study of the pharmacokinetics and pharmacodynamics of risdiplam (RG7916, RO7034067), a SMN2 splicing modifier (2018)

Risdiplam was well tolerated and proof of mechanism was demonstrated by the intended shift in SMN2 splicing towards full-length SMN2 mRNA. Based on these data, Phase 2/3 studies of risdiplam in patients with SMA are now ongoing.
Single-mode photonic crystal waveguides for RF delay generation (2006)

The group delay in low-loss, single-mode, 1-mm-long photonic crystal slab waveguides is measured using the phase-shift technique. Slow modes appear a promising approach for compact and massively integrated optical delay lines for signal processing.
<title>Resolution enhancement and performance characteristics of large-area a-Si:H x-ray imager with a high-aspect-ratio SU-8 micromold</title> (2002)

Hydrogenated amorphous silicon is known for its large area imaging applications because of its high photoconductivity and high absorption coefficient in the visible light range. This material can be also applied to X-ray imaging when coupled with a uniform scintillation (e.g. Gd2O2S phosphor) film integrated on top of a 2-D detection array. A thick phosphor layer is the prerequisite for high X-ray conversion efficiency. In reality, however, there may be significant crosstalk between adjacent pixels thus undermining spatial resolution. This paper introduces a high aspect ratio microstructure with the new photoresist SU-8 epoxy, which limits the phosphor to regions above the photodiodes. The differences between the above scheme and that of a continuous phosphor layer are compared in terms of the absorption efficiency, the conversion efficiency, and the modulation transfer function (MTF). The measurements are carried out in a medical testing environment with X-ray source voltages of 40-120kVp. The results show a great improvement in the spatial resolution.
[Efficacy of the paramunity inducers PIND-AVI and PIND-ORF as radioprotective agents]. (1985)

A significant reduction of mortality after lethal irradiation (7,8 and 9 Gy X-ray total-body irradiation) was achieved by continuous therapeutic subcutaneous application of the biologic inducers PIND-AVI and PIND-ORF. This was obtained by a stimulation of the investigated spleen parameters and a stimulation of leucocytes and phagocytosis. The inducers had no significant influence on the radiogenic reduction of blood cells and bone marrow cells, of the relative spleen and thymus weight and of the DNA and protein level of spleen and thymus. The regeneration of blood leucocytes (preponderantly by PIND-AVI) and of the spleen (preponderantly by PIND-ORF) was accelerated, but not the thymus regeneration which was already rather low. The leucocyte phagocytosis which increased generally after irradiation was markedly stimulated by paramunization. This stimulation was also observed after a latent time in animals submitted to sham irradiation. Its temporal appearance and its quantitative and qualitative properties corresponded to the effects of inducers after X-ray irradiation. Both inducers were found to be harmless in all experiments.
The T Cell-Specific CXC Chemokines IP-10, Mig, and I-TAC Are Expressed by Activated Human Bronchial Epithelial Cells (1999)

Recruitment of activated T cells to mucosal surfaces, such as the airway epithelium, is important in host defense and for the development of inflammatory diseases at these sites. We therefore asked whether the CXC chemokines IFN-induced protein of 10 kDa (IP-10), monokine induced by IFN-gamma (Mig), and IFN-inducible T-cell alpha-chemoattractant (I-TAC), which specifically chemoattract activated T cells by signaling through the chemokine receptor CXCR3, were inducible in respiratory epithelial cells. The effects of proinflammatory cytokines, including IFN-gamma (Th1-type cytokine), Th2-type cytokines (IL-4, IL-10, and IL-13), and dexamethasone were studied in normal human bronchial epithelial cells (NHBEC) and in two human respiratory epithelial cell lines, A549 and BEAS-2B. We found that IFN-gamma, but not TNF-alpha or IL-1 beta, strongly induced IP-10, Mig, and I-TAC mRNA accumulation mainly in NHBEC and that TNF-alpha and IL-1 beta synergized with IFN-gamma induction in all three cell types. High levels of IP-10 protein (> 800 ng/ml) were detected in supernatants of IFN-gamma/TNF-alpha-stimulated NHBEC. Neither dexamethasone nor Th2 cytokines modulated IP-10, Mig, or I-TAC expression. Since IFN-gamma is up-regulated in tuberculosis (TB), using in situ hybridization we studied the expression of IP-10 in the airways of TB patients and found that IP-10 mRNA was expressed in the bronchial epithelium. In addition, IP-10-positive cells obtained by bronchoalveolar lavage were significantly increased in TB patients compared with normal controls. These results show that activated bronchial epithelium is an important source of IP-10, Mig, and I-TAC, which may, in pulmonary diseases such as TB (in which IFN-gamma is highly expressed) play an important role in the recruitment of activated T cells.
Conditionally sampled measurements in a heated turbulent jet (1975)

Measurements of velocity fluctuations u (axial) and v (radial) and temperature fluctuations θ averaged over the turbulent zone have been made in a turbulent heated jet with a co-flowing stream and compared with the conventionally averaged results. The zone-averaged mean temperature and temperature fluctuation intensity appear to be nearly homogeneously distributed in the outer, intermittent region of the jet. This homogeneity does not apply to the u and v fluctuations. The flatness factor of the temperature within the turbulent part of the flow is remarkably constant throughout the intermittent region. Although the skewness of the turbulent θ fluctuations is non-zero, it is smaller than the skewness of the turbulent u and v fluctuations. The average $\overline{\theta v}$ of the heat flux over the turbulent zone increases in the intermittent region whereas the zone-averaged momentum flux $\overline{uv}$ and zone-averaged heat flux $\overline{\theta u}$ continuously decrease. This leads to the Prandtl number of the turbulent fluid being smaller than the conventional Prandtl number in the outer part of the flow. A budget for the square of the temperature fluctuations within the turbulent part of the flow indicates a constant distribution of temperature dissipation. The transport of heat by the large-scale structure of the flow is briefly discussed in the light of available experimental information on other turbulent shear flows.
Optical techniques for microwave frequency stabilization : resonant versus delay line approaches and related modelling problems (2008)

International audience
The Effect of Antisecretagogues on Gastric Microflora (1983)

We examined the effect of cimetidine in altering gastric microflora in patients undergoing gastric resection for peptic ulcer disease. Ten patients had administration of cimetidine stopped at least six hours before surgery. Their mean gastric pH was 2.02 +/- 1.51, and 0.4 +/- 0.97 organisms were isolated per patient. Ten patients were maintained on a regimen of cimetidine and their mean gastric pH was 5.69 +/- 1.80, with 3.2 +/- 1.62 organisms isolated per patient. We reached the following conclusions: cimetidine alters the gastric pH of preoperative patients; cimetidine therapy is associated with an increase in gastric flora; stopping administration of cimetidine six hours before surgery reacidifies the stomach, decreases the number of organisms isolated from the stomach, and decreases the risk of septic complications.
Multi-Sensor Vibration Signal Based Three-Stage Fault Prediction for Rotating Mechanical Equipment (2022)

In order to reduce maintenance costs and avoid safety accidents, it is of great significance to carry out fault prediction to reasonably arrange maintenance plans for rotating mechanical equipment. At present, the relevant research mainly focuses on fault diagnosis and remaining useful life (RUL) predictions, which cannot provide information on the specific health condition and fault types of rotating mechanical equipment in advance. In this paper, a novel three-stage fault prediction method is presented to realize the identification of the degradation period and the type of failure simultaneously. Firstly, based on the vibration signals from multiple sensors, a convolutional neural network (CNN) and long short-term memory (LSTM) network are combined to extract the spatiotemporal features of the degradation period and fault type by means of the cross-entropy loss function. Then, to predict the degradation trend and the type of failure, the attention-bidirectional (Bi)-LSTM network is used as the regression model to predict the future trend of features. Furthermore, the predicted features are given to the support vector classification (SVC) model to identify the specific degradation period and fault type, which can eventually realize a comprehensive fault prediction. Finally, the NSF I/UCR Center for Intelligent Maintenance Systems (IMS) dataset is used to verify the feasibility and efficiency of the proposed fault prediction method.
Ecosystem Deep Dive #1: Investment—The Role of Financial Services (2019)

The circular economy requires substantial investments in a range of areas, from supporting start-ups experimenting with new circular business models to developing large-scale recycling infrastructure. The capital that will underpin the shift to new circular business models far outweighs what is readily available and accessible. By investing in circular initiatives, financial services companies can gain competitive advantage in three important ways: achieving growth, differentiating from competitors, securing license to operate, and mitigating risk. New types of financial metrics and instruments are needed to properly evaluate and fund circular initiatives. Financial institutions should find better ways to evaluate risk and use blended financial models to mitigate risk. Banks and lenders should collaborate with their clients to help them develop the business case for circular projects and better identify and quantify costs and benefits.
Complex Genetics and the Etiology of Human Congenital Heart Disease (2014)

Congenital heart disease (CHD) is the most common birth defect. Despite considerable advances in care, CHD remains a major contributor to newborn mortality and is associated with substantial morbidities and premature death. Genetic abnormalities appear to be the primary cause of CHD, but identifying precise defects has proven challenging, principally because CHD is a complex genetic trait. Mainly because of recent advances in genomic technology such as next-generation DNA sequencing, scientists have begun to identify the genetic variants underlying CHD. In this article, the roles of modifier genes, de novo mutations, copy number variants, common variants, and noncoding mutations in the pathogenesis of CHD are reviewed.
<title>APART/PADE Version 7: A Deterministic Computer Program Used To Calculate Scattered And Diffracted Energy</title> (1981)

The APART/PADE (Arizona&apos;s Paraxial Analysis of Radiation Transfer/Program for the Analysis of Diffracted Energy) code is a deterministic stray radiation analysis program capable of yielding quantitative descriptions of systems along with providing insight about the propagation paths. The program can be used to determine the image plane distribution due to external point sources, external extended sources such as the Earth, and for internally emitted radiation. The inclusion of the PADE program allows not only pure diffraction paths to be evaluated but also mixed modes of diffraction and scatter in any order. The program handles a large class of asymmetrical optical sensors and is designed to be most efficient with rotationally symmetric systems. Many additional related features of the program are discussed.
Effect of NaCl on nitrate removal from ion-exchange spent brine in the membrane biofilm reactor (MBfR) (2012)

The H(2)-based membrane biofilm reactor was used to remove nitrate from synthetic ion-exchange brine at NaCl concentrations from ∼3 to 30 g/L. NaCl concentrations below 20 g/L did not affect the nitrate removal flux as long as potassium was available to generate osmotic tolerance for high sodium, the H(2) pressure was adequate, and membrane fouling was eliminated. Operating pHs of 7-8 and periodic citric acid washes controlled membrane fouling and enabled reactor operation for 650 days. At 30 psig H(2) and high nitrate loading rates of 15 to 80 g/m(2) d, nitrate removal fluxes ranged from 2.5 to ∼6 g/m(2) d, which are the highest fluxes observed when treating 30 g/L IX brine. However, percent removals were low, and the H(2) pressure probably limited the removal flux.
Application of an Unsteady-State Pulp-Partition Model to Dense-Medium Separations (1989)

Abstract Since there has been a growing interest in using gravity concentration techniques for the processing of fine coal (less than about 0.5 mm in size), it is important that a performance prediction procedure is used which is capable of showing differences in the operating conditions of the separator. The generation of fractional recovery or partition curves is one such procedure. A fractional recovery curve is a plot of the fraction of or probability that a given size feed material of a given density reports to the product against the density. This paper derives a mathematical model, based upon the physics of the separation process, from which fractional recovery values can be obtained. The heart of this derivation is the convection-diffusion equation which takes into account both the settling and the mixing of particles within a free-settling-type separator. The fractional recovery curve can be obtained by fitting these values to an appropriate mathematical function. Although the fractional recovery curves can be described by model parameters such as viscosity, etc., the common industrial practice is to derive certain characteristic parameters directly from the curves. Therefore, if these values are fitted to an appropriate mathematical function, then the derived parameters can be obtained using a parameter estimation technique. Thus, by analyzing the variation of these parameters with operating and design conditions, a valuable technique for studying separator performance is established. Key words: fractional recoverypartition curvesgravity concentrationparameter estimationfree-settling
Original Article Utilization of Electrocardiographic P-wave Duration for AV Interval Optimization in Dual-Chamber Pacemakers (2010)

Background: Empiric programming of the atrio-ventricular (AV) delay is commonly performed during pacemaker implantation. Transmitral flow assessment by Doppler echocardiography can be used to find the optimal AV delay by Ritter's method, but this cannot easily be performed during pacemaker implantation. We sought to determine a non-invasive surrogate for this assessment. Since electrocardiographic P-wave duration estimates atrial activation time, we hypothesized this measurement may provide a more appropriate basis for programming AV intervals. Methods: A total of 19 patients were examined at the time of dual chamber pacemaker implantation, 13 (68%) being male with a mean age of 77. Each patient had the optimal AV interval determined by Ritter's method. The P-wave duration was measured independently on electrocardiograms using MUSE® Cardiology Information System (version 7.1.1). The relationship between P-wave duration and the optimal AV interval was analyzed. Results: The P-wave duration and optimal AV delay were related by a correlation coefficient of 0.815 and a correction factor of 1.26. The mean BMI was 27. The presence of hypertension, atrial fibrillation, and valvular heart disease was 13 (68%), 3 (16%), and 2 (11%) respectively. Mean echocardiographic parameters included an ejection fraction of 58%, left atrial index of 32 ml/m 2 , and diastolic dysfunction grade 1 (out of 4). Conclusions: In patients with dual chamber pacemakers in AV sequentially paced mode and normal EF, electrocardiographic P-wave duration correlates to the optimal AV delay by Ritter's method by a factor of 1.26.
Course on Simulation in Information Technology: the Global System for Mobile communications (2002)

Simulation in Information Technology is a course on system simulation that is offered by the Department of Information Technology to graduate students which are majoring in communications engineering. The course imparts a fundamental knowledge of simulation tools and of mobile communication systems. The simulation tool which is used in the course is COSSAP (Communication Systems Simulation and Analysis Package) and the considered communication system is GSM (Global System for Mobile communications). The authors give an introduction into COSSAP, into GSM and especially into the course structure. In addition, some simulation results are given, i.e. the improvement of soft decision decoding versus hard decision decoding.
The Truth About The Truth in Domain Names Act: Why this Recently Enacted Law is Unconstitutional, 23 J. Marshall J. Computer & Info. L. 141 (2004) (2004)

In April 2003 the Prosecutorial Remedies and other Tools to End the Exploitation of Children Today Act of 2003 (PROTECT Act) was enacted with the goal to protect children from abduction and abuse and achieve a more aggressive pursuit of the individuals committing crimes against the children. Although the AMBER Alert system is the most known portion of the legislation other provisions including the Truth in Domain Names Act (TDNA) making the use of a misleading Internet domain name to deceive a person to view pornography a criminal offense were also included. This comment first discusses the case of John Zuccarini, one of the most notorious typosquatters and the first person to be convicted under TDNA. It then proceeds in a more detailed examination of the Act explaining how the Act is overbroad for sevaral reasons. First because of its vague and undefined use of the word "misleading" as well as its treatment of warning pages, and the detrimental effects of such treatment; because it is vague about what evidences an "intent to deceive" and it lacks a provision excluding registrars. The author also discusses the TDNA's resemblance to a similar piece of legislation, the Child Online Protection Act, which was recently found to be overbroad. Finally, this comment concludes by determining that, in addition to being unconstitutionally vague and overbroad, the TDNA is somewhat unnecessary. Nevertheless, it is appropriate changes to the language of the Act are suggested as well as other possible means for regulating obscenity on the Internet.
European guideline for the management of hepatitis B and C virus infections, 2010 (2010)

These are the guidelines on hepatitis B and C management for IUSTI/WHO in Europe, 2010. They describe the epidemiology, diagnosis, clinical features, treatment and prevention of hepatitis B and C with particular reference to sexual health clinical practice.
EFFECT OF COLCHICINE ON THE DELAYED APPEARANCE OF LABELLED PROTEIN INTO SYNAPTOSOMAL SOLUBLE PROTEINS1 (1975)

Abstract— The effect of colchicine administration on the accumulation of radiolabelled soluble protein of brain synaptosomes was studied. Following injection of radiolabelled leucine, colchicine (injected bitemporally) was shown to block this delayed accumulation in limited brain areas. This effect supports the conclusion that the delayed appearance of label is a reflection of axoplasmic transport and demonstrates that colchicine can be utilized to block such transport in limited brain areas.
KIR2DL5 mutation and loss underlies sporadic dermal neurofibroma pathogenesis and growth (2017)

Dermal neurofibromas (DNFs) are benign peripheral nerve sheath tumors thought to originate from Schwann cell progenitors. These tumors represent one of the hallmarks of the neurofibromatosis type 1 (NF1) tumor predisposition syndrome, where they can number in the thousands. While NF1-DNFs arise due to mutations in the NF1 gene, the vast majority of DNFs occur sporadically (sp-DNFs), where the genetic etiology is currently unknown. Herein, we employed whole-exome sequencing of sp-DNFs to identify a recurrent mutation in the KIR2DL5 gene, which codes for a protein suppressor of natural killer (NK) cell activity. While the function of KIR2DL5 outside of the immune system is unknown, we identified a KIR2DL5N173D mutation in three of nine sp-DNFs, resulting in loss of KIR2DL5 protein expression. In contrast, two of these subjects had unrelated tumors, which retained KIR2DL5 protein expression. Moreover, loss of KIR2DL5 expression was demonstrated in 15 of 45 independently-identified sp-DNFs. Consistent with its potential role as a negative growth regulator important for neurofibroma maintenance, ectopic KIR2DL5N173D expression in normal human Schwann cells resulted in reduced KIR2DL5 expression and increased cell proliferation. Similarly, KIR2DL5 short hairpin RNA knockdown (KD) decreased KIR2DL5 protein levels and increased cell proliferation, as well as correlated with PDGFRβ and downstream RAS/AKT/mTOR hyperactivation. Importantly, inhibition of PDGFRβ or AKT/mTOR activity in KIR2DL5-KD human Schwann cells reduced proliferation to control levels. Collectively, these findings establish KIR2DL5 as a new Schwann cell growth regulator relevant to sp-DNF pathogenesis, which links sporadic and NF1-associated DNFs through RAS pathway hyperactivation.
Geometric Ring Annuloplasty for Aortic Valve Repair during Aortic Aneurysm Surgery (2018)

In preliminary regulatory studies, aortic ring annuloplasty seemed safe and effective during aortic aneurysm surgery. This approach could help standardize aortic valve repair.