gebhart/patrepeval huggingface dataset:
Induction of hepatocyte proliferation by retinoic acid (2004)

Retinoids have been shown to exert an anticarcinogenic effect through suppression of the cell cycle, induction of apoptosis and/or differentiation. In rat liver, in particular, retinoic acid has been shown to inhibit regeneration after partial hepatectomy, most probably through repression of the expression of c-fos and c-jun. Surprisingly enough, in spite of the proposed therapeutic effects of all-trans retinoic acid (tRA) no data are available on its effect on normal adult liver. Here, we show that tRA administration in the diet (150 mg/kg) increased DNA synthesis in mouse liver, at 1 and 2 weeks, with a return to control values at 4 weeks (labelling index was 16.5, 8.3 and 3.3%, respectively, versus control values of 1.4, 1.3 and 2.5%). Increase in mitotic index paralleled that of bromodeoxyuridine incorporation. Kinetic studies showed that entry into S phase began between 24 and 48 h, with a peak between 96 and 120 h. Histological observation of the liver and biochemical evaluation of the levels of serum glutamate-pyruvate transaminases did not reveal any evidence of cell death demonstrating that increased DNA synthesis was not due to tRA-induced liver damage and regeneration, but rather the consequence of a direct mitogenic effect. In addition, analysis of total hepatic DNA content after a 7-day treatment showed a significant increase in tRA-fed mice compared with controls (21.11 mg/100 g body wt in tRA-fed mice versus 15.67 mg/100 g body wt of controls). Hepatocyte proliferation in tRA-fed mice was associated with increased hepatic levels of cyclin D1, E and A, and enhanced expression of the member of pRb family, p107. In conclusion, the results showed that tRA induces hepatocyte proliferation in the absence of cell death, similarly to other ligands of steroid/thyroid hormone nuclear receptor superfamily. The mitogenic effect of tRA cautions about its possible use for antitumoral purposes in liver carcinogenesis.
Role of light and heavy embedded nanoparticles on the thermal conductivity of SiGe alloys (2011)

We have used an atomistic ab initio approach with no adjustable parameters to compute the lattice thermal conductivity of Si${}_{0.5}$Ge${}_{0.5}$ with a low concentration of embedded Si or Ge nanoparticles of diameters up to 4.4 nm. Through exact Green's function calculation of the nanoparticle scattering rates, we find that embedding Ge nanoparticles in ${\text{Si}}_{0.5}{\text{Ge}}_{0.5}$ provides 20% lower thermal conductivities than embedding Si nanoparticles. This contrasts with the Born approximation, which predicts an equal amount of reduction for the two cases, irrespective of the sign of the mass difference. Despite these differences, we find that the Born approximation still performs remarkably well, and it permits investigation of larger nanoparticle sizes, up to 60 nm in diameter, not feasible with the exact approach.
Effect of a ground plane perforation on far-field phase (2002)

A unit cell comprised of a circular aperture is modelled centered in the ground plane beneath a microstrip patch. A phase change of 82–86° is obtained at the patch resonant frequency in the far-field for a cell radius of 0.4L, where L is the resonant length of the patch. A stacked patch structure is investigated to maintain an adequate match at the resonant frequency of the unloaded patch. A phase change of 127° is reported with the stacked patch for a cell radius of 0.2L.
Scalability of Mobile Ad Hoc Networks: Theory vs practice (2010)

Over the past decade, the theoretical or asymptotic scalability of Mobile Ad Hoc Networks (MANETs) has been extensively studied. However, the implication of these asymptotic results on finite, brigade-sized networks with real-life assumptions is not well-understood. We present a two-pronged study on the scalability of military networks with assumptions and goals pertinent to such networks: 1) we investigate the traffic distribution characteristics in a typical military network and show that it follows a power law which exhibits very good scaling properties; 2) we introduce the notion of “in practice” scalability and derive an expression for the in-practice scalability of a simple example network. Our study indicates that MANETs may well be adequately scalable in practice even if they are asymptotically unscalable, and that military MANETs may also even be asymptotically scalable by virtue of their traffic characteristics.
Patch Time Allocation and Search Intensity of Asobara Tabida Nees (Braconidea), a Larval Parasitoid of Drosophila (1980)

We studied three factors affecting the allocation of patch time and the intensity of searching by the larval parasitoid Asobara tabida Nees. We found that: 1. A. tabida reacts to a water-soluble kairomone, produced by its host Drosophila melanogaster Meigen in that a) time spent on a patch (yeast patch in which D. melanogaster larvae had crawled and fed) increased in a S-shaped fashion with increasing kairomone concentration. b) the searching intensity by the parasitoid increased with increasing kairomone concentration until it levels off at higher concentrations. 2. A. tabida recognized areas previously searched by a conspecific and spent less time and searched less intensely on such patches as compared to unsearched patches. 3. Patches with a reduced quality (reduced amount of living yeast) for the host are less attractive for the parasitoid which spends less time and searches less intensely on such patches than on patches with a better quality for the host. The response of the parasitoid to these three factors contributes to the optimization of time allocation.
The Digital signal processing handbook (1998)

From the Publisher:
The field of digital signal processing (DSP) has spurreddevelopments from basic theory of discrete-time signals and processing tools to diverse applications in telecommunications, speech and acoustics, radar, and video. This volume provides an accessible reference, offering theoretical and practical information to the audience of DSP users.
This immense compilation outlines both introductory and specialized aspects of information-bearing signals in digital form, creating a resource relevant to the expanding needs of the engineering community. It also explores the use of computers and special-purpose digital hardware in extracting information or transforming signals in advantageous ways.
Impacted areas presented include: Telecommunications Computer engineering Acoustics Seismic data analysis DSP software and hardware Image and video processing Remote sensing Multimedia applications Medical technology Radar and sonar applications This authoritative collaboration, written by the foremost researchers and practitioners in their fields, comprehensively presents the range of DSP: from theory to application, from algorithms to hardware.
Godzilla: Seamless 2D and 3D Sketch Environment for Reflective and Creative Design Work. (2003)

Understanding how the constitutional dynamics of a dynamic combinatorial library (DCL) adapts to surfaces (compared to bulk solution) is of fundamental importance to the design of adaptive materials. Submolecular resolved scanning tunneling microscopy (STM) can provide detailed insights into olefin metathesis at the interface. Analysis of the distribution of products has revealed the important role of environmental pressure, reaction temperature, and substituent effects in surface-confined olefin metathesis. We also report an unprecedented preferred deposition and assembly of linear polymers, and some specific oligomers, on the surface that are hard to obtain otherwise.
The metabolism of cyclohexanol by Nocardia globerula CL1 (1971)

1. Nocardia globerula CL1, isolated by enrichment on cyclohexanol and grown with it as carbon source, oxidized it with a Q(o2) of 39mul/h per mg dry wt. and the overall consumption of 2.2mumol of oxygen/mol of substrate. Cyclohexanone, 2-hydroxycyclohexan-1-one dimer and cyclohexane-1,2-dione were oxidized with Q(o2) values similar to that for cyclohexanol whereas in-caprolactone and 6-hydroxycaproate were oxidized very slowly and adipate not all. 2. Disrupted cell suspensions could not be shown to catalyse the conversion of cyclohexanol into cyclohexanone. 3. A cyclohexanol-induced cyclohexanone oxygenase (specific activity 0.55mumol of NADPH oxidized/min per mg of protein) catalysed the consumption of 1mol of NADPH and 1mol of O(2) in the presence of 1mol of cyclohexanone. NADPH oxidation did not occur under anaerobic conditions. The only detected reaction product with 25000g supernatant was 6-hydroxycaproate. 4. Extracts of cyclohexanol-grown cells contained a lactone hydrolase (specific activity 15.6mumol hydrolysed/min per mg of protein), which converted in-caprolactone into 6-hydroxycaproate. 5. Incubation of 6-hydroxycaproate with 25000g supernatant in the presence of NAD(+) resulted in NAD(+) reduction under anaerobic conditions, oxygen consumption under aerobic conditions and the conversion of 6-hydroxycaproate into adipate. 6. Cyclohexanone oxygenase fractions devoid of in-caprolactone hydrolase catalysed the stoicheiometric formation of in-caprolactone from cyclohexanone in the presence of excess of NADPH. 7. The reaction sequence for the oxidation of cyclohexanone by N. globerula CL1 is: cyclohexanol --> cyclohexanone --> in-caprolactone --> 6-hydroxycaproate --> adipate. 8. It is suggested that the adipate may be further dissimilated by beta-oxidation.
Incorporation of rubidium cations into perovskite solar cells improves photovoltaic performance (2016)

All of the cations currently used in perovskite solar cells abide by the tolerance factor for incorporation into the lattice. We show that the small and oxidation-stable rubidium cation (Rb<sup>+</sup>) can be embedded into a "cation cascade" to create perovskite materials with excellent material properties. We achieved stabilized efficiencies of up to 21.6% (average value, 20.2%) on small areas (and a stabilized 19.0% on a cell 0.5 square centimeters in area) as well as an electroluminescence of 3.8%. The open-circuit voltage of 1.24 volts at a band gap of 1.63 electron volts leads to a loss in potential of 0.39 volts, versus 0.4 volts for commercial silicon cells. Polymer-coated cells maintained 95% of their initial performance at 85°C for 500 hours under full illumination and maximum power point tracking.
Deep Convolutional Neural Networks Enabled Fingerprint Localization for Massive MIMO-OFDM System (2019)

Fingerprint technique is a promising enabler for mobile terminals (MTs) localization in rich scattering environments, such as urban areas and indoor corridors. In this paper, we investigate fingerprint-based localization for massive multiple- input multiple-output (MIMO) orthogonal frequency- division multiplexing (OFDM) systems with deep convolutional neural networks (DCNNs). By taking full advantage of the high resolution in the angle domain and the delay domain in massive MIMO-OFDM systems, we first propose an efficient angle-delay channel amplitude matrix (ADCAM) fingerprint extraction method. Then a DCNN enabled localization method is proposed, in which the modeling error for fingerprint similarity calculation can be overcome. Both DCNN classification and DCNN regression are considered. For practical implementation, a hierarchical DCNN architecture is proposed. Numerical simulation results demonstrate that DCNN performs well in achieving high localization accuracy as well as reducing storage overhead and computational complexity.
Supply and consumption of glucose 6-phosphate in the chloroplast stroma (2018)

Abstract Fructose 6-phosphate is an intermediate in the Calvin-Benson cycle and can be acted on by phosphoglucoisomerase to make glucose 6-phosphate (G6P) for starch synthesis. A high concentration of G6P is favorable for starch synthesis but can also stimulate G6P dehydrogenase initiating the glucose-6-phosphate shunt an alternative pathway around the Calvin-Benson cycle. A low concentration of glucose 6-phosphate will limit this futile cycle. In order to understand the biochemical regulation of plastidic glucose 6-phosphate supply and consumption, we characterized biochemical parameters of two key enzymes, phosphoglucoisomerase (PGI) and G6P dehydrogenase (G6PDH). We have found that the plastidic PGI in has a higher K m for G6P compared to that for fructose 6-phosphate. The K m of G6PDH isoform 1 is increased under reducing conditions. The other two isoforms exhibit less redox regulation; isoform 2 is the most inhibited by NADPH. Our results support the conclusion that PGI restricts stromal G6P synthesis limiting futile cycling via G6PDH. It also acts like a one-way valve, allowing carbon to leave the Calvin-Benson cycle but not reenter. We found flexible redox regulation of G6PDH that could regulate the glucose-6-phosphate shunt. Highlight Glucose 6-phosphate stimulates glucose-6-phosphate dehydrogenase. This enzyme is less active during the day but retains significant activity that is very sensitive to the concentration of glucose 6-phopshate.
Association of HLA–DR3 with anti–cyclic citrullinated peptide antibody–negative rheumatoid arthritis (2005)

HLA-DR3 is associated with anti-CCP-negative arthritis and not with anti-CCP-positive arthritis. These data show that distinct genetic risk factors are associated with the presence of anti-CCP antibodies in RA and indicate that different pathogenetic mechanisms underlie anti-CCP-positive and anti-CCP-negative RA.
Allosteric Activation of the Follicle-stimulating Hormone (FSH) Receptor by Selective, Nonpeptide Agonists (2006)

The pituitary glycoprotein hormones, luteinizing hormone and follicle-stimulating hormone (FSH), act through their cognate receptors to initiate a series of coordinated physiological events that results in germ cell maturation. Given the importance of FSH in regulating folliculogenesis and fertility, the development of FSH mimetics has been sought to treat infertility. Currently, purified and recombinant human FSH are the only FSH receptor (FSH-R) agonists available for infertility treatment. By screening unbiased combinatorial chemistry libraries, using a cAMP-responsive luciferase reporter assay, we discovered thiazolidinone agonists (EC50's = 20 microm) of the human FSH-R. Subsequent analog library screening and parallel synthesis optimization resulted in the identification of a potent agonist (EC50 = 2 nm) with full efficacy compared with FSH that was FSH-R-selective and -dependent. The compound mediated progesterone production in Y1 cells transfected with the human FSH-R (EC50 = 980 nm) and estradiol production from primary rat ovarian granulosa cells (EC50 = 10.5 nm). This and related compounds did not compete with FSH for binding to the FSH-R. Use of human FSH/thyroid-stimulating hormone (TSH) receptor chimeras suggested a novel mechanism for receptor activation through a binding site independent of the natural hormone binding site. This study is the first report of a high affinity small molecule agonist that activates a glycoprotein hormone receptor through an allosteric mechanism. The small molecule FSH receptor agonists described here could lead to an oral alternative to the current parenteral FSH treatments used clinically to induce ovarian stimulation for both in vivo and in vitro fertilization therapy.
MicroRNA-568 inhibit CD4+ T cell activation through targeting NFAT5 (176.2) (2012)

Abstract MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression posttranscriptionally and are also known to be involved in lymphocyte development and function. In our previous study, by using microRNA array, we tried to identify the miRNAs that may regulate T cell activation, and we have reported that miR-181c can regulate T cell activation through directly targeting IL-2 (Mol Immunol, 2011, 48: 592-599). Here we reported that during CD4+ T cell activation, the expression of miR-568 was decreased. Forced expression of miR-568 can significantly inhibit the activation of Jurkat cells and human peripheral CD4+ T cells after stimulation. NFAT5 was predicted to be a potential target of miR-568, and the expression of NFAT5 was increased during CD4+ T cell activation. NFAT5 3’UTR luciferase reporter assay showed that miR-568 can inhibit the expression of luciferase, but can’t inhibit the mutated NFAT5 3’UTR luciferase reporter expression. Upregulation of miR-568 can inhibit the expression of NFAT5 in CD4+ T cells, while miR-568 inhibitors can increase the NFAT5 level. Furthermore, we found that knockdown of NFAT5 can inhibit the activation of CD4+ T cells after stimulation. Thus, our results demonstrated that microRNA-568 can inhibit CD4 T cell activation, at least in part, through targeting NFAT5.
Structure of the toxisterols2: X-ray crystal structure of toxisterol2-D epoxide (1976)

A. G. M. Barrett, D. H. R. Barton, R. A. Russell, P. F. Lindley and M. M. Mahmoud, J. Chem. Soc., Chem. Commun., 1976, 659 DOI: 10.1039/C39760000659
Towards Immersive Learning in Object-Oriented Paradigm: A Preliminary Study (2019)

Object-Oriented Paradigm Teaching is mandatory in the curriculum of the courses of the Computing area. Students are taught fundamental concepts about this paradigm, such as class, object, encapsulation, polymorphism, generalization and composition. One of the major challenges of Software Engineering is to teach complex and abstract concepts in a short time, with examples or simple projects done in academic environments. Virtual Reality has demonstrated advantages applied to Education, providing immersive experiences and new ways of visualization and interaction. However, this technology has not been extensively explored in Software Engineering. In this sense, this paper aims to present a disruptive method of teaching and learning support on fundamentals in object orientation paradigm based on Immersive Learning, called OO Game VR. In addition, an initial heuristic evaluation was performed with 6 subjects in order to identify usability problems. Despite problems found related to support learning, navigation and orientation, the natural expression of action and clear entry and exit points, the subjects were able to perform all the tasks, showing indications that the application has the potential to support teaching of OOP teaching through Immersive Learning. In future works, the usability problems will be fixed and specific methods will be applied for measuring influence immersion on learning outcomes.
New data about the reaction of benzyolacetonitrile with malononitrile and its self‐condensation (2006)

Abstract magnified image The reactions of benzoylacetonitrile with malononitrile in refluxing pyridine and its self condensation under fusion conditions in the presence of ammonium acetate and in refluxing pyridine were reinvestigated. New data were found and plausible mechanisms to account for the formation of the products are suggested.
Endovascular repair of the ruptured abdominal aortic aneurysm (2008)

International audience
Antiangiogenic Effectiveness of the Urokinase Receptor-Derived Peptide UPARANT in a Model of Oxygen-Induced Retinopathy (2015)

The finding that UPARANT is effective against neovascularization may help to establish uPAR as a target in the treatment of proliferative retinopathies. The potential application of UPARANT in retinal diseases is further supported by UPARANT capacity to counteract the angiogenic activity of PDR vitreous fluid.
Structure and In Vivo Behavior of Human Fibrinogen Fragment-D (1972)

Polyacrylamide gel disc electrophoresis has been used to determine molecular weights of fg-D and its three subunits. A molecular weight of 78,800 ± 3900 was determined for fg-D. Three subunits, apparently representing individual polypeptide chains with molecular weights of 44,000 ± 2700; 25,350 ± 900; and 10,400 ± 720 have been demonstrated. The sum of the molecular weights of these polypeptide chains agrees closely with the estimated size of the intact fg-D fragment. We have confirmed micro-heterogeneity of fg-D on disc acrylamide gel electrophoresis and have demonstrated that this heterogeneity is a reflection of charge isomerization and does not represent detectable differences in size. In vivo studies demonstrated that fg-D does not interact with plasma proteins but circulates in a free state. It is cleared rapidly from plasma with a half-life of 2 hr ± 12 min, and excreted in urine following catabolic degradation.
The Di-t-Butylphosphinyl Directed ortho Metalation Group. Synthesis of Hindered Dialkylarylphosphines (1998)

Using the new P(O) t Bu2 Directed Metalation Group, a variety of ortho-substituted aryl di-t-butylphenylphosphine oxides (2a-k) have been prepared, its relative metalation ability has been established, and reduction and homocoupling products (Scheme 4) have been obtained.
Calibração de um Arranjo Linear de Antenas para Estimação de Direção de Chegada (2004)

A no linearidade geomtrica de um arranjo de antenas um dos graves problemas a boa deteco da direo de chegada (DoA) de sinais RF quando essa arbitrariedade no conhecida pelo estimador de DoA em banda-base. Apresenta-se neste artigo um mtodo de calibrao do posicionamento dos elementos
Más allá de los 10GHz: la nueva frontera del Osciloscopio (2005)

Several human postnatal somatic cell types have been successfully reprogrammed to induced pluripotent stem cells (iPSCs). Blood mononuclear cells (MNCs) offer several advantages compared with other cell types. They are easily isolated from umbilical cord blood (CB) or adult peripheral blood (PB), and can be used fresh or after freezing. A short culture allows for more efficient reprogramming, with iPSC colonies forming from blood MNCs in 14 d, compared with 28 d for age-matched fibroblastic cells. The advantages of briefly cultured blood MNCs may be due to favorable epigenetic profiles and gene expression patterns. Blood cells from adults, especially nonlymphoid cells that are replenished frequently from intermittently activated blood stem cells, are short-lived in vivo and may contain less somatic mutations than skin fibroblasts, which are more exposed to environmental mutagens over time. We describe here a detailed, validated protocol for effective generation of integration-free human iPSCs from blood MNCs by plasmid vectors.
Practical Implementation of Integer Forcing Linear Receivers in MIMO Channels (2013)

Integer Forcing (IF) architecture has been recently proposed to design linear receivers in MIMO systems. Research works show the promise of this architecture from a capacity achieving perspective. However, it is not totally understood how to select IF coefficient matrix and if the promised theoretical gain of the resulting receivers is attainable in practical settings. We try in this work to fill the gap between theory and practice: we propose algorithms to select optimal IF receiver parameters that lead to the maximization of the total achievable rate. We propose an implementation of an IF-based MIMO system considering a practical scenario where lattice codes are used. Experimental studies are carried out to evaluate the error rate performance of the proposed algorithms and compare them to traditional linear receivers. Our proposed implementation shows that the theoretical potential of the IF receivers is achievable even with finite-length lattice codes.