gebhart/patrepeval huggingface dataset:
Vancomycin skin tests and prediction of "red man syndrome" in healthy volunteers (1993)

The purpose of the present study was to assess the cutaneous response to intradermally administered vancomycin in healthy adults and to determine whether the magnitude of the cutaneous response correlated to the severity of "red man syndrome" (RMS) following intravenous administration of vancomycin to the same subjects. Eleven healthy males were skin tested with intradermally administered histamine and saline controls and intradermally administered vancomycin at different concentrations. Vancomycin caused a dose-dependent area of flare in all subjects. The sigmoidal maximal flare model was used to fit each dose-response curve, and cutaneous responsiveness to vancomycin was quantified by various methods, including the flare area at each dose, maximum flare area (maximal flare), dose required to produce 50% of maximum flare, dose required to produce a flare area of 400 mm2, and the slope of the dose-response curve. One week after skin testing, subjects received an infusion of vancomycin, 15 mg/kg of body weight over 60 min. For the assessment of the severity of RMS, we used previously described methods. Although all subjects experienced erythema from the intravenously administered vancomycin and 10 subjects had pruritus, there was no significant correlation between vancomycin skin test results and the severity of RMS. We conclude that vancomycin skin tests do not predict the severity of RMS. In addition, vancomycin skin tests may be of no benefit for assessing immunoglobulin E-mediated allergy to vancomycin, since all subjects had a positive reaction at concentrations of > or = 10 micrograms/ml.
Suspension‐deposited carbon‐nanotube networks for flexible active‐matrix displays (2008)

Abstract— The unique properties of carbon nanotubes (CNTs) promise innovative solutions for a variety of display applications. The CNTs can be deposited from suspension. These simple and low‐cost techniques will replace time‐consuming and costly vacuum processes and can be applied to large‐area glass and flexible substrates. Single‐walled carbon nanotubes (SWNTs) have been used as conducting and transparent layers, replacing the brittle ITO, and as the semiconducting layer in thin‐film transistors (TFTs). There is no need for alignment because a CNT network is used instead of single CNTs. Both processes can be applied to glass and to flexible plastic substrates. The transparent and conductive nanotube layers can be produced with a sheet resistance of 400 Ω/□ at 80% transmittance. Such layers have been used to produce directly addressed liquid‐crystal displays and organic light‐emitting diodes (OLED). The CNT‐TFTs reach on/off ratios of more than 10 5 and effective charge‐carrier mobilities of 1 cm 2 /V‐sec and above.
Abstract 2698: Improved therapeutic activity of Isoflavone-G2535 and Docetaxel combination in hormone refractory prostate cancer (2012)

Abstract The emergence of Castrate Resistant Prostate Cancer (CRPC) and its subsequent metastasis to the bone is in part driven by Androgen Receptor (AR) signaling, and contributes to overall poor survival of prostate cancer patients. Here, we present in vitro and in vivo preclinical evidence of chemo-sensitization of CRPC cells to the most clinically useful therapeutic agent, Docetaxel (Taxotere) by G2535, an isoflavone that attenuates AR signaling. In vitro studies were done using AR+ prostate cancer (PCa) cell lines (LNCaP and C4-2B) to understand the molecular basis of combination therapy. We found that the combination was significantly more effective in inhibiting cell growth and induction of apoptosis (p&amp;lt;0.01), down-regulation of AR and its target, prostate specific antigen (PSA) (p&amp;lt;0.01) with suboptimal concentrations of Docetaxel (1nmole/L) compared to monotherapy. It is known that resistance to chemotherapy in CRPC is partly associated with constitutively activated NF-κB/Akt signaling pathways, which becomes further activated by chemotherapeutic drugs, and these molecular targets were found to be down-regulated by G2535 treatment. Of greater significance were the results from in vivo tumor growth inhibition studies conducted in a SCID-hu model of experimental bone metastasis induced by C4-2B cells. Tumor volume, AR and serum PSA was used as response markers to evaluate therapeutic activity of the combination therapy relative to a single regimen and untreated control. At termination, we found 75% reduction in tumor volume elicited by the combination treatment relative to the untreated control group. Most importantly, the anti-tumor activity was associated with the down-regulation of molecular markers in tumor tissue remnants that were similar to those observed in vitro (down regulation of NF-κB, Bcl-2 and survivin) accompanied by a significant reduction in serum PSA. Using qPCR, we found that the level of miR-34a, which target AR, was increased by 1.5 fold after G2535 treatment alone whereas this increase was found to be 3-fold in the combination group. Increased expression of miR-34a resulted in the down regulation of AR and PSA in this in vivo model. Based on our findings, we conclude that the combination of G2535 and Taxotere could be an alternative promising regimen for the treatment of CRPC and its metastases for which curative treatment is urgently needed. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2698. doi:1538-7445.AM2012-2698
Cohesive zone models and the plastically deforming peel test (2003)

The peel test is a popular test method for measuring the peeling energy between flexible laminates. However, when plastic deformation occurs in the peel arm(s) the determination of the true adhesive fracture energy, G c , from the measured peel load is far from straightforward. Two different methods of approaching this problem have been reported in recently published papers, namely: (a) a simple linear-elastic stiffness approach, and (b) a critical, limiting maximum stress, σ max , approach. In the present article, these approaches will be explored and contrasted. Our aims include trying to identify the physical meaning, if any, of the parameter σ max and deciding which is the better approach for defining fracture when suitable definitive experiments are undertaken. Cohesive zone models Fracture mechanics Laminates Peel tests Plastic deformation
A Framework for QoS-aware Traffic Classification Using Semi-supervised Machine Learning in SDNs (2016)

In this paper, a QoS-aware traffic classification framework for software defined networks is proposed. Instead of identifying specific applications in most of the previous work of traffic classification, our approach classifies the network traffic into different classes according to the QoS requirements, which provide the crucial information to enable the fine-grained and QoS-aware traffic engineering. The proposed framework is fully located in the network controller so that the real-time, adaptive, and accurate traffic classification can be realized by exploiting the superior computation capacity, the global visibility, andthe inherent programmability of the network controller. More specifically, the proposed framework jointly exploits deep packet inspection (DPI) and semi-supervised machine learning so that accurate traffic classification can be realized, while requiring minimal communications between the network controller and the SDN switches. Based on the real Internet data set, the simulation results show the proposed classification framework can provide good performance in terms of classification accuracy and communication costs
Electron microscopy of oxyborates. I. Defect structures in the minerals pinakiolite, ludwigite, orthopinakiolite and takéuchiite (1981)

Crystals of the minerals pinakiolite (Mg,Mn)1.77-(Mn,Al,Fe)1.11BO5, ludwigite (Mg,Fe)2Fe3+BO5, orthopinakiolite (Mg,Mn)1.85(Mn3+,Fe3+)BO5 and takéuchiite (Mg,Mn)1.97Mn3+0.78Fe3+0.19BO5 have been investigated by high-resolution transmission electron microscopy. Calculated and experimental images have been matched to ensure a proper interpretation. All the minerals except ludwigite show structural defects which give insight into structural relations in the pinakiolite family. It is shown that they can be described as chemical twinnings of pinakiolite. The most common defects can be described as missing twin operations.
Super-stereotypy I: Enhancement of a complex movement sequence by systemic dopamine D1 agonists (2000)

Peripheral administration of D1 dopamine agonists elicits grooming behavior from rodents. The present study examined grooming behavior and the relative probability and stereotypy of a natural sequence of grooming movements (called a syntactic grooming chain) that follows a predictable fixed pattern of serial order. We compared the amount of grooming behavior vs. the stereotypy of sequential patterns after peripheral administration of either a partial D1 agonist (SKF 38393; 2.5, 5.0, 10, 20 mg/kg), a full D1 agonist (SKF 82958; 0.1, 0.2, 0.5, 1.0 mg/kg; i.p.), a D2 agonist (quinpirole; 5.0, 10 mg/kg), or ACTH (2.0, 5.0 mg/kg). There was a dissociation between the elicited grooming amount, the pattern frequency, and the pattern completion or sequential stereotypy after these drugs. Quinpirole and ACTH both reduced the likelihood that the sequential pattern would be completed in the normal pattern (and reduced the overall amount of grooming). Administration of either SKF 38393 or SKF 82958 increased the tendency to engage in complex stereotyped sequential patterns of grooming (even though only the partial D1 agonist increased the total amount of grooming). In addition, SKF 38393 increased the sequential stereotypy of the already-stereotyped pattern itself (as measured by the probability of completing the stereotyped sequence once it began). Thus, dopamine D1 receptor activation appears to contribute to a kind of sequential super-stereotypy in which a complex, stereotyped behavioral sequence is initiated more frequently and more often goes to completion.
The use of orbital angular momentum of light beams for optical data storage (2004)

We present a method to optically store multiple information in one location by having angular momentum imparted to the scanning beam by the optical effects.
Semantics of Transient Connectors in Rewriting Logic (1998)

Research in Software Architectures has put forward the concept of connector to express complex relationships between system components, thus facilitating the separation of coordination from computation. A system can then be understood, at a given level of abstraction, in terms of its components and the connectors that establish how they interact. However, for systems in which many interconnections exist between their components, the architectures themselves may become very complex due to the high number of connectors in place. This is especially true in the context of mobile systems in which the interconnections are, by nature, transient in the sense that, at a given instant of time, only a subset of the potential connectors are actually effective. In this paper, we formalise a notion of transient connector that allows, at any given moment, for the architecture to depict only the connectors that are active and, in this way, capture the dynamics of architectures themselves. Our approach is based on the use of Community, a Unity-like program design language that has a semantics in Category Theory, and rewriting logic as a means of capturing the dynamic aspects of connectors
Combined obstructive airflow limitation associated with interstitial lung diseases (O-ILD): the bad phenotype ? (2022)

The authors individualized a specific functional-based pattern of ILD patients with obstructive lung disease, who are at risk of increased mortality and rapid DLCO decline over time. As classically those patients are excluded from clinical trials, a dedicated prospective study would be of interest in order to define more precisely treatment response of those patients.
A general-purpose link interface chipset for gigabit rate data communication (2003)

A chipset has been developed for transmitting parallel data over serial links. The chipset, consisting of a transmitter interface chip (TIC) and a receiver interface chip (RIC), can support serial transmission up to 1.4 Gbaud. Data encoding is based on a scheme published earlier, but has been improved to provide more flexibility and better efficiency. The chipset requires no external components for its operation other than a few capacitors, which are built into its custom package.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Rapid and convenient conversion of nitroarenes to anilines under microwave conditions using nonprecious metals in mildly acidic medium (2017)

Nitroarenes are reduced to the corresponding aniline derivatives using iron or zinc under mild conditions under microwave heating conditions. Mild acidity is provided by ammonium chloride in an aqueous methanol medium. The conditions are tolerant to other functional groups, with the exception of bromoalkyl derivatives, which yield complex reaction mixtures; otherwise, yields are generally quite high (80–99%).
Online Quality Assurance of Microchannels in Roll-to-Roll by Optical Coherence Tomography (2020)

Roll-to-roll (R2R) process is an emerging technology to manufacture printed electronics, microfluidics, biochemical sensors etc. The requirements for high quality and small tolerances at the manufacturing phase are of the essence for such products. To verify the quality and guarantee the high production yield, high speed, non-destructive testing methods are needed. In this paper, optical coherence tomography (OCT) device is used at the R2R-line to measure online hot embossed microchannel structures at speed of 1 m/min, which is typical for the hot embossing process. The channel’s width and shape are determined along the web. The applicability of OCT for topography measurements is demonstrated in an actual R2R environment.
Annexe Nº 2. Extraits du code pénal péruvien (2011)

Article 60 : « El tratamiento penitenciario tiene como objetivo la reeducación, rehabilitación y reincorporación del interno a la sociedad. » Assistance médicale Article 80 : « El interno puede solicitar, asumiendo su costo, los servicios médicos de profesionales ajenos al Establecimiento Penitenciario. » Article 82 : « El interno que requiere atención médica especializada fuera del Establecimiento Penitenciario la solicita al Consejo Técnico Penitenciario, el que dispondrá que una junta médi...
A630. LONG-TERM RESULTS OF CEMENTED PRIMARY TOTAL HIP ARTHROPLASTY FOR DYSPLASIA, WITH STRUCTURAL AUTOGRAFT FIXED WITH PLLA SCREWS (2011)

Poly-L-lactic acid (PLLA) is characterized by its biocompatibility and biodegradability, and is used clinically. In our hospital, we started to use PLLA screws instead of metallic or ceramic screws in the fixation of acetabular bone grafts in total hip arthroplasty (THA) in 1990, because there were concerns about the use of rigid and nonbioabsorble screws, which might contribute to the absorption of the grafted bone and induce metallosis or third-body wear when breakage of the screws occurs. The purpose of this study was to review a series of cemented THA for dysplasia, with structural autograft fixed with PLLA screws. We focused on the survival rate of the acetabular component and radiological change of the grafted bone–socket interface. This study included 104 consecutive cemented total hip arthroplasties (80 patients) performed between July 1990 and December 1995 in our hospital. All patients were followed over 10 years and reviewed retrospectively. The grafted bone trimmed from the excised femoral head was fixed rigidly with 1 or 2 PLLA screws (cancellous lag screws 6.5 mm in bore diameter and 4.1 mm in grove diameter) (Fixsorb; Takiron Co., Ltd., Osaka, Japan). X-ray photographs taken just after the primary operation showed an obscure but still visible radiolu-cent region corresponding to the inserted PLLA screws in many cases. However, X-ray photographs at the final follow-up showed an unclear radiolucent zone at the sites of the PLLA screws, and the osteosclerotic line surrounding the site where the radiolucent zone had been found was confirmed in only 4 cases. Bone union was confirmed radiologically at the grafted site in every case, and there were no cases of early collapse or extravasation of the grafted bone. No positive resorption of the grafted bone was observed in any case. Kaplan–Meier survivorship analysis of socket revision, radiological loosening of the socket, and the appearance of a radiolucent line > 1 mm in the graft–socket interface as the endpoints indicated survival rates of 99%, 97.1%, and 63.5% at 10 years, and 96.6%, 90.2%, and 56.1% at 15 years, respectively. The results of this study indicated that PLLA screws are safe and useful for the fixation of acetabular bone graft concomitant to cemented THA with a careful rehabilitation program. However, because of concern about the mechanical insufficiency of the PLLA screws for THA with an early weight-bearing rehabilitation program, we have used mechanically stronger and bioabsorbable screws made of forged composites of hydroxyapatite and PLLA since 2003.
A frame erasure concealment method based on pitch and gain linear prediction for AMR-WB codec (2011)

This paper presents a novel error concealment method for AMR-WB codec, using excitation search constraint at the encoder and a linear prediction of the pitch and gains of the adaptive codebook and the innovative codebook at the decoder to enhance speech quality after a frame erasure. The experimental results demonstrate that the proposed method achieves performance improvement over the existing methods.
Central Sensitivity Is Associated with Poor Recovery of Pain: Prediction, Cluster, and Decision Tree Analyses (2020)

The process of pain recovery varies and can include the recovery, maintenance, or worsening of symptoms. Many cases of patients with pain show a tendency of recovering as predicted; however, some do not. The characteristics of cases that do not fit the prediction of pain recovery remain unclear. We performed cluster and decision tree analyses to reveal the characteristics in cases that do not fit the prediction of pain recovery. A total of 43 patients with musculoskeletal pain (nonoperative: 22 patients, operative: 13 patients) and central pain (brain disease: 5 patients, spinal cord disease: 3 patients) were included in this longitudinal study. Central sensitivity syndrome (CSS) outcome measures (Central Sensitisation Inventory), pain intensity-related outcome measures (Short-Form McGill Pain Questionnaire-2 (SFMPQ-2)), and cognitive-emotional outcome measures (Hospital Anxiety and Depression Scale and Pain Catastrophising Scale-4) of all patients were assessed at baseline and after 1-2 months. Regression analysis was used to calculate pain recovery prediction values. A hierarchical cluster analysis based on the predicted change of SFMPQ-2 and the observed change of SFMPQ-2 was used to extract subgroups that fit and those that do not fit pain recovery prediction. To extract the characteristics of subgroups that do not fit the prediction of pain recovery, a decision tree analysis was performed. The level of significance was set at 5%. In the results of cluster analysis, patients were classified into three subgroups. Cluster 1 was characterised by worse pain intensity from baseline, cluster 2 by pain, having recovered less and mildly than the predicted value, and Cluster 3 by a marked recovery of pain. In the results of the decision tree analysis, the CSI change was extracted as an indicator related to the classification of all clusters. Our findings suggest that the poor improvement of CSS is characteristic in cases that do not fit the prediction of pain recovery.
WindPACT Turbine Design Scaling Studies Technical Area 2: Turbine, Rotor and Blade Logistics (2001)

Through the National Renewable Energy Laboratory (NREL), the United States Department of Energy (DOE) implemented the Wind Partnership for Advanced Component Technologies (WindPACT) program. This program will explore advanced technologies that may reduce the cost of energy (COE) from wind turbines. The initial step in the WindPACT program is a series of preliminary scaling studies intended to determine the optimum sizes for future turbines, help define sizing limits for certain critical technologies, and explore the potential for advanced technologies to contribute to reduced COE as turbine scales increase. This report documents the results of Technical Area 2-Turbine Rotor and Blade Logistics. For this report, we investigated the transportation, assembly, and crane logistics and costs associated with installation of a range of multi-megawatt-scale wind turbines. We focused on using currently available equipment, assembly techniques, and transportation system capabilities and limitations to hypothetically transport and install 50 wind turbines at a facility in south-central South Dakota.
Comparison of the effects of propranolol, pindolol, oxprenolol and acebutolol on atrioventricular conduction in unanaesthetized dogs. (1982)

1 Atrio-ventricular conduction (AVC) in the unanaesthetized dog (17 animals) was studied using atrial pacing at progressively increasing frequencies applied via electrodes implanted in the right atrium. In animals habituated to the experimental conditions, beta-adrenoceptor blocking drugs devoid of intrinsic sympathomimetic activity (ISA) modified neither heart-rate (HR) nor AVC, though 4 mg/kg i.v. propranolol transiently raised HR and facilitated AVC. Due to their ISA, pindolol and oxprenolol raised HR and facilitated AVC at high doses. 2 Thus, when not under anaesthesia, the resting dog, in contrast to man, possesses no tonic adrenergic influence which might be suppressed by beta-adrenoceptor blockings drugs. 3 After atropine or pentobarbitone, which considerably increased HR, beta-adrenoceptor blocking effects became clearly visible, and the hitherto reported depressant effects on HR and AVC were observed. However, the ISA of oxprenolol, and especially of pindolol, can partly or completely mask their beta-adrenoceptor blocking action at high doses under these experimental conditions.
Synthesis of Aminofuroxan Derivatives for the Alkyne Formation on Solid Surface and e-Beam Mediated Fragmentation in Gas Phase (2007)

고체상 표면에서 퓨록산 화합물의 박막생성을 위하여 클로로퓨록산 2와 butyl 및 benzyl amine과 반응시킨 아미노퓨록산 3,4를 합성하고 이들 아미노퓨록산 화합물을 질량분석기에서 전자빔에 의한 분해반응을 분석하여 알카인의 생성에 대한 효율성을 살펴보았다. Aminofuroxan derivatives 3 and 4 were prepared by the reaction of chlorofuroxan 2 with butyl and benzyl amines, respectively. E-beam mediated fragmentation of aminofuroxans 3, 4 in mass spectrometer was analyzed in a view of the corresponding alkyne formation.
Performance of Double-Groove Grating with +1st-Order Diffraction Angle Larger than Substrate-Air Critical Angle (2011)

We present a technique to couple the normally incident light into the +1st-order transmission with around 97 % efficiency and with a 50° diffraction angle in a TiO2 double-groove grating attached on the SiO2 substrate.
P‐REX2, a novel PI‐3‐kinase sensitive Rac exchange factor (2004)

We have identified an activator of Rac, P-REX2, that is structurally related to the exchange factor PtdIns(3,4,5)-dependent Rac exchanger (P-REX1), but exhibits distinct tissue-specific expression. P-REX2 is spliced into two RNA species, approximately 3.5 and approximately 10 kb in size. The cDNA corresponding to the smaller transcript encodes a protein that exhibits strong similarity with P-REX1 within its N-terminal domains, but differs in the C-terminal region. P-REX2 promoted increased levels of GTP-bound Rac that could be further stimulated by enhancing PI-3K activity. Thus, P-REX2 may serve as a novel link between Rac activation and the PI-3 kinase pathway.