gebhart/patrepeval huggingface dataset:
Decay-Accelerating Factor and Cytoskeleton Redistribution Pattern in HeLa Cells Infected with RecombinantEscherichia coliStrains Expressing Dr Family of Adhesins (1999)

Escherichia coli strains expressing Dr fimbriae are able to enter epithelial cells by interacting with a complement-regulatory protein, decay-accelerating factor. This model of bacterial internalization, with a well-characterized bacterial ligand and host receptor, provides a unique opportunity to investigate the early stages of invasion. We used immunofluorescence staining techniques to examine the distribution of receptor and cytoskeletal proteins in HeLa cells infected with E. coli recombinant strains that expressed Dr family of adhesins: Dr, Dr-II, F1845, AFA-I, and AFA-III. A major rearrangement of decay-accelerating factor was found at the adherence sites of recombinant strains expressing Dr, Dr-II, and F1845 adhesins. The changes in the distribution of receptor were significantly smaller on HeLa cells infected with E. coli bearing AFA-I or AFA-III afimbrial adhesins. Receptor aggregation was associated with the redistribution of cytoskeleton-associated proteins such as actin, alpha-actinin, ezrin, and occasionally tropomyosin. Purified Dr fimbriae coated on polystyrene beads were capable of triggering clustering of receptor and accumulating actin at the adhesion sites of beads to HeLa cells. Using scanning and transmission electron microscopic techniques, we have shown that beads coated with Dr fimbriae, as opposed to beads coated with bovine serum albumin, were enwrapped by cellular microvilli and ultimately internalized into HeLa cells. This indicates that interaction of Dr fimbriae with decay-accelerating factor is associated with redistribution of receptor and is sufficient to promote bacterial internalization.
LIV. Lexikon der indogermanischen Verben. Die Wurzeln und ihre Primärstammbildungen. Unter Leitung von H. Rix und der Mitarbeit vieler anderer bearbeitet von M. Kümmel, Th. Zehnder, R. Lipp, B. Schirmer. Zweite, erweiterte und verbesserte Auflage bearbeit (2004)

LIV. Lexikon der indogermanischen Verben. Die Wurzeln und ihre Primärstammbildungen. Unter Leitung von Helmut Rix und der Mitarbeit vieler anderer bearbeitet von Martin Kümmel, Thomas Zehnder, Reiner Lipp, Brigitte Schirmer. Zweite, erweiterte und verbesserte Auflage bearbeitet von Martin Kümmel und Helmut Rix. Wiesbaden, Dr. Ludwig Reichert Verlag, 2001, gr.-8°, VIII, 823S. Geb. 68EUR.
Colorimetric Detection of Cyanide with a Chromogenic Oxazine (2005)

[reaction: see text] We have designed a chromogenic oxazine for the colorimetric detection of cyanide. Indeed, the [1,3]oxazine ring of our compound opens to form a 4-nitrophenylazophenolate chromophore in response to cyanide. This quantitative chromogenic transformation permits the detection of micromolar concentrations of cyanide in water. Furthermore, our chromogenic oxazine is insensitive to the presence of large concentrations of fluoride, chloride, bromide, or iodide anions, which are generally the principal interferents in the colorimetric detection of cyanide.
A New, Flexible and Very Accurate Crosstalk Fault Model to Analyze the Effects of Coupling Noise between the Interconnects on Signal Integrity Losses in Deep Submicron Chips (2005)

In this paper a new, flexible and a very accurate crosstalk fault model is developed which considers the capacitive coupling noise between the aggressor and the victim interconnect in deep sub-micron chips. The proposed crosstalk model is based on the distributed ABCD model of a long on-chip interconnect and takes into account the CMOS driver and receiver parameters of both aggressor and victim interconnects, besides the consideration of usual distributed per-unit-length RLGC parasitic elements and coupling capacitance, and interconnect’s length. Simulations are all carried out using the Philips CMOS12 (130nm) technology parameters and the model accuracy is found very much close to PSPICE simulation result. The same model can further be utilized to analyze/estimate the influence of interconnect parasitics on various signal integrity losses such as delay, glitch, overshoot, or crosstalk hazards (if any).
Morphogenesis and mechanostabilization of complex natural and 3D printed shapes (2015)

The natural selection and the evolutionary optimization of complex shapes in nature are closely related to their functions. Mechanostabilization of shape of biological structure via morphogenesis has several beautiful examples. With the help of simple mechanics-based modeling and experiments, we show an important causality between natural shape selection as evolutionary outcome and the mechanostabilization of seashells. The effect of biological growth on the mechanostabilization process is identified with examples of two natural shapes of seashells, one having a diametrically converging localization of stresses and the other having a helicoidally concentric localization of stresses. We demonstrate how the evolved shape enables predictable protection of soft body parts of the species. The effect of bioavailability of natural material is found to be a secondary factor compared to shape selectivity, where material microstructure only acts as a constraint to evolutionary optimization. This is confirmed by comparing the mechanostabilization behavior of three-dimensionally printed synthetic polymer structural shapes with that of natural seashells consisting of ceramic and protein. This study also highlights interesting possibilities in achieving a new design of structures made of ordinary materials which have bio-inspired optimization objectives.
Nucleotides, Part LXIX, Synthesis of Phosphoramidite Building Blocks of IsoxanthopterinN8-(2′-Deoxy-β-D-ribonucleosides): New Fluorescence Markers for Oligonucleotide Synthesis (2001)

The chemical synthesis of isoxanthopterin and 6-phenylisoxanthopterin N8-(2′-deoxy-β-D-ribofuranosyl nucleosides) is described as well as their conversion into suitably protected 3′-phosphoramidite building blocks to be used as marker molecules for DNA synthesis. Applying the npe/npeoc (=2-(4-nitrophenyl)ethyl/[2-(4-nitrophenyl)ethoxy]carbonyl) strategy, we used the new building blocks in the preparation of oligonucleotides by an automated solid-support approach. The hybridization properties of a series of labelled oligomers were studied by UV-melting techniques. It was found that the newly synthesized markers only slightly interfered with the abilities of the labelled oligomers to form stable duplexes with complementary oligonucleotides.
Age-Related Eye Disease, Visual Impairment, and Driving in the Elderly (1991)

As people age, a number of visual functions such as acuity, visual field, and night vision deteriorate. This decline in vision is associated in part with an increase in vehicular accidents per mile driven by the elderly. Four age-related ocular conditions--cataract, macular degeneration, open-angle glaucoma, and diabetic retinopathy--are primarily responsible for the decline in visual acuity and visual field in the elderly. Few epidemiologic data are available about these diseases, and at present they cannot be prevented. There is need for more information about visual decline and how it affects driving performance and for development of pragmatic approaches for detecting and assessing the elderly driver with functional visual deficits.
Effects of Increasing Dietary Standardized Ileal Digestible Lysine on 15 to 24 lb Nursery Pigs (2016)

A total of 300 nursery pigs (PIC 327 × 1050, initially 14.8 lb BW) were used in a 28-d growth trial to evaluate the effects of increasing dietary standardized ileal digestible (SID) lysine (Lys) on nursery pig growth performance. Pigs were weaned at approximately 21 d of age and allotted to the pens according to BW and gender. A common starter diet was fed for 6 d, then pens were allotted to 1 of 6 dietary treatments in a completely randomized design. Experimental diets were fed for 14 d followed by a common diet for 14 d. The 6 dietary treatments were formulated to contain 1.10, 1.20, 1.30, 1.40, 1.50, and 1.60% SID Lys.Increasing SID Lys resulted in improved (linear, P < 0.001) ADG and F/G during d 0 to 14 when experimental diets where fed, with no differences observed in ADFI. For ADG, broken line linear (BLL) and quadratic polynomial (QP) models demonstrated similar fits, with maximum ADG at 1.45% and above 1.60% for BLL and QP models, respectively. Similar estimates were found when modeling feed efficiency.In conclusion, this experiment determined that the SID Lys requirement for 15 to 24 lb nursery pigs was at least 1.45% SID Lys for both ADG and feed efficiency.
Data from FKBPL Regulates Estrogen Receptor Signaling and Determines Response to Endocrine Therapy (2023)

&lt;div&gt;Abstract&lt;p&gt;The HSP90 chaperone and immunophilin FKBPL is an estrogen-responsive gene that interacts with estogen receptor α (ERα) and regulates its levels. In this study, we explored the effects of FKBPL on breast cancer proliferation. Breast cancer cells stably overexpressing FKBPL became dependent on estrogen for their growth and were dramatically more sensitive to the antiestrogens tamoxifen and fulvestrant, whereas FKBPL knockdown reverses this phenotype. FKBPL knockdown also decreased the levels of the cell cycle inhibitor p21WAF1 and increased ERα phosphorylation on Ser&lt;sup&gt;118&lt;/sup&gt; in response to 17β-estradiol and tamoxifen. In support of the likelihood that these effects explained FKBPL-mediated cell growth inhibition and sensitivity to endocrine therapies, FKBPL expression was correlated with increased overall survival and distant metastasis-free survival in breast cancer patients. Our findings suggest that FKBPL may have prognostic value based on its impact on tumor proliferative capacity and sensitivity to endocrine therapies, which improve outcome. Cancer Res; 70(3); 1090–100&lt;/p&gt;&lt;/div&gt;
Perspectives on Mussel-Inspired Wet Adhesion (2017)

Nature employs sophisticated control of a structure's properties at multiple length scales to achieve its wet adhesion. However, the translation of such structures has very often been missing in biomimetic adhesives; in turn, their performance is significantly limited as compared to that of biological adhesion, e.g., from mussels. In this Perspective, we overview the major breakthroughs in this field, highlighting the recent advances that demonstrate that holistic multiscale translation is essential to biomimetic design. We argue that the multiscale coordination of numerous key elements in the natural adhesive system is essential to replicate the strong, instant, and durable wet adhesion of the marine sessile organism.
Characterization of natural and Ca2+ modified clinoptilolite for its application in gas separation processes (2015)

This research shows the chemical modification of natural Clinoptilolite Zeolite that is produced in Mexico. The aim of this work is to increase the Ca++ ions concentration, in order to improve the N2 adsorption when this zeolite is used as filler in the preparation of hybrid membranes, with possible application in gas mixtures separation. At the first step, chemical bonding vibrations of the natural Zeolite were determined by Fourier transform infrared spectroscopy (FT-IR) and its thermal stability by Thermogravimetric Analysis (TGA). Clinoptilolite Zeolite was modified with CaCl2 solutio to replace Na+ for Ca++ cations into the Zeolite microstructure. The modified samples were characterized by quantitative analyses using atomic absorption and a comparative semi-quantitative analysis by scanning electron microscopy with spectrometer of energy dispersive (SEM-EDS). The result shows that the chemical modification was obtained in the external surface as well as in the internal cavities of the zeolite.
Heteroarylation of Azine N-Oxides (2012)

Azine &lt;i&gt;N&lt;/i&gt;-oxides undergo highly regioselective metalation with TMPZnCl·LiCl under mild conditions. A palladium-catalyzed Negishi cross-coupling reaction of the resulting organozinc species with heteroaromatic bromides provides heterobiaryls specifically oxidized at one nitrogen position in up to 95% yield.
Pesquisa poblacional de cáncer gástrico en pacientes sintomáticos digestivos, período 1996-2000 (2001)

Gastric cancer was detected in 1.2% of symptomatic adult patients subjected to an upper gastrointestinal endoscopy.
Intraperitoneal Instillation of Lidocaine Improves Postoperative Analgesia at Cesarean Delivery: A Randomized, Double-Blind, Placebo-Controlled Trial (2016)

The use of intraperitoneal instillation of lidocaine improves early postoperative pain management after cesarean delivery. Furthermore, it reduces the number of women requesting systemic opioids in the immediate postpartum period. Women undergoing peritoneal closure may particularly benefit from this intervention.
Effects of Feeding Frequency on the Lying Behavior of Dairy Cows in a Loose Housing with Automatic Feeding and Milking System (2019)

Management systems in modern dairy farms is an important issue in relation to animal comfort and welfare. The objective of this study was to determine the effect of feed delivery frequency on the behavior patterns, visits to an automatic milking system (AMS) and on milk production of lactating dairy cows. The study was conducted on a commercial dairy farm with automatic feeding and milking systems. Feeding treatments consisted of two different frequencies, high feed delivery frequency (11 deliveries per day) and low feed delivery frequency (six deliveries per day). Lying behavior of 20 dairy cows was electronically monitored. The results obtained showed that 11 deliveries per day feed delivery frequency decreases the number of long-duration lying bouts, which may indicate that a very high feeding frequency disturbs the cows during their resting periods and thus influences both animal comfort and milk production. High feeding frequency may disturb the duration of lying bouts and alter the pattern of lying behavior throughout the day, affecting mainly the lying time during the 60 min before and following the provision of fresh feed. Delivering feed at a low frequency allow cows to distribute more evenly their lying time over the course of the day and improve their utilization of an AMS.
1-Tb/s transmission experiment (1996)

A 1-Tb/s aggregate capacity (50 channels each at 20 Gb/s) was transmitted through 55 km of nonzero-dispersion fiber. Fifty channels were generated by polarization multiplexing 25 wavelengths.
Ovarian Monocyte Progenitor Cells: Phenotypic and Functional Characterization (2005)

Leukocytes of the macrophage lineage are abundant in the ovarian tissues and have an important function in both follicular development and regression of postovulatory follicles. In this study, we tested the hypothesis that continuous production of macrophages in the ovarian stroma is maintained by a resident population of progenitors. We established a long-term culture of ovarian follicular stromal cells from BALB/c and green fluorescent protein-transgenic (GFP-TG) C57BL/6 mice. Nonadherent cells were collected and tested for hematopoietic function in vitro and in vivo. Histological and ultrastructural analyses revealed a homogenous population of monocyte-like rounded cells. Nonadherent cells continued to proliferate in culture for several months without senescence. When plated at very low density in methylcellulose, these cells formed colonies consisting of monocyte-like cells. Ovarian monocyte-like cells reacted with CD45, CD11b, CD11c, and Ly6-Gr-1 cell surface markers. A distinct CD45low population within these cells reacted with CD117 (C-kit) surface marker, suggestive of a primitive hematopoietic progenitor. Fifty thousand nonadherent cells failed to provide radioprotection to lethally irradiated mice and thus were not considered to be equivalent to pluripotent hematopoietic stem cells. Ovarian nonadherent stromal cells were positive for alkaline phosphatase but lacked embryonic cell antigens stage-specific embryonic antigen (SSEA-1) and Oct-4. We conclude that in the ovaries, a higher requirement for macrophages is provided by a resident stromal population of progenitors whose progeny is restricted to the production of cells of the monocyte-macrophage lineage.
Thrust Constant and Magnetic Material of Linear DC Motor (1998)

The thrust of a linear DC motor (LDM) depends on the magnetic characteristics of the magnetic material used for the yokes. It is thus necessary to clarify the relation of this material and the thrusts in order to design LDMs easily. This paper considers the relation for a thin (under 40-mm-thick) LDM with a long stroke (105 mm) on the basis of measurements. The results of the measurements were as followings; (1) the maximum magnetic flux density shows a tendency to be saturated at 10 kA/m in the five measured magnetic materials, (2) the thrust constant was saturated, and (3) the saturated value of the thrust constant of LDMs is proportional to the maximum magnetic flux density of the magnetic material used for the center yoke.
UNSUPERVISED FUZZY CLUSTERING USING WEIGHTED INCREMENTAL NEURAL NETWORKS (2004)

A new more efficient variant of a recently developed algorithm for unsupervised fuzzy clustering is introduced. A Weighted Incremental Neural Network (WINN) is introduced and used for this purpose. The new approach is called FC-WINN (Fuzzy Clustering using WINN). The WINN algorithm produces a net of nodes connected by edges, which reflects and preserves the topology of the input data set. Additional weights, which are proportional to the local densities in input space, are associated with the resulting nodes and edges to store useful information about the topological relations in the given input data set. A fuzziness factor, proportional to the connectedness of the net, is introduced in the system. A watershed-like procedure is used to cluster the resulting net. The number of the resulting clusters is determined by this procedure. Only two parameters must be chosen by the user for the FC-WINN algorithm to determine the resolution and the connectedness of the net. Other parameters that must be specified are those which are necessary for the used incremental neural network, which is a modified version of the Growing Neural Gas algorithm (GNG). The FC-WINN algorithm is computationally efficient when compared to other approaches for clustering large high-dimensional data sets.
Research on the influence of large scale offshore wind turbines integrated into Jiangsu power system (2021)

In recent years, the great progress has been made in the development of offshore wind power in Jiangsu. The scale of offshore wind power in operation has ranked the first in China, and it is expected that the scale will reach 12870MW in the end of the "14th Five-Year Plan". With the explosion and significant growth of offshore wind power, greater challenges in terms of wind power absorption and system safety will be induced in Jiangsu power system. Simultaneously, the offshore distances of wind power exploitation are getting farther and farther. For some of the approved offshore wind power projects, they will utilize the flexible direct-current (DC) transmission technology to satisfy the demands of long geographical distances. With the widespread application of flexible DC transmission technology in planned offshore wind power projects, the controllability of wind power transmission systems can be improved, but there are also new risks are introduced, such as providing short-circuit currents to the transmission system, sub/super-synchronous oscillations induced from control systems of power electronic equipment and integrated power systems. Considering the development scale of offshore wind power, operation modes and structure characteristics in Jiangsu during "14th Five-Year Plan", influences of large-scale offshore wind turbines integrated to the transmission power system are discussed, through short-circuit currents induced, voltage stability, sub/super-synchronous oscillations. Corresponding improvement measures are put forward.
i g u n−A program for the simulation of positive ion extraction including magnetic fields (1992)

i g u n is a program for the simulation of positive ion extraction from plasmas. It is based on the well known program egun for the calculation of electron and ion trajectories in electron guns and lenses. The mathematical treatment of the plasma sheath is based on a simple analytical model, which provides a numerically stable calculation of the sheath potentials. In contrast to other ion extraction programs, igun is able to determine the extracted ion current in succeeding cycles of iteration by itself. However, it is also possible to set values of current, plasma density, or ion current density. Either axisymmetric or rectangular coordinates can be used, including axisymmetric or transverse magnetic fields.
Surgery for Metastatic Spinal Disease in Octogenarians and Above: Analysis of 78 Patients (2021)

In octogenarians undergoing surgery with instrumentation for spinal metastases, the median overall survival is 11.6 months. There is an increased complication rate, but only 7% are life-threatening or fatal. Patients are at increased risk for complications and mortality particularly when performing decompression with stabilization, with increasing intraoperative blood loss, and with cervical/cervicothoracic tumors.
Gating kinetics of the Ca channel. (1984)

Gating kinetics of the Ca channel have been studied recently by applying a cell attached patch clamp and a whole cell recording techniques to the rat pituitary cell line, GH3, and to the hair cells dissociated from a chick vestibular organ. In both preparations, Ca channels were gated open by depolarizing command pulses and were not inactivated. The activation kinetics were reasonably fitted by the mm2 kinetic model, while the steady-state noise analysis indicated a presence of much faster opening-closing kinetics in the gating mechanism. The fast opening-closing gating mechanism was observed in the Ba cullents passing through a single Ca channel. Steady-state noise analyses and single channel Ba currents suggest a presence of dual gates in the Ca channel; the one may be a voltage dependent slow gate which operates on a reaction scheme analogous to the mm2 process, and the other may be a less voltage dependent fast gate which seems operating independent of the slow gate.
Effect of Cr and Fe doping on the transport and magnetic properties of the low-bandwidth bilayered manganiteSm1.4Sr1.6Mn2O7 (2002)

The resistivity under different magnetic fields and the magnetization of Cr- and Fe-doped ${\mathrm{Sm}}_{1.4}{\mathrm{Sr}}_{1.6}{\mathrm{Mn}}_{2}{\mathrm{O}}_{7}$ have been measured. Fe and Cr doping affect differently. With increase of Cr content the metal-insulator (M-I) transition temperature ${(T}_{\mathrm{MI}})$ is shifted to lower temperature, whereas even with 1% Fe doping M-I transition disappears and reappears with the application of 2 T magnetic field. This may be due to the fact that Fe doping induces magnetic disorder which strongly localizes the charge carriers. The most of the presently studied samples exhibit huge magnetoresistance (MR) and the maximum MR of 99.49% in 4 T magnetic field has been observed for 1% Cr-doped sample. Besides the fact that the ground state of all the samples is antiferromagnetic the magnetization data indicate the existence of ferromagnetic clusters except the 5% Fe doped sample which shows spin-glass-like behavior.
Highly transferable atomistic machine-learning potentials from curated and compact datasets across the periodic table (2023)

Machine learning atomistic potentials (MLPs) trained using density functional theory (DFT) datasets allow for the modeling of complex material properties with near-DFT accuracy while imposing a fraction of its computational cost.
The β‐cleavage reaction in ethers (1970)

Abstract β‐Cleavage in n‐butyl ethyl ether occurs neither by simple bond fission with oxiranium ion formation nor by a mechanism analogous to the γ‐cleavage reaction in carbonyl compounds, but instead it involves skeletal rearrangement within the butyl chain.