gebhart/patrepeval huggingface dataset:
Testin Induction: The Role of Cyclic 3′,5′-Adenosine Monophosphate/Protein Kinase A Signaling in the Regulation of Basal and Lonidamine-Induced Testin Expression by Rat Sertoli Cells1 (2000)

Results of previous in vitro and in vivo studies have illustrated that the expression of testin by Sertoli cells is tightly associated with the disruption of Sertoli-germ cell junctions. In the present study, treatment of rats with cadmium chloride (CdCl(2)), which disrupted the inter-Sertoli tight junctions, failed to induce any changes in testicular testin expression. In contrast, lonidamine, an antispermatogenic drug that rearranges the Sertoli cell membrane microfilament structure causing a disruption of Sertoli-germ cell adhesion junctions, induced a drastic increase in testicular testin expression when administered orally. Lonidamine-induced Sertoli cell testin expression involved both ongoing RNA and de novo protein synthesis. Basal testin expression remained stable during the 27-h incubation with actinomycin D but required de novo protein synthesis in vitro. An inhibitor of protein kinase A, Rp-cAMPS, caused a 50% inhibition of Sertoli cell testin expression at 10 microM within 24 h. A biphasic response was noted in testin expression when forskolin was included in the Sertoli cell culture, and high concentrations of cAMP analogues (1 mM) rapidly reduced testin expression. However, lonidamine can abolish the inhibitory effect of cAMP analogues on Sertoli cell testin expression. These results illustrate that the induction of testin expression may involve several signal transduction pathways.
Prevention of hyaline membrane disease. (1973)

The articles by Liggins and Howie and Baden, et al. in this issue of Pediatrics are of great interest to perinatologists because they describe efforts to extend to premature infants results of recent studies on maturation of lungs of lambs and rabbits in the prevention of hyaline membrane disease. The two reports provide both promise and caution. When labor can be delayed at least 24 hours in infants under 32 weeks, infusion of betamethasone into the mother can prevent respiratory distress in the infant. Results in infants over 32 weeks9 gestation suggest a positive benefit, but the number of infants in the series was too small to reach statistical significance.
Transport of methane in the stratosphere associated with the breakdown of the Antarctic polar vortex (2002)

Transport of methane associated with the polar vortex and its breakdown was observed by the data from the Improved Limb Atmospheric Spectrometer (ILAS) during November and December of 1996. The zonal mean mixing ratio in the middle stratosphere at high latitudes in the Southern Hemisphere increased rapidly during the period, and the vertical gradient of methane sometimes showed an unusual reversal. The reversal of the vertical gradient confirms that the erosion of the vortex and the subsequent breakdown occurs in the upper stratosphere first and descends with time. The variation of the tracer mixing ratio was investigated with respect to the boundary of the polar vortex. The mixing ratios inside and outside of the polar vortex evolved with distinctive patterns with time. The small difference in methane between inside and outside of the vortex in the upper stratosphere is presumably a result of the vortex erosion prior to November. Also, the small difference between inside and outside of the vortex in the lower stratosphere confirms the weak barrier effect of the polar vortex on that altitude. High concentrations of methane observed inside the vortex show mixing of lower‐latitude air into the vortex. An RDF calculation confirms the behavior of methane transport into the vortex.
The first example of a paraben‐dependent antibody to an Rh protein (2001)

This antibody likely detects a neoantigen formed between active compounds and RBC membranes. Review of the structure of active compounds suggests that proximity between methyl and hydroxyl groups is important for binding with RBC membranes. The role of RhD is unclear; no single portion of RhD protein appears to be implicated.
The role of HDAC10 in lysosomal stress-response mechanisms (2017)

Neuroblastoma is the most common solid extracranial childhood malignancy and the response of high-risk patients to chemotherapy is poor, underlining the need for novel treatment regimens. Previous data from our lab indicate that histone deacetylase 10 (HDAC10) is important for the homeostasis of lysosomes, i.e. acidic vesicular organelles that are involved in the degradation of various biomolecules. These organelles are of central importance in cellular stress resistance mechanisms such as macroautophagy, a starvation-induced degradation process that allows for the recycling of cellular components such as aged or redundant organelles and protein aggregates. Indeed, it was shown that inhibition of HDAC10 sensitizes neuroblastoma as well as medulloblastoma cells to chemotherapeutic agents, making HDAC10 a promising and druggable target for treatment of therapy-resistant tumor entities.
Gonadal function following chemotherapy for childhood Hodgkin's disease (1996)

Gonadal function was assessed in 101 postpubertal subjects after chemotherapy for childhood Hodgkin's disease. All had received ChlVPP (chlorambucil, vinblastine, procarbazine, and prednisolone) chemotherapy alone, with no radiotherapy below the diaphragm. Gonadotropin levels were available in 46 (79.3%) male and 32 (74.4%) female subjects. The mean age at diagnosis in the male cohort was 12.2 years (range 8.2-15.3) and in the females 13.0 years (9.0-15.2). The males and the females were studied at a median of 6 years (range 2.5-11.1) and 4.3 years (range 1.9-11.5) from diagnosis, respectively. Forty-one (89.1%) male subjects had elevated follicle-stimulating hormone (FSH) levels, confirming severe germinal epithelial damage. Germinal epithelial damage was seen in subjects up to 10 years out of therapy. Subtle Leydig cell dysfunction was identified in 24.4% with raised luteinzing hormone (LH) levels. All subjects, however, progressed spontaneously through puberty. Seventeen (53%) women had raised gonadotropin levels, with variable estradiol levels. Of these, 10 subjects presented with symptomatic ovarian failure and 6 received hormone replacement therapy (HRT). Nine women had 11 successful pregnancies, two of whom had previously had symptoms of ovarian failure with one requiring HRT. A much higher prevalence of ovarian failure has been observed, than has previously been considered in the prepubertal and pubertal female following combination chemotherapy. These conclusions have important implications for future counseling, management, and research in this population.
Bubble Column Reactors and Fischer-Tropsch Synthesis (1995)

Abstract Three-phase slurry bubble column reactors have been used extensively in a number of chemical, petrochemical, and biochemical process engineering applications. For the success of these operations and their large scale industrial exploitation, it is essential that their transport and chemical characteristics be adequately understood on a mechanistic basis so that appropriate design criteria and optimum operating conditions can be established. It is the purpose of this review to present such available knowledge in relation to chemical catalytic operations. The mass transfer characteristics, catalytic activity, and mixing patterns of different phases necessitate a detailed understanding of the hydrodynamic behavior and catalyst dispersion in slurry bubble column reactors. The current status of these aspects is presented, discussed, and assessed in this review. Chemical and biochemical reactions are exothermic in nature and hence efficient heat removal devices must be installed in the reactor to preserve its isothermal behavior and chemical catalytic activity by avoiding temperature runaway. Extensive work recently conducted from this heat transfer viewpoint is reviewed and appraised. The bubble dynamics, and slurry mixing and movement characteristics of such baffled bubble columns are significantly different from those of unbaffled bubble columns. Very limited information is available on baffled bubble column operations and this is reviewed and critically examined. An important application of the slurry bubble column is in the synthesis of fuel gases on suspended catalyst particle surface to produce chemicals. One such example is the Fischer-Tropsch synthesis of hydrogen and carbon monoxide in what is referred to as indirect coal liquefaction technology. Pilot plant efforts of this nature and their successes are briefly mentioned. Mathematical details and models developed from time to time to characterize catalytic bubble column operations are briefly described and discussed. In the context of available information and its integration presented here, the specific needs for future experimental and theoretical research work are pointed out.
ChemInform Abstract: Improved and Scalable Synthetic Route to the Synthon 17‐β‐(2‐Carboxyethyl)‐1,3,5(10)estratriene: An Important Intermediate in the Synthesis of Bone‐Targeting Estrogens. (2010)

Abstract A new route to synthon (V) is presented which overcomes the difficulties of known procedures.
Vers une horloge atomique césium CPT compacte avec un VECSEL bi-fréquence (2019)

National audience
The effect of fluidotherapy on hand dexterity and activities of daily living in patients with edema on stroke (2017)

[Purpose] The purpose of this study was to investigate the effect of fluidotherapy on hand's dexterity and activities of daily living for stroke patients with upper limb edema. [Subjects and Methods] The objective of the present study was to treat 30 stroke patients with a three-week course of fluidotherapy to investigate the efficacy of such therapy for reduction of edema. For accurate baseline and post-intervention assessment of edema volume, hand edema was measured in the morning using a forearm volumeter. [Results] Mean edematous volume in the affected side measured 600.53 ± 29.94 ml prior to intervention, significantly decreasing to 533.53 ± 27.85 ml after three weeks of fluidotherapy. To investigate how such reduction may have enhanced the ability to perform activities of daily living, Korean Version of Modified Barthel Index assessment was performed. The results showed 46.10 ± 4.27 points at baseline and significantly improved to a mean score of 49.96 ± 4.34 points at the time of reassessment. Furthermore, Box and Block Test was performed to investigate hand dexterity. Before fluidotherapy, affected patients transferred 21.13 ± 3.63 blocks in one minute, increasing to 23.20 ± 3.42 blocks transferred in one minute following three weeks of treatment. Although the number of blocks transferred did increase slightly, the difference was not statistically significant. [Conclusion] These findings suggest that using fluidotherapy can reduce edema, and such a reduction can have a positive effect on activities of daily living. Based on our current findings, we hypothesize that long-term fluidotherapy treatment may be more effective in reducing edema.
Lange's handbook of chemistry (1992)

Respected for over seven decades as the standard reference for chemists and chemical engineers, this extensively revised and updated 70th Anniversary Edition of Lange9s Handbook of Chemistry is an enormous compendium of facts, data, and tabular material. Lange9s lists the properties of over 4000 organic and 1400 inorganic compounds. The new edition features new tables covering viscosity, thermal conductivity, critical constants, explosion limits, and vapor density; and for the first time in Lange9s, equations allow the calculation of values such as temperature and pressure.
Development and Evaluation of a Remote Sensing Technique for Determining the Temperature Distribution in Semitransparent Solids (1974)

A technique is presented for recovering the temperature profile in semitransparent solids from remotely sensed spectral emission data. The temperature distribution is determined by iteratively solving the equation governing the emerging spectral emission to recover the profile to best match the emission data. The technique is evaluated using both analytical and experimental emission data. Analytical results show the effect of data error, number of data points, method of representing the temperature profile, and optical thickness range. The method is verified experimentally using Corning Code 7940 fused quartz by comparing recovered temperature profiles with those predicted by a combined conduction-radiation heat-transfer analysis.
A new percutaneous vena cava filter (1983)

A new, percutaneous vena cava filter was developed and tested in 11 dogs. Nitinol wire (0.045 cm diam) spirals were straightened and passed through an 8 French Teflon catheter into the inferior vena cava. The filter resumed its original spiral shape on warming to body temperature and was left in place up to 6 weeks. Long-term patency and capture of injected radiopaque clots were demonstrated. This new filter design may be a simple alternative to currently used implants.
TiN/W double layers as a barrier system for use in Cu metalization (1998)

Copper (cu) is considered as a candidate to replace aluminum based interconnections in integrated circuits, because of its higher electromigration resistance and low electrical resistivity. To fulfill the overall requirements it will be necessary to develop an adequate interconnection system for this material. This includes reliable barriers, but also resulting properties of the whole metalization system like, for example, corrosion resistance, adhesion properties, behaviour during patterning or reliability. This paper discusses both the barrier properties of a TiN(N/Ti 1)/W system and its effect on resulting properties of the deposited Cu film. The copper films were deposited by PVD or CVD.
Lau effect and grating imaging (1982)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text G. J. Swanson and E. N. Leith, "Lau effect and grating imaging," J. Opt. Soc. Am. 72, 552-555 (1982) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Spatial Fano resonance of a dielectric microsphere impinged on by a Bessel beam (2021)

The general concept of Fano resonance is considered so as to show the possibility of this resonance in space. Using a recently found solution for a Bessel wave beam impinging on a dielectric sphere, we analyze the electromagnetic fields near a microsphere with different optical sizes and permittivity values. We theoretically reveal spatial Fano resonance when a resonant mode of the sphere interferes with an amount of non-resonant modes. This resonance results in a giant jump of the electric field behind the sphere impinged on by the first-order Bessel beam. The local minimum of the electromagnetic field turns out to be noticeably distanced from the rear edge of the microsphere. However, this is a near-field effect, and we prove it. We also show that this effect can be utilized for engineering a submicrometer optical trap with unusual and useful properties.
A Low Overhead Fault Tolerant Coherence Protocol for CMP Architectures (2007)

It is widely accepted that transient failures will appear more frequently in chips designed in the near future due to several factors such as the increased integration scale. On the other hand, chip-multiprocessors (CMP) that integrate several processor cores in a single chip are nowadays the best alternative to more efficient use of the increasing number of transistors that can be placed in a single die. Hence, it is necessary to design new techniques to deal with these faults to be able to build sufficiently reliable chip multiprocessors (CMPs). In this work, we present a coherence protocol aimed at dealing with transient failures that affect the interconnection network of a CMP, thus assuming that the network is no longer reliable. In particular, our proposal extends a token-based cache coherence protocol so that no data can be lost and no deadlock can occur due to any dropped message. Using GEMS full system simulator, we compare our proposal against a similar protocol without fault tolerance (TOKENCMP). We show that in absence of failures our proposal does not introduce overhead in terms of increased execution time over TOKENCMP. Additionally, our protocol can tolerate message loss rates much higher than those likely to be found in the real world without increasing execution time more than 15%
Peroneal and tibial intraneural ganglia: correlation between intraepineurial compartments observed on magnetic resonance images and the potential importance of these compartments (2007)

This anatomical compartmentalization of intraneural cysts can be used to explain varied clinical and imaging patterns of cleavage planes for cyst formation and propagation. Compartmentalization elucidates the mechanism for cases of outer epineurial cysts in which there are primary ascent, sciatic cross-over, and descent of the lesion down terminal branches; correlates these cysts' atypical MR imaging features; and contrasts a different pattern of inner epineurial cysts in which ascent and descent occur without cross-over. The authors present data demonstrating that the dynamic phases of these intraneural ganglia frequently involve the sciatic nerve. Their imaging features are subtle and serve to explain the underrecognition and underreporting of the longitudinal extension of these cysts. Importantly, cysts extending to the sciatic nerve are still derived from the superior tibiofibular joint. Combined with the authors' previous experimental data, the current observations help the reader understand intraneural ganglia with a different, deeper degree of anatomical detail.
Improvements of energy efficiency of cascading sorption machines (1996)

General considerations for optimizing cascading cycles were discussed with special reference to a joint French-German research program for generating numerical data for a cascading triple effect system. The objective of the research is to improve the coefficient of performance and the primary energy ratio of absorption chillers. One promising way to achieve this is to employ high-temperature driving heat. One of the accompanying problems of high temperatures in multi-effect cycles is the likelihood of heavy corrosion with ordinary sorption fluids. It was suggested that in cascading cycles, which allow the employment of different working pairs in the different cycles the corrosion problems can be overcome, provided that all units of a cascading cycle have been optimized for coupling. Research currently being planned to find inexpensive, yet reliable components of gas-solid cycles, and to find a suitable and cost-effective way of coupling the periodic topping stage with a continuous cycle, was outlined. 26 refs., 7 figs.
Allelotype of head and neck squamous cell carcinoma. (1994)

To gain a better understanding of the molecular changes in head and neck squamous cell carcinoma, we tested every autosomal arm of 29 primary head and neck tumors for allelic loss. Fifty-eight microsatellite markers were used with at least two-thirds of patients informative for each chromosomal arm tested. A high frequency of allelic loss was found on chromosome 9p where 21 of 29 (72%) tumors had loss of heterozygosity for at least one polymorphic marker on this arm. Chromosomes 3, 11q, 13q, and 17p exhibited loss in over 50% of all informative cases, while chromosomes 4, 6p, 8, 14q, and 19q displayed loss in greater than 35% of all cases tested. Additionally, several other chromosomal arms exhibited loss of heterozygosity in 20 to 30% of tumors tested. This high frequency of allelic loss in these advanced stage neoplasms suggests multiple genetic steps in the progression of head and neck cancer and identifies several putative tumor suppressor loci on affected chromosomes.
Synthesis of N-aryl-1,5,3-dithiazepanes and N-aryl-1,5,3-dithiazocanes in the presence of samarium- and cobalt-containing catalysts (2012)

Efficient procedures were developed for the synthesis of N-aryl-1,5,3-dithiazepanes and N-aryl-1,5,3-dithiazocanes by cyclocondensation of anilines with formaldehyde and α,ω-dithiols (etane-1,2-dithiol and propane-1,3-dithiol), as well as by transamination of N-tert-butyl-1,5,3-dithiazepane or N-tert-butyl-1,5,3-dithiazocane with aromatic amines in the presence of samarium and cobalt complexes.
Fluorescent Probes and Digital Imaging: Where We Are and Where We're Going (2013)

The discovery of green fluorescent protein a half century ago heralded a new and explosive era in microscopy, forever changing the landscape for biology imaging. The ability to fuse a genetically encoded fluorescent probe to an almost-unlimited variety of proteins has enabled scientists to investigate signaling pathways and the movement of intracellular proteins in living cells with unprecedented detail, particularly when coupled with powerful widefield fluorescence and confocal microscopy techniques. Today, using the expanded selection of probes now available, researchers can even monitor multiple proteins simultaneously, in real time. This webinar will investigate how fluorescent protein probes are currently being utilized for live cell imaging, with a focus on applications in cancer research and where newly developed probes might take us in the near future.
Achieving high performance via co-designed virtual machines (2005)

A virtual machine (VM) uses software to support a virtual instruction set architecture on a hardware platjonn executing a native instruction set. By co-designing the hardware and software elements of a VM, and by using an implementation-dependent native instruction set, there will be many new opportunities for improved performance and flexibility. Because the hardware-supported instruction set is implementation dependent, performance optimizations can be more easily passed from software through to hardware, and performance feedback infonnation can be more easily passed from hardware up to the software. Furthermore, optimizations can be performed by software dynamically, as the program runs. A codesigned virtual machine may include adaptive hardware Performance features, continuous hardware performance feedback, and on-the-fly optimizing re-compilation by the VM. Hardware and software can cooperate in jinding instruction level parallelism across large blocks of dynamic instructions, and can eflciently implement of a number of advanced microarchitecture techniques involving control independence, prediction, speculation, and cache hierarchy management.
P‐27: Diffractive Color Splitter for High‐Efficiency Liquid‐Crystal Displays (2015)

Absorptive color filters in LCDs reject more than 70% of their incident light. Here, we designed, fabricated and characterized a high‐efficiency diffractive color‐splitter that is able to redirect light into the Red, Green and Blue color sub‐pixels, and thereby improve light transmission in liquid crystal displays by over 30%.