gebhart/patrepeval huggingface dataset:
Mid Term Load Forecasting of the Country Using Statistical Methodology: Case Study in Thailand (2009)

The paper describes the statistical methodology of multiple linear regression (MLR) and autoregressive integrated moving average (ARIMA) methods for mid term load forecasting of the country. The mid term load forecast has many applications such as maintenance scheduling, fuel reserve planning and unit commitment. However, the monthly peak load is a nonlinear, and non-stationary signal. Therefore, this paper proposed a statistical methodology to solve this problem which using multiple linear regression, and autoregressive integrated moving average, based on historical series of electric peak load, weather, and new economic variables such as consumer price index, and industrial index. This paper focuses on the forecasting of monthly peak load for 12 months ahead. This study focused on the mid term load forecasting of peak load demand for Thailand. Finally, we compared between MLR and ARIMA method that the results obtained the autoregressive integrated moving average method proves to be the best accuracy more than the multiple linear regression method.
X-Linked MTMR8 Diversity and Evolutionary History of Sub-Saharan Populations (2013)

The genetic diversity within an 11 kb segment of the MTMR8 gene in a sample of 111 sub-Saharan and 49 non-African X chromosomes was investigated to assess the early evolutionary history of sub-Saharan Africans and the out-of-Africa expansion. The analyses revealed a complex genetic structure of the Africans that contributed to the emergence of modern humans. We observed partitioning of two thirds of old lineages among southern, west/central and east African populations indicating ancient population stratification predating the out of Africa migration. Age estimates of these lineages, older than coalescence times of uniparentally inherited markers, raise the question whether contemporary humans originated from a single population or as an amalgamation of different populations separated by years of independent evolution, thus suggesting a greater antiquity of our species than generally assumed. While the oldest sub-Saharan lineages, ~500 thousand years, are found among Khoe-San from southern-Africa, a distinct haplotype found among Biaka is likely due to admixture from an even older population. An East African population that gave rise to non-Africans underwent a selective sweep affecting the subcentromeric region where MTMR8 is located. This and similar sweeps in four other regions of the X chromosome, documented in the literature, effectively reduced genetic diversity of non-African chromosomes and therefore may have exacerbated the effect of the demographic bottleneck usually ascribed to the out of Africa migration. Our data is suggestive, however, that a bottleneck, occurred in Africa before range expansion.
Inflammatory Arthritis and Bone Metabolism Regulated by Type 2 Innate and Adaptive Immunity (2022)

While type 2 immunity has traditionally been associated with the control of parasitic infections and allergic reactions, increasing evidence suggests that type 2 immunity exerts regulatory functions on inflammatory diseases such as arthritis, and also on bone homeostasis. This review summarizes the current evidence of the regulatory role of type 2 immunity in arthritis and bone. Key type 2 cytokines, like interleukin (IL)-4 and IL-13, but also others such as IL-5, IL-9, IL-25, and IL-33, exert regulatory properties on arthritis, dampening inflammation and inducing resolution of joint swelling. Furthermore, these cytokines share anti-osteoclastogenic properties and thereby reduce bone resorption and protect bone. Cellular effectors of this action are both T cells (i.e., Th2 and Th9 cells), but also non-T cells, like type 2 innate lymphoid cells (ILC2). Key regulatory actions mediated by type 2 cytokines and immune cells on both inflammation as well as bone homeostasis are discussed.
Forward-Looking Competitive Firm Under Uncertainty, The (1993)

This Article is brought to you for free and open access by the CARD Reports and Working Papers at Digital Repository @ Iowa State University. It has
Simulated conditions of microgravity suppress progesterone production by luteal cells of the pregnant rat. (2001)

The purpose of this study was to assess whether simulated conditions of microgravity induce changes in the production of progesterone by luteal cells of the pregnant rat ovary using an in vitro model system. The microgravity environment was simulated using either a high aspect ratio vessel (HARV) bioreactor with free fall or a clinostat without free fall of cells. A mixed population of luteal cells isolated from the corpora lutea of day 8 pregnant rats was attached to cytodex microcarrier beads (cytodex 3). These anchorage dependent cells were placed in equal numbers in the HARV or a spinner flask control vessel in culture conditions. It was found that HARV significantly reduced the daily production of progesterone from day 1 through day 8 compared to controls. Scanning electron microscopy showed that cells attached to the microcarrier beads throughout the duration of the experiment in both types of culture vessels. Cells cultured in chamber slide flasks and placed in a clinostat yielded similar results when compared to those in the HARV. Also, when they were stained by Oil Red-O for lipid droplets, the clinostat flasks showed a larger number of stained cells compared to control flasks at 48 h. Further, the relative amount of Oil Red-O staining per milligram of protein was found to be higher in the clinostat than in the control cells at 48 h. It is speculated that the increase in the level of lipid content in cells subjected to simulated conditions of microgravity may be due to a disruption in cholesterol transport and/or lesions in the steroidogenic pathway leading to a fall in the synthesis of progesterone. Additionally, the fall in progesterone in simulated conditions of microgravity could be due to apoptosis of luteal cells.
Abstract 467: Immunohistochemical multiplex staining strategies with CD8, CD103, PD-1, FOXP3 and pan melanoma cocktail in tumor infiltrating lymphocytes in melanoma (2016)

Abstract Introduction Tumor-associated immune suppression can lead to defective T-cell mediated antitumor immunity. CD8 T-cells play a critical role in the host defense against cancers and infectious diseases. However, the presence of antigen-specific CD8 T-cells does not always imply that cancers and/or pathogens are efficiently eliminated in the body. In tumor infiltrating lymphocytes (TILS), other markers including CD103, PD-1 and FOXP3 are broadly expressed and have shown a wider range of immunoregulatory and important roles in T-cell activation, T- cell regulatory and programmed cell-death checkpoints. Existing methods can either deliver phenotypic information on homogenous samples such as flow cell cytometry or give immunohistochemical information on single biomarker. However, it would be of advantage to be able to visualize the distributions of multiple biomarkers in TILs that would discriminate stromal cells versus solid tumor. Therefore, a multiplex IHC stain utilizing a melanoma marker as a staining mask that separates the malignant tumor cells from stromal cells maybe a good strategy to facilitate better interpretation. Materials and Methods Monoclonal mouse antibodies to CD8, FOXP3 and PD-1 and rabbit monoclonal antibodies CD8, CD103 and PD-1 were optimally tittered for single, double and triple stains and visualized with HRP DAB/Black chromogens and/or alkaline phosphatase fast red/blue chromogens. A mouse monoclonal pan melanoma cocktail was visualized with a fast red chromogen and was used as a staining mask for melanoma tumors cells, but not stromal cells. Results Single, double and triple stains that included pan melanoma cocktail (mask) and CD8, CD103 FOXP3 and PD-1 were successfully established. All double and triple stains gave comparable results to single stains. The co-expression of TILs including CD8 and CD103 or CD8 or FOXP3 and PD-1 was easily identified with contrasting chromogens. TILs in stroma tissues and in malignant tumors cells were easily discriminated with the pan melanoma (mask) that stained only tumor cells with fast red chromogen, but did not stain TILS or stromal tissues. Conclusion The evaluation of TILS in malignant melanoma was enhanced with multiplex stains. TILs in stromal tissues and melanoma tumors cells were easily distinguished with the Pan Melanoma staining mask. These finding may help facilitate important prognostic information and thus may support the rationale for using immunotherapy strategies. Citation Format: David E. Tacha, Wei Yuan, Jillian Terrell. Immunohistochemical multiplex staining strategies with CD8, CD103, PD-1, FOXP3 and pan melanoma cocktail in tumor infiltrating lymphocytes in melanoma. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 467.
Selection of Reference Base Station for TDOA-based Localization in 5G and Beyond IIoT (2022)

Location awareness is fundamental for several applications operating in fifth generation (5G) and beyond wireless networks. To provide accurate localization in 5G networks, time difference-of-arrival (TDOA) measurements are commonly employed. However, the quality of TDOA measurements significantly impacts the localization accuracy and heavily depends on the selection of the reference base station (RBS). Selecting the best RBS is particularly challenging in cluttered environments, such as Industrial Internet-of-Things (IIoT) environments, due to non-line-of-sight conditions and multipath propagation. This paper proposes a machine learning-based method for RBS selection, leveraging the rich information encapsulated in the received signals. The localization performance gain provided by the proposed approach is quantified in the 3rd Generation Partnership Project indoor factory scenario. Results show that the proposed RBS selection method provides a new level of location awareness for applications operating in 5G and beyond environments.
Selective-Area Atomic Layer Deposition (2011)

Atomic layer deposition (ALD) is a method to deposit thin films from gaseous precursors to the substrate layer-by-layer so that the film thickness can be tailored with atomic layer accuracy. Film tailoring is even further emphasized with selective-area ALD which enables the film growth to be controlled also on the substrate surface. Selective-area ALD allows the decrease of a process steps in preparing thin film devices. This can be of a great technological importance when the ALD films become into wider use in different applications. \n\nSelective-area ALD can be achieved by passivation or activation of a surface. In this work ALD growth was prevented by octadecyltrimethoxysilane, octadecyltrichlorosilane and 1-dodecanethiol SAMs, and by PMMA (polymethyl methacrylate) and PVP (poly(vinyl pyrrolidone) polymer films. SAMs were prepared from vapor phase and by microcontact printing, and polymer films were spin coated. Microcontact printing created patterned SAMs at once. The SAMs prepared from vapor phase and the polymer mask layers were patterned by UV lithography or lift-off process so that after preparation of a continuous mask layer selected areas of them were removed. On these areas the ALD film was deposited selectively. \n\nSAMs and polymer films prevented the growth in several ALD processes such as iridium, ruthenium, platinum, TiO2 and polyimide so that the ALD films did grow only on areas without SAM or polymer mask layer. PMMA and PVP films also protected the surface against Al2O3 and ZrO2 growth. \n\nActivation of the surface for ALD of ruthenium was achieved by preparing a RuOX layer by microcontact printing. At low temperatures the RuCp2-O2 process nucleated only on this oxidative activation layer but not on bare silicon.
Semiconductor laser with longitudinal electron-beam pumping and based on a quantum-well ZnCdSe/ZnSe structure grown on a ZnSe substrate by molecular beam epitaxy (1998)

The method of molecular beam epitaxy on a ZnSe substrate was used to grow a ZnCdSe/ZnSe structure with 115 quantum wells. This structure was made up into a cavity which included part of the substrate. Lasing was excited by longitudinal pumping with a scanning electron beam of Ee = 40 — 70 keV energy. At T = 80 K for Ee = 65 keV the threshold current density was 60 A cm-2 and the output power was 0.15 W at the 465 nm wavelength. At T= 300 K the lasing (λ= 474 nm) occurred in the ZnSe substrate.
Does the chemical instability of aspartyl and asparaginyl residues in proteins contribute to erythrocyte aging? The role of protein carboxyl methylation reactions. (1988)

As erythrocytes age in the circulation, their proteins are subjected to a wide variety of spontaneous reactions that lead to the formation of covalent derivatives. In this article, we concentrate on nonenzymatic reactions at aspartyl and asparaginyl residues, both of which are especially vulnerable targets on the protein. These residues can be altered by a combination of deamidation, isomerization, and racemization reactions that form D- and L-aspartyl and D- and L-isoaspartyl residues. We present evidence that two of these modified residues are targets for an enzymatic methyl esterification reaction, and that methylation may represent the means by which cells respond to this type of protein damage. The metabolic fate of the methyl ester is unclear, but in vitro model studies with peptides and proteins suggest that this methylation can lead to the partial repair of the altered protein and can mitigate the loss of protein function.
Performance of Inverted Indices in Distributed Text Document Retrieval Systems (1993)

The performance of distributed text document retrieval systems is strongly influenced by the organization of the inverted index. This paper compares the performance impact on query processing of various physical organizations for inverted lists. We present a new probabilistic model of the database and queries. Simulation experiments determine which variables most strongly influence response time and throughput. This leads to a set of design trade-offs over a wide range of hardware configurations and new parallel query processing strategies. 1 Introduction Full text databases of newspaper articles, journals, legal documents etc. are readily available. These databases are rapidly increasing in size as the cost of digital storage drops, as more source documents are available in electronic form, and as optical character recognition becomes commonplace. At the same time, there is a rapid increase in the number of users and queries submitted to such text retrieval systems. One reason is tha...
Synthesis of N-(1H)-Tetrazole Sulfoximines (2007)

N-(1H)-Tetrazole sulfoximines are readily available by addition of sodium azide to the corresponding N-cyano derivatives in the presence of ZnBr2. The use of these N-(1H)-tetrazoles as intermediates in the synthesis of other N-heterocyclic sulfoximines is demonstrated.
A Study on Gelatin Capsule Brittleness: Moisture Tranfer between the Capsule Shell and Its Content (1998)

Variation in moisture content of the capsule shells either due to the change of storage conditions or the moisture transfer between the capsule shell and its contents may lead to undesired physical properties, such as capsule brittleness and stickiness. DMP 504, a developmental bile-acid sequestrant, is a strongly basic anion-exchange polymer which contains randomly distributed primary, secondary, tertiary, and quaternary amine groups in their hydrochoride salt form. The alkylammonium groups which comprise this polymer form a random network containing a high level of branching and a low level of cross-linking. DMP 504 is very hygroscopic and has a tendency to gain or lose moisture with ease. The transfer of moisture from the capsule shell to DMP 504 powder contained in a hard gelatin capsule can be expected, and if a low water content of the capsule shell is achieved, the capsules become brittle and fracture easily. The sorption isotherm for DMP 504 was generated by storing the drug substance under various relative humidity conditions. After equilibrium, the moisture contents for the samples of individual isotherm points were measured by thermogravimetric analyses. This report applies the sorption-desorption moisture transfer (SDMT) model to predict the equilibrium relative humidity in a system containing DMP 504 in hard gelatin capsules and to establish target loss on drying values for DMP 504 and the capsule shell. Application of this SDMT model resulted in finding a solution to the brittleness problem. The moisture levels of capsule shells and contents for two formulations in a 12-month stability program are also reported here. Results of this study further demonstrate that the SDMT model can be used as a tool to guide the formulator to select optimal initial moisture contents for the empty capsule shell and the formulation to avoid the incidence of brittle capsule problems.
Cylindrical posts of Ag/SiO2/Au multi-segment layer patterns for highly efficient surface enhanced Raman scattering (2012)

We fabricated a regular array of Ag/SiO₂/Au multi-segment cylindrical nanopatterns to create a highly efficient surface enhanced Raman scattering (SERS) active substrate using an advanced soft-nanoimprint lithographic technique. The SERS spectra results for Rhodamine 6G (R6G) molecules on the Ag/SiO₂/Au multi-segment nanopatterns show that the highly ordered patterns and interlayer thickness are responsible for enhancing the sensitivity and reproducibility, respectively, The multi-segment nanopattern with a silica interlayer generates significant SERS enhancement (~EF = 1.2 x 10⁶) as compared to that of the bimetallic (Ag/Au) nanopatterns without a dielectric gap (~EF = 1.0 x 10⁴). Further precise control of the interlayer distances between the two metals plays an essential role in enhancing SERS performance for detecting low concentrations of analytes such as fluorescent (Rhodamine 6G) and DNA molecules. Therefore, the highly ordered multi-segment patterns provide great sensitivity and reproducibility of SERS based detection, resulting in a high performance of the SERS substrate.
A fully integrated planar toroidal inductor with a micromachined nickel-iron magnetic bar (1994)

A fully integrated toroidal inductor is realized on a silicon wafer by using a multilevel metallization technique to fabricate a wrapped coil wound around a micromachined bar of high-permeability magnetic material. In particular, efforts are made to minimize the coil resistance by using thick conductor lines and electroplated vias. In this structure, a 30 /spl mu/m thick nickel-iron permalloy magnetic core is wrapped with 40 /spl mu/m thick multilevel copper conductor lines, constructing a conventional toroidal inductor in planar shape. A closed magnetic circuit (i.e., toroidal) in this inductive component is adopted, where magnetic core bar and wrapped conductor lines are tightly interlinked, so that leakage flux and electromagnetic interference are minimized. For an inductor size of 4 mm/spl times/1 mm/spl times/130 /spl mu/m thickness having 33 turns of multilevel coils, the achieved inductance is approximately 0.4-0.1 /spl mu/H at 1 kHz-1 MHz, corresponding to a core permeability of approximately 800. The measured dc resistance of the conductor lines is approximately 0.3 /spl Omega/. Since this inductive component shows favorable magnetic characteristics as well as electrical properties, it is potentially very useful as a basic inductive component in applications for magnetic microsensors, microactuators, and micromagnetic power devices such as a dc/dc converter.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The Erythropoietin Receptor Transmembrane Domain Mediates Complex Formation with Viral Anemic and Polycythemic gp55 Proteins (2003)

Erythropoietin receptor (EpoR) activation is crucial for mature red blood cell production. The murine EpoR can also be activated by the envelope protein of the polycythemic (P) spleen focus forming virus (SFFV), gp55-P. Due to differences in the TM sequence, gp55 of the anemic (A) strain SFFV, gp55-A, cannot efficiently activate the EpoR. Using antibody-mediated immunofluorescence co-patching, we show that the majority of EpoR forms hetero-oligomers at the cell surface with gp55-P and, surprisingly, with gp55-A. The EpoR TM domain is targeted by gp55-P and -A, as only chimeric receptors containing EpoR TM sequences oligomerized with gp55 proteins. Both gp55-P and gp55-A are homodimers on the cell surface, as shown by co-patching. However, when the homomeric interactions of the isolated TM domains were assayed by TOXCAT bacterial reporter system, only the TM sequence of gp55-P was dimerized. Thus, homo-oligomerization of gp55 proteins is insufficient for full EpoR activation, and a correct conformation of the dimer in the TM region is required. This is supported by the failure of gp55-A-->P, a mutant protein whose TM domain can homo-oligomerize, to fully activate EpoR. As unliganded EpoR forms TM-dependent but inactive homodimers, we propose that the EpoR can be activated to different extents by homodimeric gp55 proteins, depending on the conformation of the gp55 protein dimer in the TM region.
SIRT4 interacts with OPA1 and regulates mitochondrial quality control and mitophagy (2017)

The stress-responsive mitochondrial sirtuin SIRT4 controls cellular energy metabolism in a NAD<sup>+</sup>-dependent manner and is implicated in cellular senescence and aging. Here we reveal a novel function of SIRT4 in mitochondrial morphology/quality control and regulation of mitophagy. We report that moderate overexpression of SIRT4, but not its enzymatically inactive mutant H161Y, sensitized cells to mitochondrial stress. CCCP-triggered dissipation of the mitochondrial membrane potential resulted in increased mitochondrial ROS levels and autophagic flux, but surprisingly led to increased mitochondrial mass and decreased Parkin-regulated mitophagy. The anti-respiratory effect of elevated SIRT4 was accompanied by increased levels of the inner-membrane bound long form of the GTPase OPA1 (L-OPA1) that promotes mitochondrial fusion and thereby counteracts fission and mitophagy. Consistent with this, upregulation of endogenous SIRT4 expression in fibroblast models of senescence either by transfection with miR-15b inhibitors or by ionizing radiation increased L-OPA1 levels and mitochondrial fusion in a SIRT4-dependent manner. We further demonstrate that SIRT4 interacts physically with OPA1 in co-immunoprecipitation experiments. Overall, we propose that the SIRT4-OPA1 axis is causally linked to mitochondrial dysfunction and altered mitochondrial dynamics that translates into aging-associated decreased mitophagy based on an unbalanced mitochondrial fusion/fission cycle.