gebhart/patrepeval huggingface dataset:
Tumors of the cornea and conjunctiva (1994)

This article reviews literature published in 1993 regarding conjunctival and corneal tumors. The pathology and biologic behavior of melanocyte conjunctival lesions remain a source of confusion. To assist in the pathologic evaluation of a pigmented conjunctival tumor, a history including the patient's age, onset, duration and progression of the lesion, and any systemic disease should be provided. Articles examining techniques to assist in the pathologic diagnosis and to assess prognosis of melanocyte conjunctival tumors are discussed. Clinical parameters predictive of recurrence and metastasis of conjunctival melanomas are reviewed. Evidence for a genetic association between dysplastic nevus syndrome and ocular melanomas is presented including the first description of cytogenetics performed on a conjunctival melanoma in a patient with dysplastic nevus syndrome. Conjunctival paraneoplastic pemphigus and case reports of conjunctival and corneal involvement in various neoplastic conditions are also reviewed.
Potassium conductances in tracheal epithelium activated by secretion and cell swelling (1990)

Increased basolateral membrane K conductance accompanies stimulation of Cl secretion across canine trachea. To assess the K conductance properties, we permeabilized the apical membranes with amphotericin B and monitored the current and conductance caused by K flow across the basolateral membranes. Under basal unstimulated conditions, two K conductances could be distinguished by blockers. One was inhibited only by barium; the other was sensitive also to quinidine and lidocaine. The permeabilities of the basal conductance pathways to K and Rb were similar (PK/PRb approximately equal to 1.5). The secretory agonist, epinephrine, selectively increased the quinidine-insensitive conductance, implicating it in the Cl secretory response. Cell swelling induced a third conductance with a low permeability to Rb (PK/PRb approximately equal to 10) that was quinidine sensitive. In tissues not treated with amphotericin, neither quinidine nor Rb-for-K replacement inhibited transepithelial Cl secretion. Thus neither of the quinidine-sensitive K conductances (basal or swelling induced) contribute to the increase in basolateral K conductance during Cl secretion. Cell shrinkage inhibited all three conductances and secretion, suggesting that the initial priority of the cell is volume regulation.
Immunofluorescent localization of the third and the fourth component of complement in synovial tissue from patients with rheumatoid arthritis. (1967)

Abstract Synovial tissues obtained by needle biopsy from 8 patients with rheumatoid arthritis of duration from 112 to 31 years were studied with direct immunofluorescent techniques. Tissue localization of 7S γ-globulin (γG) in synovial membranes, synovial margins, and in adventitia of vessels was closely approximated by concurrent staining for the third and the fourth components of complement. Blocking of tissue bound rheumatoid factors with unconjugated aggregates of γG did not diminish the fluorescent patterns obtained with anticomplement component antisera. These findings suggest a different pattern of localization for rheumatoid factors and tissue bound-complement components.
Preparation of 3D open ordered mesoporous carbon single-crystals and their structural evolution during ammonia activation (2018)

Three-dimensional ordered mesoporous polymer (OMP) single-crystals were synthesized for the first time via a simple soft-template strategy. Ordered mesoporous nitrogen-doped carbon (OMNC) was obtained through carbonization of OMP and post ammonia activation. The evolution of specific surface area, pore volume, and nitrogen content, and species of OMNC were systematically investigated by adjusting the activation temperature and time.
La construcción de conocimiento y la integralidad de funciones en la agenda actual de la extensión universitaria (2019)

The present work aims to address the issue of knowledge construction in relation to extension practices, linking the relevance of this topic with two main issues. On the one hand, with the need to revalue nonacademic knowledge if the University intends to establish a dialogue with the community to which it belongs. On the other hand, with the structuring character of knowledge, not only for extension, but also for the rest of the substantive functions of the University.From this, the analysis of integrality is derived not only as theme of the university extension agenda but also of what has been called the Second University Reform. The epistemological problem that the work addresses is also articulated with questions of an ethical and political nature.
Stimulation of B10.BR T cells with superantigenic staphylococcal toxins. (1990)

The Staphylococcus aureus enterotoxins are known to be potent T cell activators, stimulating cell proliferation and lymphokine production. Two additional S. aureus proteins, exfoliating toxin and toxic shock syndrome toxin, share these properties. Recently these molecules have been termed "super-antigens" because of their ability to bind to class II MHC molecules and thus form ligands that interact with TCR in an unconventional manner. In this paper we show that each toxin stimulates mouse T cells bearing receptors that include particular V beta regions, almost regardless of the other variable receptor components. In addition, different toxins have different specificities for V beta.
Cytotoxic Terpene Quinones from Marine Sponges (2010)

The 1,4-benzoquinone moiety is a common structural feature in a large number of compounds that have received considerable attention owing to their broad spectrum of biological activities. The cytotoxic and antiproliferative properties of many natural sesquiterpene quinones and hydroquinones from sponges of the order Dictyoceratida, such as avarol, avarone, illimaquinone, nakijiquinone and bolinaquinone, offer promising opportunities for the development of new antitumor agents. The present review summarizes the structure and cytotoxicity of natural terpenequinones/hydroquinones and their bioactive analogues and derivatives.
Subspace Embeddings and $\ell_p$-Regression Using Exponential Random Variables (2013)

Oblivious low-distortion subspace embeddings are a crucial building block for numerical linear algebra problems. We show for any real $p, 1 \leq p &lt; \infty$, given a matrix $M \in \mathbb{R}^{n \times d}$ with $n \gg d$, with constant probability we can choose a matrix $Π$ with $\max(1, n^{1-2/p}) \poly(d)$ rows and $n$ columns so that simultaneously for all $x \in \mathbb{R}^d$, $\|Mx\|_p \leq \|ΠMx\|_{\infty} \leq \poly(d) \|Mx\|_p.$ Importantly, $ΠM$ can be computed in the optimal $O(\nnz(M))$ time, where $\nnz(M)$ is the number of non-zero entries of $M$. This generalizes all previous oblivious subspace embeddings which required $p \in [1,2]$ due to their use of $p$-stable random variables. Using our matrices $Π$, we also improve the best known distortion of oblivious subspace embeddings of $\ell_1$ into $\ell_1$ with $\tilde{O}(d)$ target dimension in $O(\nnz(M))$ time from $\tilde{O}(d^3)$ to $\tilde{O}(d^2)$, which can further be improved to $\tilde{O}(d^{3/2}) \log^{1/2} n$ if $d = Ω(\log n)$, answering a question of Meng and Mahoney (STOC, 2013). We apply our results to $\ell_p$-regression, obtaining a $(1+\eps)$-approximation in $O(\nnz(M)\log n) + \poly(d/\eps)$ time, improving the best known $\poly(d/\eps)$ factors for every $p \in [1, \infty) \setminus \{2\}$. If one is just interested in a $\poly(d)$ rather than a $(1+\eps)$-approximation to $\ell_p$-regression, a corollary of our results is that for all $p \in [1, \infty)$ we can solve the $\ell_p$-regression problem without using general convex programming, that is, since our subspace embeds into $\ell_{\infty}$ it suffices to solve a linear programming problem. Finally, we give the first protocols for the distributed $\ell_p$-regression problem for every $p \geq 1$ which are nearly optimal in communication and computation.
Tropical Diseases of Military Importance: A Centennial Perspective (2010)

Vector-borne diseases stand out as major concerns for military deployments. Of particular concern are malaria, arboviral diseases and, more recently, leishmaniasis. Vaccine preventable diseases also remain important globally. Other common problems, for example diarrhoeal disease and non-infectious hazards, such as trauma, also need to be addressed.
Deformation potentials of the E1(TO) mode in AlN (2002)

The deformation potentials of the E1(TO) mode in AlN are experimentally determined by combining infrared reflection spectroscopy and x-ray diffraction measurements and using a reported value of the Raman-stress factor for hydrostatically stressed bulk AlN. The deformation potentials are found to strongly depend on published stiffness constants of AlN. A comparison with earlier theoretically calculated values of the deformation potentials is made.
2-D frequency domain Kalman filter with fuzzy gearshiftingforobject velocity estimation in image sequences (1995)

A 2-D object velocity estimation for image sequences with fuzzy gearshifting is outlined. An extended Kalman filter is used to estimate the 2-D velocity of an object in image sequences. The fuzzy gearshifting mechanism is applied to the Kalman filter to improve the transient response and reduce the steady-state error.
Supplementary Figure 1 from A Novel Aldehyde Dehydrogenase-3 Activator Leads to Adult Salivary Stem Cell Enrichment <i>In Vivo</i> (2023)

&lt;p&gt;PDF file - 600K&lt;/p&gt;
Luminosity and Pressure Aberrations in Detonating Nitromethane Solutions (1969)

Smear camera photographs of the detonation process in nitromethane and in its solutions with acetone often show dark striations and/or larger dark regions. Photographic evidence now presented leads to the conclusion that these two characteristic entities are not the same, although both may indicate local nonreaction sites. New data is presented showing the possibility of detonation buildup in large dark regions as evidenced by brightly luminous interaction figures and strong local pressure differences.
Phosphites as Ligands for Efficient Catalysis of Heck Reactions (1998)

The palladium-catalyzed Heck reaction of aryl halides in the presence of phosphite ligands is described for the first time. Aryl bromides and even electron deficient aryl chlorides can be coupled efficiently (turnover numbers up to 31 000) with different olefins using palladium/trialkyl- or triaryl phosphite mixtures as catalysts.
A Comparison in Patient Comfort Using Conventional Syringe and Needleless Jet Anesthesia Technique in Periodontal Surgery—A Split-Mouth Randomized Clinical Trial (2022)

<i>Background and Objectives:</i> Periodontal surgery requires local anesthetic coverage to alleviate patient discomfort. Needles and injections can engender feelings of fear and anxiety in individuals. This study aimed to assess the level of comfort and anxiety in patients during the administration of local anesthesia using needleless jet anesthesia (JA) when compared to a conventional syringe (CS) in periodontal surgery. <i>Method and Materials:</i> 60 sites were designated for injection in a split-mouth design in 30 subjects who required periodontal surgery. Local anesthesia was administered in two appointments scheduled one week apart using either a JA system or a CS. The Visual Analogue Scale (VAS), Verbal Rating Scale (VRS), and Beck's anxiety inventory were used to report the pain and anxiety levels while injecting local anesthesia. Statistical analysis of the results was performed using the Shapiro-Wilks test and Paired t-test. <i>Results:</i> Patients reported greater comfort with JA. The VAS and VRS values were statistically significant-(<i>p</i> = 0.003) and (<i>p</i> = 0.001), respectively. Patients showed fear and were nervous about receiving a local anesthetic using a CS. A few subjects experienced lingering pain with the CS, whereas greater comfort and no lingering soreness were reported post-operatively at the site of JA administration. <i>Conclusions:</i> This study provides the first comprehensive assessment of using JA for periodontal surgical procedures. Lower pain scores were consistently observed with the use of jet injectors. Patients were at ease and reported lesser anxiety and greater comfort with jet injectors, making it ideally suited for providing local anesthesia in periodontal surgery.
INTELLIGENT VISION SYSTEMS FOR ROBOTIC APPLICATIONS (2008)

Vision-based sensors are a key component for robot-systems, where many tasks depend on image data. Realtime control constraints bind a lot of processing power for only a single sensor modality. Dedicated and distributed processing resources are the "natural" solution to overcome this limitation. This paper presents experiments, using embedded processors as well as dedicated hardware, to execute various image (pre)processing tasks. Architectural concepts and requirements for intelligent vision systems have been acquired.
Induction of the Lung Myofibroblast PDGF Receptor System by Urban Ambient Particles from Mexico City (1998)

Platelet-derived growth factor (PDGF) and its receptor system regulate mesenchymal cell proliferation. We recently reported that emission-source fly-ash particles and asbestos fibers induce the PDGF alpha-receptor through a macrophage-dependent pathway, and upregulation of this receptor greatly enhances the mitogenic response of lung myofibroblasts to PDGF (Lindroos and colleagues, Am. J. Respir. Cell Mol. Biol. 1997;16:283-292). In the present study we investigated the effect of particulate matter <= 10 micrometers in size (PM10) from the southern, central, and northern regions of Mexico City on PDGF receptor induction and compared these urban, ambient particles with Mt. St. Helen's volcanic ash particles as a negative control. All Mexico City PM10 samples, but not volcanic ash, stimulated rat alveolar macrophages to secrete a soluble, upregulatory factor(s) for the PDGF alpha-receptor on early passage rat lung myofibroblasts. The macrophage-derived upregulatory activity was blocked by the interleukin (IL)-1 receptor antagonist. The ability of PM10 to stimulate IL-1beta release was blocked in part by a recombinant endotoxin neutralizing protein (rENP). Lipopolysaccharide/endotoxin (LPS) and vanadium, both constituents that were present within these PM10 samples, also stimulated macrophages to secrete factor(s) that upregulated PDGF-Ralpha on lung myofibroblasts. Direct exposure of myofibroblasts to PM10 also elicited upregulation of the PDGF alpha-receptor, and this effect was blocked by rENP and mimicked by LPS, but not vanadium. These findings suggest that PM10 particles induce expression of the PDGF receptor system through macrophage-dependent and -independent mechanisms involving endotoxin and metals.
Abstract 1705: Slide-based multi-parametric immunophenotyping of human blood samples by cyclic immunofluorescence using the Accucyte-CyteFinder system (2017)

Abstract Immunophenotyping is an approach to measuring the abundance and functional state of immune cells as a means to understand mechanisms of homeostasis, identify biomarkers of disease, and measure therapeutic and adverse responses to drugs such as immune checkpoint inhibitors. Such studies are conventionally performed using flow cytometry together with combinations of immunomarkers that allow for identification of cell type, maturation state, and activation status. Here we describe a method for profiling circulating human leukocytes with highly-multiplexed immunofluorescence microscopy. The method has distinct advantages over flow cytometry in that it has greater sensitivity for detecting rare cell populations, allows for repeat analysis and long-term storage of precious biological samples, and obviates the requirement for spectral deconvolution. Using an open-source multiplexed immunofluorescence protocol referred to as cyclic immunofluorescence (CycIF), and commercially available reagents and instruments (AccuCyte and CyteFinder; RareCyte Inc.), we show that imaging can provide 16-plex, single-cell intensity data in addition to information on cellular morphology. Analytic technologies borrowed from the field of mass cytometry, such as ViSNE and Phenograph, allow for downstream phenotypic analysis and high-dimensional biomarker discovery. Current efforts now aim to expand the number of validated immune targets and combine imaging with single-cell picking and sequencing technologies. Citation Format: Jia-Ren Lin, Lance U'Ren, Gregory J. Baker, Joshua J. Nordberg, Zoltan Maliga, Jackie L. Stilwell, Eric P. Kaldjian, Peter K. Sorger. Slide-based multi-parametric immunophenotyping of human blood samples by cyclic immunofluorescence using the Accucyte-CyteFinder system [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 1705. doi:10.1158/1538-7445.AM2017-1705
Ein neues Verfahren zur Herstellung von Essigsäureäthylester unter Anwendung instationärer Prozeßführung (1977)

When adding C2H4 to AcOH over a H2SO4-SiO2 catalyst to give AcOEt, the activity of the solid-bed catalyst depended on the surface of the carrier; best results were obtained with SiO2 with a surface area of 120 m2/g. In a stationary process, the space-time-yield curve peaked at .apprx.130 h operating time, then decreased to approx. half this value over the next 300 h, whereas in a nonstationary process, the space-time-yield curve peaked at 100 h and did not decrease during the next 400 h of operation. [on SciFinder (R)]
Modeling of the Degradation of Poly(ethylene glycol)-co-(lactic acid)-dimethacrylate Hydrogels (2017)

Because of their similarity with extracellular matrix, hydrogels are ideal substrates for cell growth. Hydrogels made of synthetic polymers are excellent alternatives to natural ones and offer the key advantage of precisely controllable degradation times. In this work, hydrogels have been prepared from modified poly(ethylene glycol) macromonomers, functionalized on both ends first with a few lactic acid units, and then with methacrylate groups. A library of hydrogels has been prepared using free-radical polymerization of the macromonomers, by changing both the macromonomer concentration and their type, i.e., the number of lactic acid repeating units. The degradation kinetics of these hydrogels, caused by the hydrolysis of the lactic acid units, have been carefully monitored in terms of swelling ratio, mass loss, and Young’s modulus. A complete mathematical model, accounting for hydrogel degradation, swelling, and reverse gelation, has been developed and used to predict all the measured quantities until complete disappearance of the gels. The model is capable of accurately predicting the time evolution of all the properties investigated experimentally. To the best of our knowledge, this is the first study where such a systematic comparison between model predictions and experimental data is presented.
Proposal for the Reconsideration of the Definition of Gestational Diabetes (2005)

In 1997, the American Diabetes Association (ADA) announced a new diagnostic criterion for diabetes and set the definition of gestational diabetes mellitus (GDM). Before 1991, GDM was defined as “a transient abnormality of glucose tolerance during pregnancy” (2–4). However, the 1997 definition of GDM by the ADA includes diabetes diagnosed during pregnancy. This definition ignores the added risks to the mother and to the fetus when the mother has undiagnosed type 2 diabetes. We propose reconsideration of the definition, which would separate diabetes and slight abnormal carbohydrate, so-called GDM, to provide a better model of care for type 2 diabetic pregnant women.

There are three problems concerning an undiagnosed type 2 diabetic woman that …
Using Fractionated Natural Organic Matter to Quantitate Organic Byproducts of Ozonation (1994)

Abstract An improved procedure was used to isolate and fractionate natural organic matter (NOM) in water for subsequent ozonation and disinfection by-product (DBP) and color removal quantisation. Isolated NOM fractions from two different sources, accounting for approximately 50 to 60% of the dissolved organic material and 60 to 75% of the color, were characterized and then ozonated under conditions approximating those encontered during drinking water treatment. The natural waters also were ozonated. Organic DBPs of either health concern or which may contribute to biological instability of finished water were investigated, including aldehydes, oxoacids and low molecular weight carboxylic acids. pH and ozone dosage were the parameters having the greatest effect on DBP formation. On the basis of UV absorbance measurements, the fulvic acid fractions studied taken together accurately represented the natural water and may be the primary sources of precursor material for aldehydes and oxoacid DBPs. However, as yet unidentified NOM fractions contribute significantly to carboxylic acid formation upon ozonation.
Electrophysiological Effects of Transcranial Direct Current Stimulation on Neural Activity in the Rat Motor Cortex (2020)

Transcranial direct current stimulation (tDCS) is a non-invasive technique that modulates the neuronal membrane potential. We have previously documented a sustainable increase in extracellular dopamine levels in the rat striatum of cathodal tDCS, suggesting that cathodal tDCS enhances the neuronal excitability of the cortex. In the present study, we investigated changes in neuronal activity in the cerebral cortex induced by tDCS at the point beneath the stimulus electrode in anesthetized rats <i>in vivo</i>. Multiunit recordings were performed to examine changes in neuronal activity before and after the application of tDCS. In the cathodal tDCS group, multiunit activity (indicating the collective firing rate of recorded neuronal populations) increased in the cerebral cortex. Both anodal and cathodal tDCS increased the firing rate of isolated single units in the cerebral cortex. Significant differences in activity were observed immediately following stimulation and persisted for more than an hour after stimulation. The primary finding of this study was that both anodal and cathodal tDCS increased <i>in vivo</i> neuronal activity in the rat cerebral cortex underneath the stimulus electrode.
Deep proteomics and phosphoproteomics reveal novel biological pathways perturbed by morphine, morphine‐3‐glucuronide and morphine‐6‐glucuronide in human astrocytes (2020)

Tolerance and hyperalgesia associated with chronic exposure to morphine are major limitations in the clinical management of chronic pain. At a cellular level, neuronal signaling can in part account for these undesired side effects, but unknown mechanisms mediated by central nervous system glial cells are likely also involved. Here we applied data-independent acquisition mass spectrometry to perform a deep proteome and phosphoproteome analysis of how human astrocytes responds to opioid stimulation. We unveil time- and dose-dependent effects induced by morphine and its major active metabolites morphine-3-glucuronide (M3G) and morphine-6-glucuronide that converging on activation of mitogen-activated protein kinase and mammalian target of rapamycin signaling pathways. We also find that especially longer exposure to M3G leads to significant dysregulation of biological pathways linked to extracellular matrix organization, antigen presentation, cell adhesion, and glutamate homeostasis, which are crucial for neuron- and leukocyte-astrocyte interactions.