gebhart/patrepeval huggingface dataset:
Modélisation et identification de systèmes complexes : application à des véhicules routiers en vue de l'étude d'un nouveau système de freinage (1996)

Nous proposons une strategie generale de la recherche d'un modele. Elle consiste a analyser les objectifs, les moyens et le temps disponible, a faire le choix du type de modele, a construire le modele et a effectuer une comparaison iterative des resultats. Nous montrons que l'analyse du systeme gagne en rigueur, que le modele gagne en possibilites d'evolution et en confort d'utilisation, si l'on adopte certaines notions orientee objets. L'etude des elements qui conditionnent le comportement des vehicules illustre la complexite des vehicules et leurs caracteres hautement non - lineaires. L'analyse de la problematique du freinage et de la tenue de route demontre que des etudes monoaxiales du comportement des vehicules ne peuvent etre satisfaisantes pour l'etude de bon nombres de phenomenes. Un vehicule est un systeme complexe, non - lineaire ayant des comportements couples. Des modeles complets et precis des vehicules sont necessaires afin de parfaire la connaissance des phenomenes, d'elaborer, de tester et de valider des solutions modernes, novatrices et performantes. Les modeles elabores sont au nombre de six. Le plus simple d'entre eux represente un quart de vehicule bloque en ligne droite, tandis que le plus complexe est representatif d'un vehicule articule. Les modeles elabores, de type boite grise, maintiennent une correlation et une coherence avec la realite physique du comportement du vehicule d'un niveau eleve tout en offrant une precision importante de la description des phenomenes, offrent une tres bonne precision de calcul en rapport du temps de calcul, sont d'un emploi aise et peuvent etre facilement modifie et enrichi. Les possibilites de ces modeles sont illustrees par un panel de simulations representatives de differentes situations de conduite, par l'etude d'une regulation de freinage par une commande auto-adaptative et par l'analyse de l'influence de differentes politiques de freinage
MetalMUMPs-Based Piezoresistive Strain Sensors for Integrated On-Chip Sensor Fusion (2014)

In this paper, polysilicon-based microelectromechanical system (MEMS) piezoresistive strain sensors manufactured with acoustic emission sensors and accelerometers on the same device are introduced. Three strain sensors are placed in horizontal, vertical, and angled directions to extract the principle strains, and manufactured using MetalMUMPs. The influences of sensor position on the silicon substrate and trenching to the strain transfer from structure under loading to polysilicon layer are numerically demonstrated and experimentally validated. The characterization experiments include monotonic, cyclic, and fatigue mechanical loading and thermal loading. The performance of MEMS strain sensors is compared with conventional metal gauges. While the strain transfer from structure to polysilicon is limited due to the stiffness of package, and the location of strain sensors on the substrate, the gauge factor of MEMS strain sensors is about twice of metal gauges. Combining strain sensors on the same package of other structural health monitoring (SHM) sensors can tackle several limitations of SHM methods, such as the need of redundant measurement to increase the reliability and define idle/active mode of acoustic emission sensor using strain sensor to reduce the power consumption, and enable integrating energy harvesting devices.
Molecular arrangement for twisted nematic liquid crystal displays having liquid crystalline materials with opposite chiral structures (reverse twisted nematic liquid crystal displays) (2009)

It was found that in twisted nematic liquid crystal displays (TN-LCDs) in which the chiral direction of the liquid crystalline (LC) material is opposite to the twist direction determined by the rubbing directions, which are referred to as a reverse twisted nematic LCDs, LC molecules tilt largely without the application of an electric field. Reducing the pitch length of LC materials increases the polar angles of the LC molecules. This phenomenon can be explained by assuming that the stress generated by the helical power being in the opposite direction to the twist direction can be released by increasing the polar angle. The resultant molecular arrangement resembles that of TN-LCDs to which a voltage is applied. By using this LC molecular arrangement, a drastic reduction in the driving voltage of TN-LCDs could be realized. We believe that this method is capable of reducing the driving voltage of TN-LCDs more than other methods.
Resonant interband and intraband tunneling in InAs/AlSb/GaSb double barrier diodes (2002)

We have realized a series InAs/AlSb/GaSb tunneling structures in which both interband and intraband tunneling occur, dependent on injection energy. The baseline structure consists of a single InAs well with GaSb barriers which serve as quantum wells for interband tunneling and barriers for intraband tunneling. At low biases, interband tunneling occurs through a coupled double well structure in the GaSb valence bands. At higher biases, intraband tunneling occurs through the InAs quantum well. The addition of a thin AlSb barrier at different points in the structure changes both the strength and number of peaks in the I-V/G-V characteristics.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Design and implementation of city fire control management system based on GIS (2011)

City fire control system based on GIS is designed and implemented in this paper. The system database consists of metadata database, basic database, thematic database of fire control and 3d database of important fire-control units. The functions of response alarm, map query and space analysis, navigation and positioning of fire engine are implemented in this system. Some key points in system building and using are also illustrated, such as system and data management, the linkage with other departments and acquisition of the latest route information.
TPC2 promotes choroidal angiogenesis and inflammation in a mouse model of neovascular age-related macular degeneration (2021)

Age-related macular degeneration (AMD) is the most common cause of blindness among the elderly and can be classified either as dry or as neovascular (or wet). Neovascular AMD is characterized by a strong immune response and the inadequate release of cytokines triggering angiogenesis and induction of photoreceptor death. The pathomechanisms of AMD are only partly understood. Here, we identify the endolysosomal two-pore cation channel TPC2 as a key factor of neovascularization and immune activation in the laser-induced choroidal neovascularization (CNV) mouse model of AMD. Block of TPC2 reduced retinal VEGFA and IL-1β levels and diminished neovascularization and immune activation. Mechanistically, TPC2 mediates cationic currents in endolysosomal organelles of immune cells and lack of TPC2 leads to reduced IL-1β levels in areas of choroidal neovascularization due to endolysosomal trapping. Taken together, our study identifies TPC2 as a promising novel therapeutic target for the treatment of AMD.
Validation of NASA, NOAA AND ESA mid and thermal infrared data and products using the Lake Tahoe and Salton Sea automated validation sites (2020)

&amp;lt;p&amp;gt;The stated goal of NASA&amp;amp;#8217;s Earth Science Research Program is to utilize global measurements to understand the Earth system and its interactions as steps toward the prediction of Earth system behavior. NASA has identified the provision of well-calibrated, multiyear and multi-satellite data and product series as a key requirement for meeting this goal. In order to help address this goal we have established two automated validation sites where the necessary measurements for validating mid and thermal infrared data from spaceborne and airborne sensors are made every few minutes on a continuous basis.&amp;lt;br&amp;gt;The two automated validation sites are located at Lake Tahoe CA/NV and Salton Sea CA. The Lake Tahoe site was established in 1999 and the Salton Sea site was established in 2008. Lake Tahoe is ideally suited for validation of mid and thermal infrared data for several reasons including its size, homogeneity, elevation, accessibility and composition. In order to use Lake Tahoe for validation, 4 buoys have been deployed. Each buoy includes a custom-built highly accurate (50mK) radiometer measuring the surface skin temperature and several bulk temperature probes that trail behind the buoy. Each buoy includes a logging system with dial-up cellular access and two full meteorological station measuring wind speed, wind direction, relative humidity and net radiation. All the measurements are made every few minutes and downloaded hourly via a cellular modem. The buoy measurements are supplemented with a variety of atmospheric measurements made on-shore. The Salton Sea site was established in 2008 to validate high water temperatures, up to 35 C and evaluate the performance of surface temperature retrieval algorithms under wet and dry atmospheres depending on time of year.&amp;amp;#160;&amp;lt;br&amp;gt;Data from the sites have been used to validate numerous satellite instruments including the Advanced Very High Resolution Radiometer (AVHRR) series, the Along Track Scanning Radiometer (ATSR) series, the Advanced Spaceborne Thermal Emission and Reflectance Radiometer (ASTER), the Landsat series, the Moderate Resolution Imaging Spectroradiometer (MODIS) on both the Terra and Aqua platforms, the Visible Infrared Imaging Radiometer Suite (VIIRS) and the ECOsystem Spaceborne Thermal Radiometer Experiment on Space Station (ECOSTRESS). In all cases the standard products have been validated including the standard radiance at sensor, radiance at surface, surface temperature and surface emissivity products. We will present results from the validation of the mid and thermal infrared data from several of the aforementioned instruments and cross compare those results.&amp;lt;/p&amp;gt;&amp;lt;p&amp;gt;&amp;amp;#169; 2020 California Institute of Technology. Government sponsorship acknowledged.&amp;lt;/p&amp;gt;
Environmental Regulation of Pseudomonas aeruginosa PAO1 Las and Rhl Quorum-Sensing Systems (2007)

The lasI-lasR and the rhlI-rhlR quorum-sensing systems in Pseudomonas aeruginosa regulate the expression of numerous cellular and secreted virulence factor genes and play important roles in the development of biofilms. The las and rhl systems themselves are known to be directly or indirectly regulated by a number of transcriptional regulators, and consequently, their expression is sensitive to environmental conditions. In this report, the activities of these two quorum-sensing systems have been examined systematically under 46 growth conditions, and the regulation by environmental conditions has been investigated. The relative timing and strength of expression of these two systems varied significantly under different conditions, which contrasts with the notion of a preset hierarchy with these two systems in P. aeruginosa. Depending on the growth conditions, the correlation between each synthase and its cognate transcriptional regulator also varied, suggesting that the transcription of these genes independently allows for further fine tuning of each system. Finally, we observe that the activities of both the lasI-lasR and the rhlI-rhlR quorum-sensing systems were dramatically enhanced in the presence of extracts of sputum samples from cystic fibrosis patients.
Muscle Structural Capacity for Oxygen Flux from Capillary to Fiber Mitochondria (2002)

The concept of major functional resistance to O2 flux at the capillary-fiber interface implies that muscle structural capacity for O2 flux from capillary to fiber mitochondria needs to be assessed in terms of capillary surface per fiber surface. Morphological data support this notion and show the importance of assessing the size of the capillary-fiber interface relative to muscle fiber O2 demand.
Synthesis of 68Ga-Labeled Biopolymer-based Nanoparticle Imaging Agents for Positron-emission Tomography (2019)

In vivo results supporting the preliminary in vitro tests demonstrated considerably higher <sup>68</sup>Ga-NODAGA-FA nanoparticle accumulation in KB tumors than in MDA-MB-231 tumors, thereby confirming the folate receptor-mediated uptake of this novel potential PET imaging agent.
Human Bcl-2 Reverses Survival Defects in Yeast Lacking Superoxide Dismutase and Delays Death of Wild-Type Yeast (1997)

We expressed the human anti-apoptotic protein, Bcl-2, in Saccharomyces cerevisiae to investigate its effects on antioxidant protection and stationary phase survival. Yeast lacking copper-zinc superoxide dismutase (sod1Delta) show a profound defect in entry into and survival during stationary phase even under conditions optimal for survival of wild-type strains (incubation in water after stationary phase is reached). Expression of Bcl-2 in the sod1Delta strain caused a large improvement in viability at entry into stationary phase, as well as increased resistance to 100% oxygen and increased catalase activity. In addition, Bcl-2 expression reduced mutation frequency in both wild-type and sod1Delta strains. In another set of experiments, wild-type yeast incubated in expired minimal medium instead of water lost viability quickly; expression of Bcl-2 significantly delayed this stationary phase death. Our results demonstrate that Bcl-2 has activities in yeast that are similar to activities it is known to possess in mammalian cells: (a) stimulation of antioxidant protection and (b) delay of processes leading to cell death.
Unikernel monitors: extending minimalism outside of the box (2016)

Recently, unikernels have emerged as an exploration of minimalist software stacks to improve the security of applications in the cloud. In this paper, we propose extending the notion of minimalism beyond an individual virtual machine to include the underlying monitor and the interface it exposes. We propose unikernel monitors. Each unikernel is bundled with a tiny, specialized monitor that only contains what the unikernel needs both in terms of interface and implementation. Unikernel monitors improve isolation through minimal interfaces, reduce complexity, and boot unikernels quickly. Our initial prototype, ukvm, is less than 5% the code size of a traditional monitor, and boots MirageOS unikernels in as little as 10ms (8× faster than a traditional monitor).
Synthesis and Biological Screening of 2-Substituted 5,6-Dihydro-5-oxo- 4H-1,3,4-oxadiazine-4-propanenitriles and of Their Intermediates (2002)

To evaluate the effect of substituents on biological activities of electron-rich N-containing heterocycles, the variably 2-substituted 5,6-dihydro-5-oxo-4H-1,3,4-oxadiazine-4-propanenitriles 26–33 were synthesized and evaluated for antibacterial, antifungal, and enzyme-inhibition activities. The target compounds were obtained from alkyl 4- or 3-hydroxy benzoates 1 and 2, respectively, and from methyl indoleacetate 3. The phenolic OH group of benzoates 1 and 2 were substituted with p-toluenesulfonyl (→4 and 5), benzoyl (→6 and 7), and benzyl groups (→8 and 9) and then converted to 5,6-dihydro-5-oxo-4H-1,3,4-oxadiazine-4-propanenitriles. To establish structure-activity relationships (SAR), a pharmacological screening of the intervening intermediates was also conducted, which revealed that the intermediate hydrazide 11 possesses significant antimicrobial and MAO-A inhibiting properties and intermediates 12, 24, 28, and 29 appreciable antifungal activities. Compound 7 inhibits α-chymotrypsin.
Adverse Local Tissue Reaction Arising from Corrosion at the Femoral Neck-Body Junction in a Dual-Taper Stem with a Cobalt-Chromium Modular Neck (2013)

Corrosion at the modular neck-body junction in dual-tapered stems with a modular cobalt-chromium-alloy femoral neck can lead to release of metal ions and debris resulting in local soft-tissue destruction. Adverse local tissue reaction should be considered as a potential cause for new-onset pain in patients with these components, and early revision should be considered given the potentially destructive nature of these reactions. A workup including serologic studies (erythrocyte sedimentation rate and C-reactive protein), serum metal levels, and MARS MRI can be helpful in establishing this diagnosis.
Bench-to-bedside review: Rapid molecular diagnostics for bloodstream infection - a new frontier? (2012)

Among critically ill patients, the diagnosis of bloodstream infection poses a major challenge. Current standard bacterial identification based on blood culture platforms is intrinsically time-consuming and slow. The continuous evolvement of molecular techniques has the potential of providing a faster, more sensitive and direct identification of causative pathogens without prior need for cultivation. This may ultimately impact clinical decision-making and antimicrobial treatment. This review summarises the currently available technologies, their strengths and limitations and the obstacles that have to be overcome in order to develop a satisfactory bedside point-of-care diagnostic tool for detection of bloodstream infection.
An address generator of a pseudo-Hilbert scan in a rectangle region (2002)

The Hilbert curve is one of space filing curves presented by G. Peano in 1890. We apply this curve to scanning an arbitrary sized image for image compression, image processing, etc. In this paper, we propose a new, simple, non-recursive algorithm for pseudo-Hilbert scanning using lookup tables. The merit of our algorithm is that the computation is fast and the hardware implementation is much easier than previous ones. From our experimental results, we have confirmed that our method is about 50 times faster than other methods.
Fatty liver index, gamma-glutamyltransferase, and early carotid plaques (2012)

Our cross-sectional study suggests that subjects with FLI ≥60 are at higher risk of atherosclerotic lesions, independently of established risk factors, and that serum GGT may represent a link between fatty liver and the development of early atherosclerosis.
Crystal Structure of a Multidomain Human p53 Tetramer Bound to the Natural CDKN1A (p21) p53-Response Element (2011)

The p53 tumor suppressor protein is a sequence-specific DNA-binding transcription factor. Structures of p53 bound to DNA have been described, but, so far, no structure has been determined of p53 bound to a natural p53-response element. We describe here the structure of a human p53 homotetramer encompassing both the DNA-binding and homo-oligomerization domains in complex with the natural p53-response element present upstream of the promoter of the CDKN1A (p21) gene. Similar to our previously described structures of human p53 tetramers bound to an artificial consensus DNA site, p53 DNA binding proceeds via an induced fit mechanism with loops L1 of two subunits adopting recessed conformations. Interestingly, the conformational change involving loop L1 is even more extreme than the one previously observed with the artificial consensus DNA site. In fact, the previously determined loop L1 conformation seems to be a transition intermediate between the non-DNA-bound and CDKN1A-bound states. Thus, the new structure further supports our model that recognition of specific DNA by p53 is associated with conformational changes within the DNA-binding domain of p53.
Theory of gyro-backward wave oscillators with tapered magnetic field and waveguide cross section (1996)

A theory is developed which describes gyro-backward wave oscillators (gyro-BWO's) with arbitrarily relativistic electron beams and tapered external magnetic field and waveguide wall radius. For the case of linear tapering the optimal parameters are found that correspond to highly efficient operation. The frequency tunability as the function of magnetic field and voltage deviations has been analyzed. It is shown how to use the results given in terms of normalized parameters for designing concrete gyro-BWO's. For one concrete design the effect of electron velocity spread on the efficiency has been studied.
Large-Scale Characterization of the Murine Cardiac Proteome (2013)

Cardiomyopathies are diseases of the heart that result in impaired cardiac muscle function. This dysfunction can progress to an inability to supply blood to the body. Cardiovascular diseases play a large role in overall global morbidity. Investigating the protein changes in the heart during disease can uncover pathophysiological mechanisms and potential therapeutic targets. Establishing a global protein expression "footprint" can facilitate more targeted studies of diseases of the heart.In the technical review presented here, we present methods to elucidate the heart's proteome through subfractionation of the cellular compartments to reduce sample complexity and improve detection of lower abundant proteins during multidimensional protein identification technology analysis. Analysis of the cytosolic, microsomal, and mitochondrial subproteomes separately in order to characterize the murine cardiac proteome is advantageous by simplifying complex cardiac protein mixtures. In combination with bioinformatic analysis and genome correlation, large-scale protein changes can be identified at the cellular compartment level in this animal model.
Leveraging smart phones to reduce mobility footprints (2009)

Mobility footprint refers to the size, weight, and energy demand of the hardware that must be carried by a mobile user to be effective at any time and place. The ideal of a zero mobility footprint is achievable by encapsulating personal computing state in a virtual machine (VM) and delivering it over the Internet to a locally-obtained computer close to the user. In locations with poor Internet connectivity, the demands placed on WAN bandwidth can result in unacceptable user experience. We show how this challenge can be overcome by using nascent smart phone technology as a trusted personal assistant called Horatio that serves as a self-cleaning portable cache for VM state. Since most users already carry cell phones for voice calls and texting, Horatio does not increase the size or weight aspects of a user's mobility footprint - there is only a small increase in the energy aspect. We have built an experimental prototype of Horatio, and measurements confirm its ability to improve user experience even with current smart phone limitations.
Microfluidic approaches for cancer cell detection, characterization, and separation (2012)

This article reviews the recent developments in microfluidic technologies for in vitro cancer diagnosis. We summarize the working principles and experimental results of key microfluidic platforms for cancer cell detection, characterization, and separation based on cell-affinity micro-chromatography, magnetic activated micro-sorting, and cellular biophysics (e.g., cell size and mechanical and electrical properties). We examine the advantages and limitations of each technique and discuss future research opportunities for improving device throughput and purity, and for enabling on-chip analysis of captured cancer cells.