gebhart/patrepeval huggingface dataset:
2-DOF Control of a Fire-Rescue Turntable Ladder (2011)

Modern fire-rescue turntable ladders are build to be in lightweight of construction to increase their maximum operation velocities, maximum length, and outreach. Hence, the truss structure of the ladder set provides a limited stiffness and is subject to bending oscillations in the various modes. To damp these oscillations with its hydraulic drives, a 2-degree-of-freedom control is proposed in this paper. The feedforward control is based on the differential flatness of a simple multibody system by only considering the fundamental oscillations. Using Euler-Bernoulli beam theory, the dominant modes of oscillation are taken into account during feedback control design. The model parameters are assumed discontinuous but piecewise constant over the ladder length while the cage at the free end is accounted for by dynamic boundary conditions. Based on the analytical form of the eigenfunctions the modal representation of the system is derived. It is used to design a feedback controller and to merge the measurement information of the gyroscope with the measurements of the strain gauges. The proposed control approach allows for damping of the dominant modes and for asymptotically stabilizing the system around a reference trajectory. An important demand on the proposed approach is to derive a control law which accounts for the low computational power of the ladder's microcontroller. The proposed control concept is implemented in fixed-point arithmetic on the control unit running the turntable ladders made by the market leader IVECO Magirus Brandschutztechnik GmbH. Measurement results from the IVECO Magirus DLK55CS validate the performance of the proposed control concept on a ladder already in production.
BSIM4-based lateral diode model for LNA co-designed with ESD protection circuit (2010)

POLY gate defined lateral ESD diodes were fabricated, characterized and modeled using Foundry standard 65nm CMOS technology. Compare to conventional STI diode, the lateral diode demonstrated superior Q-factor and TLP IT2 due to the reduced transport distance and RC constant. Aided by BSIM4 MOS transistor model, a physically based scalable lateral diode model was developed and presented here for the first time. The accuracy of the diode model was validated with RF characterization data over a broad device geometrical range. The model was successfully used in LNA and ESD CDM protection co-design. A good match of LNA RF performance between Si-data and model prediction was achieved. Experimental results showed that LNA with Lateral Diode protection passed +/−500V ESD CDM zap voltage, while LNA with STI diode started to fail at only −250V.
Characteristic Male Urine Microbiomes Associate with Asymptomatic Sexually Transmitted Infection (2010)

Urine microbiomes from men with STI were dominated by fastidious, anaerobic and uncultivated bacteria. The same taxa were rare in STI negative individuals. Our findings suggest that the composition of male urine microbiomes is related to STI.
Variabilité intra-individuelle des activités opératoires et dépendance-indépendance à l'égard du champ (1982)

Ohlmann Théophile, Mendelsohn P. Variabilité intra-individuelle des activités opératoires et dépendance-indépendance à l'égard du champ. In: L'année psychologique. 1982 vol. 82, n°1. pp. 131-154.
Comparison of Aptamer Signaling Mechanisms Reveals Disparities in Sensor Response and Strategies to Eliminate False Signals (2023)

Aptamers are nucleic acid-based affinity reagents that have been incorporated into a variety of molecular sensor formats. However, many aptamer sensors exhibit insufficient sensitivity and specificity for real-world applications, and although considerable effort has been dedicated to improving sensitivity, sensor specificity has remained largely neglected and understudied. In this work, we have developed a series of sensors using aptamers for the small-molecule drugs flunixin, fentanyl, and furanyl fentanyl and compare their performance─in particular, focusing on their specificity. Contrary to expectations, we observe that sensors using the same aptamer operating under the same physicochemical conditions produce divergent responses to interferents depending on their signal transduction mechanism. For instance, aptamer beacon sensors are susceptible to false-positives from interferents that weakly associate with DNA, while strand-displacement sensors suffer from false-negatives due to interferent-associated signal suppression when both the target and interferent are present. Biophysical analyses suggest that these effects arise from aptamer-interferent interactions that are either nonspecific or induce aptamer conformational changes that are distinct from those induced by true target-binding events. We also demonstrate strategies for improving the sensitivity and specificity of aptamer sensors with the development of a "hybrid beacon," wherein the incorporation of a complementary DNA competitor into an aptamer beacon selectively hinders interferent─but not target─binding and signaling, while simultaneously overcoming signal suppression by interferents. Our results highlight the need for systematic and thorough testing of aptamer sensor response and new aptamer selection methods that optimize specificity more effectively than traditional counter-SELEX.
Original Article : Acute Renal Failure Following Off-pump Coronary Artery Bypass Surgery (OPCAB): Incidence, Risk Factors, and Outcomes (2007)

Purpose : Off-pump coronary artery bypass (OPCAB) is known to be associated with a lower risk acute renal failure (ARF) than on-pump method. However, little data is available on ARF in OPCAB. The aim of the present study was to identify the incidence, risk factors, and mortality of ARF OPCAB. Methods : Perioperative variables in medical records of 573 patients who had undergone OPCAB from Jan 2000 to June 2004 were evaluated. ARF was defined as a 50% increase in preoperative serum creatinine (over 1.4 mg/dL) within 72 hours after operation, or as the need for postoperative dialysis. Results : The incidence of ARF and ARF requiring dialysis were 9.8% and 2.6%, respectively. The independent risk factors for ARF after OPCAB were the perioperative use of an intra-aortic balloon pump (OR, 4.425; 95% CI, 2.342-8.403), high preoperative serum creatinine (OR 2.099; 95% CI, 1.422-3.098), diabetes (OR, 1.961; 95% CI, 1.078-3.571), and old age (OR, 1.479; 95% CI, 1.034-2.116). The in-hospital mortality rate was 53.3% for patients requiring dialysis, 19.6% for all ARF patients and 0.8% for patients without ARF (p<0.001). The 3-year cumulative mortality rate was 38.4 in all ARF patients and 5.2% in patients without ARF (p<0.001).
Conclusion : ARF was not an uncommon complication in adults who underwent OPCAB. Perioperative hemodynamic instability, preoperative renal dysfunction, diabetes, and age could independently predict the development of ARF after OPCAB and the severity of ARF was related to higher in-hospital and long-term mortality rates.
Changes in Renin Content in Kidneys of Renal Hypertensive Rats (1962)

SummaryThe renin content of fresh kidney tissue was assayed indirectly by a modification of Schaffenburg's method(3) in rats with experimental renal hypertension, under a variety of conditions. Clamping one renal artery caused an increased concentration of renin in the clamped kidney, and a fall in the contralateral kidney. Clamping both renal arteries also caused an increase in renin content of the more efficiently clamped kidney and a decrease in the contralateral kidney. Renin content in the one remaining kidney was not influenced by unilateral nephrectomy in normal rats. Clamping the one remaining renal artery in unilaterally nephrectomized rats induced hypertension, but did not result in an increase in renin content of the kidney. Similarly, removal of the undamped kidney in rats with hypertension due to a unilateral renal artery clip resulted in a slow decrease of renin content in the clamped kidney to normal values. Removal of the clamped kidney in such animals caused a rapid fall of blood pressure and a subsequent slow increase of renin content in the remaining undamped kidney. A unifying hypothesis to explain these changes is presented, involving a concept of renin inhibition or inactivation.
A Single Dose of a MIV-150/Zinc Acetate Gel Provides 24 h of Protection Against Vaginal Simian Human Immunodeficiency Virus Reverse Transcriptase Infection, with More Limited Protection Rectally 8–24 h After Gel Use (2012)

Previously we showed that repeated vaginal application of a MIV-150/zinc acetate carrageenan (MIV-150/ZA/CG) gel and a zinc acetate carrageenan (ZA/CG) gel significantly protected macaques from vaginal simian human immunodeficiency virus reverse transcriptase (SHIV-RT) infection. Gels were applied either daily for 2 weeks or every other day for 4 weeks, and the animals were challenged 4-24 h later. Herein, we examined the effects of a single vaginal dose administered either before or after virus challenge. Encouraged by the vaginal protection seen with MIV-150/ZA/CG, we also tested it rectally. Vaginal applications of MIV-150/ZA/CG, ZA/CG, and CG gel were performed once 8-24 h before, 1 h after, or 24 h before and 1 h after vaginal challenge. Rectal applications of MIV-150/ZA/CG and CG gel were performed once 8 or 24 h before rectal challenge. While vaginal pre-challenge and pre/post-challenge application of MIV-150/ZA/CG gel offered significant protection (88%, p<0.002), post-challenge application alone did not significantly protect. ZA/CG gel reduced infection prechallenge, but not significantly, and the effect was completely lost post-challenge. Rectal application of MIV-150/ZA/CG gel afforded limited protection against rectal challenge when applied 8-24 h before challenge. Thus, MIV-150/ZA/CG gel is a highly effective vaginal microbicide that demonstrates 24 h of protection from vaginal infection and may demonstrate efficacy against rectal infection when given close to the time of HIV exposure.
Modelling the layer-specific three-dimensional residual stresses in arteries, with an application to the human aorta (2009)

This paper provides the first analysis of the three-dimensional state of residual stress and stretch in an artery wall consisting of three layers (intima, media and adventitia), modelled as a circular cylindrical tube. The analysis is based on experimental results on human aortas with non-atherosclerotic intimal thickening documented in a recent paper by Holzapfel et al. (Holzapfel et al. 2007 Ann. Biomed. Eng. 35, 530-545 (doi:10.1007/s10439-006-9252-z)). The intima is included in the analysis because it has significant thickness and load-bearing capacity, unlike in a young, healthy human aorta. The mathematical model takes account of bending and stretching in both the circumferential and axial directions in each layer of the wall. Previous analysis of residual stress was essentially based on a simple application of the opening-angle method, which cannot accommodate the three-dimensional residual stretch and stress states observed in experiments. The geometry and nonlinear kinematics of the intima, media and adventitia are derived and the associated stress components determined explicitly using the nonlinear theory of elasticity. The theoretical results are then combined with the mean numerical values of the geometrical parameters and material constants from the experiments to illustrate the three-dimensional distributions of the stretches and stresses throughout the wall. The results highlight the compressive nature of the circumferential stress in the intima, which may be associated with buckling of the intima and its delamination from the media, and show that the qualitative features of the stretch and stress distributions in the media and adventitia are unaffected by the presence or absence of the intima. The circumferential residual stress in the intima increases significantly as the associated residual deformation in the intima increases while the corresponding stress in the media (which is compressive at its inner boundary and tensile at its outer boundary) is only slightly affected. The theoretical framework developed herein enables the state of residual stress to be calculated directly, serves to improve insight into the mechanical response of an unloaded artery wall and can be extended to accommodate more general geometries, kinematics and states of residual stress as well as more general constitutive models.
Sweet and bitter taste discrimination and energy requirements in non-human primates. (1995)

International audience
Data from The Effect of Different Linkers on Target Cell Catabolism and Pharmacokinetics/Pharmacodynamics of Trastuzumab Maytansinoid Conjugates (2023)

&lt;div&gt;Abstract&lt;p&gt;Trastuzumab emtansine (T-DM1) is an antibody–drug conjugate consisting of the anti-HER2 antibody trastuzumab linked via a nonreducible thioether linker to the maytansinoid antitubulin agent DM1. T-DM1 has shown favorable safety and efficacy in patients with HER2-positive metastatic breast cancer. In previous animal studies, T-DM1 exhibited better pharmacokinetics (PK) and slightly more efficacy than several disulfide-linked versions. The efficacy findings are unique, as other disulfide-linked antibody–drug conjugates (ADC) have shown greater efficacy than thioether-linked designs. To explore this further, the &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt; activity, PK, and target cell activation of T-DM1 and the disulfide-linked T-SPP-DM1 were examined. Both ADCs showed high &lt;i&gt;in vitro&lt;/i&gt; potency, with T-DM1 displaying greater potency in two of four breast cancer cell lines. &lt;i&gt;In vitro&lt;/i&gt; target cell processing of T-DM1 and T-SPP-DM1 produced lysine-&lt;i&gt;N&lt;sup&gt;ϵ&lt;/sup&gt;&lt;/i&gt;-MCC-DM1, and lysine-&lt;i&gt;N&lt;sup&gt;ϵ&lt;/sup&gt;&lt;/i&gt;-SPP-DM1 and DM1, respectively; &lt;i&gt;in vivo&lt;/i&gt; studies confirmed these results. The &lt;i&gt;in vitro&lt;/i&gt; processing rates for the two conjugate to their respective catabolites were similar. &lt;i&gt;In vivo&lt;/i&gt;, the potencies of the conjugates were similar, and T-SPP-DM1 had a faster plasma clearance than T-DM1. Slower T-DM1 clearance translated to higher overall tumor concentrations (conjugate plus catabolites), but unexpectedly, similar levels of tumor catabolite. These results indicate that, although the ADC linker can have clear impact on the PK and the chemical nature of the catabolites formed, both linkers seem to offer the same payload delivery to the tumor. &lt;i&gt;Mol Cancer Ther; 11(5); 1133–42. ©2012 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
UV Resonance Raman Investigation of the Aqueous Solvation Dependence of Primary Amide Vibrations (2015)

We investigated the normal mode composition and the aqueous solvation dependence of the primary amide vibrations of propanamide. Infrared, normal Raman, and UV resonance Raman (UVRR) spectroscopy were applied in conjunction with density functional theory (DFT) to assign the vibrations of crystalline propanamide. We examined the aqueous solvation dependence of the primary amide UVRR bands by measuring spectra in different acetonitrile/water mixtures. As previously observed in the UVRR spectra of N-methylacetamide, all of the resonance enhanced primary amide bands, except for the Amide I (AmI), show increased UVRR cross sections as the solvent becomes water-rich. These spectral trends are rationalized by a model wherein the hydrogen bonding and the high dielectric constant of water stabilizes the ground state dipolar (-)O-C═NH2(+) resonance structure over the neutral O═C-NH2 resonance structure. Thus, vibrations with large C-N stretching show increased UVRR cross sections because the C-N displacement between the electronic ground and excited state increases along the C-N bond. In contrast, vibrations dominated by C═O stretching, such as the AmI, show a decreased displacement between the electronic ground and excited state, which result in a decreased UVRR cross section upon aqueous solvation. The UVRR primary amide vibrations can be used as sensitive spectroscopic markers to study the local dielectric constant and hydrogen bonding environments of the primary amide side chains of glutamine (Gln) and asparagine (Asn).
Nanophotonic Devices Based on Indium Phosphide Nanopillars Grown Directly on Silicon (2017)

III-V optoelectronic device integration in a CMOS post-process compatible manner is important for the intimate integration of silicon-based electronic and photonic integrated circuits. The low temperature, self-catalyzed growth of high crystalline quality Wurtzite-phase InP nanopillars directly on silicon presents a viable approach to integrate high performance nano-optoelectronic devices.For the optical transmitter side of the photonic link, InGaAs quantum wells have been grown in a core-shell manner within InP nanopillars. Position-controlled growth with varying pitch is used to systematically control emission wavelength across the same growth substrate. These nanopillars have been fabricated into electrically-injected quantum well in nanopillar LEDs operating within the silicon transparent 1400-1550 nm spectral window and efficiently emitting micro-watts of power. A high quality factor (Q ~ 1000) undercut cavity quantum well nanolaser is demonstrated, operating in the silicon-transparent wavelength range up to room temperature under optical excitation.We also demonstrate an InP nanopillar phototransistor as a sensitive, low-capacitance photoreceiver for the energy-efficient operation of a complete optical link. Efficient absorption in a compact single nanopillar InP photo-BJT leads to a simultaneously high responsivity of 9.5 A/W and high 3dB-bandwidth of 7 GHz.For photovoltaic energy harvesting, a sparsely packed InP nanopillar array can absorb ~90% of the incident light because of the large absorption cross section of these near-wavelength nanopillars. Experimental data based on wavelength and angle resolved integrating sphere measurements will be presented to discuss the nearly omnidirectional absorption properties of these nanopillar arrays.
The Emperor's New Password Manager: Security Analysis of Web-based Password Managers (2014)

We conduct a security analysis of five popular web-based password managers.Unlike "local" password managers, web-based password managers run in the browser.We identify four key security concerns for web-based password managers and, for each, identify representative vulnerabilities through our case studies.Our attacks are severe: in four out of the five password managers we studied, an attacker can learn a user's credentials for arbitrary websites.We find vulnerabilities in diverse features like one-time passwords, bookmarklets, and shared passwords.The root-causes of the vulnerabilities are also diverse: ranging from logic and authorization mistakes to misunderstandings about the web security model, in addition to the typical vulnerabilities like CSRF and XSS.Our study suggests that it remains to be a challenge for the password managers to be secure; password managers, in their current form, may not provide sufficient security for user secrets.To guide future development of password managers, we provide guidance for password managers.Given the diversity of vulnerabilities we identified, we advocate a defense-in-depth approach to ensure security of password managers.
<title>Micromachined electron source</title> (1992)

A new microfabrication technique that allows the precise construction of large three dimensional structures with dimensional tolerances approaching 1 micron is being applied to the design of a Miniature Scanning Electron Microscope (MSEM). In this paper we will present the electron optic calculations of the MSEM source (gun). The MSEM measures less than one cubic centimeter and the source measures approximately lx I xO.20 cm3. The details of the MSEM fabrication are in an accompanying article.1
ChemInform Abstract: Optically Active 2,3‐Allenoates via Palladium‐Catalyzed Carbonylation of Enantioenriched Propargylic Mesylates. (2013)

Abstract The reaction allows to introduce various alkyl‐, allyl‐ and benzyl substituents in the desired optically active allene derivatives.
3405 Nano-motion Stage for Scan Recording (2007)

A highly precise actuator which applied to a track following for a high density magnetic recording evaluation system was designed and developed. The actuator called the Nano-motion actuator (NMA) that was consisted of a displacement amplitude mechanism, which was composed of a parallel spring and a lever mechanism, a layered piezoelectric element (PZT). A original NMA has a working distance of 12.5m and the gain crossover frequency of 4.92kHz. The Nano-motion Stage (NMS) that composed of the original NMA and a new translation type of NMA was designed for new scan recoding. In this paper, we evaluted the positioning accuracy of the Nano-motion Stage in a X-Y plane by using lissajous circle and step responses for each axis. As the results, the gain crossover frequency could be reached over 1.6kHz for X and Y axis by PID controller, respectively. However large overshoots and influences of another axis were occured each other, if the overshoots design under 20% of desired value not decreasing,a new controller other than the PID should requiered for the NMS.
Echo: An Edge-Centric Code Offloading System With Quality of Service Guarantee (2018)

Code offloading is a promising way to accelerate mobile applications and reduce the energy consumption of mobile devices by shifting some computation to the cloud. However, existing code offloading systems suffer from a long communication delay between mobile devices and the cloud. To address this challenge, in this paper, we consider to deploy edge nodes in close proximity to mobile devices and study how they benefit code offloading. We design an edge-centric code offloading system, called Echo, over a three-layer computing hierarchy consisting of mobile devices, the edge, and the cloud. A critical problem needs to be addressed by Echo is to decide which methods should be offloaded to which computing platform (the edge or the cloud). Different from existing offloading systems that let mobile devices individually make offloading decisions, Echo implements a centralized decision engine at the edge. This edge-centric design can fully exploit limited hardware resources at the edge to provide offloading services with the quality-of-service guarantee. Furthermore, we propose some novel mechanisms, e.g., lazy object transmission and differential object update, to further improve system performance. The results of a small-scale real deployment and trace-driven simulations show that Echo significantly outperforms existing code offloading systems at both execution time and energy consumption.
A review of image-warping methods (1998)

Image war ping is a transformation which maps all positions in one image plane to positions in a second plane. It arises in many image analysis problems, whether in order to remove optical distortions introduced by a camera or a particular viewing perspective, to register an image with a map or template, or to align two or more images. The choice of war p is a compromise between a smooth distortion and one which achieves a good match. Smoothness can be ensured by assuming a parametric for m for the warp or by constraining it using diOE erential equations. Matching can be speci ed by points to be brought into alignment, by local measures of correlation between images, or by the coincidence of edges. Parametric and non-parametric approaches to war ping, and matching criteria, are reviewed.
Iontophoresis: noninvasive drug delivery. (1998)

Iontophoresis allows for the transdermal delivery of charged drugs under the influence of a low-level electric current. Recently iontophoretic technology has been used to deliver lidocaine to provide rapid, noninvasive local anesthesia. Studies have also demonstrated the ability to obtain systemic opiate levels using this technology. In this article we review the history and principles of iontophoresis as well as the literature supporting its use for both local anesthesia and systemic analgesia.