gebhart/patrepeval huggingface dataset:
Virus-like particles as vaccine. (2014)

This review presents data on commercial and experimental virus-like particle (VLP) vaccines, including description of VLP vaccines against influenza. Virus-like particles are multimeric, sometimes multiprotein nanostructures assembled from viral structural proteins and are devoid of any genetic material. VLPs present repetitive high-density displays of viral surface proteins. Importantly, they contain functional viral proteins responsible for cell penetration by the virus, ensuring efficient cell entry and thus tissue-specific targeting, determined by the origin of the virus. The foremost application of VLPs is in vaccinology, where they provide delivery systems that combine good safety profiles with strong immunogenicity and constitute a safe alternative to inactivated infectious viruses. These stable and versatile nanoparticles display excellent adjuvant properties capable of inducing innate and cognate immune responses. They present both, high-density B-cell epitopes, for antibody production and intracellular T-cell epitopes, thus inducing, respectively, potent humoral and cellular immune responses. Uptake of VLPs by antigen-presenting cells leads to efficient immune responses resulting in control of pathogenic microorganisms.
Speech-music discrimination from MPEG-1 bitstream (2001)

Abstract: This paper describes a proposed algorithm for speech/music discrimination, which works on data directly taken from MPEG encoded bitstream thus avoiding the computationally difficult decoding-encoding process. The method is based on thresholding of features derived from the modulation envelope of the frequency-limited audio signal. The discriminator is tested on more than 2 hours of audio data, which contain clean and noisy speech from several speakers and a variety of music content. The discriminator is able to work in real time and despite its simplicity, results are very promising.
Fluorescent markers for hypoxic cells: a study of nitroaromatic compounds, with fluorescent heterocyclic side chains, that undergo bioreductive binding (1991)

Several novel compounds having both a 2-nitroimidazole nucleus and a fluorescent ring system in their molecular structure were prepared and evaluated as potential fluorescent probes for hypoxia. Bioreduction of nitroimidazoles, which is inhibited by oxygen, is known to lead to binding of bioreductive metabolites to cellular macromolecules and this provides a mechanism for binding the fluorescent moiety to hypoxic cells. These compounds can incorporate a wide range of fluorophors and can therefore be designed to suit the laser-line wavelengths available for excitation of fluorescence in the flow cytometer. Several nitroimidazoles with naphthalimide side chains were rapidly taken up into cells and became concentrated in the cells, thus reducing their concentration in the extracellular medium. This suggests a potential microscopic bioavailability problem with probes of this type when used in vivo as they would become progressively depleted in the extracellular fluid as they diffused from blood vessels, through layers of packed cells in tumors, to the hypoxic cells where they could undergo hypoxia-specific metabolism. Synthesis of nitroimidazoles with coumarin fluorophors led to several potentially useful probes for hypoxia; substituents on the coumarin fluorophor had a marked effect on the cellular fluorescence of these compounds.
RF-field interactions with biological systems: Electrical properties and biophysical mechanisms (1980)

Electrical properties of tissues, macromolecular solutions, and cell membranes are summarized at frequencies from the extra low frequency (ELF) to microwave range. Previously presented dielectric data are supplemented by new results and a more detailed discussion of the physical mechanisms for the observed temperature coefficients of the dielectric properties. The dielectric data are discussed in terms of the interaction mechanisms which give rise to observed relaxational effects. Possible mechanisms for nonthermal weak interactions between radio-frequency (RF) energy and tissues are discussed and evaluated.
Large-mode-area single-mode microstructured optical fibre for the mid-IR region (2009)

A single-mode microstructured optical fibre is fabricated from silver halogenide crystals. The fibre is intended for the mid-IR region and features a large mode area (13600 μm2). It is shown experimentally and theoretically that the fibre is in fact single-mode at 10.6 μm and has an optical loss of 8 dB m−1.
PaperWeb (2013)

While mobile phones have penetrated deep into tier 2 and 3 cities in India and similar emerging economies, adoption of mobile web content and web services is likely to require the creation of large numbers of relevant applications and services with usable interfaces and interaction paradigms. This paper describes PaperWeb, our effort to enable mobile phone users to use the web for day to day transactions such as paying bills, buying tickets, or fixing appointments, using familiar objects such as paper artifacts. We discuss (i) the creation of useful PaperWeb interactions -- without programming -- by moderately tech-savvy users, and (ii) the use of these interactions by tech-naive users, and briefly describe the underlying technology. We conclude the paper with a discussion of current status and next steps.
Pushing conventional SiGe HBT technology towards 'dotfive' terahertz (2010)

This paper presents an overview of the millimeter-wave dedicated 130nm SiGe BiCMOS technology used by STMicroelectronics as a starting point for DOTFIVE Project developments, and achievements during the first two years of the Project, which culminate in the demonstration of an intermediate 400GHz f MAX SiGe HBT process, with good device control and reproducibility.
Withdrawal: Quantitative Synthesis of Temperature‐responsive Polymersomes by Multiblock Polymerization (2019)

This Communication, published online on 14 August 2019 in Wiley Online Library (onlinelibrary.wiley.com), has been withdrawn by agreement between the corresponding authors, the journal's Executive Committee, and Wiley‐VCH GmbH, Weinheim. The withdrawal has been agreed upon following the explanation by the authors that problems with a microscopy image presented in Figure 4 of the article cannot be fully clarified.
DESIGN AND ANALYSIS OF NEW COMPACT UWB FREQUENCY SELECTIVE SURFACE AND ITS EQUIVALENT CIRCUIT (2014)

A compact, low proflle, dual polarized, ultra wideband, frequency selective surface is proposed. It is designed by using two similar metallic array structures separated by dielectric material FR4. The simulated re∞ection bandwidth (with transmission < i20dB) for TE incident wave is 8GHz from 2.87GHz to 10.87GHz corresponds to 116%. The unit cell dimension and periodicity are of the order of 0:37‚ at the centre frequency. The overall thickness of the proposed FSS is 1.8mm. The proposed FSS has higher order of band-stop response and good angular stability. The measured transmission response of FSS is very close to simulated response. Design expressions for the resonance frequencies are proposed, and the calculated results are found to be in good agreement with the simulated ones. Finally, a parametric analysis of the proposed FSS is presented.
Nanostructuring a Zr-Hf Alloy via Large Strain Rolling (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Prevention of Subsequent Catheter‐Related Bloodstream Infection Using Catheter Locks in High‐Risk Patients Receiving Home Parenteral Nutrition (2015)

The major findings of the present study reveal that ALT or ELT can reduce the overall rate of infections per 1000 catheter days. ALT or ELT can be used in appropriate clinical setting for patients receiving HPN.
The Icarus Flight of Perinatal Stem and Renal Progenitor Cells Within Immune System (2022)

Our immune system actively fights bacteria and viruses, and it must strike a delicate balance between over- and under-reaction, just like Daedalus and Icarus in Greek mythology, who could not escape their imprisonment by flying too high or too low. Both human amniotic epithelial and mesenchymal stromal cells and the conditioned medium generated from their culture exert multiple immunosuppressive activities. They have strong immunomodulatory properties that are influenced by the types and intensity of inflammatory stimuli present in the microenvironment. Notably, very recently, the immunomodulatory activity of human adult renal stem/progenitor cells (ARPCs) has been discovered. ARPCs cause a decrease in Tregs and CD3<sup>+</sup> CD4<sup>-</sup> CD8<sup>-</sup> (DN) T cells in the early stages of inflammation, encouraging inflammation, and an increase in the late stages of inflammation, favoring inflammation quenching. If the inflammatory trigger continues, however, ARPCs cause a further increase in DN T cells to avoid the development of a harmful inflammatory state. As in the flight of Daedalus and Icarus, who could not fly too high or too low to not destroy their wings by the heat of the sun or the humidity of the sea, in response to an inflammatory environment, stem cells seem to behave by paying attention to regulating T cells in the balance between immune tolerance and autoimmunity. Recognizing the existence of both suppressive and stimulatory properties, and the mechanisms that underpin the duality of immune reaction, will aid in the development of active immunotherapeutic approaches that manipulate the immune system to achieve therapeutic benefit.
Alterations in Retinal Tyrosine and Dopamine Levels in Rats Consuming Protein or Tyrosine‐Supplemented Diets (1988)

The ad libitum ingestion of casein diets varying in protein content altered serum and retinal levels of tyrosine. The serum tyrosine level rose when protein ingestion was increased from 6 to 24% casein. In rats consuming high-protein diets (40% casein), no further increase in serum tyrosine level occurred, although the levels of other large neutral amino acids, which compete with tyrosine for retinal uptake, continued to rise. The activity of the liver enzyme tyrosine aminotransferase varied directly with the percentage of protein in the diet and may partially explain the failure of chronic high-protein feeding to increase serum tyrosine levels. The retinal tyrosine concentration was significantly correlated with the serum tyrosine level and with the serum tyrosine ratio at all levels of protein intake. Retinal 3,4-dihydroxyphenylalanine synthesis and dopamine (DA) level varied in parallel with the level of the precursor, tyrosine. Addition of pure L-tyrosine (1, 2, or 4%) to normal protein diets resulted in a stepwise increase in serum and retinal tyrosine levels and retinal DA turnover. Alterations of retinal tyrosine level as a result of change in amount of dietary protein or by its addition to the normal diet can influence retinal DA synthesis and release.
MIS approaches in the cervical spine (2019)

Minimally invasive surgical approaches for the treatment of spinal pathologies have accelerated over the past three decades and resulted in superior functional outcomes with less complications. Yet cervical pathologies have been slower to gain traction for multiple anatomical factors and its "high-risk" profile. Various minimally invasive techniques for cervical disease have now been described and validated in long-term studies with comparable outcomes to traditional open approaches and concomitant reduction in morbidity and socioeconomic costs. Transnasal operations can be used to treat ventral upper cervical disease, circumventing traditional and morbid transoral approaches. Posterior-based focused treatments for radiculopathy and myelopathy such as tubular-guided foraminotomies and unilateral laminotomies for bilateral cord decompression have also been described and becoming increasingly less invasive. Cervical fusions can now be performed percutaneously through modified, stand-alone facet joint cages that can be packed with allogeneic bone graft. These advances have been facilitated by the development of intraoperative imaging technologies (intraoperative CT) and 3-dimensional stereotactic navigation software. While this review focuses on these procedures and evidence-based outcomes data, the future for MIS applications in cervical spine surgery will continue to evolve over the coming years with wider indications and technological adjuncts.
Design and Synthesis of a Series of Potent and Orally Bioavailable Noncovalent Thrombin Inhibitors That Utilize Nonbasic Groups in the P1 Position (1998)

As part of an ongoing effort to prepare therapeutically useful orally active thrombin inhibitors, we have synthesized a series of compounds that utilize nonbasic groups in the P1 position. The work is based on our previously reported lead structure, compound 1, which was discovered via a resin-based approach to varying P1. By minimizing the size and lipophilicity of the P3 group and by incorporating hydrogen-bonding groups on the N-terminus or on the 2-position of the P1 aromatic ring, we have prepared a number of derivatives in this series that exhibit subnanomolar enzyme potency combined with good in vivo antithrombotic and bioavailability profiles. The oxyacetic amide compound 14b exhibited the best overall profile of in vitro and in vivo activity, and crystallographic studies indicate a unique mode of binding in the thrombin active site.
Single-shot tomographic microscopy for fast 3D cellular imaging (2021)

We propose a single-shot 3D cell imaging method with unprecedented sub-millisecond temporal resolution and diffraction-limited spatial resolution. This method is based on an angle-multiplexed illumination interferometric imaging system and a deep-learning 3D image reconstruction model.
Current Advances in Aptamers for Cancer Diagnosis and Therapy (2018)

Nucleic acid aptamers are single-stranded oligonucleotides that interact with target molecules with high affinity and specificity in unique three-dimensional structures. Aptamers are generally isolated by a simple selection process called systematic evolution of ligands by exponential enrichment (SELEX) and then can be chemically synthesized and modified. Because of their high affinity and specificity, aptamers are promising agents for biomarker discovery, as well as cancer diagnosis and therapy. In this review, we present recent progress and challenges in aptamer and SELEX technology and highlight some representative applications of aptamers in cancer therapy.
yMGV: a cross-species expression data mining tool (2003)

The yeast Microarray Global Viewer (yMGV @ http://transcriptome.ens.fr/ymgv) was created 3 years ago as a database that houses a collection of Saccharomyces cerevisiae and Schizosaccharo myces pombe microarray data sets published in 82 different articles. yMGV couples data mining tools with a user-friendly web interface so that, with a few mouse clicks, one can identify the conditions that affect the expression of a gene or list of genes regulated in a set of experiments. One of the major new features we present here is a set of tools that allows for inter-organism comparisons. This should enable the fission yeast community to take advantage of the large amount of available information on budding yeast transcriptome. New tools and ongoing developments are also presented here.
College Admissions and the Stability of Marriage (1962)

(2013). College Admissions and the Stability of Marriage. The American Mathematical Monthly: Vol. 120, No. 5, pp. 386-391.
PHOSPHORUS LEACHING THROUGH INTACT SOIL COLUMNS BEFORE AND AFTER POULTRY MANURE APPLICATION (2005)

Recent application of manure can increase phosphorus (P) loss from soil in subsurface flow (e.g., drainage water). This study investigated vertical leaching of P through two soils. Eight 30- and 50-cm-deep, intact soil columns (30-cm diameter) were collected. Columns were irrigated periodically (2.4 cm day−1) before and after surface application of poultry manure (85 kg total P ha−1), continuing for 11 weeks after the application. A dye tracer (FD&C blue No. 1) was used to identify the presence of active macropores at the bottom of each column, and to compare properties of undyed soil matrix material with dyed soil bordering active macropores. Before manure application, concentrations of total P (TP) in leachate did not exceed 0.57 mg L−1, with dissolved reactive P (DRP) a minor fraction of leachate TP (averaging 7%). Manure application resulted in significant increases in leachate P concentrations, with DRP averaging 72%of leachate TP. No significant differences in leachate DRP and TP concentrations were observed between 30- and 50-cm-deep columns or between soils, either before or after manure was applied, reflecting considerable variability in leachate P trends. In many columns, P concentrations in leachate peaked soon after manure application, with maximum DRP concentrations ranging from 1.1 to 11.2 mg L−1. In other columns, concentrations increased slowly over time, but maximum DRP concentrations were only 0.19 to 0.55 mg L−1. Different temporal trends in leachate P concentrations were unrelated to trends in flow. Increased P sorption saturation of soil bordering macropores in subsurface horizons, due to elevated Mehlich-3 P and depleted Mehlich-3 Al, points to the importance of macropores as preferential flow pathways for P. Results of this study highlight the significant, but temporally and spatially variable, nature of P leaching in manured soils.
Determination of platinum in the environmental samples by graphite furnace atomic absorption spectrophotometry. (1982)

Graphite furnace atomic absorption spectrophotometry(GFAAS) of platinum in urban air and automobile exhaust gas, as well as in biological samples has been studied. Pollution samples collected through a glass fiber filter were treated with aqua regia and the solution was then evaporated to dryness. The residue was dissolved in 3M hydrochloric acid and tin(II) chloride solution was added. The platinum-tin complex formed was extracted with isoamyl acetate(IA) and the extract was centrifuged. Platinum in the IA extract was measured by means of GFAAS. The present method is reproducible and any disturbance has not been observed. The calibration curve was linear in the range of 0.02-0.2 ppm platinum in the solution and the limit of identification was 0.01 ppm platinum.
Strategic Supply Chain Design for a New Market Opportunity from Qualified Partner Sets (2002)

This paper addresses the problem of supply chain design at the strategic level when production/distribution of a new market opportunity has to be launched among a set of qualified partners. The new market opportunity is characterized by a deterministic forecast over a planning horizon. The product (or service) is assumed to be produced (or provided) in a fixed sequence of some distinct stages or echelons, and each stage could have a number of qualified partners. The qualified partners at each stage might be different factories (or service organization) of the same corporation or different organizations that have agreed to participate in an open supply web. We assume that the partners under consideration are equally capable at their respective processing stage (possibly through a pre-processing evaluation for the new opportunity), but the partners may differ in available capacities and costs, given their current workloads. The objective is to design the supply chain by selecting one partner from each stage to meet the forecasted demand without backlog and optimize fixed alliance related and variable production and logistics costs over the given planning horizon. A solution algorithm is developed based on key properties of the problem, and is tested on empirical data sets. The overall contribution is an analytical tool that can be employed by the coordinator of the new market opportunity at the strategic level for designing supply chains based on integrated cost concerns.
A Design of the Mental Model of a Cognitive Robot (2007)

For the development of for mental model of intelligent robot, in this paper we deal with a cognitive modeling system based on the cognitive process of human being, using psychoanalysis and two kinds of emotion theories, artificial intelligence, neural network and fuzzy Petri net. Based on the psychoanalysis of Freud, we graph the psychiatric structure named 'mind sketch' by KNBN(Kohonen Network based on Belief Network). Within the mind sketch, 'emotion' is used as the base for making relative data. It is based on the emotion theory of Plutchick and the cognitive emotion theory of Ortony et al. To combine these emotional theories, a fuzzy Petri net algorithm has been proposed. And a cognitive modeling system has been developed.
Oral Lactobacillus reuteri GMN-32 treatment reduces blood glucose concentrations and promotes cardiac function in rats with streptozotocin-induced diabetes mellitus – RETRACTION (2013)

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The orientation and mechanical properties of a mesophase pitch-derived carbon film prepared by melt-blowing (2017)

A highly-oriented continuous carbon tape was prepared from a coal tar-based mesophase pitch by melt-blowing using a slit type nozzle. The molten precursor pitch was continuously extruded through the slit nozzle to produce a pitch tape along the drawing direction. The tape was oxidized, carbonized and graphitized. Examination of the crystallite orientation distribution function (CODF) for the (002) plane by X-ray diffraction revealed that the carbon layer planes were oriented parallel to the tape surface indicating a strong anisotropy. The degree of CODF largely depended on the oxidation time and carbonization temperature. The orientation was greater in the tape drawing direction than in the tape width direction. The mechanical properties largely depended on the oxidation temperature and reached maximum values at around the softening point.
Architectural optimizations for low-power, real-time speech recognition (2003)

The proliferation of computing technology to low power domains such as hand--held devices has lead to increased interest in portable interface technologies, with particular interest in speech recognition. The computational demands of robust, large vocabulary speech recognition systems, however, are currently prohibitive for such low power devices. This work begins anexploration of domain specific characteristics of speech recognition that might be exploited to achieve the requisite performance within the power constraints of such devices. We focus primarily on architectural techniques to exploit the massive amounts of potential thread level parallelism apparent in this application domain, and consider the performance / power trade-offs of such architectures. Our results show that a simple, multi-threaded, multi-pipelined processor architecture can significantly improve the performance of the time-consuming search phase of modern speech recognition algorithms, and may reduce overall energy consumption by drastically reducing dissipation of static power. We also show that the primary hurdle to achieving these performance benefits is the data request rate into the memory system, and consider some initial solutions to this problem.
Estimating Crop Yields From Multispectral Reflectance (1986)

Three reports describe research on proposed method for estimating crop yields by combining meteorological data with satellite measurements of reflected radiation to estimate crop-absorbed radiation. Concept, when tested over large areas, forms basis for evaluating crop conditions and estimating yields over regions where ground observations too costly or too difficult.