gebhart/patrepeval huggingface dataset:
The Synthesis of Acid‐ and Base‐Labile Lipopeptides on Solid Support (2003)

Lipidated peptides, including characteristic partial structures of human Ras proteins, were synthesized by means of a new solid-phase technique in 22-68 % yield. This technique gives access to farnesylated, palmitoylated, and doubly lipidated peptides as methyl esters or carboxylic acids carrying a fluorescent tag or a maleimide moiety for coupling to proteins. The peptide backbones were built up on the resin by using 9-fluorenylmethoxycarbonyl chemistry together with the oxidatively cleavable hydrazide linker. As a key step, the acid-labile farnesyl and basic-labile palmitoyl lipid groups were introduced onto the resin after the cleavage of appropriate acid- or reduction-sensitive protecting groups from the cysteine residues. Optional introduction of different fluorescent tags or a maleimide group into the peptide was followed by release of the resin-bound target peptide as the methyl ester or carboxylic acid by very mild copper(II)-mediated oxidation in slightly acidic or basic media. This new methodology should substantially facilitate the access to lipidated peptides for the study of important biological phenomena like biological signal transduction, localization, and vesicular transport.
Control of light distribution by using MEMS scanner (2020)

We controlled a light distribution of scanning light when we give the MEMS scanner drive signal by considering light distribution of the laser spot. MEMS scanner is possible to scan light by changing the angle of the mirror by giving a drive signal. There is, however, a difference between the predicted light distribution of scanning light and the actual light distribution of scanning light, and the control of light distribution was incorrect in the previous research. So we deriving the theoretical model of light distribution by MEMS scanner. And we measure the light distribution of the scanning light when we give the MEMS scanner a drive signal, then we compared measured value and the theoretical model. As the comparison result was in good agreement, it was found that the light distribution can be controlled by the theoretical model. In addition, the effect of the response time of the MEMS scanner to the drive signal on the light intensity distribution of the scanning light was investigated.
Chemical control of some broadleaved weeds which grow during winter in untilled maize lands (1986)

Several experiments have been done at Cedara in attempts to control broadleaved weeds in unfilled lands during winter. A number of herbicide treatments were tested on Conyza spp., Coronopus didymus, Gnaphalium spp., Hypochoeris radicata, Oenothera rosea and Taraxacum officinale. Where moisture conservation is an objective, these weeds, which grow during the winter, must be controlled. The most promising herbicide mixtures or combinations tested include glyphosate, paraquat and/or 2,4-D together with appropriate wetting agents. For example, consistent broad-spectrum control has been achieved with an initial application of 2,4-D + wetting agent, followed 8–10 days later by paraquat + a wetting agent. S. Afr. J. Plant Soil 1986, 3: 185–188
Causality, theories and medicine (2011)

Abstract Randomized controlled trials (RCTs) are pervasive in clinical medical research, which stands in stark contrast to other sciences such as physics, chemistry and biology. Most clinical researchers that use RCTs regard them as uncovering causal connections. R. A. Fisher best articulated the rationale for this position in 1935. According to Fisher, if randomization, blocking and replication demonstrated a connection between an intervention and an outcome, that connection is causal. This chapter argues that RCTs in clinical medicine do not reveal causal connections. Causal claims in clinical medicine, as in the rest of science, are justified by reference to a robust theory, not RCTs. Part of the argument rests on crucial differences between Fisher's use of RCTs in agriculture and the current use of RCTs in clinical medicine. Two key differences are: the different role of randomization and the legitimacy of assuming homogeneity of the intervention and control entities. A more significant part rests on the integrative power of robust theories; causal attributions are justified by demonstrating that they are, or can be, embedded in a large well-confirm framework. RCTs, by contrast, at best provide isolated input-output connections. A secondary thesis of the paper is that robust theories also allow causal claims to be well-confirmed.
Gold and Silver Staining (2002)

Silver Stains for the Identification of Neuroendocrine Cell Types, L. Grimelius Autometallographic Tracing of Gold, Silver, Bismuth, Mercury and Zinc, G. Danscher, G.W. Hacker, and M. Stoltenberg Silver- and Gold-Based Autometallography of Nanogold, J.F. Hainfeld and R.D. Powell Immunogold-Silver Staining for Light Microscopy Using Colloidal or Clustered Gold (Nanogold), G.W. Hacker, A.L.M. Cheung, R.R. Tubbs, L. Grimelius, G. Danscher, and C. Hauser-Kronberger The Protein A-Gold-Silver Staining Method, O. Fujimori Microscopic Uses of Nanogold, J.F. Hainfeld, R.D. Powell, and F.R. Furuya Combined Fluorescent and Gold Probes for Microscopic and Morphological Investigations, R.D. Powell and J.F. Hainfeld Detection of Human Papillomavirus by In Situ Hybridization Using an In Situ PCR Thermal Cycler, P. Jackson and F.A. Lewis Super Sensitive In Situ Hybridization by Tyramide Signal Amplification and Nanogold Silver Staining: The Contribution of Autometallography and Catalyzed Reporter Deposition to the Rejuvenation of In Situ Hybridization, R.R. Tubbs, J. Pettay, T. Grogan, A.L.M. Cheung, R. Powell, J. Hainfeld, C. Hauser-Kronberger, and G.W. Hacker Immunogold Labeling Techniques for Transmission Electron Microscopy: Applications in Cell and Molecular Biology, L. Lossi, P. Aimar, E. Beltramo, and A. Merighi Pre-embedding Immunoelectron Microscopy with Nanogold Immunolabeling, Silver Enhancement, and Its Stabilization by Gold, H. Sawada and M. Esaki Gold Cluster Immunoprobes: Light and Electron Microscopy, J.M. Robinson, T. Takizawa, and D.D. Vandre Highly Sensitive Ultrastructural Immunogold Detection Using Tyramide and Gold Enhancement, C. Schoefer and K. Weipoltshammer In Situ Hybridization at the Electron Microscopic Level, C. Schoefer and K. Weipoltshammer Immunogold-Silver Staining for Scanning Electron Microscopy in Cancer Research, B.-L. Wang, N. Flay, and G.W. Hacker Immunogold-Silver Scanning Electron Microscopy Using Glycerol Liquid Substitution, J. Samaj, H.-J. Ensikat, W. Barthlott, and D. Volkmann Index
Photoluminescence investigations on liquid encapsulated czochralski grown gallium arsenide (1994)

The growth aspects of 50 mm diameter gallium arsenide single crystals using LEC technique are presented. Defect investigations are made using photoluminescence studies. Photoluminescence studies on the wafers reveal the presence of the EL2 level, the presence of transition metal impurity copper which cannot be eliminated by surface treatments, and the presence of carbon. Photoluminescence scans are also obtained at room temperature to study the uniformity. The presence of carbon is also revealed by FTIR measurements.
Hybrid Communication Architectures for Distributed Smart Grid Applications (2018)

Wired and wireless communications both play an important role in the blend of communications technologies necessary to enable future smart grid communications. Hybrid networks exploit independent mediums to extend network coverage and improve performance. However, whereas individual technologies have been applied in simulation networks, as far as we know there is only limited attention that has been paid to the development of a suite of hybrid communication simulation models for the communications system design. Hybrid simulation models are needed to capture the mixed communication technologies and IP address mechanisms in one simulation. To close this gap, we have developed a suite of hybrid communication system simulation models to validate the critical system design criteria for a distributed solar Photovoltaic (PV) communications system, including a single trip latency of 300 ms, throughput of 9.6 Kbps, and packet loss rate of 1%. The results show that three low-power wireless personal area network (LoWPAN)-based hybrid architectures can satisfy three performance metrics that are critical for distributed energy resource communications.
Time-based PEB adjustment for optimizing CD distributions (2004)

In this paper we investigate the impact of bake plate temperature variability throughout the entire bake trajectory on resulting critical dimension. For a poorly-controlled bake plate, it is found that the correlation between the temperature profile and CD distribution is high throughout the entire bake cycle, including the steady state sector. However, for a well-controlled, multiple-zone bake plate, the correlation is only significant during the transient heating sector, since in those cases the steady state plate behavior has already been optimized for CDU performance. An estimate of the potential improvement yet to be gained by improvement of transient heating uniformity is calculated.
Tumour volume determination from MR images by morphological segmentation (1996)

Accurate tumour volume measurement from MR images requires some form of objective image segmentation, and therefore a certain degree of automation. Manual methods of separating data according to the various tissue types which they are thought to represent are inherently prone to operator subjectivity and can be very time consuming. A segmentation procedure based on morphological edge detection and region growing has been implemented and tested on a phantom of known adjustable volume. Comparisons have been made with a traditional data thresholding procedure for the determination of tumour volumes on a set of patients with intracerebral glioma. The two methods are shown to give similar results, with the morphological segmentation procedure having the advantages of being automated and faster.
A Novel Optical Burst Ring Network with Optical-Layer Aggregation and Flexible Bandwidth Provisioning (2011)

A novel optical burst ring network is proposed by employing fixed-tuned transmitters rather than fast tunable lasers. All-optical traffic aggregation/bypass at network nodes significantly reduces the network cost, and both wavelength and dynamically-adjusted sub-wavelength granularity can be flexibly provisioned on the optical layer.
Miniature high current metal ion source (1986)

A small, simple ion source for the production of high brightness beams of metal ions is described. A metal vapor vacuum arc discharge is used to establish the high density plasma from which the ion beam is extracted. The source is finger-sized, and can produce pulsed metal ion beams with current up to the 10 ma range. 9 refs., 6 figs.
Heme & RAGE: A new opportunistic relationship? (2021)

Heme is an iron-containing complex involved in fundamental cellular functions including oxygen transport. Free heme accumulation in blood, during intravascular hemolysis and other pathological conditions, triggers vascular dysfunction, pro-inflammatory, and prothrombotic cascade. Studies by May et al present a novel finding that heme is a ligand for RAGE and that heme binds to the V domain of RAGE and induces RAGE oligomerization. Furthermore, they show that the in vivo consequences of heme-RAGE interaction lead to a pro-inflammatory and procoagulant phenotype in the lungs. This discovery of heme as a ligand for RAGE sets the stage for probing the role of RAGE in heme homeostasis and the pathogenic role of heme-RAGE interaction in hemolytic diseases.
Periostin in fibrillogenesis for tissue regeneration: periostin actions inside and outside the cell (2011)

More than 10 years have passed since the naming of periostin derived from its expression sites in the periosteum and periodontal ligament. Following this finding, we have accumulated more data on the expression patterns of periostin, and, finally, with the generation of periostin-deficient mice, have revealed functions of periostin in the regeneration of tissues in bone, tooth, heart, and skin, and its action in cancer invasion. Since periostin is a matricellular protein, the first investigation of periostin function showed its enhancement of cell migration by acting outside the cell. On the other hand, recent observations have demonstrated that periostin functions in fibrillogenesis in association with extracellular matrix molecules inside the cell.
Enantioselective Ene Reaction of Cyclopentadiene and α,β‐Enals Catalyzed by a Diphenylprolinol Silyl Ether (2006)

Eine ganz neue Eigenschaft: Ein Diphenylprolinolsilylether erwies sich als Katalysator für die intermolekulare enantioselektive En-Reaktion zwischen α,β-Enalen und Cyclopentadien. Hier fungiert Cyclopentadien gegenüber einem α,β-Enal erstmals als En- und nicht als Dienkomponente. TBS=tert-Butyldimethylsilyl.
Dynamics of Linear Systems (Václav Doležal) (1966)

Previous article Next article Dynamics of Linear Systems (Václav Doležal)Wilfred KaplanWilfred Kaplanhttps://doi.org/10.1137/1008057PDFBibTexSections ToolsAdd to favoritesExport CitationTrack CitationsEmail SectionsAbout"Dynamics of Linear Systems (Václav Doležal)." SIAM Review, 8(2), pp. 246–247 Previous article Next article FiguresRelatedReferencesCited ByDetails Volume 8, Issue 2| 1966SIAM Review145-275 History Published online:01 August 2006 InformationCopyright © 1966 Society for Industrial and Applied MathematicsPDF Download Article & Publication DataArticle DOI:10.1137/1008057Article page range:pp. 246-247ISSN (print):0036-1445ISSN (online):1095-7200Publisher:Society for Industrial and Applied Mathematics
Pharmacogenetics of Tardive Dyskinesia: An Updated Review of the Literature (2016)

Tardive dyskinesia (TD) is a serious and potentially irreversible side effect of long-term exposure to antipsychotic medication characterized by involuntary trunk, limb and orofacial muscle movements. Various mechanisms have been proposed for the etiopathophysiology of antipsychotic-induced TD in schizophrenia patients with genetic factors playing a prominent role. Earlier association studies have focused on polymorphisms in CYP2D6, dopamine-, serotonin-, GABA- and glutamate genes. This review highlights recent advances in the genetic investigation of TD. Recent promising findings were obtained with the HSPG2, DPP6, MTNR1A, SLC18A2, PIP5K2A and CNR1 genes. More research, including collection of well-characterized samples, enhancement of genome-wide strategies, gene-gene interaction and epigenetic analyses, is needed before genetic tests with clinical utility can be made available for TD.
Characterization of the novel HLA‐DPA1*01:60 allele by sequencing‐based typing (2021)

HLA-DPA1*01:60 differs from HLA-DPA1*01:03:01:04 by one nucleotide substitution in codon 224 in exon 4.
A Physics-Based Equivalent-Circuit Model for On-Chip Symmetric Transformers With Accurate Substrate Modeling (2009)

A physics-based equivalent-circuit model for on-chip symmetric transformers is presented with all the model elements driven from fabrication specifications. Two extra coupled transformer loops are used for each coil to model the parameters of skin effect, proximity effect, and reflective effect of the substrate eddy current, respectively. Model accuracy under free space is first demonstrated using an electromagnetic field solver without considering substrate loss. Several sets of transformers were fabricated on a standard 0.18- mum 1P8M RF CMOS technology to further verify the accuracy and scalability of the proposed model. By careful comparison of <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">S</i> -parameters, coil inductance, quality factor,coupling coefficient, and maximum available gain between measured data and simulated data, model accuracy, and scalability are verified over a wide range of geometry configurations.
Quinpirole-Mediated Regulation of Dopamine D2 Receptors Inhibits Glial Cell-Induced Neuroinflammation in Cortex and Striatum after Brain Injury (2021)

Brain injury is a significant risk factor for chronic gliosis and neurodegenerative diseases. Currently, no treatment is available for neuroinflammation caused by the action of glial cells following brain injury. In this study, we investigated the quinpirole-mediated activation of dopamine D2 receptors (D2R) in a mouse model of traumatic brain injury (TBI). We also investigated the neuroprotective effects of quinpirole (a D2R agonist) against glial cell-induced neuroinflammation secondary to TBI in adult mice. After the brain injury, we injected quinpirole into the TBI mice at a dose of 1 mg/kg daily intraperitoneally for 7 days. Our results showed suppression of D2R expression and deregulation of downstream signaling molecules in ipsilateral cortex and striatum after TBI on day 7. Quinpirole administration regulated D2R expression and significantly reduced glial cell-induced neuroinflammation via the D2R/Akt/glycogen synthase kinase 3 beta (GSK3-β) signaling pathway after TBI. Quinpirole treatment concomitantly attenuated increase in glial cells, neuronal apoptosis, synaptic dysfunction, and regulated proteins associated with the blood-brain barrier, together with the recovery of lesion volume in the TBI mouse model. Additionally, our in vitro results confirmed that quinpirole reversed the microglial condition media complex-mediated deleterious effects and regulated D2R levels in HT22 cells. This study showed that quinpirole administration after TBI reduced secondary brain injury-induced glial cell activation and neuroinflammation via regulation of the D2R/Akt/GSK3-β signaling pathways. Our study suggests that quinpirole may be a safe therapeutic agent against TBI-induced neurodegeneration.
Multinuclear Olefin Polymerization Catalysts (2011)

ADVERTISEMENT RETURN TO ISSUEPREVReviewMultinuclear Olefin Polymerization CatalystsMassimiliano Delferro and Tobin J. Marks*View Author Information Department of Chemistry, Northwestern University, Evanston, Illinois 60208-3113, United States *Phone: (+1) 847 491 5658. Fax: (+1) 847 491 2990. E-mail: [email protected]Cite this: Chem. Rev. 2011, 111, 3, 2450–2485Publication Date (Web):February 17, 2011Publication History Received27 October 2010Published online17 February 2011Published inissue 9 March 2011https://pubs.acs.org/doi/10.1021/cr1003634https://doi.org/10.1021/cr1003634review-articleACS PublicationsCopyright © 2011 American Chemical SocietyRequest reuse permissionsArticle Views13218Altmetric-Citations522LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Catalysts,Copolymerization,Ethylene polymerization,Hydrocarbons,Metals Get e-Alerts
Etude de sondes d'impedance pour la caracterisation des ecoulements diphasiques liquide-liquide en conduites inclinees (1994)

Nous etudions dans cette these deux problemes: les ecoulements diphasiques liquide-liquide dans des conduites deviees, et la mesure de vitesse et de taux de presence par une sonde d'impedance. Nous commencons, dans les deux premiers chapitres, a examiner un tel capteur: ainsi au chapitre i, le comportement en presence d'une interface plane est etudie, experimentalement et numeriquement. Au chapitre ii, l'interaction bulle/sonde est etudiee experimentalement, a l'aide de cameras rapides et d'un traitement d'images. Differents phenomenes sont mis en evidence ; ils sont utilises pour interpreter la reponse du capteur. Dans le troisieme chapitre, on compare la sonde a d'autres types de capteur dans un ecoulement a bulles. On montre l'interet de la mesure simultanee du taux de presence et de la vitesse. Dans le dernier chapitre, les ecoulements diphasiques liquide-liquide en conduite inclinee sont etudies. On met clairement en evidence deux types de regimes suivant l'inclinaison. Pour les conduites faiblement deviees, on developpe un modele simple pour la concentration et la vitesse. Un bon accord est obtenu entre la theorie et l'experience (90 profils ont ete consideres). Pour les fortes inclinaisons, un modele a deux fluides conduit a un bon accord avec l'experience. Enfin, un modele de vitesse de glissement est propose
Equol, an Isoflavone Metabolite, Regulates Cancer Cell Viability and Protein Synthesis Initiation via c-Myc and eIF4G (2015)

Epidemiological studies implicate dietary soy isoflavones as breast cancer preventives, especially due to their anti-estrogenic properties. However, soy isoflavones may also have a role in promoting breast cancer, which has yet to be clarified. We previously reported that equol, a metabolite of the soy isoflavone daidzein, may advance breast cancer potential via up-regulation of the eukaryotic initiation factor 4GI (eIF4GI). In estrogen receptor negative (ER-) metastatic breast cancer cells, equol induced elevated levels of eIF4G, which were associated with increased cell viability and the selective translation of mRNAs that use non-canonical means of initiation, including internal ribosome entry site (IRES), ribosome shunting, and eIF4G enhancers. These mRNAs typically code for oncogenic, survival, and cell stress molecules. Among those mRNAs translationally increased by equol was the oncogene and eIF4G enhancer, c-Myc. Here we report that siRNA-mediated knockdown of c-Myc abrogates the increase in cancer cell viability and mammosphere formation by equol, and results in a significant down-regulation of eIF4GI (the major eIF4G isoform), as well as reduces levels of some, but not all, proteins encoded by mRNAs that are translationally stimulated by equol treatment. Knockdown of eIF4GI also markedly reduces an equol-mediated increase in IRES-dependent mRNA translation and the expression of specific oncogenic proteins. However, eIF4GI knockdown did not reciprocally affect c-Myc levels or cell viability. This study therefore implicates c-Myc as a potential regulator of the cancer-promoting effects of equol via up-regulation of eIF4GI and selective initiation of translation on mRNAs that utilize non-canonical initiation, including certain oncogenes.
DVC decompression with denoising for picture quality improvement (1997)

Digital video cassette (DVC) is a quickly proliferating new standard for real-time digital video recording. DVC is presently used both in consumer and professional applications. In this paper we describe the DVC principles, data organization and video decoding algorithm. Although typically DVC video has very good quality, at low-light levels noise becomes pronounced. We show that noise in the DVC can be reduced by digital postfiltering. For this purpose, a wavelet denoising algorithm is suggested due to its unique properties. Wavelet denoising is described in detail and results of noise reduction are illustrated on examples.