gebhart/patrepeval huggingface dataset:
Supplementary Figure 1 from Signatures of MicroRNAs and Selected MicroRNA Target Genes in Human Melanoma (2023)

Supplementary Figure 1 from Signatures of MicroRNAs and Selected MicroRNA Target Genes in Human Melanoma
Multilayered shear wave resonator consisting of c-axis tilted ZnO films (2009)

Multilayer resonator consisting of six layered ZnO films was fabricated using RF magnetron sputtering. To prevent degradation of crystalline orientation, SiO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> buffer layers were inserted between each ZnO layer. The influences of the method for SiO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> deposition on the crystalline orientation also have been investigated. Crystalline orientation of the c-axis tilted ZnO films were confirmed by XRD pole figure analysis and SEM images. In the sixth order mode shear mode resonant frequency, high efficient shear mode excitation with relatively suppressed extensional mode excitation was observed. More extensional mode suppression is expected by increasing the number of the layer.
Textbook of Pain, 2nd edition, (1990)

Pain: April 1990 - Volume 41 - Issue 1 - p 122-123 doi: 10.1016/0304-3959(90)91119-4
Data from Differential Transplantability of Tumor-Associated Stromal Cells (2023)

&lt;div&gt;Abstract&lt;p&gt;At the time of transplantation, tumor fragments contain “passenger” cells: endothelial cells and other stromal cells from the original host. Here, we investigated the fate of genetically labeled endothelial and nonendothelial stromal cells after transplantation in syngeneic mice. We report that angiogenic stroma associated with tumor or adipose tissue persists when transplanted, remains functional, and governs the initial neovascularization of grafted tissue fragments for more than 4 weeks after implantation. Surprisingly, the passenger endothelial cells survive longer than other stromal cells, which are replaced by host-activated fibroblasts after 3 weeks. The transplantability of tumor stroma suggests that the angiogenic potential of a tumor xenograft, which determines its viability, depends on the presence of passenger endothelial cells and other stromal cells within the xenograft. These studies of tumor tissue transplantation provide a platform for exploring the role of epithelial–stromal interactions in studies of tumor heterogeneity and drug resistance.&lt;/p&gt;&lt;/div&gt;
ChemInform Abstract: Effect of the pH on the Formation of NaYF4:Yb:Er Nanopowders by Co‐Crystallization in Presence of Polyethyleneimine. (2014)

Abstract Cubic single‐phase samples of the title nanopowders are obtained by addition of rare earth nitrate solutions to aqueous NaF/polyethyleneimine mixtures at pH 10, whereas single‐phase hexagonal precipitates are prepared by addition of aqueous NaF solutions to aqueous rare earth nitrate/polyethyleneimine mixtures at pH 12.
Inhibition of Transport of Indole-3-Acetic Acid in the Etiolated Hypocotyl of Phaseolus Vulgaris L. (1956)

The effect of a number of auxins and auxin analogues on the basipetal transport of illdole-3-aeotie acid (IAA) in 5-mm segments of hypocotyls of i)-day-old etiolated Phaseolus vulgari8 L. seedlings has been investigated.
Drillability of Magnesium-Based Fiber Metal Laminates Obtained via Hot Metal Pressing with Different Metal Surface Treatments (2022)

The demand for lighter and more performant aerospace and automotive components has resulted in a substantial surge in a recent interest in parts made of Fiber Metal Laminates (FMLs). For such components, drilling operations are crucial for permitting subsequent assembly. However, drillability of fiber metal laminates is critical due to the heterogeneous thermal and mechanical properties of the metal and composite that form the laminate. In this framework, the current research work aims at understanding how drilling operations can be affected by different surface treatments carried out on AZ31B magnesium alloy sheets joined with Glass Fiber Reinforced Polyamide 6 (PA6-GFRP) via hot metal pressing to form the FML. To this end, the Mg/PA6-GFRP/Mg composites were first fabricated using AZ31B surfaces that were previously treated through sandblasting, annealing, and their combination. Dry drilling was then performed using twist and spur drill bits. The feed was also varied, using two levels. The thrust force, hole quality, delamination and fiber pull-out were considered to evaluate the FMLs drillability. Results showed that the magnesium alloy sheet treatment influenced the drillability, and that the drill bit had an effect too. In particular, sheets that were both sandblasted and annealed allowed the highest drillability avoiding delamination. The use of spur drill bits improved the drillability too, reducing the FML inflection under the drill bit load.
Simultaneous Hydraulic Fracturing of Adjacent Horizontal Wells in the Woodford Shale (2009)

Abstract Hydraulic fracturing of horizontal wells in shale gas reservoirs is now an established, commercially successful technique. The evolution of the completion technique has reached the point that numerous stimulation stages through multiple perforation clusters in wellbores with some form of annular isolation is now an accepted practice. The objective is to place multiple closely spaced hydraulic fractures. This has proven to be a viable development strategy for many shale reservoirs in North America. To further enhance the recovery factor in these ultra low permeability reservoirs simultaneously hydraulically fracturing of adjacent wellbore is increasingly being tested. Most of the time this is performed in horizontal wellbores paralleling each other. The goal is to create hydraulic fractures more closely spaced than can be achieved from a single wellbore. When real time microseismic monitoring of the stimulation treatments is incorporated changes can be made "On-the-Fly" to improve the effective stimulated reservoir volume. Continental Resources has employed simultaneous hydraulic fracturing as a development strategy for their Woodford Shale acreage in the Arkoma Basin of Eastern Oklahoma. To monitor the effectiveness of the stimulations geophones have been deployed into horizontal wellbores to record microseismic events when offsetting vertical wellbores are unavailable. Cased hole sonic logs have also been run to quantify cement bond quality, estimate stress variation along the lateral, and to pick optimum perforating points. This paper reviews the methodology employed in the completion design and process. The impact of the simultaneous stimulations and geologic structure on the fracture geometry are shown as well as the impact on well productivity.
Diversity of Tn4001Transposition Products: the Flanking IS256Elements Can Form Tandem Dimers and IS Circles (2002)

We show that both flanking IS256 elements carried by transposon Tn4001 are capable of generating head-to-tail tandem copies and free circular forms, implying that both are active. Our results suggest that the tandem structures arise from dimeric copies of the donor or vector plasmid present in the population by a mechanism in which an IS256 belonging to one Tn4001 copy attacks an IS256 end carried by the second Tn4001 copy. The resulting structures carry abutted left (inverted left repeat [IRL]) and right (inverted right repeat [IRR]) IS256 ends. Examination of the junction sequence suggested that it may form a relatively good promoter capable of driving transposase synthesis in Escherichia coli. This behavior resembles that of an increasing number of bacterial insertion sequences which generate integrative junctions as part of the transposition cycle. Sequence analysis of the IRL-IRR junctions demonstrated that attack of one end by the other is largely oriented (IRL attacks IRR). Our experiments also defined the functional tips of IS256 as the tips predicted from sequence alignments, confirming that the terminal 4 bp at each end are indeed different. The appearance of these multiple plasmid and transposon forms indicates that care should be exercised when Tn4001 is used in transposition mutagenesis. This is especially true when it is used with naturally transformable hosts, such as Streptococcus pneumoniae, in which reconstitution of the donor plasmid may select for higher-order multimers.
Hyperstability of the Full Order Adaptive Observer for Vector Controlled-Induction Motor Drive without Speed-Sensor. (1992)

Vector-controlled induction motor drive without speed sensor has been widely studied. The speed estimation can be dealt with a problem of parameter estimation, based on the theory of MRAS (Model Reference Adaptive System). In such cases, the convergence and robustness of the system should be discussed. In this paper, we discuss the stability of the MRAS, which is constructed by a full-order adaptive observer of the induction motor and is used for estimating the rotor speed and identifying the stator resistance. It is verified that, under some conditions, the transfer matrix in the forward-path of MRAS is strictly positive real and the non-linear block in the feedback-path satisfies Popov's criterion. As theresult, the system is hyperstable. The influence of the set error of the rotor resistance is discussed and the design criterion for the feedback gain of the observer is given. Finally, the system is linearized for the parameter design of the speed estimator.
Performance Characteristics of an Intermeshing Disk Cutterhead for Forages (1985)

ABSTRACT DATA were obtained on the specific energy requirements of a non-conventional forage cutterhead as a function of rpm, moisture content, throughput, and cutting edge configuration. With the better edge configurations the specific energy requirement was approximately half that of published data for conventional cutterheads
Sex differences in the immune response to experimental stroke: Implications for translational research (2016)

Ischemic stroke is a leading cause of death and disability in the United States. It is known that males and females respond differently to stroke. Depending on age, the incidence, prevalence, mortality rate, and disability outcome of stroke differ between the sexes. Females generally have strokes at older ages than males and, therefore, have a worse stroke outcome. There are also major differences in how the sexes respond to stroke at the cellular level. Immune response is a critical factor in determining the progress of neurodegeneration after stroke and is fundamentally different for males and females. Additionally, females respond to stroke therapies differently from males, yet they are often left out of the basic research that is focused on developing those therapies. With a resounding failure to translate stroke therapies from the bench to the bedside, it is clearer than ever that inclusion of both sexes in stroke studies is essential for future clinical success. This Mini-Review examines sex differences in the immune response to experimental stroke and its implications for therapy development. © 2016 Wiley Periodicals, Inc.
Supplementary Table 1 from KRAB Zinc Finger Protein ZNF382 Is a Proapoptotic Tumor Suppressor That Represses Multiple Oncogenes and Is Commonly Silenced in Multiple Carcinomas (2023)

Supplementary Table 1 from KRAB Zinc Finger Protein ZNF382 Is a Proapoptotic Tumor Suppressor That Represses Multiple Oncogenes and Is Commonly Silenced in Multiple Carcinomas
Improvement of Knee Alignment and Function After Corrective Surgery for Hindfoot Deformity (2022)

Corrective surgery for hindfoot deformity can potentially change or improve ipsilateral knee alignment and function, representing an unexpected benefit of hindfoot realignment.
PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity (2017)

It is unclear whether PD-L1 on tumor cells is sufficient for tumor immune evasion or simply correlates with an inflamed tumor microenvironment. We used three mouse tumor models sensitive to PD-1 blockade to evaluate the significance of PD-L1 on tumor versus nontumor cells. PD-L1 on nontumor cells is critical for inhibiting antitumor immunity in B16 melanoma and a genetically engineered melanoma. In contrast, PD-L1 on MC38 colorectal adenocarcinoma cells is sufficient to suppress antitumor immunity, as deletion of PD-L1 on highly immunogenic MC38 tumor cells allows effective antitumor immunity. MC38-derived PD-L1 potently inhibited CD8<sup>+</sup> T cell cytotoxicity. Wild-type MC38 cells outcompeted PD-L1-deleted MC38 cells in vivo<i>,</i> demonstrating tumor PD-L1 confers a selective advantage. Thus, both tumor- and host-derived PD-L1 can play critical roles in immunosuppression. Differences in tumor immunogenicity appear to underlie their relative importance. Our findings establish reduced cytotoxicity as a key mechanism by which tumor PD-L1 suppresses antitumor immunity and demonstrate that tumor PD-L1 is not just a marker of suppressed antitumor immunity.
Diode-array UV spectrometric evidence for a concentration dependent phase transition in dilute aqueous solutions of pluronic F87 (poloxamer 237) (1995)

Incubation of dilute polymer solutions with a KI–I2 standard shows the presence of a concentration dependent phase transition for the poly(oxyethylene)+ poly(oxypropylene)+ poly(oxyethylene) block copolymer F87 (P237) using diode-array UV spectrometry; the transition is shown to be reversible and reproducible and is in agreement with previous data obtained via high-sensitivity differential scanning microcalorimetry (HSDSC).
Kinetics of Transformation of Outer Charge-Transfer Complexes to Inner Complexes1a (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetics of Transformation of Outer Charge-Transfer Complexes to Inner Complexes1aS. N. Bhat and C. N. R. RaoCite this: J. Am. Chem. Soc. 1966, 88, 14, 3216–3219Publication Date (Print):July 1, 1966Publication History Published online1 May 2002Published inissue 1 July 1966https://doi.org/10.1021/ja00966a008RIGHTS & PERMISSIONSArticle Views126Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (515 KB) Get e-Alertsclose Get e-Alerts
References (2006)

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Ferritin Nanocages To Encapsulate and Deliver Photosensitizers for Efficient Photodynamic Therapy against Cancer (2013)

Photodynamic therapy is an emerging treatment modality that is under intensive preclinical and clinical investigations for many types of disease including cancer. Despite the promise, there is a lack of a reliable drug delivery vehicle that can transport photosensitizers (PSs) to tumors in a site-specific manner. Previous efforts have been focused on polymer- or liposome-based nanocarriers, which are usually associated with a suboptimal PS loading rate and a large particle size. We report herein that a RGD4C-modified ferritin (RFRT), a protein-based nanoparticle, can serve as a safe and efficient PS vehicle. Zinc hexadecafluorophthalocyanine (ZnF16Pc), a potent PS with a high (1)O2 quantum yield but poor water solubility, can be encapsulated into RFRTs with a loading rate as high as ~60 wt % (i.e., 1.5 mg of ZnF16Pc can be loaded on 1 mg of RFRTs), which far exceeds those reported previously. Despite the high loading, the ZnF16Pc-loaded RFRTs (P-RFRTs) show an overall particle size of 18.6 ± 2.6 nm, which is significantly smaller than other PS-nanocarrier conjugates. When tested on U87MG subcutaneous tumor models, P-RFRTs showed a high tumor accumulation rate (tumor-to-normal tissue ratio of 26.82 ± 4.07 at 24 h), a good tumor inhibition rate (83.64% on day 12), as well as minimal toxicity to the skin and other major organs. This technology can be extended to deliver other metal-containing PSs and holds great clinical translation potential.
The modular architecture of Cellvibrio japonicus mannanases in glycoside hydrolase families 5 and 26 points to differences in their role in mannan degradation (2003)

beta-1,4-Mannanases (mannanases), which hydrolyse mannans and glucomannans, are located in glycoside hydrolase families (GHs) 5 and 26. To investigate whether there are fundamental differences in the molecular architecture and biochemical properties of GH5 and GH26 mannanases, four genes encoding these enzymes were isolated from Cellvibrio japonicus and the encoded glycoside hydrolases were characterized. The four genes, man5A, man5B, man5C and man26B, encode the mannanases Man5A, Man5B, Man5C and Man26B, respectively. Man26B consists of an N-terminal signal peptide linked via an extended serine-rich region to a GH26 catalytic domain. Man5A, Man5B and Man5C contain GH5 catalytic domains and non-catalytic carbohydrate-binding modules (CBMs) belonging to families 2a, 5 and 10; Man5C in addition contains a module defined as X4 of unknown function. The family 10 and 2a CBMs bound to crystalline cellulose and ivory nut crystalline mannan, displaying very similar properties to the corresponding family 10 and 2a CBMs from Cellvibrio cellulases and xylanases. CBM5 bound weakly to these crystalline polysaccharides. The catalytic domains of Man5A, Man5B and Man26B hydrolysed galactomannan and glucomannan, but displayed no activity against crystalline mannan or cellulosic substrates. Although Man5C was less active against glucomannan and galactomannan than the other mannanases, it did attack crystalline ivory nut mannan. All the enzymes exhibited classic endo-activity producing a mixture of oligosaccharides during the initial phase of the reaction, although their mode of action against manno-oligosaccharides and glucomannan indicated differences in the topology of the respective substrate-binding sites. This report points to a different role for GH5 and GH26 mannanases from C. japonicus. We propose that as the GH5 enzymes contain CBMs that bind crystalline polysaccharides, these enzymes are likely to target mannans that are integral to the plant cell wall, while GH26 mannanases, which lack CBMs and rapidly release mannose from polysaccharides and oligosaccharides, target the storage polysaccharide galactomannan and manno-oligosaccharides.
Multilayer alignment mark-induced offsets in microlithography (1988)

The scattering matrix approach to computing the image of a multilayered structure 1 is used to study alignment mark-induced offsets in microlithography. The sensitivity of the offset to different types of illumination and imaging system, to misalignments in the illumination and imaging optics, and to different alignment mark structures is presented. In particular, reverse dark-field imaging is studied in detail. The effects of nontelecentricity and coma for several alignment mark shapes are presented. The offsets are shown to be particularly sensitive to alignment mark shape and to layer thickness as well as aberrations. To obtain offsets that are less than a tenth of a micron with a given range of aberration and misalignment in the optics requires the use of particular alignment mark shapes or the use of a more sophisticated algorithm for determining the mark position from the image. The basis of the scattering matrix approach to imaging layered media is briefly discussed for the purposes of understanding the results of the model.
UTMOST: A TOOL FOR COMPREHENSIVE ASSESSMENT OF SAFETY BENEFITS (2007)

This report describes a software tool that is being developed at UMTRI to represent the effects of nonindependent safety measures (the Unified Tool for Mapping Opportunities for Safety Technology, UTMOST). The tool has as its core a model representing crashes in terms of precrash conditions, occupant characteristics, crash type, and outcome. Overlaid on this is a model of the effect of implementing each of a number of safety measures, including public policy and technological measures. This portion of the model allows for visualization of the potential benefits of various approaches and combinations of approaches to safety. UTMOST is being developed and validated using existing U.S. crash databases for the purpose of understanding future safety trends in the U.S., as well as current differences between the U.S. and selected other countries, and future trends in those countries. Our goal is to be able to use this model to: 1) predict the benefit of specific changes in policy or technology in the context of other safety measures; 2) describe the largest remaining problems after a policy or technology has been implemented; and 3) assess the overall safety performance of individual vehicles, both in general and with respect to particular demographic groups.
Miniaturization of Micro Implantable Devices With Thermosensitive Ferrite for Soft-Heating Hyperthermia (2007)

The soft heating method is one technique utilized in hyperthermia treatment. The heater that consists of thermosensitive ferrite is implanted into the body, and heated by high-frequency magnetic field. This study applies the soft heating method. A complex type of heater composed of thermosensitive ferrite wound on a metallic ring is created. This complex type of heater produces heat due to losses of hysteresis and inductive current than thermosensitive ferrite alone. Further, this heater can control the temperature of the heater by using the Curie-point. For this technique, it is necessary to miniaturize the heater and provide safety high performance. We applied the method of miniaturization to plating. The effect of plating is examined. As a result, we have approximated to the optimal thickness of the metallic ring.
Inhibition of bladder cancer invasion by Sp1‐mediated BTG2 expression via inhibition of DNA methyltransferase 1 (2014)

Significantly lower endogenous expression of B‐cell translocation gene 2 ( BTG 2) was observed in human muscle‐invasive bladder cancers ( MIBC ) than matched normal tissues and non‐muscle invasive bladder cancers ( NMIBC ). BTG 2 expression was inversely correlated with increased expression of the DNA methyltransferases DNMT 1 and DNMT 3a in MIBC , but not NMIBC , suggesting a potential role for BTG 2 expression in muscle invasion of bladder cancer. Over 90% of tumor tissues revealed strong methylation at CpG islands of the BTG 2 gene, compared with no methylation in the normal tissues, implying epigenetic regulation of BTG 2 expression in bladder carcinogenesis. By using EJ bladder cancer cells and the demethylating agent decitabine, transcription of BTG 2 was shown to be up‐regulated by inhibiting DNMT 1 expression via modification at CpG islands. DNMT 1 binding to the BTG 2 gene further regulated BTG 2 expression by chromatin remodeling, such as H3K9 dimethylation and H3K4 trimethylation, and Sp1 activation. Induced BTG 2 expression significantly reduced EJ cell tumorigenesis and invasiveness together with induction of G 2 /M arrest. These results demonstrate an important role for the BTG 2 /TIS21/PC3 gene in the progression of bladder cancers, and suggest that BTG 2 /TIS21/PC3 is a promising epigenetic target for prevention of muscle invasion in human bladder cancers.