gebhart/patrepeval huggingface dataset:
Insulysin Hydrolyzes Amyloid β Peptides to Products That Are Neither Neurotoxic Nor Deposit on Amyloid Plaques (2000)

Insulysin (EC. 3.4.22.11) has been implicated in the clearance of beta amyloid peptides through hydrolytic cleavage. To further study the action of insulysin on Abeta peptides recombinant rat insulysin was used. Cleavage of both Abeta(1-40) and Abeta(1-42) by the recombinant enzyme was shown to initially occur at the His(13)-His(14), His(14)-Gln(15), and Phe(19)-Phe(20) bonds. This was followed by a slower cleavage at the Lys(28)-Gly(29), Val(18)-Phe(19), and Phe(20)-Ala(21) positions. None of the products appeared to be further metabolized by insulysin. Using a rat cortical cell system, the action of insulysin on Abeta(1-40) and Abeta(1-42) was shown to eliminate the neurotoxic effects of these peptides. Insulysin was further shown to prevent the deposition of Abeta(1-40) onto a synthetic amyloid. Taken together these results suggest that the use of insulysin to hydrolyze Abeta peptides represents an alternative gene therapeutic approach to the treatment of Alzheimer's disease.
Phytochemical Investigation Of Some Traditional Chinese Medicines And Endophyte Cultures (2000)

For many social and environmental reasons, over the last few decades, there has been an increase in chronic and life-threatening diseases including mycoses, hyperuricemia-related disorders and some mental illnesses such as depression, anxiety and Parkinson's disease. In order to fight these diseases, compounds acting on various biological targets, including enzymes such as xanthine oxidase or monoamine oxidase, have to be screened. The enzyme xanthine oxidase catalyses the oxidation of hypoxanthine to xanthine and then to uric acid, which plays a crucial role in hyperuricemiarelated disorders such as gout and renal stones. One of the therapeutic approaches to treat these diseases is the use of xanthine oxidase inhibitors that block the production of uric acid. Monoamine oxidases (E.C.1.4.3.4) A and B catalyse the oxidative deamination of monoamines in the central nervous system and peripheral tissues. Inhibitors of MAO A are clinically useful to treat anxiety and depression since they are expected to increase both noradrenalin and serotonin levels in the brain. On the other hand, inhibition of MAO B appears to be an effective approach for the prevention and adjunct treatment of Parkinson's disease. In traditional Chinese medical practice, many medicinal herbs have been used to treat chronic diseases such as fungal infections, hyperuricemia-based disorders and mental illnesses. This usage is indicative for the presumable presence of antifungal phytochemicals and inhibitors of xanthine and monoamine oxidases. Plants do not represent the only source for interesting natural products; some endophytes ('special' microorganisms living inside the healthy host plant) are also known to produce secondary metabolites of promising pharmaceutical and/or agricultural potential. The above observations prompted us to search for natural antifungal compounds and inhibitors of xanthine and monoamine oxidases in different Chinese plants and endophyte cultures. The active constituents isolated were mainly mono-, sesqui-, di-, and triterpenes, sterols, coumarins, flavonoids, phenylethanoids, stilbenoids, alkaloids and alcohols.
Population risk factors for severe disease and mortality in COVID-19: A global systematic review and meta-analysis (2020)

Abstract Aim COVID-19 clinical presentation is heterogeneous, ranging from asymptomatic to severe cases. While there are a number of early publications relating to risk factors for COVID-19 infection, low sample size and heterogeneity in study design impacted consolidation of early findings. There is a pressing need to identify the factors which predispose patients to severe cases of COVID-19. For rapid and widespread risk stratification, these factors should be easily obtainable, inexpensive, and avoid invasive clinical procedures. The aim of our study is to fill this knowledge gap by systematically mapping all the available evidence on the association of various clinical, demographic, and lifestyle variables with the risk of specific adverse outcomes in patients with COVID-19. Methods The systematic review was conducted using standardized methodology, searching three electronic databases (PubMed, Embase, and Web of Science) for relevant literature published between 1 st January 2020 and 9 th July 2020. Included studies reported characteristics of patients with COVID-19 while reporting outcomes relating to disease severity. In the case of sufficient comparable data, meta-analyses were conducted to estimate risk of each variable. Results Seventy-six studies were identified, with a total of 17,860,001 patients across 14 countries. The studies were highly heterogeneous in terms of the sample under study, outcomes, and risk measures reported. A large number of risk factors were presented for COVID-19. Commonly reported variables for adverse outcome from COVID-19 comprised patient characteristics, including age &gt;75 (OR = 2.65 (1.81–3.90)), male sex (OR = 2.05(1.39–3.04)) and severe obesity (OR = 2.57 (1.31–5.05)). Active cancer (OR = 1.46 (1.04–2.04)) was associated with increased risk of severe outcome. A number of common symptoms and vital measures (respiratory rate and SpO2) also suggested elevated risk profiles. Conclusions Based on the findings of this study, a range of easily assessed parameters are valuable to predict elevated risk of severe illness and mortality as a result of COVID-19, including patient characteristics and detailed comorbidities, alongside the novel inclusion of real-time symptoms and vital measurements.
Long-term use of opioids in 210 officially registered patients with chronic noncancer pain in Taiwan: A cross-sectional study (2016)

This nationwide survey described the concurrent pain intensity, daily function, and various adverse effects by long-term opioids among 210 monitored outpatients with chronic noncancer pain in Taiwan. More efforts are suggested to reduce opioid prescriptions in the 30% of patients exceeding daily watchful dose.
Learning to rank for joy (2014)

User-generated content is a growing source of valuable information and its analysis can lead to a better understanding of the users needs and trends. In this paper, we leverage user feedback about YouTube videos for the task of affective video ranking. To this end, we follow a learning to rank approach, which allows us to compare the performance of different sets of features when the ranking task goes beyond mere relevance and requires an affective understanding of the videos. Our results show that, while basic video features, such as title and tags, lead to effective rankings in an affective-less setup, they do not perform as good when dealing with an affective ranking task.
Ethnothanasie et culture (2006)

que l'on soit sr qu'il l'ait dite.
Present Status in the Design of Flextensional Underwater Acoustic Transducers (1969)

The history of the flextensional transducer development is briefly outlined from the original designs developed by W. J. Toulis to its present status. Then the present designs are classified in five different categories. The state of the art with respect to the development of mathematical models for each classification is presented. Experimental data are discussed where applicable and permissible. [The development of the flextensional transducer has been partially supported by the Office of Naval Research, Acoustics Programs, and the Naval Underwater Sound Laboratory.]
Graph-based fault diagnosis method for complex electronic systems (2015)

An efficient graph-based method to analyze fault propagation characteristics in the complex electronic systems is proposed. Firstly, two test node selection methods are proposed to meet different level of diagnosis requirements, and a greedy algorithm is applied to find the best test nodes. Then, a fault propagation characteristics analysis model based on hierarchical signed directed graph is established, which combines the system's hierarchical topology structure information into model, so that it can describe the propagation characteristics more accurately and clearly. The established model can analyze fault propagation characteristics and find the fault root cause efficiently. Experimental result on an actual satellite central control system shows that, compared with traditional SDG, the fault propagation model proposed in this paper can shrink fault location searching area and shorten fault diagnosis time cost. Besides, the structure of established model is closer to the structure of real system and the reasoning process is easier to explain, which makes it more suitable to solve the fault propagation analysis and fault location tasks for complex electronic systems.
Effect of Fatigue Cyclic Loading on the Linear Viscoelastic Properties of Bituminous Mixtures (2013)

This paper focuses on the three-dimensional (3D) linear viscoelastic (LVE) behavior of bituminous mixtures and the damage occurring after a great number of cyclic loadings. Two complex modulus tests were carried out before and after a fatigue test. The complex modulus E* and complex Poisson’s ratio ν* were measured for large ranges of temperatures (from −25 to 30°C) and frequencies (from 0.03 to 10Hz). First, it is shown that the time temperature superposition principle (TTSP) is verified and applicable in the 3D case. Then, the change of the complex modulus created by fatigue test was analyzed. Lastly, a model with a continuum spectrum called two springs, two parabolic elements, one dashpot (2S2P1D), developed at the Ecole Nationale des Travaux Publics de l’Etat (ENTPE), was used to simulate the 3D linear viscoelastic behavior of the tested bituminous mixture before and after fatigue damage.
Numerics and Math (2016)

The <cmath> header Mathematical functions defines an extensive collection of common math functions in the std namespace. Unless otherwise specified, all functions are overloaded to accept all standard numerical types, with the following rules for determining the return type.
Efficient approximation of range images through data-dependent adaptive triangulations (2002)

The paper presents an efficient algorithm for generating adaptive triangular meshes from dense range images. The proposed technique consists of two stages. First, a quadrilateral mesh is generated from the given range image. The points of this mesh adapt to the surface shapes represented in the range image by grouping in areas of high curvature and dispersing in low-variation regions. The second stage splits each quadrilateral cell obtained before into two triangles. Between the two possible flips, it is chosen the one whose diagonal's direction is closest to the orientation of the discontinuities present in that cell. Both stages avoid costly iterative optimization techniques. Results with real range images are presented. They show low CPU times and accurate triangular approximations of the given images.
Hairpin and duplex formation of the DNA octamer d(m5C-G-m5C-G-T-G-m5C-G) in solution. An NMR study (1986)

The partly self-complementary DNA octamer d(m5C-G-m5C-G-T-G-m5C-G) was investigated by NMR spectroscopy in solution. It is demonstrated that this peculiar DNA fragment, under suitable conditions of concentration, salt and temperature, exclusively prefers to adopt a monomeric hairpin form with a stem of three Watson-Crick type base pairs and a loop of two residues. At high single strand concentration (8 mM DNA) and low temperature (i.e. below 295 K) the hairpin occurs in slow equilibrium with a B-dimer structure. At high ionic strength (greater than or equal to 100 mM Na+) and/or in the presence of methanol a third species appears, which is assigned to a Z-like dimer. In the B form, as well as in the Z dimer, the two central base pairs form G.T wobble pairs with the bases as major tautomers.
Metabolic shifts inZymomonas mobilisin response to growth conditions (1988)

Extensive work on ethanol production with the Gram-negative bacterium Zymomonas mobilis has revealed that this is a promising microorganism for industrial use. Concise knowledge of the physiology and metabolism of this organism provides the basis for further improvements by genetic engineering and for the optimization of Zymomonas-specific fermentation processes.
QUANTITATIVE ANALYSIS OF DIABETIC MACULAR EDEMA AFTER SCATTER LASER PHOTOCOAGULATION WITH THE SCANNING RETINAL THICKNESS ANALYZER (1999)

Our results suggest that subclinical macular edema occurs after scatter laser photocoagulation. The retinal thickness analyzer is a sensitive tool for early detection of macular edema after laser treatment, because increases in retinal thickness as small as 34 microm cannot be assessed by slit-lamp biomicroscopy.
Data from PACE4 Undergoes an Oncogenic Alternative Splicing Switch in Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;Inhibition of PACE4, a proprotein convertase that is overexpressed in prostate cancer, has been shown to block cancer progression in an androgen-independent manner. However, the basis for its overexpression and its growth-inhibitory effects are mitigated and uncertain. Here, we report that PACE4 pre-mRNA undergoes DNA methylation–sensitive alternative splicing of its terminal exon 3′ untranslated region, generating an oncogenic, C-terminally modified isoform (PACE4-altCT). We found this isoform to be strongly expressed in prostate cancer cells, where it displayed an enhanced autoactivating process and a distinct intracellular routing that prevented its extracellular secretion. Together, these events led to a dramatic increase in processing of the progrowth differentiation factor pro-GDF15 as the first PACE4 substrate to be identified in prostate cancer. We detected robust expression of PACE4-altCT in other cancer types, suggesting that an oncogenic switch for this proenzyme may offer a therapeutic target not only in advanced prostate cancer but perhaps also more broadly in human cancer. &lt;i&gt;Cancer Res; 77(24); 6863–79. ©2017 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Diagnosis of Polysplenia Syndrome (1971)

Three cases of polysplenia were diagnosed by visceral arteriography. Each patient had a common celiacomesenteric artery. The origin of supply to the dislocated splenic lobules was variable. Such lobules were readily demonstrated at various sites along the greater curvature of the stomach. Plain chest film findings which suggest polysplenia include (a) a stomach position opposite the cardiac apex-aortic arch, (b) malrotation of the gut on barium studies, (c) an enlarged azygos or hemiazygos vein, especially with malposition of the stomach and/or (d) dextrocardia, and (e) absence of the eparterial bronchus. The authors suggest that visceral arteriography is the only definite means of achieving a precise diagnosis.
Supplementary Table S3 from Intratumoral CD16<sup>+</sup> Macrophages Are Associated with Clinical Outcomes of Patients with Metastatic Melanoma Treated with Combination Anti-PD-1 and Anti-CTLA-4 Therapy (2023)

&lt;p&gt;Differential expression analysis gene list of FACS sorted CD16+ compared to CD16- macrophages from human melanoma dissociates.&lt;/p&gt;
Opioid Peptides from Milk Proteins (1986)

Journal Article Opioid Peptides from Milk Proteins Get access Masaaki Yoshikawa, Masaaki Yoshikawa Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Kyoto 606, Japan Search for other works by this author on: Oxford Academic Google Scholar Fumito Tani, Fumito Tani Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Kyoto 606, Japan Search for other works by this author on: Oxford Academic Google Scholar Takashi Yoshimura, Takashi Yoshimura Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Kyoto 606, Japan Search for other works by this author on: Oxford Academic Google Scholar Hideo Chiba Hideo Chiba Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Kyoto 606, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 50, Issue 9, 1 September 1986, Pages 2419–2421, https://doi.org/10.1080/00021369.1986.10867763 Published: 01 September 1986 Article history Received: 05 June 1986 Published: 01 September 1986
In Vivo Comparison of Replamineform, Silastic, and Bioelectric Polyurethane Arterial Grafts (1979)

The replamineform process allows fabrication of microporous prostheses with control of both pore diameter and structural geometry by means of a variety for biomaterials. Tubular prostheses 3 cm long, 6 mm inside diameter, and 1 mm wall thickness were made of Silastic or Bioelectric Polyurethane (BEP) with use of a template of the echinoderm Heterocentrotus mammillatus. Pore diameter of the prosthesis wall was 18 to 25 mu. Light and scanning-electron microscopy of grafts removed between 1 and 32 weeks demonstrated that organization and endothelialization of neointima were similar for both polymers, being complete by 4 to 8 weeks. However, the character of prosthesis wall ingrowth was strikingly different: the microporous lattice of BEP was completely ingrown early, but was apparently fragmented by continued granulomatous inflammation by 32 weeks, while Silastic generated minimal inflammatory response and slower fibrous tissue and capillary ingrowth. Thus, with Silastic and BEP, similarities in neointima organization appeared independent of distinct differences in wall ingrowth. The replamineform process is a unique means of studying surface healing and wall ingrowth of different biomaterials as microporous vascular prostheses in a controlled fashion.
Reliability of Wafer-Level Ultra-Thinning down to 3 µm using 20 nm-Node DRAMs (2021)

3D integration (3DI) with bumpless Wafer-on-Wafer (WOW) technology is expected to be one of the most promising methods for improving device performance. One of the key points of this technology is how to reduce the Si as thin as possible without degrading the device characteristics. In this work, ultra-thin DRAMs with 5 μm- and 3 μm-thick Si wafers have been developed for WOW applications. The influences of Cu contamination and backside defects on device reliability were evaluated using 3 μm-thick Si wafer for the first time. The backside defects were compared with thinning methods using grinding and chemical mechanical polishing (CMP), respectively. It was found that the refresh time according to the normalized failure rate below 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-6</sup> was shortened due to Cu contamination after CMP process. The refresh time was improved by increasing the thickness of the backside defects layer using grinding. However, these defects may cause degradation of the standby currents when the Si thickness closes to depletion region at 3 μm in thickness. Thus, it is important how to design the diffusion length of defects carefully to prevent incoming defects to depletion layer, taking the standby currents and the retention characteristics into account.
A New Systematic Small for Size Resection for Liver Tumors Invading the Middle Hepatic Vein at its Caval Confluence (2009)

IOUS assistance systematically allows conservative resection of liver tumor invading the MHV at caval confluence. This drastically limits the need for larger resections, and further broadens the role of IOUS in optimizing the surgical strategy.
Whole-cell cancer vaccination: from autologous to allogeneic tumor- and dendritic cell-based vaccines (2008)

The field of tumor vaccination is currently undergoing a shift in focus, from individualized tailor-made vaccines to more generally applicable vaccine formulations. Although primarily predicated by financial and logistic considerations, stemming from a growing awareness that clinical development for wide-scale application can only be achieved through backing from major pharmaceutical companies, these new approaches are also supported by a growing knowledge of the intricacies and minutiae of antigen presentation and effector T-cell activation. Here, the development of whole-cell tumor and dendritic cell (DC)-based vaccines from an individualized autologous set-up to a more widely applicable allogeneic approach will be discussed as reflected by translational studies carried out over the past two decades at our laboratories and clinics in the vrije universiteit medical center (VUmc) in Amsterdam, The Netherlands.
“Wow! You Are So Beautiful Today!” (2014)

Beauty e-Experts, a fully automatic system for makeover recommendation and synthesis, is developed in this work. The makeover recommendation and synthesis system simultaneously considers many kinds of makeover items on hairstyle and makeup. Given a user-provided frontal face image with short/bound hair and no/light makeup, the Beauty e-Experts system not only recommends the most suitable hairdo and makeup, but also synthesizes the virtual hairdo and makeup effects. To acquire enough knowledge for beauty modeling, we built the Beauty e-Experts Database, which contains 1,505 female photos with a variety of attributes annotated with different discrete values. We organize these attributes into two different categories, beauty attributes and beauty-related attributes. Beauty attributes refer to those values that are changeable during the makeover process and thus need to be recommended by the system. Beauty-related attributes are those values that cannot be changed during the makeup process but can help the system to perform recommendation. Based on this Beauty e-Experts Dataset, two problems are addressed for the Beauty e-Experts system: what to recommend and how to wear it, which describes a similar process of selecting hairstyle and cosmetics in daily life. For the what-to-recommend problem, we propose a multiple tree-structured supergraph model to explore the complex relationships among high-level beauty attributes, mid-level beauty-related attributes, and low-level image features. Based on this model, the most compatible beauty attributes for a given facial image can be efficiently inferred. For the how-to-wear-it problem, an effective and efficient facial image synthesis module is designed to seamlessly synthesize the recommended makeovers into the user facial image. We have conducted extensive experiments on testing images of various conditions to evaluate and analyze the proposed system. The experimental results well demonstrate the effectiveness and efficiency of the proposed system.
Photochemical Charge Separation within Aromatic Hydrazines and the Effect of Excited-State Intervalence in Dihydrazines (2005)

Photolysis into the longest wavelength absorption band of 2-tert-butyl-2,3-diazabicyclo[2.2.2]oct-3-yl hydrazine (Hy) substituted naphthalenes causes aryl group reduction electron transfer to give (+)Hy-Ar(-). Electrooptical absorption measurements characterize the charge separation properties from these bands. Emission studies demonstrate that the separation between absorption and emission maxima for symmetrically disubstituted compounds is smaller than that for monosubstituted compounds, which is attributed to excited-state intervalence. The excited-state diabatic surfaces may be described as a Hy(+)-NA(- )-Hy(0), Hy(0)-NA(-)-Hy(+) pair, for which electronic interaction produces a double minimum that qualitatively resembles that in the ground state of the disubstituted intervalence radical cations.