gebhart/patrepeval huggingface dataset:
Heart Rate Regulation as Skill Learning: Strength‐Endurance versus Cardiac Reaction Time (1976)

ABSTRACT Fleishman's (1966) model of complex motor skill learning is applied to viscera) self‐regulation. Five different underlying abilities are illustrated: strength, endurance, steadiness, control precision, and reaction time. In the experiment, 16 subjects were pre and post tested with instructions alone for degree of cardiac Strength and Endurance control (SE) (maximally increase or decrease heart rate and sustain it for a minute) and degree of cardiac Reaction Time control (RT) (produce a small, 3 sec burst of increased or decreased heart rate as quickly as possible to the onset of a trial). All subjects received heart rate biofeedback during training, but half practiced SE while the other practiced RT. It was predicted that cardiac learning would be specific to the skill practiced during biofeedback, with little transfer to the other task. The data indicated that SE training led to improved SE control (30%) accompanied by a slight decrement in RT control (‐5%). Conversely, RT training led to markedly improved RT control (120%)H accompanied by a small decrement in SE control(18%). The value of conceptualizing complex visceral skills as reflecting learned patterns of underlying neurophysiological abilities is illustrated.
Some necessary and some sufficient trace inequalities for Euclidean distance matrices (2007)

Abstract In this article, we use known bounds on the smallest eigenvalue of a symmetric matrix and Schoenberg's theorem to provide both necessary as well as sufficient trace inequalities that guarantee a matrix D is a Euclidean distance matrix, EDM . We also provide necessary and sufficient trace inequalities that guarantee a matrix D is an EDM generated by a regular figure. Keywords: Euclidean distance matricesSmallest eigenvalueAMS Subject Classifications15A4515A57 Acknowledgements Research supported by the Natural Sciences and Engineering Research Council of Canada and MITACS. Notes 1 Some authors refer to these as EDMs of strength one Citation6.
NEUROPHYSIOLOGY AND HUMAN TASTE SENSATIONS (1986)

ABSTRACT Taste sensations are of primary importance in food flavor. Any attempt to synthesize chemically the flavor of a natural food involves mainly taste active compounds. Many distinct taste sensations can be identified as associated with food compounds. Thirteen different taste sensations are discussed herein. These different taste sensations are differentiated on the basis of stimulus chemistry and peripheral nerve conveying the taste information. Neurophysiological examination of the peripheral nerves involved in taste reveals that the sensory neurons can, in any species, be subdivided into distinct neural groups. These different neural groups respond to distinct classes of chemicals and often display different neurophysiological characteristics. Altogether in four different species, nine functional neural taste groups can be distinguished. In many cases, these neural groups can be taken as analogs for the neural groups assumed to underly human taste sensations. Distinct human taste sensations can be considered to arise from the excitation or inhibition of different neural groups. For certain human taste sensations there are no animal neural analog groups; and for certain neural groups there are no analog human sensations.
Deciphering protein evolution and fitness landscapes with latent space models (2019)

Protein sequences contain rich information about protein evolution, fitness landscapes, and stability. Here we investigate how latent space models trained using variational auto-encoders can infer these properties from sequences. Using both simulated and real sequences, we show that the low dimensional latent space representation of sequences, calculated using the encoder model, captures both evolutionary and ancestral relationships between sequences. Together with experimental fitness data and Gaussian process regression, the latent space representation also enables learning the protein fitness landscape in a continuous low dimensional space. Moreover, the model is also useful in predicting protein mutational stability landscapes and quantifying the importance of stability in shaping protein evolution. Overall, we illustrate that the latent space models learned using variational auto-encoders provide a mechanism for exploration of the rich data contained in protein sequences regarding evolution, fitness and stability and hence are well-suited to help guide protein engineering efforts.
Tobacco Smoking and Its Impact on Corneal Biomechanics (2010)

investigated the effect ofdiabetes mellitus on various corneal biomechanical parame-ters, as measured by the Ocular Response Analyzer (ORA;Reichert, Inc., Depew, NY). The rationale of their study is veryinteresting. To my surprise, the authors showed a decrease incorneal hysteresis (CH) rather than the expected increase.Several factors suggest that diabetes mellitus would actuallyenhance corneal biomechanics by an increase in the cross-linking rate: First, an earlier retrospective study showed alower incidence of keratoconus in diabetic patients, suggestingthat corneal biomechanics are enhanced in diabetic corneas.
Nanoscale Multi-Line Patterning Using Sidewall Structure (2002)

A patterning technique to define nanoscale multiple lines is developed and optimized using sidewall structure. About 50 nm poly-Si multiple lines, which have 70 nm as one of the narrowest space, are defined by sidewall multi-line patterning technique. These patterns have a good uniformity (deviation 1.5–4.7 nm). In addition, we can control line/space of patterns very easily by sidewall width control in this technique. And this is free from the proximity effect because of the process using sidewall hard mask. So, it is expected that the sidewall multi-line patterning technique can be applied to fabricate single electron devices, quantum devices, and other nanoscale devices.
BC Hydro's on-line transient stability assessment (TSA) model development, analysis and post-processing (1995)

This paper presents the theoretical background and analytical methods developed for BC Hydro's on-line transient stability assessment (TSA) module. It concentrates on the preprocessing modeling, stability analysis/margin calculation and post processing techniques, the architecture, hardware and implementation are presented in a companion paper. BC Hydro's TSA has been tested with thousands of cases using a large scale detailed basecase derived for on-line analysis, sample tests are presented in this paper.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A H-titanate nanotube with superior oxidative desulfurization selectivity (2017)

H-TiNTs were used as catalysts for the oxidation of dibenzothiophene. Compounds existing in fuels do not show any influence on DBT removal. Ti-hydroperoxide is responsible for the superior selectivity of H-TiNTs. The selective oxidation mechanism of H-TiNTs was proposed.
Safety, efficacy, and biomarker analysis of response to engineered tumor-infiltrating lymphocytes secreting anti-PD-1 antibody in recurrent glioblastoma: An open-label, two-arms, phase 1 study. (2023)

2042 Background: Adoptive cell therapy using tumor-infiltrating lymphocytes (TILs) is effective against solid tumors with convincing evidence. But T-cells infused were exhausted when they encountered PD-1-mediated immunosuppression in the microenvironment. Here, we generated a modified autologous TILs secreting antibody targeting PD-1 (PD1-TIL), and conducted a first-in-human, two arms, phase 1 study (NCT03347097) in recurrent glioblastoma who had a poor prognosis with estimated 6-9 months of median overall survival (OS). Methods: Patients were included to be treated with PD1-TIL or TIL cell products intravenously every one month following surgery. The primary endpoint was safety and feasibility. The secondary endpoints were disease control rate (DCR), OS, immunologic responses and biomarker analysis. The clinical response to cell therapy was assessed by MRI according to iRANO criteria. Here, patients with clinical benefit (CR, PR, and SD) were defined as responder. Results: A total of 21 consecutive patients (median age 45 years, range 20–64) received infusions of cell products (7 patients for PD1-TIL with 1 excluded, 14 patients for TIL with 2 excluded). 52% (11/21) and 29% (6/21) of 21 patients had methylated MGMT promoter and IDH1/2 mutant respectively. No significant differences in baseline characteristics between groups were found. Both of PD1-TIL and TIL infusions were well tolerated with no unexpected high-grade adverse events. Of 7 evaluable patients in PD1-TIL group, 1 had PR for more than 26 months, 2 had SD lasting for 7.7 months and 24 months, and 4 had PD after infusion. The DCR, 1-year and 2-years survival rates in PD1-TIL group were 43% (3/7), 86% (6/7) and 29% (2/7) respectively. In TIL group, 3 patients had SD and the others had PD. The DCR, 1-year and 2-years survival rates in TIL group were half of that in PD1-TIL group. Survival analysis showed that patients treated by PD1-TIL had extended OS than those received TIL (16.1 vs. 11.2 months, P = 0.047). Among 21 patients, clinical responders had significantly improved OS (30.9 vs. 10.7 months, P = 0.001) than non-responders. We also found a high capacity for engraftment and persistence of infused TILs in peripheral blood which could be detectable at 6 months after treatment. Existence of neoantigen-reactive T cell clonotypes in cell products may be important for responding because missing of missense mutations predicted to generate a neoantigen after cell therapy was a remarkable signature in responders. Responsive tumors were also associated with tumor microenvironment profiles. Conclusions: This first-in-human study establish the preliminary feasibility, safety and encouraging efficacy of PD1-antibody-secreting TILs, and may constitute a new treatment strategy by T-cell genetic engineering in glioblastoma. Clinical trial information: NCT03347097 .
Degradation of Alkyl Methyl Ketones by Pseudomonas veronii MEK700 (2007)

Pseudomonas veronii MEK700 was isolated from a biotrickling filter cleaning 2-butanone-loaded waste air. The strain is able to grow on 2-butanone and 2-hexanol. The genes for degradation of short chain alkyl methyl ketones were identified by transposon mutagenesis using a newly designed transposon, mini-Tn5495, and cloned in Escherichia coli. DNA sequence analysis of a 15-kb fragment revealed three genes involved in methyl ketone degradation. The deduced amino acid sequence of the first gene, mekA, had high similarity to Baeyer-Villiger monooxygenases; the protein of the second gene, mekB, had similarity to homoserine acetyltransferases; the third gene, mekR, encoded a putative transcriptional activator of the AraC/XylS family. The three genes were located between two gene groups: one comprising a putative phosphoenolpyruvate synthase and glycogen synthase, and the other eight genes for the subunits of an ATPase. Inactivation of mekA and mekB by insertion of the mini-transposon abolished growth of P. veronii MEK700 on 2-butanone and 2-hexanol. The involvement of mekR in methyl ketone degradation was observed by heterologous expression of mekA and mekB in Pseudomonas putida. A fragment containing mekA and mekB on a plasmid was not sufficient to allow P. putida KT2440 to grow on 2-butanone. Not until all three genes were assembled in the recombinant P. putida was it able to use 2-butanone as carbon source. The Baeyer-Villiger monooxygenase activity of MekA was clearly demonstrated by incubating a mekB transposon insertion mutant of P. veronii with 2-butanone. Hereby, ethyl acetate was accumulated. To our knowledge, this is the first time that ethyl acetate by gas chromatographic analysis has been definitely demonstrated to be an intermediate of MEK degradation. The mekB-encoded protein was heterologously expressed in E. coli and purified by immobilized metal affinity chromatography. The protein exhibited high esterase activity towards short chain esters like ethyl acetate and 4-nitrophenyl acetate.
ChemInform Abstract: Synthesis and Biological Evaluation of 2,3‐Diarylthiophenes as Selective Cox‐2 and Cox‐1 Inhibitors. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
On the average near-far resistance for MMSE detection of direct sequence CDMA signals with random spreading (1999)

The performance of a near-far-resistant, finite-complexity, minimum mean squared error (MMSE) linear detector for demodulating direct sequence (DS) code-division multiple access (CDMA) signals is studied, assuming that the users are assigned random signature sequences. We obtain tight upper and lower bounds on the expected near-far resistance of the MMSE detector, averaged over signature sequences and delays, as a function of the processing gain and the number of users. Since the MMSE detector is optimally near-far-resistant, these bounds apply to any multiuser detector that uses the same observation interval and sampling rate. The lower bound on near-far resistance implies that, even without power control, linear multiuser detection provides near-far-resistant performance for a number of users that grows linearly with the processing gain.
Data warehouse design to support customer relationship management analyses (2004)

CRM is a strategy that integrates the concepts of Knowledge Management, Data Mining, and Data Warehousing in order to support the organization's decision-making process to retain long-term and profitable relationships with its customers. In this paper, we first present the design implications that CRM poses to data warehousing, and then propose a robust multidimensional starter model that supports CRM analyses. We then present sample CRM queries, test our starter model using those queries and define two measures (% success ratio and CRM suitability ratio) by which CRM models can be evaluated. We finally introduce a preliminary heuristic for designing data warehouses to support CRM analyses. Our study shows that our starter model can be used to analyze various profitability analyses such as customer profitability analysis, market profitability analysis, product profitability analysis, and channel profitability analysis.
A method for the construction of acoustic Markov models for words (1993)

A technique for constructing Markov models for the acoustic representation of words is described. Word models are constructed from models of subword units called fenones. Fenones represent very short speech events and are obtained automatically through the use of a vector quantizer. The fenonic baseform for a word-i.e., the sequence of fenones used to represent the word-is derived automatically from one or more utterances of that word. Since the word models are all composed from a small inventory of subword models, training for large-vocabulary speech recognition systems can be accomplished with a small training script. A method for combining phonetic and fenonic models is presented. Results of experiments with speaker-dependent and speaker-independent models on several isolated-word recognition tasks are reported. The results are compared with those for phonetics-based Markov models and template-based dynamic programming (DP) matching.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Carnosine Levels in the Muscle Tissues of Sturgeons and Their Hybrids (2020)

The determination of the carnosine level in fish muscle tissues is helpful for the purposes of general biology and comparative muscle physiology of various fish species; it may be also useful for estimation of the nutritional value of fish products. The mass-spectrometric method of the determination of carnosine in muscle tissues has been improved and tested in this work. The carnosine levels in the muscles of the Russian sturgeon, Siberian sturgeon, sterlet, hybrid of sterlet and kaluga, hybrid of Siberian sturgeon and kaluga have been determined for the first time with this method. The starlet-and-kaluga hybrid, regardless of sex, contains 3.33 times more carnosine than the sterlet (p < 0.01). The female hybrid of Siberian sturgeon and kaluga contains 1.50 times less carnosine than the female Siberian sturgeon (p < 0.1). Since carnosine consumption is important for carnosine biosynthesis in human muscles, the hybridization of sterlet with kaluga is more efficient in terms of nutrition value than pure sterlet breeding, and the hybridization of Siberian sturgeon with kaluga is less effective than sturgeon breeding.
Effects of climate change on methane emissions from seafloor sediments in the Arctic Ocean: A review (2016)

Abstract Large quantities of methane are stored in hydrates and permafrost within shallow marine sediments in the Arctic Ocean. These reservoirs are highly sensitive to climate warming, but the fate of methane released from sediments is uncertain. Here, we review the principal physical and biogeochemical processes that regulate methane fluxes across the seabed, the fate of this methane in the water column, and potential for its release to the atmosphere. We find that, at present, fluxes of dissolved methane are significantly moderated by anaerobic and aerobic oxidation of methane. If methane fluxes increase then a greater proportion of methane will be transported by advection or in the gas phase, which reduces the efficiency of the methanotrophic sink. Higher freshwater discharge to Arctic shelf seas may increase stratification and inhibit transfer of methane gas to surface waters, although there is some evidence that increased stratification may lead to warming of sub‐pycnocline waters, increasing the potential for hydrate dissociation. Loss of sea‐ice is likely to increase wind speeds and sea‐air exchange of methane will consequently increase. Studies of the distribution and cycling of methane beneath and within sea ice are limited, but it seems likely that the sea‐air methane flux is higher during melting in seasonally ice‐covered regions. Our review reveals that increased observations around especially the anaerobic and aerobic oxidation of methane, bubble transport, and the effects of ice cover, are required to fully understand the linkages and feedback pathways between climate warming and release of methane from marine sediments.
A QRS Scoring System for Assessing Left Ventricular Function after Myocardial Infarction (1982)

A QRS scoring system for estimating the size of a myocardial infarct was evaluated in 55 patients who did not have left ventricular hypertrophy or conduction abnormalities. Serial 12-lead surface electrocardiograms were scored according to a 29-point system based on the duration of Q and R waves and on the ratios of R-to-Q amplitude and R-to-S amplitude. The scores were proportional to the severity of wall-motion abnormalities, which was determined by radionuclide blood-pool scanning and which correlated inversely with the radionuclide-determined left ventricular ejection fraction (LVEF). A score less than 3 was 93 per cent sensitive and 88 per cent specific for both severe regional dyssynergy and major depression of the global LVEF. The following equation was used to estimate the LVEF from the QRS score: LVEF (%) = 60 - (3 x QRS score). After acute myocardial infarction, an electrocardiogram can provide important indirect quantitative information about left ventricular function.
Action of Pirenzepine on the Human Urinary Bladder in Vitro (1986)

The novel compound pirenzepine was tested for its antimuscarinic effect on the human urinary bladder "in vitro." Its behavior towards the contractions induced by acetylcholine or bethanechol and towards electrically induced contractions was identical to that of atropine. However, its potency was 100 to 300 times lower than that of atropine. Results obtained with ganglion blocking agents, tetrodotoxin and cooled preparations of urinary bladder seem to indicate the virtually total absence of ganglionic cells. On the other hand they point out the fundamental role of post-synaptic muscarinic M2 receptors as the most important component of the cholinergic system in the bladder. Of course the existence of other transmitters released at the cholinergic nerve endings after electrical field stimulation cannot be excluded on the basis of our experiments.
Robust System and Cross-Layer Design for H.264/AVC-Based Wireless Video Applications (2006)

H.264/AVC is an essential component in emerging wireless video applications, thanks to its excellent compression efficiency and network-friendly design. However, a video coding standard itself is only a single component within a complex system. Its effectiveness strongly depends on the appropriate configuration of encoders, decoders, as well as transport and network features. The applicability of different features depends on application constraints, the availability and quality of feedback and cross-layer information, and the accessible quality-of-service (QoS) tools in modern wireless networks. We discuss robust integration of H.264/AVC in wireless real-time video applications. Specifically, the use of different coding and transport-related features for different application types is elaborated. Guidelines for the selection of appropriate coding tools, encoder and decoder settings, as well as transport and network parameters are provided and justified. Selected simulation results show the superiority of lower layer error control over application layer error control and video error resilience features.
A Star's Journey Through a Spiral Galaxy (2020)

Previous studies have shown that the time dilation of a process (e.g., a ticking clock) is caused by the velocity of the process relative to a medium that supports the propagation of nature’s force particles. Proper operation of the Global Positioning System requires that the Earth and this medium move in concert about the Sun and about the galactic center. Absent this concerted motion there would be a cyclic variation in the time dilation of the GPS satellite clocks, a variation that is not observed. We examine two models of gravity to determine which supports the concerted motion of the medium, the Sun and the Earth. We ﬁnd that only one of the two models supports this concerted motion.