gebhart/patrepeval huggingface dataset:
THE TROMSØ STUDY (1990)

Gamma-glutamyltransferase was measured in 10,942 males aged 12-62 years and 10,840 females aged 12-59 years screened in a health survey program. The distribution was right-skewed, with medians of 17 and 12 units/liter for males and females, respectively. Fewer than 5.5% of the males and 1.5% of the females had values exceeding 50 units/liter, reflecting the modest use of alcohol in Norway. In sex-specific multiple regression analyses, gamma-glutamyl-transferase showed a strong positive association with body mass index, alcohol use, and total serum cholesterol and a somewhat weaker positive association with serum triglycerides, high density lipoprotein cholesterol, heart rate, blood pressure, use of analgesics, and time since last meal. Strong negative associations were found for coffee consumption, hour of the day at which the examination was performed and, in males, physical activity. In females, use of oral contraceptives and menopause were positively associated with gamma-glutamyltransferase, whereas pregnant females had lower values. In conclusion, the gamma-glutamyltransferase level in the Tromsø population was low, with marked and consistent sex differences which probably are physiologic. Within its normal range, gamma-glutamyltransferase has many other, even stronger determinants than alcohol consumption.
Force-Feedback Cursor Control (1989)

Robot controller moves cursor and manipulates images. Use of force-feedback hand-held controller proposed to help computer operators position cursors on computer video displays. To control cursor, hand controller replaces joystick or electronic mouse. Operator presses button on handle to obtain action when cursor reaches desired position indicated by icon or image. Controller has additional degrees of freedom.
Supplementary Figure 1 from Alternatively Spliced RAGEv1 Inhibits Tumorigenesis through Suppression of JNK Signaling (2023)

Supplementary Figure 1 from Alternatively Spliced RAGEv1 Inhibits Tumorigenesis through Suppression of JNK Signaling
Liquid Crystalline Ionic Liquids (2011)

This chapter contains sections titled: Liquid Crystalline Ionic Liquids by the Chemical Modification of Ionic Liquids Self-Assembly of Ionic Liquids with Liquid Crystal Molecules Anisotropic Ionic Conductivities of Ionic Liquid Crystals Related Materials Summary References
Enzymes: principles and biotechnological applications (2015)

Enzymes are biological catalysts (also known as biocatalysts) that speed up biochemical reactions in living organisms, and which can be extracted from cells and then used to catalyse a wide range of commercially important processes. This chapter covers the basic principles of enzymology, such as classification, structure, kinetics and inhibition, and also provides an overview of industrial applications. In addition, techniques for the purification of enzymes are discussed.
Linking the fractional derivative and the Lomnitz creep law to non-Newtonian time-varying viscosity (2016)

Many of the most interesting complex media are non-Newtonian and exhibit time-dependent behavior of thixotropy and rheopecty. They may also have temporal responses described by power laws. The material behavior is represented by the relaxation modulus and the creep compliance. On the one hand, it is shown that in the special case of a Maxwell model characterized by a linearly time-varying viscosity, the medium's relaxation modulus is a power law which is similar to that of a fractional derivative element often called a springpot. On the other hand, the creep compliance of the time-varying Maxwell model is identified as Lomnitz's logarithmic creep law, making this possibly its first direct derivation. In this way both fractional derivatives and Lomnitz's creep law are linked to time-varying viscosity. A mechanism which yields fractional viscoelasticity and logarithmic creep behavior has therefore been found. Further, as a result of this linking, the curve-fitting parameters involved in the fractional viscoelastic modeling, and the Lomnitz law gain physical interpretation.
High gain driven right leg circuit for dry electrode systems (2016)

This paper presents an improved driven right leg (DRL) circuit compensation together with a practical implementation. The proposed design allows to increase common mode voltage attenuation compared with the widely used dominant pole compensation while maintaining the same proven stability margin and design criteria, and requiring only a modification of its passive feedback network. A sample implementation of the proposed DRL was obtained estimating the values of interference model parameters for a dry electrode measurement system. A dominant pole compensated DRL with the same stability margin was also implemented in order to experimentally validate the proposed design against this established alternative. Measurements were conducted under both controlled and uncontrolled interference conditions. The proposed compensation experimentally demonstrated achieving a better reduction of power line harmonics, with a peak comparative improvement of around 18 dB at 50 Hz.
First report of screening an asymptomatic population for cancer: the yield of an integrated cancer prevention center. (2010)

Screening asymptomatic subjects identifies a significant number of neoplastic lesions at an early stage. Incorporating data on genetic polymorphisms in the APC and CD24 genes can further identify individuals who are at increased risk for cancer. Cancer can be prevented and/or diagnosed at an early stage using the screening facilities of a multidisciplinary outpatient clinic.
Influence of FISDW depinning on the quantized hall effect in (TMTSF)/Sub 2/pf/Sub 6/ (1994)

Summary form only given. The Hall resistance as a function of the current along the conducting chains is investigated in the magnetic-field-induced spin-density wave (FISDW) phases of (TMTSF)/sub 2/PF/sub 6/, (TMTSF stands for tetramethyltetraselenafulvalene). Recently, we have reported/sub 1/ a nonlinear Hall resistance decreasing strongly with increasing current above a well-defined threshold current. Now we present strong evidence that the nonlinearity arises from the depinning of the FISDW. We show that by applying a radio-frequency excitation superimposed on a dc bias, interference features appear in the differential Hall resistance whwnever the phase change rate of the sliding FISDW is equal to the frequency of the rf excitation (Shapiro interference).
Retinoblastoma Loss in Cancer: Casting a Wider Net (2019)

Capturing both genomic and nongenomic mechanisms of retinoblastoma gene dysfunction has potential to improve risk stratification and patient selection for biomarker-driven therapy. A 186-gene expression signature is capable of identifying Rb loss across cancer types, providing a new framework for assessing Rb dysfunction based on transcriptome data.<i>See related article by Chen et al., p. 4290</i>.
C(sp2)–H Functionalization of Imidazole at the C2- and C4-Position via Palladium-Catalyzed Isocyanide Insertion Leading to Indeno[1,2-d]imidazole and Imidazo[1,2-a]indole Derivatives (2020)

An efficient strategy for the construction of fused imidazole derivatives through a palladium-catalyzed isocyanide insertion reaction has been accomplished. The methodology provides an operationally simple and versatile route for the synthesis of indeno[1,2-<i>d</i>]imidazole and imidazo[1,2-<i>a</i>]indole skeletons which are rarely reported. The key features of the protocol are construction of sequential C-C/C-C/C-N bonds via C(sp<sup>2</sup>)-H functionalization of imidazole at the C2- and C4-position, respectively. The compounds can be synthesized with diverse scaffolds, easily accessible starting materials, and moderate to good yields.
A Complete Histologic Approach to Gastrointestinal Biopsy From Hematopoietic Stem Cell Transplant Patients With Evidence of Transplant-Associated Gastrointestinal Thrombotic Microangiopathy (2017)

- The histologic hallmark of iTMA is endothelial cell injury that leads to hemorrhage and thrombosis of the capillaries. Histologic features include endothelial cell swelling, endothelial cell separation, perivascular mucosal hemorrhage, intraluminal schistocytes, intraluminal fibrin, intraluminal microthrombi, loss of glands, and total denudation of mucosa. Identification of features consistent with iTMA has immediate implications for clinical management that could potentially improve outcome and survival.
A new contrivance of single port and reduced port gastrectomy for gastric cancer (2017)

Background: Single-port laparoscopic gastrectomy (SPG) and reduced-port laparoscopic gastrectomy (RPG) are favorably accepted by patients with early gastric cancer because of less pain, early recovery time, and improving quality of life. However, performing SPG or RPG has some technical difficulties. This article focuses on the contrivance of SPG and RPG with operation technique and on the advantages of the combination of pneumoperitoneum and abdominal wall-lift method. Methods: Ninety-five patients with preoperative stage IA gastric cancer underwent SPG and RPG with D1+ lymphadenectomy between April 2005 and May 2016 at Hiroshima Prefectural Hospital. Thirty patients underwent SPG, and 65 underwent RPG. Results: No significant differences in amount of blood loss [10–357 (mean: 67) vs. 4–470 (mean: 63) mg, P=0.591] and operation time [218–471 (mean: 323) vs. 238–467 (mean: 320) min, P=0.595] were found between the SPG and RPG groups. No significant differences were also between the two groups in terms of post-operative complication and cosmetic results. Conclusions: SPG was safety performed with our special surgical technique, and RPG was safety and easily performed with the wide working space provided by the combination of pneumoperitoneum and abdominal wall lifting method.
Experimental Motion Analysis of Radially Rotating Beams Using High-Speed Camera and Motion Analyzer (1996)

Although strain gauges can be attached to a system for vibration analysis, wires connected to the strain gauges may disturb the system and affect the accuracy of the strain measurement. As an alternative, this work presents the use of a high-speed camera combined with a motion analyzer to study the motion of rotating flexible beams. One end of the beam is rigidly connected to a motor, while the other end is free. White stickers placed on selected points on a given beam are the reference points in a digitization process. The modes of the vibrating beams can be filmed and analyzed. The vibration parameters, such as deflection and frequency, can be obtained by using a film motion analyzer. The results show that the beam does not behave in a clamped-free or a pinned-free fashion, but instead occurs at an intermediate boundary between these two classical conditions.
Thermal deflection decoupled 6-DOF pose measurement of hexapods (2020)

Calibration is crucial for hexapods with high-accuracy positioning\ncapability. Many of these calibration procedures require measurement of\nhexapod's platform pose (position and orientation) at constant temperature.\nConsequently, thermal deflection of the hexapod's platform during pose\nmeasurements impacts the accuracy of calibrated parameters. This paper presents\na method to eliminate the impact of thermal deflection of hexapods on their\npose measurement. In this method, a reference pose is measured before each\nmeasurement of any particular pose. The measurements of reference pose are used\nto estimate thermal deflection of hexapod's legs. This is in turn used to\nestimate and correct the resulting pose error at the particular pose to be\nmeasured. The advantage of using the proposed method is demonstrated\nexperimentally by means of pose measurements of a high-precision hexapod using\na CMM.\n
Glycoside scutellarin enhanced CD-MOF anchoring for laryngeal delivery (2020)

It is essential to develop new carriers for laryngeal drug delivery in light of the lack of therapy in laryngeal related diseases. When the inhalable micron-sized crystals of <i>γ</i>-cyclodextrin metal-organic framework (CD-MOF) was utilized as dry powder inhalers (DPIs) carrier with high fine particle fraction (FPF), it was found in this research that the encapsulation of a glycoside compound, namely, scutellarin (SCU) in CD-MOF could significantly enhance its laryngeal deposition. Firstly, SCU loading into CD-MOF was optimized by incubation. Then, a series of characterizations were carried out to elucidate the mechanisms of drug loading. Finally, the laryngeal deposition rate of CD-MOF was 57.72 ± 2.19% improved by SCU, about two times higher than that of CD-MOF, when it was determined by Next Generation Impactor (NGI) at 65 L/min. As a proof of concept, pharyngolaryngitis therapeutic agent dexamethasone (DEX) had improved laryngeal deposition after being co-encapsulated with SCU in CD-MOF. The molecular simulation demonstrated the configuration of SCU in CD-MOF and its contribution to the free energy of the SCU@CD-MOF, which defined the enhanced laryngeal anchoring. In conclusion, the glycosides-like SCU could effectively enhance the anchoring of CD-MOF particles to the larynx to facilitate the treatment of laryngeal diseases.
Indium Complexes of Fluorinated Dialkoxy-Diimino Salen-like Ligands for Ring-Opening Polymerization ofrac-Lactide: How Does Indium Compare to Aluminum? (2011)

The reaction between InCl3 and {ONEtNO}K2 (1a), prepared from (CF3)2(OH)CCH2C(CH3)═N–R–N═C(CH3)CH2C(OH)(CF3)2 ({ONEtNO}H2, R = C2H4 (a); {ONCyNO}H2, R = rac-1,2-cyclohexylene (b)) and PhCH2K, gave {ONEtNO}InCl (2a). The reaction between InCl3 and 3 equiv of MeLi led to a mixture of [InMe3] and Li[InMe4], which upon further treatment with {ONRNO}H2 proligands gave the ate complexes [{ONRNO}Li]InMe2 (4a,b); the methyl complex {ONEtNO}InMe (3a) was also isolated from this reaction. Hydrocarbyl complexes {ONRNO}In(CH2SiMe3) (5a,b) were prepared cleanly from the 1:1 reactions between In(CH2SiMe3)3 and {ONRNO}H2. The solid-state molecular structures of mononuclear 2a, 3a, 4b, and 5b and of [(1a)2-(μ-H2O)]n, a distorted cubane-like core made up of four potassium atoms and two ligands, were determined. Compounds 5a,b are moderately active initiators/catalysts for the ring-opening polymerization of rac-lactide, giving polymers with controlled molecular weights and narrow polydispersities, especially in the presence of added isopropyl alcohol (1–10 equiv) as exogenous initiator. Isotactic-enriched (Pm = 0.62–0.69) PLAs were obtained from 5a, while 5b gave atactic materials. The heterobimetallic compounds 4a,b are also active and afforded slightly heterotactic-enriched PLAs (Pr = 0.57–0.62), but with broader polydispersities. Those results allowed us to discuss the initiation mechanisms according to the constitution of the systems (alkyl vs alkyl/iPrOH) and also stereoselective abilities as a function of the nature (In vs Al) and coordination environment (κ4-ONNO vs. κ2-NN) of the metal center.
Superstable Transparent Conductive Cu@Cu4Ni Nanowire Elastomer Composites against Oxidation, Bending, Stretching, and Twisting for Flexible and Stretchable Optoelectronics (2014)

Low cost and high conductivity make copper (Cu) nanowire (NW) electrodes an attractive material to construct flexible and stretchable electronic skins, displays, organic light-emitting diodes (OLEDs), solar cells, and electrochromic windows. However, the vulnerabilities that Cu NW electrodes have to oxidation, bending, and stretching still present great challenges. This work demonstrates a new Cu@Cu4Ni NW conductive elastomer composite with ultrahigh stability for the first time. Cu@Cu4Ni NWs, facilely synthesized through a one-pot method, have highly crystalline alloyed shells, clear and abrupt interfaces, lengths more than 50 μm, and smooth surfaces. These virtues provide the NW-elastomer composites with a low resistance of 62.4 ohm/sq at 80% transparency, which is even better than the commercial ITO/PET flexible electrodes. In addition, the fluctuation amplitude of resistance is within 2 ohm/sq within 30 days, meaning that at ΔR/R0 = 1, the actual lifetime is estimated to be more than 1200 days. Neither the conductivity nor the performances of OLED with elastomers as conductive circuits show evident degradation during 600 cycles of bending, stretching, and twisting tests. These high-performance and extremely stable NW elastomeric electrodes could endow great chances for transparent, flexible, stretchable, and wearable electronic and optoelectronic devices.
The dependence of the solid state structures of bisparaphenylene-(3n+ 4)-crown-n ethers upon macrocyclic ring size (1987)

X-Ray crystallography on the free BPP(3n+4)Cn ethers where n= 7,8,10,11, and 12 reveals a conformational dependence for the macrocycles which is reflected in their cavity sizes, with a maximum for n= 10, and in the relative orientations of the two hydroquinol rings, almost orthogonal for n= 7 and parallel or nearly parallel for n= 8,10,11, and 12, with respect to each other.
Silicon carbide surface structure investigated by synchrotron radiation-based x-ray diffraction (2003)

We use synchrotron radiation based x-ray diffraction at grazing incidence to study the atomic structure of Si-rich β-SiC(100) 3×2 surface reconstruction. The latter includes three different Si atomic planes, in qualitative agreement with the theoretical two adlayers asymmetric dimer model. The measurements provide an accurate determination of the atomic bond, indicating asymmetric Si dimers in the first plane, and an alternating long and short Si dimers subsurface organization in the second atomic plane responsible for the lack of dimers buckling in the first plane, unlike corresponding silicon or germanium surfaces.
Methylene Blue for Burn-Induced Vasoplegia (2014)

We report the use of a single dose of methylene blue in a patient with burn-induced vasoplegia refractory to fluids, vasopressors, and steroids. Administration of methylene blue allowed for cessation of epinephrine infusion within 2 hours of administration, and reduction in excessive fluid resuscitation. The patient's clinical course continued for 2 months and was complicated by severe acute respiratory distress syndrome, pneumonia, septic shock, poor skin graft adherence, renal failure requiring continuous renal replacement therapy, cutaneous mucormycosis, and ultimately, withdrawal of care and death. Despite the eventual outcome, this is the longest reported survival following methylene blue administration for vasoplegia secondary to burn injury.
Threshold effects and cellular recognition. Progress report (1980)

In the first year we focused on developing the techniques required for the successful incorporation of synthetic glycolipids into cells. To these ends a new water-soluble spacer group (8-amino-3-6-dioxaoctanoic acid) was developed and incorporated into the cholesterol based synthetic glycolipids. These glycolipids could be incorporated into liposomes, rendering them susceptible to aggregation by the appropriate lectin. They also allowed us to define the minimal distance between the sugar moiety and membrane required for agglutination. Finally and most importantly, we were able to functionally incorporate these new glycolipids in cells and render them agglutinable with the appropriate lectins. Functional incorporation does not occur with glycolipids bearing hydropholic spacer groups. We are now in a position to begin using the new glycolipids to answer questions about the roles of cell surface sugars in cellular recognition, which is the subject of this renewal proposal.
Influence of Sulfur-Containing Compounds on Nitrate-Induced Rapid Detinning in Acid Fruit Cans. (1997)

Serious problems arise in the rapid detinning of plain tinplate cans, particularly when the cans contain are tropical fruit with high nitrate concentrations poses.An investigation found that rapid detinning does not occur in presence of high nitrate concentrations, because the tin sulfide film formed on the tinplate surface surpresses detinning.We confirmed that sulfur forming tin sulfide originates from cans contents, i.e. sulfur-containing compounds that determine fruit flavor and taste. Sulfur-containing compounds such as L-cysteine are particularly thermally unstable and decomposed by heat treatment. Tin sulfide film surpresses detinning, and tends to cause iron dissolution reaction, meaning that due care must be exercised.
Proteomic mechanisms of drug resistance in Candida cell membrane fractions (2015)

Poster presented at the International Association for Dental Research, 92nd General Session, Cape Town, South Africa, 25-28 June 2014.
Signal analysis for the actinic full-field EUVL mask blank inspection system (2008)

We have developed an actinic full-field inspection system to detect multilayer phase defect with dark field imaging. With this system, programmed phase defects on a mask blank were observed. The system can detect phase defects caused by a 1.5 nm high and 60 nm wide protrusion on a multilayer surface. Background intensity and signal to background ratio (SBR) of the observed defect images are analyzed with simulation. The background intensities were calculated with the model that it is generated by light scattered from mask surface roughness. The result indicates that the larger outer NA (numerical aperture) leads to an increase in the background intensity. In this correlation of NA with the background intensity, the calculation and experimental results correspond well. The defect images were simulated using the point spread function (PSF) of flare generated by mirror surface roughness employing Fourier technique. The SBRs of simulated defect images corresponded well with the SBRs of the observed images. These results support the calculation and simulation models are proper.
Application of Adaptive Filters in Sensor Array Processing for Underwater Applications (2019)

This paper aims to apply adaptive filtering algorithms in sensor array processing for underwater surveillance and detection systems with linear arrays. Adaptive filters are iterative in nature and continuously update the filter taps to minimize the error signal based upon certain criterion. Adaptive filters are used in beamforming to place the main beam in the direction of desired signal and place nulls in the direction of unwanted signals. Adaptive filters are also used in spectral analysis of acoustic signals for background noise cancellation. This paper evaluates the performance of three adaptive filtering algorithms with respect to sensor array design parameters i.e. number of sensors, sensor spacing, number of incident signals and their angular separation. The three adaptive filtering algorithms namely least mean square (LMS), normalized LMS (NLMS), and sample matrix inversion (SMI) have been compared in the context of linear array beamforming. The paper provides detailed discussions on the simulation results of these adaptive algorithms in terms of convergence speed, beamwidth, null depths and maximum side lobe levels. In addition the paper illustrates a practical example of applying adaptive filters in underwater sensor array processing systems for detection of target's acoustic signatures.
Time-varying compensation can yield no improvement for 1-sensitivity minimization (1988)

It is shown that time-varying compensation gives no improvement over time-invariant compensation for the ti-sensitivity minimization problem.
Efficacité d'une Excitation Bifréquentielle en Thrombolyse Purement Ultrasonore (2010)

National audience