gebhart/patrepeval huggingface dataset:
Supplementary Figure 4 from MYC-Driven Tumorigenesis Is Inhibited by WRN Syndrome Gene Deficiency (2023)

&lt;p&gt;PDF file - 114K&lt;/p&gt;
On the relationship between functional hearing and depression (2015)

Data support an association between functional hearing and depression that is stronger in the younger participants (40-49 years old) and for milder depression. The association was not alleviated by hearing-aid usage, but was partially confounded by other physical health problems.
The Uses and Misuses of Quantum Jargon (2011)

This letter has been simultaneously published in EdgeScience magazine (7, April–June 2011), also published by the Society for Scientific Exploration.
Current Approaches for Improving Intratumoral Accumulation and Distribution of Nanomedicines (2015)

The ability of nanoparticles and macromolecules to passively accumulate in solid tumors and enhance therapeutic effects in comparison with conventional anticancer agents has resulted in the development of various multifunctional nanomedicines including liposomes, polymeric micelles, and magnetic nanoparticles. Further modifications of these nanoparticles have improved their characteristics in terms of tumor selectivity, circulation time in blood, enhanced uptake by cancer cells, and sensitivity to tumor microenvironment. These "smart" systems have enabled highly effective delivery of drugs, genes, shRNA, radioisotopes, and other therapeutic molecules. However, the resulting therapeutically relevant local concentrations of anticancer agents are often insufficient to cause tumor regression and complete elimination. Poor perfusion of inner regions of solid tumors as well as vascular barrier, high interstitial fluid pressure, and dense intercellular matrix are the main intratumoral barriers that impair drug delivery and impede uniform distribution of nanomedicines throughout a tumor. Here we review existing methods and approaches for improving tumoral uptake and distribution of nano-scaled therapeutic particles and macromolecules (i.e. nanomedicines). Briefly, these strategies include tuning physicochemical characteristics of nanomedicines, modulating physiological state of tumors with physical impacts or physiologically active agents, and active delivery of nanomedicines using cellular hitchhiking.
On the estimation of atmospheric turbulence layers for AO systems (2013)

In current and next generation of ground telescopes, Adaptive Optics (AO) are employed to overcome the detrimental effects induced by the presence of atmospheric turbulence, that strongly affects the quality of data transmission and limits the actual resolution of the overall system. The analysis as well as the prediction of the turbulent phase affecting the light wavefront is therefore of paramount importance to guarantee the effective performance of the AO solution. In this work, a layered model of turbulence is proposed, based on the definition of a Markov-Random-Field whose parameters are determined according to the turbulence statistics. The problem of turbulence estimation is formalized within the stochastic framework and conditions for the identifiability of the turbulence structure (numbers of layers, energies and velocities) are stated. Finally, an algorithm to allow the layer detection and characterization from measurements is designed. Numerical simulations are used to assess the proposed procedure and validate the results, confirming the validity of the approach and the accuracy of the detection.
Mechanism of in Vitro Expansion of Long DNA Repeats:  Effect of Temperature, Repeat Length, Repeat Sequence, and DNA Polymerases (2001)

Studies of sequence repeat expansions from duplexes consisting of DNA repeat sequences greater than three bases are currently lacking. These studies are needed in order to gain a better understanding of DNA expansions in general and as a first step in understanding expansions of longer sequence repeats that have been implicated in human diseases. We have undertaken an in vitro study of tetranucleotide, hexanucleotide, and octanucleotide repeat expansions from short DNA duplexes using Taq DNA polymerase. Expansions of hexanucleotide repeats were also studied with the Klenow fragment of DNA polymerase I and with T4 DNA polymerase. Studies with Taq DNA polymerase show that expansions occur more readily as the length of the repeat sequence decreases but are generally more efficient at reaction temperatures closer to the melting point of the starting duplex. A mechanism for the observed expansions with Taq DNA polymerase is proposed that does not invoke strand slippage or DNA structure. Studies at 37 °C with Klenow pol I and T4 DNA polymerase indicate that the template-switching and/or strand-displacement activities of the polymerases used can play a major role in the apparent in vitro expansions of short repetitive DNA duplexes.
Levine's Isomorph Dictionary (1972)

Among word buffs, 1971 will undoubtedly be remembered as the year that the Compact Edition of the Oxford English Dictionary was published, making this monumental work available at one-third the price and one-sixth the bulk of the original. An exceedingly useful lexicographic tool has been placed in the hands of many who formerly had to make a trip to the library to consult it. By contrast, one of the least-heralded publishing events of 1971 was the appearance of Jack Levine's A List of Pattern Words of Lengths Two Through Nine. Nevertheless, I predict that the Levine dictionary may have a greater impact than the COED on word buffs. The information in the COED has been available in the OED for decades, but Levine's dictionary enables the logologist to view Webster's Unabridged in an entirely new light: specifically, it groups together all words with the same underlying pattern, such as EXCESS and BAMBOO (and, in fact, 23 rarer words also having the letter-pattern abcadd). Furthermore, the COED costs $75, but the Levine dictionary may be obtained free while the limited supply lasts.
Epigenetic Reprogramming of TGF-β Signaling in Breast Cancer (2019)

The Transforming Growth Factor-β (TGF-β) signaling pathway has a well-documented, context-dependent role in breast cancer development. In normal and premalignant cells, it acts as a tumor suppressor. By contrast, during the malignant phases of breast cancer progression, the TGF-β signaling pathway elicits tumor promoting effects particularly by driving the epithelial to mesenchymal transition (EMT), which enhances tumor cell migration, invasion and ultimately metastasis to distant organs. The molecular and cellular mechanisms that govern this dual capacity are being uncovered at multiple molecular levels. This review will focus on recent advances relating to how epigenetic changes such as acetylation and methylation control the outcome of TGF-β signaling and alter the fate of breast cancer cells. In addition, we will highlight how this knowledge can be further exploited to curb tumorigenesis by selective targeting of the TGF-β signaling pathway.
ChemInform Abstract: A Ternary Complex Reagent for an Asymmetric Reaction of Lithium Ester Enolates with Imines. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Quality of Life after Surgery for Recurrent Otitis Media in a Randomized Controlled Trial (2014)

QOL in children with RAOM improves with time when the subjects are closely followed. Tympanostomy with adenoidectomy does not provide any additional QOL benefit for children with RAOM, even though these operations are effective in preventing further otitis media episodes.
Human Photosynthesis and Alzheimer’s Disease (2012)

More than 100 years have passed by since the first description of AD by Alois Alzheimer; however the patients are dying in the same way. Our discovery of the hitherto unknown capacity of the human body to split the water molecule breaks the paradigm. In accordance with our experience of 21 years, the signs and symptoms of AD are compatible with a generalized failure of the CNS; therefore AD is an energy problem, not a biomass trouble. In this work we are presenting the basis and results of our completely new treatment whose principles are grounded in a very different physiology: the main source of energy of the human body is water not food, in other words: the main source of energy of the CNS is the water located in the ventricles and subarachnoid space, and not through the blood vessels. Glucose is just a source of biomass, and therefore it must be absorbed from the gastrointestinal tract and then it needs to be transported to the different tissues in our organism by the blood vessels but eukaryotic cell uses glycans only as building blocks, surprisingly energy is taken from water, a very different and unknown concept. Energy comes in an unsuspected highly proportion (99%) from a similar process in plants: the water dissociation, a reaction that we appointed as human photosynthesis by their analogies with the photosynthesis of the plants. The capacity of our body to take energy from water begin to diminish at 26 years old, at rate of approximately 10 % each decade and after fifties it goes into free fall. This seems to be the natural history, however several factors are able to turning down the human photosynthesis levels, as alcohol, iron supplements, high fructose syrup, hormones, pesticides, herbicides, medical compounds with a high apparent distribution volume like antidepressants, old age, diabetes, trauma; contaminated water, etc. When the energy released by our photosynthesis system is comprised in enough amount and time, chaos sooner or later overcome. With the medical enhancement of the natural capacity of our body to split and back-bonding the water molecule, the recovery of AD patients are astonishing. In this brief presentation we will present some examples of the remarkable improvement in patients with AD treated at our Human Photosynthesis Study Center.
Broadening the Cloaking Bandwidth with Non-Foster Metasurfaces (2013)

We introduce the concept and practical design of broadband, ultrathin cloaks based on non-Foster, negatively capacitive metasurfaces. By using properly tailored, active frequency-selective screens conformal to an object, within the realm of a practical realization, we show that it is possible to drastically reduce the scattering over a wide frequency range in the microwave regime, orders of magnitude broader than any available passive cloaking technology. The proposed active cloak may impact not only invisibility and camouflaging, but also practical antenna and sensing applications.
[Research on in vivo metabolites of Longxue Tongluo Capsules by liquid chromatography coupled with hybrid ion trap/time-of-flight mass spectrometry]. (2021)

Longxue Tongluo Capsules(LTC) has good efficacy against blood stasis syndrome during the recovery period of ischemic stroke. Its main active ingredient is the phenolic extract of Chinese dragon's blood. In our previous study, the primary mass fragmentation pathways of phenolic derivatives from LTC were clarified. Herein, the metabolites in rat plasma were characterized following the oral administration of loureirin A and loureirin C using liquid chromatography coupled with hybrid ion trap/time-of-flight mass spectro-metry(LC-IT-TOF-MS), with 18 and 55 metabolites identified, respectively. On this basis, with the help of the obtained accurate molecular weight, characteristic fragment ions, reference comparison, combined with LTC database and natural products database self-created in our group, 18 prototypes and 106 metabolites were tentatively identified in rat plasma after oral gavage of LTC at a dose of 500 mg·kg~(-1). Glucuronidation, sulfonation, and methylation were major biotransformation pathways of LTC. This study preliminarily clarified the LTC constituents absorbed into blood and laid the foundation for clarifying the effective substances of LTC.
Relaxation to a Phase-Locked Equilibrium State in a One-Dimensional Bosonic Josephson Junction (2018)

We present an experimental study on the nonequilibrium tunnel dynamics of two coupled one-dimensional Bose-Einstein quasicondensates deep in the Josephson regime. Josephson oscillations are initiated by splitting a single one-dimensional condensate and imprinting a relative phase between the superfluids. Regardless of the initial state and experimental parameters, the dynamics of the relative phase and atom number imbalance shows a relaxation to a phase-locked steady state. The latter is characterized by a high phase coherence and reduced fluctuations with respect to the initial state. We propose an empirical model based on the analogy with the anharmonic oscillator to describe the effect of various experimental parameters. A microscopic theory compatible with our observations is still missing.
Fingerprint Reconstruction: From Minutiae to Phase (2010)

Fingerprint matching systems generally use four types of representation schemes: grayscale image, phase image, skeleton image, and minutiae, among which minutiae-based representation is the most widely adopted one. The compactness of minutiae representation has created an impression that the minutiae template does not contain sufficient information to allow the reconstruction of the original grayscale fingerprint image. This belief has now been shown to be false; several algorithms have been proposed that can reconstruct fingerprint images from minutiae templates. These techniques try to either reconstruct the skeleton image, which is then converted into the grayscale image, or reconstruct the grayscale image directly from the minutiae template. However, they have a common drawback: Many spurious minutiae not included in the original minutiae template are generated in the reconstructed image. Moreover, some of these reconstruction techniques can only generate a partial fingerprint. In this paper, a novel fingerprint reconstruction algorithm is proposed to reconstruct the phase image, which is then converted into the grayscale image. The proposed reconstruction algorithm not only gives the whole fingerprint, but the reconstructed fingerprint contains very few spurious minutiae. Specifically, a fingerprint image is represented as a phase image which consists of the continuous phase and the spiral phase (which corresponds to minutiae). An algorithm is proposed to reconstruct the continuous phase from minutiae. The proposed reconstruction algorithm has been evaluated with respect to the success rates of type-I attack (match the reconstructed fingerprint against the original fingerprint) and type-II attack (match the reconstructed fingerprint against different impressions of the original fingerprint) using a commercial fingerprint recognition system. Given the reconstructed image from our algorithm, we show that both types of attacks can be successfully launched against a fingerprint recognition system.
Retracted: Exosomal circRNA derived from gastric tumor promotes white adipose browning by targeting the miR‐133/PRDM16 pathway (2018)

Cancer-related cachexia is a metabolic syndrome characterized by a wasting disorder of adipose and skeletal muscle and is accompanied by body weight loss and systemic inflammation. The treatment options for cancer cachexia are limited, and the molecular mechanism remains poorly understood. Circular RNAs (circRNAs) are a novel family of endogenous noncoding RNAs that have been proposed to regulate gene expression in mammals. Exosomes are small vesicles derived from cells, and recent studies have shown that circRNAs are stable in exosomes. However, little is known about the biological role of circRNAs in exosomes. In our study, we showed that circRNAs in plasma exosomes have specific expression features in gastric cancer (GC), and ciRS-133 is linked with the browning of white adipose tissue (WAT) in GC patients. Exosomes derived from GC cells deliver ciRS-133 into preadipocytes, promoting the differentiation of preadipocytes into brown-like cells by activating PRDM16 and suppressing miR-133. Moreover, knockdown of ciRS-133 reduced cancer cachexia in tumor-implanted mice, decreasing oxygen consumption and heat production. Thus, exosome-delivered circRNAs are involved in WAT browning and play a key role in cancer-associated cachexia.
Impact of yeast and lactic acid bacteria on mastitis and milk microbiota composition of dairy cows (2020)

This experiment was conducted to evaluate the impact of yeast and lactic acid bacteria (LAB) on mastitis and milk microbiota composition of dairy cows. Thirty lactating Holstein cows with similar parity, days in milk were randomly assigned to five treatments, including: (1) Health cows with milk SCC < 500,000 cells/mL, no clinical signs of mastitis were found, fed basal total mixed ration (TMR) without supplementation (H); (2) Mastitis cows with milk SCC > 500,000 cells/mL, fed basal TMR without supplementation (M); (3) Mastitis cows fed basal TMR supplemented with 8 g day<sup>-1</sup> yeast (M + Y); (4) Mastitis cows fed basal TMR supplemented with 8 g day<sup>-1</sup> LAB (M + L); (5) Mastitis cows (milk SCC > 500,000 cells/mL) fed basal TMR supplemented with 4 g day<sup>-1</sup> yeast and 4 g day<sup>-1</sup> LAB (M + Y + L). Blood and milk sample were collected at day 0, day 20 and day 40. The results showed efficacy of probiotic: On day 20 and day 40, milk SCC in H, M + Y, M + L, M + Y + L was significantly lower than that of M (P < 0.05). Milk concentration of TNF-α, IL-6 and IL-1β in M + Y + L were significantly reduced compared with that of M on day 40 (P < 0.05). Milk Myeloperoxidase (MPO) and N-Acetyl-β-D-Glucosaminidase (NAG) activity of M + Y, M + L, M + L + Y were lower than that of M on day 40 (P < 0.05). At genus level, Staphylococcus, Chryseobacterium and Lactococcus were dominant. Supplementation of LAB decreased abundance of Enterococcus and Streptococcus, identified as mastitis-causing pathogen. The results suggested the potential of LAB to prevent mastitis by relieving mammary gland inflammation and regulating milk microorganisms.
Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals (2022)

Integrating genetic information with metabolomics has provided new insights into genes affecting human metabolism. However, gene-metabolite integration has been primarily studied in individuals of European Ancestry, limiting the opportunity to leverage genomic diversity for discovery. In addition, these analyses have principally involved known metabolites, with the majority of the profiled peaks left unannotated. Here, we perform a whole genome association study of 2,291 metabolite peaks (known and unknown features) in 2,466 Black individuals from the Jackson Heart Study. We identify 519 locus-metabolite associations for 427 metabolite peaks and validate our findings in two multi-ethnic cohorts. A significant proportion of these associations are in ancestry specific alleles including findings in APOE, TTR and CD36. We leverage tandem mass spectrometry to annotate unknown metabolites, providing new insight into hereditary diseases including transthyretin amyloidosis and sickle cell disease. Our integrative omics approach leverages genomic diversity to provide novel insights into diverse cardiometabolic diseases.
Preparation and Use of Tethered Ligands as Biomaterials and Tools for Cell Biology (2003)

The immobilization of biomolecules to various supports has been an important research area for many years. Molecules such as heparin (1,2), as well as various enzymes (3,4), antibodies (5,6), and adhesion ligands (7), have been bound to such supports as silicon or glass, agarose gels, polyethylene oxide (PEO) gels, poly(vinyl alcohol) (PVA) gels, and polymer surfaces. These studies have had important applications in the creation of antithrombogenic surfaces for blood contact, affinity chromatography, and tissue growth and regeneration.
A Survey on Cellular-connected UAVs: Design Challenges, Enabling 5G/B5G\n Innovations, and Experimental Advancements (2020)

As an emerging field of aerial robotics, Unmanned Aerial Vehicles (UAVs) have\ngained significant research interest within the wireless networking research\ncommunity. As soon as national legislations allow UAVs to fly autonomously, we\nwill see swarms of UAV populating the sky of our smart cities to accomplish\ndifferent missions: parcel delivery, infrastructure monitoring, event filming,\nsurveillance, tracking, etc. The UAV ecosystem can benefit from existing 5G/B5G\ncellular networks, which can be exploited in different ways to enhance UAV\ncommunications. Because of the inherent characteristics of UAV pertaining to\nflexible mobility in 3D space, autonomous operation and intelligent placement,\nthese smart devices cater to wide range of wireless applications and use cases.\nThis work aims at presenting an in-depth exploration of integration synergies\nbetween 5G/B5G cellular systems and UAV technology, where the UAV is integrated\nas a new aerial User Equipment (UE) to existing cellular networks. In this\nintegration, the UAVs perform the role of flying users within cellular\ncoverage, thus they are termed as cellular-connected UAVs (a.k.a. UAV-UE,\ndrone-UE, 5G-connected drone, or aerial user). The main focus of this work is\nto present an extensive study of integration challenges along with key 5G/B5G\ntechnological innovations and ongoing efforts in design prototyping and field\ntrials corroborating cellular-connected UAVs. This study highlights recent\nprogress updates with respect to 3GPP standardization and emphasizes\nsocio-economic concerns that must be accounted before successful adoption of\nthis promising technology. Various open problems paving the path to future\nresearch opportunities are also discussed.\n
The verb phrase (2003)

The verb phrase has been of central importance in contact linguistics. While it is true that no particular set of syntactic features can identify a language as having undergone restructuring without reference to its sociolinguistic history, it is also true that the structure of the verb phrase has been of primary importance in distinguishing creole varieties (e.g. Jamaican) from non-creole varieties (e.g. Caymanian English) of the same lexical base. In the Caribbean, the non-creoles have their European system of tense marking (e.g. auxiliary verbs and verbal inflections) more or less intact, whereas the creoles have a radically different way of dealing with tense and aspect. With few exceptions, basilectal Atlantic creole verbs have no inflections; instead, they are preceded by particles indicating tense (the time of an action's occurrence) or aspect (referring to its duration, recurrence, completion, etc.). These often have the outer form of auxiliary verbs from the lexical source language (which occupy a similar position and usually serve a similar function), but semantically and syntactically they are much more like the preverbal tense and aspect markers in many of the creoles' African substrate languages.
Effective linearization of broadband amplifiers by use of cascade compensation between the amplifier stages (2003)

A strategy is described for finding cascades of basic transistor circuits that are able to compensate for quadratic and/or cubic nonlinearities in a compact two-state amplifier arrangement. Such amplifiers are able to achieve low nonlinearity combined with low-power consumption and relatively high gain. The strategy is explained for bipolar transistors as well as for field-effect transistors. Examples are given.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>