gebhart/patrepeval huggingface dataset:
Skeletrophin, a Novel RING Molecule Controlled by the Chromatin Remodeling Complex, Is Downregulated in Malignant Melanoma (2005)

Recent experiments have revealed that aberrant functionality of the chromatin remodeling complex is related to tumorigenicity in various malignant tumors. Skeletrophin is an actin-binding cytoskeleton-related molecule, which is induced by the overexpression of truncated human SWI1 (SMARCF1). Human SWI1 is a sub-unit of the chromatin remodeling complex and binds chromatin through its ARID (AT-rich interactive domain). Truncated SWI1 lacks one of the two glucocorticoid-receptor binding domains and inhibits the intact human SWI1 in a dominant negative manner. Skeletrophin, was therefore identified as a candidate molecule for the indication of change to a malignant phenotype due to the aberrant function of the chromatin remodeling complex. Surprisingly, the skeletrophin gene is located in 1p36.32, where the putative tumor suppressor gene of cutaneous malignant melanoma has long been postulated to be on. Cutaneous malignant melanoma is a highly aggressive tumor. To overcome the clinical problem of malignant melanoma and highly invasive and metastatic activity, it is important to unravel the molecular mechanism responsible for melanoma progression. Recent studies including those from our laboratories have elucidated that skeletrophin is a novel RING-HC type ubiquitin ligase and that the ubiquitin ligase pathway mediated by skeletrophin acts to oppose melanoma cell invasion. Here, we summarize the characterization of skeletrophin, with emphasis on its biological activity, the disruption of which is linked with melanoma progression.
Robust and Accurate 3D Head Pose Estimation through 3DMM and Online Head Model Reconstruction (2017)

Accurate and robust 3D head pose estimation is important for face related analysis. Though high accuracy has been achieved by previous works based on 3D morphable model (3DMM), their performance drops with extreme head poses because such models usually only represent the frontal face region. In this paper, we present a robust head pose estimation framework by complementing a 3DMM model with an online 3D reconstruction of the full head providing more support when handling extreme head poses. The approach includes a robust online 3DMM fitting step based on multi-view observation samples as well as smooth and face-neutral synthetic samples generated from the reconstructed 3D head model. Experiments show that our framework achieves state-of-the-art pose estimation accuracy on the BIWI dataset, and has robust performance for extreme head poses when tested on natural interaction sequences.
Phosphorescent Platinum(II) Complexes Derived from Multifunctional Chromophores:  Synthesis, Structures, Photophysics, and Electroluminescence (2006)

The synthesis and structural, photophysical, electrochemical, and electroluminescent properties of a novel class of trifunctional Pt(II) cyclometalated complexes are reported in which the hole-transporting triarylamine, electron-transporting oxadiazole, and electroluminescent metal components are integrated into a single molecule. These neutral metal chelates display good thermal stability (>250 degrees C under N2) and morphological stability. All of them exhibit intense ligand-centered fluorescence and phosphorescence in fluid solutions at room temperature, but the emission spectra become largely dominated by triplet emission bands in CH2Cl2 glass at 77 K. Substituents with different electronic properties were introduced into the bipolar cyclometalating ligands to fine-tune the absorption and emissive characteristics of the compounds, and the results were correlated with theoretical calculations using density functional theory. A comparison of the photophysics and electrochemistry of our multifunctional systems to those only derived from each of the constituent components was also made and discussed. These Pt complexes can be vacuum-sublimed and applied as emissive dopants for the fabrication of vapor-deposited electrophosphorescent organic light-emitting devices (OLEDs), which generally exhibit good device performance with efficiencies up to 3.6%, 11.0 cd A-1, and 5.8 lm W-1. While the electroluminescence energy resembles that recorded in fluid solutions for these Pt emitters, these monochromatic OLEDs can emit tunable colors by varying the aryl ring substituents and the level of doping. Saliently, single dopant white-light electroluminescence, triggered by the simultaneous fluorescence/phosphorescence emission of the metal complexes and a variation of applied driving voltages, has also been realized based on some of these multifunctional complexes with peak electrophosphorescence efficiencies of 6.8 cd A-1 and 2.6%.
Fast Terrain Classification Using Variable-Length Representation for Autonomous Navigation (2007)

We propose a method for learning using a set of feature representations which retrieve different amounts of information at different costs. The goal is to create a more efficient terrain classification algorithm which can be used in real-time, onboard an autonomous vehicle. Instead of building a monolithic classifier with uniformly complex representation for each class, the main idea here is to actively consider the labels or misclassification cost while constructing the classifier. For example, some terrain classes might be easily separable from the rest, so very simple representation will be sufficient to learn and detect these classes. This is taken advantage of during learning, so the algorithm automatically builds a variable-length visual representation which varies according to the complexity of the classification task. This enables fast recognition of different terrain types during testing. We also show how to select a set of feature representations so that the desired terrain classification task is accomplished with high accuracy and is at the same time efficient. The proposed approach achieves a good trade-off between recognition performance and speedup on data collected by an autonomous robot.
Partial Resuscitative Endovascular Balloon Occlusion of the Aorta (P-REBOA) in a Pig Model (Sus scrofa) (2015)

Abstract : Background: Partial REBOA (P-REBOA) may permit longer periods of occlusion by allowing some degree of distal perfusion. However the ability of this procedure to limit exsanguination is unclear. We evaluated the impact of P-REBOA on immediate survival in a highly lethal swine liver injury model. Methods: Fifteen Yorkshire-cross swine were anesthetized, instrumented, splenectomized, and subjected to 30 liver amputation. Coagulopathy was created through hemodilution. Randomized swine received no intervention (control), P-REBOA, or complete REBOA (C-REBOA). Central mean arterial pressure (cMAP), carotid blood flow, and blood loss were recorded. Balloons remained inflated in the P-REBOA and C-REBOA groups for 90m followed by graded deflation. The study ended at 180m from onset of hemorrhage or death of the animal. Survival analysis was performed. Results: Survival times in the control, P-REBOA, and C-REBOA groups were, 2521, 8640, and 16320m, respectively (p0.001). There was no difference in blood loss among the groups. P-REBOA maintained near-baseline carotid blood flow and cMAP, while C-REBOA generated extreme cMAP and prolonged supraphysiologic carotid blood flow. Both experimental groups experienced profound decreases in cMAP following deflation. Conclusions: With severe ongoing hemorrhage, P-REBOA increased survival time while maintaining cMAP and carotid flow at physiologic levels.
The Complete Sequence of 340 kb of DNA around the Rice Adh1–Adh2 Region Reveals Interrupted Colinearity with Maize Chromosome 4 (2000)

A 2.3-centimorgan (cM) segment of rice chromosome 11 consisting of 340 kb of DNA sequence around the alcohol dehydrogenase Adh1 and Adh2 loci was completely sequenced, revealing the presence of 33 putative genes, including several apparently involved in disease resistance. Fourteen of the genes were confirmed by identifying the corresponding transcripts. Five genes, spanning 1.9 cM of the region, cross-hybridized with maize genomic DNA and were genetically mapped in maize, revealing a stretch of colinearity with maize chromosome 4. The Adh1 gene marked one significant interruption. This gene mapped to maize chromosome 1, indicating a possible translocation of Adh1 after the evolutionary divergence leading to maize and sorghum. Several other genes, most notably genes similar to known disease resistance genes, showed no cross-hybridization with maize genomic DNA, suggesting sequence divergence or absence of these sequences in maize, which is in contrast to several other well-conserved genes, including Adh1 and Adh2. These findings indicate that the use of rice as the model system for other cereals may sometimes be complicated by the presence of rapidly evolving gene families and microtranslocations. Seven retrotransposons and eight transposons were identified in this rice segment, including a Tc1/Mariner-like element, which is new to rice. In contrast to maize, retroelements are less frequent in rice. Only 14.4% of this genome segment consist of retroelements. Miniature inverted repeat transposable elements were found to be the most frequently occurring class of repetitive elements, accounting for 18.8% of the total repetitive DNA.
Methylation and Demethylation in Cobaltabis(dicarbollide) Derivatives (2003)

B(8)−R and B(8‘)−R (R = alkyl) disubstituted derivatives of the cobaltabis(dicarbollide) anion [3,3‘-Co(C2B9H11)2]- are reported. The synthesis was achieved by application of a modified Kumada reaction to produce B−C bonds. Molecules containing B(8)−C and B−O bonds are also generated, and interestingly, a high-yield intramolecular oxodemethylation is observed for the first time in boron cluster chemistry. It is also shown that the 11B NMR spectrum of Cs[3,3‘-Co(C2B9H11)2] derivatives is the result of the addition of the individual halves.
Frequency Shift Chirp Modulation: The LoRa Modulation (2017)

Low power wide area networks (LPWAN) are emerging as a new paradigm, especially in the field of Internet of Things (IoT) connectivity. LoRa is one of the LPWAN and it is gaining quite a lot of commercial traction. The modulation underlying LoRa is patented and has never been described theoretically. The aim of this letter is to give the first rigorous mathematical signal processing description of the modulation and demodulation processes. We provide as well a theoretical derivation of the optimum receiver entailing a low-complexity demodulation process, resorting to the Fast Fourier Transform. We compare then the performance of the LoRa modulation and the frequency-shift keying modulation both in an additive white gaussian noise channel and a frequency selective channel, showing the superiority of the LoRa modulation in the frequency selective channel. The results of this letter will enable a further assessment of the LoRa based networks, much more rigorous than what has been done until now.
High speed, high capacity ATM optical switches for future telecommunication transport networks (1996)

This paper describes the work carried out in the RACE Project R2039 ATMOS (asynchronous transfer mode optical switching). The project is briefly illustrated, together with its main goal: to develop and assess concepts and technology suitable for optical fast packet switching. The project's technical approach consisted in the exploitation of the space and wavelength domains for fast routing and buffering: The major achievements are then reported. Four different switch architecture concepts have been proposed, investigated and developed, all based on a high speed optical routing matrix electrically controlled at lower speed. The basic optical key components and subsystems (wavelength converters, space switches and optical buffers) are described in detail, with the outstanding results obtained and the corresponding projected performance. In particular, system demonstration of wavelength conversion at 10 and 20 Gb/s has been realized, to show the usefulness of the ATMOS technology both to implement optimized high performance optical packet-switching fabrics as well as transparent optical circuit-routing nodes. Four rack-mounted, reduced size demonstrators of basic switching matrices have been designed and implemented scalable to real system sizes. The obtained good results in terms of bit error rate and hardware integration are reported, showing that ATM switches are feasible with state of-the-art optical technology.
Association of sugar-sweetened beverage intake at 18 months and 5 years of age with adiposity outcomes at 6 years of age: the Singapore GUSTO mother-offspring cohort (2019)

Consumption of sugar-sweetened beverages (SSB) by infants and young children are less explored in Asian populations. The Growing Up in Singapore Towards healthy Outcomes cohort study examined associations between SSB intake at 18 months and 5 years of age, with adiposity measures at 6 years of age. We studied Singaporean infants/children with SSB intake assessed by FFQ at 18 months of age (n 555) and 5 years of age (n 767). The median for SSB intakes is 28 (interquartile range 5·5–98) ml at 18 months of age and 111 (interquartile range 57–198) ml at 5 years of age. Association between SSB intake (100 ml/d increments and tertile categories) and adiposity measures (BMI standard deviation scores (sd units), sum of skinfolds (SSF)) and overweight/obesity status were examined using multivariable linear and Poisson regression models, respectively. After adjusting for confounders and additionally for energy intake, SSB intake at age 18 months were not significantly associated with later adiposity measures and overweight/obesity outcomes. In contrast, at age 5 years, SSB intake when modelled as 100 ml/d increments were associated with higher BMI by 0·09 (95 % CI 0·02, 0·16) sd units, higher SSF thickness by 0·68 (95 % CI 0·06, 1·44) mm and increased risk of overweight/obesity by 1·2 (95 % CI 1·07, 1·23) times at age 6 years. Trends were consistent with SSB intake modelled as categorical tertiles. In summary, SSB intake in young childhood is associated with higher risks of adiposity and overweight/obesity. Public health policies working to reduce SSB consumption need to focus on prevention programmes targeted at young children.
Wearable sensorimotor enhancer for a fingertip based on stochastic resonance (2011)

This paper reports the initial experimental results of a wearable sensorimotor enhancer for a fingertip. A short-time exposure of tactile receptors to sub-sensory white-noise vibration is known to improve the tactile sensitivity. This phenomenon, called “noise-enhanced tactile sensation” or stochastic resonance (SR) in the somatosensory system, is expected to enhance the sense of touch when white-noise vibration is applied to a fingertip, and thereby improve associated motor skills. A prototype sensorimotor enhancer has been developed in this research. This wearable device is to stimulate tactile receptors by applying vibration from a compact lead zirconate titanate (PZT) piezoelectric stack actuator attached at the radial side of the fingertip. This design keeps the palmar region free and maintains the wearer's manipulability. Sensory and motor tests have been conducted for health subjects to confirm the efficacy of the device. Statistical significance has been observed in most of the tests.
Suppression of activated Let-60 ras protein defines a role of Caenorhabditis elegans Sur-1 MAP kinase in vulval differentiation. (1994)

The let-60 ras gene of Caenorhabditis elegans is one of the key players in a signal transduction pathway that controls the choice between vulval and epidermal differentiation in response to extracellular signals. To identify components acting downstream of let-60 ras in the vulval signaling pathway, we have identified a reduction-of-function mutation in the sur-1 gene that completely suppresses the multivulva phenotype of a hyperactive let-60 ras mutation. About 10% of animals homozygous for the sur-1 mutation also display a specific and intriguing vulval cell lineage defect. In addition, the sur-1 mutation results in a cold-sensitive egg-laying defective phenotype and a partial larval lethal phenotype. We have cloned the sur-1 gene by DNA-mediated transformation and have shown that it encodes a protein similar in overall structure to mammalian MAP kinases (ERKs). The functional homology between Sur-1 MAP kinase and mammalian MAP kinases was also demonstrated by the ability of a rat ERK2 kinase to rescue the sur-1 mutant phenotypes. Genetic double-mutant analyses place sur-1 downstream of let-60 ras but upstream of lin-1 in the vulval signaling pathway. Our results provide further evidence for the extreme conservation of Ras-mediated signaling pathway between worms and humans and for the function of MAP kinases in cell signaling processes that control cell differentiation and animal development.
T lymphocyte activation in systemic lupus erythematosus analysed by proliferative response to nucleoplasmic proteins on nitrocellulose immunoblots. (1989)

Polyclonal B cell activity in systemic lupus erythematosus (SLE) may be under T cell control. The use of nitrocellulose immunoblots for the analysis of recognition by peripheral blood lymphocytes of nucleoplasmic proteins in SLE patients led to the characterization of significant proliferative responses to 68K (U1 RNP); SS-B; B-B' and D (Sm) antigen in 15 of 20 patients. Variations of proliferative response were parallel to disease activity over a follow-up period of greater than or equal to 6 months, conferring some prognostic value to the assay of lymphocyte response to nucleoplasmic antigens. The pattern of reactivity differs from the corresponding serum antibody profile, and purified T cell suspensions (greater than 95% pure) were shown to proliferate in response to soluble nucleoplasmic antigens, indicating that T and B cell repertoires against nucleoplasmic proteins may differ. This suggests that activated helper T cells contribute to the fine modulation of B cell reactivity to subcellular particles to determine the particular antibody profile of the patients.
High speed control scheme of flux reversal machine (2003)

The flux reversal machine (FRM) is a doubly-salient, stator-PM machine. In this paper, the control scheme for the FRM is, for the first time, presented and simulated. Encouraging simulation results are achieved. Two operation modes for the FRM are proposed. The pros and cons of each mode are exemplified and compared. The simulation shows that with proper control, the FRM delivers a good performance.
A Novel Commutation Strategy to Suppress the Common Mode Voltage for the Matrix Converter (2009)

The double line-to-line voltage synthesis of matrix converter is based on the instantaneous value of the input line-to- line voltage. And the obvious advantage of this modulation strategy to automatically suppress the imbalance of the input voltage makes it excellent in the modulation strategy of the matrix converter. Considering the EMI issue in driver system based on matrix converter, common mode voltage is of great importance. Reducing the common voltage actively could be achieved by designing the proper modulation strategy a new modulation strategy with reduced common voltage in the context of double line-to-line voltage synthesis is proposed in this paper. It is based on the idea without employing zero vectors instead of the vectors which are opposite to the active vectors in space vector modulation. The modulation strategy is verified by the simulations finally.
Rapid Detection of Campylobacter coli , C. jejuni , and Salmonella enterica on Poultry Carcasses by Using PCR-Enzyme-Linked Immunosorbent Assay (2003)

Contamination of retail poultry by Campylobacter spp. and Salmonella enterica is a significant source of human diarrheal disease. Isolation and identification of these microorganisms require a series of biochemical and serological tests. In this study, Campylobacter ceuE and Salmonella invA genes were used to design probes in PCR-enzyme-linked immunosorbent assay (ELISA), as an alternative to conventional bacteriological methodology, for the rapid detection of Campylobacter jejuni, Campylobacter coli, and S. enterica from poultry samples. With PCR-ELISA (40 cycles), the detection limits for Salmonella and Campylobacter were 2 x 10(2) and 4 x 10(1) CFU/ml, respectively. ELISA increased the sensitivity of the conventional PCR method by 100- to 1,000-fold. DNA was extracted from carcass rinses and tetrathionate enrichments and used in PCR-ELISA for the detection of Campylobacter and S. enterica, respectively. With PCR-ELISA, Salmonella was detected in 20 of 120 (17%) chicken carcass rinses examined, without the inclusion of an enrichment step. Significant correlation was observed between PCR-ELISA and cultural methods (kappa = 0.83; chi-square test, P < 0.001) with only one false negative (1.67%) and four false positives (6.67%) when PCR-ELISA was used to screen 60 tetrathionate enrichment cultures for Salmonella. With PCR-ELISA, we observed a positive correlation between the ELISA absorbance (optical density at 405 nm) and the campylobacter cell number in carcass rinse, as determined by standard culture methods. Overall, PCR-ELISA is a rapid and cost-effective approach for the detection and enumeration of Salmonella and Campylobacter bacteria on poultry.
[Effect on human complement of blastolysin and the glycopeptide (MDP and GMDP) and carbohydrate fragments of peptidoglycans]. (1985)

Along with complement activation by the classical pathway, blastolysin, an antitumor and adjuvant preparation of Lactobacillus bulgaricus peptidoglycans, effectively inhibits the transformation of C3 in to C5 convertase. Values of inhibition maximum and dissociation constants of the reversible C3b-acceptor complex for blastolysin and main immunological active structural moieties of peptidoglycans (GMDP, MDP) and their inactive carbohydrate components (N-acetylglucosaminyl-N-acetylmuramic acid, N-acetylglucosamine, and N-acetylmuramic acid) have been determined. Immunostimulator concentrations for blastolysin, GMDP, and MDP in inhibition of the C5 convertase formation (C3b binding) correlate with their doses in vivo (animal blood), displaying antitumor activity.
Active neutral point clamped converter for equal loss distribution (2014)

Active neutral point is the most attractive inverter topology in many applications such as a photovoltaic system because of the equal loss distribution among switches. This study presents a new single‐phase five‐level active neutral‐point clamped converter topology. It can be applied to achieve optimal total harmonic distortion. In addition, this topology helps to obtain voltage balancing among the capacitors. An analysis of the switching state and commutation of the converter are also presented here in order to balance the power losses among the semiconductor devices. The simulation has been carried out in MATLAB SIMULINK to investigate the effectiveness of the proposed topology. Experimental results are presented to validate the proposed topology. Moreover, a comparative study has been made to show the cost‐effectiveness of the proposed topology.