gebhart/patrepeval huggingface dataset:
Comparative Study of Complexes of Rare Earths and Actinides with 2,6-Bis(1,2,4-triazin-3-yl)pyridine (2019)

Complexes of group III metals (rare earth and actinides) with 2,6-bis(5,6-dipropyl-1,2,4-triazin-3-yl)pyridine (BTP) have been investigated by computational (DFT) and, in limited cases, by experimental (FT-IR, X-ray) techniques with the goal of determining the characteristics of metal–ligand interactions. The DFT calculations using the M062X exchange-correlation functional revealed that metal–ligand distances correlate with the ionic radii of the metals, in agreement with available X-ray diffraction results on the Sc, Y, La, U, and Pu complexes. A related blue-shift trend could be observed in seven characteristic bands in the IR spectra associated with metal–ligand vibrations. The computations uncovered considerable charge transfer interactions, particularly in the actinide complexes, as important covalent contributions to the metal–ligand bonding. The covalent character of the metal–ligand bonds decreases in the actinides, from U to Cm.
Fetal-Tissue Transplants in Parkinson's Disease (1992)

For five years there has been widespread interest in the possible benefits of implantation of tissue into the brains of patients with Parkinson's disease, starting with reports of success with autologous adrenal medulla tissue1 and fetal ventral mesencephalic (dopaminergic) tissue.2 Claims of dramatic benefit with adrenal medullary implants led to many unsuccessful attempts to replicate the findings, and that approach has been virtually abandoned. Cautious optimism concerning future success with fetal-tissue implantation persisted because there is logic in the idea of dopamine-replacement therapy, and fetal dopaminergic cells could be the source. This approach has been effective in treating the parkinsonian . . .
A randomized controlled trial testing the effectiveness of a paramedic-delivered care transitions intervention to reduce emergency department revisits (2018)

ClinicalTrials.gov Registration: NCT02520661 . Trial registration date: August 13, 2015.
The atom (1952)

One can always tell which part of physics is advancing most rapidly by consulting a few numbers of The Physical Review. Judged by this criterion, the heroic period of the physics of the atom may be taken to be roughly the two decades from 1915 to 1935. (Such dates are never exact.) Prior to 1915 there had been much speculation about the electrical nature of the atom, and Rutherford's work on alpha particle scattering and Bohr's first work on a quantum theory of the atom came a little before 1915. By 1915, however, physicists had really caught the scent of an exciting new forward surge of discovery and were preparing to exploit it fully.
The establishment and application of traffic domain ontology based on data element (2014)

Since the research of transportation ontology and the establishment of traffic data element has been separated from each other, which has caused large workload on ontology establishment and inadequate continuity of the application of standers. To solve these problems, we put forward a method to establish the ontology about traffic information. In this paper, we analyzed the similarity of logical structure relationships between ontology and traffic information data element, the corresponding relationships of constituent elements and the similarity of these relationships firstly, demonstrated the feasibility of interconversion between data element and ontology. Secondly, we reconstruct the data element standard based on object-oriented methods, on this basis, we elaborate how to build a transportation ontology.
Palladium‐Catalyzed Arylation and Heteroarylation of Azolopyrimidines. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Iridium(III) complexes with 1-phenylisoquinoline-4-carbonitrile units for efficient NIR organic light-emitting diodes (2021)

Achieving the high external quantum efficiency (EQE) of near-infrared (NIR) emission in iridium(III) complexes still remains a challenge owing to their unsteady excited states which easily decay to the ground states through the nonradiative pathways. Herein, three Ir(III) phosphors in which the cyclometalated ligand 1-phenylisoquinoline-4-carbonitrile (piq-CN) is functionalized with the cyano, <i>tert-</i>butyl, and dimethyl groups are developed (CN-CNIr, Bu-CNIr, and DM-CNIr, respectively). Three simple synthetic steps can afford this class of deep red to NIR Ir(III) emitters. The organic light-emitting diodes (OLEDs) based on Bu-CNIr and DM-CNIr attain the maximum EQEs of 7.1% and 7.2% with the emission peaks at 695 and 714 nm, respectively. This strategy using substituted piq-CN derivatives as the cyclometalated ligands can offer an effective approach to promote the radiative rate of NIR-emitting Ir(III) materials. An insight into how the electron-withdrawing and electron-donating substituents on ligands influence the optoelectronic properties of their Ir(III) complexes is also provided.
EFFECT OF OXYGENATED PERFLUOROCARBONS ON PANCREATIC ISLETS IN LONG-TERM CULTURE (2004)

A145 Aims: Perfluorocarbons are known for their high oxygen-solubility coefficients and for their maintenance of high-oxygen partial pressures for extended time. They serve also as oxygen “reservoirs” for harvested organs in pancreas organ transplantation. The aim of our study was to assess the influence of oxygen saturated perfluorohexane (PFH) on isolated pancreatic islets at different culture times. Methods: The islets were isolated by collagenase digestion. After purification by density gradient centrifugation and pooling they were divided in aliquots in Petri dishes and cultured with RPMI-1640 medium with or without oxygen saturated PFH at 37°C. During cultivation medium change and oxygen saturation was performed every second day. For assessment of islet function we measured insulin secretion by RIA. Secretory granules were examined by immunoelectronmicroscopy, while the levels of polypyrimidine tract-binding protein (PTB), a factor promoting secretory granule biogenesis, were measured by western blotting. Apoptosis was assessed by PARP-immunostaining, necrosis with trypan blue-staining, and expression of insulin and ICA512 (markers of secretory granules) mRNAs by quantitative real-time PCR. Results: After 1 and 7 days in culture insulin secretion was significantly decreased in PFH treated islets. We also detected a tendency to a higher rate of apoptosis and necrosis, a reduced expression of PTB and of insulin and ICA512 mRNAs compared to islets grown for the same length of time in the absence of PFH. Conclusions: PFH has a detrimental effect on the viability of purified rat islets. Our data show that PFH, while advantageous for the transport of harvested organs, is not indicated during the purification and culture of islets for transplantation.
Vibrotactile Funneling Illusion and Localization Performance on the Head (2020)

The vibrotactile funneling illusion is the sensation of a single (non-existing) stimulus somewhere in-between the actual stimulus locations. Its occurrence depends upon body location, distance between the actuators, signal synchronization, and intensity. Related work has shown that the funneling illusion may occur on the forehead. We were able to reproduce these findings and explored five further regions to get a more complete picture of the occurrence of the funneling illusion on the head. The results of our study (24 participants) show that the actuator distance, for which the funneling illusion occurs, strongly depends upon the head region. Moreover, we evaluated the centralizing bias (smaller perceived than actual actuator distances) for different head regions, which also showed widely varying characteristics. We computed a detailed heat map of vibrotactile localization accuracies on the head. The results inform the design of future tactile head-mounted displays that aim to support the funneling illusion.
Contours extraction in grayscale images of sign language interpreter (2008)

This work presents one new approach for adaptive extraction of the contours of the sign language interpreter in video sequences. The aim of the processing is to obtain clear contour images, which retain the understandability of the interpreted signs and together with this, ensure very efficient compression of the processed video sequences. In the paper is presented the algorithm used in the consecutive stages of the image processing illustrated with some experimental results. The algorithm is based on two-stage filtration (noise filtration with local adaptive digital filtration, followed by uneven illumination correction with 2D linear digital filtration). The processing then continues with image segmentation. The presented approach is of great importance for video sign-language presentations, because in result of the usually used inter-frame compression their understandability is not so good, if they comprise quick movements of interpreter's hands. In order to avoid this, the new approach is based on the assumption that the color video sequences are substituted with similar ones, which contain the extracted contours only. The understandability of the represented signs is retained, because in this case instead of inter-frame lossy compression, is used intra-frame lossless compression. The obtained compression ratio is very high, which permits real-time implementations of the presented approach.
Energy-trapped shallow bulk acoustic waves (1979)

A low-loss high-sidelobe-rejection shallow bulk acoustic filter has been constructed. The delay line consisted of apodised and finger-withdrawal-weighted transducers as well as a metallic energy-trapping grating. Experimental results are given and discussed.
Optical Recording at 2.4 Gbit/in2 Using a Frequency Doubled Diode Laser (1993)

Optical recording at 2.4 Gbit/in 2 has been demonstrated at both 488 nm (argon-ion laser) and at 429 nm (doubled diode laser) using TbFeCo and CoPt multilayers on flat glass media with a soft sampled servo tracking system. The data was written using pulse width modulation (PWM), 2/3 (1, 7) run length limited (RLL) encoding, and detection accomplished using a dual clock channel. Edge shifts of 3.5% of the timing window and jitters of 7% of the timing window were observed. At a data rate of 2 MBytes/s and with data written on adjacent tracks, a bit error rate of 10 -5 with noise margins of 10 dB and 8.5 dB were measured at 488 nm and 429 nm, respectively.
Obesity, Type 2 Diabetes and Bone in Adults (2017)

In an increasingly obese and ageing population, type 2 diabetes (T2DM) and osteoporotic fracture are major public health concerns. Understanding how obesity and type 2 diabetes modulate fracture risk is important to identify and treat people at risk of fracture. Additionally, the study of the mechanisms of action of obesity and T2DM on bone has already offered insights that may be applicable to osteoporosis in the general population. Most available evidence indicates lower risk of proximal femur and vertebral fracture in obese adults. However the risk of some fractures (proximal humerus, femur and ankle) is higher, and a significant number fractures occur in obese people. BMI is positively associated with BMD and the mechanisms of this association in vivo may include increased loading, adipokines such as leptin, and higher aromatase activity. However, some fat depots could have negative effects on bone; cytokines from visceral fat are pro-resorptive and high intramuscular fat content is associated with poorer muscle function, attenuating loading effects and increasing falls risk. T2DM is also associated with higher bone mineral density (BMD), but increased overall and hip fracture risk. There are some similarities between bone in obesity and T2DM, but T2DM seems to have additional harmful effects and emerging evidence suggests that glycation of collagen may be an important factor. Higher BMD but higher fracture risk presents challenges in fracture prediction in obesity and T2DM. Dual energy X-ray absorptiometry underestimates risk, standard clinical risk factors may not capture all relevant information, and risk is under-recognised by clinicians. However, the limited available evidence suggests that osteoporosis treatment does reduce fracture risk in obesity and T2DM with generally similar efficacy to other patients.
Heterodimerization of theEntamoeba histolyticaEhCPADH virulence complex through molecular dynamics and protein–protein docking (2016)

EhCPADH is a protein complex involved in the virulence of Entamoeba histolytica, the protozoan responsible for human amebiasis. It is formed by the EhCP112 cysteine protease and the EhADH adhesin. To explore the molecular basis of the complex formation, three-dimensional models were built for both proteins and molecular dynamics simulations (MDS) and docking calculations were performed. Results predicted that the pEhCP112 proenzyme and the mEhCP112 mature enzyme were globular and peripheral membrane proteins. Interestingly, in pEhCP112, the propeptide appeared hiding the catalytic site (C167, H329, N348); while in mEhCP112, this site was exposed and its residues were found structurally closer than in pEhCP112. EhADH emerged as an extended peripheral membrane protein with high fluctuation in Bro1 and V shape domains. 500 ns-long MDS and protein-protein docking predictions evidenced different heterodimeric complexes with the lowest free energy. pEhCP112 interacted with EhADH by the propeptide and C-terminal regions and mEhCP112 by the C-terminal through hydrogen bonds. In contrast, EhADH bound to mEhCP112 by 442-479 residues, adjacent to the target cell-adherence region (480-600 residues), and by the Bro1 domain (9-349 residues). Calculations of the effective binding free energy and per residue free energy decomposition showed that EhADH binds to mEhCP112 with a higher binding energy than to pEhCP112, mainly through van der Waals interactions and the nonpolar part of solvation energy. The EhADH and EhCP112 structural relationship was validated in trophozoites by immunofluorescence, TEM, and immunoprecipitation assays. Experimental findings fair agreed with in silico results.
NMR studies of cobalt(II)-substituted derivatives of bovine copper-zinc superoxide dismutase. Effects of pH, phosphate, and metal migration (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNMR studies of cobalt(II)-substituted derivatives of bovine copper-zinc superoxide dismutase. Effects of pH, phosphate, and metal migrationLi June Ming and Joan Selverstone ValentineCite this: J. Am. Chem. Soc. 1990, 112, 11, 4256–4264Publication Date (Print):May 1, 1990Publication History Published online1 May 2002Published inissue 1 May 1990https://pubs.acs.org/doi/10.1021/ja00167a021https://doi.org/10.1021/ja00167a021research-articleACS PublicationsRequest reuse permissionsArticle Views104Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Understanding and characterizing flake polymorphisms as a quality attribute for microwave popcorn (2012)

This work provides a new and easy method to combine cyclodextrins and carbon dots into a biocompatible material which can be used as nanoplatform both as drug delivery system and as photoluminescent tag in cell imaging. Likewise, this paper shows how to characterize the number of cyclodextrins and active cyclodextrins per CD, having an average stoichiometric relation of 1:1 for guest molecule - CD. Additionally, the minimum molecular mass of the unmodified CD was indirectly obtained, yielding about 1.6-1.9 kDa.
Far‐field harmonic measurement for seismic vibrators (1996)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1996Far‐field harmonic measurement for seismic vibratorsAuthors: B. P. JeffryesB. P. JeffryesSchlumberger Cambridge Researchhttps://doi.org/10.1190/1.1826718 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1826718FiguresReferencesRelatedDetailsCited byPhysical Experiments and Stochastic Modeling to Clarify the System Containing the Seismic Source and the GroundBreak through the limits of vibroseis data quality31 August 2011 | Geophysical Prospecting, Vol. 60, No. 2Fundamental discussions on seismic vibratorsZhouhong Wei, Thomas F. Phillips, and Michael A. Hall18 November 2010 | GEOPHYSICS, Vol. 75, No. 6Acquisition and processing of simultaneous vibroseis dataGeophysical Prospecting, Vol. 58, No. 1Extending the seismic bandwidth — A simultaneous uncorrelated VSP and surface seismic field test studyPeter I. Pecholcs, Riyadh Al‐Saad, Huibert B. Heijna, Jakob B. U. Haldorsen, Richard T. Coates, César Barajas‐Olalde, and Shabbir Ahmed15 December 2008Model parameters of the nonlinear stiffness of the vibrator-ground contact determined by inversion of vibrator accelerometer dataAndrey V. Lebedev, Igor A. Beresnev, and Pieter L. Vermeer24 May 2006 | GEOPHYSICS, Vol. 71, No. 3Nonlinear distortion of signals radiated by vibroseis sourcesAndrey V. Lebedev and Igor A. Beresnev28 July 2004 | GEOPHYSICS, Vol. 69, No. 4 SEG Technical Program Expanded Abstracts 1996ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1996 Pages: 2106 publication data© 1996 Copyright © 1996 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 10 Feb 2005 CITATION INFORMATION B. P. Jeffryes, (1996), "Far‐field harmonic measurement for seismic vibrators," SEG Technical Program Expanded Abstracts : 60-63. https://doi.org/10.1190/1.1826718 Plain-Language Summary PDF DownloadLoading ...
Induction of Xenogeneic Neonatal Tolerance to Transgenic Human Leukocyte Antigen Class I Grafts (2004)

These experiments demonstrate that, as long as species-specific molecular interactions are maintained, recognition of the polymorphic domains of xenogeneic MHC does not represent a barrier to neonatal tolerance induction.
Radiation therapy for pituitary metastasis: report of four cases. (2012)

Treatment with three-dimensional conformal radiotherapy or stereotactic radiotherapy is a suitable non-surgical option for patients with pituitary metastases.
Weakly Supervised Deep Detection Networks (2016)

Weakly supervised learning of object detection is an important problem in image understanding that still does not have a satisfactory solution. In this paper, we address this problem by exploiting the power of deep convolutional neural networks pre-trained on large-scale image-level classification tasks. We propose a weakly supervised deep detection architecture that modifies one such network to operate at the level of image regions, performing simultaneously region selection and classification. Trained as an image classifier, the architecture implicitly learns object detectors that are better than alternative weakly supervised detection systems on the PASCAL VOC data. The model, which is a simple and elegant end-to-end architecture, outperforms standard data augmentation and fine-tuning techniques for the task of image-level classification as well.
Studies on the syntheses of heterocyclic compounds. Part CXXXV. The structure of corpaverine (1966)

Synthetic 1,2,3,4-tetrahydro-8-hydroxy-6,7-dimethoxy-1-(4-methoxybenzyl)-2-methylisoquinoline has been shown to differ from natural corpaverine. Separation of the natural product by recrystallisation and thin-layer chromatography has shown it to be a mixture of, or a molecular compound of, capaurine and sendaverine.
Correlates of response and outcomes with talimogene laherperpvec (2019)

These findings demonstrate that TVEC is an effective and safe treatment for metastatic melanoma in a real-life clinical setting, and suggest parameters to aid in appropriate therapy selection for optimal response.
The Influence of the Spatio-Temporal Terzi Treatment on the Kinematics of Cursive Writing of Dysgraphic Subjects (2017)

Many different treatment approaches have been applied for handwriting remediation in school-aged children. The effects of these treatments are usually evaluated by using ad-hoc checklists as well as some standard test protocols like Movement ABC tests, Visual-Motor Integration (V.M.I.) tests, etc. Recently, digitizing tablets have allowed the study of kinematic characteristics of handwriting and a series of parameters were estimated on cursive writing of Italian children. In this paper, the influence of a new rehabilitation protocol (Terzi's method) on kinematics of cursive writing was evaluated. The analysis was carried out on 22 nonproficient handwriting children, attending primary or secondary school, which undertook a series of three exercises, with and without linguistic concerns. A set of kinematic parameters was calculated before and after the rehabilitation process. The results showed that Terzi's rehabilitation program is capable of producing a significant velocity increase in the test without linguistic involvement, whereas a significant slowdown in the stroke realization was present in the other tasks. The effectiveness of Terzi's rehabilitation program was proved by significant improvements in the V.M.I. test, in the Movement ABC test as well as in writing legibility (evaluated by checklist).
Irrigation water measurement (1993)

Danny H. Rogers &amp; Richard D. Black, Irrigation water measurement, Kansas State University, June 1993.
U.S. Food and Drug Administration Approval: Obinutuzumab in Combination with Chlorambucil for the Treatment of Previously Untreated Chronic Lymphocytic Leukemia (2014)

On November 1, 2013, the U.S. Food and Drug Administration (FDA) approved obinutuzumab (GAZYVA; Genentech, Inc.), a CD20-directed cytolytic antibody, for use in combination with chlorambucil for the treatment of patients with previously untreated chronic lymphocytic leukemia (CLL). In stage 1 of the trial supporting approval, patients with previously untreated CD20-positive CLL were randomly allocated (2:2:1) to obinutuzumab + chlorambucil (GClb, n = 238), rituximab + chlorambucil (RClb, n = 233), or chlorambucil alone (Clb, n = 118). The primary endpoint was progression-free survival (PFS), and secondary endpoints included overall response rate (ORR). Only the comparison of GClb to Clb was relevant to this approval and is described herein. A clinically meaningful and statistically significant improvement in PFS with medians of 23.0 and 11.1 months was observed in the GClb and Clb arms, respectively (HR, 0.16; 95% CI, 0.11-0.24; P < 0.0001, log-rank test). The ORRs were 75.9% and 32.1% in the GClb and Clb arms, respectively, and the complete response rates were 27.8% and 0.9% in the GClb and Clb arms, respectively. The most common adverse reactions (≥10%) reported in the GClb arm were infusion reactions, neutropenia, thrombocytopenia, anemia, pyrexia, cough, and musculoskeletal disorders. Obinutuzumab was the first Breakthrough Therapy-designated drug to receive FDA approval.