gebhart/patrepeval huggingface dataset:
A Small Molecule Inhibitor of Human RAD51 Potentiates Breast Cancer Cell Killing by Therapeutic Agents in Mouse Xenografts (2014)

The homologous recombination pathway is responsible for the repair of DNA double strand breaks. RAD51, a key homologous recombination protein, promotes the search for homology and DNA strand exchange between homologous DNA molecules. RAD51 is overexpressed in a variety of cancer cells. Downregulation of RAD51 by siRNA increases radio- or chemo-sensitivity of cancer cells. We recently developed a specific RAD51 small molecule inhibitor, B02, which inhibits DNA strand exchange activity of RAD51 in vitro. In this study, we used human breast cancer cells MDA-MB-231 to investigate the ability of B02 to inhibit RAD51 and to potentiate an anti-cancer effect of chemotherapeutic agents including doxorubicin, etoposide, topotecan, and cisplatin. We found that the combination of B02 with cisplatin has the strongest killing effect on the cancer cells. We then tested the effect of B02 and cisplatin on the MDA-MB-231 cell proliferation in mouse xenografts. Our results showed that B02 significantly enhances the therapeutic effect of cisplatin on tumor cells in vivo. Our current data demonstrate that use of RAD51-specific small molecule inhibitor represents a feasible strategy of a combination anti-cancer therapy.
New Antihypertensive Aminoalkyltetrazoles (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew Antihypertensive AminoalkyltetrazolesShin. Hayao, Herbert J. Havera, Wallace G. Strycker, T. J. Leipzig, and Rodolfo. RodriguezCite this: J. Med. Chem. 1967, 10, 3, 400–402Publication Date (Print):May 1, 1967Publication History Published online1 May 2002Published inissue 1 May 1967https://pubs.acs.org/doi/10.1021/jm00315a025https://doi.org/10.1021/jm00315a025research-articleACS PublicationsRequest reuse permissionsArticle Views101Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Inheritance and linkage of resistance in cucumber line SMR-18 to races 1 and 2 of Fusarium oxysporum f.sp. cucumerinum (1995)

Studies were carried out on the inheritance of resistance to race 2, and the linkage relationship between resistance to races 1 and 2 of Fusarium oxysporum f.sp. cucumerinum in the cucumber cv. SMR-18, as well as on the reactions of several cucumber cultivars to inoculations with race 2. The inbred line Straight-8 (P 1 (susceptible to races 1 and 2 of F. oxysporum f.sp. cucumerinum) was crossed with the inbred line SMR-18 (P 2 ) (resistant to both races). When F 1 , F 2 , BC 1 P 2 and BC 1 P 2 progenies were inoculated at the cotyledon stage with a suspension of spores of F. oxysporum f.sp. cucumerinum race 2, the ratios of resistant to susceptible plants indicated that resistance was conferred by a single dominant locus. When 158 BC 1 P 1 plants were selfed, and from each resulting F 2 family different groups of 12-18 seedlings each were tested for resistance to either race 1 or race 2, segregation data indicated a complete linkage between the two loci conferring resistance to these by inoculation with F. oxysporum f.sp. cucumerinum race 2, races. Among the 34 cultivars tested at the seedling stage, five were susceptible, while the remainder were highly resistant
Reversing Polarity: Carbonyl α‐Aminations with Nitrogen Nucleophiles (2017)

The synthesis of α-amino carbonyl compounds is an important challenge in synthesis en route to biologically essential structures. While classical approaches involve the use of enol or enolate chemistries in combination with an electrophilic source of nitrogen, those strategies usually necessitate further transformations to reach the desired targets. In recent years, a new approach arose involving the direct use of nucleophilic sources of nitrogen along with an oxidant. This approach advantageously leads, in one-pot, to the biologically relevant α-amino compound without requiring further transformation. This review highlights the recent advances in the emerging field of oxidative α-amination reactions using nucleophilic sources of nitrogen.
Protein transport: A selective membrane mechanism (1976)

Proteins are selectively sequestered by a number of cell types. However, only in oocytes is the process sufficiently aggravated and specific to be readily studied. In these cells certain serum proteins are taken up in proportions different from those found in the serum. In vitro incubations of hormonally stimulated and synchronous mosquito oocytes show that the only protein capable of initiating the transport process is the female specific yolk protein. Heterologous proteins such as IgG, bovine serum albumin, cytochrome C, and ferritin are inactive. The female specific protein is a phosphoglycolipoprotein. It is synthesized in the fat body, a liver analog in the insect, and passed into the serum before being transported into the oocytes. Preliminary kinetic analysis shows the uptake process to be specific with an apparent Km of about 10(-7) M. Glycolytic inhibitors stop protein uptake. The receptor-mediated binding steps in the transport process are most easily studied in the chicken because of the enormous amount of oocyte membrane available from a given oocyte and because up to 1 gm of protein is normally transported per day per oocyte. IgG and the hen specific phosvitin lipovitellin are two of the physiologically important proteins that are transported intact into the chicken oocytes. The uptake appears selective as shown by studies with iodinated proteins. Ferritin conjugated to IgG is shown by electron microscopy to bind to isolated plasma membranes only where coated pits have formed, whereas ferritin alone is not seen localized on any membrane surface. These very specialized regions of the membrane are similar to micropinocytotic pits but, in addition, possess on their cytoplasmic side dense ridges that form the coat. Transport involves binding to the coated pits, the pinching off of the pits, and the subsequent movement of the coated vesicles in the cytoplasm.
Hall plateaus at magic angles in bismuth beyond the quantum limit (2009)

We present a study of the angular dependence of the resistivity tensor up to 35 T in elemental bismuth complemented by torque magnetometry measurements in a similar configuration. For at least two particular field orientations a few degrees off the trigonal axis, the Hall resistivity was found to become field independent within experimental resolution in a finite field window corresponding to a field which is roughly three times the frequency of quantum oscillations. The Hall plateaus rapidly vanish as the field is tilted off these magic angles. We identify two distinct particularities of these specific orientations, which may play a role in the emergence of the Hall plateaus.
Investigation of the Amycolatopsis sp. Strain ATCC 39116 Vanillin Dehydrogenase and Its Impact on the Biotechnical Production of Vanillin (2012)

The actinomycete Amycolatopsis sp. strain ATCC 39116 is capable of synthesizing large amounts of vanillin from ferulic acid, which is a natural cell wall component of higher plants. The desired intermediate vanillin is subject to undesired catabolism caused by the metabolic activity of a hitherto unknown vanillin dehydrogenase (VDH(ATCC 39116)). In order to prevent the oxidation of vanillin to vanillic acid and thereby to obtain higher yields and concentrations of vanillin, the responsible vanillin dehydrogenase in Amycolatopsis sp. ATCC 39116 was investigated for the first time by using data from our genome sequence analysis and further bioinformatic approaches. The vdh gene was heterologously expressed in Escherichia coli, and the encoded vanillin dehydrogenase was characterized in detail. VDH(ATCC 39116) was purified to apparent electrophoretic homogeneity and exhibited NAD(+)-dependent activity toward vanillin, coniferylaldehyde, cinnamaldehyde, and benzaldehyde. The enzyme showed its highest level of activity toward vanillin at pH 8.0 and at a temperature of 44°C. In a next step, a precise vdh deletion mutant of Amycolatopsis sp. ATCC 39116 was generated. The mutant lost its ability to grow on vanillin and did not show vanillin dehydrogenase activity. A 2.3-times-higher vanillin concentration and a substantially reduced amount of vanillic acid occurred with the Amycolatopsis sp. ATCC 39116 Δvdh::Km(r) mutant when ferulic acid was provided for biotransformation in a cultivation experiment on a 2-liter-bioreactor scale. Based on these results and taking further metabolic engineering into account, the Amycolatopsis sp. ATCC 39116 Δvdh::Km(r) mutant represents an optimized and industrially applicable platform for the biotechnological production of natural vanillin.
Continuing Medical Education Questions: May 2009 (2009)

QUESTIONS: 1. W hich of the following are consensus statements on the de nition of GERD in the pediatric population? A. GERD is p resent when re˚ ux of gastric contents causes troublesome symptoms and/or complications. B . S ymptoms due to GERD are troublesome when they have an adverse e ect on the well-being of the pediatric patient. C . S ymptoms of GERD vary by age. D. All of the above. 2. On the basis of the consensus de nition of GERD in the pediatric population, regurgitation is considered to be a characteristic symptom of re ux in infants, but is neither necessary nor su cient for diagnosing GERD. A. True B. False 3. On the basis of the consensus de nition of GERD, which of the following conditions are considered to predispose children to the most severe and chronic GERD? A . C entral nervous system impairment B. Esophageal atresia C. Cystic brosis D. All of the above
Domain Controlled Architecture - A New Approach for Large Scale Software Integrated Automotive Systems (2013)

Electric and electronic functionalities increase exponentially in every mobility domain. The automotive industry is confronted with a rising system complexity and several restricting requirements and standards (like AUTOSAR), in particular to design embedded software for electronic control units. To stand against rampant functionalities software units could be restructured according to their affiliation and should not be attached to a certain place. This can be effected by integration on single controllers. On the one hand the system wide amount of hardware controllers could such be limited. On the other hand the workload for integration CPUs will rise. To support this paradigm, multi-core systems can provide enough processing power in an efficient way. This paper shows a first approach to combine automotive functionality on such a single controller.
The N.A.I.C.C. Project: A Navigation Aided Intelligent Cruise Control System (2000)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;Developing a knowledge-based predictive driver-aid system requires a strategy that meets the needs and goals, as well as rigorous methods. This paper presents the strategy adopted and the first results obtained in the development of the Navigation Aided Intelligent Cruise Control (N.A.I.C.C.) system. Once the vehicle is located on the route, this new copilot can: &lt;ol class="list nostyle"&gt; &lt;li class="list-item"&gt; &lt;span class="li-label"&gt;1.&lt;/span&gt; &lt;div class="htmlview paragraph"&gt;define the travel direction and the vehicle speed,&lt;/div&gt;&lt;/li&gt; &lt;li class="list-item"&gt; &lt;span class="li-label"&gt;2.&lt;/span&gt; &lt;div class="htmlview paragraph"&gt;determine the distance to the next bend and its characteristics,&lt;/div&gt;&lt;/li&gt; &lt;li class="list-item"&gt; &lt;span class="li-label"&gt;3.&lt;/span&gt; &lt;div class="htmlview paragraph"&gt;predict the optimal speed to negotiate the next bend considering the road profile, the constraints given by the driver and the information provided by the sensors mounted on the vehicle.&lt;/div&gt;&lt;/li&gt;&lt;/ol&gt;&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;Then, used in the warning mode (“Driver Alarm Mode”), N.A.I.C.C. informs the driver of the danger of the situation (excessive speed) or, in the intervention mode (“Velocity Control Mode”), N.A.I.C.C. adapts the speed to the predicted reference. In this latter operating mode, N.A.I.C.C. can be considered as an advanced intelligent cruise control system. Real experiments were carried out with the laboratory test car to validate each module described.&lt;/div&gt;&lt;/div&gt;
Auto-clustering Output Layer: Automatic Learning of Latent Annotations\n in Neural Networks (2017)

In this paper, we discuss a different type of semi-supervised setting: a\ncoarse level of labeling is available for all observations but the model has to\nlearn a fine level of latent annotation for each one of them. Problems in this\nsetting are likely to be encountered in many domains such as text\ncategorization, protein function prediction, image classification as well as in\nexploratory scientific studies such as medical and genomics research. We\nconsider this setting as simultaneously performed supervised classification\n(per the available coarse labels) and unsupervised clustering (within each one\nof the coarse labels) and propose a novel output layer modification called\nauto-clustering output layer (ACOL) that allows concurrent classification and\nclustering based on Graph-based Activity Regularization (GAR) technique. As the\nproposed output layer modification duplicates the softmax nodes at the output\nlayer for each class, GAR allows for competitive learning between these\nduplicates on a traditional error-correction learning framework to ultimately\nenable a neural network to learn the latent annotations in this partially\nsupervised setup. We demonstrate how the coarse label supervision impacts\nperformance and helps propagate useful clustering information between\nsub-classes. Comparative tests on three of the most popular image datasets\nMNIST, SVHN and CIFAR-100 rigorously demonstrate the effectiveness and\ncompetitiveness of the proposed approach.\n
Traffic grooming in WDM networks (2001)

The emergence of wavelength-division multiplexing technology has led to a tremendous increase In the available transmission capacity in wide area networks. Consequently, these networks may no longer be limited by the transmission bandwidth, but rather by the processing capability of electronic switches, routers, and multiplexers in the network. This realization has led to a new wave of research aimed at overcoming the electronic bottleneck by providing optical bypass at the WDM layer. Traffic grooming can be used as a bypass mechanism by which low-rate circuits are assigned to wavelengths in order to minimize the amount of electronic multiplexing equipment. This topic has received a significant amount of attention in both the research and commercial arenas. We give an overview of the traffic grooming problem and survey some representative work in this area. While most work has focused on grooming in SONET rings, grooming traffic in general mesh networks is an important emerging problem.
Nitration of methyl oleate with acetyl nitrate: A synthesis of methyl aminostearate (1963)

Abstract Acetyl nitrate, an effective reagent for the nitration of simple alkenes, provided a convenient means of introducing nitrogen into unsaturated fatty acids. This nitrating agent was found to react quantitatively under mild conditions with methyl oleate forming isomeric nitro, acetoxy‐nitro, and nitro‐nitrate derivatives. These nitro derivatives were isolated by column and thin‐layer adsorption chromatography, and their structures were elucidated by infrared spectroscopy. In addition, the isomeric nitro derivative was reduced by catalytic hydrogenation to give methyl aminostearate.
EEPROM as an analog storage device, with particular applications in neutral networks (1992)

The use of EEPROM as a compact, high-precision, nonvolatile, and reconfigurable analog storage element is investigated, with particular consideration given to the modifiable weight storage and analog multiplication problems in the hardware implementation of a neural network. Industry-standard digital EEPROM cells can be programmed to any analog value of threshold voltage, but programming characteristics of different devices on the same chip vary. The programming window of a single device also narrows with cycling. These phenomena necessitate the use of a feedback-based programming scheme. Stressing at high temperature suggests that charge retention is good even at 175 degrees C. The linear variation of threshold voltage with temperature implies that temperature compensation of EEPROM is no more complicated than its conventional MOSFET counterpart. The drain current in the saturation region is found to be a quadratic function of drain voltage when the floating-gate-to-drain overlap capacitance is adequately large. A differential circuit that uses this property to generate the multiplication function required of neural net synapses is proposed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Superhydrophobic and superoleophobic conducting polymers with tunable surface nanofibrous structures and nanoporosity (2014)

International audience
Scaffolding Networks: Incremental Learning and Teaching Through Questioning (2017)

We introduce a new paradigm of learning for reasoning, understanding, and prediction, as well as the scaffolding network to implement this paradigm. The scaffolding network embodies an incremental learning approach that is formulated as a teacher-student network architecture to teach machines how to understand text and do reasoning. The key to our computational scaffolding approach is the interactions between the teacher and the student through sequential questioning. The student observes each sentence in the text incrementally, and it uses an attention-based neural net to discover and register the key information in relation to its current memory. Meanwhile, the teacher asks questions about the observed text, and the student network gets rewarded by correctly answering these questions. The entire network is updated continually using reinforcement learning. Our experimental results on synthetic and real datasets show that the scaffolding network not only outperforms state-of-the-art methods but also learns to do reasoning in a scalable way even with little human generated input.
[Aflatoxin contamination level in artisanal and industrial peanut butter food in Dakar (Senegal)]. (2000)

Aflatoxins are mycotoxins produced by some strains of fungus (Aspergillus) which develop in peanut seeds. Peanut oil and past are very used up in Senegal, then the aflatoxin poisoning risk is very actual. The aim of this study was to determinate the aflatoxin level in artisanal and industrial peanut pastry food from Dakar (Sénégal). High Performance Liquid Chromatography (HPLC) analysis of the different samples showed that the most contaminated by aflatoxins are artisanal pastry sold in different market of Dakar (Sénégal). Indeed, 40% of these samples contained mean values of aflatoxin B1 (the most dangerous) widely over allowable EEC specifications (5ppb). Furthermore, most of industrial and domestic peanut pastry were cleaned and could be consumed without risk.
A new method of peak torque reduction with redundant manipulators (1997)

A new method aiming at reducing peak torques is developed in this paper for kinematically redundant manipulators. The method considers the contributions of both velocity and acceleration to the joint torque. Instead of minimizing the joint torque or kinetic energy at the current station, the method always uses the current torque to approach an optimum velocity of the following station, which, along with joint acceleration, minimizes the torque of the following station, while at the same time keeps the current torque within the limits. Simulations are conducted for three cases and the results show the clear superiority of the proposed method over the conventional torque optimization and energy minimization methods.
Analysis of Hemodynamics and Aneurysm Occlusion after Flow-Diverting Treatment in Rabbit Models (2014)

These results suggests that the dominant healing mechanism of occlusion within the aneurysm dome is related to slow-flow-induced thrombosis, while near the neck, other processes could be at play simultaneously.
ChemInform Abstract: Carbon Nucleophile Addition to sp2‐Unsaturated Fischer Carbene Complexes (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Population pharmacokinetics of dolutegravir in HIV‐infected treatment‐naive patients (2015)

A population model that adequately characterizes dolutegravir pharmacokinetics has been developed. No dolutegravir dose adjustment by patient covariates is necessary in HIV-infected treatment-naive patients.
Contrast Sensitivity and Increment Threshold (1972)

The threshold of rectangular and annular increments was established on square-wave gratings of 1 foot lambert mean luminance. In the range of 5–18 cycles/degree the threshold fell as the spatial frequency of the background increased. The threshold change was similar for rectangles and annuli, but the exponent of the curve differed according to the relative orientation of the test stimulus. The threshold curve of rectangles was related to the human contrast sensitivity curve, and it was found that threshold is directly proportional to the contrast of the grating and effective contrast is a function of the spatial frequency of the pattern. In the range below 5 cycles/degree of the grating pattern the threshold dropped. This is attributed to the low-frequency decline in contrast sensitivity, but this decrease occurred at a higher spatial frequency than expected. Apparently orientation and size specificity in field adaptation is compatible with functions of cells established in the visual cortex of primates and humans.
Embedded Digital Information Integrated by Video-on-Demand System (2008)

With the incessant develop in computer technology, and multimedia in recent years has become an increasingly popular service. Video-on-demand (VOD) has been widely used to provide an alternative channel to conventional TV for viewers to receive media programs. We propose VOD based on a combination of printed QR-codes. Since QR-code is able to be read by such as mobile phone with camera, a consumer is able to get list of VOD system with a single scanning operation. We design a VOD system, which apply to heterogeneous wireless IP networks. It lets the system more robust.