gebhart/patrepeval huggingface dataset:
Do Patients with Right Ventricular Outflow Tract Ventricular Arrhythmias Have a Normal Right Ventricular Wall Motion? (2005)

The RV wall motion is nonuniform in contour area change, strain, and timing of motion. Patients with RVOT ventricular ectopy demonstrate wall motion parameters similar to those of normal subjects. This technique should be applicable in analyzing RV wall motion in patients suspected of having ARVC/D.
Cortical somatosensory evoked potentials in response to hand stimulation (1983)

✓ Somatosensory evoked potentials were recorded from chronically implanted subdural electrodes in six patients with intractable seizures. The following conclusions were reached: 1) The initial cortical negativity-positivity (N 1 with a latency of about 20 msec and P 2 with a latency of about 24 msec) recorded in the postcentral area was an expression of the classical primary surface positivity, but N 1 was generated by the posterior pole of an early horizontal dipole in area 3b, and P 2 was generated by the positive pole of a slightly delayed vertical dipole in area 1 and 2. 2) P 2 permitted the most accurate localization of the primary somatosensory area. 3) No potentials were elicited in the primary somatosensory area by stimulation of the ipsilateral hand. 4) No cortical potentials were seen at stimulation intensities below the sensory threshold. The cortical distribution of evoked potentials evoked by weak and strong intensities had significantly different distribution. 5) The recovery function of cortical evoked potentials showed a U-curve with an early period of facilitation (10 to 30 msec) followed by a prolonged period of subnormality which peaked at about 50 msec. The recovery curve at different cortical loci differed.
How to calculate stress in above/below ground transition (1976)

Stresses and deflections occur in natural gas pipe lines at the transition from the below ground (fully restrained) to the above ground (unrestrained) condition. Analysis of the stresses and deflections in transition areas, resulting from internal pressure/temperature change, is necessary in determining anchor block requirements and design. Longitudinal deflections are used to determine whether an anchor block is required. Anchor block forces required to maintain the pipe in a fully constrained condition are then determined. A brief review of the analysis that resulted in more accurate solutions for deflection and anchor block forces is presented. Sample calculations are given for line sizes up to 41-cm OD, pressure to 193 bars, and temperatures to 72/sup 0/C. (JRD)
Practical Range Sensing with Thermal Light (2023)

Many quantum sensing suggestions rely on temporal correlations found in photon pairs generated by parametric down-conversion. In this work, we show that the temporal correlations in light with a thermal photon statistics can be equally useful for such applications. Using a subthreshold laser diode as an ultrabright source of thermal light, we demonstrate optical range finding to a distance of up to 1.8 km.
Gene regulatory network and its constituent transcription factors that control nitrogen‐deficiency responses in rice (2020)

Increase in the nitrogen (N)-use efficiency and optimization of N response in crop species are urgently needed. Although transcription factor-based genetic engineering is a promising approach for achieving these goals, transcription factors that play key roles in the response to N deficiency have not been studied extensively. Here, we performed RNA-seq analysis of root samples of 20 Asian rice (Oryza sativa) accessions with differential nutrient uptake. Data obtained from plants exposed to N-replete and N-deficient conditions were subjected to coexpression analysis and machine learning-based pathway inference to dissect the gene regulatory network required for the response to N deficiency. Four transcription factors, including members of the G2-like and bZIP families, were predicted to function as key regulators of gene transcription within the network in response to N deficiency. Cotransfection assays validated inferred novel regulatory pathways, and further analyses using genome-edited knockout lines suggested that these transcription factors are important for N-deficiency responses in planta. Many of the N deficiency-responsive genes, including those encoding key regulators within the network, were coordinately regulated by transcription factors belonging to different families. Transcription factors identified in this study could be valuable for the modification of N response and metabolism.
A lightweight multifunctional interlayer of sulfur–nitrogen dual-doped graphene for ultrafast, long-life lithium–sulfur batteries (2016)

A lightweight multifunctional SNGE interlayer was developed, which enabled the PCNT–S cathode to deliver a high reversible specific capacity and extraordinarily excellent cycling stability at ultrahigh rates.
Fair Algorithms for Maximal Link Activation in Multihop Radio Networks (1987)

We present a distributed algorithm for obtaining a fair time slot allocation for link activation in a multihop radio network. We introduce the concept of maximal fairness in which the termination of a fair allocation algorithm is related to maximal reuse of the channel under a given fairness metric. The fairness metric can be freely interpreted as the expected link traffic load demands, link priorities, etc. Since respective demands for time slot allocation will not necessarily be equal, we define fairness in terms of the closeness of allocation to respective link demands while preserving the collision free property. The algorithm can be used in conjunction with existing link activation algorithms to provide a fairer and fuller utilization of the channel.
New therapeutic approaches for equine protozoal myeloencephalitis: pharmacokinetics of diclazuril sodium salts in horses. (2006)

Diclazuril is a triazine-based antiprotozoal agent which may have clinical application in the treatment of equine protozoal myeloencephalomyelitis (EPM). In this study, the use of the sodium salt diclazuril to increase the apparent bioavailability of diclazuril for the treatment and prophylaxis of EPM and various other Apicomplexan mediated diseases is described. In this study, diclazuril sodium salt was synthesized and administered to horses as diclazuril sodium salt formulations. The absorption, distribution, and clearance of diclazuril sodium salt in the horse are described. Diclazuril was rapidly absorbed, with peak plasma concentrations occurring at 8-24 hours following an oral mucosal administration of diclazuril sodium salt. The mean oral bioavailability of diclazuril as Clinacox was 9.5% relative to oral mucosal administration of diclazuril sodium salt. Additionally, diclazuril in DMSO administered orally was 50% less bioavailable than diclazuril sodium salt following an oral mucosal administration. It was also shown that diclazuril sodium salt has the potential to be used as a feed additive for the treatment and prophylaxis of EPM and various other Apicomplexan mediated diseases.
Wound Healing in Older Adults. (2016)

Impaired wound healing in the elderly represents a major clinical problem that is growing as our population ages. Wound healing is affected by age and by co-morbid conditions, particularly diabetes and obesity. This is particularly important in Rhode Island as the state has a very high percentage of vulnerable older adults. A multi- disciplinary approach that incorporates the skills of a comprehensive wound center with specialized nursing, geriatric medicine and palliative care will facilitate rapid wound healing, reduce costs and improve outcomes for our older adults that suffer from 'problem wounds'.
H2‐Antihistaminika, 7. Mitt. Synthese und H2‐antihistaminische Wirkung N,N′‐substituierter Thioharnstoffe, Cyanoguanidine und Dithiooxamide (1981)

Abstract Es wurden N′‐substituierte Thioharnstoffe, Cyanoguanidine und Dithiooxamide mit einem 5‐Methyl‐4‐imidazolyl‐methylthioethyl‐Substituenten dargestellt und auf H 2 ‐antihistaminische Wirksamkeit untersucht.
Effect of Sacral and Iliac Instrumentation on Strains in the Pelvis (1996)

This study suggests significant stress shielding provided by sacro and sacroiliac instrumentation systems, supporting the possibility of development of device-related osteopenia that may predispose patients to late, insufficiency-type fractures as their activity increases. The rigid instrumentation of the lumbosacral spine was found to increase the stress during torsion, which may lead to failure during activity.
Cisplatin Resistance and Transcription Factors (2005)

Cisplatin is one of the most potent and widely used anti-cancer agents in the treatment of various solid tumors. However, the development of resistance to cisplatin is a major obstacle in clinical treatment. Several mechanisms are thought to be involved in cisplatin resistance, including decreased intracellular drug accumulation, increased levels of cellular thiols, increased nucleotide excision-repair activity and decreased mismatch-repair activity. In general, the molecules responsible for each mechanism are upregulated in cisplatin-resistant cells; this indicates that the transcription factors activated in response to cisplatin might play crucial roles in drug resistance. It is known that the tumor-suppressor proteins p53 and p73, and the oncoprotein c-Myc, which function as transcription factors, influence cellular sensitivity to cisplatin. So far, we have identified several transcription factors involved in cisplatin resistance, including Y-box binding protein-1 (YB-1), CCAAT-binding transcription factor 2 (CTF2), activating transcription factor 4 (ATF4), zinc-finger factor 143 (ZNF143) and mitochondrial transcription factor A (mtTFA). Two of these-YB-1 and ZNF143-lack the high-mobility group (HMG) domain and can bind preferentially to cisplatin-modified DNA in addition to HMG domain proteins or DNA repair proteins, indicating that these transcription factors may also participate in DNA repair. In this review, we summarize the mechanisms of cisplatin resistance and focus on transcription factors involved in the genomic response to cisplatin.
Wafer-level chip-scale packaging for low-end RF products (2005)

The paper gives a short overview of wafer-level chip-scale packaging technology and analyses its added value in the packaging of RF ICs. Particularly, the possibilities of substrate crosstalk suppression by substrate thinning and trenching together with embedding of RF passives (inductors, antennas) are addressed. The Shellcase-type wafer-level packaging solution is used as a study case presenting its fabrication aspects and its potential for RF IC packaging.
Apoptosis and apoptosis-associated gene products related to the response to neoadjuvant chemotherapy for gastric cancer (2002)

To evaluate the effect of neoadjuvant chemotherapy on gastric cancer, we examined the correlation between induction of apoptosis and expression of p53, Bcl-2, and Bax. Eighty-five patients with advanced gastric cancer were retrospectively divided into the following two groups: 54 patients received 5-fluorouracil (5-FU) at 300 mg/body/day for 14 days and cisplatin (CDDP) at 15 mg/body/day for 2 days as group A; 31 patients without any preoperative chemotherapy as group B. According to histological changes in tumors due to neoadjuvant chemotherapy, the therapeutic effects on tumors were evaluated. The apoptotic index (AI) of group A was significantly higher than that of group B (1.12+/-0.40 vs. 0.67+/-0.24; p<0.01). In group A, the AI of p53-positive cases was significantly lower than that of negative cases (0.92+/-0.32 vs. 1.39+/-0.32; p<0.01). The AI of histological responders was significantly higher than that of non-responders (1.34+/-0.35 vs. 1.02+/-0.38; p<0.01). There was no significant correlation between AI and expression of Bcl-2 or Bax. In group A, histological responders, Bcl-2 positive, and high AI patients had better prognosis, respectively. In conclusion, neoadjuvant chemotherapy for gastric cancer enhanced induction of apoptosis, and AI might be useful to evaluate the effect of neoadjuvant chemotherapy.
Apolipoprotein E polymorphism is not a predictor for repeated coronary artery bypass surgery (2005)

Our results suggest that medium-term survivors after redo CABG have a strong genetic predisposition unrelated to hypercholesterolemia or apoE genotype, leading to more severe coronary artery disease at earlier age. In the older age group, redo coronary artery bypass surgery is associated with hypercholesterolemia, which, although modified by apoE genotype, may mainly be due to other genetic or acquired factors.
Two-Dimensional Electrohydrodynamically Induced Colloidal Phases (2002)

Over the past decade, experiments have shown that applied electric fields can be used to assemble colloids at electrode surfaces via an apparently electrohydrodynamic attractive interaction. Recently however, it has been seen that confinement strongly influences this process, simultaneously suppressing the apparent attractions while increasing the relative importance of field-induced dipole−dipole repulsions. By varying the degree of confinement and the strength of the applied field, one can alter the relative magnitude of these competing effects. We show here that one can take advantage of this interplay for the construction of novel two-dimensional colloidal phases.
Toward the holodeck (2001)

We describe an initial prototype of a holodeck- like environment that we have created for the Mission Rehearsal Exercise Project. The goal of the project is to create an experience learning system where the participants are immersed in an environment where they can encounter the sights, sounds, and circumstances of real-world scenarios. Virtual humans act as characters and coaches in an interactive story with pedagogical goals.
STATIC AND DYNAMIC STUDIES OF PROTEIN SORPTION BY POROUS ALKYLSILICA (1985)

ABSTRACT Porous alkylsilicas are important stationary phases (sorbents) for separating proteins by high performance liquid chromatography and have great potential for large scale isolations. We have employed batch experiments, frontal chromatography, and surface energy measurement techniques to study the factors which influence protein sorption to these materials. Proteins such as bovine serum albumin are sorbed irreversibly from phosphate buffer at pH 7 and pH 2. Addition of alcohol at sufficient concentration to reduce the surface tension of the solvent to lesis than 34 ergs/cm2 effected desorption at pH 2 but not at pH 7. Proteins were desorbed by solutions of nonionic surfactant at pH 7. The chain-lengths of alkyl groups on the silica had little influence on sorption isotherms which, in the batch studies, were of the general Langmuir shape. The isotherms derived fron the frontal experiments were indicative of two-stage desorption process.
Fiber-Based Photonic Generation of High-Frequency Microwave Pulses With Reconfigurable Linear Chirp Control (2010)

A fiber-based approach for linear and continuous chirp control in photonics microwave pulse generation is proposed and demonstrated. The technique is based on spectral pulse shaping combined with nonlinear frequency-to-time mapping (FTM). Particularly, the proposed fiber-optics method provides an unprecedented arbitrary chirp-rate control by combining spectral shaping induced by dispersion unbalance in a fiber interferometer, resulting in a nonlinear-chirp frequency interference pattern, with nonlinear FTM. Full linear chirp reconfigurability, including positive, negative and zero chirp rates, is achieved from a single fiber-optics platform by simply varying the relative delay between the interferometer arms. Moreover, a simple balanced photodetection strategy is implemented to achieve dc-free microwave pulses with significantly improved noise figures. High-quality dc-free gigahertz-frequency microwave sinusoids were successfully generated with central frequencies ranging from 100 MHz to 25 GHz and chirp rates ranging from -160 MHz/ns to +160 MHz/ns.
ChemInform Abstract: SYNTHESIS AND CHARACTERIZATION OF NIOBIUM(III) β‐DIKETONATE DERIVATIVES; MOLECULAR CONSTITUTION OF THEIR SOLUTIONS (1981)

Abstract Die Reaktion von Nb2C16L4 (L = PMe 2 Ph) mit Dipivaloylmethan in Methylenchlorid oder THF ergibt unabhängig vom stöchiometri‐ schen Reaktandenverhältnis den Monodiketonato‐Komplex (I).
Photocontrol of Chiral Recognition by Capped Cyclodextrin (1981)

Azobenzene-capped 0-cyclodextrin (1) exhibits chiral recognition in binding optical isomers of some guest molecules with stereoselectivity which inverts by photoirradiation.Cyclodextrins are cyclic oligosaccharides made up of six, seven and eight glucose residues in a molecule (a-, 0-and y-CD respectively) and can include a wide variety of organic and inorganic guests in their cavities.'In addition, they exert catalytic action on suitable included substrate molecules,mimicking enzymes. Despite rather few restrictions other than size on the type of guest molecules2 -1 6 incoyporated, stereospecific interactions have been described in some instances.Various chemical modifications have been applied to cyclodextrins to improve their catalytic activity,' but almost no effort has been invested to clarify the effect of modification on stereochemistry of CD-substrate interactions.We have recently prepared a photoresponsive capped B-CD:'6,6
Nonlinear imaging techniques for the observation of cell membrane perturbation due to pulsed electric field exposure (2014)

Nonlinear optical probes, especially those involving second harmonic generation (SHG), have proven useful as sensors for near-instantaneous detection of alterations to orientation or energetics within a substance. This has been exploited to some success for observing conformational changes in proteins. SHG probes, therefore, hold promise for reporting rapid and minute changes in lipid membranes. In this report, one of these probes is employed in this regard, using nanosecond electric pulses (nsEPs) as a vehicle for instigating subtle membrane perturbations. The result provides a useful tool and methodology for the observation of minute membrane perturbation, while also providing meaningful information on the phenomenon of electropermeabilization due to nsEP. The SHG probe Di- 4-ANEPPDHQ is used in conjunction with a tuned optical setup to demonstrate nanoporation preferential to one hemisphere, or pole, of the cell given a single square shaped pulse. The results also confirm a correlation of pulse width to the amount of poration. Furthermore, the polarity of this event and the membrane physics of both hemispheres, the poles facing either electrode, were tested using bipolar pulses consisting of two pulses of opposite polarity. The experiment corroborates findings by other researchers that these types of pulses are less effective in causing repairable damage to the lipid membrane of cells.
Energy Storage Fuel Cell Vehicle Analysis: Preprint (2005)

In recent years, hydrogen fuel cell (FC) vehicle technology has received considerable attention as a strategy to decrease oil consumption and reduce harmful emissions. However, the cost, transient response, and cold performance of FC systems may present significant challenges to widespread adoption of the technology for transportation in the next 15 years. The objectives of this effort were to perform energy storage modeling with fuel cell vehicle simulations to quantify the benefits of hybridization and to identify a process for setting the requirements of ES for hydrogen-powered FC vehicles for U.S. Department of Energy's Energy Storage Program.
Putative resolution of the EEEE selectivity paradox in L-type Ca2+and bacterial Na+biological ion channels (2016)

The highly selective permeation of ions through biological ion channels can be described and explained in terms of fluctuational dynamics under the influence of powerful electrostatic forces. Hence valence selectivity, e.g. between Ca2+ and Na+ in calcium and sodium channels, can be described in terms of ionic Coulomb blockade, which gives rise to distinct conduction bands and stop-bands as the fixed negative charge Qf at the selectivity filter of the channel is varied. This picture accounts successfully for a wide range of conduction phenomena in a diversity of ion channels. A disturbing anomaly, however, is that what appears to be the same electrostatic charge and structure (the so-called EEEE motif) seems to select Na+ conduction in bacterial channels but Ca2+ conduction in mammalian channels. As a possible resolution of this paradox it is hypothesised that an additional charged protein residue on the permeation path of the mammalian channel increases |Qf | by e, thereby altering the selectivity from Na+ to Ca2+. Experiments are proposed that will enable the hypothesis to be tested.
5G synchronization requirements and solutions (2021)

Accurate and reliable synchronization has long been a fundamental prerequisite for the correct operation of telecommunications networks. Its importance has grown in 4G, and it will be more important than ever in 5G and future networks.
Ariadne's ChemEffect and Pathway Studio knowledge base (2009)

Integrated literature-derived protein and chemical knowledge bases can rationalize many aspects of drug development process including drug repositioning and biomarker design.
Expression of p16Ink4a Compensates for p18Ink4c Loss in Cyclin-Dependent Kinase 4/6–Dependent Tumors and Tissues (2007)

Cell cycle progression from G(1) to S phase depends on phosphorylation of pRb by complexes containing a cyclin (D type or E type) and cyclin-dependent kinase (e.g., cdk2, cdk4, or cdk6). Ink4 proteins function to oppose the action of cdk4/6-cyclin D complexes by inhibiting cdk4/6. We employed genetic and pharmacologic approaches to study the interplay among Ink4 proteins and cdk4/6 activity in vivo. Mouse embryo fibroblasts (MEF) lacking p16(Ink4a) and p18(Ink4c) showed similar growth kinetics as wild-type MEFs despite increased cdk4 activity. In vivo, germline deficiency of p16(Ink4a) and p18(Ink4c) resulted in increased proliferation in the intermediate pituitary and pancreatic islets of adult mice, and survival of p16(Ink4a-/-);p18(Ink4c-/-) mice was significantly reduced due to aggressive pituitary tumors. Compensation among the Ink4 proteins was observed both in vivo in p18(Ink4c-/-) mice and in MEFs from p16(Ink4a-/-), p18(Ink4c-/-), or p16(Ink4a-/-);p18(Ink4c-/-) mice. Treatment with PD 0332991, a specific cdk4/6 kinase inhibitor, abrogated proliferation in those compartments where Ink4 deficiency was associated with enhanced proliferation (i.e., islets, pituitary, and B lymphocytes) but had no effect on proliferation in other tissues such as the small bowel. These data suggest that p16(Ink4a) and p18(Ink4c) coordinately regulate the in vivo catalytic activity of cdk4/6 in specific compartments of adult mice.
Chlorine inactivation of hepatitis E virus and human adenovirus 2 in water (2014)

Hepatitis E virus (HEV) is transmitted via the fecal-oral route and has been recognized as a common source of large waterborne outbreaks involving contaminated water in developing countries. Thus, there is the need to produce experimental data on the disinfection kinetics of HEV by chlorine in water samples with diverse levels of fecal contamination. Here, the inactivation of HEV and human adenovirus C serotype 2 (HAdV2), used as a reference virus, was monitored using immunofluorescence and quantitative reverse transcription polymerase chain reaction (RT-qPCR) assays. HEV has been shown to be susceptible to chlorine disinfection and presented equivalent kinetics to human adenoviruses. The C(t) values observed for a 2-log reduction of HEV were 0.41 in buffered demand-free water and 11.21 mg/L × min in the presence of 1% sewage. The results indicate that the inactivation kinetics of HEV and HAdV2 are equivalent and support the use of chlorine disinfection as an effective strategy to control HEV waterborne transmission.