gebhart/patrepeval huggingface dataset:
Effect of Adrenaline on Thrombosthenin (1971)

Summary It has been found that adrenaline protects the two activities of thrombosthenin from inhibition by NEM if added before or with NEM but not if added after. The α-blockers of epinephrine, phentolamine, abolishes the protective effect of adrenaline when it is added before adrenaline. We find the same results with noradrenaline but not with 5-hydroxytryptamine. A parallemism exists between the effect of adrenaline on thrombosthenin and clot retraction, but not on platelet aggregation. This shows possibly that the activities of thrombosthenin are directly linked to clot retraction, but in platelet aggregation it seems that thrombosthenin is necessary but not sufficient.
ORIGINAL COMMUNICATION Influence of alcohol consumption on immunological status: a review (2002)

The aim of this review is to present and discuss the effect of different levels of alcohol consumption on the immune system. Not only the amount consumed but also the type of alcoholic beverage have to be taken into account in order to determine the consequences on activity, number, distribution, balance, interaction and response of immunocompetent cells. The association between alcohol exposure and the risk of developing an alcohol-related disease is multifactorial. In fact, age, gender, smoking habits, dietary intake and exercise are involved among other factors. The evaluation of the host cellular and humoral immune responses has shown that alcohol may induce some benefits when consumption is moderate. Moreover, those alcoholic beverages that contain antioxidants, such as red wine, could be protectors against immune cell damage. According to the literature consulted, the daily consumption of 10 – 12 g and 20 – 24 g of alcohol for women and men, respectively, is considered to be a moderate intake; the type of beverage has been established not to be important when defining moderation. Particular attention is often focused on the Uor J-shaped curve which also suggests that light to moderate drinking produces a protective effect. Such an inverse relationship indicates a reduction of risk for both light and moderate consumers and a higher risk not only for hard drinkers, but also for non-consumers. European Journal of Clinical Nutrition (2002) 56, Suppl 3, S50 – S53. doi:10.1038=sj.ejcn.1601486
0.61THz radiating source with on-chip antenna on 65nm CMOS (2016)

This paper presents a 615GHz radiating source (609-624GHz) based on a differential Colpitts oscillator with an on-chip antenna in 65nm CMOS. The source radiates the 5 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sup> harmonic of the oscillation frequency, which is also generated in the voltage controlled oscillator (VCO) itself due to its large voltage signal. An integrated loop antenna serves also as the load inductance at the drains of the VCO core transistors, acting as a choke at the fundamental tone and a matched antenna at the 5 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sup> harmonic. This radiating source achieves a total radiated power (TRP) of -23dBm, an EIRP of -13.7dBm with DC-consumption of 17mW from 1.4V DC supply and a silicon area of 0.164mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . Its peak EIRP and total radiated power are the highest among all lens-less silicon based signal generation circuits operating at frequencies beyond 550GHz.
Abstract 2284: Dissecting signaling networks involved in the tumor-microenvironment crosstalk in chronic lymphocytic leukemia (CLL) (2010)

Abstract Crosstalk between tumor cells and the microenvironment is often a prerequisite for carcinogenesis. CLL, the most common leukemia in the western world, is an excellent model system to investigate this microenvironmental crosstalk. The dependence of the CLL cells for pro-survival support from the microenvironment is apparent from the induction of rapid spontaneous apoptosis in CLL cells in vitro unless they are cultured on feeder cells or treated with microenvironmental cytokines. CLL cells are also capable of inducing other non-malignant microenvironmental cells to form a pro-survival niche. We have used a tripartite strategy to characterize the interaction between CLL cells and their microenvironment. Firstly, we have quantified the interaction of pro-survival ligand-receptor pairs and their dose-response curves in primary CLL cells and non-malignant B cells. Of the ligand-receptor pairs tested, IL4 and CD40L were found to rescue primary CLL cells most effectively from apoptosis. The effector dependence of IL4 and CD40L displayed different saturation curves in CLL versus non-malignant B cells, pointing towards distinct differences in ligand-receptor interactions. Secondly, we have used a systems biology approach to identify central nodes in the survival network induced by the microenvironment. The model is generated from the kinetics of the transcriptome acquired from gene expression profiling CLL cells after microenvironmental stimulation. Via a procedure that involves gene-ranking, significance filtering and kinetic classification, deregulated genes have been identified. Model construction using these genes will yield central nodes which will be functionally validated on a cohort of patients. As a third approach, the pro-survival niche inducing property of CLL cells on other microenvironmental cells is studied by gene expression profiling differentiated monocytes, which arise when monocytes are cocultured with CLL cells (which support CLL survival) versus the differentiated monocytes which arise when cultured with non-malignant B cells. Analysis of the gene expression profiles revealed genes specifically deregulated due to the effect of CLL cells. This study will give us a deep insight into the signaling networks operating between the tumor and its microenvironment. This is certainly important for the identification of drug targets which can abrogate this interaction and thereby reduce the viability of the CLL cells in vivo. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2284.
A simple and scalable approach to hollow silicon nanotube (h-SiNT) anode architectures of superior electrochemical stability and reversible capacity (2015)

A simple, facile, and more importantly, recyclable sacrificial template based approach involving magnesium oxide (MgO) nanorods for producing scalable quantities of hollow silicon nanotubes (h-SiNTs) architectures is discussed in this report.
Synergic Effects of Rehabilitation and Intravenous Infusion of Mesenchymal Stem Cells After Stroke in Rats (2016)

Abstract Background Intravenous infusion of mesenchymal stem cells (MSCs) derived from adult bone marrow improves behavioral function in rat stroke models. Rehabilitation therapy through physical exercise also provides therapeutic efficacy for cerebral ischemia. Objective The purpose of this study was to investigate whether synergic effects of daily rehabilitation and intravenous infusion of MSCs has therapeutic effects after stroke in rats. Design This was an experimental study. Methods A permanent middle cerebral artery occlusion (MCAO) was induced by intraluminal vascular occlusion with a microfilament. Four experimental groups were studied: group 1 (vehicle only, n=10), group 2 (vehicle + exercise, n=10), group 3 (MSCs only, n=10), and group 4 (MSCs + exercise, n=10). Rat MSCs were intravenously infused at 6 hours after MCAO, and the rats received daily rehabilitation with treadmill running exercise for 20 minutes. Lesion size was assessed at 1, 14, and 35 days using magnetic resonance imaging. Functional outcome was assessed using the Limb Placement Test. Results Both combined therapy and MSC infusion reduced lesion volume, induced synaptogenesis, and elicited functional improvement compared with the groups without MSC infusion, but the effect was greater in the combined therapy group. Limitations A limitation of this study is that the results were limited to an animal model and cannot be generalized to humans. Conclusions The data indicate that the combined therapy of daily rehabilitation and intravenous infusion of MSCs improved functional outcome in a rat MCAO model.
Treatment of stem fractures in tumor prostheses by connecting different systems with a special adapter / Behandlung von Schaftfrakturen bei Tumorprothesen durch Kopplung verschiedener Prothesensysteme mit einem speziellen Adapter (2009)

In long-term survivors, oncologic surgeons are regularly faced with the problem of revising stem breakage of first generation Kotz modular femoral and tibial reconstruction system (KMFTR) prostheses. To avoid a whole prosthesis-exchange, we invented an adapter which allows connecting original KMFTR devices to new modular universal tumor and revision system (MUTARS) components. The adapter was used in 10 patients after a mean time span of 16.6 years after primary implantation of KMFTR prostheses. Reasons for revision included femoral stem breakage in five cases, breakage of tibial component in three cases and periprosthetic fracture in two cases (one femoral, one tibial). The femoral stem (three cases), the tibial stem (two cases) or the tibial plateau and body (two cases) were exchanged to MUTARS and connected to the remaining KMFTR parts. Three cases were converted to a total femur. Postoperative complications included one cone-dislocation and one aseptic loosening. In all patients, the pre-incidence function could be restored. The mean Musculoskeletal Tumor Society score was 81.7% of normal function. The presented adapter enables restoration of the long-term extremity function with relatively minor revision.
Inhibition of 2-oxoglutarate dependent oxygenases (2011)

2-Oxoglutarate (2OG) dependent oxygenases are ubiquitous iron enzymes that couple substrate oxidation to the conversion of 2OG to succinate and carbon dioxide. In humans their roles include collagen biosynthesis, fatty acid metabolism, DNA repair, RNA and chromatin modifications, and hypoxic sensing. Commercial applications of 2OG oxygenase inhibitors began with plant growth retardants, and now extend to a clinically used pharmaceutical compound for cardioprotection. Several 2OG oxygenases are now being targeted for therapeutic intervention for diseases including anaemia, inflammation and cancer. In this critical review, we describe studies on the inhibition of 2OG oxygenases, focusing on small molecules, and discuss the potential of 2OG oxygenases as therapeutic targets (295 references).
Supplementary Table 4 from Cancer Immunotherapy Based on Killing of <i>Salmonella</i>-Infected Tumor Cells (2023)

Supplementary Table 4 from Cancer Immunotherapy Based on Killing of &lt;i&gt;Salmonella&lt;/i&gt;-Infected Tumor Cells
Shelf-life stability of flavoured pinto bean [Phaseolus vulgaris] and field pea [Pisum sativum] extrudates (1995)

Snacks from whole pinto bean and field pea flours were produced by high temperature extrusion using Wenger TX-52 twin screw extruder. Seasonings were blended into the flours before extrusions. Flavouring of extruded snacks was accomplished by first applying a fine spray of Canola oil (10% of puffs weight), followed by coating them with cheese powder (l5%). Shelf-life stability of extruded products showed very high microbiological quality after processing and during 6 months of storage. Also no significant changes in peroxide and acid values were noted for the same period of time. Storage time did not influence texture of the extrudates. Some improvement was observed in in vitro protein digestibility for some of the snacks made from field pea
Publish Subscribe on Large-Scale Dynamic Topologies: Routing and Overlay Management (2006)

Content-based publish-subscribe is emerging as a communication paradigm able to meet the demands of highly dynamic distributed applications, such as those made popular by mobile computing and peer-to-peer networks. Nevertheless, the available systems implementing this communication model are still unable to cope efficiently with dynamic changes to the topology of their distributed dispatching infrastructure. This hampers their applicability in the aforementioned scenarios. This thesis addresses this problem and presents a complete approach to the reconfiguration of content-based publish-subscribe systems. In Part I, it proposes a layered architecture for reconfigurable publish-subscribe middleware consisting of an overlay, a routing, and an event-recovery layer. This architecture allows the same routing components to operate in different types of dynamic network environments, by exploiting different underlying overlays. Part II addresses the routing layer with new protocols to manage the recon- figuration of the routing information enabling the correct delivery of events to subscribers. When the overlay changes as a result of nodes joining or leaving the network or as a result of mobility, this information is updated so that routing can adapt to the new environment. Our protocols manage to achieve this with as little overhead as possible. Part III addresses the overlay layer and proposes two novel approaches for building and maintaining a connected topology in highly dynamic network sce- narios. The protocols we present achieve this goal, while managing node degree and keeping reconfigurations localized when possible. These properties allow our overlay managers to be applied not only in the context of publish-subscribe mid- dleware but also as enabling technologies for other communication paradigms like application-level multicast. Finally, the thesis integrates the overlay and routing layers into a single frame- work and evaluates their combined performance both in wired and in wireless scenarios. Results show that the optimizations provided by our routing reconfig- uration protocols allow the middleware to achieve very good performance in such networks. Moreover, they highlight that our overlay layer is able to optimize this performance even further, significantly reducing the network traffic generated by the routing layer. The protocols presented in this thesis are implemented in the REDS middle- ware framework developed at Politecnico di Milano. Their use enables REDS to operate efficiently in dynamic network scenarios ranging from large-scale peer-to- peer to mobile ad hoc networks.
MK5 haplodeficiency attenuates hypertrophy and preserves diastolic function during remodeling induced by chronic pressure overload in the mouse heart (2017)

MAPK-activated protein kinase-5 (MK5) is a protein serine/threonine kinase that is activated by p38 MAPK and the atypical MAPKs ERK3 and ERK4. The physiological function(s) of MK5 remains unknown. Here, we examined the effect of MK5 haplodeficiency on cardiac function and myocardial remodeling. At 12 wk of age, MK5 haplodeficient mice (MK5<sup>+/-</sup>) were smaller than age-matched wild-type littermates (MK5<sup>+/+</sup>), with similar diastolic function but reduced systolic function. Transverse aortic constriction (TAC) was used to induce chronic pressure overload in 12-wk-old male MK5<sup>+/-</sup> and MK5<sup>+/+</sup> mice. Two weeks post-TAC, heart weight-to-tibia length ratios were similarly increased in MK5<sup>+/-</sup> and MK5<sup>+/+</sup> hearts, as was the abundance of B-type natriuretic peptide and β-myosin heavy chain mRNA. Left ventricular ejection fraction was reduced in both MK5<sup>+/+</sup> and MK5<sup>+/-</sup> mice, whereas regional peak systolic tissue velocities were reduced and isovolumetric relaxation time was prolonged in MK5<sup>+/+</sup> hearts but not in MK5<sup>+/-</sup> hearts. The TAC-induced increase in collagen type 1-α<sub>1</sub> mRNA observed in MK5<sup>+/+</sup> hearts was markedly attenuated in MK5<sup>+/-</sup> hearts. Eight weeks post-TAC, systolic function was equally impaired in MK5<sup>+/+</sup> and MK5<sup>+/-</sup> mice. In contrast, the increase in E wave deceleration rate and progression of hypertrophy observed in TAC MK5<sup>+/+</sup> mice were attenuated in TAC MK5<sup>+/-</sup> mice. MK5 immunoreactivity was detected in adult fibroblasts but not in myocytes. MK5<sup>+/+</sup>, MK5<sup>+/-</sup>, and MK5<sup>-/-</sup> fibroblasts all expressed α-smooth muscle actin in culture. Hence, reduced MK5 expression in cardiac fibroblasts was associated with the attenuation of both hypertrophy and development of a restrictive filling pattern during myocardial remodeling in response to chronic pressure overload.<b>NEW & NOTEWORTHY</b> MAPK-activated protein kinase-5 (MK5)/p38-regulated/activated protein kinase is a protein serine/threonine kinase activated by p38 MAPK and/or the atypical MAPKs ERK3 and ERK4. MK5 immunoreactivity was detected in adult ventricular fibroblasts but not in myocytes. MK5 haplodeficiency attenuated the progression of hypertrophy, reduced collagen type 1 mRNA, and protected diastolic function in response to chronic pressure overload.
[Facial circumscribed ossifying myositis. Anatomo-clinical and tomodensitometric study]. (1989)

1 case of circumscribed myositis ossificans of the temporal muscle is reported in a 21 years-old man. The initial complaint was a sudden non traumatic swelling. Roentgenography showed a characteristic feature: peripheral radio-opacity around a non-opacified area. Under microscope, we could find 3 zones: a central fibroblastic area, an intermediate zone with immature osteoid bone, a peripheral zone with mature lamellar bone. In addition, we used histoenzymological and electron microscopical methods. The difficulties of diagnosis, the pathogenesis and the prognosis of this disease were also discussed.
Split Packing: Algorithms for Packing Circles with Optimal Worst-Case\n Density (2017)

In the classic circle packing problem, one asks whether a given set of\ncircles can be packed into a given container. Packing problems like this have\nbeen shown to be $\\mathsf{NP}$-hard. In this paper, we present new sufficient\nconditions for packing circles into square and triangular containers, using\nonly the sum of the circles' areas: For square containers, it is possible to\npack any set of circles with a combined area of up to approximately 53.90% of\nthe square's area. And when the container is a right or obtuse triangle, any\nset of circles whose combined area does not exceed the triangle's incircle can\nbe packed.\n These area conditions are tight, in the sense that for any larger areas,\nthere are sets of circles which cannot be packed. Similar results have long\nbeen known for squares, but to the best of our knowledge, we give the first\nresults of this type for circular objects.\n Our proofs are constructive: We describe a versatile,\ndivide-and-conquer-based algorithm for packing circles into various container\nshapes with optimal worst-case density. It employs an elegant subdivision\nscheme that recursively splits the circles into two groups and then packs these\ninto subcontainers. We call this algorithm "Split Packing". It can be used as a\nconstant-factor approximation algorithm when looking for the smallest container\nin which a given set of circles can be packed, due to its polynomial runtime.\n A browser-based, interactive visualization of the Split Packing approach and\nother related material can be found at https://morr.cc/split-packing/\n
Pharmacophore alignment search tool: Influence of canonical atom labeling on similarity searching (2010)

Previously, (Hähnke et al., J Comput Chem 2009, 30, 761) we presented the Pharmacophore Alignment Search Tool (PhAST), a ligand-based virtual screening technique representing molecules as strings coding pharmacophoric features and comparing them by global pairwise sequence alignment. To guarantee unambiguity during the reduction of two-dimensional molecular graphs to one-dimensional strings, PhAST employs a graph canonization step. Here, we present the results of the comparison of 11 different algorithms for graph canonization with respect to their impact on virtual screening. Retrospective screenings of a drug-like data set were evaluated using the BEDROC metric, which yielded averaged values between 0.4 and 0.14 for the best-performing and worst-performing canonization technique. We compared five scoring schemes for the alignments and found preferred combinations of canonization algorithms and scoring functions. Finally, we introduce a performance index that helps prioritize canonization approaches without the need for extensive retrospective evaluation.
Changes in serum lipoprotein profile during interferon therapy in chronic hepatitis C (2001)

Therapy with a interferon is associated with a rise in serum triglyceride levels, although this effect has not been well studied with newer forms of interferon or interferon in combination with ribavirin.Review of combined data obtained from several prospective, randomized controlled clinical trials conducted in the clinical studies unit of a tertiary care referral center among patients with chronic hepatitis C undergoing treatment with various forms of a interferon, with or without the addition of ribavirin. Serum levels of triglycerides and cholesterol were measured before and during therapy. Changes in these levels were correlated with baseline characteristics.At baseline, the mean serum triglyceride level among 152 patients studied was 130 mg/dL (range 32-620) and was elevated above normal in three patients (2%). During therapy, triglyceride levels rose significantly early on and began to decline spontaneously after 12 wk, returning to baseline after stopping treatment. Triglyceride levels rose above 500 mg/dL in 18 patients (12%) and above 1000 mg/dL in two patients (1.3%) although none experienced acute complications or clinical symptoms. Serum cholesterol levels did not change significantly during therapy (mean at baseline 172 vs 168 mg/dL at 24 wk). Factors correlated with the rise in triglycerides included baseline triglyceride levels, HCV genotype, and the type of interferon used.Serum triglyceride levels increase consistently in patients with chronic hepatitis C treated with all forms of a interferon, often to very high levels. These changes do not seem to be associated with clinical signs or complications and triglyceride levels decline while patients are still on therapy and return to normal after stopping.
A single-arm, multicenter, phase II trial of osimertinib in patients with epidermal growth factor receptor exon 18 G719X, exon 20 S768I, or exon 21 L861Q mutations (2023)

This trial suggests osimertinib has activity in patients with these uncommon EGFR mutations.