gebhart/patrepeval huggingface dataset:
The SESAME Experience: from Assembly Languages to Declarative Models (2006)

SESAME (Software Environment for Software Analysis by Mutation Effects) is a fault injection tool using mutation as the target fault model. It has been used for 15 years to support dependability research at LAAS-CNRS. A salient feature of SESAME is that it is multi-language. This made it possible to inject faults into software written in assembly languages, procedural languages (Pascal, C), a data-flow language (LUSTRE), as well as in a declarative language for temporal planning in robotics. This paper provides an overview of the tool, and reports on its use in experimental research addressing either fault removal or fault tolerance topics.
Liver Fatty Acid-binding Protein as a Sensitive Serum Marker of Acute Hepatocellular Damage in Liver Transplant Recipients (2002)

Serum tests of acute hepatocellular injury are commonly used to investigate the presence and monitor the progress of liver disease (1)(2). The release of cytoplasmic proteins from damaged hepatocytes into the vascular system follows tissue necrosis caused by, e.g., acetaminophen intoxication, ischemia and reperfusion injury, or rejection after liver transplantation. Although the hepatocytes are in direct contact with the vasculature and no interstitial barrier is between the two, smaller proteins appear earlier in the circulation than do larger ones (1) and would therefore increase earlier in serum above their upper reference value after an acute hepatocellular injury. α-Glutathione S -transferase (α-GST; 26 kDa) is a more sensitive and specific marker of hepatocellular damage (3)(4) than either alanine transaminase (ALT; 96 kDa) or aspartate transaminase. α-GST is present in liver, kidney, and intestine; is released rapidly from damaged hepatocytes; and has a relatively short in vivo plasma half-life (3)(4). The use of α-GST for the detection of hepatocellular injury secondary to acute rejection after liver transplantation improved the biochemical monitoring of patients and decreased mortality and morbidity (3). In search of even smaller and more specific cytoplasmic proteins for the detection of liver injury, we have studied the liver-type fatty acid-binding protein (L-FABP). FABPs are a family of 15-kDa proteins that are involved in the intracellular transport of long-chain fatty acids (5). To date, nine different FABPs have been identified and named according to the tissues in which they were first identified (5). L-FABP occurs mainly in the liver but, in small quantities, also in kidney and small intestine. In the hepatic lobule, L-FABP is expressed in hepatocytes in a declining portal-to-central gradient (5)(6). Extensive studies …
The Shoulder. Ed. 2, vols. 1 and 2 (1998)

JBJS was founded by the American Orthopaedic Association in 1903 and is the Official Journal of the American Orthopaedic Association. EXCELLENCE THROUGH PEER REVIEW The Journal of Bone & Joint Surgery (JBJS) has been the most valued source of information for orthopaedic surgeons and researchers for over 125 years and is the gold standard in peer-reviewed scientific information in the field. A core journal and essential reading for general as well as specialist orthopaedic surgeons worldwide, JBJS publishes evidence-based research to enhance the quality of care for orthopaedic patients. Standards of excellence and high quality are maintained in everything we do, from the science of the content published to the customer service we provide. JBJS is an independent, non-profit journal. JBJS.org is the version of record of The Journal of Bone & Joint Surgery. JBJS is published twice a month on the first and third Wednesday of each month, each time adding to a comprehensive PDF archive dating back to 1889. Additional features online include: article commenting, social sharing links, instructional videos, podcasts, and continuing medical education activities. Contributions from anywhere in the world are welcome and considered on their merits. The manuscript must be written in English and should be submitted as outlined in the Instructions for Authors. Manuscripts are subject to blinded peer review by experts and a final decision by the editor. Papers are judged by the quality and relevance of the work. Our aim is to publish the best material available from anywhere in the world.
Comparison of interannual snowmelt-onset dates with atmospheric conditions (2001)

Abstract The snowmelt-onset date represents an important transitional point in the Arctic surface energy balance, when albedo decreases and energy absorption increases rapidly in response to the appearance of liquid water. Interannual variations in snowmelt onset are likely related to large-scale variations in atmospheric circulation, such as described by the Arctic Oscillation (AO). This research therefore examines the relationship between monthly-averaged AO values and mean annual snowmelt-onset dates over Arctic sea ice in 13 regions, from 1979 to 1998. The objective is to statistically relate variations in mean annual regional snowmelt-onset dates to variations in the AO. Additionally, monthly-averaged 500 hPa heights and 2 m air temperatures are used to illustrate a physical link between snow-melt onset and a positive AO phase. Regression analyses demonstrate that variations in the AO explain a significant portion of the variations in snowmelt onset in the West Central Arctic, Laptev Sea, East Siberian Sea, Hudson Bay and Baffin Bay. Synoptic analyses suggest earlier (later) than average snowmelt onset occurs where warm (cold) air advection and increased (decreased) cyclonic activity are present.
Antibody Response in Immunocompromised Patients With Hematologic Cancers Who Received a 3-Dose mRNA-1273 Vaccination Schedule for COVID-19 (2022)

EudraCT Identifier: 2021-001072-41.
DNA binding by adenosine cyclic 3',5'-monophosphate dependent protein kinase from calf thymus nuclei (1975)

Cyclic adenosine 3',5'-monophosphate (cAMP) dependent protein kinase and proteins specifically binding cAMP have been extracted from calf thymus nuclei and analyzed for their abilities to bind to DNA. Approximately 70% of the cAMP-binding activity in the nucleus can be ascribed to a nuclear acidic protein with physical and biochemical characteristics of the regulatory (R) subunit of cAMP-dependent protein kinase. Several peaks of protein kinase activity and of cAMP-binding activity are resolved by affinity chromatography of nuclear acidic proteins on calf thymus DNA covalently linked to aminoethyl Sephrarose 4B. When an extensively purified protein kinase is subjected to chromatography on the DNA column in the presence of 10(-7) M cAMP, the R subunit of the kinase is eluted from the column at 0.05 M NaCl while the catalytic (C) subunit of the enzyme is eluted at 0.1-0.2 M NaCl. When chromatographed in the presence of histones, the R subunit is retained on the column and is eluted at 0.6-0.9 M NaCl. In the presence of cAMP, association of the C subunit with DNA is enhanced, as determined by sucrose density gradient centrifugation of DNA-protein kinase complexes. cAMP increases the capacity of the calf thymus cAMP-dependent protein kinase preparation to bind labeled calf thymus DNA, as determined by a technique employing filter retention of DNA-protein complexes. This protein kinase preparation binds calf thymus DNA in preference to salmon DNA, Escherichia coli DNA, or yeast RNA. Binding of protein kinases to DNA may be part of a mechanism for localizing cyclic nucleotide stimulated protein phosphorylation at specific sites in the chromatin.
A comparison of placebo effects in clinical analgesic trials versus studies of placebo analgesia (2002)

A previous meta-analysis of clinical analgesic trial studies showed generally low magnitudes of placebo analgesia (N. Engl. J. Med. 344 (2001) 1594). However, as studies included in their analysis used only placebo as a control condition, we conducted two meta-analyses, one in which 23 studies used only placebo as a control condition, and one in which 14 studies investigated placebo analgesic mechanisms. Magnitudes of placebo analgesic effects were much higher in the latter (mean effect size=0.95) as compared to the former (mean effect size=0.15) and were significantly different (P=0.003). This difference as well as differences in effect sizes within studies of placebo mechanisms may be parsimoniously explained by differences in expected pain levels produced by placebo suggestions and by conditioning. Furthermore, some of the studies of placebo analgesic mechanisms indicate that the magnitude of placebo analgesia is higher when the placebo analgesic effect is induced via suggestion combined with conditioning than via suggestion alone or conditioning alone. Based on these findings, we suggest that placebo analgesic effects are most optimally conceptualized in terms of perception of the placebo agent, and therefore a new definition of placebo response is proposed.
ChemInform Abstract: First Example of Epibromohydrin as an Acetone Equivalent. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
External Corrosion Direct Assessment (ECDA) for Aboveground Storage Tank Bottoms (2007)

Abstract Direct assessment (DA) has been effectively used to evaluate the integrity of external aboveground storage tank (AST) bottoms. When cathodic protection (CP) is applied to the external surfaces of the AST bottoms, the corrosion rate can essentially be set to zero, per American Petroleum Institute (API) 653, extending the tank internal inspection intervals up to 20 years (1). AST bottoms have a practical limited time when they can be assessed. DA of AST bottoms will greatly improve the chances of detecting and preventing corrosion failures prior to the next scheduled internal inspection.
Film-Cooling Effectiveness With Injection Through a Porous Section (1965)

An experimental study of the effectiveness of film cooling following secondary air injection through a porous section into a turbulent free stream is presented. Boundary-layer velocity and temperature profiles are described. The adiabatic wall temperatures are presented in terms of the film-cooling effectiveness. The effects of varying the secondary air temperature, the blowing rate, and the free-stream velocity are studied. It is found that the protection given to a surface downstream of a porous section through which air is injected compares favorably to earlier studies where the secondary air was injected nearly tangential to the surface.
Using Meta-Agents for Multi-Agents in Networks (2007)

In this paper, we propose an approach usingmeta-agents for monitoring multi-agents and controllingtheir behaviour while moving between states in a network.The meta-agents are built on the agents in ...
Multiscale dimensional tolerance specifications established on shrinkage assessment in ceramic micro injection molding (2018)

Taking advantage of a micro powder injection molding production of a critical functional component in a miniaturized mechanism, a method for the formulation of specification intervals was developed, based on the evaluation of the shrinkage. The synthesis allows to allocate tolerance intervals according to a desired risk of rejecting parts in future evaluations. Such specifications are formulated as a function of the shrinkage, optimizing its impact on different features of size independently of their shapes or dimensions. The method is of general validity for any molding process where the material undergoes a change in dimensions due to a phase transformation.
Importance of Tyr310 residue in the third repeat of microtubule binding domain for filament formation of tau protein (2009)

The inhibition of tau fibrillation is a potential therapeutic target for Alzheimer's and other neurodegenerative diseases. As a series of studies on inhibiting the transition of soluble monomeric tau into mature fibril, the effect of Tyr310 residue in the third repeat (R3) of the microtubule-binding domain (MBD) on the assembly of MBD was investigated using Tyr-substituted MBD mutants by fluorescence, circular dichroism spectroscopy and electron microscopy. Consequently, the importance of the Tyr residue located at position 310, not at other positions, was clearly shown. The conformational comparison of the Tyr310Ala-substituted R3 repeat peptide with the unsubstituted one showed that the Tyr residue contributes to the rigid extended structure of the N-terminal V(306)QIVYK(311) sequence, and its replacement by Ala leads to the deformation of the extended structure, consequently losing its aggregation ability. The present results indicate that a compound that interacts specifically with the Tyr residue or an antibody recognizing the region containing the Tyr residue becomes a candidate for inhibiting tau fibrillation.
Psychological consequences of COVID-19 home confinement: The ECLB-COVID19 multicenter study (2020)

The ECLB-COVID19 survey revealed an increased psychosocial strain triggered by the home confinement. To mitigate this high risk of mental disorders and to foster an Active and Healthy Confinement Lifestyle (AHCL), a crisis-oriented interdisciplinary intervention is urgently needed.
Understanding Ebola virus and other zoonotic transmission risks through human–bat contacts: Exploratory study on knowledge, attitudes and practices in Southern Cameroon (2019)

The ecology of Ebola virus (EBV) remains largely unknown, but the previous detection of viral RNA and anti-EBV antibodies in African bats suggests that they might play a role in the EBV reservoir. Moreover, African bats also carry other potentially zoonotic agents such as Henipah-like viruses, coronaviruses and lyssaviruses. Today only little information is available on interactions between humans and bats. The objective of our exploratory study was to describe the extent and modes of contacts between humans and bats in southern Cameroon, considered as an area at risk for future EBV outbreaks. The survey was conducted in 11 villages of four distinct rural areas in southern Cameroon. A total of 135 respondents were interviewed using semi-structured questionnaires, between February and May 2017. The study showed that direct contacts between bats and humans are relatively common. Bat bushmeat appeared to be an occasional meat resource; 40% of respondents consume bats with a median annual consumption of three, and 28% of respondents hunt them. About 22% of the respondents reported children catching bats. Indirect contact also appeared to be common; 55% of hunters use caves as shelters and 67% of interviewees eat fruits previously chewed by bats. Bat consumption varied significantly between regions (from 0% to 87%) and between pygmies and bantus in the extreme south-east of Cameroon. The study revealed considerable diversity in practices among interviewees, most of them being subsistence cultivators and relying on self-hunted bushmeat. Geographical diversity of contacts and perceptions regarding bats in Cameroon emphasizes the need to adjust zoonotic pathogen surveillance and education campaigns to the specificities of the communities and their context of interaction with wildlife.
Supplementary Information from p53 Nongenotoxic Activation and mTORC1 Inhibition Lead to Effective Combination for Neuroblastoma Therapy (2023)

&lt;p&gt;Supplementary Material and Figures "clean"&lt;/p&gt;
Deep level trapped defect analysis in CH3NH3PbI3 perovskite solar cells by deep level transient spectroscopy (2017)

We report the presence of defects in CH<sub>3</sub>NH<sub>3</sub>PbI<sub>3</sub>, which is one of the main factors that deteriorates the performance of perovskite solar cells.
Panicum rigidulum Bosc ex Nees (2006)

https://thekeep.eiu.edu/herbarium_specimens_byname/13670/thumbnail.jpg
Filling in scenes by propagating probabilities through layers and into appearance models (2002)

Inferring the identities and positions of multiple occluding objects in a noisy image is a difficult problem, even when the shapes and appearances of the allowable objects are known. Methods that detect and analyze shape features, occlusion boundaries and optical flow break down when the image is noisy. In situations where we know the boundaries and appearances of the allowable objects, a brute force method can be used to perform MAP inference. If there are K possible objects (including translations, etc.) in up to L layers, the number of possible configurations of the scene is K/sup L/, so exact inference is intractable for large numbers of objects and reasonably large numbers of layers. We construct a Bayesian network that describes the occlusion process and we use iterative probability propagation to approximately recover the identities and positions of the objects in the scene in time that is linear in K and L. Although iterative probability propagation is an approximate inference technique, it was recently used to obtain the world record in error-correcting decoding. Experiments show that when one explanation of the scene is most probable, the algorithm finds the solution. For a small problem, we show that as the number of iterations increases, iterative probability propagation performs better than a greedy technique and becomes closer to the exact MAP algorithm. Quite surprisingly, we also find that when the order of occlusion is ambiguous, the output of the algorithm may oscillate between plausible interpretations of the scene.
Immune complex detection by immunofluorescence on polymorphonuclear leucocytes. (1977)

Polymorphonuclear leucocytes (PMN) from patients with systemic lupus erythematosus (SLE) were isolated from defibrinated and heparinized blood. In addition, PMN from a healthy donor were incubated with sera from SLE patients and with sera containing artificially prepared immune complexes of hepatitis B surface antigen (HBsAg) and human anti-HBsAg immunoglobulin (anti-HBs) with well defined variations of the antigen/antibody ratio. To one group of blood samples, 5 mM monoiodine acetic acid (MIAA) was added to block in vitro phagocytosis. The Pmn were examined for the presence of IgG, IgM, and HBsAg by the immunofluorescence technique. PMN from defibrinated blood of SLE patients showed in up to 80% immunoglobulin (Ig)-inclusions. However, addition of 5 mM MIAA reduced the number of Ig-containing PMN to at most 40%, which levels were equal to numbers found in specimens from heparinized blood. Addition of 5 mM MIAA to heparinized blood did not reduce the number of PMN with Ig inclusions. Normal donor PMN isolated from defibrinated, heparinized, and EDT blood showed equal amounts of Ig inclusions after incubation with SLE sera, but none when MIAA had been added. In PMN incubated with HBsAg-anti HBs immune complexes with an antigen antibody ratio between 5 and 0-2, both HBsAg and IgG could be detected. It is concluded that Ig inclusions in PMN from heparinized blood from SLE patients are due to in vivo phagocytosis, presumably of circulating immune complexes. In vitro phagocytosis of Ig from SLE sera by normal donor PMN also suggests the presence of immune complexes. Dependent on the antigen-antibody ratio, artificial HBsAg/anti-HBs immune complexes can be detected by in vitro phagocytosis by PM.
Bromoacetyl—Oxytocin, an Irreversible Inhibitor of Neurohypophyseal Hormone—Stimulated Adenylate Cyclase, and a Possible Affinity Label for Hormone Receptors† (1972)

The synthesis of bromoacetyl—oxytocin, a neurohypophyseal hormone analog containing a chemically reactive group, is described. Bromoacetyl—oxytocin fails to enhance adenylate cyclase activity in particulate membrane preparations of rabbit kidney and toad bladder. Preincubation with this analog inhibits the stimulatory effects of neurohypophyseal hormones upon cyclic 3′,5′–AMP formation in both cyclase preparations; the inhibition is dependent on the duration and temperature of preincubation as well as on the concentration of bromoacetyl—oxytocin. The results of several types of experiments indicate that bromoacetyl—oxytocin acts as a specific irreversible inhibitor of neurohypophyseal hormone action. The findings in this study suggest that this analog, once radioactively labeled, may be useful as an affinity label for the isolation of neurohypophyseal hormone receptor molecules. (Endocrinology91: 39, 1972)
EVALUATION OF STATE-OF-THE-ART MANIPULATORS AND REQUIREMENTS FOR DOE ROBOTICS APPLICATIONS (1998)

This report provides an overview of applications within the DOE complex which could benefit from the use of modular robotics technology during remediation operations. Each application area contains one or more specific tasks which are presently conducted by humans under hazardous conditions or which are deemed highly impractical, or are altogether impossible without automation. Five major areas were investigated for specific needs with respect to automation. Information was collected on Mixed Waste Operations, Contaminant Automated Analysis, Tanks, Decontamination and Dismantlement and Automated Plutonium Processing. During this investigation, information was gathered from available literature, telephone interviews with informed personnel and on-site visits. This data serves to provide design requirements and guidelines for the design of a family of modular actuators, which will be used to construct manipulators suited to each task. In addition, a survey of existing modular manipulator designs is presented. This survey addresses modular manipulators developed inside government labs and in universities for such applications as space exploration or controls research. It also addresses efforts at commercially viable industrial manipulators which have been built. This survey of robotic systems provides the reader with a glimpse into what technology currently exists in the way of modular manipulator automation and, to a degree, where this technology may be applicable or, more often, where these systems are unsuited to EM applications. From the information gathered during this study, it is possible to sufficiently define the requirements of one manipulator system which can be used to conduct automated transfer operations within Plutonium gloveboxes. This manipulator will be constructed from ARM Automation actuator modules and will provide this application with a viable option for automation within these gloveboxes. The design issues surrounding this manipulator and its specifications are discussed in the final portion of this report.
Robust and Direct Route for the Development of Elastomeric Benzoxazine Resins by Copolymerization with Amines (2022)

The development of soft pressure sensors, in particular electronic skin, is fundamental to the interfacing between the human body and the outside world, namely, in prosthetics and biomedical applications. In this context, hybrid composite materials incorporating electrically conducting 2D flakes in an insulating matrix show attractive tunable piezoresistive properties suitable for wide-range pressure sensing applications. Here, we report on the design of novel trifunctional benzoxazine precursors for this polymer matrix based on tris(3-aminopropyl)amine and phenol reagents. These precursors have been successfully synthesized and copolymerized with polyetheramines of different lengths to tune the thermomechanical properties of the resulting networks. Extensive molecular dynamics simulations unambiguously relate the changes in glass transition temperature with chemical composition to the variations in the cross-link density and provide Tg values in excellent agreement with the experimental data. With the longest polyetheramine (2000 g mol–1), we achieve the synthesis of an elastomeric benzoxazine exhibiting remarkably low Tg of −41 °C, a modulus in compression of 50 kPa, and a shear strain modulus of 300 Pa, with high potential for low-pressure sensing applications.