gebhart/patrepeval huggingface dataset:
Financial Business Cloud for High-Frequency Trading A Research on Financial Trading Operations with Cloud Computing (2012)

This paper defines a new business cloud model to create an efficient high-frequency trading platform while validating the portability and also cost-efficiency of cloud execution environments for financial operations. Highfrequency trading systems, built to analyze trends in tick-bytick financial data and thus to inform buying and selling decisions, imply speed and computing power. They also require high availability and scalability of back-end systems which, require high cost investments. The defined model uses cloud computing architecture to fulfill these requirements, boosting availability and scalability while reducing costs and raising profitability. It incorporates data collection, analytics, trading, and risk management modules in the same cloud, all of which, are the main components of a high-frequency trading platform.
Multi-omics and machine learning reveal context-specific gene regulatory activities of PML::RARA in acute promyelocytic leukemia (2023)

The PML::RARA fusion protein is the hallmark driver of Acute Promyelocytic Leukemia (APL) and disrupts retinoic acid signaling, leading to wide-scale gene expression changes and uncontrolled proliferation of myeloid precursor cells. While known to be recruited to binding sites across the genome, its impact on gene regulation and expression is under-explored. Using integrated multi-omics datasets, we characterize the influence of PML::RARA binding on gene expression and regulation in an inducible PML::RARA cell line model and APL patient ex vivo samples. We find that genes whose regulatory elements recruit PML::RARA are not uniformly transcriptionally repressed, as commonly suggested, but also may be upregulated or remain unchanged. We develop a computational machine learning implementation called Regulatory Element Behavior Extraction Learning to deconvolute the complex, local transcription factor binding site environment at PML::RARA bound positions to reveal distinct signatures that modulate how PML::RARA directs the transcriptional response.
Apolipoprotein E*3-Leiden transgenic mice as a test model for hypolipidaemic drugs. (1998)

Apolipoprotein (APO) E*3-Leiden mice with impaired chylomicron and VLDL (very low density lipoprotein) remnant metabolism display hyperlipidaemia and atherosclerosis. In the present study, these mice were used for testing the hypolipidaemic effect of two marketed agents, lovastatin (CAS 75330-75-5) and gemfibrozil (CAS 25812-30-0) as well as a novel compound, SB 204990 (the 5-ring lactone of +/-(3R*,5S*) 3-carboxy-11-(2,4-dichlorophenyl)-3,5-dihydroxyundecanoic acid, CAS 154566-12-8), a potent inhibitor of cholesterol and fatty acid synthesis at the level of ATP-citrate lyase. APOE*3-Leiden mice were fed a saturated fat and cholesterol-rich diet supplemented with either 0.05 or 0.1% w/w of lovastatin, 0.1 or 0.2% w/w of gemfibrozil or 0.1 or 0.2% w/w of SB 204990. Lovastatin showed a dose-related decrease in plasma cholesterol levels (up to -20%) due to a lowering of LDL and HDL (low density resp. high density lipoprotein)-cholesterol (-20 and -18%, respectively), while plasma triglyceride levels were unaffected. Gemfibrozil had no effect on plasma total cholesterol levels but gave significant dose-dependent decreases in plasma (VLDL) triglyceride levels (up to -53%). SB 204990 resulted in a dose-dependent reduction of plasma cholesterol (up to -29%) by lowering VLDL, LDL and HDL-cholesterol (-50, -20 and -20%, respectively). In addition, a strong dose dependent reduction of plasma (VLDL) triglycerides up to -43% was observed with this compound. Although the effects of gemfibrozil and SB 204990 were not simply explained by changes in a single determinant of VLDL metabolism--no effects of these drugs were seen on post-heparin plasma lipoprotein lipase activity, in vivo rate of VLDL synthesis or hepatic apoC-III mRNA levels--APOE*3-Leiden mice were found to give robust hypolipidaemic responses to these test compounds. The responsiveness to hypolipidaemic therapy combined with a clear relationship between aortic lesion size and plasma cholesterol exposure, as demonstrated previously, makes this mouse an attractive model for the testing of anti-atherosclerotic properties of hypolipidaemic drugs.
Figure S1 from Integrative Analysis of Pleomorphic Dermal Sarcomas Reveals Fibroblastic Differentiation and Susceptibility to Immunotherapy (2023)

&lt;p&gt;Figure S1&lt;/p&gt;
CRANIOFACIAL SHORTENING BY CONTRACTION OSTEOGENESIS: AN EXPERIMENTAL MODEL (2000)

Institute of Reconstructive Plastic Surgery NYU Medical Center 560 First Avenue New York, N.Y. 10016
Preface (2006)

This issue of the IBM Journal of Research and Development focuses on exploratory systems. As the name suggests, exploratory systems cover a wide range of cutting-edge technologies that will make future systems better: faster, lower-power, more reliable, more expandable, easier to use, easier to design. The systems in question span a wide range from small embedded devices such as those found in cell phones, washing machines, and animal-tracking collars to installations with thousands of processors and petabytes of storage for handling large databases or for large-scale simulation.
Hypertension control at hospital discharge after acute coronary event: influence on cardiovascular prognosis—the PREVENIR study (2002)

22.1% of patients admitted to hospital for an acute coronary syndrome have uncontrolled isolated systolic hypertension on discharge. This appears to be an independent predictor of cardiovascular outcome.
Intracellular Drug Delivery by Poly(lactic-co-glycolic acid) Nanoparticles, Revisited (2008)

We reexamined the cellular drug delivery mechanism by poly(lactic-co-glycolic acid) nanoparticles (PLGA NPs) to determine their utility and limitations as an intracellular drug delivery system. First, we prepared PLGA NPs which physically encapsulated Nile red (a hydrophobic fluorescent dye), in accordance with the usual procedure for labeling PLGA NPs, incubated them with mesothelial cells, and observed an increase in the intracellular fluorescence. We then prepared NPs from PLGA chemically conjugated to a fluorescent dye and observed their uptake by the mesothelial cells using confocal microscopy. We also used coherent anti-Stokes Raman scattering (CARS) microscopy to image cellular uptake of unlabeled PLGA NPs. Results of this study coherently suggest that PLGA NPs (i) are not readily taken up by cells, but (ii) deliver the payload to cells by extracellular drug release and/or direct drug transfer to contacting cells, which are contrasted with the prevalent view. From this alternative standpoint, we analyzed cytotoxicities of doxorubicin and paclitaxel delivered by PLGA NPs and compared with those of free drugs. Finally, we revisit previous findings in the literature and discuss potential strategies to achieve efficient drug delivery to the target tissues using PLGA NPs.
Efficacy of Malic Acid AgainstCampylobacter jejuniAttached to Chicken Skin During Refrigerated Storage (2015)

The ability of malic acid to reduce Campylobacter jejuni on chicken legs was evaluated. Chicken legs were inoculated with C. jejuni. After dipping legs either in water (control), 1 % or 2% malic acid solution (v/v), they were stored at 4C for 8 days. Changes in C. jejuni, psychrotrophs, Pseudomonas counts and sensorial characteristics (odor, color and overall appearance) were determined after treatment (day 0) and after 1, 3, 6 and 8 days of storage at 4C. Legs washed with 2% malic acid showed a significant (P < 0.05) inhibitory effect on C. jejuni compared to control legs, with a decrease of about 1.18 log units after treatment. The shelf life of the samples washed with malic acid was extended by at least 2 days over the control samples washed with distilled water. This study demonstrates that malic acid is effective for reducing C. jejuni populations on chicken. Practical Applications This study demonstrates that malic acid reduces populations of Campylobacter jejuni on chicken. The application of malic acid cannot replace the rules of strict hygiene and good manufacturing practice, but it may be used as an additional hurdle having important economic implications since it contributes to extend the shelf life of raw chicken, and it has safety implications since it contributes to control pathogens such as Campylobacter jejuni.
Electrical conduction studies on single crystals of transition-metal complexes containing linear chains of directly interacting metal atoms (1971)

Single crystals of [Pt(NH3)4][PtCl4](Magnus's green salt), [Pt(NH3)4][PdCl4], and [Pd(NH3)4][PtCl4] exhibit anisotropic semiconducting properties with the highest conductivity in the direction of the metal-atom chain. The conductivities of the complexes which contain alternate Pd and Pt atoms are 104 times less than that of Magnus's green salt. Conduction studies in the direction of the metal-atom chain are also reported for single crystals of Ni(dmg)2, Pd(dmg)2 and some related compounds, and the conductivities in the two types of complexes are compared.
Three dimensional alignment of magnetic particles (1997)

In this article, novel magnetic particle alignment methods, which we refer to as dynamic alignment, are presented. In the process of a dynamic alignment, the magnetic field direction is periodically changed while the particle orientation is captured in epoxy resin. Depending on the manner of the variation of the magnetic field, particles can be aligned in various patterns. By employing the dynamic alignment methods described in this article, the alignment of magnetic particles can be achieved such that particles are aligned along all three crystalline axes.
A Double-Private epsilon-Fuzzy Matching Protocol (2015)

This paper proposes a new double-private protocol for fuzzy matching and c-fuzzy matching. Many works have been done for private database search in which the keyword that a user inputs for the search is concealed to the database owner. In these database searches, the exactly matched data are returned to the user. Fuzzy matching has been proposed in which not exactly matched but nearly matched data are returned to the user. Then the condition to be matched is further relaxed by c-fuzzy matching. In fuzzy matching and c-fuzzy matching, a new security requirement, the security of the database can be considered. The database owner just answers the existence of a matched data without showing the matched data itself. This paper first formalizes the problem as the double-private c-fuzzy matching. We show a naive protocol and an efficient protocol for double-private c-fuzzy matching.
Embedded memory test and repair: infrastructure IP for SOC yield (2003)

Today's system-on-chip typically embeds memory IP cores with very large aggregate bit count per SoC. This trend requires using dedicated resources to increase memory yield, while containing test and repair cost and minimizing time-to-volume. This paper summarizes the evolution of such yield optimization resources, compares their trade-offs, and concentrates on on-chip infrastructure IP. To maximize the repair efficiency, this infrastructure IP needs to leverage the memory design knowledge and the process failure data. The ideal solution is to integrate the memory IP and its infrastructure IP into a single composite IP that yields itself effectively.
Four-point optical energy distributions for faint BL Lacertae objects (1976)

Broad-band photoelectric observations of 10 radio sources with continuous optical spectra have been reduced to monochromatic flux densities in order to study the shape and variations of their optical energy distributions. The observed spectral indices range between 1 and 3. It is suggested that sources with a large optical spectral index may have detectable nebulosity.
Enzalutamide for treatment of CRPC: Rationale for sequencing and potential clinical biomarker for resistance (2015)

The androgen receptor (AR) is central to the initiation and progression of prostate cancer, even after castration. There has been some success in therapies targeting AR signaling which have been shown to extend survival in men with castration-resistant prostate cancer (CRPC). Enzalutamide is a potent AR antagonist that was initially approved in 2012 for men with CRPC who had previously failed chemotherapy treatment with docetaxel. Herein, we reviewed 2 key manuscripts that have recently appeared in the New England Journal of Medicine regarding enzalutamide. The PREVAIL Phase 3 trial was designed to evaluate enzalutamide before chemotherapy in men with CRPC. The study illustrated that 65% of patients receiving enzalutamide had radiographic-progression free survival. There was a significant risk reduction of radiographic progression or death, compared with the placebo group. The enzalutamide group's median overall survival was 32.4 months vs. 30.2 months in the placebo group.
Minimizing data and synchronization costs in one-way communication (2002)

In contrast to the conventional send/receive model, the one-way communication model using Put and Synch allows the decoupling of message transmission from synchronization. This opens up new opportunities not only to further optimize communication but also to reduce synchronization overhead. We present a general technique which uses a global dataflow framework to optimize communication and synchronization in the context of the one-way communication model. Our approach works with the most general data alignments and distributions in languages like HPF, and is more powerful than other current solutions for eliminating redundant synchronization messages. Preliminary results on several scientific benchmarks demonstrate that our approach is successful in minimizing the number of data and synchronization messages.
A New Laboratory Apparatus for Use in the Chemical Modification of Packaged Cellutosic Yarns (1965)

A new apparatus for the chemical reaction of cotton and other cellulosic yarns with organic reagents at elevated temperatures has been constructed and tested. The device, made entirely' of chemically resistant materials, supports a loosely wound yarn package while reagents are pumped through it. A key feature of the apparatus is a special Tefion tube which supports the yarn and which can contract substantially during the reaction. The tube allows for contraction of the yarn, better permeability of reagents, and uni formity of substitution. Use of the apparatus yields yarn that is in a form suitable for textile evaluation.
SA1 (2007)

This tutorial assumes no previous knowledge or experience with the Ada programming language.Ada was originally designed in around 1980. Important goals included: to provide a portable and uniform language to replace a number of existing languages then in use; to capture the state of the art in language design; to recognize that programming was a serious engineering discipline; and to be highly reliable and encourage the development of long lived and maintainable programs.However, Ada 83 (as the first version was known) was developed before the ideas of OOP matured and tasking was fully understood. Accordingly Ada was enhanced in 1995 to cover these topics and others. In this tutorial John will introduce the main themes of Ada and hopefully show why it is an excellent language for systems that need to be reliable and to be maintained.
Performance improvement algorithms for colour image compression using DWT and multilevel block truncation coding (2010)

This paper introduces two algorithms for colour image compression. The first one is intensity based adaptive quantization coding (IBAQC), while the second is a combination of discrete wavelet transforms (DWT) and the IBAQC algorithm. The AQC produced a good peak signal to noise ratio (PSNR) with high bit per pixels (bpp). The aim of this paper is to present algorithms with low bit rate whilst preserving the PSNR and image quality to an acceptable range. The experiments were performed using different kinds of standard color images, multi level quantizers, different thresholds, different block sizes, and different wavelet filters. Both algorithms considered the intensity variation of each colour plane. The results obtained showed a good reduction in bpp compared with the AQC algorithm, with a little loss in PSNR due to the dropping of some blocks that claimed to be low intensity variation according to a comparison with predefined thresholds for each colour plane.
Ate Complexes of Secondary Boronic Esters as Chiral Organometallic-Type Nucleophiles for Asymmetric Synthesis (2011)

The addition of an aryllithium reagent to a secondary boronic ester leads to an intermediate boron-ate complex that behaves as a chiral nucleophile, reacting with a broad range of electrophiles with inversion of stereochemistry. Depending on the electrophile, the C-B bond can be converted into C-I, C-Br, C-Cl, C-N, C-O, and C-C, all with very high levels of stereocontrol. This discovery now adds a new, readily available, configurationally stable, chiral organometallic-type reagent to the arsenal of methods for use in asymmetric organic synthesis.
Field Analysis of AIS1 Neck Injuries in Rear-End Car Impacts (2004)

AbstractIntroduction. AIS1 neck injuries are the most common type of injury resulting from rear-end impacts. In 1998, Whiplash Protection System (WHIPS) was introduced in Volvo cars, comprising of an energy absorbing recliner mechanism for the front seats.Method. Since 1999, rear-end impacts of Volvo cars in Sweden have been investigated on a regular basis, including one-year post accident follow-up. A total of 1,608 front seat occupants (above 14 years of age) have been analyzed regarding influencing factors on incidence of AIS1 neck injuries. The AIS1 neck injury reducing effect of WHIPS was calculated from a subset of 324 front seat occupants who had no prior neck problems and who had undergone a moderate severity rear end impact. Occupants in cars equipped with WHIPS are compared to those in Volvo cars of model year 1999 without WHIPS.Results and Conclusions. Prior neck problems are a significant influential factor and should be taken into consideration. Sitting posture, such as turned head and increased head to head restraint distance significantly increases AIS1 neck injury rates. For the selection made in this study, the injury-reducing effect of WHIPS as compared to previous Volvo seats is 33% (p = 0.002) for initial neck symptoms and 53% (p = 0.01) for neck symptoms lasting longer than one year. The injury reducing effect is higher for women than for men.Key Words: WHIPSAIS1 neck injuriesrear-end impactwhiplash
<title>Characterization of strained-Si/SiGe/Si heterostructures with capacitance methods</title> (2006)

The DLTS and admittance measurements were performed on the MOS and Schottky diodes formed on the strained-Si/SiGe/Si heterostructures. Several DLTS features were observed and analyzed, and properties of the peculiar Dl peak were studied in detail. Temperature dependence of the SiGe layer conductivity was extracted from the C(T) and G(T) curves. The analysis of ability of the DLTS technique to detect defects in the thin top layer is given.
Determining pose of 3D objects with curved surfaces (1996)

A method is presented for computing the pose of rigid 3D objects with arbitrary curved surfaces. Given an input image and a candidate object model and aspect, the method will verify whether or not the object is present and if so, report pose parameters. The curvature method of Bash and Ullman is used to model points on the object rim, while stereo matching is used for internal edge points. The model allows an object edge-map to be predicted from pose parameters. Pose is computed via an iterative search for the best pose parameters. Heuristics are used so that matching can succeed in the presence of occlusion and artifact and without resetting to use of corresponding salient feature points. Bench tests and simulations show that the method almost always converges to ground truth pose parameters for a variety of objects and for a broad set of starting parameters in the same aspect.
PAPPA-mediated adipose tissue remodeling mitigates insulin resistance and protects against gestational diabetes in mice and humans (2020)

Pregnancy is a physiological state of continuous adaptation to changing maternal and fetal nutritional needs, including a reduction of maternal insulin sensitivity allowing for appropriately enhanced glucose availability to the fetus. However, excessive insulin resistance in conjunction with insufficient insulin secretion results in gestational diabetes mellitus (GDM), greatly increasing the risk for pregnancy complications and predisposing both mothers and offspring to future metabolic disease. Here, we report a signaling pathway connecting pregnancy-associated plasma protein A (PAPPA) with adipose tissue expansion in pregnancy. Adipose tissue plays a central role in the regulation of insulin sensitivity, and we show that, in both mice and humans, pregnancy caused remodeling of adipose tissue evidenced by altered adipocyte size, vascularization, and in vitro expansion capacity. PAPPA is known to be a metalloprotease secreted by human placenta that modulates insulin-like growth factor (IGF) bioavailability through prolteolysis of IGF binding proteins (IGFBPs) 2, 4, and 5. We demonstrate that recombinant PAPPA can stimulate ex vivo human adipose tissue expansion in an IGFBP-5- and IGF-1-dependent manner. Moreover, mice lacking PAPPA displayed impaired adipose tissue remodeling, pregnancy-induced insulin resistance, and hepatic steatosis, recapitulating multiple aspects of human GDM. In a cohort of 6361 pregnant women, concentrations of circulating PAPPA are inversely correlated with glycemia and odds of developing GDM. These data identify PAPPA and the IGF signaling pathway as necessary for the regulation of maternal adipose tissue physiology and systemic glucose homeostasis, with consequences for long-term metabolic risk and potential for therapeutic use.
<title>Copper-pumped dye laser system at Lawrence Livermore National Laboratory</title> (1993)

The Lawrence Livermore National Laboratory's (LLNL) Atomic Vapor Laser Isotope Separation (AVLIS) Program has developed a high-average-power, pulsed, tunable, visible laser system. Testing of this hardware is in progress at industrial scales. The LLNL copper- dye laser system is prototypical of a basic module of a uranium-AVLIS plant. The laser demonstration facility (LDF) system consists of copper vapor lasers arranged in oscillator- amplifier chains providing optical pump power to dye-laser master-oscillator-power-amplifier chains. This system is capable of thousands of watts (average) tunable between 550 and 650 mm.
Calculating Q of complex small antennas using FDTD method (2006)

In this paper, we propose a numerical procedure to study the radiation quality factor of arbitrary and complex antennas. Based on the Finite Difference method in Time Domain (FDTD), the procedure produces very accurate value for antenna Q. Employed as reference results, these values will then be compared to those obtained by several analytical approaches based on the antenna input impedance. To conclude, we present the drawbacks and advantages of the numerical and analytical approaches.