gebhart/patrepeval huggingface dataset:
Accelerated radiotherapy regimen for malignant gliomas using stereotactic concomitant boosts for dose escalation (1998)

The purpose of this pilot study was to determine the feasibility and toxicities of an accelerated treatment program by using a concomitant stereotactic radiotherapy boost given weekly during a course of standard external-beam irradiation (EBXRT) in patients with malignant gliomas. Twelve patients underwent biopsy or subtotal resection of a malignant glioma and were enrolled on the protocol, which delivered 44 Gy-EBXRT and a 12-Gy stereotactic radiotherapy boost given on 3 consecutive weeks of treatment for a total dose of 80 Gy over 33 days. Three patients with anaplastic astrocytoma and nine patients with glioblastoma multiforme had median survival times of 33 months and 16 months, respectively. All of the tumor recurrences were within or were closely adjacent to the region of high-dose irradiation. None of the patients required a treatment break, and there were no acute complications. Two patients developed seizures in the follow-up period, and four patients were diagnosed with radionecrosis at the time of the second operation. The treatment program was found to be feasible and was well tolerated, and it resulted in a rate of late complications similar to those of radiosurgery or interstitial brachytherapy.
C–C bond cleavage reactions of episulphones. A convenient new synthesis of thiepin 1,1-dioxide (1971)

The reaction of vinyldiazomethane and its derivatives with sulphur dioxide and sulphenes yields dihydrothiepin 1,1-dioxide which are useful precursors to thiepin 1,1-dioxides; the probable intermediacy of divinyl episulphones in these reaction is discussed.
Changes in glucose disposal after a caloric restriction–induced weight loss program in obese postmenopausal women (2014)

An important interindividual variability in changes in glucose disposal after weight loss is observed. Interestingly, participants who display improvements in glucose disposal also show significant decreases in LBM, LBM index, and hsCRP after weight loss.
Discrimination of water from shadow regions on radar imagery using computer vision techniques (1985)

Unlike MSS LANDSAT imagery and other photography, the specific characteristics of the intensity of water and shadow reflectivity in SAR imagery make the task of discriminating between them extremely difficult. In this report, we analyze the mechanism of reflectivity of water and shadow on radar imagery and describe a scene-analysis system which consists of a texture-preserving noise-removal procedure as the preprocessing step, a probabilistic relaxation algorithm to do the low-level labeling, and a spatial reasoning procedure based on a relational model to perform the high-level interpretation. The experimental results obtained from the SAR images are presented to illustrate the performance of this system. Keywords include: MTA filter; Noise removal; Radar interpretation; SAR imagery; Scene analysis; and Texture preserving.
When new science meets old traditions (2017)

This chapter compares responses to the global voluntary male medical circumcision (VMMC) initiative in two small southern African countries Lesotho and Swaziland. These two countries are particularly instructive, as their realities contradict the evidence upon which global VMMC policy was established both countries have heavy HIV burdens but contrasting male circumcision (MC) practices. In the US and the UK, MC fell out of favor given limited scientific evidence of its value. Despite a strong opposition movement in the 1960s, MC was re-medicalized in the US as a common procedure in neonates. An initial rapid assessment and cost-effectiveness analysis was conducted in 2007 in Lesotho, following the World Health Organization (WHO) endorsement of VMMC, with a full situational analysis completed in 2008. The case of VMMC as a new HIV prevention strategy presents itself as a global endeavor an interconnectedness of ideas, interpretations, and reflexivity across national borders and geographical and ideological boundaries.
Localization, Shedding, Regulation and Function of Aminopeptidase N/CD13 on Fibroblast like Synoviocytes (2016)

Aminopeptidase N/CD13 is highly expressed by fibroblast like synoviocytes (FLS) and may play a role in rheumatoid arthritis (RA). CD13 was previously detected in human synovial fluid where it was significantly increased in RA compared to osteoarthritis. In this study we found that CD13 in biological fluids (plasma, synovial fluid, FLS culture supernatant) is present as both a soluble molecule and on extracellular vesicles, including exosomes, as assessed by differential ultracentrifugation and density gradient separation. Having determined CD13 could be released as a soluble molecule from FLS, we examined potential mechanisms by which CD13 might be shed from the FLS membrane. The use of protease inhibitors revealed that CD13 is cleaved from the FLS surface by metalloproteinases. siRNA treatment of FLS revealed one of those proteases to be MMP14. We determined that pro-inflammatory cytokines (TNFα, IFNγ, IL-17) upregulated CD13 mRNA in FLS, which may contribute to the increased CD13 in RA synovium and synovial fluid. Inhibition of CD13 function by either inhibitors of enzymatic activity or anti-CD13 antibodies resulted in decreased growth and diminished migration of FLS. This suggests that CD13 may be involved in the pathogenic hyperplasia of RA FLS. This data expands potential roles for CD13 in the pathogenesis of RA.
A Fast Impedance Tuner Implementation in a Cognitive Radar for Synchronous Real-Time Optimization in a Congested Environment (2022)

As S-Band frequencies continue to be reallocated for sharing with wireless communications, radar systems are forced to operate in a spectrum that is becoming increasingly congested and contested. Based on other spectrum users, cognitive radar systems must quickly react, change operating frequency, and reconfigure for best performance to share successfully. A real-time impedance tuner is implemented within a software-defined radar (SDRadar) system demonstrated here for maximizing transmitter output power (and transmission range) in real time when changing frequencies to share spectrum. The SDRadar and reconfigurable impedance tuner are shown to achieve up to 46 percent improvement in range, with synchronous reconfiguration accomplished in less than 10 ms. Considering recent and parallel developments in high-power, quickly reconfigurable impedance tuners, it is becoming apparent that power handling, speed, and performance improvements are expected to revolutionize adaptive radar transmission.
Fuels and Lubricants Handbook: Technology, Properties, Performance, and Testing (2003)

Manual 37 is a comprehensive, in-depth, well-referenced handbook that provides a detailed overview of ALL of the important ASTM and non-ASTM fuels and lubricants test procedures. Readers will get a thorough overview of the application-related properties
A novel technique for run-time loading for MIPS soft-core processor (2013)

Soft-core processors on Field Programmable Gate Array (FPGA) chips are becoming an increasingly popular solution to support application-specific customization. However, any change in the assembly code of the implemented processor requires re-implement and download the soft-core on FPGA. This paper presents a FPGA realization of a run-time loading technique for a 32-bit MIPS (Microprocessor without Interlocked Pipeline Stages) processor. The update of MIPS code is done without having to resynthesize, place and route, and reload the soft-core. The design consists of three main blocks: a microprocessor soft-core, a software tool and a universal asynchronous receiver/transmitter (UART). The software tools sets the content of the instruction memory space of the processor without having to go through the FPGA implementation process. The FPGA implements MIPS soft-core processor as well as the UART receiver. The software tool communicates with the softcore via UART. To demonstrate the proposed technique, we wrote an UP/DOWN counter assembly code. The design architecture is coded using Verilog based on top-down hierarchical design methodology and realized in Spartan-3E FPGA using Xilinx ISE 14.2. Based on the FPGA implementation results, the maximum operating frequency of the CPU is found to be 43.17 MHz.
Copper(I)-Catalyzed Coupling of Terminal Acetylenes with Aryl or Vinyl Halides (2005)

Synthetic protocols using copper(I) catalysts for the formation of diaryl acetylenes, 1,3-enynes, benzofurans and indoles are described.
Hereditary Motor and Sensory Neuropathy (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Ureteral stricture formation in laparoscopically procured living donor kidney transplantation. (2012)

Delayed graft function and nonuse of ureteral stents are associated with the development of ureteral strictures following LLDKT.
Human STX Polysialyltransferase Forms the Embryonic Form of the Neural Cell Adhesion Molecule (1997)

PST and STX are polysialyltransferases that form polysialic acid in the neural cell adhesion molecule (N-CAM), although it is not known why these two polysialyltransferases exist. In the present study, we have first isolated cDNA encoding human STX, which includes 5'-untranslated sequence. Northern blot analysis, using this cDNA and PST cDNA previously isolated by us, demonstrated that PST and STX are expressed in different fetal and adult tissues. STX is primarily expressed in embryonic tissues, but only modestly in adult heart, brain, and thymus. PST, on the other hand, is continuously expressed in adult heart, brain, thymus, spleen, small and large intestines, and peripheral blood leukocytes. In various parts of adult brain, the relative amount of PST and STX appears to be substantially different depending on the regions. The analysis by in situ hybridization of mouse adult brain, however, suggests that polysialic acid in the hippocampal formation is synthesized by both STX and PST. HeLa cells doubly transfected with the isolated STX cDNA and N-CAM cDNA supported neurite outgrowth much better than HeLa cells expressing N-CAM alone. However, polysialic acid synthesized by PST appears to be a better substratum than that synthesized by STX. Moreover, the genes for PST and STX were found to reside at chromosome 5, band p21 and chromosome 15, band q26, respectively. These results, taken together, strongly suggest that PST and STX are expressed distinctly in tissue-specific and cell-specific manners and that they apparently have distinct roles in development and organogenesis.
A real-time traffic monitoring system by stochastic model combination (2004)

In order to model and to control traffics efficiently, precise traffic monitoring is very important. For those purposes, we developed a real-time system which is able to detect various events such as accidents, congestion, stalled vehicles, fallen objects, etc., and also able to record images before and after the events. This system is based on dedicated tracking algorithm called the spatio-temporal MRF model, which is very robust against occlusions and variations in illumination. Combined with stochastic reasoning, our system was able to classify above events against cluttered situations in traffic images. Finally, by operating the system by a roadside for six months, our system proven to be very successful.
Familial hypothyroidism caused by a nonsense mutation in the thyroid-stimulating hormone beta-subunit gene. (1990)

Hereditary hypothyroidism caused by thyroid-stimulating hormone (TSH) deficiency is a rare autosomal recessive disease. Affected individuals show symptoms of severe mental and growth retardation that can be prevented by early administration of exogenous thyroid hormone. In this paper, we describe two related Greek families with three children affected by congenital TSH-deficient hypothyroidism. Sequence analysis of the TSH beta-subunit gene (TSHB) showed that the mutation responsible for the hypothyroidism in these families is a nonsense mutation in exon 2. This mutation is a G-to-T transversion at nucleotide 94 that destroys the only TaqI site in the TSHB-coding region and gives rise to a novel 8.5-kb TaqI fragment. Restriction analysis showed that the three affected children are homozygous for the 8.5-kb allele and that the four parents and two unaffected children are heterozygous. This mutation gives rise to a truncated peptide which includes only the first 11 of 118 amino acids of the mature TSHB peptide.
A Multiple-Reflection Optical Lever (1949)

A detailed description is given of the principles of an optical lever which secures increased sensitivity by means of multiple reflections from a single small mirror. It is of particular use where space is limited, or where the mirror must have minimum size and mass, as in a galvanometer. Its limitations are an inherent restriction of the measurable range, and a comparatively rapid loss of light with increasing number of reflections. A model system was constructed, which demonstrates that no special difficulty is met with in making an optical lever according to these principles up to seven reflections. Tests made with the fifth-order reflection proved the model to be quite satisfactory.
Photochromic Benzo[b]phosphole Alkynylgold(I) Complexes with Mechanochromic Property to Serve as Multistimuli‐Responsive Materials (2018)

A series of novel benzo[b]phosphole alkynylgold(I) complexes has been demonstrated to display photochromic and mechanochromic properties upon applying the respective stimuli of light and mechanical force. Promising multistimuli-responsive properties of this series of gold(I) complexes have been successfully achieved through judicious molecular design, which involves incorporation of the photochromic dithienylethene-containing benzo[b]phosphole into the triphenylamine-containing arylethynyl ligand that is susceptible to mechanical force-induced color changes via gold(I) complexation. With excellent thermal irreversibility and robust fatigue resistance of this series of gold(I) complexes, multicolor states controlled by the photochromism and mechanochromism have been realized. Repeatable photochromic and mechanochromic cycles without apparent loss of reactivity have also been observed under ambient conditions. The present work provides important insight and an alternative strategy for the molecular design of multistimuli-responsive materials, paving the way for further development of the underexplored photoresponsive gold(I) complexes and the multistate photocontrolled system.
A wideband linear‐in‐dB VGA using a CMOS in the triode region (2006)

Abstract This paper presents a wideband variable gain amplifier (VGA) fabricated using the 0.18‐μm CMOS process. An exponential CMOS triode transconductor scheme is proposed to achieve highly linear‐in‐dB characteristics of a VGA for ultra‐wideband (UWB) systems. The proposed VGA achieves a linear‐in‐dB controllable gain range of 28.4 dB (7 to −21.4 dB) with a bandwidth of 1200 MHz, while drawing only 2.7 mA from a 1.8‐V power supply. Measurements show a linear gain range with a linearity error of less than ±0.5 dB. P 1dB varies from −8.5 to −6 dBm. The chip occupies an area of 0.2 × 0.2 mm 2 , excluding bond‐pads. © 2006 Wiley Periodicals, Inc. Microwave Opt Technol Lett 48: 997–1000, 2006; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.21546
Blue Emitters Based on Aryl End-Capped Pyrene Groups for OLEDs (2016)

We have synthesized four pyrene-derived blue emitting materials using Suzuki cross coupling reactions. All OLED devices using these materials as emitting materials showed efficient blue electroluminescence (EL). Particularly, a device using 1,1'-(9,9-dimethyl-9H-fluorene-2,7-diyl)bis-pyrene (1) showed best EL properties with the luminous efficiency of 4.32 cd/A, the power efficiency of 3.98 lm/W and the external quantum efficiency of 2.48% at 500 cd/m2.
Detection of SSH Brute Force Attacks Using Aggregated Netflow Data (2015)

The SSH Brute force attack is one of the most prevalent attacks in computer networks. These attacks aim to gain ineligible access to users' accounts by trying plenty of different password combinations. The detection of this type of attack at the network level can overcome the scalability issue of host-based detection methods. In this paper, we provide a machine learning approach for the detection of SSH brute force attacks at the network level. Since extracting discriminative features for any machine learning task is a fundamental step, we explain the process of extracting discriminative features for the detection of brute force attacks. We incorporate domain knowledge about SSH brute force attacks as well as the analysis of a representative collection of the data to define the features. We collected real SSH traffic from a campus network. We also generated some failed login data that a legitimate user who has forgotten his/her password can produce as normal traffic that can be similar to the SSH brute force attack traffic. Our inspection on the collected brute force Netflow data and the manually produced SSH failed login data showed that the Netflow features are not discriminative enough to discern brute force traffic from the failed login traffic produced by a legitimate user. We introduced an aggregation of Netflows to extract the proper features for building machine learning models. Our results show that the models built upon these features provide excellent performances for the detection of brute force attacks.
Expression of protein-tyrosine phosphatases in Acute Myeloid Leukemia cells: FLT3 ITD sustains high levels of DUSP6 expression (2012)

Protein-tyrosine phosphatases (PTPs) are important regulators of cellular signaling and changes in PTP activity can contribute to cell transformation. Little is known about the role of PTPs in Acute Myeloid Leukemia (AML). The aim of this study was therefore to establish a PTP expression profile in AML cells and to explore the possible role of FLT3 ITD (Fms-like tyrosine kinase 3 with internal tandem duplication), an important oncoprotein in AML for PTP gene expression. PTP mRNA expression was analyzed in AML cells from patients and in cell lines using a RT-qPCR platform for detection of transcripts of 92 PTP genes. PTP mRNA expression was also analyzed based on a public microarray data set for AML patients. Highly expressed PTPs in AML belong to all PTP subfamilies. Very abundantly expressed PTP genes include PTPRC, PTPN2, PTPN6, PTPN22, DUSP1, DUSP6, DUSP10, PTP4A1, PTP4A2, PTEN, and ACP1. PTP expression was further correlated with the presence of FLT3 ITD, focusing on a set of highly expressed dual-specificity phosphatases (DUSPs). Elevated expression of DUSP6 in patients harboring FLT3 ITD was detected in this analysis. The mechanism and functional role of FLT3 ITD-mediated upregulation of DUSP6 was then explored using pharmacological inhibitors of FLT3 ITD signal transduction and si/shRNA technology in human and murine cell lines. High DUSP6 expression was causally associated with the presence of FLT3 ITD and dependent on FLT3 ITD kinase activity and ERK signaling. DUSP6 depletion moderately increased ERK1/2 activity but attenuated FLT3 ITD-dependent cell proliferation of 32D cells. In conclusion, DUSP6 may play a contributing role to FLT3 ITD-mediated cell transformation.
Distributed Systems to Support Efficient Adaptation for Ubiquitous Web (2005)

The ubiquitous Web will require many adaptation and personalization services which will be consumed by an impressive amount of different devices and classes of users. These novel advanced services will stress the content provider platforms in an unprecedented way with respect to the content delivery seen in the last decade. Most services such as multimedia content manipulation (images, audio and video clips) are computationally expensive and no single server will be able to provide all of them, hence scalable distributed architectures will be the common basis for the delivery platform. Moreover these platforms would even address novel content management issues that are related to the replication and to the consistency and privacy requirements of user/client information. In this paper we propose two scalable distributed architectures that are based on a two-level topology. We investigate the pros and cons of such architectures from both a security, consistency and performance points of view.
Direct Asymmetric Aldol Reaction of 5H-Oxazol-4-ones with Aldehydes Catalyzed by Chiral Guanidines (2010)

A new chiral bicyclic guanidine-catalyzed direct catalytic aldol reaction of 5H-oxazol-4-ones with aldehydes has been developed. The present aldol reaction proceeds smoothly with high enantioselectivity using bicyclic guanidines bearing a hydroxy group at the appropriate position, and various combinations of 5H-oxazol-4-ones and aldehydes are applicable. The method provides synthetically useful alpha,beta-dihydroxycarboxylates bearing a chiral quaternary stereogenic center at the alpha-carbon atom.
Sixth International Congress on Shwachman‐Diamond syndrome: from patients to genes and back (2011)

At the Sixth International Congress on Shwachman-Diamond syndrome, held at the New York Academy of Sciences on June 28-30, 2011, researchers from around the world met to discuss the latest clinical and basic science relating to this puzzling condition.