gebhart/patrepeval huggingface dataset:
Comparative Transcriptional Profiling of the Axolotl Limb Identifies a Tripartite Regeneration-Specific Gene Program (2013)

Understanding how the limb blastema is established after the initial wound healing response is an important aspect of regeneration research. Here we performed parallel expression profile time courses of healing lateral wounds versus amputated limbs in axolotl. This comparison between wound healing and regeneration allowed us to identify amputation-specific genes. By clustering the expression profiles of these samples, we could detect three distinguishable phases of gene expression - early wound healing followed by a transition-phase leading to establishment of the limb development program, which correspond to the three phases of limb regeneration that had been defined by morphological criteria. By focusing on the transition-phase, we identified 93 strictly amputation-associated genes many of which are implicated in oxidative-stress response, chromatin modification, epithelial development or limb development. We further classified the genes based on whether they were or were not significantly expressed in the developing limb bud. The specific localization of 53 selected candidates within the blastema was investigated by in situ hybridization. In summary, we identified a set of genes that are expressed specifically during regeneration and are therefore, likely candidates for the regulation of blastema formation.
Effects of Silverleaf Whiteflies on Sticky Cotton and Cotton Yields in Arizona (1996)

Silverleaf whitey, Bemisia argentifolii Bellows and Perring, adults and nymphs were significantly reduced season -long in cotton plots treated with fenpropathrin plus acephate on 3 occasions (15 July, 2 August and 29 August). Thermodetector sticky cotton ratings were significantly reduced in insecticide-treated plots compared with untreated plots. Heavy rains reduced cotton stickiness in all plots.
Optimization of Culture Conditions for The Probiotic Bacterium Pediococcus Pentosaceus using a Factorial Design (2019)

Pediococcus pentosaceus is a probiotic-bacterium able to confer a health benefit on the host because this bacterium can prevent the pathogen adhesion to intestinal cells as well as could tolerate bile salts, gastric and intestinal conditions. In particular, there are evidence that P. pentosaceus attenuates the severity of colitis and improve the intestinal permeability. By this reason is important stablishing the adequate conditions for the growth of probioticbacterium P. pentosaceus. The aim of the present study was evaluated the effect of temperature in shaken flasks, as well as the effect of pH and stirring speed on the growth and cell viability of P. pentosaceus using a 2 2 factorial design. We found that in the range of 34 to 40C, the temperature affected the specific growth rate, biomass production and cell viability of probiotic-bacterium P. pentosaceus, being 37C the optimum temperature condition for the culture of the bacterium. In bioreactor cultures, we observed that the stirring speed and pH not affected the biomass production and cell viability. The specific growth rate only was affected by the pH and we obtained the equation: = 0.95 + 0.064 pH with an R-squared value of 0.964. These findings allow establishing the conditions of suitable cultures to advantage the growth of probiotic-bacterium P. pentosaceus increasing biomass production and their cell viability.
Pretreatment and Fractionation of Wheat Straw with Acetic Acid to Enhance Enzymatic Hydrolysis and Ethanol Fermentation (2011)

Abstract Acetic acid was used to pretreat and fractionate wheat straw. A 25% acetic acid solution at 160°C could remove all xylan and 26.2% of lignin in the wheat straw at a 10% solid concentration while recovering 94.2% of glucan. The glucan content of the pretreated wheat straw was 60.9% compared to 35.5% in the raw wheat straw. After the 6-day hydrolysis with a cellulase at a load of 15 FPU/g glucan, 67.6% of the glucan in the acetic acid-pretreated wheat straw was hydrolyzed into glucose, compared to 58.3, 26.0, and 24.4% for pure cellulose, wheat straw pretreated with hot water at 160°C, and raw wheat straw, respectively.
Detection of multiple, partially occluded humans in a single image by Bayesian combination of edgelet part detectors (2005)

This paper proposes a method for human detection in crowded scene from static images. An individual human is modeled as an assembly of natural body parts. We introduce edgelet features, which are a new type of silhouette oriented features. Part detectors, based on these features, are learned by a boosting method. Responses of part detectors are combined to form a joint likelihood model that includes cases of multiple, possibly inter-occluded humans. The human detection problem is formulated as maximum a posteriori (MAP) estimation. We show results on a commonly used previous dataset as well as new data sets that could not be processed by earlier methods.
XML-Signature Syntax and Processing (2001)

Language) digital signature processing rules and syntax.XML Signatures provide integrity, message authentication, and/or signer authentication services for data of any type, whether located within the XML that includes the signature or elsewhere.
Dynamics of Surfactant Self-Assemblies (2005)

Dynamics of Surfactant Self-Assemblies explains the dynamics of micellar equilibria, tracking surfactant exchange, and micelle formation/breakdown processes. Highlighting the structural similarities of amphiphilic block copolymers to surfactants, this volume elucidates the dynamics of more complex self-assemblies that surfactants and amphiphilic bl
Investigation of cascadability and optimum inter-regenerator spacing in transmission with all-optical 3R regeneration (2005)

Transmission with cascaded all-optical 3R regeneration is reported using a reconfigurable fibre loop to investigate, for the first time, the impact of varying the inter-regenerator spacing on long distance transmission. Error-free transmission at 10 Gb/s over 20000 km of standard single-mode fibre was achieved with inter-regenerator spacing range of 150-600 km, corresponding to an OSNR range of 30-23 dB/0.1 nm at the regenerator input
Catalytic removal of propene in air over Pd oxide catalysts (2008)

international
High Temperature Superconductivity Arising in a Metal Sheet Full of Holes (2022)

By drilling periodic thru-holes in a suspended film, the phonon system can be modified. Being motivated by the BCS theory, the technique, so-called phonon engineering, was applied to a niobium sheet. The newly emergent high-Tc superconductivity, however, cannot be accounted for by the BCS theory. Rather, its exposed configuration, namely a square-lattice oxygen network, is reminiscent of the copper--oxygen plane in cuprate high-Tc superconductors. It turns out that its magnetic result is consistent with the principle of giant atom, which was developed by another heroes of superconductivity, Fritz London and John Slater, in the 1930s, several decades earlier than the propagation of BCS theory. The superconducting transition feature is discussed on the basis of a comprehensive theory of the giant atom---the theory of hole superconductivity.
[ASBMR 2009 Report. Meeting report on the ASBMR. ASBMR topics]. (2010)

This is a meeting report on the ASBMR which was held from September 11th to 15th 2009 in Colorado, Denver. In this report, we focus on recent advances in understanding the roles of Wnt signaling in the regulation of bone metabolism.
Purification and properties ofThermus filiformisDNA polymerase expressed inEscherichia coli (1999)

The gene encoding Thermus filiformis (Tfi) DNA polymerase was expressed under the control of the tac promoter on a high-copy plasmid, pJR, in Escherichia coli. The Tfi DNA polymerase was purified by using heat treatment and DEAE-Sephacel column chromatography. The purified enzyme had a molecular mass of 92 kDa, as estimated by SDS/PAGE. The optimum pH and temperature of the enzyme were 8.4-9.0 and 70-72.5 degrees C respectively. The half-life of the enzyme at 94 degrees C was approx. 40 min. The enzyme was activated by the bivalent cations, Mg(2+) and Mn(2+), and was inhibited by EDTA. The optimal Mg(2+) concentration of the enzyme was 4 mM. The optimal conditions for the PCR reaction were slightly different from those for the enzyme activity except for the optimal Mg(2+) concentration. Low concentrations of KCl had no effect on either the enzymic activity or the PCR amplification. The result of the PCR experiment with the enzyme indicates that Tfi DNA polymerase might be useful in DNA amplification.
Analysis of succinylacetone, as a Girard T derivative, in urine and dried bloodspots by flow injection electrospray ionization tandem mass spectrometry (2006)

Flow injection electrospray ionization tandem mass spectrometric methods for succinylacetone (SA) in 250 microL urine, using d5-SA as internal standard, and in 3 mm dried bloodspots, using 13C4-SA as internal standard, are described. Selectivity and sensitivity of analysis is achieved by the use of a mono-Girard T derivative. Measured SA infant urine normal range (n=20) is 0.013-0.27 micromol/mmol creatinine. Measured SA newborn bloodspot normal range (n=152) is 0-0.30 micromol/L. Bloodspots from children with hepatorenal tyrosinemia type 1, and kept at room temperature for up to 7 years, afforded SA concentrations of 0.9-5.7 micromol/L.
Structural isomers of a terminal phosphinidene complex (1987)

The reactions of ArP(Li)(SiMe3)(Ar = 2,4,6-But3C6H2) with (η5-C5H5)2ZrCl2 and (η5-C5H4Me)2WCl2 afford (η5-C5H5)2Zr(Cl)P(SiMe3)(Ar) and two isomers of composition (η5-C5H4Me)[graphic omitted]Ar)], respectively, the structures of which have been determined.
Determination of organic acids and phosphate in soil aqueous extracts by capillary zone electrophoresis (1999)

Abstract Organic acids and phosphate were determined in soil aqueous extracts by capillary zone electrophoresis using indirect UV detection. The electrolyte system was 10 mM sodium benzoate with 0.5 mM tetradecyltrimetyl‐ammonium bromide as flow modifier at pH 4.0, pH 4.5, or pH 5.0. This methodology was adequate to determine organic acids and phosphate in soil samples, but the major inorganic anions interfered in the determination. In all the samples of soil extracts, the presence of phosphate was detected. Acetate was found in most of the samples and lactate and formate in some of them.
Γ-X Tunnelling in GaAs/AlAs/GaAs Heterostructure (1998)

Tunnelling, via X-valley related states, is investigated in GaAs/AlAs/GaAs single-barrier structures. The features in the tunnel current, which are experimentally observed, are associated with resonant tunnelling through the X-valley AlAs quantum well states derived from the conduction band minima, both perpendicular (X x and X y ) and parallel (X z ) to the (100) growth direction and the Si-donor states linked to the X valley. Tunnelling through the impurity states associated with X z and X x y valleys are observed for the first time.
Réseaux de santé. Droit des malades. Loi du 4 mars 2002 (2003)

International audience
Four-Degree-of-Freedom Parallel Mechanism Mobile Robots (2008)

This paper proposes the parallel mechanism mobile robot whose body is a parallel mechanism. Its notable feature is that it can elevate another mobile robot to a high level to which the latter alone cannot ascend. In serial manipulators, the weight of actuators for distal joints is a load on actuators for proximal joints. On the other hand, actuators support the output platform of a parallel manipulator in parallel. Therefore the parallel mechanism body can elevate a heavier object than a serial manipulator without elevating most of or all of its own actuators. In addition, the output platform can be made wide enough to load another robot. As an example of such a parallel mechanism mobile robot, we develop a four-DOF parallel mechanism mobile robot. Its advantage is that the platform can be kept horizontal in rough terrain. We experimentally verify that the robot can elevate another mobile robot of almost the same weight.
Differentially Private Cloud-Based Multi-Agent Optimization with Constraints (2017)

We present an optimization framework that solves constrained multi-agent optimization problems while keeping each agent's state differentially private. The agents in the network seek to optimize a local objective function in the presence of global constraints. Agents communicate only through a trusted cloud computer and the cloud also performs computations based on global information. The cloud computer modifies the results of such computations before they are sent to the agents in order to guarantee that the agents' states are kept private. We show that under mild conditions each agent's optimization problem converges in mean-square to its unique solution while each agent's state is kept differentially private. A numerical simulation is provided to demonstrate the viability of this approach.
Retinal Ischemia/Reperfusion Injury Is Mediated by Toll-like Receptor 4 Activation of NLRP3 Inflammasomes (2014)

These findings suggest that TLR4-signaling activation, triggered by damage-associated molecular patterns, regulates the activation of the NLRP3 inflammasomes and is responsible for the function of the retina in retinal IR injury.
Preparation of an Imidazole-Conjugated Oligonucleotide (2000)

Postsynthetic modification of an oligonucleotide with an imidazole functional group was achieved by formation of an amide bond between the functional group and a single 2'-amino-2'-deoxyuridine, d-aU, of the oligonucleotide. The succinimidyl ester of N-glutaryl-histamine was synthesized under anhydrous conditions and added to the oligonucleotide in an acetonitrile-containing buffer at pH 8.0. Formation of the conjugate was assayed by digestion with snake venom phosphodiesterase and bacterial alkaline phosphatase, followed by reversed-phase HPLC to resolve constituent nucleosides. The disappearance of a peak corresponding to d-aU and the appearance of a peak that coelutes with authentic 2'-(N-glutaryl-N'-histaminyl)-2'-deoxyuridine confirmed the formation of the conjugate. Imidazole-conjugated oligonucleotides may have utility as antisense agents capable of hydrolyzing RNA.
Oligonucleotides specific for pathogenic and saprophytic leptospira occurring in water (2006)

Sets of primers specific for both pathogenic (SPL) and saprophytic (SSL) Leptospira were designed from ribosomal 16S genes (rrs) available in databases. They were used as two sets of primer pairs for the PCR amplification of known pathogenic and saprophytic strains. It was possible to identify pathogenic strains by the use of SPL primers and saprophytic ones by SSL primers. Serovars from L. meyeri, of controversial pathogenicity status, confirmed the heterogeneity of the species representatives in this respect. Serovars ranarum, sofia and perameles were amplified by SPL and not SSL. Conversely, serovar semaranga was amplified by SSL and not SPL. In order to use SPL primers for the detection of pathogenic leptospires from a natural water environment, we set up an additional semi-nested PCR by employing a second internal primer which succeeded in detecting as few as 5 pathogenic leptospires per ml of water.
Influencia de las Técnicas de Variación de Velocidad de Cabezal en la Estabilidad del Proceso de Fresado: Estudio Comparativo (2004)

La aparicion de vibraciones autoexcitadas en el proceso de fresado es uno de los mayores inconvenientes a la hora de incrementar el ratio de arranque de viruta. La estabilidad del proceso, para cada conjunto maquina/herramienta/material-pieza, y para cada tipo de operacion, viene determinada por los denominados diagramas de lobulos, que discriminan las condiciones de corte estable e inestable. Para hacer frente al fenomeno del chatter, algunos autores han propuesto el empleo de estrategias encaminadas a distorsionar la excitacion provocada por el golpeo periodico de los dientes de la fresa sobre la pieza. Entre estas tecnicas cabe senalar las de variacion de velocidad de cabezal (SSV), que se tratan en este articulo. Tras una breve revision del estado del arte en este campo, tanto en el modelado como en la aplicacion de estas tecnicas, se presenta un modelo numerico de corte, contrastado y validado mediante ensayos experimentales. Posteriormente, y a partir de un estudio en simulacion, se presentan y comparan distintas estrategias de mecanizado basadas en la variacion de la velocidad del cabezal. Asi, se examina la influencia de estas estrategias en los diagramas de lobulos para distintas condiciones de operacion. Los resultados, analizados al final del articulo, son un paso previo a su validacion experimental e implementacion industrial.
Modern Diagnostic X-Ray Sources (2021)

Now fully updated, the second edition of Modern Diagnostic X-Ray Sources: Technology, Manufacturing, Reliability gives an up-to-date summary of X-ray source technology and design for applications in modern diagnostic medical imaging. It lays a sound groundwork for education and advanced training in the physics of X-ray production, X-ray interactions with matter, and imaging modalities and assesses their prospects. The book begins with a comprehensive and easy-to-read historical overview of X-ray tube and generator development, including key achievements leading up to the current technological and economic state of the field. The book covers the physics of X-ray generation, including the process of constructing X-ray source devices. The stand-alone chapters can be read in order or in selections. They take you inside diagnostic X-ray tubes, illustrating their design, functions, metrics for validation, and interfaces. The detailed descriptions enable objective comparison and benchmarking. This detailed presentation of X-ray tube creation and functions enables you to understand how to optimize tube efficiency, particularly with consideration for economics and environmental care. It also simplifies faultfinding. Along with covering the past and current state of the field, the book assesses the future regarding developing new X-ray sources that can enhance performance and yield greater benefits to the scientific community and to the public. After heading international R&amp;D, marketing and advanced development for X-ray sources with Philips, and working in the X-ray industry for more than four decades, Rolf Behling retired in 2020 and is now the owner of the consulting firm XtraininX, Germany. He holds numerous patents and is continuously publishing, consulting and training.
A phase I study of buparlisib (BKM120) with bevacizumab (BEV) in patients (pts) with metastatic renal cell carcinoma (mRCC) progressing on prior vascular endothelial growth factor (VEGF) therapies. (2015)

4559 Background: BKM120 is a pan-PI3K inhibitor with demonstrated activity in advanced solid tumors. The primary aim of this study was to determine the maximum tolerated dose (MTD) and dose limiting toxicities (DLTs) of BKM120 + BEV. Secondary objectives included safety, efficacy, and biomarker discovery. Methods: This was a 3+3 dose escalation study of BKM120 (60-100 mg/day (d)) + BEV (10 mg/kg every 2 weeks). After the MTD was defined, 14 pts were accrued to the expansion cohort. Results: A total of 32 pts were accrued (5 treated at 60 mg/d, 19 at 80 mg/d (2 remain on therapy), 6 at 100 mg/d, and 2 never received therapy). The majority had clear cell histology (88%) and 50% had ≥2 prior lines of systemic therapy. The MTD of BKM120 was 80 mg/d. With the exception of 1 case of cognitive disturbance deemed related to both agents, all DLTs (Table 1) were attributed to BKM120. 28 pts discontinued therapy: 16 due to progression, 7 dueto toxicity, 1 due to death, and 4 due to other reasons. Toxicity leading to therapy discontinuation included rash/pruritis, transaminitis, elevated lipase/amylase, suicidal ideation, and cognitive disturbances. Of the 30 pts who received at least 1 dose, 13% had a partial response (PR) (95% CI 4%, 31%), 50% had stable disease (SD), and 20% had progressive disease (PD). Of the 19 pts treated at the MTD, 11% had a PR (95% CI 1%, 33%), 53% had SD, and 16% had PD. The median time-to-treatment failure (TTF), progression-free survival (heavy censoring) and overall survival were 4 (95% CI 2, 9), 9 (95% CI 2, 9), and 18 (95% CI 4, not reached) months (mos) for the total cohort and 4 (95% CI 2, 9), 6 (95% CI 2, 9), and 13 (95% CI 5, not reached) mos for pts treated at the MTD, respectively. Of the 9 pts evaluated, 2 had activating PI3K mutations. One achieved a PR (TTF 13 mos) and the other achieved SD with 16% tumor shrinkage (TTF 9 mos). Conclusions: BKM120 at 80 mg/d + BEV was a tolerable regimen with preliminary activity in VEGF-refractory mRCC. Clinical trial information: NCT01283048.Summary of DLTs. Case DLT Grade BKM Dose 11 Anxiety 3 100 mg Depression 3 Suicidal ideation 3 12 Anorexia 3 100 mg Weight loss 3 15 Cognitive disturbance 2* 80 mg *≥1 CTCAE grade level increase defined as DLT.
BIOTRANSFORMATION OFα-SANTONIN (1997)

Bacillus cereus UI-1477 was able to convert α-santonin into one major metabolite with a 64% yield. The structure of the obtained metabolite was suggested with 1D and 2D 1H-, 13C-NMR as 1,2-dihydrosantonin. Biological evaluation showed a complete loss of both anthelmintic and antimicrobial activity of 1,2-dihydrosantonin in comparison to α-santonin.
A new resonant tunneling transistor fabricated by cleaved edge overgrowth (2002)

A new three-terminal resonant tunneling transistor is realized by the molecular beam epitaxial cleaved edge overgrowth technique in GaAs/AlGaAs system. In addition to negative differential resistance, this device exhibits both positive and negative transconductance behavior which can find useful applications in high speed logic circuits.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
One-dimensional transient analysis of volumetric heating for laser drilling (2006)

Generally laser energy is considered to interact only with the substrate surface, as in metals, where the laser beam does not propagate into the substrate beyond a very small absorption depth. There are, however, many instances, particularly for ceramics and polymers, where the laser beam can penetrate into the substrate to substantial depths depending on the laser wavelength and laser-material interaction characteristics. Specifically there are polymeric dielectrics used as multilayer electronic substrates in which a laser beam of wavelength 9.3μm can penetrate into the substrate. The laser energy interacts at the substrate surface as well as inside the substrate. This particular aspect of laser-material interactions is important in laser drilling of blind microvias in polymeric multilayer electronic substrates. A one-dimensional transient heat conduction model including vaporization parameters is constructed to analyze this behavior. The absorption coefficient of the dielectric is also considered in this model and the problem is solved analytically. The microvia drilling speed, temperature distribution in the dielectric, and the thickness of the residue along the microvia walls and at the bottom of the microvia are studied for different laser irradiation conditions. An overheated metastable state of material is found to exist inside the workpiece. The overheating parameters are calculated for various laser drilling parameters and are used to predict the onset of thermal damage and to minimize the residue.