gebhart/patrepeval huggingface dataset:
t(1;2)(q21;p23) and t(2;3)(p23;q21): Two Novel Variant Translocations of the t(2;5)(p23;q35) in Anaplastic Large Cell Lymphoma (1999)

Cytogenetic investigations in two cases of anaplastic large cell lymphoma (ALCL) showed novel variants of the classical (2;5)(p23;q35) translocation, namely a t(1;2)(q21;p23) and a t(2;3)(p23;q21). The tumor cells in both cases gave positive immunohistochemical labeling for ALK protein (with both monoclonal and polyclonal antibodies), demonstrating that these translocations induce aberrant expression of this kinase and suggesting that genes other than NPM can activate the ALK gene in ALCL. These two cases were shown by an in vitro kinase assay to express ALK kinases (104 kD and 97 kD, respectively), which differed in size from the classical NPM-ALK fusion product (80 kD). Moreover, ALK expression was confined to the cytoplasm of the tumor cells in each case, supporting the hypothesis that the observed nuclear localization of NPM-ALK in classical ALCL is not the site of oncogenic activity of the ALK kinase.
Countercation Effect on CO2 Binding to Oxo Titanate with Bulky Anilide Ligands (2018)

This work focuses on nucleophilic activation of CO<sub>2</sub> at the anionic terminal oxo titanium tris(anilide) complexes [(Solv)<sub>n</sub> M][OTi(N[<sup>t</sup> Bu]Ar)<sub>3</sub> ]<sub>m</sub> with M=Li, Na, K, Mg, MgMe, AlCl<sub>2</sub> , AlI<sub>2</sub> ; Ar=3,5-Me<sub>2</sub> C<sub>6</sub> H<sub>3</sub> ; Solv=Et<sub>2</sub> O, THF, 12-crown-4, 2,2,2-cryptand; n, m=1-2. The CO<sub>2</sub> binding strength to the terminal oxo ligand of [OTi(N[<sup>t</sup> Bu]Ar)<sub>3</sub> ]<sup>-</sup> ([1]<sup>-</sup> ) and the stability of the resulting carbonate moiety [O<sub>2</sub> COTi(N[<sup>t</sup> Bu]Ar)<sub>3</sub> ]<sup>-</sup> ([2]<sup>-</sup> ) are highly dependent on the Lewis acidity of the countercation. We report herein on CO<sub>2</sub> binding as a function of countercation and countercation coordination environment, and comment in this respect on the bottom and upper limits of the cation Lewis acidity. Thermodynamic parameters are provided for oxo complexes with lithium as countercation, that is, [(Et<sub>2</sub> O)<sub>2</sub> Li][1] and [(12-c-4)Li][1].
Abstract 16888: Computational Simulations of Coronary Artery Flow in Supravalvular Aortic Stenosis (2012)

Introduction: Supravalvular aortic stenosis (SVAS) and aortic coarctation (CoA) are sources of ventricular afterload, which can lead to a mismatch between coronary artery flow (CF) and cardiac oxyg...
Coherence Analysis Between Respiration And Ppg Signal By Bivariate Ar Model (2009)

PPG is a potential tool in clinical applications. Among such, the relationship between respiration and PPG signal has attracted attention in past decades. In this research, a bivariate AR spectral estimation method was utilized for the coherence analysis between these two signals. Ten healthy subjects participated in this research with signals measured at different respiratory rates. The results demonstrate that high coherence exists between respiration and PPG signal, whereas the coherence disappears in breath-holding experiments. These results imply that PPG signal reveals the respiratory information. The utilized method may provide an attractive alternative approach for the related researches.
Les émulsifiants dans les produits de boulangerie industrielle : modes d'action, rôles et utilisations. (2004)

peer reviewed
A continuous-time walking pattern generator for realizing seamless transition between flat-contact and heel-to-toe walking (2022)

A planning algorithm that can generate continuous-time walking patterns including the seamless transition between flat-contact and heel-to-toe walking gaits is proposed. The planner makes use of the closed-form solution of a modified linear inverted pendulum mode which includes the ZMP and the weight ratio of each foot explicitly in its dynamics. The heel-to-toe movement of each foot is directly parameterized by the ZMP, and therefore consistency between the foot movement and the low-dimensional dynamics is ensured. In simulations with a 32 DoF model of a life-sized humanoid robot, fast human-like walking at the maximum speed of 4.6 km/h was achieved.
Board leadership: balancing entrepreneurship and strategy with accountability and control (2003)

Argues that effective board leadership requires directors to achieve a balance between entrepreneurship (i.e. paying attention to strategy, corporate renewal and innovation on the one hand) and corporate governance. Posits that medium sized firms have a dilemma in knowing how to expand their businesses in a rapid fashion. Highlights how companies manage this type of move from a corporate type of governance to a more corporate entrepreneurship.
EFFICACY OF MARIBAVIR IN VALGANCICLOVIR-RESISTANT CYTOMEGALOVIRUS RETINITIS (2023)

This patient's results suggest that systemic maribavir is an effective treatment for treatment-resistant cytomegalovirus retinitis.
On effects of feedback delay in secure buffer-aided relay networks (2015)

Cooperative communication is one of the fundamental technologies for the future wireless networks including 5G to improve communication reliability and enhance spectrum efficiency. In this paper, we consider a buffer-aided relay that performs opportunistic selection of the legitimate users in presence of an eavesdropper under physical layer security constraints. The channel state information of users are subjected to delays in the feedback channel. Closed form expression for outage probability is derived based on link selection scheme. Numerical results present the minimized secrecy outage probability by optimizing selection parameters. It is found that although feedback delay degrades the performance, the increase in number of legitimate users helps to improve the performance by exploiting multiuser diversity.
Implantable Telemetry in Biomedical Research (1984)

Animal models of human physiology, pathology, and pharmacology are indispensable tools in biomedical research. Totally implantable radiotelemetry systems provide an invaluable appendage to animal models because these systems are a means for acquisition of otherwise unavailable experimental data. Implantable systems for measurement of velocity, volume flow, dimension, pressure, strain, bioelectric potential, temperature, and pH in selected applications are discussed.
Control of Light Transmission through Opaque Scattering Media in Space and Time (2011)

We report the first experimental demonstration of combined spatial and temporal control of light transmission through opaque media. This control is achieved by solely manipulating spatial degrees of freedom of the incident wave front. As an application, we demonstrate that the present approach is capable of forming bandwidth-limited ultrashort pulses from the otherwise randomly transmitted light with a controllable interaction time of the pulses with the medium. Our approach provides a new tool for fundamental studies of light propagation in complex media and has the potential for applications for coherent control, sensing and imaging in nano- and biophotonics.
The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation (2015)

Intestinal helminths are potent regulators of their host's immune system and can ameliorate inflammatory diseases such as allergic asthma. In the present study we have assessed whether this anti-inflammatory activity was purely intrinsic to helminths, or whether it also involved crosstalk with the local microbiota. We report that chronic infection with the murine helminth Heligmosomoides polygyrus bakeri (Hpb) altered the intestinal habitat, allowing increased short chain fatty acid (SCFA) production. Transfer of the Hpb-modified microbiota alone was sufficient to mediate protection against allergic asthma. The helminth-induced anti-inflammatory cytokine secretion and regulatory T cell suppressor activity that mediated the protection required the G protein-coupled receptor (GPR)-41. A similar alteration in the metabolic potential of intestinal bacterial communities was observed with diverse parasitic and host species, suggesting that this represents an evolutionary conserved mechanism of host-microbe-helminth interactions.
Design, Synthesis, and Evaluation in Vitro of Quinoline-8-carboxamides, a New Class of Poly(adenosine-diphosphate-ribose)polymerase-1 (PARP-1) Inhibitor (2008)

Poly(ADP-ribose)polymerase-1 is an important target enzyme in drug design; inhibitors have a wide variety of therapeutic activities. A series of quinoline-8-carboxamides was designed to maintain the required pharmacophore conformation through an intramolecular hydrogen bond. 3-Substituted quinoline-8-carboxamides were synthesized by Pd-catalyzed couplings (Suzuki, Sonogashira, Stille) to 3-iodoquinoline-8-carboxamide, an efficient process that introduces diversity in the final step. 2-Substituted quinoline-8-carboxamides were prepared by selective Pd-catalyzed couplings at the 2-position of 2,8-dibromoquinoline, followed by lithium-bromine exchange of the intermediate 2-(alkyl/aryl)-8-bromoquinolines and reaction with trimethylsilyl isocyanate. The intramolecular hydrogen bond was confirmed by X-ray and by NMR. The SAR of the 3-substituted compounds for inhibition of human recombinant PARP-1 activity showed a requirement for a small narrow group. Substituents in the 2-position increased potency, with the most active 2-methylquinoline-8-carboxamide having IC(50) = 500 nM (IC(50) = 1.8 microM for 5-aminoisoquinolin-1-one (5-AIQ, a standard water-soluble inhibitor)).
A Short Calcium Infusion in the Diagnosis of Medullary Thyroid Carcinoma (1974)

A brief calcium infusion has been utilized as a provocative test for calcitonin secretion in patients with medullary thyroid carcinoma. One hundred and fifty mg calcium was infused over 5–10 min and plasma samples collected at intervals up to 1 hr for calcitonin measurements. Seven infusions in 4 patients with medullary tumor produced a significant increase of plasma calcitonin over basal concentrations. In one patient with normal (nondiagnostic) basal calcitonin, the calcium infusion produced a diagnostic increase in hormone concentration. The infusions were well tolerated and the plasma calcium increase was less than one milligram. Our results suggest that this short calcium infusion, with calcitonin measurements made before and 10–30 min after the beginning of infusion provides a reliable, convenient, and safe provocative procedure for calcitonin secretion in medullary thyroid carcinoma suspects.
The Fat‐Fed Apolipoprotein E Knockout Mouse Brachiocephalic Artery in the Study of Atherosclerotic Plaque Rupture (2010)

Atherosclerosis has been studied in animals for almost a century, yet the events leading up to the rupture of an atherosclerotic plaque (the underlying cause of the majority of fatal thrombosis formation) have only been studied in the past decade, due in part to the development of a mouse model of spontaneous plaque rupture. Apolipoprotein E knockout mice, when fed a high-fat diet, consistently develop lesions in the brachiocephalic artery that rupture at a known time point. It is therefore now possible to observe the development of lesions to elucidate the mechanisms behind the rupture of plaques. Critics argue that the model does not replicate the appearance of human atherosclerotic plaque ruptures. The purpose of this review is to highlight the reasons why we should be looking to the apolipoprotein E knockout mouse to further our understanding of plaque rupture.
Device-Therapie nach akutem Koronarsyndrom (2014)

Acute coronary syndromes are seldom accompanied by high degree AV blocks. Implantation of a permanent pacemaker is rarely necessary.There is a high incidence of ventricular tachyarrhythmias during the acute phase of myocardial infarctions. Sustained VT or VF beyond 48 hours of the infarction indicate the need for an implantable cardioverter-defibrillator. If left ventricular ejecion fraction remains ≤35 % for >40 days an ICD might be indicated for primary prophylaxis.If early after infarction a device implantation becomes necessary, biventricular stimulation should be used if ventricular pacing is necessary or LBBB with markedly increased QRS-duration is present.
Mechanisms of transplant rejection after the establishment of donor-specific tolerance (2020)

Abstract Patients weaned from immunosuppressive drugs can reject their graft after years of stability, often after an infection. We have modeled this in mice: infection with Listeria monocytogenes (Lm) at the maintenance phase of tolerance can precipitate rejection of a cardiac allograft. Here, we investigated which alloreactive Tconvs may mediate rejection after Lm infection. To track the function of allospecific Tconvs, we seeded tracer TCR75 cells, which recognize I-Ab-restricted donor Kd peptide, into B6 mice prior to Balb/c cardiac transplantation with or without tolerance induction by anti-CD154 + Balb/c splenocytes. ≥35 days post-transplantation, TCR75 cells persisting in tolerant mice developed a PD-1hi CD127lo exhausted-like phenotype and expressed the anergy markers FR4 and CD73. TCR75 cells were dysfunctional, exhibiting 10-fold less recall expansion compared to memory cells and lacked IFNγ and TNF production upon re-stimulation. Intriguingly, TCR75 cells in tolerant hosts remained dysfunctional after Lm infection, suggesting that they may not participate in infection-triggered rejection. Having found that programming T cell dysfunction in tolerance required persistence of the allograft for ~3 weeks, we tested whether T cells specific for alloantigens expressed transiently after transplantation, such as donor MHC Class II, remain functional during tolerance and may mediate rejection after Lm infection. We used tracer TEa cells specific for a donor Class II Eα peptide presented on I-Ab. During tolerance, TEa cells remained PD-1lo and CD73lo, and retained recall expansion and TNF production. We conclude that functional allospecific Tconvs present during tolerance may pose a previously unappreciated risk to the graft.
orf4 of the Bacillus cereus sigB Gene Cluster Encodes a General Stress-Inducible Dps-Like Bacterioferritin (2009)

The function of orf4 in the sigB cluster in Bacillus cereus ATCC 14579 remains to be explored. Amino-acid sequence analysis has revealed that Orf4 is homologous with bacterioferritins and Dps. In this study, we generated an orf4-null mutant and produced recombinant protein rOrf4 to establish the role of orf4. In vitro, the purified rOrf4 was found to exist in two distinct forms, a dimeric form and a polymer form, through size exclusion analysis. The latter form exhibited a unique filament structure, in contrast to the typical spherical tetracosamer structure of bacterioferritins; the former can be induced to form rOrf4 polymers immediately after the addition of FeCl(2). Catalysis of the oxidation of ferrous irons by ferroxidase activity was detected with rOrf4, and the mineralized irons were subsequently sequestered only in the rOrf4 polymer. Moreover, rOrf4 exerted DNA-protective activity against oxidative damage via DNA binding in a nonspecific manner, as is seen with Dps. In vivo, deletion of orf4 had no effect on activation of the alternative sigma factor sigma(B), and therefore, orf4 is not associated with sigma(B) regulation; however, orf4 can be significantly upregulated upon environmental stress but not H(2)O(2) treatment. B. cereus strains with constitutive Orf4 expression exhibited a viability higher than that of the orf4-null mutant, under specific oxidative stress or heat shock. Taken together, these results suggest that Orf4 functions as a Dps-like bacterioferritin in response to environmental stress and can provide cell protection from oxidative damage through iron sequestration and DNA binding.
Partial discharge measurement and pattern recognition in gas insulated switchgear (2011)

Gas insulated switchgear (GIS) has been widely used as main switching equipment in the power substation, because it has good insulation and high reliability. However, if the switchgear is with defect or beyond the server life, the ability of the insulation may be degradation. Therefore, the detecting technology and fault diagnostic method on GIS has become more and more importance. In this paper, four common defect types of 15 kV switchgears are established, and a commercial inductive sensor measures the current signal caused by the partial discharge (PD) phenomenon. Next transfer this current signal into 3D PD patterns, through these PD patterns we can find the differences characteristic among these testing models. Finally features extract and pattern recognition based on neural network (NN). This detection could determine types of failure and so assist in utility maintenance.
Hysterese in der Steifigkeit von Linearführungen im Kontext sensorgestützter Lastbestimmung (2021)

Steigerung der Betriebssicherheit von Windenergieanlagen durch kooperative Berechnungsansätze bei der Wälzlagerauslegung ..... 1
Virus and cytotoxic T lymphocytes: crucial role of viral peptide secondary structure in major histocompatibility complex class I interactions (1993)

Viral antigens are presented to cytotoxic T lymphocytes (CTLs) by H-2-restricted major histocompatibility complex (MHC) glycoproteins. Binding of the endogenously processed viral peptides (epitopes) to their specific MHC molecules is an early intracellular event in the recognition process and is necessary for subsequent killing of virus-infected cells by virus-specific CTLs. It is now well established that interaction between a viral antigenic peptide and MHC is dependent on the primary structure (length and amino acid sequence) of that antigen. Here we show, using the H-2Db-restricted epitope GP277-286 of lymphocytic choriomeningitis virus as a model, that the secondary structure (conformation) of the viral sequence also plays a crucial role in the binding of a viral antigen to MHC glycoprotein and in its subsequent presentation to virus-specific CTLs.
The advanced access content system's use of digital watermarking (2006)

The Advanced Access Content System (AACS) is the copy protection scheme for the new generation of high-definition DVD movies. Fundamentally,AACS is based on crypto-graphic principles. However, it has found a limited use for digital watermarking: first for playback control, and then, to a lesser extent,for forensics. This paper characterizes the forensic approach, and then describes AACS's "theatrical" and "consumer "watermarks and how they are used.
Intracellular Ca2+ in pancreatic acinar cells: Regulation and role in stimulation of enzyme secretion (1987)

Evidence for a primary role for intracellular Ca2+ in the stimulation of pancreatic enzyme secretion is reviewed. Measurements of cytoplasmic free Ca2+ concentration have allowed direct demonstration of its importance in triggering enzyme secretion and defined the concentration range over which membrane Ca2+ pumps must work to regulate intracellular Ca2+. Current evidence suggests a key role for the Ca2+, Mg-ATPase of rough endoplasmic reticulum in regulating intracellular Ca2+ and accumulating a Ca2+ store which is released by the action of inositol-1,4,5 trisphosphate following stimulation of secretion.
Three-phase phase-lock loop for distorted utilities (2007)

A novel three-phase phase-locked loop (PLL) structure suitable for phase and angular frequency derivation from distorted ac utility voltages is presented. The proposed PLL has a simple structure; a conventional three-phase PLL followed by a proportional-integral (PI)-controlled moving average filter together with a phase-locking algorithm. The objective of the proposed technique is to capture the fundamental phase angle and angular frequency of three-phase clean, distorted, balanced or unbalanced ac utilities. The PLL gives fast, accurate angular frequency and phase locking and is robust to utility distortion such as line notching, random noise, voltage imbalance, phase loss, phase imbalance, harmonics, dc offsets and frequency variation. The analysis presented substantiates the immunity of the proposed PLL to unbalanced and distorted utility conditions. The PLL technique is simulated and digital signal processor (DSP)-implemented for a three-phase system to verify the analytical results. The simulated and experimental results, for numerous utility conditions, demonstrate its phase-tracking ability, whereas the conventional technique fails to lock accurately in highly distorted, three-phase grid-connected operation.
Laser-Induced Polymerization of Surface Adsorbed Molecules (1990)

The controllability of the chemical composition of acrylic compounds was investigated in ultrathin polymerized films by using a polymerization process in vacuo with a vacuum UV excimer laser. Four different acrylic compounds were polymerized by this process. The analysis of X-ray photoelectron spectroscopy showed that the chemical compositions of polymer film from ethylacrylate were well-preserved monomer compositions. The insulation characteristics of the ultrathin films obtained from the optimized conditions were found to be sufficient for producing a MIS device on n-type GaAs substrates.
The Aspergillus fumigatus Transcriptional Regulator AfYap1 Represents the Major Regulator for Defense against Reactive Oxygen Intermediates but Is Dispensable for Pathogenicity in an Intranasal Mouse Infection Model (2007)

Macrophages and neutrophils kill the airborne fungal pathogen Aspergillus fumigatus. The dependency of this killing process on reactive oxygen intermediates (ROI) has been strongly suggested. Therefore, we investigated the enzymatic ROI detoxifying system by proteome analysis of A. fumigatus challenged by H(2)O(2). Since many of the identified proteins and genes are apparently regulated by a putative Saccharomyces cerevisiae Yap1 homolog, the corresponding gene of A. fumigatus was identified and designated Afyap1. Nuclear localization of a functional AfYap1-eGFP fusion was stress dependent. Deletion of the Afyap1 gene led to drastically increased sensitivity of the deletion mutant against H(2)O(2) and menadione, but not against diamide and NO radicals. Proteome analysis of the DeltaAfyap1 mutant strain challenged with 2 mM H(2)O(2) indicated that 29 proteins are controlled directly or indirectly by AfYap1, including catalase 2. Despite its importance for defense against reactive agents, the Afyap1 deletion mutant did not show attenuated virulence in a murine model of Aspergillus infection. These data challenge the hypothesis that ROI such as superoxide anions and peroxides play a direct role in killing of A. fumigatus in an immunocompromised host. This conclusion was further supported by the finding that killing of A. fumigatus wild-type and DeltaAfyap1 mutant germlings by human neutrophilic granulocytes worked equally well irrespective of whether the ROI scavenger glutathione or an NADPH-oxidase inhibitor was added to the cells.