gebhart/patrepeval huggingface dataset:
TOM1 , an Arabidopsis gene required for efficient multiplication of a tobamovirus, encodes a putative transmembrane protein (2000)

Host-encoded factors play an important role in virus multiplication, acting in concert with virus-encoded factors. However, information regarding the host factors involved in this process is limited. Here we report the map-based cloning of an Arabidopsis thaliana gene, TOM1, which is necessary for the efficient multiplication of tobamoviruses, positive-strand RNA viruses infecting a wide variety of plants. The TOM1 mRNA is suggested to encode a 291-aa polypeptide that is predicted to be a multipass transmembrane protein. The Sos recruitment assay supported the hypothesis that TOM1 is associated with membranes, and in addition, that TOM1 interacts with the helicase domain of tobamovirus-encoded replication proteins. Taken into account that the tobamovirus replication complex is associated with membranes, we propose that TOM1 participates in the in vivo formation of the replication complex by serving as a membrane anchor.
The effects of migration on ulcerative colitis: a three-year prospective study among Europeans and first- and second-generation South Asians in Leicester (1991–1994) (1999)

OBJECTIVE: Our aim was to measure prospectively the incidence of ulcerative colitis in Leicester City and to compare this with a previous retrospective study in the same area. We also sought to compare the incidence and disease extent in the European community with that of the South Asian community and to compare the disease extent between first- and second-generation South Asian migrants. METHODS: A 3-yr prospective study of ulcerative colitis in the city of Leicester took place from October 1, 1991 to September 30, 1994 and included all cases resident in Leicester City and diagnosed as having ulcerative colitis, regardless of the extent and severity of the disease. RESULTS: Extensive colitis was commoner in second-generation migrants than in the first generation (χ2 = 4.3, p = 0.04) and was comparable to the European community. The annual average incidence of ulcerative colitis was 9.1/105 population/yr (95% confidence interval [CI] 7.1–11.3), which is similar to the previous retrospective study. However, the annual average incidence of ulcerative colitis in the European population was 7.0/105 population/yr (95% CI 5–9.5), whereas that of the South Asian population was 17.2/105 population/yr (95% CI 11.8–24.3), confirming that the risk of ulcerative colitis in this particular community is exceptionally high. CONCLUSIONS: These early results suggest that the disease pattern follows that of the indigenous population after only one generation and requires monitoring over the next decade. The incidence of ulcerative colitis in the South Asian population is high and continuing to rise.
Half-wave dielectric rod resonator filter (2004)

A new half-wave dielectric rod resonator and its filter realization are proposed for satellite input multiplexer applications. Single resonator and a 10-pole filter with 8 real and complex transmission zeros are modeled and designed to desired specification by using efficient optimization technique and a finite element method solver. Excellent filter responses are obtained.
Passive picocell: a new concept in wireless networkinfrastructure (1997)

A completely passive radio access point for future high capacity, short range wireless networks has been demonstrated. This concept is based on a single component, an unbiased electroabsorption modulator, which acts as a passive transceiver at the remote side of an analogue optical link.
1112 Characterization of Duox2 as a Candidate Glutathione Peroxidase-Deficiency-Associated- Colitis, Gdac1, Gene in Mice (2012)

Background & Aims: Micro-RNAs (miRNAs) are short, non-coding RNAs that regulate gene expression post transcriptionally. Several studies have demonstrated distinct miRNA profiles in a wide range of human disorders including inflammatory bowel disease and colon cancer. Surprisingly little is known about miRNA responses in immune cells that are challenged with relevant proinflammatory stimuli, i.e. cytokines or pathogen-associated microbial patterns. With this study we thus aim to generate a prototypic picture of inflammatory miRNA networks in monocytes as a relevant immune cell population and to understand functional consequences of selected regulated miRNAs on inflammatory signalling pathways. Methods: Levels of 330 miRNAs upon stimulation with a panel of pro-inflammatory components such as microbial pattern molecules (flagellin, diacylated lipopeptide lipopolysaccharide, muramyl dipeptide), infection with Listeria monocytogenes and TNF-alpha as pro-inflammatory control in primary human monocytes were qunatified using real time PCR. Selected miRNAs were verified in parallel in LPMNCs and biopsies from IBD patients. Transfection of premiRs and antago-miRs in THP1 monocytic cells were employed in order to understand functional consequences of miRNA regulation. Results: We identified distinct miRNA response clusters pointing to unique and shared mechanisms for different proinflammatory stimuli even in a single cell type. Additionally, we identified potential target genes of three selected miRNAs miR-129-5p, miR-146a and miR-378 which were part of PAMP-specific response clusters by transfecting THP1 monocytes with the corresponding preor antimiRNAs . The miRNAs induced distinct transcriptomal signatures, e.g. overexpression of miRNA129-5p, which was selectively upregulated by the NOD2-elicitor MDP, led to an upregulation of DEFB1, IRAK1, FBXW7 and IKK-gamma (Nemo). Interestingly, regulation of several overlap miRNAs shared between stimuli could also be detected in samples from IBD patients. Conclusions: Our findings on co-regulated clusters of miRNAs support the hypothesis that miRNAs act in functional groups. This study indicates that miRNAs play an important role in fine-tuning inflammatory mechanisms. Investigation in the field of miRNA responses in intestinal inflammation will help to understand their effects on gene expression and may close the regulatory gap between mRNA and protein expression in inflammatory diseases.
Efficacy and Safety of Topical WBI-1001 in the Treatment of Atopic Dermatitis: Results From a Phase 2A, Randomized, Placebo-Controlled Clinical Trial (2010)

sion was used to examine which variables of interest would explain unique variance associated with sunbathing intentions and intentions to sun protect. For both analyses, age, sex, skin type, and perceived susceptibility were entered in step 1, followed by the 3 appearance-based tanning motives (appearance reasons to tan, appearance reasons not to tan, and sociocultural influences) entered in step 2. The overall R 2 for both analyses was significant and indicated that a high level of variance was accounted for by the predictors (sunbathing R 2 =.50; sun protection R 2 =.62). In both regressions, appearance subscales of the PARTS explained significant variance beyond that explained by age, sex, skin type, and perceived susceptibility (Table ). Appearance reasons to tan were significantly associated with sunbathing intentions (P .01) but not with sun protection intentions (P = .07): adolescents who positively endorsed appearance reasons to tan also reported more frequent intentions to sunbathe in the next 12 months and fewer intentions to sun protect. Appearance reasons not to tan were significantly associated with sunbathing intentions (P=.03) and with sun protection intentions (P.01): participants scoring higher on appearance reasons not to tan also reported fewer intentions to sunbathe and higher intentions to sun protect.
TLR2 Agonistic Small Molecules: Detailed Structure–Activity Relationship, Applications, and Future Prospects (2020)

Toll-like receptors (TLRs) are the pattern recognition receptors (PRRs) that recognize pathogen-associated molecular patterns (PAMPs) in microbial species. Among the various TLRs, TLR2 has a special place due to its ability to sense the widest repertoire of PAMPs owing to its heterodimerization with either TLR1 or TLR6, broadening its ligand diversity against pathogens. Various scaffolds are reported to activate TLR2, which include naturally occurring lipoproteins, synthetic lipopeptides, and small heterocyclic molecules. We described a detailed SAR in TLR2 agonistic scaffolds and also covered the design and chemistry for the conjugation of TLR2 agonists to antigens, carbohydrates, polymers, and fluorophores. The approaches involved in delivery of TLR2 agonists such as lipidation of antigen, conjugation to polymers, phosphonic acids, and other linkers to achieve surface adsorption, liposomal formulation, and encapsulating nanoparticles are elaborated. The crystal structure analysis and computational modeling are also included with the structural features that facilitate TLR2 activation.
<title>Inspection of high-performance peltier coolers using lock-in thermography</title> (2002)

Peltier cooling devices are used on the Hubble Space telescope for temperature control of various detector packages. A typical construction of these devices involves sandwiching an array of Bismuth-Tellurium (Bi<SUB>2</SUB>Te<SUB>3</SUB>) posts between two ceramic plates. When a DC current is applied to the device heat is moved from one side of the device to the other, depending on the polarity of the current. Because these devices can change temperature very rapidly, there is the potential for damage due to thermal expansion and contraction of the constituents. A failure in the bonding of the Bi<SUB>2</SUB>Te<SUB>3</SUB> to the ceramic sheet can lead to reduced efficiency or failure of the device. NASA Langley Research Center has developed a nondestructive thermal imaging technique to determine the integrity of the Bi<SUB>2</SUB>Te<SUB>3</SUB> posts through the ceramic surface of the peltier device. By driving the peltier device with a time varying DC current, a corresponding temperature rise and fall can be observed on the surface of the device using a commercial infrared camera. Lock-in thermography can then be used to construct both phase and amplitude images of the front surface temperature. It has been found that failure of Bi<SUB>2</SUB>Te<SUB>3</SUB> posts results in a measurable change in both the amplitude and phase. This paper will describe an inspection method that has been developed and show results of the inspection of the extremely small Bi<SUB>2</SUB>Te<SUB>3</SUB> posts whose dimensions are 0.81mm by 0.81mm and approximately 1.45mm tall.
Walking sticks used by the elderly. (1982)

Walking sticks used by the elderlyThe ideal walking stick should be of the correct length and have a ferrule with a good gripping surface and a comfortable handle.1 Many, however, are unsuitable, and some are dangerous.We therefore determined how often walking sticks used by the elderly are faulty.
Microstrip Patch Antenna With Defected Ground Structure for Cross Polarization Suppression (2005)

A defected ground structure (DGS) is proposed to reduce the cross-polarized (XP) radiation of a microstrip patch antenna. The proposed DGS pattern is simple and easy to etch on a commercial microstrip substrate. This will only reduce the XP radiation field without affecting the dominant mode input impedance and co-polarized radiation patterns of a conventional antenna. The new concept has been examined and verified experimentally for a particular DGS pattern employing a circular patch as the radiator. Both simulation and experimental results are presented.
Airborne Haloacetic Acids (2003)

Haloacetic acid (HAA) concentrations were measured in air samples from a semi-rural and a highly urbanized site in southern Ontario throughout 2000 to investigate their sources and gas-particle partitioning behavior. Denuders were efficient for collection of gaseous HAAs, and the particle phase was collected on a downstream quartz filter with negligible breakthrough. Total HAA concentrations (i.e., gas + particles) ranged between <0.025 and 19 ng m(-3) for individual HAAs at both sites. The dominant airborne HAA was monochloroacetic acid (MCA), followed in decreasing order by dichloroacetic acid (DCA), trifluoroacetic acid (TFA), and trichloroacetic acid (TCA). Difluoroacetic acid (DFA), monofluoroacetic acid (MFA), and chlorodifluoroacetic acid (CDFA) were also frequently detected at lower concentrations. Between sites, TFA, DFA, MFA, and TCA concentrations were significantly higher in Toronto, while CDFA concentrations were higher in Guelph. HAAs were primarily in the gas phase all year; however, during colder months, particle-phase HAA concentrations increased relative to the gas phase. Trichloroacetic acid had the highest particle fraction (phi) for all detected HAAs, with a mean phi of 0.51 and 0.56 for Guelph and Toronto, respectively, and both vapor pressure and acid strength appeared to influence gas-particle partitioning. Temporal trends at both sites were partially explained by temperature, short-wave radiation, and particle mass (PM10), leading to indications of the respective sources. A simple deposition model indicated that dry deposition of TFA and TCA should not be neglected in temperate mid-latitude environments and that precipitation concentrations can be successfully predicted by the Henry's law constant.
URLGEN—Toward Automatic URL Generation Using GANs (2022)

URLs play an essential role on the Internet, allowing access to Web resources. Automatically generating URLs is helpful in various tasks, such as application debugging, API testing, and blocklist creation for security applications. Current testing suites deeply embed experts’ domain knowledge to generate suitable URLs, resulting in an ad-hoc solution for each given application. These tools thus require heavy manual intervention, with the expensive coding of rules that are hard to maintain. We here introduce URLGEN, a system that uses Generative Adversarial Networks (GANs) to tackle the automatic URL generation problem. URLGEN is designed for web API testing and generates URL samples for an application without any system expertise, complementing the existing tools. It leverages Long Short-Term Memory (LSTM) and Convolutional Neural Network (CNN) architectures, augmented by an embedding layer that simplifies the URL learning and generation process. We show that URLGEN learns to generate new valid URLs from samples of real URLs without requiring any domain knowledge and following a purely data-driven approach. We compare the GAN architecture of URLGEN against other design options and show that the LSTM architecture can better capture the correlation among URL characters, outperforming previously proposed solutions. Finally, we show that the URLGEN approach can be extended to other scenarios, which we illustrate with two use cases, i.e., cybersquatting domain prediction and URL classification.
Dynamic Elasticity Imaging (2018)

Vibration amplitude sonoelastography entails the application of a continuous low-frequency vibration to excite internal shear waves within the tissue of interest. A real-time vibration image can be created by Doppler detection algorithms. Signal processing estimators were also developed in the study of vibration amplitude sonoelastography. The phase-modulated Doppler spectrum of the signal returned from sinusoidally oscillating objects approximates that of a pure-tone frequency modulation process. A fascinating extension of vibration sonoelastography is the use of an interference pattern formed by two parallel shear wave sources. The crawling waves are visualized by conventional Doppler imaging scanners at typical Doppler frame rates. Crawling waves can also be implemented by a number of techniques including mechanical line sources, surface applicators, or radiation force excitations of parallel beams. Applications of crawling waves include the ex vivo prostate, in vivo muscle, and ex vivo liver.
Urea and Thiourea Adduction of C5—C42-Hydrocarbons (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUrea and Thiourea Adduction of C5—C42-HydrocarbonsRobert W. Schiessler and David FlitterCite this: J. Am. Chem. Soc. 1952, 74, 7, 1720–1723Publication Date (Print):April 1, 1952Publication History Published online1 May 2002Published inissue 1 April 1952https://pubs.acs.org/doi/10.1021/ja01127a033https://doi.org/10.1021/ja01127a033research-articleACS PublicationsRequest reuse permissionsArticle Views305Altmetric-Citations76LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
DNA-based prenatal diagnosis of harlequin ichthyosis with residual ABCA12 expression (2006)

Harlequin ichthyosis (HI) is a devastating genodermatosis that is often fatal during the neonatal period. Until the identifi cation of ABCA12-encoding a keratinocyte lipid transporter, as the causative gene for HI, prenatal diagnosis (PNDx) had been performed for more than 20 years by electron microscopic examination of fetal skin biopsy samples. We report here the fi rst case of DNA-based PNDx for HI. The proband, the fi rst child of healthy non-consanguineous French parents, showed a typical HI phenotype and died soon after birth. ABCA12 immunostaining was markedly reduced in the proband’s skin. Direct sequence analysis of ABCA12 revealed that the proband was a compound heterozygote for two novel mutations: a maternal nonsense mutation p.Ser1249X in exon 26 and a paternal missense mutation p.Arg2479Lys occurring at the last codon of exon 50. p.Ser1249X leads to an approximate 52 % truncation of the ABCA12 protein losing both ATP-binding cassette active sites. p.Arg2479Lys involves a highly conserved codon among diverse species in the second ABCA12 ATP-binding cassette. For their third pregnancy, the parents requested PNDx. Direct sequence analysis using fetal genomic DNA from amniotic fl uid cells at 17 weeks of pregnancy revealed that the fetus was a compound heterozygote for both mutations. The fetus was predicted to be affected and the parents requested the pregnancy to be terminated. The aborted fetus showed typical signs of HI. Analysis of ABCA12 transcripts of cultured keratinocytes from the abortus showed the presence of six abnormally spliced products arising from the allele carrying the missense mutation. Four of them lead to premature termination codons while the two others produced deleted proteins missing 21 and 31 amino acids in the second ATP-binding cassette. These results indicated residual expression of ABCA12. The present report paves the way for molecular PNDx of HI in the earlier stages of pregnancy
Natural killer cell‐mediated contact dermatitis‐like reaction induced by treatment with TLR3 ligand poly(I:C) (2023)

This study provides new insights into how poly(I:C) stimulates NK-mediated reactivity to hapten and suggests that liver NK cells may modulate the immune response to non-pathogenic factors during viral infection.
Tyrosinase Biosensor for the Measurement of Wine Polyphenolics (2001)

Polyphenolics are a broad class of compounds present in many fruits, vegetables, and their products, including grapes and wines. Phenolics are important in winemaking as they contribute many sensorial properties to wines and determine the aging potential of red wine. Current measurements involve monitoring colorimetric chemical reductions and can be time-consuming and generate chemical waste. Biosensors are relatively new analytical devices that offer many advantages over current analytical procedures. In this study, a simple tyrosinase-based biosensor was constructed for the measurement of wine polyphenolics. Excellent correlation was shown between the biosensor and the Folin-Ciocalteu assay for simple phenolics and for model and finished wines. Our results show the tyrosinase-based biosensor to be a rapid, simple, and accurate method for measurement of concentration and reduction potential of polyphenolics in wines.
Ensino do Design e da Arte (2020)

A disputa entre Design e Arte é histórica. Consideramos as múltiplas oposições entre Design e Arte como uma espécie de jogo de armar que opera mais com a complementariedade do que com as diferenças. [...]
Revisiting Shock Initiation Modeling of Homogeneous Explosives (2012)

Abstract Shock initiation of homogeneous explosives has been a subject of research since the 1960s, with neat and sensitized nitromethane as the main materials for experiments. A shock initiation model of homogeneous explosives was established in the early 1960s. It involves a thermal explosion event at the shock entrance boundary, which develops into a superdetonation that overtakes the initial shock. In recent years, Sheffield and his group, using accurate experimental tools, were able to observe details of buildup of the superdetonation. There are many papers on modeling shock initiation of heterogeneous explosives, but there are only a few papers on modeling shock initiation of homogeneous explosives. In this article, bulk reaction reactive flow equations are used to model homogeneous shock initiation in an attempt to reproduce experimental data of Sheffield and his group. It was possible to reproduce the main features of the shock initiation process, including thermal explosion, superdetonation, input shock overtake, overdriven detonation after overtake, and the beginning of decay toward Chapman-Jouget (CJ) detonation. The time to overtake (TTO) as function of input pressure was also calculated and compared to the experimental TTO. Keywords: detonationinitiationnitromethanereactive flow