gebhart/patrepeval huggingface dataset:
Serum Lipid and Lipoprotein Levels in Postmenopausal Women: Short-Course Effect of Caigua (1995)

The present study was designed to determine lipid profiles in postmenopausal women, as well as the effect of short-term increasing oral doses of dehydrated natural caigua (Cycladin®) on serum cholesterol levels, low-density lipoprotein (LDL) cholesterol levels, high-density lipoprotein (HDL) cholesterol levels, and triglycerides levels during 12 weeks of treatment. Eighteen premenopausal and twenty-four postmenopausal women were studied. The family and personal histories of dyslipidemia. hypertension, and obesity were similar in pre- and postmenopausal women, as were body weight, body mass index (BMI). waist/hip ratios, and blood pressure. The postmenopausal women were shorter. Postmenopausal women had higher plasma cholesterol levels, higher LDL cholesterol levels, higher triglyceride levels, and lower HDL cholesterol levels than did the premenopausal women. In postmenopausal women, six capsules daily of dehydrated caigua was the study's only dose that effectively reduced total serum cholesterol levels and LDL cholesterol levels and also significantly increased serum HDL cholesterol levels. At the end of 12 weeks of treatment, serum cholesterol levels were 22% below pretreatment values and serum LDL cholesterol was 33% below initial values, whereas serum HDL cholesterol levels increased to >33% of initial values. Daily treatment with four capsules, two capsules, or placebo failed to modify lipid profiles effectively in postmenopausal women. Treatment with six capsules of caigua daily during 12 weeks reduced the rate of hypercholesterolemia from 75% at the beginning of the study to 12.5% at the end of treatment: similarly, it reduced the rate of hyper-LDL cholesterolemia from 75 to 12.5% and hypo-HDL cholesterolemia from 62.5 to 12.5%. Treatment with caigua had no effect on the prevalence of hypertriglyceridemia. We conclude that our patients with menopause had different lipid profiles from those of the premenopausal women. Menopause alters the lipid profile, and treatment with caigua. a natural plant that is administered dehydrated and capsulated, can reverse dyslipidemia in the postmenopausal woman.
The effect of lithium on the progression‐free and overall survival in patients with metastatic differentiated thyroid cancer undergoing radioactive iodine therapy (2018)

The older age is associated with shorter OS, while disease burden affects OS and PFS in patients with metastatic thyroid cancer. The method of preparation for RAI therapy does not affect the outcome.
Mass Spectrometry Methods for Studying Structure and Dynamics of Biological Macromolecules (2013)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTMass Spectrometry Methods for Studying Structure and Dynamics of Biological MacromoleculesLars Konermann*, Siavash Vahidi, and Modupeola A. SowoleView Author Information Department of Chemistry, The University of Western Ontario, London, Ontario, N6A 5B7 Canada*E-mail: [email protected]. Phone: (519) 661-2111 ext. 86313.Cite this: Anal. Chem. 2014, 86, 1, 213–232Publication Date (Web):December 4, 2013Publication History Received3 December 2013Published online10 December 2013Published inissue 7 January 2014https://doi.org/10.1021/ac4039306Copyright © 2013 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views5858Altmetric-Citations108LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (7 MB) Get e-AlertsSUBJECTS:Gases,Ions,Labeling,Nucleic acid structure,Peptides and proteins Get e-Alerts
High resolution algorithms for multidimensional population balance equations (2004)

Abstract Population balance equations have been used to model a wide range of processes including polymerization, crystallization, cloud formation, and cell dynamics. Rather than developing new algorithms specific to population balance equations, it is proposed to adapt the high‐resolution finite volume methods developed for compressible gas dynamics, which have been applied to aerodynamics, astrophysics, detonation waves, and related fields where shock waves occur. High‐resolution algorithms are presented for simulating multidimensional population balance equations with nucleation and size‐dependent growth rates. For sharp distributions, these high‐resolution algorithms can achieve improved numerical accuracy with orders‐of‐magnitude lower computational cost than other finite difference and finite volume algorithms. The algorithms are implemented in the ParticleSolver software package, which is applied to batch and continuous processes with one and multiple internal coordinates. © 2004 American Institute of Chemical Engineers AIChE J, 50: 2738–2749, 2004
Supplemental Figure 2 from Elevated V–ATPase Activity Following PTEN Loss Is Required for Enhanced Oncogenic Signaling in Breast Cancer (2023)

&lt;p&gt;This figure contains bright-field counterparts of LysoTracker images. This figure also contains HER2 immunostaining after PRR knockdown in SKBR3 cells.&lt;/p&gt;
Formation of Cp(CO)(PR3)FeCH(OCH3)C6H5 complexes via PR3 substitution reactions, hydride addition to Cp(CO)(PR3)Fe:C(OCH3)C6H5+, and methoxide addition to Cp(CO)(PR3)Fe:CHC6H5+. Kinetic and thermodynamic diastereoselectivities. Relative reactivities of synclinal and anticlinal iron carbene isomers (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFormation of Cp(CO)(PR3)FeCH(OCH3)C6H5 complexes via PR3 substitution reactions, hydride addition to Cp(CO)(PR3)Fe:C(OCH3)C6H5+, and methoxide addition to Cp(CO)(PR3)Fe:CHC6H5+. Kinetic and thermodynamic diastereoselectivities. Relative reactivities of synclinal and anticlinal iron carbene isomersMaurice Brookhart and Robert C. BuckCite this: J. Am. Chem. Soc. 1989, 111, 2, 559–567Publication Date (Print):January 1, 1989Publication History Published online1 May 2002Published inissue 1 January 1989https://pubs.acs.org/doi/10.1021/ja00184a025https://doi.org/10.1021/ja00184a025research-articleACS PublicationsRequest reuse permissionsArticle Views154Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An intrinsic vulnerability approach to assess an overburden alluvial aquifer exposure to sinkhole-prone area; results from a Central Iran case study (2023)

DRASTIC is a model used to reliably assess the pollution potential of aquifers at global location. Despite various criticisms of this model or its optimization, sometimes the territorial or geological conditions still must rely on this model approach based on its simplicity. The existence of sinkholes in the alluvial aquifer with an underlying karst aquifer is a clear example of the need to change or optimize the DRASTIC model to improve accuracy of prediction. In this study, the DRASTIC model was changed by adding two factors, the distance to a sinkhole and the sinkhole catchment factors. The modified DRASTIC model was then used to evaluate the pollution potential of Abarkouh aquifer in Yazd province, Central Iran. The intrinsic vulnerability index of Abarkouh aquifer was calculated by the weighted sum method in GIS. The resulting numerical values ranged between 62 and 176 for full study area. Without adding the two layers related to Sin-DRASTIC, the generic DRASTIC Index map showed summed values ranging between 54 and 130. The final Sin-DRASTIC map was divided it into 4 orders very low (<106; 722 km2, 78%), low (107-133; 186 km2, 20%), low to moderate (133-160; 15.3 km2, 1.7%), and moderate vulnerability (161-176; 1.7 km2, 0.3%) vulnerability. Both of the created maps showed high Area Under the Curve values at 76% and 78% for the generic DRASTIC and Sin-DRASTIC respectively. However, the area of the aquifer containing the sinkholes showed low and very low zones of contamination vulnerability on the generic DRASTIC map. The sensitivity analysis showed that the aquifer vulnerability to pollution is mainly controlled by the vadose zone impacts and the sinkhole catchment factor. Therefore, it is concluded that for geologic settings containing sinkholes that are open or contain higher vertical hydraulic conductivity sediment compared to the general matrix of the unconfined aquifer, the Sin-DRASTIC model method yields a superior prediction.
The regulated long-term delivery of therapeutic proteins by using antigen-specific B lymphocytes (2004)

Memory lymphocytes are important mediators of the immune response. These cells are long-lived and undergo clonal expansion upon reexposure to specific antigen, differentiating into effector cells that secrete Ig or cytokines while maintaining a residual pool of memory T and B lymphocytes. Here, the ability of antigen-specific lymphocytes to undergo repeated cycles of antigen-driven clonal expansion and contraction is exploited in a therapeutic protocol aimed at regulating protein delivery. The principle of this strategy is to introduce genes encoding proteins of therapeutic interest into a small number of antigen-specific B lymphocytes. Output of therapeutic protein can then be regulated in vivo by manipulating the size of the responder population by antigen challenge. To evaluate whether such an approach is feasible, we developed a mouse model system in which Emu- and Iglambda-based vectors were used to express human erythropoietin (hEPO) gene in B lymphocytes. These mice were then immunized with the model antigen phycoerythrin (PE), and immune splenocytes (or purified PE-specific B lymphocytes) were adoptively transferred to normal or mutant (EPO-deficient) hosts. High levels of hEPO were detected in the serum of adoptively transferred normal mice after PE administration, and this responsiveness was maintained for several months. Similarly, in EPO-deficient anemic recipients, antigen-driven hEPO expression was shown to restore hematocrit levels to normal. These results show that antigen-mediated regulation of memory lymphocytes can be used as a strategy for delivering therapeutic proteins in vivo.
The role of a peripheral dopamine-antagonist (Motilium) in improving the tolerance to steroidal and non-steroidal anti-inflammatory agents. (1990)

Domperidone protective therapy has been applied in 50 patients suffering from locomotor disease, who responded with dyspeptic complaints to the steroidal and non-steroidal antiphlogistic therapies which meant a risk of the activation of an earlier gastro-intestinal disease. The basic therapy could be applied to 80% of patients due to the Motilium protection because of the favourable changes in gastro-intestinal symptoms. Since domperidone is well tolerated by the patients and it does not yield higher risks, it's use is highly recommended as a protective therapy as well.
Coherent beam combining of collimated fiber array based on target-in-the-loop technique (2011)

Coherent beam combining (CBC) of fiber array is a promising way to generate high power and high quality laser beams. Target-in-the-loop (TIL) technique might be an effective way to ensure atmosphere propagation compensation without wavefront sensors. In this paper, we present very recent research work about CBC of collimated fiber array using TIL technique at the Key Lab on Adaptive Optics (KLAO), CAS. A novel Adaptive Fiber Optics Collimator (AFOC) composed of phase-locking module and tip/tilt control module was developed. CBC experimental setup of three-element fiber array was established. Feedback control is realized using stochastic parallel gradient descent (SPGD) algorithm. The CBC based on TIL with piston and tip/tilt correction simultaneously is demonstrated. And the beam pointing to locate or sweep position of combined spot on target was achieved through TIL technique too. The goal of our work is achieve multi-element CBC for long-distance transmission in atmosphere.
Advances in covalent kinase inhibitors (2020)

Over the past decade, covalent kinase inhibitors (CKI) have seen a resurgence in drug discovery. Covalency affords a unique set of advantages as well as challenges relative to their non-covalent counterpart. After reversible protein target recognition and binding, covalent inhibitors irreversibly modify a proximal nucleophilic residue on the protein via reaction with an electrophile. To date, the acrylamide group remains the predominantly employed electrophile in CKI development, with its incorporation in the majority of clinical candidates and FDA approved covalent therapies. Nonetheless, in recent years considerable efforts have ensued to characterize alternative electrophiles that exhibit irreversible or reversibly covalent binding mechanisms towards cysteine thiols and other amino acids. This review article provides a comprehensive overview of CKIs reported in the literature over a decade period, 2007-2018. Emphasis is placed on the rationale behind warhead choice, optimization approach, and inhibitor design. Current FDA approved CKIs are also highlighted, in addition to a detailed analysis of the common trends and themes observed within the listed data set.
Effects of Cd-free buffer layer for CuInSe/sub 2/ thin-film solar cells (2002)

A ZnO buffer layer by a chemical-bath deposition (CBD) method is developed in this study to improve the interface quality between the n-ZnO window layer and p-CuInSe/sub 2/ (CIS) thin-film absorber in CIS thin-film solar cells as one of the approaches to the fabrication of Cd-free thin-film solar cells. The optimization of the fabrication conditions of CBD-ZnO leads to an efficiency of about 10%. These results indicate that the CBD-ZnO buffer layer has a rather high capability to fabricate high-efficiency CIS thin-film solar cells.
ChemInform Abstract: An Improved Procedure for the Preparation of Aryl‐ and Hetarylacetylenes. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
5-GHz Low Power Current-Reused Balanced CMOS Differential Armstrong VCOs (2007)

This letter proposes 5-GHz low power differential Armstrong voltage controlled oscillators (VCOs) based on balanced topology. One designed VCO uses two single-ended Armstrong VCOs coupled to each other in parallel by balanced structure. The other current-reused VCO uses two single-ended Armstrong VCOs stacked in series. The former VCO oscillates from 4.96 to 5.34GHz and the power consumption is 3.9mW at 0.6-V supply voltage. The latter operates from 4.98 to 5.45GHz and dissipates 2.59mW at 1.8-V supply voltage. The measured phase noises are about -116.71dBc/Hz and -110.02dBc/Hz at 1-MHz offset frequency from 5.1-GHz band, respectively. The former and the latter VCO have an advantage of low power consumption and provide a good figure of merit of about -185dBc/Hz and -180dBc/Hz, respectively
IEEE 802.11 AD HOC Networks: Protocols, Performance, and Open Issues (2004)

The aim of this chapter is triple: an in-depth investigation of the ad hoc features of the IEEE 802.11 standard; an analysis of the performance of 802.11-based ad hoc networks; and an investigation of the major problems arising when using the 802.11 technology for ad hoc networks, and possible directions for enhancing this technology for a better support of the ad hoc networking paradigm. We briefly describe the architecture and protocols of IEEE 802.11 WLANs and later introduce the terminology and present the concepts that are relevant throughout the chapter.
Seismic Refraction Interpretation Using Finite Difference Method (2005)

Correct interpretations of seismic refraction profiles are contingent upon accurate processing, especially in problematic sites where hidden layers may be present. It is found that the Generalized Reciprocal Method (GRM), which is used to solve hidden layer problems, does not give accurate results in some areas without additional modification to the processing flow. To improve the final GRM‐derived velocity‐depth (V‐D) model, the Finite Difference (FD) method is employed to calculate the first arrival's direct and refracted times for any velocity medium. This newly‐developed FD technique is then used to improve the initial GRM‐derived V‐D model. Three synthetic seismic data sets are used to validate this technique, each processed by GRM‐only and FD modified GRM. In each case, the FD modifications are found to provide more accurate results in comparison to those from GRM‐only processing flows.
Randomized decentralized &#x201C;good neighbor&#x201D; DSA based on adaptive antenna array interference mitigation diversity (2010)

Decentralized dynamic spectrum allocation (DSA) that exploit adaptive antenna array interference mitigation (IM) diversity at the receiver, is addressed in interference-limited environment with high level of frequency reuse. The system consists of base stations (BSs) that may belong to different providers in license-exempt spectrum, who can optimize uplink frequency allocation to their subscriber stations (SSs) to achieve the least impact of IM on the useful signal, assuming no control over band allocation of other BSs sharing the same bands. A randomized version of the recently proposed “good neighbor” IM-based DSA strategy is introduced. A possibility of significant reduction of the non-convergence probability at the cost of some controllable degradation of the convergence rate is demonstrated by means of Markov chain analysis and simulations.
A quantitative analysis of histone methylation and acetylation isoforms from their deuteroacetylated derivatives: application to a series of knockout mutants (2013)

The core histones, H2A, H2B, H3 and H4, undergo post-translational modifications (PTMs) including lysine acetylation, methylation and ubiquitylation, arginine methylation and serine phosphorylation. Lysine residues may be mono-, di- and trimethylated, the latter resulting in an addition of mass to the protein that differs from acetylation by only 0.03639 Da, but that can be distinguished either on high-performance mass spectrometers with sufficient mass accuracy and mass resolution or via retention times. Here we describe the use of chemical derivatization to quantify methylated and acetylated histone isoforms by forming deuteroacetylated histone derivatives prior to tryptic digestion and bottom-up liquid chromatography-mass spectrometric analysis. The deuteroacetylation of unmodified or mono-methylated lysine residues produces a chemically identical set of tryptic peptides when comparing the unmodified and modified versions of a protein, making it possible to directly quantify lysine acetylation. In this work, the deuteroacetylation technique is used to examine a single histone H3 peptide with methyl and acetyl modifications at different lysine residues and to quantify the relative abundance of each modification in different deacetylase and methylase knockout yeast strains. This application demonstrates the use of the deuteroacetylation technique to characterize modification 'cross-talk' by correlating different PTMs on the same histone tail.
Rk-means: Fast Clustering for Relational Data (2019)

Conventional machine learning algorithms cannot be applied until a data matrix is available to process. When the data matrix needs to be obtained from a relational database via a feature extraction query, the computation cost can be prohibitive, as the data matrix may be (much) larger than the total input relation size. This paper introduces Rk-means, or relational k -means algorithm, for clustering relational data tuples without having to access the full data matrix. As such, we avoid having to run the expensive feature extraction query and storing its output. Our algorithm leverages the underlying structures in relational data. It involves construction of a small {\it grid coreset} of the data matrix for subsequent cluster construction. This gives a constant approximation for the k -means objective, while having asymptotic runtime improvements over standard approaches of first running the database query and then clustering. Empirical results show orders-of-magnitude speedup, and Rk-means can run faster on the database than even just computing the data matrix.
Analysis of the relationship between available information and performance in facility logistics (2009)

Regarding the amount of processed information, there are two basic approaches to handle today’s increasing requirements for facility logistics systems. First, the collection of all achievable information about the system and its load in order to predict future system states accurately; theoretically, this could lead to optimal results. Second, the use of rather simple heuristics with less need for information but higher flexibility and robustness instead. This approach is for instance being realized with the Internet of Things in facility logistics. This paper analyses the dependency of throughput time and capacity utilization on available information for two limiting cases. While a ‘best possible’ case assumes that the material flow control has all relevant information about the system and loads, a ‘worst reasonable’ case considers the same for very limited information. The influence of layout, throughput, and element availabilities on this relationship is analyzed for both cases on the basis of a scalable generic test system and steady flow situations. In total, nine simulation studies are conducted and analyzed regarding throughput time and element utilization as performance indicators. Implications for the importance of information on performance depending on system complexity are discussed, and directions for further research are provided.
Malignant cell arrest in thymus and spleen of mice bearing transplanted tumors. (1981)

The relationship between the local outgrowth of different subcutaneous transplantable tumors (plasmacytoma MOPC-315, mastocytoma P-815; Lewis lung carcinoma-3LL; fibrosarcoma; lymphomas and mammary adenocarcinoma) and tumor cell spread in different organs was evaluated. The presence of tumor cells in thymus, spleen, lung, and liver was demonstrated by using both in vivo and in vitro methods. Sequestration of tumor cells derived from the transplanted solid tumor was indicated within 3 to 7 days after tumor graft, shortly before or after early palpable outgrowth of the primary tumor was observed. Tumor cells present in thymus and spleen might affect immune responses of tumor-bearing mice.