gebhart/patrepeval huggingface dataset:
Specific binding of the human monocytic cell line U937 to the alternatively spliced connecting segment (IIICS) of fibronectin. (1990)

U937 cells attach to the RGDS-containing 80-kD fragment of fibronectin (Fn). The present report examined whether these cells recognize other domains of Fn. U937 cells attach to a 38-kD fragment derived from the A chain of Fn, which includes the Hep II domain and most of the alternatively spliced IIICS region. U937 did not bind to a 58-kD fragment derived from the B chain (which lacks IIICS) and has the Hep II site. They also did not bind to a 31-kD COOH-terminal fibrin-binding fragment or to a 29-kD fragment containing the Hep I domain. Cell adhesion to the 38-kD fragment was not inhibited by the 80-kD fragment, by GRGDSPC synthetic peptides, or by a mAb directed to the RGDS-containing domain of Fn. Attachment was completely inhibited by the 38-kD fragment and by the synthetic peptide CS-1, comprising the first 25 amino acid residues of IIICS. These results indicate that U937 cells interact with two sites of Fn, the RGDS-containing region, and the IIICS region.
ChemInform Abstract: MALARIAMITTEL 7. MITT. BIS‐TRIFLUORMETHYL‐ALPHA‐2‐PIPERIDYL‐4‐CHINOLINMETHANOLE (1972)

Abstract Aus den 4‐Chinolonen (Ia)‐(Ie) entstehen mit Phosphoroxybromid die 4‐Bromchinoline (II), die zu (IIIa)‐(IIId) carboxyliert werden.
Experimental high school organic chemistry. (2001)

This project investigated teaching techniques of organic chemistry. A general overview of science and chemistry teaching methods is discussed in this report. This project comprised of designing and testing a hands-on approach to teaching introductory organic chemistry, involving concept-related laboratories. Working with St. Croix Country Day School (CDS), located on St. Croix, US Virgin Islands, this approach was explored with 11th and 12th grade students. We encountered many obstacles in our project. However, it was successful.
Supplementary Data from Targeted Knockdown of <i>Notch1</i> Inhibits Invasion of Human Prostate Cancer Cells Concomitant with Inhibition of Matrix Metalloproteinase-9 and Urokinase Plasminogen Activator (2023)

Supplementary Data from Targeted Knockdown of &lt;i&gt;Notch1&lt;/i&gt; Inhibits Invasion of Human Prostate Cancer Cells Concomitant with Inhibition of Matrix Metalloproteinase-9 and Urokinase Plasminogen Activator
Comparison of ethanol tolerance between potential cyanobacterial production hosts (2018)

Cyanobacteria are photosynthetic prokaryotes that have been extensively studied as potential autotrophic biotechnological hosts for the production of different carbon-based end-products directly from atmospheric CO<sub>2</sub>. While commercially competitive applications do not yet exist, the production of ethanol in cyanobacteria is the most mature technology, endorsed by relatively high production yields and established status of ethanol in the global biofuel market. Within this concept, the aim here was to systematically compare ethanol tolerance of different commonly used cyanobacterial strains and substrains, in order to assess their relative potential for biotechnological production platforms. The comparison revealed clear strain-specific differences in ethanol toxicity, with growth inhibition GI<sub>50</sub> values ranging between 3 g L<sup>-1</sup> (0.4% V/V) and 28 g L<sup>-1</sup> (3.5% V/V). The most tolerant wild-type strains were Synechocystis sp. PCC 6803 (substrain A) and Synechococcus sp. PCC 7002, which did not show any apparent effect in growth below ethanol concentrations 9.2 g L<sup>-1</sup> (1.2% V/V). In comparison to typical biotechnological yeast strains used for ethanol fermentation, these values are clearly lower but still around the same order of magnitude. The results also underlined the challenges in direct number-based comparison between cyanobacterial strains and culture conditions due to inconsistencies in respect to chlorophyll content, cell morphology and optical properties.
Intracommunity relationships, dispersal pattern and paternity success in a wild living community of Bonobos (Pan paniscus) determined from DNA analysis of faecal samples (1999)

Differences in social relationships among community members are often explained by differences in genetic relationships. The current techniques of DNA analysis allow explicit testing of such a hypothesis. Here, we have analysed the genetic relationships for a community of wild bonobos (Pan paniscus) using nuclear and mitochondrial DNA markers extracted from faecal samples. Bonobos show an opportunistic and promiscuous mating behaviour, even with mates from outside the community. Nonetheless, we find that most infants were sired by resident males and that two dominant males together attained the highest paternity success. Intriguingly, the latter males are the sons of high-ranking females, suggesting an important influence of mothers on the paternity success of their sons. The molecular data support previous inferences on female dispersal and male philopatry. We find a total of five different mitochondrial haplotypes among 15 adult females, suggesting a frequent migration of females. Moreover, for most adult and subadult males in the group we find a matching mother, while this is not the case for most females, indicating that these leave the community during adolescence. Our study demonstrates that faecal samples can be a useful source for the determination of kinship in a whole community.
A photographic technique for quick assessment of mechanical isocenter of a linear accelerator (2017)

Demands for mechanical accuracy of medical linear accelerators are increased due to the stereotactic and modulated rotational treatments. Mechanical inaccuracies affect the size and shape of the mechanical and radiation isocenters. In practice, the mechanical isocenter is defined by the intersection of rotational axes. However, there are no simple tools to check the properties of the mechanical isocenter in 3D. We introduce a new photography-based method for quick and sub-millimeter accurate determination of the mechanical isocenter. The method is based on image-processing algorithm and modified front pointer. The results demonstrate the quick measurement and visualization of the mechanical isocenter.
Narrow linewidth, high-power Al-free active region (λ = 852nm) DFB laser diodes for atomic clocks and interferometry applications (2007)

Single frequency and single spatial mode diode lasers emitting at 852nm are strategic components for systems such as atomic clocks (positioning systems for navigation, in space atomic clock like Galileo or Pharao (cold atom), measurement of fundamental constants), or interferometry applications. We have developed the technological foundations of lasers at 852nm to address these different applications. These include an Al free active region, a single spatial mode ridge waveguide and a DFB (distributed feedback) structure. The device is a separate confinement heterostructure with a GaInP large optical cavity and a single compressive strained GaInAsP quantum well. For an AR-HR coated ridge Fabry Perot laser, we obtain a power of 230mW with M<sup>2</sup>=1.3. An optical power of 150mW was obtained at 854nm, 20°C for AR-HR coated devices. We obtain a single spatial mode emission and a SMSR over 50dB, both at 150mW. DFB Lasers at 852.12nm, corresponding to the D2 caesium transition, were then realised with a power of 40mW per facet, 37°C for uncoated devices. At 40mW, we determine a M<sup>2</sup> value of 1.3. We measure a SMSR value around 50dB between 10°C and 80°C. On this last laser run, we obtain very homogeneous spectral linewidth values for five different lasers, measured with a Fabry Perot interferometer. We obtain at 20°C a low average linewidth value of 1.40MHz and 1.10MHz at respectively 40mW and 20mW, together with a low standard deviation of 0.1MHz. At 852.12nm (37°C, 40mW), a low linewidth value of 1MHz was measured, for one laser preliminary tested.
Cardiovascular risk remains high in schizophrenia with modest improvements in bipolar disorder during past decade (2019)

Despite major advances in health promotion during the past decade, there has been no reduction in the level of CVD risk factors in patients with SCZ and modest improvement in BD.
Mostly accurate stack scanning (2001)

Permission is granted for noncommercial reproduction of the work for educational or research purposes.
Profiling: A functional aid to effective communication (1983)

Profiling is an aspect of audience analysis that enables a communicator to develop a strategy of communication along several dimensions. This paper describes a systematic approach to profiling, using an interesting “slice of life” to illustrate the point. With certain modifications, similar approaches can be devised by the reader for virtually any situation presenting a need to communicate.
Highly Efficient Modification of Bacterial Artificial Chromosomes (BACs) Using Novel Shuttle Vectors Containing the R6Kγ Origin of Replication (2002)

Bacterial artificial chromosome (BAC) mediated transgenesis has proven to be a highly reliable way to obtain accurate transgene expression for in vivo studies of gene expression and function. A rate-limiting step in use of this technology to characterize large numbers of genes has been the process with which BACs can be modified by homologous recombination in Escherichia coli. We report here a highly efficient method for modifying BACs by using a novel set of shuttle vectors that contain the R6Kgamma origin for DNA replication, the E. coli RecA gene for recombination, and the SacB gene for negative selection. These new vectors greatly increased the ease with which one can clone the shuttle vectors, as well as screen for co-integrated and resolved clones. Furthermore, we simplify the shuttle vector cloning to one step by incorporation of a "built-in" resolution cassette for rapid removal of the unwanted vector sequences. This new system has been used to modify a dozen BACs. It is well suited for efficient production of modified BACs for use in a variety of in vivo studies.
Authoring interactive multimedia: problems and prospects (1994)

Bipolar disorder is associated with an inflammation-triggered elevated catabolism of tryptophan to the kynurenine pathway, which impacts psychiatric symptoms and outcomes. The data indicate that lithium exerts anti-inflammatory effects by inhibiting indoleamine-2,3-dioxygenase (IDO)-1 activity. This exploratory study aimed to investigate the tryptophan catabolism in individuals with bipolar disorder (<i>n</i> = 48) compared to healthy controls (<i>n</i> = 48), and the associations with the response to mood stabilizers such as lithium, valproate, or lamotrigine rated with the Retrospective Assessment of the Lithium Response Phenotype Scale (or the Alda scale). The results demonstrate an association of a poorer response to lithium with higher levels of kynurenine, kynurenine/tryptophan ratio as a proxy for IDO-1 activity, as well as quinolinic acid, which, overall, indicates a pro-inflammatory state with a higher degradation of tryptophan towards the neurotoxic branch. The treatment response to valproate and lamotrigine was not associated with the levels of the tryptophan metabolites. These findings support the anti-inflammatory properties of lithium. Furthermore, since quinolinic acid has neurotoxic features via the glutamatergic pathway, they also strengthen the assumption that the clinical drug response might be associated with biochemical processes. The relationship between the lithium response and the measurements of the tryptophan to the kynurenine pathway is of clinical relevance and may potentially bring advantages towards a personalized medicine approach to bipolar disorder that allows for the selection of the most effective mood-stabilizing drug.
Pairing Mathematical Morphology with Artificial Color to Extract Targets from Clutter (2007)

In numerous prior works, a technique called Artificial Color has been developed to extract pixels belonging to a prespecified class while rejecting pixels belonging to other prespecified sets with great reliability. The heart of the algorithm is another well described pattern recognition method called Margin Setting. Margin Setting achieves highly reliable classification by refusing to classify some borderline pixels. As a result, the image produced using Artificial Color methods is reliable in finding the target of interest but that target may contain unclassified pixels, leading to a spotty or ragged image being extracted. It is showed here that post processing that ragged image using mathematical morphology can improve the extracted image substantially, and median filtering after that produces even more improvement.
Concerted Growth and Ordering of Cobalt Nanorod Arrays as Revealed by Tandem in Situ SAXS-XAS Studies (2016)

The molecular and ensemble dynamics for the growth of hierarchical supercrystals of cobalt nanorods have been studied by in situ tandem X-ray absorption spectroscopy-small-angle X-ray scattering (XAS-SAXS). The supercrystals were obtained by reducing a Co(II) precursor under H2 in the presence of a long-chain amine and a long-chain carboxylic acid. Complementary time-dependent ex situ TEM studies were also performed. The experimental data provide critical insights into the nanorod growth mechanism and unequivocal evidence for a concerted growth-organization process. Nanorod formation involves cobalt nucleation, a fast atom-by-atom anisotropic growth, and a slower oriented attachment process that continues well after cobalt reduction is complete. Smectic-like ordering of the nanorods appears very early in the process, as soon as nanoparticle elongation appears, and nanorod growth takes place inside organized superlattices, which can be regarded as mesocrystals.
Effect of Follow‐Up Intervention of Toothbrushing on Periodontal Health in Workplace Dental Examination (2004)

This study examined the effect of follow-up intervention on periodontal health of workers on the basis of clinical assessment and a laboratory test. Toothbrushing instruction was given to 26 workers (41.4 +/- 7.8 yr of age). In the experimental group (EG), 13 workers received re-instruction and reminder messages after the initial intervention. The remaining 13 workers, who served as a control group (CG), underwent no follow-up. Brushing skill was assessed on the basis of plaque scores for the whole mouth (Plaque Control Record, PCR) and for eight representative teeth (Plaque Index, PLI). Periodontal health was evaluated with the Community Periodontal Index (CPI). Assessment of gingival inflammation (Modified Gingival Index, MGI), measurements of pocket depth (PD) and attachment level (AL), and collection of gingival crevicular fluid (GCF) were performed at the representative sites. Aspartate aminotransferase (AST) in GCF was determined. Periodontal assessments were conducted prior to and three months after the first examination. Data were analyzed on site- and subject-bases. Both groups exhibited a significant reduction in PLI and MGI. PCR and PD significantly decreased exclusively in the EG. No significant change was observed in the CPI or AL. A significant reduction in PD in shallow pockets (PD<=3 mm) and declines in AL and AST in deeper pockets (PD>=4 mm) were detected in EG. A reduction in PD in deeper pockets was significant in the CG. These results indicate that intervention with follow-up is more effective with respect to periodontal health of workers than is a single intervention; moreover, the laboratory GCF test could be employed to ascertain the outcome of behavioral change.
Mesenteric Adipose-derived Stromal Cells From Crohn’s Disease Patients Induce Protective Effects in Colonic Epithelial Cells and Mice With Colitis (2018)

Mesenteric adipose tissue hyperplasia is a hallmark of Crohn's disease (CD). Recently, we showed that mesenteric adipose-derived stromal cells (ADSCs) from CD, ulcerative colitis, and control patients synthesize and release adipokines in a disease-dependent manner. Here we examined the expression profiles of CD and control patient-derived mesenteric ADSCs and studied the effects of their extracellular mediators on colonocyte signaling in vitro and experimental colitis in vivo. ADSCs were isolated from mesenteric fat of control and CD patients. Microarray profiling and network analysis were performed in ADSCs and human colonocytes treated with conditioned media from cultured ADSCs. Mice with acute colitis received daily injections of conditioned media from patient-derived ADSCs, vehicle, or apolactoferrin. Proliferative responses were evaluated in conditioned media-treated colonocytes and mouse colonic epithelium. Total protein was isolated from cultured colonocytes after treatment with apolactoferrin for Western blot analysis of phosphorylated intracellular signaling kinases. Microarray profiling revealed differential mRNA expression in CD patient-derived ADSCs compared with controls, including lactoferrin. Administration of CD patient-derived medium or apolactoferrin increased colonocyte proliferation compared with controls. Conditioned media from CD patient-derived ADSCs or apolactoferrin attenuated colitis severity in mice and enhanced colonocyte proliferation in vivo. ADSCs from control and CD patients show disease-dependent inflammatory responses and alter colonic epithelial cell signaling in vitro and in vivo. Furthermore, we demonstrate lactoferrin production by adipose tissue, specifically mesenteric ADSCs. We suggest that mesenteric ADSC-derived lactoferrin may mediate protective effects and participate in the pathophysiology of CD by promoting colonocyte proliferation and the resolution of inflammation.
A Study on the Relevance Improvement of Enterprise Search using Tag Information (2010)

기업에서 업무 시스템들을 활용하여 업무를 진행하다 보면 기하급수적으로 증가하는 정보를 얼마나 신속하고 정확하게 사용자에게 제공할 수 있는가 하는 것이 기업 경쟁력의 중요한 요소이다. 검색 적합성 향상을 통한 양질의 검색 결과 제공은 기업 경쟁력의 중요한 요소가 되었으며, 가치 있고 효율적인 검색 서비스 제공을 위해 검색엔진에서 제공하는 단순한 검색 서비스 이상을 제공하는 것이 필요하다. 본 논문에서는 검색 과정에서 Tag 정보와 그 가중치 값을 활용하여 검색 적합성을 향상 시키는 방안에 대해서 연구함으로써 검색엔진에서 제공하는 검색 적합성의 한계를 극복하는 방안을 제안한다. 또한, 제안된 방법에 대한 검색 성능을 비교하기 위해서 제안 기법을 기존 웹 검색 서비스에서 제공하는 검색결과와의 적합성 평가 및 연관 검색어와 비교함으로써 우수성을 검증하였다. In this paper, how fast and accurate the companies provides exponentially increasing information to the users is the most important in the corporate competitiveness. The enhancement of the retrieval relevance became the important element in enhancing company competitiveness and it is required to provide the services that are beyond simple retrieval service for good quality search service. This paper proposes the effective scheme that enhances retrieval relevance by utilizing registered tag information. By proposed scheme, we can overcome the limitations of retrieval relevance that usual search engines provide. And we compare the proposed scheme with existing web retrieval service on retrieval relevance evaluation and related search keyword.
Evolution of the Lamellar Structure during Crystallization of a Semicrystalline-Amorphous Polymer Blend: Time-Resolved Hot-Stage SPM Study (2000)

The mechanisms of polymer crystallization at the nanometer scale have been investigated with a hot-stage scanning probe microscope (SPM). The processes of lamellar perfection, e.g., lamellar thickening and merging of lamellar fragments, are revealed during the secondary crystallization stage. It is shown that the information contained in SPM images can be comparable to that of time-resolved small-angle x-ray scattering (SAXS). In addition, SPM opens the way to examine subtle structural changes that would certainly be overlooked in the global morphological parameters obtained from a simple SAXS correlation function analysis.
Dendronized Polymers: Synthesis, Characterization, Assembly at Interfaces, and Manipulation (2000)

Dendrimers are presently one of the most intensely studied classes of compounds because of their unusual structure. They can be described as a jungle of entangled branches traversed by winding trails which lead to sweet fruits and bright blossoms. On these trails one can reach the thicket's interior as well as find a way out. Expressed less lyrically, this thicket stands for regularly branched, densely packed structures, and the trails represent voids and channels not filled by bent back branches but by solvent. The fruit and blossoms are photochemically, electrochemically, or synthetically addressable units, catalytically active sites, etc., and the back and forth on the trails stands for transport processes. In a mathematical sense dendrimers are enveloped by an interface, which defines what is either in or out. This interface is shaped like a sphere if the trails are filled to bursting. Otherwise dendrimers are more flattened like amoeba, especially if in contact with a surface. The high density of the functional groups, the expansion of these compounds to a range of several nanometers, the existence of usable "surface" and transport possibilities in and with them have made dendrimers interesting candidates for many applications. This review describes how dendrimer construction and polymer synthesis were combined and used to move from fully or flattened spherical shapes to cylindrical ones. The shape-inducing influence of dendritic substituents can be driven to create nanoobjects with a cylindrical shape, which not only considerably widens the range of applications for the dendrimer class but also opens up new perspectives for supramolecular and polymer chemistry. Because of the sheer size of the described objects and complexity of shape-related properties, research in this area must necessarily be interdisciplinary. This article tries to mirror this by giving special attention not only to synthesis but also the characterization and behavior of these compounds in bulk and at interfaces. Furthermore, potential application fields are described.
Design of vehicle lateral guidance system for driver assistance (2000)

Guidance information is significant to the driver during manual steering of a vehicle. With difficulty in perceiving the environment (e.g. in dense fog or white-out conditions), the driver may encounter problems of handling the vehicle safely. A supplementary guidance display, which includes the road information, the future vehicle position, and the current vehicle position, can provide the preview information to the driver. Two display laws for predicting the future position of the vehicle have been studied in previous research. The kinematic display law with simple formulation is suitable for low vehicle speeds, while the nonlinear gain-scheduled display law can be applied to a wide range of vehicle speeds. With the assistance of the lateral guidance system, the driver may act as a simple proportional controller to safely steer the vehicle. The results of closed-loop simulation show the advantage of the guidance display. The human-in-the-loop steering simulator is used to further validate the effectiveness of the lateral guidance system for driver assistance.
United States Foreign Policy toward Africa: An Afro-American Perspective (1972)

The importance of Africa in contemporary world affairs and the responsibilities of the U.S. as the major power in the “free world” have contributed to a re-examination of American foreign policy towards Africa. Attempts to clearly identify U.S. interests in Africa reflect the desire of the present Administration to avoid unnecessary involvement in African affairs that might parallel America’s Southeast Asia experience. In addition, identification of vital interests ought to permit the formulation and implementation of better (if not ideal) American policies. Recognizing the linkages between domestic and foreign policies, it is proper that one include as part of the process of foreign policy formulation the perspectives and interests of significant groups within American society. Thus, the examination of Afro-American views on U.S. foreign policy towards Africa becomes an important area of concern.