gebhart/patrepeval huggingface dataset:
Perfil de puérperas submetidas a métodos de reprodução assistida [Profile of postpartum women submitted to assisted reproduction methods] [Perfil de puérperas sometidas a métodos de reproducción asistida] (2012)

Estudo cujo objetivo foi discutir o perfil de mulheres submetidas a métodos de reprodução assistida em hospital privado do Município de São Paulo, em 2009. Pesquisa quantitativa, descritiva, exploratória, transversal, de nível I. A amostra constituiu-se de 38 puérperas no segundo dia de internação, submetidas a método de reprodução assistida. Para a coleta de dados utilizou-se a entrevista estruturada baseada em formulário específico. As mulheres tinham entre 30 e 39 anos (77%), eram casadas (89%) e 68% eram profissionais da área das ciências humanas. Os métodos mais utilizados foram indução da ovulação (47%) e fecundação in vitro clássica (39%). Engravidaram na primeira tentativa 63% e o tempo entre as tentativas de fertilização e o sucesso variou de um mês e meio a dois anos. O grupo estudado corresponde a uma nova geração de mulheres que, independente da idade e da técnica utilizada, tiveram possibilidade de escolher e planejar uma gestação. ABSTRACT: The study discussed the profile of women submitted to assisted reproduction methods in a private hospital in São Paulo, Brazil, in 2009. It was a Level I, exploratory, descriptive, quantitative, cross-sectional study. The sample was 38 mothers on the second day of hospitalization who had undergone assisted reproduction. Data collection was performed by structured interview based on a specific script. The women were from 30 to 39 years old (77%), married (89%), and professionals in the human sciences (68%). The methods used were ovulation induction (47%) and classical in vitro fertilization (39%); 63% becoming pregnant on the first try, and the interval between attempted and successful fertilization ranging from a month and a half to two years. The group studied represents a new generation of women who, regardless of age and the technique used, had the opportunity to choose and plan a pregnancy. RESUMEN: Estudio cuyo objetivo fue discutir el perfil de mujeres sometidas a métodos de reproducción asistida en hospital privado de São Paulo-Brasil, en 2009. Se trata de investigación cuantitativa, descriptiva, exploratoria, de corte transversal, de nivel I. La muestra estuvo conformada por 38 madres en el segundo día de hospitalización, sometidas a método de reproducción asistida. Para recopilar los datos se utilizó la entrevista estructurada basada en formulario específico. Las mujeres tenían edades entre 30 y 39 años (77%), eran casadas (89%) y 68% eran profesionales de las ciencias humanas. Los métodos utilizados fueron: inducción de la ovulación (47%) y la clásica fertilización in vitro (39%). 63% quedaran embarazadas en el primer intento y el tiempo entre los intentos y el éxito de la fertilización varió de un mes a dos años y medio. El grupo representa una nueva generación de mujeres que, independientemente de la técnica utilizada, pudieron escoger y planear un embarazo.
Transient, meiosis-induced expression of the rec6 and rec12 genes of Schizosaccharomyces pombe. (1994)

Two meiotic recombination genes, rec6 and rec12, from Schizosaccharomyces pombe have been cloned by genetic complementation and their DNA sequences determined. Gene replacements demonstrated that the cloned fragments contained the rec6 and rec12 genes. Further analysis showed that the functional rec6 gene was within a 1.3-kb fragment and rec12 within a 1.7-kb fragment. The nucleotide sequences of these fragments revealed open reading frames (ORFs) predicting 143 amino acids for the rec6 gene product and 139 amino acids for the rec12 gene product. After pat1-114 temperature-induced meiosis, the transcripts of rec6 and rec12 were induced to maximal levels at 2-3 hr, at about the time of premeiotic DNA synthesis, but were present at much lower levels before and after this time. The transient induction of the transcripts and the phenotypes of the mutants suggest that the rec6 and rec12 gene products are involved primarily in the early steps of meiotic recombination in S. pombe. Near the rec6 gene are two additional ORFs potentially encoding proteins with homology to ribosomal protein S7 of Saccharomyces cerevisiae (ORF137) and to the homeodomain of developmental regulatory proteins (ORF201). The roles of these S. pombe ORFs remain to be determined.
Shape Memory Metals / Marie Haı¨dopoulos, Fatiha El Feninat, Diego Mantovani (2008)

Shape Memory Metals (SMM) have certain original properties, particularly an ability to return to a memorized shape in response to a simple change in temperature. The shape-memory effect was ﬁrst observed in copper-zinc and copper-tin alloys by Greninger and Mooradian in 1938, but it was only in the early 1960s that Buehler and his colleagues discovered and patented Nitinol (NIckel TItanium Naval Ordnance Laboratory), a nickel-titanium alloy created in the Naval Ordnance Laboratory. Buehler suggested using SMMs in dentistry to make implants that would return to a pre-set shape. Much work has since been done to exploit the high potential of these materials for biomedical applications. They currently seem to hold the most promise in radiology, cardiovascular applications, urology, and other medical applications for use as prostheses, tissue connectors, and endovascular stents. In fact, SMMs have come into wide use because of their exceptional superelasticity, their shape memory, their good resistance to fatigue and wear, and their relatively good biocompatibility.
Propagation of Errors in Review Articles (2006)

Science has done an excellent job of sensitizing us to issues of fabricated data. Nevertheless, there is a related issue that also deserves discussion: sham publication in the secondary literature. It is important because scientists rely on the authors of reviews to gather and analyze the unwieldy
Encoding cardinality constraints using multiway merge selection networks (2019)

Boolean cardinality constraints (CCs) state that at most (at least, or exactly) k out of n propositional literals can be true. We propose a new, arc-consistent, easy to implement and efficient encoding of CCs based on a new class of selection networks. Several comparator networks have been recently proposed for encoding CCs and experiments have proved their efficiency (Abío et al. 2013, Asín et al. Constraints 12(2): 195–221, 2011, Codish and Zazon-Ivry 2010, Eén and Sörensson Boolean Modeling and Computation 2: 1–26, 2006). In our construction we use the idea of the multiway merge sorting networks by Lee and Batcher (1995) that generalizes the technique of odd-even sorting ones by merging simultaneously more than two subsequences. The new selection network merges 4 subsequences in that way. Based on this construction, we can encode more efficiently comparators in the combine phase of the network: instead of encoding each comparator separately by 3 clauses and 2 additional variables, we propose an encoding scheme that requires 5 clauses and 2 variables on average for each pair of comparators. We also extend the model of comparator networks so that the basic components are not only comparators (2-sorters) but more general m-sorters, for m ∈ {2, 3, 4}, that can also be encoded efficiently. We show that with small overhead (regarding implementation complexity) we can achieve a significant improvement in SAT-solver runtime for many test cases. We prove that the new encoding is competitive to the other state-of-the-art encodings.
Evaporation Temperature Dependence of Particle Size of Sb-Nanoparticles Grown by Absorption Process in the Flowing Gas Evaporation Method (2002)

Antimony nanpoparticles were formed by the flowing gas evaporation method at various evaporation temperatures. The mean particle diameter is smaller than 10 nm and decreases with the increase of evaporation temperature. This phenomenon is discussed based on the absorption growth process. The amount of absorption vapor per unit nucleus decreases with the increase of evaporation temperature. The geometric standard deviation obtained from the size distribution shows a small value compared with the case of evaporation in a closed inert gas.
Two year clinical wear performance of two different polyacid modified resin composites in posterior permanent teeth (2008)

Aim: The aim was to compare the clinical wear of two compomers (F2000; 3M/ESPE and Dyract AP; Dentsply) placed in occlusal cavities in permanent molars within a two-year follow-up period using an indirect method of evaluation. Methods: Twenty-one patients, whose treatment plans included Class I restorations, were selected. Each patient received two occlusal Class I restorations in permanent molars. One and 2 years after placement of the restorations, the 21 teeth restored with each material were submitted to wear evaluation. Polyvinylsiloxane impressions were taken and casts were made (baseline, 1 year and 2 years). The casts were classified by comparative evaluation using sets of 18 calibrated standard models (0 to 900 ??m), according to Leinfelder???s indirect method. Paired and unpaired t-tests were used for comparisons between the evaluations for the same material and between materials for each evaluation period, respectively. Results: The occlusal wear was higher after 2 years than after 1 year (p&lt;0.001). The t-test\ndemonstrated that the wear values, after 1 year, were similar for both compomers (F2000=17.6 ??m and Dyract AP=12.8 ??m).\nHowever, after 2 years, F2000 restorations (40.6 ??m) suffered significantly more wear (p&lt;0.05) than Dyract AP restorations (29.8\n??m). Although compomers performed similarly after 1 year, Dyract showed less occlusal wear after 2 years. All occlusal Class I\ncompomer restorations presented more occlusal wear after 2 years, but were considered as clinically acceptable within the evaluation\nperiod. Conclusions: The mean wear values found for both compomers do not indicate the need for either repair or replacement of\nthe restorations.
Uninterrupted perioperative clopidogrel and bleeding-related events after total joint arthroplasty: a case series. (2015)

There is a known bleeding risk with administration of the antiplatelet drug clopidogrel, but in certain patients the likelihood of thrombosis is too high to cease its administration perioperatively. The risks of performing total joint arthroplasty in this population are unknown. An inpatient pharmacy database query identified seven patients who underwent eight hip or knee arthroplasties from 2007 to 2009 without perioperative interruption in clopidogrel administration. Bleeding-related events were recorded, including one inpatient death, one reoperation for infection, two 30-day readmissions, two antibiotic prescriptions for the incision, and blood transfusion administration during seven of eight admissions. The majority of bleeding-related events occurred following knee arthroplasty. Uninterrupted perioperative clopidogrel administration was associated with a high risk of bleeding-related events following total joint arthroplasty, particularly of the knee. Consideration should be given to delaying total joint arthroplasty until clopidogrel can safely be held in the perioperative period.
Riccati approach to the propagation of axially symmetric waves in a coaxial guide (1968)

The problem of the axially symmetric modes (∂/∂θ = 0) in a coaxial waveguide has been studied afresh in terms of the first-order nonlinear wave equation of Riccati type in which the dependent variable involves the wave impedance EZ/Hθ looking radially across the guide. This presentation is particularly suitable when ε and μ are functions of the radial co-ordinate r, while, for the mode in which Hθw is the only component of magnetic field and the guide is narrow enough to cut off the higher-order modes, the nonlinear term behaves as a small correction, leading to an iterative solution. It is shown that, under some conditions, for instance when there is a dielectric layer on or near to the outer conducting wall, there can be a small decrease in attenuation along the guide below the value for the quasi-TEM mode when there is only air in the guide. This effect, however, depends on the actual radius of the inner conductor and on the ratio of the radii of the outer and inner conductors being sufficiently large, and is, moreover, rapidly offset when the loss factor in the dielectric is increased.
High temperature solution calorimetry. Part II. Thermodynamic investigation of the systems: AgCl–KCl, AgCl–RbCl, AgCl–CsCl (1967)

The thermal properties of the binary systems AgCl–KCl, AgCl–RbCl, and AgCl–CsCl have been investigated over the entire composition range and in the temperature range 660 to 860 °C. From the combined results of the calorimetric investigation and the measured phase diagrams of the binary systems, activities and other partial molar properties have been calculated.
Power losses in induction machines (1935)

Discussion and authors' closure of a paper by P. M. Narbutovskih published in the November 1934 issue, pages 1466–71, and presented for oral discussion at the induction motor session of the winter convention, New York, N. Y., January 24, 1935.
First Experimental Evidence of an Intramolecular H Bond between Aliphatic Cl and Aromatic C–H (2011)

The first example of an intramolecular H bond between aliphatic Cl and aromatic C–H was observed in the crystal of C2-symmetric (4R,5R)-4,5-bis(diphenylchloromethyl)-1,3,2-dioxathiolane 2-oxide. In this case one Cl atom is engaged in H-bonding with two ortho-C–H groups in the axial and equatorial phenyl planes, with the recorded distances of 2.562 Ǻ and 2.804 Ǻ, respectively. The observed angle for Ca–H–Cl is 108.41° and that for Cq–H–Cl is 96.53°.
846 Pre-clinical validation of a FLT3L-fusion protein for dendritic cell expansion and anti-tumor efficacy (2021)

<h3>Background</h3> The ligand for the receptor tyrosine kinase FMS-like tyrosine kinase 3 (FLT3) plays an importantrole in hematopoiesis. FLT3 signaling is required for the differentiation andexpansion of dendritic cells. In the context of cancer immunity, the conventional dendritic cellsubtype 1 (cDC1) are required for the generation of tumor-specific T cell responses in mousepreclinical models. In human tumors cDC1 are often underrepresented in thetumor microenvironment, supporting the hypothesis that therapeutically increasing their number via FLT3 pathway stimulation has the potential to promote T cell-mediated anti-tumor efficacy. <h3>Methods</h3> GS-3583 is a fusion protein composed of the extracellular domain (ECD) of human FLT3 ligand(FLT3L) combined with a modified fragment crystallizable (Fc) region of human IgG4. GS-3583was designed to induce cDC1 expansion and subsequently promote tumor-reactive T cell priming, activation and recruitment into the tumor microenvironment. To evaluate the therapeutic efficacy of FLT3 stimulation in vivo, a mouse surrogate mGS-3583was designed using the ECD of mouse FLT3L fused to an engineered mouse IgG2a Fc withattenuated binding to mouse FcgRs. Results mGS-3583 bound to recombinant mouse FLT3 with an estimated affinity of 15 nM, and to mouse FLT3-expressing cells with an EC50 of 0.15 nM. In vivo, mGS-3583 showed single agent dose-dependent tumor growth inhibition (TGI) in tumors that correlated with peripheral and intratumoral cDC1 expansion. In tumors with no initial immune infiltration, mGS-3583 led to an influx of T cells into the tumors. In addition to single agent efficacy, mGS-3583 combined effectively with programmed cell death protein (ligand)-1 (PD(L)-1) pathway blockade. <h3>Conclusions</h3> In vivo expansion of dendritic cells can convert uninflamed (cold) tumors to immunologically active (hot) tumors and initiate productive anti-tumor immune responses. These findings support the development GS-3583 as a promising candidate for cancer immunotherapy.
Development of a scientific method for classification of facial skin types. (1985)

There is great variation in the nature and quality of facial skin in women. In the cosmetics industry, these variations in skin type have been classified subjectively as either oily, normal, or dry. Several physiological parameters of the skin were measured in an attempt to develop a scientific method for classifying skin types. Eighty women (age 20 to 59) participated in this one year study. Each was administered a skin type self-estimation questionnaire six times and answered puestions about the nature of their own skin. Parameters such as skin surface lipid quantity, transepideramal water loss (TWL), skin surface morphology, conversion rate of glutamic acid to pyrrolidone carboxylic acid (PCA%) were measured at the same time the self-estimation questionnaires ware given.It was found that skin type is classified subjectively based on the independent sensations of “dryness” and “oiliness”. The former corresponded to TWL, skin surface morphology, and PCA% and the latter to skin surface lipid. The conventional skin classification procedure depends mainly on the level of skin surface lipids. This paper confirmed the existence of other parameters related to dryness.Previous studies by the authors revealed that surface morphology reflected the biochemical events of keratinization, such as free amino acid metabolism including the glutamic acid to pyrrolidone carboxylic acid conversion rate, and also had a close relationship with TWL showing water barrier function and skin surface conductance indicating the water content of the stratum corneum. Thus, these parameters were found to be a valuable index for the water holding capacity of the skin.A scientific method of skin classification based on the two factors of water holding capacity and skin surface lipid was developed. In addition to the three generally recognized skin types, an oily skin type characterized by dryness and roughness was identified. This paper presents a simple and reliable method for classifying skin types which has been approved from both dermatological and cosmetological aspects.
Tris(N,N,N′,N′,N′′,N′′-hexaethylguanidinium) dodecaiodidotribismuthate(III) (2016)

The asymmetric unit of title compound, (C 13 H 30 N 3 ) 3 [Bi 3 I 12 ], comprises one cation and two independent (1/6) fragments of the [Bi 3 I 12 ] 3− ions. The C—N bond lengths in the guanidinium ion range from 1.340 (4) to 1.345 (4) Å, indicating partial double-bond character pointing towards charge delocalization within the NCN planes. The Bi III ions are distorted octahedrally coordinated by six iodide ions, with Bi—I bond lengths ranging from 2.9206 (3) to 3.3507 (3) Å. Three [BiI 6 ] 3− octahedra are fused together through face-sharing, forming a trinuclear [Bi 3 I 12 ] 3− unit.
Direct Identification of Rituximab Main Isoforms and Subunit Analysis by Online Selective Comprehensive Two-Dimensional Liquid Chromatography–Mass Spectrometry (2015)

In this proof-of-concept study, rituximab, which is a reference therapeutic monoclonal antibody (mAb), was characterized through the implementation of online, selective comprehensive two-dimensional liquid chromatography (sLC×LC) coupled with mass spectrometry (MS), using a middle-up approach. In this setup, cation exchange chromatography (CEX) and reverse-phase liquid chromatography (RPLC) were used as the first and second separation dimensions, respectively. As illustrated in this work, the combination of these two chromatographic modes allows a direct assignment of the identities of CEX peaks, using data from the TOF/MS detector, because RPLC is directly compatible with MS detection, whereas CEX is not. In addition, the resolving power of CEX is often considered to be limited; therefore, this 2D approach provides an improvement in peak capacity and resolution when high-performance second-dimension separations are used, instead of simply using the second-dimension separation as a desalting step. This was particularly relevant when separating rituximab fragments of medium size (25 kDa), whereas most of the resolution was provided by CEX in the case of intact rituximab samples. The analysis of a commercial rituximab sample shows that online sLC×LC-TOF-MS can be used to rapidly characterize mAb samples, yielding the identification of numerous variants, based on the analysis of intact, partially digested, and digested/reduced mAb samples.
Syndecan recycling [corrected] is controlled by syntenin-PIP2 interaction and Arf6. (2005)

Syndecans are heparan sulfate proteoglycans that modulate the activity of several growth factors and cell adhesion molecules. PDZ domains in the adaptor protein syntenin interact with syndecans and with the phosphoinositide PIP(2), which is involved in the regulation of the actin cytoskeleton and membrane trafficking. Here, we show that the syntenin PDZ domain-PIP(2) interaction controls Arf6-mediated syndecan recycling through endosomal compartments. FGF receptor accompanies syndecan along the syntenin-mediated recycling pathway, in a heparan sulfate- and FGF-dependent manner. Syndecans that cannot recycle via this pathway become trapped intracellularly and inhibit cell spreading. This syntenin-mediated syndecan recycling pathway may regulate the surface availability of a number of cell adhesion and signaling molecules.
Inhibition of AMP-activated Protein Kinase α (AMPKα) by Doxorubicin Accentuates Genotoxic Stress and Cell Death in Mouse Embryonic Fibroblasts and Cardiomyocytes (2012)

Doxorubicin, an anthracycline antibiotic, is widely used in cancer treatment. Doxorubicin produces genotoxic stress and p53 activation in both carcinoma and non-carcinoma cells. Although its side effects in non-carcinoma cells, especially in heart tissue, are well known, the molecular targets of doxorubicin are poorly characterized. Here, we report that doxorubicin inhibits AMP-activated protein kinase (AMPK) resulting in SIRT1 dysfunction and p53 accumulation. Spontaneously immortalized mouse embryonic fibroblasts (MEFs) or H9C2 cardiomyocyte were exposed to doxorubicin at different doses and durations. Cell death and p53, SIRT1, and AMPK levels were examined by Western blot. In MEFs, doxorubicin inhibited AMPK activation, increased cell death, and induced robust p53 accumulation. Genetic deletion of AMPKα1 reduced NAD(+) levels and SIRT1 activity and significantly increased the levels of p53 and cell death. Pre-activation of AMPK by 5-aminoimidazole-4-carboxamide ribonucleoside or transfection with an adenovirus encoding a constitutively active AMPK (AMPK-CA) markedly reduced the effects of doxorubicin in MEFs from Ampkα1 knock-out mice. Conversely, pre-inhibition of Ampk further sensitized MEFs to doxorubicin-induced cell death. Genetic knockdown of p53 protected both wild-type and Ampkα1(-/-) MEFs from doxorubicin-induced cell death. p53 accumulation in Ampkα1(-/-) MEFs was reversed by SIRT1 activation by resveratrol. Taken together, these data suggest that AMPK inhibition by doxorubicin causes p53 accumulation and SIRT1 dysfunction in MEFs and further suggest that pharmacological activation of AMPK might alleviate the side effects of doxorubicin.
Semi-physical modeling of the vertical vehicle dynamics (1999)

Globalization and growing new markets force the car manufacturers to work faster and more efficient in developing new safety and comfort features for their vehicles. Hence, time-consuming expensive testing is more and more replaced by computer simulations. Normally, these simulations are based on complex physical models describing the dynamic behavior of the vehicle and its components. Sometimes, physical modeling of the nonlinear behavior of certain vehicle components can be very difficult. In these cases, neural networks may be used to model the systems' nonlinearities. The paper discusses the advantages of combining physical modeling with neural networks for a semi-physical process model. The vertical vehicle dynamics are used as example.