gebhart/patrepeval huggingface dataset:
Twice-daily re-irradiation of recurrent and second primary head and neck cancer with gemcitabine, paclitaxel and fluorouracil chemoradiotherapy (2004)

5510 Background: Sixty-nine patients with locally advanced head and neck cancer enrolled in a Phase I study of aggressive chemoradiotherapy with concurrent gemcitabine (dose-escalated from 50–300 mg/m2), paclitaxel (100 mg/m2) and 5-fluorouracil (600 mg/m2/d for 5 days) in conjunction with twice daily radiation (1.5 Gy) delivered on an alternating week schedule (TGFX). Here we report the clinical outcome and late toxicity of TGFX in a subset of patients previously irradiated to the head and neck. Methods: Twenty-nine previously irradiated patients presenting with recurrent or second primary head and neck cancer were treated with TGFX. Twelve patients underwent attempted surgical resection prior to chemoradiotherapy, of which 10 were left with no measurable disease. Patients with measurable disease were treated to a median dose of 72 Gy, while those with no measurable disease were treated to a median dose of 61 Gy. The cumulative radiation dose ranged from 74.4 to 156.4 Gy with a mean and median of 125.7 Gy and 131.0 Gy respectively. Results: The median follow-up was 19.1 months for all patients and 48.1 months for living patients. At 5 years, the overall survival (OS) is 37.6%, cause specific survival is 39.3%, and locoregional control (LRC) is 54.5%. In patients with measurable disease at the time of treatment, the 5-year OS and LRC are 26.3% and 45.1% respectively as compared to 5-year OS and LRC of 58.3% (p=0.09) and 70% (p=0.31) for those with no measurable disease. Measurable disease and radiation dose were highly significant for OS and LRC on mulitivariate analysis. Of 14 patients assessable for late toxicity, three developed grade (G) 4–5 toxicity, eight G 2–3 and three G 0–1. Six patients developed soft tissue complications: G5 in 1, G4 in 2 and G3 in 3. Six patients developed swallowing complications, of which 3 were gastrostomy tube dependent. Conclusions: Aggressive reirradiation with chemotherapy in locally advanced head and neck cancer provides a chance for long-term cure at the expense of acute and late toxicity. Attempted surgical resection prior to chemoradiation improves disease control and survival. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Eli Lilly
A Novel Class of Sodium/Calcium Exchanger Inhibitors: Design, Synthesis and Structure—Activity Relationships of 4‐Phenyl‐3‐(piperidin‐4‐yl)‐3,4‐dihydro‐2(1H)‐quinazolinone Derivatives. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Increased Fc-Receptor-Mediated Clearance via Reticuloendothelial System in Patients with Nephrotic Syndrome (1991)

Reticuloendothelial phagocytic cell function, which is an important participant in host defense, was investigated by studying the Fc-receptor-mediated clearance of IgG-anti-RhD-sensitized radiolabelled autologous erythrocytes in patients with nephrotic syndrome known to have an increased risk of infectious complications due to hypogammaglobulinemia. Patients with serum IgG concentrations less than 500 mg/dl had a significantly accelerated Fc-receptor-mediated clearance (t1/2 = 52 +/- 3.6 min) compared to patients with IgG levels greater than 500 mg/dl (t1/2 = 93 +/- 17 min) or healthy controls (t1/2 = 100 +/- 7.5 min). Serum IgG concentrations correlated significantly with Fc-receptor-mediated clearance (t1/2: r = 0.70; p = 0.035) in patients with nephrotic syndrome. These results indicate that Fc-receptor-mediated clearance by the reticuloendothelial system is enhanced in patients with nephrotic syndrome with low serum IgG concentrations and may, at least in part, compensate for reduced opsonic antibody concentration.
New Dihydro Derivatives of Tomatidine and Solasodine1 (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew Dihydro Derivatives of Tomatidine and Solasodine1Yoshio Sato and H. George Latham Jr.Cite this: J. Am. Chem. Soc. 1956, 78, 13, 3150–3153Publication Date (Print):July 1, 1956Publication History Published online1 May 2002Published inissue 1 July 1956https://pubs.acs.org/doi/10.1021/ja01594a048https://doi.org/10.1021/ja01594a048research-articleACS PublicationsRequest reuse permissionsArticle Views81Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Microencapsulated Dopamine (DA)‐Induced Restitution of Function in 6‐OHDA‐Denervated Rat Striatum in vivo: Comparison Between Two Microsphere Excipients (1991)

Biodegradable controlled-release microsphere systems made with the biocompatible biodegradable polyester excipient poly [DL lactide-co-glycolide] constitute an exciting new technology for drug delivery to the central nervous system (CNS). The present study describes functional observations indicating that implantation of dopamine (DA) microspheres encapsulated within two different polymer excipients into denervated-striatal tissue assures a prolonged release of the transmitter in vivo. Moreover, in this regard, the results show that there were clear cut temporal differences in the effect of the two DA microsphere formulations compared in this study, probably reflecting variations in the actual composition (i.e., lactide to glycolide ratio) of the two copolymer excipients examined. This technology has considerable potential for basic research with possible clinical application.
Geometric Phase Associated with Mode Transformations of Optical Beams Bearing Orbital Angular Momentum (2003)

We present direct measurements of a new geometric phase acquired by optical beams carrying orbital angular momentum. This phase arises when the transverse mode of a beam is transformed following a closed path in the space of modes. The measurements were done via the interference of two copropagating optical beams that pass through the same interferometer parts but acquire different geometric phases. The method is insensitive to dynamical phases. The magnitude and sign of the measured phases are in excellent agreement with theoretical predictions.
Nitric Oxide and Cyclic GMP Signaling Pathway as a Focus for Drug Development (2011)

Recent progress in understanding of the nitric oxide and cGMP signaling pathway provided evidence for mechanism of action of known drugs and identified novel targets for drug development. These discoveries resulted in numerous efforts in drug and formulation discovery. Some of the most promising approaches were applied for efficient therapies of various diseases.
METASTATIC CAUDATE LOBE CANCER RESECTED WITH PARTIAL RESECTION OF INFERIOR VENA CAVA USING BIO-PUMP® (1991)

Recent widespread application of hepatectomy for liver cancer is remarkable by applying techniques developed in vascular surgery. We experienced a case of solitary metastatic caudate lobe cancer which could be resected with combined partial resction of inferior vena cava using Bio-pump®. Primary hepatocellular carcinomas arising in the caudate lobe are rare, especially metastatic ones are, of course, so rare that only 2 cases have been reported.A 74-year-old male under postoperative follow-up for sigmoid colon cancer was indicated an elevated CEA level and diagnosed as solitary metastatic caudate lobe cancer. As the inferior vena cava was involved, venovenous bypass operation using Bio-pump® was performed between right axillar vein and right major sapherous vein, followed by safe and sure caudate lobectomy combined with partial resection of inferior vena cava. The tumor was histologically confirmed as liver metastasis of sigmoid colon cancer.
ChemInform Abstract: A Convenient One‐Pot Conversion of N‐Boc‐β‐aminoalcohols into N‐ Boc‐aziridines. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Functional correction of dystrophin actin binding domain mutations by genome editing (2017)

Dystrophin maintains the integrity of striated muscles by linking the actin cytoskeleton with the cell membrane. Duchenne muscular dystrophy (DMD) is caused by mutations in the dystrophin gene (DMD) that result in progressive, debilitating muscle weakness, cardiomyopathy, and a shortened lifespan. Mutations of dystrophin that disrupt the amino-terminal actin-binding domain 1 (ABD-1), encoded by exons 2-8, represent the second-most common cause of DMD. In the present study, we compared three different strategies for CRISPR/Cas9 genome editing to correct mutations in the ABD-1 region of the DMD gene by deleting exons 3-9, 6-9, or 7-11 in human induced pluripotent stem cells (iPSCs) and by assessing the function of iPSC-derived cardiomyocytes. All three exon deletion strategies enabled the expression of truncated dystrophin protein and restoration of cardiomyocyte contractility and calcium transients to varying degrees. We show that deletion of exons 3-9 by genomic editing provides an especially effective means of correcting disease-causing ABD-1 mutations. These findings represent an important step toward eventual correction of common DMD mutations and provide a means of rapidly assessing the expression and function of internally truncated forms of dystrophin-lacking portions of ABD-1.
Real-Time Multicast and Memory Replication Channels with Delay Bounded Error Detection and Retry Capabilities (2011)

In order to accommodate different requirements of reliable multicast applications, the real-time reliable multicasting support framework must possess generic yet rich features for detecting and reporting message losses with tight latency bounds. One highly promising concrete formulation of a multicast framework is the Real-time Multicast & Memory Replication Channel (RMMC) scheme. In this paper, we present the Delay-Bounded Reliable RMMC (DBR-RMMC) scheme, which extends the RMMC scheme in order to yield tight bounds on the latencies in detecting and reporting message losses over RMMCs and to enable application layer to initiate timely recovery actions. The DBR-RMMC scheme offers an API that allows application developers to freely explore the various design dimensions of reliable multicast applications while assuring timeliness. We also discuss a middleware subsystem devised to support DBRRMMC, followed by a summary of several analytical results on the bounds for latencies in reacting to the occurrence of a message loss. Experiments involving a real-time video streaming application have been conducted and encouraging results are presented.
Highly-damage-resistant quasi-phase-matched wavelength converter using ZnO-doped LiNbO/sub 3/ (2003)

An all-optical wavelength converter is one of the key devices for realizing future high-speed and flexible wavelength-division multiplexed (WDM) networks. 1.55 /spl mu/m-band quasi-phase-matched (QPM) wavelength converters based on difference frequency generation (DFG) in periodically poled LiNbO/sub 3/ (LN) are promising for this application because of their novel features, such as multi-channel conversion, high-efficiency, low noise, and transparency to bit-rate and data format. However, a QPM-LN wavelength converter using congruent LN exhibits photorefractive damage when it is injected with a high-power pump light. One approach to reducing photorefractive damage is to use MgO- or ZnO-doped LN. In this paper, we report a highly-damage-resistant QPM wavelength converter that uses a ZnO-doped LN substrate. The high damage resistance allows high-intensity pumping, which results in high conversion efficiency.
Selective Production of Horizontal Openhole Completions Using ECP and Sliding Sleeve Technology (1999)

Abstract Openhole horizontal completions using external casing packers (ECPs) for zonal isolation are a growing trend in the oil industry. This style of completion is installed with slotted pipe or screen across production intervals that are isolated by ECPs. This method, integrated with standard liner hanger equipment set in one trip, allows for production at a lower completion cost, but it also minimizes the options for water shutoff or shutoff of a naturally depleting interval. As companies continue to implement openhole horizontal completions, they look for alternatives that will provide precise zonal isolation while reducing installation time. This paper addresses an alternative isolation method wherein nonelastomeric sliding sleeves replace the slotted pipe between the ECPs. This method enables the operator to increase production while shutting off undesired intervals, thus fully optimizing the production program. With the use of coiled tubing and hydraulically actuated tools, sliding sleeve manipulation can be accomplished in long-reaching horizontal wellbores. The manipulation of these sleeves can increase production while shutting off undesired intervals. These sliding sleeve isolation systems have been installed and successfully operated in numerous horizontal wellbores in the Rocky Mountain Region and worldwide. Sliding sleeve systems have been successfully manipulated using coiled tubing methods, even when placed at 90° angles, true horizontal. The capability of shifting sliding sleeves in the horizontal position by utilizing coiled tubing hydraulically actuated shifting tools will be demonstrated in the paper. This allows for the selective opening or closing of multiple sleeves in a single trip. Utilizing sliding sleeves to control well inflow can improve well economics by shutting off unwanted water or gas production.
In-situ monitoring and control for the growth of highly reproducible VCSEL structures (2002)

Summary form only given. This paper reviews the pyrometric interferometry technique, and compares it with other in-situ and ex-situ methods for epitaxial growth monitoring and control. Highly reproducible vertical cavity surface emitting lasers (VCSEL) structures are used as an example to demonstrate the effectiveness of the in-situ monitoring and control technique. The authors use the pyrometric interferometry technique for in-situ monitoring and feedback control of layer thickness to obtain highly reproducible distributed Bragg reflectors (DBR) for 980- and 780-nm vertical cavity surface emitting lasers (VCSEL).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Evaluation of 22 genetic variants with Crohn's Disease risk in the Ashkenazi Jewish population: a case-control study (2011)

CD-associated genetic risks were similar to those reported in NJ population and are unlikely to explain the excess prevalence of the disease in AJ individuals. These results support the existence of novel, yet unidentified, genetic variants unique to this population. Understanding of ethnic and racial differences in disease susceptibility may help unravel the pathogenesis of CD leading to new personalized diagnostic and therapeutic approaches.
Autonomous evasive maneuvers triggered by infrastructure-based detection of pedestrian intentions (2013)

We present an active pedestrian protection system that performs an autonomous lane-keeping evasive maneuver in urban traffic scenarios when collision avoidance by braking is no longer possible. The system focuses on pedestrians standing at the curb and intending to cross the street despite an approaching car. It is demonstrated that the evasive maneuver of the car can be initiated before the pedestrian's foot hits the lane, by means of video-based motion contour histograms of oriented gradients and stationary detection. Using clothoid-based real-time trajectory planning and a lateral control of the car, combining feedforward and feedback control, the difference between the driven and the calculated trajectories is kept below 10 cm at maximum lateral accelerations of 4 ms <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> and -5 ms <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> . We present the technical realization of the system and its precision with respect to intention recognition and driven trajectories. A case study showed that the system reacted faster than human drivers in five out of 11 cases, with an average time gain of 214 ms, even though the drivers were able to pay the utmost attention to the behavior of the crossing pedestrian.
Preparation of Cyclonucleosides (2009)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTPreparation of CyclonucleosidesAdam Mieczkowski†, Vincent Roy, and Luigi A. Agrofoglio*View Author Information Institut de Chimie Organique et Analytique, UMR CNRS 6005, Université d'Orléans, BP 6759, 45067 Orléans Cedex 2, France* To whom correspondence should be addressed. Phone: (+33)-2-3849-4582. Fax: (+33)-2-3841-7281. E-mail: [email protected]†Present address: Department of Chemistry, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.Cite this: Chem. Rev. 2010, 110, 4, 1828–1856Publication Date (Web):December 23, 2009Publication History Received3 October 2009Published online23 December 2009Published inissue 14 April 2010https://pubs.acs.org/doi/10.1021/cr900329yhttps://doi.org/10.1021/cr900329yreview-articleACS PublicationsCopyright © 2009 American Chemical SocietyRequest reuse permissionsArticle Views4874Altmetric-Citations68LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Aromatic compounds,Cyclization,Nucleic acids,Pyrimidine,Reaction products Get e-Alerts
Broadband Millimeter-Wave Propagation Measurements and Models Using Adaptive-Beam Antennas for Outdoor Urban Cellular Communications (2013)

The spectrum crunch currently experienced by mobile cellular carriers makes the underutilized millimeter-wave frequency spectrum a sensible choice for next-generation cellular communications, particularly when considering the recent advances in low cost sub-terahertz/millimeter-wave complementary metal-oxide semiconductor circuitry. To date, however, little is known on how to design or deploy practical millimeter-wave cellular systems. In this paper, measurements for outdoor cellular channels at 38 GHz were made in an urban environment with a broadband (800-MHz RF passband bandwidth) sliding correlator channel sounder. Extensive angle of arrival, path loss, and multipath time delay spread measurements were conducted for steerable beam antennas of differing gains and beamwidths for a wide variety of transmitter and receiver locations. Coverage outages and the likelihood of outage with steerable antennas were also measured to determine how random receiver locations with differing antenna gains and link budgets could perform in future cellular systems. This paper provides measurements and models that may be used to design future fifth-generation millimeter-wave cellular networks and gives insight into antenna beam steering algorithms for these systems.
A Facile One-pot Synthesis of Pyrido[2,3-d]pyrimidines and Pyrido[2,3-d:6,5-d′]dipyrimidines (1999)

The reactions of enaminones (6-aminouracils) 1a–c and 4 with cyano olefins 2a–b and 5a–f led to the formation of pyrido[2,3-d]pyrimidines 3a–f and 6a–f in good yield, while the treatment of 4-amino-2-thiouracil 4 with aromatic aldehydes afforded pyridodipyrimidines 7a–c.
Non-Invasive Monitoring of Glucose Level Changes Utilizing a mm-Wave Radar System (2018)

This article discusses recent developments in the authors' experiments using Google's Soli alpha kit to develop a non-invasive blood glucose detection system. The Soli system (co-developed by Google and Infineon) is a 60 GHz mm-wave radar that promises a small, mobile, and wearable platform intended for gesture recognition. They have retrofitted the setup for the system and their experiments outline a proof-of-concept prototype to detect changes of the dielectric properties of solutions with different levels of glucose and distinguish between different concentrations. Preliminary results indicated that mm-waves are suitable for glucose detection among biological mediums at concentrations similar to blood glucose concentrations of diabetic patients. The authors discuss improving the repeatability and scalability of the system, other systems of glucose detection, and potential user constraints of implementation.
Rethinking Knowledge Graph Propagation for Zero-Shot Learning (2019)

Graph convolutional neural networks have recently shown great potential for the task of zero-shot learning. These models are highly sample efficient as related concepts in the graph structure share statistical strength allowing generalization to new classes when faced with a lack of data. However, multi-layer architectures, which are required to propagate knowledge to distant nodes in the graph, dilute the knowledge by performing extensive Laplacian smoothing at each layer and thereby consequently decrease performance. In order to still enjoy the benefit brought by the graph structure while preventing dilution of knowledge from distant nodes, we propose a Dense Graph Propagation (DGP) module with carefully designed direct links among distant nodes. DGP allows us to exploit the hierarchical graph structure of the knowledge graph through additional connections. These connections are added based on a node's relationship to its ancestors and descendants. A weighting scheme is further used to weigh their contribution depending on the distance to the node to improve information propagation in the graph. Combined with finetuning of the representations in a two-stage training approach our method outperforms state-of-the-art zero-shot learning approaches.