gebhart/patrepeval huggingface dataset:
A Study of an Oxidative-amination Method for the Synthesis of Aminoquinones1 (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Study of an Oxidative-amination Method for the Synthesis of Aminoquinones1Alan H. Crosby and Robert E. LutzCite this: J. Am. Chem. Soc. 1956, 78, 6, 1233–1235Publication Date (Print):March 1, 1956Publication History Published online1 May 2002Published inissue 1 March 1956https://pubs.acs.org/doi/10.1021/ja01587a042https://doi.org/10.1021/ja01587a042research-articleACS PublicationsRequest reuse permissionsArticle Views486Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Self-Organizing Pedestrian Movement (2001)

Although pedestrians have individual preferences, aims, and destinations, the dynamics of pedestrian crowds is surprisingly predictable. Pedestrians can move freely only at small pedestrian densities. Otherwise their motion is affected by repulsive interactions with other pedestrians, giving rise to self-organization phenomena. Examples of the resulting patterns of motion are separate lanes of uniform walking direction in crowds of oppositely moving pedestrians or oscillations of the passing direction at bottlenecks. If pedestrians leave footprints on deformable ground (for example, in green spaces such as public parks) this additionally causes attractive interactions which are mediated by modifications of their environment. In such cases, systems of pedestrian trails will evolve over time. The corresponding computer simulations are a valuable tool for developing optimized pedestrian facilities and way systems.
Produktionsreihenfolgeplanung in Ringwalzwerken mit wissensbasierten und evolutionären Methoden (1998)

Article Produktionsreihenfolgeplanung in Ringwalzwerken mit wissensbasierten und evolutionären Methoden was published on January 1, 1998 in the journal at - Automatisierungstechnik (volume 46, issue 1).
High-performance AEM unitized regenerative fuel cell using Pt-pyrochlore as bifunctional oxygen electrocatalyst (2021)

The performance of fixed-gas unitized regenerative fuel cells (FG-URFCs) are limited by the bifunctional activity of the oxygen electrocatalyst. It is essential to have a good bifunctional oxygen electrocatalyst which can exhibit high activity for oxygen evolution reaction (OER) and oxygen reduction reaction (ORR). In this regard, Pt-Pb<sub>2</sub>Ru<sub>2</sub>O<sub>7-x</sub> is synthesized by depositing Pt on Pb<sub>2</sub>Ru<sub>2</sub>O<sub>7-x</sub> wherein Pt individually exhibits high ORR while Pb<sub>2</sub>Ru<sub>2</sub>O<sub>7-x</sub> shows high OER and moderate ORR activity. Pt-Pb<sub>2</sub>Ru<sub>2</sub>O<sub>7-x</sub> exhibits higher OER (η<sub>@10mAcm-2</sub> = 0.25 ± 0.01 V) and ORR (η<sub>@-3mAcm-2</sub> = -0.31 ± 0.02 V) activity in comparison to benchmark OER (IrO<sub>2</sub>, η<sub>@10mAcm-2</sub> = 0.35 ± 0.02 V) and ORR (Pt/C, η<sub>@-3mAcm-2</sub> = -0.33 ± 0.02 V) electrocatalysts, respectively. Pt-Pb<sub>2</sub>Ru<sub>2</sub>O<sub>7-x</sub> shows a lower bifunctionality index (η<sub>@10mAcm-2, OER</sub><sup>-</sup> η<sub>@-3mAcm-2, ORR</sub>) of 0.56 V with more symmetric OER-ORR activity profile than both Pt (>1.0 V) and Pb<sub>2</sub>Ru<sub>2</sub>O<sub>7-x</sub> (0.69 V) making it more useful for the AEM (anion exchange membrane) URFC or metal-air battery applications. FG-URFC tested with Pt-Pb<sub>2</sub>Ru<sub>2</sub>O<sub>7-x</sub> and Pt/C as bifunctional oxygen electrocatalyst and bifunctional hydrogen electrocatalyst, respectively, yields a mass-specific current density of 715 ± 11 A/g<sub>cat</sub><sup>-1</sup> at 1.8 V and 56 ± 2 A/g<sub>cat</sub><sup>-1</sup> at 0.9 V under electrolyzer mode and fuel-cell mode, respectively. The FG-URFC shows a round-trip efficiency of 75% at 0.1 A/cm<sup>-2</sup>, underlying improvement in AEM FG-URFC electrocatalyst design.
Splanchnic Increase in Induced by Rat Nerve Activation Inhibits the Duodenal HC03- Secretion Luminal Acidification in the (1989)

Acid exposure of the duodenal mucosa increased duodenal HCO,- secretion by -60%. When the acid exposure was performed simultaneously with an arterial bleeding of 0.6 ml/100 g body wt (10% of the total blood volume), the increase in duodenal HCO,- secretion was totally abolished. When the acid exposure and bleeding procedures were performed at the same time in rats with bilaterally cut splanchnic nerves, alkaline secretion increased by SO%, as it did in the unbled rats. Direct electrical stimulation of the splanchnic nerves (10 Hz, supramaximal intensity) inhibited the stimulatory effect of duodenal acid exposure on alkaline secretion. Taken together, the data suggest that the sympathetic nervous system, because of splanchnic nerve activation, inhibits the acid-induced increase in duodenal HCO,- secretion.
Salicylate inhibits fimbriae mediated HEp-2 cell adherence of and haemagglutination by enteroaggregative Escherichia coli (1998)

Enteroaggregative Escherichia coli (EAggEC) are associated with both acute and persistent diarrhoea in children. Bowel colonisation due to fimbrial adherence factors appears to play a major role in the disease process. In this study, we investigated the effect of sodium salicylate and 5-aminosalicylic acid on adherence of a type strain and 40 clinical isolates of EAggEC to HEp-2 cells and erythrocytes from different species. Growth in the presence of 10 mM salicylate resulted in markedly decreased adherence to tissue culture cells with 33/40 (82.5%) isolates, and was also associated with inhibition of haemagglutination in 20/33 (60.6%) isolates. Complete or partial inhibition of adherence was also seen in two of five isolates showing localised adherence and three of five isolates with diffuse adherence. Decrease in adherence was associated with decreased or absent expression of fimbriae in 28/40 (70%) of the EAggEC isolates, although production of outer membrane proteins was not affected. Salicylates appear to inhibit adherence mediated by fimbrial adhesins.
I-387, a Novel Antimitotic Indole, Displays a Potent In vitro and In vivo Antitumor Activity with Less Neurotoxicity (2010)

(3-(1H-indol-2-yl)phenyl)(3,4,5-trimethoxyphenyl)methanone (I-387) is a novel synthetic compound that inhibits tubulin action and exhibits potent antitumor activity in various preclinical models. I-387 inhibited the in vitro growth of several human cancer cell lines with IC₅₀ values in the range of 15 to 39 nmol/L. Nanomolar concentrations of the compound induced apoptosis and caused phosphorylation of the antiapoptotic protein Bcl-2. I-387 induced a strong and concentration-dependent G₂-M arrest in PC-3 cells by constitutive activation of Cdc2/cyclin B1 complex and destabilized polymerization of purified tubulin in vitro by binding to the colchicine-binding site. In vivo, I-387 treatment effectively inhibited tumor growth in mice bearing PC-3 tumor xenografts. In vitro studies of nerve growth factor-dependent neurite outgrowth in PC12 pheochromocytoma cells and in vivo studies of mouse behavior showed that I-387 was less neurotoxic than vinblastine and vincristine, tubulin destabilizers with known neurotoxicity. Interestingly, multidrug-resistant cell lines that overexpressed P-glycoprotein (P-gp), multidrug resistance-associated proteins, and breast cancer resistance protein were rendered resistant to docetaxel, vinblastine, SN-38, and doxorubicin, but not to I-387. I-387 dosed at 10 mg/kg was equally effective with 76% tumor growth inhibition in xenograft models using MES-SA uterine sarcoma cells and MES-SA/DX5 cells overexpressing P-gp. In contrast, docetaxel and vinblastine were not effective in MES-SA/DX5 xenograft models. The potent in vitro and in vivo antitumor activity of I-387 suggests that it may represent a new antimitotic agent for management of various malignancies, particularly for patients with drug-resistant cancer.
Application of Conformation Design in Acyclic Stereoselection:  Total Synthesis of Borrelidin as the Crystalline Benzene Solvate (2003)

The total synthesis of (-)-borrelidin (treponemycin), a structurally distinct 18-membered macrolide antibiotic, has been achieved. It was isolated as the crystalline benzene solvate, and its structure was confirmed by a single-crystal X-ray analysis. The deoxypropionate subunit consisting of four alternating C-methyl groups with a C(4)-C(10) syn/syn/anti orientation was elaborated by a new method of iterative cuprate additions to acyclic alpha,beta-unsaturated esters relying on two consecutive 1,3-inductions and starting with d-glyceraldehyde as the chiral progenitor. The unique Z/E cyanodiene unit was obtained as a single isomer by application of the Still-Gennari olefination protocol. The gamma-hydroxycyclopentane carboxylic acid subunit was prepared from L-malic acid utilizing a sequential introduction of C-vinyl and C-allyl groups, capitalizing on 1,2-induction in an acyclic alpha,beta-unsaturated ester and carbocyclization by a Grubbs ring closure metathesis reaction. The prevalence of 1,3-syn-disposed deoxypropionate triads in the cuprate additions is rationalized on the basis of minimized syn-pentane interactions in the transition states. A virtual diamond lattice was used as a visual tool to portray the low-energy conformations of the acyclic substrates, and corroborated by (1)H NMR homodecoupling studies.
Organometallic vapor phase epitaxial growth of (Al/sub x/Ga/sub 1-x/)/sub 0.5/In/sub 0.5/P and its heterostructures (1988)

Low pressure organometallic vapor-phase epitaxial growth of Ga/sub 0.5/In/sub 0.5/P and (Al/sub x/Ga/sub 1-x/)/sub 0.5/In/sub 0.5/P is examined. Epitaxial layers of bulk materials are characterized using photoluminescence, electroreflectance, Raman scattering spectroscopy, and surface morphology studies to determine lattice match and optimum growth conditions. Lattice matching at the growth temperature produces featureless growth surfaces, while lattice matching at room temperatures results in minimum photoluminescence linewidth but cracked surfaces due to tensile strain during growth. Raman scattering spectra of the quaternary reveal a three mode structure, with spectral peaks due to GaP-like, InP-like, and AIP-like LO phonons. Heterostructures are investigated including quantum shifts from a series of superlattices. These materials are incorporated in double-heterostructure lasers and single-quantum-well laser with graded-index separate confinement heterostructure.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Dual‐Stage Light Amplified Photodynamic Therapy against Hypoxic Tumor Based on an O2 Self‐Sufficient Nanoplatform (2017)

Tumor hypoxia severely limits the efficacy of traditional photodynamic therapy (PDT). Here, a liposome-based nanoparticle (designated as LipoMB/CaO<sub>2</sub> ) with O<sub>2</sub> self-sufficient property for dual-stage light-driven PDT is demonstrated to address this problem. Through a short time irradiation, <sup>1</sup> O<sub>2</sub> activated by the photosensitizer methylene blue (MB) can induce lipid peroxidation to break the liposome, and enlarge the contact area of CaO<sub>2</sub> with H<sub>2</sub> O, resulting in accelerated O<sub>2</sub> production. Accelerated O<sub>2</sub> level further regulates hypoxic tumor microenvironment and in turn improves <sup>1</sup> O<sub>2</sub> generation by MB under another long time irradiation. In vitro and in vivo experiments also demonstrate the superior competence of LipoMB/CaO<sub>2</sub> to alleviate tumor hypoxia, suppress tumor growth and antitumor metastasis with low side-effect. The O<sub>2</sub> self-sufficient LipoMB/CaO<sub>2</sub> nanoplatform with dual-stage light manipulation is a successful attempt for PDT against hypoxic tumor.
Comparing Electrochemical and Biological Water Splitting (2007)

On the basis of density functional theory calculations, we compare the free energies of key intermediates in the water splitting reaction over transition metal oxide surfaces to those of the Mn cluster in photo system II. In spite of the very different environments in the enzyme system and on the inorganic catalyst surface of an acidic electrolysis cell, the thermochemical features of the catalysts can be directly compared. We suggest a simple test for a thermochemically optimal catalyst. We show that, although both the RuO2 surface and the Mn cluster in photo system II are quite close to optimal, the biological catalyst appears to be best.
The coordination of bare iron(I) ion (Fe+) to aliphatic isonitriles differs from that of Fe+ and nitriles (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe coordination of bare iron(I) ion (Fe+) to aliphatic isonitriles differs from that of Fe+ and nitrilesKarsten. Eller, Carlito B. Lebrilla, Thomas. Drewello, and Helmut. SchwarzCite this: J. Am. Chem. Soc. 1988, 110, 10, 3068–3071Publication Date (Print):May 1, 1988Publication History Published online1 May 2002Published inissue 1 May 1988https://pubs.acs.org/doi/10.1021/ja00218a012https://doi.org/10.1021/ja00218a012research-articleACS PublicationsRequest reuse permissionsArticle Views101Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The effect of sunlight on human epidermis. A quantitative electron microscopic study of dendritic cells. (1970)

Qualitative as well as quantitative studies, including direct counting of cells and linear scanning of electron micrographs, to determine volume ratios for epidermal dendritic cells revealed an increase in melanocyte number and an essential absence of Langerhans' cells following two weeks of daily ultraviolet irradiation. These findings suggest some form of relationship between the melanocyte and the Langerhans' cell.
1-Methyl 2,3-dibutyl hemimellitate, a novel component of Viburnum prunifolium (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT1-Methyl 2,3-dibutyl hemimellitate, a novel component of Viburnum prunifoliumCharles H. Jarboe, Karimullah A. Zirvi, Charlotte M. Schmidt, Fred W. McLafferty, and William F. HaddonCite this: J. Org. Chem. 1969, 34, 12, 4202–4203Publication Date (Print):December 1, 1969Publication History Published online1 May 2002Published inissue 1 December 1969https://pubs.acs.org/doi/10.1021/jo01264a111https://doi.org/10.1021/jo01264a111research-articleACS PublicationsRequest reuse permissionsArticle Views90Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Three-Dimensional Quantitative Structure−Activity Relationships from Tuned Molecular Quantum Similarity Measures:  Prediction of the Corticosteroid-Binding Globulin Binding Affinity for a Steroid Family (1999)

Predictive models based on tuned molecular quantum similarity measures and their application to obtain quantitative structure-activity relationships (QSAR) are described. In the present paper, the corticosteroid-binding globulin binding affinity of a 31 steroid family is studied by means of a multilinear regression using molecular descriptors derived from mixed steric-electrostatic quantum similarity matrixes as parameters, obtaining satisfactory predictions. A systematic procedure to treat outliers by using triple-density quantum similarity measures is also presented. This method depicts an alternative to the grid-based QSAR techniques, providing a consistent approach that avoids problematic result dependency on the grid parameters.
Assessing the effect of interventions for axial spondyloarthritis according to the endorsed ASAS/OMERACT core outcome set: a meta-research study of trials included in Cochrane reviews (2020)

Abstract The Assessment of SpondyloArthritis international Society (ASAS) has defined core sets for (i) symptom-modifying anti-rheumatic drugs (SM-ARD), (ii) clinical record keeping, and (iii) disease-controlling anti-rheumatic therapy (DC-ART). These include the following domains for all three core sets: “physical function,” “pain,” “spinal mobility,” “spinal stiffness,” and “patient’s global assessment” (PGA). The core set for clinical record keeping further includes the domains “peripheral joints/entheses” and “acute phase reactants,” and the core set for DC-ART further includes the domains “fatigue” and “spine radiographs/hip radiographs.” The Outcome Measures in Rheumatology (OMERACT) endorsed the core sets in 1998. Using empirical evidence from axSpA trials, we investigated the efficacy (i.e., net benefit) according to the ASAS/OMERACT core outcome set for axSpA across all interventions tested in trials included in subsequent Cochrane reviews. For all continuous scales, we combined data using the standardized mean difference (SMD) to meta-analyze outcomes involving the same domains. Also, through meta-regression analysis, we examined the effect of the separate SMD measures (independent variables) on the primary endpoint (log [ OR ], dependent variable) across all trials. Based on 11 eligible Cochrane reviews, from these, 85 articles were screened; we included 43 trials with 63 randomized comparisons. Mean (SD) number of ASAS/OMERACT core outcome domains measured for SM-ARD/physical therapy trials was 4.2 (1.7). Six trials assessed all proposed domains. Mean (SD) for number of core outcome domains for DC-ART trials was 5.8 (1.7). No trials assessed all nine domains. Eight trials (16%) were judged to have inadequate (i.e., high risk of) selective outcome reporting bias. The most responsible core domains for achieving success in meeting the primary objective per trial were pain, OR (95% CI) 5.19 (2.28, 11.77), and PGA, OR (95% CI) 1.87 (1.14, 3.07). In conclusion, selective outcome reporting (and “missing data”) should be reduced by encouraging the use of the endorsed ASAS/OMERACT outcome domains in clinical trials. Overall outcome reporting was good for SM-ARD/physical therapy trials and poor for DC-ART trials. Our findings suggest that both PGA and pain provide a valuable holistic construct for the assessment of improvement beyond more objective measures of spinal inflammation.
ELECTROCHEMICAL STUDIES OF TETRACROWN-ETHER SUBSTITUTED PHTHALOCYANINES IN SOLUTION (1994)

Abstract Cyclic voltammetry of soluble metal-free and copper phthalocyanines with crown ethers attached to the periphery through oxymethyl bridges show two one-electron reduction processes on sweeping to negative potentials. The addition of sodium or potassium ions to the solution results in a decrease in diffusion coefficients, which is a consequence of intermolecular complex formation in the presence of these two cations.
Performance of an ℓ1 Regularized Subspace-Based MIMO Channel Estimation With Random Sequences (2015)

The conventional ℓ2 multiburst (MB) channel estimation can achieve the Cramér-Rao bound asymptotically by using the subspace projection. However, the ℓ2 MB technique suffers from the noise enhancement problem if the training sequences (TSs) are not ideally uncorrelated. We clarify that the problem is caused by an inaccurate noise whitening process. The ℓ1 regularized MB channel estimation can, however, improve the problem by a channel impulse response length constraint. Asymptotic performance analysis shows that the ℓ1 MB can improve channel estimation performance significantly over the ℓ2 MB technique in a massive multiple-input multiple-output system when the TSs are not long enough and not ideally uncorrelated.
Characteristic of the reflective type raman amplification in a dispersion compensating fiber (2004)

We demonstrate the characteristics of the reflective type distributed Raman amplifier in the dispersion compensating fiber which is composed of a circulator and a Faraday rotator mirror. With the same dispersion compensation, the gain of the reflective type is higher than that of the conventional single-pass type. Moreover, the forward pumping is better than the backward pumping in the reflective type dispersion compensating Raman amplifier. We also show that, by using the reflective type configuration, the polarization mode dispersion of dispersion compensating fiber can be almost compensated.
Medication Adherence with Interferon beta-1a Treatment Using an Electronic Injection Device: Data from a Prospective Scandinavian Non-Interventional Study (The Scansmart Study) (P01.202) (2013)

OBJECTIVE: The main aim of this study was to evaluate patient adherence to treatment with Rebif® using Rebismart® in RRMS patients. Injection site reactions (ISR) and patient satisfaction were analyzed using the multiple sclerosis treatment concern's questionnaire (MSTCQ).