gebhart/patrepeval huggingface dataset:
Exploring Motor Imagery Eeg Patterns for Stroke Patients with Deep Neural Networks (2018)

Studies show that motor imagery based Brain-Computer Interface (BCI) systems can be utilized therapeutically in stroke rehabilitation. Efficient decoding of subjects' motor intentions is essential in BCI-based rehabilitation systems to manipulate a neural prosthesis or other devices for motor relearning. However, due to cortical reorganization, the desynchro-nization potential evoked by the motor imagery of patients with brain lesions is quite different from that evoked by the motor imagery of normal subjects. These differences can be attributed to active cortex regions, frequency bands and amplitude. In this paper, we use a deep learning method to explore the EEG patterns of key channels and the frequency band for stroke patients. The EEG data is bandpass filtered into multiple sub-bands split by a sliding window strategy. Under these sub-bands, diverse spatial-spectral features are extracted and fed into a deep neural network for classification, uncovering the spectral patterns (bandpass filters) and spatial patterns (spatial weights). Experimental results from five stroke patients show that our method has higher classification accuracy than several state-of-the-art approaches. By tracking gradual changes in EEG patterns during rehabilitation, we try to uncover the neurophysiological plasticity mechanism in the impaired cortexes of stroke patients.
The Ethics of Interstitial and Cesarean Scar Ectopic Pregnancies (2018)

Catholic bioethicists have extensively addressed extrauterine tubal pregnancies, which represent the great majority of ectopic pregnancies. However, additional management options have been developed for the other 7-10 percent of ectopic pregnancies. Using two cases of interstitial pregnancy and two cases of cesarean scar pregnancy (CSP) seen at a Catholic tertiary care center, this article discusses options including expectant management, systemic methotrexate, intragestational methotrexate, intragestational potassium chloride, uterine artery embolization, dilation and curettage (D&C), vasopressin use, cornuostomy, cornual wedge resection, CSP evacuation, CSP scar excision, CSP salvage, and hysterectomy. Cornual wedge resection, vasopressin use, and CSP scar excision are morally acceptable; less clearly licit are aspiration of gestational sac contents, cornuostomy, gestational excision for CSPs, and methotrexate. Certainly illicit are any techniques leading to direct abortion such as D&Cs on live embryos or fetuses, double-balloon catheter placement, and use of potassium chloride. <b>Summary:</b> An ectopic pregnancy is any pregnancy outside the uterus. These are dangerous because the pregnancy can burst out of its abnormal location and cause life-threatening internal bleeding. Most are in the part of the fallopian tube outside the uterus, but there are other types, including interstitial pregnancies (located in the part of the tube tunneling through the uterine wall) and cesarean scar pregnancies (buried in the uterine scar where the cut for a C-section was made). This article lists the ways that physicians prevent women from dying from interstitial and cesarean scar pregnancies and proposes which treatments are morally acceptable.
Defenestration of the sinusoidal endothelial cell in a rat model of cirrhosis (1993)

We characterized the structural and immunohistological changes of sinusoidal endothelial cells that occur during cirrhosis in rats made cirrhotic with thioacetamide. Thioacetamide (200 mg/kg body wt) was injected intraperitoneally three times a week into male Wistar rats. Two, 4, 6 and 12 wk later, rat livers were observed under transmission and scanning electron microscopy and regular microscopy and immunostained with laminin and von Willebrand factor (factor VIII-related antigen) antibodies. The diameters and numbers of sinusoidal endothelial fenestrations did not change significantly after 2 wk in the thioacetamide-treated rats; however, they decreased within 4 wk after thioacetamide treatment. A basement membranelike structure in Disse's space was noted 6 wk after thioacetamide treatment. Laminin was detected in Disse's space after 4 wk. In vitro, in cultured sinusoidal endothelial cells, the diameter of sinusoidal endothelial fenestrations was significantly lower at 6 wk in thioacetamide-treated rats. von Willebrand factor was detected in the cytoplasm as granular fluorescence after 6 wk of thioacetamide treatment. These results suggest that as fibrosis develops in cirrhosis, the structural and immunohistochemical characteristics of sinusoidal endothelial cells change.
Pressure sensing in vacuum hermetic micropackaging for MOEMS-MEMS (2010)

Packaging constitutes one of the most costly steps of MEMS/MOEMS manufacturing. Uncooled IR bolometers require a vacuum atmosphere below 10 mTorr to operate at their highest sensitivity. The bolometer response is also dependent on the package temperature. In order to minimize cost, real estate and power consumption, temperature stabilization is typically not provided to the package. Hence, long term high sensitivity operation of IR bolometric radiometers requires a calibration as function of in package pressure and temperature. A low-cost and accurate means of measuring the pressure in the package without being affected by the operating temperature is therefore needed. INO has developed a low-cost, low-temperature hybrid vacuum micropackaging technology <sup>1-3</sup>. An equivalent flow rate of 4&times;10<sup>-14</sup> Torr·L/sec for storage at 80&deg;C has been obtained without getter. Even with such low flow, the long term stabilization of residual pressure variations affects the sensitivity and calibration of the IR bolometers. INO has developed MEMS pressure sensors that allow for real-time measurement of package pressure above 1 mTorr, and can be integrated with the IR bolometers in a die-level packaging process or microfabricated simultaneously on the same die. In this paper, the typical performance and measurement uncertainty of these pressure sensors will be presented along with a reading method that provides a pressure measurement with a dependence on the package temperature as low as 0.7 %/&deg;C. Complex reading circuit or temperature control of the packages are not required, making the pressure sensor well adapted for low-cost high-volume production and integration with IR bolometer arrays.
Intelligent Visual Supercomputing on Hybrid Graphical Multiprocessor Environments, Computer Engineering (2013)

info:eu-repo/semantics/nonPublished
Supplementary figure S1-S7 from TAS-116, a Novel Hsp90 Inhibitor, Selectively Enhances Radiosensitivity of Human Cancer Cells to X-rays and Carbon Ion Radiation (2023)

&lt;p&gt;Supplementary figure S1. Structure of TAS-116., Supplementary figure S2. TAS-116 inhibits DSB repair in irradiated H1299 cells., Supplementary figure S3. TAS-116 induces G2/M arrest in H1299 cells., Supplementary figure S4. Cell cycle distribution considering dead cell by TAS-116., Supplementary figure S5. Combined treatment with TAS-116 and irradiation does not synergistically increase sub-G1 cell population in HeLa cells., Supplementary figure S6. Combined treatment with TAS-116 and irradiation does not synergistically increase the expression levels of cleaved PARP and caspase 3 in HeLa cells., Supplementary figure S7. Combined treatment with TAS-116 and carbon ions decreased tumor size in a HeLa xenograft mouse model.&lt;/p&gt;
Development of the IRIS Collimator for the Portable Radiation Detector and Its Performance Evaluation Using the MCNP Code (2015)

When a radiation detector is applied to the measurement of the radioactivity of high-level of radioactive materials or the rapid response to the nuclear accident, several collimators with the different inner radii should be prepared according to the level of dose rate. This makes the in-situ measurement impractical, because of the heavy weight of the collimator. In this study, an IRIS collimator was developed so as to have a function of controlling the inner radius, with the same method used in optical camera, to vary the attenuation ratio of radiation. The shutter was made to have the double tungsten layers with different phase angles to prevent the radiation from penetrating owing to the mechanical tolerance. The performance evaluation through the MCNP code was conducted by calculating the attenuation ratio according to the inner radius of the collimator. The attenuation ratio was marked on the outer scale ring of the collimator. It is expected that when a radiation detector with the IRIS collimator is used for the in-situ measurement, it can change the attenuation ratio of the incident photon to the detector without replacing the collimator.
PALAEONTOLOGICAL STUDIES STUDIESON THE FOSSILS OF THE CRO-MAGNON MAN IN THE UPPER PALEOLITHIC AGE IN EURASIA (2004)

This research paper aims at to fix the exact status of Cro-Magnon Man in the line of evolution and to determine whether modern European human can be direct descendents of Cro-Magnon Man ant that whether biological changes of significant importance had happened between Cro-Magnon Man and modern man in Europe, Particularly in cranial features.
Successful Treatment of Chronic Staphylococcus aureus-Related Dermatoses with the Topical Endolysin Staphefekt SA.100: A Report of 3 Cases (2017)

<i>Staphylococcus aureus</i> plays an important role in skin and soft tissue infections and contributes to the pathophysiology of complex skin disorders such as atopic dermatitis. Bacterial resistance against commonly used antibiotics has increased considerably in the last decades demanding alternative treatment approaches. We present 3 cases where patients with chronic and recurrent <i>S. aureus</i>-related dermatoses were successfully treated with Staphefekt SA.100. Staphefekt SA.100 is a recombinant phage endolysin for topical skin application that specifically targets both methicillin-sensitive and methicillin-resistant <i>S. aureus.</i> As a consequence of its specific mechanism of action, bacterial resistance is unlikely to develop. In our 3 cases, resistance induction was not observed. Our results indicate that targeted treatment with Staphefekt might be an attractive alternative for (long-term) classical antibiotic therapy, and confirmatory randomized controlled trials are warranted to evaluate its clinical efficacy and safety.
Evaluation of MPC-based Imitation Learning for Human-like Autonomous Driving (2022)

This work evaluates and analyzes the combination of imitation learning (IL) and differentiable model predictive control (MPC) for the application of human-like autonomous driving. We combine MPC with a hierarchical learning-based policy, and measure its performance in open-loop and closed-loop with metrics related to safety, comfort and similarity to human driving characteristics. We also demonstrate the value of augmenting open-loop behavioral cloning with closed-loop training for a more robust learning, approximating the policy gradient through time with the state space model used by the MPC. We perform experimental evaluations on a lane keeping control system, learned from demonstrations collected on a fixed-base driving simulator, and show that our imitative policies approach the human driving style preferences.
Impact of a more restrictive overlapping surgery policy: an analysis of pre- and postimplementation complication rates, resident involvement, and surgical wait times at a high-volume neurosurgical department (2017)

OBJECTIVE Recently, overlapping surgery has been a source of controversy both in the popular press and within the academic medical community. There have been no studies examining the possible effects of more stringent overlapping surgery restrictions. At the authors' institution, a new policy was implemented that restricts attending surgeons from starting a second case until all critical portions of the first case that could require the attending surgeon's involvement are completed. The authors examined the impact of this policy on complication rates, neurosurgical resident education, and wait times for neurosurgical procedures. METHODS The authors performed a retrospective chart review of nonemergency neurosurgical procedures performed over two periods-from June 1, 2014, to October 31, 2014 (pre-policy change) and from June 1, 2016, to October 31, 2016 (post-policy change)-by any of 4 senior neurosurgeons at a single institution who were authorized to schedule overlapping cases. Information on preoperative evaluation, patient demographics, premorbid conditions, surgical variables, and postoperative course were collected and analyzed. RESULTS Six hundred fifty-three patients met inclusion criteria for complications analysis. Of these, 378 (57.9%) underwent surgery before the policy change. On multivariable regression analysis, neither overlapping surgery (odds ratio [OR] 1.072, 95% confidence interval [CI] 0.710-1.620) nor the overlapping surgery policy change (OR 1.057, 95% CI 0.700-1.596) was associated with overall complication rates. Similarly, neither overlapping surgery (OR 1.472, 95% CI 0.883-2.454) nor the overlapping surgery policy change (OR 1.251, 95% CI 0.748-2.091) was associated with numbers of serious complications. After the policy change, the percentage of procedures in which the senior assistant was a postresidency fellow increased significantly, from 11.9% to 34.2% (p < 0.001). In a multiple linear regression analysis of surgery wait times, patients undergoing surgery after the policy change had significantly longer delays from the decision to operate until the actual neurosurgical procedure (p < 0.001). CONCLUSIONS At the authors' institution, further restriction of overlapping surgery was not associated with a reduction in overall or serious complications. Resident involvement in neurosurgical procedures decreased significantly after the policy change, and this study suggests that wait times for neurosurgical procedures also significantly lengthened.
A cGMP-applicable Expansion Method for Aggregates of Human Neural Stem and Progenitor Cells Derived From Pluripotent Stem Cells or Fetal Brain Tissue (2014)

A cell expansion technique to amass large numbers of cells from a single specimen for research experiments and clinical trials would greatly benefit the stem cell community. Many current expansion methods are laborious and costly, and those involving complete dissociation may cause several stem and progenitor cell types to undergo differentiation or early senescence. To overcome these problems, we have developed an automated mechanical passaging method referred to as “chopping” that is simple and inexpensive. This technique avoids chemical or enzymatic dissociation into single cells and instead allows for the large-scale expansion of suspended, spheroid cultures that maintain constant cell/cell contact. The chopping method has primarily been used for fetal brain-derived neural progenitor cells or neurospheres, and has recently been published for use with neural stem cells derived from embryonic and induced pluripotent stem cells. The procedure involves seeding neurospheres onto a tissue culture Petri dish and subsequently passing a sharp, sterile blade through the cells effectively automating the tedious process of manually mechanically dissociating each sphere. Suspending cells in culture provides a favorable surface area-to-volume ratio; as over 500,000 cells can be grown within a single neurosphere of less than 0.5 mm in diameter. In one T175 flask, over 50 million cells can grow in suspension cultures compared to only 15 million in adherent cultures. Importantly, the chopping procedure has been used under current good manufacturing practice (cGMP), permitting mass quantity production of clinical-grade cell products.
Optimal decision strategies for acquisition of spread-spectrum signals in frequency-selective fading channels (1998)

The focus of this paper is on the initial acquisition of a direct sequence (DS) spread-spectrum signal utilizing a purely parallel search strategy. A parallel search strategy is utilized because it reduces the acquisition time compared to either serial or partially parallel strategies. In particular, the purpose of this paper is to derive the optimal decision rule, based on the maximum-likelihood criterion, for frequency-selective fading channels. The performance of the conventional decision rule, optimized for additive white Gaussian noise and flat-fading channels, the optimal decision rule derived, and a suboptimal decision rule, also presented in this paper, are compared. It is shown that the optimal and suboptimal decision rules for Rayleigh-fading channels outperform the conventional decision rule. For Rician-fading channels, it is shown both that the optimal decision rule outperforms the conventional decision rule, and that the optimum decision rule for Rayleigh-fading channels, when implemented on a Rician-fading channel, yields approximately optimum performance.
ChemInform Abstract: Synthesis of Galactose‐Terminated Oligosaccharides by Use of Glactosyltransferase. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
New Mutations in DNHD1 Cause Multiple Morphological Abnormalities of the Sperm Flagella (2023)

Male infertility is a common and complex disease and presents as a wide range of heterogeneous phenotypes. Multiple morphological abnormalities of the sperm flagellum (MMAF) phenotype is a peculiar condition of extreme morphological sperm defects characterized by a mosaic of sperm flagellum defects to a total asthenozoospermia. At this time, about 40 genes were associated with the MMAF phenotype. However, mutation prevalence for most genes remains individually low and about half of individuals remain without diagnosis, encouraging us to pursue the effort to identify new mutations and genes. In the present study, an a cohort of 167 MMAF patients was analyzed using whole-exome sequencing, and we identified three unrelated patients with new pathogenic mutations in <i>DNHD1</i>, a new gene recently associated with MMAF. Immunofluorescence experiments showed that DNHD1 was totally absent from sperm cells from <i>DNHD1</i> patients, supporting the deleterious effect of the identified mutations. Transmission electron microscopy reveals severe flagellum abnormalities of sperm cells from one mutated patient, which appeared completely disorganized with the absence of the central pair and midpiece defects with a shortened and misshapen mitochondrial sheath. Immunostaining of IFT20 was not altered in mutated patients, suggesting that IFT may be not affected by <i>DNHD1</i> mutations. Our data confirmed the importance of DNHD1 for the function and structural integrity of the sperm flagellum. Overall, this study definitively consolidated its involvement in MMAF phenotype on a second independent cohort and enriched the mutational spectrum of the <i>DNHD1</i> gene.
Management of Treatment-Resistant Schizophrenia (2012)

Schizophrenia continues to be among the most disabling disorders in psychiatry, and it often requires several attempts at treatment before finding the right regimen. Prognostic factors such as age of onset, types of symptoms, and treatment patterns can be influential in the overall outcome. The goal of treatment in schizophrenia should be to achieve recovery from the illness, beyond just amelioration of hallucinations or delusions. This often requires pharmacotherapy, nonmedication somatic therapies, psychotherapy, and other treatment modalities. Often in the course of schizophrenia, other psychiatric comorbidities are present and can influence the plan for care. For those who do not recover with the first few attempts at treatment, this chapter provides a review of evidence-based techniques and other ideas for clinicians to use with patients to achieve the best clinical response.
Does rapid microwave fixation improve immunohistochemistry? (1990)

Microwave fixation in dilute aldehyde solution has been reported to be superior to fixation in formaldehyde for the preservation of antigens. We studied antigen preservation among tissues which were soaked in formaldehyde, dilute aldehyde, alcohol, and saline solution with or without microwave irradiation. Microwave fixation was found to be superior to conventional formaldehyde fixation with regard to antigen preservation. However, there was no detectable difference in immunostaining between any of the irradiated and nonirradiated alcohol-, aldehyde-, or even saline-treated tissues. Microwave-irradiated tissues, regardless of the fixative employed, displayed a tendency for tissue disintegration upon protease treatment, as is commonly seen in alcohol-fixed tissues. Our results suggest that the apparent improvement in antigen preservation when microwave fixation in dilute aldehyde solution is used is largely attributable to the fixation in alcohol during the graded alcohol dehydration steps in the tissue processor, rather than to any demonstrable effect of the microwave radiation per se.
ADVANCED CFD AND MODELING OF ACCIDENTAL EXPLOSIONS (2003)

▪ Abstract This paper reviews the current state of the art in accidental explosion modeling using methods based on computational fluid dynamics (CFD) in the petrochemical process industries. We discuss the problem in terms of its industrial importance and its technical difficulty, which stems mainly from the large range of length and timescales that must be represented. Explicit representation of all scales is not feasible due to limitations of computational cost, and modeling of unresolved physical features is required. We also discuss geometry modeling using the porosity/distributed resistance (PDR) method and review relevant combustion modeling. We describe an advanced CFD approach using unstructured adaptive gridding and discuss its usefulness in the context of results obtained for both two dimensional and three dimensional simulations of gas explosion phenomena in complex geometries.
Excited state properties of C 60 revisited: a Raman study (2003)

The excited state properties of C<sub>60</sub> thin films have been probed in the temperature range 77-273K using Raman spectroscopy. The change in the Raman pentagonal pinch mode of C<sub>60</sub> (whose position is largely independent of temperature) was monitored as a function of the excitation intensity at 514.5nm. This mode, normally positioned at 1469cm<sup>-1</sup>, was seen to shift reversibly to a lower Raman frequency with increasing laser intensity. Two excited state species have been identified. The first, at 1466cm<sup>-1</sup> has been associated with the molecular triplet of C<sub>60</sub> as determined from measurements preformed in solution. The second species at 1463cm<sup>-1</sup>, has been speculated to be an excited state co-operative involving two or more excited states in the solid and is seen to be intrinsic to solid state C<sub>60</sub> below the phase transition, as similar measurements in solution show no Raman evolution beyond 1466cm<sup>-1</sup>. This species observed at 1463cm<sup>-1</sup> has previously been reported in the depolymerisation of solid state C<sub>60</sub>, as well as in reversible processes in C<sub>60</sub> crystals and has been characterised by a nonlinear photo-luminescence and photoconductivity. It is further proposed in this study that this excited state is analogous to a number of highly conducting states recently reported for C<sub>60</sub>. The data presented highlights the existence of a highly non-linear delocalised excited state species at low temperatures which is intrinsic to solid state C<sub>60</sub>.