gebhart/patrepeval huggingface dataset:
Effects of heated-water immersion exercise in blood arterial pressure (2021)

Introduction : Hypertension (HTN) is considered a public health problem associated with high risk for cardiovascular morbidity and mortality.HTN treatment includes lifestyle modifications.Cardiovascular disease risk may be reduced by physical exercise, which promote acute and chronic reductions on blood arterial pressure (BAP).Moderate intensity land-based exercise training (walking, cycling, running) is commonly recommended for hypertensive patients.The aquatic environment provides important physiological alterations.Water immersion exercise has been shown to promote important cardiovascular and muscular benefits.In this context, heated water-based exercise has emerged as an approach to reduce BAP in hypertensive patients.Objective: to know the effects of water immersion exercise in blood arterial pressure.Methods : a bibliographic review on PubMed, Scopus and Scielo about the effects of water immersion exercise in BAP.Results and Discussion : There are several physiological mechanisms triggered by the aquatic environment which benefits the neurohumoral control of BAP.They may be influenced by different factors such as physical properties of water (heat, hydrostatic pressure), exercise protocols, muscle mass.Conclusions : the results suggest that a training period of heated water-based exercise appears to reduce BAP and could have potential as a therapeutic approach to hypertensive patients.However, due to the variety of exercise frequency, duration and intensity, as well as due to the studied population included in the different studies, the magnitude and duration of acute and chronic hypotensive effect ranged substantially.
Molecular regulations governing TREK and TRAAK channel functions (2011)

K+ channels with two-pore domain (K2p) form a large family of hyperpolarizing channels. They produce background currents that oppose membrane depolarization and cell excitability. They are involved in cellular mechanisms of apoptosis, vasodilatation, anesthesia, pain, neuroprotection and depression. This review focuses on TREK-1, TREK-2 and TRAAK channels subfamily and on the mechanisms that contribute to their molecular heterogeneity and functional regulations. Their molecular diversity is determined not only by the number of genes but also by alternative splicing and alternative initiation of translation. These channels are sensitive to a wide array of biophysical parameters that affect their activity such as unsaturated fatty acids, intra- and extracellular pH, membrane stretch, temperature, and intracellular signaling pathways. They interact with partner proteins that influence their activity and their plasma membrane expression. Molecular heterogeneity, regulatory mechanisms and protein partners are all expected to contribute to cell specific functions of TREK currents in many tissues.
Effect of inhaled morphine on the development of breathlessness during exercise in patients with chronic lung disease. (1996)

In patients with severe chronic lung disease inhaled morphine in the doses used in this study does not relieve exercise induced breathlessness nor does it increase maximum power output achieved during progressive exercise.
The iC3b Receptor on Candida albicans: Subcellular Localization and Modulation of Receptor Expression by Glucose (1990)

Patient isolates of Candida albicans from blood, urine, or mucosal sites express a surface receptor for C3 fragment iC3b that is recognized by monoclonal antibodies (MAb) directed against alpha-chain epitopes of the neutrophil iC3b receptor, also known as the type 3 complement receptor (CR3) or CD11b/CD18. Because 60% of these patients were hyperglycemic, the effect of glucose on receptor expression was investigated. As assessed by flow cytometry, yeasts grown in 20 mM D-glucose exhibited a four- to six-fold increase in receptor expression compared with yeasts grown in 20 mM L-glutamate. Receptor expression increased as glucose concentration rose from 0 to 20 mM (equivalent to plasma glucose concentrations of 0-360 mg/dl). Augmentation of receptor expression by growth in glucose led to significant inhibition of phagocytosis compared with that of organisms grown in equimolar L-glutamate. SDS-PAGE, Western blotting, and immunodetection of extracts of yeast cell wall, membrane, and cytosol disclosed a protein of 165 kDa in membrane and cytosolic extracts, consistent with the published Mr of the alpha-chain of neutrophil CR3. These studies provide a mechanism to explain the predilection of C. albicans to infect the hyperglycemic host.
Automatic Liver and Tumor Segmentation of CT and MRI Volumes using Cascaded Fully Convolutional Neural Networks (2017)

Automatic segmentation of the liver and hepatic lesions is an important step towards deriving quantitative biomarkers for accurate clinical diagnosis and computer-aided decision support systems. This paper presents a method to automatically segment liver and lesions in CT and MRI abdomen images using cascaded fully convolutional neural networks (CFCNs) enabling the segmentation of a large-scale medical trial or quantitative image analysis. We train and cascade two FCNs for a combined segmentation of the liver and its lesions. In the first step, we train a FCN to segment the liver as ROI input for a second FCN. The second FCN solely segments lesions within the predicted liver ROIs of step 1. CFCN models were trained on an abdominal CT dataset comprising 100 hepatic tumor volumes. Validations on further datasets show that CFCN-based semantic liver and lesion segmentation achieves Dice scores over 94% for liver with computation times below 100s per volume. We further experimentally demonstrate the robustness of the proposed method on an 38 MRI liver tumor volumes and the public 3DIRCAD dataset.
Intracranial hemorrhage in acute coronary syndrome: incidence, predictors, and outcomes from APPRAISE-2, PLATO, and TRACER (2013)

Purpose/Methods: We pooled patient-level data from cohorts with non–ST-segment elevation acute coronary syndromes (NSTE ACS) from 3 antithrombotic therapy trials to evaluate intracranial hemorrhage (ICH). Multivariable modeling identified independent predictors of ICH. Results: Of 31,416 patients included, 108 (0.3%) had an ICH. The median follow-up was 332 (184, 434) days but differed across trials. Those with ICH were older (median 69 vs 65 years), more often had history of prior transient ischemic attack (TIA)/stroke (15% vs 8%), and had higher median baseline systolic blood pressure (SBP) (137 vs 130 mmHg). Locations of ICH were intracerebral (59%), subdural (9%), subarachnoid (9%), and intraventricular (10%). Of all ICH events, 47 (43%) were associated with death, which occurred within 30 days in 40 (85%) cases. Predictors of ICH are listed, and a Kaplan-Meier curve is displayed. Independent predictors of ICH Conclusion: In these trials, ICH was uncommon. Patients with older age, higher SBP, and prior TIA/stroke were at increased risk. ICH was associated with high mortality, and the risk increased over time. Integrating biomarker and genetic data is required to perhaps better identify ACS patients at risk of ICH.
Synthesis and Properties of 1,2,3-Triethoxypropane: A Glycerol-Derived Green Solvent Candidate (2020)

Etherification with high selectivity and yield has been one of the challenges for expanding the realm of glycerol transformations. In this work, a small glycerol triether molecule, 1,2,3-triethoxypropane (1,2,3-TEP, CAS 162614-45-1), was designed and synthesized through a two-step strategy using epichlorohydrin as the starting material with ethanol and bromoethane as etherification reagents. The overall yield (after rigorous distillation) was 43.9%, higher than those of methods previously published in the literature. Thermophysical properties for 1,2,3-TEP are herein reported for the first time. Densities and viscosities measured at 1 atm from 20 to 80 °C show that 1,2,3-TEP is a less dense and less viscous liquid than glycerol and the corresponding 1,3-diether intermediate, 1,3-diethoxypropan-2-ol (1,3-DEP, CAS #4043-59-8). CO2 solubility in 1,2,3-TEP was investigated under pressures of 2–8 atm at 30, 45, 60, and 75 °C with respective KH values of 46.2, 57.4, 69.4, and 81.7 atm, enabling reliable predictions on CO2 solubility within this range of temperature and pressure conditions. Comparison of Henry’s law constants and vapor pressure between 1,2,3-TEP and diglyme from 0 to 75 °C has indicated its potential as an alternative CO2 capture solvent to those used in the Selexol process. 1,2,3-TEP showed broad miscibility with common solvents except water. The dipole moment of the minimum energy structure in the gas phase is calculated to be 1.47 D, but this value increases to 2.5–2.7 D in common solvents. The data obtained in this work are meaningful in guiding the further synthesis of a series of glycerol triether derivatives and developing uses for 1,2,3-TEP and related compounds.
Novel Mouse Model of Monocular Amaurosis Fugax (2007)

Background and Purpose— Retinal ischemia is a major cause of visual impairment and is associated with a high risk of subsequent ischemic stroke. The retina and its projections are easily accessible for experimental procedures and functional evaluation. We created and characterized a mouse model of global and transient retinal ischemia and provide a comprehensive chronologic profile of some genes that display altered expression during ischemia. Methods— Ischemia and reperfusion were assessed by observing flat-mounted retinas after systemic fluorescein injection. The temporal pattern of gene expression modulation was evaluated by quantitative reverse transcription–polymerase chain reaction from the occurrence of unilateral 30-minute pterygopalatine artery occlusion until 4 weeks after reperfusion. Electroretinograms evaluated functional sequelae 4 weeks after the ischemic episode and were correlated with histologic lesions. Results— This model is the first to reproduce the features of transient monocular amaurosis fugax resulting from ophthalmic artery occlusion. The histologic structure was roughly conserved, but functional lesions affected ganglion cells, inner nuclear layer cells, and photoreceptor cells. We observed an early and strong upregulation of c -fos , c -jun, Cox-2, Hsp70 , and Gadd34 gene expression and a late decrease in Hsp70 transcript levels. Conclusions— A murine model of transient retinal ischemia was successfully developed that exhibited the characteristic upregulation of immediate-early genes and persistent functional deficits. The model should prove useful for investigating mechanisms of injury in genetically altered mice and for testing novel neuroprotective drugs.
Cyclotagitinin C and its transformations (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCyclotagitinin C and its transformationsPritish K. Chowdhury, Nabin C. Barua, Ram P. Sharma, Jogendra N. Barua, Werner Herz, Kinzo Watanabe, and John F. BlountCite this: J. Org. Chem. 1983, 48, 5, 732–738Publication Date (Print):March 1, 1983Publication History Published online1 May 2002Published inissue 1 March 1983https://doi.org/10.1021/jo00153a023RIGHTS & PERMISSIONSArticle Views146Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (908 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Drug CRL 40 028-induced inhibition of pancreatic secretion in rats. (1983)

The drug CRL 40 028 increases spontaneous motility through an action on central adrenergic receptors. The effects of this drug have been tested in rats on the external pancreatic secretion induced by secretin, CCK, acetylcholine, vagal electrical stimulation or 2 deoxy-D-glucose. CRL 40 028 had no effect on basal secretion nor on secretion stimulated by agents acting directly on pancreatic secretory cells (secretin, CCK, acetylcholine), but decreased significantly secretion induced by central or peripheral stimulation of the vagus nerves. CRL 40 028-induced inhibition of 2 DG effect was reduced by yohimbine, suggesting a participation of alpha 2-adrenergic receptors in the action of CRL 40 028 on the exocrine pancreas secretion of rats.
Parameters estimation for underwater Doppler signal using unscented Kalman filter (2013)

Doppler processing techniques can be used to estimate the parameters of line-spectrum acoustic sources of an underwater target with constant velocity. Previous estimation methods are based on observed frequency or phase which describes the time varying Doppler shift. Because of the low-frequency and low-speed characteristics of underwater line-spectrum noise source, the Doppler shift is very tiny and can hardly be detected accurately. It is difficult to estimate the parameters by the previous approaches. A method of underwater Doppler signal parameters estimation based on the unscented Kalman filter is presented in this paper. The signal and measurement systems are placed into state-space form, therefore allowing the unknown parameters of the signal model to be estimated. As a result, the accurate estimation of instantaneous frequency can be avoided. Simulation results are presented to demonstrate the feasibility of the proposed method.
Hexagonal uniformly redundant arrays for coded-aperture imaging (1985)

Uniformly redundant arrays are used in coded-aperture imaging, a technique for forming images&#13;\nwithout mirrors or lenses. This technique is especially important for the high energy x-ray&#13;\nand y-ray region above 20 keV. In this technique, a mask consisting of opaque (closed) and transparent&#13;\n(open) areas is placed between the photon sources to be imaged and a position sensitive&#13;\ndetector or a detector array. Each source casts a shadow pattern of the mask or aperture onto the&#13;\ndetector. This shadow pattern may be viewed as an encoded signal for that source direction. If&#13;\neach possible source code is unique, the detected composite of overlapping shadow patterns may&#13;\nbe decoded to produce an image of the source distribution.
A New Stereoselective Method for Developing Ring a of Podocarpic Acid Compounds (1972)

Abstract A veriety of syntheic approaches to diterpens resin acids have been reported recently. Stereoselective syntheses of resin acids related to poducarpic acid(1) have been accomplished by Meyer and Maheshwari1, Giarrusso and Ireland2, Kuehne and Nelsor3, Mori and Matsui4, Spencer and Coworker5and also by Pelletier and coworkers6. Likewise, stereoselective syntheses of resin acids related to abietic acid(2)have beer achieved by Stork and Schulenberg7, Ireland and Kierstead, and coworkers,11
Sonochemistry (2005)

Abstract Acoustic Cavitation Two‐Site Model of Sonochemical Reactivity Microjet Formation during Cavitation at Liquid–Solid Interfaces Sonoluminescence Sonochemistry
Viral nervous necrosis (VNN) in white seabass, Atractoscion nobilis, cultured in Southern California, and implications for marine fish aquaculture (2003)

The organism responsible for causing viral nervous necrosis (VNN) or viral encephalopathy and retinopathy (VER) has been demonstrated to belong to the group Nodaviridae [K. Mori, et al., 1992] [M. Comps, et al., 1994]. Since its initial identification in 1990 by Yoshikoshi and Inoue (1990), in Japanese parrotfish, its distribution and/or identification has become global. Methods of identification developed and results from outbreaks of VNN in white seabass between 1992 and 1999 have been published in Curtis et al. (2001). The white seabass cultured at the Hubbs-SeaWorld Research Institute's hatchery in Carlsbad California (CBD), have experienced VNN, of varying severity, since 1992. Disease in 1992 was thought to be due to a picrona-like virus but the indirect fluorescent antibody technique (IFAT) performed in 1999 on samples from 1992, indicated the same nodavirus was responsible. Confirmation of the nodavirus in white seabass was done using IFAT, reverse transcription-polymerase chain reaction (RT-PCR), electron microscopy and virus isolation via cell culture. The strain of nodavirus isolated from white seabass was shown to be similar to that recovered from redspotted grouper in Japan. The most serious and extensive outbreak experienced in white seabass at CBD extended from August of 2002 to May 2003. Since 1999 a concerted effort has been made to further the understanding of VNN epidemiology in white seabass. Recently, enzyme linked immunosorbant assays (ELISA) performed on sera samples from wild fish have demonstrated VNN exposure in wild juvenile white seabass. With the apparent lack of species specificity of VNN and its global distribution, continued devastating impacts on new marine species development are a distinct possibility. Along with cooperative measures for identification and epidemiology, there needs to be a drive towards development of preventative husbandry protocols and methods of prophylaxis.
A stabilization method for speed sensorless vector controlled induction motors at zero frequency operating condition with multirate adaptive observer (2005)

This paper proposes a stabilization method for speed sensorless vector controlled induction motors at zero frequency operating condition using a new configuration of the adaptive observer. In speed sensorless vector controlled induction motors, it has been pointed out that the speed identification system becomes unstable at zero frequency operating condition. This problem is caused by lack of the knowledge of the rotor side of induction motors, and the disturbance such as a parameter mismatch of the stator quantities at zero frequency operating condition. In this paper, a new configuration of the adaptive observer, which stabilizes speed sensorless vector control of induction motors without injecting a high frequency or an excitation signal, is proposed. Firstly, causes of unstable speed identification in the conventional speed sensorless vector control system are considered. Next, a configuration of the adaptive observer based on multirate control in order to stabilize the speed sensorless system at zero frequency operating condition is proposed. Finally, validity of the proposed method is shown by experimental results.
Organic Vanadium Compounds - Transition State Analogy with Organic Phosphorus Compounds (1996)

Vanadium compounds, particularly in oxidation state V, are potent inhibitors of phosphoryl group transfer enzymes. In this paper the existance of a correlation between the coordination geometry of a series of vanadium dipicolinate complexes and their potency as inhibitors for chicken intestinal alkaline phosphatase is examined. We find that within a limited series of vanadium compounds the five-coordinate derivatives are the most potent inhibitors.
Test-retest reliability of myofascial trigger point detection in patients with rotator cuff tendonitis (2005)

The presence or absence of the taut band, spot tenderness, jump sign and pain recognition was highly reliable between sessions. Referred pain and local twitch response reliability varied depending on the muscle being studied.
Change Detection Analysis of Humans Moving Behind Walls (2013)

In this paper, we consider the problem of detection of humans behind walls and inside enclosed structures using radars. We use change detection techniques to mitigate the heavy clutter caused by strong reflections from exterior and interior walls. To improve spatial resolution, we apply multiple-input multiple-output (MIMO) configurations to moving target indication (MTI). We examine change detection formulation and performance when clutter removal is performed pre- and postbeamforming. Using signal multiplexing from two transmitters and several receiver positions, we show that the virtual array (coarray) implementing the prebeamforming change detection MIMO scheme permits enhanced clutter rejection and improvement in imaging resolution of moving targets without increasing the physical aperture. Laboratory experiments are conducted to validate the proposed approaches with targets walking behind walls.
A hollow stainless steel microneedle array to deliver insulin to a diabetic rat (2016)

A novel fabrication process has been described for the development of a hollow stainless steel microneedle array using femto second laser micromachining. Using this method, a complicated microstructure can be fabricated in a single process step without using masks. The mechanical stability of the fabricated microneedle array was measured for axial and transverse loading. Skin histology was carried out to study the microneedle penetration into the rat skin. Fluid flow through the microneedle array was studied for different inlet pressures. The packaging of the microneedle array, to protect the microneedle bore blockage from dust and other atmospheric contaminations, was also considered. Finally, the microneedle array was tested and studied in vivo for insulin delivery to a diabetic rat. The results obtained were compared with the standard subcutaneous delivery with the same dose rate and were found to be in good agreement.
Issues of predicting performance of thermosyphon heat exchangers (1996)

Determination of the performance of indirect solar heating systems that use thermosyphon heat exchangers requires knowledge of how thermosyphon flow rate and heat exchanger performance vary with operating conditions. In this paper, measured performance of a two-pass, tube-in-shell, double-wall heat exchanger is presented and discussed in terms of modeling issues. The inadequacy of using a simple temperature difference to predict thermosyphon flow rate is illustrated. Accuracy of prediction of thermosyphon flow rate from a pressure balance on the water loop depends on the accuracy of assumed temperature distributions in the heat exchanger and tank. For a given collector flow rate, heat exchanger performance depends on natural convection heat transfer coefficient and temperature of the antifreeze fluid and is not uniquely determined by thermosyphon flow rate. Models based on the assumption that for a given collector flow rate, overall heat transfer coefficient-area product or effectiveness of the heat exchanger are determined by thermosyphon flow rate may produce erroneous predictions of system performance.