gebhart/patrepeval huggingface dataset:
Handover Control in MBMS Enabled 3G Mobile Cellular Networks (2007)

Handover control in a cellular infrastructure aims to provide continuity of mobile services to a user traveling over cell boundaries. Using the existing Handover control algorithm in 3rd generation (3G) mobile cellular networks supporting multicast and broadcast multimedia services (MBMS) might prove inefficient due to the new aspects introduced. In this paper we investigate and highlight the inefficiencies caused when a PMM (packet mobility management)-connected mobile user is receiving an MBMS service and performs a handover using the existing handover approach. We therefore propose and evaluate a specific MBMS handover approach to address the issues highlighted in our analysis.
UCE6, a New Antitumor Antibiotic with Topoisomerase I-mediated DNA Cleavage Activity Produced by Actinomycetes: Producing Organism,Fermentation, Isolation and Biological Activity. (1997)

A novel antitumor antibiotic, UCE6 (1,3,8,10,11-pentahydroxy-2-methyl-10-(2-oxo-4-hydroxypentyl)na phthacene-5, 12-dione) with topoisomerase I-mediated DNA cleavage activity, was isolated from the culture broth of actinomycetes strain UOE6. Addition of silicone oil antifoam agent, KS69 (2%), to the fermentation enhanced the production of UCE6 by approximately 3 fold. A total of 1.15 g of UCE6 was recovered as reddish orange crystals from a 100 liter fermentation supplemented with 2% KS69. UCE6 exhibited growth inhibitory activity against HeLa S3, HCT116 and Lu-65 cells comparable to that of camptothecin.
In vitro fertilization and alternatives (1981)

PERHAPS as many as 500,000 American women are infertile as a result of Fallopian tube dysfunction. Because this represents an important national health problem, work in our laboratory has focused on novel approaches to alleviate such infertility, using nonhuman primate experimental models. The rationale for pursuing new experimental methods, as well as a summary of recent findings, may be of interest to medical practitioners treating and counseling such patients, as well as to infertility specialists in reproductive medicine. At the outset, it may be enlightening to compare the current situation in the treatment of women with irreparably blocked or missing Fallopian tubes with the major advances that have occurred during the past 20 years in the treatment of infertility resulting from anovulation. Principally, achievements in ovulation induction are the result of having developed four remarkably effective medicinal agents, acting either through the CNS (especially hypothalamic-pituitary centers) or within the ovaries
Solution of the Kalman filtering problem for stationary noise and finite data records (1979)

A solution is obtained in the s-domain to the finite-time optimal filtering problem where the system is constant and the noise is stationary. This enables the time-varying Kalman filter gain matrix to be calculated using transform techniques. In the solution of this problem, to find the optimal time-varying linear filter, a new fixed point filtering problem is posed and solved. That is, the optimal time-invariant filter is found which will give the best state estimate after some fixed time interval T. This state estimate is the same as would be obtained from the equivalent Kalman filter at this time. It follows that this time-invariant filter can give a better state estimate than the Wiener filter, when the filtering time is finite Sub-optimal versions of both the time-invariant filter and the Kalman filter are defined from a simple approximation which can be made in the s-domain solution. This considerably simplifies the calculation of the gain matrix for the continuous-time Kalman filter. There are important advantages over the Kalman filter in the implementation of both the time-invariant filter and the sub-optimal filters.
Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood (2016)

Cytotoxic T lymphocyte antigen-4 (CTLA-4) is essential for immunological (self-) tolerance, but due to the early fatality of CTLA-4 KO mice, its specific function in central and peripheral tolerance and in different systemic diseases remains to be determined. Here, we further examined the role of CTLA-4 by abrogating CTLA-4 expression in adult mice and compared the resulting autoimmunity that follows with that produced by congenital CTLA-4 deficiency. We found that conditional deletion of CTLA-4 in adult mice resulted in spontaneous lymphoproliferation, hypergammaglobulinemia, and histologically evident pneumonitis, gastritis, insulitis, and sialadenitis, accompanied by organ-specific autoantibodies. However, in contrast to congenital deficiency, this was not fatal. CTLA-4 deletion induced preferential expansion of CD4(+)Foxp3(+) Treg cells. However, T cells from CTLA-4-deficient inducible KO mice were able to adoptively transfer the diseases into T cell-deficient mice. Notably, cell transfer of thymocytes de novo produced myocarditis, otherwise not observed in donor mice depleted in adulthood. Moreover, CTLA-4 deletion in adult mice had opposing impacts on induced autoimmune models. Thus, although CTLA-4-deficient mice had more severe collagen-induced arthritis (CIA), they were protected against peptide-induced experimental autoimmune encephalomyelitis (EAE); however, onset of protein-induced EAE was only delayed. Collectively, this indicates that CTLA-4 deficiency affects both central and peripheral tolerance and Treg cell-mediated suppression.
Effect of single ventricular premature contractions on response to cardiac resynchronization therapy (2022)

In patients undergoing CRT implantation, lower number of PVCs predicted atrial remodeling and showed a trend for a better mortality outcome. Our results suggest the importance of the early assessment of PVCs in cardiac resynchronization therapy and warrant further investigations.
Evaluating a Text-to-Scene Generation System as an Aid to Literacy (2011)

We discuss classroom experiments using WordsEye, a system for automatically generating 3D scenes from English textual descriptions. Input is syntactically and semantically processed to identify a set of graphical objects and constraints which are then rendered as a 3D scene. We describe experiments with the system in a summer literacy enrichment program conducted at the Harlem Educational Activities Fund with 6th grade students, in which students using the system had significantly greater improvement in their literary character and story descriptions in pre- and post- test essays compared with a control. Students reported that using the system helped them imagine the events in the stories they were reading better. We also observed that social interaction engendered by this process was a strong motivator.
Polarization in the quasielastic scattering of 1-GeV/c protons on light nuclei (2000)

Polarization measurements in the A(p, 2p)B reactions on 6Li, 7Li, and 28Si nuclei at a proton-beam energy of 1 GeV were performed in a kinematically complete experiment. By using a two-arm magnetic spectrometer, two secondary protons were recorded in coincidence at asymmetric scattering angles of θ1=15°−26° and θ2=58.6° for residual-nucleus momenta in the range K B=0–150 MeV/c. Either arm of the spectrometer was equipped with polarimeters based on proportional chambers. The data coming from this experiment are analyzed within the distorted-wave impulse approximation. It is shown that the polarization of recoil protons formed at angle θ2 in the interaction featuring a proton from the P shell of the 7Li nucleus can be described under the assumption of an effective intranuclear-proton polarization by using the single-particle shell-model wave function of the nucleus. Our data on the polarizations of the two protons from the reaction (p, 2p) on a 28Si nucleus also suggest the effective polarization of the protons in the D shell of the 28Si nucleus. It is found that, for high recoil-nucleus momenta of K B≥90 MeV/c, the effective polarization of the protons in the P shell of the 6Li nucleus—this polarization was discovered in studying the polarization of recoil protons in the reaction 6Li(p, 2p)5He—cannot be described within the shell model assuming LS coupling. As might have been expected, the polarization of recoil protons knocked out from the S shells of the 6Li and 7Li nuclei comply well with the predictions obtained in the impulse approximation with allowance for the depolarization effect alone.
Preliminary x‐ray analysis of Escherichia coli GMP synthetase: Determination of anomalous scattering factors for a cysteinyl mercury derivative (1994)

We have initiated a project to determine the three-dimensional structure of GMP synthetase (GMPS) from Escherichia coli. GMPS catalyzes the conversion of XMP to GMP in the final step of de novo guanine nucleotide biosynthesis, and is a member of the glutamine amidotransferase family: a group of enzymes responsible for the assimilation of nitrogen into compounds such as amino acids, purine and pyrimidine bases, amino sugars, and antibiotics. The E. coli guaA gene encoding GMPS was cloned into a tac expression vector, overexpressed, and its gene product purified. Conditions for the growth of protein crystals were developed using recombinant GMPS in the presence of MgCl2, ATP, and XMP. The crystals are monoclinic, space group P2(1), with cell parameters of a = 156.0 A, b = 102.0 A, c = 78.8 A, beta = 96.7 degrees. Diffraction data to 2.8 A spacings were collected on a Xuong-Hamlin area detector with an overall Rsym of 5.2%. Both the volume of the unit cell and the peaks in the self-rotation function are consistent with one GMPS tetramer of D2 symmetry in the crystallographic asymmetric unit. Previously, GMPS has been observed only as a dimer in solution. GMPS was covalently modified with p-chloromercuribenzylsulfonic acid (PCMBS), and its X-ray fluorescence spectrum was measured through the LIII absorption edge of mercury. Anomalous scattering factors for cysteinyl mercury were derived from this spectrum, and the feasibility of structure determination by multi-wavelength anomalous diffraction was evaluated. The optimal MAD dispersive signal is 4.5% of magnitude of F, and the optimal MAD Bijvoet signal is 7.5% of magnitude of F at a concentration of approximately 1 mercury per 10-kDa protein. The anomalous scattering factors tabulated here should be transferable to cysteinyl mercury in other proteins.
A new digital recursive filter structure based on delta modulation encoding (2003)

It is pointed out that conventional digital filters, in which signal samples and filter coefficients are represented by 8- to 16-bit words, have some advantages for VLSI implementation due to the high hardware complexity of multibit multipliers. Incremental digital filters, based on delta modulation (DM) encoding, having emerged as a promising alternative to the conventional approach, because highly modular 'multiplier-free' structures can be built using incremental methods. A multiplier-free biquad filter structure is proposed which is suitable for VLSI implementation with low roundoff noise and low limit cycle operations.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Model Testing of Ridge Keel Loads on Structures Part II: Ridge Building and Physical Properties (2009)

As part of model testing of ice ridge loads on subsea structures, four ridges were built in the Hamburg Ship Model Basin (HSVA) during November 2008. Two different kinds of ridges were used, referred as cold and warm ridges. This paper presents the way in which the ridges were built along with its physical properties: ridge profiles, block size, porosity, temperature evolution, consolidated layer, hardness of rubble blocks, freeze bond strength and ice properties. On one hand, this paper aims to inform the reader about the physical characteristics of the model ridges that are important to understand their mechanical behavior. On the other hand, it compares and critically evaluates the different available methods to evaluate the coldness of the model ridges and studies how these properties vary for warm and cold ridges.
Task Versus Vehicle-Based Control Paradigms in Multiple Unmanned Vehicle Supervision by a Single Operator (2014)

There has recently been a significant amount of activity in developing supervisory control algorithms for multiple unmanned aerial vehicle operation by a single operator. While previous work has demonstrated the favorable impacts that arise in the introduction of increasingly sophisticated autonomy algorithms, little work has performed an explicit comparison of different types of multiple unmanned vehicle control architectures on operator performance and workload. This paper compares a vehicle-based paradigm (where a single operator individually assigns tasks to unmanned assets) to a task-based paradigm (where the operator generates a task list, which is then given to the group of vehicles that determine how to best divide the tasks among themselves.) The results demonstrate significant advantages in using a task-based paradigm for both overall performance and robustness to increased workload. This effort also demonstrated that while previous video gaming experience mattered for performance, the degree of experience that demonstrated benefit was minimal. Further work should focus on designing a flexible automated system that allows operators to focus on a primary goal, but also facilitate lower level control when needed without degradation in performance.
Through-air drying of tissue and towel grades (1999)

A computer model that simulates the sheet drying part of through-air drying of tissue and towel grades has been developed. Empirical relationships for heat and mass transfer coefficients show that a simple, single relationship covering a wide range of through-drying conditions is not adequate. However, several empirical relationships, each covering a narrow range of process conditions, are more accurate. Experimental data that represent commercial operating conditions are critical in developing a comprehensive system simulation. Results to date indicate that, under the conditions studied, the sheet temperature quickly warms up to the saturation temperature and remains constant for a long time before beginning to rise at the end. The sheet drying rate primarily consists of an increasing rate period and a falling rate period. Application : a computer model could be used to evaluate ways to reduce energy consumption in new through-drying systems.
Mechanical White Blood Cell Damage in Rotary Blood Pumps (1997)

Mechanical trauma of white blood cells (WBC) due to the operation of a rotary blood pump was examined, using a simple method of trypan blue dye exclusion test for a cell viability measurement. The degree of WBC trauma was investigated using a roller pump (RP) and 3 commercially available centrifugal pumps (Bio-Medicus [BP], Capiox [CP], Nikkiso [NK]), and compared with the red blood cell (RBC) trauma. Each pump was operated 3 times at a flow rate of 5 L/min against the total pressure head of 350 mm Hg for 6 h in a mock circuit with 400 ml of fresh bovine blood. Blood was sampled at 2 h intervals measuring plasma free hemoglobin concentration and the percentage of damaged WBC in the trypan blue dye exclusion test. Each pump demonstrated a linear increase in the degree of WBC trauma, and there were differences among the tested pumps (RP > BP > CP > NK). These findings were similar to those of the free hemoglobin measurements. To compare the degree of RBC and WBC trauma, the probability (gamma, omega) of RBC and WBC to be damaged was calculated, respectively. gamma = delta DRBC/delta N, omega = delta DWBC/delta N where DRBC and DWBC are the ratios of the damaged RBC and WBC, respectively, and N is the passing number defined as Qt/V (Q, flow rate; t, time; V, circulating volume). The data of this study demonstrated that the omega value was approximately 20 times or more greater than the gamma equally in all the tested pumps. This suggests that a WBC is more vulnerable to mechanical damage by a rotary blood pump than a RBC.
The Pile: An 800GB Dataset of Diverse Text for Language Modeling (2020)

Recent work has demonstrated that increased training dataset diversity improves general cross-domain knowledge and downstream generalization capability for large-scale language models. With this in mind, we present \textit{the Pile}: an 825 GiB English text corpus targeted at training large-scale language models. The Pile is constructed from 22 diverse high-quality subsets -- both existing and newly constructed -- many of which derive from academic or professional sources. Our evaluation of the untuned performance of GPT-2 and GPT-3 on the Pile shows that these models struggle on many of its components, such as academic writing. Conversely, models trained on the Pile improve significantly over both Raw CC and CC-100 on all components of the Pile, while improving performance on downstream evaluations. Through an in-depth exploratory analysis, we document potentially concerning aspects of the data for prospective users. We make publicly available the code used in its construction.
Supplementary Table S5 from Real-world Studies Link NSAID Use to Improved Overall Lung Cancer Survival (2023)

&lt;p&gt;Supplementary Table 5: The MD Anderson and Georgetown cohorts 5-year survival rates and differences of 5-year restricted mean survival time in months between NSAID users and non-users for all patients and by stage and histopathology corresponding to Figure 1. The abbreviations are AD (adenocarcinoma) and SCC (squamous cell cancer), respectively.&lt;/p&gt;
Silicon-Atom Induced Fermi-Level Pinning of Fully Silicided Platinum Gates on HfO2 Dielectrics (2005)

Fully silicided platinum gates have been proposed as metal gate electrodes for scaled complementary metal oxide semiconductor field-effect transistors (CMOSFETs). The Pt monosilicide (PtSi) phase was formed on gate dielectrics by a full silicidation reaction at 400°C. PtSi gate electrodes on SiO 2 possess a high effective work function of 4.9 eV, which could be used as a possible metal gate electrode for p-MOSFETs, while at the PtSi/HfO 2 interface, Fermi-level pinning is observed independent of the PtSi fabrication process. The Fermi-level pinning at the PtSi/HfO 2 interface is comparable to that at the poly-Si/HfO 2 interface, and Fermi-level pinning does not occur at the Pt/HfO 2 interface. These results show that Fermi-level pinning is induced by the presence of silicon atoms at the HfO 2 upper interface.
Resolution of Multiple Ribonucleic Acid Species by Polyacrylamide Gel Electrophoresis* (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTResolution of Multiple Ribonucleic Acid Species by Polyacrylamide Gel Electrophoresis*Andrew C. Peacock and C. Wesley DingmanCite this: Biochemistry 1967, 6, 6, 1818–1827Publication Date (Print):June 1, 1967Publication History Published online1 May 2002Published inissue 1 June 1967https://pubs.acs.org/doi/10.1021/bi00858a033https://doi.org/10.1021/bi00858a033research-articleACS PublicationsRequest reuse permissionsArticle Views499Altmetric-Citations640LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Electrically conductive pili from pilin genes of phylogenetically diverse microorganisms (2017)

The possibility that bacteria other than Geobacter species might contain genes for electrically conductive pili (e-pili) was investigated by heterologously expressing pilin genes of interest in Geobacter sulfurreducens. Strains of G. sulfurreducens producing high current densities, which are only possible with e-pili, were obtained with pilin genes from Flexistipes sinusarabici, Calditerrivibrio nitroreducens and Desulfurivibrio alkaliphilus. The conductance of pili from these strains was comparable to native G. sulfurreducens e-pili. The e-pili derived from C. nitroreducens, and D. alkaliphilus pilin genes are the first examples of relatively long (>100 amino acids) pilin monomers assembling into e-pili. The pilin gene from Candidatus Desulfofervidus auxilii did not yield e-pili, suggesting that the hypothesis that this sulfate reducer wires itself with e-pili to methane-oxidizing archaea to enable anaerobic methane oxidation should be reevaluated. A high density of aromatic amino acids and a lack of substantial aromatic-free gaps along the length of long pilins may be important characteristics leading to e-pili. This study demonstrates a simple method to screen pilin genes from difficult-to-culture microorganisms for their potential to yield e-pili; reveals new sources for biologically based electronic materials; and suggests that a wide phylogenetic diversity of microorganisms may use e-pili for extracellular electron exchange.
Bile acids, farnesoid X receptor, atherosclerosis and metabolic control (2007)

Farnesoid X receptor represents a potentially attractive target for treatment of various aspects of the metabolic syndrome and for prevention of atherosclerosis. Yet, in view of its pleiotropic effects and apparent species-specificity, it is evident that successful interference of the farnesoid X receptor signalling system will require the development of gene-specific and/or organ-specific farnesoid X receptor modulators and extensive testing in human models of disease.
Developmental regulation of embryonic genes in plants (1988)

Somatic embryogenesis from cultured carrot cells progresses through successive morphogenetic stages termed globular, heart, and torpedo. To understand the molecular mechanisms underlying plant embryogenesis, we isolated two genes differentially expressed during embryo development. The expression of these two genes is associated with heart-stage embryogenesis. By altering the culture conditions and examining their expressions in a developmental variant cell line, we found that these genes were controlled by the developmental program of embryogenesis and were not directly regulated by 2,4-dichlorophenoxyacetic acid, the growth regulator that promotes unorganized growth of cultured cells and suppresses embryo morphogenesis. These genes are also expressed in carrot zygotic embryos but not in seedlings or mature plants.