gebhart/patrepeval huggingface dataset:
Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice (2010)

IgE-mediated hypersensitivity is central to the pathogenesis of asthma and other allergic diseases. Although neutralization of serum IgE with IgE-specific antibodies is in general an efficacious treatment for allergic asthma, one limitation of this approach is its lack of effect on IgE production. Here, we have developed a strategy to disrupt IgE production by generating monoclonal antibodies that target a segment of membrane IgE on human IgE-switched B cells that is not present in serum IgE. This segment is known as the M1' domain, and using genetically modified mice that contain the human M1' domain inserted into the mouse IgE locus, we demonstrated that M1'-specific antibodies reduced serum IgE and IgE-producing plasma cells in vivo, without affecting other immunoglobulin isotypes. M1'-specific antibodies were effective when delivered prophylactically and therapeutically in mouse models of immunization, allergic asthma, and Nippostrongylus brasiliensis infection, likely by inducing apoptosis of IgE-producing B cells. In addition, we generated a humanized M1'-specific antibody that was active on primary human cells in vivo, as determined by its reduction of serum IgE levels and IgE plasma cell numbers in a human PBMC-SCID mouse model. Thus, targeting of human IgE-producing B cells with apoptosis-inducing M1'-specific antibodies may be a novel treatment for asthma and allergy.
Browsers with changing parts (2000)

The development of navigational tools for a web site devoted to a catalog of musical compositions offers a variety of design challenges. A combination of techniques developed from information visualization research - including starfield displays, dynamic queries, and zoomable user interfaces (ZUIs) - was used to construct a prototype browser for possible use in a web site dedicated to the work of Philip Glass. After a discussion of the goals and potential users of the site, this paper describes several prototypes that were developed and how they informed the design of a zoomable starfield browser. Unresolved design challenges and possibilities for future work are also discussed.
X-ray pulse shaping from tungsten-based multi-planar wire arrays (2011)

Summary form only given. An exploration of the shaping of x-ray radiation pulses from tungsten-based multi-planar wire array (PWA) z-pinch implosions carried out on a 1.7 MA, 110 ns university-scale generator is discussed, and an investigation of their radiative properties and implosion dynamics is performed. The experiments were performed on Zebra, the pulse power generator located at the University of Nevada, Reno, with data collected using a full suite of diagnostics that include x-ray diodes, extreme ultraviolet (EUV) diodes, optical imaging, shadowgraphy, time-gated and time-integrated x-ray pinhole imagers, time-gated, spatially integrated x-ray and EUV spectrometers, time-integrated, spatially resolved soft and hard x-ray spectrometers, and a Faraday cup. Three load types that showed particularly diverse and useful results are explained in detail. The first consists of double planar wire arrays built from two planes of wires of different materials, specifically tungsten and another lower-Z element such as aluminum. The second are triple planar loads, which consist of three parallel planes of wires. Like double planar loads, pulse shaping with triple planar arrays could be varied by using alternate wire materials, but an analysis of uniform loads in which the mass of the center array was significantly different from that of the outer arrays showed particularly interesting results. Third, we investigate the pulse shaping of skewed wire arrays. These arrays are similar to standard double planar wire arrays, but the wires in parallel rows are set at an angle opposing one another. These three load configurations were used to create a diverse set of pulse shapes, including pre-pulses of various intensities prior to the main x-ray burst, and “steps” on the front of the main pulse. The possible application of these results to inertial confinement fusion and radiation physics experiments is also discussed.
Regioselective monometalation of 2,5‐pyridinedicarboxamides with (2,2,6,6‐tetramethylpiperidino)magnesium chloride (TMPMgCI) (1995)

Abstract The 2,5‐pyridinecarboxamides 9–15 were synthesized in one or two steps from diester 1 by addition of an excess of dimethylaluminium amide or successive addition of two different dimethylaluminium amides with or without intermediate workup. For the carboxamides 16 and 17 this method failed; they were, however, available by other procedures. Metalation of the carboxamides 9–17 with TMPMgCI and subsequent reaction with electrophiles led to the 2,3,5‐ and 2,4,5‐substituted pyridines 9a/b‐17a/b, 18 and 19 with regioselectivities ranging from predominant 4‐substitution to complete 3‐substitution.
C-Nucleophilic Substitution of 5-Halo-1,2,3-thiadiazoles as an Approach to Fused Pyridones and Pyranones (1997)

E. V. Tarasov, Y. Yu. Morzherin, S. Toppet, W. Dehaen and V. A. Bakulev, J. Chem. Res. (S), 1997, 396 DOI: 10.1039/A703631K
Minimally Invasive Retrieval of Knotted Nonstimulating Peripheral Nerve Catheters (2007)

The knotting of peripheral nerve catheters is a relatively uncommon phenomenon, occurring in only 0.13% of patients. However, because the use of perineural catheters has increased within anesthesia practice, clinicians may begin to encounter these complications with greater frequency. Practitioners should be aware of surgical alternatives, including guided-fluoroscopic techniques, when simple catheter traction or tension proves unsuccessful at the patient bedside.
SODIUM BICARBONATE AND THE MICROSTRUCTURE, EXPANSION AND COLOR OF EXTRUDED BLACK BEANS (2005)

Seed microstructure provides complementary information to physicochemical determinations. Scanning electron micrographs of cross sections of black bean extrudates illustrated the increase in volume expansion, with an increase of sodium bicarbonate (NaHCO 3 ) in the extrudate. This increase in volume expansion is attributed to the increase in air cell size and corresponding decrease in air cell wall thickness with additional concentrations of NaHCO 3 . The measured increase in diameter and expansion ratio of extrudates with NaHCO 3 addition may be explained by the increase in number of air cells within the extrudate and the increase in pores in the gelatinized starch matrix of air cell walls. Extrusion conditions, which involved the use of heat and moisture, provided the necessary conditions for the release of CO 2 from NaHCO 3 during processing. Expansion ratio increases between the control extrudate, and extrudate with 0.5% NaHCO 3 addition were twofold at the node and 1.8-fold at the area between the nodes. Statistical analysis of color data exhibited no significant change in L*, hue or chroma across concentrations of NaHCO 3 for nonextruded flours. A simple linear regression adequately described changes in L* and hue for extruded flours. However, a curvilinear relationship was needed to explain changes in chroma versus NaHCO 3 for extruded flours, making changes in chroma measurements less easy to interpret. The color data in this study serve as primary information for future establishment of cut-off values of color for the development of an acceptable legume snack.
Nesne Tanma ve Yerseme ic ‚in ¤ Uretimsel Bir Model (2005)

In this study, a generative model which performs not only image labelling according to the object categories present in the images but also patch labelling which aims to locate the object in the image is proposed.
Research and implementation of business logic customization framework for SaaS applications (2011)

SaaS is a global rise of innovative software service model.It appearance has a profound impact on the informationization of small and medium enterprises. Currently, the techniques and methods for online business logic customization of SaaS applications are complex,and the contents that can be customized are limited.To solve these problems, this paper proposed a flexible business logic customization framework for SaaS applications, using domain engineering based business rule template approach. Both of the usability and performance were taken into account. Finally an example has been conducted to show the effectiveness of the framework.
Patch antenna miniaturization using thick truncated textured ceramic substrates (2004)

The recent availability of high-contrast, low-loss ceramic materials provides us with possibilities for significant antenna miniaturization. The paper explores the use of low temperature cofired ceramic substrates in producing a miniaturized patch antenna design. Of particular concern in the design are substrate thickness, impedance matching, radiation efficiency and bandwidth due to the high-contrast ceramic. We propose a thick substrate to increase bandwidth. However, the substrate is truncated and/or modified to mitigate surface wave loss. Also, a textured substrate is proposed for dielectric constant control and for improved impedance matching. Gain measurements are given along with the analysis. Further, the effect of the finite ground plane is examined. The paper provides both return loss and overall gain calculations and measurements.
Airway Area by Acoustic Reflection: A Corrected Derivation for the Two-Microphone Method (1999)

A corrected derivation is provided for the relationship between the impulse response of a wave tube termination and pressure signals measured at two different locations within the tube. This derivation yields exactly the same final result as was reported previously by Louis et al. (1993), despite the omission of the active source term in that earlier derivation. This technique has become the basis of an important medical diagnostic technology. This report revises and corrects the earlier theory upon which that technology rests.
Experimental Investigation of Relative Permeability Upscaling from the Micro-Scale to the Macro-Scale (2001)

During this reporting period, achieved the milestone of using Optical Coherence Imaging (OCI) to image to the back of the first layer of grains in a sandstone sample. This was the first time that OCI was used to image through sandstone. Information on grain geometry was obtained as deep as 400 microns into the sample. This report also describes the work performed to achieve the milestone on the measurement of interfacial area per volume, capillary pressure and saturation in two dimensional micromodels structures that are statistically similar to real porous media. This report contains the first quantitative experimental measurements of interfacial area per volume in any system.
Incorporating Time–Dose–Response Into Shigella flexneri and Shigella sonnei Outbreak Models (2017)

Experimental time‐to‐infection data are a useful but often underused material for examining the mechanics of in vivo pathogen growth. The authors incorporated a time–dose–response (TDR) equation into a Shigella flexneri outbreak model. Dose–response and TDR models were generated for Shigella sonnei outbreak model. Dose–response and TDR models were generated for S. flexneri exposure to monkeys. The TDR equation that best fit the monkey data—the beta‐Poisson with exponential dependency model—was chosen for incorporation into the outbreak model. The outbreak model is a probability model that convolutes an assumed incubation distribution of the infectious agent with an exposure distribution. Since the beta‐Poisson with exponential dependency models the time‐to‐infection density distribution, it is entered as the incubation distribution, along with Weibull, lognormal, gamma, and uniform functions. Each of these five incubation functions is convoluted with Weibull, lognormal, gamma, and uniform functions (which served as exposure distributions) for a total of 20 models. The time‐dependent probability distribution yielded best‐fit results for the S. sonnei outbreak scenario.
New Immobilized Enzyme Membranes for Tailor-Made Biosensors (1986)

Abstract Commercially available polyamide preactivated membranes for immunodiagnostic use were found suitable for the preparation of immobilized enzyme membranes adaptable to biosensors. Membranes with immobilized glucose oxidese as model enzyme, tested with a microprocessor-based device involving an enzymatic electrode, gave excellent results. The extremely simple and fast procedure allows anyone to prepare such bioactive membranes easily, possibly from his own enzyme preparation and within a few minutes set up a specific probe from commercially available sensors.
Azathioprine Is Superior to Budesonide in Achieving and Maintaining Mucosal Healing and Histologic Remission in Steroid-Dependent Crohnʼs Disease (2008)

In patients with steroid-dependent inflammatory Crohn's ileocolitis or proximal colitis who achieve clinical remission with conventional steroids, a 1-year treatment with AZA was superior to BUD in achieving and maintaining mucosal healing and histologic remission.
Role of periodontal pathogenic bacteria in RANKL-mediated bone destruction in periodontal disease (2010)

Accumulated lines of evidence suggest that hyperimmune responses to periodontal bacteria result in the destruction of periodontal connective tissue and alveolar bone. The etiological roles of periodontal bacteria in the onset and progression of periodontal disease (PD) are well documented. However, the mechanism underlying the engagement of periodontal bacteria in RANKL-mediated alveolar bone resorption remains unclear. Therefore, this review article addresses three critical subjects. First, we discuss earlier studies of immune intervention, ultimately leading to the identification of bacteria-reactive lymphocytes as the cellular source of osteoclast-induction factor lymphokine (now called RANKL) in the context of periodontal bone resorption. Next, we consider (1) the effects of periodontal bacteria on RANKL production from a variety of adaptive immune effector cells, as well as fibroblasts, in inflamed periodontal tissue and (2) the bifunctional roles (upregulation vs. downregulation) of LPS produced from periodontal bacteria in a RANKL-induced osteoclast-signal pathway. Future studies in these two areas could lead to new therapeutic approaches for the management of PD by down-modulating RANKL production and/or RANKL-mediated osteoclastogenesis in the context of host immune responses against periodontal pathogenic bacteria.
Precipitation Kinetics and Mechanism in Cu-7 wt% Ag Alloy (2011)

The discontinuous precipitation kinetics and mechanism of the α (Ag-rich) phase in Cu-7 wt% Ag alloy has been investigated using dilatometric and calorimetric anisothermal analysis, optical microscopy, scanning and transmission electron microscopy and X-ray diffraction. Dilatometric and calorimetric curves present at ~ 500°C an important effect related to the ? (Ag-rich) phase formation and consequently the matrix β (Cu-rich) depletion. The nucleation and growth of the precipitated phase show cells formation at initial grain boundaries; a fine lamellar structure is detected by SEM and TEM and consists of alternate lamellar of the α (Ag-rich) and β (Cu-rich)-solid solutions. Cellular precipitation leads to the simultaneous appearance of two diffraction peaks and occurs apparently according to the Fournelle and Clark’s mechanism. Obtained results give an Avrami exponent n = 2.0 ± 0.2 in agreement with an interfacial controlled process having an activation energy Ea equals to 99 ± 7 kJ/mol obtained from anisothermal analysis by using different isoconversion methods. This activation energy expresses the discrepancy between isoconversion methods and the analytical diffusive model. Moreover, the supersaturation rate has an effect on the lamella spacing of the precipitated cells.
Design and additive manufacture for flow chemistry (2013)

We review the use of additive manufacturing (AM) as a novel manufacturing technique for the production of milli-scale reactor systems. Five well-developed additive manufacturing techniques: stereolithography (SL), multi-jet modelling (MJM), selective laser melting (SLM), laser sintering (LS) and fused deposition modelling (FDM) were used to manufacture a number of miniaturised reactors which were tested using a range of organic and inorganic reactions.
IDO1 Activity Predicts Lung Toxicity in Patients with Unresectable Stage III NSCLC and Chemoradiotherapy (2023)

High baseline IDO1 activity combined with unfavorable baseline FEV1 was predictive of severe RILT in unresectable stage III NSCLC patients. IDO1 might play a role in the acute inflammatory response. Finding effective interventions to alleviate RILT using IDO inhibitors is warranted in the future.
Expression of Programmed Death 1 Ligand in Different Compartments of Chronic Lymphocytic Leukemia (2015)

PD-L1 expression is shared between CLL cells localized in distinct disease compartments, demonstrating that PD-1/PD-L1 a universal target for therapy.
An Extended AODV Protocol for VoIP Application in Mobile Ad Hoc Network (2007)

In this paper, the problem of voice calls over a mobile ad hoc network that employs IEEE 802.11b standard for the lowest communication layer is considered. The Distributed Coordination Function (DCF) is assumed as the basic medium access protocol. Two DCF access mechanisms for VoIP conversation are considered. A new metric for searching a stable routing based on an extended Ad-hoc On-Demand Distance Vector (AODV) protocol is proposed and investigated. The simulation results show that the new routing protocol can improve performance of VoIPover ad hoc network as compared to the standard AODV protocol.
Joint Nonanticipative Rate Distortion Function for a Tuple of Random\n Processes with Individual Fidelity Criteria (2021)

The joint nonanticipative rate distortion function (NRDF) for a tuple of\nrandom processes with individual fidelity criteria is considered. Structural\nproperties of optimal test channel distributions are derived. Further, for the\napplication example of the joint NRDF of a tuple of jointly multivariate\nGaussian Markov processes with individual square-error fidelity criteria, a\nrealization of the reproduction processes which induces the optimal test\nchannel distribution is derived, and the corresponding joint NRDF is\ncharacterized. The analysis of the simplest example, of a tuple of scalar\ncorrelated Markov processes, illustrates many of the challenging aspects of\nsuch problems.\n
The antigenic and immunosuppressive properties of normal and antilymphocytic equine IgG subfractions. (1973)

The antigenic and immunosuppressive properties of normal and antilympho-cytic equine globulin subfractions were investigated in the rat model in an attempt to increase the efficacy of prolonged ALG therapy by limiting the immunogenic stimulus of `inactive' subfractions. Chromatographic separation of equine IgG components yielded an electro-phoretically slow gamma 2 fraction consisting of IgG2a and IgG2b and a more heterogeneous fast gamma 1 subfraction. Immunosuppression resulting from the administration of isolated subfractions was measured by the response to alum-BSA and skin allograft survival. Antigenicity was determined by a variety of immunological procedures. The immunosuppressive character of the ALG was confined to the gamma 2 fraction, however this fraction also proved antigenic in our system. The administration of normal equine IgG subfractions in combination with Freund's complete adjuvant resulted in the demonstration of antigenic differences between the fast and slow IgG components.
An Internet-Wide View of Connected Cars: Discovery of Exposed Automotive Devices (2022)

As the number of connected cars increases, cyber-attacks targeting them become significant risks. Especially, On-Board Equipment (OBE) that is directly accessible from the Internet can be an immediate target. However, it is not known what kind of and how many connected automotive devices can be remotely accessed from the Internet and, if compromised, become an entry point for further attacks on in-vehicle networks. In this study, we investigate the prevalence of such exposed vehicular devices. We propose a discovery method that utilizes an Internet-wide scan engine and a regular web search engine to find Internet-facing OBE. Using the proposed method, we discovered 2,532 devices of 12 different OBE products across 27 countries. We also investigated the potential cyber-attack risks against the discovered devices. 11 out of the 12 products have security concerns for remote compromises, such as running Telnet or outdated server programs. Moreover, we found that nine products have the capability to connect to the in-vehicle network. We could confirm from the information displayed in their user interface that at least two of them indeed connected to the in-vehicle network. Additionally, we noticed three products expose privacy-sensitive information such as GPS location. We believe this result provides a lower bound of the security risk of Internet-facing vehicular devices.
Real-Time Communications in the Web: Issues, Achievements, and Ongoing Standardization Efforts (2012)

Web Real-Time Communication (WebRTC) is an upcoming standard that aims to enable real-time communication among Web browsers in a peer-to-peer fashion. The IETF RTCWeb and W3C WebRTC working groups are jointly defining both the APIs and the underlying communication protocols for setting up and managing a reliable communication channel between any pair of next-generation Web browsers.
Silicon photonic mode multiplexers based on subwavelength metamaterials and on-chip beamforming (2023)

Integration of photonic circuits on silicon offers a unique opportunity to address the scaling of inter- and intra-chip communications in an energy-efficient and cost-effective manner. Mode-division multiplexing (MDM) is deemed as one of the most promising technologies to increase aggregated data bandwidth and avoid a communication capacity crunch. In this invited talk, we review our latest advances on integrated silicon mode multiplexers, including new topologies based on subwavelength grating (SWG) metamaterials for extended broadband operation and higher-order mode support. Specifically, we report on an ultra-broadband multiplexer based on a phase shifter and a multimode interference (MMI) coupler both engineered with subwavelength metamaterials. Experimental measurements of a complete multiplexer-demultiplexer link show losses lower than 2 dB and crosstalk below -17 dB over a bandwidth of 245 nm (1427 – 1672 nm).
A novel ring-based EPON architecture (2005)

Ethernet passive optical network (EPON) has drawn considerable research attention in recent years. EPON can be implemented in different topologies in access network environment. Recently, the tree topology was the focus of the researchers. In this paper, we propose a cost effective novel ring-based EPON architecture with associated dynamic bandwidth allocation (DBA) algorithm as an alternative to standard EPON architectures. This architecture, compared with conventional ring, allows optical line terminal (OLT) receiver to function with narrower dynamic range through minimization of near-far problem. In addition, the proposed DBA algorithm outperforms other DBA algorithms proposed in the literature. This proposed architecture is proved to be fault-tolerant and cost effective. Furthermore, this novel approach also has the potential of inter-optical network units (ONU) connectivity, which can bring LAN support in access environment