gebhart/patrepeval huggingface dataset:
Bidirectional Three-Phase LLC Resonant Converter (2018)

Resonant circuit has been widely implemented to achieve high conversion efficiency by means of soft switching for the power transistor. In bidirectional converter application, the most commonly implemented resonant converter is series resonant converter due to its natural capability for bidirectional power flow operation, simple operation, and simple design. However, a series resonant converter operating gain range is limited to maximum at unity, resulting in difficulty maintaining output voltage for bidirectional operation. To improve the output voltage regulation for bidirectional operation, LLC resonant tank was selected as interesting alternative to SRC resonant tank. Using LLC resonant tank in bidirectional converter application requires two different operation modes depending on the direction of power flow. For forward power flow operation, the converter operates with switching frequency lower than the resonant frequency to achieve boost mode operation (Gain > 1). For reverse power flow operation, the converter will operate at switching frequency higher than its resonant frequency to achieve buck mode operation (Gain <; 1). To increase the power handling capability, three resonant tanks are utilized together to form a three-phase resonant converter. In the end, a 400V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">IN</sub> /400 V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">OUT</sub> 8 kW working prototype was built to verify design feasibility. From the experimental measurement, peak efficiency of over 96% for both power flow operation was achieved.
COMPLETE PHALLOPLASTY WITH A PRELAMINATED OSTEOCUTANEOUS FIBULA FLAP (1997)

No AccessJournal of UrologyClinical Urology: Case Reports1 Dec 1997COMPLETE PHALLOPLASTY WITH A PRELAMINATED OSTEOCUTANEOUS FIBULA FLAP Carl C. Capelouto, Dennis P. Orgill, and Kevin R. Loughlin Carl C. CapeloutoCarl C. Capelouto , Dennis P. OrgillDennis P. Orgill , and Kevin R. LoughlinKevin R. Loughlin View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)68213-2AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "COMPLETE PHALLOPLASTY WITH A PRELAMINATED OSTEOCUTANEOUS FIBULA FLAP." The Journal of Urology, 158(6), pp. 2238–2239 References 1 : Review of the literature on techniques for phalloplasty with emphasis on the applicability in female-to-male transsexuals.. J. Urol.1993; 150: 1093. Abstract, Google Scholar 2 : Penile reconstruction using the lateral arm flap.. J. Roy. Coll. Surg. Edinburgh1987; 32: 97. Google Scholar 3 : Penile prosthesis implantation in total phalloplasty.. J. Urol.1994; 152: 410. Abstract, Google Scholar 4 : One-stage total penile reconstruction with a free sensate osteocutaneous fibula flap.. Plast. Reconstr. Surg.1993; 92: 1314. Google Scholar 5 : Ankle instability of the donor site following removal of vascularized fibula bone graft.. Ann. Plast. Surg.1990; 24: 7. Google Scholar From the Divisions of Urology and Plastic Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.Accepted for publication May 23, 1997.© 1997 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 158Issue 6December 1997Page: 2238-2239 Advertisement Copyright & Permissions© 1997 by American Urological Association, Inc.MetricsAuthor Information Carl C. Capelouto More articles by this author Dennis P. Orgill More articles by this author Kevin R. Loughlin More articles by this author Expand All Advertisement PDF downloadLoading ...
Identification of the Vibrational Optical Coherence Tomography Corneal Cellular Peak (2023)

This work furthers our understanding of the origin of the corneal ≤100 Hz peak identified using VOCT.
Hospital arrival times and post-imaging delays in stroke thrombolysis implementation (2017)

Background: Rapid alteplase delivery for ischemic stroke patients has been shown to increase the likelihood of disability-free life. Identification of barriers to rapid alteplase delivery and streamlining processes around imaging assessments are important. Our aim was to examine the relationships between hospital arrival time and postimaging processes in stroke thrombolysis. Methods: De-identified data of patients who underwent intravenous alteplase therapy at 20 hospitals in Australia were entered into the Thrombolysis ImPlementation in Stroke (TIPS) audit tool. During the pre-intervention phase, 601 patients who received alteplase ≤ 270 minutes of stroke onset were analysed. Onset-to-door (OTD), door-to-needle (DTN), door-to-imaging (DTI), and imaging-to-needle (ITN) times were assessed using univariable and multivariable linear regression analyses. Results: The age was 71.3 ± 13.4years, and the median NIHSS score was 11. The median OTD, DTN, DTI, ITN times were 73, 85, 32, and 46 minutes, respectively. Every minute earlier of OTD resulted in 0.24 minutes slower DTN (p&lt;0.01), 0.06 minutes slower DTI (p=0.02), and 0.17 minutes slower ITN times (p&lt;0.01). Every point decrease of baseline NIHSS score resulted in 0.66 minutes slower DTN (p =0.01) and 0.47 minutes slower DTI (p =0.01), however ITN had no significant association with baseline NIHSS score. Conclusions: Early arrival time was a greater contributor to delayed treatment, in particular post-imaging processes compared with pre-imaging processes, in patients with alteplase therapy for ischemic stroke. Improved processes to reduce post-imaging delays are needed for rapid alteplase treatment.
Linear Microphone Array Parallel to the Driving Direction for in-Car Speech Enhancement (2023)

This paper proposes a linear microphone array parallel to the driving direction for in-car speech enhancement. In contrast to other linear microphone arrays in the car cabin reported in a literature or implemented as a commercial product, the array axis is arranged in parallel to the driving direction. Thanks to the 90°-rotated array axis with the constraints on the microphone position specific to the car environment, a mirror image of the directivity toward the talker with respect to the array axis is no longer projected in the direction of interference and redirected to a direction with no interference. As a result, the talker speech can be discriminated from the interference by directivity, leading to good interference reduction with little speech distortion. Simulation results with signals recorded in a car environment show that the proposed linear microphone array with the array axis parallel to the driving direction has a null in the direction of interference, which leads to 13% higher word accuracy than the conventional microphone array with the array axis perpendicular to the driving direction.
Development of a Comprehensive Virtual Training Package for Power Plant Boiler (2013)

As one of the most important components in coal-fired power station, the operators and maintenance crews of boiler systems receive comprehensive training in unit operation procedures and emergency preparedness. Due to the inaccessibility of the field environment, the majority of the training sessions take place in a classroom using 2D presentation materials such as pictures, drawings, etc. In order to provide a more efficient training program, a software package for power plant boilers was developed through the integration of Computational Fluid Dynamics (CFD) and Virtual Reality (VR) visualization. Using numerical simulation data, the package creates a computer-generated boiler in which the users can observe the actual phenomenon in an easily-understood context. It also allows instructors and trainees to selectively explore various components, operating conditions and scenarios using the built-in Graphic User Interface (GUI). This training package enables people who are unfamiliar with boiler operations to gain better understanding in much less time.
The Unsteady Flow Physics of Hypersonic Inlet Starting Processes (2012)

A 2D numerical investigation was undertaken utilising transient, time-accurate, RANS computational fluid dynamics, with the aim of investigating the influence of viscous and unsteady effects when attempting to start a hypersonic scramjet inlet. A variable geometry inlet starting mechanism incorporating sliding doors was utilised, with the two doors initially extending upstream from the scramjet leading edge. After establishing a steady-state solution, the doors were retracted up and over the inlet and the resulting flow field captured. A started flow regime was achieved only when retracting the doors at such a speed (0.1ms total retraction time) that at no point could quasi-steady Kantrowitz assumptions be applied to the internal flow field. Viscous effects were seen to play a significant role in the inlet starting process, with unstart being obtained earlier for lower Reynolds number conditions. Shockwave boundary layer interactions (SWBLI) were found to be the key driver behind inlet unstart.
Porous PZT with tailored ultrasonic properties (2009)

For many years, PZT has been the most important piezoelectric ceramic for commercial applications. The well-known soft and hard PZT types are obtained by doping with various elements, but especially mechanical and acoustic properties cannot be altered significantly by slight modifications of the composition. However, the invention of PZT with controlled porosity has greatly extended the range of properties that can be obtained. The introduction of porosity into the structure affects all properties, and by optimising composition, porosity level and pore size it has proved possible to design materials that can replace especially lead metaniobate-based ceramics for a number of applications. The new materials combine properties normally associated with lead metaniobate, e.g. low acoustic impedance, with the well-known virtues of PZT, such as high piezoelectric coupling coefficients and the possibility to adjust the dielectric constant and the mechanical quality factor by doping. The porous PZT materials have been tested commercially and examples of specific applications are given.
SHERLOC: A phase 2 study of MM-121 plus with docetaxel versus docetaxel alone in patients with heregulin (HRG) positive advanced non-small cell lung cancer (NSCLC). (2019)

9036 Background: Seribantumab (MM-121) is a human monoclonal IgG2 antibody that blocks the HRG domain of HER3. Preclinical data suggest that seribantumab reverses HRG mediated drug resistance across multiple cancer models. In prior retrospective analyses, addition of seribantumab to standard of care (SOC) appeared to improve outcomes in pts with HRG+ tumors. Here we tested if seribantumab plus SOC improved progression-free survival (PFS) in pts with HRG+ lung adenocarcinoma who had received prior platinum-based therapy. Methods: SHERLOC was a randomized, open-label, multicenter, Phase 2 study in pts with advanced HRG+ adenocarcinoma of the lung. Archival or pre-treatment tumor samples were assessed for HRG+ by RNA in situ hybridization. Eligibility criteria included prior platinum-based therapy for advanced disease with ≤ 2 total prior lines of therapy (prior IO was allowed) and no EGFR or ALK mutations. Pts were randomized 2:1 to receive seribantumab 3000 mg/docetaxel 75 mg IV q3w (experimental; exp) or docetaxel 75 mg IV q3w alone (control). Primary endpoint was PFS. Key secondary endpoints were overall survival (OS), objective response rate (ORR), and adverse event (AEs) profile. Results: At a pre-specified interim analysis of 75% of total PFS events, 108 pts were enrolled (exp n = 71, control n = 37). Median age was 62y (range 34-83y); female 34%; one prior treatment only 39%. Median PFS was 3.0m for exp and 4.0m for control, HR = 1.66m (p = 0.084). Median OS was 7.9m for exp and 8.4m for control, HR = 1.50 (p = 0.235). ORR was 19.7% for exp and 5.6% for control (p = 0.052). Serious AEs were more frequent in the exp arm (40.8%) vs control (24.3%). Most common treatment emergent AEs (TEAEs) in the exp arm were diarrhea (47%), fatigue (37%), and neutropenia (27%). Based on a determination of futility at interim analysis, the study was terminated early. Conclusions: Seribantumab failed to improve PFS when added to docetaxel among previously treated advanced HRG+ NSCLC pts. A higher response rate and a higher incidence of TEAEs were observed in the exp arm. No further study of seribantumab is planned in NSCLC. Clinical trial information: NCT02387216.
Population of higher-energy levels in LiY 1 - x Er x F 4 (x=0.003/1) crystals under CW IR laser-diode pumping (2002)

Steady-state population of 7 lowest excited erbium levels in LiY<SUB>1-x</SUB>Er<SUB>x</SUB>F<SUB>4</SUB> (YLF:Er<SUP>3+</SUP>) crystals was studied under up conversion CW InGaAs laser-diode pumping with varied power density. Theoretical and experimental concentration and power dependencies of population of higher-energy radiative levels were obtained. Relative changes in populations of studied levels in YLF:Er<SUP>3+</SUP> crystals were experimentally controlled by visible spectra of steady-state luminescence in the wavelength ranges corresponding to transitions <SUP>4</SUP>S<SUB>3/2</SUB> yields <SUP>4</SUP>I<SUB>15/2</SUB> micrometers and <SUP>4</SUP>F<SUB>9/2</SUB> yields <SUP>4</SUP>I<SUB>15/2</SUB> micrometers . IR-pumped luminescence kinetic curves of higher-energy transitions <SUP>4</SUP>S<SUB>3/2</SUB> yields <SUP>4</SUP>I<SUB>15/2</SUB> and <SUP>2</SUP>H<SUB>9/2</SUB> yields <SUP>4</SUP>I<SUB>15/2</SUB> were recorded. The energy-transfer mechanisms were determined, and the predominant mechanisms responsible for up conversion excitation were elucidated. Microparameters of energy transfer and concentration dependencies of the self-quenching rates and non-linear coupling were obtained on the basis of theoretical and experimental estimates of the rates of intra- and intercenter relaxation processes allowing for statistics of coupling between the impurity centers in the system. The steady-state dependencies of population on the erbium concentration and pumping power density were calculated within the framework of rate balance equations. Good agreement between the theory and experimetnal data was obtained.
Board Structure, Capital Structure and Dividend Per Share: Is there Interaction Effect? (2014)

This study examines the direct effects of firm�s characteristics such as board structure and capital structure on divided per share as a proxy of firm�s performance and interaction between board structure and capital structure on dividend. The fixed effect regression uses a sample of 361 non-financial Malaysian listed firms over the period of 2002 to 2007. The decision made by the board of directors with duality role of Chairman cum Chief Executive Officer and larger board size to pay dividend demonstrates that duality role of chairman cum chief executive officer have negative effect on dividend payment but not outside independent director(s). The interaction between board structure namely duality, independent directors, board size and capital structure namely debt ratio reveals that duality weakens the negative effect of debt ratio on dividend while independent directors strengthens the negative effect of debt ratio on dividend payment. Overall, the results of this study may be summarized to suggest that distributable income to shareholders increases through a balanced financing decision between capital structure choice and dividend payment made by the board of directors that possessed duality role.
A comparison of word graph and n-best list based confidence measures (1999)

In this paper we present and compare several confidence measures for large vocabulary continuous speech recognition.We show that posterior word probabilities computed on word graphs and N-best lists clearly outperform non-probabilistic confidence measures, e.g. the acoustic stability and the hypothesis density.In addition, we prove that the estimation of posterior word probabilities on word graphs yields better results than their estimation on N-best lists and discuss both methods in detail.We present experimental results on three different corpora, the English NAB '94 20k development corpus, the German VERBMOBIL '96 evaluation corpus and a Dutch corpus, which has been recorded with a train timetable information system in the ARISE project.
Further load reductions with individual pitch control (2005)

Previous work has demonstrated that significant reductions in fatigue loading on a wind turbine can be achieved by using individual pitch control, in which the pitch of each blade is adjusted individually, in response to measured loads. The asymmetrical out-of-plane rotor load is measured and an additional pitch action (dominated by the rotational frequency of the rotor) is calculated for each blade in order to minimize this load. This results in the near-elimination of the dominant once-per-revolution (‘1P’) peak in the out-of-plane load spectrum seen by the rotating components, and fatigue loads can be reduced by 20%–40%. The load reduction is also transferred to the nacelle and tower, but here it is the low-frequency loads which are removed, resulting in a load reduction of a few per cent at best, since the fatigue on the fixed components is dominated by the peak at the blade passing frequency (‘3P’ for a three-bladed turbine), which is largely unaffected by the individual pitch control action. This article demonstrates a relatively straightforward addition to the individual pitch control algorithm which is capable of reducing the dominant load peak on the fixed components, resulting in significant fatigue load reductions on the whole structure. Copyright © 2005 John Wiley & Sons, Ltd.
Liquid Phase Electroepitaxial (LPEE) Growth and Photoluminescence Characterization of Undoped GaInAsSb (2.25μm) at 530°C (2005)

Liquid Phase Electroepitaxial (LPEE) layers have been successfully grown on
Optical and adhesive properties of dust deposits on solar mirrors and their effects on specular reflectivity and electrodynamic cleaning for mitigating energy-yield loss (2014)

Large-scale solar plants are mostly installed in semi-arid and desert areas. In those areas, dust layer buildup on solar collectors becomes a major cause for energy yield loss. Development of transparent electrodynamic screens (EDS) and their applications for self-cleaning operation of solar mirrors are presented with a primary focus on the removal dust particles smaller than 30 µm in diameter while maintaining specular reflection efficiency &lt; 90%. An EDS consists of thin rectangular array of parallel transparent conducting electrodes deposited on a transparent dielectric surface. The electrodes are insulated from each other and are embedded within a thin transparent dielectric film. The electrodes are activated using three-phase high-voltage pulses at low current (&lt; 1 mA/m<sup>2</sup> ). The three-phase electric field charges the deposited particles, lifts them form the substrate by electrostatic forces and propels the dust layer off of the collector’s surface by a traveling wave. The cleaning process takes less than 2 minutes; needs energy less than 1 Wh/m<sup>2</sup> without requiring any water or manual labor. The reflection efficiency can be restored &gt; 95% of the original clean-mirror efficiency. We briefly present (1) loss of specular reflection efficiency as a function of particle size distribution of deposited dust, and (2) the effects of the electrode design and materials used for minimizing initial loss of specular reflectivity in producing EDS-integrated solar mirrors. Optimization of EDS by using a figure of merit defined by the ratio of dust removal efficiency to the initial loss of specular reflection efficiency is discussed.
The XCALIBUR Project, A Natural Language Interface to Expert Systems and Data Bases (2018)

The inevitable proliferation of expert systems underscores the need for robust, friendly interfaces requiring minimal user training. The objective of the XCALIBUR project is to meet this need by providing natural comprehension and generation in the context of a focused mixed-initiative dialog. The XCALIBUR architecture is discussed, including its three central components (parser, generator and information manager), its methods of handling ellipsis and imperfect input, and its relation to the underlying expert system.
China’s Legal Issues in the Access and Benefit-sharing of the Genetic Resources (2018)

In China, genetic resources is a relatively new legal term, and the system of access and benefit-sharing of biological genetic resources is also an important task of the leading group of legislative work led by the Ministry of Environment in recent years. The genetic resources are of significant economic and strategic importance to China. China urgently needs to establish an access and benefit-sharing system for genetic resources and related traditional knowledge, and then devote itself to the development and protection of biological genetic resources. This article introduces the overall legislative model and status quo of China’s genetic resources, and discuss the legal issues in China’s current access and benefit-sharing of genetic resources.
A multicenter randomized phase II study of NPC-1C (N) in combination with gemcitabine (G) and nab-paclitaxel (A) versus G and A alone in patients with metastatic or locally advanced pancreatic cancer (PC) previously treated with folfirinox (F). (2015)

TPS499 Background: PC carries a poor prognosis. F has improved overall survival (OS) compared to G leading to its use as a 1st line treatment for patients (pts) with advanced PC. Similarly, the combination of G and A has demonstrated OS benefit. No data exists for G/A in the 2nd line setting. Many oncologists continue to sequence F treatment followed upon disease progression by G/A for pts with advanced PC with good performance status. N is a chimeric monoclonal IgG1 antibody recognizing an aberrantly glycosylated MUC5AC specific to GI tumors. Its mechanism of action is through ADCC. An IHC based companion diagnostic assay is utilized to select pts whose tumors express the target (approx. 65-70%). A prior study administering N to pts with advanced PC refractory to chemotherapy was well tolerated with disease stabilization and prolongation of OS. Furthermore 2 of 5 pts receiving the combination of G+N following progression on F remain alive at 10 and 12 months respectively. Methods: The primary objective of this phase 2.5 study is to determine if the combination of N and G plus A can improve the OS for pts who have PC over G plus A alone in the post F setting. The trial is a 2-arm randomized 1:1 multi-institution trial of N plus G and A vs. G and A. Eligible pts would be expected to have an estimated 4.5 to 4.8 month median OS with G alone, but this may be enhanced somewhat with the addition of A. The goal is to determine if the use of N along with G and A will result in pts having an increased median OS of 8 months vs. an estimated 5 months without N. Kaplan-Meier curves and a two-tailed log-rank test will be the primary analysis methods. All pts must have tissue positive for the MUC5AC variant (≥20% by IHC). Because N has been established to be safe when given with G alone but not with the combination of G and A, stopping rules for safety will be adhered to for the first 6 pts randomized to G/A plus N. Enrollment to the study has commenced. Correlative studies will utilize both PBMCs and serum for immune monitoring. Frequency, phenotype and function of different immune cells (including CD8+ T cells, CD4+ T cells, Tregs and MDSCs) will be analyzed. Clinical trial information: NCT01834235.