gebhart/patrepeval huggingface dataset:
Novel transcription from the Epstein-Barr virus terminal EcoRI fragment, DIJhet, in a nasopharyngeal carcinoma (1990)

Transcription of Epstein-Barr virus (EBV) genes in epithelial tissue, one of the two principal cell types infected by EBV, is not well characterized. EBV transcription in a nasopharyngeal carcinoma established in nude mice, C15, has been analyzed by using strand-specific RNA probes and sequence analysis of a C15 cDNA library. In C15, two equally abundant mRNAs of 3.7 and 2.8 kilobases (kb) are encoded by the sequences that encode latent membrane protein (LMP). Hybridization with probes specific for the 3' end of the LMP mRNA to Northern (RNA) blots and sequence analysis of cDNAs representing the messages indicated that the 3.7- and 2.8-kb mRNAs are 3' coterminal. Sequence analysis of additional cDNAs revealed an mRNA that is spliced identically to the LMP mRNA but is initiated 5' to the promoter for LMP. A probe representing the sequences contained within the cDNA which are 5' to the LMP promoter identified the 3.7-kb mRNA in C15 and a low-abundance 3.7-kb mRNA in B95-8 RNA. These data indicate that transcription of the LMP-encoding sequences is complex and that LMP can be expressed from an additional RNA in both nasopharyngeal carcinoma and lymphoid cells. Hybridization with BamHI-A identified a predominant 4.8-kb mRNA and two less abundant larger-molecular-weight mRNAs transcribed in C15. These mRNAs are consistently expressed in all passages in nude mice of the C15 tumor. Hybridization with strand-specific probes and sequence analysis of three cDNAs revealed that these mRNAs are transcribed from left to right. Sequence analysis of cDNAs representing the 3' end of the mRNAs identified an open reading frame that could potentially encode a protein of 174 amino acids. In situ hybridization of a 35S-labeled RNA probe homologous to the BamHI-A cDNA to tissue sections revealed that the BamHI-A mRNA is not focally expressed and is transcribed in all cells within the C15 tumor. Linear forms of EBV DNA were not detected in any of the C15 tumors, and replicative viral antigens have not been detected. These data suggest that the C15 tumor represents a latently infected tumor and that the transcription from BamHI-A, which is expressed in all cells, is not associated with virus replication.
Effect of Luminal Somatostatin on Acid Secretion and Gastrin Release (1980)

The mechanisms by which somatostatin inhibits acid secretion when infused into the lumen of the stomach have been examined in 20 healthy subjects. The acid secretory response to distension with 500 ml of neutral water was examined in nine successive 10-min test periods in each subject. Samples of serum and boiled neutral gastric juice were collected and frozen for later immunoassay for gastrin. Somatostatin was added to the distending fluid in a concentration of 600 pg/ml in the middle 3 test periods in 10 test subjects, and placebo added in the same 3 test periods in 10 control subjects. The addition of somatostatin inhibited the rate of acid secretion as compared with placebo alone in the control subjects (p < 0.025) without altering the concentration of immunoreactive gastrin in the serum but reducing the concentration of immunoreactive gastrin in gastric juice (p < 0.02). The data are consistent with the suggestions that the intraluminal administration of somatostatin inhibits antral gastrin release in a paracrinic manner and inhibits acid secretion indirectly by inhibiting lumina gastrin-mediated acid secretory activity.
Localization of ammonia-metabolizing enzymes in human liver: Ontogenesis of heterogeneity (1989)

Immunohistochemical analysis of human liver (8 to 94 years) shows a compartmentation of ammonia-metabolizing enzymes across the acinus. The highest concentration of carbamoylphosphate synthetase (ammonia) is found in the parenchymal cells around the terminal portal venules. Glutamine synthetase is found in a small pericentral compartment two to three cells thick. In contrast to observations in rat liver, in human liver a well-recognizable intermediate zone can be distinguished in which neither enzyme can be detected. This intermediate zone is not yet established at the age of 8 years but can be recognized in livers from 25 years onward. Carbamoylphosphate synthetase can already be detected in the liver of human fetuses at 5 weeks of development. The enzyme distribution reveals a random heterogeneity among the hepatocytes, suggesting that not all hepatocytes start to accumulate carbamoylphosphate synthetase at the same time. From 9 weeks of development onward, the enzyme becomes homogeneously distributed throughout the liver parenchyma until at least 2 days after birth. Glutamine synthetase cannot be detected during this period. In addition, the definitive architecture of the acinus is not yet completed at birth. These results therefore support the idea that in human liver, metabolic zonation with respect to NH3 metabolism exists as it does in rat liver. Furthermore, the data show that this functional compartmentation becomes established concomitant with the development of the acinar architecture.(ABSTRACT TRUNCATED AT 250 WORDS)
Inhibitory effect of topical application of a green tea polyphenol fraction on tumor initiation and promotion in mouse skin (1992)

A green tea polyphenol fraction was evaluated for its ability to inhibit tumor initiation by polycyclic aromatic hydrocarbons and tumor promotion by a phorbol ester in the skin of CD-1 mice. Topical application of the green tea polyphenol fraction inhibited benzo[a]pyrene- and 7,12-dimethylbenz[a]-anthracene-induced tumor initiation as well as 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced tumor promotion. Topical application of the green tea polyphenol fraction also inhibited TPA-induced inflammation, ornithine decarboxylase activity, hyperplasia and hydrogen peroxide formation. Studies with individual polyphenolic compounds in green tea indicated that topical application of (-)-epigallocatechin gallate, (-)-epigallocatechin and (-)-epicatechin gallate inhibited TPA-induced inflammation in mouse epidermis.
International cooperation in healthcare: model of IRCCS Policlinico San Donato and Bambini Cardiopatici nel Mondo Association for congenital heart diseases (2016)

Cooperation activity in training programmes promoted by IRCCS Policlinico San Donato and Bambini Cardiopatici nel Mondo Association is a model of cooperation between people as an alternative intervention in promoting the right to healthcare, especially offering programmes of training and medical care on cardiovascular and congenital heart disease. This new strategy, implemented in several developing countries, has absolutely contributed to the improvement of the medical services concerning the diagnostic and surgical approach in the treatment of paediatric and adult cardiovascular disease. To strengthen this kind of activity, both IRCCS Policlinico San Donato and Bambini Cardiopatici nel Mondo have introduced a global perspective aiming at the realization of surgical missions 'in situ', building new cardiac surgery units in collaboration with the local partners, which are mainly university hospitals. They, furthermore, support financially the scholarship and accommodation in favour of medical and paramedical staff.
Inhibition of Rat Renal Fibroblast Proliferation by Halofuginone (2006)

Halofuginone exhibits antifibrotic effects in rat renal papillary fibroblasts in culture, in terms of inhibition of proliferation and inhibition of MMP-2. These findings could have therapeutic potential.
Conformational analyses and molecular-shape comparisons of a series of indanone-benzylpiperidine inhibitors of acetylcholinesterase (1992)

Conformational analyses and molecular-shape comparisons were carried out on an analogue series of indanone-benzylpiperidine inhibitors of acetylcholinesterase (AChE). It was possible to define an active conformation with respect to the flexible geometry of the benzylpiperidine moiety, as well as an active conformation of the indanone ring-piperidine ring substructure for analogues having a single spacer group between these rings. No active conformation could be postulated for analogues having two or three spacer units between the indanone and piperidine conformation could be postulated for analogues having two or three spacer units between the indanone and piperidine rings. Still, a receptor binding model can be constructed for all indanone and piperidine ring substructures. The postulated active conformation for 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride (1a), a potent AChE inhibitor, is close to the crystal structures of 1a with respect to the indanone-piperidine substructure, but differs from the crystal structures for the benzylpiperidine moiety. However, the crystal conformations and the postulated active conformation of the benzylpiperidine portion of the AChE inhibitor are estimated to be about equally stable. A trans-decalin analogue of 1a can adopt the postulated active conformation as shown by calculation and as seen in its crystal structure. The inactivity of this analogue is explained by the added steric size of the decalin unit and/or the time-average valence geometry behavior at the spiro junction to the indanone ring.
Effect of amino acid substitution in amphiphilic α-helical peptides on peptide-phospholipid membrane interaction (1999)

It was previously found that a cationic amphiphilic peptide, Ac-(Leu-Ala-Arg-Leu)3-NHCH3 (4(3)), caused the destabilization of a phospholipid membrane and showed strong antibacterial activity [Lee et al. Biochim. Biophys. Acta 1986; 862: 211-219]. In order to investigate the effect of changing alpha-helix propensity, hydrophobicity and basicity in 4(3) on the peptide conformation and activity, the 4(3) analogs, [Gly (or Val)6]4(3), [Gly (or Val)2,6]4(3), [Gly (or Val)2,6,10]4(3), [Gln3]4(3), [Gln3,7]4(3) and [Gln3,7,11]4(3) were synthesized. Except for [Val2,6]4(3) and [Val2,6,10]4(3), which mainly formed a beta-structure, other peptides formed an alpha-helix and showed moderate membrane-perturbing activity toward neutral and acidic lipid vesicles. All the peptides other than [Val2,6,10]4(3) and [Gln3,7,10]4(3) had the antibacterial activity comparable with that of 4(3). The relationship between the membrane-perturbing activity and the antibacterial activity was not always parallel. Conclusively, the Ala-->Val substitution in 4(3) causes the change of peptide conformation and the presence of a cationic amino acid residue is necessary for the antibacterial activity.
Statins Ameliorate Endothelial Barrier Permeability Changes in the Cerebral Tissue of Streptozotocin-Induced Diabetic Rats (2005)

Statins may have favorable effects on endothelial barrier function. The effect of rosuvastatin and simvastatin therapy (10 mg/kg) for 5 weeks on blood-brain barrier (BBB), blood-retinal barrier (BRB), and cardiac muscle permeability of streptozotocin-induced diabetic rats was studied. The size-selective permeability of different vascular beds to a group of fluorescein isothiocyanate dextrans of varying molecular weights was measured. The volume of distribution of 250-, 70-, and 40-kDa dextrans in the cerebral tissue of diabetic rats were significantly increased. The volume of distribution of these dextrans in cerebral tissue was normalized by both statins. Diabetes did not significantly alter the BRB, but both statins decreased the volume of distribution of 70- and 40-kDa dextrans in the retina. The volume of distribution of 40 kDa in cardiac muscle was increased in diabetes, and this change was prevented with statin treatment. Treatment with rosuvastatin and mevalonate (150 mg/kg in drinking water for 5 weeks) did not alter the volume of distribution measurements. We concluded that 1) diabetes in rats is associated with significant changes in the BBB permeability; 2) statin treatment improves the endothelial barrier function in cerebral tissue, retina, and cardiac muscle; and 3) this statin effect could not be attributed to HMGCoA reductase inhibition.
PKCS #12: Personal Information Exchange Syntax v1.1 (2014)

PKCS #12 v1.1 describes a transfer syntax for personal identity
information, including private keys, certificates, miscellaneous
secrets, and extensions. Machines, applications, browsers, Internet
kiosks, and so on, that support this standard will allow a user to
import, export, and exercise a single set of personal identity
information. This standard supports direct transfer of personal
information under several privacy and integrity modes. This document
represents a republication of PKCS #12 v1.1 from RSA Laboratories'
Public Key Cryptography Standard (PKCS) series. By publishing this
RFC, change control is transferred to the IETF.
Evaluation of lufenuron as a chemosterilant against fruit flies of the genus Anastrepha (Diptera: Tephritidae) (2010)

Although further investigations are required, the present results demonstrate that the use of lufenuron for controlling A. striata could be potentially viable.
Direct temporal-resolution calibration of new-generation dissector (2016)

Recently a new generation of picosecond dissectors were created on the basis of the PIF-01/S1 picosecond streak-image tube designed and manufactured at the GPI Photoelectronics Department. The results of the measurements of instrument characteristics of the new dissector, which were carried out in the static mode, showed that temporal resolution of the dissector can be better than 3-4 ps (FWHM). The results of temporal resolution calibration of the new-generation picosecond dissector carried out at the specialized set-up based on a femtosecond Ti:sapphire laser are given in this work.
The Nuclear Fuel Cycle Around the World [Slides] (2014)

Abstract Not Provided.
Dual‐mode equalization for digital mobile radio (1991)

Abstract The performance of digital mobile radio systems when transmitting at over several tens of kbit/s severely degrades with the onset of fast fading multipath propagation. This paper proposes a dual‐mode equalization (DME) method to overcome the degradation and experimentally verifies the effectiveness of the method. The new method uses decision feedback equalizers (DFEs) in two modes simultaneously, a normal mode, and a time‐reversal mode, and selects the best equalization result. The time‐reversal equalization mode improves the characteristics of equalization and adaptation in the non‐minimum phase condition. It converts the nonminimum phase to the minimum phase condition by the time‐reversal operation. Principles of dual‐mode equalization, an algorithm for mode output selection, and timing problems are discussed in detail. Experiments demonstrate average BER performance in two‐path and typical multipath environments. The proposed dual‐mode equalization technique improves average BER performance by 2 dB E b /N 0 .
Validation of the endopep-MS method for qualitative detection of active botulinum neurotoxins in human or chicken serum (2014)

Validation of the endopep-MS method for qualitative detection of active botulinum neurotoxins in human or chicken serum
Calibrations of a high-suction tensiometer (2008)

High-suction tensiometers are able to measure suctions up to 2 MPa. Direct calibration at such high suctions requires the imposition of negative water pressures, which are difficult to achieve using facilities commonly available in soil mechanics laboratories. For this reason, tensiometers are usually calibrated in the positive pressure range, and such calibration is subsequently extrapolated to negative pressures. This paper examines different experimental techniques to assess the accuracy of such extrapolation. Any error in the calibration process would be directly reflected in the measured values of suction, and might be particularly significant (in relative terms) for the measurement of low suctions. In addition, the results of this study show that calibration in the positive range is affected both by the physical configuration of the tensiometer during calibration and by aspects of its design. The paper concludes that linear extrapolation of the calibration from the positive to the negative range is sufficiently accurate provided that calibration is done under conditions that closely match the conditions in which the tensiometer will be used. Owing to structural differences between tensiometers, and also to suction-induced ‘calibration hysteresis', at least one check on the accuracy of the extrapolated calibration equation over a range of negative pressure should be performed, even if at low values of suction.
Cold regions engineering, putting research into practice : proceedings of the tenth international conference, August 16-19, 1999, Lincoln, New Hampshire (1999)

This proceedings of the Tenth International Conference on Cold Regions Engineering held in Lincoln, New Hampshire, on August 16-19, 1999, presents a state-of-the-art look at cold regions engineering research and its application to real-world problems. Over 80 technical papers covering a broad range of topics include: modernization and upgrade of facilities at the U.S. Amundsen-Scott South Pole Station; design and construction problems in frozen ground and perma-frost; water and wastewater systems, bioremediation, and contaminant analysis in cold regions; use of satellite and airborne imagery for detection of oil spills and environmental degradation; solutions to problems affecting pavements, railroads, airfields, and snow-covered roads; snowmelt, runoff, ice control, and modeling of ice-covered rivers; structural and foundation problems; tree and power line damage due to freezing rain and ice storms; and sea ice forces on structures and the effects of ice on riprap. These papers represent cold regions engineering research and practice in Canada, China, Finland, Japan, Norway, Russia, Sweden, the United Kingdom, and the United States.
Physical and Chemical Characteristics of Apples in European Markets (1994)

Comparisons were made of the major physical and chemical characteristics of seven cultivars of apples ( Malus domestica Borkh.) produced and imported into Western Europe from 13 origins. During the 1990-91 marketing season, `Delicious', `Golden Delicious', `Granny Smith', `Elstar', `Jonagold', `Gala', and `Fuji' apples were included in the study. Physical characteristics evaluated were length-to-diameter ratio, shape, external defects, internal defects, water core, bruises, firmness, blush surface, and color. Chemical characteristics evaluated were starch, juice content, soluble solids, acids, and ascorbic acid. Significant differences in some of these quality characteristics were found between the different origins. Apples produced in the United States, particularly `Delicious', had some superior quality characteristics compared to fruit from other origins.
Domain studies in single-crystal ferrite MIG heads with image-enhanced, wide-field, Kerr microscopy (1992)

The magnetic domain structure at the media-facing surfaces of the single-crystal ferrite MIG heads is investigated using the magnetooptical Kerr effect. Domain behavior depends strongly on the stress state and surface treatment of the head. The pole tips display coercive zig-zag domain walls, which are nucleated at the gap by write current pulses. For the samples studied, nucleation and motion of these walls are different between heads which exhibit small secondary pulses in the read-back signal and heads which do not.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Influence of magnetoelastic effect and domain structure on pole erasure occurrence in perpendicular recording heads (2006)

The influences of the magnetoelastic effect on the occurrence of pole erasure were investigated. It was found that the occurrence of pole erasure was related to the anisotropy energy induced by the magnetoelastic effect in the pole tip. The anisotropy energy by the magnetoelastic effect was dominated by the external stress on the pole tip and the magnetostriction of the pole film. The magnetization state in the yoke also influenced the occurrence of pole erasure. It was found that the yoke with large anisotropy energy in direction to the head height and the complex domain structure in the yoke made pole erasure worse.
El desarrollo de la acción penal privada en la legislación procesal penal mexicana (2011)

La reforma a la Constitucion federal mexicana de junio de 2008, estatuyo, entre otras cosas, que a la par de la accion penal publica en la persecucion del delito, la ley estableceria los supuestos excepcionales en que tambien procederia la accion penal privada.

Abstract: The reform of the Mexican federal Constitution of June 2008, statues, among other things, that the pair of public prosecutions in criminal trials, the law set out the exceptional circumstances in which criminal action would come too private.
Comparison of integrated samplers for mass and composition during the 1999 Atlanta Supersites project (2003)

The first of the U.S. Environmental Protection Agency's (EPA) Particulate Matter (PM) Supersites projects was established in Atlanta, GA, during the summer of 1999 in conjunction with the Southern Oxidants Study. The short‐term primary focus was a one month intensive field campaign to evaluate advanced PM measurement methods for measuring PM mass and the chemical and physical properties of PM. Long‐term objectives are being met through coordination and cooperation with existing programs in Atlanta and the southeastern United States. Three categories of PM instruments were deployed during August 1999: time‐integrated or discrete filter‐based methods like those used in EPA's PM2.5 Chemical Speciation Network; continuous or semicontinuous species specific methods, most of which are still in development; and single particle mass spectrometers, the most advanced methods looking at the chemical composition of single particles. The focus of this paper is on comparison of the discrete filter‐based methods. Samples were collected by 12 discrete filter‐based samplers on an every other day basis during the study period at the Jefferson Street Southeastern Aerosol Research and Characterization (SEARCH) study site. Samples were analyzed for PM2.5 mass, sulfate, nitrate, ammonium, organic carbon, elemental carbon, and trace elements, the latter by XRF. Samplers used a variety of filters; denuder‐filter combinations in the case of nitrate and organic carbon, particle size fractionating devices, and flow rates. Ambient concentrations for most species were sufficiently above detection limits for testing comparability among samplers, with nitrate being the most notable exception for the major components having an average reported value of 0.5 μg/m 3 . Several trace species, e.g., As and Pb, also were often below limits of detection of the analysis method. Results indicate that real differences exist among the samplers tested for most species, with sulfate and ammonium being the exceptions, under the conditions tested. Differences are due to sampler design, and in the case of elemental carbon, also due to the use of different chemical analysis methods. Comparability among most of the samplers for a given species was: mass (±20%); sulfate (±10%); nitrate (±30–35%); ammonium (±10–15%); organic carbon either with or without denuders (±20%) or including samplers both with and without denuders (±35–45%); elemental carbon (±20 to ±200%, the latter if different analysis methods are used); and minor and trace elements (±20–30%). A net organic carbon‐sampling artifact on quartz‐fiber filters was estimated from the comparison of denuded versus undenuded samples and is in the range of 1–4 μg/m 3 .