gebhart/patrepeval huggingface dataset:
Broadband Robust Controller Design of Multi-Frequency-Band Parallel Control System (2007)

This paper proposes an approach on broadband robust controller design of multi-frequency-band parallel control system in order to achieve a significant vibration reduction in broadband frequency range. Mechanical systems usually have vibration and noise problems in various frequency ranges. A complex high-order modeling has to be conducted to control the vibration and noise in broadband frequency range. In this case, the modeling error is generally increased, resulting in a degradation of control performance. This study designs the multiple subcontrollers based on the multiple sub-models derived in the corresponding frequency ranges. The order of each sub-model becomes small and so the modeling accuracy is improved. The total controller is constructed as the parallel circuit with each sub-controller designed in each frequency range. Each sub-controller is designed to satisfy the closed-loop stability against the interference to other sub-controllers in thisstudy. It is verified that the calculation efficiency and control performance can be enhanced by the proposed control strategy.
PI auto-tuning and performance assessment in HVAC systems (2013)

Proportional-integral control with default tuning numbers is often used in Heating Ventilation and Air Conditioning (HVAC) systems resulting in suboptimal control performance. A well-known relay based auto-tuning method is modified for a class of HVAC systems and a novel, corresponding performance criteria developed for evaluating resulting control performance. The developed methodology, including modified auto-tuning method and performance criteria assessment, has been successfully demonstrated in a field trial for a Fan Coil Unit (FCU) in an HVAC system.
Microbunching Instability as a Caustic Phenomenon (2017)

Microbunching instability if left alone, threatens to degrade the beam quality of high brightness electron beams in Free Electron Lasers. Recently, caustic formation in electron trajectories was identified as a mechanism describing current modulations in accelerated particle beams. Here we consider CSR-induced microbunching as a caustic phenomenon. This analysis reports on the influence of longitudinal dispersion, R56, on the microbunching process, as well as elucidating the influence of the second and third order longitudinal dispersion values, T566 and U5666.
The scientific basis for the immunotherapy of human malignant mesothelioma (1993)

The development of immunotherapeutic protocols for the treatment of malignant mesothelioma, a tumour that is resistant to conventional forms of therapy, requires the development of a sound scientific understanding of the relationship between malignant mesothelioma cells and the immune system. Initially we developed a panel of five human mesothelioma cell lines which have been fully characterized, for in vitro and heterotransplant studies. Using these cell lines we have demonstrated that mesothelioma cells are resistant to natural killer (NK) lysis but susceptible to lymphokine-activated killer (LAK) lysis. In addition, we have demonstrated in vitro sensitivity to a number of cytokines, including tumour necrosis factor and the interferons. All human mesothelioma cell lines express immune recognition molecules of the human leucocyte antigen (HLA) class I family and in some cell lines class II molecules can be induced. We then developed an animal model to further evaluate these processes in vivo. Following intraperitoneal asbestos injection, five CBA and five Balb/C passageable mesothelioma cell lines have been produced and characterized, and these cells have similar growth factor and major histocompatibility complex (MHC) protein expression patterns to human mesothelioma cell lines. Animals with malignant mesothelioma demonstrate growth inhibition following therapy with interferon-α (INF-α) or interleukin-2 (IL-2) plus LAK cells. Clinical trials of immunotherapy in humans have commenced. Whereas therapy with intrapleural IL-2 plus LAK cells was associated with severe local and systemic side-effects and was therefore stopped, therapy with recombinant human interferon-alpha-2a (Roferon A) produced partial (&gt;50%) reduction in tumour bulk in three out of 25 patients and a delayed complete response in another patient. Current trials utilize recombinant human interferon-alpha-2a plus adriamycin. We conclude that there is a solid scientific foundation for the establishment of investigative immunotherapeutic protocols for patients with malignant mesothelioma.
p53 status is neither a predictive nor a prognostic variable in patients with advanced ovarian cancer treated with a paclitaxel-based regimen. (2001)

p53 status seems to be neither a predictive nor a prognostic variable in patients with advanced ovarian cancer treated with a paclitaxel-based regimen. These results are consistent with experimental data showing that paclitaxel cytotoxicity in ovarian cancer is likely to be mediated by a p53-independent pathway.
Influence of muscle fiber type and pedal frequency on oxygen uptake kinetics of heavy exercise (1996)

We tested the hypothesis that the amplitude of the additional slow component of O2 uptake (VO2) during heavy exercise is correlated with the percentage of type II (fast-twitch) fibers in the contracting muscles. Ten subjects performed transitions to a work rate calculated to require a VO2 equal to 50% between the estimated lactate (Lac) threshold and maximal VO2 (50% delta). Nine subjects consented to a muscle biopsy of the vastus lateralis. To enhance the influence of differences in fiber type among subjects, transitions were made while subjects were pedaling at 45, 60, 75, and 90 rpm in different trials. Baseline VO2 was designed to be similar at the different pedal rates by adjusting baseline work rate while the absolute increase in work rate above the baseline was the same. The VO2 response after the onset of exercise was described by a three-exponential model. The relative magnitude of the slow component at the end of 8-min exercise was significantly negatively correlated with % type I fibers at every pedal rate (r = 0.64 to 0.83, P < 0.05-0.01). Furthermore, the gain of the fast component for VO2 (as ml.min-1.W-1) was positively correlated with the % type I fibers across pedal rates (r = 0.69-0.83). Increase in pedal rate was associated with decreased relative stress of the exercise but did not affect the relationships between % fiber type and VO2 parameters. The relative contribution of the slow component was also significantly negatively correlated with maximal VO2 (r = -0.65), whereas the gain for the fast component was positively associated (r = 0.68-0.71 across rpm). The amplitude of the slow component was significantly correlated with net end-exercise Lac at all four pedal rates (r = 0.64-0.84), but Lac was not correlated with % type I (P > 0.05). We conclude that fiber type distribution significantly affects both the fast and slow components of VO2 during heavy exercise and that fiber type and fitness may have both codependent and independent influences on the metabolic and gas-exchange responses to heavy exercise.
Beamforming in Single Frequency Networks with Connection Control (2009)

We evaluate the benefit of beamforming for broadcast/multicast transmission using single frequency networks (SFNs), where the beamforming weights are jointly optimized for the base stations participating in the SFN transmission. The aim is to reduce the total transmission power under the constraint of the provision of a certain mean SNR to all users. In order to keep the number of base stations to which a user is connected low, we apply a sensitivity analysis to the optimization problem and identify the users that should connect to further base stations to lower the required transmission power most effectively.
Bioderived materials for stimuli-responsive, adaptive, and neuromorphic systems: A perspective (2022)

In this concept article, we review recent works on the use of biologically-derived materials, including biomolecules, hybrid biomolecular composites, and natural tissues for achieving stimuli-responsiveness, adaptability, and memory storage for potential neuromorphic computing applications. Unlike solid-state materials, bioderived platforms are often intrinsically modular, including possessing the ability to leverage the diversity of naturally multifunctional biomolecules, cornerstones in biological transduction, signaling, and learning. The primary neuromorphic functionality of bioderived systems considered here is memory resistance, as obtained through combinations of resistive switching, activity-dependent plasticity, and memory storage. In some cases, these capabilities are achieved in bio-derived systems by closely emulating the structure, function, or signaling mechanisms found in living neurons. Our review considers bioderived systems that span multiple length scales and levels of hierarchical complexity: from single-molecule enabled devices to intact tissues, interrogated either in vitro or in vivo on living organisms. Through this exercise, we offer our perspective on research opportunities in the development and use of synapse- and neuron-inspired bioderived systems, including the prospect of biocompatible, and even tissue-like, neuromorphic materials to smartly monitor and treat injury and disease, deliver therapeutics, and interpret neural activity. These capabilities could unlock a new generation of smart, adaptable bioderived composites that autonomously report, learn (i.e., classify, forecast), compute, and actuate in the direct vicinity of living cells and tissues, i.e. at the edge of biology.
Buffering in query evaluation over XML streams (2005)

All known algorithms for evaluating advanced XPath queries (e.g., ones with predicates or with closure axes) on XML streams employ buffers to temporarily store fragments of the document stream. In many cases, these buffers grow very large and constitute a major memory bottleneck. In this paper, we identify two broad classes of evaluation problems that independently necessitate the use of large memory buffers in evaluation of queries over XML streams: (1) full-fledged evaluation (as opposed to just filtering) of queries with predicates; (2) evaluation (whether full-fledged or filtering) of queries with "multi-variate" predicates.We prove quantitative lower bounds on the amount of memory required in each of these scenarios. The bounds are stated in terms of novel document properties that we define. We show that these scenarios, in combination with query evaluation over recursive documents, cover the cases in which large buffers are required. Finally, we present algorithms that match the lower bounds for an important fragment of XPath.
Safety evaluation of the food enzyme chymosin from the genetically modified Aspergillus niger strain DSM32805 (2022)

The food enzyme chymosin (EC 3.4.23.4) is produced with the genetically modified <i>Aspergillus niger</i> strain by Chr. Hansen. The genetic modifications do not give rise to safety concerns. The food enzyme is free from viable cells of the production organism and its DNA. It is intended to be used in milk processing for cheese production and for the production of fermented milk products. Dietary exposure was estimated to be up to 0.09 mg total organic solids (TOS)/kg body weight (bw) per day in European populations. Genotoxicity tests did not raise a safety concern. The systemic toxicity was assessed by means of a repeated dose 90-day oral toxicity study in rats. The Panel identified a no observed adverse effect level at the highest dose of 1,000 mg TOS/kg bw per day the highest dose tested, which when compared with the estimated dietary exposure, results in a margin of exposure of at least 10,600. Similarity of the amino acid sequence of the food enzyme to those of known allergens was searched and two matches with respiratory allergens were found. The Panel considered that, under the intended conditions of use, the risk of allergic sensitisation and elicitation reactions by dietary exposure cannot be excluded, but the likelihood for this to occur is considered low. Based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use.
Marine Natural Products as Phospholipase A<sup>2</sup> Inhibitors (1997)

He developed training in nutritional chemistry based on the academic degree, and thus Finland was the first country in Europe which included nutrition in its academic curricula. He was also the pioneer of modern nutritional
Discovery of an Orally-Active Nonsteroidal Androgen Receptor Pure Antagonist and the Structure-Activity Relationships of Its Derivatives (2008)

The 3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethylthiohydantoin derivatives which have carboxy-terminal side chains were synthesized and their agonistic/antagonistic activities against androgen receptor (AR) measured. Among them, compound 13b showed antagonistic activity (IC50=130 nM) with no agonistic activity even at 10000 nM. This compound exhibited significant metabolic stability and oral antiandrogenic activity (ED50=7 mg/kg).
Locally Invasive Aspergillosis Within an Intralobar Sequestration in a Child (2008)

The rare association of aspergillosis and bronchopulmonary sequestration has been reported in 21 patients. We present a case of locally invasive aspergillosis complicating an intralobar sequestration in a 10-year-old girl with asymptomatic peripheral eosinophilia. This is the youngest such patient reported to date.
Fiberglass Encasement Method for Undisturbed Soil Cores (1993)

An improved method for collecting intact cylindrical soil cores is presented. A soil cylinder was carved in a soil pit using a steel chimney flange to aid in the formation of a straight and uniform core. The cylinder sides were encased in fiberglass-reinforced polyester resin. The ends of the soil core were coated with liquid rubber latex. The latex can be easily removed later with minimal soil disturbance. The technique was used to prepare soil cores of 15-cm diam. And up to 1 m in length. The encasement material is lightweight, strong, and waterproof. Fittings for flow-measuring equipment can be easily attached to the resulting core. Soil cylinders encased by this method are well suited for saturated and unsaturated laboratory investigations.
A Concise Guide to Complex Hadamard Matrices (2006)

Complex Hadamard matrices, consisting of unimodular entries with arbitrary phases, play an important role in the theory of quantum information. We review basic properties of complex Hadamard matrices and present a catalogue of inequivalent cases known for the dimensions N = 2,…,16. In particular, we explicitly write down some families of complex Hadamard matrices for N = 12, 14 and 16, which we could not find in the existing literature.
Food Browning and Its Prevention:  An Overview (1996)

Enzymatic and nonenzymatic browning reactions of amino acids and proteins with carbohydrates, oxidized lipids, and oxidized phenols cause deterioration of food during storage and processing. The loss in nutritional quality and potentially in safety is attributed to destruction of essential amino acids, decrease in digestibility, inhibition of proteolytic and glycolytic enzymes, interaction with metal ions, and formation of antinutritional and toxic compounds. Studies in this area include influence of damage to essential amino acids on nutrition and food safety, nutritional damage as a function of processing conditions, and simultaneous formation of deleterious and beneficial compounds. These compounds include kidney-damaging Maillard reaction products, mutagens, carcinogens, antimutagens, antioxidants, antibiotics, and antiallergens. This overview covers the formation, nutrition, and safety of glycated proteins, characterized browning products, and heterocyclic amines. Possible approaches to inhibiting browning reactions and preventing adverse effects of browning during food processing and food consumption, including protection against adverse effects of heterocyclic amines by N-acetylcysteine, caffeine, chlorophyll, conjugated linoleic acid, lignin, and tea extracts, are also described. This research subject covers a complex relationship of the chemistry, biology, and pathology of browning products and the impact on human nutrition and health. Future study should differentiate antinutritional and toxicological relationships, define individual and combined potencies of browning products, and develop means to prevent the formation and to minimize the adverse manifestations of the most antinutritional and toxic compounds. Such studies should lead to better and safer foods and improved human health. Keywords: Browning prevention; food browning; food safety; glycated proteins; glycosylation; heterocyclic amines; human health; Maillard products; nutrition
Effects of PPARg agonist pioglitazone on rat hepatic fibrosis (2004)

PPARgamma agonist pioglitazone greatly retards the progression of rat hepatic fibrosis induced by CCl(4) through inhibition of HSC activation and amelioration of hepatocyte necroinflammation in rats.
Abstract 12671: Weight Loss Improves Cardiometabolic Health as Measured by Plasma Proteins in Individuals With Type 2 Diabetes (2022)

Introduction: The DiRECT (UK cohort) and DIADEM-1 (Middle Eastern/North Africian cohort) trials in patients with type 2 diabetes demonstrated average weight loss of &gt;10kg spurred by dietary intervention led to 46-61% diabetes remission at 12 months. Here we investigated cardiometabolic outcomes of these cohorts using predictive proteomic SomaSignal ® tests. Methods: Eight cardiometabolic SomaSignal tests (each derived from ~5000 plasma proteins measurements using aptamer-based proteomics assay) related to cardiometabolic health were assessed in baseline and 1-year samples in intervention (DiRECT n=118, DIADEM-1 n=66) and control (DiRECT n=144, DIADEM-1 n=76) participants. Results: Despite differences in baseline characteristics (age, ethnicity, diabetes duration, cardiovascular (CV) risk factors), both intervention groups showed similar improvements in overall cardiometabolic outcomes (Figure). Seven SomaSignal tests in DiRECT and six SomaSignal tests in DIADEM-1 significantly improved in the intervention groups compared to respective control arms. Liver fat, glucose intolerance, body fat percentage, resting metabolic rate, visceral fat, and cardiorespiratory fitness predictions significantly improved in intervention arms of both trials with greater relative improvements seen in individuals that lost &gt;10kg. Additionally, CV risk improved significantly in the DiRECT intervention arm (which had higher baseline CV risk compared to DIADEM-1), as well as in both trials among individuals lost &gt;10kg. Conclusion: Proteomic changes suggest widespread improvement in cardiometabolic traits, including CV risk, across both trials of intentional weight loss in individuals with type 2 diabetes. Notably, greater relative improvements in all traits including CV risk were seen in individuals that lost &gt;10kg. These data suggest large intentional weight loss will improve future CV outcomes.
Notes and news (1982)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
A Mechanically Strong, Highly Stable, Thermoplastic, and Self‐Healable Supramolecular Polymer Hydrogel (2015)

Polymerization of glycinamide-conjugated monomer alone in concentrated aqueous solution enables facile formation of a mechanically strong and a highly stable supramolecular polymer (SP) hydrogel because of the cooperatively hydrogen-bonded crosslinking and strengthening effect from dual amide motifs. This SP hydrogel exhibits thermoplastic processability, injectability, and self-reparability because of the dynamic destruction and reconstruction of hydrogen bonds in response to temperature change.
Atmospheric Corrosion Behavior of Al 6xxx Alloys in Qatar State (2016)

Al 6000 series [Al-Mg-Si-Cu] are widely used in oil field for frames, tanks, pipelines and machinery applications. They showed a relatively high corrosion resistant, thermal and electrical conductivity and low cost. Establishing a materials map (Corrosion Atlas) for different region in Qatar. Al 6063 and Al 6082 are part of this map. Studying the forms of corrosion for the two Al alloys at different sites. Studying the corrosion rate, pit aspect ratio and pit density of the Al alloys after different times of exposure at different atmospheric condition. Many authors have been studied the corrosion behavior of aluminum alloys indoor significantly than the outdoor studies. However, the indoor corrosion studies seem to be markedly ignored numbers of air pollutants practically sulfur and chloride contaminations. In addition, weather exposure designs (outdoor tests) of aluminum and its alloys have been performed in different atmosphere all over the world by many countries. The aim of this article is to investigate the atmospheric corrosion behavior of Aluminum alloy Al-6063 after 6 months of exposure at seven different sites in Qatar which are representing different environments (Desert, industrial, coastal and marine) by visual observation with low power optical analysis for counting the pit depth and pit density for each site. In addition, electrochemical techniques were applied on the collected specimens to show the effect of the formed oxide layer on the corrosion behavior. SEM was used to study the susceptibility of studied alloys to intergrainular corrosion and the influence of sulfur and chloride compounds in intergrainular corrosion. The results were put in comparison with indoor test in 3.5% NaCl + 1%HCl mixture using SEM and Accelerated electrochemical techniques.
Effect of Glucose, Galactose, and Different Nitrogen‐Sources on the Activity of Yeast Glutamate Dehydrogenase (NAD and NADP‐Linked) from Normal Strain and Impaired Respiration Mutant (1970)

The activity of glutamate dehydrogenase from baker's yeast grown in various concentrations of glucose and galactose has been studied. The yeasts were grown under aerobic and anaerobic conditions and harvested after 24 h. Experiments have also been carried out with impaired respiration mutants induced by trypaflavine (“petite mutante”). A comparison of the NAD-and NADP-glutamate dehydrogenase activities of normal and impaired respiration yeasts is reported. The repression of the aminating reaction of the glutamate dehydrogenase by ammonia has also been investigated. 1 When the normal cells are grown in a medium which contains 0.3% sugar the main activity of the aminating reaction is glutamate dehydrogenase NADH-linked. When grown anaerobically (with glucose or galactose) the activity of the NADH-enzyme decreases while that of the glutamate dehydrogenase-NADPH increases. In the cells grown anaerobically and in those with impaired respiration, there is no significant activity of glutamate dehydrogenase-NADH in any case. 2 In impaired respiration cells, the levels of activity are similar to those of normal cells grown anaerobically. 3 With higher concentrations of sugars the glutamate dehydrogenase-NADH is strongly repressed, while there is a simultaneous increase of the glutamate dehydrogenase-NADPH. 4 Ammonia acts as a repressor of the glutamate dehydrogenase activity in normal cells. In “petite mutante” the greatest activity of the glutamate dehydrogenase-NADPH was found in cultures with glutamate and alanine as nitrogen source; in all cases, the presence of ammonia either alone or with another nitrogen source represses activity.