gebhart/patrepeval huggingface dataset:
Changes in Endplate Thickness and Apparent Density After Disc Herniation (2013)

Endplates play a major role in intervertebral disc (IVD) health, but the opposite could also be true with changes in IVD affecting the morphological features of endplates. We here hypothesize that changes in biomechanical environment due to disc herniation will change the thickness and apparent density of the endplates at the index level.
Screen Printing Piezoelectric Devices (1987)

This paper intends to demonstrate the feasibility of thick film piezoelectric layers on ceramic substrates. Advantages of this technology for the realisation and improvement of some devices, such as loudspeakers and couplers (to be applied in a communication bus), are described.
Design, implementation, and automation of a risk management approach for man-at-the-End software protection (2023)

The last years have seen an increase in Man-at-the-End (MATE) attacks against software applications, both in number and severity. However, software protection, which aims at mitigating MATE attacks, is dominated by fuzzy concepts and security-through-obscurity. This paper presents a rationale for adopting and standardizing the protection of software as a risk management process according to the NIST SP800-39 approach. We examine the relevant constructs, models, and methods needed for formalizing and automating the activities in this process in the context of MATE software protection. We highlight the open issues that the research community still has to address. We discuss the benefits that such an approach can bring to all stakeholders. In addition, we present a Proof of Concept (PoC) decision support system that instantiates many of the discussed construct, models, and methods and automates many activities in the risk analysis methodology for the protection of software. Despite being a prototype, the PoC’s validation with industry experts indicated that several aspects of the proposed risk management process can already be formalized and automated with our existing toolbox and that it can actually assist decision making in industrially relevant settings.
Fiber-Coupled High-Speed OH-PLIF Imaging in Turbulent Flames (2012)

A fiber-coupled, ultraviolet, planar laser-induced-fluorescence (UV-PLIF) system operating at 10-kHz repetition rate is developed and demonstrated for probing hydroxyl radicals (OH) in turbulent flames. A 283-nm, nanosecond-duration laser is used to excite the (1,0) band of the OH A-X system, and the subsequent fluorescence from the (0,0) and (1,1) bands are detected. The system is designed to transmit the required excitation pulse energy through a 6-m-long optical fiber to enable OH-PLIF measurements. Single-laser-shot PLIF images at 10 kHz are obtained for visualizing OH distribution in pulsating turbulent flames. It is experimentally demonstrated that by utilizing a long multimode fiber, a non-uniform input-beam profile can be transformed to a desired, nearly Gaussian beam profile for PLIF imaging. The current results show significant promise for extending fiber-coupled highspeed UV-PLIF diagnostics to harsh environments such as those associated with combustors and gas-turbine-engine test facilities.
Compact and high-accuracy RF MEMS capacitive series devices (2005)

MEMS technology is presented as a promising technology to realize high Q variable capacitors and RF switches with high performance and with high levels of integration. These devices are key elements for systems like phase shifters, tunable filters and matching networks. However, the reliability and the yield of the RF MEMS devices remain the key limiting factors holding the MEMS technology from spreading in the industrial applications. From a RF designer's point of view, reliability and yield are closely related to the accuracy of the definition of the up- and down-state capacitances of the devices. In this paper, we propose a novel compact series capacitive structure with improved predictability and RF performance. The new design mimics a clamped-clamped bridge to lower its sensitivity to the process-induced stress gradient in the up-state. The shape of the device and its consequent parameters, e.g. up- and down-capacitances, are thus more accurately defined even in presence of non-ideal clamping conditions. Unlike the series switchable capacitors with transverse restraining bridge, the novel device does not suffer from high frequency parasitic resonances. Finally, the novel device implements the floating top metal. This allows accurately defining the down-state capacitance of the design at will. Boosted series capacitive switches with inline-restrained cantilever beams have been realized and measured. The isolation is better than 20dB until 1GHz without optimization. The insertion loss in the down-state is better than 0.2dB in the range 1-20GHz. It further slowly and continuously decays to reach 0.4dB at 40GHz without any resonances.
Abstract 167: Pre-clinical characterization of a novel series of FGFR2 selective inhibitors with potency against clinically relevant mutations (2022)

Abstract The fibroblast growth factor receptor (FGFR) family of protein tyrosine kinases plays a role in many physiological processes including angiogenesis and wound healing. FGFR mutations, fusions, rearrangements, and amplifications have been linked to the pathogenesis of multiple tumor types. For example, approximately 10-15% of patients with intrahepatic cholangiocarcinoma have FGFR2 fusions, and amplification of FGFR2 is prevalent in gastric cancer and implicated in tumor growth. Approved FGFR inhibitors produce responses in patients that harbor FGFR genetic alterations but show reduced activity against key mutations (e.g., V565, N550, etc.). These pan-FGFR inhibitors also frequently show dose-limiting toxicities including hyperphosphatemia which can be linked to the inhibition of FGFR1. To address these issues, a novel series of FGFR inhibitors that are potent and selective reversible inhibitors of FGFR2 with selectivity over FGFR1 have been identified. This series also maintains activity against clinically relevant mutations in the FGFR2 protein. Inhibition of cellular FGFR phosphorylation was measured using engineered cell lines to demonstrate that the inhibitors target both wild-type FGFR2 and activating FGFR2 mutations while sparing FGFR1. In addition, CDX tumor models showed in vivo target engagement and FGFR isoform selectivity. Herein, the in vitro and in vivo characterization of a representative selective reversible FGFR2 inhibitor is described. Citation Format: John Fischer, Karyn Bouhana, Mark J. Chicarelli, Josh Dahlke, Brad Fell, Jennifer Fulton, Anna Guarnieri, Ravi Jalluri, Amber Johnson, Brent Mclean, Max Mejia, Rob Rieger, John Robinson, Mareli Rodriguez, Francis Sullivan, Yang Wang, Shannon Winski, Yeyun Zhou. Pre-clinical characterization of a novel series of FGFR2 selective inhibitors with potency against clinically relevant mutations [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 167.
A Round Table Discussion on Forensic Science in Australia (2011)

Abstract This manuscript is an edited transcript of a round table discussion held during the Australian New Zealand Forensic Science Society International Symposium held in Sydney in 2010. The discussants covered a variety of topics, including the management of science, the handling of quality issues, and the report on forensic science from the U.S. National Academies of Science National Research Council. This discussion offers a frank account of the current state of Australian forensic service providers. These views are then considered in the context of recent events unfolding in the United Kingdom and in a broader international context. It poses the question, are there lessons to be learned from the Australian experience that would have relevance to other parts of the world?
Abstract 11602: Impact of Pre-Operative Type-B Natriuretic Peptide Level on Survival After Aortic Valve Replacement for Aortic Stenosis (2014)

Introduction: Levels of type-B natriuretic peptide (BNP) adjusted for age and sex are a powerful predictor of mortality after the diagnosis of aortic stenosis (AS). Objective: To assess whether BNP activation (compared to normal values) affects mortality after aortic valve replacement (AVR). Methods: In 494 patients with AS, plasma level of BNP was measured pre-operatively at the time of Doppler-Echocardiography. BNP was normalized as BNPratio (BNP measured/BNP maximum normal value for age and sex) to evaluate the impact of BNP activation on post-operative outcomes. Results: Mean age was73±11 years and 300 (61%) patients were male. Mean aortic valve area was 0.82±0.20cm2, mean gradient 51±16mmHg, and mean Left Ventricular Ejection Fraction 59±15%. Incidence of hypertension was 65%, diabetes 27% and chronic kidney disease 22%. Median of BNP was 211 (interquartile: 87-508) and BNPratio 2.2 (1.0-5.2). After adjustment age, gender, body surface area, Charlson score index, presence of symptoms, creatinine, hemoglobin, systolic blood pressure, indexed aortic valve area and left ventricular ejection fraction, the BNPratio (log transformed) was a predictor of long-term mortality (p&lt;0.0001) with an hazard ratio 1.34 (1.14-1.60). Moreover, stratification by BNPratio showed increasing long-term post-operative mortality with BNPratios&gt;2 (Figure). Conclusions: BNP activation defined using BNPratios (normalized for age and sex) is a powerful independent predictor of long-term mortality after aortic valve replacement for AS. Furthermore, patients with a BNPratio&gt;2 before aortic valve replacement incur excess mortality during follow-up in relation to the increasing BNPratio. These data support the use of the BNPratio to guide the timing of AVR.
Behavior at Under-film Corrosion Tips of Zn-Fe Alloy Coated Steel Sheets (1990)

Under-film corrosion behavior of Zn-Fe alloy coating in the tip of corrosion was investigated using the atmospheric exposure test. The better correlation between chlorine penetration distance and paint exfoliation width from scribe was recognized. The formation of deteriorating coating layer due to chlorine ions attacking of coating is an important factor controlling the paint adhesion of zinc alloy coated steel sheets.The durability of coating against chlorine penetration was affected by the coating weight and total zinc weight in the coating. Zn-Fe (10 20% ) alloy coating had better durability against chlorine ion attacking than pure Zn coating because of the difference of coating itself corrosion behavior between these coatings. The effect of Zinc phosphate film was not mainly the controlling factor of durability against chlorine penetration.
Supplementary Figure S1 from Immunomodulatory Activity of a Colony-stimulating Factor-1 Receptor Inhibitor in Patients with Advanced Refractory Breast or Prostate Cancer: A Phase I Study (2023)

&lt;p&gt;Change in tumor biomarkers by response (RECIST) during LY3022855 treatment.&lt;/p&gt;
Accurate determination of minority carrier- and lattice scattering-mobility in silicon from photoconductance decay (1992)

Accurate measurements of the minority carrier- and lattice scattering-diffusion constant and mobility in float zone silicon have been determined using photoconductance decay. For the more lightly doped specimens our results indicate slightly higher mobility than published majority carrier values. This is attributed to purer samples which allow a more accurate measurement of the lattice scattering mobility. In the dopant range 1015–1017 cm−3 the results for both electrons and holes are, within experimental error, equal to the majority carrier values. Unlike other methods this technique is a very direct measurement of the diffusion constant as only the thickness and decay time of the wafer need to be determined. The method is estimated to have a one standard deviation uncertainty of 2%–4% which is comparable to the best accuracy previously obtained for majority carrier measurements.
Scheduling Predictability In I-DEVS By Schedulability Analysis (2016)

The Imprecise DEVS approach combines the advantages of imprecise computation with a formal modeling methodology in order to avoid the transient overloads on real-time systems. This process requires efficient scheduling methods to find the best schedule of the computations to guarantee the deadlines and to increase the quality of the results by reducing the discarding of the optional computations. This work introduces a solution to integrate schedulability analysis with Imprecise DEVS to improve the predictability and the feasibility for scheduling. The proposed schedulability analysis and scheduling methods are based on Earliest Deadline First, priority-driven and mandatory-first approaches and they are considered to be executed dynamically. The schedulability tests contribute to avoid unnecessary discarding of optional computations improving the quality of the results.
Clinical features and outcome in dogs and cats with obsessive-compulsive disorder: 126 cases (1989–2000) (2002)

OCD in dogs does not appear to be associated with lack of training, lack of household stimulation, or social confinement. In cats, OCD may be associated with environmental and social stress. Obsessive-compulsive disorder appears at the time of social maturity and may have sporadic and heritable forms. With appropriate treatment (consistent behavior modification and treatment with clomipramine), frequency and intensity of clinical signs in most dogs and cats may decrease by > 50%. Success appears to depend on client understanding and compliance and the reasonable expectation that OCD cannot be cured, but can be well controlled.
Placental Abruption among Singleton and Twin Births in the United States: Risk Factor Profiles (2001)

The authors performed a population-based epidemiologic study to evaluate and contrast risk factor profiles for placental abruption among singleton and twin gestations. Data were derived from linked US birth/infant death files for 1995 and 1996, comprising 7,465,858 singleton births and 193,266 twin births. The authors also evaluated effect modification between smoking and hypertension and the effect of a dose-response relation with number of cigarettes smoked daily on abruption risk. Abruption was recorded in 5.9 per 1,000 singleton births and 12.2 per 1,000 twin births. Risk factors for abruption among singleton and twin births, respectively, included preterm premature rupture of membranes (adjusted relative risks (RRs) = 4.89 and 2.01), eclampsia (RRs = 3.58 and 1.67), anemia (RRs = 2.23 and 2.33), hydramnios (RRs = 2.04 and 1.66), renal disorders (RRs = 1.54 and 2.56), and intrapartum fever (>100 degrees F) (RRs = 1.17 and 1.69). Chronic hypertension (RR = 2.38) and pregnancy-induced hypertension (RR = 2.34) were risk factors for abruption in singleton births but not in twin births. Number of cigarettes smoked daily demonstrated a dose-response trend for abruption risk in singletons and twins. Abruption was more likely to occur among smokers with chronic hypertension (RRs = 4.66 and 3.15) and eclampsia (RRs = 6.28 and 5.08). The authors conclude that abruption is twice as likely to occur in twins as in singletons with differing risk factor profiles. This suggests that abruption in twins may result from different pathophysiologic processes.
Investigation of the Component Reactions of Oxidative Sterol Demethylation (1968)

Abstract The initial reaction of 4-methylsterol demethylation is an aerobic hydroxylation of the methyl group by a mixed function oxidase. Since the microsomal carbon monoxidebinding hemoprotein, P-450, is the terminal oxidase of some similar mixed function oxidases, the role of P-450 in the process of methylsterol demethylation has now been investigated. The specific content of P-450 in a preparation of rat liver microsomes that actively demethylates sterols is approximately 1.2 mµmoles per mg of protein. This concentration of microsomal P-450 is decreased markedly by treatment of microsomes with deoxycholic acid. However, upon deoxycholate treatment, methylsterol demethylase activity is retained disproportionately. Microsomes from various sources contain sterol demethylase activity, but many active preparations contain no P-450. The sterol demethylase is not inhibited by compounds that inhibit P-450-dependent mixed function oxidases. For example, methylsterol demethylase is not inhibited by carbon monoxide, ethyl isocyanide, or nicotinamide. In further contradistinction, the demethylase is inhibited by cyanide. An aerobic hydroxylase is released from rat liver microsomes in soluble form by treatment of the particles with deoxycholic acid. The isolated hydroxylase has been purified approximately 100-fold by gel filtration, ammonium sulfate fractionation, and chromatography on diethylaminoethyl Sephadex. The ratio of activity to P-450 content is increased approximately 1000-fold by purification. Similar but less extensive evidence suggests that microsomal cytochrome b5 may not be a carrier of electrons in methylsterol hydroxylase.
Biological markers for formaldehyde exposure in mortician students. Report 1. Documentation of measurement methodology for characterizing extent of exposure. Final report (1992)

A methodology used to determine airborne formaldehyde (50000) exposure in mortician students performing embalmings was evaluated. Prior to field testing, a laboratory study was conducted to evaluate the performance of a passive diffusion device in determining formaldehyde concentrations. The passive diffusion device and the NIOSH active air sampling method provided comparable formaldehyde determinations in a dynamic vapor generation chamber with a total analyte load of at least 8 parts per million hours. Field sampling studies under static air conditions revealed a negative bias and a higher imprecision among the passive monitors compared to the active sampling methods. Field tests under more turbulent air conditions resulted in continued negative bias, but similar precision. The bias observed between the passive diffusion device and the active air sampling methods may have been related to newly recognized forms of airborne formaldehyde. An average bias value calculation was used to adjust the subsequent extent of exposure study data obtained from the passive diffusion device. The authors conclude that the continuous reading passive diffusion device used to determine formaldehyde exposure performed in general agreement to the NIOSH active sampling methods, and could be used to monitor short term elevations in formaldehyde levels.
An Efficient Dispatcher for Large Scale GraphProcessing on OpenCL-based FPGAs (2018)

High parallel framework has been proved to be very suitable for graph processing. There are various work to optimize the implementation in FPGAs, a pipeline parallel device. The key to make use of the parallel performance of FPGAs is to process graph data in pipeline model and take advantage of on-chip memory to realize necessary locality process. This paper proposes a modularize graph processing framework, which focus on the whole executing procedure with the extremely different degree of parallelism. The framework has three contributions. First, the combination of vertex-centric and edge-centric processing framework can been adjusting in the executing procedure to accommodate top-down algorithm and bottom-up algorithm. Second, owing to the pipeline parallel and finite on-chip memory accelerator, the novel edge-block, a block consist of edges vertex, achieve optimizing the way to utilize the on-chip memory to group the edges and stream the edges in a block to realize the stream pattern to pipeline parallel processing. Third, depending to the analysis of the block structure of nature graph and the executing characteristics during graph processing, we design a novel conversion dispatcher to change processing module, to match the corresponding exchange point.
Relativistic Solitons and Pulsars (1975)

We consider solitons in which the electrons and/or the positive ions have relativistic random velocities and we discuss possible applications of such solitons to pulsar phenomena.
Therapeutic Effects of Hyaluronic Acid on Osteoarthritis of the Knee (2004)

Therapeutic study, Level II-3b (systematic review; nonhomogeneous Level-I studies). See Instructions to Authors for a complete description of levels of evidence.
Exploiting the information content of hydrological "outliers" for goodness-of-fit testing (2010)

Abstract. Validation of probabilistic models based on goodness-of-fit tests is an essential step for the frequency analysis of extreme events. The outcome of standard testing techniques, however, is mainly determined by the the behavior of the hypothetical model, FX(x), in the central part of the distribution, while the behavior in the tails of the distribution, which is indeed very relevant in hydrological applications, is relatively unimportant for the results of the tests. The maximum-value test, originally proposed as a technique for outlier detection, is a suitable, but seldom applied, technique that addresses this problem. The test is specifically targeted to verify if the maximum (or minimum) values in the sample are consistent with the hypothesis that the distribution FX(x) is the real parent distribution. The application of this test is hindered by the fact that the critical values for the test should be numerically obtained when the parameters of FX(x) are estimated on the same sample used for verification, which is the standard situation in hydrological applications. We propose here a simple, analytically explicit, technique to suitably account for this effect, based on the application of censored L-moments estimators of the parameters. We demonstrate, with an application that uses artificially generated samples, the superiority of this modified maximum-value test with respect to the standard version of the test. We also show that the test has comparable or larger power with respect to other goodness-of-fit tests (e.g., chi-squared test, Anderson-Darling test, Fung and Paul test), in particular when dealing with small samples (sample size lower than 20–25) and when the parent distribution is similar to the distribution being tested.
Variational approach to pulse propagation in parametrically amplified optical systems (1997)

A variational method to study pulse propagation and soliton formation in dissipative, nonlinear, and dispersive optical systems with parametric amplification is presented. The method clearly shows the important role that the frequency chirp plays in determining the nonlinear pulse dynamics and it is able to predict the emergence of a Hopf instability for the phase-locked solitary pulses observed in numerical simulations.
Supplementary Table 2 from Metabolic Profiling, a Noninvasive Approach for the Detection of Experimental Colorectal Neoplasia (2023)

&lt;p&gt;PDF file - 68K, The identity and effect size of changes (AOM vs. saline-treated mice) based on log transformed data are shown for biochemicals whose changes are significant in feces and colorectum, plasma and colorectum and all 3 matrices, 7 weeks after the last injection.&lt;/p&gt;
Clustering of cancer‐related mutations in a subset of BRCA1 alleles: A study in the Spanish population (2002)

We have observed that the frequency of D17S855 short alleles (139 bp and 141 bp) in individuals carrying BRCA1 germline mutations is higher than in controls (54% vs. 31%, p = 0.0004). By unambiguously establishing mutation/D17S855 phase in 18 BRCA1-positive families, we find that most (11 of 15 different mutations) BRCA1 defects are linked to chromosomes with short alleles (OR = 8.21, 95% CI 1.97-39.32, p = 0.0007). We suggest that BRCA1 mutations are not randomly distributed but clustered in a subset of BRCA1 alleles that can be identified by D17S855 genotyping. Further analysis involving a larger set of mutations and different populations are needed to clarify the relevance of this unexpected finding.