gebhart/patrepeval huggingface dataset:
Bromide impairs the circadian clock and glycolytic homeostasis via disruption of autophagy in rat H9C2 cardiomyocytes (2019)

Abstract Background Trace elements function as essential cofactors that are involved in various biochemical processes in mammals. Autophagy is vital for nutrient supplement, which is an important Zeitegber for the circadian homeostasis in heart. Here, we considered the possibility that autophagy, as well as the cardiomyocyte clock and glycolysis are interlinked. Detrimental effects were observed when cardiac system is exposed to bromine containing drugs. This study investigated the effects and mechanisms of bromide on the circadian clock and glycolytic metabolism of H9C2 cardiomyocytes. Methods H9C2 cardiomyocytes were incubated with sodium bromide at indicated doses for 24 hours, cell viability, mRNA expression of clock genes, glycolytic genes and autophagic genes were examined using various cellular and molecular approaches. Also, circadian oscillation rhythm of these genes was determined by serum shock with sodium bromide or equal amounts of sodium chloride. Results Bromide modestly affects cell viability and apoptosis of H9C2 cardiomyocytes. Bromide dampens the clock and glycolytic ( Hk2 and Pkm2 ) gene expression rhythmicity in a dose-dependent manner. Additionally, bromide inhibits autophagic process in H9C2 cardiomyocytes. In contrast, rapamycin (an autophagy inducer) dramatically restores the inhibitory effect of NaBr on the mRNA expression levels of clock genes ( Bmal1 , Cry1 and Rorα ) and glycolytic genes ( Hk2 and Pkm2 ). Conclusions Our results reveal that bromide represses the clock and glycolytic gene expression patterns, partially through inhibition of autophagy.
Superimposed Or Time-Multiplexed Training: A Performance Comparison (2009)

Publication in the conference proceedings of EUSIPCO, Glasgow, Scotland, 2009
Advanced Dual Probe Formation Tester with Transient, Harmonic, and Pulsed Time-Delay Testing Methods Determines Permeability, Skin, and Anisotropy (2000)

Three new pressure-transient testing methods are employed to determine horizontal and vertical permeability using a dual probe formation tester. Real-time interpretation during acquisition of pressure data, is the focus of all three new pressure-testing techniques. In the first, a new spherical flow model with anisotropy, storage, and skin is developed from first principles for dual probe analysis. Historically, pressure transient solutions are presented as Laplace transforms and approximated in the time domain using numerical techniques. Typically, early, intermediate and late time periods are identified using derivative plots; but very often, the selection of appropriate data results in confusion. Here, the Laplace transform is inverted to yield a single, exact, closed form, analytical, time domain solution valid for all times, making real-time parameter matching possible with high accuracy.The second technique uses an oscillatory displacement source at the piston face, and the phase delay of the pressure pulse between the probes is used to determine permeability and anisotropic index. This technique is particularly useful when the second monitoring probe signal is weak (as in high permeability zones) or where there is large spacing between the probes. Pulse timing can usually be detected more accurately than its magnitude, thus extending the range of permeability and anisotropic measurements. This methodology, which is based on a derived relationship between wave phase and permeability, was developed by mathematical analogy with resistivity determination methods used in induction logging.In the above method, it is often possible to encounter
Cytokine-Like Factor 1, an Essential Facilitator of Cardiotrophin-Like Cytokine:Ciliary Neurotrophic Factor Receptor α Signaling and sorLA-Mediated Turnover (2016)

Cardiotrophin-like cytokine:cytokine-like factor-1 (CLC:CLF-1) is a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development. Mice lacking CLC:CLF-1 die soon after birth due to a suckling defect and show reduced numbers of motor neurons. Humans carrying mutations in CLC:CLF-1 develop similar disorders, known as Sohar-Crisponi or cold-induced sweating syndrome, and have a high risk of early death. It is well known that CLC binds the ciliary neurotrophic factor receptor α (CNTFRα) and is a prerequisite for signaling through the gp130/leukemia inhibitory factor receptor β (LIFRβ) heterodimer, whereas CLF-1 serves to promote the cellular release of CLC. However, the precise role of CLF-1 is unclear. Here, we report that CLF-1, based on its binding site for CLC and on two additional and independent sites for CNTFRα and sorLA, is a key player in CLC and CNTFRα signaling and turnover. The site for CNTFRα enables CLF-1 to promote CLC:CNTFRα complex formation and signaling. The second site establishes a link between the endocytic receptor sorLA and the tripartite CLC:CLF-1:CNTFRα complex and allows sorLA to downregulate the CNTFRα pool in stimulated cells. Finally, sorLA may bind and concentrate the tripartite soluble CLC:CLF-1:CNTFRα complex on cell membranes and thus facilitate its signaling through gp130/LIFRβ.
Cluster‐determinant 36 (CD36) impacts on vitamin E postprandial response (2014)

Our findings show for the first time that CD36 participates-directly or indirectly-in vitamin E uptake, and that CD36 effect on postprandial lipid metabolism in turn modifies vitamin E postprandial response.
The Synthesis of Four-Bar Mechanisms by the Method of Components (1957)

Abstract The synthesis of four-bar mechanisms based on the vectorial representation of links in complex form was first suggested by S. Bloch. His work was further developed by R. Beyer and N. Rosenauer. These kinematicians investigated the synthesis of the four-bar mechanism for prescribed instantaneous angular velocities and accelerations of the three moving links. This paper presents a somewhat different approach to the problem, in that the vectors are being resolved into Cartesian components. This method permits the synthesis for prescribed conditions concerning angular velocities, accelerations, and lengths of links. The author believes that the simpler treatment will make this method more readily acceptable to engineers.
Spectral convergence in tapping and physiological fluctuations: coupling and independence of 1/f noise in the central and autonomic nervous systems (2014)

When humans perform a response task or timing task repeatedly, fluctuations in measures of timing from one action to the next exhibit long-range correlations known as 1/f noise. The origins of 1/f noise in timing have been debated for over 20 years, with one common explanation serving as a default: humans are composed of physiological processes throughout the brain and body that operate over a wide range of timescales, and these processes combine to be expressed as a general source of 1/f noise. To test this explanation, the present study investigated the coupling vs. independence of 1/f noise in timing deviations, key-press durations, pupil dilations, and heartbeat intervals while tapping to an audiovisual metronome. All four dependent measures exhibited clear 1/f noise, regardless of whether tapping was synchronized or syncopated. 1/f spectra for timing deviations were found to match those for key-press durations on an individual basis, and 1/f spectra for pupil dilations matched those in heartbeat intervals. Results indicate a complex, multiscale relationship among 1/f noises arising from common sources, such as those arising from timing functions vs. those arising from autonomic nervous system (ANS) functions. Results also provide further evidence against the default hypothesis that 1/f noise in human timing is just the additive combination of processes throughout the brain and body. Our findings are better accommodated by theories of complexity matching that begin to formalize multiscale coordination as a foundation of human behavior.
Role of sulfation in the formation of DNA adducts from N-hydroxy-2-acetylaminofluorene in rat liver in vivo. Inhibition of N-acetylated aminofluorene adduct formation by penta-chlorophenol (1981)

N-Hydroxy-2-acetylaminofluorene (N-OH-AAf) is metabolically converted into reactive N,O-esters which are capable of forming covalent adducts with DNA in rat liver in vivo. The effect of inhibiting one of the proposed pathways, N-O-sulfation, on DNA adduct formation was studied by using a specific sulfotransferase inhibitor, pentachlorophenol. Rats were pretreated with pentachlorophenol and, after 45 min, N-OH-AAF was administered. Four hours after dosing the animals were sacrificed and hepatic DNA was isolated. In DNA from control livers two acetylaminofluorene-and one aminofluorene-substituted deoxyguanosine adducts were found. The acetylaminofluorene derivatives, N-(deoxyguanosin-8-yl)-2--acetylaminofluorene and 3-(deoxyguanosin-N2-yl)-2acetylaminofluorene, accounted for 40% of the total binding in the hydrolyzed DNA. The aminofluorene adduct, N-(deoxyguanosin-8-yl)-2-aminofluorene, accounted for the remainder. In rats that were pretreated with pentacholorphenol, total DNA binding was decreased by 26%. The same three adducts were found, but the acetylaminofluorene adducts were now only 13% of the total, while the aminofluorene adduct accounted for 87%. The absolute amount of aminofluorene adduct was not altered as compared to control rats. These data demonstrate the involvement of N-O-sulfation in carcinogen-DNA binding and indicate that at least 70% of the acetylaminofluorene bound to deoxyguanosine in rat liver DNA, in vivo, is formed through N-O-sulfation of N-OH-AAF.
In vivo characterization of minipig skin as a model for dermatological research using multiphoton microscopy (2020)

Minipig skin is one of the most widely used non-rodent animal skin models for dermatological research. A thorough characterization of minipig skin is essential for gaining deeper understanding of its structural and functional similarities with human skin. In this study, three-dimensional (3-D) <i>in vivo</i> images of minipig skin was obtained non-invasively using a multimodal optical imaging system capable of acquiring two-photon excited fluorescence (TPEF) and fluorescence lifetime imaging microscopy (FLIM) images simultaneously. The images of the structural features of different layers of the minipig skin were qualitatively and quantitatively compared with those of human skin. Label-free imaging of skin was possible due to the endogenous fluorescence and optical properties of various components in the skin such as keratin, nicotinamide adenine dinucleotide phosphate (NAD(P)H), melanin, elastin, and collagen. This study demonstrates the capability of optical biopsy techniques, such as TPEF and FLIM, for <i>in vivo</i> non-invasive characterization of cellular and functional features of minipig skin, and the optical image-based similarities of this commonly utilized model of human skin. These optical imaging techniques have the potential to become promising tools in dermatological research for developing a better understanding of animal skin models, and for aiding in translational pre-clinical to clinical studies.
Stimuli-Responsive Materials: From Molecules to Nature Mimicking Materials Design (2016)

The ability for a material to change properties in response to external stimuli is an attractive feature for numerous applications and as such stimuli responsive materials are gaining attention across many different fields. This book introduces the concepts of stimuli-responsiveness, including the fundamental materials properties required for design. It provides readers with comprehensive scientific principles and developments of stimuli responsive materials, as well as the recent technological advances. Written by a renowned expert in the field, this book is suitable for anyone interested in stimuli responsive materials working in polymers, biochemistry, biotechnology and materials science.
Vaccines for preventing influenza in healthy adults (2004)

Influenza vaccines are effective in reducing serologically confirmed cases of influenza. However, they are not as effective in reducing cases of clinical influenza and number of working days lost. Universal immunisation of healthy adults is not supported by the results of this review.
The Role of the Annular Gap in Expandable Sand Screen Completions (2004)

Abstract When an expandable sand screen is installed, the gap between the outside of the screen and the rock can vary from zero upwards. The gap is influenced by the state of the hole after drilling, subsequent logging or completion operations, and the natures of the screen and expansion process. This paper describes experiments and modelling undertaken to help understand and clarify the impact of the gap on the short- and long-term integrity of the completion. Experiments measuring hole closure showed that the presence of a screen always improved hole stability relative to that of the open hole; this benefit was reduced when there was a significant annular gap. This conclusion was supported by rock deformation modelling, which showed that for a screen with relatively low radial stiffness, a very small or zero gap was best, while a stiff screen could tolerate a slightly larger gap, up to a few millimeters. In both cases this is to allow mobilization of rock strength through yielding. Gaps larger than this allow the rock to break up, potentially leading to point-loading or erosion problems. Modelling of the transport of liquid and sand showed that a smaller gap reduces annulus liquid velocity, ultimately to the point where sand transport (and potential erosion) no longer occurs. It also identified conditions that could compromise the long-tem integrity of the screen, such as blocked screen sections or regions of enlarged gap, which generate persistent regions of concentrated flow through the screen wall, again potentially leading to erosion problems. The experiments were carried out using a newly developed bistable sand screen1. This has been designed to conform as closely as possible to the borehole wall, and have a very low deployment force, but the conclusions are equally applicable to other types of screen.
Supplementary document for X-ray phase tomography with near-field speckles for three-dimensional virtual histology - 4749827.pdf (2020)

Supplementary Information
A Phenotypic Screening Approach in Cord Blood–Derived Mast Cells to Identify Anti-Inflammatory Compounds (2013)

Mast cells are unique hematopoietic cells that are richly distributed in the skin and mucosal surfaces of the respiratory and gastrointestinal tract. They play a key role in allergic inflammation by releasing a cocktail of granular constituents, including histamine, serine proteases, and various eicosanoids and cytokines. As such, a number of drugs target either inhibition of mast cell degranulation or the products of degranulation. To identify potential novel drugs and mechanisms in mast cell biology, assays were developed to identify inhibitors of mast cell degranulation and activation in a phenotypic screen. Due to the challenges associated with obtaining primary mast cells, cord blood-derived mononuclear cells were reproducibly differentiated to mast cells and assays developed to monitor tryptase release and prostaglandin D2 generation. The tryptase assay was particularly sensitive, requiring only 500 cells per data point, which permitted a set of approximately 12,000 compounds to be screened robustly and cost-effectively. Active compounds were tested for concomitant inhibition of prostaglandin D2 generation. This study demonstrates the robustness and effectiveness of this approach in the identification of potential novel compounds and mechanisms targeting mast cell-driven inflammation, to enable innovative drug discovery efforts to be prosecuted.
Carbon-13 NMR spectra of isomerized polybutadienes (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbon-13 NMR spectra of isomerized polybutadienesHsin Ta Wang, Tristram W. Bethea, and H. James HarwoodCite this: Macromolecules 1993, 26, 4, 715–720Publication Date (Print):February 1, 1993Publication History Published online1 May 2002Published inissue 1 February 1993https://pubs.acs.org/doi/10.1021/ma00056a024https://doi.org/10.1021/ma00056a024research-articleACS PublicationsRequest reuse permissionsArticle Views243Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Transcatheter closure of a mid-muscular ventricular septal defect with an Amplatzer VSD occluder device (1999)

A 5 year old girl with a haemodynamically significant mid-muscular ventricular septal defect (VSD) had successful transcatheter closure using the Amplatzer VSD occluder. This device passes through a small diameter sheath and can be easily retrieved or repositioned. These properties may make it a suitable device for closure of large mid-muscular defects in small children.
Growth of Celery (Apium graveolens var. dulce) as Influenced by Phosphite (2008)

Although Phosphite (PO_3; Phi) has recently been marketed as “superior P fertilizer” for a wide range of crops, the claim regarding its potential as a fertilizer is controversial. In this study, effects of Phi at both low (0.2 mM) and high (2 mM) rates on growth and phosphorus (P) supply of celery (Apium graveolens var. dulce) were investigated under either low phosphate (PO_4; Pi) (0.1 mM) or high Pi (0.5 mM) supply. The effect of Phi was found to be strongly dependent on the P nutrient status of the plants. Addition of Phi at both rates did not influence growth of high Pi-supplied plants. However, Phi at 2 mM significantly decreased both shoot and root growth of low Pi-supplied plants. Plants grown in this treatment showed bleaching of young leaves and death of root tips and root hairs as typical toxic symptoms of Phi. Shoot P concentration was highly increased by root application of Phi, suggesting that Phi was well absorbed by roots and mobile inside the plants but also corroborating that Phi did not provide P nutrition to celery plants. No beneficial effect on plant growth was detected from the use of this material.
Technology 1993-telecommunications (1993)

Significant events during 1992 are highlighted. Communication technologies began merging, with cable TV offering telephone service and telecommunication companies offering TV. Wireless personal communication systems (PCSs) got the green light when the 1992 World Administrative Radio Conference designed frequency bands for future mobile communications services, with provisions for such services to be handled via low-Earth-orbiting satellites, and the US Federal Communication Commission allocated frequencies in the 2 GHz band to the deployment of several emerging technologies, including PCSs. Multimedia communication took off with the introduction of new services. In optical communication, erbium-doped fiber amplifiers were installed in the world's longest repeaterless undersea link. Strained-layer multi-quantum-well lasers received increasing attention, due to the improved system and device properties they offer. Research on cheap optical interconnects and packages gained momentum.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Increased analytical sensitivity of RT-PCR of PSA mRNA decreases diagnostic specificity of detection of prostatic cells in blood (1997)

The diagnostic specificity of the detection of disseminated prostatic cells by reverse-transcriptase polymerase chain reaction (RT-PCR) of PSA mRNA was investigated. A sensitive nested PCR was developed. In blood samples from 10 healthy female and 10 healthy male persons examined by RT-PCR, mRNA of PSA was detected 3 times in each group. In the groups of patients suffering from benign prostate hyperplasia and prostate cancer, 6 of 11 and 5 of 12, respectively, gave positive RT-PCR results. With increasing analytical sensitivity of the RT-PCR of PSA mRNA, the diagnostic specificity of the assay is decreased. Further development of this diagnostic method requires the introduction of the quantitative PCR which may make possible discrimination between prostatic and non-prostatic source of PSA mRNA by quantification.
The Role of MicroRNAs in the Regulation of Gastric Cancer Stem Cells: A Meta-Analysis of the Current Status (2019)

Gastric cancer (GC) remains one of the major causes of cancer-related mortality worldwide. As for other types of cancers, several limitations to the success of current therapeutic GC treatments may be due to cancer drug resistance that leads to tumor recurrence and metastasis. Increasing evidence suggests that cancer stem cells (CSCs) are among the major causative factors of cancer treatment failure. The research of molecular CSC mechanisms and the regulation of their properties have been intensively studied. To date, molecular gastric cancer stem cell (GCSC) characterization remains largely incomplete. Among the GCSC-targeting approaches to overcome tumor progression, recent studies have focused their attention on microRNA (miRNA). The miRNAs are short non-coding RNAs which play an important role in the regulation of numerous cellular processes through the modulation of their target gene expression. In this review, we summarize and discuss recent findings on the role of miRNAs in GCSC regulation. In addition, we perform a meta-analysis aimed to identify novel miRNAs involved in GCSC homeostasis.