gebhart/patrepeval huggingface dataset:
Antwerpen Noordersingel 3: Resten van de caponnière op front 4-5 van de Brialmontomwalling Eindverslag van een toevalsvondst. (2023)

Bij de uitbreiding van een slibverswerkingsinstallatie van de RWZI aan de Noordersingel 1-3 in Antwerpen, stootten arbeiders op de muurresten van de 19de-eeuwse Grote Omwalling, beter gekend als Brialmont omwalling. In het kader van deze toevalsvondst volgde een archeologisch onderzoek om de resten in kaart te brengen en de bouwtechnische kenmerken van de constructie te bestuderen.
Assembly of arrays of individual lateral nanotube emitters on nanoelectrodes (2005)

Composite AC - DC dielectrophoresis (DEP) is used to assemble arrays of individual multi-walled carbon nanotubes (MWNTs) onto gold nanoelectrodes. The nanoelectrodes are fabricated on silicon chips using electron-beam lithography. Using suitably designed electrodes for DEP or by electrical breakdown of the assembled nanotubes, individual nanotubes with one end end protruding from an electrode and the other end in proximity to another electrode are realized. Such nanotube arrays can be used as lateral field emitters, nanorelays and in other nanoelectromechanical systems (NEMS).
Blending and characterizations of microbial poly(3‐hydroxybutyrate) with dendrimers (2006)

Abstract Blending of microbial polyester poly(3‐hydroxybutyrate) (PHB) with various dendritic polyester oligomers or dendrimers was achieved by solution casting to improve the film forming ability of PHB. Films of the blends were characterized by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), scanning electron micrograph (SEM), and Fourier transform infrared spectroscopy (FTIR). It was revealed that there were mainly two types of interactions in the blending system: the plasticizing or lubricating effect of the low melting spherical dendrimers molecules improved the polymer chain mobility through the suppression of PHB crystallization in the blends; The dendrimers also functioned as crosslinking agents or antiplasticizing agents via weak hydrogen bonding to enhance the overall intermolecular interactions which decrease the chain mobility and thus cause the increase of glass transition temperature ( T g ) of PHB. TGA results concluded that incorporating the dendrimers could retard the thermal decomposition of PHB and enhanced its thermal stability accordingly. With the above blend processes, the so‐obtained PHB possessed better film forming ability and even patterned surface structures. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 102:3782–3790, 2006
The SPES surface ionization source (2017)

Ion sources and target systems play a crucial role in isotope separation on line facilities, determining the main characteristics of the radioactive ion beams available for experiments. In the context of the selective production of exotic species (SPES) facility, a 40 MeV, 200 μA proton beam directly impinges a uranium carbide target, generating approximately 10<sup>13</sup> fissions per second. The radioactive isotopes produced by the <sup>238</sup>U fissions are delivered to the 1+ ion source by means of a tubular transfer line. Here they can be ionized and subsequently accelerated toward the experimental areas. In this work, the characterization of the surface ionization source currently adopted for the SPES facility is presented, taking as a reference ionization efficiency and transversal emittance measurements. The effects of long term operation at high temperature are also illustrated and discussed.
The Solubility in Water of the Barium, Calcium, and Magnesium Salts of Sulfamic Acid. (1941)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Solubility in Water of the Barium, Calcium, and Magnesium Salts of Sulfamic Acid.G. Brooks King and John F. HooperCite this: J. Phys. Chem. 1941, 45, 6, 938–942Publication Date (Print):June 1, 1941Publication History Published online1 May 2002Published inissue 1 June 1941https://doi.org/10.1021/j150411a007Request reuse permissionsArticle Views354Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (241 KB) Get e-Alerts
Time-resolved quantum measurements using active detectors (1998)

Time-resolved quantum measurements using active detectors are analyzed. It is shown that the time-resolved observation of a quantum field leads to a mode mismatch between observed field and detection device that unavoidably introduces vacuum modes into the measurement. When active detectors are used, this gives rise to considerable background noise. The same conclusion may be drawn when considering other highly resolved quantum measurements of, e.g., energy, position, etc. Special emphasis is put on the analysis of time-resolved optical homodyne detection as an important example of an active detector.
TRPM2 ion channels steer neutrophils towards a source of hydrogen peroxide (2021)

Neutrophils must navigate accurately towards pathogens in order to destroy invaders and thus defend our bodies against infection. Here we show that hydrogen peroxide, a potent neutrophil chemoattractant, guides chemotaxis by activating calcium-permeable TRPM2 ion channels and generating an intracellular leading-edge calcium "pulse". The thermal sensitivity of TRPM2 activation means that chemotaxis towards hydrogen peroxide is strongly promoted by small temperature elevations, suggesting that an important function of fever may be to enhance neutrophil chemotaxis by facilitating calcium influx through TRPM2. Chemotaxis towards conventional chemoattractants such as LPS, CXCL2 and C5a does not depend on TRPM2 but is driven in a similar way by leading-edge calcium pulses. Other proposed initiators of neutrophil movement, such as PI3K, Rac and lyn, influence chemotaxis by modulating the amplitude of calcium pulses. We propose that intracellular leading-edge calcium pulses are universal drivers of the motile machinery involved in neutrophil chemotaxis.
RASSF1A gene promoter methylation in esophageal cancer specimens (2005)

SUMMARY. RASSF1A is frequently inactivated by promoter methylation in human cancers. To understand the involvement of the RASSF1A gene in esophageal squamous cell cancer (ESCC), we investigated the methylation of the RASSF1A gene in primary ESCC to define the frequency of this epigenetic aberration and its clinicopathological significance. Methylation-specific polymerase chain reaction (MSP) was used to detect RASSF1A gene methylation in DNA from 55 cases of ESCC. Methylation of the RASSF1A gene was found in 13 of 55 (24%) cases of primary ESCC. No association was found between the promoter methylation of the RASSF1A gene in primary ESCC and age, gender, localization, invasion depth, or tumor stage. Association was found with tumor differentiation. There was no correlation with its prognosis. In conclusion, it was suggested that an inactivation of the RASSF1A gene due to promoter methylation was associated with de-differentiation of the tumor in ESCC.
Nemchinov-Dyson Solutions of the Two-Dimensional Axisymmetric Inviscid Compressible Flow Equations [Review] (2020)

We investigate the two-dimensional (2D) inviscid compressible flow equations in axisymmetric coordinates, constrained by an ideal gas equation of state (EOS). Beginning with the assumption that the 2D velocity field is space-time separable and linearly variable in each corresponding spatial coordinate, we proceed to derive an in nite family of elliptic or hyperbolic, uniformly expanding or contracting \gas cloud" solutions. Construction of specific example solutions belonging to this family is dependent on the solution of a system of nonlinear, coupled, second-order ordinary differential equations, and the prescription of an additional physical process of interest (e.g., uniform temperature or uniform entropy flow). The physical and computational implications of these solutions as pertaining to quantitative code verification or model qualification studies are discussed in some detail.
Brain indoleamine 2,3-dioxygenase contributes to the comorbidity of pain and depression (2012)

Pain and depression are frequently comorbid disorders, but the mechanism underlying this association is unknown. Here, we report that brain indoleamine 2,3-dioxygenase 1 (IDO1), a rate-limiting enzyme in tryptophan metabolism, plays a key role in this comorbidity. We found that chronic pain in rats induced depressive behavior and IDO1 upregulation in the bilateral hippocampus. Upregulation of IDO1 resulted in the increased kynurenine/tryptophan ratio and decreased serotonin/tryptophan ratio in the bilateral hippocampus. We observed elevated plasma IDO activity in patients with both pain and depression, as well as in rats with anhedonia induced by chronic social stress. Intra-hippocampal administration of IL-6 in rats, in addition to in vitro experiments, demonstrated that IL-6 induces IDO1 expression through the JAK/STAT pathway. Further, either Ido1 gene knockout or pharmacological inhibition of hippocampal IDO1 activity attenuated both nociceptive and depressive behavior. These results reveal an IDO1-mediated regulatory mechanism underlying the comorbidity of pain and depression and suggest a new strategy for the concurrent treatment of both conditions via modulation of brain IDO1 activity.
Spectroelectrochemical cell with adjustable solution layer thickness (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSpectroelectrochemical cell with adjustable solution layer thicknessMarc D. Porter, Shaojung. Dong, Yupeng. Gui, and Theodore. KuwanaCite this: Anal. Chem. 1984, 56, 12, 2263–2265Publication Date (Print):October 1, 1984Publication History Published online1 May 2002Published inissue 1 October 1984https://pubs.acs.org/doi/10.1021/ac00276a068https://doi.org/10.1021/ac00276a068research-articleACS PublicationsRequest reuse permissionsArticle Views98Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Hypothyroidism and anti‐endothelial cell antibodies (1993)

Because of our previous demonstration of anti-endothelial cell antibodies (AECA) in patients with insulin-dependent diabetes mellitus and their association, in this condition, with thyroid disease, we sought these antibodies in patients with suspected thyroid dysfunction using an enzyme immunoassay with human umbilical vein endothelial cells as the substrate. AECA were found in 5/120 (4.2%) patients with normal and 15/97 (15.4%) with abnormal thyroid function. The increased prevalence in the latter group was due to a highly significant association between the presence of AECA and raised levels of TSH. We conclude that a highly significant correlation exists between the levels of AECA and TSH, but not between those of AECA and fT4. Patients with hypothyroidism as defined by high levels of TSH have AECA significantly more often than patients with low or normal TSH (22.2% versus 2.8% and 5.8%).
Abstract 4150: Novel preclinical model for the evaluation of cytokine release syndrome in response to CD19xCD3 bispecific antibody in humanized mice (2023)

Abstract Cytokine Release Syndrome (CRS) is a systemic inflammatory response that is caused by the large, rapid release of cytokines in the blood by immune cells affected by infection or immunotherapy and remains a prominent challenge for T cell-based therapeutics. Bispecific T cell engagers (BiTEs) are fusion proteins that are generated by linking the targeting region of two antibodies: one arm binds to the tumor-associated antigen, and the other arm binds to T cells to promote T cell-mediated cytotoxicity in an MHC-independent manner. A CD19xCD3 BiTE has been approved by the FDA for the treatment of CD19-positive B-cell lymphoma. Despite having great clinical efficacy, CRS remains a major concern for BiTE therapy. This necessitates the development of a translational model that could predict CRS toxicity more accurately. Various in-vitro models proposed to assess BiTE-related CRS have several shortcomings as they do not provide details about the systemic immune response, off-target effects, neurotoxicity, tissue damage, and organ failure. Here we propose an in-vivo approach to concomitantly assess the efficacy and CRS toxicity of CD19xCD3 BiTE either alone or in combination with Rituximab (monoclonal antibody targeting CD20) in the Raji luciferase xenograft model of Burkitt’s lymphoma in PBMC humanized NSG-MHC Class I/II knockout mice. Five days post human PBMC engraftment (Study Day- SD 5), the mice were injected with Raji-luciferase cells. On SD 6, the mice were treated with BiTE, Rituximab, or the combination of BiTE and Rituximab. Additional control groups included OKT3 and Anti-CD28, the anti-T cell antibodies that failed clinically due to severe CRS. Efficacy was assessed through in-vivo imaging on SD5, SD8, and SD11. We observed tumor growth inhibition with BiTE, Rituximab, and the combination treatment. Clinical observations were recorded daily post treatment. Following cytokines were measured 6 hours after dosing and at study termination - IL-2, IL-4, IL-6, IL-10, TNF-α, and IFN-γ. Elevated cytokine levels were observed in the BiTE/combination group 6 hours post dosing but not in the Rituximab alone group. Together, the data suggest that the model could be used to assess the preclinical efficacy and CRS toxicity of BiTE. Citation Format: Deep S. Shah, Catalina Simion, Sang hu, Rhonda Chronis, Tre McClellan, Jae Hwang, Ryan Yang, Heather Baker, Danying Cai, James Keck, Lindsay Shopland. Novel preclinical model for the evaluation of cytokine release syndrome in response to CD19xCD3 bispecific antibody in humanized mice. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 4150.
Structural dynamics of the myosin relay helix by time-resolved EPR and FRET (2009)

We have used two complementary time-resolved spectroscopic techniques, dipolar electron-electron resonance and fluorescence resonance energy transfer to determine conformational changes in a single structural element of the myosin motor domain, the relay helix, before and after the recovery stroke. Two double-Cys mutants were labeled with optical probes or spin labels, and interprobe distances were determined. Both methods resolved two distinct structural states of myosin, corresponding to straight and bent conformations of the relay helix. The bent state was occupied only upon nucleotide addition, indicating that relay helix, like the entire myosin head, bends in the recovery stroke. However, saturation of myosin with nucleotide, producing a single biochemical state, did not produce a single structural state. Both straight and bent structural states of the relay helix were occupied when either ATP (ADP.BeF(x)) or ADP.P(i) (ADP.AlF(4)) analogs were bound at the active site. A greater population was found in the bent structural state when the posthydrolysis analog ADP.AlF(4) was bound. We conclude that the bending of the relay helix in the recovery stroke does not require ATP hydrolysis but is favored by it. A narrower interprobe distance distribution shows ordering of the relay helix, despite its bending, during the recovery stroke, providing further insight into the dynamics of this energy-transducing structural transition.
Generation and field-resolved detection of ultrafast synthetic multi-THz transients (2013)

With the availability of intense and stable femtosecond sources, the modern focus of ultrafast science has been shifting toward precise coherent control of light-matter interaction on the fundamental time scales. Such control necessarily entails the ability to generate phase-stable symmetry-broken synthetic optical waveforms. The most direct approach to accomplish this is to superpose a fundamental field with its even-harmonic, while exercising control of their relative phase. To this end, it has been already demonstrated that synthetic ω-2ω pulses drastically enhance XUV and THz generation in gas plasmas, as well as allow for control of quantum interference currents in semiconductors. In this work we demonstrate generation and field-resolved detection of strongly symmetry-broken highintensity synthetic multi-THz transients for the first time.
Cooling of spherical products: Part II—heat transfer parameters (1995)

This paper presents a study on the determination of the heat transfer parameters, namely surface heat transfer coefficients, thermal conductivities, thermal diffusivities, specific heats and Biot numbers, for the individual product being cooled with water and with air. An analytical model was developed to determine the surface heat transfer coefficients of the products depending on the thermal properties and cooling process parameters. The results of the present study indicate that surface heat transfer coefficients decrease with increasing batch weight in water cooling and increase with increasing air flow velocity in air cooling. The proposed model can be used to determine easily and accurately surface heat transfer coefficients of different spherically shaped objects subjected to cooling.
COX-2 Inhibitors Suppress Activation of NF-κB in Gastric Cancer (2006)

Objective To observe the inhibitory effects in vivo of nonsteroidal antiinflammatory drugs(NSAIDs) on activation of NF-κB in gastric cancer of animal model,further to investigate their anti-cancer mechanisms.Methods Thirty athymic mice's xenograft models with human gastric cancer cell SGC7901 were established and divided randomly into three groups: sulindac group(8 mg),celecoxib group(10 mg),and control group(Arabic gel 50 mg).TransAM NFκB p50 Transcription Factor Assay Kit was applied to detect the level of activating NF-κB.Results Sulindac and celecoxib both markedly depressed the activation of NF-κB.The ANOVA analysis showed the activating NF-κB levels of both sulindac and celecoxib groups(0.46 ± 0.31,0.23 ± 0.08,respectively) were significantly lower than that of control group(0.84 ± 0.58,F = 3.98 and F = 3.65,P0.05 in both),but no differences of activating NF-κB level showed between two drug groups.Conclusion The NSAIDs had obvious anti-cancer effects in vivo against gastric cancer,and inhibiting the activation of NF-κB might be one of their anti-cancer mechanisms.
Spatial frequency–based correction of the spherical aberration in living brain imaging (2023)

Optical errors, including spherical aberrations, hinder high-resolution imaging of biological samples due to biochemical components and physical properties. We developed the Deep-C microscope system to achieve aberration-free images, employing a motorized correction collar and contrast-based calculations. However, current contrast-maximization techniques, such as the Brenner gradient method, inadequately assess specific frequency bands. The Peak-C method addresses this issue, but its arbitrary neighbor selection and susceptibility to the noise limit its effectiveness. In this paper, we emphasize the importance of a broad spatial frequency range for accurate spherical aberration correction and propose Peak-F. This spatial frequency-based system utilizes a fast Fourier transform as a bandpass filter. This approach overcomes Peak-C's limitations and comprehensively covers the low-frequency domain of image spatial frequencies.
An intelligent ETL workflow framework based on data partition (2010)

ETL tool is an important part to build a data warehouse and data centers. For massive data processing, this paper presents an intelligent ETL workflow framework based on the distributed computing servers, adding an intelligent manipulative module, acquiring the data of the system efficiency and resources, operating data, dynamically adjusting the ETL strategy, and doing corresponding data segmentation for larger jobs, realizing workflow optimization for multi-machine parallel execution, improving operational efficiency, and facilitating error recovery. Intelligent control module is composed of the monitor, knowledge base, and the selector. The source data horizontal partition is the basis and difficulty to achieve multi-machine parallel.
Low Expression in Xenopus Oocytes and Unusual Functional Properties of α1β2γ2 GABAA Receptors with Non-Conventional Subunit Arrangement (2017)

The major subunit isoform of GABAA receptors is α1β2γ2. The subunits are thought to surround an ion pore with the counterclockwise arrangement α1γ2β2α1β2 as seen from the outside of the neuron. These receptors have two agonist sites and one high affinity drug binding site specific for benzodiazepines. Recently, this receptor was postulated to assume alternative subunit stoichiometries and arrangements resulting in only one agonist site and one or even two sites for benzodiazepines. In order to force a defined subunit arrangement we expressed a combination of triple and dual concatenated subunits. Here we report that these unconventional receptors express only small current amplitudes in Xenopus oocytes. We determined agonist properties and modulation by diazepam of two of these receptors that resulted in currents large enough for a characterization, that is, β2-α1-γ2/α1-γ2 and β2-α1-γ2/β2-γ2. The first pentamer predicted to have two benzodiazepine binding sites shows similar response to diazepam as the standard receptor. As expected for both receptors with a single predicted agonist site the concentration response curves for GABA were characterized by a Hill coefficient < 1. β2-α1-γ2/β2-γ2 displayed a mM apparent GABA affinity for channel opening instead of the expected μM affinity. Based on their subunit and binding site stoichiometry, that contradicts all previous observations, their unusual functional properties and their very low expression levels in oocytes, we consider it unlikely that these unconventional receptors are expressed in neurons to an appreciable extent.