gebhart/patrepeval huggingface dataset:
Mixed-Mode Strength of Thin Adhesive Films: Experimental Characterization Through a Tubular Specimen with Reduced Edge Effect (2013)

The present work deals with the characterization of adhesives in thin film under uniform and multi-axial loading conditions. The tests are carried out with a tubular butt bonded specimen, previously developed by the authors, which ensures both shear and normal uniform stress fields inside the adhesive layer. Stress analysis is performed analytically and shows that, in addition to the axial stress, both radial and circumferential stress components are present in the adhesive layer due to Poisson's effect. This leads to a high level of stress triaxiality especially when only axial loading is considered. The experimental tests performed on eight different loading modes show that the adhesive behaves better under shear stress rather than under normal tensile stress, and its strength increases under compressive mixed mode loading. Among literature criteria for equivalent stress, the Stassi D'Alia criterion provides a clear equivalent failure stress value for the adhesive here examined, regardless of the stress triaxiality.
ChemInform Abstract: GLYCOSYL IMIDATES. 18. REGIOSELECTIVE REACTIONS OF PARTIALLY PROTECTED SUGARS. CONVENIENT SYNTHESIS OF 3,4‐DIAZIDO‐3,4‐DIDEOXY‐L‐ARABINOSE FROM D‐ARABINOSE (1985)

Abstract Bei Reaktion des Arabinopyranosids (Ia) mit MesCl oder TosCl beobachtet man die Bildung der Derivate (Ib) bzw. (Ic) und (Id) unter Beteiligung der beiden vicinalen OH‐Gruppen an C‐2 und C‐3, während eine Silylierung die Derivate (Id) und (le) ergibt.
Alkaloids from Microcos paniculata with Cytotoxic and Nicotinic Receptor Antagonistic Activities (2013)

Microcos paniculata is a large shrub or small tree that grows in several countries in South and Southeast Asia. In the present study, three new piperidine alkaloids, microgrewiapines A-C (1-3), as well as three known compounds, inclusive of microcosamine A (4), 7'-(3',4'-dihydroxyphenyl)-N-[4-methoxyphenyl)ethyl]propenamide (5), and liriodenine (6), were isolated from cytotoxic fractions of the separate chloroform-soluble extracts of the stem bark, branches, and leaves of M. paniculata. Compounds 1-6 and 1a (microgrewiapine A 3-acetate) showed a range of cytotoxicity values against the HT-29 human colon cancer cell line. When evaluated for their effects on human α3β4 or α4β2 nicotinic acetylcholine receptors (nAChRs), several of these compounds were shown to be active as nAChR antagonists. As a result of this study, microgrewiapine A (1) was found to be a selective cytotoxic agent for colon cancer cells over normal colon cells and to exhibit nicotinic receptor antagonistic activity for both the hα3β4 and hα4β2 receptor subtypes.
Laser photobiomodulation of wound healing: new findings with an improved animal model (2011)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Philip V. Peplow, Tzu‐Yun Chung, G. David Baxter; Laser photobiomodulation of wound healing: new findings with an improved animal model. AIP Conference Proceedings 24 August 2011; 1364 (1): 167–171. https://doi.org/10.1063/1.3626927 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
ChemInform Abstract: Synthesis of the Titanium Phosphide Telluride Ti2PTe2: A Thermochemical Approach. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Synthesis of Diacetal Trioxa-Cage Compounds via a Sequential Cyclization Reaction of Norbornene Derivatives Induced by Electrophiles (1997)

The synthesis of diacetal trioxa-cage compounds via a sequential cyclization reaction of norbornene derivatives induced by electrophiles in a short sequence is reported. Treatment of the norbornene derivatives 2a−d and 10b with I2 in aqueous THF in the presence of KI at 25 °C regioselectively gave the iodo-cage compounds 3a−d and 11 in 80−90% yields, respectively, via a iodine-induced sequential cyclization reaction. No detectable amount of other regioisomers or monocyclization products was obtained. The synthesis of trioxa-cages 14a−e was accomplished from 3a−d and 11 in a two-step sequence. Treatment of diacylnorbornenes 15a−f with I2 in aqueous THF at 25 °C regioselectively and stereoselectively gave the sequential cyclization products 16a−f, respectively, which were converted in one step to the diacetal trioxa-cages 24a−f in high yields. The structure of these trioxa-cages was proven by X-ray analysis of the crystalline compound 14e. Other electrophiles, such as bromine, m-CPBA, and Hg(OAc)2, were also found to be effective for the sequential cyclization reaction. Oxymercuration of 15a−f and 2a−c with Hg(OAc)2 in aqueous THF followed by reduction with NaBH4 at 25 °C gave compounds 28a−f and 30b,d,c in high yields, respectively.
Melanoma inhibitory activity (2002)

The aim of this study was to evaluate the tumour-associated antigen melanoma inhibitory activity (MIA) as a potential novel serological tumour marker in primary and metastatic uveal melanoma in both the laboratory and the clinical setting. In the laboratory setting, immunohistochemical staining with MIA antibody was performed in paraffin-embedded tissues from six amelanotic uveal melanomas and eight metastatic lesions of uveal melanomas. In the clinical setting, serum samples of 139 patients with uveal melanoma were examined; eight of these patients had overt metastatic disease. Sixty-one initially metastatic disease-free patients were followed over time (median follow-up 240 days, 95% confidence interval 60–883 days) and MIA levels were assessed repeatedly. A one-step enzyme-linked immunosorbent assay was used to quantify the MIA serum levels. In the laboratory setting, five of the six primary uveal melanomas and seven of the eight metastatic lesions stained immunohistologically positive for MIA. In the clinical setting, the 131 patients without overt metastatic disease demonstrated a median serum concentration of MIA of 6.6 ng/ml. In the eight patients with overt metastatic disease, the median serum concentration of MIA was 26.28 ng/ml. This difference was highly statistically significant (P < 0.001, analysis of variance). During follow-up, three initially metastatic disease-free patients developed overt metastatic disease, and the MIA level increased from a median of 6.6 ng/ml before to 29.2 ng/ml after clinical detection of metastatic disease. In the 58 other patients, the serum level remained stable during the entire follow-up period. In conclusion, MIA is expressed in primary and metastatic lesions of uveal melanomas, and a statistically significant elevation in MIA serum levels in patients who develop metastatic disease due to uveal melanoma indicates its promising role as a serum marker for monitoring uveal melanoma patients for metastasis.
Anti-IL6 Antibody (ab) Based Strategies Improve the Management of HIV Negative Castleman’s Disease. (2004)

Abstract Castleman’s disease (CD) is a rare, non-clonal lymphoproliferative disorder featuring histologically hyaline-vascular (HV), plasmacytic (PC) or a mixed variant. Clinically, CD presents with localized lymphadenopathy (unicentric CD: UCD) or generalized lymphadenopathy often associated with constitutional symptoms (multicentric CD: MCD). The etiology of CD in HIV negative patients is not known, but elevated serum levels of IL6 are closely linked to the gravity of systemic manifestations of MCD. We present data on the largest CD series thus far reported with various treatment modalities, including anti-IL6 strategies. Between 1989 and 2004, 37 patients were referred to our institution with HIV-negative CD. None of the patients tested had evidence of HHV8 infection by serology or PCR. Eleven patients had UCD. The median age in UCD was 43 years (range 29–62) with a preponderance of non-white patients (ratio 4.5:1). All patients had HV disease except one who had PC variant. One patient did not receive any specific treatment and is lost to follow up. The other 10 patients all underwent complete surgical resection. Three patients were de-bulked prior to surgery with steroids, rituxan ±cytoxan (n=2) or radiotherapy (n=1). None of these patients has evidence of disease with a median follow up of 43 mths (range 12–140 mths). Twenty-six patients had MCD. The median age was 44 years (range: 19–87) with no racial preponderance. All presented with constitutional symptoms including fatigue, anorexia or low grade fever. MCD was equal distributed amongst histological types (HV versus PC/mixed disease) and was frequently associated with peripheral neuropathy (n=5). Bronchiolitis obliterans and pemphigus, amyloidosis and myeloma were each present in 1 respective patient. The OS in MCD was 8.8 yrs with no significant difference between HVD and PC/mixed variants. A group of 12 MCD patients was treated with steroids, chemotherapy and/or anti-CD20 ab had an OS of 42 months (range: 2–111). Four patients died, whilst 4 are alive and disease free at 48, 50, 96 and 111 months. A group of 5 MCD patients was treated with the anti-trypazonomiasis agent suramin, which has anti-IL6 properties, and 4 died. The fifth patient is a long-term survivor (108 mths) after rescue with anti-IL6 based ab therapy. Nine additional MCD patients received anti-IL6 based ab therapy; 2 died. The median OS survival in this group was 74 months (range: 10–168) with 4 patients in CR at 16, 84, 108 and 168 mths. Anti-IL6 based ab therapy was very effective in abrogating debilitating constitutional symptoms. In recent patients, FDG-PET scanning showed that involved lymph nodes visible by CT scan had differential metabolic activity. PET showed response to therapy earlier than on CT or could demonstrate residual activity in normal nodes. We conclude that 1) MCD often has HV type histology, 2) anti-IL6 based ab therapies hold considerable promise in the management of symptomatic MCD, and 3) PET-scanning is helpful in monitoring disease response and activity. Figure Figure
Studies on the Flower Pigments in Snapdragon, Antirrhinum majus L (1977)

Distribution of anthocyanins, especially 3-glucoside, in fifteen marketing cultivars with several pure bred strains of snapdragon was surveyed with chromatographic technique.In some strains derived from “Ball's Supreme Red” an adequate amount of 3-glucoside with 3-rutinoside was found. In fifteen marketing cultivars, a relatively large amount of cyanidin-3-glucoside was found in young petals of florets of two cultivars, and in others cyanidin or pelargonidin-3-glucoside was detected in only trace or no amount. Nevertheless, in such young flower petals of most cultivars and strains tested, 3-glucosides were detected.A quantity of two anthocyanins in each developmental stage of flower petals was investigated in a reddish purple strain containing a relatively large amount of cyanidin-3-glucoside. The results are summarized below.1. The amount of cyanidin-3-glucoside per floret was decreased significantly from the half open stage of petals in all cases, while cyanidin-3-rutinoside had still been increased to senescence.2. The ratio of 3-glucoside/3-rutinoside in palate was higher than in upper lip in all stages.3. Decrease of 3-glucoside and increase of 3-rutinoside in palate after flower opening were obviously slower than in upper lip.From these phenomenon, it was assumed that 3-glucoside would be the precursor of 3-rutinoside in this case.
60GHz VCOs with transmission line resonator in a 0.25&#x03BC;m SiGe BiCMOS technology (2008)

In this paper, two 60 GHz LC-VCOs are compared. The varactorless oscillators are identical except for the implementation of the inductors. One oscillator uses a traditional spiral inductor, the other oscillator uses a shorted transmission line as inductor. Although the spiral inductor is favorable in terms of quality factor and self-resonant frequency, the shorted transmission line offers superior isolation from the substrate. The solid ground shield of the transmission line offers reduced sensitivity to substrate interference. The 60 GHz VCO with shorted transmission line as inductor achieves a measured 22.6 dB lower power level of the main oscillator sideband for a given interference level. The experiment is performed in a BiCMOS process, but the results are also applicable to CMOS technologies.
Jaw Loading Response of Current ATDs (2009)

&lt;div class="htmlview paragraph"&gt;Biomechanical surrogates are used in various forms to study head impact response in automotive applications and for assessing helmet performance. Surrogate headforms include those from the National Operating Committee on Standards for Athletic Equipment (NOCSAE) and the many variants of the Hybrid III. However, the response of these surrogates to loading at the chin and how that response may affect the loads transferred from the jaw to the rest of the head are unknown. To address part of that question, the current study compares the chin impact response performance of select human surrogates to that of the cadaver.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;A selection of Hybrid III and NOCSAE based surrogates with fixed and articulating jaws were tested under drop mass impact conditions that were used to describe post mortem human subject (PMHS) response to impacts at the chin (Craig et al., 2008). Results were compared to the PMHS response with cumulative variance technique (&lt;span class="xref"&gt;Rhule et al., 2002&lt;/span&gt;). A Hybrid III based surrogate headform with an articulating jaw demonstrated the best overall performance of the surrogates evaluated.&lt;/div&gt;
Efficient Solution Of Parabolic Equations By Krylov Approximation Methods (1992)

. In this paper we take a new look at numerical techniques for solving parabolic equations by the method of lines. The main motivation for the proposed approach is the possibility of exploiting a high degree of parallelism in a simple manner. The basic idea of the method is to approximate the action of the evolution operator on a given state vector by means of a projection process onto a Krylov subspace. Thus, the resulting approximation consists of applying an evolution operator of very small dimension to a known vector which is, in turn, computed accurately by exploiting high-order rational Chebyshev and Pad&amp;apos;e approximations to the exponential. Because the rational approximation is only applied to a small matrix, the only operations required with the original large matrix are matrix-by-vector multiplications, and as a result the algorithm can easily be parallelized and vectorized. Further parallelism is introduced by expanding the rational approximations into partial fractions. Some ...
Optical Trapping and Stretching of Lipid Vesicles (2012)

We demonstrate a dual-beam fiber trap for optically stretching lipid vesicles encapsulated with poly(ethylene glycol) polymer solution. Vesicle deformations exhibit ranges of linear and non-linear response for applied peak stresses of ~7-60 mN/m2.
Functional genomics of Buchnera and the ecology of aphid hosts (2005)

Abstract In many animal groups, mutualistic bacterial symbionts play a central role in host ecology, by provisioning rare nutrients and thus enabling specialization on restricted diets. Among such symbionts, genomic studies are most advanced for Buchnera , the obligate symbiont of aphids, which feed on phloem sap. The contents of the highly reduced Buchnera genomes have verified its role in aphid nutrition. Comparisons of Buchnera gene sets indicate ongoing, irreversible gene losses that are expected to affect aphid nutritional needs. Furthermore, almost all regulatory genes have been eliminated, raising the question of whether and how gene expression responds to environmental change. Microarray studies on genome‐wide expression indicate that Buchnera has evolved some constitutive changes in gene expression: homologues of heat stress genes have elevated transcript levels in Buchnera (relative to other bacteria) even in the absence of stress. Additionally, the microarray results indicate that responses to heat stress and to amino acid availability are both few and modest. Observed responses are consistent with control by the few ancestral regulators retained in the genome. Initial studies on the role of host genes in mediating the symbiosis reveal distinctive expression patterns in host cells harbouring Buchnera . In the near future, a complete genome of pea aphid will accelerate progress in understanding the functional integration of aphid and Buchnera genomes. Although information for other insect symbioses is relatively limited, studies on symbionts of carpenter ants and tsetse flies indicate many similarities to Buchnera .
Chip scale packaging and redistribution (2002)

Packaging of electronic components is in a transitional phase due to the relentless progress of transistor integration that is going on in the semiconductor environment. While all manufacturers may want to transition directly to flip chip, for a number of reasons, that may not always be possible. There are areas, in electronic manufacturing, that are under pressure to increase packaging density and reduce size and weight. For these products, solutions that allow manufacturers to operate in an environment that is familiar while additional infrastructure for full flip chip is being implemented are valuable. Packaging solutions of this type are referred to as chip scale packages. The use of redistributed lines in the solder provides for the smallest possible chip scale package. This particular methodology for producing a chip scale package meets all of the criteria established for evaluating the worthiness of a CSP and can be manufactured today at the lowest possible cost.
Evaluation of Functional Underwear for Firefighter Clothing by Total Heat Loss (2013)

Synthetic textile such as polyester and poly-urethane has been used for underwear in terms of moisture release and function in underwear. However, the synthetic underwear has high risk for skin burns due to melting and shrinking by heat. Thermal protection and comfort in fire fighter protective clothing is always trading off, but fire fighters tend to use the synthetic underwear to feel comfort and function during firefighting operation without understanding of the risk for skin burns by the textile. Objective of this study is to investigate if the synthetic underwear plays a significant role in moisture and metabolic heat transfer within the fire fighter clothing by total heat loss measurement. Measurement of the total heat loss has been conducted by the ASTM F-1868 instrument (Kato-Tech, Co. Ltd., Japan). Three type of fire fighter clothing, one station wear, and five types of underwear have been used for the test. Test has been conducted for each clothing and combination of clothing. The results shows that range of total heat loss is 322.3 W/m 2 to 385.3 W/m 2 , 857.9 W/m 2 , 782.3 W/m 2 to 897.3 W/m 2 for three fire fighter clothing, one station wear and five underwear, respectively. However, when the fabrics of fire fighter clothing, station wear and underwear were piled up, the range of total heat loss decreased to 242.1 W/m 2 to 304.4 W/m 2 . The data indicates that the fire fighter's multi-layer fabric controls the heat and moisture transfer within fire fighter clothing and no positive contribution by any types of underwear.
Mouse models for retinal degeneration (2019)

Retina is a part of central nervous system. Retinal degeneration is characterized by the death of photoreceptor cells, causing partial vision loss or even blindness. Retinal degeneration includes inherited retinal degeneration such as retinitis pigmentosa (RP) and complex retinal degeneration such as diabetic retinopathy. In this talk, I will discuss the disease mechanisms and current treatment of inherited retinal degeneration. I will also discuss techniques for retinal degeneration in mouse models.&amp;nbsp; I will demonstrate how to dissect mouse retina and retinal pigment epithelial (RPE) cells.&amp;nbsp; &amp;nbsp;
Structure–Activity Relationship Study Reveals ML240 and ML241 as Potent and Selective Inhibitors of p97 ATPase (2013)

To discover more potent p97 inhibitors, we carried out a structure-activity relationship study of the quinazoline scaffold previously identified from our HTS campaigns. Two improved inhibitors, ML240 and ML241, inhibit p97 ATPase with IC(50) values of 100 nM. Both compounds inhibited degradation of a p97-dependent but not a p97-independent proteasome substrate in a dual-reporter cell line. They also impaired the endoplasmic-reticulum-associated degradation (ERAD) pathway. Unexpectedly, ML240 potently stimulated accumulation of LC3-II within minutes, inhibited cancer cell growth, and rapidly mobilized the executioner caspases 3 and 7, whereas ML241 did not. The behavior of ML240 suggests that disruption of the protein homeostasis function of p97 leads to more rapid activation of apoptosis than is observed with a proteasome inhibitor. Further characterization revealed that ML240 has broad antiproliferative activity toward the NCI-60 panel of cancer cell lines, but slightly lower activity toward normal cells. ML240 also synergizes with the proteasome inhibitor MG132 to kill multiple colon cancer cell lines. Meanwhile, both probes have low off-target activity toward a panel of protein kinases and central nervous system targets. Our results nominate ML240 as a promising starting point for the development of a novel agent for the chemotherapy of cancer, and provide a rationale for developing pathway-specific p97 inhibitors.
Reliability Estimates for The Minimum Data Set for Nursing Home Resident Assessment and Care Screening (MDS) (1995)

The MDS is a core set of items, definitions, and response categories used to assess all of the nation's 1.5 million nursing home residents who reside in facilities participating in the Medicare or Medicaid programs. Further, the Health Care Financing Administration (HCFA) has proposed a rule that would require facilities to computerize MDS data and submit it to state and federal agencies, paving the way for a national database. This article describes the process of testing the reliability of the MDS items in 13 nursing homes in five states. The results demonstrate that MDS data gathered in a research effort attain reliabilities that make such data useful. MDS items met a standard for excellent reliability (i.e., intraclass correlation of .7 or higher) in key areas of functional status, such as cognition, ADLs, continence, and diagnoses. Sixty-three percent of the items achieved reliability coefficients of .6 or higher. Eighty-nine percent of the items in the MDS achieved .4 or higher.