gebhart/patrepeval huggingface dataset:
Wide area monitoring and control for voltage assessment in smart grids with distributed generation (2013)

In this paper, the application of wide area measurement and control for voltage assessment of hybrid AC/DC smart grid is investigated. The power available from renewable energy assets and storage elements on the microgrids is utilized to maintain system voltage stability. The system under study consists of two DC microgrids coupled to a multi-bus AC system. The supervisory controller of each of the two microgrids continuously communicates with the main controller of the AC grid, sending the available amount of apparent power and receiving power commands. The AC grid is monitored and controlled using a wide area measurement system in which measurements of the different nodes in the system are synchronized to a unified pulse signal. In case of voltage violation at any of the buses, the minimum reactive power needed from each of the micrgrids in order to restore the voltage magnitude to a value that is between the permissible limits is determined in real time by solving an optimization problem. Simulation, as well as experimental, results are included to verify the validity of the proposed wide area control technique.
Predicting the Handle and Comfort of Military Clothing Fabrics from Sensory and Instrumental Data: Development and Application of New Psychophysical Methods (2003)

Sensory and instrumental fabric characteristics that contribute to military clothing comfort are analyzed in a series of studies. A standardized hand evaluation methodology is checked for its sensitivity and reliability and used to characterize thirteen military fabrics. A labeled magnitude scale of comfort is developed using consumer magnitude estimates of the semantic meaning of verbal phrases denoting different levels of comfort/ discomfort. The sensitivity and reliability of this "CALM" scale is assessed in two studies, and the scale is then used by consumers to rate the handle and comfort of the thirteen test fabrics. The descriptive sensory data and comfort data are combined with Kawabata data obtained on a subset of the fabrics, and the data are analyzed with a principal components analysis. Multiple regression analyses are performed using the component scores to predict consumer comfort from the sensory and instrumental data. The results show a high degree of predictability of comfort responses from a combination of sensory and Kawa bata parameters.
Optimization of Scan Time in MRI for Total Hip Prostheses: SEMAC Tailoring for Prosthetic Implants Containing Different Types of Metals (2015)

Five of the most common total hip prostheses have been investigated in vitro. Tailored SEMAC protocols - in terms of scan duration - have been determined. Tailoring was similar for T1-weighted and inversion recovery SEMAC MRI. The suggested prosthesis-related SEMAC adaptation shortens clinical scan times.
GTPase domain of the 54-kD subunit of the mammalian signal recognition particle is required for protein translocation but not for signal sequence binding. (1993)

The 54-kD subunit of the signal recognition particle (SRP54) binds to signal sequences of nascent secretory and transmembrane proteins. SRP54 consists of two separable domains, a 33-kD amino-terminal domain that contains a GTP-binding site (SRP54G) and a 22-kD carboxy-terminal domain (SRP54M) containing binding sites for both the signal sequence and SRP RNA. To examine the function of the two domains in more detail, we have purified SRP54M and used it to assemble a partial SRP that lacks the amino-terminal domain of SRP54 [SRP(-54G)]. This particle recognized signal sequences in two independent assays, albeit less efficiently than intact SRP. Analysis of the signal sequence binding activity of free SRP54 and SRP54M supports the conclusion that SRP54M binds signal sequences with lower affinity than the intact protein. In contrast, when SRP(-54G) was assayed for its ability to promote the translocation of preprolactin across microsomal membranes, it was completely inactive, apparently because it was unable to interact normally with the SRP receptor. These results imply that SRP54G plays an essential role in SRP-mediated targeting of nascent chain-ribosome complexes to the ER membrane and also influences signal sequence recognition, possibly by promoting a tighter association between signal sequences and SRP54M.
Successive conjugate gradient methods for structural analysis with multiple load cases (1994)

Abstract This paper discusses the use of conjugate gradient method for structural engineering analysis with multiple load cases. Specifically, we introduce a modified conjugate gradient method for the solution of a system of linear equations with multiple right‐hand sides. We show how this method can be used to improve the performance of block conjugate gradient method. Numerical results are presented to illustrate the effectiveness of the numerical schemes developed in this study.
Campylobacter pylori gastritis: long term results of treatment with amoxycillin. (1989)

To evaluate the efficacy of amoxycillin in eradicating Campylobacter pylori, endoscopic biopsy specimens were taken from the antral mucosa of 40 children with gastritis before, immediately after, and (in 30 patients) three months after treatment. Immediately after treatment 34 patients (85%) no longer had the organism in the mucosa, and the gastritis had healed in 23 (58%). Three months later the infection had recurred in 22 of 30 patients (73%), and the gastritis had relapsed in all of them. Significantly more children in whom C pylori recurred had family histories of peptic ulcer disease. The results suggest that amoxycillin alone is ineffective in the long term treatment of C pylori gastritis.
Robust Intensity Standardization in Brain Magnetic Resonance Images (2015)

The paper is focused on a tiSsue-Based Standardization Technique (SBST) of magnetic resonance (MR) brain images. Magnetic Resonance Imaging intensities have no fixed tissue-specific numeric meaning, even within the same MRI protocol, for the same body region, or even for images of the same patient obtained on the same scanner in different moments. This affects postprocessing tasks such as automatic segmentation or unsupervised/supervised classification methods, which strictly depend on the observed image intensities, compromising the accuracy and efficiency of many image analyses algorithms. A large number of MR images from public databases, belonging to healthy people and to patients with different degrees of neurodegenerative pathology, were employed together with synthetic MRIs. Combining both histogram and tissue-specific intensity information, a correspondence is obtained for each tissue across images. The novelty consists of computing three standardizing transformations for the three main brain tissues, for each tissue class separately. In order to create a continuous intensity mapping, spline smoothing of the overall slightly discontinuous piecewise-linear intensity transformation is performed. The robustness of the technique is assessed in a post hoc manner, by verifying that automatic segmentation of images before and after standardization gives a high overlapping (Dice index >0.9) for each tissue class, even across images coming from different sources. Furthermore, SBST efficacy is tested by evaluating if and how much it increases intertissue discrimination and by assessing gaussianity of tissue gray-level distributions before and after standardization. Some quantitative comparisons to already existing different approaches available in the literature are performed.
A highly efficient one-flask method for the preparation of the individual diastereoisomers of ribonucleoside 3',5'-cyclic N-substituted phosphoramidates via the direct Appel reaction. X-ray structure of trans-5-isopropyl-2'-deoxyuridine 3',5'-cyclic N-benzylphosphoramidate (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA highly efficient one-flask method for the preparation of the individual diastereoisomers of ribonucleoside 3',5'-cyclic N-substituted phosphoramidates via the direct Appel reaction. X-ray structure of trans-5-isopropyl-2'-deoxyuridine 3',5'-cyclic N-benzylphosphoramidateJozsef Beres, Wesley G. Bentrude, Laszlo Parkanji, Alajos Kalman, and Alan E. SopchikCite this: J. Org. Chem. 1985, 50, 8, 1271–1278Publication Date (Print):April 1, 1985Publication History Published online1 May 2002Published inissue 1 April 1985https://pubs.acs.org/doi/10.1021/jo00208a023https://doi.org/10.1021/jo00208a023research-articleACS PublicationsRequest reuse permissionsArticle Views527Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Single Nucleotide Polymorphism of the Human High Affinity Choline Transporter Alters Transport Rate (2002)

High affinity choline uptake plays a critical role in the regulation of acetylcholine synthesis in cholinergic neurons. Recently, we succeeded in molecular cloning of the high affinity choline transporter (CHT1), which is specifically expressed in cholinergic neurons. Here we demonstrate the presence of functionally relevant, nonsynonymous single nucleotide polymorphism in the human CHT1 gene by comprehensive sequence analysis of the exons and the intron/exon boundaries including the transcription start site. The deduced amino acid change for the polymorphism is isoleucine to valine at amino acid 89 (I89V) located within the third transmembrane domain of the protein. The allele frequency of I89V was 6% for Ashkenazi Jews. Functional assessment of the I89V transporter in mammalian cell lines revealed a 40-50% decrease in V(max) for choline uptake rate compared with the wild type, whereas there was no alteration in the apparent affinities for choline, sodium, chloride, and the specific inhibitor hemicholinum-3. There also was no change in the specific hemicholinum-3 binding activity. The decreased choline uptake was not associated with the surface expression level of the protein as assessed by biotinylation assay. These results suggest an impaired substrate translocation in the I89V transporter. The Caenorhabditis elegans ortholog of CHT1 has a valine residue at the corresponding position and a single replacement from valine to isoleucine caused a decrease in the choline uptake rate by 40%, suggesting that this hydrophobic residue is generally critical in the choline transport rate in CHT1. This polymorphism in the allelic CHT1 gene may represent a predisposing factor for cholinergic dysfunction.
Experimental strategies to improve drug-target identification in mass spectrometry-based thermal stability assays (2023)

Mass spectrometry (MS)-based thermal stability assays have recently emerged as one of the most promising solutions for the identification of protein-ligand interactions. Here, we have investigated eight combinations of several recently introduced MS-based advancements, including the Phase-Constrained Spectral Deconvolution Method, Field Asymmetric Ion Mobility Spectrometry, and the implementation of a carrier sample as improved MS-based acquisition approaches for thermal stability assays (iMAATSA). We used intact Jurkat cells treated with a commercially available MEK inhibitor, followed by heat treatment, to prepare a set of unfractionated isobarically-labeled proof-of-concept samples to compare the performance of eight different iMAATSAs. Finally, the best-performing iMAATSA was compared to a conventional approach and evaluated in a fractionation experiment. Improvements of up to 82% and 86% were demonstrated in protein identifications and high-quality melting curves, respectively, over the conventional approach in the proof-of-concept study, while an approximately 12% improvement in melting curve comparisons was achieved in the fractionation experiment.
Hierarchical Simulation Approaches for the Design of Ultra-Fast Amplifier Circuits (2004)

The silicon-on-insulator (SOI) technology is one of the most promising technologies as the semiconductor industry shifts to 0.13µm and smaller devices. Fully depleted (FD) SOI transistors offer a nearly ideal behavior for application in analog circuits, particularly in high frequency and low power operation. In this work, the design and development of a highly efficient power amplifier circuit is investigated for SOI technology. A fully depleted NMOS SOI transistor is built and characterized, which exhibits TeraHertz cutoff frequencies. The device parameters of this transistor are then extracted to build a compact circuit model for use in the PSPICE circuit simulator. Finally, a low power and high frequency class E power amplifier is designed based on the SOI transistor, and a full analysis of the performance compared to bulk Si technology is performed.
Nonlinearly Coupled in-Plane and Transverse Vibrations of a Spinning Disk (2001)

Abstract Previous nonlinear spinning disk models neglected the in-plane inertia of the disk since this permits the use of a stress function. This paper aims to consider the effect of including the in-plane inertia of the disk on the resulting nonlinear dynamics. The inclusion of the in-plane inertia results in coupling between the in-plane and transverse vibrations of the spinning disk. The full nonlinear equations are simplified to a simpler nonlinear two degrees-of-freedom model via the method of Galerkin. This 2 DOF model is analyzed with a canonical perturbation approach and with numerical simulations. Through the use of these analytical and numerical tools, it becomes apparent that the inclusion of in-plane inertia gives rise to new phenomena in the dynamics of the system that are not predicted if the in-plane inertia is ignored.
Phase II Trial of the CDK4 Inhibitor PD0332991 in Patients With Advanced CDK4 -Amplified Well-Differentiated or Dedifferentiated Liposarcoma (2013)

Treatment with the CDK4 inhibitor PD0332991 was associated with a favorable progression-free rate in patients with CDK4-amplified and RB-expressing WDLS/DDLS who had progressive disease despite systemic therapy.
Effect of fiber orientation on the tensile properties of cross-ply laminates of PP reinforced continuous carbon fiber (2021)

This paper presents an experimental study of tensile properties, using a carbon–polypropylene uni-directional sheet with a thickness of 0.15 mm, which shows that highly non-linear stress–strain curves can be achieved with cross-angle-ply laminates. Generally, these properties are studied from the scanning electronic microscope and X-ray computed tomography. Cross-ply laminates with fiber orientation angles from 15 to 60° are investigated and it is found that there are the pseudo-ductile behavior with the fiber rotation, especially at fiber orientation angles from 30° to 60°.The Pseudo-ductile behavior is a phenomenon in which the apparent strain increases after yielding with strain hardening. It is greatly affected by the fiber reorientation in the loading direction. The fiber reorientation is allowed the plasticity of the polypropylene and thickness of each layer.
DART‐MS as a Preliminary Screening Method for “Herbal Incense”: Chemical Analysis of Synthetic Cannabinoids (2013)

Direct analysis in real time mass spectrometry (DART-MS) served as a method for rapid high-throughput screening of six commercially available "Spice" products, detecting various combinations of five synthetic cannabinoids. Direct analysis in real time is an ambient ionization process that, along with high mass accuracy time-of-flight (TOF)-MS to 0.0001 Da, was employed to establish the presence of cannabinoids. Mass spectra were acquired by simply suspending a small portion of sample between the ion source and the mass spectrometer inlet. The ability to test minute amounts of sample is a major advantage when very limited amounts of evidentiary material are available. In addition, reports are widespread regarding the testing backlogs that now exist because of the large influx of designer drugs. This method circumvents time-consuming sample extraction, derivatization, chromatographic, and other sample preparative steps required for analysis by more conventional mass spectrometric methods. Accordingly, the synthetic cannabinoids AM-2201, JWH-122, JWH-203, JWH-210, and RCS-4 were identified in commercially available herbal Spice products, singly and in tandem, at concentrations within the range of 4-141 mg/g of material. Direct analysis in real time mass spectrometry decreases the time necessary to triage analytical evidence, and therefore, it has the potential to contribute to backlog reduction and more timely criminal prosecution.
The sleep effects of lurasidone: a placebo‐controlled cross‐over study using a 4‐h phase‐advance model of transient insomnia (2016)

Lurasidone had a sleep maintenance effect without effects on sleep onset, rapid eye movement, or slow-wave sleep. Lurasidone is likely to be beneficial to patients with disturbed sleep, particularly those with sleep maintenance problems. Copyright © 2016 John Wiley & Sons, Ltd.
Source-synchronization and timing vernier techniques for 1.2-GB/s SLDRAM interface (1999)

This paper describes a validation system for an SLDRAM interface. The SLDRAM system utilizes two techniques to achieve a high data-transfer rate with a conventional module mounting style. The first technique is a source-synchronization scheme. Since the chip that transmits data also supplies the data clock, the clock and data are completely synchronous. The second is the timing vernier technique. A wait time for output data is programmable in each SLDRAM. Therefore, the time at which data arrive at the controller from any SLDRAM can be set by the controller with a 200-ps step size. The validation chip is designed to emulate these operations. The chip is fabricated using a 0.35-/spl mu/m CMOS process technology and packaged in a conventional 0.65-mm pitch thin small out-line package, mounted on a single-chip module, and put into an eight-module system. A stub series terminated logic (SSTL)-like interface is adopted for high-speed signals. From system-level measurements, the data eye width of 600 ps is obtained at a data rate of 600 Mbps. Errorless data transmission is observed in both read and write operations in a bit-error rate testing. The validation system has successfully demonstrated a data-transmission rate of 1.2 GB/s (600 Mbit/s/pin) using source-synchronization and timing vernier techniques at the supply voltage of 2.5 V.
Herbicidal Metabolites from a Soil-Dwelling Fungus (Scopulariopis brumptii) (1989)

The fungus Scopulariopis brumptii Salvanet-Duval (MSU 42018) was isolated from a soil sample collected from the rhizosphere of a potted asparagus plant. When cultured 7 days in A-9 broth medium, the organism produced compounds phytotoxic to seeding dicotyledonous weeds (via foliar application) and to Chlamydomonas reinhardtii Dangeard. Three herbicidal metabolites, 3-hydroxybenzyl alcohol, 2-methylhydroquinone, and (+)-epiepoformin, were isolated by column and thin-layer chromatography (TLC) and structures confirmed by Fourier transform infrared spectroscopy (FT-IR), nuclear magnetic reasonance spectroscopy (NMR), and mass spectrometry (MS). Of the three compounds, (+)-epiepoformin was the most active, providing complete control of redroot pigweed and 88% control of white mustard when applied at 4.4 kg/ha.
Handling inter-object occlusion for multi-object tracking based on attraction force constraint (2015)

International audience
Comparison of 11C-choline-PET/CT and whole body-MRI for staging of prostate cancer (2007)

Cho-PET/CT and WB-MRI both presented high accuracy in the detection of bone and lymph node metastases. The strength of MRI is excellent image quality providing detailed anatomical information whereas the advantage of Cho-PET/CT is high image contrast of pathological foci.
Boron neutron capture therapy with bevacizumab may prolong the survival of recurrent malignant glioma patients: four cases (2014)

BNCT with the addition of bevacizumab for radiation necrosis or symptomatic pseudoprogression improved the clinical symptoms and prolonged the survival in RMG patients.
Comparison of Rapid-Cycling and Non–Rapid-Cycling Bipolar I Manic Patients During Treatment With Olanzapine (2004)

RC bipolar I patients showed major initial differences and more rapid initial clinical changes, especially toward depression, with less favorable long-term outcomes than non-RC cases during treatment with olanzapine. Inclusion of RC bipolar disorder patients can complicate therapeutic trials, but these patients require further study for differential responsiveness to innovative treatments with methods of assessing clinical response that take their mood instability into account.
Transcriptomic Insights into the Responses in Leaves Storing Lipid Organelles under Different Irradiances (2021)

ABSTRACT To increase the nutritional value of forage, transgenic ryegrass known as H igh M etabolizable E nergy (HME) were previously generated that co-express cysteine-oleosin and diacylglycerol O-acyltransferase. HME not only accumulate lipids in the leaf but also has elevated CO 2 assimilation and increased biomass. Shading is one of the most influencing factors for ryegrass growth environments particularly in swards. The aim of this study, therefore, was to determine the influence of irradiance levels on photosynthesis and gene expression in the HME leaves when compared with their corresponding non-transformant (NT). Under low light (150-250 µmol m -2 s -1 ) and standard light (600-1000 µmol m -2 s -1 ), the HME accumulated more lipid than NT. The previously reported elevated photosynthesis and increased biomass was observed when the HME were grown under standard light but not under low light. Under both light conditions, compared to NT, the HME had upregulated a number of transcripts involved in lipid metabolism, light capturing, photosynthesis, and sugar signalling network while downregulated genes participated in sugar and fructan biosynthesis. We further discuss how the HME differentially manipulated several genes other metabolic pathways including maintenance of redox homeostasis. Combined, the data suggests that the increased photosynthesis capacity in the HME likely corresponds to an increase of micro-lipid sink strength; these are influenced by available light energy and may be related to diffusional and biochemical activities of stomata. Overall, this work provides a clearly understanding of the changes in molecular and biochemical mechanisms underlying the carbon storing as leaf lipid sink of the HME ryegrass. One sentence summary Shading led to increase leaf lipid accumulation but limit the greater photosynthesis trait of high lipid ryegrass which may be related to limitation of biochemical activities of stomata.
Chirped Sub-50 fs Pulse Generation: Optimization of Fiber Length for Ultrafast Fiber Optical Parametric Oscillators (2010)

Sub-50 fs pulses at 940 nm having linear chirp are generated using a synchronously-pumped fiber optical parametric oscillator where the fiber length is chosen to compensate for dispersion from optical components inside of the cavity.