gebhart/patrepeval huggingface dataset:
The UCF/CIRENT Materials Characterization Facility (1998)

Abstract New state-of-the-art analytical equipment is becoming more specialized and more expensive. With the availability of federal funding decreasing over the years, it has become increasingly difficult for University laboratories to maintain and upgrade existing analytical equipment, or purchase new analytical equipment. There are also instances where large industrial laboratories may only need a particular piece of analytical equipment on a part-time basis, or where small companies cannot afford to purchase a particular technique. An obvious solution to these problems is to merge industry and university into a viable working collaboration whereby resources are shared among partners. The University of Central Florida and Cirent Semiconductor (a joint venture of Lucent Technologies and Cirrus Logic) have entered into such a collaboration with the development of the UCF/Cirent Materials Characterization facility (MCF). The MCF is a shared user facility that is available to (i) UCF and other State University System (SUS) Florida University students, faculty, and staff, and (ii) MCF industrial affiliates and others requiring specialized instrumentation and expertise.
MFP scanner diagnostics using a self-printed target to measure the modulation transfer function (2014)

In the current market, reduction of warranty costs is an important avenue for improving profitability by manufacturers of printer products. Our goal is to develop an autonomous capability for diagnosis of printer and scanner caused defects with mid-range laser multifunction printers (MFPs), so as to reduce warranty costs. If the scanner unit of the MFP is not performing according to specification, this issue needs to be diagnosed. If there is a print quality issue, this can be diagnosed by printing a special test page that is resident in the firmware of the MFP unit, and then scanning it. However, the reliability of this process will be compromised if the scanner unit is defective. Thus, for both scanner and printer image quality issues, it is important to be able to properly evaluate the scanner performance. In this paper, we consider evaluation of the scanner performance by measuring its modulation transfer function (MTF). The MTF is a fundamental tool for assessing the performance of imaging systems. Several ways have been proposed to measure the MTF, all of which require a special target, for example a slanted-edge target. It is unacceptably expensive to ship every MFP with such a standard target, and to expect that the customer can keep track of it. To reduce this cost, in this paper, we develop new approach to this task. It is based on a self-printed slanted-edge target. Then, we propose algorithms to improve the results using a self-printed slanted-edge target. Finally, we present experimental results for MTF measurement using self-printed targets and compare them to the results obtained with standard targets.
GABAB receptors suppress burst-firing in reticular thalamic neurons (2017)

Burst-firing in thalamic neurons is known to play a key role in mediating thalamocortical (TC) oscillations that are associated with non-REM sleep and some types of epileptic seizure. Within the TC system the primary output of GABAergic neurons in the reticular thalamic nucleus (RTN) is thought to induce the de-inactivation of T-type calcium channels in thalamic relay (TR) neurons, promoting burst-firing drive to the cortex and the propagation of TC network activity. However, RTN neurons also project back onto other neurons within the RTN. The role of this putative negative feedback upon the RTN itself is less well understood, although is hypothesized to induce de-synchronization of RTN neuron firing leading to the suppression of TC oscillations. Here we tested two hypotheses concerning possible mechanisms underlying TC oscillation modulation. Firstly, we assessed the burst-firing behavior of RTN neurons in response to GABA<sub>B</sub> receptor activation using acute brain slices. The selective GABA<sub>B</sub> receptor agonist baclofen was found to induce suppression of burst-firing concurrent with effects on membrane input resistance. Secondly, RTN neurons express Ca<sub>V</sub>3.2 and Ca<sub>V</sub>3.3 T-type calcium channel isoforms known to contribute toward TC burst-firing and we examined the modulation of these channels by GABA<sub>B</sub> receptor activation. Utilizing exogenously expressed T-type channels we assessed whether GABA<sub>B</sub> receptor activation could directly alter T-type calcium channel properties. Overall, GABA<sub>B</sub> receptor activation had only modest effects on Ca<sub>V</sub>3.2 and Ca<sub>V</sub>3.3 isoforms. The only effect that could be predicted to suppress burst-firing was a hyperpolarized shift in the voltage-dependence of inactivation, potentially causing lower channel availability at membrane potentials critical for burst-firing. Conversely, other effects observed such as a hyperpolarized shift in the voltage-dependence of activation of both Ca<sub>V</sub>3.2 and Ca<sub>V</sub>3.3 as well as increased time constant of activation of the Ca<sub>V</sub>3.3 isoform would be expected to enhance burst-firing. Together, we hypothesize that GABA<sub>B</sub> receptor activation mediates multiple downstream effectors that combined act to suppress burst-firing within the RTN. It appears unlikely that direct GABA<sub>B</sub> receptor-mediated modulation of T-type calcium channels is the major mechanistic contributor to this suppression.
A conceptual modelling approach to authoring-in-the-large for hypertext documents (1991)

article Free Access Share on A conceptual modelling approach to authoring-in-the-large for hypertext documents Authors: Rick Sobiesiak IBM Canada Ltd. Laboratory and University of Toronto IBM Canada Ltd. Laboratory and University of TorontoView Profile , John Mylopoulos University of Toronto University of TorontoView Profile Authors Info & Claims ACM SIGOIS BulletinVolume 12Issue 2-3Nov. 1991 pp 225–239https://doi.org/10.1145/127769.122854Published:01 October 1991Publication History 6citation303DownloadsMetricsTotal Citations6Total Downloads303Last 12 Months23Last 6 weeks6 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Neutrophils degranulate GAG-containing proteoglycofili, which block Shigella growth and degrade virulence factors (2022)

Summary paragraph Neutrophil degranulation plays a central role in their ability to kill pathogens but also to stimulate other immune cells 1–3 . Here we show that neutrophil degranulation, induced in hypoxia or upon Shigella infection in vitro and in vivo , leads to the release of polymers called neutrophil Proteoglycofili (PGF). PGF are mainly composed of granular proteins (myeloperoxidase, elastase, lactoferrin, cathelicidin, albumin) pre-stored in various types of granules, and chondroitin sulfate. PGF individual fibers have a diameter of 43.9 ± 20.3 nm and. They secreted by viable neutrophils and do not contain DNA, as opposed to NETs which contains also granular proteins, chondroitin sulfate in addition to chromatin, released upon neutrophil disintegration and cell death. We demonstrated that PGF block the growth of Shigella and other bacteria and degrade Shigella virulence factors. The degradation of the chondroitin sulfate polymers with testes hyaluronidases destabilizes PGF ultrastructure and abolishes its antimicrobial activity. Our results provide novel insights in the neutrophil degranulation process and open new doors for the investigation of PGF contribution to cytokines concentration gradient formation and adaptive immune cells activation. Further investigations are required to better appreciate the importance of this “sterile blaster” in infectious or inflammatory diseases.
Enzyme electrodes as practical biosensors (1981)

An enzyme can be combined with an electrochemical sensor to produce an electrode that will measure the substrate for that enzyme. Such electrodes, known as enzyme electrodes, have enabled assay of many compounds of biochemical interest. However, they remain largely unexploited in medical measurement. The review gives the basic principles and describes electrodes used in biological solutions, together with an outline of the problems. The development of enzyme electrodes for continuous in vivo monitoring is emphasised.
Tribological properties of diamond-like carbon films deposited by negative carbon ion beam (1998)

Excellent antiwear diamond-like carbon (DLC) films were prepared on silicon wafers by a novel negative carbon ion beam deposition system. This system does not need any gas in the chamber; deposition occurs under high vacuum. The ion source has good control of the C− beam energy (from 50 to 150 eV) and produces a 0.5-in.-diam ion beam for DLC coating. All coatings showed ultrasmooth surfaces (Ra∼1 nm) and good adhesion. The results of infrared and Raman spectroscopy show that the degree of diamond-like character in the films, the sp3 fraction, increases as a function of deposition energy in this particular energy range. The nanoindentation hardness of the films also increases from 15 to 50 GPa as deposition energy increases. The wear rates and friction coefficients against a M-50 steel bearing ball were measured in a pin-on-disk tribometer with a normal load of 9.8 N, calculated nominal Hertzian stress of 0.8–1.8 GPa. The measured wear rates of the DLC films were of the order of 10−7 and 10−8 mm3/N m depending on the deposition energy of the carbon beam. The friction coefficients in the steady state were found to be around 0.1. These results indicate excellent applications for abrasion resistant DLC coatings. We are developing a rectilinear negative carbon ion beam deposition system (up to 8 in.) for large area application, and many of the process scale-up issues have been solved.
Effect of Tannic Acid on Corrosion of Mild Steel in Boiler System (1992)

The effect of tannic acid on the corrosion of mild steel in boiler systems was investigated by physicochemical methods using an autoclave and a test boiler. Tannic acid was found to be a good oxygen scavenger at pH 11 as well as hydrazine and sodium sulphite. Tannic acid inhibited corrosion of steel (i) at room temperature and atmospheric pressure and (ii) at high temperature and pressure. The maximum inhibition efficiency was about 97%. The inhibiting behavior of tannic acid at pH 7 was different from that at pH 11. At pH 7, tannic acid acted as an adsorption-type inhibitor and suppressed catholic reaction of corrosion of steel. At pH 11, tannic acid inhibited corrosion of steel not only as an effective oxygen scavenger but also an effective Schikorr reaction promoter (formation of Fe3O4). Tannic acid is believed to be an effective inhibitor in boiler systems.
Sunken Nose (2021)

A 34-year-old woman presented with rhinorrhea, bloody nasal crusting, and nasal deformity that had progressed over a period of 7 years. Physical examination revealed complete collapse of the nasal bridge and retraction of the tip of the nose, and a diagnosis of granulomatosis with polyangiitis was made.
Anisotropy of the Knoop Hardness in Silicon Nitride Single Crystals and Their Slip System at Room Temperature (1997)

Knoop hardness in α-Si3N4 on the surfaces of (1100), (1120) and (0001) was investigated. Hardness values had isotropic character on all surfaces. Effective resolved shear stress (ERSS) was calculated assuming the slip systems of (0001) ‹1120›, {1100} ‹1120›, {1100} ‹0001›, {1101} ‹1120› and {2201} ‹1120› to be activated. The ERSS curve of the {1101} ‹1120› slip system explains Knoop hardness better than those of other slip systems. This fact supports {1101} ‹1120› to be the primary slip system in α-Si3N4 at room temperature.
[Inhibitory effect of murine cytomegalovirus infection on neural stem cells' differentiation and its mechanisms]. (2006)

These results suggest that MCMV infection could inhibit neuronal differentiation, which may be primary causes of disorders of brain development in congenital CMV infection. The decreased expression of Wnt-1 and Ngn1 may be involved in the inhibitory effect of murine cytomegalovirus infection on neural stem cells' differentiation, which may lead to a new strategy for preventing and treating brain abnormalities caused by CMV infection through regulating these two signal pathways.
A cine K-edge subtraction angiographic system for animal studies (1989)

A cine k-edge subtraction imaging system has been constructed for less invasive transvenous angiography research. It utilizes synchrotron radiation and consists of a monochromator, an x-ray television camera with a high-speed shutter, and a data-acquisition and control unit. A 50×60-mm2 monochromatic x ray of about 400 mR/s intensity is produced. The x-ray photon energy is changed by using an oscillating cam mechanism which changes the angle of the crystal with respect to the beam. 16 ms is required to change the photon energy across the k edge for a change up to 800 eV. K-edge subtraction angiography of rats is performed following intravenous injection of materials containing iodine. Dual-energy images are acquired using 17-ms exposures with the same interval. Repetition of this sequence gives a series of k-edge subtraction images. Arteries of 0.3–0.4 mm diam are clearly seen.
Loss of Asparagine-Linked Glycosylation Sites in Variable Region 5 of Human Immunodeficiency Virus Type 1 Envelope Is Associated with Resistance to CD4 Antibody Ibalizumab (2011)

Ibalizumab (formerly TNX-355) is a first-in-class, monoclonal antibody inhibitor of CD4-mediated human immunodeficiency type 1 (HIV-1) entry. Multiple clinical trials with HIV-infected patients have demonstrated the antiviral activity, safety, and tolerability of ibalizumab treatment. A 9-week phase Ib study adding ibalizumab monotherapy to failing drug regimens led to transient reductions in HIV viral loads and the evolution of HIV-1 variants with reduced susceptibility to ibalizumab. This report characterizes these variants by comparing the phenotypic susceptibilities and envelope (env) sequences of (i) paired baseline and on-treatment virus populations, (ii) individual env clones from selected paired samples, and (iii) env clones containing site-directed mutations. Viruses with reduced susceptibility to ibalizumab were found to exhibit reduced susceptibility to the anti-CD4 antibody RPA-T4. Conversely, susceptibility to soluble CD4, which targets the HIV-1 gp120 envelope protein, was enhanced. No changes in susceptibility to the fusion inhibitor enfuvirtide or the CCR5 antagonist maraviroc were observed. Functionally, viruses with reduced ibalizumab susceptibility also displayed high levels of infectivity relative to those of paired baseline viruses. Individual env clones exhibiting reduced ibalizumab susceptibility contained multiple amino acid changes in different regions relative to the paired baseline clones. In particular, clones with reduced susceptibility to ibalizumab contained fewer potential asparagine-linked glycosylation sites (PNGSs) in variable region 5 (V5) than did paired ibalizumab-susceptible clones. The reduction in ibalizumab susceptibility due to the loss of V5 PNGSs was confirmed by site-directed mutagenesis. Taken together, these findings provide important insights into resistance to this new class of antiretroviral drug.
Termination, Transfer, and Propagation Kinetics of Trimethylaminoethyl Acrylate Chloride Radical Polymerization in Aqueous Solution (2017)

The SP–PLP–EPR (single pulse–pulsed laser polymerization–electron paramagnetic resonance) method has been used to measure the rate coefficients of termination, intramolecular transfer, and propagation for the radical polymerization of 20 wt % trimethylaminoethyl acrylate chloride (TMAEA) in the temperature range 0–90 °C. The high complexity of this acrylate system is due to water being the solvent, to the monomer being a strong electrolyte, and to both secondary chain-end radicals and tertiary midchain radicals being simultaneously present. The termination kinetics, which was analyzed by a chain-length-dependent scheme, largely differs from the situation met with nonionized radicals. The reliability of the rate coefficients obtained from the SP–PLP–EPR experiments has been demonstrated by the almost perfect agreement of TMAEA conversion vs time data from simulation, on the basis of these coefficients, and from the chemically initiated TMAEA polymerization experiment at 70 °C.
Incorporation of a rotavirus vaccine into the national immunisation schedule in the United Kingdom: a review (2013)

This single G1P[8] strain-based human rotavirus vaccine has demonstrated high efficacy in preventing severe rotavirus gastroenteritis in the first 3 years of life in middle- and high-income countries. In countries that have adopted rotavirus vaccine in childhood immunisation programmes, indirect benefits (herd protection) have been observed among older, unvaccinated children and adults. When the first dose is administered between 6 and 14 weeks of age and the last dose by 24 weeks of age, Rotarix carries a small risk of intussusception within the week of vaccination. However, this small risk may at most result in a negligible population attributable risk at the end of the first year of life. Overall, the rotavirus immunisation programme is expected to provide substantial health benefits to the UK population.
Anisotropic nature of high-temperature superconductivity in single-crystalY1Ba2Cu3O7−x (1987)

We report the first contact-free measurements of the upper critical fields, ${\mathrm{H}}_{\mathrm{c}2}$(T), of single-crystal ${\mathrm{Y}}_{1}$${\mathrm{Ba}}_{2}$${\mathrm{Cu}}_{3}$${\mathrm{O}}_{7\mathrm{\ensuremath{-}}\mathrm{x}}$. In contrast to resistive measurements reported by others, we find that the anisotropy near ${\mathrm{T}}_{\mathrm{c}}$ is temperature independent in agreement with the expectations of anisotropic Ginzburg-Landau theory. Estimates of the anisotropic Ginzburg-Landau and London parameters are reported. These indicate that despite the large anisotropy in ${\mathrm{H}}_{\mathrm{c}2}$ (5:1), the inferred low-temperature interplanar coherence length (${\ensuremath{\xi}}_{\mathrm{z}}$=7 A\r{}) remains larger than the Cu-O layer spacing of 3.9 A\r{}. The superconductivity in ${\mathrm{Y}}_{1}$${\mathrm{Ba}}_{2}$${\mathrm{Cu}}_{3}$${\mathrm{O}}_{7\mathrm{\ensuremath{-}}\mathrm{x}}$ thus remains fundamentally three dimensional in nature for a substantial temperature range below ${\mathrm{T}}_{\mathrm{c}}$.
Fiber Optic Communication within the F-35 Mission Systems (2006)

The F-35, joint strike fighter (JSF), aircraft is designed with a highly capable and flexible mission systems architecture. At the heart of this architecture is the integrated core processor (ICP) system that contains a significant portion of the total processing and information sharing required on this next generation fighter aircraft. The processing capabilities contained within the ICP are varied to support diverse sensor and mission processing needs. Providing sufficient communication bandwidth is a key element of this architecture. Fiber optic interfaces are used to provide the necessary bandwidth between the sensors subsystems and the ICP. In addition to the performance benefits of using fiber optic interconnects there other significant benefits including; EMI immunity, scalability, flexibility, protocol independence, and a lower total ownership cost (TOC). The F-35 was conceived and designed as a multi-service multi-role strike fighter. To ensure affordability, the development has focused on the use of open standards and commercial off the shelf (COTS) components when appropriate. When required to develop new technology in support of JSF, first generation products were initially integrated into legacy programs, providing lessons learned for improving the products for the F-35
Transrating Of Mpeg-2 Coded Video Via Requantization With Optimal Trellis-Based Dct Coefficients Modification (2004)

Publication in the conference proceedings of EUSIPCO, Viena, Austria, 2004
Fatty acids as resource of carbon for leptospirae. (1988)

The effect of saturated (palmitic, stearic, myristic) and unsaturated (oleic) fatty acids on the proliferation of Leptospirae was studied. Proliferation of the saprophytic strains G-45, K-1028 (serovar not identified) and of the pathogenic strain VGNKI-3 (serovar canicola) of Leptospirae was obtained on a serum-free medium with the addition of saturated fatty acids. The unsaturated oleic acid at relatively high concentrations (0.5 mg/ml) suppresses proliferation of these spirochetes. It has been demonstrated that the variants used in the experiment can be utilized for the study of nutritional requirements of Leptospirae and their metabolism.
Review on pathophysiology and treatment of diabetic kidney disease. (2010)

Diabetes is the leading cause of chronic kidney disease, which in the Thailand is the most common cause of end stage renal disease (ESRD) requiring dialysis. Patients with diabetic kidney disease (DKD) are at a higher risk of mortality, mostly from cardiovascular complications, than other patients with diabetes. The development of DKD is determined by environmental and genetic factors. This review focuses on the latest published data dealing with mechanisms and treatment of DKD. DKD has several distinct phases of development of the disease and hyperglycemia-induced metabolic and hemodynamic pathways are recognized to be mediators of kidney disease. Multiple biochemical pathways have been postulated that explain how hyperglycemia causes tissue damage: nonenzymatic glycosylation that generates advanced glycosylation end products, activation of protein kinase C, and acceleration of the polyol pathway. Oxidative stress also seems to be a theme common pathway. These derangements, along with hemodynamic changes, activate various cytokines and growth factors such as vascular endothelial growth factor, transforming growth factor-beta2 Interleukin 1 (IL 1), IL-6 and IL-18. Current renoprotective treatments for DKD include optimization of glycemic, blood pressure, lipid and weight control blockade of the renin-angiotensin system, salt and protein restriction. Multiple intensive interventions reduce cardiovascular events as well as nephropathy by about half when compared with a conventional multifactorial treatment.
Controlled creation and displacement of charged domain walls in ferroelectric thin films (2016)

Charged domain walls in ferroelectric materials are of high interest due to their potential use in nanoelectronic devices. While previous approaches have utilized complex scanning probe techniques or frustrative poling here we show the creation of charged domain walls in ferroelectric thin films during simple polarization switching using either a conductive probe tip or patterned top electrodes. We demonstrate that ferroelectric switching is accompanied - without exception - by the appearance of charged domain walls and that these walls can be displaced and erased reliably. We ascertain from a combination of scanning probe microscopy, transmission electron microscopy and phase field simulations that creation of charged domain walls is a by-product of, and as such is always coupled to, ferroelectric switching. This is due to the (110) orientation of the tetragonal (Pb,Sr)TiO3 thin films and the crucial role played by the limited conduction of the LSMO bottom electrode layer used in this study. This work highlights that charged domain walls, far from being exotic, unstable structures, as might have been assumed previously, can be robust, stable easily-controlled features in ferroelectric thin films.