gebhart/patrepeval huggingface dataset:
Design of Time Invariant Analog Front-End Circuits for Deep N-Well CMOS MAPS (2009)

This work is concerned with the design of time invariant analog circuits for processing the signals from deep N-well monolithic CMOS sensors. As compared to the three-transistor front-end typically used in imaging applications, the schemes proposed here, which were conceived to be included in a binary readout channel, lend themselves to pixel-level sparsified readout and are expected to be capable of managing the large flow of data anticipated for the future high luminosity colliding machines while obeying quite severe material budget requirements. Various solutions complying with different power dissipation and point resolution constraints have been implemented in a 130 nm CMOS technology, paying particular attention to equivalent noise charge and threshold dispersion performance. This paper intends to describe and compare the features of the different approaches by means of simulations, experimental results and theoretical analysis.
Semi-Automated Detection of Cerebral Microbleeds on 3.0 T MR Images (2013)

Cerebral microbleeds are associated with vascular disease and dementia. They can be detected on MRI and receive increasing attention. Visual rating is the current standard for microbleed detection, but is rater dependent, has limited reproducibility, modest sensitivity, and can be time-consuming. The goal of the current study is to present a tool for semi-automated detection of microbleeds that can assist human raters in the rating procedure. The radial symmetry transform is originally a technique to highlight circular-shaped objects in two-dimensional images. In the current study, the three-dimensional radial symmetry transform was adapted to detect spherical microbleeds in a series of 72 patients from our hospital, for whom a ground truth visual rating was made by four raters. Potential microbleeds were automatically identified on T2*-weighted 3.0 T MRI scans and the results were visually checked to identify microbleeds. Final ratings of the radial symmetry transform were compared to human ratings. After implementing and optimizing the radial symmetry transform, the method achieved a high sensitivity, while maintaining a modest number of false positives. Depending on the settings, sensitivities ranged from 65%-84% compared to the ground truth rating. Rating of the processed images required 1-2 minutes per participant, in which 20-96 false positive locations per participant were censored. Sensitivities of individual raters ranged from 39%-86% compared to the ground truth and required 5-10 minutes per participant per rater. The sensitivities that were achieved by the radial symmetry transform are similar to those of individual experienced human raters, demonstrating its feasibility and usefulness for semi-automated microbleed detection.
1405Sequential nephron blockade with diuretics improves diastolic dysfunction in patients with resistant hypertension, a substudy a the PHARES trial (2019)

Abstract Introduction Hypertension is one of the major contributors to cardiac diastolic dysfunction as observed in patients with heart failure and preserved ejection fraction. Different therapeutics strategies have been proposed to control blood pressure (BP) but their independent impact on cardiac function remain undetermined. In patients referred to our center for uncontrolled hypertension, we compared changes in cardiac parameters between two strategies consisting of sequential nephron blockade with intensive diuretics (NBD) or sequential renin angiotensin blockade (RAB). Purpose To determine evolution of BNP levels and echocardiographic (TTE) parameters of diastolic dysfunction according to strategies to control BP. Methods After 4-weeks treatment with 300mg irbesartan + 12.5mg hydrochlorothiazide + 5mg amlodipine, 140 patients with uncontrolled hypertension were randomized to either complete nephron blockade with sequential introduction of 25mg spironolactone, 20 to 40mg furosemide and 5mg amiloride (NBD group, n=74) or complete RAAS blockade with 5 to 10mg ramipril and 5 to 10mg bisoprolol (RAB group, n=67). BNP levels and TTE parameters according to ESC guidelines were assessed at baseline and week 12. Results BNP levels were not significantly different in the two groups at baseline (mean±SD 30.1±37.0pg/mL in NBD versus 22.6±22.3pg/mL in RAB, p=0.147) but significantly decreased in NBD at week 12 (20.1±22.7pg/mL in NBD versus 55.2±60.4pg/mL in RAB, p&lt;0.0001). At week 12, only 9 (12%) patients in NBD presented BNP levels &gt;35pg/mL versus 37 (55%) in RAB (p&lt;0.001). Concordantly, TTE parameters such as left ventricular end-diastolic diameter (mean±SD, 49±4mm in NBD and 52±5mm in RAB, p=0,004) and left atrial area (16.9±3.6cm2 in NBD and 19.1±3.7cm2 in RAB, p=0,003) improved significantly in NBD group. The proportions of patients presenting ≥2 criteria of diastolic dysfunction according to ESC guidelines in NBD and RAB group respectively were 31.2% and 19.3% at baseline vs. 3.1% and 32.2% after 12 weeks (p=0.001). In a multivariate analysis, NBD treatment was significantly associated with a decline in BNP levels (p&lt;0.01) even after adjustment on daytime systolic BP lowering, heart rate, renal function, age and gender. Conclusion In patients with uncontrolled hypertension, intensive nephron blockade with sequential addition of diuretics improves markers of diastolic dysfunction independently of BP lowering.
On the Limits of Ellipsoidal Models when Analyzing Dielectric Behavior of Living Cells Emphasis on Red Blood Cells (1999)

The dielectric behavior of red blood cells is simulated by taking into account the real shape (consistent with microscopic observations) and the ellipsoids (prolate and oblate spheroids) having the same surface and volume. We have pointed out that the spectra of the imaginary versus the real part of polarizability, which can be directly derived from the measured data, provide quantitative insight to cell morphology. We emphasize that ellipsoidal approximation is fairly good for random oriented cells, but rather poor whenever oriented cells are measured. This fact is assumed to be the reason for the differences between the reported parameters derived from measurements on single cells and those from observations on (random oriented) cells in suspension.
alpha2delta‐1 Identified as a novel effector underlying the action of brain‐derived neurotrophic factor in hypothalamic control of feeding in mice (641.21) (2014)

Brain‐derived neurotrophic factor (BDNF), a protein that supports neuronal survival and synaptic plasticity, is essential for energy balance regulation. Genetic polymorphisms that impede BDNF function pose risk factors for obesity in humans. Similarly, blunted BDNF signaling in the rodent brain is associated with overeating (OV), body weight (BW) gain and metabolic dysfunction. Here we identified alpha2delta‐1 (α2δ‐1), a high voltage‐gated calcium channel subunit and thrombospondin receptor, as a novel appetite regulator underlying BDNF function in the ventromedial hypothalamus (VMH). α2δ‐1 is highly expressed in the VMH of wild‐type (WT) mice. Moreover, mice lacking central Bdnf (CM) have reduced cell surface α2δ‐1 expression in VMH cells. Selective inhibition of VMH α2δ‐1 in WT mice through chronic delivery of gabapentin resulted in a significant increase in food intake and BW gain after 7 days. Rescuing the α2δ‐1 deficit in VMH cells of CM, through targeted delivery of an adeno‐associated virus encoding α2δ‐1, mitigated the OV and BW gain and normalized glucose homeostasis. These data inform mechanisms underlying effects of BDNF in the VMH and identify a critical role for α2δ‐1 in feeding control.
Enabling Smart Navigation by Incorporating Human Inspired Evaluation of Route Sections (2018)

It is challenging for every child not becoming lost in the shopping center. Simulated agents have the same problem. So they need some localization. On the basis of the existing cognitive architecture in th project Simulation of Mental Apparatus and Applications (SiMA) at the Institute of Computer Technology (ICT) currently, we show, how cognitive architectures can get extended by location awareness and navigation in a human-like way. This paper deals with particular requirements for the used data structures to enable self-localization and pathfinding in a bionically inspired way. The typical data structure for navigation in the form of a connected graph gets modified and extended to be compatible with psychoanalytic concepts and still allow navigation. The functionality was implemented exemplary in a multiagent simulation.
Intravascular lymphoma - The creepy crawler: A case series and brief literature review (2021)

We present four cases of intravascular large B-cell lymphoma (IVLBCL), a rare malignancy with poor outcomes. The exclusive presence of lymphoma cells in blood vessels leads to a heterogenous presentation and poor diagnostic yield with traditional initial diagnostic tools. Timely diagnosis and treatment can lead to improved outcomes.
Precise performance analysis of MRC diversity in micro-cellular systems with cochannel interference (2005)

The outage and BER analysis of maximal ratio combining for bandlimited BPSK systems in microcellular system with cochannel interference is considered. A Nakagami/Rayleigh fading model is assumed. Spectrum raised-cosine and Beaulieu-Tan-Damen pulse shapes are employed. Exact closed-form expressions for outage probability with equal and distinct interferers powers are derived. An average bit error rate expression is derived using Gaussian approximation of the cochannel interference. Monte-Carlo simulation is used to validate the Gaussian approximation. The results are valid for arbitrary diversity order and desired user fading parameter. Slow flat fading, asynchronous timing and independent fading gains are assumed.
Xenopsin: the neurotensin-like octapeptide from Xenopus skin at the carboxyl terminus of its precursor. (1984)

We have synthesized two oligodeoxyribonucleotide mixtures that contain sequences complementary to different parts of the hypothetical mRNA sequence of xenopsin, a biologically active octapeptide found in skin extracts from Xenopus laevis. The two primer pools were independently used to initiate reverse transcription on skin poly(A)+ RNA and the resulting cDNAs were then used to screen in parallel a cDNA library prepared from skin poly(A)+ RNA. One of the clones that hybridized with both probes was subjected to sequence analysis. It contains a nearly full-length DNA copy of a mRNA of approximately equal to 490 nucleotides that encodes a xenopsin precursor protein. The deduced precursor is 80 amino acids long, exhibits a putative signal sequence at the NH2 terminus, and contains the biologically active peptide at the COOH terminus. The region corresponding to the NH2-terminal portion of the xenopsin precursor shows a striking nucleotide and amino acid sequence homology with the precursor of PYLa, another recently described peptide from Xenopus skin.
A high-performance UV/visible photodetector of Cu2O/ZnO hybrid nanofilms on SWNT-based flexible conducting substrates (2014)

A Cu<sub>2</sub>O/ZnO nanofilm photodetector was fabricated on flexible SWNT-coated substrates, which demonstrates excellent responsiveness under UV/visible illumination without external bias.
Calcium as a nonradiative recombination center in InGaN (2017)

Calcium can be unintentionally incorporated during the growth of semiconductor devices. Using hybrid functional first-principles calculations, we assess the role of Ca impurities in GaN. Ca substituted on the cation site acts as a deep acceptor with a level ~1 eV above the GaN valence-band maximum. We find that for Ca concentrations of 1017 cm−3, the Shockley–Read–Hall recombination coefficient, A, of InGaN exceeds 106 s−1 for band gaps less than 2.5 eV. A values of this magnitude can lead to significant reductions in the efficiency of light-emitting diodes.
Thermoelectric properties on n-type Si80Ge20 with different Dopants (2006)

Si <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> Ge <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1-x</sub> is typical thermoelectric materials used for higher temperature as thermoelectric generator. Their property is dependent on their composition. Here different dopants, including P, Ga, B, GaP, In, Sb and InSb, were used to investigate their effect on the thermoelectric properties of n type Si <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">80</sub> Ge <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">20</sub> alloys. The results describe that GaP and InSb are good dopant for n type alloys. Especially p type dopants Ga and In are very good multiplex dopant as dopants GaP and InSb for n type Si <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">80</sub> Ge <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">20</sub> respectively by Seebeck coefficient of n type Si <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">80</sub> Ge <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">20 </sub> at same time
Synthesis and structure of FeCl(C.tplbond.CPh)(DMPE)2 (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and structure of FeCl(C.tplbond.CPh)(DMPE)2Leslie D. Field, Adrian V. George, and Trevor W. HambleyCite this: Inorg. Chem. 1990, 29, 22, 4565–4569Publication Date (Print):October 1, 1990Publication History Published online1 May 2002Published inissue 1 October 1990https://pubs.acs.org/doi/10.1021/ic00347a046https://doi.org/10.1021/ic00347a046research-articleACS PublicationsRequest reuse permissionsArticle Views171Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Ligation-anchored PCR: A simple amplification technique with single-sided specificity (1993)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Supragingival Plaque May Modify the Effects of Subgingival Bacteria on Attachment Loss (2006)

This study suggests that the association of certain subgingival microorganisms with CAL changes in relation to supragingival plaque levels in older adult women. It also suggests that the overall effect of dental plaque is a function of the balance between pathogenic and other microorganisms that colonize this environment. Therefore, all microorganisms in the biofilm, including those with no apparent association with overt disease and those with negative associations, may play roles in the pathogenesis of periodontal diseases.
Wake Vortex Profiling by Doppler X-band radar : Orly trials at Initial Take-Off &#x00026; ILS interception critical areas (2008)

In order to improve the capacity of airports in view of the expected increasing amount of traffic the knowledge about the safety issues caused by wake vortices has to be improved. The final goal is to build up a wake vortex alert system to ensure the application of appropriate but not oversized safety distances in all weather conditions. Lidar systems are able to deliver very accurate data, but are also sensitive to the weather conditions like rain and fog. We did trials with the X-band radar BOR-A 550 on Orly Airport in November, 2006 at initial take-off and in October 2007 at ILS interception area. Continuous detection, characterization (strength : circulation), and profiling (age : young/mature/old/decaying) capabilities of wake vortices up to a range of 700 m have been proved in clear air and rainy weather. Opportunity detection of wake vortex was also obtained at long range until 7 Km in clear air. The Doppler resolution of around 0.2 m/s used with regularized high Doppler resolution techniques is able to characterize the wake vortex speed distribution in detail. X-band radar is a full-fledged alternative, which can make a significant contribution to a wake vortex alert system.
Simple Pointspread Retinoscope Suitable for Vision Screening (1987)

A simple pointspread retinoscope and method of retinoscopy are described which use optical principles similar to those of photoretinoscopy or static photographic skiascopy. In this instrument the degree of defocus of an eye is estimated from the disappearance of the bright fundal reflex or "crescent" in the eye of the subject when the distance between the light source and the eye of the observer is increased systematically. The instrument is particularly suitable for large scale screening efforts because it is easy to use and can be constructed from inexpensive materials. The pointspread retinoscope was calibrated against an artificial eye of known defocus. Additionally, results from pointspread retinoscopy were compared against meridional photorefractive data from a sample of infants and young children, and a significant correlation was found to exist between measurements made by the two methods.
Short-term, within-person variability in clinical chemistry test results. Experience from the Atherosclerosis Risk in Communities Study. (1994)

We report the within-person, between-person, and methodological variances of a number of chemical analytes for free-living, middle-aged adults who participated in the Atherosclerosis Risk in Communities Study's Intraindividual Variability Study. The Atherosclerosis Risk in Communities Study is a National Institutes of Health-sponsored multicenter study of atherosclerotic risk factors. In the Atherosclerosis Risk in Communities Study and its Intraindividual Variability Study, concentrations of the following 12 chemical analytes were measured in serum from fasting individuals: sodium, calcium, potassium, creatinine, albumin, total protein, magnesium, phosphorus, urea, insulin, glucose, and urate. The analytes are listed in order of the increasing reliability coefficient (ie, the fraction that between-person variance represents of the total observed population variance), which ranged from .59 for sodium to .91 for urate. The reliability coefficient is a strong predictor of the possibility of finding statistical correlations between measured analyte concentrations and disease occurrence in an epidemiological study like the Atherosclerosis Risk in Communities Study. The within-person variance and methodological variance are also useful in computing confidence intervals for sequential laboratory test results in patients and evaluating limits for internal quality control and proficiency testing programs.
A Training Tool for MMIC Designers (1994)

A framework program MADE (MMIC Automated Design Environment) (figure 1) is presented which is used in the training of undergraduate and postgraduate engineering students for the design and layout of MMIC circuits. The expert system submodules of MADE; ADAM, GALEDA and GALA are described. Starting from a performance specification, the user is advised on microwave circuit topology selection, design of custom and standard cells including foundry specific parasitics and optimum layout to minimise real estate usage and avoid Intercomponent coupling.
M3D-VTON: A Monocular-to-3D Virtual Try-On Network (2021)

Virtual 3D try-on can provide an intuitive and realistic view for online shopping and has a huge potential commercial value. However, existing 3D virtual try-on methods mainly rely on annotated 3D human shapes and garment templates, which hinders their applications in practical scenarios. 2D virtual try-on approaches provide a faster alternative to manipulate clothed humans, but lack the rich and realistic 3D representation. In this paper, we propose a novel Monocular-to-3D Virtual Try-On Network (M3D-VTON) that builds on the merits of both 2D and 3D approaches. By integrating 2D information efficiently and learning a mapping that lifts the 2D representation to 3D, we make the first attempt to reconstruct a 3D try-on mesh only taking the target clothing and a person image as inputs. The proposed M3D-VTON includes three modules: 1) The Monocular Prediction Module (MPM) that estimates an initial full-body depth map and accomplishes 2D clothes-person alignment through a novel two-stage warping procedure; 2) The Depth Refinement Module (DRM) that refines the initial body depth to produce more detailed pleat and face characteristics; 3) The Texture Fusion Module (TFM) that fuses the warped clothing with the non-target body part to refine the results. We also construct a high-quality synthesized Monocular-to-3D virtual try-on dataset, in which each person image is associated with a front and a back depth map. Extensive experiments demonstrate that the proposed M3D-VTON can manipulate and reconstruct the 3D human body wearing the given clothing with compelling details and is more efficient than other 3D approaches. <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup>
Intramolecular Aldol Condensation Route to 14α,17α-Propanoestradiols and 14α,17α-Ethano-17a-homoestradiols (1994)

17β-Acetoxy-3-methoxy-20-oxo-19-nor-17α-pregna-1,3, 5(10)-triene-14-carbaldehyde undergoes intramolecular aldol condensation to give 14α,17α-bridged intermediates which are converted into 14α,17α-propano and 14α,17α-ethano-17a-homo analogues of estradiol.
Application-Layer Multicast Extensions to REsource LOcation And Discovery (RELOAD) (2013)

We define a REsource LOcation And Discovery (RELOAD) Usage for Application-Layer Multicast (ALM) as well as a mapping to the RELOAD experimental message type to support ALM.The ALM Usage is intended to support a variety of ALM control algorithms in an overlayindependent way.Two example algorithms are defined, based on Scribe and P2PCast.
Amino Derivatives of Indole As Potent Inhibitors of Isoprenylcysteine Carboxyl Methyltransferase (2010)

The enzyme isoprenylcysteine carboxyl methyltransferase (Icmt) plays an important role in the post-translational modification of proteins that are involved in the regulation of cell growth. The indole acetamide cysmethynil is by far the most potent and widely investigated Icmt inhibitor, but it has modest antiproliferative activity and may have pharmacokinetic limitations due to its lipophilic character. We report here that cysmethynil can be structurally modified to give analogues that are as potent in inhibiting Icmt but with significantly greater antiproliferative activity. Key modifications were the replacement of the acetamide side chain by tertiary amino groups, the n-octyl side chain by isoprenyl and the 5-m-tolyl ring by fluorine. Moreover, these analogues have lower lipophilicities that could lead to improved pharmacokinetic profiles.