gebhart/patrepeval huggingface dataset:
The fou2 Gain-of-Function Allele and the Wild-Type Allele of Two Pore Channel 1 Contribute to Different Extents or by Different Mechanisms to Defense Gene Expression in Arabidopsis (2007)

The fatty acid oxygenation up-regulated 2 (fou2) mutant in Arabidopsis thaliana creates a gain-of-function allele in a non-selective cation channel encoded by the Two Pore Channel 1 (TPC1) gene. This mutant genetically implicates cation fluxes in the control of the positive feedback loop whereby jasmonic acid (JA) stimulates its own synthesis. In this study we observed extensive transcriptome reprogramming in healthy fou2 leaves closely resembling that induced by treatment with methyl jasmonate, biotic stresses and the potassium starvation response. Proteomic analysis of fou2 leaves identified increased levels of seven biotic stress- and JA-inducible proteins. In agreement with these analyses, epistasis studies performed by crossing fou2 with aos indicated that elevated levels of JA in fou2 are the major determinant of the mutant phenotype. In addition, generation of fou2 aba1-5, fou2 etr1-1 and fou2 npr1-1 double mutants showed that the fou2 phenotype was only weakly affected by ABA levels and unaffected by mutations in NPR1 and ETR1. The results now suggest possible mechanisms whereby fou2 could induce JA synthesis/signaling early in the wound response. In contrast to fou2, transcriptome analysis of a loss-of-function allele of TPC1, tpc1-2, revealed no differential expression of JA biosynthesis genes in resting leaves. However, the analysis disclosed reduced mRNA levels of the pathogenesis-related genes PDF1.2a and THI2.1 in healthy and diseased tpc1-2 leaves. The results suggest that wild-type TPC1 contributes to their expression by mechanisms somewhat different from those affecting their expression in fou2.
ChemInform Abstract: 2‐Arylsubstituted Benzo‐Annelated Five‐Ring Heterocycles and Potential Active Agents in the Cardiovascular System. Part 1. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Semi-Automatic Shape Extraction from Tube-like Geometry (2000)

Although the principle of using x-rays for diagnostic imaging has been known for a long time, there is still a lot of research and improvements going on in the field. One recent addition to the neuro-vascular imaging system—used for visualizing blood vessels in the brain and guidance of interventions—is 3D rotational angiography (3D-RA). Using 3D-RA, it is possible to view the vessel tree in 3D. Traditionally, 3D information could only be obtained with dedicated tube-shaped MR and CT scanners that are not available in the intervention room. With 3DRA, the 3D images can be generated in the intervention room, without moving the patient to and from the CT scanner. Also, the spatial resolution is better than that of MR and CT scanners.
Supplementary Data from ASO-Based PKM Splice-Switching Therapy Inhibits Hepatocellular Carcinoma Growth (2023)

Supplementary Data from ASO-Based PKM Splice-Switching Therapy Inhibits Hepatocellular Carcinoma Growth
Índice Hemodinâmico Agudo Prediz Mortalidade Intra-Hospitalar de Pacientes com Insuficiência Cardíaca Aguda Descompensada (2021)

The AHI independently predicts in-hospital mortality in acute decompensated HF. This simple bed-side index could be useful in an emergency setting. (Arq Bras Cardiol. 2021; 116(1):77-86).
Alcohol (2001)

Intakes of nutrients by individuals are customarily described with broad areas of acceptable choice between some average lower limit of needed supply and an average safe upper limit. Safe upper limits of average alcohol consumption by individuals have been a principal focus of national dialog for 200 yr. The Dietary Guidelines for Americans (1) recommend no more than 1 drink/d for women or 2 drinks/d for men (with a standard drink being either 12 oz regular beer, 5 oz wine, or 1.5 oz distilled spirits, each containing about 14 g [100 calories] of ethanol). At this time, no major scientific body recognizes a nutritional need for alcohol, or recommends that those who do not drink should begin doing so.
Permeability and Conductivity of Red Blood Cell Templated Polyelectrolyte Capsules Coated with Supplementary Layers (2004)

The permeability of ions and small polar molecules through polyelectrolyte multilayer capsules templated on red blood cells was studied by means of confocal microscopy and electrorotation. Capsules were obtained by removing the cell after polyelectrolyte multilayer formation by means of NaOCl treatment. This procedure results in cross-linking of poly(allylamine hydrochloride) (PAH) molecules and destroying poly(styrene sulfonate) (PSS) within the multilayer. Capsules are obtained being remarkably different from layer-by-layer (LbL) capsules. These capsules are rather permeable for low as well as for high molecular weight species. However, upon adsorption of extra polyelectrolyte layers the permeability decreased remarkably. The assembly of six supplementary layers of PAH and PSS rendered the capsule almost impermeable for fluorescein. Resealing by supplementary layers is a potential means for filling and release control. By means of electrorotation measurements, it was shown that the capsule walls obtained isolating properties in electrolyte solutions. Conclusions are drawn concerning the mechanism of permeability through cell templated polyelectrolyte multilayer capsules.
Animating human locomotion with inverse dynamics (1996)

Because the major force components (the internal muscular forces and torques) are not known a priori over time, you cannot use forward dynamics to predict how the human body will walk. The alternative to the apparently intractable problem of specifying the joint torque patterns in advance is to use inverse dynamics to analyze the torques and forces required for the given motion. Such an analysis can show, for example, that the motion induces excessive torque, that the system is out of balance at a certain point, or that the step length is too great. We present a method of using an inverse dynamics computation to dynamically balance the resulting walking motion and to maintain the joint torques within a moderate range imposed by human strength limits. This method corrects or predicts a motion as indicated by the inverse dynamics analysis. Dynamic correctness is a sufficient condition for realistic motion of nonliving objects. In animating a self-actuated system, however, visual realism is another important, separate criterion for determining the success of a technique. Dynamic correctness is not a sufficient condition for this visual realism. An animation of dynamically balanced walking that is also comfortable in the sense of avoiding strength violations can still look quite different from normal human walking. A visually realistic and dynamically sound animation of human locomotion is obtained using an effective combination of kinematic and dynamic techniques.
Random Copolycarbonates: Characterization and Comparative Properties of Polymers Containing Tetrachlorinated Bisphenols (1974)

Several 2,2',6,6'-tetrachloro-4,4'-dihydroxy bisphenols were subjected to random copolymerization with bisphenol A at two levels of incorporation. Copolymerization of TCBF with isomeric chlorinated bisphenols was also carried out. Original, as well as aged physicals, were obtained for all of the copolycarbonates except TCBF. The most interesting properties were obtained from copolymers of TCBF under the conditions studied. Copolymers containing TCBF possessed properties that in general were equal to or better than either bisphenol A or tetra-chlorobisphenol A homopolycarbonates, e.g., the bisphenol A copolymer containing 70% TCBF was found to have a Tg of 190°C. This latter copolycarbonate, as well as that prepared from TCBF and a mixture of chlorinated isomers had significantly better stress cracking resistance to perchlorinated hydrocarbon solvents than either bisphenol A or tetrachlorobisphenol A homopolymers.
Efficacy of long term cyclic administration of the poorly absorbed antibiotic Rifaximin in symptomatic, uncomplicated colonic diverticular disease (2007)

In patients with symptomatic, uncomplicated diverticular disease, cyclic administration of Rifaximin plus dietary fiber supplementation is more effective in reducing both symptom and complication frequency than simple dietary fiber supplementation. Long term administration of the poorly absorbed antibiotic Rifaximin is safe and well tolerated by the patients, confirming the usefulness of this therapeutic strategy in the overall management of diverticular disease.
Driven Downtown: Tight Coupling of GPS, Laser Scanner, and Inertial Measurements (2008)

This article describes an integrated multisensor approach to navigation technology that combines complementary features from different navigation technologies. The result is accurate and reliable navigation capabilities for urban scenarios. In the article, the author takes earlier developments in the fields of inertial navigation system (INS)/laser scanner and Global Positioning System (GPS) laser scanner integration. These efforts are then extended by combining GPS, laser scanner, and inertial data into a single multisensor integrated solution. Potential applications for the described technique can be found in the guidance and control of autonomous ground and aerial vehicles.
Der Sinn der »Wertfreiheit« der soziologischen und ökonomischen Wissenschaften (2000)

Partindo do filme do cineasta alemao Wim Wenders, O fim da violencia, este artigo procura problematizar o nascimento de novas formas de controle societario, analisando suas implicacoes, como a producao de novas subjetividades. Essas formas de controle sao intensificadas pela utilizacao das hodiernas tecnologias do virtual, tao importantes para o desenvolvimento do capitalismo pos-industrial.
Toll‐like receptor 9, maternal cell‐free DNA and myometrial cell response to CpG oligodeoxynucleotide stimulation (2019)

Myometrial and decidual TLR9 are unlikely to directly regulate human parturition.
Mesenchymal stem cells and tumor (2013)

Mesenchymal stem cells(MSCs),with a high degree of self-renewal and differentiation potential and well organized migration and tumor targeting,are from the mesoderm and are a class of non-hematopoietic stem cells.Extensive research has been carried out in the anti-tumor therapy of MSCs.MSCs can be used as a cell vehicle to resist tumots,meanwhile MSCs can promote malignant behavior of tumor by promoting tumor angiogenesis,immunesuppression and differentiating to tumor-associated fibroblasts.This article is a brief overview of the research progress in recent years in the field.
Age-Specific Diastolic Dysfunction Improves Prediction of Symptomatic Heart Failure by Stage B Heart Failure (2019)

Age-specific ARIC DD criteria, but not ASE/EACVI DD criteria, predicted symptomatic HF, and addition of age-specific ARIC DD criteria to ARIC SBHF criteria improved prediction of symptomatic HF in asymptomatic individuals with cardiovascular disease risk factors. Addition of LS to ASE/EACVI or ARIC SBHF criteria did not improve prediction of symptomatic HF.
Biological Chemistry of Naturally Occurring Thiols of Microbial and Marine Origin (2005)

The presence of thiols in living systems is critical for the maintenance of cellular redox potentials and protein thiol-disulfide ratios, as well as for the protection of cells from reactive oxygen species. In addition to the well-studied tripeptide glutathione (gamma-Glu-Cys-Gly), a number of compounds have been identified that contribute to these essential cellular roles. This review provides a survey of the chemistry and biochemistry of several critically important and naturally occurring intracellular thiols such as coenzyme M, trypanothione, mycothiol, ergothioneine, and the ovothiols. Coenzyme M is a key thiol required for methane production in methogenic bacteria. Trypanothione and mycothiol are very important to the biochemistry of a number of human pathogens, and the enzymes utilizing these thiols have been recognized as important novel drug targets. Ergothioneine, although synthesized by fungi and the Actinomycetales bacteria, is present at significant physiological levels in humans and may contribute to single electron redox reactions in cells. The ovothiols appear to function as important modulators of reactive oxygen toxicity and appear to serve as small molecule mimics of glutathione peroxidase, a key enzyme in the detoxification of reactive oxygen species.
Hydrothermal synthesis, structure and catalytic property of a novel openframework oxovanadium arsenate (2001)

A three-dimensional oxovanadium arsenate has been hydrothermally synthesized and structurally determined, which is composed of novel decavanadium clusters linked by AsO4 tetrahedra to form large cavities with 12-membered ring windows; catalytic measurements show activity for phenol hydroxylation.
Research and Discovery Science and the Future of Dental Education and Practice (2017)

Dental graduates of 2040 will face new and complex challenges. If they are to meet these challenges, dental schools must develop a research and discovery mission that will equip graduates with the new knowledge required to function in a modern health care environment. The dental practitioner of 2040 will place greater emphasis on risk assessment, disease prevention, and health maintenance; and the emerging discipline of precision medicine and systems biology will revolutionize disease diagnosis and reveal new targeted therapies. The dental graduate of 2040 will be expected to function effectively in a collaborative, learning health care system and to understand the impact of health care policy on local, national, and global communities. Emerging scientific fields such as big data analytics, stem cell biology, tissue engineering, and advanced biomimetics will impact dental practice. Despite all the warning signs indicating how the changing scientific and heath care landscape will dramatically alter dental education and dental practice, dental schools have yet to reconsider their research and educational priorities and clinical practice objectives. Until dental schools and the practicing community come to grips with these challenges, this persistent attitude of complacency will likely be at the dental profession's peril. This article was written as part of the project "Advancing Dental Education in the 21<sup>st</sup> Century."
Early changes in protein synthesis induced by basic fibroblast growth factor, nerve growth factor, and epidermal growth factor in PC12 pheochromocytoma cells. (1994)

Nerve growth factor (NGF) and basic fibroblast growth factor (bFGF) stimulate neuronal differentiation, whereas epidermal growth factor (EGF) promotes only mitogenic responses in PC12 pheochromocytoma cells. The early changes in protein synthesis induced by bFGF, NGF, and EGF in these cells have been determined by two-dimensional PAGE of [35S]methionine-labeled proteins and computerized image analysis. The rate of synthesis of only 29 proteins (out of approximately 1500 identified) was found to be modulated during the first several hours of growth factor stimulation. Individually, 12 were affected by EGF, 23 were affected by bFGF, and 20 were affected by NGF. Eight of these were regulated by all three growth factors, while 10 proteins were commonly induced by bFGF and NGF, in accordance with the essentially identical morphological responses induced by these two factors. In addition, the effects of bFGF and NGF were about equally divided between increases and decreases in the rate of synthesis of individual proteins, whereas EGF caused significantly more positive (increased) responses. All proteins modulated by NGF or FGF alone were negative in their response and those induced by only EGF were positive. Of particular interest, the rate of synthesis of two proteins of 55 kDa and pI 5.45 and 5.50 was dramatically and transiently induced during the first 2 hr of bFGF and NGF treatment and was not affected by EGF. This study indicates that all three factors elicit early increases and decreases in the synthesis of a quite limited number of proteins and provides molecular evidence for the specificity of a differentiative vs. a proliferative growth factor-induced signaling pathway in these cells.
Cadherin-6 is a putative tumor suppressor and target of epigenetically dysregulated miR-429 in cholangiocarcinoma (2016)

Cholangiocarcinoma (CC) is a rare malignancy of the extrahepatic or intrahepatic biliary tract with an outstanding poor prognosis. Non-surgical therapeutic regimens result in minimally improved survival of CC patients. Global genomic analyses identified a few recurrently mutated genes, some of them in genes involved in epigenetic patterning. In a previous study, we demonstrated global DNA methylation changes in CC, indicating major contribution of epigenetic alterations to cholangiocarcinogenesis. Here, we aimed at the identification and characterization of CC-related, differentially methylated regions (DMRs) in potential microRNA promoters and of genes targeted by identified microRNAs. Twenty-seven hypermethylated and 13 hypomethylated potential promoter regions of microRNAs, known to be associated with cancer-related pathways like Wnt, ErbB, and PI3K-Akt signaling, were identified. Selected DMRs were confirmed in 2 independent patient cohorts. Inverse correlation between promoter methylation and expression suggested miR-129-2 and members of the miR-200 family (miR-200a, miR-200b, and miR-429) as novel tumor suppressors and oncomiRs, respectively, in CC. Tumor suppressor genes deleted in liver cancer 1 (DLC1), F-box/WD-repeat-containing protein 7 (FBXW7), and cadherin-6 (CDH6) were identified as presumed targets in CC. Tissue microarrays of a representative and well-characterized cohort of biliary tract cancers (n=212) displayed stepwise downregulation of CDH6 and association with poor patient outcome. Ectopic expression of CDH6 on the other hand, delayed growth in the CC cell lines EGI-1 and TFK-1, together suggesting a tumor suppressive function of CDH6. Our work represents a valuable repository for the study of epigenetically altered miRNAs in cholangiocarcinogenesis and novel putative, CC-related tumor suppressive miRNAs and oncomiRs.
Neuromyelitis Optica: A New Perspective (2008)

The traditional view of neuromyelitis optica (NMO) as a monophasic inflammatory disorder that affects both the optic nerves and the spinal cord is expanding. Over the last decade, a combination of clinical, radiological, pathological, and serological findings have resulted in evolving definitions of NMO and the appreciation that it likely constitutes a broader, more diverse spectrum of disease that is pathogenically distinct from multiple sclerosis. Neuromyelitis optica-immunoglobulin (Ig)G is the first antibody marker for any inflammatory central nervous system disorder, and is both sensitive and specific for NMO. Its target antigen, aquaporin-4, the most abundant water channel in the central nervous system, has opened up new research directions into demyelinating disorders of the central nervous system. The identification of NMO-IgG in patients with recurrent optic neuritis or longitudinally extensive myelitis and its ability to predict subsequent relapse support the concept of a spectrum of NMO disorders. Preliminary in vitro studies and recent immunopathological evidence support a role for NMO-IgG as the initiator of the NMO lesion. Definitive proof of pathogenesis is needed and will require the development of active immunization and passive transfer animal models, which will hopefully lead to more effective targeted therapies.
New synthesis of 4,5-diaryl-1,3-oxathiol-2-ones (2004)

A new method for the synthesis of 4,5-diaryl-1,3-oxathiol-2-ones by the reaction of 2-hydroxyethanone derivatives with 1,1’-thiocarbonyldiimidazole is proposed. The structure of 4,5-bis(4-methoxyphenyl)-1,3-oxathiol-2-one was studied by X-ray diffraction.
Intracellular Metabolism of β-L-ddAMP-bis(tbutylSATE), a Potent Inhibitor of Hepatitis B Virus Replication (1999)

beta-L-ddAMP-bis(tbutylSATE) is a potent inhibitor of HBV replication with an EC50 = 0.1 microM. Following a 0- to 72-hrs exposure of human hepatocytes to a 10 microM [2',3'-3H] beta-L-ddAMP-bis(tbutylSATE), the pharmacologically active beta-L-ddATP was the predominant metabolite attaining a concentration of 268.53 +/- 107.97 pmoles/10(6) cells at 2 hrs. In Hep-G2 cell, beta-L-ddATP accounted for 146.8 +/- 29.8 pmoles/10(6) cells at 2 hrs with an half life of approximately 5.4 hrs. This study reveals that extensive intracellular concentrations of beta-L-ddATP after incubation of cells to the parent drug is accounting for its potent antiviral activity.
A novel SVM approach of islanding detection in micro grid (2012)

Passive islanding detection schemes are more used in utilities due to their low costs and less harmonic problems although having larger Non Detection Zones (NDZ) relative to other schemes. Passive system measurements at the point of common coupling (PCC) are the basis of this scheme. A new approach in passive techniques is the use of intelligent based methods in data-mining to classify the system parameters which affect the islanding detection. As a result, by finding an efficient and robust data-mining algorithm, the passive schemes problem, which is their relatively large NDZ, will be minimized. In this paper, massive measurements are collected by simulation of IEEE standard distribution system in PSCAD/EMTP environment. These indices include current, voltage, frequency, active power and frequency over active power. The classifying process of these indices is done by the Support Vector Machine (SVM) using MATLAB software. The results show the efficiency with good speed of SVM in passive islanding detection schemes. Also, this paper studies the best two indices which can be used for islanding detection. SVM technique can be easily implemented in the Micro Grid with different types and penetration levels of Distributed Generation (DG).
Characterization of insulators for electric insulation in vacuum (2002)

Flashover has been demonstrated to find its origin in the relaxation of the energy that is stored during insulator charging. Charging can occur under bombardment by electrons emitted from the cathode or under charge injection at electrode-insulator interfaces. Therefore, the measurement of the energetic characteristics of charged insulators is used for selecting materials and improving technologies (surface finishing, insulator-electrode brazing, etc.). Many space charge characterization techniques that have been developed over the last twenty years measure an average charge distribution. However, this measurement is not straight-forwardly correlated with the electric strength. A technique that uses the Rutherford's diffusion of low energy electrons deflected by trapped charges seems more promising. Measurement of the permittivity, /spl epsi//sub r/, allows calibration of the apparatus and determination of the electron dose that can be stored in the material before energy relaxation. The variation of the trapping efficiency as function of the temperature gives the trap energy distribution. The parameters that trigger the energy relaxation are determined by varying the temperature, the electric field or the mechanical stress.
Oxidative addition of aryl sulphides to low-valent nickel species (1986)

Exposure of diaryl sulphides to tris(tri-n-butyl)phosphinonickel(0) is shown to lead to oxidative addition products, one of which has been characterized by n.m.r. spectral analysis and another by single-crystal X-ray analysis.