gebhart/patrepeval huggingface dataset:
Material parameter measurements at high temperatures (1988)

Alternate fixtures of techniques for the measurement of the constitutive material parameters at elevated temperatures are presented. The technique utilizes scattered field data from material coated cylinders between parallel plates or material coated hemispheres over a finite size groundplane. The data acquisition is centered around the HP 8510B Network Analyzer. The parameters are then found from a numerical search algorithm using the Newton-Ralphson technique with the measured and calculated fields from these canonical scatters. Numerical and experimental results are shown.
Debit card usage: an examination of its impact on household debt (2007)

This paper investigates debit card usage and its impact on household debts, using the 2004 Survey of Consumer Finances. By conducting simultaneous equation modeling, we examine how debit card users are different from non-users, and whether debit card usage influences household debt. We find that, after controlling for selection bias, the use of debit cards is negatively associated with household debt. We also find that those with revolving debt tendencies (i.e., carrying outstanding balances on credit cards) are more likely to use debit cards than those without a revolving debt tendency. We conclude that debit card usage discourages the accumulation of household debt rather than that debit card users tend to be financially conscientious. © 2007 Academy of Financial Services. All rights reserved. JEL classifications: D12; D14
About Roy Glauber (2023)

Abstract We recount the life, work, and legacy of the theoretical physicist Roy Glauber (1925–2018). Admitted to Harvard at age 16, called upon to participate in the Manhattan Project at age eighteen, and appointed to the Harvard Physics faculty at age 29, Glauber is credited with seminal contributions to three separate fields of physics: nuclear scattering, statistical physics, and foundational work in quantum optics, which earned him the 2005 Nobel Prize in Physics. Over decades, Glauber was also a dedicated teacher of high‐school, college, and graduate students. His pedagogical gifts are reflected in his lucid papers that read as if they were written yesterday. Key points perspective on the life, work, and legacy of the 2005 Physics Nobel laureate Roy Glauber (1925–2018) impact of Glauber's contributions on large swaths of physics, from nuclear to optical to condensed matter Glauber's work in quantum optics has nurtured burgeoning areas of quantum science and engineering
A Fast Iterative Method for Eikonal Equations (2008)

In this paper we propose a novel computational technique to solve the Eikonal equation efficiently on parallel architectures. The proposed method manages the list of active nodes and iteratively updates the solutions on those nodes until they converge. Nodes are added to or removed from the list based on a convergence measure, but the management of this list does not entail an extra burden of expensive ordered data structures or special updating sequences. The proposed method has suboptimal worst-case performance but, in practice, on real and synthetic datasets, runs faster than guaranteed-optimal alternatives. Furthermore, the proposed method uses only local, synchronous updates and therefore has better cache coherency, is simple to implement, and scales efficiently on parallel architectures. This paper describes the method, proves its consistency, gives a performance analysis that compares the proposed method against the state-of-the-art Eikonal solvers, and describes the implementation on a single instruction multiple datastream (SIMD) parallel architecture.
Synthesis and pharmacological study of some new beta-(dialkylaminomethyl)- gamma-butyrolactones and their tetrahydrofuran analogues. (1996)

This paper describes the synthesis of beta-(dialkylaminomethyl)-gamma- butyrolactones (6 and 15) and their tetrahydrofuran analogs 7 and 16. Their convulsant activity was studied on mice and could display an antiGABAergic component, but, unlike the alpha-(dialkylaminomethyl)- gamma-butyrolactones, no antiglycinergic component was detected. The possibility of an activation of the glutamatergic receptors (NMDA), by indirect stimulation of their glycinergic site, by the tetrahydrofurans analogs 7 could be considered. These compounds exhibited, at low doses (1/3 to 1/20 of their convulsant doses), an anticonvulsant action in the maximal electroshock test and this is in agreement with the abovementioned possibility.
Performance evaluation of waterproofing membrane protective systems for concrete bridge decks. Final report 3 January-3 November 1983 (1983)

This study develops a methodology for field appraisal and evaluates the effectiveness of three selected waterproofing membrane installations presently in service in the State of Washington. Based on the information obtained, none of the test installations had completely sealed the passage of salt into the concrete decks. 'Active' and 'uncertain' corrosion potentials existed at the rehabilitated portions; however, a decrease in corrosion activity since the time of rehabilitation was noted. Concrete deterioration after rehabilitation has occurred mainly within the boundaries of the repair work and original concrete, and it is more evident in areas with a shallower rebar depth. It is recommended that future research include a greater number of bridge decks. In addition, service life performance data should be obtained through long-range monitoring of the installations.
A theory of measuring, electing, and ranking (2007)

The impossibility theorems that abound in the theory of social choice show that there can be no satisfactory method for electing and ranking in the context of the traditional, 700-year-old model. A more realistic model, whose antecedents may be traced to Laplace and Galton, leads to a new theory that avoids all impossibilities with a simple and eminently practical method, "the majority judgement." It has already been tested.
Experimental determination of DT yield in high current DD Dense Plasma Focii (2013)

Summary form only given. Dense Plasma Focii (DPF), which utilize deuterium gas to produce 2.45 MeV neutrons, may in fact also produce DT fusion neutrons at 14.1 MeV due to the triton production in the DD reaction. If beam-target fusion is the primary producer of fusion neutrons in DPFs, it is possible that ejected tritons from the first pinch will interact with the second pinch, and so forth. The 2 MJ DPF at National Security Technologies' Losee Road Facility is able to, and has produced, over 1E12 DD neutrons per pulse, allowing an accurate measurement of the DT/DD ratio. The DT/DD ratio was experimentally verified by using the (n, 2n) reaction in a large piece of praseodymium metal, which has a threshold reaction of 8 MeV, and is widely used as a DT yield measurement system <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> . The DT/DD ratio was experimentally determined for over 100 shots, and then compared to independent variables such as tube pressure, number of pinches per shot, total current, pinch current and charge voltage.
Mn(III)-Based Oxidative Free-Radical Cyclizations of Unsaturated Ketones (1996)

Mn(III)-based oxidative free-radical cyclization of unsaturated ketones is a versatile synthetic procedure with broad applicability. For example, oxidation of cyclopentanone 1a with 2 equiv of Mn(OAc)(3).2H(2)O and 1 equiv of Cu(OAc)(2).H(2)O in AcOH at 80 degrees C for 1.5 h affords 75% of bicyclo[3.2.1]oct-3-en-8-one 8a and 15% of bicyclo[3.2.1]oct-2-en-8-one 9a. Bridged bicyclic ketones that cannot enolize further are isolated in good yield. Monocyclic beta,gamma-unsaturated ketones that can enolize are oxidized further to give gamma-acetoxy enones. The formation of bicyclo[3.3.1]non-2-en-9-one (57a) in 52% yield from 2-allylcyclohexanone (56a) suggests that kinetically controlled enolization is the rate-determining step in alpha-keto radical formation. A wide variety of examples delineating the scope, limitations, and stereoselectivity of this reaction are presented.
N-myc Downstream-regulated Gene 2, a Novel Estrogen-targeted Gene, Is Involved in the Regulation of Na+/K+-ATPase (2011)

Na(+)/K(+)-ATPase, a plasma membrane protein abundantly expressed in epithelial tissues, has been identified and linked to numerous biological events, including ion transport and reabsorption. In Na(+)/K(+)-ATPase, the β-subunit plays a fundamental role in the structural integrity and functional maturation of holoenzyme. Estrogens are important circulating hormones that can regulate Na(+)/K(+)-ATPase abundance and activity; however, the specific molecules participating in this process are largely unknown. Here, we characterize that N-myc downstream-regulated gene 2 (NDRG2) is an estrogen up-regulated gene. 17β-Estradiol binds with estrogen receptor β but not estrogen receptor α to up-regulate NDRG2 expression via transcriptional activation. We also find that NDRG2 interacts with the β1-subunit of Na(+)/K(+)-ATPase and stabilizes the β1-subunit by inhibiting its ubiquitination and degradation. NDRG2-induced prolongation of the β1-subunit protein half-life is accompanied by a similar increase in Na(+)/K(+)-ATPase-mediated Na(+) transport and Na(+) current in epithelial cells. In addition, NDRG2 silencing largely attenuates the accumulation of β1-subunit regulated by 17β-estradiol. Our results demonstrate that estrogen/NDRG2/Na(+)/K(+)-ATPase β1 pathway is important in promoting Na(+)/K(+)-ATPase activity and suggest this novel pathway might have substantial roles in ion transport, fluid balance, and homeostasis.
Deep reinforcement learning based computation offloading and resource allocation for MEC (2018)

Mobile edge computing (MEC) has the potential to enable computation-intensive applications in 5G networks. MEC can extend the computational capacity at the edge of wireless networks by migrating the computation-intensive tasks to the MEC server. In this paper, we consider a multi-user MEC system, where multiple user equipments (UEs) can perform computation offloading via wireless channels to an MEC server. We formulate the sum cost of delay and energy consumptions for all UEs as our optimization objective. In order to minimize the sum cost of the considered MEC system, we jointly optimize the offloading decision and computational resource allocation. However, it is challenging to obtain an optimal policy in such a dynamic system. Besides immediate reward, Reinforcement Learning (RL) also takes a long-term goal into consideration, which is very important to a time-variant dynamic systems, such as our considered multi-user wireless MEC system. To this end, we propose RL-based optimization framework to tackle the resource allocation in wireless MEC. Specifically, the Q-learning based and Deep Reinforcement Learning (DRL) based schemes are proposed, respectively. Simulation results show that the proposed scheme achieves significant reduction on the sum cost compared to other baselines.
32-nucleotide deletion, associated with defence against hiv/aids, is a predominant mutation of CCR5 gene in the population of Georgia. (2005)

There is a special interest to investigate genetic peculiarities in the populations with a low HIV seroprevalence. Despite of presence of high-risk conditions for rapid spread of HIV/AIDS epidemics in Georgia, the prevalence of this infection in the country remains very low. We studied polymorphisms of CCR5 gene in Georgians. Blood samples from 190 women randomly selected from the cohort of pregnant women involved in the program of prevention of mother-to-child HIV transmission in Georgia have been investigated. Two-step PCR was used to amplify the whole CCR5 genetic sequence. Detection of mutations and polymorphisms was done by dHPLC. All samples showing specific patterns by dHPLC, were sequenced to identify the exact nature of the mutation. It was shown that CCR5-delta32 mutation is a predominant alteration of CCR5 gene among Georgians. All subjects bearing this mutation were heterozygotes. Frequency of delta32 CCR5 allele in the population of Georgia was equal to 5%. Only one case of R223Q mutation and two cases of mutations in the non-coding region of CCR5 gene were also found. Our findings differ from the existing data showing the absence of the CCR5-delta32 mutation among Georgians and provide further support to the hypothesis on a Northeastern European origin of this mutation and North to South gradient of its distribution.
Dosimetry of auricular keloid irradiation. (1982)

The incidental radiation dose of lithium fluoride thermoluminescence dosimeters was recorded during 15 treatments of patients with auricular keloids. Two half-value layers were used, and the results were compared. In both instances, the homolateral lens and thyroid received twice the contralateral dose. The oropharynx dose exceeded the thyroid dose.
Three‐dimensional imaging MS of lipids in atherosclerotic plaques: Open‐source methods for reconstruction and analysis (2016)

Three-dimensional MALDI imaging MS (IMS) is a growing branch of IMS still requiring developments in methodology and technology to make the technique routinely accessible. Many challenges are simply a matter of producing 3D reconstructions and interpreting them in a timely fashion. In this aim and using analysis of lipids from atherosclerotic plaques from a human carotid and mouse aortic sinuses, we describe 3D reconstruction methods using open-source software that provides high-quality visualization and rapid interpretation through multivariate segmentation of the 3D IMS data. Multiple datasets were generated for each sample and we provide insight into simple means to correlate the separate datasets.
A Multi-intelligent Agent Architecture for Knowledge Extraction: Novel Approaches for Automatic Production Rules Extraction (2014)

In this paper, multi-intelligent agent architecture has been proposed for automatic knowledge extraction from its resources (domain experts and text documents). The extracted knowledge should be stored in a knowledge base to be used later by knowledge-based systems. This article aims to produce an effective knowledge base by cooperation between expert mining and text mining techniques. Firstly, we are constructing an Expert Mining Intelligent Agent (EMIA) able to interview with domain experts for mining problem solving knowledge as production rules in a specific diagnosis domain. It is also responsible for extracting the patterns or linguistic expressions and save it in a conceptual database. Secondly, we are constructing a Text Mining Intelligent Agent (TMIA) capable of extracting production rules from a text document corpus. The achievement of that extraction can be performed by a text document categorization based on a traditional term weighting scheme (TF-IDF) and using the Stanford parser to analyze and produce a parsing tree for each sentence in that document. Then, the TMIA looks for all causal words and takes them as separation words to generate patterns and sub-patterns based on the conceptual database. Finally, the TMIA stores those patterns and sub-patterns in a pre-formatted template and displays it to a domain expert for a modification process to construct accurate production rule.
Pathogenicity of Highly Pathogenic Avian Influenza Virus H5N1 in Naturally Infected Poultry in Egypt (2015)

Highly pathogenic avian influenza virus (HPAIV) H5N1 has been endemic in Egypt since 2006, and there is increasing concern for its potential to become highly transmissible among humans. Infection by HPAIV H5N1 has been described in experimentally challenged birds. However, the pathogenicity of the H5N1 isolated in Egypt has never been reported in naturally infected chickens and ducks. Here we report a 2013 outbreak of HPAIV H5N1 in commercial poultry farms and backyards in Sharkia Province, Egypt. The main symptoms were ecchymosis on the shanks and feet, cyanosis of the comb and wattles, subcutaneous edema of the head and neck for chickens, and nervous signs (torticollis) for ducks. Within 48-72 hrs of the onset of illness, the average mortality rates were 22.8-30% and 28.5-40% in vaccinated chickens and non-vaccinated ducks, respectively. Tissue samples of chickens and ducks were collected for analyses with cross-section immunohistochemistry and real-time RT-PCR for specific viral RNA transcripts. While viral RNA was detected in nearly all tissues and sera collected, viral nucleoprotein was detected almost ubiquitously in all tissues, including testis. Interestingly, viral antigen was also observed in endothelial cells of most organs in chickens, and clearly detected in the trachea and brain in particular. Viral nucleoprotein was also detected in mononuclear cells of various organs, especially pulmonary tissue. We performed phylogenetic analyses and compared the genomic sequences of the hemagglutinin (HA) and nonstructural proteins (NS) among the isolated viruses, the HPAIV circulated in Egypt in the past and currently, and some available vaccine strains. Further analysis of deduced amino acids of both HA and NS1 revealed that our isolates carried molecular determinants of HPAIV, including the multibasic amino acids (PQGERRRK/KR*GLF) in the cleavage site in HA and glutamate at position 92 (D92E) in NS1. This is the first report of the pathogenicity of the HPAIVH5N1 strain currently circulating in naturally infected poultry in Egypt, which may provide unique insights into the viral pathogenesis in HPAIV-infected chickens and ducks.
Protein glutathionylation increases in the liver of patients with non‐alcoholic fatty liver disease (2007)

Protein glutathionylation significantly increases in livers with NAFLD, strongly suggesting that oxidative injury plays a crucial role in this disease. Furthermore, the marked increase of protein glutathionylation, in correlation with collagen VI immunoreactivity, suggests a link between the redox status of hepatic protein thiols and fibrosis.
Present And Future Applications For Laser Processing Of Hybrids And Semiconductors (1985)

Present and future development of laser processing as a production technique for modifying semiconductor devices, improving yields, and decreasing developmbnt times are described. Current applications covered include thick-and thin-film resistor trimming, deposited film and polysilicon resistors on silicon trimming and redundant memory repair. Emerging applications include microcircuit mask making and capacitor trimming. Examples of processes still under development include selective annealing, minority-carrier lifetime doping, and device diagnostics by laser imaging.
The psychology of Harry F. Harlow: A bridge from radical to rational behaviorism (1997)

Abstract Harry Harlow is credited with the discovery of learning set, a process whereby problem solving becomes essentially complete in a single trial of training. Harlow described that process as one that freed his primates from arduous trial‐and‐error learning. The capacity of the learner to acquire learning sets was in positive association with the complexity and maturation of their brains. It is here argued that Harlow's successful conveyance of learning‐set phenomena is of historic significance to the philosophy of psychology. Learning set is said to reflect the affirmation or rejection of hypotheses. Hypotheses are generated by the learner's brain, not its muscles. Thus, learning‐set research served to advance the perspective that even nonhuman primates think and that their thinking reflects the active processing of information accrued from efforts to solve problems. Their learning processes are not simply the strengthening of some motor responses over others. Hence, learning‐set research served to advance studies of animals as rational agents. This trend is serving to supplant the radical‐behavioristic models, formulated earlier this century, with models predicated on rational processes for animals’ complex learning and behavior.
Evidence for a Substrate Regulation of Triglyceride Lipolysis in Human Skeletal Muscle (1985)

Glycerol release from the human forearm which is generally used as a semiquantitative index of intramuscular lipolysis was studied under different hormonal influence and substrate supply in healthy volunteers and juvenile diabetics using the forearm technique. Acute insulin deficiency in juvenile diabetics failed stimulating the rate of muscular lipolysis since the rates of glycerol release in normals and diabetics were the same. In addition, in normal volunteers high physiological levels of insulin caused by an intraarterial infusion of the hormone exhibited no effect on the glycerol release from deep forearm tissue. Similarly, an intraarterial infusion of metaproterenol did not accelerate muscular glycerol release in normal man. However, in juvenile diabetics in acute insulin deficiency the same dose of the catecholamine increased the rate of muscular glycerol production. Elevated substrate supply during intravenous infusion of glucose or fructose yielded increased uptake of glucose and fructose into the deep forearm tissue and thereby promptly blocked muscular glycerol release in normal volunteers and in juvenile diabetics. These findings suggest that the rate of lipolysis in muscle tissue is not primarily under the control of hormones but rather by substrate supply.
Two mutations of the lutropin/choriogonadotropin receptor that impair signal transduction also interfere with receptor-mediated endocytosis. (1996)

The experiments presented herein were designed to probe a potential role for the activation of the LH/CG receptor (LHR) on the receptor-mediated endocytosis of human CG (hCG). Two mutants of the rat LHR (rLHR) that bind the hormone with high affinity but are deficient in signal transduction were prepared by mutating highly conserved residues that have been previously shown to be important in signal transduction in other members of the G protein-coupled receptor family. Mutation of a highly conserved aspartic acid in the second transmembrane domain of the rLHR (designated rLHR-D383N) does not affect hCG binding but impairs signal transduction. When compared with cells expressing an equivalent density of wild type rLHR (rLHR-wt), concentration-response curves for the hCG-stimulated cAMP accumulation in cells expressing rLRH-D383N- are characterized by an 18-fold increase in the EC50 but no change in the maximal response. Cells expressing rLHR-D383N also display a 4- to 5-fold increase in the half-life of internalization of hCG. Mutation of a highly conserved arginine in the second intracellular loop of the rLHR (designated rLHR-R442H) also does not affect hCG binding but impairs signal transduction. When compared with cells expressing an equivalent density of rLHR-wt, concentration-response curves for the hCG-stimulated cAMP accumulation in cells expressing rLHR-R442H are characterized by a 7-fold increase in the EC50 and a 6- to 10-fold decrease in the maximal response. Cells expressing rLHR-R442H also display a 1.5- to 2-fold increase in the half-life of internalization of hCG. These results, together with the finding that an antagonist of hCG is internalized more slowly than hCG, suggest that the activation of the LHR is needed for the efficient endocytosis of the bound hCG.