gebhart/patrepeval huggingface dataset:
Phase I study of the combination of balixafortide (CXCR4 inhibitor) and eribulin in HER2-negative metastatic breast cancer (MBC) patients (pts). (2017)

2555 Background: Balixafortide (POL6326) is a cyclic peptide and a potent, selective antagonist of the chemokine receptor CXCR4. Evidence suggests that CXCR4 inhibition interferes with the tumor-protective microenvironment and sensitizes tumor cells to chemotherapy. The combination of balixafortide (B) and eribulin (E) was safe with early signs of efficacy in the dose escalation part of this study. Methods: The expanded cohort of thisopen label phase I study was designed to assess the anti-tumor activity, safety and pharmacokinetics of the addition of the recommended phase 2 dose (RP2D) of B to E in pts with MBC and with any CXCR4 expression level at the tumor site. Patients received E (1.4 mg/m 2 ) on days 2 and 9, flanked by B (5.5 mg/kg) on days 1-3, and 8-10 of 21-day cycles. Results: 24 pts with relapsed MBC (median age 59 [33-82]) were enrolled in the expanded cohort. Median number of prior chemotherapies for MBC was 2 (range 1-3). 20/24 (83%) pts were ER and/or PR positive; 3/24 (13%) pts had TNBC. Objective response rate (ORR) was 33%. 8/24 (33%) pts achieved a partial response and 4/24 (17%) pts had meaningful (≥ 6 months) stable disease for a Clinical Benefit Ratio of 50%. Median duration of treatment was 15.3 weeks (range 5-40) with 11 pts still on treatment. The most common Gr 3-4 adverse events were neutropenia (9/24, 38%) and leucopenia (3/24, 13%); 2 pts had febrile neutropenia and 1 patient died from sepsis. 15/24 (63%) pts experienced histamine-like infusion reactions related to B that were manageable with anti-histamines. Conclusions: The therapeutic activity of this treatment regimen appears promising with an ORR of 33% in patients with advanced MBC. B (5.5 mg/kg) can be combined safely with E (1.4 mg/m 2 ) and the safety profile resembles E monotherapy as previously reported. This is the first study of the treatment combination of E with B in relapsed MBC pts. Further confirmatory studies are being considered. Clinical trial information: NCT01837095.
Temporal profile of brain injury and inflammatory serum markers in carotid artery stenting (2013)

Objective: Distal embolization is the most frequently complication associated to carotid artery stenting (CAS). The clinical significance of this phenomenon can not easily quantifiable, because it is usually asymptomatic, but recent studies have focused on deleterious log-term effect of micro-embolic infarcts on cerebral function, which can be early also detected by measuring serum markers of brain injury (S100beta protein and neuronal-specific enolase, NSE). The purpose of this study was to evaluate the relationship between the temporal profile of serum concentration of S100beta, NSE and inflammatory markers (hsCRP and fibrinogen) in asymptomatic patient underwent CAS. Methods: We enrolled 35 consecutive asymptomatic patients undergoing CAS from Dec 2008 until Nov 2011. Venous blood samples were obtained from each patient preoperatively (basal) at 2, 12, 24 hours and at 30 days after the end of the procedure. Characterization of plaque types was performed preoperatively by CT scan with 64 slices. Results: We observed a significant increase of S100B protein at 2 hours (120.9±171.4 pg/mL; p=0.014) post-CAS respect to basal values (62.9±48.0). The higher levels of S100B were observed in lipid rich (285.7±405.5; p=ns) and calcific (85.8±34.4; p=0.03) plaques respect to fibrous type (37.5±22.0). NSE significantly declined at 24 hours (6.5±3.9 ng/mL; p=0.0002) respect to basal (9.2±5.7) and return at preoperative levels at 1 month (8.9±5.5; p=0.037). At 24 hours we also observed an increase of CRP levels (1.136±1.340 ng/mL; p=0.04) in comparison to baseline (0.55±0.42). A similar time course was observed for fibrinogen values with a peak at 24 hours but this growth was not statistically significant. Conclusions: CAS in asymptomatic patients leads to subclinical alteration of cerebral function revealed by the increase of S100beta. In particular calcific and lipid rich plaques seem to be related to a greater distal embolization and consequent more significant cerebral injury.
ELECTRON BEAM DYNAMICS STUDY AT SIAM PHOTON SOURCE (2001)

The Siam Photon Source is the first storage ring for synchrotron radiation research in Thailand. The light source accelerator system includes an injector linac at 40 MeV, a booster synchrotron at 1.0 GeV and a storage ring at 1.0 GeV electron energy. The storage ring is composed of four identical cells with a total circumference of 81.3 m. The lattice is modified into DBA from FODO that was previously designed in SORTEC. In this paper, the study of electron beam dynamics in low energy beam transport, booster synchrotron, high energy beam transport, and storage ring has been presented.
Graph Based Interference Analysis and Resource Allocation in mmWave IoT Networks (2019)

IoT, Internet of Things is one of the most promising technologies of the fifth-generation (5G). The buzz is all about creating smart environments and getting every type of device connected to the internet. 5G will revolutionize the speed at which the data is transferred, and how much can be transferred at one time. Millimeterwave (mmWave) and massiveMIMO are the two key technologies which plays an essential role to address this problem and represents the next frontier of wireless technology, bringing 10 times higher frequencies and 10 times wider channel bandwidths than the most advanced Wi-Fi and cellular technologies. Millimeter-wave technology is going to become less expensive and easier to deploy, making it a candidate for many wireless connections, including backhaul, personal area networks and LANs. In the world of IoT, this translates into instant, reliable machine communication across every industry and application possible [1]. As the density of wireless devices increases and requirements of all their applications change drastically, it becomes more challenging to provide them connectivity within the stipulated amount of time to deliver the needs. As a result, several challenges such as improving the network capacity, coverage area, efficient data capturing, security, signal processing becomes a necessity to be handled. In line with these, a very recent area of research is to exploit mm-wave band for use in 5G IoT implementations unlike the traditional usage of Zigbee and Bluetooth technologies. One of the technical challenges in this broad area of research is coordinating communication among large number of devices ensuring highly reliable links and investigate on the potential of Resource allocation to envision a diverse set of usage scenarios and applications.
Compact Quantum‐Dot Microbeads with Sub‐Nanometer Emission Linewidth (2021)

Fluorescent microbeads are widely used for applications in life sciences and medical diagnosis. The spectral contrast and sharpness of photoluminescence are critical in the utilities of microbeads for imaging and multiplexing. Here, we demonstrate microbeads capable of generating single-peak laser emission with a sub-nanometer linewidth. The microbeads are made of quantum dots that are tightly packed and crosslinked via ligand exchange for high optical gain and refractive index as well as material stability. Bright single-mode lasing with no photobleaching is achieved with particle diameters as small as 1.5 μm in the air. Sub-nm lasing emission is maintained even inside high-index surroundings, such as organic solvents and biological tissues. Feasibility of intracellular tagging and multi-color imaging <i>in vivo</i> is demonstrated.
Synthesis and studies of a tetradecanuclear manganese(ii)/(iii) cage (2002)

A novel Mn14 cluster is reported; this is a new nuclearity for manganese cages and highly unusual in that the ligands are not exclusively oxygen donors.
Cloud-GAN: Cloud Removal for Sentinel-2 Imagery Using a Cyclic Consistent Generative Adversarial Network (2018)

International audience
Stochastic Adaptive Neural Architecture Search for Keyword Spotting (2018)

The problem of keyword spotting i.e. identifying keywords in a real-time audio stream is mainly solved by applying a neural network over successive sliding windows. Due to the difficulty of the task, baseline models are usually large, resulting in a high computational cost and energy consumption level. We propose a new method called SANAS (Stochastic Adaptive Neural Architecture Search) which is able to adapt the architecture of the neural network on-the-fly at inference time such that small architectures will be used when the stream is easy to process (silence, low noise, ...) and bigger networks will be used when the task becomes more difficult. We show that this adaptive model can be learned end-to-end by optimizing a trade-off between the prediction performance and the average computational cost per unit of time. Experiments on the Speech Commands dataset show that this approach leads to a high recognition level while being much faster (and/or energy saving) than classical approaches where the network architecture is static.
From trees to seeds: On the inference of the seed from large trees in the uniform attachment model (2017)

We study the influence of the seed in random trees grown according to the uniform attachment model, also known as uniform random recursive trees. We show that different seeds lead to different distributions of limiting trees from a total variation point of view. To do this, we construct statistics that measure, in a certain well-defined sense, global “balancedness” properties of such trees. Our paper follows recent results on the same question for the preferential attachment model.
Protein Folding: An Antagonistic Reaction of Spontaneous Folding and Diffusion Limited Aggregation in Nature (2007)

Protein folding may follow a spontaneous process or a reaction-path directed process, determined by various folding transition boundaries due to intrinsic properties of the protein. A general first-order-like state-transition model predicts that a protein might be trapped in an aggregated state when the folding path crosses the transition boundary. Both experimental study and molecular simulation indicated that protein within this particular transition region might involve intermolecular interactions. Therefore, a direct folding process may have been a combination of an antagonistic reaction of spontaneous folding and a diffusion limited aggregation. In this paper, the protein folding mechanism and the theoretical basis of time limited diffusion/aggregation process are elaborated. The application of auto-correlation function in time dependent biological studies is also discussed.
Influence of Estrogen and Polyamines on Mifepristone-induced Apoptosis in Prostate Cancer Cells (2004)

In LNCaP cells, MIF induces apoptosis through ROS production. The expression of p53 protein, caspase-3 activation and PARP cleavage accompanied the process of apoptosis. The apoptotic processes were inhibited by E(2), but polyamines only inhibited the ROS production, implying the multifunctional role of E(2), in addition to its role as a free radical scavenger.
Experimental Performance Comparison of Emerging Low Power Wide Area Networking (LPWAN) Technologies for IoT (2019)

In this work we present experimental results on the evaluation of two commercial integrated circuits for IoT connectivity, using a systematic approach. One devoted to LoRa and the other to IEEE 802.15.4g, which is the physical layer adopted by the WI-SUN Alliance. The goal behind this evaluation is to present results to support those who will make use of LoRa or IEEE802.15.g/Wi-SUN or other type of connectivity to compare technologies in a fair fashion. The results show that there are differences between datasheet values and the measures collected during the experiments. There are a number of reasons for this divergence, such as the setup, transmitted packet length, equipment calibration and test specifications. This shows the importance of a systematical approach when comparing technologies.
EQUATIONS OF STATE OF LIQUID AND GASEOUS NORMAL HYDROGEN AND THE APPLICATION OF MULTIPLE REGRESSION TECHNIQUES TO CURVE FITTING (1959)

Analytical expressions are presented which describe the P-V-T surface of gaseous and liquid normal hydrogen with a precision of 5%. The use of multiple regression techniques for the reduction of experimertal data is discussed as well as adaption for use with an IBM-704 computer. (auth)
Effects of angiotensins on cellular hypertrophy and c‐fos expression in cultured arterial smooth muscle cells (1992)

An increase in cell size and protein content was observed when quiescent arterial smooth muscle cells in culture were incubated with either angiotensin II or III. These effects were inhibited by the specific angiotensin type-1 receptor antagonist losartan (DuP753) but not by CGP42112A. In parallel, a transient and dose-dependent induction of c-fos was demonstrated not only with angiotensins II and III but also with angiotensin I. Both angiotensins II and III exerted their maximal effect at 1 microM, while angiotensin I needed a tenfold-higher concentration to exert an identical effect. As for hypertrophy, losartan also inhibits angiotensin-induced c-fos expression, suggesting that this gene may be involved into the hypertrophic process. Angiotensin-I-mediated c-fos induction is partially inhibited by the angiotensin-converting enzyme inhibitors captopril and trandolaprilate; given that an angiotensin-converting enzyme activity was detected in these smooth muscle cell cultures, these results suggest that angiotensin-I-induced c-fos expression is mediated in part via angiotensin-I conversion to angiotensin II, but also by other unidentified pathway(s). Angiotensin I could essentially induce smooth muscle cell hypertrophy by indirect mechanisms, while angiotensins II and III act directly on smooth muscle cells.
Template-free formation of oriented oxide nanowalls via topotactic-like pseudomorphic transformation: [110]-MgO(111) nanowall arrays (2022)

The template-free formation of oriented MgO nanowall arrays is successfully achieved by a two-step synthesis route of (i) electrodeposition of vertically aligned hydroxide and (ii) its topotactic-like pseudomorphic transformation to oxide.
Investigation of the ripple pattern formation on nanocrystalline diamond film surfaces during reciprocating sliding against Si3N4 balls (2013)

status: Published
Immunoregulatory and Prodifferentiating Effects of 1,25-Dihydroxyvitamin D3 in Human Mononuclear Cells (2020)

Vitamin D is classically recognized as a hormone which regulates mineral ion homeostasis in mammalian and avian species. The nutritional importance of vitamin D in the maintenance of normal, human bone metabolism was unfortunately demonstrated with epidemic frequency in the urban centers of industrialized Europe and America in the nineteenth and early twentieth centuries. The utility of simple sunlight exposure in curing rachitic bone disease was first demonstrated by Huldschinsky in 1919, who suggested that environmental sunlight exposure resulted in the endogenous production of a potent “antirachitic substance.” The possibility that 1,25-(OH)2 -D3 may modulate the mammalian immune response was raised by three somewhat divergent lines of evidence.
Innovative Concept for sustainable treatment of municipal wastewater (2005)

Current systems for centralised treatment of municipal wastewater are technically highly efficient and cost effective. However, from an environmental point of view these systems are not very sustainable. An innovative concept for a more sustainable treatment of municipals wastewater is proposed. The system is primarily based on the application of UF/MF and RO membranes and anaerobic digestion. A preliminary study towards the feasibility of this innovative concept leads to the conclusion that it has the potential to recover nutrients and effluent for reuse, to produce substantially higher amounts of biogas than conventional systems, and requires a very small footprint. The costs are higher but probably acceptable. Further research is necessary to elaborate and develop this system for practical application. Involvement of stakeholders is expected to be necessary for the further development of this system.
BEACON: Scalable Near-Data-Processing Accelerators for Genome Analysis near Memory Pool with the CXL Support (2022)

Genome analysis benefits precise medical care, wildlife conservation, pandemic treatment (e.g., COVID-19), and so on. Unfortunately, in genome analysis, the speed of data processing lags far behind the speed of data generation. Thus, hardware acceleration turns out to be necessary. As many applications in genome analysis are memory-bound, Processing-In-Memory (PIM) and Near-Data-Processing (NDP) solutions have been explored to tackle this problem. In particular, the Dual-Inline-Memory-Module (DIMM) based designs are very promising due to their non-invasive feature to the cost-sensitive DRAM dies. However, they have two critical limitations, i.e., performance bottle-necked by communication and the limited potential for memory expansion. In this paper, we address these two limitations by designing novel DIMM based accelerators located near the dis-aggregated memory pool with the support from the Compute Express Link (CXL), aiming to leverage the abundant memory within the memory pool and the high communication bandwidth provided by CXL. We propose BEACON, Scalable Near-Data-Processing Accelerators for Genome Analysis near Memory Pool with the CXL Support. BEAC-ON ad-opts a software-hardware co-design approach to tackle the above two limitations. The BEACON architecture builds the foundation for efficient communication and memory expansion by reducing data movement and leveraging the high communication bandwidth provided by CXL. Based on the BEACON architecture, we propose a memory management framework to enable memory expansion with unmodified CXL-DIMMs and further optimize communication by improving data locality. We also propose algorithm-specific optimizations to further boost the performance of BEACON. In addition, BEACON provides two design choices, i.e., BEACON- D and BEACON-S. BEACON-D and BEACON-S perform the computation within the enhanced CXL-DIMMs and enhanced CXL-Switches, respectively. Experimental results show that compared with state-of-the-art DIMM based NDP accelerators, on average, BEACON-D and BEACON-S improve the performance by 4. 70x and 4. 13x, respectively.
Evidence for the recent origin of a bacterial protein-coding, overlapping orphan gene by evolutionary overprinting (2015)

Since nog1 is of recent origin, non-essential, short, weakly expressed and only marginally involved in E. coli's central metabolism, we propose that this gene is in an initial stage of evolution. While we present specific experimental evidence for the existence of a fourth overlapping gene in enterohemorrhagic E. coli, we believe that this may be an initial finding only and overlapping genes in bacteria may be more common than is currently assumed by microbiologists.
Lifetime measurements in theS122andD32,522sequences of indium (1983)

Natural radiative lifetimes in the $5{s}^{2}\mathrm{ns}^{2}S_{\frac{1}{2}}$ and $5{s}^{2}\mathrm{nd}^{2}D_{\frac{3}{2},\frac{5}{2}}$ ($n\ensuremath{\le}20$) sequences of indium have been measured using pulsed laser excitation of an atomic beam. The uv pulses were produced by a YAG-pumped, or alternatively, an excimer-pumped dye-laser system. While the $S$-state lifetimes show a normal ${({n}^{*})}^{3}$ behavior, the $D$ sequences are strongly perturbed. The lifetimes of the $5s5{p}^{2}^{4}P$ states were found to be $J$ dependent.
A Convenient Method for the Synthesis of DNA-Recognizing Polyamides in Solution (2000)

A convenient method for the synthesis of polyamides containing N-methylpyrrole (Py) and N-methylimidazole (Im) in solution has been developed. Most of the building blocks have been prepared by a haloform reaction in a simple way that column chromatography can be avoided. By use of the DCC/HOBT coupling reaction, the building blocks prepared have been effectively connected to construct a variety of subchains and polyamides without employing amino protection and deprotection. By use of the present method, an eight-ring polyamide, PyPyPyPygammaPyImImPybetaDp (gamma is gamma-aminobutyric acid, beta is beta-alanine, Dp is N, N-dimethylpropyldiamine), has been synthesized by the coupling of two four-ring subchains in one step.
Transjugular liver biopsy: a review of 461 biopsies. (1985)

Transjugular liver biopsy was performed in a large series of patients for whom routine percutaneous biopsy was contraindicated; most of the patients had severe liver disease associated with coagulopathies or massive ascites. Of the 461 biopsies performed over a 7-year period, adequate specimens for histologic diagnosis were obtained in 425; in 14 (3.3%), the biopsy provided a false-negative result. Minor complications such as neck pain, hematoma at the puncture site, or pyrexia occurred in 79 patients (17.1%). Serious complications were encountered in six patients (1.3%) (two with cardiac arrhythmias; four with intraperitoneal hemorrhage following capsular perforation), with an overall mortality rate for the series of 0.22%. Modification of the technique--taking the biopsy with the catheter positioned centrally rather than wedged peripherally--has reduced the occurrence of capsular perforation without affecting the success rate. Transjugular liver biopsy is a valuable technique that provides diagnostic information in a high proportion of cases in which conventional percutaneous biopsy is contraindicated.
Bioactive Lipodepsipeptides Produced by Bacteria and Fungi (2022)

Natural products are a vital source for agriculture, medicine, cosmetics and other fields. Lipodepsipeptides (LPDs) are a wide group of natural products distributed among living organisms such as bacteria, fungi, yeasts, virus, insects, plants and marine organisms. They are a group of compounds consisting of a lipid connected to a peptide, which are able to self-assemble into several different structures. They have shown different biological activities such as phytotoxic, antibiotic, antiviral, antiparasitic, antifungal, antibacterial, immunosuppressive, herbicidal, cytotoxic and hemolytic activities. Their biological activities seem to be due to their interactions with the plasma membrane (MP) because they are able to mimic the architecture of the native membranes interacting with their hydrophobic segment. LPDs also have surfactant properties. The review has been focused on the lipodepsipeptides isolated from fungal and bacterial sources, on their biological activity, on the structure-activity relationships of some selected LPD subgroups and on their potential application in agriculture and medicine. The chemical and biological characterization of lipodepsipeptides isolated in the last three decades and findings that resulted from SCI-FINDER research are reported. A critical evaluation of the most recent reviews dealing with the same argument has also been described.
The Effect of Steam Ingestion on Transonic Rotor Stall Margin (2007)

The adverse effect of high temperature water vapor on the stall margin of a transonic compressor rotor is investigated. This type of flow condition is experienced during the takeoff of carrier born aircraft. An experiment is designed to replicate these flow conditions on a transonic compressor test rig. The transient inlet conditions are measured and the changes in gas properties as well as the reduction in stall margin for differing steam inlet pressures are presented. High speed data measurements are used to investigate the initial conditions of the compressor before steam is introduced to the flow. Evidence of pre-cursors rotating at near half rotor speed are found and the strength of these appear to give an indication of the compressor’s susceptibility to stall.