gebhart/patrepeval huggingface dataset:
Safety and tolerability of antibacterial prophylaxis during the postengraftment phase after myeloablative hematopoietic stem cell transplantation (2005)

Background: Bacterial infections are frequent complications of the postengraftment phase after ablative allogeneic HSCT. This pilot study investigated the safety and tolerability of administering antibiotic (ABX) prophylaxis from when patients tolerated PO medications after engraftment (ANC> 1500/mm3 for 2 days) through day +100. Methods: Twenty-three engrafted allogeneic BMT patients at OHSU, received moxifloxacin (MOXI) 400 mg po daily. Drug was started on discontinuation of any ABX used for the treatment of pre-enrollment bacterial infection or neutropenic fever. Rates of bacterial infection, bacteremia, and colonization were recorded. Comparisons were made with a cohort of 60 consecutive patients undergoing ablative BMT at OHSU without ABX prophylaxis from 2001 to 2002. Results: The median duration of MOXI prophylaxis was 77 days (range, 7–87 days). Five patients had dose interruptions, 4 due to nausea associated with GVHD, and 1 patient withdrew from the study. Three patients had dose interruptions during empiric ABX therapy for possible bacterial infection. Overall, MOXI was well tolerated in this patient population, with 5 episodes of grade 3/4 toxicity possibly related to study drug (2 orthostatic hypotension in 1 patient, 2 nausea, and 1 hypertension). Five patients had episodes of transaminitis that were unlikely to be due to the study medication and that responded to discontinuation of azole antifungal therapy (4) or to treatment of liver GVHD (1). No cardiac arrhythmias were observed. Compared with historic controls, a marked decrease in postengraftment bacterial infections was observed. In the control cohort, 16 patients experienced 17 episodes of Gram-negative infections and 22 patients had 25 episodes of symptomatic Gram-positive infections during the postengraftment phase without prophylaxis. In contrast with MOXI prophylaxis, 2 patients experienced 3 Gram-negative infections (χ2 test, P= .079), 1 patient had an anaerobic infection, and 7 patients had 9 symptomatic Gram-positive infections. Two breakthrough bacteremias with Streptococcus viridans occurred and were treated successfully. ABX MICs of Gram-negative isolates showed P. putida sensitive to MOXI and C. freundii resistant, both without drug efflux. Conclusions: Prophylactic MOXI dosed throughout the postengraftment phase has been well tolerated, safe, and associated with fewer bacterial infections compared to historic controls. The efficacy of this prophylaxis strategy will be determined in a planned randomized, placebo-controlled trial.
Proceedings of the International Conference on Underwater Networks & Systems (2019)

The preamble is the signal to trigger the receiver to change from the standby mode to the working mode. Preamble detection is a very important part for underwater acoustic communications, since if the preamble signal is not detected or the receiver is ...
Lectin from Agrocybe aegerita as a Glycophenotype Probe for Evaluation of Progression and Survival in Colorectal Cancer (2014)

Lower AAL specific glycoconjugate expression is a significant favorable prognostic factor for overall and progress free survival in CRC. This is the first report about the employment of AAL for histochemical analysis of cancer tissues. The binding characteristics of AAL means it has potential to become a powerful tool for the glycan investigation and clinical application.
Eliminating lateral color aberration of a high-resolution digital projection lens using a novel genetic algorithm (2007)

Advances in digital image optics have increased the significance of lateral color aberration because it is easily seen in the projected area. The choice of optical glass plays a role in the elimination of lateral color aberration. Current optical software still has difficulty in finding the optimal combination of optical glasses for twelve or more elements in a projection lens, the choice being among at least 300 optical glasses that have been developed. Even the modern damped least squares, a ray-tracing-based method, is limited, owing to its inability to identify an enhanced optical system configuration. As an alternative, this research proposes a new optimization process by using algorithms involving the theory of geometric optics in a projector lens, real encoding, multiple dynamic crossover, and random gene mutation techniques. Results and conclusions show that attempts to achieve negligible axial and lateral color aberration are successful.
Factors that Affect the Quality of Inputs in Manufacturing Organisations: A Case Study of Nampak Kenya Limited (2014)

Supplier selection, Supply base reduction and supplier development among other factors plays a vital role in ensuring that manufacturing organizations get an acceptable quality of inputs from their suppliers. The purpose of this study is to carry out a research on how the above factors affect the quality of inputs in manufacturing organizations in Kenya. Studies carried out by previous researchers showed that manufacturing organizations lose a lot of money and time patching up issue brought about by poor quality of inputs which leads to scrap, rework and repair, trouble shooting, concessions, and downgrading and even losing future job opportunities.
Comparative Fluxome and Metabolome Analysis of Formate as an Auxiliary Substrate for Penicillin Production in Glucose‐Limited Cultivation of Penicillium chrysogenum (2019)

During glucose-limited growth, a substantial input of adenosine triphosphate (ATP) is required for the production of β-lactams by the filamentous fungus Penicillium chrysogenum. Formate dehydrogenase has been confirmed in P. chrysogenum for formate oxidation allowing an extra supply of ATP, and coassimilation of glucose and formate has the potential to increase penicillin production and biomass yield. In this study, the steady-state metabolite levels and fluxes in response to cofeeding of formate as an auxiliary substrate in glucose-limited chemostat cultures at the dilution rates (D) of both 0.03 h<sup>-1</sup> and 0.05 h<sup>-1</sup> are determined to evaluate the quantitative impact on the physiology of a high-yielding P. chrysogenum strain. It is observed that an equimolar addition of formate is conducive to an increase in both biomass yield and penicillin production at D = 0.03 h<sup>-1</sup> , while this is not the case at D = 0.05 h<sup>-1</sup> . In addition, a higher cytosolic redox status (NADH/NAD<sup>+</sup> ), a higher intracellular glucose level, and lower penicillin productivity are only observed upon formate addition at D = 0.05 h<sup>-1</sup> , which are virtually absent at D = 0.03 h<sup>-1</sup> . In conclusion, the results demonstrate that the effect of formate as an auxiliary substrate on penicillin productivity in the glucose-limited chemostat cultivations of P. chrysogenum is not only dependent on the formate/glucose ratio as published before but also on the specific growth rate. The results also imply that the overall process productivity and quality regarding the use of formate should be further explored in an actual industrial-scale scenario.
Data from single nuclei RNA‐sequencing reveals a prodromal gene network response in excitatory neurons of a humanized rat Alzheimer’s disease model (2021)

Abstract Background Despite significant investment into treatments for AD, little progress has been made in bringing new therapeutics to market. Recent failure of monoclonal antibodies targeting Ab plaques to slow disease progression in phase 3 clinical trials, suggests now more than ever it is imperative to identify early disease signatures before symptom onset whose modification may alter disease trajectory. Our collaborating lab recently identified early dysfunction in the transgenic tri‐synaptic hippocampal circuit using in vivo recordings during awake immobility in the TgF344‐AD rat model (doi: 10.1101/2021.05.10.443512). This dysfunction emerges between 6‐9 months, prior to when TgF344‐AD rat shows overt pathology (including Ab plaques, frank neuronal loss, and endogenous tau pathology) at 16 and 26 mo, but not at 6 mo (Towne, 2013). Methods The molecular basis of this trisynpatic circuit dysfunction was explored using 10x Genomics’ v3 gene expression assay to perform snRNA‐seq on freshly dissected hippocampi from 6 mo male and female littermate pairs of Tg and Wt rats (n=16). ∼2000 cells/subject were collected, and cDNA libraries were sequenced (NovaSeq 600) to a depth of ∼120k reads/nuclei. Cell Ranger Pipeline demultiplexed and aligned reads to rat pre‐mRNA reference and generated gene count matrices. A final dataset of 33,079 high quality nuclei were clustered (Louvain graph‐based), and cell‐type specific marke used to determine identity. Identity was collapsed into broad neuronal and glial cell types for differential gene expression (DEG) across genotype (Hurdle Model). Results DEGs revealed profound alterations between genotype in cell types important in the trisynaptic circuit, including dentate granule cells (DGCs), and excitatory neurons (ExcNs). (FDR cutoff=0.05, 1111 (DGCs) and 1070 (ExcN’s) DEGs between genotypes). Pathway enrichment revealed dysregulation relevant to memory function: including decreased synaptogenesis, neurite branching, proliferation, and microtubule and cytoskeleton dynamics. DEG’s were enriched for neurological signs including epilepsy, seizures, hyperactivity, and dementia. Conclusion Prior to development of overt pathology or memory deficits, TgF344‐AD rats display transcriptomic alterations in their excitatory neurons, suggestive of impaired ability to form new connections and susceptibility to aberrant, hyperactivity. Electrophysiological detection, followed by intervention targeting these early alterations in gene expression may prevent progression of disease to a symptomatic stage.
Enhanced Orai1-mediated store-operated Ca2+ channel/calpain signaling contributes to high glucose-induced podocyte injury (2022)

Podocyte injury induced by hyperglycemia is the main cause of kidney dysfunction in diabetic nephropathy. However, the underlying mechanism is unclear. Store-operated Ca<sup>2+</sup> entry (SOCE) regulates a diversity of cellular processes in a variety of cell types. Calpain, a Ca<sup>2+</sup>-dependent cysteine protease, was recently shown to be involved in podocyte injury. In the present study, we sought to determine whether increased SOCE contributed to high glucose (HG)-induced podocyte injury through activation of the calpain pathway. In cultured human podocytes, whole-cell patch clamp indicated the presence of functional store-operated Ca<sup>2+</sup> channels, which are composed of Orai1 proteins and mediate SOCE. Western blots showed that HG treatment increased the protein abundance of Orai1 in a dose-dependent manner. Consistently, calcium imaging experiments revealed that SOCE was significantly enhanced in podocytes following HG treatment. Furthermore, HG treatment caused overt podocyte F-actin disorganization as well as a significant decrease in nephrin protein abundance, both of which are indications of podocyte injury. These podocyte injury responses were significantly blunted by both pharmacological inhibition of Orai1 using the small molecule inhibitor BTP2 or by genetic deletion of Orai1 using CRISPR-Cas9 lentivirus. Moreover, activation of SOCE by thapsigargin, an inhibitor of Ca<sup>2+</sup> pump on the endoplasmic/sarcoplasmic reticulum membrane, significantly increased the activity of calpain, which was inhibited by BTP2. Finally, the calpain-1/calpain-2 inhibitor calpeptin significantly blunted the nephrin protein reduction induced by HG treatment. Taken together, our results suggest that enhanced signaling via an Orai1/SOCE/Calpain axis contributes to HG-induced podocyte injury.
The Effect of Hyaluronan on Tendon Healing in Rabbits (2005)

Because hyaluronan treatment produces a clinical effect, even in only the early phase after ligament surgery, it could improve rehabilitation and produce a better outcome for ligament reconstruction.
The economics of academic health sciences libraries: cost recovery in the era of big science. (1988)

With launching of Sputnik by the Soviet Union in the late 1950s, science and technology became a high priority in the United States. During the two decades since, health sciences libraries have experienced changes in almost all aspects of their operations. Additionally, recent developments in medical care and in medical education have had major influences on the mission of health science libraries. In the unending struggle to keep up with new technologies and services, libraries have had to support increasing demands while they receive a decreasing share of the health care dollar. This paper explores the economic challenges faced by academic health sciences libraries and suggests measures for augmenting traditional sources of funding. The development of marketing efforts, institutional memberships, and fee-based services by the Louis Calder Memorial Library, University of Miami School of Medicine, is presented as a case study.
Modal analysis of a 50 μm core diameter photonic bandgap Bragg fiber operated at 1860 nm (2016)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text G. Granger, M. Jossent, M. Likhachev, M. Vögel, M. A. Ahmed, T. Graf, and S. Février, "Modal analysis of a 50 μm core diameter photonic bandgap Bragg fiber operated at 1860 nm," in Advanced Photonics 2016 (IPR, NOMA, Sensors, Networks, SPPCom, SOF), OSA Technical Digest (online) (Optica Publishing Group, 2016), paper SoM4G.3. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
A Study on CO<sub>2</sub>/CO Dual Sensor Module by NDIR Method (2011)

This research deals with the CO2/CO Dual Sensor Module measuring CO2 and CO, that is the representative environmental harmful material, simultaneously. In the measurement of the CO 2 and CO generally, the Non-Dispersive InfraRed method(NDIR method) is used for the precise measurement and durability. This method is to measure the concentration of the gas by using the Lambert-beer rule. When measuring the gas density with the NDIR method, the important factor is the apparatus for being called an optical chamber consisting of the emitter sensor and detector sensor are used for measuring concentration of the gas. Thus, this paper introduces an optical chamber of the new way of using the NDIR method and through this, shows an experimental result of the CO 2 gas concentration measurement and it presents possibility for measurement of the concentration of the CO.
Trends in Management and Outcomes among Patients with Urothelial Carcinoma Undergoing Radical Cystectomy from 1995 to 2015: The Memorial Sloan Kettering Experience (2020)

During a 21-year period outcomes after radical cystectomy at our institution improved significantly, as the probability of recurrence and cancer specific mortality decreased. Increasing use of neoadjuvant chemotherapy, rising pT0 rates, decreased positive soft tissue surgical margins and increasing lymph node yields likely contributed, suggesting that optimized surgical and perioperative care led to improved cancer outcomes in patients undergoing radical cystectomy.
A bayesian logistic regression model for active relevance feedback (2008)

Relevance feedback, which traditionally uses the terms in the relevant documents to enrich the user's initial query, is an effective method for improving retrieval performance. The traditional relevance feedback algorithms lead to overfitting because of the limited amount of training data and large term space. This paper introduces an online Bayesian logistic regression algorithm to incorporate relevance feedback information. The new approach addresses the overfitting problem by projecting the original feature space onto a more compact set which retains the necessary information. The new set of features consist of the original retrieval score, the distance to the relevant documents and the distance to non-relevant documents. To reduce the human evaluation effort in ascertaining relevance, we introduce a new active learning algorithm based on variance reduction to actively select documents for user evaluation. The new active learning algorithm aims to select feedback documents to reduce the model variance. The variance reduction approach leads to capturing relevance, diversity and uncertainty of the unlabeled documents in a principled manner. These are the critical factors of active learning indicated in previous literature. Experiments with several TREC datasets demonstrate the effectiveness of the proposed approach.
Low-coherence interferometric detection of photo-thermal and photo-acoustic effects in tissue (2003)

We have developed a low-coherence optical sensor for detection of laser-induced thermoelastic deformations in biological materials. The presented optical sensor utilizes a birefringent fiber-based dual channel low-coherence Michelson interferometer capable of differential phase measurements. We demonstrate that the low-coherence sensor can be used for spatially-resolved measurements of laser-induced thermoelastic deformations in biological materials with high axial resolution. Experimental studies were carried out using gelatin-based tissue phantoms.
Primary A (H1N1) pdm09 Influenza Pneumonia Diagnosed on Reverse Transcription-polymerase Chain Reaction (RT-PCR) of Bronchoalveolar Lavage Fluid but not Rapid Tests with Nasopharyngeal Swabs (2015)

A 47-year-old man with a fever was highly suspected of having influenza A infection since his wife and son who lived with him had been diagnosed with influenza A. Although repeated rapid tests with a nasopharyngeal swab showed negative findings, the patient developed bilateral pneumonia and reverse transcription polymerase chain reaction (PCR) for A (H1N1) pdm09 virus in the bronchoalveolar lavage fluid was positive. We therefore diagnosed him with primary influenza pneumonia and initiated treatment with peramivir plus corticosteroids, which rapidly improved his condition. During the influenza season, sample collection from the lower airway and PCR should be considered for the definitive diagnosis of primary influenza viral pneumonia.
Low-disparity binary coding system (1965)

The coding system described minimises the d.c. component in the transmitted binary signal by inverting characters when this will reduce the accumulated mark and space disparity. An added digit indicates when inversion has taken place. Conversion to and from unrestricted binary coding is relatively simple.
TLR-9 agonist CpG activates macrophages and modulates expression of microRNAs involved in cancer drug resistance and various signaling pathways (2022)

Abstract TLR-9 agonist, CpG induces pro-inflammatory immune response. We studied the immune response elicited in C57Bl/6 female mice by repeated stimulation of TLR-9 through multiple doses of CpG administration. Complete blood count analysis after CpG treatment revealed peripheral pancytopenia and the spleen showed splenomegaly. Flow cytometry analyses of spleen and liver mononuclear cells disclosed macrophage activation, evidenced by substantial increase in F4/80+ cells in the treatment group compared to control. Analysis of serum by ELISA demonstrated enhanced levels of pro-inflammatory cytokines, IL12/23, IL6 and TNFα in the CpG-treated group whereas no significant change was observed in the amount of anti-inflammatory cytokine, IL10. The spleen cells were further subjected to microarray analysis in order to examine the modulation of microRNA expression pattern following CpG treatment. Investigation of miRNA-mRNA relationships using the ingenuity pathway analysis (IPA) revealed differential expression of miRNAs associated with cancer drug resistance, HOTAIR and BAG signaling pathways along with microRNAs involved in immunomodulation. The major microRNAs altered with CpG treatment included mir27a, mir181, mir130a, mir487a, mir29b1, mir130a, mir3473b, mir21a, mir142 and mir144 targeting genes involved in drug resistance, apoptosis, cell cycle, angiogenesis and major histocompatibility complex-related proteins. Together, our studies demonstrate that chronic macrophage activation may lead to uncontrolled activation and proliferation of immune cells. (Supported by NIH grants P01AT003961, P20GM103641, R01AI129788, R01ES030144, R01AI160896 and R01AI123947). Supported by NIH grants P01AT003961, P20GM103641, R01AI129788, R01ES030144, R01AI160896 and R01AI123947
Note: Towards Community-Empowered Network Data Action (2022)

The Federal Communications Commission (FCC) has recently released official technical requirements for its Broadband Data Collection (BDC) processes, with the purpose of improving the accuracy of broadband coverage data in the United States. A key process in the BDC establishes the opportunity for communities to crowdsource Internet measurements that may dispute coverage data maintained by Internet service providers. This process outlines complex requirements that may provide a substantial barrier to community participation. In this poster we share the design of a network measurement tool suite and the requirements for a community coordination tool to support community-led efforts to challenge official reports. Our design is based on “counter-data action” principles, which call unethical and authoritative uses of data into question.
Thought and Action. (1961)

Journal Article Book Reviews Get access Thought and Action. By Stuart Hampshire. (London : Chatto & Windus. 1959. Pp. 276. Price 25s). Gershon Weiler Gershon Weiler Search for other works by this author on: Oxford Academic Google Scholar The Philosophical Quarterly, Volume 11, Issue 45, October 1961, Pages 381–382, https://doi.org/10.2307/2216548 Published: 01 October 1961
Procedures for Eliminating Static and Dynamic Hazards in Test Generation (1974)

One problem associated with test generation algorithms for sequential circuits is that they often produce tests which, when applied to the circuit under test, create static and/or dynamic hazards which may invalidate the test. Usually, for static hazards, but not dynamic hazards, these situations can be predicted using a logic simulator. In this paper we present procedures which can be added to path sensitization test generation algorithms so that the resulting procedure will not produce tests which will be invalidated due to hazards. Incidental to this work is a new simulation technique for handling both static and dynamic hazards. The principal concepts behind this work deal with detecting when hazards are created in a circuit; propagating hazard status information related to a signal line through a circuit; detecting those conditions at flip-flop inputs which necessitate hazard free conditions; and finally, selecting test inputs so that all hazard free conditions are satisfied.
Interhemispheric Subdural Electrodes (2013)

When clinical factors suggest the possibility of an epileptic focus at or near the midline, invasive monitoring of the paramedian cortex with interhemispheric grids can be safely used to define the epileptogenic zone and map local cortical function.