gebhart/patrepeval huggingface dataset:
Changes in coronary plaque component volumes comparing different virtual monoenergetic images using photon-counting computed tomography (2023)

Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): BV was supported by the ÚNKP-22-3-II-SE New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund. Introduction Photon-counting CT (PCCT) allows virtual monoenergetic images (VMIs) which may aid more precise assessment of coronary plaques. We aimed to analyze how plaque component volumes change on different VMIs. Methods Coronary CT angiography images were acquired using a dual-source PCCT and VMIs were reconstructed between 40–180 keV in 10 keV increments. Polychromatic images at 120 kVp (T3D) were also reconstructed and used as reference. Quantitative image quality analysis was performed on all reconstructed images. Quantitative plaque assessment was performed on T3D images and segmentation masks were copied to all VMI images. Calcified plaque (CP; &amp;gt;350 Hounsfield units, HU), non-calcified plaque (NCP; 30–350HU) and low-attenuation NCP (LAP; −100-30HU) volumes were calculated. Results We analyzed 51 plaques from 51 patients (67% male, mean age 65±12 years). Average attenuation and contrast-to-noise ratio (CNR) decreased significantly with increasing keV levels, with similar values observed between T3D and 70 keV images (299±209 vs 303±225 HU, p = 0.15 for mean HU; 15.5±3.7 vs. 15.8±3.5, p = 0.32 for CNR). Mean NCP volume was comparable between T3D and 100–180 keV reconstructions. There was a graded decrease in mean CP volume, with a significant difference between all VMI images and T3D (p&amp;lt;0.05). LAP volume increased with increasing VMI energy levels and all VMI images showed a significant difference compared to T3D, except for 50 keV (28.0±30.8 mm3 and 28.6±30.1 mm3, respectively, p = 0.63). Conclusion Fixed threshold settings result in significantly different plaque volumes when using VMIs as compared to T3D images. Normalization protocols are needed to have comparable results between future studies.
Estimation of the Influence of the Composition and Thickness of Catalytic Layers on Hydrogen Permeability of Tantalum Membranes (2021)

Increasing the service life and reducing the cost of inorganic hydrogen permeable selective membranes are important tasks of membrane technologies. To do this, it is necessary to create membranes in which the use of palladium will be minimized, providing high hydrogen permeability and stability, the required level of performance, and manufacturability. Here, the possibility of replacing palladium catalytic layers with layers of nickel and cobalt is considered using the example of symmetric tantalum membranes. The results of the influence of the composition and thickness of the catalytic layers on the hydrogen permeability of membranes and the period of their operation until destruction under test conditions at 580°С and a hydrogen pressure drop of 500–100 kPa are presented. It is shown that one of the reasons for the premature destruction of Pd/Ta/Pd membranes is oxidation, which develops at the catalytic layer/tantalum interface from the inlet side. The reasons for its occurrence under the conditions of membrane operation in an atmosphere containing corrosive gases are substantiated. Experimental results are presented, indicating that catalytic layers of nickel on the surface of membranes at a certain thickness ensure their high hydrogen permeability, stability of hydrogen flow, and duration of operation. This makes nickel a promising material to substitute for palladium in membranes for certain applications. Cobalt-based catalytic layers are unable to provide a high hydrogen permeability of membranes because of low catalytic activity during dissociative–associative hydrogen processes occurring on the membrane surface.
Identification of novel biomarkers in prostate cancer diagnosis and prognosis (2022)

Prostate cancer (PCa) is a common urinary malignancy. The lack of specific and sensitive biomarkers for the early diagnosis and prognosis of PCa makes it important to seek alternatives. R software was used to analyze the PCa expression profile from data sets in Gene Expression Omnibus. Core differential genes were identified by String and Cytoscape and further validated by Gene Expression Profiling Interactive Analysis (GEPIA) and The Human Protein Atlas (HPA). Gene Ontology analysis was done in the DIVID database and visualization analysis was conducted by Hiplot. Pathway enrichment was analyzed by IPA. To identify potential competitive endogenous RNAs (ceRNA) networks, the experimentally validated microRNA-target interactions database (miRTarBase), The Encyclopedia of RNA Interactomes (StarBase), lncBase, and GEPIA were used. The lncLocator was utilized to perform subcellular localization of long noncoding RNAs (lncRNAs). Both miRTarBase and StarBase were used to find the binding site of mRNAs-miRNAs and miRNAs-lncRNAs. Visualization of the ceRNA network was performed with Cytoscape. Nine genes closely related to the diagnosis and prognosis of PCa were obtained, including four identified biomarkers by HPA, CENPF, TPX2, TK1, and CCNB1, and five novel PCa biomarkers, RRM2, UBE2C, TOP2A, BIRC5, and ZWINT. Pathway analysis indicated that PCa carcinogenesis was highly correlated with liver fibrosis pathways, ILK signaling, and NRF2-mediated oxidative stress response. Two sets of ceRNA networks, BIRC5/hsa-miR-218-5p/NEAT1 and UBE2C/hsa-miR-483-3p/NEAT1 were found to be novel biomarkers for the identification of PCa. The quantitative real-time polymerase chain reaction results verified that UBE2C, BIRC5, and NEAT1 were upregulated and hsa-miR-218-5p and hsa-miR-483-3p were downregulated in human PCa cells compared with normal prostate epithelial cells. The novel identified biomarkers in this study would be valuable for the diagnosis and prognosis of PCa.
CAN NON-CHEMICAL ANTIMICROBIAL DEVICES REPLACE OR AUGMENT FUEL TREATMENT MICROBICIDES? (2011)

Despite their history of successful use as fuel system disinfectants and fuel preservatives, antimicrobial pesticide use faces increasing restrictions due to both regulatory control and public concerns. A variety of non-chemical treatments have been used with varying degrees of success to disinfect non-fuel fluids and to at least partially inhibit biofilm development on infrastructure surfaces. Promoters of one technology have claimed successful fuel disinfection and fuel-tank fouling prevention. This paper will review a range of non-chemical treatment technologies and will present the results of preliminary evaluations of several technologies that were tested on Jet A fuels that had been challenged with either Pseudomonas aeruginosa or Hormoconis resinae. Data are presented on treatment impact on adenosine triphosphate (ATP) concentration, culturability and live/dead direct counts in Jet A-1 and on glass microcosm surfaces.
Heterozygosity of Chaperone Grp78 Reduces Intestinal Stem Cell Regeneration Potential and Protects against Adenoma Formation (2018)

Deletion of endoplasmic reticulum resident chaperone Grp78 results in activation of the unfolded protein response and causes rapid depletion of the entire intestinal epithelium. Whether modest reduction of Grp78 may affect stem cell fate without compromising intestinal integrity remains unknown. Here, we employ a model of epithelial-specific, heterozygous <i>Grp78</i> deletion by use of <i>VillinCre<sup>ERT2</sup>-Rosa26<sup>ZsGreen/LacZ</sup>-Grp78<sup>+/fl</sup></i> mice and organoids. We examine models of irradiation and tumorigenesis, both <i>in vitro</i> and <i>in vivo</i> Although we observed no phenotypic changes in <i>Grp78</i> heterozygous mice, <i>Grp78</i> heterozygous organoid growth was markedly reduced. Irradiation of <i>Grp78</i> heterozygous mice resulted in less frequent regeneration of crypts compared with nonrecombined (wild-type) mice, exposing reduced capacity for self-renewal upon genotoxic insult. We crossed mice to <i>Apc</i>-mutant animals for adenoma studies and found that adenomagenesis in <i>Apc</i> heterozygous-<i>Grp78</i> heterozygous mice was reduced compared with <i>Apc</i> heterozygous controls (1.43 vs. 3.33; <i>P</i> < 0.01). In conclusion, epithelium-specific <i>Grp78</i> heterozygosity compromises epithelial fitness under conditions requiring expansive growth such as adenomagenesis or regeneration after γ-irradiation. These results suggest that Grp78 may be a therapeutic target in prevention of intestinal neoplasms without affecting normal tissue.<b>Significance:</b> Heterozygous disruption of chaperone protein Grp78 reduces tissue regeneration and expansive growth and protects from tumor formation without affecting intestinal homeostasis. <i>Cancer Res; 78(21); 6098-106. ©2018 AACR</i>.
Algorithmes STAP récursifs sur la distance pour radar aéroporté en configuration non latérale Range recursive STAP algorithms for airborne radar in non side looking configuration (2008)

and key words We address the problem of detecting slow moving target within ground clutter with a non side looking monostatic airborne radar using either a uniformly spaced and linear antenna (ULA) or a uniformly curved or circular antenna (UCuA and UCA respectively). To obtain the optimal STAP filter, the space time covariance matrix has to be inverted [1]. In practice, it is unknown and has to be estimated. With a monostatic radar using an ULA in side looking configuration, the clutter has specific properties : the space-time repartition of the clutter spectral power which is called “Clutter Ridge’’ is range independent. The space-time snapshots are thus iid and the classical SMI (Sample Matrix Inversion) estimator can be used [1]. But in case of a monostatic radar using an ULA in a non side looking configuration or using a UcuA or a UCA, the clutter properties are changed. The clutter ridges are range dependent and specific methods must be applied to compensate the range dependency [4], [5], [6]. But these methods are computational expensive and/or require the knowledge of the radar parameters. In this paper, we are rather interested in range-recursive subspace-based algorithms of linear computational cost. First, we establish the range dependency of the model of the clutter ridges
Identification of Novel Immunogenic Proteins from Mycoplasma bovis and Establishment of an Indirect ELISA Based on Recombinant E1 Beta Subunit of the Pyruvate Dehydrogenase Complex (2014)

The pathogen Mycoplasma bovis (M. bovis) is a major cause of respiratory disease, mastitis, and arthritis in cattle. Screening the key immunogenic proteins and updating rapid diagnostic techniques are necessary to the prevention and control of M. bovis infection. In this study, 19 highly immunogenic proteins from M. bovis strain PD were identified using 2-dimensional gel electrophoresis, immunoblotting and MALDI-TOF/TOF MS. Of these 19 proteins, pyruvate dehydrogenase E1 component beta subunit (PDHB) showed excellent immune reactivity and repeatability. PDHB was found to be conserved in different M. bovis isolates, as indicated by Western blot analysis. On the basis of these results, a rPDHB-based indirect ELISA (iELISA) was established for the detection of serum antibodies using prokaryotically expressed recombinant PDHB protein as the coating antigen. The specificity analysis result showed that rPDHB-based iELISA did not react with other pathogens assessed in our study except M. agalactiae (which infects sheep and goats). Moreover, 358 serum samples from several disease-affected cattle feedlots were tested using this iELISA system and a commercial kit, which gave positive rates of 50.8% and 39.9%, respectively. The estimated Kappa agreement coefficient between the two methods was 0.783. Notably, 39 positive serum samples that had been missed by the commercial kit were all found to be positive by Western blot analysis. The detection rate of rPDHB-based iELISA was significantly higher than that of the commercial kit at a serum dilution ratio of 1∶5120 to 1∶10,240 (P<0.05). Taken together, these results provide important information regarding the novel immunogenic proteins of M. bovis. The established rPDHB-based iELISA may be suitable for use as a new method of antibody detection in M. bovis.
IEEE PSS2B Versus PSS4B: The Limits of Performance of Modern Power System Stabilizers (2005)

IEEE Std 421.5 as revised by the IEEE excitation system subcommittee will introduce a new type of power system stabilizer model, the multiband power system stabilizers (PSSs). Although it requires two inputs, like the widely used IEEE PSS2B, an integral of accelerating power PSS introduced at the beginning of the nineties as the first practical implementation of a digital PSS, the underlying principle of the new IEEE PSS4B makes it sharply different. The present paper aims at assessing the two families of PSS's from the point of view of their relative performance in tackling a wide range of system problems, using a single set of so-called robust/universal settings. Conclusions are drawn from a large number of small- and large-signal analyzes performed on several test systems and on an actual Hydro-Que/spl acute/bec system, paying due account to the load models and governor response. Since either of the candidate PSSs can easily be tuned to perform acceptably in a standard local and/or inter-area oscillation scenario, emphasis will be put on comparing them at the inherent limits of the PSS concept, i.e., considering excessive VAR modulation during large generation rejection, fast load pickup on hydro units, and excessive torsional interactions during faults on large turbine-generators.
Is the Coronavirus Crisis Over? Gaps in Healthcare and Politics. (2020)

The coronavirus crisis we are suffering globally should soon be over. As of this writing (4/17/2020), there have been 150,000 deaths accounted for due to this cause and almost one million confirmed cases worldwide. Due to the lack of diagnostic testing and health politics to carry out analysis, mainly to those who are admitted to hospitals with symptoms, we still do not know the actual number of affected individuals, but it must be much higher than reported cases. The authors themselves have affected family members, even in Intensive Care Units (ICU). The healthcare and political authorities continue to say that the worst is yet to come. And certainly, very important, that we all stay at home. Once the national state of emergency is declared by governments, physical distancing compliance should be taken as an obligation for all.
The role of the dentate gyrus in the formation of contextual representations (2012)

The hippocampus is involved in encoding and integrating contextual information. Recently, it has been suggested that the dorsal dentate gyrus (dDG) hippocampal subregion may mediate the formation of contextual representations of the spatial environment through a conjunctive encoding process whereby incoming multimodal information is integrated into a single higher-order representation. Despite anatomical evidence in support of this claim, behavioral evidence is limited. Therefore, a contextual associative learning paradigm was used to determine whether the dDG supports the formation of integrated contextual representations. Male Long-Evans rats were randomly assigned as controls or to receive bilateral intracranial infusions of colchicine into the dDG. Following recovery from surgery, each rat was tested on an appetitive task that required animals to form an association between a cue (odor) and a context to receive a food reward. Each rat received 10 trials per day and was tested for 10 consecutive days. Upon completion of testing, animals were tested on an additional two-choice olfactory and contextual discrimination task. The testing order was counterbalanced across animals. Results showed that control animals successfully acquired the contextual associative learning task for olfactory stimuli as indicated by improved performance across the 10 testing days. In contrast, animals with dDG lesions were impaired in the ability to acquire the odor-context associations. Results from follow-up odor and context discrimination tests indicated that both groups acquired the discriminations at similar rates. Therefore, it is unlikely that deficits in performance on the contextual associative learning task were due to an inability to discriminate between odors or contexts. The present findings provide further support for DG involvement in the formation of conjunctive contextual representations.
Lipoxins A4 and B4 dilate cerebral arterioles of newborn pigs (1989)

We determined the effects of lipoxins A4 and B4 on the cerebral microcirculation of neonatal pigs and whether vascular responses were modulated by prostanoids. Pial arteriolar diameters were determined using a closed cranial window and intravital microscopy. Before lipoxin A4 application, arteriolar diameter was 143 +/- 6 microns (means +/- SE). Topical application of lipoxin A4 increased the diameter to 160 +/- 7 microns at 0.1 ng/ml, 167 +/- 7 microns at 1 ng/ml, and 173 +/- 7 microns at 10 ng/ml (n = 9). Before application of lipoxin B4, arteriolar diameter was 146 +/- 7 microns. Topical application of lipoxin B4 increased the diameter to 165 +/- 7, 169 +/- 6, and 175 +/- 6 microns at 0.1, 1, and 10 ng/ml (n = 9), respectively. Intravenous injection of indomethacin (5 mg/kg) or vehicle did not affect these responses. Levels of prostaglandins E2 and F2 alpha in cerebrospinal fluid (measured by radioimmunoassay) did not increase in response to lipoxins. We conclude that lipoxins are dilator stimuli in the cerebral circulation and that prostanoids do not mediate these responses.
Immunoglobulin A Vasculitis Associated With COVID-19 Infection Successfully Treated With Corticosteroid Regimen Without Relapse (2022)

Immunoglobulin A (IgA) vasculitis is an autoimmune disease associated with bacterial and viral infections that typically presents with palpable purpura, arthralgia, abdominal pain, and renal involvement. Coronavirus disease 2019 (COVID-19) infection has been found to trigger numerous autoimmune and rheumatologic conditions, including IgA vasculitis. We report a patient who had a COVID-19 infection and then two weeks later developed severe abdominal pain, nausea, emesis, diarrhea, hematochezia, palpable purpura, and arthralgia. Skin biopsy revealed deposition of IgA and C3 complement granular deposition with fibrinogen deposition in superficial dermal vessel walls consistent with IgA vasculitis. The patient was treated with intravenous methylprednisolone followed by oral prednisone with significant improvement and no relapse after tapering and discontinuing steroids in six weeks. This case of biopsy-proven IgA vasculitis precipitated by active COVID-19 infection demonstrates the ability of COVID-19 infection to induce IgA vasculitis and its response to corticosteroid treatment.
Discourse analysis and language teaching (1984)

Like other branches of linguistics language teaching has, until\nrecently, been concerned with grammatical rather than communicative competence. Wilkins observes that although there have been major changes in the methodology of language teaching over the years the underlying principle has remained the same: "it has been assumed that units of learning should be defined in grammatical terms, although the\nprecise sequence in which they occurred would be influenced by pedagogic considerations," (1972b). Further he suggests that even those courses which encourage dialogue and improvised drama are structured grammatically and the "situations that are created are pedagogic, bearing little resemblance to natural language use."
Differentiating low‐ and high‐grade pediatric brain tumors using a continuous‐time random‐walk diffusion model at high b‐values (2015)

With its sensitivity to intravoxel heterogeneity, the simplified CTRW model is useful for non-invasive grading of pediatric brain tumors, particularly when surgical biopsy is not feasible. Magn Reson Med 76:1149-1157, 2016. © 2015 Wiley Periodicals, Inc.
An iterative approach to build relevant ontology-aware data-driven models - application to food processes (2012)

In experimental Life Sciences, simulations are needed in order to extrapolate costly experiments and to design decision-support tools. When extensive mathematical knowledge is not available at the desired scale, expertise and data-driven models can be used as a basis for these simulations. We propose a generic iterative approach to design ontology-aware and relevant data-driven models. It is based upon an ontology to model the domain knowledge, and it uses decision trees as the learning method.
Development of through-hole contact(THC) integrated-type a-Si solar cell submodules. Fabrication of THC structure using lasers processing. (1991)

This paper presents a laser patterning technique which was developed for a high power solar cell with a through-Hole contact (THC), a new type structure.
Optimal siting and sizing of distributed energy storage systems via alternating direction method of multipliers (2014)

Energy Storage Systems (ESSs) has an important role in Active Distribution Networks (ADNs). Within this context this paper focuses on the problem of ESSs optimal siting and sizing. Following similar approaches already proposed by the Authors, this paper uses a multi-objective procedure to account various ancillary services that can be provided by ESSs. The proposed procedure takes into account the voltage support and network losses minimization along with minimization of the cost of energy from external grid. For the case of large-scale problems, accounting networks with large number of nodes and scenarios, the selection of the solution methodology is a non-trivial problem. In this respect, the paper proposes and discusses the applicability of the Alternative Direction Method of Multipliers in order to provide an efficient algorithm for large-scale networks that also provide a solution to the optimality aspect. A real large-scale network with real profiles of load and distributed photovoltaic generation is used as the case study to analyze the effectiveness of the proposed methodology.
A novel method of making PVF porous foam without using the pore forming agent (2014)

ABSTRACT Different with the conventional method of manufacturing poly(vinyl formal) (PVF) porous foam by using the pore‐forming agents such as wheat or potato starches, a novel method without using the pore‐forming agent is introduced in this article. Through the help of images taken by a scanning electron microscope, the formation process of the present PVF foam will be discussed in terms of the spinodal decomposition (SD) phase separation principle. Additionally, the effect of poly(vinyl alcohol) concentration and reaction temperature on the pore structure of the PVF foam will be investigated. Moreover, the water adsorption capacities of the PVF foams obtained by the present method will be studied in details through the analyses of pore‐size distribution, mechanical modulus, and thermal property. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132 , 41270.