gebhart/patrepeval huggingface dataset:
Ectopic Thyroid Tissue: Immunohistochemistry and Molecular Analysis (2017)

Ectopic thyroid tissue is rare and controversial. Some experts consider it to always be metastatic thyroid carcinoma, whereas others consider it benign as long as it is restricted to few follicles without cytoarchitectural features of papillary thyroid carcinoma. Immunohistochemistry (IHC) and molecular studies have not yet been performed to further characterize this entity. We retrospectively searched our pathology files for all ectopic thyroid inclusions and reviewed clinicopathologic characteristics and concurrent thyroid pathologic findings. We identified 8 cases from 7 patients. Ectopic thyroid tissue was present in the following locations: neck soft tissue: 3, thymus: 2, neck lymph nodes: 2, perihilar soft tissue: 1. All patients had histologically benign thyroid specimens. BRAFV600E (VE1) IHC, HBME-1 IHC, galectin-3 IHC, BRAFV600E allele-specific polymerase chain reaction (PCR) and NRAS/KRAS pyrosequencing were performed. To assess the sensitivity and specificity of BRAFV600E IHC compared with PCR; we tested 13 cases of primary and metastatic papillary and follicular thyroid carcinomas. All the ectopic cases were HBME-1, galectin-3, BRAFV600E (IHC, PCR), and NRAS/KRAS mutation negative (specificity=100%). Compared with PCR, BRAF IHC had 89% sensitivity and 100% specificity. Lack of common carcinoma-associated mutations supports benign nature of this entity. BRAF, HBME-1, and galectin-3 IHC are accurate and helpful when not enough tissue is available for molecular studies. IHC and molecular studies are more helpful than morphology alone in identifying benign thyroid rests.
Automated structure function object mapping (2018)

Imposing a step change in power dissipation to a packaged semiconductor and measurement of the resulting thermal response of a temperature sensitive parameter in time is a well-established testing method. This thermal response can be processed so as to derive a structure function, a representation of the thermal resistances and thermal capacitances the heat experiences as it travels from source to ambient. Identification of the objects through which the heat passes can be inferred by visual inspection of the changing gradients of the structure function. The thermal resistance and capacitance of those objects can thus be observed. Such visual inspection requires some level of experience. This study presents an automated approach to map the objects in the heat flow path to sections of the structure function utilizing a 3D thermal simulation of the measured device under test.
Effects of Oolong Tea on Gene Expression of Gluconeogenic Enzymes in the Mouse Liver and in Rat Hepatoma H4IIE Cells (2011)

Tea has many beneficial effects. We have previously reported that green tea and a catechin-rich green tea beverage modulated the gene expression of the gluconeogenic enzymes glucose-6-phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK) in the normal murine liver. In the present study, we examined the effects of oral administration of oolong tea on the hepatic expression of gluconeogenesis-related genes in the mouse. The intake of oolong tea for 4 weeks reduced the hepatic expression of G6Pase and PEPCK together with that of the transcription factor hepatocyte nuclear factor (HNF) 4α. When rat hepatoma H4IIE cells were incubated in the presence of oolong tea, the expression of these genes was repressed in accordance with the findings in vivo. The reduced protein expression of PEPCK and HNF4α was also demonstrated. We then fractionated oolong tea by sequential extraction with three organic solvents to give three fractions and the residual fraction (Fraction IV). In addition to organic fractions, Fraction IV, which was devoid of low-molecular-weight catechins such as (-)-epigallocatechin gallate (EGCG), had effects similar to those of oolong tea on H4IIE cells. Fraction IV repressed the gene expression of insulin-like growth factor binding protein 1, as insulin did. This activity was different from that of EGCG. The present findings suggest that drinking oolong tea may help to prevent diabetes and that oolong tea contains a component or components with insulin-like activity distinguishable from EGCG. Identification of such component(s) may open the way to developing a new drug for diabetes.
GaAs concentrator solar cell (1975)

For terrestrial applications, the figure of merit for photovoltaic solar energy conversion devices is watts output per dollar of cost. AlGaAs/GaAs heterojunction cells have a very favorable watts per dollar figure of merit when used at high values of sunlight concentration. An experimental 1/2−in.−diam cell was operated in air mass 1.4 sunlight with an output power density of 4.52 W/cm2 at an effective concentration of 312 suns with a power conversion efficiency of 17.5%. The same cell was operated at 200 °C with an output power density of 3.45 W/cm2 at a 14% efficiency. The efficiency of the cell was 23% with a fill factor of 0.85 at a lower concentration ratio which is obtainable using simple concentrator schemes.
Reply (1995)

Journal Article Reply Get access C. D. Marsden, C. D. Marsden 1University Department of Clinical Neurology, Institute of Neurology, The National Hospital for Neurology and NeurosurgeryLondon, UK Correspondence to: Professor C. D. Marsden, University Department of Clinical Neurology, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London WCIN 3BG, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar J. A. Obeso J. A. Obeso 2Centro de Neurologia y Neurocirugia FuncionalClinica Quiron San Sebastien, Spain Search for other works by this author on: Oxford Academic PubMed Google Scholar Brain, Volume 118, Issue 6, December 1995, Pages 1615–1617, https://doi.org/10.1093/brain/118.6.1615 Published: 01 December 1995
Comparison of deep levels in GaN grown by MBE, MOCVD, and HVPE (2005)

Deep levels in n-type GaN grown by molecular beam epitaxy, metalorganic chemical vapor deposition, and hydride vapor phase epitaxy were characterized for comparison between the different methods of growth. The deep level energies, capture cross sections, and concentrations were determined for each using deep level transient spectroscopy on Schottky diodes from 80 K to 700 K, to characterize traps up to ~1.2 eV. The capture kinetics and bias dependence were also measured for the main traps in each, in order to determine if they are related to threading dislocations, and if they are donor-type traps. Several traps were detected in samples from each growth method. The field dependence and the capture kinetics were not the same for peaks appearing in the same temperature in deep level spectra, associated with different growth method. Traps in HVPE GaN at 0.212 eV and 0.612 eV uniquely showed field dependence indicating singly charged donors. Overall, the thick hydride vapor phase epitaxy GaN samples showed the lowest concentration of traps.
Inspiring Reading Success: Interest and Motivation in an Age of High-Stakes Testing. (2007)

Although recent U.S. legislation has had a profound impact on reading instruction and student achievement, some students continue to fall behind. This provocative text addresses this gap with a new perspective on reading instruction that goes beyond the realms of teacher content knowledge and methodology. You'll learn how motivation and interest can enhance reading instruction for all students - and you'll get strategies to increase reading success.
Increased Immunolocalization of Paraoxonase, Clusterin, and Apolipoprotein A-I in the Human Artery Wall With the Progression of Atherosclerosis (1997)

Using immunolocalization techniques, we have shown that paraoxonase (Pon), clusterin, and apolipoprotein (apo) A-I accumulate in the artery wall during the development of atherosclerosis. In normal aortas (n = 6) there were low levels of extracellular Pon, clusterin, and apoA-I, immunoreactivity. The cytoplasm of smooth muscle cells in the media showed granular positivity for both Pon and apoA-I, indicating that these proteins were undergoing lysosomal degradation. This activity was also indicated by the presence of both intact and degradation products of Pon in smooth muscle cells as shown by Western blotting. With the progression of disease from fatty streaks (n = 3) to advanced atherosclerosis (n = 8) there was an increase in Pon, apoA-I, and clusterin immunoreactivity, indicating the increasing presence of these proteins with disease progression. These proteins are the components of a specific HDL subspecies that has been implicated in the prevention of peroxidative damage to phospholipids in LDL and membranes. The increase in Pon, clusterin, and apoA-I during the development of atherosclerosis may therefore represent a protective response to the oxidative stress associated with the development of atherosclerosis.
National Programme for Estonian Language Technology: a Pre-final Summary (2010)

The National Programme for Estonian Language Technology (2006&amp;ndash;2010) was launched in 2006 and is approaching to the end in 2010. This paper gives an overview of the programme and projects covering different areas of language technology; also the future prospects will be discussed.
P2A-1 Threshold Behavior of Vibrating Microbubbles (2006)

For individual phospholipid-coated microbubbles with a diameter smaller than 5 mum, highspeed camera recordings revealed threshold behavior in the onset of vibration. Previous studies showed a pressure-dependent attenuation for phospholipid-coated microbubbles. The aim of this study was to investigate if there is a relationship between microbubble threshold behavior and pressure-dependent attenuation. At a rising acoustic pressure from 5 to 200 kPa, the attenuation of BR14 increased linearly from 4.5 dB to 7 dB. In contrast to BR14, Levovist did not show pressure-dependent attenuation. For BR14 smaller than 3 mum diameter, attenuation increased from 4 to 12 dB. However, up to 50 kPa no increase of attenuation was observed. These observations can be explained by phospholipid-coated bubble threshold behavior. When the acoustic pressure increases above a threshold acoustic pressure, microbubbles smaller than 5 mum start to oscillate and contribute to the attenuation. Levovist is considered to be a free microbubble, for which threshold behavior is not expected. An imaging technique such as power modulation imaging could profit from the presence of an acoustic pressure threshold
IMS2018 Opening and Closing Sessions (2018)

Presents information on the IMA 2018 conference, including the opening and closing sessions.
ANALYSIS OF GREEN OPEN SPACE MANAGEMENT IN THREE PARKS IN KUPANG CITY (Case Study: Nostalgia Park, Ina Bo'i Park And Tirosa Park) (2023)

The purpose of this research is to know the role of government in the management of greenopen space in three city parks, knowing the implementation of Green Open Space governancein Three City Parks, knowing the benefits of green open space in three City Parks (NostalgiaPark, Ina Bo'I and Tirosa Park). This research was carried out in Nostalgia Park, Ina Bo'I Parkand Tirosa Park from October to November 2021 with a total of 384 respondents Datacollection techniques used in this study are interviews, questionnaires, documents and archives.From the data collected, a descriptive qualitative data analysis was carried out. The results ofthis study indicate that the management of green open spaces in three city parks by the KupangCity Environment and Hygiene Service describes four aspects, namely planning, organization,implementation and supervision. The implementation of Green Open Space governance in thethree city parks has several conceptual elaborations, namely, the location of the city park isadjusted to the direction of the RTRWK (City Spatial Planning) and still pays attention to thecity parks that already exist today. The activities developed are a combination of ecologicalinterests, family tourism and limited sports. The types of plants developed are prioritized ontypical/local plants and plants that have aesthetic value and shade plants. In terms of thebenefits of green open space for visitors, 24% of the community can gather with friends andfamily, 21% enjoy the scenery and refreshment, 15% reduce stress from work, 14% can getfresh air and can exercise and 12% enjoy the garden atmosphere.
Recent Progress and Application of Superconducting Nanowire Single-Photon Detectors (2017)

In this review, we present recent advances relating to superconducting nanowire single-photon detectors (SSPDs or SNSPDs) and their broad range of applications. During a period exceeding ten years, the system performance of SSPDs has been drastically improved, and lately excellent detection efficiencies have been realized in practical systems for a wide range of target photon wavelengths. Owing to their advantages such as high system detection efficiency, low dark count rate, and excellent timing jitter, SSPDs have found application in various research fields such as quantum information, quantum optics, optical communication, and also in the life sciences. We summarize the photon detection principle and the current performance status of practical SSPD systems. In addition, we introduce application examples in which SSPDs have been applied.
Isolation and characterization of murine alpha(1 going to 3)fucosyltransferase genes. (1995)

Murine $\alpha(1\to3$)fucosyltransferase genes provide the means to understand the function of $\alpha(1\to3$)fucosylated glycoconjugates during development and in the adult animal. Towards this end, we have isolated two murine genes which encode enzymes that participate in the synthesis of $\alpha(1\to3$)fucosylated oligosaccharides. Sequence comparisons, gene expression data, kinetic analyses, and chromosomal localization experiments indicate that one of these sequences is the murine homologue of the human Fuc-TIV gene. The murine Fuc-TIV gene is most highly expressed in bone marrow and the gastrointestinal tract, and, in transfected cells, encodes an enzyme which determines expression of cell surface Lewis$\rm\sp{X}$ but not sialyl Lewis$\rm\sp{X}$ epitopes. The second gene, referred to as Fuc-TVII, represents a novel sequence which differs from previously described $\alpha(1\to3$)fucosyltransferase sequences in genomic organization. The Fuc-TVII gene contains at least three exons which may be alternatively spliced to produce three different transcripts. The Fuc-TVII enzyme also has unique substrate specificities, catalyzing the construction of sialyl Lewis$\rm\sp{X}$ but not Lewis$\rm\sp{X}$ epitopes. In addition, Fuc-TVII expression is restricted primarily to myeloid tissues and cell lines, suggesting that Fuc-TVII enzyme constructs the ligands for E- and P-selectin. The Fuc-TVII gene has been localized to the proximal portion of mouse chromosome 2, which is syntenic with human chromosomes 9 and 10. Molecular data indicates that there is a human Fuc-TVII homologue. Anti-Fuc-TIV and anti-Fuc-TVII polyclonal antisera have been generated in rabbits using recombinant peptides synthesized in Escherichia coli. These antibodies were used to localize the Fuc-TIV and Fuc-TVII enzymes to the Golgi apparatus at the light microscopic level and may be used in future experiments to determine the subcellular localization of the proteins at the electron microscopic level. The anti-fucosyltransferase antibodies may also be used to investigate the biosynthesis of the Fuc-TIV and Fuc-TVII enzymes and define their expression patterns. We have begun isolating additional $\alpha(1\to3$)fucosyltransferase sequences in a variety of species using degenerate oligonucleotides and the polymerase chain reaction. We have isolated a human sequence from a HL60 cDNA library that has sequence similarity to the murine Fuc-TVII sequence. We have also isolated two distinct chicken genomic DNAs that exhibit sequence similarity to the human Fuc-TIII cDNA.
Automatic Multi-Organ Segmentation on Abdominal CT With Dense V-Networks (2018)

Automatic segmentation of abdominal anatomy on computed tomography (CT) images can support diagnosis, treatment planning, and treatment delivery workflows. Segmentation methods using statistical models and multi-atlas label fusion (MALF) require inter-subject image registrations, which are challenging for abdominal images, but alternative methods without registration have not yet achieved higher accuracy for most abdominal organs. We present a registration-free deep-learning-based segmentation algorithm for eight organs that are relevant for navigation in endoscopic pancreatic and biliary procedures, including the pancreas, the gastrointestinal tract (esophagus, stomach, and duodenum) and surrounding organs (liver, spleen, left kidney, and gallbladder). We directly compared the segmentation accuracy of the proposed method to the existing deep learning and MALF methods in a cross-validation on a multi-centre data set with 90 subjects. The proposed method yielded significantly higher Dice scores for all organs and lower mean absolute distances for most organs, including Dice scores of 0.78 versus 0.71, 0.74, and 0.74 for the pancreas, 0.90 versus 0.85, 0.87, and 0.83 for the stomach, and 0.76 versus 0.68, 0.69, and 0.66 for the esophagus. We conclude that the deep-learning-based segmentation represents a registration-free method for multi-organ abdominal CT segmentation whose accuracy can surpass current methods, potentially supporting image-guided navigation in gastrointestinal endoscopy procedures.
Nomogram to predict the number of oocytes retrieved in controlled ovarian stimulation (2016)

Our nomograms helped predict the number of oocytes retrieved in stimulated IVF cycles.
Tissue residue and comparative metabolism studies on tiazuril in the chicken, rat, dog, and monkey (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTissue residue and comparative metabolism studies on tiazuril in the chicken, rat, dog, and monkeyMartin J. Lynch and Sanford K. FigdorCite this: J. Agric. Food Chem. 1977, 25, 6, 1344–1353Publication Date (Print):November 1, 1977Publication History Published online1 May 2002Published inissue 1 November 1977https://doi.org/10.1021/jf60214a001Request reuse permissionsArticle Views27Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1003 KB) Get e-Alertsclose Get e-Alerts
Theoretical and experimental investigations of mercury adsorption on hematite surfaces (2017)

Atomic-scale theoretical simulations proposes that Hg physisorbs to the α-Fe<sub>2</sub>O<sub>3</sub>(0001) surface with an adsorption energy of -0.278 eV, and the subsequent Bader charge analysis confirms that Hg is slightly oxidized. In addition, Cl introduced to the Hg-adsorbed surface strengthens the Hg stability on the α-Fe<sub>2</sub>O<sub>3</sub>(0001) surface, as evidenced by a shortened Hg-surface equilibrium distance. The PDOS analysis also suggests that Cl enhances the chemical bonding between the surface and the adsorbate, thereby increasing the adsorption strength. Following laboratory-scale experiment of Hg sorption also shows that HgCl<sub>2</sub> physisorbs onto α-Fe<sub>2</sub>O<sub>3</sub> nanoparticles which have highly stepped structure.
Structural Changes during Uniaxial-Drawing and/or Heating of Poly(ethylene naphthalene-2,6dicarboxylate) Films (STATES AND STRUCTURE - Polymer Condensed States Analysis) (1995)

The structural changes in the uniaxial-drawing process of an un oriented amorphous film of poly(ethylene naphthalene-2,6-dicarboxylate) [PEN] and in the heating process of an oriented amorphous film of PEN were studied respectively using the heating/drawing device and the high-temperature furnace designed for the X-ray diffraction apparatus equipped with imaging plates.
Tailoring the morphology of PLA/PBAT/PA ternary blends (2013)

International audience
Transferring Microclusters of P. aeruginosa Biofilms to the Air–Liquid Interface of Bronchial Epithelial Cells for Repeated Deposition of Aerosolized Tobramycin (2021)

As an alternative to technically demanding and ethically debatable animal models, the use of organotypic and disease-relevant human cell culture models may improve the throughput, speed, and success rate for the translation of novel anti-infectives into the clinic. Besides bacterial killing, host cell viability and barrier function appear as relevant but seldomly measured readouts. Moreover, bacterial virulence factors and signaling molecules are typically not addressed in current cell culture models. Here, we describe a reproducible protocol for cultivating barrier-forming human bronchial epithelial cell monolayers on Transwell inserts and infecting them with microclusters of pre-grown mature <i>Pseudomonas aeruginosa</i> PAO1 biofilms under the air-liquid interface conditions. Bacterial growth and quorum sensing molecules were determined upon tobramycin treatment. The host cell response was simultaneously assessed through cell viability, epithelial barrier function, and cytokine release. By repeated deposition of aerosolized tobramycin after 1, 24, and 48 h, bacterial growth was controlled (reduction from 10 to 4 log<sub>10</sub> CFU/mL), which leads to epithelial cell survival for up to 72 h. E-cadherin's cell-cell adhesion protein expression was preserved with the consecutive treatment, and quorum sensing molecules were reduced. However, the bacteria could not be eradicated and epithelial barrier function was impaired, similar to the currently observed situation in the clinic in lack of more efficient anti-infective therapies. Such a human-based <i>in vitro</i> approach has the potential for the preclinical development of novel anti-infectives and nanoscale delivery systems for oral inhalation.
Study of the oligoester maleinates containing an isocyanuric ring by infrared spectroscopy (1971)

Abstract Processes taking place in crosslinked oligoester maleinates containing an isocyanuric ring were studied by means of infrared and ESR spectroscopy and heating from 110° to 600°C. By determining the optical density of the carbonyl groups at 1690 cm −1 , of the CH 2  groups at 1460 cm −1 , ether and ester groups at 1120 and 1260 cm −1 , and vinyl groups at 935 and 990 cm −1 , their mutation by hardening and tempering of the polymers was followed. The investigation shows that the carbonyl absorption of the oligoester maleinates containing an isocyanuric ring is double and that of the oligoester propylene‐glycol maleinate phthalate is single. By modification of the isocyanuric oligoester maleinates with phthalic, adipic, sebacic, and other acids, and increase of the speed of isomerization of maleric groupings to fumaric is observed. By building of isocyanuric links in oligoester maleinates, a more stable structure is obtained. Above 330°C, isocyanuric links probably regroup into polycyanic links. The typical carbonyl absorption precipitously decreases at 400°C and disappears altogether at 600°C. On the basis of the investigations carried out, it is assumed that, in the process of hardening and thermodestruction of the polymers investigated, and radical processes obviously play an essential part