gebhart/patrepeval huggingface dataset:
Abstract 3111A: ADCT-401/MEDI3726, a novel pyrrolobenzodiazepine (PBD)-based antibody-drug conjugate (ADC) targeting PSMA-expressing prostate cancers (2017)

Abstract Prostate-specific membrane antigen (PSMA) is an attractive target for an ADC approach as it is over-expressed by virtually all prostate cancers and its expression is highest in poorly-differentiated, metastatic and castration-resistant cases. PSMA has limited expression in non-prostatic tissues, it is not secreted or cleaved by PSMA-expressing cells, and it is constitutively internalized, a process that may be accelerated by specific antibody binding. ADCT-401/MEDI3726 is an ADC composed of a monoclonal antibody (J591), directed against human PSMA, site-specifically conjugated (drug-to-antibody ratio of 1.8) to a highly cytotoxic DNA cross-linking PBD dimer with a valine-alanine dipeptide linker. In vitro, ADCT-401/MEDI3726 demonstrated potent and specific cytotoxicity in a panel of PSMA-expressing prostate cancer cell lines, whereas its activity was greatly reduced in PSMA-negative cell lines. In vivo, ADCT-401/MEDI3726 showed strong antitumor activity against CWR22Rv1 and LNCaP human-derived prostate cancer xenograft models. In the CWR22Rv1 model, a tumor with low, heterogeneous PSMA expression, ADCT-401/MEDI3726 achieved dose-dependent antitumor activity when administered as single dose at either 0.33 or 1 mg/kg, which resulted in significant increase in survival compared to the vehicle-treated animals. Moreover, a single dose of ADCT-401/MEDI3726 showed remarkable superior antitumor activity compared to multiple doses of another PSMA-targeted ADC stochastically conjugated to the auristatin payload vcMMAE with a DAR of ~4. In the LNCaP model, ADCT-401/MEDI3726 resulted in dose-dependent antitumor activity when dosed once at 0.11, 0.33 or 1 mg/kg. In the PSMA-negative prostate cancer-derived PC3 xenograft model, ADCT-401/MEDI3726 and an isotope-control ADC showed limited tumor growth inhibition highlighting target-mediated antitumor activity. ADCT-401/MEDI3726 demonstrated potent and specific in vitro and in vivo antitumor activity in prostate cancer-derived models of differing levels of PSMA and this warrants further development of this ADC into the clinic. Citation Format: Francesca Zammarchi, Simon Chivers, Karin Havenith, David G. Williams, Lauren Adams, Maria Mellinas-Gomez, Simon Corbett, Peter Tyrer, Francois D'Hooge, Song Cho, Nazzareno Dimasi, Mary Jane Hinrichs, Phil W. Howard, John A. Hartley, Patrick H. van Berkel. ADCT-401/MEDI3726, a novel pyrrolobenzodiazepine (PBD)-based antibody-drug conjugate (ADC) targeting PSMA-expressing prostate cancers [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 3111A. doi:10.1158/1538-7445.AM2017-3111A
Whiteness Change During Heating and Cooling of Mozzarella Cheese (2000)

Whiteness (L-value) changes in low-fat and low-moisture, part-skim Mozzarella cheeses during heating (7 to 60 degrees C) and cooling (60 to 7 degrees C) were evaluated. In low-fat Mozzarella, a large increase in whiteness was observed during heating, and a decrease in whiteness was observed during cooling. In low-moisture, part-skim Mozzarella, the whiteness changes during heating and cooling were smaller. Serum phase was removed from low-fat and low-moisture, part-skim Mozzarella cheeses. White protein gels were formed when the isolated serum phase from either low-fat or low-moisture, part-skim Mozzarella was heated. The white gel that formed was composed predominantly of casein and casein proteolysis products. The gel might have been produced by heat-induced, hydrophobic protein-protein interactions, and it tended to dissociate when cooled. Formation of a gel during heating increased light scattering, which increased the L-value. The gel dissociated during cooling and no longer scattered light, which decreased the L-value. We hypothesized that a gel, which was reversible, formed in the serum phase of cheese during heating and might have been responsible for the observed changes in the L-value of low-fat Mozzarella cheese during heating and cooling. The additional fat in low-moisture, part-skim Mozzarella compared with low-fat Mozzarella masked some of the color changes in the serum phase of low-moisture, part-skim Mozzarella. A model was developed to describe the contributions of the casein matrix plus serum phase of Mozzarella cheese and the contribution of fat to the changes in whiteness of Mozzarella cheese during heating and cooling.
Analysis of the interaction site for the self superantigen Mls-1a on T cell receptor V beta. (1991)

Superantigen bound to major histocompatibility complex (MHC) products have been shown to stimulate T cells in a V beta-specific manner. Mouse T cells bearing V beta 8.1 usually respond to the self superantigen, Mls-1a, whereas T cells bearing V beta 8.2a do not. Previously, using site-directed mutational analysis, we identified the residues of natural variants of T cell receptor (TCR) V beta 8.2 that conferred Mls-1a reactivity. These residues are predicted to lie on a beta-pleated sheet of the TCR V beta element, well away from the expected binding site for antigen and MHC proteins. This study was undertaken to determine the effect of glycosylation on this beta-pleated sheet on Mls-1a reactivity and to map the extent of the interaction site on V beta 8.2 for Mls-1a. to Mls-1a, as well as to peptides derived from the conventional protein antigen, chicken ovalbumin. Here we demonstrate that first, N-linked carbohydrate on the lateral surface of V beta blocks the interaction of the TCR V beta with the self superantigen, Mls-1a, but has no effect on the TCR interaction with peptide antigen and MHC, second, that the interaction site for Mls-1a extends over the surface of the solvent-exposed beta-pleated sheet on the side of the TCR, and third, that mutations which affect both superantigen and peptide antigen reactivity lie at the beginning of the first complementarity determining region of V beta, consistent with models of the trimolecular complex of TCR-peptide-MHC.
Effects of carbendazim on <em>In vitro</em> micropropagation and flowering of pepper elder herbal plant (2019)

Tropical Agricultural Research and Extension is a peer-reviewed international scientific journal covering a wide range of subject areas in tropical and subtropical agriculture published quarterly by the Faculty of Agriculture, University of Ruhuna, Sri Lanka. The journal is also available on the Faculty of Agriculture, University of Ruhuna website https://www.agri.ruh.ac.lk/tare/index.htm .
A new affinity labeling reagent for the active site of glycogen synthase. Uridine diphosphopyridoxal. (1985)

A new affinity labeling reagent for glycogen synthase a from rabbit muscle, uridine diphosphopyridoxal, has been prepared. Incubation of the enzyme with this reagent resulted in a time-dependent, almost complete loss of activity. The inactivation was pseudo-first order, and the results of the kinetic analysis suggested the formation of a noncovalent enzyme-reagent complex prior to the covalent reaction, with a Kinact of 25 microM and a maximal rate constant of 0.22 min-1. The inactivation was pronouncedly protected by UDP-Glc and UDP, but not by the allosteric activator glucose 6-phosphate. The increase in a spectral peak at 425 nm and the decrease in enzymatic activity were well correlated, suggesting that the reagent causes the inactivation of the enzyme by the formation of a Schiff base. The rate of inactivation increased as the pH was raised, giving a pK of 8.85. Almost all the original activity was recovered by the treatment of the inactivated enzyme with cysteamine or any other aminothiol compound. No recovery of the activity, however, was observed with inactivated enzyme which had been treated with NaBH4. A peptide containing the labeled amino acid was isolated for inactivated enzyme after reduction with NaBH4, carboxymethylation, and chymotryptic digestion by fractionation on a Bio-Gel P-6 column and high performance liquid chromatographies. Manual Edman degradation established the sequence as Glu-Val-Ala-Asn-labeled Lys-Val-Gly-Gly-Ile-(Tyr). The introduction of an active site-directing moiety to pyridoxal 5'-phosphate makes the resultant reagent an effective probe for the active site of glycogen synthase.
Aging Does Not Lessen the Effectiveness of TGFβ2-Enhanced Bone Regeneration (2003)

Controversy exists over the potency of bone healing in the aged skeleton, and there is concern that enhancement of bone regeneration after use of bone-stimulating growth factors may not be effective in the aged. In this study, 30 skeletally mature beagles (1-2 or 10-12 years old) had titanium implants placed bilaterally in the proximal humerus for a period of 4 weeks in a model of intramembranous bone regeneration. A bony defect made at the time of surgery created a 3-mm gap between the implant surface and the host bone. Some of the implants were treated with recombinant human TGFbeta2 (rhTGFbeta2) at various does (0.32-35 microg per implant), and some served as paired controls. The dose response was similar in young and old animals. The most effective dose, 35 microg, led to a 3-fold increase in the volume fraction of new bone within the gap in both the young (p = 0.001) and old (p = 0.002) animals. At this dose, there was a 5-fold increase in osteoblast surface. While age did not significantly affect the quantity of new bone formed as assessed by backscatter scanning electron microscopy, the older animals had thinner regenerated trabeculae that tended to be spaced more closely than the younger animals. Coupled with the finding that the increase in osteoid was greater in the old animals compared with the young animals, these qualitative differences suggest that there may have been a slight delay in the rate or a defect of mineralization in the old animals.
Polymer/carbon nanotube composite patterns via laser induced forward transfer (2010)

Direct and high spatial resolution printing of polymer/carbon nanotube (CNT) composite layers has been demonstrated by means of laser induced forward transfer (LIFT). Laser irradiation of composite target materials, such as poly(acrylic acid)/CNT and polyvinylpyrrolidone/CNT, enabled dry deposition of well resolved composite pixels onto glass substrates. The dispersion of the CNT into the deposited composite pixels was investigated by transmission electron microscopy. The LIFT technique was also employed for the accurate deposition of polymer/CNT composite pixels onto aluminum microelectrodes for the fabrication of chemical sensors based on polymer/CNT compounds.
Superparamagnetic Microspheres with Controlled Macroporosity Generated in Microfluidic Devices (2012)

A microfluidic approach to preparing superparamagnetic microspheres with tunable porosity is described. In this method, droplets consisting of iron oxide nanoparticles, a functional polymer and solvent are formed in a microfluidic channel. The droplets are subsequently collected in solutions of sodium dodecyl sulfate (SDS) where the solvent is left to diffuse out of the droplet phase. By adjusting the concentration of the SDS and the polarity of the solvent of the dispersed phase, the porosity of the microparticles is controlled from non porous to porous structure. The formation of the pores is shown to depend on the rate at which solvent diffuses out of the droplet phase and the availability of SDS to adsorb at the droplet interface.
Worldsheet: Wrapping the World in a 3D Sheet for View Synthesis from a Single Image (2020)

We present Worldsheet, a method for novel view synthesis using just a single RGB image as input. The main insight is that simply shrink-wrapping a planar mesh sheet onto the input image, consistent with the learned intermediate depth, captures underlying geometry sufficient to generate photorealistic unseen views with large viewpoint changes. To operationalize this, we propose a novel differentiable texture sampler that allows our wrapped mesh sheet to be textured and rendered differentiably into an image from a target viewpoint. Our approach is category-agnostic, end-to-end trainable without using any 3D supervision, and requires a single image at test time. We also explore a simple extension by stacking multiple layers of Worldsheets to better handle occlusions. Worldsheet consistently outperforms prior state-of-the-art methods on single-image view synthesis across several datasets. Furthermore, this simple idea captures novel views surprisingly well on a wide range of high-resolution in-the-wild images, converting them into navigable 3D pop-ups. Video results and code are available at https://worldsheet.github.io.
The Ageing Process of Alkali Activated Metakaolin (2010)

This chapter contains sections titled: Introduction Experimental Results and Discussion Conclusion
Berechnungen für einen Verbundwerkstoff (1979)

Verbundwerkstoffe werden zur Erhöhung der Einsatztemperatur, zur Herabsetzung des Gewichts und z.B. zur Verbesserung der elektrischen und/oder thermischen Leitfähigkeit verwendet. In dieser Untersuchung werden Berechnungen für einen faserverstärkten Verbundwerkstoff durchgeführt, bei dem die Festigkeit einer Aluminium-Matrix durch einen Faserwerkstoff aus Bor erhöht wird.
ChemInform Abstract: CATIONIC Π‐ALLYLIC COMPLEXES. II. CATIONIC Π‐ALLYLIC COMPLEXES OF NICKEL(II) FROM ALLYLOXYTRIS(DIMETHYLAMINO)PHOSPHONIUM SALTS (1977)

Abstract Darstellung und Charakterisierung der Allyloxyphosphonium‐Salze (IV) und der luftstabilen ionischen Komplexe (VI) werden ausführlich beschrieben, wobei die Reaktion zu (VIa) hinsichtlich Zeit, Temperatur und Lösungsmittel optimiert wird.
Pressure Dependence of Uveoscleral Outflow (2002)

Department of Ophthalmology and Visual Sciences Washington University School of Medicine St. Louis, Missouri
Establishing Validity of the Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V) (2011)

Although both CAPE-V and GRBAS reliability coefficients varied across raters and parameters, this study reports slightly improved rater reliability using the CAPE-V to make perceptual judgments of voice quality in comparison to the GRBAS scale. The results provide evidence for the empirical (concurrent) validity of the CAPE-V.
Data-plane probe for in-band telemetry collection (2016)

Detecting and isolating network faults in IP networks has
traditionally been done using tools like ping and traceroute (see
[RFC7276]) or more complex systems built on similar concepts of active
probing and path tracing. While using active synthetic probes is
proven to be helpful in detecting data-plane faults, isolating fault
location is a much harder problem, especially in diverse networks with
multiple active forwarding planes (e.g. IP and MPLS). Moreover,
existing end-to-end tools do not generally support functionality
beyond dealing with packet loss - for example, they are hardly useful
for detecting and reporting transient (i.e. milli- or even micro-
second) network congestion. Modern network forwarding hardware can
allow for more sophisticated data-plane functionality that provides
substantial improvement to the isolation and identification
capabilities of network elements. For example, it has become possible
to encode a snapshot of a network element's state within the packet
payload as it transits the device. One example of such state would be
queue depth on the egress port taken by that specific packet. When
combined with a unique device identifier embedded in the same packet,
this could allow for precise time and topological identification of
the the congested location within the network. This document proposes
a format for requesting and embedding telemetry information in active
probes, i.e. packet designated for actively testing the network while
not carrying application traffic. These active probes could be
conveyed over multiple protocols (ICMP, UDP, TCP, etc.) and the
document does not prescribe any particular transport. In addition,
this document provides recommendations on handling the active probes
by devices that do not support the required data-plane functionality.
Suitability of the Coralline Alga Clathromorphum compactum as an Arctic Archive for Past Sea Ice Cover (2021)

Abstract Arctic sea ice cover has been steeply declining since the onset of satellite observations in the late 1970s. However, the available annually resolved sea ice data before this time are limited. Here, we evaluated the suitability of annual trace element (Mg/Ca) ratios and growth increments from the long‐lived annual increment‐forming benthic coralline red alga, Clathromorphum compactum, as high‐resolution sea ice cover archive. It has previously been shown that the growth of C. compactum is strongly light controlled and therefore greatly limited during the polar night and underneath sea ice cover. We compare algal data from 11 sites collected throughout the Canadian Arctic, Greenland, and Svalbard, with satellite sea ice data. Our results suggested that algal growth anomalies most often produced better correlations to sea ice concentration than Mg/Ca ratios or when averaging growth and Mg/Ca anomalies. High Arctic regions with persistently higher sea ice concentrations and shorter ice‐free seasons showed the strongest correlations between algal growth anomalies and satellite sea ice concentration over the study period (1979–2015). At sites where ice breakup took place before the return of sufficient solar irradiance, algal growth was most strongly tied to a combination of solar irradiance and other factors such as temperature, suspended sediments, phytoplankton blooms, and cloud cover. These data are the only annually resolved in situ marine proxy data known to date and are of utmost importance to gain a better understanding of the sea ice system and to project future sea ice conditions.
High-Resolution X-ray Spectroscopy Close to Room Temperature (1998)

: Originally designed as position-sensitive detectors for particle tracking, silicon drift detectors (SDDs) are now used for high-count rate X-ray spectroscopy, operating close to room temperature. Their low-capacitance read-node concept places them among the fastest high-resolution detector systems. They have been used in a new spectrum of experiments in the wide field of X-ray spectroscopy: fluorescent analysis, diffractometry, materials analysis, and synchrotron experiments such as X-ray holography and element imaging in scanning electron microscopes. The fact that the detector system can be used at room temperature with good spectroscopic performance and at -10 degrees C with excellent energy resolution, avoiding liquid nitrogen for cooling and high-quality vacuum, guarantees a large variety of new applications, independent of the laboratory environment. A brief description of the device principles is followed by basics on low noise amplification. The performance results of a complete detector system are presented as well as some dedicated applications already realized, including use in a surface mapping instrument and use of a "mini-spectrometer" for the analysis of works of art. Fully depleted pn-charge-coupled devices (pn-CCDs) have been fabricated for the European X-ray Multi-Mirror mission (XMM) and the German X-ray satellite ABRIXAS, enabling high-speed, low-noise, position-resolving X-ray spectroscopy. The detector was designed and fabricated with a homogeneously sensitive area of 36 cm2. At -70 degrees C it has a noise of 4 e- rms, with a readout time of the total focal plane array of 4 msec. The maximum count rate for single photon counting was 10(5) cps under flat field conditions. In the integration mode, more than 10(9) cps can be detected at 6 keV. Its position resolution is on the order of 100 µm. The quantum efficiency is higher than 90%, ranging from carbon K X-rays (277 eV) up to 10 keV.
Involvement of Sulfhydryl Groups in the Activity Regulation of α Type Phospholipase D (2000)

Conference Abstract| October 01 2000 Involvement of Sulfhydryl Groups in the Activity Regulation of α Type Phospholipase D T. Roh; T. Roh 1School of Chemistry and Molecular Engineering, Seoul National University, Seoul 151–142, Korea Search for other works by this author on: This Site PubMed Google Scholar I. Hwang; I. Hwang 1School of Chemistry and Molecular Engineering, Seoul National University, Seoul 151–142, Korea Search for other works by this author on: This Site PubMed Google Scholar J. H. Kim; J. H. Kim 1School of Chemistry and Molecular Engineering, Seoul National University, Seoul 151–142, Korea Search for other works by this author on: This Site PubMed Google Scholar M. Kim; M. Kim 1School of Chemistry and Molecular Engineering, Seoul National University, Seoul 151–142, Korea Search for other works by this author on: This Site PubMed Google Scholar K. S. Yoo; K. S. Yoo *Department of Chemistry, Duksung Women's University, Seoul 132–214, Korea Search for other works by this author on: This Site PubMed Google Scholar E. H. Koh; E. H. Koh *Department of Chemistry, Duksung Women's University, Seoul 132–214, Korea Search for other works by this author on: This Site PubMed Google Scholar M.-U. Choi M.-U. Choi 1School of Chemistry and Molecular Engineering, Seoul National University, Seoul 151–142, Korea Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (2000) 28 (5): A331. https://doi.org/10.1042/bst028a331a Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation T. Roh, I. Hwang, J. H. Kim, M. Kim, K. S. Yoo, E. H. Koh, M.-U. Choi; Involvement of Sulfhydryl Groups in the Activity Regulation of α Type Phospholipase D. Biochem Soc Trans 1 October 2000; 28 (5): A331. doi: https://doi.org/10.1042/bst028a331a Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 2000 Biochemical Society2000 Article PDF first page preview Close Modal You do not currently have access to this content.