gebhart/patrepeval huggingface dataset:
Evaluation of Variation in the Course of the Facial Nerve, Nerve Adhesion to Tumors, and Postoperative Facial Palsy in Acoustic Neuroma (2012)

Objective To investigate the variation in the course of the facial nerve (FN) in patients undergoing acoustic neuroma (AN) surgery, its adhesion to tumors, and the relationship between such adhesions and postoperative facial palsy. Methods The subjects were 356 patients who underwent AN surgery in whom the course of the FN could be confirmed. Patients were classified into six groups: ventro-central surface of the tumor (VCe), ventro-rostral (VR), ventro-caudal (VCa), rostral (R), caudal (C), and dorsal (D). Results The FN course was VCe in 185 cases, VR in 137, VCa in 19, R in 10, C in 4, and D in one. For tumors < 1.5 cm, VCe was most common. For tumors ≥ 1.5 cm, the proportion of VR increased. No significant difference was observed between the course patterns of the FN in terms of postoperative FN function, but for tumors > 3.0 cm, there was an increasing tendency for the FN to adhere strongly to the tumor capsule, and postoperative facial palsy was more severe in patients with stronger adhesions. Conclusions The VCe pattern was most common for small tumors. Strong or less strong adhesion to the tumor capsule was most strongly associated with postoperative FN palsy.
THYROID REGULATORY FUNCTION OF INTRA-OCULAR PITUITARY TRANSPLANTS1 (1961)

Thyroid regulatory responses to thyroxine administration and to hemithyroidectomy have been studied in hypophysectomized rats bearing intraocular pituitary transplants. The intra-ocular graft, though separated from direct contact with the hypothalamus stimulated thyroid I131 uptake but did not influence other measures of thyroid function (I131 release rate, thyroid weight, PBJ). The grafts released ACTH but had no effect on growth or on testicular weight. In the presence of the graft but not in ungrafted hypophysectomized animals hemi-thyroidectomy was followed by increased TSH release as evidenced by a more rapid I131 release rate, stimulation of I131 uptake and thyroid enlargement. Thyroxine injection led to thyroid inhibition both in pituitary graft-bearing hypophysectomized and in normal animals, but not in ungrafted hypophysectomized rats. These findings were taken to indicate that pituitary tissue is capable of appropriate and autonomous TSH secretory responses to alterations in blood thyroid hormone level. It was also shown that thyroxine treatment depresses thyroid function to a greater degree than does hypophysectomy. The low I131 release rate of hypophysectomized rats is not further reduced by thyroxine. In contrast, pituitary graft bearing hypophysectomized rats (whose resting thyroid release rate is the same as those animals without the pituitary graft) have a marked thyroid inhibitory response to thyroxine. Maximum decrease in thyroid function after thyroxine administration thus appears to require the presence of pituitary tissue.
Hepatic damage exacerbates cisplatin-induced acute kidney injury in Sprague-Dawley rats (2018)

The objective of this study was to elucidate the effect of hepatic damage on cisplatin (CDDP)-induced acute kidney injury (AKI). Thioacetamide (TAA, 150 mg/kg), a hepatotoxicant, was intraperitoneally (i.p.) injected to male Sprague-Dawley rats for 3 d prior to CDDP (5 mg/kg, i.p.) injection. All animals were sacrificed 5 d after CDDP treatment, and urine or blood was obtained to measure various parameters. No significant changes in serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity were observed after CDDP treatment. However, pretreatment with TAA significantly elevated ALT and AST activity. Serum blood urea nitrogen and creatinine levels significantly increased in CDDP-treated group compared to control. In addition, urinary excretion of novel protein-based biomarkers such as neutrophil gelatinase-associated lipocalin, vascular endothelial growth factor, kidney injury molecule-1, and tissue inhibitor of metalloproteinase-1 rose markedly in the CDDP-treated group. In particular, pretreatment with TAA markedly elevated CDDP-induced urinary excretion of protein-based nephrotoxic biomarkers compared with CDDP alone. Hematoxylin and eosin staining demonstrated that pretreatment with TAA following CDDP injection led to more severe tubular damage and apoptosis in rats compared with CDDP alone. Antioxidant status was significantly reduced in kidneys following pretreatment with TAA prior to CDDP. These findings indicate that liver injury enhanced the vulnerability of kidney to CDDP-induced AKI and this phenomenon may be associated with severe apoptotic damage.
Power-take-off control in a scaled experiment of a point absorber wave energy converter (2017)

This paper investigated the design of a power-take-off control system for the study of a model scaled point absorber wave energy converter in a wave flume experiment, where the scale of the experiment must be kept low to reduce the blockage effects of the buoy in the wave flume. In keeping the model small, the parasitic loss in the experimental set-up due to friction in the power-take-off was significant in comparison to the power absorption capability of the model scaled wave energy converter, and consequently, the power absorbed by the wave energy converter was significantly underestimated. To address this major limitation, a simple friction compensation algorithm was tested in the power-take-off control. Experimental results were benchmarked against those obtained from potential wave theory solvers for the understanding of the efficacy of the proposed method. It was evident that the proposed power-take-off control provided high fidelity results under both regular and irregular incident waves as long as the dynamic power-take-off control force was able to overcome the friction force in the experimental set-up.
Modélisation et simulation des performances de noeuds de routage optique dans les réseaux dorsaux hybrides (2004)

International audience
Not all Pseudomonas aeruginosa are equal: strains from industrial sources possess uniquely large multireplicon genomes (2019)

Pseudomonas aeruginosa is a highly versatile, antibiotic-resistant Gram-negative bacterium known for causing opportunistic infections and contamination of industrial products. Despite extensive genomic analysis of clinical P. aeruginosa strains, no genomes exist for preservative-tolerant industrial strains. A unique collection of 69 industrial isolates was assembled and compared to clinical and environmental strains; 16 genetically distinct industrial strains were subjected to array tube genotyping, multilocus sequence typing and whole-genome sequencing. The industrial strains possessed high preservative tolerance and were dispersed widely across P. aeruginosa as a species, but recurrence of strains from the same lineage within specific industrial products and locations was identified. The industrial P. aeruginosa genomes (mean=7.0 Mb) were significantly larger than those of previously sequenced environmental (mean=6.5 Mb; n=19) and clinical (mean=6.6 Mb; n=66) strains. Complete sequencing of the P. aeruginosa industrial strain RW109, which encoded the largest genome (7.75 Mb), revealed a multireplicon structure including a megaplasmid (555 265 bp) and large plasmid (151 612 bp). The RW109 megaplasmid represented an emerging plasmid family conserved in seven industrial and two clinical P. aeruginosa strains, and associated with extremely stress-resilient phenotypes, including antimicrobial resistance and solvent tolerance. Here, by defining the detailed phylogenomics of P. aeruginosa industrial strains, we show that they uniquely possess multireplicon, megaplasmid-bearing genomes, and significantly greater genomic content worthy of further study.
Laboratory-Confirmed Rotavirus Disease in Utah Children: Clinical and Economic Impact of Rotavirus Vaccination (2012)

Rotavirus vaccination in infants has dramatically decreased the clinical burden and direct medical costs of rotavirus gastroenteritis in both infants and young children.
Dual-wavelength fiber laser based on fine adjustment of cavity loss by a fiber optical loop mirror (2013)

We study experimentally the behavior of a dual wavelength Erbium doped fiber laser based on superimposed fiber Bragg gratings (SI-FBGs) and a loop mirror. The linear cavity is formed by a Hi-Bi Fiber Optical Loop Mirror (HBFOLM) and a SI-FBG. Three pairs of SI-FBGs were used to tune the dual wavelength laser at different wavelength ranges. The SIFBGs were placed on a mechanical mount that allow compression, both lines are shifted simultaneously. The separation of SI-FBGs is 5nm, and the set of three SI-FBGs permit to cover almost the entire spectrum of erbium from 1529nm to 1556nm approximately. The HBFOLM is used as a spectral tunable filter, which adjusts the losses by controlling the temperature in the Hi-Bi fiber, in order to stabilize the dual wavelength emission of the laser.
Olsenella faecalis sp. nov., an anaerobic actinobacterium isolated from human faeces (2019)

A novel actinobacterial strain, designated KGMB04489<sup>T</sup>, was isolated from the faeces of a healthy Korean. Cells of the strain were strictly anaerobic, Gram-stain-positive and short-rod-shaped. On the basis of 16S rRNA gene sequence similarity, strain KGMB04489<sup>T</sup> belonged to the genus Olsenella and was most closely related to Olsenella scatoligenes SK9K4<sup>T</sup> (94.3 %), Olsenella uli ATCC 49627<sup>T</sup> (93.5 %), Olsenella umbonata lac31<sup>T</sup> (93.4 %) and Olsenella profusa D315A-29<sup>T</sup> (93.3 %). The major end product was lactic acid. The DNA G+C content was 65.5 mol%. The major cellular fatty acids of strain KGMB04489<sup>T</sup> were C18 : 1cis9, C18 : 1cis9 DMA and C16 : 0. Strain KGMB04489<sup>T</sup> contained meso-diaminopimelic acid as the diamino acid in the peptidoglycan. The polar lipids consisted of an unidentified phospholipid, six unidentified glycolipids and an unidentified lipid. Based on phylogenetic, physiological and chemotaxonomic characteristics, strain KGMB04489<sup>T</sup> is considered to represent a novel species within the genus Olsenella, for which the name Olsenellafaecalis sp. nov. is proposed. The type strain is KGMB04489<sup>T</sup> (=KCTC 15699<sup>T</sup>=CCUG 72345<sup>T</sup>).
Two-Colored Fluorescence Correlation Spectroscopy Screening for LC3-P62 Interaction Inhibitors (2013)

The fluorescence correlation spectroscopy (FCS)-based competitive binding assay to screen for protein-protein interaction inhibitors is a highly sensitive method as compared with the fluorescent polarization assay used conventionally. However, the FCS assay identifies many false-positive compounds, which requires specifically designed orthogonal screenings. A two-colored application of the FCS-based screening was newly developed, and inhibitors of a protein-protein interaction, involving selective autophagy, were selected. We focused on the interaction of LC3 with the adaptor protein p62, because the interaction is crucial to degrade the specific target proteins recruited by p62. First, about 10,000 compounds were subjected to the FCS-based competitive assay using a TAMRA-labeled p62-derived probe, and 29 hit compounds were selected. Next, the obtained hits were evaluated by the second FCS assay, using an Alexa647-labeled p62-derived probe to remove the false-positive compounds, and six hit compounds inhibited the interaction. Finally, we tested all 29 compounds by surface plasmon resonance-based competitive binding assay to evaluate their inhibition of the LC3-p62 interaction and selected two inhibitors with IC50 values less than 2 µM. The two-colored FCS-based screening was shown to be effective to screen for protein-protein interaction inhibitors.
Electrochemical Polishing of Boron-Doped Diamond in Organic Media (2003)

The electropolishing of a B-doped diamond (BDD) film deposited by CVD was studied in HOAc-H2SO4 media. The electropolished surface was characterized by SEM, XPS, and electrochem. measurements. In 1 M H2SO4 no polishing of the surface occurred even after prolonged time; on the contrary, in electrolyte contg. 3 M HOAc in 1 M H2SO4 the morphol. changed rapidly. The surface became smoother and the roughness decreased as the typical results of a polishing process. All the nondiamond impurities were also removed by the electropolishing treatment in HOAc media. [on SciFinder (R)]
Thermotropic liquid-crystalline copolyesters containing substituted phenylene terephthalate and ethylene terephthalate units (1997)

Three series of aromatic, thermotropic copolyesters, based on terephthalic acid (TA), ethylene glycol (EG), and another diol were prepared. The third monomer was selected from three different hydroquinones including, ethoxyhydroquinone (EHQ), phenylhydroquinone (PHQ), and hydroquinone itself (HQ). The amounts of the different hydroquinone terephthalate units were varied while the amounts of ethylene terephthalate units remained constant. The copolymers and terpolymers were characterized for solubility, for morphology by polarized light microscopy (PLM), for molecular weight by solution viscometry, and by NMR, DSC, and TGA. At elevated temperatures all samples, when observed by PLM, displayed the characteristic texture of a nematic phase. The melting transition temperatures, Tm, were found to vary from 255 to 325°C, while the 5 wt % loss temperatures, Td, were found to vary from 330 to 440°C. The inherent viscosities varied from 0.6 to 1.9 dL/g. Increases in the HQ monomer content caused a decreased solubility and an increase in melting point. Copolymer compositions determined by NMR showed that only about one-half of the EG added was incorporated into the copolymers. © 1997 John Wiley & Sons, Inc.
Biogeochemical Evolution of a Landfill Leachate Plume, Norman, Oklahoma (2011)

Leachate from municipal landfills can create groundwater contaminant plumes that may last for decades to centuries. The fate of reactive contaminants in leachate-affected aquifers depends on the sustainability of biogeochemical processes affecting contaminant transport. Temporal variations in the configuration of redox zones downgradient from the Norman Landfill were studied for more than a decade. The leachate plume contained elevated concentrations of nonvolatile dissolved organic carbon (NVDOC) (up to 300 mg/L), methane (16 mg/L), ammonium (650 mg/L as N), iron (23 mg/L), chloride (1030 mg/L), and bicarbonate (4270 mg/L). Chemical and isotopic investigations along a 2D plume transect revealed consumption of solid and aqueous electron acceptors in the aquifer, depleting the natural attenuation capacity. Despite the relative recalcitrance of NVDOC to biodegradation, the center of the plume was depleted in sulfate, which reduces the long-term oxidation capacity of the leachate-affected aquifer. Ammonium and methane were attenuated in the aquifer relative to chloride by different processes: ammonium transport was retarded mainly by physical interaction with aquifer solids, whereas the methane plume was truncated largely by oxidation. Studies near plume boundaries revealed temporal variability in constituent concentrations related in part to hydrologic changes at various time scales. The upper boundary of the plume was a particularly active location where redox reactions responded to recharge events and seasonal water-table fluctuations. Accurately describing the biogeochemical processes that affect the transport of contaminants in this landfill-leachate-affected aquifer required understanding the aquifer's geologic and hydrodynamic framework.
Generation of a novel transgenic rat model for tracing extracellular vesicles in body fluids (2016)

Extracellular vesicles (EVs) play an important role in the transfer of biomolecules between cells. To elucidate the intercellular transfer fate of EVs in vivo, we generated a new transgenic (Tg) rat model using green fluorescent protein (GFP)-tagged human CD63. CD63 protein is highly enriched on EV membranes via trafficking into late endosomes and is often used as an EV marker. The new Tg rat line in which human CD63-GFP is under control of the CAG promoter exhibited high expression of GFP in various body tissues. Exogenous human CD63-GFP was detected on EVs isolated from three body fluids of the Tg rats: blood serum, breast milk and amniotic fluid. In vitro culture allowed transfer of serum-derived CD63-GFP EVs into recipient rat embryonic fibroblasts, where the EVs localized in endocytic organelles. These results suggested that this Tg rat model should provide significant information for understanding the intercellular transfer and/or mother-child transfer of EVs in vivo.
Spin-glass and non–spin-glass features of a geometrically frustrated magnet (1996)

We use neutron scattering to show that the low-temperature, short-range ordered spin configuration in the geometrically frustrated magnet SrCr9pGa12 − 9pO19 (p = 0.92(5)) is composed of small groups of spins whose dipole moments cancel. The local magnetic fluctuation spectrum, χ''(ω), vanishes approximately in proportion to ω for ℏω < 0.5 meV, distinguishing this magnet from conventional spin glasses which display a featureless continuum of excited states. We argue that this behavior results from the absence of local, low-energy excitations in the zero-spin clusters from which the frozen spin configuration is composed.
Proline‐Modified DNA as Catalyst of the Aldol Reaction (2007)

Unbound reactant: Proline-modified DNA acts as catalyst of the intramolecular aldol reaction between a complementary aldehyde and free non-tethered ketones (see scheme). The results of these studies extend the methodological repertoire of DNA-templated reactions.
High voltage automotive interface design, in a VLSI compatible BiCmos technology (2002)

With the increased levels of sophistication now being seen in modern cars, many auto manufacturers are investigating means by which they can reduce the complexity of the wiring harness in the average car. In order to achieve this they are developing interface standards to survive in the harsh automotive environment. In this paper we will talk about the design of an interface chip conforming to the VAN standard.
Interaction between Soluble P-Selectin and Soluble P-Selectin Glycoprotein Ligand 1:  Equilibrium Binding Analysis (1998)

Leukocyte rolling in the vasculature is mediated by the interaction of endothelial P-selectin and leukocyte P-selectin glycoprotein ligand 1 (PSGL-1). Since cell-cell interaction mediated by P-selectin and PSGL-1 is cooperative and complex, we have developed a model system to examine the binding of P-selectin to PSGL-1 in a soluble system. Equilibrium binding analyses were performed with truncated forms of soluble human P-selectin and dimeric PSGL-1, both lacking the transmembrane domain and both produced in Chinese hamster ovary (CHO) cells. Soluble PSGL-1 (sPSGL-1), which contains no tryptophan residues and exhibits no intrinsic fluorescence, was harvested from CHO cells cotransfected with either fucosyltransferase III (sPSGL-1/Fuc-TIII) or fucosyltransferase VII (sPSGL-1/Fuc-TVII). Both fucosylation isoforms of sPSGL-1 bound to sP-selectin. The interaction of sP-selectin and sPSGL-1 was studied by monitoring changes in the intrinsic fluorescence of sP-selectin upon binding to sPSGL-1. Binding of sPSGL-1 to sP-selectin in the presence of calcium caused an increase in tryptophan fluorescence that could be reversed by the addition of ethylenediaminetetraacetic acid (EDTA). The fluorescence enhancement of sP-selectin by sPSGL-1 was used to generate binding isotherms, and these data were fitted to a bimolecular binding model. The binding constant, Kd, for the binding of sPSGL-1/Fuc-TIII and sPSGL-1/Fuc-TVII to sP-selectin was 3 +/- 2 nM and 80 +/- 44 nM, respectively. Monomeric sP-selectin bound to dimeric sPSGL-1 with a 2:1 stoichiometry. In a system in which both protein species are soluble and lack transmembrane domains, these results indicate high-affinity interaction between P-selectin and PSGL-1. Furthermore, the fucosylation pattern of PSGL-1 can affect its affinity for P-selectin. These binding constants can be used to explore models of cell adhesion in flow systems.
Orthogonal variable spreading factor code selection for peak power reduction in multi-rate OFCDM systems (2004)

Orthogonal frequency and code division multiplexing (OFCDM) systems are expected for next generation wireless multi-rate communications. OFCDM can realize variable bit rates by using the variable spreading gain technique. However, this technique requires the code generator of the variable spreading factors and the transmitter is thus complex. The other drawback of OFCDM systems is that OFCDM signals have high peak-to-average power ratio (PAPR). Therefore, reducing the PAPR is required. In this paper, we propose a multi-rate OFCDM system that can realize two classes of data rates by the orthogonal variable spreading factor (OVSF) code, where the OVSF code generated by a single spreading factor code generator. The proposed multi-rate OFCDM can realize a high bit rate by dividing the spreading code and sending data in parallel with each of the divided OFCDM codes. The divided spreading code is selected to reduce the PAPR of the resultant OFCDM symbol. We show that in the proposed multi-rate OFCDM system, the high-rate users can achieve the better error rate performance than the users in multi-code multi-rate OFCDM system at the same bit rate. We also show that the low-rate users can achieve the same error rate performance as the users in the multi-code multi-rate OFCDM system.
Automatic enlargement of speech corpus for speaker recognition (2011)

This research deals with the problem of recognition when only a few samples are available for training of the system. To avoid the low recognition rate caused by such type of speech corpus, automatic techniques for the enlargement of speech corpus are proposed in this paper. These techniques are: lengthening of sample by automatic segmentation, automatic noise addition at different sound-to-noise ratios (SNRs), and lengthening of reversed sample. Different combinations of samples, generated by the proposed techniques, are used to obtain the high recognition rate. These techniques have shown promising result.
The Oxidation of the 2-Methyl Group of 3-Substituted 2-Methylindoles by Autoxidation and with Silver Acetate in Carboxylic Acids (1982)

Abstract The autoxidation of 3-alkyl-2-methylindoles in carboxylic acids, such as propionic acid and acetic acid, at the reflux temperature resulted in the selective oxidation of the 2-methyl group and the formation of 3-alkyl-2-formylindoles. The formation of the 2-formylindoles was dependent on the nature of the solvent used. The treatment of 3-benzoyl-1,2-dimethylindole with silver acetate gave 2-acetoxymethyl-3-benzoyl-1-methylindole and 3-benzoyl-2-formyl-1-methylindole. The mechanistic implications for the autoxidation and the oxidation with silver acetate are presented.