gebhart/patrepeval huggingface dataset:
Cyclodextrin Glucanotransferases (1991)

One of the challenges in the field of biotechnology is to learn how to design the catalytic activity of glucan biocatalysts to improve their stability, catalytic activity and product specificity. This overview presents recent developments in the area of cyclodextrin glucanotransferases (CGTase) and their product cyclodextrins (CD). A review of current CD/CGTase technology is presented, with extension to relate its importance on elucidating general glucosylase biocatalyst structural and functional relationships. A brief discussion of current research in genetic mutation of this class of biocatalysts to elucidate structural/functional features is also included.
Learning to Learn with Gaussian Processes (2021)

This paper presents Gaussian process meta-learning (GPML) for few-shot regression, which explicitly exploits the distance between regression problems/tasks using a novel task kernel. It contrasts sharply with the popular metric-based meta-learning approach which is based on the distance between data inputs or their embeddings in the few-shot learning literature. Apart from the superior predictive performance by capturing the diversity of different tasks, GPML offers a set of representative tasks that are useful for understanding the task distribution. We empirically demonstrate the performance and interpretability of GPML in several few-shot regression problems involving a multimodal task distribution and real-world datasets.
Data from Schedule-Dependent Synergy between the Heat Shock Protein 90 Inhibitor 17-(Dimethylaminoethylamino)-17-Demethoxygeldanamycin and Doxorubicin Restores Apoptosis to p53-Mutant Lymphoma Cell Lines (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose&lt;/b&gt;: Loss of p53 function impairs apoptosis induced by DNA-damaging agents used for cancer therapy. Here, we examined the effect of the heat shock protein 90 (HSP90) inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (DMAG) on doxorubicin-induced apoptosis in lymphoma. We aimed to establish the optimal schedule for administration of both drugs in combination and the molecular basis for their interaction.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Isogenic lymphoblastoid and nonisogenic lymphoma cell lines differing in p53 status were exposed to each drug or combination. Drug effects were examined using Annexin V, active caspase-3, cell cycle, and cytotoxicity assays. Synergy was evaluated by median effect/combination index. Protein expression and kinase inhibition provided insight into the molecular mechanisms of drug interaction.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Presence of mutant p53 conferred increased survival to single agents. Nevertheless, DMAG showed synergistic toxicity with doxorubicin independently of p53 status. Synergy required exposure to doxorubicin before DMAG. DMAG-mediated down-regulation of CHK1, a known HSP90 client, forced doxorubicin-treated cells into premature mitosis followed by apoptosis. A CHK1 inhibitor, SB-218078, reproduced the effect of DMAG. Administration of DMAG before doxorubicin resulted in G&lt;sub&gt;1&lt;/sub&gt;-S arrest and protection from apoptosis, leading to additive or antagonistic interactions that were exacerbated by p53 mutation.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Administration of DMAG to doxorubicin-primed cells induced premature mitosis and had a synergistic effect on apoptosis regardless of p53 status. These observations provide a rationale for prospective clinical trials and stress the need to consider schedule of exposure as a critical determinant of the overall response when DMAG is combined with chemotherapeutic agents for the treatment of patients with relapsed/refractory disease.&lt;/p&gt;&lt;/div&gt;
Using data mining to increase customer life time value (2006)

In the recent years, customer relationship management (CRM) is an important issue for marketers. Most of marketing researchers intend to compute customer value and provide valuable activities when customers demand are occurring. Unfortunately, the linkage between customer value and campaign management is still missing. This research proposes lifetime value (LTV) model in analyzing customer lifetime value to construct new promotion plans. To conduct a case study, this investigation extracts more than ten thousand customer data from a Nissan dealer for finding the customer detecion. From evaluating the customer lifetime values, we found two interesting outcomes. The first one is that the activities of maintenance item is more valuable than those activies of car purchasing and car issurance. The second one is that a lot of new customers lost their loyalties on the second year. To slove the two problems, this research suggest the studied Nissan dealer should take two corresponding promotion stratetgies. First, the dealer should provides five-years assurance for new car purchasing customers to increase their loyalty. Secondly, they need to decrease the price of maintenance and speed up the process of maintenance to attract customers.
Fresh frozen plasma resuscitation attenuates platelet dysfunction compared with normal saline in a large animal model of multisystem trauma (2014)

Resuscitation with FFP resulted in an immediate and sustained improvement in platelet function and clot strength compared with high-volume NS resuscitation. This was associated with an increase in fibrinogen levels and an attenuation of endothelial activation.
Evolutionary selection of pestivirus variants with altered or no microRNA dependency (2020)

Host microRNA (miRNA) dependency is a hallmark of the human pathogen hepatitis C virus (HCV) and was also described for the related pestiviruses, which are important livestock pathogens. The liver-specific miR-122 binds within the HCV 5' untranslated region (UTR), whereas the broadly expressed let-7 and miR-17 families bind two sites (S1 and S2, respectively) in the pestiviral 3' UTR. Here, we dissected the mechanism of miRNA dependency of the pestivirus bovine viral diarrhea virus (BVDV). Argonaute 2 (AGO2) and miR-17 binding were essential for viral replication, whereas let-7 binding was mainly required for full translational efficiency. Furthermore, using seed site randomized genomes and evolutionary selection experiments, we found that tropism could be redirected to different miRNAs. AGO cross-linking and immunoprecipitation (CLIP) experiments and miRNA antagonism demonstrated that these alternative variants bound and depended on the corresponding miRNAs. Interestingly, we also identified miRNA-independent variants that were obtained through acquisition of compensatory mutations near the genomic 3' terminus. Rescue experiments demonstrated that miRNA binding and 3' mutagenesis contribute to replication through mutually exclusive mechanisms. Altogether, our findings suggest that pestiviruses, although capable of miRNA-independent replication, took advantage of miRNAs as essential host factors, suggesting a favorable path during evolutionary adaptation.
Uncertainty modeling via frequency domain model validation (1999)

Abstract The majority of literature on robust control assumes that a design model is available and that the uncertainty model bounds the actual variations about the nominal model. However, methods for generating accurate design models have not received as much attention in the literature. The influence of the level of accuracy of the uncertainty model on closed loop performance has received even less attention. The research reported herein is an initial step in applying and extending the concept of model validation to the problem of obtaining practical uncertainty models for robust control analysis and design applications. An extension of model validation called 'sequential validation' is presented and applied to a simple spring-mass-damper system to establish the feasibility of the approach and demonstrate the benefits of the new developments.
Subunit III of Cytochrome c Oxidase Influences the Conformation of Subunits I and II: An Infrared Study (1995)

The secondary structure of wild-type Paracoccus denitrificans cytochrome c oxidase obtained by decomposition of the infrared amide I band contains 44% alpha-helix, 18% beta-sheet, 14% beta-turns, 18% loops, and 6% nonordered segments. The mutant lacking subunit III presents a small but significant increase (from 18% to 24%) in the percentage of loops and slight differences in the other components. Using band/area ratios and tyrosine side chain absorption as an inner standard, it is shown that in the absence of subunit III the structure of subunits I and II is altered although no changes in their alpha-helix or beta-sheet content are observed. In the bacterial oxidase, thermal infrared studies show a complex denaturation pattern characterized by the presence of a partially denatured intermediate state. Of the seven predicted subunit III alpha-helices, only four are resistant toward the thermal challenge and behave as expected for typical transmembrane helices. The observation that the absence of subunit III influences the conformation of loop regions in the two other subunits suggests that part of the interaction surface between subunit III and the catalytic subunits might be located outside the lipid bilayer.
The association of increased weight, body mass index, and tissue density with the risk of breast carcinoma in Vermont (2000)

Among postmenopausal Vermont women, weight, BMI, and breast density were independently associated with breast carcinoma risk. Because breast density and weight or BMI are inversely related, estimates of their independent effects should be used when evaluating a woman's risk for breast carcinoma.
Detection and Characterization of Tumor Changes in 18F-FDG PET Patient Monitoring Using Parametric Imaging (2011)

The PI method has been successfully applied to characterize early metabolic tumor changes in 78 lesions from (18)F-FDG PET/CT scans of patients with metastatic colorectal cancer during chemotherapy. The PI findings correlated well with the standard RECIST-based response assessment.
To the Islands – Photographs of Tropical Colonies in The Queenslander (2009)

Abstract Australian readers knew a great deal about the Pacific Islands in the early 20th century. This understanding came from missionary fund‐raising campaigns, visiting lantern‐slide lecturers, postcards and illustrated books and encyclopaedia but most of all, after the mid‐1890s, from heavily illustrated weekend newspapers. These were published in all major cities and offered a regular visual window on ‘the islands’, of which three were Australian colonies shortly after World War I. This paper argues that Australians were well‐informed about the potential for settlement, and commercial and economic opportunities. It notes that illustrated newspapers were dominated by ethnographic images of the material culture and lifestyles of island peoples, but that images of wharves, plantations, port towns and colonial infrastructure were provided for those readers who thought the western Pacific should become an Australian or at least a British sphere of interest. Ultimately The Queenslander’s editorial motivation was to alert Australian readers to the economic potential of plantations, trade, mining, travel and settling in the nearby tropics.
Roasted Coffee Reduces β‐Amyloid Production by Increasing Proteasomal β‐Secretase Degradation in Human Neuroblastoma SH‐SY5Y Cells (2018)

The data suggest that the roasting process may be crucial for the protective effects of coffee consumption in AD.
In vitro regeneration and bulblet growth from lily bulbscale explants as affected by retardants, sucrose and irradiance (2005)

Bulbscales of oriental lily hybrid Star Gazer were used as the explants. Bulblets were formed on the basal portion of the excised bulbscales on MS medium supplemented with growth retardants, different sucrose concentrations and exposed to continuous light or dark. Alar, Cycocel and Paclobutrazol in concentration 1 mg dm-3 produced higher number of bulblets as compared to the control. The number of bulblets, however, decreased with the increase in concentration of the growth retardants. The number of bulblets was higher at 90 than at 60 g dm-3 sucrose and when the bulbscales were exposed to continuous light than to darkness. The growth retardants, higher sucrose concentration and continuous dark stimulated fresh mass of bulblets. The number of bulblets having roots and leaves decreased in medium with Alar, Cycocel and Paclobutrazol as compared to the control. A few bulblets produced roots and leaves in medium with 90 g dm-3 sucrose and none of the regenerated bulblets produced leaves under continuous dark.
Acoustic Emission as Analyzing Tool for Wear Mechanisms of Composite Materials (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
The effect of tourniquet pressure on muscle function (1989)

The adverse effects of excessive tourniquet pressure on underlying muscle were studied using a cat model. A direct effect of the magnitude of tourniquet pressure on the degree of muscle disability was observed. The effect of direct pressure on the muscle may contribute to the postoperative weakness seen in the quadriceps muscle. Our data, in conjunction with the results of other studies that correlate certain tourniquet times and pressures with potential adverse effects, suggest that the selection of an appropriate tourniquet pressure and duration will minimize the development of clinically significant complications.
Arterial Stiffness: A New Cardiovascular Risk Factor? (1994)

Journal Article Arterial Stiffness: A New Cardiovascular Risk Factor? Get access Donna K. Arnett, Donna K. Arnett 1Department of Epidemiology, School of Public Health, University of North CarolinaChapel Hill, NC Reprint requests to Dr. Donna K. Amett, Department of Epidemiology, School of Public Health, CB #7400, McGavran-Greenberg Building, University of North Carolina, Chapel Hill, NC 27599-7400 Search for other works by this author on: Oxford Academic PubMed Google Scholar Gregory W. Evans, Gregory W. Evans 2Department of Public Health Sciences, Bowman-Gray School of MedicineWinston-Salem, NC Search for other works by this author on: Oxford Academic PubMed Google Scholar Ward A. Riley Ward A. Riley 3Departments of Neurology and Public Health Sciences, Bowman-Gray School of MedicineWinston-Salem, NC Search for other works by this author on: Oxford Academic PubMed Google Scholar American Journal of Epidemiology, Volume 140, Issue 8, 15 October 1994, Pages 669–682, https://doi.org/10.1093/oxfordjournals.aje.a117315 Published: 15 October 1994 Article history Received: 11 August 1993 Revision received: 19 May 1994 Published: 15 October 1994
Qi compliant wireless charger with PCB integrated magnetic material (2019)

Wireless power charging for mobile devices becomes more and more attractive, as the majority of the state-of-the-art devices offer this feature. Space sensitive applications often require ultra-low height of the charging station itself. In case of portable devices, it also needs to have less weight too. Greater number of all wireless charging stations cannot offer such feature. This paper describes a concept for ultra-thin wireless charging stations. Advanced printed circuit board design and manufacturing with PCB integrated nanocrystalline sheets helps to optimize the antenna circuit as well as the performance, while reducing the height and weight at the same time. To be comparable to standard devices available at the market, a Qi charging circuit on bottom side controls the antenna.
Die Darstellung isoleucinverwandter L‐α‐Aminocarbonsäuren (1975)

Abstract Isocyanessigsäure‐ tert ‐butylester ( 4 ) ist ein geeignetes Ausgangsprodukt, aliphatische α‐Amino‐carbonsäuren in wenigen Schritten und guten Ausbeuten darzustellen. Diese Arbeit beschreibt, ausgehend von 4 , die Synthese von β‐unverzweigten α‐Aminocarbonsäuren ( 6 ), die Darstellung von 3,3‐Dialkyl‐2‐formamido‐2‐alkensäureestern ( 7 ), deren Hydrierung und Verseifung zu β‐verzweigten α‐Aminocarbonsäuren ( 9 ), die enzymatische Trennung racemischer Gemische sowie die Trennung diastereomerer Aminosäuren durch Hochspannungspapierelektrophorese. Die Absolutkonfiguration der reinen Verbindungen wird mitgeteilt.
Stratigraphic Correlation of Well Logs by Computer Techniques (1973)

Stratigraphic correlation by computer of two geophysical logs involved the vertical shifting of one log relative to another until their characteristics were aligned as indicated by the maximum value of the cross correlation function. Correlation of logs with different thicknesses of strata was more complicated and involved a two-step process: (1) resampling the log at an expanded or stretched interval, and (2) using the stretched log to determine the vertical shifting necessary to align the common characteristics of two logs. Models simulating geophysical logs and geophysical logs of actual sites in Indiana were correlated in the form of computer plots of the logs. Correlation lines were drawn in the plots to connect equivalent units of strata in each log.
Comparison of Validity between WST-1 and MTT Test in Bioceramic Materials (2005)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Signed‐For Delivery in the Mitochondrial Matrix: Confirming Uptake into Mitochondria (2018)

Abstract Mitochondria are best known for their ability to provide energy in the form of an elevated ATP/ADP ratio to the cell via oxidative phosphorylation, and impairment of mitochondrial ATP production can lead to a variety of diseases. For many of these disorders, caused by mutations in the mtDNA, classical gene therapy or gene‐editing techniques are not possible due to the difficulty of importing nucleic acids into the mitochondrial matrix where the aberrant genes are transcribed. Technical progress in this field has been severely hampered by the inability to correctly determine whether uptake into the mitochondrial matrix of nucleic acids and related oligomers has occurred. Here, the methods that have been used to determine translocation of macromolecules into mitochondria in the past are described, and some recent developments in the field are discussed.
NeRF: Representing Scenes as Neural Radiance Fields for View Synthesis (2020)

We present a method that achieves state-of-the-art results for synthesizing novel views of complex scenes by optimizing an underlying continuous volumetric scene function using a sparse set of input views. Our algorithm represents a scene using a fully-connected (non-convolutional) deep network, whose input is a single continuous 5D coordinate (spatial location $(x,y,z)$ and viewing direction $(θ, ϕ)$) and whose output is the volume density and view-dependent emitted radiance at that spatial location. We synthesize views by querying 5D coordinates along camera rays and use classic volume rendering techniques to project the output colors and densities into an image. Because volume rendering is naturally differentiable, the only input required to optimize our representation is a set of images with known camera poses. We describe how to effectively optimize neural radiance fields to render photorealistic novel views of scenes with complicated geometry and appearance, and demonstrate results that outperform prior work on neural rendering and view synthesis. View synthesis results are best viewed as videos, so we urge readers to view our supplementary video for convincing comparisons.
Production of extreme high vacuum with non evaporable getters (1997)

Producing pressures lower than 10−12 Torr (XHV) at room temperature imposes severe constraints on the performance of materials and pumps. While today a wide choice of materials exists, only bakeable cryopumps and getter pumps are suitable for XHV applications. Non Evaporable Getter (NEG) pumps maintain their high pumping speed at the lowest pressures and therefore fulfil XHV requirements. The results presented here show that pressure in the low 10−13 Torr and low 10−14 Torr ranges have been obtained in two different set-ups with a Zr-Al and a Zr-V-Fe NEG respectively.
A Formal Verification Approach for Robotic Workflows (2021)

Formal verification is a powerful tool to show functional correctness of task and workflow descriptions representing robot-based manufacturing processes. A prerequisite is the integration of the process into a well-structured modeling and design architecture. In this paper, we propose a layer-based formal verification scheme that accepts BPMN-based input models. The integrated composition of tools enables state-space comprehensive verification targeting a set of user-defined verification goals. The importance of formal verification scheme is highlighted by our methodology which strictly supports a model refinement and abstraction approach. Since the complexity and size of robot application process models are steadily increasing this feature in combination with a clear verification methodology is a substantial contribution towards industrial acceptance.
Elemental composition of compact human bone correlated with the osteocyte network (2016)

Searchable abstracts of presentations at key conferences on calcified tissues ISSN 2052-1219 (online)
Allyloxy carbanions. New synthesis of aldehydes via a .beta.-acyl carbanion equivalent (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAllyloxy carbanions. New synthesis of aldehydes via a .beta.-acyl carbanion equivalentW. Clark Still and T. L. MacdonaldCite this: J. Am. Chem. Soc. 1974, 96, 17, 5561–5563Publication Date (Print):August 1, 1974Publication History Published online1 May 2002Published inissue 1 August 1974https://pubs.acs.org/doi/10.1021/ja00824a040https://doi.org/10.1021/ja00824a040research-articleACS PublicationsRequest reuse permissionsArticle Views548Altmetric-Citations156LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts