gebhart/patrepeval huggingface dataset:
Endoplasmic Reticulum Stress Is Important for the Manifestations of α-SynucleinopathyIn Vivo (2012)

Accumulation of misfolded α-synuclein (αS) is mechanistically linked to neurodegeneration in Parkinson's disease (PD) and other α-synucleinopathies. However, how αS causes neurodegeneration is unresolved. Because cellular accumulation of misfolded proteins can lead to endoplasmic reticulum stress/unfolded protein response (ERS/UPR), chronic ERS could contribute to neurodegeneration in α-synucleinopathy. Using the A53T mutant human αS transgenic (A53TαS Tg) mouse model of α-synucleinopathy, we show that disease onset in the αS Tg model is coincident with induction of ER chaperones in neurons exhibiting αS pathology. However, the neuronal ER chaperone induction was not accompanied by the activation of phospho-eIF2α, indicating that α-synucleinopathy is associated with abnormal UPR that could promote cell death. Induction of ERS/UPR was associated with increased levels of ER/microsomal (ER/M) associated αS monomers and aggregates. Significantly, human PD cases also exhibit higher relative levels of ER/M αS than the control cases. Moreover, αS interacts with ER chaperones and overexpression of αS sensitizes neuronal cells to ERS-induced toxicity, suggesting that αS may have direct impact on ER function. This view is supported by the presence of ERS-activated caspase-12 and the accumulation of ER-associated polyubiquitin. More important, treatment with Salubrinal, an anti-ERS compound, significantly attenuates disease manifestations in both the A53TαS Tg mouse model and the adeno-associated virus-transduced rat model of A53TαS-dependent dopaminergic neurodegeneration. Our data indicate that the accumulation αS within ER leads to chronic ER stress conditions that contribute to neurodegeneration in α-synucleinopathies. Attenuating chronic ERS could be an effective therapy for PD and other α-synucleinopathies.
On the use of DNA pooling to estimate haplotype frequencies (2002)

Abstract Genome‐wide association studies may be necessary to identify genes underlying certain complex diseases. Because such studies can be extremely expensive, DNA pooling has been introduced, as it may greatly reduce the genotyping burden. Parallel to DNA pooling developments, the importance of haplotypes in genetic studies has been amply demonstrated in the literature. However, DNA pooling of a large number of samples may lose haplotype information among tightly linked genetic markers. Here, we examine the cost‐effectiveness of DNA pooling in the estimation of haplotype frequencies from population data. When the maximum likelihood estimates of haplotype frequencies are obtained from pooled samples, we compare the overall cost of the study, including both DNA collection and marker genotyping, between the individual genotyping strategy and the DNA pooling strategy. We find that the DNA pooling of two individuals can be more cost‐effective than individual genotypings, especially when a large number of haplotype systems are studied. Genet Epidemiol 24:74–82, 2003. © 2003 Wiley‐Liss, Inc.
Tracing B-genome chromatin in Brassica napus × B. juncea interspecific progeny (2006)

We used polymerase chain reaction (PCR) and fluorescence in situ hybridization (FISH) techniques to demonstrate the presence of Brassica B-genome chromosomes and putative B-genome introgressions in B. napus x B. juncea interspecific progeny. The B-genome--specific repeat sequence pBNBH35 was used to generate PCR products and FISH probes. The highest frequencies of viable progeny were obtained when B. napus was the maternal parent of the interspecific hybrid and the first backcross. B-genome--positive PCR assays were found in 34/51 fertile F2 progeny (67%), which was more than double the proportion found in fertile BC(1) progeny. Four B-genome--positive F(2)-derived families and 1 BC(1)-derived family were fixed or segregating for B. juncea morphology in the F(4) and BC(1)S(2), respectively, but in only 2 of these families did B. juncea-type plants exhibit B. juncea chromosome count (2n = 36) and typical B-genome FISH signals on 16 chromosomes. The remaining B. juncea-type plants had B. napus chromosome count (2n = 38) and no B-genome FISH signals, except for 1 exceptional F(4)-derived line that exhibited isolated and weak B-genome FISH signals on 11 chromosomes and typical A-genome FISH signals. B. juncea morphology was associated with B-genome--positive PCR signals but not necessarily with 16 intact B-genome chromosomes as detected by FISH. B-genome chromosomes tend to be eliminated during selfing or backcrossing after crossing B. juncea with B. napus, and selection of lines containing B-genome chromatin during early generations would be promoted by use of this B-genome repetitive marker.
Control of cascaded H-bridge multilevel inverter with individual MPPT for grid-connected photovoltaic generators (2012)

A single-phase cascaded H-bridge multilevel inverter for a grid-connected photovoltaic (PV) system with nonactive power compensation is presented in this paper. To maximize the solar energy extraction of each PV string, an individual maximum power point tracking (MPPT) control scheme is applied, which allows the independent control of each dc-link voltage. A generalized nonactive power theory is applied to generate the nonactive current reference. Within the inverter's capability, the local consumption of nonactive power is provided to realize power factor correction. A single-phase modular cascaded multilevel inverter prototype has been built. Each H-bridge is connected to a 195 W solar panel. Simulation and experimental results are presented to validate the proposed ideas.
Decontamination of chemical warefare agent simulator Dimethyl Methylphosphonate (DMMP) using RF large area non-thermal atmospheric pressure plasma (2008)

Experimental results of the treatment of dimethyl methylphosphonate (DMMP), which is a chemical stimulant of the sarin gas, are reported. The plasma used for the experiment was a large area non-thermal RF atmospheric pressure plasma produced in the ambient air, of which size was 15times100 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . Previously measured current and gas temperature were low enough for thermally-sensitive material treatments, and actual applications to a pork sample and human skin proved its electrical and thermal safety. 100 muliter of the liquid DMMP was dropped on copper and glass plates then treated by the plasma at the input power of 100 W for several tens of minutes. Fourier transform infrared spectroscopy showed that several minute long treatment was enough to significantly affect the DMMP characteristic infrared spectrum. On the other hand, gas chromatography was used for quantitative measurements. The treated copper and glass plates were placed in methane chloride solvent to collect the remaining DMMP. Then, the DMMP concentration of each solution was measured. After 10 minutes of the treatment, 99.05% of DMMP on the copper plate was gone, and 99.96% DMMP on the glass plate was decontaminated after 16 minutes of the treatment. These decontamination rates are far good compared to other conventional methods such as heat, chemical catalyst etc.
Accelerated Aging of Fast Pyrolysis Bio-Oil Using Carbonyl Titration: Laboratory Analytical Procedure (LAP) (2021)

This laboratory analytical procedure covers the accelerated aging of fast pyrolysis bio-oils. Bio-oils undergo reactions that result in physical and chemical changes over time . These changes typically result in an increase in molecular weight, decrease in some functional groups such as carbonyls, and an increase in viscosity; additionally, the aging process often leads to phase separation. Studies have shown that accelerated aging of bio-oils using this method closely mimics room temperature aging for long periods of time (over 3 years). This procedure has been developed for the accelerated aging of fast pyrolysis bio-oils only. Fast pyrolysis bio-oils are more reactive than other bio-oils (e.g., catalytic fast pyrolysis) and undergo aging much more rapidly. Therefore, this procedure should only be used for fast pyrolysis bio-oil samples.
Reversible and irreversible electrical switching in TeO2-V2O5 based glasses (1992)

The switching phenomenon observed in electronically conductive glasses corresponds to a sudden decrease in electrical resistance of the sample when a large electric field is applied. A simple electrothermal model is developed which takes into account only a Joule effect overheating of the material. In a temperature range below the glass transition temperature, Tg, the switching is reversible. On the other hand, in a temperature range above Tg, a conductive crystalline phase is irreversibly formed leading to a permanent high conductivity state.
Redo sphincteroplasty: are the results sustainable? (2015)

Objective: This study aimed to investigate the long-term outcomes of patients who undergo redo sphincteroplasty (RS). Methods: Patients with fecal incontinence (FI) who underwent RS between November 1988 and December 2011 were retrospectively identified from a prospective database. A questionnaire and telephone survey assessed current Cleveland Clinic Fecal Incontinence Score (CCFFIS; best 0, worst 20) and Fecal Incontinence Quality of Life (FIQoL; best 4.1, worst 1) scale. Success was defined as no further continence surgery, no stoma and CCFFIS <9 at completion of follow-up. The Wilcoxon and Mann-Whitney U tests were used for comparing quantitative variables. Bivariate logistic regression analysis was done to identify predictive factors for success. Results: Fifty-six (66.7%) of 84 patients who underwent RS were available for evaluation at a median follow-up of 74 (range: 12-283) months. The mean CCFFIS decreased from 16.5 6 3.7 to 11.9 6 6.6 (P < 0.001) at last follow-up. Twelve patients (21.4%) underwent further continence surgery for failed sphincteroplasty, three (5.4%) of whom had a permanent stoma. Eighteen patients (32.1%) had a CCFFIS <9 at the completion of follow-up, and 16 (28.6%) had long-term success. Twentyfour patients evaluated for FIQoL had a mean value of 2.6 (range: 1.0-4.1). Postoperative CCFFIS was correlated with FIQoL (Spearman's correlation coefficient 0.854, P < 0.001). Logistic regression analysis did not reveal any significant predictive variables for success of RS. Conclusion: Based on our criteria for success, the long-term success rate for RS over a median of 74 months is poor.
Development of a test method for investigating moisture transfer rate of textiles (2018)

Moisture management textiles have proved to be one of the fastest growing sector in textiles. New research and development of these textiles have pushed the boundaries of textile testing equipment as new test methods are required. This paper will focus on the development of test method with potential application in testing and analyzing of textile fabrics which can be used in moisture management industry. A new system has been developed which allows fabrics moisture transmission to be tested whilst situated between two variable conditions mini chambers. The system allows moisture level to be monitored by precision weight scale and all the real-time data can be controlled and analyzed by computer.
SIMULATION AND CONTROL OF A QUADROTOR UNMANNED AERIAL VEHICLE (2011)

systems engineering approach to the design, development, testing and implementation of a quadrotor unmanned aerial vehicle. Many current research endeavors into the field of quadrotors for use as unmanned vehicles do not utilize the broad systems approach to design and implementation. These other projects use pre-fabricated quadrotor platforms and a series of external sensors in a mock environment that is unfeasible for real world use. The ANGEL system was designed specifically for use in a combat theater where robustness and ease of control are paramount. A complete simulation model of the ANGEL system dynamics was developed and used to tune a custom controller in MATLAB and Simulink®. This controller was then implemented in hardware and paired with the necessary subsystems to complete the ANGEL platform. Preliminary tests show successful operation of the craft, although more development is required before it is deployed in field. A custom high-level controller for the craft was written with the intention that troops should be able to send commands to the platform
Radar Estimation of Building Layouts Using Jump-Diffusion (2007)

Estimating buildings layouts using exterior radar measurements is a challenging task involving the electromagnetic modeling, many unknown parameters, and limited number of sensors. We propose using the jump-diffusion algorithm as a powerful stochastic tool that can be used to determine the number of walls, estimate their unknown positions and other parameters. We improve the convergence rate of the jump-diffusion algorithm by developing an iterative procedure that first finds low- resolution estimates, which are then used to initiate our more accurate estimation. Our efficient usage of the available frequency bandwidth, improves the computational speed that otherwise would be hampered by the forward electromagnetic modeling.
Micelles based on gold-glycopolymer complexes as new chemotherapy drug delivery agents (2012)

Polymeric versions of deacetylated auranofin, a gold complex with a sugar ligand, were prepared by post-modifying RAFT glycopolymers. Micellisation of a block copolymer containing pendant Au(I) units produced nanoparticles with an increased anti-proliferative effect against OVCAR-3 human ovarian carcinoma cells.
Emergence of robust 2D skyrmions in SrRuO3 ultrathin film without the capping layer (2018)

Magnetic skyrmions have fast evolved from a novelty, as a realization of topologically protected structure with particle-like character, into a promising platform for new types of magnetic storage. Significant engineering progress was achieved with the synthesis of compounds hosting room-temperature skyrmions in magnetic heterostructures, with the interfacial Dzyaloshinskii-Moriya interactions (DMI) conducive to the skyrmion formation. Here we report findings of ultrathin skyrmion formation in a few layers of SrRuO3 grown on SrTiO3 substrate without the heavy-metal capping layer. Measurement of the topological Hall effect (THE) reveals a robust stability of skyrmions in this platform, judging from the high value of the critical field 1.57 Tesla (T) at low temperature. THE survives as the field is tilted by as much as 85 degrees at 10 Kelvin, with the in-plane magnetic field reaching up to 6.5 T. Coherent Bragg Rod Analysis, or COBRA for short, on the same film proves the rumpling of the Ru-O plane to be the source of inversion symmetry breaking and DMI. First-principles calculations based on the structure obtained from COBRA find significant magnetic anisotropy in the SrRuO3 film to be the main source of skyrmion robustness. These features promise a few-layer SRO to be an important new platform for skyrmionics, without the necessity of introducing the capping layer to boost the spin-orbit coupling strength artificially.
Case study-MRI facility in hospital environment (2002)

Hospitals are equipped with the latest medical electronics to diagnose and perform complicated surgery. To fulfill the above, hospitals are equipped with various general utilities like air conditioning plants, DG sets, elevators, electrical power tools for maintenance, communication sets etc. These facilities are prone to create electromagnetic interference (EMI) which may affect the operation of sophisticated diagnostic tools. In addition, systems like MRI and X-rays can emit harmful EM and X-rays to inflict severe effects on an operator who performs duties continuously near the system. To install such facilities in hospital electromagnetic environments, a chamber with a good shielding capability with an attenuation of 80 dB or more is essential for the operation of the system. This paper outlines the need for such a shielded chamber for an MRI facility in the hospital EM environment and tests experience encountered while testing for the shielding effectiveness of the chamber. The test setup used in the measurement, problems observed and necessary corrective measures are discussed.
STUDY OF THE DISTRIBUTION OF THE SPACING AND THE REDUCED NEUTRON LENGTHS IN ENERGY LEVELS OF RHODIUM-104 OBTAINED BY THE INTERACTION OF SLOW NEUTRONS WITH RHODIUM-103 (1962)

The first results of the analysis of the total cross section of Rh/sup 103/ up to 370 ev gives a value of the density function S/sub 0/ = 0.5 plus or minus 0.1 x 10/sup -4/ and indicate that more than half the twenty-two resonances studied are caused by p waves. On the contrary the distribution of the spaces studied up to 800 ev is very close to the Wigner law for two populations. (tr-auth)
Minimal Sets of Distinct Literals for a Logically Passive Function (1971)

A method is presented for determining minimal sets of distinct literals for a logically passive function, i.e. one which can be implemented, using only AND and OR gates. The first step in the procedure is the determination of vacuous variables by an examination of the truth table. The resulting table is then expanded to include one column for each variable and the complement of each variable. Columns are examined to determine which ones can be deleted and yet leave the function logically passive.
Chapitre 3. La naissance d’un habitat urbain durant le ive s (2003)

3.1 Vestiges d’habitat et rejets de boucherie dans la palestre des thermes (phase 7) Durant la période de troubles de la fin du iiie s., certaines villes semblent avoir concentré les activités autour des centres monumentaux, en se dotant le plus souvent d’un rempart. À Paris, les différents plans de synthèse réalisés à partir de l’étude des nécropoles (fig. 58) attestent un resserrement du tissu urbain du sud au nord entre le forum et la Seine et d’est en ouest du théâtre de la rue Racine aux...
Clinicopathological characteristics and long‐term outcomes of plasmablastic lymphoma in British Columbia (2022)

Summary Plasmablastic lymphoma (PBL) is an aggressive and rare subtype of non‐Hodgkin lymphoma with no standard‐of‐care therapy. We reviewed all patients diagnosed with histologically confirmed PBL in British Columbia, Canada between 1997 and 2019. Overall, 42 patients were identified, including 15 (36%) positive for HIV and nine (21%) on chronic immunosuppression. Curative‐intent treatment consisting primarily of cyclophosphamide, doxorubicin, vincristine and prednisone was administered to 31 patients, of which 74% achieved response, however 61% relapsed after a median of 7.5 months. At a median follow‐up of eight years for the whole cohort, five‐year progression‐free survival (PFS) and overall survival (OS) were 18% [95% confidence interval (CI): 6%, 30%] and 22% (95% CI: 8%, 36%) with median eight and 15 months respectively. There were no differences in relapse rate ( p = 0.962), PFS ( p = 0.228) or OS ( p = 0.340) according to immune status. For those treated with curative intent, five‐year PFS and OS were 24% (95% CI: 8%, 40%) and 31% (95% CI: 13%, 49%) with median 18 and 27 months respectively. In this population‐based cohort of PBL patients spanning 20 years, survival outcomes were poor. Ultimately, further research is needed to develop more effective treatment strategies and to improve survival for patients.
Inhaled milrinone in cardiac surgical patients: pharmacokinetic and pharmacodynamic exploration (2023)

Mean arterial pressure to mean pulmonary arterial pressure ratio (mAP/mPAP) has been identified as a strong predictor of perioperative complications in cardiac surgery. We therefore investigated the pharmacokinetic/pharmacodynamic (PK/PD) relationship of inhaled milrinone in these patients using this ratio (R) as a PD marker. Following approval by the ethics and research committee and informed consent, we performed the following experiment. Before initiation of cardiopulmonary bypass in 28 pulmonary hypertensive patients scheduled for cardiac surgery, milrinone (5 mg) was nebulized, plasma concentrations measured (up to 10 h) and compartmental PK analysis carried out. Baseline (R<sub>0</sub>) and peak (R<sub>max</sub>) ratios as well as magnitude of peak response (∆<sub>Rmax-R0</sub>) were measured. During inhalation, individual area under effect-time (AUEC) and plasma concentration-time (AUC) curves were correlated. Potential relationships between PD markers and difficult separation from bypass (DSB) were explored. In this study, we observed that milrinone peak concentrations (41-189 ng ml<sup>-1</sup>) and Δ<sub>Rmax-R0</sub> (- 0.12-1.5) were obtained at the end of inhalation (10-30 min). Mean PK parameters agreed with intravenous milrinone published data after correction for the estimated inhaled dose. Paired comparisons yielded a statistically significant increase between R<sub>0</sub> and R<sub>max</sub> (mean difference, 0.58: 95% CI 0.43-0.73; P < 0.001). Individual AUEC correlated with AUC (r = 0.3890, r<sup>2</sup> = 0.1513; P = 0.045); significance increased after exclusion of non-responders (r = 4787, r<sup>2</sup> = 0.2292; P = 0.024). Individual AUEC correlated with ∆R<sub>max-R0</sub> (r = 5973, r<sup>2</sup> = 0.3568; P = 0.001). Both ∆R<sub>max-R0</sub> (P = 0.009) and CPB duration (P < 0.001) were identified as predictors of DSB. In conclusion, both magnitude of peak response of the mAP/mPAP ratio and CPB duration were associated with DSB.
Photoluminescence Spectrum in Silicon Measured by Confocal and Nonconfocal Systems (2011)

LGEP 2011 ID = 888
The 12-s-cis-locked retinoids (vitamin A): synthesis and novel spectral properties (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe 12-s-cis-locked retinoids (vitamin A): synthesis and novel spectral propertiesRoshantha A. S. Chandraratna and William H. OkamuraCite this: J. Am. Chem. Soc. 1982, 104, 22, 6114–6115Publication Date (Print):November 1, 1982Publication History Published online1 May 2002Published inissue 1 November 1982https://pubs.acs.org/doi/10.1021/ja00386a046https://doi.org/10.1021/ja00386a046research-articleACS PublicationsRequest reuse permissionsArticle Views145Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts