gebhart/patrepeval huggingface dataset:
An Architecture for Internet Data Transfer (2018)

This paper presents the design and implementation of DOT, a flexible architecture for data transfer. This architecture separates content negotiation from the data transfer itself. Applications determine what data they need to send and then use a new transfer service to send it. This transfer service acts as a common interface between applications and the lower-level network layers, facilitating innovation both above and below. The transfer service frees developers from re-inventing transfer mechanisms in each new application. New transfer mechanisms, in turn, can be easily deployed without modifying existing applications. We discuss the benefits that arise from separating data transfer into a service and the challenges this service must overcome. The paper then examines the implementation of DOT and its plugin framework for creating new data transfer mechanisms. A set of microbenchmarks shows that the DOT prototype performs well, and that the overhead it imposes is unnoticeable in the wide-area. End-to-end experiments using more complex configurations demonstrate DOT's ability to implement effective, new data delivery mechanisms underneath existing services. Finally, we evaluate a production mail server modified to use DOT using trace data gathered from a live email server. Converting the mail server required only 184 lines-of-code changes to the server, and the resulting system reduces the bandwidth needed to send email by up to 20%.
Squid: The Definitive Guide (2004)

Squid is the most popular Web caching software in use today, and it works on a variety of platforms including Linux, FreeBSD, and Windows. Written by Duane Wessels, the creator of Squid, Squid: The Definitive Guide will help you configure and tune Squid for your particular situation. Newcomers to Squid will learn how to download, compile, and install code. Seasoned users of Squid will be interested in the later chapters, which tackle advanced topics such as high-performance storage options, rewriting requests, HTTP server acceleration, monitoring, debugging, and troubleshooting Squid.
Large ion beams: fundamentals of generation and propagation (1988)

Collisionless Space Charge Phenomena Collisionless Plasmas Collisional Effects Ion Extraction and Acceleration Propagation of High Poissance Beams Ion Source Cathodes Taxonomy of Positive Ion Sources Surface Ionization Sources Negative Ion Sources Appendix: Problem Solutions.
Estimation de la vitesse radiale robuste aux perturbations additives d'une cible marine dans un contexte ISAR (2011)

National audience
Multicenter Phase I Trial of Ivosidenib as Maintenance Treatment Following Allogeneic Hematopoietic Cell Transplantation for IDH1 -Mutated Acute Myeloid Leukemia (2023)

Ivosidenib is safe and well-tolerated as maintenance therapy following HCT. Cumulative incidence of relapse and NRM, as well as estimations of PFS and OS, were promising in this phase I study.
Inhibition of metastasis-associated lung adenocarcinoma transcript 1 in CaSki human cervical cancer cells suppresses cell proliferation and invasion (2010)

Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is suggested to be a long (~7 kb) non-coding RNA. MALAT1 is overexpressed in many human carcinomas, but its function remains unknown. To investigate the role of MALAT1 in human cervical cancer progression, we designed and used short hairpin RNA to inhibit MALAT1 expression in CaSki cells and validated its effect on cell proliferation and invasion. Changes in gene expression were analyzed by reverse transcriptase- polymerase chain reaction. Our data demonstrated that MALAT1 was involved in cervical cancer cell growth, cell cycle progression, and invasion through the regulation of gene expression, such as caspase-3, -8, Bax, Bcl-2, and BclxL, suggesting that MALAT1 could have important implications in cervical cancer biology. Our findings illustrate the biological significance of MALAT1 in cervical cancer progression and provide novel evidence that MALAT1 may serve as a therapeutic target in the prevention of human cervical cancer.
Macrocyclic oxalactones (1953)

Abstract Three new macrocyclic oxalactones have been prepared. Their synthesis and properties are described, and a new technique for the preparation of ω‐bromo‐alkanols is introduced.
ChemInform Abstract: PHOTOCYCLIZATION OF 2,6‐DICHLOROCINNAMIC ACID DERIVATIVES TO 5‐CHLOROCOUMARIN (1983)

Abstract Aus den 2,fm‐Dichlor‐zimtsäureestern (I) erhält man bei der Bestrahlung über die cis‐Form (II) das S‐Chlor‐cumarin (III).
Deciphering the role of Gi2 in opioid-induced adenylyl cyclase supersensitization (2000)

Prolonged opioid treatment of HEK 293 cells expressing opioid receptors are known to induce adenylyl cyclase supersensitization, a process that requires pertussis toxin (PTX)-sensitive G(i/o) proteins. Here, the role of Gi2 in adenylyl cyclase supersensitization was investigated. A PTX-insensitive G alpha(i2)/z chimera was stably co-expressed with mu-, kappa- or delta-opioid receptors in HEK 293 cells. Functional coupling of G alpha(i2)/z to the opioid receptors was demonstrated by opioid-induced inhibition of adenylyl cyclase and stimulation of ERK1/2 phosphorylation in PTX-treated cells. Chronic opioid treatment of each cell line led to adenylyl cyclase supersensitization but this response was blocked by PTX. Our results demonstrated that although PTX-sensitive G proteins are obligatory for opioid-induced adenylyl cyclase supersensitization, Gi2 alone was insufficient to mediate this response.
Roller Compaction - Impact of Dynamic Drums in Comparison (2014)

In the presented study two different types of excitation for the dynamic roller drum are compared in terms of their impact on soil, the vibratory drum and the oscillatory drum. Their differences in functioning, mode of operation and loading the soil are outlined. First results of large-scale in-situ tests are presented in which the vertical earth pressure, deformations and tri-axial accelerations have been measured. Moreover, the influence of the type of excitation on ambient vibrations is discussed.
Improved A* Multi-AGV Path Planning Algorithm Based on Grid-Shaped Network (2019)

In this paper, a kind of two-dimensional coded mark is designed to guarantee that the multi-AGV could locate and execute motion commands in a grid-shaped path network. Then, according to the multi-AGV grid-shaped path network, an improved $\mathrm {A}^{*}$ path planning method is proposed. Finally, the path planning and collision avoidance of multi-AGV in the grid-shaped network is realized, and the effectiveness of the proposed method is demonstrated by numerical simulation experiments.
Effectiveness of Brief Mindfulness-based Intervention among Students with High Neuroticism based on Peripheral Physiological Data: A Preliminary Study (2022)

Stress is a major problem among university students due to the circumstances from internal as well as external such as relationship problems, low self-confidence, and academic pressure. We administered self-report questionnaires and acquired peripheral physiological signals to observe the effectiveness of a brief mindfulness-based intervention (MI) in improving relaxation and thus reducing stress. It was found that skin conductance (SC) showed significant change with p=0.0016 after MI unlike blood volume pulse (BVP) and respiratory rate (RR), even though both were found to be slightly better than that before MI during the resting states and Stroop Task. SC can thus be a potential indicator for the effectiveness of MI in helping the student subjects to cope with stress better and to improve their relaxation and attention levels.
ESR observation of the microstructure of polymer carbon-black composites. Correlation with dielectric properties (2002)

We describe the results of an experimental study of the dielectric and physicochemical properties of a composite material prepared by incorporating carbon black particles into a polymer matrix. The analysis of the carbon black concentration dependence of the amplitudes and linewidths of the ESR signals indicates that ESR is an important experimental probe of the structure of the elasticity network. Sorption kinetics experiments with toluene indicate that the uptake of solvent exhibits a square root dependence in time as a consequence of Fick's law and permit one to evaluate the effective diffusion coefficient in the range 10/sup -10/-10/sup -11/ cm/sup 2/ s/sup -1/ depending on the mass fraction of the carbon black in the sample.
Plasma treatments to improve metal contacts in graphene field effect transistor (2011)

Graphene formed via chemical vapor deposition was exposed to various plasmas (Ar, O2, N2, and H2) in order to examine its effects on the bonding properties of graphene to metal. After exposing patterned graphene to Ar plasma, the subsequently deposited metal electrodes remained intact, enabling the successful fabrication of field effect transistor arrays. The effects of the enhanced adhesion between graphene and metals were more evident from the O2 plasma than the Ar, N2, and H2 plasmas, suggesting that a chemical reaction of O radicals imparts hydrophilic properties to graphene more effectively than the chemical reaction of H and N radicals or the physical bombardment of Ar ions. The electrical measurements (drain current versus gate voltage) of the field effect transistors before and after Ar plasma exposure confirmed that the plasma treatment is quite effective in controlling the graphene to metal bonding accurately without the need for buffer layers.
Development if healthy milk and yogurt products for reducing metabolic diseases using cyclodextrin and omega-3 fatty acids from fish oil (2022)

The food industry is constantly attempting to develop better products that will have a positive effect on health. Feiraco® and Clesa®, expressed their intention to create novel products using UNICLA® milk as a matrix to develop functional foods. In this respect, β-cyclodextrin (β-CD) at 1% was able to reduce the cholesterol concentration in Feiraco-UNICLA® milk products by around 87-85%. Products were fortified with omega-3 from fish oil with α- and β-CD acting as carriers. It was possible to add around 50% of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) Recommended Dietary Allowances (RDA), with a high diet proportion of fibre and similar organoleptic properties to commercial omega-3 products. 80% of a sensory panel found our formulations satisfactory. The final product was stable, and the bioaccessibilty of the fatty acids added to the milk was around 74%. These results as a whole satisfy the aid of Feiraco® and Clesa® to develop improved products.
Radiation Risk to Children From Computed Tomography (2007)

Imaging studies that use ionizing radiation are an essential tool for the evaluation of many disorders of childhood. Ionizing radiation is used in radiography, fluoroscopy, angiography, and computed tomography scanning. Computed tomography is of particular interest because of its relatively high radiation dose and wide use. Consensus statements on radiation risk suggest that it is reasonable to act on the assumption that low-level radiation may have a small risk of causing cancer. The medical community should seek ways to decrease radiation exposure by using radiation doses as low as reasonably achievable and by performing these studies only when necessary. There is wide agreement that the benefits of an indicated computed tomography scan far outweigh the risks. Pediatric health care professionals' roles in the use of computed tomography on children include deciding when a computed tomography scan is necessary and discussing the risk with patients and families. Radiologists should be a source of consultation when forming imaging strategies and should create specific protocols with scanning techniques optimized for pediatric patients. Families and patients should be encouraged to ask questions about the risks and benefits of computed tomography scanning. The information in this report is provided to aid in decision-making and discussions with the health care team, patients, and families.
Iron-Catalyzed Cross-Coupling of Alkenyl Sulfides with Grignard Reagents (2005)

[reaction: see text] The iron-catalyzed cross-coupling reaction of alkenyl sulfides with Grignard reagents is described. While the cross-coupling proceeds efficiently at alkenyl-S bonds, almost no cross-coupling takes place at aryl-S bonds, attesting to a unique selectivity of iron catalysis. The beneficial effect of potentially coordinating 2-pyrimidyl group on sulfur is also described.
Improved Low‐Temperature Environmental Degradation of Yttria‐Stabilized Tetragonal Zirconia Polycrystals by Surface Encapsulation (1999)

An encapsulating layer was deposited on the surface of tetragonal zirconia polycrystals doped with 3 mol% of yttria (3Y‐TZP), to prevent low‐temperature environmental degradation (aging) of the material. The layer, which was composed of silica and zircon, was formed on the surface by exposing the specimens next to a bed of silicon carbide powder in a flowing hydrogen atmosphere that contained ∼0.1% water vapor at 1450°C. The layer was ∼0.5 µm thick and is expected to be under strong residual compressive stress. This encapsulation process remarkably improved the low‐temperature degradation of the material. The strength of the specimens also was improved by this process.
In-Cylinder Fuel Distribution, Flow Field, and Combustion Characteristics of a Mixture Injected SI Engine (1995)

&lt;div class="htmlview paragraph"&gt;In order to control the mixture formation, a mixture injected 4-valve SI engine was developed with a small mixture chamber and mechanically driven mixture injection valve installed into the cylinder head. The mixture injection valve was located at the center of the combustion chamber. The mixture was injected from the final stage of the intake stroke to the beginning of the compression stroke. The mixture distribution and in-cylinder flow field inside the combustion chamber were measured by a pair of laser two-dimensional visualization techniques. A planar-laser-induced exciplex fluorescence technique was used to visualize the in-cylinder mixture formation by obtaining spectrally separated fluorescence images of liquid and vapor phase fuel distribution. Particle image velocimetry (PIV) was used to obtain flow field images. In the case of the mixture injected SI engine, the mixture injected into the swirl center was retained during the compression stroke. A high concentration of fuel vapor still remained and was distributed near the center of combustion chamber until the final stage of compression stroke. The impinged fuel on the cylinder wall was decreased as compared with that of a conventional port injection. Combustion characteristics and engine performance of the mixture injected SI engine were also measured under various engine operating conditions, and the relationship of combustion stability and mixture distribution was discussed. The mixture injected SI engine had a high combustion rate and high combustion stability under lean operating conditions in comparison with homogeneous combustion of a conventional port injection engine. The limit air/fuel ratio could reach over 40. It was clear that the optimization of mixture distribution was very effective to increasing combustion stability under lean operating conditions.&lt;/div&gt;
Incorporation of [α-2H]- and [α-3H]-L-cystine into penicillin G and the location of the label using isotope exchange and2H nuclear magnetic resonance (1975)

The feeding of L-[α2H]- and L-[α-3H]-cystine to Penicilliun chrysogenum affords [6-2H]- and [6-3H]- penicillin G, thus confirming that an αβ-dehydrocysteine residue is not involved in the biosynthetic pathway.
Learning to Multitask (2018)

Multitask learning has shown promising performance in many applications and many multitask models have been proposed. In order to identify an effective multitask model for a given multitask problem, we propose a learning framework called learning to multitask (L2MT). To achieve the goal, L2MT exploits historical multitask experience which is organized as a training set consists of several tuples, each of which contains a multitask problem with multiple tasks, a multitask model, and the relative test error. Based on such training set, L2MT first uses a proposed layerwise graph neural network to learn task embeddings for all the tasks in a multitask problem and then learns an estimation function to estimate the relative test error based on task embeddings and the representation of the multitask model based on a unified formulation. Given a new multitask problem, the estimation function is used to identify a suitable multitask model. Experiments on benchmark datasets show the effectiveness of the proposed L2MT framework.
Insulin-like Growth Factor Binding Protein-2 (IGFBP2) Is a Key Molecule in the MACC1-Mediated Platelet Communication and Metastasis of Colorectal Cancer Cells (2021)

Tumor cell crosstalk with platelets and, subsequently, their activation are key steps in hematogenous tumor metastasis. MACC1 is an oncogene involved in molecular pathogenesis of colorectal cancer (CRC) and other solid tumor entities, mediating motility and metastasis, making MACC1 an accepted prognostic biomarker. However, the impact of MACC1 on platelet activation has not yet been addressed. Here, we investigated the activation of platelets by human CRC cells upon MACC1 modulation, indicated by platelet aggregation and granule release. These approaches led to the identification of insulin-like growth factor binding protein-2 (IGFBP2) as a functional downstream molecule of MACC1, affecting communication with platelets. This was confirmed by an shRNA-mediated IGFBP2 knockdown, while maintaining MACC1 activity. Although IGFBP2 displayed an attenuated platelet activation potential, obviously by scavenging IGF-I as a platelet costimulatory mediator, the MACC1/IGFBP2 axis did not affect the thrombin formation potential of the cells. Furthermore, the IGFBP2/MACC1-driven cell migration and invasiveness was further accelerated by platelets. The key role of IGFBP2 for the metastatic spread in vivo was confirmed in a xenograft mouse model. Data provide evidence for IGFBP2 as a downstream functional component of MACC1-driven metastasis, linking these two accepted oncogenic biomarkers for the first time in a platelet context.
The detection by enzyme‐linked immunosorbent assays of non‐complement‐ fixing HLA antibodies in transfusion medicine (1998)

ELISAs detect some but not all clinically significant HLA antibodies, irrespective of their ability to fix complement in vitro.
Real-time MRI-TRUS fusion for guidance of targeted prostate biopsies (2008)

Targeted prostate biopsy is challenging because no currently established imaging modality is both accurate for prostate cancer diagnosis and cost-effective for real-time procedure guidance. A system that fuses real-time transrectal ultrasound images with previously acquired endorectal coil MRI images for prostate biopsy guidance is presented here. The system uses electromagnetic tracking and intraoperative image registration to superimpose the MRI data on the ultrasound image. Prostate motion is tracked and compensated for without the need for fiducial markers. The accuracy of the system in phantom studies was shown to be 2.4 +/- 1.2 mm. The fusion system has been used in more than 20 patients to guide biopsies with almost no modification of the conventional protocol. Retrospective clinical evaluation suggests that clinically acceptable spatial accuracy can be achieved.
Inherently Chiral Ionic Liquids with Axial, Helical and Central Stereogenicity for Highly Efficient Enantioselective Sensors (2019)

We recently defined as inherently functional materials the compounds in which the stereogenic scaffold responsible for chirality and the molecular group responsible for their specific properties coincide. This structural
combination results in outstanding enantioselection properties, much higher than those exhibited by the compounds in which stereogenic unit and functional group are independent molecular portions. We first tested the validity of this concept in the design of macrocyclic fully conjugated poly-thiophenes in which chirality results from a tailored distortion
of regio-regular oligo-thiophene sequences.
They were employed as highly stereoselective electrode surfaces. We decided to apply the inherent chirality concept to Chiral Ionic Liquids (CILs), experimenting first the effects produced by a stereogenic axis and then extending the research to completely new Inherently Chiral Ionic Liquids (ICILs) based on helices and classical stereocenters. In our project the ICILs based on a stereogenic axis are characterized by suitably substituted 3,3’-bipyridinium or 1,1’-
bibenzimidazolium atropisomeric scaffolds. Considering that pyridinium and imidazolium groups are classical IL
functionalities, and that a pair of them are involved in the hindered rotation around the interannular bond, responsible for chirality, it is evident that the attribute of ICILs to these compounds is correct. Aza- and di-azahexahelicenium
cations also fulfill the requirements to be defined as ICILs, since the pyridinium unit is essential part of the helical
scaffold. As for ICILs based on stereogenic centers, we have planned the alkylation of configurationally stable phosphanes as the key step to easily obtain them. Synthesis and characterization of all new ICILs and electrochemical enantio-differentiation experiments of the antipodes of several chiral probes are discussed in comparison with the behaviour of classical CILs.
ChemInform Abstract: Enantioselective Total Synthesis of Epothilones A and B Using Multifunctional Asymmetric Catalysis. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Platinum(II) Complexes Containing Quaternized Nitrogen Ligands: Synthesis, Stability, and Evaluation as Catalysts for Methane and Benzene H/D Exchange (2009)

This paper describes an efficient synthesis of the cationic platinum complex [(N-CH3-bpym)PtCl2]+ (N-CH3-bpym = N-methylbipyrimidinium) and evaluation of its catalytic activity in H/D exchange reactions of CH4 (with D2SO4) and benzene (with CF3CO2D). With both substrates [(N-CH3-bpym)PtCl2]+ shows C−H activation reactivity comparable to that of its neutral analogue (bpym)PtCl2 (bpym = bipyrimidine). The origin of this similar reactivity is proposed to be the in situ formation of the same active catalyst in both cases.
Robust color object tracking method against illumination color Change (2014)

Color information is one of the most important keys in object tracking. Color appearance of objects depends on illumination color. Therefore, object tracking by color information does not work well in environments with illumination color changes. In some computer vision algorithms, illumination changes are compensated by brightness correction. However, the compensation is insufficient for tracking in recent indoor environments with some types of fluorescent lights and LEDs. The color changes by illumination should be considered in color object tracking. This paper presents an object tracking method based on the gray world assumption (GWA) that relates to the color constancy in human vision. The average color in the vision is regarded as neutral gray in the GWA. In this method, the object color is defined as relative values from the average color in the frame of the image sequence, based on the GWA. Particle filter is used for robust tracking against sudden situation changes. We applied the proposed method to person tracking. Several experiments were examined for evaluation of the proposed method. The experimental results showed good feasibility of the proposed method.