gebhart/patrepeval huggingface dataset:
Flowrate measurement on metal pipes by air-coupled ultrasound (2016)

The characteristics of the measurement capacity of air-coupled ultrasonic sensor influenced by the incident angle were investigated analytically and experimentally. The optimized incident angle between ultrasound and test pipe was determined. The air-coupled ultrasonic sensor with this determined incident angle was applied to the flowrate measurement in the aluminium pipe. The measurement results were compared to those obtained by using the electromagnetic flowmeter. Since the measurement results show good linearity, the capacity of the air-coupled ultrasonic flowmeter is revealed.
Effects of dimethyloxalylglycine on wound healing of palatal mucosa in a rat model (2015)

DMOG enhanced wound healing of rat palatal mucosa, which was likely due to the angiogenic effect of the agent.
Acoustic Ear Recognition for Person Identification (2006)

In this paper we investigate how the acoustic properties of the pinna-i.e., the outer flap of the ear- and the ear canal can be used as a biometric. The acoustic properties can be measured relatively easy with an inexpensive sensor and feature vectors can be derived with little effort. We achieve equal error rates in the order of 1.5%-7%, depending on the application device that is used to do the measurement.
Dynamic thermal behaviour of buildings with concrete core activation (2012)

The dynamic behaviour of buildings equipped with thermally activated building elements is not yet fully understood. This hampers the respons prediction of these low energy buildings on specific internal or external loads. Therefore, modelling of the mutual interaction between building and HVAC-installation is required. Model validation is performed based on dedicated experiments as well as measurement campaigns in existing buildings. This will result in a thourough understanding of the building behaviour and its installation leading to the development of design guidelines. Special attention will be given to the use of heat pumps in combination with the ground as an energy source for both cooling and heating.
Novel Organization of Genes Involved in Prophage Excision Identified in the Temperate Lactococcal Bacteriophage TP901-1 (1999)

In this work, the phage-encoded proteins involved in site-specific excision of the prophage genome of the temperate lactococcal bacteriophage TP901-1 were identified. The phage integrase is required for the process, and a low but significant frequency of excision is observed when the integrase is the only phage protein present. However, 100% excision is observed when the phage protein Orf7 is provided as well as the integrase. Thus, Orf7 is the TP901-1 excisionase, and it is the first excisionase identified that is used during excisive recombination catalyzed by an integrase belonging to the family of extended resolvases. Orf7 is a basic protein of 64 amino acids, and the corresponding gene (orf7) is the third gene in the early lytic operon. This location of an excisionase gene of a temperate bacteriophage has never been described before. The experiments are based on in vivo excision of specifically designed excision vectors carrying the TP901-1 attP site which are integrated into attB on the chromosome of Lactococcus lactis. Excision of the vectors was investigated in the presence of different TP901-1 genes. In order to detect very low frequencies of excision, a method for positive selection of loss of genetic material based upon the upp gene (encoding uracil phosphoribosyltransferase) was designed, since upp mutants are resistant to fluorouracil. By using this system, frequencies of excision on the order of 10(-5) per cell could easily be measured. The described selection principle may be of general use for many organisms and also for types of deletion events other than excision.
Beneath the horizon (2010)

The sinking of the Deepwater Horizon is a disaster for the personnel who were killed, for the environment, and for deep-water drilling. However, an array of underwater vehicle technology has benefited. The subsea activities being undertaken in response to the tragic incidents aboard the Deepwater Horizon semisubmersible mobile drilling unit (MODU) have been performed by remotely operated vehicles (ROVs). ROVs are underwater robots powered and controlled from a surface vessel or platform via an umbilical. The ROVs used are equipped with dual manipulators and are of a grouping known as 'work-class' (WROV) as they perform the work that would have historically been undertaken by divers in shallow waters.
Spectrum of Surgically Resected Lesions of the Cavernous Sinus: A Neuropathologic Audit (2022)

<b>Background</b> The cavernous sinus is a complex space composed of extradural venous plexus within dural folds. Several important structures like the carotid artery, cranial nerves, and sympathetic nerve fibers traverse through this space. Radiological diagnosis may not be definitive and in the context of discordance between clinical and neuroimaging diagnosis, histopathological evaluation becomes essential for diagnosis and management. Literature on the pathological spectrum of lesions is scarce as, with a shift in the treatment paradigm, most small lesions of cavernous sinus are treated with radiosurgery. However, surgical management still plays a role for larger lesions and in radiologically ambiguous cases for planning the definitive management. <b>Materials and Methods</b> We retrospectively reviewed all surgically resected lesions of the cavernous sinus over the last two decades (1998-2019). The clinical presentation, neuroimaging features, and histopathological findings were reviewed. Lesions extending from sella and other adjacent areas were excluded. <b>Results</b> Thirty-eight cases of isolated cavernous sinus mass lesions were diagnosed over the last two decades (1998-2019). Cavernous hemangiomas (19 cases, 50%) constituted the most frequent pathology, followed by aspergilloma, meningioma, schwannoma, metastatic adenocarcinoma, chondrosarcoma, and chordoma. Overall, 29.4% (10/34) could not be accurately diagnosed on neuroimaging. Of these, four cases of cavernous hemangiomas were mistaken for either meningioma (three cases) or schwannoma (one case). Neither chordoma nor chondrosarcoma was suspected. <b>Conclusion</b> This is the first study in literature, enumerating the pathological and imaging spectrum of surgically resected cavernous sinus lesions. Cavernous hemangiomas, metastases and chordomas, and chondrosarcoma posed the greatest difficulty in diagnosis on neuroimaging and the reasons for the same are analyzed. In the context of clinical and neuroimaging discordance in diagnosis, pathological characterization becomes essential for appropriate and timely management.
Peer Review #2 of "A docked mutation phenocopies dumpy oblique alleles via altered vesicle trafficking (v0.1)" (2021)

The Drosophila extracellular matrix protein Dumpy (Dpy) is one of the largest proteins encoded by any animal.One class of dpy mutations produces a characteristic shortening of the wing blade known as oblique (dpy o ), due to altered tension in the developing wing.We describe here the characterization of docked (doc), a gene originally named because of an allele producing a truncated wing.We show that doc corresponds to the gene model CG5484, which encodes a homolog of the yeast protein Yif1 and plays a key role in ER to Golgi vesicle transport.Genetic analysis is consistent with a similar role for Doc in vesicle trafficking: docked alleles interact not only with genes encoding the COPII core proteins sec23 and sec13, but also with the SNARE proteins synaptobrevin and syntaxin.Further, we demonstrate that the strong similarity between the doc 1 and dpy o wing phenotypes reflects a functional connection between the two genes; we found that various dpy alleles are sensitive to changes in dosage of genes encoding other vesicle transport components such as sec13 and sar1.Doc's effects on trafficking are not limited to Dpy; for example, reduced doc dosage disturbed Notch pathway signaling during wing blade and vein development.These results suggest a model in which the oblique wing phenotype in doc 1 results from reduced transport of wild-type Dumpy protein; by extension, an additional implication is that the dpy o alleles can themselves be explained as hypomorphs.
Towards a Fully Automated System for Testing and Validating NetApps (2022)

5G technologies provide several advancements regarding low latency and high bandwidth network scenarios, thus enabling new vertical use cases. Nonetheless, the lack of testing and validation mechanisms for NFV-based services poses a severe challenge in reducing their time to market. In this work we showcase a service to automate the validation of 5G NetApps, thus striving towards reducing the time to market of these applications, and introducing a new layer of trust in their reliability and availability
Physical Interaction of Jab1 with Human Serotonin 6 G-protein-coupled Receptor and Their Possible Roles in Cell Survival (2010)

The 5-HT(6) receptor (5-HT(6)R) is one of the most recently cloned serotonin receptors, and it plays important roles in Alzheimer disease, depression, and learning and memory disorders. However, unlike the other serotonin receptors, the cellular mechanisms of 5-HT(6)R are poorly elucidated relative to its significance in human brain diseases. Here, using a yeast two-hybrid assay, we found that the human 5-HT(6)R interacts with Jun activation domain-binding protein-1 (Jab1). We also confirmed a physical interaction between 5-HT(6)R and Jab1 using glutathione S-transferase pulldown, fluorescence resonance energy transfer, co-immunoprecipitation, and immunocyto(histo)chemistry assays. The manipulation of Jab1 expression using Jab1 small interference RNA decreased 5-HT(6)R-mediated activity and cell membrane expression of 5-HT(6)R, whereas overexpression of Jab1 produced no significant effect. In addition, we demonstrated that the activation of 5-HT(6)R induced the translocation of Jab1 into the nucleus and increased c-Jun phosphorylation and the interaction between Jab1 and c-Jun. Furthermore, we found that 5-HT(6)R and Jab1 were up-regulated in middle cerebral artery occlusion-induced focal cerebral ischemic rats and in cultured cells exposed to hypoxic insults, suggesting possible protective roles for 5-HT(6)R and Jab1. These findings suggest that Jab1 provides a novel signal transduction pathway for 5-HT(6)R and may play an important role in 5-HT(6)R-mediated behavior changes in the brain.
Robust and scalable trust management for collaborative intrusion detection (2009)

The accuracy of detecting intrusions within an intrusion detection network (IDN) depends on the efficiency of collaboration between the peer intrusion detection systems (IDSes) as well as the security itself of the IDN against insider threats. In this paper, we study host-based IDNs and introduce a Dirichlet-based model to measure the level of trustworthiness among peer IDSes according to their mutual experience. The model has strong scalability properties and is robust against common insider threats, such as a compromised or malfunctioning peer. We evaluate our system based on a simulated collaborative host-based IDS network. The experimental results demonstrate the improved robustness, efficiency, and scalability of our system in detecting intrusions in comparison with existing models.
Open-label prospective therapeutic clinical trials: oral vancomycin in children and adults with primary sclerosing cholangitis (2020)

In PSC, OV was well-tolerated and was associated with improvement in liver chemistry. A randomized placebo-controlled clinical trial is warranted.
Bioactive properties of Persea lingue Ness (Lauraceae) fruit and leaf extracts (2021)

Persea lingue Ness is a tree species that lives mainly in temperate forests of south-central Chile. Its leaves are used in ethnomedicine, the fruit is a drupe similar to that of the avocado and has not been studied. The aim of this study was to determine the cytotoxicity in leukemia cell and antibacterial activity, along with some chemical content characteristics of P. lingue fruit and leaf extracts. The antibacterial activity was determined by the inhibition of bacterial growth in liquid medium assay against Gram-positive and Gram-negative bacteria. The leukemia cell lines Kasumi-1 and Jurkat were used to evaluate the cytotoxic activity by using propidium iodide and AlamarBlue assays. Total phenolic, flavonoid, condensed tannin, alkaloid and lipid contents were evaluated in the fruit and in the leaf extracts. The antioxidant activity of both extracts were also elavaluated. Leaf extract presented the highest content of total phenols, condensed tannins and flavonoids, and also the highest antioxidant activity. While the fruit extract has a higher amount of lipids and alkaloids and the high antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus megaterium and Micrococcus luteus. The leaf extract only showed activity against M. luteus. Concerning the cytotoxic activity, only the fruit extract showed cytotoxicity against the cell lines Jurkat and Kasumi-1. P. lingue fruit extract is a potential source of biologically active molecules for the development of new drugs to be used in some types of leukemia, as well as antibacterial agent.
Aerobic biological treatment. Water treatment processes (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAerobic biological treatment. Water treatment processesBruce E. RittmannCite this: Environ. Sci. Technol. 1987, 21, 2, 128–136Publication Date (Print):February 1, 1987Publication History Published online1 May 2002Published inissue 1 February 1987https://pubs.acs.org/doi/10.1021/es00156a002https://doi.org/10.1021/es00156a002research-articleACS PublicationsRequest reuse permissionsArticle Views885Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Data from p53R2 Inhibits the Proliferation of Human Cancer Cells in Association with Cell-Cycle Arrest (2023)

&lt;div&gt;Abstract&lt;p&gt;Deregulation of the expression of p53R2, a p53-inducible homologue of the R2 subunit of ribonucleotide reductase, has been found in various human cancer tissues; however, the roles p53R2 plays in cancer progression and malignancy remain controversial. In the present study, we examined changes in gene expression profiles associated with p53R2 in cancer cells, using the analysis of cDNA microarray. Gene set enrichment analysis identified that the gene set regulating cell-cycle progression was significantly enriched in p53R2-silencing human oropharyngeal carcinoma KB cells. Attenuation of p53R2 expression significantly reduced p21 expression and moderately increased cyclin D1 expression in both wild-type p53 cancer cells (KB and MCF-7) and mutant p53 cancer cells (PC3 and MDA-MB-231). Conversely, overexpression of p53R2-GFP resulted in an increase in the expression of p21 and decrease in the expression of cyclin D1, which correlated with reduced cell population in S-phase &lt;i&gt;in vitro&lt;/i&gt; and suppressed growth &lt;i&gt;in vivo.&lt;/i&gt; Furthermore, the MAP/ERK kinase inhibitor PD98059 partially abolished modulation of p21 and cyclin D1 expression by p53R2. Moreover, under the conditions of nonstress and adriamycin-induced genotoxic stress, attenuation of p53R2 in KB cells significantly increased phosphorylated H2AX, which indicates that attenuation of p53R2 may enhance DNA damage induced by adriamycin. Overall, our study shows that p53R2 may suppress cancer cell proliferation partially by upregulation of p21 and downregulation of cyclin D1; p53R2 plays critical roles not only in DNA damage repair but also in proliferation of cancer cells. &lt;i&gt;Mol Cancer Ther; 10(2); 269–78. ©2011 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Sustained Antibody Responses 6 Years Following 1, 2, or 3 Doses of Quadrivalent Human Papillomavirus (HPV) Vaccine in Adolescent Fijian Girls, and Subsequent Responses to a Single Dose of Bivalent HPV Vaccine: A Prospective Cohort Study (2016)

Two doses of 4vHPV provide similar NAb titers as 3 doses for 6 years, although the clinical significance is unknown. A single dose of 4vHPV elicits antibodies that persisted for at least 6 years, and induced immune memory, suggesting possible protection against HPV vaccine types after a single dose of 4vHPV.
Self-assembly fronts in collision: impinging ordering organosilane layers (2013)

Colliding autocatalytic wave-fronts of self-assembling organosilane (OS) layers are generated through the controlled positioning of sources of the volatile OS material at the edges of a silica wafer and through adjustment of the container dimensions in which the wafer sources are placed. The concentration profiles and molecular orientation of the OS colliding wave-fronts are assessed by means of combinatorial near-edge X-ray absorption fine structure (NEXAFS) spectroscopy. For systems involving self-assembly wave-fronts developing from the same OS precursor molecule, the shapes of interfacial region arising from front collision are centro-symmetrical and slowly ‘heal’ to form a uniform OS layer. In contrast, heterogeneous systems, involving OS molecules having different chemistries exhibit different rates of advance and highly non-symmetrical concentration profiles after front collision. We discuss the general nature of our OS colliding front data in terms of a mean field model of colliding reaction–diffusion fronts that generalizes a model introduced before for describing single OS front propagation.
Effect of mechanochemical treatment on VOPO4 2H2O to produce vanadly pyrophospate catalysts. (2009)

Two vanadly pyrophosphate catalysts were prepared via dihydrate route (VPD method) by appying mechanochemical treatment performed on VOPO42H2O in different duration of time.i.e 30 and 60 min in ethanol medium. Both catalysts with the unmilled catalyst produced were characterized by x-ray diffraction (XRD). chemical analysis, scanning electron microscopy (SEM) and temperature programmed reduction (H2-TPR). Catalytic evaluation for partial oxidation of n-butane to maleic anhydride (MA) was also being carried out using microreactor. XRD patterns of all VPO catalysts showed the main peaks of pyrophosphate phase. TPR profiles showed that the mechanochemical treated VPO catalyst for 30 min (VPDM30) removed the active oxygen species at lower temperature. Futhermore, from the catalytic test result, the graph of the catalytic performance as a funtion of the duration of mechanochemical treatment demonstrates that VPDM30 is the most active catalyst. This suggested that the mechanochemical treatment of the VOPO4 2H2O for the synthesis of pyrophosphate catalyst (VPDM30) is highly potential to enhance the catalytic properties for n-butane oxidation towards maleic anhydride.
Interneuron Control of C. elegans Developmental Decision-making (2021)

SUMMARY Animals integrate external stimuli to shape their physiological responses throughout development. In adverse environments, Caenorhabditis elegans larvae can enter a stress-resistant diapause state with arrested metabolism and reproductive physiology. Amphid sensory neurons feed into both rapid chemotactic and short-term foraging mode decisions, mediated by amphid and premotor interneurons, as well as the long-term diapause decision. We identify amphid interneurons that integrate pheromone cues and propagate this information via a neuropeptidergic pathways to influence larval developmental fate, bypassing the pre-motor system. AIA interneuron-derived FLP-2 neuropeptide signaling promotes reproductive growth and AIA activity is suppressed by pheromone. FLP-2 acts antagonistically to the insulin-like INS-1. FLP-2’s growth promoting effects are inhibited by upstream metabotropic glutamatergic signaling and mediated by the broadly-expressed neuropeptide receptor NPR-30. Conversely, the AIB interneurons and their neuropeptide receptor NPR-9/GALR2 promote diapause entry. These neuropeptidergic outputs allow reuse of parts of a sensory system for a decision with a distinct timescale.
Dermoscopy and Reflectance Confocal Microscopy in the Diagnosis and Management of Nail Fold Squamous Cell Carcinoma (2020)

The management and prognosis of squamous cell carcinoma largely depend on its invasiveness and grade of differentiation. Pigmented nail fold squamous cell carcinoma represents a therapeutic challenge, needing careful treatment to preserve nail function. Here, we report the use of dermoscopy and Reflectance Confocal Microscopy to monitor nail fold squamous cell carcinoma in situ and its response to treatment with topical imiquimod.
Celecoxib reduces narcotic use and pain following augmentation mammaplasty (2006)

Perioperative celecoxib administration in patients undergoing augmentation mammaplasty significantly reduced postoperative narcotic use, pain, and nausea. Its use should facilitate the patient's ability to resume everyday activities following surgery.
Decision-Oriented Communications: Application to Energy-Efficient Resource Allocation (2018)

In this paper, we introduce the problem of decision-oriented communications, that is, the goal of the source is to send the right amount of information in order for the intended destination to execute a task. More specifically, we restrict our attention to how the source should quantize information so that the destination can maximize a utility function which represents the task to be executed only knowing the quantized information. For example, for utility functions under the form u (x; g), x might represent a decision in terms of using some radio resources and g the system state which is only observed through its quantized version Q(g). Both in the case where the utility function is known and the case where it is only observed through its realizations, we provide solutions to determine such a quantizer. We show how this approach applies to energy-efficient power allocation. In particular, it is seen that quantizing the state very roughly is perfectly suited to sum-rate-type function maximization, whereas energy-efficiency metrics are more sensitive to imperfections.
Antifungal Mechanism of a Novel Antifungal Protein from Pumpkin Rinds against Various Fungal Pathogens (2009)

A novel antifungal protein (Pr-2) was identified from pumpkin rinds using water-soluble extraction, ultrafiltration, cation exchange chromatography, and reverse-phase high-performance liquid chromatography. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry indicated that the protein had a molecular mass of 14865.57 Da. Automated Edman degradation showed that the N-terminal sequence of Pr-2 was QGIGVGDNDGKRGKR-. The Pr-2 protein strongly inhibited in vitro growth of Botrytis cinerea, Colletotrichum coccodes, Fusarium solani, Fusarium oxysporum, and Trichoderma harzianum at 10-20 microM. The results of confocal laser scanning microscopy and SYTOX Green uptake demonstrated that its effective region was the membrane of the fungal cell surface. In addition, this protein was found to be noncytotoxic and heat-stable. Taken together, the results of this study indicate that Pr-2 is a good candidate for use as a natural antifungal agent.