gebhart/patrepeval huggingface dataset:
Admissions for neutropenic fever in myelodysplastic syndromes (MDS). (2019)

e18548 Background: MDS are associated with a risk of severe infections due to disease course, patient (pt) age, co-morbidities and treatment. While infection rates have been reported for MDS patients enrolled in clinical trials, the real-world incidence of infections that require hospitalization, and how disease related factors (e.g. genetic mutations) affect the likelihood of infection remain unclear. Methods: Clinical data for MDS pts (per 2016 WHO criteria) diagnosed between 1/2010-12/2016, and treated at the Cleveland Clinic were included. TET2 mutation data obtained by NGS (in the context of genomic panel) was also included. Results: Our dataset included 214 pts of median age 70 years (range 13-99), with 33%, 54%, and 12% having low, intermediate, and high risk MDS according to IPSS-R. Overall, 100 admissions for neutropenic fever were recorded with a median length of stay of 5 days per admission; 63 (29%) pts required at least one admission, and of these 9 (14%) pts required 3 or more (up to 6) admissions. Blood cultures were positive in 17 (27%) pts with common organisms including Staphylococcus (38%), Enterococcus (35%), and Pseudomonas (12%). Urine cultures were positive in 6 (10%) pts, with organisms including E. Coli (50%), Pseudomonas (17%) and Klebsiella (17%). Fungal work up was sent in 18 (29%) pts and was positive in 3 (17%) pts. 13 (21%) pts required ICU transfer, and of those 7 (51%) pts required vasopressor support, and 10 (77%) pts required mechanical ventilation. Median ICU length of stay was 3 days (range 1-26). 13 (21%) pts were discharged on IV antibiotics. Median OS for the entire cohort was 18 months (95% CI 7.9 – 34.7), and median OS for admitted patients was not significantly shorter at 48 or 65 months. The number of admissions for neutropenic fever, length of stay, IPSS-R risk category, TET2 mutation, and ICU transfer did not impact survival. Conclusions: The risk of admission for neutropenic fever was 29% with blood cultures positive in 27% of pts. TET2 mutation status and IPSS-R risk did not impact admission rate, length of stay or ICU transfer.
Context-aware multimedia streaming service for smart home (2008)

This paper presents a context-aware multimedia seamless streaming system where the context is transmitted by a Zigbee-based sensor network. In the system, we employ Open Systems Gateway Initiative (OSGi) framework to provide the communication service of DLNA and Zigbee devices. By the system, a user's preferences for the multimedia service, such as media title, audio volume, video brightness/contrast and time stamp, will be carried by the Zigbee network to enable the identical atmosphere at where the user roamed. The DLNA player retrieves the media and plays out based on those preferences. The system aims at providing an identical seamless multimedia streaming service in a future smart home.
Rearrangement of dihalocyclopropanes derived from some 6,7-dihydrobenzo[b]thiophenes (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRearrangement of dihalocyclopropanes derived from some 6,7-dihydrobenzo[b]thiophenesClaude V. Greco and Vincent G. GrossoCite this: J. Org. Chem. 1973, 38, 1, 146–151Publication Date (Print):January 1, 1973Publication History Published online1 May 2002Published inissue 1 January 1973https://pubs.acs.org/doi/10.1021/jo00941a032https://doi.org/10.1021/jo00941a032research-articleACS PublicationsRequest reuse permissionsArticle Views99Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
N-Aryl-N'-Benzylpiperazines as Potential Antipsychotic Agents (1995)

N1-(2-Alkoxyphenyl)piperazines additionally containing an N4-benzyl group bearing alcohol, amide, imide, or hydantoin functionalities were prepared and evaluated in the conditioned avoidance response (CAR) test predictive of clinical antipsychotic activity and in in vitro receptor-binding assays. Certain of the compounds display high affinity for the D2, 5-HT1A, and alpha 1-adrenergic receptors. Structures bearing acyclic amide, lactam, and imide functionalities display good biological activity, with a preference for the 1,3-disubstituted phenyl ring relative to the 1,4- and 1,2-congeners (7 vs 10 and 12). Every possible position of hydantoin attachment was investigated (e.g., substitution at N1, N3, and C5). The hydantoin involving attachment to N1 (24) was found to have good biological activity, whereas those hydantoins with attachment to N3 or C5 (22, 23, and 25) were inactive. Several of the smaller acetylated derivatives (30 and 33) have fair in vivo activity, which was lost in the case of the larger benzoyl analog 31. Uracil congener 34 had modest affinity for the D2 receptor (65 nM) as well as excellent in vivo activity. Benzylamino compounds display (viz. 27 and 35-38) moderate CAR activity but have surprising receptor affinity, often greater than those of comparable structures bearing a carbonyl (36 vs 7). Benzyl and benzhydryl alcohol compounds 40-48 are more active than amino structures 27 and 35-38 and also exhibit excellent in vivo activity in the CAR test with modest D2 and 5-HT1A receptor binding.
NAD Glycohydrolase Activities and ADP-Ribose Uptake in Erythrocytes From Normal Subjects and Cancer Patients (2004)

Erythrocytes from cancer patients exhibited up to fivefold higher NAD glycohydrolase activities than control erythrocytes from normal subjects and also similarly increased [14C] ADP-ribose uptake values. When [adenosine-14C] NAD was used instead of free [14C] ADP-ribose, the uptake was dependent on ecto-NAD glycohydrolase activity. This was reflected in the inhibition of ADP-ribose uptake from [adenosine-14C] NAD by Cibacron Blue. ADP-ribose uptake in erythrocytes appeared to be complex: upon incubation with free [14C] ADP-ribose, the radiolabel associated with erythrocytes was located in nearly equal parts in cytoplasm and plasma membrane. Part of [14C] ADP-ribose binding to the membrane was covalent, as indicated by its resistance to trichloroacetic acid-treatment. A preincubation with unlabeled ADP-ribose depressed subsequent erythrocyte NAD glycohydrolase activity and binding of [14C] ADP-ribose to erythrocyte membrane; but it failed to inhibit the transfer of labeled ADP-ribose to erythrocyte cytoplasm. On the other hand, incubation with [adenosine-14C] NAD did not result in a similar covalent binding of radiolabel to erythrocyte membrane. In line with this finding, a preincubation with unlabeled NAD was not inhibitory on subsequent NAD glycohydrolase reaction and ADP-ribose binding. ADP-ribose binding and NAD glycohydrolase activities were found also in solubilized erythrocyte membrane proteins and, after size fractionation, mainly in a protein fraction of around 45kDa-molecular weight.
Minipool testing for SARS‐CoV‐2 RNA in United States blood donors (2021)

Blood donation MP-nucleic acid testing (NAT) indicated that SARS-CoV-2 RNAemia is infrequent and, when detected, the vRNA was at low concentrations. Only one RNA-reactive MP could be tested for infectivity for operational reasons and was not infectious in cell culture. These findings support current recommendations from international and national regulatory agencies to not screen donors by NAT.
Modified Hodge Test versus Indirect Carbapenemase Test: Prospective Evaluation of a Phenotypic Assay for Detection of Klebsiella pneumoniae Carbapenemase (KPC) in Enterobacteriaceae (2013)

The currently recommended phenotypic test for the detection of carbapenemase-producing members of the family Enterobacteriaceae is the modified Hodge test (MHT). However, the MHT lacks specificity. Here we demonstrate an alternative phenotypic test, the indirect carbapenemase test, for the detection of blaKPC-producing isolates that has specificity superior to that of the MHT for non-Klebsiella Enterobacteriaceae.
ArISE: Aging-aware instruction set encoding for lifetime improvement (2014)

Microprocessors fabricated at nanoscale nodes are exposed to accelerated transistor aging due to Bias Temperature Instability and Hot Carrier Injection. As a result, device delays increase over time reducing the Mean Time To Failure (MTTF) of the processor. To address this challenge, many (micro)-architectural techniques target the execution stage of the instruction pipeline, as this one is typically most critical. However, also the decoding stages can become aging-critical and limit the microprocessor lifetime, as we will show in this work. In this paper, we propose a novel aging-aware instruction set encoding methodology (ArISE), that improves the instruction encoding iteratively using a heuristic algorithm. Our experimental results show that MTTF of the decoding stages can be improved by 1.93x with negligible implementation costs.
ANL Technical Support Program for DOE Environmental Restoration and Waste Management; Annual report, October 1992--September 1993 (1994)

This report is an overview of the progress during FY 1993 for the Technical Support Program that is part of the ANL Technology Support Activity for DOE Environmental Restoration and Waste Management (EM). The purpose is to evaluate, before hot start-up of the Defense Waste Processing Facility (DWPF) and the West Valley Demonstration Project (WVDP), factors that are anticipated to affect glass reaction in an unsaturated environment typical of what may be expected for the candidate Yucca Mountain repository site. Specific goals for the testing program include the following: reviewing and evaluating available data on parameters that will be important in establishing the long-term performance of glass in a repository environment; performing tests to further quantify the effects of important variables where there are deficiencies in the available data; and initiating long-term tests to determine glass performance under a range of conditions applicable to repository disposal.
DEVELOPMENT OF A QUANTITATIVE REAL-TIME POLYMERASE CHAIN REACTION ASSAY SPECIFIC FOR ORIENTIA TSUTSUGAMUSHI (2004)

Two specific and sensitive polymerase chain reaction (PCR) assays were developed to detect and quantitate Orientia tsutsugamushi, the agent of scrub typhus, using a portion of the 47-kD outer membrane protein antigen/ high temperature requirement A gene as the target. A selected 47-kD protein gene primer pair amplified a 118-basepair fragment from all 26 strains of O. tsutsugamushi evaluated, but it did not produce amplicons when 17 Rickettsia and 18 less-related bacterial nucleic acid extracts were tested. Similar agent specificity for the real-time PCR assay, which used the same primers and a 31-basepair fluorescent probe, was demonstrated. This sensitive and quantitative assay determination of the content of O. tsutsugamushi nucleic acid used a plasmid containing the entire 47-kD gene from the Kato strain as a standard. Enumeration of the copies of O. tsutsugamushi DNA extracted from infected tissues from mice and monkeys following experimental infection with Orientia showed 27-5552 copies/microL of mouse blood, 14448-86012 copies/microL of mouse liver/spleen homogenate, and 3-21 copies/microL of monkey blood.
Resolution enhancement of hyperspectral imagery using coincident panchromatic imagery and a stochastic mixing model (2004)

A maximum a posteriori (MAP) estimation approach to the hyperspectral resolution enhancement problem is described for enhancing the spatial resolution of a hyperspectral image using a higher resolution, coincident, panchromatic image. The approach makes use of a stochastic mixing model (SMM) of the underlying spectral scene content to develop a cost function that simultaneously optimizes the estimated hyperspectral scene relative to the observed hyperspectral and panchromatic imagery, as well as the local statistics of the spectral mixing model. The incorporation of the stochastic mixing model is found to be the key ingredient to reconstructing subpixel spectral information in that it provides the necessary constraints that lead to a well-conditioned linear system of equations for the high resolution hyperspectral image estimate. The mathematical formulation of the method is described, and enhancement results are provided for a synthetically-generated hyperspectral image data set and compared to prior methods. In general, it is found that the MAP/SMM method is able to reconstruct sub-pixel information in several principal components of the high resolution hyperspectral image estimate, while the enhancement for conventional methods, like those based on least-squares estimation, is limited primarily to the first principal component (i.e., the intensity component).
The Water-Extracted Ampelopsis brevipedunculata Downregulates IL-1β, CCL5, and COX-2 Expression via Inhibition of PKC-Mediated JNK/NF-κB Signaling Pathways in Human Monocytic Cells (2014)

The anti-inflammatory and anti-hepatotoxic effects of Ampelopsis brevipedunculata (A.bre) have been well known in folk medicine. An ethanol-extract of A.bre has been reported to inhibit carbon tetrachloric acid induced hepatic injury, suggesting that extracted components from A.bre could potentially treat inflammatory disease. To test this hypothesis, in this study, we extracted polysaccharide components from leaves of A.bre and investigated the anti-inflammatory effects in PMA stimulated THP-1 cells. THP-1 cells activated by PMA in the presence or absence of A.bre demonstrated that a water-extract of A.bre inhibited the expression of pro-inflammatory cytokine IL-1β and chemokine CCL-5 in a dose-dependent manner. In addition, A.bre suppressed production of cyclooxygenase (COX)-2 in THP-1 cells activated by PMA. Moreover, A.bre markedly down-regulated the expression of p-JNK1/3, whereas it did not inhibit production of the phosphorylated form of p38 and extracellular signal-regulated kinase in THP-1 cells treated by PMA. Particularly, A.bre inhibited the translocation of transcription factor NF-κB from the cytosol into the nucleus in PMA-stimulated THP-1 cells. Collectively, our data showed that water-extracted A.bre inhibited the protein kinase C-JNKs/NF-κB signaling pathways, resulting in the suppression of IL-1β, CCL-5, and COX-2 expression. This study suggests that water extracted A.bre may be a therapeutic agent against inflammatory disease.
A third order delta-sigma modulator employing shared opamp technique for WCDMA on 0.18um CMOS (2011)

Analog to digital converter is a vital component in a wireless transceiver. High order loop filter is one of conventional approach to attain high resolution delta-sigma modulator which required one opamp for each integrator. A third orders delta-sigma modulator (DSM) has been designed utilizing shared opamp technique to reduce number of opamp required and decrease power consumption. Moreover, this architecture has relaxed comparator speed which is appropriate for wireless applications. First and second stages are sharing one opamp in integration and sampling phase. The proposed circuit has been designed on TSMC 0.18um CMOS technology. 2MHz Bandwidth, 50dB Peak SQNR, which is suitable for WCDMA, have been achieved.
A feasibility study of using a smartphone to monitor mobility in elderly (2012)

The increase of the elderly population poses today many questions to maintain elderly people in their own life independently and in autonomy. Daily activity of humans is correlated to the homeostasis and therefore the quantification of the daily activities plays an important role in the evaluation of the health and early detection of the signs of loss of autonomy. The actimetry has a great potential on the market of technologies for the maintenance to residence of the elderly. We propose to follow up actimetric data by using kinematic sensors integrated in a smartphone. The smartphone is a good candidate as this technology is already accepted in daily life.
Capture and Isotopic Exchange Method for Water and Hydrogen Isotopes on Zeolite Catalysts up to Technical Scale for Pre-Study of Processing Highly Tritiated Water (2015)

Highly tritiated water (HTW) may be generated at ITER by various processes and, due to the excessive radio toxicity, the self-radiolysis and the exceedingly corrosive property of HTW, a potential hazard is associated with its storage and process. Therefore, the capture and exchange method for HTW utilizing Molecular Sieve Beds (MSB) was investigated in view of adsorption capacity, isotopic exchange performance and process parameters. For the MSB, different types of zeolite were selected. All zeolite materials were additionally platinized. The following work comprised the selection of the most efficient zeolite candidate based on detailed parametric studies during the H2/D2O laboratory scale exchange experiments (~25 g zeolite per bed) at the Tritium Laboratory Karlsruhe (TLK). For the zeolite, characterization analytical techniques such as Infrared Spectroscopy, Thermogravimetry and online mass spectrometry were implemented. Followed by further investigation of the selected zeolite catalyst under full technical operation, a MSB (~22 kg zeolite) was processed with hydrogen flow rates up to 60 mol h-1 and deuterated water loads up to 1.6 kg in view of later ITER processing of arising HTW.
Clinical potential of engineered cationic antimicrobial peptides against drug resistant biofilms (2016)

KEYWORDS: Biofilm infectionsantimicrobial peptidemultidrug resistancepolymicrobial infectionsrational design
CMOS tapered buffer (1990)

Jaeger's buffer comprises a string of tapered inverters. Each inverter is molded by a capacitor and a conductor. In this work, the capacitor is split into inherent and load components (C/sub x/ and C/sub y/), and it is shown that the value of the optimal taper depends on the C/sub x//C/sub y/ ratio: the best taper exceeds Jaeger's 2.72 slope, but only moderately.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Supplementary Table 2 from Adjuvant Sirolimus Does Not Improve Outcome in Pet Dogs Receiving Standard-of-Care Therapy for Appendicular Osteosarcoma: A Prospective, Randomized Trial of 324 Dogs (2023)

&lt;p&gt;Supplementary Table 2 contains the summary comparison of both the Intent-to-treat and Per-protocol analyses of clinical outcomes for dogs enrolled in Standard of Care (SOC) and Standard of Care + sirolimus&lt;/p&gt;
Adipokines and Adipocyte Targets in the Future Management of Obesity and the Metabolic Syndrome (2006)

The role of adipocytes has been recently better understood. Several adipocytokines have been identified, including leptin, a main regulator of appetite and energy expenditure, adiponectin and others, as novel insulin-sensitizers/insulin-mimetics, and some others inducing insulin resistance. Adipocytokines thus represent interesting novel drug targets in the future management of obesity.
Virtual reality flexible cystoscopy: a validation study (2002)

Using the URO Mentor simulator, it was possible to assess the level of experience of flexible cystoscopy, and therefore the system has construct validity. As in the real situation there is a period of learning during which the subject becomes familiar with the computer/machine/human interface, the task and the handling of the instruments. These results support the view that there is a role for VR simulators in urological training.
Geographic Dissection of the Twitter Network (2021)

Geography plays an important role in shaping societal interactions in the offline world. However, as more and more social interactions occur online via social net- working sites like Twitter and Facebook, users can in- teract with others unconstrained by their geolocations, raising the question: does offline geography still matter in online social networks? In this paper, we attempt to address this question by dissecting the Twitter so- cial network based on users’ geolocations and investi- gating how users’ geolocation impacts their participa- tion in Twitter, including their connections to others and the information they exchange with them. Our in-depth analysis reveals that geography continues to have a sig- nificant impact on user interactions in the Twitter social network. The influence of geography could be poten- tially explained by the shared national, linguistic, and cultural backgrounds of users from the same geographic neighborhood.
ChemInform Abstract: DURCH UEBERGANGSMETALL KATALYSIERTE (2+2)‐′CROSS‐ADDITION′ VON OLEFINEN, NI(0)‐KATALYSIERTE CYCLOADDITION VON NORBORNADIEN AN METHYLENCYCLOPROPAN (1973)

Abstract Norbornadien (II) reagiert mit dem Cyelopropan (III) in Gegenwart von Bis‐ [cyclooctadien‐(l,5)]‐nicke1(O) und Triphenylphosphin zum Cycloaddukt (I).
Spectral imaging for precise surgical intervention in Hirschsprung's Disease (2008)

We used advanced spectral imaging for intrasurgical decision making in a preclinical study, on a mouse model of Hirschsprung's Disease. Our imaging device sampled areas from normal and abnormal (aganglionic) colon in these animals. Spectral segmentation and classification of the resulting images showed a clear distinction between the normal and aganglionic regions, as confirmed by pathological analysis and use of mutant mice. We developed a simple algorithm that could distinguish normal from aganglionic colon with high spatial resolution and reproducibility, and the following statistics: sensitivity = 97%, specificity = 94%, positive predictive value = 92%, negative predictive value = 98%. These studies showed translational proof of concept that spectral imaging could be used during operations, in real time, to help surgeons precisely distinguish normal from abnormal tissue without requiring traditional biopsy.