gebhart/patrepeval huggingface dataset:
Dynamic Argument Reduction for In-memory Data Queries. (1994)

Recently tuple-at-a-time evaluation strategies have begun receiving renewed attention for in-memory data queries, due to the existence of efficient techniques for their implementation. One such technique, the SLG-WAM, forms the basis of the XSB system[9]; performance tests indicate it to be an order of magnitude faster than current deductive databases for a wide range of in-memory queries. The SLG-WAM is based on SLG resolution [5], [4], a resolution method which uses tabling to evaluate normal logic programs 1 . For any tabling method, be it SLG or Magic, access to tabled subgoals and to their answers is critical for efficiency. Concern with this access time has led to optimization techniques, such as those for removing ground arguments from recursive rules. This paper presents table access methods, which combined with the backtracking of the SLG-WAM&amp;apos;s tuple-at-a-time evaluation, allow dynamic reductions in the arguments of inferred predicates at an almost imperceptible cost compare...
von Willebrand Factor Propeptide in Vascular Disorders: A Tool to Distinguish Between Acute and Chronic Endothelial Cell Perturbation (1999)

Before de novo synthesized von Willebrand factor (vWF) leaves the endothelial cell, it undergoes endoproteolytic cleavage of its propeptide (vW antigen II). The processed vWF and propeptide are either released constitutively or, following activation of the endothelium, released through the regulated pathway. In a recent study (Borchiellini et al, Blood 88:2951, 1996), we showed that the half-life of mature vWF and of its propeptide differ fourfold to fivefold. We postulated that the molar ratio of the propeptide to mature vWF could serve as a tool to assess the extent of endothelial cell activation under physiologic and clinical conditions. To test this hypothesis, we measured mature vWF and propeptide in patients with documented acute and chronic vascular disease, including patients with thrombotic thrombocytopenic purpura (TTP), acute septicemia, and diabetes mellitus. These data were compared with experimental conditions in healthy subjects in which perturbation of the endothelium was simulated by physical exercise or by administration of 1-deamino-8-D-arginine vasopressin (DDAVP) or endotoxin. In all individuals of the latter study group, both vWF and propeptide levels were elevated during the acute phase of the experimentally induced vascular perturbation; at later time points after stimulation, only vWF levels remained elevated. In patients with sepsis and TTP, both vWF and propeptide were elevated several-fold. Thus, this pattern can readily be explained in terms of acute perturbation of the endothelium. In contrast, in patients with diabetes mellitus propeptide levels were only slightly elevated, whereas vWF levels were elevated twofold to threefold. This pattern is a typical feature of chronic, low-grade activation of the endothelium. These observations support our hypothesis that measurement of both propeptide and vWF levels allows to discriminate between chronic and acute phases of endothelial cell activation in vivo. Measurement of only vWF is less indicative in this respect.
Torularhodin as a Potent Scavenger against Peroxyl Radicals Isolated from a Soil Yeast, Rhodotorula glutinis. (2001)

A soil yeast Rhodotorula glutinis increased torularhodin, that is one of the final products of carotenoid biosynthesis, when loading oxygen stress. In addition, a mutant of this yeast, which produces torularhodin more than β-carotene, gained resistance to oxygen stress. In this study, changes in carotenoids biosynthesis due to addition of 2, 2'-azobis(2-amidinopropane)-dihydrochloride (AAPH) as a peroxyl radicals generator were examined, and scavenging peroxyl radicals by torularhodin was also compared with that by β-carotene. When 0.01mM AAPH was added to the culture medium, the amount of carotenoids in yeast was increased. With increase in load by AAPH addition, torularhodin was consumed faster than β-carotene. After torularhodin decreased to the same concentration as AAPH free condition, β-carotene began to decrease. These results suggest that torularhodin was important in defense against oxidation loading by peroxyl radicals in R. glutinis. Scavenging of peroxyl radicals by torularhodin was evaluated using electron spin resonance. In the reaction of cumene hydroperoxide and 5, 10, 15, 20-tetraphenyl-21H, 23H-prophine iron (III) [TPP-Fe(III)], torularhodin exhibited concentration-dependent inhibition and its activity reached to 60% at 2.5mM. On the other hand, α-tocopherol exhibited strong activity at low concentrations with a maximum at 0.25mM, but its activity decreased above this concentration. Scavenging activity by torularhodin was greater than that of α-tocopherol at 2.5mM. In the pyrolysis of 2, 2′-azobisisobutyronnitrile (AIBN), both torularhodin and α-tocopherol exhibited concentration-dependent inhibition, but the scavenging activity of α-tocopherol was stronger. In addition, torularhodin inhibited lipid peroxide formation of rat brain homogenate in a concentration-dependent manner, and its inhibitory effect was stronger than that of α-tocopherol at concentration of 1μM and above. Torularhodin thus appears to be an effective scavenger of peroxyl radicals and to have strong antiperoxidative activity. The strong inhibition of lipid peroxidation by torularhodin at low concentration suggests that torularhodin has other activities in addition to peroxyl radical scavenging. R. glutinis tenders to increase the production of torularhodin by load oxygen stress, but this was because of its strong peroxyl radicals scavenging.
Solvolyses in the bishomocubane system. Multistep rearrangements within ion pairs (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSolvolyses in the bishomocubane system. Multistep rearrangements within ion pairsWilliam G. Dauben and Dale L. WhalenCite this: J. Am. Chem. Soc. 1971, 93, 26, 7244–7249Publication Date (Print):December 1, 1971Publication History Published online1 May 2002Published inissue 1 December 1971https://pubs.acs.org/doi/10.1021/ja00755a020https://doi.org/10.1021/ja00755a020research-articleACS PublicationsRequest reuse permissionsArticle Views43Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Nerve growth factor‐β induces mast‐cell marker expression during in vitro culture of human umbilical cord blood cells (2000)

Nerve growth factor-beta (NGF) is known as a growth factor for human basophils and murine mast cells and has recently been shown to also up-regulate mast cell characteristics in human leukaemic mast cells. We have examined here the effect of NGF on the differentiation of normal human mast cells from cord blood progenitors during culture with stem cell factor (SCF), NGF alone or in combination, or fibroblast supernatants. All these supplements induced mast cell immunoreactivity against tryptase, c-Kit and FcepsilonRIalpha, but none of the cells reacted against the basophil specific antibody 2D7 before or during culture. Intracellular tryptase activity increased as well, with maximal levels on combined culture with SCF and NGF. On reverse transcription-polymerase chain reaction (RT-PCR), cells lacked tryptase and chymase and expressed low levels of FcepsilonRI and c-Kit mRNA prior to culture, with marked up-regulation of FcepsilonRI and c-Kit, and with de novo expression of mast-cell specific alpha- and beta-tryptase by week 3, and of chymase by week 5. Only the TrkA and not the p75 NGF receptor was detected at m-RNA and protein level, and only the TrkA NGF receptor was up-regulated during NGF-driven culture. These findings show therefore that, like SCF, NGF is another growth factor that can induce and regulate human mast-cell development and differentiation.
Performance results for the Landsat OLI spectral filters (2009)

This paper presents a summary of the performance of the Landsat Operational Land Imager (OLI) spectral filters. An overview of OLI is presented along with background on filter performance and manufacture. Performance results versus requirements are presented for all key performance metrics.
Evaluation of a Hardware-in-the-loop Test Setup Using Mechanical Measurements with a DFIG Wind Turbine Nacelle (2022)

Abstract The impact of system test benches on the development and validation of wind energy converters is significantly increasing, and that is due to the higher availability as well as the provided powerful actuator and emulation systems. However, the question remains to be answered about how consistent measurements in the laboratory are. Especially in the case where no field measurements are available for prototypes. The challenge in this regard is the unknown accuracy of simulations and the lack of an experimentally calibrated torque measurement in the hardware-in-the-loop (HiL) setup. The presented paper handles this topic and presents an evaluation method to elaborate measurement consistency independent from field tests. A transparent and comprehensive comparison is provided, taking advantage of the deterministic test environment enabled by the HiL system and the dedicated designed torque measurement adapter. Provided results demonstrate consistent measures obtained from the real-time simulation, HiL control system, and the electrical and mechanical measurements, where a low deviation of up to 2 % is partly observed.
Figure S4 from Pharmacological Disruption of the Notch1 Transcriptional Complex Inhibits Tumor Growth by Selectively Targeting Cancer Stem Cells (2023)

&lt;p&gt;NADI-351 inhibits recruitment of Notch1 to the NTC and to the HES1 promoter&lt;/p&gt;
Effects of controlled whole-body vibration training in improving fall risk factors among individuals with multiple sclerosis: A pilot study (2016)

The 8-week vibration training was well accepted by PwMS and improved their fall risk factors. The important findings of this study were that vibration training may increase the range of motion of ankle joints on the sagittal plane, lower the fear of falling, and improve bone density. IMPLICATIONS FOR REHABILITATION An 8-week vibration training course could be well-accepted by people with multiple sclerosis (MS). Vibration training improves the risk factors of falls in people living with MS. Vibration training could be a promising rehabilitation intervention in individuals with MS.
Arboviral causes of non-specific fever and myalgia in a fever hospital patient population in Cairo, Egypt (1987)

Fever and myalgia are non-specific clinical manifestations of illness which commonly occur in patients with arboviral disease. In Egypt, such illness is often mis-diagnosed as "influenza". To determine arboviral aetiology in patients admitted with fever and myalgia, acute and convalescent sera samples were obtained from 55 patients admitted with these clinical manifestations to the Imbaba Fever Hospital, Giza, Egypt, during October and November 1984. Based on viral isolation, and a comparison of acute and convalescent sera, 4 patients (7%) had acute arboviral infections. Haemagglutination inhibition and indirect immunofluorescence tests showed that one had West Nile virus (WNV) infection, 2 had sandfly fever virus-Naples (SFN), and 1 had sandfly fever virus-Sicilian (SFS) infection. SFN was isolated from the acute serum sample of 1 of the 2 patients with SFN infection.
Antivasospastic and antiinflammatory effects of caspase inhibitor in experimental subarachnoid hemorrhage (2007)

These results indicate that caspase activation may be involved in the development of SAH-induced vasospasm through inflammatory reaction.
Immunogenicity of the Influenza Vaccine in IBD Patients Treated with Vedolizumab (2018)

Introduction: Patients with Inflammatory Bowel Disease (IBD) are often treated with medications that suppress the immune system putting them at increased risk of vaccine-preventable infections. While inactivated vaccines have been shown to induce an immune response in IBD patients regardless of level of immunosuppression, some question does exist regarding the efficacy in IBD patients on therapies that impact global immune responses. Unlike biologic medications that target TNF-a resulting in systemic immunosuppression, vedolizumab targets the a4β7 integrin, which is expressed on inflammatory circulating lymphocytes to allow trafficking to the gut. Our aim was to determine immune response rates to the influenza vaccine in IBD patients receiving vedolizumab compared to patients on other therapies. Methods: Patients with IBD receiving care at Boston Medical Center were recruited to participate during routine office visits from 9/2017 - 4/2018 and divided into 3 study groups based on IBD therapy (Table 1). The 2017/2018 trivalent influenza vaccine was administered as determined by the patient's gastroenterologist. Serum was collected prior to vaccination and then again 3-4 weeks later; samples were analyzed for antibody titers by ELISA. Results: Across all study groups, 26 patients were identified who had pre and post vaccination serum samples. A high baseline titer was noted in all subjects regardless of study group or age, and no follow up titers met efficacy criteria of a 4-fold increase over baseline (Table 2). All subjects included had received an influenza vaccine in a flu season prior to 2017/2018, with the minimum number of previous influenza vaccines received being one and the maximum being eight. Conclusion: Vaccination is an important part of preventative care. Some immunosuppressive medications for IBD may impair immune response to vaccination. However, regardless of IBD therapy, patient's ability to induce a measurable humoral response to the influenza vaccine is likely impacted by previous annual vaccination and exposure history, evidenced by high baseline titers. These findings support that repeated vaccination contributes to a consistently seropositive state (Nunez IA, et al. 2017. PLoS ONE 12(11)). Studies are underway to measure the T cell response at baseline and follow-up. Further research examining the response to vaccination in IBD patients to vaccines that are not administered on an annual basis and thus have low baseline titers is also ongoing.730_A Figure 1 No Caption available.730_B Figure 2 No Caption available.
N-Substituted Piperidinyl Alkyl Imidazoles:  Discovery of Methimepip as a Potent and Selective Histamine H3 Receptor Agonist (2004)

In this study, we continue our efforts toward the development of potent and highly selective histamine H(3) receptor agonists. We introduced various alkyl or aryl alkyl groups on the piperidine nitrogen of the known H(3)/H(4) agonist immepip and its analogues (1-3a). We observed that N-methyl-substituted immepip (methimepip) exhibits high affinity and agonist activity at the human histamine H(3) receptor (pK(i) = 9.0 and pEC(50) = 9.5) with a 2000-fold selectivity at the human H(3) receptor over the human H(4) receptor and more than a 10000-fold selectivity over the human histamine H(1) and H(2) receptors. Methimepip was also very effective as an H(3) receptor agonist at the guinea pig ileum (pD(2) = 8.26). Moreover, in vivo microdialysis (in rat brain) showed that methimepip reduces the basal level of brain histamine to about 25% after a 5 mg/kg intraperitoneal administration.
Electrical Behavior of Molecular Junctions Incorporating α-Helical Peptide (2005)

We synthesized an alpha-helical peptide containing two terminal thiol groups and demonstrated the method of preparation of a self-assembled monolayer (SAM) on gold with uniform orientation of the molecules on the surface. The monolayers were employed as model systems for the investigations of mediated electron transfer. The measurements of electron transfer efficiency through the peptide were performed using scanning tunneling spectroscopy (STS). The molecules were trapped between the gold tip and the substrate using a Au-S linkage. The electron transfer behavior of the peptide was examined as a function of the tip-substrate distance at fixed bias voltage and as a function of bias voltage at a fixed distance between the tip and the substrate. The data obtained from these experiments indicated that the electron transfer through alpha-helical peptide is very efficient, and its conductivity is comparable to those observed for dodecanedithiol. There is also a directional dependence of electron transmission through the peptide, which is connected with the electric field generated by the molecular dipole of the helix.
Simulation of domain structure for magnetic thin film in an applied field (1990)

Domain structures in an applied field are simulated by minimizing the total energy in two dimensions. Wall positions and magnetization directions in the applied field are determined mainly by the balance of magnetostatic energy Es and Zeeman energy Em. On the other hand, the number of domains is determined by the balance of anisotropy energy and wall energy. Using this calculation, a soft magnetic film of low aspect ratio, such as a magnetic head core, is analyzed in the applied field. It was found that the energies Es and Em are seemed to be determined by the film shape independently of the number of domains, and the ratio of Es to Em is about 1 to −2. Moreover, the change in domain structure induced by applied field agrees with observations using a Kerr microscope. By analyzing a trapezoidal film which is similar to the thin-film head core, we can obtain the angle of the film side surface whose domain structure is stable.
Effect of adrenal manipulation on glucocorticoid receptors in MM1 hamster melanoma. (1982)

Cytosol glucocorticoid receptor of hamster Malignant Melanoma No. 1 (MM1) was characterized by dextran-coated charcoal and sucrose gradient assays. MM1 contains a specific, saturable, high-affinity (Kd 2.5 nM; 73.3 fmol/mg cytosol protein) receptor for glucocorticoid. The receptor sedimented at 7 to 8S in low-salt buffer and 5.5S in 0.4 M KCl and was sensitive to proteolysis by trypsin. Glucocorticoid receptor was inactivated by 40% (NH4)2SO4. Addition of 20 mM molybdate to the homogenizing buffer prevented inactivation. Adrenalectomy increased MM1 receptor content without altering affinity. Chronic exposure of intact or adrenalectomized hamsters to gluco- and high-dose mineralocorticoid significantly decreased the amount of unbound glucocorticoid receptors available for binding. Exposure of intact hamsters to high doses of mineralocorticoid also decreased apparent receptor affinity. These results suggest that hamster MM1 contains a high-affinity cytosol receptor for glucocorticoids similar to that of other glucocorticoid-responsive tissues, which may mediate the action of adrenal steroids on tumor behavior.
The Dynamics of a Bi-Stable Energy Harvester: Exploration via Slow-Fast Decomposition and Analytical Modeling (2012)

The paper discusses the advantages of the bi-stable energy harvester over linear oscillators in the low frequency excitation regime. When excited by low-frequency base motions, a bistable vibration-based energy harvester’s response is characterized by a combination of a slow, and a non-stationary fast component. By decomposing the response of the bi-stable system into fast and slow components, some new physical insights into the dynamical properties of the system are obtained. Properties such as mechanical frequency up-conversion, asymmetry in the bi-stable potential of the system and extraction of the backbone curve are explored. The proposed decomposition is demonstrated and explained via numerical and experimental results. A simple, approximate analytical model, for the bi-stable oscillator is proposed and its ability to detect migration towards different vibration regimes is illustrated. An expression for the power output of the harvester is derived from the analytical solution allowing us to tune the bi-stable potential towards optimum performance. The analytical model sheds light on the occurrences of bifurcations in the response of such nonlinear systems and on the optimal values of potential barrier vs. excitation levels.
Retrobulbar Optic Nerve Diameter Measured by High-Speed Magnetic Resonance Imaging as a Biomarker for Axonal Loss in Glaucomatous Optic Atrophy (2009)

Retina- or optic nerve head-related surrogate markers for axonal content correlated closely with the OND, although only when it was measured in the orbital apex. High-resolution MRI using an ultrafast HASTE-sequence at 3 T proved useful for OND quantification and may be a valuable asset in future neuroprotection trials.
Modification of the Estrogenic Properties of Diphenols by the Incorporation of Ferrocene. Generation of Antiproliferative Effects in Vitro (2005)

We report here the synthesis and the strong and unexpected antiproliferative effect of the organometallic diphenolic compound 1,1-bis(4'-hydroxyphenyl)-2-ferrocenyl-but-1-ene (4) on both hormone-dependent (MCF7) and -independent (MDA-MB231) breast cancer cells (IC(50) = 0.7 and 0.6 microM). Surprisingly, 6 [1,2-bis(4'-hydroxyphenyl)-2-ferrocenyl-but-1-ene], the regioisomer of 4, shows only a modest effect on these cell lines. This pertinent organometallic modification seems to trigger an intracellular oxidation of the structurally favorable compound 4, leading to the generation of a potent cytotoxic compound.
Hydrogels by supramolecular crosslinking of terpyridine end group functionalized 8-arm poly(ethylene glycol) (2014)

Metallo supramolecular assemblies of an 8-arm poly(ethylene glycol) partially substituted with terpyridyl end-groups and the transition metal ions Ni(2+), Fe(2+), Co(2+) and Zn(2+) were studied for their nano-particle formation at dilute conditions and gelation at higher concentrations. The large differences in dissociation rate constants of the metal ligand complexes largely determine the assembly behavior. Thermodynamically stable complexes are generated with Ni(2+) and Fe(2+) chlorides, which lead to distinct particle sizes of ∼200 nm in dilute conditions. The Co(2+) and Zn(2+) chlorides provide multiple size distributions revealing that mono and bis-complexes are present at equilibrium. Upon complexation, terpyridyl groups move to the outer sphere giving aggregates with a charged surface. At polymer concentrations above 5 wt%, crosslinking upon addition of transition metal ions provides hydrogels. Elastic hydrogels were obtained with Ni(2+), Fe(2+) and Co(2+) having storage moduli in excess of 20 kPa, whereas Zn(2+) gels are relatively viscous. Only Zn(2+) gels show a thermoreversible sol to gel transition at a temperature of 25 °C independent of polymer concentration.
Highly branched polymers (1992)

Well‐defined, large dendritic molecules with branches at almost every repeat unit have recently been shown to form ordered structures such as gels and liquid‐crystalline phases. The highly branched Highly Branched Polymers polyamide shown in the Figure forms, for example, a nematic phase as a 40 wt‐% solution in amides, and as a 60 wt‐% solution forms a gel static conditions but becomes fluid under shear stress. magnified image
Automated collection of double red blood cell units with a variable‐volume separation chamber (2007)

The Cymbal device provided quick and efficient collection of 2 RBC units with properties meeting regulatory requirements and consistent with good clinical utility.