gebhart/patrepeval huggingface dataset:
Optimal Ensemble Classifiers Based Classification for Automatic Vehicle Type Recognition (2018)

In this work, a challenging vehicle type classification problem for automatic toll collection task is considered, which is currently accomplished with an Optical Sensors (OS) and corrected manually. Indeed, the human operators are engaged to manually correct the OS misclassified vehicles by observing the images obtained from the camera. In this paper, we propose a novel vehicle classification algorithm, which first uses the camera images to obtain the vehicle class probabilities using several Convolutional Neural Networks (CNNs) models and then uses the Gradient Boosting based classifier to fuse the continuous class probabilities with the discrete class labels obtained from two optical sensors. We train and evaluate our method using a challenging dataset collected from the cameras of the toll collection points. Results show that our method performs significantly (98.22% compared to 75.11%) better than the existing automatic toll collection system and, hence will vastly reduce the workload of the human operators. Moreover, we provide an in-depth analysis w.r.t. the learning strategies:e.g., choice of the optimization algorithm of the CNN model. Our results and analysis highlights interesting perspectives and challenges for the future work.
Myocardial ??-adrenoceptors and left ventricular hypertrophy due to pressure overload in humans (1992)

Galinier, M*,†; Senard, J M*; Drean, G*; Valer, P*; Glock, Y‡; Dalous, Ph‡; Roux, D‡; Puel, J†; Montastruc, J L*; Bounhoure, J P† Author Information
Peripherally administered desacetyl α-MSH and α-MSH both influence postnatal rat growth and associated rat hypothalamic protein expression (2006)

Desacetyl alpha-MSH predominates over alpha-MSH during development, but whether it is biologically active and has a physiological role is unclear. We compared the effects of 0.3 microg.g(-1).day(-1) desacetyl alpha-MSH with that of 0.3 microg.g(-1).day(-1) alpha-MSH on postnatal body growth by administering the peptides subcutaneously daily for postnatal days 0-14 and also used a two-dimensional gel electrophoresis gel-based proteomic approach to analyze protein changes in hypothalami, the relay center for body weight and growth regulation, after 14 days of treatment. We found that the growth rate between days 1 and 10 was significantly decreased by desacetyl alpha-MSH but not by alpha-MSH, but by day 14, a time reported for development of a mature pattern of hypothalamic innervation, both peptides had significantly increased neonatal growth compared with PBS-treated control rats. Desacetyl alpha-MSH significantly increased spleen weight, but alpha-MSH had no effect. alpha-MSH significantly decreased kidney weight, but desacetyl alpha-MSH had no effect. Both desacetyl alpha-MSH and alpha-MSH significantly decreased brain weight. By 14 days, both peptides significantly changed expression of a number of hypothalamic proteins, specifically metabolic enzymes, cytoskeleton, signaling, and stress response proteins. We show that peripherally administered desacetyl alpha-MSH is biologically active and induces responses that can differ from those for alpha-MSH. In conclusion, desacetyl alpha-MSH appears to be an important regulator of neonatal rat growth.
Electrooptic Polymer Mach—Zehnder Modulators (1995)

Electro-Optic polymer Mach-Zehnder modulators are described with regard to design, fabrication, and testing at high operating speeds. The expected frequency response is discussed in terms of an electrical signal propagating co-linearly with an optical signal, as well as the conductivities of the electrodes. The effects of polymer conductivity and poling efficiency on modulator switching voltage are described. Modulators fabricated to have 5 V switching levels were tested using a bit error rate test system, and the results show excellent response times at a clock rate of 900 Mb/s. The response was limited by test equipment, and the actual performance is calculated to be significantly above the equipment limitations.
Arrayed waveguide grating based on group-index modification (2006)

The authors propose a new wavelength-dispersive principle based on waveguide group-index modification and apply this principle in a new type of arrayed waveguide dispersive element based on modified group index. The element is composed by an array of waveguides consisting of two sections with different group indexes. We deduce the applicable dispersion formula and demonstrate that the group-index modification can be used for controlling or enhancing device wavelength dispersion. Two device examples are provided. First, dispersive properties of a waveguide array with silicon on insulator (SOI) straight waveguides with group index modified by waveguide widening are calculated. Then, the authors show that by placing the element with modified group index in a phased array of a conventional arrayed waveguide grating (AWG) device, the dispersive properties of the AWG are markedly enhanced. Dispersion-enhancement factor of up to 60 is calculated for a compact demultiplexer designed for SOI platform with group index modified by photonic-bandgap effect
Extracorporeal shock-wave lithotripsy: long-term complications (1988)

Of 148 patients who had extracorporeal shock-wave lithotripsy (ESWL) for renal lithiasis in 1984, 21 (14%) returned after 17-21 months for renal function tests (21 patients) and blood pressure determination (20 patients). Quantitative radionuclide renography showed a statistically significant (p = .048) decrease in the percentage of effective renal plasma flow (ERPF) to the treated kidney. Two of these patients had developed hypertension requiring treatment but became normotensive when given medication. In the other patients there was a statistically significant increase in both systolic (p = .0002) and diastolic (p = .015) blood pressures. Information about blood pressure was also obtained from an additional 71 (48%) of the 148 patients; of the total 91 patients (61%) in whom blood pressures were obtained, seven (8%) had developed sufficiently severe hypertension to require treatment beginning within 21 months after ESWL. Side effects of ESWL for renal lithiasis include hemorrhage, edema, and acute tubular necrosis of the kidney. This form of renal trauma is associated with an immediate decrease in renal function of the treated kidney, and this decrease may be permanent. ESWL is also associated with the onset of hypertension, which may occur immediately or be delayed by several weeks or months. Although the pathogenesis remains unknown, hypertension is an important complication of ESWL in about 8% of patients.
Electrocatalyst Stability In PEMFCs And The Role Of Fuel Starvation And Cell Reversal Tolerant Anodes (2006)

Gross fuel starvation at the anode of a proton exchange membrane fuel cell (PEMFC) can result in cell reversal. High positive anode potentials are reached to sustain the current by water oxidation and carbon corrosion at the Pt based anode electrocatalysts. The membrane electrode assembly (MEA) is irreversibly damaged and the flow field plates and stack material in electrical contact with the MEA can be corroded. One of the best approaches to minimise the impact of fuel starvation is to build cell reversal tolerance into the MEA.Moving to more corrosion resistant carbon supports, adding Teflon to the anode catalyst layer to retain water, and deploying a water oxidation electrocatalyst in the anode significantly improved the cell reversal tolerance of the MEA.
Enucleation combined with hepatic vascular exclusion is a safe and effective alternative to hepatic resection for liver cell adenoma. (1994)

Liver cell adenomas are benign, rare tumors that occur primarily in women with a history of oral contraceptive use. Surgical treatment is recommended to reduce the risk of sudden, unpredictable hemorrhage or malignant transformation, but mortality rates of 5 to 8 per cent are reported for major hepatic resections. This report summarizes an experience of eight patients with liver cell adenoma treated by enucleation or resection, alone or combined with hepatic vascular exclusion (HVE). The latter technique, originally described in the mid-1960s, markedly reduces operative blood loss associated with hepatic resection. All eight patients were women of child-bearing age, and seven reported previous oral contraceptive use. The majority of patients were asymptomatic at the time of presentation. Six patients (75%) had a single adenoma and the remaining two had multiple lesions. HVE was used successfully in four patients with no perioperative mortality and reduced by nearly 50 per cent the intraoperative blood loss compared to conventional hepatic resection (1635 mL versus 3875 mL, respectively). Six evaluable patients were followed for an average of 65 months, with no evidence of liver dysfunction or adenoma recurrence. Enucleation of liver cell adenoma appears to be a safe alternative to formal hepatic resection and provides excellent long-term results. HVE markedly reduces operative blood loss, has no adverse effect on metabolic function, decreases the potential health risk associated with transfusion, and should be used whenever possible.
Engineering mammalian cell factories for improved recombinant monoclonal antibody production: lessons from nature? (2005)

In this review we consider how cell specific recombinant monoclonal antibody (Mab) production by engineered mammalian cells can be improved. Whilst it is generally recognized that Mab production is limited post-transcriptionally at folding and assembly reactions, genetic engineering strategies based on overexpression of individual chaperones or foldases in mammalian cells have not reliably increased cell specific Mab production. Given that recent studies have established that chaperones and foldases themselves exist in a large multiprotein complex, which may coordinate the sequential processing of Mabs, we propose that global expansion of all components of the secretory pathway will likely be necessary to generically improve recombinant Mab production by mammalian cells. In this context, what can be learnt from nature? Important recent studies have delineated some of the main cellular pathways involved in the differentiation of B-cells into nature's own high level Mab producers, plasma cells. This is achieved by a dramatic re-programming of cellular function where the coordinated expansion of metabolic and secretory machinery precedes Ig production, then is maintained by induction of a key intracellular signaling pathway, the unfolded protein response (UPR). Here we review genetic engineering strategies to increase cell specific production rate and discuss whether manipulation of intracellular signaling systems such as the UPR will provide a novel means to engineer mammalian cells for high level recombinant Mab production.
Poly(acrylic) nanocoatings deposited by AP-PECVD processes on paper substrates for packaging applications (2012)

Poly(acrylic acid) coatings on paper substrates have been prepared by atmospheric pressure plasma enhanced chemical vapor deposition (AP-PECVD). The structure/properties relationships of the samples were studied in dependence of the plasma experimental conditions. Acrylic acid monomer/helium ratio and treatment speed clearly influences the wettability properties of the paper substrate: advancing contact angle values were reduced to the half (around 60 o) if compare to non-treated paper (120 o approximately). The surface morphology of the films did not greatly vary with the plasma polymerization treatment.
Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice (2008)

Mitochondrial dysfunction in skeletal muscle has been implicated in the development of type 2 diabetes. However, whether these changes are a cause or a consequence of insulin resistance is not clear. We investigated the structure and function of muscle mitochondria during the development of insulin resistance and progression to diabetes in mice fed a high-fat, high-sucrose diet. Although 1 month of high-fat, high-sucrose diet feeding was sufficient to induce glucose intolerance, mice showed no evidence of mitochondrial dysfunction at this stage. However, an extended diet intervention induced a diabetic state in which we observed altered mitochondrial biogenesis, structure, and function in muscle tissue. We assessed the role of oxidative stress in the development of these mitochondrial abnormalities and found that diet-induced diabetic mice had an increase in ROS production in skeletal muscle. In addition, ROS production was associated with mitochondrial alterations in the muscle of hyperglycemic streptozotocin-treated mice, and normalization of glycemia or antioxidant treatment decreased muscle ROS production and restored mitochondrial integrity. Glucose- or lipid-induced ROS production resulted in mitochondrial alterations in muscle cells in vitro, and these effects were blocked by antioxidant treatment. These data suggest that mitochondrial alterations do not precede the onset of insulin resistance and result from increased ROS production in muscle in diet-induced diabetic mice.
Nanoparticle delivery of an AKT/PDK1 inhibitor improves the therapeutic effect in pancreatic cancer (2014)

Abstract: The K- ras mutation in pancreatic cancer can inhibit drug delivery and increase drug resistance. This is exemplified by the therapeutic effect of PH-427, a small molecule inhibitor of AKT/PDK1, which has shown a good therapeutic effect against a BxPC3 pancreatic cancer model that has K- ras , but has a poor therapeutic effect against a MiaPaCa-2 pancreatic cancer model with mutant K- ras . To increase the therapeutic effect of PH-427 against the MiaPaCa-2 pancreatic cancer model with mutant K- ras , we encapsulated PH-427 into poly(lactic-co-glycolic acid) nanoparticles (PNP) to form drug-loaded PH-427-PNP. PH-427 showed a biphasic release from PH-427-PNP over 30 days during studies in sodium phosphate buffer, and in vitro studies revealed that the PNP was rapidly internalized into MiaPaCa-2 tumor cells, suggesting that PNP can improve PH-427 delivery into cells harboring mutant K- ras . In vivo studies of an orthotopic MiaPaCa-2 pancreatic cancer model showed reduced tumor load with PH-427-PNP as compared with treatment using PH-427 alone or with no treatment. Ex vivo studies confirmed the in vivo results, suggesting that PNP can improve drug delivery to pancreatic cancer harboring mutant K- ras . Keywords: nanoparticles, pancreatic cancer, AKT, bioluminescence imaging, drug delivery
Adverse Events Involving Hallux Metatarsophalangeal Joint Implants: Comprehensive Analysis of US Food and Drug Administration Data from 2010 to 2018 (2020)

Category: Midfoot/Forefoot; Other Introduction/Purpose: The prevalence of osteoarthritis of the hallux metatarsophalangeal joint (MTPJ) is estimated to affect 1 in 40 people over the age of 50. Surgical treatment options for MTPJ arthritis include joint preservation, joint resurfacing, and salvage arthrodesis. Arthroplasty of the great toe MTPJ has evolved over the past several decades. The aims of this study were to examine the MAUDE database to determine reported adverse events for hallux MTPJ arthroplasty. Methods: The US Food and Drug Administration’s (FDA) Manufacturer and User Facility Device Experience (MAUDE) database was reviewed from 2010-2018 to determine reported adverse events for approved implants. We recorded and categorized the type of adverse event and excluded duplicate reports and those extracted from already published literature. Results: Among 64 unique hallux MTPJ implant adverse events, the most common modes of failure were component loosening (34%), component fracture (9.4%), inflammation (9.4%), infection (14.1%), and allergic reaction (7.8%). In regards to implant type, synthetic implants (Cartiva) had the highest percentage of adverse events (23.4%), followed by Arthrosurface ToeMotion (20.3%), Ascension MGT (12.5%), Arthrosurface HemiCAP (10.9%), Futura primus (9.4%), and Osteomed Reflexion (6.3%). The number of adverse events reported increased substantially after 2016. Conclusion: Our study of the MAUDE database demonstrated that component loosening and infection are the most common modes of adverse events for hallux MTPJ implants. Cartiva accounted for one-fourth of the implant-related adverse events during our study period, followed by ToeMotion and Ascension MGT implants. Given that the adverse events for hallux MTPJ implants are underreported, improved reporting mechanisms should be utilized to improve our understanding on long-term effects of various hallux MTPJ implants. [Table: see text]
Determination of immunoglobulin concentrations and genetic parameters for colostrum and calf serum in Charolais animals (2021)

Colostrum samples from 366 Charolais primiparous cows, as well as serum from their calves at 24 to 48 h of age, were collected to gain an overview of the situation regarding passive immune transfer in beef cattle, from both the phenotypic and genetic points of view. All samples were analyzed to quantify their G<sub>1</sub> immunoglobulins by radial immunodiffusion (RID) and their IgG, IgA, and IgM using ELISA. The average concentrations obtained in colostrum were 84 mg/mL for RID-IgG<sub>1</sub>, and 158 mg/mL, 4.5 mg/mL and 10.8 mg/mL for ELISA-IgG, -IgA, and -IgM, respectively. The corresponding values in calf serum were 19.9, 30.6, 1.0, and 1.9 mg/mL. Apart from the general environmental effect (farm-year combination and laboratory conditions), the characteristics of the dams tested did not reveal any influence on colostrum immunoglobulin concentrations. Calving difficulty, as well as the birth weight and sex of calves, were found to be associated with serum concentrations in some cases. Heritability estimates were low to moderate, with the highest being for RID-IgG<sub>1</sub> in colostrum (h<sup>2</sup> = 0.28, standard error = 0.14) and serum (h<sup>2</sup> = 0.36, standard error = 0.18). Phenotypic correlations among the different immunoglobulins were generally positive or null, and none of the genetic correlations were significant due to large standard errors. The phenotypic correlation between dam colostrum and calf serum values was 0.2 for RID-IgG<sub>1</sub> and null for the 3 ELISA measurements. The correlation between RID-IgG<sub>1</sub> and ELISA-IgG was, unexpectedly, null for colostrum and 0.4 for serum. Increased RID-IgG<sub>1</sub> levels in calf serum were associated with improved survival, as well as better early growth and fewer health problems. These results thus showed that despite generally higher concentrations in beef than in dairy cattle, passive transfer was unsuccessful in a considerable number of calves. This should be brought to the attention of breeders to avoid negative effects on survival and subsequent performance. The heritability estimates were encouraging; however, obtaining phenotypes on a large scale constitutes a real limitation regarding these traits.
The construction of new vehicles for the cloning of transcription termination signals (1981)

We have constructed new plasmids that can be used to clone transcription terminator containing DNA fragments between the first gene of the tryptophan (trp) operon and the tetracycline resistance (tet) gene. Both genes are under control of the trp promotor. Therefore the presence of a transcription termination signal on cloned fragments can be monitored by a decrease in expression of the tet gene. The plasmids contain cloning sites at different distances from the translation start signal. Consequently a cloned DNA fragment can be translated in the three possible reading frames, offering the opportunity to distinguish terminators from translation polarity (pseudo-terminators). The usefulness of the plasmids was shown by the cloning of the trp terminator and of a pseudo-terminator located in the trpB gene.
Anomaly detection in IP networks (2003)

Network anomaly detection is a vibrant research area. Researchers have approached this problem using various techniques such as artificial intelligence, machine learning, and state machine modeling. In this paper, we first review these anomaly detection methods and then describe in detail a statistical signal processing technique based on abrupt change detection. We show that this signal processing technique is effective at detecting several network anomalies. Case studies from real network data that demonstrate the power of the signal processing approach to network anomaly detection are presented. The application of signal processing techniques to this area is still in its infancy, and we believe that it has great potential to enhance the field, and thereby improve the reliability of IP networks.
Connecting the Kinetics and Energy Landscape of tRNA Translocation on the Ribosome (2013)

Functional rearrangements in biomolecular assemblies result from diffusion across an underlying energy landscape. While bulk kinetic measurements rely on discrete state-like approximations to the energy landscape, single-molecule methods can project the free energy onto specific coordinates. With measures of the diffusion, one may establish a quantitative bridge between state-like kinetic measurements and the continuous energy landscape. We used an all-atom molecular dynamics simulation of the 70S ribosome (2.1 million atoms; 1.3 microseconds) to provide this bridge for specific conformational events associated with the process of tRNA translocation. Starting from a pre-translocation configuration, we identified sets of residues that collectively undergo rotary rearrangements implicated in ribosome function. Estimates of the diffusion coefficients along these collective coordinates for translocation were then used to interconvert between experimental rates and measures of the energy landscape. This analysis, in conjunction with previously reported experimental rates of translocation, provides an upper-bound estimate of the free-energy barriers associated with translocation. While this analysis was performed for a particular kinetic scheme of translocation, the quantitative framework is general and may be applied to energetic and kinetic descriptions that include any number of intermediates and transition states.
<title>Microwave properties of the thermal metal-semiconductor transition of the polyaniline-VO<formula><inf><roman>2</roman></inf></formula> composites</title> (2000)

The purpose of this paper is to report the experimental results on polyaniline-VO<SUB>2</SUB> composites in the 45MHz-18GHz frequencies range versus temperature and VO<SUB>2</SUB> mass concentration. The temperature dependence studied by classical heating and courant pulse and the percolation phenomena study have been carried out in both the semi- conductor state and metallic state. The VO<SUB>2</SUB> metallic oxide is remarkable through a reversible discontinuity of the electric conductivity which can reach five orders of magnitude at a transition temperature generally located at 68 degree(s)C. This transition is associated with the modification from crystal structure VO<SUB>2</SUB> which passes from a quadratic structure (metal state) to a monoclinic structure (semiconductor state) at the temperature T<SUB>t</SUB>. The powder of VO<SUB>2</SUB> sintered in an induction oven. VO<SUB>2</SUB> was dispersed in a matrix of basic polyaniline, with mass rates of 10%, 30%, 50%, 70% and 90% of vanadium oxide. The strong dynamics of the composites beyond the threshold authorizes the use of a current to induce the temperature within the sample. The simulation of multi-layer of Jauman type, with commendable reflection and transmission in the frequencies range 8-12GHz will be shown.