gebhart/patrepeval huggingface dataset:
HEaRS: A Hierarchical Energy-Aware Resource Scheduler for Virtualized Data Centers (2011)

With the increasing popularity of Internet-based cloud services, energy efficiency in large-scale Internet data centers has become important not only to curtail energy costs and alleviate environmental concern, but also because such systems can quickly reach the limits of power available to them. This paper investigates to what extent and how energy usage improvements through consolidation can benefit from taking into account the environmental influences and effects seen in data center systems. Toward that end, we present experimental results obtained in a fully instrumented, small scale data center and then use these results to propose a hierarchical energy-aware resource scheduler (HEaRS) for cluster workload placement and server provisioning, also considers the physical environment in which data center systems operate. Specifically, at the rack level, HEaRS tries to maintain a 'thermal balance' across the rack to avoid hot spots and reduce cooling costs. At the chassis level, HEaRS utilizes the proportional plus integral controller to achieve a balance in the levels of usage of electrical current between the two power domains in the chassis, which helps the chassis reach its most energy efficient state. Finally, at server level, HEaRS can employ known methods like dynamic voltage and frequency scaling or core idling to reduce power consumption. This results in a hierarchical set of controllers that jointly, implement holistic solutions to energy-aware resource scheduling for an entire rack, and this hierarchical solution can then be further extended to entire data centers. Our initial experiment result show opportunities for gains, with up to 16% in energy usage compared to methods that are not aware of the physical environment and up to 15% improvements in application performance.
A Subset of Extreme Human Immunodeficiency Virus (HIV) Controllers Is Characterized by a Small HIV Blood Reservoir and a Weak T-Cell Activation Level (2017)

We suggest that an interesting HIC phenotype combines protective HLA alleles, low level of HIV blood reservoirs, and reduced immune activation. Prospective studies aimed at evaluating the benefit of combined antiretroviral therapy in HICs might take into account the identification of uHICs and bHICs.
Distribution of Bacteria in the Epidermal Layers and Hair Follicles of the Human Skin (2011)

Previous studies over recent years have revealed the presence of a resident bacterial population in the human skin throughout the entire body. However, the localization and composition of the bacteria within the epidermis and the skin appendages have not been fully investigated. Using differential tape stripping, cyanoacrylate skin surface biopsies and mapping of hair follicles, bacteria on the forearms of study participants were isolated, mapped, cultured and identified with respect to their origin within the epidermis and the hair follicles. Our studies showed that 85% of the bacteria were found within the first 6 corneocyte layers and roughly 25% of the cutaneous bacterial population were localized within the hair follicles. The microbial flora of the skin between individuals is subject to considerable fluctuations. Micrococcaceae represent the biggest fraction of hair-follicle-associated bacteria. The techniques developed for this study allowed us to selectively investigate the bacterial population within the hair follicles. Our results point out the role of skin appendages as potential microbial reservoirs and the need to develop new antiseptic formulations that sufficiently penetrate into the hair follicles.
Misleading tacrolimus concentration value in blood taken from a catheter used for tacrolimus administration (2008)

The collection of blood from a central venous catheter lumen that had been used for tacrolimus administration resulted in a BTC about eight times higher than what was measured in peripheral blood.
Computer extracted features of cancer nuclei from H&E stained tissues of tumor predicts response to nivolumab in non-small cell lung cancer. (2018)

12061 Background: Immune checkpoint inhibitors have recently been FDA-approved for use in advanced stage non-small cell lung cancer (NSCLC). These drugs target the PD-1 receptor or its ligand PD-L1, but treated patients only have a response rate of about 20%. It is thus crucial to identify which patients will derive maximal benefit from such treatments, especially since the current gold standard biomarker, detection of tissue-based PD-L1 expression, has been shown to be inadequate. Previous studies have shown that computer extracted features of nuclear shape and texture are predictive of recurrence in early stage NSCLC. The goal of this work is to evaluate the role of features of nuclei shape and arrangement in the tumor in predicting response to Nivolumab for NSCLC. Methods: The study included 56 patients with NSCLC from two different institutions who had had pre-treatment tumor biopsies and were treated with Nivolumab. The patients were split into two categories, responders and non-responders, that were determined by clinical improvement and radiologic assessment through RECIST criteria. The 245 features from tumor nuclei included standard measures used to characterize shape and texture of nuclei as well graph based features that capture the distinct spatial arrangement of the nuclei. Features were extracted from tumor regions manually annotated on digitized H&E images by two expert pathologists. Results: A statistical feature selection method determined the top five tumor nuclear features from the training set. These features included the spatial arrangement of nuclei and variance in nuclear shape and chromatin structure. A machine learning classifier trained with these top five features yielded an AUC = 0.65 on the training set (n = 32) and an AUC = 0.6 on the independent validation set from a separate institution. (n = 24). Conclusions: Computer extracted features of cancer nuclei were found to distinguish between patients who did and did not respond to Nivolumab immunotherapy. Validation is needed on larger cohorts from multiple different sites.
Cell-cycle fate-monitoring to identify individual chemosensitive and chemoresistant cancer cells in heterogeneous cancer populations. (2015)

e13514 Background: Essentially every population of cancer cells in a tumor or in culture is heterogeneous, especially with regard to chemosensitivity and resistance. Methods: In the present study, the fluorescent ubiquitination-based cell cycle indicator (FUCCI) imaging system was used to determine cell cycle behavior and apoptosis after treatment of cancer cells with chemotherapeutic drugs. HeLa cells expressing FUCCI were treated with doxorubicin (DOX) (5 μM) or cisplatinum (CDDP) (5 μM) for 3 h. Cell cycle progression and apoptotic changes were monitored by time-lapse FUCCI imaging for 72 h. Results: Time-lapse FUCCI imaging demonstrated that both DOX and CDDP could induce cell-cycle arrest in S/G2/M in most of the cells. However, a subpopulation of the cells could escape the block and undergo mitosis and subsequently underwent apoptosis while the cells arrested in S/G2/M survived. Conclusions: Chemoresistant cells can be readily identified in a heterogeneous population of cancer cells by S/G2/M arrest by FUCCI imaging which can be used to screen for novel agents that kill cell-cycle-arrested cells.
Conundrum, an ARHGAP18 orthologue, regulates RhoA and proliferation through interactions with Moesin (2013)

RhoA, a small GTPase, regulates epithelial integrity and morphogenesis by controlling filamentous actin assembly and actomyosin contractility. Another important cytoskeletal regulator, Moesin (Moe), an ezrin, radixin, and moesin (ERM) protein, has the ability to bind to and organize cortical F-actin, as well as the ability to regulate RhoA activity. ERM proteins have previously been shown to interact with both RhoGEF (guanine nucleotide exchange factors) and RhoGAP (GTPase activating proteins), proteins that control the activation state of RhoA, but the functions of these interactions remain unclear. We demonstrate that Moe interacts with an unusual RhoGAP, Conundrum (Conu), and recruits it to the cell cortex to negatively regulate RhoA activity. In addition, we show that cortically localized Conu can promote cell proliferation and that this function requires RhoGAP activity. Surprisingly, Conu's ability to promote growth also appears dependent on increased Rac activity. Our results reveal a molecular mechanism by which ERM proteins control RhoA activity and suggest a novel linkage between the small GTPases RhoA and Rac in growth control.
National survey of management of transient ischaemic attack in Australia: Take Immediate Action (2009)

Access to rapid assessment and management services for TIA varies considerably between Australian hospitals. The presence of organised stroke care at a hospital leads to improved processes of care for patients presenting with TIA.
Aglycon modifications of erythromycin A: regiospecific and stereospecific elaboration of the C-12 position (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAglycon modifications of erythromycin A: regiospecific and stereospecific elaboration of the C-12 positionJ. R. Hauske, M. Guadliana, G. Kostek, and Gayle SchulteCite this: J. Org. Chem. 1987, 52, 20, 4622–4625Publication Date (Print):October 1, 1987Publication History Published online1 May 2002Published inissue 1 October 1987https://doi.org/10.1021/jo00229a040RIGHTS & PERMISSIONSArticle Views131Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Role of buprenorphine in prolonging the duration of post-operative analgesia in percutaneous nephrolithotomy: Comparison between bupivacaine versus bupivacaine and buprenorphine combination (2015)

Peritubal infiltration of 0.25% bupivacaine with 100 μg buprenorphine around a nephrostomy tube increased the duration of analgesia following PCNL without any side-effects.
Oxygen Reduction on Supported Iridium Oxide Films in Neutral Phosphate Buffer: Implications for Neural Stimulation (2010)

Certain aspects of oxygen reduction on (hydrous) iridium oxide films deposited galvanostatically on smooth Au and glassy carbon (GC) electrodes have been examined in aqueous -saturated neutral phosphate buffer (pH 7) solutions. Regardless of the nature of the substrate, the onset potential for reduction, , as determined by cyclic voltammetry, was ca. −0.1 V vs saturated calomel electrode, which is very close to the corresponding found for both bare Au and GC electrodes. On this basis, the potential range in which the charge stored in the film is available for functional neural stimulation without generation of potentially harmful oxygen-derived species is on the order of 0.9 V. Studies involving a rotating Pt ring GC disk revealed that the reduction of dioxygen on yields predominantly hydrogen peroxide. Further measurements performed with a rotating GC disk showed that can oxidize hydrogen peroxide in the potential region associated with the more positive redox peak, a factor that might mitigate, at least in part, problems associated with the charge imbalance during the bipolar neural stimulation.
Early Experience with a Miniaturized Three-dimensional Matrix Transducer in Children (2006)

<p/>
Interactions of Chemokines and Chemokine Receptors Mediate the Migration of Mesenchymal Stem Cells to the Impaired Site in the Brain After Hypoglossal Nerve Injury (2004)

Mesenchymal stem cells (MSCs), cultured ex vivo, recently were shown to be able to migrate into sites of brain injuries when transplanted systemically or locally, suggesting that MSCs possess migratory capacity. However, the mechanisms underlying the migration of these cells remain unclear. In this study, we examined the role of some chemokines and their receptors in the trafficking of rat MSCs (rMSCs) in a rat model of left hypoglossal nerve injury. rMSCs transplanted into the lateral ventricles of the rat brain migrated to the avulsed hypoglossal nucleus, where the expression of chemokines, stromal-cell-derived factor 1 (SDF-1), and fractalkine was observed to be increased. This increase temporally paralleled the migration of rMSCs into the avulsed nucleus at 1 and 2 weeks after operation. It has been found that rMSCs express CXCR4 and CX3CR1, the respective receptors for SDF-1 and fractalkine, and other chemokine receptors, CCR2 and CCR5. Furthermore, in vitro analysis revealed that recombinant human SDF-1 alpha (rhSDF-1alpha) and recombinant rat fractalkine (rrfractalkine) induced the migration of rMSCs in a G-protein-dependent manner. Intracerebral injection of rhSDF-1alpha has also been shown to stimulate the homing of transplanted rMSCs to the site of injection in the brain. These data suggest that the interactions of fractalkine-CX3CR1 and SDF-1-CXCR4 could partially mediate the trafficking of transplanted rMSCs. This study provides an important insight into the understanding of the mechanisms governing the trafficking of transplanted rMSCs and also significantly expands the potential role of MSCs in cell therapy for brain injuries and diseases.
The masses of the mesons and baryons. Part I. The integer multiple rule (1999)

Koschmieder E. L., Koschmieder T. H. The masses of the mesons and baryons. Part I. The integer multiple rule. In: Bulletin de la Classe des sciences, tome 10, n°7-12, 1999. pp. 281-287.
Distributed resource allocation for femtocell interference coordination via power minimisation (2011)

This paper proposes a decentralized model for the allocation of modulation and coding schemes, subchannels and transmit power to users in OFDMA femtocell deployments. The proposed model does not rely on any exchanged information between cells, which is especially useful for femtocell networks. Coordination between femtocells is achieved through the intrinsic properties of minimising transmit power independently at each cell, which leads the network to self-organize into an efficient frequency reuse pattern. This paper also provides a two-level decomposition approach for solving this intricate resource assignment problem that is able to find optimal solutions at cell level in reduced periods of time. System-level simulations show a significant performance improvement in terms of user outages and network capacity when using the proposed distributed resource allocation in comparison with scheduling techniques based on uniform power distributions among subcarriers.
CIPC: For weed control in garlic (1965)

The herbicide CIPC, applied at 4 lbs per acre as a preemergence treatment for weed control in garlic, can be used safely in major production areas of California—and offers substantial savings over the usual cultivation and hand-weeding costs.
Transplantation of Genetically Modified Haematopoietic Stem Cells to Induce Antigen-Specific Tolerance as a Cure for Autoimmune Diseases (2011)

Autoimmune diseases are incurable and are managed using therapeutic agents. Bone marrow transplantation is being trialled as a treatment for these diseases. While allogeneic bone marrow transplantation shows impressive benefit, its application is hindered by GVHD and high mortality. On the other hand, autologous bone marrow transplantation has lower mortality rate and no GVHD but is associated with higher relapse rates. Given that autoimmune diseases are a result of a failure of immune tolerance and that bone marrow-derived dendritic cells play an important role in establishing immune tolerance, the transplantation of genetically modified haematopoietic stem cells to generate molecular chimerism to induce antigen-specific tolerance offers the potential for developing a cure for autoimmune diseases. In this review, we will discuss key findings from clinical data and animal studies to provide evidence to support the above concept.
Sequence-Dependent Effects in the Cyclization of Short DNA (2006)

A new, computationally efficient Monte Carlo approach has been developed to estimate the ring-closure properties of short, realistically modeled DNA chains. The double helix is treated at the level of base-pair steps using an elastic potential that accounts for the sequence-dependent variability in the intrinsic structure and elastic moduli of the base-pair steps, including the known coupling of conformational variables. Rather than using traditional Metropolis-Monte Carlo techniques to generate representative configurations, a Gaussian sampling method is introduced to construct three-dimensional structures from linear combinations of the rigid-body parameters defining the relative orientation and displacement of successive base pairs. The computation of the J factor, the well-known ratio of the equilibrium constants for cyclization vs bimolecular association of a linear molecule, takes into account restrictions on the displacement and directions of the base pairs joined in ring closure, including the probability that the end-to-end vector is null and the terminal base pairs coincide. The increased sample sizes needed to assess the likelihood that very short chains satisfy these criteria are attained using the Alexandrowicz half-chain sampling enhancement technique in combination with selective linkage of the two-half-chain segments. The method is used to investigate the cyclization properties of arbitrary-length DNA with greatly enhanced sampling sizes, i.e., O(10(14)) configurations, and to estimate J factors lower than 0.1 pM with high accuracy. The methodology has been checked against classic theoretical predictions of the cyclization properties of an ideal, inextensible, naturally straight, DNA elastic rod and then applied to investigate the extent to which one can account for the unexpectedly large J factors of short DNA chains without the need to invoke significant distortions of double helical structure. Several well-known structural features of DNA [Formula: see text] including the presence of intrinsic curvature, roll-twist coupling, or enhanced pyrimidine-purine deformability [Formula: see text] bring the computed J factors in line with the observed data. Moreover, periodically distributed roll-twist coupling reduces the magnitude of oscillations in J, seen in plots of J vs chain length, to the extent found experimentally.
Effect of Surface Morphology on Ferroelectric Domain Configuration (2006)

The effects of surface morphology on domain formation and relaxation in ferroelectric materials have been investigated. Comparison of the topography of triglycine sulfate with its ferroelectric domain image reveals a deterministic behavior in the formation of the equilibrium domain configuration. It is observed that defects such as crystal imperfections, cleavage steps and strained lines make ferroelectric state more stable by suppressing short-range repulsion, which results in domain pinning. On the other hand, it can be seen that long-range interaction is screened by free carriers in the metallic film. For this reason, we can see the domain movement beneath the metallic film is faster than that in bare surface.
Vortex-model-based Multi-objective Optimization of Winglets for Wind Turbines using Machine Learning (2022)

Abstract Different Design Driving Load constraints (DDLs), are explored in this work to determine under which constraints and conditions a winglet can have an added value to the wind turbine blade design. Multi-objective Bayesian optimization is used to maximize the rotor’s power production while minimizing the flapwise DDLs. Surrogate models, created using machine learning techniques such as Gaussian Processes and Bayesian Neural Networks, are used in combination with an acquisition function, to determine what designs should be evaluated by the lifting line model AWSM, with the goal to obtain designs that lie on the Pareto front of two or more objectives. The recent Bayesian Neural Networks as surrogate model were able to find the Pareto-front most effectively in this work. Furthermore, the results show that different DDL constraints led to different winglet designs, with noticeable differences between upwind and downwind winglet designs. Winglet designs were found to be able to increase power without increasing the thrust, root flapwise bending moment and flapwise bending moment at radial locations on the blade. A noticeable increase in power was found when introducing sweep to the winglet design.
Improved execution times by specialized data-structures and algorithms for scheduling problems (2013)

Improved execution times by specialized data-structures and algorithms for scheduling problems (Pieter Audenaert, Didier Colle, Mario Pickavet and Piet Demeester) Many sport scheduling problems are formulated as an optimization problem and solved by common operations research techniques like for example linear programming.To that aim, optimization software packages that implement generic solving strategies like the simplex method are widely used.However, by the very fact of using a generic approach to the problem, domain-specific knowledge is not exploited to its full extent.A contrasting approach is to take advantage of this additional circumstantial data and put it to good use, which directly leads to faster execution times than those obtained with classical operations research techniques.In this paper, we introduce some of the more esoteric data-structures and algorithms that are especially useful for efficient sport scheduling.When applied balanced, a finetuned special-purpose implementation can lead to faster execution times for selected problems.
Evaluation of population impact of candidate polymorphisms for coronary heart disease in the Framingham Heart Study Offspring Cohort (2009)

In order to evaluate the population impact of putative causal genetic variants over the life course of disease, we extended the static estimation of population-attributable risk fraction and developed a novel tool to evaluate how the population impact changes over time using the Framingham Heart Study Offspring Cohort data provided to the Genetic Analysis Workshop 16, Problem 2. A set of population-attributable risk fractions based on survival functions were estimated under the proportional hazards models. The development of this novel measure of population impact creates a more comprehensive estimate of population impact over the life course of disease, which may help us to better understand genetic susceptibility at the population level.