gebhart/patrepeval huggingface dataset:
Time reversal : impact on the performance of an UWB location system (2009)

This paper deals with the impact of the Time Reversal (TR) processing on the performance of an Ultra Wide Band (UWB) location system. In a first part, we describe the topology of the UWB location system we have developed. In a second part, we present the enhancement of UWB radio channel characteristics by applying a TR algorithm. We have considered an impulse response of the (UWB) radio channel corresponding to severe propagation conditions: TR signal processing is described and its benefits on the characteristics of the UWB Channel Impulse Response (CIR) are detailed. A third part presents first results on the reduction of the error location due to UWB multipath propagation.
The Kinetics of Cardiopulmonary Bypass: A Dual‐Platform Proteomics Study of Plasma Biomarkers in Pediatric Patients Undergoing Cardiopulmonary Bypass (2012)

This study was designed to investigate the expression kinetics and patterns of plasma biomarkers throughout the pediatric cardiopulmonary bypass (CPB) procedure to help predict those patients most at risk for complications. This study sampled plasma from pediatric CPB patients at five time points before, during, and after CPB. A dual-platform proteomics approach was then utilized which incorporated two-dimensional difference gel electrophoresis (2D-DIGE) coupled with matrix-assisted laser desorption ionization-time-of-flight/time-of-flight tandem mass spectrometry, and multi-analyte profile (MAP) assays to identify changes in expression of plasma protein biomarkers and characterize the patterns of these changes. A combined total of 134 proteins were identified with significant changes between the two platforms, with 53 coming from 2D-DIGE, 90 from MAP, and nine proteins that were identified using both methods. The proteins were then divided into 12 major groups based on the expression patterns, and two of the most clinically relevant proteins having the greatest changes in expression were selected from each group to use as "predictor biomarkers." A potential model for prediction of patient outcome was then generated using these 24 proteins. The patterns of biomarker expression during pediatric CPB may provide insight into the prediction, prevention, or treatment of complications resulting from CPB, thereby helping to improve the outcomes of pediatric CPB patients and reduce the incidence of complications.
Mutational analysis of parasite trypanothione reductase: acquisition of glutathione reductase activity in a triple mutant (1991)

African trypanosomes contain a cyclic derivative of oxidized glutathione, N1,N8-bis(glutathionyl)spermidine, termed trypanothione. This is the substrate for the parasite enzyme trypanothione reductase, a key enzyme in disulfide/dithiol redox balance and a target enzyme for trypanocidal therapy. Trypanothione reductase from these and related trypanosomatid parasites is structurally homologous to host glutathione reductase but the two enzymes show mutually exclusive substrate specificities. To assess the basis of host vs parasite enzyme recognition for their disulfide substrates, the interaction of bound glutathione with active-site residues in human red cell glutathione reductase as defined by prior X-ray analysis was used as the starting point for mutagenesis of three residues in trypanothione reductase from Trypanosoma congolense, a cattle parasite. Mutation of three residues radically alters enzyme specificity and permits acquisition of glutathione reductase activity at levels 10(4) higher than in wild-type trypanothione reductase.
Extrafine beclomethasone dipropionate breath-actuated inhaler (400 micrograms/day) versus budesonide dry powder inhaler (800 micrograms/day) in asthma. (2001)

Hydrofluoroalkane-134a beclomethasone dipropionate extrafine aerosol breath-actuated inhaler (Qvar Autohaler; BDP-AH) provides an alternative to chlorofluorocarbon metered dose inhalers or dry powder inhalers (DPIs). The aim of this six-week, open-label study was to determine whether BDP-AH demonstrates equivalent asthma control to twice the dose of budesonide (BUD)-DPI (Pulmicort Turbuhaler). Adults with symptomatic asthma inadequately controlled on BUD-DPI 400 micrograms/day and beta-agonist were enrolled. Patients (n = 193) were randomised to receive 400 micrograms/day BDP-AH (n = 98) (two puffs of 100 micrograms/actuation inhaler twice daily) or 800 micrograms/day BUD-DPI (n = 95) (two puffs of 200 micrograms/actuation inhaler twice daily). Both groups showed a statistically significant change from baseline in morning (a.m.) peak expiratory flow (PEF) at weeks 5-6 (p < 0.01), indicating study treatment improved a.m. PEF over prestudy 400 micrograms/day BUD. Changes from baseline in a.m. PEF at weeks 5-6 were 15.9 l/min for BDP-AH and 14.2 l/min for BUD-DPI; the groups were statistically equivalent (90% CI -7.02-10.44; p < -0.001 [equivalence = within +/- 25 l/min]). Other efficacy assessments (evening PEF, FEV1, asthma symptoms, beta-agonist use) confirmed the treatments were clinically equivalent. Thirty-nine (40%) patients on BDP-AH and 35 (37%) on BUD-DPI experienced at least one adverse event (p = 0.767). Four (4%) patients on BDP-AH and 3 (3%) on BUD-DPI reported increased asthma symptoms. BDP-AH at half the daily dose provided equivalent asthma control to BUD-DPI; both treatments were well tolerated.
Developing Social Applications in SAPERE (2013)

A number of recent pervasive computing applications are referred as "social" in that they operate by exchanging and aggregating user profiles to provide highly-contextualized information. To support the development of such applications it is important to rely on a proper model and infrastructure taking care of basic operations like profile aggregation and exchange, and providing an overall sound environment in which to design applications. In this paper we illustrate how to code an exemplary social application by means of the SAPERE framework and we discuss the advantages of such an approach. We also present experiments to assess the adoption of such a platform.
Concomitant <i>Mycobacterium tuberculosis</i>and <i>Aspergillus niger</i> Infection in a Patient with Acute Myeloid Leukemia (2003)

Primary cutaneous infection by Aspergillus spp. is an uncommon form of aspergillosis in patients with severe immunosuppression, e.g. patients with HIV infection or hematological malignancies. Disruption of the dermal integrity by trauma or maceration, followed by colonization of the wound by Aspergillus spp. creates a suitable environment for cutaneous infection. Despite aggressive therapy with amphotericin, primary cutaneous aspergillosis can lead to disseminated disease with fatal consequences. Tuberculosis is another rare infection in patients with hematological malignancies, but when present it is usually disseminated. We present a 46-year-old woman with acute myeloid leukemia who developed concomitantly Mycobacterium tuberculosis and Aspergillus niger infection. Cutaneous aspergillosis was diagnosed during neutropenia after induction therapy, which later became disseminated disease during antifungal therapy. Tuberculosis infection was diagnosed in a scalene lymph node biopsy specimen. The patient achieved remission of her underlying disease and responded very well to antituberculous and antifungal therapy.
Addressing the Challenges of High‐Throughput Cancer Tissue Proteomics for Clinical Application: ProCan (2019)

The cancer tissue proteome has enormous potential as a source of novel predictive biomarkers in oncology. Progress in the development of mass spectrometry (MS)-based tissue proteomics now presents an opportunity to exploit this by applying the strategies of comprehensive molecular profiling and big-data analytics that are refined in other fields of 'omics research. ProCan (ProCan is a registered trademark) is a program aiming to generate high-quality tissue proteomic data across a broad spectrum of cancer types. It is based on data-independent acquisition-MS proteomic analysis of annotated tissue samples sourced through collaboration with expert clinical and cancer research groups. The practical requirements of a high-throughput translational research program have shaped the approach that ProCan is taking to address challenges in study design, sample preparation, raw data acquisition, and data analysis. The ultimate goal is to establish a large proteomics knowledge-base that, in combination with other cancer 'omics data, will accelerate cancer research.
Photooxidation Analysis of Two Isomeric Nonfullerene Acceptors: A Systematic Study of Conformational, Morphological, and Environmental Factors (2021)

Despite the striking progress toward improving the efficiencies of organic solar cells (OSCs) resulting from the development of nonfullerene acceptors (NFAs), there is a rising requirement of investigation of the molecular design for achieving photochemically stable NFAs. Herein, applying two isomeric NFA molecules a ‐IDTBTRh and l ‐IDTBTRh based on angular‐indaceno[2,1‐ b :6,5‐ b ′]dithiophene ( a ‐IDT) and linear‐IDT ( l ‐IDT) as the central cores, the effects of molecular conformation, aggregation behavior, and environmental factors on their photooxidation degradation processes are systematically studied. It is found that tuning regioisomeric central cores on the molecular skeleton influences the backbone conformation and conjugation, resulting in the different optoelectronic properties and molecular stacking characteristics. A strong molecular aggregation dependence of the optical losses and degradation mechanics in the annealed neat films is also observed, and it is shown that l ‐IDTBTRh is much more photostable than its less‐ordered core derivative, a ‐IDTBTRh. Furthermore, the effects of external environmental stresses on photobleaching behaviors of the annealed thin films are studied systematically, highlighting the role of concentrated light in accelerating photooxidation of organic materials. The results not only provide a comprehensive insight into the photooxidation properties and attenuation mechanisms of organic materials, but also suggest guidelines to rationally select materials for stable OSCs.
Speaker adaptation and the evaluation of speaker similarity in the EMIME speech-to-speech translation project (2010)

This paper provides an overview of speaker adaptation research carried out in the EMIME speech-to-speech translation (S2ST) project. We focus on how speaker adaptation transforms can be learned from speech in one language and applied to the acoustic models of another language. The adaptation is transferred across languages and/or from recognition models to synthesis models. The various approaches investigated can all be viewed as a process in which a mapping is defined in terms of either acoustic model states or linguistic units. The mapping is used to transfer either speech data or adaptation transforms between the two models. Because the success of speaker adaptation in text-to-speech synthesis is measured by judging speaker similarity, we also discuss issues concerning evaluation of speaker similarity in an S2ST scenario.
Effective Puncturing Schemes for Block-type Low-Density Parity-Check Codes (2007)

In this paper, a puncturing method for block-type rate-compatible low-density parity-check (LDPC) codes with 'good' performance is proposed. Puncturing is a scheme to obtain a series of higher rate codes from a low rate mother code. It is widely used in channel coding but it causes performance loss compared with non-punctured error correcting codes at the same rate. There have been many researches about puncturing to reduce the performance loss. However, these researches are not optimized for specific types such as block-type LDPC (B-LDPC) codes adopted in IEEE 802.16e standards. B-LDPC codes are constructed as irregular quasi-cyclic LDPC (QC-LDPC) codes for reduced required memory size and efficient encoding. In this paper, we suggest a modified puncturing scheme which is optimized for B-LDPC codes and compare the performance with previous scheme.
Reading comprehension guessing strategies of Korean-speaking learners of Japanese (2021)

일본어 학습자는 일본어 문장을 읽다가 이해가 가지 않는 부분이 있을 때 한자의 개별 의미를 토대로 어구의 의미를 추측하기도 하고 앞뒤 문맥을 토대로 문장의 의미를 추측하기도 한다.<BR> 이 논문에서는 한국어를 모어로 사용하는 일본어 학습자가 일본어 문장을 읽을 시에 잘 모르는 부분의 의미를 어떻게 추측하고 있는지를 조사하였다.그 결과,학습자는 다음 네 종류의 방법에 기반하여 의미를 추측하고 있음을 확인하였다.이러한 네 종류의 방법에는 공통적으로 성공사례와 실패사례가 혼재되어 있었다.<BR> (1) 개별 문자를 이용한 추측: 예를 들어 ｢受け入れ｣의 의미를 모를 때, 자신이 알고 있는 한자 ｢入｣의 의미를 이용하여 ｢受け入れ｣를｢받아들이다｣라고 추측하는 경우이다.<BR> (2) 연관된 단어를 이용한 추측:예를 들어 ｢牛耳る｣의 의미를 모를 때, 자신이 알고 있는 단어｢エリート層｣가 ｢パリの政治経済を牛耳る｣의 주어인 것을 이용하여 ｢牛耳る｣의 의미를 ｢좌지우지한다｣라고 추측하는 경우이다.<BR> (3) 문법을 이용한 추측: 예를 들어 ｢認められません｣의 의미를 모를 때, 자신이 알고 있는 부정의 뜻을 나타내는 문법인 ｢ません｣을 이용하여 ｢認められません｣의 의미를 ｢안 된다｣라고 추측하는 경우이다.<BR> (4) 맥락을 이용한 추측: 예를 들어 ｢頭を下げました｣의 의미를 모를 때,자신이 알고 있는 사죄의 표현인 ｢申し訳ないけれど｣가 나오는 맥락을 이용하여｢頭を下げました｣의 의미를 ｢사죄했다｣라고 추측하는 경우이다.
Spectral efficiency of M-QAM in frequency reuse radio systems (1992)

The spectral efficiency of M-QAM modulation has been investigated for frequency reuse radio systems under the propagation conditions of the land mobile radio environment. The results indicate that, under certain circumstances (of propagation and coverage requirements), increasing the number of levels can lead to an improvement in the spectral efficiency of interference limited systems, but that, as better coverage or service quality is sought, these spectral efficiency improvements diminish.
Cubic and Spherical High-Moment FeCo Nanoparticles With Narrow Size Distribution (2007)

FeCo nanoparticles with controllable shapes and narrow size distribution were fabricated by using a plasma-gas-condensation technique. Either cubic shape or spherical shape were obtained when the magnetic field distribution above the sputtering target were well controlled. Meanwhile, the size distribution of these FeCo nanoparticles was also controllable, and a narrow size distribution of 4.9% was obtained at the optimized conditions. The Fe-Co nanoparticles with different shapes showed different magnetic behaviors.
Interface Currents: Supporting Co-Located Collaborative Work on Tabletop Displays (2005)

Large screen vertical and horizontal displays provide new opportunities to support individual and collaborative activities especially in terms of creativity and design tasks. The size of these displays introduces several unique opportunities such as co-located collaboration but at the same time issues for interface designers such as: potential difficulties of reaching workspace items far away from one s current position at the display, and the tendency of people to walk around when using a wall display or sit in various positions around a tabletop display. Thus, in contrast to traditional interfaces, large display interfaces need to support access to workspace items from a variety of positions at the display. In order to improve access to workspace items, providing better support for obtaining and sharing items and for mobility at the display which can be very important to improve creative processes, we propose a novel interaction metaphor, the so-called Interface Current, that allows interface components to play a more active role in the workspace activity.
Substitutions in interferon sensitivity‐determining region and hepatocarcinogenesis after hepatitis C virus eradication (2018)

Amino-acid substitutions in the ISDR are useful to predict not only IFN responsiveness but also HCC development in patients who achieved SVR by IFN-based therapy.
Predictions of molecular chirality and helical twisting powers: A theoretical study (2003)

A theoretical study of a number of chiral molecules has been undertaken using a molecular Monte Carlo simulation approach coupled with calculations of molecular chirality based on a chirality order parameter. Results for a variety of TADDOL (α,α,α′,α′-tetraaryl-1,3-dioxolan-4,5dimethanol) derivatives show good agreement with experimental findings for the sign, magnitude, and the temperature dependence of the helical twisting power (HTP). For a photochromic chiral dopant with variable HTP we are able to model the reduction in the HTP when photoisomerization occurs. Our studies on a liquid crystalline material with a single chiral center have reproduced a temperature dependent twist inversion in the material. We discuss the temperature and solvent dependence of the helical twisting power and argue that in all the systems studied here, preferential selection of certain molecular conformations at different temperatures and in different solvents are able to explain the observed experimental behavior of the HTP.
Genome sequence for the blue‐flowered Andean shrub Iochroma cyaneum reveals extensive discordance across the berry clade of Solanaceae (2022)

The tomato (Solanum lycopersicum L.) family, Solanaceae, is a model clade for a wide range of applied and basic research questions. Currently, reference-quality genomes are available for over 30 species from seven genera, and these include numerous crops as well as wild species [e.g., Jaltomata sinuosa (Miers) Mione and Nicotiana attenuata Torr. ex S. Watson]. Here we present the genome of the showy-flowered Andean shrub Iochroma cyaneum (Lindl.) M. L. Green, a woody lineage from the tomatillo (Physalis philadelphica Lam.) subfamily Physalideae. The assembled size of the genome (2.7 Gb) is more similar in size to pepper (Capsicum annuum L.) (2.6 Gb) than to other sequenced diploid members of the berry clade of Solanaceae [e.g., potato (Solanum tuberosum L.), tomato, and Jaltomata]. Our assembly recovers 92% of the conserved orthologous set, suggesting a nearly complete genome for this species. Most of the genomic content is repetitive (69%), with Gypsy elements alone accounting for 52% of the genome. Despite the large amount of repetitive content, most of the 12 I. cyaneum chromosomes are highly syntenic with tomato. Bayesian concordance analysis provides strong support for the berry clade, including I. cyaneum, but reveals extensive discordance along the backbone, with placement of chili pepper and Jaltomata being highly variable across gene trees. The I. cyaneum genome contributes to a growing wealth of genomic resources in Solanaceae and underscores the need for expanded sampling of diverse berry genomes to dissect major morphological transitions.
Alkaline phosphatase localization and spheroplast formation of Pseudomonas aeruginosa (1970)

Pseudomonas aeruginosa cells grown in the presence of low levels of inorganic phosphate contain an inducible alkaline phosphatase system. The enzyme has been localized by electron microscopic techniques in the region between the cytoplasmic membrane and the tripartite layer of the cell wall, i.e. the periplasmic space. No deposits of lead salts are observed upon examination of either uninduced cells or cells in which the enzyme has been completely removed by 0.2 M magnesium washing. Samples of cells which were treated with glutaraldehyde before enzyme localization studies show cell wall deposition of lead salts which could give rise to the erroneous conclusion that the alkaline phosphatase was located in the tripartite layer. Cytochemical and biochemical studies are presented which show that discontinuities within the cell wall are insufficient to account for the release of this periplasmic enzyme and that dissociation by a divalent metal, increased pH, or both is required. As a consequence of this study it was possible to prepare true spheroplasts of P. aeruginosa.
Exosome-associated Shiga toxin 2 is released from cells and causes severe toxicity in mice (2018)

Shiga toxin (Stx), a major virulence factor of enterohemorrhagic Escherichia coli (EHEC), is classified into two subgroups, Stx1 and Stx2. Clinical data clearly indicate that Stx2 is associated with more severe toxicity than Stx1, but the molecular mechanism underlying this difference is not fully understood. Here, we found that after being incorporated into target cells, Stx2, can be transported by recycling endosomes, as well as via the regular retrograde transport pathway. However, transport via recycling endosome did not occur with Stx1. We also found that Stx2 is actively released from cells in a receptor-recognizing B-subunit dependent manner. Part of the released Stx2 is associated with microvesicles, including exosome markers (referred to as exo-Stx2), whose origin is in the multivesicular bodies that formed from late/recycling endosomes. Finally, intravenous administration of exo-Stx2 to mice causes more lethality and tissue damage, especially severe renal dysfunction and tubular epithelial cell damage, compared to a free form of Stx2. Thus, the formation of exo-Stx2 might contribute to the severity of Stx2 in vivo, suggesting new therapeutic strategies against EHEC infections.
Report: Atmospheric pollutants discharged from municipal solid waste incineration and gasification-melting facilities in Japan (2009)

This article reports on the discharge of particulate matter, acid gases, nitrogen oxides, and dioxins from 107 municipal solid waste incineration and gasification-melting facilities in Japan between the years 2001 and 2003; the pollution control methods and the operational data are summarized. The knowledge on amounts of slaked lime used and the emission of acid gases is reported, the emission concentrations did not exceed the limit values in all facilities. In Japan, the regulation of dioxin emissions by the revised Waste Management and Public Cleansing Law (Ministry of the Environment, Government of Japan 2007) has been enforced since December 1997. Bag filters have been installed in all facilities constructed after this time, and catalytic reactors have been installed in 66% of these facilities. The regulated values for combustion temperature, the cooling temperature of gases discharged from furnaces and the concentration of carbon monoxide in the gases discharged from stacks were satisfactory in almost all facilities. In facilities constructed since December 1997, the dioxin concentrations in the discharged gases were considerably lower than in those constructed before this time. All facilities met the emission limit values for particulate matter, acid gases, nitrogen oxides and dioxins.
SSZ-33:  A Promising Material for Use as a Hydrocarbon Trap (2004)

SSZ-33 is tested for possible application as a hydrocarbon trap by investigating the temperature-programmed desorption behavior of toluene (used as a probe molecule) and the results are compared to those obtained with zeolites β, Y, mordenite, and ZSM-5. SSZ-33 shows higher adsorption capacity than the other zeolites at the conditions used here, and as well as better hydrothermal stability than zeolite β, and is therefore identified as a promising candidate for use as a hydrocarbon trap in cold-start emission control.
Therapeutic potential of human elafin (2011)

Elafin is an endogenous human protein composed of an N-terminal transglutaminase substrate motif and a C-terminal WAP (whey acidic protein)-domain with antiproteolytic properties. Elafin is expressed predominantly in epithelial tissue and potently inhibits the neutrophil-derived serine proteases elastase and proteinase-3 by a competitive tight-binding mechanism. Furthermore, it inhibits EVE (endogenous vascular elastase). Studies on several animal models show that antiprotease augmentation with human elafin is an effective strategy in the treatment of inflammatory vascular, systemic and pulmonary diseases and of inflammation triggered by reperfusion injury. This raises the possibility that elafin might be effective in the treatment of a variety of human inflammatory diseases. In a Phase I clinical trial, elafin was well tolerated. Phase II trials are underway to investigate the therapeutic effects of elafin on post-operative inflammation and the clinical consequences of major surgery. Of particular interest is the reduction of post-operative morbidity after oesophagus cancer surgery, coronary artery bypass surgery and kidney transplantation.