gebhart/patrepeval huggingface dataset:
In vitro and in vivo effects of KT6352, a derivative of indolocarbazole compounds, on murine megakaryocytopoiesis. (1998)

We investigated the in vitro and in vivo effects of KT6352, a derivative of indolocarbazole compound, on murine megakaryocytopoiesis. When serum-free megakaryocyte (Meg) colony assay was performed with 100 U/mL of recombinant mouse interleukin-3 (rmIL-3), the addition of 1x10(-11)M to 1x10(-9)M of KT6352 increased the number of Meg colonies. An additional increase of Meg colonies by KT6352 was observed in the serum-free culture containing rmIL-3 plus recombinant mouse interleukin-6 or rmIL-3 plus recombinant mouse stem cell factor. KT6352 did not stimulate Meg colony formation without rmIL-3. When KT6352 was administered intraperitoneally to normal BALB/c male mice at a dose of 10 mg/kg daily for 5 consecutive days, a 2.1-fold increase in the platelet count was observed on day 14, and the prolonged thrombocytopoiesis was detectable from 9 to 27 days after KT6352 administration. A marked increase in the white blood cell count was also observed from 5 to 14 days after KT6352 treatment. Before the gradual increase of platelet counts, 8 days after KT6352 administration, a marked increase in the number of colony-forming units of megakaryocytes (CFU-Megs) in bone marrow and spleen was observed, and a substantial increase in the number of splenic CFU-Megs was observed 14 and 23 days after KT6352 administration. Bone marrow Meg ploidy analysis by two-color flow cytometry showed a shift in the modal ploidy class from 16 to 32 and an increase in the frequency of 64 cells in KT6352-treated mice. These results suggest a possible therapeutic benefit of KT6352 in the management of thrombocytopenia.
On the use of Probabilistic Parallel Bit-Flipping decoder for the storage systems (2018)

The soft-decision Low-Density Parity-Check (LDPC) decoders have been applied in several storage systems thanks to their powerful error correction capability. However, these systems may suffer a long read latency since the soft-decision decoders require an intensive computations as well as a long sensing time for the soft-information before decoding. In this paper, we modify the recent-introduced Probabilistic Parallel Bit-Flipping (PPBF) LDPC decoder, to use on the storage systems in replacing the soft decision decoders, to improve the memory reading speed. The modified decoder is named Non-Syndrome Probabilistic Parallel Bit-Flipping (NS-PPBF). A special flipping mechanism is introduced such that the decoder can stop flipping without requiring the syndrome check results, which helps significantly improve the decoding frequency. We provide also the hardware architecture to implement NS-PPBF on the LDPC code used on the memory systems, which are usually very long block length with very high rate. The advantages of using NS-PPBF decoder in terms of error correction and decoding throughput are confirmed by the simulating decoding performance and the hardware synthesis.
Classification of human moving patterns using air pressure and acceleration (2002)

A new method to classify human moving behavior using one acceleration sensor and one air pressure sensor is discussed. Foot-to-head acceleration frequently varies during walking, and is used to classify the moving behavior into stepping action and rest. Walking patterns such as normal walking and jogging are estimated from variances of foot-to-head acceleration. Slight change of air pressure which results from vertical movement is used to detect the moving styles of going up/down the stairs or in an elevator. A combination of these features gives several kinds of moving patterns. The proposed method enables simple and reliable estimation of human moving pattern at the rate of 95% accuracy.
Recent advances in myocardial contrast echocardiography (1997)

In the past few years, significant advances have been made in the production of microbubbles that are more stable in the circulation. Our understanding of the interactions between microbubbles and ultrasound has also led to the development of new ultrasound imaging techniques that result in excellent myocardial opacification after an intravenous administration of microbubbles. This review focuses on advances made with these technologies in the setting of acute coronary syndromes and chronic coronary artery disease.
High‐order incremental sigma–delta for compressive sensing and its application to image sensors (2015)

ΣΔ ADCs show promising perspectives in the field of compressive sensing (CS). A major limitation related to the first‐order ΣΔ is its high oversampling ratio (OSR) that is required for a specific bit resolution. An extension to the high‐order incremental ΣΔ for the implementation of a dedicated image sensor is presented. By extending the concept of the ΣΔ CS ADC, optimal working points can be reached between the OSR and the compression ratio. Simulations of a particular fourth‐order ADC combined with the authors column‐based Bernoulli CS scheme show a severe relaxation on the ADC master clock.
Anti-Counterfeit, Advanced Microelectronics Packaging Solutions for Miniaturized Medical Devices (2013)

The medical industry is clearly and urgently in need of development of advanced packaging that can meet the growing demand for miniaturization, high-speed performance, and flexibility for handheld, portable, in vivo, and implantable devices. To accomplish this, new packaging structures need to be able to integrate more dies with greater function, higher I/O counts, smaller die pad pitches, and high reliability, while being pushed into smaller and smaller footprints. As a result, the microelectronics industry is moving toward alternative, innovative approaches as solutions for squeezing more function into smaller packages. This paper discusses the development of advanced packaging that can meet the growing demand for miniaturization, high-speed performance, and flexibility for miniaturized electronic devices. In particular, recent developments in high density interconnect (HDI) substrate technology are highlighted. System-in-Package (SiP), embedded passives, stacked packages, and flex substrates are utilized to achieve significant reduction in size, weight, and power (SWaP) consumption in electronic devices. The paper also describes a novel approach for the fabrication of silicone-coated flexible substrates to provide biocompatibility for implantable devices. In particular, we highlight recent developments on silicone coatings on high density, miniaturized polyimide-based flexible electronics. A variety of high density circuits ranging from 11 microns lines/space to 25 microns lines/spaces were processed on polyimide flex substrates and subsequently coated with biocompatible silicone coatings. The electrical performance of silicone coated batteries was characterized by voltage measurements. The final structure enhances the stretching capability. Fabrication of advanced medical substrates incorporating technologies for parts authentication (anticounterfeit measures) such as embedded signature circuits and use of nano or micro materials as signatures are discussed. In some instances, these measures do not add cost to package fabrication.
Unusually Large P.M.R. Coupling Constants in II-Allyl Palladium Complexes (1972)

Abstract In previously reported p.m.r. studies of II-allyl Palladium complexes it has been found that syn-syn couplings are much larger than syn-anti and anti-anti couplings1,2, these latter couplings being of the order of zero. In the course of studies in our laboratories on various II-allyl Palladium complexes we have found that in some cases syn-anti couplings of similar magnitude to syn-syn couplings, and that the line shape of the anti proton resonances indicate the presence of anti-anti unresolved couplings.
Determination of azimuthal anchoring energy in grating-aligned twisted nematic liquid-crystal layers (1997)

In this work sinusoidal diffraction gratings with a range of pitches and amplitudes are used to align nematic liquid-crystal layers in a twisted homogeneous configuration. The grating profiles are accurately characterized using optical surface plasmon polariton spectroscopy, which then allows a calculation of the anchoring energy as predicted by the simple Berreman expression. The experimental Rapini–Papoular anchoring energy is also obtained by a measurement of the director twist away from the alignment direction (easy axis) at room temperature. A linear relationship is found between the two anchoring energies, except when it falls below 4×10−7 J m−2. Noticeably, the correlation between the two theories is not unity, if room-temperature elastic constants are used in the calculation. This apparent inconsistency is explained if the effect of surface memory on the system is considered. Indeed, if elastic constants, corresponding to a higher temperature at which surface memory effects are absent, are used in the Berreman expression, good agreement between the predicted and experimentally measured energies is found.
Fast switching of conjugated polymer films (2006)

It is important to increase the switching speed of conjugated polymers between oxidized and reduced states for a wide range of devices, including capacitors, electrochromic displays, and actuators. In this paper, we compare the in-plane and the out-of- plane ion transport speed during electrochemical reduction of a conjugated polymer, polypyrrole doped with dodecylbenzenesulfonate. Results show that the in-plane ion transport is approximately 50 times faster than out-of-plane transport. The anisotropy is likely induced by the dodecylbenzenesulfonate, which has been shown previously to form layers parallel to the surface. An engineering method is presented to enhance the in-plane ion transport by etching pores into the polymer.
Myocardial adaptation to ischemia by oxidative stress induced by endotoxin (1995)

In this study, we examined the effects of oxidative stress adaptation on myocardial ischemic reperfusion injury. Oxidative stress was induced by injecting endotoxin (0.5 mg/kg) into the rat. After 24 h, rats were killed, hearts were isolated, and the effects of ischemia-reperfusion were studied using an isolated working heart preparation. The development of oxidative stress was examined by assessing malonaldehyde production in the heart. The antioxidant defense system was studied by estimating antioxidant enzyme activities and ascorbate- as well as thiol-dependent antioxidant reserve. The results of our study indicated that endotoxin induced oxidative stress within 1 h of treatment; the stress was reduced progressively and steadily up to 24 h. The antioxidant enzymes superoxide dismutase, catalase, glutathione (GSH) peroxidase, and GSH reductase were lowered up to 2 h and then increased. Both thiol- and ascorbate-dependent antioxidant reserve were enhanced, but the enhancement of the former was only transitory. After 24 h, endotoxin provided adequate protection to the heart from the ischemic-reperfusion injury, as evidenced by improved left ventricular function and aortic flow. Our results suggest that the induction of oxidative stress by endotoxin-induced adaptive modification of the antioxidant defense in the heart, thereby reducing ischemic-reperfusion injury.
A new image processing for precise image reproduction in high-resolution CT images (2009)

Poster: ECR 2009 / C-786 / A new image processing for precise image reproduction in high-resolution CT images by: S. Terakawa 1, K. Ichikawa2, T. Hara3, I. Fujimura4, Y. Miura1, Y. Hamada1, M. Inoue1; 1Osaka/JP, 2Kanazawa/JP, 3Nakatsugawa/JP, 4Izumi-sano/JP
Using Genetic Algorithms to Rehabilitate Distribution Systems (2001)

Many US water supply infrastructure systems are nearly 100 years old. Where as some are working nearly as efficiently as when they were first installed, others are showing their age with clogging, leaks, breaks, and service disruptions. To pinpoint the best solutions for each particular project, past practices often involved a tedious trial‐and‐evaluation procedure that seldom led to the most effective or most economical solutions for upgrading pipe networks. Because these upgrades and modifications are usually very expensive, it is imperative that sound analytical procedures are used to select economical design and rehabilitation alternatives. The fast messy genetic algorithm (fmGA), based on outcomes seen in nature, automatically determines low‐cost design rehabilitation and expansion alternatives that best meet prescribed system performance criteria. This methodology helps water utilities streamline their network rehabilitation and capital expenditure requirements and determine facility sizing and timing for system enhancements and expansions. This optimization procedure is a variation of the GA, a popular intelligent search procedure based on the mechanics of natural selection and evolution. The hydraulic simulation is performed using an extended version of the EPANET water distribution network solver. It selects least‐cost improvement alternatives that satisfy designated constraints on the network hydraulic performance for any given range of demand loading and operating conditions. This research compared outcomes using the fmGA method with three water distribution system examples taken from the literature. The fmGA found cost‐effective solutions much more quickly than the previously used analytical methods.
Wireless-Powered Cooperative Multi-Relay Systems With Relay Selection (2017)

This work was supported in part by the China MOST Program of International S&T Cooperation under Grant 2016YFE0133000 and Grant 2016YFE0119000, in part by the National Natural Science Foundation of China (NSFC) under Grant 61461136004, in part by NSFC Major International Joint Research Project under Grant 61210002, in part by the Fundamental Research Funds for the Central Universities under Grant 2015XJGH011, in part by EU Horizon 2020 Program EXCITING project under Grant 723227, in part by EU FP7 CROWN project under Grant PIRSES-GA-2013-610524, and in part by the China International Joint Research Center of Green Communications and Networking under Grant 2015B01008.
Genetic analysis of candidate loci in non‐syndromic cleft lip families from Antioquia‐Colombia and Ohio (2004)

Non-syndromic cleft lip with or without cleft palate (CL/P) is a genetically complex birth defect, with a prevalence from 1/500 to 1/1,000 live births. Evidence from linkage and linkage disequilibrium studies is contradictory suggesting that heterogeneity between study populations may exist. A recent report of a genome widescan in 92 sib pairs from the United Kingdom revealed suggestive linkage to 10 loci [Prescott et al., 2000]. The purpose of this study is to replicate those results and evaluate additional candidate genes in 49 Colombian and 13 Ohio families. Genotypes were obtained for STRPs at 1p36, 2p13 (TGFA), 4p16 (MSX1), 6p23-25, 6q25-27, 8q23-24, 11p12-q13, 12q13, 14q24 (TGFB3), 16q22-24, 17q12-21 (RARA), and Xcen-q21. Linkage was performed using parametric (dominant and recessive models) and non-parametric (GenehunterNPL and SimIBD) analyses. In addition, heterogeneity was analyzed using GenehunterHLOD, and association determined by the TDT. The Colombian families showed significant SimIBD results for 11p12-q13 (P = 0.034), 12q13 (P = 0.015), 16q22-24 (0.01), and 17q12-21 (0.009), while the Ohio families showed significant SimIBD results for 1p36 (P = 0.02), TGFA (P = 0.005), 6p23 (P = 0.004), 11p12-q13 (P = 0.048) and significant NPL results for TGFA (NPL = 3.01, P = 0.009), 4p16 (MNPL = 2.07, P = 0.03) and 12q13 (SNPL = 3.55, P = 0.007). Significant association results were obtained only for the Colombian families in the regions 1p36 (P = 0.046), 6p23-25 (P = 0.020), and 12q13 (P = 0.046). In addition several families yielded LOD scores ranging from 1.09 to 1.73, for loci at 4p16, 6p23-25, 16q22-24, and 17q13. These results confirm previous reports for these loci. However, the differences between the two populations suggest that population specific locus heterogeneity exists. This article contains supplementary material, which may be viewed at the American Journal of Medical Genetics website at http://www.interscience.wiley.com/jpages/0148-7299/suppmat/index.html.
Chemoselective Nucleophilic Attack on N‐Acyl Derivatives of (S)‐Ethyl 4,4‐Dimethyl Pyroglutamate (DMPG). (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
ADSoluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer’s disease progression (2019)

Abstract Soluble aggregates of amyloid-β (Aβ) have been associated with neuronal and synaptic loss in Alzheimer’s disease (AD). However, despite significant recent progress, the mechanisms by which these aggregated species contribute to disease progression are not fully determined. As the analysis of human cerebrospinal fluid (CSF) provides an accessible window into the molecular changes associated with the disease progression, we studied the soluble Aβ aggregates present in CSF samples from individuals with AD, mild cognitive impairment (MCI) and healthy controls. We found that these aggregates vary structurally and in their mechanisms of toxicity. More small aggregates of Aβ that can cause membrane permeabilization already found in MCI; in established AD, the aggregates were larger and more prone to elicit a pro-inflammatory response in glial cells. These results suggest that different neurotoxic mechanisms are prevalent at different stages of AD.
New Screen-printed Thermal Microactuator (2007)

A new process derived from the screen-printing technology and based on thick-film sacrificial layers has been developed for the fabrication of electrothermal microactuators. Studies of physico-chemical and functional properties of the actuator as well as comparison with analytical simulations confirm the validity and efficiency of the process. Compared to silicon, the metallic electrothermal actuator offers the possibility of producing small deflections with large driving forces. Preliminary experiments and simulations show that the buckling effect would be suitable for applications with such thick-film metallic actuators.
Low delay data gathering method for rice cultivation management system: IoT specialized outdoor communication procedure (2018)

In order to reduce the burden of agricultural work, rice cultivation management systems using sensor nodes, aka field servers, that monitor the environment are studied. It is difficult to install large power generation devices, such as solar panels, in rice fields as they obstruct farm work. In addition, it is also difficult to install the wiring for power supplies. For these reasons, each sensor node must operate on independent power with batteries or other power sources. Furthermore, given that they continue to operate during the farming season, low power consumption is required. It is difficult to use a communication network that requires a line use fee such as a 3G line from the viewpoint of cost. Therefore, in this paper, we report on a transmission method using LoRa, which is a communication standard for IoT, which does not require a line usage fee. In particular, we propose a data collection method that makes it possible to collect the data of all sensor nodes in a short amount of time. This method is effective for low power consumption. The comparison results with a conventional method using a simulation demonstrate that the proposed method can collect all of the data in the shortest amount of time. Moreover, it was confirmed that the power consumption is also lower than the conventional method. Furthermore, it was confirmed that the rate of increase in time necessary for the parent node to collect data, due to the increase in the number of sensor nodes, is lower than that of the other methods. We believe that the proposed method is useful and can efficiently transmit the situation of a rice field at a low cost.
Expression Vectors for Methanococcus maripaludis: Overexpression of Acetohydroxyacid Synthase and β-Galactosidase (1999)

A series of integrative and shuttle expression vectors was developed for use in Methanococcus maripaludis. The integrative expression vectors contained the Methanococcus voltae histone promoter and multiple cloning sites designed for efficient cloning of DNA. Upon transformation, they can be used to overexpress specific homologous genes in M. maripaludis. When tested with ilvBN, which encodes the large and small subunits of acetohydroxyacid synthase, transformants possessed specific activity 13-fold higher than that of the wild type. An expression shuttle vector, based on the cryptic plasmid pURB500 and the components of the integrative vector, was also developed for the expression of heterologous genes in M. maripaludis. The beta-galactosidase gene from Escherichia coli was expressed to approximately 1% of the total cellular protein using this vector. During this work, the genes for the acetohydroxyacid synthase (ilvBN) and phosphoenolpyruvate synthase (ppsA) were sequenced from a M. maripaludis genomic library.
Third-order approximation of the displacement of a caustic point due to a generalized bending (1980)

The motion of a caustic point for an axial object point is studied while the lens is perturbed by a generalized bending. It is shown that, to third order, the direction of motion is constant. The magnitude of the motion is proportional to the change in the third-order aberration coefficient. An application to the optical design process is indicated.
Diffraction by macromolecular fluids (1992)

X-Ray diffraction data on n-alkane fluids ranging from n-butane to polyethylene are analysed to yield the relative contributions from intra- and inter-molecular scattering. The intramolecular contributions are calculated from an exact rotational-isomeric-state model at short length scales, and approximated by a semiflexible chain model on global scales. With increasing chain length, the intermolecular pair distribution functions show a general decrease in short-range structure along with the predicted self-screening, or de Gennes ‘correlation hole’, whereby sites on different chains are partially excluded from close approach to sites on a given chain.
Parametric and Topological Control in Shape Optimization (2006)

We propose a novel approach to shape optimization that combines and retains the advantages of the earlier optimization techniques. The shapes in the design space are represented implicitly as level sets of a higher-dimensional function that is constructed using B-splines (to allow free-form deformations), and parameterized primitives combined with R-functions (to support desired parametric changes). Our approach to shape design and optimization offers great flexibility because it provides explicit parametric control of geometry and topology within a large space of freeform shapes. The resulting method is also general in that it subsumes most other types of shape optimization as special cases. We describe an implementation of the proposed technique with attractive numerical properties. The effectiveness of the method is demonstrated by several numerical examples.