gebhart/patrepeval huggingface dataset:
[Nanotechnology applications in pharmacology]. (2008)

The applications of nanotechnology to pharmacology are reviewed. The potential applications of biochips, nanosensors, bioreactors, neural stem cells, immune nanoparticles, biodegradable polymers, and convection-enhanced drug delivery in the diagnostics and treatment of diseases are discussed. Specific attention is given to developments in chemotherapeutic means, including advanced drug delivery systems and targeted nanotherapy, which will form the basis of the future nanomedicine. Numerous novel medicinal forms are discussed, including polymeric nanoparticles, nanotubes, micelles, liposomes, dendrimers, fullerenes, and hydrogels. In particular, highly stable glycosphyngolipid nanotubes and nanoliposomes are proposed as drug delivery systems. For this purpose, the model of stimulation of skin vasomotor reactions by nitroglycerin application is developed. The effect of nitroglycerin is shown to increase 1.5 times when used in the form of a dispersion with nanotubes as carriers and almost 2.5 times in the case of a dispersion with nanoliposomes as carriers. Nanotechnologically manufactured biologically active substances Apiton-25 (containing apis products) and Microhydrin (containing SiO 2 nanoparticles, silicon hydrogen bonds Si-H, and free negative charges for free radical neutralization) have been studied. The results indicate that both Apiton-25 and Microhydrin upon peroral administration enhance the cyclic trial performance during prolonged submaximal exercise in endurance-trained cyclists.
Heterozygous ATP2A2 missense variant identified in a Shih Tzu with Darier disease (2023)

Darier disease is caused by heterozygous loss of function variants in the ATP2A2 gene encoding the endoplasmic/sarcoplasmic reticulum Ca<sup>2+</sup> pump ATP2A2. Defective intracellular calcium signaling in the epidermis results in a loss of desmosomal adhesion and the development of characteristic skin lesions. In this study, we investigated a Shih Tzu that developed erythematous papules on the ventrum and, over time, the dorsal neck and a nodule in the right ear canal with secondary ear infection. Histopathologic examination demonstrated discrete foci of acantholysis affecting suprabasal layers of the epidermis. Whole genome sequencing of the affected dog identified a heterozygous missense variant, p.N809H, affecting an evolutionarily conserved amino acid residue of the ATP2A2 protein. The highly characteristic clinical and histopathologic findings together with a plausible variant in the only known functional candidate gene establish the diagnosis of canine Darier disease in the studied dog and highlight the potential of genetic analyses as complementary diagnostic approach in veterinary medicine.
A RFID Field Operation System Design for Agricultural Traceability (2010)

In this paper, we were introduced the concept and traceability development of the organic agriculture, and proposed the RFID-embedded mobile farming system for agriculture. The system is developed to reduce the time of paper record and typing errors, and to improve trust of organic food traceability and approach working management of agribusiness.
Paternal directional mating in two Amerindian subpopulations located at different altitudes in northwestern Argentina. (1998)

We used mitochondrial DNA (mtDNA) and Y-chromosome DNA polymorphisms to analyze the ethnic origin of maternal and paternal lineages in two Amerindian subpopulations from northwestern Argentina. One of the subpopulations was from San Salvador de Jujuy, located 1200 m above sea level. The second subpopulation inhabits the Quebrada de Humahuaca area at altitudes ranging from 2500 to 3500 m. Both subpopulations have the same ethnic background. All mtDNA haplotypes were identified as Amerindian with a frequency of 64.6% of the B form (9-bp deletion in mtDNA region V). Because all Central Andean Amerindian populations studied so far exhibit high frequencies of the B haplotype, we propose that they probably are derived from a common ancestral population that inhabited the Central Andes 6000-8000 years B.P. The presence of paternal directional mating (asymmetric contribution of one parental lineage to interethnic gene mixtures) was demonstrated by the finding of an average introgression of 40.5% Spanish Y chromosomes into our Amerindian sample. This introgression was more evident at low altitude than at high altitude, with frequencies of 64.3% in San Salvador de Jujuy (low altitude) and 27.6% in Quebrada de Humahuaca (high altitude) (p < 0.05). The San Salvador de Jujuy subpopulation also showed a significantly higher Y-chromosome gene variability than the Quebrada de Humahuaca subpopulation. These findings are in good agreement with historical reports indicating that the colonization of South America was undertaken by men who usually practiced polygamous unions with Amerindian women and that San Salvador de Jujuy was the main northwestern Argentinian region of European to Amerindian gene admixture. We found 16.7% of cases with Spanish Y chromosomes and Amerindian family names, and the same percentage with Amerindian Y chromosomes and Hispanic names. The former group probably is the result of unions between Hispanic men, who transmitted the Y chromosome, and Amerindian women, who transmitted the family name to the progeny. The latter group likely illustrates the practice of changing names from Amerindian to Hispanic during the baptism of native Americans in colonial times.
Spatiotemporal Patterns and Threshold of Chlorophyll-a in Lake Taihu Based on Microcystins (2021)

Abstract Chlorophyll-a (Chl- a ) is considered an indicator of phytoplankton biomass dynamically reflecting the growth of algae. Therefore, determination of Chl- a threshold is of vital importance to the health of aquatic ecosystems and drinking water security. This research is aimed to investigate the spatial and temporal distributions of Chl- a and microcystin (MC) concentrations using Geographic Information System (GIS) and identify the Chl- a threshold in Lake Taihu based on available guideline values of MCs. Nearly the same characteristics of spatiotemporal variation of Chl- a and MCs were observed in Lake Taihu. Overall, the lakewide distributions of Chl- a and MCs were highly variable over time and space. The Chl- a concentration in the winter and spring was relatively low, and gradually increasing in summer and autumn, with the maximum concentration observed in August. But the maximum MCs concentration appeared in October, two months lagging behind the Chl- a . The highest annual average Chl- a and MCs concentrations were observed in Zhushan Bay, Meiliang Bay, Gonghu Bay in northwest of Lake Taihu, following by West Zone and Center Zone. Dongtaihu Bay, East Zone and South Zone always present good water quality. Referring to the guideline value of MCs, the Chl- a threshold was determined as 10-15 mg·m -3 based on the linear regression correlation between Chl- a and MCs. The establishment of Chl- a threshold is useful for eutrophication control, water quality management and drinking water utilities in developing water safety plans.
Separation of Hydrogen from Carbon Dioxide through Porous Ceramics (2016)

The gas permeability of α-alumina, yttria-stabilized zirconia (YSZ), and silicon carbide porous ceramics toward H₂, CO₂, and H₂-CO₂ mixtures were investigated at room temperature. The permeation of H₂ and CO₂ single gases occurred above a critical pressure gradient, which was smaller for H₂ gas than for CO₂ gas. When the Knudsen number (λ/<i>r</i> ratio, λ: molecular mean free path, <i>r</i>: pore radius) of a single gas was larger than unity, Knudsen flow became the dominant gas transportation process. The H₂ fraction for the mixed gas of (20%-80%) H₂-(80%-20%) CO₂ through porous Al₂O₃, YSZ, and SiC approached unity with decreasing pressure gradient. The high fraction of H₂ gas was closely related to the difference in the critical pressure gradient values of H₂ and CO₂ single gas, the inlet mixed gas composition, and the gas flow mechanism of the mixed gas. Moisture in the atmosphere adsorbed easily on the porous ceramics and affected the critical pressure gradient, leading to the increased selectivity of H₂ gas.
Optimising Adoptive T Cell Therapy Following Allogeneic Hematopoietic Stem Cell Transplantation (2010)

Allogeneic hematopoietic stem cell transplantation (HSCT) is carried out to correct genetic disorders of the hematopoietic system, as well as to treat hematopoietic malignancies. Adoptive Tcell therapy has great potential as an adjunct to this treatment modality, and clinical trials have already demonstrated the feasibility and efficacy of this approach. It offers two therapeutic effects in this setting:(1) Augmentation of anti-tumor responses, such as in the setting of relapsed disease; (2) Prevention and treatment of transplant-related infections.Underlying the therapeutic efficacy of adoptive T cell therapy is the demonstration of a graft-vs-leukemia/lymphoma (GvL) effect
Selectively Patterning Polymer Opal Films via Microimprint Lithography (2014)

Large-scale structural color flexible coatings have been hard to create, and patterning color on them is key to many applications, including large-area strain sensors, wall-size displays, security devices, and smart fabrics. To achieve controlled tuning, a micro-imprinting technique is applied here to pattern both the surface morphology and the structural color of the polymer opal films (POFs). These POFs are made of 3D ordered arrays of hard spherical particles embedded inside soft shells. The soft outer shells cause the POFs to deform upon imprinting with a pre-patterned stamp, driving a flow of the soft polymer and a rearrangement of the hard spheres within the films. As a result, a patterned surface morphology is generated within the POFs and the structural colors are selectively modified within different regions. These changes are dependent on the pressure, temperature, and duration of imprinting, as well as the feature sizes in the stamps. Moreover, the pattern geometry and structural colors can then be further tuned by stretching. Micropattern color generation upon imprinting depends on control of colloidal transport in a polymer matrix under shear flow and brings many potential properties including stretchability and tunability, as well as being of fundamental interest.
On the role of p53 in the cellular response to aneuploidy (2021)

Most solid tumors are aneuploid, and p53 has been implicated as the guardian of the euploid genome. Previous experiments using human cell lines showed that aneuploidy induction leads to p53 accumulation and p21-mediated G1 cell cycle arrest. We find that adherent 2-dimensional (2D) cultures of human immortalized or cancer cell lines activate p53 upon aneuploidy induction, whereas suspension cultures of a human lymphoid cell line undergo a p53-independent cell cycle arrest. Surprisingly, 3D human and mouse organotypic cultures from neural, intestinal, or mammary epithelial tissues do not activate p53 or arrest in G1 following aneuploidy induction. p53-deficient colon organoids have increased aneuploidy and frequent lagging chromosomes and multipolar spindles during mitosis. These data suggest that p53 may not act as a universal surveillance factor restricting the proliferation of aneuploid cells but instead helps directly or indirectly ensure faithful chromosome transmission likely by preventing polyploidization and influencing spindle mechanics.
Applications of solubility parameters and other cohesion parameters in polymer science and technology (1985)

Abstract
Preliminary clinical experience with dezocine, a new potent analgesic (1980)

The analgesic effect of a single intravenous dose of dezocine at various dosage levels was studied in 41 patients suffering from acute renal colic. Twenty milligrams was found to be a very effective dose. Out of 25 injections an excellent response was recorded on 21 occasions, with a mean duration of effect of 3.5 hours. In a further 3 patients, pain relief was considered as fair and of shorter duration. Pronounced dizziness was a nearly constant side-effect of the drug. There was no overall effect on blood pressure or heart rate.
System and lead extractions (2018)

This chapter covers system and lead extractions, including the principles and indications for decisions to explant or extract leads, methods of patient preparation, and techniques. The specific tools for lead extraction, such as a locking stylet, needle’s eye snare, and extraction sheaths are explained. The EDS and laser systems for described. The superior venous approach and femoral venous extraction are explained in a step-by-step method, including practical tips. Factors that increase the risk of complications are defined, along with the major and minor problems that can occur in a lead extraction.
Improving Nonspecific Binding and Solubility: Bicycloalkyl Groups and Cubanes as para‐Phenyl Bioisosteres (2017)

Bicycloalkyl groups have been previously described as phenyl group bioisosteres. This article describes the synthesis of new building blocks allowing their introduction into complex molecules, and explores their use as a means to modify the physicochemical properties of drug candidates and improve the quality of imaging agents. In particular, the replacement of an aromatic ring with a bicyclo[1.1.1]pentane-1,3-diyl (BCP) group improves aqueous solubility by at least 50-fold, and markedly decreases nonspecific binding (NSB) as measured by CHI(IAM), the chromatographic hydrophobicity index on immobilized artificial membranes. Structural variations with the bicyclo[2.2.2]octane-1,4-diyl group led to more lipophilic molecules and did not show the same benefits regarding NSB or solubility, whereas substitutions with cubane-1,4-diyl showed improvements for both parameters. These results confirm the potential advantages of both BCP and cubane motifs as bioisosteric replacements for optimizing para-phenyl-substituted molecules.
Organocatalysis for depolymerisation (2018)

Chemical recycling of plastics offers a green method to deal with plastic waste. In this review, we highlight the recent advances made by applying organocatalysts to chemically degrade polymers as a promising tool to reach a circular plastic economy.
Planar‐Chiral [7]Orthocyclophanes (2012)

Just plain chiral: The [7]orthocyclophanes 1, having an E-olefinic ansa chain, exhibit planar chirality at ambient temperature and their stereochemical stabilities are highly dependent upon the embedded X group in the ansa chain. Inter- and intramolecular transformations of 1 (where X=NTs) provide a variety of nitrogen-containing chiral molecules in a stereospecific manner. Ts=4-toluenesulfonyl. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
<title>Correction of large dynamic aberrations by real-time holography using electro-optical devices and nonlinear optical media</title> (1998)

Real-time holography compensates for severely aberrated primary mirrors in large aperture telescope systems. A prototype optically addressed liquid-crystal spatial light modulator device developed for this application is demonstrated with short response times, approximately 600 microsecond(s), and high diffraction efficiencies approaching 40%.
A scalable sub-1.2mW 300MHz-to-1.5GHz host-clock PLL for system-on-chip in 32nm CMOS (2011)

System-on-chips (SoCs) are being widely adopted in mobile applications, and are driven by the need for longer battery life, their power budget continues to decrease. In addition, the phase-locked loop (PLL) for the SoC host clock has to be a very low power circuit to support the always-on always-connected (AOAC) feature for SoCs integrated into hand-held devices. The proposed PLL, imple mented in a high-k metal-gate 32nm logic CMOS technology, provides process scalability to the next process technology node, uncompromised system response, and loop stability under process variation and minimum power envel op constraints. As the jitter requirements for the host clocking PLL are not strin gent, the proposed architecture emphasizes the power efficiency over the jitter performance.
Proximity Sensing for Contact Tracing. (2020)

The TC4TL (Too Close For Too Long) challenge is aimed towards designing an effective proximity sensing algorithm that can accurately provide exposure notifications. In this paper, we describe our approach to model sensor and other device-level data to estimate the distance between two phones. We also present our research and data analysis on the TC4TL challenge and discuss various limitations associated with the task, and the dataset used for this purpose.
Heat and Ozone Resistance of Bacillus Spores Isolated from Laboratory Animals (1990)

Heat resistance of free-spores of 78 Bacillus strains isolated from laboratory animals was examined. Spores of 41 out of 78 strains survived for 320 minutes at 70 degrees C, 27 for 160 min, at 100 degrees C, only one for 20 min. at 110 degrees C by autoclaving, and none for 5 min. at 120 degrees C. D-values at 100 degrees C of 9 strains determined were between 5.03 and 30.06 min. Spores of 9 strains from stock cultures were exposed to ozone gas at various conditions. Ozone resistance of spores was closely dependent upon relative humidity. D-values of the spores tested by treatment with 200 ppm ozone at 60% RH were over 200 min., especially over 1,000 min. in 4 strains, indicating that exposure to ozone at a moderate humidity for 6 hours could not sterilize Bacillus spores. At 90% RH, however, treatment with 200 ppm ozone for 6 hr. might be effective for a routine sterilization in laboratory animal facilities.
Phase II Study of Everolimus in Metastatic Malignant Melanoma (NCCTG-N0377, Alliance) (2018)

Everolimus does not have sufficient single-agent activity in MM; however, we have identified evidence of biological activity to provide a potential rationale for future combination studies.
Flow sorting of nuclear fragments in the analysis of chromatin organization and differentiation (1981)

Conference Abstract| April 01 1981 Flow sorting of nuclear fragments in the analysis of chromatin organization and differentiation Lars Bolund Lars Bolund 1Institute of Human Genetics University of Aarhus, DK-8000 Aarhus C, Denmark Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1981) 9 (2): 124P. https://doi.org/10.1042/bst009124pa Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation Lars Bolund; Flow sorting of nuclear fragments in the analysis of chromatin organization and differentiation. Biochem Soc Trans 1 April 1981; 9 (2): 124P. doi: https://doi.org/10.1042/bst009124pa Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1981 Biochemical Society1981 Article PDF first page preview Close Modal You do not currently have access to this content.
The QoGS Method Application for Selection of Computing Resources in Intercloud (2013)

In this paper the selection of the right Cloud in Intercloud of computing services for fulfilment of the user task is analyzed. The main problem approached is how to select the right Cloud in Intercloud for the user task when there are no available or relevant resources in the private and public Cloud. In this case the Cloud, which gives the calculation results to the user in the shortest time including waiting time in queue, should be selected. For selection of the right Cloud the QoGS method has been chosen. The principle schema of QoGS method application in Intercloud has been presented. However, QoGS method works properly if the right set of weighted coefficients (SoWC) is selected. Existing methods are not suitable for selection of weighted coefficients because they require sending a lot of test tasks to Intercloud. Therefore, a new algorithm for selection of the best SoWC is presented. Results of the experiment show that it allows minimizing the workload of Intercloud by test tasks significantly. DOI: http://dx.doi.org/10.5755/j01.eee.19.7.2080
PP.32.24 (2015)

Objective: We investigated left atrial (LA) function in relation to hypertension using two-dimensional speckle tracking echocardiography (STE) in subjects with preserved left ventricular (LV) ejection fraction, while accounting for LA enlargement and LV mass and diastolic function. Design and method: We performed standard two-dimensional and Doppler echocardiography and LA volumetric measurements and STE strain imaging in hypertensive patients (systolic/diastolic blood pressure > = 140/90 mmHg, or use of antihypertensive drugs, n = 124) and age- and sex-matched normotensive subjects (n = 124). We measured the peak LA velocity, strain and strain rate during systole and early and late diastole, respectively. We investigated the associations of interests in the presence or absence of LA enlargement (LA volume index > = 28 ml/m2). Results: Hypertensive and normotensive subjects had similar LV ejection fraction and LA diameter (P > = 0.22). However, hypertensive compared with normotensive subjects had enlarged LV and impaired diastolic function, and had increased LA volumetric measurements and decreased LA emptying fractions (P < 0.0001). Hypertensive patients also had impaired LA function, as measured by STE velocity, strain, and strain rate in general and in the absence of LA enlargement (P < 0.0001). The differences in LA STE strain rate during LV systole and LA contraction between hypertension and normotension in the absence of LA enlargement remained statistically significant (P < 0.001), after adjustment for age, sex, and LV mass index and E/E’. Conclusions: Hypertension is associated with impaired LA function, as assessed by STE strain imaging technique, even before LA enlargement develops and after LV remodeling is accounted for.
History of Tumescent Anesthesia, Part I: From American Surgical Textbooks of the 1920s and 1930s (1998)

The current technique of "tumescent anesthesia," popularized by Dr. Jeffrey A. Klein, has evolved from the developments of local anesthetic agents and various infusion devices over the last 110 years. "Tumescent anesthesia" is really a variation of a much older technique known as "massive infiltration" or "hard infiltration." By 1915 "massive infiltration analgesia with weak analgesic solutions" was a well-developed and widely used form of analgesia. Various pressurized or motorized devices for the propulsion of the solutions, flexible needles, multiple formulas, and many applications of the technique were described and illustrated in several standard American surgical textbooks of the 1920s and 1930s. The goal was to render a large field anesthetic and relatively bloodless by use of only regionally injected solutions. In our current era, Dr. Ed Hamacher et al. and Dr. Klein deserve credit for reintroducing this old technique and for establishing new parameters for lidocaine toxicity. It is important for us to remember that the current technique of "tumescent anesthesia" really evolved over the last 110 years as the synthesis of the ideas of many individuals throughout the world.