gebhart/patrepeval huggingface dataset:
In Vitro Potentiation of Human Natural Killer Cell Activity by a Streptococcal Preparation, OK-432: Interferon and Interleukin-2 Participation in the Stimulation With OK-432<xref ref-type="fn" rid="FN2">2</xref> (1982)

Inasmuch as human natural killer (NK) cell activity was markedly augmented by a streptococcal immunopotentiator, OK-432, both in vivo and in vitro, the mechanism in which OK-432 augmented human NK cell activity was analyzed. Culture supernatants of nonadherent lymphocytes stimulated with OK-432 significantly augmented NK cell activity. Significant activity of both interferon (IFN) (both alpha- and gamma-types) and interleukin-2 (IL-2) was detected in the culture supernatants from nonadherent lymphocytes. Concomitant treatment of supernatants with anti-IFN-alpha antiserum and pH-2 glycine-HCI buffer or the absorption of supernatants with an IL-2-dependent cell line completely abrogated the NK-augmenting activity, whereas the treatment with either one of these resulted in only partial elimination of the activity. These results indicate that OK-432 stimulates human nonadherent lymphocytes to produce IFN and IL-2 and that both factors are primarily responsible for the NK augmentation by OK-432.
Bounds on the time to reach agreement in the presence of timing uncertainty (1994)

Upper and lower bounds are proved for the time complexity of the problem of reaching agreement m a distributed network m the presence of process fwlures and inexact information about time. It is assumed that the amount of (real) time between any two consecutwe steps of any ncmfatrhy process is at least c1 and at most C2; thus, C = cz/cl is a measure of the timing uncertainty.
Action of Grignard Reagents on Heterocyclic Compounds. I. Action of Grignard Reagents on Unsaturated Azlactones (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAction of Grignard Reagents on Heterocyclic Compounds. I. Action of Grignard Reagents on Unsaturated AzlactonesWILLIAM IBRAHIM AWAD and MOHAMED SHAWKEY HAFEZCite this: J. Org. Chem. 1960, 25, 7, 1180–1182Publication Date (Print):July 1, 1960Publication History Published online1 May 2002Published inissue 1 July 1960https://doi.org/10.1021/jo01077a026RIGHTS & PERMISSIONSArticle Views74Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (354 KB) Get e-Alertsclose Get e-Alerts
Primary structure of pyruvate dehydrogenase kinase establishes a new family of eukaryotic protein kinases. (1993)

We recently reported molecular cloning of the branched chain alpha-ketoacid dehydrogenase kinase, the first mitochondrial protein kinase to be cloned (Popov, K. M., Zhao, Y., Shimomura, Y., Kuntz, M. J., and Harris, R. A. (1992) J. Biol. Chem. 267, 13127-13130). From a search for proteins related to the branched chain alpha-ketoacid dehydrogenase kinase, a cDNA encoding the 434 amino acid residues corresponding to pyruvate dehydrogenase kinase has been cloned from a rat heart cDNA library. Evidence that the clone codes for pyruvate dehydrogenase kinase includes: (a) the deduced amino acid sequence is identical to the partial sequence of the kinase determined by direct sequencing; (b) expression of the cDNA in Escherichia coli resulted in synthesis of a protein that phosphorylated and inactivated the pyruvate dehydrogenase complex; (c) kinase activity of the recombinant protein is sensitive to inhibition by a specific inhibitor of pyruvate dehydrogenase kinase; and (d) antiserum raised against the recombinant protein recognized the protein subunit known to correspond to pyruvate dehydrogenase kinase in a highly purified preparation of the pyruvate dehydrogenase complex. Like the branched chain alpha-ketoacid dehydrogenase kinase, pyruvate dehydrogenase kinase lacks motifs usually associated with eukaryotic Ser/Thr-protein kinases. Considerable sequence similarity exists between these mitochondrial protein kinases and members of the prokaryotic histidine kinase family, a diverse set of sensing and response systems important in the regulation of bacterial processes. Thus, molecular cloning of these proteins establishes a new eukaryotic family of protein kinases that is related to a prokaryotic family of protein kinases.
Essential Function of Oncostatin M in Nociceptive Neurons of Dorsal Root Ganglia (2004)

Oncostatin M (OSM) is a member of the interleukin-6 family of cytokines, and we have reported previously that the murine OSM receptor beta subunit (OSMR) was expressed in some neurons in the adult trigeminal and dorsal root ganglia (DRGs) and in the perineonatal hypoglossal nucleus. In the present study, we investigated the development of OSMR-positive neurons of DRGs in OSM-deficient mice. In situ hybridization revealed that OSMR-positive neurons in DRGs began to appear at postnatal day 0 (P0) and reached the adult level at P14. In the DRGs of the OSM-deficient mice, vanilloid receptor 1 (VR1)- and P2X3-positive small-sized neurons were significantly decreased. In addition, OSMR-positive neurons decreased, resulting in the reduced number of VR1/P2X3/OSMR-triple positive neurons. OSM-deficient mice displayed significantly reduced noxious responses in models of acute thermal, mechanical, chemical, and visceral pain. Thus, OSM plays an essential role in the development of a subtype of nociceptive neurons in the DRGs.
Human gene mapping 11 : London Conference (1991) : Eleventh International Workshop on Human Gene Mapping (1991)

The map location of some 470 additional genes has been added since the 1990 update of this manual, bringing the total to about 2350 genes, representing roughly 5% of all functional human genes. For the first time, a fairly large number of physical and linkage maps are included in the report. Of considerable interest to many workers in the field is the report of the DNA Committee. This includes a listing of nearly 7000 polymorphic DNA segments, 1530 clones and mapped genes, many markers and DNA polymorphisms formatted for PCR. The catalogue of human gene names and their official symbols is updated, as are reports on gene linkage and gene order, human and mouse genes, homologies, general comparative gene mapping, chromosome rearrangements in neoplasia, chromosome and gene loss in human neoplasia, clinical disorders and chromosome deletion syndromes, the location of 114 fragile chromosome sites and data on 55 mitochondrial genes.
Phase continuity in sequential poly(n-butyl acrylate)/polystyrene interpenetrating polymer networks (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhase continuity in sequential poly(n-butyl acrylate)/polystyrene interpenetrating polymer networksJ. M. Widmaier and L. H. SperlingCite this: Macromolecules 1982, 15, 2, 625–631Publication Date (Print):March 1, 1982Publication History Published online1 May 2002Published inissue 1 March 1982https://pubs.acs.org/doi/10.1021/ma00230a081https://doi.org/10.1021/ma00230a081research-articleACS PublicationsRequest reuse permissionsArticle Views322Altmetric-Citations55LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Evaluation of Acute Adverse Events after Covid-19 Vaccination during Pregnancy (2022)

Evaluation of Acute Adverse Events after Covid-19Vaccination during Pregnancy 1 to 7 days after vaccination Fever Malaise
Time-Effective Component Selection Automation in Electric Vehicles using Openly-Available Data (2022)

Transportation electrification is at the core of the possible solutions to many challenges the world is currently facing. Efficient vehicle electrification has the potential to si-multaneously reduce greenhouse gasses emissions and decrease range anxiety. This paper proposes a methodology for component selection in each part of electric vehicle (EV) architecture, demon-strating the method with Power Electronics switches selection. A Design Automation (DA) simulation platform is introduced to facilitate EV model-based design. The approach includes considerations on the mechanical and electrical domain of the vehicle, accounting for the effect of the component in the whole system, and yielding the solution that optimizes range. Using the proposed method, the Pareto Front of a large pool of candidates is found, yielding a range-efficiency variation of approximately 16% within it.
Semantic Proto-Roles (2015)

We present the first large-scale, corpus based verification of Dowty’s seminal theory of proto-roles. Our results demonstrate both the need for and the feasibility of a property-based annotation scheme of semantic relationships, as opposed to the currently dominant notion of categorical roles.
Structural characterization of the α-N-acetylglucosaminidase, a key enzyme in the pathogenesis of Sanfilippo syndrome B (2019)

Mucopolysaccharidosis III B (MPS III-B) is a rare lysosomal storage disorder caused by deficiencies in Alpha-N-acetylglucosaminidase (NAGLU) for which there is currently no cure, and present treatment is largely supportive. Understanding the structure of NAGLU may allow for identification of novel therapeutic targets for MPS III-B. Here we describe the first crystal structure of human NAGLU, determined to a resolution of 2.3 Å. The crystal structure reveals a novel homotrimeric configuration, maintained primarily by hydrophobic and electrostatic interactions via domain II of three contiguous domains from the N- to C-terminus. The active site cleft is located between domains II and III. Catalytic glutamate residues, E316 and E446, are located at the top of the (α/β)<sub>8</sub> barrel structure in domain II. We utilized the three-dimensional structure of NAGLU to map several MPS III-B mutations, and hypothesize their functional consequences. Revealing atomic level structural information about this critical lysosomal enzyme paves the way for the design of novel therapeutics to target the underlying causes of MPS III-B.
Brillouin Optical Correlation Domain Analysis Addressing 440 000 Resolution Points (2016)

The distributed Brillouin analysis of an 8.8-km-long fiber with a spatial resolution of 2 cm is presented. All 440 000 potential resolution points are addressed in the measurement. A 7-cm-long hot-spot, located toward the output end of the pump wave, is properly identified in the experiment. The experimental error in the estimate of the local values of the Brillouin frequency shift is ±3.5 MHz. The analysis is based on the simultaneous generation and analysis of Brillouin interaction in more than 2000 correlation peaks, induced by periodic phase modulation of the pump and signal waves. The Brillouin amplifications at individual peaks are resolved using radar-like coding of pump wave magnitude by a 10000 bit-long aperiodic sequence, and postdetection compression at the receiver end. Extensive numerical simulations of the Brillouin interactions over kilometers of fiber with centimeter resolution are reported as well. The results are at the state of the art for high-resolution distributed Brillouin sensors.
Generation of short optical pulses in semiconductor lasers by combined DC and microwave current injection (1982)

We report picosecond pulse generation in low threshold buried optical guide lasers using combined direct and microwave current excitation. The pulse widths were obtained as a function of direct current for several levels of RF excitation using lasers 125 and 380 μm long. The pulses have a Gaussian shape with full widths at half maximum intensity ranging from 19 to 57 ps. The pulse widths were obtained from the second harmonic autocorrelation. The experimental results are in reasonable agreement with the theory of short pulse formation in sinusoidally modulated lasers. The pulse width decreases with increasing dc and microwave current, and decreasing laser length. The shortest pulses were obtained with a 125μm long laser using 0.25 W RF at 1 GHz and 35 mA de bias. Multiple pulses are emitted at high dc excitation levels. Using the above laser at the indicated current levels the emission consists of a burst of ∼10 pulses which are separated by 30 ps, and has an approximately exponentially decaying amplitude. Saturable absorption was introduced in the lasers by degradation and results in shortening the pulses. A comparison is made of the pulse widths obtained for sinusoidal microwave current modulation and for pulsed excitation where the excitation is obtained from a step recovery diode. Reduced pulse widths are obtained for short current pulse excitation.
Levels of Antioxidant Nutrients in Plasma and Low Density Lipoproteins: A Human Volunteer Supplementation Study (1995)

A human supplementation study was undertaken in order to investigate the correlation between the intake of individual daily dosages of vitamin E (300 mg), vitamin C (250 mg), or beta-carotene (15 mg) of eight week duration and their uptake in vivo in plasma and LDL. The effects of a combined supplement of vitamin E, vitamin C and beta-carotene (Redoxon protector-75 mg, 150 mg, 15 mg respectively) were also investigated. The results show that on supplementation with the individual antioxidants the increases in plasma alpha-tocopherol:cholesterol levels lie in the 1.5-2 fold range and the beta-carotene:cholesterol ratios give a mean 3.5 fold enhancement. The combined supplement containing the same level of beta-carotene as the single dosage achieved comparative levels of uptake in plasma. The level of plasma vitamin C appears to be maximal at about 100 microM regardless of the pre-supplementation level.
Cases with Refractory Ascites and a Delayed Response to Tolvaptan (2016)

The patient was a 67-year-old female with liver cirrhosis due to hepatitis C. She was administered furosemide at 20 mg/day and spironolactone at 25 mg/day, but the ascites did not improve. Despite the additional administration of tolvaptan at 3.75 mg/day, the response to ascites was still poor. While the dose of tolvaptan was thereafter increased to 7.5 mg/day on the 7th hospital day, the ascites still persisted. However, she continued to receive tolvaptan (7.5 mg/day) because the worsening of her subjective symptoms was mild and she wished to do so. The ascites was later found to have almost completely disappeared on computed tomography (CT) at 6 months.
Ytterbium Innoslab amplifiers - The high average power approach of ultrafast lasers (2012)

Ytterbium Innoslab amplifiers are designed for a good thermal management and low nonlinearity and enable ultrafast laser systems with high average power and almost diffraction limited beam quality. In the present contribution the extension of the Innoslab platform beyond the already realized 1 kW average power and 20 mJ pulse energy is discussed.
A Swirling-Flame Combustor for Lean Mixtures (1993)

Abstract A combustor for lean mixtures, employing heat recirculation and a new gas burner generating a swirling central flame, was developed and tested. Stability curves for burning lean mixtures of methane/air were determined. The leanest mixture which was burned before extinction, at a preheat temperature of 540° c and a flow rate of 1000 × 10−6 m3/s, contained 3.2% of methane. This figure is 60% of the normal flammability limit. The stability curves were determined at mean preheat temperatures of 35, 460 and 555° c, and for burners with some different geometrical parameters. Special attention has been paid to explore the effect of entrainment of uncontrolled amounts of air on the stability curves. It was found that the major characteristic property of the present apparatus is that for almost a constant preheat temperature, the concentration of fuel in the air, F/(F +A), is continuously decreasing by increasing the flow rate through the system; the latter being an important practical feature of the apparatus. On the other hand, the spouted and crater bed combustors, exhibited an optimal flow rate at which the above ratio attained a minimum value. By increasing the flow rate, the ratio F/(F +A) is increased approaching the lower limit of flammability. A qualitative model, based on diffusion-convection mass transfer of the fuel in the mixture to the reaction zone, is developed; it predicts some characteristic behaviours determined in the experiments. Additional informationNotes on contributorsA. TAMIR This work has been carried out while the author spent his sabbatical at Imperial College, London SW7 2BY, UK.
The Combination of a Retinoid, a Phenolic Agent and an Antioxidant Improves Tolerance while Retaining an Optimal Depigmenting Action in Reconstructed Epidermis (2013)

A combination of various chemicals acting via different mechanisms allows a decrease in the toxicity of each compound alone while retaining optimal skin-lightening properties.
How to Make Smartcards Resistant to Hackers' Lightsabers? (2010)

Cracking smartcards has always been a prized hobby, for the academic glory , for fun (ha, breaking the self-claimed unbreakable...) and for profit (ask the mafia). State-of-the-art techniques include laser blasts that inject various transient or permanent faults in a program execution, potentially making the smartcard do whatever the attacker wants. After a brief recap of the attack tools and their effects, we'll see how the programmer can protect his code with software techniques ranging from cookbook recipes to tool chain automation and how he can evaluate the robustness of his code by means of fault injection simulators.
ChemInform Abstract: A New α‐Iodination of Ketones Using Iodine‐Cerium(IV) Ammonium Nitrate. (1988)

Abstract α‐Iodination of ketones is performed using iodine in the presence of ceric ammonium nitrate.
Transgenesis procedures in Xenopus (2008)

Stable integration of foreign DNA into the frog genome has been the purpose of several studies aimed at generating transgenic animals or producing mutations of endogenous genes. Inserting DNA into a host genome can be achieved in a number of ways. In Xenopus, different strategies have been developed which exhibit specific molecular and technical features. Although several of these technologies were also applied in various model organizms, the attributes of each method have rarely been experimentally compared. Investigators are thus confronted with a difficult choice to discriminate which method would be best suited for their applications. To gain better understanding, a transgenesis workshop was organized by the X-omics consortium. Three procedures were assessed side-by-side, and the results obtained are used to illustrate this review. In addition, a number of reagents and tools have been set up for the purpose of gene expression and functional gene analyses. This not only improves the status of Xenopus as a powerful model for developmental studies, but also renders it suitable for sophisticated genetic approaches. Twenty years after the first reported transgenic Xenopus, we review the state of the art of transgenic research, focusing on the new perspectives in performing genetic studies in this species.
HAIC/HIWC Field Campaign - Specific Findings on PSD Microphysics in High IWC Regions from In Situ Measurements: Median Mass Diameters, Particle Size Distribution Characteristics and Ice Crystal Shapes (2015)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;Despite past research programs focusing on tropical convection, the explicit studies of high ice water content (IWC) regions in Mesoscale Convective Systems (MCS) are rare, although high IWC conditions are potentially encountered by commercial aircraft during multiple in-service engine powerloss and airdata probe events.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;To gather quantitative data in high IWC regions, a multi-year international HAIC/HIWC (High Altitude Ice Crystals / High Ice Water Content) field project has been designed including a first field campaign conducted out of Darwin (Australia) in 2014. The airborne instrumentation included a new reference bulk water content measurement probe and optical array probes (OAP) recording 2D images of encountered ice crystals.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;The study herein focuses on ice crystal size properties in high IWC regions, analyzing in detail the 2D image data from the particle measuring probes. Various geometrical parameters were extracted from the images in order to calculate particle size distributions (PSDs) and finally deduce median mass diameters with additional information on the ice density.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;The preliminary analysis of all HAIC/HIWC flights performed during this first flight campaign out of Darwin, demonstrates that various flights include high IWC regions mostly produced by high concentrations of small crystals while other flights with similar peak IWCs indicates that high IWC regions could be nevertheless composed primarily of larger particles. This interesting result indicates that high IWC can be produced and maintained in various environments, preferentially high concentrations of small crystals, however sometimes by smaller concentrations of larger sized crystal populations.&lt;/div&gt;&lt;/div&gt;
Aluminium Lithium (Al-Li) - Silicon Carbide (SiC) Composites by Powder Metallurgy (PM) Route (1994)

&lt;div class="htmlview paragraph"&gt;Aluminium-lithium (Al-Li) alloys have gained prominence in the aerospace industry in recent years as structural materials. This is due primarily to their mechanical properties, such as high specific strength and modulus, and low density.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;Development of Al-Li/ceramic composites is currently being investigated to enhance the higher service capabilities of this material. Processing of Al-Li/ceramic composites by the powder metallurgy (PM) route offers many advantages over ingot casting such as a well-dispersed reinforcement distribution and easy handling. However, the PM route suffers from agglomeration of the ceramic reinforcement when the particle size is below 2.5 μm.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;This paper reports the development of several methods of mixing submicron ceramic powders with Al-Li to obtain a uniform distribution of the reinforcement. Among the methods used were mixing in a fluidized bed, ball milling, spray drying and mixing the metal powder with a ceramic slurry. The results showed that the methods employed in ceramic processing such as the uses of deflocculants are important to the success of mixing the submicron ceramics to Al-Li.&lt;/div&gt;