gebhart/patrepeval huggingface dataset:
The transformation in vitro of peripheral lymphocytes of some laboratory animals. (1965)

The peripheral lymphocytes of monkeys, rabbits, guinea-pigs, hamsters, rats and mice were transformed in culture by phytohaemagglutinin and staphylococcal filtrate. The response was most marked with the peripheral lymphocytes of monkeys and rabbits and least marked with rat and mouse lymphocytes. The response occurred earlier with rabbit and guinea-pig than human lymphocytes. The short life span in vitro of rat and mouse lymphocytes adversely affected their response. The tritiated thymidine uptake of the stimulated lymphocytes of the various species was also limited by their rate of survival over the culture period. Attempts to obtain antigen-specific stimulation of peripheral rabbit and guinea-pig lymphocytes were unsuccessful.
Consequences of the Protonation of the 19-Electron Anion [Co(η5-C5H5)(1,5-C8H12)]− (2009)

The electrochemical and chemical reduction of CoCp(1,5-COD) (1, Cp = η5-C5H5; COD = cyclooctadiene) has been reinvestigated in THF. Whereas the initially formed monoanion 1− (E1/2 = −3.01 V vs Fc, Fc = FeCp20/+) has been well-characterized electrochemically and by ESR spectroscopy, the long-term electrolysis product had been previously assigned as the isomerized anion [CoCp(1,3-COD)]−. New magnetic resonance data show that the ultimate product is the 17-electron cyclooctenyl complex CoCp(η3-C8H13) (2, E1/2 = −2.17 V), formed by the reaction of 1− with adventitious proton donors. The η1:η3-bonded isomer of 1, CoCp(η1:η3-C8H12) (3), reduces (E1/2 = −2.97 V) to yield the same product 2 on the cyclic voltammetry (CV) time scale. Deliberate addition of the weak proton donor 2,4,6-trimethylphenol to solutions of 1 facilitates protonation and results in scan-rate- and concentration-dependent formation of 2 on the CV time scale as 1 is reduced in an ECE mechanism. Under these conditions, the reduced 2− anion undergoes further reaction with proton donors, which results in the formation of another electroactive product, 4, which is assigned the structure [CoCp(η3-C8H13)H] on the basis of NMR evidence and DFT calculations.
Toluene dioxygenase-mediated oxidation of aromatic substrates with remote chiral centers (2000)

Several aromatic substrates containing remote chiral centers were subjected to toluene and naphthalene dioxygenase expressed in blocked mutants and recombinant organisms yielding cis-diol metabolites with little or no kinetic resolution.
A major QTL controlling deep rooting on rice chromosome 4 (2013)

Drought is the most serious abiotic stress that hinders rice production under rainfed conditions. Breeding for deep rooting is a promising strategy to improve the root system architecture in shallow-rooting rice cultivars to avoid drought stress. We analysed the quantitative trait loci (QTLs) for the ratio of deep rooting (RDR) in three F₂ mapping populations derived from crosses between each of three shallow-rooting varieties ('ARC5955', 'Pinulupot1', and 'Tupa729') and a deep-rooting variety, 'Kinandang Patong'. In total, we detected five RDR QTLs on chromosomes 2, 4, and 6. In all three populations, QTLs on chromosome 4 were found to be located at similar positions; they explained from 32.0% to 56.6% of the total RDR phenotypic variance. This suggests that one or more key genetic factors controlling the root growth angle in rice is located in this region of chromosome 4.
Efficient and Interference-Resilient Wireless Connectivity for IoT Applications (2020)

With the coming of age of the Internet of Things (IoT), demand on ultra-low power (ULP) and low-cost radios will continue to boost tremendously. The Bluetooth-Low-energy (BLE) standard provides a low power solution to connect IoT nodes with mobile devices, however, the power of maintaining a connection with a reasonable latency remains the limiting factor in defining the lifetime of event-driven BLE devices. BLE radio power consumption is in the milliwatt range and can be duty cycled for average powers around 30μW, but at the expense of long latency. Furthermore, wireless transceivers traditionally perform local oscillator (LO) calibration using an external crystal oscillator (XTAL) that adds significant size and cost to a system. Removing the XTAL enables a true single-chip radio, but an alternate means for calibrating the LO is required. Innovations in both the system architecture and circuits implementation are essential for the design of truly ubiquitous receivers for IoT applications. This research presents two porotypes as back-channel BLE receivers, which have lower power consumption while still being robust in the presents of interference and able to receive back-channel message from BLE compliant transmitters. In addition, the first crystal-less transmitter with symmetric over-the-air clock recovery compliant with the BLE standard using a GFSK-Modulated BLE Packet is presented.
THE MECHANISM OF THE LEUCKART REACTION (1951)

ADVERTISEMENT RETURN TO ISSUEArticleNEXTTHE MECHANISM OF THE LEUCKART REACTIONC. B. POLLARD and DAVID C. YOUNGCite this: J. Org. Chem. 1951, 16, 5, 661–672Publication Date (Print):May 1, 1951Publication History Published online1 May 2002Published inissue 1 May 1951https://pubs.acs.org/doi/10.1021/jo01145a001https://doi.org/10.1021/jo01145a001research-articleACS PublicationsRequest reuse permissionsArticle Views3127Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Dispositifs Appliqués à la Photonique à base de Néodyme et de Silicium (2009)

poster
Nuclear Architecture Analysis of Prostate Cancer via Convolutional Neural Networks (2017)

In this paper, we present an approach of convolutional neural networks (CNNs) to identify prostate cancers. Prostate tissue specimen samples were obtained from the tissue microarrays and digitized. For each sample, epithelial nuclear seeds were identified and used to generate a nuclear seed map, i.e., only the location information of epithelial nuclei was utilized. From the nuclear seed maps, CNNs sought to learn the high-level feature representation of nuclear architecture and to detect cancers. Applying data augmentation technique, CNNs were trained on the training data set including 73 benign and 89 cancer samples and validated on the testing data set comprising 217 benign and 274 cancer samples. In detecting cancers, CNNs achieved an AUC of 0.974 (95% CI: 0.961-0.985). In comparison with the approaches of utilizing hand-crafted nuclear architecture features and the state of the art deep learning networks with standard machine learning methods, CNNs were significantly superior to them (p-value <; 5e-2). Moreover, stromal nuclei were incapable of improving the cancer detection performance. The experimental results suggest that our approach offers the ability to aid in improving prostate cancer pathology.
Effects of high-current pulses on polycrystalline silicon diode with n-type region heavily doped with both boron and phosphorus (1982)

A new phenomenon in polycrystalline silicon lateral diodes with very high doping concentrations is observed experimentally. The impurity concentrations of the experimental devices are greater than 1020 cm−3 in both n- and p-type regions, and the n-region is doped with both boron and phosphorus. When current pulses of 106 A/cm2 or larger are applied, abrupt transition of the current-voltage characteristics from those of a diode to those of a resistor is observed.
Laser Nanowarming: A platform technology for ultra-rapid rewarming of cryopreserved zebrafish embryos (2019)

University of Minnesota Ph.D. dissertation. June 2019. Major: Mechanical Engineering. Advisor: John Bischof. 1 computer file (PDF); xiii, 118 pages.
Correlations of inclusion-based rock-physics model inputs from Bayesian analysis (2022)

Abstract For any given rock-physics model, knowledge of correlations among its inputs helps to define geologically and physically meaningful and informed models for a given problem. These informed models can, in turn, reduce the uncertainty in forward and inverse problems. We use a Bayesian framework to identify such correlations among inputs of two rock-physics models. That framework makes use of velocity and porosity measurements on both dry and brine-saturated carbonate samples. Two inclusion-based rock-physics models, the self-consistent approximation and the differential effective medium model, are analyzed along with these data to identify the underlying correlations. To do so, the posterior distribution must be evaluated, which is based on a prior model and the calculated likelihood function. Exhaustive sampling of the posterior is convenient in this case because relatively few input parameters to consider. Results are multi-variate histograms that indicate maximum a posteriori values of the inputs. Correlations among the inputs become evident when the Bayesian analysis is repeated many times with different prior models. These correlated values provide the inputs to optimized maximum a posteriori models. The correlations identified for the two rock-physics models under study should be used in relevant applications. Finally, all rock-physics models, along with an appropriate data set, should be examined in a similar Bayesian framework.
Necrosis, and then stress induced necrosis-like cell death, but not apoptosis, should be the preferred cell death mode for chemotherapy: clearance of a few misconceptions (2014)

Cell death overarches carcinogenesis and is a center of cancer researches, especially therapy studies. There have been many nomenclatures on cell death, but only three cell death modes are genuine, i.e. apoptosis, necrosis and stress-induced cell death (SICD). Like apoptosis, SICD is programmed. Like necrosis, SICD is a pathological event and may trigger regeneration and scar formation. Therefore, SICD has subtypes of stress-induced apoptosis-like cell death (SIaLCD) and stress-induced necrosis-like cell death (SInLCD). Whereas apoptosis removes redundant but healthy cells, SICD removes useful but ill or damaged cells. Many studies on cell death involve cancer tissues that resemble parasites in the host patients, which is a complicated system as it involves immune clearance of the alien cancer cells by the host. Cancer resembles an evolutionarily lower-level organism having a weaker apoptosis potential and poorer DNA repair mechanisms. Hence, targeting apoptosis for cancer therapy, i.e. killing via SIaLCD, will be less efficacious and more toxic. On the other hand, necrosis of cancer cells releases cellular debris and components to stimulate immune function, thus counteracting therapy-caused immune suppression and making necrosis better than SIaLCD for chemo drug development.
Molecular dynamics modelling of water nanodroplet impingement on silicon dioxide and silicon nitride substrates (2014)

This paper reports the study of a droplet-based scalable micro/nanomanufacturing process using molecular dynamics (MD) modelling. The objective of the study is to understand the nanodroplet impingement and spreading mechanism on silicon dioxide (SiO 2 ) and silicon nitride (Si 3 N 4 ) substrates with different impingement velocities. The dependence of dynamic contact angle on the initial droplet velocity was investigated for hydrophilic and hydrophobic substrate interactions. Higher rebound effect and thereby slower wetting rates were observed for the SiO 2 -water system as compared to the Si 3 N 4 -water system for the same magnitudes of impingement velocities. The MD simulation results were validated using the molecular kinetic theory. Findings of this research are expected to establish the required process controls in droplet-based scalable nanomanufacturing for precision deposition of nanoscale features.
High‐performance liquid chromatography/nano‐electrospray ionization tandem mass spectrometry, two‐dimensional difference in‐gel electrophoresis and gene microarray identification of lymphatic metastasis‐associated biomarkers (2008)

The potential biomarkers for the lymphatic metastatic process of mouse hepatocarcinoma were investigated by using two-dimensional difference in-gel electrophoresis (2D DIGE), high-performance liquid chromatography/nano-electrospray ionization tandem mass spectrometry (HPLC/nESI-MS/MS) and GeneChip. 2D DIGE was performed to screen and quantify the differentially expressed proteins between two well-established mouse hepatocarcinoma cell lines, Hca-F with 75% and Hca-P with 25% metastasis rate of lymph node potentials. The protein spots in the gel were visualized by the highly sensitive Deep Purple (GE Healthcare) fluorescent stain. Protein identification was obtained for gel spots by HPLC/nESI-MS/MS analysis with high quality. GeneChip microarray was performed to identify genes differentially expressed at the mRNA level. Seventeen genes including the chloride intracellular channel l, caspase 3, fructose bisphosphatase 2, glutamate dehydrogenase 1, V-crk sarcoma virus CT10 oncogene homolog, N-myc downstream regulated gene1, villin2, gelsolin, enoyl coenzyme A hydratase 1, transketolase, vimentin, annexins A5 and A7, keratin complex2 basic gene7 and gene8, lactamase (bata 2) and Ero1-like protein were found abnormally regulated and expressed concordantly both at the protein and mRNA levels between the two cell lines. More than half of these genes were for the first time revealed to be involved directly in hepatocarcinoma due to the lymphatic metastasis. The interdisciplinary combination of HPLC/nESI-MS/MS with 2D DIGE and GeneChip techniques opens up the possibility for the biomarker discovery of disease with high confidence.
Research on Teaching Assessment System for Foreing Teachers in Coueges (2007)

Through the description of foreign teachers' teaching features,this article states the importance and necessity of establishing the teaching assessment system for foreign teachers in colleges.On the base of solving problems in foreign teachers' teaching and improving their teaching results,the author undertakes the research on teaching assessment system for foreign teachers and makes out initially the teaching assessment system for foreign teachers at East China Jiaotong University.
Phagocytosis in leprosy. 5. The effect of the infection with Mycobacterium lepraemurium on the level of diverse hydrolytic lysosomal enzymes of murine peritoneal macrophages. (1982)

The effect of the infection with M. lepraemurium on the activity of several lysosomal enzymes of mouse peritoneal cells was studied. The enzymes studies were acid- and alkaline-phosphatases, acid (cathepsin D-type) proteinase, beta-glucuronidase, deoxyribonuclease, a nonspecific lipase, and lysozyme. Enzyme determinations were carried out four months and six months after the infection with 15.5 X 10(7) bacilli per mouse. Clear differences between M. lepraemurium-infected and normal animals were observed at four months of infection, with all of the mentioned enzyme activities well above the normal values. At six months of infection, a tendency to decrease to normal values of the enzyme activities was observed. It is suggested that this biochemical activation of mouse peritoneal cells reflects the effect of the cell-mediated immune response triggered by the infection with the murine leprosy bacillus. M. lepraemurium-infected mice possess macrophages in a high state of biochemical activation; yet, they are unable to get rid of the infecting microorganism.
Efficient target tracking using mobile sensors (2011)

A mathematical model for tracking of a moving target by multiple mobile sensors in the framework of a partially observable Markov decision process is discussed. Applications include the use of a fleet of unmanned aerial vehicles for purposes such as search, surveillance, and target tracking. Computationally efficient approximate policies for controlling the mobile sensors are proposed, and a guarantee on their performance losses relative to that of the optimal policy is provided. Simulation results show that our proposed policies do perform close to the optimum for certain stationary models in which a mobile sensor can always move as fast as the target.
Optimum Forming Conditions for Incremental Tube Burring witha Bar Tool Using FE Simulation (2009)

Suitable tool path conditions for incremental tube burring with a bar tool are determined to obtain a uniform wall thickness distribution at the edge of a branched tube by an explicit finite element simulation. In the determination, an aluminum alloy tube, A5083-O, of 400 mm diameter and 6.0 mm wall thickness and a bar tool of 65 mm diameter are modeled. In this study, the second stage of incremental tube burring process is focused on, which is the crucial burring stage predominating the feasibility of burring process and product quality. As to the rocking condition of a bar tool at this stage, it is found that decreasing rocking angle by 5 degrees per cycle is suitable for preventing fracture and achieving high product accuracy. In addition, the simulation results show that an initial rocking angle of 45 degrees is effective in decreasing burring torque and wall thickness reduction ratio at the edge part of branched tube. This reveals that simulation is valid as a design tool for the process optimization of this multistage incremental forming.
Asymmetric induction in manganese(III)-based oxidative free-radical cyclizations of phenylmenthyl acetoacetates and 2,5-dimethylpyrrolidine acetoacetamides (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAsymmetric induction in manganese(III)-based oxidative free-radical cyclizations of phenylmenthyl acetoacetates and 2,5-dimethylpyrrolidine acetoacetamidesQingwei Zhang, Raju M. Mohan, Laura Cook, Sophia Kazanis, Daniel Peisach, Bruce M. Foxman, and Barry B. SniderCite this: J. Org. Chem. 1993, 58, 27, 7640–7651Publication Date (Print):December 1, 1993Publication History Published online1 May 2002Published inissue 1 December 1993https://pubs.acs.org/doi/10.1021/jo00079a006https://doi.org/10.1021/jo00079a006research-articleACS PublicationsRequest reuse permissionsArticle Views921Altmetric-Citations71LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
[Comparative pharmacokinetics and relative bioavailability of magnesium-containing drugs]. (2010)

Pharmacokinetics of magnesium ions after single peroral administration of Magnelis B6 and Magne B6 coated tablets (magnesium dose, 48 mg) was studied in rabbits. In the blood plasma, the level of magnesium ions was very low compared to the endogenous level, which did not allow the drug bioavailability to be reliable evaluated. At the same time, the level of magnesium ions was reliable determined in the daily urine of test animals. The relative bioavailability of magnesium for Magnelis B6 versus Magne B6 was estimated at 98.93 +/- 12.45% (average +/- SD).
Standardisation of a European measurement method for organic carbon and elemental carbon in ambient air: results of the field trial campaign and the determination of a measurement uncertainty and working range (2017)

The European Committee for Standardisation (CEN) Technical Committee 264 'Air Quality' has recently produced a standard method for the measurements of organic carbon and elemental carbon in PM<sub>2.5</sub> within its working group 35 in response to the requirements of European Directive 2008/50/EC. It is expected that this method will be used in future by all Member States making measurements of the carbonaceous content of PM<sub>2.5</sub>. This paper details the results of a laboratory and field measurement campaign and the statistical analysis performed to validate the standard method, assess its uncertainty and define its working range to provide clarity and confidence in the underpinning science for future users of the method. The statistical analysis showed that the expanded combined uncertainty for transmittance protocol measurements of OC, EC and TC is expected to be below 25%, at the 95% level of confidence, above filter loadings of 2 μg cm<sup>-2</sup>. An estimation of the detection limit of the method for total carbon was 2 μg cm<sup>-2</sup>. As a result of the laboratory and field measurement campaign the EUSAAR2 transmittance measurement protocol was chosen as the basis of the standard method EN 16909:2017.