gebhart/patrepeval huggingface dataset:
Addressing Cultural Diversity in Aged Care (2006)

Culturally and linguistically diverse population of Australia ageing more rapidly as the Australian Institute of Health and Welfare indicates that by 2011 nearly 23% Australians aged 65 and over will be from a culturally and linguistically diverse background (CALD). Most elderly people from CALD backgrounds access generalist aged care services provided in their local communities and there is a challenge from the providers of aged care services to ensure that they have policies and strategies in place to meet their needs.
Faculty Opinions recommendation of Cleavage site specificity and conformational selection in type I collagen degradation. (2010)

Excessive degradation of type I collagen is associated with a variety of human diseases such as arthritis, tumor metastasis, and atherosclerosis. Methods that further our understanding of collagenolysis may therefore provide insights into the mechanism of several important disorders. Prior experiments suggest that cleavage of collagen in vitro requires intact full-length collagenase, a multidomain protein containing both a catalytic and a hemopexin-like domain. In this work we demonstrate that type I collagen can be degraded at room temperature, a temperature well below the melting temperature of type I collagen, by collagenase deletion mutants that only contain the catalytic domain of the enzyme. Furthermore, these mutant enzymes hydrolyze the same peptide bond that is recognized by the corresponding full-length enzymes. Hence enzyme specificity at room temperature is achieved without the hemopexin-like domain. We demonstrate that these findings can be explained in light of a conformational selection mechanism that dictates that collagenases preferentially recognize and cleave preformed partially unfolded states of collagen. PMID: 20394413
BOTULINUM TOXIN TYPE A NORMALIZES ALTERATIONS IN UROTHELIAL ATP AND NO RELEASE CAUSED BY CHRONIC SPINAL CORD INJURY (2008)

You have accessJournal of Urology1 Apr 2008BOTULINUM TOXIN TYPE A NORMALIZES ALTERATIONS IN UROTHELIAL ATP AND NO RELEASE CAUSED BY CHRONIC SPINAL CORD INJURY Christopher P Smith, David A Gangitano, Alvaro Munoz, Nilson A Salas, Timothy B Boone, KR Aoki, Joseph Francis, and George T Somogyi Christopher P SmithChristopher P Smith More articles by this author , David A GangitanoDavid A Gangitano More articles by this author , Alvaro MunozAlvaro Munoz More articles by this author , Nilson A SalasNilson A Salas More articles by this author , Timothy B BooneTimothy B Boone More articles by this author , KR AokiKR Aoki More articles by this author , Joseph FrancisJoseph Francis More articles by this author , and George T SomogyiGeorge T Somogyi More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(08)60226-8AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "BOTULINUM TOXIN TYPE A NORMALIZES ALTERATIONS IN UROTHELIAL ATP AND NO RELEASE CAUSED BY CHRONIC SPINAL CORD INJURY." The Journal of Urology, 179(4S), p. 77 © 2008 by American Urological AssociationFiguresReferencesRelatedDetails Volume 179Issue 4SApril 2008Page: 77 Advertisement Copyright & Permissions© 2008 by American Urological AssociationMetricsAuthor Information Christopher P Smith More articles by this author David A Gangitano More articles by this author Alvaro Munoz More articles by this author Nilson A Salas More articles by this author Timothy B Boone More articles by this author KR Aoki More articles by this author Joseph Francis More articles by this author George T Somogyi More articles by this author Expand All Advertisement PDF downloadLoading ...
Propranolol in the treatment of rage and violent behavior in patients with chronic brain syndromes (1981)

The authors successfully treated four patients who had irreversible CNS lesions and socially disabling aggressiveness and outbursts of rage, which had not been affected by high doses of major tranquilizers or anticonvulsants, with 320-520 mg/day of propranolol. Disorientation, memory impairment, and psychotic thought processes associated with the CNS lesions were not altered by the propranolol.
Luteinizing Hormone (LH) Drives Diverse Intracellular Calcium Second Messenger Signals in Isolated Porcine Ovarian Thecal Cells: Preferential Recruitment of Intracellular Ca2+ Oscillatory Cells by Higher Concentrations of LH* (2000)

Abstract The present study examines Ca2+ second messenger signaling driven by LH in isolated porcine thecal cells. To this end, we implemented semiquantitative fluorescent (fura-2) videomicroscopic imaging of single thecal cells in vitro. Stimulation of 388 cells with LH (5 μg/ml) elicited an intracellular Ca2+ ([Ca2+]i) signal in 85± 5.3% of individual thecal cells (n = 11 experiments). Among 337 LH-responsive cells, we identified four predominant temporal modes of [Ca2+]i signaling: 1)[ Ca2+]i oscillations with periodicities of 0.5 to 4.5 min−1 (63 ± 4.5%), 2) a[ Ca2+]i spike followed by a sustained plateau (17 ± 2.6%), 3) a [Ca2+]i spike only (5.8 ± 2.6%); and 4) a [Ca2+]i plateau only (3.8 ± 1.5%). The prevalence, but not the amplitude or frequency, of LH-induced [Ca2+]i oscillations in thecal cells was dependent on the agonist concentration. Reduced availability of extracellular Ca2+ induced by treatment with EGTA or cobaltous chloride did not block the initiation, but reversibly abolished ongoing [Ca2+]i oscillations (72% of cells) or increased the mean[ Ca2+]i interspike periodicity from 1.09± 0.16 to 0.59 ± 0.07 min−1 (P&amp;lt; 0.05). Putative phospholipase C inhibition with U-73122 (10μ m) also abolished or frequency-damped LH-driven[ Ca2+]i oscillations in 95 ± 4.7% of cells. [Ca2+]i oscillations in thecal cells were not abrogated by overnight pretreatment with pertussis toxin. We conclude that 1) thecal cells (unlike earlier findings in granulosa cells) manifest a diverse array of [Ca2+]i signaling responses to LH at the single cell level; 2) LH can dose dependently recruit an increasing number of individually[ Ca2+]i oscillating thecal cells; 3) extracellular Ca2+ is required for LH to sustain (but not initiate) frequent and high amplitude [Ca2+] oscillations in thecal cells; and 4) these signaling actions of LH are mediated via phospholipase C, but not a pertussis-toxin sensitive mechanism. Accordingly, the present data extend the apparent complexity of LH-induced [Ca2+]i second messenger signaling and identify at the single cell level LH’s dose-responsive drive of[ Ca2+]i oscillations in gonadal cells.
Extended Treatment of Severe Coronary Artery Disease (1969)

JOHNSON, W. DUDLEY M.D.; FLEMMA, ROBERT J. M.D.; LEPLEY, DERWARD JR., M.D.; ELLISON, EDWIN H. M.D. Author Information
EM and Power SCA-Resilient AES-256 Through >350× Current-Domain Signature Attenuation and Local Lower Metal Routing (2020)

Mathematically secure cryptographic algorithms, when implemented on a physical substrate, leak critical “side-channel” information, leading to power and electromagnetic (EM) analysis attacks. Circuit-level protections involve switched capacitor, buck converter, or series low-dropout (LDO) regulator-based implementations, each of which suffers from significant power, area, or performance tradeoffs and has only achieved a minimum traces to disclosure (MTD) of 10M till date. Utilizing an in-depth white-box model, this work, for the first time, focuses on signature suppression in the current domain, which provides an Attenuation2 enhancement in MTD, leading to orders of magnitude improvement in both power and EM side-channel analysis (SCA) immunities. Using a combination of current-domain “signature attenuation” (CDSA) along with local lower level metal routing, the critical correlated information in the crypto current is significantly suppressed before it reaches the supply pin. Especially, to prevent the EM leakage from its source (metal layers carrying the correlated crypto current acting as antennas), this work embraces lower level metal routing of the CDSA embedding the crypto-IP so that the signature becomes highly suppressed before it passes through the higher metal layers (which radiates significantly) to connect to the external pin. The 65-nm CMOS test chip contains both protected and unprotected parallel AES-256 implementations, running at a clock frequency of 50 MHz. Test vector leakage assessment (TVLA) on the protected CDSA-AES, demonstrated with on-chip measurements for the first time, shows that the higher level metal layers leak significantly more compared with the lower level metal routing. Correlational power and EM analysis (CPA/CEMA) attacks on the unprotected implementation were able to extract the secret key within 8k and 12k traces, respectively, while the protected CDSA-AES could not be broken even after 1B encryptions for both power and EM SCA, evaluated both in the time and frequency domains, showing an improvement of 100× over the prior state-of-the-art countermeasures with comparable power and area overheads.
Comparison of Cytocompatibility and Anticancer Properties of Traditional and Green Chemistry-Synthesized Tellurium Nanowires [Corrigendum] (2021)

[This corrects the article DOI: 10.2147/IJN.S175640.].
The development, use, and optimization of sortase-tag expressed protein ligation (2015)

Molecular imaging is an emerging field that seeks to combine the mechanistic detail of biochemical assays with the the broad phenotypic data obtained from non-invasive medical imaging. A cornerstone of molecular imaging is the ability to chemically attach a contrast-inducing payload to a targeting ligand, a protein that binds tightly and specifically to the targeted cell population. There are currently many approaches to bioconjugation. Chemical approaches have broad applicability, but lack the site-specificity and efficiency desired for contrast agent generation. Enzymatic techniques are quantitative, efficient, and site-specific, but often have limited scope and can add significant bulk to the targeting ligand or require additional downstream purification steps. In this work, we create a novel bioconjugation and protein purification technique, Sortase-Tag Expressed Protein Ligation (STEPL). By fusing the active domain of S. aureus Sortase A to the targeting ligand as part of a greater chimeric protein, we are able to combine protein purification and the C-terminal bioconjugation of that protein into a single step. Using a mass-action kinetics model, we prove that this results in a modular, efficient system capable of producing high-purity conjugated protein. We then use the system to generate contrast agents for fluorescent and magnetic imaging studies. The modularity of the STEPL system allows us to create an array of monospecific and bispecific targeting ligand dimers, linked by two different spacer regions. The dimers' binding properties are probed and they are used to successfully bind and label cells, with the bispecific proteins enhancing contrast of a cell line that is positive for both targets. Finally the STEPL system is subjected to a number of directed evolution approaches and screened for a clone that could further improve STEPL's efficiency and yield.
Integrity Measurement Model Based on Trusted Virtual Platform (2010)

A secure and trusted execution environment is a fundamental requirement for distributed network, so that the integrity of service provider platform should be verified prior to services' distribution in order to assure that the platform is free from a malicious modification and attack. In this paper, we proposed an implementation of trusted execution environment based on the combination of trusted computing and virtualization technology. On the service provider's platform, from the very beginning of Virtual Machine Monitor (VMM) was booted to the execution environment was set up, all of the platform status changes has been recorded into Platform Configuration Register (PCR) and reported to remote service requester, which make it sure about the trustworthy of the result. Furthermore, the VM image was leveraged to make the execution environment constructed more flexible. Analysis shows our method is efficient and secure.
Determine Weight of Hot Metal Car Using Strain Gage Method (2005)

In certain situations, train car containers that carry hot metal have been overfilled, which necessitated the replacement of very costly car parts. Therefore, it is desirable to predict the amount of fluid needed at all times in order to know when to divert the flow of molten steel from the car. This study showed that the level of fluid in a container can be controlled even when the amount of fluid inside the container is not visible. When strain gages are effectively installed they can be used to continuously calculate the weight of a system as the strain increases, although only the final total weight is of concern. Strain gages can be positioned in safe locations on the spanner bolster of a hot metal car. The gages are installed such that the thermal and axial strains cancel out, ultimately leaving only the value for the weight of the loaded car. Once the gages are installed, they are calibrated when the system is full. For all subsequent loading periods, the strain gages report a linear strain increasing until it is equal to the original full calibration value. This then signals the operator to divert the flow of steel. If the inside of the container deteriorates over time, the strain that governs the shutoff remains the same although the fluid level is slightly lower. In the event of skull (leftover steel in the container), the maximum strain remains the same and the final volume is lower than the initial calibration condition. The objective in all cases is to avoid overflow of fluid from the car. This investigation showed that the amount of fluid in a train car that carries molten steel can be known at all times during the filling process. It is supported with manual calculations, finite element analyses, and laboratory experiments.
Supplementary Figure from Assessment of Androgen Receptor Splice Variant-7 as a Biomarker of Clinical Response in Castration-Sensitive Prostate Cancer (2023)

Supplementary Figure from Assessment of Androgen Receptor Splice Variant-7 as a Biomarker of Clinical Response in Castration-Sensitive Prostate Cancer
Position sensorless control of the Reluctance Synchronous Machine considering High Frequency inductances (2007)

Position sensorless control of the reluctance synchronous machine (RSM) at zero and low speed is possible using high frequency (HF) carrier injection. The standard d-q model of the RSM reveals greatly varying machine parameters for different working points of fundamental current: this fact needs to be taken into account in the design of the fundamental current controller to ensure stability. Similarly, the HF machine parameters vary greatly and should be considered in the demodulation scheme for the estimated rotor position. This paper shows that the effective HF inductances are different to the standard fundamental model inductances, how they are influenced by saturation and how this knowledge can be used to ensure stable and reliable sensorless control.
Concise Review: Sowing the Seeds of a Fruitful Harvest: Hematopoietic Stem Cell Mobilization (2013)

Hematopoietic stem cell transplantation is the only curative option for a number of malignant and nonmalignant diseases. As the use of hematopoietic transplant has expanded, so too has the source of stem and progenitor cells. The predominate source of stem and progenitors today, particularly in settings of autologous transplantation, is mobilized peripheral blood. This review will highlight the historical advances which led to the widespread use of peripheral blood stem cells for transplantation, with a look toward future enhancements to mobilization strategies.
Salivary Proteome and Its Genetic Polymorphisms (2007)

Salivary diagnostics for oral as well as systemic diseases is dependent on the identification of biomolecules reflecting a characteristic change in presence, absence, composition, or structure of saliva components found under healthy conditions. Most of the biomarkers suitable for diagnostics comprise proteins and peptides. The usefulness of salivary proteins for diagnostics requires the recognition of typical features, which make saliva as a body fluid unique. Salivary secretions reflect a degree of redundancy displayed by extensive polymorphisms forming families for each of the major salivary proteins. The structural differences among these polymorphic isoforms range from distinct to subtle, which may in some cases not even affect the mass of different family members. To facilitate the use of modern state-of-the-art proteomics and the development of nanotechnology-based analytical approaches in the field of diagnostics, the salient features of the major salivary protein families are reviewed at the molecular level. Knowledge of the structure and function of salivary gland-derived proteins/peptides has a critical impact on the rapid and correct identification of biomarkers, whether they originate from exocrine or non-exocrine sources.
Silicon Mirage: The Art and Science of Virtual Reality (1992)

An introduction to virtual reality covers every aspect of the revolutionary new technology and its many possible applications, from computer games to air traffic control. Original. National ad/promo.
Properties of the Hong Kong influenza virus. I. General characteristics of the Hong Kong virus. (1969)

Biological properties of the Hong Kong influenza variants are described in relation to the isolation and identification of strains, sensitivity to nonspecific inhibitors, and serological diagnosis. Hong Kong virus strains were readily isolated in both eggs and monkey-kidney tissue cultures and were identified by haemagglutination-inhibition (HI) with chicken erythrocytes. The morphology, soluble antigen, and neuraminidase of Hong Kong isolates were similar to those of earlier A2 Asian influenza strains. Hong Kong haemagglutinins were related in varying degrees to previous human A2 and animal influenza viruses.The sensitivity of Hong Kong isolates to nonspecific haemagglutination inhibitors in serum varied widely. From least to most inhibitory, the ranking of sera of 8 animal species tested was: monkey, goat, chicken, human, rabbit, ferret, guinea-pig and horse. The same sera were treated with heat, trypsin, periodate, receptor-destroying enzyme and kaolin to determine the most effective way of removing nonspecific inhibitors. The results varied with the animal species involved.The A2 Asian antigen was nearly as effective as Hong Kong antigen in detecting antibody rises by HI tests. HI tests with either antigen were more efficient than complement-fixation tests for serodiagnosis of Hong Kong influenza, but for maximum efficiency both tests were required.
Aberrant Akt2 signaling in the RPE may contribute to retinal fibrosis process in diabetic retinopathy (2023)

Diabetic Retinopathy (DR) is a complication of diabetes that causes blindness in adults. Retinal fibrosis is closely associated with developing proliferative diabetic retinopathy (PDR). Clinical studies have shown that fibrotic membranes exhibit uncontrolled growth in PDR and contribute to retinal detachment from RPE cells, ultimately leading to vision loss. While anti-VEGF agents and invasive laser treatments are the primary treatments for PDR, retinal fibrosis has received minimal attention as a potential target for therapeutic intervention. Therefore, to investigate the potential role of Akt2 in the diabetes-induced retinal fibrosis process, we generated RPE-specific Akt2 conditional knockout (cKO) mice and induced diabetes in these mice and Akt2<sup>fl/fl</sup> control mice by intraperitoneal injection of streptozotocin. After an 8-month duration of diabetes (10 months of age), the mice were euthanized and expression of tight junction proteins, epithelial-mesenchymal transition (EMT), and fibrosis markers were examined in the RPE. Diabetes induction in the floxed control mice decreased levels of the RPE tight junction protein ZO-1 and adherens junction proteins occludin and E-cadherin; these decreases were rescued in Akt2 cKO diabetic mice. Loss of Akt2 also inhibited diabetes-induced elevation of RNA and protein levels of the EMT markers Snail/Slug and Twist1 in the RPE as compared to Akt2<sup>fl/fl</sup> diabetic mice. We also found that in Akt2 cKO mice diabetes-induced increase of fibrosis markers, including collagen IV, Connective tissue growth factor (CTGF), fibronectin, and alpha-SMA was attenuated. Furthermore, we observed that high glucose-induced alterations in EMT and fibrosis markers in wild-type (WT) RPE explants were rescued in the presence of PI3K and ERK inhibitors, indicating diabetes-induced retinal fibrosis may be mediated via the PI3K/Akt2/ERK signaling, which could provide a novel target for DR therapy.
Synthesis and biological effects of new derivatives of benzotriazole as antimicrobial and antifungal agents (2002)

Abstract Derivatives of 2‐aminothiophene‐3‐carbonitrile, 2‐thioxopyridine‐3‐carbonitrile, 1,8‐naphthyridine‐2‐one, thieno[2,3‐ b ]pyridine‐5‐carbonitrile and thieno[2,3‐ d ]pyrimidine incorporating with a 1 H ‐benzo‐triazole moiety or 1,3,4‐thiadiazole derivatives incorporating with a benzotriazol‐1‐ylmethyl group have been synthesized and tested for antimicrobial and antifungal activities. The structures of the newly synthesized compounds have been established on the basis of their analytical and spectral data.
ChemInform Abstract: Tellurium Tetrachloride as an Efficient Chlorinating Agent for Di‐ (I) or Trialkyl Phosphites (III): Novel Synthesis of Dialkyl Chlorophosphates (II). (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Photonic crystal based microscale flow cytometry (2014)

Here we propose a new design of an on-chip micro-flow cytometry based on photonic crystals. When individual cells flow tangential to the crystal surface, the transmission of the light through the photonic crystal changes depending on the presence or absence of the cells and their size and shape. This system was modeled using OptiFDTD, where transmission spectra were extracted. Initially, the potential for cell counting has been demonstrated. Then, for cells with differing shape a direct relation between signal distribution and cell shape has been found.
End Points for Colon Cancer Adjuvant Trials: Observations and Recommendations Based on Individual Patient Data From 20,898 Patients Enrolled Onto 18 Randomized Trials From the ACCENT Group (2007)

DFS outcomes after 2- or 3-year median follow-up are excellent predictors of 5-year OS. DFS outcomes are appropriate for trials in which the majority of patients are stage III. DFS after 2- or 3-year median follow-up should be considered as the primary end point in future colon adjuvant trials.