gebhart/patrepeval huggingface dataset:
The Fas-Fas ligand system and other modulators of apoptosis in the cornea. (1996)

The Fas system (Fas and Fas ligand) modulators and final common pathway mediators of apoptosis are expressed in corneal cells. The distribution of Fas (epithelial, keratocyte, and endothelial cells) and Fas ligand (epithelial and endothelial cells) protein expression in fresh-frozen corneal tissue suggests that Fas ligand expressed in corneal epithelial and endothelial cells modulates functions in keratocyte cells and, possibly, autocrine-juxtacrine functions in epithelium and endothelium. The Fas-Fas ligand system is expressed in the cornea and could have important functions in normal corneal physiology and in the pathophysiology of corneal disease, including modulation of keratocyte apoptosis after epithelial injury.
EXPOSURE OF MICE TO UV‐B RADIATION SUPPRESSES DELAYED HYPERSENSITIVITY TO Candida albicans (1989)

Groups of mice were exposed to a single dose of UV radiation before or after immunization with Candida albicans. The delayed type hypersensitivity (DTH) response was markedly depressed in all UV-irradiated groups. Exposure of mice to UV radiation before sensitization induced splenic suppressor cells that, upon transfer to normal recipients, impaired the induction of DTH to Candida. In contrast, exposure of mice to UV radiation after sensitization interfered with elicitation of the DTH response, but this suppression was not transferable. These studies demonstrate that immunity to Candida albicans in mice is impaired by exposure to UV radiation and that two separate mechanisms may be involved.
Pseudomonas aeruginosa biosurfactant production in continuous culture with glucose as carbon source (1984)

Rsan-ver, a strain of Pseudomonas aeruginosa isolated at this department, was used for the development of a continuous process for biosurfactant production. The active compounds were identified as rhamnolipids. A final medium for production was designed in continuous culture by means of medium shifts, since the formation of surface-active compounds was decisively influenced by the composition and concentration of the medium components. In the presence of yeast extract, biosurfactant production was poor. For the nitrogen-source nitrate, which was superior to ammonium, an optimum carbon-to-nitrogen ratio of ca. 18 existed. The iron concentration needed to be minimized to 27.5 micrograms of FeSO4 X 7H2O per g of glucose. A carbon-to-phosphate ratio below 16 yielded the maximum production of rhamnolipids. The final productivity dilution rate diagram indicated that biosurfactant production was correlated to low growth rates (dilution rate below 0.15 h-1). With a medium containing 18.2 g of glucose liter-1, a biosurfactant concentration (expressed as rhamnolipids) of up to 1.5 g liter-1 was obtained in the cell-free culture liquid.
The Effect of a Carbohydrate-Rich Beverage on Mood, Appetite, and Cognitive Function in Women With Premenstrual Syndrome (1995)

The results suggest that the psychological and appetitive symptoms of PMS can be relieved after consuming a specially-formulated, carbohydrate-rich beverage known to increase serum tryptophan levels.
<title>Horizontal model fusion paradigm</title> (1996)

In navigation and tracking problems, the identification of an appropriate model of vehicular or target motion is vital to most practical data fusion algorithms. The true system dynamics are rarely known, and approximations are usually employed. Since systems can exhibit strikingly different behaviors, multiple models may be needed to describe each of these behaviors. Current methods either use model switching (a single process model is chosen from the set using a decision rule) or consider the models as a set of competing hypothesis, only one of which is 'correct'. However, these methods fail to exploit the fact that all models are of the same system and that all of them are, to some degree, 'correct'. In this paper we present a new paradigm for fusing information from a set of multiple process models. The predictions from each process model are regarded as observations which are corrupted by correlated noise. By employing the standard Kalman filter equations we combine data from multiple sensors and multiple process models optimally. There are a number of significant practical advantages to this technique. First, the performance of the system always equals or betters that of the best estimator in the set of models being used. Second, the same decision theoretic machinery can be used to select the process models as well as the sensor suites.
Mitochondrial Complex I Is a Global Regulator of Secondary Metabolism, Virulence and Azole Sensitivity in Fungi (2016)

[This corrects the article DOI: 10.1371/journal.pone.0158724.].
Relevance of Micrometastases and Targeting the Bone Marrow Niche with Zoledronic Acid in Breast Cancer (2012)

During the course of cancer metastasis development, invasive tumor cells circulate through the blood stream and disseminate to other tissues. Circulating and disseminated tumor cells (CTCs and DTCs, respectively) may be the source of local and distant metastases and are a promising target for anticancer therapy. Multiple studies have shown that the detection of DTCs or CTCs correlates with increased risk of disease recurrence, suggesting that reducing the prevalence and persistence of these cells is clinically relevant. The development of metastases is a multistep process that involves complex biologic processes and a multitude of growth factors. The bone marrow provides a portion of these growth factors and a nutrient-rich microenvironment in which dormant cancer cells can survive and transition to metastasis- initiating cells. The molecular interactions between DTCs and the bone marrow microenvironment enable DTCs to evade cytotoxic chemotherapy, allowing them to lie dormant for extended periods of time before becoming active and metastasizing to secondary sites. Alteration of the bone marrow microenvironment with antiresorptive agents, such as bisphosphonates, may render the bone marrow less suitable for cancer cell growth, possibly interfering with the metastatic cascade. Clinical studies have shown that the nitrogen-containing bisphosphonate zoledronic acid can reduce the persistence and prevalence of DTCs in patients with breast cancer, suggesting that zoledronic acid may improve clinical outcomes. Targeting the metastatic niche by altering the microenvironment in the bone marrow may be an effective anticancer strategy.
Myelin Basic Protein: A Component of Circulating Immune Complexes in Multiple Sclerosis (1983)

Myelin basic protein (MBP) is an antigenic component of circulating immune complexes (CIC) in patients with multiple sclerosis (MS). Immune complexes were isolated from the sera by adsorption to Raji cells and then acid eluted. Final identification of MBP from Raji eluates was done by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) followed by MBP radioimmunoassay (RIA) of gel eluates and by an immunoblot technique.
Design of a 20-Amino Acid, Three-Stranded β-Sheet Protein (1998)

A 20-residue protein (named Betanova) forming a monomeric, three-stranded, antiparallel beta sheet was designed using a structural backbone template and an iterative hierarchical approach. Structural and physicochemical characterization show that the beta-sheet conformation is stabilized by specific tertiary interactions and that the protein exhibits a cooperative two-state folding-unfolding transition, which is a hallmark of natural proteins. The Betanova molecule constitutes a tractable model system to aid in the understanding of beta-sheet formation, including beta-sheet aggregation and amyloid fibril formation.
Notochord signals control the transcriptional cascade of myogenic bHLH genes in somites of quail embryos (1996)

Microsurgical, tissue grafting and in situ hybridization techniques have been used to investigate the role of the neural tube and notochord in the control of the myogenic bHLH genes, QmyoD, Qmyf5, Qmyogenin and the cardiac alpha-actin gene, during somite formation in stage 12 quail embryos. Our results reveal that signals from the axial neural tube/notochord complex control both the activation and the maintenance of expression of QmyoD and Qmyf5 in myotomal progenitor cells during the period immediately following somite formation and prior to myotome differentiation. QmyoD and Qmyf5 expression becomes independent of axial signals during myotome differentiation when somites activate expression of Qmyogenin and alpha-actin. Ablation studies reveal that the notochord controls QmyoD activation and the initiation of the transcriptional cascade of myogenic bHLH genes as epithelial somites condense from segmental plate mesoderm. The dorsal medial neural tube then contributes to the maintenance of myogenic bHLH gene expression in newly formed somites. Notochord grafts can activate ectopic QmyoD expression during somite formation, establishing that the notochord is a necessary and sufficient source of diffusible signals to initiate QmyoD expression. Myogenic bHLH gene expression is localized to dorsal medial cells of the somite by inhibitory signals produced by the lateral plate and ventral neural tube. Signaling models for the activation and maintenance of myogenic gene expression and the determination of myotomal muscle in somites are discussed.
Robust WMMSE Precoder With Deep Learning Design for Massive MIMO (2023)

In this paper, we investigate the downlink robust precoding with imperfect channel state information (CSI) for massive multiple-input-multiple-output (MIMO) communications. With the estimated channel and channel error statistics, the general design of the robust precoder is to maximize the ergodic sum rate subject to the total transmit power constraint. To make the problem more tractable, we find a lower bound of the ergodic sum rate and propose the robust weighted minimum mean-squared-error (WMMSE) precoder to maximize the bound. We characterize the structure of the precoding vectors by low-dimensional parameters, which are learned directly from the available CSI through a neural network. As such, the precoding vectors can be immediately computed without iterations. To extend the deep learning design to multi-antennas users, we present a flexible approach that allows the various antenna configurations at the user side to be handled. Simulation results show that the deep learning design can significantly reduce the computational complexity compared with the existing precoder designs while achieving near optimal performance.
The parthenocarpic fruit (pat) mutant of tomato (Lycopersicon esculentum Mill.) sets seedless fruits and has aberrant anther and ovule development (1998)

Among the different sources of genetic parthenocarpy described in tomato, the mutation referred to as parthenocarpic fruit (pat) is of particular interest because of its strong expressivity and because it confers earlier ripening, higher fruit set and enhanced fruit quality. As a pleiotropic effect, pat flowers have aberrantly developing androecia and reduced male and female fertility. In this work we extend the early description of the pat phenotype by investigating the expression of parthenocarpy in three different environments and by using light and scanning electron microscopy to analyse the development of male and female floral organs. The degree of parthenocarpy was high in the three experimental environments and was characterised by a precocious initiation of ovary growth to pre-anthesis floral stages. Aberrations in anther development were evident at flower bud stages and resulted in shorter, irregular and teratoid organs. Ectopic production of carpel-like structures bearing external ovules was evident in the most severely altered androecia. Analysis of ovule development revealed that a fraction of pat ovules becomes aberrant from very early stages, having defective integument growth. Meiosis was irregular in aberrant ovules and megaspore or gamete production was severely hampered. The described pat syndrome suggests that parthenocarpy in this mutant could be a secondary effect of a gene controlling, at early stages, organ identity and development.
Unipolar Diffusion Charging of Ultrafine Aerosols (1988)

Experimental data are reported for unipolar diffusion charging of NaCl and Ag aerosols in the 0.004- to 0.075-μm-diameter range. Monodisperse, uncharged particles were exposed to unipolar positive ions produced by a corona discharge. The nt product was varied between 3 × 106 and 1 × 107 (ions/cm3) (s), where n is the unipolar ion concentration and t is the charging time. The resulting aerosol charged fraction was measured by using a single-particle-counting condensation nucleus counter in conjunction with an electrostatic condenser. From the measured charged fraction and the known charging parameters, the combination coefficient between the neutral particles and the positive ions are obtained. Measurements are then compared with the available charging theories. It is found that the theory of Marlow and Brock best predicts charging rates in the ultrafine particle size range. Above 10 nm, the data approach the theory of Fuchs consistent with the experimental observation of Adachi et al.
Cosmology on the Back of an Envelope (2017)

In the twentieth century, mathematical models of the cosmos proliferated unconstrained by sufficient evidence to choose among them. But more recently, a number of large observational programs have redefined the parameters of cosmology: In the twenty-first century, spatial curvature is out, and the cosmological constant is in. A straightforward Newtonian model incorporating these points has been known for decades and is updated here. An explicit, closed-form solution is presented with useful formulas and graphs. A physical interpretation of the cosmological constant is suggested.
Vocal sonification of pathologic EEG features (2006)

&lt;center&gt;&lt;img\nsrc="https://pub.uni-bielefeld.de/download/2017291/2920031"\nwidth="300" style="float:right;" &gt;&lt;/center&gt;\nWe introduce a novel approach in EEG data sonification for process monitoring and exploratory as well as comparative data analysis. The approach uses an excitory/articulatory speech model and a particularly selected parameter mapping to obtain auditory gestalts (or auditory objects) that correspond to features in the multivariate signals. The sonification is adaptable to patient-specific data patterns, so that only characteristic deviations from background behavior (pathologic features) are involved in the sonification rendering. Thus the approach combines data mining techniques and case-dependent sonification design to give an application-specific solution with high potential for clinical use. We explain the sonification technique in detail and present sound examples from clinical data sets.
Preparation and Characterization of Magnetically Responsive Bacterial Polyester Based Nanospheres for Cancer Therapy (2012)

Polyhydroxyalkanoates (PHA) are natural, thermoplastic polyesters and due to their biocompatible and biodegradable properties they are good alternatives for the production of scaffolds for engineered tissues or nanoparticles for drug delivery. As a member of polyhydroxyalkanoate family, polyhydroxybutyrates (PHB) have been widely used as a biomaterial for in vitro and in vivo studies since their mechanical properties are very similar to conventional plastics. By using multi-emulsion technique, iron oxide particles were coated with polyhydroxybutyrate (PHB) polymer synthesized from Alcaligenes eutrophus bacteria and the magnetic carrier system was prepared accordingly. The bare nanoparticles and magnetic nanoparticles were morphologically, structurally and magnetically characterized by using Scanning electron microscope (SEM) and Atomic force microscope (AFM); Fourier Transform Infrared Spectrometry (FTIR), and Electron Spin Resonance (ESR) and Vibrating Sample Magnetometer (VSM) techniques, respectively. Particle size of PHB nanoparticles was determined by Zeta Sizer. It was found that the smallest particles were in the range of 239.43 +/- 5.25 nm in diameter. Concanavalin-A (Con-A) was used for targeting the cancer cells while etoposide was used as drug. Con-A and etoposide were loaded onto the particles. Release studies of etoposide were evaluated and the system was optimized for the further in vivo applications. Finally different formulation magnetic PHB nanoparticles cytotoxicity were evaluated in cell culture studies and used HeLa cell line (cervical cancer cells) as a cancer cells and L929 cells (mouse fibroblast cells) as a non-cancer cell line.
A Multi-Directions Algorithm for Edge Detection Based on Fuzzy Mathematical Morphology (2006)

This paper brings forward a multi-directions algorithm for image edge detection based on fuzzy mathematical morphology. In this algorithm, we integrate the multi-directions characteristic of structure elements and fuzzy image characteristic into mathematical morphology, and then use mathematical morphology to detect image edge. It is indicated from experiment that this algorithm has succeeded in edge detection, and it has better effect than other traditional arithmetic operators of edge detection.
30 Calcium and Phosphorus Metabolism and Bone Disease in Uremia (1970)

KLEEMAN, CHARLES R.; MASSRY, SHAUL G.; COBURN, JACK W.; POPOVTZER, MORDECAI M. Author Information
Assessment of fetal radiation dose during maternal sentinel lymph node mapping for breast cancer (2005)

541 Background: Pregnancy is considered a contraindication to sentinel lymph node (SLN) mapping due to the possible detrimental effects of technetium-99m sulfur colloid (TSC) radiation and isosulfan blue dye on the developing fetus. As a result, pregnant women with breast cancer must undergo complete axillary lymph node dissection for axillary staging. The U.S. Nuclear Regulatory Commission has established an occupational dose limit of 500 mrem over the gestation period (recommended at the rate of no more than 50mrem/month) for a declared pregnant woman. The purpose of this study was to assess the amount of radiation exposure to the fetus during breast surgery involving SLN mapping using TSC and to compare this exposure to federal regulatory limits. Methods: A review was performed of a prospective SLN database of 1,021 patients who underwent SLN mapping using unfiltered TSC from January 2000 to April 2001. Two separate techniques were used with respect to isotope SLN mapping: either 0.1 mCi TSC particles were injected intradermally superficial to the tumor site on the same day as surgery or 0.5 mCi TSC particles were injected on the day before surgery. Standard, FDA-reviewed, dose assessment methodologies (OLINDA-EXM 1.0) were applied to a standard reference model and to the median patient characteristics from this database to develop a patient-population phantom (non-pregnant and at 3 stages of pregnancy: 3 mos, 6 mos, and 9mos). It was assumed that the injection site remained in the breast until complete decay of the technetium-99m, regardless of the definitive breast procedure. Results: See Table. Conclusions: Based on these conservative estimates, the maximal fetal doses during breast surgery involving TSC for SLN mapping are small and well below levels associated with risk concerns. At these activity levels (0.1 mCi and 0.5 mCi), pregnancy should not be considered a contraindication for SLN mapping in breast cancer utilizing TSC. No significant financial relationships to disclose.
ACCOMMODATIVE MICROFLUCTUATION IN ASTHENOPIA CAUSED BY ACCOMMODATIVE SPASM (2001)

Our results suggested that the ciliary muscle was also actively working in asthenopia caused by accommodative spasm even if the patient was looking at a distant target.
Humoral and cellular responses after COVID-19 vaccination in anti-CD20-treated lymphoma patients (2021)

Three reports address the protection of the vulnerable population of patients with hematologic malignancies in the face of the ongoing COVID pandemic. The reports suggest that some patients who fail to mount a B-cell response to vaccine may nevertheless have protective T cell responses. As a group, these reports suggest that patients should continue to be immunized with additional doses to attempt to improve immune response but that they need to maintain the precautions recommended for the unvaccinated.
Stress Analysis on Ultra Thin Ground Wafers (2007)

Grinding wafers is a well established process for thinning wafers down to 100 μm for use in smart cards and stacking chips. As a result of the mechanical process, the wafer backside is compressively stressed. In this paper, the authors investigate the influence of the backside induced stress in ultra thin Si wafers (~20μm). Such aggressive thinning is a requirement for high density vias interconnect, stacked die packaging and flexible electronics.
Cutaneous metastasis of pancreatic carcinoma as an initial symptom in the lower extremity with obstructive lymphedema treated by physiotherapy and lymphaticovenous shunt: a case report, review, and pathophysiological implications. (2010)

Cutaneous metastasis from pancreatic cancer is relatively rare as an initial symptom, and it is generally localized on the periumbilical area that is known as Sister Mary Joseph's nodule. We report a rare case of a 49-year-old female who developed cutaneous metastasis of pancreatic cancer as an initial symptom. The patient was referred to our department for treatment of lymphedema due to surgical treatment of cervical cancer and underwent combined physiotherapy and, 2 months later, a lymph venous anastomosis (LVA) for treatment of the lymphedema. Two months after the operation, she developed erythema on her right leg which spread from the leg to the groin in series. This pattern corresponded to the direction of lymph drainage, which may have been enhanced by the conservative physiotherapy and LVA treatments. These facts suggest a possible relationship between cutaneous metastasis of carcinoma and treatment for lymphedema. Alternatively, the lymphedematous limb may be a privileged site for cancer growth, and metastatic seeding could have taken place from pre-existing hematogenous spread at the time of operation.
Percutaneous Closure of Multiple Secundum Atrial Septal Defects Using 3 Amplatzer Atrial Septal Occluder Devices (2008)

A previously healthy 12-year-old boy was admitted to the hospital with acute pneumonitis. On admission, a heart murmur was detected. The transthoracic echocardiogram showed multiple secundum atrial septal defects with left-toright shunt and signs of right ventricular volume overload. He underwent right cardiac catheterization and transesophageal echocardiogram (transesophageal echocardiography): 3 sizeable atrial septal defects (anterosuperior, measuring 10 mm; posterior, 9 mm; anteroinferior, 6 mm) were closed with 3 Amplatzer atrial septal occluder devices, measuring 10, 9, and 6 mm (Figures A good result was achieved, with no residual shunt across the atrial septum and no complications. The live transthoracic 3D (Figures