gebhart/patrepeval huggingface dataset:
Assessment of the Reliability of the SPAC Method in Urban Areas (2015)

Summary We have carried out several long-term measures of seismic noise with triangular arrays of broad-band seismic sensors, to investigate the reliability of the SPAC method in urban areas. We investigate the stationary and anisotropy of the microtremor wave field. We have found that the anisotropy of the microtremor wave field can be evaluated analyzing the HVNSR as function the azimuth. Furthermore, we showed as strong anisotropics in the microtremors are often observable in particular at high frequencies (&gt; 1 Hz). We have verified as microtremors can be difficult to considered as ergodic processes, and for this reason time averaging, also even over a long periods of time, cannot replace an appropriate azimuthal sampling.
Fabrication of Silver Vanadium Oxide and V2O5 Nanowires for Electrochromics (2008)

Silver vanadium oxide (SVO) and V2O5 nanowires have been hydrothermally synthesized. The as-made nanowires are over 30 microm long and 10-20 nm in diameter. The nanowires have a layered structure with a d-spacing of 1.07 nm. The nanowires can be fabricated into free-standing and flexible sheets by suction filtration. The electrical conductivity of the SVO nanowires is 0.5 S/cm, compared to 0.08 S/cm for the V2O5 nanowires. The Li ion diffusion coefficient in the SVO nanowires was 7 times higher than that in the V2O5 nanowires. An electrochromic device was fabricated from the SVO nanowires that displayed a color-switching time of 0.2 s from the bleached state (green) to the colored state (red-brown) and 60% transmittance contrast.
Signalling hypoxia by protein hydroxylation: Transcriptional architecture of the HIF response (2017)

Animal use a set of 2‐oxoglutarate dependent dioxygenases to signal cellular oxygen levels to the transcription factor, HIF, via the post‐translational hydroxylation of specific prolyl and asparaginyl residues. These hydroxylations promote the inactivation and proteolytic destruction of HIF and hence regulate a broad range of cellular and systemic responses to hypoxia. The involvement of this system in a many medically important physiological responses presents both an opportunity and challenge, particularly in defining how the system operates to generate co‐ordinated physiological responses, and in understanding how it might be manipulated therapeutically in specific medical conditions. Advances in the understanding of the pan‐genomic architecture of the HIF transcriptional response, will be described together with the implications of activating such extensive pathways in cancer, and mechanisms that modulate the oncogenic output of HIF pathway activation.
ChemInform Abstract: Preparation of Trifluoromethyl Lactol Derivatives via Base‐Initiated Cyclobutanol Ring‐Opening to a Laterally‐Lithiated Trifluoromethyl Ketone. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Practical applications of high-power ion beams (1992)

The results of experimental investigations on the practical applications of high-power ion beams are presented. These include the use of 200–300 keV, 50–250 A/cm2, 60 ns duration beams for modification of properties of metals and production of unique compounds in the surface layer of the target, pulse beam machining of implanted silicon hardening of cutting tools, reconditioning and cleaning machine parts
Role of theENPP1K121Q Polymorphism in Glucose Homeostasis (2008)

Homozygous carriers of the ENPP1 Q121 variant are characterized by an altered glucose homeostasis. Reduced early-phase insulin secretion and inefficient interplay between insulin secretion and sensitivity, which occur at early ages, are major determinants of this defect.
A methodology to determine the elastic properties of anisotropic rocks from a single uniaxial compression test (2019)

This paper introduces a new methodology to measure the elastic constants of transversely isotropic rocks from a single uniaxial compression test. We first give the mathematical proof that a uniaxial compression test provides only four independent strain equations. As a result, the exact determination of all five independent elastic constants from only one test is not possible. An approximate determination of the Young's moduli and the Poisson's ratios is however practical and efficient when adding the Saint–Venant relation as the fifth equation. Explicit formulae are then developed to calculate both secant and tangent definitions of the five elastic constants from a minimum of four strain measurements. The results of this new methodology applied on three granitic samples demonstrate a significant stress-induced nonlinear behavior, where the tangent moduli increase by a factor of three to four when the rock is loaded up to 20 MPa. The static elastic constants obtained from the uniaxial compression test are also found to be significantly smaller than the dynamic ones obtained from the ultrasonic measurements.
Solution Structural Studies of GTP:Adenosylcobinamide-Phosphateguanylyl Transferase (CobY) from Methanocaldococcus jannaschii (2015)

GTP:adenosylcobinamide-phosphate (AdoCbi-P) guanylyl transferase (CobY) is an enzyme that transfers the GMP moiety of GTP to AdoCbi yielding AdoCbi-GDP in the late steps of the assembly of Ado-cobamides in archaea. The failure of repeated attempts to crystallize ligand-free (apo) CobY prompted us to explore its 3D structure by solution NMR spectroscopy. As reported here, the solution structure has a mixed α/β fold consisting of seven β-strands and five α-helices, which is very similar to a Rossmann fold. Titration of apo-CobY with GTP resulted in large changes in amide proton chemical shifts that indicated major structural perturbations upon complex formation. However, the CobY:GTP complex as followed by 1H-15N HSQC spectra was found to be unstable over time: GTP hydrolyzed and the protein converted slowly to a species with an NMR spectrum similar to that of apo-CobY. The variant CobYG153D, whose GTP complex was studied by X-ray crystallography, yielded NMR spectra similar to those of wild-type CobY in both its apo- state and in complex with GTP. The CobYG153D:GTP complex was also found to be unstable over time.
The molecular and biochemical basis of cystic fibrosis (1987)

Review Article| March 01 1987 The molecular and biochemical basis of cystic fibrosis Margaret A. McPherson; Margaret A. McPherson 1Department of Medical Biochemistry, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, UK Search for other works by this author on: This Site PubMed Google Scholar Robert L. Dormer Robert L. Dormer 1Department of Medical Biochemistry, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, UK Search for other works by this author on: This Site PubMed Google Scholar Biosci Rep (1987) 7 (3): 167–185. https://doi.org/10.1007/BF01124787 Article history Received: April 15 1987 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation Margaret A. McPherson, Robert L. Dormer; The molecular and biochemical basis of cystic fibrosis. Biosci Rep 1 March 1987; 7 (3): 167–185. doi: https://doi.org/10.1007/BF01124787 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBioscience Reports Search Advanced Search Keywords: cystic fibrosis, exocrine, autonomic, cyclic AMP, calcium, chloride, epithelial © 1987 Plenum Publishing Corporation1987 Article PDF first page preview Close Modal You do not currently have access to this content.
Reactivation of telomerase in cancer (2016)

Activation of telomerase is a critical step in the development of about 85 % of human cancers. Levels of Tert, which encodes the reverse transcriptase subunit of telomerase, are limiting in normal somatic cells. Tert is subjected to transcriptional, post-transcriptional and epigenetic regulation, but the precise mechanism of how telomerase is re-activated in cancer cells is poorly understood. Reactivation of the Tert promoter involves multiple changes which evolve during cancer progression including mutations and chromosomal re-arrangements. Newly described non-coding mutations in the Tert promoter region of many cancer cells (19 %) in two key positions, C250T and C228T, have added another layer of complexity to telomerase reactivation. These mutations create novel consensus sequences for transcription factors which can enhance Tert expression. In this review, we will discuss gene structure and function of Tert and provide insights into the mechanisms of Tert reactivation in cancers, highlighting the contribution of recently identified Tert promoter mutations.
Error evaluation of hot-wire measurement in wall turbulence using a direct numerical simulation data base. (1990)

An error analysis for the hot-wire/film measurement in wall turbulence was performed using a direct numerical simulation (DNS) data base of the two-dimensional turbulent channel flow. Fairly complete models of single and dual sensor probes were considered. The effects of spatial resolution as well as that of the neglected velocity components were estimated quantitatively. It is concluded that sensor spacing has dominant effects on the measured values; near the wall, the wall-normal and spanwise turbulent intensities are overestimated considerably, while the streamwise one is slightly underestimated. These results are confirmed experimentally by physical measurement with an X-shaped fiber probe in a two-dimensional water channel.
Physicochemical principles of pharmacy [Book Review] (2012)

Review(s) of: Physicochemical principles of pharmacy, by Florence A.T., Attwood D., Pharmaceutical Press, 2011, 5th edn, paperback, 528 pp., ISBN 9780853699842, $100.
원저 : 조기분만 시 조직학적 융모양막염 유무에 따른 혈청 C-반응성 단백질, 태반 내 interleukin-6, 지 질과산화도 및 단백산화도 (2011)

목적: 조기분만 후 조직학적 융모양막염 유무에 따른 입원 시 임신부 혈액 백혈구, C-반응성 단백질과 태반 내 인터류킨-6 (interleukin-6, IL-6), 지질과산화도 및 단백산화도를 측정하여 비교하고 주산기 예후에 어떤 역할을 하는가 규명하고자 하였다. 연구방법: 양막파열이 없는 조기분만 임부 16명(조기 분만군), 만삭 전 조기양막파열 임부 29명(양막파열군)에서 입원 시 정맥혈과 분만 시 융모양막과 태반조직을 채취하였다. 양막하 공간에 중성구 침착 소견이 있었을 때 조직학적 융모양막염으로 진단하였다. 결과: 조직학적 융모양막염의 발생률은 양막파열군에서 조기 분만군보다 유의하게 높았다. 조직학적 융모양막염이 있는 군에서 없는 군보다 혈액 백혈구, 혈청 내 C-반응성 단백질 측정치와 태반 내 IL-6, 지질과산화도, 단백산화도 측정치가 모두 유의하게 높았다. 혈청 내 C-반응성 단백질 측정치와 태반 내 IL-6, 지질과산화도, 단백산화도 측정치는 조직학적 융모양막염이 있는 양막파열군에서 모두 유의하게 높았다. 혈청 내 C-반응성 단백질 측정치는 7일 이상 유지되었던 군에서 유의하게 낮았다. 양막파열군에서 7일 이상 유지될 수 있는지 판단하는 C-반응성 단백질의 측정치의 cutoff 값을 receiver operating characteristic curve를 이용하여 0.875 mg/dL의 결과를 얻었다. 조직학적 융모양막염이 있는 군에서 없는 군보다 신생아 호흡곤란증후군, 뇌실 내 출혈, 폐렴 등의 주산기 이환율이 높았다. 결론: 입원 시 임부 혈청 내 C-반응성 단백질 증가는 만삭 전 조기양막파열 산모의 잠복기를 예측하는 인자로 사용이 가능하다.
Miniaturized cavity-backed dual-polarized slot antenna (2012)

A novel compact dual-polarized slot antenna is proposed and implemented. It is a cavity-backed antenna realized by the substrate integrated waveguide (SIW) technology. The slot is meandered in order to miniaturize the antenna size and the SIW cavity is used to enhance the antenna gain and radiation efficiency. Good dual polarization performance is achieved and demonstrated by good isolation between the two ports and small envelope correlation efficient. The measured results are in good agreement with the simulated data. The proposed antenna exhibits a small size and is able to provide a good efficiency and polarization diversity performance.
Annulated lamellae in the ductus epididymidis of fetal and castrated adult rats (1968)

Abstract A consistent feature of epithelial cells lining the initial segment of the ductus epididymidis of rats bilaterally castrated for about three months is the presence of stacks of annulated lamellae. They were occasionally observed by two months following gonadectomy but were not evident in one‐month castrates nor in normal controls or unilaterally orchiectomized rats. Observation of epididymides from neonatal and fetal rats taken at daily intervals between the twelfth and twenty‐first day following conception demonstrated that small and inconspicuous annulated lamellae occurred normally during differentiation. They were observed on several occasions in widely scattered cells during the fifteenth day of gestation. In the epididymis, annulated membranes may form from the outer nuclear membrane by a process of budding. The annulated membrane complex is “destroyed” in long term castrates following the subcutaneous injection of testosterone proprionate.
Effect of various annealing environments on electrical and optical properties of indium tin oxide on polyethylene napthalate (2006)

The effect of different annealing ambients on the electrical and optical properties of indium tin oxide (ITO) on polyethylene napthalate (PEN) has been investigated. ITO layers of different carrier concentrations have been prepared by radio frequency sputtering followed by annealing in either 5% H2∕Ar, oxygen, or air at 150°C for 2h. The carrier concentration of the ITO films increased with heat treatment in the 5% H2∕Ar ambient. However, the carrier concentration of the ITO films decreased with heat treatment in oxygen and air atmospheres, respectively. Different annealing ambients affect the electrical properties of ITO/PEN samples by changing the oxygen vacancy in the ITO layer. Electrical mobilities were found to be affected by the carrier concentration. These experimental mobility values were in good agreement with those obtained from a theoretical ionized impurity scattering mechanism model. Optical transmittances of ∼86% were obtained for the ITO thin films and the optical band gap is about 3.15eV for all ITO films on PEN substrates.
Specific isolation of N‐terminal fragments from proteins and their high‐fidelity de novo sequencing (2007)

A new method to determine N-terminal amino acid sequences of multiple proteins at low pmol level by a parallel processing has been developed. The method contains the following five steps: (1) reduction, S-alkylation and guanidination for targeted proteins; (2) coupling with sulfosucccimidyl-2-(biotinamido)ethyl-1,3-dithiopropionate(sulfo-NHS-SS-biotin) to N(alpha)-amino groups of proteins; (3) digestion of the modified proteins by an appropriate protease; (4) specific isolation of N-terminal fragments of proteins by affinity capture using the biotin-avidin system; (5) de novo sequence analysis of peptides by MALDI-TOF-/MALDI-TOF-PSD mass spectrometry with effective utilization of the CAF (chemically assisted fragmentation) method.1 This method is also effective for N-terminal sequencing of each protein in a mixture of several proteins, and for sequencing components of a multiprotein complex. It is expected to become an essential proteomics tool for identifying proteins, especially when used in combination with a C-terminal sequencing method.
The Active Store providing Quality Enhanced Unified Messaging (1998)

A variety of concepts for service integration and corresponding service platforms emerged in the last two years which aim on the one hand for the interworking and integration of classical telecommunications and data communications services, such as telephony, voicemail, fax, e-mail, paging, etc. and on the other hand for universal service access from a variety of end user systems, including both fixed and mobile terminals. Unified Messaging as a branch of Personal Communication Support enhances control over reachability in telecommunication. Conversion technologies of communication media applying QoS evaluation allow to focus on the semantic of the information instead on carriage. An ODP system design and a CORBA-based prototype implementation provide the first step for a unified messaging system. This system can be integrated into other communication networks, e.g. as an IN service node or as a backbone service in an Extranet environment. This paper focuses on storage handling within the existing implementation and describes the quality enhancement in detail.
Tetrahedral framework nucleic acids as an advanced drug delivery system for oligonucleotide drugs (2020)

Nucleic acid therapy has played a promising role in the treatment of many diseases, such as cancer, infections, immune diseases, and neurodegenerative diseases. However, its application is still limited mainly because of poor cell-entry performance and low resistance to in vivo degradation. Tetrahedral framework nucleic acids (tFNAs) have shown potential in delivering low-molecular-weight drugs owing to their stability, biocompatibility, cell-entry performance, and flexible drug-loading ability. In particular, tFNAs can successfully deliver oligonucleotide drugs with improved effects and co-deliver oligonucleotide drugs with other drugs for synergistic effects. In this review, the recent progress on tFNA-based delivery of oligonucleotide drugs is outlined by single delivery systems—through sequence extension and complementation, and co-delivery systems—through multiple sequence extension, drug–DNA interactions, and specific binding. Furthermore, the current limitations and future developments of tFNA-based delivery of oligonucleotide drugs are discussed.
Gap Junctions Regulate Responses of Tendon Cells Ex Vivo to Mechanical Loading (1999)

Avian digital flexor tendons were used with a device to apply load ex vivo to study the effects on deoxyribonucleic acid and collagen synthesis when cell to cell communication is blocked. Flexor digitorum profundus tendons from the middle toe of 52-day-old White Leghorn chickens were excised and used as nonloaded controls, or clamped in the jaws of a displacement controlled tissue loading device and mechanically loaded for 3 days at a nominal 0.65% elongation at 1 Hz for 8 hours per day with 16 hours rest. Tendon samples were radiolabeled during the last 16 hours with 3H-thymidine to monitor deoxyribonucleic acid synthesis or with 3H-proline to radiolabel newly synthesized collagen. Cyclic loading of whole avian flexor tendons stimulated deoxyribonucleic acid and collagen synthesis, which could be blocked with octanol, a reversible gap junction blocker. Cells from human digital flexor tendon were used to populate a rectangular, three-dimensional, porous, polyester foam that could be deformed cyclically in vitro. Together, these results support the hypothesis that tendon cells must communicate to sustain growth and matrix expression and that an engineered three-dimensional construct can be used to study responses to mechanical load in vitro.
Abstract: Internal and external sources of electrons (1977)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation E. N. Sickafus; Abstract: Internal and external sources of electrons. J. Vac. Sci. Technol. 1 January 1977; 14 (1): 332. https://doi.org/10.1116/1.569202 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAVS: Science & Technology of Materials Interfaces and ProcessingJournal of Vacuum Science and Technology Search Advanced Search |Citation Search
The Assembly of Laminin-5 Subunits (1995)

Laminin-5 is a heterotrimer composed of alpha 3, beta 3, and gamma 2 chains, produced by keratinocytes and the human squamous cell carcinoma line (SCC-25), and is one of the candidate proteins for the genetic lesion in junctional epidermolysis bullosa. Two-dimensional SDS-polyacrylamide gel electrophoresis (first dimension, nonreducing conditions; second dimension, reducing conditions) revealed that the immunoprecipitated laminin-5 from a SCC-25 cell fraction consisted of alpha 3, beta 3, and gamma 2 monomers, a beta 3 gamma 2 heterodimer, and an alpha 3 beta 3 gamma 2 heterotrimer. The presence of the beta 3 gamma 2 heterodimer, but not heterodimers containing an alpha 3 chain and any of the other chains, was suggestive of assembly of laminin-5 proceeding from a beta 3 gamma 2 heterodimer to an alpha 3 beta 3 gamma 2 heterotrimer. We showed, by cotransfection experiments using full-length recombinant beta 3 and gamma 2 chains in a human cell line devoid of endogenous laminin-5, that stable heterodimers can be formed in the absence of alpha 3 chain expression. In the SCC-25 cell fraction, the alpha 3 monomer pool was the smallest of the monomers. Pulse-chase experiments using the cell fraction also indicated that the heterotrimer was assembled after a 10-min pulse and was nearly absent after a 24-h chase. These results are consistent with the synthesis of alpha 3 being limiting for heterotrimer assembly, with rapid association of the alpha 3 chain with beta 3 gamma 2 heterodimers to form complete heterotrimers. Treatment with tunicamycin reduced the size of each of the laminin-5 subunits, indicating that all chains are glycosylated, but that N-linked glycosylation is not necessary for chain assembly and secretion.
Halide Perovskite Photovoltaics (2020)

This chapter discusses halide perovskite materials for photovoltaic applications with regard to optical properties, along with the feasibility of bandgap tuning in ABX3 perovskites. The long diffusion length and carrier lifetime and the unique shallow defect physics are key factors to achieve outstanding photovoltaic performance of halide perovskites. Also addressed are determinant factors for the formation of perovskite structure and the exploration to achieve thermally stable halide perovskite. Formamidinium lead iodide and caesium lead iodide are more thermally stable but less structurally so compared to methylammonium lead iodide due to tolerance factor issue. At the end, this chapter explores strategies developed to stabilize these perovskite structures.
Are there risk factors for snowboard injuries? A case-control multicentre study of 559 snowboarders (2010)

Several risk factors and combinations exist, and different risk profiles were identified. Future research should be aimed at more precise identification of groups at risk and developing specific recommendations for each group-for example, a snow-weather conditions index at valley stations.