gebhart/patrepeval huggingface dataset:
Some Items of Interest to Process R&D Chemists and Engineers (2008)

ADVERTISEMENT RETURN TO ISSUEPREVHighlights from the ...Highlights from the LiteratureNEXTSome Items of Interest to Process R&D Chemists and EngineersMark McLaughlin, Silvina GarcíaRubio, Matthew Pfeiffer, Ulf Tilstam, Joseph Swaroop Mathen, Octavio Augusto Ceva Antunes, and Trevor LairdView Author Information Merck & Co. Inc.,Rahway, New Jersey 07065, U.S.A.E-mail: [email protected] Sapphire Therapeutics, Inc., Bridgewater, New Jersey 08807, U.S.A.E-mail: [email protected] Process R&D, PTD, Exelixis Inc.,South San Francisco, California 94080, U.S.A.E-mail: [email protected] CMC-Solutions, Belgium,E-mail: [email protected] Pharmacore Inc.,High Point, North Carolina 27265, U.S.A. E-mail: [email protected]; [email protected] Departamento de Quimica Inorganica,Instituto de Quimica, UFRJ, Cidade Universitaria,Rio de Janeiro, RJ 21949-900, Brazil,E-mail: [email protected]Cite this: Org. Process Res. Dev. 2008, 12, 3, 358–368Publication Date (Web):May 16, 2008Publication History Received7 April 2008Accepted7 April 2008Published online16 May 2008Published inissue 1 May 2008https://pubs.acs.org/doi/10.1021/op800087ehttps://doi.org/10.1021/op800087earticle-commentaryACS PublicationsCopyright © 2008 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views2029Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (299 KB) Get e-AlertscloseSUBJECTS:Anions,Catalysts,Chemical reactions,Reagents,Substitution reactions Get e-Alerts
Methods for displaying intracerebral vascular anatomy. (1997)

We are developing three-dimensional imaging methods to portray vascular anatomy better, including noise-free display of vessels extracted from 3-D data sets, tree-based display, and reconstruction of angiographic data (preliminary work has resulted in the successful reconstruction of aneurysms from angiographic data). Fast, interactive display permits real-time manipulation of viewing orientation.
New Front Side Access Approach for Low-k Dielectric/Cu Technologies in Plastic Package (2011)

Abstract This paper presents a new sample preparation process for front side access for die with organic dielectric layers that are encapsulated in plastic packages. The limitation of the standard failure analysis flow is firstly described, showing the damage caused by wet etching. Then, the decapsulation method combining laser ablation and plasma etching is presented. It is completed by the process optimization. The final process makes it possible to perform failure analysis on low-k/Cu technologies in plastic package either by the front side or by the backside of the die.
Metoclopramide (1998)

These results support the concept that the immunosuppression after hemorrhage may be mediated by hormones from the hypothalamic-pituitary-adrenal axis. Furthermore, MCP may be a useful adjuvant in the treatment of the trauma-hemorrhagic shock-induced immunosuppression.
Selective Pick-and-Place of Thin Film by Robotic Micromanipulation (2012)

Micro-engineering is increasingly interested in the use of thin films with thicknesses of less than 20nm. Before integrating these promising materials into complex Nano Electro Mechanical Systems (NEMS), their properties must be characterized. They must be transferred onto specific substrates for analysis. Current manipulation techniques are not suitable for the transfer of these thin films as they do not allow selection of the parts of the object that must be manipulated, and the quality of the sample is altered by traces of chemical residues. To perform the transfer of a selected thin film without modifying its properties, this paper presents a novel approach based on local gluing. This method has been validated by experiments performed on graphite films. Successful transfers of thin films of 4.2 × 4.7 µm2 to 70 × 12 µm2 with an estimated thickness of between 10 and 40 layers have been demonstrated. Limits of this technique are discussed.
<title>Mechanism of carrier photoexcitation in semiconducting polymers: the role of electron photoemission in photoconductivity measurements</title> (2002)

Ultrafast photoinduced absorption by infrared-active vibrational modes (IRAV) is used to detect charged photo- excitations (polarons) in solid films of conjugated luminescent polymers. Experiments, carried out in zero applied electric field, show that polarons are generated within 100 fs with quantum efficiencies of approximately 10%. The ultrafast photoinduced IRAV Absorption, the weak pump-wavelength dependence, and the linear dependence of charge density on pump intensity indicate that both charged polarons and neutral excitons are independently generated even at the earliest times. Measurements of the excitation profile of the transient and steady-state photoconductivity of poly(phenylene vinylene) and its soluble derivatives over a wide spectral range up to h(upsilon) = 6.2 eV indicate an apparent increase in the photoconductivity at h(upsilon) &gt; 3- 4 eV that arises from external currents generated by electron photoemission (PE). After quenching the PE by addition of CO<SUB>2</SUB>+SF<SUB>6</SUB> (90%:10%) into the sample chamber, the bulk photoconductivity is nearly independent of photon energy in all polymers studied, in a good agreement with the IRAV spectra. The single threshold for photoconductivity is spectrally close to the onset of (pi) - (pi) <SUP>*</SUP> absorption, behavior that is inconsistent with a large exciton binding energy.
High expression of heparin-binding EGF-like growth factor in rat hepatocarcinogenesis (1996)

Heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF) is a member of the EGF family and is highly expressed in hepatoma tissues but not in normal liver. However, it is unknown when HB-EGF is induced during hepatocarcinogenesis and what are the mechanisms underlying its high expression in hepatoma. To address this issue, the expression of HB-EGF was investigated during hepatocarcinogenesis in LEC (Long-Evans with a cinnamon-like coat color) rats, which spontaneously develop hepatitis and hepatoma. LEA (Long-Evans with an agouti coat color) rats were used as controls. Furthermore, the induction of HB-EGF mRNA by various agents was investigated in a rat hepatoma cell line and hepatocytes in primary culture. Expression of HB-EGF mRNA in the liver was very low at the stage of acute and chronic hepatitis and markedly increased at the stage of hepatoma in LEC rats. Non-involved tissues adjacent to hepatoma showed low expression of HB-EGF mRNA. Immunochemical studies revealed positive staining in hepatoma tissues. Induction of HB-EGF mRNA by several growth factors was observed in a hepatoma cell line but not in normal hepatocytes. Our results suggest that HB-EGF is associated with the early progression steps of hepatoma.
Chloroquine or hydroxychloroquine for prevention and treatment of COVID-19 (2021)

HCQ for people infected with COVID-19 has little or no effect on the risk of death and probably no effect on progression to mechanical ventilation. Adverse events are tripled compared to placebo, but very few serious adverse events were found. No further trials of hydroxychloroquine or chloroquine for treatment should be carried out. These results make it less likely that the drug is effective in protecting people from infection, although this is not excluded entirely. It is probably sensible to complete trials examining prevention of infection, and ensure these are carried out to a high standard to provide unambiguous results.
Risk for Behçet’s disease gauged via high-density lipoprotein cholesterol: a nationwide population-based study in Korea (2022)

Behçet's disease (BD) is a chronic inflammatory disease. Low levels of plasma high-density lipoprotein cholesterol (HDL-C) are associated with Crohn's disease, another chronic inflammatory disease. However, the effects of low HDL-C levels on BD are unclear. We investigated the effects of HDL-C levels, and variability therein, on the risk for BD. We used the Korean National Health Insurance System database to identify 5,587,754 adults without a history of BD who underwent ≥ 3 medical examinations between 2010 and 2013. Mean HDL-C levels at each visit were used to calculate variability independent of the mean (VIM) and the coefficient of variation (CV). There were 676 new cases of BD (0.012%). The risk for BD was increased in participants with highly variable and low mean HDL-C levels. In a multivariate-adjusted model, the hazard ratios (95% confidence intervals) for BD incidence were 1.335 (1.058-1.684) in a high mean/high VIM group, 1.527 (1.211-1.925) in a low mean/low VIM group, and 2.096 (1.67-2.63) in a low mean/high VIM group compared to a high mean/low VIM group. Low mean HDL-C levels, and high variability therein, are independent risk factors for BD.
Data from Functional Precision Medicine Provides Clinical Benefit in Advanced Aggressive Hematologic Cancers and Identifies Exceptional Responders (2023)

&lt;div&gt;Abstract&lt;p&gt;Personalized medicine aims to match the right drug with the right patient by using specific features of the individual patient's tumor. However, current strategies of personalized therapy matching provide treatment opportunities for less than 10% of patients with cancer. A promising method may be drug profiling of patient biopsy specimens with single-cell resolution to directly quantify drug effects. We prospectively tested an image-based single-cell functional precision medicine (scFPM) approach to guide treatments in 143 patients with advanced aggressive hematologic cancers. Fifty-six patients (39%) were treated according to scFPM results. At a median follow-up of 23.9 months, 30 patients (54%) demonstrated a clinical benefit of more than 1.3-fold enhanced progression-free survival compared with their previous therapy. Twelve patients (40% of responders) experienced exceptional responses lasting three times longer than expected for their respective disease. We conclude that therapy matching by scFPM is clinically feasible and effective in advanced aggressive hematologic cancers.&lt;/p&gt;Significance:&lt;p&gt;This is the first precision medicine trial using a functional assay to instruct n-of-one therapies in oncology. It illustrates that for patients lacking standard therapies, high-content assay-based scFPM can have a significant value in clinical therapy guidance based on functional dependencies of each patient's cancer.&lt;/p&gt;&lt;p&gt;&lt;i&gt;&lt;a href="https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-21-1498" target="_blank"&gt;See related commentary by Letai, p. 290&lt;/a&gt;.&lt;/i&gt;&lt;/p&gt;&lt;p&gt;&lt;i&gt;&lt;a href="https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-12-2-ITI" target="_blank"&gt;This article is highlighted in the In This Issue feature, p. 275&lt;/a&gt;&lt;/i&gt;&lt;/p&gt;&lt;/div&gt;
Biologically Active Natural Products:  Pharmaceuticals Edited by Stephen J. Cutler and Horace G. Cutler (Mercer University, Atlanta, GA). CRC Press, New York, NY. 2000. xvi + 277 pp. 17.5 × 25 cm. $99.95. ISBN 0-8493-1887-4. (2000)

ADVERTISEMENT RETURN TO ISSUEPREVBook ReviewNEXTBiologically Active Natural Products: Pharmaceuticals Edited by Stephen J. Cutler and Horace G. Cutler (Mercer University, Atlanta, GA). CRC Press, New York, NY. 2000. xvi + 277 pp. 17.5 × 25 cm. $99.95. ISBN 0-8493-1887-4.James B. GloerView Author Information Department of Chemistry University of Iowa Iowa City, Iowa 52242-1294Cite this: J. Nat. Prod. 2000, 63, 6, 891Publication Date (Web):May 10, 2000Publication History Published online10 May 2000Published inissue 1 June 2000https://pubs.acs.org/doi/10.1021/np9907329https://doi.org/10.1021/np9907329book-reviewACS PublicationsCopyright © 2000 American Chemical Society and American Society of PharmacognosyRequest reuse permissionsArticle Views169Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Antimicrobial agents,Detoxification,Electrophiles,Metabolism,Pharmaceuticals Get e-Alerts
Measurements of Biomagnetism with a Magnetic Shield for a High-Tc Superconductor (1994)

We developed a helmet-sized superconducting magnetic shield for a high-T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</sub> Bi-Pb-Sr-Ca-Cu-O superconductor. The shield is 32 cm in diameter, 60 cm in depth, and 2.5 cm thick. It was experimentally confirmed that the container can reduce a weak magnetic field by -100 dB or to 1/100,000. The shielding effect of the superconducting container does not decrease even at frequencies as low as 0.2 Hz. Using equipment consisting of a superconducting container, a cryostat to keep the container at liquid nitrogen temperature, and an rf SQUID gradiometer, we successfully detected the magnetic fields of a human brain. We detected somatosensory magnetic fields by stimulating the tibial nerves of the patient with current pulses.
CRE‐Enhancer DNA Decoy (2003)

Enhancer DNA decoy oligonucleotides (ODNs) inhibit transcription by competing for transcription factors. A decoy ODN composed of the cAMP response element (CRE) inhibits CRE-directed gene transcription and tumor growth without affecting normal cell growth. We used DNA microarrays to analyze the global gene expression in tumors exposed to the CRE-decoy ODN. The CRE decoy upregulated the AP-2beta transcription factor gene in tumors but not in the livers of host animals. The upregulated expression of AP-2beta was clustered with other upregulated genes involved in development and cell differentiation. Concomitantly, another cluster of genes involved in cell proliferation and transformation was downregulated. The observed alterations indicate that CRE-directed transcription favors tumor growth. Evidence presented here suggests that the CRE-decoy ODN may provide a target-based genetic tool for treating cancer, viral diseases, and other diseases in which CRE-directed transcription is abnormally used.
K-means assisted soft decision of PAM4 to mitigate level nonlinearity and level-dependent noise for VCSEL-based 100-Gbps 100-m MMF optical interconnection (2019)

A likelihood ratio estimation method based on K-means clustering is proposed and experimentally demonstrated for soft decision of PAM4 to mitigate the level nonlinearity and level-dependent noise. Commercial-VCSEL-based 100-Gbps 100-m MMF optical transmission is achieved.
Half-life of 67Cu (2021)

Abstract The half-life of 67 Cu was determined through serial gamma-ray spectrometry measurements of the dominant gamma emission (E γ : 184.6 keV; branching ratio: 48.7%) produced following β - decay. Data were collected consecutively for 1000 s per measurement, with a total of 3063 measurements over the duration of 36 days. The incidence rate for the 184.6 keV gamma-ray was determined from the spectral peak area and duration of each measurement. This rate was then corrected to account for detector dead-time, radioactive decay during each acquisition and drift in the computer clock in comparison to NIST nuclear clock. Least-squares regression analysis was performed to determine the half-life of 67 Cu. The result was 61.761 ± 0.004 h, which is the highest precision measurement to date, and marks a 24-fold precision improvement over the current Nuclear Data Sheets value.
Impact of mental stressor on conditioned pain modulation (2012)

[6] Nilsen KB, Christiansen SE, Holmen LB, Sand T. The effect of a mental stressor on Conditioned pain modulation (CPM) is the phenomenon hrough which the conditioning stimulus affects the test stimuus [1]. Such phenomenon is previously termed “Diffuse noxious nhibitory controls (DNIC)” [2], which is known as “pain inhibits ain phenomenon (inhibitory CPM)”. It has been reported that the CPM effect is impaired in, e.g. usculoskeletal pain patients [3]. Moreover, there is an indication hat the attenuated CPM might be relevant to stress [4]. Although tresswould reduce pain [5], the effect ofmental stressor on CPM is nclear to date. The elucidation of the relationship betweenmental tressor and CPM may play a key role to reveal such a complicated ndogenous pain inhibitory phenomenon in chronic pain patients. The study of Kristian B. Nilsen and co-workers in theis issue f the Scandinavian Journal of Pain [6] investigated the effect of a ental stressor on CPM on young healthy human subjects. Conitioning stimulus was induced with tourniquet. The test stimuli ereheatpain threshold, supra-thresholdheatpain level, andpresure pain threshold. Stressful task was to subtract 7 from 1000 uccessively for five minutes. The applied methodology for test timuli and the conditioning stimulus is common to test CPM [7]. In ddition, a well-established stressful test was employed. Measureents of CPM effect were performed at baseline, after a stressful ask, and after a non-stressful task. The CPMeffectswere calculated s thedifferencebetween the threshold/level after the conditioning timulus and the baseline threshold/level. The results showed that the CPM effect was significantly higher fter the non-stressful task compared to the stressful task. This is he first study to systematically investigate the effect of mental tressor on CPM.
Mobile Test Unit for in Situ Measurement of Fan Performance (1990)

A mobile fan testing unit was developed for in situ measurement of total airflow delivered by agricultural fans. A supply fan driven by a diesel engine through a hydrostatic drive was used to deliver air through a perforated plate into a canvas duct with the test fan at the opposite end. Balance was achieved by increasing the speed of the supply fan until it delivered the same flow into the duct as was being removed by the test fan. Pressure drop was measured across a calibrated perforated plate to determine total flow. Six peanut dryer fans were tested. Calibrated resistance plates were installed at the plenum ports to simulate the flow resistance of trailers loaded with peanuts. Flow was determined by first measuring the pressure drop across each plate, and then summing to get total flow. Agreement between perforated plate total flow and resistance plate total flow ranged from -0.6 to 3.45%, which is within the error bound for the measurements.
Beitrag zur Frage nach den thermodynamischen Eigenschaften und dem Aufbau flüssiger Legierungen des Systems Indium-Thallium (1977)

Article Beitrag zur Frage nach den thermodynamischen Eigenschaften und dem Aufbau flüssiger Legierungen des Systems Indium-Thallium was published on April 1, 1977 in the journal International Journal of Materials Research (volume 68, issue 4).
Rational Design of a Two‐Photon Fluorogenic Probe for Visualizing Monoamine Oxidase A Activity in Human Glioma Tissues (2020)

Abstract Monoamine oxidases have two functionally distinct but structurally similar isoforms (MAO‐A and MAO‐B). The ability to differentiate them by using fluorescence detection/imaging technology is of significant biological relevance, but highly challenging with available chemical tools. Herein, we report the first MAO‐A‐specific two‐photon fluorogenic probe ( F1 ), capable of selective imaging of endogenous MAO‐A enzymatic activities from a variety of biological samples, including MAO‐A‐expressing neuronal SY‐SY5Y cells, the brain of tumor‐bearing mice and human Glioma tissues by using two‐photon fluorescence microscopy (TPFM) with minimal cytotoxicity.
Sutureless laparoscopic rectopexy for procidentia (1992)

Procedures for treating rectal prolapse may constitute some of the best applications for colorectal laparoscopic techniques. Although the condition is benign, rectal prolapse is often debilitating and frequently progressive in terms of functional limitations. Moreover, many patients are elderly, medically unfit, or both. A technique that afforded relief of prolapse and of incontinence by laparoscopic rectal sacropexy, performed without sutures, using a newly designed laparoscopic sacral tacker and laparoscopic staples, is described. Indications, contraindications, technical details, and surgical implications are discussed. Laparoscopic pelvic suspension procedures are presented as realistic and appropriate objectives for colon and rectal surgeons.
Undersea Fiber Cable Technology (1982)

Compared with the conventional coaxial undersea cable systems, an optical fiber undersea cable system has a great technical and economical advantage. It is also suitable for digital transmission. In this paper, the optical fiber undersea cable technology (including optical fiber cables and repeaters), which is now in the research and development stage in several countries, is reviewed.
Transformer core vibration measurements by means of laser scanning vibrometer (2016)

A major part of the transformer noise and vibrations comes from the deformation of the magnetoelastic material of the transformer core. In this work the vibrations of a test transformer core are measured by means of a laser scanning vibrometer. Due to the presence of the higher harmonics in the grid voltage, in addition to a purely sinusoidal magnetisation of the core the presence of a third harmonic is also studied. The vibrations of three points along the core leg are measured. Moreover, for a better
illustration of the deformation a 3-dimensional surface scan of the core leg is also performed. The results show that the core deforms more in the corners than in the middle of the leg. The influence of the third harmonic of the magnetisation on the core deformation is also more significant in the corners of the leg. The core deformation shape under a sinusoidal magnetisation with a higher harmonic is more wavy and fluctuating than that under a purely sinusoidal magnetisation.
Self-Assembly and Cross-linking of FePt Nanoparticles at Planar and Colloidal Liquid−Liquid Interfaces (2008)

Terpyridine thiol functionalized FePt and Au NPs were self-assembled and cross-linked at the liquid-liquid interfaces using Fe(II) metal ion. Complexation of terpyridine with Fe(II) metal ion leads to NP network and affords stable membranes and colloidal shells at the liquid-liquid interfaces.