gebhart/patrepeval huggingface dataset:
Personalizing Similar Product Recommendations in Fashion E-commerce (2018)

In fashion e-commerce platforms, product discovery is one of the key components of a good user experience. There are numerous ways using which people find the products they desire. Similar product recommendations is one of the popular modes using which users find products that resonate with their intent. Generally these recommendations are not personalized to a specific user. Traditionally, collaborative filtering based approaches have been popular in the literature for recommending non-personalized products given a query product. Also, there has been focus on personalizing the product listing for a given user. In this paper, we marry these approaches so that users will be recommended with personalized similar products. Our experimental results on a large fashion e-commerce platform (Myntra) show that we can improve the key metrics by applying personalization on similar product recommendations.
Identification of the most effective chemotherapy in recurrent ovarian cancer using the spheroid model (2014)

Background and aims: Most ovarian cancer patients suffer relapse despite multimodal treatment. According to international guidelines a variety of drug options exist. The aim of the present study was the identification of the most effective chemotherapy for the individual ovarian cancer patient using the spheroid model. Treatment response pattern was correlated with the cellular and molecular characteristics of the individual tumor.
Regulation of medical devices involving software in Australia: an overview (2001)

The Therapeutic Goods Administration (TGA) regulates the supply of therapeutic goods in Australia --- including medical devices. Many medical devices are not programmable, electronic, or even electrical. However more devices are becoming programmable, and existing medical device software is becoming more complex.Currently in Australia, certain types of medical devices are subjected to extensive pre-market documentary evaluation by the TGA. However most devices have less scrutiny.It is proposed that medical device regulation in Australia will harmonise with the European Union Medical Device Directive. It is thereby hoped to: enhance requirements for many devices that are currently subject to few or no controls; reduce duplication for devices previously assessed by an overseas regulatory body; and to place increased emphasis on manufacturer quality and risk management systems and on post-market surveillance.The intention is to address the safety of medical device software in its environmental context, and as a part of the device as a whole.
Oophorectomy (2015)

An oophorectomy involves removing one or both ovaries depending on the indication for the surgery. Removing one ovary does not usually affect sexual function, but removing both ovaries may affect sexual function. Long‐term health risks after oophorectomy at younger age (e.g., before age 50 years) include higher rates of cardiovascular disease and stroke.
Design and Implementation of IPv6 Segment Routing (2016)

Segment Routing is the modern variant of source routing being standardised by the Internet Engineering Task Force. It enables routers and endhosts to better control the path followed by their packets in the network. We first describe the utilisation of the IPv6 Segment Routing extension header and motivate the main design choices. We then explain how we have modified the Linux kernel to support this new header and evaluate its performance. Finally, we demonstrate our implementation on two very different use cases : parental control and firewall load balancing.
Oral testosterone undecanoate (Andriol®) supplement therapy improves the quality of life for men with testosterone deficiency (2003)

In a single-blind, placebo-controlled study, the effects of a 3-month oral administration of 160 mg/day testosterone undecanoate (Andriol) on the quality of life of men with testosterone deficiency were evaluated. The subjects included ten men with primary hypogonadism and 29 with andropause with sexual dysfunction as the most common problem. The changes in subjective symptoms were evaluated by the PNUH QoL scoring system and the St. Louis University Questionnaire for androgen deficiency in aging males (ADAM). Digital rectal examination (DRE) was performed and serum testosterone, prostate-specific antigen (PSA) and liver profile were monitored. Testosterone undecanoate treatment (n = 33) significantly improved sexual dysfunction and symptom scores of metabolic, cardiopulmonary, musculoskeletal and gastrointestinal functions compared to baseline and to placebo (n = 6). ADAM score also significantly improved after 3 months of treatment. Serum testosterone was significantly increased compared to pretreatment levels only in the testosterone undecanoate group. In the placebo group, no significant changes compared to baseline were found for testosterone levels and QoL questionnaires. No abnormal findings were detected on DRE or laboratory findings in either group. Adverse events, such as gastrointestinal problems and fatigue, were mild and self-limiting. It is concluded that androgen supplement therapy with oral testosterone undecanoate (Andriol) restores the quality of life through improvement of general body functions in men with testosterone deficiency.
CTRP11 contributes modestly to systemic metabolism and energy balance (2022)

C1q/TNF-related proteins (CTRP1-15) constitute a conserved group of secreted proteins of the C1q family with diverse functions. In vitro studies have shown that CTRP11/C1QL4 can inhibit adipogenesis, antagonize myoblast fusion, and promote testosterone synthesis and secretion. Whether CTRP11 is required for these processes in vivo remains unknown. Here, we show that knockout (KO) mice lacking CTRP11 have normal skeletal muscle mass and function, and testosterone level, suggesting that CTRP11 is dispensable for skeletal muscle development and testosterone production. We focused our analysis on whether this nutrient-responsive secreted protein plays a role in controlling sugar and fat metabolism. At baseline when mice are fed a standard chow, CTRP11 deficiency affects metabolic parameters in a sexually dimorphic manner. Only Ctrp11-KO female mice have significantly higher fasting serum ketones and reduced physical activity. In the refeeding phase following food withdrawal, Ctrp11-KO female mice have reduced food intake and increased metabolic rate and energy expenditure, highlighting CTRP11's role in fasting-refeeding response. When challenged with a high-fat diet to induce obesity and metabolic dysfunction, CTRP11 deficiency modestly exacerbates obesity-induced glucose intolerance, with more pronounced effects seen in Ctrp11-KO male mice. Switching to a low-fat diet after obesity induction results in greater fat loss in wild type relative to KO male mice, suggesting impaired response to obesity reversal and reduced metabolic flexibility in the absence of CTRP11. Collectively, our data provide genetic evidence for novel sex-dependent metabolic regulation by CTRP11, but note the overall modest contribution of CTRP11 to systemic energy homeostasis.
SP-157: Recent Developments In Lateral Force Transfer In Buildings (1995)

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Update on Cardiovascular Safety of PPARgamma Agonists and Relevance to Medicinal Chemistry and Clinical Pharmacology (2012)

Peroxisome proliferator-activator receptors (PPARs) are now known as members of the nuclear hormonereceptor superfamily of ligand-activated transcription factors that regulate gene expression in response to nutritional and physiological stimuli. PPARγ plays a crucial role in glucose homeostasis and it is involved in the regulation of lipid metabolism and adipocyte differentiation and function. From all the PAARγ ligands, the thiazolidindiones (TZDs) are of most clinical importance. Rosiglitazone and pioglitazone have been largely used so far in the clinical practice. They provide similar effects on glycemic control, as well as a range of similar adverse effects, such as weight gain, fluid retention, and increased risk of hearth failure, which seem to be PPARγ mediated. Interestingly, they differ on their effect on lipid and cardiovascular safety profile, indicating a PPARγ-independent mechanism. Indeed, rosiglitazone was recently withdrawn in Europe and its use has been restricted in USA as a consequence of increased risk of cardiovascular events in type 2 diabetic patients. This review is focused on the cardiovascular effects of rosiglitazone and pioglitazone as representative members of PPARγ ligands, because they were widely evaluated in many clinical trials and experimental studies and data obtained from these studies are relevant from medicinal chemistry and clinical pharmacology point of view. Finally, an overview on the development of selective PPARγ modulators and/or dual PPARα/γ agonists will be given. These new approaches might provide anti-hyperglycemic efficacy without the associated undesirable side-effects. However, further experimental and clinical studies evaluating the theoretical benefit and safety of this therapeutic strategy are needed.
Milk-Fat-Globule-Membrane-Enriched Dairy Milk Compared with a Soy-Lecithin-Enriched Beverage Did Not Adversely Affect Endotoxemia or Biomarkers of Gut Barrier Function and Cardiometabolic Risk in Adults with Metabolic Syndrome: A Randomized Controlled Crossover Trial (2023)

Full-fat dairy milk may protect against cardiometabolic disorders, due to the milk fat globule membrane (MFGM), through anti-inflammatory and gut-health-promoting activities. We hypothesized that a MFGM-enriched milk beverage (MEB) would alleviate metabolic endotoxemia in metabolic syndrome (MetS) persons by improving gut barrier function and glucose tolerance. In a randomized crossover trial, MetS persons consumed for two-week period a controlled diet with MEB (2.3 g/d milk phospholipids) or a comparator beverage (COMP) formulated with soy phospholipid and palm/coconut oil. They then provided fasting blood and completed a high-fat/high-carbohydrate test meal challenge for evaluating postprandial metabolism and intestinal permeability. Participants had no adverse effects and achieved high compliance, and there were no between-trial differences in dietary intakes. Compared with COMP, fasting endotoxin, glucose, incretins, and triglyceride were unaffected by MEB. The meal challenge increased postprandial endotoxin, triglyceride, and incretins, but were unaffected by MEB. Insulin sensitivity; fecal calprotectin, myeloperoxidase, and short-chain fatty acids; and small intestinal and colonic permeability were also unaffected by MEB. This short-term study demonstrates that controlled administration of MEB in MetS persons does not affect gut barrier function, glucose tolerance, and other cardiometabolic health biomarkers, which contradicts observational evidence that full-fat milk heightens cardiometabolic risk. Registered at ClinicalTrials.gov (NCT03860584).
Distinct Properties of Hexameric but Functionally Conserved Mycobacterium tuberculosis Transcription-Repair Coupling Factor (2011)

Transcription coupled nucleotide excision repair (TC-NER) is involved in correcting UV-induced damage and other road-blocks encountered in the transcribed strand. Mutation frequency decline (Mfd) is a transcription repair coupling factor, involved in repair of template strand during transcription. Mfd from M. tuberculosis (MtbMfd) is 1234 amino-acids long harboring characteristic modules for different activities. Mtbmfd complemented Escherichia coli mfd (Ecomfd) deficient strain, enhanced survival of UV irradiated cells and increased the road-block repression in vivo. The protein exhibited ATPase activity, which was stimulated ∼1.5-fold in the presence of DNA. While the C-terminal domain (CTD) comprising amino acids 630 to 1234 showed ∼2-fold elevated ATPase activity than MtbMfd, the N-terminal domain (NTD) containing the first 433 amino acid residues was able to bind ATP but deficient in hydrolysis. Overexpression of NTD of MtbMfd led to growth defect and hypersensitivity to UV light. Deletion of 184 amino acids from the C-terminal end of MtbMfd (MfdΔC) increased the ATPase activity by ∼10-fold and correspondingly exhibited efficient translocation along DNA as compared to the MtbMfd and CTD. Surprisingly, MtbMfd was found to be distributed in monomer and hexamer forms both in vivo and in vitro and the monomer showed increased susceptibility to proteases compared to the hexamer. MfdΔC, on the other hand, was predominantly monomeric in solution implicating the extreme C-terminal region in oligomerization of the protein. Thus, although the MtbMfd resembles EcoMfd in many of its reaction characteristics, some of its hitherto unknown distinct properties hint at its species specific role in mycobacteria during transcription-coupled repair.
Aero-Acoustic Microphone with Layer-Transferred Single-Crystal Silicon Piezoresistors (2009)

International audience
Cholesterol: Its Regulation and Role in Central Nervous System Disorders (2012)

Cholesterol is a major constituent of the human brain, and the brain is the most cholesterol-rich organ. Numerous lipoprotein receptors and apolipoproteins are expressed in the brain. Cholesterol is tightly regulated between the major brain cells and is essential for normal brain development. The metabolism of brain cholesterol differs markedly from that of other tissues. Brain cholesterol is primarily derived by de novo synthesis and the blood brain barrier prevents the uptake of lipoprotein cholesterol from the circulation. Defects in cholesterol metabolism lead to structural and functional central nervous system diseases such as Smith-Lemli-Opitz syndrome, Niemann-Pick type C disease, and Alzheimer's disease. These diseases affect different metabolic pathways (cholesterol biosynthesis, lipid transport and lipoprotein assembly, apolipoproteins, lipoprotein receptors, and signaling molecules). We review the metabolic pathways of cholesterol in the CNS and its cell-specific and microdomain-specific interaction with other pathways such as the amyloid precursor protein and discuss potential treatment strategies as well as the effects of the widespread use of LDL cholesterol-lowering drugs on brain functions.
Application of a semiconductor tip to capacitance microscopy (1998)

A semiconductor tip has been applied to the scanning capacitance microscopy (SCM). Local electrostatic fields are measured through depletion of carriers at the tip end. A Si microcantilever with the sharp end is employed. This SCM technique has been used in a capacitance observation of a dielectric/electrode sample. Potentiometry using this technique is demonstrated in an experiment of charge injection recording on a polymer film.
Microstructure of Reaction-Bonded Silicon Carbide including Molybdenum Disiliside (2007)

Residual silicon in the reaction-bonded silicon carbide (RBSiC) can be replaced by refractory MoSi2 by using Si-Mo alloy as infiltrants instead of pure Si. Transmission electron microscopy of these materials clarified the following results. The MoSi2 existed in the SiC grain boundaries and many fine grains of SiC were found in the MoSi2 phase. The carbon particles were thought to be dissolved into the Si melt including Mo and reprecipitated as SiC particles in the solution-reprecipitation mechanism. The Mo concentration in the Si-Mo melt increased with the reprecipitation of SiC particles, and the MoSi2 was precipitated in the grain boundaries. The presence of the fine SiC particles in the MoSi2 phase suggests that the carbon have a fairly strong interaction with silicon in the melt and diffuse not as isolated atoms, but as C-Si pairs.
An Efficient Pipeline for Distant Person Detection and Identification in 4K Video using GPUs (2020)

The gradual advent of machine learning has been assisting to shift the field of computer vision from statistical methods to deep neural networks. These networks should be able to process high resolution video streams coming from the HD camera sources in real time. However, due to the fixed network size and to maintain the processing speed, high resolution frames need to be resized and down-sampled before feeding into the networks resulting in loss of feature information, hampering recognition accuracy. This motivated us to propose a methodology which focuses on creating and processing the active region of interests in the foreground image through an active region generator (ARG) module, eliminating the need to traverse the entire frame and down-sample the resolution before feeding it to the neural network. This resulted in saving 25x more image feature information, whilst maintaining a given person detection accuracy of 92 % mAP for longer distance up to 30~35 metre executing in real time w.r.t it's classical counterpart based on singleshot detector model. Besides, our proposed pipeline architecture utilizing multi-core TESLA GPU increases the execution throughput by a factor of 3X verified in NVIDIA DGX system.
Principal Axes Estimation Using the Vibration Modes of Physics-Based Deformable Models (2008)

This paper addresses the issue of accurate, effective, computationally efficient, fast, and fully automated 2-D object orientation and scaling factor estimation. The object orientation is calculated using object principal axes estimation. The approach relies on the object's frequency-based features. The frequency-based features used by the proposed technique are extracted by a 2-D physics-based deformable model that parameterizes the objects shape. The method was evaluated on synthetic and real images. The experimental results demonstrate the accuracy of the method, both in orientation and the scaling estimations.
Model Predictive Control of Coke Oven Gas Collector Pressure (2014)

In the light of the existing control problems in coke oven gas collector pressure systems, a model predictive control (MPC) method based on subspace identification of the gas collector pressure control system is presented. Through the analysis of a number of measurable variables, the main decision variables which affect gas collector pressure including the controllable input variables and the measurable disturbance can be obtained. The proposed method employs a subspace technique for the identification of the coke oven gas collector pressure control system, and simulates the disturbance of coal charging by a pulse signal with a certain width. A two-layer structure optimal control system of coke oven gas collector pressure is established and thus steady-state optimization and dynamic control can be realized, respectively. With consideration of the influence of measurable disturbance, we calculate the steady-state target through the degrees of freedom of the system, and then constrained MPC dynamic optimization is carried out. The algorithm has been successfully applied in the JN-8-type coke oven gas collector pressure control system of an iron and steel group, and has achieved good results.
Motor correlates of phantom limb pain (2017)

Following amputation, individuals ubiquitously report experiencing lingering sensations of their missing limb. While phantom sensations can be innocuous, they are often manifested as painful. Phantom limb pain (PLP) is notorious for being difficult to monitor and treat. A major challenge in PLP management is the difficulty in assessing PLP symptoms, given the physical absence of the affected body part. Here, we offer a means of quantifying chronic PLP by harnessing the known ability of amputees to voluntarily move their phantom limbs. Upper-limb amputees suffering from chronic PLP performed a simple finger-tapping task with their phantom hand. We confirm that amputees suffering from worse chronic PLP had worse motor control over their phantom hand. We further demonstrate that task performance was consistent over weeks and did not relate to transient PLP or non-painful phantom sensations. Finally, we explore the neural basis of these behavioural correlates of PLP. Using neuroimaging, we reveal that slower phantom hand movements were coupled with stronger activity in the primary sensorimotor phantom hand cortex, previously shown to associate with chronic PLP. By demonstrating a specific link between phantom hand motor control and chronic PLP, our findings open up new avenues for PLP management and improvement of existing PLP treatments.
Small leucine rich repeat proteoglycans (SLRPs) in the human sclera: identification of abundant levels of PRELP. (2006)

These results suggest that several SLRP proteoglycans are expressed in the human sclera and provide the first description of the PRELP protein in the human sclera. The relative abundance of PRELP mRNA and protein in the human sclera, and the observed age-related variation in scleral PRELP expression suggests that PRELP may play a critical role in regulating the biomechanical properties of scleral extracellular matrix.
Measuring and Managing Blood Pressure in a Primary Care Setting: A Pragmatic Implementation Study (2018)

Our clinic-based AOBP/HBPM program detected white-coat BP elevation in one third of enrolled patients, facilitated control of home BP, and was acceptable to staff and patients. We identified barriers to be addressed to ensure sustainability.
Pulmonary Function after Treatment for Childhood Cancer. A Report from the St. Jude Lifetime Cohort Study (SJLIFE) (2016)

Impaired pulmonary function in adult survivors of childhood cancer is associated with decreased physical function. These patients may benefit from interventions designed to preserve and/or improve pulmonary function.
A gaze interactive textual smartwatch interface (2015)

Mobile gaze interaction is challenged by inherent motor noise. We examined the gaze tracking accuracy and precision of twelve subjects wearing a gaze tracker on their wrist while standing and walking. Results suggest that it will be possible to detect whether people are glancing the watch, but not where on the screen they are looking. To counter the motor noise we present a word-by-word textual UI that shows temporary command options to be executed by gaze-strokes. Twenty-seven participants conducted a simulated smartwatch task and were able to reliably perform commands that would adjust the speed of word presentation or make regressions. We discuss future design and usage options for a textual smartwatch gaze interface.
Complete thermal lens control of a 10-100 Hz terawatt system (2003)

Summary form only given. We demonstrate a novel 10-100-Hz terawatt source where the thermal distortion is not anymore an issue while varying the repetition rate. The problem of thermal distortion has been already demonstrated for high repetition rates laser as 1-kHz. One recent example for controlling this effect is a thermal eigenmode amplifier where the thermal lens is used to transform a classic multipass amplifier to a real eigenmode cavity. This method has shown very good results in a several mJ, ultrashort Ti:sapphire amplifier laser chain. An amplifier crystal cooled to 125-K has been also demonstrated for a kHz, 0.2-TW laser system. For intermediate repetition rate (10-100 Hz) the thermal aberration is less critical due to the relative high diameter of the pump beam on the amplifier. Nevertheless, it has to be taken into account to preserve a constant high beam quality during amplification.