gebhart/patrepeval huggingface dataset:
Three-dimensional bioprinting using self-assembling scalable scaffold-free “tissue strands” as a new bioink (2016)

Recent advances in bioprinting have granted tissue engineers the ability to assemble biomaterials, cells, and signaling molecules into anatomically relevant functional tissues or organ parts. Scaffold-free fabrication has recently attracted a great deal of interest due to the ability to recapitulate tissue biology by using self-assembly, which mimics the embryonic development process. Despite several attempts, bioprinting of scale-up tissues at clinically-relevant dimensions with closely recapitulated tissue biology and functionality is still a major roadblock. Here, we fabricate and engineer scaffold-free scalable tissue strands as a novel bioink material for robotic-assisted bioprinting technologies. Compare to 400 μm-thick tissue spheroids bioprinted in a liquid delivery medium into confining molds, near 8 cm-long tissue strands with rapid fusion and self-assemble capabilities are bioprinted in solid form for the first time without any need for a scaffold or a mold support or a liquid delivery medium, and facilitated native-like scale-up tissues. The prominent approach has been verified using cartilage strands as building units to bioprint articular cartilage tissue.
Partial Differential Equation-Constrained Optimization Framework for Viscoelastic Material Design. (2017)

Abstract not provided.
Intravitreal Longevity of Three Perfluorocarbon Gases (1980)

Three gases, perfluoromethane, perfluoroethane, and perfluoropropane (CF4, C2F6, and C3 F8, respectively) were studied for their possible value as intravitreal tamponades in retinal surgery. The gases expand and have intraocular longevities that increase with the length of the carbon chain. A 0.4-cc injection of CF4, remained in the eye six days, twice as long as an equivalent amount of air; C2F6 remained 16 days, more than four times as long as air; and C3F8 remained 28 days, nine times as long as air and four times as long as sulfur hexafluoride.
LIGHT Hits the Liver (2007)

An inflammatory molecule on the surface of certain immune cells increases the concentration in blood of fats associated with atherosclerosis.
Effects of Folic Acid Therapy on the New-Onset Proteinuria in Chinese Hypertensive Patients (2017)

URL: http://www.ClinicalTrials.gov. Unique identifier: NCT00794885.
Effect of heat treatment on the functional properties of linseed meal (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of heat treatment on the functional properties of linseed mealK. T. Madhusudhan and Narendra SinghCite this: J. Agric. Food Chem. 1985, 33, 6, 1222–1226Publication Date (Print):November 1, 1985Publication History Published online1 May 2002Published inissue 1 November 1985https://pubs.acs.org/doi/10.1021/jf00066a052https://doi.org/10.1021/jf00066a052research-articleACS PublicationsRequest reuse permissionsArticle Views268Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Admission control with flow aggregation for QoS provisioning in software-defined network (2014)

Software Defined Network (SDN) may significantly enhance network and service management by enabling separated control and data planes. The centralized OpenFlow controller with a global vision of network states offers a promising approach to realizing flow-based admission control for supporting Quality of Service (QoS) provisioning in SDN. However, per-flow process brings in challenges to scalability of OpenFlow-based SDN. Flow aggregation has been explored as an effective method to address this issue. In this paper, we investigate admission control with flow aggregation for QoS provisioning in SDN. Specifically we propose a model for admission control with flow aggregation and develop the analysis techniques for determining the required amounts of bandwidth and buffer space at OpenFlow-enabled switches for meeting performance requirements in delay and packet loss. Network calculus is applied in our modeling and analysis; which makes our method applicable to general OpenFlow-based SDNs with various implementations. Numerical experiment results are also provided to evaluate effectiveness of the developed modeling and analysis techniques.
Monopulse Doppler radar for vehicle applications (2002)

This paper describes an efficient, forward looking, radar system that can be used for vehicle applications including collision warning, collision avoidance and adaptive or intelligent cruise control. A Doppler radar system is described that uses a monopulse antenna scheme to track multiple targets and generate range, range rate and azimuth angle output data for each target. The system requires less than 2 MHz of bandwidth and can be designed to operate at any microwave or millimeter-wave frequency. The transmitted power is less than 2 milliwatts and the system can track targets to ranges in excess of 125 meters. The radar system uses frequency modulated continuous wave (FMCW) radar transmission with frequency shift keying (FSK) for range measurements to minimize bandwidth requirements. The advantages and disadvantages of a Doppler radar system with FSK modulation are presented. A block diagram of the radar system is included and the theory of operation is described in the text. The Doppler radar system described employs digital signal processing (DSP) and fast Fourier transforms (FFT) to identify, separate and track individual targets in the frequency domain. The system produces range, range rate and azimuth angle as independent data values even though they are mathematically related. The Doppler radar system described in this paper measures range, range rate and azimuth angle independently and simultaneously.
Effects of a GnRH analogue on human smooth muscle cells cultured from normal myometrial and from uterine leiomyomal tissues (1997)

Leiomyomas are tumours of uterine smooth muscle tissue that are oestrogen and progesterone dependent. When explants of these tumours were grown in culture, the proliferating tissue formed characteristic ball-like aggregates (BLA), rather than the usual hill and valley (HV) pattern of growth of normal myometrial tissue in culture. Immunocytochemical staining with fluorescein isothiocyanate (FITC)-labelled gonadotrophin-releasing hormone (GnRH) revealed that both myometrial and leiomyomal cells have membrane receptors for this hypothalamic releasing hormone. Furthermore, polymerase chain reactions (PCR) with primer sets that were specific for GnRH receptor mRNA, as well as GnRH mRNA, showed that transcripts for both of these nucleic acids are present in myometrial and leiomyomal tissues. The treatment of cultured explants of leiomyomal tissue with a GnRH analogue (buserelin, HOE766) diminished the formation of BLA, but this synthetic hormone had only a moderate effect on the HV topography of normal myometrial tissue. A colorimetric assay indicated that GnRHa inhibited cell proliferation in leiomyomal tissue in a dose-dependent manner. Western blotting, to detect the expression of G1 phase cell cycle-related gene products, showed that cyclin E and p33cdk2 formation in leiomyomas were inhibited by high concentrations of GnRHa. In conclusion, GnRHa might suppress leiomyomal growth by interfering with the expression of cell cycle factors.
Performance Analysis of a Class of GSC Receivers Over Nonidentical Weibull Fading Channels (2005)

The performance of a class of generalized-selection combining (GSC) receivers operating over independent but nonidentically distributed Weibull fading channels is studied. We consider the case where the two branches with the largest instantaneous signal-to-noise ratio (SNR), from a total of L available, GSC(2, L) are selected. By introducing a novel property for the product of moments of ordered Weibull random variables, convenient closed form expressions for the moments of the GSC(2,L) output SNR are derived. Using these expressions, important performance criteria, such as average output SNR and amount of fading, are obtained in closed form. Furthermore, employing the Pade/spl acute/ approximants theory and the moment-generating function approach, outage and bit-error rate performance are studied. An attempt is also made to identify the equivalency between the Weibull and the Rice fading channel, which is typically used to model the mobile satellite channel. We present various numerical performance evaluation results for different modulation formats and channel conditions. These results are complemented by equivalent computer simulated results which validate the accuracy of the proposed analysis.
Response-Guided Peginterferon Therapy in Hepatitis B E Antigen-Positive Chronic Hepatitis B Using Serum Hepatitis B Surface Antigen Levels (2013)

HBsAg is a strong predictor of response to PEG-IFN in HBeAg-positive CHB. HBV genotype-specific stopping-rules may be considered at week 12, but treatment discontinuation is indicated in all patients with HBsAg >20,000 IU/mL at week 24, irrespective of HBV genotype.
Radioiodinated 5-iodothienyl-2-substituted long chain fatty acids for myocardial imaging (1984)

Thienyl-2-alkyl derivatives undergo facile iodination regiospecifically at the 5-position of the thiophene ring and are alternatives to iodophenyl agents. /sup 125/I-labeled 2-(17-oxoheptadecanoly)-5-iodothiophene (VIIIa) and /sup 125/I-labeled 2-(13-oxotridecanoyl)-5-iodothiophene (VIIIb) were prepared as model agents. The substrate was 2-(17-oxoheptadecanoyl)thiophene (VIa), in which the thiophene ring was attached to the terminal position of heptadecanoic acid. (VIa) was prepared by Friedel-Crafts condensation of 16-iodohexadecanoyl chloride, with thiophene followed by -I + CN/sup -/ ..-->.. -CN; Wolff-Kishner reduction; -CN + OH/sup -/ ..-->.. -COOH (VI). Regiospecific rho-(bis-(trifluoroacety 1)) thallation of (VIa), followed by treatment with KI gave 2-(17-oxoheptadecanoyl)-5-iodothiophene (VIIIa). Compound VIIIb was prepared in the same manner. Compounds Ia, b-VIIIa,b, were analyzed by TLC, IR, MS, NMR, and CandH. I-125-labeled (VIIIa) and (VIIIb) were prepared in the same manner. I-125 (VIIIb) showed high myocardial uptake in rats (4/group). Iodothienyl fatty acids may represent alternatives to iodophenyl substituted fatty acids for myocardial imaging.
Iron (2001)

[7439-89-6] Fe (MW 55.85) InChI = 1S/Fe InChIKey = XEEYBQQBJWHFJM-UHFFFAOYSA-N (efficient catalyst for a wide variety of organic transformations) Physical Data: mp 1535 °C; d 7.860 g cm−3. Solubility: insol water, alkalis, alcohols, ethers; sol acid (attacked or dissolved). Form Supplied in: chip, foil, filings, powder, wire. Analysis of Reagent Purity: atomic absorption methods can be used. Handling, Storage, and Precautions: moisture sensitive.
III.—THE DOCTRINE OF CONNOTATION AND DENOTATION (1945)

Journal Article III.—THE DOCTRINE OF CONNOTATION AND DENOTATION Get access WINSTON H. F. BARNES WINSTON H. F. BARNES Search for other works by this author on: Oxford Academic Google Scholar Mind, Volume LIV, Issue 215, July 1945, Pages 254–263, https://doi.org/10.1093/mind/LIV.215.254 Published: 01 July 1945
Poly (Amphiphilic Pyrr0Le)-PPO Electrodes for Organic-Phase Enzymatic Assay (1995)

Abstract The utility of amphiphilic pyrrole monomers to elaborate stable organic-phase polymers containing enzyme is described. Four amphiphilic pyrrole monomers differing in the size of their ammonium groups were applied to the immobilization of a preadsorbed enzyme-monomer coating. The peiformances of the different biosensors towards the detection of catechol, 4-tert-butylcatechol and phenol have been examined in either anhydrous or wet chloroform solutions.
ChemInform Abstract: Synthetic Uses of Thioesters of Trifluoromethylated Acids. Part 2. Reactions with Alkenes. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Rapid stimulation of phospholipid metabolism in bovine lymphocytes by tumor-promoting phorbol esters. (1978)

12- O -Tetradecanoylphorbol-13-acetate (TPA), a highly active tumor-promoting agent and lymphocyte comitogen, accelerates the incorporation of [ methyl -3H]choline chloride ([3H-Me]choline) into the phospholipids of bovine lymphocytes.

Chromatographic analysis of the phospholipids from lymphocytes exposed to 10-8 m TPA for varying intervals in the presence of [3H-Me]choline reveals a lag period of about 20 min, after which the rate of labeling of phosphatidylcholine, lysophosphatidylcholine, and sphingomyelin are all enhanced. Structure-activity studies show that the ability of phorbol diesters to accelerate [3H-Me]choline incorporation runs parallel to their potency as lymphocyte comitogens and as tumor promoters. The response to TPA is insensitive to the inhibition of RNA and protein synthesis by actinomycin D and cycloheximide, respectively, and is also insensitive to the inhibition of membrane movement by cytochalasin B. Retinoic acid, an antagonist of the tumor-promoting and comitogenic actions of TPA, also blocks the acceleration of [3H-Me]choline incorporation into phospholipids by TPA. These observations suggest that the bovine lymphocyte system may be useful for studies of the molecular mechanisms of action of tumor-promoting phorbol esters and their retinoid antagonists.
Axially Lumped Versus Axially Distributed Modeling of Liquid-to-Gas Cross-Flow Heat Exchanger Transients (1994)

Abstract Thermal transients of single-row finned-tube serpentine liquid-to-gas cross-flow heat exchangers utilizing single phase fluids are examined numerically in the temperature-time domain. Two modeling approaches are examined with the aim of contrasting levels of modeling sophistication for this specific heat exchanger application. One model is axially lumped (cases with more than one lump are examined), and the second model is axially distributed. The lumped model is solved using a 4th order Runge-Kutta integration scheme, and the distributed model is solved using an explicit upwind differencing scheme. Single lump representation is found to be undesirable, while multi-lump representation provides adequate comparison with the distributed model. Computation times become an issue for the lumped model if multiple lumps are solved using the 4th order Runge-Kutta scheme.
Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis (2020)

Malignant cells exhibit aerobic glycolysis (the Warburg effect) and become dependent on de novo lipogenesis, which sustains rapid proliferation and resistance to cellular stress. The nuclear receptor liver-X-receptor (LXR) directly regulates expression of key glycolytic and lipogenic genes. To disrupt these oncogenic metabolism pathways, we designed an LXR inverse agonist SR9243 that induces LXR-corepressor interaction. In cancer cells, SR9243 significantly inhibited the Warburg effect and lipogenesis by reducing glycolytic and lipogenic gene expression. SR9243 induced apoptosis in tumors without inducing weight loss, hepatotoxicity, or inflammation. Our results suggest that LXR inverse agonists may be an effective cancer treatment approach.
Base-Induced Mechanistic Variation in Palladium-Catalyzed Carbonylation of Aryl Iodides (2010)

A mechanism, which is distinct from the traditional one when sodium alkoxide was used instead of tertiary amines, was proposed for the alkoxycarbonylation of aryl iodides. The catalytic cycle was composed of oxidative addition, subsequent ArPdOR formation, CO insertion to Pd-OR, and final reductive elimination of ArPdCOOR. The kinetic simultaneity of the formation of deiodinated side product from the aryl iodide and aldehyde from corresponding alcohol provided strong evidence for the existence of ArPdOR species. The observation of thioether, as the other competitive product in palladium catalyzed thiocarbonylation of aryl iodides and sodium alkylthiolate, also indicate the possibility of metathesis between ArPdI and sodium alkylthiolate. Preliminary kinetic studies revealed that neither oxidative addition nor reductive elimination was rate limiting. DFT calculation displayed preference for CO insertion into Pd-OR bond. The advantage of this novel mechanism had been demonstrated in the facile alkoxycarbonylation and thiocarbonylation. The ethoxycarbonylation of aryl iodides under room temperature and balloon pressure of CO in the presence of EtONa were examined, and good to high yields were obtained; the t-butoxycarbonylation reactions in the presence of t-BuONa were achieved, and the alkylthiocarbonylation (including the t-butylthiocarbonylation) of aryl iodides in the presence of sodium alkylthiolate were also investigated.
Design of Power Stage and Controller for DC-DC Converter Systems Using PSPICE (2006)

A complete set of SPICE-compatible design equations for design buck converter system is developed in this paper. In this approach, the power stage and controller design equations are programmed in PSPICE. For this purpose, an option available in PSPICE called Analog Behavioral Modeling (ABM) is used. In this manner, the parameter of power stage and the component values of the error amplifier can be easily obtained by means of PSPICE bias point analysis. The obtained parameters can be passed to other circuit models to perform frequency response and transient analysis. The methodology of development is presented in details. A design example is included to demonstrate the effectiveness of the proposed approach in designing DC-DC converter systems.
Electrostatics, proton sensor, and networks governing the gating transition in GLIC, a proton-gated pentameric ion channel (2018)

The pentameric ligand-gated ion channel (pLGIC) from <i>Gloeobacter violaceus</i> (GLIC) has provided insightful structure-function views on the permeation process and the allosteric regulation of the pLGICs family. However, GLIC is activated by pH instead of a neurotransmitter and a clear picture for the gating transition driven by protons is still lacking. We used an electrostatics-based (finite difference Poisson-Boltzmann/Debye-Hückel) method to predict the acidities of all aspartic and glutamic residues in GLIC, both in its active and closed-channel states. Those residues with a predicted pK<sub>a</sub> close to the experimental pH<sub>50</sub> were individually replaced by alanine and the resulting variant receptors were titrated by ATR/FTIR spectroscopy. E35, located in front of loop F far away from the orthosteric site, appears as the key proton sensor with a measured individual pK<sub>a</sub> at 5.8. In the GLIC open conformation, E35 is connected through a water-mediated hydrogen-bond network first to the highly conserved electrostatic triad R192-D122-D32 and then to Y197-Y119-K248, both located at the extracellular domain-transmembrane domain interface. The second triad controls a cluster of hydrophobic side chains from the M2-M3 loop that is remodeled during the gating transition. We solved 12 crystal structures of GLIC mutants, 6 of them being trapped in an agonist-bound but nonconductive conformation. Combined with previous data, this reveals two branches of a continuous network originating from E35 that reach, independently, the middle transmembrane region of two adjacent subunits. We conclude that GLIC's gating proceeds by making use of loop F, already known as an allosteric site in other pLGICs, instead of the classic orthosteric site.
Effect of High-frequency Ventilation on the Development of Alveolar Edema in Premature Monkeys at Risk for Hyaline Membrane Disease (1991)

High-frequency oscillatory ventilation (HFOV) permits adequate gas exchange but avoids the large phasic pressure-volume excursions of conventional mechanical ventilation (CMV); such avoidance may reduce the lung injury associated with hyaline membrane disease (HMD). We hypothesized that premature monkeys ventilated from birth with HFOV would have reduced lung injury compared to those assigned to CMV. Macaca nemestrina were delivered at 134 days (80% of term gestation) and ventilated from the first breath with either HFOV (n = 10) or CMV (n = 10). The mean airway pressure (Paw) was kept at 15 cm H2O pressure in HFOV animals; in CMV animals Paw was increased from 8 cm H2O at 2 h to 13 cm H2O at 6 h to prevent hypoxemia. At the conclusion of the 6-h experiment the HFOV animals had better oxygenation (p less than 0.05) and less evidence of HMD by chest radiograph (p less than 0.05). At 6 h of age a piece of the right middle lung lobe was removed, divided, and placed in fixatives for light and transmission electron microscopy. The lungs were subsequently inflated to 30 cm H2O pressure, and the right lower lobe was rapidly frozen in situ for morphometric studies. The proportion of peripheral lung tissue occupied by clear alveoli was greater in HFOV animals (66.3 +/- 14.8%) than in those assigned to CMV (44.2 +/- 16.9%, p less than 0.01); less alveolar debris and fluid was present in the HFOV animals (12.7 +/- 9.9%) compared with CMV animals (27.1 +/- 12.5%, p less than 0.02).(ABSTRACT TRUNCATED AT 250 WORDS)
Multiscale analysis of gas absorption in liquids (2013)

info:eu-repo/semantics/nonPublished
Protocol Data Parts Inclusion in a Formal Passive Testing Approach (2011)

Commonly, two main classes of formal testing techniques are applied to check the conformance of protocols and software: active and passive testing (monitoring) techniques. Because of many industrial constraints such as the necessity to achieve implementation black box testing, passive testing techniques become highly relevant in several cases. Besides, most of the passive testing techniques only consider control portions of exchanged packets and ignores data parts. However, since systems become more complex, testing for data constraints and relations between packets is now essential. In this paper we propose a novel approach for defining data oriented invariants and show how they can be tested in a trace set by using logic programming. Experimental results on SIP protocol traces are provided.