gebhart/patrepeval huggingface dataset:
Structural characterization and cage-condensation reactions of the coupled-cage borane 1:2'-[B5H8]2: new routes to higher single-cage boranes and carboranes (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructural characterization and cage-condensation reactions of the coupled-cage borane 1:2'-[B5H8]2: new routes to higher single-cage boranes and carboranesJames J. Briguglio, Patrick J. Carroll, Edward W. Corcoran Jr., and Larry G. SneddonCite this: Inorg. Chem. 1986, 25, 26, 4618–4622Publication Date (Print):December 1, 1986Publication History Published online1 May 2002Published inissue 1 December 1986https://doi.org/10.1021/ic00246a005RIGHTS & PERMISSIONSArticle Views111Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (607 KB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Bank green lending and credit risk: an empirical analysis of China's Green Credit Policy (2022)

Abstract This study empirically investigates the relationship between banks' green lending and their credit risk, and how Chinese green finance regulations contribute to the solvency of individual banks and the resilience of the financial system. Analysing a sample of 41 Chinese banks from 2007 to 2018, we find that the association between a bank's (relative) green lending as a proportion of its overall loan portfolio, and its credit risk, depends critically on the size and structure of state ownership. While the implementation of China's Green Credit Policy reduces credit risk for the major state‐controlled banks, it increases credit risk for the city and regional commercial banks. This performance difference appears largely due to information and expertise asymmetries, with the city and regional commercial banks having less access to information and expertise necessary to evaluate the credit risk of green lending. Understanding this phenomenon can help policymakers tailor green finance policies according to banks' characteristics. It also suggests that mechanisms and platforms for the city/regional commercial banks to learn from the major state‐controlled banks could be beneficial.
Inhibitors of SecA as Potential Antimicrobial Agents (2022)

Protein translocation is essential for bacterial survival and the most important translocation mechanism in bacteria is the secretion (Sec) pathway. Thus targeting Sec pathway is a promising strategy for developing novel antibacterial therapeutics. We report the design, syntheses, mechanistic studies and structure-activity relationship studies using HQSAR and 3-D QSAR Topomer CoMFA analyses of 4-oxo-5-cyano thiouracil derivatives. In summary, introduction of polar group such as ?N3 and linker groups such as ?CH2-O- enhanced the potency as well as logP and logS several fold. We also report the discovery, optimization and structure-activity relationship study of 1,2,4-triazole containing pyrimidines as novel, highly potent antimicrobial agents. A number of inhibitors have been found to inhibit microbial growth at high nanomolar concentrations.
Tumor Dosimetry and Response for 153Sm-Ethylenediamine Tetramethylene Phosphonic Acid Therapy of High-Risk Osteosarcoma (2012)

The variations in tumor density, mass, and shape seen in these tumors did not affect the mean tumor AD estimation significantly. The tumor EUD was approximately 2- and 3-fold lower than the mean AD for low- and high-dose therapy, respectively. A dose-response relationship was observed for transient tumor volume shrinkage.
Exploring Binding and Effector Functions of Natural Human Antibodies Using Synthetic Immunomodulators (2013)

The ability to profile the prevalence and functional activity of endogenous antibodies is of vast clinical and diagnostic importance. Serum antibodies are an important class of biomarkers and are also crucial elements of immune responses elicited by natural disease-causing agents as well as vaccines. In particular, materials for manipulating and/or enhancing immune responses toward disease-causing cells or viruses have exhibited significant promise for therapeutic applications. Antibody-recruiting molecules (ARMs), bifunctional organic molecules that redirect endogenous antibodies to pathological targets, thereby increasing their recognition and clearance by the immune system, have proven particularly interesting. Notably, although ARMs capable of hijacking antibodies against oligosaccharides and electron-poor aromatics have proven efficacious, systematic comparisons of the prevalence and effectiveness of natural anti-hapten antibody populations have not appeared in the literature. Herein we report head-to-head comparisons of three chemically simple antigens, which are known ligands for endogenous antibodies. Thus, we have chemically synthesized bifunctional molecules containing 2,4-dinitrophenyl (DNP), phosphorylcholine (PC), and rhamnose. We have then used a combination of ELISA, flow cytometry, and cell-viability assays to compare these antigens in terms of their abilities both to recruit natural antibody from human serum and also to direct serum-dependent cytotoxicity against target cells. These studies have revealed rhamnose to be the most efficacious of the synthetic antigens examined. Furthermore, analysis of 122 individual serum samples has afforded comprehensive insights into population-wide prevalence and isotype distributions of distinct anti-hapten antibody populations. In addition to providing a general platform for comparing and studying anti-hapten antibodies, these studies serve as a useful starting point for the optimization of antibody-recruiting molecules and other synthetic strategies for modulating human immunity.
Molecular pathology of human prion disease (2010)

Human prion diseases are associated with a range of clinical presentations and are classified by both clinicopathological syndrome and aetiology with sub-classification according to molecular criteria. Considerable experimental evidence suggests that phenotypic diversity in human prion disease relates in significant part to the existence of distinct human prion strains encoded by abnormal PrP isoforms with differing physicochemical properties. To date, however, the conformational repertoire of pathological isoforms of wild-type human PrP and the various forms of mutant human PrP has not been fully defined. Efforts to produce a unified international classification of human prion disease are still ongoing. The ability of genetic background to influence prion strain selection together with knowledge of numerous other factors that may influence clinical and neuropathological presentation strongly emphasises the requirement to identify distinct human prion strains in appropriate transgenic models, where host genetic variability and other modifiers of phenotype are removed. Defining how many human prion strains exist allied with transgenic modelling of potentially zoonotic prion strains will inform on how many human infections may have an animal origin. Understanding these relationships will have direct translation to protecting public health.
IgG antibody responses are preferential compared to IgM for use as serological markers for detecting recent exposure to Plasmodium vivax infection (2020)

Abstract To achieve malaria elimination, new tools are required to explicitly target Plasmodium vivax . Recently, a novel panel of P. vivax proteins were identified and validated as serological markers for detecting recent exposure to P. vivax within the last 9 months. In order to improve the sensitivity and specificity of these markers, IgM in addition to IgG antibody responses were assessed to a down-selected panel of 20 P. vivax proteins. IgM was tested using archival plasma samples from observational cohort studies conducted in malaria-endemic regions of Thailand and Brazil. IgM responses to these proteins generally had poorer classification performance than IgG.
Silylcyclopropanes by Selective [1,4]-Wittig Rearrangement of 4-Silyl-5,6-dihydropyrans (2021)

4-Silyl-5,6-dihydropyrans undergo remarkably selective [1,4]-Wittig rearrangements to give silylcyclopropanes in good yields. The selectivity is independent of the silyl group, but it is influenced by the electronic character of the migrating center. Electron-rich and electron-neutral (hetero)aryl groups and aliphatic substituents at the migrating center lead to exclusive [1,4]-migration, whereas electron-deficient aryl groups predominantly afford [1,2]-Wittig products.
A chemical screen based on an interruption of zebrafish gastrulation identifies the HTR2C inhibitor Pizotifen as a suppressor of EMT-mediated metastasis (2021)

Abstract Metastasis is responsible for approximately 90% of cancer-associated mortality but few models exist that allow for rapid and effective screening of anti-metastasis drugs. Current mouse models of metastasis are too expensive and time consuming to use for rapid and high-throughput screening. Therefore, we created a unique screening concept utilizing conserved mechanisms between zebrafish gastrulation and cancer metastasis for identification of potential anti-metastatic drugs. We hypothesized that small chemicals that interrupt zebrafish gastrulation might also suppress metastatic progression of cancer cells and developed a phenotype-based chemical screen to test the hypothesis. The screen used epiboly, the first morphogenetic movement in gastrulation, as a marker and enabled 100 chemicals to be tested in five hours. The screen tested 1280 FDA-approved drugs and identified Pizotifen, an antagonist for serotonin receptor 2C (HTR2C) as an epiboly-interrupting drug. Pharmacologic and genetic inhibition of HTR2C suppressed metastatic progression in a mouse model. Blocking HTR2C with Pizotifen restored epithelial properties to metastatic cells through inhibition of Wnt-signaling. In contrast, HTR2C induced epithelial to mesenchymal transition (EMT) through activation of Wnt-signaling and promoted metastatic dissemination of human cancer cells in a zebrafish xenotransplantation model. Taken together, our concept offers a novel platform for discovery of anti-metastasis drugs.
Energy Disaggregation via Learning Powerlets and Sparse Coding (2015)

In this paper, we consider the problem of energy disaggregation, i.e., decomposing a whole home electricity signal into its component appliances. We propose a new supervised algorithm, which in the learning stage, automatically extracts signature consumption patterns of each device by modeling the device as a mixture of dynamical systems. In order to extract signature consumption patterns of a device corresponding to its different modes of operation, we define appropriate dissimilarities between energy snippets of the device and use them in a subset selection scheme, which we generalize to deal with time-series data. We then form a dictionary that consists of extracted power signatures across all devices. We cast the disaggregation problem as an optimization over a representation in the learned dictionary and incorporate several novel priors such as device-sparsity, knowledge about devices that do or do not work together as well as temporal consistency of the disaggregated solution. Real experiments on a publicly available energy dataset demonstrate that our proposed algorithm achieves promising results for energy disaggregation.
A 10Gb/s CMOS Clock and Data Recovery Circuit with Frequency Detection (2009)

A 10 Gb/s phase-locked clock and data recovery circuit incorporates a multiphase LC oscillator and a half-rate phase/frequency detector with automatic data retiming. In 0.18 /spl mu/m CMOS technology, the circuit exhibits 1.43 GHz capture range and 0.8 ps rms jitter with length 2/sup 23/ PRBS. The power dissipation is 91 mW from a 1.8 V supply.
Hidden interplay of current-induced spin and orbital torques in bulk Fe3GeTe2 (2022)

Low crystal symmetry of magnetic van der Waals materials naturally promotes spin-orbital complexity unachievable in common magnetic materials used for spin-orbit torque switching. Here, using first-principles methods, we demonstrate that an interplay of spin and orbital degrees of freedom has a profound impact on spin-orbit torques in the prototypical van der Waals ferromagnet Fe 3 GeTe 2 . While we show that bulk Fe 3 GeTe 2 hosts strong "hidden" current-induced torques harvested by each of its layers, we uncover that their origin alternates between the conventional spin flux torque and the so-called orbital torque as the magnetization direction is varied. A drastic difference in the behavior of the two types of torques results in a nontrivial evolution of switching properties with doping. Our findings promote the design of nonequilibrium orbital properties as the guiding mechanism for crafting the properties of spin-orbit torques in layered van der Waals materials.
Algorithm 763: INTERVAL_ARITHMETIC (1996)

Interval arithmetic is useful in automatically verified computations , that is, in computations in which the algorithm itself rigorously proves that the answer must lie within certain bounds. In addition to rigor, interval arithmetic also provides a simple and sometimes sharp method of bounding ranges of functions for global optimization and other tasks. Convenient use of interval arithmetic requires an interval data type in the programming language. Although various packages supply such a data type, previous ones are machine specific, obsolete, and unsupported, for languages other than Fortran, or commercial. The Fortran 90 module INTERVAL_ARITHMETIC provides a portable interval data type in Fortran 90. This data type is based on two double-precision real Fortran storage units. Module INTERVAL_ARTHMETIC uses the Fortran 77 library INTLIB (ACM TOMS Algorithm 737) as a supporting library. The module has been employed extensively in the author's own research.
Sex-Dependent Association of Vitamin D With Insulin Resistance in Humans (2021)

Vitamin D was inversely and independently associated with insulin resistance only in women with vitamin D deficiency. Based on our data, we suggest that in particular vitamin D deficient women might benefit from vitamin D substitution by improving insulin resistance. This, however, needs to be proven in adequately designed double-blind placebo-controlled clinical studies.
Optimizations of the Spatial Decomposition Method for Binaural Reproduction (2021)

The spatial decomposition method (SDM) can be used to parameterize and reproduce a sound field based on measured multichannel room impulse responses (RIRs). In this paper we propose optimizations of SDM to address the following questions and issues that have recently emerged in the development of the method: (a) accuracy in direction-of-arrival (DOA) estimation with open microphone arrays utilizing time differences of arrival as well as with B-format arrays using pseudo-intensity vectors; (b) optimal array size and temporal processing window size for broadband DOA estimation based on open microphone arrays; (c) spatial and spectral distortion of single events caused by unstable DOA estimation; and (d) spectral whitening of late reverberation as a consequence of rapidly varying DOA estimates. Through simulations we analyze DOA estimation accuracy (a) and explore processing parameters (b) in search of optimal settings. To overcome the unnatural DOA spread (c), we introduce spatial quantization of the DOA as a post-processing step at the expense of spatial distortion for successive reflections. To address the spectral whitening (d), we propose an equalization approach specifically designed for rendering SDM data directly to binaural signals with a spatially dense HRTF dataset. Finally, through perceptual experiments, we evaluate the proposed equalization and investigate the consequences of quantizing the spatial information of SDM auralizations by directly comparing binaural renderings with real loudspeakers. The proposed improvements for binaural rendering are released in an open source repository.
Efficiency and Cavitation Effects of Hydroturbine Venting (1991)

Volkart and Bohac et al. have summarized much of the past work on aeration of hydroturbine releases to improve downstream water quality. Conventional alternatives for increasing dissolved oxygen levels in hydropower releases include selective withdrawal intakes, weirs, surface pumps, diffusers, and compressors. Alabama Power Company pioneered the use of draft tube baffles to pull air directly into hydroturbines and increase aeration over a wider range of operating conditions (Buck et al., 1980). At its Norris Hydro Plant, the Tennessee Valley Authority (TVA) has installed hub baffles which create localized low pressure areas and aspirate air into the turbine discharge. This paper describes tests conducted to evaluate the effect of these hub baffles on hydroturbine efficiency and cavitation.
Mechanisms of camptothecin resistance in yeast DNA topoisomerase I mutants. (1993)

The anti-cancer drug camptothecin targets eukaryotic DNA topoisomerase I by trapping the covalent complex formed between the catalytically active enzyme and DNA. Saccharomyces cerevisiae cells expressing yeast DNA topoisomerase I mutant top1 vac (I725R, N726A) or top1N726L, in which the amino acid residues N terminus to the active site tyrosine Tyr-727 were changed as indicated, were found to be camptothecin-resistant even though the mutant proteins expressed in Escherichia coli were previously shown to be active. Assays of enzyme-catalyzed relaxation of supercoiled DNA in vitro and in vivo in yeast showed that the camptothecin resistance of these mutants arises by entirely different mechanisms. Top1N726L-catalyzed DNA relaxation was not detected in yeast. The Top1 vac protein was catalytically active; however, camptothecin was inefficient in trapping the covalent intermediate formed between the Top1 vac enzyme and DNA. Yeast cells expressing human mutant htop1 vac, with similar substitutions near the active site tyrosine Tyr-723, were also camptothecin-resistant. Surprisingly, in the absence of camptothecin, yeast rad52 mutants defective in the repair of double-stranded DNA breaks were nonviable when top1N726L or top1 vac was overexpressed but viable when htop1 vac was overexpressed. These results suggest differences between yeast and human enzyme function in vivo.
Spectral analysis and the dynamic response of complex networks (2005)

The eigenvalues and eigenvectors of the connectivity matrix of complex networks contain information about its topology and its collective behavior. In particular, the spectral density rho(lambda) of this matrix reveals important network characteristics: random networks follow Wigner's semicircular law whereas scale-free networks exhibit a triangular distribution. In this paper we show that the spectral density of hierarchical networks follows a very different pattern, which can be used as a fingerprint of modularity. Of particular importance is the value rho(0), related to the homeostatic response of the network: it is maximum for random and scale-free networks but very small for hierarchical modular networks. It is also large for an actual biological protein-protein interaction network, demonstrating that the current leading model for such networks is not adequate.
Smart Sensing System for Combined Activity Classification and Estimation of Knee Range of Motion (2015)

This paper proposes a novel wearable system and assesses its reliability in monitoring sagittal knee movement, and discriminating between activities of daily living. The system consists of a flexible conductive polymer unit, embedded into a pair of leggings at the level of the knee, interfaced with a customized sensing node for wireless data acquisition. Design constraints included the need for the system to be unobtrusive, low cost, low power, and simple to use. The wearable system was evaluated through a series of trials conducted on healthy participants, tested on two different occasions, while walking, running, and going up and down a set of stairs. The waveforms of the sensor output resemble typical knee kinematics curves. An intraclass correlation coefficient greater than 0.8 was obtained for the output signal of the sensor from which, knee movement is derived for each of the different activities. Time and frequency domain features of the signal were used to discriminate between activities. Results show good discriminative capacity of selected parameters to an accuracy of 93% when employing a random forest analytical approach. These results suggest that the system can be used accurately to monitor both knee movement and activity performed in unconstrained environments, and thus suggesting its potential use to support knee rehabilitation.
Stem-like cells in bladder cancer cell lines with differential sensitivity to cisplatin. (2012)

The cell lines demonstrate a spectrum of aldehyde dehydrogenase high (ALDH(High)) populations that correlate with resistance to cisplatin. In the two resistant cell lines, T24 and 5637, the ALDH(High) cells demonstrate increased colony formation, migration, invasion, and ability to differentiate. The resistant T24 and 5637 cell lines may serve as models to investigate alternative therapies for bladder cancer.
The Threshold of Sand Motion Under Wave Groups (2000)

Interleukin-2 (IL-2) is a pluripotent cytokine which plays a crucial role in the immune system response. Although the IL-2/IL-2 receptor (IL-2R) system has been well characterized in cells of the T lineage it is less known in B lymphocytes. The authors therefore studied the expression of the IL-2R alpha, beta and gamma subunits in human B-cell lines at different stages of maturation, by the polymerase chain reaction technique. The authors found that the alpha and beta subunits are expressed in the final stages of B-cell lineage maturation, whereas the gamma subunit is constitutively expressed during B-lymphocyte differentiation. The results indicate that the IL-2/IL-2R system, most probably, does not have a role in the early stages of B-cell differentiation, but may be involved only in the final stages of B-cell lineage ontogeny. Moreover, the ability of the different forms of IL-2R to internalize the IL-2 ligand was investigated, using the chimeric protein IL-2-PE66(4Glu). Cell lines bearing the alphagamma, betagamma and alpha betagamma forms of IL-2R were inhibited by the chimeric protein, while those bearing the gamma subunit alone did not respond to the chimera. Thus, internalization of IL-2 is most likely mediated via the alphagamma form of the IL-2R, as shown here for the first time, as well as through the betagamma and alpha betagamma IL-2R forms. However, IL-2 cannot be internalized through the IL-2R gamma subunit alone.