gebhart/patrepeval huggingface dataset:
Tissue-Specific Downregulation of Fatty Acid Synthase Suppresses Intestinal Adenoma Formation via Coordinated Reprograming of Transcriptome and Metabolism in the Mouse Model of Apc-Driven Colorectal Cancer (2022)

Altered lipid metabolism is a potential target for therapeutic intervention in cancer. Overexpression of Fatty Acid Synthase (FASN) correlates with poor prognosis in colorectal cancer (CRC). While multiple studies show that upregulation of lipogenesis is critically important for CRC progression, the contribution of FASN to CRC initiation is poorly understood. We utilize a C57BL/6-Apc/Villin-Cre mouse model with knockout of FASN in intestinal epithelial cells to show that the heterozygous deletion of FASN increases mouse survival and decreases the number of intestinal adenomas. Using RNA-Seq and gene set enrichment analysis, we demonstrate that a decrease in FASN expression is associated with inhibition of pathways involved in cellular proliferation, energy production, and CRC progression. Metabolic and reverse phase protein array analyses demonstrate consistent changes in alteration of metabolic pathways involved in both anabolism and energy production. Downregulation of FASN expression reduces the levels of metabolites within glycolysis and tricarboxylic acid cycle with the most significant reduction in the level of citrate, a master metabolite, which enhances ATP production and fuels anabolic pathways. In summary, we demonstrate the critical importance of FASN during CRC initiation. These findings suggest that targeting FASN is a potential therapeutic approach for early stages of CRC or as a preventive strategy for this disease.
Improving proactive information systems (2005)

Proactive contextual information systems help people locate information by automatically suggesting potentially relevant resources based on their current tasks or interests. Such systems are becoming increasingly popular, but designing user interfaces that effectively communicate recommended information is a challenge: the interface must be unobtrusive, yet communicate enough information at the right time to provide value to the user. In this paper we describe our experience with the FXPAL Bar, a proactive information system designed to provide contextual access to corporate and personal resources. In particular, we present three features designed to communicate proactive recommendations more effectively: translucent recommendation windows increase the user's awareness of particularly highly-ranked recommendations, query term highlighting communicates the relationship between a recommended document and the user's current context, and a novel recommendation digest function allows users to return to the most relevant previously recommended resources. We present empirical evidence supporting our design decisions and relate lessons learned for other designers of contextual recommendation systems.
Hourly storm characteristics along the U.S. West Coast: Role of atmospheric rivers in extreme precipitation (2017)

Abstract Gridded hourly precipitation observations over the conterminous U.S., from 1948 to 2002, are analyzed to determine climatological characteristics of storm precipitation totals. Despite generally lower hourly intensities, precipitation totals along the U.S. West Coast (USWC) are comparable to those in southeast U.S. (SEUS). Storm durations, more so than hourly intensities, strongly modulate precipitation‐total variability over the USWC, where the correlation coefficients between storm durations and storm totals range from 0.7 to 0.9. Atmospheric rivers (ARs) contribute 30–50% of annual precipitation on the USWC and make such large contributions to extreme storms that 60–100% of the most extreme storms, i.e., storms with precipitation‐total return intervals longer than 2 years, are associated with ARs. These extreme storm totals are more strongly tied to storm durations than to storm hourly or average intensities, emphasizing the importance of AR persistence to extreme storms on the USWC.
Being all male (2012)

Working in the area of men's and boy's health is both rewarding and challenging. Having a clinical background and interest in prostate cancer, I have seen that the field of men's health is ever changing. It requires new ideas, energy and the will to engage with men in all areas of the community. Whether informing grade 6 boys about puberty, teaching nursing graduates how to engage with men, or educating men on a mine site as to why they should look after their health, the opportunities for men's health education are endless.
Mechanical and Morphological Properties of Cellulose Fibril Reinforced Nanocomposites (2005)

The Modulus of Elasticity (MOE) and the hardness of fibril reinforced hydroxypropyl cellulose films were determined by nanoindentation. In addition, the fibril alignment in the composites was analysed by Transmission Electron Microscopy (TEM) and Atomic Force Microscopy (AFM). The results show that the formation of fibril networks is of great importance for the mechanical properties of the nanocomposites.
Networking support for query processing in sensor networks (2004)

Networking and query processing must be co-designed to allow data self-organization for flexible but efficient in-network storage, access, and processing.
A torch nozzle design to improve plasma spraying techniques (1997)

The effects of nozzle design on the plasma characteristics of supersonic flow conditions are investigated using a D.C. plasma jet under low-pressure plasma spraying conditions. Comparison is made between a 5 mm I.D. standard nozzle and a 13 mm E.D. (exit diameter) Mach 3 Laval nozzle. Emission spectroscopy is used to study the temperature and electron density distributions in the plasma jets produced by the different nozzle configurations. The effects of the observed modifications of the temperature and electron density fields on the properties of the plasma sprayed deposits are studied using Rene 80 powders which are sprayed using both types of nozzle under similar operating conditions. The results show that the M3 Laval nozzle provides a better spraying efficiency and spraying density than a standard anode nozzle under similar conditions.
Phospholipase C Activity Affinity Purifies with the Torpedo Nicotinic Acetylcholine Receptor (2010)

Nicotinic acetylcholine receptors mediate fast synaptic transmission by fluxing ions across the membrane in response to neurotransmitter binding. We show here that during affinity purification of the nicotinic acetylcholine receptor from Torpedo, phosphatidic acid, but not other anionic or zwitterionic phospholipids, is hydrolyzed to diacylglycerol. The phospholipase C activity elutes with the acetylcholine receptor and is inhibited by a lipid phosphate phosphohydrolase inhibitor, sodium vanadate, but not a phosphatidate phosphohydrolase inhibitor, N-ethylmaleimide. Further, the hydrolysis product of phosphatidic acid, diacylglycerol, enhances the functional capabilities of the acetylcholine receptor in the presence of anionic lipids. We conclude that a phospholipase C activity, which appears to be specific for phosphatidic acid, is associated with the nicotinic acetylcholine receptor. The acetylcholine receptor may directly or indirectly influence lipid metabolism in a manner that enhances its own function.
VAD FOR BRIDGE TO RECOVERY (2002)

The influence of the Ventricular Assist Devices (VAD) characteristics, operating mode and cannulation on the working condition of the Left Ventricle (LV) was studied in order to define device requirements and best control strategies for an effective use of VADs for heart recovery. A lumped parameters model of the cardiovascular system (venous return, left atrium, LV and arterial load) and of the VADs was developed in MatLab. The simulation included both continuous and pulsatile VADs. Atrium to aorta as well as apex to aorta cannulation was considered. The simulation allowed the flow and pressure to be calculated in all points, hence the pressure-volume loops, the wall tension of the LV and its afterload could he evaluated for different venous return, aortic pressure and VAD operating mode conditions. The results will be presented and show that maximal and beat to beat stable ventricular unloading, in terms of LV volume and wall tension, is best attained with apex to aorta cannulation and driving the VAD in synchronous, counterpulsating mode. In-vitro tests performed using a hydraulic simulator confirmed the simulation results. The results lead us not only to the optimisation of the control algorithms for the VAD we currently have in an advanced stage of development but also to the definition of an optimised procedure for the critical weaning phase and to the development of a special device, that will be illustrated, for its implementation. This device allows to continuously regulate the LV afterload maintaining at the same time the synchronous counterpulsating VAD assistance.
A Specific RNA Hairpin Loop Structure Binds the RNA Recognition Motifs of the Drosophila SR Protein B52 (1997)

B52, also known as SRp55, is a member of the Drosophila melanogaster SR protein family, a group of nuclear proteins that are both essential splicing factors and specific splicing regulators. Like most SR proteins, B52 contains two RNA recognition motifs in the N terminus and a C-terminal domain rich in serine-arginine dipeptide repeats. Since B52 is an essential protein and is expected to play a role in splicing a subset of Drosophila pre-mRNAs, its function is likely to be mediated by specific interactions with RNA. To investigate the RNA-binding specificity of B52, we isolated B52-binding RNAs by selection and amplification from a pool of random RNA sequences by using full-length B52 protein as the target. These RNAs contained a conserved consensus motif that constitutes the core of a secondary structural element predicted by energy minimization. Deletion and substitution mutations defined the B52-binding site on these RNAs as a hairpin loop structure covering about 20 nucleotides, which was confirmed by structure-specific enzymatic probing. Finally, we demonstrated that both RNA recognition motifs of B52 are required for RNA binding, while the RS domain is not involved in this interaction.
Twiki and wetpaint (2007)

This paper describes a community-based effort to preserve organizational knowledge and to orientate newcomers to a graduate school. It presents a very brief review of recent research on wiki use in corporate and organizational environments and initial data from two wiki implementation iterations within our academic community. We contrast use of a TWiki with that of a WetPaint wiki. Our data suggest that with low barriers to participation and a great deal of patience, wikis can be useful stores for community information and knowledge sharing.
Stress tuning in AIN thin films (1991)

Abstract Aluminium nitride films were deposited on fused silica by reactive dc magnetron sputtering from an Al‐target in an Ar/N 2 atmosphere. In‐situ measurements during deposition provided data concerning mechanical stresses inherent to the growing thin films. By variation of both the gas composition (Ar, N 2 ) and the total gas flow in the vacuum chamber, the occuring intrinsic stresses could be shifted in magnitude and direction. Stress values of the AIN films ranged from −0.9 GPa (compressive) to +1.2 GPa (tensile) when the Ar/N 2 ratio was varied between 3:1 and 1:3 for the different total gas flows of 50 sccm, 100 sccm, and 200 sccm (corresponding to total gas pressures of approximately 2 × 10 −1 Pa, 4 × 10 −1 Pa, and 8 × 10 −1 Pa respectively). Investigations of optical and structural film properties were carried out and the results were related to the observed film stress.
Massive edema of ovary with cytogenetic alteration of chromosome 12q13-15 in adolescent patient: a case report (2013)

We report a rare case, very peculiar also for its association with a massive stromal fibromatosis and for the presence, never described, of tumoral areas with CHOP gene translocation, on chromosome 12q13-15.
Lattice-based minimum error rate training for statistical machine translation (2008)

Minimum Error Rate Training (MERT) is an effective means to estimate the feature function weights of a linear model such that an automated evaluation criterion for measuring system performance can directly be optimized in training. To accomplish this, the training procedure determines for each feature function its exact error surface on a given set of candidate translations. The feature function weights are then adjusted by traversing the error surface combined over all sentences and picking those values for which the resulting error count reaches a minimum. Typically, candidates in MERT are represented as N-best lists which contain the N most probable translation hypotheses produced by a decoder. In this paper, we present a novel algorithm that allows for efficiently constructing and representing the exact error surface of all translations that are encoded in a phrase lattice. Compared to N-best MERT, the number of candidate translations thus taken into account increases by several orders of magnitudes. The proposed method is used to train the feature function weights of a phrase-based statistical machine translation system. Experiments conducted on the NIST 2008 translation tasks show significant runtime improvements and moderate BLEU score gains over N-best MERT.
FDDI and FDDI-II: Architecture, Protocols, and Performance (1994)

From the Publisher:
FDDI and FDDIII: Architecture, Protocols, and Performance provides valuable background information on local area networks and outlines trade-off considerations for network design. It explains state machines and state variables, many industry standards, and performance issues not included in the standards.
Isolation of an Antidermatophytic, Tryptanthrin, from Indigo Plants, Polygonum tinctorium and Isatis tinctoria (1980)

Key Word Index Polygonum tinctorium - Isatis tinctoria - Antidermatophytic Activity - Tryptanthrin.
LSM Proteins Provide Accurate Splicing and Decay of Selected Transcripts to Ensure NormalArabidopsisDevelopment (2012)

In yeast and animals, SM-like (LSM) proteins typically exist as heptameric complexes and are involved in different aspects of RNA metabolism. Eight LSM proteins, LSM1 to 8, are highly conserved and form two distinct heteroheptameric complexes, LSM1-7 and LSM2-8,that function in mRNA decay and splicing, respectively. A search of the Arabidopsis thaliana genome identifies 11 genes encoding proteins related to the eight conserved LSMs, the genes encoding the putative LSM1, LSM3, and LSM6 proteins being duplicated. Here, we report the molecular and functional characterization of the Arabidopsis LSM gene family. Our results show that the 11 LSM genes are active and encode proteins that are also organized in two different heptameric complexes. The LSM1-7 complex is cytoplasmic and is involved in P-body formation and mRNA decay by promoting decapping. The LSM2-8 complex is nuclear and is required for precursor mRNA splicing through U6 small nuclear RNA stabilization. More importantly, our results also reveal that these complexes are essential for the correct turnover and splicing of selected development-related mRNAs and for the normal development of Arabidopsis. We propose that LSMs play a critical role in Arabidopsis development by ensuring the appropriate development-related gene expression through the regulation of mRNA splicing and decay.
Retinol bound to cellular retinol-binding protein is a substrate for cytosolic retinoic acid synthesis. (1993)

Retinol bound to cellular retinol-binding protein (CRBP) was found to be oxidized to retinoic acid by a soluble activity from calf liver. Cytosolic retinoic acid synthesis from retinol-CRBP was strictly dependent on the exogenous supply of either NAD or NADP. NAD-supported reactions carried out in the presence or in the absence of dimethyl sulfoxide yielded apparent Km and Vmax values for the retinol-CRBP complex of 3.5 +/- 0.6 microM, 611 +/- 49 pmol h-1 (mg of protein)-1, and 0.84 +/- 0.12 microM, 601 +/- 38 pmol h-1 (mg of protein)-1, respectively. The corresponding values for the oxidation of free retinol, dissolved in dimethyl sulfoxide, were 7.1 +/- 0.3 microM and 948 +/- 47 pmol h-1 (mg of protein)-1. Since the dissociation constant of the bovine retinol-CRBP complex is less than 10(-8) M, whereas the Km for retinol-CRBP is of the same order as the Km for free retinol, synthesis of retinoic acid from retinol-CRBP does not rely on prior dissociation of retinol. ApoCRBP proved to be a specific inhibitor of retinoic acid synthesis from CRBP-bound retinol. Its inhibitory effect was indistinguishable from the dilution of the radioactive retinol-CRBP substrate that was obtained by the addition of unlabeled holoCRBP. In contrast, the oxidation of CRBP-bound retinol was not inhibited by the addition of other retinoid binding proteins nor by the addition of either free retinol or retinol complexed with proteins distinct from CRBP. These results indicate that the protein moiety of holoCRBP is specifically recognized by the cytosolic enzyme system that catalyzes retinoic acid synthesis from CRBP-bound retinol.
Regioselectivity Control in a Ruthenium-Catalyzed Cycloisomerization of Diyne-ols (2004)

The ruthenium-catalyzed cycloisomerization of diynes containing one silyl alkyne and one propargyl alcohol yields 2-silyl-[6H]-pyrans instead of the expected unsaturated acylsilanes except when additional conjugation of a aromatic ring is present at the delta-position. Under certain conditions, a facile ruthenium-catalyzed isomerization of the product takes place as well. This regioselectivity of the cyclization can be controlled by the choice of solvent system. DFT calculations confirm the expected greater stability of the silyl-pyrans relative to the acylsilanes.
Active Magnetic Bearings for the Intra-Arterial Positioning of a Clinical Microcatheter. (2016)

ZACCARDO, VICTOR MICHAEL.Active Magnetic Bearings for the Intra-Arterial Positioning of a Clinical Microcatheter (Under the direction of Dr. Gregory Buckner)
In-Flight Simulators (1986)

The Flight Dynamics Laboratory (FDL) has sponsored and managed the development and use of several generations of in-flight simulators during the last thirty years. These vehicles were designed and fabricated, and are operated by the Flight Research Department of Calspan Corporation, Buffalo, New York. These unique aircraft have been used to develop control laws and control systems, to evaluate new aircraft before first flight, to provide specialized training for test pilots, to perform essential flight research in flying and handling qualities, and to develop and validate the military specifications for handling qualitites of piloted airplanes. As aircraft and control systems have become more complex and capable, systems integration issues have required more and more effort and resources.
Variation in the Dopamine-4-Receptor Gene in Patients with Type 1 Diabetes (2023)

Our data imply that the dopaminergic signaling pathways may play an important role in the etiology of DM1 as well as its comorbidities and will provide a new insight into the DM1 risk management. The -521C&gt;T DRD4 gene polymorphism could be considered a genetic marker to predict susceptibility to DM1 as well as retinopathy and dyslipidemia progress in patients with already established disease.
Correlation between Surface Morphology and Electrical Properties of GaAs Grown by Metalorganic Chemical Vapor Deposition (1984)

Surface morphology, including growth pyramids and rough surface, formed on MOCVD grown GaAs epitaxial layers has been investigated for different ratios of As to Ga atoms during growth. Such a morphology is correlated with the electrical property of the film. More specifically, rough surface textures together with p-type conductivity of the undoped sample result simultaneously for smaller As to Ga ratios. The effect of the As to Ga ratio on surface morphology and conductivity-type conversion is different for different orientations of substrates. This fact and the formation of the growth pyramids are explained on the basis of a local deficiency of As at the growth surface.
Conditions for soft x-ray lasing action in a confined plasma column (1979)

The idea of using a multi-Z (e.g., carbon, oxygen) thin plasma column as a medium for soft x-ray lasing action is presented. A plasma confined by a strong magnetic field is first heated by a CO/sub 2/-laser, and then cools rapidly by radiation losses. This leads to a level population inversion of hydrogen-like carbon or oxygen ions. Two computational models are presented. One uses given electron temperature, T/sub e/(t), evolutions. The other uses T/sub e/(t) calculated from an energy balance equation ith CO/sub 2/-laser beam power as a parameter. According to calculations, a total gain of G > 100 is expected for 3 ..-->.. 2 and G > 10 for 4 ..-->.. 2 transitions (lambda = 182 A and lambda = 135 A, respectively) for CVI ions using a CO/sub 2/-laser beam with power approx. 5 x 10/sup 10/ W for plasma column heating.
COMPARISON OF DIFFERENT NUMERICAL TECHNIQUES FOR THE DEVELOPMENT OF A SIMULATOR OF SURFACTANT ASSISTED ENHANCED OIL RECOVERY PROCESS (2015)

In this work, a simulator is designed for enhanced oil recovery process for surfactant assisted water flooding. The system being investigated consists of three components (petroleum, water and surfactant) and two-phases (aqueous and oleic). The model equations are characterized by a system of non-linear, partial, differential equations: the continuity equation for the transport of each component, Darcy’s equation for the flow of each phase and algebraic equations. The simulator incorporates first order effects, with scope to accommodate two or three dimensions, two fluid phases and one adsorbent phase and four other components. The numerical methods used in the solution of the model equations are the orthogonal collocation, finite difference, and coherence theory techniques. Matlab computer programs were used for the numerical solution of the model equations. The results of the orthogonal collocation solution were compared with those of finite difference and coherence solutions. The results indicate that the concentration of surfactants for orthogonal collocation show more features than the predictions of the coherence solutions and the finite difference, offering more opportunities for further understanding of the physical nature of the complex problem. Also, comparison of the orthogonal collocation solution with computations based on finite difference and coherence theory methods offers possible explanation for the observed differences especially between the methods and the two different reservoirs they represent.
Sensory sensitivity in operation enduring freedom/operation Iraqi freedom veterans with and without blast exposure and mild traumatic brain injury (2016)

To examine factors associated with noise and light sensitivity among returning Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) Veterans with a self-reported history of mild traumatic brain injury (mTBI) due to blast exposure, we compared the self-report of noise and light sensitivity of 42 OEF/OIF Veterans diagnosed with mTBI resulting from combat blast-exposure to that of 36 blast-exposed OEF/OIF Veterans without a history of mTBI. Results suggest a statistically significant difference between Veterans with and without a history of mTBI in the experience of noise and light sensitivity, with sensory symptoms reported most frequently in the mTBI group. The difference remains significant even after controlling for symptoms of PTSD, depression, and somatization. These data suggest that while psychological distress is significantly associated with the complaints of noise and light sensitivity, it may not fully account for the experience of sensory sensitivity in a population with mTBI history.