gebhart/patrepeval huggingface dataset:
Rectal cancer presenting as Fusobacterium nucleatum pyogenic liver abscess: A case report (2011)

<i>Fusobacterium nucleatum</i> (<i>F. nucleatum</i>) is a non-spore forming, anaerobic, gram-negative bacteria usually associated with periodontal disease and rarely reported in association with pyogenic liver abscess. Although common symptoms of colonic cancer are well known, unusual infections may herald presence of such a cancer. <i><i>Streptococcus bovis</i></i> bacteraemia is an accepted diagnostic marker for occult colonic malignancy. We report a 72-year-old Caucasian male patient who presented to us as an emergency with <i>F. nucleatum</i> hepatic abscess and was found to have a rectal cancer on further gastrointestinal screening. Literature search suggests no previous direct association of <i>F. nucleatum</i> with colorectal cancer. The hepatic abscess was successfully treated with percutaneous drainage and intravenous antibiotics followed by definitive surgery for his cancer at a later stage A brief review of literature of association of pyogenic liver abscess and occult colonic cancer is presented.
Carotid artery recognition system: A comparison of three automated paradigms for ultrasound images (2011)

CARSgd showed very accurate AD(F) profiles coupled with a low computational burden and without the need for specific tuning. It can be thought of as a reference technique for carotid localization, to be used in automated intima-media thickness measurement strategies.
Inheritance of Cellular Resistance to the Antitumor Agent ICRF 159 in Somatic Cell Hybrids (1982)

Two independently derived sublines of Syrian hamster BHK 21 S cells that demonstrate resistance to the antitumor agent ICRF 159 (NSC-129943) were fused to sensitive cells in both intraspecific and interspecific crosses, and the responses of the resultant hybrids to the drug were determined. In intraspecific hybrids from crosses involving either of the sublines, resistance to ICRF 159 was expressed codominantly ith the hybrid response being halfway between the parental responses. In interspecific hybrids from crosses with sensitive mouse cells, resistance was also expressed but to a lesser extent than in the intraspecific hybrids. However, subsequent passaging of an interspecific hybrid resulted in an increase in the degree of resistance, which appeared to be accompanied by a loss of telocentric mouse chromosomes. The results suggested that resistance in these lines was due to an alteration in the cellular target involved in the response to ICRF 159.
Thermosensitive hydrogel system for sustained release of estradiol in a fish model (2014)

Introduction Despite the fact that sustained administration of hormones has been shown to be effective in aquaculture, at the present time, only minimal research is devoted to this issue and only a few sustained release systems have been developed and tested on fish breeding, such as cholesterol pellets implants, biodegradable microspheres, non-degradable monolithic implants and more recently, osmotic pumps. Although these systems have generally demonstrated a good performance when administrated to fish, the production and wider distribution on an industrial scale appears improbable due to the high production cost and to the difficult administration. The use of a parenteral thermogelling systems has previously been shown to be effective for controlled release of hormones when applied in different animal species. These formulations increased the relative bioavailability of steroidal hormones and resulted in the sustained release of testosterone after a single subcutaneous (s.c.) injection in rabbits. Aim of the work The purpose of this study was to develop and evaluate a delivery system comprising a thermosensitive gel for the sustained release of 17β-estradiol (E2) in fish, over an extended period of time after a single intramuscular (i.m.) injection and for the improved reproductive performance in fish. Experimentals Poloxamer 407 (LUTROL F-127) was used to formulate the thermosensitive gelling system. Rheological analysis was performed using (Stress-Tech, Reologica Instruments, Lund, Sweden) equipped with a cone-plate geometry (4/40). In vitro release of E2 was evaluated using an USP dissolution apparatus 2 (AT7 smart, Sotax, CH) equipped with teflon Enhancer Cells (Agilent, USA). In vivo studies have been performed on goldfish (Carassius auratus), analyzing the plasma concentration of both E2 and vitellogenin (VGT) with Enzyme-immunoassay (EIA) and ELISA techniques. Results and discussion The poloxamer 407 based formulation exhibited a gel point at 20°C and behaved as a Newtonian low viscosity system at temperature lower than 15°C. The results demonstrate that a single i.m. injection of the thermogel formulation containing E2 can increase relative bioavailability of the hormone resulting in prolonged presence of high plasma VTG levels. E2 and VTG levels after i.m. injection of gel-E2 remained high for more days compared to the duration observed following both oil-E2 (this study) and double E2 injection experiments. Overall, the observed levels are comparable to those of mature vitellogenic female goldfish. Conclusion This work demonstrates that the poloxamer 407 thermogelling system show the potential to work as a long-acting sustained release vehicle for steroidal hormones in fish. The fast preparation, the low cost of the main formulation components, the high versatility, together with the much easier administration compared to other prolonged release systems currently studied such as implants, make these systems particularly promising in the field of hormonal treatment in aquaculture.
Addition of Alarm Pheromone Components Improves the Effectiveness of Desiccant Dusts AgainstCimex lectularius (2009)

We demonstrate that the addition of bed bug, Cimex lectularius, alarm pheromone to desiccant formulations greatly enhances their effectiveness during short-term exposure. Two desiccant formulations, diatomaceous earth (DE) and Dri-die (silica gel), were applied at the label rate with and without bed bug alarm pheromone components, (E)-2-hexenal, (E)-2-octenal, and a (E)-2-hexenal:(E)-2-octenal blend. First-instar nymphs and adult females were subjected to 10-min exposures, and water loss rates were used to evaluate the response. Optimal effectiveness was achieved with a pheromone concentration of 0.01 M. With Dri-die alone, the water loss was 21% higher than in untreated controls, and water loss increased nearly two times with (E)-2-hexenal and (E)-2-octenal and three times with the (E)-2-hexenal: (E)-2-octenal blend. This shortened survival of first-instar nymphs from 4 to 1 d, with a similar reduction noted in adult females. DE was effective only if supplemented with pheromone, resulting in a 50% increase in water loss over controls with the (E)-2-hexenal:(E)-2-octenal blend, and a survival decrease from 4 to 2 d in first-instar nymphs. Consistently, the addition of the pheromone blend to desiccant dust was more effective than adding either component by itself or by using Dri-die or DE alone. Based on observations in a small microhabitat, the addition of alarm pheromone components prompted bed bugs to leave their protective harborages and to move through the desiccant, improving the use of desiccants for control. We concluded that short exposure to Dri-die is a more effective treatment against bed bugs than DE and that the effectiveness of the desiccants can be further enhanced by incorporation of alarm pheromone. Presumably, the addition of alarm pheromone elevates excited crawling activity, thereby promoting cuticular changes that increase water loss.
Thermodynamics of monomer partitioning in polymer latices: Effect of molar volume of the monomers (1994)

A model of the thermodn. of partitioning of moderately water-sol. monomers in polymer latex systems is developed to show deviations that occur when the molar vols. of the monomers are not similar. The model, as well as expts. with Me acrylate and cyclohexyl methacrylate in polystyrene latex systems, indicated that differences in molar vol. are scarcely significant, up to monomer molar vol. ratio values of 2
Biotransformations Of Fluoroaromatic Compounds: Accumulation Of Hydroxylated Products From 3-Fluorophthalic Acid Using Mutant Strains OfPseudomonas Testosteroni (1987)

Biotransformations of 3-fluorophthalic acid have been investigated using blocked mutants of Pseudomonas testosteroni that are defective in the metabolism of phthalic acid (benzene-1,2-dicar-boxyfic acid). Mutant strains were grown with L-glutamic acid in the presence of 3-fluorophthalic acid as inducer of phthalic acid catabolic enzymes. Products that accumulated in the medium were isolated, purified and identified as the fluoroanalogues of those produced from phthalic acid by the same strains. The previously undescribed fluorochemicals cis-3-fluoro-4,5-dihydro-4,5-dihydroxyphthalic acid (VI) and 3-fluoro-4,5-dihydroxyphthalic acid (VII) have been obtained by biotransformation of 3-fluorophthalic acid, and 3-fluoro-5-hydroxyphthalic acid (X) from (VI) by freeze drying. In addition, samples of 2-fluoro-3,4-dihydroxybenzoic acid (2-fluoroprotocatechuic acid, VIII) and 3-fluoro-4,Sdi-hydroxybenzoic acid (5-fluoroprotocatechuic acid, IX) were obtained with a mutant deficient in the ring-fission enzyme, showing that the fluorine substituent in their precursor substrate (VII) is not recognized by the decarboxylase of the pathway, which shows no preference for which carboxyl group is removed. These studies of 3-fluorophthalic acid catabolism demonstrate the opportunities available for the production of novel fluorochemicals in reasonable yields by microbial transformations.
Population pharmacokinetics of roxadustat in Japanese dialysis‐dependent chronic kidney disease patients with anaemia (2021)

Roxadustat PK in Japanese DD-CKD patients were successfully described by a population PK model. The identified key covariates included coadministration of PBs on the roxadustat bioavailability and age on clearance of roxadustat.
Scalable SIMD-Efficient Graph Processing on GPUs (2015)

The vast computing power of GPUs makes them an attractive platform for accelerating large scale data parallel computations such as popular graph processing applications. However, the inherent irregularity and large sizes of real-world power law graphs makes effective use of GPUs a major challenge. In this paper we develop techniques that greatly enhance the performance and scalability of vertex-centric graph processing on GPUs. First, we present Warp Segmentation, a novel method that greatly enhances GPU device utilization by dynamically assigning appropriate number of SIMD threads to process a vertex with irregular-sized neighbors while employing compact CSR representation to maximize the graph size that can be kept inside the GPU global memory. Prior works can either maximize graph sizes (VWC uses the CSR representation) or device utilization (e.g., CuSha uses the CW representation, however, CW is roughly 2.5x the size of CSR). Second, we further scale graph processing to make use of multiple GPUs while proposing Vertex Refinement to address the challenge of judiciously using the limited bandwidth available for transferring data between GPUs via the PCIe bus. Vertex refinement employs parallel binary prefix sum to dynamically collect only the updated boundary vertices inside GPUs' outbox buffers for dramatically reducing inter-GPU data transfer volume. Whereas existing multi-GPU techniques (Medusa, TOTEM) perform high degree of wasteful vertex transfers. On a single GPU, our framework delivers average speedups of 1.29x to 2.80x over VWC. When scaled to multiple GPUs, our framework achieves up to 2.71x performance improvement compared to inter-GPU vertex communication schemes used by other multi-GPU techniques (i.e., Medusa, TOTEM).
New donor polymer with tetrafluorinated blocks for enhanced performance in perylenediimide-based solar cells (2017)

The synthesis of a new tetrafluorinated semiconducting donor polymer <bold>PBTZF4</bold> and its OPV performance in PDI-based solar cells are reported.
Fluid-Structural Interaction Analysis of the MMC-Thixoforging Process (2006)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
High-performance polymer waveguide devices via low-cost direct photolithography process (2002)

All-optical networks provide unique opportunities for polymer waveguide devices because of their excellent mechanical, thermo-optic, and electro-optic properties. Polymer materials and components have been viewed as a viable solution for metropolitan and local area networks where high volume and low cost components are needed. In this paper, we present our recent progress on the design and development of photoresist-like highly fluorinated maleimide copolymers including waveguide fabrication and optical testing. We have developed and synthesized a series of thermally stable, (Tg>150 oC, Td>300 oC) highly fluorinated (>50%) maleimide copolymers by radical co-polymerization of halogenated maleimides with various halogenated co-monomers. A theoretical correlation between optical loss and different co-polymer structures has been quantitatively established from C-H overtone analysis. We studied this correlation through design and manipulation of the copolymer structure by changing the primary properties such as molecular weight, copolymer composition, copolymer sequence distribution, and variations of the side chain including photochemically functional side units. Detailed analysis has been obtained using various characterization methods such as (H, C13, F19) NMR, UV-NIR, FTIR, GPC and so forth. The copolymers exhibit excellent solubility in ketone solvents and high quality thin films can be prepared by spin coating. The polymer films were found to have a refractive index range of 1.42-1.67 and optical loss in the range of 0.2 to 0.4 dB/cm at 1550nm depending on the composition as extrapolated from UV-NIR spectra. When glycidyl methacrylate is incorporated into the polymer backbone, the material behaves like a negative photoresist with the addition of cationic photoinitiator. The final crosslinked waveguides show excellent optical and thermal properties. The photolithographic processing of the highly fluorinated copolymer material was examined in detail using insitu FTIR. The influence of various polymer structural parameters on the photosensitivity and photo contrast of the polymer has been evaluated in detail. The same polymeric material has been tested using hot micro-embossing and Ebeam lithography to fabricate channel waveguides and other microstructures. The versatility of this unique photocrosslinkable thermoplastic material for various passive and active optical components is discussed in detail.
Parapapillary Chorioretinal Atrophy in Patients With Ocular Hypertension (1997)

The progression of parapapillary chorioretinal atrophy may be an early glaucomatous finding in some patients with ocular hypertension.
Controlled growth of a-/b- and c-axis oriented epitaxial SrBi2Ta2O9 ferroelectric thin films (1999)

Thin films of a-/b- and c-axis oriented SrBi2Ta2O9 (SBT) were epitaxially grown on (110) MgO and (100) MgO substrates, respectively, by a rf magnetron sputtering deposition method. The orthorhombic SBT phase was confirmed by electron probe microanalysis and infrared reflectance spectra. The oriented growth was proved by transmission electron microscopy together with x-ray diffraction. The orientation relationship of the a-/b-axis oriented film with the substrates was determined to be SBT[001]//MgO[001] and SBT[010]//MgO[11̄0](SBT[100]//MgO[11̄0]) from electron diffraction patterns.
Selfassociation of daunomycin (1982)

Daunomycin, a potent anthracycline antibiotic, self-associates in aqueous solution at concentrations greater than 10 microM. We report here visible absorbance, sedimentation equilibrium, and proton nuclear magnetic resonance (NMR) experiments that characterize this self-association. In contrast to earlier reports that the process is a simple dimerization, we find that an indefinite association model best fits our data, with an intrinsic association constant, Ki, equal to 1500 M-1. From the temperature dependence of the observed NMR spectra, an enthalpy of approximately -8.0 kcal/mol is calculated. The NMR data show that the aromatic protons of the anthracycline portion of the drug are most affected by aggregation, probably due to stacking of the anthracycline rings. Knowledge of the applicable model for the self-association process, and the equilibrium constant that describes the process, enables us to assess quantitatively the possible effects of drug aggregation on the interpretation of drug-DNA binding data. For the ionic conditions most commonly used in such studies, the amount of aggregated daunomycin will be slight and may safely be ignored.
Comparison of Plasma and Urinary Methods for the Direct Measurement of the Thyroxine to 3,5,3'- Triiodothyronine Conversion Rate in Man (1984)

A further development of a new method recently proposed for the direct measurement of the conversion ratio (CR) of T4 to T3 in man is presented. [125I]T4 and [131I]T3 are injected simultaneously, and Sephadex chromatography is performed on urine samples to determine [125I]T3 formed in vivo, while plasma samples are used to measure the injected tracers. CR is calculated with the assumption that urinary [125I]T3 closely reflects [125I]T3 appearing in plasma after the injection of precursor [125I]T4. Four normal subjects and six patients with various thyroid disorders were studied using this method. The experimental data were also analyzed by our previous method based on plasma sampling only and by two recently described methods based on urinary measurements. These comparisons were made in an attempt to ascertain whether there is any systematic difference between the conversion values derived from plasma data and those derived from urinary data. Using plasma data alone, the CR was 28.6 +/- 3.4% (mean +/- SEM) in a group of four normal subjects, 37%, in two untreated hypothyroid patients, 40.2% in one hypothyroid subject receiving T4 treatment, 30.9% in one hyperthyroid patient, 24.9% in one patient with selective hyperthyroxinemia due to amiodarone treatment, and 10.7% in one normal subject after iopanoic acid administration. These values were in excellent agreement with those obtained by the modified procedure described here, in which both urinary and plasma measurements are used. Of the methods using urinary data alone, however, one gave similar results, while the other systematically overestimated the CR, possibly due to delayed excretion of labeled T4 metabolites into the urine. We conclude that 1) the analytical procedure to separate the labeled tracers and metabolites in urine or plasma is critical for the accurate estimation of CR; 2) when an adequate separation procedure is available, plasma and urinary methods for measuring CR yield comparable results; and 3) the plasma method should be used when, in addition to CR, other kinetic (distribution and turnover) parameters of T4 and T3 metabolism are to be estimated.
New Interference Approach for Ballistic Impact into Stacked Flexible Composite Body Armor (2010)

In this study a new interference model is developed to investigate the ballistic response of a hybrid, two-layered, flexible body armor. Because the stacking order of layers, which have distinctly different mechanical properties, has a large effect on the V(50) limit velocity for penetration, we apply the analysis to a two-layer system consisting of fabrics of aramid (Kevlar29 (R)) fiber and of ultrahigh molecular weight and drawn polyethylene (Dyneema (R)) fibers. Using right-circular cylindrical projectiles, previous experimental results of Cunniff ("An Analysis of the System Effects in Woven Fabrics Under Ballistic Impact," Textile Research Journal, Vol. 62,1992, pp. 495-509) [using a similar fiber, Spectra (R) instead of Dyneema (R)] showed nearly a factor of 2 difference in the V50 velocity in the two possible stacking orders, that is, Spectra (R) versus Kevlar29 (R) as the strike face. This new model extends our previous fundamental work ("A New Membrane Model for the Ballistic Impact Response and V(50) Performance of Multiply Fibrous System," International Journal of Solids and Structures, Vol. 40, 2003, pp. 6723-6765) by addressing interference factors in terms of instantaneous material inflow to the impact cone using a convolution over current local strain around the projectile edge during its deceleration. Our previous multilayer model ("Modeling of System Effects in Ballistic Impact into Multi-Layered Fibrous Structures for Soft Body Armors," International Journal of Fracture, Vol. 135, 2005, pp. 219-251) ignored the interference aspect though a subsequent work ("Effects of Layer Stacking Order on the V50 Velocity of Two-Layered Hybrid Armor System," Journal of Mechanics of Materials and Structures, Vol. 3,2008, pp. 627-639) approximated its effects but without instantaneous response of material inflow to local tensile strain. The current model is much more complete and produces velocity, strain, and deformation histories either to perforation or to halting the projectile. In the new model, V(50) velocity differences with stacking order and with layer bonding versus no bonding are even larger. However, backface deflections turn out to be minimally affected. Calculations are very fast and postprocessing figures can be obtained in less than a minute using MATLAB with a laptop (2 MHz Core 2 Duo CPU 2 Gb RAM).
Effect of Astragaloside IV on Neural Stem Cell Transplantation in Alzheimer’s Disease Rat Models (2016)

Stem cell-based therapy is a promising treatment strategy for neurodegenerative diseases such as Alzheimer's disease (AD). However, the mechanism underlying the maintenance of renewal and replacement capabilities of endogenous progenitor cells or engrafted stem cells in a pathological environment remains elusive. To investigate the effect of astragaloside IV (ASI) on the proliferation and differentiation of the engrafted neural stem cells (NSCs), we cultured NSCs from the hippocampus of E14 rat embryos, treated the cells with ASI, and then transplanted the cells into the hippocampus of rat AD models. In vitro experimentation showed that 10(-5) M ASI induced NSCs to differentiate into β-tubulin III(+) and GFAP(+) cells. NSCs transplantation into rat AD models resulted in improvements in learning and memory, especially in the ASI-treated groups. ASI treatment resulted in an increase in the number of β-tubulin III(+) cells in the hippocampus. Further investigation showed that ASI inhibited PS1 expression in vitro and in vivo. The high-dose ASI downregulated the Notch intracellular domain, whereas the low-dose ASI increased Notch-1 and NICD. In conclusion, ASI treatment resulted in improvements in learning and memory of AD models by promoting NSC proliferation and differentiation partly through the Notch signal pathway.
Response to “Comment on ‘Enhanced room-temperature emission in Cr4+ ions containing alumino-silicate glasses’ [Appl. Phys. Lett. 87, 066103 (2005)]” (2005)

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