gebhart/patrepeval huggingface dataset:
Femtosecond-laser pumped CdSiP_2 optical parametric oscillator producing 100  MHz pulses centered at 62  μm (2013)

We report the first, to the best of our knowledge, femtosecond-laser-pumped optical parametric oscillator (OPO) based on the newly developed nonlinear crystal, CdSiP₂. The OPO was synchronously pumped by a mode-locked Yb:KYW/Yb:fiber master-oscillator power amplifier, providing 1.053 μm pump pulses with durations of 130 fs at a repetition rate of 100 MHz. The 0.5-mm-thick CdSiP₂ crystal was cut for a type-I noncritical interaction, providing a broad phase-matching bandwidth and ensuring excellent temporal overlap among the pump, signal, and idler pulses. The OPO generated signal pulses with a spectral coverage over 1260-1310 nm and mid-infrared idler pulses with a broad spectral coverage at 5.8-6.6 μm (6.2 THz). With a 2% output coupler (OC), the threshold pump power was 600 mW. At the maximum pump power of 1.6 W, 0.55 W was absorbed due to two-photon absorption and residual linear absorption in the CdSiP₂ crystal, 0.75 W was transmitted, and 53 mW signal power was extracted through the OC. We estimate that the generated idler power was 24 mW.
Effects of Somatostatin on the Secretion of Thyrotropin and Prolactin (1974)

Somatostatin, a tetradecapeptide isolated from ovine hypothalamic extracts on the basis of its ability to inhibit the spontaneous secretion of growth hormone (GH) by pituitary cell cultures, has been found to inhibit the stimulated secretion of thyrotropin (TSH) mediated by TRF(pGlu-His- Pro-NH2), 10 × [K†], or theophylline in vitro, while having no effect on the secretion of luteinizing hormone (LH) due to LRF. The spontaneous release of PRL in vitro is also inhibited by somatostatin but to a lesser extent than is the spontaneous secretion of GH. In vivo, the TRF-triggered secretion of TSH but not of PRL is suppressed by somatostatin in the estrogen-progesteronepretreated male rat. The injection of TRF leads to a greater rise in both plasma TSH and PRL in estrogen-progesterone-pretreated male rats than in untreated male rats. Somatostatin acts rapidly but reversibly to inhibit the secretion of TSH due to TRF in a dose-dependent manner. Thyroid hormones and somatostatin exhibit summation in their inhibition of TSH secretion in vivo and in vitro. These data indicate the potential for somatostatin, along with thyroid hormones and TRF, to play a physiological role in the regulation of TSH secretion. (Endocrinology95: 968, 1974)
Images of biological samples undergoing sterilization by a glow discharge at atmospheric pressure (1999)

Among the various industrial uses of the glow discharge at atmospheric pressure (GDAP), biological applications such as sterilization are under investigation. In this paper, we present images of a liquid medium (Luria-Bertani broth with tetracycline) contaminated by Escherichia coli bacteria (strain PER 322) undergoing plasma treatment. In most cases, it is found that an exposure time of two to 20 minutes leads to nearly a complete kill of a 10/sup 8//ml E. coli population. The treatment time necessary to obtain a complete kill depends on the plasma power density, the type of gas used, the type of bacteria, and the type of medium.
New products, Chern classes and power operations in orbifold K-theory (2014)

Withdrawn by the authors because the results of this paper are subsumed within and improved by the two papers 
1. A plethora of inertial products and 
2. Chern Classes and Compatible Power Operations in Inertial K-theory
NAViDAd: A No-Reference Audio-Visual Quality Metric Based on a Deep Autoencoder (2019)

The development of models for quality prediction of both audio and video signals is a fairly mature field. But, although several multimodal models have been proposed, the area of audio-visual quality prediction is still an emerging area. In fact, despite the reasonable performance obtained by combination and parametric metrics, currently there is no reliable pixel-based audio-visual quality metric. The approach presented in this work is based on the assumption that autoencoders, fed with descriptive audio and video features, might produce a set of features that is able to describe the complex audio and video interactions. Based on this hypothesis, we propose a No-Reference AudioVisual Quality Metric Based on a Deep Autoencoder (NAViDAd). The model visual features are natural scene statistics (NSS) and spatial-temporal measures of the video component. Meanwhile, the audio features are obtained by computing the spectrogram representation of the audio component. The model is formed by a 2-layer framework that includes a deep autoencoder layer and a classification layer. These two layers are stacked and trained to build the deep neural network model. The model is trained and tested using a large set of stimuli, containing representative audio and video artifacts. The model performed well when tested against the UnB-AV and the LiveNetflix-II databases.
On the user selection for MIMO broadcast channels (2005)

In this paper, we consider a downlink communication system, in which a base station (BS) equipped with M antennas communicates with N users each equipped with K receive antennas. We propose an efficient suboptimum algorithm for selecting a set of users in order to maximize the sum-rate throughput of the system. For the asymptotic case of N rarr infin, it is shown that by using a very simple preceding scheme of zero-forcing beam-forming, the optimum sum-rate which behaves like M log log N can be achieved. The complexity of our algorithm is investigated in terms of the required amount of feedback from the users to the base station, as well as the number of searches required for selecting the users. It is shown that the proposed method is capable of achieving a large portion of the sum-rate capacity, with a very low complexity
Phosphorylation of cGMP-dependent protein kinase increases the affinity for cyclic AMP (1986)

Cyclic-GMP-dependent protein kinase contains two binding sites for cGMP, which have different affinities for cGMP. Autophosphorylation of the enzyme affects mainly the binding of cGMP to the 'high'-affinity site (site 1). The enzyme binds cAMP and cAMP stimulates the phosphotransferase activity of the native enzyme half-maximally at 44 microM. Autophosphorylation of the enzyme decreases the apparent Ka value to 7 microM. Autophosphorylation does not affect the catalytic rate of the enzyme if measured at a saturating concentration of ATP. Tritiated cAMP apparently binds at 4 degrees C to one site with a Kd value of 3 microM. Binding to the second site is not measurable. Autophosphorylation of the enzyme increases the affinity of the high-affinity site for cAMP sixfold (Kd 0.46 microM) and allows the detection of a second site. In accordance with these data the dissociation rate of [3H]cAMP from the high-affinity site is decreased from 4.5 min-1 to 1.2 min-1 by autophosphorylation. Experiments in which unlabeled cAMP competes with [3H] cGMP for the two binding sites confirmed these results. Recalculation of the competition curves by a computer program for two binding sites indicated that autophosphorylation decreases the Kd value for binding of cAMP to the high-affinity site from 1.9 microM to 0.17 microM. Autophosphorylation does not affect significantly the affinity for the second site. Kd values for site 2 varied from 17 microM to 40 microM. These results suggest that autophosphorylation of cGMP-dependent protein kinase increases the affinity of the enzyme for cAMP by affecting mainly the properties of binding site 1.
A −121.5 dB THD Class-D Audio Amplifier with 49 dB Suppression of LC Filter Nonlinearity and Robust to +/−30% LC Filter Spread (2021)

This paper reports a Class-D audio amplifier that uses multiloop feedback to suppress output LC filter nonlinearity by 49 dB, enabling the use of small, low-cost LC filters with ±30% spread while maintaining low distortion. Fabricated in a 180 nm BCD process, the prototype achieves a THD of −121.5 dB and a THD+N of −107.1 dB. It delivers 12W/21W into an 8-Ω/4-Ω load with 91%/87% efficiency.
The feasibility of laser experiments for measuring the permittivity spectrum of the turbulent atmosphere (1970)

The feasibility of deducing the spectrum of the permittivity fluctuations of the turbulent atmosphere from different types of laser experiments is discussed in a theoretical framework. At optical wavelengths the permittivity spectrum is proportional to the temperature spectrum. It is shown that measurements of the amplitude covariance function over short paths of the order of 10 to 30 meters will reveal information about the inner scale of turbulence and the spectral shape in the viscous dissipation range. Amplitude covariance measurements over longer paths, of the order of 100 to 2000 meters, are sensitive to the spectral shape in the inertial subrange, although they are still influenced somewhat by the inner scale. Phase measurements are quite insensitive to the spectral shape, but do give information about the outer scale of turbulence. These measurements may be performed over any reasonable path length. Angle-of-arrival measurements are extremely sensitive to the spectral shape in the inertial subrange, but the experiment would require extremely sophisticated equipment.
Optimal measurement for kinematic calibration of a six-DOF spatial robotic manipulator (2017)

In this paper, the dynamics simulation model of the spatial robotic manipulator's joint, the servo motor model and the double closed-loop servo control model are established. The electromechanical co-simulation method is used to complete the simulation analysis of the accuracy of the manipulator's joint. Then, the co-simulation model is improved through the joint accuracy experiment. The calibration method of the spatial robotic manipulator based on Coordinate Measuring Machine (CMM) is proposed. With such calibration method, the air-bearing test-platform is used to modify the D-H parameters. In the end, the accuracy calibration experiment results prove the feasibility of this calibration method.
In Vitro Performance Testing of Two Arcuate Oscillating Saw Blades Designed for Use During Tibial Plateau Leveling Osteotomy (2011)

Our results favor the Synthes blade in terms of cutting performance and the Slocum blade in terms of wear resistance.
Influence of Magnetic Field Direction on Rearrangement of Martensite Variants in an Fe-Pd Alloy (2003)

Influence of magnetic field direction on rearrangement of martensite variants in an Fe-31.2Pd(at%) single crystal has been investigated using thermal expansion measurement in a cooling process under the magnetic field applied along [001]P, [011]P and [111]P (“P” represents “parent” phase). We also observe these rearrangements of variants in the cooling processes under the magnetic field applied along [001]P, [011]P and [111]P by optical microscope. From the thermal expansion measurement and the optical microscope observation, the following results are obtained: the variants are rearranged almost perfectly into the variants whose a axes are parallel to the magnetic field applied along [001]P, imperfectly into the variants whose c axis is perpendicular to the magnetic field applied along [011]P and hardly along [111]P. We explain these results considering the following criterion: rearrangement of variants proceeds when a kind of shear stress generated by applying a magnetic field acting on the twinning plane is larger than the stress required for the rearrangement of variants.
Learning Elementary Formal Systems and an Application to Discovering Motifs in Proteins (1991)

An elementary formal system (EFS) is a logic program consisting of definite clauses whose arguments have patterns instead of first-order terms. We investigate EFSs for polynomial-time PAC-learnability and show by experiments on protein data that PAC-learning is very useful for discovering knowledge. A definite clause of an EFS is hereditary if every pattern in the body is a subword of a pattern in the head. With this new notion, we show that H-EFS (m, k, t, r) is polynomial- time learnable, which is the class of languages definable by EFSs consisting of at most m hereditary definite clauses with predicate symbols of arity at most $ ganmma $, where k and t bound the number of variable occurrences in the head and the number of atoms in the body, respectively. The class defined by all finite unions of EFSs in H-EFS(m, k, t, r) is also polynomial-time learnable. We also show an interesting series of NC-learnable classes of EFSs. As hardness results, the class of regular pattern languages is shown not polynomial-time learnable unless RP=NP. Furthermore, the related problem of deciding whether there is a common subsequence which is consistent with given positive and negative examples is shown NP-complete. As a practical application of our learning algorithm, we made experiments on learning transmembrane domains in proteins from amino acid sequences. The experimental results were quite successful.
Guest Editor's Preface (1998)

"Guest Editor's Preface." Molecular Crystals and Liquid Crystals Science and Technology. Section A. Molecular Crystals and Liquid Crystals, 322(1), p. vii
Virtualized and flexible ECC for main memory (2010)

We present a general scheme for virtualizing main memory error-correction mechanisms, which map redundant information needed to correct errors into the memory namespace itself. We rely on this basic idea, which increases flexibility to increase error protection capabilities, improve power efficiency, and reduce system cost; with only small performance overheads. We augment the virtual memory system architecture to detach the physical mapping of data from the physical mapping of its associated ECC information. We then use this mechanism to develop two-tiered error protection techniques that separate the process of detecting errors from the rare need to also correct errors, and thus save energy. We describe how to provide strong chipkill and double-chip kill protection using existing DRAM and packaging technology. We show how to maintain access granularity and redundancy overheads, even when using ×8 DRAM chips. We also evaluate error correction for systems that do not use ECC DIMMs. Overall, analysis of demanding SPEC CPU 2006 and PARSEC benchmarks indicates that performance overhead is only 1% with ECC DIMMs and less than 10% using standard Non-ECC DIMM configurations, that DRAM power savings can be as high as 27%, and that the system energy-delay product is improved by 12% on average.
TCP CRAHN: A Transport Control Protocol for Cognitive Radio Ad Hoc Networks (2012)

Cognitive Radio (CR) networks allow users to opportunistically transmit in the licensed spectrum bands, as long as the performance of the Primary Users (PUs) of the band is not degraded. Consequently, variation in spectrum availability with time and periodic spectrum sensing undertaken by the CR users have a pronounced effect on the higher layer protocol performance, such as at the transport layer. This paper investigates the limitations of classical TCP newReno in a CR ad hoc network environment, and proposes TCP CRAHN, a window-based TCP-friendly protocol. Our approach incorporates spectrum awareness by a combination of explicit feedback from the intermediate nodes and the destination. This is achieved by adapting the classical TCP rate control algorithm running at the source to closely interact with the physical layer channel information, the link layer functions of spectrum sensing and buffer management, and a predictive mobility framework that is developed at the network layer. An analysis of the expected throughput in TCP CRAHN is provided, and simulation results reveal significant improvements by using our approach. To the best of our knowledge, our approach takes the first steps toward the design of a transport layer for CR ad hoc networks.
Stereoselective total synthesis of parthenolides indicates target selectivity for tubulin carboxypeptidase activity (2019)

The 2-(silyloxymethyl)allylboration of aldehydes was established to enable stereoselective access to α-(<i>exo</i>)-methylene γ-butyrolactones under mild conditions. Acid-labile functionality and chiral carbonyl compounds are tolerated. Excellent asymmetric induction was observed for β,β'-disubstituted α,β-epoxy aldehydes. These findings led to the enantioselective total synthesis of the sesquiterpene natural product (-)-parthenolide, its unnatural (+)-enantiomer, and diastereoisomers. Among all the isomers tested in cell culture, only (-)-parthenolide showed potent inhibition of microtubule detyrosination in living cells, confirming its exquisite selectivity on tubulin carboxypeptidase activity. On the other hand, the anti-inflammatory activity of the parthenolides was weaker and less selective with regard to compound stereochemistry.
Supplemental Figure S2 from STING Promotes the Growth of Tumors Characterized by Low Antigenicity via IDO Activation (2023)

&lt;p&gt;LLC-RFP tumorigenesis and strategies to detect TILs and cells that ingested tumor cells.&lt;/p&gt;
Comparison of Radiation from Two Microprocessor Test Packages (2007)

Radiation directly from integrated circuits (ICs) packages is conventionally not considered significant since the size of the package is electrically small and not considered as an efficient antenna. However, as the technology evolves and operating frequency increases, the size of the microprocessor package is no longer electrically small. Moreover, in todays and in future mobile platforms such as notebooks and ultra-mobile devices (UMDs), the high performance wireless communication system and powerful computing system are integrated together. It is not necessary to have an efficient antenna to couple energy from the noise source to the wireless system and degrade its performance because of the sensitivity level of the wireless receiver. In this paper, the radiation from two microprocessor test packages is compared. The results show that the package design has significant impact on the radiation from the package.
Transgenic mouse models of vasopressin expression. (1993)

Arginine vasopressin is a nine-amino acid neuropeptide hormone important in the regulation of water metabolism. It also may have a role in other physiological functions, such as blood pressure regulation and the response to stress. Whole animal studies have provided a good understanding of vasopressin physiology and regulation of the normal vasopressin gene, and in vitro cell culture studies have demonstrated important features of the intracellular regulation of vasopressin gene expression. Transgenic mice provide useful models for the study of the in vivo regulation of gene expression. Previously reported mouse lines transgenic with vasopressin gene constructs have not expressed the transgene in a tissue distribution similar to that detected for the endogenous mouse vasopressin gene. An 8.2-kb genomic construct of the rat vasopressin gene, including 3 kb each of 5' and 3' flanking sequences, has been used to develop a line of transgenic mice. These animals express the transgene in a tissue-specific manner, demonstrate appropriate osmotic regulation of transgenic vasopressin mRNA, and have normal water metabolism. Animals homozygous for the 8.2-kb transgene have increased basal plasma levels of vasopressin peptide but have no apparent change in basal water metabolism. The findings with this and other previously reported mouse lines transgenic for vasopressin constructs provide a basis for developing future transgenic lines to study the in vivo regulation of the vasopressin gene.
Cell-bound complement activation products (CB-CAPs) have high sensitivity and specificity in pediatric-onset systemic lupus erythematosus and correlate with disease activity (2018)

CB-CAPs (EC4d and BC4d) have higher sensitivity and specificity than low complement in pSLE, and may help with diagnosis of pSLE. EC4d could provide a useful biomarker for disease activity monitoring.
The Development of an Advanced Anti-Icing/Deicing Capability for U.S. Army Helicopters. Volume II. Ice Protection System Application to the UH-1H helicopter (1975)

Abstract : The work which has been accomplished under this program is reported in two volumes. The first volume, Design Criteria and Technology Considerations, discusses (1) icing severity level analysis and recommended design criteria, (2) adverse weather protection technology, (3) a trade-off comparison between different types of ice protection systems for various categories of helicopters, and (4) a technology development program for an advanced electrothermal deicing system. This volume describes the application of the recommended electrothermal deicing dystem to a UH-1H test aircraft. It provides a detailed description of the modifications to the basic aircraft (including the flight test instrumentation) and the results of the ground and flight test program for that aircraft conducted in the winter of 1974-75.
Mackinac: a bridge between ModelSEED and COBRApy to generate and analyze genome-scale metabolic models (2017)

mundy.michael@mayo.edu or soares.maria@mayo.edu.
Increased photocurrent in quantum dot infrared photodetector by subwavelength hole array in metal thin film (2010)

Photocurrent enhancement in quantum dot (QD) infrared photodetector (QDIP) with an optical grating of subwavelength hole array in a thin metal film has been studied by calculating the transmission and diffraction of the infrared optical field through the grating and the light-matter interaction between the transmitted optical field and electrons confined in the QD. It is shown that due to the small aspect ratio of realistic QDs in QDIPs, the light diffraction due to the surface plasmon effect at the metal-semiconductor surface and the photonic subwavelength hole array structure is dominant in increasing the photocurrent.
Role of Conserved Cysteine Residues in Hepatitis C Virus Glycoprotein E2 Folding and Function (2012)

Hepatitis C virus glycoprotein E2 contains 18 conserved cysteines predicted to form nine disulfide pairs. In this study, a comprehensive cysteine-alanine mutagenesis scan of all 18 cysteine residues was performed in E1E2-pseudotyped retroviruses (HCVpp) and recombinant E2 receptor-binding domain (E2 residues 384 to 661 [E2(661)]). All 18 cysteine residues were absolutely required for HCVpp entry competence. The phenotypes of individual cysteines and pairwise mutation of disulfides were largely the same for retrovirion-incorporated E2 and E2(661), suggesting their disulfide arrangements are similar. However, the contributions of each cysteine residue and the nine disulfides to E2 structure and function varied. Individual Cys-to-Ala mutations revealed discordant effects, where removal of one Cys within a pair had minimal effect on H53 recognition and CD81 binding (C486 and C569) while mutation of its partner abolished these functions (C494 and C564). Removal of disulfides at C581-C585 and C452-C459 significantly reduced the amount of E1 coprecipitated with E2, while all other disulfides were absolutely required for E1E2 heterodimerization. Remarkably, E2(661) tolerates the presence of four free cysteines, as simultaneous mutation of C452A, C486A, C569A, C581A, C585A, C597A, and C652A (M+C597A) retained wild-type CD81 binding. Thus, only one disulfide from each of the three predicted domains, C429-C552 (DI), C503-C508 (DII), and C607-C644 (DIII), is essential for the assembly of the E2(661) CD81-binding site. Furthermore, the yield of total monomeric E2 increased to 70% in M+C597A. These studies reveal the contribution of each cysteine residue and the nine disulfide pairs to E2 structure and function.
ChemInform Abstract: Metal‐Mediated and Metal‐Catalyzed Oxidations Using N‐Heterocyclic Carbene Ligands (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.