gebhart/patrepeval huggingface dataset:
Isolation and characterization of new phenolic siderophores with antimicrobial properties from Pseudomonas sp. UIAU-6B (2021)

Five new phenolic siderophores <b>1</b>-<b>5</b> were isolated from the organic extract of a culture broth in a modified SGG medium of <i>Pseudomonas</i> sp. UIAU-6B, obtained from sediments collected from the Oyun river in North Central Nigeria. The structure of the new compounds, pseudomonin A-C (<b>1</b>-<b>3</b>) and pseudomobactin A and B (<b>4</b> and <b>5</b>) isolated alongside two known compounds, pseudomonine (<b>6</b>) and salicylic acid (<b>7</b>), were elucidated based on high-resolution mass spectrometry, 1D and 2D NMR analyses. The absolute configuration of the threonine residue in compounds <b>1</b>-<b>5</b> was determined by Marfey analysis. The antimicrobial evaluation of compound <b>4</b> exhibited the most potent activity against vancomycin-sensitive <i>Enterococcus faecium</i> VS144754, followed by <b>3</b> and <b>5</b>, with MIC values ranging from 8 to 32 µg/mL. Compounds <b>2</b> and <b>3</b> exhibited moderate activity against <i>Mycobacterium tuberculosis</i> H37Rv, with MIC values of 7.8 and 15.6 µg/mL, respectively. Plausible biosynthetic hypotheses toward the new compounds <b>1</b>-<b>5</b> were proposed.
Plasma Etching for Fabricating Microfluidic Devices with Patterned Monolayers (2019)

By fabricating microfluidic devices via (covalent) plasma microcontact patterning (PµCP) and replica molding, we were able create β-CD patterns inside a microfluidic channel. Chemical reactivity and reusability of the devices were validated through host-guest interactions with diadamantane functionalized Cyanine 5 dye (Cy5-Ad2).
Improved results with mital valve repair using new surgical techniques (1995)

From January 1987 to July 1994, 299 consecutive patients ranging from 4 to 80 years of age underwent mitral repair for pure valve insufficiency due to degenerative disease (59%), rheumatic disease (23%), endocarditis (12%) or ischemic heart disease (6%). During the initial period, a variety of reparative methods were used following the principles originally described by Carpentier. More recently, in our institution other surgical techniques have been introduced: specifically, prolapse of the anterior leaflet was corrected either by replacing the chordae with polytetrafluoroethylene (PTFE) sutures or simply by anchoring the prolapsing free edge to the facing edge of the posterior leaflet ("edge-to-edge" technique). Chordal transposition has also been used occasionally to correct the prolapse of the anterior leaflet. The hospital mortality rate was 1.3%. According to actuarial methods, the overall survival rate was 94% at 7 years, and freedom from reoperation was 86%. Significant incremental risk factors for reoperation were: no use of prosthetic ring, correction of the prolapse of the anterior leaflet by triangular resection or chordal shortening and ischemic etiology of the mitral insufficiency (freedom from reoperation at 7 years was 61%, 56% and 51%, respectively). In the late postoperative period (mean follow-up 3.6 years), 95% of the patients were in NYHA class I or II; four patients had thromboembolic episodes, two hemorrhagic complications and two endocarditis. No patient in whom the prolapse of the anterior leaflet was corrected by the recently introduced technique has required reoperation. The anterior mitral leaflet prolapse was therefore neutralized as an incremental risk factor for reoperation and this has contributed to the improved overall results of mitral valve repair.
Simulation of grid connected THIPWM-three-phase inverter using SIMULINK (2011)

This paper presents a grid connected system. Three phase DC-AC inverters used to convert the regulated DC power to AC power suitable for grid connection. Third harmonic injection PWM (THIPWM) was employed to reduce the total harmonic distortion (THD) and for maximum use of the voltage source. the accurate generation of THIPWM minimize the THD and make the inverter suitable for grid connection, by synchronizing the inverter voltage with the grid voltage. The application of THIPWM to inverter increases efficiency of the inverter. Simulation results validate the developed model and the proposed system.
A 6.25Gb/s binary adaptive DFE with first post-cursor tap cancellation for serial backplane communications (2005)

A 6.25 Gb/s serial receiver with a 4-tap adaptive DFE is implemented in a 0.13 /spl mu/m 7LM CMOS process. Direct cancellation of the first post-cursor ISI is achieved, enabling recovery of a data eye fully closed from channel losses and crosstalk. A BER<10/sup -15/ is measured over legacy backplane channels.
World first mode/spatial division multiplexing in multi-core fiber using Laguerre-Gaussian mode (2011)

We combined multi-core fiber technology and Laguerre-Gaussian mode to explore further increase of transmission capacity. Preservation of orbital angular momentum through multi-core fiber propagation sustained error free transmission of mode/spatial multiplexed 10 Gb/s channels.
The Small Aircraft Transportation System, Higher Volume Operations Off-Nominal Operations (2005)

*† ‡ § ** †† The ability to conduct concurrent, multiple aircraft operations in poor weather, at virtually any airport, offers an important opportunity for a significant increase in the rate of flight operations, a major improvement in passenger convenience, and the potential to foster growth of charter operations at small airports. The Small Aircraft Transportation System (SATS) , Higher Volume Operations (HVO) concept is designed to increase traffic flow at any of the 3400 non -radar, non -towered airports in the United States where operations are currently restricted to “one -in/one -out” procedural separation during Instrument Meteorological Conditions (IMC). The concept’s key feature is pilots maintain their own separation from other aircraft using procedures , aircraft flight data sent via air -to -air datalink, cockpit displays, and on -board software. This is done within the Self -Controlled Area (SCA), an area of flight operations established during poor visibility or low ceilings around an airport without Air Traffic Control (ATC) services. The research described in this paper expands the HVO concept to include most off -nominal situations that could be expected to occur in a future SATS environment. The situations were categorized into routine off -nominal ope rations, procedural deviations, equipment malfunctions, and aircraft emergencies. The combination of normal and off -nominal HVO procedures provides evidence for an operational concept that is safe, requires little ground infrastructure, and enables concur rent flight operations in poor weather.
A Context Model by Ontology and Rule for Offering the User-Centric Services in Ubiquitous Computing (2007)

Ubiquitous technology is taking charge of a core role for changing physical space which consists of devices in adaptive and distributed computing environment. It is required that various devices for each system, service and function which support moving users and fast changing context. Recent research work of the context-aware systems has focused on the ontology and reasoning. However, in the most part of context-aware systems the service management between users have not been adequately considered in respect of interoperation with classes. The context-aware systems utilize the ontology as knowledge repository, rules for organizing the services, and the agents for managing the services. Recent research work of the context-aware systems has focused on the ontology and reasoning. Although existing ontology consists of each class by functions and each class is connected by relationship in the physical environment. However the structure of context model is insufficient for classification and grouping to express the situations, environments, and services. We propose of this study is to do an ontology context service model using F-logic which is permits context information management through effective context modeling in home network.
Matrix Metalloproteinase Responsive, Proximity‐Activated Polymeric Nanoparticles for siRNA Delivery (2013)

Small interfering RNA (siRNA) has significant potential to evolve into a new class of pharmaceutical inhibitors, but technologies that enable robust, tissue-specific intracellular delivery must be developed before effective clinical translation can be achieved. A pH-responsive, smart polymeric nanoparticle (SPN) with matrix metalloproteinase (MMP)-7-dependent proximity-activated targeting (PAT) is described here. The PAT-SPN was designed to trigger cellular uptake and cytosolic delivery of siRNA once activated by MMP-7, an enzyme whose overexpression is a hallmark of cancer initiation and progression. The PAT-SPN is composed of a corona-forming PEG block, an MMP-7-cleavable peptide, a cationic siRNA-condensing block, and a pH-responsive, endosomolytic terpolymer block that drives self-assembly and forms the PAT-SPN core. With this novel design, the PEG corona shields cellular interactions until it is cleaved in MMP-7-rich environments, shifting SPNζ-potential from +5.8 to +14.4 mV and triggering a 2.5 fold increase in carrier internalization. The PAT-SPN exhibited pH-dependent membrane disruptive behavior that enabled siRNA escape from endo-lysosomal pathways. Efficient intracellular siRNA delivery and knockdown of the model enzyme luciferase in R221A-Luc mammary tumor cellssignificantly depended on MMP-7 pre-activation. These combined data indicate that the PAT-SPN provides a promising new platform for tissue-specific, proximity-activated siRNA delivery to MMP-rich pathological environments.
Reduced molybdenum phosphates: octahedral-tetrahedral framework solids with tunnels, cages, and micropores (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReduced molybdenum phosphates: octahedral-tetrahedral framework solids with tunnels, cages, and microporesRobert C. Haushalter and Linda A. MundiCite this: Chem. Mater. 1992, 4, 1, 31–48Publication Date (Print):January 1, 1992Publication History Published online1 May 2002Published inissue 1 January 1992https://pubs.acs.org/doi/10.1021/cm00019a012https://doi.org/10.1021/cm00019a012research-articleACS PublicationsRequest reuse permissionsArticle Views1091Altmetric-Citations408LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Temperature-Induced Switching between Aggregated and Nonaggregated States in Coil−Ring−Coil Block Copolymers (2009)

ADVERTISEMENT RETURN TO ISSUEPREVNoteTemperature-Induced Switching between Aggregated and Nonaggregated States in Coil−Ring−Coil Block CopolymersNico Dingenouts*†, Svetlana Klyatskaya†⊥, Sabine Rosenfeldt‡, Matthias Ballauff‡, and Sigurd Höger*§View Author Information† Institut für Technische Chemie und Polymerchemie, Universität Karlsruhe, Engesserstr. 18, 76128 Karlsruhe, Germany‡ Physikalische Chemie I, Universität Bayreuth, Universitätsstr. 30, 95440 Bayreuth, Germany§ Kekulé-Institut für Organische Chemie und Biochemie, Rheinische Friedrich-Wilhelms-Universität Bonn, Gerhard-Domagk-Str. 1, 53121 Bonn, Germany*Corresponding authors. E-mail: [email protected] (N.D.); [email protected] (S.H.).⊥Present address: Forschungszentrum Karlsruhe GmbH, Institut für Nanotechnologie, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen.Cite this: Macromolecules 2009, 42, 15, 5900–5902Publication Date (Web):July 15, 2009Publication History Received11 May 2009Revised30 June 2009Published online15 July 2009Published inissue 11 August 2009https://pubs.acs.org/doi/10.1021/ma901022whttps://doi.org/10.1021/ma901022wbrief-reportACS PublicationsCopyright © 2009 American Chemical SocietyRequest reuse permissionsArticle Views664Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Aggregation,Macrocycles,Oligomers,Scattering,Solvents Get e-Alerts
<title>Laser evaporation of the prostate: preliminary findings in canines</title> (1996)

Purpose: We evaluated the ability of KTP laser to evaporate prostatic tissue in vivo and compared the results with historical Nd:YAG treated controls. Methods: Five dogs underwent anterograde transurethral evaporation of the prostate (TUEP) with KTP laser at 38 watts and were sacrificed 48 hours after surgery. Results: All procedures were hemostatic and without complications. Laser evaporation produced cavities within the prostate ranging from 2.5 to 3.2 cm in diameter (average equals 2.9 cm) that were free of necrotic tissue. Conclusions: Preliminary findings in this initial canine study of laser evaporation of the prostate, show that KTP laser produces large spherical cavities within the prostate in a hemostatic fashion. These cavities are free of necrotic tissue. In addition, these cavities are comparable in size to those that have been observed 4 to 8 weeks following Nd:YAG VLAP and are significantly larger than the acute cavities produced by Nd:YAG TUEP.
A Microbiome DNA Enrichment Method for Next‐Generation Sequencing Sample Preparation (2016)

"Microbiome" is used to describe the communities of microorganisms and their genes in a particular environment, including communities in association with a eukaryotic host or part of a host. One challenge in microbiome analysis concerns the presence of host DNA in samples. Removal of host DNA before sequencing results in greater sequence depth of the intended microbiome target population. This unit describes a novel method of microbial DNA enrichment in which methylated host DNA such as human genomic DNA is selectively bound and separated from microbial DNA before next-generation sequencing (NGS) library construction. This microbiome enrichment technique yields a higher fraction of microbial sequencing reads and improved read quality resulting in a reduced cost of downstream data generation and analysis. © 2016 by John Wiley & Sons, Inc.
Design and Implementation of a Wireless Sensor Network Gateway Supporting Multi-Mode Wide Area Access and Video Monitoring (2009)

This paper introduces the design and implementation of a wireless sensor network (WSN) gateway with multi-mode access to Internet supporting data collection and video surveillance. The wireless sensor network collects data, while the video surveillance devices are applied for the monitoring of WSN system. Both the wired and the wireless way of Internet access are discussed. Because of the bandwidth requirement of the video stream and WSN data transmission, the 3G Internet access module is applied in the gateway in case of unreachable wired Internet access. The main architecture, the software and the hardware design of the gateway system are described separately.
Total synthesis of pandangolide 1 proposed structure (2019)

A synthetic strategy for the proposed structure of the pandangolide 1 is disclosed starting from 1,3-propane diol in 18-steps. Sharpless asymmetric dihydroxylation, Keck allylation, Yamaguchi esterification, and Grubbs ring closing metathesis were the key steps in the synthesis.
ChemInform Abstract: STEROIDS. CCLXXXII. 4‐THIA‐5‐CHOLESTEN‐3‐ONE AND SOME FURTHER STEROIDAL Δ‐THIOENOL LACTONES (1983)

Abstract Während man aus der Säure (I) unter den gegebenen Reaktionsbedingungen nur das Lacton (II) und das Acetat (III) erhält, bilden sich aus der Säure (IV) bzw. den Estern (VI) die schwefelhaltigen Steroide (V) bzw. (VII).
Analyzing the impact of Mycobacterium tuberculosis infection on primary human macrophages by combined exploratory and targeted metabolomics (2020)

The pathogenic success of Mycobacterium tuberculosis (Mtb) is tightly linked to its ability to recalibrate host metabolic processes in infected host macrophages. Since changes in cellular metabolic intermediates or pathways also affect macrophage function in response to pathogens, we sought to analyse specific metabolic alterations induced by Mtb infection. Stimulation of macrophages with Mtb lysate or lipopolysaccharide (LPS) induced a relative increase in glycolysis versus oxidative phosphorylation. Cellular metabolomics revealed that Mtb infection induced a distinct metabolic profile compared to LPS in both M1 and M2 macrophages. Specifically, Mtb infection resulted in elevated intracellular levels of nicotinamide adenine dinucleotide (NAD<sup>+</sup>), creatine, creatine phosphate and glutathione compared to uninfected control macrophages. Correspondingly, RNA-sequencing datasets showed altered gene expression of key metabolic enzymes involved in NAD<sup>+</sup>, creatine, glucose and glutamine metabolism (e.g NAMPT, SLC6A8, HK2) in Mtb-infected M2 macrophages. These findings demonstrate clear modulation of host macrophage metabolic pathways by Mtb infection.
Transgenic strategies for genetic improvement of Basmati rice. (2000)

Transgenic approach offers an attractive alternative to conventional techniques for the genetic improvement of Basmati rice because they enable the introduction of one or more genes into a leading cultivar without affecting its genetic background. During the last ten years, a rapid progress has been made towards the development of transformation methods in rice. Several transformation methods including Agrobacterium, biolistic, and DNA uptake by protoplasts, have been employed to produce transgenic rice. An array of useful genes is now available and many of these have already been transferred in rice to improve the resistance against biotic and abiotic stresses. In Basmati rice, a beginning has already been made regarding the development of tissue culture protocols, transformation methods and production of useful transgenic plants. The application and future prospects of transformation technology to engineer the resistance against insect pests (stem borer, leaf folder, brown plant hopper, gall midge), fungal diseases (blast, bakanae/foot, rot), bacterial diseases (bacterial leaf blight, sheath blight), abiotic stresses (salinity and drought) and improved nutritional quality (accumulation of provitamin A and essential amino acids in endosperm) in Basmati rice, have been addressed.
Carrying a flexible payload with multiple flying vehicles (2013)

This paper introduces a method for carrying a flexible payload with multiple attached flying vehicles. A model for a particular class of flexible structures is presented, and an estimator is derived that observes the pose of the structure in space as well as the magnitude of some characteristic deformation modes. A control strategy that controls the flexible payload to a desired pose while also controlling the deformations to zero is introduced. The presented methods are validated in the ETH Zurich Flying Machine Arena by flying with a thin, flexible ring that is carried by six quadrocopters.
French data on the epidemiology and expert healthcare network for epidermolysis bullosa (2022)

International audience
Scour depth measurements at Caisson Pier, Ohau River (1985)

Scour of bridge piers is of concern to engineers both because failures still occur through under-design and because there is much design work to be done as many old bridges are routinely renewed. In the present study, scour at a full-sized experimental pier was measured in the cobble-bedded Ohau River during discharges equivalent to a fifty year flood. The depth of the hole scoured around the pier was found to be 40 percent of the approach flow depth over a range of approach flow depths and under 'live-bed' conditions in which cobbles (0.2 m diameter) were being transported past the pier. This field study, the first of its type, did not confirm results from extensive laboratory studies over many years and indicates new directions for further laboratory work.
Inhibition of HIV-1 reverse transcriptase by RNA aptamers in Escherichia coli (2003)

A better understanding of aptamer function in bacteria would help to establish simple model systems for screening RNA-protein interactions within an intracellular context. Escherichia coli DNA polymerase I mutants (Pol I(ts)) fail to grow at 37 degrees C unless an exogenous DNA polymerase such as HIV-1 reverse transcriptase (RT) is expressed within the cell. Here, we show that four RNA aptamers that inhibit HIV-1 RT in vitro block complementation by HIV-1 RT when expressed in vivo. No other essential functions are impaired by aptamer expression at either temperature. Intracellular aptamer RNA concentrations from induced cultures were measured to range from 76 to 180 nM, which is comparable with exogenously expressed HIV-1 RT levels in these cells. RT polymerase activity was reduced to background levels in cell-free extracts prepared from cultures expressing both HIV-1 RT and the 70.28 aptamer, compared with extracts from cultures expressing HIV-1 RT alone. Intracellularly expressed RNA aptamers can thus be used to generate conditional null mutants in bacteria by titrating an essential protein.
Clinical Management of Potential Bioterrorism-Related Conditions (2015)

The agents most likely to be used in bioterrorism attacks are reviewed, along with the clinical syndromes they produce and their treatment.
Role of the Costimulatory Molecule CD28 in the Development of Lupus in MRL/ lpr Mice (1999)

MRL/Mpj-lpr/lpr (MRL/lpr) mice develop autoimmune disorders, including lymphoproliferation, glomerulonephritis, autoantibody production, and hypergammaglobulinemia. To investigate the role of the costimulatory molecule CD28 in the development of these disorders, MRL/lpr mice lacking CD28 were generated by gene targeting. Compared with CD28+/+ MRL/lpr mice, CD28-/- MRL/lpr mice showed decreased lymphadenopathy but increased splenomegaly associated with the expansion of abnormal B220+ TCRalphabeta+ T cells. Although levels of IgM Abs were unchanged in CD28-/- MRL/lpr mice, the production of anti-DNA IgG Abs and IgG rheumatoid factors were suppressed. IgG deposition in the glomeruli was markedly decreased, and the development of glomerulonephritis was significantly retarded. Furthermore, renal vasculitis and arthritis were absent in CD28-/- MRL/lpr mice. These results indicate that, although CD28 is not required for the generation of the abnormal T cell population in MRL/lpr mice, it does play an important role in the development of autoimmune disease in these animals.