gebhart/patrepeval huggingface dataset:
The susceptibility of anaerobic bacteria to rosamicin, erythromycin and clindamycin and factors affecting the activity of rosamicin (1979)

Journal Article The susceptibility of anaerobic bacteria to rosamicin, erythromycin and clindamycin and factors affecting the activity of rosamicin Get access Yung-Yuan Kwok, Yung-Yuan Kwok Research and Medical Services, Wadsworth V.A. Hospital Center, and Department of Medicine, University of CaliforniaLos Angeles, California 90073, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar Vera L. Sutter, Vera L. Sutter Research and Medical Services, Wadsworth V.A. Hospital Center, and Department of Medicine, University of CaliforniaLos Angeles, California 90073, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar Ildiko Oberhammer, Ildiko Oberhammer Research and Medical Services, Wadsworth V.A. Hospital Center, and Department of Medicine, University of CaliforniaLos Angeles, California 90073, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar Sydney M. Finegold Sydney M. Finegold Research and Medical Services, Wadsworth V.A. Hospital Center, and Department of Medicine, University of CaliforniaLos Angeles, California 90073, U.S.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Antimicrobial Chemotherapy, Volume 5, Issue 1, January 1979, Pages 61–66, https://doi.org/10.1093/jac/5.1.61 Published: 01 January 1979 Article history Accepted: 04 August 1978 Published: 01 January 1979
[Value of the transcranial Doppler examination in the diagnosis of brain death]. (1993)

Transcranial Doppler is a good method for confirming the clinical diagnosis of brain death, fundamentally in patients undergoing treatment with drugs depressing the central nervous system.
Deformation and failure mechanisms of loose and dense fill slopes with and without soil nails (2008)

Although fill slopes have been constructed worldwide to meet the needs and development of various human activities for years, the effects of fill density, material type, including gap-graded or well-graded soils, various stabilisation methods, including soil nails, and destabilising agents, including rainfall infiltration, rising ground water and earthquakes, are still not well understood. In this paper, various studies of deformation and failure mechanisms of unreinforced and nailed fill slopes using a geotechnical centrifuge are described and key findings are reported and explained.
Elevated ambulatory blood pressure in 20 subjects with Williams syndrome (1999)

Previous studies report conflicting frequencies of hypertension in cohorts of patients with Williams syndrome (WS). We studied blood pressure (BP) in WS using 24-hour ambulatory BP monitoring. This technique reliably measures day- and nighttime BP in a subject's natural environment and provides better prognostic information on long-term risks of hypertension than casual BP determinations. Twenty WS subjects evaluated through a multidisciplinary WS clinic and 35 age and gender-matched controls were studied. We found that WS subjects had significantly higher ambulatory BP than controls. After controlling for age, sex, and weight, the diagnosis of WS added approximately 10 mmHg to mean daytime and nighttime BPs. Hypertension, as defined by elevated mean daytime BP, was present in 40% of WS subjects versus 14% of controls (P < 0.05); among the children studied this difference was even more dramatic with 46% of WS children versus 6% of control children classified as hypertensive (P = 0.01). We also demonstrated normal diurnal BP variation but no evidence of a "white coat" effect or increased BP variability. Interestingly, parental reporting of a history of infantile hypercalcemia was strongly associated with the presence of hypertension (P = 0.008). Our data demonstrate that both children and adults with WS have higher mean BP and higher frequency of hypertension than healthy controls. Thus, elevated BP readings in the office setting should not be dismissed but require more thorough assessment.
Errors in characterization and modeling undermine the report of the synthesis of γ-graphyne via alkyne metathesis (2023)

The recent Article by Zhang, Zhao and coworkers describes an attempt to synthesize γ-graphyne, an sp1-sp2 allotrope of carbon. We argue that the characterization of the material reported by the authors is inconsistent with the postulated structure of bulk γ-graphyne. Therefore, the primary claim of the Article, successful synthesis of γ-graphyne, should be reevaluated.
Use of a Volumetric Target for Image-guided Surgery (2006)

A VIRTUAL REALITY system has been devised to superimpose a computer-generated rendering of a volumetric target to be surgically approached or resected on a real-time video image of the surgical field. A stereotactic frame is used to register the image from the video camera with the image of the target volume for accurate localization. The volumetric target is obtained from preoperative imaging studies and can be modified to adjust the intended line of resection or to avoid eloquent vascular or neural tissue. The computer-generated image is updated throughout surgery to visualize only that part of the tumor under resection so the surgeon may guide the resection along the border of the mass or intended preplanned line of resection. To date, 74 intracranial tumor resections have been performed under video virtual reality guidance. Postoperative scanning corresponds in every case with preoperative planning. This system is also designed to be adapted to frameless guidance, which can be further enhanced by the incorporation of an audible tone to signal the relationship of the tip of the resection instrument to the line of resection.
Listeria monocytogenes regulates flagellar motility gene expression through MogR, a transcriptional repressor required for virulence (2004)

Previous studies have shown that Listeria monocytogenes flagellar motility genes, including flaA, encoding flagellin, are transcriptionally down-regulated at 37 degrees C. For some L. monocytogenes strains, temperature-dependent motility gene expression is less stringent. By using flaA-lacZ transcriptional fusions, we identified regions upstream of the -35/-10 promoter elements that are necessary for temperature-dependent expression of flaA in L. monocytogenes strain EGDe. Whereas the sequence of the flaA promoter region was identical in L. monocytogenes strain 10403S, transcriptional activity was only partially down-regulated at 37 degrees C in 10403S. This finding suggested that a transacting regulatory protein with differential expression or activity in EGDe might be involved in temperature-dependent transcription of flaA. Indeed, a protein factor capable of specifically binding to the flaA promoter region was identified in cytoplasmic extracts of EGDe by using affinity purification and MS. Deletion of the factor-encoding gene (lmo0674) resulted in loss of temperature-dependent flaA expression and an increase in flaA promoter activity. Expression of other motility genes was also deregulated in the lmo0674 deletion. We have designated lmo0674 as mogR, indicating its role as a motility gene repressor. In tissue culture models, MogR repression of flaA during intracellular infection was independent of temperature and a deletion of mogR reduced the capacity for cell-to-cell spread. During in vivo infection, a deletion of mogR resulted in a 250-fold decrease in virulence. These studies indicate that regulation of flagellar motility gene expression and/or other genes controlled by MogR is required for full virulence of L. monocytogenes.
Case Study Gallus Labelfire 340: Guiding Question to Choose a Hybrid Inline Label Converting System (2017)

This chapter provides “Gallus Labelfire 340”, a fully integrated inline digital converting system, which is based on the fastest selling inline flexo press, the Gallus ECS340. It also provides some guiding questions to choose a hybrid inline label converting system. It is equipped with a corona and two flexo stations that can be used for substrate conditioning by applying a primer onto the substrate or to apply a plane layer of flexo white on transparent substrates or for cold-foiling. cold-foiling. In the middle, the digital print unit is placed followed by an inline coating unit with a die-cutting station and a double rewinder option. A fully integrated digital converting system adjusts its performance data for all conventional finishing processes to support the characteristics of the primary digital print. A wide dynamic range of drop sizes is necessary to have the possibility for high coverage printing or the usage of different kinds of nozzle compensation strategies.
A pulse-shaped power amplifier with dynamic bias switching for IR-UWB transmitters (2012)

This paper presents a pulse-shaped power amplifier (PSPA) design for delay line based IR-UWB transmitters. By utilizing an array of CMOS transmission gates as a dynamic bias scheme, the switched PA generates desired output pulse with negligible static current. The PSPA designed in 65nm CMOS generates UWB pulses with a -10dB bandwidth of 2.7GHz and a center frequency of 5GHz and achieves reconfigurable pulse shaping with high power efficiency. Simulation results show that the energy consumption of the PA is 3pJ/pulse with a typical current efficiency of 90% at a data rate of 200Mbps.
Supplementary Figure 5 from HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase (2023)

&lt;p&gt;TruRegistry of HER2BOW tissues&lt;/p&gt;
Single Image Super-Resolution via Multi-Scale Information Polymerization Network (2021)

Recently, the performances of deep convolution neural networks (CNNs)-based single-image super-resolution (SISR) have been significantly improved. However, most of the existing CNN-based SISR methods mainly focus on wider or deeper networks and ignore the potential relationship between multi-scale features, leading to the limited representation ability of the reconstructed network. To address this problem, we propose a new multi-scale information polymerization network (MIPN). Specifically, we propose a multi-scale information polymerization block (MIPB), which uses convolution layers of different convolution kernel sizes to extract multi-scale image features, and effectively polymerizate the extracted features together to obtain fine image features. Moreover, we also propose a shallow residual block in MIPB. Compared with the traditional convolution layer, this proposed block can effectively extract image features without increasing the number of parameters. Extensive experiments show that the proposed method performs better than several state-of-the-art methods in quantitative and visual quality indicators.
Association between health status and sociodemographic, clinical and treatment disparities in the Patient-centered Outcomes Related to TReatment Practices in Peripheral Arterial Disease: Investigating Trajectories (PORTRAIT) registry (2018)

Patients with peripheral artery disease (PAD) and intermittent claudication (IC) have impaired functional status and quality of life. However, little is known about which factors are associated with poorer health status at the time of initial presentation for PAD specialty care. Characterization of such features might provide insight into disparities that impact health status in this population. A total of 1258 patients from the United States, the Netherlands and Australia with new or worsened IC were enrolled at their first PAD specialty care visit between June 2011 and December 2015. The mean Peripheral Artery Questionnaire (PAQ) Summary Score (range 0-100), a disease-specific health status measure, was 49.2 ± 21.9. Hierarchical, multivariable linear regression was used to relate patient characteristics to baseline PAQ. Patient characteristics independently associated with poorer health status were age ( p < 0.001), female sex ( p < 0.001), not being married ( p = 0.02), economic burden (moderate/severe vs none, moderate/severe vs some; p = 0.03), difficulty getting care (moderate/severe vs none, moderate/severe vs some; p < 0.001), chronic lung disease ( p = 0.02), back pain ( p < 0.001), bilateral vs unilateral PAD ( p = 0.02), intermittent claudication severity (moderate vs mild, severe vs mild, p < 0.001), and lack of prior participation in an exercise program ( p = 0.005). Disparities in both vascular and non-vascular factors were associated with patients' health status at the time of presentation and should be addressed by all who care for patients with vascular disease.
EPIMERISATION OF 2-SUBSTITUTED 5,5-DIMETHIL-THIAZOLIDINE-4-CARBOXYLIC ACID (1979)

Abstract In conection with our work on 2-monosubstituted 5,5-dimethylthiazolidine-4-carboxylic acid we report the epimerisation of some derivatives of penicilloic acid(I) derived from 6-epipenicillins.
Un Spectrum en nuestro pingüino (2001)

El Spectrum fue sin lugar a dudas el ordenador mas vendido en nuestro pais durante los anos 80, y aun hoy despierta entusiasmo entre aquellos que lo utilizaron.
Hyperspectral Solar Spectral Measurements and Applications (2007)

Measurements of hyperspectral solar irradiance from aircraft and satellite are applied to a variety of cloud and aerosol remote sensing, and radiative energy budget applications. The direct retrievals of cloud effective radius and optical thickness are compared with more standard methods from MODIS and the MODIS Airborne Simulator. Retrievals of cloud properties in the vicinity of elevated aerosol loading are examined for potential biases in cloud retrievals. Aerosol spectral radiative forcing efficiency is derived from airborne measurements in regions of gradients in aerosol optical depth. Finally, the variability in solar spectral irradiance measured during SORCE is used to derive differential heating in the lower atmosphere.
Design of a 5.2 GHz circularly polarized textile patch antenna for on/off body radio propagation channel evaluation (2016)

This paper presents a lightweight and simple structure of slotted circularly polarized (CP) patch antenna using conductive textile. ShieldIt Super is used as a conductive textile and felt is used as a substrate of the antenna. The prototype is designed with a total dimension of 36 mm × 36 mm and spaced by a 3 mm thick felt fabric for Body-centric Wireless Communication (BCWC) operating in the 5.2 GHz Industrial, Scientific and Medical (ISM) Hyper Local Area Network (LAN) band. A parametric study has been carried out in order to investigate the antenna basic characteristics, thereby enhancing the antenna performance. The proposed antenna is benchmarked against the without slot circularly polarized textile patch antenna. The measured results show that the slotted CP patch textile antenna produces better performance compared to the without the slot CP patch textile in terms of bandwidth with an acceptable 3-dB axial ratio bandwidth and gain.
Polynomial Bottleneck Congestion Games with Optimal Price of Anarchy (2010)

We study {\em bottleneck congestion games} where the social cost is determined by the worst congestion of any resource. These games directly relate to network routing problems and also job-shop scheduling problems. In typical bottleneck congestion games, the utility costs of the players are determined by the worst congested resources that they use. However, the resulting Nash equilibria are inefficient, since the price of anarchy is proportional on the number of resources which can be high. Here we show that we can get smaller price of anarchy with the bottleneck social cost metric. We introduce the {\em polynomial bottleneck games} where the utility costs of the players are polynomial functions of the congestion of the resources that they use. In particular, the delay function for any resource $r$ is $C_{r}^\M$, where $C_r$ is the congestion measured as the number of players that use $r$, and $\M \geq 1$ is an integer constant that defines the degree of the polynomial. The utility cost of a player is the sum of the individual delays of the resources that it uses. The social cost of the game remains the same, namely, it is the worst bottleneck resource congestion: $\max_{r} C_r$. We show that polynomial bottleneck games are very efficient and give price of anarchy $O(|R|^{1/(\M+1)})$, where $R$ is the set of resources. This price of anarchy is tight, since we demonstrate a game with price of anarchy $Ω(|R|^{1/(\M+1)})$, for any $\M \geq 1$. We obtain our tight bounds by using two proof techniques: {\em transformation}, which we use to convert arbitrary games to simpler games, and {\em expansion}, which we use to bound the price of anarchy in a simpler game.
β 2 INTEGRIN COMPLEMENT RECEPTOR 3 (CR3, CD11b/CD18) REGULATION OF NEUTROPHIL FUNCTION (2009)

Complement receptor 3 (CR3, CD11b/CD18) is a β 2 integrin that is unique among integrins in that it contains a polysaccharide binding lectin‐like domain (LLD), in addition to the conventional binding domain (I‐domain). The ligands for the I‐domain are many, such as iC3b, ICAM‐1, fibronectin and fibrinogen. The LLD is a polysaccharide binding site to which a structure known as beta (β) (1‐3) D‐glucan can bind. A number of neutrophil functions have been shown to be altered, including adhesion, diapedesis, chemotaxis and cytotoxicity, depending on single or dual ligation of CR3. Our goals are to analyze downstream signaling pathways once the I‐domain alone is bound; once the LLD alone is bound; once both domains are bound. We hypothesize that single or dual ligation of CR3 will result in stimulation of different intracellular pathways, determining the character of the cell. Experiments will be done using neutrophils isolated from human blood and stimulated with antibodies or ligands directed against the I‐domain and/or LLD. Once the domain specific stimuli have been thoroughly distinguished, mass spectrometric analysis will be done to analyze downstream signaling pathways upon binding of individual or both domains. Ultimately, these studies are expected to render new signaling pathways for CR3. These various pathways will provide fundamental targets for anti‐inflammatory pharmacological therapies.
Preliminary Evidence That High-Dose Vitamin C has a Vascular Disrupting Action in Mice (2014)

High intravenous doses of vitamin C (ascorbic acid) have been reported to benefit cancer patients, but the data are controversial and there is incomplete knowledge of what physiological mechanisms might be involved in any response. Vitamin C is taken up efficiently by cells expressing SVCT2 transporters and since vascular endothelial cells express SVCT2, we explored the hypothesis that administration of high-dose vitamin C (up to 5 g/kg) to mice might affect vascular endothelial function. A single administration of vitamin C to mice induced time- and dose-dependent increases in plasma concentrations of the serotonin metabolite 5-hydroxyindole acetic acid (5-HIAA), a marker for vascular disrupting effects. Responses were comparable to those for the tumor vascular disrupting agents, vadimezan and fosbretabulin. High-dose vitamin C administration decreased tumor serotonin concentrations, consistent with the release of serotonin from platelets and its metabolism to 5-HIAA. High-dose vitamin C also significantly increased the degree of hemorrhagic necrosis in tumors removed after 24 h, and significantly decreased tumor volume after 2 days. However, the effect on tumor growth was temporary. The results support the concept that vitamin C at high dose increases endothelial permeability, allowing platelets to escape and release serotonin. Plasma 5-HIAA concentrations could provide a pharmacodynamic biomarker for vitamin C effects in clinical studies.
PRISM: A data management system for high‐throughput proteomics (2006)

Advanced proteomic research efforts involving areas such as systems biology or biomarker discovery are enabled by the use of high level informatics tools that allow the effective analysis of large quantities of differing types of data originating from various studies. Performing such analyses on a large scale is not feasible without a computational platform that performs data processing and management tasks. Such a platform must be able to provide high-throughput operation while having sufficient flexibility to accommodate evolving data analysis tools and methodologies. The Proteomics Research Information Storage and Management system (PRISM) provides a platform that serves the needs of the accurate mass and time tag approach developed at Pacific Northwest National Laboratory. PRISM incorporates a diverse set of analysis tools and allows a wide range of operations to be incorporated by using a state machine that is accessible to independent, distributed computational nodes. The system has scaled well as data volume has increased over several years, while allowing adaptability for incorporating new and improved data analysis tools for more effective proteomics research.
Development of Conductive and Anticorrosive Paint Dispersed with Carbon Particles for Metal Separators of PEFC (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Grouting in Karst Terrane—Concepts and Case Histories (2003)

Throughout the United States and especially on the east coast, development pressures have increased construction atop carbonate rocks. A myriad of concepts and techniques for identifying and remediating karst hazards has been proffered, many reasonable, some not so. Only remediation by grouting is discussed herein. The difference between effective and ineffective technique for both the identification and remediation of karst are related to the nature of the subsurface, the likely failure mechanism, and the type of construction. Bedrock character, bedding orientation, tectonic alteration, glacial activity, nature of the overburden, as well as the location and size of soil or rock cavities, will influence the failure mechanism in some way. In addition, the nature of any planned or existing construction can modify the manner, extent and procedures of the grouting operations. Any cost-effective grouting program in solutioned carbonates must consider all of the above concerns. Grouting can be as simplistic as filling the "throats" of isolated sinkholes with an appropriate "flowable fill" to a full-fledged exploratory/grouting program using compaction and/or slurry grouting techniques below a major structure. Developing an accurate cost estimate varies from quite difficult to impossible. Case histories of successful remediation operations that consider these concepts are presented herein.