gebhart/patrepeval huggingface dataset:
Adjuvant Effect of Grifolan on Antibody Production in Mice. (1998)

The effects of grifolan (GRN), a gel-forming (1-->6)-branched (1-->3)-beta-D-glucan, on antibody production were examined. Sera from mice that were injected with GRN and trinitrophenyl ovalbumin (TNP-OVA) intraperitoneally showed a significantly increased level of anti-TNP IgG. However, injection of TNP-OVA alone showed a lower antibody level. Two hundred fifty microg of GRN and 10 microg of TNP-OVA gave the maximum production of anti-TNP antibody. Enhanced antibody production was also observed in the culture supernatant of splenocyte obtained from GRN-administered mice. The culture supernatant contained a significant amount of nitric oxide (NO) in the case of GRN-administered mice. To observe the effect of NO on the antibody production induced by GRN, N-monomethyl arginine (NMMA), an inhibitor of NO synthetase, was added to the splenocyte cultures. The antibody level of supernatants containing NMMA was higher than that of control supernatants. These results suggest that GRN can enhance antibody production and that NO induced by stimulation with GRN concomitantly with antibody production is a negative factor on the adjuvant activity. Inhibition of NO may increase the adjuvant effect of GRN.
Quantitative elasticity imaging (1993)

Quantitative elasticity imaging is investigated for a wide range of gel-based, tissue equivalent phantoms and excised tissue specimens. To do this, strain imaging methods have been developed for very large surface deformations. Images produced by this approach exhibit a high signal to noise ratio (SNR). Results are presented demonstrating both the accuracy and sensitivity of the method for imaging internal strain in models of kidney pathology. In particular, strain images have been used to detect renal scar in a rabbit model of chronic nephritis before any detectable change in kidney function. Finally, reconstruction of the elastic modulus based on these high SNR strain images has been tested. Results on gel-based phantoms indicate that a method based on stress continuity can be used to clearly identify bounded inclusions in an otherwise infinite, homogeneous medium
Synthesis of Functional Methylphosphane-Borane Derivatives I. Convenient Syntheses of Tirmethylphosphane-Borane and Trimethylphosphane-Monohaloboranes (1985)

Abstract Improved high-yield syntheses of trimethylphosphane-borane, -monochloroborane and -monobromoborane are described. The first process utilizes the reaction of trimethylphosphane with monoborane generated in situ. The latter preparations are by reaction of trimethylphosphane with the tetrahydrofuran adduct of monochloroborane and by the reaction of trimethyl-phosphane-borane with gaseous hydrogen bromide in solution, respectively.
ChemInform Abstract: SYNTHESES BASED ON DIMETHYLPYRAZOLES. III. DERIVATIVES OF VINYL‐ AND 1,4‐DIVINYLBENZENES (1981)

Abstract Wie im Formelschema angegeben werden die 1,4‐Divinylbenzolderivate (VI) und (XIV) sowie das Monovinylderivat (IX) hergestellt.
The Use of the Rotary Voltmeter for Measurements up to 830 Kilovolts (1935)

The rotary voltmeter is shown to be a practical instrument for the measurement of both voltages and wave forms up to 830 kilovolts peak. A comparison of voltages so measured with the sphere gap shows that a downward revision of the A. I. E. E. standards is necessary.
Recursive delay estimation and demodulation of asynchronous DS-CDMA signals (2002)

We compare several near-far resistant recursive delay tracking algorithms and propose a robust multiuser detection scheme for asynchronous DS-CDMA systems. The delay tracking algorithms are based on the so-called 'propagator method' which permits direct update of the noise subspace from the collected data via a chosen criterion. The estimated delays are then used to demodulate the received signal using a robust formulation of the decorrelating receiver. We compare the tracking performance of the LMS, exponentially weighted RLS, exponentially weighted H/sup /spl infin// and time-varying H/sup /spl infin// solutions, and also compare the performance of our robust receiver with the decorrelating and MMSE receivers.
The Utilization of Procedure Models in Digital Image Synthesis (1975)

Abstract : Many algorithms have been developed for synthesizing shaded images of three dimensional objects modeled by computer. In spite of widely differing approaches the current state of the art algorithms are surprisingly similar with respect to the richness of the scenes they can process. One attribute these algorithms have in common is the use of a conventional passive data base to represent the objects being modeled. This paper postulates and explores the use of an alternative modeling technique which uses procedures to represent the objects being modeled. The properties and structure of such 'procedure models' are investigated and an algorithm based on them is presented.
Transient Stability Enhancement Control Strategy Based on Improved PLL for Grid Connected VSC during Severe Grid Fault (2020)

In this article, the transient synchronization process of the grid-connected voltage source converters (VSC) is studied detailly. Firstly, the phase-locked loop (PLL)-synchronized VSC is modeled according to the rotor motion equation of synchronous generator (SG). Furthermore, the VSC's damping ratio is derived, and the effects of the VSC's control parameters and the operation status on the equivalent power angle (EPA) is investigated. Moreover, the influence of the PLL's parameters and the voltage dips degree on the VSC's transient frequency behavior are analyzed. Analysis result reveals that the VSC's damping ratio decreases once the grid voltage drops, so that the EPA and frequency of the VSC may appear large overshoot and oscillation, which may trigger the frequency protection and deteriorate the VSC's transient stability. In order to ensure that the VSC can smoothly operate to new equilibrium points, an improved PLL is proposed, which can adaptively adjust the VSC's damping ratio for different voltage sags. The proposed method can not only reduce the overshoot of the EPA but also restrain the VSC's frequency dips degree. Finally, the simulations and experimental tests validate the effectiveness of the theoretical analysis.
Cellular Uptake of Imatinib into Leukemic Cells Is Independent of Human Organic Cation Transporter 1 (OCT1) (2013)

These data clearly demonstrate that cellular uptake of imatinib is independent of OCT1, and therefore OCT1 is apparently not a valid biomarker for imatinib resistance.
Bufodienolides as Endogenous Na+, K+-ATPase Inhibitors: Biosynthesis in Bovine and Rat Adrenals (1998)

The biosynthesis of digitalis-like compounds (DLC) was determined in bovine and rat adrenal homogenates by following changes in the concentration of DLC using three independent sensitive bioassays: inhibition of [3H]-ouabain binding to red blood cells and competitive ouabain and bufalin ELISA. The amounts of DLC in bovine and rat adrenal homogenates, as measured by the two first bioassays, increased with time when the mixtures were incubated under tissue culture conditions. These results suggest that Na+, K+-ATPase inhibitors which interact with ouabain antibodies, but not those which interact with bufalin antibodies, are synthesized in bovine and rat adrenals.
Magnetic Resonance, Pathology and Physiology of the BA1112 Rhabdomyosarcoma In Vivo (1988)

We studied histology, findings on H-1 magnetic resonance (MR) imaging, and correlations of P-31 MR spectroscopy with microelectrode pH and pO2 measurements in the BA1112 rhabdomyosarcoma in WAG/Rij/Y rats. Intratumoral hemorrhage was a prominent feature on MR images and pathologic specimens. Eosinophilic necrosis could be seen microscopically but was not discernible on images. The peaks seen on P-31 MR spectra were similar to those reported in other tumors. The intratumoral pH was neutral despite low pO2 values and P-31 MR evidence for impaired metabolic status.
G314(P) Can multidisciplinary simulation in a paediatric department improve clinical governance? (2015)

<h3>Background</h3> Simulation is increasingly becoming an integral part in paediatric teaching. It offers an excellent opportunity to practice medical emergencies in a safe environment and allows addressing human factors that are pivotal in safely managing the critically ill child. However, multidisciplinary simulation in our paediatric unit has also facilitated discussion about clinical governance issues within the wider institution. <h3>Aims</h3> Does multidisciplinary simulation program in paediatrics address clinical governance issues? <h3>Methods</h3> Over a four month period ad hoc in house multidisciplinary simulation sessions involving medical and nursing staff of all levels from the paediatric, anaesthetic, radiology and emergency medicine department were conducted. The simulation sessions were held on paediatric wards and in the emergency department. Faculty members were resuscitation officers, paediatricians, anaesthetists and nurses with experience in conducting simulation. The sessions lasted 20–25 min; followed by debrief for another 20 min. Immediate feedback on the simulation sessions and learning points was obtained. The quality, the usefulness and the conduct of the simulation were evaluated in a feedback form. <h3>Results</h3> In total, thirteen simulation sessions were held over a four month period and there were an average of 11 attendees per session. During immediate discussions areas of concern were identified. These included clinicians’ performance, human factors and clinical governance issues. Governance risks included inadequate resuscitation equipment and emergency protocol folder, access to emergency lifts, and the quality of emergency activation system. <h3>Conclusions</h3> Multidisciplinary simulation sessions are an important tool in addressing human factors that are crucial to successfully managing the critically ill patient. Multidisciplinary paediatric simulation has been vital in identifying and addressing clinical governance issues such as above. Subsequently, these areas of improvement were escalated to the divisional management team and appropriate steps were taken to address them and minimise the risk to sick children.
FLAW CHARACTERIZATION BY ULTRASONIC FREQUENCY ANALYSIS (1971)

A NEW METHOD WAS DEVELOPED FOR THE CHARACTERIZATION (DETERMINATION OF THE SIZE AND ORIENTATION) OF A REFLECTOR BY ULTRASONIC SPECTRAL ANALYSIS. THIS TECHNIQUE CAN BE USED TO DETERMINE NONDESTRUCTIVELY THE NATURE OF FLAWS DETECTED IN A MATERIAL BY MEANS OF ULTRASONIC EXAMINATION. IT IS SHOWN THAT IT IS FEASIBLE TO CHARACTERIZE A FLAW BY THIS TECHNIQUE IN SPITE OF ITS COMPOSITION (I.E., CRACK, VOID, OR INCLUSION) OR SHAPE AND WITHOUT THE NEED FOR A CALIBRATION STANDARD. THIS TECHNIQUE IS FREE OF SEVERAL LIMITATIONS INHERENT IN TECHNIQUES BASED ON AMPLITUDE. THE RESULTS PRESENTED HERE ARE BASED ON A SERIES OF REFLECTION EXPERIMENTS IN WHICH THE ENDS OF SOLID RODS IMMERSED IN WATER AND MACHINED DISCONTINUITIES IN METAL SAMPLES WERE USED AS REFLECTORS. BROAD-BAND ULTRASONIC PULSES WERE ANALYZED AFTER REFLECTION FROM THE INTERFACE OF INTEREST. A PHYSICAL AND ANALYTICAL MODEL WAS DEVELOPED BASED ON AN INTERFERENCE MECHANISM THAT RESULTS FROM THE SUPERPOSITION OF SPHERICAL WAVELETS EMITTED FROM OPPOSING EXTREMES OF THE REFLECTOR. THIS MODEL EXPLAINS VERY WELL THE EXPERIMENTALLY OBSERVED SPECTRA VARIATIONS IN TERMS OF SIZE AND THREE-DIMENSIONAL ANGULAR ORIENTATION OF THE REFLECTOR, DISTANCE BETWEEN THE TRANSDUCER AND REFLECTOR, AND DISPLACEMENT OF THE REFLECTOR FROM THE AXIS OF THE TRANSDUCER FOR A FLAT REFLECTOR OF ANY COMPOSITION. BASED ON THIS TECHNIQUE, A DETAILED PROCEDURE CAN BE OUTLINED FOR CHARACTERIZING A RANDOMLY ORIENTED NATURAL FLAW IN A PLATE. THE FEASIBILITY AND PRACTICALITY OF USING THIS TECHNIQUE TO TEST VARIOUS MATERIALS AND IN AUTOMATED TESTING SYSTEMS WERE CONSIDERED. /ME/
ANCA-associated scleritis: impact of ANCA on presentation, response to therapy and outcome (2023)

Isolated ANCA-associated scleritis is mostly anterior scleritis with a higher risk of scleromalacia than ANCA-negative idiopathic scleritis and is more often difficult to treat. One-third of patients with PR3- or MPO-ANCA scleritis progressed to systemic AAV.
A New Stereoselective Method for the Preparation of Allylic Alcohols (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTA New Stereoselective Method for the Preparation of Allylic AlcoholsEric Oblinger and John MontgomeryView Author Information Department of Chemistry, Wayne State University Detroit, Michigan 48202-3489 Cite this: J. Am. Chem. Soc. 1997, 119, 38, 9065–9066Publication Date (Web):September 24, 1997Publication History Received11 June 1997Published online24 September 1997Published inissue 1 September 1997https://pubs.acs.org/doi/10.1021/ja9719182https://doi.org/10.1021/ja9719182rapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views5231Altmetric-Citations237LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Alcohols,Aldehydes,Cyclization,Hydrocarbons,Molecular structure Get e-Alerts
Metal powder composite based on 316L stainless steel bimodal powder (2019)

Metal powder composites for Powder injection molding (PIM) technology have been investigated. 316L stainless steel bimodal powder, obtained by electric explosion of the wire and multicomponent binder comprising PMMA, PE-LD and Viscowax were used to obtain feedstocks. The effect of PMMA content in the binder on the properties of feedstocks and sintered parts has been studied. As the PMMA content increases, the molding temperature of the parts rises from 140 to 200°C, the strength of the “green” and “brow” parts increases as well. The optimal PMMA content in the binder has been found to be 15–20 vol %. “Brown” samples sintered in vacuum at 1300°C exhibit shrinkage up to 23% and the samples density reaches 0.98 TD. Samples of feedstocks were characterized by TEM, SEM, DSC-TG methods.
The role of dopamine in motor symptoms in the R6/2 transgenic mouse model of Huntington's disease (2002)

In both Huntington's disease (HD) patients and genetic mouse models of HD, there is a pre-symptomatic loss of dopamine (DA) receptors, suggesting that dysfunctional dopaminergic neurotransmission may be involved in early HD presentation. However, the role of DA in HD symptoms is not fully understood. In this study, we examined the possibility that dysfunctional dopaminergic neurotransmission contributes to the progressive decline in motor function of a transgenic mouse model of HD (R6/2 line). We found that R6/2 mice display an age-dependent abnormal behavioural response to (+)-methamphetamine (METH) and a dose-dependent increase in sensitivity to METH toxicity compared with wild-type (WT) mice. R6/2 mice also showed an attenuated response to cocaine, indicating that DA release may be compromised. Striatal DA levels were reduced in R6/2 mice by 9 weeks of age. Replacement of DA by chronic treatment with laevodopa (L-DOPA, administered as Sinemet) caused short-term improvements in activity and rearing behaviour, and abolished abnormal spontaneous hindlimb grooming. However, long-term treatment with L-DOPA had deleterious effects on survival and rotarod performance of R6/2 mice. These results suggest that dysfunctional DA neurotransmission contributes to phenotype development in R6/2 mice and thus also may be important in symptom progression in HD.
Gulf Offshore Satellite Application Project (1998)

The Gulf Offshore Satellite Applications Project (GOSAP) was designed to evaluate remote sensing systems such as RADARSAT and SAR and their use in petroleum, marine and environmental industries. The project`s goal is to detect oil seeps and spills in the marine environment and to determine the influence of sea temperature, geological, geochemical and biological factors on natural seep rates. GOSAP and the RADARSAT Application Development and Research Opportunity (ADRO) program acquired the first RADARSAT images over a Gulf of Mexico test site and observed spills as well as natural oil slicks. Operational criteria for RADARSAT commercial products for these applications were also determined, and special processing problems were resolved.
A simple pipeline for cell cycle kinetic studies in the root apical meristem (2022)

Root system architecture ultimately depends on precise signaling between different cells and tissues in the root apical meristem (RAM) and integration with environmental cues. This study describes a simple pipeline to simultaneously determine cellular parameters, nucleus geometry, and cell cycle kinetics in the RAM. The method uses marker-free techniques for nucleus and cell boundary detection, and 5-ethynyl-2'-deoxyuridine (EdU) staining for DNA replication quantification. Based on this approach, we characterized differences in cell volume, nucleus volume, and nucleus shape across different domains of the Arabidopsis RAM. We found that DNA replication patterns were cell layer and region dependent. G2 phase duration, which varied from 3.5 h in the pericycle to more than 4.5 h in the epidermis, was found to be associated with some features of nucleus geometry. Endocycle duration was determined as the time required to achieve 100% EdU-positive cells in the elongation zone and, as such, it was estimated to be in the region of 5 h for the epidermis and cortex. This experimental pipeline could be used to precisely map cell cycle duration in the RAM of mutants and in response to environmental stress in several plant species without the need for introgressing molecular cell cycle markers.
Multi-fragment effects on the GPU using the k -buffer (2007)

Many interactive rendering algorithms require operations on multiple fragments (i.e., ray intersections) at the same pixel location: however, current Graphics Processing Units (GPUs) capture only a single fragment per pixel. Example effects include transparency, translucency, constructive solid geometry, depth-of-field, direct volume rendering, and isosurface visualization. With current GPUs, programmers implement these effects using multiple passes over the scene geometry, often substantially limiting performance. This paper introduces a generalization of the Z-buffer, called the k-buffer, that makes it possible to efficiently implement such algorithms with only a single geometry pass, yet requires only a small, fixed amount of additional memory. The k-buffer uses framebuffer memory as a read-modify-write (RMW) pool of k entries whose use is programmatically defined by a small k-buffer program. We present two proposals for adding k-buffer support to future GPUs and demonstrate numerous multiple-fragment, single-pass graphics algorithms running on both a software-simulated k-buffer and a k-buffer implemented with current GPUs. The goal of this work is to demonstrate the large number of graphics algorithms that the k-buffer enables and that the efficiency is superior to current multipass approaches.
Intestinal Monocyte-Derived Macrophages Control Commensal-Specific Th17 Responses (2015)

Generation of different CD4 T cell responses to commensal and pathogenic bacteria is crucial for maintaining a healthy gut environment, but the associated cellular mechanisms are poorly understood. Dendritic cells (DCs) and macrophages (Mfs) integrate microbial signals and direct adaptive immunity. Although the role of DCs in initiating T cell responses is well appreciated, how Mfs contribute to the generation of CD4 T cell responses to intestinal microbes is unclear. Th17 cells are critical for mucosal immune protection and at steady state are induced by commensal bacteria, such as segmented filamentous bacteria (SFB). Here, we examined the roles of mucosal DCs and Mfs in Th17 induction by SFB in vivo. We show that Mfs, and not conventional CD103(+) DCs, are essential for the generation of SFB-specific Th17 responses. Thus, Mfs drive mucosal T cell responses to certain commensal bacteria.
Deformed Fermi Surface Theory of Magneto-Acoustic Anomaly in Modulated Quantum Hall Systems Near $\nu=1/2$ Hall Systems Near $\nu =1/2$ (1998)

We introduce a new generic model of a deformed Composite Fermion-Fermi Surface (CF-FS) for the Fractional Quantum Hall Effect near $\nu=1/2$ in the presence of a periodic density modulation. Our model permits us to explain the recent surface acoustic wave observations of anisotropic anomalies[R.L Willett et al,PRL vol78,4478 (1997);J.H.Smet et al, PRL vol 80,4538 (1998)] in sound velocity and attenuation--appearance of peaks and anisotropy-- which originate from contributions to the conductivity tensor due to regions of the CF-FS which are flattened by the applied modulation. The calculated magnetic field and wave vector dependence of the CF conductivity, velocity shift, and attenuation agree with experiments.
Clinical and radiological characteristics of metastatic prostate cancer (mPCa) patients (pts) with liver metastases (LM) and association with overall survival (OS). (2016)

5043 Background: The diagnosis (Dx) of LM in PCa pts carries a poor prognosis and its incidence is increasing. We conducted a retrospective analysis to identify clinical and radiological factors associated with OS in these pts. Methods: Pts with computed tomography (CT) radiologically confirmed LM referred to our institution between June/2003 and May/2015 were selected for this analysis. Clinical data were retrospectively collected and imaging performed at the time of Dx of LM was assessed by a radiologist. OS was measured from LM diagnosis until death or last follow-up. Descriptive summaries and Kaplan-Meier estimates were used to explore the data. The association of radiological features at the time of LM Dx and other known prognostic factors with OS were evaluated through univariate (UV) and multivariate (MV) Cox regression analyses. Results: We identified 126 mPCa pts with LM from a total of 632 pts (19.9%) of which 122 were evaluable. Four pts were excluded due to lack of adequate imaging. We observed 110 deaths (90.2%) and median OS time from LM diagnosis was 7.2 months (mo) (3.4-13.3 mo). In the MV, the onset of LM in relation to castration resistant (CR) status (p = 0.003), the ratio neutrophils/lymphocytes (NLR) (p = 0.005) and the size of the largest lesion (LL) (p = 0.018) remained significant. Conclusions: These data show the association of NLR with OS in this pts population and suggest other potential prognostic variables in mPCa pts with LM. UV MV N HR 95% CI p-value N HR 95% CI p-value Time being CR No CR or < 12mo 32 1.0 < 0.001 21 1 0.003 12-36mo 42 2.9 1.8 4.8 39 2.8 1.5 5.4 > 36mo 48 2.4 1.4 4.0 46 1.3 0.7 2.6 Radiological pattern < = 3 L and LL > 25 mm OR 4-10 L and LL > 50 mm 25 1.0 0.01 19 1.0 0.079 < = 3 L and LL < 25 mm OR 4-10 L and LL 25-50 mm 30 1.5 0.9 2.8 25 1.6 0.6 3.9 4-10 L and LL < 25 mm OR > 10 L 67 2.2 1.3 3.6 62 2.5 1.0 5.9 Largest L, mm 122 1.0 1.0 1.0 0.727 106 1.0 1.0 1.0 0.018 Smallest L, mm 122 1.0 1.0 1.0 0.156 106 1.0 1.0 1.1 0.488 Bone mets 0-4 42 1.0 0.9 3.0 < 0.001 32 1.0 0.052 5-20 21 1.7 2.6 6.9 18 2.1 1.0 4.6 > 20 59 4.3 56 2.2 1.1 4.4 Lung mets No 94 1.0 0.318 85 1.0 0.981 Yes 26 0.8 0.5 1.3 21 1.0 0.6 1.8 NLR 106 1.0 1.0 1.1 0.155 106 1.1 1.0 1.1 0.005