gebhart/patrepeval huggingface dataset:
85% endurance error reduction and data-retention lifetime enhancement by changing the reset voltage in 40 nm TaO X -based ReRAM (2020)

Abstract This paper proposes a changing reset voltage technique for 40 nm TaO X -based resistive random access memories (ReRAM). In the proposed technique, reset voltage ( V RESET ) changes at high endurance such as 10 4 set/reset cycles. The changing reset voltage technique decreases the measured total bit-error rate (BER) of both the low resistance state (LRS) and high resistance state (HRS) by 85%, compared with conventional fixed reset voltage. In addition, the current difference between LRS and HRS at probability = 50% (window) increases by 57% with the proposed technique, which increases the read margin between set and reset. Moreover, by decreasing the tail bits and expanding the read margin, the data-retention lifetime is increased. As a result, the changing reset voltage technique is recommended for high endurance and long data retention lifetime. Finally, this paper proposes a physical model of the proposed technique.
Sex- and Age-Based Disparities in Public Access Defibrillation, Bystander Cardiopulmonary Resuscitation, and Neurological Outcome in Cardiac Arrest (2023)

Results of this study suggest a pattern of significant sex- and age-based differences in bystander CPR, public access defibrillation, and neurological outcomes in Japan. Improvement in neurological outcomes in patients with OHCA, especially younger females, was associated with increased use of public access defibrillation and bystander CPR.
Streaming Current Based Microtubular Enzymatic Sensor for Self‐Powered Detection of Urea (2018)

Abstract The emergence of microfluidic techniques coupled with flow‐induced electrification has advanced the development of innovative self‐powered sensors. However, selective detection of target substances using these sensors is extremely challenging, owing to the lack of recognition elements in the flow pathway. To overcome this, catalytic enzymes are immobilized on the microfluidic channel and the concentration of targets is measured via monitoring the streaming current. As an example, a urease equipped self‐powered microtubular sensor is developed to selectively detect urea, a physiologically and industrially important molecule. The urease catalyzes the hydrolysis of urea into ions, increasing the pH of the fluid, which serves as the basis of the sensing mechanism. Remarkably, high sensitivity, wide detection range, short response time, and superior selectivity are reported for urinary urea detection. The accuracy and reliability of sensing in artificial urine are validated with the standard spectrophotometric method. The microtubular sensor features facile fabrication and operation and circumvents the need for sophisticated peripherals, highlighting its enormous potential in chemical and biomedical applications, such as pollutant detection, food quality assessment, disease diagnosis, and point‐of‐care testing.
Advanced fault isolation technique using electro-optical terahertz pulse reflectometry (2012)

Electro-optical terahertz pulse reflectometry (EOTPR) was introduced recently to isolate faults in advanced IC packages. The EOTPR system provides 10 μm in distance accuracy that can be used to localize package-level open and short failures non-destructively. In this paper, an EOTPR system was used to determine the location of open and short failures and to identify impedance variations in a series of package substrates. The experimental results demonstrate the higher accuracy of the EOTPR system in determining the distance to defect compared to traditional time-domain reflectometry systems. Finally, physical failure analysis was used to verify the accuracy of the EOTPR results.
Introduction to Content Interventions (2015)

This chapter considers the content of thinking, which means we will be considering meaning. It considers how the major techniques of cognitive therapy can be used for working with Christian people, using content from the teaching of Jesus. The actual wording of the proposition(s) or for any given instance can be the result of collaboration between therapist and patient. Work on the implicational content of beliefs is done by various means. Most common are experiential approaches, such as setting up an experience in real life; dramatic approaches, such as acting out the appropriate material; imaginal imagery based approaches; graphic imagery; poetry; cinematic presentation; and music. At the beginning of therapy many clients will have conceptions of Jesus that are overly pious, or idealised, and may even have difficulty imagining them as Jesus because they might see that as inappropriate.
Entrectinib in children and young adults with solid or primary CNS tumors harboring NTRK, ROS1, or ALK aberrations (STARTRK-NG) (2022)

Entrectinib resulted in rapid and durable responses in pediatric patients with solid tumors harboring NTRK1/2/3 or ROS1 fusions.
Long noncoding RNA MEG3 activates neuronal necroptosis in Alzheimer’s disease (2022)

Abstract/Summary Neuronal cell loss is a defining feature of Alzheimer’s disease (AD), but it remains unclear how neurons die and how this relates to other defining characteristics of the disease 1 . Existing in vivo AD models only partially recapitulate the neuropathology of AD with very mild or no neuronal cell loss. Here we demonstrate that human neurons xenografted in mouse brain exposed to amyloid pathology develop sarkosyl-insoluble tau filaments, positive Gallyas silver staining, release phosphorylated tau (P-tau181) into the blood, and display considerable neuronal cell loss, providing a model for the induction of full Tau pathology by simple exposure to amyloid pathology in AD. The alterations are specific to human neurons and contrast with the mild effects exhibited in mouse neurons. A core transcriptional program in the human neurons is characterized by strong upregulation of MEG3, a neuron-specific long noncoding RNA . MEG3 is also strongly upregulated in neurons from AD patients in situ . MEG3 expression alone is sufficient to induce necroptosis in human neurons in vitro . Orally administered small molecule receptor-interacting protein (RIP) kinase -1 and -3 inhibitors rescued the neuronal cell loss in this novel AD model. Thus, xenografted human neurons are uniquely sensitive to amyloid pathology, recapitulate all the defining neuropathological features of AD, and ultimately die by necroptosis.
Analysis and visualization of temporal changes in bloggers' activities and interests (2012)

Social media such as blogs and microblogs enable users to easily and rapidly publish information on their personal activities and interests. They are considered to provide valuable information from the viewpoints of sociology, linguistics, and marketing. This paper proposes a novel system for analyzing temporal changes in the activities and interests of bloggers through a 3D visualization of phrase dependency structures in sentences. We first extract events that represent bloggers' activities and interests through analyzing the phrase dependencies of sentences in a blog archive. We roughly categorize the retrieved events according to the thematic roles (such as the experiencer, agent, and location) of the noun within the events, and then store them in a dependency database so that we can retrieve events that involve a given topic. Second, we present a 3D visualization framework for exploring temporal changes in events related to a topic. Our framework enables users to find events about a topic that appear within a specific timing, and drill down details of the events. It also enables users to compare events with different timings and/or on multiple topics. Moreover, it allows them to observe an overview of temporal changes in sets of events, and long-term changes in the frequency of events to assist users in finding trends. We implement the proposed system on our own five-year blog archive that focused on Japanese, and we report the usefulness of our system by using various examples.
Schedule‐dependent interaction of doxorubicin, paclitaxel and gemcitabine in human breast cancer cell lines (1999)

We showed previously that a sequential treatment with doxorubicin (4 hr) followed by paclitaxel (24 hr) (Dox→Pacl) induces a synergistic cytotoxic effect in the BRC-230 breast cancer cell line and in human primary breast cancer cultures. The validity of this experimental finding was confirmed in a clinical phase I/II study on advanced breast cancer patients. To improve the cytotoxic effect obtained by the Dox→Pacl sequence, we analyzed the effect of adding gemcitabine (Gem) to the Dox→Pacl sequence in a preclinical study. Our study was performed on BRC-230 and MCF-7 cell lines, and cytotoxic activity was evaluated by the sulforhodamine B assay and the type of drug interaction by Drewinko's test. When Gem (0.01 μg/ml for 24 hr) was given immediately or 24 hr after Dox→Pacl, an antagonistic cytotoxic effect was observed. Conversely, a synergistic effect was found when Gem was given 48 hr after Dox→Pacl. From results of flow cytometric analysis, the synergistic effect was attributed to cell cycle perturbation. Cells were arrested in G2-M (95% in treated vs. 21% in control samples) 24 hr after Dox→Pacl treatment. The block progressively recovered thereafter, and after a further 24 hr, at the time of Gem treatment, the cells progressed into the G1-S phase boundary (the cell cycle phase susceptible to the cytocidal effect of the drug). Our findings suggest that the interactions of Dox, Pacl and Gem are highly schedule- and time-dependent and should be taken into consideration in the planning of clinical protocols. Int. J. Cancer 80:413–416, 1999. © 1999 Wiley-Liss, Inc.
Research progress on potential liver toxic components in traditional Chinese medicine (2016)

In recent years, the proportion of traditional Chinese medicine in scientific research and its clinical use increased gradually. The research result also becomes more and more valuable, but in the process of using traditional Chinese medicine, it also needs to pay more attention. With the gradual deepening of the toxicity of traditional Chinese medicine, some traditional Chinese medicines have also been found to have the potential toxicity, with the exception of some traditional toxicity Chinese medicine. Traditional Chinese medicine in the growth, processing, processing, transportation and other aspects of pollution or deterioration will also cause the side effects to the body. Clinical practice should be based on the theory of traditional Chinese medicine to guide rational drug use and follow the symptomatic medication, the principle of proper compatibility. The constitution of the patients are different, except for a few varieties of traditional Chinese medicines are natural herbs with hepatotoxicity, liver toxicity of most of the traditional Chinese medicine has idiosyncratic features. The liver plays an important role in drug metabolism. It is easy to be damaged by drugs. Therefore, the study of traditional Chinese medicine potential liver toxicity and its toxic components has become one of the basic areas of traditional Chinese medicine research. Based on the review of the literatures, this paper summarizes the clinical classification of liver toxicity, the pathogenesis of target cell injury, and systematically summarizes the mechanism of liver toxicity and toxic mechanism of traditional Chinese medicine. This paper provided ideas for the study of potential liver toxicity of traditional Chinese medicine and protection for clinical safety of traditional Chinese medicine.
Facile stereoselective synthesis of (23S,25R)-1.alpha.,25-dihydroxyvitamin D3 26,23-lactone, a major metabolite of 1.alpha.,25-dihydroxyvitamin D3 (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFacile stereoselective synthesis of (23S,25R)-1.alpha.,25-dihydroxyvitamin D3 26,23-lactone, a major metabolite of 1.alpha.,25-dihydroxyvitamin D3Keiko Yamamoto, Masato Shimizu, Sachiko Yamada, Suguru Iwata, and Osamu HoshinoCite this: J. Org. Chem. 1992, 57, 1, 33–39Publication Date (Print):January 1, 1992Publication History Published online1 May 2002Published inissue 1 January 1992https://pubs.acs.org/doi/10.1021/jo00027a010https://doi.org/10.1021/jo00027a010research-articleACS PublicationsRequest reuse permissionsArticle Views393Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Preparation study on large-scale PV system with pumped storage systems (2013)

The purpose of this paper is to study large-scale PV system with pumped storage systems (PSS). It is proposed a new method for PSS to store the electric power from PV system in the daytime and discharge in the nighttime as base power supply. Moreover, it should be concerned with the installing position of PSS, the capacity of PSS, the transmission capacity, the land and personnel cost, and the base power supply. The results indicate that PSS has possibility to be electric storage system in large-scale PV system. It can be used as base power supply to satisfy demand and to reduce or stop the output of nuclear or fuel oil electricity stations. It is possible that use base power supply from PV power instead of electricity from nuclear or fuel oil electric power stations.
Directionality of Electron Transfer in Type I Reaction Center Proteins: High-Frequency EPR Study of PS I with Removed Iron–Sulfur Centers (2015)

A key step of photosynthetic solar energy conversion involves rapid light-induced sequential electron-transfer steps that result in the formation of a stabilized charge-separated state. These primary reactions take place in large integral membrane reaction center (RC) proteins, wherein a series of donor/acceptor cofactors are specifically positioned for efficient electron transfer. RCs can be divided in two classes, Type I and Type II and examples of both types, photosystem I (PS I) and photosystem II (PS II), are involved in the oxygenic photosynthesis of higher plants, cyanobacteria, and algae. High-resolution X-ray crystal structures reveal that PS I and PS II contain two nearly symmetric branches of redox cofactors, termed the A and B branches. While unidirectional ET along the A branch in Type II RCs is well established, there is still a debate of whether primary photochemistry in Type I RCs is unidirectional along the A branch or bidirectional proceeding down both of the A and B branches. Light-induced electron transfer through the B branch has been observed in genetically modified PS I and in native PS I pretreated with strong reducing conditions to reduce three [4Fe-4S] clusters, the terminal electron acceptors of PS I; however, the extent of asymmetry of ET along both cofactor branches remains an open question. To prove that bidirectional ET in PS I is not simply an artifact of a reducing environment or genetic modification and to determine the degree of PS I ET asymmetry, we have examined biochemically modified Synechococcus leopoliensis PS I RCs, wherein the [4Fe-4S] clusters FX, FA, and FB have been removed to prevent secondary ET from phylloquinones (A1A/A1B) to FX. For these Fe-removed proteins, we observe that ET along both the A and B branches occurs with a ratio close to 1. Together with previously reported data, the concomitant structural and kinetic information obtained with HF EPR unambiguously proves the bidirectional nature of ET in PS I over a broad temperature range.
Preliminary analysis of laser-pulse-induced pressure variation for immersion lithography (2004)

We describe an assessment of the pressure rise that may be induced by the short-duration but high-power pulses associated with the immersion lithography exposure process. A conservative model provides an upper bound on the pressure rise related to the expansion of the fluid near the wafer due to rapid heating. This rapid heating process is simulated as a constant heat flux from the substrate. The resulting temperature rise causes a change in pressure that propagates into the fluid at the speed of sound. The net change in the mass of the fluid contained within the pressure wavefront must be zero. This continuity requirement allows an estimate of the pressure rise and its penetration depth into the gap. For the nominal conditions associated with 193-nm immersion lithography, the model predicts that the pressure near the wafer surface may rise by as much as 7.3 kPa during the laser pulse. At the end of the laser pulse, this pressure rise will extend nominally 75 μm into the gap. Following the laser pulse, this pressure rise will rapidly decay as the pressure wavefront continues to propagate across the gap and eventually out of the under-lens region.
Cytokine profiles and diagnoses in elderly, hospitalized psychiatric patients (2018)

Retrospectively registered in the ISRCTN registry study, with study ID ISRCTN71047363 .
Orthogonal high-density mapping with ventricular tachycardia isthmus analysis vs. pure substrate ventricular tachycardia ablation: A case–control study (2022)

The use of a method based on extensive mapping with the HD Grid Mapping Catheter and VT isthmus analysis allows better discrimination of the arrhythmic substrate and could be associated with a greater decrease in VT burden.
[Reference guide for adult chronic neutropenia]. (2019)

Chronic neutropenia is a rare hematological entity characterized by isolated neutropenia without anemia or thrombocytopenia. The diagnostic criteria and classification of chronic neutropenia have been more elusive in adult cases than pediatric cases. We herein propose the Reference Guide for Adult Chronic Neutropenia. In this guide, diagnosis of chronic neutropenia is based on recurrent or continuous neutropenia defined by absolute neutrophil count (ANC) less than 1,500/µl for over three or more months. Severity of chronic neutropenia is defined as follows: severe, ANC <500/µl; moderate, ANC between 500 and 1,000/µl; mild, ANC between 1,000 and 1,500/µl. In this guide, adult chronic neutropenia is classified into several types including autoimmune neutropenia, cyclic neutropenia, chronic neutropenia with T cell clone, and chronic idiopathic neutropenia with or without family history, and their clinical characteristics are described. Together with antibiotics, granulocyte colony-stimulating factors (G-CSFs) constitute the first-line treatment for adult chronic neutropenia patients at time of bacterial infections. Prophylactic use of G-CSFs or antibiotics is recommended only in selected clinical settings in severe cases.
Integrated structure-function dataset reveals key mechanisms underlying photochromic fluorescent proteins (2020)

Abstract Photochromic fluorescent proteins have become versatile tools in the life sciences, though our understanding of their structure-function relation is limited. Starting from a single scaffold, we have developed a range of 27 photochromic fluorescent proteins that cover a broad range of spectroscopic properties, yet differ only in one or two mutations. We also determined 43 different crystal structures of these mutants. Correlation and principal component analysis of the spectroscopic and structural properties confirmed the complex relationship between structure and spectroscopy, suggesting that the observed variability does not arise from a limited number of mechanisms, but also allowed us to identify consistent trends and to relate these to the spatial organization around the chromophore. We find that particular changes in spectroscopic properties can come about through multiple different underlying mechanisms, of which the polarity of the chromophore environment and hydrogen bonding of the chromophore are key modulators. Furthermore, some spectroscopic parameters, such as the photochromism, appear to be largely determined by a single or a few structural properties, while other parameters, such as the absorption maximum, do not allow a clear identification of a single cause. We also highlight the role of water molecules close to the chromophore in influencing photochromism. We anticipate that our dataset can open opportunities for the development and evaluation of new and existing protein engineering methods.
Cost-effectiveness of replacing versus discarding the nail in children with nail bed injury (2023)

Lay Summary Every year in the UK, around 10 000 children need to have operations to mend injuries to the bed of their fingernails. Currently, most children have their fingernail placed back on the injured nail bed after the operation. The NINJA trial found that children were slightly less likely to have an infection if the nail was thrown away rather than being put back, but the difference between groups was small and could have be due to chance. This study looked at whether replacing the nail is cost-effective compared with throwing it away. Using data from the NINJA trial, we compared costs, healthcare use, and quality of life and assessed the cost-effectiveness of replacing the nail. It was found that throwing the nail away after surgery would save the National Health Service (NHS) £75 (€85) per operation compared with placing the nail back on the nail bed. Changing clinical practice could save the NHS in England £720 000 (€819 000) per year.
The New Hong Kong Cinema and the Déjà Disparu (1994)

For about a decade now, it has become increasingly apparent that a new Hong Kong cinema has been emerging. It is both a popular cinema and a cinema of auteurs, with directors like Ann Hui, Tsui Hark, Allen Fong, John Woo, Stanley Kwan, and Wong Rar-wei gaining not only local acclaim but a certain measure of international recognition as well in the form of awards at international film festivals. The emergence of this new cinema can be roughly dated; two dates are significant, though in very different ways. The first occurs around 1979, which is when a new generation of Hong Kong-born filmmakers, educated in film schools abroad and with no direct ties with either China or Taiwan, turn to filmmaking after a period of apprenticeship in local television. The result is a cinema that in terms of technical competence and thematic richness represents a qualitative leap forward from what went before. Three films released in 1982 exemplify this moment: Tsui Hark' s Zu: Warriors from the Magic Mountain , a kung fu film distinguished by its brilliant mastery of special effects; Ann Hui's Boat People , about Vietnamese refugees, a courageous use of cinema to deal with pressing social and political issues; and Allen Fong's Father and Son , with its quasi-autobiographical story about growing up in working-class Hong Kong, where everyday life is presented by means of a sophisticated film language. The second date is, I believe, even more consequential for Hong Kong cinema 1984, the year of Thatcher's visit to China which culminated in the Joint Declaration returning Hong Kong