gebhart/patrepeval huggingface dataset:
Performance evaluation of SISO, SIMO and MIMO antenna systems for car-to-car communications in urban environments (2009)

This paper evaluates single and multiple antenna systems in realistic car-to-car communication channels. With a three-dimensional ray-tracing simulation tool the narrow-band channel characteristics are determined for various antenna positions and numbers of antennas. The results clearly show the advantage of multiple antenna systems. Suitable antenna positions are determined that allow for optimizing the signal-to-noise ratio and the channel capacity.
Magneto‐Thermal Metrics Can Mirror the Long‐Term Intracellular Fate of Magneto‐Plasmonic Nanohybrids and Reveal the Remarkable Shielding Effect of Gold (2017)

Multifunctional nanoparticles such as magneto‐plasmonic nanohybrids are rising theranostic agents. However, little is yet known of their fate within the cellular environment. In order to reach an understanding of their biotransformations, reliable metrics for tracking and quantification of such materials properties during their intracellular journey are needed. In this study, their long‐term (one month) intracellular fate is followed within stem‐cell spheroids used as tissue replicas. A set of magnetic (magnetization) and thermal (magnetic hyperthermia, photothermia) metrics is implemented to provide reliable insightsinto the intracellular status. It shows that biodegradation is modulated by the morphology and thickness of the gold shell. First a massive dissolution of the iron oxide core (nanoflower‐like) is observed, starting with dissociation of the multigrain structure. Second, it is demonstrated that an uninterrupted gold shell can preserve the magnetic core and properties (particularly magnetic hyperthermia). In addition to the magnetic and thermal metrics, intracellular high‐resolution chemical nanocartography evidences the gradual degradation of the magnetic cores. It also shows different transformation scenarios, from the release of small gold seeds when the magnetic core is dissolved (interesting for long‐term elimination) to the protection of the magnetic core (interesting for long‐term therapeutic applicability).
Outbreaks of Filovirus Hemorrhagic Fever: Time to Refocus on the Patient (2007)

In the 40 years since the recognition of filoviruses as agents of lethal human disease, there have been no specific advances in antiviral therapies or vaccines and few clinical studies on the efficacy of supportive care. On 20 September 2006, experts from 14 countries representing 68 institutions integrally involved in the response to outbreaks of filovirus hemorrhagic fever gathered at the National Microbiology Laboratory of the Public Health Agency of Canada in Winnipeg to discuss possible remedies for this grim situation, in a unique workshop entitled "Marburg and Ebola Hemorrhagic Fever: Feasibility of Prophylaxis and Therapy." A summary of the opportunities for and challenges to improving treatment of filovirus hemorrhagic fevers is presented here.
Carbohydrate-deficient transferrin is associated with insulin sensitivity in hypertensive men. (1994)

An elevated concentration of carbohydrate-deficient transferrin in serum (CDT) has been reported to indicate excessive ethanol consumption. However, in hypertensive men, we found low values for diagnostic sensitivity and specificity. Furthermore, in the individuals with high CDT values, the concentrations of serum triglycerides and blood glucose were low rather than high, indicating that factors related to insulin/glucose metabolism may be operative. The current study addresses this issue by examining 48 patients with treated hypertension and at least 1 of following: hypercholesterolemia, history of smoking, and diabetes mellitus. We determined serum CDT, fasting plasma insulin, and glucose disposal rate during hyperinsulinemic euglycemic clamp. Seven patients had elevated CDT concentrations. This group of patients had higher glucose disposal rates than the others (mean difference, 19 mumol/min.kg lean body mass; 95% confidence interval, 5-33 mumol/min.kg lean body mass; P = 0.0096), but did not differ in body mass index or alcohol intake. Serum CDT correlated positively with glucose disposal rate (r = 0.55; P = 0.0004) and negatively with fasting plasma insulin (r = -0.43; P = 0.0039). These relationships remained after exclusion of 8 patients with diabetes mellitus and adjustment for potentially confounding factors. We conclude that the serum CDT concentrations in our patients were associated with insulin sensitivity.
Knitting Performance of Wool Yarns: Instrumentation Studies 1 (1967)

The knitting performance of a yarn, in terms of the work T y required to knit the yarn into jersey fabric, is measured hy use of a sensitive torque transducer located on the driving shaft of an experimental knitting machine. Using this technique, the knitting per formances of a variety of worsted wool yarns are studied, and the effects of input tension, yarn/metal friction, yarn/yarn friction, twist level, and the WURLAN shrink-resist treatment on knitting performance are investigated. By the use of a mathematical analysis, the knitting behavior of a worsted yarn with changes in input tension is shown to be essentially similar to that predicted. Under normal commercial knitting conditions, T y is directly proportional to yarn/metal friction but independent of yarn/yarn friction. It is proposed that if the coefficient of yarn/metal friction ≤ 0.2, little trouble will be encountered in the knitting of wool yarns, and that the sometimes irregular appearance of knitted wool fabrics may be attributed to both spin ning irregularity and the magnitude of yarn/metal friction. The knitting performance of a multi-filament nylon yarn is also shown to be dependent on yarn/metal friction. The use of yarn feeding devices at the standard knit construction reduces T y at any input tension, confirming that higher knitting speeds, increased efficiencies, and more regular fabric are attainable. The effect of yarn/metal friction on knitting performance is substantially decreased by the use of positive feed. An increase in twist factor from 1.8 to 2.8 had little effect on T y , although slightly increased values are found for high- twist yarns. However, the WURLAN interfacial-polymerization wool shrink-resist treatment increased T y as much as 60% at normal input tensions. This effect seemed to be unrelated to measured changes in yarn/metal friction and yarn flexural rigidity, but could possibly be due to changes in yarn/yarn friction. Some interesting observations of the mechanical performance of knitting machinery are also reported in this paper.
Analysis of sensory system aspects of postural stability during quiet standing in adolescent idiopathic scoliosis patients (2018)

This implies that AIS patients use strategies to compensate for possible head position changes and spinal asymmetry caused by morphological deformations of the spine through vestibular and somatosensory systems. This could be interpreted that such compensation could help them maintain postural stability during quiet standing. The interpretation of CoP signal during quiet standing in AIS patients will improve our understanding of changes in physical exercise ability due to morphological deformity of the spine. This result is useful for evaluating postural stability before and after treatments (spinal fusion, bracing, rehabilitation, and so on).
Polymer Collapse (1981)

Machine learning (ML) is transforming all areas of science. The complex and time-consuming calculations in molecular simulations are particularly suitable for an ML revolution and have already been profoundly affected by the application of existing ML ...Read More
Visual research methods in fashion, Julia Gaimster, Oxford; New York: Berg Publishers, 2011. 292 p. ill. ISBN 9781847883810. $39.95 (paper). (2012)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Dead-end complex, lipid interactions and catalytic mechanism of microsomal glutathione transferase 1, an electron crystallography and mutagenesis investigation (2017)

Microsomal glutathione transferase 1 (MGST1) is a detoxification enzyme belonging to the Membrane Associated Proteins in Eicosanoid and Glutathione Metabolism (MAPEG) superfamily. Here we have used electron crystallography of two-dimensional crystals in order to determine an atomic model of rat MGST1 in a lipid environment. The model comprises 123 of the 155 amino acid residues, two structured phospholipid molecules, two aliphatic chains and one glutathione (GSH) molecule. The functional unit is a homotrimer centered on the crystallographic three-fold axes of the unit cell. The GSH substrate binds in an extended conformation at the interface between two subunits of the trimer supported by new in vitro mutagenesis data. Mutation of Arginine 130 to alanine resulted in complete loss of activity consistent with a role for Arginine 130 in stabilizing the strongly nucleophilic GSH thiolate required for catalysis. Based on the new model and an electron diffraction data set from crystals soaked with trinitrobenzene, that forms a dead-end Meisenheimer complex with GSH, a difference map was calculated. The map reveals side chain movements opening a cavity that defines the second substrate site.
A Generalized LinDistFlow Model for Power Flow Analysis (2021)

This paper proposes a new linear power flow model for distribution system with accurate voltage magnitude estimates. The new model can be seen as a generalization of LinDistFlow model to multiphase distribution system with generic network topology (radial or meshed) around arbitrary linearization point. We have shown that the approximation quality of the proposed model strictly dominates that of the fixed-point linearization (FPL) method, a popular linear power flow model for distribution system analysis, when both are linearized around zero injection point. Numerical examples using standard IEEE test feeders are provided to illustrate the effectiveness of the proposed model as well as the improvement in accuracy over existing methods when linearized around nonzero injection points.
Synthesis of some substituted guanidinopyrimidines and their structural assignment by 13C and 1H NMR (1982)

Abstract A series of substituted 2‐ and 4‐guanidinopyrimidines were prepared by reaction of halopyrimidines with guanidine; alkylamino and amino substituents were introduced by subsequent halogen replacement by primary amines or ammonia or the catalytic reduction of nitro groups. Structural assignments were made on the basis of 13 C and 1 H nmr. A guanidinopteridine and a bispyrimidinylguanidine were also synthesized. Some unsuccessful reactions illustrated the low nucleophilic reactivity and thermal instability of the guanidine group.
Autoradiographic detections of 111indium-labeled platelets in brain tissue sections. (1984)

Various techniques for detection of blood platelets in tissue section were evaluated in an incremental air embolism model of ischemia in order to further investigate the accumulation of platelets in brains subjected to cell-damaging ischemia. The experimental animals were dogs anesthetized with alpha-chloralose. A new autoradiographic technique was devised that allows precise localization of 111Indium-labeled platelets in brain sections. The technique is described in detail along with some effects of the label on platelet function and behavior. The technique can be performed in conjunction with 14C-iodoantipyrine autoradiographic measurement of blood flow without causing mutual interference or other forms of interaction. This permits the simultaneous investigation of local blood flow and deposition of platelets.
Incidence and risk factors for reactivation from resolved hepatitis B virus in rheumatoid arthritis patients treated with biological disease‐modifying antirheumatic drugs (2018)

HBV reactivation occurred in 4.6% of RA patients with resolved HBV during the treatment with bDMARDs and the absence of anti-HBs may be a risk factor for the reactivation of resolved HBV.
Enantioselective Construction of α‐Quaternary Cyclobutanones by Catalytic Asymmetric Allylic Alkylation (2013)

No strain, no gain! The first transition metal-catalyzed enantioselective α-alkylation of cyclobutanones is reported. This method employs palladium catalysis and an electron-deficient PHOX-type ligand to afford all-carbon α-quaternary cyclobutanones in good to excellent yields and enantioselectivities (see scheme). As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Highly constrained multiple-copy refinement of protein crystal structures (1997)

In the course of refining atomic protein structures, one often encounters difficulty with molecules that are unusually flexible or otherwise disordered. We approach the problem by combining two relatively recent developments: simultaneous refinement of multiple protein conformations and highly constrained refinement. A constrained Langevin dynamics refinement is tested on two proteins: neurotrophin-3 and glutamine synthetase. The method produces closer agreement between the calculated and observed scattering amplitudes than standard, single-copy, Gaussian atomic displacement parameter refinement. This is accomplished without significantly increasing the number of fitting parameters in the model. These results suggest that loop motion in proteins within a crystal lattice can be extensive and that it is poorly modeled by isotropic Gaussian distributions for each atom.
[Importance of cytogenetic investigations in canine leukemias]. (1997)

Like in man, in neoplastic haematopoietic diseases of the dog genetical changes can be detected cytogenetically. In this study, some cytogenetically characterized cases are presented and discussed against the background of comparable cases reported in the literature. In two out of three patients investigated, one or two extra copies of chromosome 1 were detected. Corresponding changes have also been described in two other cases in the literature.
Endovascular Treatment or Neurosurgical Clipping of Ruptured Intracranial Aneurysms (2010)

In this exploratory analysis, aneurysm coiling was associated with less angiographic vasospasm and delayed ischemic neurological deficit than surgical clipping, whereas no effect on cerebral infarction or clinical outcome was observed. Whether this is attributable to differences in baseline risk factors between clipped and coiled patients or a true difference cannot be proven here.
Excessive formation of hydroxyl radicals and aldehydic lipid peroxidation products in cultured skin fibroblasts from patients with complex I deficiency. (1997)

Previous studies suggest oxygen free radicals' involvement in the etiology of cardiomyopathy with cataracts. To investigate the role of free radicals in the pathogenesis of the cardiomyopathy with cataracts and complex I deficiency, fibroblasts from patients were assessed for hydroxyl radical formation and aldehydic lipid peroxidation products with and without redox active agents that increase free radicals. The rate of hydroxyl radical formation in patient cells was increased over 2-10-fold under basal conditions, and up to 20-fold after menadione or doxorubicin treatment compared with normal cells. We also found an overproduction of aldehydes in patient cells both under basal conditions and after treatment. Both hydroxyl radicals and toxic aldehydes such as hexanal, 4-hydroxynon-2-enal, and malondialdehyde were elevated in cells from patients with three types of complex I deficiency. In contrast, acyloins, the less toxic conjugated products of pyruvate and saturated aldehydes, were lower in the patient cells. Our data provide direct evidence for the first time that complex I deficiency is associated with excessive production of hydroxyl radicals and lipid peroxidation. The resultant damage may contribute to the early onset of cardiomyopathy and cataracts and death in early infancy in affected patients with this disease.
Socioeconomic impact of influenza on healthy children and their families (2003)

The findings of this study support a wider use of influenza vaccine in healthy children of all ages to reduce the socioeconomic burden of influenza on the community.
Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale (2014)

There has been a long-standing interest in the assessment of the neurobehavioral integrity of the newborn infant. The NICU Network Neurobehavioral Scale (NNNS) was developed as an assessment for the at-risk infant. These are infants who are at increased risk for poor developmental outcome because of insults during prenatal development, such as substance exposure or prematurity or factors such as poverty, poor nutrition or lack of prenatal care that can have adverse effects on the intrauterine environment and affect the developing fetus. The NNNS assesses the full range of infant neurobehavioral performance including neurological integrity, behavioral functioning, and signs of stress/abstinence. The NNNS is a noninvasive neonatal assessment tool with demonstrated validity as a predictor, not only of medical outcomes such as cerebral palsy diagnosis, neurological abnormalities, and diseases with risks to the brain, but also of developmental outcomes such as mental and motor functioning, behavior problems, school readiness, and IQ. The NNNS can identify infants at high risk for abnormal developmental outcome and is an important clinical tool that enables medical researchers and health practitioners to identify these infants and develop intervention programs to optimize the development of these infants as early as possible. The video shows the NNNS procedures, shows examples of normal and abnormal performance and the various clinical populations in which the exam can be used.
Home-based self-management for sedentary individuals with mild walking disability after stroke: protocol for a randomized pilot study (2023)

Abstract Background A Phase I study showed that is feasible to implement a home-based self-management program aimed at increasing physical activity in individuals after stroke with mild impairments in Brazil. The next step is to test this program against a control group in order to provide a power analysis for a fully-powered Phase III clinical trial. Methods A Phase II pilot randomized clinical trial with concealed allocation, blinded measurement, and intention-to-treat analyses will be carried out. The inclusion criteria will be: individuals who had suffered a stroke, in the acute or subacute phase, with mild impairments, sedentary, and with no significant language impairment. The individuals will be randomly allocated to the experimental or control group. The experimental group will receive 6 sessions of a home-based self-management program, based on behaviour change techniques, over 11 weeks. The control group will receive education about stroke, orientation regarding the importance of practicing physical activity after a stroke and usual care. A total of 24 participants will be recruited. The primary outcome will be physical activity, measured through steps taken per day by an activity monitor (Actigraph wGT3X-BT, Pensacola, FL, USA). Secondary outcomes will be cardiovascular risk (body mass index, waist circumference, and blood pressure), depressive symptoms (Geriatric Depression Scale), walking ability (6-Minute Walk Test and 10-Meter Walk Test), exercise self-efficacy (Self-Efficacy for Exercise scale), social participation (Stroke Impact Scale) and quality of life (EuroQual-5D). All outcomes will be measured at baseline (Week 0), post-intervention (Week 12), and follow-up (Week 24). This pilot clinical trial was registered online at Clinical Trials under number NCT05461976 in 4th April, 2022. Discussion If beneficial, this Phase II pilot randomized trial will provide data to plan a fully powered future Phase III clinical trial aimed at verifying the efficacy of this program to promote physical activity after stroke. Trial registration: Clinical Trials NCT05461976.
Convergent elevation trends in canopy chemical traits of tropical forests (2015)

The functional biogeography of tropical forests is expressed in foliar chemicals that are key physiologically based predictors of plant adaptation to changing environmental conditions including climate. However, understanding the degree to which environmental filters sort the canopy chemical characteristics of forest canopies remains a challenge. Here, we report on the elevation and soil-type dependence of forest canopy chemistry among 75 compositionally and environmentally distinct forests in nine regions, with a total of 7819 individual trees representing 3246 species collected, identified and assayed for foliar traits. We assessed whether there are consistent relationships between canopy chemical traits and both elevation and soil type, and evaluated the general role of phylogeny in mediating patterns of canopy traits within and across communities. Chemical trait variation and partitioning suggested a general model based on four interconnected findings. First, geographic variation at the soil-Order level, expressing broad changes in fertility, underpins major shifts in foliar phosphorus (P) and calcium (Ca). Second, elevation-dependent shifts in average community leaf dry mass per area (LMA), chlorophyll, and carbon allocation (including nonstructural carbohydrates) are most strongly correlated with changes in foliar Ca. Third, chemical diversity within communities is driven by differences between species rather than by plasticity within species. Finally, elevation- and soil-dependent changes in N, LMA and leaf carbon allocation are mediated by canopy compositional turnover, whereas foliar P and Ca are driven more by changes in site conditions than by phylogeny. Our findings have broad implications for understanding the global ecology of humid tropical forests, and their functional responses to changing climate.