gebhart/patrepeval huggingface dataset:
DNA Repair and Cell Cycle Biomarkers of Radiation Exposure and Inflammation Stress in Human Blood (2012)

DNA damage and repair are hallmarks of cellular responses to ionizing radiation. We hypothesized that monitoring the expression of DNA repair-associated genes would enhance the detection of individuals exposed to radiation versus other forms of physiological stress. We employed the human blood ex vivo radiation model to investigate the expression responses of DNA repair genes in repeated blood samples from healthy, non-smoking men and women exposed to 2 Gy of X-rays in the context of inflammation stress mimicked by the bacterial endotoxin lipopolysaccharide (LPS). Radiation exposure significantly modulated the transcript expression of 12 genes of 40 tested (2.2E-06<p<0.03), of which 8 showed no overlap between unirradiated and irradiated samples (CDKN1A, FDXR, BBC3, PCNA, GADD45a, XPC, POLH and DDB2). This panel demonstrated excellent dose response discrimination (0.5 to 8 Gy) in an independent human blood ex vivo dataset, and 100% accuracy for discriminating patients who received total body radiation. Three genes of this panel (CDKN1A, FDXR and BBC3) were also highly sensitive to LPS treatment in the absence of radiation exposure, and LPS co-treatment significantly affected their radiation responses. At the protein level, BAX and pCHK2-thr68 were elevated after radiation exposure, but the pCHK2-thr68 response was significantly decreased in the presence of LPS. Our combined panel yields an estimated 4-group accuracy of ∼90% to discriminate between radiation alone, inflammation alone, or combined exposures. Our findings suggest that DNA repair gene expression may be helpful to identify biodosimeters of exposure to radiation, especially within high-complexity exposure scenarios.
Properties of "diplophage": a lipid-containing bacteriophage (1977)

We describe the purification and properties of Dp-1, a bacteriophage isolated from Diplococcus pneumoniae. The phage was sensitive to the organic solvents deoxycholate and Sarkosyl, and its infectivity was reduced by treatment with phospholipase C. Electron microscopy indicated the presence of a double-layered coat around the phage particles. Purified phage preparations contained lipid amounting to about 8.5% of the dry weight of the phage, and thin-layer chromatography resolved the lipids into four components. The phage had a buoyant density in CsCl of 1.47 g/cm3, and a sedimentation constant in 0.1 M NaCl of 313S. Analysis in acrylamide gel electrophoresis indicated the presence of three major proteins. Dp-1 DNA shows a density of 1.681 g/cm3. Neutralizing antisera against the phage have a low potency (K less than 120/min).
ChemInform Abstract: Polymer‐Assisted‐Deposition: A Chemical Solution Route for a Wide Range of Materials (2013)

Abstract Review: 58 refs.
Characterization of serotonergic neurons using concurrent fluorescent retrograde axonal tracing and immunohistochemistry. (1982)

Free accessAbstractFirst published August 1982Characterization of serotonergic neurons using concurrent fluorescent retrograde axonal tracing and immunohistochemistry.D Van der Kooy and P E SawchenkoVolume 30, Issue 8https://doi.org/10.1177/30.8.6181121
Ultrasound Localization and Percutaneous Electrical Stimulation of the Hypoglossal Nerve and Ansa Cervicalis (2020)

The hypoglossal nerve and AC<sub>ST</sub> can be safely stimulated via percutaneous electrode placement. Larger trials of percutaneous stimulation may help to identify responders to different RNS therapies for OSA with temporary or permanent percutaneous electrodes. Techniques for electrode design, nerve localization, and electrode placement are described.
Preparation and Properties of High Hardness Ultraviolet Curable Polyethylene Terephthalates Surface Coatings Modified with Octavinyl-Polyhedral Oligomeric Silsesquioxane (2018)

Using organic coatings helps to protect PET (polyethylene terephthalates) surfaces, improve surface hardness, scratch resistance, and solvent resistance, prolong the service life of PET film, and to expand their scope of applications. There were some disadvantages, including poor flexibility and impact resistance in high-hardness coatings; organic coatings should also be modified to improve the toughness. Herein, a UV (ultraviolet curing) curable high-hardness organic coating used in PET surface protection was prepared and modified with inorganic nanoparticles, such as OVPOSS (octavinyl-polyhedral oligomeric silsesquioxane). The effects of the categories of nanoparticles on the coating performance were studied. UV-Vis spectra (ultraviolet visible light spectra), FT-IR (Fourier transform infrared spectrometer), TGA (thermogravimetric analysis), DMA (dynamic-mechanical), SEM (field emission scanning electron microscope), and AFM (atomic force microscope) were used to characterize the properties of the coatings. The results showed that the addition of eight-vinyl POSS to the organic coating significantly increased its glass transition temperature (Tg) from 100 to 120 °C, improved its storage modulus from 167.6 to 258.9 MPa, and raised its impact resistance and flexibility. The SEM and AFM images displayed that the eight-vinyl POSS particles were dispersed homogeneously in the coating, arranged in an ordered network, and had good compatibility with organic components. The film displayed excellent properties, including 4 H of the pencil hardness, 100 g cm of impact resistance, excellent flexibility, and 90% of light transmittance, with the addition of 0.3 wt % OVPOSS. TGA analysis revealed that the coating had good thermal stability, with 5% weight loss temperature up to 335 °C.
Regulation of IgE Synthesis by CD23/CD21 Interaction (1995)

At least two cell-derived signals have been shown to be necessary for the induction of immunoglobulin isotype switching in B cells. The first signal is given by either of the soluble lymphokines interleukin (IL)-4 or IL-13 which induce germline epsilon transcript expression, but alone is insufficient to trigger secretion of IgE. The second signal is provided by a physical interaction between B cells and activated T cells, basophils and mast cells, and it has been shown that the CD40/CD40L pairing is crucial for mediating IgE synthesis. In HIGM1 syndrome, which is characterized by greatly decreased levels of IgG, IgA and IgE, there are mutations in CD40L resulting in a completely non-functional extracellular domain. CD40L is therefore playing a central role in Ig switching. Amongst the numerous pairs of surface adhesion molecules, the CD23/CD21 pair seems to play a key role in the generation of IgE. The CD23 molecule is positively and negatively regulated by factors which increase or decrease IgE production, respectively. Antibodies to CD23 have been shown to inhibit IL-4-induced human IgE production in vitro and to inhibit antigen-specific IgE responses in a rat model, in an isotype-selective manner. CD23 interacts with CD21 on B cells, preferentially driving IgE production. CD23 recognises two main epitopes on the CD21 molecule. One region consists of short consensus repeat sequences (SCRs) 1-2 and the other of SCRs 5-8. In the latter region ASn370 and Asn295 are critical in the interaction with the lectin CD23. Therefore, a restricted number of cytokines and surface molecules seems to selectively regulate human IgE synthesis.
Codesign of PA, Supply, and Signal Processing for Linear Supply-Modulated RF Transmitters (2012)

This paper presents a method for achieving high-efficiency linear transmitters by codesign of the RF power amplifier (PA), dynamic supply, and signal processing. For varying amplitude signals, the average efficiency of the PA is improved by adding a supply modulator with requirements derived from nonstandard PA modeling. The efficient PA and supply modulator both introduce signal distortion. A targeted linearization procedure is demonstrated with reduced complexity compared to standard digital predistortion. Experimental results on a 2.14-GHz 81% efficient 40-W peak power GaN PA illustrate the codesign method by achieving 52.5% composite power-added efficiency with high linearity for a W-CDMA signal with a 23-MHz supply modulator bandwidth.
Scholarly productivity in communication studies: five-year review 2012–2016 (2017)

This study reports prolific scholarship trends in communication studies based on individual publication rates in 24 journals from the field for the years 2012–2016. In addition, we summarized data from a subset of journals considered to be most central to our discipline (Human Communication Research, Communication Research, Communication Monographs, and Journal of Communication). Results provide information about what characterizes the 32 individuals who could be considered prolific scholars across the total list of 24 journals, and the nine individuals who could be considered prolific in the central journals. It took nine and seven articles within the five-year period to make it onto each list, respectively. Our data indicate that many of the trends (e.g., mean publication rates, rates of collaboration, etc.) found in recent analyses have largely remained the same. Results are discussed as they pertain to individual characteristics and institutional environments that support research proliferation.
Wigner supersolid of excitons in electron-hole bilayers (2006)

Bilayer electron-hole systems, where carriers in one layer are electrons and carriers in the other are holes, have been actively investigated in recent years with the focus on Bose-Einstein condensation of excitons. This condensation is expected to occur when the layer separation d is much smaller than the interparticle distance r_sa_B within each layer. In this Brief Report, we argue for the existence of a state, Wigner supersolid, in which excitons are phase-coherent but form a Wigner crystal due to dipolar repulsion. We present the qualitative phase diagram of a bilayer system, and discuss properties and possible signatures of the Wigner supersolid phase.
Protective Effect of Brazilian Propolis Against Hepatic Oxidative Damage in Rats with Water‐immersion Restraint Stress (2012)

In the present study we examined the protective effect of Brazilian propolis against hepatic oxidative damage in rats with water-immersion restraint stress (WIRS) in comparison with that of vitamin E (VE). Fasted rats orally received Brazilian green propolis ethanol extract (BPEE; 10, 50 or 100 mg/kg), VE (250 mg/kg) or vehicle at 30 min before the onset of WIRS. Exposure of vehicle-treated rats to 6 h of WIRS caused liver cell damage, judging from the levels of serum alanine aminotransferase and aspartate aminotransferease, increased hepatic lipid peroxide, NO(x) contents and myeloperoxidase activity, and decreased hepatic non-protein SH, ascorbic acid contents and superoxide dismutase activity. Preadministration of BPEE (50 or 100 mg/kg) or VE to the stressed rats protected against the hepatic damage and attenuated the increased hepatic lipid peroxide and NO(x) contents and myeloperoxidase activity and the decreased hepatic non-protein SH and ascorbic acid contents and superoxide dismutase activity. These protective effects of BPEE (50 mg/kg) were greater than those of BPEE (100 mg/kg) and were almost equal to those of VE. These results indicate that BPEE protects against hepatic oxidative damage in rats exposed to WIRS possibly through its antioxidant and antiinflammatory properties such as VE.
A 28 GHz SiGe QVCO with an I/Q phase error detector for an 81&#x2013;86 GHz E-band transceiver (2014)

This paper presents a 28 GHz QVCO intended to be used in an 81-86 GHz E-band transceiver. E-band transceivers using e.g. 16 QAM modulation schemes are sensitive to I/Q phase error. Already a three degree error significantly degrades the bit error rate, and careful control of the phase error of the 28 GHz QVCO is therefore required. In the presented design the phase error can be tuned using four varactors, each connected to one of the QVCO outputs. The phase error is detected in two cross-coupled active mixers, creating a DC-level proportional to the phase error. The accuracy of the detector has been verified by Monte Carlo simulations showing a 3 sigma phase error of one degree. The QVCO is designed in a SiGe process with f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> = 200 GHz. The current consumption is 14 mA from a 1.5 V supply and 57 mA from a 2.5 V supply. The 2.5 V supply is dedicated to the detector and output buffers. At 1 MHz offset the phase noise equals -105 dBc/Hz with a FOM of -181 dBc/Hz and a FOM <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> of -186 dBc/Hz. The die area equals 1.3 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
Relative Influence of the Adeno-Associated Virus (AAV) Type 2 p5 Element for Recombinant AAV Vector Site-Specific Integration (2007)

The p5 promoter region of the adeno-associated virus type 2 (AAV-2) rep gene has been described as essential for Rep-mediated site-specific integration (RMSSI) of plasmid sequences in human chromosome 19. We report here that insertion of a full-length or minimal p5 element between the viral inverted terminal repeats does not significantly increase RMSSI of a recombinant AAV (rAAV) vector after infection of growth-arrested or proliferating human cells. This result suggests that the p5 element may not improve RMSSI of rAAV vectors in vivo.
Synthesis of charged triazatetrabenzcorroles, phthalocyanines and tetrapyridylporphyrin, and their activities in the co-sensitized photooxidation of 2-mercaptoethanol (2009)

Water soluble zwitterionic, as well as cationic and anionic triazatetrabenzcorroles (TBC), phthalocyanines (Pc) and a porphyrin (P) were synthesized and their sensitizer properties investigated. Monomerization of the sensitizers, including their mixtures, in the presence of a detergent was used as a basis for studying the fundamental effect of co-sensitization upon a known model reaction, viz. the photooxidation of 2-mercaptoethanol in aqueous alkaline solutions. Compared to single-component sensitizers, a remarkable improvement of the photocatalytic activity is observed in the case of co-sensitization employing molecules that absorb in different Q and Soret regions.
Characterization of the Lower Respiratory Tract Inflammation of Nonsmoking Individuals with Interstitial Lung Disease Associated with Chronic Inhalation of Inorganic Dusts (1987)

The pneumoconioses, interstitial lung disorders resulting from the inhalation of inorganic dusts, are associated with chronic inflammatory processes in the lower respiratory tract. To characterize these inflammatory processes in relation to the pathogenesis of these disorders, we studied 39 nonsmoking individuals with long-term occupational exposures to inorganic dust and functional evidence of interstitial disease (asbestosis, n = 18; coal workers' pneumoconiosis, n = 15; silicosis, n = 6). In all 3 disorders, the inflammation was dominated by alveolar macrophages. Because a common feature of these interstitial lung diseases is concurrent injury and fibrosis of alveolar walls, we assessed whether these alveolar macrophages were spontaneously releasing mediators capable of giving rise to these changes. Alveolar macrophages from the study population were spontaneously releasing increased amounts of superoxide anion and hydrogen peroxide (both p less than 0.01 compared to normals), oxidants capable of injuring lung parenchymal cells. The alveolar macrophages were also spontaneously releasing significantly increased amounts of fibronectin and alveolar macrophage-derived growth factor (both p less than 0.01 compared to normals), mediators that act synergistically to signal fibroblast replication. Taken together, these findings define a major role for the alveolar macrophage in mediating the alveolar wall injury and fibrosis that characterize the common pneumoconioses and suggest that the alveolar macrophage is an important "target" for developing strategies designed to prevent loss of lung function in these individuals.
Acylation Enhances, but Is Not Required for, the Cytotoxic Activity of Mannheimia haemolytica Leukotoxin in Bighorn Sheep (2015)

Mannheimia haemolytica causes pneumonia in domestic and wild ruminants. Leukotoxin (Lkt) is the most important virulence factor of the bacterium. It is encoded within the four-gene lktCABD operon: lktA encodes the structural protoxin, and lktC encodes a trans-acylase that adds fatty acid chains to internal lysine residues in the protoxin, which is then secreted from the cell by a type 1 secretion system apparatus encoded by lktB and lktD. It has been reported that LktC-mediated acylation is necessary for the biological effects of the toxin. However, an LktC mutant that we developed previously was only partially attenuated in its virulence for cattle. The objective of this study was to elucidate the role of LktC-mediated acylation in Lkt-induced cytotoxicity. We performed this study in bighorn sheep (Ovis canadensis) (BHS), since they are highly susceptible to M. haemolytica infection. The LktC mutant caused fatal pneumonia in 40% of inoculated BHS. On necropsy, a large number of necrotic polymorphonuclear leukocytes (PMNs) were observed in the lungs. Lkt from the mutant was cytotoxic to BHS PMNs in an in vitro cytotoxicity assay. Flow cytometric analysis of mutant Lkt-treated PMNs revealed the induction of necrosis. Scanning electron microscopic analysis revealed the presence of pores and blebs on mutant-Lkt-treated PMNs. Mass spectrometric analysis confirmed that the mutant secreted an unacylated Lkt. Taken together, these results suggest that acylation is not necessary for the cytotoxic activity of M. haemolytica Lkt but that it enhances the potency of the toxin.
FollowMe: Efficient Online Min-Cost Flow Tracking with Bounded Memory and Computation (2014)

One of the most popular approaches to multi-target tracking is tracking-by-detection. Current min-cost flow algorithms which solve the data association problem optimally have three main drawbacks: they are computationally expensive, they assume that the whole video is given as a batch, and they scale badly in memory and computation with the length of the video sequence. In this paper, we address each of these issues, resulting in a computationally and memory-bounded solution. First, we introduce a dynamic version of the successive shortest-path algorithm which solves the data association problem optimally while reusing computation, resulting in significantly faster inference than standard solvers. Second, we address the optimal solution to the data association problem when dealing with an incoming stream of data (i.e., online setting). Finally, we present our main contribution which is an approximate online solution with bounded memory and computation which is capable of handling videos of arbitrarily length while performing tracking in real time. We demonstrate the effectiveness of our algorithms on the KITTI and PETS2009 benchmarks and show state-of-the-art performance, while being significantly faster than existing solvers.
Physik und Physiker im Dritten Reich (1993)

Das Rahmenthema ≪Wissenschaft und politische Macht≫ wird hier am Beispiel der Physik und der Physiker im Dritten Reich behandelt. Im ersten Teil geht es um das Verhältnis von Wissenschaft und politischer Macht, wie es sich bis 1933 in Deutschland ausgebildet hat. Im zweiten Teil werden die ganz anderen Massstäbe des Dritten Reiches behandelt. Im dritten Teil, dem Hauptstück, sollen die Ereignisse von 1933 bis 1939 beleuchtet werden und im vierten und letzten Teil schliesslich die Kriegsjahre.
Prospective motion correction with NMR markers using only native sequence elements (2017)

The proposed approach permits high-precision motion tracking and PMC with standard imaging sequences. It does so without altering sequence design and thus overcomes a key hindrance to routine motion tracking with NMR markers. Magn Reson Med 79:2046-2057, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Peroxide-metal ion oxidations. II. Convenient synthesis of imides (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPeroxide-metal ion oxidations. II. Convenient synthesis of imidesArthur R. Doumaux Jr. and D. J. TreckerCite this: J. Org. Chem. 1970, 35, 7, 2121–2125Publication Date (Print):July 1, 1970Publication History Published online1 May 2002Published inissue 1 July 1970https://pubs.acs.org/doi/10.1021/jo00832a004https://doi.org/10.1021/jo00832a004research-articleACS PublicationsRequest reuse permissionsArticle Views389Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Novel method of patterning YBaCuO superconducting thin films (1989)

A unique method of patterning YBaCuO thin films based on the inhibition of superconductivity by Si-YBaCuO intermixing has been developed. In the experiment, a thin Si film was first evaporated on a MgO substrate and subsequently patterned using laser direct-write etching. Multilayered YBaCuO thin films were then deposited by e-beam evaporation and annealed in a rapid thermal annealing system for 30–90 s at 980 °C. The YBaCuO film deposited on the silicon regions became insulating. Auger depth profiling measurements indicate that Si-YBaCuO intermixing had occurred in these areas. Between the insulating regions, narrow YBaCuO superconducting lines were formed. For both 10-μm-wide, 1-mm-long and 2.5-μm-wide, 80-μm-long lines, the Tc was observed above 76 K. The critical current density of the lines was measured to be 300 A/cm2 at 75 K. This patterning technique may be useful for fabrication of high Tc superconducting interconnects and devices.
The Management of Unilateral Poorly Functioning Kidneys in Patients With Posterior Urethral Valves (1997)

Based on our results we believed that unilateral poorly functioning kidneys in patients with posterior urethral valves can be safely preserved in select patients without hypertension and pyelonephritis. Reimplantation to correct reflux may be preferable to nephroureterectomy in specific situations, such as when contralateral function is suboptimal and the contralateral ureter needs reimplantation. When indicated, reimplantation can be performed successfully if abnormal urodynamic parameters are addressed preoperatively. In fact, treating abnormal urodynamic findings may lead to spontaneous reflux resolution.