gebhart/patrepeval huggingface dataset:
Preparation and Reactions of Derivatives of Squaric Acid. Alkoxy-, Hydroxy-, and Aminocyclobutenediones1 (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and Reactions of Derivatives of Squaric Acid. Alkoxy-, Hydroxy-, and Aminocyclobutenediones1Sidney Cohen and Saul G. CohenCite this: J. Am. Chem. Soc. 1966, 88, 7, 1533–1536Publication Date (Print):April 1, 1966Publication History Published online1 May 2002Published inissue 1 April 1966https://pubs.acs.org/doi/10.1021/ja00959a040https://doi.org/10.1021/ja00959a040research-articleACS PublicationsRequest reuse permissionsArticle Views1797Altmetric-Citations118LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Supplementary Figure 3 from c-Abl Modulates Tumor Cell Sensitivity to Antibody-Dependent Cellular Cytotoxicity (2023)

&lt;p&gt;Characterization of a real-time cell assay (RTCA) for assessment of ADCC.&lt;/p&gt;
Optical biotelemetry in moving vehicles (2002)

For the improvement of the life-saving operation in an emergency medicine, a technique of the telemedicine using mobile communication was proposed. To obtain different kinds of physiological data from a patient in an ambulance, an optical biotelemetry technique was applied. Using an indirect light transmission, the wireless measurement became possible even in the moving car with the paramedic personnel working actively. A test system was developed and its fundamental characteristics were measured. Through the experiments in a moving car, the feasibility of the proposed technique was verified.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Determination of the rate and equilibrium constants for oxygen and carbon monoxide binding to R-state human hemoglobin cross-linked between the alpha subunits at lysine 99. (1991)

The kinetics of O2 and CO binding to R-state human hemoglobin A0 and human hemoglobin cross-linked between the alpha chains at Lys99 residues were examined using ligand displacement and partial photolysis techniques. Oxygen equilibrium curves were measured by Imai's continuous recording method (Imai, K. (1981) Methods Enzymol. 76, 438-449). The rate of the R to T transition was determined after full laser photolysis of the carbon monoxide derivative by measuring the resultant absorbance changes at an isosbestic point for ligand binding. Chemical cross-linking caused the R-state O2 affinity of alpha subunits to decrease 6-fold compared with unmodified hemoglobin. This inhibition of O2 binding was the result of both a decrease in the rate constant for ligand association and an increase in the rate constant for dissociation. The O2 affinity of R-state beta subunits was reduced 2-fold because of an increase in the O2 dissociation rate constant. These changes were attributed to proximal effects on the R-state hemes as the result of the covalent cross-link between alpha chain G helices. This proximal strain in cross-linked hemoglobin was also expressed as a 5-fold higher rate for the unliganded R to T allosteric transition. The fourth O2 equilibrium binding constant, K4, measured by kinetic techniques, could be used to analyze equilibrium curves for either native or cross-linked hemoglobin. The resultant fitted values of the Adair constants, a1, a2, and a3 were similar to those obtained when K4 was allowed to vary, and the fits were of equal quality. When K4 was fixed to the kinetically determined value, the remaining Adair constants, particularly a3, became better defined.
ON THE REINFORCING EFFECT OF MULTIWALL CARBON NANOTUBES IN A NATURAL RUBBER-BASED CARBON BLACK FILLED RUBBER COMPOUND (2008)

Multiwall carbon natotubes (MWCNTs) were studied as reinforcing filler in a natural rubber based formulation as partial replacement of carbon black [1]. The reinforcing effect exerted by the addition of MWCNTs was dramatic.Using the Enstein‐Gold‐Guth equation the reinforcement has been evaluated quantitatively and it has been shown that it derives from the anisotropy factor f (or shape factor) of MWCNTs used in the present work. In fact f reaches the value of 52.5, one order of magnitude higher than a reinforcing carbon black where the shape factor f is ∼6.
Traditional Practice vs. New Tools and Routines in Stroke Treatment (2012)

In Norway, it is a national goal to provide more patients with thrombolytic treatment. A referring hospital and a specialist hospital have implemented videoconferencing (VC) equipment to share knowledge and discuss stroke patients, regarding thrombolytic treatment. VC has only been used four times within the 19 months that the service has been available. The objective in this article is to increase the understanding of the contradiction between the need for knowledge-sharing through VC technology, as well as the reasons for low frequency of use when discussing stroke patients. Semi-structured interviews were conducted with 13 professionals. The results illustrate how the technology per se is not the reason for the low frequency use. Health care is shaped by behavior, traditional rules, standards and division of labor. By using cultural historical activity theory (CHAT) as a framework, we illustrate the importance of understanding the historic way of performing an activity to be able to expand the treatment activity in the future.
Short Protocols in Pharmacology and Drug Discovery: A Compendium of Methods from Current Protocols in Pharmacology (2007)

Short Protocols in Pharmacology and Drug Discovery provides condensed descriptions of more than 350 methods compiled from the successful title Current Protocols in Pharmacology. The book is specifically designed to provide quick access to step-by-step instructions for the essential methods used in every major area of pharmaceutical research, and especially stresses drug discovery techniques. This volume is an authoritative and indispensable guide for all life scientists, researchers, and students at the graduate and advanced undergraduate level, doing research in academic, government, and pharma/biotech laboratories.
Abstract 3347: A proneural signature profile predicts response to Notch inhibition in glioma stem cells (2012)

Abstract The Cancer Genome Atlas Network described genomic abnormalities and gene expression-based molecular subtypes of GBM that showed a strong relationship between subtypes, genomic alterations and different neural lineages. Future studies are required to elucidate the intricate relationship between tumor subtypes and treatment response. We have thus embarked on a comprehensive effort to detecting expression signatures that are associated with response to the therapy and these signatures may allow prospective selection of patients with high likelihood of responding to therapy. Notch signaling pathway is an evolutionarily conserved pathway that plays an important role in multiple cellular and developmental processes including cell fate decision, differentiation, proliferation, survival, angiogenesis and migration. Recent studies indicate that the Notch signaling pathway regulates normal stem cells in the brain, and glioma stem Cells (GSCs) with high Notch activity. We investigated the effects of Notch pathway inhibition on GSCs growth using commercially available inhibitors. Drug cytotoxicity test on 16 GSCs show differential growth response to Notch inhibitors stratifying GSCs into two groups: responders (6 cell lines) vs non-responders (10 cell lines). Gene expression clustering identified a responder gene signature enriched in 1: proneural genes such as Olig2, Sox-9, NKX2-2, and 2: Notch signaling component such as Notch-1, Notch-3, Hes-3 and Hes-5. These signature were validated by western blot analysis. Treatment with Notch inhibitors reduced neurosphere formation in vitro accompanied with attenuated Notch intracellular domain (NICD), Hes-1, Hes-3, and Hes-5. In addition, the expression of nestin-the stem cell marker was reduced and an increased expression of lineage differentiation markers TuJ1 and GFAP was observed following Notch inhibition. In conclusion, we have identified a responder signature for a group of glioma stem cells that can be targeted by Notch inhibitors and this may allow the selection of patients with high likelihood of responding to this therapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3347. doi:1538-7445.AM2012-3347
A Deep-Learning Aided Diagnostic System in Assessing Developmental Dysplasia of the Hip on Pediatric Pelvic Radiographs (2022)

The AI-aided diagnosis system can quickly and automatically measure important parameters and improve the quality of clinical diagnosis and screening referral process with a convenient and efficient way.
Application of reinforcement learning to admission control in CDMA network (2002)

The paper describes an admission control algorithm for the CDMA networks which is able to adapt to the operating environment. The algorithm is based on the principle of reinforcement learning and it achieves near-optimal performance for various radio propagation conditions and network operator's objectives. The performance evaluation results for different state space alternatives and algorithm parameters are presented and compared with the conventional admission control based on the power thresholds.
A ferromagnetic tetranuclear CuII complex: catecholase and phenoxazinone synthase activities (2017)

A crystallographically characterized tetranuclear Cu(II) complex [CuII4(L)4] (1) [H2L = N-(2-hydroxyethyl)-3methoxysalicylaldimine] is found to show overall ferromagnetic exchange coupling. High nuclearity transition-metal complexes are of current interest for their possible utility in molecular magnetism1 with special emphasis on single molecule magnets.2 Copper has long been the metal of choice for assembling high nuclearity cluster3 primarily based on ligands with oxygen along with nitrogen donor atoms. Moreover, dinuclear copper complexes play an important role in biological metalloenzymes. Complex (1) mimics the catalytic activity of the plant enzyme catechol oxidase by oxidising 3,5-di-tertbutylcatechol to its corresponding quinone in methanol and dichloromethane medium in presence of aerial oxygen. The reaction follows Michaelis-Menten enzymatic reaction kinetics with turnover numbers (Kcat) 6.99 103 and 1.85 103 h-1 in methanol and dichloromethane, respectively. 1 is also phenoxazinone synthase active in methanol medium with a turnover number of 1.21 105 h-1.
Acetylcholine receptor in rabbit thymus: antigenic similarity between acetylcholine receptors of muscle and thymus. (1980)

This study was performed to examine the presence and immunological properties of acetylcholine receptor (AChR) in rabbit thymus. Binding of 125I-alpha Bungarotoxin (alpha BGT) to Triton extract from rabbit thymus was saturable (half saturation value: 10 X 10(-9) M) and occurred with at least two affinities, a high one with a dissociation constant of 1.1 X 10(-10)M and a low affinity one with a dissociation constant of 2 X 10(-9)M. The complex formation of 125I-alpha BGT-thymus extract was inhibited by both carbamylcholine and D-tubocurarine. These results indicate the existence of AChR in rabbit thymus. Antibody to AChR which was purified from experimental myasthenic rabbits with Narke AChR-affinity gel and labelled with 125I was used to identify the receptor antigenicity in rabbit thymus. Specific binding of 125I-antibody to thymic extract was demonstrated by the DEAE-paper disc assay. It is concluded from these results that AChRs with a similar antigenicity to that of skeletal muscle AChR exist in rabbit thymus. Our findings obtained in this study will support a hypothesis that the primary immunogen in myasthenia gravis may be AChR in thymus and an autoimmune reaction against AChR might be initiated within the thymus gland itself.
Three results on the PageRank vector: eigenstructure, sensitivity, and the derivative (2007)

The three results on the PageRank vector are preliminary but shed light on the eigenstructure of a PageRank modified Markov chain and what happens when changing the teleportation parameter in the PageRank model. Computations with the derivative of the PageRank vector with respect to the teleportation parameter show predictive ability and identify an interesting set of pages from Wikipedia.
The use of modified mosquitoes in Brazil for the control of Aedes aegypti: methodological and ethical constraints (2014)

The use of modified mosquitoes
Epigenetic Mechanisms through which Toll-like Receptor–9 Drives Idiopathic Pulmonary Fibrosis Progression (2012)

Patients with idiopathic pulmonary fibrosis (IPF) survive a median of 3 years after diagnosis, but a high degree of variability in longitudinal disease progression has been observed. Unfortunately, physiology and clinical parameters determined at the time of diagnosis have proven inaccurate in predicting the rate at which IPF ultimately progresses. A mechanistic explanation for disease progression in patients with IPF is presently unclear, but we have recently shown that hypomethylated CpG DNA drives the rapid progression of fibrotic lung disease through the differentiation of pulmonary fibroblasts into myofibroblasts through a TLR9-dependent mechanism. Furthermore, we recently reported that the clinical progression of IPF might be a consequence of aberrant microRNA processing. Using this framework of data, we are presently addressing the following specific hypothesis: hypomethylated CpG DNA activation in pulmonary fibroblasts leads to aberrant micro RNA processing, thereby promoting the rapid progression of IPF.
Time Resolved in situ DXAFS Revealing Highly Active Species of PdO Nanoparticle Catalyst for CH4 Oxidation (2018)

Abstract The highly active species of Pd/Al 2 O 3 catalysts for methane combustion was revealed by in situ time‐resolved dispersive X‐ray absorption fine structure (DXAFS) spectroscopy. By using CH 4 as a reduction agent, PdO in Pd/Al 2 O 3 is reduced in a 2‐step model involving Pd 0 nucleation and growth of Pd 0 domain in a PdO particle. Kinetic analysis of the 2‐step model reduction of PdO nanoparticles leads to a suggestion that partial formation of Pd 0 in a PdO particle accelerates methane combustion.
Measuring chlorinated hydrocarbons in combustion by use of Fourier-transform infrared spectroscopy (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMeasuring chlorinated hydrocarbons in combustion by use of Fourier-transform infrared spectroscopyMatthew J. Hall, Donald Lucas, and Catherine P. KoshlandCite this: Environ. Sci. Technol. 1991, 25, 2, 260–267Publication Date (Print):February 1, 1991Publication History Published online1 May 2002Published inissue 1 February 1991https://pubs.acs.org/doi/10.1021/es00014a007https://doi.org/10.1021/es00014a007research-articleACS PublicationsRequest reuse permissionsArticle Views116Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Three-dimensional complex-shaped photopolymerized microparticles at liquid crystal interfaces (2012)

Microparticles of arbitrary shapes immersed in the bulk of nematic fluids are known to produce dipolar or quadrupolar elastic distortions that can mediate long-range colloidal interactions. We use two-photon photopolymerization to obtain complex-shaped surface-bound microparticles that are then embedded into a nematic liquid crystal host with a uniform far-field director. By means of three-dimensional imaging with multi-photon excitation fluorescence polarizing microscopy, we demonstrate low-symmetry, long-range elastic distortions induced by the particles in the liquid crystal director field. These director distortions may provide a means for controlling elastic interactions in liquid crystals between custom-designed photopolymerized microparticles attached to confining solid substrates and nematic fluid-borne colloids, thus enabling elasticity-mediated templated self-assembly.
Blind receivers for PSK signals transmitted over Rayleigh frequency-flat fading channels (2002)

This paper describes detection algorithms for coded and uncoded M-PSK signals transmitted over frequency-flat fading channels. Fading distortion is estimated with per-survivor methods using the outputs of two receive filters. The proposed algorithms do not require information on the fading statistics and are dubbed blind algorithms. The error-rate performance is assessed by simulation for uncoded and trellis-coded PSK and is compared with the performance of previously proposed detection schemes.
ChemInform Abstract: A Novel Dipeptidomimetic Containing a Cyclic Threonine. (2010)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Effect of microstructure factors and cold work on the hydride precipitation in zircaloy-4 sheet. (1991)

The effects of microstructure factors and manufacturing process on the precipitation of hydrides in Zircaloy-4 plate have been studied. A quantitative technique described in Ref. 1 has been used to evaluate the susceptibility to radial hydride formation under the influence of texture, residual stress and externally applied tensile stress. Image treatment was carried out to determine the average orientation of hydrides. The hydride oriented threshold stresses were estimated, following an improved approach which had been firstly developed by Sauthoff and then applied to Zr-H system by Puls.2 Both analytical and experimental results indicate that the threshold stress is influenced by the microstructure and thermomechanical treatment of Zircaloy-4, and by the hydrogen concentration in a very complex manner. After examining the hydride morphologies of formerly cold-rolled sheets of two different fabrication routes in stress-relieved, recrystallized and treated states, it may be concluded that the distribution morphology of hydrides can be selected, and their noxiousness and effective contribution to the embrittlement can be thus minimized by controlling texture, grain structure, and manufacturing process.
Defining the role of the forensic community mental health nurse (1996)

The aim of this article is to identify how the forensic community mental health nurse is able to care for families of people who have a diagnosis of schizophrenia and are being cared for within a forensic environment
Changes in Fitness following a Behavioral Weight Loss Program in Severely Obese Individuals (2011)

Behavioral weight loss programs that include both dietary and exercise components typically result in fitness improvements. However, severely obese individuals (BMI≥40 kg/m2) are often excluded from these programs; therefore it is unclear whether this population achieves similar increases in fitness and who among them are most likely to experience the greatest improvements. PURPOSE: To examine the effect of an intensive lifestyle intervention (ILI) on fitness and to identify factors associated with changes in fitness following a 1- year weight loss intervention. METHODS: 2570 participants in the Look AHEAD trial for individuals with type 2 diabetes were randomized to ILI and 2575 were randomized to the diabetes support and education (DSE) arm. ILI participants were instructed to reduce their caloric intake and increase their exercise to ≥175 min/week while DSE participants received general weight loss guidelines. All subjects completed a maximal exercise test at baseline and a submaximal test to 80% of age-predicted maximal heart rate (HRmax) at 1-year. Change in fitness was calculated as the difference in the MET value at 80% HRmax between baseline and 1-year. RESULTS: Severely obese ILI participants (N=492; BMI: mean±sd=44.8 ± 3.9 kg/m2,age: 56.4 ± 6.4 years; 66.2% female) had significant (p<0.001) improvements in absolute fitness (0.98 ± 1.2 METs) and % change in fitness (24.4 ± 30.1%) at 1-year which were significantly greater than individuals in DSE with severe obesity (p<0.001). Among ILI participants, absolute fitness was similar (p=0.68) and % change in fitness (p<0.05) was greater among the severely obese compared to those with a BMI <40. In ILI participants who were severely obese, those who had a lower baseline BMI, were younger, less fit, and were male, experienced the greatest improvements in fitness at 1 year (ps<0.001). CONCLUSIONS: Severely obese individuals achieved significant improvements in fitness at 1-year in an intensive lifestyle intervention that were similar to those with lesser degrees of obesity. Severely obese participants who were less fit at baseline experienced the largest improvements in absolute fitness at 1- year, suggesting that these individuals may receive the greatest fitness benefit from a behavioral weight loss program.
On reducing the target fault list of crosstalk-induced delay faults in synchronous sequential circuits (2002)

This paper describes a method of identifying a set of crosstalk-induced delay faults which may need to be tested in synchronous sequential circuits. In this process, the false crosstalk-induced delay faults that need not (and/or can not) be tested in synchronous sequential circuits are also identify. Our method classifies the pairs of aggressor and victim lines, using topological information and timing information, to deduce a set of faults that need to be tested in a sequential circuit. Experimental results for ISCAS'89 benchmark circuits show that the lists of the target faults obtained by the proposed method are sufficiently smaller than the sets of all possible combinations of faults.