gebhart/patrepeval huggingface dataset:
Faculty Opinions recommendation of Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells. (2009)

Neuropilin 1 (Nrp1) is a coreceptor for vascular endothelial growth factor A165 (VEGF-A165, VEGF-A164 in mice) and semaphorin 3A (SEMA3A). Nevertheless, Nrp1 null embryos display vascular defects that differ from those of mice lacking either VEGF-A164 or Sema3A proteins. Furthermore, it has been recently reported that Nrp1 is required for endothelial cell (EC) response to both VEGF-A165 and VEGF-A121 isoforms, the latter being incapable of binding Nrp1 on the EC surface. Taken together, these data suggest that the vascular phenotype caused by the loss of Nrp1 could be due to a VEGF-A164/SEMA3A-independent function of Nrp1 in ECs, such as adhesion to the extracellular matrix. By using RNA interference and rescue with wild-type and mutant constructs, we show here that Nrp1 through its cytoplasmic SEA motif and independently of VEGF-A165 and SEMA3A specifically promotes a5b1-integrin-mediated EC adhesion to fibronectin that is crucial for vascular development. We provide evidence that Nrp1, while not directly mediating cell spreading on fibronectin, interacts with a5b1 at adhesion sites. Binding of the homomultimeric endocytic adaptor GAIP interacting protein C terminus, member 1 (GIPC1), to the SEA motif of Nrp1 selectively stimulates the internalization of active a5b1 in Rab5-positive early endosomes. Accordingly, GIPC1, which also interacts with a5b1, and the associated motor myosin VI (Myo6) support active a5b1 endocytosis and EC adhesion to fibronectin.
Interim monitoring of nonrandomized prospective studies that invoke propensity scoring for decision making (2019)

DeSantis, Stacia M. PhD; Swartz, Michael D. PhD; Greene, Thomas J. PhD; Fox, Erin E. PhD; Holcomb, John B. MD; Wade, Charles E. PhD; the PROHS Study Group Author Information
Speckle (1986)

This issue and the next (June 1986) of Optical Engineering contain about half of the papers that were presented at the International Conference on Speckle, held in San Diego, August 20-23, 1985.* The aim of the conference was to provide a forum for the discussion of all aspects of speckle and its applications. Experts from 11 countries gathered to exchange knowledge and to interact with each other. There were papers on speckle with laser light, speckle from astronomical objects, and speckle with ultrasounds, microwaves, and the infrared. Research and review papers were presented on the statistical properties of speckle, speckle me trology, speckle in imaging and radar systems, speckle in astronomy, and speckle interferometry. Many new results were presented for the first time. The conference showed that speckle is a lively and rapidly evolving field, not only in the study of speckle phenomena but also for its practical applications. Speckle metrology and speckle astronomy in particular have matured to the point where commercial equipment is being built especially for those applications, yielding results that can be obtained by no other methods. Because of deadline considerations and requirements of the refereeing and revision processes, it was not possible to group all the papers on one subject together in one issue, although all the speckle astronomy papers will appear in the June issue. The papers included in these two special lissuues of Optical Engineering represent a snapshot of the lively field of speckle as it exists today.
Promoted Stereocomplex Crystallization in Supramolecular Stereoblock Copolymers of Enantiomeric Poly(Lactic Acid)s (2016)

Telechelic and 3-arm star-shaped poly(l-lactic acid)s (PLLAs) and poly(d-lactic acid)s (PDLAs) end-functionalized by 2-ureido-4[1H]-pyrimidione (UPy) self-complementary quadruple hydrogen-bonding motifs were synthesized by terminally modifying the corresponding hydroxyl-terminated polymers. The PLLA/PDLA stereoblock supramolecular polymers (sb-SMPs) with linear and branched architectures were further prepared by mixing the UPy end-functionalized telechelic, 3-arm star-shaped PLLA and PDLA through the dimerization of UPy groups, as verified by viscometry. Crystallization kinetics, polymorphic crystalline structure, and lamellae morphology of the PLLA/PDLA sb-SMPs were investigated and compared with the corresponding blends without UPy end functionalities. Compared to the PLLA/PDLA blends, the sb-SMPs exhibit higher crystallization rate and prefer to crystallizing into the high-melting-point stereocomplex (sc), rather than the low-melting-point homocrystallite in both the nonisothermal and isothermal crystallization processes. The sc crystallization ability and crystallization rate of sb-SMPs are further enhanced with increasing the concentration of terminal UPy groups or decreasing the block lengths of PLLA and PDLA. The enhanced sc crystallization ability and faster crystallization rate of sb-SMPs are ascribed to the hydrogen bonding interactions formed between the terminal UPy groups of PLLA and PDLA. Due to the preferential sc crystallization, the sb-SMPs exhibit smaller long periods than the corresponding PLLA/PDLA blends.
Optimal Joint Power and Subcarrier Allocation for Full-Duplex Multicarrier Non-Orthogonal Multiple Access Systems (2017)

In this paper, we investigate resource allocation algorithm design for multicarrier non-orthogonal multiple access (MC-NOMA) systems employing a full-duplex (FD) base station for serving multiple half-duplex (HD) downlink and uplink users simultaneously. The proposed algorithm is obtained from the solution of a non-convex optimization problem for the maximization of the weighted sum system throughput. We apply monotonic optimization to develop an optimal joint power and subcarrier allocation policy. The optimal resource allocation policy serves as a system performance benchmark due to its high computational complexity. Furthermore, a suboptimal iterative scheme based on successive convex approximation is proposed to strike a balance between computational complexity and optimality. Our simulation results reveal that the proposed suboptimal algorithm achieves a close-to-optimal performance. In addition, FD MC-NOMA systems employing the proposed resource allocation algorithms provide a substantial system throughput improvement compared with conventional HD multicarrier orthogonal multiple access (MC-OMA) systems and other baseline schemes. In addition, our results unveil that FD MC-NOMA systems enable a fairer resource allocation compared with traditional HD MC-OMA systems.
Inhibitory Effect of Dihydroaustrasulfone Alcohol on the Migration of Human Non-Small Cell Lung Carcinoma A549 Cells and the Antitumor Effect on a Lewis Lung Carcinoma-Bearing Tumor Model in C57BL/6J Mice (2014)

There are many major causes of cancer death, including metastasis of cancer. Dihydroaustrasulfone alcohol, which is isolated from marine coral, has shown antioxidant activity, but has not been reported to have an anti-cancer effect. We first discovered that dihydroaustrasulfone alcohol provided a concentration-dependent inhibitory effect on the migration and motility of human non-small cell lung carcinoma (NSCLC) A549 cells by trans-well and wound healing assays. The results of a zymography assay and Western blot showed that dihydroaustrasulfone alcohol suppressed the activities and protein expression of matrix metalloproteinase (MMP)-2 and MMP-9. Further investigation revealed that dihydroaustrasulfone alcohol suppressed the phosphorylation of ERK1/2, p38, and JNK1/2. Dihydroaustrasulfone alcohol also suppressed the expression of PI3K and the phosphorylation of Akt. Furthermore, dihydroaustrasulfone alcohol markedly inhibited tumor growth in Lewis lung cancer (LLC)-bearing mice. We concluded that dihydroaustrasulfone alcohol is a new pure compound with anti-migration and anti-tumor growth activity in lung cancer and might be applied to clinical treatment in the future.
ChemInform Abstract: Molecular Modelling of Three‐Dimensional Structure of 1,25‐ Dihydroxycholecalciferol and Its A‐Ring Analogues. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Rapid electromagnetic warming of cells and tissues (1999)

We describe a system for thawing frozen cell suspensions and tissues by electromagnetic absorption. A 25-ml sample is heated in a cylindrical resonant cavity, which is excited in three modes all close to 434 MHz. Maximum warming rates are over 10 degrees C/s (600 C/min), and a frozen sample may be brought from -65 degrees C to room temperature in < 30 s, with final spatial differences of < 20 degrees C. Samples may be frozen externally, or cooled within the cavity at typically 1 degree C/min. We have also used the resonant cavity to measure the permittivity and conductivity of the sample at temperatures from -83 degrees C to +8 degrees C. By measuring the heat capacity of the sample, we have calculated the power deposited in it as a function of its temperature. The system is currently being used to investigate the effect of warming rate on cell survival.
The Effects of Text Type, Text Length and Text Difficulty on Vocabulary Retention Through Glossing (2016)

Vocabulary plays a pivotal role in the EFL classrooms, but the outcome for recalling the vocabulary items are not satisfactory. As a result, the current study aims at examining the effects of glossing on different types of texts with different difficulty levels and varying lengths on vocabulary retention. In a quasi-experimental within subject design two types of text, namely, expository and narrative, three difficulty levels of easy, standard and difficult and two text lengths, including short and long were utilized. Forty-one participants were exposed to the 12 texts and then took the post-test. Repeated measures ANOVA indicated that there were significant differences in vocabulary retention of students (F 7.72), p=. 05. The findings of post-hoc analysis Tukey test indicated that the texts which were short with regard to length, easy with regard to difficulty, and expository with respect to type helped students retain the glossed words better than other texts.
Coherent Pixel Design of Metasurfaces for Multidimensional Optical Control of Multiple Printing‐Image Switching and Encoding (2018)

Abstract Printing image based on metasurface has attracted enormous research interests due to its subwavelength resolution, full‐color printing, and durable properties. Based on the spatially multiplexed pixels, the printing image using metasurface can be switched optically by altering the optical parameters, such as polarization and incident wavelength. However, such multiplexed pixel design has several problems, including the cross‐talk among different wavelengths, limitation to linear polarizations, and incapability for incident‐angle control. Here, a general method for pixel design, called the coherent pixel, which can overcome the problems and be used for multiple printing‐image switching controlled by arbitrary optical parameters (arbitrary incident angle, polarization, and wavelength) is proposed. Based on this coherent pixel, metasurface devices with novel functionalities can be realized, such as incident‐angle controlled and arbitrary polarization‐controlled printing images, which are not feasible with previous conventional pixel design method. The suitability and superiority of the coherent pixel for encryption application is also discussed. Such printing‐image switching controlled with arbitrary optical parameters should pave the way for various applications, including various functional switchable optical devices, image displays, and information encryption.
Functional and Physiological Effects of Treadmill Training Induced by Buspirone, Carbidopa, and L-DOPA in Clenbuterol-Treated Paraplegic Mice (2011)

These findings suggest that locomotor movement and muscle properties can be restored to near-normal levels after several weeks of BCD treatment, regular training, and clenbuterol in completely paraplegic animals.
Effect of Bend Geometry on Heat Transfer and Pressure Drop in a Two-Pass Coolant Square Channel for a Turbine (2012)

This paper presents a comparative numerical study of turbulent flow inside a two-pass internal cooling channel with different bend geometries. The goal is to find a geometry that reduces the bend related pressure loss and enhances overall heat transfer coefficient. A square channel with a round U-bend is taken as a baseline case and the heat transfer and pressure drop for nine different bend geometries are compared with the baseline. Modifications for the bend geometry are made along the channel divider wall and at the end wall of the 180 deg bend. The bend geometries studied include: (1) a turning vane geometry, (2) an asymmetrical bulb, (3) three different symmetrical bulbs, (4) two different bow shaped geometries at the end wall, (5) a bend with an array of dimples in the bend region, and (6) finally a combination of bow geometry and dimples. The solution procedure is based on a commercial finite volume solver using the Reynolds averaged Navier–Stokes (RANS) equation and a turbulence model. A two equation realizable k-ɛ model with enhanced wall treatment is used to model the turbulent flow. It was found that the bend geometry can have a significant effect on the overall performance of a two-pass channel. The modified bend geometries are compared with the baseline using Nusselt number ratios, friction factor ratios, and thermal performance factors (TPF) as the metrics. All the modified bend geometries show increase in the TPF with the symmetrical bulb configuration showing nearly a 40% reduction in friction factor ratio and a 30% increase in thermal performance. The highest TPF (41% increase over baseline) is observed for the symmetrical bulb combined with a bow along the outer walls and surface dimples.
Therapeutic Approach to Hyperkalemia (2002)

The foremost step in the initial clinical management of hyperkalemia is to decide whether a hyperkalemic patient requires immediate treatment to avoid a life-threatening situation (serum potassium concentration >6.0 mEq/l and EKG changes). When the decision for urgent treatment of hyperkalemia is based on EKG changes, an important caveat for clinicians is that absent or atypical EKG changes do not exclude the necessity for immediate intervention. Once an urgent situation has being handled with intravenous push of a 10% calcium salt, the initiation of short-term measures can be launched by either a single or combined regimen of the three agents that cause a transcellular shift of potassium - insulin with glucose, beta(2)-agonist (albuterol), and NaHCO(3). As the first choice among these available options, we favor an intravenous bolus of 10 units of insulin with 50 ml of 50% glucose alone or in combination with 10-20 mg of albuterol by nebulizer. These can be repeated as required until the institution of hemodialysis. The combination of insulin with glucose and NaHCO(3) as an another option needs further clarification for its additive effects. However, NaHCO(3) has lost its favor because of its poor efficacy as a potassium-lowering agent when used alone. The next step is to remove potassium from the body - diuretics (furosemide), cation exchange resin (kayexelate) with sorbitol, and dialysis (preferably hemodialysis). The final important step for the managements of hyperkalemia is a long-term plan to prevent its recurrence or worsening. In addition to every effort to elucidate underlying causes and pathophysiologic mechanisms for hyperkalemia, an extensive search must be made to uncover overt or sometimes covert medications that may have led to the development of hyperkalemia. Furthermore, one must obtain detailed dietary and medical history of hyperkalemic patients.
Microstructure of Selected Binary Food Powder Mixtures (1985)

ABSTRACT Binary mixtures of sugar, citric acid, malic acid, soy protein and starch, after exposure to various relative humidities, were analyzed by Scanning Electron Microscopy (SEM). It is shown that depending on interparticle surfaceaffinity, concentration and relative humidity, the mixtures could be random, partially random, ordered or partially ordered. The type of bridging, between the aggregated particles depended on their chemical species and the availability of surface moisture.
Coreactant hydroxyalkyl phosphate catalysts for hydroxymelamine high-solids coatings (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCoreactant hydroxyalkyl phosphate catalysts for hydroxymelamine high-solids coatingsMohinder S. ChatthaCite this: Ind. Eng. Chem. Res. 1987, 26, 12, 2495–2497Publication Date (Print):December 1, 1987Publication History Published online1 May 2002Published inissue 1 December 1987https://pubs.acs.org/doi/10.1021/ie00072a018https://doi.org/10.1021/ie00072a018research-articleACS PublicationsRequest reuse permissionsArticle Views54Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Supplementary Data from Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes (2023)

&lt;p&gt;Supplementary Figures and Legends&lt;/p&gt;
Once-daily topical brimonidine tartrate gel 0·5% is a novel treatment for moderate to severe facial erythema of rosacea: results of two multicentre, randomized and vehicle-controlled studies (2011)

Once-daily BT gel 0·5% is well tolerated and provides significantly greater efficacy than vehicle gel for the treatment of moderate to severe erythema of rosacea.
Development of human B-lymphocyte targeted bi-specific DART® molecules for the treatment of autoimmune disorders (THER5P.830) (2014)

Abstract B-cell targeted immunotherapy for autoimmune disorders is often limited by general immune suppression caused by significantly altered B-cell homeostasis. To overcome this, we developed MGD010, a bi-specific Dual-Affinity Re-Targeting (DART) molecule that coligates the inhibitory Fcγ receptor IIb (CD32B) and the B-cell receptor component, CD79B, on B cells. Previous work has shown that CD32BxCD79B DARTs engage CD32B in a BCR-dependent manner and inhibit B-cell activation without B-cell depletion. MGD010, a CD32BxCD79B DART bearing an Fc domain to enhance pharmacokinetic (PK) properties, was generated to support potential clinical development. Favorable PK properties and lack of safety signals, including no cytokine release nor B-cell depletion, were observed in non-human primate dose-escalated with MGD010 to up to 10 mg/kg. Pharmacodynamic analysis demonstrated dose-correlated target binding to B cells and reduced B-cell calcium flux induced by ex vivo BCR-crosslinking. In addition, MGD010 blocked B-cell function ex vivo in samples from autoimmune patients. Repeat administration of MGD010 also inhibited both humoral immune responses and the development of chronic graft-versus-host disease in a humanized mouse model. Thus, MGD010, an Fc-bearing CD32BxCD79B DART with extended PK, may represent a promising B-cell intervention strategy for the treatment of autoimmune diseases, with limited impact on B-cell homeostasis.
Visual Investigation Using Circular Partitioning of Abstract Images (2003)

Abstract. This paper presents a novel approach for sketch-based image retrieval based on low-level features. The approach enables measuring the similarity between a full color image and a simple black and white sketched query and needs no cost intensive image segmentation. The proposed method can cope with images containing several complex objects in an inhomogeneous background. Two abstract images are obtained using strong edges of the model image and thinned images is used to extract new compact and effective features. The extracted features are scale and rotation invariant and tolerate small translations. The major contribution of the paper is in rotation invariance property of the proposed approach. A collection of paintings and sketches (ART BANK) is used for testing the proposed method. The results are compared with three other well-known approaches within the literature. Experimental results show signi£cant improvement in the Recall ratio using the proposed features. 1
Infection of Mice, Ferrets, and Rhesus Macaques with a Clinical Mumps Virus Isolate (2013)

In recent years, many mumps outbreaks have occurred in vaccinated populations worldwide. The reasons for these outbreaks are not clear. Animal models are needed to investigate the causes of outbreaks and to understand the pathogenesis of mumps virus (MuV). In this study, we have examined the infection of three animal models with an isolate of mumps virus from a recent outbreak (MuV-IA). We have found that while both ferrets and mice generated humoral and cellular immune responses to MuV-IA infection, no obvious signs of illness were observed in these animals; rhesus macaques were the most susceptible to MuV-IA infection. Infection of rhesus macaques via both intranasal and intratracheal routes with MuV-IA led to the typical clinical signs of mumps 2 weeks to 4 weeks postinfection. However, none of the infected macaques showed any fever or neurologic signs during the experimental period. Mumps viral antigen was detected in parotid glands by immunohistochemistry (IHC). Rhesus macaques represent the best animal model for the study of mumps virus pathogenesis.
A statistical theory of flow stress and work-hardening (1966)

Abstract The consequences of a random distribution of point-like obstacles to the movement of dislocations are examined. Firstly, it is proven that a critical applied stress exists; it is determined by a critical value of the fraction of passable obstacles such that the average dislocation segment can keep moving. There is thus no limit to the expandability of a convex dislocation loop; however, the moving dislocation leaves debris behind in the form of concave loops around areas surrounded entirely by impassable obstacles. The rate of this primary dislocation storage with strain, if one considers monopoles only, is very low and again depends on the critical fraction of passable obstacles only, not on any properties of the distribution as long as it is non-singular. The absence of large-scale regularity in the obstacle structure alone (whatever the nature of the obstacles may be) can thus explain “stage II” hardening which is characterized by a value of about 1/300 of the shear modulus, independent of all conceivable parameters within wide limits. The structure of the work-hardened crystal derived in this semi-phenomenological way consists of small concave loops piled up around each other and presumably arranged in strands perpendicular to the slip plane. It offers itself for appealing mechanistic interpretations of more complicated phenomena such as latent hardening, dynamic recovery, and some metallographic observations.