gebhart/patrepeval huggingface dataset:
Opdragelsens filosofi: Jean-Jacques Rousseau, Immanuel Kant, Søren Kierkegaard, Friedrich Nietzsche og John Dewey om kunsten at opdrage (2016)

Bogen giver en indføring i en række filosoffers syn på den moderne pædagogik som kunsten at opdrage. Dette omfatter Jean-Jacques Rousseau, Immanuel Kant, Søren Kierkegaard, Friedrich Nietzsche og John Dewey, hvis idéer ikke alene kan sammenfattes under begrebet 'opdragelsens filosofi', men som også omfatter idéer om den filosofiske opdragelse
Biochemistry and Biophysics of the Pancreatic B-cell (1980)

info:eu-repo/semantics/published
No Evidence that Ongoing HIV-Specific Immune Responses Contribute to Persistent Inflammation and Immune Activation in Persons on Long-Term ART (2021)

Abstract Background People with HIV (PWH) have persistently elevated levels of inflammation and immune activation despite suppressive antiretroviral therapy (ART), with specific biomarkers showing associations with non-AIDS-defining morbidities and mortality. We investigated the potential role of the HIV-specific adaptive immune response, which also persists under ART, in driving levels of these clinically relevant biomarkers. Methods HIV-specific T-cell responses and antibody concentrations were measured at study entry in the ACTG A5321 cohort, following a median of 7 years of suppressive ART. HIV persistence measures including cell-associated (CA)-DNA, CA-RNA, and plasma HIV RNA (single-copy assay) were also assessed. Plasma inflammatory biomarkers and T-cell activation and cycling were measured at a pre-ART time point and at study entry. Results Neither the magnitudes of HIV-specific T-cell responses nor HIV antibody levels were correlated with levels of the inflammatory or immune activation biomarkers, including hs-CRP, IL-6, neopterin, sCD14, sCD163, %CD38 + HLA-DR + CD8 + and CD4 + cells, and %Ki67 + CD8 + and CD4 + cells – including after adjustment for pre-ART biomarker level. Magnitudes of T-cell responses to HIV-Pol were correlated with TNF-α levels, but this was confounded by several factors. Plasma HIV RNA levels were correlated with CD8 + T-cell activation (r = 0.25, p = 0.027), but other HIV persistence parameters were not associated with these biomarkers. In mediation analysis, relationships between HIV persistence parameters and inflammatory biomarkers were not influenced by either HIV-specific T-cell responses or antibody levels. Conclusions Adaptive HIV-specific immune responses do not appear to contribute to the elevated inflammatory and immune activation profile associated with morbidity and mortality under long-term ART. Summary HIV-specific T-cell and antibody responses persist over years of suppressive ART, but there is no evidence that these ongoing immune responses contribute to elevated levels of inflammation and immune activation in people living with HIV on long-term ART.
Molecular Dynamics of Channelrhodopsin at the Early Stages of Channel Opening (2015)

Channelrhodopsin (ChR) is a light-gated cation channel that responds to blue light. Since ChR can be readily expressed in specific neurons to precisely control their activities by light, it has become a powerful tool in neuroscience. Although the recently solved crystal structure of a chimeric ChR, C1C2, provided the structural basis for ChR, our understanding of the molecular mechanism of ChR still remains limited. Here we performed electrophysiological analyses and all-atom molecular dynamics (MD) simulations, to investigate the importance of the intracellular and central constrictions of the ion conducting pore observed in the crystal structure of C1C2. Our electrophysiological analysis revealed that two glutamate residues, Glu122 and Glu129, in the intracellular and central constrictions, respectively, should be deprotonated in the photocycle. The simulation results suggested that the deprotonation of Glu129 in the central constriction leads to ion leakage in the ground state, and implied that the protonation of Glu129 is important for preventing ion leakage in the ground state. Moreover, we modeled the 13-cis retinal bound; i.e., activated C1C2, and performed MD simulations to investigate the conformational changes in the early stage of the photocycle. Our simulations suggested that retinal photoisomerization induces the conformational change toward channel opening, including the movements of TM6, TM7 and TM2. These insights into the dynamics of the ground states and the early photocycle stages enhance our understanding of the channel function of ChR.
Photoinduced Anisotropic Assembly of Conjugated Polymers in Insulating Polymer Blends (2015)

Low-dose UV irradiation of poly(3-hexylthiophene) (P3HT)-insulating polymer (polystyrene (PS) or polyisobutylene (PIB)) blend solutions led to the formation of highly ordered P3HT nanofibrillar structures in solidified thin films. The P3HT nanofibers were effectively interconnected through P3HT islands phase-separated from insulating polymer regions in blend films comprising a relatively low fraction of P3HT. Films prepared with a P3HT content as low as 5 wt % exhibited excellent macroscopic charge transport characteristics. The impact of PS on P3HT intramolecular and intermolecular interactions was systematically investigated. The presence of PS chains appeared to assist in the UV irradiation process of the blend solutions to facilitate molecular interactions of the semiconductor component, and to enhance P3HT chain interactions during spin coating because of relatively unfavorable P3HT–PS chain interactions. However, P3HT lamellar packing was hindered in the presence of PS chains, because of favorable hydrophobic interactions between the P3HT hexyl substituents and the PS chains. As a result, the lamellar packing d-spacing increased, and the coherence length corresponding to the lamellar packing decreased, as the amount of PS in the blend films increased.
Omnidirectional Linearly and Circularly Polarized Rectangular Dielectric Resonator Antennas (2011)

The rectangular dielectric resonator antenna (DRA) centrally fed by a probe is investigated. Its operating mode is analogous to the <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TM</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">011</sub> mode of a cylindrical DRA. The DRA radiates like an electric monopole, generating omnidirectional linearly polarized (LP) fields. Based on this LP design, a novel omnidirectional circularly polarized (CP) DRA is studied for the first time. Slots are introduced to the sidewalls of the DRA, exciting a degenerate mode for the generation of CP fields. To demonstrate the idea, an omnidirectional CP DRA was designed for WLAN (2.4-2.48 GHz) applications. The reflection coefficient, axial ratio (AR), radiation pattern, and antenna gain are studied, and reasonable agreement between the measured and simulated results is observed.
Effect of sRNA and Related Compounds on the Phosphorolysis of Polynucleotide Phosphorylase in the Degradation of Messenger Ribonucleic Acids (1966)

Journal Article Effect of sRNA and Related Compounds on the Phosphorolysis of Polynucleotide Phosphorylase in the Degradation of Messenger Ribonucleic Acids Get access MASAMITSU FUTAI, MASAMITSU FUTAI Faculty of Pharmaceutical Sciences, University of TokyoBunkyo-ku, Tokyo Search for other works by this author on: Oxford Academic PubMed Google Scholar DEN’ICHI MIZUNO DEN’ICHI MIZUNO Faculty of Pharmaceutical Sciences, University of TokyoBunkyo-ku, Tokyo Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Biochemistry, Volume 59, Issue 5, May 1966, Pages 521–523, https://doi.org/10.1093/oxfordjournals.jbchem.a128336 Published: 01 May 1966 Article history Received: 10 January 1966 Published: 01 May 1966
Ten-Year Trends in Fiber and Whole Grain Intakes and Food Sources for the United States Population: National Health and Nutrition Examination Survey 2001–2010 (2015)

Current U.S. dietary guidance includes recommendations to increase intakes of both dietary fiber and whole grain (WG). This study examines fiber and WG intakes, food sources and trends from 2001 to 2010 based on National Health and Nutrition Examination Survey (NHANES) data for children/adolescents (n=14,973) and adults (n=24,809). Mean fiber intake for children/adolescents was 13.2 (±0.1) g/day. Mean fiber intake for adults 19-50 years (y) was 16.1 (±0.2) g/day and for adults 51+ was 16.1 (±0.2) g/day. There were significant increases in fiber intake from 2001-2010 for children/adolescents and for adults 51+y. Mean WG intake for children/adolescents was 0.52 (±0.01) oz eq/day. Mean WG intake for adults 19-50 y was 0.61 (±0.02) oz eq/day and for adults 51+0.86 (±0.02) oz eq/day. There were no significant changes in WG intake for any age group from 2001-2010. The main food groups contributing to dietary fiber intake for children/adolescents were vegetables (16.6%), grain mixtures (16.3%), other foods (15.8%) and fruits (11.3%). For adults 19+y, the main sources of dietary fiber were vegetables (22.6%), other foods (14.3%), grain mixtures (12.0%) and fruits (11.1%). Major WG sources for children/adolescents included ready-to-eat cereals (RTEC) (31%), yeast breads/rolls (21%) and crackers and salty grain snacks (21%). The main sources of WG for adults 19+ were yeast breads/rolls (27%), RTEC (23%) and pastas/cooked cereals/rice (21%). Recommending cereals, breads and grain mixtures with higher contents of both dietary fiber and WG, along with consumer education, could increase intakes among the United States (U.S.) population.
The UAS control segment architecture: an overview (2013)

The Under Secretary of Defense (Acquisition, Technology and Logistics) directed the Services in 2009 to jointly develop and demonstrate a common architecture for command and control of Department of Defense (DoD) Unmanned Aircraft Systems (UAS) Groups 2 through 5. The UAS Control Segment (UCS) Architecture is an architecture framework for specifying and designing the softwareintensive capabilities of current and emerging UCS systems in the DoD inventory. The UCS Architecture is based on Service Oriented Architecture (SOA) principles that will be adopted by each of the Services as a common basis for acquiring, integrating, and extending the capabilities of the UAS Control Segment. The UAS Task Force established the UCS Working Group to develop and support the UCS Architecture. The Working Group currently has over three hundred members, and is open to qualified representatives from DoD-approved defense contractors, academia, and the Government. The UCS Architecture is currently at Release 2.2, with Release 3.0 planned for July 2013. This paper discusses the current and planned elements of the UCS Architecture, and related activities of the UCS Community of Interest.
Continuations in hardware-software codesign (2002)

This paper presents a case study for using high-level programming techniques to support the migration of software into hardware. The example is a derived implementation of a symbolic processing machine. The design environment employs codesign to maintain consistency between an executable software model of the system and the individual hardware components that are extracted from it. The presentation focuses on the use of continuations to move from a procedural view of memory allocation to a process view. Our previous work has used functional models as a source for correct hardware derivation using a transformational algebra. The work reported will result in extensions that deal more powerfully with the factorization of sequential subsystems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Electric Vehicle Intelligent Control System-Hardware modules configurations (2012)

The Electric Vehicle Intelligent Control System(EVICS) project where the EVICS is a 2-in-1 system for an Electric Vehicle(EV) which consist of Monitoring System for the front seat driver and Infotainment System for the rear seat passengers. The Monitoring system consist of battery voltage, current and temperature monitoring modules, battery energy status(%), distance left(km), km/h and rpm meter, offline and online Global Positioning System(GPS) and Contour Positioning System(CPS). The Infotainment System consist of music and movie player, internet and web streaming (Google), social networking applications (Facebook, Twitter, LinkedIn, Blogspot), games (Angry Birds), video streaming (Youtube), and many more. The Infotainment System can also be implemented into the conventional engine cars.
Corpus-based Content Construction (2018)

Enterprise content writers are engaged in writing textual content for various purposes. Often, the text being written may already be present in the enterprise corpus in the form of past articles and can be re-purposed for the current needs. In the absence of suitable tools, authors manually curate/create such content (sometimes from scratch) which reduces their productivity. To address this, we propose an automatic approach to generate an initial version of the author’s intended text based on an input content snippet. Starting with a set of extracted textual fragments related to the snippet based on the query words in it, the proposed approach builds the desired text from these fragment by simultaneously optimizing the information coverage, relevance, diversity and coherence in the generated content. Evaluations on standard datasets shows improved performance against existing baselines on several metrics.
Dynamic Maximum Entropy algorithms for clustering and coverage control (2010)

The dynamic coverage problem is increasingly found in a wide variety of areas, for example, from the development of mobile sensor networks, to the analysis of clustering in spatio-temporal dynamics of brain signals. In this paper, we apply control-theoretic methods to locate and track cluster center dynamics and show that dynamic control design is necessary to achieve dynamic coverage of mobile objects under acceleration fields. This is the first work to consider tracking cluster centers when site dynamics involve accelerations. We focus on the relationship between the objective of maximizing coverage in real-time and the Maximum Entropy Principle, and develop the ability to identify inherent cluster dynamics in a dataset. Algorithms are presented that guarantee asymptotic tracking of cluster centers, and for which we prove continuity and boundedness of the corresponding control laws. Simulations are provided to corroborate these results.
Increased erythropoietin production in anephric rats with hyperplasia of the reticuloendothelial system induced by colloidal carbon or zymosan (1976)

Abstract Adult rats were subjected sequentially to (1) administration of colloidal carbon, zymosan, or gadolinium; (2) subtotal hepatectomy, bilateral nephrectomy, or sham operation; and (3) a 6-hr bout of hypoxia, starting 1 hr or 24 hr after the operation. Control animals received the respective vehicles. The erythropoietin (Ep) activity was assayed in exhypoxic polycythemic mice on the basis of 48-hr per cent RBC(-59) Fe incorporation values. Ep levels in serum of anephric rats primed with either colloidal carbon or zymosan were considerably more elevated than in control animals. This potentiating effect was observed in rats subjected to hypoxia starting either 1 or 24 hr after nephrectomy. On the other hand, gadolinium did not enhance the extrarenal Ep response to hypoxia. It is emphasized that both colloidal carbon and zymosan induced marked hyperplasia of the hepatic and splenic reticuloendothelial system (RES), while gadolinium did not induce this effect. A strict correlation was thus established between potentiation of extrarenal Ep production and hyperplasia of the RES. It is therefore tentatively concluded that the RES is a source of extrarenal Ep. Additionally, since the liver plays a prominent role in extrarenal Ep production, Kupffer cells may represent a major source for Ep in the anephric rat. Finally, it is of interest that both colloidal carbon and zymosan did not potentiate the Ep response to hypoxia in sham-operated or subtotally hepatectomized rats.
Competitive tracking of molecular objectives described by quantum mechanics (1995)

The control of molecular events by optical fields is sought with the methods of asymptotic inverse tracking, local track generation (model matching), and competitive tracking which are extensions of exact inverse tracking. The methodology is applied to infrared dissociation of a diatomic molecule and selective dissociation of the stronger bond in a highly coupled linear triatomic system. The major appeal of these methods is that they do not require costly iterations unlike other control studies in which optimization techniques are used to design fields to achieve desired molecular objectives. It is found that in exact inverse tracking where a requisite external field is obtained to exactly track a prescribed objective expectation value as a function of time, a high degree of intuition is required to find an a priori objective track such that the required fields are reasonable in terms of intensity and bandwidth. Furthermore, exact inverse tracking does not allow for tracking of multiple observables. The extensions of the inverse tracking method presented in this work help to alleviate these drawbacks. In all of these extensions the requisite field is computed locally in time through minimization of a cost functional which contains terms designed to minimize the error between the objective and actual tracks and also minimize the field fluence. The objective tracks can be prescribed a priori as in exact inverse tracking or from the present evolving system state (local track generation). Competitive tracking allows for the following of multiple observables although none will be tracked exactly. Locally generated tracks (model matching) require less physical intuition because it is easier to specify an objective track with current knowledge of the state of the system. However, the tradeoff with this method is that prediction of the behavior of the tracked observables may be elusive.
Mild Traumatic Brain Injury Induces Time- and Sex-Dependent Cerebrovascular Dysfunction and Stroke Vulnerability (2022)

Mild traumatic brain injury (mTBI) produces subtle cerebrovascular impairments that persist over time and promote increased ischemic stroke vulnerability. We recently established a role for vascular impairments in exacerbating stroke outcomes 1 week after TBI, but there is a lack of research regarding long-term impacts of mTBI-induced vascular dysfunction, as well as a significant need to understand how mTBI promotes stroke vulnerability in both males and females. Here, we present data using a mild closed head TBI model and an experimental stroke occurring either 7 or 28 days later in both male and female mice. We report that mTBI induces larger stroke volumes 7 days after injury, however, this increased vulnerability to stroke persists out to 28 days in female but not male mice. Importantly, mTBI-induced changes in blood-brain barrier permeability, intravascular coagulation, angiogenic factors, total vascular area, and glial expression were differentially altered across time and by sex. Taken together, these data suggest that mTBI can result in persistent cerebrovascular dysfunction and increased susceptibility to worsened ischemic outcomes, although these dysfunctions occur differently in male and female mice.
Chirp pulse compression in non-coherent Impulse-Radio Ultra-Wideband detection without waveform signature estimation (2012)

The paper investigates benefits of using chirp pulse compression in non-coherent Impulse-Radio Ultra-Wideband (IR-UWB) communications. Furthermore, we develop closed form expression for bandwidth and dimension of the signal after the chirp pulse compression that was lacking before. Two usual types of non-coherent IR-UWB detection are considered — energy detection of PPM-modulated symbols and sample-wise differential detection of DPSK-modulated symbols. These detection schemes show deterioration of bit error probability performance with an increase of the dimension of the signal in detection. The performance of the aforementioned detection schemes improves significantly when chirp pulse compression is applied, i.e. when dimension of the signal in detection is reduced. As we show, this performance enhancement happens in noise as well as in multi-user interference.
Knudsen effusion through polymer-coated three-layer porous graphene membranes (2017)

Graphene membranes have the potential to exceed the permeance and selectivity limits of conventional gas separation membranes. Realizing this potential in practical systems relies on overcoming numerous scalability challenges, such as isolating or sealing permeable defects in macroscopic areas of graphene that can compromise performance and developing methods to create high densities of selective pores over large areas. This study focuses on a centimeter-scale membrane design, where leakage is reduced by substrate selection, permeable polymer film coating, and stacking of three independent layers of graphene, while (selective) pores are created by high density ion bombardment. The three-layer graphene provides high resistance to gas flow, which decreases with ion bombardment and results in selectivity consistent with Knudsen effusion. The results suggest that the permeable pores created in three layer graphene were larger than those required for molecular sieving and that designs based on single layer graphene may lend themselves more easily to molecular sieving of gases.
Corrigendum (1982)

Y. Mori, M. Tsuboi, M. Suzuki, K. Fukushima and T. Arai, J. Chem. Soc., Chem. Commun., 1982, 472 DOI: 10.1039/C39820000472
Structural origin of broken chemical order in a GeSe2glass (1982)

Two clearly defined and chemically inequivalent Sn sites in the alloy glass (${\mathrm{Ge}}_{0.99}$${\mathrm{Sn}}_{0.01}$)${\mathrm{Se}}_{2}$ are observed using M\"ossbauer spectroscopy. These sites are identified with Sn impurity atoms replacing Ge in tetrahedral ${\mathrm{G}\mathrm{e}({\mathrm{Se}}_{1/2})}_{4}$ units and ethanelike ${{\mathrm{Ge}}_{2}({\mathrm{Se}}_{1/2})}_{6}$ units, and provide direct evidence for intrinsically broken Ge chemical order. Compositional variation of site intensities shows that the origin of this broken order derives from the existence of characteristic clusters in the network.