gebhart/patrepeval huggingface dataset:
The Current Status of Gene Therapy in Autologous Transplantation (2005)

Autologous hematopoietic cells have been used as targets of gene transfer, with applications in inherited disorders, cell therapy, and acquired immunodeficiency. The types of cells include hematopoietic progenitor cells, lymphocytes, and mesenchymal stem cells. The inherited disorders thus far approached in clinical trials include severe combined immunodeficiency, common variable gamma-chain immunodeficiency, chronic granulomatous disease, and Gaucher disease. Preclinical studies are vigorously under way in thalassemia, sickle cell anemia, Wiskott-Aldrich syndrome and Fanconi anemia. Clinical trials of immunological therapy with gene-modified lymphocytes are under study in the treatment of malignancies. Clinical trials using anti-viral strategies for HIV infection in combination with autologous transplantation have begun, with additional approaches being developed. Gene therapy vectors are being developed to eliminate tumor cells contaminating autologous stem cell products. However, the risk of insertional mutagenesis and the potential for development of leukemia was highlighted by the first gene therapy trials in inherited immunodeficiency syndromes that achieved a therapeutic effect. Despite the slow progress of the field to date, there is extraordinary promise for gene therapy in the future.
Spontaneous formation of hierarchical proton‐conductive structures in sulfonated poly(p‐phenylene terephthalamide) copolymer films (2007)

Abstract Two partially sulfonated copolymers of poly( p ‐phenylene terephthalamide) were studied; the sulfonated diamine to nonsulfonated diamine ratios were x = 1 and x = 2. Polymer solutions in water demonstrated lyotropic liquid‐crystalline behavior, with the critical concentration for nematic phase formation being around 0.7 wt %. Films of these copolymers could be considered for fuel‐cell applications. The in‐plane proton conductivities were of the order of 10 −3 to 10 −2 S cm −1 between 20 and 90 °C. Increasing the sulfonation level resulted in a more conductive material. Spontaneous alignment of the polymer occurred during film formation, as revealed by X‐ray diffraction. Scattering along the polymer backbone was observed perpendicular to the film, implying that the polymer chains were homeotropically aligned with respect to the film. The average degree of alignment was determined to be 0.66 and 0.77 for x = 1 and x = 2, respectively. Evidence of secondary layering within the plane of the film was seen in SEM images. These layers could provide a pathway for proton conduction to occur within the plane of the film. © 2007 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 45: 666–676, 2007
Synthèse et réactivité d'aziridines substituées par un groupe trifluorométhyle (1987)

Synthese par reaction d'organomagnesiens avec des oximes substituees par un groupe trifluomethyl. La reactivite de ces aziridines a ete etudiee afin de preparer des produits substitues par un groupement trifluoromethyle. L'action de l'iodure de sodium sur certains derives n-acyles de ces aziridines a permis de synthetiser regio- et diastereo-specifiquement des oxazolines, des oxazolidinones et des amides ou carbamates ethyleniques. Des alpha -halogeno trifluoromethylamines ont ete preparees par action d'hydracides sur ces aziridines secondaires. En milieu anhydre, un seul diastereoisomere a ete obtenu, alors qu'en milieu aqueux, un melange de diastereoisomeres s'est forme. Par action d'acide sulfurique, on a pu synthetiser des alpha -hydroxy trifluoromethylamides. La thermolyse des aziridines secondaires a conduit a des imines provenant de la formation intermediaire d'ylure d'azomethine. Activites biologiques des composes prepares
Effect of Interleukin-1 Blockers, CK112, and CK116 on Rat Experimental Choroidal Neovascularization In Vivo and Endothelial Cell Cultures In Vitro (2006)

CK112 and CK116 inhibited the development of CNV in the rat model and interfered with vascular endothelial cell proliferation in vitro. Our results suggest that CK112 and CK116 may be good candidates to inhibit ocular neovascularization related to age-related macular degeneration (ARMD).
Role of cephalosporinase in carbapenem resistance of clinical isolates of Pseudomonas aeruginosa (1993)

With numerous imipenem-resistant clinical isolates of Pseudomonas aeruginosa as well as in vitro-selected resistant mutants, we have demonstrated, by a simple method with a powerful cephalosporinase inhibitor, BRL42715, the contribution of chromosomal cephalosporinase in resistance to imipenem in this species.
Expression of neuronal nitric oxide synthase in PDGF-hAPP transgenic mice (2006)

The major histopathological finding in the Alzheimer’s disease (AD) brain is the presence of neuritic plaques containing β-amyloid (Aβ). In addition some findings showed an alteration of nitric oxide pathway in AD patients. PDGF-hAPP mice, an animal model of AD, deposit Aβ in age-dependent manner, were used as. In this study, we investigated the neuronal nitric oxide synthase (nNOS) expression in the cortex of transgenic PDGF-hAPP mice comparing with C57BL/6 control. We also detected neu-ropeptide Y (NPY), known to be co-localised with NOS in cortical neurons, and neuN, a neuronal marker. Our results showed a significant decrease in the number of nNOS positive neurons in the cortex of transgenic mice respect to control. NADPH-d/NPY double staining showed that almost all nitroxidergic neurons were co-localized with NPY and that several neurons were only NPY positive. Respect to control, transgenic mice showed a decrease of NADPH-d/NPY double stained neurons and an apparent increase of NPY single stained neurons. The total number of neuN positive neurons was similar in both groups, suggesting that in some double stained neurons there was a nNOS down-regulation but that the neurons survived expressed only NPY. These data support that nitroxidergic system is impaired in this AD animal model.
Preliminary screening of flow behavior around airfoils using a microphone phased array (2008)

Recently, as a part of research projects for the National Renewable Energy Laboratory (NREL) and Sandia National Laboratories, several full-scale, wind-turbine airfoils were tested at various speeds (high Reynolds numbers) and angles of attack in the Virginia Tech Stability Wind Tunnel. This unique facility is aerodynamically closed and acoustically open, which allows better aerodynamic performance than a free jet facility, while maintaining comparable acoustic performance. Flow measurements consisted of monitoring the surface pressure around the airfoils with a distribution of pressure taps on the airfoil surface. Acoustic measurements were carried out with a microphone phased array. The phased-array data was post-processed to generate acoustic maps of the noise generated by the airfoils exposed to the flow as well as their noise spectra. In addition to the tests, two-dimensional CFD computations of the flow field around the airfoils were carried out using a k-ε turbulent model. The acoustic maps clearly show the noise sources generated by potential turbulent flow around the airfoils. The very good correlation between the acoustic maps and the flow characteristics of the airfoils, both numerical and experimental, allows for phased-array measurements to be used as a tool for preliminary screening of the flow behavior around a given airfoil.
Significantly enhanced piezoelectric performance in Bi4Ti3O12-based high-temperature piezoceramics via oxygen vacancy defects tailoring (2020)

Bismuth titanate (Bi4Ti3O12, BIT) piezoelectric materials have attracted increasing attention due to their high-temperature applications. However, it is quite challenging to simultaneously achieve outstanding piezoelectric properties and high Curie temperature in BIT-based systems. In this study, oxygen vacancy defects tailoring strategy was utilized to solve this problem, excellent piezoelectric coefficient (32.1 pC/N), and ultrahigh Curie temperature (659 °C) are gotten in Bi4Ti3-x(Mn1/3Nb2/3)xO12 (BTMN) ceramics, which are among the top values in the BIT-based ceramics. More importantly, the (Mn1/3Nb2/3)(4+δ)+ complex-ion modified Bi4Ti3O12-based ceramics are characterized with excellent piezoelectric stability up to 500 °C (d33 > 30.0 pC/N at 500 °C)) and significantly reduced conductivity (only ∼ 10−7 Ω−1 cm−1 at 500 °C). Moreover, enhanced ferroelectricity and good dielectric stability were also obtained. The better comprehensive properties can be ascribed to two aspects. First, the concentration of oxygen vacancy defects is obviously reduced, and their distribution is effectively controlled in BITMN ceramics. Second, the introduction of (Mn1/3Nb2/3)(4+δ)+ complex-ion gives rise to the antiphase boundaries and massive ferroelectric domain walls. This works not only reveal the high potential of BITMN ceramics for high-temperature piezoelectric applications but also deepen the understanding of the structure-properties relationship in BIT-based materials.
Nonlinear models of TWT revisited for OFDM systems (2002)

Recently, OFDM systems have received wide interest, particularly in the field of terrestrial broadcasting of all digital television in the UHF/VHF bands. The use of TWT (Traveling Wave Tubes) is considered for the final amplification of the OFDM signal. The OFDM modulated signal is very close to a Gaussian random process. In this paper we revisit the most popular TWT models and recognize that they belong to a peculiar class of non-linearities, S/spl times/FSM, in which the output is the product of the incoming complex signal and a function of its modulus. For S/spl times/FSM nonlinearities, driven by a Gaussian input, output statistics can be evaluated in closed forms. We apply this analysis to the TWT non-linearity, deriving the power spectral density of the output signal as well as the probability density function, when the input is an OFDM signal.
Dynamics of the Quenching and Partitioning (Q&P) Process (2011)

The novel heat treatment concept of Quenching and Partitioning (Q&amp;P) offers exciting prospects for the production of higher strength steel products with enhanced formability from a microstructure containing retained austenite and martensite. The Q&amp;P process hinges on an interrupted quench and partitioning step at intermediate temperatures whereby the untransformed austenite can be thermodynamically stabilised by enrichment of carbon from the supersaturated martensite. Although the concept is similar to that producing carbide-free bainite in TRIP-assisted steel, Q&amp;P offers the advantage of separating the ferrite formation and austenite enrichment stages of the process. While the concept is readily understood, the details of microstructural evolution during interrupted quenching and partitioning steps are difficult to study and are generally inferred from dilatometry or metallographic examination after a final quench back to room temperature. Consequently, in this study, alloying has been used to develop a model alloy in which the sequential steps of heat treatment can be separated for closer, more direct inspection by neutron diffraction techniques.
Low Pressure Koch Reaction by Cu(CO)n+-H2SO4-H3PO4-H2O Catalyst(Part 4). Structural Analysis of Branched tert-Nonanoic Acids in the Low Pressure Koch Reaction of Branched Octenes. (1994)

Cu(CO)n+-H2SO4-H3PO4-H2O触媒を用いた2種の分岐オクテン (ジイソブチレンとブテンダイマー) の低圧コッホ反応において反応物の分岐オクテンと生成物の分岐三級ノナン酸の構造解析をGC-MSとNMRにより行った。分岐三級ノナン酸の三つのアルキル基はGC-MSスペクトルに McLafferty 転位由来のフラグメントイオンが強く検出されるため, かなりの精度で推定できた。構造解析の結果, 分岐オクテンの低圧コッホ反応により得られるカルボン酸はほぼ100%三級であること, および全17の三級ノナン酸のうち, 13成分の検出を確認した。また, ジイソブチレン含有量 (2,4,4-トリメチルペンテン) のかなり異なる分岐オクテンを反応させても, 2,2,4,4-テトラメチルペンタン酸等を除くとほとんど似た組成の三級ノナン酸混合物が得られることを確認した。これはカルボキシル化が触媒中において骨格異性化を経て起こるためと説明された。
Campylobacter fetus meningitis confirmed by a 16S rRNA gene analysis using the MinION nanopore sequencer, South Korea, 2016 (2017)

Emerging Microbes & Infections (2017) 6, e94; doi:10.1038/emi.2017.81; published online 1 November 2017
ChemInform Abstract: INTRAMOLECULAR PHOTO ENE‐REACTION AS A CONCURRENT STEP IN (2+2) CYCLOADDITIONS (1979)

Abstract (IIIk) oder (IVd) nachgewiesen werden.
<title>Nonuniformity correction of, and calibrated projection with, a resistor array infrared scene projector</title> (1995)

Kinetic energy weapon (KEW) programs under the Ballistic Missile Defense Office (BMDO) need high fidelity, fast framing infrared (IR) imaging seekers. As imaging sensors have matured to support BMDO, the complexity of functions assigned to the KEW weapon systems has amplified the necessity for robust hardware-in-the-loop (HWIL) simulation facilities to reduce program risk. The IR projector, an integral component of a HWIL simulation, must reproduce the real world with enough fidelity that the unit under test's (UUT) software will respond to the projected scenario of images as though it were viewing the real world. The CMOS resistor array IR scene projector, a wideband flickerless technology, shows great promise in cryogenic vacuum chamber as well as room temperature testing. A 128 X 128 CMOS resistor array has undergone extensive characterization measurements at Eglin AFB to determine its potential for HWIL testing of BMDO IR seekers. This paper addresses the nonuniformity correction (NUC) and use of the array in a calibrated projection test. The methodology and process for the NUC is described. Sensitivities to such things as output averaging, and optical sampling are explained. With the NUC procedure established, a test was accomplished that provided calibrated scene radiance values to a UUT. Absolute radiance values were not projected. Rather, the array's low and high output capabilities were equated to the low and high radiance values of an input scene. A calibration curve was established that allowed the UUT's output to be equated to the input scene's radiance values. The input scene was projected to the UUT, and the scene's radiance values were reproduced after applying the calibration curve to the UUT's output response. To the authors' knowledge, this if the first accomplishment of such a test with a dynamic IR scene projector.
Biopsia cardiaca y cateterismo derecho a través de la vena basílica (2006)

La relevancia de la descripcion de este procedimiento se justifica por el protagonismo del profesional de Enfermeria en la ejecucion del protocolo, ya que es el que realiza la canalizacion de la vena, la dilatacion y la colocacion del introductor.
El proposito de este trabajo es analizar las ventajas que aporta para el paciente la canalizacion de la vena basilica para la realizacion de cateterismos cardiacos derechos, implantacion de marcapasos temporales y realizacion de biopsias cardiacas.
En el equipo de hemodinamica en el que trabajamos, una vez familiarizado con esta tecnica, se ha podido comprobar que ofrece ventajas importantes sobre las vias de acceso previamente utilizadas, como la via yugular o la femoral. Algunas de estas ventajas son la mayor comodidad de los enfermos durante la realizacion del cateterismo y la reduccion del tiempo de ingreso hospitalario en algunos casos.
Fabrication of Porous Silicon Nitride with High Porosity (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Left Centrifugal Pump Cardiac Assist with Transseptal Percutaneous Left Atrial Cannula (1998)

Left cardiac support postcardiotomy requires a second operation for removal of the atrial cannula following weaning from assistance. To avoid the risk of this procedure, we used a transseptal cannula prototype. The cannula was introduced percutaneously through the femoral vein and advanced into the left atrium guided by the finger of the surgeon. Optimal positioning of the tip of the cannula was verified by perioperative transesophageal echocardiography. A long arterial cannula was positioned in the descending aorta via the femoral artery and a Carmeda circuit with a centrifugal pump was connected to both cannulas. This procedure was used in 3 patients with low cardiac output who underwent emergency surgery, a 63-year-old patient referred for aortic and mitral valve replacement, a 54-year-old man for aortic valve replacement, and a 64-year-old patient in the acute phase of myocardial infarction after myocardial revascularization. The assistance was used systematically at the end of the operation. The assist flow was 1.2-2.6 L/min. The patients were all weaned from support between 18 h and 8 days later. No complications related to the device occurred. Both cannulas were removed surgically from the femoral vessels without reopening the chest. This new procedure is of interest for 2 reasons: the systematic implantation allows for early assistance, and the use of a percutaneous approach avoids the risk of reopening the chest. More cases are needed to confirm this initial good impression.
Whole Exome Sequencing in a Rare Disease: A Patient with Anomalous Left Coronary Artery from the Pulmonary Artery (Bland-White-Garland Syndrome) (2016)

To the
Displacement Cascades. Dynamics and Atomic Structure (1987)

Abstract The seminal ideas of Seeger, in 1958 and 1962, on the nature of a displacement cascade (DC) in irradiated crystalline materials have played an important role in the field of radiation damage. This paper first reviews the early history of displacement spikes, replacement collision sequences (RCSs), “diluted” or depleted zones and thermal spikes. Then the use is discussed of molecular dynamics (MD) simulations and field‐ion microscopy as techniques by which one can study the dynamics of the formation of DCs and the spatial array of point defects — on an atomic scale — associated with quiescent DCs, respectively. These techniques demonstrate quantitatively that a DC consists of a vacancy‐rich core surrounded by a distribution of self‐interstitial atoms (SIAs) — the latter are predominately created by RCSs. Recent results on the application of MD to the behavior of 5 keV cascades in copper are presented. Some of the results of the application of field‐ion microscopy to the study of DCs in tungsten are reviewed, and compared with the MD results.
Effects of ultrasound on the enzymatic degradation of pectin (2021)

Ultrasound-assisted enzymatic maceration (UAEM) has gained considerable interest in the fruit juice industry, owing to its potential to increase juice yield and content of polyphenols while simultaneously saving time and energy. In this study, the effects of UAEM (ultrasonic probe, 20 kHz, 21 W*cm<sup>-2</sup> and 33 W*cm<sup>-2</sup>) on pectin degradation in a continuous circulation system were investigated over 60 and 90 min. Main pectinolytic enzymes activities of (polygalacturonase, pectin lyase and pectin methylesterase) of a commercial enzyme preparation were examined for individual synergistic effects with US. Pectin hydrolysis by UAEM differed significantly compared to treatment with ultrasound or enzymes alone regarding the profile of degradation products compared to treatment with ultrasound or enzymes alone. Ultrasound fragmented pectin to less branched oligomers of medium molecular weight (Mp approx. 150 kDa), which were further degraded by pectinolytic activities. The low molecular weight fraction (<30 kDa), which is known to be beneficial for juice-quality by adding nutritional value and stabilizing polyphenols, was enriched in small oligomers of homogalacturonan-derived, rhamnogalacturonan I-derived, and rhamnogalacturonan II-derived residues. Synergistic effects of ultrasound application enhanced the effective activities of polygalacturonase and pectin lyase and even prolonged their performance over 90 min, whereas the effective activity of pectin methylesterase was not affected. Final marker concentrations determined by each enzyme assay revealed a considerable higher total process output after UAEM treatment at reduced temperature (30 °C) comparable to the output after conventional batch maceration at 50 °C. The obtained results demonstrate the high potential of UAEM to produce high-quality juice by controlling pectin degradation while reducing process temperature and equally highlight the matrix and enzyme specific effects of a simultaneous US treatment.
Mutational analysis of the serotonin receptor 5HT2c in severe early-onset human obesity (2004)

Deletion of the serotonin receptor 5HT2c in mice results in increased food intake and obesity. We screened 95 individuals with severe early-onset obesity for mutations in the coding sequence of this gene. We found a novel missense variant c.1255A > G (Thr419Ala) in a single Caucasian subject that was not found in 192 Caucasian control subjects. In transiently-transfected COS cells, the Thr419Ala variant was indistinguishable from the wild-type receptor in its ability to generate inositol phosphate, although differences in coupling to other pathways were not excluded. Three previously unreported silent variants: IVS3 + 30G > A, IVS3 + 80C > G and IVS4 - 31A > G were found with prevalences of 11.5%, 0.5% and 17.9%, respectively. In conclusion, mutations in 5HT2c are unlikely to be a common cause of severe early-onset human obesity. The identification of several novel polymorphisms at this locus may aid future genetic epidemiological studies.
Preparation of modified hydrolysis lignin and its use for filling epoxy polymers and enhancing their flame resistance (2011)

The reaction of hydrolysis lignin with orthophosphoric acid and urea under the conditions of reactant fusion without a solvent was studied. The influence of the reactant ratio and of the reaction temperature and time on the degree of chemical binding of phosphorus and nitrogen with lignin was examined. The modification products can be used as fire-retardant fillers for epoxy compounds.