gebhart/patrepeval huggingface dataset:
Vesicular Stomatitis Virus as an Oncolytic Agent against Pancreatic Ductal Adenocarcinoma (2012)

Vesicular stomatitis virus (VSV) is a promising oncolytic agent against a variety of cancers. However, it has never been tested in any pancreatic cancer model. Pancreatic ductal adenocarcinoma (PDA) is the most common and aggressive form of pancreatic cancer. In this study, the oncolytic potentials of several VSV variants were analyzed in a panel of 13 clinically relevant human PDA cell lines and compared to conditionally replicative adenoviruses (CRAds), Sendai virus and respiratory syncytial virus. VSV variants showed oncolytic abilities superior to those of other viruses, and some cell lines that exhibited resistance to other viruses were successfully killed by VSV. However, PDA cells were highly heterogeneous in their susceptibility to virus-induced oncolysis, and several cell lines were resistant to all tested viruses. Resistant cells showed low levels of very early VSV RNA synthesis, indicating possible defects at initial stages of infection. In addition, unlike permissive PDA cell lines, most of the resistant cell lines were able to both produce and respond to interferon, suggesting that intact type I interferon responses contributed to their resistance phenotype. Four cell lines that varied in their permissiveness to VSV-ΔM51 and CRAd dl1520 were tested in mice, and the in vivo results closely mimicked those in vitro. While our results demonstrate that VSV is a promising oncolytic agent against PDA, further studies are needed to better understand the molecular mechanisms of resistance of some PDAs to oncolytic virotherapy.
A Delta-Lake System at Jezero Crater (Mars) from long distance observations (2022)

International audience
Evaluation of muscle activity on competitive wheelchairs made by 2 types of metallic material for badminton (2019)

Currently, various types of wheelchairs for badminton are developed for the purpose of weight saving and functional improvement. Furthermore, the materials of the wheelchair frame also diversity. The purpose of this study were to evaluate each performance of the two types of competitive wheelchair for badminton made by the two different metallic materials. In experiment, the electromyograms of subject from six muscles in driving each wheelchair was measured and analyzed. Furthermore, the motion in driving was captured and analyzed using the three-dimensional motion capture system. Subjects were two representatives from Japan. This experiment led to the following result; the driving performance of the wheelchair made by scandium-aluminum composite material was a slightly higher than that by magnesium composite material. This result was thought that the stiffness was more important rather than the lightness in driving badminton wheelchair.
FGF-23 and osteoprotegerin are independently associated with myocardial damage in chronic kidney disease stages 3 and 4. Another link between chronic kidney disease-mineral bone disorder and the heart (2011)

We have shown that changes in bone mediators and phosphate metabolism induced by CKD are independently associated with vascular and cardiomyocyte dysfunction. Our findings suggest that cardiac dysfunction may be specifically associated with such abnormalities in addition to recognized increases in vascular stiffness.
Venereal Transmission of Sindbis Virus Between Individuals of Aedes Australis (Diptera: Culicidae) (1984)

Journal Article Venereal Transmission of Sindbis Virus Between Individuals of Aedes Australis (Diptera: Culicidae) Get access J.R. Ovenden, J.R. Ovenden 2 1Virus Ecology Research Group, Research School of Biological Sciences, The Australian National University, Canberra, A.C.T. 2601, Australia 2Present address: Zoology Department, University of New South Wales, P.O. Box 1, Kensington, N.S.W. 2033, Australia. Search for other works by this author on: Oxford Academic PubMed Google Scholar R.J. Mahon R.J. Mahon 2 3 2Present address: Zoology Department, University of New South Wales, P.O. Box 1, Kensington, N.S.W. 2033, Australia. Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Medical Entomology, Volume 21, Issue 3, 30 May 1984, Pages 292–295, https://doi.org/10.1093/jmedent/21.3.292 Published: 30 May 1984
Phosphorylation of the glycogen‐binding subunit of protein phosphatase‐1G by cyclic‐AMP‐dependent protein kinase promotes translocation of the phosphatase from glycogen to cytosol in rabbit skeletal muscle (1986)

The glycogen-bound form of protein phosphatase-1 (termed protein phosphatase-1G) is composed of the catalytic (C) subunit complexed to a glycogen-binding (G) subunit that anchors the enzyme to glycogen [Strålfors et al. (1985) Eur. J. Biochem. 149, 295-303]. Incubation of purified protein phosphatase-1G with cyclic-AMP-dependent protein kinase and MgATP, which leads to stoichiometric phosphorylation of the G-subunit [Caudwell et al. (1986) FEBS Lett. 194, 85-90], was found to promote the release of the phosphatase from glycogen; similar observations were made using glycogen-protein particle preparations. An intravenous injection of adrenaline decreased protein phosphatase-1 activity associated with the glycogen-protein particles by 50% with a corresponding increase in the amount present in the cytosol. By contrast, adrenaline did not affect the distribution of glycogen synthase or glycogen phosphorylase which remained entirely bound to glycogen in these experiments. The specific release of protein phosphatase-1 from glycogen may facilitate its inactivation by inhibitor-1 in the cytosol, thereby preventing dephosphorylation of the glycogen metabolising enzymes. Translocation of protein phosphatase-1 may represent a novel mechanism for the activation of glycogenolysis and inhibition of glycogen synthesis by adrenaline.
The Extracellular Matrix of Blood Vessels (2009)

Blood vessels are highly organized and complex structure, which are far more than simple tubes conducting the blood to almost any tissue of the body. They are able to autonomously regulate the blood flow, thus providing the tissues an optimal support of oxygen and nutrients and an efficient removal of waste products. In higher organisms, the blood vessel forms a closed circuit system, which additionally has the ability to seal itself in case of leakage as a result of injury. The blood vessel system does not only transport soluble substances, but also serves as "highway" system for leukocytes to patrol the body during the immunological surveillance and to reach the inflammation site quickly. In a complex interplay with the vascular wall, leukocytes are able to penetrate the blood vessel without any obvious leakage. Pathologically, tumor cells subvert the blood vessel system to disseminate from the primary tumor and colonize distant organs during metastasis. The extracellular matrix (ECM) of a blood vessel contributes substantially to the diverse functions of the blood vessel. First, the ECM constitutes the scaffold which keeps the histological structure of the vessel wall in shape but also bears the enormous and permanent mechanical forces levied on the vessel by the pulsatile blood flow in the arteries and by vasoconstriction, which regulates blood flow and pressure. The complex network of elastic fibers and tensile forces-bearing networks are well adapted to accomplish these mechanical tasks. Second, the ECM provides informational cues to the vascular cells, thus regulating their proliferation and differentiation. Third, ECM molecules can store, mask, present or sequester growth factors, thereby modulating their effects remarkably. Furthermore, several ECM molecules serve additional functions within the blood vessel. Their expression is altered in a spatial and temporal pattern during blood vessel formation and remodeling. In contrast to vasculogenesis during embryonic development, blood vessel shows a remarkably and life-long plasticity, which allows the formation and regeneration of new blood vessel even in adulthood. Both physiologically during wound healing and pathologically during tumor growth, the sprouting of new blood vessels during angiogenesis is an important process, in which the ECM takes a key role.
Thyroid-stimulating hormone activates phospholipase C in normal and neoplastic thyroid tissue. (1993)

This is the first demonstration that TSH stimulates PLC activity in normal and neoplastic human thyroid tissue. Aberrant TSH-stimulated PLC activity was present in half of the aggressive thyroid neoplasms.
Adverse Events in Methotrexate-Treated Rheumatoid Arthritis Patients (1995)

Methotrexate (MTX) is an antifolate that has been in use for the treatment of rheumatoid arthritis (RA) since the early 1980s. Its efficacy has been clearly documented [1-4] and its administration early in the course of the disease is now generally accepted [5]. Side-effects from low weekly pulse MTX have been reported [1-6] and it was our initial experience that toxicity, rather than lack of efficacy, was the major factor limiting its clinical use [7]. However, when compared with other disease-modifying antirheumatic drugs, its toxicity appears to be comparable to that of antimalarials [8, 9]. The purpose of this paper is to discuss the possible mechanisms responsible for toxicity due to MTX used at low weekly pulse doses for the treatment of RA, as well as the different toxic manifestations reported in the literature.
Prognostic Significance of Occult Bone Marrow Micrometastases of Breast Cancer Detected by Quantitative Polymerase Chain Reaction for Cytokeratin 19 mRNA (2000)

Amplification of cytokeratin 19 (CK19) transcripts by reverse transcriptase-polymerase chain reaction (RT-PCR) has been shown to be a highly sensitive assay for the detection of bone marrow micrometastases (BMM) of breast cancer, but recent studies have demonstrated the occurrence of false-positive results due to low-level, illegitimately transcribed CK19 in normal bone marrow tissue. One approach to solve this problem is to develop a quantitative CK19 RT-PCR assay and to introduce a cut-off value which can distinguish between illegitimate expression and cancer-specific expression levels. In the present paper, we describe a quantitative CK19 RT-PCR assay using a real-time automated PCR system. The number of CK19 transcripts was normalized to that of GAPDH transcripts as an internal control for quality and quantity of cDNA. The cut-off value for the ratio of CK19 to GAPDH transcripts was set at 10(-4) since the ratio never exceeded this value in the control bone marrow samples (n = 12). In total, 117 bone marrow aspirates from stage I - III patients with invasive breast cancers were subjected to CK19 RT-PCR assay and immunocytological examination. Forty (34.2%) were found to be BMM-positive by CK19 RT-PCR assay whereas only three (2.6%) were found to be BMM-positive by immunocytology. Multivariate analysis has shown that occult BMM detected by CK19 RT-PCR is a significant risk factor for relapse, being independent of axillary lymph node metastases.
Downregulation of STAT3 activation is required for presumptive rod photoreceptor cells to differentiate in the postnatal retina (2005)

Ciliary neurotrophic factor (CNTF) has been known to inhibit the differentiation of presumptive rod photoreceptor cells; however, the underlying mechanisms have remained to be elucidated. We demonstrated that STAT3 activation, but not SHP2 activation, is responsible for the CNTF/gp130 signaling that inhibits expression of Rhodopsin and its upstream activator, crx, in the retinal explants derived from P0 mice (P0 retinal explants), utilizing STAT3-deficient retina and electroporation of dominant-negative form of STAT3 (STAT3F). We also demonstrated that STAT3 activation in presumptive rod photoreceptor cells at E18.5 is rapidly downregulated at P0, when Rhodopsin expression starts during retinal development. Persistent STAT3 activation in the P0 retinal explants prevented Rhodopsin expression and rapid upregulation of crx expression. STAT3-deficient retinas did not exhibit precocious Rhodopsin expression, although they exhibited precocious upregulation of crx mRNA. Thus, we conclude that downregulation of STAT3 activation is required, but insufficient, for rod photoreceptor cell differentiation in the postnatal retina.
Associating Microarray Data with a Survival Endpoint (2006)

In many microarray studies the primary objective is to identify, from a large panel of genes, those which are prognostic markers of a censored survival endpoint such as time to disease recurrence or death. These genes are considered prognostic in that their respective expressions are associated, in an appropriate sense, with the survival endpoint of interest. From a practical point of view, this requires not only specifying a appropriate measure of association and a suitable statistic thereof, but also, as the number of genes is large, proper handling of the consequential issue of multiplicity. In this paper, we will address the aforementioned issues by utilizing a general correlation measure and a non-parametric statistic, and by controlling the family-wise error rate by employing permutation resampling. Comprehensive simulation studies are conducted to investigate the statistical properties of the proposed procedure. The proposed procedure is demonstrated with microarray data.
ChemInform Abstract: Well‐Defined Air‐Stable Palladium HASPO Complexes for Efficient Kumada—Corriu Cross‐Couplings of (Hetero)Aryl or Alkenyl Tosylates. (2011)

Abstract The new palladium complexes (I) and (II) are used as highly efficient catalysts for the title process under mild conditions and at low loadings.
Coarse media filtration - an alternative to settling in wastewater treatment (2003)

In this paper coarse media filtration has been analysed as an alternative to the traditional settling in primary, secondary and tertiary treatment of wastewater. Various filter media configurations were evaluated for enhanced primary filtration. It was found that a dual media configuration based on Kaldnes biofilm media (1 and K2modified) were most suitable when taking both separation efficiency as well as filter run time into consideration. SS removal efficiencies of around 75% were achieved in the dual Kaldnes primary filter at around 20 m/h without any chemical addition and around 85% at low dosage (1-2 mg/l) of a high MW cationic polymer FO4440SH. In the latter case COD was removed by around 70%. Further experiments were carried out on a multi-media Kaldnes-Filtralite-Sand (KFS) filter for enhanced primary treatment as well as for secondary filtration directly downstream of a high-rate moving bed biofilm reactor, resulting in an extremely compact secondary treatment process. The secondary KFS-filter gave SS-removal efficiencies around 90% (effluent SS < 15 mg/l) and filter run times of around 24 hrs at filtration rates of 10 m/h (sludge loading rates of around 1 kg/m2h) when a small dose (2 mg/l) of polymer was used. It is also demonstrated that the primary filter may also be utilised as a pre-denitrification reactor. A denitrification rate of 1.5 kg NO3-N(equiv.)/m3d was achieved when the filter was operated at a filtration rate of 5 m/h.
Le manichéisme présentait-il en Afrique et à Rome des particularismes régionaux distinctifs? (1994)

En analysant des documents relatifs au manicheisme africain ou romain comme l'oeuvre augustinienne, les sermons du pape Leon le Grand, l'epitre de l'Auditeur romain Secundinus, l'A. trouve des nuances et des complementarites. Cependant, ces particularismes regionaux ne touchent en rien a la doctrine enseignee dans ces communautes manicheennes du monde occidental. Augustin et Faustus en furent les temoins. Les groupuscules qui tenterent de s'ecarter de la doctrine de Mani furent rejettes comme schismatiques. Cette religion du Livre demeura fondamentalement la meme
S-RNase Gene of Nicotiana alata Is Expressed in Developing Pollen (1993)

Peter N. Dodds, , He Du, , Marilyn A. Anderson, Ed Newbigin, Adrienne E. Clarke, S-RNase Gene of Nicotiana alata Is Expressed in Developing Pollen, The Plant Cell, Vol. 5, No. 12 (Dec., 1993), pp. 1771-1782
Synthesis of Nano-Sized SrTiO<sub>3</sub> Photocatalyst by Sol-Gel Method (2012)

A sol-gel processing technology was employed to synthesize fine SrTiO 3 powder by using strontium nitrate (Sr(NO 3 ) 2 ) , butyl titanate (Ti(OC 4 H 9 ) 4 ) as precursors, citric acid (C 6 H 8 O 6 ) as complexing agent and (ethylene) glycol (C 2 H 6 O 2 ) as stabilizer. Prepared the precursors in liquid phase and then calcined the precursors to achieve nano-sized SrTiO 3 powders. The microstructure and composition of the as-synthesized samples were characterized by X-ray diffraction (XRD), Scan Electron Microscopy (SEM), and the photocatalytic activity was studied. The results showed that all the SrTiO 3 particles were identified as perovskite phase. The pH values, the content of the acetic acid, the heat treat temperature play important roles on the synthesis of the SrTiO 3 photocatalyst. When the pH=1, n(Sr(NO 3 ) 2 ) : n(Ti(OC 4 H 9 ) 4 ) = 1 : 1, n(Sr(NO 3 ) 2 ) : n(C 6 H 8 O 6 )=1:1.7, the product has better rate of photodegradation for the Methylene Blue under the ultraviolet condition.
How to Define Biomarkers of Human T Cell Aging and Immunocompetence? (2013)

biomarkers will be of utmost importance to improve medical and preventive treatments in the elderly and to evaluate potential therapies that aim to rejuvenate the aged immune system.
Experimental separation of photoabsorption and Compton scattering contributions to He single and double ionization (1996)

We have experimentally separated the contributions of photoabsorption and Compton scattering to He single and double ionization for high‐energy photon impact by measuring the full momentum vector of the recoiling He1+,2+ ions. For recoil ions following photoabsorption large momenta and a distinct dipole emission pattern are observed. The ions produced by Compton scattering show small momenta. For the ratio of double to single ionization we find (1.22±.06)% at 8.8+1.5−1.65 keV for Compton scattering and (1.72±.12)% at 7.0+2.1−1.6 keV for photoabsorption. We compare our data with recent theories.
Dynamic Splinting in Children and Adolescents With Stiffness After Knee Surgery (2016)

Level IV-retrospective case series.
MIMO optical wireless at the nanoscale (2015)

In recent years, the rise of the field of optical nanoantennas has been largely impacting the way we control and engineer light-matter interactions at the nanoscale, translating and exploiting relevant antenna concepts from radiofrequencies to the optical domain. By efficiently coupling localized, or guided, optical fields to free-space radiation, and vice versa, optical nanoantennas find application in many different scenarios, e.g., sensing, photovoltaics, enhancement of weak non-linearities and quantum effects, local scattering control for wave-shaping metasurfaces, etc. Interestingly, pairs of plasmonic nanoantennas have also been proposed to realize optical wireless broadcasting links, which may allow sending nanoscale optical signals between two points on a chip, with lower attenuation than in conventional plasmonic waveguides (A. Alù and N. Engheta, Phys. Rev. Lett. 104, 213902, 2010). In a different context, it has been shown that subwavelength plasmonic nanostructures and nanoantennas can be designed to maximize the scattering/radiation contributions from several multipolar channels at the same time (dipolar radiation, quadrupolar, etc.), realizing “superscatterers” with, in principle, unbounded scattering cross section (Z. Ruan and S. Fan, Phys. Rev. Lett., 105, 013901, 2010). Here, by combining these concepts, we will show that it is possible to increase the capacity of optical wireless interconnects by using different multipolar radiation channels (i.e., orthogonal spherical harmonics) to simultaneously carry multiple optical signals (with identical frequency and polarization), effectively realizing a multiple-input multiple-output (MIMO) optical wireless link at the nanoscale.
Analyse et étude comparative des techniques et outils de mesure de la bande passante disponible (2005)

16 pages
Mobilization of Component Interface Stresses Between Soil and Pile Under Lateral Loading (2005)

The inelastic deformations for pile foundations under lateral loading occur below grade; therefore, the overall lateral load behavior of the system is influenced by the interaction between the shaft and the surrounding soil. This complex interaction is commonly modeled using p-y curves. The standard p-y method does not explicitly take into account all the key aspects of soil-pile interaction, namely the nonlinear response of the soil, frictional interface stresses between the soil and the pile, the generation of gaps between the soil and pile, damping under dynamic loads, and the structural response of the pile. Past research efforts have been aimed at developing unidirectional p-y interaction curves comprised of an assembly of distinct sub-elements; the sub-elements are each in charge of modeling a specific component of soil-pile resistance under lateral loading. These assembled soil-pile interaction curves are then compared to a backbone curve based on the existing standard p-y curves. However the current models for p-y curves are calibrated primarily from lateral load tests and lump all components of lateral resistance into one curve. Thus the contribution of each sub-element to the overall assembled behavior of the interaction "p-y" curve becomes somewhat arbitrary. This study examines the effects of nonlinear soil resistance to relative displacements between a model pile and soil, including the effects of gapping, cyclic degradation, and interfacial slip through laboratory testing. Measurements are presented for the normal compressive soil stress on the leading face of the pile, soil/pile interface stress along the sides of the pile, and active normal soil stresses on the pile. Using current sensor technology, normal stresses in soil are measured and side-frictional interface stresses are inferred. Professor Michael O'Neill stated in his Thirty-Fourth Karl Terzaghi Lecture that "the design of deep foundations is a complex matter that should be addressed in a design context by engineers who are experienced in the observation of pile behavior, theoretical modeling, and the appropriate use of design methods" — this paper attempts to stay true to Professor O'Neill's words by applying both observations from experimental measurements and theoretical modeling to a complex topic in foundation engineering.
Protein Purification with Polymeric Affinity Membranes Containing Functionalized Poly(acid) Brushes (2010)

Porous nylon membranes modified with poly(acid) brushes and their derivatives can rapidly purify proteins via ion-exchange and metal-ion affinity interactions. Membranes containing poly(2-(methacryloyloxy)ethyl succinate) (poly(MES)) brushes bind 118 +/- 8 mg of lysozyme per cm(3) of membrane and facilitate purification of lysozyme from chicken egg white. Moreover, functionalization of the poly(MES) brushes with nitrilotriacetate (NTA)-Ni(2+) complexes yields membranes that bind poly(histidine)-tagged (His-tagged) ubiquitin with a capacity of 85 +/- 2 mg of protein per cm(3) of membrane. Most importantly, the membranes modified with poly(MES)-NTA-Ni(2+) allow isolation of His-tagged cellular retinaldehyde-binding protein directly from a cell extract in <10 min, and the protein purity is comparable to that achieved with commercial affinity columns. Therefore, porous nylon membranes containing functionalized poly(MES) brushes are attractive candidates for rapid, high-capacity purification of His-tagged proteins from cell extracts.