gebhart/patrepeval huggingface dataset:
Figure S1. Notch-induced cell death in B-ALL. from Antileukemia Effects of Notch-Mediated Inhibition of Oncogenic PLK1 in B-Cell Acute Lymphoblastic Leukemia (2023)

&lt;p&gt;(A) Representative histograms of Annexin V abundance in Ph-like B-ALL patient samples cultured with pate-bound IgG-Fc and and increasing concentrations of DLL1-Fc after 3 days. (B) mRNA expression of Notch target gene HES1 in T-ALL and B-ALL cell lines and patient samples (Pt.B1, Pt.B2) was assessed by real-time qRT-PCR (in triplicate).&lt;/p&gt;
Interferon-inducible SAMHD1 restricts viral replication through downregulation of lipid synthesis (2022)

SAMHD1 plays an important role in IFN-mediated blockade of flaviviruses infection through targeting lipid bio-metabolic pathway.
Effect of additives: γ-Ray sensors based on ionizing organic nanocomposites (2019)

We have developed ionizing organic based composites which have demonstrated great promise for radiation sensing. Nickel oxide has been proven as an active material for detecting high energy radiation. The oxidation state of unusual oxides such as nickel oxide in nanocomposites of ionizing organics changes much faster than thin film or bulk, and hence increases the sensitivity for radiation sensing. The resistivity of the oxide composite increases following sequential irradiation processes because of the decrease in holes' concentration. In this paper, we will present the effect of additional oxidizing agent on the morphology, processing and sensing of γ-ray by oxides - urea based nanocomposites. It was observed that addition of MnO₂ decreases the sensitivity. However, it recovers to original properties after irradiation much faster than undoped composites.
Radiofrequency receiver based on compressive sampling for feature extraction in cognitive radio applications (2018)

Cette thèse traite de la conception de récepteurs radiofréquences basés sur l'acquisition compressée pour de l'estimation paramétrique en radio cognitive.L'acquisition compressée est un changement de paradigme dans la conversion analogique-numérique qui permet de s'affranchir de la fréquence d'échantillonnage de Nyquist.Dans ces travaux, les estimations sont effectuées directement sur les échantillons compressés vu le coût prohibitif de la reconstruction du signal d'entrée.Tout d'abord, l'aspect architecture du récepteur est abordé,avec notamment le choix des codes de mélange pour le convertisseur modulé à large bande (MWC).Une analyse haut niveau des propriétés de la matrice d'acquisition, à savoir la cohérence pour réduire le nombre de mesures et l'isométrie pour la robustesse au bruit,est menée puis validée par une plateforme de simulation.Enfin l'estimation paramétrique à partir des échantillons compressés est abordée à travers la borne de Cramér-Rao sur la variance d'un estimateur non biaisé.Une forme analytique de la matrice de Fisher est établie sous certaines hypothèses et permet de dissocier les effets de la compression et de la création de diversité.L'influence du processus d'acquisition compressée, notamment le couplage entre paramètres et la fuite spectrale, est illustré par l'exemple.
A Pseudo-Bayesian Algorithm for Robust PCA (2016)

Commonly used in many applications, robust PCA represents an algorithmic attempt to reduce the sensitivity of classical PCA to outliers. The basic idea is to learn a decomposition of some data matrix of interest into low rank and sparse components, the latter representing unwanted outliers. Although the resulting problem is typically NP-hard, convex relaxations provide a computationally-expedient alternative with theoretical support. However, in practical regimes performance guarantees break down and a variety of non-convex alternatives, including Bayesian-inspired models, have been proposed to boost estimation quality. Unfortunately though, without additional a priori knowledge none of these methods can significantly expand the critical operational range such that exact principal subspace recovery is possible. Into this mix we propose a novel pseudo-Bayesian algorithm that explicitly compensates for design weaknesses in many existing non-convex approaches leading to state-of-the-art performance with a sound analytical foundation.
Daniel H. Mintz (1930–2020): An Extraordinary Physician-Scientist and a Pioneer in Islet Transplantation (2021)

Daniel H. Mintz Fig. 1 was born in Far Rockaway, New York, in 1930 to European Jewish parents, Jacob and Fanny, and grew up on Long Island, New York, where his parents immigrated in the early 1900s. In his youth he excelled both in sports (basketball) and academically; he was accepted as a premed student at St. Bonaventure College, where he completed his Bachelor’s degree cum laude. He entered New York Medical College, which had no quotas for Jewish students (unlike many other schools at that time), and completed his medical training in 1956. (Fig. 2) While serving his internship at Henry Ford Hospital in Detroit, Michigan, he met his future wife, Dawn, a hospital nurse. In 1961, Dan entered residency at Georgetown University School of Medicine and joined the faculty, initiating his research career under the mentorship of Dr. Larry Kyle, Chairman of Medicine, studying parathyroid and bone disorders (1).



Daniel Mintz in 2006.





Daniel Mintz as a young student, and with his parents and sister at his medical graduation ceremony, New York Medical College, 1956.



Dan’s first love was clinical medicine, so it is no surprise that he was appointed Chief of Medicine at the then District of Columbia General Hospital in 1964. He once recounted the story that kept him in academic medicine after planning to start a private practice in Leesburg, Northern Virginia. Dr. Kyle called him into his office and told him in no uncertain terms that he was making a mistake and should remain in academia. As Dan recalled years later, “In those days you did what your boss told you to do!” This career-changing decision was a testament to Dan’s primary reason for entering medicine—to be a healer of the sick. His capacity for responding to people in need strongly influenced his …
Production Methods of D‐Mannitol (1985)

Abstract The present commercial production of D ‐mannitol, a valuable nutritive sweetener, takes place by hydrogenation of 1:1 D ‐glucose/ D ‐fructose mixtures over nickel. The low D ‐mannitol yield (25 — 30%), however, asks for the development of alternative procedures. A literature survey of the various production methods is given, including some other possible combinations of known procedures. It is concluded that the simultaneous use of glucose isomerase and copper‐on‐silica (combi‐process) is a promising procedure for the preparation of D ‐mannitol from D ‐glucose or D ‐glucose/ D ‐fructose syrups.
Development of an Experimental Device to Study Real Connecting-Rod Bearings Functioning in Severe Conditions (2007)

The paper presents a new experimental device made to analyze the thermoelastohydrodynamic (TEHD) behavior of connecting-rod bearings functioning in severe conditions. First, it focuses on the test bench description. The general principle of the test bench and then the main original technological solutions used with respect to the functional specifications are detailed. Two numerical models are described. They were developed in order to design and to validate two central components of the experimental device. Finally, the paper comments on the test results used to understand and validate the traction∕compression loading system, which is one of the key points in the test bench behavior.
Design of tunable magnetostatic volume wave filters with dispersion and bandwidth control (1991)

The possibility of controlling the bandwidth and the dispersion of a tunable magnetostatic volume wave (MSVW) delay line filter based on yttrium-iron-garnet (YIG) films is demonstrated. The simulation has been performed on a MSW filter consisting of two delay lines in cascade having opposite dispersion properties: a backward volume wave delay line and a forward volume wave one. The filter can be used effectively in the microwave frequency range for bandwidths between 20 MHz and 200 MHz, with the center frequency tunable with the DC magnetic bias.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A quantum dot fluorescent microsphere based immunochromatographic strip for detection of brucellosis (2021)

In our present study, the QDFM has promising application for on-site screening of brucellosis owing to its high detection speed, high sensitivity, high specificity and low cost.
InGaN/GaN multiple quantum well for fast scintillation application: radioluminescence and photoluminescence study (2014)

We prepare InGaN/GaN multiple quantum well (MQW) structure by metal-organic vapour phase epitaxy and characterize it by fine XRD measurements. We demonstrate its suitability for scintillator application including a unique measurement of wavelength-resolved scintillation response under nanosecond pulse soft x-ray source in extended dynamical and time scales. The photoluminescence and radioluminescence were measured: we have shown that the ratio of the intensity of quantum well (QW) exciton luminescence to the intensity of the yellow luminescence (YL) band IQW/IYL depends strongly on the type and intensity of excitation. Slower scintillation decay measured at YL band maximum confirmed the presence of several radiative recombination centres responsible for wide YL band, which also partially overlap with the QW peak. Further improvements of the structure are suggested, but even the presently reported decay characteristics of the excitonic emission in MQW are better compared to the currently widely used single crystal YAP:Ce or YAG:Ce scintillators. Thus, such a type of a semiconductor scintillator is highly promising for fast detection of soft x-ray and related beam diagnostics.
Increased Prevalence of Metabolic Syndrome and Adipocytokine Levels in a Psoriatic Arthritis Cohort (2018)

The prevalence of MetS was higher in PsA patients compared with non-PsA control subjects in this Mediterranean population. Clinicians caring for PsA patients ought to be aware of the increased risk of MetS in PsA patients, confirmed in different regions worldwide. The increased MetS seems to be linked to central obesity in these patients, and appropriate treatment recommendations are advised.
Human Monoclonal Autoantibodies to B-Cell Epitopes Outside the Thyroid Peroxidase Autoantibody Immunodominant Region (2001)

Human autoantibodies to thyroid peroxidase (TPO) interact with a restricted or immunodominant region (IDR) on intact TPO. However, a smaller proportion of polyclonal serum TPO autoantibodies bind outside this region. To isolate monoclonal nonimmunodominant region (non-IDR) TPO autoantibodies, we screened a thyroid-derived immunoglobulin gene phage display library while "epitope masking" the TPO IDR with four human TPO monoclonal autoantibodies that define the IDR. Among 31 non-IDR autoantibodies obtained (expressed as Fab), 8 representatives were analyzed further based on their restriction digestion profiles. All are encoded by almost identical H chains (VH3 family), with extremely long D regions, paired with three different types of light chains. In contrast, IDR TPO Fab from the same patient utilize seven different heavy chains (VH1 and VH5 families) paired nonpromiscuously with different light chains. Use of VH5 genes has not been reported previously for TPO autoantibodies. Both non-IDR and IDR Fab bind specifically to TPO and not to other proteins. The non-IDR Fab affinities for TPO are moderately high (Kd 1-2 x 10(-9) M), somewhat lower than those for most IDR Fab (Kd 1-4 x 10(-10) M). The epitopes of the three types of non-IDR Fab overlap with each other, indicating a major role for their heavy chain in TPO binding. Most importantly, the epitopes of non-IDR Fab are recognized by patients' serum autoantibodies. In summary, we provide the first insight into the immunoglobulin genes, affinities and epitopes of human monoclonal autoantibodies that bind outside the TPO-immunodominant region.
Photopolymerization Parameters Influence Mechanical, Microstructural, and Cell Loading Properties of Rapidly Fabricated Cell Scaffolds (2023)

Engineered scaffolds are commonly used to assist in cellular transplantations, providing crucial support and specific architecture for a variety of tissue engineering applications. Photopolymerization as a fabrication technique for cell scaffolds enables precise spatial and temporal control of properties and structure. One simple technique to achieve a two-dimensional structure is the use of a patterned photomask, which results in regionally selective photo-cross-linking. However, the relationships between photopolymerization parameters like light intensity and exposure time and outcomes like structural fidelity and mechanical properties are not well-established. In this work, we used photopolymerization to generate degradable polycaprolactone triacrylate (PCLTA) scaffolds with a defined microstructure. We examined the impact of light intensity and exposure time on scaffold properties such as shear modulus and micropore structure. To assess feasibility in a specific application and determine the relationship between parameter-driven properties and cell loading, we cultured retinal progenitor cells on the PCLTA scaffolds. We found that light intensity and polymerization time directly impact the scaffold stiffness and micropore structure, which in turn influenced the cell loading capacity of the scaffold. Because material stiffness and topography are known to impact cell viability and fate, understanding the effect of scaffold fabrication parameters on mechanical and structural properties is critical to optimizing cell scaffolds for specific applications.
Humans Predict Action using Grammar-like Structures (2020)

Efficient action prediction is of central importance for the fluent workflow between humans and equally so for human-robot interaction. To achieve prediction, actions can be algorithmically encoded by a series of events, where every event corresponds to a change in a (static or dynamic) relation between some of the objects in the scene. These structures are similar to a context-free grammar and, importantly, within this framework the actual objects are irrelevant for prediction, only their relational changes matter. Manipulation actions and others can be uniquely encoded this way. Using a virtual reality setup and testing several different manipulation actions, here we show that humans predict actions in an event-based manner following the sequence of relational changes. Testing this with chained actions, we measure the percentage predictive temporal gain for humans and compare it to action-chains performed by robots showing that the gain is approximately equal. Event-based and, thus, object independent action recognition and prediction may be important for cognitively deducing properties of unknown objects seen in action, helping to address bootstrapping of object knowledge especially in infants.
Life, death, and Catholic medical choices: 50 questions from the pews (2011)

In Life, Death, and Medical Choices: 50 Questions from the Pews, Revs. Black and O'Neil bring professional training in Catholic ethics into dialogue with questions that people in the pews must face. Using precise language they help us understand the core values of respect for life and human dignity that are the heart of moral analysis and pastoral theological reflection.[From publisher's website] ISBN: 9780764819537
Individers agerande vid investerings- och avyttringsbeslut i aktier - en analys av regret theorys giltighet (2002)

Resultaten av vår undersökning visar på att vi generellt sett inte kan säga om individuella investerare agerar enligt regret theory eller inte. En del resultat tyder dock på att vissa effekter inom teorin är applicerbar på individuella investerare. Vi kan urskilja trender som tyder på att individen beter sig på ett visst sett och resonerat kring varför han beter sig så. Individen föredrar alltid det säkra alternativet om förluster eller stora vinster står på spel. Om skillnaden i säkerhet är väldigt liten försummar han den. Om det är en väldigt liten förtjänst som står på spel föredrar indivien osäkerhet, och likaså om skillnaden i säkerhet är relativt liten.
Fabrication and Characterization of Lead Sulfide Thin Films by Atomic Layer Deposition (2008)

We present a study of the deposition of lead sulfide (PbS) thin films by atomic layer deposition (ALD). PbS films were deposited from Pb(tmhd)2 and H2S precursors at precursor sublimation temperatures of 165-175 C. The film growth rate was 1.3-1.8 Aå/cycle, which is higher than previously published values. A linear growth rate characteristic of ALD was observed, with no chemical contamination. Film properties are studied using XPS, XRD, SEM and AFM measurements. AFM images show that the films are polycrystalline with grain size increasing with film thickness. Calculations have been performed using Density Functional Theory (DFT) to model the reaction mechanism.
ChemInform Abstract: SYNTHESIS APPLICATIONS OF DIRECTED 2‐AZONIA‐(3,3)‐SIGMATROPIC REARRANGEMENTS. 4. A NEW METHOD FOR STEREOSELECTIVE PIPERIDINE ANNULATION. DIRECTING THE 2‐AZONIA‐(3,3)‐SIGMATROPIC REARRANGEMENT BY IRREVERSIBLE HYDROLYSIS (1981)

Abstract Aus dem Amin (I) entstehen bei der Behandlung mit Benzaldehyd und Allylmagnesiumbromid die beiden substituierten Verbindungen (II) und (IIIa).
Comparison of reconstruction algorithms for digital breast tomosynthesis (2009)

Digital breast tomosynthesis (DBT) is an emerging modality for breast imaging. A typical tomosynthesis image is reconstructed from projection data acquired at a limited number of views over a limited angular range. In general, the quantitative accuracy of the image can be significantly compromised by severe artifacts and non-isotropic resolution resulting from the incomplete data. Nevertheless, it has been demonstrated that DBT may yield useful information for detection/classification tasks and thus is considered a promising breast imaging modality currently undergoing pre-clinical evaluation trials. The purpose of this work is to conduct a preliminary, but systematic, investigation and evaluation of the properties of reconstruction algorithms that have been proposed for DBT. We use a breast phantom designed for DBT evaluation to generate analytic projection data for a typical DBT configuration, which is currently undergoing pre-clinical evaluation. The reconstruction algorithms under comparison include (i) filtered backprojection (FBP), (ii) expectation maximization (EM), and (iii) TV-minimization algorithms. Results of our studies indicate that FBP reconstructed images are generally noisier and demonstrate lower in-depth resolution than those obtained through iterative reconstruction and that the TV-minimization reconstruction yield images with reduced artifacts as compared to that obtained with other algorithms under study.
Modern applications of ureteroscopy for intrarenal stone disease (2010)

The indications for ureteroscopic management of renal calculi are expanding, and this technique is quickly being adopted as a routine option for the management of intrarenal stone disease.
Electrochromic Window Based on Conducting Poly(3,4-ethylenedioxythiophene)-Poly(styrene sulfonate) (2002)

A short survey of technological aspects of electrochromism with various electroactive species is given. Different approaches with inorganic and organic materials have been pursued in the past. So far widespread usage of this technology for large area applications has not been achieved. Nevertheless one major technical product, self-darkening rear-view mirrors for cars, is already well established. This article reviews some research results on electroactive polythiophenes, especially poly(3,4-alkylenedioxythiophenes). Some promising results with the commercially available electrically conducting polymer Baytron P (PEDT/PSS) are presented. It is demonstrated that an all solid-state electrochromic multilayer assembly based on a polymeric electrochromic material might be close to technical realization. The coating of large area substrates with aqueous poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) dispersion can be a way to an economically viable product.
Uncertainty analysis in the measurement of the spatial responsivity of infrared antennas (2005)

The measurement of a two-dimensional spatial responsivity map of infrared antennas can be accomplished by use of an iterative deconvolution algorithm. The inputs of this algorithm are the spatial distribution of the laser beam irradiance illuminating the antenna-coupled detector and a map of the measured detector response as it moves through the illuminating beam. The beam irradiance distribution is obtained from knife-edge measurements of the beam waist region; this data set is fitted to a model of the beam. The uncertainties, errors, and artifacts of the measurement procedure are analyzed by principal-component analysis. This study has made it possible to refine the measurement protocol and to identify, classify, and filter undesirable sources of noise. The iterative deconvolution algorithm stops when a well-defined threshold is reached. Spatial maps of mean values and uncertainties have been obtained for the beam irradiance distribution, the scanned spatial response data, and the resultant spatial responsivity of the infrared antenna. Signal-to-noise ratios have been defined and compared, and the beam irradiance distribution characterization has been identified as the statistically weakest part of the measurement procedure.
Neurologic Complications of Pediatric Femoral Nailing (1996)

Summary Neurologic complications of femoral rodding with interlocking nails were investigated in 35 consecutive pediatric patients, aged 10-17 years, with traumatic femur fractures. We examined various risk factors for neurologic complications, including timing and duration of surgery, preoperative and intraoperative traction type, adequacy of preoperative traction, intraoperative patient position, degree of communution of the fracture, and use of interlocking screws. There were eight (22.2%) neurologic complications. Of these, only two (5.6%) persisted for longer than a week. The combination of surgical delay >48 h, preoperative shortening, and the use of boot traction increased the incidence of all palsies to 5.68 times and peroneal palsies to 11.4 times that of patients without this combination of risk factors. Adequate pre- and intraoperative skeletal traction, especially in patients with hours of surgical delay, may decrease the incidence of neurologic complications in pediatric femoral nailings.
Recent advances on state estimation for power grids with unconventional measurements (2017)

State estimation problem for power systems has long been a fundamental issue that demands a variety of methodologies depending on the system settings. With the recent introduction of advanced devices of phasor measurement units (PMUs) and dedicated communication networks, the infrastructure of power grids has been greatly improved. Coupled with the infrastructure improvements are three emerging issues for the state estimation problems, namely, the coexistence of both traditional and PMU measurements, the incomplete information resulting from delayed, asynchronous and missing measurements due to communication constraints, and the cyber‐attacks on the communication channels. In this study, the authors aim to survey some recent advances on the state estimation methods which tackle the above three issues in power grids. Traditional state estimation methods applied in power grids are first introduced. Latest results on state estimation with mixed measurements and incomplete measurements are then discussed in great detail. In addition, the techniques developed to ensure the cyber‐security of the state estimation schemes for power grids are highlighted. Finally, some concluding remarks are given and some possible future research directions are pointed out.