gebhart/patrepeval huggingface dataset:
Analysis of RC interconnections under ramp input (1996)

Article Analysis of RC interconnections under ramp input Share on Authors: Andrew B. Kahng UCLA Computer Science Department, Los Angeles, CA UCLA Computer Science Department, Los Angeles, CAView Profile , Sudhakar Muddu UCLA Computer Science Department, Los Angeles, CA UCLA Computer Science Department, Los Angeles, CAView Profile Authors Info & Claims DAC '96: Proceedings of the 33rd annual Design Automation ConferenceJune 1996 Pages 533–538https://doi.org/10.1145/240518.240619Online:01 June 1996Publication History 6citation214DownloadsMetricsTotal Citations6Total Downloads214Last 12 Months0Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Membrane orientation of droplets from Chara corallina internodal cells (2001)

It is generally accepted that the membrane surrounding droplets from characean cells originates from the tonoplast, but there is some uncertainty regarding droplet membrane sidedness. This issue was addressed directly by combining two different droplet isolation methods and the patch clamp technique. Neutral red accumulation was used to demonstrate the presence of H+-transport over the membrane and to predict membrane orientation. Two types of droplet populations with differently oriented membranes could be formed in an iso-osmotic bath solution Cytoplasmic droplets (cytosolic side of the tonoplast inside) contained cytoplasm, while the second type of droplet population contained vacuolar sap (vacuolar droplets, vacuolar side of the tonoplast inside). Smaller vesicles also appeared inside the droplets, with an apparently inversely oriented membrane. Confocal laser scanning microscopy indirectly demonstrated that, at least with one of the droplet isolation methods, the plasma membrane entirely remains in the internodal cell after intracellular perfusion. Both types of droplet populations allowed the formation of excised patches and single-channel measurements by the patch clamp technique. Properties of anion channels in the tonoplast could be used to prove the predicted membrane orientation, knowing that Ca2+ can only activate these channels from the cytosolic side. These results provide useful data for studies addressing ligand-binding, block and modulation, organization and interaction of proteins within the membrane or with other regulatory factors, where it is important to control membrane orientation.
Mapping Partially Observable Features from Multiple Uncertain Vantage Points (2002)

In this paper we present a technique for mapping partially observable features from multiple uncertain vantage points. The problem of concurrent mapping and localization (CML) is stated as follows. Starting from an initial known position, a mobile robot travels through a sequence of positions, obtaining a set of sensor measurements at each position. The goal is to process the sensor data to produce an estimate of the trajectory of the robot while concurrently building a map of the environment. In this paper, we describe a generalized framework for CML that incorporates temporal as well as spatial correlations. The representation is expanded to incorporate past vehicle positions in the state vector. Estimates of the correlations between current and previous vehicle states are explicitly maintained. This enables the consistent initialization of map features using data from multiple time steps. Updates to the map and the vehicle trajectory can also be performed in batches of data acquired from multiple vantage points. The method is illustrated with sonar data from a testing tank and via experiments with a B21 land mobile robot, demonstrating the ability to perform CML with sparse and ambiguous data.
Review: Multiscale Thermal Modeling in Nanoelectronics (2005)

Subcontinuum phonon conduction phenomena impede the cooling of field-effect transistors with gate lengths less than 100 nm, which degrades their performance and reliability. Thermal modeling of these nanodevices requires attention to a broad range of length scales and physical phenomena, ranging from continuum heat diffusion to atomic-scale interactions and phonon confinement. This review describes the state of the art in subcontinuum thermal modeling. Although the focus is on the silicon field-effect transistor, the models are general enough to apply to other semiconductor devices as well. Special attention is given to the recent advances in applying statistical and atomistic simulation methods to thermal transport.
Image quality improvement in cone-beam CT using deep learning (2019)

We propose a learning method to generate corrected CBCT (CCBCT) images with the goal of improving the image quality and clinical utility of on-board CBCT. The proposed method integrated a residual block concept into a cyclegenerative adversarial network (cycle-GAN) framework, which is named as Res-cycle GAN in this study. Compared with a GAN, a cycle-GAN includes an inverse transformation from CBCT to CT images, which could further constrain the learning model. A fully convolution neural network (FCN) with residual block is used in generator to enable end-toend transformation. A FCN is used in discriminator to discriminate from planning CT (ground truth) and correction CBCT (CCBCT) generated by the generator. This proposed algorithm was evaluated using 12 sets of patient data with CBCT and CT images. The mean absolute error (MAE), peak signal-to-noise ratio (PSNR), normalized cross correlation (NCC) indexes and spatial non-uniformity (SNU) in the selected regions of interests (ROIs) were used to quantify the correction accuracy of the proposed algorithm. Overall, the MAE, PSNR, NCC and SNU were 20.8±3.4 HU, 32. 8±1.5 dB, 0.986±0.004 and 1.7±3.6%. We have developed a novel deep learning-based method to generate CCBCT with a high image quality. The proposed method increases on-board CBCT image quality, making it comparable to that of the planning CT. With further evaluation and clinical implementation, this method could lead to quantitative adaptive radiotherapy.
Anthony Edward Howarth (2013)

Anthony Edward Howarth (“Tony”) was a gifted ear, nose, and throat surgeon, like his father before him. He was a highly esteemed clinician, colleague, and mentor, who remembered all the names of his young patients and championed the idea of parents seeing their children in hospital at a time …
Delay defect screening for a 2.16GHz SPARC64 microprocessor (2006)

This paper presents a case-study of delay defect screening applied to Fujitsu 2.16GHz SPARC64 microprocessor. A non-robust delay test is used while each test vector is compacted to detect multiple transition faults in a standard scan-based design targeting a stuck-at fault test. Our test technique applied to a microprocessor designed with 6M gate logic, 4MB level 2 cache, and 239K latches, achieves 90% coverage using 3,103 test vectors. We estimate the distribution of the delay of paths covered by our delay test. We also show the effectiveness of our method by discussing the correlation between the screening result and the actual number of delay defects.
Modification of polysaccharides from callus culture of Silene vulgaris (M.) G. using carbohydrases in vitro (2007)

Polysaccharides (pectin and intracellular and extracellular arabinogalactans) were isolated from campion callus culture cultivated on medium with varied concentrations of pectinase and beta-galactosidase. A decrease in contents of arabinose residues in pectin and arabinogalactans and of galactose residues in arabinogalactans was associated with an increase in the activities of alpha-L-arabinofuranosidase and beta-galactosidase upon addition of pectinase into the medium. Pectinase destroyed the high-molecular-weight (more than 300 kD) fraction of pectin and decreased the content of galacturonic acid residues. alpha-L-Arabinofuranosidase transformed arabinogalactan into galactan, and galactan was destroyed under the influence of galactosidase. The contents of arabinogalactan and/or galactan in the cells were decreased, and it was released into the culture medium. Pectin samples with low contents of arabinose and galactose in the side chains and galactan samples were obtained from the callus grown on the medium with beta-galactosidase. Cultivation of the plant cells on medium containing carbohydrases resulted in modification of pectin and arabinogalactan of the cell walls.
MP-Trees: A Packing-Based Macro Placement Algorithm for Modern Mixed-Size Designs (2008)

In this paper, we present a new multipacking-tree (MP-tree) representation for macro placements to handle modern mixed-size designs with large macros and high chip utilization rates. Based on binary trees, the MP-tree is very efficient, effective, and flexible for handling macro placements with various constraints. Given a global placement that already considers the areas and the interconnections among standard cells and macros, our MP-tree-based macro placer optimizes macro positions, minimizes the macro displacement from the initial macro positions, and maximizes the area of the chip center for standard-cell placement and routing. Experiments based on the Proceedings of the 2006 International Symposium on Physical Design placement contest benchmarks and Faraday benchmarks show that our macro placer combined with APlace 2.0, Capo 10.2, mPL6, or NTUplace3 for a standard-cell placement outperforms these state-of-the-art academic mixed-size placers alone by large margins in robustness and quality. In addition to wirelength, experiments on four real industrial designs with large macros and high utilization rates show that our method significantly reduces the average half-perimeter wirelength by 35 %, the average routed wirelength by 55 %, and the routing overflows by 13 times compared with Capo 10.2, implying that our macro placer leads to much higher routability.
Self‐Metathesis of Polyol Allyl Ethers towards Carbohydrate‐Based Oligohydroxy Derivatives (2012)

Abstract Various allyl ethers of 1,4‐anhydro‐ D ‐sorbitol and pentaerythritol were synthesised as starting materials for self‐metathesis reactions. Thus, dimeric compounds having six free hydroxy groups became accessible and should be used as potential analogues of dipentaerythritol for alkyd resin formation.
Reactivity of Two Selected Antigens of Neisseria gonorrhoeae (1969)

Two antigen preparations, the soluble antigen and a fraction 1 thereof, isolated in the course of a systematic study of the various antigens of the virulent gonococcus, have been investigated for their ability to serve as antigens for the detection of antibody in patients infected with the gonococcus. The soluble antigen was reactive with 88.2% of the sera from infected females, and fraction 1 was reactive with 71.6% of the sera. Of sera from infected males, only 27.6% reacted with the soluble antigen and only 20.4% with fraction 1. Of sera from individuals presumed free of gonococcal infection, approximately 4% reacted with the soluble antigen; none reacted with fraction 1. This study suggests that these antigens might be adaptable to the detection of human gonococcal antibody, especially in the female.
Isolation of cDNA encoding the human NF-E2 protein. (1993)

The human homolog of mouse NF-E2 was isolated from the K562 cell line and found to encode a member of the basic leucine-zipper family of DNA-binding regulatory proteins. The deduced amino acid sequence of the mouse and human proteins exhibited near identity. Comparison to the related protein, Nrf1, revealed significant homologies at isolated regions, particularly within the basic domain, suggesting that NF-E2 and Nrf1 are members of a distinct subfamily of basic leucine-zipper proteins that share similar DNA-binding properties. High levels of human NF-E2 mRNA were observed in human erythroleukemic cell lines examined. Extensive survey of human tissue samples found NF-E2 expression not limited to erythropoeitic organs. Expression in the colon and testis suggests that NF-E2 may participate in the regulation of genes other than globin.
Metal-free synthesis of polysubstituted pyrroles using surfactants in aqueous medium (2017)

An efficient and metal-free method has been developed for the synthesis of polysubstituted pyrrole derivatives with combination of sodium dodecyl sulphate (SDS) and Triton X-100 surfactants using water as a solvent at room temperature in 2–6 h and under microwave conditions (10 min) with good to excellent yields.
Frequency-Tunable THz Source Based on Stimulated Polariton Scattering in ${\rm Mg{:}LiNbO}_{3}$ (2013)

We report a very compact, laser diode end-pumped THz laser source, which utilizes two resonators to generate frequency-tunable radiation across the range 1.53-2.82 THz via stimulated polariton scattering (SPS) in a Mg:LiNbO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> crystal. To the best of our knowledge, this THz system operates with the lowest pump power threshold (2.4 W), and highest conversion efficiency (6.45ţW average output power at 1.82 THz for 5 W input diode pump power) ever reported for a THz source based on SPS.
Parallel analysis of ribonucleotide-dependent deletions produced by yeast Top1in vitroandin vivo (2016)

Ribonucleotides are the most abundant non-canonical component of yeast genomic DNA and their persistence is associated with a distinctive mutation signature characterized by deletion of a single repeat unit from a short tandem repeat. These deletion events are dependent on DNA topoisomerase I (Top1) and are initiated by Top1 incision at the relevant ribonucleotide 3'-phosphodiester. A requirement for the re-ligation activity of Top1 led us to propose a sequential cleavage model for Top1-dependent mutagenesis at ribonucleotides. Here, we test key features of this model via parallel in vitro and in vivo analyses. We find that the distance between two Top1 cleavage sites determines the deletion size and that this distance is inversely related to the deletion frequency. Following the creation of a gap by two Top1 cleavage events, the tandem repeat provides complementarity that promotes realignment to a nick and subsequent Top1-mediated ligation. Complementarity downstream of the gap promotes deletion formation more effectively than does complementarity upstream of the gap, consistent with constraints to realignment of the strand to which Top1 is covalently bound. Our data fortify sequential Top1 cleavage as the mechanism for ribonucleotide-dependent deletions and provide new insight into the component steps of this process.
Probabilistic Planning with Reduced Models (2019)

Reduced models are simplified versions of a given domain, designed to accelerate the planning process. Interest in reduced models has grown since the surprising success of determinization in the first international probabilistic planning competition, leading to the development of several enhanced determinization techniques. To address the drawbacks of previous determinization methods, we introduce a family of reduced models in which probabilistic outcomes are classified as one of two types: primary and exceptional. In each model that belongs to this family of reductions, primary outcomes can occur an unbounded number of times per trajectory, while exceptions can occur at most a finite number of times, specified by a parameter. Distinct reduced models are characterized by two parameters: the maximum number of primary outcomes per action, and the maximum number of occurrences of exceptions per trajectory. This family of reductions generalizes the well-known most-likely-outcome determinization approach, which includes one primary outcome per action and zero exceptional outcomes per plan. We present a framework to determine the benefits of planning with reduced models, and develop a continual planning approach that handles situations where the number of exceptions exceeds the specified bound during plan execution. Using this framework, we compare the performance of various reduced models and consider the challenge of generating good ones automatically. We show that each one of the dimensions---allowing more than one primary outcome or planning for some limited number of exceptions---could improve performance relative to standard determinization. The results place previous work on determinization in a broader context and lay the foundation for a systematic exploration of the space of model reductions.
Identification of a neutralizing epitope within minor repeat region of Plasmodium falciparum CS protein (2021)

Malaria remains a major cause of morbidity and mortality worldwide with 219 million infections and 435,000 deaths predominantly in Africa. The infective Plasmodium sporozoite is the target of a potent humoral immune response that can protect murine, simian and human hosts against challenge by malaria-infected mosquitoes. Early murine studies demonstrated that sporozoites or subunit vaccines based on the sporozoite major surface antigen, the circumsporozoite (CS) protein, elicit antibodies that primarily target the central repeat region of the CS protein. In the current murine studies, using monoclonal antibodies and polyclonal sera obtained following immunization with P. falciparum sporozoites or synthetic repeat peptides, we demonstrate differences in the ability of these antibodies to recognize the major and minor repeats contained in the central repeat region. The biological relevance of these differences in fine specificity was explored using a transgenic P. berghei rodent parasite expressing the P. falciparum CS repeat region. In these in vitro and in vivo studies, we demonstrate that the minor repeat region, comprised of three copies of alternating NANP and NVDP tetramer repeats, contains an epitope recognized by sporozoite-neutralizing antibodies. In contrast, murine monoclonal antibodies specific for the major CS repeats (NANP)<sub>n</sub> could be isolated from peptide-immunized mice that had limited or no sporozoite-neutralizing activity. These studies highlight the importance of assessing the fine specificity and functions of antirepeat antibodies elicited by P. falciparum CS-based vaccines and suggest that the design of immunogens to increase antibody responses to minor CS repeats may enhance vaccine efficacy.
Optimized Robust Adaptive Estimation of Flux and Torque in Electric Drive (1992)

Abstract This paper presents an optimized robust adaptive flux and torque estimator for torque vector controlled reluctance motor drive. Unlike the existing techniques which are effective only in steady-state, the estimator developed here can work property during transient and steady-stale, for quickly, slowly, or constantly varying machine parameters. The effectiveness of this flux and torque estimator stems from the idea of reducing the uncertainties of the machine parameter to increase the estimation accuracy because parameter detunings are the main causes for the estimation fault. Detailed estimation error analysis are studied to investigate the nature of the problem. Based on those analysis, the estimation algorithm is robustized and optimized. Extensive digital simulation results show excellent performance of this estimator for both transient and steady-state conditions.
MYC-related microRNAs signatures in non-Hodgkin B-cell lymphomas and their relationships with core cellular pathways (2018)

In order to investigate the role of microRNAs in the pathogenesis of different B-cell lymhoma subtypes, we have applied an array-based assay to a series of 76 mixed non-Hodgkin B-cell lymphomas, including Burkitt's lymphoma (BL), diffuse large B-cell lymphoma, primary mediastinal B-cell lymphoma, mantle cell lymphoma (MCL) and follicular lymphoma. Lymphomas clustered according to histological subtypes, driven by two miRNA clusters (the miR-29 family and the miR-17-92 cluster). Since the two miRNA clusters are known to be MYC-regulated, we investigated whether this would be supported in MYC-driven experimental models, and found that this signature separated BL cell lines and a <i>MYC</i>-translocated MCL cell lines from normal germinal center B-cells and other B-cell populations. Similar results were also reproduced in tissue samples comparing BL and reactive lymph node samples. The same series was then quantitatively analyzed for MYC expression by immunohistochemistry and MYC protein levels were compared with corresponding miRNA signatures. A specific metric was developed to summarize the levels of MYC-related microRNAs and the corresponding protein levels. We found that MYC-related signatures are directly related to MYC protein expression across the whole spectrum of B-cells and B-cell lymphoma, suggesting that the MYC-responsive machinery shows predominantly quantitative, rather than qualitative, modifications in B-cell lymphoma. Novel MYC-related miRNAs were also discovered by this approach. Finally, network analysis found that in BL MYC-related differentially expressed miRNAs could control, either positively or negatively, a limited number of hub proteins, including BCL2, CDK6, MYB, ZEB1, CTNNB1, BAX and XBP1.
Critical steps in the anodic bonding process for fabrication of CMUTs (2012)

International audience
In vitro studies on periodontal ligament cells and enamel matrix derivative (1997)

The recognition that periodontal regeneration can be achieved has resulted in increased efforts focused on understanding the mechanisms and factors required for restoring periodontal tissues so that clinical outcomes of such therapies are more predictable than those currently being used. In vitro models provide an excellent procedure for providing clues as to the mechanisms that may be required for regeneration of tissues. The investigations here were targeted at determining the ability of enamel matrix derivative (EMD) to influence specific properties of periodontal ligament cells in vitro. Properties of cells examined included migration, attachment, proliferation, biosynthetic activity and mineral nodule formation. Immunoassays were done to determine whether or not EMD retained known polypeptide factors. Results demonstrated that EMD under in vitro conditions formed protein aggregates, thereby providing a unique environment for cell-matrix interaction. Under these conditions, EMD: (a) enhanced proliferation of PDL cells, but not of epithelial cells; (b) increased total protein production by PDL cells; (c) promoted mineral nodule formation of PDL cells, as assayed by von Kossa staining; (d) had no significant effect on migration or attachment and spreading of cells within the limits of the assay systems used here. Next, EMD was screened for possible presence of specific molecules including: GM-CSF, calbindin D, EGF, fibronectin, bFGF, gamma-interferon, IL-1 beta, 2, 3, 6; IGF-1,2; NGF, PDGF, TNF, TGF beta. With immunoassays used, none of these molecules were identified in EMD. These in vitro studies support the concept that EMD can act as a positive matrix for cells at a regenerative site.