gebhart/patrepeval huggingface dataset:
Similar effects of nifedipine and hydralazine on anaesthesia and hypermotility induced by pentobarbitone in mice (1992)

Nifedipine, a dihydropyridine calcium channel blocker, and hydralazine, a non-calcium channel antagonist vasodilatator, enhanced pentobarbitone-induced sleeping time and reversed locomotor hyperactivity induced by a subhypnotic dose of the barbiturate in mice. The similarity of the behavioural effects, exerted by nifedipine and hydralazine, suggest that haemodynamic factors may play an important role in the interaction of calcium channel antagonists with barbiturates.
Evaluation and Manufacturing of Unidirectional CF/PA6 rod using Pultrusion Molding (2019)

Carbon fiber reinforced thermoplastic (CFRTP) rivet is needed for multi-material to achieve weight reduction and high strength. For manufacturing rivet made of CFRTP, it is necessary to mold CFRTP rod. To mold CFRTP rod, pultrusion molding which has extremely productive and environmental performance is the most suitable method in CFRTP molding methods. The process of pultrusion molding melts materials by heating and solidify it by cooling. Because of its continuous molding method, pultrusion process is semi-permanently molding method as long as supplying the materials. The material used in pultrusion molding is a unidirectional opening carbon fiber polyamide 6 semi prepreg sheet.(Opening UD-CF/PA6 semi prepreg sheet). But It hasn’t been known that the input amount of Opening UD-CF/PA6 semi prepreg sheet affects mechanical characteristics and volume fraction of fiber of CFRTP rods. This study aims to develop the unidirectional CFRTP rods using pultrusion method and investigate effects of the input amount of the materials. The experiments results revealed that increasing of input amount of materials improve the mechanical characteristics and volume fraction of fiber. The highest number of fiber volume fraction, maximum bending strength and bend elastic constant of molded CFRTP rod in this study is 48 vol%, 284 MPa and 36 GPa.
The role of exposome in acne: results from an international patient survey (2019)

Data from this international, anonymized Internet questionnaire conducted with more than almost 6700 participants add new arguments to assumptions made that certain exposome factors have an impact on acne. Nutrition, pollution, stress and harsh skincare, as well as climate and sun exposure may be considered the most frequent factors related to acne.
Primary hyperparathyroidism: pathophysiology, diagnosis and indications for surgery. (2001)

There is little debate about the primacy of surgery in the management of symptomatic or complicated primary hyperparathyroidism. Rather, the question has been what to do about the many patients with nonclassical disease. Recent prospective data have confirmed that patients with asymptomatic primary hyperparathyroidism who are not surgical candidates for parathyroidectomy appear to do well when they are managed conservatively. On average, these patients remain stable, with little progression to the more serious manifestations of hyperparathyroidism over 10 years. It would seem, therefore, that the overall population of older patients with mild asymptomatic primary hyperparathyroidism can be safely followed without intervention. A certain proportion of cases do progress, however, so surveillance is necessary. Individual patients can have worsening hypercalcemia or hypercalciuria, and in a small percentage of patients, bone density may decrease over time. In most patients, deferral of surgery is not a one-time decision, but rather one that is reviewed and reconsidered in conjunction with meticulous monitoring.
Phase 2 of the California Healthy Building Study: A status report (1994)

the CHBS and compiles currently available results. Phase 2 activities were limited to inspections and low cost measurements that yielded additional information that could be used in conjunction with the Phase-1 symptom data or provided valuable experience of information for future research. Because much of the Phase-2 effort was devoted to evaluation of measurement methodologies or collection of information that will be used in conjunction with the Phase-1 symptom data or provided valuable experience or information for future research. Because much of the Phase-2 effort was devoted to evaluation of measurement methodologies or collection of information that will be used in conjunction with the Phase-1 symptom data, this report is intended primarily for internal use by the CHBS research team.
LOW MOLECULAR WEIGHT HEPARIN PREVENTS THE PULMONARY HEMODYNAMIC AND PATHOMORPHOLOGIC EFFECTS OF ENDOTOXIN IN A PORCINE ACUTE LUNG INJURY MODEL (1998)

Tumor necrosis factor alpha (TNF-alpha) activity, platelet and neutrophil degranulation and margination, and increased vascular permeability are central to the pathophysiology of endotoxin-mediated acute lung injury. Nonanticoagulant activities of low molecular weight heparin (LMWH) include solubilization of the TNF-alpha receptor protein, inhibition of neutrophil adhesion, and regulation of thromboxane B2 (TXB2) biosynthesis. In this study, we evaluated the ability of LMWH to modulate TNF-alpha and TXB2 activity during endotoxemia and the subsequent effects on pulmonary hemodynamics. Domestic pigs 8-10 weeks old were anesthetized and catheterized for standard cardiopulmonary measurements and the lungs harvested for cuff:vessel ratio, myeloperoxidase activity, and permeability index. Pigs were randomly assigned to one of four groups: lipopolysaccharide (LPS) (n = 6), given .5 microg/kg/h Escherichia coli LPS intravenously for 6 h; saline control (n = 5); LMWH (n = 5), given .5 mg/kg LMWH for 30 min, followed by .5 mg/kg/h; and LMWH + LPS (same dosages, n = 6). Administration of LPS resulted in increased plasma TNF-alpha and TXB2 activity; increased pulmonary arterial pressure, pulmonary vascular resistance, and alveolar-arterial oxygen tension; decreased systemic arterial oxygen tension; and pulmonary edema. The cardiopulmonary parameters for the LMWH-treated pigs did not differ from those of the saline-treated control pigs. Pretreatment with LMWH attenuated the LPS-mediated TNF-alpha and TXB2 activity and attenuated LPS-mediated pulmonary hypertension, hypoxemia and neutrophil emigration, and edema formation. In conclusion, the data show that the protective effects of LMWH in this model of acute lung injury are associated with altered neutrophil adhesion and TNF-alpha and thromboxane activity.
Automated Postprocessing of Electrospray LC/MS Data for Profiling Protein Expression in Bacteria (2002)

We describe an integrated approach for automating protein analysis of bacterial cell extracts. The method uses electrospray LC/MS to generate chromatographic profiles of proteins present in an extract, along with a software program that automates the data analysis. The software program, Retana, automates the sequential summing, centroiding, and deconvolution of multiply charged proteins present in consecutive scans of the LC/MS analysis. This procedure generates a concise, single spectrum of proteins present in the extract, along with their retention time and relative abundance. A comparison of the method with "whole cell" MALDI analysis demonstrates improved mass resolution and mass accuracy, along with the appearance of a greater number of proteins. Additionally, it is possible to compare protein expression among strains of bacteria by normalizing the relative abundance of similar proteins in each analysis.
Formation, Accumulation, and Hydrolysis of Endogenous and Exogenous Formaldehyde-Induced DNA Damage (2020)

Formaldehyde is not only a widely used chemical with well-known carcinogenicity but is also a normal metabolite of living cells. It thus poses unique challenges for understanding risks associated with exposure. N2-hydroxymethyl-dG (N2-HOMe-dG) is the main formaldehyde-induced DNA mono-adduct, which together with DNA-protein crosslinks (DPCs) and toxicity-induced cell proliferation, play important roles in a mutagenic mode of action for cancer. In this study, N2-HOMe-dG was shown to be an excellent biomarker for direct adduction of formaldehyde to DNA and the hydrolysis of DPCs. The use of inhaled [13CD2]-formaldehyde exposures of rats and primates coupled with ultrasensitive nano ultra performance liquid chromatography-tandem mass spectrometry permitted accurate determinations of endogenous and exogenous formaldehyde DNA damage. The results show that inhaled formaldehyde only reached rat and monkey noses, but not tissues distant to the site of initial contact. The amounts of exogenous adducts were remarkably lower than those of endogenous adducts in exposed nasal epithelium. Moreover, exogenous adducts accumulated in rat nasal epithelium over the 28-days exposure to reach steady-state concentrations, followed by elimination with a half-life (t1/2) of 7.1 days. Additionally, we examined artifact formation during DNA preparation to ensure the accuracy of nonlabeled N2-HOMe-dG measurements. These novel findings provide critical new data for understanding major issues identified by the National Research Council Review of the 2010 Environmental Protection Agency’s Draft Integrated Risk Information System Formaldehyde Risk Assessment. They support a data-driven need for reflection on whether risks have been overestimated for inhaled formaldehyde, whereas underappreciating endogenous formaldehyde as the primary source of exposure that results in bone marrow toxicity and leukemia in susceptible humans and rodents deficient in DNA repair.
Supplementary Figure 5 - Activity of targeted (XE) and non-targeted (KSF) mTNF, hIL2 and mIFNa2 in BALB/c mice bearing CT26 tumors transfected with human CAIX. from Antibody-Based Delivery of Cytokine Payloads to Carbonic Anhydrase IX Leads to Cancer Cures in Immunocompetent Tumor-Bearing Mice (2023)

&lt;p&gt;a, b, c) Tumor bearing mice received three injections of either 2 Âµg XE-mTNF or 2 Âµg KSF-mTNF(a), 30 Âµg XE-hIL2 or 30 Âµg KSF-hIL2(b) or 80 Âµg XE-mIFNa2 or 80 Âµg KSF-mIFNa2(c)or saline (PBS) as control, starting when tumors reached a size of 90 mm3. Data are represented as mean (n=3) + SEM. Statistical significance is shown on day 15, n.s.=non-significant, *p&lt;0.05, ***p&lt;0.0005, ****p&lt;0.0001. d, e, f) Body weight change during the treatment phase of the therapies depicted in a, b, c. g) Pictures of representative tumor growth taken before (day 7) and after treatment (day 12).&lt;/p&gt;
Unassisted HI photoelectrolysis using n-WSe2solar absorbers (2015)

Molybdenum and tungsten diselenide are among the most robust and efficient semiconductor materials for photoelectrochemistry, but they have seen limited use for integrated solar energy storage systems. Herein, we report that n-type WSe2 photoelectrodes can facilitate unassisted aqueous HI electrolysis to H2(g) and HI3(aq) when placed in contact with a platinum counter electrode and illuminated by simulated sunlight. Even in strongly acidic electrolyte, the photoelectrodes are robust and operate very near their maximum power point. We have rationalized this behavior by characterizing the n-WSe2|HI/HI3 half cell, the Pt|HI/H2||HI3/HI|Pt full cell, and the n-WSe2 band-edge positions. Importantly, specific interactions between the n-WSe2 surface and aqueous iodide significantly shift the semiconductor's flatband potential and allow for unassisted HI electrolysis. These findings exemplify the important role of interfacial chemical reactivity in influencing the energetics of semiconductor-liquid junctions and the resulting device performance.
Sabatier Methanation Reactor for Space Exploration (2005)

The Sabatier Methanation Reactor technology is of vital importance to the success of the human and robotic exploration program. In order to achieve an affordable program, the logistics supply to support the mission must be minimized to the fullest extent possible. One area of potential reduction with high return on investment is the closure of life support loops, particularly oxygen and water. The Sabatier system accomplishes this by utilizing hydrogen and carbon dioxide, waste products from the life support system, to produce water and methane. The recovered water is then recycled back into the life support system to provide oxygen; while the methane can be used for propulsion, or can be broken down further to recover the hydrogen. This technology is applicable not only to transit phases of exploration, but surface habitats as well as in-situ propellant production. The Sabatier Reactor system has been developed for ground based demonstration experiments extensively over the past 30 years. Over the past three years, NASA has funded development of the Sabatier Carbon Dioxide Reduction Assembly (CRA) for use on the ISS. Currently this system is at TRL 5 and it is expected that the system will be flown on the ISS as a flight experiment, The purpose of the flight experiment is to integrate the Sabatier CRA into a synchronized system with the oxygen generation system and the carbon dioxide concentrator. The flight experiment will verify the integration of the different systems working together plus it will verify the capability of the system to operate, and effectively separate its products in a micro-gravity environment. Subsequent to design validation, the flight experiment can remain onboard the ISS providing valuable water to offset logistics re-supply requirements. Some of the challenges facing the development of the Sabatier system include handling vibration induced particulates, microgravity phase separation and containment of hazardous gases. Plans for adequately addressing these issues will be presented. The Sabatier carbon dioxide reduction process will greatly benefit any of the extended duration human exploration missions because of the tremendous savings of consumables realized. Any of these mission scenarios, be they transit or surface based, must consider closing the life support loops in order to make the mission achievable, let alone affordable. Carbon dioxide reduction technology will be necessary for future outpost habitats, and the technology needs to be proven viable in a space application. The Sabatier methanation reaction is also a desirable method for producing propellant from the Mars atmosphere. The common system could be designed to accept carbon dioxide from an indoor air revitalization loop concentrator, or from an outdoor atmosphere compressor. Carbon dioxide reduction validation is but one step in the spiral development of the in-situ propellant production system desired for future planetary exploration.
Applied Geophysics second edition (1990)

Ini adalah versi yang sepenuhnya direvisi dan diperbarui dari buku teks populer dan sangat dihormati, Geofisika Terapan. Ini menjelaskan metode fisik yang terlibat dalam eksplorasi hidrokarbon dan mineral, yang meliputi metode gravitasi, magnet, seismik, listrik, elektromagnetik, radioaktivitas, dan well-logging. Semua aspek dari metode ini dijelaskan, termasuk teori dasar, peralatan lapangan, teknik akuisisi data, pemrosesan dan interpretasi data, dengan tujuan untuk menemukan endapan komersial mineral, minyak, dan gas serta menentukan luasnya. Dalam empat belas tahun atau lebih sejak edisi pertama Geofisika Terapan, banyak perubahan telah terjadi di bidang ini, terutama sebagai hasil dari teknik baru, instrumentasi yang lebih baik, dan peningkatan penggunaan komputer di lapangan dan dalam interpretasi data. Para penulis menjelaskan perubahan ini dengan sangat rinci, termasuk metode yang lebih baik untuk memecahkan masalah terbalik, metode seismik khusus, magnetotelurik sebagai metode eksplorasi praktis, metode elektromagnetik domain waktu, peningkatan penggunaan spektrometer sinar gamma, dan peningkatan metode well-logging dan penafsiran.
An Update on the Epigenetics of Glioblastomas (2016)

Glioblastomas, also known as glioblastoma multiforme (GBM), are the most aggressive and malignant type of primary brain tumor in adults, exhibiting notable variability at the histopathological, genetic and epigenetic levels. Recently, epigenetic alterations have emerged as a common hallmark of many tumors, including GBM. Considering that a deeper understanding of the epigenetic modifications that occur in GBM may increase the knowledge regarding the tumorigenesis, progression and recurrence of this disease, in this review we discuss the recent major advances in GBM epigenetics research involving histone modification, glioblastoma stem cells, DNA methylation, noncoding RNAs expression, including their main alterations and the use of epigenetic therapy as a valid option for GBM treatment.
Synthese und Struktur von einem neuartigen cyclischen Carben‐Komplex (1983)

Abstract Das vollständige Manuskript dieser Zuschrift erscheint in: Angew. Chem. Suppl. 1983 , 488. DOI: 10.1002/ange.198304880
Patients’ Perceptions Regarding the Relevance of Items Contained in the Functional Assessment of Cancer Therapy Kidney Symptom Index-19 (2023)

There is a need to refine widely used HR-QOL measures that are employed among patients diagnosed with mRCC treated with contemporary therapies. Guidance was provided for the inclusion of more relevant items to patients' cancer journey.
3D Elastic Seismic Modeling of Large Scale Land Survey (2019)

Abstract We present a software framework tailored to seismic applications embedding high performance features. Especially, we discuss the spatial cache-blocking algorithm for the Finite-Difference Time-Domain (FDTD) method and the protocol to find optimal parameters. We apply our modeling engine to perform 3D elastic seismic modeling on a large-scale 877 km2 land survey. The velocity and density models are built with geological stratigraphic forward modeling. In total, 162300 shot gathers are computed with a maximum frequency of 20Hz and a maximum offset of 5 km. The main trait of the computed data is the complexity related to the surface-waves, especially their long and dispersive wave-train obscuring other wave arrivals. Computations were performed on the Kaust supercomputer Shaheen II. The modeling campaign took one month to complete using in average 2434 compute nodes in parallel. This achievement represents a workload of 59.6 ExaFLOP on a current PetaFLOP/s machine. This indicates that the next generation of supercomputers targeting the ExaFLOP/s sustained performance, would allow reducing the run-time of our application to one hour or less. With such performance, it is reasonable to predict that 3D elastic imaging will be a routinely used algorithm by seismic exploration in the years to come, while nowadays it still requires leading-edge hardware.
Mortality secondary to esophageal anastomotic leak. (2004)

Postoperative esophageal anastomotic leaks prove fatal in a significant number of cases. The lethal potential of cervical anastomotic leaks should not be underestimated. Gastric necrosis is an important predictor of subsequent death. Advanced age, early postoperative (<7 days) leakage, and clinically apparent signs of leakage may be predictive of death but these factors did not reach statistical significance in our study. Surgical treatment of esophageal anastomotic leaks is associated with subsequent death, but this relationship is unlikely to be causal; severely ill patients tend to be treated surgically.
Fast Approximate L_infty Minimization: Speeding Up Robust Regression (2013)

Minimization of the $L_\infty$ norm, which can be viewed as approximately solving the non-convex least median estimation problem, is a powerful method for outlier removal and hence robust regression. However, current techniques for solving the problem at the heart of $L_\infty$ norm minimization are slow, and therefore cannot scale to large problems. A new method for the minimization of the $L_\infty$ norm is presented here, which provides a speedup of multiple orders of magnitude for data with high dimension. This method, termed Fast $L_\infty$ Minimization, allows robust regression to be applied to a class of problems which were previously inaccessible. It is shown how the $L_\infty$ norm minimization problem can be broken up into smaller sub-problems, which can then be solved extremely efficiently. Experimental results demonstrate the radical reduction in computation time, along with robustness against large numbers of outliers in a few model-fitting problems.
Synthesis of carbon‐14‐labelled antibacterial agent. Synthesis of 1‐ethyl‐ [1‐14C]‐6‐fluoro‐1, 4‐dihydro‐4‐oxo‐7‐ (1‐piperazinyl)‐3‐quinolinecarboxylic acid (14C‐AM‐715) (1981)

Abstract 1‐Ethyl‐6‐fluoro‐1,4‐dihydro‐4‐oxo‐7‐(1‐piperazinyl)‐ 3‐quinolinecarboxylic acid ( I , AM‐715), a new potent antibacterial agent, was labelled with carbon‐14 at the C‐1 position of the N‐ethyl group for metabolic studies. The synthesis was achieved according to two reaction routes. The overall radiochemical yields of 14 C‐AM‐715 based on ethyl iodide‐1‐ 14 C from route A and route B, were 29.4% and 9.4%, respectively.
Polimeri funzionali:aspetti strutturali, sintesi ed applicazioni nel settore tecnologico-farmaceutico (2007)

Dottorato di Ricerca in Metodologie per lo Sviluppo di Molecole di Interesse,Ciclo XX 2006-2007, a.a.2006-2007
Mesoscopic self-organization of a self-assembled supramolecular rectangle on highly oriented pyrolytic graphite and Au(111) surfaces (2005)

A self-assembled supramolecular metallacyclic rectangle was investigated with scanning tunneling microscopy on highly oriented pyrolytic graphite and Au(111) surfaces. The rectangles spontaneously adsorb on both surfaces and self-organize into well ordered adlayers. On highly oriented pyrolytic graphite, the long edge of the rectangle stands on the surface, forming a 2D molecular network. In contrast, the face of the rectangle lays flat on the Au(111) surface, forming linear chains. The structures and intramolecular features obtained through high-resolution scanning tunneling microscopy imaging are discussed.
Data from HIF2 Inactivation and Tumor Suppression with a Tumor-Directed RNA-Silencing Drug in Mice and Humans (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;HIF2α is a key driver of kidney cancer. Using a belzutifan analogue (PT2399), we previously showed in tumorgrafts (TG) that ∼50% of clear cell renal cell carcinomas (ccRCC) are HIF2α dependent. However, prolonged treatment induced resistance mutations, which we also identified in humans. Here, we evaluated a tumor-directed, systemically delivered, siRNA drug (siHIF2) active against wild-type and resistant-mutant HIF2α.&lt;/p&gt;Experimental Design:&lt;p&gt;Using our credentialed TG platform, we performed pharmacokinetic and pharmacodynamic analyses evaluating uptake, HIF2α silencing, target gene inactivation, and antitumor activity. Orthogonal RNA-sequencing studies of siHIF2 and PT2399 were pursued to define the HIF2 transcriptome. Analyses were extended to a TG line generated from a study biopsy of a siHIF2 phase I clinical trial (NCT04169711) participant and the corresponding patient, an extensively pretreated individual with rapidly progressive ccRCC and paraneoplastic polycythemia likely evidencing a HIF2 dependency.&lt;/p&gt;Results:&lt;p&gt;siHIF2 was taken up by ccRCC TGs, effectively depleted HIF2α, deactivated orthogonally defined effector pathways (including Myc and novel E2F pathways), downregulated cell cycle genes, and inhibited tumor growth. Effects on the study subject TG mimicked those in the patient, where HIF2α was silenced in tumor biopsies, circulating erythropoietin was downregulated, polycythemia was suppressed, and a partial response was induced.&lt;/p&gt;Conclusions:&lt;p&gt;To our knowledge, this is the first example of functional inactivation of an oncoprotein and tumor suppression with a systemic, tumor-directed, RNA-silencing drug. These studies provide a proof-of-principle of HIF2α inhibition by RNA-targeting drugs in ccRCC and establish a paradigm for tumor-directed RNA-based therapeutics in cancer.&lt;/p&gt;&lt;/div&gt;