gebhart/patrepeval huggingface dataset:
A Deterministic Distributed $2$-Approximation for Weighted Vertex Cover in $O(\log n\logΔ/ \log^2\logΔ)$ Rounds (2018)

This paper presents a deterministic distributed algorithm for computing an f(1+epsilon) approximation of the well-studied minimum set cover problem, for any constant epsilon>0, in O(log (f Delta)/log log (f Delta)) rounds. Here, f denotes the maximum element frequency and Delta denotes the cardinality of the largest set. This f(1+epsilon) approximation almost matches the f-approximation guarantee of standard centralized primal-dual algorithms, which is known to be essentially the best possible approximation for polynomial-time computations. The round complexity almost matches the Omega(log (Delta)/log log (Delta)) lower bound of Kuhn, Moscibroda, Wattenhofer [JACM'16], which holds for even f=2 and for any poly(log Delta) approximation. Our algorithm also gives an alternative way to reproduce the time-optimal 2(1+epsilon)-approximation of vertex cover, with round complexity O(log Delta/log log Delta), as presented by Bar-Yehuda, Censor-Hillel, and Schwartzman [PODC'17] for weighted vertex cover. Our method is quite different and it can be viewed as a locality-optimal way of performing primal-dual for the more general case of set cover. We note that the vertex cover algorithm of Bar-Yehuda et al. does not extend to set cover (when f >= 3).
Supplementary Data from Deep Learning Based on Standard H&E Images of Primary Melanoma Tumors Identifies Patients at Risk for Visceral Recurrence and Death (2023)

Supplementary Data from Deep Learning Based on Standard H&amp;E Images of Primary Melanoma Tumors Identifies Patients at Risk for Visceral Recurrence and Death
Population Diversity of Particle Swarms (2008)

In the field of evolutionary computation, an important attribute of a population is diversity. This paper proposes a method for measuring the diversity of a particle swarm optimization population. It involves the measurement of position and velocity attributes of the particles that comprise the population. The proposed method is computationally straightforward and is adaptable to other evolutionary algorithms.
Fecal carriage and characterization of extended-spectrum β-lactamase- and AmpC β-lactamase-producing Escherichia coli from healthy horses in France (2017)

Fecal carriage and characterization of extended-spectrum β-lactamase- and AmpC β-lactamase-producing [i]Escherichia coli[/i] from healthy horses in France. 7. Symposium on Antimicrobial Resistance in Animals and the Environment (ARAE)
Limits of detection for silicon nanowire BioFETs (2012)

Over the past decade, silicon nanowire/nanoribbon field-effect transistors (NWFETs) have demonstrated phenomenal sensitivity to the detection of biomolecular species, with limits of detection (LOD) down to femtomolar concentrations [1].However, a fundamental understanding of these limits has been lacking until now. Several well known factors limit the LOD; among them, ionic concentration, efficiency of the biomolecule-specific surface functionalization, binding constants, and the delivery of the analyte to the sensor surface. However, the signal-to-noise ratio (SNR) of these bioFET sensors, and the device parameters that determine the LOD, are not well understood. For example, it has been commonly claimed [2] that NWFET sensitivity is maximized in the subthreshold operating regime of the device. We show here, contrary to this claim, that the SNR is maximized at maximum transconductance due to the effects of 1/f noise. These devices currently have a LOD of 4 electronic charges in ambient conditions…
Oxidation of p-Dimethylaminobenzaldehyde Semicarbazone. Novel Conversion of an Aromatic Aldehyde to an Aroyl Cyanide (1972)

Oxidation of the semicarbazone of p-dimethylaminobenzaldehyde with lead tetraacetate affords p-dimethylaminobenzoyl cyanide. Probable intermediates are an iminooxadiazoline and an iminooxirane.
Supplementary Figure 4 from WEE1 Inhibition Alleviates Resistance to Immune Attack of Tumor Cells Undergoing Epithelial–Mesenchymal Transition (2023)

&lt;p&gt;PDF file - 26KB, Figure S4. Resistance of brachyury-high tumor cells could be alleviated by WEE1 inhibition.&lt;/p&gt;
High frequency jet ventilation in horses: an experimental study (1989)

High frequency jet ventilation (HFJV) is a recently developed mode of ventilation that delivers small tidal volumes at frequencies greater than 60 cycles per min via an injection catheter to the animal's airway. The construction of a high frequency jet ventilator suitable for use in adult horses is described. The effectiveness of this ventilator in maintaining normal arterial blood-gas tension was evaluated in five healthy adult horses. The horses were anaesthetised with intravenous acetylpromazine, guaifenesin, and thiamylal, positioned in lateral recumbency and baseline measurements were made during spontaneous ventilation. The horses were then paralysed with succinylcholine and ventilated for at least 20 mins with HFJV. Air was delivered from the ventilator to the animal by a polyethylene tube. The tip of this tube remained within and approximately 30 cm from the cuffed end of a standard 30 mm internal diameter large animal orotracheal tube. Frequency of flow interruption was 3 Hz with a constant source pressure of 275 kPa and an inspiratory to expiratory ratio of approximately 1:2.6. Gas delivery to the horse, as estimated with a resonator system was approximately 2 litres/breath. During HFJV, arterial carbon dioxide tension was significantly reduced and arterial oxygen tension significantly increased above measurements made when the horses were spontaneously breathing air.
Microbiome of the Paranasal Sinuses: Update and Literature Review (2016)

The advent of culture-independent molecular approaches has led to a greater appreciation of the intricate microbial ecology of the paranasal sinuses. Microbiota composition, distribution, and abundance impact mucosal health and influence pathogen growth and function. A deeper understanding of the host-microbiome relationship and its constituents may encourage development of new treatment paradigms for CRS, which target restoration of microbiome homeostasis and cultivation of optimal microbial communities.
Feasibility study of a circularly towed cable-body system for UAV applications (2016)

This paper presents a feasibility study for end-body positioning maneuvers using a towed cable-body system where a fixed wing Unmanned Aerial Vehicle (UAV) is stabilized in a steady-state circular motion. As high precision maneuvers such as object pickup/dropoff are typically performed by rotorcraft UAVs, a successful fixed-wing concept would greatly increase the possible range for this type of operation and enable missions into more remote locations. Circularly towed cable-body systems have been shown capable, both analytically and experimentally, of maintaining equilibrium configurations with the towed endbody stabilized in a small orbit respective to a point on the ground. However, no known efforts consider small to medium scale UAV operations for object pickup/dropoff. It is a primary goal of this paper to identify key parameters to consider when selecting a UAV and towcable system to use for high precision maneuvers, specifically to consider the achievable steady state configurations for circularly towed UAV systems. The equations of motion for the towed cable are developed based on a Lumped Parameter Model (LPM). An optimization problem was formulated in order to determine configuration parameters for the towed system that minimizes the steady-state orbit of the towed endbody while staying within the performance constraints that apply to the towing UAV. It is shown feasible to achieve sufficiently small orbits of the endbody to warrant considering the concept further for precision maneuvers.
A neuromuscular platform to extract electrophysiological signals from lesioned nerves: a technical note. (2002)

The volitional control of prosthetic devices could be greatly enhanced if the information formerly supplied by peripheral nerves to the amputated limb could be utilized. So that practical access to this information could be gained, a method was established to form a stable biological interface with fascicles of lesioned nerves. A small strip of an intact muscle was isolated in rats with the use of a silicone tube cuff electrode and innervated by the lesioned peroneal branch of the sciatic nerve. After 4 weeks survival, stimulation of the nerve fascicle produced reliable signals from the neuromuscular platform in the range of 0.5 to 2.0 mV. Histologically, myotubes remained intact and axons could be identified growing in and over the surfaces of the isolated muscle strips. These or similar interface techniques may supply electrophysiological signals of sufficient amplitude and reliability to provide peripheral nerve-based guidance information for prosthetic devices.
Electron attachment to the perfluoroalkanes n-CNF2N+2 (N=1–6) and i-C4F1 a) (1983)

Parent and fragment negative ion formation from seven perfluoroalkanes [n-CNF2N+2 (N=1–6) and i-C4F10] under low-energy (0–10 eV) electron impact has been studied using a time-of-flight mass spectrometer. For CF4, C2E6, and C3F8 only fragment anions were observed, F− being the most abundant. For n-C4F10 a weak parent ion was observed, but again the predominant ion was F−. For i-C4F10, n-C5F12, and n-C6F14 the parent negative ions were the most abundant with relative cross sections peaking at 0.6 eV and autodetachment lifetimes from 10 to 100 μs depending on the molecular size and electron energy. In addition to the parent negative ion and the F− ion, fragment negative ions of the form CNF−2N+1, CNF−2N, CNF−2N−1 (with N=1–6) have been detected. The relative cross sections for all observed negative ions have been measured and corrected for the finite width of the electron pulse using an unfolding procedure. The positions of the dissociating negative ion states (NISs) shift to lower energies with increasing size of the molecule. Possible fragmentation mechanisms of the NISs leading to the production of the observed fragment negative ions have been suggested and discussed. From the appearance onsets of a number of fragment negative ions, various C–C and C–F bond dissociation energies, heats of formation, and electron affinities EA of certain fragments have been determined and are reported. It was found that the EA of perfluorocarbon radicals increases with increasing size of these radicals, and similar behavior is indicated also for the perfluoroalkane molecules themselves. The separation times of the dissociating fragments and the autodetachment lifetimes of the extremely short-lived (∼10−15 s) and dissociating NISs of CF4 and C2F6 were estimated. The intensity of the parent anion as a function of molecular size and geometry is discussed, and the relative intensities of the fragment negative ions are rationalized on the basis of the present work and relevant data from electron swarm studies.
Most accurate algorithms for RSS-based Wi-Fi indoor localisation (2014)

Since Wi-Fi transceivers are available in most handheld devices, they are well suited for indoor localisation. This article analyses the relevance of thirteen factors of model based received signal strength indoor-localisation algorithms on localisation accuracies and identifies for each of these factors algorithms or parameter-settings that achieve high position accuracy. In order to assure the results' meaningfulness and comparability, these factors' optima have been identified via trace-driven empirical studies. By comparing position accuracies of the optimised optLoc localisation algorithm and of the Radar algorithm, a significant increase of accuracy was shown. In case of the optLoc algorithm, error distances dropped by ca. 1m and localisation-error rates decreased also significantly. In addition, the article studies energy efficiency of Wi-Fi based indoor localisation and identifies the most energy efficient approach.
New approach to Genomics Experiments Taking Advantage of Virtual Laboratory System (2009)

Specialized software, on-line tools and computational resources are very common in contemporary science. One of the exemplary domain is genomics -a new branch of science that developed rapidly in the last decade. As the genome research is very complex, it must be supported by professional informatics. In a microarray field the following steps cannot be performed without computational work: design of probes, quantitative analysis of hybridization results, post-processing, and finally data storage and management. Here, the general aspects of virtual laboratory systems are presented together with perspectives of their implementation in genomics in order to automate and facilitate this area of research.
An Extension of the Burrows Wheeler Transform to k Words (2005)

Summary form only given. We introduce an extension of the Burrows-Wheeler transform to a multiset of primitive words. Primitiveness is not actually a restrictive hypothesis, since in practice almost all the processed texts are primitive (or become primitive by adding an end-of-string symbol). We prove that such a transformation as the BWT is reversible. We show how to use the transformation as a preprocessing for the simultaneous compression of different texts.
Pacing in magnetic resonance imaging environment: Clinical and technical considerations on compatibility (2001)

Magnetic resonance imaging is a widely accepted tool for the diagnosis of a variety of disease states. However, the presence of an implanted pacemaker is considered to be a strict contraindication to magnetic resonance imaging in the vast majority of medical centres, precluding a substantial and growing number of patients from the diagnostic advantages of this imaging modality. The potential effects of magnetic resonance imaging on cardiac pacemakers are multiple (Table 1). The static magnetic field may close the reed switch, resulting in asynchronous pacing. The radiofrequency field may induce an undesirable fast pacing rate. The time-varying magnetic gradient fields may induce currents in the pacemaker system of sufficient magnitude to pace the heart. There are other theoretical concerns, including potential thermal injury at the lead tip. However, the most influential factor that supports the current practice is the reported lethal consequences of magnetic resonance imaging in patients with implanted pacemakers. Despite the above-mentioned concerns, the effects of magnetic resonance imaging on cardiac pacemakers remain controversial. Most of the previous studies that prohibit magnetic resonance imaging in pacemaker patients were based on in vitro and animal model data from the 1980’s using older pacemaker and lead technology. More recent anecdotal reports describe a small series of pacemaker patients who have safely
A 240 W doherty GaAs power FET amplifier with high efficiency and low distortion for W-CDMA base stations (2004)

An L/S-band 240 W Doherty GaAs FET amplifier with high efficiency and low distortion has been successfully developed. The amplifier employed a simple 2-way Doherty configuration to our plastic-packaged GaAs heterojunction FETs (HJFETs). We optimized load impedance shift of the main and the peak amplifiers as a function of input power level utilizing load-pull measurement and large signal simulation. The developed Doherty amplifier demonstrated low adjacent channel leakage power ratio (ACPR) of less than -34 dBc with a power-added efficiency (PAE) of 34% at an output power (Pout) of 45 dBm with a W-CDMA signal at 2.14 GHz. It also showed 53.8 dBm saturation output power with 11.2 dB linear gain. It achieved efficiency enhancement more than 11% compared to the conventional push-pull configuration under the same ACPR conditions. To our knowledge, these represent the best results ever reported among the high power FET amplifiers for W-CDMA base stations.
Poster 1013: IL-4R alpha antibody inhibits IgE production and airway remodeling in mouse model of house dust mite-induced eosinophilic asthma (2014)

This article was originally published online on 03 February 2014 Allergic asthma is associated with T helper 2 (Th2) immune response to an allergen. IL-4 and IL-13, key cytokines involved in Th2 immunity, promote eosinophilic inflammation and B cell isotype switching to IgE. House Dust Mite (HDM) allergen has been shown to induce allergic asthma in a mouse model via Th2 immune response that drives eosinophilia and influx of effector T cells into lung. An IL-4Raplha antibody that blocks signaling of IL-4 and IL-13 through both Type I (IL-4Ralpha/IL-2Rgamma) and Type II (IL-4Ralpha/IL-13R) receptors, and an IL-13Rα2-Fc fusion protein that prevents binding and signaling of IL-13 via Type II receptor, were both tested in the HDM-induced mouse model of asthma. Mice were sensitized daily for 10 days with HDM, rested for 2 weeks, followed by challenge with HDM three times weekly for 8 weeks. Both anti-mouse IL-4Ralpha; antibody (Ab) and fully human anti-human IL-4Raplha Ab (dupilumab) were tested in wild type mice and mice humanized for IL-4 and IL-4Ralpha, respectively. Mice were treated with 50 mg/kg of either Ab twice weekly, starting at week 7 of the experiment. A separate group received mouse IL-13Raplha2-Fc protein using the same dose and regimen. At the end of the experiment, cells obtained by left lung lobe tissue digest were analyzed by flow cytometry. Lung collagen indicative of an airway remodeling was quantified using a Sircol Dye assay, and cardiac lung lobe was used for microarray analysis of gene signature. Levels of HDM-specific IgG1 and total IgE in serum were analyzed by ELISA. HDM sensitization and challenge resulted in increased levels of IgE and HDM-specific IgG1. IgE increase was blocked by IL-4Rα Ab but not by IL-13Ralpha2-Fc treatment; HDM-specific IgG1 levels were not affected by either treatment. Collagen content in lung of mice treated with IL-4Ralpha mAb was similar to that observed in mock sensitized and challenged mice. Dupilumab treatment also prevented the influx of eosinophils and inflammatory dendritic cells into lung. HDM-induced changes in gene expression were largely normalized upon dupilumab treatment, as compared to mock treated and sensitized mice. Our results demonstrate that blockade of IL-4 signaling via Type I and Type II receptors by IL-4Ralpha antibody suppresses inflammatory and fibrotic changes in lungs of HDM-challenged mice as well as gene signature changes driven by HDM.
Transgastric NOTES for the Detection of Peritoneal Carcinomatosis: More Targets Needed for a Thorough Evaluation (2010)

Ladjici, Yamina MD; Pocard, Marc MD, PhD; Marteau, Philippe MD, PhD; Valleur, Patrice MD; Dray, Xavier MD, PhD Author Information
Equality, Liberty, and Perfectionism By Vinit Haksar Clarendon Press: Oxford University Press, 1979, viii + 302 pp., £12 (1981)

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Advances in the understanding and clinical management of mastocytosis and clonal mast cell activation syndromes (2016)

Clonal mast cell activation syndromes and indolent systemic mastocytosis without skin involvement are two emerging entities that sometimes might be clinically difficult to distinguish, and they involve a great challenge for the physician from both a diagnostic and a therapeutic point of view. Furthermore, final diagnosis of both entities requires a bone marrow study; it is recommended that this be done in reference centers. In this article, we address the current consensus and guidelines for the suspicion, diagnosis, classification, treatment, and management of these two entities.
Contextual weighting for vocabulary tree based image retrieval (2011)

In this paper we address the problem of image retrieval from millions of database images. We improve the vocabulary tree based approach by introducing contextual weighting of local features in both descriptor and spatial domains. Specifically, we propose to incorporate efficient statistics of neighbor descriptors both on the vocabulary tree and in the image spatial domain into the retrieval. These contextual cues substantially enhance the discriminative power of individual local features with very small computational overhead. We have conducted extensive experiments on benchmark datasets, i.e., the UKbench, Holidays, and our new Mobile dataset, which show that our method reaches state-of-the-art performance with much less computation. Furthermore, the proposed method demonstrates excellent scalability in terms of both retrieval accuracy and efficiency on large-scale experiments using 1.26 million images from the ImageNet database as distractors.
Les tissus adipeux, notamment intermusculaires, sont le siège de la synthèse et de la bioconversion du 9CIS,11TRANS CLA chez le bouvillon (2006)

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Estimation of the Extent ofin VivoFormation of a Mutagenic Aromatic Amine from a Potent Thyromimetic Compound: Correlation ofin Vitroandin VivoFindings (2011)

The development of compounds with the potential for genotoxicity poses significant safety risks as well as risks of attrition. Although genotoxicity evaluation of the parent molecule is routine and reasonably predictive, assessing the risk of commercialization when release of a genotoxic degradant and/or metabolite from a nongenotoxic parent molecule is suspected is much more challenging and resource intensive. Much of the risk of the formation of a genotoxic degradant/metabolite can be discharged with the conduct of carcinogenicity studies in models where the compound is formed, but this approach requires a great deal of time and resources. In this manuscript, we investigated the contribution of various factors (pH, serum instability, and hepatic metabolism) to the formation of a mutagenic aromatic amine from a potent and highly selective thyromimetic compound ([3-(3,5-dibromo-4-(4-hydroxy-3-isopropyl-5-methylphenoxy)-2-methylphenylamino)-3-oxopropanoic acid], compound 1), under in vitro conditions. The kinetic parameters obtained from in vitro experiments combined with the pharmacokinetics of 1in vivo (e.g., plasma concentration-time profile and clearance) were used to estimate the extent of in vivo formation of [4-(4-amino-2,6-dibromo-3-methylphenoxy)-2-isopropyl-6-methylphenol] (compound 2), in rats upon administration of a single oral dose of 1. The agreement between the predicted values (1.9% conversion of total administered dose) with the observed levels of 2 in rats (0.2%-2.2% of the 10 mg/kg dose, 10 mg/kg) further prompted the utilization of this approach to predict the extent of release of this mutagen in humans upon administration of 1. The projection of 0.13% conversion to 2 from an efficacious daily dose of 15 mg of 1 translated to the generation of 20 μg of 2 and provided the basis for the decision to terminate the development of 1.
All-optical linear detection for optical CDMA communication systems (2002)

All-optical linear multiuser detectors for optical direct detection CDMA are presented. It is found that under certain constraints all the weights of a linear FIR filter detector are 0-1. The performance of these detectors is examined using large deviations theory.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>