gebhart/patrepeval huggingface dataset:
Construction from destruction using a photo-triggered self-propagating degradable polyurethane as a one-pot epoxy (2020)

We report a photo-triggered, base generating, base propagating degradable polyurethane that is triggered by 365 nm UV light irradiation.
From stem cell to erythroblast: Regulation of red cell production at multiple levels by multiple hormones (2010)

This article reviews the regulation of production of red blood cells at several levels: (1) the ability of erythropoietin and adhesion to a fibronectin matrix to stimulate the rapid production of red cells by inducing terminal proliferation and differentiation of committed erythroid CFU-E progenitors; (2) the regulated expansion of the pool of earlier BFU-E erythroid progenitors by glucocorticoids and other factors that occurs during chronic anemia or inflammation; and (3) the expansion of thehematopoietic cell pool to produce more progenitors of all hematopoietic lineages.
Improved molecular detection of mosaicism in Beckwith-Wiedemann Syndrome (2020)

This study highlights the prevalence of mosaic disease among individuals with BWSp and the increases in diagnostic yield obtained via testing both blood and solid tissue samples from affected individuals. Additionally, the results establish the presence of a molecular diagnosis in individuals with very subtle features of BWSp.
Functionalization of Fe3O4 magnetic nanoparticles with RGD peptide derivatives (2014)

Derivatives of RGD peptide, such as N?-Pbf-l-Arg-Gly-l-Asp(OAlk)2 (Alk = Me or But), which contain glutaric acid moiety as a linker, were synthesized and immobilized to Fe3O4 magnetic nanoparticles obtained by gas condensation method.
Wet Observations of the DAV G185–32 (2003)

Abstract The pulsating DAV white dwarf G185-32 was observed with the Whole Earth Telescope in 1992, during XCov8. We briefly report on the weighted Fourier transform of the data obtained.
Lower pressure synthesis of diamond material (2023)

Methods of synthesizing a diamond material, particularly nanocrystalline diamond, diamond-like carbon and bucky diamond are provided. In particular embodiments, a composition including a carbon source, such as coal, is subjected to addition of energy, such as high energy reactive milling, producing a milling product enriched in hydrogenated tetrahedral amorphous diamond-like carbon compared to the coal. A milling product is treated with heat, acid and/or base to produce nanocrystalline diamond and/or crystalline diamond-like carbon. Energy is added to produced crystalline diamond-like carbon in particular embodiments to produce bucky diamonds.
INDUCTION OF IMPDH ACTIVITY AFTER LONG-TERM TREATMENT WITH MYCOPHENOLATE MOFETIL (1998)

175 We have systematically studied renal transplant recipients that have been under mycophenolate mofetil (MMF)therapy for different period of time ranging from 2 months to 3 years and performed pharmacokinetic and pharmacodynamic monitoring to assess whether the biological activity of MMF, which should be directly related to the degree of immunosuppression, is maintained even after long-term treatment with MMF. Patients and methods: 13 stable renal transplant recipients were enrolled in the study between 10/96 and 6/97. Patients were treated with MMF at a dose of 2g/day in association with cyclosporin and corticosteroids. Blood samples were collected before and 0.5, 1, 2, 4 and 6 hours after dosing and mycophenolic acid (MPA), the active metabolite of MMF, was measured using a novel EMIT assay while the activity of inosine monophosphate dehydrogenase(IMPDH), a key enzyme in the de novo biosynthesis of purines inhibited by MMF, was determined in whole blood by the estimation of the3 H-release from [2,8-3H] hypoxanthine. Results were expressed as percent of enzyme activity, 100% activity was arbitrary given for the through sample, and results of % activity versus time were plotted. The effects of MMF on IMPDH activity was quantified by measuring the area of the curve under the 100% activity for inhibitory activity and the area of the curve over the 100% activity for stimulatory activity. The results are summarized in the followingtable:Discussion: these results demonstrate that the efficiency of MMF as an inhibitor of IMPDH activity is dramatically reduced as increased the length of MMF therapy. Moreover, this decrease of biological efficacy is associated with an induction of IMPDH activity and a shortening of elimination half time. Such induction could be deleterious if it is followed by a restoration or a stimulation of the proliferative capacity of lymphocytes. These results strongly suggest that the place of MMF in long-term treatment of renal transplant patients need to be reevaluated and that it may be appropriate to include MMF into a drug monitoring program following renal transplantation.
Cochlear Implantation in Patients With Menière's Disease: Does Disease Activity Affect the Outcome? (2020)

CI provides greater gains in functional hearing for patients with MD compared with age-matched controls. Patients with active MD seem to perform better with respect to SRS following CI than patients with inactive status.
Smooth Muscle Cell Alignment and Phenotype Control by Melt Spun Polycaprolactone Fibers for Seeding of Tissue Engineered Blood Vessels (2015)

A method has been developed to induce and retain a contractile phenotype for vascular smooth muscle cells, as the first step towards the development of a biomimetic blood vessel construct with minimal compliance mismatch. Melt spun PCL fibers were deposited on a mandrel to form aligned fibers of 10 μm in diameter. The fibers were bonded into aligned arrangement through dip coating in chitosan solution. This formed a surface of parallel grooves, 10 μm deep by 10 μm across, presenting a surface layer of chitosan to promote cell surface interactions. The aligned fiber surface was used to culture cells present in the vascular wall, in particular fibroblasts and smooth muscle cells. This topography induced "surface guidance" over the orientation of the cells, which adopted an elongated spindle-like morphology, whereas cells on the unpatterned control surface did not show such orientation, assuming more rhomboid shapes. The preservation of VSMC contractile phenotype on the aligned scaffold was demonstrated by the retention of α-SMA expression after several days of culture. The effect was assessed on a prototype vascular graft prosthesis fabricated from polylactide caprolactone; VSMCs aligned longitudinally along a fiberless tube, whereas, for the aligned fiber coated tubes, the VSMCs aligned in the required circumferential orientation.
Third time is the charm - Why the World just might be ready for the Internet of Things this time around (2017)

The technology to connect 'things' to the Internet has existed for more than 20 years, so if we take a look back at recent history we might well be tempted to ask the question why will IoT 'happen' this time around. In this paper we examine the origins of the Internet of Things, answer the question "Why Now?", and look forward to the next wave of disruptive technologies that will be coming to a device near you in the next few years.
A randomized study of natalizumab dosing regimens for relapsing–remitting multiple sclerosis (2021)

Natalizumab 300 mg subcutaneous Q4W was comparable to 300 mg intravenous Q4W dosing with respect to efficacy, pharmacokinetics/pharmacodynamics, and safety.
Temperature and pressure characterization of the quality factor in a CMOS-MEMS resonator (2016)

In this paper, we present a study of the quality factor (Q) behavior of a CMOS-MEMS resonator under different conditions of temperature and pressure. The device has been manufactured using standard 250 nm CMOS technology followed by an in-house BEOL metal-layer release wet etching. The manufactured sensor is used as a pressure estimator based on the variation of Q. Experiments have demonstrated an inverse relationship between the resonator Q and temperature in different pressure regimes. The initial Q has decreased to 0.80*Q at 100 Pa when the temperature changed from 300 K to 360 K, and to 0.65*Q at atmospheric pressure under the same temperature span. The static capacitance variations of the device with temperature have also been measured.
Antibody to human MHC class I inhibits SIVsmmPBj1.9-induced proliferation of pigtailed macaque lymphocytes. (1997)

Previously we have shown that the simian immunodeficiency virus SIVsmmPBj1.9, a molecular clone of SIVsmmPBj14, induces proliferation of human peripheral blood mononuclear cells (PBMC). We have extended this observation to show that SIVsmmPBj1.9 induces proliferation of PBMC from pigtailed macaques. This proliferative response was markedly inhibited by mAbs against human class I MHC, class II MHC and CD4 antigens, and partially inhibited by mAbs against integrin beta 2 subunit (CD18) and LFA-1 (CD11a). However, these antibodies differed in their ability to inhibit in vitro viral infectivity of PBMC. While anti-CD4, MHC class II, and LFA-1 strongly inhibited viral infectivity, antibodies to MHC class I demonstrated little effect on viral infectivity. A control antibody (PLM2) against porcine CD18 inhibited neither virus-induced proliferation nor viral infectivity. Based on these results, we suggest that SIVsmmPBj1.9-induced proliferation requires the participation of class I MHC, class II MHC and CD4 molecules. In addition, the observation that anti-class I MHC Ab inhibited proliferation of macaque PBMC induced by mitogen (PHA) and bacterial superantigens, such as Staphylococcus enterotoxin A and toxin shock syndrome toxin-1, suggests that SIVsmmPBj1.9 also contains a viral superantigen similar to that previously demonstrated in SIVsmmPBj14.
Correction: 9,9′-Anthryl-anthroxyl radicals: strategic stabilization of highly reactive phenoxyl radicals (2015)

Correction for ‘9,9′-Anthryl-anthroxyl radicals: strategic stabilization of highly reactive phenoxyl radicals’ by Tatsuya Aotake <italic>et al.</italic>, <italic>Chem. Commun.</italic>, 2015, DOI: 10.1039/c4cc10104a.
ChemInform Abstract: A Frank Synthesis of Alkyl—Aryl Ethers from 2‐Halobenzaldehydes and Aromatic Olefins Without Transition Metal Co‐Catalyst and Ligand. (2015)

ChemInformVolume 46, Issue 35 Preparative Organic Chemistry ChemInform Abstract: A Frank Synthesis of Alkyl—Aryl Ethers from 2-Halobenzaldehydes and Aromatic Olefins Without Transition Metal Co-Catalyst and Ligand. Balagani Sathish Kumar, Balagani Sathish Kumar Chem. Sci. Div., Cent. Inst. Med. Aromat. Plants, Lucknow 226 015, IndiaSearch for more papers by this authorArvind S. Negi, Arvind S. Negi Chem. Sci. Div., Cent. Inst. Med. Aromat. Plants, Lucknow 226 015, IndiaSearch for more papers by this author Balagani Sathish Kumar, Balagani Sathish Kumar Chem. Sci. Div., Cent. Inst. Med. Aromat. Plants, Lucknow 226 015, IndiaSearch for more papers by this authorArvind S. Negi, Arvind S. Negi Chem. Sci. Div., Cent. Inst. Med. Aromat. Plants, Lucknow 226 015, IndiaSearch for more papers by this author First published: 13 August 2015 https://doi.org/10.1002/chin.201535052Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume46, Issue35September, 2015 RelatedInformation
Formation of multinucleated cells with osteoclast precursor features in human cord monocytes cultures (1990)

A common lineage between monocytes and osteoclasts has been suggested but not yet proved, and an osteoclast precursor might be an immature cell of the monocyte-macrophage family. We therefore compared the ability of cord blood and adult monocytes in long-term culture to differentiate toward osteoclasts. Both adult and cord monocytes were cultured for 3 weeks in the presence of 20% horse serum. The proportion of multinucleated cells formed was influenced by 1,25(OH)2D3 in cord, but not in adult monocyte cultures: 10(-9)M 1,25(OH)2D3 increased multinucleated cells from 13 +/- 2 to 26 +/- 1% of total cells in cord monocyte cultures. The formation of multinucleated cells in cord monocyte cultures, in the presence of 10(-9) M 1,25(OH)2D, was decreased by salmon calcitonin (dose dependently from 10(-8) to 10(-6) M) and increased by 1-34 parathormone (100 ng/ml). None of these hormones induced any modification of the proportion of multinucleated cells formed in adult monocytes culture. Specific antigens on the membrane of the cells obtained after 3 weeks culture in the presence of 10(-9) M 1,25(OH)2D3 were assessed by immunocytochemistry. The respective proportion of adult and cord labeled cells was 64 +/- 11 vs. 63 +/- 6% with Leu M5 (specific for monocyte) and 68 +/- 7 vs. 30 +/- 10% (P less than 0.05) with the anti-HLA DR antibody. The monoclonal antibody 23C6 is specific to the vitronectin receptor, which is highly expressed by osteoclasts--41 +/- 2% of the cells in cord monocyte cultures--but none in the adult monocytes culture were labeled with 23C6 at the end of the culture period.(ABSTRACT TRUNCATED AT 250 WORDS)
Detection and Identification of Fungal Pathogens by PCR and by ITS2 and 5.8S Ribosomal DNA Typing in Ocular Infections (2001)

The goal of this study was to determine whether sequence analysis of internal transcribed spacer/5.8S ribosomal DNA (rDNA) can be used to detect fungal pathogens in patients with ocular infections (endophthalmitis and keratitis). Internal transcribed spacer 1 (ITS1) and ITS2 and 5.8S rDNA were amplified by PCR and seminested PCR to detect fungal DNA. Fifty strains of 12 fungal species (yeasts and molds) were used to test the selected primers and conditions of the PCR. PCR and seminested PCR of this region were carried out to evaluate the sensitivity and specificity of the method. It proved possible to amplify the ITS2/5.8S region of all the fungal strains by this PCR method. All negative controls (human and bacterial DNA) were PCR negative. The sensitivity of the seminested PCR amplification reaction by DNA dilutions was 1 organism per PCR, and the sensitivity by cell dilutions was fewer than 10 organisms per PCR. Intraocular sampling or corneal scraping was undertaken for all patients with suspected infectious endophthalmitis or keratitis (nonherpetic), respectively, between November 1999 and February 2001. PCRs were subsequently performed with 11 ocular samples. The amplified DNA was sequenced, and aligned against sequences in GenBank at the National Institutes of Health. The results were PCR positive for fungal primers for three corneal scrapings, one aqueous sample, and one vitreous sample; one of them was negative by culture. Molecular fungal identification was successful in all cases. Bacterial detection by PCR was positive for three aqueous samples and one vitreous sample; one of these was negative by culture. Amplification of ITS2/5.8S rDNA and molecular typing shows potential as a rapid technique for identifying fungi in ocular samples.
Stability analysis of a boiling loop in low-pressure operation (1977)

The target genes SEC22B, RAB10, and FLT1 may be potential biomarkers of AD.
Analysis of small seismographic station networks (1980)

abstract A procedure is developed for objectively analyzing the geometrical configuration of a small seismographic station network. The elements of the parameter space covariance matrix are used to determine the uncertainty in the hypocentral parameters and their corresponding cross-correlations for a given network geometry. Likewise, the elements of the data space covariance matrix are used to determine which data supply the least information toward the solution of the system of equations and which combinations of observations are redundant. Knowledge of the variation of these covariance matrices in the vicinity of a network allows an objective basis for comparing the performance of proposed network geometrical configurations. A small triangular quadripartite network (10-km radius) is analyzed as an example of the method. For small networks, generally the most important data are S-wave onset times at the peripheral stations and P-wave onset times at the interior stations. The single most useful indicator of the performance of a proposed network configuration is the span of the semi-major axes of the covariance matrices for hypocenters in the vicinity of the network.
A reliable and compact polymer-based package for capacitive RF-MEMS switches (2005)

We present a package for capacitive RF-MEMS switches that is based on laminate substrates and BCB-sealed glass caps. The assembly is realised using standard packaging equipment. The package is only 1.1 mm thick, gross leak tight, has high mechanical strength, and passes accelerated lifetime testing. RF insertion loss was lower than 0.6 dB below 15 GHz. Capacitive switches packaged by the proposed method reach a lifetime of 10/sup 7/ cycles, and sustain 1000 h exposure at 85/spl deg/C/85%RH.
Automated Liver Cell Processing Facilitates Large Scale Isolation and Purification of Porcine Hepatocytes (1995)

An automated method for large scale isolation and purification of porcine hepatocytes is described. Liver cells were harvested by a two-step portal vein perfusion with ethylenediaminetetraacetate and collagenase. Hepatocyte purification was carried out using either a standard manual processing method (Procedure A) or an automated processing method using a filtration chamber and a programmable cell washer (Procedure B). Both methods produced high cell yields (Procedure A: 1.30 +/- 0.55 x 10(10) viable hepatocytes/liver; Procedure B: 1.38 +/- 0.32 x 10(10) viable hepatocytes/liver) and viability (Procedure A: 89 +/- 6.5%; Procedure B: 92 +/- 3.9%). Hepatocyte purity was significantly greater after Procedure B than after Procedure A (93.1 +/- 3.1% versus 83.1 +/- 3%, p < 0.01). Isolated hepatocytes by either method were morphologically intact, as demonstrated by transmission electron microscopy showing integrity of plasma membranes and intracellular organelles. Cultured hepatocytes isolated by either method were functionally intact, although those isolated by Procedure A showed significantly lower activity of microsomal 7-ethoxycoumarin-O-deethylase activity (p < 0.05) and mitochondrial succinate dehydrogenase activity (p < 0.01). In conclusion, use of the automated hepatocyte processing method resulted in efficient large scale preparation of porcine hepatocytes, with higher purity and greater retention of differentiated liver metabolic functions, and was found to be less time consuming and less labor intensive.
Twinning rate in Norwegian cattle: frequency, (co)variance components, and genetic trends. (2000)

The overall twinning rate was shown to increase from .6% in the first parity to 4.0% in the sixth parity, and a positive phenotypic trend for twinning rate was observed during the time period considered (1978 to 1995). The distribution of bulls according to the average percentage of multiple births of daughters in first and second parity showed that some bulls had an extremely low twinning frequency and others exceeded the population mean by approximately six times. (Co)variance components were estimated for twinning in first and second parities using a linear sire model. The analysis included either first- and second-crop daughters (1.4 and .9 million records for first- and second-parity cows, respectively) or first-crop daughters only (.6 and .4 million records for first- and second-parity cows, respectively) from 2,043 sires. Heritability estimates were .7 to .8% in the first parity and 2.8% in the second parity. The genetic correlation between twinning in the first and second parities was approximately 1. Part of the phenotypic trend observed can be explained by a genetic trend for twinning rate.
A Novel Approach to Improving the Mechanical Properties in Recycled Vulcanized Natural Rubber and Its Mechanism (2002)

Vulcanized rubbers have three-dimensional chemical networks, and as a result they do not melt or dissolve. The presence of these networks creates a tremendous problem at the end of a product's life (i.e., recycling). Recently, R. J. Farris et al. have rediscovered a technique coined "high-pressure high-temperature sintering" (HPHTS) that fuses/sinters 100% vulcanized rubber powder into a solid mass recovering approximately 35−40% of the original mechanical properties. A method of enhancing the mechanical properties of sintered natural rubber powder by incorporating various organic compounds will be discussed in this paper. Additives of different chemical structures such as dienophiles (maleic acid and maleic anhydride), dipolarophiles (phthalimide), and organic acids (benzoic acid, salicyclic acid, and others) are employed. Attenuated total reflection infrared spectroscopy (ATR-IR) and electron ionization mass spectrometry (EIMS) are used to investigate the mechanisms of sintering and the underlying factors behind the enhancement of the properties that is seen with incorporation of these additives.
Multiomics profiling of primary lung cancers and distant metastases reveals immunosuppression as a common characteristic of tumor cells with metastatic plasticity (2020)

Metastasis is a molecularly late event, and immunosuppression driven by different molecular events, including somatic copy number aberration, may be a common characteristic of tumors with metastatic plasticity.
Fundamental Analysis of Liquid Atomization by Fuel Slingers in Small Gas Turbines (2002)

Peer Reviewed
Pre-FFT Adaptive Spatial Filter Applied to OFDM Systems (2013)

This paper proposes an adaptive spatial filter scheme in time-domain (pre-FFT), aimed to improve the performance and the capacity of OFDM systems. This strategy uses a supervised adaptive algorithm, with frequency domain multiplexed pilots of the OFDM system as reference. The simplicity of the proposed structure, as well as the method used to obtain reference signals for the adaptive spatial filter are important aspects that distinguish this paper from other publications. Another difference is the discrete characterization of the OFDM system, which resulted in a more appropriate model for the development of this proposal. Details on the operation of the proposed scheme, as well as the BER performance curves, are presented here. The proposal investigated here allows significant reduction in the guard interval of the OFDM system, thereby increasing its robustness or transmission capacity.
Global Media/Local Meaning (1991)

The ineffective impact of an increasingly global media in certain instances due to their lack of a local context and meaning is analysed. It is suggested that the construction of a postmodern brand of cultural 'authenticity' which results in a sense of identification for the viewers is essential for the success of global media in a local context.
Laser cladding of HA/Ti composite coating on NiTi alloy (2013)

To accelerate the bone growth around a metallic implant and to achieve the mechanical characteristics needed for biomedical applications, a hydroxyapatite/pure titanium (HA/Ti) composite coating was produced on NiTi alloy substrate by laser cladding. The experimental results showed that an excellent metallurgical bonding between the coating and the substrate was obtained. Owing to decomposition of HA under irradiation of high power laser, the microstructures of coating were mainly composed of CaO, CaTiO 3 , titanium phosphide and HA phases. In vitro experimental result demonstrated that HA/Ti composite coating made the bioactivity of NiTi alloy improved remarkably while restraining Ni ion from releasing.