gebhart/patrepeval huggingface dataset:
Wavelet based 3D compression with fast random access for very large volume data (2003)

In this paper we propose a wavelet based method for compressing volumetric data with little loss in quality allowing fast random access to individual voxels within the volume. Such a method is important since storing and visualising very large volumes impose heavy demands on internal memory and external storage facilities, a problem not likely to become less in the future, making it accessible only to users with huge and expensive computers. Experimental results on the CT dataset of the Visible Human have shown that our method provides very high compression rates with fairly fast random access.
A Highly Compact Zip Chain Arm with Origami-Inspired Folding Chain Structures (2023)

A deployable robotic arm can be a useful tool for mobile systems to widen accessible areas without removing mobility. For practical use, the deployable robotic arm needs to satisfy two requirements: a high extension-compression ratio and robust structural stiffness against the environment. To this end, this paper suggests, for the first time, an origami-inspired zipper chain to achieve a highly compact, one-degree-of-freedom zipper chain arm. The key component is the foldable chain, which innovatively increases the space-saving capability in the stowed state. The foldable chain is fully flattened in the stowed state, allowing for storage of many more chains in the same space. Moreover, a transmission system was designed to transform a 2D flat pattern into a 3D chain shape in order to control the length of the origami zipper. Additionally, an empirical parametric study was performed to choose design parameters to maximize the bending stiffness. For the feasibility test, a prototype was built and performance tests were executed in relation to extension length, speed, and structural robustness.
Accuracy of Femoral Component Alignment Using Specimen Matched Cutting Blocks: An in Vitro Study (2012)

info:eu-repo/semantics/published
A New Robust Paradigm for Diagnosing Hold-Time Faults in Scan Chains (2006)

Hold-time violation is a common cause of failure at scan chains. A robust new paradigm for diagnosing such failure is presented in this paper. As compared to previous methods, the major advantage of ours is the ability to tolerate non-ideal conditions, e.g., under the presence of certain core logic faults or for those faults that manifest themselves intermittently. We first formulate the diagnosis problem as a delay insertion process. Then, two algorithms including a greedy algorithm and a so-called best-alignment based algorithm are proposed. Experimental results on a number of real designs are presented to demonstrate its effectiveness
CT-based virtual shape reconstruction for severe glenoid bone defects (2011)

status: Published
Rhizospheric Mobilization of Radiocesium in Soils (2000)

Though soil−plant transfer is the first step by which radiocesium enters the food chain, it has been scarcely studied in the rhizosphere. Forty-seven soil horizons from 17 pedons with widely varying properties were contaminated with carrier-free 137Cs+ and placed into close contact with an active macroscopic rhizosphere of ryegrass for 4 days. The 137Cs rhizospheric mobilization was strongly correlated with the sodium tetraphenylboron-extractable 137Cs (r = 0.94), supporting that K depletion in the rhizosphere is a capital driving force in 137Cs uptake. The 137Cs soil−plant transfer factor varied from 0.02 to 3.69 g g-1 between soil materials and was strongly negatively correlated to the radiocesium interception potential (RIP) (r = −0.88), a common Cs binding characteristic in soil. RIP largely differed between soil materials (13−4861 μmol g-1) and was directly related with the soil vermiculite content (r = 0.70). Our results, validated in a wide variety of soils, show that both vermiculitic minerals and plant roots act as competitive sinks for 137Cs+ in the rhizosphere. They further support that many 137Cs-polluted soils in semi-natural environments can act as a potential source for long-term contamination of the above standing vegetation because they have low K availability.
Assessment of conservative load transfer for fluid-solid interface with non-matching meshes (2005)

We present a detailed comparative study of three conservative schemes used to transfer interface loads in fluid–solid interaction simulations involving non-matching meshes. The three load transfer schemes investigated are the node-projection scheme, the quadrature-projection scheme and the common-refinement based scheme. The accuracy associated with these schemes is assessed with the aid of 2-D fluid–solid interaction problems of increasing complexity. This includes a static load transfer and three transient problems, namely, elastic piston, superseismic shock and flexible inhibitor involving large deformations. We show how the load transfer schemes may affect the accuracy of the solutions along the fluid–solid interface and in the fluid and solid domains. We introduce a grid mismatching function which correlates well with the errors of the traditional load transfer schemes. We also compare the computational costs of these load transfer schemes. Copyright © 2005 John Wiley & Sons, Ltd.
High-risk human papillomavirus viral load and persistence among heterosexual HIV-negative and HIV-positive men (2014)

HR-HPV genotypes with high viral load are more likely to persist among HIV-negative and HIV-positive men, though persistence was more common among HIV-positive men overall. The results may explain the association between high HR-HPV viral load and HR-HPV transmission.
Smarter innovation process for the enablement of a smarter planet (2010)

The recent IBM initiative of a "Smarter Planet" can be netted out with three big ideas:
Unscheduled bleeding during initiation of continuous combined hormone replacement therapy: a direct comparison of two combinations of norethindrone acetate and ethinyl estradiol to medroxyprogesterone acetate and conjugated equine estrogens (2001)

The results indicate that statistically significantly more women attained amenorrhea based on various parameters when administered continuous combined NA/EE compared with CEE/MPA. The potential for long-term treatment compliance based on better bleeding control may optimize the opportunity to prevent osteoporosis as well as other associated health benefits.
Repression of Oct4 expression by the orphan nuclear receptor GCNF requires recruitment of MBD3 to the promoter (2006)

ES cell self renewal is maintained by a core of key transcription factors that include Oct4, Sox2 and Nanog that through feed forward and feed back mechanisms maintain pluripotence gene expression. However, specific mechanisms are required to disrupt this novel pattern of gene expression upon differentiation. Upon differentiation of ES cells Oct4 gene expression is repressed and subsequently silenced. Nuclear receptors are critical for regulation of pluripotence gene expression during embryonic stem cell differentiation and embryonic development. The orphan nuclear receptor GCNF has been shown to play a central role in the repression of Oct4 by binding to a response element in its promoter. Efforts to characterize mediators of GCNF’s repressive function on the Oct4 promoter identified Methyl DNA binding protein, MBD3, as a GCNF interacting factor. The ligand binding domain of GCNF interacts with methyl DNA binding domain of MBD3. In P19 and ES cells, upon differentiation endogenous GCNF binds to the Oct4 proximal promoter and recruits MBD3, in a RA dependent manner. In RA‐differentiated GCNF −/− ES cells recruitment of MBD3 is lost and subsequently repression of Oct4 expression fails to occur. RNAi mediated knock‐down of MBD3 expression results in reduced Oct4 repression in differentiated P19 cells. Thus, we have shown that GCNF recruits MBD3 to the Oct4 promoter to mediate repression of Oct4 gene expression during differentiation of P19 and ES cells. The direct interaction between GCNF and MBD3 provides specificity of recruitment for a relatively non‐specific DNA binding factor. Thus, MBD3 is a novel nuclear receptor co‐repressor that is required to repress pluripotency gene expression upon ES cell differentiation.
Clinician Satisfaction with Rapid Adoption and Implementation of Telehealth Services During the COVID-19 Pandemic (2021)

<b>Background:</b> To examine clinician perspectives on the acceptability, appropriateness/suitability, and feasibility of video telehealth as a way to deliver mental health services during the COVID-19 pandemic. <b>Materials and Methods:</b> Mental health clinicians were surveyed with 27 Likert questions, using previously validated measures, on satisfaction and implementation experience with video telehealth visits between March and June 2020. <b>Results:</b> A total of 112 of 193 clinicians completed the survey (58.0%), including psychiatrists, psychologists, trainees (i.e., residents and fellows), advanced practice providers, and licensed mental health counselors. Clinicians reported high levels of acceptability, feasibility, and appropriateness of video telehealth; they also reported high levels of satisfaction with video telehealth visits. Seventy-nine and a half (79.5%) reported that their patients seemed highly satisfied with video telehealth visits, and 107 (95.5%) of clinicians responded that they would like video telehealth visits to represent at least 25% of their practice in the future. <b>Discussion:</b> Mental health clinicians showed positive attitudes toward the implementation of video telehealth visits, high levels of satisfaction with this care, and indicated strong interest in continuing this modality as a significant portion of clinical practice. <b>Conclusions:</b> This study demonstrates the ability of mental health clinicians to embrace new technology to expand access to care during the COVID-19 pandemic. Results indicate that telemental health is likely to be an integral part of clinic practice in the future.
Local ex vivo gene therapy with bone marrow stromal cells expressing human BMP4 promotes endosteal bone formation in mice (2004)

The present findings support the feasibility of using ex vivo MSC-based retroviral gene therapy to induce relatively sustained new bone formation, with normal histological appearance, at endosteal bone sites.
Pteridine analogues; synthesis and physico‐chemical properties of 7‐oxopyrazino[2,3‐c][1,2,6]thiadiazine 2,2‐dioxides (1988)

Abstract Condensation of diaminothiadiazine 1,1‐dioxides 1 or 8 with α‐keto acid esters affords 7‐oxopyrazino[2,3‐ c ][1,2,6]thiadiazine 2,2‐dioxides 2–4 and 9 . Further chemical transformations yield 6‐substituted derivatives. The structures of the newly synthesized compounds are discussed on the basis of 1 H‐ and 13 C‐NMR data, UV spectra and p K α values.
A New Class of Extended Tetrathiafulvalene Cruciform Molecules for Molecular Electronics with Dithiafulvene‐4,5‐Dithiolate Anchoring Groups (2012)

Cruciform motifs with two orthogonally oriented π-extended tetrathiafulvalenes and with differently protected thiolate end-groups are synthesized by stepwise coupling reactions. The molecules are subjected to single-molecule conductivity studies in a break-junction and to conducting probe atomic force microscopy studies in a self-assembled monolayer on gold.
Development of a Solid Chlorate Backup Oxygen Delivery System for the International Space Station (2000)

The International Space Station (ISS) Program requires that there always be a 45 calendar day contingency supply of breathing oxygen. In the early assembly stages, there is only one flight system, the Russian Solid Fuel Oxygen Generator (SFOG), that can meet that requirement. To better ensure the contingency oxygen supply, the Crew and Thermal Systems Division was directed to develop a flight hardware system that can meet all contingency oxygen requirements for ISS. Such a system, called the Backup Oxygen Candle System (BOCS), has been built and tested. The BOCS consists of 33 chlorate candles, a thermal containment apparatus, support equipment and packaging. The thermal containment apparatus utilizes the O2 produced by the candle as the motive stream in an ejector to passively cool the candle during operation.
Faculty Opinions recommendation of Impact of prenatal maternal cytokine exposure on sex differences in brain circuitry regulating stress in offspring 45 years later. (2021)

Stress is associated with numerous chronic diseases, beginning in fetal development with in utero exposures (prenatal stress) impacting offspring's risk for disorders later in life. In previous studies, we demonstrated adverse maternal in utero immune activity on sex differences in offspring neurodevelopment at age seven and adult risk for major depression and psychoses. Here, we hypothesized that in utero exposure to maternal proinflammatory cytokines has sex-dependent effects on specific brain circuitry regulating stress and immune function in the offspring that are retained across the lifespan. Using a unique prenatal cohort, we tested this hypothesis in 80 adult offspring, equally divided by sex, followed from in utero development to midlife. Functional MRI results showed that exposure to proinflammatory cytokines in utero was significantly associated with sex differences in brain activity and connectivity during response to negative stressful stimuli 45 y later. Lower maternal TNF-α levels were significantly associated with higher hypothalamic activity in both sexes and higher functional connectivity between hypothalamus and anterior cingulate only in men. Higher prenatal levels of IL-6 were significantly associated with higher hippocampal activity in women alone. When examined in relation to the anti-inflammatory effects of IL-10, the ratio TNF-α:IL-10 was associated with sex-dependent effects on hippocampal activity and functional connectivity with the hypothalamus. Collectively, results suggested that adverse levels of maternal in utero proinflammatory cytokines and the balance of pro- to anti-inflammatory cytokines impact brain development of offspring in a sexually dimorphic manner that persists across the lifespan. PMID: 33876747
Components of strong magnetoresistance in Mn implanted Ge (2014)

Strong magnetoresistance reaching thousands of percent and non-monotonic field dependent Hall effect were measured in Mn implanted Ge samples in fields up to 60 T and analyzed in the framework of a two carriers model. The measured Hall effect and temperature dependent zero field resistance can be consistently described by parallel conductance along thick p-type Ge substrate with low concentration of highly mobile carriers and along thin Mn doped Ge layer with low mobility carriers. However, the same model is not sufficient to explain experimentally observed suppression of quadratic field dependence of magnetoresistance at low fields and absence of its saturation at high fields. Two additional mechanisms were identified: a strong quasi-linear magnetoresistance of Ge substrate that dominates the low field range and a non-saturating “3/2” power law magnetoresistance of the Mn doped Ge layer dominating the high field range.
Novel sensors for monitoring acoustic cavitation (2002)

This paper describes a novel acoustic sensor of potential application in monitoring cavitation occurring within ultrasonic cleaning vessels. The sensors, fabricated in the form of hollow cylinders, are manufactured from a thin (110 /spl mu/m) piezoelectric polymer whose acoustic bandwidth (10 MHz) is sufficient to detect the high-frequency signals generated by cavitating bubble collapse. One of the key characteristics of the sensors is their spatial resolution: acoustic signals detected at high frequencies originate from bubble events occurring within the hollow cylinder itself. To isolate these, the cavitation sensors are encapsulated in a 4 mm thick layer of a specially-developed acoustical absorber acting as a shield to bubble events occurring outside of the sensor volume. The construction of the new sensor is described, and early results of its response in the acoustic field of an ultrasonic cleaning vessel are presented.
Coupled High Performance Liquid Chromatography with High Resolution Gas Chromatography (2001)

This chapter contains sections titled: Introduction Transfer Techniques Vaporization with Hot Injectors Transfer of Water-Containing Solvent Mixtures Indirect Introduction of Water Conclusions
Implication of an Outer Surface Lipoprotein in Adhesion of Bifidobacterium bifidum to Caco-2 Cells (2008)

We found that the human intestinal isolate Bifidobacterium bifidum MIMBb75 strongly adhered to Caco-2 cells. Proteinase K and lithium chloride treatments showed that proteins play a key role in MIMBb75 adhesion to Caco-2 cells. By studying the cell wall-associated proteins, we identified a surface protein, which we labeled BopA. We purified the protein chromatographically and found that it functioned as an adhesion promoter on Caco-2 cells. In silico analysis of the gene coding for this protein and globomycin experiments showed that BopA is a cysteine-anchored lipoprotein expressed as a precursor polypeptide. A database search indicated that BopA appears to function biologically as an oligopeptide/tripeptide-solute-binding protein in the ABC transport system. We discovered a protein corresponding to BopA and its gene in eight other highly adherent B. bifidum strains. Finally, we found that B. bifidum MIMBb75 and BopA affected the production of interleukin-8 in Caco-2 epithelial cells. BopA is the first protein described to date to be directly involved in the adhesion of bifidobacteria to Caco-2 cells and to show immunomodulatory activity.
Changes in materials properties explain the effects of humidity on gecko adhesion (2010)

Geckos owe their remarkable stickiness to millions of dry setae on their toes, and the mechanism of adhesion in gecko setae has been the topic of scientific scrutiny for over two centuries. Previously, we demonstrated that van der Waals forces are sufficient for strong adhesion and friction in gecko setae, and that water-based capillary adhesion is not required. However, recent studies demonstrated that adhesion increases with relative humidity (RH) and proposed that surface hydration and capillary water bridge formation is important or even necessary. In this study, we confirmed a significant effect of RH on gecko adhesion, but rejected the capillary adhesion hypothesis. While contact forces of isolated tokay gecko setal arrays increased with humidity, the increase was similar on hydrophobic and hydrophilic surfaces, inconsistent with a capillary mechanism. Contact forces increased with RH even at high shear rates, where capillary bridge formation is too slow to affect adhesion. How then can a humidity-related increase in adhesion and friction be explained? The effect of RH on the mechanical properties of setal β-keratin has escaped consideration until now. We discovered that an increase in RH softens setae and increases viscoelastic damping, which increases adhesion. Changes in setal materials properties, not capillary forces, fully explain humidity-enhanced adhesion, and van der Waals forces remain the only empirically supported mechanism of adhesion in geckos.
Supplementary Figure from Tumor Genomic Testing for >4,000 Men with Metastatic Castration-resistant Prostate Cancer in the Phase III Trial PROfound (Olaparib) (2023)

Supplementary Figure from Tumor Genomic Testing for &gt;4,000 Men with Metastatic Castration-resistant Prostate Cancer in the Phase III Trial PROfound (Olaparib)
Ruling out Pulmonary Embolism in Patients with High Pretest Probability (2018)

Our analysis suggests that in patients with high PTP of PE, neither negative CTPA by itself nor a negative CTPA <i>plus a</i> negative D-dimer are sufficient to rule out PE. More aggressive workup strategies may be required for these patients.
Expression of multiple angiogenic cytokines in cultured normal human prostate epithelial cells: Predominance of vascular endothelial growth factor (1999)

The cytokines that regulate angiogenesis in normal and malignant prostate tissue are not well studied. Using an RT-PCR-based screen, we observed that cultured, low-passage normal human prostate epithelial cells (PrECs) express a variety of cytokines which have been shown to have angiogenic and/or endothelial cell-activating properties in various systems. These include vascular endothelial growth factor (VEGF), basic fibroblastic growth factor (bFGF), transforming growth factor-alpha (TGF-alpha), transforming growth factor-beta (TGF-beta), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-alpha), granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF). Expression of VEGF, bFGF, GM-CSF, G-CSF, TGF-alpha and TNF-alpha in these cells was confirmed by immunohistochemistry. Culture medium conditioned by normal human PrECs for periods of up to 96 hr were found to contain VEGF, GM-CSF, G-CSF, IL-8, TGF-beta1 and TGF-beta2 but not TNF-alpha or bFGF, as determined by ELISA. Of these, VEGF was by far the most prominently expressed angiogenic cytokine (approx. 2,500 pg/ml conditioned medium at 96 hr vs. 30 to 100 pg/ml conditioned medium for the other cytokines). PrEC-conditioned medium induced an approximately 2-fold stimulation of [3H]-thymidine incorporation in cultured human umbilical cord endothelial cells (HUVECs) deprived of the endothelial growth factors VEGF and bFGF; this stimulation was abolished by neutralizing antibodies directed against VEGF but not bFGF, IL-8, GM-CSF or TNF-alpha. VEGF expression by PrECs was not markedly altered by administration or deprivation of other angiogenic cytokines for which these cells have receptors, suggesting that there is not a hierarchy of cytokines controlling its expression; however, retinoic acid, a component of PrEC growth medium, was found to modestly suppress VEGF at physiological concentrations (0.1 ng/ml). These data suggest that normal PrECs express a variety of angiogenic cytokines, most prominently VEGF, to recruit a supporting vasculature, even in culture. Our data also suggest that the ability of malignant PrECs to stimulate angiogenesis may be intrinsic and does not need to be acquired during oncogenesis.
ChemInform Abstract: Homobimetallic Ruthenium‐N‐heterocyclic Carbene Complexes for Olefin Metathesis (2010)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Heart-type fatty acid-binding protein in the early diagnosis of acute myocardial infarction: a systematic review and meta-analysis (2011)

<h3>Abstract</h3> In synthetic biology, biosensors are routinely coupled to a gene expression cascade for detecting small molecules and physical signals. We posit that an alternative direct protein (DiPro) biosensor mechanism, could provide a new opportunity for rapid detection of specific chemicals. Herein, we reveal a fluorescent curcumin DiPro biosensor, based on the <i>Escherichia</i> coli double bond reductase (<i>Ec</i>CurA) as a detection system. We characterise the <i>Ec</i>CurA DiPro biosensor and propose enhanced curcumin fluorescence is generated through π-π stacking between protein and ligand. Using a cell-free synthetic biology approach, we use the <i>Ec</i>CurA DiPro biosensor to fine tune 10 reaction parameters (cofactor, substrate, and enzyme levels) for cell-free biosynthesis, assisted through acoustic liquid handling robotics. Overall, we increase <i>Ec</i>CurA-curcumin fluorescence by 80-fold. We speculate that a generic DiPro biosensor fluorescence mechanism can be further exploited for a wider range of chemicals that share intrinsic fluorescence and have a suitable binding protein.
Table S9 from Characterizing the immune microenvironment and neoantigen landscape of Hürthle cell carcinoma to identify potential immunologic vulnerabilities (2023)

&lt;p&gt;Neopeptides (10mer) associated with INDELS in HCC&lt;/p&gt;