gebhart/patrepeval huggingface dataset:
Katı yüzeylere özgül bağlanan peptidlerin moleküler karakterizasyonu (2011)

Anorganik yuzeyler cesitli kimyasal gruplar kullanilarak fonksiyonel hale getirilmektedirler. Bu molekullerin yuzeylerde olusturduklari kendiliginden orgutlenen yapilar ile yuzeylere istenilen fonksiyonellik kazandirilmaktadir. Ancak, kullanilan kimyasal molekuler baglayicilar tek bir yuzeye ozgul olmamakta,birden fazla yuzeye afinite gostermektedirler. Coklu malzeme iceren yuzeylerde kimyasal baglayicilarla asilamayan bu durum, son yillarda kombinatoryel biyoloji yontemleri ile yeni nesil peptid molekuler baglayicilar kullanilarak asilmaya calisilmaktadir. Yonlendirilmis evrim yolu ile faj gosterim ve hucre yuzey gosterim teknikleri kullanilarak farkli malzeme yuzeylerine ozgul olan peptitlerin molekuler baglayicilar olarak kullanimi biyo-nanoteknolojik calismalarda artan oranda ilgi toplanmaktadir. Bu calisma kapsaminda altin, platin ve silika yuzeylerine ozgul olarak secilmis peptidlerin, adsorpsiyon kinetik parametreleri, peptidlerin yapisal ozellilklerine bagli olarak incelenmistir. Bu calisma dahilinde peptidlerin anorganik yuzeylerle etkilesimleri yuzey plazmon spektrometresi ile incelenmistir. Deneylerde, peptidlerin ilk secilmis dizileri ile coklu tekrarlarindan olusmus diziler kullanilmistir. Calisma sonucunda platine ozgul PtBP2, silikaya ozgul baglanan QBP1 ve altina ozgul baglanan GBP, molekullerinde bu peptidlerin orijinal aminaasit dizilerinin uclu tekrarlarinin yuzeylerde kaplama yuzdesini artirdigi gorulmustur. Ancak platine ozgul PtBP1 ve silikaya ozgul QBP2 peptidlerinde ayni durum gozlenememistir. Bu calisma sonucunda anorganik yuzeylere ozgul peptidlerin gostermis olduklari yuksek yuzey kaplama oranlari sayesinde, kati yuzeylerin islevsellestirilmesi icin iyi birer molekuler baglayici olduklari saptanmistir. Anahtar Kelimeler: Peptidler, yuzey islevselligi, molekuler tanima , biyo-nanoteknoloji.
Spatio-Temporal Distribution of Acinetobacter baumannii in Germany—A Comprehensive Systematic Review of Studies on Resistance Development in Humans (2000–2018) (2020)

<i>Acinetobacter</i> (<i>A.</i>) <i>baumannii</i> has gained global notoriety as a significant nosocomial pathogen because it is frequently associated with multi-drug resistance and hospital-based outbreaks. There is a substantial difference in the incidence of <i>A. baumannii</i> infections between different countries and within Germany. However, its continuous spread within Germany is a matter of concern. A systematic literature search and analysis of the literature published between 2000 and 2018 on <i>A. baumannii</i> in humans was performed. Forty-four studies out of 216 articles met the criteria for inclusion, and were selected and reviewed. The number of published articles is increasing over time gradually. Case reports and outbreak investigations are representing the main body of publications. North Rhine-Westphalia, Hesse and Baden-Wuerttemberg were states with frequent reports. Hospitals in Cologne and Frankfurt were often mentioned as specialized institutions. Multiresistant strains carrying diverse resistance genes were isolated in 13 of the 16 German states. The oxacillinase <i>bla</i>OXA-23-like, intrinsic <i>bla</i>OXA-51-like, <i>bla</i>OXA-58 variant, <i>bla</i>NDM-1, <i>bla</i>GES-11, <i>bla</i>CTX-M and <i>bla</i>TEM are the most predominant resistance traits found in German <i>A. baum</i>annii isolates. Five clonal lineages IC-2, IC-7, IC-1, IC-4 and IC-6 and six sequence types ST22, ST53, ST195, ST218, ST944/ST78 and ST348/ST2 have been reported. Due to multidrug resistance, colistin, tigecycline, aminoglycosides, fosfomycin, ceftazidime/avibactam and ceftolozan/tazobactam were often reported to be the only effective antibiotics left to treat quadruple multi-resistant Gram-negative (4MRGN) <i>A. baumannii.</i> Dissemination and infection rates of <i>A. baumannii</i> are on the rise nationwide. Hence, several aspects of resistance development and pathogenesis are not fully understood yet. Increased awareness, extensive study of mechanisms of resistance and development of alternative strategies for treatment are required. One-Health genomic surveillance is needed to understand the dynamics of spread, to identify the main reservoirs and routes of transmission and to develop targeted intervention strategies.
High-throughput fabrication of right-angle prism mirrors with selective metalization by two-step 3D printing and computer vision alignment (2020)

We propose a dual step µ-3D printing (two-photon lithography) strategy, which is the 3D version of the classic lithography etching-mask strategy, to achieve selective gold metallization for the realization of reflective micro-optics. We apply this strategy to obtain right-angle prism micro-mirrors used to create dynamic counterpropagating optical traps for biological samples in a holographic optical trapping setup with a single low-NA objective. We print the prisms on standard glass coverslips to create integrated optical trapping chips. We show the automatization of alignment between prisms and masks by a computer vision software.
Olefins can limit desulfurization of reformer feedstock (1995)

Pilot plant studies have shown that the presence of even very small amounts of olefins may limit the desulfurization of reformer feedstocks to trace levels. Engineers at the Research Institute of King Fahd University of Petroleum and Minerals observed under typical industrial conditions the recombination reaction of olefins with hydrogen sulfide to form mercaptans. The results indicate that the advantage of using highly active (third generation) CoMo hydrotreating catalysts can be masked by these reactions if the olefins are not saturated. The trend in naphtha reforming is to use high-rhenium, bimetallic catalysts that display less resistance to sulfur than do balanced Pt-Re catalysts. Due consideration, therefore, should be given to these undesirable recombination reactions while designing hydrotreaters and selecting hydrodesulfurization (HDS) and reforming catalysts. The paper discusses catalysts and feedstock tests, catalyst activity, temperature effects, space velocity, feedstock effect, catalyst performance, and recommendations.
Accelerator Memory Reuse in the Dark Silicon Era (2012)

Accelerators integrated on-die with General-Purpose CPUs (GP-CPUs) can yield significant performance and power improvements. Their extensive use, however, is ultimately limited by their area overhead; due to their high degree of specialization, the opportunity cost of investing die real estate on accelerators can become prohibitive, especially for general-purpose architectures. In this paper we present a novel technique aimed at mitigating this opportunity cost by allowing GP-CPU cores to reuse accelerator memory as a non-uniform cache architecture (NUCA) substrate. On a system with a last level-2 cache of 128kB, our technique achieves on average a 25% performance improvement when reusing four 512 kB accelerator memory blocks to form a level-3 cache. Making these blocks reusable as NUCA slices incurs on average in a 1.89% area overhead with respect to equally-sized ad hoc cache slices.
Sustained and rapid virological responses in hepatitis C clinical trials (2013)

Direct-acting antivirals (DAAs) in combination with pegylated IFN-a and ribavirin drastically improve the rates of rapid virological response (RVR) and sustained virological response (SVR) in the treatment of chronic hepatitis C virus infection, specifically in difficult-to-cure hepatitis C virus genotype 1. At present, RVR is an important milestone highly predictive of SVR. Response-guided therapy based on RVR is important to shorten the treatment duration whilst preserving the greatly improved SVR rate, given that DAA-based treatments are costly and could produce serious adverse events and antiviral-resistant variants. Because strong factors other than RVR independently influence SVR, more highly personalized treatments should be developed through a combination of several robust factors. The advent of more potent DAAs may change the concept of RVR and SVR.
A charge-switchable, four-armed polymeric photosensitizer for photodynamic cancer therapy (2014)

A water-soluble, charge-switchable, four-armed polymeric photosensitizer (C4P-PS), in which charge switching is pH dependent, has been designed as a new class of photosensitizer for photodynamic cancer therapy.
Gas Sensing Interfaces Of Solid Electrolyte Based Carbon Dioxide Sensors Attached With Metal Carbonate (2005)

SUMMARY The solid electrolyte CO2 sensor which combines a NASICON based electrochemical cell with a metal carbonate auxiliary phase is shown to have two gas-sensitive interfaces, i.e., NASICON/sensing electrode (02-sensitive) and carbonatehensing electrode (CO2-sensitive). The latter interface dominates EMF of the device in the high temperature region, providing the device with CO2 sensing capability. In the lower temperature region the former interface dominates, resulting in a complete loss of CO2 sensitivity. The use of a binary carbonate auxiliary phase can effectively extend the lower temperature limit for CO;! sensing operation.
A Highly Stereoselective Synthesis of 2-Deoxy-β-glycosides Using 2-Deoxy-2-iodo-glucopyranosyl Acetate Donors (1999)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTA Highly Stereoselective Synthesis of 2-Deoxy-β-glycosides Using 2-Deoxy-2-iodo-glucopyranosyl Acetate DonorsWilliam R. Roush and Chad E. BennettView Author Information Department of Chemistry, University of Michigan Ann Arbor, Michigan 48109 Department of Chemistry, Indiana University Bloomington, Indiana 47405 Cite this: J. Am. Chem. Soc. 1999, 121, 14, 3541–3542Publication Date (Web):March 26, 1999Publication History Received18 December 1998Published online26 March 1999Published inissue 1 April 1999https://pubs.acs.org/doi/10.1021/ja984365jhttps://doi.org/10.1021/ja984365jrapid-communicationACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views1488Altmetric-Citations123LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Analytical apparatus,Chemical reactions,Ethers,Organic compounds,Substituents Get e-Alerts
Analysis of the genome of the five Bifidobacterium breve strains: plasmid content, pulsed-field gel electrophoresis genome size estimation and rrn loci number (1993)

The genomes of the five Bifidobacterium breve strains available from culture collections were compared by restriction endonuclease analysis. Electrophoretic migration of undigested DNA allowed us to detect a 5.6-kb circular plasmid in two of these strains. A restriction map of this plasmid was constructed using 10 enzymes. With DraI endonuclease, pulsed-field gel electrophoresis has allowed the determination of the five B. breve genome sizes to 2.1 Mb. This estimation was further confirmed for CIP 6469 (type strain) and ATCC 15698 using XbaI and SpeI enzymes. In addition, rRNA gene regions were used as probes for strain characterization and suggest that there are at least three rrn loci in B. breve.
Sensors simulation environment for sensor data fusion (2011)

There are efforts in the wide field of applications today to fuse heterogeneous data from sensors in order to provide outputs, which are more informative than the original data from particular sensors. Reliable data are essential to be able to fuse sensor data in sensor fusion system. Nevertheless, it is in some cases difficult or even impossible to build a real environment complete with deployed sensors in order to ensure reliable data for the research, development and testing of sensor data fusion systems. Implementation of a sensors simulation environment, which would generate synthetic sensor data (numerical and non-numerical) is a solution to fulfill such efforts. This article describes a proposal of open source technologies, components, interfaces and architecture of a sensors simulation environment, which is able to generate synthetic sensors data according to user-defined scenarios. The defined and described architecture allows standardized interconnection of sensor simulators with fusion systems within a communication net.
Azobenzene as Photoresponsive Conformational Switch in Cyclic Peptides (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Diversity-Enabled and Power-Efficient Transceiver Designs for Peak-Power-Limited SIMO-OFDM Systems (2010)

Orthogonal frequency division multiplexing (OFDM) has been widely adopted for high data rate wireless transmissions. By deploying multiple receiving antennas, single-input multiple-output- (SIMO-) OFDM can further enhance the performance with spatial diversity. However, due to the large dynamic range of OFDM signals and the nonlinear nature of analog components, it is pragmatic to model the transmitter with a peak-power constraint. A natural question to ask is whether SIMO-OFDM transmissions can still enjoy the antenna diversity in this case. In this paper, the effect of the peak-power limit on the error performance of uncoded SIMO-OFDM systems is studied. In the case that the receiver has no information about the transmitter nonlinearity, we show that full antenna diversity can still be collected by carefully designing the transmitters, while the receiver performs a maximum ratio combining (MRC) method which is implemented the same as that in the average power constrained case. On the other hand, when the receiver has perfect knowledge of the peak-power-limited transmitter nonlinearity, zero-forcing (ZF) equalizer is able to collect full antenna diversity. In addition, an iterative method on joint MRC and clipping mitigation is proposed to achieve high performance with low complexity.
Propionibacteria flora in Swiss raw milk from lowlands and Alps (1999)

The propionic acid bacterial tlora in Swiss raw milk was investigated. Four hundred and fifty-three strains from lowland milk and 21 strains from Alpine raw milk were c1assified to the species level by protein profile analysis and restriction analysis of the 23S ribosomal ribonucleic acid (rRNA). Plasmid profiles and random amplified polymorphie deoxyribonucleic acid (RAPD) was used to differentiate the strains. The tlora was found to be extremely diverse. Ali four dairy Propionibacterium species were found in lowland raw milk: 71 % were P.freudenreichii, 19 % P.jensenii, 8 % P. acidipropionici and 2 % P. thoenii. P. acidipropionici was not found in alpine milk but P. freudenreichii made up 55 %, P. jensenii 15 % and P. thoenii 30 % of the total. Among 278 P.freudenreichii strains, 219 (79 %) different strains were identified by RAPD to the strain level. For the other species strain diversity was even greater. Only 30 % of the strains analyzed carried plasmids. The Swiss chee se industry has a large reservoir of Propionibacterium strains in raw milk for future applications and developments.
Room Temperature Laser Action of Y2SiO5:Cr4+ Crystal (2004)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text A. G. Avanesov, V. A. Lebedev, B. I. Denket, B. I. Galagan, V. V. Osiko, S. E. Sverchkov, and A. V. Shestakov, "Room Temperature Laser Action of Y2SiO5:Cr4+ Crystal," in Advanced Solid State Lasers, T. Fan and B. Chai, eds., Vol. 20 of OSA Proceedings Series (Optica Publishing Group, 1994), paper TL2. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Highly Stable and Efficient Perovskite Solar Cells with 22.0% Efficiency Based on Inorganic–Organic Dopant‐Free Double Hole Transporting Layers (2020)

Abstract Most of the high performance in perovskite solar cells (PSCs) have only been achieved with two organic hole transporting materials: 2,2′,7,7′‐tetrakis( N , N ‐di‐ p ‐methoxyphenylamine)‐9,9‐spirobifluorene (Spiro‐OMeTAD) and poly(triarylamine) (PTAA), but their high cost and low stability caused by the hygroscopic dopant greatly hinder the commercialization of PSCs. One effective alternative to address this problem is to utilize inexpensive inorganic hole transporting layer (i‐HTL), but obtaining high efficiency via i‐HTLs has remained a challenge. Herein, a well‐designed inorganic–organic double HTL is constructed by introducing an ultrathin polymer layer dithiophene‐benzene (DTB) between CuSCN and Au contact. This strategy not only enhances the hole extraction efficiency through the formation of cascaded energy levels, but also prevents the degradation of CuSCN caused by the reaction between CuSCN and Au electrode. Furthermore, the CuSCN layer also promotes the formation of a pinhole‐free and compact DTB over layer in the CuSCN/DTB structure. Consequently, the PSCs fabricated with this CuSCN/DTB layer achieves the power conversion efficiency of 22.0% (certified: 21.7%), which is among the top efficiencies for PSCs based on dopant‐free HTLs. Moreover, the fabricated PSCs exhibit high light stability under more than 1000 h of light illumination and excellent environmental stability at high temperature (85 °C) or high relative humidity (&gt;60% RH).
324 A basic study on precision cutting of free form using diamond abrasive wire (2006)

Recently, many cut off processes are research and development. In the production process such as the silicon wafer or the crystal resonator, the multi-wire saw is often used. But, the cut off in free form is difficult by this method. In the case of free form cutting, wire EDM, laser cutting and waterjet machining are properly used by work material and work thickness, etc. In other words, the wire EDM is not adapted for non-conducting material, and it is difficult by the laser cutting and the waterjet machining that the thick workpiece is cut off with thin cutting width. So, the author proposes free form cut off method using diamond abrasive wire for non-conductive material such as optical glass. In this research, concept of proposal method and development of cut off unit for initial experiment are reported.
Biological Control (2021)

It is increasingly becoming apparent that efficient, productive, and sustainable agriculture comes at a cost to the environment. Indiscriminate use of pesticides for control of insect pests, plant pathogens, weeds, and nematodes is no longer permissible due to risk of environmental and health hazards to human beings, animals, and other beneficial insects. There is now awareness and pressing need to look beyond chemical means of managing these biotic stresses. It is thus inevitable that biological control (BC) strategies can fill up the vacuum in the control measures. Past few decades have witnessed tremendous breakthrough and increasing interest and research efforts on BC of insects, pathogens, and nematodes in many countries across the world. This chapter aims at discussing a suggested strategy for more efficient conservation BC under climate change.
Comparative analysis of melanin deposition between Chishui silky fowl and Taihe silky fowl (2021)

Melanin is the key functional ingredient of silky fowl that has nutritional and medicinal benefits. Chishui silky fowl has unique black feather, black skin, green shell egg and black claws, while the melanin deposition of main tissues in the Chishui silky fowl remains unknown. This study aimed to investigate the pigmentation in four tissues of Chishui silky fowls compared with Taihe silky fowl from the lightness value of different tissues black degree, melanin content and the mRNA expression levels of pigmentation related genes such as ASIP, MC1R, MITF, TYR and TYRP1 by using colorimeter, enzymatic hydrolysis and RT–PCR, respectively. The results revealed that the lightness values of the chest muscle and liver, and the melanin content of leg muscle in the Taihe silky fowl were significantly higher than Chishui silky fowl hens (P < 0.05). Compared with Chishui silky fowl, the mRNA expression levels of MITF, TYR and TYRP1 were significantly upregulated in the skin of Taihe silky fowl (P < 0.05). In conclusion, the comparative analysis from lightness value, melanin content and mRNA expression levels of pigmentation-related genes indicated that Chishui silky fowl has equivalent pigmentation in the skin, muscles (chest and leg) and liver compared with Taihe silky fowl.
The important predictors of cycling use in three groups of knee patients (2011)

Age and sex, and not the clinical diagnosis, are the predictors of the ability of a patient to cycle. An increased BMI is the only risk factor found for experiencing pain while cycling.
Anisotropic Fluorescence Emission and Photobleaching at the Surface of One-Dimensional Photonic Crystals Sustaining Bloch Surface Waves. II. Experiments (2019)

Photonic crystal (PC)-enhanced fluorescence has been proposed as a novel tool for early disease detection in liquid biopsy. Photobleaching of the emitters has never been deeply investigated, although its cross section is expected to increase because of the large field intensity enhancement in PC. Herein, we report on the experimental investigation of the anisotropic effects arising when fluorescence excitation and emission are coupled to differently polarized modes of the same PC structure. In particular, we experimentally characterized the anisotropic photobleaching taking place during the operation of one-dimensional PC (1DPC) biosensors sustaining Bloch surface waves (BSW) at their truncation edge. The experimental results are compared to the description provided by our theoretical model reported in a twin article. We demonstrate experimentally that photobleaching affects the response of a cancer biomarkers’ detection assay and propose a procedure to compensate for it. Moreover, we describe the experimental use of BSW-coupled fluorescence and of the strong localization of the BSW at the 1DPC surface to selectively probe the rotational diffusion kinetics of proteins bound at the 1DPC surface with high spatial resolution and for different binding strengths.
First-principles self-energy calculations of carrier-induced band-gap narrowing in silicon (1992)

We calculate the band-gap narrowing in silicon caused by the introduction of additional electrons, using a first-principles self-energy approach within the GW approximation. We include full local-field effects and the nonlocal and energy-dependent dielectric function of the intrinsic material. We also analyze our calculations to test the approximations normally used in simple models of this effect: local-field effects are found to be unimportant, but the inclusion of the energy dependence of the dielectric response of the intrinsic material, which is normally neglected in model calculations, is found to be crucial at high carrier concentrations.
‘Les cytokines responsables’ in osteosclerosis and myelofibrosis (2003)

Myelofibrosis with myeloid metaplasia (MMM) is a clonal stem cell disease that is associated with distinct bone marrow histologic changes that include myelofibrosis, osteosclerosis, and angiogenesis. Chagraoui and colleagues have recently demonstrated, using a combination of blood cell