gebhart/patrepeval huggingface dataset:
ZnS‐based photonic crystal phosphors fabricated using atomic layer deposition (2004)

Abstract The infiltration by atomic layer deposition of three‐dimensional opal structures has been investigated as a means of fabricating photonic crystal phosphors. ZnS:Mn infiltrated and inverse opals have been demonstrated with filling fractions &gt;95%. Characterization of these structures by scanning electron microscopy, specular reflectance, and photoluminescence is reported. Specular reflectance measurements confirm successful infiltration, and demonstrate modification of the electromagnetic density of states consistent with calculated photonic (111) pseudo band gaps. Photoluminescence measurements reveal modification of emission by the photonic crystal consistent with angular dependent specular reflectance measurements. These results reveal a flexible and convenient route for fabricating high performance photonic crystal structures and optical microcavities. (© 2004 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
Metallaphotoredox: The Merger of Photoredox and Transition Metal Catalysis (2021)

The merger of photoredox catalysis with transition metal catalysis, termed metallaphotoredox catalysis, has become a mainstay in synthetic methodology over the past decade. Metallaphotoredox catalysis has combined the unparalleled capacity of transition metal catalysis for bond formation with the broad utility of photoinduced electron- and energy-transfer processes. Photocatalytic substrate activation has allowed the engagement of simple starting materials in metal-mediated bond-forming processes. Moreover, electron or energy transfer directly with key organometallic intermediates has provided novel activation modes entirely complementary to traditional catalytic platforms. This Review details and contextualizes the advancements in molecule construction brought forth by metallaphotocatalysis.
Screening semen donors for hereditary diseases. The Fairfax cryobank experience. (1998)

Screening semen donors for a number of genetic diseases that are passed silently from generation to generation is warranted since family history alone cannot identify them.
Oracle E-Business Suite Manufacturing & Supply Chain Management (2002)

Implement Oracle's Internet-based Manufacturing and Supply Chain Management products using this Oracle authorized resource. This comprehensive guide explains how to implement the planning, engineering, pricing, order fulfillment, and inventory management components of Oracle Manufacturing and Supply Chain--and develop and deliver goods and services faster, cheaper, and more efficiently than your competitors.
Table of contents

PART I: Introduction
Chapter 1: Introduction to Oracle Manufacturing and Supply Chain Products
PART II: Design and Manufacturing Engineering
Chapter 2: Enterprise Structure
Chapter 3: Managing Items
Chapter 4: Managing Bills and Routings
Chapter 5: Design Engineering
Chapter 6: Assemble to Order and Pick to Order
Chapter 7: Manufacturing Engineering
PART III: Supply Chain Planning
Chapter 8: Planning Fundamentals
Chapter 9: Demand Planning
Chapter 10: Single Organization Planning
Chapter 11: Advanced Supply Chain Planning
PART IV: Supply Chain Execution
Chapter 12: Order Management
Chapter 13: Procurement Management
Chapter 14: Receiving
Chapter 15: Inventory and Warehouse Management
Chapter 16: Manufacturing Execution
Chapter 17: Outbound Logistics
PART V: Support Functions
Chapter 18: Costing
Chapter 19: Quality Management
Chapter 20: Pricing
PART VI: Business Intelligence
Chapter 21: Business Intelligence for Manufacturing and Supply Chain
Chapter 22: Case Study: Neptune Corporation
Robust super-resolution without regularization (2008)

This article has been removed from this volume as it was a duplicate of the following article 012037.
Distinct deregulation of the hypoxia inducible factor by PHD2 mutants identified in germline DNA of patients with polycythemia (2011)

As observed with germline von Hippel-Lindau mutations, there are functional differences between the PHD2 mutants with regards to hypoxia inducible factor regulation. PHD2 mutation carriers do, therefore, need careful medical follow-up, since some mutations must be considered as potential candidates for tumor predisposition.
Immunotoxicity of the Pyrrolizidine Alkaloid Monocrotaline following Subchronic Administration to C57BI/6 Mice (1990)

Immunotoxicity of the Pyrrolizidine Alkaloid Monocrotaline following Subchronic Administration to C57B1/6 Mice. DEYO, J. A., AND KHRKVUET, N. I. (1990). Fundam. Appl. Toxicol14, 842–849. Monocrotaline (MCT) is a member of a class of compounds known as pyrrolizidine alkaloids (PAs). PAs are found in the leaves and seeds of a variety of plant species. The potential intoxication of livestock and man through the ingestion of contaminated grains and other foods makes PAs a significant toxicological concern. MCT exposure in rats results in lesions to hepatic and cardiopulmonary tissues as well as alterations in lymphoid organ cellularity. However, no previous studies have investigated MCT-induced functional alterations in the immune system. In the present study, MCT was administered by gavage for 14 days at 0, 10, 25, 50, 75, and 150 mg/kg to female C57B1/6 mice. The antibody-mediated immune response to sheep red blood cells (SRBC) was assessed using the plaque-forming cell (PFC) assay and the hemolytic antibody isotope release assay (HAIR). Additionally, the cytotoxic T-lymphocyte (CTL) response to allo-geneic P815 tumor cells was determined after MCT exposure. Although hepatic and pulmonary lesions are common sequelae to MCT exposure in rats, the C57B1/6 mouse appeared to be more resistant to these effects on the basis of histopathological examination. Furthermore, the overt toxicity of MCT was minimal with respect to organ weight changes in liver, kidney, and lung. In contrast, a dose-dependent suppression in the antibody response to SRBC was observed with a minimum significant dose of 25 mg/kg. At this dose the number of anti-SRBC PFC per 106 spleen cells and the amount of anti-SRBC antibody measured in the HAIR assay were 57 and 59% of control, respectively. The CTL response was significantly decreased (38% of control, 30: 1 E:T), and the total number of CTL lytic units per spleen was 12% of control at 75 mg/kg. Antibody titers to P815 were also dose-dependently suppressed. Therefore, we conclude that the immune system inC57Bl/6 mice is a sensitive target of MCT toxicity.
Handbook of Conformal Mapping with Computer-Aided Visualization (1995)

Mathematics: The Theory of Conformal Mappings Complex Plane, Domains and Curves on It The Analytic Functions of a Complex Variable Conjugate Harmonic Functions The Geometric Meaning of the Derivative Isogonal and Local Conformal Mappings Univalent Analytic Functions. Conformal Mappings of Domains General Principles of the Theory of Conformal Mappings Conformal Mappings Realized by the Basic Elementary Functions Isothermic Coordinates. Differential Operators in the Isothermic Coordinates Mappings of Lunes The Construction of Conformal Mappings with the Help of the Boundary Correspondence Principle The Construction of Conformal Mappings of Curvilinear Strips with the Help of an Analytic Continuation of a Function from the Real Axis The Mapping of Polygonal Domains. Schwarz-Christoffel Integral Mappings of Rectangular Domains. Elliptic Integrals and Elliptic Functions Conformal Mapping of Doubly Connected Domains Physics: Applications of Conformal Mappings Insight into Plane Harmonic Vector Field Plane Harmonic Vector Fields in Physics Complex Potential Boundary-Value Problems for Harmonic Functions The Construction of a Green Function of the Dirichlet Problem The Green Function of the Neumann Problem The Green Function of a Mixed Boundary-Value Problem Point Source and Sink in the Dirichlet Problem Point Source and Sink in the Neumann Problem Plane Robin Problem The Flow in a Curvilinear Angular Domain. Streaming Around an Infinite Curve The Flow in a Curvilinear Strip The Flow in a Curvilinear Strip with N Branches The Flow Running onto an Infinite Curve and Branching on It Irrotational Streaming Around a Finite Contour Mixed Boundary-Value Problem in a Curvilinear Angular Domain. The Simplest Problem of the Filtration Theory Distribution of the Electric Current in a Plate in the Presence of Two Non-Point Electrodes at Its Boundary The General Problem on the Streaming Around a Finite Contour The Problem on the Impact of a Solid Cylinder upon the Surface of a Non-Compressible Liquid The Flow with Branching in a Curvilinear Strip with N Branches Practice: Catalog of Conformal Mappings Finite Domains Exteriors of Finite Contours Curvilinear Angular Domains Curvilinear Strips Curvilinear Strips with N Branches Appendix: Program CONFORM
Multi-Detect Algorithm for multibeam sonar data (2013)

When conducting hydrographic surveys the surveyor has to choose between storing just the bottom detections or the entire water column data. The former may result in vital information being lost, while the latter often requires very large storage capability. This paper presents the Multi-Detect Algorithm (MDA), a method for real-time detection of objects in the water column as well as the seafloor beneath. This method is designed to work in conjunction with existing bottom detection algorithms, as a predetection procedure preceding the normal bottom detection. Results from three different scenarios are used to demonstrate that MDA is able to extract more information from the water column than a typical bottom detection algorithm (BDA). Also presented is data from complex underwater objects and a challenging multipath environment. MDA is shown to offer a viable alternative to storage and postprocessing of water column data, and give more details on complex targets and flexibility in challenging environments.
Self‐Powered Implantable Medical Devices: Photovoltaic Energy Harvesting Review (2020)

Implantable technologies are becoming more widespread for biomedical applications that include physical identification, health diagnosis, monitoring, recording, and treatment of human physiological traits. However, energy harvesting and power generation beneath the human tissue are still a major challenge. In this regard, self-powered implantable devices that scavenge energy from the human body are attractive for long-term monitoring of human physiological traits. Thanks to advancements in material science and nanotechnology, energy harvesting techniques that rely on piezoelectricity, thermoelectricity, biofuel, and radio frequency power transfer are emerging. However, all these techniques suffer from limitations that include low power output, bulky size, or low efficiency. Photovoltaic (PV) energy conversion is one of the most promising candidates for implantable applications due to their higher-power conversion efficiencies and small footprint. Herein, the latest implantable energy harvesting technologies are surveyed. A comparison between the different state-of-the-art power harvesting methods is also provided. Finally, recommendations are provided regarding the feasibility of PV cells as an in vivo energy harvester, with an emphasis on skin penetration, fabrication, encapsulation, durability, biocompatibility, and power management.
Adolfo Bustamante's María la O (1948) and the Cinematic Transformation of Cuban Zarzuela (2016)

Cuban zarzuela flourished for a brief period of time, from the late 1920s to the early 1940s, providing the Western hemisphere with some of its best-loved melodies. The musical and dramatic codes of the zarzuela represented both hegemonic power and social marginality. Composers took preexisting racialized theatrical types and created a phenomenon that was as pedagogical as it was entertaining, instructing Cuba’s growing bourgeoisie about the need for social and racial stability. The zarzuela trafficked in desire, supporting a white-supremacist ideology while simultaneously advocating the consumption of blackness, a strategy that it shared with the larger afrocubanismo movement. The short lifespan of zarzuela in Cuba has frequently been blamed on the rise of cinema, which offered lower admission prices and greater realism. This article contends that rather than replacing the zarzuela, the emerging Cuban and Mexican film industries absorbed and transformed it, appropriating its plots, performance practices, composers, technical designers, and even performers. I explore the zarzuela’s transformation from stage to screen through Mexican filmmaker Adolfo Bustamante’s 1948 adaptation of Ernesto Lecuona’s 1930 zarzuela, Maria la O . The film’s negotiation of its borrowed content is instructive in understanding how the racialized codes of the zarzuela were reworked to speak to a larger Latin American audience. In removing cultural markers, filmmakers effectively excised any sense of subversive ambivalence from their original source material, engaging in a “flattening out” of racialized discourse and performance practice that mirrored trends emanating from the U.S. and Europe.
Comparison of Strain Typing Results for Clostridium difficile Isolates from North America (2011)

Accurate strain typing is critical for understanding the changing epidemiology of Clostridium difficile infections. We typed 350 isolates of toxigenic C. difficile from 2008 to 2009 from seven laboratories in the United States and Canada. Typing was performed by PCR-ribotyping, pulsed-field gel electrophoresis (PFGE), and restriction endonuclease analysis (REA) of whole-cell DNA. The Cepheid Xpert C. difficile test for presumptive identification of 027/NAP1/BI isolates was also tested directly on original stool samples. Of 350 isolates, 244 (70%) were known PCR ribotypes, 224 (68%) were 1 of 8 common REA groups, and 187 (54%) were known PFGE types. Eighty-four isolates typed as 027, NAP1, and BI, and 83 of these were identified as presumptive 027/NAP1/BI by Xpert C. difficile. Eight additional isolates were called presumptive 027/NAP1/BI by Xpert C. difficile, of which three were ribotype 027. Five PCR ribotypes contained multiple REA groups, and three North American pulsed-field (NAP) profiles contained both multiple REA groups and PCR ribotypes. There was modest concordance of results among the three methods for C. difficile strains, including the J strain (ribotype 001 and PFGE NAP2), the toxin A-negative 017 strain (PFGE NAP9 and REA type CF), the 078 animal strain (PFGE NAP7 and REA type BK), and type 106 (PFGE NAP11 and REA type DH). PCR-ribotyping, REA, and PFGE provide different but overlapping patterns of strain clustering. Unlike the other methods, the Xpert C. difficile 027/NAP1/BI assay gave results directly from stool specimens, required only 45 min to complete, but was limited to detection of a single strain type.
Small-Molecule Suppressors of Candida albicans Biofilm Formation Synergistically Enhance the Antifungal Activity of Amphotericin B against Clinical Candida Isolates (2013)

A new class of fungal biofilm inhibitors represented by shearinines D (3) and E (4) were obtained from a Penicillium sp. isolate. The inhibitory activities of 3 and 4 were characterized using a new imaging flow-cytometer technique, which enabled the rapid phenotypic analysis of Candida albicans cell types (budding yeast cells, germ tube cells, pseudohyphae, and hyphae) in biofilm populations. The results were confirmed by experimental data obtained from three-dimensional confocal laser scanning microscopy and 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT) assays. These data indicate that 3 and 4 inhibited C. albicans biofilm formation by blocking the outgrowth of hyphae at a relatively late stage of biofilm development (IC50 = 8.5 and 7.6 μM, respectively). However, 3 and 4 demonstrated comparatively weak activity at disrupting existing biofilms. Compounds 3 and 4 also exhibited synergistic activities with amphotericin B against C. albicans and other clinical Candida isolates by enhancing the potency of amphotericin B up to 8-fold against cells in both developing and established biofilms. These data suggest that the Candida biofilm disruption and amphotericin B potentiating effects of 3 and 4 could be mediated through multiple biological targets. The shearinines are good tools for testing the potential advantages of using adjunctive therapies in combination with antifungals.
Figure S1 from The Transcriptional Regulator Sin3A Contributes to the Oncogenic Potential of STAT3 (2023)

&lt;p&gt;Data depict STAT3 phosphorylation and acetylation in NPM-ALK+ ALCL&lt;/p&gt;
A multimorphic mutation in IRF4 causes human autosomal dominant combined immunodeficiency (2023)

Interferon regulatory factor 4 (IRF4) is a transcription factor (TF) and key regulator of immune cell development and function. We report a recurrent heterozygous mutation in IRF4, p.T95R, causing an autosomal dominant combined immunodeficiency (CID) in seven patients from six unrelated families. The patients exhibited profound susceptibility to opportunistic infections, notably <i>Pneumocystis jirovecii</i>, and presented with agammaglobulinemia. Patients' B cells showed impaired maturation, decreased immunoglobulin isotype switching, and defective plasma cell differentiation, whereas their T cells contained reduced T<sub>H</sub>17 and T<sub>FH</sub> populations and exhibited decreased cytokine production. A knock-in mouse model of heterozygous T95R showed a severe defect in antibody production both at the steady state and after immunization with different types of antigens, consistent with the CID observed in these patients. The IRF4<sup>T95R</sup> variant maps to the TF's DNA binding domain, alters its canonical DNA binding specificities, and results in a simultaneous multimorphic combination of loss, gain, and new functions for IRF4. IRF4<sup>T95R</sup> behaved as a gain-of-function hypermorph by binding to DNA with higher affinity than IRF4<sup>WT</sup>. Despite this increased affinity for DNA, the transcriptional activity on IRF4 canonical genes was reduced, showcasing a hypomorphic activity of IRF4<sup>T95R</sup>. Simultaneously, IRF4<sup>T95R</sup> functions as a neomorph by binding to noncanonical DNA sites to alter the gene expression profile, including the transcription of genes exclusively induced by IRF4<sup>T95R</sup> but not by IRF4<sup>WT</sup>. This previously undescribed multimorphic IRF4 pathophysiology disrupts normal lymphocyte biology, causing human disease.
Nature of cervical involvement in endometrial carcinoma (1987)

In patients with endometrial carcinoma the prognostic significance of clinical and histopathologic variants of cervical involvement is unknown. Fifty-eight patients with endometrial carcinoma and cervical involvement diagnosed by gross examination or endocervical curettage are reviewed. Three clinicopathologic groups were identified: gross cervical involvement (10 patients), occult stromal invasion (25), and no evidence of stromal invasion (23). There were no differences in clinical, pathologic, surgical, or therapeutic characteristics. There was no significant difference in actuarial 5-year survival rates between patients with gross cervical involvement (70%) and occult disease (65%). There was also no significant difference in survival rates among patients with occult cervical stromal invasion (67%). The presence of cervical involvement in endometrial carcinoma is an important prognostic factor. However, the extent of cervical involvement does not appear to be of significant prognostic value.
Direct Growth of Unidirectional Graphene Nanoribbons on Vicinal Ge(001) (2019)

Long, highly oriented, semiconducting graphene nanoribbons (GNRs) are fabricated by chemical vapor deposition (CVD) on Ge(001) substrate. However, these anisotropic nanoribbons are apt to randomly distribute on Ge surface, which hinders their scalable applications in high‐performance graphene electronic devices. In this work, it is proved that the alignment of GNRs is closely related to the miscut angle of vicinal Ge(001) substrate. By investigating the growth behaviors of the GNRs on vicinal Ge(001) substrates with 0°, 4°, 8°, and 12° miscut toward Ge[111], it can be found that GNRs tend to nucleate along the orientation perpendicular to the miscut direction with the increase of miscut angle, and unidirectional GNRs are successfully synthesized on 12° miscut Ge(001) surface. Moreover, the shape of GNRs is also tuned by the miscut angle, which undoubtedly affects the aspect ratio of these GNRs. These promising results demonstrate that synthesizing unidirectional GNRs by the proposed method may promote the application of graphene in future nanoelectronic devices.
PSA decline and objective response rates in White (W), Black (B), and Asian men with metastatic castration-resistant prostate cancer (mCRPC). (2019)

5021 Background: We have shown previously in multivariable analysis that AA men had 19% lower risk of death than C men with metastatic castration resistant prostate cancer (mCRPC) treated with a docetaxel (D) and prednisone (P) based regimen. The primary goal of this analysis was to compare ≥50%PSA decline and objective response rate (ORR) in C men, AA men, and Asian men with mCRPC treated with a DP based regimen. Methods: Individual patient data from 8,151 mCRPC men randomized on eight phase III trials to a D containing regimen were combined. Race used in the analysis was based on self-report. The endpoints were ≥50% PSA decline from baseline defined by the PSA working group 2 and ORR (defined as complete or partial response). The logistic regression model was employed to assess the prognostic importance of race in predicting ≥50% PSA decline and ORR adjusting for treatment arm, performance status, and site of metastases. Results: Of 8,151, 7,687 (94%) patients had evaluable PSA data. Of 7,687 men, 6,535 (85%) were W, 445 (6%) were B, 395 (5%) were Asian and 312 (4%) had race unspecified. Men with race unspecified were excluded from the analysis, leaving 7,375 men. Percentage of patients who experienced PSA decline from baseline were: 64%, 58% and 62% in W, B and Asian men, respectively. In multivariable analysis adjusting for risk factors, the pooled odds ratios for PSA decline for AA vs. W were 0.9 (95% CI = 0.7-1.1, p = 0.16) and 1.0 (95% CI = 0.8-1.2, p = 0.92) for Asian vs. W. In 2,760 patients with measurable disease, the percentage of patients who had ORR were: 39%, 31% and 34% in W, B and Asian men, respectively. In multivariable analysis, the pooled odds ratios for ORR were 1.0 (95% CI = 0.7-1.4) for B vs. W and 0.9 (95% CI = 0.6-1.4) for Asian vs. W. Conclusions: There were no differences in PSA decline and ORR outcomes in W, B, or Asian men with mCRPC enrolled on these phase III clinical trials with DP. Clinical trial information: NCT00110214.
Architecture of an integration and portability platform (1988)

The Software BackPlane is an integration and portability platform that facilitates software tool integration, portability, workflow control, configuration management and shared access to project information. The Software BackPlane provides a consistent user environment based on the X Window standard, portability services using a generic operating system interface, and structured data management, using a multilayered data repository. The author explores architectural alternatives for the data repository. The ANSI/SPARC taxonomy is used to characterize the external, conceptual and internal model of the Software BackPlane's object-oriented data management facilities.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>