gebhart/patrepeval huggingface dataset:
Changes implemented by US oncology practices in response to COVID-19 pandemic: Initial report from the ASCO Registry on COVID-19 and cancer (2020)

Background: In April 2020, ASCO initiated a registry to capture and analyze status and outcomes of patients withcancer and COVID-19, and to describe effects of the pandemic on U S cancer practices Initial findings of changesto care delivery are included Methods: Practices provide data on changes to care delivery due to COVID-19 and longitudinal data on patients with cancer and confirmed COVID-19 At present, 26 cancer practices have enrolled in the Registry-5 academic,15 hospital/health-system (H/HS) owned, and 6 physician-owned (P-O) located in 19 states Enrollment of practicesand data collection is ongoing Results: Twenty sites, from 17 practices (3 academic, 9 H/HS owned, and 5 P-O in 15 states) responded (April 20-June 4) All incorporated telemedicine visits;90% reported use of telemedicine was new 30% reported “decliningsome but not all” new patient requests For patients with cancer not on active therapy, 15% of sites postponed someroutine visits, 35% conducted virtually all routine visits by telemedicine, and 50% used telemedicine for some routinevisits Most sites (95%) reported following clinical guidelines for visit postponement;90% reported following localhealth authorities on when to resume routine visits 90% screened patients prior to in-office visits for COVID-19symptoms by phone and at clinic entrance;10% screened patients using only one method 30% modifiedintravenous (IV) drug infusions, including halting some or all (10%), shortening some or all (20%), or switching fromIV to oral drugs (15%) While no sites conducted home-based, anticancer drug infusions, 30% are considering thisoption if COVID19 conditions change Most sites modified laboratory specimen collection, including allowing acollection site closer to home (60%) and collection in a patient's home (1 site) Two sites only allowed patients onoral anticancer drugs to use alternate collection sites Only 1 site reported specimen collection in patients' homes All reported making the following changes to clinic arrangements: requiring use of masks, eliminatingaccompaniment by a support person (with exceptions), and reducing the visit numbers or increasing time betweenvisits No sites reported shortages of anticancer or supportive care drugs 45% experienced shortages ofnasopharyngeal swabs, 45% of medical hand sanitizer, and 75% of personal protective equipment 40% of siteshave experienced staffing reductions or changes due to reduced patient visits (30%), transfer to other clinical areas(20%), availability (15%), and COVID-19 illness (15%) Conclusions: The COVID-19 pandemic has had a substantial impact on most aspects of cancer care delivery inU S oncology practices All practices incorporated telemedicine, which is new to most Adjustments were made topatient visits and scheduled IV drug infusions Sites reported shortages of equipment related to COVID-19, notcancer or supportive care drug shortages At the time of the AACR meeting we expect to have data from morepractices
Biological Imaging with Medium‐Sensitive Bichromatic Flexible Fluorescent Dyes (2017)

Abstract A family of environment‐sensitive shape‐shifting molecules have been developed as flexible fluorescent (FlexFluor) dyes for biological imaging applications. These compounds feature a flexible bithiophene‐based fluorophore that gives rise to different emission colors in lipophilic or hydrophilic environments, as well as side groups that can be synthetically modified with ease. FlexFluor dyes are the first fluorescent dyes in which emission color can be used to indicate lipid/water environments. The behavior of these dyes in different solvents was studied, and used to simultaneously highlight lipid and water contents in adipose and brain tissues using optical fluorescence microscopy.
Plan Elements (2017)

Suppose we are watching a workman doing his job.He looks around for his toolbox, and when he finds it, he opens it and takes out a hammer and nails. He pounds one nail after another into boards. Each step in this repetitive action is itself a repetitive action, hitting the nail with the hammer again and again until it is flush with the wood. He sweats, and from time to time as the sweat drips into his eyes, he takes out a handkerchief and wipes his brow. Five o'clock comes, and he puts his tools away and goes home. He comes back the next morning at nine o'clock for a day of similar tasks.
Supplementary Method from Silencing of Long Noncoding RNA <i>MIR22HG</i> Triggers Cell Survival/Death Signaling via Oncogenes YBX1, MET, and p21 in Lung Cancer (2023)

&lt;p&gt;Supplementary Methods about RNAs extraction and quantitative real-time RT-PCR, proteins extraction, immunoblot analysis and tissue array, cell cycle analysis by flow cytometry, and MIR22HG lentiviral expression construct transfection.&lt;/p&gt;
Sorting of Micro-particles using Magnetically Driven Micro-tools (2009)

This paper describes a novel non-contact manipulation system using on-chip magnetically driven micro-tools (MMT). This system has sorting function of particles one by one with MMT. It has unique feature of installation of MMT directly in a microchannel which is unlike to the conventional cell sorter systems. The drive unit was remarkably downsized by using an amplification mechanism of magnetic power actuated by electromagnets. We have demonstrated sorting of micro-beads automatically based on trigger signals generated by real-time image recognition. The proposed method can be extended to the environmental particulate analysis, cell sorting system and so on.
An Abundant Tissue Macrophage Population in the Adult Murine Heart with a Distinct Alternatively-Activated Macrophage Profile (2012)

Cardiac tissue macrophages (cTMs) are a previously uncharacterised cell type that we have identified and characterise here as an abundant GFP(+) population within the adult Cx(3)cr1(GFP/+) knock-in mouse heart. They comprise the predominant myeloid cell population in the myocardium, and are found throughout myocardial interstitial spaces interacting directly with capillary endothelial cells and cardiomyocytes. Flow cytometry-based immunophenotyping shows that cTMs exhibit canonical macrophage markers. Gene expression analysis shows that cTMs (CD45(+)CD11b(+)GFP(+)) are distinct from mononuclear CD45(+)CD11b(+)GFP(+) cells sorted from the spleen and brain of adult Cx(3)cr1(GFP/+) mice. Gene expression profiling reveals that cTMs closely resemble alternatively-activated anti-inflammatory M2 macrophages, expressing a number of M2 markers, including Mrc1, CD163, and Lyve-1. While cTMs perform normal tissue macrophage homeostatic functions, they also exhibit a distinct phenotype, involving secretion of salutary factors (including IGF-1) and immune modulation. In summary, the characterisation of cTMs at the cellular and molecular level defines a potentially important role for these cells in cardiac homeostasis.
Fairness and Welfare Through Redistribution When Utility Is Transferable (2021)

We join the goals of two giant and related fields of research in group decision-making that have historically had little contact: fair division, and efficient mechanism design with monetary payments. To do this we adopt the standard mechanism design paradigm where utility is assumed to be quasilinear and thus transferable across agents. We generalize the traditional binary criteria of envy-freeness, proportionality, and efficiency (welfare) to measures of degree that range between 0 and 1. We demonstrate that in the canonical fair division settings under any allocatively-efficient mechanism the worst-case welfare rate is 0 and disproportionality rate is 1; in other words, the worst-case results are as bad as possible. This strongly motivates an average-case analysis. We then set as the goal identification of a mechanism that achieves high welfare, low envy, and low disproportionality in expectation across a spectrum of fair division settings. We establish that the VCG mechanism is not a satisfactory candidate, but the redistribution mechanism of [Bailey, 1997; Cavallo, 2006] is.
Synthesis of 1‐amino‐2‐β‐(3‐ [2,6‐14C] piperidinome thylphenoxy) propylamino ‐1‐cyclobutene‐3,4‐dione hydrochloride (1985)

Abstract The synthesis of the title compound (6) is described. The condensation of 3‐aminopropanol with phthalic anhydride and subsequent treatment with phosphorous tribromide produced N‐[3‐bromopropyl] phthalimide. Acylation with 3‐hydroxybenzaldehyde, reduction with hydrogen over Raney nickel and subsequent treatment with thionyl chloride gave N‐[ 3‐(3‐chloromethylphenoxy) propyl ] phthalimide (2). Treatment with [2, 6 ‐ 14 C] piperidine introduced the radiolabel (3). Deprotection of the amino group with hydrazine and treatment with 3‐methoxy‐4‐amino‐3‐cyclobutene‐1,2‐dione produced 1‐amino‐2‐ [3‐(3‐[ 2,6‐ 14 C] piperidinome thylphenoxy) propylamino ]‐1‐cyclobutene‐3, 4‐dione (5). Treatment with hydrochloric acid yielded the title compound (6) in an overall chemical yield of 22%.
Exoskeleton Technology in Rehabilitation: Towards an EMG-Based Orthosis System for Upper Limb Neuromotor Rehabilitation (2013)

The rehabilitation of patients should not only be limited to the first phases during intense hospital care but also support and therapy should be guaranteed in later stages, especially during daily life activities if the patient’s state requires this. However, aid should only be given to the patient if needed and as much as it is required. To allow this, automatic self-initiated movement support and patient-cooperative control strategies have to be developed and integrated into assistive systems. In this work, we first give an overview of different kinds of neuromuscular diseases, review different forms of therapy, and explain possible fields of rehabilitation and benefits of robotic aided rehabilitation. Next, the mechanical design and control scheme of an upper limb orthosis for rehabilitation are presented. Two control models for the orthosis are explained which compute the triggering function and the level of assistance provided by the device. As input to the model fused sensor data from the orthosis and physiology data in terms of electromyography (EMG) signals are used.
[Optimization of PET image quality by means of 3D data acquisition and iterative image reconstruction]. (1998)

Our measurements show that the image quality in 3D PET can be improved by using iterative reconstruction techniques. The concept of 3D data acquisition and combining the FORE algorithm with 2D ML/EM reconstruction can readily be employed in clinical practice since the computation time is not considerably longer than that in iterative reconstruction of true 2D data.
Events Surrounding the Early Development of Euglena Chloroplasts (1979)

Lack of a suitable assay has thwarted attempts to measure cytochrome c-552 in dark-grown wild type cells of Euglena gracilis var. bacillaris in mutants and in other situations where the concentrations are low. Purification methods are described based on electrofocusing which provide a cytochrome c-552 preparation homogeneous enough to elicit a single reactive antibody in rabbits; this antibody is then used as a specific and sensitive assay for cytochrome c-552. Dark-grown cells of wild type and of mutants O(1)BS, O(2)BX, G(1)BU and P(1)BXL (which make normal sized chloroplasts with abnormal internal structure in the light) have 0.02 to 0.1 x 10(-11) micromoles of cytochrome c-552 per cell, 10 to 150 times less than light-grown cells. Light-grown cells of these mutants and of wild type show a ratio of chlorophyll to cytochrome of about 300 (mole to mole). Cytochrome c-552 is undetectable in dark-grown Y(1)BXD, Y(3)BUD, and W(34)ZUD which cannot carry plastid development beyond the proplastid in light; the light-grown cells of these mutants have levels of cytochrome similar to or lower than dark-grown wild type cells. Cytochrome c-552 is undetectable in light- and dark-grown mutants in which plastid DNA is undetectable (such as Y(2)BUL, W(3)BUL, W(8)BHL, and W(10)BSmL) consistent with the view, but not proving, that this molecule may be coded, at least in part, in plastid DNA. During light-induced chloroplast development in resting cells, cytochrome c-552 formation behaves in all respects like chlorophyll except that the dark-grown cells contain low amounts of the cytochrome c-552 but lack chlorophyll. Thus, both cytochrome c-552 and chlorophyll show the same lag period even when the length is changed by nutritional manipulation; preillumination largely eliminates the lag in the formation of both molecules, cycloheximide and streptomycin both inhibit the biosynthesis of chlorophyll and cytochrome c-552 in the same manner, and the formation of both during chloroplast development is strictly light-dependent. It is shown that chloroplasts isolated from Euglena by methods thought to give intact organelles, lack 95% of the cytochrome c-552; this and the loss of similar molecules may explain why these isolated chloroplasts are not photosynthetically active.
Functional properties of human factor Va lacking the Asp683-Arg709 domain of the heavy chain. (1994)

A protease purified from the venom of the elapid snake Naja naja oxiana converts human blood coagulation factor Va into a molecule (factor VaNO) with greatly reduced cofactor activity. Polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate revealed that the venom protease cleaved a small peptide from the heavy chain of factor Va and reduced the apparent M(r) from 105,000 to 101,000. This peptide was isolated by high performance liquid chromatography on a reversed-phase column. Amino acid sequence analysis of the peptide indicated that the venom enzyme cleaved the peptide bond between His682 and Asp683, thus removing 27 amino acids from the carboxyl-terminal part of the heavy chain. The cofactor activities of factors Va and VaNO were compared by measuring their abilities to support factor Xa-catalyzed prothrombin activation in the presence of phospholipids and calcium ions. Both factor Va molecules stimulated the binding of factor Xa to negatively charged phospholipids. However, the amounts of factor Va required for half-maximal incorporation of factor Xa into the membrane-bound factor Xa-Va complex were much lower for native factor Va (0.25 nM) than for factor VaNO (2.01 nM). At saturating concentrations of factor Va or factor VaNO the kcat values for prothrombin activation were 114 s-1 for factor Va and 128 s-1 for factor VaNO. The Km values for prothrombin determined under these conditions were 0.24 and 0.83 microM for prothrombinase complexes with native factor Va and factor VaNO, respectively. Direct binding studies revealed that factors Va and VaNO bind with equal affinity to phospholipids. These data indicate that factor VaNO is impaired in its ability to interact with factor Xa and prothrombin. Together with the structural data this implies that the carboxyl-terminal Asp683-Arg709 domain of the heavy chain is required for optimal interaction of factor Va with factor Xa and prothrombin.
Effect of low dose acetylsalicylic acid and anticoagulant on clinical outcomes in COVID‐19, analytical cross‐sectional study (2022)

Low-dose ASA has a nonsignificant but potentially protective role in reducing the risk of COVID-19 related morbidity and mortality. Our data suggests a trend toward reduced 30-day readmission rates, ARDS, MICU admissions, need for mechanical ventilation, and mortality compared to the standard management protocol. Further randomized control trials are needed to establish causal effects.
Effects of lattice distortion on the physical properties and surface morphology of magnetoresistive perovskite epitaxial films (1997)

The effects of lattice distortion on the physical properties of La0.7Ca0.3MnO3 epitaxial films are investigated. Our results suggest that larger substrate-induced lattice distortion gives rise to larger zero-field resistivity and larger negative magnetoresistance. Similar effects are also observed in samples of different thicknesses and on the same substrate material, with larger resistivity and magnetoresistance associated with thinner samples. In addition to x-ray diffraction spectroscopy, the degrees of lattice distortion in different samples are further verified by the surface topography taken with a low-temperature scanning tunneling microscope. Quantitative analyses of the transport properties suggest that the high-temperature (T→TC) colossal magnetoresistance (CMR) in the manganites is consistent with the conduction of lattice polarons induced by the Jahn–Teller coupling, and that the low-temperature (T≪TC) magnetoresistance may be attributed to the magnetic domain wall scattering. In contrast, the absence of the Jahn–Teller coupling and the large conductivity in La0.5Ca0.5CoO3 epitaxial films yield much smaller negative magnetoresistance, which may be attributed to disorder-spin scattering.
Strong Field Double-Ionization of Water (2017)

The dissociation of water into OH+-H+ in 40-fs laser pulses shows tunnel ionization out of lower- lying orbitals. Our kinematically-complete experiment identifies ionization pathways by scanning wavelength (266 nm to 800 nm) and intensity.
Viscoelastic properties of supramolecular gemini-like surfactant solutions in the absence of inorganic salts (2017)

A bola-type cation and a newly synthesized anionic surfactant together generate a supramolecular gemini-like structure<italic>via</italic>electrostatic interactions, which facilitates the formation of wormlike micelles.
Benzylamines as Versatile Agents for the One‐Pot Synthesis and Highly Ordered Stacking of Anatase Nanoplatelets (2008)

Abstract The simple reaction of titanium isopropoxide in benzylamine is shown to lead to remarkably complex, highly ordered hybrid structures. These structures consist of anatase nanoplatelets that were stacked in a lamellar fashion with a small organic layer in between. By careful characterization of these structures, we show that indeed solely the benzylamine solvent is present in the organic moiety between the nanocrystals, which thereby provides both shape control and alignment of the inorganic crystals. The solvent also plays a central role during the anatase formation itself; hence, it enacts control on the forming materials on a multitude of levels.(© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2008)
Ticket Validation in Public Transportation Using the Smartphone (2015)

The adoption of smartphones worlwide grows everyday and it is becoming a part of our everyday life, making it easier and always connected to the world. Furthermore, a bigger integration of this technology with mundane tasks is sought after. It is then in the context of this desire that this dissertation comes to light, by finding a way to integrate the smartphone with something that is a part of a significant number of people's daily commute: public transportation. Public transportation is an important part of our society, since many depend on it everyday, in order to fulfill their daily travelling needs, like going to work, going home, going shopping and meeting friends. With that in mind, it is clear the utmost importance of further improving this infrastructure, by allowing commuters to use their smartphone to perform tickets' validation. This work provides a comparison and analysis of the use and costs of different technologies (i.e. NFC, QR Codes, Bluetooth and Location data), in the validation process of public transportation tickets. Aspects like the cost, device compatibility and ease of use are discussed and compared. After analyzing and comparing each technology, QR Codes and Location data were used to design 3 possible solutions to implement a mechanism that allows users to validate their tickets using their smartphone. With the chosen solution, an Android application and web server were implemented, which allows the validation of tickets. Other functionalities were implemented, in order to further approximate it to a production application, such as buying tickets and listing the past trips. The created application was later on tested both in laboratory environment and in a real environment, with the company responsible for bus transportation in Porto's transportation system, STCP, and its respective customers. Two questionnaires were also sent to the experiment's participants, one before and one after, in order to determine the type of transportation users that were going to participate in the experiment and also gather feedback from them, about the created system. In the end, it was possible to produce a solution that would be interesting to implement in a real scenario. The application and the experiment done proved that is possible to implement a ticket validation solution using the smartphone, with the least possible cost while maintaining the reliability needed in such a system. It was also possible to conclude that there is a high interest from the users' side in the use of a such a system. So, creating a system that is easy to use for the users and that has low distribution and maintenance costs for the operators would be beneficial for both sides.
LRP-1 Silencing Prevents Malignant Cell Invasion despite Increased Pericellular Proteolytic Activities (2008)

The scavenger receptor low-density lipoprotein receptor-related protein 1 (LRP-1) mediates the clearance of a variety of biological molecules from the pericellular environment, including proteinases which degrade the extracellular matrix in cancer progression. However, its accurate functions remain poorly explored and highly controversial. Here we show that LRP-1 silencing by RNA interference results in a drastic inhibition of cell invasion despite a strong stimulation of pericellular matrix metalloproteinase 2 and urokinase-type plasminogen activator proteolytic activities. Cell migration in both two and three dimensions is decreased by LRP-1 silencing. LRP-1-silenced carcinoma cells, which are characterized by major cytoskeleton rearrangements, display atypical overspread morphology with a lack of membrane extensions. LRP-1 silencing accelerates cell attachment, inhibits cell-substrate deadhesion, and induces the accumulation, at the cell periphery, of abundant talin-containing focal adhesion complexes deprived of FAK and paxillin. We conclude that in addition to its role in ligand binding and endocytosis, LRP-1 regulates cytoskeletal organization and adhesive complex turnover in malignant cells by modulating the focal complex composition, thereby promoting invasion.
Layered Protection of Availability (1997)

Of the three common objectives of information seurity,availability is far less understood than con dentiality and integrity of information. As threats against availability are too numerous to be identi ed, a di ernt approach is required for the protection. In this paper, a layered protection of availability shall be established, and the cost of protection shall be justi ed at each layer. A very large scope shall be taken, where violations of availability cover both intentional and accidental threats originating from both external and internal sources. Di erent layers required re ect the di erent nature of these threats. 1
Manifolds defined by points: Parameterizing and boundary detection (extended abstract) (2016)

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