gebhart/patrepeval huggingface dataset:
Regulation of plasmacytoid dendritic cell development in mice by aryl hydrocarbon receptor (2013)

Aryl hydrocarbon receptor (AhR) has an important role in the regulation of cell responses to different environmental stimuli, as well as to various endogenous ligands. Although AhR was previously implicated in the regulation of dendritic cell (DC) activation, very little is known about its potential role in the development of these cells. Here we report our unexpected findings that AhR may regulate the differentiation of plasmacytoid DCs (pDCs). Agonist of AhR markedly decreased the generation of pDCs in vitro, whereas the AhR antagonist had an opposite effect. The differentiation of conventional DCs (cDCs) was not affected. AhR-knockout mice had a substantial accumulation of pDCs in peripheral lymphoid organs; whereas no changes in cDCs were seen. Thus, this study has identified AhR as a transcription factor involved in the development of one population of DCs-pDCs.
Shear rate behaviour within in vitro thrombotic geometries: height and surface curvature dependence. (2012)

The flow of blood past thrombi, situated within an in vitro geometry, is computed via the solution fo the three‐dimensional (3D) Navier‐Stokes equations. The thrombotic geometry is derived from microscopy measurements of thrombotic geometries within in vitro experiments which the in silico experiment reflects. The flow within the numerical domain is solved using the OpenFOAM package to provide an solution of the steady state and incompressible Navier‐Stokes equations. Previous work (Butler et al, 2012) explored the shear rate variations that occur in a simplified thrombotic geometry. Here additional flow complexity is introduced through the complexity of the thrombus geometry. Localised fluctuations of the thrombus surface are shown to generate significant variations in the shear‐rate the thrombus surface experiences. Convex and exposed surfaces are shown to have the highest shear rates. In addition to the concavity the height above the microchannel floor is shown to correlate strongly with increased shear rate.
A comparative study of video signals for non-contact heart rate measurement (2015)

This paper describes a comparative study of the various color signals for non-contact heart rate (HR) measurement on a video sequence. The color signals include red, green, blue, hue, the principal components of the red, green, and blue signals from video data. Experimental results prove that hue and the 3rd principal component are the most effective signals for the HR measurement. Experimental results also show that the two signals behave differently to different lighting conditions. Thus, we have integrated the two signals and achieved an improved performance than those based on a single color signal.
Effects of aerosolized surfactant in patients with stable chronic bronchitis: a prospective randomized controlled trial (1997)

Aerosolized surfactant improved pulmonary function and resulted in a dose-related improvement in sputum transport by cilia in patients with stable chronic bronchitis.
Covid-19 Dermatoses: Acral Vesicular Pattern Evolving into Bullous Pemphigoid (2020)

Abstract Bullous pemphigoid (BP) appears to be rising in incidence across the Western World, especially in the elderly. Some of the pathogenetic mechanisms involving antigen mimicry and antibody cross-reactivity have been elucidated for cases associated with neurological disease and certain drugs. There have been reports of cutaneous manifestations of Covid-19 (SARS-Cov2 infection) as the pandemic has raged across the world. We report here a case of prolonged Covid-19, symptomatic with dermatoses only, which was seen to evolve initially from a maculo-papular exanthema with acral vesicular dermatitis, into classical BP disease. This was confirmed histologically by positive skin autoantibody serology, direct IMF on peri-lesional skin and also salt-split IMF. Although possible that the development of BP could be a purely co-incidental finding during Covid-19, we suggest that it is more likely that prolonged SARS-Cov2 infection triggered an autoimmune response to the basement membrane antigens, BP 180 and 230. To our knowledge, this is the first case of BP developing during concurrent Covid-19 disease. It will be necessary to continue dermatological surveillance as the pandemic continues, to collate data on BP incidence and to test these patients for Covid-19 disease. As the pandemic continues, even potential and rare associations such as this will be clarified eventually. What's already known about this topic? •Covid-19 disease has been associated with a spectrum of dermatoses•Common presentations in up to 20% of patients include exanthema, pseudo-chilblain like acral lesions ‘Covid toes’, livedo-/retiform purpuric/necrotic vascular lesions, acute urticarial lesions, and vesicular/varicella-like lesions•A multi-system inflammatory syndrome in children akin to Kawasaki syndrome has been described What does this study add? •To our knowledge, this is the first description of classic Bullous Pemphigoid evolving from vesicular lesions caused by prolonged SARS-Cov2 induced skin inflammation
Einfluss von ETBE und TAME auf Funktion und Diversität der Bodenmikroflora (2009)

Unsere Untersuchung zeigt zum ersten Mal, dass die Kraftstoffadditive ETBE (Ethyl tert Butylether)und TAME(Tert Amylmethylether) die Zusammensetzung der Bodenmikroflora ändern und darüber hinaus die Akkumulation von Ammonium und Nitrit im Boden verursachen können.
Toward a Computational Tool Predicting the Stereochemical Outcome of Asymmetric Reactions. 1. Application to Sharpless Asymmetric Dihydroxylation (2002)

A reliable and computationally tractable protocol directed at the study of the stereochemical outcome of asymmetric reactions and its application to the Sharpless asymmetric dihydroxylation reaction are proposed. This method, based on a genetic algorithm and molecular mechanics, effectively provides qualitative as well as semiquantitative results and explains the origin of the observed enantioselectivity. For instance, the method reliably predicts reversal of selectivity between similar substrates, unexpected isomers, and even enantio- and diastereoisomeric excess with good accuracy. Two binding modes, closely related to those proposed by Sharpless and Corey, are favored. After comparison with Sharpless' mnemonic device, we propose two alternative interpretations.
Development of porous, antibacterial and biocompatible GO/n-HAp/bacterial cellulose/β-glucan biocomposite scaffold for bone tissue engineering (2020)

Due to their potential renewable materials-based tissue engineering scaffolds has gained more attention. Therefore, researchers are looking for new materials to be used as a scaffold. In this study, we have focused on the development of a nanocomposite scaffold for bone tissue engineering (using bacterial cellulose (BC) and β-glucan (β-G)) via free radical polymerization and freeze-drying technique. Hydroxyapatite nanoparticles (n-HAp) and graphene oxide (GO) were added as reinforcement materials. The structural changes, surface morphology, porosity, and mechanical properties were investigated through spectroscopic and analytical techniques like Fourier transformation infrared (FT-IR), scanning electron microscope (SEM), Brunauer–Emmett-Teller (BET), and universal testing machine Instron. The scaffolds showed remarkable stability, aqueous degradation, spongy morphology, porosity, and mechanical properties. Antibacterial activities were performed against gram -ive and gram + ive bacterial strains. The BgC-1.4 scaffold was found more antibacterial compared to BgC-1.3, BgC-1.2, and BgC-1.1. The cell culture and cytotoxicity were evaluated using the MC3T3-E1 cell line. More cell growth was observed onto BgC-1.4 due to its uniform interrelated pores distribution, surface roughness, better mechanical properties, considerable biochemical affinity towards cell adhesion, proliferation, and biocompatibility. These nanocomposite scaffolds can be potential biomaterials for fractured bones in orthopedic tissue engineering.
A Major Direct GABAergic Pathway from Zona Incerta to Neocortex (1990)

Retrograde fluorescent tracers were used to demonstrate a previously unknown but sizable direct gamma-aminobutyric acid (GABA)-containing neuronal pathway from the zona incerta to the neocortex in rats. This incertocortical pathway was found to project bilaterally to the entire neocortex and exhibited a rough corticotopic organization. Many of the zona incerta neurons projecting to the parietal and occipital cortices could also be immunohistochemically stained with antibodies to glutamic acid decarboxylase and GABA. Few of these neurons were immunoreactive to tyrosine hydroxylase antibodies, which identify dopamine-containing neurons. Injections in the frontal and entorhinal cortices labeled many neurons near or within the dopaminergic A13 subdivision of the zona incerta. In addition, the incertocortical system was found to be significantly larger during early postnatal (2 to 3 weeks) development. The projection pattern of this newly discovered pathway resembles that of the monoaminergic and cholinergic systems, arising from the brainstem and forebrain, suggesting possible similarities of function.
Removal and Refixation of Surface Ig from Isolated Rat Mast Cells (1977)

This study showed that under well-defined conditions all immunoglobulins could be removed from the rat mast cell surface. Surface immunoglobulins were examined by immunofluorescence technique, and cell function by the allergic reaction to antigen as judged by histamine release. Refixation of eluted surface Ig to the mast cell was easily accomplished. Furthermore, fixation of specific surface Ig to already sensitized cells resulted in increased cell sensitivity to antigen, whereas fixation of nonspecific surface Ig resulted in decreased sensitivity. The results indicate that removed immunoglobulins are intact, have affinity for mast cells, and are able to compete with cell-bound Ig.
The effect of short fasting on the hypothalamic neuronal system of kisspeptin in prepubertal female sheep (2011)

International audience
Magnetic modulation of release of macromolecules from polymers. (1981)

Sustained-release systems were made by incorporating bovine serum albumin and magnetic steel beads in an ethylene-vinyl acetate copolymer matrix. When exposed to aqueous medium, the polymer matrix released the albumin slowly and continuously. Application of an oscillating magnetic field increased the release rate by as much as 100%. Intervals of 6-hr periods of magnetic exposure and nonexposure were alternated over a 5-day period, resulting in corresponding increases and decreases in release and establishing a pattern of modulated sustained release.
Grid Voltage Control Analysis for Heavy-Duty Electric Vehicle Charging Stations: Preprint (2021)

This paper presents an analysis of voltage control strategies for heavy duty electric vehicle (EV) charging stations. The performance of three voltage control approaches including power factor control, preset volt-var curve control, and customized volt-var curve control, have been investigated and evaluated for three different sizes of charging stations, including single-port small charging station, three-port middle size charging station, and 6-port travel center. The charging stations have been placed on various locations of four different types of distribution systems, to obtain a comprehensive performance analysis of the three voltage control approaches under different scenarios. To quantitively compare the performance of the three voltage control approaches, a series of metrics have been designed to quantify the performance and contribute to the comprehensive analysis summary.
European Internal Market and Foreing Direct Investment. The Determinants of Fdi (2009)

In this paper we intended to analyse the effects that the incorporation of ten candidate states to the EU- in May 2004- will have over their economies. We studied the role that foreign direct investment (FDI) has played in these countries. We also showed how a country attracts FDI, taking into account size and other factors to which foreign investors are sensitive. In this connection, we monitored several indices to consider social, political and institutional factors which can be relevant to foreign investors from a competitive point of view. Another question to be answered is whether the new regional integration would modify the location of activities in the European countries. We will analyse this question by the role of multinationals companies across Europe.
Plasma Metabolites Associated with OCT Features of Age-Related Macular Degeneration (2023)

Proprietary or commercial disclosure may be found after the references.
Low threshold current and high output power operationfor 1.5 µmGRINSCH strained MQW laser diode (1995)

A low threshold current of 1.8 mA and large slope efficiency of 0.30 mW/mA were obtained using 1.5 µm GRINSCH strained MQW laser diodes. High-temperature operation was confirmed, and the threshold current at 80°C was 5.0 mA with a slope efficiency of 0.18 mW/mA. The device had a short carrier lifetime of less than 1.55 ns.
Regulation and Function of the Cytokine-Inducible SH-2 Domain Proteins, CIS and SOCS3, in Mammary Epithelial Cells (2002)

The cytokine-inducible src homology 2 (SH-2) proteins, CIS (cytokine inducible SH-2 domain protein) and SOCS3 (suppressor of cytokine signaling 3), are implicated in the negative regulation of prolactin (PRL) receptor-mediated activation of signal transducer and activator of transcription 5 (STAT5). We have studied the expression and function of CIS and SOCS3 proteins in the mouse mammary gland and in HC11 mammary epithelial cells. CIS and SOCS3 were differentially regulated: high expression levels of CIS mRNA were measured during the second half of pregnancy, whereas SOCS3 expression was high during the first 12 d post conceptum. SOCS3 levels increased, whereas CIS levels decreased, in the initial phase of involution. At the beginning of the lactation period both CIS and SOCS3 were high. PRL and epidermal growth factor (EGF) were able to induce CIS and SOCS3, whereas glucocorticoids inhibited their expression in mammary epithelial cells. The effect of EGF was much stronger on SOCS3 than on CIS. Ectopic expression of both SOCS3 and CIS inhibited STAT5 activation. Our data indicate that in the mammary gland CIS and SOCS3 are involved in regulating STAT5 signaling at three different instances: 1) SOCS3 serves as a mediator of the inhibitory EGF effect on PRL-induced STAT5 activation; 2) CIS and SOCS3 play a role as negative feedback inhibitors of PRL action; 3) Inhibition of CIS and SOCS3 expression by glucocorticoids contributes to the positive effect of glucocorticoids on PRL-induced STAT5 activation.
A surface micromachined microtactile sensor array (2002)

This paper discusses the design and testing of an eight-by-eight tactile capacitive array sensor for detection of sub-millimeter features and objects, where the entire sensor array is smaller than normal human spatial resolution of 1 mm. Each square taction is less than 100 /spl mu/m on a side, with similar spacing between elements. The structural material was doped polysilicon with an air gap dielectric of 0.5 /spl mu/m. A thin (50-80 /spl mu/m) protective layer of silicone rubber was adhered to the polysilicon surface of the sensor to provide interpolation of normal loads between elements. The sensors were tested and possessed good spatial uniformity, the capability of detecting millinewton forces, and good interpolation between elements. The sensors had severe hysteresis problems, but no detectable proximity effects.
Clinical performance of three dentine bonding agents in Class V abrasion lesions without enamel etching (1988)

Abstract Seventy‐six Class V non‐undercut abrasion lesions were restored with composite and either Dentine Adhesive,† Bondlite,‡ ; or Dentin Bonding Agent ,§ without enamel etching. Restorations were trimmed and polished after approximately three weeks, and evaluated for integrity and marginal staining. Recall evaluations were carried out at three months, six months and one year. The cumulative loss incidence at one year for Dentine Adhesive, Bondlite , and Dentin Bonding Agent was 83 per cent, 25 per cent, and 33 per cent, respectively. Restorations with Dentin Bonding Agent had the most severe marginal staining, while Bondlite restorations had least marginal staining.
Growth and Regression of the Germfree (Axenic) Thymus. (1965)

SummaryQualitatively, the growth patterns of the thymus of germfree and conventional mice are very similar, and the gross appearance is the same. In both groups of animals the period of thymus growth extends from birth to about 50 days, with accelerated growth during the first 2 weeks after birth, and peaks at about 15 days. Growth continues at a decelerated rate and regression of the thymus begins at about 50 days of age. A plateau is reached at about 200 days of age, but the thymus does not disappear completely. However, the thymus of conventional mice grows more rapidly and attains greater size than that of the germ-free mice.
A mobile sensing architecture for massive urban scanning (2011)

Mobile Sensor Networks based on connected vehicles and smart phones are poised to become key enablers in the development of sustainable and intelligent transportation systems in urban environments. By gathering and processing massive amounts of data in real-time, this form of information and communication infrastructure can be instrumental towards improving traffic flow, reducing carbon emissions and promoting multi-modal mobility and enhanced coordination among public transit systems. We propose a system architecture for a Massive Multi-Sensor Urban Scanner capable of acquiring large quantities of real-time information from a vast variety of sources and sending the data to a back-end data processing cloud using multiple communication interfaces. Requirements, technical challenges, design choices and first results are explained in detail based on a prototype that is currently being deployed in Porto, Portugal.
Simulation-based flexible ureteroscopy training using a novel ureteroscopy part-task trainer (2015)

This study demonstrates that a SBT curriculum for fURS can lead to improved short-term technical skills among junior level urology residents. The Cook URS model demonstrated good face, content and construct validity.
Novel organoboron compounds derived from thieno[3,2-b]thiophene and triphenylamine units for OLED devices (2016)

Two novel D–A (donor–acceptor) and one D–A–D small molecules containing mesitylborane as an acceptor and triphenylamine as a donor, linked through a thieno[3,2-<italic>b</italic>]thiophene π-conjugated spacer, are synthesized and characterized.
31P NMR spectra of alkalophilic Bacillus No. A-59. (1981)

Recently Salhany et al.l) applied the technique of 31P nuclear magnetic resonance (NMR) to intact yeast cells, and determined signals due to the inorganic phosphate and organic phosphates at various pH. In this report using 31P NMR we detected phosphate compounds in cells of alkalophilic Bacillus No. A-592) and identified the structure. A standard medium used was (g/liter): soluble starch, 15; polypeptone, 10; yeast extract, 2.5; K2HPO4, 1.0; MgSO4-7H2O, 0.2 and Na2CO3, 10. Na2CO3 and the
Automatic detection of contrast injection on fluoroscopy and angiography for image guided trans-catheter aortic valve implantations (TAVI) (2011)

Presentation of detailed anatomical structures via 3-D models helps navigation and deployment of the prosthetic valve in TAVI procedures. Fast and automatic contrast detection in the aortic root on X-ray images facilitates a seamless workflow to utilize the 3-D models by triggering 2-D/3-D registration automatically when motion compensation is needed. In this paper, we propose a novel method for automatic detection of contrast injection in the aortic root on fluoroscopic and angiographic sequences. The proposed method is based on histogram analysis and likelihood ratio test, and is robust to variations in the background, the density and volume of the injected contrast, and the size of the aorta. The performance of the proposed algorithm was evaluated on 26 sequences from 5 patients and 3 clinical sites, with 16 out of 17 contrast injections correctly detected and zero false detections. The proposed method is of general form and can be extended for detection of contrast injection in other organs and/or applications.
Interaction of antigen-specific T cell factors with unique "receptors" on the surface of mast cells: demonstration in vitro by an indirect rosetting technique. (1986)

Picryl (trinitrophenyl) chloride (PCL) contact sensitization of mice induces T cells that release an antigen-binding T cell factor (PCLF) that plays an important role in the initiation of contact sensitivity responses, in part via activation of mast cells. The current study employs an in vitro indirect rosette assay to demonstrate that PCLF can interact with the mast cell surface. Sheep red blood cells (SRBC) were hapten conjugated with trinitrophenyl (TNP), dinitrophenyl (DNP), or oxazolone (OX). When TNP-conjugated SRBC were coated with PCLF, monoclonal anti-DNP IgE, or anti-DNP IgG1, they produced 40 to 50% rosettes with purified normal mouse peritoneal mast cells. Analogous antigen-binding factors, from lymphoid cells of OX and dinitrofluorobenzene contact-sensitized mice, gave similar mast cell rosetting levels with OX-SRBC and DNP-SRBC, respectively. PCLF demonstrated a high degree of hapten specificity in that it formed rosettes with TNP-SRBC but not with DNP-SRBC, unlike IgE and IgG1, or DNPF, which formed rosettes with either SRBC type. Similarly, soluble TNP-BSA could inhibit PCLF rosette-forming capacity, but soluble DNP-BSA could not. In addition to mouse mast cells, PCLF formed rosettes with rat basophil leukemia cells, mouse peritoneal exudate macrophages, mouse alveolar macrophages, and J 774 cultured mouse macrophages; it did not form rosettes with rat mast cells, rat alveolar macrophages, or mouse spleen cells. Thus, PCLF-formed rosettes were antigen specific, relatively species specific, and mast cell/macrophage specific. PCLF-mediated rosette-forming activity could be detected in the presence of nanogram quantities of PCLF. More than 10 times greater IgE was needed to produce IgE-mediated rosettes. Reduction and alkylation eliminated the rosetting activity of IgE, but the rosetting activity of PCLF was not affected. PCLF, but not IgE rosette-forming activity, could be removed by and eluted from affinity columns linked with a monoclonal antibody specific for T cell-derived antigen-binding factors, whereas PCLF rosetting activity was not retained by an anti-immunoglobulin affinity column. Preincubation of mast cells with rat myeloma IgE or mouse monoclonal IgE of various specificities blocked IgE rosettes but not PCLF-induced rosettes. Other immunoglobulin isotypes likewise did not block PCLF rosettes. However, PCLF rosettes could be blocked by preincubation of mast cells with OX factor (OXF),and OXF-mediated rosettes could be blocked similarly by PCLF. These results suggest that the antigen-binding T cell factor PCLF interacts with a unique receptor on the surface of mouse mast cells.