gebhart/patrepeval huggingface dataset:
[Non-invasive quantitative evaluation of aortic regurgitation by ultrasonic pulsed Doppler flowmeter (author's transl)]. (1981)

A usefulness of non-invasive and quantitative evaluation of aortic regurgitation (AR) was investigated by measuring the aortic arch flow from the suprasternal notch with ultrasonic pulsed Doppler flowmeter (UPDF). Measurement of the blood flow was made on 19 patients with AR, calculating the regurgitant ratio from the waves of relative flow volume, and the estimated grade of AR was compared with the severity judged from the cineaortogram. The results were as follows: 1) The aortic arch flow was recorded in 17 out of 19 patients with AR. 2) Except mild cases, the diastolic regurgitant flow was recorded in patients with AR. 3) The regurgitant ratio obtained by the UPDF correlated well with the grade of the severity of AR judged from the cineaortogram.
MRI parallel processing for embedded visualization (2013)

This work focuses on the development of the BrainTool, an embedded application that provides full automated volume segmentation and visualization of a reconstructed 3D mesh of human brains. A brain scan is performed to acquire a set of voxels using a 3D Magnetic Resonance sampler. The application is executed on embedded (mobile) systems. The tool operates through three principal modules: an automatic segmentation to remove the non-brain structures, a parallel implementation state of art Marching Cubes mesh synthesizer followed by an OpenGL ES rendering step to achieve model interactive visualization. The development of the application is done using two different low cost boards integrating low power state of art CPU and GPU into embedded system on chip; in order to test the solution, samples acquired from MRI equipment commonly available at hospitals are used. The experiments allow to conclude that the Marching Cube algorithm parallelize fairly enough and can be distributed on the available resources reaching scalable performances when executed on laptop and embedded systems. Rendering of complex graphics assets up to 2.7M triangles per model is performed.
The relationship between a diagnosis of antisocial personality and hostility: Development of an antisocial hostility scale (1990)

An antisocial hostility scale was developed by correlating items of the Buss-Durkee Hostility Inventory with a diagnosis of antisocial personality (ASP) as determined by a computerized version of the DSM-III. Fifty-two male volunteers for drug-related studies at the Addiction Research Center were used for a preliminary test development sample. The scale developed thereby was related significantly to a diagnosis of antisocial personality in a cross-validation sample of 28 drug abusers. A final scale was developed by obtaining correlations between ASP and Buss-Durkee items using the subjects from both of these preliminary samples. Items that comprise the scale were predominantly behaviorally oriented hostility items covered by the Assault scale rather than affective items such as those in the Resentment scale. In a 122 cross-validation sample the scale was related significantly to a diagnosis of antisocial personality. The study confirms the generality of the criterion of overt aggression as a condition for meeting DSM-III criteria for antisocial personality.
A simple spectral solar irradiance model for cloudless maritime atmospheres (1990)

A simple spectral atmospheric radiative transfer model specific for oceanographic applications begins with spectral extraterrestrial solar irradiance corrected for earth‐sun orbital distance. Irradiance is then attenuated in passing through the atmosphere by Rayleigh scattering, ozone, oxygen, and water vapor absorption, and marine aerosol scattering and absorption, and is finally reduced by reflectance at the air‐sea interface. The model is an extension of the continental aerosol model of Bird and Riordan, modified to include maritime aerosol properties, irradiance transmittance through the air‐sea interface, and atmospheric absorption at very high spectral resolution (1 nm). Atmospheric optical constituents and the surface reflectance are functions of the local meteorological conditions, imparting flexibility to the model to reproduce the spectral irradiance under a variety of maritime atmospheres. The model computes irradiance at or just below the ocean surface at high spectral resolution in the range 350–700 nm, i.e. within the range required for photosynthetically available radiation (PAR) calculations. It agrees spectrally with observed surface spectral irradiances to within ±6.6% (rms) and as integrated PAR to within ±5.1%. The computed spectral irradiance is useful as an input to bio‐optical models in the ocean, to phytoplankton growth and primary production models, and in remote‐sensing applications.
Anti-tumor necrosis factor α therapy associates to type 17 helper T lymphocytes immunological shift and significant microbial changes in dextran sodium sulphate colitis (2019)

Anti-TNFα treatment in experimental model of colitis improves disease activity but it is associated to an increase in Th17 pathway together with gut microbiota alteration.
Identification of Human Lung and Skin Proteins Conjugated with Hexamethylene Diisocyanate in Vitro and in Vivo (2000)

Diisocyanates are asthma-causing chemicals used in the commercial production of polyurethane. We have previously shown that human lung epithelial cell proteins can become conjugated with hexamethylene diisocyanate (HDI) and may be biologically important in diisocyanate-induced asthma. The objective of this study was to identify specific human lung and skin proteins that become conjugated with diisocyanate after in vitro and in vivo exposure. Following in vitro exposure of human airway epithelial cells (A549), keratin 18, the 78-kD glucose-regulated protein, trans-1, 2-dihyrobenzene-1,2-diol dehydrogenase, and actin were identified as prominent diisocyanate-conjugated proteins through use of a combination of immunocytochemical and mass spectrometric techniques. Following in vivo inhalation of an HDI aerosol, keratin 18 was also identified as the predominant diisocyanate-conjugated protein in human endobronchial biopsy samples, whereas albumin was the predominant diisocyanate-conjugated protein in bronchoalveolar lavage fluid. Keratin was also identified as a predominant diisocyanate-conjugated protein in human skin biopsy samples after epicutaneous exposure to liquid-phase HDI, although the major skin diisocyanate-conjugated protein (56-kD) differed from the predominant lung diisocyanate-conjugated keratin (47-kD). The data from this study identify keratin and other proteins as potential "carriers" for diisocyanates in vivo, and suggest that HDI conjugation of these proteins may play a role in the pathogenesis of diisocyanate-induced asthma.
Conformations and Barriers of Haloethyl Radicals (CH2XCH2, X = F, Cl, Br, I):  Ab Initio Studies (1999)

Radicals such as CH2XCH2•, where X is a halogen, play an important role in the stereochemical control observed in many chemical reactions. To elucidate the origin of the stereoselectivity, we calculated the structures and potential energy surfaces of the haloethyl radicals (CH2XCH2•, X = F, Cl, Br, I) using ab initio quantum mechanics [HF, local MP2, DFT (both B3PW91 and B3LYP)]. We find that the CH2BrCH2• and CH2ICH2• radicals strongly favor the symmetrically bridged structures while the CH2ClCH2• radical leads to similar energy for symmetric bridging and classical structures. (In contrast, X = H and F leads to dramatically different structures). This confirms the Skell hypothesis of symmetric bridging to explain the stereochemical control of the CH2BrCH2• and CH2ICH2• radicals, indicating that such bridged structures play an important role in the dissociation processes involving CH2XCH2• with X = Cl, Br, and I. The trends in the rotational barriers and structural parameters are consistent with hyperconjugation between the singly occupied carbon 2p orbital and the σ*(C-X) MO. We find that the rotational barrier, bridged structure, and dissociation of the radicals are described much more accurately using DFT (with GGA) than with HF or LMP2.
Nucleologenesis: use of non‐isotopic in situ hybridization and immunocytochemistry to compare the localization of rDNA and nucleolar proteins during mitosis (1989)

Using in situ hybridization and immunocytochemistry during interphase and mitosis, we have compared the distribution of ribosomal DNA (rDNA) to that of the nucleolar proteins fibrillarin and RNA polymerase I. During interphase, nucleolar proteins were localized at sites throughout the nucleolus while the bulk of rDNA was localized in a single restricted nucleolar area. During metaphase and anaphase, all six NORs were detected by in situ hybridization, Ag-staining, or by the immunolocalization of RNA polymerase I. During telophase, rDNA and RNA polymerase I were found in a distinct subset of the prenucleolar bodies (PNBs) which obviously must contain the nucleolar organizers. Other numerous PNBs are smaller in size and do not contain detectable amounts of rDNA or RNA polymerase I. Therefore, reconstruction of the nucleolus originates in telophase-specific domains which contain both rDNA and RNA polymerase I.
Exon 5 and Spermine Regulate Deactivation of NMDA Receptor Subtypes (2000)

Deactivation of N-methyl-D-aspartate (NMDA) channels after brief agonist exposure determines the duration of their synaptic activation during excitatory neurotransmission. We performed patch-clamp recordings of L-glutamate responses from human embryonic kidney tumoral cells (HEK293) expressing NR1 subunit variants lacking exon 5 together with the NR2B subunit. These responses had deactivation components that lasted several seconds. The presence of exon 5 or spermine greatly accelerated deactivation of L-glutamate responses through alterations in desensitization. These effects were also observed at positive holding potentials and in the presence of physiological Mg(2+). Thus NR1 splicing and polyamines may have profound effects on the kinetics of NMDA receptor-mediated synaptic transmission.
Band power envelope analysis-a new method in quantitative EEG (2002)

An original method of quantitative electroencephalography (EEG) is presented. In addition to standard frequency analysis, the authors analyze Band Power Envelope (BPE) of basic EEG frequency bands (delta, theta, alpha and beta). Proposed method introduces new parameters: periodicity and stability of frequency in EEG band. The method is applied in analysis of brain wave activities during altered state of consciousness related to healing process, in comparison with normal state. The authors have found the most prominent changes at lower frequencies (delta and theta bands).
Comparison of 4 Blood Storage Methods in a Protocol for Equine Pre‐operative Autologous Donation (2004)

Commercial CPDA-1 bags appear to be the optimal storage method for equine whole blood.
Activating a [FeFe] Hydrogenase Mimic for Hydrogen Evolution under Visible Light** (2022)

Inspired by the active center of the natural [FeFe] hydrogenases, we designed a compact and precious metal-free photosensitizer-catalyst dyad (PS-CAT) for photocatalytic hydrogen evolution under visible light irradiation. PS-CAT represents a prototype dyad comprising π-conjugated oligothiophenes as light absorbers. PS-CAT and its interaction with the sacrificial donor 1,3-dimethyl-2-phenylbenzimidazoline were studied by steady-state and time-resolved spectroscopy coupled with electrochemical techniques and visible light-driven photocatalytic investigations. Operando EPR spectroscopy revealed the formation of an active [Fe<sup>I</sup> Fe<sup>0</sup> ] species-in accordance with theoretical calculations-presumably driving photocatalysis effectively (TON≈210).
Supplementary Figures 1-8, Tables 1-9 from Functional Viability Profiles of Breast Cancer (2023)

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On Confidence Intervals for the Coherence Function (2006)

We address the problem of confidence interval estimation for the coherence function. We revisit a recently proposed approach to calculate confidence intervals from the asymptotic distribution function of the sample coherence function. We then propose a bootstrap based approach and compare the level of confidence obtained by the two methods as well as a well-established method proposed by Enochson and Goodman (1965). Extensive simulations have shown that the bootstrap approach is more accurate, in particular for a large coherence and non-Gaussian data.
Development of an immunoassay to measure the absorption of dietary furanocoumarins in humans (1996)

Conference Article| August 01 1996 Development of an immunoassay to measure the absorption of dietary furanocoumarins in humans PAUL I. CREEKE; PAUL I. CREEKE 1Food Molecular Biochemistry Department, Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK Search for other works by this author on: This Site PubMed Google Scholar MARIA P. CAMÁÑEZ GINESTAR; MARIA P. CAMÁÑEZ GINESTAR 1Food Molecular Biochemistry Department, Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK Search for other works by this author on: This Site PubMed Google Scholar HEATHER A. LEE; HEATHER A. LEE 1Food Molecular Biochemistry Department, Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK Search for other works by this author on: This Site PubMed Google Scholar MICHAEL R. A. MORGAN; MICHAEL R. A. MORGAN 1Food Molecular Biochemistry Department, Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK Search for other works by this author on: This Site PubMed Google Scholar KEITH R. PRICE; KEITH R. PRICE 1Food Molecular Biochemistry Department, Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK Search for other works by this author on: This Site PubMed Google Scholar MICHAEL J. C. RHODES; MICHAEL J. C. RHODES 1Food Molecular Biochemistry Department, Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK Search for other works by this author on: This Site PubMed Google Scholar ANDREW P. WILKINSON ANDREW P. WILKINSON 1Food Molecular Biochemistry Department, Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1996) 24 (3): 394S. https://doi.org/10.1042/bst024394s Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation PAUL I. CREEKE, MARIA P. CAMÁÑEZ GINESTAR, HEATHER A. LEE, MICHAEL R. A. MORGAN, KEITH R. PRICE, MICHAEL J. C. RHODES, ANDREW P. WILKINSON; Development of an immunoassay to measure the absorption of dietary furanocoumarins in humans. Biochem Soc Trans 1 August 1996; 24 (3): 394S. doi: https://doi.org/10.1042/bst024394s Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1996 Biochemical Society1996 Article PDF first page preview Close Modal You do not currently have access to this content.
Introduction (2014)

This chapter introduces ultra-high temperature ceramics. The first section provides background information about the conference that motivated this compilation. Next, Ultra-High temperature ceramics are described and applications for these materials are listed. The chapter concludes by previewing the content of the rest of the book.
Ethanol and Natural Killer Cells. II. Stimulation of Human Natural Killer Activity by Ethanol In Vitro (1997)

A single ethanol ingestion of 1 g/kg by healthy individuals under controlled conditions does not inhibit and may stimulate fresh natural killer (NK) activity measured 16 hr later. However, ethanol inhibits fresh human NK activity when added to the lytic assay medium, as reported previously by other investigators. In contrast, using the same target (K562 erythroleukemia cells), peripheral blood mononuclear cells cultured 3 days with 50 units/ml of interleukin-2 are no longer inhibited significantly by the same concentration of ethanol that inhibited the fresh cells by 80%. When freshly isolated peripheral blood mononuclear cells, monocyte-depleted lymphocytes, or partially purified NK cells are pre-exposed to ethanol in vitro for 1 to 7 days, washed, and assayed for lytic activity against K562, the lytic activity is increased compared with nonethanol-exposed cells incubated concurrently. This increase is not dependent on accessory cells, added cytokines, or cell growth, and seems to be an intrinsic response of the NK subset to ethanol exposure. The finding of NK stimulation by ethanol, considered together with the observation of NK cell loss in some chronic alcoholics, suggests that loss of NK activity in the chronic alcoholic may result from cell loss rather than direct ethanol inhibition of NK activity.
Chronic Estrogen Treatment Promotes a Functional Uncoupling of the D2Dopamine Receptor in Rat Anterior Pituitary Gland (1989)

The effect of chronic estrogen treatment on the anterior pituitary D2 dopamine receptor was studied by treating rats with diethylstilbestrol (DES) over a 6-week period. DES treatment resulted in an increase in anterior pituitary weight and PRL content and serum PRL levels compared to those in sham-treated controls. The status of the anterior pituitary D2 dopamine receptor was evaluated using both radioligand binding and adenylate cyclase assays. [125I]N-(p-aminophenethyl)spiroperidol [( 125I]NAPS), a derivative of the D2-selective antagonist spiperone, was used to quantitate D2 receptors. Saturation analysis of [125I]NAPS binding indicated that DES treatment had no effect on the affinity or maximum binding capacity of the radioligand for the D2 receptor. Competition analysis with unlabeled D2 antagonists for [125I]NAPS binding also indicated that DES treatment did not affect antagonist interactions with the receptor. In contrast, the interactions of agonists with the D2 receptors from DES-treated rats were modified, as assessed through [125I]NAPS competition analysis. Using control tissue, agonist competition curves revealed both high and low affinity agonist binding states of the receptor. In the presence of guanine nucleotides, the high affinity agonist binding state is abolished, reflecting coupling of the receptor with a guanine nucleotide regulatory (G) protein. In DES-treated tissue, agonist competition curves indicated the presence of only low affinity agonist binding, with minimal effects of guanine nucleotides, suggesting uncoupling of receptor-G-protein interactions. The functionality of the D2 receptor was further assessed by examining dopaminergic inhibition of vasoactive intestinal peptide-stimulated adenylate cyclase activity. Although DES treatment resulted in a reduction of vasoactive intestinal peptide-stimulated enzyme activity itself, the ability of dopaminergic agonists to inhibit this activity was reduced by about 50%. These results suggest that estrogen is capable of attenuating the functional coupling of the D2 receptor with its biochemical effector system in the anterior pituitary gland.
An Exploration of Spatial Radiomic Features in Pulmonary Sarcoidosis (2018)

Sarcoidosis is a rare, multi-systemic, inflammatory disease, primarily affecting the lungs. High-resolution computed tomography (CT) scans are used to clinically characterize pulmonary sarcoidosis. In the medical imaging field, there is growing recognition to switch from visual examination of CT images to more rapid, objective assessments of the abnormalities. In this work, we explore the usefulness of various objective measures of spatial heterogeneity---fractal dimension, Moran's I, and Geary's C ---for distinguishing between abnormal sarcoidosis and normal lung parenchyma. CT data for N=58 sarcoidosis subjects enrolled at National Jewish Health were obtained from the GRADS study. CT data for N=101 control patients were obtained from the COPDGene study. Radiomic measures were computed for each two-dimensional slice of a given scan, in the axial, coronal, and sagittal planes. Functional regression was applied to identify lung regions where CT nodules tend to proliferate. Moran's I, Geary's C and fractal dimension significantly differentiate between subjects with and without sarcoidosis throughout the majority of the lung, with disease abnormalities most apparent in the top axial, middle coronal, and outer sagittal regions. A trend appeared across Scadding stages, with CT scans from patients with Scadding stages I and III appearing the healthiest, and Scadding stage IV appearing the least healthy. The radiomic measures and techniques presented herein successfully characterize CT images in sarcoidosis by objectively and efficiently approximating what we know about the pathology of sarcoidosis.
Effects of Linear versus Sigmoid Coding of Visual or Audio Biofeedback for the Control of Upright Stance (2006)

Although both visual and audio biofeedback (BF) systems for postural control can reduce sway during stance, a direct comparison between the two systems has never been done. Further, comparing different coding designs of audio and visual BF may help in elucidating how BF information is integrated in the control of posture, and may improve knowledge for the design of innovative BF systems for postural control. The purpose of this paper is to compare the effects of linear versus sigmoid coding of trunk acceleration for audio and visual BF on postural sway in a group of eight, healthy subjects while standing on a foam surface. Results showed that sigmoid-coded audio BF reduced sway acceleration more than did a linear-coded audio BF, whereas a linear-coded visual BF reduced sway acceleration more than a sigmoid-coded visual BF. In addition, audio BF had larger effects on reducing center of pressure (COP) displacement whereas visual BF had larger effects on reducing trunk sway. These results suggest that audio and visual BF for postural control benefit from different types of sensory coding and each type of BF may encourage a different type of postural sway strategy.
Receptors and Transduction Mechanisms I: Receptors Coupled Directly to Ion Channels (2015)

The common feature that allows neurons and other cells to respond to extracellular signals is the presence of specific receptors in the plasma membrane, which may be similar in their structure and functional properties in different kinds of cells. There may be several different kinds of receptors for individual neurotransmitters. Many receptors can be grouped into families based on structural, functional, and regulatory homologies that are far more extensive than had been appreciated previously. One such family is that of the ligand-gated ion channels, whose members were first linked on the basis of a functional criterion—direct coupling between the receptor and the ion channel whose activity it regulates. Evolution has allowed the ligand specificity of the receptor site and the ion selectivity of the channel pore to diverge. However, the essential overall structural design of the ligand-gated receptor–channel complex has been preserved.