gebhart/patrepeval huggingface dataset:
Hyperspectral polarized light scattering to study tumor cells in in-vitro samples (2012)

Supercontinuum laser sources provide a very useful tool to characterize materials and scattering media such as nanomaterials in suspensions, aerosols or paint coatings. Onera, The French Aerospace Lab, has developed a fast, in-line and comprehensive optical characterization method. The hyperspectral polarized angular light measurements by tumor cells exhibit a unique signature. We propose an original way to probe tumor cells in in-vitro samples. First experimental results are presented with potential applications. This is the first time in our knowledge that hyperspectral, polarimetric and angular signature of MCTS is reported.
The Influence of Ionic Strength and Incubation Time on theSensitivity of Methods Using Papainized Red Cells (1979)

The sensitivity of a combination of various papain methods with normal and low ionic strength (lis) of the serum-cell mixture for the detection of red cell antibodies was tested after varying periods of incubation of the mixture. The mixture was centrifuged before reading when the period of incubation was short. The maximum sensitivity without centrifugation was always reached after a period of 60 min. With a longer incubation the sensitivity decreased. A sensitivity that equalled the maximum sensitivity without centrifugation could be obtained after only 10 min of incubation, if it was followed by a centrifugation before reading. Lis consistently increased the sensitivity of the papain methods, especially after 45-60 min of incubation.
Conversion of Milled Pine Wood by Manganese Peroxidase from Phlebia radiata (2001)

Purified manganese peroxidase (MnP) from the white-rot basidiomycete Phlebia radiata was found to convert in vitro milled pine wood (MPW) suspended in an aqueous reaction solution containing Tween 20, Mn(2+), Mn-chelating organic acid (malonate), and a hydrogen peroxide-generating system (glucose-glucose oxidase). The enzymatic attack resulted in the polymerization of lower-molecular-mass, soluble wood components and in the partial depolymerization of the insoluble bulk of pine wood, as demonstrated by high-performance size exclusion chromatography (HPSEC). The surfactant Tween 80 containing unsaturated fatty acid residues promoted the disintegration of bulk MPW. HPSEC showed that the depolymerization yielded preferentially lignocellulose fragments with a predominant molecular mass of ca. 0.5 kDa. MnP from P. radiata (MnP3) turned out to be a stable enzyme remaining active for 2 days even at 37 degrees C with vigorous stirring, and 65 and 35% of the activity applied was retained in Tween 20 and Tween 80 reaction mixtures, respectively. In the course of reactions, major part of the Mn-chelator malonate was decomposed (85 to 87%), resulting in an increase of pH from 4.4 to >6.5. An aromatic nonphenolic lignin structure (beta-O-4 dimer), which is normally not attacked by MnP, was oxidizible in the presence of pine wood meal. This finding indicates that certain wood components may promote the degradative activities of MnP in a way similar to that promoted by Tween 80, unsaturated fatty acids, or thiols.
Comparison between BAW and SAW sensor principles (2002)

A comparison between piezoelectrically excited Bulk Acoustic Wave (BAW) and Surface Acoustic Wave (SAW) elements with respect to their primary sensitivity functions and principal capabilities for sensor applications is given. The importance of mode-purity for high dynamic range sensors is emphasized. Characteristic sensor examples are reviewed and the special demands on the electronics for BAW and SAW elements in the sensor field are described (e.g. cable problem, wireless SAW sensors). For a fair evaluation a performance figure SQ, defined as the product of reduced sensitivity S and resonator Q-value, is introduced. Finally, the potential of alternative piezoelectric materials for future sensor developments is briefly discussed.
SIZE MEASUREMENT AND CHARACTERISATION OF WELD DEFECTS BY ULTRASONIC TESTING (1979)

Reports from the fabrication industry on the misinterpretation of defects with conventional manual ultrasonic testing have been widespread. Over-estimation of defects has resulted in unnecessary, expensive and time consuming repair and under-estimation may have led to significant defects being allowed into service. This paper reports on a program to define the problem by studying the interaction of ultrasound with weld defects using conventional equipment and assessment techniques, and to establish how the more recently developed and sophisticated techniques can be used to advantage. The present collaborative program of work is aimed to quantifying ultrasonic testing capability by providing detailed information on the application of both conventional and more specialized ultrasonic techniques to a large sample of defects and features in ferritic steel weldments in the 38 to 95mm thickness range.
Ibrutinib Plus Venetoclax for First-line Treatment of Chronic Lymphocytic Leukemia (2021)

ClinicalTrials.gov Identifier: NCT02756897.
Synthèse d'analogues de l'ATP, ligands des récepteurs P2Y (2004)

info:eu-repo/semantics/nonPublished
Antibody-nucleic acid interactions. Antibodies to psoralen-modified RNA as probes of RNA structure (1987)

Antisera elicited by immunization of rabbits with 4'-aminomethyl-trioxsalen (AMT)-modified poly(A,U) complexed with methylated bovine serum albumin was characterized in competition radioimmunoassays (RIA) and enzyme-linked immunosorbent assays (ELISA). AMT-poly(A,U) was over 10,000-fold more reactive than unmodified poly(A,U) or AMT alone. The antiserum cross-reacted to varying extents with AMT-modified-RNA's and -DNA's. The presence of AMT-uridine usually assured strong reactivity. The amino group of AMT contributed to antibody binding to a small degree. Binding was not significantly affected by high ionic strength, suggesting that binding does not involve ion pair formation. Murine encephalomyocarditis virus replicative intermediates, as well as cellular RNA and DNA were modified by psoralen in intact cells, suggesting that EMCV RNA and cellular RNA's in intact cells possess detectable stretches of base pairs. The antibodies described here will be useful in studying the secondary and tertiary structure of RNA's in vitro and in intact cells.
Topical Application of BMS-509744, a Selective Inhibitor of Interleukin-2-Inducible T Cell Kinase, Ameliorates Imiquimod-Induced Skin Inflammation in Mice (2021)

Psoriasis is an immune disorder-related inflammatory skin disease. Recent studies have suggested a contribution of T cell activation in the pathogenesis of psoriasis. Interleukin-2 (IL-2)-inducible T cell kinase (ITK) regulates T cell activation, including proliferation, and cytokine production. In this study, we investigated the effect of the topically administered selective ITK inhibitor BMS-509744 on imiquimod (IMQ)-induced psoriasis-like skin inflammation in mice. Topically administered BMS-509744 ameliorated IMQ-induced psoriasis-like skin inflammation as shown by decreased skin lesions, epidermal thickening, and cell infiltration into the dermis. These suppressive effects occurred with lower numbers of cluster of differentiation antigen-3<sup>+</sup> (CD3<sup>+</sup>) T cells and T helper subset 17 (Th17)-related cytokine expression in IMQ-treated skin. IMQ-induced upregulation of proinflammatory cytokine expression was also inhibited by topical application of BMS-509744 in IMQ-treated skin. Our report showed for the first time that topical application of BMS-509744 ameliorated psoriasis-like skin inflammation in mice, which is likely mediated by the inhibition of T cell activation in the skin lesions.
Custom Fabricated High-Q Analog Dual-Gap RF MEMS Varactors (2006)

An RF MEMS capacitor design, fabrication and measurement is described. The capacitor's dual gap height architecture allows for continuous electrostatic tuning with low resistive loss and a large tuning range. Two voltage sources are used to reach the full tuning potential of the device. Measurements indicate a capacitance tuning range of 6.2:1 with a quality factor over 50 at 30 GHz for 310 fF.
Peircean Semiotics and Text Linguistic Models (2010)

Figure 24Semiotic triads dissolve a sign into three forming parts, which can maximally facilitate our understanding of how metaphors are constructed.Semiotic triads dissolve a sign into three forming pans, which can maximally facilitate our understanding of how individual signs are related to each other.how the contrast between individual signs serves to explain the topological correspondence between the source concept and the target, how metaphors of different dimentions cohere or fail to cohere, and how unconventional signs deviate from conventional metaphor and, as a consequence.coherence fails. References
Simple Catadioptric Magnifiers (1983)

The present paper describes the basic principles and the geometries of certain simple catadioptric magnifiers that have been designed and fabricated. These magnifiers are made of moderately curved spherical surfaces and are capable of producing high visual magnifications with large eye-relief. Such magnifiers are found to be useful for reading microfiche having nominal frame sizes of 16mm X 12mm and 12mm X 9mm.
On Point-Based Haptic Rendering (2013)

Haptic rendering is referred to as an approach for complementing graphical model of the virtual object with mechanics- based properties. As a result, when the user interacts with the virtual object through a haptic device, the object can graphically deflect or deform following laws of mechanics. In addition, the user is able to feel the resulting interaction force when interacting with the virtual object. This paper presents a study of defining the levels-of-detail (LOD) in point-based computational mechanics for haptic rendering of objects. The approach uses the description of object as a set of sampled points. In comparison with the finite element method (FEM), point-based approach does not rely on any predefined mesh representation and depends on the point representation of the volume of the object. Different from solving the governing equations of motion representing the entire object based on pre-defined mesh representation which is used in FEM, in point-based modeling approach, the number of points involved in the computation of displacement/deformation can be adaptively defined during the solution cycle. This frame work can offer the implementation of the notion for levels-of-detail techniques for which can be used to tune the haptic rendering environment for in- creased realism and computational efficiency. This paper presents some initial experimental studies in implementing LOD in such environment.
5. Evaluation of Speech Translation Systems (2010)

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Alemtuzumab outcomes over 6 years in RRMS patients who switched from SC IFNB-1a: follow-up of CARE-MS I patients (TOPAZ study) (2018)

Aims: Evaluate efficacy and safety of alemtuzumab over 6 y in patients who initiated alemtuzumab after receiving SC IFNB-1a in CARE-MS I.\n\nMethods: At investigator discretion, patients in TOPAZ can receive additional as-needed alemtuzumab (≥12 months apart; no criteria), or receive another DMT (at any time). MRI disease activity was defined as new gadolinium (Gd)-enhancing or new/enlarging T2 hyperintense lesions.\n\nResults: Of 139 patients initiating alemtuzumab in the extension, 117 (84%) completed Y2 of TOPAZ (Y6 after initiating alemtuzumab); 67% received neither additional courses of alemtuzumab nor another DMT. At Y6, the annualised relapse rate was 0.19, and 70% of patients had stable/improved EDSS scores from CARE-MS I baseline. After initiating alemtuzumab, 69% were free from 6-month confirmed disability worsening and 28% had 6-month confirmed disability improvement. At Y6, 62% were free of MRI disease activity, 82% were free of new Gd-enhancing lesions, and 62% were free of new/enlarging T2 hyperintense lesions. Median percent cumulative brain volume loss (BVL) from CARE-MS I baseline was -1.99% over 8 total study y; -1.49% occurred over Y0-2 with SC IFNB-1a, and -0.23% occurred over 6 y with alemtuzumab. Safety was consistent with the alemtuzumab arm of the core and extension studies.\n\nConclusions: Alemtuzumab improved clinical, MRI, and BVL outcomes in patients who initiated alemtuzumab after receiving SC IFNB-1a in CARE-MS I. These improved outcomes were maintained over 6 y in the absence of continuous treatment, with a consistent safety profile that is manageable and acceptable.
Dopant Electromigration in Semiconductors (1997)

Abstract A doped semiconductor can be viewed as a mixed electronic‐ionic conductor, with the dopants as mobile ions. Normally the temperature range where this becomes true is not even close to that where the (opto)electronic properties of the material are of interest. However, notable exceptions exist and these are reviewed here, with special emphasis on those cases where semiconductivity is preserved when the (mobile) dopant concentration changes and ambipolar behavior can be obtained by dopant mobility. Dopant diffusion and drift are of interest not only in materials such as Si:Li, known from its use in radiation detectors, but also in other semiconductors, ranging from II‐VIs and related compounds, such as (Hg,Cd)Te and CuInSe 2 to III‐Vs and potential high temperature semiconductors, such as diamond. Better understanding of the phenomena is important also because of the implications that it has for device miniaturization, as dopant diffusion and drift put chemical limits to device stability. Such understanding can also make dopant electromigration useful for low‐temperature doping. Some basic theory for electric‐field‐induced dopant migration is given and compared to experiments.
Slew-rate limited envelopes for driving envelope tracking amplifiers (2011)

This paper presents a practical application of a method for generating slew-rate limited envelopes in order to drive the dynamic supply of envelope tracking (ET) power amplifiers (PAs). The proposed method results useful to generate slower versions of the transmitted signal's envelope to cope with the slew-rate and bandwidth limitations of envelope amplifiers. Moreover, this paper shows experimental results comparing the performance of ET when exciting the drain of a PA (based in a GaN transistor) with both the envelope of the signal and the slew-rate limited version of the envelope.
Lipopolysaccharide stimulation of 70 kilo Dalton heat shock protein messenger ribonucleic acid production in cultured human fetal membranes (2001)

Human fetal membranes constitutively express heat shock protein 70 messenger ribonucleic acid. Bacterial lipopolysaccharide markedly stimulated heat shock protein 70 messenger RNA gene transcription in human fetal membranes. Thus, heat shock protein 70 is inducible in fetal membranes and may facilitate fetal survival under adverse conditions.
Performance Analysis of Heterogeneous Feedback Design in an OFDMA Downlink With Partial and Imperfect Feedback (2012)

Current OFDMA systems group resource blocks into subband to form the basic feedback unit. Homogeneous feedback design with a common subband size is not aware of the heterogeneous channel statistics among users. Under a general correlated channel model, we demonstrate the gain of matching the subband size to the underlying channel statistics motivating heterogeneous feedback design with different subband sizes and feedback resources across clusters of users. Employing the best-M partial feedback strategy, users with smaller subband size would convey more partial feedback to match the frequency selectivity. In order to develop an analytical framework to investigate the impact of partial feedback and potential imperfections, we leverage the multi-cluster subband fading model. The perfect feedback scenario is thoroughly analyzed, and the closed form expression for the average sum rate is derived for the heterogeneous partial feedback system. We proceed to examine the effect of imperfections due to channel estimation error and feedback delay, which leads to additional consideration of system outage. Two transmission strategies: the fix rate and the variable rate, are considered for the outage analysis. We also investigate how to adapt to the imperfections in order to maximize the average goodput under heterogeneous partial feedback.
Electronic supplementary material, video, Movie S1 (2017)

Animal-borne-video footage showing the foraging behaviour of African penguins including an elevated school event, targeting of depolarised fish, group foraging and a bait-ball event.
Selective Molecularly Imprinted Polymer Obtained from a Combinatorial Library for the Extraction of Bisphenol A (2006)

In the present work, an analytical methodology based on molecularly imprinted solid-phase extraction (MISPE) has been developed for the determination of bisphenol A (BPA) in environmental and food samples. In order to select the optimum material, a combinatorial library of molecularly imprinted polymers in small-scale (mini-MIPs) was prepared using BPA as template. Different monomers (methacrylic acid or 4-vinylpyridine), crosslinkers (ethylene glycol dimethacrylate or trimethylolpropane trimethacrylate) and porogens (methanol, acetonitrile or toluene) were used leading to 24 different polymerisation mixtures. After BPA removal, the ability of mini-MIPs to recognise BPA was evaluated by equilibrium rebinding-elution experiments. The copolymer of 4-vinylpyridine (4-VP) and trimethylolpropane trimethacrylate (TRIM) prepared in toluene showed the higher affinity for the template. Subsequently, a scaled-up version of the optimum polymer was prepared and used in the development of MISPE procedures for the extraction of BPA. The optimised MISPE protocols were successfully applied to the selective extraction of BPA from soils and aqueous canned peas samples.
Thermodynamic Properties of 1-Propyl-3-methylimidazolium Glutamic Acid Salt (2010)

Molar heat capacities (Cp,m) of the room-temperature ionic liquid (IL) 1-propyl-3-methylimidazolium glutamic acid salt ([C3mim][Glu]) were measured with a high-precision automated adiabatic calorimeter (AC) in the temperature range of T = (85 to 360) K. A glass transition was observed at 239.861 K. The enthalpy and entropy of the glass transition were determined to be 2.87 kJ·mol−1 and 11.97 J·K−1·mol−1, respectively. Two polynomial equations of molar heat capacity as a function of the temperature were fitted before and after the glass transition. The thermodynamic functions (HT − H298.15) and (ST − S298.15) were derived from the molar heat capacity data in the temperature range of T = (85 to 360) K with an interval of 5 K.
A Novel Micro Ring Structured PPy/pTS Free Standing Film With Improved Actuation Stability (2014)

A free-standing PPy/pTS film with a novel micro ring structured surface morphology have been electropolymerized by using CTAB/SDBS catanionic vesicles as templates. Characterizations showed that the micro ring structured PPy/pTS film was chemically similar to typical PPy/pTS films, while some DBS anions were also incorporated into the film from the mixed surfactants solutions. The micro ring structured PPy/pTS showed a slightly lower conductivity than conventional PPy/pTS films, due to the incorporation of DBS anions. The micro ring structured PPy/pTS films showed improved actuation stability compared to the conventional PPy/pTS films.
Awareness of performance on outcomes after total hip and knee arthroplasty among Dutch orthopedic surgeons: how to improve feedback from arthroplasty registries (2020)

Background and purpose - The Netherlands Registry of Orthopedic Implants (LROI) uses audit and feedback (A&F) as the strategy to improve performance outcomes after total hip and knee arthroplasty (THA/TKA). Effectiveness of A&F depends on awareness of below-average performance to initiate improvement activities. We explored the awareness of Dutch orthopedic surgeons regarding their performance on outcomes after THA/TKA and factors associated with this awareness.Methods - An anonymous questionnaire was sent to all 445 eligible Dutch orthopedic surgeons performing THA/TKA. To assess awareness on own surgeon-group performance, they were asked whether their 1-year THA/TKA revision rates over the past 2 years were below average (negative outlier), average (non-outlier), above average (positive outlier) in the funnel plot on the LROI dashboard, or did not know. Associations were determined with (1) dashboard login at least once a year (yes/no); (2) correct funnel-plot interpretation (yes/no) and; (3) recall of their 1-year THA/TKA revision rate (yes/no).Results - 44% of respondents started the questionnaire, 158 THA and 156 TKA surgeons. 55% of THA surgeons and 55% of TKA surgeons were aware of their performance. Surgeons aware of their performance more often logged in on the LROI dashboard, more often interpreted funnel plots correctly, and more often recalled their revision rate. 38% of THA and 26% of TKA surgeons scored "good" on all 3 outcomes.Interpretation - Only half of the orthopedic surgeons were aware of their performance status regarding outcomes after THA/TKA. This suggests that to increase awareness, orthopedic surgeons need to be actively motivated to look at the dashboard more frequently and educated on interpretation of funnel plots for audit and feedback to be effective.
Low crosstalk planar optical add-drop multiplexerfabricated with UV-induced Bragg gratings (1997)

The authors report the performance of an optical add-drop multiplexer made in silica-on-silicon waveguides by writing Bragg gratings in a Mach-Zehnder interferometer. The isolation between the add and the drop channels is better than 50 dB and the crosstalk between two adjacent channels is &lt; –27 dB.
DENSE sampling of features for image retrieval (2014)

This paper focuses on the image retrieval task. We propose the use of dense feature points computed on several color channels to improve the retrieval system. To validate our approach, an evaluation of various SIFT extraction strategies is performed. Detected SIFT are compared with dense SIFT. Dense color descriptors: C-SIFT and T-SIFT are then utilized. A comparison between standard and rotation invariant features is further achieved. Finally, several encoding strategies are studied: Bag of Visual Words (BOW), Fisher vectors, and vector of locally aggregated descriptors (VLAD). The presented approaches are evaluated on several datasets and we show a large improvement over the baseline.
Stratification of atopic dermatitis patients by patterns of response to proactive therapy with topical tacrolimus: low serum IgE levels and inadequately controlled disease activity at the start of treatment predict its failure (2021)

AD patients were stratified into three different response patterns to TCI proactive therapy. Patients with less involvement of IgE in the pathogenesis and inadequate remission induction by TCS may not be expected to respond well to TCI proactive therapy.Key messagesAD patients can be stratified into three types according to their pattern of responsiveness to TCI proactive therapy.The efficacy of TCI proactive therapy is lower in AD patients with lower serum IgE levels.TCI proactive therapy should be done after the achievement of adequate remission induction by TCS.