gebhart/patrepeval huggingface dataset:
Effects of estrogens and progestins on high density lipoproteins (1979)

Abstract High density lipoprotein (HDL) levels are known to be higher in women than in men, and to increase with estrogen use. To assess the effects of estrogens on HDL subspecies, analytic ultracentrifuge measurements of HDL were compared in 11 menopausal estrogen users and 16 controls. The difference in mean schlieren patterns between the groups showed a significantly higher level of HDL with flotation rate (F 1.20 o )&gt;1.5 (predominantly HDL 2 ) in the users. This was similar to the difference in HDL seen between nonusers of hormones and age‐matched males. A previous study had shown that users of combination oral contraceptives had increased levels of HDL with F 1.20 o ≤3.5 (primarily HDL 3 ) suggesting that the estrogen effect on HDL is altered by the presence of added progestin. The progrestin effect was studied here in more detail in two women with type V hyperlipoproteinemia treated with norethindrone acetate. Reduction in serum triglyceride was accompanied by a reduction in HDL, predominantly in the less dense species (HDL 2 ). Among groups of oral contraceptive and noncontraceptive estrogen and progestin users whose HDL‐cholesterol levels have been reported recently, there was a direct correlation (r=0.86, p&lt;.001) between mean HDL‐cholesterol and triglyceride levels. Endogenous hormonal influences on HDL were assessed by serum hormone and lipoprotein measurements at weekly intervals during two consecutive menstrual cycles in four healthy females. An increase in HDL of highest flotation rate (F 1.20 o 5–9) was seen, which corresponded with the time of ovulation raising the possibility of pituitary as well as gonadal hormone effects on HDL.
Output Mode Switching for Parallel Five-bar Manipulators Using a Graph-based Path Planner (2022)

The configuration manifolds of parallel manipulators exhibit more nonlinearity than serial manipulators. Qualitatively, they can be seen to possess extra folds. By projecting such manifolds onto spaces of engineering relevance, such as an output workspace or an input actuator space, these folds cast edges that exhibit nonsmooth behavior. For example, inside the global workspace bounds of a five-bar linkage appear several local workspace bounds that only constrain certain output modes of the mechanism. The presence of such boundaries, which manifest in both input and output projections, serve as a source of confusion when these projections are studied exclusively instead of the configuration manifold itself. Particularly, the design of nonsymmetric parallel manipulators has been confounded by the presence of exotic projections in their input and output spaces. In this paper, we represent the configuration space with a radius graph, then weight each edge by solving an optimization problem using homotopy continuation to quantify transmission quality. We then employ a graph path planner to approximate geodesics between configuration points that avoid regions of low transmission quality. Our methodology automatically generates paths capable of transitioning between non-neighboring output modes, a motion which involves osculating multiple workspace boundaries (local, global, or both). We apply our technique to two nonsymmetric five-bar examples that demonstrate how transmission properties and other characteristics of the workspace can be selected by switching output modes.
Complications of flexor tendon repair in the hand: MR imaging assessment. (1996)

MR imaging may enable distinction among several complications that occur after repair of an injured digital flexor tendon.
Cholesterol Removal from Homogenized Milk with β-Cyclodextrin (1999)

This study was carried out to determine optimum conditions of five different factors (beta-cyclodextrin concentration, mixing temperature, mixing time, centrifugal force, and centrifugation time) in reduction of cholesterol in 3.6% fat, homogenized milk by application of beta-cyclodextrin. beta-Cyclodextrin at 0.5 to 1.5% provided 92.2 to 95.3% removal of cholesterol when mixed at 10 degrees C for 10 min. Among other factors, mixing time (5 to 20 min) did not significantly affect cholesterol removal. Removal was enhanced with increasing centrifugal forces up to 166x g (95.9%) but decreased thereafter. Various centrifugation times (5 to 20 min) did not have significant effects. Based on these results, we suggest that the optimum conditions for the process are addition of 1.5% beta-cyclodextrin, mixing temperature of 10 degrees C, 10-min mixing time, and centrifugation at 166x g for 10 min.
Limited feedback precoding for spatial multiplexing systems using linear receivers (2004)

Multiple-input multiple-output (MIMO) spatial multiplexing wireless systems achieve high spectral efficiencies by demultiplexing the incoming bit stream into multiple substreams. Spatial multiplexing is of practical importance because the multiple substreams can be decoded using linear receivers. Unfortunately, this reduction in complexity degrades the probability of error performance. To overcome this difficulty, error rate performance of spatial multiplexing systems can be improved by sending fewer substreams than the number of transmit antennas by linear preceding. Criteria have been proposed for designing these precoders when complete channel knowledge is available to the transmitter. The assumption of complete channel knowledge is often unrealistic in many communication systems such as those with low rate feedback channels. Thus a quantized preceding scheme is proposed where the receiver sends back a fixed number of bits to the transmitter. This bit pattern corresponds to an index within a finite set of preceding matrices. A previously proposed criterion is used to determine the matrix in this precoder codebook to choose. A design method for these codebooks using techniques from Grassmannian subspace packing is presented. Simulation results show this technique outperforms typical antenna selection.
TheArabidopsis O-LinkedN-Acetylglucosamine Transferase SPINDLY Interacts with Class I TCPs to Facilitate Cytokinin Responses in Leaves and Flowers (2012)

O-linked N-acetylglucosamine (O-GlcNAc) modifications regulate the posttranslational fate of target proteins. The Arabidopsis thaliana O-GlcNAc transferase (OGT) SPINDLY (SPY) suppresses gibberellin signaling and promotes cytokinin (CK) responses by unknown mechanisms. Here, we present evidence that two closely related class I TCP transcription factors, TCP14 and TCP15, act with SPY to promote CK responses. TCP14 and TCP15 interacted with SPY in yeast two-hybrid and in vitro pull-down assays and were O-GlcNAc modified in Escherichia coli by the Arabidopsis OGT, SECRET AGENT. Overexpression of TCP14 severely affected plant development in a SPY-dependent manner and stimulated typical CK morphological responses, as well as the expression of the CK-regulated gene RESPONSE REGULATOR5. TCP14 also promoted the transcriptional activity of the CK-induced mitotic factor CYCLIN B1;2. Whereas TCP14-overexpressing plants were hypersensitive to CK, spy and tcp14 tcp15 double mutant leaves and flowers were hyposensitive to the hormone. Reducing CK levels by overexpressing CK OXIDASE/DEHYDROGENASE3 suppressed the TCP14 overexpression phenotypes, and this suppression was reversed when the plants were treated with exogenous CK. Taken together, we suggest that responses of leaves and flowers to CK are mediated by SPY-dependent TCP14 and TCP15 activities.
Structural and magnetic properties of Cu-doped ZnO epitaxial films at the coalescence limit—A superparamagnetic CuO-ZnO nanocomposite (2019)

A series of Cu-doped ZnO epitaxial films has been grown on sapphire substrates to investigate the possibilities of preparing a doped magnetic oxide at the coalescence limit. The growth was performed using reactive magnetron sputtering by varying the oxygen partial pressure to tune the incorporation of the Cu dopant and the resulting valence state. At low oxygen pressures, metallic Cu precipitates are formed, while at high oxygen partial pressures, the formation of CuO as a secondary phase could be evidenced. In-between, only a small fraction of the Cu can be substitutionally incorporated into the ZnO host matrix. The resulting magnetic properties are predominantly paramagnetic. However, the formation of the secondary CuO phase is accompanied by a small field imprinted magnetic component, which suggests that the CuO secondary phase consists of small and, thus, magnetically unblocked nanoprecipitates which are dispersed in the ZnO host matrix.
Health Information Exchange: A Novel Re-linkage Intervention in an Urban Health System (2019)

An HIE-informed, SW-led intervention systematically identified out-of-care PWH and may increase linkage to care for this important population. HIEs create an opportunity to intervene with linkage and retention strategies.
Single Dose Ofloxacin plus Loperamide Compared with Single Dose or Three Days of Ofloxacin in the Treatment of Traveler's Diarrhea (1997)

Background: Although the use of the antimicrobial, trimethoprim-sulfamethoxazole, in combination with the antisecretory and antimotility agent, loperamide, has been shown to be efficacious in the treatment of traveler's diarrhea, the use of fluoroquinolone antimicrobials in combination with loperamide has less support in the literature. The present study was designed to compare the efficacy of ofloxacin versus ofloxacin plus loperamide in the treatment of acute traveler's diarrhea. Method: This prospective, randomized, evaluator-blinded treatment trial was conducted in Guadalajara, Mexico, during the summers of 1992-1994. Adults newly arrived in Mexico from the United States who developed acute diarrhea of less than 2 weeks' duration were randomized to receive orally either: A) ofloxacin, 400 mg once; B) ofloxacin, 200 mg twice a day for six doses; or C) ofloxacin, 400 mg once, plus loperamide, 4 mg once followed by 2 mg after each loose stool, not to exceed 16 mg per day, for 3 days. The duration of illness was the number of hours elapsed from the beginning of therapy to the passage of the last unformed stool. Results: Ofloxacin and loperamide were well tolerated. Combination therapy with single dose ofloxacin plus loperamide was significantly more efficacious in reducing the duration of diarrhea than single dose ofloxacin or ofloxacin given for 3 days (p <.00001). Furthermore, combination therapy was more efficacious when enterotoxigenic Escherichia coli (ETEC) was the pathogen (p <.01) or when no pathogen was isolated (p <.001). Sixty-three percent of subjects passed no further unformed stools after the initial doses of combination therapy, and 91% were well by the end of the first 24 hours. Conclusions: The combined use of a single dose of ofloxacin with loperamide is safe and more efficacious in the treatment of traveler's diarrhea than use of ofloxacin alone.
A computer simulation of hearing aid response and the effects of ear canal size (1988)

The response of a hearing aid is affected by many factors which include the head and outer ear, the microphone, amplifier, and receiver used in the hearing aid, the properties of the ear canal and the eardrum, and acoustic feedback through the vent. This article presents a computer simulation of an in-the-ear (ITE) hearing aid that includes all of the above factors. The simulation predicts the pressure at the eardrum for a frontal free-field sound source. The computer model was then used to determine the effects on the hearing aid response due to variations in the size of the ear canal. The simulation indicates that, for an unvented hearing aid, changes in the size of the ear canal shift the overall sound-pressure level at the eardrum but have only small effects on the shape of the frequency response. The situation is more complicated when a vent is present, however, since changes in the size of the ear canal that cause apparently small perturbations in the acoustic feedback signal may, nonetheless, have large effects on the overall system response.
Error-Correcting Isomorphisms of Attributed Relational Graphs for Pattern Analysis (1979)

The pattern deformational model proposed by Tsai and Fu [11] is extended so that numerical attributes and probability or density distributions can be introduced into primitives and relations in a nonhierarchical relational graph. Conventional graph isomorphisms are then generalized to include error-correcting capability for matching deformed patterns represented by such attributed relational graphs. An ordered-search algorithm is proposed for determining error-correcting isomorphisms. Finally, a pattern classification approach using graph isomorphisms is described, which can be considered as a combination of structural and statistical techniques.
Palladium‐Catalyzed Asymmetric Quaternary Stereocenter Formation (2012)

An efficient palladium catalyst is presented for the formation of benzylic quaternary stereocenters by conjugate addition of arylboronic acids to a variety of β,β-disubstituted carbocyclic, heterocyclic, and acyclic enones. The catalyst is readily prepared from PdCl(2), PhBOX, and AgSbF(6), and provides products in up to 99% enantiomeric excess, with good yields. Based on this strategy, (-)-α-cuparenone has been prepared in only two steps.
On the feasibility of a three‐point bending setup for the validation of (fatigue) damage models for thin composite laminates (2008)

Abstract After developing a damage model, validation of this model is a necessity. This validation should preferably be done under loading conditions which are different from the ones used for the development of the model. This study investigates whether a three‐point bending setup is suited for the validation of fatigue material models for thin fiber‐reinforced composites with a low bending stiffness, developed in uniaxial loading conditions. First, the three‐point bending setup, which can be used for both single‐sided and fully reversed loading, is discussed. Then, some results of experiments are presented. This is followed by the numerical modeling of the bending setup. It may be concluded that the three‐point bending setup, although with very interesting loading conditions, is not ideally suited for model validation, due to the complicated and time‐consuming numerical simulation. The material used for this study was a carbon fabric‐reinforced polyphenylene sulphide. POLYM. COMPOS., 2008. © 2008 Society of Plastics Engineers
The venous thrombotic risk of oral contraceptives, effects of oestrogen dose and progestogen type: results of the MEGA case-control study (2009)

Currently available oral contraceptives still have a major impact on thrombosis occurrence and many women do not use the safest brands with regard to risk of venous thrombosis.
Analysis of a source-coupled MOS multivibrator with resistive drain loads (1988)

Abstract The determinant of the system of nodal equations of a source-coupled MOS multivibrator is calculated. Equating this determinant to zero, one can obtain the condition of transition from one quasistable state to another. This condition is used to calculate the currents in the multivibrator transistors at the instant of transition. Then the voltage amplitude at the coupling capacitor is calculated and the oscillation frequency is found. The oscillation frequency in this multivibrator depends on the value of currents supplied to the circuit and the power supply voltage. The results were verified experimentally.
Lysosome docking to WIPI1 rings and ER-connected phagophores occurs during DNAJB12- and GABARAP-dependent selective autophagy of misfolded P23H-rhodopsin (2022)

We report on how the endoplasmic reticulum (ER)-associated-autophagy pathway (ERAA) delivers P23H-rhodopsin (P23H-R) to the lysosome. P23H-R accumulates in an ERAD-resistant conformation that is stabilized in a detergent-soluble state by DNAJB12 and Hsp70. P23H-R, DNAJB12, and FIP200 colocalize in discrete foci that punctuate the rim of omegasome rings coated by WIPI1. Loss of DNAJB12 function prevents the association of P23H-R containing ER tubules with omegasomes. P23H-R tubules thread through the wall of WIPI1 rings into their central cavity. Transfer of P23H-R from ER-connected phagophores to lysosomes requires GABARAP and is associated with the transient docking of lysosomes to WIPI1 rings. After departure from WIPI1 rings, new patches of P23H-R are seen in the membranes of lysosomes. The absence of GABARAP prevents transfer of P23H-R from phagophores to lysosomes without interfering with docking. These data identify lysosome docking to omegasomes as an important step in the DNAJB12- and GABARAP-dependent autophagic disposal of dominantly toxic P23H-R.
Exposure, Lung Function, and Symptoms in Car Painters Exposed to Hexamethylendiisocyanate and Biuret Modified Hexamethylendiisocyanate (1987)

Individuals who paint cars often complain to doctors about respiratory problems. Car painters are exposed to isocyanates, especially hexamethylendiisocyanate (HDI), and biuret modified HDI (HDI-BT). The mean exposure to HDI-BT was 115 micrograms/m3 in the air (range 10-385 micrograms/m3), which exceeds the time-weighted Swedish threshold level of 90 micrograms/m3. Exposure to HDI was about 1.0 microgram/m3 with brief peaks. This study investigated the effect of HDI and HDI-BT on lung function and included two control groups: (1) car platers, exposed to the same solvents and grinding dust as car painters, but not to isocyanates, and (2) car mechanics (controls), not exposed to the mentioned agents. Car painters and car platers were compared to car mechanics on Monday before work. Acute effects of car painting were tested by comparing the lung function values on Monday morning with those on Friday afternoon. Pulmonary function was evaluated by means of spirometry and a single breath nitrogen washout. Spirometry in painters and platers did not differ from that in controls, i.e., car mechanics. Closing volume in relation to vital capacity (CV%) was increased in car painters, suggestive of a "small airways disease" on Monday before work and tended to increase during a work week. Car platers did not differ from controls.
THE EFFECT OF RADIATIONS FROM A MERCURY ARC IN QUARTZ ON ENZYMES (1931)

Amylase in solution is inactivated by the radiations from a mercury arc in quartz, in a manner similar to that previously reported for pepsin. The reaction was followed to a point where more than 88 per cent change had taken place, the course being that of mono-molecular radiochemical change. Apparently, this reaction is due to the influence of ultra-violet radiation alone.
Modelling and robust control of fluidic thrust vectoring and circulation control for unmanned air vehicles (2008)

This paper presents actuator models for fluidic thrust vectoring and circulation control and they are used in the design of a robust controller for an unmanned air vehicle. The pitching and rolling moments for the aircraft are produced through the use of a co-flow fluidic thrust vectoring arrangement at the wing trailing edges. Experimental results for the co-flow actuators are used to derive mathematical models and their performance is compared with conventional control surfaces. For the controller design, nonlinear dynamic models are approximated by a simplified linear parameter varying (LPV) model. The polytopic nature of the controller is exploited to reformulate the LPV controller design problem into a m-synthesis problem. The LPV controllers exhibit superior stability properties over the entire operating region, when compared to conventional gain-scheduling schemes.
A Fine-Grained Data Reconstruction Algorithm for Solid-State Disks (2010)

Solid-state disks (SSDs) with high I/O performance are increasingly becoming popular. To extend the life time of flash memory, one can apply wear-leveling strategies to manage data blocks. However, wear-leveling strategies certainly inevitably degrade write performance. In addition to low write performance, wear-leveling strategies make one block unwritable when one bit of this block is invalid. Although data reconstruction techniques have been widely employed in disk arrays, the reconstruction techniques has not been studied in the context of solid-state disks. In this paper, we present a new fine-grained data-reconstruction algorithm for solid-state disks. The algorithm aims to provide a simple yet efficient wear-leveling strategy that improves both I/O performance and reliability of solid-state disks. Simulation experiments show that all data blocks have very similar in terms of erasure times. The number of extra erasures incurred by our algorithm is very marginal.
X-Ray Lithography Applied To The Fabrication Of One Micrometer N-Channel Metal Oxide Semiconductor Circuits (1983)

A full-field x-ray exposure system based on a 4 kW stationary palladium source emitting the 4.37 A La line has been developed and evaluated in the fabrication of silicon integrated circuits. It has been used successfully in the patterning of 1 um design rule high performance n-channel metal oxide semi-conductor (NMOS) circuits of various complexities from ring oscillators to large scale custom logic and memory devices. A shadow mask consisting of a 6µm boron nitride membrane and 0.7 pm gold-tantalum features is used to transfer patterns into a chlorine-based x-ray resist sensitive to the 4.37 A radiation. Pattern transfer to the silicon surface is faithfully reproduced through the use of a trilevel structure and anisotropic reactive ion etching. Alignment of various levels is accomplished optically through the use of a bifocal, split-field microscope at high magnification and the use of dark-field edge sensing for improved contrast. Linewidth control and registration data are presented for various NMOS circuit patterns.
Microbial degradation of DDT and its residues—A review (1997)

Abstract Microbial degradation of DDT residues is one mechanism for loss of DDT from soil. In this review pathways for biodegradation of DDT, DDD, and DDE by bacteria and fungi are described. Biodegradation of DDT residues can proceed in soil, albeit at a slow rate. To enhance degradation in situ a number of strategies are proposed. They include the addition of DDT‐metabolising microbes to contaminated soils and/or the manipulation of environmental conditions to enhance the activity of these microbes. Ligninolytic fungi and chlorobiphenyl degrading bacteria are promising candidates for remediation. Flooding of soil and the addition of organic matter can enhance DDT degradation. As biodegradation may be inhibited by lack of access of the microbe to the contaminant, the soil may need to be pre‐treated with a surfactant. Unlike DDT, little is known about the biodegradation of DDE, and this knowledge is crucial as DDE can be the predominant residue in some soils.
FPGA prototyping of an ASIP LDPC decoder for the DVB-T2 standard (2012)

Forward Error Correction (FEC) consists in the addition of redundancy to the binary information sequence before the transmission. This redundancy allows the FEC decoder to detect and/or to correct the effects of noise and interference encountered during the transmission. An ASIP LDPC decoder compliant with DVB-T2 standard is presented in this paper.
Ixekizumab, an interleukin-17A specific monoclonal antibody, for the treatment of biologic-naive patients with active psoriatic arthritis: results from the 24-week randomised, double-blind, placebo-controlled and active (adalimumab)-controlled period of the phase III trial SPIRIT-P1 (2016)

NCT01695239; EudraCT2011-002326-49; Results.