gebhart/patrepeval huggingface dataset:
Porous Scaffolds Support Extrahepatic Human Islet Transplantation, Engraftment, and Function in Mice (2012)

Islet transplantation as a therapy or cure for type 1 diabetes has significant promise but has been limited by islet mass requirements and long-term graft failure. The intrahepatic and intravascular site may be responsible for significant loss of transplanted islets. Nonencapsulating biomaterial scaffolds provide a strategy for architecturally defining and modulating extrahepatic sites beyond the endogenous milieu to enhance islet survival and function. We utilized scaffolds to transplant human islets into the intraperitoneal fat of immunodeficient mice. A smaller human islet mass than previously reported reversed murine diabetes and restored glycemic control at human blood glucose levels. Graft function was highly dependent on the islet number transplanted and directly correlated to islet viability, as determined by the ATP-to-DNA ratio. Islets engrafted and revascularized in host tissue, and glucose tolerance testing indicated performance equivalent to healthy mice. Addition of extracellular matrix, specifically collagen IV, to scaffold surfaces improved graft function compared to serum-supplemented media. Porous scaffolds can facilitate efficient human islet transplantation and provide a platform for modulating the islet microenvironment, in ways not possible with current clinical strategies, to enhance islet engraftment and function.
As(III) oxidation using chemical and solid‐phase oxidants (2004)

The effectiveness of seven oxidants—chlorine (Cl 2 ), permanganate (MnO 4 − ), ozone (O 3 ), monochloramine (NH 2 Cl), chlorine dioxide (ClO 2 ), a manganese dioxide‐based solid‐oxidizing media, and 254‐nm ultraviolet radiation—for arsenite [As(III)] oxidation to arsenate was studied. The effect of water chemistry variables including pH, temperature, and interfering reductants (manganous and ferrous ions, sulfide, and total organic carbon [TOC]) was investigated. Cl 2 and MnO 4 − provided complete oxidation in less than 1 min under all conditions tested. The effectiveness of O 3 was significantly attenuated in the presence of TOC. Both ClO 2 (an otherwise powerful oxidant) and NH 2 Cl were ineffective for As(III) oxidation. When dissolved oxygen (DO) was not limiting, the solid‐oxidizing media provided complete oxidation. However, with low DO and interfering reductants, incomplete oxidation was observed. The adverse effect of interfering reductants was eliminated either by supplying enough DO or reducing the flow rate. UV light alone (254 nm) was not effective, but complete As(III) oxidation was observed when the feedwater was spiked with 1 mg/L of sulfite.
QoE-driven live and on-demand LTE uplink video transmission (2011)

We consider the joint upstreaming of live and on-demand user-generated video content over LTE using a Quality-of-Experience driven approach. We contribute to the state-of-the-art work on multimedia scheduling in three aspects: 1) we jointly optimize the transmission of live and time-shifted video under scarce uplink resources by transmitting a basic quality in realtime and uploading a refined quality for on-demand consumption. 2) We propose a producer-consumer deadline-aware scheduling algorithm that incorporates both the physical state of the mobile producer (e.g., cache fullness) and the scheduled playout time at the end-user. 3) We show that the scheduling decisions in 1) and 2) can be determined locally for each mobile producer. We additionally present an analytical framework for de-centralized scalable video transmission and prove that there exists an optimal solution to our problem. Simulation results for LTE uplink further demonstrate the significance of our proposed optimization on the overall user experience.
Electrochemical and Spectroscopic Properties of Cation Radicals: III . Reaction Pathways of Carbazolium Radical Ions (1975)

Previous work had elucidated the anodic oxidation pathways of carbazole and several N‐substituted derivatives. These studies have now been extended to seventy‐six ring‐substituted carbazoles using electrochemical and spectroscopic techniques to study the reactivity of the various substituted carbazole cation radicals. Generally, it was found that 3, 6, and 9 (N) positions are extremely reactive; if these sites are not blocked by inert substituents the cation radicals generated by electrolytic oxidation react rapidly via coupling‐deprotonation. In some cases, substituents are eliminated from the 3 and 6 positions in the cation radicals followed by coupling to form substituted bicarbazyls. In other cases, relatively stable cation radicals were obtained and their EPR and visible absorption spectra were recorded. It was found that the reactivities of substituted carbazole cation radicals are considerably greater than those of analogous di‐ and triphenylaminium ions due to the planarity of the carbazole aromatic rings.
Silver nanowires with semiconducting ligands for low-temperature transparent conductors (2016)

Metal nanowire networks represent a promising candidate for the rapid fabrication of transparent electrodes with high transmission and low sheet-resistance values at very low deposition temperatures. A commonly encountered challenge in the formation of conductive nanowire electrodes is establishing high-quality electronic contact between nanowires to facilitate long-range current transport through the network. A new system involving nanowire ligand removal and replacement with a semiconducting sol-gel tin oxide matrix has enabled the fabrication of high-performance transparent electrodes at dramatically reduced temperatures with minimal need for post-deposition treatment.
Preparation of Highly Pure Fine Mullite Powder (1989)

The preparation of high‐purity mullite powders (3Al 2 O 3 · 2SiO 2 ) was examined using aluminum salts or boehmite and fumed silica. The combination of aluminum sulfate and fumed silica was found to have the highest quality for mullite powder. A slurry consisting of an aqueous solution of aluminum sulfate and fumed silica was dried and heated at 1350°C and was attrition‐milled for 2 h. The mullite powder obtained was composed of submicrometer, uniform, and equiaxial particles with narrow size distribution. It was hot‐pressed at 1600°C for 1 h under 10 MPa or was sintered at 1650°C for 3 h. The bulk densities of the products made by both processes were 3.16 and 3.09 g/cm 3 .
28 Potential Role of Scavenger Receptors in Human Mast Cell Cytokine Response to Oxidized ldl (2012)

BACKGROUND: Human atherosclerotic lesions contain mast cells and oxidatively modified low-density lipoprotein particles (oxLDL). Scavenger receptors are cell surface receptors that bind and internalize oxLDL, and they play an important role in macrophage foam cell development, a key event in the initiation and development of atherosclerotic lesions. The purpose of the study was to analyze expression of the most common scavenger receptors in mast cells, and determine whether oxLDL particles can induce them to secrete pro-inflammatory cytokines that are potentially capable of inducing and amplifying atherogenic processes. METHODS: Mast cells were differentiated from human cord blood-derived CD34+ progenitor cells in vitro (CBMC), and their expression of scavenger receptors was analyzed by conventional RT-PCR, flow cytometry and Western blot techniques. Fluorescently-labeled oxLDL was used to investigate LDL internalization by mast cells. Secretion of pro-inflammatory cytokines into the incubation medium and degranulation of the mast cells in response to oxLDL were assayed by ELISA and a colorimetric-enzymatic test for beta-hexosaminidase, respectively. RESULTS: CBMC expressed mRNA and protein for LOX-1, SR-AI and CD68, but not for CD36, and the expression of LOX-1 and SR-AI was upregulated by incubation of the cells with oxLDL. CBMC internalized oxLDL more efficiently than native LDL, while simultaneous neutralization of CD68, SR-AI and LOX-1 with monoclonal antibodies resulted in reduced oxLDL uptake. Moreover, in response to oxLDL, CBMC showed increased release of β-hexosaminidase, and a dose-dependent secretion of the pro-inflammatory cytokines IL-8 and MCP-1. CONCLUSION: Our results reveal that cultured human mast cells express scavenger receptors that are upregulated by oxLDL. In atherosclerotic lesions, oxLDL may activate MC to secrete pro-inflammatory cytokines, and so they cause mast cells to act as a cellular link between oxLDL and the inflammatory response in atherosclerosis.
Interrelationships between Cellular Nucleotide Excision Repair, Cisplatin Cytotoxicity, HER‐2/neu Gene Expression, and Epidermal Growth Factor Receptor Level in Non‐small Cell Lung Cancer Cells (2000)

Nucleotide excision repair (NER) is a major repair mechanism for DNA lesions induced by cisplatin. Overexpressions of epidermal growth factor receptor (EGFR) and HER-2/neu have been reported to affect the sensitivity of certain human cancer cells to cisplatin, presumably by modification of DNA repair activity through interference with NER. Using an in vitro repair assay, we investigated NER activity of cisplatin-induced DNA lesions in a panel of 16 non-small cell lung cancer (NSCLC) cell lines. The interrelationships between NER activity, cisplatin sensitivity, HER-2/neu expression and EGFR level, were also analyzed. The results showed that high NER activity was closely correlated with cisplatin resistance and high levels of HER-2/neu expression (P<0.05). Analysis of the relationships between EGFR level and each of the other three parameters revealed no statistically significant correlations (all P values were >0.05 by Spearman rank correlation), but a trend of association (all the values of proportion of accordance were > or =62.5% by using a 2x2 contingency table). These results suggest that NER activity may play an important role in the cisplatin resistance of NSCLC cells and there may be an association between enhanced NER activity and high levels of p185neu and probably EGFR in NSCLC cells. The finding that high levels of EGFR showed very little influence on the relationship between p185neu and cisplatin resistance suggests that EGFR may be a less crucial factor in modulating the chemoresistance of NSCLC cells when compared with HER-2/neu.
Identification of three new alternatively spliced variants of the rat mu opioid receptor gene: dissociation of affinity and efficacy (2004)

Mu opioid receptors mediate the pharmacological actions of morphine and morphine-like drugs, such as heroin. The mouse and human Oprm genes undergo splicing. In these present studies, we have identified and characterized three new MOR-1 splice variants from the rat Oprm gene. Using an RT-PCR approach, we isolated the new exons 7, 8 and 9 downstream of exon 3. The rat exons 7 and 9 were homologous to the mouse exons 7 and 9 while the rat exon 8 was not. Northern blot analysis with the new exon probes showed distinctive and abundant transcripts of the variants in the rat brain. Full-length cDNA clones containing the new exons, rMOR-1C1, rMOR-1C2 and rMOR-1D were obtained using an RT-PCR approach. Each contained the same exons 1, 2 and 3 as the original rMOR-1, followed by different combinations of the new exons in place of exon 4. In addition, we also isolated another new variant, rMOR-1A, which contains only exons 1, 2 and 3, and is homologous to the human variant MOR-1A previously identified. All the variants were highly mu-selective in binding studies with little difference in affinities for the mu ligands among the variants. However, functional evaluation of assessments of the variants using agonist stimulated [(35)S]GTPgammaS binding assays revealed marked differences among the variants, both in terms of potency and efficacy of the drugs. The relative efficacy of a series of mu opioids to each other varied depending upon the variant studied. Efficacy in the [(35)S]GTPgammaS assay did not correlate with either receptor binding affinity or with potency. Thus, selectivity of opioid action might be achieved by designing compounds with varying efficacies at different MOR-1 variants.
Effects Of Endotoxin In The Lungs Of Neonatal Rats: Age-Dependent Impairment Of The Inflammatory Response (1995)

Age-dependent maturation of the intrapulmonary inflammatory responses to bacterial lipopolysaccharide (LPS) was studied because nosocomial gram-negative infections cause morbidity in newborn infants. Escherichia coli LPS or live E. coli were injected into the airways of neonatal or adult rats; intrapulmonary recruitment of leukocytes was measured 6 h later. Neonates showed age- and dose-dependent impairment of intrapulmonary neutrophil recruitment after intratracheal administration of LPS or live E. coli that persisted for the first 28 days of life. Neonatal and adult alveolar macrophages released similar amounts of neutrophil chemotactic activity and tumor necrosis factor in response to incubation with LPS in vitro. Treatment of neonates with intratracheal or systemic interferon-gamma did not augment the response to LPS. Thus, intrapulmonary inflammatory responses to LPS and gram-negative bacteria are impaired early in life and do not approach adult levels until approximately 4 weeks of age.
Adaptive H/sub /spl infin//-control for nonlinear systems (1997)

The adaptive H/sub /spl infin//-control problem for parameter-dependent nonlinear systems with full information feedback is addressed. The dissipation theoretic techniques as well as projection methods are used to derive the adaptive H/sub /spl infin//-control laws.
The Chemistry of Dienes and Polyenes (1997)

Partial table of contents: Contribution of Quantum Chemistry to the Study of Dienes and Polyenes (V. Branchadell, et al.). Thermochemistry of Dienes and Polyenes (J. Liebman) Radiation Chemistry of Dienes and Polyenes (Z. Alfassi). Analysis of Dienes and Polyenes and their Structure Determination (Z. Aizenshtat). Radical Addition to Polyenes (H. Zipse). Structural Effects on Dienes and Polyenes (M. Charton). Allenyl and Polyenyl Cations (L. Subramanian). Synthesis and Transformation of Radialenes (G. Maas & H. Hopf). Indexes.
The PredictProtein server (2003)

PredictProtein (PP, http://cubic.bioc.columbia.edu/pp/) is an internet service for sequence analysis and the prediction of aspects of protein structure and function. Users submit protein sequence or alignments; the server returns a multiple sequence alignment, PROSITE sequence motifs, low-complexity regions (SEG), ProDom domain assignments, nuclear localisation signals, regions lacking regular structure and predictions of secondary structure, solvent accessibility, globular regions, transmembrane helices, coiled-coil regions, structural switch regions and disulfide-bonds. Upon request, fold recognition by prediction-based threading is available. For all services, users can submit their query either by electronic mail or interactively from World Wide Web.
Transaction synchronization protocol using XML in client-server environment (2009)

The problem of transaction synchronization is important in XML-based applications based on client-server model, especially when both server and clients are allowed to store data. When clients modify their local database, writing this transaction back to the server and to all other clients requires transaction synchronization. To achieve reliable and efficient transaction synchronization, there is a need for some sort of efficient protocol that can guarantee the synchronization of databases on the server and all clients. In this paper, a protocol is proposed for transaction synchronization using XML database and XML as a transfer medium between the server and clients. Importantly, this protocol can be used in any type of database with XML as a data transfer medium using some kind of database mapping from any database to XML. This protocol significantly reduces the cost of data transfer between server and clients, thus increasing efficiency.
Venereal Transmission of La Crosse Virus from Male to Female Aedes Triseriatus (1978)

Horizontal transmission of La Crosse (LAC) arbovirus in colonized Aedes triseriatus was first observed in mating cages. LAC antigen was visualized by fluorescent antibody technique in multiple organs of 5 (2.5% of 198 females dissected after contact in mating cages with males, with a transovarial infection rate of 31%. Venereal transmission of LAC virus was demonstrated by limited contact induced mating. Antigen was detected in bursal contents of 35 (53%) of 66 females dissected within 24 h after induced mating by males previously infected by intrathoracic inoculation. Antigen was observed in ovaries, heart, gut, salivary glands, or other organs in 13 (3.4%) of 379 females dissected 1 to 14 days post-mating. LAC virus was isolated from infected males, from contents of the bursa copulatrix of females following mating, and from dissection remnants of 6 of the 13 females in which disseminated antigen had been observed. Venereally infected females were shown to be capable of transmission of LAC virus by bite to mice and to eggs.
The effect of prostaglandin modulators on prostate tumor growth and metastasis. (1985)

The purpose of this study was to investigate the effect of prostaglandin modulating drugs on the growth and metastasis of experimental prostate tumor. Nb rats bearing subcutaneous implants of an androgen-insensitive prostate adenocarcinoma were treated with indomethacin, a cyclooxygenase inhibitor, UK 38485, a thromboxane synthetase inhibitor, and nafazatrom, an antithrombotic agent which is thought to act by enhancing endogenous prostacyclin synthesis. Animals treated with these three drugs had significantly lower pulmonary metastasis than the untreated controls. The effect on primary tumor volume and mortality was variable. We conclude that shifting prostaglandin hemostasis in the tumor bearing animals in favor of prostacyclin, reduces pulmonary metastasis in this experimental tumor system.
Modeling and Design of an Electro-Rheological Fluid Based Haptic System for Tele-Operation of Space Robots (2000)

International audience
Traitement d'antenne, localisation de sources en acoustique sous-marine. (2007)

International audience
Polymorphisms of Serotonin Receptor 2A and 2C Genes and COMT in Relation to Obesity and Type 2 Diabetes (2009)

The findings lend further support to the involvement of serotonin, noradrenaline and dopamine pathways on obesity and glucose homeostasis, in particular when combined genotype associations are explored.
Nanoparticle‐Programmed Self‐Destructive Neural Stem Cells for Glioblastoma Targeting and Therapy (2013)

A 3-step glioblastoma-tropic delivery and therapy method using nanoparticle programmed self-destructive neural stem cells (NSCs) is demonstrated in vivo: 1) FDA-approved NSCs for clinical trials are loaded with pH-sensitive MSN-Dox; 2) the nanoparticle conjugates provide a delayed drug-releasing mechanism and allow for NSC migration towards a distant tumor site; 3) NSCs eventually undergo cell death and release impregnated MSN-Dox, which subsequently induces toxicity towards surrounding glioma cells.
Basic and clinical applications of flow cytometry : proceedings of the 24th Annual Detroit Cancer Symposium, Detroit, Michigan, USA, April 30, May 1 and 2, 1992 (1996)

1. Cytometry 2000: laser probing the future A. Nakeff. 2. Activation and proliferation of purified hematopoietic precursor cells from human bone marrow P. Lansdorp, et al. 3. Flow cytometric proliferative fraction analysis in solid tumors D. Visscher, et al. 4. Mitogenic and non-mitogenic induction of lymphocytic invasion: dual parameter flow cytometric analysis S. Ratner, D. Lichlyter. 5. Flow cytometric monitoring of drug resistance in human solid tumors A. Krishan, et al. 6. Flow cytometry in oncology: some lessons from history H.M. Shapiro. DNA flow cytometry application to clinical trials in breast cancer L.G. Dressler. 8. Processing of solid tumors for DNA analysis by flow cytometry C.L. Hitchcock, et al. 9. SJL model for lymphoma treatment M. Cankovic, et al. 10. Gene mapping and molecular cytogenetics using flow-sorted chromosomes N.P. Carter. 11. The clinical potential of DNA content parameters in human pediatric and adult solid tumors M. Zalupski, J.F. Ensley. 12. Differentiation of human B-cell tumors: a preclinical model for differentiation therapy A.M. Al-Katib, R. Mohammad. Probing immune responses: the role of intracellular glutathione M. Roederer, L.A. Herzenberg. DNA topoisomerase II poisons and the cell cycle P.J. Smith. 15. In situ hybridization of centromeric DNA as visualized on the nuclear matrix by laser confocal cytometry K.J. Pienta. 16. Megakaryocytopoiesis 2000 A. Nakeff. 17. The molecular basis for the control of mammalian cell growth G.I. Evan. 18. Isolation of rare cells by high-speed flow cytometry and high-resolution cell sorting for subsequent molecular characterization -- application in prenatal diagnosis, breast cancer and autologous bone marrow transplantation J.F. Leary, et al.
Waterflooding under fracturing conditions (1988)

Changes in reservoir pressure or temperature can change the stress field in the reservoir rock.Such changes in the stress field influence the conditions under which fracturing of the reservoir rock can occur.They also influence the geometry and direction of propagation of induced fractures.This chapter presents new analytical and numerical methods for calculating the stress field around a single vertical well in an infinite reservoir.Poro-and thermo-elastic variations in the stress field resulting from axisymmetric changes in reservoir pressure and temperature are incorporated.The methods are general in the sense that no use is made of the assumption of plane strain.The formulae presented allow application of arbitrary axisymmetric pressure and temperature fields.Simple analytical formulae for thermo-elastic stress variations are presented for temperature distributions with a step profile.Simple analytical formulae for poro-elastic stress variations are presented for quasi, steady-state pressure profiles including discontinuities in fluid mobility.Analytical expressions for the fracture initiation pressure including poro-and thermo-elastic effects are presented.The numerical and analytical methods are used to evaluate the change in fracturing conditions for two realistic field cases.The first is a high-permeability reservoir in which a large thermo-elastic reduction in rock stress occurs following the injection of cold water.Thermal fractures may be induced under such conditions.These fractures are likely to remain contained within the cooled reservoir region.The second case is a low-permeability reservoir for which the poro-elastic increase in rock stress due to the rise in pore-pressure is dominant with respect to the cooling effect.The fracture initiation pressure of the reservoir has therefore increased.The stresses in cap and base rock have decreased because of cooling.The induced stress gradients may force created fractures to grow vertically into cap and base rock.
THz time-domain spectroscopy of multilayer filters (2011)

We present simulations, fabrication and characterization of multilayer filters for THz frequency applications. Cascaded layers of symmetrical and asymmetrical frequency selective filters were investigated. The proposed filters exhibited superior transmission characteristics when compared to conventional devices based on single layers.
230-mW diode-pumped single-frequency Er:Yb laser at 1.5 μm (2001)

We report on a diode-pumped Er:Yb laser able to generate a single-frequency output power in excess of 200 mW at both 1.53 μm and 1.56 μm and over 300 mW in multimode operation. The tuning characteristics of the source are reported and discussed. The relative intensity noise presents in all configurations a peak value lower than -92 dB/Hz and its level decreases below -160 dB/Hz for frequencies higher than 8 MHz.