gebhart/patrepeval huggingface dataset:
[Psychotherapy of post-traumatic borderline neuropsychiatric disorders]. (1989)

A study of borderline neuro-psychic disorders observed in he restorative period of head injuries revealed their polymorphous character and the necessity of psychotherapy. The author carried out a psychotherapeutic program (rational psychotherapy, prolonged sleep-hypnosis, hypnosuggestion, psychotherapeutic passes) that essentially increased the efficiency of treatment of borderline neuro-psychic disorders in the restorative period of head injuries.
On practical specification and enforcement of obligations (2012)

Obligations are an important and indispensable part of many access control policies, such as those in DRM (Digital Rights Management) and healthcare information systems. To be able use obligations in a real-world access control system, there must exist a language for specifying obligations. However, such a language is currently lacking. XACML (eXtensible Access Control Markup Language), the current de facto standard for specifying access control policies, seems to integrate obligations as a part of it, but it treats obligations largely as black boxes, without specifying what an obligation should include and how to handle them. In this paper we examine the challenges in designing a practical approach for specifying and handling obligations, and then propose a language for specifying obligations, and an architecture for handling access control policies with these obligations, extending XACML's specification and architecture. In our design, obligations are modeled as state machines which communicate with the access control system and the outside world via events. We further implement our design into a prototype system named ExtXACML, based on SUN's XACML implementation. ExtXACML is extensible in that new obligation modules can be added into the system to handle various obligations for different applications, which shows the strong power of our design.
Performance of Maximal Ratio and Optimum Combining with Channel Estimation Errors and Multiple Interferers in Rayleigh Fading Channels (2006)

This paper analyzes the performance of maximal ratio combining (MRC) and compares it with the performance of optimum combining (OC) in the presence of channel estimation errors and multiple interferers in a flat Rayleigh fading environment. The probability density function (PDF) of the signal-to-interference-plus-noise ratio at the output of the maximal ratio combiner has been derived in prior work, assuming Gaussian channel estimation errors. We use that PDF to derive analytical expressions for a number of important performance measures such as the outage probability and the average bit error probability for different modulation formats in interference-limited systems. These expressions are used to show that the simpler MRC method can outperform the more complex OC receiver when the channel estimator performs poorly, and quantify the threshold of correlation between the true and estimated channels at which the cross-over occurs.
Adaptive modulation using long range prediction for flat Rayleigh fading channels (2002)

We theoretically analyze the statistical behavior of prediction errors generated by our previously proposed (Duel-Hallen et al. 2000) long range prediction algorithm, and investigate adaptive modulation design using predicted channel state information (CSI). Both numerical and simulation results show that accurate prediction of the fading channel far ahead makes adaptive transmission feasible for rapidly time-varying mobile radio channels.
A Wireless Passive Pressure Microsensor Fabricated in HTCC MEMS Technology for Harsh Environments (2013)

A wireless passive high-temperature pressure sensor without evacuation channel fabricated in high-temperature co-fired ceramics (HTCC) technology is proposed. The properties of the HTCC material ensure the sensor can be applied in harsh environments. The sensor without evacuation channel can be completely gastight. The wireless data is obtained with a reader antenna by mutual inductance coupling. Experimental systems are designed to obtain the frequency-pressure characteristic, frequency-temperature characteristic and coupling distance. Experimental results show that the sensor can be coupled with an antenna at 600 °C and max distance of 2.8 cm at room temperature. The senor sensitivity is about 860 Hz/bar and hysteresis error and repeatability error are quite low.
Infrared Emission-based Static Logic State Imaging on Advanced Silicon Technologies (2002)

Abstract A technique is presented for mapping the logic states of CMOS integrated circuits by observing their static infrared emission. Application of the technique is shown in two case studies. The technique has the advantages of being non-invasive, having high observability and reduced complexity compared with dynamic probing techniques.
Bone morphogenetic protein‐9 induces epithelial to mesenchymal transition in hepatocellular carcinoma cells (2013)

Epithelial-mesenchymal transition (EMT) is an important mechanism to initiate cancer invasion and metastasis. Bone morphogenetic protein (BMP)-9 is a member of the transforming growth factor (TGF)-β superfamily. It has been suggested to play a role in cancer development in some non-hepatic tumors. In the present study, two hepatocellular carcinoma (HCC) lines, HLE and HepG2, were treated with BMP-9 in vitro, and phenotypic changes and cell motility were analyzed. In situ hybridization (ISH) and immunohistochemical analyses were performed with human HCC tissue samples in order to assess expression levels of BMP-9. In vivo, BMP-9 protein and mRNA were expressed in all the tested patients to diverse degrees. At the protein level, mildly positive (1 + ) BMP-9 staining could be observed in 25/41 (61%), and moderately to strongly positive (2 + ) in 16/41 (39%) of the patients. In 27/41 (65%) patients, the BMP-9 protein expression level was consistent with the mRNA expression level as measured by ISH. In those patients with 2 + protein level, nuclear pSmad1 expression in cancer cells was also significantly increased. Expression of BMP-9 was positively related to nuclear Snail expression and reversely correlated to cell surface E-cadherin expression, although this did not reach statistical significance. Expression levels of BMP-9 were significantly associated with the T stages of the investigated tumors and high levels of BMP-9 were detected by immunofluorescence especially at the tumor borders in samples from an HCC mouse model. In vitro, BMP-9 treatment caused a reduction of E-cadherin and ZO-1 and an induction of Vimentin and Snail expression. Furthermore, cell migration was enhanced by BMP-9 in both HCC cell lines. These results imply that EMT induced by BMP-9 is related to invasiveness of HCC.
Affinity-purified interleukin 2 induces proliferation of large but not small B cells. (1985)

Immunoaffinity-purified interleukin 2 (IL2) stimulated proliferation of large but not small B cells. Stimulation was observed even when B cells were cultured at very low cell densities (3 X 10(4) per microwell containing 0.2 ml of medium). Addition of small numbers of purified splenic T cells did not enhance the IL2-induced B-cell proliferative response. These results suggest that IL2 was not operating through contaminating T cells. B cells cultured with anti-Ig antibody in vitro showed enhanced proliferation when cultured with EL4 thymoma-derived B-cell growth factor but not when cultured with IL2. A direct role for IL2 in B-cell activation is discussed.
Type 1 interleukin‐1 receptor in the rat brain: Distribution, regulation, and relationship to sites of IL‐1–induced cellular activation (1995)

Systemic interleukin-1 (IL-1) activates the hypothalamo-pituitary-adrenal (HPA) axis, an effect exerted through increased synthesis and secretion of corticotropin-releasing factor (CRF) by parvicellular neurosecretory neurons. The site(s) and mechanism(s) through which circulating IL-1 may access central systems governing HPA axis output remain obscure. To identify potential cellular targets for blood-borne IL-1, we analyzed the distribution of mRNA encoding the rat type 1 IL-1 receptor (IL-1R1) in rat brain. Regional ribonuclease protection assays detected a single protected fragment corresponding to the membrane-bound form of the IL-1R1 mRNA in all areas analyzed. In situ hybridization revealed labeling predominantly over barrier-related cells, including the leptomeninges, non-tanycytic portions of the ependyma, the choroid plexus, and vascular endothelium. Low to moderate levels of the IL-1R1 mRNA were detected in just a few neuronal cell groups, including the basolateral nucleus of the amygdala, the arcuate nucleus of the hypothalamus, the trigeminal and hypoglossal motor nuclei, and the area postrema. No specific labeling for IL-1R1 mRNA was detected over neurons that respond to intravenous IL-1 beta by induction of transcription factor Fos, including hypophysiotropic CRF cells and brainstem catecholamine neurons. Injection of IL-1 beta did, however, provoke induction of mRNA encoding the immediate-early gene, NGFI-B, but not c-fos, in two major loci of IL-1R1 expression, vascular endothelial cells, and the area postrema. Intravenous injection of IL-1 beta acutely down-regulated IL-1R1 mRNA in perivascular cells, but not in neuronal cell groups. These results suggest the parenchymal sites of IL-1R1 expression in rat to be distinct from those reported previously in mouse. The common expression in both species of an IL-1R in non-neuronal elements highlights the possibility that IL-1-mediated activation of CRF neurons may result from cytokine-receptor interaction at vascular, and/or other barrier-related, sites to trigger release of secondary signalling molecules in a position to interact with components of HPA control circuitry.
ChemInform Abstract: Recent Developments in Solid‐Phase Microextraction (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Lysosomal free sialic acid storage disorders with different phenotypic presentations--infantile-form sialic acid storage disease and Salla disease--represent allelic disorders on 6q14-15. (1995)

Similarities in biochemical findings have suggested that Salla disease (SD) and the infantile form of sialic acid storage disease (ISSD) could represent allelic disorders, despite their drastically different clinical phenotypes. SD and ISSD are both characterized by lysosomal storage of free N-acetyl neuraminic acid. However, in SD the increase detected in urine is 8-24-fold, whereas in ISSD the corresponding amount is 20-50-fold and patients are also more severely affected. Here we report linkage studies in 50 Finnish SD families and 26 non-Finnish families with no genealogical connections to Finns affected either with the Finnish type of SD, the "intermediate" form of the disease, or ISSD. All forms of the disease show linkage to the same locus on 6q14-q15. Haplotype analyses of Finnish SD chromosomes revealed one common haplotype, which was also seen in most of the non-Finnish patients with Finnish type of SD. This ancestral haplotype deviated from those observed in ISSD patients, who had a different common haplotype.
Calcium alginate bead manufacture: With and without immobilised yeast. Drop formation at a two‐fluid nozzle (1995)

Abstract Two models were developed to predict the size of drops of aqueous sodium alginate solution formed at a two‐fluid nozzle. Experimental results revealed that actual drop sizes lay between the sizes predicted by the two models. Drop size was closely predicted by the volume mean of the two models. Several nozzles were tested and the influence of operating conditions on drop diameter was examined, with gas velocity and nozzle outer diameter having the largest effect. Only two nozzles would be needed to produce drops with diameters in the range 1–6 mm. The addition of yeast in amounts of up to 10% (w/w) had no effect on operation of the nozzles.
Orientation and Workspace Analysis of the Multifingered Metamorphic Hand—Metahand (2009)

This paper introduces for the first time a metamorphic palm and presents a novel multifingered hand, known as Matahand, with a foldable and flexible palm that makes the hand adaptable and reconfigurable. The orientation and pose of the new robotic hand are enhanced by additional motion of the palm, and workspace of the robotic fingers is complemented with the palm motion. To analyze this enhanced workspace, this paper introduces finger-orientation planes to relate the finger orientation to palm various configurations. Normals of these orientation planes are used to construct a Gauss map. Adding an additional dimension, a 4-D ruled surface is generated to illustrate orientation and pose change of the hand, and an orientation-pose manifold is developed from the orientation-pose ruled surface. The orientation and workspace analysis are further developed by introducing a triangular palm workspace that evolves into a helical surface and is further developed into a 4-D representation. Simulations are presented to illustrate the characteristics of this new dexterous hand.
Vision-based intelligent forklift Automatic Guided Vehicle (AGV) (2015)

This paper develops a new vision-based intelligent forklift Automatic Guided Vehicle (A GV) to perform various transporting tasks in factories and warehouses for improving the quality and efficiency as well as saving the manpower in manufacturing and service industries. Based on a vision-based adaptive localization algorithm with the global pose correction and a visual servo motion controller, the automatic driving function of the A GV can be realized. Experiments conducted in a factory validate performance of the vision-based intelligent forklift A GV.
Urethral Stricture Following Cardiovascular Surgery: Role of Urethral Ischemia (1986)

The incidence of urethral stricture has been surprisingly high following cardiovascular surgery in the last few years. We conducted a prospective study on 68 male patients undergoing cardiovascular surgery to determine the main factor(s) responsible for the development of urethral stricture. The penile-brachial pressure index was checked by strain gauge plethysmography. We found that urethral strictures developed in 15 patients (22 per cent) within an average of 3 months after cardiovascular surgery. Of these patients 13 had a penile-brachial index of 0.6 or less and complained of erectile impotence. A latex type of catheter was used in 11 and a silicone catheter in 4 of these 15 patients for urinary drainage. We conclude that urethral ischemia has an important role in the development of stricture, particularly when a latex urethral catheter is used for drainage. We recommend that a vascular penile study should be done in patients with erectile impotence undergoing an open heart operation, and that serious consideration should be given to the use of a cystocatheter diversion the night before the operation in those with a penile-brachial index less than 0.6. We strongly recommend the use of a silicone catheter in all other patients undergoing open heart surgery with hypothermia.
Promoter hypermethylation of the AE2/SLC4A2 gene in PBC (2019)

Primary biliary cholangitis (PBC) is a chronic immuneassociated cholestatic liver disease with unclear complex/multifactorial etiopathogenesis affecting mostly&#13;\nmiddle-aged women. Patients with PBC exhibit&#13;\nreduced expression of the AE2/SLC4A2 gene. Herein,&#13;\nwe found that AE2 promoter regions are hypermethylated in the liver and peripheral blood mononuclear&#13;\ncells of patients with PBC. This increased methylation&#13;\nis associated with downregulated AE2-gene expression, which might contribute to the pathogenesis of&#13;\nPBC. Therefore, novel epigenetic targets may improve&#13;\ntreatment in patients with PBC who respond poorly to&#13;\ncurrent pharmacological therapies.
Preclinical evaluation of the imipridone family, analogs of clinical stage anti-cancer small molecule ONC201, reveals potent anti-cancer effects of ONC212 (2017)

Anti-cancer small molecule ONC201 upregulates the integrated stress response (ISR) and acts as a dual inactivator of Akt/ERK, leading to TRAIL gene activation. ONC201 is under investigation in multiple clinical trials to treat patients with cancer. Given the unique imipridone core chemical structure of ONC201, we synthesized a series of analogs to identify additional compounds with distinct therapeutic properties. Several imipridones with a broad range of in vitro potencies were identified in an exploration of chemical derivatives. Based on in vitro potency in human cancer cell lines and lack of toxicity to normal human fibroblasts, imipridones ONC206 and ONC212 were prioritized for further study. Both analogs inhibited colony formation, and induced apoptosis and downstream signaling that involves the integrated stress response and Akt/ERK, similar to ONC201. Compared to ONC201, ONC206 demonstrated improved inhibition of cell migration while ONC212 exhibited rapid kinetics of activity. ONC212 was further tested in >1000 human cancer cell lines in vitro and evaluated for safety and anti-tumor efficacy in vivo. ONC212 exhibited broad-spectrum efficacy at nanomolar concentrations across solid tumors and hematological malignancies. Skin cancer emerged as a tumor type with improved efficacy relative to ONC201. Orally administered ONC212 displayed potent anti-tumor effects in vivo, a broad therapeutic window and a favorable PK profile. ONC212 was efficacious in vivo in BRAF V600E melanoma models that are less sensitive to ONC201. Based on these findings, ONC212 warrants further development as a drug candidate. It is clear that therapeutic utility extends beyond ONC201 to include additional imipridones.
Distinct hyperexcitability mechanisms underlie fast ripples and epileptic spikes (2011)

This study provides insights into the interpretation of 2 interictal markers observed in intracerebral electroencephalographic data. Depending on the degree and spatiotemporal features of hyperexcitability, not only IESs or FRs are generated but also transitions between both types of events.
Quantitative analysis of high-resolution, contrast-enhanced, cone-beam CT for the detection of intracranial in-stent hyperplasia (2014)

C-arm VasoCT is a high-resolution 3D capable imaging technique that has been validated in an animal model for measurement of in-stent tissue growth. Successful clinical implementation of the protocol was performed in a small case series.
Adsorption of Binary Gas Mixtures in Heterogeneous Carbon Predicted by Density Functional Theory: On the Formation of Adsorption Azeotropes (2010)

Classical density functional theory (DFT) was used to predict the adsorption of nine different binary gas mixtures in a heterogeneous BPL activated carbon with a known pore size distribution (PSD) and in single, homogeneous, slit-shaped carbon pores of different sizes. By comparing the heterogeneous results with those obtained from the ideal adsorbed solution theory and with those obtained in the homogeneous carbon, it was determined that adsorption nonideality and adsorption azeotropes are caused by the coupled effects of differences in the molecular size of the components in a gas mixture and only slight differences in the pore sizes of a heterogeneous adsorbent. For many binary gas mixtures, selectivity was found to be a strong function of pore size. As the width of a homogeneous pore increases slightly, the selectivity for two different sized adsorbates may change from being greater than unity to less than unity. This change in selectivity can be accompanied by the formation of an adsorption azeotrope when this same binary mixture is adsorbed in a heterogeneous adsorbent with a PSD, like in BPL activated carbon. These results also showed that the selectivity exhibited by a heterogeneous adsorbent can be dominated by a small number of pores that are very selective toward one of the components in the gas mixture, leading to adsorption azeotrope formation in extreme cases.
Neuroprotective and neurorestorative effects of thymosin β4 treatment initiated 6 hours after traumatic brain injury in rats (2012)

Thymosin β4 treatment initiated 6 hours postinjury provides both neuroprotection and neurorestoration after TBI, indicating that Tβ4 has promising therapeutic potential in patients with TBI. These data warrant further investigation of the optimal dose and therapeutic window of Tβ4 treatment for TBI and the associated underlying mechanisms.
Substrate Specificity of Aqualysin I, a Bacterial Thermophilic Alkaline Serine Protease fromThermus aquaticusYT-1: Comparison with Proteinase K, Subtilisin BPN′ and Subtilisin Carlsberg (1998)

Aqualysin I is the alkaline serine protease isolated from an extreme thermophile, Thermus aquaticus YT-1. We analyzed kinetic properties of aqualysin I, using sixteen kinds of chromogenic succinyl-tripeptide p-nitroanilides as substrates. And we compared the substrate specificity of aqualysin I with those of proteinase K, subtilisin BPN', and subtilisin Carlsberg. We found that aqualysin I had three subsites, S1, S2, and S3, in the substrate binding site. S1 site preferred alanine and phenylalanine. S2 site preferred alanine and norleucine. And S3 site preferred phenylalanine and isoleucine. These specificities were similar to those of proteinase K and subtilisin BPN'. The specificity of subtilisin Carlsberg differed from those of other enzymes.
Steep-fronted switching voltage transients and their distribution in motor windings. Part 1: System measurements of steep-fronted switching voltage transients (1982)

Insulation failure in motor windings can be caused by interturn breakdown resulting from stresses generated by steep-fronted transient voltages. The production and severity of such transients and degree of voltage stress on the motor-winding insulation is governed by the characteristics of the overall system to which the motor is connected. The investigations described in this paper cover extensive tests carried out at two large offshore oil production/water injection installations on a number of high-voltage motor circuits where motor failures had occurred. In particular, the tests were made to determine not only the nature and severity of the switching transients but also to determine the system characteristics governing their steepness and amplitude. For this purpose, the test programme included circuit-breaker timing tests, recurrent surge tests and synthetic tests in addition to full energisation tests. The results obtained and presented indicate that although, in all the circuits studied, steep-fronted transients are produced – in certain circuits, the amplitude of the transient would be sufficient to cause severe interturn insulation stresses in the motor winding. The system parameters that define the steepness of the transients and the combination of parameters that give rise to high-amplitude transients are evaluated. Tests with capacitors connected to the motor-winding terminals, to extend the wavefront duration of the transient voltages reaching the motor winding, are also described and discussed.