gebhart/patrepeval huggingface dataset:
Evaluation of a New Chemotherapeutic Agent in Patients with "Advanced Refractory" Acute Leukemia. Studies of 6-Azauracil (1960)

Abstract 6-Azauracil was studied in patients with "advanced" acute leukemia, refractory to standard chemotherapy. Under the conditions of the study this compound was found to have no significant antileukemic activity. As a result, these data have defined the natural history of this phase of acute leukemia. A significant proportion (30 per cent) of these patients showed objective hematologic improvement even in the absence of effective specific therapy, which might be ascribed to a prospective new agent. The median survival from the onset of the study of this group of patients was two months, and survival patterns for adults and children were similar.
Melody-coded fuzzy instructions containing time-depth implications for use in a drive-assistance system (2016)

A method of presenting fuzzy instructions in the form of melodious sounds that contain information on the manipulation of inputs over a certain period of time, rather than instantaneous information, is proposed for supporting a human operator who is handling a dynamic system. Such information suggests proper input transitions with fuzzy membership values and is presented in the form of instinctive melodious expressions composed based on functional harmonies. As an important example, the proposed method is applied to a drive-assistance system for an electric train system, and simulation runs are conducted to demonstrate its effective performance.
Semantic Interoperability and Integration (2004)

From 19.09.04 to 24.09.04, the Dagstuhl Seminar 04391 Semantic Interoperability and Integration was held in the International Conference and Research Center (IBFI), Schloss Dagstuhl. During the seminar, several participants presented their current research, and ongoing work and open problems were discussed. Abstracts of the presentations given during the seminar as well as abstracts of seminar results and ideas are put together in this paper. The rst section describes the seminar topics and goals in general. Links to extended abstracts or full papers are provided, if available.
Surface deformation using the sensor glove (1997)

Intuitive 30 sulfate control and deformation are czucial to CAD/CAM. To do this in a virtual environment, however, the tecZznique must be very efficient. A common method for shape deformation is the free-form deformation (FFD) method, in which the complete object is deformed by defozming a 30 grid of the object. In this paper, we propose an intuitive method for sulfate deformation based on deforming a hand s&ace, which is basically a bicubic B-spline sudace interpolating or approximating key data points of a sensor glove (i.e. finger joints and palm center of the user's hand). By setting up a corresponding mapping between the virtual object being deformed and the hand sugace, the object can be deformed with tlze control of the sensor glove. As the usersexes hislherfingers, the object changes its shape accordingly. Such control can be local or global. For local deformation, we introduce a region jilter function which imposes locality on the mapping/deformation. The new algorithm is made very efficient tlzrough incremental update. It is also intuitive as zfthe zzser were using his hand to deform the object directly. Experimental results show the potential of the new method.
Portal and pancreatic vein catheterization with radioimmunologic determination of insulin. (1975)

Percutaneous transhepatic catheterization of the portal vein along with the catheterization of the aorta and the vena cava was performed in six patients, one of whom had hypoglycemic attacks due to Whipple's triad. Blood samples from different branches in the different vessel systems were withdrawn for radioimmunologic determination of insulin. By this method, preoperative localization of the insulin producing pancreatic islet cell tumor was su-cessfully performed. Multiple tumors as well as liver metastases were preoperatively excluded. Recatheterization and blood sampling for radioimmunologic determination of insulin was performed postoperatively to verify the radicality of the operation. Insulin concentrations from the hypoglycemic patients were compared with those of the patients without insulinoma and found to be significantly higher. The procedure is proposed as a useful method for localizing all types of gastrointestinal hormone producing primary or secondary tumors in which a method for hormone determination is available. The postoperative investigation is useful as a check of the operation performed and as a follow-up examination for the early diagnosis of recurrence.
Table of Contents Internat I onal Journal of Informat I on Secur I ty and Pr I vacy (2009)

aBstraCt The security of computer systems that store our data is a major issue facing the world. This research project investigated the roles of ease of use, facilitating conditions, intention to use passwords securely, experience and age on usage of passwords, using a model based on the Unified Theory of Acceptance and Use of Technology. Data was collected via an online survey of computer users, and analyzed using PLS. The results show there is a significant relation -ship between ease of use of passwords, intention to use them securely and the secure usage of passwords. Despite expectations, facilitating conditions only had a weak impact on intention to use passwords securely and did not influence actual secure usage. Computing experience was found to have an effect on intention to use passwords securely, but age did not. The results of this research lend themselves to assisting in policy design and better understanding user behavior. [Article copies are available for purchase from InfoSci-on-Demand.com]Keywords: Ease of Use; Facilitating Conditions; Passwords; Unified Theory of Acceptance
High-NA fiber point-diffraction interferometer for three-dimensional coordinate measurement (2014)

The numerical aperture (NA) and power of diffraction wave in point-diffraction interferometer (PDI) could significantly limit the measurement range of the system. A fiber point-diffraction interferometer with high NA is proposed for the measurement of absolute three-dimensional coordinates. Based on the single-mode fiber with submicron aperture, the diffraction wave with both high NA and high power is obtained, by which the achievable measurement range of the PDI can be extended. A double-iterative method based on Levenbery-Marquardt algorithm is proposed to determine the three-dimensional coordinates under measurement. Numerical simulation and comparison experiments have been carried out to demonstrate the accuracy and feasibility of the proposed PDI system, with both high measurement precision and nice repeatability achieved.
Satellite Hardware (2010)

Irrespective of the intended application, be it a communications satellite or a weather forecasting satellite or even a remote sensing satellite, different subsystems comprising a typical satellite include the following: mechanical structure, propulsion subsystem, payload subsystem and Antenna subsystem. The mechanical structure that holds the satellite and links it to the launcher is very important. Some of the important design considerations that need to be addressed while designing the mechanical structure of the satellite are briefly described in this chapter. The propulsion subsystem is used to provide the thrusts required to impart the necessary velocity changes to execute all the manoeuvres during the lifetime of the satellite. The thermal control system maintains the satellite platform within its operating temperature limits for the type of equipment on board. The power supply subsystem generates, stores, controls and distributes electrical power to other subsystems on board the satellite platform. Controlled Vocabulary Terms planetary satellites; remote sensing; satellite communication; weather forecasting
Reactions of denatured proteins with other cellular components to form insoluble aggregates and protection by lactoferrin (1998)

Elucidation of the mechanism of formation of insoluble protein aggregates is essential to resolve problems such as protein folding diseases. In this study the effects of various types of biomolecules on the aggregation of denatured proteins were investigated. Denatured alpha-lactalbumin, an acidic protein, was found to be precipitated by lactoferricin, a basic peptide derived from lactoferrin. Denatured lysozyme, a basic protein, by itself showed aggregation, which was promoted by addition of native alpha-lactalbumin. Heparin and nucleic acids caused almost instant aggregation of denatured lysozyme. Native lactoferricin was also found to aggregate with heparin or nucleic acids. The results show that denatured/misfolded proteins as well as peptides are highly reactive with other cellular components to form insoluble aggregates and suggest a possible mechanism by which protein folding diseases progress. Most of the above aggregation reactions were inhibited by lactoferrin, which could form soluble complexes with denatured alpha-lactalbumin, heparin, and nucleic acids.
Flow Guided Recurrent Neural Encoder for Video Salient Object Detection (2018)

Image saliency detection has recently witnessed significant progress due to deep convolutional neural networks. However, extending state-of-the-art saliency detectors from image to video is challenging. The performance of salient object detection suffers from object or camera motion and the dramatic change of the appearance contrast in videos. In this paper, we present flow guided recurrent neural encoder (FGRNE), an accurate and end-to-end learning framework for video salient object detection. It works by enhancing the temporal coherence of the per-frame feature by exploiting both motion information in terms of optical flow and sequential feature evolution encoding in terms of LSTM networks. It can be considered as a universal framework to extend any FCN based static saliency detector to video salient object detection. Intensive experimental results verify the effectiveness of each part of FGRNE and confirm that our proposed method significantly outperforms state-of-the-art methods on the public benchmarks of DAVIS and FBMS.
A Quantitative, Qualitative, and Critical Assessment of Surgical Waste (1992)

<h3>Objectives.</h3> —To quantitatively and qualitatively evaluate the surgical waste produced from several common surgical procedures, define categories of waste that might be readily separated for alternative disposal practices or substitution, and determine the change in surgical waste output that elimination or alternative handling methods may effect. <h3>Design.</h3> —A case series evaluating the surgical waste from five types of surgical procedures including operations of the back, heart, abdomen, hip and knee, and herniorrhaphies, prospectively identified and allocated at the availability of the investigator. <h3>Setting.</h3> —A single tertiary community teaching hospital. <h3>Outcome Measures.</h3> —Weight, volume, and percentage of disposable linen, paper, and plastic plus miscellaneous material from surgical waste with a later subset separating plastics from miscellaneous items to completely identify all categories. <h3>Results.</h3> —Surgical waste weighing 610.5 lb (274.7 kg) and occupying 171.6 cu ft (5.1 m<sup>3</sup>) from 27 cases was examined. Disposable linens accounted for 39% of the weight; paper, 7%; plastic, 26%; and miscellaneous waste, 27%. By volume, disposable linen and paper accounted for 69%; plastic, 23%; and miscellaneous waste, 7%. Disposable linen, paper, and recyclable plastic accounted for 73±7% (mean±SD) by weight and 93%±4% by volume of total surgical waste. <h3>Conclusion.</h3> —Nationally, annual surgical waste from these five procedures weighs 5.1×10<sup>7</sup>lb (2.3×10<sup>7</sup>kg) and occupies 1.4×10<sup>7</sup>cu ft (4.0×10<sup>5</sup>m<sup>3</sup>). By using reusable linen products and engaging in recycling methods currently available and feasible, we estimate that weight reductions of 73% and volume reductions of 93% in surgical waste are possible. (<i>JAMA</i>. 1992;267:2765-2768)
The VSOP 5 GHz AGN Survey I. Compilation and Observations (2000)

The VSOP mission is a Japanese-led project to image radio sources with sub-milliarcsec resolution by correlating the signal from the orbiting 8-m telescope, HALCA, with a global array of telescopes. Twenty-five percent of the scientific time of this mission is devoted to a survey of 402 bright, small-diameter extra-galactic radio sources at 5 GHz. The major goals of the VSOP Survey are statistical in nature: to determine the brightness temperature and approximate structure; to provide a source list for use with future space VLBI missions; and to compare radio properties with other data throughout the EM spectrum. This paper describes: the compilation of a complete list of radio sources associated with active galactic nuclei (AGN); the selection of the subsample of sources to be observed with VSOP; the extensive ground resources used for the Survey; the status of the observations as of 2000 July; the data-analysis methods; and several examples of results from the VSOP Survey. More detailed results from the full sample will be given in future papers.
Supplementary method from LSR Antibody Therapy Inhibits Ovarian Epithelial Tumor Growth by Inhibiting Lipid Uptake (2023)

&lt;p&gt;This article shows how to product anti-LSR antibody&lt;/p&gt;
Mechanism of CO2 Capture and Release on Redox-Active Organic Electrodes (2023)

The mechanism of faradaic electro-swing for CO2 capture/release on a redox-active organic electrode is studied from the point of view of realizing a reversible process for CO2 separation. First, the cyclic voltammograms (CVs) of two redox-active organic monomers, anthraquinone (AQ) and 2,1,3-benzothiadiazole (BTZ), were measured under a CO2 atmosphere. The waveforms of CVs of the two redox-active organic monomers are altered under a CO2 atmosphere relative to a N2 atmosphere. There is a change in the number of redox waves from two to one for AQ and a change from reversible to irreversible waves for BTZ. To further understand the mechanisms of CO2 capture/release on redox-active organic compounds, redox-active polymer electrodes coated with polyanthraquinone (PAQ) and polybenzothiadiazole (PBTZ) were investigated using a spectroscopic analysis known as in situ attenuated total reflectance–surface-enhanced infrared absorption spectroscopy (ATR–SEIRAS) as well as density functional theory (DFT) calculations. The CVs measured with two redox-active polymer electrodes have more positive shifts of reduction potentials for PAQ and PBTZ under a CO2 atmosphere than under an N2 atmosphere, as measured versus Ag/AgNO3: −1.8 and −1.4 V → −1.4 and −0.9 V for PAQ and −2.5 V → −2.1 and −1.9 V for PBTZ. In addition, the oxidation current on the PBTZ electrode disappears only under a CO2 atmosphere. DFT calculations indicate that the positive shifts of reduction potentials in the two electrodes under CO2 conditions are due to an exergonic adsorption reaction of CO2 onto the redox-active organic compounds. To clarify the reaction behavior between CO2 and the redox-active organic electrode, an ATR–SEIRAS spectroscopic analysis was performed. Infrared peaks are observed at 2200 and 2100 cm–1 for PAQ and PBTZ electrodes, respectively, under a CO2 atmosphere, which have been confirmed by measurements under a 13CO2 atmosphere to have adsorbed CO2. The wavenumbers corresponding to the CO2 molecules adsorbed on the two electrodes are different. These findings indicate that one electron reduction and CO2 adsorption for each redox-active organic compound are occurring simultaneously. The calculated adsorption energy of CO2 for two redox-active organic electrodes indicates that the adsorption energies of two CO2 molecules for AQ and BTZ are −7.3 and −36.3 kJ/mol. The larger adsorption energy in BTZ than that in AQ is clearly related to the disappearance of the oxidation current. However, both adsorption energies indicating adsorption of CO2 onto organic units are less than the covalent bond energies of common organic compounds, indicating that such weak adsorptions are suitable for the faradaic electro-swing of CO2 capture/release on the redox-active organic units.
Hormonal Effects of Ketoconazolein Vivoin the Male Rat: Mechanism of Action* (1986)

Ketoconazole, an antifungal agent, has been shown to lower serum testosterone (T) in man. Measurements of circulating precursors of T suggest that ketoconazole may inhibit 17,20-desmolase activity in the testis. To further elucidate its mechanism of action in vivo, we studied its effects on the pituitary-gonadal axis in the male rate. Two groups of normal male Sprague-Dawley rats were treated with either oil or 25 mg ketoconazole in oil by im injection every 8 h for 21 days. Serum ketoconazole concentrations in the rat 2 h after the 25-mg dose were similar to those after oral administration of a much lower (1/33rd) dose to man. Ketoconazole treatment led to 50% suppression of serum T and prostate and seminal vesicle weights. Testis weights were not significantly affected. Intratesticular T concentrations showed a 50% decrease below the control level. Testicular 17 alpha-hydroxylase, 17,20-desmolase, and 17 beta-hydroxysteroid dehydrogenase activities in the ketoconazole-treated animals were significantly decreased in proportion to the decreases in serum and intratesticular T concentrations. Elevations of serum LH and FSH concentrations in the ketoconazole-treated rats were not proportionate to the decline in serum T concentration. Therefore, to exclude an additional inhibitory effect of ketoconazole at the pituitary level, we treated two groups of castrated male Sprague-Dawley rats with the same dose of ketoconazole or oil for 3 days. Serum LH and FSH concentrations were not significantly different in the two groups. In separate experiments, combined treatment of intact rats with GnRH agonist and ketoconazole for 21 days led to lower mean serum T concentrations and accessory organ weights than those achieved with either agent alone. We conclude that ketoconazole inhibits T synthesis, primarily by inhibiting the activity of multiple enzymes in the T biosynthetic pathway and has no direct effect at the pituitary level; ketoconazole metabolism in the rat is considerably different from that in man; and ketoconazole enhances the inhibitory effects of GnRH agonist.
MiR‐221 promotes cardiac hypertrophy in vitro through the modulation of p27 expression (2012)

Cardiac hypertrophy has been known as an independent predictor for cardiovascular morbidity and mortality. Molecular mechanisms underlying the development of heart failure remain elusive. Recently, microRNAs (miRs) have been established as important regulators in cardiac hypertrophy. Here, we reported miR-221 was up-regulated in both transverse aortic constricted mice and patients with hypertrophic cardiomyopathy (HCM). Forced expression of miR-221 by transfection of miR-221 mimics increased myocyte cell size and induced the re-expression of fetal genes, which were inhibited by the knockdown of endogenous miR-221 in cardiomyocytes. The TargetScan algorithm-based prediction identified that p27, a cardiac hypertrophic suppressor, is the putative target of miR-221, which was confirmed by luciferase assay and Western blotting. In conclusion, our results demonstrated that miR-221 regulated cardiomyocyte hypertrophy probably through down-regulation of p27, suggesting that miR-221 may be a new intervention target for cardiac hypertrophy.
Bayesian <inline-formula> <tex-math notation="LaTeX">$M$ </tex-math> </inline-formula>-Ary Hypothesis Testing: The Meta-Converse and Verdú-Han Bounds Are Tight (2016)

Two alternative exact characterizations of the minimum error probability of Bayesian M-ary hypothesis testing are derived. The first expression corresponds to the error probability of an induced binary hypothesis test and implies the tightness of the meta-converse bound by Polyanskiy et al.; the second expression is a function of an information-spectrum measure and implies the tightness of a generalized Verdú-Han lower bound. The formulas characterize the minimum error probability of several problems in information theory and help to identify the steps where existing converse bounds are loose.
Competition between zidovudine-sensitive and zidovudine-resistant strains of HIV (1992)

Although resistant strains are observed after prolonged treatment with zidovudine, this model suggests that it is the growing supply of uninfected CD4+ cells which causes the eventual upsurge in viral burden.
System components for embedded information retrieval from multiple disparate information sources (1993)

Current information retrieval interfaces only address a small pant of the reality of rich interactions amongst user, task, and information sources. We view information gathering as an interactive, iterative activity involving multiple disparate information sources and embedded in the context of broader processes of information use. We have developed two key system components that enable information workspaces that adhere to this reformulation of information retrieval.
SIGNAL SEQUENCES FOR EARLY EVENTS IN PROTEIN SECRETION AND MEMBRANE ASSEMBLY (1980)

Signal sequences for the transfer of proteins across membranes are usually found at the NH2-terminus of nascent secretory and transmembrane proteins. The functionally equivalent signal sequence of chicken ovalbumin however, is localized in the middle of the molecule. The implication of this surprising finding for biogenesis of membrane proteins is discussed.
Data from BAP1 Loss Is Associated with DNA Methylomic Repatterning in Highly Aggressive Class 2 Uveal Melanomas (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;The strong association between &lt;i&gt;BAP1&lt;/i&gt; mutations and metastasizing Class 2 uveal melanoma (UM) suggests that epigenetic alterations may play a significant role in tumor progression. Thus, we characterized the impact of &lt;i&gt;BAP1&lt;/i&gt; loss on the DNA methylome in UM.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Global DNA methylation was analyzed in 47 Class 1 and 45 Class 2 primary UMs and in UM cells engineered to inducibly deplete BAP1. RNA-Seq was analyzed in 80 UM samples and engineered UM cells.&lt;/p&gt;Results:&lt;p&gt;Hypermethylation on chromosome 3 correlated with downregulated gene expression at several loci, including 3p21, where &lt;i&gt;BAP1&lt;/i&gt; is located. Gene set analysis of hypermethylated and downregulated genes identified axon guidance and melanogenesis as deregulated pathways, with several of these genes located on chromosome 3. A novel hypermethylated site within the &lt;i&gt;BAP1&lt;/i&gt; locus was found in all Class 2 tumors, suggesting that &lt;i&gt;BAP1&lt;/i&gt; itself is epigenetically regulated. Highly differentially methylated probes were orthogonally validated using bisulfite sequencing, and they successfully distinguished Class 1 and Class 2 tumors in 100% of cases. In functional validation experiments, &lt;i&gt;BAP1&lt;/i&gt; knockdown in UM cells induced methylomic repatterning similar to UM tumors, enriched for genes involved in axon guidance, melanogenesis, and development.&lt;/p&gt;Conclusions:&lt;p&gt;This study, coupled with previous work, suggests that the initial event in the divergence of Class 2 UM from Class 1 UM is loss of one copy of chromosome 3, followed by mutation of &lt;i&gt;BAP1&lt;/i&gt; on the remaining copy of chromosome 3, leading to the methylomic repatterning profile characteristic of Class 2 UMs.&lt;/p&gt;&lt;/div&gt;