gebhart/patrepeval huggingface dataset:
THE CLINICAL SIGNIFICANCE OF ANTIBODIES TO HUMAN VASCULAR ENDOTHELIAL CELLS AFTER CARDIAC TRANSPLANTATION1 (1999)

AECA may be important in the mediation of humoral AR, may decrease allograft survival, and may identify a high-risk group for CAV.
Supplementary Figure Legend from The HER2- and Heregulin β1 (HRG)–Inducible TNFR Superfamily Member Fn14 Promotes HRG-Driven Breast Cancer Cell Migration, Invasion, and MMP9 Expression (2023)

&lt;p&gt;PDF file - 103K&lt;/p&gt;
Ultra-Low Noise Balanced Receiver with >20 dB Quantum-to-Classical Noise Clearance at 1 GHz (2021)

We demonstrate a die-level balanced homodyne receiver for coherent optical access and continuous-variable quantum applications, featuring a 40dB CMRR up to 1GHz and a high quantum-to-classical noise ratio of 26.8dB at 12.3mW of LO power. 500Mb/s QPSK transmission was accomplished with a sensitivity of -55.8dBm.
Long-term administration of L-arginine improves nitric oxide release from kidney in deoxycorticosterone acetate-salt hypertensive rats. (1994)

To examine the effects of L-arginine (L-Arg) on endothelial function, we administered 0.5 g/L L-Arg in drinking water to deoxycorticosterone acetate (DOCA)-salt rats for 8 weeks and then measured nitric oxide (NO) release from isolated kidneys using a newly developed real-time chemiluminescence method. Renal pathology was also analyzed. Acetylcholine caused much smaller declines in renal perfusion pressure (10(-7) mol/L acetylcholine: -24 +/- 2% [SEM] versus -50 +/- 2%, P < .001) and NO release in DOCA-salt rats (+3 +/- 1 versus +33 +/- 3 fmol/min per gram kidney weight, P < .001) compared with control rats. L-Arg did not influence the time course of systolic blood pressure elevation in DOCA-salt rats (211 +/- 5 versus 208 +/- 6 mmHg, DOCA versus L-Arg/DOCA, P = NS). However, oral administration of L-Arg improved acetylcholine-induced declines in renal perfusion pressure (10(-7) mol/L acetylcholine: L-Arg/DOCA, -39 +/- 3%, P < .01 versus DOCA). This change was associated with an increase in NO release by acetylcholine (10(-7) mol/L acetylcholine: L-Arg/DOCA, +10 +/- 1 fmol/min per gram kidney weight, P < .05 versus DOCA). However, morphological changes in renal vessels and glomeruli were similar between DOCA and L-Arg/DOCA rats. These results suggest that L-Arg administration partially reverses renal endothelial function with respect to vasorelaxation and NO release independent of blood pressure changes, indicating that hypertensive vessels seem to be depleted of L-Arg and/or have defects in the availability of L-Arg for NO synthesis.
PBL in the space-time continuum for engineering education (2022)

This article presents how Problem- and Project-Based Learning (PBL) in engineering education can exploit the theoretical framework of the Space–Time (ST)-Continuum, according to which educational contexts can be classified in terms of the tightness vs. looseness of the relevant conceptual space S and available time T. By crossing these two dimensions, four quadrants are obtained in the ST-Continuum: tight space and tight time, loose space and tight time, tight space and loose time, loose space and loose time. Different pedagogies are adaptive to different quadrants. We show how PBL can be mapped onto the ST-Continuum depending on the context characteristics or the chosen problem or project. Further, this article discusses how the intelligence and creativity constructs can be developed through diverse educational scenarios, giving examples of PBL interventions that can be located in different quadrants. Moreover, the analysis shows how through suitable planning, it is possible to have educational activities that consider all the quadrants of the ST-Continuum, even in traditional education curricula or teacher-centered approaches. Finally, the article discusses how teaching practices can promote intelligence and creativity in the curricula at different PBL organisational levels depending on their relationship with the ST-Continuum.
Targeted Delivery of a γ-Glutamyl Transpeptidase Activatable Near-Infrared-Fluorescent Probe for Selective Cancer Imaging (2018)

The noninvasive and specific detection of cancer cells in living subjects has been essential for the success of cancer diagnoses and treatments. Herein, we report a strategy of combining an α<sub>v</sub>β<sub>3</sub>-integrin-receptor-targetable ligand, c-RGD, with the γ-glutamyl transpeptidase (GGT)-recognizable substrate, γ-glutamate (γ-Glu), to develop a tumor-targeting and GGT-activatable near-infrared (NIR)-fluorescent probe for the noninvasive imaging of tumors in living mice. We demonstrated that the probe's fluorescence was off initially, but when the γ-Glu in the probe was specifically cleaved by GGT, the fluorescent product was released and could be selectively taken up by U87MG-tumor cells via α<sub>v</sub>β<sub>3</sub>-receptor-mediated endocytosis. Remarkably, enhanced intracellular NIR fluorescence distributed mainly in the lysosomes was observed in the tumor cells only, showing that the probe was capable of differentiating the tumor cells from the GGT-positive, α<sub>v</sub>β<sub>3</sub>-deficient normal cells. Moreover, the probe also showed a high selectivity for the real-time and noninvasive detection of GGT activity in xenograft U87MG tumors following iv administration. This study reveals the advantage of using a combination of receptor-mediated cell uptake and molecular-target-triggered activation to design molecular probes for improved cancer imaging, which could facilitate effective cancer diagnoses.
A highly granular SiPM-on-tile calorimeter prototype (2019)

The Analogue Hadron Calorimeter (AHCAL) developed by the CALICE collaboration is a scalable engineering prototype for a Linear Collider detector. It is a sampling calorimeter of steel absorber plates and plastic scintillator tiles read out by silicon photomultipliers (SiPMs) as active material (SiPM-on-tile). The front-end chips are integrated into the active layers of the calorimeter and are designed for minimizing power consumption by rapidly cycling the power according to the beam structure of a linear accelerator. 38 layers of the sampling structure are equipped with cassettes containing 576 single channels each, arranged on readout boards and grouped according to the 36 channel readout chips. The prototype has been assembled using techniques suitable for mass production, such as injection-moulding and semi-automatic wrapping of scintillator tiles, assembly of scintillators on electronics using pickand-place machines and mass testing of detector elements. The calorimeter was commissioned at DESY and was taking data at the CERN SPS at the time of the conference. The contribution discusses the construction, commissioning and first test beam results of the CALICE AHCAL engineering prototype.
Metal−Metal Interactions in Dinuclear d8 Metal Cyanide Complexes Supported by Phosphine Ligands. Spectroscopic Properties and ab Initio Calculations of [M2(μ-diphosphine)2(CN)4] and trans-[M(phosphine)2(CN)2] (M = Pt, Ni) (2002)

Structural, spectroscopic properties on the dinuclear [M(2)(dcpm)(2)(CN)(4)] (M = Pt, 1a; Ni, 2a, dcpm = bis(dicyclohexylphosphino)methane) and [M(2)(dmpm)(2)(CN)(4)] (M = Pt, 1b; Ni, 2b, dmpm = bis(dimethylphosphino)methane) and the mononuclear trans-[M(PCy(3))(2)(CN)(2)] (M = Pt, 3; Ni, 4, PCy(3) = tricyclohexylphosphine) and theoretical investigations on the corresponding model compounds are described. X-ray structural analyses reveal Pt.Pt and Ni.Ni distances of 3.0565(4)/3.189(1) A and 2.957(1)/3.209(8) A for 1a/1b and 2a/2b, respectively. The UV-vis absorption bands at 337 nm (epsilon 2.41 x 10(4) dm(3) mol(-)(1) cm(-)(1)) for 1a and 328 nm (epsilon 2.43 x 10(4) dm(3) mol(-)(1) cm(-)(1)) for 1b in CH(2)Cl(2) are assigned to (1)(5d(sigma) --> 6p(sigma)) electronic transitions originating from Pt(II)-Pt(II) interactions. Resonance Raman spectroscopy of 1a, in which all the Raman intensity appears in the Pt-Pt stretch fundamental (93 cm(-)(1)) and overtone bands, verifies this metal-metal interaction. Complexes 1a and 1b exhibit photoluminescence in the solid state and solution. For the dinuclear nickel(II) complexes 2a and 2b, neither spectroscopic data nor theoretical calculation suggests the presence of Ni(II)-Ni(II) interactions. The intense absorption bands at lambda > 320 nm in the UV-vis spectra of 2a and 2b are tentatively assigned to d --> d transitions.
Marine alkaloid monanchoxymycalin C: a new specific activator of JNK1/2 kinase with anticancer properties (2020)

Monanchoxymycalin C (MomC) is a new marine pentacyclic guanidine alkaloid, recently isolated from marine sponge Monanchora pulchra by us. Here, anticancer activity and mechanism of action was investigated for the first time using a human prostate cancer (PCa) model. MomC was active in all PCa cell lines at low micromolar concentrations and induced an unusual caspase-independent, non-apoptotic cell death. Kinase activity screening identified activation of mitogen-activated protein kinase (MAPK) c-Jun N-terminal protein kinase (JNK1/2) to be one of the primary molecular mechanism of MomC anticancer activity. Functional assays demonstrated a specific and selective JNK1/2 activation prior to the induction of other cell death related processes. Inhibition of JNK1/2 by pretreatment with the JNK-inhibitor SP600125 antagonized cytotoxic activity of the marine compound. MomC caused an upregulation of cytotoxic ROS. However, in contrast to other ROS-inducing agents, co-treatment with PARP-inhibitor olaparib revealed antagonistic effects indicating an active PARP to be necessary for MomC activity. Interestingly, although no direct regulation of p38 and ERK1/2 were detected, active p38 kinase was required for MomC efficacy, while the inhibition of ERK1/2 increased its cytotoxicity. In conclusion, MomC shows promising activity against PCa, which is exerted via JNK1/2 activation and non-apoptotic cell death.
Phase I study of 5-fluorouracil in children and young adults with recurrent ependymoma (2015)

These phase I clinical data provide initial pharmacokinetic parameters to describe i.v. bolus 5-FU disposition in children with recurrent ependymoma. Tumor exposures effective in preclinical testing can be achieved with tolerable bolus dosages in patients. Bolus 5-FU is well tolerated and possesses antitumor activity.
Application of the Anomeric Samarium Route for the Convergent Synthesis of theC-Linked Trisaccharide α-d-Man-(1→3)-[α-d-Man-(1→6)]-d-Man and the Disaccharides α-d-Man-(1→3)-d-Man and α-d-Man-(1→6)-d-Man (2002)

Studies are reported on the assembly of the branched C-trisaccharide, alpha-D-Man-(1-->3)-[alpha-D-Man-(1-->6)]-D-Man, representing the core region of the asparagine-linked oligosaccharides. The key step in this synthesis uses a SmI(2)-mediated coupling of two mannosylpyridyl sulfones to a C3,C6-diformyl branched monosaccharide unit, thereby assembling all three sugar units in one reaction and with complete stereocontrol at the two anomeric carbon centers. Subsequent tin hydride-based deoxygenation followed by a deprotection step produces the target C-trimer. In contrast to many of the other C-glycosylation methods, this approach employes intact carbohydrate units as C-glycosyl donors and acceptors, which in many instances parallels the well-studied O-glycosylation reactions. The synthesis of the C-disaccharides alpha-D-Man-(1-->3)-D-Man and alpha-D-Man-(1-->6)-D-Man is also described, they being necessary for the following conformational studies of all three carbohydrate analogues both in solution and bound to several mannose-binding proteins.
Available methane from anthracite by combining coal seam microflora andH2O2pretreatment (2020)

The conversion of coal to methane by anaerobic microorganisms is an efficient, clean, and green way to utilize coal. However, methane production is relatively low due to the low bioavailability of coal. H2O2 has been demonstrated to increase methane production by transferring coal to liquid organics. Little is known about the bioavailability of residual coal after H2O2 pretreatment. Here, H2O2 was employed to pretreat anthracite, and the potential of residual coal to produce methane was analyzed. The optimum conditions for pretreatment were 30% H2O2 for 12 hours when the methane production reached 254.97 μmol/g coal, increased by 24.98% compared with that in unpretreated coal. The results of FTIR showed that the substitutions of aromatics, alkanes rings, aliphatics, and even C=C structure in coal were depolymerized and oxygen-containing functional groups were generated after pretreatment with H2O2. The oxygen-containing functional groups were further degraded by anaerobic microflora. The XRD results showed that the crystal structure of coal decreased after pretreatment with H2O2 following 27 days of cultivation. These results suggested that H2O2 pretreatment mainly altered coal by increasing the oxygen-containing functional groups and decreasing the crystal structure of coal to facilitate coal biodegradation and enhance biomethane production. The effect of H2O2 on the production of biomethane was not only to produce easily degradable organics, but also to change the coal structure and promote the degradation of residual coal. Therefore, the enhancement of biomethane production by H2O2 pretreatment on surface bioconversion and underground coalbed methane mining should take the increase methane yield from residual coal into account.
Energy capacity reduction of energy storage system in microgrid by use of heat pump: Characteristic study by use of actual machine (2010)

The installation of renewable energy sources based generators such as photovoltaic cells and wind turbines require energy storage systems(ESSs) to control power fluctuation. ESSs, however, are quite expensive. In order to reduce the necessary capacity of ESSs for microgrid applications, the control of heat pumps is researched. In this research, basic characteristic of a heat pump's power consumption is measured experimentally by use of heat pump chiller unit used in real building. Using the measured characteristic, a method to reduce the energy capacity of ESS is proposed and studied. The capacity reduction of ESS that can be achieved by use of heat pump control and the effect of control on temperature were calculated using simulations.
Theory of carbon nanotube growth (1995)

The kinetics of carbon nanotube growth under arc discharge conditions were investigated over different length and time scales using complementary numerical techniques. Relaxation by ab initio molecular dynamics (Car-Parrinello method) shows that large electric fields present at the tube tips are not the critical factor responsible for the open-ended growth observed experimentally. Classical molecular-dynamics simulations using realistic many-body carbon-carbon potentials show that wide tubes that are initially open can continue to grow straight and maintain an all-hexagonal structure. However, tubes narrower than a critical diameter, estimated to be about \ensuremath{\sim}3 nm, readily nucleate curved, pentagonal structures that lead to tube closure with further addition of atoms. Very narrow tubes can be grown, however, if a small metal particle prevents tube closure. This effect was simulated explicitly by kinetic Monte Carlo methods. Monte Carlo simulations were also used to study nanotube growth over longer time scales. The resulting structures are in agreement with the above growth scenario, and provide an estimate for the lowest tube tip temperature necessary for the growth of nanotubes.
A Crystalline Organo-iron Pigment from a Rust Fungus (Ustilago sphaerogena)1 (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Crystalline Organo-iron Pigment from a Rust Fungus (Ustilago sphaerogena)1J. B. NeilandsCite this: J. Am. Chem. Soc. 1952, 74, 19, 4846–4847Publication Date (Print):October 1, 1952Publication History Published online1 May 2002Published inissue 1 October 1952https://pubs.acs.org/doi/10.1021/ja01139a033https://doi.org/10.1021/ja01139a033research-articleACS PublicationsRequest reuse permissionsArticle Views535Altmetric-Citations196LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A circuit and five probe resistivity method for measuring pulse I–V characteristics of superconductors (1994)

An electronic circuit has been developed to study the pulse I–V characteristics of superconductors. A special feature of the circuit is its low rms noise voltage of less than 10 nV, which allows measurements over a broad voltage range of 50 nV to 500 mV for the first time. In order to overcome the limitations of a four probe technique at high common mode voltages, a novel five probe geometry is developed. The measurements on single crystals of the Bi2Sr2CaCu2Ox superconductor are carried out to demonstrate the circuit performance.
Audio-Based Wildfire Detection on Embedded Systems (2022)

The occurrence of wildfires often results in significant fatalities. As wildfires are notorious for their high speed of spread, the ability to identify wildfire at its early stage is essential in quickly obtaining control of the fire and in reducing property loss and preventing loss of life. This work presents a machine learning wildfire detecting data pipeline that can be deployed on embedded systems in remote locations. The proposed data pipeline consists of three main steps: audio preprocessing, feature engineering, and classification. Experiments show that the proposed data pipeline is capable of detecting wildfire effectively with high precision and is capable of detecting wildfire sound over the forest’s background soundscape. When being deployed on a Raspberry Pi 4, the proposed data pipeline takes 66 milliseconds to process a 1 s sound clip. To the knowledge of the author, this is the first edge-computing implementation of an audio-based wildfire detection system.
Acknowledgement to Editors and Scientific Referees 2020 (2020)

A scientific journal’s greatest responsibility is to ensure that all contributions accepted for publications are rigorously but fairly reviewed. The Editor-in-Chief and Archives of Pediatric Neurosurgery gratefully acknowledge the qualified and regular collaboration of renowned medical doctors and scientists who kindly devoted their time to constructively review the submitted articles. Their expertise and invaluable assistance contributed to maintain a high scientific standard for APN. We are thus indebted to the Editorial Board members and the following experts who reviewed papers and completed the peer-reviewing process within 2020.
Mycobactericidal activity of bedaquiline plus rifabutin or rifampin in ex vivo whole blood cultures of healthy volunteers: A randomized controlled trial (2018)

The combination of rifabutin plus bedaquiline produces sustained intracellular mycobactericidal activity that is greater than the sum of their individual effects. Further studies of the treatment-shortening potential of this combination are warranted.
Post-transcriptional control of cellular differentiation by the RNA exosome complex (2020)

Given the complexity of intracellular RNA ensembles and vast phenotypic remodeling intrinsic to cellular differentiation, it is instructive to consider the role of RNA regulatory machinery in controlling differentiation. Dynamic post-transcriptional regulation of protein-coding and non-coding transcripts is vital for establishing and maintaining proteomes that enable or oppose differentiation. By contrast to extensively studied transcriptional mechanisms governing differentiation, many questions remain unanswered regarding the involvement of post-transcriptional mechanisms. Through its catalytic activity to selectively process or degrade RNAs, the RNA exosome complex dictates the levels of RNAs comprising multiple RNA classes, thereby regulating chromatin structure, gene expression and differentiation. Although the RNA exosome would be expected to control diverse biological processes, studies to elucidate its biological functions and how it integrates into, or functions in parallel with, cell type-specific transcriptional mechanisms are in their infancy. Mechanistic analyses have demonstrated that the RNA exosome confers expression of a differentiation regulatory receptor tyrosine kinase, downregulates the telomerase RNA component TERC, confers genomic stability and promotes DNA repair, which have considerable physiological and pathological implications. In this review, we address how a broadly operational RNA regulatory complex interfaces with cell type-specific machinery to control cellular differentiation.
Characterization of transgenic Arabidopsis plants overexpressing GR-RBP4 under high salinity, dehydration, or cold stress (2005)

A glycine-rich RNA-binding protein4 (GR-RBP4), one of the eight GR-RBP family members in Arabidopsis thaliana, was investigated for its stress-related expression, nucleic acid-binding property, and functional roles in plants subjected to various stresses including cold, high salinity, and dehydration. Real-time RT-PCR and GUS expression analyses showed that GR-RBP4 was abundantly expressed in young plants, root tips, and flowers, but weakly in mature leaves and stems, implying that GR-RBP4 is highly expressed in actively proliferating organs. The transcript level of GR-RBP4 increased markedly with cold stress, decreased significantly with salt stress, and decreased slightly with dehydration stress. In vitro nucleic acid-binding assays revealed that GR-RBP4 protein binds sequence non-specifically to RNAs and DNAs. Characterization of the transgenic Arabidopsis plants overexpressing GR-RBP4 under the control of the 35S promoter revealed that 35S::GR-RBP4 lines displayed retarded germination compared with the wild type under salt or dehydration stress. Despite the marked up-regulation of GR-RBP4 expression by cold stress, the 35S::GR-RBP4 lines did not show any noticeable changes in cold or freezing tolerance compared with wild-type plants. These results indicate that GR-RBP4 contributes differently to altered germination and seedling growth of Arabidopsis plants under various stress conditions.
Fast NIC-based barrier over Myrinet/GM (2002)

An efficient barrier implementation is desirable on parallel systems to obtain good parallel speedup and to support finer-grained computation. Some modern Network Interface Cards (NICs) have programmable processors which can be used to provide support for collective communications such as barrier In this paper we utilize such a programmable NIC to provide an efficient barrier synchronization operation. This paper describes the design, implementation and evaluation of a NIC-based barrier operation as an addition to Myricom's GM message passing system. Our NIC-based barrier implementation achieved a barrier latency of 102.14 /spl mu/s for 16 nodes which is a 1.78 factor of improvement over the host-based barrier using the same algorithm for LANai 4.3 NIC cards. Using LANai 7.2 cards, which has a faster processor, we achieved a 1.83 factor of improvement for eight nodes. Our NIC-based barrier operation promises scalable fine-grained parallel computation over clusters of workstations. To the best of our knowledge, this is the first NIC-level barrier implementation on a cluster with Myrinet/GM.