gebhart/patrepeval huggingface dataset:
Onconeural Versus Paraneoplastic Antigens? (2007)

A hallmark of naturally occurring tumor immunity is the aberrant expression of so called "onconeural antigens" or "paraneoplastic antigens". At present, these two terms are used as synonyms for proteins which are normally expressed only in neuronal tissues, but in the process of carcinogenesis, they can be detected in tumors located outside the nervous system. As neuronal tissues are immunopriveleged zones, expression of these proteins in tumor cells can induce an autoimmune response, which manifests in the generation of autoantibodies and/or specific cytotoxic T-cells. Whether or not such immune responses necessarily lead to paraneoplastic syndromes or to a beneficial antitumor response or both is not fully understood. In this review we comprehensively summarize recent literature on paraneoplastic antigens including the corresponding neurological syndromes. A unified classification is proposed with "onconeural antigens" as collective term and a number of subgroups including the recently discovered cancer-retina antigens. Certain onconeural antigens can serve as paraneoplastic antigens under conditions which have yet to be defined, implying that the paraneoplastic function is not inherent to the antigen. The potential of onconeural antigens in cancer diagnostics and treatment strategies is discussed.
vConductor: An NFV management solution for realizing end-to-end virtual network services (2014)

NFV, being discussed and standardized in ETSI, is regarded as a promising candidate technology for Future Networks. Although many advantages are expected, the introduction of NFV will greatly challenge current management systems. In this paper, we summarize some of the carrier's requirements for the management of NFV, based on which we propose vConductor as an NFV management solution. We say vConductor is innovative due to its characteristics of automatic service provisioning, end-to-end inventory management, and generic system design. To achieve these goals, we design a completely modular-based system structure and refine the process of provisioning a virtual network service. Furthermore, we propose a general data model, specifically for NFV, starting from the TM Forum SID. We believe that vConductor will be a catalyst for accelerating the industrialization of NFV.
Characterization of a TiCl4-modified silica surface by means of quantitative surface analysis (1999)

The reaction of TiCl4 with the surface of a silica gel has been investigated in detail using Fourier-transform IR photoacoustic spectroscopy (FTIR PAS) and elemental analysis. The hydroxy groups on the silica react with the TiCl4 giving rise to both monodentate and didentate surface groups. The parameters influencing the relative distribution of these groups have been studied. A quantitative description of the chemisorbed species has been obtained as a function of the pretreatment and the reaction temperatures.
Advanced model‐based control strategies for the intensification of upstream and downstream processing in mAb production (2017)

Current industrial trends encourage the development of sustainable, environmentally friendly processes with minimal energy and material consumption. In particular, the increasing market demand in biopharmaceutical industry and the tight regulations in product quality necessitate efficient operating procedures that guarantee products of high purity. In this direction, process intensification via continuous operation paves the way for the development of novel, eco-friendly processes, characterized by higher productivity and lower production costs. This work focuses on the development of advanced control strategies for (i) a cell culture system in a bioreactor and (ii) a semicontinuous purification process. More specifically, we consider a fed-batch culture of GS-NS0 cells and the semicontinuous Multicolumn Countercurrent Solvent Gradient Purification (MCSGP) for the purification process. The controllers are designed following the PAROC framework/software platform and their capabilities are assessed in silico, against the process models. It is demonstrated that the proposed controllers efficiently manage to increase the system productivity, returning strategies that can lead to continuous, stable process operation. © 2017 American Institute of Chemical Engineers Biotechnol. Prog., 33:966-988, 2017.
Panton-Valentine leukocidin-producing Staphylococcus aureus infections: Report of 4 French cases (2006)

We report 4 cases of community-acquired infections due to Staphylococcus aureus producing Panton-Valentin leukocidin (SA-PVL) with uncommon multivisceral localizations. These cases highlight the need to screen for PVL in patients with serious staphylococcal infections. All patients were cured. Two of them received intravenous immunoglobulins in addition to antibiotics.
Low-power design methodology for Gbit/s bipolar LSIs (2002)

A low-power Gbit/s operating bipolar standard cell LSI design methodology is described. It features a performance-driven layout, highly accurate static timing analysis, and CAD-based optimization for power dissipation. A 5.6-k-gate SDH signal-processing LSI operates at 1.6 Gbit/s with only 3.9 W power consumption.
Carbon Nanotubes as Intracellular Protein Transporters:  Generality and Biological Functionality (2005)

Various proteins adsorb spontaneously on the sidewalls of acid-oxidized single-walled carbon nanotubes. This simple nonspecific binding scheme can be used to afford noncovalent protein-nanotube conjugates. The proteins are found to be readily transported inside various mammalian cells with nanotubes acting as the transporter via the endocytosis pathway. Once released from the endosomes, the internalized protein-nanotube conjugates can enter into the cytoplasm of cells and perform biological functions, evidenced by apoptosis induction by transported cytochrome c. Carbon nanotubes represent a new class of molecular transporters potentially useful for future in vitro and in vivo protein delivery applications.
Hydroxylapatite ossicular replacement prostheses: Results in 157 consecutive cases (1992)

The use of hydroxylapatite for ossicular chain reconstruction is increasing. In this study, hearing results and extrusion rate for 157 consecutive patients receiving hydroxylapatite prostheses were evaluated. Results were compared to those of a control group of patients who had received either homograft bone or Plasti-Pore prostheses. Four (2.6%) cases of extrusion have occurred. Hearing success was defined as a postoperative puretone average air-bone gap of < or = 15 dB for incus prostheses and partial ossicular replacement prostheses (PORPs) or < or = 25 dB for incus-stapes prostheses and total ossicular reconstruction prostheses (TORPs). Overall success rate in the hydroxylapatite group was 51.4% for the 140 patients with postoperative data (mean follow-up, 11.5 months) and 46.7% for 90 patients who were followed for more than 6 months (mean follow-up, 16 months). PORP results were significantly poorer than those of the other prostheses. The success rate for the control group was 58.6% for 58 patients. The difference between hydroxylapatite and control group success rates appears to be due to the poorer results of the hydroxylapatite PORP.
Spectroscopically Labeled Peptaibiotics. Synthesis and Properties of Selected Trichogin GA IV Analogs Bearing a Side‐Chain‐Monofluorinated Aromatic Amino Acid for19F‐NMR Analysis (2013)

We prepared by solid-phase methods, chromatographically purified, and characterized three analogs of the ten-amino acid-residue, membrane-active, lipopeptaibiotic trichogin GA IV, each containing a single (4-fluorophenyl)alanine in position 3, 7, or 10, where it replaces the hydrophobic residue Leu(3) , Leu(7) , or Ile(10) , respectively. We incorporated the fluorine probe based on the observation that the (19) F-NMR technique has been extensively utilized to analyze peptidemembrane interactions in biological systems. A detailed conformational investigation in solution, including a membrane-mimetic environment, was performed on these compounds using FT-IR absorption, CD, and 2D-NMR, combined with molecular-dynamics calculations. The experimentally observed, mixed 310 /α-helical structures unequivocally show that the principal conformational features of trichogin GA IV are preserved in all three analogs. Analogies and differences between the behavior of the natural lipopeptaibiotic and those of the peptides characterized by the side-chain monofluorinated aromatic amino acid were found in membrane-permeabilization experiments and antimicrobial assays. The results of a preliminary solution (19) F-NMR study support the view that the (19) F label is an excellent reporter for changes in the helical environment of the peptide.
Controlling overload in networks of SIP servers (2008)

The session initiation protocol (SIP) is rapidly being adopted as the signaling protocol for establishing, modifying and terminating multimedia sessions. With the increasing use of SIP in large deployments, it is now becoming apparent that the current SIP design does not easily scale up to large network sizes and SIP servers are not well equipped to handle overload conditions. When a SIP server is operating close to or above its capacity limit, message retransmissions by various SIP timers can cause the network to be severely overloaded and result in an extremely low goodput. In this paper, we first provide a detailed analysis of the behavior of SIP servers under overload. We show that SIP servers are often unable to recover from congestion collapse once it has occurred and that overload can spread throughout a network of SIP servers. We then discuss mechanisms and algorithms for controlling overload in these servers. We found that performing overload control locally at a server provides a simple remedy for light cases of overload; however, it is ineffective in handling higher amounts of load. Finally, we investigate distributed overload control mechanisms for SIP and show that they are effective in controlling overload of SIP servers.
Effects of Targeted Grazing and Prescribed Burning on Community and Seed Dynamics of a Downy Brome (Bromus tectorum)–Dominated Landscape (2012)

Abstract Downy brome ( Bromus tectorum L.)—dominated communities can remain as stable states for long periods, even with frequent disturbance by grazing and fire. The objective of this study was to determine the effectiveness of using targeted cattle grazing and late-season prescribed burning, alone and in combination, to reduce B. tectorum seed bank input and seed bank density and thus alter aboveground community dynamics (species composition) on a B. tectorum –dominated landscape in northern Nevada. Cattle removed 80 to 90% of standing biomass in grazed plots in May of 2005 and 2006 when B. tectorum was in the boot (phenological) stage. Grazed and ungrazed plots were burned in October 2005 and 2006. The combined grazing–burning treatment was more effective than either treatment alone in reducing B. tectorum seed input and seed bank density, and in shifting species composition from a community dominated by B. tectorum to one composed of a suite of species, with B. tectorum as a component rather than a dominant. This study provides a meso-scale precursor for landscape-scale adaptive management using grazing and burning methodologies.
CMOS Compatible Growth of High Quality Ge, SiGe and SiGeSn for Photonic Device Applications (2015)

Germanium films were deposited on silicon substrate by an ultra-high vacuum chemical vapor deposition system using GeH 4 as Ge precursor and different carrier gases (Ar, N 2 and H 2 ). Silicon-germanium and SiGeSn films were deposited using optimized growth conditions of Ge growth. Silane and SnD 4 were used as precursors for Si and Sn, respectively. A complete study of SiGe growth at chamber pressure from 0.1 to 1.0 torr and at temperatures from 350-450ºC for different SiH 4 flow rate is performed. Silicon incorporation in Ge films varied from 1% to 17%. Tin incorporation of 2% was observed in the films with 17% Si incorporation. Investigation of film quality has been done using etch pit measurement, scanning electron microscopy and transmission electron microscopy. Threading dislocation density for Ge, SiGe and SiGeSn films were 1.7×10 7 cm -2 , 2.3 ×10 7 cm -2 and 4.0 ×10 7 cm -2 , respectively.
Tuning the Free Volume Cavities of Polyimide Membranes via the Construction of Pseudo-Interpenetrating Networks for Enhanced Gas Separation Performance (2009)

A novel synthetic strategy to fine-tune the cavity size and free volume distribution of polyimide membranes via the formation of homogeneous pseudo-interpenetrating polymer networks (IPN) is explored in this study. The transformation in the free volume characteristics of the pseudo-IPN can be effectively exploited for achieving enhanced gas transport properties. The construction of the pseudo-IPNs entails the in situ polymerization of azido-containing monomers with multireactive sites within rigid polyimide molecular scaffolds. The intrinsic free volume of the host polyimide and the dimensions of the azido-containing monomer predominantly influence the mean cavity size of the semi-IPN. The pseudo-IPNs assembled using fluorinated polyimides and 2,6-bis(4-azidobenzylidene)-4-methylcyclohexanone (azide) display improved CO2/CH4 and H2/N2 separation performance. The alterations in the gas permeability and gas pair permselectivity of the semi-IPNs are adequately mapped to the variation in the free volume distributions characterized by the positron annihilation lifetime spectroscopy. Depending on the functionalities of the host polyimides, chemical cross-links are formed between the azide network and the preformed linear polyimide. The chemical bridges in conjunction with the interpenetrating network restrict the mobility of the polymer chains and suppress CO2-induced plasticization.
Device and method for luminescence enhancement by resonant energy transfer from an absorptive thin film (2023)

Disclosed are a device and a method for the design and fabrication of the device for enhancing the brightness of luminescent molecules, nanostructures, and thin films. The device includes a mirror, a dielectric medium or spacer, an absorptive layer, and a luminescent layer. The absorptive layer is a continuous thin film of a strongly absorbing organic or inorganic material. The luminescent layer may be a continuous luminescent thin film or an arrangement of isolated luminescent species, e.g., organic or metal-organic dye molecules, semiconductor quantum dots, or other semiconductor nanostructures, supported on top of the absorptive layer.
Mixed-Domain Simulation of Intermodulation Distortion in RF-MEMS Capacitive Shunt Switches (2003)

A hierarchical MEMS design library, implemented in SpectreHDL® within the Cadence® simulation framework, is applied to the study of distortion phenomen in RF-MEMS capacitive shunt switches. Two-tone mixeddomain transient simulation of the non-actuated switch, operated at high-power, directly shows, for the first time, self-biasing modulation at the tones spacing frequency. Adjacent-channel intermodulation products are observed and quantified, proving that the adopted mixed-domain simulation approach is the key tool for addressing system-level specifications in RF-MEMS design for wireless applications.
Dynamics of cis/trans isomerization of the cysteine6-proline peptide bonds of oxytocin and arginine-vasopressin in aqueous and methanol solutions (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDynamics of cis/trans isomerization of the cysteine6-proline peptide bonds of oxytocin and arginine-vasopressin in aqueous and methanol solutionsCynthia K. Larive and Dallas L. RabensteinCite this: J. Am. Chem. Soc. 1993, 115, 7, 2833–2836Publication Date (Print):April 1, 1993Publication History Published online1 May 2002Published inissue 1 April 1993https://pubs.acs.org/doi/10.1021/ja00060a033https://doi.org/10.1021/ja00060a033research-articleACS PublicationsRequest reuse permissionsArticle Views258Altmetric-Citations40LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An Update on Refractory Hypertension (2022)

Refractory hypertension (RfHTN) is defined as blood pressure (BP) that is uncontrolled despite using ≥ 5 antihypertensive medications of different classes, including a long-acting thiazide diuretic and a mineralocorticoid receptor antagonist (MRA) at maximal or maximally tolerated doses. This new phenotype is different from resistant hypertension (RHTN), defined as BP that is uncontrolled despite using ≥ 3 medications, commonly a long-acting calcium channel blocker (CCB), a blocker of the renin-angiotensin system (angiotensin-converting enzyme [ACE] inhibitor or angiotensin receptor blocker [ARB]), and a diuretic. The RHTN phenotype includes controlled RHTN, BP that is controlled on 4 or more medications. RfHTN is largely attributable to increased sympathetic activity, unlike RHTN, which is mainly due to increased intravascular fluid volume frequently caused by hyperaldosteronism and chronic excessive sodium ingestion. Compared to those with controlled RHTN, patients with RfHTN have a higher prevalence of target organ damage and do not have elevated aldosterone levels. Ongoing clinical trials are assessing the safety and efficacy of using devices to aid with BP control in patients with RfHTN. RfHTN is a separate entity from RHTN and is generally attributable to increased sympathetic activity.
Proteoglycan-type I collagen fibril interactions in bone and non-calcifying connective tissues (1985)

The association of proteoglycans with type I collagen fibrils in skin, tendon, cornea and bone has been determined by electron microscopy using an electron-dense dye, Cupromeronic blue, in the critical electrolyte concentration mode, backed up by biochemical analysis and digestion by hyaluronidase or keratanase. A major proteoglycan of the soft tissues, containing dermatan sulphate, is shown to be regularly and orthogonally arranged at the surface of the fibrils. Uranyl acetate counterstaining revealed that the main specific binding site is the 'd' band, which previous work indicated is very close to the initial site of calcification of type I collagen fibrils. Bone, demineralized by a 'non-aqueous' technique which preserves the proteoglycan in the tissue, does not contain orthogonal arrays; the interfibrillar proteoglycan filaments are oriented parallel to the fibril axis. The main proteoglycan in bone is chondroitin sulphate-rich. It is suggested that dermatan sulphate proteoglycan plays a role in preventing soft connective tissues from calcifying.
ChemInform Abstract: DIE KINETIK DER GLEICHGEWICHTSEINSTELLUNG VON BISULFIT UND DEXAMETHASON‐21‐PHOSPHAT IN WAESSRIGER LOESUNG (1972)

Abstract Das Dexamethasonphosphat (I) reagiert in einer reversiblen Reaktion mit Natriumhydrogensulfit zu dem Additionsprodukt (II).
Pre‐transfusion management of children with severe malarial anaemia: a randomised controlled trial of intravascular volume expansion (2005)

Symptomatic severe malarial anaemia (SMA) has a high fatality rate of 30-40%; most deaths occur in children awaiting blood transfusion. Blood transfusion services in most of Africa are not capable of delivering adequate supplies of safe blood in a timely manner to critically ill children with SMA. Contrary to widely held belief, hypovolaemia, rather than heart failure, has emerged as a common complication in such children. We examined the safety of pre-transfusion management (PTM) by volume expansion, aimed at stabilizing children and obviating the urgency for blood transfusion. Kenyan children with severe falciparum anaemia (haemoglobin <5 g/dl) and respiratory distress were randomly assigned to 20 ml/kg of 4.5% albumin or 0.9% saline or maintenance only (control) while awaiting blood transfusion. PTM was apparently safe since it did not lead to the development of pulmonary oedema or other adverse events. There was no significant difference in the primary outcome [mean percentage reduction in base excess between admission and 8 h (95% confidence interval)] between the control group 42% (19-66%) albumin group 44% (32-57%) and saline group 36% (16-57%); adjusted analysis of variance F=0.31, P=0.7. However, the number of children requiring emergency interventions was significantly greater in the control group, four of 18 (22%) than the saline group 0 of 20 (P=0.03). We have established the safety of this PTM in children with SMA whilst awaiting blood transfusion at a hospital with an adequate blood-banking program. The impact on mortality should be assessed where blood transfusion services are unable to supply emergency transfusions.
Slow-Binding Human Serine Racemase Inhibitors from High-Throughput Screening of Combinatorial Libraries (2006)

One-bead one-compound combinatorial chemistry together with a high-throughput screen based on fluorescently labeled enzyme allowed the identification of slow binding inhibitors of human serine racemase (hSR). A peptide library of topographically segregated encoded resin beads was synthesized, and several hSR-binding compounds were isolated, identified, and resynthesized for further kinetic study. Of these, several showed inhibitory effects with moderate potency (high micromolar K(I)s) toward hSR. A clear structural motif was identified consisting of 3-phenylpropionic acid and histidine moieties. Importantly, the inhibitors identified showed no structural similarities to the natural substrate, L-serine. Detailed kinetic analyses of the properties of selected inhibitors show that the screening protocol used here selectively identifies slow binding inhibitors. They provide a pharmacophore for the future isolation of more potent ligands that may prove useful in probing and understanding the biological role of hSR.