gebhart/patrepeval huggingface dataset:
Lactic Acid Bacteria Fermentation and Endopeptidase Treatment Improve the Functional and Nutritional Features of Arthrospira platensis (2021)

This study aimed at investigating the effect of fermentation and enzymatic treatment on the degree of proteolysis of wet (WB), dried at low temperature (DB), and freeze-dried Spirulina (LB) proteins that affect the nutritional (e.g., amino acid content and profiles, and protein digestibility) and functional (e.g., antioxidant and antimicrobial activities) properties. The desiccation treatments influenced the unprocessed Spirulina characteristics because, compared with that in WB, peptides and free amino acids content was 73% lower in DB and 34% higher in LB. An integrated approach, including chromatographic and electrophoresis analyses, was used to evaluate the effect of the different bioprocessing options on protein profiles, release of peptides and amino acids, and the overall protein digestibility. Compared with the application of fermentation with the selected <i>Lactiplantibacillus plantarum</i> T0A10, the treatment with the endopeptidase Alcalase<sup>®</sup>, alone or combined, determined the most intense proteolysis. Moreover, the treatment with Alcalase<sup>®</sup> of LB allowed the release of potentially bioactive compounds that are able to inhibit <i>Penicillium roqueforti</i> growth, whereas the combination of fermentation with <i>L. plantarum</i> T0A10 and Alcalase<sup>®</sup> treatment increased Spirulina antioxidant properties, as determined by the scavenging activity toward ABTS radical (up to 60%) and antimicrobial activity against food pathogen <i>Escherichia coli</i>.
SVM-DT-based adaptive and collaborative intrusion detection (2017)

As a primary defense technique, intrusion detection becomes more and more significant since the security of the networks is one of the most critical issues in the world. We present an adaptive collaboration intrusion detection method to improve the safety of a network. A self-adaptive and collaborative intrusion detection model is built by applying the Environmentsclasses, agents, roles, groups, and objects (E-CARGO) model. The objects, roles, agents, and groups are designed by using decision trees (DTs) and support vector machines (SVMs), and adaptive scheduling mechanisms are set up. The KDD CUP 1999 data set is used to verify the effectiveness of the method. The experimental results demonstrate the feasibility and efficiency of the proposed collaborative and adaptive intrusion detection method. Also, the proposed method is shown to be more predominant than the methods that use a set of single type support vector machine (SVM) in terms of detection precision rate and recall rate.
Beta 3 adrenoceptor: a potential therapeutic target for pulmonary arterial hypertension (2020)

<b>Rationale:</b> Beta 3 adrenoceptors (β3ARs), expressed in cardiac and pulmonary vascular tissue, and upregulated in cardiac diseases are cardioprotective. By attenuating myocardial remodelling and their vasodilatory effects, β3ARs are a promising target in pulmonary arterial hypertension (PAH) as current available therapies exclusively act as pulmonary vasodilators and cannot cure the disease. <b>Methods:</b> We evaluated the protective role of β3AR in vivo in the rat model of monocrotaline (MCT)-induced PH and ex-vivo by investigating the vasoreactivity of rat isolated pulmonary vessels. <b>Results:</b> Chronic effects of different doses of the β3AR agonist mirabegron were tested using telemetry and we did not observe any effect on right ventricular or systemic pressures in control rats. A curative treatment using a low dose of mirabegron (30 mg/kg, per os, daily for 1 to 2 weeks) failed to revert MCT-induced PAH in rats. We next designed an in-vivo dose-response (50-200 mg/kg) preventive protocol in MCT-rats and observed that 200 mg/kg mirabegron resulted in a significant decrease in systolic and mean pulmonary arterial pressure; sysPAP 62±15 vs 46±12, p=0.02 and mPAP 35±8 vs 27±9, p=0.04) without any effect on mortality. Ex-vivo, pulmonary arteries isolated both from control and MCT-induced PH rat, and pre-constricted with 30 µM serotonin showed an endothelial-dependent relaxation (p&lt;0.0001) amounting to respectively 54±18 and 49±12% of the maximum contraction in response to 100 µM mirabegron. <b>Conclusion:</b> Mirabegron prevented experimental PH in vivo and induced endothelial-dependent relaxation of isolated rat pulmonary arteries, suggesting that β3AR agonists could be safely and efficiently repurposed for PAH.
Total body photography for skin cancer screening (2014)

Rapid-acquisition automated skin photography is feasible with a low-cost system, with excellent lesion visualization and participant acceptance. These data provide a basis for employing this method in clinical melanoma screening.
Fast and High-Accuracy Approximate MAC Unit Design for CNN Computing (2021)

Multiply and accumulate (MAC) composed of a set of multipliers and one reduction dominates the latency and power of convolutional neural network (CNN) accelerators. Existing approximate multipliers reduce latency and power at a tolerable drop in accuracy, without considering the data distribution (implicitly assuming that data are uniformly distributed). This letter discloses that practical CNNs’ activations and weights are usually Gaussian-like distributed, and the bits of quantized activations and weights are typically not with a probability of 0.5. Thus, we propose an approximate MAC unit design by taking into account the statistical features of input data, to achieve a balanced tradeoff among latency, power, and accuracy. The extensive experiments show that our proposed MAC unit design provides much higher accuracy than state-of-the-art approximate circuits, while the latency, area, and power are similar.
ChemInform Abstract: HORMONE‐RECEPTOR INTERACTIONS, DEMONSTRATION OF TWO MESSAGE SEQUENCES (ACTIVE SITES) IN ALPHA‐MELANOTROPIN (1975)

Abstract Die biologische Bedeutung der Tripeptid‐Sequenz 1 1‐l 3 (‐Lys‐Pro‐Val‐NH2), die im α‐Melanocyten‐stimulierenden Hormon enthalten ist, wird aufgeklärt.
Rotational atherectomy in coronary dissection. (2010)

Rotational atherectomy is contraindicated in the presence of coronary dissection. Clinical scenarios of coronary dissection in which rotational atherectomy offers the only option are rare but can occur. This case study presents a challenging circumstance of an extensive coronary dissection resulting from failed angioplasty of a resistant and undilatable lesion. Rotational atherectomy was used as a last resort when the patient became clinically unstable. Standard technique of rotational atherectomy and additional technical considerations for this uncommon but potentially devastating scenario are discussed.
Geotechnical Characterization and Sedimentation Behavior of Laterite Slurries (2005)

Abstract Laterites are the main source of economic metals such as nickel and cobalt. In many parts of the globe, these metals are extracted using the pressure acid leach operation. An efficient rate of sedimentation and a high solids content of the material are two prerequisites for this process. To understand the geotechnical behavior of laterite slurries under ambient process conditions, a comprehensive laboratory characterization and sedmentation protocol was developed. Results indicate that due to changes in material characteristics, sedimentation behavior of laterite slurries is improved during the metal extraction process. The rate and concentration of sedimentation are directly related for this class of materials.
A comparative study on distillation methods for oil content, chemical composition, yield and economics in Eupatorium adenophorum (2020)

An experiment was conducted to assess oil content (%), chemical composition, oil yield and economics in An experiment was conducted to assess oil content (%), oil yield (kg/10q) and economic returns (Rs/10 q) in Eupatorium adenophorum via two different distillation methods: Hydro-steam and Steam distillation. Maximum oil content (0.23%) was achieved by Hydro-steam distillation method as compared to Steam distillation (0.18%). Further, Hydro-steam distillation (2.27 kg/10q) exceeded Steam distillation (1.82 kg/10q) in term of oil yield. The economic returns were also significantly higher for Hydro-steam distillations (Rs 10696.60/ 10 q) as compared to steam distillation (Rs.7376.40/10 q). Experimental finding reveals Hydro-steam distillation to be significantly better than Steam distillation in terms of oil content (%), oil yield (kg/10 q) and economic returns (Rs/ 10q). The suitability and feasibility of Hydro-steam distillation were found to be more appropriate under field/ farm conditions in comparison to Steam distillation. Further, the chemical compositions of essential oil via two different methods were largely similar. GC-MS analysis of the essential oil showed that the presence of p-cymene (12.87%), α-Phellandrene (9.35%), Cis-Cadin-4-en-7-ol (7.46%), Bornyl acetate (5.97%), Camphene (5.75%), g-patchoulene (5.18%), δ-2-carene (4.26%) as major constituents in steam distillation and p-cymene (11.31%), α -Phellandrene (7.92%), Cis-Cadin-4-en-7-ol (8.52%), Bornyl acetate (5.78%), Camphene (5.08%), g-patchoulene (4.40%), δ-2-carene (4.00%) in Hydro-steam distillation respectively.
Selective Gene Expression of Latent Murine Gammaherpesvirus 68 in B Lymphocytes (2003)

Intranasal infection of mice with murine gammaherpesvirus 68 (MHV-68), a virus genetically related to the human pathogen Kaposi's sarcoma-associated herpesvirus, results in a persistent, latent infection in the spleen and other lymphoid organs. Here, we have determined the frequency of virus infection in splenic dendritic cells, macrophages, and several B-cell subpopulations, and we quantified cell type-dependent virus transcription patterns. The frequencies of virus genome positive cells were maximal at 14 days postinfection in all splenic cell populations analyzed. Marginal zone and germinal center B cells harbored the highest frequency of infection and the former population accounted for approximately half the total number of infected B cells. Analysis of virus transcription during the establishment of latency revealed that virus gene expression in B cells was restricted and dependent on the differentiation stage of the B cell. Notably, transcription of ORF73 was detected in germinal center B cells, a finding in agreement with the predicted latent genome maintenance function of ORF73 in dividing cells. At late times after infection, virus DNA could only be detected in newly formed and germinal center B cells, which suggests that B cells play a critical role in facilitating life-long latency.
A mobile-display-driver IC embedding a capacitive-touch-screen controller system (2010)

We present a display-driver IC embedding a capacitive-touch-screen controller. It is designed to operate with conventional overlay-type and on-cell touch display panels. The IC exhibits performance of 40 ms latency and 120 Hz update rate within ±0.5 mm jitter. It has been evaluated on a 16.7 M-color wQVGA AMOLED panel with on-cell touch screen.
Kinetic evaluation of the propranolol-quinidine combination (1980)

The kinetics of quinidine and propranolol, administered singly and in combination, were evaluated in 5 healthy subjects. The orally administered doses resulted in plasma concentrations within the therapeutic range. For each drug the average steady-state plasma concentration, maximal plasma concentration, and time of maximum plasma concentration were not altered by the presence of the other drugs. This study shows no kinetic interaction between quinidine and propranolol in normal subjects.
Effects of Growth Hormone on Pancreatic Cancer Derived Exosomes (2021)

Abstract In 2020, the National Cancer Institute (NCI) estimates 57,600 new cases and 47,050 deaths in the US due to pancreatic ductal adenocarcinoma (PDAC). A dismal 10% five-year overall survival rate in PDAC is attributed to late diagnosis, limited treatment options, a remarkably high metastasis rate, and resistance of this cancer to available therapies. Therefore, a better understanding of the mechanisms of how PDAC tumors acquire drug resistance and spread to distal parts of the body are necessary for developing novel therapeutic approaches. Exosomes, microscopic vesicles released from most cells (both tumor and non-tumor) have been recently established to play a significant role in cell to cell communication. Exosomes modulate their target cell responses systematically depending on the nature of exosomal cargoes (nucleic acids, proteins, and lipids). PDAC derived exosomes have been implicated to promote metastasis via forming a pre-metastatic niche of cells as well as enhancing drug resistance. Growth hormone (GH) secreted primarily by the pituitary gland promotes metastasis and drug resistance as shown by plethora of studies. No study has directly assessed the effect of GH on exosomal cargoes in terms of promoting metastases and drug resistance. In this report, we show that GH modulates various pancreatic cancer cell exosomal cargoes which in turn potentially amplifies tumor invasion and metastases. Our data shows that GH treatment on human and mouse PDAC cells increases the exosomal protein levels of TGFβ - a critical inducer of epithelial-to-mesenchymal transition (EMT, a process leading to metastasis). In addition, GH treatment also increases extracellular matrix-degrading enzymes, MMP2 and 9, as well as multi-drug efflux pump ABCC1, ABCB1, and ABCG2 in PDAC cells. These results strongly implicate GH action in driving EMT and chemoresistance via exosomes in pancreatic cancer. Exosomes have a crucial impact especially in the areas of diagnostics and therapeutics. This report is the first to show that GH modulates the effects of exosomes secreted by pancreatic cancer cells. Acknowledgement: This work was supported in part by the State of Ohio’s Eminent Scholar Program that includes a gift from Milton and Lawrence Goll, by the AMVETS, and Ohio University’s Student Enhancement Award and Edison Biotechnology Institute.
Cross-shaped bandpass filters for the near- and mid-infrared wavelength regions (1996)

A photolithographic process has been used to form cross-shaped patterns in 3-μm-thick nickel foils. Patterns with cross arm dimensions in the 10-20-μm range, and with periodicities in the 16-26-μm range, yield self-resonant bandpass filters for wavelengths in the 20-25-μm region. Transmittances as high as 80% were achieved with center wavelength-to-bandwidth ratios (λ(R)/Δλ) of ~5. We present a simple empirical formula that relates the wavelength of peak transmittance, or resonant frequency, with cross dimensions and periodicity.
High Accuracy Capacitance Type Fuel Sensing System (1993)

&lt;div class="htmlview paragraph"&gt;A highly accurate fuel sensing system has been developed which provides a digital indication of the remaining fuel on a l/P cluster.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;This system uses capacitance type sensors placed in the fuel tank to detect fuel level changes.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;This system uses three capacitance type sensors which enables it to determine highly accurate fuel level even in sloped surfaces.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;This fuel level sensor has been in production since 1991 and today is used on the TOYOTA SOARER in Japan.&lt;/div&gt;
Morphologic classification of microvessels in hepatocellular carcinoma is associated with the prognosis after resection (2010)

The results of our study suggested that the microvessel type is an effective predictor of survival in patients with HCC after resection, which might serve as potential novel therapeutic targets for prevention of the recurrence of HCC after resection.
New Methods for the Synthesis of 2-Arylpyrroles (1987)

Tvo short and efficient synthetic approaches for -mostly unknown-2-arylpyrroles are presented.The key intermediates 2 are conveniently obtained from cammercially available acetophenones 2 (method I) or benzoic acid derivatives 10, (method 11). 1 In connection with a synthetic program directed at psychoactive compounds ve needed a short, efficient synthesis for 2-phenylpyrroles 1, applicable for large scale preparations.Also a vide variety of substituents R and replacement of 2-phenyl by heteroaryl groups should be allowed.Only a few 2-phenylpyrrole syntheses.described in literature give rise to 3,4.5unsubstituted derivatives.nethods based on formation of the C2-N bond by cyclization reactions were described by everi in'^.^, using 1-phenylbut-2-en-Lone derivatives &, g , 3 and &.Similarly, chlorobutenanes g were described as precursors by Rosenmund .Other strategies are also based on intramolecular condensation reactions forming either the CZ-C3 4 bond (ringclosure of N-allylbenzamides) or the C3-C4 bond (treatment of acetophenone m i m e vinyl ethers vith strong base)5.Vittig6= and ~a e k i ~~ employed intermolecular C2-phenyl band connections using benzyne and phenyldiazonium salts, respectively.None of these methods met our criteria because of at least one of the following disadvantages: lack of general applicability, poor yields or drastic reaction conditions.
Outcomes after Internal versus External Tocodynamometry for Monitoring Labor (2010)

Internal tocodynamometry during induced or augmented labor, as compared with external monitoring, did not significantly reduce the rate of operative deliveries or of adverse neonatal outcomes. (Current Controlled Trials number, ISRCTN13667534; Netherlands Trial number, NTR285.)
Data from TGFβ Programs Central Memory Differentiation in <i>Ex Vivo</i>–Stimulated Human T Cells (2023)

&lt;div&gt;Abstract&lt;p&gt;The adoptive transfer of &lt;i&gt;ex vivo&lt;/i&gt;–expanded T cells is a promising approach to treat several malignancies. Several lines of evidence support that the infusion of T cells with early memory features, capable of expanding and persisting after transfer, are associated with better outcomes. We report herein that exposure to exogenous TGFβ during human T-cell stimulation &lt;i&gt;ex vivo&lt;/i&gt; leads to the accumulation of early/central memory (Tcm) cells. Exposure to TGFβ suppressed the expression of BLIMP-1, a key orchestrator of effector T-cell differentiation, and led to the upregulation of the memory-associated transcription factor ID3. Accordingly, this was associated with an early memory transcriptional signature in both CD4&lt;sup&gt;+&lt;/sup&gt; and CD8&lt;sup&gt;+&lt;/sup&gt; T-cell subsets. The T cells stimulated in the presence of TGFβ expanded normally, and displayed polyfunctional features and no suppressive activity. The adoptive transfer of &lt;i&gt;ex vivo&lt;/i&gt;–stimulated T cells into immunodeficient mice confirmed that TGFβ-conditioned cells had an enhanced capacity to persist and mediate xenogeneic graft-versus-host disease, as predicted by their early T-cell memory phenotype. Chimeric antigen receptor–expressing T cells generated in the presence of exogenous TGFβ were cytotoxic and more effective at controlling tumor growth in immunodeficient animals. This work unveils a new role for TGFβ in memory T-cell differentiation and indicates that TGFβ signaling may be harnessed to program Tcm differentiation in the context of &lt;i&gt;ex vivo&lt;/i&gt; T-cell stimulation for adoptive immunotherapy in humans.&lt;/p&gt;&lt;/div&gt;
DEVELOPMENT OF A BRAKE-OPERATED PRE-CRASH SEATBELT SYSTEM AND PERFORMANCE EVALUATION. IN: AIR BAGS AND BELT RESTRAINTS (2004)

This study's aim was to evaluate the effectiveness of a brake operated pre-crash seatbelt system by considering the dynamic behavior of the vehicle combined with the safety performance of the vehicle during the crash. The experimental results were used in numerical simulations as the initial conditions for calculating parameters related to vehicle safety during a crash event. The results indicated that the brake operated pre-crash seatbelt system has the potential to reduce injury parameters even if emergency braking is applied prior to a crash.
A Comparative Study of the Electrochemical Characteristics of [Emim+][BF4−] and [Bmim+][BF4−] Ionic Liquids at the Surfaces of Carbon Nanotube and Glassy Carbon Electrodes (2011)

The electrochemical interfaces of a glassy carbon (GC) electrode and a carbon nanotube (CNT) paper electrode have been studied in 1-ethyl-3-methylimidazolium tetrafluoroborate (EmimBF4) and 1-butyl-3-methylimidazolium tetrafluoroborate (BmimBF4) ionic liquids (ILs) using direct current (DC) cyclic voltammetry (CV) and alternating current (AC) electrochemical impedance spectroscopy (EIS). These four electrode/electrolyte combinations serve as representative models of the relatively unconventional, spatially inhomogeneous IL−carbon interfaces that are potentially useful for electrochemical energy-storage/conversion devices. The present work explores in detail the double-layer capacitances as well as other essential electrochemical features of these interfaces. The voltage-dependent double-layer capacitances, and the interfacial charge transfer resistances have been determined within the nonfaradaic windows of these systems, independently, by using CV and EIS. The results of the DC and AC measurements have been compared to demonstrate how the material properties of such complex systems can affect their characterization procedures if they are simply treated as classical ideally polarized interfaces.
Asymptotic–numerical methods and Pade approximants for non‐linear elastic structures (1994)

Abstract In this paper, we apply asymptotic–numerical methods for computing non‐linear equilibrium paths of elastic beam, plate and shell structures. The non‐linear branches are sought in the form of asymptotic expansions, and they are determined by solving numerically (FEM) several linear problems with a single stiffness matrix. A large number of terms of the series can be easily computed by using recurrence formulas. In comparison with a more classical step‐by‐step procedure, the method is rapid and automatic. We show, with some examples, that the choice of the expansion's parameter and the use of Padé approximants play an important role in the determination of the size of the domain of convergence.
Capacity changes in German certified chest pain units during COVID-19 outbreak response (2020)

Certified German CPUs are able to maintain adequate coverage for chest pain patients in COVID-19 pandemic despite structural changes. However, at this time, it appears important to add operating procedures during pandemic outbreaks to the certification criteria of forthcoming guidelines either at the individual CPU level or more centrally steered by the German Cardiac Society or the European Society of Cardiology.
On the Impact of Numerology in NR V2X Mode 2 with Sensing and Random Resource Selection (2021)

In this paper, we use a New Radio (NR) Vehicular-to-everything (V2X) standard compliant simulator based on ns-3, to study the impact of NR numerologies on the end-to-end performance. In particular, we focus on NR V2X Mode 2, used for autonomous resource selection in out-of-coverage communications, and consider the two key procedures defined in 3GPP: sensing based and random resource selection. We pay particular attention to the interplay between the operational numerology and the resource selection window length, a key parameter of NR V2XMode 2. The results in a standard-compliant and end-to-end simulation platform show that in all the cases, for basic service messages, a higher numerology is beneficial because of different reasons, depending on the way the resource selection window length is established.
High Hardness and Ductile Mosaic SiC / SiO 2 Composite by Spark Plasma Sintering (2014)

SiC powder was coated with SiO 2 layer by chemical vapor deposition, and the SiC (core)/ SiO 2 (shell) composite powder was consolidated to a SiC / SiO 2 composite with a mosaic microstructure by spark plasma sintering ( SPS ) at 1923 K for 1.8 ks. The SiC (core)/ SiO 2 (shell) powder with a 80–100 nm thick SiO 2 layer resulted in a SiC / SiO 2 composite with a relative density of 97% and hardness and fracture toughness of 17.1 GPa and 8.4 MPa m 1/2 , respectively.