gebhart/patrepeval huggingface dataset:
Postextrasystolic regulation patterns of blood pressure and heart rate in patients with idiopathic dilated cardiomyopathy (2002)

Assessment of fluctuations in heart rate (HR) following a premature ventricular complex (PVC) is valuable for identifying patients at high risk of sudden cardiac death. We hypothesised that postextrasystolic potentiation is the main determinant of the regulation patterns of blood pressure (BP) and HR following a PVC. Twelve patients with idiopathic dilated cardiomyopathy (IDC) and 13 control subjects with single PVCs (comparable coupling intervals) were investigated. Non-invasive finger arterial BP and ECGs were analysed. Regulation patterns following a single PVC were quantified using the indices postextrasystolic amplitude potentiation (PEAP) and maximum turbulence slope of five consecutive mean BP values (MBP-TS), and compared with the HR turbulence parameters turbulence slope (HR-TS) and turbulence onset (HR-TO). PEAP was significantly higher in IDC patients compared to controls (48.7 +/- 32.6 vs. 9.8 +/- 5.4 %, P < 0.01), whereas MBP-TS was lower (0.97 +/- 0.60 vs. 2.07 +/- 1.04 mmHg BBI(-1) (BBI, beat-to-beat interval), P < 0.05), as was HR-TS (8.46 +/- 7.90 vs. 30.73 +/- 22.90 ms BBI(-1), P < 0.01). HR-TO was significantly higher in IDC patients (-0.56 +/- 2.19 vs. -5.52 +/- 4.13 %, P < 0.01). In addition, the regulation patterns of BP and HR following a single PVC differed significantly between IDC patients and controls. Specifically, we observed pronounced PEAPs in IDC patients. The baroreflex response initiated by the low pressure amplitude of the PVC was suppressed in IDC patients due to the augmented potentiation of the first postextrasystolic blood pressure. Furthermore, IDC patients displayed impressive postextrasystolic pulsus alternans phenomena, whereas healthy subjects exhibited a typical baroreflex pattern. The pulsus alternans phenomenon seems to be triggered by a PVC.
Chimeric Antigen Receptor T Cells Targeting CD79b Show Efficacy in Lymphoma with or without Cotargeting CD19 (2019)

Our findings demonstrate that CAR T cells targeting CD79b alone or in combination have promise for treating and preventing CD19 antigen escape in B-cell lymphomas.
Estimation of Frequency Dispersive Complex Permittivity Seen by Each Antenna for Enhanced Multistatic Radar Medical Imaging (2017)

Radar-based microwave imaging requires the effective dielectric properties of the imaged object as a priori information. A technique to determine the effective complex permittivity seen by each imaging antenna across the used frequency band of a multistatic imaging domain is presented. The method uses spatial statistical techniques to model the complex permittivity of the imaging domain as a function of scattering parameters. The proposed method does not require any predefined gap between the antennas and the imaged object, nor does it need the imaged object to be centered within the imaging domain. Also, the method does not need to know boundaries of the imaged object. The proposed method is tested via simulations and experiments using a multistatic human torso imaging system. The collected data across the band 0.65-1.75 GHz using twelve antennas around the human torso are processed to generate accurate images. The results demonstrate significant improvements in image quality and detection accuracy compared to conventional average-permittivity methods. The efficacy of the proposed method is verified experimentally in detecting an early case of lung cancer in a human torso phantom.
Volume Reduction of Radiocesium-Contaminated Soil by Air-Lift Washing Process: (2014)

放射性セシウム汚染土壌の減容化を目的とし，空気揚土撹拌式洗浄装置（100 L），凝集沈殿槽，脱水機で構成する小型システムを構築した．福島県飯舘村の駐車場の汚染土壌（137Cs 6.2×103～1.5×104 Bq/㎏）を 洗浄したところ，75～86％の137Csを14～17％の重量の土壌粒子（3.0×104～7.4×104 Bq/㎏）として理想的に回収できた．笹薮の土壌（1.9×104 Bq/㎏）からは87～89％の137Csを回収できたが（3.0×104～7.4×104 Bq/㎏），その重量は元の53～55％もあった．川内村の農道と側溝の土壌（1.0×103～7.3×103 Bq/㎏）を処理したところ，脱水ケーキ（4.4×103～3.1×104 Bq/㎏）として重量を10～14％にできたものの，137Csは43～46％しか回収できなかった．このように放射性セシウム汚染土壌の減容化効率は土壌特性に大きく依存した．
EXPERIMENTS ON THE JUVENILE‐ADULT PHASE CHANGE IN SOME WOODY SPECIES (1969)

S ummary The transition from the juvenile to the adult condition (‘phase change’) in woody plants normally occurs at an age and a size characteristic for the species and flowering does not occur until this change has taken place. By experiments with seedlings of birch ( Betula verrucosa ) grown either continuously under long days in a glasshouse, or periodically under alternating periods of long and short days in association with chilling treatments, it was shown that flowering occurs much sooner in the seedlings grown continuously (i.e. without periods of dormancy) than in seedlings of this species grown under normal outdoor conditions, or in the experimental seedlings grown ‘periodically’. Similar results were obtained with Japanese larch ( Larix leptolepis ) and black currant ( Ribes nigrum ) when flower‐inducing treatments appropriate for the species, viz. horizontal training or short days, respectively, were applied after continuously grown seedlings had attained a certain size. Further experiments were carried out with black currant to determine whether the attainment of a certain minimum size is necessary for phase change. The shoot tips of seedlings were removed when they had attained a size at which flowering does not occur and were rooted as cuttings; the latter plants were similarly treated and this process was repeated again twice. The final series of plants which had been derived in this manner initiated flowers in response to short days and thus had attained the adult condition, although at no stage had any of the successive rooted cuttings attained the minimum size at which phase change normally occurs in this species. It is concluded that size, per se , is not the primary factor determining the stage at which phase change occurs. Experiments were carried out with Japanese larch and European larch ( Larix decidua ) in which scions from juvenile (non‐coning) seedling trees were grafted on to mature trees which produced abundant cones but little evidence was obtained that phase change was hastened by this treatment. On the other hand, a considerable proportion of scions from young trees, which were approaching the adult condition, initiated cones following grafting on to adult trees. Phase change takes place in the shoot apical meristems, which appear to behave as autonomous units in the sense that their transition to the adult condition is apparently not determined by the amount of already differentiated tissue. It is suggested that phase change occurs after the meristems have undergone a certain number of cell divisions, so that the change is correlated with, but not determined by, the attainment of a certain size.
Quality assessment: Instrumenting the independent process variables during teaching and learning (2002)

This report is based heavily on the 1993 Strategic Plan and assessment implementation guidelines of the Synthesis Coalition. Every funded project leader in the Coalition was invited to submit a brief statement-of-work indicating the assessment method of choice and the manner in which the method will be applied: e.g., the curriculum, the students to be observed, when and where in the evolution of a student's curriculum experience they will be observed; what are the expected outcomes of the assessment; how will outcomes be fed back into the curriculum; why is that specific methodology right for this project, etc. Supplemental assessment awards will be made on a merit basis. Merit is determined by a peer review process, akin to that used for external project implementation proposal review.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Faculty Opinions recommendation of Crystal structure of a zinc-finger-RNA complex reveals two modes of molecular recognition. (2003)

Zinc-finger proteins of the classical Cys2His2 type are the most frequently used class of transcription factor and account for about 3% of genes in the human genome. The zinc-finger motif was discovered during biochemical studies on the transcription factor TFIIIA, which regulates the 5S ribosomal RNA genes of Xenopus laevis. Zinc-fingers mostly interact with DNA, but TFIIIA binds not only specifically to the promoter DNA, but also to 5S RNA itself. Increasing evidence indicates that zinc-fingers are more widely used to recognize RNA. There have been numerous structural studies on DNA binding, but none on RNA binding by zinc-finger proteins. Here we report the crystal structure of a three-finger complex with 61 bases of RNA, derived from the central regions of the complete nine-finger TFIIIA-5S RNA complex. The structure reveals two modes of zinc-finger binding, both of which differ from that in common use for DNA: first, the zinc-fingers interact with the backbone of a double helix; and second, the zinc-fingers specifically recognize individual bases positioned for access in otherwise intricately folded 'loop' regions of the RNA. PMID: 14603324
Figure S12 from Dissecting the origin of heterogeneity in uterine and ovarian carcinosarcomas (2023)

&lt;p&gt;Complete clonal evolution of P02 tumor.&lt;/p&gt;
Tracking of the Nuclear Wavepacket Motion in Cyanine Photoisomerization by Ultrafast Pump–Dump–Probe Spectroscopy (2011)

Understanding ultrafast reactions, which proceed on a time scale of nuclear motions, requires a quantitative characterization of the structural dynamics. To track such structural changes with time, we studied a nuclear wavepacket motion in photoisomerization of a prototype cyanine dye, 1,1'-diethyl-4,4'-cyanine, by ultrafast pump-dump-probe measurements in solution. The temporal evolution of wavepacket motion was examined by monitoring the efficiency of stimulated emission dumping, which was obtained from the recovery of a ground-state bleaching signal. The dump efficiency versus pump-dump delay exhibited a finite rise time, and it became longer (97 fs → 330 fs → 390 fs) as the dump pulse was tuned to longer wavelengths (690 nm → 950 nm → 1200 nm). This result demonstrates a continuous migration of the leading edge of the wavepacket on the excited-state potential from the Franck-Condon region toward the potential minimum. A slowly decaying feature of the dump efficiency indicated a considerable broadening of the wavepacket over a wide range of the potential, which results in the spread of a population distribution on the flat S(1) potential energy surface. The rapid migration as well as broadening of the wavepacket manifests a continuous nature of the structural dynamics and provides an intuitive visualization of this ultrafast reaction. We also discussed experimental strategies to evaluate reliable dump efficiencies separately from other ultrafast processes and showed a high capability and possibility of the pump-dump-probe method for spectroscopic investigation of unexplored potential regions such as conical intersections.
Embedded block coding in JPEG2000 (2000)

This paper describes the embedded block coding algorithm at the heart of the JPEG2000 image compression standard. The algorithm achieves excellent compression performance, usually somewhat higher than that of SPIHT with arithmetic coding, but in some cases substantially higher. The algorithm utilizes the same low complexity binary arithmetic coding engine as JBIG2. Together with careful design of the bit-plane coding primitives, this enables comparable execution speed to that observed with the simpler variant of SPIHT without arithmetic coding. The coder offers additional advantages including memory locality, spatial random access and ease of geometric manipulation.
Manufacturing-Aware Physical Design (2003)

Ultra-deep submicron manufacturability impacts physical design (PD) through complex layout rules and large guard-bands for process variability; this creates new requirements for new manufacturing-aware PD technologies. The first part of this tutorial reviews PD complications and methodology changes notably in the detailed routing arena - that arise from subwavelength lithography and deep-submicron manufacturing (antennas, metal planarization and mask-wafer mismatch). Process variations and their sources are taxonomized for modeling and simulation. A framework of design for cost and value is described. The second part covers yield-constrained optimizations in PD, especially corners approaches that escape today's pessimistic or even incorrect corner-based approaches. Statistical timing and noise analyses enable optimization of parametric yield and reliability. Yield-aware cell libraries and analog design rules (as opposed to digital, 0/1 rules) can help designers explore yield-cost tradeoffs, especially for low-volume parts. We then examine performance impact-limited fill insertion which goes beyond mere capacitance rules. Modeling, objectives, and filling strategies are discussed. Finally, we discuss current and near-term prospects for the overall design-to-manufacturing PD methodology. Key aspects include better integrations with analysis and manufacturing interfaces, as well as cost-benefit tradeoffs for regular layout structures that are likely beyond 90 nm, cost optimizations for low-volume production, and the role of robust and/or stochastic optimization in PD.
Phase I Study of Weekly Mitoxantrone and Docetaxel before Prostatectomy in Patients with High-Risk Localized Prostate Cancer (2004)

In this patient population, the planned Phase II regimen is 4 mg/m(2) mitoxantrone and 35 mg/m(2) docetaxel weekly for 3 of every 4 weeks. Delivery of this regimen before prostatectomy is feasible with acceptable toxicity. Additional studies are needed to determine whether this combined modality approach will reduce cancer recurrence rates in this high-risk population. Because extent of disease and exposure to prior therapy may impact treatment tolerance these safety data may not be applicable to patients with advanced prostate cancer.
Solvothermal Synthesis of Metastable γ‐MnS Hollow Spheres and Control of Their Phase (2005)

Abstract A solvothermal route has been developed to prepare metastable wurtzite‐structure γ‐MnS hollow spheres from anhydrous manganese chloride, sulfur powder, and potassium borohydride in ethylene glycol at 150–180 °C. The metastable γ‐MnS and stable α‐MnS were characterized by X‐ray diffraction, X‐ray photoelectron spectroscopy, field‐emission scanning electronic microscopy, scanning electron microscopy, transmission electron microscopy, and photoluminescence. Experiments show that the reaction temperature, the solvent, and the concentration and reducibility of the reductant are the crucial factors affecting the phase of the product. A possible growth mechanism for the hollow sphere is proposed. (© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2005)
Translation of Human β-Actin mRNA is Regulated by mTOR Pathway (2019)

The mammalian target of rapamycin (mTOR) kinase is a well-known master regulator of growth-dependent gene expression in higher eukaryotes. Translation regulation is an important function of the mTORC1 pathway that controls the synthesis of many ribosomal proteins and translation factors. Housekeeping genes such as <i>β-actin</i> (<i>ACTB</i>) are widely used as negative control genes in studies of growth-dependent translation. Here we demonstrate that translation of both endogenous and reporter <i>ACTB</i> mRNA is inhibited in the presence of mTOR kinase inhibitor (Torin1) and under amino acid starvation. Notably, 5'UTR and promoter of <i>ACTB</i> are sufficient for the mTOR-dependent translational response, and the degree of mTOR-sensitivity of <i>ACTB</i> mRNA translation is cell type-dependent.
Outgassing behavior on aluminum surfaces: Water in vacuum systems (1994)

Several different effects of water in vacuum systems were studied. An outgassing rate measurement system was used to measure outgassing rates for different venting conditions. Both diffusion and desorption phenomena were observed. The drier the venting gas, the more significant the diffusion behavior. From the pressure buildup tests, it was shown that the increasing H2O partial pressure is much less than that of the other gases. More effective surface pumping for water vapor than for the other gases is thought to be the reason. For the outgassing behaviors mentioned, an effort was made to describe the phenomenon quantitatively by using simple models. In addition to the behavior in the static vacuum, water vapor also shows an interesting behavior in the dynamic vacuum. A few results will be discussed.
Ultrasensitive Time-Resolved Fluorescence Method for α-Fetoprotein (1990)

We have examined the maximum sensitivity of a newly developed and optimized time-resolved fluorescence immunoassay system. The system, originally described elsewhere (Clin Biochem 1988:21:139-50), has undergone significant improvements in sensitivity through improvements of the labeled reagent used. We have chosen an alpha-fetoprotein (AFP) assay as a model and used monoclonal "capture" antibodies and monoclonal or polyclonal biotinylated antibodies in "sandwich-type" assay configurations. Streptavidin labeled with the europium chelator 4.7-bis(chlorosulfophenyl)-1,10-phenanthroline-2.9-dicarboxylic acid was used for detection. We can measure as few as 3 x 10(5) molecules of AFP with the optimized system. We have applied this assay to measure AFP in the serum of normal individuals after a 10-fold sample dilution. We conclude that this system is extremely sensitive and can be used in immunoassay or other applications where biotinylated reagents can be applied.
Argonne Mockup of the Two Frontend Processes for the Hot-Cell Demonstrations to be Run at Oak Ridge National Laboratory (2013)

The Global Threat Reduction Initiative (GTRI) Conversion Program develops technology necessary to convert civilian facilities that use high enriched uranium (HEU) to low enriched uranium (LEU) fuels and targets. The conversion of conventional HEU dispersion targets to LEU for the production of Mo-99 requires approximately five times the uranium in a target to maintain the Mo-99 yield per target; therefore, processes involving high-density metal LEU foil targets are a primary focus of this research and development effort.
Distributed smart space orchestration (2016)

Many networked devices that can interface their physical environments are available off-the-shelf or can be built in 2016. A comprehensive management of those Smart Devices is required to unlock the existing potential. However, the amount and heterogeneity of the devices make their management difficult. A suitable abstraction is missing. This paper identifies requirements on managing Smart Devices from diverse research fields, assesses relevant existing work, proposes a new management middleware design, and evaluates it quantitatively and qualitatively. The presented novel middleware architecture could become an enabler for a software maker culture.
On the Variance of the Adaptive Learning Rate and Beyond (2019)

The learning rate warmup heuristic achieves remarkable success in stabilizing training, accelerating convergence and improving generalization for adaptive stochastic optimization algorithms like RMSprop and Adam. Here, we study its mechanism in details. Pursuing the theory behind warmup, we identify a problem of the adaptive learning rate (i.e., it has problematically large variance in the early stage), suggest warmup works as a variance reduction technique, and provide both empirical and theoretical evidence to verify our hypothesis. We further propose RAdam, a new variant of Adam, by introducing a term to rectify the variance of the adaptive learning rate. Extensive experimental results on image classification, language modeling, and neural machine translation verify our intuition and demonstrate the effectiveness and robustness of our proposed method. All implementations are available at: https://github.com/LiyuanLucasLiu/RAdam.
Greenstick Fractures of the Middle Third of the Forearm. A Prospective Multi-Centre Study (2010)

Completion of a greenstick fracture does not prevent refracture. Nevertheless, it diminishes the extent of secondary deformities in cases where the primary angulation exceeds the remodelling capacity. Prevention of refracture should include a routine radiographic follow-up 4-6 weeks after injury with continuation of plaster fixation in cases of partial consolidation.
Adult and paediatric haematology and clinical chemistry laboratory reference limits for Liberia (2020)

Background As more research is conducted in Liberia, there is a need for laboratory reference limits for common chemistry and haematology values based on a healthy population. Reference limits from the United States may not be applicable. Objective The aim of this study was to present laboratory reference ranges from a Liberian population and compare them to United States ranges. Methods Serum chemistry and haematology values from 2529 adults and 694 children and adolescents obtained from two studies conducted in Liberia between 2015 to 2017 were used to determine reference limits. After removing outliers, the reference limits defined by the 2.5th and 97.5th percentiles were determined by sex in three age groups (6-11, 12-17, and 18+ years). Results The median (interquartile range) of adults was 29 (23, 37) years; 44% were female. The median (interquartile range) for children and adolescents was 12 (9, 15) years; 53% were female. Several reference ranges determined using Liberian participants differed from those in the US. For chemistries, a high percentage of both adults and children/adolescents had high serum chloride levels based on United States ranges. For haematology, a high percentage of Liberian participants had haemoglobin and related assays below the lower limit of United States ranges. Conclusion Chemistry and haematology reference intervals determined for a Liberian population of healthy individuals should be considered for establishing eligibility criteria and monitoring of laboratory adverse events for clinical trials as well as for use in clinical settings in Liberia and perhaps for other countries in Western Africa.
NASH (NALFD?) and Hepatic control of glucose metabolism (2010)

"NASH (NALFD?) and Hepatic control of glucose metabolism." Journal of the American College of Nutrition, 29(4), p. 438
In Vivo Infectivity of Baculovirus Isolates, Variants, and Natural Recombinants in Alternate Hosts1 (1982)

A total of eight isolates, including variants and natural recombinants of Autographa californicaM NPV (Ac M NPY) for which genetic markers or physical maps are known were tested for in vivo virulence, and maintenance of genetic characteristics after infection of Trichoplusia ni (Hübner) (Lepidoptera: Noctuidae) and Heliothis virescens (F.) (Lepidoptera: Noctuidae) larvae. Only one of the isolates was more virulent to T. ni than the wild type; however it was less virulent to H. virescens . One recombinant (AR-66) exhibited low production of polyhedra in TN368 cells, which were used for production of the polyhedra. One variant (Ac M NPY-S1) with an insertion of DNA when compared with the Ac M NPVE2 variant was at least 9.2 times less virulent than the wild isolate. After one in vivo passage of Ac M NPY-S1, a new variant (Ac M NPY-S1a) was detected with a new Eco-R1 fragment of 2.17 Mdal and a corresponding loss of a 1.55-Mdal Eco-R1 fragment found in the parental type.