gebhart/patrepeval huggingface dataset:
Identification dans le sang de patients allergiques aux pollens de graminées d’une signature moléculaire qui corrèle avec l’efficacité clinique de l’immunothérapie allergénique (2016)

L’efficacité de l’immunothérapie allergénique (ITA) par voie sublinguale des allergies respiratoires de type I est à ce jour bien documentée chez l’homme. Néanmoins, des marqueurs biologiques de suivi d’efficacité de l’ITA restent à identifier. Des marqueurs associés aux cellules dendritiques régulatrices (CDregs) ou pro-allergéniques de type 2 (CD2s) ont été sélectionnés après une analyse différentielle du transcriptome et du protéome de ces cellules. Dans le cadre d’une étude clinique d’ITA sublinguale randomisée en double insu contre placebo, menée dans une chambre à pollen, nous avons analysé ces marqueurs biologiques au niveau des cellules du sang périphérique de patients allergiques aux pollens de graminées. En particulier, les cellules mononucléaires du sang périphérique prélevées avant et après 4 mois d’ITA ont été purifiées et l’expression de ces marqueurs a été analysée par qPCR quantitative chez 80 adultes allergiques aux pollens de graminées traités avec un placebo ou un comprimé d’extrait de 5 graminées. L’expression de marqueurs associés aux CD2s comme la thrombomoduline (CD141), GATA3, OX40 ligand et RIPK4 diminue dans le sang périphérique après traitement chez les patients répondeurs tandis que l’expression des marqueurs associés aux CDregs comme C1Q, Stabilin-1, FcgRIIIA et FTL est surexprimée. Des analyses statistiques utilisant des courbes ROC ont permis d’établir une combinaison optimale de 5 marqueurs incluant 3 marqueurs CD2s (i.e. CD141, GATA3 et RIPK4) et 2 marqueurs CDregs (i.e. C1QA et FcgRIIIA) afin de mieux identifier les patients répondeurs des non répondeurs. Cette étude souligne l’intérêt de suivre des marqueurs associés aux CDs dans le sang périphérique afin de documenter un changement précoce de balance entre réponses immunitaires régulatrices versus pro-allergiques au cours de l’ITA. Cette étude nous a permis de définir un ensemble de marqueurs biologiques facilement détectables dans le sang de patients allergiques dont l’expression corrèle avec l’efficacité clinique après ITA. De tels marqueurs permettent de mieux identifier les patients répondeurs des non répondeurs au cours des premiers mois d’ITA.
NEW APPROACHES OF THE FORECAST OF THE AGEING OF PLASMA JET NOZZLE IN INDUSTRIAL SETTINGS OF THERMAL SPRAYING (2011)

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The preparation and properties of bovine enterokinase. (1979)

Bovine enterokinase was purified from duodenal mucosa. The purification included an initial extraction with 2% deoxycholate, ammonium sulfate fractionations, DEAE-cellulose chromatography, and affinity chromatography on basic pancreatic trypsin inhibitor (Kunitz) (PTI)-Sepharose. The purified enzyme contained 35% carbohydrate; it had a molecular weight of 150,000, with a heavy (115,000) and light (35,000) chain connected by one or more disulfide bonds. Enterokinase hydrolyzed lysine and arginine substrates and slowly reacted with the trypsin active site titrant 4-methylumbelliferyl-p-guanidinobenzoate. The enzyme activated bovine trypsinogen with kinetic parameters similar to those of other preparations of enterokinase. Bovine enterokinase was inhibited by Kunitz pancreatic trypsin inhibitor with a Kassoc of 2 X 10(8) M-1 and only weakly by other proteinase inhibitors. The amino acid composition differed from bovine enterokinase isolated from duodenal contents (Anderson, L.E., Walsh, K.A., and Neurath, H. (1977) Biochemistry 16, 3354-3360). The mucosal enzyme and the duodenal contents enzymes also differed in the size of the heavy and light chains. The mucosal enterokinase more closely resembled the properties of porcine enterokinase (Baratti, J., Maroux, S., Louvard, D., and Desnuelle, P. (1973) Biochim. Biophys. Acta 315, 147-161). The amino acid composition and size of the light chain were also similar to bovine trypsin.
Exposure-response analysis of pregabalin add-on treatment of patients with refractory partial seizures (2003)

Pregabalin add-on treatment demonstrates a dose-response relationship in 3 out of 4 patients with refractory partial seizures. A dose of 186 mg pregabalin daily is expected to decrease the seizure rate by 50% of maximum from baseline. Age, race, and menopausal status of women did not affect the dose-response relationship.
In-Cylinder Flow Correlations Between Steady Flow Bench and Motored Engine Using Computational Fluid Dynamics (2016)

Intake port flow performance plays a substantial role in determining the volumetric efficiency and in-cylinder charge motion of a spark-ignited engine. Steady-state flow bench and motored engine flow CFD simulations were carried out to bridge these two approaches for the evaluation of port flow and charge motion (such as discharge coefficient, swirl/tumble ratios). A one dimensional block analytical model was used to mimic the downstream honeycomb in a flow bench experiment, which forced the flow motion in one direction. The intake port polar velocity profile and polar physical clearance profile were generated to evaluate the port performance based on local flow velocity and physical clearance in the valve-seat region. The measured data were taken from standard steady-state flow bench tests of an intake port. When using an appropriate mesh resolution near the walls, the steady-state flow bench simulation predicted that discharge coefficient and swirl/tumble index are in agreement with the measured data. It was reconfirmed that the predicted discharge coefficients and swirl/tumble index of steady flow bench simulations have a good correlation with those of motored engine flow simulations. The polar velocity inhomogeneity factor correlates well with the port discharge coefficient, swirl/tumble index. A port performance evaluation guideline was generated by taking advantage of steady flow bench and motored engine flow simulations and port polar velocity inhomogeneity factor.
Overexpression of ribosomal protein L15 is associated with cell proliferation in gastric cancer (2006)

RPL15 promotes cell proliferation and may be a potential target for anticancer therapy of gastric cancer.
The Intracellular DNA Sensor IFI16 Gene Acts as Restriction Factor for Human Cytomegalovirus Replication (2012)

Human interferon (IFN)-inducible IFI16 protein, an innate immune sensor of intracellular DNA, modulates various cell functions, however, its role in regulating virus growth remains unresolved. Here, we adopt two approaches to investigate whether IFI16 exerts pro- and/or anti-viral actions. First, the IFI16 gene was silenced using specific small interfering RNAs (siRNA) in human embryo lung fibroblasts (HELF) and replication of DNA and RNA viruses evaluated. IFI16-knockdown resulted in enhanced replication of Herpesviruses, in particular, Human Cytomegalovirus (HCMV). Consistent with this, HELF transduction with a dominant negative form of IFI16 lacking the PYRIN domain (PYD) enhanced the replication of HCMV. Second, HCMV replication was compared between HELFs overexpressing either the IFI16 gene or the LacZ gene. IFI16 overexpression decreased both virus yield and viral DNA copy number. Early and late, but not immediate-early, mRNAs and proteins were strongly down-regulated, thus IFI16 may exert its antiviral effect by impairing viral DNA synthesis. Constructs with the luciferase reporter gene driven by deleted or site-specific mutated forms of the HCMV DNA polymerase (UL54) promoter demonstrated that the inverted repeat element 1 (IR-1), located between -54 and -43 relative to the transcription start site, is the target of IFI16 suppression. Indeed, electrophoretic mobility shift assays and chromatin immunoprecipitation demonstrated that suppression of the UL54 promoter is mediated by IFI16-induced blocking of Sp1-like factors. Consistent with these results, deletion of the putative Sp1 responsive element from the HCMV UL44 promoter also relieved IFI16 suppression. Together, these data implicate IFI16 as a novel restriction factor against HCMV replication and provide new insight into the physiological functions of the IFN-inducible gene IFI16 as a viral restriction factor.
Complexity Analysis of Block Equalization Approach for PolMux QAM Coherent Systems (2011)

The computational load of block CMA equalizers is addressed. Compared to the adaptive CMA, we show block approaches increase the convergence speed by ∼ 10 but only the complexity by ∼ 4 in 112Gbit/s PolMux 16QAM systems.
Robust adaptive beamforming based on response vector optimization (2014)

In this paper, a robust beamforming method is proposed. This method can be viewed as a LCMV beamformer with its response vector further optimized. To generate a better response vector, it is first established as a non-convex quadratically constrained quadratic programming problem, and then is transformed into a semidefinite programming problem which can be efficiently and exactly solved via semidefinite relaxation. This method outperforms the traditional LCMV beamformer with lower sidelobe and well-maintained mainbeam. Moreover, the computation complexity is negligible because the size of the response vector is relatively small. Simulation examples are carried out to demonstrate the effectiveness of the proposed method.
SFQ Propagation Properties in Passive Transmission Lines Based on a 10-Nb-Layer Structure (2009)

We have studied single-flux-quantum (SFQ) propagation properties in passive transmission lines (PTLs) based on a 10-Nb-layer device structure (ADP2). In ADP2, we can use the PTLs with a line width about 5 mum, one seventh of conventional line width by adopting a strip line (SL) structure and increasing the characteristic impedance. The evaluation has been conducted on the PTL length and the via-hole structure by using ring oscillators. We found that the decrease in the operating region was larger for longer PTL, compared with that in a conventional device structure (STD2). The results would be caused by the increase in the surface resistance. The via-holes connecting the PTLs on different layers have more complicated structure than those of STD2. We have designed the via-hole structure using the electromagnetic wave simulator HFSS. As a result, we have demonstrated sufficiently large operating margins at any data rates up to 80 Gb/s even for the ring oscillator with 30 via-holes.
Long-period signal processing results for the large aperture seismic array (1969)

Abstract Results of off-line signal processing experiments are presented for long-period data obtained from the Large Aperture Seismic Array in eastern Montana. The signal-to-noise ratio gains are presented for body-wave as well as surface-wave phases. Several recommendations are made concerning optimum long-period array configurations and on-line or off-line processing methods. The usefulness of maximum likelihood processing in suppressing an interfering teleseism is demonstrated. The matched filtering of surface waves using chip waveforms is shown to be highly effective. A useful discriminant for distinguishing between natural seismic events and underground nuclear explosions, using both long-period and short-period data, was found to be the relation between surface-wave and body-wave magnitudes. Measurements of this discriminant made on events from four tectonic regions of the Earth are presented.
A software platform for genetic algorithms based parameter estimation on digital sound synthesizers (2011)

In this research, we introduce a general-purpose sound synthesis architecture for parameter estimation system, which is employing genetic algorithms (GA), to search the parameter space for different digital sound synthesizer topologies. Based on the architecture, we have implemented the software using the SuperCollider audio synthesis and programming environment and conducted several experiments. Primary consideration of the implementation was a modular and flexible structure of the framework that may open wide-range of opportunities for musicians and researchers in the field.
The compiler for supporting multithreading in cyclic register windows (2002)

This paper presents the compilation technique to support the P&M (pipelining and multithreading) multithreaded program execution model on the SPARC processor, which has cyclic register windows. The program execution model improves the performance by running multiple user-level threads on each processor and filling the idle cycles that would otherwise be wasted waiting for messages. The integrated compilation paradigm is described systematically. The generated code is efficient, which obtains rapid context switching without sacrificing the benefit of fast procedure call.
Deficiency in Rhabdomyosarcomas of a Factor Required for MyoD Activity and Myogenesis (1993)

Rhabdomyosarcoma cells express the myogenic helix-loop-helix proteins of the MyoD family but do not differentiate into skeletal muscle cells. Gel shift and transient transfection assays revealed that MyoD in the rhabdomyosarcoma cells was capable of binding DNA but was relatively nonfunctional as a transcriptional activator. Heterokaryon formation with fibroblasts resulted in the restoration of transcriptional activation by MyoD and the differentiation of the rhabdomyosarcoma cells into skeletal muscle cells. These results suggest that rhabdomyosarcomas are deficient in a factor required for MyoD activity.
A multicentre, randomised, double-blind, single-dose study assessing the efficacy of AMC/DCBA Warm lozenge or AMC/DCBA Cool lozenge in the relief of acute sore throat (2011)

ISRCTN: ISRCTN00003567.
A 30/35 GHz Dual-Band Transmitter for Phased Arrays in Communication/Radar Applications (2015)

A fully integrated single-channel transmitter is proposed for 30/35 GHz dual-band operation for communication/radar phased array systems. Implemented in a 0.25 μm BiCMOS technology, the transmitter achieves 10° phase shift resolution and 5 bit amplitude resolution suitable for advanced beamforming algorithms for suppression and nulling of side lobes. The integration covers from the baseband I/Q modulation to the RF output, including a low phase noise on-chip VCO and dual-band LO generation circuitry. An RF output power of > +14.5 dBm is achieved in both frequency bands by a linear power amplifier. The core circuit occupies a die area of 1.1 mm 2 and consumes 222-241 mA current from a 3.3 V supply.
Protein Binding Study of Perillyl Alcohol Enantiomers by High Performance Frontal Analysis (2003)

Abstract High‐performance frontal analysis (HPFA) was used for protein binding study of perillyl alcohol (POH) enantiomers to human serum albumin (HSA). The analysis was performed on a Develosil 100‐Diol‐5 (10 cm × 4.6 mm I.D.) column. Sodium phosphate solution (pH 7.4, ionic strength 0.17) was used as the mobile phase at a flow rate of 1 mL/min. UV wavelength was set at 205 nm. An injection volume of 600 µL was chosen to ensure the drug to be eluted as a trapezoidal peak with a plateau. Experimental data were fitted by Scatchard analysis. The binding constant (K) and binding affinity (nK) of POH enantiomers to HSA were: K = 5.20 × 106 (1/mol), nK = 1.74 × 104 (1/mol) for (S)‐POH and K = 3.71 × 106 (1/mol), nK = 1.51 × 104 (1/mol) for (R)‐POH, respectively.
Household rat infestation in urban slum populations: Development and validation of a predictive score for leptospirosis (2021)

Domestic rats are the principal reservoir for urban leptospirosis. However, few studies have identified infestation markers in slums and evaluated their predictivity for leptospirosis risk. We compared households with leptospirosis cases in Salvador, Brazil between 2007 and 2009 and their neighbors using a case control design, surveying for rodent infestation signs and environmental characteristics. With the 2007-2008 data, a conditional logistic regression modeling identified the peridomiciliar presence of rodent burrows (OR, 3.30; 95% CI, 1.50-7.26), rat feces (2.86; 1.24-6.59), runs (2.57; 1.06-6.22), households bordering abandoned houses (2.48; 1.04-6.02), and unplastered walls (2.22; 1.02-6.02) as risk factors and developed a predictive score for leptospirosis. With an independent data set from 2009, a receiver operating characteristic (ROC) curve analysis evaluated the prediction score performance, with the area under the curve being 0.70 (95% CI, 0.64-0.76) for score development and 0.71 (0.65-0.79) for validation. Results indicate that high proportions of urban slum households are infested with R. norvegicus. The score performed well when identifying high-risk households within slums. These findings need confirmation in other urban centers, but suggest that community-based screening for rodent infestation can allow to target rodent and environmental control measures in populations at highest risk for leptospirosis.
Mesenchymal stem cell-based tissue engineering of small-diameter blood vessels (2011)

The aim of the study was to construct small-diameter vascular grafts using canine mesenchymal stem cells (cMSCs) and a pulsatile flow bioreactor. cMSCs were isolated from canine bone marrow and expanded ex vivo. cMSCs were then seeded onto the luminal surface of decellularized arterial matrices, which were further cultured in a pulsatile flow bioreactor for four days. Immunohistochemical staining and scanning electron microscopy was performed to characterize the tissue-engineered blood vessels. cMSCs were successfully seeded onto the luminal surface of porcine decellularized matrices. After four-day culture in the pulsatile flow bioreactor, the cells were highly elongated and oriented to the flow direction. Immunohistochemistry demonstrated that the cells cultured under pulsatile flow expressed Von Willebrand factor, an endothelial cell marker. In conclusion, cMSCs seeded onto decellularized arterial matrices could differentiate into endothelial lineage after culturing in a pulsatile flow bioreactor, which provides a novel approach for tissue engineering of small-diameter blood vessels.
Elastic Plastic and Damage Model for Concrete Materials: Part II: Elastic Plastic and Damage Model for Concrete Materials: Part II: (2009)

In this companion article, we present, within the finite element context, the numerical algorithms for the integration of the thermodynamically consistent formulation of the elastic plastic and damage model for concrete materials derived in part I of this work. The proposed unified integration scheme is based on the spectral return-mapping algorithm accounting for the use of the principal stresses along with the stress tensor invariants. An operator split structure is used, consisting of a trial stress state followed by corrector steps applied through imposing the generalized plastic and damage consistency conditions. Furthermore, a trivially incrementally objective integration scheme is established for the rate constitutive relations. The proposed elastic-predictor and uncoupled plastic and damage corrector algorithms allow for a straightforward integration scheme that can be easily implemented into the existing finite element codes. The nonlinear algebraic system of equations is solved by consistent linearization and the Newton–Raphson iteration scheme. The proposed model is implemented in the implicit finite element code ABAQUS via the user subroutine UMAT. Model capabilities are illustrated through its application to the analysis of Reinforced Concrete (RC) beams tested experimentally and available in literature. The simulated results illustrate the potential of the proposed model in dealing with the reduction of the effect of the well known mesh sensitivity problem through the application of the fracture energy concept-related parameters.
Differential induction of apoptosis in lymphoid tissues during sepsis: variation in onset, frequency, and the nature of the mediators (1996)

Apoptosis (Ao), is a process by which cells undergo a form of nonnecrotic cellular suicide. Although for most cells this is a constitutive process, it can be induced in immature and differentiating immune cell populations by stress mediators associated with inflammation. This inducible form of A(o) is referred to as programmed cell death. However, it is not clear whether hematopoietic cell populations such as the thymus and bone marrow are induced to undergo A(o) during polymicrobial sepsis. To assess this, thymocytes, bone marrow cells, or splenocytes (as a source of comparative nonhematopoietic cells) were harvested from C3H/HeN mice at 1, 4, or 24 hours after cecal ligation and puncture (CLP; to induce polymicrobial sepsis) or sham-CLP (Sham). The results showed that mixed bone marrow cells ex vivo, although not to the same extent as thymus, showed a marked increase in the percentage of cells in A(o), increased endonuclease activity, and a significant decrease in cell yield at 24 hours but not at 4 hours after CLP. Similar changes were not evident in splenocytes. Phenotypic, as well as morphologic assessment, indicated that most of the increase in apoptotic cells in the thymus was associated with the immature T cells (CD4+CD8+) and CD8-CD4- cells. In contrast, the increase in bone marrow cell A(o) was associated with only the B220+ cells, with no significant contribution from myeloid cells. Treatment of CLP mice in vivo with either RU-38486 or PEG-(rsTNF-R1)2 was unable to reverse the increased A(o) in the bone marrow of these animals. Taken together, these findings indicate that A(o) as a process induced by polymicrobial sepsis is not limited to the thymus, but can also be detected in the bone marrow. However, unlike thymic A(o), bone marrow is not affected directly/indirectly by glucocorticoids or tumor necrosis factor released during sepsis.
Clinical action measures improve the reliability of feedback on quality of care in diabetes centres: a retrospective cohort study (2016)

Judging quality of diabetes care of a centre based on a TM may be misleading. Low-complexity data available from a quality improvement initiative can be used to construct a more fair and feasible measure of quality of care.
Tin(II) Chloride (2005)

[7772-99-8] Cl2Sn (MW 189.61) InChI = 1S/2ClH.Sn/h2*1H;/q;;+2/p-2 InChIKey = AXZWODMDQAVCJE-UHFFFAOYSA-L (reducing agent for many functional groups; carbonyl allylation; Lewis acid catalyst in C–C bond-forming reactions; catalyst with AgClO4 for the synthesis of α-glycosides; synthesis of alkenes, dienes, cis-vinyloxiranes, and allylic selenides; deoxygenation of 1,4-endoperoxides; protection of carboxylic acids as 1,3-dithianes; selective p-methoxybenzyl ether cleavage reagent; additive in hydroformylation and carbonylation reactions1) Alternate Name: stannous chloride. Physical Data: mp 246.8 °C; bp 623 °C; d 3.95 g cm−3. Solubility: insol xylenes; sol water, ethanol, acetone, diethyl ether, methyl acrylate, methyl ethyl ketone, isobutyl alcohol. Form Supplied in: white crystalline solid; widely available. Preparative Methods: analytical reagent grade tin(II) chloride is prepared by adding the dihydrate to a vigorously stirred solution of acetic anhydride (120 g salt per 100 g anhydride). After ca. one hour, the anhydrous SnCl2 is filtered on a dry sintered glass or Buchner funnel, washed free from acetic acid with dry Et2O, and dried in vacuo. It is best stored in a sealed container.2