gebhart/patrepeval huggingface dataset:
Managing Age-related Changes in Device Radiation-Response. (2008)

Abstract not provided.
Accelerated domain switching speed in single-crystal LiNbO3 thin films (2015)

By using ionic implantation and wafer bonding technologies, we peeled off a single-crystal LiNbO3 thin film in the atomic-layer smoothness from the surface of a bulk Z-cut LiNbO3 single crystal. X-ray diffraction patterns showed only (00l) orientation of the film. From positive-up-negative–down pulse characterization, we measured domain switching current transients under various short-pulse voltages, where we observed domain switching currents to occur separately at time after initial capacitor charging currents. This is similar to early observations in bulk ferroelectric single crystals, where apparent positive/negative coercive fields of domain switching determined from polarization-electric field hysteresis loops always equal maximum/minimum applied fields. However, after pulse stressing of the film for more than 1000 cycles, the domain switching speed is accelerated, where domain switching current overlaps with the initial capacitor charging current with a well-defined coercive field independent of the applied-field strength. Finally, we simulated the whole domain switching current transients with the assumption of the resistance degradation across interfacial passive layers between the film and electrodes.
Catalytic properties of a hybrid between cyanobacterial large subunits and higher plant small subunits of ribulose bisphosphate carboxylase-oxygenase. (1985)

The small subunits of spinach ribulosebisphosphate carboxylase-oxygenase were isolated by mild acid precipitation of the hexadecameric holoenzyme. About one-third of the small subunits remained in the supernatant while the remainder, and all of the large subunits, were precipitated and irreversibly denatured. The spinach small subunits were able to reassemble with the large subunit octamer of ribulosebisphosphate carboxylase-oxygenase from the cyanobacterium, Synechococcus ACMM 323, prepared as described previously (Andrews, T. J., and Ballment, B. (1983) J. Biol. Chem. 258, 7514-7518) to produce a catalytically active, hybrid enzyme. The heterologous small subunits bound an order of magnitude less tightly than homologous small subunits and the specific activity of the hybrid, when fully saturated with foreign small subunits, was about half that of the homologously reassembled or native Synechococcus enzyme. In addition, the Km(CO2) of the hybrid was about twice as high. However, the degree of partitioning between carboxylation and oxygenation was identical for the hybrid, the homologously reassembled, and the native Synechococcus enzymes and clearly less in favor of carboxylation than partitioning by the spinach enzyme. Therefore, this important facet of catalysis by ribulosebisphosphate carboxylase-oxygenase appears to be specified exclusively by the large subunit.
Supplementary Data from Randomized Controlled Trial of the Gastrin/CCK<sub>2</sub> Receptor Antagonist Netazepide in Patients with Barrett's Esophagus (2023)

&lt;p&gt;Supplementary Figure 1 and Supplementary Tables 1-3&lt;/p&gt;
Optimal Conditions for Fast Charging and Long Cycling Stability of Silicon Microwire Anodes for Lithium Ion Batteries, and Comparison with the Performance of Other Si Anode Concepts (2013)

Cycling tests under various conditions have been performed for lithium ion battery anodes made from free-standing silicon microwires embedded at one end in a copper current collector. Optimum charging/discharging conditions have been found for which the anode shows negligible fading (&lt; 0.001%) over 80 cycles; an outstanding result for this kind of anodes. Several performance parameters of the anode have been compared to the ones of other Si anode concepts, showing that especially the capacity as well as the rates of charge flow per nominal area of anode are the highest for the present anode. With regard to applications, the specific parameters per area are more important than the specific gravimetric parameters like the gravimetric capacity, which is good for comparing the capacity between materials but not enough for comparing between anodes.
Designs and Prospects of Bi-2212 Canted-Cosine-Theta Magnets to Increase the Magnetic Field of Accelerator Dipoles Beyond 15 T (2018)

The critical current density of Bi-2212 round wires has seen significant improvement over the past two years. We present the magnetic design and stress analysis of two Bi-2212 dipoles based on Canted-Cosine-Theta (CCT) technology using the state-of-the-art wires. The first design, based on a 19-strand Rutherford cable of 00.8 mm strands, is a two-layer dipole with a bore diameter of 40 mm and an outer diameter of 98.4 mm; it generates 5.4 T when operating in stand-alone configuration and 18.9 T in 15 T background field. The second design, based on a 13-strand Rutherford cable of 00.8 mm strands, is also a two-layer dipole with a bore diameter of 40 mm and an outer diameter of 81 mm; it generates 4.0 T when operating in stand-alone configuration and 17.8 T in 15 T background field. Normal stresses on the conductor in these magnets do not exceed 35 MPa when working under background field. Moreover, we propose a novel approach for increasing the efficiency of CCT magnets using keystoned Rutherford cable while removing the midplane ribs. With this method, it is possible to increase the efficiency of small radius CCT coils by 20%. We conclude that Bi-2212 can be used to increase the limit of accelerator magnet dipole fields beyond 15 T while managing stresses in the coils to acceptable levels.
Cation–cation bonding in nitrenium metal complexes (2013)

Nitrenium ligands provide an excellent platform for the straightforward and efficient synthesis of extremely rare complexes that possess positively charged ligands coordinated to positively charged metals. Examples of stable cation–cation and cation–dication coordination bonds are demonstrated. Computational studies show that such bonding is greatly stabilized by its incorporation into a tridentate frame, as well as the use of polar solvents.
Skin reactions to human papillomavirus (HPV) 16 specific antigens intradermally injected in healthy subjects and patients with cervical neoplasia (2008)

We have tested the safety and feasibility of a synthetic long peptide-based HPV16-specific skin test to detect cellular immune responses to HPV16 E2, E6 and E7 in vivo. Women with cervical neoplasia (n = 11) and healthy individuals (n = 19) were intradermally challenged with 8 different pools of HPV16 E2, E6 and E7 peptides. The skin test was safe as the injections were perceived as mildly painful and no adverse events were observed. The majority of skin reactions appeared significantly earlier in HPV16+ patients (<8 days) than in healthy subjects (8-25 days). The development of late skin reactions in healthy subjects was associated with the appearance of circulating HPV16-specific T cells and the infiltration of both HPV16-specific CD4+ Th1/Th2 and CD8+ T cells into the skin. These data show that the intradermal injection of pools of HPV16 synthetic long peptides is safe and results in the migration of HPV16-specific T cells into the skin as well as in an increase in the number of circulating HPV16-specific T cells. The use of this test to measure HPV16-specific immunity is currently tested in a low resource setting for the measurement of spontaneously induced T-cell responses as well as in our HPV16 vaccination trials for the detection of vaccine-induced immunity.
Investigation of ignition temperature, time to ignition and chip morphology after the high-speed dry milling of magnesium alloys (2016)

Abstract Purpose The purpose of this paper is to determine time-to-ignition of magnesium alloy chips and the ignition-preceding stages as well as to examine chip morphology. The tests were conducted according to the following pattern: directly after a milling operation, after ignition using a special test stand located outside the machine tool and after intensive oxidation which prevented ignition. Design/methodology/approach Milling is a machining process widely used in the manufacturing of various parts that are applied, e.g. in the aircraft industry. Milling is used for both roughing and finishing machining. In the dry machining of magnesium alloys, spontaneous ignition can occur; therefore, the analysis of chip temperature in the cutting area is of great significance. Additionally, time-to-ignition and chip morphology are crucial when considering the safety of magnesium alloy machining processes. Findings The experimental results demonstrate the effect of parameters of the milling process on time-to-ignition of chips made of magnesium alloys AZ31 and AZ91HP. The experiments also involved examining the morphology of a selection of chips produced at the maximum cutting velocity vc and feed per tooth fz. In addition, we analysed the morphology of both ignition products and chips subjected to high temperature where ignition did not occur. Practical Implications Based on the time-to-ignition and chip morphology results, it is possible to indicate both safety levels in machining and the efficient range of parameters in the milling of aircraft parts made of magnesium alloys. Originality/value The paper presents a new approach to assessing safety in milling operations. The results of the tests of chip flammability (time-to-ignition) which were run at a special test stand placed outside the machine tool enabled determination of both safety and efficiency range of the milling process.
The effect of sand surface treatment on sand‐filled composites (1988)

Abstract Sand/unsaturated polyester composites, 50/50 composition by weight, were prepared from sand treated with different silane solutions. N‐2‐aminoethyl‐3‐aminopropyl‐trimethoxy silane (A0700) and 3‐aminopropyltriethoxy silane (A0750) were used. Water and styrene solutions were employed to treat the sand. It was found that A0750 in styrene produced better composites than other surface treatments. As the interfacial bond was improved, the tensile strength and the tensile modulus increased whereas the strain to failure decreased. The acoustic emission data was a function of the sand surface treatment where a better interfacial bond resulted in more acoustic activity. Dynamic mechanical analysis showed that the interfacial bond affects the dynamic shear modulus, the loss shear modulus, and the damping of the sand‐filled composites. The glass transition temperature ( T g ) of the composite was also affected by the surface treatment. The thermogravimetric analysis did not show a well‐defined trend between the decomposition temperature and the surface treatment.
L'utilisation de l'ordinateur dans l'enseignement primaire : l'exemple de la France (1985)

Rapport redige a la demande du conseil de l'Europe qui decrit actions et initiatives qu'a provoque l'introduction de la microinformatique a l'ecole elementaire et qui ont ete l'objet de projet de recherche
Multimodal tuned dynamic absorber for split Stirling linear cryocooler (2017)

Forthcoming low size, weight, power and price split Stirling linear cryocoolers may rely on electro-dynamically driven single-piston compressors and pneumatically driven expanders interconnected by the configurable transfer line.
Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970–2016: a systematic analysis for the Global Burden of Disease Study 2016 (2017)

Bill & Melinda Gates Foundation, and the National Institute on Aging and the National Institute of Mental Health of the National Institutes of Health.
Radioimmune determination of hypoxanthine phosphoribosyltransferase crossreacting material in erythrocytes of Lesch-Nyhan patients. (1975)

We have developed a sensitive radioimmunoassay capable of detecting and quantitating 20 ng of hypoxanthine phosphoribosyltransferase (EC 2.4.2.8; IMP:pyrophosphate phosphoribosyltransferase) protein. For this assay, hypoxanthine phosphoribosyltransferase from human erythrocytes was iodinated with 125I under mild conditions using hydrogen peroxide and lactoperoxidase attached to Sepharose-4B. Antisera prepared against homogeneous human hypoxanthine phosphoribosyltransferase precipitates the iodinated enzyme as effectively as the unlabeled enzyme. The radioimmunoassay has been used to look for hypoxanthine phosphoribosyltransferase crossreacting material in hemolysates from sixteen different patients with a marked genetic deficiency of this enzyme characteristic of the Lesch-Nyhan syndrome. Fifteen hemolysates contained no detectable (less than 1% of normal) crossreacting material. One hemolysate contained a normal amount of crossreacting material. Hypoxanthine phosphoribosyltransferase from this patient (E.S.) has been shown to be a Km mutant enzyme.
Photonic crystal fiber modal interferometer for biosensing applications (2011)

We fabricate and demonstrate a refractometer based on photonic crystal fiber (PCF) modal interferometer. The streptavidin and biotin are used as analyte and receptor in the experiment. The fabrication of the sensor is carried out via micro-hole collapsing with straightforward fusion arc splicing technique. Both sides of a short length of PCF (∼3 mm) are spliced to conventional single mode fibers (SMF). The voids of the PCF are completely collapsed in the splice region, acting as mode splitter and combiner for the PCF modal interferometer. The bulk liquid sensitivity is about 70.2 nm/RIU (refractive index unit) based on the linear curve fit for refractive index ranging from 1.33 to 1.35. The transmission spectrum of the biotin modified PCF modal interferometer exhibits 0.8 nm wavelength shift after streptavidin and biotin binding occurs.
GaN MSM Ultraviolet Photodetectors with Transparent and Thermally Stable RuO[sub 2] and IrO[sub 2] Schottky Contacts (2004)

Ruthenium oxide and iridium oxide were used as the Schottky barrier materials of GaN metal-semiconductor-metal (MSM) ultraviolet photodetector. After annealing Ru and Ir contacts at 500 degreesC under O-2 ambient, the reverse leakage current density at -5 V drastically decreased by four orders of magnitude. Furthermore, the Schottky barrier height and optical transmittance at 360 nm simultaneously increased to 1.43 eV and 71.5% for the Ru, and to 1.48 eV and 74.8% for the Ir contact. The dramatic improvements originated from the formation of thermally stable oxide phases, RuO2 and IrO2, by the annealing, resulting in the increase in the responsivity of the GaN MSM photodetector by one order of magnitude in comparison with the photodetector with Pt Schottky contact. (C) 2004 The Electrochemical Society.
Homologous Chromosome Pairing in Drosophila melanogaster Proceeds through Multiple Independent Initiations (1998)

The dynamics by which homologous chromosomes pair is currently unknown. Here, we use fluorescence in situ hybridization in combination with three-dimensional optical microscopy to show that homologous pairing of the somatic chromosome arm 2L in Drosophila occurs by independent initiation of pairing at discrete loci rather than by a processive zippering of sites along the length of chromosome. By evaluating the pairing frequencies of 11 loci on chromosome arm 2L over several timepoints during Drosophila embryonic development, we show that all 11 loci are paired very early in Drosophila development, within 13 h after egg deposition. To elucidate whether such pairing occurs by directed or undirected motion, we analyzed the pairing kinetics of histone loci during nuclear cycle 14. By measuring changes of nuclear length and correlating these changes with progression of time during cycle 14, we were able to express the pairing frequency and distance between homologous loci as a function of time. Comparing the experimentally determined dynamics of pairing to simulations based on previously proposed models of pairing motion, we show that the observed pairing kinetics are most consistent with a constrained random walk model and not consistent with a directed motion model. Thus, we conclude that simple random contacts through diffusion could suffice to allow pairing of homologous sites.
Trewia nudiflora Linn, a Medicinal Plant: Allelopathic Potential and Characterization of Bioactive Compounds from Its Leaf Extracts (2023)

Trewia nudiflora Linn. is a valuable forest resource due to its economic, ethnomedicinal, and ecological properties; however, its allelopathic potential is undocumented. Therefore, this research was designed to investigate the allelopathic impacts of T. nudiflora leaf extracts on alfalfa (Medicago sativa L.) and barnyard grass (Echinochloa crus-galli (L.) P. Beauv.) growth, as well as to isolate and to identify the active allelopathic substances responsible for these effects. A bioassay experiment with eight different treatments (0.1, 0.3, 1, 3, 10, 30, 100, and 300 mg dry weight (DW) equivalents of T. nudiflora extracts in mL−1) was carried out. The results showed that the growth of both plants decreased with increasing contents of T. nudiflora extracts, with the effect depending on the plant species and reaching its peak at a concentration of a 300 mg DW equivalent of T. nudiflora extract in mL−1. Active substances were isolated and identified using an HPLC system, which revealed the presences of methyl gallate and pinoresinol in aqueous methanol extracts of T. nudiflora. The shoot and root lengths of the alfalfa and the barnyard grass decreased significantly when they were treated with the methyl gallate and the pinoresinol. The allelopathic inhibition increased with increasing compound concentrations, with the root growth being more sensitive to the pinoresinol than to the methyl gallate, and it was significantly higher at the concentration of 10 mM. These results indicated that the T. nudiflora leaf extracts limited the growth of the treated plants, and the methyl gallate and pinoresinol in the extracts may have caused the inhibition of the T. nudiflora extracts. Thus, the leaf extracts of T. nudiflora and the substances methyl gallate and pinoresinol could be incorporated into sustainable agricultural practices or used to develop bioherbicides that would promote sustainable weed management practices.
Mooring Effect on Wave Frequency Response of Round Shape FPSO (2015)

This paper presents the motions response of moored Round Shape FPSO model due to the wave effect. The proposed of this research is analyzed the possibility of model motion response affected by different mooring system attach to the model. Model experiment was applied in this research to collect motion data for the study. Besides, the numerical simulation using diffraction potential, diffraction potential with Morison Heave correction and ANSYS frequency domain study were also applied in this research to generate comparative data to the experimental results. To investigate the effect of the mooring system to motion response, the model experiment was firstly conducted by attached model scale catenary mooring lines to Round Shape FPSO model. After that, the experiment was repeated by attached model scale taut mooring lines to the same model. The results obtain from the regular wave experiment tests and numerical simulation test were presented in this paper. This research concluded that the mooring systems would not give significant effect to wave frequency motion response after compared the motion result obtain from model experiment conducted using different mooring system.
Effect of CO2 nanobubbles incorporation on the viscosity reduction of fruit juice concentrate and vegetable oil (2021)

Abstract Viscosity is one of key parameters to handle liquid food during processing and transport. In this work, viscosities of apple juice concentrate (APJC) and canola oil (CANO) injected with CO 2 nanobubbles (NBs), having size ranged approximately from 50 to 850 nm, were investigated. A significant ( P ≤ 0.05) viscosity reduction was observed by up to 18% and 10% in APJC and CANO, respectively, after the NBs injection. When being stored at ambient (23 °C) and refrigerated (4 °C) temperatures for 7 days, the reduction effect on viscosities of samples treated with NBs tended to diminish in accordance with the growth of NBs’ size and the decrease of dissolved CO 2 concentration. Besides, the suspension of CO 2 NBs insignificantly affected pH, total soluble solid content of APJC, as well as densities of APJC and CANO. These findings suggested that utilisation of NBs can be a feasible mean to reduce viscosity and enhance processing efficiency of food fluids.
ChemInform Abstract: OPTIMUM CONDITIONS FOR THE ELECTROCHEMICAL SYNTHESIS OF AMINOMALONONITRILE (1982)

Abstract Die Phenylhydrazono‐malodinitrile (I) werden mit Methyliodid (II) zu den Methylderivaten (III) alkyliert.
VEGF and Intraocular Neovascularization: From Discovery to Therapy (2016)

I am honored and humbled to be one of the awardees of the 2014 A. Champalimaud Vision Award. I offer my heartfelt thanks to the Champalimaud Foundation President, Leonor Beleza, and to the Award Committee Members for this wonderful recognition. I feel especially fortunate to have had the opportunity to witness my scientific discoveries move from the bench to the clinic. Scientific discovery is hugely exciting, but the ability to translate that work into potentially helping someone lead a better life is even more fulfilling. This Award is dedicated to the patients.
Infiltrating T Cells Increase IDO1 Expression in Glioblastoma and Contribute to Decreased Patient Survival (2017)

<b>Purpose:</b> Indoleamine 2,3 dioxygenase 1 (IDO1) mediates potent immunosuppression in multiple preclinical models of cancer. However, the basis for elevated IDO1 expression in human cancer, including the most common primary malignant brain tumor in adults, glioblastoma (GBM), is poorly understood. The major objective of this study is to address this gap in our understanding of how IDO1 expression contributes to the biology of GBM, and whether its level of expression is a determinant of GBM patient outcome.<b>Experimental Design:</b> Patient-resected GBM, The Cancer Genome Atlas, human T-cell:GBM cocultures, as well as nu/nu, NOD-<i>scid,</i> and humanized (NSG-SGM3-BLT) mice-engrafted human GBM form the basis of our investigation.<b>Results:</b><i>In situ</i> hybridization for <i>IDO1</i> revealed transcript expression throughout patient-resected GBM, whereas immunohistochemical IDO1 positivity was highly variable. Multivariate statistical analysis revealed that higher levels of IDO1 transcript predict a poor patient prognosis (<i>P</i> = 0.0076). GBM <i>IDO1</i> mRNA levels positively correlated with increased gene expression for markers of cytolytic and regulatory T cells, in addition to decreased patient survival. Humanized mice intracranially engrafted human GBM revealed an IFNγ-associated T-cell-mediated increase of intratumoral <i>IDO1</i><b>Conclusions:</b> Our data demonstrate that high intratumoral <i>IDO1</i> mRNA levels correlate with a poor GBM patient prognosis. It also confirms the positive correlation between increased GBM <i>IDO1</i> levels and human-infiltrating T cells. Collectively, this study suggests that future efforts aimed at increasing T-cell-mediated effects against GBM should consider combinatorial approaches that coinhibit potential T-cell-mediated IDO1 enhancement during therapy. <i>Clin Cancer Res; 23(21); 6650-60. ©2017 AACR</i>.
Advances in Labour and Machinery Management (2007)

Rosana G. Moreira, Editor-in-Chief; Texas A&M University