gebhart/patrepeval huggingface dataset:
Investigation of Pseudocapacitive Charge-Storage Behavior in Highly Conductive Ordered Mesoporous Tungsten Oxide Electrodes (2011)

Herein, a pseudocapacitive charging behavior of highly conductive ordered mesoporous tungsten oxide (m-WO3-X) is investigated. For this purpose, various electrochemical analysis methods such as cyclic voltammetry (CV), galvanostatic charge–discharge experiment and electrochemical impedance spectroscopy (EIS) were employed. From CV experiment, a relationship analysis between voltammetric charge and scan rate resulted in total (67 C g–1), outer (61 C g–1) and inner charge (6 C g–1), which was related with the well-developed crystalline structure of m-WO3-X. In galvanostatic charge–discharge profiles with change of applied current, a more severe decrease of cathodic capacity than the anodic one was observed, which was attributed to larger cathodic resistance. This resistance dependency on potential was clarified with EIS fitting analysis. Here, the charge transfer resistance and Warburg diffusion resistance became larger with increasing potential, which was relevant to the change of oxidation state during redox reaction. Using these electrochemical analysis results, a schematic illustration of the pseudocapacitive charging mechanism was proposed.
A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction (2020)

COVID-19 caused by SARS-CoV-2 has become a global pandemic requiring the development of interventions for the prevention or treatment to curtail mortality and morbidity. No vaccine to boost mucosal immunity, or as a therapeutic, has yet been developed to SARS-CoV-2. In this study, we discover and characterize a cross-reactive human IgA monoclonal antibody, MAb362. MAb362 binds to both SARS-CoV and SARS-CoV-2 spike proteins and competitively blocks ACE2 receptor binding, by overlapping the ACE2 structural binding epitope. Furthermore, MAb362 IgA neutralizes both pseudotyped SARS-CoV and SARS-CoV-2 in 293 cells expressing ACE2. When converted to secretory IgA, MAb326 also neutralizes authentic SARS-CoV-2 virus while the IgG isotype shows no neutralization. Our results suggest that SARS-CoV-2 specific IgA antibodies, such as MAb362, may provide effective immunity against SARS-CoV-2 by inducing mucosal immunity within the respiratory system, a potentially critical feature of an effective vaccine.
ChemInform Abstract: Boron Analogues of Choline. Part 2. Efficient Syntheses of Boron Analogues of Choline, Acetylcholine, and Substituted Acetylcholines. (1987)

Abstract An efficient synthesis of isoelectronic and isostructural boron analogues (IIIa)‐(IIId) of choline and acylcholines from the reaction of the corresponding ester hydrochlorides (II) with Et 4 NBH 4 is described.
HEPATITIS B VIRUS INFECTION PROFILE IN CENTRAL BRAZILIAN HEMODIALYSIS POPULATION (1998)

Hepatitis B has proved to be a major health hazard in hemodialysis patients. In order to investigate the hepatitis B virus (HBV) infection profile in the hemodialysis population of Goiânia city--Central Brazil, all dialysis patients (N = 282) were studied. The prevalence of any HBV marker (HBsAg, anti-HBs, and anti-HBc) was 56.7% (95% CI: 51.1-62.7), ranging from 33.3% to 77.7% depending on dialysis unit. HBV-DNA was detected in 67.6% and 88.2% of the HBsAg-positive serum samples, in 91.3% and 100% of the HBsAg/HBeAg-positive samples, and in 18.2% and 63.6% of the HBsAg/anti-HBe-reactive sera by hybridization and PCR, respectively. The length of time on hemodialysis was significantly associated with HBV seropositivity. Only 10% of the patients reported received hepatitis B vaccination. The findings of a high HBV infection prevalence in this population and the increased risk for HBV infection on long-term hemodialysis suggest the environmental transmission, emphasizing the urgent need to evaluate strategies of control and prevention followed in these units.
Target-Induced Conjunction of Split Aptamer Fragments and Assembly with a Water-Soluble Conjugated Polymer for Improved Protein Detection (2014)

Rapid and sensitive detection of proteins is crucial to biomedical research as well as clinical diagnosis. However, so far, most detection methods rely on antibody-based assays and are usually laborious and time-consuming, with poor sensitivity. Herein, we developed a simple and sensitive fluorescence-based strategy for protein detection by using split aptamer fragments and a water-soluble polycationic polymer (poly{[9,9-bis(6'-(N,N,N-diethylmethylammonium)hexyl)-2,7-fluorenylene ethynylene]-alt-co-[2,5-bis(3'-(N,N,N-diethylmethylammonium)-1'-oxapropyl)-1,4-phenylene] tetraiodide} (PFEP)). The thrombin-binding DNA aptamer was split into two fragments for target recognition. The PFEP with high fluorescence emission was used as energy donor to amplify the signal of dye-labeled DNA probe. In the absence of target, three DNA/PFEP complexes were formed via strong electrostatic interactions, resulting in efficient Föster resonance energy transfer (FRET) between two fluorophores. While the presence of target induces a conjunction of two split aptamer fragments to form G-quadruplex, and subsequent assemble with PFEP leading to the formation of G-quadruplex/thrombin/PFEP complex. The distance between the PFEP and dye increased due to protein's large size, leading to a remarkable decrease of the FRET signal. Compared with the intact aptamer, the use of shorter split aptamer fragments increases the possibility of forming G-quadruplex upon target. Thus, the rate of change of FRET signal before and after the addition of target improved significantly and a higher sensitivity (limit of detection (LOD) = 2 nM) was obtained. This strategy is superior in that it is rapid, has low cost and homogeneous detection, and does not need heating to avoid an unfavorable secondary structure of DNA probe. With further efforts, this method could be extended to a universal way for simple and sensitive detection of a variety of biomolecules.
Image compression using multi-layer neural networks (2002)

A new neural network data compression method is presented. This work extends the use of 2-layer neural networks to multi-layer networks. Results show the performance superiority of multi-layer neural networks compared to that of the 2-layer one especially at high compression ratios. To overcome the long training time required for multi-layered networks, a recently developed training algorithm has been used. A modified feedback error is proposed to further reduce the training time and to enhance the image quality. Also, a redistribution of the gray levels in the training phase is proposed to make the minimization of the mean square error more related to the human visual system.
The DSP implementation of a new timing recovery technique for high-speed digital data transmission (2002)

An innovative digital timing recovery method for synchronous digital receivers is described. This method is based on estimating the impulse response of the channel and then choosing an optimal sampling phase from this estimate. The method uses an adaptive transversal filter (TF), operating at the baud rate and driven by a decision-directed reference, to cancel the sampled received far-end signal. This timing recovery technique connects, in a natural way, with receivers using decision feedback equalizers (DFEs). A 30-tap DFE receiver incorporating this timing recovery scheme has been simulated and implemented in real time on a single DSP (digital signal processor).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Dielectrophoretic manipulation of particles (2002)

The authors have demonstrated recently that, in general, the dielectrophoretic (DEP) force experienced by a particle has two components. The first depends upon inhomogeneities in the field strength and upon the in-phase part of the dipole moment induced in the particle by the applied electric field. This component can be identified with the conventional dielectrophoretic (cDEP) force. The second component relates to the nonuniform distribution of the phase of the field and to the out-of-phase part of the induced dipole moment. A nonuniform phase distribution corresponds to the field traveling through space. This second force component gives rise to traveling wave dielectrophoresis (twDEP). In this paper, the authors describe several electrode configurations designed to produce electric fields capable of inducing cDEP end twDEP forcer for the purpose of manipulating particles. Using DS19 Friend murine erythroleukemia cells as test particles with well characterized dielectric properties, they investigated the electrokinetic behaviors for these electrodes as a function of frequency and electrode excitation mode. Several characteristic cell electrokinetic behaviors were identified depending on the excitation characteristics of the electrodes and the cell dielectric properties including trapping linear motion, levitation and circulation of the cells. They describe these findings and rationalize them in terms of field distributions produced by the electrodes and generalized dielectrophoresis theory. The biotechnological applications of dielectrophoretic manipulation are then discussed.
Development of serum IgM antibodies against superantigens ofStaphylococcus aureusandStreptococcus pyogenesin Kawasaki disease (2006)

To serologically determine the association of microbial superantigens and the pathogenesis of Kawasaki disease (KD), we conducted a case-control study. Serum IgG and IgM antibodies against staphylococcal enterotoxin A (SEA), SEB, SEC, toxic shock syndrome toxin-1 (TSST-1), and streptococcal pyrogenic exotoxin A (SPEA) were measured by an enzyme-linked immunosorbent assay in 293 serum samples from 65 KD patients on clinical days 1-28 and 120 control samples. The administration of immunoglobulin products, which contain high concentrations of IgG antibodies against all the superantigens, directly elevated antitoxin IgG antibodies in KD patients. In contrast, antitoxin IgM antibodies were not detected in immunoglobulin products. Actually, we found a significant elevation of IgM antibodies against SEA in KD patients in the first (median titre: 0.020, P < 0.01 versus control), second (0.024, P < 0.001), third (0.030, P < 0.001) and fourth (0.038, P < 0.001) weeks, compared to the controls (0.015). Significant differences of IgM antibodies were also true for SEB, TSST-1, and SPEA throughout the first to fourth weeks, and for SEC throughout the second to fourth weeks. The prevalence of KD patients having high IgM titres (> mean + 2SD of control values) to the 5 superantigens was increased with the clinical weeks, and reached 29-43% of KD subjects at the fourth week. This is the first study that describes kinetics of IgM antibodies against superantigens and clarifies the serological significance throughout the clinical course of KD. Our results suggest that multiple superantigens involve in the pathogenesis of KD.
Nonlinear viscoelastic biomaterials: meaningful characterization and engineering inspiration (2009)

Nonlinear mechanical properties play an important role in numerous biological functions, for instance the locomotion strategy used by terrestrial gastropods. We discuss the progress made toward bioinspired snail-like locomotion and the pursuit of an engineered fluid that imitates the nonlinear viscoelastic properties of native gastropod pedal mucus. The rheological behavior of native pedal mucus is characterized using an oscillatory deformation protocol known as large amplitude oscillatory shear, and we review recently developed techniques for appropriately describing nonlinear viscoelastic behavior. Although materials that exhibit purely elastic and purely viscous nonlinearities are amenable to standard techniques for characterization, pedal mucus samples (and biomaterials in general) are viscoelastic, exhibiting both elastic and viscous nonlinear responses simultaneously and requiring advanced techniques for characterization. We reveal the utility of these new methods by examining trail mucus from the terrestrial slug Limax maximus using oscillatory shear rheology. Material responses which previously could only be described mathematically, with little physical insight, can now be interpreted with familiar language such as strain-stiffening/softening and shear-thickening/thinning. The new methodology is applicable to any complex material that can be tested using imposed oscillatory deformations. We have developed data-analysis software to enable wider use of this framework within and beyond the biomaterials community. The functionality of this software is outlined here.
Deep Contextualized Word Embeddings in Transition-Based and Graph-Based Dependency Parsing - A Tale of Two Parsers Revisited (2019)

Artur Kulmizev, Miryam de Lhoneux, Johannes Gontrum, Elena Fano, Joakim Nivre. Proceedings of the 2019 Conference on Empirical Methods in Natural Language Processing and the 9th International Joint Conference on Natural Language Processing (EMNLP-IJCNLP). 2019.
Comparative outcome of low birth weight babies. (1993)

One hundred and fifty six babies with birth weight between 1500-2000 g and 103 full term-appropriate for gestational age (FT-AGA) babies delivered at University Hospital, District Hospital and village homes were included for a comparative study of mortality, morbidity and growth pattern. The low birth weight (LBW) babies from the three centres had similar birth weight and gestational age. Neonatal mortality rates for the LBW babies were similar at the three centres. The main cause of death were infections and aspiration with rates again being similar. Diarrhea and respiratory tract infections were common causes of morbidity. The mortality rates for the LBW babies were significantly higher as compared to FT-AGA babies irrespective of the place of delivery. The incidence of morbidities like diarrhea and respiratory infections were also higher in LBW babies. However, the differences were statistically significant mostly in the preterm group. The weight gain of all LBW babies was similar up to 3 months of age. The findings of an identical outcome for the LBW babies at village level to those managed at hospitals is an encouraging trend to increasing domiciliary care for LBW babies.
Psoriasis Outcome Measures: A Report from the GRAPPA 2012 Annual Meeting (2013)

Psoriasis is a multisystem disease. The cutaneous and musculoskeletal manifestations (psoriatic arthritis) are well recognized. However, the other manifestations of psoriatic disease including metabolic syndrome, atherosclerotic cardiovascular disease, depression, poor self-esteem, and self-destructive habits including obesity, smoking and excess alcohol consumption are underappreciated. At the 2012 annual meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA), members addressed the need to develop uniform, validated, standardized outcome measures for psoriatic disease, measures that are useful to all stakeholders including patients, physicians, regulators, and payers.
Numerical Algorithm for Pólya Enumeration Theorem (2016)

Although the Pólya enumeration theorem has been used extensively for decades, an optimized, purely numerical algorithm for calculating its coefficients is not readily available. We present such an algorithm for finding the number of unique colorings of a finite set under the action of a finite group.
Isolation and mapping of the human EIF4A2 gene homologous to the murine protein synthesis initiation factor 4A-II gene <i>Eif4a2</i> (1995)

We report isolation of human cDNA highly homologous to murine Eif4a2, a gene for one of the protein-synthesis initiation factors involved in the binding of mRNA to the ribosome. This cDNA, which encodes a 407-amino-acid protein, belongs to a highly-conserved gene family, the DEAD-box gene family. The human homologue of Eif4a2 was expressed in all normal tissues examined, but in variable amounts, being highly expressed in skeletal muscle and ovary, and less abundantly in liver, kidney, and pancreas. Furthermore, we have localized the human EIF4A2 to chromosome 18p11.2 by fluorescent in situ hybridization.
Response to editorial ‘Reproducibility of cardiopulmonary exercise test variables: getting into an additional strength of the test’ (2014)

Test-retest reproducibility is a touchstone of science. Good fields do it; bad ones do not (or censor its publication). Reproducibility data is also key to research design. The standard deviation of difference of the endpoint variable is the pivotal determinant of the sample size required to detect any particular effect size at a certain power and significance level. Without openly available reproducibility data, researchers have to guess a value for this most crucial number.
α-stripping Reactions with Exotic Nuclei:12C(7Be,3He)16O (2006)

The 12C(7Be,3He)16O reaction has been studied at E(7Be)=34 MeV. At this energy this Reaction exhibits a high selectivity for populating known α‐cluster states in 16O (Jπ = 0+,3−,2+,1−,4+, and 6+). The angular distributions for the 0+,3−,2+,1−, and 4+ levels are obtained at forward angles. Likewise, large reaction rates were measured for the 3He transfer channel, i.e. 12C(7Be,α)15O.
Synthesis of phthalocyanines with an extended system of π-electron conjugation (2013)

Synthetic approaches to phthalocyanines with an extended system of π-electron conjugation are described. Compounds of planar and sandwich structure are presented that possess intensive absorption in the near-IR region of the spectrum. Particular attention is devoted to electronic absorption spectra of these systems and their correlation with structure. The bibliography includes 97 references.
Eotaxin-3 (CCL26) Expression in Human Pancreatic Myofibroblasts (2015)

Pancreatic myofibroblasts may be a cellular source of eotaxin-3 in the pancreas. The T helper type 2 cytokines, IL-4 and IL-13, are critical factors for the induction of eotaxin-3 in the pancreas.
Improved diagnostic yield for lung nodules with digital tomosynthesis‐corrected navigational bronchoscopy: Initial experience with a novel adjunct (2019)

The use of F-ENB may increase the diagnostic yield of ENB and has a low complication rate.
An Efficient Visualization Method for Polygonal Data with Dynamic Simplification (2018)

Polygonal data often require rendering with symbolization and simplification in geovisualization. A common issue in existing methods is that simplification, symbolization and rendering are addressed separately, causing computational and data redundancies that reduce efficiency, especially when handling large complex polygonal data. Here, we present an efficient polygonal data visualization method by organizing the simplification, tessellation and rendering operations into a single mesh generalization process. First, based on the sweep line method, we propose a topology embedded trapezoidal mesh data structure to organize the tessellated polygons. Second, we introduce horizontal and vertical generalization operations to simplify the trapezoidal meshes. Finally, we define a heuristic testing algorithm to efficiently preserve the topological consistency. The method is tested using three OpenStreetMap datasets and compared with the Douglas Peucker algorithm and the Binary Line Generalization tree-based method. The results show that the proposed method improves the rendering efficiency by a factor of six. Efficiency-sensitive mapping applications such as emergency mapping could benefit from this method, which would significantly improve their visualization performances.
Purification and crystallization ofVibrio fischeriCcdB and its complexes with fragments of gyrase and CcdA (2007)

The ccd toxin-antitoxin module from the Escherichia coli F plasmid has a homologue on the Vibrio fischeri integron. The homologue of the toxin (CcdB(Vfi)) was crystallized in two different crystal forms. The first form belongs to space group I23 or I2(1)3, with unit-cell parameter a = 84.5 A, and diffracts to 1.5 A resolution. The second crystal form belongs to space group C2, with unit-cell parameters a = 58.5, b = 43.6, c = 37.5 A, beta = 110.0 degrees, and diffracts to 1.7 A resolution. The complex of CcdB(Vfi) with the GyrA14(Vfi) fragment of V. fischeri gyrase crystallizes in space group P2(1)2(1)2(1), with unit-cell parameters a = 53.5, b = 94.6, c = 58.1 A, and diffracts to 2.2 A resolution. The corresponding mixed complex with E. coli GyrA14(Ec) crystallizes in space group C2, with unit-cell parameters a = 130.1, b = 90.8, c = 58.1 A, beta = 102.6 degrees, and diffracts to 1.95 A. Finally, a complex between CcdB(Vfi) and part of the F-plasmid antitoxin CcdA(F) crystallizes in space group P2(1)2(1)2(1), with unit-cell parameters a = 46.9, b = 62.6, c = 82.0 A, and diffracts to 1.9 A resolution.
VIRTUAL MANUFACTURING PROCESS ALLOCATION VIA NONLINEAR OPTIMIZATION APPROACH (2016)

This study demonstrates the evolution of optimal virtual manufacturing process via utilizing the condition of optimization tools to determine the optimum configuration of the drilling process and operations of allocation in term of distances constrains through availability of two dimensional space layout. The distribution of motherboard holes allocated was virtually investigated and an experimental of power supply plate cover is also maintained to achieve different minimum dimension which leads to alter the whole design parameters of sub components such as integrates and electric components in the main board circuit. A technique for mentioned case study is a new branch technology which will affect simultaneously many cases design attributes in the same concept such as machines allocation distribution in the plant shop floor, assignment problem, industrial geographical distribution salesman problem, perforation and transportation and other. After all iteration took place an ultimate final allocation for drilling holes in an 1.5 x1.5 cm metal cover already perforate in specific locations to perform its design need where the new distribution of the holes give an optimal space for metal cover which effect in the hole design prospect in addition to other production aspects of cost and raw material west issues.
1P-134 Crystallization of ATPsynthase(Molecular motor, The 47th Annual Meeting of the Biophysical Society of Japan) (2009)

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Laser absorption and energy transfer in foams of various pore structures and chemical compositions (2006)

Interaction of sub-nanosecond intense laser pulses with foams containing fine and large pores has been studied experimentally. Laser penetration and energy transport in the foam material are measured via streaked side-on x-ray slit images. Shock wave transition through the foam is detected via streaked optical self-emission from foil attached on the foam rear side. The shock transition time increases with the pore size, foam density, and also with the contents of high Z additions in plastic foams. Foil acceleration is observed via 3-frame interferometry. Comparison of experimental results with numerical simulations and an analytical model is underway.