gebhart/patrepeval huggingface dataset:
Enterovirus71 virus-like particles produced from insect cells and purified by multistep chromatography elicit strong humoral immune responses in mice (2015)

This work presents a novel multistep chromatographic technique, an effective way of purifying EV71 VLPs with high purity. This purification process can thus serve as foundation for further development of industrial-scale production process of EV71 VLP vaccine candidates.
Ehlers-Danlos syndrome presenting as rheumatic manifestations in the child. (1981)

Nine patients with Ehlers-Danlos syndrome (EDS) presented with joint complaints. This represented 5% of the new pediatric arthritis patients seen over a 6-month period. All 9 patients had a history of double-jointedness, and 7 had arthralgias associated with increased physical activity. On physical examination all had hypermobile joints, 7 had joint tenderness, but none had joint swelling. Based on the presence of other features including hyperextensible skin, widened scars, and cardiac clicks and murmurs, 8 were categorized as EDS Type II and 1 as EDS Type III. It posed a significant problem because the diagnosis had not been previously entertained before consultation and erroneous diagnosis had been made. Therefore, EDS should be included in the differential diagnosis of polyarthralgia in the child.
Supplementary Figure 1 from Antitumoral Activity of Lenalidomide in <i>In Vitro</i> and <i>In Vivo</i> Models of Mantle Cell Lymphoma Involves the Destabilization of Cyclin D1/p27<sup>KIP1</sup> Complexes (2023)

&lt;p&gt;PDF file - 1473K, Recounting of cells with nuclear positivity for cyclin D1 and p27KIP1 in (A) tumor specimen from two MCL patients presenting with a classical (Pt#1) or a blastoid (Pt#3)subtype and (B) in 6 MCL cell lines from either high (Rec-1, JBR and ZBR) or low (JVM-2, Jeko-1 and ZBR) expression profile.&lt;/p&gt;
Partial response signaling for improved chromatic dispersion tolerance in intensity modulation optical transmissions (2018)

We investigate partial response signaling (PRS) as a way of increasing the transmission length achievable by direct detection optical systems. The performance of the duobinary and PRS modulations is evaluated against that of conventional on-off-keying (OOK). We prove by simulation and experimentally that duobinary increases the link distance by up to 1.5 times and PRS by up to 3 times, when no signal processing is employed. The gain is preserved even when equalization is used. PRS is employed also with 4-level pulse-amplitude modulation (PAM-4) and is shown to improve the transmission distance by almost 3 times.
[Phenytoin induced agranulocytosis: direct and T cell-mediated mechanisms]. (1990)

A 57-year-old male was admitted to our hospital because of high fever and dyspnea. He had convulsive attacks after the operation for subarachnoid hemorrhage. He received an anticonvulsant, Hydantol F (Phenytoin + Phenobarbital), for 20 days before hospitalization. The white cell count on admission was 900/microliters without any neutrophils. Pseudomonas was demonstrated from blood cultures. After the anticonvulsant was discontinued and potent antibiotics were administered, his symptoms improved. Neutrophils appeared in the peripheral blood. We investigated the effect of phenytoin on the granuloid precursors using in vitro colony assay (CFU-C) after recovery from agranulocytosis. There was substantial decrease in CFU-C colony numbers when phenytoin or peripheral T-lymphocytes incubated with phenytoin was added in the culture. The addition of sera from acute phase did not affect the colony formation. These results suggested that direct toxic effect of the drug and cellular immunity played an important role in phenytoin induced agranulocytosis.
Experimental observation of nonspherically-decaying radiation from a rotating superluminal source (2004)

We describe the experimental implementation of a superluminal (i.e., faster than light in vacuo) polarization current distribution that both oscillates and undergoes centripetal acceleration. Theoretical treatments predict that the radiation emitted by each volume element of the superluminally moving distribution pattern will comprise a Čerenkov-like envelope with two sheets that meet along a cusp. Correspondingly, the emission from the experimental machine is found to be tightly beamed in both the azimuthal and polar directions. The beaming is frequency independent and has a sharply defined and unchanging geometry determined only by the speed and path of the moving distribution pattern, i.e., by the parameters governing the structure of the Čerenkov-like envelopes. In addition, over a restricted range of angles, we detect the presence of cusps in the emitted radiation. These, which are due to the focusing of wave fronts on a propagating space curve, result in the reception, during a short time period, of radiation emitted over a considerably longer period of (retarded) source time. The intensity of the radiation at these angles was observed to decline more slowly with increasing distance from the source than would the emission from a conventional antenna. The angular distribution of the emitted radiation and the properties associated with the cusps are in good quantitative agreement with theoretical models of superluminal sources once the effect of reflections from the earth’s surface are taken into account. In particular, the prediction that the beaming and the slow decay should extend into the far zone has been tested to several hundred Fresnel distances (Rayleigh ranges). The excellent agreement between the theoretical calculations and the data suggests that the apparatus achieves precise and reproducible control of the polarization current and that similar machines could be of general interest for studying and utilizing the novel effects associated with superluminal electrodynamics.
The Theory and Practice of Confucian Value of Integrity: The Brunei Case Study (2012)

Kothari (2010) speaks of executive greed, and here, the practitioners/academicians examine thoseleaders/managers who embrace and practice the value of integrity from the Confucian perspective in South EastAsia, more so, in the Brunei context. With inputs and feedback from various respondents and with the use ofChinese sayings and proverbs, the authors present and interpret the Confucian value of integrity. From Confuciuscomes the emphasis on leadership with integrity which is identified with positive, harmonious relationships aswell as the values of benevolence and reciprocity that bring many benefits to business prosperity. The practice ofConfucian teachings can bring much peace, learning, and growth for business sustainability.
ECG data compression by modelling of subbands (2002)

Some novel approaches to the compression of ECG signals, based on filter banks and transforms used in conjunction with parametric signal modelling are proposed. Quite recently the use of ARMA models for representing the transform coefficients obtained by applying large size discrete cosine transforms (DCT) to ECG signals has been examined (see B. Madhukar and I.S.N. Murthy, Computers and Biomedical Research, vol.26, p.310-17, 1993). The authors extend and generalize the ideas put forward by Madhukar and Murthy by: (1) Allowing the algorithm to work on arbitrary ECG signals-thus not making any assumptions about the suitability of the ECG signal to be split into so called beat-synchronous frames; (2) By viewing the DCT as a member of the class of perfect reconstruction filter banks the authors examine alternative transforms/filter banks, and finally; (3) The authors propose a scheme for selecting an optimum filter bank/transform in the proposed coding scheme. It is concluded, somewhat surprisingly, that the DCT outperforms the more common filter bank choices known from the subband coding literature. However, the authors find that optimizing the transform, rather than just selecting the DCT, gives rise to improved coding performance.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Vingt-cinq ans d'actions concertées françaises sur les écoulements diphasiques (1998)

Gas-liquid or liquid-vapor two-phase flows are encountered in many imiustrial systems or processes, such as nuclear reactors, rocket cryogenie engines. chemical contactors, oil wells, pipe-lines. evaporators or condensers. Offers for research and development by the French laboratories are exemplified in this paper. Cooperative research programs have been carried out in France for more than twenty-five years and have led to a network of /{rench laboratories which are now internationally recagnized. They have also allawed technolagy ressources ta be transferred fram basic research to industrial applications.
Small, Hard Macular Drusen and Peripheral Drusen: Associations with AMD Genotypes in the Inter99 Eye Study (2010)

In this study, the presence of 20 or more small, hard macular drusen per eye was not associated with known AMD-related polymorphisms, whereas the study confirmed an association of peripheral drusen with CFHY402H. (ClinicalTrials.gov number, NCT00289237).
Static and Dynamic Debugging of Modelica Models (2012)

The high abstraction level of equation-based objectoriented languages (EOO) such as Modelica has the drawback that programming and modeling errors are often hard to find. In this paper we present static and dynamic debugging methods for Modelica models and a debugger prototype that addresses several of those problems. The goal is an integrated debugging framework that combines classical debugging techniques with special techniques for equation-based languages partly based on graph visualization and interaction.
Characterization of RhoA-binding Kinase ROKα Implication of the Pleckstrin Homology Domain in ROKα Function Using Region-specific Antibodies (2002)

Rho-binding kinase alpha (ROKalpha) is a serine/threonine kinase with multiple functional domains involved in actomyosin assembly. It has previously been documented that the C terminus part of ROKalpha interacts with the N-terminal kinase domain and thereby regulates its catalytic activity. Here we used antibodies against different domains of ROKalpha and were able to reveal some structural aspects that are essential for the specific functions of ROKalpha. Antibodies against the kinase domain revealed that this part of the protein is highly complex and inaccessible. Further experiments confirmed that this domain could undergo inter- and intramolecular interactions in a complex manner, which regulates the kinase catalytic activity. Other antibodies that raised against the coiled-coil domain, Rho binding domain, and the pleckstrin homology (PH) domain were all effective in recognizing the native proteins in an immunoprecipitation assay. Only the anti-Rho binding domain antibodies could activate the kinase independent of RhoA. The PH antibodies had no apparent effects on the catalytic activity but were effective in blocking actomyosin assembly and cell contractility. Likewise, mutations of the PH domains can abrogate its dominant negative effects on actin morphology. The subsequent disruption of endogenous ROK localization to the actomyosin network by overexpressing the PH domain is supportive of a role of the PH domain of ROK in targeting the kinase to these structures.
Seasonal variation of kaurane-type diterpenes and cinnamic acid derivatives in leaves of Mikania laevigata and Mikania glomerata cultivated under different shading conditions (2011)

Mikania glomerata Spreng. and Mikania laevigata Sch.Bip. ex Baker are medicinal plants popularly named 'guaco', whose leaves are used to treat respiratory diseases, with coumarin (1) and kaurane-type diterpenes regarded as the bioactive constituents. The goal of the study was to undertake seasonal studies on the contents of chemical markers in leaves under different shading conditions. Species were cultivated under different levels of solar radiation and full sunlight. The leaves were collected in the middle of each season year.The contents of 1, o-coumaric (2), benzoylgrandifloric (3), cinnamoylgrandifloric (4) and kaurenoic (5) acids were quantified in dried leaves of both species by RP-HPLC [1].Significant differences were found in the contents of cinnamic acid derivatives (1 and 2) and kaurane-type diterpenes (3, 4 and 5) for the evaluated harvesting periods and cultivation environments. o-Coumaric acid was solely detected in M. laevigata in concentrations bellow the limit of quantification (<0,045%), in plants under 80% shading, collected in the autumn. Both 1 and 2 were not detected in the analyzed samples of M. glomerata.The average concentration of coumarin reached its maximum (0.94%) in the summer, in plants growing under 80% shading.In general, both species presented higher amounts of the kaurane-type diterpenes in plants cultivated under sunlight, except for 3 in M. glomerata. Altogether, the obtained results point out that the highest content of coumarin is reached in M. laevigata cultivated under 80% shading, preferentially harvested in the summer, but with reduced levels of kaurane-type diterpenes.On the other hand, M. glomerata shall be cultivated under full sunlight for maximum contents of the kaurane-type diterpenes.
A Thermal Decarbonylation of Penam β-Lactams (2008)

Penam acids 6-8 [i.e., (2S,5R,6R)-, (2S,5S,6R)-, and (2S,5R,6S)-isomers of 6-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid] were prepared by deesterification of the corresponding methyl esters 2-4. The same methodology applied to ester 1 did not lead to the (2S,5S,6S)-isomer 5 but rather a 72% yield of the thiazoline derivative 9. High-resolution mass spectrometry analysis of the reaction headspace gases indicated that a stoichiometric amount of carbon monoxide is produced during the deesterification of 1. A mechanism for this decarbonylation reaction is proposed. This appears to represent a new type of fragmentation reaction for a penam carboxylic acid. The free energies of various reaction species along viable decarbonylation reaction coordinates for acids 5 and 7 were computed by using the density functional theory method IEFPCM/M06/6-31+G(d). Anionic and zwitterionic (neutral) variants of the proposed mechanism were considered, but each produced computed activation free energies deemed to be too high (>45 kcal/mol) to be experimentally relevant. The computed activation free energies for the protonated (cationic) variant of the mechanism were 17.3 kcal/mol for 7 vs 8.8 kcal/mol for 5. The value of this difference in energies of activation (DeltaDeltaG++) is quite consistent with experimental observations and supports the proposed mechanism. For a portion of the computed reaction coordinate that involves ring opening of the lactam ring by an internal carboxylic acid group to form a cyclic anhydride, the expected tetrahedral intermediate was circumvented by a direct (concerted) and facile N- to O-acyl migration event. Additional thermal gas-phase reaction products produced during gas chromatographic analysis of the penams 1-8 were characterized with high-resolution mass spectrometry, and possible mechanisms for their formation are presented.
SHREC&#x2019;08 entry: Shape based face recognition with a Morphable Model (2008)

We present a method for face recognition by fitting a 3D Morphable Model to shape data. Fitting is done with a a robust nonrigid ICP algorithm. For recognition, it is possible to use either the fitted model parameters, or the correspondences induced by the model. We compare different similarity measures, and show that a 3D Morphable Model allows very robust retrieval results.
Data warehousing: dealing with the growing pains (2002)

A data warehouse provides a customer with information to run and plan their business. It is true that if the data warehouse cannot quickly adapt to changes in the environment then the company will lose the advantage that information provides. A warehouse must be built with a solid foundation that is flexible and responsive to business changes. The purpose of the paper is to share experiences in the area of managing the growth within the data warehouse. There are many technical issues that need to be addressed as the data warehouse grows in multiple dimensions. The ideas in this paper should enable you to provide the correct foundation for a long term warehouse. Very few companies are discussing these issues and the lack of discussion leads to a lack of knowledge that will further lead to poor architectural choices. The paper articulates not only the benefits that are derived from data warehousing today but how to prepare to reap benefits for many tomorrow's. It also explores the questions to ask, the points to make, and the issues to be addressed to have a long term successful data warehouse project.
Let’s Unleash the Network Judgment: A Self-Supervised Approach for Cloud Image Analysis (2023)

Abstract Accurate cloud type identification and coverage analysis are crucial in understanding the Earth’s radiative budget. Traditional computer vision methods rely on low-level visual features of clouds for estimating cloud coverage or sky conditions. Several handcrafted approaches have been proposed; however, scope for improvement still exists. Newer deep neural networks (DNNs) have demonstrated superior performance for cloud segmentation and categorization. These methods, however, need expert engineering intervention in the preprocessing steps—in the traditional methods—or human assistance in assigning cloud or clear sky labels to a pixel for training DNNs. Such human mediation imposes considerable time and labor costs. We present the application of a new self-supervised learning approach to autonomously extract relevant features from sky images captured by ground-based cameras, for the classification and segmentation of clouds. We evaluate a joint embedding architecture that uses self-knowledge distillation plus regularization. We use two datasets to demonstrate the network’s ability to classify and segment sky images—one with ∼ 85,000 images collected from our ground-based camera and another with 400 labeled images from the WSISEG database. We find that this approach can discriminate full-sky images based on cloud coverage, diurnal variation, and cloud base height. Furthermore, it semantically segments the cloud areas without labels. The approach shows competitive performance in all tested tasks, suggesting a new alternative for cloud characterization.
Remote and Autonomous Measurements of Precipitation for the Northwest Ross Ice Shelf, Antarctica (2021)

Abstract. The Antarctic Precipitation System project deployed and maintained four sites across the northwest Ross Ice Shelf in Antarctica from November 2017 to November 2019. The goals for the project included the collection of in situ observations of precipitation in Antarctica spanning a duration of two years, an improvement in the understanding of precipitation events across the Ross Ice Shelf, and the ability to validate precipitation data from atmospheric numerical models. At each of the four sites the precipitation was measured with an OTT Pluvio2 precipitation gauge. Additionally, snow accumulation at the site was measured with a sonic ranging sensor and using GPS-Interferometry Reflectivity. Supplemental observations of temperature, wind speed, particle count, particle size and speed, and images and video from a camera, were collected to provide context to the precipitation measurements. The collected dataset represents some of the first year-round observations of precipitation in Antarctic at remote locations using an autonomous measurement system. The acquired observations have been quality controlled, post-processed, and are available for retrieval through the United States Antarctic Program Data Center (Seefeldt, 2021; doi.org/10.15784/601441).
Mixed control of boundary migration and the principle of microstructural evolution (2016)

This paper describes a new mechanism for boundary migration, namely the mixed control mechanism (either diffusion or interface reaction), and the principle of microstructural evolution in polycrystals. The basis of the mechanism and the microstructural prediction of the principle are explained, including key experimental results that support the mechanism and the principle. The solid state single crystal growth method, a new technique of single crystal fabrication, is described as an application example of the microstructural evolution principle. Future research directions in the subject areas are also given.
On computing restricted projections of representative instances (1985)

Article On computing restricted projections of representative instances Share on Author: Yehoshua Sagiv View Profile Authors Info & Claims PODS '85: Proceedings of the fourth ACM SIGACT-SIGMOD symposium on Principles of database systemsMarch 1985 Pages 171–180https://doi.org/10.1145/325405.325427Online:25 March 1985Publication History 24citation82DownloadsMetricsTotal Citations24Total Downloads82Last 12 Months2Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Concentric Sphere Mie Theory Model: Applications to Nanoshell Spectra Prediction and Design of Anti-Reflection Coatings for Optical Traps (2008)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Y. Hu, T. A. Nieminen, L. R. Bickford, and R. A. Drezek, "Concentric Sphere Mie Theory Model: Applications to Nanoshell Spectra Prediction and Design of Anti-Reflection Coatings for Optical Traps," in Biomedical Optics, OSA Technical Digest (CD) (Optica Publishing Group, 2008), paper BTuF12. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
The ideal crystal for structural biology (2021)

The ideal crystal for structural biology can be defined as one that diffracts to sufficient resolution and completeness to answer the biological question being asked. While simply stated, that question can be asked in many ways and there is no single ideal. Single crystal studies can be used to build up a static picture of the structure from a synchrotron or laboratory source, serial crystallography can be used for those systems that may be radiation or timesensitive. For work with X-ray free-electron lasers, crystals measured in terms of the number of unit cells may provide useful data. The ideal crystals span two extremes, macrocrystals for neutron studies probing hydrogens or charge state, and nanocrystals for electron diffraction where ideal crystal dimensions are measured in hundreds of nanometers. This talk discusses the crystallization experiment and how the first crystallization outcomes can be tailored to achieve the ideal outcome for the technique used for the final analysis. The knowledge of the behavior of proteins and their phase diagrams, and how different experimental conditions and techniques modulate nucleation and growth phases, are essential to optimize crystal size without expending on crystal quality. Our current knowledge is vast and distilling it to a set of useable and workable concepts is imperative given the expansion of techniques requiring appropriate crystals and the divergent requirements.