gebhart/patrepeval huggingface dataset:
Spatial analysis of digital technologies and impact on socio - cultural values in selected communities in Nigeria (2016)

The objective of this study was to determine the spatial distribution of digital technologies and ascertain whether digital technologies have significant impact on socio - cultural values or not. Moran’s index and Getis and Ord’s statistic were used for cluster and hotspots analysis. The unique locations of digital technologies were investigated through standard deviational ellipse and standard distance deviation, while, the Chi-square statistic was used for test of significance. The Nigerian 2008 Demographic Household Survey report on counts of households with television and land phone was used. Through systematic sampling, 200 households were investigated within 10 wards in Mopamuro Local Government Area (LGA) of Kogi State, Nigeria. Questionnaires were administered to identify households with television and mobile phone and the impact on socio - cultural values: communal gatherings/meetings, local songs and farming. For television, there was 5-10 % likelihood that the clustered pattern could be a result of random chance. No apparent clustering was detected at this scale for land phone. The concentration of televisions and mobile phones across all communities in Mopamuro LGA was high. At 5% level of significance, results showed that the advent of digital technologies have significant impact on socio - cultural values. The study reveals strong spatial dependence of households with television and mobile phone in Nigeria. The findings should enable the orientation of social transformation programmes geared towards preserving socio - cultural values through digital technologies. Keywords : Digital technology, hypotheses tests, impact, socio - cultural values, spatial analysis
Complete Genome Sequences of Four Serotypes of Dengue Virus Prototype Continuously Maintained in the Laboratory (2019)

Dengue prototype strains are widely used for virological study. The strains presented here have been cultured under different laboratory environments, resulting in accumulating genetic variations. We present the genomes of four serotypes of the dengue prototype strain that were continuously maintained in the laboratory. These genomes contain bases different from those of the original prototype strains in GenBank.
Measurement of Localized Current Distribution Applied to a Vanadium Redox Flow Battery (2013)

Abstract not Available.
Additive effects of inhaled nitric oxide and intravenous milrinone in experimental pulmonary hypertension (2000)

Milrinone and INO both decrease pulmonary hypertension individually, and the combination produces additive effects. Combination therapy may produce potent and selective pulmonary vasodilation during the treatment of pulmonary hypertension.
Real-life safety and efficacy of omalizumab in Japanese patients with severe allergic asthma who were subjected to dosing table revision or expansion: A post-marketing surveillance (2020)

The findings from this study support the safety and efficacy of omalizumab administered based on the revised and expanded dosing table in Japanese patients with severe allergic asthma.
A blueprint for introducing disruptive technology into the Internet (2003)

This paper argues that a new class of geographically distributed network services is emerging, and that the most effective way to design, evaluate, and deploy these services is by using an overlay-based testbed. Unlike conventional network testbeds, however, we advocate an approach that supports both researchers that want to develop new services, and clients that want to use them. This dual use, in turn, suggests four design principles that are not widely supported in existing testbeds: services should be able to run continuously and access a slice of the overlay's resources, control over resources should be distributed, overlay management services should be unbundled and run in their own slices, and APIs should be designed to promote application development. We believe a testbed that supports these design principles will facilitate the emergence of a new service-oriented network architecture . Towards this end, the paper also briefly describes PlanetLab, an overlay network being designed with these four principles in mind.
Supplementary Table S2 from Isolation and Molecular Profiling of Bone Marrow Micrometastases Identifies <i>TWIST1</i> as a Marker of Early Tumor Relapse in Breast Cancer Patients (2023)

Supplementary Table S2 from Isolation and Molecular Profiling of Bone Marrow Micrometastases Identifies &lt;i&gt;TWIST1&lt;/i&gt; as a Marker of Early Tumor Relapse in Breast Cancer Patients
Synthesis of 3-substituted furans and the formation of 3-(4,8,12-tri-methyltridecyl)furan (1973)

3-(4,8,12-Trimethyltridecyl)furan (I) was isolated from cigarette smoke condensate and its structure was confirmed by synthesis. During attempts at synthesis, two general routes to 3-substituted furans were investigated. In the first, greatly improved procedures for the preparation of 3-furoic acid were devised; the second involved thermal cyclisation and dehydration of 1,2,3,4-tetraols.
Lowering of Electrostatic Actuator Driving Voltage and Increasing Generated Force Using Spontaneous Polarization of Ferroelectric Nematic Liquid Crystals (Adv. Phys. Res. 1/2022) (2022)

Mode Division Multiplexing In article number 202200017, Suzushi Nishimura and co-workers show ferroelectric nematic liquid crystals that can be used as electrostatic actuator media. The ferroelectric material's spontaneous polarization drastically increases the electrostatic actuator's generated force by a factor of 1000, which also shows a linear response to the applied voltage. When a double-helical coil electrode device fabricated by rapid prototyping with a 3D printer is filled with this material, the actuator operates at several tens of volts. The potential exists for a low-voltage, high-power, and lightweight actuator with a simple structure, which may find applications in the near future as an artificial muscle that helps people to stand and walk or as an actuator that does not use rare metals.
ForceField ofOrganicLiquids: Density, of Vaporization, Heat Capacities, Surface Tension, Isothermal Com- pressibility, Volumetric Expansion Coefficient, and Dielectric Constant (2012)

The chemical composition of small organic molecules is often very similar to amino acid side chains or the bases in nucleicacids,andhencethereisnoapriorireasonwhyamolecularmechanicsforce fieldcouldnotdescribebothorganicliquidsand biomolecules with a single parameter set. Here, we devise a benchmark for force fields in order to test the ability of existing force fieldstoreproducesomekeypropertiesoforganicliquids,namely,thedensity,enthalpyofvaporization,thesurfacetension,theheat capacity at constant volume and pressure, the isothermal compressibility, the volumetric expansion coefficient, and the static dielectric constant. Well over 1200 experimental measurements were used for comparison to the simulations of 146 organic liquids. Novelpolynomialinterpolationsofthedielectricconstant(32molecules),heatcapacityatconstantpressure(threemolecules),and theisothermalcompressibility(53molecules)asafunctionofthetemperaturehavebeenmade,basedonexperimentaldata,inorder tobeabletocomparesimulationresultstothem.Tocomputetheheatcapacities,weappliedthetwophasethermodynamicsmethod (Lin et al. J. Chem. Phys. 2003, 119, 11792), which allows one to compute thermodynamic properties on the basis of the density of states as derived from the velocity autocorrelation function. The method is implemented in a new utility within the GROMACS molecular simulation package, named g_dos, and a detailed exposof the underlying equations is presented. The purpose of this workistoestablishthestateoftheartoftwopopularforce fields,OPLS/AA(all-atomoptimizedpotentialforliquidsimulation)and GAFF (generalized Amber force field), to find common bottlenecks, i.e., particularly difficult molecules, and to serve as a reference point for future force field development. To make for a fair playing field, all molecules were evaluated with the same parameter settings, such as thermostats and barostats, treatment of electrostatic interactions, and system size (1000 molecules). The densities and enthalpy of vaporization from an independent data set based on simulations using the CHARMM General Force Field (CGenFF)presentedbyVanommeslaegheetal.(J.Comput.Chem.2010,31,671)areincludedforcomparison.We findthat,overall, the OPLS/AA force field performs somewhat better than GAFF, but there are significant issues with reproduction of the surface tension and dielectric constants for both force fields.
Supplementary Methods and Materials, Figure Legends 1-4 from Inhibition of Multiple Vascular Endothelial Growth Factor Receptors (VEGFR) Blocks Lymph Node Metastases but Inhibition of VEGFR-2 Is Sufficient to Sensitize Tumor Cells to Platinum-Based Chemotherapeutics (2023)

Supplementary Methods and Materials, Figure Legends 1-4 from Inhibition of Multiple Vascular Endothelial Growth Factor Receptors (VEGFR) Blocks Lymph Node Metastases but Inhibition of VEGFR-2 Is Sufficient to Sensitize Tumor Cells to Platinum-Based Chemotherapeutics
Stator current based indicators for bearing fault detection in synchronous machine by statistical frequency selection (2011)

The aim of this paper is to present some indicators developed for efficient detection of bearing defaults in high speed synchronous machines using a stator current analysis. These actuators are used in an air conditioning fan for aeronautic applications. The signatures of the bearing defects appear through an increase in amplitude of specific current harmonics multiples of the rotation frequency. From an experimental comparison between a healthy fan and another with damaged bearings, an automatic frequency selection is performed to identify the frequency ranges for which the energy is the most sensitive to the considered faults. From these frequencies, several strategies are investigated to propose a suitable indicator for the bearing fault detection. A post-processing algorithm is then developed and tested for different measurements, different types of faults and different operating points, to ensure the robustness of the proposed method.
A modified CUT&RUN-seq technique for qPCR analysis of chromatin-protein interactions (2022)

Chromatin immunoprecipitation coupled with quantitative PCR (ChIP-qPCR) even with optimization may give low signal-to-background ratio and spatial resolution. Here, we adapted Cleavage Under Targets and Release Using Nuclease (CUT&RUN) (originally developed by the Henikoff group) to develop CUT&RUN-qPCR. By studying the recruitment of selected proteins (but amenable to other proteins), we find that CUT&RUN-qPCR is more sensitive and gives better spatial resolution than ChIP-qPCR. For complete details on the use and execution of this protocol, please refer to Skene et al. (2018) and Skene and Henikoff (2017).
Immunologic memory in Haemophilus influenzae type b conjugate vaccine failure (2003)

Higher antibody responses to invasive Hib disease in vaccinated children with meningitis reflect priming for immunologic memory by the vaccine. Although a majority of children in the UK are protected from Hib disease by immunisation, the relative roles of immunologic memory and other immune mechanisms in conferring protection remain unclear.
Carbon Nanotubes in Electron Donor−Acceptor Nanocomposites (2005)

This Account presents recent advances in the design, synthesis, characterization, and potential applications of new hybrid materials based on carbon nanotube and electron donors. Fast charge separation and slow charge recombination are consistently observed in a variety of composites that contain porphyrin derivatives. The ultimate goal of using these systems to prepare practical photoelectrochemical devices is discussed, and a cell with a monochromatic efficiency of 8.5% conversion of light into current is illustrated.
KeyGenes, a Tool to Probe Tissue Differentiation Using a Human Fetal Transcriptional Atlas (2015)

Differentiated derivatives of human pluripotent stem cells in culture are generally phenotypically immature compared to their adult counterparts. Their identity is often difficult to determine with certainty because little is known about their human fetal equivalents in vivo. Cellular identity and signaling pathways directing differentiation are usually determined by extrapolating information from either human adult tissue or model organisms, assuming conservation with humans. To resolve this, we generated a collection of human fetal transcriptional profiles at different developmental stages. Moreover, we developed an algorithm, KeyGenes, which uses this dataset to quantify the extent to which next-generation sequencing or microarray data resemble specific cell or tissue types in the human fetus. Using KeyGenes combined with the human fetal atlas, we identified multiple cell and tissue samples unambiguously on a limited set of features. We thus provide a flexible and expandable platform to monitor and evaluate the efficiency of differentiation in vitro.
The Interferon-γ Receptor: A Comparison with Other Cytokine Receptors (1990)

During the past few years, identification of cytokine receptors has become a major goal in cytokine research. A great deal has been learned from the plethora of receptor structures that have been elucidated recently. Although, evidently, the complexity of the cytokine network extends to the signaling pathways involved, some of these pathways have now become more accessible. The challenge in the coming years will be to fill the gap between the receptors and the gene regulatory events induced by the various cytokines. Another challenge lies in the potential use of cytokine receptors as targets for modulating cytokine action. Since the topic of interferon (IFN) receptors has been reviewed recently, this minireview will focus on the current knowledge on the IFN-gamma receptor in the context of recent advances on other cytokine receptors. Some new receptor models that may be of consequence for characterizing IFN receptors will be presented briefly.
Classification of Short Text Comments by Sentiment and Actionability for VoiceYourView (2010)

Much has been documented in the literature on sentiment analysis and document summarisation. Much of this applies to long structured text in the form of documents and blog posts. With a shift in social media towards short commentary (see Facebook status updates and twitter tweets), the difference in comment structure may affect the accuracy of sentiment analysis techniques. From our VoiceYourView trial, we collected over 2000 individual short comments on the topic of library refurbishment, many of which are transcribed spoken comments. We have shown success in determining the theme of comments by looking for the first noun and using a semantic tag set to categorise this noun and hence the comment for short comments. Sentiment is a measure of how positive or negative a comment is, and the actionability metric is a measure of how actionable the comment is, i.e. how useful it is. This paper looks towards applying methods from the literature to our dataset with the aim of evaluating methods of automatic sentiment and actionability analysis for our VoiceyourView application data and has relevance to data from other applications, e.g. those from the social media. With many social media commentary applications moving to add speech platforms, VoiceYourView data may be representative of the type of free-form spoken text input to be expected in such platforms.
Manipulating Oxidative Stress Following Ionizing Radiation (2020)

It is now well accepted that the ionizing radiationgenerated reactive oxygen species (ROS), that constitute ~2/3 of the effects of external beam radiation, do not only produce direct tumor cell death, but also affect the surrounding microenvironment.
The cellular interactions of laminin fragments. Cell adhesion correlates with two fragment-specific high affinity binding sites. (1987)

The molecular interactions of laminin with several tumor cell lines and skin fibroblasts were investigated by radioligand binding studies and cell attachment assays using laminin, the laminin-nidogen complex, and laminin fragments as substrates and also domain-specific antibodies as inhibitors of cell attachment. The majority of cells showed a dual binding pattern for fragments 1 and 8 which originate from short-arm or long-arm structures of laminin, respectively. Both of these fragments in solution bind to suspended cells with high affinity (KD = 1-10 nM), with the receptor numbers for each fragment depending on the cell type. Competition studies and independent variation of receptor numbers demonstrated that the cell-binding structures on each fragment are different, implicating the existence of two distinct cellular receptors for laminin. The ability of these fragments to act as substrates for cell adhesion correlated with the presence of high affinity binding sites on the cells. However, only antibodies to fragment 8 were able to block cell adhesion to laminin, despite the presence of binding sites for fragment 1. A few cells had very low numbers of high affinity receptors for either fragment 1 or 8. The latter cell type was used to demonstrate that complex formation between laminin and nidogen, which binds to fragment 1 structures, reduces the potential of laminin for cell binding.
Uptake and clearance analysis of Technetium 99m labelled iron oxide nanoparticles in a rabbit brain (2015)

Nanoparticles as solid colloidal particles are extensively studied and used as anticancer drug delivery agents because of their physical properties. This current research aims to prepare water base suspension of uncoated iron oxide nanoparticles and their biodistribution study to different organs, especially the brain, by using a single photon emission computed tomography gamma camera. The water-based suspension of iron oxide nanoparticles was synthesised by a reformed version of the co-precipitation method and labelled with Tc99m for intravenous injection. The nanoparticles were injected without surface modification. X-ray diffraction (XRD), energy dispersive spectrometry (EDS) and transmission electron microscope (TEM) techniques were used for characterisation. Peaks of XRD and EDS indicate that the particles are magnetite and exist in aqueous suspension. The average diameter of iron oxide nanoparticles without any surface coating determined by TEM is 10 nm. These particles are capable of evading the reticuloendothelial system and can cross the blood-brain barrier in the rabbit. The labelling efficiency of iron oxide nanoparticles labelled with Tc99m is 85%, which is good for the biodistribution study. The sufficient amount of iron oxide nanoparticles concentration in the brain as compared with the surrounding soft tissues and their long blood retention time indicates that the water-based suspension of iron oxide nanoparticles may be an option for drug delivery into the brain.
Cardiac pathology exceeds skeletal muscle pathology in two cases of limb‐girdle muscular dystrophy type 2I (2009)

Limb-girdle muscular dystrophy type 2I (LGMD-2I) is caused by mutations in the fukutin-related protein gene (FKRP) that lead to abnormal glycosylation of alpha-dystroglycan in skeletal muscle. Heart involvement in LGMD-2I is common, but little is known about a underlying cardiac pathology. Herein we describe two patients with LGMD-2I (homozygous FKRP mutation c.826C>A, p.Leu276Ile) who developed severe congestive heart failure that required cardiac transplantation. The dystrophic pathology and impairment of alpha-dystroglycan glycosylation were severe in the heart but mild in skeletal muscle, underscoring the lack of correlation between cardiac and skeletal muscle involvement in some LGMD-2I patients.
A maturing understanding of naive T cells (2015)

In this issue of Blood , Cieri et al and Roberto et al report that recovery of a diverse T-cell receptor (TCR) repertoire following haploidentical hematopoietic stem cell transplantation (haplo-HSCT) using posttransplant cyclophosphamide (pt-Cy) is dependent on T memory stem cells (T SCM ) maturing from naive T cells adoptively transferred in the donor graft. 1,2
Tensile-bending Leveller and Its Problems in Application (2005)

The working principle and characteristics of the tensile and bending leveller are introduced. The problems in production such as amount of draught of the bend rolls, glide of steel strip on the bridle rolls, lose of the elongation and so on are analyzed and optimized.
No-Snapback LDMOS Using Adaptive RESURF and Hybrid Source for Ideal SOA (2021)

A simple modification to the lateral DMOS is demonstrated, enabling a significant extension to the electrical safe operating region. This approach uses a novel Hybrid Source to suppress the parasitic bipolar, prevent snapback and enable operation at high drain voltage &amp; current regions that have traditionally been inaccessible due to triggering of the parasitic bipolar. Trigger currents exceeding 10x that of conventional PN source devices under grounded gate, very fast TLP conditions have been achieved. This improvement does not compromise the basic DC parameters, such as specific on-resistance or breakdown voltage. This paper covers the device architecture, formation of the Hybrid Source, electrical performance, TCAD simulation and discussion of the mechanisms behind this new device and the improvements it enables.
Stability of a Queueing System with Concurrent Service and Locking (1987)

Resource sharing systems, such as database management systems, utilize various types of locking to maintain consistency. Most locking mechanisms cause some resources to remain idle at certain times when there is work for them to do, inducing a decrease in the system’s capacity. This decrease of capacity is reflected in the stability condition for the locking system as compared to the system without locking. We consider the following locking system. There are N servers operating in parallel and two types of incoming customers. The first type corresponds to simple customers, i.e., customers with no locking requirements, and the second corresponds to customers that have to be processed simultaneously by all N servers. When a server is ready to serve such a customer, it has to wait until all servers are ready to serve that same customer. We determine a necessary and sufficient condition for stability of this system, which can be expressed in terms of the mean of the maximum of N random variables, each representing the amount of work due to simple customers arriving at a station between successive locking customers. For a particular case we provide an asymptotic analysis which indicates that the wasted capacity in such a system grows as $\log N$.
Salt-assisted pyrolysis of covalent organic frameworks to porous heteroatom-doped carbons for supercapacitive energy storage (2019)

Highly porous heteroatom-doped carbons with ultra-high supercapacitive performance are prepared by salt-assisted pyrolysis of covalent organic frameworks.