gebhart/patrepeval huggingface dataset:
Simulation of Magnetoelastic Interactions in Polycrystalline Ferromagnetic Material. (1999)

Simple numerical model is developed to simulate magnetoelastic interactions in polycrystalline steel. Elastic properties and magnetic properties of ferromagnetic steel are related to each other, both of which depend on the magnetic domain structure. In the demagnetized state, six types of domains, each of which is magnetized parallel to one of the crystallographic axes, are randomly distributed in individual grain. The magnetic field increases the volume of the domains magnetized parallel to the field at the sacrifice of the other domains. When the domain realignment is almost completed, the domain magnetization starts to rotate. The stress also expands the domains parallel to the tension or perpendicular to the compression. In this study, we propose the simulation model which considers the volume change of the domains and the rotation magnetization, both induced by the magnetic field and the stress. The stress dependences of permeability and magnetostriction are predicted. Comparison of the results with the experiments ensures that the model is useful in explaining the experimental results.
Interim results of a phase 1b/2a study evaluating the nano pharmaceutical CRLX101 with bevacizumab (bev) in the treatment of patients (pts) with refractory metastatic renal cell carcinoma (mRCC). (2014)

412 Background: VHL is inactivated in most clear cell RCC (ccRCC) tumors giving rise to the HIF hypoxia response program and tumor angiogenesis. Antiangiogenic therapies are active in ccRCC, but resistance develops in all pts. Dual inhibition strategies may be needed to overcome resistance. CRLX101, a novel nano pharmaceutical formulation of camptothecin, has been shown in pre-clinical models to target HIF. We combined CRLX101 with bev in the treatment of pts with refractory mRCC in order to determine the safety and the recommended phase 2 dose (RP2D) of the combination, and to determine the therapeutic activity of treatment. Methods: Pts with mRCC refractory to conventional antiangiogenic therapies (all subtypes) were treated every 2 weeks with bev 10 mg/kg and escalating doses of CRLX101 (12 mg/m 2 , 15 mg/m 2 ) in a standard 3+3 design with an expansion at the RP2D. Pts were treated until progression, death, or prohibitive toxicity. Adverse events were classified using CTCAE v 4.0. Radiographic results were assessed by RECIST v1.1. Results: 10 pts were enrolled on study – 6 clear cell, 2 papillary, 2 chromophobe. Median prior number of therapies was 2. No dose limiting toxicities were observed. CRLX101 at its single-agent RP2D (15 mg/m 2 ) was safely combined with standard bev. 2 episodes of grade 3 non-infectious cystitis and 1 episode of grade 3 hypertension were observed. All other toxicities were grade 1 or 2. The median progression free survival (PFS) was 7.6 months which exceeded our pre-specified threshold of 16 weeks and has triggered 2 nd stage accrual. 3 of 9 evaluable pts (33%) achieved a confirmed partial response (PR) including 1 patient with papillary mRCC; 4 pts (44%) displayed stable disease, and 2 had progressive disease as their best overall response. Conclusions: Our results demonstrate that CRLX101 can be safely combined with bev in pts with refractory mRCC. The RP2D is 15 mg/m 2 q2w of CRLX101 with standard bev. Preliminary outcomes to date suggest that clinical benefit, manifest as prolonged PFS, is conferred to pts with all histologic subtypes of mRCC. Clinical trial information: NCT01625936.
Environmental DNA (eDNA) COI metabarcoding Illumina MiSeq NGS PCR Protocol v1 (2018)

This protocol is aimed at amplifying the cytochrome c oxidase subunit I (COI) mitochondrial gene in eukaryotes. The primers (forward: mlCOIintF, reverse: HCO2198) utilized in this protocol are based on the primers utilized in Leray et al. 2013 (forward) and Folmer et al. 1994 (reverse). Amplicons generated using this protocol can then be sequenced using the Illumina platform. Primers used: Fluidigm CS1+mlCOIinfF Fluidigm CS2+HCO2198 Secondary COI PCR primers PE1-BC-CS1 PE2-BC-CS2
CHARACTERIZATION OF SPATIAL VARIATION IN HURRICANE SURGE (2018)

Planning, engineering, and development along surgeprone coasts rely on probabilistic surge hazard assessments. Over the last decade, U.S. agencies have implemented the joint probability method with optimal sampling (JPM-OS) (e.g., Resio et al. 2009) to overcome shortcomings in probabilistic estimates developed from the limited set of observed surges alone. Here, optimal sampling is used to reduce the number of high-fidelity surge simulations needed, given computational resource limitations. In current practice, hazard assessments with the JPM-OS use discrete storm simulations (order of 200 to 1000 storms), where each is assigned a probability mass (e.g., Toro et al. 2010), rather than defining surges for the continuum of probability densities. Such an approach introduces uncertainty because it does not fully capture the natural structure inherent in surge response (meteorological and larger-scale bathymetric effects) (Resio et al. 2017). On the other hand, physically based surge response functions (SRFs) that capture natural structure in the surge response provide an accurateâ€”0.2 to 0.5 m rootmean- square error depending on topographic and geographic complexityâ€”and efficient means for continuously defining probability densities (e.g., Taylor et al. 2015). But, application of SRFs in JPM-OS (JPMOS- SRF) has not been widely used in practice due a lack of systematic methods for spatial interpolation along complex shorelines and throughout the floodplain. Herein, we explore the use of spatially derived empirical orthogonal functions (EOFs) to overcome this spatial interpolation challenge.
Editorial: Wearable Sensor Technology for Monitoring Training Load and Health in the Athletic Population (2020)

No abstract available.
Frequency hopping multicarrier mMCSK modulation (2003)

Multicarrier modulation, and especially OFDM, has gained a wide interest due to the deployment of digital video broadcasting (DVB) and digital audio broadcasting (DAB). The main driver in commercial applications is the availability of high data rates with reasonable signal processing requirements. In some systems, pure OFDM signals, however, do not provide enough resistance to interference and hence multicarrier modulation has often been considered. We propose mMCSK signaling in conjunction with multicarrier modulation. The main point is to preserve a high data rate capability while enhancing interference resistance. We present the bit error rate analysis of the proposed scheme in an AWGN channel and consider the method in conjunction with a frequency hopping system.
Using mid-range RFID for location based activity recognition (2012)

Development of smarthome home application depends on the ability to identify resident activity and track occupancy of rooms as people move within a residence. Existing solutions to home activity recognition are evaluated using controlled experiments and having participants maintain logs of daily activities as ground truth. In our study, we evaluate the effectiveness of using mid-range RFID as a research tool to perform in-situ evaluation of smarthome systems. We propose that using bracelets and anklets embedded with passive RFID tags can provide an accurate ground truth system, which can help evaluate the performance of research solutions for smarthomes with higher accuracy - in presence of natural variability of people in activities and movement in homes.
Security in the Spring name service (2002)

Spring provides a uniform name service for an open ended collection of object types-in principle, any object, of any type, can be bound to any name. The name service implements authentication and access control to protect itself, and provides these same functions in an integrated way for the convenience of clients and the object managers that implement the various objects in the system. An object manager can delegate these functions to the name service, or implement its own policies. The name service is implemented as a collection of name servers which are generally autonomous and separate from each other and also from object managers. The architecture allows trusted and untrusted name servers and object managers to participate in providing naming and in publishing objects. Authentication is done at appropriate times to establish trust. These trust relationships are encoded in capability-like authenticated objects which are reused to avoid authentication complexity and overhead after trust is established.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Full-range, high-speed, high-resolution 1-µm spectral-domain optical coherence tomography using BM-scan for volumetric imaging of the human posterior eye (2008)

An alternative optical coherence tomography (OCT) to clinical ophthalmic 830 nm spectral-domain OCTs (SD-OCT) is demonstrated. An axial resolution of 7.4 microm, ranging depth of 4.2 mm in tissue, sensitivity of 98.5 dB, and detection speed of 38,300 axial scans/s have been achieved. These are comparable or superior to those of recently commercially available ophthalmic 830 nm SD-OCTs in clinics. In addition, fast volumetric imaging for the in vivo human posterior eye with high-contrast of the choroid is achieved. A broadband 1.04 microm light source enables the high-contrast and high resolution imaging of the retina and choroid. The ranging depth is extended by applying a full-range imaging method with an electro-optic modulator (BM-scan method). A prototype high-speed InGaAs line scan camera with 1024 pixels is used. A newly reported sensitivity improvement property of the BM-scan method demonstrates a sensitivity enhancement of 5.1 dB. We also introduce a newly developed resampling calibration method of spectrum that is independent of the intrinsic dispersion mismatch of the interferometer. The three-dimensional structure of the in vivo human optic nerve head with a very deep cupping is successfully visualized.
Elementary Pinning Force of Grain Boundaries in Supereonducting V3Ga Tapes (1986)

The elementary pinning force of grain boundaries was estimated for superconducting V 3 Ga tapes prepared by the surface diffusion method on pure and zirconium-doped vanadium tapes. It is 1.6-3.7×10 -4 N/m for pure vanadium tapes and 3.8-6.2×10 -4 N/m for zirconium-doped tapes. These values are much larger than the theoretical values by Zerweck, by Yetter et al. and by Welch based on the electron-scattering mechanism. Although Thuneberg's theory givesa value comparable to the observed results, it is incompatible with the observed increase in the elementary pinning force with the addition of zirconium.
Synthesis of L-glucurone. Conversion of D-glucose into L-glucose (1969)

L-Glucurone (2) was readily prepared on a small scale by treatment of D-glycero-D-gulo-heptono-lactone (1) with a molar equivalent of periodic acid; thin–layer chromatography was used for its isolation. On a larger scale pure crystalline L-glucurone was obtained in over 80% yield from 3,5;6,7-di-O-isopropylidene-D-glycero-D-gulo-heptonolactone (4) in two steps consisting of concomitant hydrolysis and oxidation of 4 with periodic acid followed by treatment of the intermediate oxidation product with trifluoroacetic acid. L-Glucose was prepared from L-glucurone by borohydride reduction and hydrolysis of the 1,2-O-isopropylidene derivative. Since 1 was derived from D-glucose, the result of this series of reactions was the conversion of D-glucose into its enantiomer L-glucose.
PDC-TREM, a plasmacytoid dendritic cell-specific receptor, is responsible for augmented production of type I interferon (2008)

Type I interferons (IFNs) derived from plasmacytoid dendritic cells (PDCs) are critical for antiviral responses; however, the mechanisms underlying their production remain unclear. We have identified a receptor, PDC-TREM, which is associated with Plexin-A1 (PlxnA1) on the PDC cell surface and is preferentially expressed after TLR-stimulation. Limited TLR signals induced PDC-TREM expression but failed to induce IFN-alpha production. However, when coupled with Sema6D, a ligand for Plexin-A1, limited TLR-stimulation resulted in PDC-TREM-mediated DAP12-dependent phosphorylation of phosphoinositide 3-kinase (PI3K) and extracellular regulated kinase (Erk) 1/2 at 6-9 h, and IFN-alpha was produced. Inhibition of PDC-TREM expression by pdctrem-shRNA, blocking of PDC-TREM-binding with PlxnA1 by PDC-TREM mAb, and DAP12 deficiency all resulted in greatly reduced PDC-TREM-dependent activation of signaling molecules and IFN-alpha production. Thus, PDC-TREM is responsible for IFN-alpha production, whereas TLR signals are essential for PDC-TREM expression.
Detection of circulating antigens in Gabonese patients with Loa loa filariasis (1996)

Circulating antigens were detected in sera of Gabonese patients with Loa loa filarial infection by co-electrosyneresis (Co-ES). The serum samples selected for this study were exposed to rabbit hyperimmune antifilarial antisera and human immune antisera: specific arcs were observed in 35/60 filarial patients, of whom 24/47 were microfilaraemic and 11/13 amicofilaraemic. The identity of rabbit hyperimmune antisera and loiasial immune sera was confirmed by the continuity of precipitation arcs. These preliminary studies were carried out to develop diagnostic tools for loiasis and to study the physiopathology of immune complexes.
Dynamic modeling and energy consumption analysis of crab walking of a six-legged robot (2011)

In this paper, an attempt has been made to develop a detailed dynamic model of a realistic six-legged robot during its crab motion. An energy consumption model has been derived for statically stable wave-crab gaits after considering a minimum of dissipating energy for optimal feet forces distributions. Two approaches, such as minimization of norm of feet forces and minimization of norm of joint torques have been developed. The performances of these approaches have been compared with each other for different values of duty factor. The effects of walking parameters, namely velocity, stroke, duty factor and crab angle are studied on energy consumption during crab walking. Wave gait with a lower duty factor is found to be more energy-efficient compared to that with the higher duty factor at the highest possible velocity.
Baseline and Dynamic Risk Predictors of Appropriate Implantable Cardioverter Defibrillator Therapy (2020)

Background Current approaches fail to separate patients at high versus low risk for ventricular arrhythmias owing to overreliance on a snapshot left ventricular ejection fraction measure. We used statistical machine learning to identify important cardiac imaging and time-varying risk predictors. Methods and Results Three hundred eighty-two cardiomyopathy patients (left ventricular ejection fraction ≤35%) underwent cardiac magnetic resonance before primary prevention implantable cardioverter defibrillator insertion. The primary end point was appropriate implantable cardioverter defibrillator discharge or sudden death. Patient characteristics; serum biomarkers of inflammation, neurohormonal status, and injury; and cardiac magnetic resonance-measured left ventricle and left atrial indices and myocardial scar burden were assessed at baseline. Time-varying covariates comprised interval heart failure hospitalizations and left ventricular ejection fractions. A random forest statistical method for survival, longitudinal, and multivariable outcomes incorporating baseline and time-varying variables was compared with (1) Seattle Heart Failure model scores and (2) random forest survival and Cox regression models incorporating baseline characteristics with and without imaging variables. Age averaged 57±13 years with 28% women, 66% white, 51% ischemic, and follow-up time of 5.9±2.3 years. The primary end point (n=75) occurred at 3.3±2.4 years. Random forest statistical method for survival, longitudinal, and multivariable outcomes with baseline and time-varying predictors had the highest area under the receiver operating curve, median 0.88 (95% CI, 0.75-0.96). Top predictors comprised heart failure hospitalization, left ventricle scar, left ventricle and left atrial volumes, left atrial function, and interleukin-6 level; heart failure accounted for 67% of the variation explained by the prediction, imaging 27%, and interleukin-6 2%. Serial left ventricular ejection fraction was not a significant predictor. Conclusions Hospitalization for heart failure and baseline cardiac metrics substantially improve ventricular arrhythmic risk prediction.
Challenges and Opportunities With Oncology Drug Development in China (2018)

Cancer is a growing public health problem in China. Despite the high unmet medical need of patients with cancer in China, oncology drug approvals have historically lagged behind those in the West, mainly the United States and Europe. China is currently undertaking regulatory reforms at a fast pace in order to mitigate this lag.
Modifications of the HEX program for fast automatic resolution of PIXE‐spectra (1982)

Abstract The computer program ‘HEX’ for resolving PIXE‐spectra has been modified. By irradiating standard foils, the escape peak ratios for x‐ray peaks in the energy interval 3.3‐10.6 keV have been measured. The results have been compared with theoretical calculations and experimental results of other research groups. The escape peaks have been included in the computer code. Pile‐up peaks in the x‐ray spectrum are also fitted by the modified computer program. This procedure is independent of the count rate and the pile‐up interval. In addition, an effective routine for rejecting small x‐ray peaks has been developed.
The Presence of Bacteriophages in the Human Body: Good, Bad or Neutral? (2020)

The presence of bacteriophages (phages) in the human body may impact bacterial microbiota and modulate immunity. The role of phages in human microbiome studies and diseases is poorly understood. However, the correlation between a greater abundance of phages in the gut in ulcerative colitis and diabetes has been suggested. Furthermore, most phages found at different sites in the human body are temperate, so their therapeutic effects and their potential beneficial effects remain unclear. Hence, far, no correlation has been observed between the presence of widespread crAssphage in the human population and human health and diseases. Here, we emphasize the beneficial effects of phage transfer in fecal microbiota transplantation (FMT) in <i>Clostridioides difficile</i> infection. The safety of phage use in gastrointestinal disorders has been demonstrated in clinical studies. The significance of phages in the FMT as well as in gastrointestinal disorders remains to be established. An explanation of the multifaceted role of endogenous phages for the development of phage therapy is required.
Draft Genomes for Eight Burkholderia mallei Isolates from Turkey (2016)

Burkholderia mallei, the etiologic agent of glanders, is a Gram-negative, nonmotile, facultative intracellular pathogen. Although glanders has been eradicated from many parts of the world, the threat of B. mallei being used as a weapon is very real. Here we present draft genome assemblies of 8 Burkholderia mallei strains that were isolated in Turkey.
Note: Piezoelectric strain voltage sensing at ultra-low frequencies (2011)

Piezoelectric sensors have emerged as a versatile tool for measurement of various quantities such as pressure, acceleration, strain, or force across many industrial applications. When mechanically strained, electric charges are produced inside a piezoelectric transducer. These charges result in an electric field that may be measured as a voltage difference between two electrodes, from which the strain can be inferred. To measure this voltage the sensor must be interfaced with an external device that would typically have a finite input impedance. This, together with the capacitive nature of the piezoelectric sensor, results in an inability to measure strain at low frequencies. We propose a method, based on using a varactor diode in an oscillator circuit, which can result in accurate measurements of the piezoelectric voltage at ultra-low frequencies. We demonstrate successful measurements at 1 mHz.
HYDROGEN TRAIPB-NUUEAR MAGNETIC RESONANCE FOR INDUSTRIAL MOISTURE 8EN8MG (1991)

Click to increase image sizeClick to decrease image sizeKeywords and Phrases: Grain DryingOn-Llne MeasurementProcess Control Instrumentation
Enzyme release and superoxide anion production by human alveolar macrophages stimulated with immunoglobulin E. (1980)

Human alveolar macrophages specifically released lysosomal beta-glucuronidase and neutral proteases when successively incubated with IgE, and then, for 30 min, with anti-IgE. Superoxide anion O2- generation was obtained when anti-IgE-opsonized zymosan was added to IgE-incubated cells. Macrophages from smokers excreted twice as much enzymes and superoxide as cells from non-smokers. It was possible to induce the specific release of beta-glucuronidase with normal alveolar macrophages successively incubated with the serum of patients allergic to house dust or to grass pollen and then with the specific allergen. This characteristic opens the field to a direct test for allergic sera by analogy with the allergen-induced degranulation test of sensitized basophils.
RESEARCH OF THE ROLL CROWN OPTIMIZATION ON SKIN PASS MILL IN BAOSTEEL 2050 HOT ROLLING PLANT (2002)

An optimized bending roll and roll crown designing method has been establi shed for uniform distribution of front transeverse tension, in this way, the contact width between work roll and back up roll is changed with the change of strip width, then the contact pressure becomes more homogeneous, the control by bending roll and then the strip shape are improved, roll consumption is reduced.
T-independent type II immune responses generate memory B cells (2006)

Unlike T-dependent immune responses against protein antigens, T-independent responses against polysaccharides confer long-lasting humoral immunity in the absence of recall responses and are not known to generate memory B cells. Here we report that polysaccharide antigens elicit memory B cells that are phenotypically distinct from those elicited by protein antigens. Furthermore, memory B cell responses against polysaccharides are regulated by antigen-specific immunoglobulin G antibodies. As the generation and regulation of immunologic memory is central to vaccination, our findings help explain the mode of action of the few existing polysaccharide vaccines and provide a rationale for a wider application of polysaccharide-based strategies in vaccination.