gebhart/patrepeval huggingface dataset:
Antibiotics As Tools for Metabolic Studies. VI. Damped Oscillatory Swelling of Mitochondria Induced by Nonactin, Monactin, Dinactin, and Trinactin* (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAntibiotics As Tools for Metabolic Studies. VI. Damped Oscillatory Swelling of Mitochondria Induced by Nonactin, Monactin, Dinactin, and Trinactin*Stanley N. Graven, Henry A. Lardy, and Anthony RutterCite this: Biochemistry 1966, 5, 5, 1735–1742Publication Date (Print):May 1, 1966Publication History Published online1 May 2002Published inissue 1 May 1966https://pubs.acs.org/doi/10.1021/bi00869a041https://doi.org/10.1021/bi00869a041research-articleACS PublicationsRequest reuse permissionsArticle Views59Altmetric-Citations63LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Solid-State, Rechargeable, Long Cycle Life Lithium–Air Battery (2009)

This paper describes a totally solid-state, rechargeable, long cycle life lithium–oxygen battery cell. The cell is comprised of a Li metal anode, a highly Li-ion conductive solid electrolyte membrane laminate fabricated from glass–ceramic (GC) and polymer–ceramic materials, and a solid-state composite air cathode prepared from high surface area carbon and ionically conducting GC powder. The cell exhibited excellent thermal stability and rechargeability in the temperature range. It was subjected to 40 charge–discharge cycles at current densities ranging from 0.05 to . The reversible charge/discharge voltage profiles of the cell with low polarizations between the discharge and charge are remarkable for a displacement-type electrochemical cell reaction involving the reduction of oxygen to form lithium peroxide. The results represent a major contribution in the quest of an ultrahigh energy density electrochemical power source. We believe that the cell, when fully developed, could exceed specific energies of 1000 Wh/kg in practical configurations.
Characterization of Shape and Monodispersity of Anisotropic Nanocrystals through Atomistic X-ray Scattering Simulation (2015)

Nanocrystals with anisotropic shape and high uniformity are now commonly produced as a result of significant advances in synthetic control. In most cases, the morphology of such materials is characterized only by electron microscopy, which makes the extraction of statistical information laborious and subject to bias. In this work, we describe how X-ray scattering patterns in conjunction with Debye formula simulations can be used to provide accurate atomisitic models for ensembles of anisotropic nanocrystals to complement and extend microscopic studies. Methods of sample preparation and measurement conditions are also discussed to provide appropriate experimental data. The scripts written to implement the Debye function are provided as a tool to allow researchers to obtain atomisitic models of nanocrystals.
Surgical outcomes of deep sclerectomy with collagen implant (2001)

We evaulated the effectiveness and adverse effects of deep sclerectomy with collagen implant (DSCI), which is a kind of nonpenetrating filtering surgery. In this retrospective study, DSCI was performed in 15 eyes of 11 glaucoma patients. An trabeculo-Descemet's membrane (TDM) window is created by a deep sclerokeratectomy, and the collagen implant is placed in the sclera bed under a superficial flap (deep sclerectomy with collagen implant). In 3 of 15 eyes the DSCI was intraoperatively converted to conventional filtering surgery for a large perforation of the TDM. These eyes were not included in the results of the surgical outcomes. The mean age of the patients was 50.3 +/- 14.4 years, and the mean follow-up period was 11.1 +/- 5.9 months. A diagnosis of chronic open angle glaucoma was made in 7 eyes and a diagnosis of secondary glaucoma in 5 eyes. The mean preoperative IOP was 25.8 +/- 11.9 mmHg, the immediate postoperative IOP was 6.4 +/- 2.9 mmHg, and at the final follow-up, the IOP was 11.9 +/- 2.5 mmHg. The IOP in 5 eyes was under 6 mmHg temporarily. However, there was no serious complication such as shallow anterior chamber. DSCI is considered to be a good surgical procedure that has similar surgical outcomes to a conventional trabeculectomy without serious complications.
Interoceptive Ability Predicts Survival on a London Trading Floor (2016)

Interoception is the sensing of physiological signals originating inside the body, such as hunger, pain and heart rate. People with greater sensitivity to interoceptive signals, as measured by, for example, tests of heart beat detection, perform better in laboratory studies of risky decision-making. However, there has been little field work to determine if interoceptive sensitivity contributes to success in real-world, high-stakes risk taking. Here, we report on a study in which we quantified heartbeat detection skills in a group of financial traders working on a London trading floor. We found that traders are better able to perceive their own heartbeats than matched controls from the non-trading population. Moreover, the interoceptive ability of traders predicted their relative profitability, and strikingly, how long they survived in the financial markets. Our results suggest that signals from the body - the gut feelings of financial lore - contribute to success in the markets.
X-ray Intermolecular Structure Factor (XISF): separation of intra- and intermolecular interactions from total X-ray scattering data (2015)

XISF is a MATLAB program developed to separate intermolecular structure factors from total X-ray scattering structure factors for molecular liquids and amorphous solids. The program is built on a trust-region-reflective optimization routine with the r.m.s. deviations of atoms physically constrained. XISF has been optimized for performance and can separate intermolecular structure factors of complex molecules.
Enterococcal Rgg-Like Regulator ElrR Activates Expression of the elrA Operon (2013)

The Enterococcus faecalis leucine-rich protein ElrA promotes virulence by stimulating bacterial persistence in macrophages and production of the interleukin-6 (IL-6) cytokine. The ElrA protein is encoded within an operon that is poorly expressed under laboratory conditions but induced in vivo. In this study, we identify ef2687 (renamed elrR), which encodes a member of the Rgg (regulator gene for glucosyltransferase) family of putative regulatory proteins. Using quantitative reverse transcription-PCR, translational lacZ fusions, and electrophoretic mobility shift assays, we demonstrate that ElrR positively regulates expression of elrA. These results correlate with the attenuated virulence of the ΔelrR strain in a mouse peritonitis model. Virulence of simple and double elrR and elrA deletion mutants also suggests a remaining ElrR-independent expression of elrA in vivo and additional virulence-related genes controlled by ElrR.
Aerodynamic steering of a 10 cm high-speed running robot (2013)

Turning while running at high speeds remains a difficult task for legged robots, but this capability is crucial for maneuvering quickly in a real-world environment. In this work we present a 10 cm long novel robot, SailRoACH, the first running robot that uses aerodynamic forces to turn. We present a scale analysis of aerodynamic steering, showing this steering method is most effective for small robots. Modeling and simulations were performed, and validated with experiments, that showed the robot is capable of stably turning in a 1.2 m radius at 1.6 ms <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> . We also show that aerodynamic steering is superior for high speed turns at high forward velocity, compared to existing methods. Additionally, aerodynamic steering allows us to introduce a constant yaw disturbance to the robot. This is useful for studying legged locomotion, and is difficult to achieve otherwise.
A 183 GHz Desensitized Unbalanced Cascode Amplifier With 9.5-dB Power Gain and 10-GHz Band Width and −2 dBm Saturation Power (2018)

A novel approach to design a mm-wave high power gain cascode amplifier is proposed. The gain is enhanced by adjusting the size of the cascode transistor together with a desensitized inductive impedance at its base. The impedance at this node has a critical role in determining both gain and stability. The employed desensitization technique decreases the effect of process variations and modeling errors on this impedance which results in a reliable design. Providing enough degrees of freedom, this method results in a conjugate matched input and output impedances. Therefore, two or more of this stage can be simply cascaded to get higher gain with no need for an interstage matching network and hence no additional loss and gain degradation. Based on this approach, a single stage amplifier at 183 GHz is implemented in a 130 nm SiGe process which has a measured power gain of 9.5 dB, 3 dB bandwidth of 8.5 GHz and saturation power of -2.8 dBm.
Non-invasive assessment of vascular reactivity in forearm skin of patients with primary Raynaud's phenomenon and systemic sclerosis (1996)

We have non-invasively assessed neurovascular control mechanisms in forearm skin of 10 healthy control subjects, eight patients with primary Raynaud's phenomenon (PRP) and 10 patients with systemic sclerosis (SSc) by iontophoresing acetylcholine (endothelial dependent), sodium nitroprusside (endothelial independent) and adrenaline, and measuring subsequent blood flow responses by dual-channel laser Doppler. Because basal forearm blood flow is low, adrenaline response was assessed by attenuation of reperfusion hyperaemia following 60 s of upper arm occlusion. Reperfusion hyperaemia prior to adrenaline iontophoresis differed significantly between groups (F2.21 = 4.3, P = 0.03), being lowest in the SSc and highest in the PRP group. However, the degree of attenuation of this hyperaemia by adrenaline did not differ between groups and all groups demonstrated similar vasodilatory responses to acetylcholine and to sodium nitroprusside. These findings may reflect that abnormalities in vascular tone in patients with Raynaud's phenomenon are local to the digits, or that vasoactive agents not examined in this study play a key role.
Obituary for Professor Yoel Kloog (2020)

A biochemist whose discoveries have led to a better understanding of Ras function in health and disease.Yoel Kloog was a passionate researcher of signaling in normal and diseased cells.His research has significantly contributed to the development of new concepts in signal transduction and to the design of potential therapeutic modalities for the treatment of severe diseases, including cancer, neurological disorders, such as head trauma and stroke, and immune-related diseases, including multiple sclerosis, lupus, restenosis, and atherosclerosis.Yoel Kloog was born in Israel in 1948.
Multiple interleukin‐1β–converting enzymes contribute to inflammatory arthritis (2009)

Mouse models of inflammatory arthritis are strongly driven by excessive production of interleukin (IL)-1β. Much attention has focused on the generation of IL-1β by inflammasomes and caspase 1 in monocytes and macrophages. However, a number of other proteases can also process pro-IL-1β into the mature, bioactive cytokine. Despite that arthritis has complex etiologies based on genetic and environmental factors, global blockage of IL-1β signaling strongly ameliorates experimental models of arthritis. Yet, the relative contribution of the different IL-1β processing enzymes to disease initiation and perpetuation is elusive. Two papers in this issue of Arthritis & Rheumatism by Joosten et al. and Guma et al. shed more light on the complex proteolytic mechanisms behind excessive IL-1β maturation and release that perpetuates experimental models of inflammatory arthritis, which will have significant implications for designing future treatment strategies.
Omega-3 polyunsaturated fatty acids and the inflammatory state of the Caco-2 gut epithelium model (2020)

Abstract The gut epithelium is a protective interface between the external environment and the human body. This epithelium interacts with a multitude of internal stimuli from the bloodstream and immune cells, and luminal stimuli from microorganisms and the diet. Disruptions to the epithelium are seen in inflammatory bowel diseases and coeliac disease. The human adenocarcinoma cell line (Caco-2) is an in vitro model used to assess the interactions between nutrients and gut epithelium. Long-chain omega-3 (n-3) polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have anti-inflammatory effects via the production of anti-inflammatory eicosanoids, interactions with immune cells and reductions in pro-inflammatory cytokines and chemokines. The aim of this study is to assess the anti-inflammatory properties of DHA and EPA in stimulated Caco-2 monolayers. Caco-2 cells were seeded at 70,000 cells/cm 2 and grown to confluence before being allowed to fully differentiate (approx. 21 days total). Cytokines (TNF-α, IFN-γ, and IL-1β) and peptic-tryptic (PT-) gliadin were used as inflammatory stimulants. EPA and DHA incubations occurred 48 hours pre-stimulation. Tight junction function and morphology was determined using trans-epithelial electrical resistance measurements and confocal microscopy. Inflammatory markers, including IL-6, IL-8, and IL-17, were assessed by multiplex. Stimulatory cytokines induced tight junction dysfunction and increased pro-inflammatory mediator production in Caco-2 cells. PT-gliadin, DHA and EPA treatment did not alter paracellular permeability or stimulant-induced production of pro-inflammatory mediators. Further investigation of the inflammatory role of n-3 PUFAs and PT-gliadin in the Caco-2 model is required. Future work will assess the composition of PT-gliadin by electrophoresis and whether co-incubation of n-3 PUFAs and inflammatory cytokines will alter paracellular permeability and mediator output of Caco-2 cells.
Advances and controversies in the study of programmed cell death/apoptosis in the development of and therapy for cancer (1994)

Whether normal or malignant, cells possess within their repertoire of epigenetic programs the ability to undergo a process of cellular suicide, termed programmed cell death. This programmed cell death process involves an epigenetic reprogramming of the cell that results in an energy-dependent cascade of biochemical and morphologic changes within the cell (also termed apoptosis), resulting in its death and elimination. Activation of programmed cell death is controlled by a series of endogenous cell-type-specific signals. In addition, various exogenous cell-damaging treatments (eg, radiation, chemicals, and viruses) can activate this pathway if sufficient injury to the cell occurs.
Obstructive sleep apnea syndrome and cognition in Down syndrome (2014)

These findings demonstrate a relation between OSAS and cognitive outcomes in Down syndrome. More work is required to fully understand the mechanisms underlying the links between poor sleep and impaired cognitive function. Overall, these findings highlight the importance of adequate sleep in typically and atypically developing populations.
Effects of pressure on the structure and lattice dynamics of TmPO4: Experiments and calculations (2012)

Thulium phosphate (TmPO${}_{4}$) with the tetragonal zircon-type structure has been studied using angle-dispersive powder x-ray diffraction and Raman spectroscopy in a diamond anvil cell up to 55 GPa (at room temperature). The results from both experimental methods reveal a pressure-induced structural phase transition from zircon to a scheelite-type structure at 20 GPa. At the same pressure, a second phase with the monazite structure is also formed at a low concentration, which decreases and eventually vanishes with increasing pressure. Our ab initio total-energy and lattice-dynamics calculations are in good agreement with experimental findings. The calculations indicate that the main transition to the scheelite structure is related with the softening of a silent ${B}_{1u}$ mode. Upon decompression, TmPO${}_{4}$ reverses back to the original zircon structure showing significant hysteresis. The results are discussed in relation to the observed general structural systematics and phase transition sequences in zircon-type $A$PO${}_{4}$ orthophosphates under pressure.
Ring and Disk‐Like CdSe Nanoparticles Stabilized with Copolymers (2003)

Abstract CdSe nanoparticles stabilized with the amphiphilic diblock copolymer polystyrene‐ block ‐poly(4‐vinylpyridine) were spread from toluene dispersion on the water surface. Monolayers could be transferred onto solid substrates using the Langmuir‐Blodgett technique. By means of atomic force and scanning electron microscopy highly symmetric ring and disk‐like structures with diameters ranging between 150 nm and 1200 nm were observed. AFM image of a mixed monolayer of copolymer 12 and CdSe nanoparticles stabilized with polystyrene‐ block ‐poly(4‐vinylpyridine). magnified image AFM image of a mixed monolayer of copolymer 12 and CdSe nanoparticles stabilized with polystyrene‐ block ‐poly(4‐vinylpyridine).
Quantitative evalution of the activity of the back muscles in lifting (1966)

It was our intention with the present investigation to work out a system by means of which it would be possible to estimate what load a person could be allowed to lift and hold in a forward inclined position with safety.
Growth and morphology of cadmium chalcogenides : the synthesis of nanorods, tetrapods, and spheres from CdO and Cd(O[2]CCH[3])[2]. (2003)

In this work, we investigated the controlled growth of nanocrystalline CdE (E = S, Se, and Te) via the pyrolysis of CdO and Cd(O2CCH3)2 precursors, at the specific Cd to E mole ratio of 0.67 to 1. The experimental results reveal that while the growth of CdS produces only a spherical morphology, CdSe and CdTe exhibit rod-like and tetrapod-like morphologies of temporally controllable aspect ratios. Over a 7200 s time period, CdS spheres grew from 4 nm (15 s aliquot) to 5 nm, CdSe nanorods grew from dimensions of 10.8 x 3.6 nm (15 s aliquot) to 25.7 x 11.2 nm, and CdTe tetrapods with arms 15 x 3.5 nm (15 s aliquot) grew into a polydisperse mixture of spheres, rods, and tetrapods on the order of 20 to 80 nm. Interestingly, long tracks of self-assembled CdSe nanorods (3.5 x 24 nm) of over one micron in length were observed. The temporal growth for each nanocrystalline material was monitored by UV-VIS spectroscopy, transmission electron spectroscopy, and further characterized by powder X-ray diffraction. This study has elucidated the vastly different morphologies available for CdS, CdSe, and CdTe during the first 7200 s after injection of the desired chalcogenide.
Purification, Properties and Immunological Detection of a Bromoperoxidase-Catalase from Streptomyces venezuelae and from a Chloramphenicol-nonproducing Mutant (1989)

A new bromoperoxidase-catalase was purified from the chloramphenicol-producing actinomycete Streptomyces venezuelae ISP 5230. The homogeneous enzyme showed brominating activity, catalase activity and a very low peroxidase activity. The spectral properties and pH dependence of the catalase activity showed similarities to conventional catalases. In contrast to other haem-bromoperoxidases, the bromoperoxidase-catalase was stable when treated with an ethanol/chloroform mixture. Gel filtration gave an estimated Mr of 127,000-136,000. SDS-PAGE showed a single band corresponding in mobility to a species with an Mr of 61,000. The pI was estimated to be 4.5. The bromoperoxidase-catalase was not present in active form in a mutant of S. venezuelae ISP 5230, blocked in the chlorination step of chloramphenicol biosynthesis. However, an inactive species of the enzyme was detected in crude extracts of the mutant by using antibodies. From these results it is concluded that this bromoperoxidase participates in the chlorination step during chloramphenicol biosynthesis.
A Virtual Machine Migration System Based on a CPU Emulator (2006)

Migration of virtual computing environments is a useful mechanism for advanced management of servers and utilization of a uniform computing environment on different machines. There have been a number of studies on migration of virtual computing environments based on virtual machine monitors (e.g., VMware) or language-level virtual machines (e.g., Java). However, migration systems based on a CPU emulator have not received much attention and their viability in a practical setting is not clear. In this paper, we describe Quasar, a virtual machine (VM) migration system implemented on top of the QEMU CPU emulator. Quasar can migrate a whole operating system between physical machines whose architectures are different (e.g., between an x86 machine and a PowerPC machine). Quasar provides a virtual networking facility, which allows migrating VMs to continue communication without disconnecting sockets for migration. Quasar also provides a staged migration function to reduce the downtime of migrating VMs. We have examined the viability of Quasar through experiments, in which Quasar was compared with Xen, SBUML, and UML. The experiments assessed the performance of virtual server hosting, the sizes of the files that represent VMs, and the amount of downtime for VM migration.
Prediction of wavefields by injecting multicomponent seismic measurements into modeling (2014)

Summary We show that by injecting the seismic wavefield measured on multicomponent sensors in streamers or on the sea bed into a time-space domain modeling scheme such as finite differences (FD), various wavefields can be predicted in a radically new way for use in processing, imaging and waveform inversion. Examples of wavefields that can be predicted per shot gather by using simple boundary conditions are the upgoing and downgoing waves (receiver-side ghosts), and the source radiation pattern (direct wave with source ghost). Applying more advanced boundary conditions at the edge of the injection model that use all the recorded data to account for the interaction with the unknown subsurface allows the prediction of the wavefield that would be recorded with the free-surface absent, or the prediction of the surface-related multiples of all orders. These novel modeling processes require no information of the subsurface. We also demonstrate how the upgoing and downgoing wavefields can be used in RTM with multiples (given a velocity model of the subsurface).