gebhart/patrepeval huggingface dataset:
Effect of short-term repeated administration of several psychoactive drugs on locomotor activity and cerebral monamine transmitters in mice (2001)

Objective To observe the effect of short-term repeated administration of several psychoactive drugs on locomotor activity and cerebral monamine transmitters in mice and evaluate tolerance of drug action and their side-effects. Methods Male mice were used as subjects. The experiment of central stimulants was divided into 3 groups (n=6 each): ①control;②caffeine(Caf) 30 mg/kg; ③dexamphetamine(Dex) 10 mg/kg. The experiment of hypnotics included 4 groups: ①control; ②triazolam (TZ) 0.04 mg/kg;③seconal (Sec) 60 mg/kg; ④melatonin (Mel) 120 mg/kg. These drugs were given orally to the mice once daily for 7 days. Body weight and locomotor activity were determined on first day and 7th day. After repeated administration of Dex and TZ for 7 days, monamine transmitters and their metabolites in mouse brain were determined by reverse phase HPLC with electrochemical detector. Results ①There was no significantly difference of body weight between the control and drug-treated groups. ②Stimulating action of Caf and Dex was significantly increased on 7th day (P<0.05, compared with first day). ③Although the significant sedative effect of hypnotics remained after repeated administration of hypnotics for 7 days, their potency was reduced(P<0.05, compared with first day). ④ No significant changes of monamine transmitters were found in cerebral cortices of mice after repeated administration of Dex and TZ for 7 days; but DOPAC and 5-HIAA in Dex group and 5-HIAA in TZ group was significantly decreased (P<0.05, compared with the control). Conclusion ①The sedative effect of several hypnotics was decreased after repeated medication; ②Dex and TZ might have detrimental effects on some monamine transmitter metabolites in mouse brain after continuous administration for one week.
A simple approach to coil design for vibrating sample magnetometers (1976)

The recent paper by Bragg and Seehra (1976), although welcome for its rigorous approach to the problem of the theoretical EMF obtainable from pickup coils used in vibrating sample magnetometers, is incomplete since it does not pin-point the crucial factors governing coil pickup efficiency. In addition these authors make some statements which would be misleading to the uninitiated and thus require further comment. An attempt is made to clear up these shortcomings and demonstrate an extremely simple approach to coil design which follows directly from a little-quoted paper by Mallinson (1966).
Puertos, sociedad y conflictos en el caribe colombiano, 1850 – 1930. Sergio Paolo Solano de Las Aguas. Observatorio del caribe colombiano, Universidad de Cartagena, Bogota, 2003. 115 Págs. (2022)

Puertos, sociedad y conflictos en el caribe colombiano, 1850 – 1930. Sergio Paolo Solano de Las Aguas. Observatorio del caribe colombiano, Universidad de Cartagena, Bogota, 2003. 115 Pags.
ANTIVIRAL ACTIVITY OF MYCOPHENOLIC ACID (1968)

Mycophenolic acid shows significant antiviral activity in the agar diffusion plaque inhibition, plaque reduction and tube culture methods. Both DNA and RNA viruses are involved in the antiviral spectrum and the chemotherapeutic index of mycophenolic acid is high against viruses in vitro.
Towards spontaneous speech recognition for on-board car navigation and information systems (1999)

This paper presents a hierarchical approach to the Large-Scale Speaker Recognition problem. In here the authors present a binary tree data-base approach for arranging the trained speaker models based on a distance measure designed for comparing two sets of distributions. The combination of this hierarchical structure and the distance measure [1] provide the means for conducting a large-scale verification task. In addition, two techniques are presented for creating a model of the complement-space to the cohort which is used for rejection purposes. Results are presented for the drastic improvements achieved mainly in reducing the false-acceptance of the speaker verification system without any significant false-rejection degradation.
Probiotic Properties of Lactobacillus Salivarius and Closely Related Lactobacillus Species (2010)

Lactobacillus salivarius has been frequently isolated from the mammalian digestive tract and has been studied as a candidate probiotic. Research to date has described the immunomodulatory properties of the species in cell-lines, mice, rats and humans for the alleviation of intestinal disease and the promotion of host well-being. The ability of L. salivarius to inhibit pathogens and tolerate host antimicrobial defenses demonstrates the adaptation of this species to the gastrointestinal niche. L. salivarius is the best characterized of 25 species in the L. salivarius clade of the genus Lactobacillus. Several other species of this clade are candidate probiotics; however, their probiotic potential has not yet been exploited. This review summarizes the research defining the probiotic nature of L. salivarius, by focusing in particular on L. salivarius UCC118 as a representative strain. The emergent research detailing the probiotic potential of other species in this phylogenetic clade will also be discussed.
DNA-Templated Timer Probes for Multiplexed Sensing (2020)

Simultaneous analysis based on encoded fluorophores suffers from potential crosstalk between fluorophores and the limited number of colors that can be practically resolved. Inspired by nontrivial temporal patterns in living organisms, we developed a DNA-templated probe by utilizing DNA polymerase (DNAP) for multiplexed detection of nucleic acids. These probes use differential delay times of signaling by a DNAP-mediated extension to distinguish different targets, which serve as the primers. Taking advantage of the high processivity and the controllable kinetics of DNAP, we find that multiplexed detection can be achieved in homogeneous solution using a single fluorophore. As a proof of concept, we developed assays for genomic DNA from four different bacteria. In addition, we designed and implemented probes to undergo a single oscillation in signal as an alternative way for multiplexing. We anticipate this approach will find broad applications not only in sensing but also in synthetic DNA nanosystems.
Electro-optic and electro-absorption characterization of InAs quantum dot waveguides (2008)

Optical properties of multilayer InAs quantum dot waveguides, grown by molecular beam epitaxy, have been studied under applied electric field. Fabry-Perot measurements at 1515 nm on InAs/GaAs quantum dot structures yield a significantly enhanced linear electro-optic efficiency compared to bulk GaAs. Electro-absorption measurements at 1300 nm showed increased absorption with applied field accompanied with red shift of the spectra. Spectral shifts of up to 21% under 18 Volt bias was observed at 1320 nm.
The Ligand-binding Properties of Hemoglobin Hiroshima (α2β2146 asp) (1972)

Hemoglobin Hiroshima is a β chain variant of human hemoglobin in which aspartate is substituted for histidine at position 146. From chemical and crystallographic studies, it has been postulated that the histidine normally found at this position stabilizes the deoxy conformation by both inter- and intra-chain salt linkages and releases Bohr protons during ligand binding. Previous equilibrium studies had shown that hemoglobin Hiroshima does exhibit an increased oxygen affinity and a reduced alkaline Bohr effect. Kinetic studies of the carbon monoxide and n-butyl isocyanide binding reaction show that deoxyhemoglobin Hiroshima in low ionic strength buffers exhibits behavior intermediate between that of the isolated chains and that of deoxyhemoglobin A at neutral pH. At pH 7.0, the time course of both of these reactions exhibited little or no wave length dependence, suggesting that the α and β chains within deoxyhemoglobin Hiroshima react with ligands at similar apparent association rates. This result is in contrast to previous studies both with isolated chains and with deoxyhemoglobin A at this pH. However, similar behavior has been observed for deoxyhemoglobin A at pH 9.1 and des(his 146 β)deoxyhemoglobin at pH 7.0. Further analysis of the available kinetic and spectral data indicates that the intermediate ligand binding behavior of deoxyhemoglobin Hiroshima is not a result of an equilibrium distribution of deoxy A-like and liganded A-like conformations, but rather represents the properties of a new and distinct protein conformation which results from the disruption of the salt linkages at the COOH terminus of the β chains by either deprotonating, physically removing, or substituting aspartate for histidine 146 β.
Detection of flowing samples with a selective concentration gradient method (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetection of flowing samples with a selective concentration gradient methodJanusz. PawliszynCite this: Anal. Chem. 1988, 60, 8, 766–773Publication Date (Print):April 15, 1988Publication History Published online1 May 2002Published inissue 15 April 1988https://pubs.acs.org/doi/10.1021/ac00159a008https://doi.org/10.1021/ac00159a008research-articleACS PublicationsRequest reuse permissionsArticle Views81Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Ultra Wideband Digital Recording Techniques. (1977)

Abstract : Design, modifications, test, evaluation and analysis were made on a predistortion encoder, record equalizer, HDMR head, playback preamplifier, delay modulation detector, and computer tape transport. Performance and performance limits were analyzed and applied to the modulation and coding, tape and head-tape interface, and magnetic heads technologies. (Author)
Self-directed growth of iron core–shell oval-shaped nanorods and nanocubes on a H-terminated Si(100) substrate in an external magnetic field (2007)

Iron core–shell oval-shaped nanorods and nanocubes were electrodeposited on a H-terminated Si(100) substrate with and without the presence of an externally applied magnetic field (with a flux density of 1.3 T). The presence of an external magnetic field during electrodeposition was found to produce clustering of oval-shaped nanorods with short-range ordering in the long-axis orientation, and to induce self-assembly of nanocubes into stripes along the field-line direction. Glancing-incidence x-ray diffraction showed that the magnetic field also changed the distribution of the crystal orientations of the Fe nanocubes. An external magnetic field applied during electrodeposition could therefore be used to manipulate the spatial and crystallographic arrangements of the deposited Fe nanoparticles.
Conclusion générale (1993)

Au terme d’une migration paysanne commencée deux cents ans auparavant, voici donc les représentants de cette paysannerie originaire du centre du pays installés à quelques heures de marche seulement de la côte Pacifique.Pour chaque étape de ce glissement démographique, l’identification des groupes sociaux concernés par l’émigration, de leurs intérêts respectifs différents et contradictoires et des moyens dont ils disposent permet de comprendre qui sont ces p
Single Chip Multisystem AM Stereo Decoder IC (1986)

We developed a single chip AM stereo decoder IC, which can demodulate three AM stereo systems, and automatically switch to the receiving system.
Effects ofSaccharomyces cerevisiaeextract on haematological parameters, immune function and the antioxidant defence system in breeder hens fed aflatoxin contaminated diets (2011)

The study was conducted to investigate the efficacy of Saccharomyces cerevisiae extract (SC) on haematological parameters, immune function, and the antioxidant defence system in breeder hens fed a diet contaminated with low level aflatoxin (AF). Forty-eight Ross 308 breeder hens were fed on diets containing AF (0 or 100 µg/kg) and SC (0 or 1 g/kg) in a 2 × 2 factorial arrangement. Red blood cell (RBC), white blood cell (WBC), and platelet counts, differential leucocyte counts, blood CD3+, CD4+, CD8+ and CD5+ T cell ratios, phagocytic activity and oxidative burst of heterophils, plasma and liver catalase activity, and malondialdehyde (MDA) and ascorbic acid concentrations were measured. 3. Plasma and liver MDA concentrations increased (P < 0·05), liver catalase activity decreased (P < 0·05) and total WBC count tended to decrease (P = 0·082) in hens fed the contaminated diet. WBC count, monocyte percentage, phagocytic activity and oxidative burst of heterophils increased (P < 0·05), and plasma MDA concentration tended to decrease (P = 0.088) in SC extract supplemented hens. There was a significant interaction between AF and SC on heterophil, lymphocyte, CD5+ cell percentages, and plasma catalase activity. Blood heterophil percentage decreased but lymphocyte percentage increased in hens fed on the AF contaminated diet without SC supplementation. SC supplementation counteracted the negative effect of AF on heterophils and lymphocytes. The CD5+ cell percentage decreased in unsupplemented hens fed the AF contaminated diet and this negative effect was minimised in SC supplemented hens. Plasma catalase activity increased in SC supplemented hens fed the uncontaminated diet whereas the effect of SC decreased in hens fed the AF contaminated diet. 4. The SC reduced some of the some adverse effects of AF, and improved functions of the non-specific immune system. Therefore, the SC extract which has been used for improving productive performance in birds and mammals may also be useful for modulating some of the effects of a low level, chronic dosage of AF.
Effect of the angle of incidence on optical second harmonic generation at the electrode-electrolyte interface (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of the angle of incidence on optical second harmonic generation at the electrode-electrolyte interfaceA. Tadjeddine and P. Guyot-SionnestCite this: J. Phys. Chem. 1990, 94, 12, 5193–5195Publication Date (Print):June 1, 1990Publication History Published online1 May 2002Published inissue 1 June 1990https://pubs.acs.org/doi/10.1021/j100375a078https://doi.org/10.1021/j100375a078research-articleACS PublicationsRequest reuse permissionsArticle Views85Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
The effects of Ca2+ and Cd2+ on the secondary and tertiary structure of bovine testis calmodulin. A circular-dichroism study (1986)

Near-u.v. and far-u.v. c.d. spectra of bovine testis calmodulin and its tryptic fragments (TR1C, N-terminal half, residues 1-77, and TR2C, C-terminal half, residues 78-148) were recorded in metal-ion-free buffer and in the presence of saturating concentrations of Ca2+ or Cd2+ under a range of different solvent conditions. The results show the following: if there is any interaction between the N-terminal and C-terminal halves of calmodulin, it has not apparent effect on the secondary or tertiary structure of either half; the conformational changes induced by Ca2+ or Cd2+ are substantially greater in TR2C than they are in TR1C; the presence of Ca2+ or Cd2+ confers considerable stability with respect to urea-induced denaturation, both for the whole molecule and for either of the tryptic fragments; a thermally induced transition occurs in whole calmodulin at temperatures substantially below the temperature of major thermal unfolding, both in the presence and in the absence of added metal ion; the effects of Cd2+ are identical with those of Ca2+ under all conditions studied.
Hsp90 inhibition increases SOCS3 transcript and regulates migration and cell death in chronic lymphocytic leukemia (2016)

Epigenetic or transcriptional silencing of important tumor suppressors has been described to contribute to cell survival and tumorigenesis in chronic lymphocytic leukemia (CLL). Using gene expression microarray analysis, we found that thousands of genes are repressed more than 2-fold in CLL compared to normal B cells; however therapeutic approaches to reverse this have been limited in CLL. Following treatment with the Hsp90 inhibitor 17-DMAG, a significant number of these repressed genes were significantly re-expressed. One of the genes significantly repressed in CLL and up-regulated by 17-DMAG was suppressor of cytokine signaling 3, (SOCS3). SOCS3 has been shown to be silenced in solid tumors as well as myeloid leukemia; however little is known about the regulation in CLL. We found that 17-DMAG induces expression of SOCS3 by via the activation of p38 signaling, and subsequently inhibits AKT and STAT3 phosphorylation resulting in downstream effects on cell migration and survival. We therefore suggest that SOCS3 is an important signaling protein in CLL, and Hsp90 inhibitors represent a novel approach to target transcriptional repression in B cell lymphoproliferative disorders which exhibit a substantial degree of gene repression.
Quality Assurance Requirements for a Large LI/SOCl2 Battery for Spacecraft Applications (1987)

A large lithium thionyl chloride (Li/SOCl2) spacecraft battery is currently being fabricated. When flown, this battery will consist of as many as 1080 F-size cells with an ultimate capacity of more than 2000 A-h. This work presents the acceptance and qualification test flows used for evaluating and screening the cells that compose the modules and battery assemblies. We also present data and analyses on the acceptance and qualification testing of the Li/SOCl2 cells. On the average, these F cells have a mean capacity of 18 A-h; select lots meet our goal of having less than a 5% coefficient of variation for the cell capacity.
A Machine Learning Approach to Identify a Circulating MicroRNA Signature for Alzheimer Disease (2019)

Although additional and more diverse cohorts are needed for further clinical validation of the robustness, the miRNA signature appears to be a promising blood test to diagnose AD.
ChemInform Abstract: The Suzuki Reaction under Solvent‐Free Conditions. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Additional file 8: Figure S5. of Comparative genomic analyses reveal broad diversity in botulinum-toxin-producing Clostridia (2016)

Dendrograms clustering Group I and Group II strains by BSR values. A) A dendrogram generated by clustering Group I strains by BSR values with an average linkage method in MeV [76]. B) A dendrogram generated by clustering Group II strains by BSR values with an average linkage method in MeV [76]. (PDF 41 kb)
A distinctive facial appearance in neurofibromatosis von recklinghausen (1985)

Abstract Three children with neurofibromatosis from two unrelated families have unusual facial appearance due to telecanthus, antimongoloid slant of the palpebral fissures, broad nose, and tapering chin. The two boys have large hands and feet, and one is very tall. There were some facial and dermatoglyphic similarities to individuals with the Noonan syndrome, but the manifestations in the children reported here are sufficiently different to suggest the presence of a different type of neurocristopathy in these individuals.
A note on the primal-dual method for the semi-metric labeling problem (2007)

Recently, Komodakis et al. [6] developed the FastPD&#13;\nalgorithm for the semi-metric labeling problem, which extends&#13;\nthe expansion move algorithm of Boykov et al. [2]. We&#13;\npresent a slightly different derivation of the FastPD method.
Cationic Palladium/Boxax Complexes for Catalytic Asymmetric Wacker-Type Cyclization (1998)

Catalyticasymmetric Wacker-type cyclization of 2-(2,3-dimethyl-2-butenyl)phenol (1a) was efficiently catalyzed by 1 or 2 mol % of a cationic palladium−boxax complex generated in situ by mixing Pd(CH3CN)4(BF4)2 with (S,S)-ip-boxax (3a) in the presence of p-benzoquinone to give (S)-(−)-2-isopropenyl-2-methyl-2,3-dihydrobenzofuran (2a) in 94−96% ee and 45−85% yield. An X-ray diffraction study of the crystal structure of Pd(OCOCF3)2{(S,S)-ip-boxax} (6) revealed that the orientation of alkyl substituents on the boxax ligand is perpendicular to the plane of the square planar complex.
Biologie et épidémiologie de l'agent de la maladie des taches noires de la mangue (1995)

La maladie des taches noires ou bactériose fait peser une menace sérieuse sur la production de mangues (Mangifera indica L.) dans de nombreux pays tropicaux ou subtropicaux. Une analyse précise des connaissances acquises sur Xanthomonas campestris pv mangiferaeindicae , agent de cette maladie, a été effectuée. Elle prend en compte différentes composantes permettant de caractériser l'activité de la bactérie ; répartition géographique, symptomatologie, biologie, épidémiologie, modes de conservation et de dissémination sont ainsi tour à tour considérés. L'étude débouche sur un énoncé de mesures permettant d'adopter une véritable stratégie de lutte pour maintenir l'incidence de la maladie des taches noires de la mangue bien en-decà de son seuil de nuisibilité économique.