gebhart/patrepeval huggingface dataset:
Abstract A13: Clinical characteristics of responders to nivolumab plus ipilimumab (Nivo/Ipi) in metastatic uveal melanoma (2020)

Abstract In the U.S., prospective clinical trial data regarding nivolumab plus ipilimumab for metastatic uveal melanoma have yet to be reported. Here we present clinical data regarding responders to nivolumab plus ipilimumab that occurred in the context of a prospective clinical trial. NCT01585194 is an open-label, phase II study of nivolumab in combination with ipilimumab for the treatment of metastatic uveal melanoma. Patients with confirmed metastatic uveal melanoma received nivolumab 1 mg/kg followed by ipilimumab 3 mg/kg every 3 weeks for 4 doses, followed by up to 2 years of nivolumab maintenance. Response was evaluated using irRC beginning at week 12 and every 12 weeks thereafter. Responses were rare, but were seen in 3 patients, all female, with a mean age of 48. These subjects had hepatic M1b metastases (67%) and extrahepatic M1a metastasis (33%), and all three patients experienced a partial response at the first restaging, after 4 doses of Nivo/Ipi. Two additional patients, who came off study after two doses prior to response evaluation, one due to protocol-limiting hyperglycemia, and the other due to hyperuricemia and AKI, with M1b and M1a hepatic metastases, respectively, experienced partial responses. The first of these patients continued on additional Nivo/Ipi and developed a partial response 6 months after clinical trial initiation. The second patient never resumed additional treatment for metastatic disease. Her restaging scans 2 months after clinical trial initiation showed partial response; five months after initiation, her response continues with &amp;gt;70% reduction in tumor burden. Responders to Nivo/Ipi had the following immune-mediated toxicities: endocrinopathy, vitiligo, diarrhea, pneumonitis, transaminitis, hyperglycemia, and nephritis. Baseline tissue analysis on one of the responders showed sheets of cytotoxic T lymphocytes invading the tumor in a biopsy specimen. Responses to Nivo/Ipi in metastatic uveal melanoma are not confined to extrahepatic sites. In our study, 4 of 5 (80%) responses were seen in hepatic metastases. Durability of responses and impact on overall survival remain to be seen, and tissue-based exploratory correlative studies are under way. Citation Format: Michael Paul Shephard, Maura Glover, Gener Balmes, Suzanne Cain, Anna Vardeleon, Rosalind Mouton, Liberty Posada, Rinata Simien, Patrick Hwu, Michael Davies, Cassian Yee, Michael Wong, Hussein Tawbi, Scott Woodman, Rodabe Amaria, Adi Diab, Isabella Glitza, Wen-Jen Hwu, Sapna Patel. Clinical characteristics of responders to nivolumab plus ipilimumab (Nivo/Ipi) in metastatic uveal melanoma [abstract]. In: Proceedings of the AACR Special Conference on Melanoma: From Biology to Target; 2019 Jan 15-18; Houston, TX. Philadelphia (PA): AACR; Cancer Res 2020;80(19 Suppl):Abstract nr A13.
Near-Field Scanning Optical Microscope with a Laser Trapped Probe (1994)

We made an experiment of near-field microscopic imaging using a laser-beam trapped probe. Differently from a conventional near-field (and/or photon-tunneling) scanning optical microscope, the probe is physically isolated from the scanning microscope system; it is trapped and scanned on the sample surface by the radiation force of near-infrared laser beam. The distance between the probe and the sample surface is maintained to be constant (zero) during scanning. Another laser beam for microscopic imaging is incident on the sample surface in the condition of total internal reflection; the probe on the sample couples with the photons localized near the sample surface as the evanescent filed and scatters out. The scattered photons are collected through an microscope objective lens, which is the same lens as the one used for focusing the infrared laser beam on the probe. A near-field image of the sample surface is formed, as the probe is laterally scanned on the sample. The experimental setup of the proposed microscope is described and the image data obtained with the developed microscope are shown for refractive samples and fluorescent samples with sub micrometer structure.
The Mobile Robot for Garbage Sorting and Handling Based on Machine Vision (2021)

Recent years, garbage sorting has attracted wide attention from all aspects of society. Various methods and policies for garbage sorting have been put forward, which started from cultivating people's active awareness of garbage sorting. With the development of machine vision and deep learning, applying these techniques to intelligent garbage sorting will be a worthy direction. A mobile robot for garbage sorting and handling based on machine vision and GPS auto-drive technology was designed in this paper. The scheme was elaborated from three aspects of mechanical structure, hardware system, and software system. The test results showed that the PID speed regulation response of the mobile robot was fast, and the accuracy rates for recyclable garbage and hazardous garbage were respectively 100% and 80%.
Organic Offset Deposition by Innovative Plasma Technology: Channel Length Modulation for NOR Flash Memories (2008)

NOR flash memories typically use a Self Aligned Source (SAS) approach to increase array density and reduce device size. A low resistance source line common to adjacent cells in different bitlines is obtained by etching field oxide and implanting N-type dopant. The thin organic layer left by reactive ion etch (RIE) acts as a spacer during the implantation step, impacting the effective channel length and the source line resistance. Cell parameter variations induced by unpredictable changes of this film cannot be neglected as second order effects for 65nm and subsequent technology nodes. This paper discusses a new plasma technology application focused on this topic: after removing the organic film left by RIE, a tunable offset spacer has been purposely deposited on cell sidewalls and characterized by means of TEM analyses. The corresponding electrical impact on cell properties is reported and discussed.
Signalling lymphocyte activation molecule family member 9 is found on select subsets of antigen‐presenting cells and promotes resistance to Salmonella infection (2019)

Signalling lymphocyte activation molecule family member 9 (SLAMF9) is an orphan receptor of the CD2/SLAM family of leucocyte surface proteins. Examination of SLAMF9 expression and function indicates that SLAMF9 promotes inflammation by specialized subsets of antigen-presenting cells. Within healthy liver and circulating mouse peripheral blood mononuclear cells, SLAMF9 is expressed on CD11b<sup>+</sup> , Ly6C<sup>-</sup> , CD11c<sup>low</sup> , F4/80<sup>low</sup> , MHC-II<sup>+</sup> , CX<sub>3</sub> CR1<sup>+</sup> mononuclear phagocytes as well as plasmacytoid dendritic cells. In addition, SLAMF9 can be found on peritoneal B1 cells and small (F4/80<sup>low</sup> ), but not large (F4/80<sup>high</sup> ), peritoneal macrophages. Upon systemic challenge with Salmonella enterica Typhimurium, Slamf9<sup>-/-</sup> mice were impaired in their ability to clear the infection from the liver. In humans, SLAMF9 is up-regulated upon differentiation of monocytes into macrophages, and lipopolysaccharide stimulation of PMA-differentiated, SLAMF9 knockdown THP-1 cells showed an essential role of SLAMF9 in production of granulocyte-macrophage colony-stimulating factor, tumour necrosis factor-α, and interleukin-1β. Taken together, these data implicate SLAMF9 in the initiation of inflammation and clearance of bacterial infection.
EXTRACELLULAR HSP70 AND CELLULAR REPROGRAMMING (2004)

SOCIETY OF CRITICAL CARE MEDICINE 34TH CRITICAL CARE CONGRESS PHOENIX, ARIZONA, USA JANUARY 15-19, 2005: Oral Presentation: Basic Science: Infections and Inflammation
Development of Physics in Future stimulated by Frequency Measurement (2017)

1．はじめに
ENU mutagenesis identifies mice with mitochondrial branched-chain aminotransferase deficiency resembling human maple syrup urine disease (2004)

Tandem mass spectrometry was applied to detect derangements in the pathways of amino acid and fatty acid metabolism in N-ethyl-N-nitrosourea-treated (ENU-treated) mice. We identified mice with marked elevation of blood branched-chain amino acids (BCAAs), ketoaciduria, and clinical features resembling human maple syrup urine disease (MSUD), a severe genetic metabolic disorder caused by the deficiency of branched-chain alpha-keto acid dehydrogenase (BCKD) complex. However, the BCKD genes and enzyme activity were normal. Sequencing of branched-chain aminotransferase genes (Bcat) showed no mutation in the cytoplasmic isoform (Bcat-1) but revealed a homozygous splice site mutation in the mitochondrial isoform (Bcat-2). The mutation caused a deletion of exon 2, a marked decrease in Bcat-2 mRNA, and a deficiency in both BCAT-2 protein and its enzyme activity. Affected mice responded to a BCAA-restricted diet with amelioration of the clinical symptoms and normalization of the amino acid pattern. We conclude that BCAT-2 deficiency in the mouse can cause a disease that mimics human MSUD. These mice provide an important animal model for study of BCAA metabolism and its toxicity. Metabolomics-guided screening, coupled with ENU mutagenesis, is a powerful approach in uncovering novel enzyme deficiencies and recognizing important pathways of genetic metabolic disorders.
Iterative learning control for human-robot collaborative output tracking (2016)

This article studies human-robot learning control for collaborative output-tracking tasks. We propose an algorithm to adaptively tune the frequency-dependent iteration gain and apply it to two cases: when the desired output is directly available to the robot and when the robot infers the desired output from human-achieved output. Experiment results are presented to illustrate the application of the proposed approach to a human-robot collaborative output-tracking task. Results show that the error converges to less than the closed-loop robot tracking error, and that the approach can provide varying levels of robot assistance by selecting the desired human-robot collaboration level.
Resonant tunnelling and negative differential conductance in graphene transistors (2013)

The chemical stability of graphene and other free-standing two-dimensional crystals means that they can be stacked in different combinations to produce a new class of functional materials, designed for specific device applications. Here we report resonant tunnelling of Dirac fermions through a boron nitride barrier, a few atomic layers thick, sandwiched between two graphene electrodes. The resonance occurs when the electronic spectra of the two electrodes are aligned. The resulting negative differential conductance in the device characteristics persists up to room temperature and is gate voltage-tuneable due to graphene's unique Dirac-like spectrum. Although conventional resonant tunnelling devices comprising a quantum well sandwiched between two tunnel barriers are tens of nanometres thick, the tunnelling carriers in our devices cross only a few atomic layers, offering the prospect of ultra-fast transit times. This feature, combined with the multi-valued form of the device characteristics, has potential for applications in high-frequency and logic devices.
Diffraction-free planar beams in unbiased photorefractive media (1996)

We show that a new class of nondiffracting planar beams is possible in unbiased photorefractive media.
Effect of lift-off conditions on micropatterning of nanocrystalline quantum dot films (2017)

A micropatterning of nanocrystalline quantum dots (NQD) films using lift-off process has been proposed and experimentally demonstrated earlier. In this paper, the conditions of patterning process are investigated in order to define process parameters window for the lift-off procedure. The patterning of NQD CdSe/ZnS films using lift-off is studied in terms of photoresist thickness, solvent composition, and substrate material. The outcome of the process is monitored by means of fluorescence microscopy, atomic force microscope, and optical microscopy. The results show that patterns less than 1 μm can be resolved in NQD films with minimal alteration of the film characteristics, provided the photoresist layer is thicker than about 100 nm and acetone used as a solvent is spiked with toluene up to 10% of the solvent volume. The performance of the process in terms of resolution and film quality was found to be independent of the substrate used.
About 20 Years of Silicon‐Based Thin‐Film Sensors with Chalcogenide Glass Materials for Heavy Metal Analysis: Technological Aspects of Fabrication and Miniaturization (2007)

Abstract Chalcogenide glass materials as membranes for potentiometric sensors for chemical analysis in solutions, e.g., ion‐selective electrodes, have been studied for more than three decades. Already in the 1970's, first papers dealt with the ion‐sensing properties of chalcogenide glasses, followed by systematic investigations of their solid‐state chemistry, the sensing mechanism and their analytical characteristics. Combining the analytical performance of chalcogenide glass membranes with techniques originally invented for semiconductor processing, a new generation of silicon‐based thin‐film sensors with chalcogenide glass materials for heavy metal detection has been created. In the beginning, co‐sputtering of Cu and As 2 Se 3 resulted in a Cu 2+ ‐selective field‐effect sensor, while in recent years, a variety of chalcogenide glass materials have been stoichiometrically deposited onto ISFETs (ion‐sensitive field‐effect transistor), EIS (electrolyte‐insulator‐semiconductor), LAPS (light‐addressable potentiometric sensor) and μISE structures, respectively, serving as miniaturized chemical sensors. The present review paper is devoted to research and development in the field of silicon‐based thin‐film sensors with chalcogenide glass materials and emphasizes technological aspects of fabrication and miniaturization within the last 20 years.
Multiple scattering of light in porous glass (1994)

Two kinds of multiple-light-scattering measurements were performed for porous glass plates of several pore radii from 0.15 to 0.50 \ensuremath{\mu}m. One is the measurement of the angular dependence of the backscattered light intensity, and the other is the measurement of the temporal profile of light pulses transmitted through the sample. The measured curves were in very good agreement with the theoretical ones based on the diffusion model in uniform scattering media, and no features specific to the local geometry of porous glass were found. The pore radius dependence of the transport mean free path ${\mathit{l}}^{\mathrm{*}}$ could be explained well by a Mie scattering calculation based on the independent scattering approximation. The transport velocity of light in the porous glasses in the measured range of the pore size calculated from the obtained values of ${\mathit{l}}^{\mathrm{*}}$ and the diffusion constants was around 60% of the phase velocity in the bulk glass.
Protocol for detection of mycobacterium paratuberculosis in crohn's disease patients (2009)

We developed a detailed protocol for technology that detects Mycobacterium avium paratuberculosis (MAP) in blood derivatives samples from human by culture and PCR. The technology has potential to be used for screening blood samples from millions of patients with inflammatory and non-inflammatory bowel diseases for MAP.
Extending WebML for modeling multi-channel context-aware web applications (2004)

This paper focuses on conceptual modeling of multichannel, context aware Web applications, and in particular, proposes some solutions conceived within the WebML method. WebML is a conceptual model for data-intensive Web applications, which already offers some constructs for one-to-one personalization and multi-channel deliver. In this paper, we introduce some new extensions that allow representing a context model at data level, and exploit it at hypertext level for offering context-aware, customized services and contents, accessible through multiple channels.
Periodic poling of flux grown KTP (1997)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text H. Karlsson, M. Pierrou, and F. Laurell, "Periodic poling of flux grown KTP," in Advanced Solid State Lasers, C. Pollock and W. Bosenberg, eds., Vol. 10 of OSA Trends in Optics and Photonics Series (Optica Publishing Group, 1997), paper VL6. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Fast Parallel PageRank: A Linear System Approach (2004)

In this paper we investigate the convergence of iterative stationary and Krylov subspace methods for the PageRank linear system, including the convergence dependency on teleportation. We demonstrate that linear system iterations converge faster than the simple power method and are less sensitive to the changes in teleportation. In order to perform this study we developed a framework for parallel PageRank computing. We describe the details of the parallel implementation and provide experimental results obtained on a 70-node Beowulf cluster.
Correction to: Indirect and direct routes to C-glycosylated flavones in Saccharomyces cerevisiae (2018)

Upon publication of this article [1], it was brought to our attention that revised Fig. 1 supplied by the author during proof correction was unfortunately not presented in the original version of the article. The revised Fig. 1 is given in this erratum.
Suppression of the Macrophage Proteasome by Ethanol Impairs MHC Class I Antigen Processing and Presentation (2013)

Alcohol binge-drinking (acute ethanol consumption) is immunosuppressive and alters both the innate and adaptive arms of the immune system. Antigen presentation by macrophages (and other antigen presenting cells) represents an important function of the innate immune system that, in part, determines the outcome of the host immune response. Ethanol has been shown to suppress antigen presentation in antigen presenting cells though mechanisms of this impairment are not well understood. The constitutive and immunoproteasomes are important components of the cellular proteolytic machinery responsible for the initial steps critical to the generation of MHC Class I peptides for antigen presentation. In this study, we used an in-vitro cell culture model of acute alcohol exposure to study the effect of ethanol on the proteasome function in RAW 264.7 cells. Additionally, primary murine peritoneal macrophages obtained by peritoneal lavage from C57BL/6 mice were used to confirm our cell culture findings. We demonstrate that ethanol impairs proteasome function in peritoneal macrophages through suppression of chymotrypsin-like (Cht-L) proteasome activity as well as composition of the immunoproteasome subunit LMP7. Using primary murine peritoneal macrophages, we have further demonstrated that, ethanol-induced impairment of the proteasome function suppresses processing of antigenic proteins and peptides by the macrophage and in turn suppresses the presentation of these antigens to cells of adaptive immunity. The results of this study provide an important mechanism to explain the immunosuppressive effects of acute ethanol exposure.
Adaptive compression-based approach for Chinese Pinyin input (2004)

This article presents a compression-based adaptive algorithm for Chinese Pinyin input. There are many different input methods for Chinese character text and the phonetic Pinyin input method is the one most commonly used. Compression by Partial Match (PPM) is an adaptive statistical modelling technique that is widely used in the field of text compression. Compression-based approaches are able to build models very efficiently and incrementally. Experiments show that adaptive compressionbased approach for Pinyin input outperforms modified Kneser-Ney smoothing method implemented by SRILM language tools (Stolcke, 2002).
Design of Restaurant Billing System (E Bill Resto) by Applying Synchronization of Data Billing in Branch Companies to Main Companies Based on Rest API (2020)

Culinary business is a business opportunity that is most in-demand, E Bill Resto is a restaurant billing system that was developed by involving several selling places/restaurants with the name of a brand that is connected to the parent company by a database server. With an integrated system, all revenue from restaurant sales can be monitored in realtime. The system design is made by implementing the RESTFul API architecture with security access tokens. The Master Application as a provider of Embedded Data Service Web resources on 3 Restaurant Information Systems, It does the synchronization of 3 Web Service Clients, Data From the Master-Slave Side was obtained by testing 3 data sampling, where both applications are tested QoS (Quality of Service) with 3 new data samples, from the INDOSAT Internet Provider which showed an average test result of Throughput of 170.3 bps, Packet Loss of 18.851% and Delay (latency) of 78.4 ms. Whereas using the TELKOM Internet Provider with an average throughput of 259.5 bps, Packet Loss of 14.28% and delay (latency) of 83.8 ms. Then it can be concluded that testing based on TIPHON Throughput and Delay (latency) from INDOSAT 4G and TELKOM signal Internet Providers showed the category of "Very Good" while the Packet Loss test obtained the "Bad" category.
Inhibitory action of lansoprazole and its analogs against Helicobacter pylori: inhibition of growth is not related to inhibition of urease (1995)

The proton pump inhibitors omeprazole and lansoprazole and its acid-activated derivative AG-2000, which are potent and specific inhibitors of urease of Helicobacter pylori (K. Nagata, H. Satoh, T. Iwahi, T. Shimoyama, and T. Tamura, Antimicrob. Agents Chemother. 37:769-774, 1993), inhibited the growth of H. pylori. The growth was inhibited not only in urease-positive clinical isolates but also in their urease-negative derivatives which had no urease polypeptides. AG-1789, a derivative of lansoprazole with no inhibitory activity against H. pylori urease, also inhibited the growth of both strains even more strongly than the urease inhibitors lansoprazole and AG-2000. Furthermore, the antibacterial activity of omeprazole and lansoprazole was not affected by glutathione or dithiothreitol, which completely abolished the inhibitory activity of lansoprazole against H. pylori urease. These results indicated that the inhibitory action of these compounds against the growth of H. pylori was independent from the inhibitory action against urease.
Tag refinement based on multilingual tag hierarchies extracted from image folksonomy (2017)

This paper presents a novel method for tag refinement using multilingual sources of tagged images in an image folksonomy. The proposed method enables accurate tag refinement by effectively leveraging multilingual sources of tags and considering the hierarchical structure of tags in the following way. First, synonymous tags across different languages are detected based on similarities between tagged images. In this stage, the proposed method utilizes visual similarities to effectively detect synonymous tags since the visual features extracted from images should be similar if they are assigned tags with the same meaning in different languages. Then hierarchical structure of the tags are extracted based on the similarity between the detected synonymous tags. The hierarchical structure provides hypernymous and hyponymous tags of the target tags, which are important for considering the relevance between tags and images. Consulting the hierarchical structure enables removal of irrelevant tags from the images and assignment of relevant tags to the images. The proposed method effectively utilizes tags in various languages in an image folksonomy. Experimental results show the effectiveness of introducing multilingual sources of tagged images for accuracy improvement in tag refinement.