gebhart/patrepeval huggingface dataset:
Novel Approach to CBM+ Implementation on Aviation Systems (2021)

SUMMARY & CONCLUSIONSAs next generation aircraft design evolves, so do the capabilities for predictive and prognostic advancements. These developments have been key to the transition from the traditional reactive maintenance concepts to more proactive strategies. This paradigm shift has fostered an increased readiness of aviation platforms through Condition Based Maintenance Plus (CBM+) constructs as a continuous improvement program. The goal of CBM+ is to leverage efficient processes and procedures coupled with sensing and monitoring technology to predict when failures will occur whilst taking action before a failure can occur to mitigate operational downtime.Introducing CBM+ programs on platforms can be challenging. There can be a degree of difficulty in identifying appropriate CBM+ enablers early in a program lifecycle when establishing maintenance concepts is the most beneficial. This is due to immaturity of the design coupled with the unknowns or unobserved failure modes and system behaviors that drive the evidence of need for this benefit. These challenges are even more evident on aviation programs as there are a multitude of constraints – such as weight, cost, and schedule – that make significant CBM+ constructs more difficult to realize.This case study highlights a new approach for planning a CBM+ program to help alleviate constraints and challenges evident on aviation programs and demonstrate the benefits from such an initiative. The strategy includes a Functional System Modeling approach and tailored gap analysis in concert with unique testing. The gap analysis simplifies the CBM+ selection process whilst ensuring cost, schedule, safety, and reliability are considered. Item specific testing is recommended for early implementation to precipitate failure behaviors and postulate predictors when limited fielded experience is evident. Furthermore, introducing a digital thread is principal to ensure successful implementation of a modern CBM+ development program to facilitate robust information from the platform and visibility into the product life cycle.
High-order subharmonically pumped mixers using phased local oscillators (2006)

A high-order subharmonically pumped mixer architecture that utilizes multiple pairs of antiparallel diodes is described. A key component of the mixer architecture is a K-way power-divider/phase shifter that divides the local oscillator (LO) to multiple ports with equal magnitude and prescribed phase shifts. Undesired mixing products are eliminated through phase cancellation by symmetry rather than relying on intermediate idler circuits. As a proof-of-principle demonstration, an eighth-order mixer is implemented based on this approach and has shown a measured conversion loss of 8 dB at 8 GHz. The mixer architecture is suitable for applications in the millimeter and submillimeter-wave regions where high-frequency LOs are difficult to implement.
Cloning and expression of a member of a new cytochrome P-450 family: cytochrome P-450lin (CYP111) from Pseudomonas incognita (1993)

Cytochrome P-450lin catalyzes the 8-methyl hydroxylation of linalool as the first committed step of its utilization by Pseudomonas incognita as the sole carbon source. By using a polymerase chain reaction-based cloning strategy, a 2.1-kb DNA fragment containing the cytochrome P-450lin gene (linC) was isolated. An open reading frame of 406 amino acids has been identified as that of P-450lin on the basis of amino acid sequence data from peptides of the native protein. Heterologous expression of functional holoprotein is exhibited by Escherichia coli transformed with pUC18 containing the subcloned linC gene under constitutive transcriptional control of the lac promoter. The G+C content of linC was found to be 55% overall and 58% in the third codon position. An optimized amino acid sequence alignment of P-450lin with cytochrome P-450cam shows that the two enzymes have only 25% identity. P-450lin was found to exhibit the expected conservation in the axial cysteine heme ligand-containing peptide and the threonine region postulated to form an O2-binding pocket (T. L. Poulos, B. C. Finzel, and A. J. Howard, J. Mol. Biol. 195:687-700, 1987). The low amino acid sequence identity between P-450lin and all other P-450 sequences has shown that P-450lin is the first member of the CYP111 P-450 gene family.
Synthesis of Diaryl-Substituted Imidazo[1,2-a]pyridines Designed as Potential Aromatase Inhibitors. (2000)

From a pharmacophore model of bicyclic heterocycles as aromatase inhibitors we have designed three series of imidazo[1,2-a]pyridine derivatives. The synthesis and the spectroscopy determination of various compounds are reported. The crystal data of one of these compounds (10b) was obtained. The aromatase inhibition potency was evaluated in vitro and no activity was found.
Liquid-Filled Highly Asymmetric Photonic Crystal Fiber Sagnac Interferometer Temperature Sensor (2020)

In this paper, we theoretically designed and numerically studied a high-resolution and ultrasensitive photonic crystal fiber temperature sensor by selective filling of a liquid with high thermo-optic coefficient in one of the airholes of the fiber. The finite element method was utilized to study the propagation characteristics and the modal birefringence of the fiber under different ambient temperatures. A large base birefringence value of 7.7 × 10−4 as well as a large birefringence sensitivity of almost 29% to a 10 °C temperature variation was achieved for the optimized fiber design with liquid chloroform between 15 °C and 35 °C. We also studied the performance of the proposed optical fiber in a temperature sensing Sagnac interferometer. An average linear temperature sensitivity of 17.53 nm/°C with an average resolution of 5.7 × 10−4 °C was achieved over a temperature range of 20 °C (15 °C to 35 °C).
Performance analysis of mobility-assisted routing (2006)

Traditionally, ad hoc networks have been viewed as a connected graph over which end-to-end routing paths had to be established.Mobility was considered a necessary evil that invalidates paths and needs to be overcome in an intelligent way to allow for seamless ommunication between nodes.However, it has recently been recognized that mobility an be turned into a useful ally, by making nodes carry data around the network instead of transmitting them. This model of routing departs from the traditional paradigm and requires new theoretical tools to model its performance. A mobility-assisted protocol forwards data only when appropriate relays encounter each other, and thus the time between such encounters, called hitting or meeting time, is of high importance.In this paper, we derive accurate closed form expressions for the expected encounter time between different nodes, under ommonly used mobility models. We also propose a mobility model that can successfully capture some important real-world mobility haracteristics, often ignored in popular mobility models, and alculate hitting times for this model as well. Finally, we integrate this results with a general theoretical framework that can be used to analyze the performance of mobility-assisted routing schemes. We demonstrate that derivative results oncerning the delay of various routing s hemes are very accurate, under all the mobility models examined. Hence, this work helps in better under-standing the performance of various approaches in different settings, and an facilitate the design of new, improved protocols.
A mouse atlas of gene expression: Large-scale digital gene-expression profiles from precisely defined developing C57BL/6J mouse tissues and cells (2005)

We analyzed 8.55 million LongSAGE tags generated from 72 libraries. Each LongSAGE library was prepared from a different mouse tissue. Analysis of the data revealed extensive overlap with existing gene data sets and evidence for the existence of approximately 24,000 previously undescribed genomic loci. The visual cortex, pancreas, mammary gland, preimplantation embryo, and placenta contain the largest number of differentially expressed transcripts, 25% of which are previously undescribed loci.
Approximation Algorithms for Partial Vertex Covers in Trees (2023)

This paper is concerned with designing algorithms for and analyzing the computational complexity of the partial vertex cover problem in trees. Graphs (and trees) are frequently used to model risk management in various systems. In particular, Caskurlu et al. in [4] have considered a system which essentially represents a tripartite graph. The goal in this model is to reduce the risk in the system below a predefined risk threshold level. It can be shown that the main goal in this risk management system can be formulated as a Partial Vertex Cover problem on bipartite graphs. In this paper, we focus on a special case of the partial vertex cover problem, when the input graph is a tree. We consider four possible versions of this setting, depending on whether or not, the vertices and edges are weighted. Two of these versions, where edges are assumed to be unweighted, are known to be polynomial-time solvable. However, the computational complexity of this problem with weighted edges, and possibly with weighted vertices, remained open. The main contribution of this paper is to resolve these questions by fully characterizing which variants of partial vertex cover remain NP-hard in trees, and which can be solved in polynomial time. In the paper, we propose two pseudo-polynomial DP-based algorithms for the most general case in which weights are present on both the edges and the vertices of the tree. One of these algorithms leads to a polynomial-time procedure, when weights are confined to the edges of the tree. The insights used in this algorithm are combined with additional scaling ideas to derive an FPTAS for the general case. A secondary contribution of this work is to propose a novel way of using centroid decompositions in trees, which could be useful in other settings as well.
Arrhythmogenicity of fibro-fatty infiltrations (2018)

The onset of cardiac arrhythmias depends on electrophysiological and structural properties of cardiac tissue. One of the most important changes leading to arrhythmias is characterised by the presence of a large number of non-excitable cells in the heart, of which the most well-known example is fibrosis. Recently, adipose tissue was put forward as another similar factor contributing to cardiac arrhythmias. Adipocytes infiltrate into cardiac tissue and produce in-excitable obstacles that interfere with myocardial conduction. However, adipose infiltrates have a different spatial texture than fibrosis. Over the course of time, adipose tissue also remodels into fibrotic tissue. In this paper we investigate the arrhythmogenic mechanisms resulting from the presence of adipose tissue in the heart using computer modelling. We use the TP06 model for human ventricular cells and study how the size and percentage of adipose infiltrates affects basic properties of wave propagation and the onset of arrhythmias under high frequency pacing in a 2D model for cardiac tissue. We show that although presence of adipose infiltrates can result in the onset of cardiac arrhythmias, its impact is less than that of fibrosis. We quantify this process and discuss how the remodelling of adipose infiltrates affects arrhythmia onset.
Lactate: Brain Fuel in Human Traumatic Brain Injury: A Comparison with Normal Healthy Control Subjects (2015)

We evaluated the hypothesis that lactate shuttling helps support the nutritive needs of injured brains. To that end, we utilized dual isotope tracer [6,6-(2)H2]glucose, that is, D2-glucose, and [3-(13)C]lactate techniques involving arm vein tracer infusion along with simultaneous cerebral (arterial [art] and jugular bulb [JB]) blood sampling. Traumatic brain injury (TBI) patients with nonpenetrating brain injuries (n=12) were entered into the study following consent of patients' legal representatives. Written and informed consent was obtained from control volunteers (n=6). Patients were studied 5.7±2.2 (mean±SD) days post-injury; during periods when arterial glucose concentration tended to be higher in TBI patients. As in previous investigations, the cerebral metabolic rate for glucose (CMRgluc, i.e., net glucose uptake) was significantly suppressed following TBI (p<0.001). However, lactate fractional extraction, an index of cerebral lactate uptake related to systemic lactate supply, approximated 11% in both healthy control subjects and TBI patients. Further, neither the CMR for lactate (CMRlac, i.e., net lactate release), nor the tracer-measured cerebral lactate uptake differed between healthy controls and TBI patients. The percentages of lactate tracer taken up and released as (13)CO2 into the JB accounted for 92% and 91% for control and TBI conditions, respectively, suggesting that most cerebral lactate uptake was oxidized following TBI. Comparisons of isotopic enrichments of lactate oxidation from infused [3-(13)C]lactate tracer and (13)C-glucose produced during hepatic and renal gluconeogenesis (GNG) showed that 75-80% of (13)CO2 released into the JB was from lactate and that the remainder was from the oxidation of glucose secondarily labeled from lactate. Hence, either directly as lactate uptake, or indirectly via GNG, peripheral lactate production accounted for ∼70% of carbohydrate (direct lactate uptake+uptake of glucose from lactate) consumed by the injured brain. Undiminished cerebral lactate fractional extraction and uptake suggest that arterial lactate supplementation may be used to compensate for decreased CMRgluc following TBI.
Medical Image Fusion via an Effective Wavelet-Based Approach (2010)

A novel wavelet-based approach for medical image fusion is presented, which is developed by taking into not only account the characteristics of human visual system (HVS) but also the physical meaning of the wavelet coefficients. After the medical images to be fused are decomposed by the wavelet transform, different-fusion schemes for combining the coefficients are proposed: coefficients in low-frequency band are selected with a visibility-based scheme, and coefficients in high-frequency bands are selected with a variance based method. To overcome the presence of noise and guarantee the homogeneity of the fused image, all the coefficients are subsequently performed by a window-based consistency verification process. The fused image is finally constructed by the inverse wavelet transform with all composite coefficients. To quantitatively evaluate and prove the performance of the proposed method, series of experiments and comparisons with some existing fusion methods are carried out in the paper. Experimental results on simulated and real medical images indicate that the proposed method is effective and can get satisfactory fusion results.
Environmental Scanning Electron Microscopy of Dermal Fibroblasts on Various Types of Polymer Scaffolds (2020)

With the progress in tissue engineering, the need for deep understanding of the interaction between individual cells and cellular systems with biocompatible polymer scaffolds has become obvious. This requires data on the adhesion and proliferation of cells on the scaffolds. Environmental scanning electron microscopy makes it possible to increase the pressure and humidity in a microscope chamber, thereby bringing the experimental conditions close to environmental. Scanning electron microscopy study of dermal fibroblasts is illustrated by the example of several scaffolds of different morphologies, including sponges, films, and nonwoven materials based on poly(L-)lactide, polycaprolactone, and a poly(L-)lactide-co-polycaprolactone. The data obtained show that the proposed method is promising for studying cell structures on polymer scaffolds.
Six standard panels for hepatoviral diagnosis. (1995)

From the many available tests for hepatoviral diagnosis the most reliable and established were incorporated into a series of panels. Six groups or batteries of tests are proposed, each directed to one clinical question. These are hepatitis B detection and chronic hepatitis B monitoring, hepatitis detection and chronic hepatitis monitoring, as well as a hepatitis and chronic hepatitis monitoring, as well as a hepatitis screening panel for blood banks and an immune status panel to determine individual immune status and risk. This approach limits the number of immuno-diagnostic tests needed and simplifies laboratory workflow. The limitations, including specificity problems encountered with tests based on the polymerase chain reaction (PCR), and probable future developments of tests excluded from the simplified panel concept are discussed.
Human Rhinovirus Induced Cytokine/Chemokine Responses in Human Airway Epithelial and Immune Cells (2014)

Infections with human rhinovirus (HRV) are commonly associated with acute upper and lower respiratory tract disease and asthma exacerbations. The role that HRVs play in these diseases suggests it is important to understand host-specific or virus-specific factors that contribute to pathogenesis. Since species A HRVs are often associated with more serious HRV disease than species B HRVs, differences in immune responses they induce should inform disease pathogenesis. To identify species differences in induced responses, we evaluated 3 species A viruses, HRV 25, 31 and 36 and 3 species B viruses, HRV 4, 35 and 48 by exposing human PBMCs to HRV infected Calu-3 cells. To evaluate the potential effect of memory induced by previous HRV infection on study responses, we tested cord blood mononuclear cells that should be HRV naïve. There were HRV-associated increases (significant increase compared to mock-infected cells) for one or more HRVs for IP-10 and IL-15 that was unaffected by addition of PBMCs, for MIP-1α, MIP-1β, IFN-α, and HGF only with addition of PBMCs, and for ENA-78 only without addition of PBMCs. All three species B HRVs induced higher levels, compared to A HRVs, of MIP-1α and MIP-1β with PBMCs and ENA-78 without PBMCs. In contrast, addition of CBMCs had less effect and did not induce MIP-1α, MIP-1β, or IFN-α nor block ENA-78 production. Addition of CBMCs did, however, increase IP-10 levels for HRV 35 and HRV 36 infection. The presence of an effect with PBMCs and no effect with CBMCs for some responses suggest differences between the two types of cells possibly because of the presence of HRV memory responses in PBMCs and not CBMCs or limited response capacity for the immature CBMCs relative to PBMCs. Thus, our results indicate that different HRV strains can induce different patterns of cytokines and chemokines; some of these differences may be due to differences in memory responses induced by past HRV infections, and other differences related to virus factors that can inform disease pathogenesis.
Extraction of Food-Related Onomatopoeia from Food Reviews and its Application to Restaurant Search (2014)

Onomatopoeia has been widely used recently in food reviews about food or restaurants. In this paper, we propose and evaluate a method to automatically extract onomatopoeia including unknown ones from food reviews sites. From the evaluation result, we found that it is able to extract onomatopoeia for specific foods with more than 46% precision; the method found 18 new unknown food-related onomatopoeias, i.e., not registered in an existing onomatopoeia dictionary, and in 62 extracted onomatopoeias. In addition, we propose a system that can present the user with a list of onomatopoeia specific to a restaurant she/he is interested in. The evaluation results indicate that an intuitive restaurant search can be done via a list of onomatopoeia, and that they are helpful for selecting food or restaurants.
Lipid Hydroperoxide Determination in Dark Chicken Meat through a Ferrous Oxidation−Xylenol Orange Method (2000)

A ferrous oxidation-xylenol orange (FOX) method was adapted to measure lipid hydroperoxides (LHP) in raw and cooked dark chicken meat. Its applicability was evaluated using samples with different alpha-tocopherol contents or unsaturation degrees (both modulated by dietary supplementation). The FOX assay can work as an induced method because there is some oxidation of the sample extract during the incubation of the reaction. Consequently, it allows assessment of sample susceptibility to oxidation (response after some hours of incubation) and comparison of samples that are highly oxidized or readily susceptible to oxidation through their absorbance after 30 min of incubation. It is highly specific for LHP and showed a linear relationship between volume of meat extract and absorbance. However, the most suitable volume of extract and incubation time must be studied for each kind of sample. The use of butylated hydroxytoluene during this incubation is strongly discouraged because it attenuated the reaction by radical stabilization, thus diminishing Fe(III) formation and leading to a lower response.
Mucosal Protective Compounds in the Treatment of Gastroesophageal Reflux Disease. A Position Paper Based on Evidence of the Romanian Society of Neurogastroenterology (2016)

Drugs used to protect the esophageal mucosa against acid are useful in alleviating chronic heartburn, especially in patients with mild reflux symptoms.
Inhibition of oncornavirus functions by poly (2-methylthioinosinic acid) (1975)

Poly (2-methylthioinosinic acid) [poly(ms2I)] was found to markedly inhibit the RNA directed DNA polymerase (reverse transcriptase) activity of murine (Moloney, Rauscher) leukemia virus and murine (Moloney) sarcoma virus, while under the same conditions the unsubstituted parent compound poly(I) showed little, if any, inhibitory effect. Copolymers of inosinic acid (I) and 2-methylthioinosinic acid2(ms2I) showed an intermediary effect, depending on the I:ms2I ratio. Poly(ms2I) also inhibited the transformation of normal cells by murine (Moloney) sarcoma virus, as assessed by an infectious center assay.
Changes in body weight after 24 weeks of vildagliptin therapy as a function of fasting glucose levels in patients with type 2 diabetes (2014)

The present analysis showed that treatment with vildagliptin results in a negative caloric balance when glucose levels are below the renal threshold at baseline.
ChemInform Abstract: Site Isolated Base and Acid Catalyzed Azaspirocyclization Cascades. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.