gebhart/patrepeval huggingface dataset:
A novel twin-ridge-waveguide optical amplifier switch (1992)

A novel twin ridge-waveguide optical amplifier switch is reported. The technique of hydrogen passivation of acceptors has been applied to decrease the current spreading in the region between the ridges. The incorporation of a passive waveguide below the active waveguide leads to the result that using 1.53 mu m TE polarized light, through and cross states, each with only 1 dB insertion loss, fiber-to-fiber, can be selected in a device of 360 mu m length by varying the currents to each ridge with a total current of 140 mA. A minimum crosstalk of less than -33 dB was achieved when the cross state was selected. This is the first report of a twin ridge-waveguide amplifier switch with such a low-loss, low-polarization sensitivity, and low crosstalk.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Supported Palladium Nanoparticles: An Efficient Catalyst for the Direct Formation of H2O2 from H2 and O2 (2008)

Ex situ synthesis is the key: Palladium nanoparticles having a narrow size distribution around 3.6 nm have been synthesized in a liquid phase and then loaded onto a carbon support with an overall efficiency of 85 %. The resulting nanoparticles, which retained their size and morphology, were exceptionally active and selective as a catalyst for the direct formation of H2O2 from H2 and O2 in ethanol. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z801517_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
High energy, high pulse rate laser operation using crystalline adhesive-free bonded Yb:YAG slabs (2023)

We report on the successful amplification of 10 ns pulses to 10 J energy at 10 Hz in a DiPOLE laser amplifier using crystalline Yb:YAG/Cr:YAG composite slabs manufactured using adhesive-free bonding (AFB) technology. We demonstrate that bonded slabs are suitable for operation in high energy cryogenic laser amplifiers. We also report on frequency doubling of the beam amplified in the bonded slabs. When the pulse energy of the output infrared beam is set to 5 J, a pulse energy of 3.9 J is achieved in the green (corresponding to 78% conversion efficiency). Results demonstrate that AFB technology is suitable for producing large-sized gain material slabs and can overcome current limitations in the manufacture of large-aperture gain material pieces. We believe this work will facilitate energy scaling of high energy lasers where aperture scaling of optical elements is not achievable via conventional manufacturing techniques.
Crystal structure of the usher:chaperone:adhesin subunit complex – insights into pilus assembly mechanism (2011)

Activation of the complement cascade involves multiple proteolytic reactions mediated by large macromolecular complexes.Upon initiation, the three complement pathways converge into the critical step of the conversion of C3 to its activated form C3b by means of short-lived enzymatic complexes called C3 convertases.These convertases amplify C3b production near target surfaces, resulting in opsonization of target cells, activation of the complement terminal pathway and stimulation of the adaptive immune response.Generation and activation of complement convertases are multi-step processes that require localization of serine protease-containing proenzymes on large protein subunits.The interplay between formation of large multi-domain enzymes, extensive conformational changes and specific proteolytic cleavages highlights the complexity of the complement system.We investigated the process of convertase formation in the alternative pathway of complement.In this pathway, the C3 convertase complex is generated when the proenzyme factor B (FB) interacts with surface-bound C3b to form the pro-convertase C3bB, which is then specifically cleaved by the soluble, self-inactivated serine protease factor D (FD), yielding the active yet unstable C3 convertase C3bBb.We present here the crystal structures of the pro-convertase complex C3bB, formed by C3b (12 domains, 160 kDa) with factor B (5 domains, 90 kDa) at 4-Å resolution and the transient complex formed by C3bB with an inactive mutant of factor D (1 domain, 27 kDa) at 3.5-Å resolution.In agreement with previously published electron microscopy data, our structures highlight the equilibrium between an initial (closed/loading) state and a subsequent (open/activation) state of factor B. The structures reveal unexpected conformational changes that create the "open" state which exposes the scissile loop of FB for proteolytic cleavage.In the C3bBD * complex, we show how the open state of FB provides a docking platform for factor D distant from its catalytic site, which has been caught in an activated conformation.Additional biochemical and biophysical analyses confirm the observed structural features and reveal a highly concerted and specific activation mechanism based on cofactor-dependent and substrateinduced proteolysis, which provides an important "double-safety" catch to restrict complement amplification to C3b-tagged target cells.By adding new frames to the "structural movie" of complement activation, our data also provide new valuable information for potential structurebased drug design of complement inhibitors.
Application of capillary electrophoresis and high performance liquid chromatography in the study of polyoxometalate complexes (2014)

Polyoxometalate complexes are investigated by the separation methods of capillary electrophoresis and ionpair high-performance liquid chromatography (HPLC) using as an example the separation of model mixtures of heteropolytungstates and actual mixtures of heteropolymolybdate synthesis products of various compositions. The capabilities of the methods to separate complexes with similar structures and compositions are shown, provided that the separation conditions are optimized. For electrophoretic separation, there is a possibility of increasing the resolution of the signals by modifying the inner surface of the capillary.
Description of the goose coccidium Eimeria stigmosa (Klimes, 1963), with evidence of intranuclear development. (1986)

Oocysts of Eimeria stigmosa isolated from a wild juvenile lesser snow goose (Anser caerulescens caerulescens) were used in experimental infections of laboratory-reared geese. The structure of oocysts is described; a peculiar bumpy surface and a calyx-like thickening around the micropyle are illustrated by scanning electron microscopy. Experimentally infected geese had reduced feed intake and passed blood in their feces. Six days post-inoculation (p.i.) oocysts were passed for about 24 hr. Oocyst production was not increased in dexamethasone-treated geese. Complete sporulation of oocysts occurred after about 3.5 days. Developmental stages in lesser snow geese were occasionally present throughout the intestine, but were concentrated at Meckel's diverticulum, and at foci in the ileum and colon. Meronts were found 2, 3 and 4 days p.i. and gamonts and developing oocysts were observed 4, 5 and 5.5 days p.i. All endogenous stages of E. stigmosa were present in the nucleoplasm of enterocytes, primarily at the apical half of villi. Nuclear hypertrophy occurred in infected cells and nuclei containing gamonts were enlarged up to 4 times their normal size. Mild lesions were observed in the intestine of infected geese. Patent infections were established in lesser snow, Canada (Branta canadensis) and domestic (Anser anser domesticus) geese, but oocysts were not passed by inoculated ducks.
A phase Ib study of pertuzumab (P), a recombinant humanized antibody to HER2, and docetaxel (D) in patients (pts) with advanced solid tumors (2005)

3166 Background: P represents the first in a new class of targeted therapeutics known as HER dimerization inhibitors (HDIs). It blocks ligand-associated heterodimerization of HER2 with other HER-kinase family members, thereby inhibiting intracellular signaling. Study endpoints: determine the maximum tolerated dose (MTD) and the dose limiting toxicities (DLTs) of P and D, and the pharmacokinetic (PK) interaction. Methods: DLTs are assessed in cycle 1 and defined as non-hematological toxicity ≥ grade 3, grade 4 neutropenia of > 7 days, thrombocytopenia grade 4. If DLT is observed in ≥ 2/6 pts at a dose level, MTD is exceeded. Pts are treated with a fixed dose of 1050 mg of P and an escalating dose of D as an IV infusion on day 1, q 3 weeks. Three dose levels of D are explored: 60, 75, and 100 mg/ m2. Results: To date, a total of 8 pts (6 males) have received 36 cycles, median 5 (range 1–9). Mean age: 59.5 years, PS 0/1: 5/3 pts. Tumor types: prostate (4), ovarian (2), head & neck (1) and melanoma (1). At dose level D 75 mg/ m2, 2 pts developed DLTs: grade 3 diarrhea and fatigue, and febrile neutropenia, respectively. None of 6 pts treated at dose level 1 developed DLTs. Most frequent grade 1/2 toxicities per cycle included: diarrhea 36% (grade 3 6%), fatigue 31% (grade 3 6%), mucositis 17%, and nausea 8%. Neutropenia and leukopenia grade 3/4 occurred in 28% and 19% of cycles, respectively. Preliminary data from 8 pts suggest that PK parameters of D are not altered in combination with P. Mean clearance of D single agent versus D combined with P is 59 L/h ± 14 and 68 L/h ± 16, respectively. Tumor assessment: 1 PR, 5 SD and 1 progression. Conclusions: The RP2D will be 60 mg/m2 D and 1050 mg of P but further evaluation of D at 75 mg/m2 and P at 420 mg (840 mg loading dose) q 3 weeks is ongoing. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Hoffmann-La Roche Ltd., Hoffmann-La Roche Boehringer Ingelheim, Celgene, Novartis, Oncolytics Biotech, Topotargets Hoffmann-La Roche, GlaxoSmithKline Hoffmann-La Roche, Novartis, Quintiles Oncology
Etiology and Clinical Patterns of Uveitis at Three Ophthalmic Clinics in Tajikistan (2019)

A prospective observational study was conducted at three ophthalmic clinics to assess the clinical patterns and etiology of uveitis in the Central Asia Republic of Tajikistan. All patients underwent physical and ophthalmologic examinations. Extensive efforts were made to determine the etiology of uveitis, including workups for Behçet's Disease (BD) and Vogt–Koyanagi–Harada (VKH) syndrome. All patients were tested for the presence of HLA-B27. Presence and/or history of tuberculosis and syphilis were ruled out. HSV, CMV, Chlamydia trachomatis and HIV antibody titers were determined by ELISA. Uveitis was diagnosed in 51 patient ages 14 to 60 were with women accounted for 60.8%. Bilateral uveitis was presented in 74.5% cases and dominated in all age groups. Seven HLA-B27-positive patients had isolated uveitis without systemic manifestations and five had uveitis associated with spondyloarthritis (SpA). In total, uveitis was associated most commonly with SpA (23.5%), BD (9.8%), and VKH syndrome (5.9%). In 41.2% of uveitis cases, etiology was unknown. Conclusions: The overall clinical patterns and etiology of uveitis in Tajikistan are comparable to those reported from outside the Central Asia region. Bilateral uveitis dominated in all age groups with HLA-B27-positive uveitis present in 23.5% of patients and more common in men.
An efficient high-speed block turbo code decoding algorithm and hardware architecture design (2004)

We propose a high speed block turbo code decoding algorithm and design hardware architecture. Block turbo codes (BTCs) support variable code rates and packet sizes, and show a high-performance owing to a soft decision iterative decoding of turbo codes. However, BTCs have a long decoding time because of an iterative decoding and complicated extrinsic information operation. The proposed algorithm, using the threshold that represents channel information, reduces the long decoding time. The threshold is decided by the absolute mean and the standard deviation of an LLR (log likelihood ratio) in consideration that the LLR distribution is Gaussian. As a result of logic synthesis using 0.35 /spl mu/m CMOS technology, it is proved that the decoder applied by the proposed algorithm reduces the decoding time by about 30% and includes about 20K logic gates and 32 Kbit memory size.
ELECTRIC EQUIPMENT OF THE THREE-PHASE LOCOMOTIVE TYPE 120 OF THE WEST GERMAN RAILROAD SYSTEM (1979)

The tight weight and space restrictions for the electric equipment of the class 120, due to the continuous load of 5. 6 Mw, imposed high requirements on the design of various components of the main circuit. A description is given of the design of these components such as transformers, four-quadrant controller and inverter. The electronic control of the locomotive is explained.
Conidia of one Fusarium solani isolate from a soybean-production field enable to be virulent to soybean and make soybean seedlings wilted (2018)

Fusarium is usually thought to cause soybean root rot, which results in a large quantity of annual yield loss in soybean production, by its secretions including Fusarium toxins and cell wall degrading enzymes, but not by the conidia themselves that do not underlie any virulence so far. Here we report that the conidia of one Fusarium solani isolate are able to be virulent to soybean and make soybean seedlings wilted alone. We isolated them from the wilted plants in a soybean-production field and molecularly identified 17 Fusarium isolates through phylogenetic analysis. Of them, except for one isolate that showed diversity of virulence to different soybeans (virulent to one soybean whereas avirulent to another soybean), the others were all virulent to the two tested soybeans: both conidia cultures and secretions could make soybean seedlings wilted at 5 days post infection, and their virulence had dosage effects that only conidia cultures of at least 5×106 conidia mL–1 could show virulence to soybean; however, the sole conidia of the F. solani isolate #4 also exhibited virulence to soybean and could make soybean seedlings wilted. Finally, we developed the specific cleaved amplified polymorphic sequences (CAPS) markers to easily differentiate Fusarium isolates. The isolate #4 in this work will likely be used to investigate the new mechanism of virulence of Fusarium to soybean.
Primer sequences from Platelet-Specific PDGFB Ablation Impairs Tumor Vessel Integrity and Promotes Metastasis (2023)

&lt;p&gt;Supplementary methods: Primer sequences&lt;/p&gt;
Properties of Conducting Polymer-Dye Composite and Photovoltaic Characteristics of Junction Devices (2000)

We have prepared new soluble conducting polymer/dye composite and photovoltaic cells with three different architectures using soluble conducting polymer (CP) as hole transport material and perylene derivatives (PV) as electron transport material. These architectures comprise single-layer (ITO/CP-PV/Al) and double-layer (ITO/CP-PV/PV/Al) as well as three-layer (ITO/CP-C 60 /CP-PV/PV/Al) structures. Electrical and optical properties of soluble conducting polymer composite film and current-voltage characteristics and photocurrent spectra of photovoltaic cells are discussed. The results show that the soluble conducting polymer-dye composite represents a new class of organic semiconducting material that can be used to manufacture photovoltaic cells.
Stimulating Cortical Drift for Non-Invasive and Efficient Treatment of a Skeletal Class III Patient (2021)

Sutures and condyles are very important biological targets during orthopedic treatment of facial deformities. However, less understood is cortical drift, another natural phenomenon that if properly stimulated can play a significant role in correction of facial deformities. This phenomenon can be stimulated locally with well-planned mechanotherapy, especially free-object designs such as one-couple system. Here we present, a successful treatment of a severe skeletal Class III patient using cortical drift as an important component of a customized Neuro-Immuno-Mechanotherapy (NIM). During this non-invasive treatment approach, significant correction of the Class III jaw relation was achieved through maxillary advancement without surgery or extractions. The patient did not report any side effects or discomfort related to this treatment. This case study demonstrates the importance of using innovative approaches combining proper stimulation of the biological response with a customized mechanotherapy for treatment of severe craniofacial deformities.
Morphology, ion impact, and kinetic parameters of swift heavy-ion-induced Y2O3:Dy3+ phosphor (2013)

This paper reports the morphology, ion impact, and kinetic parameters of Y2O3:Dy3+ phosphor induced by 150-MeV Ni7+, 120-MeV Ag9+, and 110-MeV Au8+ swift heavy ions (SHIs) in the fluence range 1 × 1011–1 × 1013 ions cm−2. The X-ray diffraction (XRD), transmission electron microscope (TEM), and Fourier transform infrared (FTIR) studies confirm the loss of crystallinity of ion-irradiated phosphors. Thermoluminescence (TL) glow curves of ion-irradiated phosphors show a small shift in the position of peaks, along with an increase in intensity with ion fluence. Stopping and range of ions in matter (SRIM) calculations were performed in order to correlate the change in TL properties of ion-irradiated Y2O3:Dy3+ phosphors. The ion impact parameters show that the defect created by 110-MeV Au8+ ions is greater in number. Kinetic parameters were calculated from TL data using a computerized glow-curve deconvolution (CGCD) method.
Practical extension to CIELUV color space to improve uniformity (2003)

A uniform chromaticity scale (UCS) in terms of just-noticeable difference (JND) to the human eye is important in industry and image processing, as well as for visually lossless image coding and noise evaluations. CIELUV which aims at microscopic uniformity to human perception, is widely used in color representation. However, its uniformity needs further improvements. In this paper, we demonstrate that a simple modification to CIELUV can further improve uniformity. Firstly, we optimized the CIELUV coefficient set while preserving its formulation to improve uniformity. This improved uniformity by 24%. Secondly, we slightly modified the formulation and obtained an optimized coefficient set. This improved uniformity by another 38%. Thirdly, we further optimized specifically inside the sRGB gamut, since the use of color contents conforming to the sRGB standard is ever increasing. This improved uniformity by yet another 3-5%.
To what does the harmonic series converge? (2013)

We consider what value the harmonic series will converge to if evaluated in the obvious way using some standard computational arithmetic types.
Economic evaluation of chronic lymphocytic leukemia from a hospital management perspective (2016)

In our research-driven tertiary care hospital, inpatient treatment of patients with CLL is not cost covering. This analysis demonstrates the need for novel care/reimbursement structures in CLL. From a hospital management perspective, cost revenue controlling is crucial to avoid major economic risks.
Synthesis and characterization of masked aminopyrazolecarboxylic acid synthons (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and characterization of masked aminopyrazolecarboxylic acid synthonsHo H. Lee, Bruce F. Cain, William A. Denny, John S. Buckleton, and George R. ClarkCite this: J. Org. Chem. 1989, 54, 2, 428–431Publication Date (Print):January 1, 1989Publication History Published online1 May 2002Published inissue 1 January 1989https://pubs.acs.org/doi/10.1021/jo00263a032https://doi.org/10.1021/jo00263a032research-articleACS PublicationsRequest reuse permissionsArticle Views1916Altmetric-Citations43LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Histologische Veränderungen des denervierten Kaninchen-Skelettmuskels bei Funktionier Elektrostimulation (1986)

Article Histologische Veränderungen des denervierten Kaninchen-Skelettmuskels bei Funktionier Elektrostimulation was published on January 1, 1986 in the journal Biomedical Engineering / Biomedizinische Technik (volume 31, issue s1).
Development of a Multivalent Subunit Vaccine against Tularemia Using Tobacco Mosaic Virus (TMV) Based Delivery System (2015)

Francisella tularensis is a facultative intracellular pathogen, and is the causative agent of a fatal human disease known as tularemia. F. tularensis is classified as a Category A Biothreat agent by the CDC based on its use in bioweapon programs by several countries in the past and its potential to be used as an agent of bioterrorism. No licensed vaccine is currently available for prevention of tularemia. In this study, we used a novel approach for development of a multivalent subunit vaccine against tularemia by using an efficient tobacco mosaic virus (TMV) based delivery platform. The multivalent subunit vaccine was formulated to contain a combination of F. tularensis protective antigens: OmpA-like protein (OmpA), chaperone protein DnaK and lipoprotein Tul4 from the highly virulent F. tularensis SchuS4 strain. Two different vaccine formulations and immunization schedules were used. The immunized mice were challenged with lethal (10xLD100) doses of F. tularensis LVS on day 28 of the primary immunization and observed daily for morbidity and mortality. Results from this study demonstrate that TMV can be used as a carrier for effective delivery of multiple F. tularensis antigens. TMV-conjugate vaccine formulations are safe and multiple doses can be administered without causing any adverse reactions in immunized mice. Immunization with TMV-conjugated F. tularensis proteins induced a strong humoral immune response and protected mice against respiratory challenges with very high doses of F. tularensis LVS. This study provides a proof-of-concept that TMV can serve as a suitable platform for simultaneous delivery of multiple protective antigens of F. tularensis. Refinement of vaccine formulations coupled with TMV-targeting strategies developed in this study will provide a platform for development of an effective tularemia subunit vaccine as well as a vaccination approach that may broadly be applicable to many other bacterial pathogens.
ChemInform Abstract: Stereocontrol in Horner‐Wadsworth‐Emmons Condensations of α‐ Phosphono Lactones with Aldehydes: A Synthesis of Integerrinecic Acid and Senecic Acid Lactones. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.