gebhart/patrepeval huggingface dataset:
Immunological Probes into the Mechanism of Cholera Toxin action (1976)

The use of antibodies to specific cell surface proteins or to ligands which interact with cell surface receptors is a powerful tool for analyzing the properties of membrane proteins and the consequences of specific cell surface ligand-receptor interactions. Two central observations concerning membrane structure and function, - the diffusibility of membrane proteins (1) and ligand-triggered modulation of specific receptors (2), have derived from the use of antibodies to analyze the properties of membrane proteins. In our study of the mechanism of action of cholera toxin, a protein which binds to a specific cell surface receptor and results in the activation of adenyl cyclase, considerable information has been gained through the use of immunological techniques. This review will briefly summarize the data underlying our current concept of cholera toxin action at the cell membrane and will emphasize those observations made through the use of immunological approaches.
Estimation of residual stresses from elastic recovery of nanoindentation (2006)

In this study, an empirical model based on finite element simulations is presented for residual stress determination from the elastic recovery of nanoindentation. Finite element simulations show that the ratio of elastic recovery of nanoindentation to the maximum penetration depth, h e /h max, has a linear relationship to the ratio of residual stress to yield stress, σ r/σy , and increases for compressive residual stress, whereas it decreases for tensile stress. Nanoindentation tests performed on a bent fused quartz beam in this study, and on diamond-like carbon (DLC) and Au coatings in the literature, also confirm the existence of residual stress effects on the elastic recovery of nanoindentation. The empirical model has been used to derive the plastic properties and to estimate the residual stress of the mechanically polished fused quartz beam.
LightCycler-Based Quantitative PCR for Detection of Cytomegalovirus in Blood, Urine, and Respiratory Samples (2001)

In response to a recently published article by Schaade et al. ([12][1]) describing the value of LightCycler technology for quantitative analysis of cytomegalovirus (CMV) in clinical material, we wish to add our experience. Using a different LightCycler (LC; Idaho Technology Inc., Idaho Falls, Idaho
Up‐Regulation of Immunolabeled α2A‐Adrenoceptors,Gi Coupling Proteins, and Regulatory Receptor Kinases in the Prefrontal Cortex of Depressed Suicides (1999)

Suicide and depression are associated with an increased density of alpha2-adrenoceptors (radioligand receptor binding) in specific regions of the human brain. The function of these inhibitory receptors involves various regulatory proteins (Gi coupling proteins and G protein-coupled receptor kinases, GRKs), which work in concert with the receptors. In this study we quantitated in parallel the levels of immunolabeled alpha2A-adrenoceptors and associated regulatory proteins in brains of suicide and depressed suicide victims. Specimens of the prefrontal cortex (Brodmann area 9) were collected from 51 suicide victims and 31 control subjects. Levels of alpha2A-adrenoceptors, Galphai1/2 proteins, and GRK 2/3 were assessed by immunoblotting techniques by using specific polyclonal antisera and the immunoreactive proteins were quantitated by densitometry. Increased levels of alpha2A-adrenoceptors (31-40%), Galphai1/2 proteins (42-63%), and membrane-associated GRK 2/3 (24-32%) were found in the prefrontal cortex of suicide victims and antidepressant-free depressed suicide victims. There were significant correlations between the levels of GRK 2/3 (dependent variable) and those of alpha2A-adrenoceptors and Galphai1/2 proteins (independent variables) in the same brain samples of suicide victims (r = 0.56, p = 0.008) and depressed suicide victims (r = 0.54, p = 0.041). Antemortem antidepressant treatment was associated with a significant reduction in the levels of Galphai1/2 proteins (32%), but with modest decreases in the levels of alpha2A-adrenoceptors (6%) and GRK 2/3 (18%) in brains of depressed suicide victims. The increased levels in concert of alpha2A-adrenoceptors, Galphai1/2 proteins, and GRK 2/3 in brains of depressed suicide victims support the existence of supersensitive alpha2A-adrenoceptors in subjects with major depression.
The Novel Conjugative Transposon Tn 1207.3 Carries the Macrolide Efflux Gene mef (A) in Streptococcus pyogenes (2003)

The macrolide efflux gene mef(A) of the Streptococcus pyogenes clinical strain 2812A was found to be carried by a 52-kb chromosomal genetic element that could be transferred by conjugation to the chromosome of other streptococcal species. The characteristics of this genetic element are typical of conjugative transposons and was named Tn1207.3. The size of Tn1207.3 was established by pulsed-field gel electrophoresis (PFGE), and DNA sequencing analysis showed that the 7,244 bp at the left end of Tn1207.3 were identical to those of the pneumococcal Tn1207.1 element. Tn1207.3-like genetic elements were found to be inserted at a single specific chromosomal site in 12 different clinical isolates S. pyogenes exhibiting the M phenotype of resistance to macrolides and carrying the mef(A) gene. Tn1207.3 was transferred from S. pyogenes 2812A to Streptococcus pneumoniae, and sequence analysis carried out on six independent transconjugants showed that insertion of Tn1207.3 in the pneumococcal genome always occurred at a single specific site as in Tn1207.1. Using MF2, a representative S. pneumoniae transconjugant, as a donor, Tn1207.3 was transferred again by conjugation to S. pyogenes and Streptococcus gordonii. The previously described nonconjugative element Tn1207.1 of S. pneumoniae appears to be a defective element, part of a longer conjugative transposon that carries mef(A) and is found in clinical isolates of S. pyogenes.
Genetic vasectomy—Overexpression of Prm1‐EGFP fusion protein in elongating spermatids causes dominant male sterility in mice (2010)

Transgenic mice are vital tools in both basic and applied research. Unfortunately, the transgenesis process as well as many other assisted reproductive techniques involving embryo transfer rely on vasectomized males to induce pseudopregnancy in surrogate mothers. Vasectomy is a surgical procedure associated with moderate pain and must be carried out under full anaesthesia by qualified personnel. Eliminating the need for vasectomy would be beneficial from the economic and animal welfare point of view. Our aim was to develop a transgene-based alternative to the surgical vasectomy procedure. We generated several transgenic mouse lines expressing a Protamine-1 (Prm1) EGFP fusion protein under the transcriptional and translational regulatory control of Prm1. Male mice from lines showing moderate transgene expression were fully fertile whereas strong overexpression of the Prm1-EGFP fusion protein resulted in complete and dominant male sterility without affecting the ability to mate and to produce copulatory plugs. Sterility was due to impaired spermatid maturation affecting sperm viability and motility. Furthermore, sperm having high Prm1-EGFP levels failed to support preimplantation embryonic development following Intracytoplasmic Sperm Injection (ICSI). The "genetic vasectomy system" was further improved by genetically linking the dominant male sterility to ubiquitous EGFP expression in the soma as an easy phenotypic marker enabling rapid genotyping of transgenic males and females. This double transgenic approach represents a reliable and cost-effective "genetic vasectomy" procedure making the conventional surgical vasectomy methodology obsolete.
A flexible image smoothing and segmenting prior to parametric estimation (2002)

PET images suffer from statistical fluctuations where pixels representing the same tissue present different amplitudes, especially in short frames acquired in dynamic studies. Another difficulty is the time consuming in fitting images pixel by pixel in order to obtain parametric images. In the present work, a flexible method based on spatial and temporal pixel variance to compute parametric images is reported. For fluorodeoxyglucose and [/sup 15/O]-labeled water brain studies, a template image is obtained using: (1) summed frames, (2) thresholds to exclude background, (3) segmentation based on coefficients of variation and correlation coefficients of neighboring pixels, and (4) parameter estimation by dynamic fitting (DYN) or autoradiographic (ARG) method. Visually better images and images of parameters other than regional cerebral metabolic rates for glucose (rCMRGlc) or regional cerebral blood flow (rCBF) are obtained. For comparison, rCMRGlc and rCBF in both DYN and ARG methods estimated from segmented and usual images are compared. The maximal relative error is found to be 4% for ARG rCMRGlc, 10% for DYN rCMRGlc, and 17% for DYN rCBF, while the F-test shows no difference between values estimated from segmented and usual images. This technique allows more accurate parameter estimation in a reduced computation time.
Early Symptoms and Neurological Findings in Demented Subjects from a Community Survey (1995)

The prevalence of the symptoms at disease onset reported by close informants, in an unselected group of demented elderly, is presented in this study. Of the 174 dementia cases, 98 were Alzheimer disease (AD), 41 were vascular dementia (VaD), and 35 were other dementias. In 42% of AD subjects, single memory deficit was the earliest problem, while in 56% of VaD cases, the tendency was to present two or more disturbances in the early stages. Slightly younger mean age at onset was reported in VaD than in AD cases. Our results support the hypothesis that the debut of the dementia is variable with any combination of symptoms. However, when memory problems start, assessment is needed. Among the neurological findings in the clinical examination, extrapyramidal signs were present in 25% of all dementia cases and in 20% of AD cases. A higher frequency of extrapyramidal signs was present in more severe cases, confirming previous reports of the unfavorable prognostic value of these signs.
Planned High-brightness Channeling Radiation Experiment at Fermilab's Advanced Superconducting Test Accelerator (2014)

In this contribution we describe the technical details and experimental setup of our study aimed at producing high-brightness channeling radiation (CR) at Fermilab’s new user facility the Advanced Superconducting Test Accelerator (ASTA). In the ASTA photoinjector area electrons are accelerated up to 40-MeV and focused to a sub-micron spot on a ~40 micron thick carbon diamond, the electrons channel through the crystal and emit CR up to 80-KeV. Our study utilizes ASTA’s long pulse train capabilities and ability to preserve ultra-low emittance, to produce the desired high average brightness.
Generalized concatenation of convolutional codes (1996)

Abstract Generalized concatenation of inner and outer convolutional codes is studied. The essential problem is the partitioning of the inner code. A construction procedure to obtain a suitable equivalent description for a given code is derived, which gives the best possible distances in the partitioned subcodes. The construction rule is illustrated with two examples. A small code is studied to emphasize the ideas of the construction and a large code, namely the satellite standard code, demonstrates the considerable gains in decoding performance when using generalized concatenation. Furthermore, the possibilities for iterative decoding are pointed out.
Innate immune cell activation and epigenetic remodeling in symptomatic and asymptomatic atherosclerosis in humans in vivo (2016)

Circulating monocytes of patients with symptomatic, but not asymptomatic, atherosclerosis have a pro-inflammatory phenotype and increased expression of glycolytic enzymes, associated with epigenetic remodeling at the level of histone methylation.
Novel vanadium(II) amine complexes: a facile entry in the chemistry of divalent vanadium. Synthesis and characterization of mononuclear L4VCl2 [L = amine, pyridine]: x-ray structures of trans-(TMEDA)2VCl2 [TMEDA = N,N,N',N'-tetramethylethylenediamine] and trans-Mz2V(py)2 [Mz = o-C6H4CH2N(CH3)2, py = pyridine] (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNovel vanadium(II) amine complexes: a facile entry in the chemistry of divalent vanadium. Synthesis and characterization of mononuclear L4VCl2 [L = amine, pyridine]: x-ray structures of trans-(TMEDA)2VCl2 [TMEDA = N,N,N',N'-tetramethylethylenediamine] and trans-Mz2V(py)2 [Mz = o-C6H4CH2N(CH3)2, py = pyridine]Jilles J. H. Edema, Walter Stauthamer, Fre Van Bolhuis, Sandro Gambarotta, Wilberth J. J. Smeets, and Anthony L. SpekCite this: Inorg. Chem. 1990, 29, 7, 1302–1306Publication Date (Print):April 1, 1990Publication History Published online1 May 2002Published inissue 1 April 1990https://doi.org/10.1021/ic00332a003RIGHTS & PERMISSIONSArticle Views821Altmetric-Citations70LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (664 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Supplemental Figure 3 from Preclinical Assessment of CD171-Directed CAR T-cell Adoptive Therapy for Childhood Neuroblastoma: CE7 Epitope Target Safety and Product Manufacturing Feasibility (2023)

&lt;p&gt;Supplemental Figure 3 Monitoring of NHPs after CAR T cell infusion.&lt;/p&gt;
Semantic interoperability for asset communication within smart factories (2017)

Industrie 4.0 (I4.0) aims at a manufacturer-independent, vertical- and horizontal-oriented communication and cooperation within smart factories. This is only manageable using international standards. The so-called reference architecture model for Industrie 4.0 (RAMI4.0) and the requirement specification of an I4.0 component are already available. RAMI4.0 could be the basis for the interoperability of the interactions. The working group “Semantic and interaction model for I4.0 components” (GMA 7.20) made progress in this direction. The language used for the interaction of I4.0 components needs model definitions for the interaction consisting of the structure of the components, syntax for the description of the messages and the means to assign the meaning to the language elements. This paper discusses the results for a broader audience.
Evolution of VoIP Signaling Protocols (2003)

Chapter 3 presents evolution of the VoIP signaling protocols beginning from the ones which assume interworking with the traditional switch-based infrastructure (PSTN) in mandatory to those which use totally Internet based protocols and paradigms (server-router based network architecture). We put special emphasis on the activities which are focusing on making the PSTN domain enhanced telephone call features available to the IP domain clients like PC based soft phones or hardware based IP phones.
Distributed Tracking Control for Linear Multiagent Systems With a Leader of Bounded Unknown Input (2012)

This technical note considers the distributed tracking control problem of multiagent systems with general linear dynamics and a leader whose control input is nonzero and not available to any follower. Based on the relative states of neighboring agents, two distributed discontinuous controllers with, respectively, static and adaptive coupling gains, are designed for each follower to ensure that the states of the followers converge to the state of the leader, if the interaction graph among the followers is undirected, the leader has directed paths to all followers, and the leader's control input is bounded. A sufficient condition for the existence of the distributed controllers is that each agent is stabilizable. Simulation examples are given to illustrate the theoretical results.
Fast implementations of the filtered-X LMS and LMS algorithms for multichannel active noise control (1999)

In some situations where active noise control could be used, the well-known multichannel version of the filtered-X least mean square (LMS) adaptive filter is too computationally complex to implement. We develop a fast, exact implementation of this adaptive filter for which the system's complexity scales according to the number of filter coefficients within the system. In addition, we extend computationally efficient methods for effectively removing the delays of the secondary paths within the coefficient updates to the multichannel case, thus yielding fast implementations of the LMS adaptive algorithm for multichannel active noise control. Examples illustrate both the equivalence of the algorithms to their original counterparts and the computational gains provided by the new algorithms.
Nozzle Flow in a Laser-Heated Hydrogen Rocket (1979)

Covers advancements in spacecraft and tactical and strategic missile systems, including subsystem design and application, mission design and analysis, materials and structures, developments in space sciences, space processing and manufacturing, space operations, and applications of space technologies to other fields.
Artificial Neural Networks to extract Knowledge from EEG (2005)

EEG signals are very difficult to interpret because they are dynamic, non-linear and non-stationary signals. Human expertise also indicates that multi-level analysis must be performed to integrate various sources of knowledge. In this paper, we review these difficulties and propose that artificial neural networks could be good candidates to handle such a difficult problem.
Ergodic control of a heterogeneous population and application to electricity pricing (2022)

We consider a control problem for a heterogeneous population composed of agents able to switch at any time between different options. The controller aims to maximize an average gain per time unit, supposing that the population is of infinite size. This leads to an ergodic control problem for a "mean-field" Markov Decision Process in which the state space is a product of simplices, and the population evolves according to controlled linear dynamics. By exploiting contraction properties of the dynamics in Hilbert's projective metric, we prove that the infinite-dimensional ergodic eigenproblem admits a solution and show that the latter is in general non unique. This allows us to obtain optimal strategies, and to quantify the gap between steady-state strategies and optimal ones. In particular, we prove in the one-dimensional case that there exist cyclic policies -- alternating between discount and profit taking stages -- which secure a greater gain than constant-price policies. On numerical aspects, we develop a policy iteration algorithm with "on-the-fly" generated transitions, specifically adapted to decomposable models, leading to substantial memory savings. We finally apply our results on realistic instances coming from an electricity pricing problem encountered in the retail markets, and numerically observe the emergence of cyclic promotions for sufficient inertia in the customer behavior.
Thin-film deposition process by pulsed ion-beam generated ablation plasma (2004)

Pulsed ion-beam evaporation (IBE) is a practical technique of thin film deposition. In this paper, the process of IBE is studied with concentration on the importance of physical properties of the target material. The experiments were carried out by using different kinds of metal targets. The results have helped us in understanding the physical relation between the ablation plasma behavior and the thin-film surface morphology.
The 1997 American Diabetes Association Criteria Versus the 1985 World Health Organization Criteria for the Diagnosis of Abnormal Glucose Tolerance: Poor agreement in the Hoorn Study (1998)

In this study both sets of criteria diagnosed a similar number of diabetic subjects, but many of the subjects shifted between glucose intolerance categories. With either set of criteria, a considerable number of subjects at risk of developing diabetes and subjects carrying an increased risk of cardiovascular disease, as reflected by an adverse cardiovascular risk profile, will be missed.
A Novel Bismuth-Chitosan Nanocomposite Sensor for Simultaneous Detection of Pb(II), Cd(II) and Zn(II) in Wastewater (2019)

A novel bismuth (Bi)-biopolymer (chitosan) nanocomposite screen-printed carbon electrode was developed using a Bi and chitosan co-electrodepositing technique for detecting multiple heavy metal ions. The developed sensor was fabricated with environmentally benign materials and processes. In real wastewater, heavy metal detection was evaluated by the developed sensor using square wave anodic stripping voltammetry (SWASV). The nanocomposite sensor showed the detection limit of 0.1 ppb Zn<sup>2+</sup>, 0.1 ppb Cd<sup>2+</sup> and 0.2 ppb Pb<sup>2+</sup> in stock solutions. The improved sensitivity of the Bi-chitosan nanocomposite sensor over previously reported Bi nanocomposite sensors was attributed to the role of chitosan. When used for real wastewater samples collected from a mining site and soil leachate, similar detection limit values with 0.4 ppb Cd<sup>2+</sup> and 0.3 ppb Pb<sup>2+</sup> were obtained with relative standard deviations (RSD) ranging from 1.3% to 5.6% (<i>n</i> = 8). Temperature changes (4 and 23 °C) showed no significant impact on sensor performance. Although Zn<sup>2+</sup> in stock solutions was well measured by the sensor, the interference observed while detecting Zn<sup>2+</sup> in the presence of Cu<sup>2+</sup> was possibly due to the presence of Cu-Zn intermetallic species in mining wastewater. Overall, the developed sensor has the capability of monitoring multiple heavy metals in contaminated water samples without the need for complicated sample preparation or transportation of samples to a laboratory.
Libertad y Expresión Estética. Reflexiones en Torno de las Vanguardias (2005)

Americanae nace como un proyecto conjunto que surge dentro de la Red Europea de Información y Documentación sobre América Latina (REDIAL), y que ha afrontado la Biblioteca de la Agencia Española de Cooperación Internacional para el Desarrollo (AECID). Esta nueva biblioteca virtual hace más accesibles los libros digitales de tema americanista a los investigadores y usuarios interesados de cualquier parte del mundo.