gebhart/patrepeval huggingface dataset:
Activity of a novel, dual PI3-kinase/mTor inhibitor NVP-BEZ235 against primary human pancreatic cancers grown as orthotopic xenografts (2009)

The phosphatidylinositol-3-kinase (PI3K)/Akt signalling pathway is frequently deregulated in pancreatic cancers, and is believed to be an important determinant of their biological aggression and drug resistance. NVP-BEZ235 is a novel, dual class I PI3K/mammalian target of rapamycin (mTor) inhibitor undergoing phase I human clinical trials. To simulate clinical testing, the effects of NVP-BEZ235 were studied in five early passage primary pancreatic cancer xenografts, grown orthotopically. These tumours showed activated PKB/Akt, and increased levels of at least one of the receptor tyrosine kinases that are commonly activated in pancreatic cancers. Pharmacodynamic effects were measured following acute single doses, and anticancer effects were determined in separate groups following chronic drug exposure. Acute oral dosing with NVP-BEZ235 strongly suppressed the phosphorylation of PKB/Akt, followed by recovery over 24 h. There was also inhibition of Ser235/236 S6 ribosomal protein and Thr37/46 4E-BP1, consistent with the effects of NVP-BEZ235 as a dual PI3K/mTor inhibitor. Chronic dosing with 45 mg kg(-1) of NVP-BEZ235 was well tolerated, and produced significant tumour growth inhibition in three models. These results predict that agents targeting the PI3K/Akt/mTor pathway might have anticancer activity in pancreatic cancer patients, and support the testing of combination studies involving chemotherapy or other molecular targeted agents.
Improved procedure for determining glutathione in plasma as an index of myocardial oxidative stress. (1987)

Glutathione plays an important role in the detoxification processes of electrophilic metabolites of xenobiotics and oxygen free radicals, such that release of reduced and oxidized glutathione into the plasma is considered a reliable index of oxidative stress. However, reduced glutathione in plasma undergoes spontaneous autoxidation, with mixed disulfide formation. We developed a new, simple, quick method to overcome this problem by treating the blood, immediately after collection, with thiol reagents. We add 5,5'-dithiobis(2-nitrobenzoic acid) and N-ethylmaleimide to the blood before determination of total and oxidized glutathione, respectively. We find the proposed assay useful for investigating oxidative stress in clinical situations.
Sunday Canyon (SCA) (1978)

Information from: C. E. Yunker, Rocky Mountain Laboratory, NIAID, NIH, Hamilton, Montana 59840, USA, 20 January 1976.Antigenic group: Ungrouped.Original source: Isolated by M. D. Corwin at Rocky Mountain Laboratory from 25 adult female Argas (Argas) cooleyi ticks collected by hand by J. E. George on 29 June 1969 at Randall County, Texas, USA, 19 km E of Canyon, Lat. 34°58.6'N, Long. 102°45'W. Habitat: Under flakes of rock on cliff-face, below active cliff swallow colony in Sunday Canyon, a part of the northwest end of Palo Duro Canyon. Storage: Held alive at ambient temperatures for 8½ mo, then triturated and held at -70°C for additional 14½ mo.Method of isolation in laboratory: Triturated tick suspension inoculated ic into 2- to 4-day-old infant mice on 26 May 1971.Validity of isolation: Reisolation not tried but virus different from any other virus in laboratory and in mouse colony.
Selective Reduction of Halopolyfluorocarbons by Organosilicon Hydrides (1998)

It is demonstrated that silicon hydrides can be used for reduction of polyfluorinated halocarbons. For example, the reaction between CF(3)CCl(2)F and excess triethylsilane, catalyzed by benzoyl peroxide, leads to the formation of a mixture containing CF(3)CHClF (major), CF(3)CH(2)F, and ClSi(C(2)H(5))(3). On the other hand, the reaction of chlorofluoroalkanes, containing an internal -CCl(2)- group readily proceeds with reduction of both chlorines, leading to compounds such as (CF(3))(2)CH(2) and CF(3)CH(2)C(2)F(5). In contrast to chlorofluoroalkanes, bromofluoroalkanes are much more reactive and reaction with hydrosilane rapidly proceeds without the catalyst at elevated temperature.
Response to Growth Hormone in Children with Idiopathic Short Stature (1990)

A multicentre randomized trial of human growth hormone (GH) treatment was carried out in 121 children with short stature who did not meet the classic criteria for GH deficiency. In the first year of the trial, half of the children received treatment with recombinant somatropin 0.1 mg/kg (0.27 IU/kg) three times weekly and showed a significant increase in mean growth velocity from a pretreatment value of 4.6 +/- 1.1 to 7.5 +/- 1.2 cm/year (mean +/- SD). The growth velocity of the untreated children did not change significantly. The growth velocity of the control group (including 10 pubertal children) increased from 4.2 +/- 1.3 to 5.0 +/- 1.4 cm/year. In the second year, half of the control group received treatment with somatropin, 0.1 mg/kg (0.27 IU/kg) three times weekly, while the remainder received the same weekly dose on a once-daily basis. The mean growth velocity increased in both cases to 8.2 +/- 1.4 and 9.0 +/- 1.6 cm/year, respectively. The group treated during the first year was also divided into two groups in the second year. One group continued with the original treatment regimen, resulting in a mean growth velocity of 6.8 +/- 1.8 cm/year. The other group changed to once-daily treatment at the same weekly dose and the mean growth velocity for this group in the second year was 7.8 +/- 1.4 cm/year. The gain in height age in both of these groups exceeded the bone age in both the first and second years of treatment, suggesting a gain in predicted adult height.(ABSTRACT TRUNCATED AT 250 WORDS)
Replacement of fishmeal by low‐cost animal protein as a quality fish feed ingredient for indian major carp, labeo rohita, fingerlings (1994)

Abstract Five formulated diets containing 350 g kg ‐1 crude protein were prepared replacing 0, 25, 50, 75 and 100% of the fish meal content which silkworm pupae ( Bombyx mori ) and clam meat as a dietary protein source, and were fed to Indian major carp ( Labeo rohita ) fingerlings of 2.0–2.2 g size under laboratory conditions. A growth study over a period of 90 days showed that a diet containing 50% of its protein as fishmeal had significantly higher ( P ≤0.05) growth with values of 1.64, 1.92, 1.48 for specific growth rate, food conversion ratio and protein efficiency ratio, respectively. Significantly lower growth ( P ≤0.05) was observed with diets having all or none of its protein as fish meal. This experiment with Labeo rohita fingerlings revealed a significantly better utilisation of the diet when half the protein in a fishmeal diet was replaced by protein in the form of silkworm pupae and clam meat.
White Light-Emitting Device on Flexible Plastic Substrates (2005)

Current density [mA/cm] L um in an ce [c d/ m 2 ] Voltage [V] Over last several years, light-emitting devices based on organic materials have been attractive research subjects because of their potential applicability to large size flat panel displays and solid-state lighting with low fabrication costs and easy manufacturing processes. Recently, the topic of white light generation from singlelayer OLEDs has also been a very active research area since this type of device can be used as a plane light source for current large size liquid-crystal display (LCD) TVs and/or flexible full color displays implemented in combination with the color filters. Until now, all studies for generating the white light emission from either small molecules [1] or polymers [2, 3] based devices have been based on glass substrates. However, for the future flexible display or flexible solidstate lighting applications, the development of the white light on flexible plastic substrates is essential. Fig 1. Luminance-current-voltage characteristics of blend PLED.
A computationally designed fluorescent biosensor for D-serine (2020)

Summary Solute-binding proteins (SBPs) have evolved to balance the demands of ligand affinity, thermostability and conformational change to accomplish diverse functions in small molecule transport, sensing and chemotaxis. Although the ligand-induced conformational changes that occur in SBPs make them useful components in biosensors, they are challenging targets for protein engineering and design. Here we have engineered a D-alanine-specific SBP into a fluorescent biosensor with specificity for the signaling molecule D-serine (D-serFS). This was achieved through binding site and remote mutations that improved affinity ( K D = 6.7 ± 0.5 μM), specificity (40-fold increase vs. glycine), thermostability (Tm = 79 °C) and dynamic range (~14%). This sensor allowed measurement of physiologically relevant changes in D-serine concentration using two-photon excitation fluorescence microscopy in rat brain hippocampal slices. This work illustrates the functional trade-offs between protein dynamics, ligand affinity and thermostability, and how these must be balanced to achieve desirable activities in the engineering of complex, dynamic proteins.
Griffith fracture equation—An experimental test (1975)

The Griffith fracture equation was not followed when the strengths of rods of soda-lime glass tested immediately after abrading and then after abrading and ageing for 24 h in water were compared. The aged samples were stronger than samples not aged, but the cracks in both were of nealry the same length. Two possible explanations of this discrepancy are explored.
PLACEMENT OF PHOSPHORUS AND NITROGEN FERTILIZERS FOR MINIMUM TILL CORN UNDER SPRINKLER IRRIGATION ((ZEA MAYS L.), NO-TILL, EFFICIENCY) (1985)

Three maize (Zea mays L.) experiments were established in 1983 and 1984 to evaluate the effectiveness of various methods and sources of nitrogen (N) and phosphorus (P) in a reduced-till sprinkler irrigation practice. Phosphorus method-source studies were conducted on a calcareous soil at Loup City, NE and an acid soil at Mead, NE. Dual placed (DP) N and P in a localized band (anhydrous ammonia applied with liquid P sources) increased P uptake and corn grain yields on a calcareous soil as compared to P banded to the side of the seed (BS) and banded below the seed (BB). Broadcast preplant (BRP) applications were equally as effective as DP methods under reduced tillage practices. Explanation of enhanced DP yields and P uptake could lie in the synergistic effect of N and P placed together, especially when the ammoniacal form of N is used. Urea phosphate (UP) provided greater yields and total P uptake in both the grain and stover as compared to P sources ammonium polyphosphate (APP) and diammonium phosphate (DAP) at the calcareous soil site. The greater early uptake of P when BB and BS did not increase grain yield and or P uptake versus DP and BRP methods of P placement. Anhydrous ammonia injected preplant and or sidedress provided superior yields and uptake efficiencies when compared to all other sources of N used (sulfur coated urea, urea ureaphosphate, urea and urea ammoniumnitrate). Data suggest that N sources should be placed below the soil surface in reduced-tillage practices to prevent microbial immobilization and volatilization losses. Nitrogen from ear-leaf tissue samples (analyzed for total-N) that were taken at early silking was highly correlated with yield. Results of ear-leaf analysis might be used to recommend the amount of N to be applied through irrigation during grain fill. Tissue samples were taken throughout the growth cycle of maize and analyzed for phosphate phosphorus (dilute acetic acid extractable) and total phosphorus (nitric-perchloric acid digestion). High correlation was found between the results of these two procedures, indicating that one method is as good as the other for assessing the relative P status of the plant. The dilute acid extractable measurement can also be used to predict total P uptake by the plant.
Managing Network Security: Balancing risk (1998)

Computing operated in an almost universally a networked environment, but the technical aspects of information protection have not kept up. As a result, the success of information security programmes has increasingly become a function of our ability to make prudent management decisions about organizational activities. Managing Network Security takes a management view of protection and seeks to reconcile the need for security with the limitations of technology.
Life cycle assessment of CO₂-based C1-chemicals (2015)

Carbon dioxide (CO₂) and hydrogen are promising feedstocks for a sustainable chemical industry. Currently, the conversions of CO₂ and hydrogen are most advanced for chemicals with 1 carbon atom, the so-called C1-chemicals, with the first pilot plants in operation. For formic acid, carbon monoxide, methanol, and methane, CO₂-based C1-chemicals can reduce the impacts of fossil depletion and global warming through the substitution of fossil-based processes. Existing life cycle assessment (LCA) studies for carbon monoxide, methanol, and methane show that a reduction in environmental impacts is achieved if hydrogen is supplied by water electrolysis with renewable electricity. However, in the foreseeable future, renewable electricity will be limited. Thus, from an environmental point of view, renewable electricity should be employed for chemical processes in the order of highest environmental impact reductions. Environmental impact reductions are the difference in environmental impacts of fossil-based processes and CO₂-based processes. In this study, we compared the CO₂-based production of formic acid, carbon monoxide, methanol, and methane. We determined the reduction of global warming and fossil depletion impacts using 1 kg of hydrogen. Our results show that the CO₂-based production of formic acid achieves the highest environmental impact reductions, followed by carbon monoxide and methanol. The lowest environmental impact reductions are achieved for CO₂-based methane production. Our analysis reveals that the CO₂-based production of formic acid can reduce environmental impacts, compared to the fossil-based process, even if hydrogen is supplied by fossil-based steam-methane-reforming.
Key Odorants from the Fragrant Bolete, Suillus punctipes (2020)

The fragrant bolete, <i>Suillus punctipes</i> (Peck) Singer, is an edible mushroom with a unique aroma reminiscent of mushroom and citrus peel with an undertone of apricot. Thirty-five odorants were identified using solvent-assisted flavor evaporation (SAFE) and aroma extract dilution analysis (AEDA). Fourteen odorants including those with flavor dilution (FD) factors ≥64 were quantitated using stable isotope dilution assays (SIDA). Some odorants with high OAVs included 1-octen-3-one (OAV 164368), 1-octen-3-ol (OAV 3421), linalool (OAV 812), and nonanal (OAV 487). An odor simulation model was prepared closely matching the aroma of the mushroom. Omissions experiments revealed that 1-octen-3-one, 1-octen-3-ol, (2<i>E</i>)-oct-2-enal, linalool, δ-dodecalactone, and a mixture of three aldehydes, octanal, nonanal, and decanal, were essential odorants for the aroma profile. Enantiomeric ratios were determined for several odorants employing chiral chromatography. The results from this study lay the groundwork for future studies in the aroma chemistry of <i>S. punctipes</i> and other mushrooms from the <i>Suillus</i> genus.
Raman and infrared spectra of crystalline 9‐methyladenine and its methylmercury complexes (1981)

Abstract The Raman and infrared spectra of polycrystalline samples of 9‐methyladenine and three of its methylmercury complexes have been recorded. These complexes include the N1‐coordinated and the N1‐coordinated‐NH 2 ‐substituted derivatives, the third compound being probably N1‐and N7‐coordinated. Spectral changes occurring upon complexation are analysed, and comparisons are made with the corresponding changes in the spectra of various adenine derivatives which are known to form complexes with CH 3 Hg + in aqueous solution.
Mutation analysis of H19 andNAP1L4 (hNAP2) candidate genes and IGF2 DMR2 in Beckwith-Wiedemann syndrome (2000)

Editor—Beckwith-Wiedemann syndrome (BWS) is a human overgrowth disorder with a variable phenotype and genetic heterogeneity. Recent data indicate that the BWS locus is subject to genomic imprinting and current evidence shows that in many patients the disease is associated with epigenetic lesions of genes on 11p15.5. BWS is characterised by pre- and postnatal overgrowth, macroglossia, and anterior abdominal wall defects. Additional, but variable complications include organomegaly, hypoglycaemia, hemihypertrophy, genitourinary abnormalities, and a predisposition to embryonal tumours in about 5% of patients.1 The genetics of BWS are complex, but parent of origin effects, suggesting genomic imprinting, have been implicated in the pathogenesis of three major groups of patients2: (1) for patients (∼2%) with chromosome 11p15.5 abnormalities, duplications are of paternal origin and balanced translocations or inversion breakpoints of maternal origin; (2) in familial cases (∼15% of all cases) which exhibit more complete penetrance with maternal transmission; and (3) approximately 20% of sporadic cases have uniparental disomy (paternal isodisomy) for chromosome 11p15.5. Cloning of genes in the vicinity of BWSCR1, the most distal breakpoint cluster associated with BWS balanced cytogenetic anomalies, and within the area of minimal disomy present in cases of paternal isodisomy, has led to the identification of a group of genes as potential candidates in the aetiopathology of BWS. Thus, multiple imprinted genes bounded centromerically by NAP1L4 and telomerically by L23mrp ( RPL23L ) have been identified.3-6 

For a gene to be a good candidate to account for a significant number of BWS cases, it should map to this region and constitute either a paternally expressed growth promoter or a maternally expressed growth inhibitor. However, because factors involved in maintaining or modifying genomic imprints may affect the epigenotype and therefore expression status of imprinted genes, it is possible that an underlying lesion in a non-imprinted …
Deletion of a Novel F-Box Protein, MUS-10, in Neurospora crassa Leads to Altered Mitochondrial Morphology, Instability of mtDNA and Senescence (2010)

Abstract While mitochondria are renowned for their role in energy production, they also perform several other integral functions within the cell. Thus, it is not surprising that mitochondrial dysfunction can negatively impact cell viability. Although mitochondria have received an increasing amount of attention in recent years, there is still relatively little information about how proper maintenance of mitochondria and its genomes is achieved. The Neurospora crassa mus-10 mutant was first identified through its increased sensitivity to methyl methanesulfonate (MMS) and was thus believed to be defective in some aspect of DNA repair. Here, we report that mus-10 harbors fragmented mitochondria and that it accumulates deletions in its mitochondrial DNA (mtDNA), suggesting that the mus-10 gene product is involved in mitochondrial maintenance. Interestingly, mus-10 begins to senesce shortly after deletions are visualized in its mtDNA. To uncover the function of MUS-10, we used a gene rescue approach to clone the mus-10 gene and discovered that it encodes a novel F-box protein. We show that MUS-10 interacts with a core component of the Skp, Cullin, F-box containing (SCF) complex, SCON-3, and that its F-box domain is essential for its function in vivo. Thus, we provide evidence that MUS-10 is part of an E3 ubiquitin ligase complex involved in maintaining the integrity of mitochondria and may function to prevent cellular senescence.
Generation of a rabbit model of cystic fibrosis by injection of a zinc finger nuclease mRNA in one cell embryos (2011)

Atelier de Transgénèse et de Recombinaison Homologue<br/>Atelier de Transgénèse et de Recombinaison Homologue
Association Colloids in Nonaqueous Fluids. Viscosity and Drag Reduction Characteristics (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAssociation Colloids in Nonaqueous Fluids. Viscosity and Drag Reduction CharacteristicsHayward R. Baker, Robert N. Bolster, Paul B. Leach, and Ralph C. LittleCite this: Ind. Eng. Chem. Prod. Res. Dev. 1970, 9, 4, 541–548Publication Date (Print):December 1, 1970Publication History Published online1 May 2002Published inissue 1 December 1970https://pubs.acs.org/doi/10.1021/i360036a015https://doi.org/10.1021/i360036a015research-articleACS PublicationsRequest reuse permissionsArticle Views93Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Design and Realization of a Multiple Access Wireless Power Transfer System for Optimal Power Line Communication Data Transfer (2019)

In this contribution, the authors evaluate the possibility of using separated access points for power and data transfer in a coupled Wireless Power Transfer-Powerline Communication system. Such a system has been previously proposed by the authors for specific applications, in which Wireless Power Transfer (WPT) should take place in a system where data are transmitted over the power grid. In previous works the authors have performed lab tests on a two coils WPT system equipped with a set of filters to also allow an efficient data transfer. When a multiple coil WPT system is chosen, additional possibilities arise: the access point for power and data can be differentiated, with the aim of maintaining the designed power efficiency and increase data transfer capacity. In this study a four coils WPT system is thoroughly analyzed, modelled, implemented and measured, and a set of guidelines for the correct design (in terms of performance optimization) of the data transfer is given.
Unsteady Pressure Measurement on NACA0012 Model Using Global Low-Speed Unsteady PSP Technique (2011)

Pressure fluctuation field accompanied by a trailing edge noise on a 2-dimensional NACA0012 model was measured by the low-speed unsteady Pressure-Sensitive Paint (PSP) technique using a high-speed camera. Maximum pressure fluctuation on the model at U=28.0 m/s was about 150Pa p-p and its fundamental frequency was at 920Hz (St=0.985). Its global pressure fluctuation distribution around its trailing edge was measured. Anodizedaluminum PSP (AA-PSP), which is one of the fast-response PSPs, was coated on the model and illuminated by a 7W blue laser diode. AA-PSP luminescence was measured by a CMOS high-speed camera with 10k frame-per-second sampling rate and more than 50,000 images were acquired both under wind-on and wind-off condition at each case. Images were processed using FFT process including ensemble average and spectral subtraction, and reduced to the power spectrum of pressure fluctuation. The results could visualize the detailed distribution of the pressure fluctuation on the model. The difference between different test condition and flow speed were clearly detected. The results also compared with corresponding data of pressure transducers and another unsteady PSP technique, the scanning unsteady PSP technique. Both of the pressure fluctuation profile and quantitative power value measured by the high-speed unsteady PSP technique were good agreement with the other measurement data.