gebhart/patrepeval huggingface dataset:
Lessons Learned in Patients with Large Steinstrasse (1989)

Experience with 19 patients (25 ureters) who suffered the complication of a large steinstrasse (a third or more of the ureteral length) has led to lessons regarding the management of this complication as well as to insights into patient presentation, metabolic consequences, and the efficiency of diagnostic and therapeutic modalities. Few symptoms were present in a large percentage of patients despite urinary obstruction, decreased renal function, infection and in several cases impending sepsis. Large stone burdens, bilateral treatment, inability to debulk stone burden before extracorporeal shock wave lithotripsy and unexpected fragment movement were definite predisposing factors in the development of this complication. Double pigtail stents and percutaneous nephrostomy alone did not always prevent or resolve the problem. Combined use of percutaneous nephrostomy and ureteroscopic ultrasonic or laser lithotripsy appears to be the most effective treatment modality in patients who fail brief observation. This approach can be combined under appropriate circumstances with a secondary extracorporeal shock wave lithotripsy or percutaneous nephrolithotripsy treatment in the staged management of complex upper urinary tract calculous disease.
Impact of Methoxy Substituents on Thermally Activated Delayed Fluorescence and Room-Temperature Phosphorescence in All-Organic Donor–Acceptor Systems (2019)

Thermally activated delayed fluorescence (TADF) and room-temperature phosphorescence (RTP) are known to occur in organic D-A-D and D-A systems where the donor group contains the phenothiazine unit and the acceptor is dibenzothiophene- S, S-dioxide. This study reports the synthesis and characterization of one new D-A and four new D-A-D systems with methoxy groups on the phenothiazine to examine their effect on emission properties in the zeonex matrix. X-ray analysis and highly specialized NMR techniques were used to characterize asymmetric methoxy-substituted derivative 3b, which is chiral at N because of an extremely high flipping barrier at the phenothiazine N atom. Based on hybrid-density functional theory computations, the methoxy substituents tune the relative stabilities of the axial conformers with respect to equatorial conformers of the phenothiazine units, depending on their substitution position. This conformational effect significantly influences both TADF and RTP contributions compared to the parent D-A-D system. It is also demonstrated that the equatorial forms of D-A-D and D-A systems in zeonex exhibit TADF. Additionally, the methoxy groups promote luminescence in D-A-D systems where only axial conformers exist. This work reveals further design opportunities for more efficient TADF and RTP molecules.
Data from Body Size, Physical Activity, Early-Life Energy Restriction, and Associations with Methylated Insulin-like Growth Factor–Binding Protein Genes in Colorectal Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Background:&lt;/b&gt; We investigated body size, physical activity, and early-life energy restriction in relation to colorectal tumors with and without methylated insulin-like growth factor–binding protein (&lt;i&gt;IGFBP&lt;/i&gt;) genes, which are putative tumor-suppressor genes.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Methods:&lt;/b&gt; We determined &lt;i&gt;IGFBP2&lt;/i&gt;, &lt;i&gt;IGFBP3&lt;/i&gt;, and &lt;i&gt;IGFBP7&lt;/i&gt; promoter CpG island hypermethylation in tumors of 733 colorectal cancer cases from the Netherlands Cohort Study (&lt;i&gt;N&lt;/i&gt; = 120,852). Participants self-reported lifestyle and dietary factors at baseline in 1986. Using a case–cohort approach (&lt;i&gt;N&lt;/i&gt; subcohort = 5,000), we estimated hazard ratios (HR) for colorectal cancer by extent of &lt;i&gt;IGFBP&lt;/i&gt; methylation.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Comparison of the highest versus lowest sex-specific tertiles of adult body mass index (BMI) gave multivariable-adjusted HRs [95% confidence intervals (CI)] for colorectal cancers with 0 (18.7%), 1 (29.5%), 2 (32.4%), and 3 (19.5%) methylated genes of 1.39 (0.88–2.19), 1.11 (0.77–1.62), 1.67 (1.17–2.38), and 2.07 (1.29–3.33), respectively. Other anthropometric measures and physical activity were not associated with colorectal cancer risk by extent of &lt;i&gt;IGFBP&lt;/i&gt; methylation, except height in sex-specific analyses for women. Exposure to energy restriction during the Dutch Hunger Winter versus nonexposure gave HRs (95% CIs) for colorectal cancers with 0, 1, 2, and 3 methylated genes of 1.01 (0.67–1.53), 1.03 (0.74–1.44), 0.72 (0.52–0.99), and 0.50 (0.32–0.78), respectively.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Adult BMI, height (in women only), and early-life energy restriction were associated with the risk of having a colorectal tumor characterized by &lt;i&gt;IGFBP&lt;/i&gt; methylation.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Impact:&lt;/b&gt; Body size may particularly increase the risk of &lt;i&gt;IGFBP&lt;/i&gt; gene–methylated colorectal tumors; this finding might facilitate more targeted approaches to prevent obesity-related colorectal cancers. &lt;i&gt;Cancer Epidemiol Biomarkers Prev; 23(9); 1852–62. ©2014 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Molecular profiling of renal cell carcinoma presenting as iris metastasis (2022)

This report illustrates how pathological examination of a small iris lesion led to the discovery of a previously unknown systemic malignancy at a resectable stage. Molecular genetic profiling revealed that even lower grade clones within a high-grade neoplasm have metastatic potential.
Management of patients with non-ST-elevation acute coronary syndromes (2001)

There have been several recent developments in the management of acute coronary syndromes, including a new understanding of physiopathology and the importance of risk-profiling, new prognostic markers, new antiplatelet and antithrombotic treatments, and new information about the value or percutaneous coronary interventions. (editor abstract)
A Multifunctional Metal–Organic Open Framework with a bcu Topology Constructed from Undecanuclear Clusters (2006)

Flexible ligands afford large pores: A novel metal–organic framework constructed from cadmium carboxylate cluster secondary building units and formic acid bridging molecules is reported (see picture). This highly porous material displays rare body-centered cubic topology, as well as good sorption characteristics and optoelectronic properties.
CHROMOSOME NUMBER REPORTS LXXXVII (1985)

These reports are intended as a place of publication of stray cytotaxonomical observations which otherwise might remain unpublished. Preference is given to chromosome numbers for taxa not previously known in this respect or rarely reported, but confirmation of numbers established by three or more previous reports must be declined for financial reasons. Likewise, reports longer than two typewritten pages can be accepted only in exceptional cases. Families, genera and species must be arranged alphabetically, and a brief reference to a single voucher specimen and the place where it is deposited is recommended. Since a critical identification ofthe material is important, collective species names can be accepted only if qualified by subspecific or varietal denotations. Inexact chromosome counts should be avoided as must indirect reports of chromosome numbers through mentioning of meiotic configurations. Contributions should be sent to Askell LOve, 5780 Chandler Court, San Jose, California 95123, U.S.A., who will edit them, if necessary, to fit the norms above.
Tick‐borne encephalitis virus in cows and unpasteurized cow milk from Norway (2018)

Abstract Tick‐borne encephalitis virus (TBEV) is recognized as the most important zoonotic tick‐transmitted virus in Europe. TBEV is mainly transmitted to humans through bites from TBEV‐infected ticks ( Ixodes ricinus and Ixodes persulcatus ). However, alimentary infection after consumption of unpasteurized milk and cheese from domestic ruminants has been reported. There is little information about TBEV in ruminants in Norway. The objectives of this study were to analyse unpasteurized cow milk for TBEV RNA and to study the presence of IgG antibodies to TBEV in the same animals. A total of 112 milk and blood samples were collected from cows from five different farms spread from southern to northern Norway. The milk samples were analysed by an in‐house reverse transcription (RT) real‐time polymerase chain reaction and confirmed by pyrosequencing. Serum samples were screened by a commercial enzyme‐linked immunosorbent assay and verified by a TBEV‐specific serum neutralization test. We found TBEV RNA in unpasteurized milk collected from farms in the municipalities of Mandal, Skedsmo and Brønnøy in 5.4% of the tested animals. Specific antibodies to TBEV were only detected in Arendal, where 88.2% of the tested animals were positive. Further studies on milk containing TBEV RNA should be performed to conclude if TBEV found in unpasteurized milk in Norway is infectious, which could be of great importance in a One Health perspective.
PGCapping (2012)

Optimizing the performance of a chip multiprocessor (CMP) within a power cap has recently received a lot of attention. However, most existing solutions rely solely on DVFS, which is anticipated to have only limited actuation ranges in the future. Power gating shuts down idling cores in a CMP, such that more power can be shifted to the cores that run applications for better CMP performance. However, current preliminary studies on integrating the two knobs focus on deciding the power gating and DVFS levels in a tightly coupled fashion, with much less attention given to the direction of decoupled designs. By decoupling the two knobs that may interfere with each other, individual knob management algorithms can be less complex and more efficient to take advantage of the characteristics of different knobs. This paper proposes PGCapping, a decoupled design to integrate power gating with DVFS for CMP power capping. To fully utilize the power headroom that is reserved through power gating, PGCapping enables per-core overclocking on turned-on cores that run sequential applications. However, per-core overclocking may make some cores age much faster than others and thus become the reliability bottleneck in the whole system. Therefore, PGCapping also uses power gating to balance the core lifetimes. Our empirical results on a hardware testbed show that the proposed scheme achieves up to 42.0% better average application performance than five state-of-the-art power capping baselines for realistic multi-core applications, i.e., a mixed group of PARSEC and SPEC CPU2006 benchmarks. Furthermore, our extensive simulation results with real-world traces demonstrate that a lightweight lifetime balancing algorithm (based on power gating) can increase the CMP lifetime by 9.2% on average.
Impact of Diabetic Stress Conditions on Renal Cell Metabolome (2019)

Diabetic kidney disease is a major complication in diabetes mellitus, and the most common reason for end-stage renal disease. Patients suffering from diabetes mellitus encounter glomerular damage by basement membrane thickening, and develop albuminuria. Subsequently, albuminuria can deteriorate the tubular function and impair the renal outcome. The impact of diabetic stress conditions on the metabolome was investigated by untargeted gas chromatography-mass spectrometry (GC-MS) analyses. The results were validated by qPCR analyses. In total, four cell lines were tested, representing the glomerulus, proximal nephron tubule, and collecting duct. Both murine and human cell lines were used. In podocytes, proximal tubular and collecting duct cells, high glucose concentrations led to global metabolic alterations in amino acid metabolism and the polyol pathway. Albumin overload led to the further activation of the latter pathway in human proximal tubular cells. In the proximal tubular cells, aldo-keto reductase was concordantly increased by glucose, and partially increased by albumin overload. Here, the combinatorial impact of two stressful agents in diabetes on the metabolome of kidney cells was investigated, revealing effects of glucose and albumin on polyol metabolism in human proximal tubular cells. This study shows the importance of including highly concentrated albumin in in vitro studies for mimicking diabetic kidney disease.
Pulsed Nanogenerator with Huge Instantaneous Output Power Density (2013)

A nanogenerator (NG) usually gives a high output voltage but low output current, so that the output power is low. In this paper, we developed a general approach that gives a hugely improved instantaneous output power of the NG, while the entire output energy stays the same. Our design is based on an off-on-off contact based switching during mechanical triggering that largely reduces the duration of the charging/discharge process, so that the instantaneous output current pulse is hugely improved without sacrificing the output voltage. For a vertical contact-separation mode triboelectric NG (TENG), the instantaneous output current and power peak can reach as high as 0.53 A and 142 W at a load of 500 Ω, respectively. The corresponding instantaneous output current and power density peak even approach 1325 A/m(2) and 3.6 × 10(5) W/m(2), which are more than 2500 and 1100 times higher than the previous records of TENG, respectively. For the rotation disk based TENG in the lateral sliding mode, the instantaneous output current and power density of 104 A/m(2) and 1.4 × 10(4) W/m(2) have been demonstrated at a frequency of 106.7 Hz. The approach presented here applies to both a piezoelectric NG and a triboelectric NG, and it is a major advance toward practical applications of a NG as a high pulsed power source.
Resistance Spot Welding between Aluminum Alloy and Low-Carbon Steel (2011)

Aluminum alloy A5052 and low-carbon steel (SPCC) was welded using resistance spot welding with a cover plate. The interfacial microstructure was observed using electron microscopy. A thick two-layered reaction layer contains Fe2Al5 and FeAl3was observed at the welding interface, respectively. Mechanical property analysis suggested that the reaction layer has no effect on the tensile shear strength of the A5052/SPCC joint and affects the cross tension strength of the joint.
Regulation of sterol synthesis in cultured cells by oxygenated derivatives of cholesterol (1975)

Sterol synthesis in liver in vivo is regulated at the site of the reaction catalyzed by 3-hydroxy-3-methylglutaryl-CoA reductase through a feedback system thought to involve either cholesterol or one or more of the products of its metabolism. Cholesterol feeding results in repression of the synthesis of the enzyme, but inactivation of the enzyme seems to precede repressroblasts is not inhibited by purified exogenous cholesterol. However, derivatives of cholesterol produced by the introduction of a ketone or hydroxyl function in the 7, 20, 22 or 25 positions effectively inhibit sterol synthesis by specifically depressing the level of HMG CoA reductase activity. As a result of this specific effect prolonged incubation of an inhibitory sterol with growing L cells results in depletion of cellular sterol. Growth of the culture then ceases and the cells die unless an appropriate sterol or a sterol precursor is supplied in the medium. The inhibitory sterols, 25-hydroxycholesterol and 7-ketocholesterol appear to be taken up by L cells through processes that involve their specific interactions with saturable cellular receptors. The uptake of cholesterol by L cells appears to be by a different process--possibly through physical diffusion.
Design and startup of an anaerobic fluidized bed reactor (1999)

A 10 1 anaerobic fluidized bed reactor (AFBR) was designed and constructed, using beach sand as the solid support for the biomass. Considering the complexity of this type of system, previously to the startup, several experiences were performed in a series of minireactors, such as: determination of the bed expansion and the feed distribution. The startup was made increasing gradually the organic load rate (OLR), using the alkalinity ratio (α) and the removal of the organic load, as mg/l of COD, as leading parameters. The system attained a COD removal of over 85%, for an OLR of 3.4 [kg COD/m3·d]. The best removal of 92% was obtained at an OLR of 1.04 [kg COD/m3·d], with a hydraulic retention time (HRT) of 12 hours. The best gas production of 1.8 [m3 of biogas/m3·d], equivalent to a production of 0.16 [m3/kg CODremoved], was obtained at an (HRT) of 4.8 hours. The best startup results were obtained using Ethanol as the Carbon source.
High-Efficiency Continuous-Wave Raman Laser Pumped by an Injection-Locked Broad-Area Diode Laser (2004)

We report an efficient CW far-off-resonance Raman laser in H/sub 2/ gas pumped by an injection-locked broad-area diode laser. The pump wavelength 794 nm is Raman shifted to the Stokes wavelength 1185 nm. The total output Stokes power reaches 21.6/spl plusmn/0.5 mW and the photon conversion efficiency reaches (74/spl plusmn/10)%.
Low-noise preamplifier for multistage photorefractive image amplification (1995)

We present a two-beam coupling configuration in photorefractive BaTiO(3) that provides a low-noise amplification of the signal to be detected. A two-wave mixing gain of 100 is reached, in conjunction with very low beam fanning background in the signal direction. The extensions of this configuration to photorefractive heterodyne detection and to multistage image amplif ication are theoretically and experimentally studied.
Surface passivation investigation on ultra-thin atomic layer deposited aluminum oxide layers for their potential application to form tunnel layer passivated contacts (2017)

10.7567/JJAP.56.08MB14
Total Synthesis of Amphidinolide X (2004)

A concise total synthesis of the cytotoxic marine natural product amphidinolide X (1) is described. A key step of the highly convergent route to this structurally rather unusual macrodiolide derivative consists of a newly developed, highly syn selective formation of allenol 6 by an iron-catalyzed ring opening reaction of the enantioenriched propargyl epoxide 5 (derived from a Sharpless epoxidation) with a Grignard reagent. Allenol 6 was then cyclized with the aid of Ag(I) to give dihydrofuran 7 containing the (R)-configured quarternary sp3 chiral center at C19 of the target. The anti-configured chiral centers at C10 and C11 were formed by the palladium-catalyzed, Et2Zn-promoted addition of propargyl mesylate 12 to the functionalized aldehyde 11. The key fragment coupling at the C13-C14 bond was achieved by the "9-MeO-9-BBN" variant of the alkyl-Suzuki reaction. Finally, the 16-membered macrodiolide ring was formed by a Yamaguchi esterification/lactonization strategy.
Direct interaction between polymorphonuclear neutrophils and cuprophan membranes in a plasma-free model of dialysis. (1985)

Plasma-free, purified, normal, human polymorphonuclear neutrophils (PMN) were recirculated for 60 minutes in an experimental model of dialysis using cuprophan membranes and acetate or bicarbonate dialysate. At different time intervals, the intracellular contents of PMN-derived cationic proteins (NCP), the release of lysosyme, beta-glucuronidase and PAF as well as the occurrence of PMN and platelet aggregating activities in the supernatants were evaluated. The formation of PMN aggregates, the depletion of intracellular contents of NCP together with the release of lysosomal constituents occurred early (5-10 min) in the course of recirculation. These events were concomitant with the occurrence of PMN aggregating activity in the supernatants due to the release of NCP, as it was antagonised (30-40%) by a rabbit anti-human NCP, and to the release of PAF which also accounted for the platelet aggregating activity that was independent from both adenosine diphosphate and cyclo-oxygenase inhibitors. These data suggest that direct interaction occurs between human PMN and cuprophan in in vitro conditions in the absence of plasma factors and point to a role for cellular mediators in the pathogenesis of the intravascular alterations occurring early in haemodialysis.
Structural ordering of the Plasmodium berghei circumsporozoite protein repeats by inhibitory antibody 3D11 (2020)

Plasmodium sporozoites express circumsporozoite protein (CSP) on their surface, an essential protein that contains central repeating motifs. Antibodies targeting this region can neutralize infection, and the partial efficacy of RTS,S/AS01 - the leading malaria vaccine against <i>P. falciparum</i> (Pf) - has been associated with the humoral response against the repeats. Although structural details of antibody recognition of PfCSP have recently emerged, the molecular basis of antibody-mediated inhibition of other Plasmodium species via CSP binding remains unclear. Here, we analyze the structure and molecular interactions of potent monoclonal antibody (mAb) 3D11 binding to <i>P. berghei</i> CSP (PbCSP) using molecular dynamics simulations, X-ray crystallography, and cryoEM. We reveal that mAb 3D11 can accommodate all subtle variances of the PbCSP repeating motifs, and, upon binding, induces structural ordering of PbCSP through homotypic interactions. Together, our findings uncover common mechanisms of antibody evolution in mammals against the CSP repeats of Plasmodium sporozoites.
Novel MODY3 Mutations in the Hepatocyte Nuclear Factor-1α Gene: Evidence for a Hyperexcitability of Pancreatic β-cells to Intravenous Secretagogues in a Glucose-Tolerant Carrier of a P447L Mutation (1997)

One form of maturity-onset diabetes of the young (MODY3) results from mutations in the hepatocyte nuclear factor (HNF)-1alpha gene, located on chromosome 12q24.2. The primary objective of the present study was to search for genetic variation in the HNF-1alpha gene in nine nonrelated Danish Caucasian subjects with MODY. Direct sequencing of the coding region and intron-exon boundaries of the HNF-1alpha gene revealed 2 novel and 1 previously reported missense mutations and 2 novel frameshift mutations in five of nine MODY subjects. These five mutations were found in neither 84 NIDDM patients nor 84 control subjects. One glucose-tolerant lean male with a P447L missense mutation, which in his relatives caused MODY, underwent an oral glucose tolerance test (OGTT), a tolbutamide modified frequently sampled intravenous glucose tolerance test, and a glucagon test to examine for a possible early beta-cell abnormality. He had a low insulin secretion rate during an OGTT, but a twofold increase in pancreatic beta-cell response after intravenous glucose and a 2.5- to 4-fold increase in beta-cell response after either intravenous tolbutamide or intravenous glucagon loads. In conclusion, 1) mutations in the HNF-1alpha gene are common in Danish Caucasian MODY patients, and 2) early stages in the pathogenesis of MODY3 caused by the P447L mutation may be characterized by a hyperexcitability of beta-cells to intravenous secretagogues.