gebhart/patrepeval huggingface dataset:
A single chip multistandard video codec (2002)

A programmable chip that implements multiple standards is described. Compliant with ISO MPEG (Moving Pictures Experts Group), it encodes or decodes SIF images at 30 frames/sec. It implements a P /spl times/ 64 full-duplex CIF codec at 15 frames/sec or QCIF at 30 frames/sec. It contains a glueless 80 Mbyte/sec DRAM (dynamic random-access memory) controller, a 240 MIPS (million instructions per second) SIMD (single instruction, multiple data) processor, and a 2000 MOPS (million operations per second) motion estimator. CCIR 601 video is input with high-quality conversion to SIF format, and a video display controller interpolates to 601 interlaced output.
The role of innate immune genes in Alzheimer's disease (2021)

Targeting neuroinflammation via CD33 inhibition and/or TREM2 activation may have important implications for neurodegeneration in Alzheimer's disease and may be an addition to monoclonal anti-Aβ antibody treatments that remove plaques without reducing neuroinflammation.
Potential Estimation of Load Alleviation and Future Technologies in Reducing Aircraft Structural Mass (2022)

In recent years, load alleviation technologies have been more widely used in transport aircraft. For aircraft already in service, load alleviation can contribute in extending the fatigue life, or enable small configurational changes. If load alleviation is considered in the aircraft design process, the structural mass of the aircraft can be reduced. This paper investigates various maneuver and gust load alleviation algorithms as well as potential future technologies regarding flight operation, turbulence forecast and material science, and it evaluates the mass reduction that can be achieved. In doing so, a long-range transport aircraft was taken as the reference, and the considered load case conditions were 1-cos gusts, maneuvers and quasi-steady landing. Based upon the loads, the composite structure of the lifting surfaces was optimized, while the secondary masses as well as the wing planform were kept unchanged. With all technologies implemented, a reduction of the wing box mass by 26.5% or 4.4% of the operating empty mass could be achieved.
Sargassum ilicifolium (Turner) C.Agardh’ın Spektral Analizi ve Kolon Kanseri (HT-29) ve Akciğer Kanseri (A549) Hücre Serilerine Karşı Etanolik Ekstre ve Kloroform Fraksiyonunun in vitro Anti-proliferatif Çalışması (2017)

Spectral Analysis of Sargassum ilicifolium (Turner) C. Agardh and in vitro Anti-proliferative Study of its Ethanolic Extract and Chloroform Fraction Against Colon Cancer (HT-29) and Lung Cancer (A549) Cell Lines. Current research in drug discovery from medicinal plants involves the identification of safe and inexpensive lead molecule towards diseases. Cancer is a second major national burden leading to cause death. Reducing the nation’s cancer burden is a great challenge to win the “War of cancer”. During the last decades, numerous novel compounds have been found from marine organisms with interesting pharmaceutical activities. Hence, a novel brown algae, Sargassum ilicifolium (Turner) C.Agardh belonging to Sargassaceae family has selected and the study was aimed to investigate the in vitro anti-proliferative activity of ethanolic extract and chloroform fraction of Sargassum ilicifolium (Turner) C.Agardh. against colon cancer (HT-29) and lung cancer (A549) cell lines. Extraction of seaweed using 70% ethanol and fractionated with various solvents. Based on phytochemical screening, chloroform fraction was selected, then it was subjected to GC-MS analysis. The 70% ethanolic exract and chloroform fraction were selected to in vitro MTT cell line assay using colon cancer cell line (HT-29) and lung cancer cell line (A549). The GC-MS analysis report confirmed the presence of 21 compounds and in the the invitro assay, IC50value showed the effective anti-proliferative activity against colon and lung cancer cell lines. The results of the present study proved the anti-proliferative effect of Sargassum ilicifolium. Further, the active biomolecule in the fraction has to be isolated and charecterized the formulated product subjected to in vivo study to strengthen the anticancer activity.
Comparison Between the Steady Performance of Double-Entry and Twin-Entry Turbocharger Turbines (2011)

Most boosting systems in internal combustion engines utilize ‘pulse turbocharging’ to maximize the energy extraction by the turbine. An internal combustion engine with more than four cylinders has a significant overlap between the exhaust pulses which, unless isolated, can decrease the overall pulse energy and increase the engine pumping loss. Thus, it is advantageous to isolate a set of cylinders and introduce the exhaust gases into two or more turbine entries separately. There are two main types of multiple entry turbines depending on the method of flow division: the twin-entry and the double-entry turbine. In the twin-entry design, each inlet feeds the entire circumference of the rotor leading edge regardless of inlet conditions. In contrast, the double-entry design introduces the flow from each gas inlet into the rotor leading edge through two distinct sectors of the nozzle. This paper compares the performance of a twin and double-entry mixed flow turbine. The turbines were tested at Imperial College for a range of steady-state flow conditions under equal and unequal admission conditions. The performance of the turbines was then evaluated and compared to one another. Based on experimental data, a method to calculate the mass flow under unequal admission from the full admission maps was also developed and validated against the test results.
Corneal Wound Healing and Nerve Morphology after Excimer Laser In Situ Keratomileusis in Human Eyes (1996)

The nerve morphology showed only a few abnormalities, especially in deep stromal nerves. Epithelial plugs at the flap margins may maintain a delayed wound healing process for several months but otherwise the process remained active for a relatively short time.
Repair of premutagenic DNA lesions in human fetal tissues: evidence for low levels of O6-methylguanine-DNA methyltransferase and uracil-DNA glycosylase activity in some tissues (1983)

The activities of the DNA repair enzymes O6-methylguanine-DNA methyltransferase and uracil-DNA glycosylase, and the replicative enzyme DNA polymerase alpha, were measured in extracts of human fetal tissues at 18-20 weeks of gestation. In general, O6-methylguanine-DNA methyltransferase activities in fetal tissues were in the same range as in the corresponding adult tissues, except for fetal liver which had approximately 5-fold lower activity. Uracil-DNA glycosylase was, surprisingly, approximately 4-fold lower in fetal tissues compared with adult tissues. Since a critical factor in carcinogenesis may be the rate of repair relative to DNA replication, the activities of O6-methylguanine-DNA methyltransferase and uracil-DNA glycosylase were compared with the DNA polymerase alpha activity in the same extract. When expressed in this way, O6-methylguanine-DNA methyltransferase activity was lowest in liver and brain and 2- to 14-fold higher in kidney, lung, colon, stomach, small intestine and pancreas. The ratio of uracil-DNA glycosylase to DNA polymerase alpha varied less between different organs. These findings indicate that several fetal organs may be more sensitive than adult organs to some alkylating agents that are known to occur in the environment. Furthermore, the lower capacity of DNA repair is not restricted to repair of alkylation damage, since the activity of uracil-DNA glycosylase is also lower than in adult tissues.
Re: A Prospective Comparative Analysis of Robot-Assisted vs Open Simple Prostatectomy for Benign Prostatic Hyperplasia (2019)

No AccessJournal of UrologyUrological Survey1 Jul 2019Re: A Prospective Comparative Analysis of Robot-Assisted vs Open Simple Prostatectomy for Benign Prostatic Hyperplasia Jeffrey A. CadedduMD Jeffrey A. CadedduJeffrey A. Cadeddu More articles by this author View All Author Informationhttps://doi.org/10.1097/01.JU.0000557733.32993.9aAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Re: A Prospective Comparative Analysis of Robot-Assisted vs Open Simple Prostatectomy for Benign Prostatic Hyperplasia." The Journal of Urology, 202(1), pp. 12–13 Suggested Reading : Robotic assisted simple prostatectomy versus holmium laser enucleation of the prostate for lower urinary tract symptoms in patients with large volume prostate: a comparative analysis from a high volume center. J Urol 2017; 197: 1108. Link, Google Scholar © 2019 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 202Issue 1July 2019Page: 12-13 Advertisement Copyright & Permissions© 2019 by American Urological Association Education and Research, Inc.MetricsAuthor Information Jeffrey A. Cadeddu More articles by this author Expand All Advertisement Loading ...
Pilot-Scale Examination of Mixing Liquid into Pulp Fiber Suspensions in the Presence of an In-Line Mechanical Mixer (2012)

The quality of liquid mixing into the main stream for an in-line mechanical mixer was investigated for water and pulp suspensions over a range of mass concentrations (0–3.0%), main-stream velocities (0.5–3.0 m/s), jet velocities (3.8–12.6 m/s), and rotational speeds (0–800 rpm) based on electrical resistance tomography and a modified mixing index, derived from the coefficient of variation of conductivity values. The mixing quality was worse when the jet penetrated to the far wall of the pipe for all fiber mass concentrations investigated, whereas this only applied at higher mass concentrations without the impeller. For water flow, the residence time had a significant effect on mixing at higher impeller speeds. With the impeller present, the mixing quality in pulp suspensions improved substantially and was similar to that for water when the flow approached the turbulent regime, with a considerably lower main-stream velocity required for mixing compared to a tee mixer alone. At higher mass concentrations, the energy supplied was insufficient to provide the same level of turbulence as that in water, even at the highest main-stream velocity and impeller speed examined. Improved mixing with increasing impeller speed primarily occurred in the high-shear zone around the impeller, with turbulence decaying rapidly downstream, likely aided by reflocculation.
Long-term effects of culture of preimplantation mouse embryos on behavior (2004)

Many procedures used in assisted reproductive technologies (ART) to treat human infertility entail culture of preimplantation embryos. Moreover, there is an increasing trend to culture embryos for longer periods of time before uterine transfer to identify the "best" embryos for transfer and to minimize multiple pregnancies. Embryo culture, however, can perturb embryo metabolism and gene expression, and the long-term consequences of culture are unknown. We have explored the behavioral consequences of embryo culture by using a 129S6/SvEvTac/C57BL/6J F(1) mouse model and find that adults derived from cultured embryos exhibit specific behavioral alterations in the elevated zero maze and Morris water maze tasks.
Review: Viruses and Bacteria (1999)

Book Review| October 01 1999 Review: Viruses and Bacteria Viruses and Bacteria Sara Blumenstein Sara Blumenstein Search for other works by this author on: This Site PubMed Google Scholar The American Biology Teacher (1999) 61 (8): 634–635. https://doi.org/10.2307/4450784 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Sara Blumenstein; Review: Viruses and Bacteria. The American Biology Teacher 1 October 1999; 61 (8): 634–635. doi: https://doi.org/10.2307/4450784 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentThe American Biology Teacher Search This content is only available via PDF. Copyright The National Association of Biology Teachers Article PDF first page preview Close Modal You do not currently have access to this content.
Numerical simulation of fatigue failure in carbon fibre reinforced aluminium alloy laminates (1999)

Hybrid laminates typically consist of alternate layers of fibre reinforced plastic and aluminium alloy. Developed for fatigue critical aerospace applications i.e. fuselage and lower wing skins, the hybrid laminates are orthotropic materials with lower density and higher strength compared to the alloy monolith. A remote sensing system reliant upon fibre optic technology has been developed to monitor the strain field encountered across composite laminae. This fibre optic system has been applied initially to the problem of characterising delamination zone development about a fatigue crack initiated at a through thickness fastener hole. Delamination measurements obtained using an in-situ ultrasonic C-scanner have been utilised in numerical simulations of the fatigue failure process and the data compared with measured strain profiles.
Optogenetic Stimulation of Peripheral Vagus Nerves using Flexible OLED Display Technology to Treat Chronic Inflammatory Disease and Mental Health Disorders (2016)

Abstract : This work explored the viability of a biophotonic alternative to conventional prescription-drug-based treatments for inflammatory disease and mental health disorders using a non-invasive drug-free optogenetics-based therapy that treats patients by optically stimulating afferent branches of the auricular vagus transcutaneously via the outer ear using a high-resolution, addressable array of organic light emitting diodes (OLEDs) manufactured on a flexible plastic substrate. Preliminary analysis and optical measurements indicate that our 620 nm flexible red OLED display technology is bright enough to induce therapeutic optical stimulation in optogenetically modified neural tissue.
Common Data Model for Neuroscience Data and Data Model Exchange (2001)

True federation of data resources requires explicit public description, in a metalanguage, of the contents, query methods, data formats, and data models of each data resource. Any data model that can be derived from the defined superclasses is potentially conformant and interoperability can be enabled by recognition of BDML-described compatibilities. Such metadescriptions can buffer technologic changes.
Repositioning disulfiram as a radiosensitizer against atypical teratoid/rhabdoid tumor (2016)

DSF and RT combination therapy has additive therapeutic effects on AT/RT by potentiating programmed cell death, including apoptosis and autophagy of AT/RT cells. We suggest that DSF can be applied as a radiosensitizer in AT/RT treatment.
Developing applications with a UIMS (1994)

A User Interface Management System (UIMS) is a collection of programs and libraries that enables an application to be partitioned into functionally distinct component parts. This partitioning recognizes that any application is comprised of three types of components, each encompassing a separate domain of expertise. These are the application domain, the display technology domain, and the user interface domain. By separating the application into dialogue utilizing a collection of agents, development time is reduced and maintainability is enhanced. Because the dialogue views the agents as black boxes, the benefits of parallel development and independent maintenance and upgrade are realized. Display technology agents can be easily reused, enabling a corporate look-and-feel. Further, an application agent can be reused with different user interfaces, creating systems tailored to different classes of users. We describe the general features of the Alpha UIMS, and show how a complete application can be developed using such a User Interface Management System.
Serum Levels of a Cathepsin-K Generated Periostin Fragment Predict Incident Low-Trauma Fractures in Postmenopausal Women Independently of BMD and FRAX (2017)

Periostin is a matricellular protein involved in bone formation and bone matrix organization, but it is also produced by other tissues. Its circulating levels have been weakly associated with bone microstructure and prevalent fractures, possibly because periostin measured by the current commercial assays does not specifically reflect bone metabolism. In this context, we developed a new ELISA for a periostin fragment resulting from cathepsin K digestion (K-Postn). We hypothesized that circulating K-Postn levels could be associated with bone fragility. A total of 695 women (age 65.0 ± 1.5 years), enrolled in the Geneva Retirees Cohort (GERICO), were prospectively evaluated over 4.7 ± 1.9 years for the occurrence of low-trauma fractures. At baseline, we measured serum periostin, K-Postn, and bone turnover markers (BTMs), distal radius and tibia microstructure by HR-pQCT, hip and lumbar spine aBMD by DXA, and estimated fracture probability using the Fracture Risk Assessment Tool (FRAX). Sixty-six women sustained a low-trauma clinical fracture during the follow-up. Total periostin was not associated with fractures (HR [95% CI] per SD: 1.19 [0.89 to 1.59], p = 0.24). In contrast, K-Postn was significantly higher in the fracture versus nonfracture group (57.5 ± 36.6 ng/mL versus 42.5 ± 23.4 ng/mL, p < 0.001) and associated with fracture risk (HR [95%CI] per SD: 2.14 [1.54 to 2.97], p < 0.001). After adjustment for aBMD, FRAX, bone microstructure, or BTMs, K-Postn remained significantly associated with fracture risk. The performance of the fracture prediction models was improved by adding K-Postn to aBMD or FRAX (Harrell C index for fracture: 0.70 for aBMD + K-Post versus 0.58 for aBMD alone, p = 0.001; 0.73 for FRAX + K-Postn versus 0.65 for FRAX alone, p = 0.005). Circulating K-Postn predicts incident fractures independently of BMD, BTMs, and FRAX in postmenopausal women. Hence measurement of a periostin fragment resulting from in vivo cathepsin K digestion may help to identify subjects at high risk of fracture. © 2017 American Society for Bone and Mineral Research.
"PERFECT": An Entirely New Methodology for Synthesizing Perfluorinated Compounds. (2003)

「PERFECT」を用いることにより, 以下のようなことが期待できる.(1) 骨格形成を通常の有機合成で行うので合成の自由度が飛躍的に向上し, 新しい有用なフッ素化合物の創出が可能になる.(2) フッ素化合物を原料とする既存の手法に比べ, 炭化水素化合物を原料とするのでフッ素化合物を安価に合成することも可能になる.(3) 目的物自身を溶媒とすることができ, 副生成物も本質的には水素だけであるので, 環境調和型の製造プロセス (グリーンプロセス) になる.現在, 旭硝子では「PERFECT」の工業化を目指して開発を行っている.
Searching for TrioNet: Combining Convolution with Local and Global Self-Attention (2021)

Recently, self-attention operators have shown superior performance as a stand-alone building block for vision models. However, existing self-attention models are often hand-designed, modified from CNNs, and obtained by stacking one operator only. A wider range of architecture space which combines different self-attention operators and convolution is rarely explored. In this paper, we explore this novel architecture space with weight-sharing Neural Architecture Search (NAS) algorithms. The result architecture is named TrioNet for combining convolution, local self-attention, and global (axial) self-attention operators. In order to effectively search in this huge architecture space, we propose Hierarchical Sampling for better training of the supernet. In addition, we propose a novel weight-sharing strategy, Multi-head Sharing, specifically for multi-head self-attention operators. Our searched TrioNet that combines self-attention and convolution outperforms all stand-alone models with fewer FLOPs on ImageNet classification where self-attention performs better than convolution. Furthermore, on various small datasets, we observe inferior performance for self-attention models, but our TrioNet is still able to match the best operator, convolution in this case. Our code is available at https://github.com/phj128/TrioNet.
Formal and Compositional Analysis of Power Systems Using Reachable Sets (2014)

Power system stability analysis becomes more important in the presence of ever increasing variations in operating conditions. Traditionally, the operation of power systems is verified for specific operating conditions. In this work, the stability analysis is performed for a set of operating conditions using reachability analysis, which makes it possible to compute the bounds of all possible system trajectories. Thus, reachability analysis can be used to rigorously check specifications. Contrary to previous work, the presented approach does not require model simplifications when the system is described by semi-explicit, nonlinear, index-1 differential-algebraic equations. The main obstacle in reachability analysis is the scalability towards larger systems, which is addressed by investigating compositional techniques. As a result, transient stability and variable energy production can be analyzed for the IEEE 14-bus and 30-bus benchmark systems, for which the computation times are orders of magnitude faster than the simulation of all cases starting in the corners of the set of possible initial states.
RetroGNN: Fast Estimation of Synthesizability for Virtual Screening and De Novo Design by Learning from Slow Retrosynthesis Software (2022)

De novo molecule design algorithms often result in chemically unfeasible or synthetically inaccessible molecules. A natural idea to mitigate this problem is to bias these algorithms toward more easily synthesizable molecules using a proxy score for synthetic accessibility. However, using currently available proxies can still result in highly unrealistic compounds. Here, we propose a novel approach, RetroGNN, to estimate synthesizability. First, we search for routes using synthesis planning software for a large number of random molecules. This information is then used to train a graph neural network to predict the outcome of the synthesis planner given the target molecule, in which the regression task can be used as a synthesizability scorer. We highlight how RetroGNN can be used in generative molecule-discovery pipelines together with other scoring functions. We evaluate our approach on several QSAR-based molecule design benchmarks, for which we find synthesizable molecules with state-of-the-art scores. Compared to the virtual screening of 5 million existing molecules from the ZINC database, using RetroGNNScore with a simple fragment-based de novo design algorithm finds molecules predicted to be more likely to possess the desired activity exponentially faster, while maintaining good druglike properties and being easier to synthesize. Importantly, our deep neural network can successfully filter out hard to synthesize molecules while achieving a 10<sup>5</sup> times speedup over using retrosynthesis planning software.
Intergrowth Structures in Superconductor Tl-Ba-Ca-Cu-O Oxides (1988)

Direct read-out of metal atom coordinates from HREM images was performed on superconductive Tl-Ba-Ca-Cu-O (TBCCO) oxide crystals. The technique permits examination, in a quantitative fashion, of crystal structures including stacking disorders. Some ordered intergrowth structure for TBCCO oxides, beside the Tl 2 Ba 2 CaCu 2 O 8+ x (2212) and Tl 2 Ba 2 Ca 2 Cu 3 O 10+ x (2223) phases, were observed, and their structure were identified as sequences of structure with a single Tl-O sheet instead of double Tl 2 O 2 sheets, a chemical formula TlBa 2 Ca 2 Cu 3 O 9+ x , has been confirmed.