gebhart/patrepeval huggingface dataset:
Expression of sentrin, a novel antiapoptotic molecule, at sites of synovial invasion in rheumatoid arthritis (2000)

The marked expression of sentrin in rheumatoid synovial tissue, but not in normal or OA synovial tissue, may contribute to the modulation of Fas- and TNFR-mediated apoptosis in RA synovium, and thereby extend the lifespan of invasive, cartilage-destructive SF.
사례연구 : 애착장애 아동의 부모 집단 심리치료 사례 - 부모 상담을 중심으로 - (2001)

본 연구는 애착장애 아동을 가진 어머니를 대상으로 부모 집단 심리치료를 실시하는 것이 매우 효과적임을 알리고자 실시되었다. 된 연구를 위해 다섯 쌍외 애착장애 아동-어머니가 참여하였다. 그 중 하나의 사례를 좀더 구체적으로 소개하고자 한다. 본 연구에서는 애착에 영향을 미치는 어머니 요소에 초점을 맞추어, 어머니의 행동적 수준과 표상적 수준의 변화를 꾀하고자 개발된 13회기에 걸친 심리치료 프로그램을 집단으로 실시하였다. 그 결과, 어머니의 아동에 대한 표상이 긍정적으로 변화하였으며, 어머니-아동 상호작용 점수가 상승하였다. 특히 침해성, 주의, 민감성, 반응성 점수에서 상승을 보였다. 아동 역시 발달에 있어 개인성 및 사회성, 언어성, 미세운동, 전체운동 영역에서 향상되었다. 즉, 본 사례의 어머니는 집단 심리치료 참여 전에 비하여 참여 후에 아동에 대한 표상과 상호작용에 긍정적인 변화를 나타냈다.
Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations (1999)

The Notch family of proteins consists of transmembrane receptors that play a critical role in the determination of cell fate. Genetic studies in Caenorhabditis elegans suggest that the presenilin proteins, which are associated with familial Alzheimer's disease, regulate Notch signaling. Here we show that proteolytic release of the Notch-1 intracellular domain (NICD), an essential step in the activation of Notch signaling, is markedly reduced in presenilin-1 (PS1)-deficient cells and is restored by PS1 expression. Nuclear translocation of the NICD is also markedly reduced in PS1-deficient cells, resulting in reduced transcriptional activation. Mutations in PS1 that are associated with familial Alzheimer's disease impair the ability of PS1 to induce proteolytic release of the NICD and nuclear translocation of the cleaved protein. These results suggest that PS1 plays a central role in the proteolytic activation of the Notch-1-signaling pathway and that this function is impaired by pathogenic PS1 mutations. Thus, dysregulation of proteolytic function may underlie the mechanism by which presenilin mutations cause Alzheimer's disease.
The regulatory roles of glycosphingolipid‐enriched lipid rafts in immune systems (2018)

Lipid rafts formed by glycosphingolipids (GSLs) on cellular membranes play important roles in innate and adaptive immunity. Lactosylceramide (LacCer) forms lipid rafts on plasma and granular membranes of human neutrophils. These LacCer-enriched lipid rafts bind directly to pathogenic components, such as pathogenic fungi-derived β-glucan and Mycobacteria-derived lipoarabinomannan via carbohydrate-carbohydrate interactions, and mediate innate immune responses to these pathogens. In contrast, a-series and o-series gangliosides form distinct rafts on CD4<sup>+</sup> and CD8<sup>+</sup> T cell subsets, respectively, contributing to the respective functions of these cells and stimulating adaptive immune responses through T cell receptors. These findings suggest that gangliosides play indispensable roles in T cell selection and activation. This Review introduces the involvement of GSL-enriched lipid rafts in innate and adaptive immunity.
Human MICL (CLEC12A) is differentially glycosylated and is down‐regulated following cellular activation (2006)

C-type lectins are the most diverse and prevalent lectin family in immunity. Particular interest has recently been attracted by the C-type lectin-like receptors on NK cells, which appear to regulate the activation/inhibitory balance of these cells, controlling cytotoxicity and cytokine production. We previously identified a human C-type lectin-like receptor, closely related to both the beta-glucan receptor and the lectin-like receptor for oxidized-LDL, named MICL (myeloid inhibitory C-type lectin-like receptor), which we had shown using chimeric analysis to function as an inhibitory receptor. Using a novel MICL-specific monoclonal antibody, we show here that human MICL is expressed primarily on myeloid cells, including granulocytes, monocytes, macrophages, and dendritic cells. Although MICL was highly N-glycosylated in primary cells, the level of glycosylation was found to vary between cell types. MICL surface expression was down-regulated during inflammatory/activation conditions in vitro, as well as during an in vivo model of acute inflammation, which we characterize here. This suggests that human MICL may be involved in the control of myeloid cell activation during inflammation.
Efficient DSP and Circuit Architectures for Massive MIMO: State of the Art and Future Directions (2018)

Massive MIMO is a compelling wireless access concept that relies on the use of an excess number of base-station antennas, relative to the number of active terminals. This technology is a main component of 5G New Radio and addresses all important requirements of future wireless standards: a great capacity increase, the support of many simultaneous users, and improvement in energy efficiency. Massive MIMO requires the simultaneous processing of signals from many antenna chains, and computational operations on large matrices. The complexity of the digital processing has been viewed as a fundamental obstacle to the feasibility of Massive MIMO in the past. Recent advances on system-algorithm-hardware co-design have led to extremely energy-efficient implementations. These exploit opportunities in deeply-scaled silicon technologies and perform partly distributed processing to cope with the bottlenecks encountered in the interconnection of many signals. For example, prototype ASIC implementations have demonstrated zero-forcing precoding in real time at a 55 mW power consumption (20 MHz bandwidth, 128 antennas, and multiplexing of 8 terminals). Coarse and even error-prone digital processing in the antenna paths permits a reduction of consumption with a factor of 2 to 5. This article summarizes the fundamental technical contributions to efficient digital signal processing for Massive MIMO. The opportunities and constraints on operating on low-complexity RF and analog hardware chains are clarified. It illustrates how terminals can benefit from improved energy efficiency. The status of technology and real-life prototypes discussed. Open challenges and directions for future research are suggested.
Neutron Scattering Investigation of the Magnetic Excitations in CoBr2 (1980)

In order to investigate the two-dimensionality and the easy plane anisotropy, the spin waves propagating along the [h, 0, 0], [h, h, 0], [h, 0.5h, 0] and [0, 0, l ] directions in CoBr 2 were observed using inelastic neutron scattering technique. The spin dynamics of CoBr 2 can be described by the anisotropic exchange Hamiltonian for S =1/2 with intraplanar exchange constants J 1 =2.01 meV, J 2 =0.019 meV and J 3 =-0.338 meV, interplanar exchange J '=-0.97 meV, and planar anisotropies D 1 =1.14 meV and D '=-0.06 meV. As shown by these numerical values, CoBr 2 has fairly strong XY characters, but the two-dimensionality is definitely poor. We point out, however, that in a planar antiferromagnet, the easy plane type anisotropy should remove the degeneracy of the excitation spectrum for the `in-plane' and the `out-of-plane' correlations, and in fact, these excitations are observed separately in this experiment.
Toward a paradigm shift from deficit-based to proactive speech and language treatment: Randomized pilot trial of the Babble Boot Camp in infants with classic galactosemia (2020)

<b>Background:</b> Speech and language therapy is typically initiated reactively after a child shows delays. Infants with classic galactosemia (CG), a metabolic disease with a known high risk for both speech and language disorders, hold the keys towards evaluating whether preventive treatment is effective when the risks are known at birth. We present pilot data from a randomized parallel trial of an innovative proactive speech and language intervention program, the Babble Boot Camp (BBC). <b>Method</b>: Five children with CG, otherwise healthy, participated in the study from approximately 2 to 24 months of age. One of these was randomly selected as control receiving conventional management, which typically starts at age 2-3 years. A pediatric speech-language pathologist met weekly via telepractice with the parents in the treatment cohort. Parents implemented the prespeech, speech, and language stimulation and expansion activities according to the intervention protocol. The control child was still too young for conventional treatment. Primary outcome measures were speech sound production complexity in babble and speech and expressive vocabulary size. Secondary outcome measures were vocalization rates and developmental milestones in communication, motor, and cognition. The trial is ongoing. <b>Results</b>: All four treated children had higher speech sound skills in babble, three had higher speech sound skills in meaningful speech, two had higher expressive vocabularies, three had higher global developmental scores, and two had higher vocalization rates, compared to the control child with CG. <b>Discussion:</b> Given the high risk for speech and language delays in children with CG, finding on-schedule abilities in two or more of the treated children but not the untreated child is unexpected under random conditions. The trends toward beneficial effects of the BBC on speech sound production, expressive language, and communication milestones warrant appropriately powered larger clinical trials with full randomization. <b>Trial registration:</b> ClinicalTrials.gov NCT03838016 (12 <sup>th</sup> February 2019).
Unslotted 1- and p/sub i/-persistent CSMA-CD protocols for fiber optic bus networks (1994)

Analyzes the performance of the unslotted 1-persistent carrier sense multiple access with collision detection (CSMA-CD) protocol for fiber optic bus networks with a finite number of stations M, each of which has an infinite storage buffer for storing packets with its length fixed or exponentially distributed. Treating the bus network as an M-class priority queueing system with a preemptive repeat-identical retransmission strategy, the authors show numerically that this 1-persistent retransmission strategy provides better delay-throughput performance than the non-persistent one. To satisfy the fairness of equal delays among stations in the bus network, the authors next present the unslotted p/sub i/-persistent CSMA-CD protocol. Under this protocol, the first packet arriving at station i is forced to enter into the backoff procedure with the probability of (1/spl minus/p/sub i/). After backoffs, transmission begins until the station becomes empty. The authors determine the persistent probability p/sub i/ and show that the delay-throughput performance of the p/sub i/-persistent strategy is better than that of the 1-persistent one, and further it is robust for any packet lengths. Simulation results are presented to verify the analytical results.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Elevated progesterone receptor membrane component 1/sigma‐2 receptor levels in lung tumors and plasma from lung cancer patients (2011)

Cancer is one of the leading causes of death, and there is an urgent need for new biomarkers and therapeutic targets. The progesterone receptor membrane component 1 (Pgrmc1) protein is upregulated in multiple types of cancer, and Pgrmc1 is required for tumor cell proliferation, motility and tumor formation in vivo. Furthermore, a small molecule inhibitor of Pgrmc1 suppressed the growth of lung, breast and cervical cancer cell lines. Recently, Pgrmc1 was identified as the sigma-2 receptor, a putative type of opioid receptor, and sigma-2 receptors are induced in cancers. However, Pgrmc1 shares no homology with known opioid or hormone receptors but is related to cytochrome b(5), and Pgrmc1 binds to heme and has reducing activity. In this study, we have analyzed Pgrmc1 levels in clinical tumor samples from squamous cell lung cancers (SCLC) and lung adenocarcinomas compared to corresponding nonmalignant tissue. Pgrmc1 levels increased significantly (p ≤ 0.05) in 12/15 SCLC samples and was elevated in poorly differentiated tumors. Pgrmc1 was highly expressed in SCLC cell lines, and SCLC cell survival was inhibited by siRNA knockdown of Pgrmc1 or the Pgrmc1 inhibitor AG-205. In adenocarcinomas, 6/15 tumors significantly had elevated Pgrmc1 levels, which correlated with patient survival. Pgrmc1 localizes to secretory vesicles in cancer cells, and Pgrmc1 was secreted by lung cancer cells. Furthermore, Pgrmc1 was significantly elevated in the plasma of lung cancer patients compared to noncancer patients. Together, the results demonstrate that Pgrmc1 is a potential tumor and serum biomarker, as well as a therapeutic target, for lung cancer.
Performance Analysis and Model-Free Design of Deracemization via Temperature Cycles (2020)

Solid-state deracemization via temperature cycles is a technique that has been shown to be effective to isolate the pure enantiomer of a conglomerate-forming compound. This process has a large number of operating parameters that can be adjusted according to system-specific properties. On the one hand, this feature makes the process flexible and prone to optimization. On the other hand, the design space is so large that experimental optimization of the process can become long and cumbersome. In this work, we achieve two results. First, we show that deracemization via temperature cycles works very effectively for two new experimental systems, namely, the chiral compounds 2-(benzylideneamino)-2-(2-chlorophenyl)acetamide (CPG) and 3,3-dimethyl-2-((naphthalen-2-ylmethylene)amino)butanenitrile (tLEU). Second, we propose a new approach for the design of an effective deracemization process via temperature cycles for a new compound. Therefore, in this work, we investigate the effect of different operating conditions, namely, the initial enantiomeric excess, the cooling rate, the temperature range, and the catalyst concentration, on the performance of deracemization via temperature cycles for the new compounds CPG and tLEU and for N-(2-methylbenzylidene)phenylglycine amide (NMPA), which was already studied in a previous paper. On the basis of these outcomes, we conclude by proposing a model-free screening strategy for the design of an effective deracemization process via temperature cycles for a new compound.
Factors Affecting Stability of Aqueous Potassium Ferrate(VI) Solutions (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFactors Affecting Stability of Aqueous Potassium Ferrate(VI) SolutionsW. F. Wagner, J. R. Gump, and E. N. HartCite this: Anal. Chem. 1952, 24, 9, 1497–1498Publication Date (Print):September 24, 1952Publication History Published online1 May 2002Published inissue 24 September 1952https://pubs.acs.org/doi/10.1021/ac60069a037https://doi.org/10.1021/ac60069a037research-articleACS PublicationsRequest reuse permissionsArticle Views481Altmetric-Citations58LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Erythro/Threo Ratio of β-O-4 Structures as an Important Structural Characteristic of Lignin. Part 2. Changes in Erythro/Threo (E/T) Ratio of β-O-4 Structures during Delignification Reactions (2002)

Summary The ozonation method was applied to an analysis of the changes in erythro and threo (E/T) ratio of arylglycerol-β-aryl ether (β-O-4) structures in the residual lignins of delignified wood samples. When delignified by alkali cook, not only the total yield of erythronic and threonic acids per lignin decreased, but also the E/T ratio decreased with the progress of delignification. These results indicate that residual lignin of alkali-delignified wood contain only a small amount of arylglycerol-β-aryl ether structures and/or glycerol side chains, which are relatively rich in the threo form. A suggested reason for this, in addition to the stereo-preferential degradation of the erythro β-O-4 structure, is the increasing contribution of topologically-inert lignin and/or chemically-inert lignin structures with a low original E/T ratio. In contrast, when the wood samples are delignified by NaClO 2 treatment, no significant change is observed in the E/T ratio. This confirms that the NaClO 2 delignification proceeds without the residual lignin retaining special configurational characteristics in its side chains.
ChemInform Abstract: Synthesis and Spectroscopic Properties of Benzo‐ and Naphthofuryl‐3‐hydroxychromones (IV). (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Non‐glycosidic Azides of D‐Altro‐ and D‐Gulopyranose. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
LOG-CONCAVITY OF COMPOUND DISTRIBUTIONS WITH APPLICATIONS IN OPERATIONAL AND ACTUARIAL MODELS (2019)

Abstract We establish that a random sum of independent and identically distributed (i.i.d.) random quantities has a log-concave cumulative distribution function (cdf) if (i) the random number of terms in the sum has a log-concave probability mass function (pmf) and (ii) the distribution of the i.i.d. terms has a non-increasing density function (when continuous) or a non-increasing pmf (when discrete). We illustrate the usefulness of this result using a standard actuarial risk model and a replacement model. We apply this fundamental result to establish that a compound renewal process observed during a random time interval has a log-concave cdf if the observation time interval and the inter-renewal time distribution have log-concave densities, while the compounding distribution has a decreasing density or pmf. We use this second result to establish the optimality of a so-called (s,S) policy for various inventory models with a stock-out cost coefficient of dimension [$/unit], significantly generalizing the conditions for the demand and leadtime processes, in conjunction with the cost structure in these models. We also identify the implications of our results for various algorithmic approaches to compute optimal policy parameters.
Meeting delay constraints in DSM by minimal repeater insertion (2000)

We address the problem of inserting repeaters, selected from a library, at feasible locations in a placed and routed network to meet user-specified delay constraints. We use minimal repeater area by taking advantage of slacks available in the network. Specifically, we transform the problem into an unconstrained optimization problem and solve it by iterative local refinement. We show that the optimal repeater locations and sizes that locally minimize the objective function in the unconstrained problem can be efficiently computed. We have implemented our algorithm and tested it on a set of benchmarks; experimental results are promising.
Transport of choline by plasma membrane vesicles from lung-derived epithelial cells (1992)

A549 cells, a lung epithelium-derived cell line, were used as a model system to study choline transport by granular pneumocytes. Intact cells accumulated free choline against a concentration gradient by a low-affinity transport system with kinetic characteristics similar to that previously described for granular pneumocytes (Am. J. Respir. Cell Mol. Biol. 1: 455, 1989). Membrane vesicles prepared from these cells showed a 10-fold enrichment in plasma membrane marker enzymes with a vesicular H2O space of 5.7 +/- 0.05 (SE) microliters/mg protein. Vesicles showed a time- and concentration-dependent uptake of free [3H]choline in Na(+)-free medium. With 5 microM choline, choline uptake reached an apparent steady-state concentration gradient (inside/outside) of 50. 3H that was membrane associated ("bound" choline) represented approximately 5% of total uptake. In the presence of an initial gradient of NaCl, choline uptake showed an overshoot with a plateau value similar to Na(+)-free conditions; a similar effect was observed for plasma membrane vesicles from rat lung type 2 epithelial cells. The steady-state uptake of choline was inhibited at low pH (6.5) and by the presence of valinomycin or carbonyl cyanide p-tri-fluoromethoxyphenylhydrazone and was abolished when both were present. These results show that plasma membrane vesicles from A549 cells accumulate choline by binding to the membranes and by Na(+)-dependent and -independent transport mechanisms, the latter apparently reflecting a transmembrane proton gradient.
A domain of the hepadnavirus capsid protein is specifically required for DNA maturation and virus assembly (1991)

Mutations introduced into the capsid gene of duck hepatitis B virus (DHBV) were tested for their effects on viral DNA synthesis and assembly of enveloped viruses. Four classes of mutant phenotypes were observed among a series of deletions of covering the 3' end of the capsid open reading frame. Class I mutant capsids were able to support normal single-stranded and relaxed circular viral DNA synthesis; class II mutant capsids supported normal single-stranded DNA synthesis but not relaxed circular DNA synthesis; class III mutant capsids resembled class II capsids, but viral DNA synthesis was inhibited 5- to 10-fold; and class IV capsids were severely restricted in their ability to support viral DNA synthesis. Class I capsids were assembled into enveloped virions, but class II, III, and IV capsids were not. Viral DNA synthesized inside class II capsids was normal with respect to minus-strand DNA initiation, plus-strand DNA initiation, and circularization of the DNA, but plus strands failed to be elongated to mature 3-kb DNA. The results suggest that a function of the capsid protein specifically required for viral DNA maturation is also required for assembly of nucleocapsids into envelopes. Thus, class II mutants appear to be defective in the appearance of the "packaging signal" for virus assembly (J. Summers and W. Mason, Cell 29:403-415, 1982).