gebhart/patrepeval huggingface dataset:
(Invited) Design of Nanostructured Materials By Electrochemical Approaches (2021)

The discovery of nanostructured materials led to ground-breaking findings and significant technological advancement in recent years and is therefore attracting continuous attention from both, academia, and industry for a variety of structural and functional applications [1]. To design nanostructured materials with new functionalities, we combine electrochemical and electroless chemical synthesis with structural studies on different length scales including transmission electron microscopy. The possibility to produce nanostructured metals containing nanoscaled twins, both growth twins and deformation twins, is considered as a promising approach for the synthesis of novel high-performance materials in recent years [1]. Unfortunately, the phenomenon of twinning occurs only in certain metals, such as copper and until recently, it seemed impossible to make aluminium with a high density of grown-in twins. In the present work, we demonstrate the use of electrodeposition as synthesis method to make Al layers with a high density of genuine growth twins [2]. This unexpected result demonstrates a versatile and cost-effective nanoengineering technique for the formation of pure Al layers with a high density of twins. The atomic structure of a twin in aluminium is shown in a transmission electron microscopy image (cf. Fig. 1). In high density, these symmetric lattice imperfections can yield a material that shows good electrical properties, high hardness and good deformability. In addition, we show that electrochemical synthesis approaches can be used to create high surface area functionalized foams and ordered nanostructures for potential sensing and energy-related applications [3-6].
Substance P via NK1receptor facilitates hyperactive bladder afferent signaling via action of ROS (2003)

We explored whether substance P (SP) via neurokinin (NK) receptor facilitates bladder afferent signaling and reactive oxygen species (ROS) formation in bladder in association with neurogenic inflammation. We evaluated ROS activity and cystometrograms as well as pelvic nervous activity in anesthetized rat bladder with SP stimulation. Our results showed that endogenous SP via NK(1), not NK(2), receptor mediated a micturition reflex. An increase in SP by electrical stimulation of the pelvic nerve or an increase in exogenous SP by intra-arterial or intrathecal administration can facilitate myogenic and neurogenic bladder contractions. Furthermore, exaggerated SP release increased ROS in the bladder and whole blood via increased mast cell degranulation, intercellular adhesion molecule expression, and leukocyte adhesion, a primary source of ROS in the inflamed bladder. Treatment with NK(1)-receptor antagonists or ROS scavengers reduced bladder intercellular adhesion molecule expression and ROS and ameliorated the hyperactive bladder response. Our study indicates that the mechanism by which SP participates in the neurogenic bladder may be complicated by its proinflammatory activity and its ability to stimulate ROS generation.
In-Frame and Unmarked Gene Deletions in Burkholderia cenocepacia via an Allelic Exchange System Compatible with Gateway Technology (2015)

Burkholderia cenocepacia is an emerging opportunistic pathogen causing life-threatening infections in immunocompromised individuals and in patients with cystic fibrosis, which are often difficult, if not impossible, to treat. Understanding the genetic basis of virulence in this emerging pathogen is important for the development of novel treatment regimes. Generation of deletion mutations in genes predicted to encode virulence determinants is fundamental to investigating the mechanisms of pathogenesis. However, there is a lack of appropriate selectable and counterselectable markers for use in B. cenocepacia, making its genetic manipulation problematic. Here we describe a Gateway-compatible allelic exchange system based on the counterselectable pheS gene and the I-SceI homing endonuclease. This system provides efficiency in cloning homology regions of target genes and allows the generation of precise and unmarked gene deletions in B. cenocepacia. As a proof of concept, we demonstrate its utility by deleting the Bcam1349 gene, encoding a cyclic di-GMP (c-di-GMP)-responsive regulator protein important for biofilm formation.
ChemInform Abstract: X=Y‐ZH Systems as Potential 1,3‐Dipoles. Part 39. Metallo‐Azomethine Ylides from Aliphatic Aldimines. Facile Regio‐ and Stereospecific Cycloaddition Reactions. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Pharmacological profile of alminoprofen among four writhing models of mice caused by kaolin, zymosan, acetylcholine and phenylquinone. (1990)

The effects of alminoprofen and other non-steroidal antiinflammatory drugs (NSAIDs) on the writhing reaction caused by kaolin, acetylcholine, phenylquinone and zymosan were studied. Aspirin, indomethacin, ibuprofen and diclofenac-Na, as cyclooxygenase inhibitors, showed similar potency ratios on four writhing tests, although, alminoprofen exhibited a somewhat rather higher potency ratio on kaolin- and zymosan-induced writhing models than on acetylcholine- and phenylquinone-induced writhing models. All NSAIDs, cyclooxygenase inhibitors except alminoprofen showed similar shapes in illustrations of potency ratio when the potency of aspirin was expressed as 1.0. The potency of alminoprofen produced a figure unlike those of other cyclooxygenase inhibitors. These results suggest that alminoprofen has a different pharmacological profile from other general NSAIDs in terms of analgesic action. This combination method with potency ratios for writhing reactions caused by the above four inducers could be a simple method for classification of pharmacological profiles of the analgesic actions of NSAIDs.
An investigation of conduction mechanisms at high-field in PET (2002)

The high-field electrical conduction, up to 60 kV/mm, of PET films is investigated in this paper. The behavior of time-to-peak, observed in transient charging current, vs electrical field fits well with the SCLC model, showing a power relationship. An exponential law is obtained between time-to-peak and temperature. Steady state regime provides charging-current density vs. electrical field plots which show clear transition from an ohmic behavior, at low field, to the SCLC mechanism. The threshold for this transition is a function of temperature.
<title>Projective Fourier analysis in computer vision: theory and computer simulations</title> (1997)

Identifying the projective group for patterns by developing the camera model, the projective Fourier transform and its inverse are obtained in analogy with the classical, that is, Euclidean Fourier analysis. Projectively adapted properties are demonstrated in a numerical test. Using the expression of the projective Fourier integral by a standard Fourier integral in the coordinates given by the complex principal logarithm, the discrete projective Fourier transform and its inverse are constructed showing that FFT algorithms can be adapted for their computations.
An Efficient Channel Allocation Scheme for Multicast Traffic in Multitier Cellular Systems (2001)

In this letter, we propose an efficient channel allocation scheme to provide multicast traffic in multitier cellular systems. Our proposed scheme allocates microcell/macrocell channels based on the &apos;microcell-group size&apos; and probability. Also, we analyze the performance of the scheme in view of the call blocking probalility in case of considering overflow traffic or not. Numerical results show that our proposed scheme exhibits: a better performance than conventional schemes.
Multi-Element Transducer Dedicated to Quantitative Acoustic Microscopy Imaging (2017)

International audience
A FPGA-based custom computing system for solving the assignment problem (2002)

The assignment problem is a classical combinatorial optimization problem arising in numerous design and planning contexts. Solving an assignment problem of large scale is computationally intensive and time consuming. The paper discusses the development of an FPGA based custom computing system that can accelerate the computation by exploiting the intrinsic parallelism of a recently proposed recurrent neural network for solving the assignment problem. The theoretical background of this work has been discussed in other papers. The digital realization of the system, including architecture, design, FPGA implementation and verification are discussed.
Pin1 Associates with and Induces Translocation of CRTC2 to the Cytosol, Thereby Suppressing cAMP-responsive Element Transcriptional Activity* (2010)

Pin1 is a unique regulator, which catalyzes the conversion of a specific phospho-Ser/Thr-Pro-containing motif in target proteins. Herein, we identified CRTC2 as a Pin1-binding protein by overexpressing Pin1 with Myc and FLAG tags in mouse livers and subsequent purification of the complex containing Pin1. The association between Pin1 and CRTC2 was observed not only in overexpression experiments but also endogenously in the mouse liver. Interestingly, Ser(136) in the nuclear localization signal of CRTC2 was shown to be involved in the association with Pin1. Pin1 overexpression in HepG2 cells attenuated forskolin-induced nuclear localization of CRTC2 and cAMP-responsive element (CRE) transcriptional activity, whereas gene knockdown of Pin1 by siRNA enhanced both. Pin1 also associated with CRTC1, leading to their cytosol localization, essentially similar to the action of CRTC2. Furthermore, it was shown that CRTC2 associated with Pin1 did not bind to CREB. Taken together, these observations indicate the association of Pin1 with CRTC2 to decrease the nuclear CBP·CRTC·CREB complex. Indeed, adenoviral gene transfer of Pin1 into diabetic mice improved hyperglycemia in conjunction with normalizing phosphoenolpyruvate carboxykinase mRNA expression levels, which is regulated by CRE transcriptional activity. In conclusion, Pin1 regulates CRE transcriptional activity, by associating with CRTC1 or CRTC2.
Secondary Beam Targetry Developments (1967)

Two recently developed target manipulators have increased the versatility of remote multitargeting in the production of secondary particles from within the Argonne Zero Gradient Synchrotron (ZGS). The Mark II manipulator is constructed in modular form to facilitate assembly in one of four arm-swing configurations. This allows new coverage patterns for the three to four manipulator combinations that can multitarget on a single synchrotron pulse. It also provides for quick, accurate target changes by replacement of a complete presurveyed arm and target assembly. A current pulsed coil, reacting with the guide field, thrusts the target of the Mark IV manipulator upwards from the bottom of the beam chamber. The Mark IV compact design permits close targeting positions between manipulators. The manipulator provides distinct target movements in each of the three coordinate axes (X, Y, and Z), as well as rotation in the XZ plane. This enhances automatic target positioning control. An exact replica of the 32-in x 70-in meson targeting area has been used for positional presurveys of meson targets and for the calibration of their positional readout systems. This use has greatly reduced radiation exposure to personnel and contributed substantially towards a 50% reduction in the ZGS maintenance time.
Non-Amidine-Containing 1,2-Dibenzamidobenzene Inhibitors of Human Factor Xa with Potent Anticoagulant and Antithrombotic Activity (2000)

ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTNon-Amidine-Containing 1,2-Dibenzamidobenzene Inhibitors of Human Factor Xa with Potent Anticoagulant and Antithrombotic ActivityJohn J. Masters, Jeffry B. Franciskovich, Jennifer M. Tinsley, Charles Campbell, Jack B. Campbell, Trelia J. Craft, Larry L. Froelich, Donetta S. Gifford-Moore, Lynne A. Hay, David K. Herron, Valentine J. Klimkowski, Kenneth D. Kurz, James T. Metz, Andrew M. Ratz, Robert T. Shuman, Gerald F. Smith, Tommy Smith, Richard D. Towner, Michael R. Wiley, Alex Wilson, and Ying K. YeeView Author Information Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285 Cite this: J. Med. Chem. 2000, 43, 11, 2087–2092Publication Date (Web):May 12, 2000Publication History Received23 December 1999Published online12 May 2000Published inissue 1 June 2000https://pubs.acs.org/doi/10.1021/jm990625bhttps://doi.org/10.1021/jm990625brapid-communicationACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views660Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Anions,Assays,Inhibitors,Peptides and proteins,Screening assays Get e-Alerts
<title>Use of the polarization vector in modeling tissue fluorescence: theoretical and experimental comparison</title> (1997)

This paper describes an innovative approach to tissue fluorescence as a phenomenon of inelastic scattering of electromagnetic radiation. A general formulation of the polarization vector of the medium is used in order to describe the fluorescence inelastic scattering process. The general method described, is applied to two different tissue models. In the first model, tissue is represented as a single infinitely thick, homogeneous layer, under plane wave excitation. The second model used is based on a picture of tissue as a single dielectric layer, under pulse excitation. In both cases, fluorophores and absorbing species are assumed to be homogeneously distributed inside tissue. The mathematical techniques used together with the fully evaluated theoretical results are presented. Additionally, experimental measurements were performed on collagen gels which contained various dyes in order to evaluate and validate our mathematical modeling.
SUBSENSITIVITY TO CHOLINOCEPTOR STIMULATION OF THE HUMAN IRIS SPHINCTER in situ FOLLOWING ACUTE AND CHRONIC ADMINISTRATION OF CHOLINOMIMETIC MIOTIC DRUGS (1980)

1 Maximal pupillary miosis was obtained with single topical applications of 4 cholinomimetic drugs in therapeutic concentrations to normal human subjects. 2 When the pupil had recovered from the miosis, there remained a reduced light reflex response of 22.7% at 24 h after aceclidine, 18.0% at 31 h after pilocarpine, 10.3% at 48 h after physostigmine and 4.9% at 7 h after arecoline. 3 This reduced sensitivity to light was accompanied by an overshoot of the resting pupil diameter and, after aceclidine miosis, a reduced response to a second application of miotic. 4 Similar findings were observed in glaucoma patients following withdrawal of chronic pilocarpine therapy. 5 It is suggested that the slowly reversible after-effects of acute and chronic administration of cholinomimetic miotics can be explained by desensitization of iris sphincter cholinoceptors.
Questioning Feminine Connection (1997)

This paper examines Nancy Chodorow's theory of feminine connection and masculine separation in The Reproduction of Mothering . First it demonstrates that, contrary to many feminists’ interpretations, Chodorow's theory does not portray masculine separation as a social problem to which feminine connection is the solution. Then it shows that Chodorow's apparently intended theory is incoherent. Finally, it argues that Chodorow's claims imply another theory that is coherent and that deserves feminists’ attention.
The Tristetraprolin Family of RNA-Binding Proteins in Cancer: Progress and Future Prospects (2020)

Post-transcriptional regulation of gene expression plays a key role in cellular proliferation, differentiation, migration, and apoptosis. Increasing evidence suggests dysregulated post-transcriptional gene expression as an important mechanism in the pathogenesis of cancer. The tristetraprolin family of RNA-binding proteins (RBPs), which include Zinc Finger Protein 36 (ZFP36; commonly referred to as tristetraprolin (TTP)), Zinc Finger Protein 36 like 1 (ZFP36L1), and Zinc Finger Protein 36 like 2 (ZFP36L2), play key roles in the post-transcriptional regulation of gene expression. Mechanistically, these proteins function by binding to the AU-rich elements within the 3'-untranslated regions of their target mRNAs and, in turn, increasing mRNA turnover. The TTP family RBPs are emerging as key regulators of multiple biological processes relevant to cancer and are aberrantly expressed in numerous human cancers. The TTP family RBPs have tumor-suppressive properties and are also associated with cancer prognosis, metastasis, and resistance to chemotherapy. Herein, we summarize the various hallmark molecular traits of cancers that are reported to be regulated by the TTP family RBPs. We emphasize the role of the TTP family RBPs in the regulation of trait-associated mRNA targets in relevant cancer types/cell lines. Finally, we highlight the potential of the TTP family RBPs as prognostic indicators and discuss the possibility of targeting these TTP family RBPs for therapeutic benefits.
Phosphatidylinositide 3-Kinase Is Important in Late-Stage Fibroblast Growth Factor-1-Mediated Angiogenesis in vivo (2005)

We previously reported that overexpression of a secreted version of fibroblast growth factor-1 (sp-FGF-1) has the ability to induce angiogenesis in the chicken chorioallantoic membrane (CAM). In our current study, we examine the effects of sp-FGF-1 through a time course analysis of angiogenesis in the chicken CAM on days 3, 4, and 5 after gene transfection. Significant angiogenesis was observed on days 4 and 5 after gene transfection in the CAM assay. To evaluate the role of phosphatidylinositide 3-kinase (PI3K) signaling in sp-FGF-1-induced angiogenesis, we analyzed mRNA expression levels of PI3K and protein activity through its immediate downstream target, AKT-1. We found upregulation of both PI3K and AKT mRNA expression levels in day 5 sp-FGF-1 versus day 5 vector control-transfected CAMs. Furthermore, by blocking PI3K phosphorylation using the specific inhibitor, LY294002, we found that downstream phosphorylation of AKT-1 was inhibited. More importantly, the blockade of the PI3K pathway via LY294002 in sp-FGF-1-transfected CAMs significantly inhibited angiogenesis. These results further elucidate the molecular mechanisms of the sp-FGF-1 signaling pathway and it underscores the importance of PI3K signaling in FGF-1-stimulated angiogenesis in vivo. It also provides a basis for the role of sp-FGF-1 in the development of therapeutic treatments to combat vascular insufficiencies and angiogenesis-dependent cancers.
Exercising With Peripheral or Autonomic Neuropathy: What Health Care Providers and Diabetic Patients Need to Know (2014)

Both peripheral and autonomic neuropathies are characterized by a progressive loss of nerve fiber function. Most peripheral neuropathy affects the extremities, particularly the lower legs and the feet, but also the hands, whereas damage to the autonomic nervous system may lead to imbalances between the sympathetic and parasympathetic nerve fibers that innervate the heart and blood vessels, as well as abnormalities in heart rate control and vascular dynamics. To prescribe or engage in exercise that is both safe and effective, health care providers and patients with diabetes mellitus need to increase their understanding of the pathophysiological nature of neuropathies and the physical activity hurdles that may arise from the presence of a neuropathy. With proper care and preventative measures, patients with diabetes mellitus that experience either type of neuropathy can benefit from regular participation in mild to moderate aerobic, resistance, and balance activities, assuming they take any potential alterations into account to ensure that exercise is safe and effective.
O-084 (2012)

Power, Melinda C.; Weisskopf, Marc G.; Alexeeff, Stacey E.; Wright, Robert O.; Coull, Brent A.; Spiro, Avron III; Schwartz, Joel Author Information
Equal Plasma Viral Loads Predict a Similar Rate of CD4+T Cell Decline in Human Immunodeficiency Virus (HIV) Type 1– and HIV‐2–Infected Individuals from Senegal, West Africa (2002)

Human immunodeficiency virus (HIV) type 2 infection is characterized by slower disease progression to acquired immunodeficiency syndrome than results from HIV-1 infection. To better understand the biological factors underlying the different natural histories of infection with these 2 retroviruses, we examined the relationship between HIV RNA and DNA levels and the rate of CD4(+) T cell decline among 472 HIV-1- and 114 HIV-2-infected individuals from Senegal. The annual rate of CD4(+) T cell decline in the HIV-2 cohort was approximately one-fourth that seen in the HIV-1 cohort. However, when the analysis was adjusted for baseline plasma HIV RNA level, the rates of CD4(+) T cell decline per year for the HIV-1 and HIV-2 cohorts were similar (a rate increase of approximately 4% per year for each increase in viral load of 1 log(10) copies/mL). Therefore, plasma HIV load is predictive of the rate of CD4(+) T cell decline over time, and the correlation between viral load and the rate of decline appears to be similar among all HIV-infected individuals, regardless of whether they harbor HIV-1 or HIV-2.
Therapeutic Vaccination with mRNA Transfected Dendritic Cells (2004)

s for the 19th Annual Scientific Meeting of the International Society for Biological Therapy of Cancer, San Francisco, California, November 4-7, 2004: Immune Adjuvants
Neutron Sources for Standard-Based Testing (2014)

The DHS TC Standards and the consensus ANSI Standards use 252Cf as the neutron source for performance testing because its energy spectrum is similar to the 235U and 239Pu fission sources used in nuclear weapons. An emission rate of 20,000 ± 20% neutrons per second is used for testing of the radiological requirements both in the ANSI standards and the TCS. Determination of the accurate neutron emission rate of the test source is important for maintaining consistency and agreement between testing results obtained at different testing facilities. Several characteristics in the manufacture and the decay of the source need to be understood and accounted for in order to make an accurate measurement of the performance of the neutron detection instrument. Additionally, neutron response characteristics of the particular instrument need to be known and taken into account as well as neutron scattering in the testing environment.