gebhart/patrepeval huggingface dataset:
Matrix Composition and Mechanics of Decellularized Lung Scaffolds (2011)

The utility of decellularized native tissues for tissue engineering has been widely demonstrated. Here, we examine the production of decellularized lung scaffolds from native rodent lung using two different techniques, principally defined by use of either the detergent 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate (CHAPS) or sodium dodecyl sulfate (SDS). All viable cellular material is removed, including at least 99% of DNA. Histochemical staining and mechanical testing indicate that collagen and elastin are retained in the decellularized matrices with CHAPS-based decellularization, while SDS-based decellularization leads to loss of collagen and decline in mechanical strength. Quantitative assays confirm that most collagen is retained with CHAPS treatment but that about 80% of collagen is lost with SDS treatment. In contrast, for both detergent methods, at least 60% of elastin content is lost along with about 95% of native proteoglycan content. Mechanical testing of the decellularized scaffolds indicates that they are mechanically similar to native lung using CHAPS decellularization, including retained tensile strength and elastic behavior, demonstrating the importance of collagen and elastin in lung mechanics. With SDS decellularization, the mechanical integrity of scaffolds is significantly diminished with some loss of elastic function as well. Finally, a simple theoretical model of peripheral lung matrix mechanics is consonant with our experimental findings. This work demonstrates the feasibility of producing a decellularized lung scaffold that can be used to study lung matrix biology and mechanics, independent of the effects of cellular components.
A Boosted Bayesian Multiresolution Classifier for Prostate Cancer Detection From Digitized Needle Biopsies (2010)

Diagnosis of prostate cancer (CaP) currently involves examining tissue samples for CaP presence and extent via a microscope, a time-consuming and subjective process. With the advent of digital pathology, computer-aided algorithms can now be applied to disease detection on digitized glass slides. The size of these digitized histology images (hundreds of millions of pixels) presents a formidable challenge for any computerized image analysis program. In this paper, we present a boosted Bayesian multiresolution (BBMR) system to identify regions of CaP on digital biopsy slides. Such a system would serve as an important preceding step to a Gleason grading algorithm, where the objective would be to score the invasiveness and severity of the disease. In the first step, our algorithm decomposes the whole-slide image into an image pyramid comprising multiple resolution levels. Regions identified as cancer via a Bayesian classifier at lower resolution levels are subsequently examined in greater detail at higher resolution levels, thereby allowing for rapid and efficient analysis of large images. At each resolution level, ten image features are chosen from a pool of over 900 first-order statistical, second-order co-occurrence, and Gabor filter features using an AdaBoost ensemble method. The BBMR scheme, operating on 100 images obtained from 58 patients, yielded: 1) areas under the receiver operating characteristic curve (AUC) of 0.84, 0.83, and 0.76, respectively, at the lowest, intermediate, and highest resolution levels and 2) an eightfold savings in terms of computational time compared to running the algorithm directly at full (highest) resolution. The BBMR model outperformed (in terms of AUC): 1) individual features (no ensemble) and 2) a random forest classifier ensemble obtained by bagging multiple decision tree classifiers. The apparent drop-off in AUC at higher image resolutions is due to lack of fine detail in the expert annotation of CaP and is not an artifact of the classifier. The implicit feature selection done via the AdaBoost component of the BBMR classifier reveals that different classes and types of image features become more relevant for discriminating between CaP and benign areas at different image resolutions.
EMA_ Testing: Hazard Analysis and Energy Storage Systems. (2015)

Abstract not provided.
[Aprotinin scintigraphy in amyloidosis]. (2009)

Amyloidosis is a disease characterized by protein deposition (amyloid) in THE extracellular matrix leading to organ dysfunction and death. New treatment modalities have emphasized the need for accurate and early diagnosis. Aprotinin scintigraphy is a radionuclide imaging technique in which the localisation and extent of amyloid deposits are visualized. It is specific and sensitive in detecting cardiac amyloidosis, which is associated with a poor prognosis. In addition, aprotinin scintigraphy appears to be a useful tool for the monitoring of disease progression and treatment efficacy.
THE IMPACT OF INCREASED CONSUMPTION OF FRUIT AND VEGETABLES ON POPULATION HEALTH AND FOOD BEHAVIOURS: THE CASE OF ALGERIA (2014)

ISHS III International Symposium on Human Health Effects of Fruits and Vegetables - FAVHEALTH 2009 THE IMPACT OF INCREASED CONSUMPTION OF FRUIT AND VEGETABLES ON POPULATION HEALTH AND FOOD BEHAVIOURS: THE CASE OF ALGERIA
Solution Structure of the Zbeta Domain of Human DAI and Its Binding Modes to B- and Z-DNAs (2011)

Korea (South). Ministry of Science and Technology (National Research Laboratory Program (NRL-2006-02287))
Dewatering of Diethylene Glycol and Lactic Acid Solvents by Membrane Distillation Technique (2018)

This chapter contains sections titled: Introduction Materials and Methods Results and Discussion Conclusions
Architecture of a multi-cell centralized packet access system (2002)

We present an architecture for a system with multi-cell centralized packet access. In micro- or pico-cellular environments, the coverage overlap by adjacent antenna units arises naturally, which means that a signal emitted by a mobile terminal is multiple received. The whole service area of the system is parceled out into small coverage zones, to which channels are dynamically allocated. For such a dynamic channel allocation to be effective, the system has to attach the mobile terminals to the zones of allocation, based on the strength of the received signal. We study the problem of this fine-localization of the mobile terminals in the presence of fast fading.
REISOLATION AND EMENDATION OF DESCRIPTION OFVIBRIO MARINUS(RUSSELL) FORD (1964)

Colwell, Rita R. (Georgetown University, Washington, D.C.), and Richard Y. Morita. Reisolation and emendation of description of Vibrio marinus (Russell) Ford. J. Bacteriol. 88:831-837. 1964.-Sixteen fresh isolates from the marine environment were subjected to taxonomic analysis. From the taxonomic data, both quantitative and qualitative, these strains appear to form a species-group closely related to the Vibrio marinus isolated by Russell from the gulf of Naples in 1891. The V. marinus species description is extended. As a peculiarly marine species, the organisms are distinguished by features of inorganic salt requirement and psychrophilism, as well as by an ability to form acid from glucose anaerobically and a marked curvature of the cells.
Can Peer-to-Peer live streaming systems coexist with free riders? (2013)

Peer-to-Peer live streaming systems help content providers and distributors drastically reduce bandwidth costs by sharing costs among peers. Researchers have dedicated significant effort developing techniques to discourage or exclude uncooperative peers from peer-to-peer systems. However, users are often unable to cooperate, e.g., users using a mobile device with limited, costly bandwidth. We study the impact of uncooperative peers on video discontinuity and latency using PlanetLab. We find that simple mechanisms, like forwarding video data requests to cooperative peers instead of wasting effort sending requests to uncooperative peers, allows peer-to-peer live streaming to serve 50% of uncooperative peers without performance degradation. We argue that denying service to uncooperative peers may not be the best long-term approach; our findings suggest that peer-to-peer live streaming can support uncooperative peers.
Comparative Transcriptome Analysis of Cell-Free Fetal RNA from Amniotic Fluid and RNA from Amniocytes in Uncomplicated Pregnancies (2015)

This study demonstrated differential tissue-specific gene expression profiles and biological pathways between AFS and amniocytes. The results suggested that AFS is the preferred RNA source to investigate potential biomarkers of fetal neurodevelopment.
Analysis of the Lau effect and generalized grating imaging (1985)

The images formed under incoherent illumination by two gratings in tandem are analyzed using the theory of grating imaging. The images are categorized on the basis of various integer parameters that arise in the analysis. A transfer function is introduced for describing the imaging process. The image positions are related to the foci of a Fresnel zone plate.
HEREDITARY PHEOCHROMOCYTOMA ASSOCIATED WITH SDHB GENE GERMLINE MUTATION (2004)

Peczkowska, M.; Buchta, M.; Me Whinney, S. R.; Janaszek-Sitkowska, H.; Kabat, M.; Januszewicz, M.; Prejbisz, A.; Eng, C.; Neumann, H. P.H.; Januszewicz, A. Author Information
Visceral Fat and Novel Biomarkers of Cardiovascular Disease in Patients With Addison’s Disease: A Case-Control Study (2017)

Despite higher cortisol exposure, VAT was not increased in patients with AD. The prevalence of MetS was increased and several biomarkers of cardiovascular disease were adversely affected in patients with AD.
Outbreak of Enteritis Due to Duck Eggs (1949)

On the morning of July 7, 1949, about 40 nurses at St. Bartholomew's Hospital had reported sick with an acute febrile enteritis, and many patients throughout the wards of the hospital were similarly affected. Inquiry in the kitchen revealed that a lightly cooked pudding containing 200 duck eggs had been served to the nursing and other female staff and to patients on July 5. It was therefore no surprise when stool cultures revealed the presence of Salmonella typhi-murium. The outbreak was on an exceptional scale for one so produced, and had features which appear worthy of record. Source of Infection
New iterative flux based in the design strategy for freeform surfaces generation for LED lighting technology (2011)

We present a new strategy to calculate an optimized refractive freeform surface for illumination purposes with a LED source. The goal of this paper is to present a new iterative flux based strategy to design plastic lens for LED lighting solutions. The new strategy considers the energy emission pattern of the LED and adjusts a plastic refractive surface to accomplish the target intensity distribution. This paper is divided in four parts, a brief introduction to LED systems and reviewing optical design strategies, the method of calculus is exposed in the second part, third part presents the results for a particular refractive optical design developed by new presented algorithm and finally, a set of conclusions about strategy is showed in fourth part.
New JCS Editor (2002)

We are delighted to announce the appointment of Kathleen Green as an Editor of Journal of Cell Science. Currently Joseph L. Mayberry Professor of Pathology and Toxicology at Northwestern University Medical School, Kathy is a leading figure in the field of cell adhesion. Her research career started at Washington University in St Louis, where she obtained a PhD in Cell and Developmental Biology in 1982. Kathy then moved to the Department of Cell Biology at Northwestern to pursue post-doctoral research on intermediate filaments. She subsequently joined the Departments of Pathology and Dermatology, where for several years a major focus of her research has been the structure and functions of desmosomes. Indeed, her work has been instrumental in illuminating the biology of plakins, a family of modular proteins that link cytoskeletal networks with adhesive junctions such as desmosomes and hemidesmosomes.Kathy has been a regular contributor to and reviewer for JCS for many years and joined the Editorial Board of the journal in 1992. On behalf of all the Editors and staff at JCS, we welcome Kathy to the editorial team and look forward to working with her.
Craniotomy: True Sham for Traumatic Brain Injury, or a Sham of a Sham? (2010)

Abstract Neurological dysfunction after traumatic brain injury (TBI) is caused by both the primary injury and a secondary cascade of biochemical and metabolic events. Since TBI can be caused by a variety of mechanisms, numerous models have been developed to facilitate its study. The most prevalent models are controlled cortical impact and fluid percussion injury. Both typically use "sham" (craniotomy alone) animals as controls. However, the sham operation is objectively damaging, and we hypothesized that the craniotomy itself may cause a unique brain injury distinct from the impact injury. To test this hypothesis, 38 adult female rats were assigned to one of three groups: control (anesthesia only); craniotomy performed by manual trephine; or craniotomy performed by electric dental drill. The rats were then subjected to behavioral testing, imaging analysis, and quantification of cortical concentrations of cytokines. Both craniotomy methods generate visible MRI lesions that persist for 14 days. The initial lesion generated by the drill technique is significantly larger than that generated by the trephine. Behavioral data mirrored lesion volume. For example, drill rats have significantly impaired sensory and motor responses compared to trephine or naïve rats. Finally, of the seven tested cytokines, KC-GRO and IFN-γ showed significant increases in both craniotomy models compared to naïve rats. We conclude that the traditional sham operation as a control confers profound proinflammatory, morphological, and behavioral damage, which confounds interpretation of conventional experimental brain injury models. Any experimental design incorporating "sham" procedures should distinguish among sham, experimentally injured, and healthy/naïve animals, to help reduce confounding factors.
ChemInform Abstract: Salfredins, New Aldose Reductase Inhibitors Produced by Crucibulum sp. RF‐3817. Part 1. Fermentation, Isolation and Structures of Salfredins. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Repositioning doxycycline for treating Parkinson’s disease: Evidence from a pre‐clinical mouse model (2021)

Background Parkinson’s disease (PD) is a neurodegenerative disorder orphan of valuable therapies. PD is neuropathological characterized by intracellular Lewy bodies formed by aggregated α-synuclein (α-syn ) in mesencephalic region and neuroinflammation significantly contribute to the pathogenesis of the disease. In the complex scenario of PD single target therapy cannot be beneficial, a therapeutic strategy simultaneously affecting α-syn aggregation and neuroinflammation may be useful to affect PD progression. Recently, the antimicrobial drug Doxycycline (Doxy) has been demonstrated to inhibit α-syn aggregation. In addition, we have reported that Doxy at sub-antibiotic doses efficiently counteracts memory impairment and neuroinflammation in a transgenic (Tg) mouse model of Alzheimer’s Disease. Based on the multiple action mechanism of Doxy, we herein investigate the potential therapeutic properties of Doxy in a Tg PD mouse model. Method A53T mice and their non-Tg (NTG) litter mates were intraperitoneally treated with 10mg/Kg Doxy for 30 days. At the end of treatment, cognitive and motor performances were evaluated in the Novel object recognition test (NORT), Nesting test, Beam-walk and Paw grip endurance. In addition, hippocampal long term potentiation (LTP) was assessed. Neuropathological markers were explored through immunohistological and biochemical approaches. Result Doxy abolished the cognitive deficit in the NORT. Moreover, Doxy restored daily life activity of A53T mice in the Nesting test, which is dependent by hippocampal and cortical networks. Aside from an effect at cognitive level, we found that Doxy treatment ameliorated motor performances in both the Beam-walk test and in the Paw grip endurance. The effect on cognitive functions was strictly linked to a reduced neuronal loss in the cortex and hippocampus of A53T+Doxy compared to A53T+Veh group. Moreover, glial activation were blocked by our pharmacological approach both in the cortex and hippocampus. In addition, Doxy treatment restored hippocampal LTP in association with the dampening of pro-inflammatory cytokines expression. Conclusion Doxy emerges as a valuable therapeutic approach to counteract both symptoms and neuropathological hallmarks in the complex scenario of a Tg PD mouse model. Moreover, our results depict PD as a novel field for repurposing Doxy and corroborate previous data indicating Doxy as a multi-target drug.
A Short Comparison of Damping Functions of Standard Low-Reynolds-Number k-ε Models (1997)

Technical Briefs A Short Comparison of Damping Functions of Standard Low-Reynolds-Number k-ε Models A. N. Rousseau, A. N. Rousseau Institut National de la Recherche Scientifique (INRS)-Eau 2800 rue Einstein, Suite 105, C. P. 7500, Ste-Foy, P. Q. Canada GIV 4C7 Search for other works by this author on: This Site PubMed Google Scholar L. D. Albright, L. D. Albright Department of Agricultural and Biological Engineering, Cornell University, Ithaca, NY 14853-5701 Search for other works by this author on: This Site PubMed Google Scholar K. E. Torrance K. E. Torrance Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY 14853-5701 Search for other works by this author on: This Site PubMed Google Scholar Author and Article Information A. N. Rousseau Institut National de la Recherche Scientifique (INRS)-Eau 2800 rue Einstein, Suite 105, C. P. 7500, Ste-Foy, P. Q. Canada GIV 4C7 L. D. Albright Department of Agricultural and Biological Engineering, Cornell University, Ithaca, NY 14853-5701 K. E. Torrance Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY 14853-5701 J. Fluids Eng. Jun 1997, 119(2): 460-463 (4 pages) https://doi.org/10.1115/1.2819158 Published Online: June 1, 1997 Article history Received: January 24, 1996 Revised: January 8, 1997 Online: December 4, 2007
SETX sumoylation (2014)

Senataxin (SETX) is a putative RNA:DNA helicase that is mutated in two distinct juvenile neurological disorders, AOA2 and ALS4. SETX is involved in the response to oxidative stress and is suggested to resolve R loops formed at transcription termination sites or at sites of collisions between the transcription and replication machineries. R loops are hybrids between RNA and DNA that are believed to lead to DNA damage and genomic instability. We discovered that Rrp45, a core component of the exosome, is a SETX-interacting protein and that the interaction depends on modification of SETX by sumoylation. Importantly, we showed that AOA2 but not ALS4 mutations prevented both SETX sumoylation and the Rrp45 interaction. We also found that upon replication stress induction, SETX and Rrp45 co-localize in nuclear foci that constitute sites of R-loop formation generated by transcription and replication machinery collisions. We suggest that SETX links transcription, DNA damage and RNA surveillance, and discuss here how this link can be relevant to AOA2 disease.
Cardiac differentiation of human pluripotent stem cells using defined extracellular matrix proteins reveals essential role of fibronectin (2022)

Research and therapeutic applications using human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) require robust differentiation strategies. Efforts to improve hPSC-CM differentiation have largely overlooked the role of extracellular matrix (ECM). The present study investigates the ability of defined ECM proteins to promote hPSC cardiac differentiation. Fibronectin (FN), laminin-111, and laminin-521 enabled hPSCs to attach and expand. However, only addition of FN promoted cardiac differentiation in response to growth factors Activin A, BMP4, and bFGF in contrast to the inhibition produced by laminin-111 or laminin-521. hPSCs in culture produced endogenous FN which accumulated in the ECM to a critical level necessary for effective cardiac differentiation. Inducible shRNA knockdown of FN prevented Brachyury<sup>+</sup> mesoderm formation and subsequent hPSC-CM generation. Antibodies blocking FN binding integrins α4β1 or αVβ1, but not α5β1, inhibited cardiac differentiation. Furthermore, inhibition of integrin-linked kinase led to a decrease in phosphorylated AKT, which was associated with increased apoptosis and inhibition of cardiac differentiation. These results provide new insights into defined matrices for culture of hPSCs that enable production of FN-enriched ECM which is essential for mesoderm formation and efficient cardiac differentiation.
Improved dispersion of clay platelets in poly(butylene terephthalate) nanocomposite by ring‐opening polymerization of cyclic oligomers: Effect of the processing conditions and comparison with nanocomposites obtained by melt intercalation (2009)

Abstract Poly(butylene terephthalate) nanocomposites with organically modified montmorillonites have been prepared by in‐situ ring opening polymerization of PBT cyclic oligomers. High molecular weight polymers can be obtained by choosing the proper polymerization conditions and catalyst in very short polymerization time (10 min) and low temperature (205°C). A better dispersion of the clay and a consistently higher M w have been obtained by this method respect to the standard melt intercalation approach, leading to improved thermo‐mechanical properties of the nanocomposite. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009
Alcohol fermentation of corn starch digested by Chalara paradoxa amylase without cooking (1987)

Alcohol fermentation of corn starch without cooking was performed by using Chalara paradoxa glucoamylase preparation, which had stronger raw starch digesting activity than those of the conventionally known glucoamylases. A raw corn starch-enzyme-yeast mixture was fermented optimally at pH 5.0 and 30 degrees C for five days and produced ethanol. The yields of ethanol were between 63.5 and 86.8% of the theoretical value by baker's yeast (Saccharomyces cerevisiae), and between 81.1 and 92.1% of the theoretical value by sake yeast (Saccharomyces sake).
NOVEL POLYPHENYLENES CONTAINING ORTHOGONAL PHENYL AND BENZO-CROWN-ETHER GROUPS (2001)

The synthesis of a new class of polyphenylenes substituted with a large number of phenyl and benzo-crown-ether groups has been described. The polymers, prepared by Suzuki cross-coupling reaction between polyphenylated dibromide and benzene-1,4-diboronic acid, exhibit outstanding solubility in common organic solvents such as THF and chloroform. Preliminary results on molecular weights and thermal analysis of one representative polymer are discussed.