gebhart/patrepeval huggingface dataset:
Reducing access energy of on-chip data memory considering active data bitwidth (2002)

This paper presents a new concept called active data bitwidth, which is the effective data length of data bus. By means of profiling the active data bitwidth dynamically, we present a novel low-energy memory access technique for on-chip data memory design. By reducing the redundant access energy of data memory, our experimental results of two real applications, show that we can achieve significant energy reduction. Compared to the monolithic memory, for JPEG, 52.2%; for MPEG-2 84.2%, the energy reduction is reported. Compared to the memory banking technique, 12.3% energy reduction for JPEG and 65.9% for MPEG-2 is reported.
Divalent Metal Incorporation in MIL‐74, the Super‐Sodalite Aluminum Phosphates M3Al6 (PO4)12×4tren×17H2O (M: Mg, Mn, Co) and Its Gallium Phosphate Analogues M′3Ga6 (PO4)12×4tren×17H2O (M′: Mg, Mn, Co, Fe, Zn). (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Low-Voltage STEM-Eels Quantification for Lithium Ion Battery Material Characterization (2020)

In material sciences, in order to develop new compounds with different electrical, mechanical or optical properties we need to understand the link between these properties and the microstructure of the material. This apply also to understand the decrease of efficiency of a battery after multiple charge-discharge cycle where the structural changes need to be identify in order to prevent it. Scanning transmission electron microscopy (STEM) has been proven to be a powerful tool for the study of microstructure and morphology with a subnanometer resolution. Furthermore, a STEM paired with electron energy loss spectroscopy (EELS) can provide useful information on the specimen elemental composition. However, these technique are normally used with a high electron beam voltage (80-200 keV) and the high energy of the electron beam induce beam damage into low Z materials such as lithium compound. This becomes problematic when the microstructure of a LIB is observed since the change into the material cause by the beam damage is close to the changes cause by the use of batteries during cycling. To prevent beam damage such as knock-on damage, the electron beam voltage need to be reduce to relatively low kV. However, no work on low voltage EELS quantification has been reported. This study will present the acquisition of EELS spectrum using a state-of-the-art dedicated transmission scanning electron microscope (Hitachi-SU9000EA) at 30 keV. Low-voltage EELS quantification on standard will be presented using the integration ratio method. Interesting results will be presented on the inelastic cross-section measurement at low-voltage with the combination of convergent beam electron diffraction(CBED) and EELS. Theses values will be compared with the cross-section obtain using computational calculation that are normally used for high voltage EELS quantification.
Novel Compact High-Pass Filter with Sharp Attenuation Slope Using Cross-Coupling in the Multi-Layer Structure (2012)

A planar high-pass filter (HPF) by using cross-couplings in multi-layer structure is proposed in this paper. The HPF consists of parallel plate and gap type capacitors and inductor lines on the bottom conductor. The one block of the HPF has a ladder T-section in the bridge T configuration. The one block HPF is, thus, coarsely designed in the manner of the proto-type HPF and the performance is optimized by circuit simulator. With the gap capacitor adjusted the proposed HPF illustrates the steep slope characteristics near the cut-off frequency by the attenuation pole. In order to improve the stopband performance, the cascaded two block HPF is examined. Its measured results show the good agreement with the simulated ones giving the second attenuation pole by an inductive cross-coupling.
87 Comparison of functional ability in siblings with duchenne muscular dystrophy (2020)

<h3></h3> Early diagnosis is important to optimise management and prolong function in patients with Duchenne Muscular Dystrophy (DMD). There is little research comparing functional outcomes of siblings diagnosed at different ages. This study aims to analyse the effect of age at diagnosis and prescription of steroids on function in siblings with the same genetic diagnosis of DMD. Functional ability was measured using the North Star Ambulatory Assessment (NSAA) which is a validated outcome measure in ambulant children with DMD. NSAA data from 24 siblings (48 patients) was collected from their first NSAA assessment at Great Ormond Street Hospital, including all scores until July 2020. Age matched NSAA scores were collated at 6 monthly intervals (± 3 months) between 5.5–10.5 years in siblings, where one or more NSAA scores could be compared. 17 siblings (34 patients) met the inclusion criteria and were analysed. Results show that younger siblings were diagnosed on average 2.7 years earlier and started steroids 0.8 years earlier. The median peak NSAA scores were higher in older siblings at ages 5.26–6.25 and 7.26–8.25 years. Between 6.26–7.25 and after 8.26 years, the younger siblings median NSAA scores were consistently higher, although there were small numbers in each sub-group. Wilcoxon Signed Rank test showed no significant differences between groups. Analysis of the graph suggests that despite the earlier age at diagnosis, younger siblings did not diverge from the older sibling in the first phase of the disease. Visual inspection of the NSAA score shows that after 8 years old, the younger siblings consistently scored higher values. This suggests that earlier initiation of steroids is likely to have played a role in this outcome, as previously demonstrated in the DMD population. Further research will assess long-term effects of these trends, regarding age at loss of ambulation, and of respiratory insufficiency.
Abstract 3669: Chemoprevention of mammary and prostate cancer by phenethyl isothiocyanate in vivo is associated with suppression of vimentin protein expression. (2013)

Abstract Phenethyl isothiocyanate (PEITC), a constituent of many edible cruciferous vegetables (eg, watercress), exhibits in vivo preventive efficacy against cancer in rodents induced by structurally diverse chemical carcinogens. We have also shown recently that dietary administration of PEITC (3 μmol PEITC/g diet) confers significant protection against breast and prostate cancer development in MMTV-neu and TRAMP model, respectively. Prevention of prostate cancer by PEITC administration in TRAMP mice was associated with induction of E-cadherin protein expression. Because suppression of E-cadherin protein level concomitant with induction of mesenchymal markers (eg, vimentin) is a biochemical hallmark of epithelial-mesenchymal transition, a process implicated in cancer metastasis, we hypothesized that PEITC treatment was likely to suppress vimentin protein expression. Contrary to this prediction, exposure of cultured human breast (MDA-MB-231) and prostate cancer cells (PC-3 and DU145) to PEITC resulted in a dose-dependent increase in vimentin protein level, which was observed as early as 6 hours post-treatment and persisted for the duration of the experiment (24 hours). RNA interference of vimentin resulted in a modest augmentation of PEITC-mediated inhibition of MDA-MB-231 and PC-3 cell migration as well as cell viability. Furthermore, the PEITC-induced apoptosis was moderately increased upon siRNA knockdown of vimentin protein level in MDA-MB-231 and PC-3 cells. To our surprise, PEITC administration caused a marked decrease in vimentin protein expression in vivo in tumors of MMTV-neu (breast) and TRAMP mice (prostate). The results of the present study indicate that cancer chemoprevention by PEITC in vivo is associated with suppression of vimentin protein expression. The present study was supported by the grant CA101753-09 awarded by the National Cancer Institute. Citation Format: Kozue Sakao, Eun-Ryeong Hahm, Shivendra V. Singh. Chemoprevention of mammary and prostate cancer by phenethyl isothiocyanate in vivo is associated with suppression of vimentin protein expression. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3669. doi:10.1158/1538-7445.AM2013-3669
Ultrafast lattice dynamics in FeRh during a laser-induced magnetic phase transition (2010)

Time-resolved X-ray diffraction is used to study the lattice response of FeRh during a laser-driven anti-ferromagnetic to ferromagnetic phase transition. The experiments reveal a fast and a slow component in the induced expansion dynamics.
Comparative genomics of methicillin-resistant Staphylococcus aureus ST239: distinct geographical variants in Beijing and Hong Kong (2014)

Comparative genomics, based on de novo assembly and deep sequencing of HK and BJ strains, revealed different origins of the ST239 lineage in northern and southern China and identified differences between the two clades at single nucleotide polymorphism (SNP), core gene and MGE levels. The results suggest that ST239 strains isolated in Hong Kong since the 1990s belong to the Asian clade, present mainly in southern Asia, whereas those that emerged in northern China were of a distinct origin, reflecting the complexity of dissemination and the dynamic evolution of this ST239 lineage.
Serine- and threonine-rich domain regulates internalization of muscarinic cholinergic receptors. (1993)

Upon agonist exposure, most membrane receptors internalize into the cell as part of an adaptation process. Receptor domains that mediate internalization have been defined for several receptor classes, e.g. growth factor and transport receptors, but not yet for any of the numerous members of the family of G protein-coupled receptors (GPCRs), having seven putative transmembrane helices. With the use of deletion mutations, we previously showed that a small region in the middle of the third intracellular loop (i3) appears to be required for the agonist-induced internalization of the Hm1 muscarinic cholinergic receptor (Lameh, J., Philip, M., Sharma, Y. K., Moro, O., Ramachandran, J., and Sadée, W. (1992) J. Biol. Chem. 267, 13406-13412). Using point mutations, we now demonstrate that domain 286-292 (ESLTSSE) is required, with TSS playing a crucial role. Although the i3 loops of GPCRs share minimal overall sequence identity, even among closely related subtypes, small domains containing multiple S/T residues are also present in several other GPCRs, e.g. peptide, catechol, and all the muscarinic cholinergic receptor subtypes. S/T-->A mutations in analogous i3 domains also prevented receptor internalization in the case of Hm3 and attenuated internalization of Hm2. We propose that an S/T-rich domain in the i3 loop, possibly via phosphorylation reactions, regulates one pathway of GPCR internalization.
Irradiance Monitoring Network Data (2015)

The data.tar.gz archive contains data from an irradiance monitoring network in Tucson, Arizona for the period 2014-04-05 to 2014-06-30. It includes a sensor metadata csv, csv files for the measurements on each day, and csv files for the clearsky-profiles for each sensor on each day. This data was used to make short-term forecasts of solar irradiance.
Comparative Effectiveness of Nutritional and Biological Therapy in North American Children with Active Crohnʼs Disease (2015)

Although PEN improved clinical symptoms, EEN and anti-TNF were more effective for decreasing mucosal inflammation and improving specific aspects of QOL.
Supplementary Figure from Ewing Sarcoma and Osteosarcoma Have Distinct Immune Signatures and Intercellular Communication Networks (2023)

Supplementary Figure from Ewing Sarcoma and Osteosarcoma Have Distinct Immune Signatures and Intercellular Communication Networks
Redosing Adeno-Associated Virus Gene Therapy to the Central Nervous System (2022)

Adeno-associated virus (AAV)-mediated gene therapies have provided promising treatments for numerous neurological disorders. Redosing of AAV to the central nervous system (CNS) is an attractive research area due to both the somewhat immunologically privileged status of the CNS as well as the possibility of reduced glial transgene expression over time following a single injection. Continued study of the immune responses to both intraparenchymal and intra-CSF delivery of AAV mediated gene therapies, as well as the continued study of immunosuppressive regimens, could allow for eventual redosing in patients.
Physical activity and health: Findings from Finnish monozygotic twin pairs discordant for physical activity (2022)

Genetic and early environmental differences including early health habits associate with future health. To provide insight on the causal nature of these associations, monozygotic (MZ) twin pairs discordant for health habits provide an interesting natural experiment. Twin pairs discordant for leisure-time physical activity (LTPA) in early adult life is thus a powerful study design to investigate the associations between long-term LTPA and indicators of health and wellbeing. We have identified 17 LTPA discordant twin pairs from two Finnish twin cohorts and summarize key findings of these studies in this paper. The carefully characterized rare long-term LTPA discordant MZ twin pairs have participated in multi-dimensional clinical examinations. Key findings highlight that compared with less active twins in such MZ twin pairs, the twins with higher long-term LTPA have higher physical fitness, reduced body fat, reduced visceral fat, reduced liver fat, increased lumen diameters of conduit arteries to the lower limbs, increased bone mineral density in loaded bone areas, and an increased number of large high-density lipoprotein particles. The findings increase our understanding on the possible site-specific and system-level effects of long-term LTPA.
Diagnosis and Management of Radiation Necrosis in Patients With Brain Metastases (2018)

The use of radiotherapy, either in the form of stereotactic radiosurgery (SRS) or whole-brain radiotherapy (WBRT), remains the cornerstone for the treatment of brain metastases (BM). As the survival of patients with BM is being prolonged, due to improved systemic therapy (i.e., for better extra-cranial control) and increased use of SRS (i.e., for improved intra-cranial control), patients are clinically manifesting late effects of radiotherapy. One of these late effects is radiation necrosis (RN). Unfortunately, symptomatic RN is notoriously hard to diagnose and manage. The features of RN overlap considerably with tumor recurrence, and misdiagnosing RN as tumor recurrence may lead to deleterious treatment which may cause detrimental effects to the patient. In this review, we will explore the pathophysiology of RN, risk factors for its development, and the strategies to evaluate and manage RN.
Wavelet-based munifractal formalism to assist in diagnosis in digitized mammograms (2001)

International audience
Sub-25nm FinFET with advanced fin formation and short channel effect engineering (2011)

FinFET devices achieving N/P Ion values of 1250/950 uA/um at 100nA/um at 1V, 1300/1000 uA/um with self-heating correction, are demonstrated, using a dual work function gate-first process flow at 100 nm gate pitch and 40 nm fin pitch. Ring-oscillator (RO, FO=3) functionality has been demonstrated, showing excellent Vdd scalability. We have also demonstrated logic scan chain functionality and yield improvement by optimizing the gate stack process. An optimized SIT process has been developed to improve short-channel characteristics in devices with a small number of fins in a narrow active area, which is also critical for manufacturability improvement. Various conformal doping techniques for NFET/PFET are optimized to improve device performance.
Robotic manipulators with double encoders: accuracy improvement based on advanced stiffness modeling and intelligent control (2018)

International audience
The spectrum of pressor-response to norepinephrine in normotensive and hypertensive patients. (1976)

The pressor-response to norepinephrine was determined in the whole body circulation of 15 normal subjects and 86 untreated essential hypertensive patients. The slope, the threshold-dose and the critical-dose were calculated from the log dose-response curve. In the overall population (101 subjects) a slight correlation (r = +0.20 less than 0.05) was observed between the basal diastolic arterial pressure and the threshold-dose. In contrast, highly significant parabolic correlations (r = +0.46 less than 0.00001) were observed between the diastolic arterial pressure and the slope or the critical dose. When diastolic arterial pressure was above 100 mmHg, the slope increased while the blood pressure increased. This result suggests either a decreased sympathetic tone or an adaptative structural change of the arterial wall. When diastolic arterial pressure was under 100 mmHg, the slope decreased while the blood pressure increased. This observation points to an enhanced sympathetic activity in mild blood pressure.
Collisional Damping of Plasma Oscillations (1969)

The attenuation of longitudinal electron oscillations in a dilute plasma is evaluated from the Krook approximation to the Boltzmann equation. The predictions of this model are compared with those of various other collision models. In the limit of "few collisions" there is complete qualitative agreement. However, the quantitative agreement among contributions beyond those due to dynamical friction is poor.
Overview of Machine Learning and Deep Learning Concepts (2020)

In this chapter, we focus on exploring the realms of machine learning and deep learning algorithms. Datasets from the previous chapter are used in this chapter as well. In addition, we introduce some new public datasets to build machine learning and deep learning models. In the previous chapter, you learned the basic concepts of Python programming. In this chapter, we start using Python programming and related libraries to explore the data and doing data wrangling to clean it so that it can be used as an input for different machine learning models. The chapter is divided into seven broad sections, starting with the overview of machine learning.
[FSH is a limiting factor]. (2005)

FSH concentrations obtained early in the follicular phase is a good predictive factor of ovarian response for assisted reproductive treatment. Nevertheless, FSH levels should be correlated with estradiol levels, antral follicle count and patient age. A history of elevated basal FSH levels in patients under the age of 40 years predicts a lower oocyte yield in IVF cycles but does not translate to either lower pregnancy or implantation rates. In women with uncertain ovarian function, antral follicle count and serum antimullerian hormone/mullerian-inhibiting substance appear to be more discriminatory markers of assisted reproductive technology outcome.
Learning the Predictability of the Future (2021)

We introduce a framework for learning from unlabeled video what is predictable in the future. Instead of committing up front to features to predict, our approach learns from data which features are predictable. Based on the observation that hyperbolic geometry naturally and compactly encodes hierarchical structure, we propose a predictive model in hyperbolic space. When the model is most confident, it will predict at a concrete level of the hierarchy, but when the model is not confident, it learns to automatically select a higher level of abstraction. Experiments on two established datasets show the key role of hierarchical representations for action prediction. Although our representation is trained with unlabeled video, visualizations show that action hierarchies emerge in the representation.
Proportion of cells with paternal 11p15 uniparental disomy correlates with organ enlargement in Wiedemann-Beckwith syndrome (2000)

“Genetic mosaicism” describes the presence of two or more populations of cells within a single individual that differ in their genomic constitution. Although the occurrence of asymmetric overgrowth in Wiedemann-Beckwith syndrome (WBS) suggests that mosaicism has some role in the WBS phenotype, no direct evidence for this has been published. WBS is a congenital overgrowth syndrome with variable phenotype linked to the imprinted gene cluster on chromosome region 11p15. We have performed a molecular survey of multiple organs and tissues in a case of WBS with a high degree of mosaic paternal 11p15 uniparental disomy (UPD). The organs most severely affected were those with the highest percentage of cells with UPD. In particular there was a striking difference in the degree of mosaicism for 11p15 UPD between the extremely enlarged left adrenal and non-enlarged right adrenal gland. This result indicates that the proportion of paternal 11p15 UPD cells correlates with the tissue phenotype of WBS. Our results suggest that high proportions of abnormal cells result from a combination of stochastic events and cell selection. Mosaicism may explain the variable phenotypes including hemihyperplasia and predisposition to childhood cancers in WBS patients. Am. J. Med. Genet. 92:111–116, 2000. © 2000 Wiley-Liss, Inc.
Data from Immunotherapeutic Targeting and PET Imaging of DLL3 in Small-Cell Neuroendocrine Prostate Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;Effective treatments for &lt;i&gt;de novo&lt;/i&gt; and treatment-emergent small-cell/neuroendocrine (t-SCNC) prostate cancer represent an unmet need for this disease. Using metastatic biopsies from patients with advanced cancer, we demonstrate that delta-like ligand 3 (DLL3) is expressed in &lt;i&gt;de novo&lt;/i&gt; and t-SCNC and is associated with reduced survival. We develop a PET agent, [&lt;sup&gt;89&lt;/sup&gt;Zr]-DFO-DLL3-scFv, that detects DLL3 levels in mouse SCNC models. In multiple patient-derived xenograft models, AMG 757 (tarlatamab), a half-life–extended bispecific T-cell engager (BiTE) immunotherapy that redirects CD3-positive T cells to kill DLL3-expressing cells, exhibited potent and durable antitumor activity. Late relapsing tumors after AMG 757 treatment exhibited lower DLL3 levels, suggesting antigen loss as a resistance mechanism, particularly in tumors with heterogeneous DLL3 expression. These findings have been translated into an ongoing clinical trial of AMG 757 in &lt;i&gt;de novo&lt;/i&gt; and t-SCNC, with a confirmed objective partial response in a patient with histologically confirmed SCNC. Overall, these results identify DLL3 as a therapeutic target in SCNC and demonstrate that DLL3-targeted BiTE immunotherapy has significant antitumor activity in this aggressive prostate cancer subtype.&lt;/p&gt;Significance:&lt;p&gt;The preclinical and clinical evaluation of DLL3-directed immunotherapy, AMG 757, and development of a PET radiotracer for noninvasive DLL3 detection demonstrate the potential of targeting DLL3 in SCNC prostate cancer.&lt;/p&gt;&lt;/div&gt;