gebhart/patrepeval huggingface dataset:
Wireless sensor networks for area monitoring and integrated vehicle health management applications (1999)

components on a single die that will be produced in high volumes for low-cost. This will permit large numbers of Distributed, wireless, microsensor networks promise to wireless integrated networked sensors to be easily and enable a myriad of applications for sensing and controlling rapidly deployed. (e.g., airdropped into battlefields or the physical world. Rockwell Science Center has created a deployed throughout an aircraft or space vehicle) to form development environment for wireless integrated networked highly redundant, self-configuring, ad hoc sensor networks. sensors (WINS) that includes customizable, sensor-laden For ease of deployment, the nodes use wireless networked nodes and both mobile and inter-net-hosted user communications and are capable of establishing and interfaces. The development system allows operating their own network. To prolong battery life, all node and network. functions are designed to consume examination of issues relative to design, deployment and usage of microsensor networks. nodes sense their minimal power. Highly capable and ultra-reliable systems environment via multiple sensors, process sensor data both will be built out of large numbers of such nodes that are autonomously and in cooperation with neighboring nodes individually inexpensive and use cooperation between nodes into information, and communicate this information to users to produce highly reliable, high quality information. A via a variety of network topologies. are self- summary of the technologies comprising the systems ~organizing in that they establish and maintain the network is shown in Fig. 1. Rockwell's experience with prototype without user intervention. Minimizing power consumption wireless sensor networks points to the great ~potential for is a primary driver in development. Each node robust, large-scale environmental and systems monitoring processes sensor data into information, thereby reducing and control. power-hungry communications requirements. Power minimization also drives the design of integrated The Rockwell Science Center, in collaboration with hardware and the creation of new networking protocols researchers at UCLA, has developed a prototype specific to the needs of microsensor networks. Prototype development platform for experimenting with microsensor are being applied to area monitoring, surveillance, networks under a number of government and industry and physical security, to networking of personnel and sponsored programs. The prototype node, called WINS l, physical assets over large areas, as well as to machinery and is based on an open, modular design using widely available platform health and status monitoring. The commercial-off-the-shelf (COTS) technology. To date more development environment and several of these applications than one hundred units of the latest version of wireless are discussed here.
Towards Squalamine Mimics: Synthesis and Antibacterial Activities of Head‐to‐Tail Dimeric SterolPolyamine Conjugates (2013)

Four dimeric sterol-polyamine conjugates have been synthesized from the homo- and hetero-connection of monomeric sterol-polyamine analogs in a head-to-tail manner. These dimeric conjugates show strong antibacterial activity against a broad spectrum of Gram-positive bacteria, whereas their corresponding activities against Gram-negative bacteria are relatively moderate. Though no significant difference was observed in the activities of these conjugates, cholic acid-containing dimeric conjugates generally exhibit higher activities than the corresponding deoxycholic acid-derived analogs. This is in contrast to the finding that a monomeric deoxycholic acid-spermine conjugate was more active than the corresponding cholic acid-derived analog.
Magnetotunneling through stacked InAs/InGaAs/InP self-assembled quantum dots (2007)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation A. G. Silva, P. S. S. Guimarães, S. M. Landi, M. P. Pires, P. L. Souza, G. S. Vieira; Magnetotunneling through stacked InAs/InGaAs/InP self‐assembled quantum dots. AIP Conf. Proc. 10 April 2007; 893 (1): 757–758. https://doi.org/10.1063/1.2730111 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Diplomat, an agent in a multi agent environment: An overview (2003)

A program called Diplomat for playing Diplomacy (a seven-player board game) is described. It is very different from programs that play two-person zero-sum board games (such as chess or checkers) since it must act in an uncertain environment, and it must decide on intermediate goals and explain those to potential allies, or hide those from them. Diplomat is able to make proposals to other powers and can also receive proposals and answer them. In case a player suggests a plan, Diplomat must evaluate it and react accordingly. It must also evaluate the relations between the other players in order to detect potentially dangerous coalitions. Diplomat uses a set of domain-specific heuristics. The experience shows that Diplomat plays in a way that is hard to differentiate from play by humans.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Integrated concurrency control and recovery mechanisms: design and performance evaluation (1985)

In spite of the wide variety of concurrency control and recovery mechanisms proposed during the past decade, the behavior and the performance of various concurrency control and recovery mechanisms remain largely not well understood. In addition, although concurrency control and recovery mechanisms are intimately related, the interaction between them has not been adequately explored. In this paper, we take a unified view of the problems associated with concurrency control and recovery for transaction-oriented multiuser centralized database management systems, and we present several integrated mechanisms. We then develop analytical models to study the behavior and compare the performance of these integrated mechanisms, and we present the results of our performance evaluation.
BiComp-DTA: Drug-target binding affinity prediction through complementary biological-related and compression-based featurization approach (2023)

Drug-target binding affinity prediction plays a key role in the early stage of drug discovery. Numerous experimental and data-driven approaches have been developed for predicting drug-target binding affinity. However, experimental methods highly rely on the limited structural-related information from drug-target pairs, domain knowledge, and time-consuming assays. On the other hand, learning-based methods have shown an acceptable prediction performance. However, most of them utilize several simple and complex types of proteins and drug compounds data, ranging from the protein sequences to the topology of a graph representation of drug compounds, employing multiple deep neural networks for encoding and feature extraction, and so, leads to the computational overheads. In this study, we propose a unified measure for protein sequence encoding, named BiComp, which provides compression-based and evolutionary-related features from the protein sequences. Specifically, we employ Normalized Compression Distance and Smith-Waterman measures for capturing complementary information from the algorithmic information theory and biological domains, respectively. We utilize the proposed measure to encode the input proteins feeding a new deep neural network-based method for drug-target binding affinity prediction, named BiComp-DTA. BiComp-DTA is evaluated utilizing four benchmark datasets for drug-target binding affinity prediction. Compared to the state-of-the-art methods, which employ complex models for protein encoding and feature extraction, BiComp-DTA provides superior efficiency in terms of accuracy, runtime, and the number of trainable parameters. The latter achievement facilitates execution of BiComp-DTA on a normal desktop computer in a fast fashion. As a comparative study, we evaluate BiComp's efficiency against its components for drug-target binding affinity prediction. The results have shown superior accuracy of BiComp due to the orthogonality and complementary nature of Smith-Waterman and Normalized Compression Distance measures for protein sequences. Such a protein sequence encoding provides efficient representation with no need for multiple sources of information, deep domain knowledge, and complex neural networks.
Endogenously produced substance P contributes to lymphocyte proliferation induced by dendritic cells and direct TCR ligation (1999)

Substance P (SP) is an immunoregulatory tachykinin which augments antigen- and mitogen-induced lymphocyte proliferation via signaling through the neurokinin-1 receptor (NK1-R). Non-neuronal cells of the immune system such as monocytes, T lymphocytes and eosinophils can be a source of SP. We have investigated if antigen-presenting dendritic cells (DC) produce SP. DC were grown from bone marrow precursors using a cocktail of GM-CSF, IL-4 and Flt-3 ligand. Reverse transcriptase-PCR amplification using primers for the mouse preprotachykinin-A gene and direct DNA sequencing of amplified products from purified DC demonstrated the presence of the gamma-transcript of the gene, coding for SP and neurokinin A. At the protein level, mouse DC expressed SP as determined by an enzyme immunoassay and confirmed by immunostaining. The functional role of endogenous SP release was determined. During the interaction with syngeneic or allogeneic DC, the addition of a specific NK1-R antagonist partly reduced proliferation in responding T lymphocytes. This was confirmed by using responders derived from NK1-R-deficient mice. In the absence of DC, proliferation of T cells induced by direct TCR ligation and soluble CD28 was partly dependent on signaling through NK1-R, revealing an autocrine effect of SP production by T cells. In conclusion, these results demonstrate that endogenously produced SP contributes to T cell proliferation induced by DC or TCR / CD28 stimulation.
A tunable and reconfigurable active filter based on distributed structure concept (2012)

The filter presented in this article is an active band-pass filter which center frequency and bandwidth can be tuned. It is composed of channels inserted into a distributed structure, and the frequency agility is obtained by activating one or more of them. The concept is validated with measurements realized on a 3-channel prototype structure implemented in a PPH25 GaAs technology. This filter is tunable throughout the X and Ku bands. This first prototype yields encouraging results: the center frequency can be tuned between 9.7 and 14 GHz, with an average gain of 10 dB throughout this range. The filter occupies 13.5 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> of area and consumes 10.5 mA per active stage from a 4V supplying voltage. It is designed for wideband and agile receivers.
A primary rodent triculture model to investigate the role of glia-neuron crosstalk in regulation of neuronal activity (2022)

Abstract Neuroinflammation and hyperexcitability have been implicated in the pathogenesis of neurodegenerative disease, and new models are required to investigate the cellular crosstalk involved in these processes. We developed an approach to generate a quantitative and reproducible triculture system that is suitable for pharmacological studies. While primary rodent cells were previously grown in a coculture medium formulated to support only neurons and astrocytes, we now optimised a protocol to generate tricultures containing neurons, astrocytes and microglia by culturing in a medium designed to support all three cell types and adding exogenous microglia to cocultures. Immunocytochemistry was used to confirm the intended cell types were present. The percentage of ramified microglia in the tricultures decreases as the number of microglia present increases. Multi-electrode array (MEA) recordings indicate that microglia in the triculture model suppress neuronal activity in a dose-dependent manner. Neurons in both cocultures and tricultures were responsive to the potassium channel blocker 4-aminopyridine (4-AP) suggesting that neurons remained viable and functional in the triculture model. Furthermore, suppressed neuronal activity in tricultures correlated with decreased densities of dendritic spines and of the postsynaptic protein Homer1 along dendrites, indicative of a direct or indirect effect of microglia on synapse function. We thus present a functional triculture model, which, due to its more complete cellular composition, is a more relevant model than standard cocultures. The model can be used to probe glia-neuron interactions and subsequently aid the development of assays for drug discovery, using neuronal excitability as a functional endpoint.
New Electromagnetic Interference Shielding Material Demonstrated (1997)

A demonstration electromagnetic interference (EMI) shielding cover that has a potential mass savings in excess of 80 percent over conventional aluminum has been fabricated and tested. It was the culmination of a 3-yr effort involving Hughes Space and Communications (Los Angeles), Applied Sciences, Inc. (Cedarville, Ohio), and the NASA Lewis Research Center. The cover was fabricated from a composite of polycyanate ester resin and graphite fibers that had been chemically modified by intercalation to enhance their electrical conductivity.
A highly non-stationary noise tracking and compensation algorithm, with applications to speech enhancement and on-line ASR (2012)

This paper presents a noise tracking and estimation algorithm for highly non-stationary noises using the Bayesian on-line spectral change point detection (BOSCPD) technique. In BOSCPD, the local minima search window update technique of minima controlled recursive averaging (MCRA) algorithm is made a function of spectral change point detection. The novelty of this algorithm is that it can detect the rapid changes instantly and quickly update the non-stationary noise estimate compared to the MCRA-based algorithms. The BOSCPD algorithm shows improvement in objective quality measures in terms of higher SNR and lower output distortion scores for speech enhancement. It is also tested to track and compensate for rapidly varying noises in on-line automatic speech recognition (ASR) using the Aurora 2 speech database. The simulation results show significant improvement in recognition accuracy compared to the baseline MCRA technique.
Activated charcoal-carboxymethylcellulose gel formulation as an antidotal agent for orally ingested aspirin (1976)

The in vivo effect on aspirin absorption of a potentially more palatable form of activated charcoal was compared to that of a simple aqueous slurry of activated charcoal. The experimental formulation consisted of 20.0 g of activated charcoal, 2.25 g of carboxymethylcellulose (CMC) and 42.8 ml of water; it was tested with and without chocolate syrup as a flavoring agent added just prior to administration. Six subjects were treated in crossover fashion following an aspirin dose of 972 mg. Total urinary excretion of salicylate was measured over 48 hours. Although all three treatments appeared to be effective in reducing the rate and extent of aspirin absorption, the slurry was significantly more effective in reducing the total amount absorbed than the charcoal-CMC gel with chocolate syrup. The slight difference in effectiveness between the gel formulation with and without the chocolate syrup was not significant.
Indirect electrooxidation of alcohols by a double mediatory system with two redox couples of [R2N+:O]/R2NO.cntdot. and [Br.cntdot. or Br+]/Br- in an organic-aqueous two-phase solution (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIndirect electrooxidation of alcohols by a double mediatory system with two redox couples of [R2N+:O]/R2NO.cntdot. and [Br.cntdot. or Br+]/Br- in an organic-aqueous two-phase solutionTsutomu Inokuchi, Sigeaki Matsumoto, and Sigeru ToriiCite this: J. Org. Chem. 1991, 56, 7, 2416–2421Publication Date (Print):March 1, 1991Publication History Published online1 May 2002Published inissue 1 March 1991https://pubs.acs.org/doi/10.1021/jo00007a031https://doi.org/10.1021/jo00007a031research-articleACS PublicationsRequest reuse permissionsArticle Views1299Altmetric-Citations101LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
An emulsion dye laser (1978)

A laser dye which is insoluble in water has been dissolved in hexane and emulsified in a water matrix. When pumped with a nitrogen laser, this mixture was observed to lase. The emulsion is superior to a simple hexane solution because the excellent thermo-optical properties of the water matrix help prevent refractive-index gradients from degrading laser performance. This is a useful characteristic for flash-pumped dye lasers, laser-pumped dye lasers, and liquid filters. Another type of solvent system, a critical solution, is also discussed. For certain dyes, a critical solution has even better thermo-optical properties because of its ability to absorb heat as it undergoes a liquid-liquid phase transition.
Robotic Transaxillary Total Thyroidectomy Using a Unilateral Approach (2011)

There has been a recent interest at performing thyroid procedures robotically through an axillary approach. Although the technique for a unilateral thyroid lobectomy has been well established, there are controversies about whether a unilateral or bilateral axillary approach should be used for total thyroidectomy. Furthermore, there also questions as to whether a robotic total thyroidectomy would be oncologically equivalent to the traditional procedure. We have been performing our robotic total thyroidcetomies through a unilateral axillary approach, using principles learned in traditional surgery for removing substernal goiter. In this report, we describe a technique of robotic unilateral transaxillary total thyroidectomy validated by follow-up radioactive iodine uptake and serum thyroglobulin data.
Effect of Precursor Solubility on the Mechanical Strength of HAP Block (2012)

This chapter contains sections titled: Introduction Materials and Methods Results and Discussion Conclusion Acknowledgements
Oligodeoxynucleotides Containing 2′‐Deoxy‐1‐methyladenosine andDimrothRearrangement (2007)

Abstract 2′‐Deoxy‐1‐methyladenosine was incorporated into synthetic oligonucleotides by phosphoramidite chemistry. Chloroacetyl protecting group and controlled anhydrous deprotection conditions were used to avoid Dimroth rearrangement. Hybridization studies of intramolecular duplexes showed that introduction of a modified residue into the loop region of the oligonucleotide hairpin increases the melting temperature. It was shown that modified oligonucleotides may be easily transformed into oligonucleotides containing 2′‐deoxy‐ N 6 ‐methyladenosine.
Impulse model-based differential expression analysis of time course sequencing data (2018)

Temporal changes to the concentration of molecular species such as mRNA, which take place in response to various environmental cues, can often be modeled as simple continuous functions such as a single pulse (impulse) model. The simplicity of such functional representations can provide an improved performance on fundamental tasks such as noise reduction, imputation and differential expression analysis. However, temporal gene expression profiles are often studied with models that treat time as a categorical variable, neglecting the dependence between time points. Here, we present ImpulseDE2, a framework for differential expression analysis that combines the power of the impulse model as a continuous representation of temporal responses along with a noise model tailored specifically to sequencing data. We compare the simple categorical models to ImpulseDE2 and to other continuous models based on natural cubic splines and demonstrate the utility of the continuous approach for studying differential expression in time course sequencing experiments. A unique feature of ImpulseDE2 is the ability to distinguish permanently from transiently up- or down-regulated genes. Using an in vitro differentiation dataset, we demonstrate that this gene classification scheme can be used to highlight distinct transcriptional programs that are associated with different phases of the differentiation process.
Theoretical studies in heterogeneous combustion (1958)

The theory of the steady-state burning of a single spherically-symmetric liquid monopropellant droplet in an infinite inert atmosphere is formulated. Numerical solutions for the temperature and composition profiles and burning rate are obtained in the case of a one-step chemical reaction of the second order. It is shown that the size and location of the reaction zone depend strongly upon the activation energy. Approximate analytical solutions for the burning rate which are valid for large activation energies are obtained for arbitrary chemical reactions. The results indicate that the mass burning rate is proportional to the droplet radius raised to a power which varies from two at small activation energies to unity at large activation energies.

The Shvab-Zeldovich formulation of the problem of burning of initially unmixed systems is developed and applied to the case of a single fuel droplet burning in an infinite oxidizing atmosphere. Some simplification over other methods for treating this problem is obtained, and the burning rate is shown to be unaffected by a distributed reaction zone when the Lewis number is unity.

A general statistical formalism for describing the behavior of sprays is presented, which includes the effects of droplet growth, the formation of new droplets, collisions and aerodynamic forces. The method is applied to the problem of the determination of the size distribution of a spray formed by the impingement of two streams of droplets of known properties. It is shown that if the two incident jets have a size distribution of a generalized Rosin-Rammler type, then the resulting spray belongs to the same class of distributions. The size history of evaporating sprays is also obtained from the theory. A spray combustion analysis given by Probert is extended to include more general size distributions and the effects of droplet interactions and relative motion of the droplets and the fluid. It is shown that sprays of a uniform size yield the highest combustion efficiency.