gebhart/patrepeval huggingface dataset:
Impact of Magnetron Sputtering Parameters on Thermoelectric Properties of Tungsten-Rhenium Thin-Film Thermocouples Sensor (2018)

In this paper, we present the analysis of the impact of radio frequency magnetron sputtering parameters on the average Seebeck coefficient and maximum reliable working time of thin-film thermocouple (TFTC) sensor based on tungsten-rhenium, and the effect of subsequent optimization of sputtering parameters on the performance of these thermocouples. It can be observed that the repeatability error of TFTCs with magnetron sputtering parameters optimization is ±1.5%, the nonlinear error is ±0.29%, the hysteresis error is ±1.93%, and the average Seebeck coefficient ranges from 26.87 to <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$27.3~\mu \text{V}/^{\circ }\text{C}$ </tex-math></inline-formula> at thermal cycle experiments for 40 h. The electromotive force behavior experiments show optimized TFTCs with protection subjected to a temperature difference of 900 °C is 19.3 mV. Compared with TFTCs without magnetron sputtering parameters optimization and protection, it has improved the thermoelectric properties of tungsten-rhenium TFTCs sensor to be a viable replacement candidate for the requirement of high-temperature measurement.
A tunable 0.5-1.3 GHz CMOS 2nd order bandpass filter with 50Ω input-output impedance matching (2006)

In this paper, a high Q tunable 2nd order band-pass filter, working in the RF frequency range and designed in a standard AMS 0.35mum CMOS technology, is proposed. The filter is based on three different stages that perform the input and output impedance matching, the bandpass function and prevent instabilities; therefore, it is suitable for integrated front-end RF applications. Simulation results have shown a tunable range between 500 MHz and 1.3 GHz with good input and output impedance matching and a low noise figure. Moreover, this circuit presents a compression-point level higher than -22dBm and a quality factor Q higher than 60
Phase II study of transdermal estradiol in androgen‐independent prostate carcinoma (2005)

We read with interest results reported by Bland et al.1 using transdermal estradiol in good performance status androgen independent prostate cancer patients experiencing early relapse and commend the authors' efforts to investigate a strategy for delivering estrogen safely. A median time to progression of 12 weeks was demonstrated with no clinical evidence of thromboembolic events. The authors concluded a low overall activity for the regimen as a secondary hormonal maneuver. Given the current results, we wonder if parenteral estrogen therapy used with systemic chemotherapy in androgen independent prostate cancer would provide for superior survival endpoints instead of a secondary hormonal maneuver alone. Indeed, the current standard in androgen independent stage is largely based on a chemohormonal intervention. The combination of parenteral estrogen with chemotherapy in androgen independent stage is attractive, as the therapeutic advantages of estrogens, such as estrogen mediated apoptosis2 and bone strength preservation, may complement palliative chemotherapy in androgen independent stage. In this regard, we explored the effect of combination parenteral estrogen (intramuscular estradiol valerate) and chemotherapy on coagulation and plasminogen system activation in androgen independent stage in a Phase I trial.3 Our primary goal was to monitor coagulation and plasminogen system activation and was performed by using subclinical markers such as thrombin–antithrombin complex (TAT; reference range,1.0–4.1 μ/L) and quantitative D-dimer levels (QDD, range:0–250 ng/mL) as surrogate markers predictive for thrombohemorrhagic complications. Three escalating doses (10mg, 20 mg, 40 mg) of intramuscular estradiol valerate were administered every 2 weeks in 12 patients. Before each estradiol valerate dose, these markers were measured, and patients with rising levels above baseline measurements were given once daily prophylaxis with 60 mg of low molecular weight heparin. We found that the majority of patients (10 of 12) had subclinical hemostatic activation as measured by rising plasma TAT and QDD levels after estradiol dosing, which returned to patient-specific baseline with daily prophylactic anticoagulation. No clinical thrombosis or hemorrhagic event was observed. Parenteral estrogen administration as shown by Bland et al.1 in the current study and from our results during androgen independent stage is feasible as it does not appear to result in clinically evident thrombosis, but it can result in increased hemostatic activation, especially if combined with chemotherapy. To explore the therapeutic advantages of estrogen therapy not limited to hormonal maneuvers, larger studies will likely need to define a role for prophylactic anticoagulation if estrogens are to be combined with chemotherapy. Manish Kohli M.D.*, * Division of Hematology/Oncology, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, Arkansas
New enhancements in 3G technologies (2005)

Third generation (3G) wireless services are being widely adopted in the global market place with CDMA as the preferred technology solution. So far, the CDMA2000 1X, 1xEV-DO and WCDMA standards have emerged as the main wireless technologies providing high quality voice and high speed data services to the vast majority of current 3G subscribers. The main focus of 3G has been to provide high capacity voice and high downlink data throughput. New enhancements are in order in both major flavors of 3G CDMA standards to enhance the downlink performance and importantly provide significantly capable uplink air interface.
Diurnal variation in continuous measures of the rat EEG power spectra (1992)

EEG measures that vary on a continuous scale, without separating behavior into discrete states, may complement sleep staging as a means of characterizing diurnal variation in level of arousal. The object of the present study was to evaluate diurnal variation in the EEG power spectrum averaged independently of sleep state, and to determine which parameters best reflect this variation. The EEG from rats maintained with chronic cortical electrodes was continuously digitized at 256 Hz, and power spectra computed by fast Fourier transformation every four seconds. Artifact-free spectra occurring over one-hour periods were averaged. Spectral edge, calculated from 66 percent of the area of spectra, and relative power in delta and theta band-widths derived from averaged spectra vary in a consistent and highly significant diurnal pattern. The trend of relative delta power over the daytime, inactive period (when sleep occurs in nocturnal rodents) resembles that seen in human subjects during sleep, with peak levels occurring at the onset, followed by a steady decline during remaining hours of the daytime rest period.
Functions of the WNT Signaling Network in Shaping Host Responses to Infection (2019)

It is well-established that aberrant WNT expression and signaling is associated with developmental defects, malignant transformation and carcinogenesis. More recently, WNT ligands have emerged as integral components of host responses to infection but their functions in the context of immune responses are incompletely understood. Roles in the modulation of inflammatory cytokine production, host cell intrinsic innate defense mechanisms, as well as the bridging of innate and adaptive immunity have been described. To what degree WNT responses are defined by the nature of the invading pathogen or are specific for subsets of host cells is currently not well-understood. Here we provide an overview of WNT responses during infection with phylogenetically diverse pathogens and highlight functions of WNT ligands in the host defense against infection. Detailed understanding of how the WNT network orchestrates immune cell functions will not only improve our understanding of the fundamental principles underlying complex immune response, but also help identify therapeutic opportunities or potential risks associated with the pharmacological targeting of the WNT network, as currently pursued for novel therapeutics in cancer and bone disorders.
Dispersion of waves in piano strings (1988)

A recent survey of piano acoustics literature revealed an apparent lack of attention to various aspects of dispersion in piano strings, apart from some information on its effect on inharmonicity of piano tone partials. In this article, it will be shown how group velocity of transverse waves in piano strings can be measured as a function of frequency with the aid of a short-time spectral analysis method. Examples of group velocity measurements appear to be essentially in agreement with the theoretical predictions based on a model of a flexurally stiff string. In addition, the relationship between the group and phase velocity, as a function of frequency, is also illustrated, indicating correspondence between theoretical predictions and experimental results. A short-time spectral analysis of transverse string displacement as a function of time, monitored near the bridge, has revealed a quasiperiodic succession of frequency glides. This effect is due to dispersion and is particularly prominent in the lowest bass strings. However, the same type of analysis applied to the sound-pressure signal of the corresponding radiated sound yielded somewhat different results. While frequency glides similar to those found in the string displacement spectra were partly evident in the sound-pressure spectra, strong precursive components of longitudinal string vibration origin were found to dominate the higher frequency portion of the attack transient of the radiated sound.
Deletion of the NR2A subunit prevents developmental changes of NMDA‐mEPSCs in cultured mouse cerebellar granule neurones (2005)

We investigated the role N-methyl-d-aspartate (NMDA) receptor subunits play in shaping excitatory synaptic currents in cultures of cerebellar granule cells (CGCs) from NR2A knockout (NR2A-/-) and wild-type (+/+) mice. Cultures were maintained in a condition that facilitates the occurrence of functional synapses, allowing us to record NMDA-miniature excitatory postsynaptic currents (mEPSCs) in addition to NMDA receptor-mediated whole-cell currents at three ages in vitro. Whole-cell NMDA current density decreased with development in both strains though currents from NR2A-/- neurones demonstrated greater sensitivity to CP101 606, an NR2B subunit specific blocker. Sensitivity to Mg(2+) blockade decreased with age in vitro in +/+ but not in NR2A-/- CGCs. Immunocytochemistry revealed that dendrites and somas displayed distinct NR1 and NR2A subunit clusters which became increasingly colocalized in +/+ neurones. Qualitatively the overall NR2B subunit staining pattern was similar in +/+ and NR2A-/- neurones throughout development, suggesting that the NR2B subunit distribution is not mediated by the NR2A subunit. In addition, staining with markers for excitatory synapses showed that expression of NR2A subunit (but not NR2B) increases at both synaptic and extrasynaptic sites in +/+ neurones during development. In parallel, NMDA-mEPSCs were faster in +/+ compared with NR2A-/- neurones at all time points studied, suggesting that the NR2A subunit begins to replace NR2B-rich NMDA receptors even at early stages of development. Many NR2A-/- neurones were devoid of NMDA-mEPSCs at the later time point, and transfection of the NR2A subunit in these neurones restored fast decay and the occurrence of NMDA-mEPSCs. Taken together, our results indicate that the NR2A subunit is mainly responsible for the developmental changes observed in the maturation of excitatory synapses.
Efficient sequence alignment of network traffic (2006)

String comparison algorithms, inspired by methods used in bioinformatics, have recently gained popularity in network applications. In this paper we demonstrate the need for careful selection of alignment models if such algorithms are to yield the desired results when applied to network traffic. We introduce a novel variant of the Jacobson-Vo algorithm employing a flexible gap-minimising alignment model suitable for network traffic, and find that our software implementation outperforms the commonly used Smith-Waterman approach by a factor of 33 on average and up to 58.5 in the best case on a wide range of network protocols.
Yield, water use efficiency, and yield response factor in carrot crop under different irrigation depths (2016)

ABSTRACT: The aim of the present study was to evaluate the effect of different irrigation depths on the yield, water use efficiency (WUE), and yield response factor (Ky) of carrot (cv. 'Brasília') in the edaphoclimatic conditions of Baixada Fluminense, RJ, Brazil. Field trials were conducted in a Red-Yellow Argisol in the 2010-2011period. A randomized block design was used, with 5 treatments (depths) and 4 replicates. Depths were applied by drippers with different flow rates, and the irrigation was managed by time domain reflectometry (TDR) technique. The reference (ETo) and crop (ETc) evapotranspiration depths reached 286.3 and 264.1mm in 2010, and 336.0 and 329.9mm in 2011, respectively. The root yield varied from 30.4 to 68.9t ha-1 as a response to treatments without irrigation and 100% replacement of the soil water depth, respectively. Values for WUE in the carrot crop varied from 15 to 31kg m-3 and the mean Ky value was 0.82. The mean values for Kc were obtained in the initial (0.76), intermediate (1.02), and final (0.96) stages. Carrot crop was influenced by different water depths (treatments) applied, and the highest value for WUE was obtained for 63.4% of soil water replacement.
Effects of endogenous endothelial interleukin-8 on neutrophil migration across an endothelial monolayer (1995)

Endogenous endothelial IL-8, secreted from activated endothelial cells into the apical side of endothelial cell monolayers, has an inhibitory effect on transendothelial migration of neutrophils, suggesting that IL-8 may prevent excessive neutrophil infiltration of myocardial tissue from circulating blood in the reperfusion injury associated with acute myocardial infarction.
Antiapoptotic and antiautophagic effects of glial cell line‐derived neurotrophic factor and hepatocyte growth factor after transient middle cerebral artery occlusion in rats (2010)

Glial cell line-derived neurotrophic factor (GDNF) and hepatocyte growth factor (HGF) are strong neurotrophic factors, which function as antiapoptotic factors. However, the neuroprotective effect of GDNF and HGF in ameliorating ischemic brain injury via an antiautophagic effect has not been examined. Therefore, we investigated GDNF and HGF for changes of infarct size and antiapoptotic and antiautophagic effects after transient middle cerebral artery occlusion (tMCAO) in rats. For the estimation of ischemic brain injury, the infarct size was calculated at 24 hr after tMCAO by HE staining. Terminal deoxynucleotidyl transferase-mediated dUTP-biotin in situ nick end labeling (TUNEL) was performed for evaluating the antiapoptotic effect. Western blot analysis of microtubule-associated protein 1 light chain 3 (LC3) and immunofluorescence analysis of LC3 and phosphorylated mTOR/Ser(2448) (p-mTOR) were performed for evaluating the antiautophagic effect. GDNF and HGF significantly reduced infarct size after cerebral ischemia. The amounts of LC3-I plus LC3-II (relative to beta-tubulin) were significantly increased after tMCAO, and GDNF and HGF significantly decreased them. GDNF and HGF significantly increased p-mTOR-positive cells. GDNF and HGF significantly decreased the numbers of TUNEL-, LC3-, and LC3/TUNEL double-positive cells. LC3/TUNEL double-positive cells accounted for about 34.3% of LC3 plus TUNEL-positive cells. This study suggests that the protective effects of GDNF and HGF were greatly associated with not only the antiapoptotic but also the antiautophagic effects; maybe two types of cell death can occur in the same cell at the same time, and GDNF and HGF are capable of ameliorating these two pathways.
Cultured Cell Sublines Highly Susceptible to Prion Infection (2000)

Cultured cell lines infected with prions produce an abnormal isoform of the prion protein (PrP(Sc)). In order to derive cell lines producing sufficient quantities of PrP(Sc) for most studies, it has been necessary to subclone infected cultures and select the subclones producing the largest amounts of PrP(Sc). Since postinfection cloning can introduce differences between infected and uninfected cell lines, we sought an approach to generate prion-infected cell lines that would avoid clonal artifacts. Using an improved cell blot technique, which permits sensitive and rapid comparison of PrP(Sc) levels in multiple independent cell cultures, we discovered marked heterogeneity with regard to prion susceptibility in tumor cell sublines. We exploited this heterogeneity to derive sublines which are highly susceptible to prion infection and used these cells to generate prion-infected lines without further subcloning. These infected sublines can be compared to the cognate uninfected cultures without interference from cloning artifacts. We also used susceptible cell lines and our modified cell blot procedure to develop a sensitive and reproducible quantitative cell culture bioassay for prions. We found that the sublines were at least 100-fold more susceptible to strain RML prions than to strain ME7 prions. Comparisons between scrapie-susceptible and -resistant cell lines may reveal factors that modulate prion propagation.
Automated mitosis detection in histopathology using morphological and multi-channel statistics features (2013)

The proposed multi-channel features computation scheme uses fixed image scale and extracts nuclei features in selected channels of various color spaces. This simple but robust model has proven to be highly efficient in capturing multi-channels statistical features for mitosis detection, during the MITOS international benchmark. Indeed, the mitosis detection of critical importance in cancer diagnosis is a very challenging visual task. In future work, we plan to use color deconvolution as preprocessing and Hough transform or local extrema based candidate detection in order to reduce the number of candidates in mitosis and non-mitosis classes.
Correlation-Induced Conductance Suppression at Level Degeneracy in a Quantum Dot (2010)

The large, level-dependent g factors in an InSb nanowire quantum dot allow for the occurrence of a variety of level crossings in the dot. While we observe the standard conductance enhancement in the Coulomb blockade region for aligned levels with different spins due to the Kondo effect, a vanishing of the conductance is found at the alignment of levels with equal spins. This conductance suppression appears as a canyon cutting through the web of direct tunneling lines and an enclosed Coulomb blockade region. In the center of the Coulomb blockade region, we observe the predicted correlation-induced resonance. Our findings are supported by numerical and analytical calculations.
A new HLA‐Cw*15 allele, Cw*1508, identified in the Peruvian population (1999)

A novel HLA-Cw*15 allele , Cw*1508, has been found in the Peruvian population. This new allele, initially detected as a polymerase chain reaction with sequence-specific primers (PCR-SSP) variant, shows greatest similarity to Cw*1502. The nucleotide sequence of Cw*1508 only differs from that of Cw*1502 at position 539; this change determines the replacement of Leu by Arg 156 in Cw*1508.
A method for coupling phasor and time domain networks (2010)

A method for coupling dynamic phasor models to time domain resistive companion networks is proposed for power system simulation. The method uses controlled sources, modified nodal analysis, and a discrete Fourier transform (DFT) phasor estimation. A coupling device using this technique is implemented in Virtual Test Bed (VTB). The accuracy and stability of the method is verified with two test systems, including a system consisting of a phasor electrical network attached to a three phase induction motor. The hybrid simulations produce exact steady-state results, nearly exact results for slow transients (on the order of 10 cycles), and good approximations for faster transients (on the order of 1 cycle). Unbalanced fault conditions are also simulated with satisfactory results.
A Simple Word Embedding Model for Lexical Substitution (2015)

The lexical substitution task requires identifying meaning-preserving substitutes for a target word instance in a given sentential context. Since its introduction in SemEval-2007, various models addressed this challenge, mostly in an unsupervised setting. In this work we propose a simple model for lexical substitution, which is based on the popular skip-gram word embedding model. The novelty of our approach is in leveraging explicitly the context embeddings generated within the skip-gram model, which were so far considered only as an internal component of the learning process. Our model is efficient, very simple to implement, and at the same time achieves state-ofthe-art results on lexical substitution tasks in an unsupervised setting.
Fräsergeometriekorrektur an der Steuerung für das fünfachsige NC-Fräsen von Freiformflächen (1988)

Article Fräsergeometriekorrektur an der Steuerung für das fünfachsige NC-Fräsen von Freiformflächen was published on December 1, 1988 in the journal Zeitschrift für wirtschaftlichen Fabrikbetrieb (volume 83, issue 12).
Feasibility study of a dedicated nuclear desalination system: Low-pressure Inherent heat sink Nuclear Desalination plant (LIND) (2015)

In this paper, we suggest the conceptual design of a water-cooled reactor system for a low-pressure inherent heat sink nuclear desalination plant (LIND) that applies the safety-related design concepts of high temperature gas-cooled reactors to a water-cooled reactor for inherent and passive safety features. Through a scoping analysis, we found that the current LIND design satisfied several essential thermal–hydraulic and neutronic design requirements. In a thermal–hydraulic analysis using an analytical method based on the Wooton–Epstein correlation, we checked the possibility of safely removing decay heat through the steel containment even if all the active safety systems failed. In a neutronic analysis using the Monte Carlo N-particle transport code, we estimated a cycle length of approximately 6 years under 200 MWth and 4.5% enrichment. The very long cycle length and simple safety features minimize the burdens from the operation, maintenance, and spent-fuel management, with a positive impact on the economic feasibility. Finally, because a nuclear reactor should not be directly coupled to a desalination system to prevent the leakage of radioactive material into the desalinated water, three types of intermediate systems were studied: a steam producing system, a hot water system, and an organic Rankine cycle system.
Anti-leukemia effect of vitamin K3 is mediated through mitochondrial complexes I and II (2019)

The discovery of all-trans retinoic acid (ATRA) and its introduction into clinical therapy revolutionized treatment of acute promyelocytic leukemia (APL), a subtype of acute myeloid leukemia (AML) ...
EMI: Theory, coupling mechanisms, equivalent circuits, and solutions (2011)

The paper presents an outline of the following:EMI definitions, fundamentals, issues, concerns; path of lowest impedance; common impedance, H-field, E-field, radiation; theory of noise coupling; videotaped EMI demonstrations; equivalent circuits and EMI abatement methods; and circuit board and system layout principles.