gebhart/patrepeval huggingface dataset:
Supported metal nanoparticles on porous materials. Methods and applications (2008)

Nanoparticles are regarded as a major step forward to achieving the miniaturisation and nanoscaling effects and properties that have been utilised by nature for millions of years. The chemist is no longer observing and describing the behaviour of matter but is now able to manipulate and produce new types of materials with specific desired physicochemical characteristics. Such materials are receiving extensive attention across a broad range of research disciplines. The fusion between nanoparticle and nanoporous materials technology represents one of the most interesting of these rapidly expanding areas. The harnessing of nanoscale activity and selectivity, potentially provides extremely efficient catalytic materials for the production of commodity chemicals, and energy needed for a future sustainable society. In this tutorial review, we present an introduction to the field of supported metal nanoparticles (SMNPs) on porous materials, focusing on their preparation and applications in different areas.
Real-time detection of single atoms with transverse mode of high-finesse optical micro cavity (2005)

Summary form only given. The strong atom-photon coupling generated inside high-finesse optical micro cavity lets us detect a single atom trajectory in real time. Such a strong coupling is a candidate for trapping a single atom with a single photon. Dynamics of trapped atoms can be observed in situ and in real time by detecting intensity change on the transmission of a blue-shifted laser beam. We cooled down and trapped rubidium atoms by using conventional cell magneto optical trap (MOT) and launched them into the micro optical cavity which locates 35 mm above the MOT. By using this signal as trigger and changing the laser frequency, it is, in principle, possible to trap the atom in the cavity.
Toward Encoding Vision-to-Touch With Convolutional Neural Networks (2019)

The task of encoding visual information into tactile information has been studied since the 1960s. There is still an open challenge in converting the data of an image into a small set of signals that will be sent to the user as tactile input. In this study, we evaluated two methods that have never been used for encoding vision-to-touch using convolutional neural networks, a bag of convolutional features (BoF) and a vector of locally aggregated descriptors (VLAD). We also present here a very new method for evaluating the semantic property of the encoded signal by taking the idea that objects with similar features must have similar signals in the tactile interface; we created a semantic property evaluation (SPE) metric. Using this metric, we proved the advantage of using the BoF and VLAD methods, obtaining an SPE of 70.7% and 64.5%, respectively, which is a considerable improvement over the downscaling method used by many systems such as BrainPort, with 56.2%.
Electrical properties of planar AlGaN/GaN Schottky diodes: Role of 2DEG and analysis of non-idealities (2017)

A detailed study of the electrical properties of planar AlGaN/GaN Schottky diodes is presented, the focus being on the role of the two dimensional electron gas (2DEG) depletion and the diodes non-idealities in different voltage regimes. The 2DEG depletion behavior is inferred from the analysis of capacitance and current measurements with transition from vertical to lateral diode operation occurring at Vpinch-off = 4 V. In particular, the sub-micrometer depletion width, laterally extending from the edge of the Schottky contact under high reverse voltages, is evaluated on the basis of a simple fringe capacitance model. Current transport mechanisms are discussed, investigating the interrelation between 2DEG, Poole-Frenkel effect, and defects. With regard to defects, the role of dislocations in the AlGaN/GaN diode non-idealities, usually interpreted in terms of Schottky barrier inhomogeneities, is critically addressed. Photocurrent spatial mapping under high reverse voltage points out the not uniform electric field distribution around the Schottky contact and highlights the presence of local photo-conductive paths, likely associated with the dislocations near the edge of the Schottky contact.
Characterizing the population of pulsars in the inner Galaxy with the Fermi Large Area Telescope (2017)

An excess of $γ$-ray emission from the Galactic Center (GC) region with respect to predictions based on a variety of interstellar emission models and $γ$-ray source catalogs has been found by many groups using data from the {\it Fermi} Large Area Telescope (LAT). Several interpretations of this excess have been invoked. In this paper we search for members of an unresolved population of $γ$-ray pulsars located in the inner Galaxy that are predicted by the interpretation of the GC excess as being due to a population of such sources. We use cataloged LAT sources to derive criteria that efficiently select pulsars with very small contamination from blazars. We search for point sources in the inner $40^\circ\times40^\circ$ region of the Galaxy, derive a list of approximately 400 sources, and apply pulsar selection criteria to extract pulsar candidates among our source list. We performed the entire data analysis chain with two different interstellar emission models (IEMs), and found a total of 135 pulsar candidates, of which 66 were selected with both IEMs.
Initiation from a point anode in a dielectric liquid (2007)

For original paper see Kim and Hebner, ibid., vol.13, p.1254 (2006). In this discussion, the initiation of a positive streamer from the tip-electrode when a high voltage is applied to a tip-plane measurement cell filled with cyclohexane is discussed. The authors suggest that the initiating process is the formation of electron avalanches near the positive tip. In the present case the high field is concentrated around the tip anode. Fermi level of the metal electrode is energetically located in the middle of the forbidden gap of cyclohexane, electrons from molecules adsorbed at the surface of the tip and of adjacent layers can tunnel into the metal giving rise to the injection of positive charges. This process is called field ionization and has been invoked in the explanation of injection currents in liquids. In liquid cyclohexane strong incoherent scattering prevents the formation of a Rydberg state. Mean free path for electrons in cyclohexane changes by about three orders of magnitude between a thermal energy situation and one in which there is energy available to electrons due to electric fields with magnitudes like those under the conditions studied. So, our postulate was based on consideration of the dynamic properties rather than the equilibrium properties. The discussion of the model stating that the experimental results were consistent with such a model, and ended by characterizing the model as a framework in which experimental results can be reconciled. Kim and Hebner reply to the comments.
Triple boundary multiphase with predictive interleaving technique for switched capacitor DC-DC converter regulation (2014)

In this paper, we propose a new technique to regulate multi-phase interleaved switched-capacitor DC-DC converters. Traditionally, SC converters are either regulated by modulating the switching frequencies directly through a voltage-controlled-oscillator or by using hysteretic control where separate control loops are used for each converter core. Achieving fast regulation by modulating VCO is difficult because it requires a high speed error amplifier and proper loop compensation. Conventional hysteretic controller achieves fast regulation, but it uses N comparators or one shared comparator that operates at N times the single phase switching frequency, where N is the level of interleaving. The proposed technique avoids these problems by using triple boundary hysteretic control, where one comparator is used for defining the reference voltage, and the other two comparators enable coarse/fine operation to achieve both fast recovery and tight regulation.
On the Interfacial Behavior of Catenated Poly(l-lactide) at the Air–Water Interface (2022)

Interfacial properties of polymeric materials are significantly influenced by their architectural structures and spatial features, while such a study of topologically interesting macromolecules is rarely reported. In this work, we reported, for the first time, the interfacial behavior of catenated poly(l-lactide) (C-PLA) at the air-water interface and compared it with its linear analogue (L-PLA). The isotherms of surface pressure-area per repeating unit showed significant interfacial behavioral differences between the two polymers with different topologies. Isobaric creep experiments and compression-expansion cycles also showed that C-PLA demonstrated higher stability at the air-water interface. Interestingly, when the films at different surface pressures were transferred via the Langmuir-Blodgett method, successive atomic force microscopy imaging displayed distinct nanomorphologies, in which the surface of C-PLA exhibited nanofibrous structures, while that of the L-PLA revealed a smoother topology with less fiber-like structures.
Unique Diagnostic and Therapeutic Roles of Porphyrins and Phthalocyanines in Photodynamic Therapy, Imaging and Theranostics (2012)

Porphyrinic molecules have a unique theranostic role in disease therapy; they have been used to image, detect and treat different forms of diseased tissue including age-related macular degeneration and a number of different cancer types. Current focus is on the clinical imaging of tumour tissue; targeted delivery of photosensitisers and the potential of photosensitisers in multimodal biomedical theranostic nanoplatforms. The roles of porphyrinic molecules in imaging and pdt, along with research into improving their selective uptake in diseased tissue and their utility in theranostic applications are highlighted in this Review.
F-box protein interactions with the hallmark pathways in cancer (2015)

F-box proteins (FBP) are the substrate specifying subunit of Skp1-Cul1-FBP (SCF)-type E3 ubiquitin ligases and are responsible for directing the ubiquitination of numerous proteins essential for cellular function. Due to their ability to regulate the expression and activity of oncogenes and tumour suppressor genes, FBPs themselves play important roles in cancer development and progression. In this review, we provide a comprehensive overview of FBPs and their targets in relation to their interaction with the hallmarks of cancer cell biology, including the regulation of proliferation, epigenetics, migration and invasion, metabolism, angiogenesis, cell death and DNA damage responses. Each cancer hallmark is revealed to have multiple FBPs which converge on common signalling hubs or response pathways. We also highlight the complex regulatory interplay between SCF-type ligases and other ubiquitin ligases. We suggest six highly interconnected FBPs affecting multiple cancer hallmarks, which may prove sensible candidates for therapeutic intervention.
Expression of human P450C17 as an export protein insaccharomyces cerevisiae (1995)

Cytochrome P450c17 (P450c17), together with cytochrome P450c21 (P450c21), plays an important role in progesterone metabolism in the mammalian adrenal cortex. Low levels of expression and the presence of other steroidogenic enzymes in adrenal cortex endoplasmic reticulum (ER) impedes purification and characterisation of wild type as well as mutant forms of the hemoprotein. Heterologous gene expression systems have previously been used successfully to express active P450c17. Heterologous expression can also be used for the preparation of anti-P450c17-IgG. For antibody production larger amounts of pure P450c17 peptide, rather than the active protein, is, however, desirable. If the expressed protein can be affinity tagged and secreted into the medium, isolation and purification will be facilitated. Saccharomyces cerevisiae, YPH259, was transformed with a modified YCplac111 yeast expression-secretion vector (pPRL2). The gene coding for a truncated human P450c17 (signal anchor sequence 1-18 was removed) was inserted, in reading frame, downstream from the leader sequence MF alpha. A histidine tag was incorporated at the C-terminus. The modified yeast expression vector was expressed in yeast, the secreted P450c17-peptide purified by affinity chromatography and identified by immunoblot analysis.
Collaborative Strategies for the Search of 3-D Targets in Molecular Environments (2012)

Collaborative virtual environments introduce new working methods allowing for the association of several experts in the same problem-solving process. These new platforms have the potential to improve the processing of complex environments with large amounts of data and require different skills. This paper proposes the study of a synchronous and colocated approach for molecular design tasks. More precisely, this study focuses on the collaborative search of targets during the molecular deformation process. The aim of this paper is to highlight the different working strategies that emerge according to different tasks and humans factors. Based on these working strategies, we propose to investigate the contribution of collaborative configurations of work according to different efficiency criteria such as the completion time, verbal communication, and manipulation distance. Finally, this study will highlight some issues related to conflict of actions, concurrent access, awareness, and communication processes.
Serum levels of fibroblast growth factor‐21 are increased in chronic and acute renal dysfunction (2013)

We demonstrate that circulating FGF-21 is increased in both CKD and AKD. Our results suggest renal excretion as a major route for FGF-21 elimination. The pathophysiological significance of these findings needs to be elucidated in more detail.
Creep Life Assessment Method for Super304H Boiler Tubes Based on HTS-SQUID Gradiometer (2023)

This paper presents a novel method for the creep life assessment of Super304H (KA-SUS304J1HTB, ASME code: 2328) boiler tubes based on a discrete-type eddy-current-testing (ECT) HTS-SQUID nondestructive evaluation (NDE) system. Six specimens were subjected to internal pressure creep tests at a stress level of 110 MPa and a temperature of 700 °C. The specimens were inspected at various creep test times using our NDE system, which included an ECT probe and a HTS-SQUID gradiometer. By studying the physical characteristics and microstructures of the specimens at different test times, we found that the electrical conductivity and permeability of the specimens varied with an increasing test time. The detected signals may have been generated from creep voids and/or surface microcracks. Based on the NDE inspection results, creep life assessment curves that can be used for assessing the remaining creep life of the Super304H boiler tubes were plotted. The results confirmed the possibility of assessing the remaining creep life using our HTS-SQUID-based system in a nondestructive manner.
Kinetic Modeling of Rhodium‐Catalyzed Reductive Amination of Undecanal in Different Solvent Systems (2020)

Abstract The homogenously rhodium‐catalyzed reductive amination of 1‐undecanal was performed in two different thermomorphic solvent systems with the ligand Xantphos. The influences of partial pressure, temperature, methanol and catalyst concentration on the reaction were investigated. Based on a network analysis a kinetic model was derived and successfully parametrized for all studied solvent systems. Simulation results were found to be in good agreement with the experiments and allow a further process development and optimization.
Development and evaluation of a 6DOF interface to be used in a medical application (2002)

This thesis was performed at the research centre CINECA in Bologna, Italy. An interface with six degrees of freedom, 6DOF, to be used in a virtual environ- ment for the positioning of medical components was developed in co-operation with IOR, one of the most important orthopaedic hospitals in Italy. The main reason for doing this was to find out whether or not a virtual en-viron-ment and 6DOF interaction could make the pre-operative planning of an ope-ration more efficient compared to other techniques. Is it easy to posi-tion an object using stereovision and a 6DOF tracker tool? Further-more, the interface might also be used in other applications and areas in the future. Described is the development of an interaction class especially constructed for the use of a tracking tool called a stylus pen. This tool takes advantage of all 6DOF, i.e. it recognises movements in the x, y and z directions and likewise the orientation of the tool around the three axis. Moreover, an application which uses the interaction class was created in order to evaluate its usefulness. The application enables the user to load, save and position objects within a virtual environment. The result of this evaluation is then described and discussed. In the evaluations it was shown that the stylus pen with 6DOF is an intuitive in-ter-action tool which works well for positioning. The stereovision also seems to further improve the users ability to position objects. However, the created interaction class needs to be further developed before itcan be implemented in a pre-operative planning tool.
Iodoarene-catalyzed oxidative transformations using molecular oxygen (2017)

Molecular oxygen serves as a useful oxidant for the glycol scission of 1,2-diols and the Hofmann rearrangement of primary amides using pentamethyliodobenzene as a catalyst. The use of isobutyraldehyde and Lewis basic nitriles under O<sub>2</sub> enabled the iodine(i)/(iii) catalytic cycle, where in situ-generated peracid acts as a terminal oxidant.
The Role of Optics in Computation (1986)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text RAVINDRA A. ATHALE, "The Role of Optics in Computation," Optics News 12(4), 18-20 (1986) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Identification and Characterization of Mouse Cochlear Stem Cells (2006)

Genetic, noise- and drug-induced loss of hair cells in the mouse and human cochlea leads to permanent hearing loss due to lack of regeneration of hair cells, which may be due to reduced numbers or loss of the regenerative ability of stem cells in the adult cochlea. We hypothesized that the mouse neonate cochlea harbors stem cells capable of differentiating into hair cells. Cells from the primary neonate cochlear culture began to proliferate and formed floating spheres after 14 days in vitro (DIV). By comparison, spheres from the primary culture of the cortex were observed after 7 DIV. Cochlear sphere cells could be passaged and the new spheres were observed after 7 DIV. Cochlear sphere cells were capable of differentiating into astrocytes and oligodendrocytes, but not neurons under the conditions tested. Cochlear sphere cells expressed Sox2 and Myo7a, but failed to show markers that are expressed exclusively in mature cochlear tissue, while cells from cortex spheres expressed Sox2 and Otx2, but not Myo7a. Our results show that cochleae from neonatal mice harbor cells capable of forming spheres and cells from these spheres appear to be better endowed to become hair cells.
Efficacy of varicella (VZV) vaccination: an update for the clinician (2016)

Varicella-zoster virus (VZV) infection causes two distinct clinical conditions. Primary varicella infection results in chickenpox, a contagious rash illness typically seen among children. VZV can reactivate years after the initial infection to cause herpes zoster (HZ) and lead to post-herpetic neuralgia, a common complication resulting in persistent pain that may last for years after the zoster rash resolves. A person's risk of having longer lasting and more severe pain associated with HZ increases with age. Since the introduction of VZV vaccines, the rates of infection, hospitalizations, and mortality have declined. In this review, we discuss in detail current VZV vaccines available for the prevention of VZV and HZ infections. Varilrix (GSK Biologicals, UK), Varivax (Merck, USA) and the combined measles, mumps, rubella, and varicella (MMRV) vaccine contain the live attenuated Oka strain of VZV for routine varicella vaccination. While Zostavax is the only HZ vaccine currently approved for use in the United States and the European Union [EMEA, 2011], a subunit vaccine candidate called HZ/su has recently shown improved efficacy for zoster prevention in two clinical trial phase III studies. VariZIG, a post-exposure prophylactic, uses zoster immune globulin to prevent VZV infection in those who have recently been in contact with VZV but lack evidence of varicella immunity and are contraindicated to receive the varicella vaccine. Further, we discuss the skin tropic and neurotropic factor VZV ORF7 gene and its involvement in varicella infection, reactivation and latency in ganglia. Ultimately, these studies can contribute to the development of a neuroattenuated vaccine candidate against varicella or a vector for delivery of other virus antigens.
Growth and characterization of GaSb/AlSb multiple quantum well structures on Si(111) and Si(001) substrates (2010)

For the purpose of investigating their structural and optical properties, GaSb thin films and GaSb/AlSb multiple quantum well (MQW) structures were grown on Si(111) substrates. A GaSb/AlSb MQW structure was also grown on Si(001) substrate as a control sample. Surface morphologies and a XRD measurements of GaSb films grown on Si(111) substrates showed that the GaSb film with a 5 nm thick AlSb initiation layer has good crystal quality. Observation of the RHEED patterns of both MQWs suggests that both GaSb films are under tensile strain at growth temperature. In-plane XRD measurement of MQW on Si(111) showed that the (111) face of the GaSb film is aligned to the Si(111) surface upon rotation by 30°. Photoluminescence (PL) spectra consisting of two peaks at 1250∼1400 nm were observed for both MQWs.
The impact of radioimmunoguided surgery (RIGSTM) on surgical decision-making in colorectal cancer (1989)

Radioimmunoguided surgery (RIGS system) was performed in ten patients with rectal or low sigmoid colon carcinoma with the use of a hand-held gamma detector (Neoprobe 1000) intraoperatively and externally after injection of radiolabeled (125I) monoclonal antibody to detect pelvic and metastatic tumor. Fifteen procedures, including six exploratory laparotomies, four transperineal explorations, two transsacral explorations, one transvaginal biopsy, one brachytherapy, and one transanal polypectomy, were performed. Two patients had previous low anterior resection, seven abdominoperineal resection, and one a rectal polypectomy. Five patients had previous pelvic radiation therapy. Reoperation was indicated by elevated CEA levels in seven patients (70 percent), persistent pelvic pain in six (60 percent), and a suspicious radiologic study in seven (70 percent). RIGS system localized tumors verified by histopatholoy in all ten patients (100 percent); one patient with a positive CT scan and probe findings lacked histopathologic confirmation on frozen section, but had a tumor confirmed on permanent histology. Five major abdominal operations were avoided; in five patients major modifications were made in the surgical procedure based on probe findings. Six received chemotherapy or radiation therapy based on findings of the RIGS system. In six patients with negative or equivocal CT scans, the RIGS system localized histopathologically confirmed tumor. Major abdominal procedures can be avoided, the surgical approach modified, and other modes of therapy instituted earlier with the use of the RIGS system.