gebhart/patrepeval huggingface dataset:
Testing of a 7-tube palladium membrane reactor for potential use in TEP (2010)

A Palladium Membrane Reactor (PMR) consists of a palladium/silver membrane permeator filled with catalyst (catalyst may be inside or outside the membrane tubes). The PMR is designed to recover tritium from the methane, water, and other impurities present in fusion reactor effluent. A key feature of a PMR is that the total hydrogen isotope content of a stream is significantly reduced as (1) methane-steam reforming and/or water-gas shift reactions proceed on the catalyst bed and (2) hydrogen isotopes are removed via permeation through the membrane. With a PMR design matched to processing requirements, nearly complete hydrogen isotope removals can be achieved. A 3-tube PMR study was recently completed. From the results presented in this study, it was possible to conclude that a PMR is appropriate for TEP, perforated metal tube protectors function well, platinum on aluminum (PtA) catalyst performs the best, conditioning with air is probably required to properly condition the Pd/Ag tubes, and that CO/CO{sub 2} ratios maybe an indicator of coking. The 3-tube PMR had a permeator membrane area of 0.0247 m{sup 2} and a catalyst volume to membrane area ratio of 4.63 cc/cm{sup 2} (with the catalyst on the outside of the membrane tubes and the catalyst only covering the membrane tube length). A PMR for TEP will require a larger membrane area (perhaps 0.35 m{sup 2}). With this in mind, an intermediate sized PMR was constructed. This PMR has 7 permeator tubes and a total membrane area of 0.0851 m{sup 2}. The catalyst volume to membrane area ratio for the 7-tube PMR was 5.18 cc/cm{sup 2}. The total membrane area of the 7-tube PMR (0.0851 m{sup 2}) is 3.45 times larger than total membrane area of the 3-tube PMR (0.0247 m{sup 2}). The following objectives were identified for the 7-tube PMR tests: (1) Refine test measurements, especially humidity and flow; (2) Refine maintenance procedures for Pd/Ag tube conditioning; (3) Evaluate baseline PMR operating conditions; (4) Determine PMR scaling method; (5) Evaluate PMR with realistic feed compositions; (6) Evaluate PMR performance with varying permeate pressures; (7) Study coking-related issues; and (8) Identify any unexpected behavior that may require further investigation (used to study transient behavior). This report presents the tests results defined by these objectives.
Influence of Vanillin Acrylate-Based Resin Composition on Resin Photocuring Kinetics and Antimicrobial Properties of the Resulting Polymers (2021)

The investigation of the influence of vanillin acrylate-based resin composition on photocuring kinetics and antimicrobial properties of the resulting polymers was performed in order to find efficient photocurable systems for optical 3D printing of bio-based polymers with tunable rigidity, as well as with antibacterial and antifungal activity. Two vanillin derivatives, vanillin diacrylate and vanillin dimethacrylate, were tested in photocurable systems using phenyl bis(2,4,6-trimethylbenzoyl)phosphine oxide as a photoinitiator. The influence of vanillin acrylate monomer, amount of photoinitiator, presence and amount of dithiol, and presence of solvent on photocuring kinetics was investigated by real-time photoreometry. Polymers of different rigidity were obtained by changing the photocurable resin composition. The photocuring kinetics of the selected vanillin acrylate-based resins was comparable with that of commercial petroleum-based acrylate resins for optical 3D printing. Polymers based on both vanillin acrylates showed a significant antibacterial activity against <i>Escherichia coli</i> and <i>Staphylococcus aureus.</i> Vanillin diacrylate-based polymer films also demonstrated an antifungal activity in direct contact with <i>Aspergillus niger</i> and <i>Aspergillus terreus.</i> Vanillin diacrylate-based dual curing systems were selected as the most promising for optical 3D printing of bio-based polymers with antibacterial and antifungal activity.
Channels, Propagation and Antennas for Mobile Communications (2003)

This exceptional book introduces the reader to the principles, theory and applications of physical layer wireless/mobile communications. applicators and millimetric antennas. The book emphasises the basic principles needed to establish an understanding of this technology, whilst treating the tools required - such as the mathematics and statistics - in the manner of a practical handbook, thus avoiding detailed derivations.
Autophagy and the Bone Marrow Microenvironment: A Review of Protective Factors in the Development and Maintenance of Multiple Myeloma (2022)

The role of the unfolded protein response (UPR) in plasma cells (PC) and their malignant multiple myeloma (MM) counterparts is a well described area of research. The importance of autophagy in these cells, as well as the interplay between autophagy and the UPR system, has also been well studied. In this review, we will discuss the relationship between these two cellular responses and how they can be utilized in MM to account for the high levels of monoclonal immunoglobulin (Ig) protein synthesis that is characteristic of this disease. Interactions between MM cells and the bone marrow (BM) microenvironment and how MM cells utilize the UPR/autophagy pathway for their survival. These interacting pathways form the foundation for the mechanism of action for bortezomib, a proteasome inhibitor used to modify the progression of MM, and the eventual drug resistance that MM cells develop. One important resistance pathway implicated in MM progression is caspase 10 which attenuates autophagy to maintain its prosurvival function and avoid cell death. We lay a groundwork for future research including 3D <i>in vitro</i> models for better disease monitoring and personalized treatment. We also highlight pathways involved in MM cell survival and drug resistance that could be used as new targets for effective treatment.
A Novel Biodegradable System Based on BSA/PCL Core-shell Structured Nanofibers for Controlled Drug Delivery (2006)

2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings
[Preliminary evaluation on the transmission potential of visceral leishmaniasis after earthquake in Wenchuan]. (2008)

Data of visceral leishmaniasis cases since 2005 were collected through the National Infectious Disease Monitoring System. Number of reported cases in 2005, 2006, 2007 and January to June in 2008 was 59, 49, 77 and 30 in Sichuan Province, and 92, 106, 162 and 83 respectively in Gansu Province. With an increase of the number of stray dogs and susceptible human population, damage of the medical services including diagnosis and treatment capacity after the earthquake, there might be a strengthened transmission potential and possible spread of the disease.
Growth of semi-insulating InP:Fe in a low pressure hydride VPE system using elemental iron and ferrocene as dopant sources (2003)

The authors have demonstrated the suitability of the low-pressure hydride VPE (vapor-phase epitaxy) process for the growth of semi-insulating InP:Fe using two different iron sources. The elemental iron source that is commonly used in hydride VPE systems offers the advantage of a simple and cost-efficient setup due to its similarity to the indium source. It allows the incorporation of iron at very high concentrations, above 10/sup 19/ cm/sup -3/. To achieve a uniform vertical iron distribution of the incorporated iron, special care must be taken when performing the growth. The organic ferrocene source also allows the iron doping of InP at doping levels up to 10/sup 18/ cm/sup -3/. In contrast to the elemental iron source a kinetically limited Fe incorporation is found. A high vertical uniformity of the Fe incorporation can be obtained easily. By using both iron sources, high specific resistivities in the 10/sup 8/-10/sup 9/- Omega -cm region can be achieved.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Objects in concurrent logic programming languages (1986)

article Free Access Share on Objects in concurrent logic programming languages Authors: Kenneth Kahn Knowledge Systems Area, Intelligent System Laboratory, Xerox Palo Alto Research Center Knowledge Systems Area, Intelligent System Laboratory, Xerox Palo Alto Research CenterView Profile , Eric Dean Tribble Knowledge Systems Area, Intelligent System Laboratory, Xerox Palo Alto Research Center Knowledge Systems Area, Intelligent System Laboratory, Xerox Palo Alto Research CenterView Profile , Mark S. Miller Knowledge Systems Area, Intelligent System Laboratory, Xerox Palo Alto Research Center Knowledge Systems Area, Intelligent System Laboratory, Xerox Palo Alto Research CenterView Profile , Daniel G. Bobrow Knowledge Systems Area, Intelligent System Laboratory, Xerox Palo Alto Research Center Knowledge Systems Area, Intelligent System Laboratory, Xerox Palo Alto Research CenterView Profile Authors Info & Claims ACM SIGPLAN NoticesVolume 21Issue 10Oct. 1986 pp 29–38https://doi.org/10.1145/323648.323739Online:01 June 1986Publication History 5citation224DownloadsMetricsTotal Citations5Total Downloads224Last 12 Months8Last 6 weeks7 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Wide bandgap composite EBG substrates (2003)

High-K ceramics are embedded into a polymer host to create an electromagnetic bandgap (EBG) substrate that possess superior properties to previous bandgap implementations in terms of stopband width, attenuation per layer, and practicality. Ceramics are periodically spaced in a commercially-available, Teflon-based host to create a bandgap that spans from 12.1 to 24.1 GHz. Miniature dielectric rods were created in a separate extrusion process, and then placed in a square lattice in a substrate to create the periodic composite. As an application of the material, a defect resonator was created at 20.41 GHz and a Q of 760 was measured.
Different Dose-Dependent Modes of Action of C-Type Natriuretic Peptide on Pseudomonas aeruginosa Biofilm Formation (2018)

We have previously shown that the C-type Natriuretic Peptide (CNP), a peptide produced by lungs, is able to impact Pseudomonas aeruginosa physiology. In the present work, the effect of CNP at different concentrations on P. aeruginosa biofilm formation was studied and the mechanisms of action of this human hormone on P. aeruginosa were deciphered. CNP was shown to inhibit dynamic biofilm formation in a dose-dependent manner without affecting the bacterial growth at any tested concentrations. The most effective concentrations were 1 and 0.1 µM. At 0.1 µM, the biofilm formation inhibition was fully dependent on the CNP sensor protein AmiC, whereas it was only partially AmiC-dependent at 1 µM, revealing the existence of a second AmiC-independent mode of action of CNP on P. aeruginosa. At 1 µM, CNP reduced both P. aeruginosa adhesion on glass and di-rhamnolipid production and also increased the bacterial membrane fluidity. The various effects of CNP at 1 µM and 0.1 µM on P. aeruginosa shown here should have major consequences to design drugs for biofilm treatment or prevention.
Clinical Outcomes of Stereotactic Body Radiotherapy for Patients With Stage I Small-Cell Lung Cancer: Analysis of a Subset of the Japanese Radiological Society Multi-Institutional SBRT Study Group Database (2018)

Stereotactic body radiotherapy (SBRT) is widely used as a curative treatment option for stage I non-small-cell lung cancer, but for patients with stage I small-cell lung cancer, the role of stereotactic body radiotherapy is unclear. In this study, we retrospectively analyzed the outcomes of a subset of patients with stage I small-cell lung cancer treated with stereotactic body radiotherapy in the database of the Japanese Radiological Society-Multi-Institutional stereotactic body radiotherapy Study Group. The 43 patients treated with stereotactic body radiotherapy for stage I small-cell lung cancer between 2004 and 2012 at 11 Japanese institutions were studied: median age = 77 years; 32 (74%) males and 11 females; and 80% were medically inoperable. The clinical stage was IA in 31 and IB in 12. In all patients, the lung tumors were pathologically proven as small-cell lung cancer. A total dose of 48 to 60 Gy was administered in 4 to 8 fractions. The median biologically effective dose (α/β = 10 Gy) was 105.6 Gy. Chemotherapy and prophylactic cranial irradiation were administered in only 8 patients, respectively. The median follow-up time was 23.2 months. The 2-year overall survival, progression-free survival, and distant metastasis-free survival rates were 72.3%, 44.6%, and 47.2%, respectively. The 2-year local control was 80.2%. Regarding the patterns of failure, distant metastasis, lymph node metastasis, and local recurrence were observed in 47%, 28%, and 16% of patients, respectively. No ≥grade 3 stereotactic body radiotherapy-related toxicities were observed. Although stereotactic body radiotherapy was thus revealed to be effective for the local control of stage I small-cell lung cancer, the incidence of distant metastases was high. Further investigations of larger cohorts are needed, including analyses of the effects of combined chemotherapy.
Structural and mechanical properties of chromium nitride, molybdenum nitride, and tungsten nitride thin films (2003)

Cr–N, Mo–N, and W–N thin films are deposited on silicon by rf reactive magnetron sputtering. The crystallographic phase and residual stress are determined by x-ray diffraction analysis. In each of the three material systems, a hexagonal and a face-centred cubic (fcc) phase are observed. Plasma diagnostics using energy-resolved mass spectroscopy reveal that a significant fraction of the Cr+ ions exhibits a high flux and kinetic energy if the nitrogen partial pressure pN2 is low. These high-energy ions effectively bombard the growing film and a densely packed morphology results. In contrast, in absence of a significant amount of high-energy ions at higher pN2, a columnar crystal morphology is observed by scanning electron microscopy. The grain size strongly depends on the presence of a second phase and on the nitrogen content. The hardness, measured by nanoindentation, increases in every material system if the content of the hexagonal phase increases. Under overstoichiometric conditions, the hardness of fcc compounds decreases. The observed hardness differences are explained by morphological changes and by differences in the electronic structure of the compounds.
Isolation and characterization of the human Gs alpha gene. (1988)

The gene for Gs alpha (the alpha subunit of the guanine nucleotide-binding protein Gs) was isolated from human genomic libraries using rat Gs alpha cDNA as a probe. Comparison of the nucleotide sequence of the human gene with that of the rat cDNA revealed that the human Gs alpha gene spans approximately equal to 20 kilobases and is composed of 13 exons and 12 introns. Genomic Southern blot analysis suggests that the human haploid genome contains a single Gs alpha gene. Previous reports indicated the presence of multiple species of Gs alpha cDNA. The structure of the human Gs alpha gene suggests that four types of Gs alpha mRNAs may be generated from a single Gs alpha gene by alternate use of exon 3 and/or of two 3' splice sites of intron 3, where an unusual splice junction sequence (TG) instead of the consensus (AG) is used. S1 nuclease mapping analysis of human Gs alpha mRNA identified multiple transcriptional initiation sites. The promoter region of the human Gs alpha gene has extremely high G + C content (85%). It contains 4 "GC" boxes, but no typical "TATA" or "CAAT" box sequence. In the 5' flanking region, there are several blocks of sequences that are similar to the sequences of the 5' flanking region of the human c-Ki-ras2 gene.
Influence of soil fertilization with composted organic amendments on resistance dissem-ination in crop production (2019)

The selection pressure related to the overuse of antibiotics in human and veterinary medicines is responsi-ble for the increasing of antibiotic resistance, but the environment also plays a role in the resistance dis-semination. In Guadeloupe, a French overseas department, organic amendments resulting from human and animal wastes are widely used in soils fertilization. The objectives of this project were (i) to evaluate the impact of organic amendments on the selection and the diffusion of antibiotic resistant bacteria (ARBs) and antibiotic resistance genes (ARGs) in soils and crop production.
The study was carried out over three vegetable crops sessions (cucumbers and sweet potatoes) on amend-ed or non-amended plots. Two hundred and seven samples, including intrants, biosolids, soils and vege-tables, were collected between March 2015 and February 2017. Samples were cultured on media with or without antibiotics. ARBs identification (isolation, count, antimicrobial testing, MALDI-TOF mass spec-trometry), and ARGs molecular characterization: extended spectrum β-lactamase (ESBL), cephalospori-nase (CASE) coding genes, sulphonamid and quinolone plasmidic resistances were performed.
Our results showed that enterobacteria concentrations were higher in poultry droppings than in horse fe-ces or sewage sludge. Resistant enterobacteria were also more frequent in poultry droppings. After com-posting, the concentration of enterobacteria drastically decreased and resistant enterobacteria were only detected in one compost sample. Resistant enterobacteria were beneath our detection limit in soil and vegetable samples. Concerning the resistance genes, ESBL were more frequent in E. coli isolated from poultry droppings but resistance to sulfonamide was more frequent in horse feces. ESBL genes detected were different in poultry droppings (CTX-M1 mainly) and in horses feces (mainly SHV-12).
Our study confirms the efficiency of composting process to decrease the number of enterobacteria and to reduce the risk of antibiotic resistance diffusion in soils and vegetables. Our study also suggests that ARGs, conferring ESBL phenotype, are biotope specific and that the exchange of genes between bio-topes may not be so easy.
Degradation Processes in Nickel-YSZ-Cermet Anodes for Solid Oxide Fuel Cells (1998)

To investigate the long term stability of Ni-YSZ-cermet anodes for Solid Oxide Fuel Cells (SOFC), various SOFC single cells were operated under realistic working conditions for 700-1000 h. The dependence of degradation rates on current density and water partial pressure, i.e. fuel utilization at the anode side, were determined. The microstructure of the anodes before and after operation was analyzed by electron microscopy. To obtain information about the nickel distribution within the anodes EDX analysis was carried out. These investigations showed that agglomeration of Ni particles was the main cause of the degradation and indicated the limits of current density and fuel utilization within which a degradation of the anode may be tolerated.
Designing a Polymer Blend with Phase Separation Tunable by Visible Light for Computer‐Assisted Irradiation Experiments (2006)

Abstract Summary: A mixture of poly(vinyl methyl ether) (PVME) and a polystyrene derivative bearing cinnamate groups (PSC) was chemically designed so that its phase separation can be tunable by visible light for computer‐assisted irradiation (CAI) experiments. This PSC/PVME blend exhibits a lower critical solution temperature (LCST) and undergoes phase separation upon irradiation with 405 nm visible light. The phase separation was induced by photodimerization of the cinnamate moieties in the presence of 5‐nitroacenaphthene used as a photosensitizer. It was found that for visible light with high intensity, phase separation process was almost frozen by photodimerization of the cinnamate groups which act as a photo‐cross‐linker for the PSC component. It is demonstrated in this work that by using this PSC/PVME blend, phase separation restricted to the micrometer scales can be induced and manipulated by irradiation using a computer‐controlled digital projector. These preliminary results open a new route for spatio‐temporal manipulation of phase separation in photo‐reactive polymer blends. Computer‐assisted irradiation method for a polymer blend with phase separation drivable by visible light. magnified image Computer‐assisted irradiation method for a polymer blend with phase separation drivable by visible light.
Intravenous Immunglobulin Binds Beta Amyloid and Modifies Its Aggregation, Neurotoxicity and Microglial Phagocytosis In Vitro (2013)

Intravenous Immunoglobulin (IVIG) has been proposed as a potential therapeutic for Alzheimer's disease (AD) and its efficacy is currently being tested in mild-to-moderate AD. Earlier studies reported the presence of anti-amyloid beta (Aβ) antibodies in IVIG. These observations led to clinical studies investigating the potential role of IVIG as a therapeutic agent in AD. Also, IVIG is known to mediate beneficial effects in chronic inflammatory and autoimmune conditions by interfering with various pathological processes. Therefore, we investigated the effects of IVIG and purified polyclonal Aβ-specific antibodies (pAbs-Aβ) on aggregation, toxicity and phagocytosis of Aβ in vitro, thus elucidating some of the potential mechanisms of action of IVIG in AD patients. We report that both IVIG and pAbs-Aβ specifically bound to Aβ and inhibited its aggregation in a dose-dependent manner as measured by Thioflavin T assay. Additionally, IVIG and the purified pAbs-Aβ inhibited Aβ-induced neurotoxicity in the SH-SY5Y human neuroblastoma cell line and prevented Aβ binding to rat primary cortical neurons. Interestingly, IVIG and pAbs-Aβ also increased the number of phagocytosing cells as well as the amount of phagocytosed fibrillar Aβ by BV-2 microglia. Phagocytosis of Aβ depended on receptor-mediated endocytosis and was accompanied by upregulation of CD11b expression. Importantly, we could also show that Privigen dose-dependently reversed Aβ-mediated LTP inhibition in mouse hippocampal slices. Therefore, our in vitro results suggest that IVIG may have an impact on different processes involved in AD pathogenesis, thereby promoting further understanding of the effects of IVIG observed in clinical studies.
Supplementary Figure S1 from Highly Potent, Anthracycline-based Antibody–Drug Conjugates Generated by Enzymatic, Site-specific Conjugation (2023)

&lt;p&gt;Effect of IgG pre-treatment on the in vivo half-life of ADCs in immunodeficient mice.&lt;/p&gt;
Control reconfiguration with actuator rate saturation (2005)

Online system identification and online optimization is used to maximize aircraft tracking performance before and after control surface failure, yet prevent departure. The online optimization consists of receding horizon/model predictive optimal control with one-step-ahead actuator rate constraint enforcement. Such hard constraint enforcement is rigorous through use of a linear programming algorithm to include rate saturation in the design.
Robust hybrid pitch detector (1993)

A hybrid pitch detector characterised by parallel analysis of the speech signal in temporal, spectral and cepstral domains is proposed. The voiced/unvoiced decision and pitch period evaluation is realised by a logical analysis of the results from three domains. The experimental analysis shows the robustness of the detector for noisy and telephone speech.