gebhart/patrepeval huggingface dataset:
Calendering of coated paper and board in an extended soft nip (1997)

Abstract Several coated paper products were calendered at different line loads with an extended soft nip, a conventional soft (polymer/steel) nip and a hard (steel/steel) nip. The central roll of the calender was heated to different temperatures; 140, 180 and 210 o C with the extended soft nip, 140 o C with the conventional soft nip and 140 and 180 "C with the hard nip. Calendering with the extended soft nip resulted in general in a paper product with a more uniform structure than that obtained when the other two types of nips were used. This was reflected in lower gloss variations of the coated surface and in a lower variance in the reflectance of paper samples subjected to a bum-out treatment. The latter may be interpreted in terms of a more uniform pore structure in the coating layer. Offset prints on a coated woodfree paper chiendered with the extended soft nip were less mottled than prints on the same paper calendered with the conventional soft nip. There was apparently a correlation between the variance in the bum-out reflectance of the paper samples and the mottle in the offset print. The effect of the extended soft nip on gloss, print gloss, surface roughness and bending stiffness is also reported.
Micromachined probes for on-wafer measurement of millimeter- and submillimeter-wave devices and components (2013)

Terahertz components and devices are typically interfaced with measurement instrumentation and characterized using fixtures equipped with waveguide flanges. Because such fixtures are known to introduce significant uncertainty and error in measurement, it is preferable to characterize such devices in-situ, where the device under test can be measured on-wafer, prior to dicing and separately from the circuit housing to which it is ultimately affixed. This is common practice in the RF and millimeter-wave region using probe stations equipped with coplanar launchers. Commercial coplanar waveguide probes have generally been available to the WR-2.2 band (325-500 GHz) but few options currently exist for on-wafer measurements above these frequencies. This paper describes recent work at the University of Virginia and Dominion Microprobes, Inc. to extend on-wafer measurement capabilities to terahertz frequencies through the design and implementation of coplanar probes based on silicon micromachining. At present micromachined on-wafer probes operating to WR1.2 (600 to 900 GHz) have been demonstrated and exhibit typical insertion losses lower than 7 dB with return loss of 15 dB or greater over a full waveguide band.
Aggregation Tendency of Particulate Fillers: Determination and Consequences (1998)

The agglomeration tendency of 11 commercial CaCO 3 fillers with different particle size and specific surface area was investigated with various techniques. Some powder characteristics were measured and also the sedimentation of treated, as well as non-treated fillers were determined in water and toluene. PP composites containing 25 vol% filler were homogenized in an internal mixer. Melting and crystallization, as well as tensile properties were determined on compression moulded plates. Unambiguous determination of aggregation is difficult, since it depends on interaction and experimental conditions. The extent of aggregation is always determined by the relative magnitude of attractive and separating forces under the given sample preparation and/or testing conditions. Observable aggregation begins at 5–7 m 2 /g specific surface area for the studied fillers, but its extent depends also on their particle size distribution and on surface treatment. Composites with a larger number of aggregates possess inferior mechanical properties, however, the effect depends very much on the characteristics measured.
Musculoskeletal soft-tissue aging : impact on mobility (1993)

This work on the changes that occur with the ageing of soft tissue contains the results of experimental work that holds the promise of producing better musculoskeletal function in older people. It also includes clinically relevant information on improving strength and mobility.
Three-dimensional morphological response of lipid-rich coronary plaques to statin therapy (2016)

High-intensity statin therapy more effectively stabilized fibrous caps at follow-up. The new 3D algorithm provided more comprehensive and detailed information on the changes in plaque phenotype in response to statin therapy.
The Nucleosome Remodeling and Deacetylase complex has an asymmetric, dynamic, and modular architecture (2020)

ABSTRACT The Nucleosome Remodeling and Deacetylase (NuRD) complex is essential for development in complex animals but has been refractory to biochemical analysis. We present the first integrated analysis of the architecture of the native mammalian NuRD complex, combining quantitative mass spectrometry, covalent cross-linking, protein biochemistry and electron microscopy. NuRD is built around a 2:2:4 pseudo-symmetric deacetylase module comprising MTA, HDAC and RBBP subunits. This module interacts asymmetrically with a remodeling module comprising one copy each of MBD, GATAD2 and CHD subunits. The previously enigmatic GATAD2 controls the asymmetry of the complex and directly recruits the ATP-dependent CHD remodeler. Unexpectedly, the MTA-MBD interaction acts as a point of functional switching. The transcriptional regulator PWWP2A modulates NuRD assembly by competing directly with MBD for binding to the MTA-HDAC-RBBP subcomplex, forming a ‘moonlighting’ PWWP2A-MTA-HDAC-RBBP complex that likely directs deacetylase activity to PWWP2A target sites. Taken together, our data describe the overall architecture of the intact NuRD complex and reveal aspects of its structural dynamics and functional plasticity.
Kinect-ed Piano (2015)

The authors describe a gesturally controlled improvisation system for an experimental pianist, developed over several laboratory sessions and used during a performance at the 2011 conference on New Interfaces for Musical Expression (NIME). They discuss the architecture and performative advantages and limitations of the system, and reflect on the lessons learned throughout its development.
Time-varying serum uric acid predicts new-onset atrial fibrillation in treated hypertensive patients. The LIFE Study (2022)

Aim: The Losartan Intervention For Endpoint reduction in hypertension (LIFE) Study showed less new-onset atrial fibrillation (AF) in hypertensive patients receiving losartan- vs. atenolol-based treatment. Because losartan reduces serum uric acid (SUA) levels, the aim of the present study was to investigate relations of SUA with new-onset AF in the study. Methods: Hypertensive patients with electrocardiographic (ECG) left ventricular hypertrophy (LVH) and no prior AF (n = 8,243) were treated for 5.0 ± 0.4 years with losartan- or atenolol-based therapy. Associations of SUA with new-onset AF documented by Minnesota coding were assessed by Cox models using SUA and systolic blood pressure as time-varying covariates to take into account changes of SUA related to losartan or diuretic treatment, changes in renal function, and aging. Results: Time-varying SUA was associated with new AF defined by Minnesota code [hazard ratio (HR) = 1.19 per 16.8 μmol/L (1 mg/dL), (95% confidence intervals (CIs), 1.12–1.26), P &lt; 0.0001], independent of losartan treatment [HR = 0.75 (95% CIs, 0.61–0.93), P = 0.007], older age [HR = 1.95 per 7.0 years (95% CIs, 1.73–2.20), P &lt; 0.0001], male sex [HR = 1.46 (95% CIs, 1.09–1.94), P = 0.010] and higher Cornell voltage-duration product [HR = 1.10 per 1,023 ms·mm (95% CIs, 1.01–1.21), P = 0.034]. Similar results were obtained in Cox models with SUA levels partitioned according to baseline quartiles and in which AF was defined by physician reports or by both Minnesota coding and physician reports. Conclusions: In-treatment SUA is a strong predictor for new-onset AF in hypertensive patients, independent of effects of antihypertensive treatment, age, sex, and ECG-LVH. Further research is needed to clarify how uric acid may provoke AF (ClinicalTrials.gov identifier: NCT00338260).
Prognostic Significance of a Systemic Inflammatory Response in Patients Undergoing Multimodality Therapy for Advanced Colorectal Cancer (2012)

The mGPS is an independent prognostic indicator of survival in patients undergoing multimodality therapy for advanced CRC, if recorded at a relevant time point.
S696 Efficacy of Ustekinumab for Ulcerative Colitis in Patients Through 3 Years: UNIFI Long-term Extension (2021)

Introduction: Ustekinumab (UST), an IL-12/23p40 antagonist, is approved for the treatment of moderate-to-severe ulcerative colitis (UC). The UNIFI long-term extension (LTE) evaluates the ongoing efficacy of UST 90 mg SC maintenance therapy. We report the efficacy data through 3 years of treatment including the subgroups based on biologic treatment history. Methods: During the maintenance phase of UNIFI, 523 intravenous UST induction responders were randomized to SC maintenance therapy (175 SC placebo [PBO]; 172 UST 90mg every 12 weeks [q12w]; 176 UST 90mg q8w). Patients (pts) who completed 44 (wks) of maintenance were eligible for the LTE. 284 UST pts entered the LTE, with pts on PBO discontinued after wk44 unblinding. Pts remained in their treatment allocation initially. Beginning at wk56, randomized pts with worsening UC could adjust to q8w dosing (including sham adjustment if already receiving q8w dosing). Efficacy endpoints included symptomatic remission (Mayo stool frequency subscore of 0 or 1 and a rectal bleeding subscore of 0), biomarkers (CRP and fecal calprotectin), as well as disease-specific quality of life assessed using the Inflammatory Bowel Disease Questionnaire (IBDQ). Results: During the maintenance study, 348 pts were randomized to UST, including 174 bio naïve pts, 161 biologic failure pts, and 13 pts who were biologic-experienced but did not have documentation of biologic failure. Among all pts randomized to UST (intent-to-treat population with nonresponder imputation for missing data and treatment failure criteria), 185 pts (55.2%) were in symptomatic remission at wk152 and 96.4% (185/192) of pts in symptomatic remission at wk152 were corticosteroid-free. Among biologic naïve pts, 115 (66.1%) were in symptomatic remission at wk152 and 97.4% (112/115) of pts in symptomatic remission at wk152 were corticosteroid-free. Among biologic failure pts, 70 (43.5%) were in symptomatic remission at wk152 and 94.3% (66/70) of pts in symptomatic remission at wk152 were corticosteroid-free. Median CRP at wk152 in randomized pts treated with UST in the LTE was 1.5 mg/L. Median fecal calprotectin at wk152 was 151.0 mg/kg. Of the randomized pts treated with UST in the LTE and in IBDQ remission at maintenance baseline, 74.6% were in IBDQ remission at wk140. Conclusion: Symptomatic remission, control of inflammation as measured by CRP and fecal calprotectin levels, and improved quality of life as measured by the IBDQ were observed among pts treated with UST through 3 years.Table 1.: Efficacy results during the LTE in randomized patients.
Carbon nanotube coatings as chemical absorbers (2023)

Airborne or aqueous organic compound collection using carbon nanotubes. Exposure of carbon nanotube-coated disks to controlled atmospheres of chemical warefare (CW)-related compounds provide superior extraction and retention efficiencies compared to commercially available airborne organic compound collectors. For example, the carbon nanotube-coated collectors were four (4) times more efficient toward concentrating dimethylmethyl-phosphonate (DMMP), a CW surrogate, than Carboxen, the optimized carbonized polymer for CW-related vapor collections. In addition to DMMP, the carbon nanotube-coated material possesses high collection efficiencies for the CW-related compounds diisopropylaminoethanol (DIEA), and diisopropylmethylphosphonate (DIMP).
Characterization of Layer-by-Layer Self-Assembled Multilayer Films of Diblock Copolymer Micelles (2007)

The in situ layer-by-layer (LbL) self-assembly of low Tg diblock copolymer micelles onto a flat silica substrate is reported. The copolymers used here were a cationic poly(2-(dimethylamino)ethyl methacrylate)-block-poly(2-(diethylamino)ethyl methacrylate) (50qPDMA-PDEA; 50q refers to a mean degree of quaternization of 50 mol % for the PDMA block) and zwitterionic poly(methacrylic acid)-block-poly(2-(diethylamino)ethyl methacrylate) (PMAA-PDEA), which has anionic character at pH 9. Alternate deposition of micelles formed by these two copolymers onto a silica substrate at pH 9 was examined. The in situ LbL buildup of the copolymer micelle films was monitored using zeta potential measurements, optical reflectometry, and a quartz crystal microbalance with dissipation monitoring (QCM-D). For a six layer deposition, complete charge reversal was observed after the addition of each layer. The OR data indicated clearly an increase in adsorbed mass with each additional micelle layer and suggest that some interdiffusion of copolymer chains between layers and/or an increase in the film roughness, and hence in the effective surface area of the micellar multilayers, must take place as the film is built up. QCM-D data indicated that the self-assembled micellar multilayers on a flat silica substrate undergo structural changes over a prolonged period. This is attributed to longer-term interdiffusion of the copolymer chains between the outer two layers after the initial adsorption of each layer is complete. The QCM-D data further suggest that the outer adsorbed layers adopt a progressively more extended conformation, particularly for the higher numbered layers. The morphology of each successive layer was characterized using in situ soft-contact atomic force microscopy, and micelle-like surface aggregates are clearly observed within each layer of the complex film, suggesting the persistence of aggregate structures throughout the multilayer structure.
Opening of the Blood–Brain Barrier Using Low-Intensity Pulsed Ultrasound Enhances Responses to Immunotherapy in Preclinical Glioma Models (2021)

LIPU increases immune therapeutic delivery to the tumor microenvironment with an associated increase in survival and is an emerging technique for enhancing novel therapies in the brain.
Design, Synthesis, and Characterization of N-Oxide-Containing Heterocycles with in Vivo Sterilizing Antitubercular Activity (2017)

Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), is the infectious disease responsible for the highest number of deaths worldwide. Herein, 22 new N-oxide-containing compounds were synthesized followed by in vitro and in vivo evaluation of their antitubercular potential against Mtb. Compound 8 was found to be the most promising compound, with MIC<sub>90</sub> values of 1.10 and 6.62 μM against active and nonreplicating Mtb, respectively. Additionally, we carried out in vivo experiments to confirm the safety and efficacy of compound 8; the compound was found to be orally bioavailable and highly effective, leading to a reduction of Mtb to undetectable levels in a mouse model of infection. Microarray-based initial studies on the mechanism of action suggest that compound 8 blocks translation. Altogether, these results indicate that benzofuroxan derivative 8 is a promising lead compound for the development of a novel chemical class of antitubercular drugs.
Cascading Retro-Diels–Alder Cycloreversion and Sydnone-Maleimide Based Double 1,3-Dipolar Cycloaddition for Quantitative Thermal Cross-Linking of an Amorphous Polymer Solid (2013)

A new approach to polymer cross-linking is investigated using a cascading cycloreversion of a maleimide-furan adduct and a double 1,3-dipolar cycloaddition between a sydnone and maleimide. The cross-linking proceeds quantitatively above 63 °C, despite the polymer possessing no observable glass transition temperature. The resulting polymer network possesses a high thermal stability (>300 °C) due to the irreversibility of the sydnone-maleimide cycloaddition, which releases CO<sub>2</sub> during the cross-linking, driving the reaction. The rigid three-dimensional structure of the bis-maleimide-sydnone cycloadduct produced local free volumes in films, decreasing the dielectric constant of the material.
<title>Noninvasive and remote detection of cataracts during space exploration with dynamic light scattering</title> (2001)

Outer space is filled with high-energy ionizing radiation. Continuous radiation exposure or slight increase (e.g., due to flares) in it can be hazardous to astronaut health. Therefore cataractogenesis is a possible risk factor. In this paper we apply the sensitive technique of dynamic light scattering to investigate the simulated effects of X-ray exposure to the ocular tissue of non-human animals. An internet web based system integrates photon correlation data and controls the hardware for animal monitoring at a remote site in real time.
Protease activated receptor 4 limits bacterial growth and lung pathology during late stage Streptococcus pneumoniae induced pneumonia in mice (2013)

Streptococcus pneumoniae is a common causative pathogen of pneumonia and sepsis. Pneumonia and sepsis are associated with enhanced activation of coagulation, resulting in the production of several host-derived proteases at the primary site of infection and in the circulation. Serine proteases cleave protease activated receptors (PARs), which form a molecular link between coagulation and inflammation. PAR4 is one of four subtypes of PARs and is widely expressed by multiple cell types in the respiratory tract implicated in pulmonary inflammation, by immune cells and by platelets. In mice, mouse (m)PAR4 is the only thrombin receptor expressed by platelets. We here sought to determine the contribution of mPAR4 to the host response during pneumococcal pneumonia. Pneumonia was induced by intranasal inoculation with S. pneumoniae in mPAR4-deficient (par4-/-) and wild-type mice. Mice were sacrificed after 6, 24 or 48 hours (h). Blood, lungs, liver and spleen were collected for analyses. Ex vivo stimulation assays were performed with S. pneumoniae and mPAR4 activating peptides. At 48 h after infection, higher bacterial loads were found in the lungs and blood of par4-/- mice (p < 0.05), accompanied by higher histopathology scores and increased cytokine levels (p < 0.05) in the lungs. Ex vivo, co-stimulation with mPAR4 activating peptide enhanced the whole blood cytokine response to S. pneumoniae. Thrombin inhibition resulted in decreased cytokine release after S. pneumoniae stimulation in human whole blood. Our findings suggest that mPAR4 contributes to antibacterial defence during murine pneumococcal pneumonia.
Efficient Discovery of Functional and Approximate Dependencies Using Partitions (Extended version) (1997)

Discovery of functional dependencies from relations has been identified as an important database analysis technique. In this paper, we present a new approach for finding functional dependencies from large databases, based on partitioning the set of rows with respect to their attribute values. The use of partitions makes the discovery of approximate functional dependencies easy and efficient, and the erroneous or exceptional rows can be identified easily. Experiments show that the new algorithm is efficient in practice. For benchmark databases the running times are improved by several orders of magnitude over previously published results. The algorithm is also applicable to much larger datasets than the previous methods. Computing Reviews Categories and Subject Descriptors: H.3.1 Content Analysis and Indexing F.2.2 Nonnumerical Algorithms and Problems I.2.6 Learning General Terms: Algorithms, Experimentation Additional Key Words and Phrases: Knowledge Discovery, Data Mining, Func...
Detailed Analysis of the Impact of the Code Doppler on the Acquisition Performance of New GNSS Signals (2014)

International audience
Quantum wells to quantum dots: 640x512 pixels Long-Wavelength Infrared (LWIR) Quantum Dot Infrared Photodetector (QDIP) imaging focal plane array (2006)

We have exploited the artificial atom-like properties of epitaxially grown self-assembled quantum dots (QDs) for the development of high operating temperature long wavelength infrared (LWIR) focal plane arrays (FPAs). QD infrared photodetectors (QDIPs) are expected to outperform quantum well infrared detectors (QWIPs) and are expected to offer significant advantages over II-VI material based FPAs. We have used molecular beam epitaxy (MBE) technology to grow multi-layer LWIR Dot-in-a-Well (DWELL) structures based on the InAs/InGaAs/GaAs material system. This hybrid quantum dot/quantum well device offers additional control in wavelength tuning via control of dot-size and/or quantum well sizes. DWELL QDIPs were also experimentally shown to absorb both 45o and normally incident light. Thus we have employed a reflection grating structure to further enhance the quantum efficiency. The most recent devices exhibit peak responsivity out to 8.1 microns. Peak detectivity of the 8.1 &#956;m devices has reached ~ 1 x 1010 Jones at 77 K. Furthermore, we have fabricated the first long-wavelength 640x512 pixels QDIP imaging FPA. This QDIP FPA has produced excellent infrared imagery with noise equivalent temperature difference of 40 mK at 60K operating temperature.
Sequence-Controlled Radical Polymerization of N-Substituted Maleimides with 1-Methylenebenzocycloalkanes and the Characterization of the Obtained Copolymers with Excellent Thermal Resistance and Transparency (2013)

The radical copolymerization of N-methyl, ethyl, n-butyl, and 2-ethylhexylmaleimides (RMIs) with 1-methylenebenzocycloalkanes (BCms) was carried out to fabricate thermally stable and transparent polymer materials. The copolymerization reactivity of BCms significantly depended on the carbon number of the ring structure of BCms. The analyses of the comonomer–copolymer composition curves and theoretical calculations results revealed that the sequence-controlled copolymerization of RMIs with BCms occurred in alternating and 2:1 fashions according to the BCms reactivity, which depends on the coplanarity of the exomethylene moiety and the benzene ring. The alternating and high-molecular-weight copolymers of BCms and RMIs exhibited excellent thermal and optical properties. We have demonstrated that the radical copolymerization of RMIs is useful not only as the method for high-performance transparent polymer production but also as the tool for the fundamental research of radical polymerization mechanism.
300 GHz transmission system (2008)

A 300 GHz transmission system, designed for terahertz communication channel modelling and propagation studies, is introduced. It consists of an autarkic transmitter and detector units based on Schottky diode mixer technology. The system performance is characterised with regard to link budget and noise. For demonstration, analogue video signals have been transmitted over distances of up to 22 m.