gebhart/patrepeval huggingface dataset:
Association of Oxidative Stress to the Genesis of Anxiety: Implications for Possible Therapeutic Interventions (2014)

Oxidative stress caused by reactive species, including reactive oxygen species, reactive nitrogen species, and unbound, adventitious metal ions (e.g., iron [Fe] and copper [Cu]), is an underlying cause of various neurodegenerative diseases. These reactive species are an inevitable by-product of cellular respiration or other metabolic processes that may cause the oxidation of lipids, nucleic acids, and proteins. Oxidative stress has recently been implicated in depression and anxiety-related disorders. Furthermore, the manifestation of anxiety in numerous psychiatric disorders, such as generalized anxiety disorder, depressive disorder, panic disorder, phobia, obsessive-compulsive disorder, and posttraumatic stress disorder, highlights the importance of studying the underlying biology of these disorders to gain a better understanding of the disease and to identify common biomarkers for these disorders. Most recently, the expression of glutathione reductase 1 and glyoxalase 1, which are genes involved in antioxidative metabolism, were reported to be correlated with anxiety-related phenotypes. This review focuses on direct and indirect evidence of the potential involvement of oxidative stress in the genesis of anxiety and discusses different opinions that exist in this field. Antioxidant therapeutic strategies are also discussed, highlighting the importance of oxidative stress in the etiology, incidence, progression, and prevention of psychiatric disorders.
Selective Diameter Control of Single-Walled Carbon Nanotubes in the Gas-Phase Synthesis (2008)

A novel approach for selective diameter control of single-walled carbon nanotubes (SWNTs) is performed in the gas-phase growth using two kinds of carbon sources with different decomposition properties; the one carbon source (1st carbon source) is the organic solvent which is difficult to decompose in the reactor and the another carbon source (2nd carbon source) is facile to decompose. The diameter distributions of SWNTs synthesized with various conditions of the flow rate of the 2nd carbon source were investigated by resonant Raman scattering, optical absorption, and photoluminescence (PL) mapping measurements. It was found that increasing the flow rate of the ethylene tends to decrease the diameter of synthesized SWNTs, probably due to the earlier nucleation of SWNTs induced by the ethylene addition. The controlling the flow rate of the ethylene used as a 2nd carbon source can selectively tune the diameter distribution of SWNTs in our growth system.
An Adaptive Feedback Method with Channel Change Indication for Band AMC in a Femto Cell (2009)

The band adaptive modulation and coding (band AMC) scheme is used in orthogonal frequency division multiple access (OFDMA) systems to increase mobile communication system throughput, however, an amount of feedback overhead degrades uplink system performance. In this paper, we propose an adaptive feedback method that can significantly reduce the amount of channel feedback information when a femto base station (BS) and mobile stations (MS) communicate in the band AMC mode. Since the channel variation of the MS in the femto cell is relatively small, instead of informing the femto BS of the channel quality information (CQI) periodically, MSs only send CQI feedback to the femto BS when channel condition changes above a threshold. Simulation results show that the proposed scheme can reduce feedback overhead up to 70% without resulting in system throughput degradation compared to the conventional best-M feedback scheme.
Ab Initio and Density Functional Investigation of Reactions of NO with XCO (X = H, F, Cl) (1998)

Ab initio as well as density functional methods are used to investigate various reaction paths for XCO + NO (X = H, F, Cl) with a special focus on the reaction path through the collisional complex CX(O)NO, which is experimentally proposed for X = H and F. It is revealed that the dissociation channels of CH(O)NO to HNO + CO and CF(O)NO to FNO + CO have a higher barrier, while the CCl(O)NO has a dissociation barrier lower than that of the redissociation to reactants. It is expected that this channel should be the major one for the disappearance of CCl(O)NO. To gauge the relative importance of various channels of CX(O)NO disappearance, high-pressure RRKM rate constants are obtained. These results suggest the necessity of reinvestigation of a model based on experiments for the HCO + NO reaction. For the reactions of FCO and ClCO with NO, the MP2 and B3LYP stationary point structures and relative energies are in reasonable agreement with each other, whereas for the HCO + NO reaction, the MP2 level PES is markedly different from the QCISD and B3LYP counterparts.
Optimal multiresolution 3D level-set method for liver segmentation incorporating local curvature constraints (2011)

Advanced liver surgery requires a precise pre-operative planning, where liver segmentation and remnant liver volume are key elements to avoid post-operative liver failure. In that context, level-set algorithms have achieved better results than others, especially with altered liver parenchyma or in cases with previous surgery. In order to improve functional liver parenchyma volume measurements, in this work we propose two strategies to enhance previous level-set algorithms: an optimal multi-resolution strategy with fine details correction and adaptive curvature, as well as an additional semiautomatic step imposing local curvature constraints. Results show more accurate segmentations, especially in elongated structures, detecting internal lesions and avoiding leakages to close structures.
Diagnostic value and dynamic variance of serum antibody in coronavirus disease 2019 (2020)

Viral serological testing is an effective means of diagnosis for SARS-CoV-2 infection. The positive rate and titer variance of IgG are higher than those of IgM in COVID-19.
Manganese-Catalyzed Environmentally Benign Dehydrogenative Coupling of Alcohols and Amines to Form Aldimines and H2: A Catalytic and Mechanistic Study (2016)

The catalytic dehydrogenative coupling of alcohols and amines to form aldimines represents an environmentally benign methodology in organic chemistry. This has been accomplished in recent years mainly with precious-metal-based catalysts. We present the dehydrogenative coupling of alcohols and amines to form imines and H2 that is catalyzed, for the first time, by a complex of the earth-abundant Mn. Detailed mechanistic study was carried out with the aid of NMR spectroscopy, intermediate isolation, and X-ray analysis.
Observation of important current-limiting defects in a recent high pinning force MOCVD IBAD-MgO coated conductor (2011)

Optimization of vortex pinning in REBCO coated conductors has been very successful in recent years, but here we report that strong current-limiting effects can still be present in even highly optimized samples. We studied a state-of-the-art MOCVD IBAD-MgO coated conductor, finding it to have a global pinning force Fpmax(77 K, H ∥ c axis) that reached 11 GN m−3. Using low temperature laser scanning microscopy (LTLSM), we found that the local electric field in the flux-flow state was very inhomogeneous and dominated by a high density of a-axis grains, which obstruct current flow on dimensions of several µm. By carefully cutting narrow tracks without such grains in the path, Fpmax rose to 17 GN m−3, a value exceeding all but a very few, carefully made research films. That today's coated conductors can develop exceptional vortex pinning properties, while still losing a significant fraction of the current density to blocking by growth defects, emphasizes that coated conductor development requires simultaneous attention both to enhancement of vortex pinning and to minimization of current-blocking defects.
Reproductive Characteristics of Cloned Heifers Derived from Adult Somatic Cells1 (2002)

This study examined the onset of puberty, follicular dynamics, reproductive hormone profiles, and ability to maintain pregnancy in cloned heifers produced by somatic cell nuclear transfer. Four adult somatic cell-cloned heifers, derived from a 13-yr-old Holstein cow, were compared to 4 individual age- and weight-matched heifers produced by artificial insemination (AI). From 7 to 9 mo of age, jugular venous blood samples were collected twice weekly, and from 10 to 11 or 12 mo of age, blood sampling was carried out every other day. After the heifers reached puberty (defined as the first of 3 consecutive blood samples with peripheral plasma progesterone concentrations of >1 ng/ml), ultrasound examination of ovaries and jugular plasma sample collection were carried out daily for 1 estrous cycle. Cloned heifers reached puberty later than controls (mean +/- SEM, 314.7 +/- 9.6 vs. 272 +/- 4.4 days and 336.7 +/- 13 vs. 302.8 +/- 4.5 kg for clones and controls, respectively; P < 0.05). However, cloned and control heifers were not different in estrous cycle length, ovulatory follicle diameter, number of follicular waves, or profiles of hormonal changes (LH, FSH, estradiol, and progesterone). Three of the 4 clones and all 4 control heifers became pregnant after AI. These results demonstrate that clones from an aged adult have normal reproductive development.
Eye-Movements During Information Extraction from Administrative Documents (2019)

A key aspect of digital mailroom processes is the extraction of relevant information from administrative documents. More often than not, the extraction process cannot be fully automated, and there is instead an important amount of manual intervention. In this work we study the human process of information extraction from invoice document images. We explore whether the gaze of human annotators during an manual information extraction process could be exploited towards reducing the manual effort and automating the process. To this end, we perform an eye-tracking experiment replicating real-life interfaces for information extraction. Through this pilot study we demonstrate that relevant areas in the document can be identified reliably through automatic fixation classification, and the obtained models generalize well to new subjects. Our findings indicate that it is in principle possible to integrate the human in the document image analysis loop, making use of the scanpath to automate the extraction process or verify extracted information.
Additions and Corrections - Neuroleptic Activity of Chiral trans-Hexahrdro-γ-carbolines. (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAdditions and Corrections - Neuroleptic Activity of Chiral trans-Hexahrdro-γ-carbolines.Reinhard Sarges, Harry Howard, Kathy Donahue, Willard Welch, Beryl Dominy, Albert Weissman, B. Kenneth Koe, and Jon BordnerCite this: J. Med. Chem. 1986, 29, 5, 876Publication Date (Print):May 1, 1986Publication History Published online23 September 2004Published inissue 1 May 1986https://pubs.acs.org/doi/10.1021/jm00155a601https://doi.org/10.1021/jm00155a601research-articleACS PublicationsRequest reuse permissionsArticle Views39Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
ChemInform Abstract: Synthesis and Spectral‐Luminescent Properties of Boron Chelates with Diheterocyclic Amines. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Secure shared continuous query processing (2011)

Data stream management systems (DSMSs) are being used in diverse application domains (e.g., stock trading), however, the need for processing data securely is becoming critical to several stream applications (e.g., patient monitoring). In this paper, we introduce a novel three stage (preprocessing, query processing, and postprocessing) framework to enforce access control in DSMSs. As opposed to existing systems, our framework allows continuous queries to be shared when they have same or different privileges, does not modify the query plans, introduces no new security operators, and checks a tuple only once irrespective of the number of active continuous queries. In addition, it does not affect the DSMS quality of service improvement mechanisms as query plans are not modified. We discuss the prototype implementation using the MavStream Data Stream Management System. Finally, we discuss experimental evaluations to demonstrate the low overhead and feasibility of our approach.
Evaluation Platform of Platoon Control Algorithms in Complex Communication Scenarios (2019)

Cooperative Adaptive Cruise Control (CACC) extends the Adaptive Cruise Control with the additional information<br> exchange between vehicles over vehicle-to-everything (V2X) communications in an ad-hoc network at 5.9 GHz band (ITS-G5)<br> in Europe. Using the beyond-line-of-sight information provided by V2X, the platoon control algorithms realize a shorter safe<br> inter-vehicle distance. Nevertheless, the platoon performance (e.g., the safe inter-vehicle distance) can be easily impacted<br> by the imperfectness of wireless communications. Specifically, in congested traffic scenarios Decentralized Congestion Control<br> algorithms (e.g., Transmit Rate Control (TRC) that regulates message rate based on congestion level) may negatively influence<br> the platoon performance. In this work, we propose an evaluation platform for platoon control algorithms based on industrial V2X<br> nodes operating in the ITS-G5 channels. The real car is simulated by a longitudinal vehicle dynamic model. The model-in-the loop<br> test results demonstrate that the performance of CACC goes down significantly when the message rate is restricted and<br> reduced by TRC. Our evaluation results further conclude that the effect of such complex communication scenarios imposed by<br> the existing standards should be explicitly modelled in the future platoon control algorithms.
Analysis of biofuels production from sugar based on three criteria: Thermodynamics, bioenergetics, and product separation (2010)

We compare the production of four biofuels -- ethanol, butanol, fatty acid ethyl ester (palmitate ethyl ester, PEE), and hydrogen from renewable carbohydrate (glucose) based on the energy-retaining efficiency that is greatly influenced by thermodyanimcs, bioenergetics, and product separation. Ethanol and butanol are produced in anaerobic fermentations; PEE is produced in semi-aerobic fermentation; hydrogen is produced by cell-free synthetic enzymatic pathway biotransformation (SyPaB), where enzymes are produced from carbohydrate by microbial fermentations. A decreasing order in theoretical energy efficiency determined by thermodynamics is hydrogen, ethanol, butanol, and PEE. Bioenergetics analysis suggests that a small fraction of carbohydrate (e.g., 5–15%) is allocated to the synthesis of cell mass in anaerobic fermentations (e.g., ethanol and butanol), a significant fraction (e.g., 20–30% or higher) has to be allocated to the synthesis of cell mass for semi-aerobic fermentations (e.g., PEE production), and a very small fraction (e.g., less than 1%) is used to produce the enzyme mixtures. A decreasing order in product separation energy is hydrogen, secreted PEE, ethanol, butanol, and intracellular PEE. Hydrogen production by SyPaB would be most appealing because its energy-retaining efficiency is ∼49% higher than ethanol, ∼55% higher than butanol, and ∼87% higher than PEE, even without considering higher hydrogen-fuel cell efficiency than those of biofuel-internal combustion engines. Our analysis suggests that it may be difficult to produce some advanced biofuels economically through aerobic fermentations due to low energy efficiency, as compared to ethanol, butanol, and hydrogen.
THE EFFECT OF OVERLOADING AND PREMATURE CENTRIFUGING ON THE POWER OF AN AUTOGENOUS MILL (1997)

Load behaviour in an industrial mill has been measured directly by inserting probes through liner bolts. The data from conductivity probes have indicated the presence of premature centrifuging during manipulation of the load mass. Overloading conditions were also encountered. Overloading and premature centrifuging both reduce the power drawn by the mill. These effects have been successfully modelled.
Ion Pair Supramolecular Structure Identified by ATR‐FTIR Spectroscopy and Simulations in Explicit Solvent** (2021)

The present work uses ATR-FTIR spectroscopy assisted by simulations in explicit solvent and frequency calculations to investigate the supramolecular structure of carboxylate alkali-metal ion pairs in aqueous solutions. ATR-FTIR spectra in the 0.25-4.0 M concentration range displayed cation-specific behaviors, which enabled the measurement of the appearance concentration thresholds of contact ion pairs between 1.9 and 2.6 M depending on the cation. Conformational explorations performed using a non-local optimization method associated to a polarizable force-field (AMOEBA), followed by high quantum chemistry level (RI-B97-D3/dhf-TZVPP) optimizations, mode-dependent scaled harmonic frequency calculations and electron density analyses, were used to identify the main supramolecular structures contributing to the experimental spectra. A thorough analysis enables us to reveal the mechanisms responsible for the spectroscopic sensitivity of the carboxylate group and the respective role played by the cation and the water molecules, highlighting the necessity of combining advanced experimental and theoretical techniques to provide a fair and accurate description of ion pairing.
Error Estimation for Reduced‐Order Models of Dynamical Systems (2007)

The use of reduced‐order models to describe a dynamical system is pervasive in science and engineering. Often these models are used without an estimate of their error or range of validity. In this paper we consider dynamical systems and reduced models built using proper orthogonal decomposition. We show how to compute estimates and bounds for these errors by a combination of small sample statistical condition estimation and error estimation using the adjoint method. Most important, the proposed approach allows the assessment of regions of validity for reduced models, i.e., ranges of perturbations in the original system over which the reduced model is still appropriate. Numerical examples validate our approach: the error norm estimates approximate well the forward error, while the derived bounds are within an order of magnitude.
Regulation of SOCS-1 Expression by Translational Repression (2000)

Accumulating evidence demonstrates that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules termed SOCS (suppressor of cytokine signaling). Previous studies have indicated that the expression of SOCS-related molecules is tightly controlled at the level of transcription. Furthermore, it has been reported that SOCS polypeptides are relatively unstable in cells, unless they are associated with elongins B and C. Herein, we document the existence of a third mechanism of regulation of SOCS function. Our data showed that expression of SOCS-1, a member of the SOCS family, is strongly repressed at the level of translation initiation. Structure-function analyses indicated that this effect is mediated by the 5' untranslated region of socs-1 and that it relates to the presence of two upstream AUGs in this region. Further studies revealed that socs-1 translation is cap-dependent and that it is modulated by eIF4E-binding proteins. In combination, these results uncover a novel level of regulation of SOCS-related molecules. Moreover, coupled with previous findings, they suggest that SOCS expression is tightly regulated through multiple mechanisms, in order to avoid inappropriate interference with cytokine-mediated effects.
Synthetic Inhibitors of Elastase (1994)

For more than two decades investigators around the world, in both academic and industrial institutions, have been developing inhibitors of human neutrophil elastase. A number of very elegant and insightful strategies have been reported. In the case of reversible peptidic inhibitors, this has resulted in the identification of some extremely potent compounds with dissociation constants in the 10(-11) M range. This is quite an accomplishment considering that these low molecular-weight inhibitors are only tri- and tetrapeptides. In the case of the heterocyclic-based inhibitors, the challenge of balancing the heterocycle's inherent reactivity and aqueous stability with the stability of the enzyme-inhibitor adduct has been meet by either using a latent, reactive functionality which is only activated within the enzyme, or by incorporating features which selectively obstruct deacylation but have little effect on the enzyme acylation step. The underlying goal of this research has been the identification of agents to treat diseases associated with HNE. Several animal models have been developed for evaluating the in vivo activity of elastase inhibitors, and compounds have been shown to be effective in all of these models by the intravenous, intratrachael or oral routes of administration. However, only a very small percentage of compounds have possessed all the necessary properties, including lack of toxicity, for progression into the clinic. The peptidyl TFMK ICI 200,880 (25-12) has many of the desired characteristics of a drug to treat the diseases associated with HNE: chemical stability, in vitro and in vivo activity, a long duration of action, and adequate metabolic stability. Currently ICI 200,880 is the only low molecular-weight HNE inhibitor known to be undergoing clinical trials, and may be the compound which finally demonstrates the clinical utility of a synthetic HNE inhibitor.