gebhart/patrepeval huggingface dataset:
Isolation of normal human follicular dendritic cells and CD4‐independent in vitro infection by human immunodeficiency virus (HIV‐1) (1991)

Immunohistological and electron microscopy studies of lymph nodes from patients infected with the human immunodeficiency virus 1 (HIV-1) demonstrated that follicular dendritic cells (FDC), the antigen-presenting cells of the B cell system, contain and may produce the virus. To elucidate the mode of infection of FDC with HIV-1 in vitro we developed an improved method for the preparation of single-cell suspensions of viable FDC with high purity (greater than 90% FDC). These isolated FDC were subjected to human T cell leukemia virus IIIB infection, which was monitored after 4 days in culture using the polymerase chain reaction. We were able to demonstrate that normal human FDC are highly susceptible to infection by HIV-1. Inhibition experiments with the monoclonal antibody OKT4a demonstrate that this infection is independent of the CD4 molecule.
Panning requirement nuggets in stream of software maintenance tickets (2014)

There is an increasing trend to outsource maintenance of large applications and application portfolios of a business to third parties, specialising in application maintenance, who are incented to deliver the best possible maintenance at the lowest cost. To do so, they need to identify repeat problem areas, which cause more maintenance grief, and seek a unified remedy to avoid the costs spent on fixing these individually. These repeat areas, in a sense, represent major, evolving areas of need, or requirements, for the customer. The information about the repeating problem is typically embedded in the unstructured text of multiple tickets, waiting to be found and addressed. Currently, repeat problems are found by manual analysis; effective solutions depend on the collective experience of the team solving them. In this paper, we propose an approach to automatically analyze problem tickets to discover groups of problems being reported in them and provide meaningful, descriptive labels to help interpret these groups. Our approach incorporates a cleansing phase to handle the high level of noise observed in problem tickets and a method to incorporate multiple text clustering techniques and merge their results in a meaningful manner. We provide detailed experiments to quantitatively and qualitatively evaluate our approach
Bulletin épigraphique (2016)

Rousset Denis, Fröhlich Pierre, Hamon Patrice, Sève Michel, Feyel Christophe, Ackermann Delphine, Dubois Laurent, Minon Sophie, Knoepfler Denis, Lhôte Eric, Bouchon Richard Alain, Decourt Jean-Claude, Helly Bruno, Hatzopoulos Miltiade, Avram Alexandre, Aliquot Julien, Feissel Denis, Gatier Pierre-Louis, Kayser François, Dobias-Lalou Catherine. Bulletin épigraphique. In: Revue des Études Grecques, tome 129, fascicule 2, Juillet-décembre 2016. pp. 405-574.
Bandwidth Extension of Spacecraft Attitude Determination via Sensor Fusion (2012)

This paper discusses a bandwidth extension of a spacecraft attitude determination filter. It supposes an offline determination by the ground processing with on-board sensor telemetry data. The bandwidth of the filter is extended via sensor fusion, where an attitude sensor, a low-bandwidth angular rate sensor, and a high-bandwidth angular rate sensor are used. The bandwidth of each sensor is different and each bandwidth involves a common frequency region. A high-bandwidth attitude determination filter is proposed. The angular rate input for the low-bandwidth attitude determination filter is extended to the high frequency range with a complementary fashion. The complementary filter has a flat gain property and a zero phase property. By numerical simulation of three-axis spacecraft attitude vibration, both the bandwidth extension and the accuracy improvement of the attitude determination filter are verified.
Electrochemistry of Hydrogen in the Room Temperature Ionic Liquid 1-Butyl-3-methylimidazolium Bis(trifluoromethylsulfonyl)imide: Dissolved Hydrogen “Lubricates” Diffusional Transport (2011)

We report the electrochemical characterization of bis(trifluoromethylsulfonyl)imide (H[NTf2]) and ferrocene in the room temperature ionic liquid (RTIL) 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ([C2mim][NTf2]) in the presence of dissolved hydrogen (H2). Chronoamperometric measurements in the presence of varying levels of H2 were used to determine the diffusion coefficient of H[NTf2] and ferrocene at 298 K in [C2mim][NTf2]. Upon saturation with H2 at 298 K, these were found to increase from 2.5 (±0.1) × 10–11 m2 s–1 and 4.7 (±0.1) × 10–11 m2 s–1 to 2.8 (±0.1) × 10–11 and 5.1 (±0.1) × 10–11 m2 s–1, respectively. It is believed that the physiochemical changes correspond to the H2 occupying the interstices and therefore resulting in a change in the permittivity of the space between ions of the RTIL, resulting in diminished Coulombic interactions and a net reduction in the RTILs viscosity. Even more significant changes were observed at 308 K, despite the dissolved H2 concentration being lower (4.4 mM H2 at 298 K, 4.0 mM H2 at 308 K). Arrhenius plots of the diffusion coefficient of ferrocene in the RTIL displayed a decrease in the diffusion activation energy from 29.5 kJ mol–1 in the absence of H2 to 20.5 kJ mol–1 upon saturation with H2. The activation energy of diffusion of H2 was also determined in an RTIL for the first time (13.7 kJ mol–1), and deviation of the mass transport of the small H2 molecule from the Stokes–Einstein relationship was confirmed.
Facing the Challenges in the COVID-19 Pandemic Era: From Standard Treatments to the Umbilical Cord-Derived Mesenchymal Stromal Cells as a New Therapeutic Strategy (2023)

Coronavirus disease 2019 (COVID-19), the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which counts more than 650 million cases and more than 6.6 million of deaths worldwide, affects the respiratory system with typical symptoms such as fever, cough, sore throat, acute respiratory distress syndrome (ARDS), and fatigue. Other nonpulmonary manifestations are related with abnormal inflammatory response, the "cytokine storm", that could lead to a multiorgan disease and to death. Evolution of effective vaccines against SARS-CoV-2 provided multiple options to prevent the infection, but the treatment of the severe forms remains difficult to manage. The cytokine storm is usually counteracted with standard medical care and anti-inflammatory drugs, but researchers moved forward their studies on new strategies based on cell therapy approaches. The perinatal tissues, such as placental membranes, amniotic fluid, and umbilical cord derivatives, are enriched in mesenchymal stromal cells (MSCs) that exert a well-known anti-inflammatory role, immune response modulation, and tissue repair. In this review, we focused on umbilical-cord-derived MSCs (UC-MSCs) used in in vitro and in vivo studies in order to evaluate the weakening of the severe symptoms, and on recent clinical trials from different databases, supporting the favorable potential of UC-MSCs as therapeutic strategy.
Joint base stations clustering and feedback bits allocation for multi‐cell coordinated beamforming systems (2017)

In this study, the authors investigate the problem of maximising the mean rate in a multi‐cell coordinated beamforming system considering practical delayed limited feedback and constrained backhaul. To tackle this hard problem, they first derive the analytical expression of the upper bound on the mean rate loss due to the clustered coordination and the imperfect channel feedback. Particularly, this upper bound quantitatively reveals a key tradeoff between decreasing inter‐cell interference with larger base station (BS) cluster and decreasing inter‐user interference with smaller BS cluster but improved channel state information accuracy. In light of this, they jointly optimise the BSs clustering and feedback bits allocation (BCFA) with the objective of minimising the upper bound on mean rate loss, which is equivalent to the problem of maximising the mean rate. Utilising the relaxation‐and‐rounding approach, a BSs clustering and feedback bits allocation algorithm, referred to as BCFA, is designed, which has good performance with low complexity. Finally, extensive simulation results are provided to demonstrate the advantages of the proposed algorithm.
I (2009)

<sc>She waited</sc>, Kate Croy, for her father to come in, but he kept her unconscionably, and there were moments at which she showed herself, in the glass over the mantel, a face positively pale with the irritation that had brought her to the point...
Software antenna and its communication theory for mobile radio communications (2002)

An adaptive array antenna or a smart antenna is named a software antenna because it can be programmable to form a desired beam pattern if an appropriate set of antenna weights is provided in software. It can be a typical tool for realizing a software radio. An adaptive array can be considered as an adaptive filter in the space and time domains for radio communications, so that the communication theory can be generalized from a conventional time domain into both the space and time domains. This paper introduces a spatial and temporal communication theory based on a software antenna, such as spatial and temporal channel modeling, equalization, optimum detection for a single user and multiple users in CDMA, precoding and joint optimization of both the transmitter and receiver. Such spatial and temporal processing promises drastic improvement of performance as a practical countermeasure for multipath fading in mobile radio communications.
The stability of variable step-size LMS algorithms (1999)

Variable step-site LMS (VSLMS) algorithms are a popular approach to adaptive filtering, which can provide improved performance while maintaining the simplicity and robustness of conventional fixed step-size LMS. Here, we examine the stability of VSLMS with uncorrelated stationary Gaussian data. Most VSLMS described in the literature use a data-dependent step-size, where the step-size either depends on the data before the current time (prior step-size rule) or through the current time (posterior step-size rule). It has often been assumed that VSLMS algorithms are stable (in the sense of mean-square bounded weights), provided that the step-size is constrained to lie within the corresponding stability region for the LMS algorithm. For a single tap fitter, we find exact expressions for the stability region of VSLMS over the classes of prior and posterior step-sizes and show that the stability region for prior step size coincides with that of fixed step-size, but the region for posterior step-size is strictly smaller than for fixed step-size. For the multiple tap case, we obtain bounds on the stability regions with similar properties. The approach taken here is a generalization of the classical method of analyzing, the exponential stability of the weight covariance equation for LMS. Although it is not possible to derive a weight covariance equation for general data-dependent VSLMS, the weight variances can be upper bounded by the solution of a linear time-invariant difference equation, after appropriately dealing with certain nonlinear terms. For prior step-size (like fixed step-size), the state matrix is symmetric, whereas for posterior step-size, the symmetry is lost, requiring a more detailed analysis. The results are verified by computer simulations.
(BaxSr1-x)(CoyFe1-y)O3-δ Perovskites as SOFC Cathode Material: Electrode-Electrolyte Reactions and Electrochemical Characterisation (2007)

(BaxSr1-x)(CoyFe1-y)O3-d (BSCF) perovskites are promising SOFC cathode materials. The interfacial reaction with zirconia and ceria electrolyte materials is investigated. The electrochemical performance is studied for y = 0.8, x = 0.25 and 0.5, using im-pedance spectroscopy on dense thin-film microelectrodes, which allows one in particular to determine absolute values of the surface resistance unaffected by morphology effects. Temperature, oxygen partial pressure and applied DC bias are varied to obtain a broad data basis for a further mechanistic analysis.
ChemInform Abstract: Optically Polarized 129Xe in Magnetic Resonance Techniques (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
White blood cell count profiles in anti-aquaporin-4 antibody seropositive neuromyelitis optica spectrum disorder and anti-myelin oligodendrocyte glycoprotein antibody-associated disease (2023)

White blood cell (WBC) count profiles in anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4-NMOSD) and anti-myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) are still unknown. This study evaluated the total WBC count, differential WBC counts, monocyte-to-lymphocyte ratio (MLR), and neutrophil-to-lymphocyte ratio (NLR) in patients with these diseases within three months from an attack before acute treatment or relapse prevention and compared the profiles with those in matched volunteers or in multiple sclerosis (MS) patients. AQP4-NMOSD patients (n = 13) had a higher neutrophil count (p = 0.0247), monocyte count (p = 0.0359), MLR (p = 0.0004), and NLR (p = 0.0037) and lower eosinophil (p = 0.0111) and basophil (p = 0.0283) counts than those of AQP4-NMOSD-matched volunteers (n = 65). Moreover, patients with MOGAD (n = 26) had a higher overall WBC count (p = 0.0001), neutrophil count (p < 0.0001), monocyte count (p = 0.0191), MLR (p = 0.0320), and NLR (p = 0.0002) than those of MOGAD-matched volunteers (n = 130). The three demyelinating diseases showed similar levels of the total and differential WBC counts; however, MOGAD and MS showed different structures in the hierarchical clustering and distributions on a two-dimensional canonical plot using differential WBC counts from the other three groups. WBC count profiles were similar in patients with MOGAD and MS but differed from profiles in matched volunteers or patients with AQP4-NMOSD.
OXIDATIVE STRESS IS NOT RESPONSIBLE FOR PRODUCING THE DEPRESSED ACTIVE HEPATO-CELLULAR FUNCTION DURING EARLY SEPSIS. (1996)

Molnar, R. G.1; Wang, P.2; Ayala, A.2; Jean, P. A.1; Ganey, P. E.1; Roth, R. A.1; Chaudry, I. H.2 Author Information
<b>Interaction of zotepine and chlorprothixene with URAT1-mediated urate transport</b> (2015)

Zotepine and chlorprothixene are antipsychotic drugs, and they have a broad therapeutic effect in patients with schizophrenia. Zotepine and chlorprothixene have been reported to decrease serum urate levels. In addition, an increase in renal clearance of urate was shown in several studies. However, the molecular mechanism underlying these effects has not yet been clarified. In the present study, we measured [14C]urate uptake using stable cells expressing human urate transporter 1 (HEK-hURAT1) and mock cells (HEK-mock) to evaluate the uricosuric actions of zotepine and chlorprothixene. Zotepine and chlorprothixene inhibited URAT1-mediated [14C]urate uptake in a concentration-dependent manner (IC50 values were 14.52μM for zotepine and 6.08μM for chlorprothixene). Next, we measured the activity of xanthine oxidase (XO) to determine whether zotepine and chlorprothixene have inhibitory effects on urate production. Urate production mediated by XO was not inhibited. Taken together, the results suggest that URAT1, a major contributor of renal urate reabsorption and a major target of uricosuric drugs such as losartan and benzbromarone, interacted with zotepine and chlorprothixene; however, XO, a major enzyme in urate production, did not interact with zotepine or chlorprothixene. This is the first study showing that drugs that have the structure of a tricyclic compound interact with URAT1. Elucidation of these interactions may contribute to the development of new anti-hyperuricemic agents by clarifying the structure of the substrate-binding site of URAT1.
The Design of a Single-Chip Multi-Channel Video Decoder (2006)

An analog video decoder is a complicated SOC (system-on-chip) with both analog and digital circuits on it, while a multichannel video decoder will have several decoders integrated on the same chip. In this paper, we talk about the design of a four-channel video decoder. We address the common issues met in the SOC design, and how we handle them in this design. The paper covers different kinds of blocks: analog, phase-locked loop (PLL), digital data-path, and microprocessor etc.
Integrated bioprocess for conversion of gaseous substrates to liquids (2016)

In the quest for inexpensive feedstocks for the cost-effective production of liquid fuels, we have examined gaseous substrates that could be made available at low cost and sufficiently large scale for industrial fuel production. Here we introduce a new bioconversion scheme that effectively converts syngas, generated from gasification of coal, natural gas, or biomass, into lipids that can be used for biodiesel production. We present an integrated conversion method comprising a two-stage system. In the first stage, an anaerobic bioreactor converts mixtures of gases of CO2 and CO or H2 to acetic acid, using the anaerobic acetogen Moorella thermoacetica The acetic acid product is fed as a substrate to a second bioreactor, where it is converted aerobically into lipids by an engineered oleaginous yeast, Yarrowia lipolytica We first describe the process carried out in each reactor and then present an integrated system that produces microbial oil, using synthesis gas as input. The integrated continuous bench-scale reactor system produced 18 g/L of C16-C18 triacylglycerides directly from synthesis gas, with an overall productivity of 0.19 g⋅L(-1)⋅h(-1) and a lipid content of 36%. Although suboptimal relative to the performance of the individual reactor components, the presented integrated system demonstrates the feasibility of substantial net fixation of carbon dioxide and conversion of gaseous feedstocks to lipids for biodiesel production. The system can be further optimized to approach the performance of its individual units so that it can be used for the economical conversion of waste gases from steel mills to valuable liquid fuels for transportation.
Directional virtual carrier sensing for directional antennas in mobile ad hoc networks (2002)

This paper presents a new carrier sensing mechanism called DVCS (Directional Virtual Carrier Sensing) for wireless communication using directional antennas. DVCS does not require specific antenna configurations or external devices. Instead it only needs information on AOA (Angle of Arrival) and antenna gain for each signal from the underlying physical device, both of which are commonly used for the adaptation of antenna pattern. DVCS also supports interoperability of directional and omni-directional antennas. In this study, the performance of DVCS for mobile ad hoc networks is evaluated using simulation with a realistic directional antenna model and the full IP protocol stack. The experimental results showed that compared with omni-directional communication, DVCS improved network capacity by a factor of 3 to 4 for a 100 node ad hoc network.
HIF-1-Dependent Induction of β3 Adrenoceptor: Evidence from the Mouse Retina (2022)

A major player in the homeostatic response to hypoxia is the hypoxia-inducible factor (HIF)-1 that transactivates a number of genes involved in neovessel proliferation in response to low oxygen tension. In the retina, hypoxia overstimulates β-adrenoceptors (β-ARs) which play a key role in the formation of pathogenic blood vessels. Among β-ARs, β3-AR expression is increased in proliferating vessels in concomitance with increased levels of HIF-1α and vascular endothelial growth factor (VEGF). Whether, similarly to VEGF, hypoxia-induced β3-AR upregulation is driven by HIF-1 is still unknown. We used the mouse model of oxygen-induced retinopathy (OIR), an acknowledged model of retinal angiogenesis, to verify the hypothesis of β3-AR transcriptional regulation by HIF-1. Investigation of β3-AR regulation over OIR progression revealed that the expression profile of β3-AR depends on oxygen tension, similar to VEGF. The additional evidence that HIF-1α stabilization decouples β3-AR expression from oxygen levels further indicates that HIF-1 regulates the expression of the β3-AR gene in the retina. Bioinformatics predicted the presence of six HIF-1 binding sites (HBS #1-6) upstream and inside the mouse β3-AR gene. Among these, HBS #1 has been identified as the most suitable HBS for HIF-1 binding. Chromatin immunoprecipitation-qPCR demonstrated an effective binding of HIF-1 to HBS #1 indicating the existence of a physical interaction between HIF-1 and the β3-AR gene. The additional finding that β3-AR gene expression is concomitantly activated indicates the possibility that HIF-1 transactivates the β3-AR gene. Our results are indicative of β3-AR involvement in HIF-1-mediated response to hypoxia.
Aberrations of curved zone plates and Fresnel lenses (1977)

The generalization of zone plates and Fresnel lenses from the usual flat surfaces to curved surfaces is discussed. It is shown that, although Abbe's sine law applies to zone plates but not to Fresnel lenses, both can yield single-element aplanats if formed on a curved surface. Third-order aberration formulas are given.
Quantum nondemolition measurements of single donor spins in semiconductors (2008)

We propose a technique for measuring the state of a single donor-electron spin using a field-effect transistor induced two-dimensional electron gas and electrically detected magnetic-resonance techniques. The scheme is facilitated by hyperfine coupling to the donor nucleus. We analyze the potential sensitivity and outline experimental requirements. Our measurement provides a single-shot, projective, and quantum nondemolition measurement of an electron-encoded qubit state.
An Investigation Into Two Alternative Approaches for the Identification of SFD Bearings for Aeroengine Analysis (2011)

Identification techniques provide a means of efficiently implementing complex nonlinear bearing models in practical turbomachinery applications. This paper considers both identification from an advanced numerical model and identification from experimental tests. Identification from numerical models is essential at the design stage, where rapid simulation of the dynamic performance of a variety of designs is required. Experimental identification is useful to capture effects that are difficult to model (e.g. geometric imperfections, compressibility and its effect on cavitation). With regard to identification from a numerical model, it was shown in a previous paper that the numerical solution of the incompressible Reynolds equation may be replicated using Chebyshev polynomial fits. Tests were performed on a simple rotor-bearing configuration incorporating an advanced numerical bearing model. The identified model was found to be able to match the accuracy of the numerical solution to the Reynolds equation while requiring a fraction of the computation time. In the present work the SFD identification scheme is applied to a realistically-sized representative whole-aeroengine model. It is shown that using recently introduced nonlinear solvers combined with the identified high accuracy bearing models it is possible to run full engine rotor-dynamic simulations, in both the time and frequency domains, at a fraction of the previous computational cost. One major drawback of the Chebyshev technique is that it is not amenable to experimental identification of actual bearings. For this reason, a second identification approach, involving the use of neural networks, is considered in this paper. A test rig that enables empirical identification of SFD forces has been constructed and details of the building and operation of the test rig is presented. The method used to ascertain the training data required by the neural network identification scheme, is also described.