gebhart/patrepeval huggingface dataset:
Familial multiple system tauopathy with presenile dementia: A disease with abundant neuronal and glial tau filaments (1997)

Neurofibrillary lesions made of hyperphosphorylated microtubule-associated protein tau constitute not only one of the defining neuropathological features of Alzheimer disease but also are present in a number of other neurodegenerative diseases with dementia. Here we describe a novel autosomal dominant disease named familial "multiple system tauopathy with presenile dementia," which is characterized by abundant fibrillary deposits of tau protein in both neurons and glial cells. There are no detectable deposits of beta-amyloid. The tau deposits are in the form of twisted filaments that differ in diameter and periodicity from the paired helical filaments of Alzheimer disease. They are stained by both phosphorylation-independent and -dependent anti-tau antibodies. Moreover, tau immunoreactivity coexists with heparan sulfate in affected nerve and glial cells. Tau protein extracted from filaments of familial multiple system tauopathy with presenile dementia shows a minor 72-kDa band and two major bands of 64 and 68 kDa that contain mainly hyperphosphorylated four-repeat tau isoforms of 383 and 412 amino acids.
ChemInform Abstract: Synthesis and Biological Activity of Some D‐Ring Modified Estrone Derivatives. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Embracing and Exploiting Annotator Emotional Subjectivity: An Affective Rater Ensemble Model (2021)

Automated recognition of continuous emotions in audio-visual data is a growing area of study that aids in understanding human-machine interaction. Training such systems presupposes human annotation of the data. The annotation process, however, is laborious and expensive given that several human ratings are required for every data sample to compensate for the subjectivity of emotion perception. As a consequence, labelled data for emotion recognition are rare and the existing corpora are limited when compared to other state-of-the-art deep learning datasets. In this study, we explore different ways in which existing emotion annotations can be utilised more effectively to exploit available labelled information to the fullest. To reach this objective, we exploit individual raters’ opinions by employing an ensemble of rater-specific models, one for each annotator, by that reducing the loss of information which is a byproduct of annotation aggregation; we find that individual models can indeed infer subjective opinions. Furthermore, we explore the fusion of such ensemble predictions using different fusion techniques. Our ensemble model with only two annotators outperforms the regular Arousal baseline on the test set of the MuSe-CaR corpus. While no considerable improvements on valence could be obtained, using all annotators increases the prediction performance of arousal by up to. 07 Concordance Correlation Coefficient absolute improvement on test - solely trained on rate-specific models and fused by an attention-enhanced Long-short Term Memory-Recurrent Neural Network.
The Pivotal Role of Catalysis in France: Selected Examples of Recent Advances and Future Prospects (2017)

The Review describes the most significant results achieved in France in the field of heterogeneous catalysis over the last 10 years and placed in the context of international research. The focus lies on the research conducted in French academic laboratories, often in close collaboration with industrial partners. A wide range of heterogeneous catalysis is covered, including ab initio calculations, biomass conversion, catalytic cracking, catalyst characterization, CO2 conversion, Fischer–Tropsch, pollution abatement, power‐to‐gas and kinetics.
Tracking liver motion using 3-D ultrasound and a surface based statistical shape model (2002)

We present a technique for registering information from preoperative CT or MR images to physical space using intraoperatively acquired 3-D ultrasound data and a surface-based statistical shape model. The model is subject-specific and captures the statistical modes of variation of the liver surface through the breathing cycle. The registration uses a Bayesian formulation, which enables information about the likely position in the breathing cycle to be incorporated in the form of prior knowledge. It is computed using the model and the ultrasound image intensities, and is constrained by the model to produce 'realistic' surfaces. Once an initial registration is computed, the liver motion and deformation can be tracked using a single ultrasound image combined with the statistical model. The technique is demonstrated by registering models constructed for 3 different volunteers to ultrasound data acquired at different points in the breathing cycle. This method has potential application in treatment of any abdominal organ which is affected by breathing motion.
Biotransformation of a Dibenzylbutanolide to Podophyllotoxin Analogues by Shoot Cultures of Haplophyllum patavinum (2003)

A peroxidase from spent medium of shoot cultures from Haplophyllum patavinum (L.) G. Don catalyzes the biotransformation of a synthetic dibenzybutanolide into a podophyllotoxin analogue and a novel compound, derived by the opening of the lactone ring.
A method for the detection of long pseudo-random code DSSS signals based on the processing of delay-multiply (II) - the estimation of the information symbol period and the pseudo-random code sequence (2008)

Aiming at the problems of the detection of the pseudo-random code sequence and the information symbol period of long pseudo-random code DSSS (direct sequence spread spectral) signals, the paper proposes a method based on the processing of delay-multiply. The method does processing of chip-delay-multiply on the received signals at first, then does correlation matrix analysis and gets an estimation sequence of the relative transform sequence of pseudo-random code which is used by the long pseudo-random code DSSS system. The computer simulations show that the proposed method can work well in the context of low signal to noise ratio, by it we can not only retrieve the pseudo-random code sequence of the long pseudo-random code DSSS signals, but also can get an estimation of the information symbol period and the synchronization information of the information symbol.
Supplementary Figure 2 from Protein Phosphatase 2A and Rapamycin Regulate the Nuclear Localization and Activity of the Transcription Factor GLI3 (2023)

Supplementary Figure 2 from Protein Phosphatase 2A and Rapamycin Regulate the Nuclear Localization and Activity of the Transcription Factor GLI3
Atomistic modeling of mechanical properties of polycrystalline graphene (2014)

We performed molecular dynamics (MD) simulations to investigate the mechanical properties of polycrystalline graphene. By constructing molecular models of ultra-fine-grained graphene structures, we studied the effect of different grain sizes of 1-10 nm on the mechanical response of graphene. We found that the elastic modulus and tensile strength of polycrystalline graphene decrease with decreasing grain size. The calculated mechanical proprieties for pristine and polycrystalline graphene sheets are found to be in agreement with experimental results in the literature. Our MD results suggest that the ultra-fine-grained graphene structures can show ultrahigh tensile strength and elastic modulus values that are very close to those of pristine graphene sheets.
Influence of a Functional Core Stability Program on Trunk and Knee Joint Biomechanics in Female Athletes During Lateral Movements (2019)

Mornieux, G, Weltin, E, Friedman, C, Pauls, M, Forsythe, S, and Gollhofer, A. Influence of a functional core stability program on trunk and knee joint biomechanics in female athletes during lateral movements. J Strength Cond Res 35(10): 2713-2719, 2021-Trunk positioning has been shown to be associated with knee joint loading during athletic tasks, especially changes of direction. Quasistatic and conventional core stability (CS) training did not improve the biomechanics of cutting maneuvers according to reports in the literature. The purpose of this study was to test whether a 5-week dynamic and functional CS training program would improve trunk positioning and knee joint control during lateral movements. Nineteen female athletes participated in a longitudinal study, where lateral reactive jumps (LRJs) and unanticipated cuttings were performed before and after CS training (15 training sessions within 5 weeks) while 3D kinematics and kinetics were measured. In addition, core endurance and power were evaluated. Core stability training increased trunk rotation in the new movement direction (p = 0.02) during LRJ. However, lateral trunk lean was significantly increased during LRJ (from 5.6 to 7°) and cuttings (from 3.8 to 5.8°) after CS training. Knee joint abduction moment was not influenced. Finally, core endurance (p < 0.01) and core power (p < 0.001) were significantly improved after CS training. A 5-week dynamic and functional CS training program improved core muscle endurance and power. This might explain the better trunk rotation toward the new movement direction during LRJ; however, it was not effective during unanticipated cuttings. The practical application of this research will allow strength and conditioning professionals to setup training programs with simple and relevant exercises to increase the core endurance and power of trained individuals.
Supplementary Data from Identification of CD44 as a Surface Biomarker for Drug Resistance by Surface Proteome Signature Technology (2023)

&lt;p&gt;Supplementary Figures S1-S3; Supplementary Methods.&lt;/p&gt;
Immunocytochemical studies on co-localization of -granule membrane IIb 3 integrin and intragranular fibrinogen of human platelets and their cell-surface expression during the thrombin-induced release reaction (2003)

We employed a double-staining method to immunocytochemically study the role of alpha-granule membrane alphaIIbbeta3 integrin in the expression of intragranular fibrinogen (Fbg) and albumin on the surface of thrombin-activated human platelets. In unstimulated platelets, alphaIIbbeta3 was distributed along the alpha-granule membrane as well as on the cell-surface membrane, including the open canalicular system (OCS), while Fbg and albumin were exclusively and evenly detected in the granules. At 30 s after activation by 0.1 U ml(-1) thrombin under non-stirred conditions, a small amount of Fbg in the granules was redistributed in association with alpha-granule membrane alphaIIbbeta3, suggesting that co-localization between alphaIIbbeta3and Fbg occurs at this period during platelet activation. At 1-5 min, the shape of the platelets changed from discoid to spheroid with pseudopodia and intact alpha-granules were no longer observed in these cells. Fibrinogen associated with alphaIIbbeta3 became increasingly expressed on the membranes of both the swollen OCS and the cell surface. Nevertheless, abundant Fbg still remained in the lumen of the swollen OCS, the membrane of which had already been depleted of alphaIIbbeta3. By western blot analysis using anti-human Fbg antibody, we detected no Fbg in the surrounding medium of the thrombin-stimulated platelets for 5 min. Unlike Fbg, abundant albumin in the alpha-granules was released into the surrounding medium without association with the membrane of either the alpha-granules or the cell surface. These results suggest that a small portion of the intragranular Fbg may bind to an Fbg binding site expressed on the activated aIIbbeta3 on the alpha-granule membrane, resulting in the formation of an alphaIIbbeta3-Fbg complex, which is then moved through the OCS membrane and expressed on the cell-surface membrane. Thus, alpha-granule membrane aIIbbeta3 may act as a carrier of intragranular Fbg.
Involvement of the interferon‐γ–induced T cell–attracting chemokines, interferon‐γ–inducible 10‐kd protein (CXCL10) and monokine induced by interferon‐γ (CXCL9), in the salivary gland lesions of patients with Sjögren's syndrome (2002)

These findings suggest that IFNgamma stimulates the production of IP-10 and Mig in the SS ductal epithelium, and that IP-10 and Mig are involved in the accumulation of T cell infiltrates in the SS salivary gland. Chemokines or chemokine receptors could be a rational new therapeutic target in SS.
A Comparison of Single-Acquisition and Separate-Acquisition Protocols (2002)

18F-FDG is a well-established tracer for evaluating myocardial viability, as is 99mTc-tetrofosmin (TET) for evaluating myocardial perfusion. Dual-isotope single-acquisition (DISA) studies using a 99mTc perfusion agent and 18F-FDG have been performed to evaluate myocardial viability. The purpose of this investigation was to determine whether there is a difference in the results of gated SPECT DISA, compared with gated SPECT DIDA (dualisotope dual-acquisition) studies using 99mTc-TET/18F-FDG and a high-energy collimated dual-head SPECT system. Methods: We prospectively studied 13 patients with depressed left ventricular function using both acquisition protocols. Summed rest scores were calculated for both 99mTc and 18F-FDG studies using a 12-segment model and a 5-grade severity score. Images were evaluated by a single reader who did not know whether the images were acquired separately or simultaneously. Results: The concordance of DISA and DIDA protocols for 99mTc-TET when allowing no difference in the SRS was 57%, or 89 of 156 segments. The concordance of DISA and DIDA protocols for 18F-FDG was 86%, or 134 of 156 segments. The concordance of segments determined to be viable versus nonviable was 92%, or 143 of 156 segments. Ejection fraction measurements obtained by gated 99mTc-TET studies correlated strongly with those obtained by gated 18F-FDG studies. Conclusion: A high concordance for 18F-FDG studies was shown between gated DISA and gated DIDA. A lower concordance was shown between gated DISA and gated DIDA studies using 99mTc-TET, most likely because of downscatter from 18F into the 99mTc window. An excellent concordance was demonstrated between the 2 techniques for viability assessment. The gated 99mTc-TET/18F-FDG DISA protocol can be both a reliable and an efficient way to evaluate myocardial function, perfusion, and viability.
Java table browser: transportation and presentation of large statistical tables over Network (2019)

This study describes a novel design of Java table browser using XML (jTBX). A standard table-browsing environment is provided in the form of Java applet which can be opened in any web browser such as Netscape, or Internet Explore with Java 1.2 plug-in installed. Some manipulation functions to tables are supported for various level of objects in table (table, sub-table, column, row, cell). A hierarchical Java tree provides the table of content (TOC) of available tables. Three tier architecture is used in jTBX system design. Remote database tier provides raw data from distributed sites. Web server tier generates the response in the standard XML format to the requests from the client side tier (table browser). Metadata for tables are integrated into the XML files (or streams) before being used by client Java applet. Multiple threads are generated for a large table transporting.
Avoiding Interruptions - QoE Trade-offs in Block-coded Streaming Media Applications (2010)

We take an analytical approach to study Quality of user Experience (QoE) for video streaming applications. First, we show that random linear network coding applied to blocks of video frames can significantly simplify the packet requests at the network layer and save resources by avoiding duplicate packet reception. Network coding allows us to model the receiver's buffer as a queue with Poisson arrivals and deterministic departures. We consider the probability of interruption in video playback as well as the number of initially buffered packets (initial waiting time) as the QoE metrics. We characterize the optimal trade-off between these metrics by providing upper and lower bounds on the minimum initial buffer size, required to achieve certain level of interruption probability for different regimes of the system parameters. Our bounds are asymptotically tight as the file size goes to infinity.
TIME-OPTIMAL ALGORITHMS FOR GENERALIZED DOMINANCE COMPUTATION AND RELATED PROBLEMS ON MESH CONNECTED COMPUTERS AND MESHES WITH MULTIPLE BROADCASTING (1996)

The generalized dominance computation (GDC) problem is stated as follows: Let A = {a1, a2, …, an} be a set of triplets, i.e., ai = (xi, yi,fi), “⊲” be a linear order relation defined on x-components, “<” be a linear order relation defined on y-components, and “⊕” an abelian operator defined on f-components. It is required to compute for every ai ∊ A, the expression D(ai) = fj1 ⊕ fj2 ⊕ … ⊕ fjk , where { j1,j2, … jk { is the set of all indices j such that aj ∊ A and xj ⊲ xi, yj < yi . First, this paper presents a time-optimal algorithm to solve the GDC problem in O(√n ) on a mesh connected computer of size. √n × √n. To prove the generality of our approach, we show how a number of computational geometry problems, such as ECDF (empirical cumulative distribution function) searching and two-set dominance counting, can be derived from GDC problem. Second, we define a natural extension of the GDC, called mulliple-query generalized dominance computation (MQGDC), on meshes with multiple broadcasting. By using multiple querying (MQ) paradigm of Bokka et al. |3, 4, 6| we devise a time-optimal algorithm that solves a MQGDC problem involving a set A of n items and a set Q of m queries in O (n⅙ ⅓) on a mesh with multiple broadcasting of size √n × √n.
Efficient Clustering and Path Planning Strategies for Robotic Data Collection Using Space-Filling Curves (2016)

In this paper, we consider a scenario where a mobile robot is tasked with periodically collecting data from a fixed wireless-sensor network. Our goal is to minimize the total cost of the system, including the motion cost of the robot and the communication cost of the sensors to the robot in realistic fading environments. We propose a strategy that divides the sensors into a number of clusters and uses a mobile robot to visit each cluster in order to wirelessly collect the corresponding data. We then propose a computationally efficient approach to solve this joint path planning and clustering problem by using space-filling curves. More specifically, by utilizing space-filling curves and their locality property, we show how the coupled clustering, stop position selection, path planning, and motion design problems can be solved as a series of convex optimization problems. We further mathematically characterize an upper bound for the total energy consumption of our proposed approach for the case of uniformly distributed sensors, relating it to key motion and communication parameters, such as motor parameters, channel multipath fading and shadowing variances, path-loss exponent, and target bit error rate. Finally, we verify the effectiveness of our framework in a simulation environment. Our results with realistic channel and motion parameters show considerable energy savings.
Computing Where Perturbations Affect the Acoustic Impulse Response in the Ocean (2018)

We compute accurate maps of oceanic perturbations affecting transient acoustic signals propagating from source to receiver. The technological advance involves coupling the one-way wave equation (OWWE) propagation model with the theory for the Differential Measure of Influence (DMI) yielding the map. The DMI requires two finite-frequency solutions of the acoustic wave equation obeying reciprocity: from source to receiver and vice versa. OWWE satisfies reciprocity at basin-scales with sound speed varying horizontally and vertically. At infinite frequency, maps of the DMI collapse into rays. Mapping the DMI is useful for understanding measurements of acoustic perturbations at finite frequencies.
Spatial ℋ/sub 2/ control of a piezoelectric laminate beam: experimental implementation (2002)

This paper designs and experimentally evaluates the performance of a feedback controller to suppress vibration of a flexible beam. The controller is designed to minimize the spatial /spl Hscr//sub 2/ norm of the closed-loop system to ensure average reduction of vibration throughout the entire structure. Vibrations of the first six bending modes of the beam are controlled using a collocated piezoelectric actuator-sensor pair attached to the beam. Feedthrough terms are incorporated into the flexible-structure model to correct the locations of the in-bandwidth zeros. It is shown that the spatial /spl Hscr//sub 2/ control has an advantage over the pointwise /spl Hscr//sub 2/ control in minimizing the vibration of the entire structure. The spatial /spl Hscr//sub 2/ controller minimizes the /spl Hscr//sub 2/ norm of the entire structure more uniformly, while the pointwise /spl Hscr//sub 2/ controller only has a local effect. The implemented spatial /spl Hscr//sub 2/ controller is able to minimize the first six bending modes of the beam effectively. This spatial /spl Hscr//sub 2/ control can also be applied to more general structural vibration suppression problems.
Genomic classifiers (ColoPrint/MSI-Print) predict outcome and chemotherapy benefit in stage II and III colon cancer patients. (2013)

378 Background: Although the benefit of chemotherapy in stage II and III colon cancer patients is significant, many patients might not need adjuvant chemotherapy because they have a good prognosis even without additional treatment. ColoPrint is a gene expression classifier that distinguish patients with low or high risk of disease relapse. It was developed using whole genome expression data and has been validated in public datasets, independent European patient cohorts and technical studies (Salazar 2011 JCO, Maak 2012 Ann Surg). Methods: In this study, the commercial ColoPrint test was validated in stage II (n=96) and III patients (n=95) treated at the MD Anderson Cancer Center from 2003 to 2009. Frozen tissue specimen, clinical parameters, MSI-status and follow-up data (median follow-up 64 months) were available. The 64-gene MSI-signature developed to identify patients with deficient mismatch repair system (Tian 2012 J Path) was evaluated for its accuracy to identify MSI patients and also for prognosis. Results: In this cohort, ColoPrint classified 56% of stage II and III patients as being at low risk. The 3-year Relapse-Free-Survival (RFS) was 90.6% for Low Risk and 78.4% for High Risk patients with a HR of 2.33 (p=0.025). In uni-and multivariate analysis ColoPrint and stage were the only significant factors to predict outcome. The MSI-signature classified 47 patients (24.6%) as MSI-H and most MSI-H patients were ColoPrint low risk (81%). Patients who were ColoPrint low risk and MSI-H by signature had the best outcome with a 3-year RFS of 95% while patients with ColoPrint high risk had a worse outcome independently of the MSI-status. Low risk ColoPrint patients had a good outcome independent of stage or chemotherapy treatment (90.1% 3-year RFS for treated patients, 91.4% for untreated patients) while ColoPrint high risk patients treated with adjuvant chemotherapy had 3-year RFS of 84%, compared to 70.1% 3-year RFS in untreated patients (p=0.026). Conclusions: The combination of ColoPrint and MSI-Print improves the prognostic accuracy in stage II and stage III patients and may help the identification of patients at higher risk who are more likely to benefit from additional treatment
Reactivity of aminopyrroles: Protonation (1996)

Abstract The behaviour of 2‐ and 3‐aminopyrroles towards protonation is similar. In dimethyl sulphoxide/trifluoroacetic acid they are protonated at the exocyclic nitrogen, whereas in pure trifluoroacetic acid, protonation at the 5‐ and/or 3‐position of the ring takes place.