gebhart/patrepeval huggingface dataset:
Mitochondrial dysfunction in non-alcoholic fatty liver disease and insulin resistance: Cause or consequence? (2013)

Non-alcoholic fatty liver disease (NAFLD) is considered the hepatic manifestation of the metabolic syndrome and refers to a spectrum of disorders ranging from steatosis to steatohepatitis, a disease stage characterized by inflammation, fibrosis, cell death and insulin resistance (IR). Due to its association with obesity and IR the impact of NAFLD is growing worldwide. Consistent with the role of mitochondria in fatty acid (FA) metabolism, impaired mitochondrial function is thought to contribute to NAFLD and IR. Indeed, mitochondrial dysfunction and impaired mitochondrial respiratory chain have been described in patients with non-alcoholic steatohepatitis and skeletal muscle of obese patients. However, recent data have provided evidence that pharmacological and genetic models of mitochondrial impairment with reduced electron transport stimulate insulin sensitivity and protect against diet-induced obesity, hepatosteatosis and IR. These beneficial metabolic effects of impaired mitochondrial oxidative phosphorylation may be related not only to the reduction of reactive oxygen species production that regulate insulin signaling but also to decreased mitochondrial FA overload that generate specific metabolites derived from incomplete FA oxidation (FAO) in the TCA cycle. In line with the Randle cycle, reduced mitochondrial FAO rates may alleviate the repression on glucose metabolism in obesity. In addition, the redox paradox in insulin signaling and the delicate mitochondrial antioxidant balance in steatohepatitis add another level of complexity to the role of mitochondria in NAFLD and IR. Thus, better understanding the role of mitochondria in FA metabolism and glucose homeostasis may provide novel strategies for the treatment of NAFLD and IR.
Fat-Compensated T1 Mapping of Non-Alcoholic Fatty Liver Disease with MPRAGE and MP2RAGE (2023)

Fat is a confounding factor in the use of T 1 measurements as a non-invasive method of assessing non-alcoholic fatty liver disease. A Dixon-based water/fat separation was used to produce T 1 maps based on the separated water signal in MPRAGE and MP2RAGE sequences. A correlation inconsistent with biophysical processes was observed between uncorrected MP2RAGE T 1 values and fibrosis stage, but using the fat compensated T 1 values corrects the correlation. The same effect was seen to a lesser extent with MPRAGE T 1 values. Further investigation and validation with a larger cohort may provide a more reliable biomarker of liver fibrosis within NAFLD.
Performance Benchmarking for Graphene Nanoribbon, Carbon Nanotube, and Cu Interconnects (2008)

Physics-based equivalent circuit models are presented for armchair and zigzag graphene nanoribbons (GNRs), and their conductances have been benchmarked against those of carbon nanotubes and copper wires. Atomically thick GNRs with smooth edges can potentially have smaller resistances compared with copper wires with unity aspect ratios for widths below 8nm and stacks of non-interacting GNRs can have substantially smaller resistivities compared to Cu wires.
Characterization of the virA virulence gene of the nopaline plasmid, pTiC58, of Agrobacterium tumefaciens (1989)

We have determined the complete nucleotide sequence of a 4.8 kilobase fragment encompassing the virA locus of the nopaline-type plasmid, pTiC58, of Agrobacterium tumefaciens. virA is composed of a single open reading frame of 2499 nucleotides, capable of encoding a protein of 91.3 kiloDaltons. A trpE::virA gene fusion was used to confirm the reading frame of virA. High nucleotide and amino acid sequence homologies were observed between pTiC58 virA and the virA sequences of three octopine-type plasmids. Strong homologies in amino acid sequence were observed between pTiC58 VirA and seven bacterial proteins which control various regulons. Two hydrophobic domains within VirA are also consistent with a model in which VirA acts as a membrane-bound sensor of plant signal molecules.
Minority and Majority Charge Carrier Mobility in Cu2ZnSnSe4 revealed by Terahertz Spectroscopy (2018)

The mobilities of electrons and holes determine the applicability of any semiconductor, but their individual measurement remains a major challenge. Here, we show that time-resolved terahertz spectroscopy (TRTS) can distinguish the mobilities of minority and majority charge carriers independently of the doping-type and without electrical contacts. To this end, we combine the well-established determination of the sum of electron and hole mobilities from photo-induced THz absorption spectra with mobility-dependent ambipolar modeling of TRTS transients. The method is demonstrated on a polycrystalline Cu<sub>2</sub>ZnSnSe<sub>4</sub> thin film and reveals a minority (electron) mobility of 128 cm<sup>2</sup>/V-s and a majority (hole) carrier mobility of 7 cm<sup>2</sup>/V-s in the vertical transport direction relevant for light emitting, photovoltaic and solar water splitting devices. Additionally, the TRTS analysis yields an effective bulk carrier lifetime of 4.4 ns, a surface recombination velocity of 6 * 10<sup>4</sup> cm/s and a doping concentration of ca. 10<sup>16</sup> cm<sup>-3</sup>, thus offering the potential for contactless screen novel optoelectronic materials.
MicroRNAs in lipid metabolism (2010)

Recent advances in the understanding of the regulation of lipid metabolism indicate that miRNAs play major roles in regulating cholesterol and fatty acid metabolism. These new findings may open new avenues for the treatment of dyslipidemias.
REVIEWS (1994)

Journal Article REVIEWS Get access The Great Good Place: The Country House and English Literature. BY MALCOLM KELSALL. Pp. xiv+210. Hemel Hempstead: Harvester Wheatsheaf, 1993. £22 50. LESLEY LEWIS LESLEY LEWIS London Search for other works by this author on: Oxford Academic Google Scholar The Review of English Studies, Volume XLV, Issue 180, November 1994, Pages 608–610, https://doi.org/10.1093/res/XLV.180.608 Published: 01 November 1994
Fully parallel 30-MHz, 2.5-Mb CAM (1998)

Translation functions in high-speed communications networks such as Internet protocol and asynchronous transfer mode are requiring larger and faster lookup tables. Content addressable memories (CAMs) provide built-in hardware lookup capability with high speed and high flexibility in address allocation. Previous high-capacity CAMs have been inadequate for emerging applications; comparators are time-shared among multiple bits or multiple words, resulting in serialized operation, Fully parallel architectures represent the best solution for high-speed operation, but previous fully parallel CAMs have lacked the capacity required for leading-edge networking applications. This paper describes a fully parallel (single-clock-cycle) CAM chip. The chip uses a 0.35-/spl mu/m digital CMOS technology to achieve 2.5 Mb of CAM storage and 30-MHz operating frequency. Innovative layout techniques are used to achieve two-dimensional decoding, a traditional problem with high-capacity CAMs. Architecture and operation of the chip are described, including a novel NAND match architecture, operation-specific self-timing loops, and on-board cascade management circuits. The chip functions at 31 MHz, with a search access time of 26 ns and an average search power dissipation of 5.2 W at 25 MHz.
SHORT PERIOD VARIATIONS OF ATMOSPHERIC TEMPERATURE AND ELECTRICAL CONDUCTIVITY IN THE STRATOSPHERE (1973)

Apparently related fluctuations of atmospheric temperature and electric field and current were simultaneously observed at an approximately constant height level of about 28 km in the stratosphere for about 9 hours at night in a large balloon experiment. The periods of the fluctuations range from about 10 minutes to 2 hours. The phase differences between both variations have roughly equal values between 90° and 180° or -90° and -180° regardless of their periods. Using the polarization factors of temperature and conductivity derived from the theory of atmospheric internal gravity waves, the phase differences are calculated taking vertical wavelength as a parameter, and they are shown to be constant at longer periods than about 20 minutes. It is, however, difficult to explain the large values of the phase differences.
PS982 THE ROLE OF STAT3 ISOFORMS IN ACUTE MYELOID LEUKEMIA (2019)

Background: Signal transducer and activator of transcription 3 (STAT3) plays a central role in proliferation, differentiation and oncogenic transformation. It is expressed in two alternatively spliced isoforms, STAT3α and truncated STAT3β, which lacks the C‐terminal transactivation domain and instead carries seven unique amino acids. Interestingly, STAT3β recently gained attention as a powerful anti‐tumorigenic molecule and protective prognostic marker. This has been shown in patients with esophageal squamous cell carcinoma as well as in mouse models for breast, skin and colon cancer. Deregulated STAT3 signaling is frequently observed in leukemogenesis and generally associated with a poor clinical outcome in patients with acute myeloid leukemia (AML). In addition, it has been shown that the expression ratios of STAT3α and STAT3β change upon myeloid differentiation. However, the exact role of STAT3β in AML patients and during disease progression remains unknown. Aims: The goal of our study is to analyze the contribution of the two STAT3 isoforms to leukemogenesis with a particular focus on STAT3β in AML development. Methods: We analyzed more than 50 AML patient samples for STAT3β/STAT3α mRNA expression levels and its correlation with clinical prognosis and overall survival. Furthermore, we generated an inducible Stat3β transgenic mouse model and crossed it with Pten ‐deficient mice, a previously described model for AML. In addition, we used fetal liver‐derived stem cells from Stat3β transgenic mice, transduced with a retrovirus encoding for the MLL‐AF9 translocation, in a transplant model for AML. Results: We observed a correlation between clinical prognosis and STAT3β/STAT3α expression ratio. A higher STAT3β/STAT3α ratio was further associated with a favorable clinical prognosis and a significantly increased overall survival. In both in vivo mouse models we could demonstrate that the expression of STAT3β impairs leukemogenesis and leukemic cell infiltration into hematopoietic organs. The STAT3β‐dependent delay in disease progression and leukemic infiltration resulted in a significant increase of overall survival. Summary/Conclusion: In summary, the results of our study demonstrate STAT3β as an anti‐tumorigenic molecule in AML mouse models and the STAT3β/STAT3α ratio in AML patient derived blasts positively correlates with survival.
ChemInform Abstract: FAVORSKII‐TYPE REARRANGEMENT OF CHLORINATED ACETYLACETONE MONOMETHYL ENOL ETHERS. PRESUMPTIVE EVIDENCE FOR A CYCLOPROPANE DIMETHYL ACETAL INTERMEDIATE (1977)

Abstract Durch Behandlung mit Diazomethan (II) erhält man aus 1,1‐Dichlor‐acetylaceton (I) ‐ zunächst ein Gemisch der vier isomeren Äther (III)‐(VI), das jedoch beim Destil‐ ′ lieren völlig zu den stabileren E‐Isomeren (IV) und (VI) isomerisiert.
New 2-pyridone derivatives via 1,3-dipolar cycloadditions of novel mesoionic compounds (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew 2-pyridone derivatives via 1,3-dipolar cycloadditions of novel mesoionic compoundsD. Roger Moore and Lon J. MathiasCite this: J. Org. Chem. 1987, 52, 8, 1599–1601Publication Date (Print):April 1, 1987Publication History Published online1 May 2002Published inissue 1 April 1987https://pubs.acs.org/doi/10.1021/jo00384a039https://doi.org/10.1021/jo00384a039research-articleACS PublicationsRequest reuse permissionsArticle Views203Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Developments in oriented polymers, 1970–2004 (2004)

AbstractAbstractThe discovery of methods to make highly oriented polymers has given tremendous stimulus to both basic polymer science and industrial developments in the period 1970 to the present. High modulus, high strength fibres for aramids and polyethylene, are based on very different methodologies but the ultimate result is similar in producing fully extended polymer chains. For polymers in solid sections, the enhancement of properties is less dramatic but still very worthwhile. In this case, three methods are described: hydrostatic extrusion, die-drawing and hot compaction of oriented fibres and tapes. Hot compaction is a new technique with many possibilities for which a wide range of applications has already been identified.Keywords: ORIENTED POLYMERSSOLUTION PROCESSINGHYDROSTATIC EXTRUSIONDIE-DRAWINGHOT COMPACTION This article is part of the following collections: Signpost Papers
A new least squares approach to blind beamforming (2002)

We present a new two-step approach to blind beamforming based on the least squares criterion. The first step consists of "whitening" the array received vector, i.e., transforming its response matrix to some unknown unitary matrix. The second step consists of estimating the unitary matrix from the fourth order cumulants by a least squares criterion. In contrast to the corresponding "joint diagonalization" step of the JADE algorithm, our second step exploits all the structural information in the problem and consequently yields better performance. Simulation results demonstrating the improved performance over the JADE algorithm are included.
EXPERIMENTAL STUDY ON PERFORMANCE EVALUATION OF SFRC OVERLAYS AS A MEASURE TO IMPROVE DURABILITY OF EXISTING ORTHOTROPIC STEEL DECKS (2013)

既設鋼床版の疲労き裂への対策として，鋼繊維補強コンクリート（SFRC）舗装による補強工法が提案されている．この補強工法は，既設の舗装を剛性の高いSFRCに置き換え，デッキプレートとSFRC舗装を接着材により一体化させることで，鋼床版の局部応力の大幅な低減を図るものである．著者らは，同工法の実橋への適用にあたって，耐久性に係る信頼性を確保するために，小型試験体を用いた接着材接合面の強度試験，SFRC舗装を敷設した実大鋼床版試験体を用いた輪荷重走行試験を行い強度，耐久性を評価するとともに，試験結果や既往の施工事例等を踏まえ設計・施工法をとりまとめた．本文ではこれら一連の検討結果のうち，補強工法の概要を説明するとともに，接合面の耐久性の評価に関わる試験内容及び試験結果について報告する．
Crystal Engineering of Room-Temperature Ferroelectricity in epitaxial 1D Hollandite Oxides on Silicon (2020)

Ferroelectric oxides have attracted much attention due to their wide range of applications, especially in electronic devices such as nonvolatile memories, solar cells, and tunnel junctions. However, ferroelectrics are very few in nature and to achieve truly multifunctional oxide devices, these materials should be integrated in Silicon-based platforms. In this work, we used a chemical route to obtain nanowire films of a novel room-temperature ferroelectric Sr1+{\delta}Mn8O16 (SMO) hollandite oxide on silicon. Scanning transmission electron microscopy combined with crystallographic computing reveals a crystal structure comprising hollandite and pyrolusite units sharing the edges of their MnO6 octahedra, resulting in three types of tunnels arranged along the c axis, where ordering of the Sr atoms produces a natural symmetry breaking. The novel structure gives rise to a robust ferroelectricity and piezoelectricity, as revealed by Direct Piezoelectric Force Microscopy measurements, which confirmed the ferroelectric nature of SMO nanowire films at room temperature and showed a piezoelectric coefficient d33 value of 22 pC/N. Moreover, a first piezoelectric nanogenerator prototype based on vertical ultralong SMO nanowires was developed, showing an excellent deformability and high interface recombination. This work indicates the possibility of engineering the integration of piezoelectric and ferroelectric 1D hollandite thin films on silicon, a step which precedes the production of nanostructured and cost-efficient microelectronic devices.
A Longitudinal Study of Varicella Immunity in Pediatric Renal Transplant Recipients (1986)

Journal Article A Longitudinal Study of Varicella Immunity in Pediatric Renal Transplant Recipients Get access Howard Thachtman, Howard Thachtman Department of Pediatrics, Schneider Children's Hospital, New Hyde Park; Department of Pediatrics, Downstate Medical Center-SUNY, Brooklyn; and the Deparment of Pediatrics, New York University Medical Center, New York, New York Please address requests for reprints to Dr. Howard Trachtman, Division of Pediatric Nephrology, Schneider Children's Hospital of Long Island Jewish Medical Center, 271-16 76th Avenue, New Hyde Park, New York 11042 Search for other works by this author on: Oxford Academic PubMed Google Scholar Margaret R. Hammerschlag, Margaret R. Hammerschlag Department of Pediatrics, Schneider Children's Hospital, New Hyde Park; Department of Pediatrics, Downstate Medical Center-SUNY, Brooklyn; and the Deparment of Pediatrics, New York University Medical Center, New York, New York Search for other works by this author on: Oxford Academic PubMed Google Scholar Amir Tejani, Amir Tejani Department of Pediatrics, Schneider Children's Hospital, New Hyde Park; Department of Pediatrics, Downstate Medical Center-SUNY, Brooklyn; and the Deparment of Pediatrics, New York University Medical Center, New York, New York Search for other works by this author on: Oxford Academic PubMed Google Scholar Sharon Steinberg, Sharon Steinberg Department of Pediatrics, Schneider Children's Hospital, New Hyde Park; Department of Pediatrics, Downstate Medical Center-SUNY, Brooklyn; and the Deparment of Pediatrics, New York University Medical Center, New York, New York Search for other works by this author on: Oxford Academic PubMed Google Scholar Anne A. Gershon Anne A. Gershon Department of Pediatrics, Schneider Children's Hospital, New Hyde Park; Department of Pediatrics, Downstate Medical Center-SUNY, Brooklyn; and the Deparment of Pediatrics, New York University Medical Center, New York, New York Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Infectious Diseases, Volume 154, Issue 2, August 1986, Pages 335–337, https://doi.org/10.1093/infdis/154.2.335 Published: 01 August 1986 Article history Received: 19 November 1985 Revision received: 10 February 1986 Published: 01 August 1986
Provably correct implementation of the AbC calculus (2020)

Building open, distributed systems while guaranteeing a specific behaviour is difficult because of the dynamicity of the operating environments and the complexity of the interactions of their components. The AbC calculus provides a novel communication mechanism to select interacting partners based on their runtime capabilities, making it naturally to model complex interactions and adaptive behaviour in such systems. The formal account of this calculus has enabled constructing formally verifiable models and proving their properties. In this paper, we i) propose an implementation of AbC using the Erlang language ii) formalize the operational semantics of our implementation; iii) propose a set of rules that given an AbC specification, automatically generate Erlang executable code; and iv) prove that the proposed translation is correct by establishing a simulation relation between source and target specifications. This enables us to guarantee that any property proved for a given AbC specification is preserved by the corresponding implementation.
Effects of Escherichia coli K12 Biofilm on Sensor Thin Film Materials (2019)

Micro-fabricated sensors enable the study of chemical and physical dynamics in aqueous environments such as rivers, lakes or oceans at low cost. Sensors must work reliably in these environments, which include both biological and chemical challenges. However, sensor thin films have not been studied in detail for aqueous applications, and more specifically how biotic interactions may change sensor material properties. In this study, the long-term effects of biofilm formation on the properties of aluminum (electric conductor) and a-Si <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">y</sub> :H (insulating material) were investigated. Material degradation caused by Escherichia coli K12 biofilm growth was determined by electrical sheet resistance measurements (collinear four-point-probe) and Fourier-transform infrared spectroscopy (FTIR) absorption spectra over a time period of 7 weeks. Changes of the surface topography were tested using scanning electron microscopy (SEM) and white light interferometry. Aluminum was found to be heavily degraded at three weeks, whereas a-Si <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">y</sub> :H was inert during the entire investigation period. As differences between thin film sensor materials are evident, more detailed investigations including a broader range of materials should be explored.
Hypervisor-based fault tolerance (1995)

article Free Access Share on Hypervisor-based fault tolerance Authors: T. C. Bressoud Isis Distributed Systems, 55 Fairbanks Blvd., Marlborough, MA Isis Distributed Systems, 55 Fairbanks Blvd., Marlborough, MAView Profile , F. B. Schneider Computer Science Department, Cornell University, Ithaca, New York Computer Science Department, Cornell University, Ithaca, New YorkView Profile Authors Info & Claims ACM SIGOPS Operating Systems ReviewVolume 29Issue 5Dec. 3, 1995 pp 1–11https://doi.org/10.1145/224057.224058Published:03 December 1995Publication History 194citation1,685DownloadsMetricsTotal Citations194Total Downloads1,685Last 12 Months126Last 6 weeks24 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF