gebhart/patrepeval huggingface dataset:
P{Switch}, a system for spatial and temporal control of gene expression in Drosophila melanogaster (2001)

We have developed a method for turning on and off the expression of transgenes within Drosophila in both time and space. Two different enhancer detector elements carrying an RU486-inducible form of the yeast transcription factor GAL4 were constructed and used to generate enhancer detector lines. These lines were screened for RU486-inducible reporter gene expression in the adult head. We identified lines that exhibit inducible expression in many cell and tissue types, verifying that the elements respond to nearby enhancers. No expression was detected in the absence of the ligand. The P[Switch1] element responded to genomic enhancers less efficiently than P[Switch2] but produced more specific patterns of expression. Two P[Switch] lines were used to ablate fat body tissue in adult females through the induced expression of diphtheria toxin. These females were sterile, which correlates with fat body loss, and they died prematurely.
β-Si<sub>3</sub>N<sub>4</sub> whiskers prepared by heating a mixture of B<sub>2</sub>O<sub>3</sub> and α-Si<sub>3</sub>N<sub>4</sub> (2022)

Heating a mixture of α-Si3N4 and B2O3 at 2150 °C for 1 min under N2 at a pressure of 0.85 MPa was found to generate β-Si3N4 plate whiskers with widths of ∼10 µm, thicknesses of ∼0.2 µm and lengths greater than 2 mm. Boron nitride powder, β-Si3N4 platelet grains and a small amount of α-SiC grains were also obtained. Single crystal X-ray diffraction demonstrated that the whiskers were elongated in the c-axis direction and additional tests indicated elastic deformation of the whiskers.
Some principles of spatial organization in art (2007)

Rules of composition in paintings form a rich probe into the principles of perceptual processing that have been discussed for centuries. These principles can be studied by controlled scientific experiments, but an alternative approach is to use the art works themselves as a database for direct analysis. This paper focuses on the analysis of composition in relation to the canvas frame. An underlying principle is the compositional pyramid rising from the bottom of the frame to a center of consciousness high on the midline, which also finds its expression in the configuration of portrait paintings. The analyses presented reveal a dominant positioning principle for one eye in a portrait to lie on the vertical axis with an unbiased accuracy of the order of +/-5%. Analysis of the vertical location shows that the dominant height is at or above the Golden Section level on the vertical axis. In general, the layout of the portrait follows the principle of the compositional pyramid, with a center of consciousness at its apex, but there are many other compositional principles at work in the corpus of portraits in general. Analysis of the portraits of particular artists reveals that special features of their work must be considered in order to identify those that do and do not conform to the eye-centering principle.
Automatic Gender and Age Classification from Offline Handwriting with Bilinear ResNet (2022)

This work focuses on automatic gender and age prediction tasks from handwritten documents. This problem is of interest in a variety of fields, such as historical document analysis and forensic investigations. The challenge for automatic gender and age classification can be demonstrated by the relatively low performances of the existing methods. In addition, despite the success of CNN for gender classification, deep neural networks were never applied for age classification. The published works in this area mostly concentrate on English and Arabic languages. In addition to Arabic and English, this work also considers Hebrew, which was much less studied. Following the success of bilinear Convolutional Neural Network (B-CNN) for fine-grained classification, we propose a novel implementation of a B-CNN with ResNet blocks. To our knowledge, this is the first time the bilinear CNN is applied for writer demographics classification. In particular, this is the first attempt to apply a deep neural network for the <i>age</i> classification. We perform experiments on documents from three benchmark datasets written in three different languages and provide a thorough comparison with the results reported in the literature. B-ResNet was top-ranked in all tasks. In particular, B-ResNet outperformed other models on KHATT and QUWI datasets on gender classification.
Bit string analysis of Physical Unclonable Functions based on resistance variations in metals and transistors (2012)

Security mechanisms such as encryption, authentication and feature activation depend on the integrity of embedded secret keys. The mechanism by which these `digital secrets' are stored within Integrated Circuits (ICs) is changing from EPROMs and/or fuse technology to Physical Unclonable Functions (PUFs). PUFs leverage the naturally occurring manufacturing variations within each IC to produce repeatedly random digital identifiers. In this paper, we analyze the quality of the bit strings generated by PUFs that leverage resistance variations in 1) the power grid metal wires and transistor on-resistance in 60 copies of a 90 nm chip and 2) in the power grid metal wires of 58 copies of a 65 nm chip.
A tele-library service for the motor impaired : A qualitative study on the man/machine interface (1998)

On the road to UMTS, a need for ergonomic user centred design is emerging, especially for services on portable devices where screen space is restricted. This paper describes the development of a multimedia tele-library service accessible over a mobile network for people who are motor impaired, using iterative user trials to determine the interface design. This prototype allows consultation of a catalogue service and ordering and discussion of books remotely with library personnel through a real time video link. Initial user trials stressed the need to identify optimal on-screen sizes qf interface objects, which are practically usable for people who are motor impaired where screen space is limited. Recommendations from these studies have been applied in the prototype's user interface, which will be demonstrated. Future research will evaluate the tele-library prototype implemented in the homes of students who are motor impaired, with mobile access from a wireless LAN.
Combined laparoscopic cholecystectomy and selective vagotomy. (1991)

Laparoscopic surgery offers distinct advantages to traditional surgery, including decreased hospitalization and recovery periods, decreased postoperative discomfort, and improved cosmesis. A feasible laparoscopic approach to the treatment of peptic ulcer disease might confer similar patient benefits. A modified highly selective vagotomy (in combination with cholecystectomy for symptomatic cholelithiasis) has been successfully completed under laparoscopic guidance in a patient with intractable ulcer disease. The patient was discharged on the second postoperative day, tolerating a regular diet. The patient's dyspeptic symptoms disappeared during the immediate postoperative period and further endoscopic evaluation revealed resolution of active ulcer disease. Although experience is still limited in the United States, initial clinical results from Europe would indicate that laparoscopic vagotomy is not only feasible but effective. With further experience, laparoscopic vagotomy may provide a viable alternative to the standard treatment of peptic ulcer disease.
Spinoza and the Political Imaginary (2015)

Research Article| December 01 2015 Spinoza and the Political Imaginary Martin Saar Martin Saar Search for other works by this author on: This Site Google Qui Parle (2015) 23 (2): 115–133. https://doi.org/10.5250/quiparle.23.2.0115 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Permissions Cite Icon Cite Search Site Citation Martin Saar; Spinoza and the Political Imaginary. Qui Parle 1 December 2015; 23 (2): 115–133. doi: https://doi.org/10.5250/quiparle.23.2.0115 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search Books & JournalsAll JournalsQui Parle Search Advanced Search The text of this article is only available as a PDF. Copyright © 2015 Qui Parle2015 Article PDF first page preview Close Modal Issue Section: Articles You do not currently have access to this content.
Fighting fire with fire: the revival of thermotherapy for gliomas. (2014)

In 1891, an orthopedic surgeon in New York noted the disappearance of an inoperable sarcoma in a patient after a febrile illness. This observation resulted in experiments assessing the utility of heat therapy or thermotherapy for the treatment of cancer. While it initially fell from favor, thermotherapy has recently made a resurgence, sparking investigations into its anticancer properties. This therapy is especially attractive for glioblastoma multiforme (GBM) which is difficult to target due to the blood-brain barrier and recalcitrant to treatment. Here we briefly review the history of thermotherapy and then more methodically present the current literature as it relates to central nervous system malignancies. Recent developments show that heat is preferentially cytotoxic to tumor cells and induces cellular pathways which result in apoptotic and non-apoptotic death. Techniques to induce hyperthermia include regional hyperthermia by water bath, focused ultrasound, radiofrequency microwaves, laser-induced interstitial thermotherapy, and magnetic energy. The recent revival of these therapeutic approaches and their preliminary outcomes in the treatment of GBM is reviewed. From bacterial toxins to infusion of magnetic nanoparticles, hyperthermia has the potential to be an effective and easy-to-execute adjuvant therapy for GBM. Hyperthermia for GBM is a promising therapy as part of a growing armamentarium for malignant glioma treatment.
Adaptive Model Predictive Control for Fire Incidents in Water Distribution Networks (2021)

The real-time control of water distribution networks for firefighting is an important but little-studied problem. Water utilities in England and Wales reduce hydraulic pressure to a minimum regulatory threshold in order to reduce leakage and avoid financial penalties. However, utilities are not legally bound to guarantee specific flow rates from fire hydrants, which poses a risk for firefighting. This study presents an adaptive nonlinear model predictive control scheme for water distribution networks integrating two modes of control: (1) normal control, when a network operates under normal conditions and the objective is to minimize energy costs and average zonal pressure, and (2) fire control, when fire flows need to be delivered from hydrants without exceeding maximum pressure and customer demand is maintained to the best extent possible. The proposed scheme is applied to an operational network. It demonstrates the combined benefits of reducing costs and leakage with increased fire flows.
Turbine Engine Multi-Mission Propulsion Simulator Wind Tunnel Demonstration. (1976)

A turbine engine multi-mission propulsion simulator, developed by the Air Force Aero Propulsion Laboratory (AFAPL) to permit improved aircraft performance prediction capability through the simultaneous simulation of inlet/airframe/nozzle flowfields, was successfully demonstrated in a wind tunnel model tested in the Arnold Engineering Development Center 16 ft. Transonic Tunnel. The model tested is simple, featuring the forebody, inlet and nozzle of an advanced fighter aircraft, but no wings or tail surfaces. It is adaptable to three different test modes - simulator - equipped, conventional aero flow-through and conventional jet effects, and provides for the simultaneous measurement of the total airframe, aft-end and simulator forces and moments. Extensive pressure instrumentation is also provided on the fuselage for flowfield interaction studies. Wind tunnel test data was obtained from Mach 0.6 to 1.45, and at angles of attack from -1.6 to 16 degrees. The results of the test indicate that the propulsion simulator is a viable wind tunnel test tool that can be effectively operated under realistic test conditions. Comparison of the aerodynamic performance of this configuration, as obtained from both simulator and conventional test techniques, showed relatively small differences, thereby indicating small inlet/aft-end flowfield interactions for this inlet/nozzle spacing. Data repeatability obtained with the simulator model was comparable to that obtained on the conventional models. (Author)
Routing under constraints (2016)

Routing is an essential stage in physical design, where already placed components are connected by wires. Routing must satisfy various manufacturing requirements, referred to as design rules. We formalize the problem of design-rule-aware routing and introduce a solver, called DRouter, for the resulting problem. Plain routing is often modeled as follows: given an undirected weighted graph and a set of m disjoint nets (each net being a set of vertices), a routing is a (minimal) forest of m disjoint trees, where each tree spans a net. DRouter's input comprises a plain routing instance and a bit-vector formula, whose variables include the edges of the graph as Boolean variables (along with other variables). DRouter looks for a satisfying assignment to F, such that the satisfied edges comprise a routing. DRouter implements an A∗-based router inside a SAT solver. It overrides the solver's decision and restart strategies and enhances its learning with routing-aware algorithms. We demonstrate that, on a set of crafted routing instances, DRouter has substantially better capacity than either plain reduction to bit-vector reasoning or Monosat, a solver that is able to reason about SAT and graph predicates. We show that DRouter can route large clips from Intel designs while obeying up to millions of applications of the design rules — a task two industrial routers failed to accomplish.
Time-Resolved Spectroscopy of MBE-Grown InGaN/GaN Self-Formed Quantum Dots (2000)

GaInN/GaN quantum dots have been grown by molecular beam epitaxy on sapphire substrates. By changing the size and composition of the dots, the emission energy can be tuned over the entire visible spectrum. We present time-resolved photoluminescence obtained on such samples with emission energies ranging from 2.4 to 3.0 eV. We observe that the radiative recombination rate of electron–hole pairs varies over several decades, in correlation with the transition energy. When the decay time of the ground-state recombination reaches several microseconds, a much faster (nanoseconds) recombination is observed at higher energy. This is tentatively explained in terms of the partial screening of the internal field by a finite number of electron–hole pairs.
Phage HK022 Roi protein inhibits phage lytic growth in Escherichia coli integration host factor mutants (1996)

Temperate coliphage HK022 requires integration host factor (IHF) for lytic growth. The determinant responsible for this requirement was identified as a new gene (roi) located between genes P and Q. This gene encodes a DNA-binding protein (Roi) containing a helix-turn-helix motif. We have shown that Roi binds a site within its own gene that is closely linked to an IHF binding site. By gel retardation experiments, we have found that IHF binding stabilizes the interaction of Roi with its gene. We have isolated three independent phage mutants that are able to grow on an IHF- host. They carry different mutations scattered in the roi gene and specifying single amino-acid changes. The interactions of all three Roi mutant proteins with the Roi binding site differed from that of the wild type. Roi displays strong similarities, in its C-terminal half, to two putative DNA-binding proteins of bacteriophage P1: Ant1 and KilA. The mode of action of the Roi protein and the possibility that IHF is modulating the expression and/or the action of Roi are discussed.
Sparprojekt oder Milchmädchenrechnung? Die finanziellen Effekte eines Bundeslandes „Mitteldeutschland“ (2018)

In diesem Beitrag zeigen wir, dass die Fusion der Länder Sachsen, Sachsen-Anhalt und Thüringen zu einem Bundesland „Mitteldeutschland“ kaum Einsparungen erbringen würde. Eine Fusion würde weniger als 0,1 % der Landesausgaben (rund 2,90 Euro je Einwohner und Jahr) einsparen. Dies liegt daran, dass die überhaupt „einsparbaren“ Ausgabeposten (z. B. Ministerpräsidenten, Landtagsabgeordnete, Verfassungsgerichte) nur einen sehr kleinen Teil des Gesamthaushalts der Länder ausmachen. Der weit überragende Teil der Ausgaben der Länder – Aufwendungen für Lehrer, Justiz, Polizei und Kommunen – wäre von einer Fusion nicht berührt.
Granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor: differential action on incisional wound healing. (1994)

These results suggest GM-CSF is an activator of tissue macrophages and that increasing circulating WBC did not affect wound healing.
Inactivation of pathogens in platelet concentrates by using a two‐step procedure (2003)

Photodynamic treatment in the presence of the phenothiazine dye, thionine, followed by low-dose UVB, has the potential to inactivate viruses, leucocytes and bacteria, which might contaminate platelet concentrates. Both treatments complement each other.
Laser‐Raman spectroscopy of biomolecules. XI. Conformational study of poly(L‐valine) and copolymers of L‐valine and L‐alanine (1978)

Abstract Raman spectroscopic studies have been carried out on polymers of L ‐valine ranging in degree of polymerization ( DP ) from 2 to 930. The spectrum of the hexapeptide ( DP = 6) is closely similar over the entire range 40–1750 cm −1 to those of polymers with much higher DP , and the structure is clearly shown to be that of the antiparallel pleated sheet (β‐structure) by the amide I and III frequencies. The formation of a little α‐helical structure occurs in polymers with DP above 500, although the amount does not appear to be a linear function of DP . The α‐helical structure is unstable and readily destroyed in samples cast from trifluoroacetic acid solution. It is stabilized by the incorporation of L ‐alanine, a strong helix‐former; polymers of the latter may in turn be forced into a α‐structure in copolymers sufficiently rich in L ‐valine.
Scheduling Split Intervals Reuven Bar-Yehuda yz Magn us M. Halld orsson x Joseph (Se) Naor y (2005)

We consider the problem of scheduling jobs that are given as groups of non-intersecting segments on the real line. Each job Jj is associated with an interval, Ij, which consists of up to t segments, for some t 1, and a weight (prot), wj; two jobs are in conict if their intervals intersect. Such jobs show up in a wide range of applications, including the transmission of continuous-media data, allocation of linear resources (e.g. bandwidth in linear processor arrays), and in computational biology/geometry. The objective is to schedule a subset of non-conicting jobs of maximum total weight. Our problem can be formulated as the problem of nding a maximum weight independent set in a t-interval graph (the special case of t = 1 is an ordinary interval graph). We show that, for t 2, this problem is APX-hard, even for highly restricted instances. Our main result is a 2t-approximation algorithm for general instances. This is based on a novel fractional version of the Local Ratio technique. One implication of this result is the rst constant factor approximation for non-overlapping alignment of genomic sequences. We also derive a bi-criteria polynomial time approximation scheme for a restricted subclass of t-interval graphs.
On Properties, Relations, and Simplified Implementation of Filter Banks in the Dolby Digital (Plus) AC-3 Audio Coding Standards (2010)

The Dolby Digital (Plus) AC-3 audio coding standards are currently the key enabling technologies for high-quality compression and decompression of digital audio signals. The Dolby Digital (Plus) AC-3 audio coding standards have adopted the modified discrete cosine transform (MDCT) for the time/frequency transformation of an audio data block. Besides a long transform being the MDCT, the AC-3 defines additional two variants of cosine-modulated filter banks called the first and second short transforms. Based on the matrix representation of AC-3 filter banks, by a systematic investigation of their properties and relations among transform matrices, a relation between the frequency coefficients of the long (MDCT) and those of two short transforms is derived. Frequency coefficients of two short transforms in AC-3 can be simply obtained from the given frequency coefficients of the long (MDCT) transform via a conversion matrix. Since the conversion matrix after proper scaling is an orthonormal matrix with very regular general structure, the frequency coefficients of the short transforms can be converted to the frequency coefficients of the long (MDCT) transform via the transposed conversion matrix. Consequently, the current implementation of AC-3 filter banks for the time/frequency transformation of an audio data block can be simplified in the encoder and the forward long (MDCT) transform computation is required only. Further, it is shown that there exists a simple relation between the time domain aliased data sequence recovered by the backward long (MDCT) and those of two short transforms. Consequently, the current implementation of AC-3 filter banks can be also simplified in the decoder and the backward long (MDCT) transform computation is required only. Thus, the computation of two short transforms in both the AC-3 encoder and decoder can be completely eliminated. Moreover, due to the existence of both relations between transform coefficients and time domain aliased data sequences, the conversion matrix in the AC-3 encoder and decoder may not be used at all.