gebhart/patrepeval huggingface dataset:
Full-potential multiple-scattering theory without structure constants (1992)

A form of full-potential multiple-scattering theory for electrons in solids or molecules has recently been proposed in which the structure constants characteristic of standard theory (Korringa-Kohn-Rostoker) do not occur. This formalism was derived from the Lippmann-Schwinger integral equation and has been called the Green-function cellular method. It is shown here that this formalism is a restatement of the tail-cancellation condition of Andersen, applied originally in the context of his muffin-tin-orbital construction, using a local spherical approximation to the potential function in the Schr\"odinger equation. This was generalized to the atomic-cell orbital (ACO) construction for the full-potential problem by the present author. The equations of this method are derived here directly from the ACO tail-cancellation condition for boundary matching on the surface of each cell in a set of space-filling atomic cells, making no use of the free-particle or Helmholtz Green function. It is also shown here that these equations correspond to a restricted variation of trial functions on the surfaces of atomic cells in the context of the variational cellular method of Leite and collaborators, derived from the variational principle of Schlosser and Marcus.
Coordinated posttranscriptional control of gene expression by modular elements including Alu-like repetitive sequences. (1993)

We previously reported that in rat fibroblasts, accumulation of a set of mRNAs ("pIL genes") was modulated as a function of cell growth and transformation, at a posttranscriptional stage, and by a mechanism that depends on a short nucleotide sequence containing an ID repetitive element. In mouse fibroblasts, hybridization with rat pIL probes identified mRNAs with the same pattern of expression, which did not contain ID sequences but contained a different regulatory element, encompassing a repetitive sequence of the B1 family. Expression in mouse cells of a reporter beta-globin gene carrying this element inserted in its 3' noncoding region was growth- and transformation-dependent. The nucleotide sequences of two murine and of three rat pIL cDNAs showed clear similarities in the region immediately adjacent to the ID and B1 repeats. Both the repeat and the flanking sequence were required to confer on beta-globin constructs the pattern of expression characteristic of the pIL genes. The hypothesis is presented that repetitive sequences in the eukaryotic genome might be modular parts of complex regulatory elements ensuring the coordinated expression of various mRNA species.
Oxadiazole based bipolar host materials employing planarized triarylamine donors for RGB PHOLEDs with low efficiency roll-off (2014)

The impact of planarization of triarylamine donors on thermal, photo-physical and electro-chemical properties of novel materials is examined with regard to PHOLED applications.
Contribution of Reticulospinal Neurons to the Dynamic Control of Head Movements: Presumed Neck Bursters (1992)

Abstract This chapter only deals with the immediate premotor neuronal organization of this coordination at the level of the brain stem. It is known that the activity of the superior colliculus contributes to the initial saccade and the head movement. The afferent collicular neurons of the crossed tectoreticulospinal pathways activate a network of neurons in the brain stem that produces the premotor neuronal signals. It is well established that the signals that are carried by descending tectoreticulospinal neurons (TRSNs) are mainly phasic bursts. It is discussed that their firing rate is related to either eye velocity or dynamic motor error signals.
Ion implantation effect on vapor deposited organic solar cells based on pn junctions or interpenetrating networks of donor and acceptor small molecules (2004)

In this paper we report the achievement, with a co-evaporation set up, of photovoltaic cells based on single heterojunction or interpenetrating networks of organic donor and acceptor molecules as active layer. A donor-acceptor couple zinc phthalocyanine-C/sub 60/ (ZnPc-C/sub 60/) has been studied, sandwiched between indium tin oxide (ITO) and aluminum contacts. In the case of heterojunctions, sodium ion implantation of the C/sub 60/ layer or iodine ion implantation of the phthalocyanine layer improves the current-voltage I(V) characteristics of the single heterojunctions. An increase of both short circuit current Ice and open circuit voltage Voc has been noticed.
Validation of the Spanish version of the physical activity questionnaire used in the Nurses' Health Study and the Health Professionals' Follow-up Study (2005)

The moderate values obtained for correlation in a sub-optimal scenario for validity and the low percentage of extreme misclassification suggest the validity of the questionnaire to assess physical activity in Spanish-speaking women aged 20-50 years.
Promotion of mouse fibroblast collagen gene expression by mast cells stimulated via the Fc epsilon RI. Role for mast cell-derived transforming growth factor beta and tumor necrosis factor alpha. (1994)

Chronic allergic diseases and other disorders associated with mast cell activation can also be associated with tissue fibrosis, but a direct link between mast cell mediator release and fibroblast collagen gene expression has not been established. Using in situ hybridization, we show that the elicitation of an IgE-dependent passive cutaneous anaphylaxis (PCA) reaction in mice results in a transient, but marked augmentation of steady state levels of type alpha-1 (I) collagen mRNA in the dermis. While peak levels of collagen mRNA expression in the skin are observed 16-24 h after mast cell activation, substantial numbers of dermal cells are strongly positive for collagen mRNA at 1 and 2 h after antigen challenge, before circulating inflammatory cells are recruited into the tissues. Furthermore, experiments in mast cell-reconstituted or genetically mast cell-deficient WBB6F1-W/Wv mice demonstrate that the increased expression of collagen mRNA at sites of PCA reactions is entirely mast cell dependent. In vitro studies show that the supernatants of mouse serosal mast cells activated via the Fc epsilon RI markedly increase type alpha-1 (I) collagen mRNA levels in mouse embryonic skin fibroblasts, and also upregulate collagen secretion by these cells. The ability of mast cell supernatants to induce increased steady state levels of collagen mRNA in mouse skin fibroblasts is markedly diminished by absorption with antibodies specific for either of two mast cell-derived cytokines, transforming growth factor beta (TGF-beta 1) or tumor necrosis factor alpha (TNF-alpha), and is eliminated entirely by absorption with antibodies against both cytokines. Taken together, these findings demonstrate that IgE-dependent mouse mast cell activation can induce a transient and marked increase in steady state levels of type alpha-1 (I) collagen mRNA in dermal fibroblasts and that mast cell-derived TGF-beta 1 and TNF-alpha importantly contribute to this effect.
A Naval Integrated Power System with a Battery Energy Storage System: Fuel efficiency, reliability, and quality of power (2015)

Mechanical machinery has dominated the field of ship propulsion systems in the last century. Since fuel accounts for a large portion of the ship life-cycle cost, the current trend of moving toward fuel economy and environmental regulations in marine engineering has led to the efficient use of onboard energy. Incorporating power electronics into ship propulsion systems has been a very common method of improving fuel efficiency since approximately 1980. One high-profile example is the 1968-built Queen Elizabeth 2, whose steam turbines were replaced with a diesel-electric propulsion plant in 1986. Some commercial ships are now being built with electric drives, such as passenger ships, car ferries, shuttle tankers, cable-laying ships, icebreakers, and floating offshore platforms. Navies around the world have been actively exploring integrated power systems (IPSs) for use on future surface combatant ships since the late 20th ?century. Although the ship IPS has many distinct advantages, such as increased survivability and maneuverability, reliability inhibits further fuel economy improvement. The onboard battery energy storage system (BESS) was recently suggested to increase fuel economy and ensure reliability at the same time. Furthermore, an active front-end (AFE) converter can provide improved grid quality at transient states such as fault and future mission load in addition to steady state as with normal sea sailing.
Single chip, self supplied, voltage and charge mode double 80V piezoelectric actuator driver (1999)

A single chip piezoelectric double actuator driver is presented. It is able to drive up to 24 nF of capacitive load with up to 100 mA of current and 80 V of output swing. It offers both voltage-control and charge-control configurations to minimize piezoelectric ceramic hysteresis effects. The chip can be supplied from 5 to 12 V and generates internally +-40V or 0-80V by means of a quasi-resonant boost converter designed to reduce high dV/dt noise problems. A -2.5 V analog level shifter is included so that the chip can be driven with a DAC output spanning from 0 to 5V of dynamic range, thus maintaining the symmetry to ground.
Discovery to delivery in tendon research (2019)

Tendon-related pathologies lead to significant disability, pain, and cost, with few effective treatment approaches. Tendinopathies are highly prevalent, making up 30% of musculoskeletal primary care visits.1 For example, rotator cuff tendinopathy affects 17 million people in the United States, and outcomes after surgical repair of torn cuff tendons remain poor, despite decades of work optimizing repair techniques and rehabilitation strategies.2 At the root of these poor outcomes is a lack of understanding of tendon biology, pathogenesis, and healing. Motivated by this, the Tendon Section of the Orthopaedic Research Society met in Portland, OR on November 15–17, 2018 to discuss “Discovery to Delivery in Tendon Research”. This special issue is one outcome from the meeting, compiling critical reviews and original papers that focus on the path from basic science discovery to delivery of effective treatments for tendinopathies. Reviews cover the state of our understanding of normal and diabetic tendon healing3, 4 and the role of the extracellular matrix in tendon development and homeostatis.5 A series of original research papers delves into tendon pathogenesis and healing, focusing on a broad range of topics: the effect of age and fatigue on tendon biomechanics,6 transcriptomics analysis of tendon healing,7 and treatment strategies that include hyaluronidase,8 pulsed electromagnetic fields,9 and parathyroid hormone.10 A collection of stem cell papers describes methods to generate and optimize stem cells11, 12 and uses them to enhance tendon healing.13, 14 In vitro models are used to examine how dexamethasone can protect the tendon from degeneration,15 the roles of substrate stiffness and pulsed electromagnetic fields in tendon responses to inflammation,16, 17 and tendon responses to mechanical loading.18 Finally, a series of papers examines the risk factors and susceptibility for rotator cuff disease and injury19-22 and the use of imaging modalities to assess changes to the cuff after repair.23 This special issue demonstrates exciting progress in the field towards understanding tendon pathogenesis and healing and presents a number of novel strategies to prevent disease progression and improve healing. Many open questions remain, however, for translating these and other discoveries to patient care.
The 4q25 variant rs13143308T links risk of atrial fibrillation to defective calcium homoeostasis (2018)

Here, we identify the 4q25 variant rs13143308T as a genetic risk marker for AF, specifically associated with excessive calcium release and spontaneous electrical activity linked to increased SERCA2 expression and RyR2 phosphorylation.
New Palladium(II) and Platinum(II) Complexes with the Model Nucleobase 1-Methylcytosine:  Antitumor Activity and Interactions with DNA (2005)

Palladium and platinum complexes with the model nucleobase 1-methylcytosine (1-Mecyt) of the types [Pd(N-N)(C6F5)(1-Mecyt)]ClO4 [N-N = bis(3,5-dimethylpyrazol-1-yl)methane (bpzm), bis(pyrazol-1-yl)methane (bpzm), N,N,N',N'-tetramethylethylenediamine (tmeda), or 2,2'-bipyridine (bpy)] and [M(dmba)(L')(1-Mecyt)]ClO4 [dmba = N,C-chelating 2-(dimethylaminomethyl)phenyl; L' = PPh(3) (M = Pd or Pt), DMSO (M = Pt)] have been obtained. Palladium and platinum complexes of the types cis-[M(C6F5)2(1-Mecyt)2] (M = Pd or Pt) and cis-[Pd(L')(C6F5)(1-Mecyt)2]ClO4 (L' = PPh(3) or t-BuNC) have also been prepared. The crystal structures of [Pd(bpzm)(C6F5)(1-Mecyt)]ClO4, [Pt(dmba)(DMSO)(1-Mecyt)]ClO4, cis-[Pd(C6F5)2(1-Mecyt)2], and cis-[Pd(t-BuNC)(C6F5)(1-Mecyt)2]ClO4 have been established by X-ray diffraction. There is extensive hydrogen bonding (N-H...O, C-H...F or C-H...O) in all the compounds. There are also intermolecular pi-pi interactions between pyrimidine rings of adjacent chains in [Pd(C6F5)2(1-Mecyt)2]. DNA adduct formation of the new complexes synthesized was followed by circular dichroism and electrophoretic mobility. Atomic force microscopy images of the modifications caused by the complexes on plasmid DNA pBR322 were also obtained. Values of IC(50) were also calculated for the new complexes against the tumor cell line HL-60. At a short incubation time (24 h) almost all new complexes were more active than cisplatin.
Brief Report: Urine Emtricitabine and Tenofovir Concentrations Provide Markers of Recent Antiretroviral Drug Exposure Among HIV-Negative Men Who Have Sex With Men (2019)

High urine FTC and TFV concentrations could provide an indication of adherence to daily oral dosing with TDF or TAF-based regimens used for treatment and prevention.
Analysis of free fractions for chiral drugs using ultrafast extraction and multi-dimensional high-performance affinity chromatography (2013)

A multi-dimensional chromatographic approach was developed to measure the free fractions of drug enantiomers in samples that also contained a binding protein or serum. This method, which combined ultrafast affinity extraction with a chiral stationary phase, was demonstrated using the drug warfarin and the protein human serum albumin.
Improvement in Stretch Flange Ability of High-Tensile-Strength Steel Sheets by Piercing under Tension Using Humped Bottom Punch (2012)

To meet the requirements for the weight reduction of automobiles, high-tensile-strength steel sheets have been applied extensively to the manufacture of auto parts. But their relatively lower press formability has obstructed their further application, and it is strongly demanded that the stretch flange ability of such steel sheets be increased, and cracks that occur when stretching edges during the press forming of such steel sheets be suppressed. Thus the authors have carried out a study to improve the stretch flange ability of high-tensile-strength steel sheets by optimizing the punching method and obtained the following conclusions. Work hardening on a pierced edge is mainly caused by deformation by the punch motion while shearing the material. By attaching a hump of certain shape at the bottom of the punch, the ductile fracture in the material caused by the punch corner is accelerated by the hump′s effect to increase stress triaxiality, which reduces the extent of total deformation through shearing, thereby improving the stretch flange ability of the material.
Effect of Ciclosporin on Allogeneic Hepatocyte Transplantation: A Morphological Study (1988)

Hepatocyte transplantation (HT) is among the most frequently employed approaches in the treatment of liver disease. This work deals with the occurrence of rejection when allogeneic hepatocytes are transplanted into the spleens of rats. Two strains of rats were used: Lewis and F344. The recipients were divided into two groups, one of which received ciclosporin (Cic), while the other received no treatment. After HT, the spleens were removed periodically. The animals that did not receive Cic suffered such intense rejection that 7 days after HT no hepatocytes could be identified in the splenic pulp. On the other hand, hepatocytes could be observed throughout the entire study in the spleens of rats treated with Cic. We conclude that HT is followed by intense rejection, which can be avoided by the administration of Cic.
Isolated Brain Microvessels: A Purified, Metabolically Active Preparation from Bovine Cerebral Cortex (1974)

A purified, metabolically active preparation of brain microvessels was isolated from bovine cerebral cortex by using a simple procedure involving mild disruption of the tissue by homogenization and trapping of the vessels on nylon sieves. This preparation permits in vitro metabolic and structural studies of small blood vessels.
37. Capacity of Viral Genome Packaging and Internal Volumes of AAV Viral Particles (2015)

Adeno-associated virus (AAV) vectors have widely been used in many preclinical and clinical studies, showing promise as the most effective in vivo gene delivery vector. Despite successful application of AAV vector-mediated gene therapy to the treatment of certain genetic diseases such as hemophilia, the inability to package genomes of longer than 5 kb has precluded broader applications of this approach. Whether or not longer genomes would become able to be packaged by viral capsid engineering has yet to be determined; however, what is lacking in this field is comprehensive understanding of the maximal capacity of genome packaging in various AAV serotypes through a systematic analysis. Here we developed a novel computational algorithm to calculate the capsid internal volume that minimizes approximation and determine the internal volumes of 22 eukaryotic viruses with T=1 icosahedral symmetry including 16 viruses that belong to the family of Parvoviridae. In addition, we systematically determine the maximal packaging capacity of both VP1/VP2/VP3 capsids and VP3 only capsids derived from various serotypes using a panel of recombinant AAV2 vector genomes of varying sizes from 4.80 kb up to 6.00 kb by an increment of 0.05 kb, termed ruler genomes. To determine capsid internal volumes, three dimensional structure coordinates of each viral capsid were retrieved from the Protein Data Bank, and then, using an algorithm we have developed, each atom was inflated in such a way that interstices between adjacent atoms in the protein shell are effectively filled with protein while keeping the shape of the inner surface of the capsid unchanged. The internal volume of the capsid was then calculated by a numerical integration of coordinates in the non-protein space that were closer to the center than the atom that is most distant from the center of the capsid. By this method, we find that the genome lengths and internal volumes of the 22 eukaryotic T=1 viruses that we analyzed vary from 0.83 kb to 6.04 kb and from 6.72 × 105 to 3.46 × 106 Å3, respectively, showing a strong non-linear allometric relationship with an exponent of 1.30 (R2=0.97). In the following AAV serotypes, AAV1, 2, 3B, 4, 5, 6, 8 and 9, AAV5 is found to have a distinctively smaller volume (2.48 × 106 Å3) compared to the other 7 serotypes (2.62±0.03 × 106 Å3, mean±SD). This analysis also reveals that AAV2 VP3 only capsid has a 7% larger volume than AAV2 VP1/VP2/VP3 capsid. In keeping with this observation, a preliminary study using the ruler genomes has indicated that the AAV2 VP3 capsid can package a genome that is longer than that can be packaged in the AAV2 VP1/VP2/VP3 capsid by several hundred nucleotides, which appears to correspond to the difference in the volume of the two different capsids. Investigation of other serotypes and capsid mutants is currently underway. Thus, the approach presented here will help understand the genome packaging and provide insights into how to design capsids to overcome packaging limitations.
Nucleosome destabilization by polyamines (2022)

The roles and molecular interactions of polyamines (PAs) in the nucleus are not fully understood. Here their effect on nucleosome stability, a key regulatory factor in eukaryotic gene control, is reported, as measured in agarose embedded nuclei of H2B-GFP expressor HeLa cells. Nucleosome stability was assessed by quantitative microscopy [1,2] in situ, in close to native state of chromatin, preserving the nucleosome constrained topology of the genomic DNA. A robust destabilizing effect was observed in the millimolar concentration range in the case of spermine, spermidine as well as putrescine, which was strongly pH and salt concentration-dependent, and remained significant also at neutral pH. The integrity of genomic DNA was not affected by PA treatment, excluding DNA break-elicited topological relaxation as a factor in destabilization. The binding of PAs to DNA was demonstrated by the displacement of ethidium bromide, both from deproteinized nuclear halos and from plasmid DNA. The possibility that DNA methylation patterns may be influenced by PA levels is contemplated in the context of gene expression and DNA methylation correlations identified in the NCI-60 panel-based CellMiner database: methylated loci in subsets of high-ODC1 cell lines and the dependence of PER3 DNA methylation on PA metabolism.
Speed measurement algorithm for low speed permanent magnet synchronous motor based on overlapped measurement regions (2016)

In order to improve the speed measurement performance of low speed PMSM drives equipped with absolute optical encoders, this paper proposes a speed measurement method based on overlapped measurement regions. The proposed method replaces the long measurement region of the conventional backward differentiation method with several short ones which are overlapped at most regions. In one speed measurement process, the results obtained from the short regions are averaged to improve precision. Then the relationship between precision, time delay and region length, overlap times, are analyzed using expectation and variance as performance index. Based on the analysis, an optimal design method of the measurement region is derived. Experimental researches are carried out on a low speed permanent magnet synchronous motor equipped with a 13 bit absolute encoder. The results prove the validity and effectiveness of the proposed method.
Senile macular degeneration. The involvement of giant cells in atrophy of the retinal pigment epithelium. (1986)

Senile macular degeneration (SMD) is a leading cause of registered blindness in the United States and other Western countries. Loss of central vision develops as a result of atrophy of the retinal pigment epithelium or subretinal neovascularisation. The histopathology of the atrophic form of SMD has not been extensively studied. This paper illustrates at the light and electron microscope level the involvement the atrophic form of SMD. Additional features including pigment clumping and detachment of the retinal pigment epithelium at the advancing edge of the lesion are illustrated. Giant cells and MPS cells are typical features of granulomatous inflammation, and results suggest that they may play a role in the pathogenesis of SMD.
About the influence of nano-precipitation and cold- working on the recrystallization mechanisms in ferritic ODS materials (2017)

International audience
High Expression Level of PPARγ in CD24 Knockout Mice and Gender-Specific Metabolic Changes: A Model of Insulin-Sensitive Obesity (2021)

CD24 may negatively regulate PPARγ expression in male mice. Furthermore, the association between the CD24 and insulin sensitivity suggests a possible mechanism for diabetes as a cancer risk factor. Finally, CD24 KO male mice may serve as a model of obesity and insulin hyper-sensitivity.