gebhart/patrepeval huggingface dataset:
The Us9 Gene Product of Pseudorabies Virus, an Alphaherpesvirus, Is a Phosphorylated, Tail-Anchored Type II Membrane Protein (1998)

The Us9 gene is highly conserved among the alphaherpesviruses sequenced to date, yet its function remains unknown. In this report, we demonstrate that the pseudorabies virus (PRV) Us9 protein is present in infected cell lysates as several phosphorylated polypeptides ranging from 17 to 20 kDa. Synthesis is first detected at 6 h postinfection and is sensitive to the DNA synthesis inhibitor phosphonoacetic acid. Unlike the herpes simplex virus type 1 Us9 homolog, which was reported to be associated with nucleocapsids in the nuclei of infected cells (M. C. Frame, D. J. McGeoch, F. J. Rixon, A. C. Orr, and H. S. Marsden, Virology 150:321-332, 1986), PRV Us9 localizes to the secretory pathway (predominately to the Golgi apparatus) and not to the nucleus. By fusing the enhanced green fluorescent protein (EGFP) reporter molecule to the carboxy terminus of Us9, we demonstrated that Us9 not only is capable of targeting a Us9-EGFP fusion protein to the Golgi compartment but also is able to direct efficient incorporation of such chimeric molecules into infectious viral particles. Moreover, through protease digestion experiments with Us9-EGFP-containing viral particles, we demonstrated that the Us9 protein is inserted into the viral envelope as a type II, tail-anchored membrane protein.
Heterogeneous grain-scale response in ferroic polycrystals under electric field (2016)

Understanding coupling of ferroic properties over grain boundaries and within clusters of grains in polycrystalline materials is hindered due to a lack of direct experimental methods to probe the behaviour of individual grains in the bulk of a material. Here, a variant of three-dimensional X-ray diffraction (3D-XRD) is used to resolve the non-180° ferroelectric domain switching strain components of 191 grains from the bulk of a polycrystalline electro-ceramic that has undergone an electric-field-induced phase transformation. It is found that while the orientation of a given grain relative to the field direction has a significant influence on the phase and resultant domain texture, there are large deviations from the average behaviour at the grain scale. It is suggested that these deviations arise from local strain and electric field neighbourhoods being highly heterogeneous within the bulk polycrystal. Additionally, the minimisation of electrostatic potentials at the grain boundaries due to interacting ferroelectric domains must also be considered. It is found that the local grain-scale deviations average out over approximately 10-20 grains. These results provide unique insight into the grain-scale interactions of ferroic materials and will be of value for future efforts to comprehensively model these and related materials at that length-scale.
Ivabradine: a preliminary observation for a new terapeutic role in patients with multiple organ dysfunction syndrome (2014)

Sirs: Severe sepsis is a major cause of mortality and morbidity worldwide. Septic patients often develop multiple organ dysfunction syndrome (MODS) that is characterized by an acute functional impairment of two or more organs so that homeostasis cannot be maintained without intervention [1]. Patients with MODS typically present with an elevated heart rate (HR) that accompanies a highly impaired autonomic dysfunction with depressed parasympathetic control of the heart. An elevated heart rate was found to increase the incidence of major cardiac events in critically ill patients [2–4]. Furthermore, an elevated heart rate in the early phase of MODS was found to be an independent
New stopping criteria for iterative decoding of LDPC codes in H‐ARQ systems (2012)

SUMMARY Under severely unreliable channel, decoding of error‐correcting codes frequently fails, which requires a lot of computational complexity, especially, in the iterative decoding algorithm. In hybrid automatic repeat request systems, most of computation power is wasted on failed decoding if a codeword is retransmitted many times. Therefore, early stopping of iterative decoding needs to be adopted. In this paper, we propose a new stopping algorithm of iterative belief propagation decoding for low‐density parity‐check codes, which is effective on both high and low signal‐to‐noise ratio ranges and scalable to variable code rate and length. The proposed stopping algorithm combines several good stopping criteria. Each criterion is extremely simple and will not be a burden to the overall system. With the proposed stopping algorithm, it is shown via numerical analysis that the decoding complexity of hybrid automatic repeat request system with adaptive modulation and coding scheme can be fairly reduced. Copyright © 2012 John Wiley &amp; Sons, Ltd.
BROWNING OF SAGO (METROXYLON SAGU) PITH SLURRY AS INFLUENCED BY HOLDING TIME, pH AND TEMPERATURE (2004)

The effect of holding time, pH and temperature of sago pith slurry on its browning was evaluated. Holding time of sago pith slurry, which browning took place, proved to be an important factor in determining the amount of soluble phenolic compounds that were oxidized. This subsequently led to the development of color. The amount of (+)-catechin and (-)-epicatechin that was oxidized increased with pH particularly above pH 4.5. This resulted in simultaneous development of color in the sago pith slurry. The oxidation of phenolic compounds in acidic conditions was suggested to be caused by latent polyphenol oxidase (LPPO) as it is activated by acidic pH. The amount (+)-catechin and (-)-epicatechin oxidized also increased with increase in temperature particularly above 30C.
Beating effect between a thermoacoustic source and its mechanical partner (2015)

Beating effects between a thermoacoustic source and its mechanical partner-a piston-spring oscillator are numerically predicted and experimentally observed in the free-decay process. Through analyzing the indicator diagram, periodic energy transfer characteristics between a thermoacoustic source and its mechanical partner during the beating oscillation are revealed and analyzed. The oscillation frequency is found to split into two modes intrinsically even when the resonance frequencies are initially tuned to be the same. The patterns and frequencies of the beating oscillations are sensitively affected by the characteristics of acoustic sources. The study sheds light on the underlying mechanisms of beating oscillations occurred in thermoacoustic systems with multiple resonant sub-units.
A structural model of a short carboxyl-imidazole hydrogen bond with a nearly centrally located proton: implications for the Asp-His dyad in serine proteases (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA structural model of a short carboxyl-imidazole hydrogen bond with a nearly centrally located proton: implications for the Asp-His dyad in serine proteasesRichard D. Gandour, Nabeel A. R. Nabulsi, and Frank R. FronczekCite this: J. Am. Chem. Soc. 1990, 112, 21, 7816–7817Publication Date (Print):October 1, 1990Publication History Published online1 May 2002Published inissue 1 October 1990https://doi.org/10.1021/ja00177a064RIGHTS & PERMISSIONSArticle Views205Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (317 KB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Rotatostereoradiography: A New Radiodiagnostic Method (1991)

The rotatostereoradiographic device uses an x-ray tube coupled with an image intensifier rotating through a 180 degree arc in 2.25 seconds. The rapidly rotating x-ray tube allows 180 degree-arc angiograms to be obtained with a single injection of contrast medium. Subtracted fluoroscopic angiograms can be viewed immediately after injection of the contrast medium with digital recording. These three-dimensional images are displayed on side-by-side monitors stereoscopically. The mortality and morbidity of subarachnoid hemorrhage can only be greatly reduced by surgical treatment of unruptured aneurysms and arteriovenous malformations detected by a wide survey of subarachnoid hemorrhage. Such a wide survey would be possible utilizing intra-arterial digital subtraction angiography via the ascending aorta and this new three-dimensional radiodiagnostic method. A fluoroscopic device must be used to allow easier manipulation of the catheter from the axillary or brachial artery.
Adenosine receptor targeting in health and disease (2011)

Selective ligands of A(1), A(2A), A(2B) and A(3) adenosine receptors are likely to find applications in the treatment of pain, ischemic conditions, glaucoma, asthma, arthritis, cancer and other disorders in which inflammation is a feature. The aim of this review is to provide an overview of the present knowledge regarding the role of these adenosine receptors in health and disease.
Role of Clopidogrel in Managing Atherothrombotic Cardiovascular Disease (2007)

Aspirin is the most widely used antiplatelet agent for preventing and treating vascular events. The thienopyridine derivatives, ticlopidine and clopidogrel, are a suitable alternative in patients who are intolerant to aspirin, and clopidogrel exhibits better tolerability than ticlopidine. The available evidence from randomized trials indicates that dual therapy with clopidogrel and aspirin is modestly but significantly more effective than aspirin in preventing serious vascular events. It is also associated with a favorable benefit-risk profile in patients at high risk (especially in acute coronary syndromes and after stenting). In patients at low risk (stable cardiovascular disease), however, the bleeding risk of dual therapy exceeds its potential benefit. The dose and duration of pretreatment before stenting, the optimal duration of treatment after drug-eluting stent implantation, concurrent administration of platelet glycoprotein IIb/IIIa inhibitors, and the exact mechanism and clinical relevance of clopidogrel resistance are unclear.
Total Synthesis of an Atropdiastereomer of RP‐66453 and Determination of Its Absolute Configuration (2003)

Die absolute Konfiguration des Naturstoffs RP-66453 (1) wurde durch Totalsynthese seines Atropdiastereomers und spektroskopische Studien beider Verbindungen zu aR, S, S, S, S, S bestimmt. Eine SNAr-basierte cyclische Etherbildung und eine intramolekulare atropdiastereoselektive Suzuki-Miyaura-Kupplung wurden zum Aufbau des schwer zugänglichen bicyclischen A-B-O-C-Gerüsts von RP-66453 genutzt. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2003/z51996_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Dynamic Characteristic Analysis and Machining Error Study Based on Solid Vibration Beam Rate Sensor (2010)

Machining error of vibration beam rate sensor and its influencing to the performance of solid vibration inertial sensor were studied. The dynamics model was analyzed, and the mechanism error caused by the technology limit was studied and the theory of deducing the error was presented. Numerical calculations combined with 100mm alloyed vibration beam have been made. Results showed that quadrature error is the primary factor of affecting gyro’s performance; the error caused by mass center deviation of vibration beam change with angular acceleration, which can be ignored under the condition that small angular acceleration. The affects of parasitic Coriolis error on performance is minimal, which can be neglected. Finally, the quadrature error’s simulation results were consistent with expected results. The result also proved that restraining and compensating quadrature errors is one of the key technology to increase the performance.
To spend or not to spend? The effect of budget constraints on estimation processes and spending behavior (2005)

Both marketing and economic budget-allocation and spend-ing-behavior models often assume that consumers know the prices of the products they buy and hence are knowledgeable about the total value of their shopping basket as they shop (e.g., Frank et al.
Effect of diffusion on impedance measurements in a hydrodynamic flow focusing sensor (2010)

This paper investigated the effects of diffusion between non-conductive sheath and conductive sample fluids in an impedance-based biosensor. Impedance measurements were made with 2- and 4-electrode configurations. The 4-electrode design offers the advantage of impedance measurements at low frequencies (<1 kHz) without the deleterious effects of double layer impedance which are present in the 2-electrode design. Hydrodynamic flow focusing was achieved with a modified T-junction design with a smaller cross-section for the sample channel than for the focusing channel, which resulted in 2D focusing of the sample stream with just one sheath stream. By choosing a non-conductive sheath fluid and a conductive sample fluid, the electric field was confined to the focused stream. In order to utilize this system for biosensing applications, we characterized it for electrical and flow parameters. In particular, we investigated the effects of varying flow velocities and flow-rate ratios on the focused stream. Increasing flow-rate ratios reduced the cross-sectional area of the focused streams as was verified by finite element modeling and confocal microscopy. Antibody mediated binding of Escherichia coli to the electrode surface caused an increase in solution resistance at low frequencies. The results also showed that the diffusion mass transport at the interface of the two streams limited the benefits of increased flow focusing. Increasing flow velocities could be used to offset the diffusion effect. To optimize detection sensitivity, flow parameters and mass transport must be considered in conjunction, with the goal of reducing diffusion of conducting species out of the focused stream while simultaneously minimizing its cross-sectional area.
Daptomycin synergy with rifampicin and ampicillin against vancomycin-resistant enterococci (2004)

We used a novel screening method to look for synergy between daptomycin and 18 other antibiotics against 19 strains of high-level vancomycin-resistant enterococci (VRE) (vancomycin MIC > or = 256 mg/L). In this approach, daptomycin was incorporated into Ca(2+)-supplemented Mueller-Hinton agar at subinhibitory concentrations, and synergy was screened by comparing test antibiotic Etest MICs on agar with and without daptomycin. A striking reduction in the rifampicin MIC was seen in 11/15 (73.3%) VRE that were resistant to rifampicin, from > or =12 mg/L to a mean +/- s.d. of 0.22 +/- 0.21 mg/L at daptomycin 0.25 x MIC and 0.85 +/- 0.90 mg/L at daptomycin 0.125 x MIC. Synergy was also observed for 13/19 (68%) isolates with ampicillin (MIC > or = 128 mg/L). There was no significant synergy between daptomycin and any other antibiotic by this screening method. If confirmed by further studies, daptomycin with either rifampicin or ampicillin may be useful in the management of infections caused by VRE.
Electron gun for microwave tubes with cold field emitting cathodes (2002)

The latest achievements in technology of diamond-like carbon films deposition have made it possible to obtain emitters capable of operating in a technical vacuum with average current density 1-2 A/n/spl tilde/i/sup 2/ at macroscopic electric fields on the cathode 6-7 kV/mm. This discovers the opportunities of creation of new class of electron guns for industrial microwave tubes (TWTs, klystrons) having unique features: instant turn-on time, absence of heating power, high time of life, increased electrodes' stability and absence of cathode sputtering.
Metabolic breath signature of 13C-enriched wheat bran consumption related to gut fermentation in humans: a Fiber-TAG study (2020)

Abstract Introduction Dietary fibers (DF) have been classified mainly according to their physico-chemical and fermentability properties but it remains unclear whether such classification is relevant when addressing their health effects. Indeed, the nature of physiological effects induced by DF, particularly through their interaction with gut microbiota, remains poorly known due to their diversity, to gut microbiota inter-subjects variability and to the lack of validated non-invasive biomarkers to characterize DF-gut microbiota interaction. The aim of this pilot study was 1) to follow the metabolic fate of 13 C-labeled DF through the assessment of 13 C-labelled gut-derived metabolites in excreted breath and 2) to evaluate novel non-invasive breath-derived biomarkers of DF-gut microbiota interactions. Materials and methods Six healthy women (29.7 ± 1.7 years old, BMI: 23.2 ± 0.9kg/m 2 , fiber intake: 23 ± 1g/d) consumed in research settings a controlled breakfast containing eight 13 C-labelled wheat bran biscuits (50 g of labelled wheat bran, 3.0At% 13 C). 13 C-labelled wheat bran was obtained from wheat cultivated under 13 CO 2 enriched atmosphere. Samples of expired gases were collected during 24 h after ingestion in order to measure H 2 and CH 4 by gas chromatography (GC) with piezoelectric detection and 13 CO 2 and 13 CH 4 by gas chromatography coupled with an isotope ratio mass spectrometer (GC-IRMS). Apart test breakfast, subjects only consumed standardized meals without fibers. Results The analysis of H 2 and CH 4 24h-kinetic measurements distinguished 2 groups in terms of fermentation related gas excretion: the high-CH 4 producers with high baseline CH 4 concentrations (42.1 ± 13.7ppm) and low baseline H 2 concentrations (7.3 ± 5.8ppm) and the low-CH 4 producers with low baseline CH 4 concentrations (6.5 ± 3.6ppm) and high baseline H 2 concentrations (20.8 ± 16.0ppm). Following the 13 C-wheat bran biscuits’ ingestion, postprandial H 2 and CH 4 concentrations increased more significantly in the high-CH 4 producer subjects. 13 C enrichment was detectable in expired gases in all subjects. 13 CO 2 kinetics were similar for all subjects and correspond to the oxidation of the digestible part of the bran. The appearance of 13 CH 4 was significantly enhanced and prolonged after 180 min in high-CH 4 producers compared to low-CH 4 producers, suggesting distinct fiber fermentation profile. Discussion This pilot study allowed to consider novel procedures for development of non-invasive breath biomarkers of fiber-gut microbiota interactions. Assessment of expired gas excretion following 13 C-labelled fiber ingestion allowed deciphering distinct fermentation profiles: high-CH 4 producers vs low-CH 4 producers and accordingly provide a related non-invasive breath metabolic signature of the fiber fermentation for each profile. Further gut microbiota and 13 C-metabolites analysis will permit to relate the gut bacteria composition with breath gas excretion kinetics according to fiber fermentation profile.
Supplementary Figure 1 from Human Endogenous Retrovirus K Triggers an Antigen-Specific Immune Response in Breast Cancer Patients (2023)

Supplementary Figure 1 from Human Endogenous Retrovirus K Triggers an Antigen-Specific Immune Response in Breast Cancer Patients
A new 2-D exact moment recovery with application to fast frequency response estimation (2003)

The estimation of a system's frequency response, and hence of its transfer function, is of great practical importance in signal processing, identification and control. The powerful quadrature correlation technique is very well-suited for this situation task and is still enjoying a widespread use because of its ease of use, excellent harmonic and noise rejection capabilities. Its practical implementation ranges from the purely repetitive, single frequency version to the fully parallel multifrequency one. The latter version is superior to the former one in terms of speed of estimation but suffers form tile cost of its parallel structure that becomes more prohibitive as the number of parallel channels increases. To solve this cost problem, a new 2-D exact moments recovery theory is proposed here that allows using signal coding as coarse as 1 bit without sacrificing accuracy. Therefore the cost of using a large parallel structure, and hence a fast multifrequency estimation scheme is no longer prohibitive. The simulation work carried out with some known filters substantiate very well this theory.
Fault-Tolerant Strassen-Like Matrix Multiplication (2020)

In this study, we propose a simple method for fault-tolerant Strassen-like matrix multiplications. The proposed method is based on using two distinct Strassen-like algorithms instead of replicating a given one. We have realized that using two different algorithms, new check relations arise resulting in more local computations. These local computations are found using computer aided search. To improve performance, special parity (extra) sub-matrix multiplications (PSMMs) are generated (two of them) at the expense of increasing communication/computation cost of the system. Our preliminary results demonstrate that the proposed method outperforms a Strassen-like algorithm with two copies and secures a very close performance to three copy version using only 2 PSMMs, reducing the total number of compute nodes by around 24% i.e., from 21 to 16.
Spinal Nociception is Facilitated during Cognitive Distraction (2022)

The nociceptive withdrawal reflex (NWR) is a behavioral response to protect the body from noxious stimuli. The spatial characteristics of the stimulus modulate the reflex response to prevent damage to the affected tissue. Interneurons in the deep dorsal horn in the spinal cord encode the relationship between stimulus characteristics and the magnitude of the NWR and are also likely integrating spatial information of the nociceptive stimulus. The aim of this study was to use the NWR to investigate whether the spinal spatial integration of a simultaneous stimulus is modulated by shifting the attention of the participant towards (attention) or away from (distraction) the stimulus. We hypothesized that the descending activity shapes the receptive fields of the spinal neurons encoding spatial integration of nociception. Twenty healthy volunteers participated in the study. Single and simultaneous stimuli were delivered through two stimulating electrodes located in the arch and on the lateral side in the sole of the foot. The NWR was quantified by electromyography from the Tibialis Anterior and Biceps Femoris muscles during baseline and active tasks (attention and distraction). During the baseline task, spatial summation of the NWR was evoked during simultaneous stimulation. During the distraction task, the NWR was significantly larger compared to baseline, regardless of the sites being stimulated (single and simultaneous stimuli). In contrast, the NWR recorded during the attention task did not differ from baseline. These results further support that the spinal NWR pathway is under descending control which can be modulated by cognitive processes. The NWRs recorded over both proximal and distal muscles were similarly affected by the tasks, suggesting that the descending control affects the lower leg spinal system, with no discrimination between spinal segments.