Calcium, Vitamin D, and Prevention of Colon Cancer (1991)

Introduction. Presenters and Planning Committee Members. CALCIUM AND VITAMIN D IN HUMAN NUTRITION. Calcium and Vitamin D in Human Nutrition (Robert P. Heaney, M.D., F.A.C.P.). Calcium Switches, Cell Cycles, Differentiation, and Death (James F. Whitfield, Ph.D.). EPIDEMIOLOGY: RELATIONSHIPS BETWEEN CALCIUM AND VITAMIN D INTAKE AND COLON CANCER. Colon Cancer Parallels Rickets (Cedric F. Garland, Dr.P.H., Frank C. Garland, Ph.D., and Edward D. Gorham, M.P.H.). Calcium and Colon Cancer in Los Angeles County (Ruth K. Peters, Sc.D., Thomas M. Mack, M.D., David H. Garabrant, M.D., David M. Homa, and Malcolm C. Pike, Ph.D.). Calcium and Colon Cancer in Utah (Martha L. Slattery, Ph.D., M.P.H., and Ann W. Sorenson, Ph.D.). BIOLOGY OF CALCIUM AND VITAMIN D AT THE CELLULAR AND TISSUE LEVEL. Colonic Hyperplasia and Hyperproliferation Induced in Rodents by a Nutritional Stress Diet Containing 4 Factors of the Western Human Diet: High Fat and Phosphate, Low Calcium and Vitamin D (H.L. Newmark, M.S. and M. Lipkin, M.D.). Use of Human Colonic Epithelial Cells in Tissue Culture to Study Mechanisms of Calcium Protection (Eileen A. Friedman, Ph.D.). Discussion of Presentation by Dr. Gary Stoner. ANIMAL STUDIES: PREVENTION OF COLON CANCER WITH CALCIUM AND VITAMIN D. The Inhibitory Effect of Calcium on Colorectal Cytokinetics and Carcinogenesis (R.C.N. Williamson, M.D., F.R.C.S., M.G. Thomas, Ch.M., F.R.C.S., and G.V.N. Appleton, Ch.M., F.R.C.S.). Calcium and Vitamin D Effects on Tumor Promotion in Rat Colon and Mouse Skin (Barbara C. Pence, Ph.D.). Effects of Bile Acids and Sterols on Animal Models of Colorectal Cancer (Bertram I. Cohen, Ph.D. and Erwin H. Mosbach, Ph.D.). Dietary Calcium, Phosphate and Vitamin D in Relation to Mammary Carcinogenesis (Kenneth K. Carroll, Ph.D., Lisa A. Eckel, H.B.S.C., Laurence J. Fraher, Ph.D., Jaroslav V. Frei, M.D., Ph.D., F.R.C.P. (c), and Harold Newmark, M.S.). Effect of Dietary Calcium on Azoxymethane-Induced Intestinal Carcinogenesis in Male F344 Rats Fed High-Fat Diets (Daniel J. Skrypec, Ph.D.). HUMAN STUDIES: POTENTIAL FOR PREVENTION OF COLON CANCER WITH CALCIUM AND VITAMIN D. Short-Term Calcium Intervention Studies, in Animals and Humans, Using Epithelial Proliferation as Biomarker of Response. The Initiation of a Calcium Intervention Trial in Adenoma Patients (Paul Rozen, M.D.). Calcium Effects in the Inhibition of the Initiation, Promotion, and Progression Phases of Colon Carcinogenesis and in Short-Term Trials in Humans (Michael J. Wargovich, Ph.D., Allan Baer, Ph.D., and Bernard Levin, M.D.). Patterns of Gene Expression Tthat Characterize Mucosa at Risk for Development of Colorectal Cancer (Leonard H. Augenlicht, Ph.D., Barbara Heerdt, Ph.D., Sharon Molinas, M.D., and Martin Lipkin, M.D.). Cytoarchitectural Response and Expression of c-fos/p52 Genes During Enhancement of Butyrate-Initiated Differentiation of Human Colon Carcinoma Cells by 1,25-Dihydroxyvitamin D3 and Its Analogs (Paul J. Higgins, Ph.D. and Yoko Tanaka, Ph.D.). Reproducibility of [3H]-Thymidine Labeling Index Determinations in Rectal Mucosal Crypt Organ Culture (D.S. Alberts, M.D., J.G. Einspahr, M.S., D.L. McGee, Ph.D., L.J. Hixson, M.D., J. Davidson, M.S., S. Emerson, Ph.D., and D.L. Earnest, M.D.). Effects of Dietary Calcium on Colorectal Cancer Risk in 2 High-Risk Groups: Postresection Cancer Patients and Familial Adenomatous Polyposis Patients (Hartley S. Stern, M.D., F.R.C.S.(C), F.A.C.S., and Hanoch Kashtan, M.D.). Effects of Calcium on Polyamine Metabolism and Proliferation in Colonocytes (Gordon D. Luk, M.D., Ph.D., and Freda L. Arlow, M.D.). Calcium Modulation of Intermediate Biomarkers in the Gastrointestinal Tract (Martin Lipkin, M.D.).