gebhart/patrepeval huggingface dataset:
Toward efficient power delivery using USB power delivery hub (2020)

Power delivery (PD) to computing and sensing devices in an indoor environment is as important as data communication between them. We are developing a USB-PD-based DC power supply system called VGHub. As the power loss at each input and output port of VGHub depends on the incoming or outgoing power at the port, the power distribution among all the ports needs to be optimized to maximize the power efficiency of VGHub. In this poster paper, we describe the formulation of a power distribution control in VGHub.
Delineation of Oil-Saturated Reservoir Zones Using Low Seismic Frequencies (2003)

P239 DELINEATION OF OIL-SATURATED RESERVOIR ZONES USING LOW SEISMIC FREQUENCIES 1 GENNADY M. GOLOSHUBIN 1 VALERI A. KORNEEV 2 VJACHESLAV M. VINGALOV 3 and VIACHESLAV KONSTANTINOV 4 1 University of Houston Houston Texas; USA 2 Lawrence Berkeley National Laboratory Berkeley California;USA Summary We consider the frequency dependence of seismic reflections from a thin (compared to the dominant wavelength) oil-saturated reservoirs. Reflections from permeable oil -saturated layer have increased amplitude and delayed travel time at low frequencies if compared with reflections from a nonpermeable layer. This effect was observed for seismic field data. One set of field data revealed high correlation
Intralesional Injection of Rose Bengal Induces a Systemic Tumor-Specific Immune Response in Murine Models of Melanoma and Breast Cancer (2013)

Intralesional (IL) injection of PV-10 has shown to induce regression of both injected and non-injected lesions in patients with melanoma. To determine an underlying immune mechanism, the murine B16 melanoma model and the MT-901 breast cancer model were utilized. In BALB/c mice bearing MT-901 breast cancer, injection of PV-10 led to regression of injected and untreated contralateral subcutaneous lesions. In a murine model of melanoma, B16 cells were injected into C57BL/6 mice to establish one subcutaneous tumor and multiple lung lesions. Treatment of the subcutaneous lesion with a single injection of IL PV-10 led to regression of the injected lesion as well as the distant B16 melanoma lung metastases. Anti-tumor immune responses were measured in splenocytes collected from mice treated with IL PBS or PV-10. Splenocytes isolated from tumor bearing mice treated with IL PV-10 demonstrated enhanced tumor-specific IFN-gamma production compared to splenocytes from PBS-treated mice in both models. In addition, a significant increase in lysis of B16 cells by T cells isolated after PV-10 treatment was observed. Transfer of T cells isolated from tumor-bearing mice treated with IL PV-10 led to tumor regression in mice bearing B16 melanoma. These studies establish that IL PV-10 therapy induces tumor-specific T cell-mediated immunity in multiple histologic subtypes and support the concept of combining IL PV10 with immunotherapy for advanced malignancies.
Molecular Characterization of a Hamster Viscerotropic Strain of Yellow Fever Virus (2002)

A hamster viscerotropic strain of yellow fever (YF) virus has been derived after serial passage of strain Asibi through hamsters. The parental Asibi/hamster p0 virus causes a mild and transient viremia in hamsters with no outward, clinical signs of illness. In contrast, the viscerotropic Asibi/hamster p7 virus causes a robust viremia, severe illness, and death in subadult hamsters. The genome of the hamster viscerotropic Asibi/hamster p7 virus has been sequenced and compared with the parental nonviscerotropic Asibi/hamster p0 virus identifying 14 nucleotide changes encoding only seven amino acid substitutions. The majority of these substitutions (five of seven) fall within the envelope (E) protein at positions Q27H, D28G, D155A, K323R, and K331R. These results support an important role for the E protein in determining YF virus viscerotropism.
Use case-driven specifications and technical re-quirements and initial channel model (2021)

This deliverable reports on the results of Task 1.1, providing an inventory of interactive use case specifications, representative deployment scenarios, technical requirements and KPIs for the four focus domains. D1.1 includes the initial channel model based on existing measurements and models. It reports on the particular investigation of the origin of latency in wireless applications.
Development of a novel Live Attenuated Influenza A Virus vaccine encoding the IgA-inducing protein (2021)

Live attenuated influenza virus (LAIV) vaccines elicit a combination of systemic and mucosal immunity by mimicking a natural infection. To further enhance protective mucosal responses, we incorporated the gene encoding the IgA-inducing protein (IGIP) into the LAIV genomes of the cold-adapted A/Leningrad/134/17/57 (H2N2) strain (caLen) and the experimental attenuated backbone A/turkey/Ohio/313053/04 (H3N2) (OH/04att). Incorporation of IGIP into the caLen background led to a virus that grew poorly in prototypical substrates. In contrast, IGIP in the OH/04att background (IGIP-H1att) virus grew to titers comparable to the isogenic backbone H1att (H1N1) without IGIP. IGIP-H1att- and H1caLen-vaccinated mice were protected against lethal challenge with a homologous virus. The IGIP-H1att vaccine generated robust serum HAI responses in na&amp;iuml;ve mice against the homologous virus, equal or better than those obtained with the H1caLen vaccine. Analyses of IgG and IgA responses using a protein microarray revealed qualitative differences in humoral and mucosal responses between vaccine groups. Overall, serum and bronchoalveolar lavage samples from the IGIP-H1att group showed trends towards increased stimulation of IgG and IgA responses compared to H1caLen samples. In summary, introduction of genes encoding immunomodulatory functions into a candidate LAIV that can serve as natural adjuvants to improve overall vaccine safety and efficacy.
Nut and Peanut Butter Consumption and Risk of Type 2 Diabetes in Women (2002)

Our findings suggest potential benefits of higher nut and peanut butter consumption in lowering risk of type 2 diabetes in women. To avoid increasing caloric intake, regular nut consumption can be recommended as a replacement for consumption of refined grain products or red or processed meats.
Loss of cytomegalovirus-specific immunological memory in a patient with thymoma (2002)

Cytomegalovirus (CMV) retinitis is a re-activation infection associated with severely impaired T cell-mediated immunity. We describe a patient with long-standing Crohn's disease and thymoma who developed severe CMV retinitis. While thymoma can be associated with impaired humoral immunity and a quantitative CD4+ T helper cell deficiency, these were not evident in our patient. However, more detailed investigation of anti-CMV responses showed absence of specific T cell responses to CMV antigen. Normal CMV seropositive controls have detectable proliferation and interferon-gamma production by T cells in response to stimulation with CMV antigen, but this was absent in this patient both during the acute infection and in convalescence. Other measures of T cell function were normal. Since CMV retinitis is due to reactivation of latent CMV infection, it appears that selective loss of CMV-specific immunity had occurred, perhaps secondary to a thymoma. The causes of thymoma-associated immune impairment are not understood, but this case demonstrates that selective defects can occur in the absence of global T cell impairment. Opportunistic infections should therefore be suspected in patients with thymoma even in the absence of quantitative immune deficiencies.
Street Tree Diversity in Three Northeastern U.S. States (2017)

Street tree diversity is widely viewed as a key component in the resilience of street tree populations to pests, diseases, and climate change. Assessment of street tree diversity is considered integral to sustainable street tree management and preservation of the ecosystem services and social benefits that street trees provide. This paper assesses street tree diversity in three northeastern U.S. states—New Jersey, New York, and Pennsylvania— by analyzing municipal street tree inventory data stratified by the 2012 USDA Plant Hardiness Zones. Despite the lesson learned from the historical devastation of overplanted American elms (Ulmus americana) by Dutch elm disease, and awareness of the contemporary threats posed to ashes (Fraxinus spp.) by the emerald ash borer (Agrilus planipennis) and to maples (Acer spp.), and other tree genera by the Asian longhorned beetle (Anoplophora glabripennis), results presented here indicate a current concentration of street trees among a relatively small number of species and genera, and in particular the dominance of maples as street trees. Results also show a positive relationship between street tree diversity and warmer average minimum winter temperatures. Consequently, there is a clear need in all three states for greater species and genus diversity in statewide and municipal street tree populations. However, meaningful impediments exist to increasing street tree diversity, especially in the short term.
All Organic Nanofibers As Ultralight Versatile Support for Triplet–Triplet Annihilation Upconversion (2013)

We present a method for the fabrication of ultralight upconverting mats consisting of rigid polymer nanofibers. The mats are prepared by simultaneously electrospinning an aqueous solution of a polymer with pronounced oxygen-barrier properties and functional nanocapsules containing a sensitizer/emitter couple optimized for triplet-triplet annihilation photon upconversion. The optical functionality of the nanocapsules is preserved during the electrospinning process. The nanofibers demonstrate efficient upconversion fluorescence centered at λ<sub>max</sub> = 550 nm under low intensity excitation with a continuous wave laser (λ = 635 nm, power = 5 mW). The pronounced oxygen-barrier property of the polymer matrix may efficiently prevent the oxygen penetration so upconversion fluorescence is registered in ambient atmosphere. The demonstrated method can be used for the production of upconverting ultralight porous coatings for sensors or upconverting membranes with freely variable thickness for solar cells.
The Return‐to‐Sport Clearance Continuum Is a Novel Approach Toward Return to Sport and Performance for the Professional Athlete (2022)

V, expert opinion.
The influence of drug distribution and drug-target binding on target occupancy: The rate-limiting step approximation (2017)

The influence of drug-target binding kinetics on target occupancy can be influenced by drug distribution and diffusion around the target, often referred to as "rebinding" or "diffusion-limited binding". This gives rise to a decreased decline of the drug-target complex concentration as a result of a locally higher drug concentration that arises around the target, which leads to prolonged target exposure to the drug. This phenomenon has been approximated by the steady-state approximation, assuming a steady-state concentration around the target. Recently, a rate-limiting step approximation of drug distribution and drug-target binding has been published. However, a comparison between both approaches has not been made so far. In this study, the rate-limiting step approximation has been rewritten into the same mathematical format as the steady-state approximation in order to compare the performance of both approaches for the investigation of the influence of drug-target binding kinetics on target occupancy. While both approximations clearly indicated the importance of k<sub>on</sub> and high target concentrations, it was shown that the rate-limiting step approximation is more accurate than the steady-state approximation, especially when dissociation is fast compared to association and distribution out of the binding compartment. It is therefore concluded that the new rate-limiting step approximation is to be preferred for assessing the influence of binding kinetics on local target site concentrations and target occupancy.
Heat-shock (H-S) and trabectedin efficacy in human soft-tissue sarcoma (STS) cells in vitro. (2013)

e13540 Background: Regional hyperthermia improves response and survival when combined with chemotherapy in patients with high-risk STSs (Issels, R.D. Lancet Oncol 2010). Trabectedin is the first marine-derived antineoplastic drug approved in Europe for the treatment of advanced STS after failure of anthracyclines and ifosfamide, or for patients who are unsuited to receive these drugs. Trabectedin’s cytotoxicity is associated with the induction of lethal DNA double-strand breaks (DSB). The rationale to combine trabectedin with H-S is that heat-exposure sensitizes tumor cells by inhibiting the repair of induced DSBs (Krawczyk, P.M. PNAS 2011). Methods: Combinations of trabectedin and H-S at clinically relevant temperatures were examined in 3 different human cell lines: Osteosarcoma (U2Os), liposarcoma (SW872) and synovial sarcoma (SW982). Cells were treated with trabectedin at the dose of 500-4000 pM for 3 hours. H-S was applied in an incubator at 41.8°C and 43°C for 90 or 150 min before, during or after trabectedin incubation. Cytotoxicity was assessed measuring clonogenic survival of cells. Expression of BRCA2, which recruits homologous recombination repair recombinase Rad 51 to DSBs, was measured by Western Blot (WB). Recruitment of Rad 51 and the amount of gH2AX positive DSB-repair-foci were analysed by immunocytochemistry (ICC). Results: All cell lines showed reduced viability after increasing doses of trabectedin at 37°C. Combined treatment with trabectedin and H-S additionally enhanced cytotoxicity of trabectedin with strongest effects observed after simultaneous administration of both. WB-analysis showed strong heat-dependent reduction of BRCA2 expression. ICC revealed that recruitment of Rad 51 to DSBs was reduced after heat exposure at 41.8°C and abolished after exposure at 43°C. Accordingly, combined treatment significantly increased the amount of cells with severe DNA damage (&gt;50 DSBs). Conclusions: Combined treatment with trabectedin and H-S in vitro resulted in significantly enhanced cytotoxicity that was accompanied by elevated DNA-damage in term of DSB-accumulation. The mechanisms of interaction between trabectedin and H-S concerning DNA repair are under investigation.
Membrane‐Surface Liquid Culture, Fungi (2009)

Abstract Filamentous fungi have been widely utilized in various fields of biotechnology for the production of fermented foods, organic acids, enzymes/proteins, pigments, antibiotics, and so on. Fungi are usually cultivated either by submerged liquid cultures, such as shake‐flask cultures (SFC) and cultures using an agitated vessel, or by solid‐substrate cultures (SSC) using natural agricultural products. Although fungi cultivated by SSC usually produce a much larger amount of enzymes and some secondary metabolites than those cultivated by submerged liquid cultures, SSC may have several problems/difficulties. To overcome the disadvantages of SSC, we developed a cultivation method called membrane‐surface liquid culture ( MSLC ). This article reviews the characteristics and principles of MSLC in comparison with conventional cultivation methods, apparatus/cultivation systems, and various experimental results.
Operando UV-Vis spectroscopy of a catalytic solid in a pilot-scale reactor: deactivation of a CrOx/Al2O3 propane dehydrogenation catalyst (2013)

A novel operando UV-Vis spectroscopic set-up has been constructed and tested for the investigation of catalyst bodies loaded in a pilot-scale reactor under relevant reaction conditions. Spatiotemporal insight into the formation and burning of coke deposits on an industrial CrO(x)/Al(2)O(3) catalyst during propane dehydrogenation has been obtained.
Enzymatic Synthesis and Organ Distribution Studies with13N-Labeled L-Glutamine and L-Glutamic Acid (1975)

A method was developed for producing several hundred mCi of 13NH3 with subsequent enzymatic synthesis of large amounts of 13N-labeled glutamine and glutamic acid. Dynamic measurements and quantitative whole body scans demonstrated greater glutamine uptake in the liver region of mongrel dogs than uptake of glutamic acid or NH3, although all concentrated in the liver to a significant degree. Myocardial uptake of glutamine and glutamic acid was low, while NH3 was incorporated into the heart, brain, bladder, and kidneys at a greater rate than the amino acids.
Low Hardware Complexity Filters for On-Chip Algorithm Used in Air Pollution Sensors for Dense Urban Areas in Smart Cities (2020)

The paper presents a method of transistor level implementation of a reconfigurable filter for the application in the algorithm responsible for processing air pollution data. The assumption of the proposed solutions is the realization of the algorithm that uses such filters directly in the wireless sensor, along with other components of such devices. Thanks to this, the amount of data exchanged between the sensors and the base station can be reduced. In the proposed filter structure, a special emphasis was placed on reducing the hardware complexity of the filter. The objective is to reduce the chip area of the overall device. The filter features a modular reconfigurable structure, which allows to achieve different filter orders, with almost linear increase in the hardware complexity. Target application of the proposed solution is in wireless sensors networks (WSN) that consist of large numbers of devices distributed, e.g. in dense urban areas in cities.
Analysis of the T-cell receptor beta-chainvariable-region (V beta) repertoire in monozygotic twins discordant for humanimmunodeficiency virus: evidence for perturbations of specific V beta segmentsin CD4+ T cells of the virus-positive twins. (1994)

We analyzed the T-cell receptor (TCR) V beta repertoire in human immunodeficiency virus type 1 (HIV-1)-infected individuals at different stages of disease. To circumvent the effect of HLA and other loci on the expressed TCR repertoire, we compared the TCR repertoire in nine pairs of monozygotic twins who were discordant for HIV infection. A semiquantitative polymerase chain reaction (PCR) assay and flow cytometry enabled us to show distinct differences in the V beta repertoire in the HIV-positive twin compared with the HIV-negative twin. By combining PCR and cytofluorometry, these differences were restricted to a specific set of TCR V beta segments, with members of the V beta 13 family perturbed in six out of seven cases and those of the V beta 21 family perturbed in four out of seven cases studied. Most of the other V beta families remained unchanged. Our results provide direct evidence for a skewed TCR repertoire in HIV infection.
Enzymatic Recycling of High-Value Phosphor Flame-Retardant Pigment and Glucose from Rayon Fibers (2017)

Viscose (also known as Rayon) filaments are obtained from regenerated cellulose and are used in many different sectors mainly as reinforcement material in tires and other cord applications and in the clothing industry. The incorporation of a phosphor-containing pigment imparts flame-retardancy properties to these fibers, which then can be used as part of personal protection textiles delivering wear comfort. There are no recycling strategies for these materials being brought to landfills or chemically degraded since incineration is difficult because of their flame retardancy. In this study, an enzyme-based strategy for the recovery of glucose and of the phosphor pigment without altering their chemical structures was developed as a circular economy solution. Rayon fibers were completely hydrolyzed by a cellulase preparation while 98% of the glucose (reducing sugar assay and HPLC analysis) and more than 99% of the flame-retardant pigment present in the fibers was recovered. The recovered pigment was analyzed via 1H, 13C, and 31P NMR, and the purity >95% was comparable to that of the commercially available pigment. The recovered glucose was successfully used as carbon source for ethanol production by Saccharomyces cerevisiae while the recycled phosphor pigment was reused in viscose filament production leading to similar mechanical properties like those measured for virgin fibers. This work presents an environmentally friendly recycling strategy of functional rayon fibers for the recovery of the two major components, namely, glucose and the pigment.
Furan Oxidation Reactions in the Total Synthesis of Natural Products (2018)

Recent developments on the transformations of furans under oxidative conditions toward the total synthesis of complex natural compounds are discussed. Reactions and methods are classified according to the type of oxidant used. Comparisons are then made between all the strategies to provide a comprehensive overview. This review covers the most prominent work published from 2011 until 2017. 1 Introduction 2 Reagents and Methods for Oxidation of the Furan Ring 2.1 Singlet Oxygen 2.2 Peroxides and Hydroperoxides 2.3 Quinones 2.4 Halogen-Based Oxidants 2.5 Chromium-Based Oxidants 3 The Achmatowicz Reaction 3.1 Halogen-Based Oxidants 3.2 Hydroperoxides 3.3 Enzymatic Oxidation 4 Conclusion
ChemInform Abstract: Development of a New Synthetic Route of a Non‐Peptide CCR5 Antagonist, TAK‐779, for Large‐Scale Preparation. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Letters. Atmospheric Mixing (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLetters. Atmospheric MixingWilliam. Viezee, Warren B. Johnson, and Hanwant B. SinghCite this: Environ. Sci. Technol. 1980, 14, 6, 628–631Publication Date (Print):June 1, 1980Publication History Published online15 April 2005Published inissue 1 June 1980https://pubs.acs.org/doi/10.1021/es60166a606https://doi.org/10.1021/es60166a606research-articleACS PublicationsRequest reuse permissionsArticle Views14Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts