gebhart/patrepeval huggingface dataset:
Reactions of DTPA Chelates of Iron, Zinc, Copper, and Manganese with Soils (1972)

Abstract The Fe, Zn, Cu, and Mn chelates and the Na salt of DTPA (diethylenetriaminepentaacetic acid) were reacted with suspensions of acid and alkaline soils. The suspensions were aerated and shaken continuously for periods of 2 hours to 30 days. The concentrations of soluble Fe, Zn, Cu, Mn, Ca, and Mg were measured by atomic absorption spectrophotometry, and the concentration of 14 C‐labeled DTPA was determined by a liquid scintillation technique. Additions of Fe‐DTPA were effective in maintaining soluble Fe in four soils ranging in pH from 5.8 to 7.3. Even at pH 7.9 more than 13% of added Fe remained soluble after 30 days of reaction in a calcareous soil. DTPA was an ineffective chelate for Zn and Cu in soils at pH 5.8 and 6.2, but became more effective with rising pH. In the alkaline soils more than 50% of added Zn and Cu remained soluble during 30 days of reaction. Essentially all Mn from Mn‐DTPA additions was lost from solution within 3 days in all soils. Discrepencies between the concentrations of 14 C‐labeled DTPA and soluble micronutrient metals suggest that an appreciable fraction of 14 C‐labeled DTPA decomposed to unknown products having different chelating capabilities.
Direct measurement of the inertial confinement time in a magnetically driven implosion (2017)

We report on direct, radiographic measurement of the stagnation phase of a magnetically driven liner implosion. The liner is filled with liquid deuterium and imploded to a minimum radius of 440 μm (radial convergence ratio of 7.7) over 300 ns, achieving a density of ≈10 g/cm3. The measured confinement time is ≈14 ns, compared to 16 ns from 1D simulations. A comparison of measured density profiles with 1D and 2D simulations shows a deviation in the reflected shock trajectory and the liner areal density. Additionally, the magneto Rayleigh-Taylor instability causes enhanced compression with shorter confinement in the bubble region compared to the spikes. These effects combine to reduce the pressure-confinement time product, Pτ, by 25% compared to the simulations.
MHC class II–dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies (2013)

Whether B cells serve as antigen-presenting cells (APCs) for activation of pathogenic T cells in the multiple sclerosis model experimental autoimmune encephalomyelitis (EAE) is unclear. To evaluate their role as APCs, we engineered mice selectively deficient in MHC II on B cells (B-MHC II(-/-)), and to distinguish this function from antibody production, we created transgenic (Tg) mice that express the myelin oligodendrocyte glycoprotein (MOG)-specific B cell receptor (BCR; IgH(MOG-mem)) but cannot secrete antibodies. B-MHC II(-/-) mice were resistant to EAE induced by recombinant human MOG (rhMOG), a T cell- and B cell-dependent autoantigen, and exhibited diminished Th1 and Th17 responses, suggesting a role for B cell APC function. In comparison, selective B cell IL-6 deficiency reduced EAE susceptibility and Th17 responses alone. Administration of MOG-specific antibodies only partially restored EAE susceptibility in B-MHC II(-/-) mice. In the absence of antibodies, IgH(MOG-mem) mice, but not mice expressing a BCR of irrelevant specificity, were fully susceptible to acute rhMOG-induced EAE, also demonstrating the importance of BCR specificity. Spontaneous opticospinal EAE and meningeal follicle-like structures were observed in IgH(MOG-mem) mice crossed with MOG-specific TCR Tg mice. Thus, B cells provide a critical cellular function in pathogenesis of central nervous system autoimmunity independent of their humoral involvement, findings which may be relevant to B cell-targeted therapies.
Endocrine therapy of human breast cancer cells: the role of secreted polypeptide growth factors. (1989)

Endocrine therapy is an important modality in the treatment of breast cancer. However, the precise molecular mechanisms underlying the growth inhibitory effect of endocrine therapy are unknown. Recently, it has been shown that breast cancer cells express and secrete polypeptide growth factors that can regulate the growth of the cells through autocrine and/or paracrine pathways. These growth factors are thought to be involved in the response to endocrine therapy. Three different mechanisms have been suggested: (1) stimulation of growth inhibitory peptides; (2) repression of mitogenic peptides; and (3) stimulation of mitogenic growth factors in cells overexpressing the corresponding receptor. This article reviews the scientific evidence on which these hypotheses are based.
Peak performance (2013)

Many database systems share a need for large amounts of fast storage. However, economies of scale limit the utility of extending a single machine with an arbitrary amount of memory. The recent broad availability of the zero-copy data transfer protocol RDMA over low-latency and high-throughput network connections such as InfiniBand prompts us to revisit the long-proposed usage of memory provided by remote machines. In this paper, we present a solution to make use of remote memory without manipulation of the operating system, and investigate the impact on database performance.
Surface Change and Ion Adsorption on Metal Oxides to 290 C (2001)

No abstract prepared.
Deep Learning with Gaussian Differential Privacy (2019)

Deep learning models are often trained on datasets that contain sensitive information such as individuals' shopping transactions, personal contacts, and medical records. An increasingly important line of work therefore has sought to train neural networks subject to privacy constraints that are specified by differential privacy or its divergence-based relaxations. These privacy definitions, however, have weaknesses in handling certain important primitives (composition and subsampling), thereby giving loose or complicated privacy analyses of training neural networks. In this paper, we consider a recently proposed privacy definition termed \textit{$f$-differential privacy} [18] for a refined privacy analysis of training neural networks. Leveraging the appealing properties of $f$-differential privacy in handling composition and subsampling, this paper derives analytically tractable expressions for the privacy guarantees of both stochastic gradient descent and Adam used in training deep neural networks, without the need of developing sophisticated techniques as [3] did. Our results demonstrate that the $f$-differential privacy framework allows for a new privacy analysis that improves on the prior analysis~[3], which in turn suggests tuning certain parameters of neural networks for a better prediction accuracy without violating the privacy budget. These theoretically derived improvements are confirmed by our experiments in a range of tasks in image classification, text classification, and recommender systems. Python code to calculate the privacy cost for these experiments is publicly available in the \texttt{TensorFlow Privacy} library.
Challenges and Opportunities in Developing Project Management Decision-Making Tools (2021)

Including sustainability criteria for making decisions in project management poses challenges in the areas of bioenergy, biotherapeutics, and biomaterials. This is mainly due to chemical heterogeneity of bio-based materials, techno-economic feasibility, and triple constraint of time, cost, and product quality. However, bio-based technologies create opportunities as sustainable processes because they involve upvaluation of locally available renewable and biodegradable materials. This work was conducted to identify challenges and opportunities in incorporating project management tools in bioproduct development with the goal of integrating measurable sustainability criteria scores in decision-making. The scores or metrics from these tools can be used by project managers for decision-making in engineering process scale-up, evaluation of social impact, and commercialization of processing technologies.
Edinburgh’s Syntax-Based Systems at WMT 2014 (2014)

This paper describes the string-to-tree systems built at the University of Edinburgh for the WMT 2014 shared translation task. We developed systems for English-German, Czech-English, French-English, German-English, Hindi-English, and Russian-English.
Cerebral Ischemia (2018)

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Boron-Lined Multitube Neutron Proportional Counter Test (2010)

Radiation portal monitors used for interdiction of illicit materials at borders include highly sensitive neutron detection systems. The main reason for having neutron detection capability is to detect fission neutrons from plutonium. The currently deployed radiation portal monitors (RPMs) from Ludlum and Science Applications International Corporation (SAIC) use neutron detectors based upon 3He-filled gas proportional counters, which are the most common large neutron detector. There is a declining supply of 3He in the world, and thus, methods to reduce the use of this gas in RPMs with minimal changes to the current system designs and sensitivity to cargo-borne neutrons are being investigated. Four technologies have been identified as being currently commercially available, potential alternative neutron detectors to replace the use of 3He in RPMs. These technologies are: 1) Boron trifluoride (BF3)-filled proportional counters, 2) Boron-lined proportional counters, 3) Lithium-loaded glass fibers, and 4) Coated non-scintillating plastic fibers. In addition, a few other companies have detector technologies that might be competitive in the near term as an alternative technology. Reported here are the results of tests of a boron-lined, “multitube” proportional counter manufactured by Centronic Ltd. (Surry, U.K. and Houston, TX). This testing measured the required performance for neutron detection efficiency and gamma-ray rejection capabilities of the detector.
An audio-haptic feedbacks for enhancing user experience in mobile devices (2013)

We introduce a haptic library that creates tactile feedback by analyzing audio data. Because the proposed haptic library uses audio signal of application to make tactile feedback, it doesn't need to modify application. Also, user can select a particular audio frequency band from multiple audio sources with haptic profiles; then only selected audio can be converted to the tactile feedback. We designed 4 haptic profiles for specific tactile effects. Finally, application examples of applying the haptic library were introduced.
Function of the MAPK scaffold protein, Ste5, requires a cryptic PH domain (2006)

Ste5, the prototypic mitogen-activated protein kinase (MAPK) scaffold protein, associates with plasma membrane-tethered Gbetagamma freed upon pheromone receptor occupancy, thereby initiating downstream signaling. We demonstrate that this interaction and membrane binding of an N-terminal amphipathic alpha-helix (PM motif) are not sufficient for Ste5 action. Rather, Ste5 contains a pleckstrin-homology (PH) domain (residues 388-518) that is essential for its membrane recruitment and function. Altering residues (R407S K411S) equivalent to those that mediate phosphoinositide binding in other PH domains abolishes Ste5 function. The isolated PH domain, but not a R407S K411S derivative, binds phosphoinositides in vitro. Ste5(R407S K411S) is expressed normally, retains Gbetagamma and Ste11 binding, and oligomerizes, yet is not recruited to the membrane in response to pheromone. Artificial membrane tethering of Ste5(R407S K411S) restores signaling. R407S K411S loss-of-function mutations abrogate the constitutive activity of gain-of-function Ste5 alleles, including one (P44L) that increases membrane affinity of the PM motif. Thus, the PH domain is essential for stable membrane recruitment of Ste5, and this association is critical for initiation of downstream signaling because it allows Ste5-bound Ste11 (MAPKKK) to be activated by membrane-bound Ste20 (MAPKKKK).
CD38 is expressed selectively during the activation of a subset of mature T cells with reduced proliferation but improved potential to produce cytokines (2004)

CD38 is an approximately 45-kDa type II transmembrane glycoprotein expressed by hematopoietic and nonhematopoietic cells. Its surface expression is under complex control and varies during lymphocyte development, activation, and differentiation, suggesting an important role in these processes. Murine CD38 has been mainly characterized on B lymphocytes, and in humans, the molecule has been studied in T cells. This paper provides evidences that murine CD38 is regulated tightly during T cell activation and differentiation. On the periphery, a subset of mature T lymphocytes was identified by the expression of CD38. These cells showed an activated phenotype; they were larger and more granular than their negative counterparts. In accord with this observation, in vitro-activated T cells up-regulated CD38. Memory T lymphocytes also were CD38-positive. It is interesting that T cells expressing high levels of CD38 had a reduced, proliferative capacity but displayed an improved potential to produce interleukin-2 and interferon-gamma, suggesting a role of this molecule during T cell activation and differentiation.
Observation of dissociative quasi-free electron attachment to nucleoside via excited anion radical in solution (2019)

Damage to DNA via dissociative electron attachment has been well-studied in both the gas and condensed phases; however, understanding this process in bulk solution at a fundamental level is still a challenge. Here, we use a picosecond pulse of a high energy electron beam to generate electrons in liquid diethylene glycol and observe the electron attachment dynamics to ribothymidine at different stages of electron relaxation. Our transient spectroscopic results reveal that the quasi-free electron with energy near the conduction band effectively attaches to ribothymidine leading to a new absorbing species that is characterized in the UV-visible region. This species exhibits a nearly concentration-independent decay with a time constant of ~350 ps. From time-resolved studies under different conditions, combined with data analysis and theoretical calculations, we assign this intermediate to an excited anion radical that undergoes N1-C1' glycosidic bond dissociation rather than relaxation to its ground state.
AMINO ACIDS, ARGINASE AND NITRIC OXIDE IN VASCULAR HEALTH (2006)

1. Nitric oxide (NO) plays a fundamental role in the vasculature because of its diverse influence in vascular protection, including its well-reported antiproliferative, anti-inflammatory, antithrombotic and vasodilator effects. In many vascular disease states, NO production is reduced as a result of endothelial dysfunction, in part caused by a decrease in substrate (L-arginine) availability. 2. The role of L-arginine and other amino acids important in nitrogen balance has been re-examined in the context of their effects on vascular health. The metabolism of L-arginine is complex because it is involved in a plethora of other pathways, such as urea, creatine and agmatine production. L-Arginine supplementation in patients with vascular disease is well reported to benefit patients therapeutically because of its effect on both NO-dependent and -independent mechanisms. 3. L-Arginine availability depends on the flux of other amino acids in the body, including L-glutamine, L-glutamate, L-ornithine, L-citrulline and L-lysine. The role of L-methionine and homocystine and their effect on NO also play an influential role in the body. 4. Recent data suggest that the key enzyme involved in the L-arginine-urea cycle, arginase, is coexpressed in NO-producing cells in the vasculature. In the present review, we examine the potential role of arginase as a therapeutic target for vascular health.
Increased activation product of complement 4 protein in plasma of individuals with schizophrenia (2021)

Structural variation in the complement 4 gene (C4) confers genetic risk for schizophrenia. The variation includes numbers of the increased C4A copy number, which predicts increased C4A mRNA expression. C4-anaphylatoxin (C4-ana) is a C4 protein fragment released upon C4 protein activation that has the potential to change the blood-brain barrier (BBB). We hypothesized that elevated plasma levels of C4-ana occur in individuals with schizophrenia (iSCZ). Blood was collected from 15 iSCZ with illness duration < 5 years and from 14 healthy controls (HC). Plasma C4-ana was measured by radioimmunoassay. Other complement activation products C3-ana, C5-ana, and terminal complement complex (TCC) were also measured. Digital-droplet PCR was used to determine C4 gene structural variation state. Recombinant C4-ana was added to primary brain endothelial cells (BEC) and permeability was measured in vitro. C4-ana concentration was elevated in plasma from iSCZ compared to HC (mean = 654 ± 16 ng/mL, 557 ± 94 respectively, p = 0.01). The patients also carried more copies of the C4AL gene and demonstrated a positive correlation between plasma C4-ana concentrations and C4A gene copy number. Furthermore, C4-ana increased the permeability of a monolayer of BEC in vitro. Our findings are consistent with a specific role for C4A protein in schizophrenia and raise the possibility that its activation product, C4-ana, increases BBB permeability. Exploratory analyses suggest the novel hypothesis that the relationship between C4-ana levels and C4A gene copy number could also be altered in iSCZ, suggesting an interaction with unknown genetic and/or environmental risk factors.
Small animal PET based on 16x16 TSV-MPPCs and monolithic crystals (2015)

In this work we present the design of a small animal PET based on 8 high-density arrays of MPPCs and monolithic scintillators. The MPPCs arrays are composed of 16x16 TSV-type (3x3 mm2) elements covering a rough active area of 5x5 cm2. A single LYSO block with a thickness of 10mm has been mounted on each detector. Black paint has been applied to the entrance and lateral faces of the crystal to preserve the scintillation light distribution. The axial and transaxial FOVs of one ring are 48 mm and 80 mm, respectively. Each MPPC array has been directly attached to a resistive readout circuit that provides outputs for each row and column of the array. These 32 signals are read with flexible boards 30 cm apart from the PET detector without any additional connectors in between. The PET-system is intended for in-line acquisition in front of MR scanners and as PET-insert inside the sensitive MRI volume. For this purpose, it is necessary to avoid magnetic sensible materials, such as nickel, and to prevent eddy currents in metallic structures induced by the MRI gradients. All detectors are air cooled and kept at temperatures of approximately 20oC with a variation below 0.05oC. The intrinsic resolution is 2.2 mm at the crystal center (averaged over all 2.6 mm) when Center of Gravity methods are used to resolve the impact position. This value is about a factor 1.5 better than results obtained with the H8500 PSPMT (64 PADs) and similar scintillators. With an improved collimator with holes with only 0.8mm diameter and a length of 70 mm, an intrinsic detector resolution of 1.1mm was reached. The energy resolutions of ROIs of 1x1 cm2 showed FWHM values in the range of 14%.
ChemInform Abstract: Molecular Rearrangements of (‐)‐α‐Cedrene in Superacids. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Atomic Force Microscopic Observation of in Vitro Polymerized Poly[(R)-3-hydroxybutyrate]: Insight into Possible Mechanism of Granule Formation (2005)

Atomic force microscopy (AFM) was used to study the formation and growth of poly[(R)-3-hydroxybutyrate] (PHB) structures formed in the enzymatic polymerization of (R)-3-hydroxybutyryl coenzyme A [(R)-3-HBCoA] in vitro. Poly(3-hydroxyalkanoate) (PHA) synthase (PhaC(Re)) from Ralstonia eutropha, a class I synthase, was purified by one-step purification and then used for in vitro reactions. Before the reaction, PhaC(Re) molecules were deposited on highly oriented pyrolytic graphite (HOPG) and observed as spherical particles with an average height of 2.7 +/- 0.6 nm and apparent width of 24 +/- 3 nm. AFM analysis during the initial stage of the reaction, that is, after a small amount of (R)-3-HBCoA had been consumed, showed that the enzyme molecules polymerize (R)-3-HBCoA and form flexible 3HB polymer chains that extend from the enzyme particles, resulting in the formation of an enzyme-nascent PHB conjugate. When a sufficient amount of (R)-3-HBCoA was used as substrate, the reaction rapidly increased after the first minute followed by a slow increase in rate, and substrate was completely consumed after 4 min. After 4 min, spherical granules continued to grow in size to form clusters over 10 um in width, and in later stages of cluster formation, the cluster developed small projections with a size of approximately 100-250 nm, suggesting qualitative changes of the PHB clusters. Moreover, the high-resolution AFM images suggested that globular structures of approximately 20-30 nm apparent width, which corresponds to the size of PhaC(Re), were located on the surface of the small PHB granule particles.
Optimising quasi-orthogonal STBC through group-constrained linear transformation (2007)

The generic algebraic structure of a quasi-orthogonal space-time block code (QO-STBC) has been derived, and group-constrained linear transformation (GCLT) as a mean to optimise the diversity and coding gains of a QO-STBC with square or rectangular QAM constellations has been proposed. Compared with QO-STBC with constellation rotation (CR), QO-STBC with GCLT requires only half the number of symbols for joint detection, hence lower maximum-likelihood decoding complexity. The optimum GCLT parameters for QO-STBC with square QAM constellation have been derived analytically. The optimised QO-STBCs with GCLT are able to achieve full-transmit diversity and have negligible performance loss compared with QO-STBCs with CR at the same code rate.
An Enhanced Lightweight Anonymous Authentication Scheme for a Scalable Localization Roaming Service in Wireless Sensor Networks (2016)

More security concerns and complicated requirements arise in wireless sensor networks than in wired networks, due to the vulnerability caused by their openness. To address this vulnerability, anonymous authentication is an essential security mechanism for preserving privacy and providing security. Over recent years, various anonymous authentication schemes have been proposed. Most of them reveal both strengths and weaknesses in terms of security and efficiency. Recently, Farash et al. proposed a lightweight anonymous authentication scheme in ubiquitous networks, which remedies the security faults of previous schemes. However, their scheme still suffers from certain weaknesses. In this paper, we prove that Farash et al.'s scheme fails to provide anonymity, authentication, or password replacement. In addition, we propose an enhanced scheme that provides efficiency, as well as anonymity and security. Considering the limited capability of sensor nodes, we utilize only low-cost functions, such as one-way hash functions and bit-wise exclusive-OR operations. The security and lightness of the proposed scheme mean that it can be applied to roaming service in localized domains of wireless sensor networks, to provide anonymous authentication of sensor nodes.