gebhart/patrepeval huggingface dataset:
Comparison between the Bacteriologic Flora of Different Segments of the Airways (1973)

Lower respiratory tract secretions uncontaminated with oropharyngeal flora were obtained from the main bronchi and the trachea by a bronchofiberscopic technic for bacteriologic evaluation and compared with cultures from the throat. The reliability of this method for providing selective lower airway specimens was confirmed by in vivo and in vitro testing. Of 38 elderly patients (68 ± 13 years) with respiratory tract infections and 14 patients (53 ± 20 years) with noninfectious lung disorders, 35 harbored pathogens in their lower airways. In only half were the same bacteria present both in the main bronchi and upper respiratory tract, indicating the somewhat limited diagnosic value of cultures from expectorated sputum or throat swabs in these patients. Bronchofiberscopy offers an innocuous bedside technic for the bacteriologic evaluation of the lower respiratory tract and appears to be preferable to the transtracheal aspiration method because it provides collection of a selective bronchial specimen, visualization of the bronchial mucosa and secretions, and tracheobronchial toilet in patients with retained secretions. Supported in part by General Research Support Grant, PHS grant No. FR-05622–01and a grant from the Leo Rosner Foundation. Presented in part at the annual meeting of the American Thoracic Society, May 21–24, 1972
P121Pulmonary valve atresia. Fetal echocardiography findings in one case with intact ventricular septum (2000)

Background Right ventricular outflow obstruction with an intact ventricular septum leads to severe hemodynamic problems in the newborn, with hypoxemia and congestive heart failure due to tricusp regurgitation. Atresia of the pulmonary valve occurs in less than 3% of all congenital heart lesions, with a frequency of 1:25 000 of live births. Use of fetal echocardiography permits prenatal diagnosis of this and other congenital defects, for a better knowledge and therapy. Case report 35‐year‐old pacient, with a previous newborn with an interventricular comunication. On her 30 week of pregnancy, a fetal echocardiography showed atresia of the pulmonary valve with an intact interventricular septum, severe tricuspid regurgitation, a right atrial dilatation, restriction of flow in the oval foramen of 8 m/seg and ductus arterioso with retrograde or bidirectional flow, from the aorta to the pulmonary circulation. Vaginal delivery occurred at 38 weeks, obtaining a female newborn, 2630 g, in good conditions. However she developed severe cardiac failure and died at day 4, in spite of pharmacologic with prostaglandins and surgical therapy. Conclusions Echocardiography is the basis of prenatal diagnosis of congenital heart disease, like pulmonary valve atresia, and is of great help to understand and decide the best perinatal therapy.
Serological Survey of Canine Distemper Virus Infection Using Enzyme-Linked Immunosorbent Assay. (1995)

For detection of antibodies against canine distemper virus (CDV), an enzyme-linked immunosorbent assay (ELISA) was developed using a crude extract from cells infected with the Onderstepoort strain of CDV as antigen. Twenty-six sera from dogs experimentally vaccinated with the Snyder-Hill strain of CDV were compared by ELISA and a standard virus neutralization (NV) test. Since a good correlation between the titers obtained by both tests was observed, ELISA was considered to be a rapid and reliable method for a serological survey of CDV infection. When a total of 167 sera from dogs suspected of canine distemper under natural conditions were examined by the ELISA, 29 of the sera (17%) were found to have low VN antibody titers and high ELISA titers. The reason for the discrepancy in the titers was discussed.
Communication optimization and code generation for distributed memory machines (1993)

This paper presents several algorithms to solve code generation and optimization problems specific to machines with distributed address spaces. Given a description of how the computation is to be partitioned across the processors in a machine, our algorithms produce an SPMD (single program multiple data) program to be run on each processor. Our compiler generated the necessary receive and send instructions, optimizes the communication by eliminating redundant communication and aggregating small messages into large messages, allocates space locally on each processor, and translates global data addresses to local addresses. Our techniques are based on an exact data-flow analysis on individual array element accesses. Unlike data dependence analysis, this analysis determines if two dynamic instances refer to the same value, and not just to the same location. Using this information, our compiler can handle more flexible data decompositions and find more opportunities for communication optimization than systems based on data dependence analysis. Our technique is based on a uniform framework, where data decompositions, computation decompositions and the data flow information are all represented as systems of linear inequalities. We show that the problems of communication code generation, local memory management, message aggregation and redundant data communication elimination can all be solved by projecting polyhedra represented by sets of inequalities onto lower dimensional spaces.
Effects of High-Dose Oral Vitamin A on Diarrheal Episodes among Children with Persistent Diarrhea in a Northeast Brazilian Community (1996)

The mean +/- SEM duration of diarrheal episodes decreased from 7.1 +/- 2.2 days to 4.3 +/- 0.9 days (P < 0.05) while the incidence of diarrheal episodes remained steady (2.2 +/- 0.3 versus 2.4 +/- 0.5 episodes; P = not significant) between two three-month periods before and after the oral administration of a single large age-adjusted dose of vitamin A among children at historical risk for persistent diarrhea in an impoverished Brazilian community.
PERSONALIZED HYPOTHESIS TESTS FOR DETECTING MEDICATION RESPONSE IN PARKINSON DISEASE PATIENTS USING iPHONE SENSOR DATA (2015)

We propose hypothesis tests for detecting dopaminergic medication response in Parkinson disease patients, using longitudinal sensor data collected by smartphones. The processed data is composed of multiple features extracted from active tapping tasks performed by the participant on a daily basis, before and after medication, over several months. Each extracted feature corresponds to a time series of measurements annotated according to whether the measurement was taken before or after the patient has taken his/her medication. Even though the data is longitudinal in nature, we show that simple hypothesis tests for detecting medication response, which ignore the serial correlation structure of the data, are still statistically valid, showing type I error rates at the nominal level. We propose two distinct personalized testing approaches. In the first, we combine multiple feature-specific tests into a single union-intersection test. In the second, we construct personalized classifiers of the before/after medication labels using all the extracted features of a given participant, and test the null hypothesis that the area under the receiver operating characteristic curve of the classifier is equal to 1/2. We compare the statistical power of the personalized classifier tests and personalized union-intersection tests in a simulation study, and illustrate the performance of the proposed tests using data from mPower Parkinsons disease study, recently launched as part of Apples ResearchKit mobile platform. Our results suggest that the personalized tests, which ignore the longitudinal aspect of the data, can perform well in real data analyses, suggesting they might be used as a sound baseline approach, to which more sophisticated methods can be compared to.
Expectation-Maximization Gaussian-Mixture Approximate Message Passing (2013)

When recovering a sparse signal from noisy compressive linear measurements, the distribution of the signal's non-zero coefficients can have a profound effect on recovery mean-squared error (MSE). If this distribution was a priori known, then one could use computationally efficient approximate message passing (AMP) techniques for nearly minimum MSE (MMSE) recovery. In practice, however, the distribution is unknown, motivating the use of robust algorithms like LASSO-which is nearly minimax optimal-at the cost of significantly larger MSE for non-least-favorable distributions. As an alternative, we propose an empirical-Bayesian technique that simultaneously learns the signal distribution while MMSE-recovering the signal-according to the learned distribution-using AMP. In particular, we model the non-zero distribution as a Gaussian mixture and learn its parameters through expectation maximization, using AMP to implement the expectation step. Numerical experiments on a wide range of signal classes confirm the state-of-the-art performance of our approach, in both reconstruction error and runtime, in the high-dimensional regime, for most (but not all) sensing operators.
Burns (1996)

This article describes the assessment and initial management of a patient with a burn injury. The article relates to UKCC professional development categories: Educational development and care enhancement.
Qualitative and quantitative analysis of FBN1 mRNA from 16 patients with Marfan Syndrome (2015)

Abnormal FBN1 transcripts were indicated in fibroblasts from patients with the splice site mutation c.4817-2delA and the missense mutation c.A4925G. While the mean FBN1 mRNA expression level in fibroblasts from patients with splice site and PTC mutations were lower than the mean level in patients with missense mutations and controls, inter-individual variability was high. The observation that high level of FBN1 mRNA in the patient with the missense mutation c.G2447T did not segregate with the mutation in the family suggests that variable expression of the normal FBN1 allele may contribute to explain the variability in FBN1 mRNA level.
Veterans at Brookhaven National Laboratory: In Service to Science (2016)

In service to science, veterans who served in our nation’s military and have embarked on new adventures at Brookhaven Lab help keep the Laboratory at the forefront of scientific discovery.
[Molecular pathogenesis of motor neuron disease]. (2001)

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that selectively involves motor neurons. About ninety percent of ALS patients are non-hereditary sporadic cases, the molecular pathogenesis of which is unknown. One of the effective approach to analyze the molecular pathology is to analyze the gene expression profiles of the neurons being involved in ALS and compare them to those of the intact neurons. The genes whose expression levels are specifically altered in ALS tissues are likely to be the candidate molecules which are related to the molecular pathogenesis of motor neuron degeneration. We have been examining the spinal cord tissues from the ALS and control autopsied cases by the methods of molecular indexing and cDNA microarray analysis. We have screened more than 10,000 genes, and obtained several novel genes the expression levels of which are altered in ALS tissues. We are now still ongoing to analyze the function of these genes as well as a role in pathophysiology in ALS.
The More Severe the Heart Disease, the Greater the Benefits of ICDs (2000)

Several recent studies have demonstrated that implantable cardioverter-defibrillators (ICDs) increase survival in patients with resuscitated
Snake Venomics and Antivenomics of the Arboreal Neotropical Pitvipers Bothriechis lateralis and Bothriechis schlegelii (2008)

We report the comparative proteomic characterization of the venoms of two related neotropical arboreal pitvipers from Costa Rica of the genus Bothriechis, B. lateralis (side-striped palm pit viper) and B. schlegelii (eyelash pit viper). The crude venoms were fractionated by reverse-phase HPLC, followed by analysis of each chromatographic fraction by SDS-PAGE, N-terminal sequencing, MALDI-TOF mass fingerprinting, and collision-induced dissociation tandem mass spectrometry of tryptic peptides. The venom proteomes of B. lateralis and B. schlegelii comprise similar number of distinct proteins belonging, respectively, to 8 and 7 protein families. The two Bothriechis venoms contain bradykinin-potentiating peptides (BPPs), and proteins from the phospholipase A 2 (PLA 2), serine proteinase, l-amino acid oxidase (LAO), cysteine-rich secretory protein (CRISP), and Zn (2+)-dependent metalloproteinase (SVMP) families, albeit each species exhibit different relative abundances. Each venom also contains unique components, for example, snake venom vascular endothelial growth factor (svVEGF) and C-type lectin-like molecules in B. lateralis, and Kazal-type serine proteinase inhibitor-like proteins in B. schlegelii. Using a similarity coefficient, we estimate that the similarity of the venom proteins between the two Bothriechis taxa may be <10%, indicating a high divergence in their venom compositions, in spite of the fact that both species have evolved to adapt to arboreal habits. The major toxin families of B. lateralis and B. schlegelii are SVMP (55% of the total venom proteins) and PLA 2 (44%), respectively. Their different venom toxin compositions provide clues for rationalizing the distinct signs of envenomation caused by B. schlegelii and B. lateralis. An antivenomic study of the immunoreactivity of the Instituto Clodomiro Picado (ICP) polyvalent antivenom toward Bothriechis venoms revealed that l-amino acid oxidase and SVMPs represent the major antigenic protein species in both venoms. Our results provide a ground for rationalizing the reported protection of the ICP polyvalent antivenom against the hemorrhagic, coagulant, defibrinating, caseinolytic and fibrin(ogen)olytic activities of Bothriechis ( schlegelii, lateralis) venoms. However, these analyses also evidenced the limited recognition capability of the polyvalent antivenom toward a number of Bothriechis venom components, predominantly BPPs, svVEGF, Kazal-type inhibitors, some PLA 2 proteins, some serine proteinases, and CRISP molecules.
Inestabilidades de ladera provocadas por el terremoto de Lorca de 2011 (Mw 5,1): comparación y revisión de estudios de peligrosidad de movimientos de ladera por efecto sísmicoen Murcia (2012)

La Cuenca de Lorca ha sido el objetivo de investigaciones recientes en las que se estudia el fenomeno de las
inestabilidades de ladera inducidas por terremotos y su evaluacion en el marco de diferentes escenarios sismicos,
teniendo en cuenta los efectos de amplificacion sismica debidos a la estratigrafia local y la topografia. Sin embargo, no ha sido hasta la ocurrencia de los terremotos del 11 de Mayo de 2011 en Lorca cuando ha sido posible realizar un analisis sistematico de este problema. En este articulo presentamos un inventario de 100 inestabilidades de ladera provocadas por los terremotos de Lorca, siendo principalmente desprendimientos de roca y suelo de pequeno tamano (1 a 100 m3). La distribucion de estos movimientos de ladera ha sido comparada con dos mapas de peligrosidad de inestabilidades: el primero, considerando la ocurrencia del
terremoto mas probable para un periodo de retorno de 475 anos en la Cuenca de Lorca (Mw = 5.0), publicado anteriormente a partir de un modelo digital de elevaciones (MDE) de baja resolucion; y un segundo, considerando
el caso real del terremoto de Lorca 2011 (Mw = 5.1) mediante el uso de un MDE de mucha mayor resolucion. Los desplazamientos de Newmark mas frecuentes relacionados con las inestabilidades provocadas por los terremotos de Lorca 2011 son menores de 2 cm en ambos escenarios de peligrosidad considerados, coincidiendo con zonas donde se han producido importantes efectos de amplificacion sismica (estratigrafica
y topografica).
RELATION BETWEEN THE FIRE PREVENTION POLICY AND DIFFUSION OF MUD-WALLED TOWNHOUSES IN NAGANO PREFECTURE (2010)

This study aims to explain the relation between the local fire prevention act and diffusion of mud-walled town houses in Nagano Prefecture. The act being put into operation in 1888 just after the great fire in Matsumoto city and lasted until 1890, referred to those of Tokyo in 1881 and Toyama in 1887, however contains its own elements. For example, it targeted only new buildings. In Matsumoto, one of the targeted cities among six, it is identified that mud-walled town houses were built after the local act in the burned district where few mud-walled houses existed before the fire.
Evaluation on thermocouples for the Thermal Time-of-Flight flow measurement (2009)

The authors report on a flow measurement technique using the Thermal Time-of-Flight (TTOF) method. In this work the velocity of air flowing through a pipe was investigated. For this purpose a filament and several thermocouples were adopted. The filament served as a signal transmitter, which injected thermal pulses into the flowing fluid in the pipe. The generated thermal pulses propagated along the flowing direction towards the thermocouples. In three defined distances the injected thermal pulses were detected by three identical thermocouples, respectively. The time behaviour of the measured output signals was computed using the crosscorrelation process. The time delay of the output signals combined with the knowledge of the distances resulted in the flow velocity. In this work, a flow measurement technique in the velocity range of vmin = 0.01 m/s up to vmax = 1.20 m/s is presented considering laminar flow.
Porphyrin containing isoindoline nitroxides as potential fluorescence sensors of free radicals (2011)

A series of new spin-labeled porphyrin containing isoindoline nitroxide moieties were synthesized and characterized as potential free radical fluorescence sensors. Fluorescence-suppression was observed in the free-base monoradical porphyrins, whilst the free-base biradical porphyrins exhibited highly suppressed fluorescence about three times greater than the monoradical porphyrins. The observed fluorescence-suppression was attributed to enhanced intersystem crossing resulting from electronexchange between the doublet nitroxide and the excited porphyrin fluorophore. Notably, fluorescencesuppression was not as strong in the related metalated porphyrins, possibly due to insufficient spin coupling between the nitroxide and the porphyrin. Continuous wave EPR spectroscopy of the diradical porphyrins in fluid solution suggests that the nitroxyl-nitroxyl interspin distance is long enough and tumbling is fast enough not to detect dipolar coupling.
Induction of Paneth cell degranulation by orally administered Toll‐like receptor ligands (2011)

The secretory activity of Paneth cells is related to the bacterial milieu in the small intestine; however, the molecules involved in inducing Paneth cell secretion of enzymes and antimicrobial peptides are not well-defined. Mice treated orally with CpG-oligodeoxynucleotide (ODN), an agonist of Toll-like receptor (TLR) 9, showed rapid and massive Paneth cell degranulation. CpG-ODN-induced degranulation was not observed in TLR9(-/-) mice or in chimeric TLR9(-/-) mice reconstituted with wild-type (WT) bone marrow, but was observed in WT mice reconstituted with TLR9(-/-) bone marrow, indicating a role for TLR9-expressing gastrointestinal cells in CpG recognition. The TLR3 agonist polyinosinic-polycytidylic acid also induced rapid degranulation, whereas the TLR4 and TLR5 agonists LPS and flagellin, respectively, induced late degranulation mediated by TNF-α. Our evidence that TLR9 and TLR3 agonists induce Paneth cell degranulation points to the need for further studies of the mechanisms underlying Paneth cell function as an avenue toward preventing infection and treating inflammatory bowel diseases.
The Tetraphenylester of the Imido-Dithiophoshoric Acid and is Palladium Complex - Crystal Structures. (1993)

The Tetraphenylester of the Imido-Dithiophoshoric Acid and is Palladium Complex - Crystal Structures.
Reductive coupling of alkynes to give ruthenium and osmium clusters of the type [M3(1,3-diene)(μ3-X)(CO)8] containing μ-η2,η2- or η4-1,3-diene (1999)

Replacement of a CO ligand by MeCN in the capped clusters [M3(µ-H)2(µ3-X)(CO)9] (M = Ru, X = NSO2C6H4Me-4 or M = Os, X = S) allows reductive coupling of alkynes (RCCH, R = H or Ph) to give regioselectively the 1,3-diene clusters [M3(C4H4R2)(µ3-X)(CO)8], with the diene µ-η2,η2-coordinated for ruthenium and η4 for osmium.
Mammalian GFRα-4, a Divergent Member of the GFRα Family of Coreceptors for Glial Cell Line-derived Neurotrophic Factor Family Ligands, Is a Receptor for the Neurotrophic Factor Persephin (2000)

Four members of the glial cell line-derived neurotrophic factor family have been identified (GDNF, neurturin, persephin, and enovin/artemin). They bind to a specific membrane-anchored GDNF family receptor as follows: GFRalpha-1 for GDNF, GFRalpha-2 for neurturin, GFRalpha-3 for enovin/artemin, and (chicken) GFRalpha-4 for persephin. Subsequent signaling occurs through activation of a common transmembrane tyrosine kinase, cRET. GFRalpha-4, the coreceptor for persephin, was previously identified in chicken only. We describe the cloning and characterization of a mammalian persephin receptor GFRalpha-4. The novel GFRalpha receptor is substantially different in sequence from all known GFRalphas, including chicken GFRalpha-4, and lacks the first cysteine-rich domain present in all previously characterized GFRalphas. At least two different GFRalpha-4 splice variants exist in rat tissues, differing at their respective COOH termini. GFRalpha-4 mRNA is expressed at low levels in different brain areas in the adult as well as in some peripheral tissues including testis and heart. Recombinant rat GFRalpha-4 variants were expressed in mammalian cells and shown to be at least partially secreted from the cells. Persephin binds specifically and with high affinity (K(D) = 6 nm) to the rat GFRalpha-4 receptor, but no cRET activation could be demonstrated. Although the newly characterized mammalian GFRalpha-4 receptor is structurally divergent from previously characterized GFRalpha family members, we suggest that it is a mammalian orthologue of the chicken persephin receptor. This discovery will allow a more detailed investigation of the biological targets of persephin action and its potential involvement in diseases of the nervous system.
Photochemistry of metal-metal bonded complexes. 5. Cleavage of the M-M bond in (OC)5M-M(CO)3L by irradiation into a low-lying M .fwdarw. L charge-transfer band (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotochemistry of metal-metal bonded complexes. 5. Cleavage of the M-M bond in (OC)5M-M(CO)3L by irradiation into a low-lying M .fwdarw. L charge-transfer bandDavid L. Morse and Mark S. WrightonCite this: J. Am. Chem. Soc. 1976, 98, 13, 3931–3934Publication Date (Print):June 1, 1976Publication History Published online1 May 2002Published inissue 1 June 1976https://pubs.acs.org/doi/10.1021/ja00429a032https://doi.org/10.1021/ja00429a032research-articleACS PublicationsRequest reuse permissionsArticle Views202Altmetric-Citations76LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts