gebhart/patrepeval huggingface dataset:
True histiocytic lymphoma following B‐acute lymphoblastic leukaemia: case report with evidence for a common clonal origin in both neoplasms (2001)

True histiocytic lymphoma (THL) is a very rare type of non-Hodgkin's lymphoma (NHL) in which neoplastic cells exhibit markers of histiocytic differentiation. Some cases of THL have been reported in patients with previous acute lymphoblastic leukaemia (ALL), especially in children and young adults, in whom the acute leukaemia was of T-cell origin. The relationship between the initial lymphoid tumour and the secondary THL remains unclear, as a common monoclonal origin shared by both neoplasms has never been definitively demonstrated. We report a patient with B-ALL who developed a nodal and extranodal tumour with histological and immunohistochemical features of THL 4 years after the initial diagnosis. Genotypic study showed that both neoplasms contained the same immunoglobulin heavy gene rearrangement, which has not been reported previously.
Miscibility of stereoregular poly(methyl methacrylates) with poly(styrene-co-p-(hexafluoro-2-hydroxy-2-propyl)styrene) (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMiscibility of stereoregular poly(methyl methacrylates) with poly(styrene-co-p-(hexafluoro-2-hydroxy-2-propyl)styrene)Dexin Luo, Eli M. Pearce, and T. K. KweiCite this: Macromolecules 1993, 26, 23, 6220–6225Publication Date (Print):November 1, 1993Publication History Published online1 May 2002Published inissue 1 November 1993https://pubs.acs.org/doi/10.1021/ma00075a015https://doi.org/10.1021/ma00075a015research-articleACS PublicationsRequest reuse permissionsArticle Views67Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Development of Clinical Standards for Flow Cytometry (1993)

Flow cytometers are instruments that can determine multiparameter data simultaneously and have a great potential in providing unique information about cells. To transfer this potential to the clinical laboratory, the development and the proper use of standards and calibrators are required to ensure comparability and reproducibility of data from different flow cytometers. Although there are a number of types of standards for flow cytometry, each has its specifically designed purpose to ensure that data from this complex instrument are accurate, precise, and reproducible among instruments over time.
Design of wireless sensor networks for building management (2003)

We provide a detailed study of the application of wireless sensor networks to a real-world building management system. A set of design requirements was discussed for the development of a sensor network architecture for an HVAC control system. We propose a system architecture that can be easily integrated into any existing building control system. We implemented a testbed to evaluate control strategies using ad hoc wireless sensors. The testbed was designed within the controlled environment chamber in the College of Environmental Design and UC Berkeley. Preliminary results from control strategies have allowed us to determine the effectiveness of the sensor network. The design of the system was suited for the kind of control applications that are indicative of the field. We discussed the lessons learned from our tests and propose future experiments with multiple ad hoc sensors to fully investigate the value added benefit of integrating this technology into the legacy architecture.
A randomized study of tucatinib (ONT-380) vs. placebo in combination with capecitabine and trastuzumab in patients with pretreated HER2-pos. metastatic breast cancer: HER2CLIMB (2018)

Treatment for HER2-pos. breast cancer patients after trastuzumab/pertuzumab and T-DM 1 isnot well examined, especially for those patients with brain metastases. Tucatinib (ONT-380) is a small molecule inhibitor of HER2 kinase. In a Phase 1b study, tucatinib was combined with capecitabine (C) and trastuzumab (Tz) in pts with HER2+ MBC previously treated with T-DM 1 and Tz. Objective responses were seen, including in pts with brain mets. The combination was well tolerated, with low rates of Gr 3 diarrhea at the recommended dose (300 mg PO BID). Therfore, tucatinib is now being evaluated in a study in combination with C and Tz (HER2CLIMB).
HTML5 Storage APIs (2011)

In the last chapter, we looked at creating a simple mobile web page and a simple Create Task form for our to-do list application. In this chapter, we will look at options for being able to store data locally on the device. HTML5 introduces a couple of APIs that permit this kind of client-side storage.KeywordsLocal StorageModule DefinitionPreceding CodeStorage InterfaceCurrent Date TimeThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Isolation of a recombinant antibody from cell culture supernatant: Continuous annular versus batch and expanded‐bed chromatography (2001)

Annular chromatography represents a crossflow approach to chromatographic separations, that allows the continuous separation of multicomponent mixtures. The potential of the method for continuous bioseparation has been discussed for some time, however, we demonstrate for the first time the processing of a complex feed (cell culture supernatant) taken from an actual (bio)process. Moreover, while previously published applications of annular chromatography concentrated on noninteractive (gel filtration) or nonspecific (ion exchange) chromatography, we show the possibility of continuous annular affinity chromatography. In particular, a commercially available preparative continuous annular chromatography (P-CAC) system was used to purify a recombinant antibody (human IgG(1)-kappa) from CHO cell culture supernatants by (pseudo)affinity chromatography on hydroxyapatite (HA) and rProtein A. Methods developed using small (2 mL) batch columns could be directly transferred to the P-CAC, where they yielded similar results in terms of final product quality. Yields were between 87% and 92% in the case of HA and between 77% and 82% in the case of rProtein A chromatography. DNA removal was nearly quantitative in all cases. Concomitantly, the antibody fraction of the total protein content was raised by one order of magnitude in HA and by a factor of 50 by rProtein A chromatography. In addition, a novel HA material (particle diameter -120 microm) was investigated, which was compatible with expanded-bed applications. However, the final purity of the antibody thus obtained and also the yields (<70%) were less than satisfactory.
A GTP-dependent step in the activation mechanism of capacitative calcium influx. (1993)

Calcium influx in electrically non-excitable cells is regulated by the filling state of intracellular calcium stores. Depletion of stores activates plasma membrane channels that are voltage-independent and highly selective for Ca2+ ions. We report here that the activation of plasma membrane Ca2+ currents induced by depletion of Ca2+ stores requires a diffusible cytosolic factor that washes out with time when dialyzing cells in the whole-cell configuration of the patch-clamp technique. The activation of calcium release-activated calcium current (ICRAC) by ionomycin- or inositol 1,4,5-trisphosphate-induced store depletion is blocked by guanosine 5'-3-O-(thio)triphosphate (GTP gamma S) and guanyl-5'-yl imidodiphosphate, non-hydrolyzable analogs of GTP, suggesting the involvement of a GTP-binding protein. The inhibition by GTP gamma S occurs at a step prior to the activation of ICRAC and is prevented by the addition of GTP. We conclude that the activation mechanism of depletion-induced Ca2+ influx encompasses a GTP-dependent step, possibly involving an as yet unidentified small GTP-binding protein.
Enhancing hyperspectral image quality using nonlinear PCA (2014)

In this paper, we propose a new method aiming at reducing the noise in hyperspectral images. It is based on the nonlinear generalization of Principal Component Analysis (NLPCA). The NLPCA is performed by an autoassociative neural network that have the hyperspectral image as input and is trained to reconstruct the same image at the output. Thanks to its bottleneck structure, the AANN forces the hyperspectral image to be projected in a lower dimensionality feature space where noise as well as both linear and nonlinear correlations between spectral bands are removed. This process permits to obtain enhancements in terms of hyperspectral image quality. Experiments are conducted on different real hyperspectral images, with different contexts and resolutions. The results are qualitatively and quantitatively discussed and demonstrate the interest of the proposed method as compared to traditional approaches.
The Demographics of Suspected Deep Tissue Injury in the United States (2010)

The survey data indicate that a decrease in overall prevalence of PrUs, as well as hospital-acquired PrUs, may have occurred in 2009. Suspected deep tissue injuries have become more commonly identified, which may be secondary to education of staging definitions.
Correction to: Comparison of biomass estimates from multiple stratification approaches in a swept area method for Pacific saury Cololabis saira in the western North Pacific (2021)

A correction to this paper has been published: https://doi.org/10.1007/s12562-021-01506-9
Formation Kinetics of Structure I Clathrates of Methane and Ethane Using an in Situ Particle Size Analyzer (2010)

Experimental data on the kinetics of structure I (sI) clathrate formation were obtained for pure methane and pure ethane in a semi-batch stirred-tank reactor that is equipped with an in situ particle size analyzer. The particle size analyzer used is a Lasentec focused beam reflectance measurement (FBRM) probe capable of measuring particle chord lengths between 0.5 and 100 μm. Experiments were conducted at temperatures ranging from 274 to 282 K and with pressures ranging from 0.99 to 7.25 MPa. A novel procedure for cleaning the FBRM probe tip, which eliminated the need to remove the probe between runs, was developed. Experimental data on the pressure, temperature, and particle size distribution were analyzed using the approach of Clarke and Bishnoi (Clarke, M. A.; Bishnoi, P. R. Determination of the intrinsic kinetics of CO2 gas hydrate formation using in situ particle size analysis. Chem. Eng. Sci. 2005, 60, 695−709), with minor modifications, and intrinsic rate constants were obtained for methane and ethane in sI.
Multi-Scale Modeling of Residual Stresses Evolution in Laser Powder Bed Fusion of Inconel 625 (2021)

Laser powder bed fusion exhibits many advantages for manufacturing complex geometries from hard to machine alloys such as IN625. However, a major drawback is the formation of high tensile residual stresses, and the complex relationship between the process parameters and the residual stresses has not been fully investigated. The current study presents multi-scale models to examine the variation of process parameters on melt pool dimensions, cyclic temperature evolutions, cooling rate, and cyclic stress generation and how they affect the stress end state. In addition, the effect of the same energy density, which is often overlooked, on the generated residual stresses is investigated. Multi-level validation is performed based on melt pool dimensions, temperature measurements with a two-color pyrometer, and finally, in-depth residual stress measurement. The results show that scan speed has the strongest effect on residual stresses, followed by laser power and hatch spacing. The results are explained in light of the non-linear temperature evolution, temperature gradient, and cooling rate during laser exposure, cooling time, and the rate during recoating time.
Investigation of lanthanum scintillators for 3D PET (2004)

The main thrust for this work is the investigation and design of a PET scanner based on new Lanthanum Halide scintillators. In 3-D PET the major limitations are scanner dead-time and ability to reject randoms and scatter. Therefore, to reach the full potential of 3-D PET requires a scintillator with good timing resolution and good energy resolution. The new Lanthanum Halide scintillators have very fast decay and very high light output which leads to timing resolution and energy resolution that are both superlative. For application to PET, we have constructed pixels with dimensions 4 /spl times/ 4 /spl times/ 30 mm/sup 3/, and have measured energy resolution of 5% (fwhm) at 511 kev and a timing resolution (fwhm) of 420ps, in coincidence with a plastic scintillator. An Anger-logic PET detector has been designed with pixels of these dimensions, coupled through a light-guide to an array of PMTs. Simulations have been performed which demonstrate very uniform energy resolution and very good pixel identification using 39 mm PMTs, although consideration will be given to larger 50 mm PMTs, as well. We have also simulated the timing resolution of this detector to be 440 ps, depending on the light-guide configuration. Using this detector as a basis of a new LaBr/sub 3/ PET scanner with 90 cm diameter and 25 cm axial extent, we predict a sensitivity of 1400 kcps//spl mu/Ci/cc and a peak NEC count-rate of 120 kcps using the NEMA NU2-2001 standard. The predicted NEC is higher than existing GSO and LSO-based scanners, which has been achieved by using a very high Energy Lower Level Discriminator (ELLD = 470 keV) to take full advantage of the excellent energy resolution of LaBr/sub 3/. The relative advantage of the LaBr/sub 3/ scanner is shown to increase for a phantom with larger diameter which better simulates a heavy patient. Further, the excellent timing resolution opens the possibility of measuring time-of-flight with sufficient accuracy to reduce the noise propagation during image reconstruction, thus leading to a significant gain in signal-to-noise. Assuming a timing resolution of 500 ps, we can expect the effective NEC to increase by a factor of 3 for a thin patient (20 cm diameter) and a factor 6 for a very heavy patient (40 cm diameter). Therefore, the combination of excellent energy resolution and timing resolution with LaBr/sub 3/ can potentially lead to a very significant improvement in PET performance.
Regioselective Dehydration of Sugar Thioacetals under Mild Conditions (2020)

Pentose and hexose sugars are abundant constituents of waste biomass, making them sustainable, chiral building blocks for organic synthesis. The demand for chiral saturated heterocyclic rings from the pharmaceutical industry is increasing as they provide well-defined three-dimensional frameworks that show increased metabolic resistance. Through the formation of thioacetals, sugars may be manipulated in their straight-chain form and dehydrated selectively under basic conditions at C-2. This approach was applied to an array of sugars and extended to the production of useful chiral THFs via further selective dehydration reactions.
Conducting Environmental Health Research in the Arabian Middle East: Lessons Learned and Opportunities (2012)

Cultural differences impact multiple aspects of epidemiologic research and should be respectfully addressed. Conducting international population-based environmental research poses many challenges; these challenges can be met successfully with careful planning, cultural knowledge, and flexibility. Lessons learned are applicable to interdisciplinary research all over the world. The research conducted will benefit the environmental and public health agencies of the UAE and provide the nation's leadership with country-specific environmental health data that can be used to protect the public's health in a rapidly changing environment.
Single crystals of Pb(Mg{sub 1/3}Nb{sub 2/3})O{sub 3}-35 mol% PbTiO from polycrystalline precursors (1998)

A potentially more cost-efficient method of growing single-crystal relaxor-based ferroelectric materials has been investigated. Seed single crystals of Pb(Mg{sub 1/3}Nb{sub 2/3})O{sub 3} (PMN)-35 mol% PbTiO{sub 3} (PT) were embedded within polycrystalline powders and annealed at temperatures from 900--1,200 C. The boundary of the single crystal migrated through the polycrystal matrix under the influence of grain boundary curvature; growth distances of several millimeters were observed, verifying the feasibility of the approach. The grown single crystals exhibited macroscopic cubic growth morphologies with (100) faces. Strain levels as high as 0.68% under an electric field of 30 kV/cm were observed in initial measurements.
Performance evaluation of electric distribution utilities based on data envelopment analysis (2003)

Summary form only given, as follows. In this paper, a method for benchmarking performance of electric distribution utilities based on data envelopment analysis (DEA) is presented. Basic theory of DEA is followed by case studies addressing performance analysis of 50 largest (based on MWh sales) electric distribution utilities In the USA. The results include performance efficiency, gaps in inputs and outputs of inefficient utilities, sensitivity based classification of utilities, and a gap report. Also, peer-to-peer comparison of inefficient with efficient utilities is provided. Based on these results inefficient utilities can develop strategic plans to improve performance.
Electrical characteristics of an ultrathin (1.6 nm) TaOxNy gate dielectric (2000)

This letter describes a process for the preparation of high-quality tantalum oxynitride (TaOxNy) via NH3 annealing of Ta2O5, for use in gate dielectric applications. Compared with tantalum oxide (Ta2O5), a significant improvement in the dielectric constant was obtained by the NH3 treatment. In addition, light reoxidation in a wet ambient at 450 °C resulted in a significantly reduced leakage current. We confirmed nitrogen incorporation in the tantalum oxynitride (TaOxNy) by Auger electron spectroscopy. By optimizing the nitridation and reoxidation processes, we obtained an equivalent oxide thickness as thin as 1.6 nm and a leakage current of less than 10 mA/cm2 at −1.5 V.
Risk of Non‐Hodgkin's Lymphoma in Primary Sjögren's Syndrome: A Population‐Based Study (2012)

The risk of NHL in patients with primary SS in Norway is increased 9 times compared with the general population. This is in accordance with recent studies, and the quality and completeness of the registries and strict use of diagnostic criteria support the validity of the results.
Kinetische Racematspaltung und Desymmetrisierung durch stereoselektive Silylierung von Alkoholen (2007)

Hab acht, asymmetrische Acylierung! Die nichtenzymatische kinetische Racematspaltung und Desymmetrisierung durch asymmetrische Acylierung von Alkoholen hat in der verwandten Silylierung einen Konkurrenten gefunden. Das Schema zeigt die Zweipunktanbindung des Substrats in der katalysator- (links) und reagenskontrollierten stereoselektiven Silylierung (rechts).
A high-performance LED array driver ASIC with programmable thermal coefficients (2002)

The authors describe the design of an LED driver ASIC for use in a high-performance printing system using advanced CMOS technology. This ASIC provides digitally controllable constant-current sources capable of delivering up to 6 mA to each channel of an array of 96 LEDs with an effective 16-bit resolution. It features automatic in-situ temperatures compensation with field programmable temperature coefficients that can be digitally varied from 0.3% to 2% per degree Kelvin. These current sources possess excellent current regulation in response to wide LED loading conditions, and are insensitive to power supply fluctuations. Fabricated using an advanced 1.5 mu m CMOS n-well, double-metal, single-poly process, it measures approximately 7.6 mm by 3.8 mm.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Neural Network Based Luminance Variation Resistant Remote-Photoplethysmography for Driver’s Heart Rate Monitoring (2019)

The driver's physiological status has enormous value to public traffic safety and cannot be ignored nowadays. In addition, heart rate (HR) is one of the most important indicators of human's health status. When detecting the driver's HR, using traditional contact-type devices might bring about the driver's distraction or discomfort. On the contrary, the remote photoplethysmography (rPPG) technique is a better way to monitor a driver's HR in vehicle applications simply by using a web-camera without interfering the driver. Most of the rPPG studies intended to reduce the interference caused by facial motion or luminance changes in the indoor or controlled scenario, but there are relatively fewer discussions on outdoor scenarios. Consequently, the purpose of this paper is to enhance the rPPG technique to make it suitable for the outdoor driving scenarios and for monitoring the driver's HR in different weather conditions, including daytime and nighttime. We first utilize artificial neural network (ANN) and train multiple personalized ANN models for each driver. For predicting the drivers' HR beat more precisely, we propose the approach, adaptive neural network model selection (ANNMS), which adaptively selects a personalized ANN model based on different noise conditions. Our algorithm eliminates the effect of noises caused by the variations of facial luminance in eight outdoor driving scenarios. The proposed driver's HR beat monitoring system has been evaluated against the state-of-the-art rPPG techniques that are Chrominance signal-based (CHRO) and k-nearest neighbors-based (kNN) algorithms. Compared with the CHRO and kNN algorithms, the ANNMS reduces the mean absolute error from 14.71 bpm (CHRO) and 9.91 (kNN) to 4.51 bpm (ANNMS) and enhances the success-rate-10, the probability in which the absolute error is below 10 bpm, from 44.1% (CHRO) and 56.3% (kNN) to 91.5% (ANNMS).
Probiotics, prebiotics, and the host microbiome: the science of translation (2013)

Recent advances in our understanding of the community structure and function of the human microbiome have implications for the potential role of probiotics and prebiotics in promoting human health. A group of experts recently met to review the latest advances in microbiota/microbiome research and discuss the implications for development of probiotics and prebiotics, primarily as they relate to effects mediated via the intestine. The goals of the meeting were to share recent advances in research on the microbiota, microbiome, probiotics, and prebiotics, and to discuss these findings in the contexts of regulatory barriers, evolving healthcare environments, and potential effects on a variety of health topics, including the development of obesity and diabetes; the long-term consequences of exposure to antibiotics early in life to the gastrointestinal (GI) microbiota; lactose intolerance; and the relationship between the GI microbiota and the central nervous system, with implications for depression, cognition, satiety, and mental health for people living in developed and developing countries. This report provides an overview of these discussions.