gebhart/patrepeval huggingface dataset:
Effect of supplements with lactic acid bacteria and oligofructose on the intestinal microflora during administration of cefpodoxime proxetil (2000)

Thirty healthy volunteers in three groups participated in a study of the effect on the intestinal microflora of oral supplementation with Bifidobacterium longum, Lactobacillus acidophilus and oligofructose, an indigestible oligosaccharide, during oral administration of cefpodoxime proxetil bd for 7 days. Those in group A also received an oral supplement with c.1011 cfu of B. longum BB 536 and L. acidophilus NCFB 1748 and 15 g oligofructose daily, those in group B received a supplement with oligofructose only and those in group C received placebo, for 21 days. In all three groups there was a marked decrease in aerobic microorganisms, involving mainly a rapid and almost complete disappearance of Escherichia coli (P: < 0.05) during antimicrobial administration and, thereafter, an overgrowth of enterococci (P: < 0.05). The number of intestinal yeasts also increased significantly (P: < 0.05) in groups A and B over the same period. There was a dramatic decrease in anaerobic microorganisms on day 4 of administration, mainly caused by loss of bifidobacteria (P: < 0.05) in all groups. The number of lactobacilli also decreased but was significantly higher in group A than in group C at the end of cefpodoxime proxetil administration. Clostridium difficile was found in only one person from group A, but six persons each in groups B and C. Of the bifidobacterial strains isolated from the faecal samples in group A, one was similar to the strain of B. longum administered, but most volunteers were colonized by several different strains of B. longum during the investigation period. The administered strain of L. acidophilus was recovered from six patients in group A.
Urinary Tract Infection (1991)

No AccessJournal of Urology1 Jul 1991Urinary Tract Infection Anthony J. SchaefferM.D. Anthony J. SchaefferAnthony J. Schaeffer More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)37764-9AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail © 1991 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 146Issue 1July 1991Page: 255-258 Advertisement Copyright & Permissions© 1991 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Anthony J. Schaeffer More articles by this author Expand All Advertisement PDF downloadLoading ...
Algorithm for minimum end-to-end delay paths (1997)

We consider the transmission of a message of size r from a source to a destination with the minimum end-to-end delay over a computer network where bandwidth can be reserved and guaranteed on the links. Different paths will be required for different intervals of values for r. We propose a polynomial-time algorithm that computes a table that maps all intervals for r to the corresponding paths that minimize the end-to-end delay.
High-Temperature Hall Effect Sensor Based on Epitaxial Graphene on High-Purity Semiinsulating 4H-SiC (2019)

In this report, we demonstrate a novel high-temperature Hall effect sensor that is based on quasi-free-standing monolayer graphene epitaxially grown on high-purity semiinsulating (SI) on-axis 4H-SiC(0001) substrate in a chemical vapor deposition process. To ensure statistical perspective, characteristics of 23 elements are determined as a function of temperature ranging from 300 to 770 K. Passivated with a 100-nm-thick atomic-layer-deposited aluminum oxide, the sensor offers current-mode sensitivity of 80 V/AT with thermal stability of -0.02%/K within the range between 300 and 573 K, and -0.06%/K between 573 and 770 K. The sensor's room-temperature output voltage is monitored in the magnetic field from -300 to +300 mT and its offset voltage at 0 T is assessed. Its high-temperature electrical properties are explained through a double-carrier transport involving spontaneous-polarization-induced holes in the graphene layer and thermally activated electrons emitted from a deep acceptor level related to silicon vacancy V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Si</sub> <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1-/2-</sup> occupying the k site of the 4H-SiC lattice. The sensor is compared with a previously reported one on vanadium-compensated SI on-axis 6H-SiC(0001). The new sensor's applicability to magnetic field detection at high temperatures is verified.
Zinc and Copper Ions Differentially Regulate Prion-Like Phase Separation Dynamics of Pan-Virus Nucleocapsid Biomolecular Condensates (2020)

Liquid-liquid phase separation (LLPS) is a rapidly growing research focus due to numerous demonstrations that many cellular proteins phase-separate to form biomolecular condensates (BMCs) that nucleate membraneless organelles (MLOs). A growing repertoire of mechanisms supporting BMC formation, composition, dynamics, and functions are becoming elucidated. BMCs are now appreciated as required for several steps of gene regulation, while their deregulation promotes pathological aggregates, such as stress granules (SGs) and insoluble irreversible plaques that are hallmarks of neurodegenerative diseases. Treatment of BMC-related diseases will greatly benefit from identification of therapeutics preventing pathological aggregates while sparing BMCs required for cellular functions. Numerous viruses that block SG assembly also utilize or engineer BMCs for their replication. While BMC formation first depends on prion-like disordered protein domains (PrLDs), metal ion-controlled RNA-binding domains (RBDs) also orchestrate their formation. Virus replication and viral genomic RNA (vRNA) packaging dynamics involving nucleocapsid (NC) proteins and their orthologs rely on Zinc (Zn) availability, while virus morphology and infectivity are negatively influenced by excess Copper (Cu). While virus infections modify physiological metal homeostasis towards an increased copper to zinc ratio (Cu/Zn), how and why they do this remains elusive. Following our recent finding that pan-retroviruses employ Zn for NC-mediated LLPS for virus assembly, we present a pan-virus bioinformatics and literature meta-analysis study identifying metal-based mechanisms linking virus-induced BMCs to neurodegenerative disease processes. We discover that conserved degree and placement of PrLDs juxtaposing metal-regulated RBDs are associated with disease-causing prion-like proteins and are common features of viral proteins responsible for virus capsid assembly and structure. Virus infections both modulate gene expression of metalloproteins and interfere with metal homeostasis, representing an additional virus strategy impeding physiological and cellular antiviral responses. Our analyses reveal that metal-coordinated virus NC protein PrLDs initiate LLPS that nucleate pan-virus assembly and contribute to their persistence as cell-free infectious aerosol droplets. Virus aerosol droplets and insoluble neurological disease aggregates should be eliminated by physiological or environmental metals that outcompete PrLD-bound metals. While environmental metals can control virus spreading via aerosol droplets, therapeutic interference with metals or metalloproteins represent additional attractive avenues against pan-virus infection and virus-exacerbated neurological diseases.
Notch Signaling Contributes to the Expression of Cardiac Markers in Human Circulating Progenitor Cells (2007)

It has been demonstrated that adult human circulating endothelial progenitor cells (EPCs) can differentiate to a cardiomyogenic phenotype. Notch signaling promotes epithelial-to-mesenchymal transformation and plays a role in heart and vessel development. Here, we investigated the role of Notch activation for cardiac differentiation of EPCs in a coculture system with neonatal cardiomyocyte. After coculture, Notch activation was transiently detected in EPCs, as determined by immunohistochemical detection of NICD (the intracellular cleavage fragment of Notch-1) and expression of human Notch target genes. Inhibition of gamma-secretase blocked Notch cleavage and NICD translocation. Furthermore, the expression of the cardiac marker protein alpha-sarcomeric actinin and troponin T was significantly suppressed by gamma-secretase inhibition or addition of soluble recombinant Jagged-1, indicating that Notch activation facilitates cardiac marker gene expression. Because noncanonical Wnts have previously been shown to promote cardiac differentiation, we additionally determined the influence of Notch activation on the expression of Wnt5a and Wnt11. Wnt5a and Wnt11 expression in the human cells was induced by the coculture and was blocked by gamma-secretase inhibition. Likewise, stimulation of Notch signaling by immobilized Jagged-1 promoted Wnt5a expression in EPCs. These data suggest that Notch is activated upon coculture of EPCs with neonatal rat cardiac myocytes. Gamma-secretase-dependent Notch activation is required for cardiac gene expression in human cells and induces the expression of noncanonical Wnt proteins, which may act in a paracrine manner to further amplify cardiac differentiation.
Assimilation of Synthetic GOES-R ABI Infrared Brightness Temperatures and WSR-88D Radar Observations in a High-Resolution OSSE (2016)

This study uses an observing system simulation experiment to explore the impact of assimilating GOES-R Advanced Baseline Imager (ABI) 6.95-μm brightness temperatures and Weather Surveillance Radar-1988 Doppler (WSR-88D) reflectivity and radial velocity observations in an ensemble data assimilation system. A high-resolution truth simulation was used to create synthetic radar and satellite observations of a severe weather event that occurred across the U.S. central plains on 4–5 June 2005. The experiment employs the Weather Research and Forecasting Model at 4-km horizontal grid spacing and the ensemble adjustment Kalman filter algorithm in the Data Assimilation Research Testbed system. The ability of GOES-R ABI brightness temperatures to improve the analysis and forecast accuracy when assimilated separately or simultaneously with Doppler radar reflectivity and radial velocity observations was assessed, along with the use of bias correction and different covariance localization radii for the brightness temperatures. Results show that the radar observations accurately capture the structure of a portion of the storm complex by the end of the assimilation period, but that more of the storms and atmospheric features are reproduced and the accuracy of the ensuing forecast improved when the brightness temperatures are also assimilated.
Waves and Phases (2007)

This chapter contains sections titled: Introduction Wave Phase Radius of Curvature Local Inclination and Divergence of a Complex Wave Conclusions
X-ray energy dependent photochemistry of the adamantane (C10H16)/Si(111)-7×7 surface (1993)

We have studied the synchrotron radiation (SR) induced photochemistry of the adamantane (C10H16) dosed Si(111)-7×7 surface using photoelectron spectroscopy. The adamantane/Si surfaces were characterized before and after they were exposed to broadband SR of varying energies and then annealed. When annealed to 525 K, the unexposed adamantane layers desorbed leaving only a layer of Si–H and hydrated Si–C species on the surface. When the adamantane adlayer was irradiated with broadband SR that contained energies greater than the C(1s) binding energy (284 eV), the surface reacted to form a layer similar to SiC. In contrast, when the surface was irradiated with broadband SR with energies below 284 eV, only the adamantane in direct contact with the Si surface dissociated. The remaining adamantane adlayer reacted with the surface in a manner which left the molecular structure of the reacted adamantane intact. The reacted adamantane layer was stable up to temperatures of at least 675 K.
Large number of periods in highly strained InGaAlAs/InGaAlAs MQW structures grown by metalorganic vapor-phase epitaxy (2003)

We have found that the crystalline quality at the well-barrier interfaces of an InGaAlAs strain-compensated MQW structure grown by MOVPE is much higher than that of an InGaAsP strain-compensated MQW structure, especially for a high strain. A large number of periods (25) in a highly strained (+1.4%) InGaAlAs MQW structure was obtained while preserving high crystalline quality by using the InGaAlAs strain-compensated structure.
Orbit Determination System for Low Earth Orbit Satellites (2007)

The IAI/MBT Precise Orbit Determination system for Low Earth Orbit satellites is presented. The system is based on GPS pesudorange and carrier phase measurements and implements the Reduced Dynamics method. The GPS measurements model, the dynamic model, and the least squares orbit determination are discussed. Results are shown for data from the CHAMP satellite and for simulated data from the ROKAR GPS receiver. In both cases the one sigma 3D position and velocity accuracy is about 0.2 m and 0.5 mm/sec respectively.
Estimation of Aircraft Engine Flight Mission Severity Caused by Erosion (2020)

Abstract More and more attention is being devoted to assessing severity of the engine operation for a high number of flights in a minimum of time. Compressor erosion is one of the physical phenomena contributing to this severity. Hence, an effective method is developed which allows a general judgment of the severity of engine operation with regards to compressor erosion. The shortening of the camber line at blade leading edge is selected as the parameter describing the degree of severity. The particle impingement conditions experienced by compressor blades throughout a flight mission are computed using a flight mission simulation and a non-dimensional engine model. Local flow conditions of all compressor blade rows are derived from mean line computations. A dimensional analysis of a straight through swirling annulus flow led to a simplified model of particle separation within the compressor blade rows. It turns out, that bypass ratio, bleed setting and degree of particle separation changing from operating point to operating point are significant drivers of erosion. Fan root and booster suffer less from compressor erosion than the high pressure compressor. The flight segments taxi, take-off, take-off climb, climb and cruise are significantly impacting the severity of a flight mission with regards to compressor erosion.
The Core Antigen of Hepatitis B Virus as a Carrier for Immunogenic Peptides (1999)

The core antigen of hepatitis B virus (HBcAg) made in Escherichia coli yields particles that closely resemble the viral nucleocapsid. Extensive modifications can be made to the primary structure of HBcAg without impairing particle assembly. This enables other peptide sequences, including very long sequences, to be added, substituted, or inserted into the nucleocapsid subunit while retaining the ability to form highly immunogenic particles. These also retain the T cell epitopes of HBcAg and constitute powerful delivery systems for a diverse range of immunogenic epitopes and have significant potential for development of multicomponent vaccines.
Atomic Collisions: Electron and Photon Projectiles (1991)

Fundamental concepts background information from the kinetic theory of gases collision theory: elastic scattering of electrons by neural atoms and molecules excitation and de-excitation of neutrals by electron impact ionization of neutrals by electron impact collisions of electrons with charged particles photon processes. Appendices: the distinction between a plasma and an ordinary ionized gas general references and sources of data.
Plant antitumour agents: alkaloids: synthesis of a pentacyclic camptothecin precursor (1970)

M. C. Wani, J. A. Kepler, J. B. Thompson, M. E. Wall and S. G. Levine, J. Chem. Soc. D, 1970, 404 DOI: 10.1039/C29700000404
The Use of Artificial Intelligence in Wireless Sports Sensors (2016)

The most profound technologies are those that disappear. They weave themselves into fabrics of everyday life until they are indistinguishable from it. This research work is a mere effort for automated decision making during sports of most common interest leveraging ubiquitous computing. Primarily cricket, football, hockey, athletics has been selected for the first implementation of the idea. A positioning system is used for locating the objects moving in the field can be found by blinking of light. Main objectives of the research are to help achieve the following goals. 1) Make decisions where human eye can make error due to human limitations. 2) Simulate the match activity during and after the game in a 3d computerized graphics system. 3) Make various types of game and performance analysis of a certain team or a player.
Holistic Resource Management (1988)

A companion to Holistic Resource Management, the Holistic Resource Management Workbook provides the practical instruction in financial, biological, and land planning necessary to apply the holistic management model. Allan Savory's teaching approach was developed and tested in classes for ranchers, farmers, and government agency personnel. Case studies drawn from real-life situations and presented in clear language lead the reader through the planning process.
A Multiallelic Molecular Beacon-Based Real-Time RT-PCR Assay for the Detection of SARS-CoV-2 (2021)

Emerging infectious viruses have led to global advances in the development of specific and sensitive detection techniques. Viruses have an inherent potential to easily mutate, presenting major hurdles for diagnostics and requiring methods capable of detecting genetically diverse viral strains. One such infectious agent is severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which emerged in December 2019 and has resulted in the global coronavirus disease 2019 (COVID-19) pandemic. This study presents a real-time reverse transcription PCR (RT-PCR) detection assay for SARS-CoV-2, taking into account its intrinsic polymorphic nature that arises due to genetic drift and recombination, as well as the possibility of continuous and multiple introductions of genetically nonidentical strains into the human population. This advance was achieved by using mismatch-tolerant molecular beacons designed to specifically detect the SARS-CoV-2 S, E, M, and N genes. These were applied to create a simple and reproducible real-time RT-PCR assay, which was validated using external quality control panels (QCMD: CVOP20, WHO: SARS-CoV-2-EQAP-01) and clinical samples. This assay was designed for high target detection accuracy and specificity and can also be readily adapted for the detection of other emerging and rapidly mutating pathogens.
A high-power, totally enclosed, permanent magnet, axial flux machine for engine integration (2010)

With the development of new forms of vehicle drive system and the interest of low fuel consumption, there is an increasing need for compact electrical machines that can be integrated with the IC engine to form compact power units. The paper will describe the design approach, development and testing of slotted totally enclosed permanent magnet axial flux machine and power electronics interface suitable for integration with an IC engine. The machine can be controlled to operate as a motor or generator over a wide speed range. Test results demonstrate that the electrical machine is capable of supplying a continuous rating of 42 kW, 200 Nm with efficiencies in the excess of 95% and a peak torque of 400 Nm. The combined efficiency of the DC/DC converter and the active rectifier is just over 96%. (6 pages)
INVESTIGATION OF THE TIRE/PAVEMENT INTERACTION MECHANISM: PHASE III FINAL REPORT. VOLUME 1: TIRE/PAVEMENT CONTACT FORCE MODELING (1987)

The interaction mechanism of heavy vehicle tires with road surface pavement is developed as a force, excitation, response problem. Results are presented in three volumes which report tire/pavement contact pressures, structural vibration response, and surface vibration acoustic modeling methods, respectively. The results of each report provide detailed information that may be utilized for tire/pavement evaluation by the methods developed in the subsequent reports. In this report, Volume 1, an efficient algorithm is derived and validated for the evaluation of road surface contact pressure, contact length, depth of tire penetration, and deformed tire geometry. A detailed description of pavement geometry and the tire inflation pressure are the only requirements for input to the analysis. The resulting pressure profile spectral energy is analyzed for correlation with noise spectra and pavement skid number. Results show that pavement textures characterized by dimensions of less than 10 mm (0.39 in.) act to reduce tire noise and to increase skid resistance. The texture-induced contact forces are combined with tread-induced forces to predict time-dependent contact pressures throughout the tire footprint.
Reconstruction of High-Resolution Tongue Volumes From MRI (2012)

Magnetic resonance images of the tongue have been used in both clinical studies and scientific research to reveal tongue structure. In order to extract different features of the tongue and its relation to the vocal tract, it is beneficial to acquire three orthogonal image volumes--e.g., axial, sagittal, and coronal volumes. In order to maintain both low noise and high visual detail and minimize the blurred effect due to involuntary motion artifacts, each set of images is acquired with an in-plane resolution that is much better than the through-plane resolution. As a result, any one dataset, by itself, is not ideal for automatic volumetric analyses such as segmentation, registration, and atlas building or even for visualization when oblique slices are required. This paper presents a method of superresolution volume reconstruction of the tongue that generates an isotropic image volume using the three orthogonal image volumes. The method uses preprocessing steps that include registration and intensity matching and a data combination approach with the edge-preserving property carried out by Markov random field optimization. The performance of the proposed method was demonstrated on 15 clinical datasets, preserving anatomical details and yielding superior results when compared with different reconstruction methods as visually and quantitatively assessed.
Transcriptional and post-transcriptional control mechanisms coordinate the onset of spermatid differentiation with meiosis I in Drosophila (1998)

The aly, can, mia and sa genes of Drosophila are essential in males both for the G2-meiosis I transition and for onset of spermatid differentiation. Function of all four genes is required for transcription in primary spermatocytes of a suite of spermatid differentiation genes. aly is also required for transcription of the cell cycle control genes cyclin B and twine in primary spermatocytes. In contrast can, mia and sa are required for accumulation of twine protein but not twine transcript. We propose that the can, mia and sa gene products act together or in a pathway to turn on transcription of spermatid differentiation genes, and that aly acts upstream of can, mia and sa to regulate spermatid differentiation. We also propose that control of translation or protein stability regulates entry into the first meiotic division. We suggest that a gene or genes transcribed under the control of can, mia and sa allow(s) accumulation of twine protein, thus coordinating meiotic division with onset of spermatid differentiation.
Supplementary methods from The Canonical Wnt Pathway Drives Macropinocytosis in Cancer (2023)

&lt;p&gt;Supplementary methods and legends for supplementary figures&lt;/p&gt;