gebhart/patrepeval huggingface dataset:
The effect of glucagon‐like peptide‐1 receptor agonists liraglutide and semaglutide on cardiovascular and renal outcomes across baseline blood pressure categories: Analysis of the LEADER and SUSTAIN 6 trials (2020)

It is unknown if the cardioprotective and renal effects of glucagon-like peptide-1 receptor agonists are consistent across blood pressure (BP) categories in patients with type 2 diabetes and at high risk of cardiovascular events. Using data from the LEADER (9340 patients) and SUSTAIN 6 (3297 patients) trials, we evaluated post hoc the cardiorenal effect of liraglutide and semaglutide on major adverse cardiovascular events (MACE) and nephropathy by baseline BP categories using a Cox proportional hazards model (treatment and subgroup as factors; adjusted for cardiorenal risk factors). Data from the two trials were analysed separately. In the LEADER and SUSTAIN 6 trials, the prevalence of stage 1 hypertension was 30% and 31%, respectively, and of stage 2 hypertension 41% and 43%, respectively. There was no statistical heterogeneity across the BP categories for the effects of liraglutide (P = .06 for MACE; P = .14 for nephropathy) or semaglutide (P = .40 for MACE; P = .27 for nephropathy) versus placebo. This implies that liraglutide and semaglutide may be beneficial for patients with type 2 diabetes, irrespective of their baseline BP.
Abstract A096: The potential role of fibroblast activation protein as a natural killer cell immune checkpoint (2019)

Abstract Fibroblast activation protein (FAP) is a type II transmembrane serine protease that functions as both a dipeptidyl peptidase and an endopeptidase. FAP is minimally expressed in normal pancreas but overexpressed in 90% of pancreatic ductal adenocarcinoma (PDAC) specimens. A meta-analysis of PDAC studies demonstrated elevated tumor FAP expression is associated with worse clinical outcomes. While immunotherapy offers remarkable results for certain cancer types, it has been largely ineffective in PDAC. This lack of efficacy may be attributed to the dense stromal fibrosis, comprised largely of pancreatic stellate cells (PSCs), that is characteristic of PDAC lesions. Here we demonstrate that human NK cell line (NK92) is activated by and kill PSCs. Upon direct contact with PSCs, NK92 cells upregulate FAP. FAP expression by NK92 cells is associated with an inactivation phenotype. Talabostat, a non-specific inhibitor of FAP, enhances NK92 killing of PSCs in vitro and enhances PDAC tumor clearance in vivo. This suggests that FAP may be a novel NK cell immune checkpoint that can be pharmacologically modulated to enhance NK cell antitumor activity. Citation Format: Allison O'Connell, Shangzi Wang, Louis M. Weiner. The potential role of fibroblast activation protein as a natural killer cell immune checkpoint [abstract]. In: Proceedings of the Fourth CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference: Translating Science into Survival; Sept 30-Oct 3, 2018; New York, NY. Philadelphia (PA): AACR; Cancer Immunol Res 2019;7(2 Suppl):Abstract nr A096.
Upstream Swirl Effects on the Flow Inside a Labyrinth Seal (1997)

The flow field inside a seven cavity tooth on rotor labyrinth seal was measured using a 3D laser Doppler anemometer system. The seal was operated at a Reynolds number of 24,000 and a Taylor number of 6,600 using water as the working fluid. Swirl vanes were placed upstream of the seal to produce positive, negative, and no preswirl. It was found that the axial and radial velocities were minimally effected. The tangential velocity, both in the clearance region and the seal cavities on the rotor, were greatly altered by the preswirl. By applying negative preswirl, the tangential velocity was suppressed, even in the seventh cavity. The turbulence levels decreased as the preswirl varied from negative to positive.
Energy Facilitated Na+ Uptake in Excised Corn Roots via 31P and 23Na NMR (1986)

The uptake of sodium ions by excised corn root tips (Zea mays L. cv FRB-73) was monitored by (23)Na nuclear magnetic resonance (NMR) methods in the presence of a membrane impermeable shift reagent under different metabolic conditions. In addition, for the first time, the energy status as well as the intracellular pH associated with this influx was concurrently evaluated by (31)P NMR. The rate of sodium ion uptake decreased (in order) as the normal metabolic state was changed by the addition of cyanide, anaerobic condition, and carbonyl cyanide trifluoromethoxy phenyl-hydrazone treatment. The results suggest that the proton electrochemical potential of the plasma membrane may facilitate the influx of Na(+).
Studies on the total synthesis of bouvardin and deoxybouvardin: cyclic hexapeptide cyclization studies and preparation of key partial structures (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies on the total synthesis of bouvardin and deoxybouvardin: cyclic hexapeptide cyclization studies and preparation of key partial structuresDale L. Boger and Daniel YohannesCite this: J. Org. Chem. 1988, 53, 3, 487–499Publication Date (Print):February 1, 1988Publication History Published online1 May 2002Published inissue 1 February 1988https://doi.org/10.1021/jo00238a005RIGHTS & PERMISSIONSArticle Views1670Altmetric-Citations43LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-Alerts Get e-Alerts
100 Mpixel/sec single-chip integrated graphics controller (IGC) (2002)

The IGC, a single-chip 2-D raster graphics engine for 1-2-Mpixel, 8-bit pseudorealistic color desktop systems, is described. With on-chip controllers for video, RAMDAC, and interleaved VRAMs, together with dedicated hardware for scan-conversion, image and block transfers, clipping, and raster operations, the 185 K transistor, 208-pin custom IC operates at 25 MHz at full 1-Mbit VRAM bandwidth of 100 Mpixel/s. The IGC eliminates the performance bottleneck of workstations and personal computers by performing graphics functions at the maximum bandwidth of the interleaved pixmap with a minimum amount of support hardware.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Expression, Purification, Crystallization and Preliminary X-ray Diffraction Analysis of the Mutant Pro(229)Ser of Thermostable Catechol 2,3-dioxygenase. (2001)

The mutant Pro(229)Ser of thermostable catechol 2,3-dioxygenase (TC23O) was expressed and purified. Enzymatic analysis revealed that its thermostability was decreased, the temperature corresponding to 50% enzyme activity being about 10.2 degrees lower than that of the wild type TC23O. Its kinetic parameter k(cat)/K(m) value (4.89x 10(6) mol(-1).s(-1)) was lower than that of the wild type TC23O(6.97x10(6) mol(-1).s(-1)). By the hanging-drop vapor-diffusion method using polyethylene glycol 400 as a precipitant, the mutant Pro(229)Ser of TC23O crystallizedat 4 degrees. X-ray diffraction analysis revealed that the crystals belong to the orthorhombic space group I(222) with unit-cell parameters a 7.059 nm, b 7.415 nm, c 13.311 nm, and they diffracted to at least 0.24 nm resolution. Assuming the presence of 2 molecules of the mutant Pro(229)Ser in the asymmetric unit, the Matthews parameter (Vm) was calculated to be 2.49x10( 3) nm(3).D(-1), and the solventcontent was about 51%. The crystal structure determination is now in progress.
3. Kapitel: Der subjektive Teil der Willenserklärung (2011)

Neben allem Wissenswerten aus dem BGB sowie dem Handels- und Gesellschaftsrecht werden auch die Grundzüge des Zivilprozess- und Insolvenzrechts behandelt.
MOF thin films: existing and future applications (2011)

The applications and potentials of thin film coatings of metal-organic frameworks (MOFs) supported on various substrates are discussed in this critical review. Because the demand for fabricating such porous coatings is rather obvious, in the past years several synthesis schemes have been developed for the preparation of thin porous MOF films. Interestingly, although this is an emerging field seeing a rapid development a number of different applications on MOF films were either already demonstrated or have been proposed. This review focuses on the fabrication of continuous, thin porous films, either supported on solid substrates or as free-standing membranes. The availability of such two-dimensional types of porous coatings opened the door for a number of new perspectives for functionalizing surfaces. Also for the porous materials themselves, the availability of a solid support to which the MOF-films are rigidly (in a mechanical sense) anchored provides access to applications not available for the typical MOF powders with particle sizes of a few μm. We will also address some of the potential and applications of thin films in different fields like luminescence, QCM-based sensors, optoelectronics, gas separation and catalysis. A separate chapter has been devoted to the delamination of MOF thin films and discusses the potential to use them as free-standing membranes or as nano-containers. The review also demonstrates the possibility of using MOF thin films as model systems for detailed studies on MOF-related phenomena, e.g. adsorption and diffusion of small molecules into MOFs as well as the formation mechanism of MOFs (101 references).
Intramolecular donor–acceptor cyclopropane ring-opening cyclizations (2013)

Cyclization reactions of donor-acceptor (D-A) cyclopropanes are recognized as versatile methods for construction of carbocyclic and heterocyclic scaffolds. In the literature, many examples of these polarized cyclopropanes' reactivity with nucleophiles, electrophiles, and radicals are prevalent. Although intermolecular reactivity of donor-acceptor cyclopropanes is widely reported, reviews that center on their intramolecular chemistry are rare. Thereupon, this tutorial review focalizes on new intramolecular transformations of donor-acceptor cyclopropanes for cycloisomerizations, formal cycloadditions, umpolung reactions, rearrangements and ring-opening lactonizations/lactamizations from 2009 to 2013. Furthermore, the role of D-A acceptor cyclopropanes as reactive subunits in natural product synthesis is underscored.
Correction: Corrigendum: CXCR2 deficient mice display macrophage-dependent exaggerated acute inflammatory responses (2017)

Scientific Reports 7: Article number: 42681; published online: 16 February 2017; updated: 10 April 2017. The original version of this Article contained a typographical error in the spelling of the author Laura Medina-Ruiz, which was incorrectly given as Laura Medina Ruiz. This has now been correctedin the PDF and HTML versions of the Article.
Absorption of Gamma Radiation as a Possible Mechanismfor Bigu: Theory and Data (2002)

The qigong state of bigu is believed to be supported by the absorption of qi from the universe. Gamma radiation is ubiquitous in the cosmos and, according to some, may be a possible source of energy for cellular functioning. When the concept of energy is integrated with the concept of dynamical systems, the logic leads to the theory—termed systemic memory—that predicts all systems, from the micro to macro, store information and energy to various degrees. New research indicates that the human body absorbs gamma radiation from the environment and emits high-frequency X rays. There are substantial individual differences in these effects that appear to be related, in part, to the psychological state of the person. Future research can determine if bigu is associated with increased absorption of gamma radiation and/or decreased emission of high frequency X rays. The hypothesis that qi can be viewed as quality information is proposed.
Relation of sputum inflammatory markers to symptoms and lung function changes in COPD exacerbations (2000)

Patients with more frequent exacerbations have higher baseline sputum cytokine levels, which may predict the frequency of future exacerbations.
Dislokationswahrscheinlichkeit verschiedener Elektrodenträger (2019)

Das Erreichen einer möglichst guten Sprachdiskrimination ist eine wesentliche Voraussetzung für erfolgreiche Teilhabe nach CI-Versorgung. Ein wichtiger Faktor ist die chirurgische Qualität, insbesondere das Vermeiden von Dislokationen, die Einbußen im Sprachverständnis nach sich ziehen.
Selective Preparation of Olefins through Conversion of C2 and C3 Alcohols on NASICON-Type Phosphates (2021)

We have studied the catalytic activity of LiZr2(PO4)3-based NASICON-type phosphates for conversion of C2 and C3 aliphatic alcohols with the aim of selectively preparing C2–C4 olefins. Selectivity has been controlled via partial heterovalent substitutions of In3+ or Nb5+ for Zr4+ or Mo for phosphorus. We have investigated the structure and morphology of the synthesized catalysts. The nature of the dopants has been shown to play a key role in determining the selectivity of the catalysts studied. Partial In3+ substitution for Zr4+ improves the dehydrogenating properties of the materials, whereas partial substitutions of Nb5+ for Zr4+ and Mo6+ for P5+ improve their dehydrating properties. We have demonstrated the possibility of highly selective preparation of ethylene and butylenes from ethanol and of propylene from propanol-1 and propanol-2.
Carrier proteins for fusion expression of antimicrobial peptides in Escherichia coli (2009)

Antimicrobial peptides are an essential component of innate immunity and play an important role in host defence against microbial pathogens. They have received increasing attention recently as potential novel pharmaceutical agents. To meet the requirement for necessary basic science studies and clinical trials, large quantities of these peptides are needed. In general, isolation from natural sources and chemical synthesis are not cost-effective. The relatively low cost and easy scale-up of the recombinant approach renders it the most attractive means for large-scale production of antimicrobial peptides. Among the many systems available for protein expression, Escherichia coli remains the most widely used host. Antimicrobial peptides produced in E. coli are often expressed as fusion proteins, which effectively masks these peptides' potential lethal effect towards the bacterial host and protects the peptides from proteolytic degradation. Although some carriers confer peptide solubility, others promote the formation of inclusion bodies. The present minireview considers the most commonly used carrier proteins for fusion expression of antimicrobial peptides in E. coli. The favourable properties of SUMO (small ubiquitin-related modifier) as a novel fusion partner are also discussed.
New double exposure technique without alternating phase-shift mask (2007)

The double exposure technique using alternating phase shift mask (alt-PSM) has been proposed and it is well used for the gate layer of the high performance logic devices as strong resolution enhancement technology (RET). This technique has advantage that the fine resist profile is obtained on wafer with extensive process margin. However, this double exposure technique is very expensive because of the alt-PSM cost. This time, the new double exposure technique without alt-PSM is developed for gate layer of 45 nm node logic devices. In this new double exposure method, attenuated phase shift mask (att-PSM) or binary mask (BIM) is used with dipole illumination. It is thought that this new double exposure method is effective for random logic devices which have various pattern pitches by the optimization of dipole illumination condition and pattern placement. Firstly, the optical contrast and depth of focus (DOF) is calculated. From these results, dipole illumination condition is optimized. It is found that DOF of new double exposure method is wider than that of conventional method. In addition, mask pattern is optimized to obtain wide process margin. For dense pattern, mask biasing is effective and optimization of shifter width is effective for isolated pattern. Furthermore, it is found that assist pattern is very effective for isolated pattern. From experimental results, it is proved that new double exposure method have wider process margin than that of conventional one. The strong design for manufacturing (DFM) rule that required the severe line width control is placed at single direction is proposed to realize the new double exposure method. Finally, it is found that the lithographic performance of new double exposure method has same level as conventional method with alt-PSM for gate layer of 45 nm logic devices.
Representation of HIV/Aids and Mental Health Co-Morbidity in Medical and Social Sciences Literature (2009)

Introduction: Aim of this article is to explore the ways in which, over the last 25 years, knowledge about HIV/Aids and Mental Health co-morbidity has been represented within medical and social sciences literature. Methods: The study has been conducted on the texts of 1101 published manuscripts abstracts within from 1984 to 2008, referring to 379 different journals and retrieved on PUBMED database. It was used the following database search string: ("mental health"[Title/Abstract]) or ("mental illness"[Title/Abstract]) AND (("aids"[Title/Abstract]) or ("hiv"[Title/Abstract]))). A Computer Aided Text Analysis was conducted with dedicated software: T-Lab (Lancia) using Cluster Analysis. Results: Cluster Analysis allowed to identify five different main dimensions: 1:(27,68%) Health-care Service organizational development; 2: (22,10%) Mental health as empowering precursor of infection risks. 3: (8,58%) Quality of life; 4: (19,17%). Therapies and treatments’ research; 5: (22,46%) Psychological issues, emotions and distress correlated to seropositive patients and their caregivers. Figure 1 it is a way to outline the five clusters literature trends over the time of 25 years. Conclusions: Our review could help to identify particular areas in need of change, to provide a baseline against which to assess future changes and to provide data for use in research health planning and policy analysis.
The variable membrane protein VmpA of Flavescence dorée phytoplasma interacts with cells of the insect vector Euscelidius variegatus (2017)

The variable membrane protein VmpA of Flavescence dorée phytoplasma interacts with cells of the insect vector [i]Euscelidius variegatus[/i]. 3. Hemipteran-Plant Interactions Symposium. HPIS 2017
ATMPKs: a gene family of plant MAP kinases in Arabidopsis thaliana (1993)

We previously reported two cDNAs for MAP kinases (cATMPK1 and cATMPK2) from a dicot plant, Arabidopsis thaliana. We describe here the cloning and characterization of five additional cDNAs encoding novel MAP kinases in Arabidopsis, cATMPK3, cATMPK4, cATMPK5, cATMPK6, and cATMPK7. The amino acid residues corresponding to the sites of phosphorylation (Thr-Glu-Tyr) that are involved in the activation of animal MAP kinases are conserved in all the seven putative ATMPK proteins. Genes for MAP kinases in Arabidopsis constitute a family that contains more than seven members. Sequence analysis suggests that there are at least three subfamilies in the family of Arabidopsis genes for MAP kinases.
Simulation Using ProModel (2000)

The second edition of Simulation Using ProModel covers the art and science of simulation in general and the use of ProModel simulation software in particular. The lead author is the Chief Technology Advisor for ProModel Corporation. The text is appropriate for use in both a graduate or undergraduate
Transfer of the Long Flexor Tendon of the Index Finger to the Proximal Phalanx of the Long Finger During Index-Ray Amputation (1971)

During the past three years the authors have used, in conjunction with indexray amputation, a tendon transfer of a flexor tendon of the index finger to the proximal phalanx of the long finger. A total of ten patients have undergone index-ray amputations combined with this transfer. In all but one patient the hand with the ray amputation maintained or increased strength in pulp-to-pulp or pulp-to-side pinch postoperatively. We continue to use this procedure and feel that it is a worth-while reconstructive procedure.
Proteomic investigation of the impact of oxygen on the protein profiles of hyaluronic acid‐producing Streptococcus zooepidemicus (2009)

Hyaluronic acid (HA) is a linear and negatively charged polysaccharide regularly used in medicine and cosmetics. Recently Streptococcus zooepidemicus has been exploited in the fermentation industry to produce HA. Many studies showed that higher amounts of HA were produced under aerobic condition compared to anaerobic conditions. To explore the effect of oxygen on the HA synthesis in S. zooepidemicus, 2-DE was used to compare the proteomes of aerobically and anaerobically fermented bacteria to identify proteins, which might be associated with the influence of oxygen on the HA synthesis. Totally nine pairs of 2-DE gels collected from three batches were compared and nine overexpressed proteins were observed in aerobically fermented bacteria. These proteins were identified by LC/tandem MS as dihydrolipoamide dehydrogenase, UDP-acetyl-glucosamine pyrophosphoylase, dihydrolipoamide-S-acetyltransferase and acetoin dehydrogenase alpha and beta chains, respectively. These upregulated proteins were involved in acetoin dissimilation, the central carbon metabolism and the HA anabolic pathway, implicating that oxygen might augment the expression of genes that are involved in central energy metabolism, acetoin reutilization and HA biosynthesis to enhance the amount of acetyl-CoA as such that more acetyl-CoA can be diverged from the central carbon metabolism to replenish acetyl-CoA for the HA synthesis.