gebhart/patrepeval huggingface dataset:
kinITC: A New Method for Obtaining Joint Thermodynamic and Kinetic Data by Isothermal Titration Calorimetry (2011)

Isothermal titration calorimetry (ITC) is the method of choice for obtaining thermodynamic data on a great variety of systems. Here we show that modern ITC apparatus and new processing methods allow researchers to obtain a complete kinetic description of systems more diverse than previously thought, ranging from simple ligand binding to complex RNA folding. We illustrate these new features with a simple case (HIV-1 reverse transcriptase/inhibitor interaction) and with the more complex case of the folding of a riboswitch triggered by the binding of its ligand. The originality of the new kinITC method lies in its ability to dissect, both thermodynamically and kinetically, the two components: primary ligand binding and subsequent RNA folding. We are not aware of another single method that can yield, in a simple way, such deep insight into a composite process. Our study also rationalizes common observations from daily ITC use.
A novel station online re-commssioning strategy for MMC-MTDC systems (2014)

A multi-terminal VSC-HVDC system based on the MMC technology (MMC-MTDC) has great application prospects for city center in-feed, grid connection and offshore wind energy integration because of its flexible power transmission. However, how to re-commission a converter station (after maintenance) online to the operating system without expensive dc Circuit Breakers(CBs) presents a huge challenge. By employing the structural characteristics of MMC, followed by certain sequential operations of the disconnectors (DSs) at dc side are proposed to implement the station online re-commissioning instead of using dc CBs. The charging process of a MMC station with a combination of ac and dc sources is studied firstly, and then a one-order circuit has been assumed to simplify the complicated charging process to get the potential maximum surge current and its decay constant. In order to decrease the surge current after closing the DSs at the positive and negative polarities separately, the valve should be blocked and the dc voltage of the operating system should be decreased properly. At last, the valve will be deblocked with increased dc voltage at the rated value. Besides easy operation, the strategy doesn't increase any cost. The simulation of a real three-terminal VSC-HVDC system, which is currently under construction in Shantou, China, has been performed in PSCAD/EMTDC to verify the strategy.
Time-Domain Gating Applied to the Quantitative Evaluation of Soft Defects in Embedded Electric Cables (2019)

The recent development of reflectometry-based methods for the diagnosis of embedded cables has highlighted the need for the full frequency characterization of soft faults. The purpose of this paper is to report for methods and laboratory experiments for deembedding the fixture effects of connectors in a defective embedded electrical line. It is shown how the two-window time-gating method can be applied to the diagnosis of real embedded electrical cables and its benefit concerning the quantitative estimation of the frequency signature of soft defects compared to the single-window gating technique. A new method is also introduced showing how, in such cases, the prior healthy line measurement can be approximated from the defective line measurement. The studied soft defects were partially unshielded coaxial cables.
Variable-Voltage Class-E Power Amplifiers (2007)

The class-E power amplifier is widely used due to its high efficiency, resulting from switching at zero voltage and zero slope of the switch voltage. In this paper, we extend general analytical solutions for the class-E power amplifier to the ideal single-ended variable-voltage class-E (class-E <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">VV</sub> ) power amplifier that switches at zero slope but not necessarily at zero voltage. The theory is verified by simulations and measurements, and show that the peak switch voltage of class-E <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">VV</sub> power amplifier is lower (up to ap 30% ) than in the conventional class-E power amplifier; which can be utilized to obtain e.g. higher output power (up to ap 200% more) with lower power-added efficiency (maximum ap 20% less) from technologies with low-breakdown voltages.
[Transcutaneous nephrolithotripsy in presenile and senile patients]. (2011)

A total of 323 transcutaneous roentgenoendoscopic operations were made in 212 patients from January 2000 to December 2009 including 96 operations in 81 presenile and senile patients (87 and 9 operations, respectively). Transcutaneous nephrolithotripsy (TCNT) eliminated concrement from the kidney for one session in 59 (72.8%) patients. It proved to be the most sparing treatment in serious clinical situations and provided maximally complete evacuation of the concrement from the kidney. A total complication rate was 14.8%. All the complications were cured with conservative pharmacotherapy. TCNT has the same indications as open surgery, is a method of choice in presenile and senile patients with large, stag-horn and recurrent concrements of the kidney, impacted pelvicoureteral concrements, in impaired renal urodynamics and high bacteriuria. TCNT can be used as a second-line treatment in failure of extracorporeal shock-wave lithotripsy or in combination with it (sandwich-therapy) for complete concrement elimination.
Supplementary Figure 4 from Glioblastoma-Derived Epidermal Growth Factor Receptor Carboxyl-Terminal Deletion Mutants Are Transforming and Are Sensitive to EGFR-Directed Therapies (2023)

&lt;p&gt;PDF file - 99K&lt;/p&gt;
Preparation and Characterization of Pressureless Sintered Alumina/5 vol % SiC Micro-Nanocomposites (2018)

Alumina/5 vol % SiC micro-nanocomposites were produced by slip-casting and pressureless sintering. The dispersion of alumina and SiC particles in water using an electrosteric dispersant was studied for different solid contents. Although the rheological and granulometry measurements showed that the optimum amount of Darvan C for well-dispersing 50 wt % dry matter slurries was 0.20 vol %, this content was increased to 1.00 vol % in order to avoid the demixing of SiC nanoparticles during shaping. Well densified (&gt;99%) alumina–SiC pressureless sintered materials were obtained at 1800 °C-2 h in which SiC nanoparticles occupied inter/intragranular positions. The creep behaviour of these materials was examined at 1200 °C under stresses ranging from 70 to 140 MPa. A good creep resistance in alumina-SiC materials was obtained demonstrating that the use of less expensive conventional sintering methods is possible and highlighting the importance of the dispersion step.
Development of a triplet magnetic lens system to focus a pulsed neutron beam (2010)

A triplet magnetic lens system composed of three sextupole-magnets and two spin flippers was constructed to focus pulsed neutrons in a wide wavelength range with same focal lengths. In this study, we performed a pulsed neutron beam focusing experiment with the system. The design of the system and the experimental results are shown and discussed.
The Prognosis of Children with Hydrocephalus and Congenital Heart Disease (2000)

The association of congenital hydrocephalus and heart disease in children is infrequent, but may present considerable dilemmas in management. This report describes the treatment and prognosis of 11 children with both clinical problems. There were 5 males and 6 females. Hydrocephalus occurred following aqueductal stenosis in 5 children and the Dandy-Walker malformation in 3. Three children were diagnosed with idiopathic hydrocephalus. Ten children underwent cerebrospinal fluid diversion procedures for control of hydrocephalus. Five children received pharmacological therapy for cardiac disease; 4 children required surgical correction. Two children died from medical conditions; 2 families declined treatment. Follow-up from 2 to 7 years in the remaining 7 children demonstrated moderate or severe neurodevelopmental disability in 5. One child at 2 years of age showed borderline developmental disability while 1 child is developing normally at 10 years of age. Overall the occurrence of symptomatic hydrocephalus and heart disease in the perinatal period resulted in mortality or neurodevelopmental disability in 9/11 children.
Polarographic and spectroscopic studies of the manganese(II), -(III), and -(IV) complexes formed by polyhydroxy ligands (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolarographic and spectroscopic studies of the manganese(II), -(III), and -(IV) complexes formed by polyhydroxy ligandsKeith D. Magers, Cecil G. Smith, and Donald T. SawyerCite this: Inorg. Chem. 1978, 17, 3, 515–523Publication Date (Print):March 1, 1978Publication History Published online1 May 2002Published inissue 1 March 1978https://doi.org/10.1021/ic50181a001RIGHTS & PERMISSIONSArticle Views365Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts Get e-Alerts
The effect of flipped learning on academic performance as an innovative method for overcoming ebbinghaus' forgetting curve (2018)

Recently, flipped learning has been attracting as an alternative teaching and learning method for university education. The purpose of this study is to propose flipped learning as an effective review method overcoming forgetting curve. This study is also aimed to provide empirical evidence for the effect of flipped learning in terms of both self-efficacy and academic performance. Three research questions guided the study: 1) Is there a difference in self-efficacy between traditional lecture style classroom and flipped classroom? ;2) Is there a difference in academic performance between traditional and flipped classroom? ; 3) If so, what is the main factor of the improvement? In this paper, a model of flipped learning supported by LMS is designed to allow students to practice 4 times of review methods while students follow the process of flipped learning of pre-, in- and post- class and reviewing as a self-directed learning.
Optical differentiator based on a trilayer metal-dielectric structure (2021)

Optical properties of a resonant trilayer metal-dielectric-metal (MDM) structure that consists of an upper metal layer, a dielectric layer, and a metal substrate are investigated. Using a multiple wave interference model, we prove that the reflection coefficient of the MDM structure may strictly vanish. The existence of a reflectance zero makes it possible to use the MDM structure as an optical differentiator. The numerical simulation results presented demonstrate the possibility of optical computation of the first derivative with respect to either time or spatial variable. The obtained results may find application in novel analog optical computing and optical information processing systems.
Multi-Mode Interferometry: Application to TiO2–SiO2 Sol-Gel Waveguide-Based Sensing in the Aerospace Domain (2021)

The optimization of a 2D optical sensor based on TiO2–SiO2 sol-gel waveguides for damage detection in the aerospace domain was performed in the framework of the ADD-ON European project. The sensor is based on the transportation of visible light along numerous waveguides, and damage is detected and localized through the monitoring of the output light from the waveguide grid. In this work, we have developed an architecture, inspired by a multi-mode interferometer (MMI), allowing us to efficiently multiply the number of waveguides that can be probed by a single optical source. For this, the beam propagation method (BPM) was used to model a rectangular MMI coupler (40 × 5624 µm2) operating in the visible region (600 nm), ensuring the propagation of light into three waveguides. The conceived device was then manufactured by UV photolithography (direct laser writing technique). The simulations and experimental results show that light transport into this architecture allows for the successful simultaneous probing of three waveguides. By complexifying the device structure, successful MMI couplers were easily manufactured, allowing us to probe 9, 15, or 45 TiO2–SiO2 waveguides with a unique light source. Finally, a further investigation regarding 24 consecutive thermal cycles from −40 °C to 60 °C, representative of the temperature changes during aircraft cruising, was performed. This study reveals that TiO2–SiO2 sol-gel waveguides are not mechanically damaged by temperature changes, while the light guidance remains unaffected, confirming that this sensor is very promising for aerospace applications. Since a single source can monitor several guides, the production of more compact, low-cost, and less intrusive sensors can be achieved by fulfilling structural health monitoring requirements.
[New findings on the ecology and epidemiology of murine herpes virus isolated in Slovakia]. (2000)

Rodents are important reservoir animals of many human microbial pathogens. Of small rodents, trapped on Slovakia territory, were several strains of murine herpes virus (MHV) isolated. Our purpose was to complete the existing knowledge about circulation of MHV in rodents and to find out, whether also other animal species including man are MHV sensitive or not. The presence of antibodies against MHV in serum of the tested animals and men was followed by virus neutralization test (VNT) and ELISA. Pathological changes in differential white blood cell count of the trapped rodents, were also observed because it is known, that MHV induces them in laboratory mice. A total of 627 small terrestrial mammals of nine species were collected in four localities of western and eastern Slovakia during 1984-1988. Neutralizing antibodies to MHV were detected in five species of rodents in 130 cases (20.7%). Antibodies were most frequently detected in Apodemus flavicollis (34.9%). Pathological changes in differential white blood cell count of trapped rodents were detected in 37% (34/92). Neutralizing antibodies were found also in serum of fallow deers (Dama dama), wild boars (Sus scrofa), deers (Cervus elaphus) and sheep but not in serum of pheasants (Phasianus colchicus) and muflons (Ovis musimon). ELISA and VNT tests were used to investigate 20 serums of employees of the Institute of Virology, Slovak Academy of Sciences and Faculty of Natural Sciences of Comenius University. There were eight samples positive (40%). The titers of antibodies were 4-32 in VNT and 1000 in ELISA.
Loss reduction of silicon-on-insulator waveguides for deep mid-infrared applications (2017)

We report that propagation loss of optical waveguides based on a silicon-on-insulator (SOI) material platform can be greatly reduced. Our simulations show that the loss, including SiO<sub>2</sub> absorption and substrate leakage, but no scattering loss, is 0.024 and 0.53 dB/cm in the deep mid-infrared at 4.8 and 7.1 μm wavelengths, where the material absorption in SiO<sub>2</sub> is 100 and 1000 dB/cm, respectively. The loss becomes negligible, compared to scattering loss in Si waveguides. This is enabled by using the TE<sub>10</sub> mode in a pedestal waveguide. We also show that the TE<sub>10</sub> mode can be excited in the proposed waveguide by the fundamental mode with a coupling efficiency of >94%. Low propagation loss, high coupling efficiency, and fabrication-friendly design would make it promising for practical use of SOI devices in the deep mid-infrared.
Portable Preimpact Fall Detector With Inertial Sensors (2008)

Falls and the resulting hip fractures in the elderly are a major health and economic problem. The goal of this study was to investigate the feasibility of a portable preimpact fall detector in detecting impending falls before the body impacts on the ground. It was hypothesized that a single sensor with the appropriate kinematics measurements and detection algorithms, located near the body center of gravity, would be able to distinguish an in-progress and unrecoverable fall from nonfalling activities. The apparatus was tested in an array of daily nonfall activities of young (n=10) and elderly (n=14) subjects, and simulated fall activities of young subjects. A threshold detection method was used with the magnitude of inertial frame vertical velocity as the main variable to separate the nonfall and fall activities. The algorithm was able to detect all fall events at least 70 ms before the impact. With the threshold adapted to each individual subject, all falls were detected successfully, and no false alarms occurred. This portable preimpact fall detection apparatus will lead to the development of a new generation inflatable hip pad for preventing fall-related hip fractures.
Patterns of Antibody Response to Severe Acute Respiratory Syndrome Coronavirus 2 Among 1.6 Million Blood Donors: Impact of Vaccination, United States, December 2020–June 2021 (2021)

From December 2020 to June 2021, 1654487 blood donors were tested for antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) S1 protein, and 1028547 (62.17%) were reactive. A rapid increase in prevalence was due to vaccination. Among a subset of 1567446 donors, 729771 (46.56%) reported SARS-CoV-2 vaccination, of whom 633769 (86.84%) were S1-antibody reactive only in response to vaccination and 68269 (9.35%) were reactive to both S1 and nucleocapsid in response to prior infection; the remainder were not reactive to either antibody. Among the 837675 (53.44%) donors who did not report vaccination, 210022 (25.07%) had reactivity to both antibodies and 29446 (3.52%) to S1 only.
Pre-operative serum vascular endothelial growth factor can select patients for adjuvant treatment after curative resection in colorectal cancer (2000)

We aim to determine the clinical usefulness of pre-operative serum vascular endothelial growth factor (VEGF) as a predictor of outcome in patients undergoing curative resection for colorectal cancer. Serum VEGF was assayed by quantitative ELISA in 81 patients prior to curative resection for node-negative (n = 53) and node-positive (n = 28) disease. Median follow-up for patients without cancer death was 27 months (range 21-37). Pre-operative serum VEGF was significantly higher in patients who went on to develop metastases than those who did not (median, 713 pg ml-1 vs. 314 pg ml-1, P < 0.0001). Using multivariate Cox regression analysis, pre-operative serum VEGF was the most important prognostic factor independent of nodal status and adjuvant chemotherapy, and was superior to nodal status in predicting outcome (P < 0.00001). At 575 pg ml-1, pre-operative serum VEGF was 64% sensitive and 89% specific in predicting the development of metastases in curative resections, with a positive predictive value of 73% and a negative predictive value of 85%. Pre-operative serum VEGF is a powerful predictor of outcome following curative surgery for colorectal cancer. These data support the measurement of pre-operative serum VEGF as a method for selecting patients who require adjuvant therapy.
Design, Processing and Properties of Monolith-Type Silicon-Transition Metal-Nitride Nanocomposites (2012)

International audience
Efficient collision checking in sampling-based motion planning via safety certificates (2016)

Collision checking is considered to be the most expensive computational bottleneck in sampling-based motion planning algorithms. We introduce a simple procedure that theoretically eliminates this bottleneck and significantly reduces collision-checking time in practice in several test scenarios. Whenever a point is collision checked in the normal (expensive) way, we store a lower bound on that point’s distance to the nearest obstacle. The latter is called a “safety certificate” and defines a region of the search space that is guaranteed to be collision-free. New points may forgo collision checking whenever they are located within a safety certificate of an old point. Testing the latter condition is accomplished during the nearest-neighbor search that is already part of most sampling-based motion planning algorithms. As more and more points are sampled, safety certificates asymptotically cover the search space and the amortized complexity of (normal, expensive) collision checking becomes negligible with respect to the overall runtime of sampling-based motion planning algorithms. Indeed, the expected fraction of points requiring a normal collision check approaches zero, in the limit, as the total number of points approaches infinity. A number of extensions to the basic idea are presented. Experiments with a number of proof-of-concept implementations demonstrate that using safety certificates can improve the performance of sampling-based motion planning algorithms in practice.
Fibrolamellar hepatocellular carcinoma: stage at presentation and results of aggressive surgical management. (1995)

Fibrolamellar carcinomas are often of advanced stage at diagnosis. Recurrence after resection with intent to cure is common. Early and frequent follow-up imaging is necessary for optimizing surgical management in patients with fibrolamellar carcinoma.
Telescope Considered As A Very High Gain Antenna (1989)

In the optical communications frame, the telescopes (emitter and receiver) are used as optical antennas they must have a high optical quality, low central obscuration, low straylight, low weight and low overall dimensions. We are studying, in the SILEX program, the telescope which is an afocal system composed of a Ritchey-Chretien telescope and a dioptric collimator. The parabolic primary mirror (250 mm diameter) is lightened to reduce weight. The mechanical concept is to join the periphery of the secondary mirror spider to the periphery of the primary mirror by a carbon fibers truss which permits high stability. The whole sets of supports are fixed on a sandwich base plate. Thermal environment and operating conditions lead to insure radiative uncoupling between mirrors, truss and outside of telescope and to use thermostated heaters on structural parts. The straylight, mainly due to the sun, can be limited by baffling systems and appropriate choice of materials (studied by MBB). As the telescope optical antenna gain depends on optical quality, optical transmission, obscuration and off-axis effects all these performances must be preserved during the whole flight. We present the study of this telescope whereas a breadboard manufacture and tests are in progress in BERTIN.