gebhart/patrepeval huggingface dataset:
EFFECT OF FEMORAL HEAD DIAMETER AND OPERATIVE APPROACH ON RISK OF DISLOCATION AFTER PRIMARY TOTAL HIP ARTHROPLASTY (2005)

Background: It has been postulated that use of a larger femoral head could reduce the risk of dislocation after total hip arthroplasty, but only limited clinical data have been presented as proof of this hypothesis. Methods: From 1969 to 1999, 21,047 primary total hip arthroplasties with varying femoral head sizes were performed at one institution. Patients routinely were followed at defined intervals and were specifically queried about dislocation. The operative approach was anterolateral in 9155 arthroplasties, posterolateral in 3646, and transtrochanteric in 8246. The femoral head diameter was 22 mm in 8691 of the procedures, 28 mm in 8797, and 32 mm in 3559. Results: One or more dislocations occurred in 868 of the 21,047 hips. The cumulative risk of first-time dislocation was 2.2% at one year, 3.0% at five years, 3.8% at ten years, and 6.0% at twenty years. The cumulative ten-year rate of dislocation was 3.1% following anterolateral approaches, 3.4% following transtrochanteric approaches, and 6.9% following posterolateral approaches. The cumulative ten-year rate of dislocation was 3.8% for 22-mm-diameter femoral heads, 3.0% for 28-mm heads, and 2.4% for 32-mm heads in hips treated with an anterolateral approach; 3.5% for 22-mm heads, 3.5% for 28-mm heads, and 2.8% for 32-mm heads in hips treated with a transtrochanteric approach; and 12.1% for 22-mm heads, 6.9% for 28-mm heads, and 3.8% for 32-mm heads in hips treated with a posterolateral approach. Multivariate analysis showed the relative risk of dislocation to be 1.7 for 22-mm compared with 32-mm heads and 1.3 for 28-mm compared with 32-mm heads. Conclusions: In total hip arthroplasty, a larger femoral head diameter was associated with a lower long-term cumulative risk of dislocation. The femoral head diameter had an effect in association with all operative approaches, but the effect was greatest in association with the posterolateral approach. Level of Evidence: Therapeutic Level III. See Instructions to Authors for a complete description of levels of evidence.
Interpenetrating Polymer Networks as a Route to Tunable Multi-responsive Biomaterials: Development of Novel Concepts (2009)

Novel concepts are proposed for interpenetrating polymer networks (IPNs) that can be used in biomaterials responsive to multiple types of environmental stimuli. The IPNs can be a route to the tunable biomaterials whose chemical structure and/or morphology can be adjusted to the type of task to be performed. The significance of utilizing new types of processes in polymer chemistry such as the Suzuki polycondensation and living/controlled radical polymerizations to the possibility of extending/modifying component networks in the IPNs and fine-tuning their properties is emphasized. Incorporation of nanofillers into IPNs and application of monomers other than traditional alkylacrylamides as a way to enhance versatility of IPNs are also considered.
Herpes Virus Fusion and Entry: A Story with Many Characters (2012)

Herpesviridae comprise a large family of enveloped DNA viruses all of whom employ orthologs of the same three glycoproteins, gB, gH and gL. Additionally, herpesviruses often employ accessory proteins to bind receptors and/or bind the heterodimer gH/gL or even to determine cell tropism. Sorting out how these proteins function has been resolved to a large extent by structural biology coupled with supporting biochemical and biologic evidence. Together with the G protein of vesicular stomatitis virus, gB is a charter member of the Class III fusion proteins. Unlike VSV G, gB only functions when partnered with gH/gL. However, gH/gL does not resemble any known viral fusion protein and there is evidence that its function is to upregulate the fusogenic activity of gB. In the case of herpes simplex virus, gH/gL itself is upregulated into an active state by the conformational change that occurs when gD, the receptor binding protein, binds one of its receptors. In this review we focus primarily on prototypes of the three subfamilies of herpesviruses. We will present our model for how herpes simplex virus (HSV) regulates fusion in series of highly regulated steps. Our model highlights what is known and also provides a framework to address mechanistic questions about fusion by HSV and herpesviruses in general.
Protein phosphatases 1, 2A, and 2C are protein histidine phosphatases. (1993)

Eukaryotic cellular proteins contain phosphohistidine. To search for protein histidine phosphatases, protein histidine kinase from Saccharomyces cerevisiae was used to phosphorylate histone H4 on histidine at position 75 in the H4 amino acid sequence. Incubation of the phosphorylated histone H4 with either protein phosphatase 1, 2A, or 2C resulted in extensive removal of phosphate from the phosphorylated histone. Thus, protein phosphatases 1, 2A, and 2C are histidine phosphatases as well as serine/threonine phosphatases. Calcium/calmodulin-regulated protein phosphatase (protein phosphatase 2B) did not remove phosphate from phosphohistidine. The histidine phosphatase reaction was tested for a magnesium requirement and effects of inhibitor-1 and okadaic acid. In all cases, the protein phosphatases behaved as they do in their serine/threonine phosphatase activity. Extracts of the yeast, S. cerevisiae, contain protein histidine phosphatase activity. Quantitative measurement of phosphatase activity shows that the activity against phosphohistidine is a major activity of protein phosphatases 1, 2A, and 2C.
Effect of serum on ganglioside uptake and choleragen responsiveness of transformed mouse fibroblasts (1978)

NCTC 2071 cells, transformed mouse fibroblasts, did not respond to choleragen when grown in chemically defined medium. When grown in medium containing 10 percent fetal calf serum, however, the cells accumulated cyclic AMP upon exposure to the toxin. Gangliosides isolated from the fetal calf serum were as effective as whole serum in inducing choleragen responsiveness in the cells. The putative choleragen receptor, the monosialo-ganglioside GM1, could not be detected by chemical analysis in cells exposed to serum. 3H-Labeled GM1 was detected in these cells, however, following sequential exposure to galactose oxidase and sodium borotritide. Thus, uptake of minute amounts of GM1 from serum by these cells sensitized them to choleragen.
A Two-Tiered Grammatical Approach for Agent-based Computational Design (2018)

Early stages of the engineering design process are vital to shaping the final design; each subsequent step builds from the initial concept. Innovation-driven engineering problems require designers to focus heavily on early-stage design generation, with constant application and evaluation of design changes. Strategies to reduce the amount of time and effort designers spend in this phase could improve the efficiency of the design process as a whole. This paper seeks to create and demonstrate a two-tiered design grammar that encodes heuristic strategies to aid in the generation of early solution concepts. Specifically, this two-tiered grammar mimics the combination of heuristic-based strategic actions and parametric modifications employed by human designers. Rules in the higher-tier are abstract and potentially applicable to multiple design problems across a number of fields. These abstract rules are translated into a series of lower-tier rule applications in a spatial design grammar, which are inherently domain-specific. This grammar is implemented within the HSAT agent-based algorithm. Agents iteratively select actions from either the higher-tier or lower-tier. This algorithm is applied to the design of wave energy converters, devices which use the motion of ocean waves to generate electrical power. Comparisons are made between designs generated using only lower-tier rules and those generated using only higher-tier rules.
The Significance of Maturation Score of Brain Magnetic Resonance Imaging in Extremely Low Birth Weight Infant (2011)

The aim of this study was to investigate the effect of perinatal risk factors on brain maturation and the relationship of brain maturation and neurodevelopmental outcomes with brain maturation scoring system in brain MRI. Methods: ELBWI infants born at the Seoul National University Children's Hospital from January 2006 to December 2010 were included. A retrospective analysis was performed with their medical record and brain MR images acquired at near full term. We read brain MRI and measured maturity with total maturation score (TMS). TMS is a previously developed anatomic scoring system to assess brain maturity. The total maturation score was used to evaluate the four parameters of maturity: (1) myelination, (2) cortical infolding, (3) involution of glial cell migration bands, and (4) presence of germinal matrix tissue. Results: Images from 124 infants were evaluated. Their mean gestational age at birth was 27.12.1 weeks, and mean birth weight was 781.5143.9 g. The mean TMS was 10.82.0. TMS was significantly related to the postmenstrual age (PMA) of the infant, in creasing with advancing postmenstrual age (P<0.001). TMS showed no significance with neurodevelopmental delay, and with brain injury, respectively. Conclusion: TMS was developed for evaluating brain maturation in conventional brain MRI. The results of this study suggest that TMS was not useful for predicting neurodevelopmental delay, but further studies are needed to make standard score for each PMA and to re-evaluate the relationship between brain maturation and neurodevelopmental delay.
Individual Tree Detection and Classification with UAV-Based Photogrammetric Point Clouds and Hyperspectral Imaging (2017)

Small unmanned aerial vehicle (UAV) based remote sensing is a rapidly evolving technology. Novel sensors and methods are entering the market, offering completely new possibilities to carry out remote sensing tasks. Three-dimensional (3D) hyperspectral remote sensing is a novel and powerful technology that has recently become available to small UAVs. This study investigated the performance of UAV-based photogrammetry and hyperspectral imaging in individual tree detection and tree species classification in boreal forests. Eleven test sites with 4151 reference trees representing various tree species and developmental stages were collected in June 2014 using a UAV remote sensing system equipped with a frame format hyperspectral camera and an RGB camera in highly variable weather conditions. Dense point clouds were measured photogrammetrically by automatic image matching using high resolution RGB images with a 5 cm point interval. Spectral features were obtained from the hyperspectral image blocks, the large radiometric variation of which was compensated for by using a novel approach based on radiometric block adjustment with the support of in-flight irradiance observations. Spectral and 3D point cloud features were used in the classification experiment with various classifiers. The best results were obtained with Random Forest and Multilayer Perceptron (MLP) which both gave 95% overall accuracies and an F-score of 0.93. Accuracy of individual tree identification from the photogrammetric point clouds varied between 40% and 95%, depending on the characteristics of the area. Challenges in reference measurements might also have reduced these numbers. Results were promising, indicating that hyperspectral 3D remote sensing was operational from a UAV platform even in very difficult conditions. These novel methods are expected to provide a powerful tool for automating various environmental close-range remote sensing tasks in the very near future.
Cardiac tamponade mimicking tuberculous pericarditis as the initial presentation of chronic lymphocytic leukemia in a 58-year-old woman: a case report (2010)

Although most malignancies that involve the pericardium clinically manifest elsewhere before presenting with tamponade, this case illustrates the potential for early stage chronic lymphocytic leukemia to present as a large pericardial effusion with tamponade. Moreover, the presentation mimicked tuberculosis. This case also demonstrates that it is possible to treat chronic lymphocytic leukemia-related pericardial tamponade by removal of the fluid without chemotherapy.
Dynamic Decapentaplegic signaling regulates patterning and adhesion in theDrosophilapupal retina (2007)

The correct organization of cells within an epithelium is essential for proper tissue and organ morphogenesis. The role of Decapentaplegic/Bone morphogenetic protein (Dpp/BMP) signaling in cellular morphogenesis during epithelial development is poorly understood. In this paper, we used the developing Drosophila pupal retina--looking specifically at the reorganization of glial-like support cells that lie between the retinal ommatidia--to better understand the role of Dpp signaling during epithelial patterning. Our results indicate that Dpp pathway activity is tightly regulated across time in the pupal retina and that epithelial cells in this tissue require Dpp signaling to achieve their correct shape and position within the ommatidial hexagon. These results point to the Dpp pathway as a third component and functional link between two adhesion systems, Hibris-Roughest and DE-cadherin. A balanced interplay between these three systems is essential for epithelial patterning during morphogenesis of the pupal retina. Importantly, we identify a similar functional connection between Dpp activity and DE-cadherin and Rho1 during cell fate determination in the wing, suggesting a broader link between Dpp function and junctional integrity during epithelial development.
Detection of Circulating Tumor DNA in Human Blood via DNA-Mediated Surface-Enhanced Raman Spectroscopy of Single-Walled Carbon Nanotubes (2016)

The levels of circulating tumor DNA (ctDNA) in the peripheral blood have been associated with tumor burden and malignant progression. However, ultrasensitive detection of ctDNA in blood remains to be explored. Herein, we have developed a new approach, employing DNA-mediated surface-enhanced Raman scattering (SERS) of single-walled carbon nanotubes (SWNTs), that allows ultrasensitive detection of a broad range of ctDNAs in human blood. Combined with the efficient ctDNA recognition capacity of our designed triple-helix molecular switch and RNase HII enzyme-assisted amplification, the T-rich DNA-mediated SERS enhancement of SWNTs could read out a content of KRAS G12DM as low as 0.3 fM, with a detection of 5.0 μL of sample volume, which has potential for point-of-care testing in clinical analysis.
Model-Based VF Technique for Parasitic Reflections Reduction of Frequency-Domain Chipless RFID Systems (2022)

In a frequency-domain chipless RFID system, the backscattered signal from a tag is directly obtained in the frequency domain over limited bandwidth. However, to reduce the parasitic reflections, it is crucial to obtain the backscattered signal in the time domain. This letter proposes a precise quasi-analytic method, known as the model-based vector fitting (VF) technique, to provide the closed-form equation of the backscattered response in the time domain. The proposed method successfully recovers a tag’s identification (ID) among parasitic reflections using a single tag measurement without requiring prior knowledge about the tag.
A robust chaotic communication scheme for a class of dynamical systems (2014)

This paper proposes an observer-based approach for robust chaotic communication with high power plaintext signals. The convergence rate of synchronization can be assigned by appropriately selecting the observer gains. The proposed scheme is carefully designed so that the encrypted signal does not deteriorate the synchronization. The proposed method significantly improves the frequency-domain characteristics of the transmitted secret message. This has the effect of preventing the extraction of the secret message using filtering techniques; hence improved security. Computer simulations show that the synchronization between the transmitter and the receiver is robust for different amplitude values of the information signal even in the presence of external disturbances. The synchronization between the transmitter and the receiver is maintained and the message signal is exactly recovered even for the various types of waveforms (square, trapezoidal, sinusoidal) of plaintext message and while varying the duty cycle and the rising and falling times of the signal.
Mode of inhibitory action of a bacteriocin produced by Streptococcus mutans C3603 (1984)

The basis for the lethal activity of a bacteriocin produced by Streptococcus mutans C3603 (serotype c) was studied. Bacteriocin C3603 was found to adsorb to cells of representative strains of the seven serotypes of S. mutans. S. mutans BHT (serotype b) was used to study the adsorption and the lethal properties of bacteriocin C3603. The adsorption of bacteriocin to cells of S. mutans BHT was inhibited by treatment of cells with protease and beta-glucosidase and by such ligands as poly-L-lysine, poly-L-arginine, L-aspartic acid, L-glutamic acid, glutathione, oxidized glutathione, poly-L-aspartic acid, and poly-L-glutamic acid. The adsorption to cells was also inhibited by oligosaccharides and glucosamine. Mixtures of anionic and cationic amino acids or polyamino acids did not greatly enhance or antagonize the inhibition of adsorption of bacteriocin C3603 to cells. Sodium hydroxide extracts of cell walls and cell wall-membranes contained carbohydrates and proteins; however, only proteins were found to bind to bacteriocin or to a bacteriocin affinity column. The sodium hydroxide extracts contained about 35 protein bands as determined by sodium dodecyl sulfate-polyacrylamide disc gel electrophoresis. Bacteriocin C3603 was found to immediately inhibit the synthesis of proteins, DNA, and RNA of cells and to slowly release DNA from cells of S. mutans BHT.
English verb classes and alternations : a preliminaryinvestigation (1993)

Americanae nace como un proyecto conjunto que surge dentro de la Red Europea de Información y Documentación sobre América Latina (REDIAL), y que ha afrontado la Biblioteca de la Agencia Española de Cooperación Internacional para el Desarrollo (AECID). Esta nueva biblioteca virtual hace más accesibles los libros digitales de tema americanista a los investigadores y usuarios interesados de cualquier parte del mundo.
Janus Molecule I: Dichotomous Effects of COMT in Neuropathic vs Nociceptive Pain Modalities (2012)

The enzyme catechol-O-methyltransferase (COMT) has been shown to play a critical role in pain perception by regulating levels of epinephrine (Epi) and norepinephrine (NE). Although the key contribution of catecholamines to the perception of pain has been recognized for a long time, there is a clear dichotomy of observations. More than a century of research has demonstrated that increasing adrenergic transmission in the spinal cord decreases pain sensitivity in animals. Equally abundant evidence demonstrates the opposite effect of adrenergic signaling in the peripheral nervous system, where adrenergic signaling increases pain sensitivity. Viewing pain processing within spinal and peripheral compartments and determining the directionality of adrenergic signaling helps clarify the seemingly contradictory findings of the pain modulatory properties of adrenergic receptor agonists and antagonists presented in other reviews. Available evidence suggests that adrenergic signaling contributes to pain phenotypes through α(1/2) and β(2/3) receptors. While stimulation of α(2) adrenergic receptors seems to uniformly produce analgesia, stimulation of α(1) or β receptors produces either analgesic or hyperalgesic effects. Establishing the directionality of adrenergic receptor modulation of pain processing, and related COMT activity in different pain models are needed to bring meaning to recent human molecular genetic findings. This will enable the translation of current findings into meaningful clinical applications such as diagnostic markers and novel therapeutic targets for complex human pain conditions.
United States Methods of Evaluating Air Routes in Bilateral Air Agreements (1970)

The theory of air route evaluation is simple. It is to assign a monetary value to each unit of traffic (a passenger or a weight unit of cargo) carried or to be carried between the points constituting the route by the carriers presently or prospectively in operation. The total monetary value is about the same as gross revenues obtained or to be obtained by the carrier or carriers from the implementation of the route rights authorized. The value is related to a period of time, usually a year, which may be a current one or a projection thereof to a future year; in the case of a new route, generally the expected first year of operation.
Evidence of endogenously produced hydrogen sulfide (H2S) and persulfidation in male reproduction (2022)

Persulfidation contributes to a group of redox post-translational modifications (PTMs), which arise exclusively on the sulfhydryl group of cysteine as a result of hydrogen sulfide (H<sub>2</sub>S) action. Redox-active molecules, including H<sub>2</sub>S, contribute to sperm development; therefore, redox PTMs represent an extremely important signalling pathway in sperm life. In this path, persulfidation prevents protein damage caused by irreversible cysteine hyperoxidation and thus maintains this signalling pathway. In our study, we detected both H<sub>2</sub>S and its production by all H<sub>2</sub>S-releasing enzymes (cystathionine γ-lyase (CTH), cystathionine β-synthase (CBS), and 3-mercaptopyruvate sulfurtransferase (MPST)) in male reproduction, including spermatozoa. We provided evidence that sperm H<sub>2</sub>S leads to persulfidation of proteins, such as glyceraldehyde-3-phosphate dehydrogenase, tubulin, and anchor protein A-kinase. Overall, this study suggests that persulfidation, as a part of the redox signalling pathway, is tightly regulated by enzymatic H<sub>2</sub>S production and is required for sperm viability.
Roofing Materials (2000)

Abstract Roofs are a basic element of shelter. As larger and larger roofing structures are desired, building designs become an important element in construction. A modern design normally includes a structure to carry loads, insulation to control heat flow, a barrier to control air and vapor flow, and a roofing element to prevent water penetration. This article discusses all aspects of roofing materials, from manufacturing methods, roofing system performance, specifications and application rates, to economic as well as health, safety, and environmental factors.
[The new tripeptoid neurotensin analog dilept selectively affects dopamine turnover in nucleus accumbens and hypothalamus]. (2006)

The effects of dilept (N-caproyl-L-prolyl-L-tyrosine methyl ester) - a new peptidomimetic of neurotensine - on the level of monoamines and their main metabolites in four functionally important brain structures has been studied upon single and subchronic administration in intact rats and in those pretreated with the NMDA receptor blocker ketamine. Repeated administration of dilept favors the accumulation of DOPAC and accelerates the dopamine (DA) turnover in nucleus accumbens, as manifested by an increase in the DOPAC/DA ratio. The opposite effect (decrease in the DOPAC/DA ratio) was observed in the hypothalamus, where the subchronic treatment with dilept completely inhibited the activating action of ketamine on the DA turnover. The selective influence of dilept on the dopaminergic system activity in nucleus accumbens (but not in striatum), together with the previously obtained behavioral data, suggest that dilept is a new atypical neuroleptic producing no extrapyramidal side effects.
Are We Heading in the Right Direction? (2006)

Editor-in-Chief (Rohrich) Managing Editor, Plastic and Reconstructive Surgery, Dallas, Texas (Sullivan) Correspondence to Mr. Sullivan, Plastic and Reconstructive Surgery, 5323 Harry Hines Boulevard, HX1.636, Dallas, Texas 75390-8820, [email protected]