gebhart/patrepeval huggingface dataset:
Interhemispheric Relations During Bilateral Spike‐and‐Wave Activity (1981)

Temporal relationships between homologous EEG channels of the two hemispheres were studied in patients whose EEGs showed bilateral synchronous spike-and-wave activity. Group A (seven patients) had generalized corticoreticular epilepsy and no sign of a localized predominant epileptogenic area. In group B (12 patients), the bilateral spike-and-wave activity was present in conjunction with a localized area of predominant epileptogenicity demonstrated by EEG, radiological, or clinical examinations. The measurement of small time differences between two homologous channels was performed by transforming the slope of the phase characteristic of the cross-spectrum into time, when the interchannel coherence was sufficiently high. Although measurements were not possible in every case (because of a lack of coherence or nonlinearity of the phase), results clearly indicated that the spike-and-waves in group A did not present significant interhemispheric time differences, whereas those of group B frequently presented a lead time (average 15 msec) from the side with the localized epileptogenic area. The method can be clinically useful to differentiate primary from secondary bilateral synchrony. The concept of secondary bilateral synchrony and the possible pathophysiological mechanisms explaining the time differences are discussed.
Dynamical Effects on the Geometric Phase (2018)

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Scattering properties of polymer gels at the .THETA. temperature (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTScattering properties of polymer gels at the .THETA. temperatureAnne Marie Hecht, Ferenc Horkay, Simon Mallam, and Erik GeisslerCite this: Macromolecules 1992, 25, 25, 6915–6920Publication Date (Print):December 1, 1992Publication History Published online1 May 2002Published inissue 1 December 1992https://pubs.acs.org/doi/10.1021/ma00051a030https://doi.org/10.1021/ma00051a030research-articleACS PublicationsRequest reuse permissionsArticle Views97Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
<title>Mode multiplexing by diffractive optical elements in optical telecommunication</title> (2004)

An increase in the data-carrying abilities of modern communication systems is the most important scientific and technical challenge, requiring further studies of the physical effects involved. The possibility to increase in the data-carrying abilities of optical communication systems by waveguide modes (both <i>longitude</i> and <i>transverse</i>) multiplexing by diffractive optical elements (DOEs) is considered.
A framework for balancing control flow and predication (2002)

Predicated execution is a promising architectural feature for exploiting instruction-level parallelism in the presence of control flow. Compiling for predicated execution involves converting program control flow into conditional, or predicated, instructions. This process is known as if-conversion. In order to effectively apply if-conversion, one must address two major issues: what should be if-converted and when the if-conversion should be applied. A compiler's use of predication as a representation is most effective when large amounts of code are if-converted and if-conversion is performed early in the compilation procedure. On the other hand the final code generated for a processor with predicated execution requires a delicate balance between control flow and predication to achieve efficient execution. The appropriate balance is tightly coupled with scheduling decisions and detailed processor characteristics. This paper presents an effective compilation framework that allows the compiler to maximize the benefits of predication as a compiler representation while delaying the final balancing of control flow and predication to schedule time.
Study of theτ−→3h−2h+ντdecay (2005)

The branching fraction of the ${\ensuremath{\tau}}^{\ensuremath{-}}\ensuremath{\rightarrow}3{h}^{\ensuremath{-}}2{h}^{+}{\ensuremath{\nu}}_{\ensuremath{\tau}}$ decay ($h=\ensuremath{\pi},K$) is measured with the BABAR detector to be $(8.56\ifmmode\pm\else\textpm\fi{}0.05\ifmmode\pm\else\textpm\fi{}0.42)\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}4}$, where the first error is statistical and the second systematic. The observed structure of this decay is significantly different from the phase space prediction, with the $\ensuremath{\rho}$ resonance playing a strong role. The decay ${\ensuremath{\tau}}^{\ensuremath{-}}\ensuremath{\rightarrow}{f}_{1}(1285){\ensuremath{\pi}}^{\ensuremath{-}}{\ensuremath{\nu}}_{\ensuremath{\tau}}$, with the ${f}_{1}(1285)$ meson decaying to four charged pions, is observed and the branching fraction is measured to be $(3.9\ifmmode\pm\else\textpm\fi{}0.7\ifmmode\pm\else\textpm\fi{}0.5)\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}4}$.
The Stress-Sensing TORC2 Complex Activates Yeast AGC-Family Protein Kinase Ypk1 at Multiple Novel Sites (2017)

Yeast (<i>Saccharomyces cerevisiae</i>) target of rapamycin (TOR) complex 2 (TORC2) is a multi-subunit plasma membrane-associated protein kinase and vital growth regulator. Its essential functions are exerted via phosphorylation and stimulation of downstream protein kinase Ypk1 (and its paralog Ypk2). Ypk1 phosphorylates multiple substrates to regulate plasma membrane lipid and protein composition. Ypk1 function requires phosphorylation of Thr504 in its activation loop by eisosome-associated Pkh1 (and its paralog Pkh2). For cell survival under certain stresses, however, Ypk1 activity requires further stimulation by TORC2-mediated phosphorylation at C-terminal sites, dubbed the "turn" (Ser644) and "hydrophobic" (Thr662) motifs. Here we show that four additional C-terminal sites are phosphorylated in a TORC2-dependent manner, collectively defining a minimal consensus. We found that the newly identified sites are as important for Ypk1 activity, stability, and biological function as Ser644 and Thr662. Ala substitutions at the four new sites abrogated the ability of Ypk1 to rescue the phenotypes of Ypk1 deficiency, whereas Glu substitutions had no ill effect. Combining the Ala substitutions with an N-terminal mutation (D242A), which has been demonstrated to bypass the need for TORC2-mediated phosphorylation, restored the ability to complement a Ypk1-deficient cell. These findings provide new insights about the molecular basis for TORC2-dependent activation of Ypk1.
Analyses of vitamin B6 in extractives of food materials by high-performance liquid chromatography (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAnalyses of vitamin B6 in extractives of food materials by high-performance liquid chromatographyFrancis F. WongCite this: J. Agric. Food Chem. 1978, 26, 6, 1444–1446Publication Date (Print):November 1, 1978Publication History Published online1 May 2002Published inissue 1 November 1978https://pubs.acs.org/doi/10.1021/jf60220a044https://doi.org/10.1021/jf60220a044research-articleACS PublicationsRequest reuse permissionsArticle Views78Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Ten rules of hard bargaining (2000)

Extract:Most negotiations conclude with a period of hard bargaining â adversarial negotiation in which one dollar more for me is one less for you â and many commence with it. There are in our culture at least 10 generally applicable rules for hard bargaining. There are surely more; however, the 10 rules I have identified follow.
? (1995)

We performed this study to assess the feasibility and effectiveness of ultrasound-guided drainage and ethanol instillation for the treatment of pelvic peritoneal cysts. Six women had pelvic peritoneal cysts after previous pelvic surgery; when the cysts recurred after simple drainage, the patients underwent transvaginal ultrasound-guided drainage and instillation of 20-30 mL of ethanol into the cyst cavity. All patients except one presented with abdominal pain. All cysts had clinical and ultrasonic benign characteristics. Drainage and ethanol instillation were performed successfully in all patients without severe side effects or complications. After a mean follow-up time of 13.6 months, a recurrence was found in only one patient, who was successfully retreated. These preliminary results indicate that transvaginal ultrasound-guided fluid drainage and ethanol instillation is an effective treatment for pelvic peritoneal cysts.
Isolation and Identification of a New Pregnene Glycoside from the Gorgonian Pseudoplexaura wagenaari (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIsolation and Identification of a New Pregnene Glycoside from the Gorgonian Pseudoplexaura wagenaariJohn M. Wasylyk, Gary E. Martin, Alfred J. Weinheimer, and Maktoob AlamCite this: J. Nat. Prod. 1989, 52, 2, 391–394Publication Date (Print):March 1, 1989Publication History Published online1 July 2004Published inissue 1 March 1989https://pubs.acs.org/doi/10.1021/np50062a031https://doi.org/10.1021/np50062a031research-articleACS PublicationsRequest reuse permissionsArticle Views101Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Pb1-xSnxTe/PbTe1-ySeylattice-matched buried heterostructure lasers with CW Single mode output (1980)

The first successful realization of buried heterostructure diode lasers in the PbSnTe/PbTeSe system is reported. This has resulted in routine cw operation above 80 K with threshold currents as low as 60 mA in 5 µm wide stripe lasers. CW operation has been achieved to 120K. In addition, these lasers operate in the fundamental transverse mode up to as much as four times threshold.
Chemistry of Carbon Nanotubes (2006)

ADVERTISEMENT RETURN TO ISSUEPREVArticleChemistry of Carbon NanotubesDimitrios Tasis, Nikos Tagmatarchis, Alberto Bianco, and Maurizio PratoView Author Information Department of Materials Science, University of Patras, 26504 Rio Patras, Greece, Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation, 48 Vass. Constantinou Avenue, 116 35 Athens, Greece, Institut de Biologie Moléculaire et Cellulaire, UPR9021 CNRS, Immunologie et Chimie Thérapeutiques, 67084 Strasbourg, France, and Dipartimento di Scienze Farmaceutiche, Università di Trieste, Piazzale Europa 1, 34127 Trieste, Italy Cite this: Chem. Rev. 2006, 106, 3, 1105–1136Publication Date (Web):February 23, 2006Publication History Received12 July 2005Published online23 February 2006Published inissue 1 March 2006https://pubs.acs.org/doi/10.1021/cr050569ohttps://doi.org/10.1021/cr050569oresearch-articleACS PublicationsCopyright © 2006 American Chemical SocietyRequest reuse permissionsArticle Views42370Altmetric-Citations3637LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Carbon nanotubes,Composites,Functionalization,Materials,Polymers Get e-Alerts
An in-depth multicentered population-based analysis of outcomes of patients with metastatic renal cell carcinoma (mRCC) that do not meet eligibility criteria for clinical trials. (2012)

4536 Background: Clinical trials have strict eligibility criteria that exclude many patients to whom the trial results are later extrapolated to in clinical practice. Methods: mRCC patients treated with VEGF targeted therapy were retrospectively deemed ineligible for clinical trials (according to commonly used inclusion/exclusion criteria) if they had a Karnofsky Performance Status (KPS) &lt;70%, brain metastases, non-clear cell histology, hemoglobin&lt;=9 g/dL, creatinine &gt;2x the upper limit of normal, platelet count of &lt;100x10 3 /uL, neutrophil count &lt;1500/mm 3 or corrected calcium&gt;=12 mg/dL. Results: 894/2076 (43%) patients were deemed ineligible for clinical trials by the above criteria. Between ineligible versus eligible patients, the response rate, median progression free survival (PFS) and median overall survival of first-line targeted therapy were 21% vs 29%, 5.2 vs 8.8 months and 14.5 vs 28.8 months (all p&lt;0.0001), respectively. Second-line PFS (if applicable) was 3.2 months in the trial ineligible vs 4.4 months in the trial eligible patients (p=0.0074). Patients who were excluded due to KPS&lt;70, hemoglobin&lt;=9 g/dL, calcium &gt;=12, brain metastases, and non-clear cell histology, had a hazard ratio (HR) for death of 2.8 (95%CI 2.4-3.4), 1.8 (95%CI 1.4-2.2), 1.8 (95%CI 1.2-2.7), 1.4 (95%CI 1.1-1.8), and 1.4 (95%CI 1.1-1.7), respectively (all p&lt;0.01). When adjusted by the Heng et al prognostic categories, the HR for death between trial ineligible vs trial eligible patients was 1.511 (95%CI=1.335-1.710, p&lt;0.0001). Conclusions: The number of patients that are ineligible for clinical trials is high and their outcomes are inferior. Specific trials addressing the needs of protocol ineligible patients and assessing OS are required. [Table: see text]
Slow light in various media: a tutorial (2010)

I consider the physical basics of slow light propagation in atomic media, photonic
structures, and optical fibers. I show similarities and differences between all of
the above media and develop set of criteria that are then used to compare different
media. Special attention is given to dispersion of group velocity and loss, which are
shown to limit the bandwidth and delay capacity of all the slow light schemes.
Advanced Well Completion Designs to Meet Unique Reservoir and Production Requirements (2014)

Abstract Well Completions design is continuously evolving to meet increasing requirements of down hole monitoring and control. The design of well completion has become more sophisticated as these requirements increase. Nowadays in the industry, it is rare to find a well completion that does not have some type of down hole sensor or inflow control. This paper presents overview of six different well completions designed to meet different reservoir and production requirements. Each of these design are integrations of existing and new technologies. The technologies presented in the paper range from inflow control devices and open hole packers placed in the reservoir section, multilateral junction systems, through permanent down hole sensors, surface controlled down hole valves and electric submersible pumps in the production tubing. The paper also discusses briefly the integration of the down hole equipment with surface control panels and SCADA communication systems. Different well types like oil producers, water injectors and artificial lift wells are discussed.
Noggin Is a Negative Regulator of Neuronal Differentiation in Developing Neocortex (2000)

Bone morphogenetic proteins (BMPs) trigger neuronal differentiation of neocortical precursors within the ventricular zone (VZ) [Li et al. (1998): J Neurosci 18:8853-8862]. BMP-2/4 protein is concentrated at the VZ surface and BMPs rapidly promote the differentiation of neocortical precursors in both dissociated cell and explant cultures. Noggin binds to BMP-2/4 with high affinity, and prevents binding to cell surface receptors. In the present study, we used human recombinant noggin protein to determine whether endogenous BMP-2/4 triggers neuronal differentiation in dissociated cell culture. We find that noggin inhibits the differentiation of neocortical neurons: noggin decreases the number of MAP-2- and TUJ1-positive cells after 24 h of treatment, yet has no effect on either proliferation or cell survival. Noggin also significantly decreases neurite growth of MAP-2-positive cells. In addition, using Western blot analysis we show that noggin protein is present in developing cortex at E15. These results are consistent with previous results showing that endogenous BMPs trigger neuronal differentiation in the neocortical VZ and also indicate that a balance of noggin and BMP may regulate the differentiation of neocortical neurons in vivo.
Specific inhibition of transforming growth factor‐β2 expression in human osteoblast cells by antisense phosphorothioate oligonucleotides (2001)

To elucidate the role of endogenous transforming growth factor (TGF)‐β2 on human osteoblast cell, antisense phosphorothioate oligonucleotides (S‐ODNs) complementary to regions in mRNA of TGF‐β2 were synthesized and examined their effects on TGF‐β2 production and cell proliferation in a human osteoblast cell line ROS 17/2. Antisense S‐ODNs were designated for three different target regions in the mRNA of TGF‐β2. Among several antisense S‐ODN analyzed, an oligonucleotide (AS‐11) complementary to the translation initiation site of mRNA of TGF‐β2 demonstrated a selective and strong inhibitory effect on TGF‐β2 production in osteoblast cells. Other antisense S‐ODNs which were designated for other regions in mRNA of TGF‐β2 and one‐ or three‐base mismatched analogs of AS‐11 showed little or much less antisense activities than AS‐11. Therefore, the most effective target site in mRNA of TGF‐β2 is at the initiation codon region. The antisense effects of AS‐11 were observed without reduction of levels of mRNA of TGF‐β2. Furthermore, the inhibition of TGF‐β2 expression by antisense S‐ODN appeared to enhance cell proliferation, demonstrating the growth inhibitory effect of autocrine TGF‐β2 in osteoblast cells.
Design, Synthesis and Structure—Activity Relationship of Novel RXR‐Selective Modulators. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
The Effect of 6-Thioguanine on Alternative Splicing and Antisense-Mediated Exon Skipping Treatment for Duchenne Muscular Dystrophy (2012)

The severe muscle wasting disorder Duchenne muscular dystrophy (DMD) is caused by genetic defects in the DMD gene, leading to a complete absence of dystrophin protein. Of the therapeutic approaches addressing the underlying genetic defect, exon skipping through antisense oligonucleotides (AONs) is the closest to clinical application. Several strategies to improve the efficiency of this approach are currently being investigated, such as the use of small chemical compounds that improve AONmediated exon skipping levels. Recently, enhanced exon skipping in combination with a guanine analogue, 6-thioguanine (6TG) was reported for phosphorodiamidate morpholino oligomers (PMO). Here the effect of 6TG on the exon skipping efficacy of 2'-O-methyl phosphorothioate RNA (2OMePS) and PMO AONs in vitro and in vivo was further evaluated, as well as the effect of 6TG by itself. Results confirm an increase of exon skipping levels in vitro, however, in contrast to the previous report, no effect was observed in vivo. Importantly, 6TG treatment in vitro resulted in numerous additional DMD exon skipping events. This, in combination with the known cytotoxic effects of 6TG after incorporation in DNA, warrants reconsidering of the use of 6TG as enhancer of AON efficiency in DMD, were chronic treatment will be required.