gebhart/patrepeval huggingface dataset:
Fold-Related Fracture Distribution in Neogene, Triassic, and Jurassic Sandstone Outcrops, Northern Margin of the Tarim Basin, China: Guides to Deformation in Ultradeep Tight Sandstone Reservoirs (2021)

Abstract Ultradeep (6-8 km depth) low-porosity sandstone oil and gas reservoirs, in the Kuqa thrust belt of Tarim Basin, are an important natural gas supply source of China. Both opening and shear-mode fractures are extremely necessary reservoir elements for gas production in these rocks but are challenging to characterize with sparse core and well log observations. Here, we use outcrops of some of the same units from four exposed folds to describe fracture types and patterns. These four folds have a range of shapes that are representative of folds at depth. At the Dongq, Kuqa, Misib, and Tuger anticlines, we analyzed fracture type, cross-cutting and abutting relations, density, spatial arrangement, kinematic aperture, orientation, and mineral fill. One-dimensional inventories, field sketches, photographs, and LiDAR imagery documented fracture patterns. Most dips of all fractures shown everywhere on the fold are greater than 60 degrees (over 50%). Fracture kinematic apertures are 3 mm to ~6 mm, and fracture density is 0.5 traces/m to ~1.5 traces/m. All fractures are divided into shear mode (or small faults) and opening mode. Shear-mode fractures, with high dips that strike N-S, mutually crosswise arranged with intersection angles of 30-60 degrees, are found extensively on the flanks of these folds. In contrast, most opening-mode fractures strike E-W, are arranged parallel to each other, and are localized in fold hinges. Besides, exposed folds (reservoir analogues, figure 1) in a proximal (hinterland, Tuger and Misib) position have fracture abundance distributions and aperture size patterns compatible with fold-related fracture development whereas distal (basinward, Kuqa and Dongq) folds lack this correlation, but patterns in distal folds might be explained by overprinted effects of lithological heterogeneity on fracture abundance or the effects of nearby faults. The positive correlation between fold-related strain and fracture spatial distribution in the northern (proximal) folds permitted inference of fracture patterns in deep wells.
Effects of war and organized violence on children: A study of Bosnian refugees in Sweden. (2001)

Data from 99 school-aged Bosnian refugee children living in Sweden were analyzed to reveal the patterns of war stress experienced and the relation between these stressors and current psychological problems. A significant pattern of associations emerged. When children had experienced much stress, talking about their experiences seemed to exacerbate their negative effects.
Statistics of low-frequency multipath fluctuations in the ocean (1978)

Statistics of fluctuations of low-frequency sound in the ocean are analyzed for an arbitrary number of paths. Covariances are derived for the intensity, phase rate (time derivative of the phase), and related parameters. Power spectra are derived from the covariances. The multipath results are based on weakly fluctuating single paths whose phase is perturbed by the internal-wave field. The theory is illustrated by deriving some results for a single internal wave. We specialize to a large number of equal energy paths by appealing to the central-limit theorem which states that the Cartesian components for the multipath field are Gaussian distributed. Some results available in the literature are shown to be valid for the special case of a large number of paths. Power spectra for data obtained in a recent experiment are shown to follow the predictions of this analysis.
Cardiac myoglobin in myoglobinuria. (1966)

Studies were undertaken to determine whether significant abnormalities were present in cardiac myoglobin in a case of primary paroxysmal myoglobinuria.No qualitative abnormality was found in cardiac myoglobin from a patient with myoglobinuria, compared to normal controls, using urea starch gel electrophoresis. Quantitative analysis, however, revealed depletion of cardiac myoglobin in the patient with myoglobinuria.It is considered that the basic defect in primary paroxysmal myoglobinuria is not related to myoglobin per se, and although evidence is lacking, an autoimmune process, as encountered in some of the hemolytic anemias, may be involved in this condition.
Ligand Binding to Truncated Hemoglobin N from Mycobacterium tuberculosis Is Strongly Modulated by the Interplay between the Distal Heme Pocket Residues and Internal Water (2008)

The survival of Mycobacterium tuberculosis requires detoxification of host *NO. Oxygenated Mycobacterium tuberculosis truncated hemoglobin N catalyzes the rapid oxidation of nitric oxide to innocuous nitrate with a second-order rate constant (k'(NOD) approximately 745 x 10(6) m(-1) x s(-1)), which is approximately 15-fold faster than the reaction of horse heart myoglobin. We ask what aspects of structure and/or dynamics give rise to this enhanced reactivity. A first step is to expose what controls ligand/substrate binding to the heme. We present evidence that the main barrier to ligand binding to deoxy-truncated hemoglobin N (deoxy-trHbN) is the displacement of a distal cavity water molecule, which is mainly stabilized by residue Tyr(B10) but not coordinated to the heme iron. As observed in the Tyr(B10)/Gln(E11) apolar mutants, once this kinetic barrier is lowered, CO and O(2) binding is very rapid with rates approaching 1-2 x 10(9) m(-1) x s(-1). These large values almost certainly represent the upper limit for ligand binding to a heme protein and also indicate that the iron atom in trHbN is highly reactive. Kinetic measurements on the photoproduct of the *NO derivative of met-trHbN, where both the *NO and water can be directly followed, revealed that water rebinding is quite fast (approximately 1.49 x 10(8) s(-1)) and is responsible for the low geminate yield in trHbN. Molecular dynamics simulations, performed with trHbN and its distal mutants, indicated that in the absence of a distal water molecule, ligand access to the heme iron is not hindered. They also showed that a water molecule is stabilized next to the heme iron through hydrogen-bonding with Tyr(B10) and Gln(E11).
Structural Similarity based image quality map for face recognition across plastic surgery (2013)

Variations in the face appearance caused by plastic surgery on skin texture and geometric structure, can impair the performance of most current face recognition systems. In this work, we proposed to use the Structural Similarity (SSIM) quality map to detect and model variations due to plastic surgeries. In the proposed framework, a S-SIM index weighted multi-patch fusion scheme is developed, where different weights are provided to different patches in accordance with the degree to which each patch may be altered by surgeries. An important feature of the proposed approach, also achieving performance comparable with the current state-of-the-art, is that neither training process is needed nor any background information from other datasets is required. Extensive experiments conducted on a plastic surgery face database demonstrate the potential of SSIM map for matching face images after surgeries.
Seismic processing and interpretation in colour (2013)

Andreas Laake and Joseph Carl Fiduk present a method of structurally sharpened visualization of seismic data which provides an environment and workflows that allow users to better interrogate 3D seismic data and isolate the important geologic details, with examples of its application in a challenging deepwater area of the Gulf of Mexico.
3‐D interpretation using interactive graphics (1983)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 19833‐D interpretation using interactive graphicsAuthors: A. AlamM. FrancisA. ArdaliM. MartinA. AlamWestern Geophysical, England, M. FrancisWestern Geophysical, England, A. ArdaliWestern Geophysical, England, and M. MartinWestern Geophysical, Englandhttps://doi.org/10.1190/1.1893735 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1893735FiguresReferencesRelatedDetails SEG Technical Program Expanded Abstracts 1983ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1983 Pages: 646 publication data© 1983 Copyright © 1983 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished: 24 Mar 2005 CITATION INFORMATION A. Alam, M. Francis, A. Ardali, and M. Martin, (1983), "3‐D interpretation using interactive graphics," SEG Technical Program Expanded Abstracts : 544-546. https://doi.org/10.1190/1.1893735 Plain-Language Summary PDF DownloadLoading ...
Complete Primary Structure of the Human Estrogen-Responsive Gene (pS2) Product. (1991)

pS2 is a human gene whose transcription is directly triggered by estrogen in human breast cancer cells (MCF-7). We described here the complete primary structure of the pS2 gene product. The pS2 protein purified from conditioned medium of MCF-7 cells was S-pyridylethylated and digested with TPCK-trypsin. Five major fragments were obtained by reverse-phase HPLC. Amino acid sequence analysis of these tryptic peptides established that the pS2 protein comprises a 60-amino acid polypeptide. The sequence of the pS2 protein was completely identical to that deduced from the nucleotide sequence of the pS2 gene, if the signal polypeptide is excluded. Furthermore, two cDNA clones encoding an 84-amino acid precursor pS2 protein were isolated from a cDNA library which was constructed with RNA from MCF-7 cells cultured in the presence of estrogen. The nucleotide sequence of one clone (pS2B1) was identical to that of pS2 cDNA previously reported except for one nucleotide in the 3' untranslated region. The other clone (pS2B2) was longer by 73 nucleotides, at the 5' end, than pS2B1. The additional 73 nucleotides are located just upstream of the sequence of pS2B1 in the structure of the pS2 gene, indicating that the pS2 gene has two start sites for transcription. However, a mRNA molecule corresponding to pS2B1 but not to pS2B2 was detected in the cells on RNA blot hybridization analysis, indicating that one transcriptional start site is mainly used.
Preparation and Evaluation of a Novel Hypoxic Imaging Agent ~(99)Tc~m(CO)_3-MNLS (2011)

The labeling method for 99Tcm(CO)3-MNLS was established,and the biodistribution of 99Tcm(CO)3-MNLS in EMT-6 tumor-bearing mice was carried out as well.The optimal labeling condition was found as follows: MNLS 10 mg,pH=4.0-8.0 at 80 ℃ for 15 min;and the radiochemical purity was more than 99% proved by HPLC.The new radiolabeled compound's stability was good in vitro,and it was electrically neutral and water-soluble.The biodistribution in EMT-6 tumor-bearing mice show that: 99Tcm(CO)3-MNLS has a considerable uptake and eligible retention time in tumor,and the bone uptake of 99Tcm(CO)3-MNLS is much lower than 99Tcm-MNLS.
Human Langerhans cells selectively activated via Toll-like receptor 2 agonists acquire migratory and CD4+T cell stimulatory capacity (2008)

In epidermal Langerhans cells (LCs), the expression pattern and the functions of TLRs have been poorly characterized. By using mAb, we show that LCs from human skin express TLR1, -2, -5, -6, and -9, the cognate receptors for detection of specific bacteria-derived molecules. As compared with other TLR agonists, LCs acquired a more matured phenotype when activated by specific bacterial or synthetic TLR2 agonists. In addition, monocyte-derived Langerin(+)/CD1c(+)LCs (CD1c(+)MoLCs) secreted higher amounts of IL-6 and TNF-alpha by stimulation via TLR2 than by stimulation via TLR3, -4, -5, -8, and -9. In contrast to MoLCs, dendritic cells, generated from the same donor monocytes, were activated by agonists of TLRs other than TLR2 as well. Lipopeptides triggering TLR2 induced IL-1R-associated kinase-1 phosphorylation and migration toward the chemokines CCL19 and CCL21 in epidermal LCs and CD1c(+)MoLCs. Up-regulation of CD86, CD83, and CCR7, TNF-alpha and IL-6, and NF-kappaB activation and proliferation of CD4(+)T cells could be inhibited TLR2-specific blockage using antibodies prior to TLR2 activation. Application of anti-TLR1, anti-TLR6, and anti-TLR2 indicated an exclusive role of TLR2 in IL-6 induction in human LCs. Collectively, our results show that TLR2 expressed by LCs mediates inflammatory responses to lipopeptides, which implicates a central role in sensing pathogens in human skin.
New kid on the block: ONC201 in NHL (2015)

Treatment of relapsed aggressive non-Hodgkin lymphoma (NHL), including diffuse large B-cell lymphoma, Burkitt's lymphoma and mantle cell lymphoma, is challenging. The treatment options for these lymphomas include a combination of stem cell transplantation, radiation, targeted therapies, and intensive chemotherapy regimens. However, many patients relapse due to the development of resistance, and relapsed aggressive NHL remains incurable. Furthermore, resistance increases over multiple treatment courses with various therapies; therefore, there is a clear unmet need for safe and effective agents that overcome resistance by targeting novel pathways.

ONC201 is an orally active novel small molecule anti-cancer agent with an encouraging preclinical safety and efficacy profile that recently entered clinical trials in advanced cancers. In this issue, Talekar et al reports on the therapeutic potential of ONC201 in refractory NHL.1 The authors expand on a prior report of in vivo efficacy in murine lymphoma2 to focus on MCL and Burkitt's lymphoma. The preclinical studies demonstrate that single agent ONC201 induces apoptosis and activates the TRAIL pathway in NHL cells. Further preclinical studies are examining the mechanism of action of ONC201 upstream of TRAIL, which involves a unique activation of a maladaptive ER stress response.3 The study also identifies in vitro synergy with cytarabine in NHL, which adds to the potential for combination therapies that could be deployed in clinical trials.4

A first-in-man clinical trial is ongoing in solid tumors (NCT02250781) and additional clinical trials are being initiated in select advanced cancers, including a monoagent phase I/II clinical trial in relapsed/refractory aggressive NHL (NCT02420795). While no pediatric clinical studies have been initiated for ONC201, its lack of genotoxicity5 and the preclinical efficacy reported by Talekar et al suggest that Burkitt's lymphoma may warrant clinical investigation following confirmation of its safety profile in adult phase I trials.
Bioprospecting for Bioactive Peptide Production by Lactic Acid Bacteria Isolated from Fermented Dairy Food (2019)

With rapidly ageing populations, the world is experiencing unsustainable healthcare from chronic diseases such as metabolic, cardiovascular, neurodegenerative, and cancer disorders. Healthy diet and lifestyle might contribute to prevent these diseases and potentially enhance health outcomes in patients during and after therapy. Fermented dairy foods (FDFs) found their origin concurrently with human civilization for increasing milk shelf-life and enhancing sensorial attributes. Although the probiotic concept has been developed more recently, FDFs, such as milks and yoghurt, have been unconsciously associated with health-promoting effects since ancient times. These health benefits rely not only on the occurrence of fermentation-associated live microbes (mainly lactic acid bacteria; LAB), but also on the pro-health molecules (PHMs) mostly derived from microbial conversion of food compounds. Therefore, there is a renaissance of interest toward traditional fermented food as a reservoir of novel microbes producing PHMs, and “hyperfoods” can be tailored to deliver these healthy molecules to humans. In FDFs, the main PHMs are bioactive peptides (BPs) released from milk proteins by microbial proteolysis. BPs display a pattern of biofunctions such as anti-hypertensive, antioxidant, immuno-modulatory, and anti-microbial activities. Here, we summarized the BPs most frequently encountered in dairy food and their biological activities; we reviewed the main studies exploring the potential of dairy microbiota to release BPs; and delineated the main effectors of the proteolytic LAB systems responsible for BPs release.
Investigation on the Electrical Properties of CdO/ZnO thin films using THz Spectroscopy (2019)

In this work, we study the electrical properties of transparent conducting oxides using physical and optical techniques. The objective is to characterize the conductivity of a series of cadmium oxide zinc-oxide thin films with varying cadmium concentrations using three methods. The Hall Effect estimates carrier concentration, sheet conductivity, and carrier mobility. Optical methods, such as FTIR spectroscopy, can provide estimates of the plasma frequency, which describes a metal’s transition from being transparent to opaque to light. THz spectroscopy extracts the complex conductivity of materials in the far infrared spectrum and provides insights on the optical transport properties of conductors. Our findings show that DC/AC measurements of the conductivity of Cd/ZnO thin films exhibit frequency independent conductivity, indicating that the films are homogeneous Drude metals.
A Color Segmentation And Classification Scheme For Facial Image And Video Retrieval (1998)

Publication in the conference proceedings of EUSIPCO, Rhodes, Greece, 1998
What makes things cool? (2011)

research-article Share on What makes things cool?: intentional design for innovation Author: Karen Holtzblatt InContext InContextView Profile Authors Info & Claims InteractionsVolume 18Issue 6November + December 2011 pp 40–47https://doi.org/10.1145/2029976.2029988Online:01 November 2011Publication History 16citation3,312DownloadsMetricsTotal Citations16Total Downloads3,312Last 12 Months338Last 6 weeks39 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Platelet Function in the Newborn (1998)

Whole blood flow cytometry, an important new method for the assessment of platelet function, is particularly advantageous for neonatal studies because only minuscule volumes (approximately 2 microL) of blood are required. By this method, we have demonstrated that neonatal platelets are less reactive than adult platelets to physiological agonists in whole blood, as determined by the activation-induced increase in the platelet surface expression of P-selectin and the glycoprotein (GP) IIb-IIIa complex and by the activation-induced decrease in the platelet surface expression of the GPIb-IX complex. Our data suggest that the mechanism of neonatal platelet hyporeactivity is, at least in part, a relative defect in a common signal transduction pathway. We have further demonstrated that the platelets of very low birth weight (VLBW) preterm neonates are maximally hyporeactive on days 3 to 4 of life but return to almost the adult range by days 10 to 14. Given that intraventricular hemorrhage (IVH) is also maximal on days 3 to 4, these defects may contribute to the propensity of VLBW preterm neonates to IVH.
Investigation of Glycosyl Nitrates as Building Blocks for Chemical Glycosylation (2018)

Glycosyl nitrates are important synthetic intermediates in the synthesis of 2-amino sugars, 1,2-orthoesters or, more recently, 2-OH glucose. However, glycosyl nitrates have never been glycosidated. Presented herein is our first attempt to use glycosyl nitrates as glycosyl donors for <i>O</i>-glycosylation. Lanthanide triflates showed good affinity to activate the nitrate leaving group.
A Chalcogenide Glass Electrode Sensitive to Cupric Ions (1974)

Electrodes formed from the chalcogenide glass, , are selective to cupric copper in concentrated solutions of chloride, bromide, nitrate, and acetate over the concentration range of 10−1 to at least 10−6M copper. Nernstian slopes of approximately 30 mV/decade concentration changes were observed in nitrate and acetate solutions; slopes of 50 mV/decade were observed in 1M chloride and bromide electrolytes. A slope of 40 mV/decade was observed in 0.1M chloride solution. The active phase in the electrode material appears to be "sinnerite" ; data on the sensing mechanism are presented.
Committee on Natural Toxins and Food Allergens: Phycotoxins (2001)

Peer reviewed: Yes
TNF-α elicits phenotypic and functional alterations of vascular smooth muscle cells by miR-155-5p–dependent down-regulation of cGMP-dependent kinase 1 (2018)

cGMP-dependent protein kinase 1 (PKG1) plays an important role in nitric oxide (NO)/cGMP-mediated maintenance of vascular smooth muscle cell (VSMC) phenotype and vasorelaxation. Inflammatory cytokines, including tumor necrosis factor-α (TNFα), have long been understood to mediate several inflammatory vascular diseases. However, the underlying mechanism of TNFα-dependent inflammatory vascular disease is unclear. Here, we found that TNFα treatment decreased PKG1 expression in cultured VSMCs, which correlated with NF-κB-dependent biogenesis of miR-155-5p that targeted the 3'-UTR of PKG1 mRNA. TNFα induced VSMC phenotypic switching from a contractile to a synthetic state through the down-regulation of VSMC marker genes, suppression of actin polymerization, alteration of cell morphology, and elevation of cell proliferation and migration. All of these events were blocked by treatment with an inhibitor of miR-155-5p or PKG1, whereas transfection with miR-155-5p mimic or PKG1 siRNA promoted phenotypic modulation, similar to the response to TNFα. In addition, TNFα-induced miR-155-5p inhibited the vasorelaxant response of de-endothelialized mouse aortic vessels to 8-Br-cGMP by suppressing phosphorylation of myosin phosphatase and myosin light chain, both of which are downstream signal modulators of PKG1. Moreover, TNFα-induced VSMC phenotypic alteration and vasodilatory dysfunction were blocked by NF-κB inhibition. These results suggest that TNFα impairs NO/cGMP-mediated maintenance of the VSMC contractile phenotype and vascular relaxation by down-regulating PKG1 through NF-κB-dependent biogenesis of miR-155-5p. Thus, the NF-κB/miR-155-5p/PKG1 axis may be crucial in the pathogenesis of inflammatory vascular diseases, such as atherosclerotic intimal hyperplasia and preeclamptic hypertension.