gebhart/patrepeval huggingface dataset:
Hyperthermia in Human Ischemic and Hemorrhagic Stroke: Similar Outcome, Different Mechanisms (2013)

Hyperthermia is a predictor of poor outcome in ischemic (IS) and intracerebral hemorrhagic (ICH) stroke. Our aim was to study the plausible mechanisms involved in the poor outcome associated to hyperthermia in stroke. We conducted a casecontrol study including patients with IS (n = 100) and ICH (n = 100) within the first 12 hours from symptom onset. Specifically, IS and ICH patients were consecutively included into 2 subgroups, according to the highest body temperature within the first 24 hours: Tmax ,37.5uC and Tmax $37.5uC, up to reach 50 patients per subgroup of temperature for both IS and ICH patients. Body temperature was determined at admission and every 4 hours during the first 48 hours. Main outcome variable was poor functional outcome (modified Rankin scale score .2) at 3 months. Serum levels of glutamate and active MMP-9 were measured at admission. Our results showed that Tmax $37.5uC within the first 24 hours was independently associated with poor outcome in both IS (OR, 12.43; 95% CI, 3.73-41.48; p,0.0001) and ICH (OR, 4.29; 95% CI,; p = 0.015) after adjusting for variables with a proven biological relevance for outcome. However, when molecular markers levels were included in the logistic regression model, we observed that glutamate (OR, 1.01; 95% CI, 1.00-1.02; p = 0.001) and infarct volume (OR, 1.06; 95% CI, 1.01-1.10; p = 0.015) were the only variables independently associated to poor outcome in IS, and active MMP-9 (OR, 1.04; 95% CI, 1.00-1.08; p = 0.002) and National Institute of Health Stroke Scale (NIHSS) at admission (OR, 1.29; 95% CI, 1.13-1.49; p,0.0001) in ICH. In conclusion, these results suggest that although the outcome associated to hyperthermia is similar in human IS and ICH, the underlying mechanisms may be different.
Antimicrobial susceptibilities of Campylobacter strains isolated from food animals in Belgium (2001)

Campylobacter spp. are a frequent cause of diarrhoea in man, originating mostly from poultry. It has been suggested that the veterinary use of antibiotics is largely responsible for resistance in human isolates, particularly to quinolones. During a 6 month period from June to December 1998, 677 Campylobacter isolates were obtained from healthy poultry and pigs. Samples were taken at Belgian slaughterhouses. Species identification was performed by biochemical tests, multiplex PCR and SDS-PAGE of whole-cell proteins. The in vitro susceptibility to six antimicrobial drugs was determined by the agar dilution method. Campylobacter jejuni was found more often in poultry than Campylobacter coli (79% C. jejuni versus 21% C. coli). In pigs the situation was reversed (6 versus 94%). Erythromycin resistance was significantly higher (P < 0.05) in C. coli, particularly in C. coli isolated from pigs (67.2%). Alarmingly high rates of resistance to ciprofloxacin were also noted, particularly for C. coli from broilers (62.1%). The latter indicates that resistance of Campylobacter in humans could derive from animals.
The eye and visual optical instruments (1998)

There is a wide variety of optical instruments where the human eye forms an integral part of the overall system. This book provides a detailed description of the visual ergonomics of such instruments. The book begins with a section on image formation and basic optical components. The various optical instruments that can be adequately described using geometrical optics are then discussed, followed by a section on diffraction and interference, and the instruments based on these effects. There are separate sections devoted to ophthalmic instruments and aberration theory, with a final section covering visual ergonomics in depth. Containing many problems and solutions, this book will be of great use to undergraduate and graduate students of optometry, optical design, optical engineering, and visual science, and to professionals working in these and related fields.
Supplementary Methods, Tables 1 - 3, Figure Legend from HOXB7 Promotes Malignant Progression by Activating the TGFβ Signaling Pathway (2023)

&lt;p&gt;Table S1. The clinicopathological characteristics of clinical samples. Table S2. Primer sequences used in the cloning and quantitative PCR analysis. Table S3. Primer sequences used for the CHIP assay.&lt;/p&gt;
Cortical Brain Stimulation with Endovascular Electrodes (2018)

Electrical stimulation of neural tissue and recording of neural activity are the bases of emerging prostheses and treatments for spinal cord injury, stroke, sensory deficits, and drug-resistant neurological disorders. Safety and efficacy are key aspects for the clinical acceptance of therapeutic neural stimulators. The cortical vasculature has been shown to be a safe site for implantation of electrodes for chronically recording neural activity, requiring no craniotomy to access high-bandwidth, intracranial EEG. This work presents the first characterization of endovascular cortical stimulation measured using cortical subdural surface recordings. Visual stimulation was used to verify electrode viability and cortical activation was compared with electrically evoked activity. Due to direct activation of the neural tissue, the latency of responses to electrical stimulation was shorter than for that of visual stimulation. We also found that the center of neural activation was different for visual and electrical stimulation indicating an ability of the stentrode to provide localized activation of neural tissue.
Surprise Search (2016)

Grounded in the divergent search paradigm and inspired by the principle of surprise for unconventional discovery in computational creativity, this paper introduces surprise search as a new method of evolutionary divergent search. Surprise search is tested in two robot navigation tasks and compared against objective-based evolutionary search and novelty search. The key findings of this paper reveal that surprise search is advantageous compared to the other two search processes. It outperforms objective search and it is as efficient as novelty search in both tasks examined. Most importantly, surprise search is, on average, faster and more robust in solving the navigation problem compared to objective and novelty search. Our analysis reveals that surprise search explores the behavioral space more extensively and yields higher population diversity compared to novelty search.
Activation of LKB1-Akt Pathway Independent of Phosphoinositide 3-Kinase Plays a Critical Role in the Proliferation of Hepatocellular Carcinoma From Nonalcoholic Steatohepatitis (2010)

The SAMe-D cell line is a relevant model of HCC derived from NASH disease in which LKB1 is the principal conductor of a new regulatory mechanism and could be a practical tool for uncovering new therapeutic strategies.
Febrl - Freely extensible biomedical record linkage (2002)

This manual describes prototype software called Febrl designed to undertake probabilistic data cleaning (or standardisation) and record linkage. Written in the Python programming language, this software aims to allow health, biomedical and other researchers to clean (standardise) and link data sets of all sizes faster, with less effort and with improved quality. The authors would be grateful if users of Febrl would inform us (by e-mail) of how they have used the system. We are particularly interested in references to scientific papers or reports which mention or cite Febrl. Some suggested citations for Febrl will be provided in the next version of this manual.
Dependence of the conduction of a single biphenyl dithiol molecule on the dihedral angle between the phenyl rings and its application to a nanorectifier (2008)

The transport properties of a biphenyl dithiol (BPD) molecule sandwiched between two gold electrodes are studied using the nonequilibrium Green's function method based on the density functional theory. In particular, their dependence on the dihedral angle (phi=90 degrees -180 degrees ) between two phenyl rings is investigated. While the dihedral-angle dependence of the density of states projected on the BPD molecular orbitals is small, the transport properties change dramatically with phi. The transmission at the Fermi energy exhibits a minimum at phi=90.0 degrees and greatly increases with phi. The ratio of the maximum obtained at phi=180 degrees to the minimum exceeds 100. As an application of this characteristic transport behavior, a BPD molecule functionalized with NH(2) and NO(2) groups is considered. It is found that this molecule works as a nanorectifier.
An Efficient Rhodium(I) Initiator for Stereospecific Living Polymerization of Phenylacetylenes (1996)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTAn Efficient Rhodium(I) Initiator for Stereospecific Living Polymerization of PhenylacetylenesYasuhisa Kishimoto, Tatsuya Miyatake, Takao Ikariya, and Ryoji NoyoriView Author Information ERATO Molecular Catalysis Project, Research Development Corporation of Japan, 1247 Yachigusa, Yakusa-cho, Toyota 470-03, Japan Cite this: Macromolecules 1996, 29, 14, 5054–5055Publication Date (Web):July 1, 1996Publication History Received5 February 1996Revised24 April 1996Published online1 July 1996Published inissue 1 January 1996https://doi.org/10.1021/ma960180qCopyright © 1996 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views613Altmetric-Citations98LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (103 KB) Get e-AlertscloseSUBJECTS:Addition reactions,Gel permeation chromatography,Living polymerization,Polymerization,Polymers Get e-Alerts
Accurate micromethod of neonatal blood sampling from peripheral arterial catheters. (1995)

Blood sampling from peripheral arterial catheters is an important, but inadequately standardized, technique in neonatal intensive care. In this study two peripheral arterial sampling methods were evaluated in a neonatal animal model. One commonly used method (the drip technique) involves inserting a needle into the hub of the peripheral arterial catheter and discarding up to 10 drops of infusate fluid and blood before the sample is collected. This method was compared with a new micromethod where two needles are used (two-needle technique). Blood gas values in the peripheral samples were compared with control values drawn from a femoral artery catheter. Accuracy of peripheral arterial PCO2 and total blood loss constituted the final study variables. The results demonstrated that the two needle technique was more accurate, yielding peripheral arterial PCO2 values that were 98% of control values. Withdrawal of fewer than six drops of infusate fluid and blood with the drip technique resulted in spuriously low PCO2 values. The new technique also resulted in significantly less total blood loss per sample compared with the drip technique (189 +/- 3 microliters vs 398 +/- 3.8 microliters, mean +/- SEM, p < 0.01). We conclude that the two-needle micromethod is an accurate technique for blood sampling from peripheral arterial catheters and is particularly appropriate for low-birth-weight infants in whom minimization of blood loss is desirable.
Highly Crystalline Low Band Gap Polymer Based on Thieno[3,4-c]pyrrole-4,6-dione for High-Performance Polymer Solar Cells with a >400 nm Thick Active Layer (2015)

Two thieno[3,4-c]pyrrole-4,6-dione (TPD)-based copolymers combined with 2,2'-bithiophene (BT) or (E)-2-(2-(thiophen-2-yl)vinyl)thiophene (TV) have been designed and synthesized to investigate the effect of the introduction of a vinylene group in the polymer backbone on the optical, electrochemical, and photovoltaic properties of the polymers. Although both polymers have shown similar optical band gaps and frontier energy levels, regardless of the introduction of vinylene bridge, the introduction of a π-extended vinylene group in the polymer backbone substantially enhances the charge transport characteristics of the resulting polymer due to its strong tendency to self-assemble and thus to enhance the crystallinity. An analysis on charge recombination in the active layer of a solar cell device indicates that the outstanding charge transport (μ = 1.90 cm(2)·V(-1)·s(-1)) of PTVTPD with a vinylene group effectively suppresses the bimolecular recombination, leading to a high power conversion efficiency (PCE) up to 7.16%, which is 20% higher than that (5.98%) of the counterpart polymer without a vinylene group (PBTTPD). More importantly, PTVTPD-based devices do not show a large variation of photovoltaic performance with the active layer thickness; that is, the PCE remains at 6% as the active layer thickness increases up to 450 nm, demonstrating that the PTVTPD-based solar cell is very compatible with industrial processing.
Quality of Fruits and Vegetables in Home Handling Systems (2018)

The weakest link in the postharvest handling chain of fresh fruits and vegetables is the home handling system. When considered systematically as an integral part of the postharvest handling chain it becomes apparent that the home handling system is very complex. While the ultimate goal of delivering a quality fruit or vegetable to the mouth of the actual consumer may be true for both the postharvest handling chain and the home handling system, there are many differences between the two processes. Quality of fresh fruits and vegetables are evaluated by the home purchaser, the preparer and the consumer. The motivated purchaser/ preparer/ consumer has limited information on product history and few options for optimal storage of fresh fruits and vegetables in the home. More knowledge of home handling systems is essential for improved quality of fresh fruits and vegetables in the home.
Blood Transfusions and HIV Risk in Kumba, Cameroon (2006)

Studies of non-sexual risk factors for the spread of Human Immunodeficiency Virus (HIV) in central Africa have been limited. As blood transfusion is an extremely effective route for blood-borne infection, we examined transfusion practices in a town in northern Cameroon. We interviewed blood transfusion providers and transfusion recipients over a two-week period as to screening practices and knowledge of transfusion risk. We met with three transfusion centers and 13 patients and found that, although blood is currently screened for HIV, testing only became widespread in the mid 1990’s. Additionally, no screening is currently being done for hepatitis C, a prevalent disease in Central Africa. Although our study was small, we demonstrate that Cameroon has made improvements in securing their blood supply, but practices are far from ideal and have quite possibly contributed to the current Acquired Immunodeficiency Syndrome (AIDS) epidemic in Africa through years of untested transfusions.
Prion Pathogenesis in the Absence of NLRP3/ASC Inflammasomes (2015)

The accumulation of the scrapie prion protein PrPSc, a misfolded conformer of the cellular prion protein PrPC, is a crucial feature of prion diseases. In the central nervous system, this process is accompanied by conspicuous microglia activation. The NLRP3 inflammasome is a multi-molecular complex which can sense heterogeneous pathogen-associated molecular patterns and culminates in the activation of caspase 1 and release of IL 1β. The NLRP3 inflammasome was reported to be essential for IL 1β release after in vitro exposure to the amyloidogenic peptide PrP106-126 and to recombinant PrP fibrils. We therefore studied the role of the NLRP3 inflammasome in a mouse model of prion infection. Upon intracerebral inoculation with scrapie prions (strain RML), mice lacking NLRP3 (Nlrp3-/-) or the inflammasome adaptor protein ASC (Pycard-/-) succumbed to scrapie with attack rates and incubation times similar to wild-type mice, and developed the classic histologic and biochemical features of prion diseases. Genetic ablation of NLRP3 or ASC did not significantly impact on brain levels of IL 1β at the terminal stage of disease. Our results exclude a significant role for NLRP3 and ASC in prion pathogenesis and invalidate their claimed potential as therapeutic target against prion diseases.
A Distributed Algorithm for Optimal Vehicle Coordination at Traffic Intersecitons (2017)

Automated vehicle coordination can be used to control vehicles across traffic intersections safely and efficiently. This paper proposes a novel parallelizable algorithm, which solves the coordination problem at traffic intersections under a given precedence order by using a tailored variant of the augmented Lagrangian based alternating direction inexact Newton method (ALADIN). Here, each vehicle solves its own optimal control problem and exchanges information about arrivial and departure times at the intersection with its neighbors such that collisions are avoided. We illustrate the performance of ALADIN by analyzing two scenarios, one during rush hour and one at low-traffic conditions.
Long-term effects of Semliki Forest virus infection in the mouse central nervous system. (1997)

Semliki Forest virus (SFV) infection of mice is used as a model to study pathogenic processes occurring in viral encephalitis and demyelinating disease. In this study, the long-term effects of infection by the avirulent M9 mutant of SPV on the central nervous system (CNS) of BALB/c and SJL mice were determined. The presence of infectious virus, viral RNA and cytokine mRNA in the brains of individual mice and the presence of lesions in the spinal cords of the same mice up to 360 days post-infection (d.p.i.) were analysed in order to detect any correlation between these parameters of pathogenesis. Infectious virus could not be detected beyond 7 d.p.i. for either mouse strain. Reverse transcriptase polymerase chain reaction (RT-PCR) was used to detect the presence of the E2 and nsP1 regions of the virus genome and mRNA for interferon-gamma and tumour necrosis factor-alpha. Viral RNA could be detected up to 90 d.p.i. for both mouse strains. Cytokine mRNA could be detected up to 28 d.p.i. for BALB/c mice but up to 360 d.p.i. for SJL mice. Inflammatory lesions, which were associated with cytokine mRNA expression, were not detected in BALB/c mice beyond 28 d.p.i. but were detected in two SJL mice at 90 d.p.i. It is concluded that M9-SFV infection induces long-term prolonged expression of pro-inflammatory cytokines in the CNS of the majority of SJL (but not BALB/c) mice which is not associated with persistence of the virus genome. M9-SFV infection of SJL mice may be a relevant model for the pathogenesis of multiple sclerosis in man.
MobileRGBD, An Open Benchmark Corpus for mobile RGB-D Related Algorithms (2014)

International audience
Dynamic spectrum allocation with variable bandwidth for cognitive radio systems (2009)

Cognitive radio networks can be designed to manage the radio spectrum more efficiently by utilizing the spectrum holes in primary user's licensed frequency bands. The currently available unlicensed spectrum is reaching its limit and various demands for applications and data rates in wireless communications requires additional spectrum which imposes limits on spectrum access. These requirements demand for efficient and intelligent use of spectrum. The system model and the problem of the optimum spectrum allocation in cognitive radios are introduced and formulated. According to the Federal Communications Commission (FCC), cognitive radios are defined as radio systems that continuously perform spectrum sensing, dynamically identify unused spectrum, and then operate in those spectrum holes where the licensed (primary) radio systems are idle. In this way, spectrum utilization efficiency is dramatically enhanced. in this paper, For our CR system, we consider to the dynamic spectrum allocation (DSA).
Virtual Drive: A Complete V2X Communication and Radar System Simulator for Optimization of Multiple Antenna Systems (2011)

Vehicle-to-X (V2X) communication as well as automotive radar are fast growing areas of consumer interest. This gives rise to a challenge to a well-working communication systems in handling the V2X radio channel. The two most important components influencing the channel are the antennas and the fast changing environment, resulting in a time-variant behavior of the channel. Therefore, finding the optimal antenna configuration to ensure the best performance is a difficult task. A possible solution is the employment of measurement campaigns, but they are expensive, time consuming, and provide no repeatability. An alternative approach, based on simulations, is presented in this article. This tool, called “Virtual Drive,” consists of an environment and a traffic model and calculates the multipath propagation with a 3D ray-tracing tool. This combination yields a “virtual drive” through arbitrary scenarios and allows for the optimization of antenna configurations that are to be investigated. The different components of the Virtual Drive are described and the accuracy of the software tool is examined by a comparison with measurements. Finally, the manifold capabilities of such a software tool are demonstrated using the example of vehicular antenna optimization for cars and of radar system optimization.
德系犹太裔克罗恩病少儿患者与成年患者的NOD2/CARD15基因突变以及基因型-表现型相关性对比研究 (2005)

目的:NOD2/CARD15基因位点上的等位基因G908R、R702W和1007fs,与克罗恩病(CD)易感性之间存在显著而独立的相关性。笔者选择犹太裔CD患儿(≤16岁)和成年患者作为研究对象,比较分析两组患者NOD2/CARD15基因位点的基因型以及基因型-表现型相关性。方法:分析67例CD患儿和成年患者基因序列,采用等位基因特异性聚合酶链反应和限制性内切酶酶切反应,检测上述3个等位基因的携带率。同时,检测患者的表现型征象。结果:上述3个NOD2/CARD15 相关性等位基因的携带率,儿童组为51.1%,成年组为37.5%,两组间差异具有统计学显著性,P=0.07。G908R是最常见的等位基因,患儿组携带率为18%,成年患者组为11%,两组间差异具有统计学显著性,P= 0.063。德系犹太裔患儿的G908R等位基因携带率最高,远高于德系成年患者,两组的携带率分别为25%和9%,组间差异具有统计学显著性,P:0.003。患儿多有炎症性肠道疾患家族史,多患炎症性疾病,但与其携带的等位基因改变没有相关性。结论:德系犹太裔少儿幼年期发生的CD,与患儿NOD2/CARD15基因位点上出现G908R等位基因突变型存在密切的关联。
Integrin-targeted imaging and therapy with RGD4C-TNF fusion protein (2008)

This study used integrin alpha v beta3 as a target for tumor-specific delivery of tumor necrosis factor-alpha (TNF). The fusion protein RGD4C-TNF bound specifically to alpha v beta3 as evidenced by cell receptor binding assay and noninvasive micro-positron emission tomography imaging. 64Cu-DOTA-RGD4C-TNF had significantly higher activity accumulation in integrin-positive tumors (U87MG and MDA-MB-435) but not in integrin-negative tumors (C6) compared with 64Cu-DOTA-TNF. The magnitude of tumor uptake of 64Cu-DOTA-RGD4C-TNF correlated well with the alpha v beta3 level (U87MG > MDA-MB-435 > C6). Tumor accumulation of 64Cu-DOTA-RGD4C-TNF could be effectively blocked by c(RGDyK) peptide in alpha v beta3-positive tumor models, suggesting alpha v beta3 specificity of RGD4C-TNF fusion protein in vivo. Furthermore, although the fusion of RGD4C moiety to TNF had little effect on the bioactivity and cytotoxicity of RGD4C-TNF compared with TNF in cell culture, RGD4C-TNF was significantly more potent than TNF in inhibiting orthotopic MDA-MB-435 tumor growth. Ex vivo tissue staining confirmed specific cytotoxicity of RGD4C-TNF against integrin-positive tumor cells and tumor vasculature.