gebhart/patrepeval huggingface dataset:
Improvement of epileptic seizure control with treatment of obstructive sleep apnoea (2021)

Sleep deprivation increases the risk of recurrent seizures in epileptic patients. We identified 10 patients with recurrent seizures and sleep disruption related to obstructive sleep apnoea. Two patients were treated with positional therapy and the remaining eight patients were treated with continuous positive airway pressure. Three of the patients became seizure free and a fourth patient had a greater than 95% reduction in seizure frequency following only the initiation of therapy for the sleep apnoea. Three of these four patients responding to therapy, had a state-dependent seizure pattern. Two of the four responders did not exhibit the typical body habitus for obstructive sleep apnoea. Three additional patients improved in seizure frequency with change in anticonvulsant medication and treatment of the obstructive sleep apnoea. The remaining three patients had less than 50% reduction in seizure frequency with treatment of the obstructive sleep apnoea. These results indicate sleep disruption caused by sleep apnoea may increase the seizure frequency in some epileptic patients. Regardless of body habitus, epilepsy patients should be questioned carefully for a history of sleep disturbance and state dependence to their seizures. Treatment of sleep disorders in this population may lower the frequency of recurrent seizures.
“Disappearing” spinal cord compression: Oncolytic effect of glucocorticoids (and other chemotherapeutic agents) on epidural metastases (1977)

Four patients suffering spinal cord compression resulting from epidural metastases were treated with adrenocorticosteroid hormones. For 2 patients, prompt relief of symptoms followed glucocorticoid therapy alone and was associated with marked shrinkage or disappearance of the metastasis, a direct oncolytic effect of the steroids. For the other 2 patients, glucocorticoids combined with other chemotherapeutic agents caused disappearance of the extradural tumor. For 1 patient, failure to recognize the oncolytic effects of the chemotherapy led to an unnecessary surgical procedure, and for a second patient an unnecessary operation was narrowly averted. Thus, for certain patients, glucocorticoids may occasionally have a marked oncolytic effect on epidural metastatic tumors.
Very efficient plasma generation by whistler waves near the lower hybrid frequency (1984)

Experimental results are presented which show that r.f. power at frequencies near the lower hybrid frequency couples resonantly into a standing whistler wave. For an input power flux of less than 5 W cm-2 densities above 1012 cm-3 with close to 100% ionization have been achieved. Measured density, temperatures and wave fields are presented and are used as input parameters for a theoretical model.
Menopausal status and estrogen receptor genotypes influenced the severity of hot flashes after tamoxifen treatment (2005)

Background/Aims Hot flashes are the most common side effect of tamoxifen treatment. We conducted a prospective observational trial to evaluate factors that influenced hot flash severity after tamoxifen treatment. Methods Hot flashes frequency and severity were recorded in 7-day hot flashes diaries before, and 1, 4, 8, 12 months after tamoxifen treatment in 122 subjects. Hot flashes composit scores were calculated. Demographic information was collected at baseline, and estrogen receptor (ESR1 & 2) genotyping was also performed. Results Pre-menopausal women showed the biggest increase in hot flashes severity, from 5.2±10.5 at baseline to 28.5±51.6 at 4 month (P<0.0001), whereas there was no significant change in peri- or postmenopausal women. Twenty-two of the 122 women did not develop hot flashes. G allele carriers of the ESR2-02 SNP were 4.2 times more likely to develop hot flashes than homozygotes with AA genotype (P=0.008). Conclusion Pre-menopausal women were most likely to develop hot flashes after tamoxifen treatment. ESR2-02 genotype may also influence the risk of developing hot flashes after tamoxifen treatment. Clinical Pharmacology & Therapeutics (2005) 77, P4–P4; doi: 10.1016/j.clpt.2004.11.017
Experiences with Handheld Augmented Reality (2007)

In this paper, we present Studierstube ES, a framework for the development of handheld Augmented Reality. The applications run self-contained on handheld computers and smartphones with Windows CE. A detailed description of the performance critical tracking and rendering components are given. We also report on the implementation of a client-server architecture for multi-user applications, and a game engine for location based museum games that has been built on top of this infrastructure. Details on two games that were created, permanently deployed and evaluated in two Austrian museums illustrate the practical value of the framework and lessons learned from using it.
Visual and Vestibular Inputs Affect Muscle Synergies Responsible for Body Extension and Stabilization in Sit-to-Stand Motion (2019)

The sit-to-stand motion is a common movement in daily life and understanding the mechanism of the sit-to-stand motion is important. Our previous study shows that four muscle synergies can characterize the sit-to-stand motion, and they have specific roles, such as upper body flexion, rising from a chair, body extension, and posture stabilization. The time-varying weight of these synergies are changed to achieve adaptive movement. However, the relationship between sensory input and the activation of the muscle synergies is not completely understood. In this paper, we aim to clarify how vestibular and visual inputs affect the muscle synergy in sit-to-stand motion. To address this, we conducted experiments as follows. Muscle activity, body kinematics, and ground reaction force were measured for the sit-to-stand motion under three different conditions: control, visual-disturbance, and vestibular-disturbance conditions. Under the control condition, the participants stood without any intervention. Under the visual-disturbance condition, the participants wore convex lens glasses and performed the sit-to-stand motion in a dark room. Under the vestibular-disturbance condition, a caloric test was performed. Muscle synergies were calculated for these three conditions using non-negative matrix factorization. We examined whether the same four muscle synergies were employed under each condition, and the changes in the time-varying coefficients were determined. These experiments were conducted on seven healthy, young participants. It was found that four muscle synergies could explain the muscle activity in the sit-to-stand motion under the three conditions. However, there were significant differences in the time-varying weight coefficients. When the visual input was disturbed, a larger amplitude was found for the muscle synergy that activated mostly in the final posture stabilization phase of the sit-to-stand motion. Under vestibular-disturbance condition, a longer activation was observed for the synergies that extended the entire body and led to posture stabilization. The results implied that during human sit-to-stand motion, visual input has less contribution to alter or correct activation of muscle synergies until the last phase. On the other hand, duration of muscle synergies after the buttocks leave are prolonged in order to adapt to the unstable condition in which sense of verticality is decreased under vestibular-disturbance.
Tailoring entity resolution for matching product offers (2012)

Product matching is a challenging variation of entity resolution to identify representations and offers referring to the same product. Product matching is highly difficult due to the broad spectrum of products, many similar but different products, frequently missing or wrong values, and the textual nature of product titles and descriptions. We propose the use of tailored approaches for product matching based on a preprocessing of product offers to extract and clean new attributes usable for matching. In particular, we propose a new approach to extract and use so-called product codes to identify products and distinguish them from similar product variations. We evaluate the effectiveness of the proposed approaches with challenging real-life datasets with product offers from online shops. We also show that the UPC information in product offers is often error-prone and can lead to insufficient match decisions.
Selection of Conductive Additives in Li-Ion Battery Cathodes (2007)

The lithium-ion cell has been successively improved with adoption of new cathode electrochemistries, from to higher-capacity to lower cost . The addition of conductive additives to cathode materials has been demonstrated to improve each type. Four systems have emerged as important cathodes in recent studies: (i) the spinel , (ii) , (iii) the "Gen 2" material, , and (iv) the system. The architectures of model composite cathodes were generated using our prior approach in simulating packing of polydisperse arrangements; conductivity was then simulated for several realizations of each case. A key finding was that the conductive coatings significantly improve overall conductivity. Percolation was achieved for the volume fraction of active material in studied cases, which was larger than the percolation threshold for a 3D spherical particulate system. Neither surface nor bulk modifications of active-material particle conductivities seem desirable targets for improvement of laminate conductivity at present. As part of future work, trade-offs between conductivity and capacity will be considered.
Purification and Partial Characterization of a Unique Group of Phosphoproteins from Rat Milk Whey (1978)

A group of four electrophoretically distinct but related proteins has been isolated from rat milk whey. These have been classified as P.1 to P.4 in order of their decreasing electrophoretic mobility in an alkaline buffer system. All four members of this group of proteins are immunologically identical and apparently constitute a single protein which is differentially phosphorylated in the ratio of 3 : 2:1:0. Sodium dodecyl sulfate gel electrophoresis yielded constant estimates of molecular weight of approximately 20,700. Enzymatic dephosphorylation of purified P.1 generated the other three members of the group, demonstrating the commonality of the peptide component. This group of proteins in total makes a significant contribution to the total whey proteins being approximately 5 mg/ml in whole rat milk in the approximate proportion of 1:i.5:2:1,5. The P.1, P.2, and P.3 were isolated in sufficient quantities to permit further characterization. The partial amino acid analyses of each of the three forms were similar. They had common extinction coefficients, El% cm A2s0, of 4.9 and Aes0/A290 ratios of about 1.36
The Involvement of a Ca2+Channel Blocking Mode of Action in the Pharmacology ofAmmi visnagaFruits1 (1994)

Based on a screening program of medicinal plants for their possible calcium antagonistic mode of action, the most active lipophilic extract of Ammi visnaga fruits (DAB 10) was fractionated by CC and investigated pharmacologically at K+ (60 mM)-depolarized guinea-pig aortic strips. Visnadin, khellin, and visnagin were identified and determined as the effective principles in this testing model with the dihydropyranocoumarin visnadin being the most active. Further selectivity tests against norepinephrine (100 microM)-induced contractions evaluated a possible pharmacological differentiation between these compounds as the furanochromones khellin and visnagin inhibited both spasms to a similar extent while visnadin's activity was significantly higher against K(+)-spasms, suggesting an involvement of a calcium channel blocking mode of action for visnadin.
Maximum Bladed Disk Forced Response From Distortion of a Structural Mode (2003)

A method is presented for obtaining maximum bladed disk forced response from distortion of a structural mode. It is shown that maximum response from mode distortion in a bladed disk occurs when the harmonic components of a distorted mode superimpose in a certain manner, causing localization of the mode and strong response in a particular blade. In addition, it is shown that the response of an intentionally mistuned system with maximum response does not change significantly when small random mistuning is added to the system. A method is described for calculating the structural mistuning necessary to obtain the distorted mode that gives maximum response. The theory is validated numerically.
Evaluation of information leak by robustness evaluation of countermeasure to disguised CSI in PLNC considering physical layer security (2015)

In Physical Layer Network Coding (PLNC), the two information sources access to the relay station, simultaneously and thus the transmitted signals are combined, together. Since the relay station hardly decodes each information single, the security for avoiding the information leak to the relay station is maintained. Therefore, the PLNC is attracting much attention in terms of physical layer security (PLS). However, the information source needs the transmit power control based on the channel state information (CSI). If the relay station is untrusted, it camouflages the real CSI for stealing the information. This paper considers the camouflaging of CSI is modeled as the liner programming problem in the subject to the statistic of CSI following the model of propagation. We clarify the maximal capacity of tapping by the relay station.
Isolation, Culture, and Characterization of Primary Schwann Cells, Keratinocytes, and Fibroblasts from Human Foreskin (2022)

This protocol describes isolation methods, culturing conditions, and characterization of human primary cells with high yield and viability using rapid enzymatic dissociation of skin. Primary keratinocytes, fibroblasts, and Schwann cells are all harvested from the human newborn foreskin, which is available following standard of care procedures. The removed skin is disinfected, and the subcutaneous fat and muscle are removed using a scalpel. The method consists of enzymatic and mechanical separation of epidermal and dermal layers, followed by additional enzymatic digestion to obtain single-cell suspensions from each of these skin layers. Finally, single cells are grown in appropriate cell culture media following standard cell culture protocols to maintain growth and viability over weeks. Together, this simple protocol allows isolation, culturing, and characterization of all three cell types from a single piece of skin for in vitro evaluation of skin-nerve models. Additionally, these cells can be used together in co-cultures to gauge their effects on each other and their responses to in vitro trauma in the form of scratches performed robotically in the culture associated with wound healing.
Low cost cloud based remote microscopy for biological sciences (2021)

A low cost remote imaging platform for biological applications was developed. The “Picroscope” is a device that allows the user to perform longitudinal imaging studies on multi-well cell culture plates. Here we present the network architecture and software used to facilitate communication between modules within the device as well as system communication with external cloud services. A web based console was created to control the device and view experiment results. Post processing tools were developed to analyze captured data in the cloud. The result is a platform for monitoring biological experiments from outside the lab.
Medical school and career performances of medical students with low medical college admission test scores (1967)

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Lighting on snowplows : an accident countermeasure? (2001)

Improvements to the lighting systems on snowplows could make the vehicles' safer, possibly reducing accident rates. Studies have found that glare can be reduced when narrow beams are used and when mounting positions are as far as possible from the line of sight. For instance, auxiliary headlamps mounted on the sides of vehicles are low-cost ways to reduce glare. While flashing and strobing lights can draw attention to a snow plow, studies have found that steady-burning lights are more effective in alerting other drivers to the truck's relative speed and distance as other drivers approach it from behind.
Nickel-Catalyzed Site-Selective Alkylation of Unactivated C(sp3)–H Bonds (2014)

The direct alkylation of unactivated sp(3) C-H bonds of aliphatic amides was achieved via nickel catalysis with the assist of a bidentate directing group. The reaction favors the C-H bonds of methyl groups over the methylene C-H bonds and tolerates various functional groups. Moreover, this reaction shows a predominant preference for sp(3) C-H bonds of methyl groups via a five-membered ring intermediate over the sp(2) C-H bonds of arenes in the cyclometalation step.
Measurement of the vector character of electric fields by optical second-harmonic generation (1999)

We present a scheme for the determination of the vector nature of an electric field by optical second-harmonic generation. We demonstrate the technique by mapping the two-dimensional electric-field vector of a biased transmission line structure on silicon with a spatial resolution of ~10mum .
The homing flight ring test: method for the assessment of sublethal doses of plant protection products on the honey bee in field condition (2018)

International audience
Under-optimized smart contracts devour your money (2017)

Smart contracts are full-fledged programs that run on blockchains (e.g., Ethereum, one of the most popular blockchains). In Ethereum, gas (in Ether, a cryptographic currency like Bitcoin) is the execution fee compensating the computing resources of miners for running smart contracts. However, we find that under-optimized smart contracts cost more gas than necessary, and therefore the creators or users will be overcharged. In this work, we conduct the first investigation on Solidity, the recommended compiler, and reveal that it fails to optimize gas-costly programming patterns. In particular, we identify 7 gas-costly patterns and group them to 2 categories. Then, we propose and develop GASPER, a new tool for automatically locating gas-costly patterns by analyzing smart contracts' bytecodes. The preliminary results on discovering 3 representative patterns from 4,240 real smart contracts show that 93.5%, 90.1% and 80% contracts suffer from these 3 patterns, respectively.
Critical current versus magnetic flux characteristic of DC tunnel SQUIDS (1981)

Investigations of the critical current versus magnetic flux characteristics of dc-tunnel SQUIDS in dependence on the value of LIcm/Φ0 are carried out. The influence of the asymmetry of current feeding into the SQUID loop is discussed and compared with experiments. The behavior of the SQUID in the low damped case is experimentally investigated with the effect of multiple critical currents. The probabilities of the different critical currents of the periodically biased SQUID are measured in dependence on the magnetic flux. Es werden Untersuchungen zum kritischen Strom in Abhängigkeit vom magnetischen Fluß von dc-Tunnel-SQUIDs als Funktion der Größe LIcm/Φ0 durchgeführt. Der Einfluß der Asymmetrie der Stromeinspeisung wird diskutiert und mit Experimenten verglichen. Weiterhin wird das Ver-halten des SQUIDs im schwach gedämpften Fall experimentell an der Mehrdeutigkeit des kritischen Stromes bei periodischer Stromspeisung untersucht. Die Häufigkeiten von verschiedenen kritischen Strömen bei periodischer Ansteuerung des SQUIDs werden in Abhängigkeit vom megnetischen Fluß gemessen.
Epigenetic transfer of metastatic activity by uptake of highly metastatic B16 melanoma cell-released exosomes. (2006)

The metastatic activity of highly metastatic BL6-10 tumor cells can be transferred to poorly metastatic F1 tumor cells by uptake of highly metastatic BL6-10 tumor-released EXO.
The Quadrics network (QsNet): high-performance clustering technology (2002)

The Quadrics interconnection network (QsNet) contributes two novel innovations to the field of high-performance interconnects: (I) integration of the virtual-address spaces of individual nodes into a single, global, virtual-address space and (2) network fault tolerance via link-level and end-to-end protocols that can detect faults and automatically re-transmit packets. QsNet achieves these feats by extending the native operating system in the nodes with a network operating system and specialized hardware support in the network interface. As these and other important features of QsNet can be found in the InfiniBand specification, QsNet can be viewed as a precursor to InfiniBand. In this paper, we present an initial performance evaluation of QsNet. We first describe the main hardware and software features of QsNet, followed by the results of benchmarks that we ran on our experimental, Intel-based, Linux cluster built around QsNet. Our initial analysis indicates that QsNet performs remarkably well, e.g., user-level latency under 2 /spl mu/s and bandwidth over 300 MB/s.
Caveolar domain organization and trafficking is regulated by Abl kinases and mDia1 (2012)

The biology of caveolin-1 (Cav1)/caveolae is intimately linked to actin dynamics and adhesion receptors. Caveolar domains are organized in hierarchical levels of complexity from curved or flattened caveolae to large, higher-order caveolar rosettes. We report that stress fibers controlled by Abl kinases and mDia1 determine the level of caveolar domain organization, which conditions the subsequent inward trafficking of caveolar domains induced upon loss of cell adhesion from the extracellular matrix. Abl-deficient cells have fewer stress fibers, a smaller pool of stress-fiber co-aligned Cav1 and increased clustering of Cav1/caveolae at the cell surface. Defective caveolar linkage to stress fibers prevents the formation of big caveolar rosettes upon loss of cell adhesion, correlating with a lack of inward trafficking. Live imaging of stress fibers and Cav1 showed that the actin-linked Cav1 pool loses its spatial organization in the absence of actin polymerization and is dragged and clustered by depolymerizing filaments. We identified mDia1 as the actin polymerization regulator downstream of Abl kinases that controls the stress-fiber-linked Cav1 pool. mDia1 knockdown results in Cav1/caveolae clustering and defective inward trafficking upon loss of cell adhesion. By contrast, cell elongation imposed by the excess of stress fibers induced by active mDia1 flattens caveolae. Furthermore, active mDia1 rescues the actin co-aligned Cav1 pool and Cav1 inward trafficking upon loss of adhesion in Abl-deficient cells. Thus, caveolar domain organization and trafficking are tightly coupled to adhesive and stress fiber regulatory pathways.