gebhart/patrepeval huggingface dataset:
Isolation and Identification of a Novel Anti-protein Aggregation Activity of Lignin-Carbohydrate Complex From Chionanthus retusus Leaves (2020)

Lignin-carbohydrate complex (LCC) is the biological macromolecule that has been demonstrated to exert multiple biological functions, including antioxidant, anti-inflammation and anti-tumorigenesis, which support its broad application in the bioengineering field. However, it remains elusive the involvements of LCC in human neurological disorders, especially those with the overproduction of reactive oxygen species (ROS), such as spinocerebellar ataxias (SCAs). In this study, we found a previously undetermined anti-protein aggregation activity of LCC. Initially, two individual LCC preparations and carbohydrate-free lignin were isolated from the water-extracted waste residues of <i>Chionanthus retusus</i> (<i>C. retusus</i>) tender leaves. The chemical compositional analysis revealed that lignin (61.5%) is the predominant constituent in the lignin-rich LCC (LCC-L-CR), whereas the carbohydrate-rich LCC (LCC-C-CR) is mainly composed of carbohydrate (60.9%) with the xylan as the major constituent (42.1%). The NMR structural characterization showed that LCC-L-CR preparation is enriched in benzyl ether linkage, while phenyl glycoside is the predominant type of linkage in LCC-C-CR. Both LCC and lignin preparations showed antioxidant activities as exemplified by their abilities to scavenge free radicals in cultured mammalian cells and ROS in zebrafish. We further demonstrated a pronounced capability of LCC-L-CR in inhibiting the aggregation of expanded Ataxin-3, disease protein of SCA type 3, in human neuronal cells. Taken together, our study highlights the antioxidant and novel anti-protein aggregation activities of the <i>C. retusus</i> tender leaves-derived LCC.
Compact Lensless Fluorescence Counting System for Single Molecular Assay (2018)

In digital enzyme-linked immunosorbent assay, which is used for biomarker detection and diagnosis, the concentration of target biomarkers is estimated by counting the number of fluorescence chambers in the microchamber array. We propose a compact system for counting fluorescent chambers. Our system consists of three components: a micro-reaction chamber array, an absorption filter for attenuating excitation light, and a photodetector. The absorption filter has a micro-light-pipe array (m-LPA) structure. A stacked photodiode CMOS image sensor (CIS), which can discriminate color, is applied as a photodetector. This paper describes the fabrication process enabling thin m-LPA chips. The unique low-noise characteristics of the stacked photodiode CIS that attains high sensitivity by adopting the 4T-APS configuration are explained. Furthermore, a detection method using the photobleaching phenomenon is proposed for high-sensitivity fluorescence detection. This method suggests that fluorescence by a single molecular enzyme can be detected within 30 min of the start of the fluorescence reaction.
Accutin, a New Disintegrin, Inhibits Angiogenesis In Vitro and In Vivo by Acting as Integrin vβ3 Antagonist and Inducing Apoptosis (1998)

Endothelial integrins play an essential role in angiogenesis and cell survival. Accutin, a new member of disintegrin family derived from venom of Agkistrodon acutus, potently inhibited human platelet aggregation caused by various agonists (eg, thrombin, collagen, and, adenosine diphosphate [ADP]) through the blockade of fibrinogen binding to platelet glycoprotein IIb/IIIa (ie, integrin alphaIIbbeta3). In this report, we describe that accutin specifically inhibited the binding of monoclonal antibody (MoAb) 7E3, which recognizes integrin alphavbeta3, to human umbilical vein endothelial cells (HUVECs), but not those of other anti-integrin MoAbs such as alpha2beta1, alpha3beta1, and alpha5beta1. Moreover, accutin, but not the control peptide GRGES, dose-dependently inhibited the 7E3 interaction with HUVECs. Both 7E3 and GRGDS, but not GRGES or Integrelin, significantly blocked fluorescein isothiocyanate-conjugated accutin binding to HUVEC. In functional studies, accutin exhibited inhibitory effects on HUVEC adhesion to immobilized fibrinogen, fibronectin and vitronectin, and the capillary-like tube formation on Matrigel in a dose- and RGD-dependent manner. In addition, it exhibited an effective antiangiogenic effect in vivo when assayed by using the 10-day-old embryo chick CAM model. Furthermore, it potently induced HUVEC apoptotic DNA fragmentation as examined by electrophoretic and flow cytometric assays. In conclusion, accutin inhibits angiogenesis in vivo and in vitro by blocking integrin alphavbeta3 of endothelial cells and by inducing apoptosis. The antiangiogenic activity of disintegrins might be explored as the target of developing the potential antimetastatic agents.
The Study on Modern Technology System of Henan Province (2009)

By comparing the present situation,scale and structure of Henan Province with the concerning targets home and abroad and using AHP as well as the method of comparative analysis,this paper has carried out the systematic evaluation on the modern agricultural technology system and put forward a new structure along with policy suggestions about support measure related to modern agricultural technology system construction.
Machine Learning for Optimal Copper Doping Profile Design in CdTe Solar Cells (2021)

In this work we use machine learning to extract actual Cu doping profiles that result from the process of diffusion annealing and cool-down in the fabrication sequence of CdTe solar cells. We use two deep learning neural network models (Artificial Neural Network (ANN) model using a Keras API with TensorFlow backend and a Radial Basis Function Network (RBFN) model) to predict the Cu doping profiles for different temperatures and duration of the annealing process. We find excellent agreement between the simulated results obtained with the PVRD-FASP Solver and predicted values. It takes significant amount of time to generate with the PVRD-FASP Solver the Cu doping profiles given the initial conditions. The generation of the same with machine learning is almost instantaneous and can serve as an excellent simulation tool to guide future fabrication of optimal doping profiles in CdTe solar cells.
Persistency of excitation and overparametrization in model reference adaptive control (1990)

The problem of overparameterization of the plant in model reference adaptive control (MRAC) is analyzed. Overparametrization may arise when an upper bound for the order of the plant is used in the design of the MRAC or when the transfer function of the modeled part of the plant has common zeros and poles. It is shown that under parametrization the parameters for model-plant transfer function matching lie in a linear variety. If the reference input signal has enough frequencies, the estimated parameters will converge to this variety. In the presence of modeling errors such as bounded disturbances, the parameters may drift to infinity along the linear variety independently of the number of frequencies in the reference input signal. In the case of exact parameterization but close zero-pole cancellation, the signal vector is shown to be persistently exciting with a low level of excitation. Such a low level of excitation may lead to poor rate of convergence and to loss of robustness with respect to modeling errors.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
First direct evidence for the mechanism of .DELTA.1-tetrahydrocannabinolic acid biosynthesis (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFirst direct evidence for the mechanism of .DELTA.1-tetrahydrocannabinolic acid biosynthesisFutoshi Taura, Satoshi Morimoto, Yukihiro Shoyama, and Raphael MechoulamCite this: J. Am. Chem. Soc. 1995, 117, 38, 9766–9767Publication Date (Print):September 1, 1995Publication History Published online1 May 2002Published inissue 1 September 1995https://pubs.acs.org/doi/10.1021/ja00143a024https://doi.org/10.1021/ja00143a024research-articleACS PublicationsRequest reuse permissionsArticle Views1338Altmetric-Citations142LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Metabolic factors affecting hepatocellular carcinoma in steatohepatitis (2018)

We report the largest single-center study evaluating clinical, histopathological and outcome measures of patients undergoing liver transplantation for steatohepatitis. Older patients, diabetics, and Hispanics may warrant more frequent cancer screening due to increased risk of hepatocellular carcinoma.
Nanoscale-Controlled Spacing Provides DNA Microarrays with the SNP Discrimination Efficiency in Solution Phase (2005)

We have prepared solid substrates modified with a cone-shaped dendron that generates mesospacing (3.2 nm on average) on the surface. This nanoscale-controlled surface provided an ideal DNA microarray in which each probe DNA strand was given ample space for the incoming target DNA, resulting in selectivity as high as that in solution (100: < 1). In addition, high hybridization yield confirms that DNA probes on the mesospaced surface are sterically unhindered for the hybridization.
Towards Semantic Understanding of Surrounding Vehicular Maneuvers: A Panoramic Vision-Based Framework for Real-World Highway Studies (2016)

This paper proposes the use of multiple low-cost visual sensors to obtain a surround view of the ego-vehicle for semantic understanding. A multi-perspective view will assist the analysis of naturalistic driving studies (NDS), by automating the task of data reduction of the observed sequences into events. A user-centric vision-based framework is presented using a vehicle detector and tracker in each separate perspective. Multi-perspective trajectories are estimated and analyzed to extract 14 different events, including potential dangerous behaviors such as overtakes and cut-ins. The system is tested on ten sequences of real-world data collected on U. S. highways. The results show the potential use of multiple low-cost visual sensors for semantic understanding around the ego-vehicle.
Synthesis and Properties of Novel Bis(1,3-benzodithiolium)-Type Dications Containing a Biaryl Unit: New Redox Systems Undergoing Reversible Structural Changes by Electron Transfer (2006)

In order to develop new redox systems which undergo reversible structural changes by electron transfer, bis(1,3-benzodithiolium)-type dications (5 2+ ) containing a biaryl unit have been synthesized by hydride abstraction of the corresponding bis(1,3-benzodithiol-2-yl)biaryls (8).Reduction of 5 2+ with zinc gave the corresponding intramolecular cyclization products (6), which reverted to 5 2+ by oxidation.Cyclic voltammetry also showed the efficient interconversion between both states.X-Ray analyses revealed that the twist angle of the biaryl unit decreases largely by reductive intramolecular cyclization.
ANTIOXIDATIVE EFFECTS OF SESAMIN DURING HIGH INTENSITY EXERCISE (2003)

Sesamin is one of the lignans existing exclusively and abundantly in sesame oil. It is generally agreed that sesamin has no antioxidative activity in vitro, but can be metabolized to a strong antioxidant in liver. PURPOSE Protective effects of sesamin against exercise-induced lipid peroxidation were examined in humans and animals during a prolonged high intensity exercise. METHODS In human experiment, seven male university students were asked to perform 30 min of ergometer exercise at an intensity corresponding to 80–90% of each individual predicted HRmax. Placebo, sesamin and vitamin E capsules were randomly administered to the subjects. Each subject orally ingested the sample 2 hours before exercise. Blood samples were collected before, 5, 10 and 20 min after the exercise and during the recovery. Lipid peroxides (LPO) in plasma was measured by Hb-MB method. RESULTS In P trial, LPO values significantly increased after 10 and 20 min of exercise compared to the resting condition. And LPO returned to the resting level immediately after exercise. To further investigate the antioxidative effects of sesamin, sixty-four male ddY mice were divided into two groups and the four subgroups. The mice in exercise groups were subjected to swimming exercise in an aquarium tank 2 h after the sample administration. Exercise resulted in a significant increase in LPO in control and vitamin E trial but not in sesamin trial. Sesamin was shown to enhance total glutathione peroxidase (GPX) activity and glutathione S-transferase (GST) activity. Vitamin E treatment did not significantly change any of these LPO metabolizing enzymes activities. CONCLUSION Sesamin might be considered as a strong LPO suppressor in humans and animal experiments.
Test vector chains for increasing the fault coverage and numbers of detections (2009)

The authors introduce the concept of test vector chains which allows one to obtain new test vectors from existing ones through single-bit changes. A test vector chain is defined based on a pair of test vectors t1 and t2. It consists of a sequence of single-bit changes, which gradually modifies t1 into t2. The authors demonstrate that, based on a test set T that does not detect all the detectable target faults, it is possible to define a significant number of test vector chains, which are effective in detecting yet-undetected target faults. It is also possible to find test vector chains that are effective in increasing the numbers of detections of target faults that are detected by T. Increasing the number of detections increases the coverage of untargeted faults, that is, faults that were not targeted during the generation of T. The authors study criteria for identifying the most effective test vector chains of a test set in order to avoid considering m(m−1) test vector chains for a test set of size m, and describe test generation procedures based on test vector chains.
Condición física, percepción subjetiva del esfuerzo y rendimiento académico en educación primaria (2019)

Existen estudios que han conseguido establecer una relación entre el rendimiento cognitivo y académico de los alumnos y sus niveles de condición física. Los objetivos de esta investigación son estudiar la correlación existente entre el nivel de condición física y la composición corporal con el rendimiento académico, así como analizar la correlación entre dichas variables y la percepción subjetiva del esfuerzo (RPE) por género en alumnos de Educación Primaria. Un total de 69 alumnos de Educación Primaria participaron en el estudio (edad= 12,33±0,47 años, 55,9% niñas y 44,1% niños). La condición física y la composición corporal se evaluaron siguiendo los test de la ALPHA Fitness test Battery para niños y adolescentes. El rendimiento académico se estudió mediante el promedio de notas de las asignaturas instrumentales de Educación Primaria. La RPE se registró en las clases de EF y actividades físicas escolares mediante el uso de la escala RPE de Borg (0-10). Se establecieron correlaciones significativas entre la RPE y el peso de los chicos (r= 0,406, p= 0.02) y las chicas (r= 0,643, p&lt; 0.001) y también con respecto al IMC, chicos (r= 0,508, p= 0.004), chicas (r= 0,621, p&lt; 0.001). Existió una correlación negativa significativa entre el test de la Course Navette y la RPE en el caso de los niños (r= -0,633, p&lt; 0.001) y de las niñas (r= -0,452, p= 0.004). La RPE se correlacionó significativamente con los palieres del test de Course Navette (correlación inversa) y las variables antropométricas, como son el peso y el IMC.
6. IL-6 Inhibitors for Treatment of Rheumatoid Arthritis (2008)

関節リウマチ（rheumatoid arthritis，RA）の病態形成に，炎症性サイトカインであるインターロイキン-6（interleukin-6，IL-6）の過剰産生がかかわっている．トシリズマブ（tocilizumab）は，ヒト化抗IL-6受容体モノクローナル抗体であり，RAの炎症症状のみならず，関節破壊の進行を抑える．トシリズマブは日本で開発された最初の抗体医薬であり，世界に先駆けて本年4月にRAに対し承認された．
A SIMPLE METHOD OF EVACUATING SMOKE FROM WOUNDS (1989)

Division of Plastic Surgery Washington University School of Medicine Suite 17424 East Pavilion One Barnes Hospital Plaza St. Louis, Mo. 63110
Supplementary Figure 11 from Oxygen-enhanced MRI Is Feasible, Repeatable, and Detects Radiotherapy-induced Change in Hypoxia in Xenograft Models and in Patients with Non–small Cell Lung Cancer (2023)

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Determination of Bisbibenzyls in Bryophytes Collected from Different Locations by RP-HPLC (2009)

AIM: To develop a rapid high-performance liquid chromatographic method for the determination of bisbibenzyls in four bryophytes. The effects of species and sample locations on the bisbibenzyl composition and content were also evaluated. METHOD: Chromatographic separation was achieved on a Hypersil C18 column (150 mm × 4.6 mm, I.D. 5 μm) with acetonitrile-water gradient elution (each containing 0.05% formic acid). UV detection was performed at 280 nm. RESULTS: A total of 6 bisbibenzyls were detected in four bryophytes, and the results show that the sample locations and species have an influence on the bisbibenzyl composition and the content of each bisbibenzyl. CONCLUSION: This method not only provides a useful tool for analyzing and quantifying the bisbibenzyls but also provides useful information on the phytochemical research of these bryophytes.
The Prins Reaction (1977)

The acid-catalysed olefin-aldehyde condensation, known as the Prins reaction, is briefly reviewed in order to present some of the more important aspects of this synthetically useful reaction. This reaction can be used to prepare 1,3-dioxanes, 1,3-glycols, unsaturated alcohols, diolefins, or chloroethers from simple olefins and formaldehyde in the presence of an acid. Reactions of hetero-substituted olefins lead to the correspondingly substituted 1,3-dioxanes, unsaturated acids or esters, or dihydropyrans. Reactions of diolefins lead to product mixtures, depending on the reaction conditions. 1. Reaction of Simple Olefins 1.1. Preparation of 1,3-Dioxanes 1.2. Preparation of 1,3-Glycols, Unsaturated Alcohols, and Diolefins 1.3. Preparation of Chloroethers 2. Reaction of Substituted Olefins 2.1. Reaction of Aryl-Substituted Olefins 2.2. Reaction of Halogen-Substituted Olefins 2.3. Reaction of Hydroxy-Substituted Olefins 2.4. Reaction of Terpenes and Cyclic Olefins 3. Reaction of Dienes
Cruising is Believing?: Comparing Internet and Traditional Sources on Media Credibility Measures (1998)

This study surveyed politically-interested Web users online to examine whether they view Web publications as credible as their traditionally- delivered counterparts. Credibility is crucial for the Internet because past studies suggest people are less likely to pay attention to media they do not perceive as credible. This study found online media tended to be judged more credible than their traditional versions. However, both online and traditional media were only judged as somewhat credible.
Camera Distance-Aware Top-Down Approach for 3D Multi-Person Pose Estimation From a Single RGB Image (2019)

Although significant improvement has been achieved recently in 3D human pose estimation, most of the previous methods only treat a single-person case. In this work, we firstly propose a fully learning-based, camera distance-aware top-down approach for 3D multi-person pose estimation from a single RGB image. The pipeline of the proposed system consists of human detection, absolute 3D human root localization, and root-relative 3D single-person pose estimation modules. Our system achieves comparable results with the state-of-the-art 3D single-person pose estimation models without any ground truth information and significantly outperforms previous 3D multi-person pose estimation methods on publicly available datasets. The code is available in <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1,2</sup> .
Observation of Faraday rotation from a single quantum-dot spin (2007)

Here, we present an all-optical dispersive measurement of a single spin confined in a self-assembled InAs/GaAs quantum dot (QD) (Atature etl., 2007). The time-averaged spin-state is observed via spin-dependent Faraday rotation of a spectrally detuned laser, induced by the polarization-and spin-selective trion transitions. The measurement was performed with a spin prepared by an independent laser (Atature et al., 2006) and in the case of a thermal state.
Ureteroscopic and Radiographic Imaging of the Upper Urinary Tract (1998)

Direct endoscopic viewing of the upper urinary tract offers multiple benefits, including recognition and diagnosis, and also permits unsurpassed accuracy in positioning working instruments for biopsy and treatment. We have demonstrated the normal and abnormal endoscopic findings within the upper urinary tract in patients who were treated ureteroscopically for numerous indications, including calculi, filling defects, or ureteral obstruction. Small (7 to 7.5F) rigid and flexible ureteroscopes were employed in all patients. Selected endoscopic images of the subject lesions were photographed using a 35-mm camera with an endoscopic zoom lens and ISO-400 film. Endoscopic findings are illustrated in 13 patients, with case summaries in 11. Selected radiographic and endoscopic images show the essential features in each case and demonstrate the value of ureteroscopic examination.
Raman spectroscopic investigation of spinal cord injury in a rat model (2011)

Raman spectroscopy was used to study temporal molecular changes associated with spinal cord injury (SCI) in a rat model. Raman spectra of saline-perfused, injured, and healthy rat spinal cords were obtained and compared. Two injury models, a lateral hemisection and a moderate contusion were investigated. The net fluorescence and the Raman spectra showed clear differences between the injured and healthy spinal cords. Based on extensive histological and biochemical characterization of SCI available in the literature, these differences were hypothesized to be due to cell death, demyelination, and changes in the extracellular matrix composition, such as increased expression of proteoglycans and hyaluronic acid, at the site of injury where the glial scar forms. Further, analysis of difference spectra indicated the presence of carbonyl containing compounds, hypothesized to be products of lipid peroxidation and acid catalyzed hydrolysis of glycosaminoglycan moieties. These results compared well with in vitro experiments conducted on chondroitin sulfate sugars. Since the glial scar is thought to be a potent biochemical barrier to nerve regeneration, this observation suggests the possibility of using near infrared Raman spectroscopy to study injury progression and explore potential treatments ex vivo, and ultimately monitor potential remedial treatments within the spinal cord in vivo.