gebhart/patrepeval huggingface dataset:
Purification and some properties of 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid(HOPDA) reducing enzyme from Pseudomonas cruciviae S93B1 involved in the degradation of biphenyl. (1986)

Pseudomonas cruciviae S93B1 produced three HOPDA reducing enzymes (I, II, III), found by chromatography on DEAE-Sepharose CL-6B. The purified HOPDA reducing enzyme III was homogeneous on polyacrylamide gel and has a mol. wt. of about 170, 000 by Sephadex G-200. The reducing enzyme III produced 2, 6-dioxo-6-phenylhexanoic acid from HOPDA. NADPH was an essential cofactor for HOPDA reducing enzyme III. The enzyme was stable between pH 5 and 7. The ring-fission products from biphenyl-2, 3-diol, 3-isopropylcatechol, 3-methylcatechol and the methyl ester of HOPDA were substrates for the reducing enzymes I, II and III. The ring-fission products from 3-methoxycatechol and catechol served as substrates for reducing enzymes I and II. The methyl ester of HOPDA was reduced by reducing enzyme III to 2-methoxy-6-oxo-6-phenylhexa-2-enoic acid methyl ester.
Development of DNA Analysis for Human Diseases (1992)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tissue and nitrogen-linked expression profiles of ammonium and nitrate transporters in maize (2019)

These data allowed the mapping of putative nitrogen transporters in maize at both the vegetative and reproductive stages of development. No growth-dependent expression was seen in our conditions. We found that nitrogen transporter genes were expressed in all the organs tested and in many cases were regulated by the availability of nitrogen supplied to the plant. The gene expression patterns in relation to organ specificity and nitrogen availability denote a speciality of nitrate and ammonium transporter genes and their probable function depending on the plant organ and the environment.
Two-photon intravital imaging of leukocyte migration during inflammation in the respiratory system (2019)

Two-photon intravital imaging is a powerful method by which researchers are able to directly observe biological phenomena in live organisms. Researchers in various biomedical research fields have applied two-photon imaging to a variety of target organs by utilizing this technology's ability to penetrate to significant depths with minimal phototoxicity. The mouse respiratory system in inflammation models is a good example, as two-photon intravital imaging can provide insights as to how the immune system is activated in response to inflammation within the respiratory system. Inflammation models can be generated via influenza viral, bacterial, or lipopolysaccharide injection. To exteriorize the lungs or trachea, thoracotomy or tracheotomy is performed, respectively; the appropriate combination of inflammation induction and organ exposure is selected depending on the study purpose. On the other hand, visualizing the movement of leukocytes is also an important component; to this end, immune cell populations of interest are either labeled via the genetic attachment of fluorescent proteins or stained with antibodies or dyes. With the proper selection of methods at each step, twophoton intravital imaging can yield visual evidence regarding immune responses to inflammation.
Intravenous tPA (Tissue-Type Plasminogen Activator) in Patients With Acute Ischemic Stroke Taking Non–Vitamin K Antagonist Oral Anticoagulants Preceding Stroke (2018)

Background and Purpose- Although there are no trials or large cohorts to inform clinical care, current guidelines caution against giving intravenous tPA (tissue-type plasminogen activator) to patients with acute ischemic stroke who are taking non-vitamin K antagonist oral anticoagulants (NOACs). We performed a literature review of intravenous tPA in patients treated with NOACs preceding stroke. Methods- A literature search of PubMed was performed encompassing January 2010 to March 2018. Patient characteristics, timing of last medication intake, laboratory testing, use of reversal, and outcomes ≤3 months after discharge were summarized. Results- We identified 55 studies with 492 NOAC patients receiving tPA (dabigatran, 181; rivaroxaban, 215; apixaban, 40; and unspecified NOAC, 56). Among patients with complete data, the median time from the last NOAC intake to symptom onset was 8 hours (interquartile range, 2.5-14.5), with 55.2% (80/145) within 12 hours. Few patients underwent sensitive laboratory tests, such as thrombin time, diluted thrombin time, or anti-Xa assays before tPA administration. The overall observed rates of symptomatic intracranial hemorrhage, mortality, and favorable outcomes (National Institutes of Health Stroke Scale score, ≤1; modified Rankin Scale score, 0-2; or neurological improvement in the National Institutes of Health Stroke Scale score, ≥8 points) were 4.3% (20/462), 11.3% (48/423), and 43.7% (164/375), respectively. Among dabigatran-treated patients, reversal with idarucizumab was associated with fewer symptomatic intracranial hemorrhage (4.5% [2/44] versus 7.4% [8/108]; unadjusted odds ratio, 0.60; 95% CI, 0.12-2.92), death (4.5% [2/44] versus 12.0% [13/108]; unadjusted odds ratio, 0.35; 95% CI, 0.08-1.61), and more favorable outcomes (79.1% [34/43] versus 39.2% [29/74]; unadjusted odds ratio, 5.86; 95% CI, 2.45-14.00), although the differences were not statistically significant for symptomatic intracranial hemorrhage and death. Conclusions- These preliminary observations suggest that tPA may be reasonably well tolerated without prohibitive risks of bleeding complications in selected patients on NOACs. Reversal of anticoagulant effects by idarucizumab for dabigatran-treated patients before tPA is an emerging strategy that was associated with more favorable outcomes.
Char2Subword: Extending the Subword Embedding Space Using Robust\n Character Compositionality (2020)

Byte-pair encoding (BPE) is a ubiquitous algorithm in the subword\ntokenization process of language models as it provides multiple benefits.\nHowever, this process is solely based on pre-training data statistics, making\nit hard for the tokenizer to handle infrequent spellings. On the other hand,\nthough robust to misspellings, pure character-level models often lead to\nunreasonably long sequences and make it harder for the model to learn\nmeaningful words. To alleviate these challenges, we propose a character-based\nsubword module (char2subword) that learns the subword embedding table in\npre-trained models like BERT. Our char2subword module builds representations\nfrom characters out of the subword vocabulary, and it can be used as a drop-in\nreplacement of the subword embedding table. The module is robust to\ncharacter-level alterations such as misspellings, word inflection, casing, and\npunctuation. We integrate it further with BERT through pre-training while\nkeeping BERT transformer parameters fixed--and thus, providing a practical\nmethod. Finally, we show that incorporating our module to mBERT significantly\nimproves the performance on the social media linguistic code-switching\nevaluation (LinCE) benchmark.\n
"Prevention of Pelvic Inflammatory Disease by Screening for Cervical Chlamydial Infection". (1996)

Background Chlamydia trachomatis is a frequent cause of pelvic inflammatory disease. However, there is little information from clinical studies about whether screening women for cervical chlamydial infection can reduce the incidence of this serious illness. Methods We conducted a randomized, controlled trial to determine whether selective testing for cervical chlamydial infection prevented pelvic inflammatory disease. Women who were at high risk for disease were identified by means of a questionnaire mailed to all women enrollees in a health maintenance organization who were 18 to 34 years of age. Eligible respondents were randomly assigned to undergo testing for C. trachomatis or to receive usual care; both groups were followed for one year. Possible cases of pelvic inflammatory disease were identified through a variety of data bases and were confirmed by review of the women's medical records. We used an intention-to-screen analysis to compare the incidence of pelvic inflammatory disease in the two group...
Grass: its production and utilization. (1980)

Herbage production grasses and legumes the feeding value of grass and grass products grazing management the conservation of grass economic aspects of grass production and utilization grassland management for wildlife conservation and amenity application on the farm. Appendix: the common temperate grasses and legumes.
ICTP: An improved data collection protocol based OnCTP (2010)

Data collection is one of the basic tasks of WSN, and data collection protocol occupies a pivotal position in WSN. Data collection protocol in TinyOS 2.0 is implemented in the form of Collection Tree Protocol (CTP). However, CTP have proved to be extremely efficient, in practical applications, CTP also have some disadvantages. The paper presents an improved data collection protocol ICTP based on the analysis of CTP. The protocol introduces the concept of load balance into CTP. Finally, with the simulation results, we have proved that our improvement improves the efficiency and performance of the data collection task in WSN. There is something noteworthy that ICPT doesn't have additional energy as a result of not selecting the optimal path.
A Convergent Route to Novel Aliphatic Polyether Dendrimers (1998)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTA Convergent Route to Novel Aliphatic Polyether DendrimersManikandan Jayaraman and Jean M. J. FréchetView Author Information Department of Chemistry, University of California Berkeley, California 94720-1460 Cite this: J. Am. Chem. Soc. 1998, 120, 49, 12996–12997Publication Date (Web):December 1, 1998Publication History Received10 September 1998Published online1 December 1998Published inissue 1 December 1998https://pubs.acs.org/doi/10.1021/ja983229bhttps://doi.org/10.1021/ja983229brapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views1640Altmetric-Citations119LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Alcohols,Dendrons,Hydrocarbons,Mass spectrometry,Size exclusion chromatography Get e-Alerts
Stereochemistry of Deuterium Compounds of the Type RR'CXHXD: Ethyl-d4-ethylcarbinol (1937)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereochemistry of Deuterium Compounds of the Type RR'CXHXD: Ethyl-d4-ethylcarbinolFrank C. McGrew and Roger AdamsCite this: J. Am. Chem. Soc. 1937, 59, 8, 1497–1500Publication Date (Print):August 1, 1937Publication History Published online1 May 2002Published inissue 1 August 1937https://pubs.acs.org/doi/10.1021/ja01287a030https://doi.org/10.1021/ja01287a030research-articleACS PublicationsRequest reuse permissionsArticle Views38Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Structural Characterization of an Intermediate in Arene C−H Bond Activation and Measurement of the Barrier to C−H Oxidative Addition:  A Platinum(II) η2-Benzene Adduct [J. Am. Chem. Soc. 2001, 123, 12724−12725]. (2002)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionStructural Characterization of an Intermediate in Arene C−H Bond Activation and Measurement of the Barrier to C−H Oxidative Addition: A Platinum(II) η2-Benzene Adduct [J. Am. Chem. Soc.2001, 123, 12724−12725].Stefan Reinartz, Peter S. White, Maurice Brookhart, and Joseph L. TempletonCite this: J. Am. Chem. Soc. 2002, 124, 24, 7249Publication Date (Web):May 21, 2002Publication History Published online21 May 2002Published inissue 1 June 2002https://pubs.acs.org/doi/10.1021/ja0251017https://doi.org/10.1021/ja0251017correctionACS PublicationsCopyright © 2002 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views430Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (18 KB) Get e-Alertsclose Get e-Alerts
OCCUPATIONS AND SOCIALSTRUCTURE (2005)

Royalty and nobility 3,000 Baronets, knights and squires 50,000 Upper clergy, merchants and bankers, upper civil servants and lawyers 40,000 Independent gentry 150,000 Upper doctors and other professionals 20,000 Army and navy ofﬁcers 70,000 Lesser clergy 75,000 Upper freeholders 300,000 Ship owners, lesser merchants, shipbuilders, engineers and builders 200,000 Lesser professionals, civil servants and Dissenting ministers 250,000 Innkeepers 375,000 Shopkeepers and hawkers 600,000 Master craftsmen and manufacturers 450,000 Lesser freeholders 900,000 Farmers 1,300,000 Teachers, actors, clerks and shopmen 320,000 Artisans and other skilled workers 4,500,000 Agricultural labourers, miners, workers on road and canal, seamen 3,500,000 Personal and household servants 1,300,000 Sailors and soldiers 800,000 Paupers, vagrants, prisoners and lunatics 1,900,000Male Female Total population 10,224,000 10,736,000 Population of 10 years old and upwards 7,616,000 8,155,000 Agriculture: farmer, grazier, labourer, servant 1,563,000 227,000 Domestic service (excluding farm service) 134,000 905,000 Cotton worker, every kind, with printer, dyer 255,000 272,000 Building craftsman: carpenter, bricklayer, mason, 442,000 1,000plasterer, plumber, etc. Labourer (unspeciﬁed) 367,000 9,000 Milliner, dressmaker, seamstress (seamster) 494 340,000 Wool-worker, every kind, with carpet-weaver 171,000 113,000 Shoemaker 243,000 31,000 Coal-miner 216,000 3,000 Tailor 135,000 18,000 Washerwoman 145,000 Seaman (merchant), pilot 144,000 Silk worker 53,000 80,000 Blacksmith 112,000 592 Linen, ﬂax-worker 47,000 56,000 Carter, carman, coachman, postboy, cabman, 83,000 1,000busman, etc. Ironworker, founder, moulder 79,000 590 Railway driver, etc. porter, etc., labourer, 65,000 54platelayer Hosiery worker 35,000 30,000 Lace worker 10,000 54,000 Machine, boiler-maker 63,000 647 Baker 56,000 7,000 Copper, tin, lead-miner 53,000 7,000 Charwoman 55,000 Commercial clerk 44,000 19 Fisherman 37,000 1,000 Miller 37,000 562 Earthenware worker 25,000 11,000 Sawyer 35,000 23 Shipwright, boat-builder, block-and mast-maker 32,000 28 Straw-plait worker 4,000 28,000 Wheelwright 30,000 106 Glover 4,500 25,000 Nailer 19,000 10,000 Iron-miner 27,000 910
Positive Darwinian Selection at the Pantophysin (Pan I) Locus in Marine Gadid Fishes (2004)

Maximum-likelihood models of codon substitution were used to test for positive Darwinian selection at the vesicle protein pantophysin in two allelic lineages segregating in the Atlantic cod Gadus morhua and in 18 related species of marine gadid fishes. Positive selection was detected in the two intravesicular loops of the integral membrane protein but not in four membrane-spanning regions or the 3' cytoplasmic tail. The proportion of positively selected sites (24.9%) and the mean nonsynonymous/synonymous rate ratio (omega = d(N)/d(S) = 5.35) were both greater in the first intravesicular (IV1) domain compared with the second intravesicular (IV2) domain (11.0% positively selected sites with mean omega = 3.76). Likelihood ratio tests comparing models that assume identical omega ratios along all branches of the phylogeny to those that allow omega ratios to vary among lineages were not significant for either the IV1 or IV2 domains, indicating that the selective pressures favoring amino acid replacements have operated consistently in both regions during the diversification of the group. Positive selection was observed in the IV1 domain in both G. morhua allelic lineages, and, although three of the four codons that differ between alleles were targets of positive selection in the broader group, no similar polymorphisms were detected in other taxa. The two G. morhua Pan I alleles appeared to have evolved before the speciation event separating it from its sister taxon, Theragra chalcogramma, and on the basis of a standard mtDNA clock are estimated to be at least 2 Myr old. Although the function of pantophysin remains unknown, the strong signal of positive selection at specific sites in the IV1 and IV2 domains may help clarify its role in cellular trafficking pathways.
Unique effects on hepatic function, lipid metabolism, bone and growth endocrine parameters of estetrol in combined oral contraceptives (2015)

E4-containing combinations have a limited effect on liver function, lipid metabolism, and bone and growth endocrine parameters.
Investigation of Brassica juncea, Forsythia suspensa, and Inula britannica: phytochemical properties, antiviral effects, and safety (2019)

B. juncea may show antiviral effects against H1N1 in a host. In addition, B. juncea may also show decreased disadvantages compared to other antiviral agents.
Application of size exclusion chromatography with inductively coupled plasma emission spectrometric detection to residual oil hydrodesulfurization (HDS) and hydrodemetalization (HDM) studies (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTApplication of size exclusion chromatography with inductively coupled plasma emission spectrometric detection to residual oil hydrodesulfurization (HDS) and hydrodemetalization (HDM) studiesEdward L. Sughrue, Douglas W. Hausler, Ping C. Liao, and Daniel J. StropeCite this: Ind. Eng. Chem. Res. 1988, 27, 3, 397–401Publication Date (Print):March 1, 1988Publication History Published online1 May 2002Published inissue 1 March 1988https://pubs.acs.org/doi/10.1021/ie00075a006https://doi.org/10.1021/ie00075a006research-articleACS PublicationsRequest reuse permissionsArticle Views91Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Passive Immunization against HIV/AIDS by Antibody Gene Transfer (2014)

Despite tremendous efforts over the course of many years, the quest for an effective HIV vaccine by the classical method of active immunization remains largely elusive. However, two recent studies in mice and macaques have now demonstrated a new strategy designated as Vectored ImmunoProphylaxis (VIP), which involves passive immunization by viral vector-mediated delivery of genes encoding broadly neutralizing antibodies (bnAbs) for in vivo expression. Robust protection against virus infection was observed in preclinical settings when animals were given VIP to express monoclonal neutralizing antibodies. This unorthodox approach raises new promise for combating the ongoing global HIV pandemic. In this article, we survey the status of antibody gene transfer, review the revolutionary progress on isolation of extremely bnAbs, detail VIP experiments against HIV and its related virus conduced in humanized mice and macaque monkeys, and discuss the pros and cons of VIP and its opportunities and challenges towards clinical applications to control HIV/AIDS endemics.