gebhart/patrepeval huggingface dataset:
Preparation and reactions of diruthenium thiolate complexes [Cp*Ru(.mu.-SR)3RuCp*] (Cp* = .eta.5-pentamethylcyclopentadienyl; R = iso-Pr, Et, cyclohexyl, benzyl, Ph) (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and reactions of diruthenium thiolate complexes [Cp*Ru(.mu.-SR)3RuCp*] (Cp* = .eta.5-pentamethylcyclopentadienyl; R = iso-Pr, Et, cyclohexyl, benzyl, Ph)Somanath Dev, Yasushi Mizobe, and Masanobu HidaiCite this: Inorg. Chem. 1990, 29, 23, 4797–4801Publication Date (Print):November 1, 1990Publication History Published online1 May 2002Published inissue 1 November 1990https://pubs.acs.org/doi/10.1021/ic00348a039https://doi.org/10.1021/ic00348a039research-articleACS PublicationsRequest reuse permissionsArticle Views167Altmetric-Citations51LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Effects of steroidal and nonsteroidal antiinflammatory agents in neonatal endotoxemia. (1984)

The effects of steriodal and nonsteroidal antiinflammatory agents on mortality, plasma glucose and lactate levels, and pathologic alterations associated with Escherichia coli endotoxemia were assessed in neonatal rats. Animals were first injected subcutaneously with either high (LD95) or moderate (LD35) doses of endotoxin and immediately thereafter were administered either saline, dexamethasone, indomethacin, or glucose. Animals treated with saline or glucose developed significant hypoglycemia and hyperlactacidemia. Dexamethasone and indomethacin ameliorated the fall in glucose and the rise in lactate during high dose but not moderate dose endotoxemia. Pathologic changes consisting of widespread inflammation and hepatic necrosis were most marked in the saline- and indomethacin-treated animals. Only dexamethasone significantly reduced mortality at either LD95 or LD35 doses of endotoxin. We conclude that dexamethasone may reduce mortality in endotoxic shock through mechanisms other than simple amelioration of changes in plasma glucose.
Study on the Degrees of Freedom of Scattered Fields in Nonlinear Inverse Scattering Problems (2021)

In this work, we study the impact of contrast of scatterers on the degrees of freedom (DoF) of scattered fields in nonlinear inverse scattering problems (ISPs), and two numerical methods for calculating DoF are proposed. The number of DoF are proportional to the spatial bandwidth of the scattered field, which is affected by the electromagnetic properties of scatterers in the domain of investigation (DoI). Based on the discretized volume integral equations, an accurate numerical method for calculating the DoF is proposed by taking the maximum contrast of DoI into account. Furthermore, assuming that the contrast of DoI tends to infinity, the upper bound of DoF independent of contrast is obtained. Frequency-domain zero-padding method is applied to interpolate the field samples of the number of DoF into oversampled fields to calculate the approximation error. Numerical examples verify the accuracy of the proposed methods for calculating DoF.
Communication Modes with Large Intelligent Surfaces in the Near Field (2021)

This paper proposes a practical method for the definition of communication modes when antennas operate in the near-field region, by realizing ad-hoc beams exploiting the focusing capability of large antennas. The beamspace modeling proposed to define the communication modes is then exploited to derive expressions for their number (i.e., the degrees of freedom) in a generic setup, beyond the traditional paraxial scenario, together with closed-form definitions for the basis set at the transmitting and receiving antennas for several cases of interest, such as for the communication between a large antenna and a small antenna. Numerical results show that quasi-optimal communication can be obtained starting from focusing functions. This translates into the possibility of a significant enhancement of the channel capacity even in line-of-sight channel condition, without the need of implementing optimal but complex phase/amplitude profiles on transmitting/receiving antennas as well as resorting to intensive numerical solutions. Traditional results valid under paraxial approximation are revised in light of the proposed modeling, showing that similar conclusions can be obtained from different perspectives.
Crystallographic resolution and crystal and molecular structures of stereoisomers of 1,3,5-triglycidyl-s-triazinetrione (1989)

The crystal and molecular structures of alpha and beta isomers of the antineoplastic alkylating agent 1,3,5-triglycidyl-s-triazinetrione (TGT) have been determined by X-ray diffraction. Although the isomers differ chemically only in the order of a carbon and an oxygen atom in one of the glycidyl epoxide rings, the molecular conformations and crystal packing arrangements are very different. The different physical and biological properties of the two stereoisomers can be explained on the basis of the structures. The sample of alpha-TGT was found to be a mixture of alpha and beta forms, and it is suggested that use of pure alpha-TGT may lead to better therapeutic results.
Time Lapse VSP Program for Otway Basin CO2 Sequestration Pilot Project (2008)

The Australian Cooperative Research Centre for Greenhouse Gas Technologies (CO2CRC) is currently undertaking the Otway Basin Pilot Project, which involves the injection and storage of 100,000 tonnes of carbon dioxide within the subsurface. The Otway Project is the first of its kind, where CO2 injection will be into a depleted gas reservoir and, therefore, the project will provide important experience for monitoring and verification under these conditions. The overall complexity of the field, its depth, small size and the presence of free and residual gas zones present a serious challenge for 4D seismic monitoring. Accordingly, we adopted a monitoring strategy which combines surface and borehole seismic measurements that optimises our ability to verify CO2 containment. Design of the monitoring program involved numerical modelling and, crucially, pilot field tests. Of particular interest was the application of borehole seismic methods as they can provide better resolution, higher signal to noise ratio and superior repeatability in comparison to surface seismic data. Data recorded from several test VSP surveys and 3D base line VSP survey are analysed for quality, consistency and repeatability.
Pd-Catalyzed Ring-Opening/Arylation/Cyclization of 2-Aminothiazole Derivatives Provides Modular Access to Isocytosine Analogues (2022)

We report a Pd-catalyzed ring-opening/arylation/cyclization reaction sequence between 2-aminothiazoles and aryl (pseudo)halides that provides modular access to isocytosine analogues. The scope of the reaction is broad with respect to both coupling partners and a robustness test demonstrated the functional group tolerance of the methodology. Visual kinetic analysis revealed that the product may inhibit catalyst turnover for some substrates.
Increased myocardial native T1 relaxation time in patients with nonischemic dilated cardiomyopathy with complex ventricular arrhythmia (2017)

2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;47:779-786. In memoriam: The authors are grateful for Dr. Josephson's inspiring guidance and contributions to this study.
Experimental Comparison Of Computer Generated Holograms (1988)

Computer generated holograms (CGHs) are an important tool in the realization of optical processing systems. One of the reasons why CGHs are receiving attention is that there are high resolution recording devices available. High quality CGHs can be made and can now be utilized in optical data processing systems and algorithms. Many different CGH coding schemes exist, and much research is being done to compare and find their characteristics. This report presents a laboratory comparison of eight different types of CGHs. The method of making the CGHs and the recorder used are discussed. The experimental results are then compared with the non-experimental results derived previously.
Platinum Anticancer Coordination Compounds: Study of DNA Binding Inspires New Drug Design (2009)

Abstract A brief overview is given of platinum anticancer drugs in routine clinical use and under clinical development worldwide. Details of the binding of these drugs with nucleic acids, the preferred binding site, etc. are discussed as well. Using the mechanistic knowledge at the molecular level, in particular DNA binding, possibilities for new drugs are explored. A major part of the review deals with design, synthesis and biochemical/biophysical studies of such new compounds and their possible applications as cytostatic drugs. Special attention is given to the application of bifunctionality in such new compounds. (© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2009)
A bacterial gene, fip, required for filamentous bacteriophage fl assembly (1983)

An Escherichia coli mutant which does not support the growth of filamentous bacteriophage fl allows phage fl DNA synthesis and gene expression in mutant cells, but progeny particles are not assembled. The mutant cells have no other obvious phenotype. On the basis of experiments with phage containing nonlethal gene I mutations and with mutant fl selected for the ability to grow on mutant bacteria, we propose an interaction between the morphogenetic function encoded by gene I of the phage and the bacterial function altered in this mutant. The bacterial mutation defines a new gene, fip (for filamentous phage production), located near 84.2 min on the E coli chromosome.
Dynamic, High-Temperature, Flexible Seal (1989)

New seal consists of multiple plies of braided ceramic sleeves filled with small ceramic balls. Innermost braided sleeve supported by high-temperature-wire-mesh sleeve that provides both springback and preload capabilities. Ceramic balls reduce effect of relatively high porosity of braided ceramic sleeves by acting as labyrinth flow path for gases and thereby greatly increasing pressure gradient seal can sustain. Dynamic, high-temperature, flexible seal employed in hypersonic engines, two-dimensional convergent/divergent and vectorized-thrust exhaust nozzles, reentry vehicle airframes, rocket-motor casings, high-temperature furnaces, and any application requiring non-asbestos high-temperature gaskets.
PERFORMANCE ANALYSIS OF A PARALLEL BANYAN ATM SWITCH (1997)

Asynchronous transfer mode (ATM) switches can be constructed by connecting multiple banyan networks in parallel. To utilize the capacity of the parallel banyan networks fully, it is crucial to allow up to L cells from each input to be switched, and up to L cells to be received by each output simultaneously, where L is the total number of parallel banyan networks. This is possible if the switch operates in L overlapping phases and one banyan network is used to switch cells in each phase. Although a couple of such designs have been proposed and simulated, there is a lack of suitable models for such switches to be analysed mathematically. In this paper, two approximate analyses of a parallel banyan ATM switch are described. A comparison of the analytical and simulation results show that the analyses give reasonably accurate results. © 1997 by John Wiley & Sons, Ltd.
ChemInform Abstract: HETEROCYCLIC 8Π SYSTEMS, 8. 1,4‐DIHYDROPYRAZINES AND 1,4‐DIHYDROPYRAZINE ANIONS (1976)

Abstract Die Dihydropyrazine (I) sind zwar grundsätzlich zur Anionenbildung befähigt, bilden aber bei der Behandlung mit n‐Butyl‐Li keine Anionen, sondern lagem sich unter Deprotonierung der N‐Benzyl‐Gruppe in die Diazabicycloheptene (II) um.
Cost-effectiveness of a rapid and accurate test for diagnosing infection in severe sepsis and septic shock patients (2010)

Prompt and accurate pathogen identification is crucial for treatment of severe sepsis and septic shock (SS/SS). Blood cultures (BC) require 24 to 48 hours and often yield inaccurate results. Effective pathogen identification allows for timely, targeted antimicrobial therapy.
Evaluation of a Mathematical Model of Rat Body Weight Regulation in Application to Caloric Restriction and Drug Treatment Studies (2016)

The purpose of this work is to develop a mathematical model of energy balance and body weight regulation that can predict species-specific response to common pre-clinical interventions. To this end, we evaluate the ability of a previously published mathematical model of mouse metabolism to describe changes in body weight and body composition in rats in response to two short-term interventions. First, we adapt the model to describe body weight and composition changes in Sprague-Dawley rats by fitting to data previously collected from a 26-day caloric restriction study. The calibrated model is subsequently used to describe changes in rat body weight and composition in a 23-day cannabinoid receptor 1 antagonist (CB1Ra) study. While the model describes body weight data well, it fails to replicate body composition changes with CB1Ra treatment. Evaluation of a key model assumption about deposition of fat and fat-free masses shows a limitation of the model in short-term studies due to the constraint placed on the relative change in body composition components. We demonstrate that the model can be modified to overcome this limitation, and propose additional measurements to further test the proposed model predictions. These findings illustrate how mathematical models can be used to support drug discovery and development by identifying key knowledge gaps and aiding in the design of additional experiments to further our understanding of disease-relevant and species-specific physiology.
Updated international clinical recommendations on scar management: part 1--evaluating the evidence. (2014)

Advances in therapeutic options and new study data necessitate a revision of algorithms for the prevention and management of cutaneous scarring.
Evaluating the efficacy of benzoyl peroxide wash. (1996)

Clinical Pharmacology & Therapeutics (1996) 59, 167–167; doi: 10.1038/sj.clpt.1996.167
Compression of the Venusian ionosphere on May 10, 1979, by the interplanetary shock generated by the solar eruption of May 8, 1979 (1982)

An interplanetary shock wave that was produced by a solar eruption and its associated coronal transient on May 8, 1979, has been ‘tracked’ through interplanetary space to a rendezvous 2 days later with Venus. The interaction of the shock wave with the ionospheric obstacle at Venus produced a significant compression of the dayside ionosphere. It is believed that the tracking, as it were, was accomplished for the first time via the diagnostic observations provided by Hα and white light imagery near the sun and the plasma and field measurements of two, nearly radially aligned, spacecraft.
Optimization of electroplating, stencil printing, ball placement solder-bumping flip-chip process technologies (2004)

Three types of solder bumping processes are studied and optimized including electroplating, stencil printing and solder ball placement. In comparison with the sputtering UBM deposition process, the zincation process in the electroless NdAu process is very sensitive for the AI pad preparation process. The properties and effect of electroplated Cu stud and the electroless plated Ni stud are studied. Five kinds of photoresist materials are evaluated for the electroplating bumping process. In the solder bump placement process, the optimum laser power is controlled at the current range of 23 to 26mA with the exposure time of 8 to 10ms. According to the bumping sequences, the effect of every step on the quality and reliability of solder bumps are analyzed to improve the bumping process.
Über Inhaltsstoffe des Haschisch. 3., vorläufige Mitteilung. Umwandlung von (−)‐Δ6,1‐3,4‐trans‐Tetrahydrocannabinol in (−)‐Δ1,2‐3,4‐trans Tetrahydrocannabinol (1967)

Abstract Successive treatment of (−)‐Δ 6,1 ‐3,4‐ trans ‐tetrahydrocannabinol with hydrochloric acid/zinc chloride and potassium‐ t ‐amylate gives (−)‐Δ 1,2 ‐3,4‐ trans ‐tetrahydrocannabinol in quantitative yield.
Synthesis of Nitrogen-Containing Terminal Alkyl Chlorides via Copper-Catalyzed Chloromethylazidation (2021)

Key words copper catalysis - chloromethylation - azidation - radical relay
Multiple signal transduction mechanisms leading to the secretion of 5- hydroxytryptamine by MTC cells, a neurectodermally derived cell line (1990)

Parafollicular (PF) cells of the thyroid gland are neural crest derivatives. These cells remain plastic even in adult animals and can be induced to exhibit neural properties when exposed to NGF in vitro. A human cell line derived from PF cells, medullary thyroid carcinoma (MTC), has previously been shown to synthesize and store 5-HT, a serotonin-binding protein (SBP), and several neuropeptides; moreover, when grown in impoverished media, MTC cells display neural properties. The purpose of the current study was to utilize MTC cells as a neurally relevant model system to investigate factors involved in mediating 5-HT secretion. Electron microscopic immunocytochemistry revealed that secretory vesicles of MTC cells costore immunoreactive 5-HT with SBP and calcitonin. The cAMP derivative, N6-2'-O-dibutyryl-adenosine 3',5'-cyclic monophosphate (dibutyryl-cAMP; 1.0 mM) increased the concentration of 5-HT in MTC cells and almost doubled the rate of synthesis of 5-HT from L-tryptophan. Dibutyryl-cAMP also significantly increased the secretion of 5-HT. Cycloheximide (20 micrograms/ml) and anisomycin (20 microM) inhibited the dibutyryl-cAMP-induced increase of 5-HT release, suggesting that this action of dibutyryl-cAMP requires protein synthesis. Cholera toxin (1.0 microgram/ml) and forskolin (0.05 mM) in the presence of the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine (1.0 mM) both increased 5-HT biosynthesis and secretion. Attempts were made to identify a ligand that stimulates cAMP-mediated secretion of 5-HT. Both thyroid-stimulating hormone (TSH: 50 mU/ml) and elevated [Ca2+]e (7.0 mM), each of which acts as a secretogogue for PF cells, stimulated the secretion of 5-HT. The effect of TSH was Ca2(+)-dependent. Immunocytochemistry with monoclonal antibodies to the TSH receptor confirmed that these receptors are present on MTC cells. Neither TSH nor elevated [Ca2+]e elevated cAMP levels. Measurements of Fura-2 fluorescence, however, indicated that both TSH and elevated [Ca2+]e increased cytosolic calcium ([Ca2+]i), as did elevation of [K+]e. It is concluded that exocytosis can be triggered in MTC cells by multiple signal transduction mechanisms. Either cAMP or elevated [Ca2+]i can stimulate secretion; however, a secretogogue that increases cAMP has yet to be identified.
LMFBR fuel analysis. Task A: oxide fuel dynamics. Final report, July 1, 1975--September 30, 1976 (1976)

NRC for its review of the CRBRP are discussed with attention being drawn to heat transfer related issues.
Assessment of Ductile, Brittle, and Fatigue Fractures of Metals Using Optical Coherence Tomography (2018)

Some forensic in situ investigations, such as those needed in transportation (for aviation, maritime, road, or rail accidents) or for parts working under harsh conditions (e.g., pipes or turbines) would benefit from a method/technique that distinguishes ductile from brittle fractures of metals—as material defects are one of the potential causes of incidents. Nowadays, the gold standard in material studies is represented by scanning electron microscopy (SEM). However, SEM instruments are large, expensive, time-consuming, and lab-based; hence, in situ measurements are impossible. To tackle these issues, we propose as an alternative, lower-cost, sufficiently high-resolution technique, Optical Coherence Tomography (OCT) to perform fracture analysis by obtaining the topography of metallic surfaces. Several metals have been considered in this study: low soft carbon steels, lamellar graphite cast iron, an antifriction alloy, high-quality rolled steel, stainless steel, and ductile cast iron. An in-house developed Swept Source (SS) OCT system, Master-Slave (MS) enhanced is used, and height profiles of the samples’ surfaces were generated. Two configurations were used: one where the dimension of the voxel was 1000 μm3 and a second one of 160 μm3—with a 10 μm and a 4 μm transversal resolution, respectively. These height profiles allowed for concluding that the carbon steel samples were subject to ductile fracture, while the cast iron and antifriction alloy samples were subjected to brittle fracture. The validation of OCT images has been made with SEM images obtained with a 4 nm resolution. Although the OCT images are of a much lower resolution than the SEM ones, we demonstrate that they are sufficiently good to obtain clear images of the grains of the metallic materials and thus to distinguish between ductile and brittle fractures—especially with the higher resolution MS/SS-OCT system. The investigation is finally extended to the most useful case of fatigue fracture of metals, and we demonstrate that OCT is able to replace SEM for such investigations as well.
Unified logging system for monitoring multiple cloud storage providers in cloud storage broker (2018)

With the increasing demand for personal and enterprise data storage service, Cloud Storage Broker (CSB) provides cloud storage service using multiple Cloud Service Providers (CSPs) with guaranteed Quality of Service (QoS), such as data availability and security. However monitoring cloud storage usage in multiple CSPs has become a challenge for CSB due to lack of standardized logging format for cloud services that causes each CSP to implement its own format. In this paper we propose a unified logging system that can be used by CSB to monitor cloud storage usage across multiple CSPs. We gather cloud storage log files from three different CSPs and normalise these into our proposed log format that can be used for further analysis process. We show that our work enables a coherent view suitable for data navigation, monitoring, and analytics.
Single bacterial resolvases first exploit, then constrain intrinsic dynamics of the Holliday junction to direct recombination (2021)

Homologous recombination forms and resolves an entangled DNA Holliday Junction (HJ) crucial for achieving genetic reshuffling and genome repair. To maintain genomic integrity, specialized resolvase enzymes cleave the entangled DNA into two discrete DNA molecules. However, it is unclear how two similar stacking isomers are distinguished, and how a cognate sequence is found and recognized to achieve accurate recombination. We here use single-molecule fluorescence observation and cluster analysis to examine how prototypic bacterial resolvase RuvC singles out two of the four HJ strands and achieves sequence-specific cleavage. We find that RuvC first exploits, then constrains the dynamics of intrinsic HJ isomer exchange at a sampled branch position to direct cleavage toward the catalytically competent HJ conformation and sequence, thus controlling recombination output at minimal energetic cost. Our model of rapid DNA scanning followed by 'snap-locking' of a cognate sequence is strikingly consistent with the conformational proofreading of other DNA-modifying enzymes.