gebhart/patrepeval huggingface dataset:
The thermal chemistry of saturated layers of acetylene and ethylene on Ni(100) studied by in situ synchrotron x-ray photoelectron spectroscopy (2003)

Temperature-programmed x-ray photoelectron spectroscopy was used to study the thermal chemistry of acetylene (C2H2) and ethylene (C2H4) on Ni(100) in the temperature range 90–530 K. The use of a third generation synchrotron light source facilitated the measurement of high-resolution C 1s photoelectron spectra within a few seconds, approaching the ideal of real-time analysis. In a quantitative and quasi-continuous manner, the thermal dehydrogenation pathways are followed. For the acetylene decomposition, acetylide (CCH) and methylidyne (CH) are confirmed as intermediates. For the dehydrogenation of ethylene, a vinyl species (C2H3) is observed. Using the fingerprint capabilities of x-ray photoelectron spectroscopy, acetylene can be identified as the subsequent dehydrogenation product. Upon further heating, acetylide and methylidyne are successively formed on the surface, as in the decomposition experiment starting with acetylene adsorbed at 100 K. For both systems carbidic carbon is formed as the final dehydrogenation product, although with different transition temperatures. Species identification is based on observed vibrational fine structure data and correlation of core-level binding energies with previous literature.
Unstructured video-based rendering (2010)

We present an algorithm designed for navigating around a performance that was filmed as a "casual" multi-view video collection: real-world footage captured on hand held cameras by a few audience members. The objective is to easily navigate in 3D, generating a video-based rendering (VBR) of a performance filmed with widely separated cameras. Casually filmed events are especially challenging because they yield footage with complicated backgrounds and camera motion. Such challenging conditions preclude the use of most algorithms that depend on correlation-based stereo or 3D shape-from-silhouettes. Our algorithm builds on the concepts developed for the exploration of photo-collections of empty scenes. Interactive performer-specific view-interpolation is now possible through innovations in interactive rendering and offline-matting relating to i) modeling the foreground subject as video-sprites on billboards, ii) modeling the background geometry with adaptive view-dependent textures, and iii) view interpolation that follows a performer. The billboards are embedded in a simple but realistic reconstruction of the environment. The reconstructed environment provides very effective visual cues for spatial navigation as the user transitions between viewpoints. The prototype is tested on footage from several challenging events, and demonstrates the editorial utility of the whole system and the particular value of our new inter-billboard optimization.
[Artificial trabeculum (MESH). Clinical and histological study in the rabbit]. (1998)

The present study has shown that the filtering bleb appeared after 3 weeks without major hypotony. The material was integrated only in the intrascleral tunnel and was stable. After 6 months the Mesh was well tolerated. The new concept has a simple surgical technique, less invasive than trabeculectomy and required less surgical time. This technique reduced IOP and produced long survival blebs in rabbits. This device appears suitable for the surgical treatment of open angle glaucoma.
On Using Multiple Inverted Trees for Parallel Updating of Graph Properties. (1985)

Abstract : Fast parallel algorithms are presented for updating the distance matrix, shortest paths for all pairs and biconnected components for an undirected graph and the topological ordering of vertices of a directed acyclic graph when an incremental change has been made to the graph. The kinds of changes that are considered here include insertion of a vertex of insertion and deletion of an edge or a change in the weight of an edge. The machine model used is a parallel random access machine which allows simultaneous reads but prohibits simultaneous writes into the same memory location. The algorithms described in this paper require O(log n) time and use 0(N-cubed) processors. These algorithms are efficient when compared to previously known 0(log-squared of n) time start-over algorithms for initial computation of the above mentioned properties of graphs. The previous solution is maintained in mulple inverted trees (a rooted tree where a child node points toward its parent) and after a minor change the new solution is rapidly recomputed from these trees
First‐in‐human study of milvexian, an oral, direct, small molecule factor XIa inhibitor (2021)

Milvexian (BMS-986177/JNJ-70033093) is a small molecule, active-site inhibitor of factor XIa (FXIa) being developed to prevent and treat thrombotic events. The safety, tolerability, pharmacokinetics (PKs), and pharmacodynamics (PDs) of milvexian were assessed in a two-part, double-blind, placebo-controlled, sequential single ascending dose (SAD) and multiple ascending dose (MAD) study in healthy adults. Participants in SAD panels (6 panels of 8 participants; n = 48) were randomized (3:1) to receive milvexian (4, 20, 60, 200, 300, or 500 mg) or placebo. The 200- and 500-mg panels investigated the pharmacokinetic impact of a high-fat meal. Participants in MAD panels (7 panels of 8 participants; n = 56) were randomized (3:1) to receive milvexian (once- or twice-daily) or placebo for 14 days. All milvexian dosing regimens were safe and well-tolerated, with only mild treatment-emergent adverse events and no clinically significant bleeding events. In SAD panels, maximum milvexian plasma concentration occurred 3 h postdose in all fasted panels. The terminal half-life (T<sub>1/2</sub> ) ranged from 8.3 to 13.8 h. In fasted panels from 20 to 200 mg, absorption was dose-proportional; results at higher doses (300 and 500 mg) were consistent with saturable absorption. Food increased milvexian bioavailability in a dose-dependent fashion. In MAD panels, steady-state milvexian plasma concentration was reached within 3 and 6 dosing days with once- and twice-daily dosing, respectively. Renal excretion was less than 20% in all panels. Prolongation of activated partial thromboplastin time was observed and was directly related to drug exposure. These results suggest that the safety, tolerability, PK, and PD properties of milvexian are suitable for further clinical development.
A Spatial Game for Access Points Placement in Cognitive Radio Networks with Multi-Type Service (2010)

This paper studies the problem of determining locations of Secondary Access Points (SAPs) which belong to two competitive service providers in a certain region. SUs connect to the SAP according to their preferences. A key feature of our modeling approach is that it permits SAPs to set discriminatory powers for SUs, that is, SUs in different locations will be scheduled with different transmission powers. The profit maximizing SAPs compete with each other by setting locations and delivered power schedules to attract SUs, taking into account the impact of the revenue obtained and the power cost incurred. To study this competitive situation, an appropriate extensive form game is defined. The game can be viewed as two-staged. The selection of transmission powers by the SAPs can be investigated for each pair of locations. Then, the problem of location choice can be analyzed, anticipating what transmission powers will be chosen. We make an important observation: the Nash equilibrium of the game exists and the global revenue maximum strategy is a Nash equilibrium strategy. An example demonstrating how to place SAPs in a linear region is presented.
Density Functional Theory and Complete Basis Set Ab Initio Computational Study of Five-, Six-, Seven- and Eight-hydrogen Coordinated Carbon Cations (1999)

High level ab initio and density functional theory studies are performed on highly protonated methane species.
Coordination of Fresh Agricultural Product Supply Chain with Dual Channels Under Price and Fresh-Keeping Effort Dependent Demand (2018)

This electronic document is a “live” template and already defines the components of your paper [title, text, heads, etc.] in its style sheet. The pricing and fresh-keeping strategy is studied in the fresh agricultural product supply chain(FAPSC) composed of one supplier and one retailer. The retailer is in charge of selling the fresh agricultural products(FAP) through both online and offline channels. The supplier is in charge of producing FAP. The demand is affected by the retail price charged by the retailer and the fresh-keeping effort taken by the supplier. The optimal decisions of the centralized and decentralized FAPSC are analyzed and compared. The results show that the centralized FAPSC takes a higher fresh keeping effort and gains more profit. The revenue-sharing(RS) contract and revenue and fresh-keeping cost-sharing(RFCS) contract are proposed to coordinate the decentralized FAPSC. A numerical example are presented to illustrate the effectiveness of the contracts. The results show that both contracts can increase the profit of the decentralized FAPSC, while the RFCS contract can ensure that the decentralized FAPSC perform as the centrailzed one.
Novel single-poly EEPROM with damascene control-gate structure (2005)

A novel single-poly EEPROM using damascene control gate (CG) structure is presented in this letter. The CG is tungsten (W) line made by a damascene process, and intergate dielectric is Al/sub 2/O/sub 3/ grown by atomic layer deposition (ALD). The program and erase mechanism is the same as the one for traditional stacked-gate cell, which uses the channel hot electron injection for programming and Fowler-Nordheim tunneling for channel erasing. With the high dielectric constant (K) property of Al/sub 2/O/sub 3/, we can perform the program and erase function with a voltage less than 6.5 V, which can be handled by 3.3 V devices instead of traditional high voltage devices. In the process compatibility aspect, this new cell needs only two extra masking steps over the standard CMOS process, and the high-/spl kappa/ material is deposited in the back-end metallization steps without the contamination concerns on the front-end process. Therefore, this new technology is suitable for embedded application. In this letter, the good cell performance is demonstrated; such as, fast programming/erasing, good endurance and data retention.
A randomized controlled trial to investigate the impact of a low glycemic index (GI) diet on body mass index in obese adolescents (2014)

ClinicalTrials.gov Ref. No: NCT01278563.
Infection and immunoregulation of T lymphocytes by parainfluenza virus type 3. (1994)

Human parainfluenza virus type 3 (HPIV3) is a major cause of disease in newborns and infants. It also has a striking potential to reinfect individuals throughout their lives, suggesting that HPIV3 does not induce lifelong immunity; however, the operative mechanism for the failure to prevent reinfection is not known. We have assessed the potential of the virus to infect nontransformed human T lymphocytes and have found that T cells are readily infected by the virus. Productive infection requires activation of the T cells and results in a marked inhibition of proliferation. Furthermore, our results indicate that exposure to the virus, even without overt expression of viral proteins as detected by immunohistology, profoundly alters the functional capacity of the T cells. The capacity of the virus to regulate T-lymphocyte function may play an important role in the failure of the virus to induce lifelong immunity.
A crack model for nonlinear wave modulation spectroscopy (2001)

Nonlinear wave modulation spectroscopy is a novel technique for damage and crack evaluation based on the effect of modulation of ultrasonic waves by vibration. This technique was developed as an experimental approach and our goal is to discuss some mathematical models simulating these phenomena. The first model describes variation of resonance frequencies of the ultrasonic wave by breathing crack oscillation under low frequency vibration. This model considers an opened crack with the length changing under the action of vibration. The second model is concerned with plastic deformation in the vicinity of the crack tips that develops a hysteretic stress–strain relationship leading to the increase of ultrasonic wave damping. The Dugdale model is employed to describe ultrasonic wave damping and its variation under the vibration. These models relate modulation parameters to crack size and position. The suggested models explain the basic features of the observed modulation phenomena and could be used for characterization of the dimension and localization of cracks and crack-like damage.
Benefit of an extract of Tripterygium Wilfordii Hook F in patients with rheumatoid arthritis: A double‐blind, placebo‐controlled study (2002)

The ethanol/ethyl acetate extract of TWHF shows therapeutic benefit in patients with treatment-refractory RA. At therapeutic dosages, the TWHF extract was well tolerated by most patients in this study.
Fibronectin on target cells attenuates natural cytotoxicity of NK cells via myeloid immune checkpoint ILT3/LILRB4/gp49B (2023)

Natural killer (NK) cells play pivotal roles in innate immunity as well as in anti-tumor responses via natural killing, while their activity is tightly regulated by cell-surface inhibitory receptors. Immunoglobulin-like transcript 3/leukocyte immunoglobulin-like receptor B4 (ILT3/LILRB4, also known as gp49B in mice) is an inhibitory receptor expressed on activated NK cells as well as myeloid-lineage cells. The common physiologic ligand of human LILRB4 and gp49B was identified very recently as fibronectin, particularly the N-terminal 30 kDa domain (FN30). We hypothesized that LILRB4 could bind fibronectin on target cells in trans together with integrins, classical fibronectin receptors, in cis and deliver an inhibitory signal in NK cells, leading to attenuated natural killing. Flow cytometric and confocal microscopic analyses of NK cell-surface gp49B and integrins suggested that these novel and classical fibronectin receptors, respectively, co-engage fibronectin immobilized on a culture plate. Biochemical analyses indicated that tyrosine phosphorylation of spleen tyrosine kinase was augmented in gp49B-deficient NK cells upon binding to the immobilized fibronectin. While surface fibronectin-poor YAC-1 cells were evenly sensitive as to natural killing of both gp49B-positive and -negative NK cells, the killing of fibronectin-rich Lewis lung carcinoma cells, but not the FN30-knockout cells, was augmented among gp49B-deficient NK cells. These results suggest that the natural cytotoxicity of NK cells is negatively regulated through LILRB4/gp49B sensing fibronectin on target cells, which sheds light on the unexpected role of LILRB4 and fibronectin as a potential attenuator of NK cell cytotoxicity in the tumor microenvironment.
Role of reactive oxygen and nitrogen species in acute respiratory distress syndrome (2002)

Reactive oxygen species are reactive, partially reduced derivatives of molecular oxygen (O 2 ). Important reactive oxygen species in biologic systems include superoxide radical anion, hydrogen peroxide, and hydroxyl radical. Closely related species include the hypohalous acids, particularly hypochlorous acid; chloramine and substituted chloramines; and singlet oxygen. Reactive nitrogen species are derived from the simple diatomic gas, nitric oxide. Peroxynitrite and its protonated form, peroxynitrous acid, are the most significant reactive nitrogen species in biologic systems. A variety of enzymatic and nonenzymatic processes can generate reactive oxygen species and reactive nitrogen species in mammalian cells. An extensive body of experimental evidence from studies using animal models supports the view that reactive oxygen species and reactive nitrogen species are important in the pathogenesis of acute respiratory distress syndrome. This view is further supported by data from clinical studies that correlate biochemical evidence of reactive oxygen species-mediated or reactive nitrogen species-mediated stress with the development of acute respiratory distress syndrome. Despite these data, pharmacologic strategies directed at minimizing reactive oxygen species-mediated or reactive nitrogen species-mediated damage have yet to be successfully introduced into clinical practice. The most extensively studied compound in this regard is N -acetylcysteine; unfortunately, clinical trials with this compound in patients with acute respiratory distress syndrome have yielded disappointing results.
Identification of MST1/STK4 and SULF1 Proteins as Autoantibody Targets for the Diagnosis of Colorectal Cancer by Using Phage Microarrays (2011)

The characterization of the humoral response in cancer patients is becoming a practical alternative to improve early detection. We prepared phage microarrays containing colorectal cancer cDNA libraries to identify phage-expressed peptides recognized by tumor-specific autoantibodies from patient sera. From a total of 1536 printed phages, 128 gave statistically significant values to discriminate cancer patients from control samples. From this, 43 peptide sequences were unique following DNA sequencing. Six phages containing homologous sequences to STK4/MST1, SULF1, NHSL1, SREBF2, GRN, and GTF2I were selected to build up a predictor panel. A previous study with high-density protein microarrays had identified STK4/MST1 as a candidate biomarker. An independent collection of 153 serum samples (50 colorectal cancer sera and 103 reference samples, including healthy donors and sera from other related pathologies) was used as a validation set to study prediction capability. A combination of four phages and two recombinant proteins, corresponding to MST1 and SULF1, achieved an area under the curve of 0.86 to correctly discriminate cancer from healthy sera. Inclusion of sera from other different neoplasias did not change significantly this value. For early stages (A+B), the corrected area under the curve was 0.786. Moreover, we have demonstrated that MST1 and SULF1 proteins, homologous to phage-peptide sequences, can replace the original phages in the predictor panel, improving their diagnostic accuracy.
Phase II Study of Single-Agent Arsenic Trioxide for the Front-Line Therapy of Acute Promyelocytic Leukemia (2011)

The long-term follow-up of newly diagnosed patients with APL treated with single-agent arsenic trioxide shows high rates of DFS and OS.
Characterization and selection of vaginal Lactobacillus strains for the preparation of vaginal tablets (2002)

The dosage formulation developed in this study appears to be a good candidate for the probiotic prophylaxis and treatment of human vaginal infections.
Two mutations in the dispensable part of alanine tRNA synthetase which affect the catalytic activity. (1985)

Abstract Two previously described chromosomal mutant alleles, alaS4 and alaS5, of Escherichia coli Ala-tRNA synthetase have been analyzed. Each causes a sharp diminution in aminoacylation activity and disrupts the alpha 4 tetramer structure of identical chains of 875 amino acids; neither mutation significantly disturbs the activity for synthesis of alanyladenylate. The location of each mutation within the structural gene has been mapped by marker rescue with specific gene fragments. Each mutant allele was cloned from the genome by reciprocal recombination with a multicopy plasmid that contains segments of alaS which flank the respective mutations. Further analysis established: 1) a single G----A transition results in a Gly----Asp change for each mutant allele at codon 674 (alaS4) and at codon 677 (alaS5). 2) The mutations are in the oligomerization domain, about 200 amino acids beyond the C-terminal side of the catalytic domain that previously was mapped by deletion analysis; the mutations are, thus, in a part of the polypeptide which is dispensable for catalytic activity. 3) For both mutant enzymes, there is little effect of the mutation on the Km for tRNAAla; kcat for aminoacylation is decreased by an order of magnitude. These point mutations reveal a subtle integration of the catalytic core with parts of the polypeptide that are not essential for catalytic activity.
SAW-driven droplet jetting technology in microfluidic: A review (2020)

The introduction of surface acoustic wave (SAW) technology on microfluidics has shown its powerfully controlling and actuating fluid and particle capability in a micro-nano scale, such as fluid mixing, fluid translation, microfluidic pumping, microfluidic rotational motor, microfluidic atomization, particle or cell concentration, droplet or cell sorting, reorientation of nano-objects, focusing and separation of particles, and droplet jetting. The SAW-driven droplet jetting technology enjoys the advantages of simple structure to fabricate with little hindrance, compact size to integrate with other components, high biocompatibility with biological cells or other molecule samples, large force in realizing fast fluidic actuation, and contact-free manipulation with fluid. The realization of this technology can effectively overcome some bottleneck problems in the current micro-injection technology, such as mechanical swear, complicated and bulky structure, and strict limitation of requirements on fluidic characteristics. This article reviews and reorganizes SAW-microfluidic jetting technology from decades of years, referring to the interaction mechanism theory of SAW and fluid, experimental methods of SAW-microfluidic jetting, effects of related parameters on objected pinch-off droplets, and applications of individual structures. Finally, we made a summary of the research results of the current literature and look forward and appraise where this discipline of SAW-microfluidic jetting could go in the future.
Expression Signature of E2F1 and Its Associated Genes Predict Superficial to Invasive Progression of Bladder Tumors (2010)

We present a molecular signature that can predict, at diagnosis, the likelihood of bladder cancer progression and, possibly, lead to improvements in patient therapy.
A wearable spatial conferencing space (2002)

Wearable computers provide constant access to computing and communications resources. In this paper we describe how the computing power of wearables can be used to provide spatialized 3D graphics and audio cues to aid communication. The result is a wearable augmented reality communication space with audio enabled avatars of the remote collaborators surrounding the user. The user can use natural head motions to attend to the remote collaborators, can communicate freely while being aware of other side conversations and can move through the communication space. In this way the conferencing space can support dozens of simultaneous users. Informal user studies suggest that wearable communication spaces may offer several advantages, both through the increase in the amount of information it is possible to access and the naturalness of the interface.
Transmission electron microscopy characterization of the erbium silicide formation process using a Pt/Er stack on a silicon‐on‐insulator substrate (2006)

Very thin erbium silicide layers have been used as source and drain contacts to n-type Si in low Schottky barrier MOSFETs on silicon-on-insulator substrates. Erbium silicide is formed by a solid-state reaction between the metal and silicon during annealing. The influence of annealing temperature (450 degrees C, 525 degrees C and 600 degrees C) on the formation of an erbium silicide layer in the Pt/Er/Si/SiO(2)/Si structure was analysed by means of cross-sectional transmission electron microscopy. The Si grains/interlayer formed at the interface and the presence of Si grains within the Er-related layer constitute proof that Si reacts with Er in the presence of a Pt top layer in the temperature range 450-600 degrees C. The process of silicide formation in the Pt/Er/Si structure differs from that in the Er/Si structure. At 600 degrees C, the Pt top layer vanishes and a (Pt-Er)Si(x) system is formed.