gebhart/patrepeval huggingface dataset:
Double-Blind Study To Evaluate Flow Cytometry Analysis of Anti-Live Trypomastigote Antibodies for Monitoring Treatment Efficacy in Cases of Human Chagas' Disease (2002)

The validation of flow cytometry analysis of anti-live trypomastigote antibodies (FC-ALTA) to monitor cure after treatment of Chagas' disease was evaluated with serum samples from treated and nontreated chagasic patients. After optimization of the original technique, toward better sensitivity and applicability to field surveys, we design a double blind study of 94 coded samples classified into the following categories: patients not treated (NT) and patients treated but not cured (TNC), both presenting positive conventional serology and xenodiagnosis; patients treated and cured (TC), showing negative serology and xenodiagnosis; and patients treated under evaluation (TUE), who presented positive or oscillating conventional serology (CSA) but negative xenodiagnosis. Coded samples, diluted 1:256, were assayed by incubation with live cell culture trypomastigotes, which were subsequently stained with fluorescein isothiocyanate-conjugated anti-human immunoglobulin G, with prior fixation and analysis by flow cytometry. The results were expressed as the percentages of positive fluorescent parasites (PPFP) for each individual sample, establishing 20% PPFP as the cutoff between negative and positive results. Our data demonstrated that all NT and TNC presented positive results while all but one TC had a PPFP lower than 20%. Analysis of TUE demonstrated a wide degree of reactivity, with PPFP values that were negative (PPFP </= 20%), low positive (20% < PPFP </= 50%), and high positive (PPFP > 50%). As TUE with negative PPFP presented negative xenodiagnosis and positive or oscillating CSA, they were classified as dissociated according to the criteria of Krettli and Brener (J. Immunol. 128:2009-2012, 1982) and could indeed be considered cured after chemotherapy. This study demonstrates and validates the use of FC-ALTA to easily identify anti-live trypomastigote membrane-bound antibodies, offering another approach for investigating and monitoring the efficacy of specific chemotherapy in cases of human Chagas' disease.
Reduced Drying Time of Anodes for Lithium‐Ion Batteries through Simultaneous Multilayer Coating (2021)

The extended process chain starting from slurry mixing up to the operative lithium‐ion battery requires a deep understanding of each individual process step and knowledge of the interaction of the different process steps with each other. In particular, the intertwining of slurry mixing and drying determines the microstructure of the electrode, which in turn affects the performance of the cell. Herein, a scalable multilayer approach is used to tailor electrodes with improved mechanical and electrochemical properties, which disclose their advantages especially at high drying rates. Cryogenic broad ion beam scanning electron microscopy (Cryo‐BIB‐SEM) micrographs are used to reveal the influences of different process parameters, like slurry formulation, mixing device, and properties of the active material on the intrinsic network between active particles and binders in graphite‐based anode slurries. By a chosen combination of these slurries in a multilayer electrode, a tenfold acceleration of the drying time with favorable mechanical and electrochemical properties for full cells derived from these anodes is demonstrated.
Contemporary and future trends in cardiac resynchronization therapy to enhance response (2012)

The rationale for cardiac resynchronization therapy (CRT), expectations in terms of patient benefit, patient selection for CRT, selection of a CRT pacemaker (CRT-P) vs CRT plus implantable cardioverter-defibrillator (CRT-D) platform, and studies evaluating device programming to enhance benefit from CRT are reviewed. The notion of an "optimal" left ventricular (LV) pacing site, the rationale for identifying and avoiding LV pacing in regions of scar, the use of anatomic, hemodynamic, and electrical parameters to identify an optimal LV pacing site, and the potential utility of multisite LV pacing to enhance benefit from CRT are discussed. Finally, the advantages and disadvantages of the various methods for LV lead delivery are reviewed.
EXAMINATION OF THE DYNAMIC PROPERTIES OF 1 ST STAGE ROTOR BLADES IN ONE-PASS ENGINE COMPRESSORS UNDER OPERATING CONDITIONS (2013)

This article includes studies of vibration and stress amplitudes in the 1 st stage rotor blades of jet trainer one-pass engine compressors before and after refurbishment in operating conditions. The presented results were obtained using SAD-2 blade vibration amplitude registering and measuring apparatus. The same tests were carried on the same one-pass engine after modernisation. Example oscillograms from the vibration tests of the 16 blades are shown in this article, where show the vibrations of three randomly selected onepass engines after refurbishment (marked 1, 2 and 3) out of a total of 50 engines. The engine vibration spectra cover the full rotation speed range. The difference between the vibration amplitudes of 1st stage rotor blades, in one-pass engine compressors before and after the refurbishment, is results from the difference in how the blades were attached to the disc. Before modernisation the hammer-type root was used, whereas after refurbishment dovetail-type fittings were applied. Furthermore, it was confirmed that there is nocoupling via the blade disc occurred when the blades were arranged on the disc according to the sinusoidal order of their free vibration frequencies. In such cases recorded vibration amplitudes remain within the average range (from 100 to 120 MPa in terms of stress).
Mechanical behavior of a bi-stable negative-rate bias spring system (2010)

When a high electric field is applied across a dielectric electro-active polymer, the stiffness, in the in-plane direction, decreases. This change in stiffness can be used to generate linear actuation in the out-of-plane direction if the dielectric electro-active polymer (DEAP) is subject to a suitable bias force. This bias force is commonly provided by a linear spring, but a recent research work suggests the use of so-called negative-rate bias springs (NBS) to increase the achievable stroke. These systems are geometrically non-linear systems with bi-stable mechanical characteristics with a negative stiffness between equilibrium points that can be efficiently matched to the DEAP load/deformation behavior. This paper provides an overview of current work performed using NBS and discusses why NBS provide more displacement output. In addition, this paper presents a simple analytical model and a FE simulation of a negative-rate bias spring (NBS). The simple model is introduced to explain the non-linear snap-through behavior of the bi-stable NBS. FE simulated results obtained with bi-stable buckled beam are examined and compared with a linear spring model. The beam buckling and stiffness are identified to be analogous to the simple linear spring model's pre-compression and spring stiffness. These parameters can be used to tune a mechanism to appropriately match with a DEAP film. Future work includes NBS mechanism design and their coupling with circular DEAPs.
An upper bound on turbo code free distance (2002)

An upper bound on the free distance of turbo codes is developed by treating the codes as linear block codes and exploiting properties of the resulting generator matrix. The free distance upper bound is then used to lower bound the performance of turbo codes.
News Beyond Our Pages (2020)

In response to the novel COVID-19 global pandemic, there has been a mass mobilization of the scientific community to find a cure. Gao et al (Science, https://doi.org/10.1126/science.abc1932) have recently developed an inactivated SARS-CoV-2 virus candidate vaccine that induced production of neutralizing antibodies against multiple strains in rodents and non-human primates and protected macaque monkeys against infection without evidence of antibody-dependent immune enhancement. Parallel efforts are ongoing to repurpose existing drugs and develop novel therapeutic agents effective against COVID-19.
Risk-Averse Control via CVaR Barrier Functions: Application to Bipedal Robot Locomotion (2021)

Enforcing safety in the presence of stochastic uncertainty is a challenging problem. Traditionally, researchers have proposed safety in the statistical mean as a safety measure for systems subject to stochastic uncertainty. However, ensuring safety in the statistical mean is only reasonable if system's safe behavior in the large number of runs is of interest, which precludes the use of mean safety in practical scenarios. In this letter, we propose a risk sensitive notion of safety called conditional-value-at-risk (CVaR) safety. We introduce CVaR barrier functions as a tool to enforce CVaR-safety and propose conditions for their Boolean compositions. Given a legacy controller, we show that we can design a minimally interfering CVaR-safe controller via solving difference convex programs (DCPs). We elucidate the proposed method by applying it to a bipedal robot locomotion case study.
Mixed Reality. (1998)

「複合現実感」 (Mixed Reality) は, 現実世界と仮想世界を融合した複合環境の構築・描画技術で, これまでのVRの限界を打破する先端技術として期待されている.本稿では, 電子的な仮想世界を現実世界の情報で補強するAugmented Virtualityと, 現実世界に立脚しここに電子データを重畳するAugmented Realityに大別し, それぞれの最新技術動向を概観し, 今後の応用分野について展望する.
ChemInform Abstract: Intramolecular Reductive Coupling of Carbonyl‐Tethered Oxime Ethers Promoted by Samarium Diiodide: A Powerful Method for the Stereoselective Synthesis of Aminocyclopentitols. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Modeling Glucose Distribution in the Cornea (1990)

The central cornea obtains its glucose by diffusion through the cornea from the aqueous humor to the epithelium. The diffusion of glucose in the cornea is analogous to the flow of current in an electrical resistance network. The cellular consumption of glucose can be compared to shunting a portion of the charge to electrical ground. An electrical analog model of the cornea was developed to predict the availability of glucose to the epithelium and the distribution of glucose in the stroma. The glucose constant concentration lines in the normal stroma are parallel to the corneal surface and have decreasing values from 880 to 580 micrograms/ml. The effects on epithelial glucose concentration by implanting an intracorneal lens (ICL) of varying diameter, depth, permeability and thickness can be modeled. Glucose permeability through the intracorneal lens has the most significant effect on glucose availability. The ICL profile i.e. power, can also be an important fact in determining glucose availability. A minus power design requires a thin central lens zone with a thick peripheral zone. The design results in relatively more glucose flux through the optical zone of the lens and thus improves central epithelial glucose availability.
Electric-dipole spin resonance and spin orbit coupling effects in odd-integer quantum Hall edge channels (2023)

Structural-inversion-asymmetry effects on charge carriers can be described by a spin-orbit (Rashba) effective magnetic field. The direction of this field is fixed by the carrier momentum and axis of asymmetry - properties that form the basis of the spin transistor. The authors have used a sensitive terahertz magnetophotoresponse method to probe electrons in an asymmetric quantum well of InAs in the integer quantum-Hall-effect regime. Remarkable multiple-line spin-resonance spectra are attributed to oppositely directed Rashba fields of electrons in counterpropagating quasi-one-dimensional channels on opposite sample edges. Similar effects might lead to ultrafast electric-field control of spins for any spin-polarized topological edge channels.
Assumptions behind Intercoder Reliability Indices (2013)

(2013). Assumptions behind Intercoder Reliability Indices. Annals of the International Communication Association: Vol. 36, Communication Yearbook 36, pp. 419-480.
Isparta Yöresindeki Bazı Doğal Yerörtücü Bitkilerin Adaptasyonu ve Özellikleri (2014)

Günümüzde yerörtücü bitkiler, peyzaj amaçlı bitkisel tasarım çalışmalarında yaygın bir şekilde kullanılmaktadır. Yerörtücü bitkilerin başında, Poaceae familyasına ait çim türleri gelmektedir. Çim bitki türlerine nazaran daha fazla estetik ve işlevsel katkılar sağlayabilen, tesis ve bakım maliyeti daha az olabilen çok sayıda diğer otsu, yarı odunsu ve odunsu yerörtücü bitkiler bulunmaktadır. Isparta yöresi doğal zengin bitki potansiyeline sahip olmasına rağmen ne yazık ki yaygın bir şekilde kullanılmamakta veya bilinmemektedir. Bu nedenle özellikle yerörtücü bitkisi olabilecek doğal orjinli bitkilerin bireysel özelliklerinin tesbiti ve peyzaj amaçlı kullanılabilirliklerin araştırılması büyük önem taşımaktadır.&#13;\nBu çalışmada Isparta yöresinde yetişen bazı doğal yerörtücü bitkiler, arazi çalışmaları ile yerinden sökülmek suretiyle Süleyman Demirel Botanik Bahçesi içindeki deneme parsellerine dikildi. Toplam 15 farklı bitki türünden her biri için 27 şer adet bitki üzerinde işlemler gerçekleştirildi. Bu bitkiler üzerinde, tesisinden ilk iki yıldaki yaşama yüzdesi, bitki boyu, bitki kaplama değeri ve diğer bireysel özellikler tespit edildi. Bu türler içinde, Isparta yöresine iyi uyum sağlayabilecek ve değişik amaçlı peyzaj çalışmalarında kullanılabilecek ideal yerörtücü bitkileri “Thymus zygioides var zygioides, Pilosella hoppeana, Bolanthus minuartioides, Medicago lupulina, Ajuga chamaepitys subsp chia var. chia, Trifolium repens, Lotus corniculatus L. var. tenifolius, Helichryssum plicatum subsp plicatum, Festuca pinifolia, Primula veris L. subsp macrocalyx, Salvia tomentosa ve Vinca herbacea” şeklinde belirlendi.
Algorithm and Tool for Automated Ontology Merging and Alignment (2000)

Rapid eye movement (REM) sleep behavior disorder (RBD) may result in a patient injuring a bed partner while acting out a dream. This article examines the complexities associated with RBD as a criminal defense strategy as well as the legal implications for physicians and their duty to patients and their families to mitigate risks associated with possible injuries related to RBD.
Construção das representações irredutíveis das álgebras q deformadas Uq(su(2)) e Uq(sl(3)) na raiz da unidade. (1997)

\n As Álgebras Quânticas foram recentemente introduzidas como uma generalização das álgebras de Lie clássicas e estão sendo intensamente investigadas, tanto de um ponto de vista matemático quanto em aplicações envolvendo problemas de Mecânica Estatística e Física Molecular. As representações dessas álgebras podem ser construídas a partir de técnicas tradicionais e apresentam novidades se o parâmetro de deformação q for uma raiz complexa da unidade, e neste caso pode ocorrer perda de irredutibilidade e conseqüentemente alterações nas dimensões dessas representações. Primeiramente, estudamos as representações no caso clássico, a seguir introduzimos as deformações quânticas nas relações de comutação envolvendo os geradores associados as raízes simples. Posteriormente, estudamos especificamente o caso em que q é uma raiz complexa da unidade, à procura de novas reduções dimensionais que não aparecem no caso clássico. Mais precisamente, nos detemos ao estudo das representações das álgebras deformadas Uq(su(2)) e Uq(sl(3)), determinando suas a dimensões, os vetores de base do espaço portador e as suas matrizes irredutíveis. Por fim, calculamos o operador de Casimir quadrático deformado procurando saber como ficam as regras de ramificação da cadeia Uq(sl(3)) &amp;#8835 Uq(sl(2)).\n
HotSpotter? Neutron/Gamma Detector (2003)

The HotSpotter{trademark} Neutron/Gamma Detector combines in a single detecting module high sensitivity to gamma rays up to 3 MeV and sensitivity to neutrons. Using a 15 mm cubic CdWO{sub 4} (cadmium tungstate) crystal mounted on a 25 mm photomultiplier, the instrument realizes a factor of 5 increased photopeak efficiency over NaI(Tl) at 1 MeV, and a factor of 2 improvement over CsI(Tl). The addition of a 0.5 mm layer of {sup 10}B- impregnated epoxy covering the crystal provides neutron sensitivity without sacrificing gamma ray spectroscopic characteristics. Neutrons are detected by the presence of the 478 keV gamma from the {sup 10}B(n,{alpha}){sup 7}Li* reaction. In this paper, we describe the electronics and software of the instrument, and some of its characteristics.
Effects of Mn‐Doping on the Structural and Electrochemical Properties of Na3Ni2SbO6 for Sodium‐Ion Battery. (2019)

Abstract Recently, layered O′3‐Na 3 Ni 2 SbO 6 has been investigated as a unique cathode material for Na‐ion batteries due to the good electrochemical performance via O′3‐P′3 phase transitions in the voltage range between 2.0 and 4.0 V vs Na + /Na. However, at present it is not well understood whether transition metal doping of the pristine structure could improve the phase transition kinetics during charge/discharge. In this study, we synthesized Mn‐doped Na 3 Ni 2‐x Mn x SbO 6 ( x =0, 0.25, 0.5) layered oxides and investigated their feasibility as cathode materials for Na‐ion batteries using ex‐situ X‐ray diffraction (XRD) coupled with DFT calculations. The results show that light Mn doping ( x =0.25) energetically enhances the O′3‐P′3 phase transition kinetics with smaller unit‐cell‐volume changes. However, the heavily doped ( x =0.5) sample suffers from large polarization, which could be attributable to the reduced two‐phase reaction range and a large unit‐cell‐volume change upon sodium extraction.
Cerebral tissue oxygenation in reversible focal ischemia in rats: multi-site EPR oximetry measurements (2005)

Multi-site electron paramagnetic resonance (EPR) oximetry was used in vivo to measure the partial pressure of oxygen (pO2) in reversible focal ischemia in rats. The cerebral tissue pO2 was measured simultaneously and continuously at two sites on the ischemic side and one on the normal side of the brain in the same animal prior to and at several time points after ischemia and reperfusion. The O2 at the three different sites in brain was stable over 30 min of baseline measurements. During the first 120 min of ischemia, statistically significant decreases in brain pO2 from baseline were consistently observed in the ischemic core and perifocal area. The mean values varied during the 120 min of ischemia. Reperfusion resulted in an immediate increase in PO2, but there were no significant differences between the sites over time. The result of this study seems promising for the study of ischemia and reperfusion. It appears that the technique can provide information on the PO2 under the experimental conditions needed for such a study. The levels of PO2 that occurred in these experiments are readily resolvable by multi-site EPR oximetry. In addition, the ability simultaneously to measure the pO2 in several sites provides important additional information that should help to differentiate between changes in the PO2 due toglobal or local mechanisms.
Novel Schiff Base Copper Complexes of Quinoline-2 Carboxaldehyde as Proteasome Inhibitors in Human Prostate Cancer Cells (2006)

We report the synthesis of novel 1:1 Schiff base copper complexes of quinoline-2-carboxaldehyde showing dose-dependent, antiproliferative, and proapoptotic activity in PC-3 and LNCaP prostate cancer cells. We found that quinoline thiosemicarbazone 2 (FPA-137) was the most potent and inhibited proteosome activity in intact human prostate cancer PC-3 and LNCaP cells (IC50 of 4 and 3.2 microM, respectively) compared to clioquinol and pyrrolidine dithiocarbamate (IC50 of 10 and 20 microM), supporting the novelty of 2.
CD24, CD44 and EpCAM enrich for tumour-initiating cells in a newly established patient-derived xenograft of nasopharyngeal carcinoma (2017)

Subpopulations of nasopharyngeal carcinoma (NPC) contain cells with differential tumourigenic properties. Our study evaluates the tumourigenic potential of CD24, CD44, EpCAM and combination of EpCAM/CD44 cells in NPC. CD44br and EpCAMbr cells enriched for higher S-phase cell content, faster-growing tumourigenic cells leading to tumours with larger volume and higher mitotic figures. Although CD44br and EpCAMbr cells significantly enriched for tumour-initiating cells (TICs), all cells could retain self-renewal property for at least four generations. Compared to CD44 marker alone, EpCAM/CD44dbr marker did not enhance for cells with faster-growing ability or higher TIC frequency. Cells expressing high CD44 or EpCAM had lower KLF4 and p21 in NPC subpopulations. KLF4-overexpressed EpCAMbr cells had slower growth while Kenpaullone inhibition of KLF4 transcription increased in vitro cell proliferation. Compared to non-NPC, NPC specimens had increased expression of EPCAM, of which tumours from advanced stage of NPC had higher expression. Together, our study provides evidence that EpCAM is a potentially important marker in NPC.
Appendix A: Transmission Line Theory (2000)

This appendix presents an outline of microwave transmission line theory including the elements of impedance matching using transmission lines and also coupled transmission line theory that is used in Chapter 8. The background for the developments here is the TEM-Mode transmission line theory presented in Section 1.6 on page 14. Recall that a TEM-mode transmission line has its electric and magnetic field lines in the plane transverse to the direction of the line (direction of propagation). Thus TEM-mode stands for Transverse Electro-Magnetic mode. The coaxial line is the most common such line. Other lines, such as microstrip, have field distributions that are only approximately transverse,-and these are called quasi-TEM. Nevertheless, their characterization is referenced to a TEM-mode line.
Smart Homecare System for Health Tele-monitoring (2007)

An increasing aged population worldwide puts our medical capabilities to the test. Research and commercial groups are investigating novel ways to care for the aged and chronically ill both in their own homes and in care facilities. This paper describes a prototype we have developed for remote healthcare monitoring. This personalized smart homecare system uses smart phones, wireless sensors, Web servers and IP Webcams. To illustrate the functionality of the prototype we describe a series of typical tele-health monitoring scenarios.
Expression of zinc finger E-box-binding homeobox factor 1 in epithelial ovarian cancer: A clinicopathological analysis of 238 patients (2015)

A growing body of evidence indicates that aberrant activation of epithelial-to-mesenchymal transition (EMT) plays a key role in tumor cell invasion and metastasis. Zinc finger E-box-binding homeobox factor 1 (ZEB1), as a crucial mediator of EMT, contributes to the malignant progression of various epithelial tumors. To determine whether ZEB1 is involved in the progression of ovarian cancer, we immunohistochemically evaluated the expression of ZEB1 in 238 cases of epithelial ovarian cancer (EOC) and analyzed its associations with clinicopathological parameters. Positive expression of ZEB1 was observed in 32.8% (78/238) of EOCs and it was found to be significantly associated with advanced tumor stage (P=0.001). The survival analysis indicated that the expression of ZEB1 was associated with a poor 5-year progression-free survival (PFS) (P=0.021). A similar tendency was also observed between the expression of ZEB1 and 5-year overall survival, although it did not reach statistical significance (P=0.118). Moreover, the multivariate analysis demonstrated that ZEB1 expression was an independent risk factor for 5-year PFS in ovarian cancer. Taken together, our data provide evidence that ZEB1 may play a crucial role in promoting aggressive ovarian carcinoma progression. Therefore, ZEB1 may serve as an effectively predictive marker and a potential target for therapeutic intervention in EOC.