gebhart/patrepeval huggingface dataset:
Hypotensive Resuscitation during Active Hemorrhage: Impact on In-Hospital Mortality (2002)

Titration of initial fluid therapy to a lower than normal SBP during active hemorrhage did not affect mortality in this study. Reasons for the decreased overall mortality and the lack of differentiation between groups likely include improvements in diagnostic and therapeutic technology, the heterogeneous nature of human traumatic injuries, and the imprecision of SBP as a marker for tissue oxygen delivery.
Erratum: Catala, A., et al. Is There a Profile of Spontaneous Seizure-Alert Pet Dogs? A Survey of French People with Epilepsy. Animals 2020, 10, 254 (2021)

The authors wish to make the following corrections to this paper: [...].
Walk on Floor Eyes Closed Test: A Unique Test of Spaceflight Induced Ataxia (2011)

Measurement and quantification of posture and locomotion following spaceflight is an evolving process. Based on the data obtained from the current investigation we believe that the walk on the floor line test with the eyes closed (WOFEC) provides a unique procedure for quantifying postflight ataxia. As a part of an ongoing investigation designed to look at functional changes in astronauts returning from spaceflight seven astronauts (5 short duration with flights of 12-16 days; 2 long duration crewmembers with flights of 6 months) were tested twice before flight, on landing day (short duration only), and 1, 6, and 30 days after flight. The WOFEC consisted of walking for 10 steps (repeated twice) with the feet heel to toe in tandem, arms folded across the chest and the eyes closed. The performance metric (scored by three examiners from video) was the percentage of correct steps completed over the three trials. A step was not counted as correct if the crewmember side-stepped, opened their eyes, or paused for more than three seconds between steps. The data reveled a significant decrease in percentage of correct steps on landing day (short duration crew) and on the first day following landing (long duration) with partial recovery the following day, and full recovery beginning on day sixth after flight. Both short and long duration fliers appeared to be unaware of foot position relative to their bodies or the floor. Postflight, deviation from a straight path was common, and seemed to be determined by the angle of foot placement relative to their body. While deviation from a straight line could be either left or right, primary deviations were observed to occur to the right. Furthermore, the test for two crewmembers elicited motion sickness symptoms. These data clearly demonstrate the sensorimotor challenges facing crewmembers after returning from spaceflight. The WOFEC test has value providing the investigator or crew surgeon with a simple method to quantify vestibular ataxia, as well as providing instant feedback of postural ataxia without the use of complex test equipment.
A Feminist Reflection on the Declarations of Paris and Dili: Towards Re-Imagining the Aid and Development Endeavour (2013)

Reflectively reading international declarations on aid effectiveness and development brings to light the metaphors of the aid relationship and of development embedded in these texts. The paradigm that shapes the Paris Declaration on Aid Effectiveness (2005) defines development as an outcome of a particular set of relationships between donors and partner countries. It reflects a world view in terms of countable objects and predictable outcomes. The Dili Declaration (2010), by contrast, re-imagines development as a visionary endeavour, encompassing inclusive relationships and processes, responsive to context, and permeated with power.
Role of Protein Synthesis, Prostaglandins, and Estrogen in Rat Ovarian Metalloproteinase Inhibitor Production (1993)

Matrix metalloproteinases and their inhibitors regulate follicular connective tissue remodeling associated with ovulation. We examined the control of metalloproteinase inhibitor activity and gene expression by various treatments in cultured rat granulosa cells and intact whole ovaries. Cells were isolated from preovulatory follicles of immature eCG-primed rats and cultured with various treatments for 24 h. Metalloproteinase inhibitor activity was measured in the media. The addition of LH or the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) increased inhibitor activity 2.5- and 2.6-fold above that in control cultures, respectively. Cycloheximide treatment blocked basal and LH- and TPA-stimulated inhibitor activity, suggesting that the increase in granulosa cell inhibitor activity resulted from de novo protein synthesis. Indomethacin, a prostaglandin synthase inhibitor, had no effect on basal or LH-induced granulosa cell inhibitor activity. Addition of the antiestrogen tamoxifen citrate or an aromatase inhibitor, 10-propargylestr-4-ene-3,17-dione, did not affect basal or LH-stimulated inhibitor activity, implying that estrogen is not involved in the signal transduction pathway leading to increased inhibitor activity. Northern analysis demonstrated the presence of mRNA for a tissue-derived metalloproteinase inhibitor, TIMP-1, which increased with LH stimulation, in rat granulosa cells. Similarly, an hCG stimulus increased TIMP-1 mRNA in periovulatory ovaries to the highest levels prior to ovulation. Neither cycloheximide nor indomethacin altered hCG-stimulated TIMP mRNA levels in periovulatory ovaries. The present study demonstrates that the LH- and TPA-induced increase in inhibitor activity resulted from de novo protein synthesis; however, de novo protein synthesis does not appear necessary for the increase in TIMP mRNA.(ABSTRACT TRUNCATED AT 250 WORDS)
Machine Learning Assisted Real-Time Label-Free SERS Diagnoses of Malignant Pleural Effusion due to Lung Cancer (2022)

More than half of all pleural effusions are due to malignancy of which lung cancer is the main cause. Pleural effusions can complicate the course of pneumonia, pulmonary tuberculosis, or underlying systemic disease. We explore the application of label-free surface-enhanced Raman spectroscopy (SERS) as a point of care (POC) diagnostic tool to identify if pleural effusions are due to lung cancer or to other causes (controls). Lung cancer samples showed specific SERS spectral signatures such as the position and intensity of the Raman band in different wave number region using a novel silver coated silicon nanopillar (SCSNP) as a SERS substrate. We report a classification accuracy of 85% along with a sensitivity and specificity of 87% and 83%, respectively, for the detection of lung cancer over control pleural fluid samples with a receiver operating characteristics (ROC) area under curve value of 0.93 using a PLS-DA binary classifier to distinguish between lung cancer over control subjects. We have also evaluated discriminative wavenumber bands responsible for the distinction between the two classes with the help of a variable importance in projection (VIP) score. We found that our label-free SERS platform was able to distinguish lung cancer from pleural effusions due to other causes (controls) with higher diagnostic accuracy.
Cyclical Mastalgia: Prevalence and Impact in an Outpatient Breast Clinic Sample (1997)

Reported prevalences of mastalgia obtained in this sample are higher than those reported in British studies; possible reasons for these differences are discussed. Cyclical mastalgia is a common problem sometimes severe enough to interfere with normal activity levels, and it is related to excessive use of mammography among young women. Although largely ignored both scientifically and clinically in the United States, this condition merits further biopsychosocial investigation.
471. In Vivo Potency Assay for AAV-Based Gene Therapy Vectors (2016)

One hurdle in the translation of adeno-associated virus (AAV) vectors for the treatment of human disease is the challenge in demonstrating drug function in a potency assay, a requirement in the clinical translation to product. In vitro measurements of AAV potency suffer from poor efficiency of infectivity and are insensitive measures of potency. To address this issue, we have developed a robust in vivo assay for the measurement of vector potency. Using as the model vector the AAVrh.10 serotype coding for human frataxin (FXN, a mitochondrial protein essential for cellular function and that is deficient in Friedreich's ataxia), and based on the knowledge that intravenous administration of all AAV vectors primarily transduce the liver, we have developed a reproducible in vivo potency assay that can be used to set quality control standards for vector production. The assay is based on administration of the AAV vector (2.5 × 1010 genome copies) administered intravenously to 6 to 8 wk old Balb/c male mice with the liver harvested 2 wk later following PBS perfusion. Liver homogenates are processed to assess vector genome copies, transgene mRNA, and expressed protein. In order to establish acceptance criteria for assays of vector genome and mRNA levels, separate specifications were set for DNA sample load using the mouse housekeeping gene Tfrc, and RNA sample load using mouse 18S RNA, both based on data from quantitative PCR analysis of mouse livers (n=35) assayed in duplicate. Specifications were set as the median ± 2 standard deviations based on these assay results; for the potency assay results to be accepted, each of these specifications must be met by the test sample. For the AAVrh. 10 vector expressing FXN(AAVrh.10hFXN), liver vector genome levels (a measure of reproducibility of delivery) were 8.2 × 104 ± 2.2 × 104 genome copies/µg genomic DNA (n=10 mice, mean ± SD), liver human FXN mRNA levels (a measure of vector potency at the transcription level) were 2.2 × 103 ± 0.7 × 103 copies/µg total RNA (n=10 mice, mean ± SD) and liver human FXN protein levels (ELISA; a measure of vector potency at the protein level) were 54.8 ± 17.52 ng/mg protein (n=10 mice, mean ± SD). From this data, we established the following quality control specifications for AAVrh.10hFXN vectors: vector genome range 6 × 104 - 1 × 105 (copies/µg DNA), hFXN mRNA level range 1.6 × 103 - 2.9 × 103 (copies/µg RNA) and the hFXN protein levels 37 - 72 (ng/mg protein). This approach is adaptable to any AAV vector, providing an in vivo quality control for vector function.
X-ray optics of in-situ synchrotron topography studies of the early stages of relaxation in epitaxial InGaAs on GaAs (1998)

High resolution X-ray topography and diffraction measurements have been made at the Daresbury Synchrotron Radiation Source during in-situ molecular beam epitaxial growth of InGaAs on GaAs. Critical analysis of dislocation contrast, intensity and geometrical distortion reveals that use of the 224 reflection in the Bragg geometry at 1.48 Angstrom wavelength is optimal for such double crystal topography experiments. Examination of the beam-conditioner characteristics and performance had resulted in use of the 333 reflection from a channel-cut silicon crystal as a monochromator. We deduce and show experimentally that a 004 channel-cut monochromator is optimal, resulting in significant reduction in exposure times. We present images of misfit dislocations showing evidence for the first time of phase contrast from lattice distortions.
Genetic Characteristics of Cellulose-Forming Acetic Acid Bacteria Identified Phenotypically asGluconacetobacter xylinus (2000)

Gluconacetobacter xylinus (=Acetobacter xylinum) shows variety in acid formation from sugars and sugar-alcohols. Toyosaki et al. proposed new subspecies of G. xylinus (=Acetobacter xylinum) subsp. sucrofermentans in point of acid formation from sucrose and a homology index of 58.2% with the type strain of G. xylinus subsp. xylinus in DNA-DNA hybridization experiments. We tried DNA-DNA hybridization to clarify relationship between acid formation from sugars and classification of G. xylinus. The G + C contents of G. xylinus showed 60.1-62.4 mol% with a range of 2.3 mol%. When type strains of G. xylinus subsp. xylinus, G. xylinus subsp. sucrofermentans, and IFO 3288 forming acid from sucrose, were used as probes, the DNAs from three strains showed 67-100%, 64-89%, and 60-100% similarity to those from sixteen strains including bacteria that form acid from sucrose or not. These results show that homology indexes do not reflect differences of acid formation from sucrose. As a results, the species G. xylinus was proved to be genetically homogeneous.
A method for estimating sound speed and the void fraction of bubbles from sub-bottom sonar images of gassy seabeds (2007)

There is increasing interest in the effect of bubbles in gassy sediment. This is, first, because of&lt;br/&gt;the impact those bubbles have on the structural integrity and load-bearing capabilities of the&lt;br/&gt;sediment; second, because the presence of bubbles can be indicative of a range of biological,&lt;br/&gt;chemical or geophysical processes (such as the climatologically-important flux of methane&lt;br/&gt;from the seabed to the atmosphere); and third, because of the effect which the bubbles have&lt;br/&gt;on any acoustic systems used to characterise the sediment. For this reason, a range of methods&lt;br/&gt;have been investigated for their ability to estimate the bubble population in the seabed. Within&lt;br/&gt;such a range, there will a mix of advantages and limitation to given techniques. This report&lt;br/&gt;outlines a very basic method by which an observations which have already been taken for&lt;br/&gt;other purposes (sub-bottom profiles) may be subjected to a rapid analysis to obtain an&lt;br/&gt;estimate of the effect of bubbles on the sound speed in the sediment, and from there to&lt;br/&gt;provide a rapid preliminary estimate of the void fraction of bubbles present (assuming quasistatic&lt;br/&gt;bubble dynamics). This approach is not meant to compete with large-scale field trials&lt;br/&gt;which deploy specialist equipment to monitor gas bubbles in sediment, but rather to provide a&lt;br/&gt;method to exploit archived sub-bottom profiles, or to survey a large area rapidly with&lt;br/&gt;commercial equipment from a small vessel, in order to obtain an estimation of the local void&lt;br/&gt;fractions present, and their location and extent in three dimensions.
Use of second-order switching surface in the boundary control of buck converter (2004)

A second-order switching surface in the boundary control of buck converters is studied in this paper. The formulated switching surface can make the overall converter exhibit better steady-state and transient behaviors than the one with first-order switching surface. Most importantly, it is applicable for converters operating in both continuous and discontinuous conduction modes. The switching surface is derived from estimating the state trajectory movement after a switching action, resulting in a high state trajectory velocity along the switching surface. This phenomenon accelerates the trajectory moving towards the target operating point. The proposed control scheme has been successfully applied to a 120 W buck converter. Detailed large-signal characteristics and comparisons with the first-order switching surface is discussed.
Contact heat sensitivity and reports of unpleasantness in communicative people with mild to moderate cognitive impairment in Alzheimer’s disease: a cross-sectional study (2016)

The between-group findings demonstrate that when compared to controls, people with AD are less sensitive to the detection of thermal pain but do not differ in affective response to the unpleasant aspects of thermal pain. These findings suggest that people with AD may experience greater levels of pain and potentially greater levels of tissue or organ damage prior to identifying and reporting injury. This finding may help to explain the decreased frequency of pain reports and consequently a lower administration of analgesics in AD.
LXXII. On the action of metallic copper on solutions of certain metals, particularly with reference to the detection of arsenic (1841)

(1841). LXXII. On the action of metallic copper on solutions of certain metals, particularly with reference to the detection of arsenic. The London, Edinburgh, and Dublin Philosophical Magazine and Journal of Science: Vol. 19, No. 126, pp. 480-483.
Characterization of bacterial-type phosphoenolpyruvate carboxylase expressed in male gametophyte of higher plants (2010)

Our results suggest that an LlBTPC:Ub-LlPTPC:LlPTPC complex is formed in the VC cytoplasm during late pollen development. Both LlBTPC and AtBTPC expression patterns are similar to the patterns of the appearance of storage organelles during pollen development in lily and Arabidopsis, respectively. Therefore, BTPC is thought to accelerate the metabolic flow for the synthesis of storage substances during pollen maturation. Our study provides the first characterization of BTPC in pollen, the male gametophyte of higher plants.
African swine fever in North Sumatra and West Java provinces in 2019 and 2020, Indonesia (2021)

African swine fever (ASF) is a highly lethal and contagious viral haemorrhagic disease of domestic and wild pigs, caused by the ASF virus (ASFV). After entering China in 2018, the disease has continued to spread through Asia. In September 2019, a team from the Indonesian Research Center for Veterinary Science, Bogor, investigated outbreaks in backyard pigs in the Dairi and Humbang Hasundutan districts of North Sumatra province. In January 2020, three pigs purchased from a pig seller in Bogor District, West Java province were also tested. Real-time PCR results confirmed ASFV DNA in sixteen out of twenty-nine samples, with nine positive samples from North Sumatra and seven from West Java. Four partial or full-length genes (i.e. p72, p54, pB602L and CD2v) and a 356-bp fragment between the I73R and I329L genes were sequenced from representative samples. Phylogenetic analysis established that the ASFV in the samples from both North Sumatra and West Java were identical, indicating a common source of infection, and that they belonged to the p72 genotype II and serogroup 8. The sequences from the Indonesian ASFVs were also identical to other genotype II ASFV from domestic pigs in Vietnam, China and Russia.
PHYSICS EDUCATION - HOW NEW TECHNOLOGIES CAN ATTRACT IT? (2018)

Z. Palkova1K. Kovas2M. Harničárová3F. Grivokostopoulou2J. Valíček3I. Perikos4M. Kušnerová3V. Galanis2M. Repka3I. Hatzilygeroudis2
Reduced Dimensional Representations of Molecular Structure (1997)

Two-dimensional representations of molecular structure may be generated from the three-dimensional coordinates by nonlinear mapping. These representations not only retain the look of familiar structural formulas but also incorporate the distance geometry information available in three-dimensional structures. The technique is shown to be trivial so long as the molecular structure is not essentially spherical and an objective test as to whether this is true is introduced, together with extensions for coping with such cases. The two-dimensional diagrams have great promise in handling molecular similarity and data searching with very large numbers of compounds since they permit the use of two-dimensional pattern recognition techniques.
Using virtual markets to program global behavior in sensor networks (2004)

This paper presents market-based macroprogramming (MBM), a new paradigm for achieving globally efficient behavior in sensor networks. Rather than programming the individual, low-level behaviors of sensor nodes, MBM defines a virtual market where nodes sell "actions" (such as taking a sensor reading or aggregating data) in response to global price information. Nodes take actions to maximize their own utility, subject to energy budget constraints. The behavior of the network is determined by adjusting the price vectors for each action, rather than by directly specifying local node actions, resulting in a globally efficient allocation of network resources. We present the market-based macro-programming paradigm, as well as several experiments demonstrating its value for a sensor network vehicle tracking application.
Portfolio Concentration and Firm Performance (2014)

Abstract This paper investigates the relation between shareholders’ portfolio concentration and firm performance. Using data on more than 1.3 million unique shareholders, we create an index that measures how concentrated shareholder portfolios are in each firm. We posit that portfolio concentration will affect incentives when shareholders are resource constrained. We find that average shareholder portfolio concentration is positively related to future operational performance and valuation. We also find that portfolio concentration is positively correlated with abnormal stock returns. Our findings suggest that shareholders with concentrated portfolios are more informed and play a governance role through the stock market.
The rippled β-sheet layer configuration—a novel supramolecular architecture based on predictions by Pauling and Corey (2022)

The rippled β-sheet is a peptidic structural motif related to but distinct from the pleated β-sheet. Both motifs were predicted in the 1950s by Pauling and Corey. The pleated β-sheet was since observed in countless proteins and peptides and is considered common textbook knowledge. Conversely, the rippled β-sheet only gained a meaningful experimental foundation in the past decade, and the first crystal structural study of rippled β-sheets was published as recently as this year. Noteworthy, the crystallized assembly stopped at the rippled β-dimer stage. It did not form the extended, periodic rippled β-sheet layer topography hypothesized by Pauling and Corey, thus calling the validity of their prediction into question. NMR work conducted since moreover shows that certain model peptides rather form pleated and not rippled β-sheets in solution. To determine whether the periodic rippled β-sheet layer configuration is viable, the field urgently needs crystal structures. Here we report on crystal structures of two racemic and one quasi-racemic aggregating peptide systems, all of which yield periodic rippled antiparallel β-sheet layers that are in excellent agreement with the predictions by Pauling and Corey. Our study establishes the rippled β-sheet layer configuration as a motif with general features and opens the road to structure-based design of unique supramolecular architectures.
Aluminum ions stimulate the oxidizability of low density lipoprotein by Fe2+: Implication in hemodialysis mediated atherogenic LDL modification (2005)

The results indicate that increased LDL oxidation by Fe(2+) in presence of Al(3+) might be due to blockage of Fe(2+) binding sites on LDL making more free Fe(2+) available for lipid oxidation.
Effect of Nanoporous Structure on Enhanced Electrochemical Reaction (2010)

Geometric factors affecting the enhanced electrocatalysis on nanoporous Pt (L2-ePt) were examined by electrochemical methods and computer simulations. The experimental results revealed that the electrochemical enhancement of O2 and H2O2 does not come only from expansion of the active surface area (so-called roughness factor, fR) of L2-ePt. The presence of extra contribution was verified by the fact that significant enhancement in electrocatalytic reactions remained even after the effect of the fR was eliminated from the electrochemical redox behavior of O2 and H2O2 on L2-ePt electrodes. Not only the voltammetric observation but also potentiometric pH responses of L2-ePt suggested the presence of unique nanoporous effects other than the surface enlargement in regard to heterogeneous electrochemical reactions. L2-ePt showed near Nernstian behavior, faster response time, and less hysteresis even if the real surface area was smaller than that of flat Pt. Increased residence time near the electrode surface due to extremely confined space of nanoporous structure was proposed as possible origins and examined by the Monte Carlo simulations of simple model electrodes. The theoretical approaches indicated that long residence time of reactant at electrode surface by confinement effect of the nanoporous environment well accounted for the experimental results.