gebhart/patrepeval huggingface dataset:
Inhibition of DNA Synthesis by a Small-Cell Lung Carcinoma-Derived Protein (1986)

A tumor-derived factor that inhibits cellular DNA synthesis was identified. The factor was extractable from a small-cell lung carcinoma cell line grown in either chemically defined medium or nu/nu mice and inhibited tritiated thymidine ([3H]dThd) incorporation by tumor cell lines of autologous, allogeneic, and xenogeneic origins. The viability of nonproliferating cells from normal tissue was not affected. Tumor extract inhibitory activity was trypsin labile but was resistant to other proteases, neuraminidase, lipase, DNase, RNase, glucosidase, extremes of pH-temperature, and reducing conditions. Inhibitory activity was reversibly bound to helix pomatia lectin but not to lentil, wheat germ, or concanavalin A lectins. Purification by size-exclusion high-performance liquid chromatography yielded a bioactive unimodal 12-kilodalton (kd) peak. The bioactive 12-kd moiety could be eluted from sodium dodecyl sulfate-polyacrylamide gels. Redosing of populations of the T-lymphoblastoid cell line CEM achieved an early (24 hr) sustained depression of pulse [3H]dThd incorporation and ultimately led to decreased population density of factor-treated populations. DNA histogram analysis demonstrated no change in cell cycle phase distribution after factor treatment. 5-Bromo-2'-deoxyuridine (BrdUrd) vs. propidium iodide with the two-parameter Fluorescence-Activated Cell Sorter analysis showed relative inhibition of non-S-phase BrdUrd uptake at 24 hours. A cell-free DNA polymerase assay demonstrated significant inhibition of non-alpha-polymerase-associated DNA synthesis in factor-treated cells. These studies suggest that this tumor-derived inhibitor of DNA synthesis represents a class of cellular products involved in the autoregulation of growth by regulation of DNA synthetic activity.
The AtSUC1 sucrose carrier may represent the osmotic driving force for anther dehiscence and pollen tube growth in Arabidopsis (1999)

The Arabidopsis AtSUC1 protein has previously been characterized as a plasma membrane H+-sucrose symporter. This paper describes the sites of AtSUC1 gene expression and AtSUC1 protein localization and assigns specific functions to this sucrose transporter in anther development and pollen tube growth. RNase protection assays revealed AtSUC1 expression exclusively in floral tissue, which was confirmed by analyses of AtSUC1 promoter-beta-glucuronidase (GUS) plants. In situ hybridizations identified AtSUC1 expression in anther connective tissue, in funiculi and in fully developed pollen grains. Indirect immuno-fluorescence analyses with anti-AtSUC1 antiserum confirmed AtSUC1 protein localization in the connective tissue and funiculi. In mature pollen grains, however, despite high AtSUC1 mRNA levels no AtSUC1 protein was found. Only after pollination of stylar papillae was AtSUC1 protein detected inside the pollen and later inside the growing pollen tubes, suggesting a translation of pre-existing AtSUC1 mRNA after pollination. Pollen germination analyses underlined the important role of sucrose for pollen tube growth. The data presented suggest a role of AtSUC1 in the controlled dehiscence of Arabidopsis anthers. It is postulated that an important function of AtSUC1 is the cell-specific modulation of water potentials.
Transient characterization of the electroforming process in TiO2 based resistive switching devices (2013)

The transient electroforming process of TiO2-based resistive switching devices is investigated using a pulsed voltage method, and the electroforming time is found to vary from 10−8 s to 10−1 s as function of pulse magnitude (3–8 V) and ambient temperature (25–100 °C). Pulsed experiments and thermal simulations reveal that Joule self-heating has a significant effect on the electroforming dynamics, specially for electroforming voltages above 5.5 V where there is little dependence on ambient temperature and the electroforming time (10–100 ns) is much shorter than the device thermal time constant (≈2 μs).
Peripheral serotonergic neurons regulate gut motility and anxiety-like behavior (2023)

Abstract Serotonergic circuits in the central nervous system play important roles in regulating mood and behavior, yet the functions of peripheral serotonergic neurons are less understood. Here, we engineered mice lacking the serotonin-producing enzyme Tph2 in peripheral neurons but with intact Tph2 in central neurons. In contrast to mice lacking Tph2 in all neurons, mice lacking Tph2 in peripheral serotonergic neurons did not exhibit increased territorial aggression. However, similar to the total body Tph2 KO mice, the conditional KO animals, exhibited reduced gut motility and decreased anxiety-like behavior. These observations reveal that peripheral serotonergic neurons contribute to control of intestinal motility and anxiety-like behavior and suggest that therapeutics targeting this subset of peripheral neurons could be beneficial.
Highly Diastereoselective Catalytic Meerwein−Ponndorf−Verley Reductions (2005)

[reaction: see text] Very practical synthesis of ephedrine analogues in high yields and enantiopurity was realized by a highly diastereoselective Meerwein-Ponndorf-Verley (MPV) reduction of protected alpha-amino aromatic ketones using catalytic aluminum isopropoxide. The high anti selectivity resulted from the chelation of the nitrogen anion to the aluminum. In contrast, high syn selectivity was obtained with alpha-alkoxy ketones and other compounds via Felkin-Ahn control.
Review of Kraft paper/natural ester fluid insulation system aging (2011)

We examine the results of recent Kraft paper/natural ester fluid insulation system sealed tube aging studies. The initial rates of cellulose degradation of Kraft and thermally upgraded Kraft in mineral oil or natural esters are similar. Subsequent degradation in natural ester occurs at a slower rate. This appears to be true for both plain and thermally upgraded Kraft. Based on early sealed tube aging results, the insulation unit life of the natural ester/thermally upgraded Kraft insulation system is estimated to be 130°C. Accelerated aging of single phase distribution transformers filled with natural ester also show a reduction using a thermally upgraded Kraft/natural ester insulation system, meeting criteria for 120°C hottest spot temperature operation.
Cortical Representation of Interaural Time Difference Is Impaired by Deafness in Development: Evidence from Children with Early Long-term Access to Sound through Bilateral Cochlear Implants Provided Simultaneously (2017)

Accurate use of interaural time differences (ITDs) for spatial hearing may require access to bilateral auditory input during sensitive periods in human development. Providing bilateral cochlear implants (CIs) simultaneously promotes symmetrical development of bilateral auditory pathways but does not support normal ITD sensitivity. Thus, although binaural interactions are established by bilateral CIs in the auditory brainstem, potential deficits in cortical processing of ITDs remain. Cortical ITD processing in children with simultaneous bilateral CIs and normal hearing with similar time-in-sound was explored in the present study. Cortical activity evoked by bilateral stimuli with varying ITDs (0, ±0.4, ±1 ms) was recorded using multichannel electroencephalography. Source analyses indicated dominant activity in the right auditory cortex in both groups but limited ITD processing in children with bilateral CIs. In normal-hearing children, adult-like processing patterns were found underlying the immature P1 (∼100 ms) response peak with reduced activity in the auditory cortex ipsilateral to the leading ITD. Further, the left cortex showed a stronger preference than the right cortex for stimuli leading from the contralateral hemifield. By contrast, children with CIs demonstrated reduced ITD-related changes in both auditory cortices. Decreased parieto-occipital activity, possibly involved in spatial processing, was also revealed in children with CIs. Thus, simultaneous bilateral implantation in young children maintains right cortical dominance during binaural processing but does not fully overcome effects of deafness using present CI devices. Protection of bilateral pathways through simultaneous implantation might be capitalized for ITD processing with signal processing advances, which more consistently represent binaural timing cues.<b>SIGNIFICANCE STATEMENT</b> Multichannel electroencephalography demonstrated impairment of binaural processing in children who are deaf despite early access to bilateral auditory input by first finding that foundations for binaural hearing are normally established during early stages of cortical development. Although 4- to 7-year-old children with normal hearing had immature cortical responses, adult patterns in cortical coding of binaural timing cues were measured. Second, children receiving two cochlear implants in the same surgery maintained normal-like input from both ears, but this did not support significant effects of binaural timing cues in either auditory cortex. Deficits in parieto-occiptal areas further suggested impairment in spatial processing. Results indicate that cochlear implants working independently in each ear do not fully overcome deafness-related binaural processing deficits, even after long-term experience.
A view of database system performance measures (1987)

Database systems allow quick creation of performance problems. The goal of database systems is to allow the computer-illiterate to write complex and complete applications. It is the job of the system to translate a high-level description of data and procedures into efficient algorithms. The REAL performance metric of a system is how successfully it meets these goals.
A Reliable and Power Efficient Beacon Structure for Cognitive Radio Systems (2008)

In this paper, an energy efficient structure for beacon signal transmission is proposed for incumbent wireless microphone protection in a cognitive radio system. The proposed structure consists of two consecutive parts: Synchronization with Index and Synchronization with Payload, transmitted as in-phase and quadrature components respectively. As opposed to the current beacon design, it can achieve more reliable and balanced error protection for the beacon components, while keeping the system complexity low.
On-Rate (2016)

Biomolecular screening is now a crucial component of the drug discovery process, and this glossary will be of use to practitioners in the field of screening and to those who interact with the screening community. The glossary contains definitions related to various aspects of the screening process such as assay types, data handling, and relevant technologies. Many of the terms used in this discipline are not covered by existing glossaries, and where they are, the definitions are often not appropriate for this field. Where appropriate, this document provides new or modified definitions to better reflect the new context. The field of biomolecular screening is multidisciplinary in nature, and this glossary, containing authoritative definitions, will be useful not only for regular practitioners, but also for those who make use of data generated during the screening process.
The effects of selenium feed supplements on the oxidative stability indicators of egg yolk during the laying period (2021)

The aim of this study was to assess the effects of four types of selenium (Se) feed supplements on the indicators of the oxidative stability of egg yolk. A total of 1,740 Bovans Brown laying hens were divided into 4 experimental and 1 control group. The diets fed to the experimental groups were supplemented with 0.2 mg/kg of Se, provided as sodium selenite, Se-enriched yeast, synthetic L-selenomethionine and hydroxy-analogue of selenomethionine. The highest concentrations of MDA, an indicator of secondary lipid oxidation, were confirmed in the Control Group eggs ( P &lt; 0.001). Egg yolks from the Control Group were found to have the highest lightness ( P = 0.032), the lowest colour chroma and the lowest proportions of the red and yellow colours ( P &lt; 0.001). The highest vitelline membrane strength was measured in eggs from groups fed diets supplemented with organic Se ( P &lt; 0.001). No significant differences were found between groups in the total fatty acid content, the content of saturated and unsaturated fatty acids or the n-6/n-3 fatty acid ratios. Our study confirmed the effect of Se feed supplements on the concentration of MDA and the colour indicators of egg yolk and on the vitelline membrane strength.
The use of PROMIS CAT Physical Function Pre-surgical Scores to Predict Recovery and Establish Pre-surgical Cut-off Values (2017)

Objectives: There is a lack of standardized outcome measures or methods to study the effects of treatment and to effectively monitor and document patient outcomes. We have used Patient Reported Outcome Measurement Information System (PROMIS) computed adaptive testing questionnaires collected during routine office visits to describe the pre-surgical and postsurgical physical function scores and to assess the ability of pre-surgical scores to predict scores at 6 month after surgery. Methods: A retrospective analysis of 619 patients undergoing ACL reconstructive surgery at a large academic medical system was conducted to compare the predictive value of baseline PROMIS physical function scores to predict those scores after surgery. Patients with PROMIS physical Function scores within 1 standard deviation of the normal population at baseline were compare to those who fell below that score. Longitudinal comparisons of PROMIS scores between subsets was then made to identify any significant differences. PROMIS scores were assessed for discriminatory ability using receiver operating characteristic (ROC) curve analyses, with overall accuracy summarized using the area under the ROC curve (AUC). Nonparametric estimates and 95% confidence intervals for the AUC were used for each measurement at similar time points. Results: As shown in figure 1 average PROMIS physical function scores at later timepoints were comparable to those who had higher baseline scores. An ANOVA general linear (GROUP x TIME) model found statically significant (p&lt;. 001) differences between the two groups at earlier time points. Further, ROC curve analysis demonstrated that PROMIS physical function scores have moderate to strong predictive ability (AUC&gt;0.826). Using the ROC analysis an “optimal” cut-off pre-surgical score was determined to be a T-Score of 42.6. Conclusion: If fully utilized, these outcome measures can help inform physicians in individual surgical cases, as well as be used to show overall practice trends. Early identification of potential poor outcomes after ACL reconstruction may result in ability to intervene earlier to prevent prolonged disability. This investigation into the use of PROMIS physical function assessment tools has shown some utility in the ability to discriminate between those individuals who go on to have a full recovery over a typical recovery timeline and those who go on to have slower recovery.
Ataxia-Telangiectasia With Hyper-IgM and Wilms Tumor: Fatal Reaction to Irradiation (2009)

Ataxia-telangiectasia is an autosomal recessive disorder caused by mutation in the ATM gene. Hallmarks of the disease comprise progressive cerebellar ataxia, oculocutaneous telangiectasiae, cancer susceptibility, and variable humoral and cellular immunodeficiency. We report a patient who, because of the pattern of her immunodeficiency, was primarily diagnosed as an autosomal recessive hyper-IgM syndrome. Only a mild cerebellar ataxia was present at the age of 7 years then she developed a Wilms tumor (nephroblastoma). Conventional radiotherapy for the malignancy led to fatal consequences. Postmortem studies confirmed diagnosis of ataxia-telangiectasia.
BACE1 is a newly discovered protein secreted by the pancreas which cleaves enteropeptidase in vitro. (2009)

We hypothesize that enteropeptidase is a BACE1 substrate in vivo. If so, BACE1 could protect the pancreas from premature trypsinogen activation due to the occasionally occurring reflux of enteropeptidase.
Letter from the Editor (2013)

Recent advances in using mouse genetic models to study different diseases in humans have unexpectedly advanced studies in spermatogenesis. 2] This also illustrates that there are a lot of data in the literature that remain to be thoughtfully connected. This task of data mining is crucial to better understand spermatogenesis. Therefore, much work is needed to sort through these data to identify crucial functional studies so that better experiments can be designed and conducted. It is our hope that Spermatogenesis, besides publishing novel and informative findings, can serve as the media to highlight some of this important information.
Polarization resolved angular optical scattering of aerosol particles (2014)

Real-time detection and identification of bio-aerosol particles are crucial for the protection against chemical and biological agents. The strong elastic light scattering properties of airborne particles provides a natural means for rapid, non-invasive aerosol characterization. Recent theoretical predictions suggested that variations in the polarization dependent angular scattering cross section could provide an efficient means of classifying different airborne particles. In particular, the polarization dependent scattering cross section of aggregate particles is expected to depend on the shape of the primary particles. In order to experimentally validate this prediction, we built a high throughput, sampling system, capable of measuring the polarization resolved angular scattering cross section of individual aerosol particles flowing through an interrogating volume with a single shot of laser pulse. We calibrated the system by comparing the polarization dependent scattering cross section of individual polystyrene spheres with that predicted by Mie theory. We then used the system to study different particles types: Polystyrene aggregates composed 500 nm spheres and <i>Bacillus subtilis</i> (<i>BG, Anthrax simulant</i>) spores composed of elongated 500 nm × 1000 nm cylinder-line particles. We found that the polarization resolved scattering cross section depends on the shape of the constituent elements of the aggregates. This work indicates that the polarization resolved scattering cross section could be used for rapid discrimination between different bio-aerosol particles.
Hawthorn Evokes a Potent Anti-Hyperglycemic Capacity in Streptozotocin-Induced Diabetic Rats (2003)

The hypoglycaemic effect of an aqueous extract of hawthorn leaves (Crataegus oxyacantha) was investigated in normal and streptozotocin (STZ) diabetic rats. After a single dose or 9 daily doses, oral administration of the aqueous extract produced a significant and dose-dependent decrease on blood glucose levels in STZ diabetic rats (P < 0.001), but had no effect on blood glucose levels in normal rats. No changes were observed in basal plasma insulin concentrations after treatment in normal or STZ diabetic rats. In addition, the acute toxicity study of the extract was investigated in mice. The results obtained showed that the aqueous extract had a high LD50 value (13.5 g/kg) in mice. We conclude that an aqueous extract of hawthorn leaves exhibits a potent anti-hyperglycemic activity in STZ rats, but not in normal rats, without affecting basal plasma insulin concentrations.
Quality Based Handoff in DVB-H Systems Assisted by Cellular Network (2008)

This paper introduces a novel seamless handoff approach for DVB-H networks aimed at reducing the user terminal power consumption and at making the handoff algorithm be driven by the quality of the user received signal. This implies the substitution of standard RSSI-based procedures with a method based on the Modulation Error Rate (MER) monitoring. The additional use of an underlying cellular network, for DVB-H related data delivering, allows to achieve additional advantages: a superior power saving and a faster handoff execution. Obtained results suggest that the DVB-H handoff protocol design is an issue, which definitely deserves further investigation in the view of making DVB-H an effective solution for delivering broadcast content to mobile users.
Azafulvenium methides: new extended dipolar systems (2000)

The transient 8π 1,7-dipolar azafulvenium methides 5 and 8 undergo sigmatropic [1,8] H shifts and the acyl derivatives 12 electrocyclise to give novel pyrrolooxazines 13; the related diazafulvenium methide 15 can be intercepted in 8π + 2π cycloadditions with silylated acetylenes.
Enhancement of flux and solvent stability of Matrimid® thin‐film composite membranes for organic solvent nanofiltration (2014)

The development of high flux and solvent‐stable thin‐film composite (TFC) organic solvent nanofiltration (OSN) membranes was reported. A novel cross‐linked polyimide substrate, consisting of a thin skin layer with minimum solvent transport resistance and a sponge‐like sublayer structure that could withstand membrane compaction under high‐pressure was first fabricated. Then the solvent flux was significantly enhanced without compromising the solute rejection by the coupling effects of (1) the addition of triethylamine/camphorsulfonic acid into the monomer solution, and (2) the combined post‐treatments of glycerol/sodium dodecyl sulphate immersion and dimethyl sulfoxide (DMSO) filtration. Finally, the long‐term stability of the TFC membrane in aprotic solvents such as DMSO was improved by post‐crosslink thermal annealing. The novel TFC OSN membrane developed was found to have superior rejection to tetracycline (MW: 444 g/mol) but was very permeable to alcohols such as methanol (5.12 lm −2 h −1 bar −1 ) and aprotic solvents such as dimethylformamide (3.92 lm −2 h −1 bar −1 ) and DMSO (3.34 lm −2 h −1 bar −1 ). © 2014 American Institute of Chemical Engineers AIChE J , 60: 3623–3633, 2014
Etude de la chaleur dégagée par des cultures microbiennes dans un fermenteur de laboratoire (1986)

These Ecole polytechnique federale de Lausanne EPFL, n° 612 (1986) Reference doi:10.5075/epfl-thesis-612Print copy in library catalog Record created on 2005-03-16, modified on 2016-08-08
Specific Structural Motifs Determine TRAP220 Interactions with Nuclear Hormone Receptors (2000)

The TRAP coactivator complex is a large, multisubunit complex of nuclear proteins which associates with nuclear hormone receptors (NRs) in the presence of cognate ligand and stimulates NR-mediated transcription. A single subunit, TRAP220, is thought to target the entire complex to a liganded receptor through a domain containing two of the signature LXXLL motifs shown previously in other types of coactivator proteins to be essential for mediating NR binding. In this work, we demonstrate that each of the two LXXLL-containing regions, termed receptor binding domains 1 and 2 (RBD-1 and RBD-2), is differentially preferred by specific NRs. The retinoid X receptor (RXR) displays a weak yet specific activation function 2 (AF2)-dependent preference for RBD-1, while the thyroid hormone receptor (TR), vitamin D(3) receptor (VDR), and peroxisome proliferator-activated receptor all exhibit a strong AF2-dependent preference for RBD-2. Using site-directed mutagenesis, we show that preference for RBD-2 is due to the presence of basic-polar residues on the amino-terminal end of the core LXXLL motif. Furthermore, we show that the presence and proper spacing of both RBD-1 and RBD-2 are required for an optimal association of TRAP220 with RXR-TR or RXR-VDR heterodimers bound to DNA and for TRAP220 coactivator function. On the basis of these results, we suggest that a single molecule of TRAP220 can interact with both subunits of a DNA-bound NR heterodimer.