gebhart/patrepeval huggingface dataset:
Evidence That Two ATP-Dependent (Lon) Proteases in Borrelia burgdorferi Serve Different Functions (2009)

The canonical ATP-dependent protease Lon participates in an assortment of biological processes in bacteria, including the catalysis of damaged or senescent proteins and short-lived regulatory proteins. Borrelia spirochetes are unusual in that they code for two putative ATP-dependent Lon homologs, Lon-1 and Lon-2. Borrelia burgdorferi, the etiologic agent of Lyme disease, is transmitted through the blood feeding of Ixodes ticks. Previous work in our laboratory reported that B. burgdorferi lon-1 is upregulated transcriptionally by exposure to blood in vitro, while lon-2 is not. Because blood induction of Lon-1 may be of importance in the regulation of virulence factors critical for spirochete transmission, the clarification of functional roles for these two proteases in B. burgdorferi was the object of this study. On the chromosome, lon-2 is immediately downstream of ATP-dependent proteases clpP and clpX, an arrangement identical to that of lon of Escherichia coli. Phylogenetic analysis revealed that Lon-1 and Lon-2 cluster separately due to differences in the NH(2)-terminal substrate binding domains that may reflect differences in substrate specificity. Recombinant Lon-1 manifested properties of an ATP-dependent chaperone-protease in vitro but did not complement an E. coli Lon mutant, while Lon-2 corrected two characteristic Lon-mutant phenotypes. We conclude that B. burgdorferi Lons -1 and -2 have distinct functional roles. Lon-2 functions in a manner consistent with canonical Lon, engaged in cellular homeostasis. Lon-1, by virtue of its blood induction, and as a unique feature of the Borreliae, may be important in host adaptation from the arthropod to a warm-blooded host.
Psychotomimesis Mediated by κ Opiate Receptors (1986)

The kappa opioid agonists are analgesics that seem to be free of undesired morphine-like effects. Their dysphoric actions observed with the kappa agonist cyclazocine are thought to be mediated by an action at sigma-phencyclidine receptors. The benzomorphan kappa agonist MR 2033 is inactive at sigma-phencyclidine receptors. In male subjects, the opiate-active (-)-isomer, but not the (+)-isomer, elicited dose-dependent dysphoric and psychotomimetic effects that were antagonized by naloxone. Thus, kappa opiate receptors seem to mediate psychotomimetic effects. In view of the euphorigenic properties of mu agonists, our results imply the existence of opposed opioid systems affecting emotional and perceptual experiences.
Simultaneous stereo-motion fusion and 3-D motion tracking (2002)

Presents a new framework for combining maximum likelihood (ML) stereo-motion fusion with adaptive iterated extended Kalman filtering (IEKF) for 3-D motion tracking. The ML stereo-fusion step, with two stereo-pairs, generates observations of 3-D feature matches to be used by the IEKF step. The IEKF step, in turn, computes updated 3-D motion parameter estimates to be used by the ML stereo-motion fusion step. The covariance of the observation noise process is regulated by the value of the ML cost function to address occlusion related problems. The proposed simultaneous approach is compared with performing the 3-D feature correspondence estimation and the Kalman filtering separately using simulated stereo imagery.
Efficient syntheses of 6-prenylcoumarins and linear pyranocoumarins: Total synthesis of suberosin, toddaculin, O-methylapigravin (O-methylbrosiperin), O-methylbalsamiferone, dihydroxanthyletin, xanthyletin and luvangetin (2002)

Synthesis of naturally occurring 6-prenylcoumarins (1a, 2c and 3a) and their derivatives 1c, 1d, 1e, 2d and 3b–d starting from 2-prenyloxybenzaldehydes (8, 12 and 14) using tandem Claisen rearrangement and Wittig reaction is described. The coumarins 1a, 1e and 2c are converted to dihydropyranocoumarins (5a–e). The conversion of dihydroxanthyletin 5a and dihydroluvangetin 5d to the naturally occurring linear pyranocoumarins xanthyletin 6a and luvangetin 6b is also described.
PARP-1 suppresses adiponectin expression through poly(ADP-ribosyl)ation of PPARγ in cardiac fibroblasts (2008)

PARP-1 inhibits adiponectin and AdipoR1 expression as well as PPAR gamma transactivation through poly(ADP-ribosyl)ation of PPAR gamma in cultured rat cardiac fibroblasts.
CONFIRMATION OF CATFISH MORTALITIES RESULTING FROM MICROCYSTIN PRODUCED DURING MICROCYSTIS BLOOMS (2000)

Enigmatic deaths of finfish have occurred in freshwater systems for many years. Some of these fish mortalities can be attributed to the accumulation of cyanobacterial toxins during ingestion of floating feeds or passively through opercular ventilation. We recently were able to document the accumulation of microcystin and resulting catastrophic mortality of pond‐raised catfish ( Ictalurus punctatus ). The causative organism, Microcystis aeruginosa , was the dominant phytoplankton component within the cooler fall‐winter season. Microcystin, a hepatotoxin produced by Microcystis , was detected in water and catfish liver samples. Fish exposed to pond water containing this bloom were killed within 24 h. Necropsy of fish exposed to pond water revealed congested liver and spleen tissues. Environmental conditions associated with several similar bloom events suggest several predictive options to forecast conditions supporting toxin formation, particularly temperature.
Boundary Troubles (2016)

We stage a dialogue between two areas of growing interest in HCI: making cultures and research through design. Both have only recently gained momentum, and so each of their proponents are demarcating--often too sharply--who and what is to be included in their programs to legitimate their work as a concern of and contribution to HCI. Drawing from diverse engagements with making and research through design, the panelists and discussant will explore positions concerning the relationship between research, design, and making. An underlying goal of the panel is to revisit the inclusionary and exclusionary impulses central to the necessary activities of research agenda formation, theory and methodology construction, and legitimation for both making and research through design.
Requirement of zinc transporter ZIP10 for epidermal development: Implication of the ZIP10–p63 axis in epithelial homeostasis (2017)

Skin tissues, in particular the epidermis, are severely affected by zinc deficiency. However, the zinc-mediated mechanisms that maintain the cells that form the epidermis have not been established. Here, we report that the zinc transporter ZIP10 is highly expressed in the outer root sheath of hair follicles and plays critical roles in epidermal development. We found that ZIP10 marked epidermal progenitor cell subsets and that ablating <i>Zip10</i> caused significant epidermal hypoplasia accompanied by down-regulation of the transactivation of p63, a master regulator of epidermal progenitor cell proliferation and differentiation. Both ZIP10 and p63 are significantly increased during epidermal development, in which ZIP10-mediated zinc influx promotes p63 transactivation. Collectively, these results indicate that ZIP10 plays important roles in epidermal development via, at least in part, the ZIP10-zinc-p63 signaling axis, thereby highlighting the physiological significance of zinc regulation in the maintenance of skin epidermis.
Abstract GS3-06: Biomarker evaluation in the phase 3 ASCENT study of sacituzumab govitecan versus chemotherapy in patients with metastatic triple-negative breast cancer (2021)

Abstract Background: Trophoblast cell-surface antigen-2 (Trop-2) is highly expressed in many epithelial tumors, including triple-negative breast cancer (TNBC). Sacituzumab govitecan (SG) is an antibody-drug conjugate composed of an anti-Trop-2 antibody coupled to SN-38, an active metabolite of irinotecan, via a unique hydrolyzable linker that allows for SN-38 release intracellularly and in the tumor microenvironment (bystander effect). Preclinical studies have shown a great range of efficacy with SG in mice bearing tumors with low, moderate, and high Trop-2 expression levels. We report subgroup analyses by Trop-2 expression from ASCENT, a randomized, phase 3 confirmatory study of SG versus standard-of-care chemotherapy in patients with metastatic TNBC (mTNBC). Methods: In the global, multicenter, open-label, phase 3 ASCENT study (NCT02574455), 529 patients with mTNBC refractory to or relapsing after at least 2 prior chemotherapies were randomized 1:1 to receive SG (10 mg/kg intravenously on days 1 and 8 every 21 days) or single-agent treatment of physician’s choice (capecitabine, eribulin, vinorelbine, or gemcitabine) until disease progression or unacceptable toxicity. The primary endpoint was progression-free survival (PFS) measured by central independent review per RECIST v1.1. Secondary endpoints included objective response rate (ORR) per RECIST v1.1, duration of response, overall survival (OS), and safety. Exploratory endpoints included biomarker assessments, including Trop-2 and BRCA1/2. Trop-2 expression was assessed using a validated immunohistochemistry assay. Results: Subgroup analyses by biomarker expression including Trop-2 and BRCA1/2 were performed, and outcomes by PFS, OS, ORR, and safety results will be reported. Conclusions: These analyses will provide further insights into the relationship of Trop-2 expression and the activity of SG in previously treated patients with mTNBC. Citation Format: Sara A. Hurvitz, Sara M. Tolaney, Kevin Punie, Delphine Loirat, Mafalda Oliveira, Kevin Kalinsky, Amelia Zelnak, Philippe Aftimos, Florence Dalenc, Sagar Sardesai, Erika Hamiltion, Priyanka Sharma, Sabela Recalde, Eva Ciruelos Gil, Tiffany Traina, Joyce O'Shaughnessy, Javier Cortés, Michaela Tsai, Linda Vahdat, Véronique Diéras, Lisa Carey, Hope S. Rugo, David M. Goldenberg, Quan Hong, Martin Olivo, Loretta M. Itri, Aditya Bardia. Biomarker evaluation in the phase 3 ASCENT study of sacituzumab govitecan versus chemotherapy in patients with metastatic triple-negative breast cancer [abstract]. In: Proceedings of the 2020 San Antonio Breast Cancer Virtual Symposium; 2020 Dec 8-11; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2021;81(4 Suppl):Abstract nr GS3-06.
Dare I Embark On A Field Study? Toward An Understanding Of Field Studies (2015)

Field studies have frequently been advocated as a means for understanding cognitive activities in naturalistic settings. However, there are several fundamental obstacles that one has to overcome to conduct a field study. This paper discusses two of these obstacles in the context of studying problem solving in complex environments: defining goals of a field study and justifying methods used in data analysis. Based on our experience from a recently finished field study, we outline a framework for understanding the nature of field studies and suggest a specific approach to data analysis. We argue that the goal of field studies should not be limited to hypothesis testing, and that the process of data analysis in field studies can be viewed as an inductive abstraction process. Our field study is used to illustrate the abstraction approach to data analysis and how the obstacles in field studies were dealt with. Through these discussions, we encourage researchers to engage in more field studies.
Extraction et activité psychotrope de l’huile essentielle de la verveine odorante Lippia citriodora (2015)

Parmi les plantes traditionnellement utilisées au Maroc pour réduire la nervosité et favoriser l’endormissement est fréquemment retrouvée la verveine odorante (Lippia citriodora H.B. et K./ V. Triphylla L’Her), connue en arabe sous le nom de louisa. Elle est utilisée traditionnellement en infusion surtout pour ses propriétés sédatives et myorelaxantes, essentiellement chez le nouveau-né. Notre travail a pour objectif d’extraire l’huile essentielle (HE) de la partie aérienne de la verveine odorante, d’identifier la composition de l’HE de cette dernière par chromatographie en phase gazeuse couplée à un spectromètre de masse et d’étudier l’activité psychotrope de l’huile essentielle (HE) grâce à une batterie de tests comportementaux utilisés en psychopharmacologie. Les résultats de cette étude démontrent une richesse de principes actifs à rapprocher du potentiel sédatif de l’HE de la verveine odorante (Lippia citriodora H.B.K), laissant prévoir une utilisation dans le traitement de l’angoisse, du stress et de l’insomnie pour son effet sédatif avec une sécurité d’emploi à des doses thérapeutiques.
LPS Promotes Pre-osteoclast Activity by Up-regulating CXCR4 via TLR-4 (2011)

Lipopolysaccharide (LPS) has been shown to be a prominent pathogenic factor in inflammatory bone loss. However, knowledge of the mechanisms involved is limited. The role of the SDF-1/CXCR4 (Stromal-derived factor-1 and its unique chemokine receptor) axis in LPS-induced bone loss has not been studied. The aim of this study was to investigate the role of the SDF-1/CXCR4 axis in LPS-stimulated inflammatory bone loss. The results show that LPS does not influence the expression of SDF-1/CXCR4 in osteoblasts, but up-regulates the expression of CXCR4 in pre-osteoclasts via Toll-like receptor 4, which subsequently enhances pre-osteoclast migration. Moreover, LPS promoted RANKL-induced osteoclast differentiation partially through CXCR4 up-regulation. In conclusion, the present study demonstrated, for the first time, that the up-regulated expression of CXCR4 in pre-osteoclasts by LPS stimulation is involved in LPS-induced bone resorption.
Vehicle track detection in CCD imagery via conditional random field (2015)

Coherent change detection (CCD) can indicate subtle scene changes in synthetic aperture radar (SAR) imagery, such as vehicle tracks. Automatic track detection in SAR CCD is difficult due to various sources of low coherence other than the track activity we wish to detect. Existing methods require user cues or explicit modeling of track structure, which limit algorithms' ability to find tracks that do not fit the model. In this paper, we present a track detection approach based on a pixel-level labeling of the image via a conditional random field classifier, with features based on radial derivatives of local Radon transforms. Our approach requires no modeling of track characteristics and no user input, other than a training phase for the unary cost of the conditional random field. Experiments show that our method can successfully detect both parallel and single tracks in SAR CCD as well as correctly declare when no tracks are present.
Evaluation of fuzzy and neural vehicle control (2003)

The authors present a neural and fuzzy solution to the collision avoidance problem of an automated guided vehicle (AGV). They describe the AGV and its sensor characteristics. Two methods based on neural networks and fuzzy logic, respectively, have been developed. The advantages and problems of each approach are evaluated. Experiments showed that the collision avoidance problem can be successfully tackled by both neural networks and fuzzy logic. Both approaches have the advantage that almost no control-specific knowledge is needed. Neural network controllers are easier to design, whereas the operation of the fuzzy logic controller is more understandable, i.e., individual rules can be adjusted to optimize certain parts of the controller behavior.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Gas Sensor for Volatile Anesthetic Agents Based on Raman Scattering (2012)

Continuous monitoring of respiratory and anesthetic gases during a surgery is of vital importance for the patient safety. Commonly the gas composition is determined by gas chromatography or a combination of IR-spectroscopy and electrochemical sensors. This study presents a concept for an optical sensor based on spontaneous Raman scattering which offers several advantages compared to established systems. All essential components can be detected simultaneously, no sample preparation is necessary and it provides fast response times. To reach the performance of a commonly used gas monitor signal gain has to be increased e.g. by using a multi pass setup.
Catalyst studies for hydrogenation of vegetable oils (1969)

Abstract Cottonseed and soybean oils were partially hydrogenated using various commercial nickel catalysts. Methods were investigated by which commercial catalysts can be changed with respect to the rate of reaction, selectivity or trans ‐isomerization during hydrogenation of the oils. Catalysts which were treated with hydrogen sulfide produce considerably more trans isomers but catalysts treated with air often cause higher selectivity ratios. Factors affecting the hydrogenation characteristics of a catalyst are discussed.
Open-Label, Dose Run-Up Study of Diethylpropion in Initial Cocaine Abstinence (1994)

An open-label, dose run-up clinical trial of diethylpropion, a mild psychostimulant medication with an approved indication for the short-term treatment of exogenous obesity, was conducted in 10 cocaine dependent patients. A “cocaine agonist” strategy has been proposed as a potential pharmacotherapy to assist in the initiation of cocaine abstinence in severely dependent patients. Diethylpropion exhibits many of the desirable properties of a medication with cocaine agonist properties. The current trial was conducted to obtain preliminary data on the safety, tolerability and efficacy of diethylpropion in cocaine dependent patients. Moreover, the study was conducted to obtain guidelines for dosing in future clinical trials. The results of this preliminary study suggest possible anti-craving efficacy and mood elevating properties for diethylpropion in this population. However, side effects were noted. Although most were not of a serious nature, one involved the precipitation of a manic episode. Nevertheless, because of diethylpropion's potential clinical efficacy in this population, further cautious investigation of the efficacy of this medication for the treatment of cocaine dependence is indicated.
Tigecycline: A new glycylcycline antimicrobial agent (2006)

Tigecycline is an alternative agent available for the treatment of resistant gram-negative and gram-positive infections, especially in patients with a history of a penicillin allergy or antimicrobial-related toxicities.
Exchange of Interlamellar Cations with Its Aqueous Environment in Charged Layered Systems: Similarity between Clays and Langmuir-Blodgett Films of Metal Salts of Fatty Acids (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTExchange of Interlamellar Cations with Its Aqueous Environment in Charged Layered Systems: Similarity between Clays and Langmuir-Blodgett Films of Metal Salts of Fatty AcidsP. Ganguly, D. V. Paranjape, S. Pal, and Murali SastryCite this: Langmuir 1994, 10, 6, 1670–1672Publication Date (Print):June 1, 1994Publication History Published online1 May 2002Published inissue 1 June 1994https://pubs.acs.org/doi/10.1021/la00018a011https://doi.org/10.1021/la00018a011research-articleACS PublicationsRequest reuse permissionsArticle Views66Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Phase transfer catalyzed synthesis of indazoles from o‐alkylbenzenediazonium tetrafluoroborates (1984)

Abstract Reactions of o ‐methyl‐ and o ‐ethylbenzenediazonium tetrafluoroborates with two equivalents of potassium acetate and five mole percent of 18‐crown‐6 in ethanol‐free chloroform produce indazoles in good to excellent yields. Indazoles bearing either electron‐withdrawing or electron‐donating substituents may be prepared.
Reply to: GPR120 local regulation might explain the contradictory pro/anti-inflammatory effects of ω-3 PUFA observed in gestational tissues (2015)

Article Reply to: GPR120 local regulation might explain the contradictory pro/anti-inflammatory effects of ω-3 PUFA observed in gestational tissues was published on January 1, 2016 in the journal Journal of Perinatal Medicine (volume 44, issue 1).
Total variation norm for three-dimensional iterative reconstruction in limited view angle tomography (2001)

An iterative Bayesian reconstruction algorithm for limited view angle tomography, or ectomography, based on the three-dimensional total variation (TV) norm has been developed. The TV norm has been described in the literature as a method for reducing noise in two-dimensional images while preserving edges, without introducing ringing or edge artefacts. It has also been proposed as a 2D regularization function in Bayesian reconstruction, implemented in an expectation maximization algorithm (TV-EM). The TV-EM was developed for 2D single photon emission computed tomography imaging, and the algorithm is capable of smoothing noise while maintaining edges without introducing artefacts. The TV norm was extended from 2D to 3D and incorporated into an ordered subsets expectation maximization algorithm for limited view angle geometry. The algorithm, called TV3D-EM, was evaluated using a modelled point spread function and digital phantoms. Reconstructed images were compared with those reconstructed with the 2D filtered backprojection algorithm currently used in ectomography. Results show a substantial reduction in artefacts related to the limited view angle geometry, and noise levels were also improved. Perhaps most important, depth resolution was improved by at least 45%. In conclusion, the proposed algorithm has been shown to improve the perceived image quality.
Geometric context from a single image (2005)

Many computer vision algorithms limit their performance by ignoring the underlying 3D geometric structure in the image. We show that we can estimate the coarse geometric properties of a scene by learning appearance-based models of geometric classes, even in cluttered natural scenes. Geometric classes describe the 3D orientation of an image region with respect to the camera. We provide a multiple-hypothesis framework for robustly estimating scene structure from a single image and obtaining confidences for each geometric label. These confidences can then be used to improve the performance of many other applications. We provide a thorough quantitative evaluation of our algorithm on a set of outdoor images and demonstrate its usefulness in two applications: object detection and automatic single-view reconstruction.