gebhart/patrepeval huggingface dataset:
Prenatal nicotine increases testosterone levels in the fetus and female offspring (2003)

Epidemiological studies have shown that smoking during pregnancy markedly increases the risk for future tobacco use by adolescent female offspring. It has been hypothesized that the increased smoking risk in females is secondary to a nicotine-induced increase in fetal plasma testosterone levels that persist to adult life. To test this hypothesis, we randomized pregnant Sprague-Dawley rats to receive either saline or nicotine from Day 4 until the end of gestation. Blood samples for testosterone levels were obtained from 30- and 120-day-old offspring. In addition, blood samples for testosterone levels were obtained prior to and following a 2-day infusion of nicotine to chronically catheterized ovine fetuses. Maternal nicotine exposure resulted in increased plasma testosterone in 30-day-old female rat offspring, with no differences found in nicotine-exposed males. In addition, plasma testosterone levels increased in ovine fetuses in response to the nicotine infusion. We conclude that prenatal nicotine exposure increases plasma testosterone levels chronically in adolescent female rat offspring and acutely in both male and female ovine fetuses. Although our findings lack correlative behavioral information on the female offspring, these data are consistent with human epidemiological data suggesting that prenatal environmental influences may have marked effects on the subsequent smoking behaviors of offspring.
Structural characterization of two polymorphic forms of piroxicam pivalate (1998)

The crystal and molecular structures of two polymorphs of piroxicam pivalate are presented and discussed. A peculiarity of the high melting (154 degrees C) polymorph is the association of piroxicam pivalate molecules as centrosymmetric dimers by hydrogen bonding. Two centrosymmetrically related N-H...N hydrogen bonds maintain the dimer structure involving the amido nitrogen atom as donor and the pyridine nitrogen atom as acceptor. Molecular association of this type does not occur in the crystal structures of drugs belonging to the oxicam class of nonsteroidal antiinflammatory drugs. Two distinct conformations coexist in the crystal of the low melting polymorph (136 degrees C) with differing hydrogen bonding arrangements within domains of the crystallographically independent molecules. The occurrence of different molecular conformations (conformational polymorphism) associated with different hydrogen bonding schemes in discrete domains is an unusual structural feature. Structural data for the two polymorphs are also correlated with the relevant infrared spectra. Computer-generated X-ray powder diffraction patterns for the two polymorphs of piroxicam pivalate are in very good agreement with the experimental ones, thus confirming the validity of the single-crystal X-ray models.
INTEGRATED DESIGN AS AN APPROACH TOWARDS DF (2014)

In this paper, DFA (Design for Assembly) and its associated considerations in micro area are investigated and the differences between the DFA rules for macro and micro manufacturing are discussed. The applicability of conventional DFA rules in micro area and the necessity of defining a set of DF
Measuring the overall genetic component of nevirapine pharmacokinetics and the role of selected polymorphisms (2013)

This study demonstrates that there is a significant genetic component to variability in nevirapine pharmacokinetics. Although genetic variants such as CYP2B6 polymorphisms attributed to some of this variation, these data suggest that there may be additional genetic factors that influence nevirapine pharmacokinetics.
Recent trends in the management of advanced prostate cancer (2018)

Advanced prostate cancer includes a wide spectrum of disease ranging from hormone naïve or hormone sensitive to castration resistant, both containing populations of men who have demonstrable metastatic and non-metastatic states. The mainstay of treatment for metastatic hormone-sensitive prostate cancer is androgen deprivation therapy (ADT). However, recent level 1 evidence demonstrates that the addition of chemotherapy or abiraterone acetate to ADT results in significant survival advantage as compared with ADT alone. Furthermore, in non-metastatic castration-resistant prostate cancer (M0 CRPC), two second-generation anti-androgens, apalutamide and enzalutamide, when used in combination with ADT, have demonstrated a significant benefit in metastasis-free survival. Here, we review the most recent studies leading to these significant changes in the treatment of advanced prostate cancer.
Aurocitrin and Related Polyketide Metabolites from the Wood-Decay Fungus Hypocrea sp. BCC 14122 (2008)

The known gentisaldehyde antibiotic aurocitrin (1), its cis-olefinic isomer (2), a salicylaldehyde analogue (3), two new benzofuran derivatives (4 and 5), and a new dihydroisocoumarin (6) were isolated from the wood-decay fungus Hypocrea sp. BCC 14122. The structures were elucidated primarily by NMR and mass spectroscopic analyses.
Stereo Music Signal Separation Combining Directional Clustering and Nonnegative Matrix Factorization (2012)

ISSPIT 2012: The 12th IEEE International Symposium on Signal Processing and Information Technology, December 12-15, 2012, Ho Chi Minh City, Vietnam.
Bottom-Up Proteomics (2019)

Recommendations are given concerning the terminology of methods of bioanalytical chemistry. With respect to dynamic development particularly in the analysis and investigation of biomacromolecules, terms related to bioanalytical samples, enzymatic methods, immunoanalytical methods, methods used in genomics and nucleic acid analysis, proteomics, metabolomics, glycomics, lipidomics, and biomolecules interaction studies are introduced.
Experimental verification and comparison of different stabilizing controllers for a rotary inverted pendulum (2013)

This paper focuses on implementation of swing-up, switching and stabilizing controllers for rotary inverted pendulum. An energy based method to swing-up the pendulum and a state feedback controller to keep the pendulum in the upright position are employed. The mixed H <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> /H <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">∞</inf> state feedback controller is used to stabilize the pendulum with reduced oscillations. The results have been compared with the standard full state feedback and LQR. The Quanser rotary inverted pendulum is used as the testbed. All controllers are implemented in real-time using Microstick II with dsPIC33FJ128MC802 and Simulink embedded target for Microchip <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">®</sup> .
Multi-view Video Coding with View Scalability (2007)

In this paper, we propose a multi-view coding(MVC) algorithm with considering view scalability. The proposed algorithm has a high compression efficiency by reducing inter-view redundancy through inter-view decomposition, and adaptively reconstructs a multi-view video from an encoded bit stream. Furthermore, a reference view can be decoded by a traditional H.264/AVC, and the other views are adaptively decoded at the receiver by filtering to support view scalability. Experimental results show that the proposed algorithm performed better than the conventional H.264 codec even though it offers the view scalability.
Response Binning: Improved Weak Classifiers for Boosting (2006)

This paper demonstrates the value of improving the discriminating strength of weak classifiers in the context of boosting by using response binning. The reasoning is centered around, but not limited to, the well known Haar-features used by Viola and Jones (2001) in their face detection/pedestrian detection systems. It is shown that using a weak classifier based on a single threshold is sub-optimal and in the case of the Haar-feature inadequate. A more general method for features with multi-modal responses is derived that is easily used in boosting mechanisms that accepts a confidence measure, such as the RealBoost algorithm. The method is evaluated by boosting a single stage classifier and compare the performance to previous approaches
The Malina oceanographic expedition: How do changes in ice cover, permafrost and UV radiation impact biodiversity and biogeochemical fluxes in the Arctic Ocean? (2020)

Abstract. The MALINA oceanographic campaign was conducted during summer 2009 to investigate the carbon stocks and the processes controlling the carbon fluxes in the Mackenzie River estuary and the Beaufort Sea. During the campaign, an extensive suite of physical, chemical and biological variables was measured across seven shelf–basin transects (south-north) to capture the meridional gradient between the estuary and the open ocean. Key variables such as temperature, absolute salinity, radiance, irradiance, nutrient concentrations, chlorophyll-a concentration, bacteria, phytoplankton and zooplankton abundance and taxonomy, and carbon stocks and fluxes were routinely measured onboard the Canadian research icebreaker CCGS Amundsen and from a barge in shallow coastal areas or for sampling within broken ice fields. Here, we present the results of a joint effort to tidy and standardize the collected data sets that will facilitate their reuse in further studies of the changing Arctic Ocean. The dataset is available at https://doi.org/10.17882/75345 (Massicotte2020b).
High power ultrafast excimer lasers (1991)

Rare-gas–halide excimer lasers are suitable for the production of extremely high peak brightness output in the ultraviolet. The basic properties of these systems are examined and the various techniques employed to produce high power (multiterawatt) operation are described. A specific system using short-pulse injection is examined and its ability to focus to intensities above ∼1019 W cm−2 is discussed. Various applications of such high intensity subpicosecond light sources are also considered.
KINETICS OF METHYLCYCLOHEXANE DEHYDROGENATION OVER PT—Al2O3 (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKINETICS OF METHYLCYCLOHEXANE DEHYDROGENATION OVER PT—Al2O3J. H. Sinfelt, H. Hurwitz, and R. A. ShulmanCite this: J. Phys. Chem. 1960, 64, 10, 1559–1562Publication Date (Print):October 1, 1960Publication History Published online1 May 2002Published inissue 1 October 1960https://pubs.acs.org/doi/10.1021/j100839a054https://doi.org/10.1021/j100839a054research-articleACS PublicationsRequest reuse permissionsArticle Views1670Altmetric-Citations78LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Comparison of a numerical model with measured performance of a seeded, nanosecond KTP optical parametric oscillator (1995)

We have constructed a numerical model of seeded optical parametric oscillators that is appropriate for nanosecond or longer pulsed operation. We have also experimentally characterized the performance of a KTP ring optical parametric oscillator. We present a description of the model and show that its predictions agree well with the observed oscillator performance. We compare spatial beam quality, spectra, efficiency, and full-beam and spatially resolved temporal profiles. Backconversion of signal and idler light to pump is found to affect all the aspects of performance.
BREATHING MECHANICS IN ASTHMA (1966)

Article1 February 1966BREATHING MECHANICS IN ASTHMAMARVIN A. SACKNERMARVIN A. SACKNERSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-2-478 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:I am writing this letter to call your attention to a number of errors and misconceptions reported in an article by LeRoy and Guerrant, entitled "Breathing Mechanics in Asthma," published in the October 1965 issue of the ANNALS OFINTERNALMEDICINE. On p. 579, there is a statement in which the authors quote Marshall as saying that the functional residual capacity (FRC) increases as the lung compliance decreases. The authors then go on to interpret this statement in relation to their own data. Careful reading of Marshall's paper indicates that just the opposite is the case, that... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1966Volume 64, Issue 2Page: 478-479KeywordsAsthmaBreathingLungs Issue Published: 1 February 1966 PDF DownloadLoading ...
Blood management after total joint arthroplasty in the U nited S tates: 19‐year trend analysis (2016)

An increase in the rate of RBC use after TJA and the association between allogeneic blood transfusion and mortality are worrisome. Implementing more effective blood conservation strategies is recommended.
Management of postoperative pain after T6 corpectomy: use of epidural bupivacaine and sufentanil--a case report. (2003)

The objective of this case report is to discuss the successful postoperative analgesic management in a patient who had disseminated rectal cancer pain and failed to obtain pain relief despite high-dose intravenous hydromorphone. A 45-year-old male had metastatic rectal cancer involving multiple vertebrae. After a T6 corpectomy, the patient failed to obtain effective pain relief with massive doses of parenteral opioids. The epidural catheter was placed under fluoroscopy. The patient subsequently failed to obtain relief with epidural administration of bupivacaine and hydromophone. Epidural sufentanil was used to obtain adequate pain control. Postoperative epidural analgesia is a technique worthy of consideration for patients with extreme opioid dependency for corpectomy. Epidural sufentanil can successfully be administered for postoperative pain control for patients receiving a large dose of opioids for cancer pain.
Urban structure analysis of mega city Mexico City using multisensoral remote sensing data (2008)

Mega city Mexico City is ranked the third largest urban agglomeration to date around the globe. The large extension as well as dynamic urban transformation and sprawl processes lead to a lack of up-to-date and area-wide data and information to measure, monitor, and understand the urban situation. This paper focuses on the capabilities of multisensoral remotely sensed data to provide a broad range of products derived from one scientific field - remote sensing - to support urban managing and planning. Therefore optical data sets from the Landsat and Quickbird sensors as well as radar data from the Shuttle Radar Topography Mission (SRTM) and the TerraSAR-X sensor are utilised. Using the multi-sensoral data sets the analysis are scale-dependent. On the one hand change detection on city level utilising the derived urban footprints enables to monitor and to assess spatiotemporal urban transformation, areal dimension of urban sprawl, its direction, and the built-up density distribution over time. On the other hand, structural characteristics of an urban landscape - the alignment and types of buildings, streets and open spaces - provide insight in the very detailed physical pattern of urban morphology on higher scale. The results show high accuracies of the derived multi-scale products. The multi-scale analysis allows quantifying urban processes and thus leading to an assessment and interpretation of urban trends.
Impact of Terminal Heat Sterilization on the Quality of Peritoneal Dialysis Solutions (1997)

In order to meet the sterility requirements imposed by the various regulatory bodies around the world, peritoneal dialysis solutions are terminally heat-sterilized at an acid pH. There is growing concern that both acid pH and the glucose degradation products formed during terminal heat sterilization adversely affect the quality of the therapy provided to the end-stage renal failure patient on peritoneal dialysis. Acid pH and glucose degradation products are thought to contribute to impaired host defense and hence to increased risk of infection, loss of ultrafiltration, and peritoneal fibrosis. On the other hand, peritoneal dialysis solutions prepared by aseptic processing are devoid of in vitro cytotoxicity and hence are considered more biocompatible than heat-sterilized solutions. With new technologies permitting aseptic processing to achieve sterility assurance levels approaching solutions manufactured by terminal heat sterilization, it is possible to produce solutions that are more biocompatible than heat-sterilized products without increasing the risk of microbial contamination.
Wind energy basics : a guide to home- and community-scale wind energy systems (2009)

The availability of clean, renewable power is without question going to be the defining challenge and goal of the 21st century, and wind will lead the way. Internationally acclaimed wind energy expert Paul Gipe is as soberly critical of past energy mistakes as he is convincingly optimistic about the future. The overwhelming challenge of transforming our world from one of fossil carbon to one of clean power seems daunting at best-and paralyzingly impractical at worst. "Wind Energy Basics" offers a solution. Wind power can realistically not only replace the lion's share of oil-, coal-, and natural gasndash; fired electrical plants in the U.S., but also can add enough extra power capacity to allow for most of the cars in the nation to run on electricity. Gipe explains why such a startlingly straightforward solution is eminently doable and can be accomplished much sooner than previously thought-and will have the capacity to resuscitate small and regional economies. "Wind Energy Basics" offers a how-to for home-based wind applications, with advice on which wind turbines to choose and which to avoid. He guides wind-energy installers through considerations such as renewable investment strategies and gives cautionary tales of wind applications gone wrong. And for the activist, he suggests methods of prodding federal, state, and provincial governments to promote energy independence.
A Notebook Format for the Holistic Design of Embedded Systems (Tool Paper) (2018)

This paper proposes the use of notebooks for the design documentation and tool interaction in the rigorous design of embedded systems. Conventionally, a notebook is a sequence of cells alternating between (textual) code and prose to form a document that is meant to be read from top to bottom, in the spirit of literate programming. We extend the use of notebooks to embedded systems specified by pCharts. The charts are visually edited in cells inline. Other cells can contain statements that generate code and analyze the charts qualitatively and quantitatively; in addition, notebook cells can contain other instructions to build the product from the generated code. This allows a notebook to be replayed to re-analyze the design and re-build the product, like a script, but also allows the notebook to be used for presentations, as for this paper, and for the inspection of the design. The interaction with the notebook is done through a web browser that connects to a local or remote server, thus allowing a computationally intensive analysis to run remotely if needed. The pState notebooks are implemented as an extension to Jupyter. The underlying software architecture is described and the issue of proper placement of transition labels in charts embedded in notebooks is discussed.
The first Moscow international workshop on human-computer interaction (1991)

It is safe to say that no one knew what to expect when approximately 15 non-Soviet and 75 Soviet computer professionals gathered for a week-long workshop at the International Center for Scientific and Technical Information (ICSTI) in Moscow. As it unfolded, the 50 paper presentations and 25 product and prototype demos were overshadowed for many of us by the numerous opportunities for individual and group contact. In the end, all of those polled for this report (including about two-thirds of the non-Soviets) strongly favored planning another workshop and hoped to attend.
Identification de filtres inverses linéaires périodiques pour la déconvolution et la séparation de processus cyclostationnaires (2001)

National audience
Photosystem I-polyaniline/TiO2solid-state solar cells: simple devices for biohybrid solar energy conversion (2015)

Novel biophotovoltaic devices were prepared by electrochemically entrapping Photosystem I in a conductive polyaniline film, grown<italic>in situ</italic>on TiO<sub>2</sub>anodes.
<title>Multilayer Antireflection Coatings (ARCs) : A Versatile Method For Design And Optimisation</title> (1983)

A generalised scheme for designing non-quarter wave higher order multilayer ARC systems is developed. In this scheme, one or more than one layer of the initial single/double/ triple layer system, are considered as Herpin equivalent layer and exact optical thicknesses of the constituent layers are calculated. It is seen that the method can yield broad band ARCs and thickness corrections can be applied under in situ conditions. A four layer ARC system, designed and optimised by this method has reflection losses less than 0.5% over a spectral range of 6.55 - 11.25 micrometres.
A Novel Function of Poly(ADP-ribosyl)ation:  Silencing of RNA Polymerase II-Dependent Transcription (1998)

Poly(ADP-ribosyl) transferase (ADPRT) is a nuclear enzyme that catalyzes the synthesis of ADP-ribose polymers from NAD+ as well as the transfer of these polymers onto acceptor proteins. The predominant acceptor of the poly(ADP-ribose) chains appears to be the enzyme itself. The function of ADPRT is thought to be related to a number of nuclear processes, including DNA repair and transcription. In this study, it was found that polymerase II-dependent transcription in nuclear HeLa extracts was repressed in the presence of NAD+ at concentrations as low as 1 microM. This repression was strictly dependent on the activity of ADPRT and correlated with the auto(ADP-ribosyl)ation of the enzyme. Subsequent degradation of the ADP-ribose polymers by enzymatic activities present in the nuclear extracts restored transcriptional activity. It would appear from these results that poly(ADP-ribosyl)ation represents the key event of the mechanism underlying NAD(+)-dependent silencing of transcription. Importantly, ADPRT- and NAD(+)-dependent silencing was observed only if poly(ADP-ribosyl)ation had taken place before formation of the transcription complex was completed. That is, if the nuclear extract was preincubated for more than 15 min in the presence of template DNA, transcription was rendered entirely insensitive to NAD+. These results suggest that poly(ADP-ribosyl)ation may prevent polymerase II-dependent transcription, but does not interfere with ongoing transcription. Taking into account the known function of ADPRT, this enzyme may facilitate recovery from DNA damage by stimulating DNA repair and silencing transcription.