gebhart/patrepeval huggingface dataset:
The Role of Robust Optimization in Single-Leg Airline Revenue Management (2008)

In this paper, we introduce robust versions of the classical static and dynamic single-leg seat allocation models. These robust models take into account the inaccurate estimates of the underlying probability distributions. As observed by simulation experiments, it turns out that for these robust versions the variability compared to their classical counterparts is considerably reduced with a negligible decrease in average revenue.
Matrix remodeling and endometriosis (2005)

The physiological changes in endometriosis involving multiple steps of matrix remodeling include abnormal tissue growth, invasion, and adhesion formation. Endometriosis-associated abnormal matrix remodeling is affected by several molecular factors including proteolytic enzymes and their inhibitors, which mediate tissue turnover throughout the reproductive tract to maintain the integrity of the endometrium, and ovarian steroids, which normally regulate reconstruction and breakdown of endometrium in the menstrual cycle. In addition, various growth factors, such as platelet-derived growth factor, transform growth factor β, and epidermal growth factor, direct modulation of growth, activation, and chemotaxis which may facilitate endometrial cell adhesion onto the peritoneal mesothelium during the development of endometriosis. Furthermore, cell adhesion molecules are believed to be critically involved in most cellular-level processes including cellular differentiation, motility, and attachment with the extracellular matrix. The present review focuses on the abnormal matrix remodeling process and its possible regulatory mechanism in association with endometriosis development. As a greater understanding of the cause of endometriosis is achieved, better treatment of the disease and its prevention become possible. (Reprod Med Biol 2005; <b>4</b>: 93-99).
Prolongevity effects of olive oil phenolic compounds: C. elegans as a model system (2013)

Trabajo presentado al 4th Spanish Worm Meeting, celebrado en Carmona (Sevilla) del 14 al 15 de marzo de 2013.
Modeling and Simulation, Volume 11: Proceedings of the Annual Pittsburgh Conference, 11th, 1980 (1980)

This conference proceedings contains 261 papers. 151 papers are indexed separately. Topics covered include: reliability modeling; materials management models; medical applications; defense systems; biomedical systems; mathematical processes and modeling; process modeling; aerospace technology; microprocessor applications; facilities design in large scale systems; modeling, simulation and control; hardware and software reliability; computers; control systems; decision making; signal processing; traffic operations and control; power system reliability modeling; design of vehicle systems; electric power systems; solar energy; transportation; energy; environment; urban systems analysis; regional systems analysis; and economics.
Extending enterprise architecture modelling with business goals and requirements (2010)

The methods for enterprise architecture (EA), such as The Open Group Architecture Framework, acknowledge the importance of requirements modelling in the development of EAs. Modelling support is needed to specify, document, communicate and reason about goals and requirements. The current modelling techniques for EA focus on the products, services, processes and applications of an enterprise. In addition, techniques may be provided to describe structured requirements lists and use cases. Little support is available however for modelling the underlying motivation of EAs in terms of stakeholder concerns and the high-level goals that address these concerns. This article describes a language that supports the modelling of this motivation. The definition of the language is based on existing work on high-level goal and requirements modelling and is aligned with an existing standard for enterprise modelling: the ArchiMate language. Furthermore, the article illustrates how EA can benefit from analysis techniques from the requirements engineering domain.
Long‐Term Evaluation of the Behavior of a Polytetrafluoroethylene Microprosthesis in the Rat Iliac Artery Myointimal Regression (1998)

The present study represents a long-term investigation of polytetrafluoroethylene (PTFE) vascular microprostheses implanted in the right common iliac artery of rats, with the aim of evaluating the degree of intimal hyperplasia and the changes produced in the vascular prosthesis. A follow-up study was performed between 3 months and 1 year post-implantation, using immunohistochemical techniques, light, and electron microscopy. Three months after implantation, the PTFE segment appeared sandwiched between two cell layers. A general endothelialization was observed on the luminal surface. The underlying myointima appeared as an irregular lining of decreasing thickness, from the distal anastomosis with the receptor artery to the proximal suture. A large number of white blood cells were found adherent to and infiltrating the endothelium. A neoformed adventitia covered the prosthesis on the external surface. At 4 months post-implantation, a destabilization of the luminal surface was observed induced by white blood cells. A progressive reduction in the thickness of the myointimal layer was also apparent, so that 1 year after implantation, the luminal surface of the PTFE prosthesis was fully lined by a thin cell covering. There is good long-term tolerance to implanted PTFE microprostheses. The white blood cells present in the implant region appeared to play an important role in the long-term regression of intimal hyperplasia.
Hepatocellular Carcinoma Risk Prediction Model for the General Population: The Predictive Power of Transaminases (2012)

Models with transaminase data were best able to predict hepatocellular carcinoma risk even among subjects with unknown or HBV- or HCV-negative infection status.
Frame‐shift variant in the CHRNE gene in a juvenile dog with suspected myasthenia gravis‐like disease (2017)

Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Pulsed excimer (KrF) laser melting of amorphous and crystalline silicon layers (1985)

We have investigated depth of melting as a function of pulse energy density in amorphous and crystalline silicon layers. The melting threshold for KrF laser pulses (λ=0.249 μm, τ=24×10−9 s) in amorphous (7660-Å-thick) and crystalline silicon layers were determined to be 0.16±0.02 and 0.75±0.05 J cm−2, respectively. The formation of fine- and large-polycrystalline regions was clearly identified in the amorphous silicon layers for energy densities below that needed for complete annealing. The role of explosive recrystallization in the formation of the fine polycrystalline region is discussed.
Enhanced Abductor Function in Bilateral Vocal Fold Paralysis with Muscle Stem Cells (2023)

Introduction Patients with bilateral vocal fold paralysis (BVFP) experience airway obstruction because of loss of abductor function of posterior cricoarytenoid (PCA) muscles. We previously reported that implantation of autologous muscle progenitor (stem) cells into thyroarytenoid muscles during reinnervation resulted in improved adductor function. In this study, that same approach was applied to treating PCA muscles in a canine model of BVFP. Design Animal study. Methods Two canines underwent baseline measures of glottal resistance (GR), then complete transection and suture repair of both recurrent laryngeal nerves. Muscle stem cells were isolated from skeletal muscle and cultured. Two months later, GR was measured, and then 10 7 stem cells were implanted into one PCA muscle of each animal. After four more months, GR and glottal opening force (GOF) were measured and the muscles were harvested for histologic study. One control dog underwent the same procedures without stem cell implantation, for comparison. Results GR increased by 21%–25% over baseline at 2 months, but after stem cell implantation, improved to 10%–14% over baseline at 6 months. PCA muscle strength, as determined by GOF, was 61%–65% on control sides (no stem cells), and 78%–83% on treated sides (with stem cells). Histology confirmed survival of stem cells and a 50% higher rate of innervation of motor endplates in the stem cell treated sides. Conclusion Autologous muscle progenitor (stem) cells show promise as a potential new therapy for patients with bilateral vocal fold paralysis. Additional studies are needed to determine the optimal number of cells, timing of implantation, and other variables before launching a clinical trial. Level of Evidence NA (animal study) Laryngoscope , 134:324–328, 2024
Evaluation of bituminous binders miscibility for warm-mix recycling techniques (2017)

In the road industry, the current challenge is to produce at lower manufacture temperatures asphalt mixtures incorporating Reclaimed Asphalts (RA). However, the incorporation of cold RA could lead to a non-remobilization of the RA aged binder by the virgin one. A double coating appears, what leads to a binders non-mixture and poorer mechanical properties of asphalt mixtures. The objectives are to develop methods to understand remobilization mechanisms and precisely how the virgin binder comes into contact and diffuses into the RA binder. The temperature influence was investigated. Results show that contact angle measurements and micro X-ray fluorescence have been successfully adapted to the “bitumen/bitumen” interface and interphase study. The RA temperature governs the remobilization initiation phase and influences the blending zone dimension. Therefore, RA should be heated before their incorporation in order to avoid a non-remobilization and guarantee favorable conditions to obtain homogeneous recycled asphalt mixtures with high mechanical performances.
Archive-Based Pheromone Model for Discovering Regression Rules with Ant Colony Optimization (2018)

In this paper we introduce a new algorithm, called Ant-Miner-Reg <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">MA</sub> to tackle the regression problem using an archive-based pheromone model. Existing regression algorithms handle continuous attribute using a discretisation procedure, either in a preprocessing stage or during rule creation. Using an archive as a pheromone model, inspired by the ACO for Mixed-Variable (ACO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">MV</sub> ), we eliminate the need for a discretisation procedure. We compare the proposed Ant-Miner-Reg <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">MA</sub> against Ant-Miner-Reg, an ACO-based regression algorithm that uses a dynamic discretisation procedure, inspired on M5 algorithm, during rule construction process. Our results show that Ant-Miner-Reg <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">MA</sub> achieved a significant improvement in the relative root mean square error of the models created, overcoming the limitations of the dynamic discretisation procedure.
Prenatal risk assessment of gestational hypertension and preeclampsia using clinical information (2016)

Aim: To assess the risks of developing gestational hypertension (GH) and preeclampsia (PE) during pregnancy based on clinical information.
Liquid chromatography/mass spectrometric analysis of explosives: RDX adduct ions (2003)

In liquid chromatography/mass spectrometry (LC/MS) of 1,3,5-trinitro-1,3,5-triazacyclohexane (RDX), attachment of an anion to the analyte molecule is the major way of producing characteristic ions under electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) conditions. The formation of RDX cluster ions in LC/MS and the origin of the clustering agents have been studied. In order to determine whether the clustering anions originate from self-decomposition of RDX in the source or from impurities in the mobile phase, isotopically labeled RDX ((13)C(3)-RDX and (15)N(6)-RDX) and isotopically labeled glycolic acid, acetic acid, ammonium formate and formaldehyde have been used in order to establish the composition and formation route of RDX adduct ions produced in ESI and APCI sources. The results showed that, in ESI, self-decomposition of RDX plays no role in adduct ion formation; rather, RDX clusters with formate, acetate, hydroxyacetate, and chloride anions present in the mobile phase as impurities at ppm levels. In APCI, part of the RDX molecules decompose yielding NO(2) (-) species which in turn cluster with a second RDX molecule producing abundant [M+NO(2)](-) cluster ions.
Exploring the Effect of Au/Pt Ratio on Glycerol Oxidation in Presence and Absence of a Base (2018)

Bimetallic AuPt nanoparticles with different Au:Pt ratios (molar ratio: 9-1, 8-2, 6-4, 2-8, 1-9) and the corresponding Au and Pt monometallic ones were prepared by sol immobilization and immobilized on commercial TiO2 (P25). The catalytic activity was evaluated in the liquid phase glycerol oxidation in presence and absence of a base (NaOH). It was found that the Au:Pt molar ratio and reaction conditions strongly influence the catalytic performance. In the presence of NaOH, Au-rich catalysts were more active than Pt-rich ones, with the highest activity observed for Au9Pt1/TiO2 (6575 h−1). In absence of a base, a higher content of Pt is needed to produce the most active catalyst (Au6Pt4/TiO2, 301 h−1). In terms of selectivity, in presence of NaOH, Au-rich catalysts showed a high selectivity to C3 products (63–72%) whereas Pt-rich catalysts promote the formation of formic and glycolic acids. The opposite trend was observed in absence of a base with Pt-rich catalysts showing higher selectivity to C3 products (83–88%).
Cyclic and differential pulse voltammetric behavior of reactants confined to the electrode surface (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCyclic and differential pulse voltammetric behavior of reactants confined to the electrode surfaceAlan P. Brown and Fred C. AnsonCite this: Anal. Chem. 1977, 49, 11, 1589–1595Publication Date (Print):September 1, 1977Publication History Published online1 May 2002Published inissue 1 September 1977https://pubs.acs.org/doi/10.1021/ac50019a033https://doi.org/10.1021/ac50019a033research-articleACS PublicationsRequest reuse permissionsArticle Views5032Altmetric-Citations671LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Multi-cloud Platform-as-a-service Model, Functionalities and Approaches (2016)

Platform-as-a-Service (PaaS) is the Cloud area concentrating the major growth in the last years in terms of adoption and market share. At the same time Cloud models are evolving towards Hybrid Clouds through the consideration of service expansion across a diversity of Cloud offerings. So far, the majority of multi-cloud approaches have explored IaaS layer, neglecting the rest of the Cloud stack. This limits enterprises to enjoy the benefits of an agile, automated and adaptable infrastructure though flexibility provided by PaaS multi-cloud. This paper presents and compares results of two research projects addressing PaaS multi-cloud architectures: ASCETiC and SeaClouds.
Overlapping-Gate Ccd Imagers On Gallium Arsenide (1987)

Charge-coupled device (CCD) imagers have been fabricated on gallium arsenide (GaAs) with very closely spaced (&lt;100nm) Schottky-barrier metal electrodes. The short interelectrode spacing was achieved by using anodic oxidation in an ethylene glycol based electrolyte. All the active device regions of the CCD imagers were formed by silicon implantation into semi-insulating GaAs substrates followed by rapid thermal activation. The photodetectors were Schottky barrier diodes formed with thin aluminum metal anodes over silicon-implanted active regions in the semi-insulating substrate. The detectors formed a linear array along one side of the CCD channel and a three-phase transfer electrode structure was used. The imagers have been tested with front side illumination at clocking speeds up to 25 MHz.
The Microbiome in Bronchial Biopsies from Smokers and Ex-Smokers with Stable COPD - A Metatranscriptomic Approach (2022)

Current knowledge about the respiratory microbiome is mainly based on 16S ribosomal RNA gene sequencing. Newer sequencing approaches, such as metatranscriptomics, offer the technical ability to measure the viable microbiome response to environmental conditions such as smoking as well as to explore its functional role by investigating host-microbiome interactions. However, knowledge about its feasibility in respiratory microbiome research, especially in lung biopsies, is still very limited. RNA sequencing was performed in bronchial biopsies from clinically stable smokers (<i>n</i> = 5) and ex-smokers (<i>n</i> = 6) with COPD not using (inhaled) steroids. The <i>Trinity</i> assembler was used to assemble non-human reads in order to allow unbiased taxonomical and microbial transcriptional analyses. Subsequently, host-microbiome interactions were analyzed based on associations with host transcriptomic data. Ultra-low levels of microbial mass (0.009%) were identified in the RNA-seq data. Overall, no differences were identified in microbiome diversity or transcriptional profiles of microbial communities or individual microbes between COPD smokers and ex-smokers in the initial test dataset as well as a larger replication dataset. We identified an upregulated host gene set, related to the simultaneous presence of <i>Bradyrhizobium</i>, <i>Roseomonas</i>, <i>Brevibacterium.</i>spp., which were related to PERK-mediated unfolded protein response (UPR) and expression of the microRNA-155-5p. Our results show that metatranscriptomic profiling in bronchial biopsy samples from stable COPD patients yields ultra-low levels of microbial mass. Further, this study illustrates the potential of using transcriptional profiling of the host and microbiome to gain more insight into their interaction in the airways.
Susceptibility Profile ofCulex quinquefasciatus(Diptera: Culicidae) toBacillus sphaericuson Selection with Rotation and Mixture ofB. sphaericusandB. thuringiensis israelensis (2003)

Several strains of Bacillus sphaericus (Neide) (Bsph), a spore-forming bacterium that produces potent mosquitocidal toxins, have been widely used against mosquito larvae globally. In some locations in the field and in the laboratory, moderate to high levels of resistance in Culex pipiens complex mosquito larvae to Bsph have been reported. Practical strategies for dealing with the resistance problem and more importantly to delay or possibly prevent development of resistance to Bsph in the first place are urgently needed. From published reports, we deduced that Bsph-resistant mosquito larvae are completely susceptible to Bacillus thuringiensis ssp. isreaelensis (Bti) and that there is no appearance of cross-resistance to Bti. On the basis of this information, we hypothesized that Bti offers a good potential for the management of resistance to Bsph, especially when it comes to delaying or preventing emergence of resistance. We conducted laboratory studies to see whether rotation of Bsph and Bti or mixture of both delays or prevents resistance development in Bsph-susceptible California Cx. quinquefasciatus. Development of resistance using Bsph alone increased after F15 and fluctuated slightly on further selections. Rotation of Bsph and Bti resulted in much higher level and rapid emergence of resistance to Bsph. However, selection with mixtures of Bti and Bsph for 36 generations showed no emergence of resistance. On the basis of this information, we believe mixtures have a good potential in delaying or preventing Bsph resistance.
O3‐09‐04: Network‐level analysis of PET metabolic features for detection of Alzheimer's disease (2015)

FDG-PET scans offer a powerful window into the metabolic activity in the brain, enabling the characterization of disrupted metabolic patterns in Alzheimer's disease (AD). Regional decrease in metabolic activity has been shown to be a sensitive signature of dementias [1]. Network-level imaging biomarkers derived from structural MRI exhibit potential for individual diganosis of AD [2,3]. Although regional analysis of metabolic features has been studied extensively, the inter-regional metabolic co-variation has not yet been analyzed and used in designing classifiers for incipient AD. We present here a novel study into the group differences in network properties, as well as demonstrate their predictive utility in the detection of prodromal AD. FDG-PET scans were obtained from ADNI-1 dataset for 55 normal controls (NC) and 89 AD subjects at baseline and for 69 progressive MCI (pMCI) subjects (1 year prior to conversion to AD). Raw PET measures were first corrected for partial volume effect (PVE) and then normalized by the mean uptake value of brainstem [1]. They were co-registered to the corresponding T1-MRI scans, and mean uptake values were summarized in patch-wise averages [2]. Based on patch-wise mean uptake values, a GRADIENT network [3] was constructed when the inter-patch difference is greater than a predefined threshold. Network properties (nodal degree, betweenness-centrality etc) were computed from this graph (denoted as PetNet features) to represent the individual subject. They were fused via multiple kernel learning to build a predictive model. The group differences in PetNet features (Figures 1 and 2) reveal an interesting pattern between NC and AD on a group-level, with changes seen in medial temporal lobar structures and few anterior locations. Using RHsT cross-validation [2], we evaluate the classification performance of PetNet features (Figure 3). This approach resulted in an area under ROC (AUC) of 0.92 in discriminating AD from NC, and AUC of 0.85 in discriminating pMCI from NC, which compare favorably to those from structural GRADIENT features [3]. Group Differences between NC and AD in the nodal degree property of PetNet networks. This reveals lowered nodal-degree in AD as compared to NC, with changes in medial temporal lobar structures as well as some anterior brain locations. Group mean Differences between NC and AD in the betweenness centrality property of PetNet networks. These reveal increased betweenness-centrality pattern in AD in the medial temporal lobar structures. Classification results from MKL classifier based on PetNet features. We present novel network-level features summarizing the covariation of metabolism in the brain derived from FDG-PET images. We demonstrate the diagnostic utility of PetNet features for the early detection of Alzheimer's disease.