gebhart/patrepeval huggingface dataset:
[18F]fluorodeoxyglucose (FDG) in vitro uptake in Hodgkin Lymphoma (2004)

Measurement of FDG uptake by PET is a highly sensitive method when it is used to monitor Hodgkin lymphoma treatment. However, interpretation of the follow-up FDG PET data is sometimes difficult, and there is still the need to reduce the number of false-positive/false-negative interpretations. To elucidate the circumstances influencing the quality of FDG PET in Hodgkin lymphoma, radiotracer uptake was studied in vitro in HDLM-2 cells. For that, the cells were treated with/without etoposide, and FDG uptake was measured at different time points. The obtained data were compared with %living cells as a parameter of cytotoxicity. We found a positive correlation between FDG uptake and %living cells indicating that FDG uptake was dramatically reduced in dead cells. These preliminary results show that FDG is an accurate tumour viability marker, and that the described in vitro model is suitable for the further investigation on improving therapy monitoring with PET in Hodgkin lymphoma.
Phosphatidylserine supplementation significantly improves the number of good ball flights (2011)

<b>Copyright information:</b>Taken from "The effect of phosphatidylserine on golf performance"http://www.jissn.com/content/4/1/23Journal of the International Society of Sports Nutrition 2007;4():23-23.Published online 4 Dec 2007PMCID:PMC2217563.
Comparison of trigeminal lateralization with differing stimulants (2023)

Trigeminal-specific stimulants have been shown to activate different receptors preferentially and this likely accounts for variation in sensory perception. It is unclear whether trigeminal sensitivity is similar across different transient receptor potential (TRP) receptors or if dysfunction of different receptors results in differing patient symptoms. Therefore, a prospective cohort study was conducted, consisting of trigeminal lateralization testing with three different stimulants (eucalyptol, isothiocyanate, acetic acid), olfaction testing with Sniffin' Sticks, and measurement of various patient-reported outcome measures (PROMs). A total of 50 participants were enrolled across the olfactory spectrum. Mean TDI score was 27.1 ± 8.3 (range 7.0-39.5) with 38% normosmic and 62% dysosmic. Mean trigeminal lateralization scores out of 20 in the overall cohort were 16.18 (2.78) for eucalyptol, 14.94 (3.49) for mustard oil, and 15.28 (3.68) for vinegar. Eucalyptol showed a significant correlation with threshold scores of Sniffin' Sticks. A significant correlation was found between acetic acid and various PROMs. None of the lateralization scores of the trigeminal stimulants correlated to each other significantly and there was no correlation to age. The lack of correlation suggests that the measured sensitivity of one type of TRP receptor may not translate to similar sensitivity of the other receptors. Additional investigations with TRPV1 and TRPA1 agonists are needed to corroborate our findings.
Construcción de la escala de reserva cognitiva en población española: estudio piloto (2011)

The scale of cognitive reserve could be considered as a suitable instrument to measure cognitive reserve in Spanish population. Nevertheless, more research is required.
Vapor-liquid equilibrium in binary systems of n-pentane + chlorodifluoromethane or + 1,1-difluoroethane (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVapor-liquid equilibrium in binary systems of n-pentane + chlorodifluoromethane or + 1,1-difluoroethaneEva Fransson, Alain Barreau, and Jean VidalCite this: J. Chem. Eng. Data 1992, 37, 4, 521–525Publication Date (Print):October 1, 1992Publication History Published online1 May 2002Published inissue 1 October 1992https://pubs.acs.org/doi/10.1021/je00008a034https://doi.org/10.1021/je00008a034research-articleACS PublicationsRequest reuse permissionsArticle Views105Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The role and robustness of the Gini coefficient as an unbiased tool for the selection of Gini genes for normalising expression profiling data (2019)

Abstract We recently introduced the Gini coefficient (GC) for assessing the expression variation of a particular gene in a dataset, as a means of selecting improved reference genes over the cohort (‘housekeeping genes’) typically used for normalisation in expression profiling studies. Those genes (transcripts) that we determined to be useable as reference genes differed greatly from previous suggestions based on hypothesis-driven approaches. A limitation of this initial study is that a single (albeit large) dataset was employed for both tissues and cell lines. We here extend this analysis to encompass seven other large datasets. Although their absolute values differ a little, the Gini values and median expression levels of the various genes are well correlated with each other between the various cell line datasets, implying that our original choice of the more ubiquitously expressed low-Gini-coefficient genes was indeed sound. In tissues, the Gini values and median expression levels of genes showed a greater variation, with the GC of genes changing with the number and types of tissues in the data sets. In all data sets, regardless of whether this was derived from tissues or cell lines, we also show that the GC is a robust measure of gene expression stability. Using the GC as a measure of expression stability we illustrate its utility to find tissue- and cell line-optimised housekeeping genes without any prior bias, that again include only a small number of previously reported housekeeping genes. We also independently confirmed this experimentally using RT-qPCR with 40 candidate GC genes in a panel of 10 cell lines. These were termed the Gini Genes. In many cases, the variation in the expression levels of classical reference genes is really quite huge (e.g. 44 fold for GAPDH in one data set), suggesting that the cure (of using them as normalising genes) may in some cases be worse than the disease (of not doing so). We recommend the present data-driven approach for the selection of reference genes by using the easy-to-calculate and robust GC.
Mupirocin to PreventS. aureusInfections (2002)

Infections at surgical sites remain an important cause of illness and death and substantially increase health care costs.1 Prevention is thus important not only for the safety of patients, but also in terms of cost effectiveness. In this issue of the Journal, Perl and colleagues2 report the results of a randomized trial that sought to prevent surgical-site infections due to Staphylococcus aureus. S. aureus is the most frequent cause of surgical-site infections and is more virulent than other frequent causes, such as coagulase-negative staphylococci and enterococci. S. aureus therefore accounts for a large proportion of the morbidity and mortality . . .
Query-Driven Strategy for On-the-Fly Term Spotting in Spontaneous Speech (2010)

International audience
Higher order folding of two different classes of chromatin isolated from chicken erythrocyte nuclei. A light scattering study (1982)

Bulk chromatin fragments were excised from chicken erythrocyte nuclei by digestion with micrococcal nuclease. Fractionation into S chromatin (soluble at physiological ionic strengths) and I chromatin (insoluble at physiological ionic strengths) was achieved by dialysis against buffers containing 0.15 M NaCl. The effects of NaCl concentration on the molecular dimensions of S and I chromatins were determined by dynamic and static light scattering. Series of fragment lengths were obtained by gel filtration of S and I chromatins under ionic conditions which lead to maximal intramolecular compaction. Hydrodynamic radii and radii of gyration were determined for fragment lengths ranging from 8 to 53 nucleosomes. These data are in excellent agreement with calculations for extended helical structures. Close-packed solenoidal or superbead structures are not compatible with these data. Comparisons of molecular dimensions derived from light scattering and electron microscopy indicate that considerable shrinkage of chromatin fragments can occur when common methods of sample preparation are used for microscopy.
Sub-pixel registration method for phase diversity wavefront sensor using spatial light modulator (2010)

The purpose of this paper is to develop sub-pixel registration method for adaptive optics system using phase diversity wavefront sensing with a spatial light modulator (SLM). The SLM which is used for wavefront compensation applies multiple time-series known wavefronts as a priori information to the optical system. By using the SLM for the phase diversity generator, it is possible to select the optimal number and shape of phase diversities for various kinds of natural modes of wavefront aberrations which are represented by the Zernike polynomials. In this case, a misregistration of several diversity images has to be compensated before using phase diversity algorithm. We extracted phase diversity method to estimate not only wavefront aberration but also parallel shift between images simultaneously. The suggested method was validated by numerical simulations, and the high estimation accuracy of the distorted wavefront was demonstrated, and nearly diffraction limited images were acquired by wavefront compensation by preventing noise due to misregistrations.
CCA-Treated Wood Waste Remediation Process Optimization with Successive Recirculation Loops Study (2011)

This study aims to improve a decontamination process developed for chromated copper arsenate (CCA)-treated wood waste. This process included metal extraction from the wood by a sulphuric acid-leaching step, and the treatment of metal-loaded leachate by precipitation with ferric chloride and sodium hydroxide. This study showed that sodium hydroxide can be advantageously replaced by calcium hydroxide to enhance performance (>99% metal precipitation above pH 6.5 with Ca(OH)2 and above pH 7 with NaOH) and lower chemical costs [US$30.8/ton of treated wood (TTW) with Ca(OH)2 instead of US$50.83TTW with NaOH]; however sludge production and sludge disposal cost were higher when using Ca(OH)2 for precipitation. Moreover, this study investigated the possibility of recycling the final process effluent obtained after metallic sludge separation. This effluent was successively reused in the process for the leaching step. Five recycling loops comprised of one leaching step, one precipitation step of the leachate with Ca(OH)2, and three rinsing steps were conducted. Arsenic removal from the wood varied from 96 to 98%, chromium removal from 91 to 93% and copper removal from 95 to 96%. Metal removal stayed relatively stable along the five loops, meaning that process water recycling did not influence metal extraction. Leachate treatment with calcium hydroxide and ferric chloride was efficient and allowed, beside metals precipitation, DOC and sulfate partial removal. This avoided fast accumulation of these compounds in the system.
On Evaluating Embedding Models for Knowledge Base Completion (2018)

Knowledge bases contribute to many web search and mining tasks, yet they are often incomplete. To add missing facts to a given knowledge base, various embedding models have been proposed in the recent literature. Perhaps surprisingly, relatively simple models with limited expressiveness often performed remarkably well under today's most commonly used evaluation protocols. In this paper, we explore whether recent models work well for knowledge base completion and argue that the current evaluation protocols are more suited for question answering rather than knowledge base completion. We show that when focusing on a different prediction task for evaluating knowledge base completion, the performance of current embedding models is unsatisfactory even on datasets previously thought to be too easy. This is especially true when embedding models are compared against a simple rule-based baseline. This work indicates the need for more research into the embedding models and evaluation protocols for knowledge base completion.
Four-Component Reaction of Alkyl Isocyanide, Acetylenic Esters, Phenols and Pyrrole; Synthesis of Dialkyl 2-[(alkylimino)(1H-pyrrol-2-yl)methyl]-3-(aryloxy) Succinate (2015)

A new series of dialkyl 2-[(alkylimino)(1H-pyrrol-2-yl)methyl]-3-(aryloxy)succinate derivatives have been synthesised using alkyl isocyanids, acetylenic esters, phenols with electron-withdrawing groups and pyrrole in CH 2 Cl 2 at ambient temperature.
Materials and process engineering projects for the Sandia National Laboratories/Newly Independent States Industrial Partnering Program. Volume 1 (1995)

In July, 1994, a team of materials specialists from Sandia and U S Industry traveled to Russia and the Ukraine to select and fund projects in materials and process technology in support of the Newly Independent States/Industrial Partnering Program (NIS/IPP). All of the projects are collaborations with scientists and Engineers at NIS Institutes. Each project is scheduled to last one year, and the deliverables are formatted to supply US Industry with information which will enable rational decisions to be made regarding the commercial value of these technologies. This work is an unedited interim compilation of the deliverables received to date.
Synthesis of Radiopharmaceuticals via “In-Loop” 11C-Carbonylation as Exemplified by the Radiolabeling of Inhibitors of Bruton's Tyrosine Kinase (2022)

Positron emission tomography (PET) is an important non-invasive tool to help guide the drug discovery and development process. Positron-emitting-radiolabeled drug candidates represent an important tool for drug hunters to gain insight into a drug's biodistribution and target engagement of exploratory biologic targets of interest. Recently, there have been several drug candidates that incorporate an acryloyl functional group due to their ability to form a covalent bond within the biological target of interest through Michael addition. Methods to incorporate a carbon-11 radionuclide into acrylamide derivatives remain challenging given the reactive nature of this moiety. Herein, we report the improved radiosynthesis of carbon-11-containing acrylamide drug candidates, [<sup>11</sup>C]ibrutinib, [<sup>11</sup>C]tolebrutinib, and [<sup>11</sup>C]evobrutinib, using [<sup>11</sup>C]CO and a novel "in-loop" <sup>11</sup> <i>C</i>-carbonylation reaction. [<sup>11</sup>C]Ibrutinib, [<sup>11</sup>C]tolebrutinib, and [<sup>11</sup>C]evobrutinib were reliably synthesized, generating 2.2-7.1 GBq of these radiopharmaceuticals in radiochemical yields ranging from 3.3 to 12.8% (non-decay corrected; relative to starting [<sup>11</sup>C]CO<sub>2</sub>) and molar activities of 281-500 GBq/μmol (7.5-13.5 Ci/μmol), respectively. This study highlights an improved method for incorporating carbon-11 into acrylamide drug candidates using [<sup>11</sup>C]CO within an HPLC loop suitable for clinical translation using simple modifications of standard automated synthesis modules used for cGMP manufacture of PET radioligands.
DISCRIMINATIVE METHODS FOR NOISE ROBUST SPEECH RECOGNITION: A CHIME CHALLENGE BENCHMARK (2013)

The recently introduced second CHiME challenge is a difficult two-microphone speech recognition task with non-stationary interference. Current approaches in the source-separation community have focused on the front-end problem of estimating the clean signal given the noisy signals. Here we pursue a different approach, focusing on state-of-the-art ASR techniques such as discriminative training and various feature transformations, in addition to simple noise suppression methods based on prior-based binary masking with estimated angle of arrival. In addition, we propose an augmented discriminative feature transformation that can introduce arbitrary features to a discriminative feature transform, an efficient combination method of Discriminative Language Modeling (DLM) and Minimum Bayes Risk (MBR) decoding in an ASR post-processing stage, and preliminarily investigate the effectiveness of deep neural networks for reverberated and noisy speech recognition. Using these techniques we present a benchmark on the middle-vocabulary subtask of CHiME challenge, showing their effectiveness for this task. Promising results were also obtained for the proposed augmented feature transformation and combination of DLM and MBR decoding. A part of the training code has been released as an advanced ASR baseline, using the Kaldi speech recognition toolkit.
Single Exponential Decay for the Luminescence Intensity of Ru(bpy)32+ Complex in Langmuir-Blodgett Films (1993)

Abstract The luminescence decay curves of Ru(bpy)32+ in Langmuir-Blodgett (LB) films were often fitted by multiexponential functions whereas those in homogeneous solutions by a single exponential one. Responsible conditions in the LB film preparation for the luminescence decay kinetics were examined. The single exponential decay was observed when the film was prepared in a clean atmosphere and photooxidation of the LB films was avoided.
Study on control strategy of parallel processing UPS systems (2003)

Compared with conventional two-stage conversion UPS systems, parallel processing UPS systems have several advantages such as compact structure, lower losses and improved power factor. But there is a significant problem of un-damped (or damped slowly) DC transient components of supply currents due to the system structure with only a link reactor between source and load. Based on the analysis of the mechanism of the problem, this paper proposes an improved control method to solve the problem. With compensating the pre-calculated steady state supply currents, rather than the transient ones, the DC transient components of supply currents can be eliminated quickly. Simulation results conducted with PSCAD/EMTDC are given to verify the validity of the method.
The low-lying πσ* state and its role in the intramolecular charge transfer of aminobenzonitriles and aminobenzethyne (2008)

Electronic absorption spectra of the low-lying pipi(*) and pisigma(*) states of several aminobenzonitriles and 4-dimethylaminobenzethyne have been studied by time-resolved transient absorption and time-dependent density functional theory calculation. In acetonitrile, the lifetime of the pisigma(*)-state absorption is very short (picoseconds or subpicosecond) for molecules that exhibit intramolecular charge transfer (ICT), and very long (nanoseconds) for those that do not. Where direct comparison of the temporal characteristics of the pisigma(*)-state and the ICT-state transients could be made, the formation rate of the ICT state is identical to the decay rate of the pisigma(*) state within the experimental uncertainty. These results are consistent with the pisigma(*)-mediated ICT mechanism, L(a) (pipi(*))-->pisigma(*)-->ICT, in which the decay rate of the pisigma(*) state is determined by the rate of the solvent-controlled pisigma(*)-->ICT charge-shift reaction. The pipi(*)-->pisigma(*) state crossing does not occur in 3-dimethylaminobenzonitrile or 2-dimethylaminobenzonitrile, as predicted by the calculation, and 4-aminobenzonitrile and 4-dimethylaminobenzethyne does not exhibit the ICT reaction, consistent with the higher energy of the ICT state relative to the pisigma(*) state.
Design of functionally cooperating systems and application towards self-propulsive mini-generators (2020)

Progress of ‘functionally cooperating systems’ is reviewed with emphasis on self-propulsion including design of material systems for applications in mini-generators based on horizontal/vertical motions, self-assembly, and directed transportation.
Induction of cyclooxygenase-2 in monocyte/macrophage by mucins secreted from colon cancer cells (2003)

Up-regulation of cyclooxygenase-2 (COX-2) and overproduction of prostaglandins have been implicated in the initiation and/or progression of colon cancer. However, it is uncertain in which cells and how COX-2 is induced initially in the tumor microenvironment. We found that a conditioned medium of the colon cancer cell line, LS 180, contained a factor to induce COX-2 in human peripheral blood mononuclear cells. This factor was purified biochemically and revealed to be mucins. A small amount of mucins (approximately 100 ng of protein per ml) could elevate prostaglandin E2 production by monocytes. The mucins induced COX-2 mRNA and protein levels of monocytes in a dose- and time-dependent manner, indicating a COX-2-mediated pathway. We also have examined immunohistochemically the localization of COX-2 protein and mucins in human colorectal cancer tissues. It is noteworthy that COX-2-expressing macrophages were located around the region in which mucins were detectable, suggesting that COX-2 also was induced by mucins in vivo. These results suggest that mucins produced by colon cancer cells play a critical role in the initial induction of COX-2 in the tumor microenvironment.
Bacillus subtilis cloning vectors which originated from Corynebacterium xerosis. (1984)

It has been reported that several drug-resistant plasmids found in staphylococci and streptococci were introduced by transformation into Bacillus subtilis.1 ~A) In a previous paper,5) we reported the discovery of Corynebacterium xerosis strains harboring drug-resistant plasmids. Among these plasmids, plasmid PTPIO of 30.4 megadaltons (Md), codes for resistance to chloramphenicol (CP), erythro-
Marginal likelihoods based on Cox's regression and life model (1973)

Journal Article Marginal likelihoods based on Cox's regression and life model Get access J. D. KALBFLEISCH, J. D. KALBFLEISCH State University of New York at Buffalo Search for other works by this author on: Oxford Academic Google Scholar R. L. PRENTICE R. L. PRENTICE * State University of New York at Buffalo *On leave from the University of Waterloo Canada. Search for other works by this author on: Oxford Academic Google Scholar Biometrika, Volume 60, Issue 2, August 1973, Pages 267–278, https://doi.org/10.1093/biomet/60.2.267 Published: 01 August 1973 Article history Received: 01 September 1972 Revision received: 01 December 1972 Published: 01 August 1973