gebhart/patrepeval huggingface dataset:
A Reg Family Protein Is Overexpressed in Islets From a Patient With New-Onset Type 1 Diabetes and Acts as T-Cell Autoantigen in NOD Mice (2002)

Genes overexpressed in pancreatic islets of patients with new-onset type 1 diabetes are potential candidates for novel disease-related autoantigens. RT-PCR-based subtractive hybridization was used on islets from a patient who died at the onset of type 1 diabetes, and it identified a type 1 diabetes-related cDNA encoding hepatocarcinoma-intestine-pancreas/pancreatic-associated protein (HIP/PAP). This protein belongs to the family of Reg proteins implicated in islet regeneration; its gene contains a putative interleukin-6 (IL-6) response element. Islets from healthy cadaveric human donors released HIP/PAP protein into the culture medium, and this release was enhanced by the addition of IL-6. The expression pattern of mouse homologues of HIP/PAP was determined in pancreata of prediabetic and diabetic NOD mice. Both groups showed positive immunostaining for HIP/PAP in islets and ductal epithelium. To test whether HIP/PAP is a target of islet-directed autoimmunity, we measured splenic T-cell responses against HIP/PAP in NOD mice. Spontaneous proliferation was detected after 4 weeks. Lymphocytes from islet infiltrates and pancreatic lymph nodes from 7- to 10-week-old NOD mice were used to establish an HIP/PAP-specific I-A(g7)-restricted T-cell line, termed WY1, that also responded to mouse islets. WY1 cells homed to islets of NOD-SCID mice and adoptively transferred disease when coinjected with purified CD8(+) cells from diabetic NOD mice. Our conclusion was that differential cloning of Reg from islets of a type 1 diabetic patient and the response of Reg to the cytokine IL-6 suggests that HIP/PAP becomes overexpressed in human diabetic islets because of the local inflammatory response. HIP/PAP acts as a T-cell autoantigen in NOD mice. Therefore, autoimmunity to HIP/PAP might create a vicious cycle, accelerating the immune process leading to diabetes.
In vivo validation of a one-dimensional finite-element method for predicting blood flow in cardiovascular bypass grafts (2003)

Current practice in vascular surgery utilizes only diagnostic and empirical data to plan treatments and does not enable quantitative a priori prediction of the outcomes of interventions. We have previously described a new approach to vascular surgery planning based on solving the governing equations of blood flow in patient-specific models. A one-dimensional finite-element method was used to simulate blood flow in eight porcine thoraco-thoraco aortic bypass models. The predicted flow rate was compared to in vivo data obtained using cine phase-contrast magnet resonance imaging. The mean absolute difference between computed and measured flow distribution in the stenosed aorta was found to be 4.2% with the maximum difference of 10.6% anda minimum difference of 0.4%. Furthermore, the sensitivity of the flow rate and distribution with respect to stenosis and branch losses were quantified.
C12E6 and SDS Surfactants Simulated at the Vacuum−Water Interface (2010)

The effect of surface coverage on the aggregate structure for the nonionic hexaethylene glycol monododecyl ether (C(12)E(6)) and anionic sodium dodecyl sulfate (SDS) surfactants at vacuum-water interface has been studied using molecular dynamics simulations. We report the aggregate morphologies and various structural details of both surfactants as a function of surface coverage. Our results indicate that C(12)E(6) tail groups orient less perpendicularly to the vacuum-water interface compared to SDS ones. Interfacial C(12)E(6) shows a transition from gaslike to liquidlike phases as the surface density increases. However, even at the largest coverage considered, interfacial C(12)E(6) aggregates show more disordered structures compared to SDS ones. Both surfactants exhibit a non-monotonic change in planar mobility as the available surface area per molecule varies. The results are interpreted on the basis of the molecular features of both surfactants, with particular emphasis on the properties of the surfactant heads, which are nonionic, long, and flexible for C(12)E(6), as opposed to ionic, compact, and rigid for SDS.
High temporal-resolution phase-contrast MRI demonstrates impaired left-ventricular diastolic relaxation in mice fed a high-fat high-sucrose diet (2016)

Background More than one-third of U.S. adults are obese, incurring an increased risk of heart failure. Increased body mass index is associated with left-ventricular (LV) diastolic dysfunction, which may be one of the pathophysiological links between obesity and heart failure. Mouse models can elucidate molecular mechanisms that underlie cardiovascular disease. In this study we used high temporal-resolution
Formation of Sindbis Virus Capsid Protein in Mammalian Cell-Free Extracts Programmed with Viral Messenger RNA (1974)

Extracts from Krebs II ascites cells and rabbit reticulocytes effectively synthesize viral proteins with Sindbis viral mRNA isolated from Sindbis-infected BHK cells. The major product is identical to Sindbis capsid protein on the basis of its electrophoretic mobility in sodium dodecyl sulfate-acrylamide gels and two-dimensional tryptic-peptide fingerprints. Various amounts of several additional discrete polypeptides are formed, depending on the components of the cell-free extracts. One of these polypeptides may be a prematurely terminated part of the viral-capsid protein, while another is larger in molecular weight than capsid protein but contains the capsid tryptic peptides. Several of the proteins formed in vitro also are detected in extracts of Sindbis-infected BHK cells labeled with [(35)S]methionine. The three proteins found in Sindbis virions are postulated to originate by proteolytic cleavage from a larger molecular weight polypeptide precursor that is translated from a polycistronic mRNA presumed to contain a single site for initiation of protein synthesis. The two in vitro systems appear to translate this polycistronic viral mRNA to yield specific viral capsid although no evidence was found for post-translational proteolysis. Other mechanisms for production of the capsid protein in the cell-free extracts are considered, and some of these may function in the viral-infected cell where unusually large amounts of viral capsid proteins are frequently detected.
Bosentan for Sarcoidosis-associated Pulmonary Hypertension, Age-adjusted D-Dimer Levels in Pulmonary Embolism, and Mean Arterial Blood Pressure Targets in Septic Shock (2014)

Pulmonary hypertension (PH) is present in a significant number of patients with advanced sarcoidosis, and is associated with increased mortality. Baughman and colleagues (1) performed a double-blind, randomized, placebo-controlled trial to determine whether bosentan is effective in treating sarcoidosis-associated PH. A total of 39 patients with sarcoidosis and pulmonary artery (PA) hypertension were randomized to receive either bosentan or placebo in a 2:1 ratio. Patients were excluded if they had severe exercise limitation (New York Heart Association class IV), severe airway obstruction, or significant heart failure. Right heart catheterization was performed before and after 16 weeks of therapy. Outcomes included the changes in mean PA pressure, 6-minute walk distance (6MWD), dyspnea, and quality of life as assessed by validated questionnaires. In the 30 patients with serial hemodynamic data, mean PA pressure decreased by 4 (66.6) mm Hg in the bosentan group (P , 0.02), and increased by 1 (63.7) mm Hg (P . 0.05) in the placebo group. There was no significant change in 6MWD, dyspnea, or quality of life scores in either group. Themajor limitation of this study is its emphasis on PA pressure. Changes in PA pressure correlate poorly with clinical outcomes. Contemporary studies of PH therapy generally emphasize functional outcomes, such as 6MWD (2). In this study, 6MWD decreased in the bosentan group (223 6 69.5 m; P . 0.05), whereas it increased in the placebo group (176 44.1; P. 0.05). Although not statistically significant, this difference, together with more frequent desaturation in the bosentan group, suggests that bosentan worsened gas exchange in some patients (3). In this study, 18 of 35 patients had fibrosis on chest radiograph, a forced vital capacity of less than 60%, or both. However, even a subgroup analysis of patients with forced vital capacity greater than 50% failed to demonstrate an increased 6MWD. Given the modest PH in this study (mean PA pressure, z35 mm Hg; mean right atrial pressure, 5 mm Hg), it is possible that patients with more severe PH (i.e., out of proportion to their fibrosis) would have experienced an increase in their exercise capacity. Until additional studies are performed, however, patients with sarcoidosis-associated PH should be referred to centers with expertise in PH and monitored closely for response to vasodilator therapy, if it is initiated (3). n
Implementing a people focused SPI programme (2001)

Software Process Improvement (SPI) has become the most popular approach to delivering improvements to the software product. Based on statistical process control, the underlying theme is that by understanding and defining the current state of a company&amp;apos;s software development processes, quality practitioners and managers can sufficiently determine and control areas within the development process to achieve improvements in the product. We support this general approach to SPI. We also believe that the people factors in SPI implementation are vital. We believe that to achieve greater success in software process improvement initiatives, greater attention needs to be paid to the perspectives and attitudes of software practitioners. However, we believe that different groups of practitioners have different experiences and attitudes towards SPI.
Correlation between the Mössbauer and Semiconductor Parameters of Tin Telluride (1989)

Abstract The observed correlation between the 119 Sn Mössbauer isomer shift δ and the hole concentration in tin telluride is explained on the basis of the latest literature data on the peculiarities of the peculiarities of the band structure. It is evaluated that the temperature change from 40 to 400 K should not influence the isomer shift.
L'inoculation des légumineuses en France : un exemple de coopération efficace entre l'INRA de Dijon et les fabricants d'inoculants (2001)

Poster *INRA Dijon, Documentation, 17 rue Sully, BP 86510, 21065 Dijon cedex Diffusion du document : INRA Dijon, Documentation, 17 rue Sully, BP 86510, 21065 Dijon cedex
A New Wheel Design for Reducing Weight (2014)

Reducing weight is one of the most important challenges in the automotive industry. A wheel design which enables to reduce weight from 13.5 kg to 10 kg is presented. This achievement is possible thanks to the use of a wide variety of technical processes. The disc is manufactured by Cobapress TM , a casting/forging process which combines the advantages of a high design freedom, good mechanical properties and the absence of porosities. The alloy used is an A356 aluminum alloy modified with strontium. The rim is made of an AA6082 aluminum alloy which is extruded and flow-formed with a thickness from 3.3 down to 2.2 mm. Finally, the FSW (Friction Stir Welding) allows us to weld the two parts with a cavity to minimize the weight. With this technique the welding of the two different alloys is possible with good mechanical properties, the fracture happens outside of the weld during tensile tests. The final wheels passed bending and radial fatigue tests as well as radial impact tests with success.
Differential Expression of Wnts after Spinal Cord Contusion Injury in Adult Rats (2011)

Our results suggest a role for Wnts in spinal cord homeostasis and injury. We demonstrate that after injury Wnt signalling is activated via the Wnt/β-catenin and possibly other pathways. These findings provide an important foundation to further address the function of individual Wnt proteins in vivo and the pathophysiology of spinal cord injury.
Salient Points for Content-Based Retrieval (2001)

In image retrieval, global features related to color or texture are commonly used to describe the image content. The problem with this approach is that these global features cannot capture all parts of the image having different characteristics. Therefore, local computation of image information is necessary. By using salient points to represent local information, more discriminative features can be computed. We show that extracting color and texture information in the locations given by our salient points provides significantly improved results as compared to global feature approaches. Moreover, our salient points lead to a more complete image representation than using corners. 1
Sound-on-Film Recording for Television Broadcasting<!--<xref ref-type="other" rid="fn1-10.5594_J16507">*</xref>--> (1949)

These Remarks Are Confined for the most part to problems of sound on 16-mm film, since such films are of greatest economic — There are three principal bottlenecks tending to degrade the quality of sound obtained from 16-mm films in television broadcasting.
Extra- and intra-cranial arterial calcifications in adults depicted as incidental findings on cone beam CT images (2014)

Significant calcification frequencies were found within the ICA's course, in CBCT scans. Moreover, an increased incidence of either extra- or intra-cranial presence of these depictions and its relation to age and gender was documented.
[Deep brain stimulation therapy for involuntary movements]. (2001)

During the last decade, it has become clear that deep brain stimulation (DBS) therapy provides a dramatic improvement in the symptoms of movement disorders. We have experienced DBS in 110 patients with various types of involuntary movements, and confirmed the benefits of stimulation of the thalamic nucleus ventralis intermedius (Vim), internal globus pallidus (GPi) and subthalamic nucleus (STN) in these patients. DBS therapy affords the best effect on tremor when the Vim is selected as the stimulation site. DBS therapy is also useful for controlling rigidity when the GPi or STN is stimulated. Improvements of bradykinesia and gait disturbance are often induced by DBS therapy involving the GPi or STN. Dopa-induced dyskinesia can be attenuated effectively by the direct and/or indirect effects of DBS therapy. DBS of the Vim also provides excellent control of post-stroke involuntary movements, including hemiballism and hemichoreoathetosis. Dystonia in young patients is controlled effectively by DBS of GPi. Ablative procedures for control of involuntary movement disorders, such as thalamotomy and pallidotomy, always carry a risk associated with creating additional lesions in an already damaged brain. In contrast, there is not such a risk in DBS therapy. This modality of therapy is an important option in treating involuntary movements.
Effect Of Post Plasma Treatment On Reliability Of ECRCVD SioF Films (1998)

As the dimensions of ULSI devices continue to shrink, the RC delay of long interconnections will limit the device high speed performance. In advance logic devices, the stack of the interlayer dielectrics has increased to five or six layers. One of the most effective ways to reduce the parasitic capacitance is using low dielectric constant materials for the interlayer dielectrics. Resent works have indicated that the incorporation of fluorine atoms in the plasma deposited silicon oxide can reduce the effective dielectric constant below 3.5.
Hepatopedal Flow Restoration in Patients Intolerant of Total Portal Diversion (1983)

This report describes an experience with operative restoration of hepatopedal portal blood flow in five patients intolerant of total splanchnic shunting. Portal flow was reestablished by takedown of the total shunt and construction of a selective, distal splenorenal shunt, or by isolation and arterialization of the hepatic limb of the shunted portal vein. In two patients, shunt revision was undertaken electively for chronic encephalopathy, which had been unresponsive to low-protein diet, intestinal antibiosis and oral lactulose. Eighteen and 48 months after operation, both patients have had no encephalopathy on an unrestricted protein intake, and work actively as homemakers. Needle liver biopsies showed enhanced mitotic activity in the early postoperative period, suggesting hepatocyte regeneration. In three patients, shunt conversion or arterialization was undertaken in desperate circumstances, characterized by liver failure (bilirubin greater than 10 mg/dl, albumin less than 2.5 g/dl, prothrombin time greater than 16 sec), coma, and respirator dependency. Although the patients showed immediate, marked improvement in mentation, all three died of intraabdominal hemorrhage in the first few postoperative days, in spite of maximum blood product support. Two conclusions can be drawn from this limited experience: (1) at a time of election, restoration of hepatopedal portal flow can be accomplished with considerable benefit in patients with side-to-side portacaval or hemodynamically equivalent shunts, and (2) similar procedures in patients with fulminant liver failure are unlikely to succeed.
Powder diffraction in materials science using the KENS cold-neutron source (1997)

Since superconductivity fever spread around the world, neutron powder diffraction has become very popular and been widely used by crystallographers, physicists, chemists, mineralogists, and materials scientists. The purpose of present paper is to show, firstly, important characteristics of time-of-flight TOF powder diffraction using cold-neutron source in the study of materials science, and, secondly, recent studies on the structure and function of batteries at the Neutron Science Laboratory (KENS) in the High Energy Accelerator Research Organization (KEK).
Management of staghorn calculus: single puncture with judicious use of the flexible nephroscope (2008)

A single percutaneous access, whenever feasible, offers reduced morbidity without compromising excellent stone-free rates in the management of staghorn calculi.
Effect of Structure on the Spin Switching and Magnetic Bistability of Solid-State Aryl Dicyanomethyl Monoradicals and Diradicals (2019)

Stable organic radicals with switchable spin states have applications in medicine, biology, and material science. An emerging class of such spin-switchable radicals is based on dicyanomethyl radicals, which are typically thermally and air-stable species that form weakly bonded (closed-shell singlet) dimers at a lower temperature that rupture into electron paramagnetic resonance-active diradicals at a higher temperature. However, thus far, the study of these dicyanomethyl radicals has focused on their solution-phase behavior. An understanding of how chemical structure affects the solid-state spin switching behavior for these radicals is unknown. Here, we examine the solid-state spin crossover behavior of 6 monoradicals and 10 tethered diradicals and demonstrate that these species also undergo spin switching in the solid state. We find that the susceptibility for solid-state spin switching for the intermolecular dimers is weakly correlated to the solution-phase Gibbs free energies of dimerization, but no apparent correlations are seen between the solution-state free energies for the intramolecular dimerization and the solid-state behavior. Furthermore, intramolecular diradical dimers have greatly enhanced temperature-responsive behavior compared to their intermolecular counterparts. Crystalline and amorphous powders of the same radicals feature similar spin switching behavior, but the crystalline materials have slower bond-rupture kinetics at higher temperatures, suggesting that solid-state packing effects are an important kinetic consideration. An interesting feature of these systems is that, upon cooling down to room temperature after heating, some radicals remain trapped in the solids, indicating magnetic bistability, while others partially or fully return to the diamagnetic dimers. This work provides insights into how chemical structure affects spin crossover in the solid state for this new class of air-stable radicals, the knowledge of importance for the construction of dynamically responsive solid-state materials, and organic spin crossover polymers.
Perineural Invasion of Pancreatic Ductal Adenocarcinoma is Associated with Early Recurrence after Neoadjuvant Therapy Followed by Resection (2023)

After NAT and surgical resection of PDAC, disease recurrence was common, with distant metastasis being the most common. PNI was significantly higher in the recurrence group.
A SAVI Solution for WLAN (2018)

This document describes a source address validation solution for WLAN
enabling 802.11i or other security mechanisms. This mechanism snoops
NDP and DHCP packets to bind IP address to MAC address, and relies on
the security of MAC address guaranteed by 802.11i or other mechanisms
to filter IP spoofing packets. It can work in the special situations
described in the charter of SAVI(Source Address Validation
Improvements) workgroup, such as multiple MAC addresses on one
interface. This document describes three different deployment
scenarios, with solutions for migration of binding entries when hosts
move from one access point to another.
Wearable Biometric Performance Measurement System for Combat Sports (2017)

This paper presents the design of a wearable system for measurements of athlete's performance in combat sports. The system provides objective measurements of athletes' shots, posture, and movements, and of the effectiveness of their training. The proposed instrumentation is useful to overcome the limits of traditional training methods, which are characterized by a subjective evaluation of the training effectiveness by a coach. The measuring system consists of a distributed network of three battery-powered wireless-sensing node types, worn by the athletes, and one master node, which is in charge of signal acquisition and processing tasks. The master node elaborates training statistics and visualizes them, either in real time during a combat session, or off-line for posttraining analysis. The wearable measuring system has been tested through real combat training sessions of athletes with different weights, ages, and experiences, both male and female. Different from the state-of-art athletes' biometric measurement machines, which are cumbersome and expensive, the proposed system is designed to ensure a low-cost and wearable implementation and to give easy-to-understand feedbacks during training, particularly to nonprofessional athletes.
Codes and iterative decoding on general graphs (2002)

Until recently, most known decoding procedures for error-correcting codes were based either on algebraically calculating the error pattern or on some sort of tree or trellis search. With the advent of turbo coding, a third decoding principle has finally had its breakthrough: iterative decoding. With respect to Viterbi decoding, a code is most naturally described by means of a trellis diagram. The main thesis of the present paper is that, with respect to iterative decoding, the natural way of describing a code is by means of a Tanner graph, which may be viewed as a generalized trellis. More precisely, it is the "time axis" of a trellis that is generalized to a Tanner graph.
A Hyaluronidase Supercatalyst for the Enzymatic Polymerization to Synthesize Glycosaminoglycans (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Influence of blood glucose on heart rate and cardiac autonomic function. The DESIR study (2010)

Heart rate, but not heart rate variability, was associated with glycaemic status and capillary glucose. After deep breathing, heart rate recovery was altered in patients with known diabetes and was associated with reduced heart rate variability. Being overweight was a major correlate of heart rate variability.