gebhart/patrepeval huggingface dataset:
A total synthesis of racemic and optically active ibogamine. Utilization and mechanism of a new silver ion assisted palladium catalyzed cyclization (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA total synthesis of racemic and optically active ibogamine. Utilization and mechanism of a new silver ion assisted palladium catalyzed cyclizationBarry M. Trost, Stephen A. Godleski, and Jean P. GenetCite this: J. Am. Chem. Soc. 1978, 100, 12, 3930–3931Publication Date (Print):June 1, 1978Publication History Published online1 May 2002Published inissue 1 June 1978https://pubs.acs.org/doi/10.1021/ja00480a047https://doi.org/10.1021/ja00480a047research-articleACS PublicationsRequest reuse permissionsArticle Views3309Altmetric-Citations189LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Экологически чистые технологии анализа нефти и нефтепродуктов на основе методов спектроскопии ЯМР (2008)

Quantitative 1H NMR spectroscopy possibilities for determination stock oil quality are analyzed.
Visceral Leishmaniasis: A Difficult Diagnosis and Unusual Causative Agent (1991)

In a young man who had a prolonged fever of unknown origin, hepatosplenomegaly, and progressive pancytopenia, stained smears, blood-agar cultures of bone marrow, and serologic testing for antileishmanial antibodies were negative. Biopsies from liver and bone marrow were uninformative. Visceral leishmaniasis was diagnosed only after splenectomy, when amastigotes were finally cultured from the spleen. The parasite was shown to be an unusual leishmanial parasite, possessing a mixture of intrinsic biochemical and serologic characteristics displayed independently by Leishmania tropica and Leishmania donovani sensu lato, the latter being the usual cause of visceral leishmaniasis. After splenectomy, parasites were also demonstrated in stained bone marrow aspirate smears. Recovery was uneventful after treatment with antimony for 28 days. Visceral leishmaniasis can be a cause of fever of unknown origin and should be considered in its differential diagnosis in endemic areas.
The SLEEPERgenes: a transposase-derived angiosperm-specific gene family (2012)

We propose the ancestral SLEEPER gene was formed after a process of retro-transposition during the evolution of the first angiosperms. It may have acquired an important function early on, as mutation of two SLEEPER genes in rice, like the daysleeper mutant in A. thaliana gave a developmental phenotype indicative of their importance for normal plant development.
TPX2 levels modulate meiotic spindle size and architecture in Xenopus egg extracts (2014)

The spindle segregates chromosomes in dividing eukaryotic cells, and its assembly pathway and morphology vary across organisms and cell types. We investigated mechanisms underlying differences between meiotic spindles formed in egg extracts of two frog species. Small Xenopus tropicalis spindles resisted inhibition of two factors essential for assembly of the larger Xenopus laevis spindles: RanGTP, which functions in chromatin-driven spindle assembly, and the kinesin-5 motor Eg5, which drives antiparallel microtubule (MT) sliding. This suggested a role for the MT-associated protein TPX2 (targeting factor for Xenopus kinesin-like protein 2), which is regulated by Ran and binds Eg5. Indeed, TPX2 was threefold more abundant in X. tropicalis extracts, and elevated TPX2 levels in X. laevis extracts reduced spindle length and sensitivity to Ran and Eg5 inhibition. Higher TPX2 levels recruited Eg5 to the poles, where MT density increased. We propose that TPX2 levels modulate spindle architecture through Eg5, partitioning MTs between a tiled, antiparallel array that promotes spindle expansion and a cross-linked, parallel architecture that concentrates MTs at spindle poles.
Electrical Characterization of Electronic Materials Using FIB-assisted Nanomanipulators (2012)

Focused Ion Beam (FIB) systems have incorporated versatile nanomanipulators with inherent sophisticated machining capability to characterize the electrical properties of highly miniature components of electronic devices. Carbon fibers were chosen as a model system to test the applicability of nanomanipulators to microscale electronic materials, with special emphasis on the direct current current-voltage characterizations in terms of electrode configuration. The presence of contact resistance affects the electrical characterization. This resistance originates from either i) the so-called "spreading resistance" due to the geometrical constriction near the electrode - material interface or ii) resistive surface layers. An appropriate electrode strategy is proposed herein for the use of FIB-based manipulators.
Revisiting Negative Selection Algorithms (2007)

This paper reviews the progress of negative selection algorithms, an anomaly/change detection approach in Artificial Immune Systems (AIS). Following its initial model, we try to identify the fundamental characteristics of this family of algorithms and summarize their diversities. There exist various elements in this method, including data representation, coverage estimate, affinity measure, and matching rules, which are discussed for different variations. The various negative selection algorithms are categorized by different criteria as well. The relationship and possible combinations with other AIS or other machine learning methods are discussed. Prospective development and applicability of negative selection algorithms and their influence on related areas are then speculated based on the discussion.
Reservoir prediction via SVM pattern recognition (2004)

We present a new classification technique to recognize and predict reservoirs from seismic data using support vector machine (SVM) pattern recognition. As the method is data‐driven it is especially suitable for use with non‐linear multiattributes. The method has good generalization ability for cases where the populations are small. In this paper, we describe the method, point out the difference between SVM and neural network approaches, and apply the method to a 3D seismic dataset for the “YD” oilfield. First, we train the SVM using 3D seismic multiattributes at known well locations with well test results. The resulting SVM structure is used to make predictions away from the wells. It is demonstrated that the method is less subject to overtraining difficulties than are neural networks and can be used to distinguish oil and gas reservoirs.
Solid electrolytes—the beta aluminas (1982)

Electrolytes conduct electricity by the movement of ions, whereas metals conduct by the flow of electrons. Until recently, almost all electrolytes known to have high conductivities were liquids, such as molten salts or aqueous solutions of salts. But research over the last twenty years has uncovered many solid electrolytes—substances that have a high ionic conductivity even though they are insulators to the flow of electrons. Physicists often call these solids “superionic conductors” because a number of the compounds have electrical conductivities comparable with those of liquid electrolytes. (But we will avoid this term to prevent a possible mistaken identification with superconductors.)
Structure of plant bile pigments (1983)

Selective peptide cleavage has provided a general procedure for the study of the structure, including stereochemistry, of plant bile pigments. The information derived from the synthesis and spectral analysis of a series of 2,3-dihydrodioxobilins allows the determination of the trans relative stereochemistry for ring A of the ..beta../sub 1/-phycocyanobilin from C-phycocyanin as well as for ring A of phytochrome. A complete structure proof of the five phycoerythrobilins attached to the ..cap alpha.. and ..beta.. subunits of B-phycoerythrin is described. One of these tetrapyrroles is doubly-peptide linked to a single peptide chain through two thioethers at the C-3' and C-18' positions. The four remaining phycoerythrobilins are singly-linked to the protein through thioethers at the C-3' position and all possess the probable stereochemistry C-2(R), C-3(R), C-3'(R), and C-16(R).
The Familial Mediterranean Fever Gene — Cloned at Last (1997)

Familial Mediterranean fever is an inherited condition prevalent among people of the Near East — Arabs, Turks, Armenians, and Sephardic Jews.1 Transmitted as an autosomal recessive trait, familial Mediterranean fever is characterized by sporadic episodes of acute inflammation of the pleural, peritoneal, and joint spaces and, occasionally, the pericardial space and the tunica vaginalis of the testis. These episodes usually last only a few days, but chronic arthritis develops in a few patients. There may be a painful, localized erysipelas-like rash that fades in a few days. Peritonitis due to familial Mediterranean fever resembles an acute abdomen, but laparotomy shows . . .
Computer-Assisted Corneal Topography in Keratoconus (1989)

Using a computer-assisted video-keratoscope, we determined the topographic findings of 14 eyes of 10 patients with keratoconus. None of these patients had worn contact lenses for at least one year prior to examination and were thus free of contact lens-induced topographical alterations. Two patterns commonly seen included inferior steepening more prominent temporally, and central steepening with a superimposed asymmetric bowtie pattern. When compared with normal eyes three quantitative parameters were significantly different (p less than 0.001): central corneal power, difference in corneal power between fellow eyes in the same patients, and steepening of the inferior cornea compared with the superior cornea. Study of the topography in keratoconus using this technique may prove useful for documenting the pattern of involvement of the anterior corneal surface and providing new insights into the pathogenesis of this condition.
Multispectral demosaicking with novel guide image generation and residual interpolation (2014)

A one-shot multispectral imaging system using a multispectral filter array (MSFA) provides a practical solution for compact, low-cost, and real-time multispectral imaging. However, multispectral demosaicking is a challenging problem because each spectral band is significantly undersampled in the MSFA. In this paper, we propose a novel demosaicking algorithm for the MSFA proposed in [1, 2]. Main contributions of this paper are (i) we utilize multispectral correlations for generating a guide image, which is effectively used for interpolation preserving image structures, and (ii) we effectively use residual interpolation (RI) [3] for generating the guide image and interpolating each spectral band. Experimental results demonstrate that our proposed algorithm significantly outperforms existing state-of-the-art algorithms.
Heteroepitaxy on silicon II (1987)

These proceedings collect papers on silicon epitaxy. Topics include: Molecular beam epitaxy, chemical vapor deposition, annealing, transmission electron microscopy, semiconductor device fabrication, doped materials, gallium arsenide, and gallium phosphides.
Structured Fluids as Microreactors for Flavor Formation by the Maillard Reaction (2000)

Thermal reactions of cysteine/furfural and cysteine/ribose mixtures were studied in model systems to gain more insight into the influence of structured fluids such as L(2) microemulsions and cubic phases on the generation of aroma compounds. Formation of 2-furfurylthiol from cysteine/furfural was particularly efficient in L(2) microemulsions and cubic phases compared to aqueous systems. The reaction led to the formation of two new sulfur compounds, which were identified as 2-(2-furyl)thiazolidine and, tentatively, N-(2-mercaptovinyl)-2-(2-furyl)thiazolidine. Similarly, generation of 2-furfurylthiol and 2-methyl-3-furanthiol from cysteine/ribose mixtures was strongly enhanced in structured fluids. The cubic phase was shown to be even more efficient in flavor generation than the L(2) microemulsion. It was denoted "cubic catalyst" or "cubic selective microreactor". The obtained results are interpreted in terms of a surface and curvature control of the reactions defined by the structural properties of the formed surfactant associates.
Human tears: Normal protein pattern and individual protein determinations in adults (1982)

Proteins in tears are known to be highly heterogeneous. We have tried to take into consideration some of the difficulties encountered in studying tear proteins such as tear collection, the choice of the parameters to be studied, the adequacy of techniques for small sample volumes, etc. Levels of total tear proteins were determined in 101 samples and the electrophoreses were performed. On gel slabs, four major proteins were always found to be present: lactoferrin, lysozyme and two tear specific proteins. Concentrations of some individual proteins, lactoferrin, lysozyme, IgA, IgG and albumin were determined. Comparisons of lactoferrin and lysozyme contents were found to be more reliable when based on total protein rather than on their own concentrations as such.
Data from CD133<sup>+</sup> Tumor Initiating Cells in a Syngenic Murine Model of Pancreatic Cancer Respond to Minnelide (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Pancreatic adenocarcinoma is the fourth leading cause for cancer-related mortality with a survival rate of less than 5%. Late diagnosis and lack of effective chemotherapeutic regimen contribute to these grim survival statistics. Relapse of any tumor is largely attributed to the presence of tumor-initiating cells (TIC) or cancer stem cells (CSC). These cells are considered as hurdles to cancer therapy as no known chemotherapeutic compound is reported to target them. Thus, there is an urgent need to develop a TIC-targeted therapy for pancreatic cancer.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; We isolated CD133&lt;sup&gt;+&lt;/sup&gt; cells from a spontaneous pancreatic ductal adenocarcinoma mouse model and studied both surface expression, molecular markers of pancreatic TICs. We also studied tumor initiation properties by implanting low numbers of CD133&lt;sup&gt;+&lt;/sup&gt; cells in immune competent mice. Effect of Minnelide, a drug currently under phase I clinical trial, was studied on the tumors derived from the CD133&lt;sup&gt;+&lt;/sup&gt; cells.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Our study showed for the first time that CD133&lt;sup&gt;+&lt;/sup&gt; population demonstrated all the molecular markers for pancreatic TIC. These cells initiated tumors in immunocompetent mouse models and showed increased expression of prosurvival and proinvasive proteins compared to the CD133&lt;sup&gt;−&lt;/sup&gt; non-TIC population. Our study further showed that Minnelide was very efficient in downregulating both CD133&lt;sup&gt;−&lt;/sup&gt; and CD133&lt;sup&gt;+&lt;/sup&gt; population in the tumors, resulting in a 60% decrease in tumor volume compared with the untreated ones.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusion:&lt;/b&gt; As Minnelide is currently under phase I clinical trial, its evaluation in reducing tumor burden by decreasing TIC as well as non-TIC population suggests its potential as an effective therapy. &lt;i&gt;Clin Cancer Res; 20(9); 2388–99. ©2014 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Effect of Nested Elements on Avoided Crossing between the Higher-Order Core Modes and the Air-Capillary Modes in Hollow-Core Antiresonant Optical Fibers (2018)

Optimal suppression of higher-order modes (HOMs) in hollow-core antiresonant fibers comprising a single ring of thin-walled capillaries was previously studied, and can be achieved when the condition on the capillary-to-core diameter ratio is satisfied (d/D≈0.68). Here we report on the conditions for maximizing the leakage losses of HOMs in hollow-core nested antiresonant node-less fibers, while preserving low confinement loss for the fundamental mode. Using an analytical model based on coupled capillary waveguides, as well as full-vector finite element modeling, we show that optimal d/D value leading to high leakage losses of HOMs, is strongly correlated to the size of nested capillaries. We also show that extremely high value of degree of HOM suppression (∼1200) at the resonant coupling is almost unchanged on a wide range of nested capillary diameter dNested values. These results therefore suggest the possibility of designing antiresonant fibers with nested elements, which show optimal guiding performances in terms of the HOM loss compared to that of the fundamental mode, for clearly defined paired values of the ratios dNested/d and d/D. These can also tend towards a single-mode behavior only when the dimensionless parameter dNested/d is less than 0.30, with identical wall thicknesses for all of the capillaries.
Building connections between primary care and other specialties for a better patient experience (2019)

The International Journal of Integrated Care (IJIC) is an online, open-access, peer-reviewed scientific journal that publishes original articles in the field of integrated care on a continuous basis.IJIC has an Impact Factor of 5.120 (2020 JCR, received in June 2021)
Liatris Gaertn. ex Schreb. (2010)

https://thekeep.eiu.edu/herbarium_specimens_byname/13872/thumbnail.jpg
Lentiviral Vector-Based Prime/Boost Vaccination against AIDS: Pilot Study Shows Protection against Simian Immunodeficiency Virus SIVmac251 Challenge in Macaques (2009)

AIDS vaccination has a pressing need for more potent vaccination vectors capable of eliciting strong, diversified, and long-lasting cellular immune responses against human immunodeficiency virus (HIV). Lentiviral vectors have demonstrated efficiency not only as gene delivery vehicles for gene therapy applications but also as vaccination tools. This is likely due to their ability to transduce nondividing cells, including dendritic cells, enabling sustained endogenous antigen presentation and thus the induction of high proportions of specific cytotoxic T cells and long-lasting memory T cells. We show in a first proof-of-concept pilot study that a prime/boost vaccination strategy using lentiviral vectors pseudotyped with a glycoprotein G from two non-cross-reactive vesicular stomatitis virus serotypes elicited robust and broad cellular immune responses against the vector-encoded antigen, simian immunodeficiency virus (SIV) GAG, in cynomolgus macaques. Vaccination conferred strong protection against a massive intrarectal challenge with SIVmac251, as evidenced both by the reduction of viremia at the peak of acute infection (a mean of over 2 log(10) fold reduction) and by the full preservation of the CD28(+) CD95(+) memory CD4(+) T cells during the acute phase, a strong correlate of protection against pathogenesis. Although vaccinees continued to display lower viremia than control macaques during the early chronic phase, these differences were not statistically significant by day 50 postchallenge. A not-optimized SIV GAG antigen was chosen to show the strong potential of the lentiviral vector system for vaccination. Given that a stronger protection can be anticipated from a modern HIV-1 antigen design, gene transfer vectors derived from HIV-1 appear as promising candidates for vaccination against HIV-1 infection.
Dynamic fluctuations in a bacterial metabolic network (2023)

The operation of the central metabolism is typically assumed to be deterministic, but dynamics and high connectivity of the metabolic network make it potentially prone to generating fluctuations. However, time-resolved measurements of metabolite levels in individual cells that are required to characterize such fluctuations remained a challenge, particularly in small bacterial cells. Here we use single-cell metabolite measurements based on Förster resonance energy transfer, combined with computer simulations, to explore the real-time dynamics of the metabolic network of Escherichia coli. We observe that steplike exposure of starved E. coli to glycolytic carbon sources elicits large periodic fluctuations in the intracellular concentration of pyruvate in individual cells. These fluctuations are consistent with predicted oscillatory dynamics of E. coli metabolic network, and they are primarily controlled by biochemical reactions around the pyruvate node. Our results further indicate that fluctuations in glycolysis propagate to other cellular processes, possibly leading to temporal heterogeneity of cellular states within a population.
The binding of high molecular weight kininogen to cultured human endothelial cells. (1988)

Binding of 125I-labeled high molecular weight kininogen (high Mr kininogen) to cultured human endothelial cells derived from the umbilical cord was demonstrated. The binding was time-dependent, specific, and saturable and required the presence of zinc ions. Maximal binding of 125I-labeled high Mr kininogen was observed at 50 microM Zn2+. Calcium ions inhibited the Zn2+-dependent binding of 125I-labeled high Mr kininogen to endothelial cells. In the presence of 3 mM CaCl2 the total binding of 125I-labeled high Mr kininogen was significantly decreased, and a concentration of 100 microM Zn2+ was then required for the binding of 125I-labeled high Mr kininogen to the cells. Higher calcium concentrations did not further decrease the binding of 125I-labeled high Mr kininogen. Analysis of the binding data by the LIGAND computer program indicated 3.2 X 10(6) binding sites per cell for high Mr kininogen with an apparent Kd of 35 nM at 50 microM ZnCl2 and 1 mM CaCl2. Binding of high Mr kininogen also occurred at physiological plasma Zn2+ concentrations. Saturation of the high Mr kininogen binding sites at 25 microM ZnCl2 occurred at 80 nM of high Mr kininogen with 2.8 X 10(6) molecules of high Mr kininogen bound per cell. At 10 microM ZnCl2, the high Mr kininogen binding sites appeared to be saturated at 130 nM with 1.6 X 10(6) molecules bound per cell. In addition it was demonstrated that endothelial cells internalize 125I-labeled high Mr kininogen, since 125I-labeled high Mr kininogen was detected in solubilized endothelial cells after the cell-bound 125I-labeled high Mr kininogen had been removed with dextran sulfate.
Systematics of azimuthal asymmetries in heavy ion collisions in the 1 A GeV regime (2011)

Using the large acceptance apparatus FOPI, we study central and semi-central collisions in the reactions (energies in A GeV are given in parentheses): 40Ca+40Ca (0.4, 0.6, 0.8, 1.0, 1.5, 1.93), 58Ni+58Ni (0.15, 0.25, 0.4), 96Ru+96Ru (0.4, 1.0, 1.5), 96Zr+96Zr (0.4, 1.0, 1.5), 129Xe+CsI (0.15, 0.25, 0.4), 197Au+197Au (0.09, 0.12, 0.15, 0.25, 0.4, 0.6, 0.8, 1.0, 1.2, 1.5). The observables include directed and elliptic flow. The data are compared to earlier data where possible and to transport model simulations. A stiff nuclear equation of state is found to be incompatible with the data. Evidence for extra-repulsion of neutrons in compressed asymmetric matter is found.