gebhart/patrepeval huggingface dataset:
cis- and trans-γ-Halo-α,β-epoxy Ketones. Reactions with Aniline (1954)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTcis- and trans-γ-Halo-α,β-epoxy Ketones. Reactions with AnilineHarry H. Wasserman and Joyce B. BrousCite this: J. Am. Chem. Soc. 1954, 76, 22, 5811–5812Publication Date (Print):November 1, 1954Publication History Published online1 May 2002Published inissue 1 November 1954https://pubs.acs.org/doi/10.1021/ja01651a075https://doi.org/10.1021/ja01651a075research-articleACS PublicationsRequest reuse permissionsArticle Views50Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
High sensing potentialities of tetra-tert-butyl-metallophthalocyaninesbased acoustic microsensors for xylenes measurement in air at room temperature (2022)

International audience
Combinative method using multi-components quantitation by single reference standard and HPLC fingerprint for comprehensive evaluation of Rhodiola crenulata H.Ohba (2014)

HPLC-DAD quantitative analysis and chromatographic fingerprint analysis were developed to evaluate the quality of <italic>Rhodiola crenulata</italic> H.Ohba from different origins.
Comparison of an Addictive Potential of μ-Opioid Receptor Agonists with G Protein Bias: Behavioral and Molecular Modeling Studies (2021)

Among different approaches to the search for novel-safer and less addictive-opioid analgesics, biased agonism has received the most attention in recent years. Some μ-opioid receptor agonists with G protein bias, including SR compounds, were proposed to induce diminished side effects. However, in many aspects, behavioral effects of those compounds, as well as the mechanisms underlying differences in their action, remain unexplored. Here, we aimed to evaluate the effects of SR-14968 and SR-17018, highly G protein-biased opioid agonists, on antinociception, motor activity and addiction-like behaviors in C57BL/6J mice. The obtained results showed that the compounds induce strong and dose-dependent antinociception. SR-14968 causes high, and SR-17018 much lower, locomotor activity. Both agonists develop reward-associated behavior and physical dependence. The compounds also cause antinociceptive tolerance, however, developing more slowly when compared to morphine. Interestingly, SR compounds, in particular SR-17018, slow down the development of antinociceptive tolerance to morphine and inhibit some symptoms of morphine withdrawal. Therefore, our results indicate that SR agonists possess rewarding and addictive properties, but can positively modulate some symptoms of morphine dependence. Next, we have compared behavioral effects of SR-compounds and PZM21 and searched for a relationship to the substantial differences in molecular interactions that these compounds form with the µ-opioid receptor.
Acquired von Willebrand syndrome: Diagnostic problems and therapeutic options (2006)

We present a case of acquired von Willebrand syndrome (AVWS) due to a monoclonal gammopathy of undetermined significance. Initially this case was diagnosed as congenital von Willebrand disease (VWD); however, re-examination of the medical history rendered a congenital bleeding disorder unlikely. A normal plasma von Willebrand factor (VWF) propeptide level and a very short half-life of VWF after a test infusion with factor VIII/VWF concentrate confirmed the diagnosis AVWS. Two major surgical procedures were successfully managed using high-dose intravenous immunoglobulin. The differential diagnosis with congenital VWD and the diagnostic and therapeutic approaches of AVWS are discussed. We conclude that the diagnosis of AVWS relies primarily on clinical suspicion and a careful bleeding history. A correct diagnosis is essential for optimal perioperative management and treatment of bleeding episodes.
Impaired neuroplasticity in the prefrontal cortex in depression indexed through paired associative stimulation (2018)

Our findings provide evidence for impaired neuroplasticity in DLPFC in patients with depression compared to healthy subjects. Such findings may ultimately help us understand the pathophysiology of MDD and mechanisms involved in its treatment.
Hole-mask colloidal nanolithography combined with tilted-angle-rotation evaporation: A versatile method for fabrication of low-cost and large-area complex plasmonic nanostructures and metamaterials (2014)

Many nano-optical applications require a suitable nanofabrication technology. Hole-mask colloidal nanolithography has proven to be a low-cost and large-area alternative for the fabrication of complex plasmonic nanostructures as well as metamaterials. In this paper, we describe the fabrication process step by step. We manufacture a variety of different plasmonic structures ranging from simple nano-antennas over complex chiral structures to stacked composite materials for applications such as sensing. Additionally, we give details on the control of the nanostructure lateral density which allows for the multilayer-fabrication of complex nanostructures. In two accompanying movies, the fabrication strategy is explained and details are being demonstrated in the lab. The movies can be found at the website of Beilstein TV.
miRDB: an online resource for microRNA target prediction and functional annotations (2014)

MicroRNAs (miRNAs) are small non-coding RNAs that are extensively involved in many physiological and disease processes. One major challenge in miRNA studies is the identification of genes regulated by miRNAs. To this end, we have developed an online resource, miRDB (http://mirdb.org), for miRNA target prediction and functional annotations. Here, we describe recently updated features of miRDB, including 2.1 million predicted gene targets regulated by 6709 miRNAs. In addition to presenting precompiled prediction data, a new feature is the web server interface that allows submission of user-provided sequences for miRNA target prediction. In this way, users have the flexibility to study any custom miRNAs or target genes of interest. Another major update of miRDB is related to functional miRNA annotations. Although thousands of miRNAs have been identified, many of the reported miRNAs are not likely to play active functional roles or may even have been falsely identified as miRNAs from high-throughput studies. To address this issue, we have performed combined computational analyses and literature mining, and identified 568 and 452 functional miRNAs in humans and mice, respectively. These miRNAs, as well as associated functional annotations, are presented in the FuncMir Collection in miRDB.
CapA, an Autotransporter Protein ofCampylobacter jejuni, Mediates Association with Human Epithelial Cells and Colonization of the Chicken Gut (2006)

Two putative autotransporter proteins, CapA and CapB, were identified in silico from the genome sequence of Campylobacter jejuni NCTC11168. The genes encoding each protein contain homopolymeric tracts, suggestive of phase variation mediated by a slipped-strand mispairing mechanism; in each case the gene sequence contained frameshifts at these positions. The C-terminal two-thirds of the two genes, as well as a portion of the predicted signal peptides, were identical; the remaining N-terminal portions were gene specific. Both genes were cloned and expressed; recombinant polypeptides were purified and used to raise rabbit polyclonal monospecific antisera. Using immunoblotting, expression of the ca.116-kDa CapA protein was demonstrated for in vitro-grown cells of strain NCTC11168, for 4 out of 11 recent human fecal isolates, and for 2 out of 8 sequence-typed strains examined. Expression of CapB was not detected for any of the strains tested. Surface localization of CapA was demonstrated by subcellular fractionation and immunogold electron microscopy. Export of CapA was inhibited by globomycin, reinforcing the bioinformatic prediction that the protein is a lipoprotein. A capA insertion mutant had a significantly reduced capacity for association with and invasion of Caco-2 cells and failed to colonize and persist in chickens, indicating that CapA plays a role in host association and colonization by Campylobacter. In view of this demonstrated role, we propose that CapA stands for Campylobacter adhesion protein A.
An Empirical Analysis of Publicity and Advertising under Quality Uncertainty (2012)

Quality of a prescription drug is uncertain to patients, physicians and even the manufacturer of the drug. Because this uncertainty can deter physicians from prescribing the drug, it is important to investigate how various marketing communication activities help reveal the true quality of its product. In particular, this study investigates publicity and advertising under quality uncertainty. Chapter 1 studies the effect of publicity on consumer demand with a reduced form approach. Chapter 2 structurally investigates the roles of detailing and publicity when the information spill-over is present. Both chapters study the market of anti-cholesterol drugs (statins).&#13;\nChapter 1 investigates the effects of publicity (media coverage) on consumer demand. The main obstacle to measuring the impact of publicity is that data on media coverage are difficult to interpret. To overcome this obstacle, we propose a new way to code information presented in news articles, mapping the information to a multi-dimensional attribute space. We combine our publicity data with data on sales, detailing, medical journal advertising, direct-to-consumer advertising (DTCA) and landmark clinical trial outcomes, and estimate a demand model. Our results suggest that not all forms of publicity are equal.&#13;\nIn chapter 2, we study consumer learning about scientific evidence and its impact on demand for pharmaceutical products by using the Bayesian learning model. Unlike previous literature, our learning model allows consumer’s prior quality perceptions to be correlated across brands. This unique feature of the model allows us to investigate information spill-over effects across brands. The information spill-over allows late entrants to free-ride on first movers’ investment in clinical trials and marketing activities and to gain late mover advantage. In addition to using product level market share data, we supplement them with switching rates and discontinuing rates. The switching rate data are particularly useful for taking the presence of switching costs into consideration, which has been ignored in the literature using product-level data. Our estimated structural model has implications for managers in allocating resources to various types of marketing activities more efficiently and helps forecast returns of clinical trials that are sponsored by pharmaceutical firms.
Benchmarking can add up for healthcare accounting. (1994)

In 1993, a healthcare accounting and finance benchmarking survey of hospital and nonhospital organizations gathered statistics about key common performance areas. A low response did not allow for statistically significant findings, but the survey identified performance measures that can be used in healthcare financial management settings. This article explains the benchmarking process and examines some of the 1993 study's findings.
<title>Fiber optic polymer residue monitor</title> (1998)

Semiconductor processing tools that use a plasma to etch polysilicon or oxides produce residue polymers that build up on the exposed surfaces of the processing chamber. These residues are generally stressed and with time can cause flaking onto wafers resulting in yield loss. Currently, residue buildup is not monitored, and chambers are cleaned at regular intervals resulting in excess downtime for the tool. In addition, knowledge of the residue buildup rate and index of refraction is useful in determining the state of health of the chamber process. The authors have developed a novel optical fiber-based robust sensor that allows measurement of the residue polymer buildup while not affecting the plasma process.
SYNFORM ISSUE 2023/02 (2023)

nists of the first Literature Coverage article, covering the innov ative and diastereoselective synthesis of cis thiiranes via 4πelectrocyclization of thiocarbonyl ylides.The third article -a new Name Reaction Biogra phy authored by David Lewis -takes us back in time to the discovery of aryldiazonium ions and their reactivi ty, through an intriguing perspective linking organic chemistry and… beer!The highly poisonous and struc turally fascinating tetrodotoxin is the subject of the next Literature Coverage article, focussing on the new synthetic approach to the puffer fish toxin developed by the group of D. Trauner (USA), who also happens to be an Editor of SYNFACTS.The fifth and closing article is another interview,
Abstract 4499: Total synthesis of tubulysins: A new chemical reaction leads to analogues with enhanced cytotoxicity. (2013)

Abstract Tubulysins are natural products isolated from myxobacterial species and are mitotic poisons which exceed the cell growth inhibition of any clinically relevant traditional chemotherapeutic. Structurally, tubulysins are linear tetrapeptides comprised of N-methyl pipecolic acid (Mep), isoleucine (Ile), the novel amino acid tubuvaline (Tuv), and the novel tyrosine analogue tubutyrosine (Tut). All isolated tubulysins possess an acid- and base-sensitive N-acyloxymethyl substituent not previously found in nature. This N,O-acetal of formaldehyde is attached as a side chain to the amide N-atom of the Tuv fragment. The isolation of natural tubulysins from culture extracts provides only limited quantities. Recently, we reported a large scale total synthesis of natural tubulysin B. Among the multiple synthetic and stereochemical challenges, the most striking were: a) the incorporation of the labile N,O-diacyl N,O-acetal and b) the regioselective hydrolysis of the C-terminal methyl ester (OMe) in the tripeptide Mep-Ile-Tuv-OMe. Herein, we present a convergent total synthesis of tubulysin analogues incorporating an alkoxymethyl side chain. Such molecular architecture allows for compounds that are more base and esterase inert, thus providing additional metabolic/catabolic stabilization. The key step in our synthetic strategy relies on use of a novel reagent for the efficient conversion of the N-acyloxymethyl substituent to novel side chain groups with concomitant facilitated hydrolysis of the C-terminal methyl ester. Following LiOH-based hydrolysis of the C-terminal ester, the Tut fragment is added resulting in novel tubulysin analogues. This novel process opens the door to tubulysin analogs with improved potency for treating cancer. Citation Format: Iontcho Vlahov, Longwu Qi, Fei You, Spencer Hahn, Hari K. Santhapuram, Kevin Wang, Paul Kleindl, Jeremy Vaughn, Marilynn Vetzel, Joseph Reddy, Christopher Leamon. Total synthesis of tubulysins: A new chemical reaction leads to analogues with enhanced cytotoxicity. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4499. doi:10.1158/1538-7445.AM2013-4499
Web Privacy with P3p (2002)

Foreword Preface Part I. Privacy and P3P 1. Introduction to P3P How P3P Works P3P-Enabling a Web Site Why Web Sites Adopt P3P 2. The Online Privacy Landscape Online Privacy Concerns Fair Information Practice Principles Privacy Laws Privacy Seals Chief Privacy Officers Privacy-Related Organizations 3. Privacy Technology Encryption Tools Anonymity and Pseudonymity Tools Filters Identity-Management Tools Other Tools 4. P3P History The Origin of the Idea The Internet Privacy Working Group W3C Launches the P3P Project The Evolving P3P Specification The Patent Issue Feedback from Europe Finishing the Specification Legal Implications Criticism Part II. P3P-Enabling Your Web Site 5. Overview and Options P3P-Enabled Web Site Components P3P Deployment Steps Creating a Privacy Policy Analyzing the Use of Cookies and Third-Party Content One Policy or Many? Generating a P3P Policy and Policy Reference File Helping User Agents Find Your Policy Reference File Combination Files Compact Policies The Safe Zone Testing Your Web Site 6. P3P Policy Syntax XML Syntax General Assertions Data-Specific Assertions The P3P Extension Mechanism The Policy File 7. Creating P3P Policies Gathering Information About Your Site's Data Practices Turning the Information You Gathered into a P3P Policy Writing a Compact Policy Avoiding Common Pitfalls 8. Creating and Referencing Policy Reference Files Creating a Policy Reference File Referencing a Policy Reference File P3P Policies in Policy Reference Files Changing Your P3P Policy or Policy Reference File Avoiding Common Pitfalls 9. Data Schemas Sets, Elements, and Structures Fixed and Variable Categories P3P Base Data Schema Writing a P3P Data Schema 10. P3P-Enabled Web Site Examples Simple Sites Third-Party Agents Third Parties with Their Own Policies Examples From Real Web Sites Part III. P3P Software and Design 11. P3P Vocabulary Design Issues Rating Systems and Vocabularies P3P Vocabulary Terms What's Not in the P3P Vocabulary 12. P3P User Agents and Other Tools P3P User Agents Other Types of P3P Tools P3P Specification Compliance Requirements 13. A P3P Preference Exchange Language (APPEL) APPEL Goals APPEL Evaluator Engines Writing APPEL Rule Sets Processing APPEL Rules Other Privacy Preference Languages 14. User Interface Case Studies Privacy Preference Settings User Agent Behavior Accessibility Privacy Part IV. Appendixes A. P3P Policy and Policy Reference File Syntax Quick Reference B. Configuring Web Servers to Include P3P Headers C. P3P in IE6 D. How to Create a Customized Privacy Import File for IE6 E. P3P Guiding Principles Index
ChemInform Abstract: A SIMPLE PREPARATIVE METHOD FOR OPTICALLY PURE 1‐ALKENYL P‐TOLYL SULFOXIDES VIA 1‐ALKYNYL P‐TOLYL SULFOXIDES (1985)

Abstract Die optisch reinen Alkinylsulfoxide (III), hergestellt aus den Grignard‐Verbindungen (I) und dem Sulfinat (II), werden stereoselektiv in die E‐Alkenylsulfoxide (IV) übergeführt.
Alkyl chain order in a linear polymeric liquid crystal (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAlkyl chain order in a linear polymeric liquid crystalE. T. Samulski, M. M. Gauthier, R. B. Blumstein, and A. BlumsteinCite this: Macromolecules 1984, 17, 3, 479–483Publication Date (Print):March 1, 1984Publication History Published online1 May 2002Published inissue 1 March 1984https://pubs.acs.org/doi/10.1021/ma00133a040https://doi.org/10.1021/ma00133a040research-articleACS PublicationsRequest reuse permissionsArticle Views158Altmetric-Citations59LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Generation of CEP-stable half-cycle 10 µm pulses through two-color laser-induced filamentation (2020)

We have experimentally demonstrated the generation of half-cycle pulses with the center wavelength of 10 µm through two-color filamentation in nitrogen with the duration of 12 fs, which corresponds to 0.36 cycles.
Long-Term Safety and Antiretroviral Activity of Hydroxyurea and Didanosine in HIV-Infected Patients (2000)

Long-term safety, immunologic effects, and antiretroviral activity of hydroxyurea and didanosine were evaluated in this retrospective study. Some 65 HIV-1-infected patients (39 of whom were antiretroviral naive) were studied (mean baseline CD4 count, 362 cells/mm3; mean plasma HIV-1 RNA viral load, 4.8 log10 copies/ml). The mean treatment duration was 20 months. Overall tolerance was good: 15 patients interrupted treatment because of clinical or biologic side effects. Four patients experienced a category B event. Patients had a mean increase of 27 CD4 cell counts after 12 months, of 112 after 24 months and of 59 after 36 months. They had a mean 1. 03 log10 fall in HIV-1 RNA after 12 months, 1.59 log10 after 24 months, and 1.27 log10 after 36 months. After 12 months, 35% developed an HIV-1 RNA viral load <200 copies/ml, 53% after 24 months, and 36% after 36 months. Those whose viral load became undetectable after 12 months have significantly lower baseline RNA values (p =.03). Fourteen patients had a viral load <3.4 log10 copies/ml after 24 months of the double therapy. A prolonged viral load suppression can be achieved using a simple combination of two drugs that are inexpensive and well tolerated.
Evaluation of New bioMérieux Chromogenic CPS Media for Detection of Urinary Tract Pathogens (2015)

Four chromogenic media were compared for their ability to detect urinary tract pathogens in 299 urine specimens, of which 175 were found positive, allowing the growth of 279 microorganisms. After 18 to 24 h of incubation, the CPS ID4, CPSE, CPSO (bioMérieux), and UriSelect4 (Bio-Rad) media showed sensitivities of 97.1%, 99.3%, 99.6%, and 99.6%, respectively.