gebhart/patrepeval huggingface dataset:
Biovision in Textile Wet Processing Industry- Technological Challenges (2011)

Today environmental consciousness is one of the major importance in the textile wet processing industries being concern. Textile industry contributes to one of the major industrial pollution problems facing the country and the pollution causing chemicals such as lime, sodium sulphide, salt, solvents, synthetic pigments etc. are arise mainly from the desizing, scouring, bleaching and dyeing processes of textile wet processing. In order to overcome the hazards caused by the chemical effluents, use of enzymes as a viable alternative has been resorted to in preparatory dyeing operations such as desizing, scouring, and bleaching treatments. This review focuses on the use of microbial enzymes as an alternate technology to the conventional methods, and highlights the importance of these enzymes in minimizing the pollution load. Environmental pollution has been a major irritant to industrial development. Also in this paper we have discussed the advantages and limitations of bio processing techniques in the various textile wet processing such as desizing, scouring, bleaching, bio polishing, bio-singeing and bio-decolouration in the dyeing effluents for cellulosic and non-cellulosic materials.
Estimation of the power electronics lifetime for a wind turbine (2013)

A comparison has been made of the converter lifetime for a 3MW horizontal axis wind turbine for different wind turbulence levels. Torque and speed of the turbine shaft were used to calculate voltage and current time series that those were used to calculate the junction temperatures of diode and IGBT in the generator-side converter by a thermal-electrical model. A rainflow counting algorithm of the junction temperature in combination with an empirical model of the lifetime estimation has been used to calculate the lifetime of the power electronic module in the turbine. The number of parallel converters for each wind condition to achieve 20 years life time also has been found. it is found greater turbulence levels will lead to less lifetime of the converter in the wind turbine.
3D Computational Simulation of Calcium Leaching in Cement Matrices (2014)

Calcium leaching is a degradation process consisting in progressive dissolution of the cement paste by migration of calcium atoms to the aggressive solution. It is therefore, a complex phenomenon involving several phases and dissolution and diffusion processes simultaneously. Along this work, a new computational scheme for the simulation of the degradation process in three dimensions was developed and tested. The toolkit was used to simulate accelerated calcium leaching by a 6M ammonium nitrate solution in cement matrices. The obtained outputs were the three dimensional representation of the matrix and the physicochemical properties of individual phases as a consequence of the degradation process. This not only makes it possible to study the evolution of such properties as a function of time but also as a function of the position within the matrix. The obtained results are in good agreement with experimental values of the elastic modulus in degraded and undegraded samples.
Modulation and coding for linear Gaussian channels (1998)

Shannon's determination of the capacity of the linear Gaussian channel has posed a magnificent challenge to succeeding generations of researchers. This paper surveys how this challenge has been met during the past half century. Orthogonal minimum-bandwidth modulation techniques and channel capacity are discussed. Binary coding techniques for low-signal-to-noise ratio (SNR) channels and nonbinary coding techniques for high-SNR channels are reviewed. Recent developments, which now allow capacity to be approached on any linear Gaussian channel, are surveyed. These new capacity-approaching techniques include turbo coding and decoding, multilevel coding, and combined coding/precoding for intersymbol-interference channels.
A comparison of the interferon gamma assay with the absorbed ELISA for the diagnosis of Johne's disease in cattle (1992)

Two interferon gamma (IFN-gamma) assays, the IFN-gamma enzyme immunoassay (EIA) and the IFN-gamma bioassay and an absorbed ELISA were used to screen 6 cattle herds for Johne's disease. Each herd had a history of Johne's disease but the majority of infected animals did not show clinical signs. The disease status of the cattle, which were removed from the herds, was confirmed by bacteriological culture of faeces or histopathological examination and culture of tissues collected at necropsy. The sensitivities of the IFN-gamma assays and the absorbed ELISA were determined using test results from infected animals. The sensitivity of the IFN-gamma EIA in detecting subclinical (71.8 to 93.3%) and clinical animals (100%) was not significantly different. However, the IFN-gamma bioassay and the absorbed ELISA were more sensitive in detecting cattle with advanced infections (80%) than those that were subclinically affected (16.7 to 33.3%).
Direct generation of optical diffractive elements in perfluorocyclobutane (PFCB) polymers by soft lithography (2000)

Optically diffractive line gratings with 0.58-μm feature sizes have been generated in 100-μm perfluorocyclobutane (PFCB) polymer films by direct micromolding using only a silicon master. Strong reflectivities from the green to red portions of the visible spectrum, depending on incident beam angle, were observed with 3 dB bandwidths of approximately 30 nm. This "negative mold-free" technique permits, for the first time to our knowledge, feature reproduction at submicrometer size scales, eliminates several steps from conventional soft lithographic methods, and marks itself as a practical means for rapidly generating planar photonic structures that operate spectrally in the visible and the near IR telecommunication bands.
1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-[36Cl]chlorouracil; Radiosynthesis and Preliminary Biodistribution Studies in an Experimental Murine Tumor Model (2006)

The nucleoside to nucleic acids pathways are attractive targets for molecular imaging of cell proliferation, for radionuclide-based radiotherapy, for following molecular processes and for drug design, development and delivery. This paper describes the preparation of several radiolabelled nucleosides for comparitive study as markers of tumour cell proliferation. 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-[ 36 Cl]chlorouracil (F[ 36 Cl]ClAU) 1 was synthesized by reaction of 1-(2-deoxy-2-fluoro-arabinofuranosyl)uracil (FAU) with Na 36 Cl in the presence of 2 M HNO 3 (32% radiochemical yield; 13.5 MBq/mmol). 1-(2-Deoxy-2-fluoroarabinofuranosyl)-5-fluoro/bromo/iodouracils radiolabelled with carbon-14 ([2- 14 C]FFAU; 1.5 GBq/mmol), bromine-82 (F[ 82 Br]BrAU; 167 MBq/mmol) and iodine-125 (F[ 125 I]IAU; 10.4 GBq/mmol) were synthesized according to literature methods. These radiolabelled halopyrimidine nucleosides were administered by i.v. injection into BDF 1 mice bearing transplanted Lewis Lung tumors. Uptake of test compounds by target (tumor) tissue was low, and not dissimilar to the reported uptake of their high-specific-activity 5-halopyrimidine nucleoside counterparts. Selected biodistribution data are presented. In general, clearance from blood was rapid, with less that one percent of the injected dose remaining in the blood within 1 h of injection. Tumor uptake was approximately 2% of the injected dose per g of tumor for F[ 36 Cl]ClAU and F[ 125 I]IAU, with [2- 14 C]FFAU showing less that 2% per g and F[ 82 Br]BrAU with over 3% per g at this time after injection. Data are compared to those for the respective high-specific-activity counterparts.
STUDIES DIRECTED TOWARD THE DESIGN OF SPECIFIC DOPAMINE D-1/DA-1 AGONISTS AND ANTAGONISTS (1986)

The central dopamine D-1 receptor is positively coupled to adenylate cyclase. However, the biology of this receptor is still largely unknown. The vascular dopamine DA(,1) receptor is also positively coupled to adenylate cyclase. It is responsible for dilation of several vascular beds. The phenylbenzazepine SKF 38393 and the 4-phenyl-1,2,3,4-tetrahydroisoquinoline, 3',4'-dihydroxynomifensine, were the first selective D-1/DA(,1) agonists. The phenylbenzazepine SCH 23390 was the first selective D-1/DA(,1) antagonist. To further explore the requirements for selective D-1/DA(,1) agonists and antagonists, three classes of compounds were synthesized and evaluated: simple beta-alkyl derivatives of dopamine; 4-phenyl-1,2,3,4-tetrahydroisoquinolines as analogs of 3'-4'-dihydroxynomifensine and SCH 23390; and several cis-hexahydrobenzo a phenanthridines as rigid analogs of 3'-4'-dihydroxynomifensine. From the beta-alkyl dopamine data, it was concluded that 2- (3,4-dihydroxyphenyl)-2-phenethylamine is the dopamine D-1/DA(,1) agonist "pharmacophore". From the 4-phenyl-1,2,3,4-tetrahydro- isoquinoline data, a catechol moiety and a secondary amine group are required for optimum dopamine D-1/DA(,1) activity. The tetra- hydrothieno 2,3c -pyridine analog was the most potent agonist of all compounds tested. For dopamine D-1 antagonist activity, the required "pharmacophore" is N-methyl-2-(3-hydroxyphenyl)-2-phenethylamine. The 10,11-dihydroxy-5,6,6a,7,8,12b-hexahydro- benzo a phenanthridine and the hexahydrothieno a phenanthridine analog had reduced dopamine D-1 agonist properties in comparison to 4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline. Antagonist properties of the 11-hydroxy analog and its N-methyl derivative were comparable to the antagonist properties of the 4-phenyl-1,2,3,4-tetrahydroisoquinolines. There was preliminary evidence presented to indicate that the dopamine D-1 receptor lacks a rotameric preference for the binding of 4-phenyl-1,2,3,4-tetrahydroisoquinolines. Other preliminary evidence suggested a subtle dissimilarity exists between the central dopamine D-1 receptor and the vascular dopamine DA(,1) receptor.
P4‐031: PLATELET APP RATIO IN AD PATIENTS TREATED WITH DONEPEZIL (2014)

The search for peripheral biomarkers of Alzheimer's disease (AD) has become a major focus of research. AD biomarkers are measurable correlates of core pathological markers of the disease, namely those related to intracerebral amyloidosis or its downstream effects within the brain. AD biomarkers can be used for diagnostic purposes, for the prediction of dementia in samples of at-risk individuals, and to monitor biological effects of treatments with antidementia drugs. Platelets are the main source of circulating APP and contain the enzymatic machinery required for its proteolitic metabolism. Studies demonstrated that platelet APP ratio (130/100 kDa sAPP) is altered in patients with AD, reflecting systemic changes in APP metabolism. In the present study, we address the modification of APP ratio in platelets from AD patients treated with donepezil for six months. The aim of this study was compare baseline APP ratio in platelets of patients with AD as compared to healthy controls, and to determine the effect of short- and long-term donepezil treatment on the expression of 130 and 110kDA sAPP peptides. 18 non-medicated older adults with AD were included in this study. The comparison group comprised 37 age-matched, healthy individuals. The expression of APP was determined in platelets of patients and controls at baseline and after 3 and 6 months of donepezil treatment by western blotting using the 22C11 antibody. The 130/110kDa APP ratio was lower in patients compared to healthy controls (p<0.001) at baseline. No differences were observed in APP ratio after donepezil treatment (preliminary analysis). Our findings confirm that platelet APP ratio is reduced in AD, indicating that abnormalities affecting the APP metabolism can be detected in platelets drawn from peripheral blood. Our preliminary findings do not support the modification of this marker as a consequence of donepezil treatment.
Classification of drusen positions in optical coherence tomography data from patients with age-related macular degeneration (2012)

Quantitative analysis of optical coherence tomography volumes is an important tool for both clinicians and researchers. Until now, most work has focused on segmentation of the intraretinal cell layers, but the segmentation of pathological datasets remains challenging. We propose the application of random forest to detect the locations of drusen in the retinal pigment epithelium. This is an important step for further analysis of optical coherence tomography data, for segmentation or otherwise. The presented combination of Bruch's Membrane segmentation with subsequent sampling around the retinal pigment epithelium is a way to quickly compute discriminative features for classification. The proposed method achieves an AUC of 0.94 on our test set, while keeping the computational complexity at a minimum. This makes a clinical setup feasible and provides a tool for clinicians and researchers to quantitatively measure disease progession.
Pattern of invasion of advanced gingivobuccal complex cancer. (2011)

e16000 Background: Squamous cell carcinoma of the gingivobuccal complex (GBC) is the most common oral cancer in India (Pathak et al. Head Neck 2005;27:597-602). Majority of patients with GBC are detected at an advanced stage (Pathak et al. Head Neck 2005;27:597-602). Locoregional recurrence remains the major problem after curative intent treatment (Pathak et al. Head Neck 2005;27:597-602). Advanced GBC tumors involve multiple structures and there is no study in literature that has systemically evaluated GBC tumors for pattern of invasion into various structures and extent of their involvement. Methods: All the patients underwent a standard surgical resection (compartmental resection). Surgically resected specimen was systemically evaluated for all the structures involved, their extent of involvement and their margin status. Detailed clinical history, findings of computed tomography scanning (CT scanning) and findings of pathologic evaluation were compared and results were evaluated. Results: Twenty-six patients with advanced GBC tumors (stage T4) were included in this study. Skin and mandible were involved in 12 cases while pterygoid muscles in 20 cases and masseter muscle in 21 cases. Lymphnodes were involved in ten cases and in six instances only one lymphnode was positive. Imaging missed the diagnosis of Infratemporal fossa (ITF) involvement in 7 cases and recent onset trismus was a better marker to predict ITF involvement. Margins were positive in two cases. Conclusions: Advanced GBC tumors have significant soft tissue extension and involve multiple structures. They are locally aggressive cancers with low lymphnode involvement. Structure Clinical Radiology Pathology Skin 16 13 12 Mandible 18 12 12 Maxilla 8 7 8 Infratemporal fossa 24 13 20 Node 6 6 10
Long-Term Results of Delta Ceramic-on-Ceramic Total Hip Arthroplasty (2022)

At 10-year follow-up, we report excellent results in regard to survivorship, with one patient revised for pain with associated squeaking.
Cognitive Priming and Cognitive Training: Immediate and Far Transfer to Academic Skills in Children (2016)

Cognitive operations are supported by dynamically reconfiguring neural systems that integrate processing components widely distributed throughout the brain. The inter-neuronal connections that constitute these systems are powerfully shaped by environmental input. We evaluated the ability of computer-presented brain training games done in school to harness this neuroplastic potential and improve learning in an overall study sample of 583 second-grade children. Doing a 5-minute brain-training game immediately before math or reading curricular content games increased performance on the curricular content games. Doing three 20-minute brain training sessions per week for four months increased gains on school-administered math and reading achievement tests compared to control classes tested at the same times without intervening brain training. These results provide evidence of cognitive priming with immediate effects on learning, and longer-term brain training with far-transfer or generalized effects on academic achievement.
Improving the Time to Antibiotic Administration in Paediatric Febrile Neutropenia: Implementation of a Clinical Care Pathway in Saudi Arabia (2022)

The aim of this quality improvement practice project was to improve noted delays in the time to antibiotic administration in paediatric febrile neutropenic patients seen at King Faisal Specialist Hospital and Research Centre (KFSH&amp;RC), Saudi Arabia. Larrabee’s 6-step Model for Change of evidence-based practice guided the project. Clinical audit, nursing knowledge survey, comprehensive literature and international clinical guideline review were used to identify and design a clinical care pathway for paediatric febrile neutropenic patients at KFSH&amp;RC. Post-implementation clinical audit showed a reduction in time to antibiotic administration and increased self-efficacy and knowledge among nursing staff in relation to managing the care of febrile neutropenic patients. This reflects similar improvements seen internationally in other centres following the introduction of a clinical pathway. This nursing led practice change was the first of its kind for KFSH&amp;RC. It demonstrated that with support from key stakeholders, Larrabee’s model for evidence- based practice change can be used for introducing a nurse-led clinical care pathway in Saudi Arabia. Highlights •A new clinical care pathway introduced in Saudi Arabia improved time to antibiotic administration in paediatric febrile neutropenic patients. •Implementing a nurse-led clinical care pathway increased nurses’ confidence with managing children with febrile neutropenia and the skills and knowledge related to the accessing and delivering medication via central access devices •With key local stakeholder support evidence-based change frameworks such as that proposed by Larrabee can be used to improve nursing management in Saudi Arabia.
Specific immunostaining for CCP II, a novel calcitonin carboxyl terminal peptide encoded by the calcitonin/CGRP gene. (1993)

Alternative splicing of the primary transcript of the CALC I gene in thyroid C-cells results predominantly in calcitonin (CT) mRNA (exons 1-4), whereas CGRP mRNA (exons 1, 2, 3, 5, and 6) is mainly produced in neuronal cells. The CT mRNA encodes for a protein precursor containing an amino terminal peptide, CT, and a carboxyl terminal peptide (CCP I). CGRP precursor is composed of the same amino terminal peptide and CGRP. Recently we reported the presence of a third mature transcript of the CALC I gene in human medullary thyroid carcinoma (MTC) tissues. This transcript encodes for a precursor containing the amino terminal peptide CT and a novel carboxyl terminal peptide, CCP II. This finding was further confirmed in the TT-cell line derived from a human MTC. We produced monoclonal antibodies against CCP II and developed a rapid and specific immunofluorescence method for this peptide. We demonstrated CCP II-specific immunoreactivity in TT-cells and in MTC tissues. CCP II labeling was relatively homogeneous in contrast to CT and CGRP, which presented striking heterogeneity for intensity of labeling. Therefore, CCP II mRNA is translated in tumor cells in an apparently constitutive way.
PID-Controlled PLL for Fast Frequency-Hopped Systems (2007)

In this work, a novel aided-acquisition technique based on proportional-integral-derivative (PID) control of a phase-locked loop (PLL) is presented. This is achieved by inserting a control block into the PLL during acquisition where originally the output frequency/phase is controlled by a PI controller. This significantly reduces the settling time of the PLL which is important for certain applications such as WLANs where fast frequency-hopped spread-spectrum methods are used. Simulations show that the proposed structure reduces the settling time by 75%.
Distributed multi-robot coverage using micro aerial vehicles (2013)

In this paper we present a solution to the problem of positioning a team of Micro Aerial Vehicles for a surveillance task in an environment of arbitrary and unknown morphology. The problem is addressed taking into account physical and environmental constraints like limited sensor capabilities and obstacle avoidance. The goal is to maximize the area monitored by the team, by identifying the best configuration of the team members. The proposed method is a distributed extension of our previous work based on the Cognitive Adaptive Optimization (CAO) algorithm. This distributed and scalable approach allows us to obtain coordinated and safe trajectories to accomplish the task in 3D environments. The different formulation of the problem considered in this paper allows also dealing with communication constraints. We provide extensive experimental results using data collected by a team of aerial robots and compare the efficiency of the distributed and centralized approach.
3D Reservoir Fluid Flow Simulations Constrained by Seismic Information (1993)

This study aims at linking seismic subsurface images to reservoir fluid flow simulations to enhance reservoir appraisal. Petrophysical characteristics are determined from geology, well logs and laboratory measurements. Reservoir possible limits are inferred from seismic depth&apos; images. Then, the dynamic response of the reservoir is computed using a numerical fluid flow simulator. Matching observed and calculated dynamic responses within this multidisciplinary framework enables a consistent identification of the reservoir limit. It is to demonstrated on a synthetic example that, given a geological model, the well test response is sensitive to modifications of the reservoir boundaries derived from a poststack seismic depth image. This sensitivity is of same order as the sensitivity to the porosity and an order of magnitude less than the sensitivity to the permeability. Preliminary inversion results are also given. The conclusion is that the range of possible reservoir boundaries derived from the seismic image is a valid physical constraint in the reservoir response.
Two forms of VPg on poliovirus RNAs (1981)

The protein (VPg) linked to the 5' termini of poliovirus RNAs resolved into two species when subjected to non-equilibrium electrofocusing. The differently charged forms of VPg were not due to protein phosphorylation nor to variability of the number of phosphate residues associated with the nucleotide moiety remaining after RNase digestion of the nucleoprotein. Single-stranded viral RNA isolated from mature virions contained predominantly the more basic form of VPg, whereas unpackaged single-stranded RNa remaining in cells at the end of the virus replication cycle contained predominantly the more acidic form of VPg. Replicative-form (RF) molecules also contained both species of VPg, with the more acidic form representing the major species. Both plus and minus RNA strands in RF had similar VPg compositions; however, there appeared to be a strongly selective loss of VPg from only the minus strand in RF, particularly at late times postinfection.
Long distance, distributed gas sensing based on micro-nano fiber evanescent wave quartz-enhanced photoacoustic spectroscopy (2017)

A long distance, distributed gas sensing using the micro-nano fiber evanescent wave (FEW) quartz enhanced photoacoustic spectroscopy technique was demonstrated. Such a sensor scheme has the advantages of higher detection sensitivity, distributed gas sensing ability, lower cost, and a simpler fabrication procedure compared to conventional FEW gas sensors using a photonic crystal fiber or a tapered fiber with chemical sputtering. A 3 km single mode fiber with multiple tapers and an erbium doped fiber amplifier with an output optical power of 700 mW were employed to perform long distance, distributed gas measurements.