gebhart/patrepeval huggingface dataset:
Coherent Optical Transmission at 40 and 100 Gbps over 1000 km of DCF-free G.652 and G.655 Fibre Infrastructure (2014)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text O. Zia-Chahabi, D. Grot, T. Guillossou, and E. Pincemin, "Coherent Optical Transmission at 40 and 100 Gbps over 1000 km of DCF-free G.652 and G.655 Fibre Infrastructure," in Optical Fiber Communication Conference, OSA Technical Digest (online) (Optica Publishing Group, 2014), paper W2A.14. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Radiotherapy Synergizes with the Hypoxia-Activated Prodrug Evofosfamide: In Vitro and In Vivo Studies (2017)

Imaging studies identifying the magnitude of hypoxia in tumors indicated that the responsiveness to TH-302 and the antitumor effect of TH-302 were enhanced by combining with XRT in both the TH-302-sensitive SCCVII tumor and -resistant HT29 tumor. Antioxid. Redox Signal. 28, 131-140.
gp130‐linked signal transduction promotes the differentiation and maturation of dendritic cells (2002)

In order to explore the role of gp130-linked signal transduction in the differentiation and maturation of dendritic cells (DC), the mAb, B-S12, an agonist of gp130, was used for the activation of gp130 on DC. The effects of cytokines and of anti-gp130 mAb on the proliferation of DC, and their expression of IL-12 and CD80 (B7-1) by DC were evaluated. DC differentiating from peripheral blood mononuclear cells did not express the IL-6 receptor alpha chain, but expressed gp130. Anti-gp130 mAb promoted the proliferation of DC, induced by IL-4 and granulocyte macrophage colony stimulating factor (GM-CSF), by up-regulating the GM-CSF receptor on DC. DC induced by gp130 mAb and cytokines expressed DC-derived CC chemokine, as measured by RT-PCR. Induced DC also stimulated strong proliferation of autologous T cells in mixed lymphocyte reaction since an up-regulated expression of IL-12 and CD80 (B7-1) was observed in DC activated by anti-gp130 mAb. Thus, gp130 signal transduction is important for the differentiation and maturation of DC.
Next-generation reservoir computing based on memristor array (2022)

As a kind of brain-inspired computing, reservoir computing (RC) has great potential applications in time sequence signal processing and chaotic dynamics system prediction due to its simple structure and few training parameters. Since in the RC randomly initialized network weights are used, it requires abundant data and calculation time for warm-up and parameter optimization. Recent research results show that an RC with linear activation nodes, combined with a feature vector, is mathematically equivalent to a nonlinear vector autoregression (NVAR) machine, which is named next-generation reservoir computing (NGRC). Although the NGRC can effectively alleviate the problems which traditional RC has, it still needs vast computing resources for multiplication operations. In the present work, a hardware implementation method of using computing-in memory paradigm for NGRC is proposed for the first time. We use memristor array to perform the matrix vector multiplication involved in the nonlinear vector autoregressive process for the improvement of the energy efficiency. The Lorenz63 time series prediction task is performed by simulation experiments with the memristor array, demonstrating the feasibility and robustness of this method, and the influence of the weight precision of the memristor devices on the prediction results is discussed. These results provide a promising way of implementing the hardware NGRC.
Substance P Causes Seizures in Neurocysticercosis (2012)

Neurocysticercosis (NCC), a helminth infection of the brain, is a major cause of seizures. The mediators responsible for seizures in NCC are unknown, and their management remains controversial. Substance P (SP) is a neuropeptide produced by neurons, endothelial cells and immunocytes. The current studies examined the hypothesis that SP mediates seizures in NCC. We demonstrated by immunostaining that 5 of 5 brain biopsies from NCC patients contained substance P (SP)-positive (+) cells adjacent to but not distant from degenerating worms; no SP+ cells were detected in uninfected brains. In a rodent model of NCC, seizures were induced after intrahippocampal injection of SP alone or after injection of extracts of cysticercosis granuloma obtained from infected wild type (WT), but not from infected SP precursor-deficient mice. Seizure activity correlated with SP levels within WT granuloma extracts and was prevented by intrahippocampal pre-injection of SP receptor antagonist. Furthermore, extracts of granulomas from WT mice caused seizures when injected into the hippocampus of WT mice, but not when injected into SP receptor (NK1R) deficient mice. These findings indicate that SP causes seizures in NCC, and, suggests that seizures in NCC in humans may be prevented and/or treated with SP-receptor antagonists.
Letter to the Editor. Alternative C-1 screw placement technique (2017)

In their cadaveric study, the authors demonstrated fewer medial breaches with the posterior arch approach than with the Harms technique when a group of spine fellows placed the screws under fluoroscopic guidance. The technique does not require entry into the rich venous plexus surrounding the C-2 ganglion or sacrifice of the ganglion.
A tale of two extremities: A dynamic case of Covid-19 induced hypokalemia and bradycardia leading into Torsade's de pointes (2021)

Although initially thought to be a pulmonary disease but along with time extra-pulmonary manifestations of Covid-19 has demonstrated significant consequences. Electrolyte abnormalities and cardiac dysfunction are examples of such extra-pulmonary pathologies. Therefore, it is important to keep close monitoring for such abnormalities otherwise could lead into life threatening arrythmias.
Combined Effect of Nicotinamide and Streptozotocin on Diabetic Status in Partially Pancreatectomized Adult BALB/c Mice (2000)

Pancreatic regeneration after pancreatectomy has been well documented in the animal models. We have recently reported that STZ diabetic animals operated for partial pancreatectomy showed normoglycemic status after the operation as compared to uncontrolled hyperglycemia and even death in the diabetic sham operated animals. In drug and virus-induced experimental diabetic models there is a high mortality of animals due to uncontrolled destruction of the beta-cells. In order to destroy sufficient beta-cell mass so as to induce diabetes but prevent mortality, we designed present studies to investigate the combined effect of pancreatectomy, nicotinamide, and streptozotocin (STZ) on diabetic status of BALB/c mice. BALB/c mice of either sex were subjected to 50% pancreatectomy. These were then treated with nicotinamide (350 mg/kg body weight) before and after streptozotocin (200 mg/kg body weight) administration. The changes in body weight, blood glucose levels, serum and pancreatic insulin contents of these animals were monitored in experimental and control group for 12 weeks, and follow up studies were made of these animals for further 12 weeks. It was found that there was a drastic loss of body weight, decreased serum and pancreatic insulin levels coupled with sustained and low levels of hyperglycemia in the experimental group as opposed to the control group. The results indicate that partial pancreatectomy followed by nicotinamide and streptozotocin treatment leads to a long-lasting hyperglycemic state, depicting the clinical symptom of NIDDM without mortality. The study probably reveals a new model for experimental diabetes.
Correlates of Hearing Aid Use in UK Adults (2019)

Interventions to promote hearing aid use need to focus on addressing reasons for the perception of hearing difficulties and how to promote hearing aid use. Interventions to promote hearing aid use may need to target demographic groups that are particularly unlikely to use hearing aids, including younger adults, those who live alone and those from ethnic minority backgrounds.
The Active Site Architecture of a Short-Chain Dehydrogenase Defined by Site-Directed Mutagenesis and Structure Modeling (1994)

A high-resolution crystal structure is not currently available for Drosophila alcohol dehydrogenase. A detailed three-dimensional model for this enzyme, based on the structure of 3 alpha,20 beta-hydroxysteroid dehydrogenase, has been generated by extensive computer modeling studies. Aspects of the model concerned with coenzyme binding have been tested by site-directed mutagenesis of residues Gly-14 to Ala, Gly-19 to Ala, Asp-38 to Ala, and Pro-214 to Ser. All enzymes have been characterized in terms of kinetic constants, relative stabilities to guanidinium chloride, and heat inactivation. The contribution of NAD binding to the stabilization of each of the enzymes was also measured. The results obtained with enzymes mutated at positions 14, 38, and 214 are in accordance with published data on Drosophila alcohol dehydrogenase and suggest interactions of these residues with the cofactor NAD. The introduction of a methyl group at residue Gly-19 abolished the ability of the enzyme to utilize NADP instead of NAD. This reflects a proximity of residue Gly-19 to the ribose ring of the bound cofactor. This result, coupled to the three-dimensional model built for Drosophila alcohol dehydrogenase, suggests a binding mechanism for the cofactor NAD different from that found for 3 alpha,20 beta-dehydroxysteroid dehydrogenase and similar to that found in the crystal structure of rat liver dihydropteridine reductase. The model of Drosophila alcohol dehydrogenase also enables many previous observations from chemical modification, sequence comparisons, site-directed mutagenesis, and limited proteolysis experiments to be placed into a structural context. An active site architecture is proposed involving a loop closure mechanism similar to that of lactate dehydrogenase.(ABSTRACT TRUNCATED AT 250 WORDS)
Understanding Interfacial Recombination Processes in Narrow-Band-Gap Organic Solar Cells (2022)

Recombination losses in organic photovoltaics (OPVs) remain a performance-limiting factor, including bulk trap-assisted recombination and interfacial recombination at the electrode:active layer interface. In this work, we demonstrate the role of the front electrode:active layer interface in a narrow-band-gap system, PCE10:COTIC-4F, a promising candidate for semitransparent organic photovoltaics. We systematically address charge generation, recombination, and extraction, with a focus on interfacial recombination via surface traps by a comparison of four device structures with electrodes based on ZnO, ZnO/PFN-Br, PEDOT:PSS, and a self-doped conjugated polyelectrolyte (CPE-K). The amount of interfacial recombination is affected significantly by the electrode choice, while similar levels of bulk recombination are maintained. For the studied blend, we identify ZnO as a suitable choice, pairing low surface recombination rates with beneficial charge carrier generation, favorable energy level alignment, and efficient extraction. In contrast, PEDOT:PSS-based devices suffer from interfacial recombination, which can be suppressed when CPE-K is used instead.
Adhesion of ethylene-acrylic acid copolymers and their blends with paraffin to aluminium (1999)

The adhesion of four ethylene-acrylic acid (EAA) copolymers and of their blends with paraffin to aluminium has been measured by the T-peel test. The peel strength of EAA increased with the square of its acrylic acid content. For each EAA, the addition of paraffin first resulted in an increase of the peel strength up to a maximum when the failure switched from adhesional to cohesive. Two relationships were found between the peel strength of EAA-paraffin blends and the tensile strength of the blends: one valid in the case of adhesional failure and the other in the case of cohesive failure. Both allow very good prediction of the adhesion of EAA-paraffin blends to aluminium.
Performance Measurements of Tertiary Storage Devices (1998)

In spite of the rapid decrease in magnetic disk prices, tertiary storage (i.e., removable media in a robotic storage library) is becoming in-creasingly popular. The fact that so much data can be stored encourages applications that use ever more massive data sets. Appli-cation drivers include multimedia databases, data warehouses, scientific databases, and dig-ital libraries and archives. The database re-search community has responded with investi-gations into systems integration, performance modeling, and performance optimization. Tertiary storage systems present special chal-lenges because of their unusual performance characteristics. Access latencies can range into minutes even on unloaded systems, but transfer rates can be very high. Tertiary storage is implemented with a wide array of technologies, each with its own performance quirks. However, little detailed performance information about tertiary storage devices has been published. In this paper we present de-tailed measurements of several tape drives and robotic storage libraries. The tape drives we measure include the DLT 4000, DLT 7000, Ampex 310, IBM 3590, 4mm DAT, and the Sony DTF drive. This mixture of equipment includes high and low performance drives, ser-pentine and helical scan drives, and cartridge
FDTD and improved PSO methods of coupling for identification and localization of buried objects using GPR B-scan response (2014)

AbstractWe discuss the identification and localization of a buried object using B-scan response of a ground penetration radar (GPR). We use the Finite Difference Time Domain (FDTD) and an Improved Particle Swarm Optimization (IPSO) methods association as an inverse problem. The A-scan response of the soil without the presence of any object is used in this inverse problem to estimate the physical characteristics of this soil. Then, we included these parameters into the inverse problem to characterize a cylindrical buried object from its GPR B-scan response. This response is simulated using the FDTD method. Several simulated cases of cylindrical object were tested with different radius, electrical conductivity, and depth. The proposed method allowed us to locate and identify buried objects (plastic and metal) at different depths.
Determination of flow-regime boundaries for cohesive particles (1991)

The overall objective of this program is the development of a hydrodynamic model to predict the choking/non-choking flow regime boundary of fine, cohesive (that is, Geldart Group C) powders. Specific objectives are to: 1. Develop a two-dimensional hydrodynamic model that can be applied to cohesive solids. 2. Generate large-scale solids-flow data that will be used to verify the model. 3 refs., 33 figs., 1 tab.
Oxygen Evolution Activity and Chemical Stability of Ni and Fe Based Perovskites in Alkaline Media (2018)

The electrochemical activity of LaNiO 3 , La 0.97 NiO 3 , LaNi 0.6 Fe 0.4 O 3 , La 0.97 Ni 0.6 Fe 0.4 O 3 and La 2 Ni 0.9 Fe 0.1 O 4 , toward the oxygen evolution reaction (OER) was measured in 1M KOH at room temperature. All materials showed comparable OER activity with Tafel slopes in the range 56-98 mV/dec. The overvoltage at 10 mA cm -2 , measured on a well-defined geometric surface area, was in the range 0.38-0.45 V. The best performing materials among the ones investigated were LaNiO 3 (multiphase) and La 2 Ni 0.9 Fe 0.1 O 4 . The chemical stability of the stoichiometric materials was also assessed in 31wt% and 45 wt% KOH respectively at 100 C and 220 C. All materials were partially decomposed after 1 week of exposure at 220 C. After 1 week of exposure at 100 C LaNiO 3 had formed secondary phases whereas LaNi 0.6 Fe 0.4 O 3 and La 2 Ni 0.9 Fe 0.1 O 4 showed only traces of secondary phase. The main secondary phases were in all cases La(OH) 3 , NiO, Ni(OH) 2 and Fe 2 O 3 . These observations indicate that the investigated oxygen electrode materials are not suitable for operation in alkaline electrolysis cells above 100 C.
Scalable Synthesis of (R,R)-N,N-Dibenzyl-2-fluorocyclohexan-1-amine with CsF under Hydrogen Bonding Phase-Transfer Catalysis (2021)

Hydrogen bonding phase-transfer catalysis offers a convenient solution to activate safe and economical metal alkali fluorides for enantioselective nucleophilic fluorination. Herein, we demonstrate the scalability of this protocol with the fluorination of 200 g of racemic trans-N,N-dibenzyl-2-bromocyclohexan-1-amine in a mechanically stirred 1 L glass reactor using 0.5 mol % of a bis-urea organocatalyst. In these experiments, full conversions were obtained for high mixing intensities (impeller average shear rate >10 000 s–1; maximum energy dissipation per unit of mass >300 W/kg). The thermal safety of the reaction was assessed by differential scanning calorimetry and reaction calorimetry, assigning the reaction to Stoessel’s critical class 3.
Back Scattering of Explosive Sound by the Deep-Sea Bottom (1962)

The return by the deep-ocean bottom of the sound of an explosive charge consists of an initial burst followed by a long tail representing back-scattered sound at decreasing grazing angles with the bottom. Through analysis of shot records at a number of deep-water locations in the North Atlantic, the back-scattering coefficient of the bottom has been obtained as a function of grazing angle between 30° and 90°. The results indicate that the deep-sea bed behaves as a diffuse or Lambert-law back scatterer at grazing angles from 30° to about 65°; between 65° and 90° (normal incidence), the coefficient rapidly increases, as though specular reflection from normally oriented flat facets of the bottom were occurring. This behavior with angle is similar to that of the sea surface. Analyses in several frequency bands in the range 0.5 to 8.0 kc suggest that the back-scattering coefficient decreases with frequency at a rate of about 2 db per octave.
Efferent Vagal Nerve Stimulation Attenuates Gut Barrier Injury After Burn: Modulation of Intestinal Occludin Expression (2010)

Vagal nerve stimulation performed before injury improves intestinal barrier integrity after severe burn through an efferent signaling pathway and is associated with improved tight junction protein expression.
High Helicobacter pylori eradication rate with a 1‐week regimen containing ranitidine bismuth citrate (1998)

Ranitidine bismuth citrate triple therapy for 1 week (RCM) and dual therapy for 2 weeks (RC) were equally effective for the eradication of H. pylori infection.
Deep Semantic Segmentation Neural Networks of Railway Scene (2018)

It is crucial that the situation of railway scene needs to be periodically monitored to ensure railway safety. Usually, the camera is placed in the driver's cab on a moving vehicle to generate a large number of high-resolution images of railway scene. The traditional image processing inspection methods can only inspect railway scene of the local and simple background. They are feasible sometimes, but not universal and efficient. In this paper, a novel and practical approach is proposed to visual railway scene detection with Deep Semantic Segmentation Convolutional Neural Networks(DSSCNN). It is helpful for precisely locating and detailedly describe important parts of the railway scene in the entire image instead of separately detecting like traditional methods. In addition, three particular blocks named Conv Block, Dilated Conv Block, and Sum Block in DSSCNN are designed to extract more context information from railway images and enhance the segmentation performance. It shows that DSSCNN trained end-to-end and encoder-decoder network structure for semantic segmentation of railway scene are more superior than UNet and Fully Convolutional Networks(FCN) on the same datasets. At the same time, it is also verified that it is feasible and efficient to describe, visual and locate the key parts of the railway scene by DSSCNN.
Characterization of Donor Variability for γδ T Cell ex vivo Expansion and Development of an Allogeneic γδ T Cell Immunotherapy (2020)

Gamma delta (γδ) T cells recently emerged as an attractive candidate for cancer immunotherapy treatments due to their inherent cytotoxicity against both hematological and solid tumors. Moreover, γδ T cells provide a platform for the development of allogeneic cell therapies, as they can recognize antigens independent of MHC recognition and without the requirement for a chimeric antigen receptor. However, γδ T cell adoptive cell therapy depends on <i>ex vivo</i> expansion to manufacture sufficient cell product numbers, which remains challenging and limited by inter-donor variability. In the current study, we characterize the differences in expansion of γδ T cells from various donors that expand (EX) and donors that fail to expand, i.e., non-expanders (NE). Further, we demonstrate that IL-21 can be used to increase the expansion potential of NE. In order to reduce the risk of graft vs. host disease (GVHD) induced by an allogeneic T cell product, αβ T cell depletions must be considered due to the potential for HLA mismatch. Typically, αβ T cell depletions are performed at the end of expansion, prior to infusion. We show that γδ T cell cultures can be successfully αβ depleted on day 6 of expansion, providing a better environment for the γδ T cells to expand, and that the αβ T cell population remains below clinically acceptable standards for T cell-depleted allogeneic stem cell products. Finally, we assess the potential for a mixed donor γδ T cell therapy and characterize the effects of cryopreservation on γδ T cells. Collectively, these studies support the development of an improved allogeneic γδ T cell product and suggest the possibility of using mixed donor γδ T cell immunotherapies.
Reliability modeling for wireless Ultra Wideband biomedical radar sensing network (2010)

Impulse Radio Ultra Wideband technology is a newly emerged technology suitable for low-power, low-complex, and low-cost biomedical radar sensing network. Fault tolerance and reliability, and power-saving perform a critical role in the operation of the IR-UWB human bio-sensing network designed for real-time human body health monitoring. In this paper, an IR-UWB bio-sensing network is proposed and the continuous Markov process is applied to model the proposed UWB bio-sensor network. Two different models are investigated, one is sensor with three transmitting power levels, and the other is sensor with six power levels. Both of them consume same total amount of power. The radar sensor and the sink node Markov model with repair rates taken into account are modeled as well. The paper is a contributing effort to develop an analytical model and explore the trade-offs in wireless IR-UWB bio-sensor network in terms of predicted reliability, operation time (MTTF), and power consumption.