gebhart/patrepeval huggingface dataset:
Synthesis of YAG:Ce Phosphor via Different Aluminum Sources and Precipitation Processes. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
X-ray crystal structure of the streptococcal specific phage lysin PlyC (2012)

Bacteriophages deploy lysins that degrade the bacterial cell wall and facilitate virus egress from the host. When applied exogenously, these enzymes destroy susceptible microbes and, accordingly, have potential as therapeutic agents. The most potent lysin identified to date is PlyC, an enzyme assembled from two components (PlyCA and PlyCB) that is specific for streptococcal species. Here the structure of the PlyC holoenzyme reveals that a single PlyCA moiety is tethered to a ring-shaped assembly of eight PlyCB molecules. Structure-guided mutagenesis reveals that the bacterial cell wall binding is achieved through a cleft on PlyCB. Unexpectedly, our structural data reveal that PlyCA contains a glycoside hydrolase domain in addition to the previously recognized cysteine, histidine-dependent amidohydrolases/peptidases catalytic domain. The presence of eight cell wall-binding domains together with two catalytic domains may explain the extraordinary potency of the PlyC holoenyzme toward target bacteria.
i-vector based speaker recognition on short utterances (2011)

Robust speaker verification on short utterances remains a key consideration when deploying automatic speaker recognition, as many real world applications often have access to only limited duration speech data. This paper explores how the recent technologies focused around total variability modeling behave when training and testing utterance lengths are reduced. Results are presented which provide a comparison of Joint Factor Analysis (JFA) and i-vector based systems including various compensation techniques; Within-Class Covariance Normalization (WCCN), LDA, Scatter Difference Nuisance Attribute Projection (SDNAP) and Gaussian Probabilistic Linear Discriminant Analysis (GPLDA). Speaker verification performance for utterances with as little as 2 sec of data taken from the NIST Speaker Recognition Evaluations are presented to provide a clearer picture of the current performance characteristics of these techniques in short utterance conditions.
Galectins as Regulators of Tumor Growth and Invasion by Targeting Distinct Cell Surface Glycans and Implications for Drug Design (2008)

This chapter contains sections titled: Introduction Galectins: Sensors for more than the Galactose Unit Galectin-1: A Potent Regulator of Cell Growth Compound Libraries and Dendrimers Conclusions References
Hsp90 inhibitor as a sensitizer of cancer cells to different therapies (Review) (2014)

Hsp90 is a molecular chaperone that maintains the structural and functional integrity of various client proteins involved in signaling and many other functions of cancer cells. The natural inhibitors, ansamycins influence the Hsp90 chaperone function by preventing its binding to client proteins and resulting in their proteasomal degradation. Nand C-terminal inhibitors of Hsp90 and their analogues are widely tested as potential anticancer agents in vitro, in vivo as well as in clinical trials. It seems that Hsp90 competitive inhibitors target different tumor types at nanomolar concentrations and might have therapeutic benefit. On the contrary, some Hsp90 inhibitors increased toxicity and resistance of cancer cells induced by heat shock response, and through the interaction of survival signals, that occured as side effects of treatments, could be very effectively limited via combination of therapies. The aim of our review was to collect the data from experimental and clinical trials where Hsp90 inhibitor was combined with other therapies in order to prevent resistance as well as to potentiate the cytotoxic and/or antiproliferative effects.
Swing Leg Moment Cancellation using Coordinated Whole-Body Motion for Humanoids (2003)

蹴り運動のような遊脚運動によって生じるモーメントが大きい場合, ヒューマノイドが安定性を維持することは困難である。本手法は遊脚運動によって生じるモーメントを上半身の運動によるモーメントで相殺することで安定なヒューマノイドの運動を実現する。
RETRACTED: Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells (2011)

The recognition and clearance of dead cells is a process that must occur efficiently to prevent an autoimmune or inflammatory response. Recently, a process was identified wherein the autophagy machinery is recruited to pathogen-containing phagosomes, termed MAPLC3A (LC3)-associated phagocytosis (LAP), which results in optimal degradation of the phagocytosed cargo. Here, we describe the engagement of LAP upon uptake of apoptotic, necrotic, and RIPK3-dependent necrotic cells by macrophages. This process is dependent on some members of the classical autophagy pathway, including Beclin1, ATG5, and ATG7. In contrast, ULK1, despite being required for autophagy, is dispensable for LAP induced by uptake of microbes or dead cells. LAP is required for efficient degradation of the engulfed corpse, and in the absence of LAP, engulfment of dead cells results in increased production of proinflammatory cytokines and decreased production of anti-inflammatory cytokines. LAP is triggered by engagement of the TIM4 receptor by either phosphatidylserine (PtdSer)-displaying dead cells or PtdSer-containing liposomes. Therefore, the consequence of phagocytosis of dead cells is strongly affected by those components of the autophagy pathway involved in LAP.
The interface between biomarker discovery and clinical validation: The tar pit of the protein biomarker pipeline (2008)

The application of "omics" technologies to biological samples generates hundreds to thousands of biomarker candidates; however, a discouragingly small number make it through the pipeline to clinical use. This is in large part due to the incredible mismatch between the large numbers of biomarker candidates and the paucity of reliable assays and methods for validation studies. We desperately need a pipeline that relieves this bottleneck between biomarker discovery and validation. This paper reviews the requirements for technologies to adequately credential biomarker candidates for costly clinical validation and proposes methods and systems to verify biomarker candidates. Models involving pooling of clinical samples, where appropriate, are discussed. We conclude that current proteomic technologies are on the cusp of significantly affecting translation of molecular diagnostics into the clinic.
Can the Need for Colectomy after Computed Tomography-guided Percutaneous Drainage for Diverticular Abscess be Predicted? (2013)

The primary aim of this study was to define predictors of computed tomography (CT)-guided percutaneous abscess drainage treatment failure in complicated diverticulitis. A 10-year retrospective analysis of inpatients seen in surgical consultation for diverticular abscess management subsequently referred for CT-guided percutaneous drainage (PD) was conducted. The clinical courses of patients undergoing a technically successful PD were categorized into three groups: 1) no colectomy; 2) elective colectomy; and 3) nonelective colectomy. Forty study patients were identified. Thirteen (33%) of the 40 patients required a nonelective colectomy, 20 patients (50%) underwent elective resection, and seven patients (18%) have been managed nonoperatively with no recurrent diverticulitis for a median of 46.8 months (range, 3.2 to 84.3 months). Forward logistic regression identified the presence of immunosuppression or renal insufficiency (creatinine 1.5 mg/dL or greater) as factors independently associated with failure of PD and need for nonelective colectomy. No clinical, laboratory, or radiologic variables were predictive of long-term nonoperative success. Although PD allows for the resolution of intra-abdominal sepsis for most cases of diverticulitis complicated by an abscess, a substantial proportion progress to nonelective colectomy, emphasizing the need for clinical vigilance in follow-up.
Leo (1993)

A physically compact, low cost, high performance 3D graphics accelerator is presented. It supports shaded rendering of triangles and antialiased lines into a double-buffered 24-bit true color frame buffer with a 24-bit Z-buffer. Nearly the only chips used besides standard memory parts are 11 ASICs (of four types). Special geometry data reformatting hardware on one ASIC greatly speeds and simplifies the data input pipeline. Floating-point performance is enhanced by another ASIC: a custom graphics microprocessor, with specialized graphics instructions and features. Screen primitive rasterization is carried out in parallel by five drawing ASICs, employing a new partitioning of the back-end rendering task. For typical rendering cases, the only system performance bottleneck is that intrinsically imposed by VRAM.
Modified New Microporous Carbon Layer Structure for Improved PEM Fuel Cell Performance with Low-Pt Catalyst Loadings (2021)

Three types of commercial carbon black with different porosity and hydrophilicity were investigated at various conditions in a new architecture of microporous carbon layers where they are deposited directly on the low loading cathode catalyst layers (0.1 mgPt cm−2) of membrane electrode assemblies (MEAs) used in H2/O2 fuel cells. The benefits of this modified microporous layer (MPL) include reduced interfacial gaps present between the catalyst layer and the conventional MPL-coated gas diffusion layer of the MEAs, reduced water accumulation, and therefore, higher power densities. Acetylene Black and Vulcan XC72R based modified MPLs with mass loadings in the range of 0–1.0 mg cm−2 show improved fuel cell performance in the higher current density regions due to their lower porosity and higher hydrophobicity. The MPL optimum loading under wet and dry conditions is found to be around 0.8 mg cm−2 (∼20 μm), at which a power gain of up to ∼37% is possible as a result of the improved interlayer contact and mass transport under wet conditions as well as enhanced membrane and cathode catalyst layer hydration under dry conditions. Detailed performance characteristics and longer-term studies performed under different humidification levels were also examined and are discussed in this paper.
Efficient Conjugated‐Polymer Optoelectronic Devices Fabricated by Thin‐Film Transfer‐Printing Technique (2008)

Abstract The fabrication of functional multilayered conjugated‐polymer structures with well‐defined organic‐organic interfaces for optoelectronic‐device applications is constrained by the common solubility of many polymers in most organic solvents. Here, we report a simple, low‐cost, large‐area transfer‐printing technique for the deposition and patterning of conjugated‐polymer thin films. This method utilises a planar poly(dimethylsiloxane) (PDMS) stamp, along with a water‐soluble sacrificial layer, to pick up an organic thin film (∼20 nm to 1 µm) from a substrate and subsequently deliver this film to a target substrate. We demonstrate the versatility of this transfer‐printing technique and its applicability to optoelectronic devices by fabricating bilayer structures of poly(9,9‐di‐ n ‐octylfluorene‐ alt ‐(1,4‐phenylene‐((4‐ sec ‐butylphenyl)imino)‐1,4‐phenylene))/poly(9,9‐di‐ n ‐octylfluorene‐ alt ‐benzothiadiazole) (TFB/F8BT) and poly(3‐hexylthiophene)/methanofullerene([6,6]‐phenyl C 61 butyric acid methyl ester) (P3HT/PCBM), and incorporating them into light‐emitting diodes (LEDs) and photovoltaic (PV) cells, respectively. For both types of device, bilayer devices fabricated with this transfer‐printing technique show equal, if not superior, performance to either blend devices or bilayer devices fabricated by other techniques. This indicates well‐controlled organic‐organic interfaces achieved by the transfer‐printing technique. Furthermore, this transfer‐printing technique allows us to study the nature of the excited states and the transport of charge carriers across well‐defined organic interfaces, which are of great importance to organic electronics.
Production of L-tryptophan by auxotrophs derived from analogue-resistant mutants of Escherichia coli (1988)

트립토판 생산성을 향상시키기 위해 대장균 변이 주인 SB1007로부터 sulfanilamide 내성 균주를 유도하여 SA 3-39-16출 분리하고 이 균주로부터 tyrosine 영양요구주인 TY-90을 개발하였다. 시험관배양시 TY-90균주는 모균주보다 트립토판 생산량이 우수하였으나 발효조 배양시에는 모균주에 비해 낮은 양의 트립토판이 축적되었다. 발효조에서의 생산성 증대를 인해 또 다른 대장균 변이주인 SB2756으로부터 새로운 변이주의 개발을 모색하였다. 먼저 이중 영양요구성 균주인 SB2756의 revertant를 분리하여 그중 2,000mg/ $\ell$ 농도의 $\beta$ -thenylalanine에 내성을 갖는 TA-40-10을 분리하였고 이 균주로부터 phenylalanine 영향요구주인 TP-4를 개발하였다. 이 TP-4균주는 발효조에서 71시간 배양시 3.7g/ $\ell$ 의 L-tryptophan을 생산하였다. 【In order to increase the tryptophan productivity of E. coli SB1007, a mutant resistant to sulfanilamide was isolated and then a tyrosine auxotroph TY-90 was derived from the sulfanilamide-resistant mutant SA3-39-16. In the test-tube culture a quantitative amount of tryptophan was accumulated in strain TY-90 but in a jar fermentor culture the productivity was lower as compared to the level obtained by the parent strain. From the double auxotrophic mutant SB2756, a revertant resistant to 2, 000 $\mu\textrm{g}$ / $m\ell$ of $\beta$ -thienylalanine, TA 40-10, was selected and then phenylalanine auxotrophs were derived from the revertant strain TA-40-10. One of the phenylalanine auxotrophs, TP-4, accumulated 3.7g/ $\ell$ of L-tryptophan after 71-hr cultivation in a jar fermentor experiment.】
On the modulus of three-component particulate-filled composites (1973)

Modulus–composition data obtained on a model three-component particulate composite comprising a finely divided dispersed rubber phase and inorganic glass beads in a poly(methyl methacrylate) (PMMA) matrix cannot be represented appropriately in terms of the multicomponent form of the well-known Kerner equation. The data are more nearly in accord with a model based on the assumption that the dispersed rubber phase and the PMMA matrix, taken together, constitute an effective matrix for the glass bead filler. Interparticle interactions are discussed in terms of a maximum packing fraction for each filler species; interspecies interactions are found to be minor for the system studied.
Role of Nb in rutile-type metal antimonates for propane ammoxidation (2007)

Il volume 172 di Studies in Surface Science and Catalysis risulta essere un numero monografico da seguente titolo: Sience and Technology in catalysis 2006
[Study on immobilization of heparin on surface of Ti-O films and its antithrombogenicity]. (2011)

Photoreactive heparin was synthesized by reaction of 4-azidoaniline and heparin. An organic layer was introduced on the surface of Ti-O by 3-aminopropylphosphonic acid assembling, and then the modified heparin was immobilized on the surface by UV irradiation. Water contact angle was used to characterize the hydrophilicity, quantitive assay was done by azure staining methods, and blood compatibility was evaluated by platelet adhesion experiment. Water contact angle of heparinized surface was smaller than that of Ti-O film, which indicated more hydrophilic property of heparinized surface. The surface density of heparin increased with the prolonging of irradiation time and the density was 2.1 microg/cm2 when irradiated for 300s. It showed the heparinized surface was effective in resisting platelets from adhesion and aggregation.
Figure S4 from BRCA1-Interacting Protein OLA1 Requires Interaction with BARD1 to Regulate Centrosome Number (2023)

&lt;p&gt;Supplementary Figure 4. BARD1 expression in Hs578T cells transfected with BARD1 siRNA and expression vector.&lt;/p&gt;
Antimycobacterial Natural Products (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Transfer ionization and double capture of helium dimers (2009)

We employed the COLTRIMS (cold target recoil ion momentum spectroscopy) technique to investigate the collision of alpha particles with an energy of 150kev/u and he lium dimers (He2).
Acid and Alkali‐Resistant Textile Triboelectric Nanogenerator as a Smart Protective Suit for Liquid Energy Harvesting and Self‐Powered Monitoring in High‐Risk Environments (2021)

Abstract Industrialization and anthropogenic activities are expected and unavoidable to consummate the current resources of humankind, which also lead to accidents in the laboratory, chemical plants, or other high risk areas that cause severe burns, or even casualties. Increased casualties in such accidents are due to inappropriate safety measures and prevention. Here, a smart anti‐chemical protective suit with a bio‐motion energy harvesting and self‐powered safety monitoring system is demonstrated, which can protect the body from chemical harm, detect sudden chemical spills, monitor human real‐time living signals, and trigger alarms in an emergency. Particularly, a fabric triboelectric nanogenerator (F‐TENG), which is fabricated by the all‐fiber single‐electrode triboelectric nanogenerator yarn (SETY), works as the basic elements of the intelligent suit. The SETY with core‐shell structured design shows a high sensitivity to the corrosive liquids including acids and alkalis. Furthermore, the working principle of the yarn based nanogenerator that is powered by contacting with acid liquid droplets is demonstrated for the first time. In addition, discretionary thickness, permeability, and any other functionalities are also achieved by taking advantage of the fabric structure. This self‐powered smart anti‐chemical protective suit equipped with a real time monitoring system will benefit the wearer who works in a very high‐risk environment.
Copper-promoted oxidative-fluorination of arylphosphine under mild conditions (2014)

An efficient method for the synthesis of phosphoric fluoride via oxidative coupling between hydrophosphine oxide and NaF is reported. DDQ serves as the oxidizing reagent as well as the hydrogen acceptor. The process involves a Cu(II) catalysis and exhibits great functional group tolerance under mild reaction conditions.
Analysis of cochlear implant artifact removal techniques using the continuous wavelet transform (2014)

When patients with cochlear implants (CI) undergo cortical auditory evoked potential (CAEP) tests to evaluate their hearing, a large electrical artifact introduced by the CI obscures the relevant information in the signal. Several methods have been developed for the purpose of removing the CI artifact; however, there is no gold standard (i.e., patient's auditory response before the CI) to assess the effectiveness of these methods in terms of successful removal of artifact. To address this crucial shortcoming, we employ time-frequency (TF) signal representation (i.e., continuous wavelet transform (CWT)) to evaluate the effectiveness of two recent CI removal techniques, known as the subtraction and polynomial methods. Our results show that polynomial method consistently outperforms the subtraction method in the presence of tone stimulus. These results also indicate a possible CWT-based method for removing the CI artifact from a speech stimuli response, which the subtraction and polynomial methods cannot do.
On the Design of Pulse-Forming Networks (1965)

A figure of merit is defined for pulse-forming networks which takes into account frequency response as well as time response, and a class of filters was found that is best in the sense of this criterion. The characteristics of these filters in the stop band and in parts of the time domain lead to a new approximation problem, which is stated in the frequency and time domain simultaneously. Numerical solutions have been obtained for the parameters of a large number of filters of different degree. The frequency response and the delay of these filters in the pass band are very unusual when compared with those of pulse-forming networks known so far. The parameters of some of these filters are given in the Appendix.
pH responsive alginate polymeric rafts for controlled drug release by using box behnken response surface design (2016)

Aim of the present work was to develop alginate raft forming tablets for controlled release pantoprazole sodium sesquihydrate (PSS). Box behnken design was used to optimize 15 formulations with three independent and three dependent variables. Physical tests of all formulations were within pharmacopoeial limits. Raft was characterized by their strength, thickness, resilience, acid neutralizing capacity, floating lag time and total floating time. Raft strength, thickness and resilience of optimized formulation AR9 were 7.43 ± 0.019 g, 5.8 ± 0.245 cm and greater than 480 min, respectively. Buffering and neutralizing capacity were 11.2 ± 1.01 and 6.5 ± 0.56 meq, respectively. Dissolution studies were performed by using simulated gastric fluid pH 1.2 and cumulative percentage release of optimized formulation AR9 was found 98%. First order release kinetics were followed and non-fickian diffusion was observed as value of n was greater than 0.45 in korsmeyer-peppas model. PSS, polymers, tablets and rafts were further characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffractometry (XRD) and differential scanning calorimetry (DSC). FTIR spectra of PSS, polymers and raft of optimized formulation AR9 showed peaks at 3223.09, 1688.17, 1586.67, 1302.64 and 1027.74 cm<sup>-1</sup> due to -OH stretching, ester carbonyl group (C=O) stretching, existence of water and carboxylic group in raft, C-N stretching and -OH bending vibration showed no interaction between them. XRD showed diffraction lines indicates crystalline nature of PSS. DSC thermogram showed endothermic peaks at 250 °C for PSS. The developed raft was suitable for controlled release delivery of PSS.
Bipartite ranking algorithm for classification and survival analysis (2011)

Unsupervised aggregation of independently built univariate predictors is explored as an alternative regularization approach for noisy, sparse datasets. Bipartite ranking algorithm Smooth Rank implementing this approach is introduced. The advantages of this algorithm are demonstrated on two types of problems. First, Smooth Rank is applied to two-class problems from bio-medical field, where ranking is often preferable to classification. In comparison against SVMs with radial and linear kernels, Smooth Rank had the best performance on 8 out of 12 benchmark benchmarks. The second area of application is survival analysis, which is reduced here to bipartite ranking in a way which allows one to use commonly accepted measures of methods performance. In comparison of Smooth Rank with Cox PH regression and CoxPath methods, Smooth Rank proved to be the best on 9 out of 10 benchmark datasets.
Differentiable Programming A La Moreau (2022)

The notion of a Moreau envelope is central to the analysis of first-order optimization algorithms for machine learning and signal processing. We define a compositional calculus adapted to Moreau envelopes and show how to apply it to deep networks, and, more broadly, to learning systems equipped with automatic differentiation and implemented in the spirit of differentiable programming.
On the Number of Fixed Pairs in a Random Instance of the Stable Marriage Problem (2007)

Consider a group of n men and n women, each ranking the members of the opposite sex as a potential marriage partner. A matching (marriage) of men and women is called stable if there is no pair (man, woman) who are not matched but prefer each other to their partners in the matching. It is known that, for every instance of the rankings, there is at least one stable matching and that there are instances with exponentially many stable matchings. Assume that the instance is chosen uniformly at random among all $(n!)^{2n}$ possibilities. In this case the likely number of stable matchings is known to be $n^{1/2-o(1)}$, with high probability, and of order $n\ln n$, with probability $0.84$ at least. In this paper we show that the average number of fixed pairs (man, woman), i.e., pairs common to all stable matchings, is asymptotic to $\ln^2 n$. More generally, the average number of women (men) with k stable husbands (wives) is asymptotic to $(\ln ^{k+1} n)/(k-1)!$.