gebhart/patrepeval huggingface dataset:
Marked activity of irofulven toward human carcinoma cells: comparison with cisplatin and ecteinascidin. (2003)

Irofulven has an unusual activity spectrum with strong activity toward tumor cells of epithelial origin. Furthermore, irofulven is not or only marginally affected by resistance mechanisms limiting the efficacy of other alkylating agents.
Direct synthesis of a new class of N,N,N ligands based on 1,2-dihydro-1,10-phenanthroline backbone and their coordination to Pd complexes (2008)

Reactions of acetylpyridine derivatives with 8-aminoquinolines provide a general and simple access to an unexpected class of versatile N,N,N ligands, which offer interesting perspectives in coordination chemistry.
Sequencing analysis of OMI/HTRA2 shows previously reported pathogenic mutations in neurologically normal controls (2008)

A novel heterozygous non-synonymous mutation and a novel polymorphism in OMI/HTRA2 locus have been associated with Parkinson's disease (PD) in a German population. In an attempt to replicate these results in an independent population, we analyzed the entire coding region of OMI/HTRA2 in a series of 644 North American PD cases with both young- and late-onset disease and in 828 North American neurologically normal controls. Our results show that neither of the variants previously related to PD were associated with PD in our cohort and that the risk variants were present in neurologically normal controls.
Frontispiece: SnI4⋅(S8)2: A Novel Adduct‐Type Infrared Second‐Order Nonlinear Optical Crystal (2018)

Nonlinear Optics. SnI4⋅(S8)2, obtained by S.-P. Guo and co-workers in their Communication on page 11540 ff. has a phase-matchable character and wide IR transparency making it a very promising IR nonlinear optical (NLO) crystal.
A frame aggregation scheduler for QoS-sensitive applications in IEEE 802.11n WLANs (2012)

The IEEE 802.11n standard promises to extend todays most popular WLAN standard by significantly increasing reach, reliability, and throughput. Ratified on september 2009, this standard defines many new physical and medium access control (MAC) layer enhancements. These enhancements aim to provide a data transmission rate of up to 600 Mbps. The frame aggregation mechanism of 802.11n MAC layer can improve the efficiency of channel utilization by reducing the protocol overheads. In this paper we investigate the effect of frame aggregation on the support of voice and video applications in wireless networks. We also propose a new frame aggregation scheduler that considers specific QoS requirements for multimedia applications. We dynamically adjust the aggregated frame size based on frame's access category defined in 802.11e standard.
Supplemental Table 12 from Expression of <i>ANRIL</i>–Polycomb Complexes–<i>CDKN2A/B/ARF</i> Genes in Breast Tumors: Identification of a Two-Gene (<i>EZH2/CBX7</i>) Signature with Independent Prognostic Value (2023)

&lt;p&gt;Relationship between P15 transcripts levels and classical clinical biological parameters in a series of 456 breast cancers.&lt;/p&gt;
Induction of protein catabolism in myotubes by 15(S)-hydroxyeicosatetraenoic acid through increased expression of the ubiquitin–proteasome pathway (2003)

The potential role of 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE) as an intracellular signal for increased protein catabolism and induction of the expression of key components of the ubiquitin-proteasome proteolytic pathway induced by a tumour cachectic factor, proteolysis-inducing factor has been studied in murine C(2)C(12) myotubes. 15(S)-HETE induced protein degradation in these cells with a maximal effect at concentrations between 78 and 312 nM. The effect was attenuated by the polyunsaturated fatty acid, eicosapentaenoic acid (EPA). There was an increase in 'chymotrypsin-like' enzyme activity, the predominant proteolytic activity of the proteasome, in the same concentration range as that inducing total protein degradation, and this effect was also attenuated by EPA. 15(S)-hydroxyeicosatetraenoic acid also increased maximal expression of mRNA for proteasome subunits C2 and C5, as well as the ubiquitin-conjugating enzyme, E2(14k), after 4 h incubation, as determined by quantitative competitive RT-PCR. The concentrations of 15-HETE affecting gene expression were the same as those inducing protein degradation. Western blotting of cellular supernatants of myotubes treated with 15(S)-HETE for 24 h showed increased expression of p42, an ATPase subunit of the regulatory complex at similar concentrations, as well as a decrease in expression of myosin in the same concentration range. 15(S)-hydroxyeicosatetraenoic acid activated binding of nuclear factor-kappaB (NF-kappaB) in the myotube nucleus and stimulated degradation of I-kappaBalpha. The effect on the NF-kappaB/I-kappaBalpha system was attenuated by EPA. In addition, the NF-kappaB inhibitor peptide SN50 attenuated the increased chymotrypsin-like enzyme activity in the presence of 15(S)-HETE. These results suggest that 15(S)-HETE induces degradation of myofibrillar proteins in differentiated myotubes through an induction of an increased expression of the regulatory components of the ubiquitin-proteasome proteolytic pathway possibly through the intervention of the nuclear transcription factor NF-kappaB, and that this process is inhibited by EPA.
483 Partial Treatment as a Risk Factor in Up-Conversion of Type 1 dAVFs (2023)

INTRODUCTION: Type 1 dural arteriovenous fistulas (dAVFs) lack cortical venous drainage and occasionally necessitate intervention depending on patient symptoms. Up-conversion is the rare transformation of a dAVF to a higher-grade. Causes for up-conversion are unknown. We tested the hypothesis whether partial treatment of type 1 dAVFs increases their likelihood of up-conversion. METHODS: We used the multicenter Consortium for Dural Arteriovenous Fistula Outcomes Research (CONDOR) database to perform a retrospective analysis of all patients with type 1 dAVFs. Propensity score analysis was utilized to determine if partial treatment was an independent risk factor for up-conversion. A regression model identified secondary risks that contributed to up-conversion. RESULTS: 358 out of 1077 patients within the consortium had type 1 dAVFs. 12% of patients who were partially treated for a type 1 dAVF experienced an up-conversion, while less than 1% of patients who received no treatment experienced up-conversion, and 0% of patients who had a complete treatment of their dAVF experienced up-conversion. Higher proportions of tinnitus, bruits, and intracranial hemorrhage at initial presentation were found in patients who up-converted. The majority of up-converted dAVFs were located in the transverse-sigmoid sinus and all received embolization as part of their treatment. CONCLUSIONS: Partial treatment is an independent risk factor for up-conversion when compared to no treatment or complete treatment. In the partial treatment group, hemorrhage at inital presentation and use of embolization as a treament modality are factors that increase risk for up-conversion.
Correlations in nondegenerate parametric oscillation. II. Below threshold results (1990)

We develop the quantum theory of a driven, damped intracavity parametric oscillator in the case of nondegenerate signal and idler modes. An analysis of the results of different types of local-oscillator measurements on the outgoing modes is presented. The frequency-domain squeezing is calculated below threshold including the effect of detunings and nonequal decay rates. We also calculate a nonclassical correlation in the quadrature amplitudes of the output beams. The existence of an Einstein-Podolsky-Rosen paradox is demonstrated through violations of the inferred Heisenberg uncertainty principle at causally unrelated locations in the output field. This provides a way of maintaining the commutation relations of the measured operators in the exact form envisaged originally by Einstein, Podolsky, and Rosen.
Comparative Performance Analysis of Hamming, Hanning and Blackman Window (2014)

In the emerging field of medical image processing, computer vision, pattern recognition and other digital signal processing applications, window technique is vastly used. A window function is a mathematical function that is zero-valued outside of some chosen interval. When another function is multiplied by a window function, the product is also zero-valued outside the interval. In this paper, the performance of Hamming, Hanning and Blackman window have been mainly compared considering their magnitude response, phase response, equivalent noise bandwidth, sidelobe transition width, response in time and frequency domain using MATLAB simulation. To observe the responses, a FIR filter of low pass, high pass, band pass and band stop type have been designed and encountered them with each parameters stated above. The results that have been found is as same as its to be as stated in the theory. Comparing simulation results of different window, this paper has found Blackman window with best performance among them which is also expected from the theory. These windows have also been encountered with speech signal using MATLAB simulation and found the same expected result.
Ultra-low Thermal Conductivity in Si/Ge Hierarchical Superlattice Nanowire (2015)

Due to interfacial phonon scattering and nanoscale size effect, silicon/germanium (Si/Ge) superlattice nanowire (SNW) can have very low thermal conductivity, which is very attractive for thermoelectrics. In this paper, we demonstrate using molecular dynamics simulations that the already low thermal conductivity of Si/Ge SNW can be further reduced by introducing hierarchical structure to form Si/Ge hierarchical superlattice nanowire (H-SNW). The structural hierarchy introduces defects to disrupt the periodicity of regular SNW and scatters coherent phonons, which are the key contributors to thermal transport in regular SNW. Our simulation results show that periodically arranged defects in Si/Ge H-SNW lead to a ~38% reduction of the already low thermal conductivity of regular Si/Ge SNW. By randomizing the arrangement of defects and imposing additional surface complexities to enhance phonon scattering, further reduction in thermal conductivity can be achieved. Compared to pure Si nanowire, the thermal conductivity reduction of Si/Ge H-SNW can be as large as ~95%. It is concluded that the hierarchical structuring is an effective way of reducing thermal conductivity significantly in SNW, which can be a promising path for improving the efficiency of Si/Ge-based SNW thermoelectrics.
Phenolic content and in vitro inhibitory effects on oxidation and protein glycation of some Thai medicinal plants. (2010)

Fifteen medicinal plant extracts were investigated for: total phenolic content and free radical scavenging effect by DPPH and ABTS assays; anti-lipid peroxidation activity by TBARS; and for antiglycation activity. The results revealed that the total phenolic content showed good correlation with free radical scavenging by ABTS (r = 0.721) and anti-lipid peroxidation by TBARS (r = -0.659), but showed no correlation with antiglycation. Three extracts from Tamarindus indica, Camellia sinensis and Artocarpus lakoocha demonstrated a significant antioxidant effect, and also showed a promising antiglycation effect. The IC50 (mg/ml) were 0.9-0.16 for the DPPH method; TEAC values (mg Trolox/mg sample) of 1.72-2.83 for the ABTS method; IC50 (mg/ml) of 0.64-1.22 for the TBARS method; and IC50 ranging from 0.01 to 3.20 for the antiglycation method. These three herbs were found to possess effective antioxidant and antiglycation activities, and could be further developed for use in anti-aging cosmetics.
Monophasic and biphasic synovial sarcomas abundantly express cancer/testis antigen ny-eso-1 but not mage-a1 or ct7 (2001)

Synovial sarcomas are high-grade malignant mesenchymal tumors with biphasic (BSS) and monophasic (MSS) variants that carry a pathognomonic cytogenetic alteration, t(X;18), involving the SYT gene on chromosome 18 and one of several SSX genes on chromosome X, usually SSX1 or SSX2. Cancer/testis (CT) antigens are expressed in a variety of malignant neoplasms but, in normal tissues, are restricted to male germ cells. Previous analysis revealed a high incidence and homogeneous expression of MAGE CT antigen in synovial sarcomas. The present study was performed to analyze the expression of 3 CT antigens, NY-ESO-1, MAGE-A1 and CT7, by immunohistochemistry with 3 monoclonal antibodies (MAbs), ES121 (anti-NY-ESO-1), MA454 (anti-MAGE-A1) and CT7-33 (anti-CT7), in 25 synovial sarcomas (12 MSS, 13 BSS) typed for the t(X;18)-derived fusion transcript by RT-PCR (19 SYT-SSX1, 6 SYT-SSX2). NY-ESO-1 immunoreactivity was found in 20/25 (80%) cases, and antigen expression was homogeneous in 14/20 NY-ESO-1-positive cases. Both morphologic variants and both translocation types were NY-ESO-1-positive, whereas 5 SYT-SSX1 tumors (1 MSS, 4 BSS) were NY-ESO-1-negative. MAb MA454 was immunoreactive with 4/25 cases (2 MSS, 2 BSS; 3 SYT-SSX1, 1 SYT-SSX2), and MAb CT7-33 was immunoreactive with only 2/25 cases (both BSS, SYT-SSX1). Expression of MAGE-A1 and CT7 was heterogeneous in all positive cases. Our study shows that NY-ESO-1 is highly expressed in a homogeneous pattern in synovial sarcomas of both morphologic variants and both translocation types, making these tumors an attractive target for NY-ESO-1 antigen-based immunotherapy.
On the Solitary Wave and Periodic Wave Solutions of the Nonlinear Drift-Wave Equation Arising from Magnetized Plasmas (2011)

In this paper, solitary wave and periodic wave solutions of the nonlinear drift-wave equation arising from magnetized plasmas are investigated based on the steady bifurcation and energy integral of the conservative dynamical system satisfied by the traveling waves. Conditions for the existence of solitary waves and periodic waves are given in terms of a bifurcation control parameter and the initial energy. Simplified formulations are obtained for the periodic wave solutions by developing an approximate method.
Measurement of aspheric mirror by nanoprofiler using normal vector tracing (2016)

Aspheric or free-form optics with high accuracy are necessary in many fields such as third-generation synchrotron radiation and extreme-ultraviolet lithography. Therefore the demand of measurement method for aspherical or free-form surface with nanometer accuracy increases. Purpose of our study is to develop a non-contact measurement technology for aspheric or free-form surfaces directly with high repeatability. To achieve this purpose we have developed threedimensional Nanoprofiler which detects normal vectors of sample surface. The measurement principle is based on the straightness of laser light and the accurate motion of rotational goniometers. This machine consists of four rotational stages, one translational stage and optical head which has the quadrant photodiode (QPD) and laser source. In this measurement method, we conform the incident light beam to reflect the beam by controlling five stages and determine the normal vectors and the coordinates of the surface from signal of goniometers, translational stage and QPD. We can obtain three-dimensional figure from the normal vectors and their coordinates by surface reconstruction algorithm. To evaluate performance of this machine we measure a concave aspheric mirror with diameter of 150 mm. As a result we achieve to measure large area of 150mm diameter. And we observe influence of systematic errors which the machine has. Then we simulated the influence and subtracted it from measurement result.
Compression research on the REINAS Project (1995)

We present approaches to integrating data compression technology into a database system designed to support research of air, sea, and land phenomena of interest to meteorology, oceanography, and earth science. A key element of the Real-Time Environmental Information Network and Analysis System (REINAS) system is the real-time component: to provide data as soon as acquired. Compression approaches being considered for REINAS include compression of raw data on the way into the database, compression of data produced by scientific visualization on the way out of the database, compression of modeling results, and compression of database query results. These compression needs are being incorporated through client-server, API, utility, and application code development.
Active Sloshing Control by Using Movable Plates Device Based on Flow Control Method (2009)

This paper deals with an experimental study of an active control technique for the suppression of sloshing based on flow control in the tank. In this paper, we proposed the active feedback control method by using movable plates which are set in liquid. In the experiment, the present method is applied to the 2-dimensional problem of sloshing which occurs in the rectangular tank due to a horizontal excitation. The sloshing are suppressed by the active feedback to the rotation of the movable plate installed in liquid. The suppression performances are examined by changing the phase difference between the control signal of rotation angles of the movable plate and the liquid surface displacement (phase-shift). The performance of proposed method is evaluated by the time history, the root mean square value and frequency-response of the surface wave displacement under the active feedback control. Moreover, the effects of movable plate number and installation position on the suppression performance are clarified. On the other hand, the visualization experiment is conducted to obtain the flow pattern in the tank when the sloshing is controlled by the present method. The decreasing mechanism of the surface wave is discussed by the result of the visualization experiment. As a result, it is shown that the proposed control devics and active control method suppress the sloshing effectively. Furthermore, it is found that the changes of flow pattern by the drive of movable plate cause the suppression of sloshing in the visualization experiment.
Nitric oxide inhibits 3H‐glutamate transport in synaptosomes (1994)

3H-glutamate (GLU) uptake was measured in hippocampal synaptosomes from rat brain. Addition of sodium nitroprusside (SNP) (Sodium nitroferricyanide), a generator of nitric oxide (NO), produced a time-, temperature-, and dose-dependent inhibition of 3H-GLU uptake. The inhibition was due to changes in both Kd and Vmax of GLU uptake, and it was at least partially reversible upon washing. Addition of reduced hemoglobin (Hb), a substance that binds NO, prevented the SNP-induced depression of uptake. Potassium ferricyanide, a compound similar to SNP, did not cause a reduction in 3H-GLU uptake. Utilization of another generator of NO, S-nitroso-N-acetylpenicillamine (SNAP), produced similar results as did NO itself. Decreases in uptake were also observed in the striatum and cerebellum. Similar treatments did not consistently affect 3H-norepinephrine (NE) uptake, suggesting some selectivity in the NO effect. Thus, the observed inhibition of 3H-GLU uptake appears to be produced by NO, and it may represent a novel type of transynaptic retrograde regulation of transport. If found in vivo, inhibition of uptake activity could also be involved in the toxic effects of NO, the neurotoxicity of glutamate, and other potential neuronal changes associated with NO such as hippocampal long-term potentiation.
Phosphopeptide Binding Specificities of BRCA1 COOH-terminal (BRCT) Domains (2003)

Protein phosphorylation by protein kinases may generate docking sites for other proteins. It thus allows the assembly of signaling complexes in response to kinase activation. Several protein domains that bind phosphoserine or phosphothreonine residues have been identified, including the 14-3-3, PIN1, FHA, KIX, WD-40 domain, and polo box (Yaffe, M. B., and Elia, A. E. (2001) Curr. Opin. Cell Biol. 13, 131-138; Elia, A. E., Cantley, L. C., and Yaffe, M. B. (2003) Science 299, 1228-1231). The BRCA1 COOH-terminal (BRCT) domains are protein modules found in many proteins that regulate DNA damage responses (Koonin, E. V., Altschul, S. F., and Bork, P. (1996) Nat. Genet. 13, 266-268). Whether BRCT domains can mediate phosphorylation-dependent interactions has not been systematically investigated. We report here that the BRCT domains also recognize phosphopeptides. Oriented peptide library analysis indicated that the BRCT domains from BRCA1, MDC1, BARD1, and DNA Ligase IV preferred distinct phosphoserine-containing peptides. In addition, the interaction between BRCA1 and the BRCT binding motif of BACH1 was required for BACH1 checkpoint activity. Furthermore, BRCT domains of the yeast DNA repair protein Rad9 could bind phosphopeptides, suggesting that the BRCT domains represent a class of ancient phosphopeptide-binding modules. Potential targets of BRCT domains were identified through data base search. Structural analysis of BRCA1 BRCT repeats also predicted conserved residues that may form the phosphopeptide-binding pocket. Thus, the BRCT repeats are a new family of phosphopeptide-binding domains in DNA damage responses.
Papain-Assisted Resolution of Natural and Xenobiotic α-Amino Acid (1988)

Abstract A new and convenient method for the preparation of pure enantiomers of α-amino acids is described. Industrial papain, catalyzes the synthesis of L-Z-amino acid ethyl esters in ethanolic medium, with good yields. These esters are obtained from DL-Z-amino acids with 100% optical purity. Unreactive D-Z-amino acids are readily isolated from reaction medium. Physical constants of natural and xenobiotic L-Z-amino acid esters and D-Z-amino acids are described.
Choosing the Correct Bulk Loading Equipment Can Help Optimize Your Blasting Program (2001)

This contribution addresses the development and use of heavy ANFO type bulk loading units. It is shown that using computer-aided design methodologies and modular design capabilities taylored optimal bulk loading units can be fabricated. The paper also reviews the range of equipment currently available in the market place and discusses tradeoffs between price, capacity, and complexity.
Identification of lipoprotein lipase immunoreactive protein in pre- and postheparin plasma from normal subjects and patients with type I hyperlipoproteinemia. (1990)

Postheparin plasma is a convenient source for the measurement of lipoprotein lipase (LPL) in humans. Previous studies have focused on the measurement of LPL catalytic activity, and have been unable to conveniently measure the LPL protein or identify possibly different plasma forms of the enzyme. Pre- and postheparin plasma was treated with a highly specific antibody raised against bovine milk LPL and the immunoprecipitate was analyzed by Western blotting. In normal subjects there were several species of LPL in plasma. A 56 kD protein increased after heparin injection, and likely represented active LPL. The anti-LPL antibody reacted specifically with this 56 kD protein, and also reacted specifically with proteins at 52 kD, 69 kD, as well as a 20 kD breakdown product. In addition, using peptide mapping, the 56 kD protein was structurally similar to the 52 and 69 kD LPL proteins. The antibodies were affinity purified, biotinylated, and used to quantitate LPL immunoreactive mass using an enzyme-linked immunosorbent assay (ELISA). LPL immunoreactive mass was present in all subjects in preheparin plasma. In postheparin plasma, five patients with type I hyperlipoproteinemia displayed decreased LPL immunoreactive mass when compared to normal subjects, although there was a wide range of specific activity of the small amount of enzyme present. When the LPL from the plasma of the patients was immunoprecipitated and Western blotted, there was considerable heterogeneity in the appearance of the LPL forms, and an overall decrease in LPL protein. Thus, several different immunoreactive LPL proteins were present in pre- and postheparin plasma. In preheparin plasma, as well as in patients with type I hyperlipoproteinemia, there was decreased immunoreactive LPL protein, and the LPL protein that was present was of low specific activity.