gebhart/patrepeval huggingface dataset:
Multi-granularity time-constraint Role-based access control (2008)

The research work of basic Role-based access control RBAC is greatly emphasized in recent years. However, many of present works have nothing to do with the time character. After detail analysis about the RBAC 2004 model, a new RBAC model with multi-granularity time character called MG-TRBAC is proposed. In our new access control model, user, object, permission and roles are all temporal sensitive. Time constraints are measured by more than one granularity and can be implemented implicitly. The most interesting character in our access control model is that MG-TRBAC can adjust the minimum time unit threshold automatically; therefore, our access control model can save time and computational work deeply and efficiently.
Pre-Clinical Validation of Polo-Like Kinase 1 as a Therapeutic Target in Multiple Myeloma with the Selective Inhibitor BI2536. (2007)

Abstract BACKGROUND: The centrosome is the cellular organelle that nucleates the mitotic spindle. Polo-like kinase 1 (Plk1), a centrosome-associated serine/threonine kinase, serves as a key regulator of multiple steps in mitosis. Plk1 is overexpressed in a broad spectrum of tumor types, and its expression often correlates with poor patient prognosis. We have previously observed centrosome amplification in myeloma, and have validated other components of the myeloma centrosome and mitotic apparatus as therapeutic targets. The present study explored the expression of Plk1 in myeloma and the effect of BI2536, a potent and selective inhibitor of Plk1, on myeloma cells in the pre-clinical setting. METHODS: Plk1 expression was assayed in a panel of myeloma cell lines (MMCL) and AutoMACS-purified CD138+ patient bone marrow plasma cells (BMPC). The anti-myeloma effects of BI2536, alone or in combination with conventional agents, were assayed on myeloma cells with proliferation (MTS) and apoptosis (Annexin V/propidium iodide) assays. The phenotype of treated cells was examined with DNA content analysis and immunofluorescence microscopy. The efficacy of BI2536 monotherapy was evaluated in NOD/SCID mice bearing RPMI8226 xenografts. RESULTS: Plk1 is ubiquitously expressed in myeloma to varying degrees in both MMCL and BMPC. BI2536 inhibited the proliferation of MMCL (RPMI 8226, U266, LP-1 and KMS-11) and patient BMPC at nanomolar concentrations. The addition of BI2536 was able to overcome resistance to dexamethasone. Bortezomib in combination with BI2536 had significantly increased anti-myeloma effects compared to the use of either agent alone. BI2536-treated MMCL accumulated 4N DNA content prior to undergoing apoptosis. The phenotype of BI2536-treated cells is consistent with inhibition of Plk1, showing prometaphase arrest and monopolar mitotic spindles in a dose-dependent fashion. BI2536 induces regression of human myeloma xenografts in NOD/SCID mice. Taken together, BI2536 is a promising new agent for the treatment of multiple myeloma. This work provides further evidence that Plk1 and the amplified myeloma centrosome are targets for therapy.
[Observation of intraoperative lower limb blood flow of infrarenal aortic occlusion]. (2012)

Doppler blood flow and blood oxygen saturation monitors are simple, non-invasive and objective detection methods for lower limb blood flow. A combination of both methods can improve the safety of surgery. Keeping the limbs warm and uses of spasmolytic drugs can facilitate the recovery of postoperative blood flow of lower limbs.
Natural killer cells in asthma (2016)

NK cells are nonredundant participants of allergic inflammation. The environmental context determines whether NK cells act as protagonists or antagonists.
Cell Culture Adaptation of H3N2 Influenza Virus Impacts Acid Stability and Reduces Ferret Airborne Transmission (2021)

Airborne transmission of seasonal and pandemic influenza viruses is responsible for their epidemiological success and public health burden in humans. Efficient airborne transmission of H1N1 influenza virus relies on receptor specificity and pH of fusion of the surface glycoprotein hemagglutinin (HA). In this study, we examine the role of HA pH of fusion on transmissibility of a cell culture-adapted H3N2 virus. Mutations in the HA head at positions 78 and 212 of A/Perth/16/2009 (H3N2), which were selected after cell culture adaptation, decrease the acid stability of the virus from a pH of 5.5 (WT) to 5.8 (mutant). In addition, we observed that this mutant H3N2 virus replicated to higher titers in cell culture but had reduced airborne transmission in the ferret model. These data demonstrate that, like H1N1 HA, the pH of fusion for H3N2 HA is a determinant of efficient airborne transmission. Surprisingly, we demonstrate that the NA segment noncoding regions can impact the pH of fusion of reassortant viruses. Taken together, our data confirm that HA acid stability is an important characteristic of epidemiologically successful human influenza viruses and is influenced by HA/NA balance.
Distribution of substance P and the calcitonin gene-related peptide in the human tensor tympani muscle (2013)

Substance P-immunoreactive nerve fiber (SP-IR NF) and calcitonin gene-related peptide-immunoreactive nerve fiber (CGRP-IR NF) are important mediators of neurogenic inflammation and blood supply. SP-IR and CGRP-IR NFs in the tensor tympani muscle (TTM) of the human middle ear have yet to be described. In this study, the TTM, tympanic membrane, malleus in the middle ear and tensor veli palatini muscle (TVPM) were examined by whole-mount immunohistochemistry in tissue from Japanese subjects. Thirteen human cadavers (ranging in age from 46 to 90 years) were used in this study. SP-IR and CGRP-IR NFs were primarily found on vessels at the origin, insertion and belly of the surface of the TTM and on the internal surface of the tympanic membrane. These neural factors were also detected on the surface of the malleus and the insertion of the TVPM. Therefore, our results indicate that existence of the SP-IR and CGRP-IR NFs of the TTM and the TVPM may reflect muscle properties involved in pain or inflammation of the middle ear.
[Interphasic in situ fluorescent hybridization (FISH) in 4 cases of myeloid neoplasias with chromosome 7 changes]. (1994)

The use of FISH as a complement to the conventional cytogenetic studies is of great help in attaining a better characterisation of the chromosome anomalies present in haematological malignancies, such as chromosome 7 monosomy. A study was carried out in three cases of acute non-lymphoblastic leukaemia and a myelodysplastic syndrome with chromosome 7 involvement, as shown by conventional cytogenetic studies. The Cocktail probe for chromosome 7 (DZ1, DZ2) was used (Oncor) in performing in situ hybridation. A monosomic cell line for chromosome 7, undetected by conventional techniques, was disclosed with this procedure in two of the cases. In the remaining two patients the monosomy of chromosome 7 was confirmed, although at percentages different from those attained with the conventional methods.
CINA - A Crowdsourced Indoor Navigation Assistant (2013)

With the rise of well-equipped mobile devices in the last years, there is an increasing interest in location based services (LBS). Current LBS mostly cover outdoor scenarios. Indoor LBS just begin to emerge due to technical boundaries. Especially generic indoor navigation assistants for smartphones are still missing or require an extensive infrastructure. Whereas current research is trying to tackle spatial indoor positioning in various ways based on absolute positioning and floor-plans, this project doesn't rely on sensors but solely on relative positioning with crowd sourced information. We use aggregated path information of buildings, consisting of an ordered instruction list recorded and evaluated by users. The concept was experimentally evaluated with a prototype for an indoor navigation assistant that is independent from floor-plans and infrastructure. The evaluation has shown that our concept is practically usable and the implementation is a user-friendly and infrastructure-less system operating at low cost.
Dissecting the Streptavidin-Biotin Interaction by Phage-Displayed Shotgun Scanning (2002)

Shotgun scanning the streptavidin-biotin interaction identifies long-range hydrophobic interactions that contribute to one of the strongest naturally occurring noncovalent protein-ligand interactions. The femtomolar dissociation constant for this interaction makes it a useful model system to dissect the forces that govern high-affinity molecular recognition between proteins and small molecules. Shotgun scanning combines the diversity and in vitro binding selection of phage-displayed libraries with a binomial mutagenesis strategy. Libraries consist of proteins with the residues in multiple positions mutated to give a 1:1 ratio of alanine:wild type. Here, we use shotgun scanning to determine the functional contribution of the 38 C-terminal residues of streptavidin to the high-affinity interaction with biotin. The library pools were subjected to three rounds of selection for functional streptavidin variants that bind biotin and statistical analysis was used to assess side-chain contributions to biotin binding. The results demonstrate the utility of shotgun scanning for the dissection of receptor-small-molecule interactions. While shotgun scanning results were largely consistent with previous single-point, site-directed mutagenesis studies for residues in direct contact with biotin, residues distant from the biotin binding site have not previously been explored. Key streptavidin residues identified by shotgun scanning as contributors to the interaction with biotin include those with side chains that fill the beta barrel, residues at the tetramer interface, and second-sphere residues, which are reinforced by long-distance propagation of hydrophobic interactions.
Technology, Preparation, and Characterization (2015)

The preparation and production of bulk High – Temperature Superconductors (HTS) since the discovery is analysed and reported in their development and progress. For the three material groups REBCO (RE: Y, Sm, Gd, Nd, …), BiSCCO (Bi2122, Bi2223), and MgB2 the processing routes are described and evaluated. While BiSCCO compounds play an important role in the conductor development the REBCO melt texture processes provide large crystalline bulks for magnetic application. Top-seed melt growth (TSMG) fabrication methods dominate the bulk production by using single or multiple seeds to prevent unwanted parasitic multi- crystalline nucleation. Large single grain bulk fabrication of 50–100 mm requires exact precursor phase preparation of RE123 and RE211 and a temperature/ oxygen-controlled furnace process. Multiple seeding of large plane bulks, rings and cylinders improves the magnetic properties and ensures an optimum geometry for application. Doping strategy of REBCO bulks is reviewed and the mechanical limitations of REBCO bulks under high trapped field values above 5 Tesla explained. Bulk HTS are characterized by measurements of the critical current density and the maximum magnetic trapped flux density. Physical properties of bulk HTS are given and the magnetic performance of the different REBCO materials (RE= Y, Sm, Nd, Gd) compared in view of applicability.
Manufacturing products with end-of-life considerations: an economic assessment to the routes of revenue generation from mature products (1998)

This paper presents improved models of the economics of the options that can be taken at the end of the first life of a product. The options of resale, remanufacture, upgrade, recycling, and scrap were examined. These option models are compared with current commercial data and this comparison is used to generate empirical constants for elements of each model. These combined empirical and analytical models are then used to explore the economics of mixed end-of-life strategies for mature electronics products. The limitations of the models with respect to high value add and upgrade are explored.
Exosomal MicroRNA-223, MicroRNA-146, and MicroRNA-21 Profiles and Biochemical Changes in Laryngeal Cancer (2023)

Laryngeal squamous cell carcinoma (LSCC) is one of the most aggressive cancers, and its early diagnosis is urgent. Exosomes are believed to have diagnostic significance in cancer. However, the role of serum exosomal microRNAs, miR-223, miR-146, and miR-21, and phosphatase and tensin homologue (PTEN) and hemoglobin subunit delta (HBD) mRNAs in LSCC is unclear. Exosomes were isolated from the blood serum of 10 LSCC patients and 10 healthy controls to perform scanning electron microscopy and liquid chromatography quadrupole time-of-flight mass spectrometry analyses to characterize them and to undergo reverse transcription polymerase chain reaction to identify miR-223, miR-146, miR-21, and <i>PTEN</i> and <i>HBD</i> mRNA expression phenotypes. Biochemical parameters, including serum C-reactive protein (CRP) and vitamin B12, were also obtained. Serum exosomes of 10-140 nm were isolated from LSCC and controls. Serum exosomal miR-223, miR-146, and <i>PTEN</i> were found to be significantly decreased (<i>p</i> < 0.05), in contrast to serum exosomal miRNA-21 (<i>p</i> < 0.01), and serum vitamin B12 and CRP (<i>p</i> < 0.05) were found to be significantly increased, in LSCC vs controls. Our novel data show that the combination of reduced serum exosomal miR-223, miR-146, and miR-21 profiles and biochemical alterations in CRP and vitamin B12 levels may be useful indicators of LSCC that could be validated by large studies. Our findings also suggest a possible negative regulatory effect of miR-21 on <i>PTEN</i> in LSCC, encouraging a more extensive investigation of its role.
Erwiderung auf die Bemerkung von R. Radeglia zum Vorschlag zur Berechnung individueller Aktivitätskoeffizienten einzelner Ionensorten (1978)

Article Erwiderung auf die Bemerkung von R. Radeglia zum Vorschlag zur Berechnung individueller Aktivitätskoeffizienten einzelner Ionensorten was published on March 1, 1978 in the journal Zeitschrift für Physikalische Chemie (volume 259O, issue 1).
Correcting for sparsity and non-independence in glycomic data through a systems biology framework (2019)

Abstract Glycans are fundamental cellular building blocks, involved in many organismal functions. Advances in glycomics are elucidating the roles of glycans, but it remains challenging to properly analyze large glycomics datasets, since the data are sparse (each sample often has only a few measured glycans) and detected glycans are non-independent (sharing many intermediate biosynthetic steps). We address these challenges with GlyCompare, a glycomic data analysis approach that leverages shared biosynthetic pathway intermediates to correct for sparsity and non-independence in glycomics. Specifically, quantities of measured glycans are propagated to intermediate glycan substructures, which enables direct comparison of different glycoprofiles and increases statistical power. Using GlyCompare, we studied diverse N-glycan profiles from glycoengineered erythropoietin. We obtained biologically meaningful clustering of mutant cell glycoprofiles and identified knockout-specific effects of fucosyltransferase mutants on tetra-antennary structures. We further analyzed human milk oligosaccharide profiles and identified novel impacts that the mother’s secretor-status on fucosylation and sialylation. Our substructure-oriented approach will enable researchers to take full advantage of the growing power and size of glycomics data.
Comparison of two apheresis systems for the collection of CD14+ cells intended to be used in dendritic cell culture (2003)

The Astec is more efficient in 5-L MNC collections compared to the Spectra. Components with high residual PLTs result in high MNC loss by purification procedures. Thus, optimizing MNC programs is essential to obtain components with high MNC yields and low residual cells as prerequisite for high DC yields.
Minimal error-trellises for linear block codes (2002)

An error-trellis is an efficient means to accomplish maximum likelihood decoding of a linear (n,k) block code C over GF(q). It represents the coset of C that contains the symbol-by-symbol detected version of the received vector. The trellis we construct has only n-k sections and the structure of each section is determined solely by the value of an associated q-ary symbol of the syndrome. Hence, the entire set of q/sup n-k/ trellises for all the cosets of C is formed by a set of q(n-k) distinct sections. The error-trellis is invariant under permutation of coordinates and attains the vertex count of a minimal code-trellis with the same sectionalization.
Molecular genetics of the ichthyoses (2004)

The ichthyoses are a large, clinically, genetically, and etiologically heterogeneous group of disorders of cornification due to abnormal differentiation and desquamation of the epidermis. Although they differ in clinical features, inheritance, and structural and biochemical abnormalities of the epidermis, they often pose a diagnostic challenge. For each of the 12 ichthyoses and related disorders described here, the major disease genes have been identified and genotype-phenotype correlation have begun to emerge. The molecular findings reveal the functional importance and interactions of many different epidermal proteins and metabolic pathways, including major structural proteins (keratins, loricrin), enzymes involved in lipid metabolism (transglutaminase 1, lipoxygenases, fatty aldehyde dehydrogenase, steroid sulfatase, glucocerebrosidase, Delta8-Delta7 sterol isomerase, 3beta-hydroxysteroid dehydrogenase), and protein catabolism (LEKTI), peroxisomal transport and processing (Peroxin 7 receptor, Phytanoyl-CoA hydroxylase) and DNA repair (proteins of the transcription repair complex). This review highlights the spectacular advances in the molecular genetics and biology of heritable ichthyoses over the past decade. It illustrates the power of molecular diagnostics for refining disease classification, providing prenatal diagnosis, improving genetic counseling, and clinical management.
Structural Transitions in Triblock Copolymers Based on Poly(ethylene oxide) and Polyacrylamide under the Temperature Influence (2005)

Abstract Thermal transitions in the bulk structure of triblock copolymers (PAA‐ b ‐PEO‐ b ‐PAA) based on polyacrylamide and poly(ethylene oxide) with varying molecular weight (length) of PEO block comparing with the structures of individual polymers and polymer mixtures were investigated. A lot of effects, such as the melting temperature depression, decreasing of the crystallinity degree of PEO and also appearance of the microphase separation in amorphous regions of the polymer mixtures and the triblock copolymers were found. Such investigations pointed to a strong intramolecular interaction of the polymer blocks in the triblock copolymers that is confirmed by the results of IR spectroscopy. It was shown that PEO and PAA blocks formed the system of H‐bonds with participant of trans ‐multimers of amide groups.
ChemInform Abstract: Regioselective Synthesis of Rare 3‐Halomethylphenols Based on Formal [3 + 3] Cyclizations of 1,3‐Bis(trimethylsilyloxy)‐1,3‐butadienes. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
DC voltage balancing control of large-scale modular multilevel cascade converter (2013)

The modular multilevel cascade converter is one of the most practical solutions for high-voltage, large-capacity utility applications. As the number of the series connected submodules increases, the DC voltage balancing control becomes difficult. Problems of the conventional balancing method, when used in those large-scale modular multilevel cascade converter, has been analyzed. A new balancing control strategy has been proposed. Comparative experiments have been carried out on a real 35kV/40MVA cascade multilevel converter to verify effectiveness of the presented balancing control scheme.
Visible covalent click chemistry via macroscopic gel assembly (2023)

Macroscopic ‘click’ covalent assembly using azide/alkyne functionalized polymer hydrogels was studied. It is achieved by amplifying chemoselective alkyne-azide click reaction through interfacial multisite interactions. The underlying LEGO-like building process could be generalized with the help of click chemistry. Macroscopic assembly of hydrogels via host–guest chemistry or non-covalent interactions such as electrostatic interactions has been reported. Unlike macroscopic supramolecular assembly, here we report visible ‘click’ covalent assembly of hydrogels at macroscale. PAAm hydrogels modified with alkyne and azide groups, respectively, can click together via formation of covalent bonds. Monomer concentration-dependent assembly and selective covalent assembly have been conducted. Notably, macroscopic gel assembly clearly elucidates the substrate selectivity not observed in the solution reactions of competing monomers.
Low cardiovascular risk and poor quality of life associated with tobacco use and skin infections in adult atopic dermatitis: result of a French multicenter study (2019)

International audience
Marine terpenes and terpenoids. V. Oxidation of sarcophytol A, a potent anti-tumor-promoter from the soft coral sarcophyton glaucum. (1988)

Sarcophytol A (1a), a potent anti-tumor-promotor cembranoid from the soft coral Sarcophyton glaucum, was subjected to various oxidation reactions. m-Chloroperbenzoic acid oxidation of 1a gave two epoxides (2a, 2b) which were converted to the corresponding diols 6b, 11b, 12b, 12'b and triols 4b, 9b. Lithium aluminum deuteride reduction of 2a gave a C-7 monodeuterated diol; this was used as a model experiment for the tritiation of 1a. Chromic acid oxidation of 1a gave seco-cembranoids 13b-18, a dienone 19, and a dihydrofuran derivative 20a. Sarcophytol A acetate (1b) was less reactive in chromic acid oxidation and afforded a seco-aldehyde 22a and a dihydroxy derivative 23a in low yield. Hydrolysis of 22a followed by acid treatment afforded the furan 18. Hydrolysis of 23a gave a triol, which, on further oxidation, gave the aldehyde 16, the major product of the chromic acid oxidation of 1a.
[Methylotrophic bacteria in the sphere of drinking water. 2. Communication: biochemical/physiological and morphological characterisation of the isolated bacteria]. (1982)

720 bacteria from 18 water samples were isolated under conditions which are expected to be selective for methylotrophic bacteria. The water samples derived from 11 different water plants including 5 which had to treat methane containing groundwater. All isolates had been characterized by 130 properties using the morphological features of the colonies and the cells as well as physiological and biochemical tests. Numerical and classical principles of taxonomy were applied to the data. Only 20% of the isolated bacteria pointed out to be methylotrophic, even the portion of obligate methylotrophic organisms was only 1%.