gebhart/patrepeval huggingface dataset:
Heterolytic Cleavage of Disulfides by Frustrated Lewis Pairs (2009)

The addition of diphenyl disulfide (PhSSPh) to tBu(2)P(C(6)F(4))B(C(6)F(5))(2) (1) affords the zwitterionic phosphonium borate [tBu(2)P(SPh)(C(6)F(4))B(SPh)(C(6)F(5))(2)] (2), while the addition of a base or donor solvent to 2 effected the liberation of disulfide and the formation of [tBu(2)P(C(6)F(4))B(donor)(C(6)F(5))(2)]. The reaction of 1 with S(8) gave tBu(2)P(S)(C(6)F(4))B(C(6)F(5))(2) (3). In a similar fashion, the frustrated Lewis pair of tBu(3)P/B(C(6)F(5))(3) reacts with RSSR to give [tBu(3)P(SR)][(RS)B(C(6)F(5))(3)] (R = Ph (4), p-tolyl (5), iPr (6)). In contrast, the corresponding reaction of BnSSBn yields a 1:1:1 mixture of tBu(3)P horizontal lineS, Bn(2)S, and B(C(6)F(5))(3). Species 4 reacts with p-tolylSSp-tolyl to give a mixture of 4, 5, PhSSPh, and p-tolylSS p-tolyl, while treatment of 5 with PhSSPh afforded a similar mixture. To probe this, a crossover experiment between [tBu(3)P(SPh)][B(C(6)F(5))(4)] (7) and [NBu(4)][(p-tolylS)B(C(6)F(5))(3)] (9) was performed. The former species was prepared by a reaction of 4 with [Ph(3)C][B(C(6)F(5)) (4)], while cation exchange of [(Et(2)O)(2)Li( p-tolylS)B(C(6)F(5))(3)] (8) with [NBu(4)]Br gave 9. The reaction of compounds 7 and 9 gave a statistical mixture of the cations [tBu(3)P(SR)](+) and anions [(RS)B(C(6)F(5))(3)](-), R = Ph, Sp-tolyl. The mechanism of this exchange process was probed and is proposed to be an equilibrium involving disulfide and the frustrated Lewis pair. Crystallographic data are reported for compounds 4-8, and the natures of the P-S cations are examined via DFT calculations.
Economics and Market Effects of ETF Short Selling (2010)

This chapter contains sections titled: Understanding the Risks of Selling ETFs Short The Implications of ETF Short Selling ETF Short Selling for Traditional Investors
The Limpopo Magma‐Rich Transform Margin, South Mozambique: 1. Insights From Deep‐Structure Seismic Imaging (2021)

Abstract A variety of structures results from the interplay of evolving far‐field forces, plate kinematics, and magmatic activity during continental break‐up. The east Limpopo transform margin, offshore northern Mozambique, formed as Africa and Antarctica separated during the mid‐Jurassic period break‐up of the Gondwana supercontinent. The nature of the crust onshore has been discussed for decades in an effort to resolve issues with plate kinematic models. Two seismic refraction profiles with coincident multichannel seismic reflection profiles allow us to interpret the seismic velocity structures across the margin, both onshore and offshore. These seismic profiles allow us to (a) delineate the major regional crustal domains; (b) identify widespread indications of magmatic activity; and (c) map crustal structure and geometry of this magma‐rich transform margin. Careful examination of the profiles allows us to make the following observations and interpretations: (a) on land, continental crust is overlain by a &gt;10‐km thick volcano‐sedimentary wedge related to an early rifting stage, (b) offshore, thick oceanic crust formed due to intense magmatic activity, and between the two (c) a 50–60‐km wide transform zone where the crustal structures are affected by intense magmatic activity and faulting. The prominent presence of intrusive and extrusive igneous units may be attributed to the combination of a deep‐seated melting anomaly and a trans‐tensional fault zone running through thinned lithosphere that allowed melt to reach the surface. A comparison of the crustal thinning along other transform margins shows a probable dependence with the thermal and/or tectonic history of the lithosphere.
Spatial-temporal modeling of malware propagation in networks (2005)

Network security is an important task of network management. One threat to network security is malware (malicious software) propagation. One type of malware is called topological scanning that spreads based on topology information. The focus of this work is on modeling the spread of topological malwares, which is important for understanding their potential damages, and for developing countermeasures to protect the network infrastructure. Our model is motivated by probabilistic graphs, which have been widely investigated in machine learning. We first use a graphical representation to abstract the propagation of malwares that employ different scanning methods. We then use a spatial-temporal random process to describe the statistical dependence of malware propagation in arbitrary topologies. As the spatial dependence is particularly difficult to characterize, the problem becomes how to use simple (i.e., biased) models to approximate the spatially dependent process. In particular, we propose the independent model and the Markov model as simple approximations. We conduct both theoretical analysis and extensive simulations on large networks using both real measurements and synthesized topologies to test the performance of the proposed models. Our results show that the independent model can capture temporal dependence and detailed topology information and, thus, outperforms the previous models, whereas the Markov model incorporates a certain spatial dependence and, thus, achieves a greater accuracy in characterizing both transient and equilibrium behaviors of malware propagation.
Weed Science, a Changing Technology (1980)

Slow advances were made in weed technology over 10,000 yr as agriculture progressed from hand weeding to the use of hand tools, animal power, cultural practices, mechanical power, biological controls, and most recently to chemical control.
O2293 THE EFFECT OF DIFFERENT GEOMETRIC CONFIGURATIONS OF THE WEIL OSTEOTOMY ON PLANTAR PRESSURE IN AN IN VITRO CADAVER MODEL (2004)

Aims: To evaluate the effect of different geometric conþgurations of the Weil osteotomy on the plantar pressures in a dynamic in vitro cadaver model. Methods: Ten specimens consisting of 5 matched pairs of cadaver lower extremities were tested. Each pair of specimens had an oblique Weil osteotomy with 5 mm shift performed on one side, and a standard (parallel) Weil osteotomy with 5 mm shift on the other. Then, a 4 mm slice resection, and metatarsal head resection were performed sequentially on each specimen. The plantar pressures were measured while cyclically loaded to 700 N at a frequency of 1 Hz with a F scan in-shoe sensor in intact specimens, and after each intervention. Results: This is the þrst study to demonstrate that the plantar translation of the metatarsal head occurring with a more oblique Weil osteotomy compared to a standard (parallel) Weil osteotomy did not signiþcantly increase plantar pressure in a dynamic in vitro cadaver model. Furthermore, the addition of a 4 mm slice resection did not signiþcantly unload the metatarsal head. Metatarsal head resection was required to signiþcantly unload the metatarsal head (p=0.02). Conclusions: The different geometric conþgurations of the Weil osteotomy did not signiþcantly alter plantar pressures in a dynamic cadaver model. Metatarsal head resection was required to signiþcantly unload the metatarsal head. Future studies of the effect of metatarsal osteotomies on plantar pressure should include evaluation in a dynamic in vitrocadaver model to account for all factors, which determine the distribution of plantar pressure.
Effect of visceral metastases on the efficacy and safety of everolimus in postmenopausal women with advanced breast cancer: Subgroup analysis from the BOLERO-2 study (2013)

Adding EVE to EXE markedly extended PFS by ≥4 months among patients with HR(+) HER2(-) ABC regardless of the presence of visceral metastases.
Role of Peripheral Vision in Brake Reaction Time During Safety Critical Events (2021)

The criticality of a rear end event depends on the brake reaction time (BRT) of the driver. Therefore, distracted driving poses greater threat in such events. Evidence accumulation model (EAM) that uses looming of the lead vehicle as main stimuli has shown significant success in estimating drivers’ BR Ts. It is often argued that drivers collect evidence for braking through peripheral vision, especially during off-road glances, and transition to forward. In this work, we have modeled evidence accumulation as a function of gaze eccentricity for off-road glances while approaching safety critical events. The model is tested with real world crash and near crash event data from SHRP2 naturalistic study. Our model shows that linear relation between gaze eccentricity and evidence accumulation rate during off road glances helps to improve EAM estimation in predicting BRT. We have also shown that brake-light onset does not influence EAM in presence of active looming.
Extremely high aspect ratio GaAs and GaAs/AlGaAs nanowaveguides fabricated using chlorine ICP etching with N2-promoted passivation (2010)

Semiconductor nanowaveguides are the key structure for light-guiding nanophotonics applications. Efficient guiding and confinement of single-mode light in these waveguides require high aspect ratio geometries. In these conditions, sidewall verticality becomes crucial. We fabricated such structures using a top-down process combining electron beam lithography and inductively coupled plasma (ICP) etching of hard masks and GaAs/AlGaAs semiconductors with Al concentrations varying from 0 to 100%. The GaAs/AlGaAs plasma etching was a single-step process using a Cl(2)/BCl(3)/Ar gas mixture with various fractions of N(2). Scanning electron microscope (SEM) observations showed that the presence of nitrogen generated the deposition of a passivation layer, which had a significant effect on sidewall slope. Near-ideal vertical sidewalls were obtained over a very narrow range of N(2), allowing the production of extremely high aspect ratios (>32) for 80 nm wide nanowaveguides.
Measuring pitch and formant frequencies for a speech understanding system (2005)

We present new techniques for the measurement of pitch period and formant frequencies. Individual pitch periods are estimated by finding local maxima in the power spectrum averaged over a frequency band that includes a formant. A spectral analysis is then performed for each pitch period over a data interval that is of shorter duration than the estimated pitch period. The pitch synchronous spectral analysis followed by post detection smoothing - preferably carried out over both time and frequency - leads to a spectrogram from which formant trajectories can be estimated by simple algorithms.
Sundroid (2011)

While the sun is important for our health, overexposure to sunlight carries significant health risks ranging from sunburn to skin cancer. Although people know about these risks, sunlight related skin damages have increased over the past decades. We have conducted a survey that sheds light on this phenomenon and suggests that the missing natural sense for UV radiation negatively influences people's sun related behavior. To address this issue, we have implemented Sundroid. Sundroid measures the incident UV radiation using a body-worn sensing unit that communicates wirelessly with the user's smartphone. The phone thereby acts as a user interface to present the measured data in an intuitive manner, and to notify the user once a critical amount of sunlight has been reached. Sundroid can also be applied in other contexts, such as behavioral research or medicine. We show that after calibration, errors are within 5% compared to a high-precision reference signal.
Eastern Equine Encephalomyelitis: Histopathologic and Ultrastructural Changes with Isolation of the Virus in a Human Case (1975)

Enveloped Toga virus particles were demonstrated by means of an electron microscopy in the brain tissues of a 3-year-old girl with acute encephalitis. Areas of demyelinization and necrosis throughout the white matter and brainstem were revealed by light microscopy. These viral particles were identified as eastern equine encephalomyelitis virus in postmortem isolation of the virus utilizing young mice and complement-fixation studies. To the authors' knowledge, this is the first demonstration of eastern equine encephalomyelitis virus particles in human tissues by electron microscopy.
Imaging Xe with a low-temperature scanning tunneling microscope (1991)

We have obtained images of individual Xe atoms adsorbed on a Ni(110) surface using a low-temperature scanning tunneling microscope (STM). The atom-on-jellium model has been used to calculate the apparent height of a Xe atom as imaged with the STM and the result is found to be in good agreement with experiment. We conclude that the Xe 6s resonance, although lying close to the vacuum level, is the origin of the Fermi-level local state density which renders Xe ``visible'' in the STM.
Evaluation of Defect Distribution in Continuously-Cast Slabs by Using Ultrasonic Defect Detection System and Effect of Electromagnetic Brake on Decreasing Unbalanced Flow in Mold (2015)

In order to clarify the suppression mechanism of an unbalanced flow in the continuous casting mold under high molten steel throughput conditions, the relationship between the unbalanced flow and the distribution of defects entrapped on the solidified shell was measured by ultrasonic defect detection. The relationship between the unbalanced flow and the defect distribution in the mold with an electromagnetic brake was also investigated. The main results are summarized as follows.(1) By using a new ultrasonic defect detection system, accurate measurement of defects was achieved for the defects’ diameter of more than 0.6 mm in the range 2–10 mm from surface.(2) The effect of the electromagnetic brake on decreasing molten steel momentum was measured. The measured value was consistent with the calculated value. Molten steel momentum could be reduced by more than 50% when the Stuart number (N) was more than 3.5 under molten steel throughput conditions of 4.7 and 5.3 ton/min.(3) The position of entrapped defects on the solidified shell in the mold was influenced by the molten steel throughput condition and the magnetic flux density of the electromagnetic brake.
Thermally Stable NiSi2 for Ge Contact with Schottky Barrier Height Modulation Capability (2013)

Agglomeration resistant contact of NiSi 2 with Ge substrates has been performed using stacked silicidation process. Stable Schottky barrier height at NiSi 2 /Ge interface with ideality factor of less than 1.2 can be maintained up to annealing temperature of 500 o C. Incorporation of P atom at NiSi 2 /Ge interface modulates the Schottky barrier height to produce Ohmic contact.
A new visit to an old problem in switched-capacitor converters (2010)

The energy-efficiency issue of the switched-capacitor converters is still a highly controversial topic that requires a more in-depth exploration. This paper will address the issue by dissecting the analysis of the entire efficiency problem into two parts. In the first part, the efficiency analysis of charging the capacitor of an RC circuit under different aspects (partial charging, full charging, at zero capacitor voltage, at non-zero capacitor voltage, etc.) will be conducted. In the second part, the efficiency analysis of discharging the capacitor of an RC circuit with resistive and capacitive loads will be covered. A complete evaluation of the overall efficiency is then performed in terms of both the charging and discharging efficiencies of the capacitor. Additionally, it is shown in this paper that the claim that quasi-switched-capacitor converters are more lossy than switched-capacitor converters is a common misconception.
Modeling Lake-Chemistry Distributions: Approximate Bayesian Methods for Estimating a Finite-Mixture Model (1992)

A modification of the Laplace method is presented and applied to estimation of posterior functions in a Bayesian analysis of finite-mixture distributions. The technique is nonsequential yet relatively fast and provides estimates of mixture-model parameters and classification probabilities. The method is applied to a regional distribution of lake-chemistry data for north central Wisconsin. A mixture density of two lognormal populations is estimated for the acid-neutralizing capacity of lakes in the region, using several other lake characteristics as explanatory variables for classification into lake subpopulations. The fitted mixture model provides a good representation of the observed distribution. Separation into subpopulations based solely on the other lake characteristics matches the mixture-model classification relatively well.
Evaluation of the immunomodulatory effects of 1-Phenylnaphthalene and Pericarbonyl lactone lignan compounds (2012)

Throughout history, natural products have afforded a rich source of compounds that have found many applications in the fields of medicine, pharmacy and biology. Within the sphere of immunomodulation, a number of important new commercialized drugs have been obtained from natural sources, by structural modification of natural compounds or by the synthesis of new compounds, designed following a natural compound as model. To search for improved immunomodulators, 1-Phenylnaphthalene and Pericarbonyl lactone lignans and their synthetic derivatives were tested for the immunomodulatory activity by the assay of Spleen cell proliferation. The investigation found that the naturally occurring and related synthetic organic compounds with 1-Phenylnaphthalene and Pericarbonyl lactone systems were potent in producing immune stimulation. In HIV treatment, they can assist the immune system in driving out the HIV virus and are expected to lower the incidence of opportunistic infections in several immunodeficiencies.
Supplementary Tables from SGN-CD228A Is an Investigational CD228-Directed Antibody–Drug Conjugate with Potent Antitumor Activity across a Wide Spectrum of Preclinical Solid Tumor Models (2023)

&lt;p&gt;Tables S1-S4&lt;/p&gt;
Normothermic Ex-vivo Kidney Perfusion in a Porcine Auto-Transplantation Model Preserves the Expression of Key Mitochondrial Proteins: An Unbiased Proteomics Analysis (2021)

Normothermic ex-vivo kidney perfusion (NEVKP) results in significantly improved graft function in porcine auto-transplant models of donation after circulatory death injury compared with static cold storage (SCS); however, the molecular mechanisms underlying these beneficial effects remain unclear. We performed an unbiased proteomics analysis of 28 kidney biopsies obtained at three time points from pig kidneys subjected to 30 min of warm ischemia, followed by 8 h of NEVKP or SCS, and auto-transplantation. 70/6593 proteins quantified were differentially expressed between NEVKP and SCS groups (false discovery rate < 0.05). Proteins increased in NEVKP mediated key metabolic processes including fatty acid ß-oxidation, the tricarboxylic acid cycle, and oxidative phosphorylation. Comparison of our findings with external datasets of ischemia-reperfusion and other models of kidney injury confirmed that 47 of our proteins represent a common signature of kidney injury reversed or attenuated by NEVKP. We validated key metabolic proteins (electron transfer flavoprotein subunit beta and carnitine O-palmitoyltransferase 2, mitochondrial) by immunoblotting. Transcription factor databases identified members of the peroxisome proliferator-activated receptors (PPAR) family of transcription factors as the upstream regulators of our dataset, and we confirmed increased expression of PPARA, PPARD, and RXRA in NEVKP with reverse transcription polymerase chain reaction. The proteome-level changes observed in NEVKP mediate critical metabolic pathways. These effects may be coordinated by PPAR-family transcription factors and may represent novel therapeutic targets in ischemia-reperfusion injury.
Crystal Structures and Vibrational Spectroscopy of Copper(I) Thiourea Complexes (2008)

Several synthetic strategies using copper(I) starting materials or copper(II) compounds and an in situ sulfite reductant have been used to systematically explore the chemistry of copper(I) complexes with thiourea and substituted thiourea ligands. This has resulted in the discovery of several new complexes and methods for the bulk synthesis of some previously reported complexes that had been prepared adventitiously in small quantity. The new complexes are (tu = thiourea, dmtu = N,N'-dimethylthiourea, etu = ethylenethiourea): [I(4)Cu(4)(tu)(6)].H(2)O, [Cu(4)(tu)(10)](NO(3)).tu.3H(2)O, [BrCu(dmtu)(3)], [ICu(dmtu)(3)](2), [BrCu(etu)(2)](2), [ICu(etu)(2)], [ICu(etu)(2)](3). [I(4)Cu(4)(tu)(6)].H(2)O has an adamantanoid structure, with four terminal iodide ligands and six doubly bridging tu ligands. In contrast to this, [Cu(4)(tu)(10)](NO(3)).tu.3H(2)O contains a tetranuclear cluster in which four of the tu ligands are terminal and the other six are doubly bridging. [BrCu(dmtu)(3)] is a mononuclear complex with tetrahedral coordination of copper by one bromide and three dmtu ligands, whereas [Cu(dmtu)(3)](2)I(2) has a centrosymmetric dimeric cation with two uncoordinated iodides, four terminal dmtu and two doubly bridging dmtu ligands, [(dmtu)(2)Cu(mu-S-dmtu)(2)Cu(dmtu)(2)]I(2). A reversal of this monomer to dimer trend from bromide to iodide is seen for the etu counterparts: [BrCu(etu)(2)](2) is a centrosymmetric dimer with two doubly bridging etu ligands, [(etu)BrCu(mu-S-etu)(2)CuBr(etu)], whereas [ICu(etu)(2)] is a trigonal planar monomer, although the novel [I(3)Cu(3)(etu)(6)] is also defined. Infrared and Raman spectra of the synthesized complexes were recorded and the metal-ligand vibrational frequencies have been assigned in many cases. The results confirm previously observed correlations between the vibrational frequencies and the corresponding bond lengths for complexes of the unsubstituted tu ligand. A mechanochemical/infrared method was used to synthesize [I(3)Cu(3)(etu)(6)] from CuI and etu, and to demonstrate the polymorphic transition from [ICu(etu)(2)] to [I(3)Cu(3)(etu)(6)].
Bacterial Growth in Chloride and Perchlorate Brines: Halotolerances and Salt Stress Responses of Planococcus halocryophilus (2019)

Extraterrestrial environments encompass physicochemical conditions and habitats that are unknown on Earth, such as perchlorate-rich brines that can be at least temporarily stable on the martian surface. To better understand the potential for life in these cold briny environments, we determined the maximum salt concentrations suitable for growth (MSCg) of six different chloride and perchlorate salts at 25°C and 4°C for the extremotolerant cold- and salt-adapted bacterial strain <i>Planococcus halocryophilus</i>. Growth was measured through colony-forming unit (CFU) counts, while cellular and colonial phenotypic stress responses were observed through visible light, fluorescence, and scanning electron microscopy. Our data show the following: (1) The tolerance to high salt concentrations can be increased through a stepwise inoculation toward higher concentrations. (2) Ion-specific factors are more relevant for the growth limitation of <i>P. halocryophilus</i> in saline solutions than single physicochemical parameters like ionic strength or water activity. (3) <i>P. halocryophilus</i> shows the highest microbial sodium perchlorate tolerance described so far. However, (4) MSCg values are higher for all chlorides compared to perchlorates. (5) The MSCg for calcium chloride was increased by lowering the temperature from 25°C to 4°C, while sodium- and magnesium-containing salts can be tolerated at 25°C to higher concentrations than at 4°C. (6) Depending on salt type and concentration, <i>P. halocryophilus</i> cells show distinct phenotypic stress responses such as novel types of colony morphology on agar plates and biofilm-like cell clustering, encrustation, and development of intercellular nanofilaments. This study, taken in context with previous work on the survival of extremophiles in Mars-like environments, suggests that high-concentrated perchlorate brines on Mars might not be habitable to any present organism on Earth, but extremophilic microorganisms might be able to evolve thriving in such environments.