gebhart/patrepeval huggingface dataset:
Step Activity After Surgical Treatment of Ankle Arthritis (2018)

Category: Ankle Arthritis Introduction/Purpose: We used step counts as objective measures of activity as a compliment to patient self-reported outcomes in treatment of ankle arthritis to validate success or failure of treatment. Methods: 234 patients who were treated with ankle arthrodesis or ankle replacement wore step activity monitors before treatment and after treatment at 6 months, 12 months, 24 months and 36 months. Total steps taken as well as low, medium and high activity, sustained activity, and an activity index were measured in each group. In addition, step activity was compared with the subjects’ self-reported outcome using the MFA and SF-36. We measured change from baseline and compared treatment type. Linear mixed-effects regression analysis was used to test for improvement in step activity (the dependent variables) across follow-up (the fixed effect, modeled as 4 dummy variables representing differences from pre-op at 6, 12, 24 and 36 months), with fixed covariates age, sex, body mass index (BMI) and surgical treatment. Results: Both treatment groups improved significantly. Objective and PROM were not parallel. While PROM plateaued at 6 months, steps continued to increase at 36 months. Step counts increases did correlate with improving PROM however. Patients undergoing arthrodesis had slower improvement than arthroplasty patients with greater differences in the early stages of recovery (i.e., 6 and 12-month post-op) than at 36 months where improvements were similar across groups. (See table 2 for data). The trajectory of recovery was different but there were no significant differences in improvement by surgery procedure. Conclusion: Patients increase the number and the intensity of steps after treatment. Improvement after arthrodesis and ankle replacement follow different trajectories. For step totals, high intensity steps and the sustained activity metrics, arthroplasty patients showed more improvement than arthrodesis patients early in recovery. Step data are consistent with patient reported outcomes but do not parallel them. Unlike PROM which improve dramatically in the first six months then plateau, step activity demonstrated mild or no improvement at 6 months but later had improvement that increased gradually across follow-up out to three years. Objective outcome measures add value to measurement of treatment outcomes.
MM-TTA: Multi-Modal Test-Time Adaptation for 3D Semantic Segmentation (2022)

Test-time adaptation approaches have recently emerged as a practical solution for handling domain shift without access to the source domain data. In this paper, we propose and explore a new multi-modal extension of test-time adaptation for 3D semantic segmentation. We find that directly applying existing methods usually results in performance instability at test time because multi-modal input is not considered jointly. To design a framework that can take full advantage of multi-modality, where each modality provides regularized self-supervisory signals to other modalities, we propose two complementary modules within and across the modalities. First, Intra-modal Pseudolabel Generation (Intra-PG) is introduced to obtain reliable pseudo labels within each modality by aggregating information from two models that are both pre-trained on source data but updated with target data at different paces. Second, Inter-modal Pseudo-label Refinement (Inter-PR) adaptively selects more reliable pseudo labels from different modalities based on a proposed consistency scheme. Experiments demonstrate that our regularized pseudo labels produce stable self-learning signals in numerous multi-modal test-time adaptation scenarios for 3D semantic segmentation. Visit our project website at https://www.nec-labs.com/~mas/MM-TTA.
10-W pulsed operation of substrate emitting photonic-crystal quantum cascade laser with very small divergence (2015)

High-power broad area substrate emitting photonic-crystal distributed feedback (DFB) quantum cascade lasers (QCLs) emitting around 4.73 μm is reported. Two-dimensional centered rectangular photonic-crystal (CRPC) grating is introduced to enhance optical coherence in large area device. Main lobe far-field radiation pattern with a very small divergence angle of about 0.65° × 0.31° is obtained. A record peak output power for vertical emitting QCLs exceeding 10 W is obtained with high reflectivity (HR) coating. Robust single longitudinal mode emission with a side mode suppression ratio (SMSR) of 30 dB is continuously tunable by the heat sink temperature up to 65°C.
Nonlinear Analysis of Onset of Nucleate Boiling in Natural Circulation under Different Pressure Conditions (2013)

In this study, we obtain the flow signals before and after the ONB through natural circulation experiments under pressure conditions of 0.15MPa and 0.3MPa. Researches were conducted by applying nonlinear analysis techniques. Results revealed that the power spectrum of volume flow data declined exponentially over time in semi logarithmic coordinates, the autocorrelation coefficient declined gradually and the phase diagram exerted the subtle structures of chaotic movement, which might prove the existence of chaos in natural circulation system. The natural convection of single phase appeared before the occurrence of ONB belonged to a non equilibrium process which showed remarkable random features. The occurrence of ONB was a process containing the beginning of chaotic motion and the continuing occurrence of bubbles at ONB and the tendency of phase change to become nucleation boiling would achieve certain states, which embodied the characteristics of chaos. In addition, the intense density difference environment of natural circulation could accelerate the occurrences of both chaotic motion and ONB. While the density difference of heated liquid decreased with the increase of pressure, which could delay the occurrence of ONB.
A multi-sensor approach and ranking analysis procedure for oil seeps detection in marine environments (2007)

Accidents involving oil spills from petroleum exploration, production, and transportation facilities have stained the history of major companies. The implementation of monitoring systems as an aid to contingency planning is crucial to guarantee proper environmental performance in offshore activities. On the other hand, natural oil and gas seeps have historically provided invaluable information to oil explorers in frontier areas. The use of Synthetic Aperture Radar (SAR) orbital systems is commonly used for oil slicks detection in the marine environment. Such information can be applied to petroleum exploration (oil seeps detection) and environmental assessment (oil spills monitoring). In combination with SAR satellite images (RADARSAT-1 and ENVISAT ASAR), and essential meteorological and oceanographic data, the proposed technology enhances the detection of oil slicks in the ocean surface based on radar texture.
Synthesis and Spectral Properties of Fluorescent Dithienylmaleimides (2006)

Abstract A convenient preparative method of the synthesis of dithienylethenes based on maleimides was proposed. Previously, difficult accessible dithienylethene derivatives, in which 2-thienyl substituents are attached to the double bond of maleimide, have been synthesized. The spectral properties of the dithienylmaleimides were studied and it has been shown that these compounds do not belong to photochromes but they possess fluorescent properties.
Inhibition of Adult Neurogenesis by Inducible and Targeted Deletion of ERK5 Mitogen-Activated Protein Kinase Specifically in Adult Neurogenic Regions Impairs Contextual Fear Extinction and Remote Fear Memory (2012)

Although there is evidence suggesting that adult neurogenesis may contribute to hippocampus-dependent memory, signaling mechanisms responsible for adult hippocampal neurogenesis are not well characterized. Here we report that ERK5 mitogen-activated protein kinase is specifically expressed in the neurogenic regions of the adult mouse brain. The inducible and conditional knock-out (icKO) of erk5 specifically in neural progenitors of the adult mouse brain attenuated adult hippocampal neurogenesis. It also caused deficits in several forms of hippocampus-dependent memory, including contextual fear conditioning generated by a weak footshock. The ERK5 icKO mice were also deficient in contextual fear extinction and reversal of Morris water maze spatial learning and memory, suggesting that adult neurogenesis plays an important role in hippocampus-dependent learning flexibility. Furthermore, our data suggest a critical role for ERK5-mediated adult neurogenesis in pattern separation, a form of dentate gyrus-dependent spatial learning and memory. Moreover, ERK5 icKO mice have no memory 21 d after training in the passive avoidance test, suggesting a pivotal role for adult hippocampal neurogenesis in the expression of remote memory. Together, our results implicate ERK5 as a novel signaling molecule regulating adult neurogenesis and provide strong evidence that adult neurogenesis is critical for several forms of hippocampus-dependent memory formation, including fear extinction, and for the expression of remote memory.
Economic feasibility of residential behind-the-meter battery energy storage under energy time-of-use and demand charge rates (2017)

In this paper, the economic viability of using behind-the-meter battery energy storage (BMBES) for time-of-use (ToU) energy arbitrage and demand charge (DC) reduction is compared. The study focuses on residential applications where the BMBES is installed at end-users premises and used for daily cycling under ToU and DC plans for saving on monthly electricity bills. Under the current U.S. electricity prices, different case studies of using two BMBES systems are discussed. The two systems are analyzed with practical load profiles of a two-story American family house. A number of ToU and DC plans from different utility companies and with different pricing structures are applied. First, the mathematical formulation of the monthly savings in the electricity bill is presented to determine the different technical and economic factors that affect the savings. Then, the System Advisor Model (SAM) software tool, which provides a techno-economic model of battery storage systems, is used for hourly, monthly, and annual analysis. In each scenario, the economic performance of the BMBES systems in terms of the cash flow diagram, net present worth and payback period is presented and discussed. Based on the analysis results, a set of implications on the profitability of the ToU energy arbitrage and DC reduction schemes under current prices of energy storage and electricity rates are stated. Such implications can be beneficial to customers and practitioners for selecting and designing residential electric rates.
Case report: Variable response to immunotherapy in ovarian cancer: Our experience within the current state of the art (2022)

Despite recent advances in ovarian cancer (OC) treatment, including the introduction of bevacizumab and PARP-inhibitors, OC remains a lethal disease. Other therapeutic options are being explored, such as immunotherapy (IT), which has been proved effective in many solid tumors. Findings about tumor-infiltrating cytotoxic and regulatory T cells, together with the expression of PD-1 on immune cells and of PD-L1 on tumor cells, gave the rationale for an attempt to the use of IT also in OC. We treated two patients with avelumab, an anti-PD-L1 monoclonal antibody, after the first line of chemotherapy: Patient A underwent 19 cycles of maintenance therapy with avelumab with a disease-free interval of 12 months, whereas patient B showed a slight progression of disease after only eight cycles. A higher PD-L1 expression in tumor cells of patient A was detected. She also underwent a genomic assessment that described the presence of a high Tumor Mutational Burden (TMB) and a status of Loss of Heterozygosity (LoH). This different response to the same treatment puts in evidence that some genomic and immune features might be investigated.
Molecular structures of the dihydrodiols and diol epoxides of carcinogenic polycyclic aromatic hydrocarbons. X-ray crystallographic and NMR analysis (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular structures of the dihydrodiols and diol epoxides of carcinogenic polycyclic aromatic hydrocarbons. X-ray crystallographic and NMR analysisD. E. Zacharias, J. P. Glusker, P. P. Fu, and R. G. HarveyCite this: J. Am. Chem. Soc. 1979, 101, 15, 4043–4051Publication Date (Print):July 1, 1979Publication History Published online1 May 2002Published inissue 1 July 1979https://pubs.acs.org/doi/10.1021/ja00509a004https://doi.org/10.1021/ja00509a004research-articleACS PublicationsRequest reuse permissionsArticle Views79Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Quantitative assessment of liver function using hepatobiliary scintigraphy (2019)

After PVE, the nonembolized lobe had a significantly higher (functional) microvascular density compared with the embolized lobe, without differences in microvascular flow. These findings indicate that the measured functional increase using hepatobiliary scintigraphy, which exceeded the volumetric increase, was not the consequence of an increase in hepatic perfusion, therefore, providing adequate representation of the liver function.
Hierarchical Stereo Matching Via Color Segmentation (2006)

This paper presents a new segment-based stereo matching algorithm using a coarse-to-fine multiresolution strategy. In general, the multiresolution scheme was employed in a direct descending optimization to avoid matching in the local minimal. However, it is not effective in homogeneously textured regions and disparity discontinuous boundaries. We implement a novel hierarchical segment-based matching scheme to produce accurate disparity maps, which resolves the above mentioned challenging problems. We utilize the hierarchical color segmentation that is classified in each resolution level to guide the matching process gradually. The principal feature of our scheme is to combine the local and the global optimization in multiresolution stages. To validate the proposed algorithm, we show the experimental results on the new Middlebury database sets
Präzision bis in den Sub-µm-Bereich (2021)

Im Bereich Formen- und Werkzeugbau werden die Anforderungen an Genauigkeit und Oberflächenqualität ständig verschärft. Beispiele sind Spaltmaßvorgaben im 1-µm-Bereich bei Stanzwerkzeugen oder Formen für Smartphone-Linsen. Deshalb steigt auch der Anteil an Jobs mit einer Finishbearbeitung durch Koordinatenschleifen.
Iron increases busulfan toxicity in vivo and in vitro (2007)

1565 Busulfan is an alkylating agent widely used in combination high-dose chemotherapy regimens followed by allogeneic or autologous haematopoietic stem cell transplantation (HSCT). The effect of iron on busulfan toxicity was investigated since we proposed that iron-generated pro-oxidant state may explain busulfan toxicity during HSCT. Toxicology and metabolism of busulfan (16.5 mg/kg bid over four days) combined with melphalan (20 mg/kg) and syngeneic bone marrow transplantation (BMT) were investigated in iron overloaded mice (C57Bl6 male). Mice were supplemented during one month with a special diet with Renutryl® in which were added high concentrations of FeSO4 (almost 500 fold the content in the control diet). Iron overload was evidenced by histology in the liver of supplemented mice compared to control animals. Liver accumulation was associated with a significant increase in plasma concentrations from 19 ± 4 µM to 39 ± 4 µM. No difference was observed in busulfan plasma clearance in between control animals and supplemented animals. However in both cases, a significant induction of clearance through the glutathione pathway during repeated injections was observed. In spite of equivalent busulfan exposure, we observed a dramatic increase of the toxicity after a combined treatment with busulfan and melphalan in iron supplemented mice with a median survival of 2 days after BMT. We have shown previously that busulfan metabolism through the glutathione pathway induces an increase of cysteine liver content in order to sustain glutathione levels. Consequently iron may be reduced from the ferric to the ferrous form. This latter is known to be responsible of the pro-oxidant state through the Fenton reaction. This hypothesis was investigated in vitro. Prior cell cycle analyses have shown the time-dependent toxicity of busulfan. These investigations allowed to define optimal conditions to investigate busulfan toxicity in vitro against two cell lines; IGR-N91, a cell line derived from a neuroblastoma and HepG2, a cell line derived from an hepatocarcinoma. Busulfan was combined with iron and cysteine and the cytotoxicity was investigated after one week of treatment with the MTT assay. In vitro experiments have shown that iron enhanced significantly the cytotoxicity of busulfan. This enhancement of busulfan cytoxicity was maximal when iron (1 mM) was combined with cysteine (2 mM) to favour the pro-oxidant ferrous state. In these conditions, the CI50 of busulfan decreased from 15.5 ± 4.2 µM to 4.8 ± 1.1 µM in IGR-N91 and from 21.7 ± 7.2 µM to 13.0 ± 0.9 µM in Hep-G2. In conclusion, iron increases busulfan toxicity. Mechanisms need to be elucidated, especially through the investigation of the metabolism of busulfan by the glutathione/glutathione S-transferase pathway.
Optical Parameters of Leaves of 30 Plant Species (1973)

Optical parameters (absorption coefficient k, infinite reflectance Rinfinity, scattering coefficient 8) are tabulated for seven wavelengths and analyzed for statistical differences for 30 plant species. The wavelengths are: 550 nm (green reflectance peak), 650 nm (chlorophyll absorption band), 850 nm (infrared reflectance plateau), 1450 nm (water absorption band), 1650 nm (reflectance peak following water absorption band at 1450 nm), 1950 nm (water absorption band), and 2200 nm (reflectance peak following water absorption band at 1950 nm).Thick, complex dorsiventral (bifacial mesophyll) leaves such as rubber plant, begonia, sedum, and privet had lower Rinfinity values than thinner, less complex dorsiventral leaves (i.e., soybean, peach, bean, rose) or essentially centric (undifferentiated mesophyll) sorghum and corn leaves. Infinite reflectance was negatively correlated with leaf thickness (-0.734(**)).Thick, complex dorsiventral leaves (crinum, oleander, privet, rubber plant, sedum) had higher (p 0.01) k values than thinner, less complex dorsiventral leaves (i.e., soybean, rose, peach) or essentially centric sorghum, sugarcane, and corn leaves. A coefficient of 0.718(**) was obtained for the correlation of k values with leaf thickness values.Complex dorsiventral oleander, orange, and crinum leaves had higher (p 0.01) 8 values than less complex dorsiventral (i.e., onion, begonia, banana) or centric leaves (i.e., corn and sugarcane). The scattering coefficient was not correlated with leaf thickness.
Abstract 4423: MiR551b-mediated Oncostatin M signaling in breast cancer (2018)

Abstract We have previously demonstrated that an oncogenic microRNA miR551b-3p (also known as miR551b) regulates STAT3 transcription thereby enhancing tumor growth and metastasis in ovarian cancer. Herein, we have identified that Oncostatin M (OSM) is upregulated through STAT3-driven transcription, which plays an important role in promoting migration and invasion of breast cancer cells. The purpose of this study was to evaluate the role of miR551b mediated STAT3 activation and the precise mechanism that regulates OSM-Receptor (OSMR) signaling for breast cancer growth and metastasis. MDA-MB231 cells were either overexpressed or silenced with miR551b and anti-miR551b respectively and the effects on proliferation, migration/invasion (Matrigel transwell assay), wound healing and expression of OSMR and its downstream targets (Western blotting, Quantitative RT-PCR) were assessed. Our data demonstrate that miR551b promoted survival, proliferation, invasion and migration and epithelial to mesenchymal transition (EMT) and spheroid formation of breast cancer cells. Our results also show that miR551b-mediated STAT3 activation upregulated the components of OSMR signaling through elevated expression of OSMR, Interleukin 31 receptor-alpha (IL31RA) and their ligands Oncostatin (OSM) and IL31 thereby inducing phosphorylation of STAT3 for tumor cell proliferation, migration and invasion. Conversely, anti-miR551b reduced the expression of OSMR, IL31R and their ligands OSM and IL31 as well as the phosphorylation of STAT3. Briefly, our results provide the first report indicating that miR551b regulates OSMR expression by activating STAT3 and thereby promoting tumor cell growth and metastasis in breast cancer cells through autocrine feed-forward signaling loop. A.G, D.P., contributed equally. Citation Format: Anjali Geethadevi, Deepak Parashar, Miriam Ragle-Aure, Bindu Nair, Yiling Lu, Vessela N. Kristensen, Ming You, Anil K. Sood, Gordon B. Mills, Sunila Pradeep, Pradeep Chaluvally Raghavan. MiR551b-mediated Oncostatin M signaling in breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 4423.
Head and neck cancer patient images for determining auto‐segmentation accuracy in T2‐weighted magnetic resonance imaging through expert manual segmentations (2020)

This dataset provides head and neck patient MRI scans to evaluate auto-segmentation systems on T2-weighted images. Additional anatomies could be provided at a later time to enhance the existing library of contours.
Pregnancy and melanoma: a European‐wide survey to assess current management and a critical literature overview (2016)

The management of melanoma during pregnancy varies widely in Europe. At present, there is a lack of consensus in Europe, which may lead to very important decisions in women with melanoma, and guidelines are needed.
Synthesis and structural characterisation of the first tris(diacylpnictido)phosphines, P[E{C(O)R}2]3, E = P or As, R = But or Ph (2002)

The reactions of the 2-phospha- or 2-arsa-dionatolithium complexes, [Li(DME){η2-O,O-OC(R)EC(R)}], E = P or As, R = But or Ph, with PCl3 have afforded the first examples of tris(diacylpnictido)phosphines, P[E{C(O)R}2]3, two of which have been structurally characterised.
ChemInform Abstract: Synthesis of Brevetoxin Sub‐Units by Sequential Ring‐Closing Metathesis and Hydroboration. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.