gebhart/patrepeval huggingface dataset:
On the mechanism of the mediolateral gradient of parasternal activation (1996)

Recent studies have shown that in spontaneously breathing dogs the parasternal intercostals are activated according to a mediolateral gradient. To assess the mechanism of this regionalization of activity, we assessed the pattern of activation of these muscles after section of the dorsal roots and examined the topographic distribution of the muscle fiber types from the sternum to the chondrocostal junctions. The pattern of parasternal activity after dorsal rhizotomy was similar in all respects to that previously observed in intact animals. Thus activity in the medial parasternal bundles at the onset of inspiration frequently preceded activity in the middle bundles, and no activity was recorded from the lateral bundles. The amount of medial activity, when expressed as a percentage of the activity recorded during supramaximal tetanic stimulation of the internal intercostal nerve (maximal activity), was also consistently greater than the amount of middle activity (52.6 +/- 4.6 vs. 23.1 +/- 2.6% maximal activity; P < 0.001). Furthermore, the medial, middle, and lateral parasternal bundles had a higher proportion of slow-twitch oxidative fibers than of fast-twitch oxidative-glycolytic fibers; no topographic difference in fiber type distribution was observed. We conclude, therefore, that the mediolateral gradient of parasternal activity is probably due to the unequal distribution of central inputs throughout the pool of alpha-motoneurons.
NogoR1 and PirB Signaling Stimulates Neural Stem Cell Survival and Proliferation (2014)

Neural stem cells (NSCs) and neural progenitors (NPs) in the mammalian neocortex give rise to the main cell types of the nervous system. The biological behavior of these NSCs and NPs is regulated by extracellular niche derived autocrine-paracrine signaling factors on a developmental timeline. Our previous reports [Plos One 2010;5:e15341; J Neurochem 2011;117:565-578] have shown that chondroitin sulfate proteoglycan and ApolipoproteinE are autocrine-paracrine survival factors for NSCs. NogoA, a myelin related protein, is expressed in the cortical ventricular zones where NSCs reside. However, the functional role of Nogo signaling proteins in NSC behavior is not completely understood. In this study, we show that NogoA receptors, NogoR1 and PirB, are expressed in the ventricular zone where NSCs reside between E10.5 and 14.5 but not at E15.5. Nogo ligands stimulate NSC survival and proliferation in a dosage-dependent manner in vitro. NogoR1 and PirB are low and high affinity Nogo receptors, respectively and are responsible for the effects of Nogo ligands on NSC behavior. Inhibition of autocrine-paracrine Nogo signaling blocks NSC survival and proliferation. In NSCs, NogoR1 functions through Rho whereas PirB uses Shp1/2 signaling pathways to control NSC behavior. Taken together, this work suggests that Nogo signaling is an important pathway for survival of NSCs.
HIV-1 Tat Interaction with RNA Polymerase II C-terminal Domain (CTD) and a Dynamic Association with CDK2 Induce CTD Phosphorylation and Transcription from HIV-1 Promoter (2002)

Human immunodeficiency virus, type 1 (HIV-1), Tat protein activates viral gene expression through promoting transcriptional elongation by RNA polymerase II (RNAPII). In this process Tat enhances phosphorylation of the C-terminal domain (CTD) of RNAPII by activating cell cycle-dependent kinases (CDKs) associated with general transcription factors of the promoter complex, specifically CDK7 and CDK9. We reported a Tat-associated T-cell-derived kinase, which contained CDK2. Here, we provide further evidence that CDK2 is involved in Tat-mediated CTD phosphorylation and in HIV-1 transcription in vitro. Tat-mediated CTD phosphorylation by CDK2 required cysteine 22 in the activation domain of Tat and amino acids 42-72 of Tat. CDK2 phosphorylated Tat itself, apparently by forming dynamic contacts with amino acids 15-24 and 36-49 of Tat. Also, amino acids 24-36 and 45-72 of Tat interacted with CTD. CDK2 associated with RNAPII and was found in elongation complexes assembled on HIV-1 long-terminal repeat template. Recombinant CDK2/cyclin E stimulated Tat-dependent HIV-1 transcription in reconstituted transcription assay. Immunodepletion of CDK2/cyclin E in HeLa nuclear extract blocked Tat-dependent transcription. We suggest that CDK2 is part of a transcription complex that is required for Tat-dependent transcription and that interaction of Tat with CTD and a dynamic association of Tat with CDK2/cyclin E stimulated CTD phosphorylation by CDK2.
Cable insulation density profile determined from ultrasonic velocity measurements (1992)

Density results obtained on the same cable sample with a column and from ultrasonic measurements are reported. A calibration curve relating ultrasonic velocity and cable insulation density is given for PE and crosslinked PE (XLPE) cables. The limits and advantages of deducing density profiles of cable insulation using a focused, ultrasound beam rather than the more time-consuming column measurements are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The inhibition of adenylate cyclase in equine platelets by collagen and by platelet-activating factor (1996)

Equine platelet aggregation was stimulated by collagen fibres or platelet-activating factor. The action of both ligands was blocked by forskolin or prostaglandin E(1) agents which are known to activate adenylate cyclase. Equine platelet membranes were found to contain adenylate cyclase activity which was inhibited in dose-dependent fashion by both collagen and platelet-activating factor. Platelet-activating factor-induced inhibition was antagonised by WEB2086.
X-Vectors: Robust DNN Embeddings for Speaker Recognition (2018)

In this paper, we use data augmentation to improve performance of deep neural network (DNN) embeddings for speaker recognition. The DNN, which is trained to discriminate between speakers, maps variable-length utterances to fixed-dimensional embeddings that we call x-vectors. Prior studies have found that embeddings leverage large-scale training datasets better than i-vectors. However, it can be challenging to collect substantial quantities of labeled data for training. We use data augmentation, consisting of added noise and reverberation, as an inexpensive method to multiply the amount of training data and improve robustness. The x-vectors are compared with i-vector baselines on Speakers in the Wild and NIST SRE 2016 Cantonese. We find that while augmentation is beneficial in the PLDA classifier, it is not helpful in the i-vector extractor. However, the x-vector DNN effectively exploits data augmentation, due to its supervised training. As a result, the x-vectors achieve superior performance on the evaluation datasets.
Cascading map-side joins over HBase for scalable join processing (2012)

One of the major challenges in large-scale data processing with MapReduce is the smart computation of joins. Since Semantic Web datasets published in RDF have increased rapidly over the last few years, scalable join techniques become an important issue for SPARQL query processing as well. In this paper, we introduce the Map-Side Index Nested Loop Join (MAPSIN join) which combines scalable indexing capabilities of NoSQL storage systems like HBase, that suffer from an insufficient distributed processing layer, with MapReduce, which in turn does not provide appropriate storage structures for efficient large-scale join processing. While retaining the flexibility of commonly used reduce-side joins, we leverage the effectiveness of map-side joins without any changes to the underlying framework. We demonstrate the significant benefits of MAPSIN joins for the processing of SPARQL basic graph patterns on large RDF datasets by an evaluation with the LUBM and SP2Bench benchmarks. For most queries, MAPSIN join based query execution outperforms reduce-side join based execution by an order of magnitude.
Update on Intravenous Immunoglobulins (IVIg) Mechanisms of Action and Off- Label use in Autoimmune Diseases (2011)

Intravenous Immunoglobulins (IVIg) are administered both as replacement therapy for certain immunodeficiencies and as immunomodulatory therapy for some autoimmune diseases. While the treatment with IVIg is approved in only a few autoimmune diseases, the number of off-label indications is increasing. The varied mechanisms by which IVIg attains its beneficial effect are diverse. There is much evidence for the beneficial and safety profile for IVIg in low as well as high-dose protocols. Patients prone to develop thrombotic events should be advised about the risk of IVIg therapy especially at high doses. This paper updates the mechanisms of action of IVIg as well as recent off-label indications.
Handling Network Partitions and Mergers in Structured Overlay Networks (2007)

Structured overlay networks form a major class of peer- to-peer systems, which are touted for their abilities to scale, tolerate failures, and self-manage. Any long-lived Internet-scale distributed system is destined to face network partitions. Although the problem of network partitions and mergers is highly related to fault-tolerance and self-management in large-scale systems, it has hardly been studied in the context of structured peer-to-peer systems. These systems have mainly been studied under churn (frequent joins/failures), which as a side effect solves the problem of network partitions, as it is similar to massive node failures. Yet, the crucial aspect of network mergers has been ignored. In fact, it has been claimed that ring-based structured overlay networks, which constitute the majority of the structured overlays, are intrinsically ill-suited for merging rings. In this paper, we present an algorithm for merging multiple similar ring-based overlays when the underlying network merges. We examine the solution in dynamic conditions, showing how our solution is resilient to churn dur- ng the merger, something widely believed to be difficult or mpossible. We evaluate the algorithm for various scenar- os and show that even when falsely detecting a merger, the algorithm quickly terminates and does not clutter the network with many messages. The algorithm is flexible as the tradeoff between message complexity and time complexity can be adjusted by a parameter.
Thin Copper Flakes for Conductive Inks Prepared by Decomposition of Copper Formate and Ultrafine Wet Milling (2018)

Abstract Fabrication of devices by printing conductive interconnections on plastic substrates is of growing interest. Currently, silver flakes are wildly used, however the high cost of silver prevents their wide use in many electrical devices. A new two‐step process for synthesizing thin copper flakes, and their utilization in conductive inks, is reported. In the first step, sub‐micrometer copper particles are formed by thermal decomposition and self‐reduction of copper formate. These copper particles are then milled in a wet bead mill that results in their transformation into thin flakes with an average thickness of 48 nm. X‐ray diffraction results indicate that the copper particles undergo plastic deformation in a mechanism similar to cold rolling. The effect of various process parameters and type of dispersing agents on the morphology and electrical performance is studied. The ink formulations result in printed patterns with 22% of bulk copper conductivity. The optimal ink is used to print functioning near field communication antennas on polyimide film, which is found to have a high bending durability.
A New Duty Cycle Control Strategy for Power Factor Correction and FPGA Implementation (2006)

The bottleneck of digital control for power factor correction (PFC) implementations is mainly due to three aspects: high calculation requirements, high cost, and limited switching frequency compared with analog implementations. A new duty cycle control strategy for boost PFC implementations is proposed in this paper. The duty cycle is determined based on the input voltage, reference output voltage, inductor current, and reference current. The duty cycle determination algorithm includes two terms, the current term and the voltage term, which can be calculated in parallel and requires only one multiplication and three additions (subtractions) operations in digital implementation. A 400-kHz switching frequency boost PFC based on field programmable gate array implementation and its test results show that the proposed new duty cycle control strategy has great potential in the next generation of high switching frequency PFC implementations, due to its lower calculation requirement, lower cost, and better performance than the conventional PFC control methods
High-peak-power picosecond optical pulse generation from highly RF-modulated InGaAsP DH diode laser (1982)

The feasibility for generating high-peak-power ultrashort optical pulses was demonstrated from a highly RF-modulated InGaAsP DC-PBH laser diode at 1.3 μm for the first time. Measured pulse width is found to be approximately 28 ps at 7 mW averaged output power, and peak output power reached about 1.2 W at 210 MHz repetition frequency. Higher peak output and shorter optical pulses could be expected with this type of semiconductor diode laser in the near-infra-red region.
Two-photon microperimetry: sensitivity of human photoreceptors to infrared light (2019)

Microperimetry is a subjective ophthalmologic test used to assess retinal function at various specific and focal locations of the visual field. Historically, visible light has been described as ranging from 400 to 720 nm. However, we previously demonstrated that infra-red light can initiate visual transduction in rod photoreceptors by a mechanism of two-photon absorption by visual pigments. Here we introduce a newly designed and constructed two-photon microperimeter. We provide for the first time evidence of the presence of a nonlinear process occurring in the human retina based on psychophysical tests using newly developed instrumentation. Since infra-red light penetrates the aged front of the eye better than visible light, it has the potential for improved functional diagnostics in patients with age-related visual disorders.
[Nationwide surveillance of parenteral antibiotics containing meropenem activities against clinically isolated strains in 2012]. (2014)

The nationwide surveillance of antibacterial susceptibility to meropenem (MEPM) and other parenteral antibiotics against clinical isolates during 2012 in Japan was conducted. A total of 2985 strains including 955 strains of Gram-positive bacteria, 1782 strains of Gram-negative bacteria, and 248 strains of anaerobic bacteria obtained from 31 medical institutions were examined. The results were as follows; 1. MEPM was more active than the other carbapenem antibiotics tested against Gram-negative bacteria, especially against enterobacteriaceae and Haemophilus influenzae. MEPM was also active against most of the species tested in Gram-positive and anaerobic bacteria, except for multi-drug resistant strains including methicillin-resistant Staphylococcus aureus (MRSA). 2. Of all species tested, there were no species, which MIC90 of MEPM was more than 4-fold higher than those in our previous studies in 2009 or 2006. Therefore, the tendency to increase in antimicrobial resistance rates was not observed. 3. MEPM resistance against Pseudomonas aeruginosa was 17.8% (56/315 strains). Compared to our previous results, it was the lowest than that in 2006 and 2009. 4. Carbapenem-resistant Klebsiella pneumoniae, and multi-drug-resistant Acinetobacter species, which emerged in worldwide, were not observed. 5. The proportion of extended-spectrum beta-lactamase (ESBL) strains was 6.2% (59/951 strains) in enterobacteriaceae, which increased compared with that of our previous studies in 2009 or before. Whereas, the proportion of metallo-beta-lactamase strains was 1.6% (5/315 strains) in P. aeruginosa, which was stable. In conclusion, the results from this surveillance suggest that MEPM retains its potent and broad antibacterial activity and therefore is a clinically useful carbapenem for serious infections treatment at present, 17 years passed after available for commercial use in Japan.
Evaluation of 124I-NM404 as a universal agent for the detection and surveillance of intracranial malignancies. (2006)

B10 Objectives: Gliomas are uniformly lethal with average survival following diagnosis of 12 to 18 months. Biological markers coupled with techniques in molecular imaging might aid to selectively visualize intracranial gliomas. This new feasibility is important in the diagnoses, treatment, and surveillance of these lethal tumors. NM404, a novel phospholipid ether analog currently in clinical Phase 1 trials for human lung cancer, demonstrates striking tumor avidity in 32 rodent models of human cancer. The primary aim of this study was to examine the multi-modal imaging characteristics of intracranial rat gliomas by comparing 124I-NM404 with microPET and microCT against the current gold standard of gadolinium enhanced microMRI. Secondary aims are to evaluate signal to background noise in tumor versus normal brain tissue, and corroborate imaging with histology. Our goal is to determine whether NM404 might be useful in the treatment of patients with gliomas. Methods: The frontal lobes of five Fischer rats weighing between 125-150g were inoculated with 1.5x106 RG2 rat glioma cells in 5ul of methylcellulose. Seven days after inoculation, 124I-NM404 was injected intravenously (80-100μCi/0.2ml) into rats bearing tumors with maximum diameters of 7-12mm. Serial PET scans were obtained at 6, 12, 24, 48, 96 hours and at 12 days. Signal intensity was assessed by comparing the tumor-bearing side to the opposite hemisphere in the same animal. All five rats displayed signs of neurological deterioration by 12 days after inoculation. Animals were scanned using PET, MRI with gadolinium and CT and then sacrificed. Brains were harvested, digitally photographed and sent for histological analysis including microglial studies in another laboratory. Results: 124I-NM404 with PET provided a more accurate image of the tumor than MRI with gadolinium indicating the new imaging modality is better than the current gold standard. Fused CT and PET images provided an accurate three-dimensional anatomical model. NM404 uptake corresponded to tumor location by histology. Tumor signal intensity was significantly higher than background and persisted for 12 days after inoculation. Uptake of NM404 tightly correlated with tumor location as determined by histology. Interestingly, the number of viable cells within a tumor appeared to decline, indicating radiolabeled NM404 might have a therapeutic effect. Conclusion: Preliminary results indicate NM404 displays an intense avidity to gliomas. 124I-NM404 might have utility in diagnoses, treatment and surveillance of gliomas. Further studies utilizing 125I and 124I with NM404 need to be completed in order to fully characterize the imaging and therapeutic potential prior to clinical application.
A high-level synthesis methodology for low-power VLSI design (2002)

A high-level synthesis methodology for low-power design is described. With the objective of supporting the design of low-power, performance-constrained systems such as signal processing applications, the methodology enables the designer to place throughput and latency constraints on the synthesized design. A library-based design style is used, where libraries may include multiple implementations of each component type. Library components are characterized by their relative power, area, and delay performance. The methodology has been implemented in the Sierra high-level synthesis system.
Color Image Segmentation Method Based on Region Growing and Ant Colony Clustering (2009)

In this paper, a color image segmentation method is proposed based on region growing and ant colony clustering. By using the intensity similarity among pixels in the HSI color space and the edge information, seeds are first automatically selected. Then seeded region begins to grow based on color and spatial information. After that, ant colony clustering method is used to merge different regions of homogeneity. Finally good results of segmentation can be achieved. Experimental results show that this method is an effective method for image segmentation, which eliminates large quantities of cycles and calculations caused by traditional ant colony algorithm.
The natural history of epilepsy: an epidemiological view (2004)

Better information of the natural history of epilepsy has important implications for understanding the underlying neurobiology, evaluating treatment strategies, and planning healthcare resources. The traditional pessimistic view has been dispelled by results from modern community based prospective studies, showing that over 60% of newly diagnosed patients will enter remission upon treatment. Recent outcome studies suggest that medical intractability may be predicted after failure of two antiepileptic drugs. Poor prognostic factors include a high initial seizure density, symptomatic aetiology, and presence of structural cerebral abnormalities, all of which can be identified early on. Among patients who have entered remission, many will remain seizure-free after antiepileptic drug treatment is withdrawn, suggesting that the underlying seizure generating factor has remitted. Whether some of these patients have entered remission "spontaneously" is contentious because, with effective pharmacotherapy for epilepsy in use for over 100 years, the natural history of untreated epilepsy is largely unknown. Circumstantial evidence, mostly arising from resource poor countries where antiepileptic drug treatment is not readily available, indicates that spontaneous remission may occur in up to 30% of cases. Observations from these complementary sources suggest that, at the population level, prognosis of newly diagnosed epilepsy may be broadly categorised into three groups: remission without treatment, remission with treatment only, and persistent seizures despite treatment. As understanding of the prognostic factors improves, the potential of a "prognostic group specific" management approach should be explored so that effective treatments may be used in a more rational and targeted fashion.
Identifying Core Biological Processes Distinguishing Human Eye Tissues With Systems-Level Gene Expression Analyses And Weighted Correlation Networks (2017)

The human eye has several specialized tissues which direct, capture, and pre-process information to provide vision. RNA-seq gene expression analyses have been used extensively, for example, to profile specific eye tissues and in large consortium studies, like the GTEx project, to study tissue-specific gene expression patterning. However, there has not been an integrated study of multiple eye tissues expression patterning with other human body tissues. We have collated current publicly available healthy human RNA-seq datasets and a substantial subset of the GTEx project RNA-seq datasets and processed all in a consistent bioinformatic workflow. We use this fully integrated dataset to probe the relatedness and biological processes between the cornea, retina, RPE-choroid complex, and the rest of the human tissues with differential expression, clustering, and GO term enrichment tools. We also leverage our large collection of retina and RPE-choroid tissues to build the first human weighted gene correlation networks and use them to highlight known biological pathways and eye gene disease enrichment. Finally, we make these data, analyses, and visualizations available via a powerful interactive web application (http://eyeIntegration.nei.nih.gov).