gebhart/patrepeval huggingface dataset:
Abstract 1406: Downregulation of uPAR inhibits migration, invasion, proliferation, FAK/PI3K/Akt signaling, and induces senescence in papillary thyroid carcinoma cells (2011)

Abstract Papillary thyroid carcinoma (PTC) is the most common endocrine and thyroid malignancy. The urokinase plasminogen activator receptor (uPAR) plays an important role in cancer pathogenesis, including breakdown of the extracellular matrix, invasion, and metastasis. Additionally, there is increasing evidence that uPAR also promotes tumorigenesis via the modulation of multiple signaling pathways. BRAFV600E, the most common initial genetic mutation in PTC, leads to ERK1/2 hyperphosphorylation, which has been shown in numerous cancers to induce uPAR. Treatment of the BRAFV600E-positive PTC cell line, BCPAP, with the MEK/ERK inhibitor U0126 reduced uPAR RNA levels by 90%. siRNA-mediated down-regulation of uPAR in BCPAP cells resulted in drastically reduced proliferation rates and decreased clonigenic survival, as well as demonstrated senescence-associated nuclear morphology and induction of β-galactosidase activity. uPAR-knockdown BCPAP cells also displayed greatly reduced migration and invasion rates, as well as a complete loss of the cells’ plasminogen-enhanced invasiveness. Additionally, uPAR down-regulation lead to greatly decreased activity in the focal adhesion kinase (FAK)/phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway, as well as a modest reduction in ERK1/2 signaling (which remained constitutively active secondary to BRAFV600E activation), which suggests the existence of a uPAR signaling feedback loop capable of affecting the various phenotypic changes exhibited by uPAR-knockdown cells. Taken together, these data provide new evidence of a novel role for uPAR induction as a central component in PTC pathogenesis, and highlight the potential of uPAR as a therapeutic target. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1406. doi:10.1158/1538-7445.AM2011-1406
The Influence of Anxiety and Depression on Outcomes of Patients With Coronary Artery Disease (2000)

For years, patients with cardiac disease have been thought to exhibit characteristic emotional features. However, the modern understanding of the relationship between affective disorders and the heart may be traced to the mid-19th century, with the publication of Williams’ seminal text regarding “nervous and sympathetic palpitations of the heart.” 1 This was followed through the late 1800s by numerous works that described the concept of neurologically based, or “neurasthenic,” cardiac disorders. In the 20th century, large advances occurred in the area of mood-related issues that pertained to coronary artery disease (CAD) and sudden cardiac death (SCD). In his 1910 Lumleian lecture, Sir William Osler described his typical patient with angina pectoris as “a man whose engine is always set full speed ahead” and further noted his patients with cardiac disease to be “worriers.” 2 The Menningers, 3 in early psychoanalytic studies, described a characteristic tendency to suppress anger among patients with CAD, as did Helen Flanders Dunbar, 4 a pioneer of psychosomatic medicine. More recently, Stewart Wolf, in
Power Distribution of Phase-Modulated Microwave Signals in a Dispersive Fiber-Optic Link (2008)

An optical phase-modulated signal can be converted to an intensity-modulated signal in a dispersive optical fiber. Due to the intrinsic nonlinearity of optical phase modulation, higher order harmonics will be generated. In this letter, an analytical model to describe the transmission of a phase-modulated microwave signal in a dispersive radio-over-fiber (RoF) link is presented. A compact and closed-form expression of the generated harmonics at the output of the RoF link is derived. Base on the analytical model, results on the power distributions of different orders of harmonics along the RoF link as well as the upper limit of the dynamic range of the RoF system are obtained. The presented model helps simplify the design and analysis of a phase-modulation-based microwave photonic link or system.
Function-distributed mobility system for the future Internet (2010)

Recently societal requirements have become so complicated that the current Internet is facing many challenging issues to overcome. Several task forces have been working on research on the future Internet in a clean slate manner and mobility management is one of the key issues to be considered. Mobility management in the future Internet is still designed in an “all-in-one” way where all management functions are tightly kept at a single location and this results in cost inefficiency and can be an obstruction to constructing flexible systems. In this paper, we propose a function-distributed mobility management system that can enable more flexible future Internet construction. Furthermore, we show the effectiveness of our proposed system via the cost analysis with a random walk mobility model.
The Isolation of Stigmasterol and β-Sitosterol from the Common Bean, Phaseolus vulgaris (1944)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Isolation of Stigmasterol and β-Sitosterol from the Common Bean, Phaseolus vulgarisArnold C. Ott and Charles D. BallCite this: J. Am. Chem. Soc. 1944, 66, 3, 489–491Publication Date (Print):March 10, 1944Publication History Published online1 May 2002Published inissue 10 March 1944https://pubs.acs.org/doi/10.1021/ja01231a058https://doi.org/10.1021/ja01231a058research-articleACS PublicationsRequest reuse permissionsArticle Views167Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Tetracyclines inhibit Porphyromonas gingivalis‐induced alveolar bone loss in rats by a non‐antimicrobial mechanism (1994)

Tetracyclines have been widely used as adjuncts in periodontal therapy due to the antimicrobial efficacy of these drugs. Recently, their ability to inhibit host-derived matrix metalloproteinases (collagenase and gelatinase) and bone resorption in organ culture has also been invoked as a therapeutic rationale. The current study was undertaken to determine whether tetracyclines can inhibit alveolar bone loss in vivo due to a non-antimicrobial action of these drugs. Experimental periodontitis was induced by inoculating adult, male Sprague-Dawley rats with P. gingivalis (strain 381) following kanamycin/ampicillin pretreatment. Doxycycline, non-antimicrobial chemically-modified tetracycline (CMT-1) and vehicle alone were administered daily to 3 infected groups of rats (n = 6 rats per group; each group housed in a sterilized inflatable isolator) beginning 10 days after P. gingivalis inoculation. The control group (n = 6; non-infected rats) received only vehicle. After 5 weeks of daily drug administration by gastric intubation, the experiment was terminated and blood samples were taken from each animal to determine antibody levels against P. gingivalis. Plaque samples were collected from each group of animals before and after P. gingivalis inoculation and at the end of the experiment for microbiological examination. The jaws were removed from each rat, defleshed and then analyzed morphometrically and radiographically to assess bone loss. Serum antibody levels against P. gingivalis were significantly elevated in the 3 infected groups compared to the non-infected controls. This, together with the microbiologic findings, indicated that these groups of rats were infected with P. gingivalis.(ABSTRACT TRUNCATED AT 250 WORDS)
Single-strand conformation polymorphism (SSCP) analysis of the molecular pathology of hemophilia B (1993)

In the present study, we report the application of polymerase chain reaction-single-strand conformation polymorphism (PCR-SSCP) analysis to the screening of seven functionally important factor IX gene (FIX) regions (total length 2.66 kb) in 9 unrelated haemophilia B patients of Portuguese or African origin. In eight of the patients an altered migration pattern of single-stranded DNA was observed. Direct sequencing of the relevant DNA fragments unveiled the following sequence alterations: two novel mutations, namely FIXBarcelos Thr-380-Pro and FIXLousada 9bp insertion at position 31,309 or 31,318; five mutations previously reported in other ethnic groups (FIXPorto Arg-145-His, FIXLuanda Gly-207-Arg, FIXPenafiel Arg-248-Gln, FIXSesimbra Arg-333-Gln, FIXCascais Arg-333-Stop); and a normal variant, G-->T transvertion at position 6,596 in intron 2. We propose hypothetical models for the generation of the 9 bp duplication (FIXLousada). We have performed molecular modeling studies in order to predict the structure of the variant FIX molecules.
LiBH4(NaBH4)/Me3SiCl, an Unusually Strong and Versatile Reducing Agent (1989)

Amines can be obtained from amides, nitriles, and nitroalkenes, alcohols from carboxylic acids, and sulfides from sulfoxides in good yields by use of the reducing agent LiBH4/Me3SiCl. Even α-amino acids can be easily reduced to amino alcohols with retention of optical purity. Compounds 1, 3, and 5 are examples of starting materials; 2, 4, and 6 are the products obtained in yields of more than 90%.
Study of SiGe Surface Cleaning (2017)

SiGe is a promising candidate to replace Si in Fin-shaped and GAA (gate all around) FETs (field-effect transistors) due to its higher carrier mobility. However, the presence of Ge oxide in the interfacial layer (IL) between the SiGe channel and HfO2 causes an increase in interface trap density (DIT) and becomes in considerate as a defect of the device. In this study, the IL formation by a combined wet cleaning process with a subsequent annealing step is investigated by X-ray Photo-electron Spectroscopy (XPS). Finally we will present a process sequence leading up to a Ge-oxide free interlayer.
Observation and analysis of residual stress development resulting from OH impurity in optical fibers (2002)

We report experimental results on the development of residual stress due to OH impurity in optical fibers. The effect of OH impurity on residual stress is demonstrated by direct residual stress measurement. The residual stress at the outer-cladding/jacketing-tube boundary of the fiber drawn at 3.48 N was found to be -61 MPa . The residual compressive stress is attributed to the viscosity decrease induced by a significant OH impurity at the boundary, as measured by a Fourier transform infrared microscope.
A layered encryption mechanism for networked critical infrastructures (2013)

Networked critical infrastructures improve our lives, but they are attractive targets for adversaries. In such infrastructures, to secure sensitive data is vital, as the information system is a foundation of today¿s critical infrastructures, and data security is a main concern in such systems. Cryptography is an approach for data security, but this method should be altered according to various features of infrastructure networks. Since complex and distributed critical infrastructures usually spread over large geographic areas, different parts of those infrastructures have different levels of perimeter defense. Devices in weakly protected zones are more likely to be captured than those in well protected zones. If an adversary captures devices, s/he can bypass cyber security measures and obtain secret information directly. Such a threat requires a layered security mechanism that can prevent adversaries from invading the whole infrastructure network from these weak zones. In this article, we propose a layered encryption mechanism based on hash chain technology for protecting sensitive data. Besides showing the layered defense, the mechanism is also lightweight and has convenient key management. It can be used independently or as a supplement to existing security measures. We evaluate performance of the proposed mechanism over different kinds of devices.
Tutorial on Alice (2006)

Developed at Carnegie Mellon University, Alice is a programming environment where objects are manipulated in 3D worlds. Alice gives students the opportunity to learn about object-oriented programming concepts without the syntax frustrations imposed by text-based programming languages. With Alice, a programmer, in a GUI environment, selects program constructs and method invocations from lists of available choices.
Könyvismertetés: Az elárult szocializmus: a Szovjetunió összeomlásának okairól – I. rész (2019)

A Szovjetunió összeomlása nemcsak Magyarországra és közvetlen régiónkra, de az egész világra nézve súlyos következményekkel járt. Négy részben közölt minisorozatunk két amerikai szerző sikerkönyvének az epilógusa, amelyben végigtekintik és elemzik az összeomlás okairól kialakult és közkézen forgó álláspontokat.
Design Principles for Iterated Hash Functions. (2004)

This paper deals with the security of iterated hash functions against generic attacks, such as, e.g., Joux’ multicollision attacks from Crypto 04 [6]. The core idea is to increase the size of the internal state of an n-bit hash function to w&amp;gt; n bit. Variations of this core idea allow the use of a compression function with n output bits, even if the compression function itself is based on a block cipher. In a formal model, it is shown that these modifications quantifiably improve the security of iterated hash functions against generic attacks.
Synthesis of mixed polysaccharides based on cellulose (1969)

Abstract The alkaline saponification of cellulose tosylates containing the tosyloxy group at various carbon atoms of the basic unit has been studied. It has been found that this reaction leads to the formation of mixed polysaccharides containing 2.3‐ and 3.6‐anhydrorings. The monosaccharide composition of mixed polysaccharides which are anhy droderivatives of cellulose has been determined. The stereochemistry of the opening of α‐oxide rings in 2.3‐anhydroderivatives of cellulose has been considered. It is shown that the opening of 2.3‐anhydrorings by acidic and basic reagents takes place under predominant formation of basic units with altro‐configuration of the substituents on secondary carbon atoms. An investigation has been carried out with respect to the reaction of 2(3)‐O‐tosylcellulose with ammonia in methanol and DMF and with potassium acetate in phenol. It has been established that these reactions proceed through the intermediate stage of the formation of 2.3‐anhydrorings. The synthesis of mixed polysaccharides with glucose, 3‐aminoaltrose, and 2‐aminoglucose on the one hand and with altrose and glucose as basic units on the other hand is described. By the reaction of mesylcellulose with potassium acetate in phenol the synthesis of mixed polysaccharides with gluco‐ and mannopyranose units has been realized.
Corneal and retinal temperatures under various ambient conditions: a model and experimental approach. (2004)

Our simplified eye model predicts in a satisfactory way measured corneal temperatures under very different conditions. Calculations show that changing external temperatures from - 20 to + 40 degrees C affects the retinal temperature by less than 1.8 degrees C.
CLI.—The bromination of 2-nitro- and 2-acetamido-diphenyl ether (1930)

H. McCombie, W. G. Macmillan and H. A. Scarborough, J. Chem. Soc., 1930, 1202 DOI: 10.1039/JR9300001202
Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis (2022)

UK Research and Innovation (Medical Research Council) and National Institute of Health Research.
Toxicokinetic Insights are Critical to Understanding Renal Toxicity of Novel Polymyxin Analog (2015)

Renal toxicity is the major dose-limiting toxicity for polymyxin antibiotics. Previous work in our labs has suggested that DMPK parameters play a modulatory role in the renal toxicity of polymyxin analogs. The goal of this study was to characterize the toxicokinetic (TK) profile of a novel polymyxin analog (“AZ TC”) versus the standard comparator compounds, colistin and polymyxin B (PMB). AZ TC was administered to male Wistar rats for 2 or 7 days of repeat dosing, subcutaneously. TK parameters were assessed at the end of the treatment period and at 14 days and 28 days following treatment cessation. TK analysis of plasma and terminal kidney homogenate samples was conducted, with MSI-MALDI evaluation of selected kidney samples. Additionally, renal toxicity was evaluated via clinical pathology, acute kidney injury (AKI) biomarker, macroscopic and microscopic observations. TK data demonstrated preferential and continued accumulation of AZ TC in kidney over the duration of dosing. Additionally, high levels of AZ TC were detected even during the recovery phase. Based on MSI data, accumulation appeared to be preferentially in the renal cortex. In conclusion, AZ TC elimination from the kidney appears to be slower than the comparators. These TK findings correlated to the renal toxicity profile of AZ TC, which, when compared to colistin and PMB, is relatively mild, but demonstrates a sustained duration of insult, as evidenced by histopathological and AKI biomarker data.
Motor Condition Monitoring by Empirical Wavelet Transform (2018)

Bearing faults are by far the biggest single source of motor failures. Both fast Fourier (frequency based) and wavelet (time-scale based) transforms are used commonly in analyzing raw vibration or current data to detect bearing faults. A hybrid method, Empirical Wavelet Transform (EWT), is used in this study to provide better accuracy in detecting faults from bearing vibration data. In the proposed method, the raw vibration data is processed by fast Fourier transform. Then, the Fourier spectrum of the vibration signal is divided into segments adaptively with each segment containing part of the frequency band. Next, the wavelet transform is applied to all segments. Finally, inverse Fourier transform is utilized to obtain time domain signal with the frequency band of interest from EWT coefficients to detect bearing faults. The bearing fault related segments are identified by comparing rms values of healthy bearing vibration signal segments with the same segments of faulty bearing. The main advantage of the proposed method is the possibility of extracting the segments of interest from the original vibration data for determining both fault type and severity.
Effect of Electrode Microstructure on the Sensitivity and Response Time of Potentiometric NO X Sensors (2008)

Nanometric La 2 CuO 4 was synthesized with the Pechini method, co‐precipitation, and two variations of the auto‐ignition technique for fabricating NO X sensor electrodes. The auto‐ignition technique produced the most phase‐pure powder with the smallest particle size and the largest specific surface area. The sensor electrodes were subjected to various thermal treatments resulting in a variety of electrode grain sizes and distributions. The response times of the sensors were exponentially dependent on electrode grain size. Sensors with fine‐grained electrodes were able to produce a steady‐state and consistent voltage at lower temperatures; improving their response sensitivity. Sensors fabricated with powders synthesized through the auto‐ignition route responded quickly, sensitively, and reproducibility to NO.
Movement of 25-hydroxycholesterol from the plasma membrane to the rough endoplasmic reticulum in cultured hepatoma cells. (1995)

Oxysterols serve as both substrates and signal molecules in the cholesterol-utilizing pathways of mammalian cells. Their distribution and movement within these cells, however, have not been well characterized; therefore we have undertaken such an analysis. Radiolabeled cholesterol and 25-hydroxycholesterol were pulsed into the cell surface membranes of rat hepatoma cells and their esterification was determined. The esterification of both probes was stimulated by feeding cells lipoproteins, even though lipoprotein cholesterol might be viewed as a competitor. Unlabeled 25-hydroxycholesterol, another potential competitor, also stimulated the esterification of the cell-surface probes. Esterification of both sterols was inhibited by a variety of amphiphilic agents. This inhibition was reversed by unlabeled 25-hydroxycholesterol. In cells incubated at 15 degrees C the fractional rate of esterification of the oxysterol was more than 100 times greater than that of cholesterol. Furthermore, the time course of esterification of plasma membrane cholesterol but not that of 25-hydroxycholesterol, was lagged. In contrast, the rate of esterification of the two probes was similar in broken cells supplied with saturating cholesterol. Finally, the transfer of 25-hydroxycholesterol from red blood cells to plasma lipoproteins was approximately 2000-fold faster than that of cholesterol. We conclude that 25-hydroxycholesterol and cholesterol are moved between the plasma membrane and endoplasmic reticulum by a common transport mechanism but that the oxysterol enters this pathway much more rapidly, possibly through a passive transfer step akin to its unmediated transfer from red cells to plasma.
Prevalence and risk factors for udder cleft dermatitis in dairy cattle (2013)

Udder cleft dermatitis (UCD) is a skin lesion in dairy cattle mostly located at the anterior junction between the udder and the abdominal wall or between the front quarters. Relatively little is known about causative factors for UCD, and few studies have investigated prevalence and risk factors of UCD. Therefore, the aim of this study was to investigate the prevalence of UCD in a random sample of dairy herds with freestalls and milking parlors in a county of Sweden. Thirty dairy herds participated in the study. Each herd was visited once at milking, when every third cow was investigated for presence of UCD. Associations between UCD and milk production, breed, parity, days in milk, claw health, and udder health on the herd and cow levels were also investigated. In addition, a case-control study was performed in 6 herds with a high prevalence of UCD to investigate associations between udder conformation or mange and UCD. Udder cleft dermatitis was found in 18.4% of the 1,084 cows included in the study. The within-herd cow prevalence varied between zero and 39%, with an average of 18.5%. Risk factors for UCD at the herd level were a high proportion of Swedish Red cows and a high production level. At the cow level, breed, parity, and production level were identified as risk factors. The highest risk of having UCD was found in high-producing Swedish Red cows that had calved at least 3 times. Veterinary-treated clinical mastitis was associated with UCD, but cow composite somatic cell count was not. A strong anterior udder attachment was a protective factor, but signs of mange had no association with UCD. The primary cause of UCD is still unclear, and more research is needed to identify the best ways to prevent the development of this animal welfare problem.