gebhart/patrepeval huggingface dataset:
Mesenteric Castleman's Disease (2005)

We report here a rare case of mesenteric Castleman's disease presenting as a mesenteric mass. A 13-year-old female child was admitted to our hospital complaining of intermittent vague abdominal pain. She had hypochromic anemia, thrombocytosis and an elevated erythrocyte sedimentation rate (ESR). Ultrasonography and computed tomography indicated an intra- abdominal mass might represent a lymphoma or gastrointestinal stromal tumor or leiomyoma, but the definitive preoperative diagnosis couldn't be confirmed. The surgical resection of the mass revealed the mesenteric hyaline vascular-type Castleman's disease.
ChemInform Abstract: Synthesis of Pyridazine‐Based Scaffolds as α‐Helix Mimetics. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
EFFECTS OF TWO SUBSTITUTED BENZAMIDES, TIAPRIDE AND SULTOPRIDE, ON GONADOTROPHINS AND PROLACTIN (1978)

ABSTRACT The acute effects in the human of tiapride and sultopride, two new substituted benzamides related to sulpiride, were studied with respect to gonadotrophins (LH and FSH) and prolactin (PRL) secretion. Two different groups of 3 normal men and 3 normally cycling women received im injections of either 100 mg sultopride or 200 mg tiapride. Five min after the injection of either psychotropic drug, the serum PRL concentration increased significantly ( P &lt; 0.001 by variance analysis) and reached maximal values by 30 min and remained elevated for at least 6 h; women tended to release more prolactin than men. Although tiapride (500 n m ) had no direct effect on the in vitro synthesis or secretion of prolactin, the drug blocked the inhibitory action of dopamine (500 n m ) on the secretion of prolactin. Rats bearing a transplantable prolactin-secreting pituitary tumour MtTW15 have extremely high serum prolactin and through an autofeed mechanism the host's pituitary gland is suppressed. The in vitro synthesis and secretion of prolactin by these rats' pituitary gland is decreased. The in vivo administration of tiapride to these tumour-bearing rats restored the in vitro secretion of prolactin to control values. The in vitro data support the concept that tiapride increases prolactin secretion directly at the pituitary level by blocking the inhibitory activity of dopamine; an additional effect at a higher level can not, however, be ruled out. In vivo in the human, no significant modification of LH and FSH occurred after either drug, suggesting that the menstrual cycle disturbances observed during chronic treatment with tiapride might be related to hyperprolactinaemia or be the result of a mechanism similar to that inducing hyperprolactinaemia.
An Experimental and Numerical Investigation of Cardiac Tissue-Patch Interrelation (2023)

Tissue engineered cardiac patches have great potential as a regenerative therapy for myocardial infarction. Yet, the mutual interaction of cardiac patches with healthy tissue has not been completely understood. Here, we investigated the impact of acellular and cellular patches on a beating two-dimensional (2D) cardiac cell layer, and the effect of the beating of this layer on the cells encapsulated in the patch. We cultured human-induced pluripotent stem cell-derived cardiomyocytes (iCMs) on a coverslip and placed gelatin methacryloyl hydrogel alone or with encapsulated iCMs to create acellular and cellular patches, respectively. When the acellular patch was placed on the cardiac cell layer, the beating characteristics and Ca+2 handling properties reduced, whereas placing the cellular patch restored these characteristics. To better understand the effects of the cyclic contraction and relaxation induced by the beating cardiac cell layer on the patch placed on top of it, a simulation model was developed, and the calculated strain values were in agreement with the values measured experimentally. Moreover, this dynamic culture induced by the beating 2D iCM layer on the iCMs encapsulated in the cellular patch improved their beating velocity and frequency. Additionally, the encapsulated iCMs were observed to be coupled with the underlying beating 2D iCM layer. Overall, this study provides a detailed investigation on the mutual relationship of acellular/cellular patches with the beating 2D iCM layer, understanding of which would be valuable for developing more advanced cardiac patches.
EU-US standards harmonization task group report : testing for ITS communications. (2012)

Harmonization Task Groups 1 and 3 (HTG1 and 3) were established by the EU-US International Standards Harmonization Working Group to attempt to harmonize standards (including ISO, CEN, ETSI, IEEE) on security (HTG1) and communications protocols (HTG3) to promote cooperative ITS interoperability.\n
Preparation and characterization of imidazole–metal complexes and evaluation of cured epoxy networks (1994)

A series of copper complexes of epoxy-imidazole adducts have been prepared and characterized by 1H nuclear magnetic resonance (NMR) spectroscopy. Differential scanning calorimetry (DSC) was employed to investigate the thermal behaviour of the curing agents and to investigate the medium-term storage stability of a one-pot composition of a commercial epoxy resin when mixed with the complexes. The cure onset temperatures of the mixtures containing copper complexes are ca. 20–50 °C higher than those of the parent epoxy-imidazole adducts and the decrease of cure onset temperatures in the early stages of storage (up to 100 h) is less. The latent nature and improved storage stability of mixtures containing the copper complex were clearly demonstrated and confirmed by the viscosity behaviour of the catalysed mixtures of the commercial epoxy resins MY720 and MY750. 1H NMR and electron paramagnetic resonance (EPR) spectroscopy were employed to monitor the thermal decomposition of the copper(II) complexes, which were found to decompose at 120–130 °C and exist in equilibrium. Glass fibre-reinforced composite samples were prepared using a commercial epoxy resin cured with the complexes and their physico-mechanical properties were evaluated.
Titelbild: Umkodierung des genetischen Codes mit Selenocystein (Angew. Chem. 1/2014) (2013)

Das nach Selene, der Mondgöttin benannte Selenocystein (Sec) zeichnet sich durch eine einzigartige Katalysekraft und die Insertion in Proteine durch die Umkodierung spezifischer UGA-Stopcodons zu Sec aus. In der Zuschrift auf S. 325 ff. beschreiben D. Söll, P. O'Donoghue et al. die Entwicklung einer Sec-Insertions-Maschinerie, um fast alle 64 Codons umzukodieren. Dabei ist die ringförmige decamere Selenocystein-Synthase SeIA für die Bereitstellung von tRNA-gebundenem Sec als zentralem Baustein für die Selenoproteintranslation essenziell.
Effects of dapagliflozin and n-3 carboxylic acids on non-alcoholic fatty liver disease in people with type 2 diabetes: a double-blind randomised placebo-controlled study (2018)

ClinicalTrials.gov NCT02279407 FUNDING: The study was funded by AstraZeneca.
Solid-State 31P NMR Chemical Shielding Tensors in Phosphonates and Bisphosphonates:  A Quantum Chemical Investigation (2004)

We report the results of a quantum chemical investigation of the 31P nuclear magnetic resonance (NMR) isotropic chemical shieldings (σiso) and the 31P NMR chemical shielding tensor principal values (σii, i = 1−3) in a series of eight different phosphonates, including the bisphosphonates pamidronate and risedronate currently in use in bone resorption therapy. We used primarily Hartree−Fock methods with a 6-311++G(2d,2p) basis set and the CSGT (continuous set of gauge transformations) formalism to predict the experimental observables, using various approaches to incorporating intermolecular, crystal lattice effects. Good predictions of the 31P NMR isotropic chemical shielding, shielding tensor principal values, and tensor orientations were obtained, with R2 = 0.95 and ∼7% root-mean-square error from experiment. In the zwitterionic aminophosphonates, electrostatic (lattice) interactions were found to be strong but could be well accounted for by incorporating charge lattice effects into the calculations. The ability to now predict both isotropic and anisotropic shielding (shift) tensors in phosphonates and bisphosphonates should open the way to the determination of their protonation states when bound to proteins, information which is not accessible from crystallographic studies.
Near-Infrared Raman Spectra of Azo Dye Produced by a Nitrogen-Dioxide-Gas-Selective Coloration Reaction in a Porous Glass Chip (2001)

We directly observed azo dye in a porous glass chip by near-infrared (NIR) Raman spectroscopy. We produced the dye by a modified Saltzman reaction by using sulfanilamide (SFA) and N, N-dimethyl-1-naphthylamine (DMNA) as reagents and used it for the selective sensing of atmospheric nitrogen dioxide gas (NO 2 ). The use of NIR laser excitation is particularly advantageous for the direct measurement of azo dye because it avoids the problem of interference from fluorescence. We obtained the 1597 cm −1 band assigned to the phenyl group stretching mode and the 1415 cm −1 band assigned to the azo group stretching mode. The Raman intensity and visible absorption intensity of the peaks of the azo dye in a porous glass chip increased as we increased the exposure time to NO 2 . This allowed us to monitor the NO 2 -sensing reaction in a porous glass chip using NIR Raman spectroscopy. Furthermore, we determined the depth profiles of the azo dye concentration in the porous glass chip by confocal NIR Raman spectroscopy and found that they were different in the early and later NO 2 -exposure stages. This result indicates that the consumption of the NO 2 -sensing reagents that accompany azo dye production occurs preferentially at the surface to the deeper regions of the porous glass chip.
Measurement equivalence of the English, Chinese and Malay versions of the World Health Organization quality of life (WHOQOL-BREF) questionnaires (2019)

The English, Chinese and Malay language versions of the WHOQOL-BREF questionnaire may be considered equivalent, with evidence being more robust for some domains than the others. Given the large number of people who speak/ read Chinese and Malay, this study has widespread relevance.
Podium Presentation Title: Bankart Repair With Remplissage vs. Latarjet for Anterior Shoulder Instability (2023)

remplissage.Conclusion: Open Bankart and arthroscopic Bankart with remplissage have similar failure rates for the treatment of anterior instability with subcritical GBL at index instability surgery or in the revision setting.
On and Off Site Sediment Control Using Silt Fence (2004)

Greater public awareness and the enactment of increasingly stringent regulations have made reliable and cost-effective erosion control methods or best management practices (BMPs), particularly on construction sites, a national priority. At present, silt fence is the most widely used BMP, but unfortunately, the instances of failure are widespread. We believe that with proper assessment, following recommended installation methods, and conducting routine maintenance, better erosion control can be achieved with current silt fence technology. The current phase of our research is to investigate the current technology and develop design tools to assist users to get better results through avoiding structural failures and also provide a means of assessing performance in terms of trapping efficiency or effluent concentration. The next phase of our research will be to develop and evaluate several structural, material, and chemical enhancements to the current technology. This paper describes the progress made to date in investigation of current technology and development and application of the design tool.
Measurements and Evaluations of Neutron Dose and Spectra at the Reactor Top of the Liquid-Metal Fast Breeder Type Reactor, JOYO (1987)

To investigate the neutron dose and spectra around a fast reactor from the point of view of radiation protection and shielding, neutron measurements were conducted at the reactor top of JOYO, a Japanese experimental fast reactor, and an analysis by a transport calculation was performed. The measurements were carried out under a Mark II irradiation core with and without the reactor top concrete pit cover at 98- and 48-MW(thermal) power levels, respectively. The measurements were performed at several points in and around the reactor top pit room. Neutron detectors with well-examined response functions were employed for this study–the rem (sievert) counter as a neutron dosimeter and the multimoderator neutron detector as a neutron spectrometer. The measured neutron doses distributed from 0.4 to 100 mrem/h·[100 MW(thermal)]−1 {4 to 1000 μSv/h· [100 MW(thermal)]−1} and the measured neutron spectra showed an ∼1/E type energy distribution. The rapid spatial change of the neutron spectrum could not be observed near the reactor top. The neutron flux distributions around the reactor were calculated and compared with the measured results. The two-dimensional transport code DOT 3.5 was employed for the calculation, and the neutron group constants were prepared by using JENDL-2 cross-section libraries. The values of measurements and calculations were in relatively good agreement within a factor of 3 to 5 in spite of the 12-decade decrease in neutron flux from the reactor core center. It is shown that the effect of stored fuels in invessel storage racks has greatly affected the neutron dose rate at the reactor top. The modeling for shielding calculations of the iron rotating plug structures is discussed.
Large scale integration of wind energy in Colombia: Electrical analysis-part II (2012)

This work constitutes the second part of a study that aims to analyze the technical and economic implications of the penetration of wind power in the Colombian Interconnected System (SIN). In the previous part of the work, steady state studies were carried out (loading at transmission corridors, short circuit and the most important contingencies were applied). A summary with the main problems encountered and their respective solutions were proposed. In this second part, the same group of wind farms and time horizon were employed, while dynamic models were fit to ensure the proper operation of controls against the contingences. Using the software DigSilent™, studies of stability (with and without controls), power quality (flicker analysis), and voltage ride through capability (VRT) were addressed. Finally, technical recommendations and further work are presented.
Selective turn-on fluorescent probes for imaging hydrogen sulfide in living cells (2012)

Hydrogen sulfide (H(2)S) is an important biological messenger but few biologically-compatible methods are available for its detection. Here we report two bright fluorescent probes that are selective for H(2)S over cysteine, glutathione and other reactive sulfur, nitrogen, and oxygen species. Both probes are demonstrated to detect H(2)S in live cells.
Electro-thermal Simulations of Nanoscale Transistors with Optical and Acoustic Phonon Heat Conduction (2005)

In order to take into account the nanoscale heat generation and phonon heat conduction, the optical and acoustic phonon temperature system for TCAD simulation is developed and self-consistently coupled with the hydrodynamic transport model. This electrothermal model is validated through the simulations of a thin-body SOI NMOSFET.
Characterization of Selectively Deposited Cobalt Capping Layers: Selectivity and Electromigration Resistance (2010)

Co films were selectively deposited as Cu capping layers by chemical-vapor-deposition technique. X-ray fluorescence spectroscopy determined the Co deposition selectivity as a function of the deposition temperature and substrate materials. The Co/Cu interfacial property was characterized and revealed no detectable oxygen at the interface. The selectivity of the Co deposition process and the property of the resulted Co/Cu interface were further confirmed with time-dependent-dielectric-breakdown and electromigration tests.
Expression of the human microRNA miR 29a in an Indian cohort of HIV patients (2014)

Background The events during host virus interaction pave the way to differential outcomes in HIV-1 disease progression rates. We have earlier shown that HIV-1Nef gene harbors target sites for the human microRNA, miRNA 29a/b. Over expression of miR 29a/b could reduce virus levels by targeting the Nef gene. We hypothesized that differential expression of the microRNA maybe a protective factor in AIDS progression.
Feasibility of Single-Agent Localization from Sequential Measurements (2018)

Localization from a sequence of measurements is feasible when the localization error does not increase over time. Under the widely adopted Bayesian filtering perspective, the computation of this bound and the proof of its underlying results become intricate. This paper characterizes the necessary conditions for feasible localization of a single agent. In particular, we find closed- form expressions for the necessary conditions that the position or distance measurements must satisfy in localization systems to guarantee that the error bound does not increase over time. We corroborate the obtained expressions with numerical results revealing the usefulness of the conducted research in a case study of wireless localization.
Energy Consumption Measurement Technique for Automatic Instruction Set Characterization of Embedded Processors (2007)

The steadily increasing performance of mobile devices implies also a rise in power consumption. To counteract this trend it is mandatory to accomplish software power optimizations based on accurate power consumption models characterized for the processor. This paper presents an environment for automated instruction set characterization based on physical power measurements. For an accurate current measurement a high performance sampling technique has been established, which can be either clock or energy driven. The performance of those techniques is analyzed and the advantages over the conventional solution of a series resistor are discussed.
Loss of G 1 /S Checkpoint in Human Immunodeficiency Virus Type 1-Infected Cells Is Associated with a Lack of Cyclin-Dependent Kinase Inhibitor p21/Waf1 (2000)

Productive high-titer infection by human immunodeficiency virus type 1 (HIV-1) requires the activation of target cells. Infection of quiescent peripheral CD4 lymphocytes by HIV-1 results in incomplete, labile reverse transcripts and lack of viral progeny formation. An interplay between Tat and p53 has previously been reported, where Tat inhibited the transcription of the p53 gene, which may aid in the development of AIDS-related malignancies, and p53 expression inhibited HIV-1 long terminal repeat transcription. Here, by using a well-defined and -characterized stress signal, gamma irradiation, we find that upon gamma irradiation, HIV-1-infected cells lose their G(1)/S checkpoints, enter the S phase inappropriately, and eventually apoptose. The loss of the G(1)/S checkpoint is associated with a loss of p21/Waf1 protein and increased activity of a major G(1)/S kinase, namely, cyclin E/cdk2. The p21/Waf1 protein, a known cyclin-dependent kinase inhibitor, interacts with the cdk2/cyclin E complex and inhibits progression of cells into S phase. We find that loss of the G(1)/S checkpoint in HIV-1-infected cells may in part be due to Tat's ability to bind p53 (a known activator of the p21/Waf1 promoter) and sequester its transactivation activity, as seen in both in vivo and in vitro transcription assays. The loss of p21/Waf1 in HIV-1-infected cells was specific to p21/Waf1 and did not occur with other KIP family members, such as p27 (KIP1) and p57 (KIP2). Finally, the advantage of a loss of the G(1)/S checkpoint for HIV-1 per se may be that it pushes the host cell into the S phase, which may then allow subsequent virus-associated processes, such as RNA splicing, transport, translation, and packaging of virion-specific genes, to occur.
Three-Phase Interleaved LLC Asymmetric Resonant Converter With Capacitive Current Balancing and Reduced Switch Voltage Stress (2019)

Interleaved converters are a typical solution to enhance a current capacity and to reduce current ripples of an input or output port. Conventional interleaved LLC resonant converters need additional switches and passive components with a feedback control loop for active current balancing, increasing the circuit complexity and cost. This paper proposes a novel three-phase interleaved LLC resonant converter with an automatic capacitive current balancing capability. Two flying capacitors are added to a conventional interleaved LLC resonant converter in order to realize not only the automatic capacitive current balancing but also the reduced switch voltage stresses and asymmetric resonant operations that contribute to reducing rms currents as well as copper losses of transformers. The detailed operation analysis, including the capacitive current balancing mechanism and gain characteristics derivation, are performed. The experimental verification using a 1-kW prototype demonstrated that the automatic capacitive current balancing could be achieved despite the significant mismatch in transformers' parameters.
A six-month study of two self-applied tooth whitening products containing carbamide peroxide. (2005)

Bleaching offers a non-interventive way of improving the appearance of sound, yet discolored anterior teeth. Until recently, the whitening agent was applied using a tray, but now other methods of delivering whitening agents, such as those using brush applicators, are available. This study investigated the tooth whitening efficacy of two novel, self-applied tooth whitening systems containing either 18% (Group 1) or 16.4% (Group 2) carbamide peroxide. Ninety-five subjects, ranging in age from 18 to 70 with anterior teeth A3 or darker, were recruited and randomly allocated to a group. The subjects were instructed to apply the formulation to all maxillary anterior teeth after brushing in the morning and evening. At baseline, two weeks and six months the upper six anterior teeth of the subjects were measured using the Vita shade guide tab system. In addition, the gingival health of the labial surfaces of the upper six anterior teeth was assessed using the Loee and Silness Gingival index (Loee & Silness, 1963) at baseline and at two weeks. The mean (SD) reduction in shade guide scores was 4.1 (2.4) shade guide tabs for subjects in Group 1, compared to 3.7 (2.6) shades for those in Group 2. This difference was not statistically significant (p=0.5). During the course of study, the gingivitis scores reduced from a mean (SD) of 0.91 (0.62) at baseline to 0.44 (0.55) at final examination (48% reduction). At the six-month recall, the mean (SD) reduction in shade guide scores was 2.3 (2.7) shade guide tabs for subjects in Group 1, compared to 2.5 (2.5) shades for those in Group 2. The different concentrations tested were found to be equally effective in improving the whiteness of upper anterior teeth by approximately four shades over a two-week period and the majority of the whitening benefit (c.60%) was sustained at six-month recall.