gebhart/patrepeval huggingface dataset:
The Power and Prospects of Fluorescence Microscopies and Spectroscopies (2003)

Recent years have witnessed a renaissance of fluorescence microscopy techniques and applications, from live-animal multiphoton confocal microscopy to single-molecule fluorescence spectroscopy and imaging in living cells. These achievements have been made possible not so much because of improvements in microscope design, but rather because of development of new detectors, accessible continuous wave and pulsed laser sources, sophisticated multiparameter analysis on one hand, and the development of new probes and labeling chemistries on the other. This review tracks the lineage of ideas and the evolution of thinking that have led to the actual developments, and presents a comprehensive overview of the field, with emphasis put on our laboratory's interest in single-molecule microscopy and spectroscopy.
Effects of Pressure and Temperature on Gas Diffusion and Flow for Primary and Enhanced Coalbed Methane Recovery (2014)

Due to the rapid increase of coalbed methane (CBM) exploration and development activities in China, gas adsorption and flow behavior for Chinese coals are of great interest for the industry and research community. How pressure and temperature affect the gas adsorption and flow on different rank coals are not only important for CBM recovery but also important for CO 2 or N 2 enhanced CBM recovery, since gases are often injected at a temperature different to the reservoir temperature. In this work, gas adsorption and permeability of three different rank Chinese coals are measured using CH 4 , N 2 and CO 2 at three temperatures, 20°C, 35°C and 50°C. Gas diffusivity and permeability with respect to gas species, pore pressure, effective stress and temperature are studied. The three coals are SQB-1 from Southern Qinshui Basin, JB-1 from Junggar Basin and OB-1 from Ordos Basin. Gas adsorption results show that both pressure and temperature have significant impact on adsorption behavior for SQB-1 and JB-1 using CH 4 . For higher rank coal SQB-1, adsorption isotherm tends to reach adsorption capacity quicker with respect to pressure. However, the maximum adsorption capacity is higher for the lower rank coal JB-1. Moreover, temperature has a stronger effect on reducing adsorption capacity for lower rank coal. Gas diffusivity results for OB-1 and JB-1 show that CO 2 diffusivity is generally higher than that of CH 4 and then N 2 . This could be related with their different kinetic diameters and their interaction with the coal. Both pressure and temperature have impact on gas diffusivity. In general, gas diffusivities increase with pressure and temperature. Permeability results show that it varies greatly with respect to coal rank with highest rank coal having the lowest permeability. Permeability is also strongly sensitive to effective stress and pore pressure. Temperature has a noticeable impact on permeability change. Permeability changes differently with temperature increase for the different rank coal samples studied. This may be attributed to the combined effect of coal strain change due to gas adsorption and thermal expansion. These results have significant implications for the design of enhanced CBM recovery and CO 2 storage for different rank coals as injecting gas at different temperature and pressure would affect the CO 2 injectivity and the CBM production rate.
The Cram&#x00E9;r-Rao bound for estimation-after-selection (2014)

In many practical parameter estimation problems, a model selection is made prior to estimation. In this paper, we consider the problem of estimating an unknown parameter of a selected population, where the population is chosen from a population set by using a predetermined selection rule. Since the selection step may have an important impact on subsequent estimation, ignoring it could lead to biased-estimation and an invalid Cramér-Rao bound (CRB). In this work, the mean-square-selected-error (MSSE) criterion is used as a performance measure. The concept of Ψ-unbiasedness is introduced for a given selection rule, Ψ, by using the Lehmann-unbiasedness definition. We derive a non-Bayesian Cramér-Rao-type bound on the MSSE of any Ψ-unbiased estimator. The proposed Ψ-CRB is a function of the conditional Fisher information and is a valid bound on the MSSE. Finally, we examine the Ψ-CRB for different selection rules for mean estimation in a linear Gaussian model.
Pictures open unexpected horizons in Nepal. (1986)

Picture literacy constitutes one of the main accomplishments of Nepal's nonformal education program. Although program participants had little difficulty initially in identifying pictured objects, they were unable to understand the meaning or intended message of an illustration. In classroom discussions, participants were asked to analyze pictures, relate them to their own experiences, and read more meaning into illustrations. As the literacy curriculum was developed and tested, it became clear that the use of pictures greatly increased the number of meaningful ideas that could be communicated in the lessons. Comics were especially valuable in introducing social issues in a dramatic, exciting way that could not be achieved through stories with a limited vocabulary. While the written story must be coherent, the comic can be fragmentary and more ground can be covered. The pictures make the page less formidable and reinforce the written word. Once pictures and comics had been introduced into the literacy curriculum, experimentation with other uses was possible. For example, participants role-played the comics and created their own stories around discussion pictures. All these activities proved to be educationally sound and appropriate to the cultural setting.
Polymer-Based Transmission Path for Communication and Sensing Applications (2018)

Optical transmission paths consisting of waveguides, light sources, and detectors form basic components in a large variety of applications ranging from photonic sensors to short distance communication. We demonstrate the design and fabrication of a polymer transmission path, which incorporates standard semiconductor light sources. In this paper, we especially focus on low-cost fabrication of such systems including easy-to-fabricate and optically efficient coupling structures. Our concept relies on self-written waveguide interconnects, which can be created without complex equipment and compensates for misalignment of the components to be connected automatically. Out-coupling toward a photodiode is achieved using a grating coupler. In addition, we present optical characterization results of the components regarding losses and demonstrate signal propagation.
Temperature effect on pull-off force for gold cantilevers array (2019)

This paper focuses on revealing the length influence of a group of gold cantilevers on the mechanical behaviour (i.e. bending stiffness, Young modulus, pull-off force) on the one hand and on the investigation of the temperature influence on the pull-off force of thermally actuated microcantilevers, on the other hand. The length was ranged between 200 μm and 350 μm while the temperature was ranged between 20 °C to 100 °C. The tests were performed using an atomic force microscope. The results obtained in the study are important to enhance the design of MEMS devices and to increase their reliability and their lifetime.
An unsupervised learning approach to assembly validation (2013)

The dramatic decrease in sequencing cost has led to an unprecedented number of new projects. Because finishing a genome often involves painstaking work, most sequencing efforts are satisfied by an initial draft assembly. Reliable analysis of synteny, gene expansion, and structural variation, however, is contingent upon the available draft being an accurate representation of the genome. If the genome has not been thoroughly vetted, this trust may be misplaced and misassemblies can undermine any conclusions drawn about the structure and content of a genome. Here, we developed and tested the use of unsupervised learning algorithms to uncover outliers that point to improperly assembled segments. We first modified the existing amosvalidate software to extract detailed assembly features from the raw assembly file. We then used this information to construct feature vectors for each section of the assembly, and clustered these using various unsupervised learning techniques. Our results show that misassembled regions clearly differentiate themselves from correctly assembled regions, particularly in certain dimensions such as read coverage and SNP placement.
Can Multiple Lifestyle Behaviours Be Improved in People with Familial Hypercholesterolemia? Results of a Parallel Randomised Controlled Trial (2012)

Dutch Trial Register NTR1899.
Effects of the 2020 health crisis on acute alcohol intoxication: A nationwide retrospective observational study (2021)

The decrease in the number of hospitalizations for AAI in 2020 could be explained by several factors: fewer available hospital beds due to COVID-19, individuals with AAI delaying or avoiding medical care due to COVID-19 fears, and decreases driven by younger age groups returning to live with parents and socializing less. While alcohol consumption patterns have changed with the implementation of social distancing measures and lockdowns, the increase in mortality and the share of hospitalizations with complications suggest that these measures had an impact on event severity in a context of strained access to healthcare.
Halophilic adaptation of protein–DNA interactions (2003)

Pyrococcus woesei ( Pw ) is an archaeal organism adapted to living in conditions of elevated salt and temperature. Thermodynamic data reveal that the interaction between the TATA-box-binding protein (TBP) from this organism and DNA has an entirely different character to the same interaction in mesophilic counterparts. In the case of the Pw TBP, the affinity of its interaction with DNA increases with increasing salt concentration. The opposite effect is observed in all known mesophilic protein-DNA interactions. The halophilic behaviour can be attributed to sequestration of cations into the protein-DNA complex. By mutating residues in the Pw TBP DNA-binding site, potential sites of cation interaction can be removed. These mutations have a significant effect on the binding characteristics, and the halophilic nature of the Pw TBP-DNA interaction can be reversed, and made to resemble that of a mesophile, in just three mutations. The genes of functionally homologous proteins in organisms existing in different environments show that adaptation is most often accompanied by mutation of an existing protein. However, the importance of any individual residue to a phenotypic characteristic is usually difficult to assess amongst the multitude of changes that occur over evolutionary time. Since the halophilic nature of this protein can be attributed to only three mutations, this reveals that the important phenotype of halophilicity could be rapidly acquired in evolutionary time.
Industrial implementation of a back-to-back intertie using two standard drives-a retrofit solution to obtain a clean utility interface (2002)

Tighter power quality regulations stipulate improvement in utility interface of the existing and new industrial drives employed in a typical process plant. A generic variable speed drive draws power from the utility through a passive rectifier which is the primary source of harmonics that pollute the utility. Several topologies for passive and active filters have been studied extensively to mitigate these harmonics in the past few years. However, the filtering approach needs extensive system studies and is not a commercially viable option in the present day market. As an alternative, industrial drives with active rectifiers are also gaining popularity as a drive with harmonic-free utility interface. In addition to supporting the development cost of an entirely new product (which reflects in the higher premium for the end-customer), this active rectifier approach poses significant shortcomings in solving the problems of the drives that are already commissioned and are currently in use today. This paper presents a systematic methodology to couple two standard industrial drives which can be bought off the shelf to form a back-to-back intertie. The inverter side of this intertie drives the motor while the rectifier side ensures a harmonic-free interface with the utility. This arrangement can be used either as a retrofit solution for the pre-existing industrial drive at the cost of just one new standard drive, or it can be installed as a completely new system. This solution does not require any system studies for reliable operation and can be tacked on with least disturbance to the existing drive set-up. The proposed scheme is verified through extensive system simulations and experimental testing of a prototype in the laboratory.
Two-month stop in mammographic screening significantly impacts on breast cancer stage at diagnosis and upfront treatment in the COVID era (2021)

Our data showed an increase in node-positive and stage III BC after a 2-month stop in BC screening. These findings support recommendations for a quick restoration of BC screening at full capacity, with adequate prioritization strategies to mitigate harm and meet infection prevention requirements.
Domain reversal in single crystal strontium barium niobate (Sr0.61Ba0.39Nb2O6) (2004)

The first systematic domain reversal for crystal strontium barium niobate (Sr0.61Ba0.39Nb2O6, SBN:61), such as coercive fields, polarization, wall mobilities are reported. Its 4-fold rotational symmetry of the domain shape is reported for the first time.
Ship Propulsion AC/DC Conversion System Modeling and Design (2006)

This paper presents the detailed physics-based model and design of a high voltage high power AC/DC power conversion system comprising a 3 to 12 phase transformer and a 24 pulse thyristor controlled rectifier. System level modeling is critical during the multi-year design of the 30-50 MW system. The goal of the modeling effort is to avoid re-designing the system which is expensive to prototype due to the large power level. The paper presents two important performance features of the model. The conducted emissions are simulated for the AC/DC system and compared to the MIL-STD-461E and MIL-STD-1399 limits to help choose filter components. Control of the DC bus voltage is also simulated to predict the step response of the system and ensure the performance requirements can be satisfied when the proof of concept occurs
Implementing asynchronous circuits using a conventional EDA tool-flow (2002)

This paper presents an approach by which asynchronous circuits can be realised with a conventional EDA tool flow and conventional standard cell libraries. Based on a gate-level asynchronous circuit implementation technique, direct-mapping, and by identifying the delay constraints and exploiting certain EDA tool features, this paper demonstrates that a conventional EDA tool flow can be used to describe, place, route and timing-verify asynchronous circuits.
Boolean matching of sequential elements (1994)

Article Free Access Share on Boolean matching of sequential elements Authors: Shankar Krishnamoorthy Synopsys Inc., 700C, E.Middlefield Rd., Mountain View, CA Synopsys Inc., 700C, E.Middlefield Rd., Mountain View, CAView Profile , Frederic Mailhot Synopsys Inc., 700C, E.Middlefield Rd., Mountain View, CA Synopsys Inc., 700C, E.Middlefield Rd., Mountain View, CAView Profile Authors Info & Claims DAC '94: Proceedings of the 31st annual Design Automation ConferenceJune 1994 Pages 691–697https://doi.org/10.1145/196244.196617Published:06 June 1994Publication History 2citation241DownloadsMetricsTotal Citations2Total Downloads241Last 12 Months36Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Evaluation of Nanocrystalline Coatings for Coal-Fired Ultra-Supercritical Boiler Tubes (2009)

Cyclic oxidation behavior and microstructural degradation of nanocrystalline Ni-20Cr-xAl (where x = 4, 7, and 10 wt.%) coatings have been investigated. The coatings were deposited on Haynes 230 samples using a magnetron sputtering technique. Cyclic oxidation tests were conducted on the coated and uncoated samples at peak temperatures of 750°C and 1010°C for up to 2070 thermal cycles between the peak and room temperatures. The results showed that a dense Al2O3 scale was formed on the external surface of all coatings after exposure at both temperatures. All three coatings showed no evidence of internal oxidation after exposure at 750°C. Among the three coatings, the coating containing 4 wt.% Al only showed evidence of internal oxidation along the columnar grain boundaries after exposure at 1010°C. The Al2O3 scale exhibited good spallation resistance during cyclic oxidation tests at both temperatures. As the Al content in the coating increased from 4 to 7 or 10 wt.%, thermal exposure led to precipitation of coarse Al-rich particles at the coating/substrate interface. In addition, thermal exposure at both temperatures led to rapid depletion of Al in the coating and grain coarsening of the coatings. The improvement in oxide scale spallation resistance and accelerated depletion of aluminum are attributed to the ultrafine grain structure of the coating and oxide scale.
Simplified rear-side patterning for silicon heterojunction IBC solar cells: development of the in situ “nano-envelope” dry clean (2018)

The heterojunction interdigitated back-contact (HJ IBC) cell technology enables remarkably high cell efficiencies, but requirescomplex processing for the rear-side patterning of the interdigitated a-Si:H electron and hole hetero-contacts. Therefore, the HJ IBC process flow must be simplified into a sequence that is cost-effective and industrially-compatible. Towards this goal, a litho-free, all-dry process sequence is being developed. As part of this simplified process flow, a novel in situ dry clean process called “nano-envelope” clean is developed to replace the wet cleaning after dry etching of a-Si:H. Surface contaminationanalysis and passivation studies prove that the developed dry clean is as effective as the standard wet clean. Since the “nano-envelope” clean can bedone in the same PECVD tool, the sequence from dry etching to repassivation can be done fully in situ.
Spectrogram Analysis of Genomes (2004)

We performed frequency-domain analysis in the genomes of various organisms using tricolor spectrograms, identifying several types of distinct visual patterns characterizing specific DNA regions. We relate patterns and their frequency characteristics to the sequence characteristics of the DNA. At times, the spectrogram patterns could be related to the structure of the corresponding protein region by using various public databases such as GenBank. Some patterns are explained from the biological nature of the corresponding regions, which relate to chromosome structure and protein coding, and some patterns have yet unknown biological significance. We found biologically meaningful patterns, on the scale of millions of base pairs, to a few hundred base pairs. Chromosome-wide patterns include periodicities ranging from 2 to 300. The color of the spectrogram depends on the nucleotide content at specific frequencies, and therefore can be used as a local indicator of CG content and other measures of relative base content. Several smaller-scale patterns were found to represent different types of domains made up of various tandem repeats.
Anandamide, a Natural Ligand for the Peripheral Cannabinoid Receptor Is a Novel Synergistic Growth Factor for Hematopoietic Cells (1997)

We recently demonstrated that the gene encoding the peripheral cannabinoid receptor (Cb2) may be a proto-oncogene involved in murine myeloid leukemias. We show here that Cb2 may have a role in hematopoietic development. RNAse protection analysis showed that Cb2 is normally expressed in spleen and thymus. Cb2 mRNA is also expressed in 45 of 51 cell lines of distinct hematopoietic lineages, ie, myeloid, macrophage, mast, B-lymphoid, T-lymphoid, and erythroid cells. The effect of the fatty acid anandamide, an endogenous ligand for cannabinoid receptors, on primary murine marrow cells and hematopoietic growth factor (HGF)-dependent cell lines was then investigated. In vitro colony cultures of normal mouse bone marrow cells showed anandamide to potentiate interleukin-3 (IL-3)-induced colony growth markedly. Whereas HGFs alone stimulate proliferation of the various cell lines in serum-free culture only weakly, anandamide enhances the proliferative response of the cell lines to HGFs profoundly. This was apparent for responses induced by IL-3, granulocyte-macrophage colony-stimulating factor, granulocyte colony-stimulating factor, and erythropoietin. Anandamide was already effective at concentrations as low as 0.1 to 0.3 micromol/L and plateau effects were reached at 0.3 to 3 micromol/L. The addition of anandamide as single growth factor had no effect. The costimulatory effect of anandamide was not evident when cells were cultured with fetal calf serum (FCS), suggesting that FCS contains anandamide or another ligand capable of activating the peripheral cannabinoid receptor. Other cannabinoid ligands did not enhance the proliferative responsiveness of hematopoietic cells to HGFs. Transfection experiments of Cb2 in myeloid 32D cells showed that anandamide specifically activates proliferation through activation of the peripheral cannabinoid receptor. Anandamide appears to be a novel and synergistic growth stimulator for hematopoietic cells.
Chronic Overexpression of Bradykinin in Kidney Causes Polyuria and Cardiac Hypertrophy (2018)

Acute intra-renal infusion of bradykinin increases diuresis and natriuresis via inhibition of vasopressin activity. However, the consequences of chronically increased bradykinin in the kidneys have not yet been studied. A new transgenic animal model producing an excess of bradykinin by proximal tubular cells (KapBK rats) was generated and submitted to different salt containing diets to analyze changes in blood pressure and other cardiovascular parameters, urine excretion, and composition, as well as levels and expression of renin-angiotensin system components. Despite that KapBK rats excrete more urine and sodium, they have similar blood pressure as controls with the exception of a small increase in systolic blood pressure (SBP). However, they present decreased renal artery blood flow, increased intrarenal expression of angiotensinogen, and decreased mRNA expression of vasopressin V1A receptor (AVPR1A), suggesting a mechanism for the previously described reduction of renal vasopressin sensitivity by bradykinin. Additionally, reduced heart rate variability (HRV), increased cardiac output and frequency, and the development of cardiac hypertrophy are the main chronic effects observed in the cardiovascular system. In conclusion: (1) the transgenic KapBK rat is a useful model for studying chronic effects of bradykinin in kidney; (2) increased renal bradykinin causes changes in renin angiotensin system regulation; (3) decreased renal vasopressin sensitivity in KapBK rats is related to decreased V1A receptor expression; (4) although increased renal levels of bradykinin causes no changes in mean arterial pressure (MAP), it causes reduction in HRV, augmentation in cardiac frequency and output and consequently cardiac hypertrophy in rats after 6 months of age.