gebhart/patrepeval huggingface dataset:
Grants, Funding, Awards and Recognition in Healthcare Innovation (2021)

For an idea to be validated, prototyped and tested, adequate financial planning plays a major role in the long journey of the idea from the brains to the market. There are various ways of getting funds for the startup. The founders usually start with their own money from their savings or some borrowings from family and friends which is called bootstrapping and is very common and crucial, akin to doctors starting their own clinics and small nursing homes. As they start to grow, large funds are needed in the early stage to set the foot firm with the help of an angel investor/ seed investor which is like starting a full-fledged hospital. The Venture capitalist comes in at a stage when the idea is proven and started with operations, early-stage customers and has a major potential to expand, just like when more branches of hospitals are planned. Private equity companies and investment banks are those who are keen to invest in companies who have proved themselves beyond doubt with strong leadership in the market and are looking for a major return on investment by making the company bigger, which is like planning a pan India network of the hospital chain. These investments happen multiple times or rounds at various stages of the company usually termed series A to series D or E and ultimately leading to the Initial Public Offering when it goes public from private holding. This funding journey is a well-planned effort quite specific to the investment stage, investor type, and their preferences. The recognition of the startups and their ideas plays a major role in them reaching to market and access to funding opportunities. The funding and national recognition from various govt. and private agencies such as BIRAC, FICCI, NASSCOM, Wellcome trust, and Villgro and international agencies such as CAMTech, Bill and Melinda gates foundation, Grand Challenges Canada, Stanford, and Harvard gives the much needed attention from the potential investors and is a major advantage which should be utilized well. Social media recognition plays a major role in recent times which has the potential to make an innovation “viral” and reach millions of customers and make relevant investors and govt. agencies notice, which can be a huge breakthrough for the company if the innovation has a social impact. We would like to make this article more practical, experiential, and contextual for better connect with pediatrician colleagues.
<title>Electrostatic interactions in micro-electro-mechanical resonant oscillators</title> (2001)

Resonant mode operation is common in many MicroElectroMechanical (MEM) applications including accelerometers, gyroscopes and filters [Kovacs (1998), Nguyen (1999)]. When electrostatic transduction is used in these applications, concerns about cross talk and fringing field effects due to geometry are major issues. In this paper, an electrostatically coupled system is briefly introduced, modeled and the dynamic response due to small parametric (displacement dependant) electrostatic force is analyzed using perturbation methods. The presence of coupled parametric resonance has a very significant effect on the dynamic response. Experimental verification of the occurrence of this phenomenon is also presented here. The coupled oscillator system can also be used as an in situ test device to understand the electrostatic parameters in a system. The method of modeling and analysis presented here is simple, yet captures the dynamic behavior of a system due to a small force. This method can be generalized and will be a useful tool in any resonant MEM system design.© (2001) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Steric and pH effects on the rate of Dakin oxidation of acylphenols (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSteric and pH effects on the rate of Dakin oxidation of acylphenolsM. B. Hocking, K. Bhandari, B. Shell, and T. A. SmythCite this: J. Org. Chem. 1982, 47, 22, 4208–4215Publication Date (Print):October 1, 1982Publication History Published online1 May 2002Published inissue 1 October 1982https://pubs.acs.org/doi/10.1021/jo00143a007https://doi.org/10.1021/jo00143a007research-articleACS PublicationsRequest reuse permissionsArticle Views1117Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Current capabilities for simulating the extreme distortion of thin structures subjected to severe impacts (1993)

The explicit transient dynamics technology in use today for simulating the impact and subsequent transient dynamic response of a structure has its origins in the 'hydrocodes' dating back to the late 1940's. The growth in capability in explicit transient dynamics technology parallels the growth in speed and size of digital computers. Computer software for simulating the explicit transient dynamic response of a structure is characterized by algorithms that use a large number of small steps. In explicit transient dynamics software there is a significant emphasis on speed and simplicity. The finite element technology used to generate the spatial discretization of a structure is based on a compromise between completeness of the representation for the physical processes modelled and speed in execution. That is, since it is expected in every calculation that the deformation will be finite and the material will be strained beyond the elastic range, the geometry and the associated gradient operators must be reconstructed, as well as complex stress-strain models evaluated at every time step. As a result, finite elements derived for explicit transient dynamics software use the simplest and barest constructions possible for computational efficiency while retaining an essential representation of the physical behavior. The best example of this technology is the four-node bending quadrilateral derived by Belytschko, Lin and Tsay. Today, the speed, memory capacity and availability of computer hardware allows a number of the previously used algorithms to be 'improved.' That is, it is possible with today's computing hardware to modify many of the standard algorithms to improve their representation of the physical process at the expense of added complexity and computational effort. The purpose is to review a number of these algorithms and identify the improvements possible. In many instances, both the older, faster version of the algorithm and the improved and somewhat slower version of the algorithm are found implemented together in software. Specifically, the following seven algorithmic items are examined: the invariant time derivatives of stress used in material models expressed in rate form; incremental objectivity and strain used in the numerical integration of the material models; the use of one-point element integration versus mean quadrature; shell elements used to represent the behavior of thin structural components; beam elements based on stress-resultant plasticity versus cross-section integration; the fidelity of elastic-plastic material models in their representation of ductile metals; and the use of Courant subcycling to reduce computational effort.
The treatment of sporadic versus MEN1‐related pituitary adenomas (2003)

The treatment of pituitary tumours strongly depends on their clinical presentation. In general, the treatment aims are reducing tumour volume and/or decreasing hormone hypersecretion. It relies on single or a combination of three different methods: surgery, medication and radiotherapy. The rationale for deciding the treatment are many but include the aggressiveness of the tumour. The aetiologies of sporadic pituitary adenomas are not fully understood. However, several causes have been identified resulting in specific familial phenotypes like multiple endocrine neoplasia type I (MEN1). MEN1 is related to mutations in the MEN1 gene, a tumour suppressor gene localized on chromosome 11q13 and which encodes menin, a 610 amino acid protein. During the last years, an evidence progressively emerged that MEN1-related adenomas were more aggressive and less responsive to therapy than their sporadic counterparts. In this article, we review the differences between sporadic and MEN1-related adenomas and suggest specific ways of treatment and follow-up for MEN1-related tumours.
Doped Carbon Nanotube Networks for Electrochemical Filtration of Aqueous Phenol: Electrolyte Precipitation and Phenol Polymerization (2012)

Electrochemical filtration with anodic carbon nanotube (CNT) networks is reported to be effective for chemical and microbiological water treatment. Here, we investigate how CNT doping affects the electrochemical filtration performance toward the remediation of aromatic wastewaters. Purified and well-characterized undoped (C-CNT), boron-doped (B-CNT), and nitrogen-doped (N-CNT) anodic carbon nanotube networks are challenged with aqueous phenol in a sodium sulfate electrolyte. Steady-state current and effluent total organic carbon (TOC) measurements are utilized to evaluate the oxidative performance as a function of voltage and electrolysis time. In terms of steady-state TOC removal, at an applied voltage of 3 V all three anodic CNT networks are able to remove approximately 7 to 8 mgC L(-1) of the influent TOC within the ~1 s liquid residence time of the electrochemical filter. The anodic CNT networks are partially passivated over the 5 h electrolysis time with the B-CNT network displaying the least passivation. The extent of passivation was observed to be inversely correlated to the CNT work function. SEM, XPS, and TGA of the electrolyzed CNT networks are used to identify the two primary passivation mechanisms of electrochemical phenols polymerization and electrochemical electrolyte precipitation. In agreement with chronoamperometry results, the B-CNT network has the lowest extent of passivating polymer and precipitate formation. The precipitant is determined to likely be sodium persulfate or carbonate and is removed with a simple acidic water wash. The polymer is determined to likely be polyphenylene oxide and is partially removed with the wash. All three anodic CNT networks display potential for energy efficient electrochemical filtration of aromatic wastewaters and the B-CNT are determined to be the most resistant to passivation.
Oligomerization of C/sub 3/-C/sub 4/ olefins using a novel nickel-aluminosilicate catalyst (1978)

Catalysts containing 9.7-14% nickel and 0.82-4% fluoride in layered-lattice synthetic mica-montmorillonite clay (NiSMM) were prepared, sulfided, and tested for the oligomerization of various butane-butene streams from a fluid catalytic cracker to gasoline and distillate boiling range materials. The reactions were conducted isothermally or adiabatically at 208/sup 0/-280/sup 0/F and 600 or 900 psi. The products showed that the NiSMM had good selectivity for a high octane isobutene dimer, catalyzed near-equilibrium isomerization of 1-butene to 2-butene without n-butene oligomerization, and converted butadiene to furnace oil boiling material. The potential commercial application of these reactions is as a complement to acid-catalyzed isobutane alkylation, in which isobutene gives poor alkylation products and has a very high acid consumption. The NiSMM catalyst also had a high selectivity for the conversion of propylene from propylene/alkane streams to give dimers and trimers of high octane value. The NiSMM catalyst showed good aging performance in the presence of high sulfur impurities, and was noncorrosive. Tables and 12 references.
Use of a Near UV Spatial Heterodyne Spectrometer for Interstellar [OII] Emission Line Studies: Characteristics, Calibration, and Atmospheric Foreground Characterization (2005)

This paper describes the use of a newly developed Spatial Heterodyne Spectrometer (SHS) designed to observe radial velocity resolved profiles of diffuse [OII] 3726 Å\ and 3729 Å\ emission lines from the warm (104 K), low-density (10-1 cm-3), ionized component of our Galaxy's interstellar medium (WIM). The [OII] SHS combines interferometric and field-widening gains to achieve sensitivities much larger than conventional grating instruments of similar size and resolving power, and comparable to the Wisconsin H\alpha Mapper (WHAM) Fabry-Perot, but in the near UV where WHAM cannot observe. The high spectral resolution and sensitivity of the SHS allowed us to spectrally isolate for the first time Galactic from terrestrial [OII] emission. We were able to identify the terrestrial [OII] foreground emission and other nearby airglow lines in directions toward very low intensity Galactic [OII] emission regions. The terrestrial [OII] \lambda3729/\lambda3726 line intensity ratio was measured to be 0.47 ±.05:1, compared to an emission ratio of 1.5:1 predicted (and observed) for the interstellar [OII] emission lines in the low density limit. Atmospheric foreground characterization, spectral calibration and absolute intensity calibration are discussed.
Expeditious Routes to Evernitrose and Vancosamine Derivatives and Synthesis of a Model Vancomycin Aryl Glycoside (1998)

Only seven steps are required to synthesize the activated derivatives 2 and 3 of evernitrose and vancosamine from the common intermediate 1 derived from L-lactic acid. The expeditious route to 3 was followed by its efficient incorporation into a vancomycin model system (4).
Line-defect calibration for line-scanning projection display (2009)

A method of line-defect calibration for line-scanning projection display is developed to accomplish acceptable display uniformity. The line scanning display uses a line modulating imaging and scanning device to construct a two-dimensional image. The inherent line-defects in an imaging device and optical lenses are the most fatal performance-degrading factor that should be overcome to reach the basic display uniformity level. Since the human eye recognizes line defects very easily, a method that perfectly removes line defects is required. Most line imaging devices are diffractive optical devices that require a coherent light source. This particular requirement makes the calibration method of sequential single pixel measurement and correction insufficient to take out the line defects distributed on screen due to optical crosstalk. In this report, we present a calibration method using a recursively converging algorithm that successfully transforms the unacceptable line-defected images into a uniform display image.
Dietary Intake of Vitamin D Is Related to Blood Levels of Advanced Glycation End Products during a Weight Loss Program in Obese Women (2016)

BACKGROUND/OBJECTIVES: Advanced glycation end products (AGEs) contribute to the pathophysiology of lifestyle-related diseases. To identify nutrients associated with AGEs, this study explored the factors by investigating the relationship between nutrients changes and changes of blood AGEs during a weight loss program in obese women. SUBJECTS/METHODS: Twenty-five obese women (age: 50 8 years, body mass index: 28.7 3.4 kg/m 2 ) underwent a weight loss program with energy-restricted meal replacement for 2 months. Three-day weighted dietary records and blood tests including blood AGEs were performed at the baseline and after the 2-month intervention. Their correlation was examined during the intervention period.
Transcription factors involved in terpenoid indole alkaloid biosynthesis in Catharanthus roseus (2007)

Plants produce alkaloids, among others, to protect themselves against microbial infection, herbivore attack or ultraviolet irradiation. For man, alkaloid metabolism is the source of many natural products with useful applications, including pharmaceuticals. A major mechanism regulating alkaloid production in plant cells is the control of the transcription of the biosynthetic genes. Several transcription factors involved in the regulation of alkaloid biosynthesis genes have been isolated and studied. There are indications that the abundance and activities of transcription factors themselves are regulated by external signals. The aim of this review is to give an update on the transcriptional regulation of terpenoid indole metabolism in Catharanthus roseus.
Supplementary Figure S3 from pVHL/HIF-Regulated CD70 Expression Is Associated with Infiltration of CD27<sup>+</sup> Lymphocytes and Increased Serum Levels of Soluble CD27 in Clear Cell Renal Cell Carcinoma (2023)

&lt;p&gt;&lt;i&gt;CD3&lt;/i&gt; subunits plotted against &lt;i&gt;CD27&lt;/i&gt; mRNA levels of the gene expression data. Results of Pearson R correlation analyses are depicted.&lt;/p&gt;
Dynamics in isolator-free injection-locked lasers (2009)

Dynamical behavior in injection-locked lasers without optical isolation between master and slave lasers is investigated. A uniquely new laser theory, that treats the two lasers on equal footing, predicts considerable modification to modulation response.
Supplementary Figure 4 from Aberrant Silencing of Cancer-Related Genes by CpG Hypermethylation Occurs Independently of Their Spatial Organization in the Nucleus (2023)

Supplementary Figure 4 from Aberrant Silencing of Cancer-Related Genes by CpG Hypermethylation Occurs Independently of Their Spatial Organization in the Nucleus
Properties of induced polarization evanescent reflection with a solid immersion lens (SIL) (2007)

Properties of the induced polarization signal with a solid immersion lens (SIL) are investigated by experiments and simulations. A LaSFN9 SIL (NA=1.5) is used in the experiment. Physics of the induced polarization signal are described for several configurations of optical systems and substrates. Induced polarization signals from evanescent-wave coupling to dielectric, semiconductor and metal substrates are studied in detail. It is shown that surface plasmon waves are excited with Au substrates and the induced polarization signal is affected by the surface plasmon waves. Simulation results of the induced polarization signal for a gallium phosphide SIL (NA=2.64) are discussed.
Alternative Locations for Internal Defibrillator Electrodes (1998)

Successful defibrillation is described in two patients in whom the defibrillating electrode was positioned in the coronary sinus and right ventricular outflow tract as alternative sites. Internal cardiac defibrillation has been successful with single or multiple endocardial electrodes, epicardial patch electrodes, and subcutaneous surface electrodes (patch, array) in varying combinations and recently with an active can electrode. While the traditional location of the endocardial electrode has been the right ventricular apex, we describe two patients in whom defibrillation was successful in alternate locations, the coronary sinus and the right ventricular outflow tract.
Improved Planar Amperometric Nitric Oxide Sensor Based on Platinized Platinum Anode. 2. Direct Real-Time Measurement of NO Generated from Porcine Kidney Slices in the Presence of l-Arginine, l-Arginine Polymers, and Protamine (2003)

Nitric oxide generation from porcine kidney slices is assessed using a new planar NO-selective amperometric sensor. The planar shape of the sensor allows for direct NO measurements near the surface (10 microm) of renal tissue slices in real time. Renal NO production may be modulated by the addition of L-arginine, arginine homopolymers (R2, R6, R10), and protamine, all of which can potentially transport across cellular membranes and provide a substrate for nitric oxide synthase within kidney parenchyma. Real-time amperometric measurements demonstrate that most L-arginine species can translocate across the cell membrane and rapidly increase NO production. However, no increase in NO generation is observed when the dimer of L-arginine (R2) is added to the solution bathing the tissue, suggesting that this species cannot permeate cell membranes. The degree of enhancement in NO generation observed for L-arginine and the larger peptides depends on the structure and follows the following sequence: R10 (decamer) > protamine > R6 (hexamer) > L-arginine. Protamine and the R10 decamer, especially, induce the largest increases in NO generation owing to their apparent rapid translocation into cells and subsequent cleavage by proteases to create high intracellular levels of L-arginine. The effect of sensor size (for sensor dimensions of 0.15- and 1-mm outer diameters) on the measured surface NO levels is also examined. The larger sensor traps more NO but hinders access of the L-arginine species to the tissue area between the flat distal plane of the sensor and the surface of the kidney slice. The use of such NO-generating peptides may be important in numerous biological systems that depend on NO production, such as ischemia-reperfusion injury and thrombogenesis.
Production of Polyacrylic Acid Homo‐ and Copolymer Films by Electrochemically Induced Free‐Radical Polymerization: Preparation and Swelling Behavior (2007)

Abstract Films of polyacrylic acid hydrogels were produced on a conducting substrate by means of electrochemically initiated polymerization (EIP). An electro‐chemical quartz crystal microbalance was used to monitor film growth in situ. Homopolymer and copolymer films of polyacrylic acid and poly‐ N ‐isopropylacrylamide were characterized by FTIR spectroscopy. The degree of swelling of these films could be tuned via the pH.
Improvement on the Strength of 6063 Aluminum Alloy by Means of Warm Rolling Operation (2018)

This paper presents the effect of varying processing variables on the superplastic ductility of Al 6063 alloy. The three variables investigated were total strain, reheating time and strain rate during warm rolling (by varying the reduction per pass). The alloy samples were warm rolled at strain rates varying from 1.0 x 10-5s-1 to 4.1 x 10-1s-1 to a total true strain of 3, at 4.4 – 7.5% reduction per pass for 3 hours reheating time between passes. Tensile test and microstructural analysis were carried out on the samples. The results showed that at lowest strain rate (4.1 x 10-3s-1), greatest ductility, fracture stress and fracture energy were achieved with 4.0% reduction pass. The material warm rolled to a total true strain of 2.9 exhibited much higher ductility. Longer reheating time revealed coarser grains, with peak ductility occurring at slower strain rates.
Dyspnoea after AZD6140: safety first? (2006)

Husted et al. 1 published dose-finding Phase 2 randomized study comparing novel oral reversible platelet P2Y12 antagonist, AZD6140, with conventional clopidogrel on top of low-dose aspirin. The authors should be acknowledged for the thoughtful design, detailed analysis, well-balanced opinions, and perfect timing for such work to appear. Indeed, the era of expanding antiplatelet regimens and indications may require new agents as the substitutes or additions to the available strategies. However, the alarming frequency of dyspnoea reported …