gebhart/patrepeval huggingface dataset:
α‐Santalol, A Skin Cancer Chemopreventive Agent with Potential to Target Various Pathways Involved in Photocarcinogenesis (2013)

This study is designed to investigate the chemopreventive effect and molecular mechanisms of α-santalol on UVB-induced skin tumor development in SKH-1 hairless mouse, a widely used model for human photocarcinogenesis. A dose of UVB radiation (30 mJ cm(-2) day(-1)) that is in the range of human sunlight exposure was used for the initiation and promotion of tumor. Topical treatment of mice with α-santalol (10%, wt/vol in acetone) caused reduction in tumor incidence, multiplicity and volume. In our study, the anticarcinogenic action of α-santalol against UVB-induced photocarcinogenesis was found to be associated with inhibition of inflammation and epidermal cell proliferation, cell cycle arrest and induction of apoptosis. α-Santalol pretreatment strongly inhibited UVB-induced epidermal hyperplasia and thickness of the epidermis, expression of proliferation and inflammation markers proliferating cell nuclear antigen (PCNA), Ki-67 and cyclooxygenase 2 (Cox-2). Significant decrease in the expression of cyclins A, B1, D1 and D2 and cyclin-dependent kinases (Cdk)s Cdk1 (Cdc2), Cdk2, Cdk4 and Cdk6 and an upregulated expression of cyclin-dependent kinase (CDK) inhibitor Cip1/p21 were found in α-santalol pretreated group. Furthermore, an elevated level of cleaved caspase 3 and cleaved poly (ADP-ribose) polymerase (PARP) were observed in α-santalol-treated group. Our data suggested that α-santalol is a safer and promising skin cancer chemopreventive agent with potential to target various pathways involved in photocarcinogenesis.
Formal Approaches to Understanding Biological Oscillators (1993)

In this brief review, we have attempted to illustrate the utility of our qualitative scheme proposed in 1984 (27). This scheme provides a means of summarizing information concerning oscillating systems by identifying system variables and parameters and the interactions between variables. Moreover, the qualitative scheme can be employed to deduce the form of system differential equations. This second step then clearly shows the rate constants that must be deduced through experimentation for the construction of explicit mathematical models.
A novel genetic leukocyte adhesion deficiency in subsecond triggering of integrin avidity by endothelial chemokines results in impaired leukocyte arrest on vascular endothelium under shear flow (2003)

Leukocyte arrest on vascular endothelium under disruptive shear flow is a multistep process that requires in situ integrin activation on the leukocyte surface by endothelium-displayed chemoattractants, primarily chemokines. A genetic deficiency of leukocyte adhesion to endothelium associated with defective beta2 integrin expression or function (LAD-1) has been described. We now report a novel severe genetic disorder in this multistep process associated with functional defects in multiple leukocyte integrins, reflected in recurrent infections, profound leukocytosis, and a bleeding tendency. This syndrome is associated with an impaired ability of neutrophil and lymphocyte beta1 and beta2 integrins to generate high avidity to their endothelial ligands and arrest cells on vascular endothelium in response to endothelial chemoattractant signals. Patient leukocytes roll normally on endothelial selectins, express intact integrins and G protein-coupled chemokine receptors (GPCR), spread on integrin ligands, and migrate normally along a chemotactic gradient. Activation of beta2 integrins in response to GPCR signals and intrinsic soluble ligand binding properties of the very late activation antigen-4 (VLA-4) integrin are also retained in patient leukocytes. Nevertheless, all integrins fail to generate firm adhesion to immobilized ligands in response to in situ GPCR-mediated activation by chemokines or chemoattractants, a result of a primary defect in integrin rearrangement at ligand-bearing contacts. This syndrome is the first example of a human integrin-activation deficiency associated with defective GPCR stimulation of integrin avidity at subsecond contacts, a key step in leukocyte arrest on vascular endothelium under shear flow.
Totally Phospholipidic Mesoporous Particles (2015)

Medical science is one of the areas where mesoporous materials can offer important advances despite the stringent safety requirements for potentially useful materials. Here we report totally phospholipidic mesoporous particles which may be used as a novel drug carrier. This material is anticipated to be safe for human internal use since it is composed solely of phosphatidylcholine (PC) which is a major component of biological membranes and is approved for use in humans by the US Food and Drug Administration (FDA). We have established a simple production methodology of mesoporous phospholipid particles (MPPs) in which PC is dissolved in two-component solvent mixtures, followed by incubation of the resulting solutions at depressed temperatures, which induces liquid–liquid demixing and leads to the agglomeration of PC as spherical particles. A mesoporous form was then obtained by removing ice crystals through freeze-drying of the particles. MPP could accommodate both hydrophilic and hydrophobic guest molecules in the lamellar structure and the mesopores. It might be applied as a novel drug carrier in a complementary or even a replacement technology of liposomes.
The pressure wave field of an air gun array (1984)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1984The pressure wave field of an air gun arrayAuthors: A. ZiolkowskiG. MetselaarA. ZiolkowskiDelft Univ. of Technology, Netherlands and G. MetselaarDelft Univ. of Technology, Netherlandshttps://doi.org/10.1190/1.1893958 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1893958FiguresReferencesRelatedDetailsCited byInternational Airgun Modeling Workshop: Validation of Source Signature and Sound Propagation Models—Dublin (Ireland), July 16, 2016—Problem DescriptionIEEE Journal of Oceanic Engineering, Vol. 44, No. 3What controls the initial peak of an air-gun source signature?Leighton M. Watson, Jonatan Werpers, and Eric M. Dunham8 March 2019 | GEOPHYSICS, Vol. 84, No. 2Viscosity in air-gun bubble modelingJack King18 November 2015 | GEOPHYSICS, Vol. 81, No. 1Air-gun bubble-ghost interactionsJack R. C. King15 October 2015 | GEOPHYSICS, Vol. 80, No. 6High-speed photography of the bubble generated by an airgun1Geophysical Prospecting, Vol. 44, No. 1 SEG Technical Program Expanded Abstracts 1984ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1984 Pages: 856 publication data© 1984 Copyright © 1984 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 24 Mar 2005 CITATION INFORMATION A. Ziolkowski and G. Metselaar, (1984), "The pressure wave field of an air gun array," SEG Technical Program Expanded Abstracts : 274-276. https://doi.org/10.1190/1.1893958 Plain-Language Summary PDF DownloadLoading ...
SSCP polymorphism in the human hepatic triglyceride lipase (LIPC) gene (1992)

Journal Article SSCP polymorphism in the human hepatic triglyceride lipase (LIPC) gene Get access M. Reina, M. Reina Department of Medicine, University of Washington, Seattle, WA 98195USA Search for other works by this author on: Oxford Academic PubMed Google Scholar S. Deeb S. Deeb * Department of Medicine, University of Washington, Seattle, WA 98195USA * To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Human Molecular Genetics, Volume 1, Issue 6, September 1992, Page 453, https://doi.org/10.1093/hmg/1.6.453-a Published: 01 September 1992
650 nm 적색광의 여드름 치료효과 (2010)

Background: With the emergence of problems with conventional acne vulgaris treatments, the demand for safe and effective treatment has been increasing. Recently, many studies have shown that phototherapy can be an alternative treatment for acne. Objective: This study was designed to investigate the efficacy and safety of red light phototherapy for mild to moderate acne vulgaris. Methods: Thirty-nine patients with mild to moderate facial acne vulgaris were recruited. The patients were instructed to use an ordinary light emitting diode (LED)-attached device on left facial acne and a red light-emitting device on right facial acne for 16 minutes, twice a day, for 6 weeks. Acne was assessed at baseline and at weeks 2, 4, and 6. Results: A significant reduction of Burton scale and lesion count was observed on the red light emitting side, compared with the LED-emitting side. Improvement of satisfaction of patients and efficacy assessment on the red light emitting side were 82.05% and 84.62%, respectively, compared with 41.03% and 38.46%, respectively, on the LED emitting side. One patient complained of cheilitis, but it was temporary. Conclusion: This study shows that 650 nm red light therapy can be an effective and safe treatment for mild to moderate acne vulgaris. (Korean J Dermatol 2010;48(2):101∼108)
Taking Fingerprints of DNA Polymerases: Multiplex Enzyme Profiling on DNA Arrays (2009)

A novel screening approach based on an oligonucleotide-addressing enzyme assay enables multiplexed simultaneous profiling of DNA polymerases in nanoliter volumes in terms of their different properties. This approach was used to identify enzymes with altered properties out of a library of protein mutants.
Intravenous azlocillin kinetics in patients on long-term hemodialysis (1980)

The kinetics of the antipseudomonas penicillin, azlocillin, was studied after intravenous injection in 9 patients with creatinine clearance under 7 ml/min. All were on long-term hemodialysis; 3 were also studied during a dialysis-free period. Kinetic parameters were derived using a 2-compartment open model. The mean serum azlocillin half-life (t 1/2) was 1.93 hr in patients on dialysis and approximately 5 hr off dialysis. Thirty percent of the dose was recovered in the dialysate during a 4-hr period. An approach to the use of azlocillin in patients undergoing dialysis is presented.
Role of plasmid-encoded adherence factors in adhesion of enteropathogenic Escherichia coli to HEp-2 cells (1987)

Plasmid-encoded adherence factors have been shown to be important for the full expression of enteropathogenic Escherichia coli (EPEC) pathogenicity and for EPEC adhesion to cultured HEp-2 cells. EPEC strain E2348 (O127) shows localized HEp-2 cell adhesion and possesses a 60-megadalton plasmid, pMAR2. When E2348 is cured of pMAR2 it loses the ability to adhere to HEp-2 cells, while nonadherent E. coli K-12 strains P678-54 and HB101 acquire HEp-2 adhesiveness after they gain the plasmid. By electron microscopy, E2348 was seen to adhere to HEp-2 cells in a manner that closely resembled EPEC adhesion to intestinal mucosa; bacteria were intimately attached to projections of the apical HEp-2 cell membrane and caused localized destruction of microvilli. The plasmid-containing K-12 strains, on the other hand, did not show intimate attachment and there was no modification of cell surface architecture. It is concluded that plasmid pMAR2 codes for an adhesin, possibly fimbrial in nature, that promotes HEp-2 adhesion but that other chromosomally encoded factors are required for EPEC to achieve the characteristic mode of intimate cell attachment.
Analysis of tissue specific progenitor cell differentiation using FT-IR (2007)

Tissue specific progenitor cells and its differentiations have got a lot of attentions in regenerative medicine. The process of differentiations, the formation of tissues, has become better understood by the study using a lot of cell types progressively. These studies of cells and tissue dynamics at molecular levels are carried out through various approaches like histochemical methods, application of molecular biology and immunology. However, in case of using regenerative sources (cells, tissues and biomaterials etc.) clinically, they are measured and quality-controlled by non-contact and non-destructive methods from the view point of safety. Or the analysis with small quantities of materials could be possible if the quantities of materials are acceptable. A non-contact and non-destructive quality control method has been required. Recently, the use of Fourier Transform Infrared spectroscopy (FT-IR) has been used to monitor biochemical changes in cells, and has gained considerable importance. The changes in the cells and tissues, which are subtle and often not obvious in the histpathological studies, are shown to be well resolved using FT-IR. Moreover, although most techniques designed to detect one or a few changes, FT-IR is possible to identify the changes in the levels of various cellular biochemicals simultaneously under in vivo and in vitro conditions. The objective of this study is to establish the infrared spectroscopy of tissue specific progenitor cell differentiations as a quality control of cell sources for regenerative medicine. In the present study, as a basic study, we examine the adipose differentiation kinetics of preadipose cells (3T3-L1) and the osteoblast differentiation kinetics of mesenchymal stem cells (Kusa-A1) to analyze the infrared absorption spectra.
Corrosion Rate Measurement by Hydrogen Effusion In Dynamic Aqueous Systems At Elevated Temperature and Pressure (1959)

A method of applying the hydrogen effusion method to the measurement of corrosion rates in dynamic aqueous systems at elevated temperature and pressure is described. Data obtained in low carbon steel systems are presented, including (1) reproducibility obtained in measured hydrogen effusion rates at a flow velocity of 1 foot per second at a temperature of 600 F and 2000 psi, and (2) a quantitative comparison between the hydrogen effusion rates in static and in low flow velocity dynamic systems at this temperature and pressure. Some observations are included on corrosion rate measurements in a high flow velocity (30 feet per second) loop by the hydrogen effusion method. Implications of these measurements with regard to the comparison between high flow velocity corrosion and low flow velocity corrosion are mentioned and some data indicating high local sensitivity of the hydrogen effusion method are noted. Some possible difficulties involved in the method are pointed out. 2.3.4
Urokinase Plasminogen Activator Is a Central Regulator of Macrophage Three-Dimensional Invasion, Matrix Degradation, and Adhesion (2014)

Urokinase plasminogen activator (uPA) and its receptor (uPAR) coordinate a plasmin-mediated proteolytic cascade that has been implicated in cell adhesion, cell motility, and matrix breakdown, for example, during inflammation. As part of their function during inflammatory responses, macrophages move through tissues and encounter both two-dimensional (2D) surfaces and more complex three-dimensional (3D) interstitial matrices. Based on approaches employing uPA gene-deficient macrophages, plasminogen supplementation, and neutralization with specific protease inhibitors, it is reported in this study that uPA activity is a central component of the invasion of macrophages through a 3D Matrigel barrier; it also has a nonredundant role in macrophage-mediated matrix degradation. For murine macrophages, matrix metalloproteinase-9 activity was found to be required for these uPA-mediated effects. Evidence for a unique role for uPA in the inverse relationship between macrophage adhesion and 2D migration was also noted: macrophage adhesion to vitronectin was enhanced by uPA and blocked by plasminogen activator inhibitor-1, the latter approach also able to enhance in turn the 2D migration on this matrix protein. It is therefore proposed that uPA can have a key role in the inflammatory response at several levels as a central regulator of macrophage 3D invasion, matrix remodeling, and adhesion.
Modeling User Feedback: Fuzzy sampling, Portability, and Degree of Annoyance (2020)

User feedback is an important aspect of any social platform. The platform needs to adapt based on user preferences, eliminating the need for user input over time. This paper describes the experimentation with feedback received from users on their comfort level with temperatures in their work environment. The building energy management system will adapt itself so that users do not need to adjust the temperatures. This study addresses a number of issues with the user feedback modeling including managing a data imbalance with the help of fuzzy clustering, ability to transfer the user models between rooms and across different buildings, as well as, predicting a degree of discomfort. The experiments are based on user feedback collected from two commercial buildings.
ISOTOPIC MICROASSAY OF HISTAMINE, HISTIDINE, HISTIDINE DECARBOXYLASE AND HISTAMINE METHYLTRANSFERASE IN BRAIN TISSUE1 (1972)

Abstract— Microassays are described for histamine, histidine, and the activities of the enzymes histidine decarboxylase (EC 4.1.1.22) and histamine niethyltransferase (EC 2.1.1.8) in brain tissue. The enzymic‐isotopic microassay for histamine is based on the methylation of tissue histamine by added histamine methyl‐transferase and [ 14 C]‐ or [ 3 H]‐labelled S ‐adenosyl‐ l ‐methionine. In a double‐isotopic form of the assay, a tracer of [ 3 H]histamine is employed along with [ 14 C] S ‐adenosyl‐ l ‐methionine, and the ratio [ 14 C]:[ 3 H] reflects the amount of histamine in the sample. Because the methylation of histamine is uniform in brain samples studied, a single isotopic assay with [ 3 H] S ‐adenosyl‐ l ‐methionine as the methyl donor is possible and increases sensitivity, so that 10 pg of tissue histamine can be estimated reliably. The assay for histidine involves decarboxylation of histidine by a bacterial histidine decarboxylase and measurement of the histamine formed by the enzymicisotopic procedure. In the histidine decarboxylase assay, histamine synthesized from added histidine is measured. The assay for histamine methyltransferase involves measuring the formation of [ 14 C]methylhistamine with [ 14 C] S ‐adenosyl‐ l ‐methionine serving as the methyl donor.
Supplementary Table S1 from SHOC2 Is a Critical Modulator of Sensitivity to EGFR–TKIs in Non–Small Cell Lung Cancer Cells (2023)

&lt;p&gt;A list of sgRNAs in a small-scale custom library&lt;/p&gt;
Velocity trajectory optimization in Hybrid Electric trucks (2010)

Hybrid Electric Vehicles (HEVs) enable fuel savings by re-using kinetic and potential energy that was recovered and stored in a battery during braking or driving down hill. Besides, the vehicle itself can be seen as a storage device, where kinetic energy can be stored and retrieved by changing the forward velocity. It is beneficial for fuel consumption to optimize the velocity trajectory in two ways; i) to assist the driver in tracking an optimal velocity trajectory (e.g. input to an Adaptive Cruise Controller); ii) to estimate the future power request trajectory which can be used to optimize the hybrid components use. Taking advantage of satellite navigation, together with the vehicles current mass and road load parameters, an optimization problem is formulated, and solved for a driver defined time constraint. Despite tight velocity constraints, this can result in 5% fuel saving compared to a Cruise Controller with constant velocity setpoint. The benefit of velocity trajectory optimization is indicated with experimental results.
Thermogenesis and BAT activity in hypophysectomized rats with and without corticotropin replacement (1985)

Surgical hypophysectomy (Hypox) suppressed body weight, body energy gain, and net energetic efficiency when compared with pair-fed, sham-operated controls but caused marked increases in the thermic response to food, brown adipose tissue (BAT) mass, protein content, and BAT thermogenic activity (estimated from mitochondrial purine nucleotide binding). Chronic replacement of Hypox rats with ACTH restored adrenal weight, plasma corticosterone levels, body energy gain, energetic efficiency, and the thermic response to food to normal. However, the Hypox-replaced animals were apparently fatter (greater carcass energy density) and retained a greater mass of brown fat than controls. Purine nucleotide binding to BAT mitochondria was lower in the ACTH-replaced group than in Hypox rats but remained above the level in controls. These data indicate that hypophysectomy stimulates thermogenesis, probably as a result of decreased adrenal steroid release. However, ACTH does not totally prevent the effects of Hypox, and an involvement of other pituitary hormones and/or hypothalamic-releasing factors cannot be excluded.
Beta(β)3‐adrenergic receptors in human pancreatic islet and duodenal somatostatin neuroendocrine cells (2000)

We have identified a population of neuroendocrine cells in the human pancreas and duodenum that express beta3-adrenergic receptors. These cells appear to be somatostatin D cells.
A Low-Power and High-Precision Programmable Analog Filter Bank (2012)

Analog filter banks befit remote audio- and vibration-sensing applications, which require frequency analysis to be performed with low-power consumption and with moderate-to-high precision. The precision of a filter bank depends on both the signal-path precision (i.e., dynamic range) and also the parameter precision (e.g., accuracy of the center frequencies). This brief presents a new bandpass filter for audio-frequency filter banks and provides a procedure for designing this filter. The filter is used in a 16-channel filter bank which has been fabricated in a 0.35- CMOS process. This filter bank has a dynamic range exceeding 62 dB and consumes only 63.6 when biased for speech frequencies. The filter bank's parameters are set via floating-gate current sources. This brief shows how to use these floating gates to obtain a versatile filter bank that can be precisely reprogrammed to arbitrary filter spacings and frequency weightings, with a parameter accuracy exceeding 99%.
Paper‐Origami‐Based Multiplexed Malaria Diagnostics from Whole Blood (2016)

We demonstrate, for the first time, the multiplexed determination of microbial species from whole blood using the paper-folding technique of origami to enable the sequential steps of DNA extraction, loop-mediated isothermal amplification (LAMP), and array-based fluorescence detection. A low-cost handheld flashlight reveals the presence of the final DNA amplicon to the naked eye, providing a "sample-to-answer" diagnosis from a finger-prick volume of human blood, within 45 min, with minimal user intervention. To demonstrate the method, we showed the identification of three species of Plasmodium, analyzing 80 patient samples benchmarked against the gold-standard polymerase chain reaction (PCR) assay in an operator-blinded study. We also show that the test retains its diagnostic accuracy when using stored or fixed reference samples.