gebhart/patrepeval huggingface dataset:
Modeling and control tuning of a hydro station with units sharing a common penstock section (1999)

Modeling of hydro plants in which multiple units share a common conduit was examined and a model was derived for simulation of such plants including cases where units of different size are present. The nature of the plant response is examined through simulations to explain the relationships of the physical parameters. Turbine/governor parameter settings and their relation to hydraulic coupling effects is discussed. The effects of parameter settings on plant stability under island or black start conditions is discussed and demonstrated via simulations.
Global identification of alternative splicing via comparative analysis of SMRT‐ and Illumina‐based RNA‐seq in strawberry (2016)

Alternative splicing (AS) is a key post-transcriptional regulatory mechanism, yet little information is known about its roles in fruit crops. Here, AS was globally analyzed in the wild strawberry Fragaria vesca genome with RNA-seq data derived from different stages of fruit development. The AS landscape was characterized and compared between the single-molecule, real-time (SMRT) and Illumina RNA-seq platform. While SMRT has a lower sequencing depth, it identifies more genes undergoing AS (57.67% of detected multiexon genes) when it is compared with Illumina (33.48%), illustrating the efficacy of SMRT in AS identification. We investigated different modes of AS in the context of fruit development; the percentage of intron retention (IR) is markedly reduced whereas that of alternative acceptor sites (AA) is significantly increased post-fertilization when compared with pre-fertilization. When all the identified transcripts were combined, a total of 66.43% detected multiexon genes in strawberry undergo AS, some of which lead to a gain or loss of conserved domains in the gene products. The work demonstrates that SMRT sequencing is highly powerful in AS discovery and provides a rich data resource for later functional studies of different isoforms. Further, shifting AS modes may contribute to rapid changes of gene expression during fruit set.
Fludarabine and cyclophosphamide with filgrastim support in patients with previously untreated indolent lymphoid malignancies (2000)

To evaluate the response rate and potential toxicities, a phase II trial was conducted of fludarabine and cyclophosphamide with filgrastim support in patients with previously untreated low-grade and select intermediate-grade lymphoid malignancies. Symptomatic patients with preserved end organ function received cyclophosphamide 600 mg/m(2) intravenous (iv) day 1 and fludarabine 20 mg/m(2) iv days1 through 5, followed by filgrastim 5 microg/kg subcutaneous starting approximately day 8. Treatment was repeated every 28 days until maximum response or a maximum of 6 cycles. Sixty patients, median age 53.5 years, were enrolled. Thirty-seven patients with non-Hodgkin lymphoma (NHL) were stage IV and 6 were stage III. Eleven of 17 patients with chronic lymphocytic leukemia (CLL) were Rai intermediate risk and 6 were high risk. The overall complete response (CR) rate was 51% and the partial response (PR) rate was 41%. Of patients with CLL, 47% achieved a CR and the remaining 53% achieved a PR. Of patients with follicular lymphoma, 60% achieved CR and 32% achieved a PR. Although the toxicity of this regimen was mainly hematologic, significant nonhematologic toxicities, including infections, were seen. Twenty-four patients subsequently received an autologous or allogeneic stem cell transplant. Engraftment was rapid, and there were no noticeable procedure toxicities in the immediate posttransplant period attributable to the fludarabine and cyclophosphamide regimen. Fludarabine, cyclophosphamide, and filgrastim make up a highly active and well-tolerated regimen in CLL and NHL.
Dissolution Flowsheet for U-10Mo Scrap Generated from the Fabrication of High Performance Research Reactor Fuel (2019)

The Savannah River National Laboratory was requested to develop dissolution flowsheets for low enriched uranium scrap streams generated during the fabrication of high performance research reactor (HPRR)fuel. The scrap streams include U-10Mo-Zr foil and rejected Al-clad plates. Co-rolled U-10Mo-Zr foils and Alclad U-10Mo-Zr mini-plates which have been through the hot isostatic pressing process were obtained from BWX Technologies, Inc. for use in this work. Small-scale dissolution experiments were performed to identify the flowsheet conditions required to safely and efficiently dissolve the fuel fabrication scrap for subsequent U recovery. Experiments were performed to demonstrate the dissolution of the U-10Mo-Zr foil, removal of the Al cladding from the mini-plates, and the dissolution of the mini-plates following cladding removal.
Adaptive radiotherapy for head and neck cancer (2018)

ART may decrease toxicity and improve local control for locally advanced HNC. However, randomized trials are necessary to demonstrate the benefit of ART before using the technique in routine practice.
Detection and genetic characterisation of van A‐containing Enterococcus strains in healthy Lusitano horses (2010)

Lusitano horses were investigated in order to detect the presence of vancomycin-resistant enterococci. vanA isolates showed high level vancomycin (Minimum inhibitory concentration; MIC > or = 128 mg/l) and teicoplanin resistance (MIC 64 mg/l), as well as resistance to ciprofloxacin, erythromycin and tetracycline. The tet(L) and erm(B) genes, associated with tetracycline and erythromycin resistance, respectively, were found in all vanA isolates. The intestinal tract of Lusitano horses can be a potential reservoir for vanA-containing enterococci.
AI in 6G: Energy-Efficient Distributed Machine Learning for Multilayer Heterogeneous Networks (2022)

Adept network management is key for supporting extremely heterogeneous applications with stringent quality of service (QoS) requirements; this is more so when envisioning the complex and ultra-dense 6G mobile heterogeneous network (HetNet). From both the environmental and economical perspectives, non-homogeneous QoS demands obstruct the minimization of the energy footprints and operational costs of the envisioned robust networks. As such, network intelligentization is expected to play an essential role in the realization of such sophisticated aims. The fusion of artificial intelligence (AI) and mobile networks will allow for the dynamic and automatic configuration of network functionalities. Machine learning (ML), one of the backbones of AI, will be instrumental in forecasting changes in network loads and resource utilization, estimating channel conditions, optimizing network slicing, and enhancing security and encryption. However, it is well known that ML tasks themselves incur massive computational burdens and energy costs. To overcome such obstacles, we propose a novel layer-based HetNet architecture which optimally distributes tasks associated with different ML approaches across network layers and entities; such a HetNet boasts multiple access schemes as well as device-to-device (D2D) communications to enhance energy efficiency via collaborative learning and communications.
c-Myb prevents TPA-induced differentiation and cell death in v-Myb transformed monoblasts. (1994)

Myelomonocytic cells transformed by v-Myb or altered forms of c-Myb do not contain the full-length c-Myb protein found in most immature hematopoietic cells. To determine if c-Myb was a dominant inhibitor of v-Myb, we have induced the synthesis of full-length c-Myb in monoblasts transformed by v-Myb. We found that although some morphological changes occurred, the presence of both c-Myb and v-Myb was compatible with cell growth. However, the response to phorbol ester (TPA) was significantly altered by c-Myb. Monoblasts transformed by v-Myb can be induced to differentiate into macrophages by treatment with TPA. This process is accompanied by a significant amount of cell death. However, when c-Myb was made TPA-inducible in these cells, TPA-induced differentiation into macrophages was blocked and cell death was prevented. These results demonstrate a significant difference in the biological effects of v-Myb and c-Myb in transformed myelomonocytic cells.
Marek's disease virus associated ocular lymphoma in Roulroul partridges (Rollulus rouloul) (2015)

Two 1-year old Roulroul partridges (Rollulus rouloul), one male and one female, were presented because of eye problems and anorexia. Twenty of the 30 Roulroul partridges in the owner's collection had already died. The affected birds stopped eating, became thinner, and eventually died. Antibiotic treatment, which started because of the suspicion of a septicaemic process, was unsuccessful. At clinical examination of the two partridges it was found that in both birds, one eye ball was filled with a whitish yellow amorphous material and the other eye ball of the female showed a distinct corneal opacity. Both presented birds were euthanized. Necropsy revealed no significant abnormalities in addition to the eye lesions. Histology and immunohistochemistry of the female's eye revealed an infiltrate of T-lymphocytes corresponding to ocular lymphoma. Herpesvirus genus-specific PCR, followed by Sanger sequencing confirmed the presumptive diagnosis of Marek's disease in both birds. To our knowledge, this is the first confirmed case of infection with Gallid Herpesvirus 2 (Marek's disease virus) in partridges and the first case in this specific species.
Endoplasmic reticulum stress response and bile acid signatures associate with multi-strain seroresponsiveness during elderly influenza vaccination (2021)

The elderly are an important target for influenza vaccination, and the determination of factors that underlie immune responsiveness is clinically valuable. We evaluated the immune and metabolic profiles of 205 elderly Singaporeans administered with Vaxigrip. Despite high seroprotection rates, we observed heterogeneity in the response. We stratified the cohort into complete (CR) or incomplete responders (IR), where IR exhibited signs of accelerated T cell aging. We found a higher upregulation of genes associated with the B-cell endoplasmic-reticulum stress response in CR, where XBP-1 acts as a key upstream regulator. B-cells from IR were incapable of matching the level of XBP-1 upregulation observed in CR after inducing ER stress with tunicamycin <i>in vitro</i>. Metabolic signatures also distinguished CR and IR - as CR presented with a greater diversity of bile acids. Our findings suggest that the ER-stress pathway activation could improve influenza vaccination in the elderly.
Noncontiguous operon is a genetic organization for coordinating bacterial gene expression (2019)

Bacterial genes are typically grouped into operons defined as clusters of adjacent genes encoding for proteins that fill related roles and are transcribed into a single polycistronic mRNA molecule. This simple organization provides an efficient mechanism to coordinate the expression of neighboring genes and is at the basis of gene regulation in bacteria. Here, we report the existence of a higher level of organization in operon structure that we named noncontiguous operon and consists in an operon containing a gene(s) that is transcribed in the opposite direction to the rest of the operon. This transcriptional architecture is exemplified by the genes <i>menE-menC</i>-<i>MW1733</i>-<i>ytkD-MW1731</i> involved in menaquinone synthesis in the major human pathogen <i>Staphylococcus aureus</i> We show that <i>menE-menC</i>-<i>ytkD-MW1731</i> genes are transcribed as a single transcription unit, whereas the <i>MW1733</i> gene, located between <i>menC</i> and <i>ytkD</i>, is transcribed in the opposite direction. This genomic organization generates overlapping transcripts whose expression is mutually regulated by transcriptional interference and RNase III processing at the overlapping region. In light of our results, the canonical view of operon structure should be revisited by including this operon arrangement in which cotranscription and overlapping transcription are combined to coordinate functionally related gene expression.
A Dual-modal, Dual-channel, Mesoscopic-scale Theranostic Endoscope for Quantitative Imaging, Monitoring, and Light-triggering of Chemodrug Release from Liposomes in Vivo (2018)

We present a dual-modal, dual-channel, mesoscopic flexible endoscope that allows quantitative reflectance and fluorescence imaging for quantitative imaging, light delivery and monitoring of local drug concentrations in an ovarian cancer model in mice.
ROSETTA - Surface Science Package - Integrated Microelectronics Study (1994)

This report shows the benefits resulting from the application of advanced microelectronics packaging technologies to the Comet rendezvous mission (ROSETTA). It mainly concentrates on the NASA/JPL 'Surface Science Package' for this ESA cornerstone mission to be launched in 2003. The principles and technologies approaches are also applicable to future small satellite mission designs. (orig.)
Synthesis and Physiological Activity of Hydroxyaryl Isoxazoles (1972)

Department of Chemistry, Osmania University, Hyderabad-7 <em>Received </em><em>11 May 1972</em> The synthesis of a few 3-<em>α</em>-hydroxy-<em>β</em>-naphthyl and 3-(4-hydroxy-3-biphenylyl-5-aryl isoxazoles has been carried out for elucidating the antibacterial and antifungal properties. The chalcone dibromide method has been utilised for making these compounds. Among the compounds tested, 3-<em>α</em>-hydroxy-<em>β</em>-naphthl-5-0-methoxyphenyl isoxazole exhibited the maximum activity to both bacteria and fungii.
IPv6 Network Management Planning (2013)

This chapter discusses IPv6 network management considerations in the context to FCAPS, including corollary functions like inventory tracking, address management, configuration databases, and release and change management as well within appropriate contexts. It starts with the “configuration” component, specifically inventory and address management, since these functions are critical to defining the scope for the other FCAPS functions. Next, the chapter talks about simple network management protocol (SNMP), which defines an overall information hierarchy for managed information while management information bases (MIBs) define the structure of information objects or variables for a given set of metrics. Most organizations document standardized methods and procedures (M&Ps) for provisioning, monitoring, testing, and diagnosing computing or network equipment. The testing prephase of production deployment affords a good opportunity for refining M&P documentation.
Methanol Adsorption on HKUST-1 Coatings Obtained by Thermal Gradient Deposition (2016)

Adsorption-driven heat transformation has been reported as one of the most promising areas to bring metal–organic frameworks (MOFs) into industrial application. The vast majority of evaluated systems apply water as the working fluid. Since the use of water comes with many drawbacks, short-chained alcohols have been proposed as an alternative working fluid. In this contribution, the working flow from adsorbent (HKUST-1) characterization up to technical application is presented. Beginning with the thorough characterization of the process of direct crystallization on different structures, the results of methanol adsorption measurements are presented. Coatings are evaluated by applying the Dubinin–Astakhov approach to describe adsorption data and to calculate a coefficient of performance (COP). The maximum methanol uptake of the coatings was approximately 0.6 gMeOH/gMOF, leading to a COP of 1.5 at given temperatures. With respect to the cyclic application, the stability of HKUST-1 and methanol has also been investigated.
HPLC Analysis of Stemokerrine and Oxystemokerrine in the Thai Medicinal Plant Stemona kerrii (2012)

A HPLC-UV method was developed and validated for determination of stemokerrine and oxystemokerrine in Stemona kerrii roots. The chromatographic separation was performed on a Hypersil BDS Cl8-column eluted with methanol: 50 mM ammonium acetate solution using a gradient system with a flow rate of 1 mL/min and detection at 300 nm. Stemokerrine and oxystemokerrine showed a linear relationship within the range of 0.5-100 microg/mL. The method was shown to be precise with a RSD <2%. The average percent recovery of stemokerrine was 101.6% and for oxystemokerrine 99.5%. Two samples of S. kerrii were analyzed and the average contents of stemokerrine and oxystemokerrine were 0.2 and 0.05%, w/w, respectively. The present work will provide a useful standardization method for S. kerrii raw materials for further pharmaceutical development.
Thermal fluctuations in superconductor/ferromagnet nanostripes (2015)

Thermal fluctuations in hybrid superconductor/ferromagnetic $\mathrm{NbN}/\mathrm{NiCu}$ bilayers, as well as in pure superconducting NbN, two-dimensional (2D), nanostripes, have been investigated in order to understand the origin of dark counts in superconducting nanostripes when operated as single-photon detectors in the temperature range from $4.2\phantom{\rule{0.28em}{0ex}}\mathrm{to}\phantom{\rule{0.28em}{0ex}}8\phantom{\rule{0.16em}{0ex}}\mathrm{K}$. In 2D superconductors, the dynamics of vortex motion play a significant role in the formation of a transient normal state, leading to dark-count events in current-biased nanostripes. By introducing a weak ferromagnetic overlayer on top of pure NbN, we managed to control the vortex dynamics, which subsequently enabled us to differentiate between several proposed theoretical models. In particular, a $6\phantom{\rule{4.pt}{0ex}}\text{\ensuremath{-}}\phantom{\rule{4.pt}{0ex}}\text{nm}\phantom{\rule{4.pt}{0ex}}\text{\ensuremath{-}}\phantom{\rule{4.pt}{0ex}}\text{thick}$ NiCu film grown on top of $8\phantom{\rule{4.pt}{0ex}}\text{\ensuremath{-}}\phantom{\rule{4.pt}{0ex}}\text{nm}\phantom{\rule{4.pt}{0ex}}\text{\ensuremath{-}}\phantom{\rule{4.pt}{0ex}}\text{thick}$ NbN nanostripes led to an enhanced critical current density in the resulting nanostructure, as well as significantly lowered fluctuation rates, as compared to pure NbN structures, leading to reduced dark counts. The enhancement of pinning in $\mathrm{NbN}/\mathrm{NiCu}$ bilayers provided evidence that thermal excitations of single vortices (vortex hopping) near the edge of a 2D nanostripe were the dominant mechanism of the observed dark-count transients. On the other hand, in pure NbN the leading source of thermal fluctuations was the current-assisted thermal unbinding of vortex-antivortex pairs.
Influence of the mask magnification on imaging in hyper-NA lithography (2007)

Argon fluoride laser (ArF) lithography using immersion technology has the potential to extend the application of optical lithography to 45 nm half-pitch and possibly beyond. By keeping the same 4x magnification factor, the dimensions of the structures on masks are becoming comparable to the exposure wavelength or even smaller. The polarization effect induced by mask features is, however, an issue. The introduction of a larger mask magnification should be strongly considered when poor diffraction efficiencies from subwavelength mask features and the resulting image degradation would be encountered in hyper-NA lithography. The dependence of the diffraction efficiencies on mask pitch and illuminating angle are evaluated. The near-field intensity and phase distributions from the mask are calculated. The imaging performance of 4x and 8x masks for the sub-45 nm node are explored. A rigorous coupled-wave analysis is developed and employed to analyze the optical diffraction from the 3D topographic periodic features.
Computational modeling of arterial tissues: coupling multiscale homogenization strategies and finite element formulation (2019)

Keywords: Non-linear finite-element formulationmultiscale homogenizationarterial micromechanicsfibrous tissue
Hybrid mixed media nonwovens composed of macrofibers and microfibers. Part I: three-layer segmented pie configuration (2013)

Nonwoven fabrics, composed of microdenier fibers, can be easily created by using splittable bicomponents such as segmented pie. Hydroentangling has been shown as a very effective method for mechanically splitting these fibers. Such structures are known to form a densely packed nonwoven fabric with concomitant consequences in low porosity and tear strength. It is not, therefore, uncommon to insert a reinforcing scrim as a “rip-stop” mechanism in the middle of such structures to improve their properties, especially tear resistance. Instead, we propose a hybrid structure where the middle portion consists of solid homocomponent fibers, made from the same polymer as one of the components used in the bicomponent fibers, produced simultaneously during web formation, without causing noticeable changes in the fabrics’ overall texture. We report on the production and properties of fabrics composed entirely of bicomponent segmented pie fibers as well as our hybrid fabrics arranged in a three-layer configuration.
Prevalence of Corynebacterial 16S rRNA Sequences in Patients with Bacterial and “Nonbacterial” Prostatitis (1999)

The etiology of chronic prostatitis syndromes in men is controversial, particularly when positive cultures for established uropathogens are lacking. Although identification of bacteria in prostatic fluid has relied on cultivation and microscopy, most microorganisms in the environment, including some human pathogens, are resistant to cultivation. We report here on an rRNA-based molecular phylogenetic approach to the identification of bacteria in prostate fluid from prostatitis patients. Positive bacterial signals were seen for 65% of patients with chronic prostatitis overall. Seven of 11 patients with bacterial signals but none of 6 patients without bacterial signals were cured with antibiotic-based therapy. Results indicate the occurrence in the prostate fluid of a wide spectrum of bacterial species representing several genera. Most rRNA genes were closely related to those of species belonging to the genera Corynebacterium, Staphylococcus, Peptostreptococcus, Streptococcus, and Escherichia. Unexpectedly, a wide diversity of Corynebacterium species was found in high proportion compared to the proportions of other bacterial species found. A subset of these 16S rRNA sequences represent those of undescribed species on the basis of their positions in phylogenetic trees. These uncharacterized organisms were not detected in control samples, suggesting that the organisms have a role in the disease or are the consequence of the disease. These studies show that microorganisms associated with prostatitis generally occur as complex microbial communities that differ between patients. The results also indicate that microbial communities distinct from those associated with prostatitis may occur at low levels in normal prostatic fluid.
A statistical test suite for random and pseudorandom number generators for cryptographic applications (2010)

The Information Technology Laboratory (ITL) at the National Institute of Standards and Technology (NIST) promotes the U.S. economy and public welfare by providing technical leadership for the nation's measurement and standards infrastructure. ITL develops tests, test methods, reference data, proof of concept implementations, and technical analysis to advance the development and productive use of information technology. ITL's responsibilities include the development of technical, physical, administrative, and management standards and guidelines for the cost-effective security and privacy of sensitive unclassified information in Federal computer systems.