gebhart/patrepeval huggingface dataset:
Determinants of Infection with Schistosomiasis Haematobia Using Logistic Regression (1997)

A population-based stratified random sample of 10,039 inhabitants of rural communities in Minya Governorate, Egypt, were evaluated for risk factors for Schistosoma haematobium infection using multivariate analysis. Data were obtained by personal interview recording demographics, information on exposure to canal water, history of infection, and other risk factors for infection and examining urine samples for S. haematobium ova. Logistic regression analysis was used to adjust for confounders while assessing the role of each risk factor for infection. Using logistic regression allowed detection of several confounders and interactions which influenced other independent variables. Differences in exposure patterns to canal water among age and gender subgroups explained only a small portion of the variation in infection rates, thus favoring the alternative explanation: development of age-acquired immunity. The association of age with reduced prevalence of S. haematobium was the only relationship increasing (odds ratio [OR] = 2.95-4.30) with logistic regression. Male gender was a risk factor for infection but did not increase with logistic regression (OR = 2.33-2.03). The protective effects of education, only noted in schoolage children (OR = 0.59-0.51), were believed to be due to a school-based screening and treatment program.
Fluctuations of a focused beam wave for atmospheric turbulence probing (1969)

This paper demonstrates that a focused beam wave may be effectively used to probe the atmospheric turbulence. Unlike plane and spherical waves, the focused beam has two parameters, i.e., the beam size and the radius of curvature of phase front at the aperture which may be easily varied experimentally. General formulations for the amplitude and phase correlation functions and structure functions of a focused beam wave are given including the effects of wind velocity and time delay. The effects of the beam size and the focal length on the spectral and spatial filter functions and temporal frequency spectrum are examined in detail including the effects of separation, wind velocity, and time delay. Using these functions, procedures are shown to probe the form of the spectral density of the index of refraction, the structure constant, and the wind velocity along the path.
Object Oriented Software Engineering: A (1991)

A text on industrial system development using object- oriented techniques, rather than a book on object-oriented programming. Will be useful to systems developers and those seeking a deeper understanding of object orientation as it relates to the development process.
Metamodeling Driven IP Reuse for System-on-chip Integration and Microprocessor Design (2007)

This dissertation addresses two important problems in reusing intellectual properties (IPs) in the form of reusable design or verification components. The first problem is associated with fast and effective integration of reusable design components into a System-on-chip (SoC), so faster design turn-around time can be achieved, leading to faster time-to-market. The second problem has the same goals of faster product design cycle, but emphasizes on verification model reuse, rather than design component reuse. It specifically addresses reuse of reusable verification IPs to enable a “write once, use many times ” verification strategy. This dissertation is accordingly divided into part I and part II which are related but describe the two problems and our solutions to them. These two related but distinctive problems faced by system design companies have been tackled through a unique approach which hither-to-fore only have been used in the software engineering domain. This approach is called metamodeling, which allows creating customized meta-language to describe the syntax and semantics for a modeling domain. It provides a way to create, transform and analyze domain specific languages, which are themselves described by metamodels, and the transformation and processing of models in such languages are also
Carbonyl Carbon and Nitrogen Chemical Shift Tensors of the Amide Fragment of Acetanilide and N-Methylacetanilide (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbonyl Carbon and Nitrogen Chemical Shift Tensors of the Amide Fragment of Acetanilide and N-MethylacetanilideMichael D. Lumsden, Roderick E. Wasylishen, Klaus Eichele, Michael Schindler, Glenn H. Penner, William P. Power, and Ronald D. CurtisCite this: J. Am. Chem. Soc. 1994, 116, 4, 1403–1413Publication Date (Print):February 1, 1994Publication History Published online1 May 2002Published inissue 1 February 1994https://pubs.acs.org/doi/10.1021/ja00083a028https://doi.org/10.1021/ja00083a028research-articleACS PublicationsRequest reuse permissionsArticle Views580Altmetric-Citations43LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Dighity of Teaching (1975)

(1975). The Dighity of Teaching. Improving College and University Teaching: Vol. 23, Women Professors, pp. 2-2.
Effects of Au nanoparticle addition to hole transfer layer in organic solar cells based on copper naphthalocyanine and fullerene (2014)

Organic solar cells based on copper naphthalocyanine (CuNc) and fullerene (C60) were fabricated, and their photovoltaic properties were investigated. C60 and CuNc were used as n-type and p-type semiconductors, respectively. In addition, the effect of Au nanoparticle addition on a hole transfer layer was investigated, and the power conversion efficiency of the devices was improved after blending the Au nanoparticles into the hole transport layer. Nanostructures of Au nanoparticles were investigated by transmission electron microscopy and X-ray diffraction. Energy levels of molecules were calculated by molecular orbital calculations, and the nanostructure and electronic properties were discussed.
Synthesis and biosynthesis of some naturally occuring oxygen heterocycles (2003)

The first chapter of this thesis describes the stereocontrolled synthesis of the stereoisomers of 5-n-butyltetrahydrofuro-[3,2-b]furan-2(3H)-one and 5-n-hexyltetrahydrofuro-[ 3,2-b]furan-2(3H)-one, which had been identified in the Hagen's gland extracts of some braconid wasps. Jacobsen's Hydrolytic Kinetic Resolution (HKR) was utilised, along with a one pot, palladium catalysed hydroxycyclisation-carbonylation-lactonisation reaction that delivered the bicyclic lactones in an efficient manner. Enantioselective gas chromatography of the synthesized compounds, ensured that reliable values were obtained for the optical rotations. This methodology was then apphed to the synthesis of a tetrahydrofuro- [3,2-b]furan-2(3H)-one system that contained a p-bromobenzyl substituent, with the aim of
 producing a compound suitable for X-ray structural analysis. The second chapter describes the synthesis of stereoisomers of 2,3,8-trimethyl-1,7- dioxaspiro[5.5]undecane, utilising several approaches, including hydroxymercuration-cyclisation of an appropriate dienone; asymmetric dihydroxylation-cyclisation of a dienone; and a completely stereocontrolled, hydrazone based synthesis. The synthesised 2,3,8-trimethyl-1,7-dioxaspiro[5.5]undecane was then appraised as a component of the dorsal abdominal glandular extracts of the native aposematic shield bug, Cantao parentum.The third chapter describes the isolation of bistramide A, a spiroacetal containing marine natural product that holds much promise in the area of cell signaling research. The NMR analysis of bistramide A was suggestive of the relative stereochemistry of the spiroacetal ring system. This stereochemistry was confirmed by the synthesis of a suitable
 sub-fragment and comparisons with the natural sample. The stereochemistry found in bistramide A must also apply to the other members of the bistramide series of marine metabolites. The final chapter of this thesis details studies into the biosynthesis of spiroacetal containing pheromones in two species of Suit fly, Bactrocera cucumis and Bactrocera cacuminata. Stereochemically defined, deuterated precursors were synthesized and administered to the fruit flies in order to elucidate the likely biosynthetic pathway leading to spiroacetal formation. The feeding experiments were performed under an atmosphere containing [18O2]-dioxygen, and the results strongly suggested that a cytochrome P450 was involved. Information was also gained about the stereochemistry of the naturally occurring precursors, and about the possibility of multiple precursor compounds, which could be
 preferentially processed by the fruit flies.
A clinical study of patients with multiple isolated neurofibromas (2001)

Editor—Neurofibromas are benign nerve sheath tumours of a heterogeneous nature consisting of Schwann cells, fibroblastic elements, and embedded axons. Neurofibromas may occur singly in genetically normal people at any point along the peripheral nervous system. Multiple neurofibromas are nearly pathognomonic for neurofibromatosis 1 (NF1). In patients with NF1, neurofibromas may be congenital and plexiform or, more commonly, may be smaller masses that begin to accumulate around the time of puberty. Cutaneous and subcutaneous neurofibromas may cause considerable cosmetic disfigurement, but rarely result in neurological dysfunction. Conversely, deep seated neurofibromas on peripheral nerves and spinal roots frequently lead to neurological disability. Inevitably, adult patients with NF1 have other stigmata of the disorder with the most common being cafe au lait spots, skin fold freckling, and Lisch nodules.1 2 NF1 is an autosomal dominant disorder with full penetrance and a defined genetic aetiology that shows no evidence of locus heterogeneity.3Neurofibromatosis 2 patients are rarely found to have one or more neurofibromas.4 5 

Recently, we have become aware of a small number of patients with multiple pathologically proven neurofibromas, who have no other stigmata of NF1. Here we report the clinical characteristics and pathological findings of these patients, and propose the terminology “multiple isolated neurofibromas” to describe this rare condition.

The criteria for inclusion in the study were multiple, pathologically proven neurofibromas without other defining features of NF1. Careful family histories were obtained in order to document other family members potentially affected, extending to all second degree relatives. Each participant underwent a clinical examination by one or more of the authors (PB, MM, MPS), which included a detailed neurological evaluation and inspection of the skin with a Wood's lamp. For patients who gave a positive family history, medical records from the potentially affected family member and tumour specimens …
Alignments (2007)

Alignments constitute one of the processes commonly used to compare strings. They allow to visualize the resemblance between strings. This chapter deals with several methods that perform the comparison of two strings in this sense. The extension to comparison methods of more than two strings is delicate, leads to algorithms whose execution time is at least exponential, and is not treated here.
Cyclische Sulfoximide, V. 3‐Amino‐1λ4,2,4‐benzothiadiazin‐1‐oxide (1976)

Abstract S‐(2‐Aminophenyl)sulfoximide 1 wurden nach verschiedenen Methoden in die 3‐Amino‐1λ 4 ,2,4‐benzothiadiazin‐1‐oxide 2 , 4 und 6 übergeführt. Umsetzung von 3‐Methylthio‐1λ 4 ,2,4‐benzothiadiazin‐1‐oxiden 8 mit Formylhydrazin lieferte die neuartigen tricyclischen Sulfoximide 9 .
Fairness andPhysical LayerCapture inRandomAccess Networks (2007)

Whilephysical layercapture hasbeenob- served inrealimplementations ofwireless devices which randomlyaccessing sharedchannels, fairratecontrol algorithms basedonaccurate channel modelsdescribing thephenomenon havenotbeendeveloped. Inthis paper, usingourgeneral physical channel model, we formally present thecharacteristics ofthefeasible domainofagen- eralfairness problem andutility fairness underphysical layer capture. We showthattheallocation domainisnot convexandtheprevious optimization schemes cannotbe applied. We further showtheobjective function forutility fairness isconcave onthedomainofchannel access attempt probability. Weclarify thattheoptimal attempt probability ofthenodeinthelogutility fairness isproportional toits interference effect onitsneighbors. Basedonouranalysis, wepropose aratedetermination algorithm toachieve log- utility fairness forrandomaccess networks. Running ina fully distributed manner, ourratecontrol algorithm can reachanassignment close totheoptimum, incontrast oftheprevious algorithms causing nodestarvation in presence ofphysical layer capture. Theaccuracy ofour algorithm isverified through simulations andourresults indicate theaccuracy errorforlogutility fairness isless than5% for97%ofthenodes.
Spatial uniformity of single photon 1-D imaging detectors using superconducting tunnel junctions (2002)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation L. Li, L. Frunzio, C. M. Wilson, K. Segall, D. E. Prober, A. E. Szymkowiak, S. H. Moseley; Spatial uniformity of single photon 1-D imaging detectors using superconducting tunnel junctions. AIP Conf. Proc. 5 February 2002; 605 (1): 145–148. https://doi.org/10.1063/1.1457615 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Subject and Longitudinal Use of Books by Indian Space Technologists (1986)

A 20% stratified sample of books of the Indian Space Research Organisation's (ISRO) Satellite Centre (ISAC) Library were examined to record over 14,000 outside borrowings. The use of these books is analysed with frequency tables to pinpoint unused, least used and highly used books. Studies are made also of the relative use of books in different subject groups, longitudinal use over time, subject use of unused and highly used books and distribution of use over age and year of acquisition of the books. The paper concludes by discussing the extent of use of books at the ISAC library and providing findings concerning collection development and weeding processes.
<title>Simultaneous graphics and multislice raster image display for interactive image-guided surgery</title> (1991)

A surgeon typically uses information from a number of tomographic imaging methods (e.g., CT, MR, PET) during the course of a surgical procedure. These imaging techniques represent three-dimensional information as a set of two-dimensional images. To use this information, the surgeon is required to mentally construct a three-dimensional visualization from the set of two- dimensional images. The formation of the mental image becomes more complicated with the inclusion of multiple imaging modalities and multiple imaging planes. We have developed a technique to enhance the mental three-dimensional visualization process through simultaneous graphics and multislice raster image display. The composite display, capable of displaying up to three raster images along with a patient-specific graphics model, is viewed on a 1280 X 1024 monitor. The raster images, displayed in a 512 X 512 format, may be any combination of imaging methods and imaging planes. The graphics model, determined from the imaging data, may be freely rotated as a depth-cued wireframe or shaded-surface model. Regions-of-interest may be incorporated into the graphics model for additional visual cues. Trajectory information may be obtained by moving a three-dimensional cursor in any raster image space or in the graphics model with instantaneous update of the remaining display area. This design allows the surgeon to interactively obtain orientation and visualization information from the images in the operating room. Because the classic imaging planes are used, the surgeon is not required to deal with a new information format or a loss of resolution.
Comparison of interleukin-2-inducible kinase (ITK) inhibitors and potential for combination therapies for T-cell lymphoma (2018)

Patients with peripheral T-cell lymphomas generally have poor clinical outcomes with conventional chemotherapy. Recent advances have demonstrated that a large subgroup of PTCL are derived from follicular helper (Tfh) T-cells. These cases show a characteristic pattern of gene expression, which includes high-level protein expression of interleukin-2-inducible kinase (ITK). ITK is a member of the TEC family of kinases and normally has essential functions in regulating T-cell receptor signalling and T-cell differentiation. Here we report a side-by-side comparison of four ITK inhibitors. We investigate effects on apoptosis, phosphorylation of signaling molecules, calcium flux and migration. In line with a specific mechanism of action ONO7790500 and BMS509744 did not inhibit MEK1/2 or AKT phosphorylation although other ITK inhibitors, ibrutinib and PF-06465469, did have this effect. Specific ITKi had modest effects on apoptosis alone but there was definite synergy with doxorubicin, pictilisib (PI3Ki) and idelalisib (PI3Kδi). ITKi repressed migration of Jurkat cells caused by CXCL12 and the CXCR4 antagonist, plerixafor enhanced this effect. Overall ITKi may have several mechanisms of action that will be therapeutically useful in PTCL including reduction in survival and perturbation of trafficking.
The Effect of the Illumination Intensity on the Performance of Si Multijunction based Integrated Photoelectrochemical water Splitting Devices (2016)

We present a study of the effect of illumination intensity on the performance of a photovoltaic-biased electrochemical (PV-EC) device for solar hydrogen production based on a triple junction thin film silicon solar cell. The influence of the illumination intensity was studied for the solar cell as well as for an integrated PV-EC device. We show that while the open circuit voltage decreases with a reduction in intensity, the triple junction solar cell still provides a sufficient voltage to drive spontaneous water splitting. Moreover, a slight improvement in the fill factor at lower intensities can relax the requirements to the utilized co-catalysts. As a consequence, the difference in the performance of PV-EC devices featuring very active (Pt/RuO2) and less active (Ni/Co3O4) catalyst materials decreases when the illumination intensity is reduced.
One-step purification of Actinoplanes missouriensis D-xylose isomerase by high-performance immobilized copper-affinity chromatography: functional analysis of surface histidine residues by site-directed mutagenesis (1992)

D-Xylose isomerase (XI) is a heat-stable homotetrameric enzyme used in industry for the production of high-fructose corn syrups by isomerization of D-glucose into D-fructose. To carry out biochemical and structural studies of this enzyme and of its engineered variants, a rapid and convenient method of purification of recombinant Actinoplanes missouriensis XI produced in Escherichia coli has been developed. The availability of surface-accessible histidine residues allows adsorption of XI to immobilized metal-affinity chromatography (IMAC) columns. Knowledge of the physicochemical properties of this enzyme is shown to further warrant rational modifications in the composition of the chromatographic solvents so as to achieve high selectivity in both its interaction with and its elution from a copper-loaded Chelating Sepharose Fast Flow column, an agarose-based matrix derivatized with iminodiacetic acid (IDA) groups. Purification of XI to homogeneity can thus be accomplished in a single chromatographic step starting from crude cell lysates. IDA-Cu(II)-IMAC proves convenient, fast, and reproducible. Moreover, this method is gentle to and hence suitable for mutant enzymes with decreased stability. Its disadvantage is that XI is purified in an inactive form due to inhibition by scavenged Cu2+. This handicap is however easily overcome by means of a polishing step by chromatography on Mono-Q in the presence of the chelator, EDTA. Site-directed mutants have been constructed to assess the role of surface amino acid residues in the IMA recognition event. Substitution of lysine for histidine 41 results in a mutant with near wild-type properties. Yet, this mutation is shown to completely abolish adsorption to IDA-Cu(II). This finding is analyzed in relation to the structural surface properties of the XI enzyme to provide direct evidence for the implication of histidine 41 as the predominant protein ligand to IDA-Cu(II) in IMAC.
In vivo levels of mitochondrial hydrogen peroxide increase with age in mtDNA mutator mice (2014)

In mtDNA mutator mice, mtDNA mutations accumulate leading to a rapidly aging phenotype. However, there is little evidence of oxidative damage to tissues, and when analyzed ex vivo, no change in production of the reactive oxygen species (ROS) superoxide and hydrogen peroxide by mitochondria has been reported, undermining the mitochondrial oxidative damage theory of aging. Paradoxically, interventions that decrease mitochondrial ROS levels in vivo delay onset of aging. To reconcile these findings, we used the mitochondria-targeted mass spectrometry probe MitoB to measure hydrogen peroxide within mitochondria of living mice. Mitochondrial hydrogen peroxide was the same in young mutator and control mice, but as the mutator mice aged, hydrogen peroxide increased. This suggests that the prolonged presence of mtDNA mutations in vivo increases hydrogen peroxide that contributes to an accelerated aging phenotype, perhaps through the activation of pro-apoptotic and pro-inflammatory redox signaling pathways.
88. Stereospecificity in thermal elimination reactions. Part II. The pyrolysis of (—)-menthyl chloride (1952)

D. H. R. Barton, A. J. Head and R. J. Williams, J. Chem. Soc., 1952, 453 DOI: 10.1039/JR9520000453