gebhart/patrepeval huggingface dataset:
Human/robot interaction via the transfer of power and information signals. II. An experimental analysis (2003)

For pt.I see ibid., vol.3, p.1632-40. The author presents concepts involving constrained motion of a class of human-controlled robotic manipulators called extenders. Extenders amplify the strength of the human operator, while utilizing the intelligence of the operator to generate spontaneously the command signal to the system. A single-degree-of-freedom extender has been built for theoretical and experimental verification of the dynamics and control involved in this hardware. The system performance is defined as the amplification of the human power. It is shown that the more amplification is required, the smaller is the stability range of the system.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Targets for producing high purity I-123 (1978)

Tellurium powder in improved targets is bombarded with a cyclotron beam to produce Xe-123. Flowing gas streams carry the Xe-123 through one cold trap which removes Xe-123 that subsequently decays to I-123. During this bombardment energy is deposited in the target material causing its temperature to rise. Some of the tellurium vaporizes and subsequently condenses on surfaces that are cooler than the vaporization temperature. Provision is made for the repeated bombardment of this condensed tellurium.
Pairwise Error Probability of Space-Time Codes in Rician–Nakagami Channels (2004)

In this letter, we investigate the shadowing effect on the performance of space-time codes, using the Rician-Nakagami channel model which has been recently introduced. Specifically, we derive an exact expression for the pairwise error probability (PEP) of space-time trellis codes over the Rician-Nakagami channel, which is in the form of a simple single finite-range integral. We also present numerical results how the PEP expressions for the Rician-Nakagami channel can be related to those for the classical Rician-lognormal channel based on the parameter transformation between these two models.
Using burst recovery concept to obtain global stability and performance of discrete-time adaptive controller for time-varying systems (1994)

In this note, a new technique is proposed for the global stability analysis of adaptive control of time-varying systems. The proposed method is based on the evaluation of possible burstings in the adaptive loop. Its simplicity and effectiveness is demonstrated by analyzing global stability and performance of the discrete-time direct adaptive controller. The developed technique reflects physical phenomena inside the adaptive loop, i.e., possible occurrence of instabilities and burstings. Precise upper bounds on the admissible speed of the parameter variations and on all the signals are established in terms of clearly defined physical quantities.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The signal transducer and activator of transcription 5B gene polymorphism contributes to the cholesterol metabolism in Japanese children with growth hormone deficiency (2011)

These results indicate that STAT5B may therefore play a role in regulating the cholesterol metabolism in children with GHD.
Sequences, gene- and peptide structures of ant inotocins. (2015)

&lt;p&gt;(&lt;b&gt;A&lt;/b&gt;) Sequences of prepro-inotocin/neurophysin proteins from &lt;i&gt;Atta cephalotes&lt;/i&gt;, &lt;i&gt;Camponotus floridanus&lt;/i&gt; and &lt;i&gt;Harpegnathos saltator&lt;/i&gt; were compared by similarity alignment to known inotocin/oxytocin/vasopressin prepro-proteins from &lt;i&gt;Tribolium castaneum&lt;/i&gt; (UniProtKB A3RE83), &lt;i&gt;Nasonia vitripennis&lt;/i&gt; (GenBank XP001606547.1), &lt;i&gt;Homo sapiens&lt;/i&gt; (P01185 and P01178) and &lt;i&gt;Lymnaea stagnalis&lt;/i&gt; (Q00945). The signal peptide cleavage site (identified by similarity) is shown with an arrow. Mature vasopressin/oxytocin/inotocin peptides are indicated in the box, followed by the canonical GRK amidation signal (dotted line above the sequences). The conserved cysteine residues in the neurophysin domain are indicated with asterisks. The sequence alignment was prepared using Boxshade. (&lt;b&gt;B&lt;/b&gt;) Gene structure of novel &lt;i&gt;H.saltator&lt;/i&gt; inotocin and known vasopressin-family prepro-protein genes (GenBank &lt;i&gt;H.sapiens&lt;/i&gt; NC000020.10 and &lt;i&gt;T.castaneum&lt;/i&gt; NC007423.2) was predicted using the GeneWise algorithm. Signal sequences are indicated in light grey, the mature peptide hormone chains (INT, inotocin; AVP, vasopressin; OT, oxytocin) in dark grey, pre-regions in black and the neurophysin domains in white. For the AVP prepro-protein the copeptin region is also marked. Intron sequences (including their base pair length) are indicated with upside-down arrow heads. (&lt;b&gt;C&lt;/b&gt;) Evolution of the vasotocin nonapeptide family (simplified illustration for clarity, see also &lt;a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0032559#pone.0032559-Goodson1" target="_blank"&gt;[42]&lt;/a&gt;, &lt;a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0032559#pone.0032559-Acher1" target="_blank"&gt;[46]&lt;/a&gt;) is indicated by solid arrows. Arginine-vasotocin is the presumed ancestral peptide of oxytocin and vasopressin. Mammalian oxytocin evolved via intermediate forms of isotocin (bony fish) and mesotocin (lung fish, amphibians, reptiles and birds). It is yet to be determined whether invertebrate oxytocin/vasopressin-related peptides in insects or snails (&lt;i&gt;e.g.&lt;/i&gt; conopressins, not shown) have also evolved from ancestral vasotocin (indicated as dashed line) &lt;a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0032559#pone.0032559-Goodson1" target="_blank"&gt;[42]&lt;/a&gt;. The peptide sequences are shown in one-letter amino acid code. The highly conserved cysteine-residues and disulfide bonds are colored in yellow. Residues in the ancestral arginine-vasotocin and those that are identical to vasotocin are colored in dark grey. Residues that have changed during vasopressin evolution are colored in red, residues that have changed during oxytocin evolution are colored in purple and residues that are unique to insect/ant inotocins are colored in green.&lt;/p&gt;
Finding and Eliminating Noise and Interference in a Test Stand for Josephson Digital Chips (2021)

Sources of noise and interference in a test stand for Josephson digital integrated circuits have been identified and eliminated using a novel measurement technique. The digital output of the chip was fed into a spectrum analyzer while the output pattern was 1010. The DC bias was set at the boundary between correct and incorrect operation, a 50% bit error rate. Small AC noise currents on the bias made large changes in the bit error rate. This converted noise currents to amplitude modulation sidebands of the data pattern at half of the logic clock frequency, which was 625 MHz. AC currents were injected at 454 Hz to produce AM sidebands at 625 MHz ± 454 Hz. The sideband power was directly proportional to calibration tone power over the range 50 nA to 10 μA. Noise currents on the DC bias as small as 100 nA were clearly identified at 120 Hz. The largest noise currents in the test setup were found near 40 MHz. Their spectrum of evenly spaced tones indicated that the source was a switching power supply. When an idle relay controller was turned off, the noise tones immediately disappeared from the spectrum analyzer display, confirming the source of interference. This new and easy to use technique exploited bit error rate modulation to up convert AC noise currents from low frequencies to the range 625-675 MHz. The location of the noise currents was unambiguous, since only a 60 Hz noise current on the chip could produce an AM sideband at 625 MHz plus 60 Hz.
Trail: a track-based logging disk architecture for zero-overhead writes (2002)

A novel disk architecture called Trail is proposed to optimize the disk write latency without sacrificing the disk read performance. This architecture features a track-based logging technique, which essentially reduces a disk write latency to the transfer delay. In addition, this disk architecture allows concurrent read/write, and implicit write scheduling without compromising data integrity. Through a synthetic-trace simulation study, we have shown that for transaction processing workloads, the write latency improvement of Trail over conventional disk devices is at least an order of magnitude. Trail's read latency performance is also better in all cases, sometimes the improvement is also over an order of magnitude. In terms of disk bandwidth utilization, the Trail architecture has a close to 100% write bandwidth efficiency and a read bandwidth efficiency at least as good as a conventional disk.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Performance Improvement of Algebraic Multigrid Solver by Vector Sequence Extrapolation (2007)

Algebraic Multigrid Method (AMG) performance im-provement by vector sequence extrapolation is exam-ined. Projective Forward Extrapolation (PFE), Min-imal Polynomial Extrapolation (MPE) and Reduced Rank Extrapolation (RRE) are applied to the AMG resulting in a hybrid approach, vector extrapolated AMG. The impact of vector sequence extrapolation is shown to improve performance of the AMG in number of cycles and execution time, resulting in three new methods: PFE-AMG, MPE-AMG and RRE-AMG. Computational results of the application of vector ex-trapolated AMG to sparse matrices arising from dis-cretization of fluid flow equations are presented show-ing performance improvements compared to the tradi-tional AMG. 1
Nanotopography of Polystyrene/Poly(methyl methacrylate) for the Promotion of Patient Specific Von Willebrand Factor Entrapment and Platelet Adhesion in a Whole Blood Microfluidic Assay (2023)

Platelet function testing is essential for the diagnosis of patients with bleeding disorders. Specifically, there is a need for a whole blood assay that is capable of analysing platelet behaviour in contact with a patient-specific autologous von Willebrand factor (vWF), under physiologically relevant conditions. The creation of surface topography capable of entrapping and uncoiling vWF for the support of subsequent platelet adhesion within the same blood sample offers a potential basis for such an assay. In this study, spin coating of polystyrene/poly (methyl methacrylate) (PS/PMMA) demixed solutions onto glass substrates in air has been used to attain surfaces with well-defined topographical features. The effect of augmenting the PS/PMMA solution with uniform 50 µm PS microspheres that can moderate the demixing process on the resultant surface features has also been investigated. The topographical features created here by spin coating under ambient air pressure conditions, rather than in nitrogen, which previous work reports, produces substrate surfaces with the ability to entrap vWF from flowing blood and facilitate platelet adhesion. The direct optical visualisation of fluorescently-labelled platelets indicates that topography resulting from inclusion of PS microspheres in the PS/PMMA spin coating solution increases the total number of platelets that adhere to the substrate surface over the period of the microfluidic assay. However, a detailed analysis of the adhesion rate, mean translocating velocity, mean translocation distance, and fraction of the stably adhered platelets measured during blood flow under arterial equivalent mechanical shear conditions indicates no significant difference for topographies created with or without inclusion of the PS microspheres.
Adsorption of heavy metal ions from aqueous solutions by porous polyacrylonitrile beads (2002)

Abstract The adsorption of Cu(II), Ni(II), Zn(II), and Pb(II) from aqueous solutions on acrylonitrile copolymer sorbents was studied. We prepared five types of sorbents from polyacrylonitrile by varying its concentration in the initial polymer solution and the composition of the coagulation bath, aiming to achieve a different porous structure. The specific area, pore volume, and pore radius of the sorbents were determined on a porosimeter. The porous structure was studied by scanning electron microscopy. Modification of sorbents with sodium hydroxide and hydroxylamine was carried out to form amidooxyme and carboxylic groups with proven complex‐forming properties toward heavy metal ions. The optimal pH of the sorption of metal ions was found. The adsorption kinetics were investigated. The order of polymer sorbents toward the sorption of Pb(II), Cu(II), Ni(II), and Zn(II) ions, and the order of heavy metal uptake were determined for all types of sorbents. The effectiveness of heavy metal desorption and the coefficient of recovery of sorption ability were determined. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 83: 3036–3044, 2002; DOI 10.1002/app.2334
A Case Report for Acute Myopericarditis After NVX-CoV2373 (Novavax®) COVID-19 Vaccination (2022)

Post-vaccination myocarditis after administration of the NVX-CoV2373 coronavirus disease 2019 (COVID-19) vaccine has been reported in a limited population. We report the first biopsy-proven case of myopericarditis after administration of second dose of NVX-CoV2373 COVID-19 vaccine (Novavax®) in Korea. A 30-year-old man was referred to emergency department with complaints of chest pain and mild febrile sense for two days. He received the second dose vaccine 17 days ago. Acute myopericarditis by the vaccination was diagnosed by cardiac endomyocardial biopsy. He was treated with corticosteroid 1 mg/kg/day for 5 days and tapered for one week. He successfully recovered and was discharged on the 12th day of hospitalization. The present case suggests acute myopericarditis as a vaccination complication by Novavax® in Korea.
Anaplastic Lymphoma Kinase Is Activated through the Pleiotrophin/Receptor Protein Tyrosine Phosphatase (RPTP)β/ζ Signaling Pathway: A Unique Mechanism of Activation of Receptor Protein Tyrosine Kinases. (2006)

Abstract Anaplastic Lymphoma Kinase (ALK) is a receptor-type transmembrane tyrosine kinase (RTK) of the insulin receptor superfamily that structurally is most closely related to leukocyte tyrosine kinase. It was first discovered as a chimeric protein (NPM-ALK) of nucleophosmin and the C-terminal (kinase) domain of ALK in anaplastic large cell lymphomas (ALCL). NPM-ALK is constitutively active and generates the oncogenic signals that are the pathogenic mechanisms of these highly malignant cancers. The full-length ALK also is believed to have an important role in the pathogenesis of other human malignancies, since its expression is found in rhabdomyosarcomas, neuroblastomas, neuroectodermal tumors, glioblastomas, breast carcinomas, and melanomas. Recently it was proposed that pleiotrophin (PTN the protein, Ptn the gene) is the ligand that stimulates ALK to transduce signals to activate downstream targets. However, this proposal contrasted with earlier studies that demonstrated Receptor Protein Tyrosine Phosphatase (RPTP)β/ζ is the functional receptor for PTN. PTN was shown to inactivate RPTPβ/ζ and thereby permit the activity of different tyrosine kinases to increase tyrosine phosphorylation of the substrates of RPTPβ/ζ at the sites that are dephosphorylated by RPTPβ/ζ in cells not stimulated by PTN. Subsequent studies identified β-catenin, β-adducin, Fyn, GIT1/Cat-1, P190RhoGAP, and histone deacetylase 2 (HDAC-2) as downstream targets of the PTN/RPTPβ/ζ signaling pathway and demonstrated that their levels of tyrosine phosphorylation increase in PTN-stimulated cells. This diversity of PTN-regulated targets is one basis for the pleiotrophic activities of PTN. We now demonstrate that tyrosine phosphorylation of ALK is increased in PTN-stimulated cells through the PTN/RPTPβ/ζ signaling pathway. It is furthermore shown that ALK is activated in PTN-stimulated cells when it is expressed in cells without its extracellular domain, that β-catenin is a substrate of ALK, that the tyrosine phosphorylation site in β-catenin phosphorylated by ALK is the same site dephosphorylated by RPTPβ/ζ, and that PTN-stimulated tyrosine phosphorylation of β-catenin requires expression of ALK. The data suggest a unique mechanism to activate ALK; the data support a mechanism in which β-catenin is phosphorylated in tyrosine through the coordinated inactivation of RPTPβ/ζ, the activation of the tyrosine kinase activity of ALK, and the phosphorylation of β-catenin by ALK at the same site regulated by RPTPβ/ζ in PTN-stimulated cells. Since PTN often is inappropriately expressed in the same malignancies that express ALK, the data suggest a mechanism through which ALK signaling may contribute to those malignancies that express full length ALK through the activity of PTN to signal constitutively the same pathways as NPM-ALK in ALCL.
T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes (2021)

Unlike chimeric antigen receptors, T-cell receptors (TCRs) can recognize intracellular targets presented on human leukocyte antigen (HLA) molecules. Here we demonstrate that T cells expressing TCRs specific for peptides from the intracellular lymphoid-specific enzyme terminal deoxynucleotidyl transferase (TdT), presented in the context of HLA-A*02:01, specifically eliminate primary acute lymphoblastic leukemia (ALL) cells of T- and B-cell origin in vitro and in three mouse models of disseminated B-ALL. By contrast, the treatment spares normal peripheral T- and B-cell repertoires and normal myeloid cells in vitro, and in vivo in humanized mice. TdT is an attractive cancer target as it is highly and homogeneously expressed in 80-94% of B- and T-ALLs, but only transiently expressed during normal lymphoid differentiation, limiting on-target toxicity of TdT-specific T cells. TCR-modified T cells targeting TdT may be a promising immunotherapy for B-ALL and T-ALL that preserves normal lymphocytes.
A Multi-Cell-to-Multi-Cell Equalizer for Series-Connected Batteries Based on Flyback Conversion (2019)

This paper proposes a multi-cell-to-multi-cell (MC2MC) equalizer for series-connected lithium-ion battery strings based on flyback conversion and its control method. An onboard 12 V lead-acid battery is used as the energy transfer station to reduce a half of switches. Different from the traditional equalizer, this equalizer can directly transfer energy from the higher-voltage cells (i.e., the optimal discharging combination) to the lead-acid battery and deliver energy from the lead-acid battery to the lower-voltage cells(i.e., the optimal charging combination), which greatly improves the equalization speed. The pulse-width modulation (PWM) duty cycle can be adjusted according to the voltage of the optimal charging or discharging combination during equalization, so that the balancing current and speed will not decrease with the decrease of the voltage difference among cells. Moreover, the demagnetization for the transformer can be realized in the discontinuous mode of the bidirectional flyback converter, thereby improving the stability of the equalization system. The simulation results show that with the proposed equalizer, the cell voltage difference can be decreased from 540 mV to 2 mV within 1500s, leading to a fast balancing speed.
Carbon nanotubes towards medicinal biochips (2009)

This overview focuses on the recent advances in carbon nanotube (CNT)-based biochips and tries to clarify their potential for modern molecular medicine.
Electrical properties of starch-PVA biodegradable polymer blend (2015)

Solid polymer electrolyte films were prepared by adding different contents of potassium chloride (KCl) in a polymer matrix composed of two versatile biodegradable polymers: starch and polyvinyl alcohol (PVA), using the solution cast method. The complexation of the added salt (KCl) with the polymer matrix was confirmed from an x-ray diffraction study (XRD). The evolution of a smooth and uniform morphology with the increasing content of KCl was confirmed from scanning electron microscopy (SEM). The transference number measurement established ions as the dominant charge carriers in the system. The maximum ionic conductivity ∼5.44 × 10−5 S cm−1 at ambient conditions was obtained for the film with 1.5 wt% of KCl using complex impedance spectroscopy. The ionic conductivity and dielectric constant increased with the salt content, thus affirming the amplification in the number of charge carriers. The noteworthy aspect of the investigation is the observation of appreciable ionic conductivity at a relatively low salt content. Low values of activation energy obtained from temperature-dependent ionic conductivity could be favorable from the point of view of the application. Electric modulus studies confirmed the absence of electrode polarization effects in the polymer electrolyte films. The scaling of the electric modulus shows a distribution of relaxation times in the polymer electrolyte films. The study unveils the efficiency of the starch-PVA blend, with glycerol and citric acid as additives, as a hopeful material for preparing biodegradable solid polymer electrolyte films.
Detecting COVID-19 and Community Acquired Pneumonia using Chest CT scan\n images with Deep Learning (2021)

We propose a two-stage Convolutional Neural Network (CNN) based\nclassification framework for detecting COVID-19 and Community-Acquired\nPneumonia (CAP) using the chest Computed Tomography (CT) scan images. In the\nfirst stage, an infection - COVID-19 or CAP, is detected using a pre-trained\nDenseNet architecture. Then, in the second stage, a fine-grained three-way\nclassification is done using EfficientNet architecture. The proposed\nCOVID+CAP-CNN framework achieved a slice-level classification accuracy of over\n94% at identifying COVID-19 and CAP. Further, the proposed framework has the\npotential to be an initial screening tool for differential diagnosis of\nCOVID-19 and CAP, achieving a validation accuracy of over 89.3% at the finer\nthree-way COVID-19, CAP, and healthy classification. Within the IEEE ICASSP\n2021 Signal Processing Grand Challenge (SPGC) on COVID-19 Diagnosis, our\nproposed two-stage classification framework achieved an overall accuracy of 90%\nand sensitivity of .857, .9, and .942 at distinguishing COVID-19, CAP, and\nnormal individuals respectively, to rank first in the evaluation. Code and\nmodel weights are available at\nhttps://github.com/shubhamchaudhary2015/ct_covid19_cap_cnn\n
Uncommon Endocytic and Trafficking Pathway of the Natural Killer Cell CD94/NKG2A Inhibitory Receptor (2008)

The CD94/NKG2A inhibitory receptor, expressed by natural killer and T cells, is constantly exposed to its HLA‐E ligand expressed by surrounding cells. Ligand exposure often induces receptor downregulation. For CD94/NKG2A, this could potentiate activation receptor(s) induced responses to normal bystander cells. We investigated CD94/NKG2A endocytosis and found that it occurs by an amiloride‐sensitive, Rac1‐dependent macropinocytic‐ like process; however, it does not require clathrin, dynamin, ADP ribosylation factor‐6, phosphoinositide‐3 kinase or the actin cytoskeleton. Once endocytosed, CD94/NKG2A traffics to early endosomal antigen 1 + , Rab5 + early endosomes. It does appear in Rab4 + early/sorting endosome, but, in the time period examined, fails to reach Rab11 + recycling or Rab7 + late endosomes or lysosome‐associated membrane protein‐1 + lysosomes. These results indicate that CD94/NKG2A utilizes a previously undescribed endocytic mechanism coupled with an abbreviated trafficking pattern, perhaps to insure surface expression.