gebhart/patrepeval huggingface dataset:
Single-step synthesis and magnetic separation of graphene and carbon nanotubes in arc discharge plasmas (2010)

The unique properties of graphene and carbon nanotubes made them the most promising nanomaterials attracting enormous attention, due to the prospects for applications in various nanodevices, from nanoelectronics to sensors and energy conversion devices. Here we report on a novel deterministic, single-step approach to simultaneous production and magnetic separation of graphene flakes and carbon nanotubes in an arc discharge by splitting the high-temperature growth and low-temperature separation zones using a non-uniform magnetic field and tailor-designed catalyst alloy, and depositing nanotubes and graphene in different areas. Our results are very relevant to the development of commercially-viable, single-step production of bulk amounts of high-quality graphene.
Optimization of in vitro expansion of human multipotent mesenchymal stromal cells for cell‐therapy approaches: Further insights in the search for a fetal calf serum substitute (2006)

There is great interest in mesenchymal stromal cells (MSCs) for cell-therapy and tissue engineering approaches. MSCs are currently expanded in vitro in the presence of fetal calf serum (FCS); however, FCS raises concerns when used in clinical grade preparations. The aim of this study was to evaluate whether MSCs expanded in medium supplemented with platelet-lysate (PL), already shown to promote MSC growth, are endowed with biological properties appropriate for cell-therapy approaches. We confirm previously published data showing that MSCs expanded in either FCS or PL display comparable morphology, phenotype, and differentiation capacity, while PL-MSCs were superior in terms of clonogenic efficiency and proliferative capacity. We further extended these data by investigating the immune-regulatory effect of MSCs on the alloantigen-specific immune response in mixed lymphocyte culture (MLC). We found that MSCs-PL are comparable to MSCs-FCS in their capacity to: (i) decrease alloantigen-induced cytotoxic activity; (ii) favor differentiation of CD4+ T-cell subsets expressing a Treg phenotype; (iii) increase early secretion of IL-10 in MLC supernatant, as well as induce a striking augmentation of IL-6 production. As compared with MSCs-PL, MSCs-FCS were more efficient in suppressing alloantigen-induced lymphocyte subset proliferation and reducing early IFNgamma-secretion. Resistance to spontaneous transformation into tumor cells of expanded MSCs was demonstrated by molecular karyotyping and maintenance of normal morphology/phenotype after prolonged in vitro culture. Our data support the immunological functional plasticity of MSCs and suggest that MSCs-PL can be used as an alternative to MSCs-FCS, although these latter cells might be more suitable for preventing/treating alloreactivity-related immune complications.
Evidence for functional ryanodine receptors in Schistosoma mansoni and their putative role in the control of calcium homeostasis (1998)

The main musculature present in adult maleSchistosoma mansoni is mainly of the smoothmuscle type (MH Silk & IM Spence 1969 S Afr JMed Sci 34: 11-20). As we have previously dem-onstrated, the contraction of S. mansoni presents atonic component, dependent on extraworm cal-cium, and a phasic one, dependent on intracellu-lar/intraworm calcium (S da Silva & F Noel 1995Parasitol Res 81: 543-548). Since intracellularcalcium channels sensitive to the alkaloidryanodine and therefore known as ryanodine re-ceptors (RyR) (R Coronado et al. 1994 Am JPhysiol 266: C1485-C1504) have been demon-strated in a variety of mammalian as well as non-mammalian (chicken, frog) and non-vertebratecells (Caenorhabditis elegans , lobster and droso-phila) (G Meissner 1994 Annu Rev Physiol 56:485-508), the main objective of this work was toinvestigate the presence of RyR in S. mansoni, aswell as their subcellular distribution profile, phar-macological modulation and their putative involve-ment in S. mansoni contractility.About 2,000 worms were homogenized in aDounce homogenizer at 4
Studies on Reactive Intermediates. Part V. Reaction of Ketene Dimer with Benzimidazole (1986)

Reaction of ketene d m e r wlth benzmidazole in neat cond~tion at room temperature, gave rlse to 1-10-(N-acetoacetyl--
Pre-Employment Screening of Police Officers (2015)

The Handbook of Police Psychology represents the contributions of over&nbsp;thirty police psychologists, all experts in their field, on the core subject matters of police psychology. Police psychology is broadly defined as the application of psychological principles and methods to law enforcement. This growing area includes topics such as screening and hiring of police officers; conducting screening for special squads (e.g., SWAT); fitness-for-duty evaluations; investigations, hostage negotiations; training and consultation, and stress counseling, among others. The book examines the beginnings of police psychology and early influences on the profession such as experimental&nbsp;investigations of psychological testing on police attitude and performance. Influential figures in the field of police psychology are discussed, including the nation’s first full-time police psychologist who served on the Los Angeles Police Department, and the first full-time police officer to earn a doctorate in psychology while still in uniform with the New York Police Department.
No Administration Protocol (NAP) for IPv6 router auto-configuration (2005)

International audience
Selective Bisubstrate Inhibitors with Sub‐nanomolar Affinity for Protein Kinase Pim‐1 (2013)

Potent and selective: The unique nature of the ATP binding pocket structure of Pim family protein kinases (PKs) was used for the development of bisubstrate inhibitors and a fluorescent probe with sub-nanomolar affinity. Conjugates of arginine-rich peptides with two ATP mimetic scaffolds were synthesized and tested as inhibitors of Pim-1. Against a panel of 124 protein kinases, a novel ARC-PIM conjugate selectively inhibited PKs of the Pim family.
Mutator tRNAs are encoded by the Escherichia coli mutator genes mutA and mutC: a novel pathway for mutagenesis. (1996)

We have previously described the mutator alleles mutA and mutC, which map at 95 minutes and 42 minutes, respectively, on the Escherichia coli genetic map and which stimulate transversions; the A.T-->T.A and G.C-->T.A substitutions are the most prominent. In this study we show that both mutA and mutC result from changes in the anticodon in one of four copies of the same glycine tRNA, at either the glyV or the glyW locus. This change results in a tRNA that inserts glycine at aspartic acid codons. In view of previous studies of missense suppressor tRNAs, the mistranslation of aspartic acid codons is assumed to occur at approximately 1-2%. We postulate that the mutator tRNA effect is exerted by generating a mutator polymerase and suggest that the epsilon subunit of DNA polymerase, which provides a proofreading function, is the most likely target. The implications of these findings for the contribution of mistranslation to observed spontaneous mutation rates in wild-type strains, as well as other cellular phenomena such as aging, are discussed.
Orthogonal Patterning of Multiple Biomolecules Using an Organic Fluorinated Resist and Imprint Lithography (2013)

The ability to spatially deposit multiple biomolecules onto a single surface with high-resolution while retaining biomolecule stability and integrity is critical to the development of micro- and nanoscale biodevices. While conventional lithographic patterning methods are attractive for this application, they typically require the use of UV exposure and/or harsh solvents and imaging materials, which may be damaging to fragile biomolecules. Here, we report the development of a new patterning process based on a fluorinated patterning material that is soluble in hydrofluoroether solvents, which we show to be benign to biomolecules, including proteins and DNA. We demonstrate the implementation of these materials into an orthogonal processing system for patterning multibiomolecule arrays by imprint lithography at room temperature. We further showcase this method's capacity for fabricating patterns of receptor-specific ligands for fundamental cell studies.
De Novo Synthesis of 1,4-Dihydropyridines and Pyridines (2012)

An efficient and general method for the synthesis of 1,4-dihydropyridines and pyridines based on a lithiation/isomerization/intramolecular carbolithiation sequence is reported. This procedure provides an efficient, divergent, and straightforward entry to a wide range of polysubstituted dihydropyridines and pyridines starting from readily available N-allyl-ynamides.
Identification of tRNA-Derived Fragments Expression Profile in Breast Cancer Tissues (2019)

Background: In recent years, tRFs(transfer RNA-Derived Fragments) and transfer RNADerived Stress-induced RNAs (or tRNA halves) have been shown to have vital roles in cancer biology. We aimed to reveal the expression profile of tRNA-derived fragments in breast cancer tissues in the study, and to explore their potential as biomarkers of breast cancer. Methods: We characterized the tRNA-derived fragments expression profile from 6 paired clinical breast cancer tissues and adjacent normal samples. Then we selected 6 significantly expressed tRNAderived fragments and screened the genes for validation by using Quantitative Real-time PCR. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes biological pathway were finally analyzed. Results: We found 30 differentially expressed tRNA-derived fragments across our dataset, out of which 17 were up-regulated, and 13 were down-regulated. Compared with 16 clinical breast cancer tissues and adjacent normal tissues by qPCR, the results demonstrated that tRF-32-Q99P9P9NH57SJ (FC = -2.6476, p = 0.0189), tRF-17-79MP9PP (FC = -4.8984, p = 0.0276) and tRF-32- XSXMSL73VL4YK (FC = 6.5781, p = 0.0226) were significantly expressed in breast cancer tissues (p &lt; 0.001). tRF-32-XSXMSL73VL4YK was significantly up-regulated, and tRF-32- Q99P9P9NH57SJ and tRF-17-79MP9PP were significantly down-regulated in which the expression patterns were similar to the sequencing results. The top ten significant results of GO and KEGG pathways enrichment analysis were presented. Conclusion: Our studies have demonstrated that there were significantly expressed tRNA-derived fragments in breast cancer tissues. They are hopefully to become biomarkers and would be valuable researches in this area.
Solid-phase microextraction for the analysis of biological samples (2000)

Solid-phase microextraction (SPME) has been introduced for the extraction of organic compounds from environmental samples. This relatively new extraction technique has now also gained a lot of interest in a broad field of analysis including food, biological and pharmaceutical samples. SPME has a number of advantages such as simplicity, low cost, compatibility with analytical systems, automation and the solvent-free extraction. The last few years, SPME has been combined with liquid chromatography and capillary electrophoresis, besides the generally used coupling to gas chromatography, and has been applied to various biological samples such as, e.g., urine, plasma and hair. The objective of the present paper is a survey of the application of SPME for the analysis of biological samples. Papers about the analysis of biologically active compounds are categorised and reviewed. The impact of SPME on various analytical fields (toxicological, forensic, clinical, biochemical, pharmaceutical, and natural products) is illustrated. The main features of SPME and its modes are briefly described and important aspects about its application for the determination of pharmaceuticals, drugs of abuse and compounds of clinical and toxicological interest are discussed. SPME is compared with other sample pretreatment techniques. The potential of SPME and its main advantages are demonstrated. Special attention is paid to new trends in applications of SPME in bioanalysis. (C) 2000 Elsevier Science B.V. All rights reserved.
Evidence for a Correlation between Trophoblast Invasiveness and STAT3 Activity (2003)

These results suggest a connection between STAT3 activity and trophoblast invasiveness.
ChemInform Abstract: 3H‐INDOLE 4. MITT. PHOTO‐ UND PEROXID‐INDUZIERTE OX. VON 2‐AETHYL‐3H‐INDOLEN MIT SAUERSTOFF (1970)

Abstract Die Indole (I) werden in Cyclohexan beim Behandeln mit einem Sauerstoffstrom erst nach einigen Tagen vollständig zu den 2‐Acetyl‐Derivaten (II) oxidiert.
An electronic ballast for fluorescent lamps with no series passive elements (2002)

This exploratory study examined the possibility of driving a fluorescent lamp at high frequency with no serially connected passive elements. The proposed driver is a full bridge stage controlled by the phase shifted PWM scheme. Current feedback was used to stabilize the average of the rectified lamp current to a set value. The experimental results of this research confirm the conjecture that an all-electronic fluorescent driver is feasible. Lamp V-I characteristics and lamp resistances were found to be comparable to those measured when the lamp is driven by a conventional HF electronic ballast. The measured light output of a lamp driven by proposed ballast was found to be slightly higher than the light output of same lamp when driven by a conventional HF ballast for the same input power. The paper covers the issue of feedback consideration for ensuring dynamic stability.
Age‐related alterations in erythroid and granulopoietic progenitors in Diamond‐Blackfan anaemia (1994)

Mechanisms involved in the erythroid failure characterizing Diamond-Blackfan anaemia (DBA) remain unidentified. The general consensus is that the defect is intrinsic to the marrow erythroid progenitor, but the target progenitor cell has not been precisely identified, and in vitro studies have revealed considerable heterogeneity between patients. In order to understand better the meaning of such a biological heterogeneity, we examined the in vitro response of erythroid progenitors CFU-E (colony-forming unit-erythroid) and BFU-E (burst-forming unit-erythroid) to erythropoietin (Epo), interleukin-3 (IL-3) and stem cell factor (SCF) in a large series of 24 patients from 1 month to over 20 years of age. Results of colony assays revealed a striking correlation between the age of the patient and the extent of the abnormalities detected in vitro. Therefore, despite profound anaemia, 80% (7/10) of the patients studied within 1 year of diagnosis had normal numbers of both CFU-E and BFU-E which exhibited a normal response to cytokines. In contrast, 12/14 patients followed up for more than 3 years had decreased numbers of erythroid progenitors, in seven cases associated with decreased colony-forming unit granulocyte-macrophage (CFU-GM). The number of CFU-E and BFU-E was not normalized even by the addition of high concentrations of combined Epo, IL-3 and SCF.(ABSTRACT TRUNCATED AT 250 WORDS)
An Analysis of Adaptive Retransmission Arrays in a Fading Environment (1970)

We analyze in this paper the performance of adaptive retransmission for improving two-way communication between antenna arrays in a randomly fading environment. For a stationary environment, S. P. Morgan has shown that complex conjugate retransmission reaches a stable state and maximizes the signal-to-noise ratio of a maximal ratio diversity reception system. We show that a simpler system using phase conjugate retransmission will also stabilize and maximize the signal-to-noise ratio of an equal gain diversity reception system. Where the fading is slow in comparison to the system settling-down time, both systems provide a significant improvement in transmission. Subject to Rayleigh fading, we have obtained the average signal strength and its cumulative probability distribution for various combinations of numbers of antennas in the two arrays for each of the above mentioned systems. This information is useful in choosing an optimal division of diversity branches for the two antenna arrays. It is further observed that although the phase conjugate retransmission system is much simpler to implement, its performance is only slightly inferior to the corresponding complex conjugate system.
Focus Topic 2 – Service Control (2005)

This chapter contains sections titled: Introduction Main concepts Business setting Service information Service control procedures Key findings
On the security of two-way quantum key distribution (2018)

An author (arXiv:1709.09262 [quant-ph] (2017), Nanoscale Research Letters (2017) 12:552) has recently questioned the security of two-way quantum key distribution schemes by referring to attack strategies which leave no errors in the (raw) key shared by the legitimate parties. We argue that the article is based on a flawed understanding of the actual workings of a two-way protocol, thus the erroneous conclusions drawn thereof.
Effect of Significant Weight Change on Inappropriate Implantable Cardioverter‐Defibrillator Therapy (2016)

In mild HF patients receiving CRT-D, significant weight loss at 1 year is associated with increased risk of subsequent inappropriate ICD therapy, including risk related to SVAs.
A REVIEW ON ARTERY WALL SEGMENTATION TECHNIQUES AND INTIMA-MEDIA THICKNESS MEASUREMENT FOR CAROTID ULTRASOUND IMAGES (2011)

Stroke and heart attack, which could be led by a kind of cerebrovascular and cardiovascular disease named as atherosclerosis, would seriously cause human morbidity and mortality. It is important for the early stage diagnosis and monitoring medical intervention of the atherosclerosis. Carotid stenosis is a classical atherosclerotic lesion with vessel wall narrowing down and accumulating plaques burden. The carotid artery of intima-media thickness (IMT) is a key indicator to the disease. With the development of computer assisted diagnosis technology, the imaging techniques, segmentation algorithms, measurement methods, and evaluation tools have made considerable progress. Ultrasound imaging, being real-time, economic, reliable, and safe, now seems to become a standard in vascular assessment methodology especially for the measurement of IMT. This review firstly attempts to discuss the clinical relevance of measurements in clinical practice at first, and then followed by the challenges that one has to face when approaching the segmentation of ultrasound images. Secondly, the commonly used methods for the IMT segmentation and measurement are presented. Thirdly, discussion and evaluation of different segmentation techniques are performed. An overview of summary and future perspectives is given finally.
The Preparation and Clinical Use of Compound Indigo Naturalis Powder (2005)

Aim:to detect the treatment effect of compound Indigo Naturalis powder to oral ulcer.Method:to introduce the prescription, preparation and quality controlling of the compound Indigo Naturalis powder.Result:the effective rate of compound Indigo Naturalis powder to treat oral ulcer is 98%.Conclusion:the preparation has good clinical effect and no adverse effect found, and worth of recommendations to clinical use.
Hotterdam: Urban heat in Rotterdam and health effects (2015)

Heat waves will occur in Rotterdam with greater frequency in the future. Those affected most will be the elderly – a group that is growing in size. In the light of the Paris heat wave of August 2003 and the one in Rotterdam in July 2006, mortality rates among the elderly in particular are likely to rise in the summer. The aim of the Hotterdam research project was to gain a better understanding of urban heat. Heat was measured and the surface energy balance modelled from that perspective. Social and physical features of the city were identified in detail with the help of satellite images, GIS and 3D models. The links between urban heat/surface energy balance and the social/physical features of Rotterdam were determined on the basis of multivariable regression analysis. The decisive features of the heat problem were then clustered and illustrated on a social and a physical heat map. The research project produced two heat maps, an atlas of underlying data.
A New Clinical Technique for Demonstrating Changes in Eye Acceleration During Horizontal Saccades in Patients with Partial Internuclear Ophthalmoplegias (1998)

The eyelid-mounted accelerometer can pick up the acceleration waveform of the eye during horizontal eye movements. The acceleration profile comprises high-amplitude pulsatile activity in the saccade and changes in the level of background ocular microtremor related to eye position. Adducting saccades of 20 degrees were recorded in eight patients with partial internuclear ophthalmoplegias caused by multiple sclerosis and in eight age-matched healthy subjects. The initial pulse of acceleration activity was reduced by 85% in the patients. In the worst-affected cases, adducting saccades were associated only with an increase in the level of background ocular microtremor in the acceleration trace. The results confirm the hypothesis that an internuclear ophthalmoplegia is due to the loss of the pulse signal to ocular motor neurons, with preservation of the step signal in an adducting saccade.
Results with the superconducting electron cyclotron resonance ion source VENUS (invited) (2004)

During the last year, the VENUS electron cyclotron resonance (ECR) ion source was commissioned at 18 GHz and preparations for 28 GHz operation, which is set to begin early in 2004, are now underway. The goal of the VENUS ECR ion source project as the RIA research and development injector is the production of 240 eμA of U30+, a high current medium charge state beam. On the other hand, as an injector ion source for the 88-Inch Cyclotron the design objective is the production of 5 eμA of U48+, a low current, very high charge state beam. During the commissioning phase with 18 GHz, tests with various gases and recently metals have been performed with up to 2000 W rf power and the performance is very promising. For example, 1100 eμA of O6+, 180 eμA of Ar12+, 150 eμA of Xe20+, and 100 eμA of Bi24+ were produced in the early commissioning phase, ranking VENUS among the currently highest performance 18 GHz ECR ion sources. The emittance of the beams produced at 18 GHz was measured with a two axis emittance scanner. In FY04 a 10 kW, 28 GHz gyrotron system will be added, which will enable VENUS to reach full performance. The performance of the VENUS ion source, low energy beam transport and its closed loop cryogenic system are described in the article. Recently, a high temperature axial oven has been installed in the source and the first results on metal beams such as bismuth are given. The design of the 28 GHz, 10 kW gyrotron system will also be described.
A new phase in nonvolatile memory? (2005)

This paper describes recent advances in techniques to develop phase-change memories. These include a new way to facilitate low-voltage phase changes with the use of a tiny strip of amorphous semiconductor compound of germanium, antimony, and tellurium on a layer of silicon dioxide, which is connected to lateral contacts connected to current sources. This configuration allows better control of heat dissipation and use of smaller voltages to change phase. Another development is a device made with a phase-change material based on antimony-tellurium material doped with one or more of the elements of germanium, indium, silver or gallium. This doped material changes phase significantly faster than the germanium-antimony-tellurium compounds in other experiments. Efforts are also underway to create arrays containing memory cells.