gebhart/patrepeval huggingface dataset:
216 Genomic regions and pathways associated with resistance to gastrointestinal parasites in tropical sheep breed (2017)

The aim of this study was to estimate variance components and to identify genomic regions and pathways associated with resistance to gastrointestinal parasites, particularly Haemonchus contortus, in Santa Inês sheep, a Brazilian breed adapted to tropical climate. The degree of anemia assessed by the FAMACHA card (FAM) and the egg counts per gram of feces (EPG) were evaluated to verify the resistance to gastrointestinal parasites. A total of 576 animals were genotyped using 12,785 SNPs of the Ovine SNP12k BeadChip (Illumina, Inc.). The variance components were estimated using a single trait model by single step genomic BLUP (ssGBLUP) procedure. The overall LD mean between marker pairs measured by r2 was 0.23. Heritability estimates were low for EPG (0.11) and high for FAM (0.35). A total of 22 and 21 important windows for EPG and FAM traits were identified. The results of the enriched genes and functional grouping analyses showed that genes associated with FAM and OPG are involved in functions related to the body's immune and defense response. The CCL28 gene located in OAR16 identified both for EPG and FAM acts as a chemotactic for CD4 and CD8 inactive T cells. The metabolic pathway involved in the CCL28 gene and in other genes associated with EPG and FAM, which are related to immunoglobulin synthesis in the intestine. The high heritability observed for FAM suggests that good genetic progress should be possible in selective breeding programs for Santa Inês sheep besides the fact that the FAM is the most precise method to identify an infection by Haemonchus when compared to EPG. This study reported for the first time estimates of linkage disequilibrium between markers and genetic parameters for traits related to gastrointestinal parasite resistance in the Santa Inês sheep breed.
High-speed binary optically addressed spatial light modulator (1989)

We describe the structure and operating characteristics of a high-speed optically addressed spatial light modulator (OASLM) with a hydrogenated amorphous silicon (a-Si:H) photosensor and a ferroelectric liquid-crystal modulator. The photosensor is a p-i-n photodiode, which switches the liquid crystal into one of two stable states. Under a write-light intensity of 6 mW/cm2, the OASLM exhibits a response time of 155 μs, a contrast ratio of 20:1, and a resolution of 40 lp/mm. The writing sensitivity per pixel is 0.1 pJ.
Internet Engineering Task Force (IETF) (2011)

This document describes an RTP payload format for the ReducedComplexity Decoding Operation (RCDO) for H.264 Baseline profile bitstreams, as specified in ITU-T Recommendation H.241. RCDO reduces the decoding cost and resource consumption of the video processing. The RCDO RTP payload format is based on the H.264 RTP payload format.
Online generative model personalization for hand tracking (2017)

We present a new algorithm for real-time hand tracking on commodity depth-sensing devices. Our method does not require a user-specific calibration session, but rather learns the geometry as the user performs live in front of the camera, thus enabling seamless virtual interaction at the consumer level. The key novelty in our approach is an online optimization algorithm that jointly estimates pose and shape in each frame, and determines the uncertainty in such estimates. This knowledge allows the algorithm to integrate per-frame estimates over time, and build a personalized geometric model of the captured user. Our approach can easily be integrated in state-of-the-art continuous generative motion tracking software. We provide a detailed evaluation that shows how our approach achieves accurate motion tracking for real-time applications, while significantly simplifying the workflow of accurate hand performance capture. We also provide quantitative evaluation datasets at http://gfx.uvic.ca/datasets/handy
The Effect of Artificially Extended Photoperiod during Lactation on Maternal Performance of the Sow (1982)

A 20-stall farrowing facility was partitioned into two separate rooms of 10 stalls each so that photoperiod could be controlled. In addition, temperature and air movement were equalized in the two rooms. The two light regimens utilized were 8 h light: 16 h dark, and 16 h light:8 h dark. A total of 26 sows in two replicates were used. Females were moved into the facility on d 103 ±2 of pregnancy, litters were equalized at birth and weaning was at 28 d of age. Traits evaluated included litter size at birth and weaning, 21-d pig and litter weights, milk yield on d 15, survival rate and number of days from weaning to estrus for the sow. The number of pigs born alive was similar across treatments. However, after equalization of litter size, differences in the number weaned/ litter were significant (P<.05) as sows exposed to 16 h of light weaned approximately one pig more per litter. The survival rate within each litter from birth (after equalization) to 21 d of age was greater (P<.05) for sows exposed to 16 h light (91.2%) than for those from sows exposed to 8 h light (81.5%). Milk yield at d 15 was measured for 21 of the sows. The sows exposed to 16 h light produced significantly more milk (P<.05) than sows exposed to 8 h light. The time from weaning to first estrus was similar for each treatment group.
Flow Chemistry (2015)

Although photocatalytic chemistry has been the subject of intense interest recently, the rate of these reactions is often slow due to the limited penetration of light into typical reaction media. Peter H. Seeberger at the Max-Planck Institute for Colloids and Surfaces in Potsdam and the Free University of Berlin showed (Chem. Sci. 2012, 3, 1612) that Ru(bpy)32+-catalyzed reactions such as the reduction of azide 1 to 2 can be achieved in as little as 1 min residence time using continuous flow, as opposed to the 2 h batch reaction time previously reported. The benefits of flow on a number of strategic photocatalytic reactions, including the coupling of 3 and 4 to produce 5, was also demonstrated (Angew. Chem. Int. Ed. 2012, 51, 4144) by Corey R.J. Stephenson at Boston University and Timothy F. Jamison at MIT. In this case, a reaction throughput of 0.914 mmol/h compares favorably with 0.327 mmol/h for the batch reaction. Professor Seeberger has also reported (Angew. Chem. Int. Ed. 2012, 51, 1706) a continuous-flow synthesis of Artemisinin 7, a highly effective antimalarial drug, starting from dihydroartemisinic acid 6. The conversion occurs by a sequence of photochemical oxidation with singlet oxygen, acidic Hock cleavage of the O–O bond, and oxidation with triplet oxygen, a process calculated to be capable of furnishing up to 200 g/day per reactor. A scalable intramolecular [2 + 2] photocycloaddition of 8 to produce 9 was reported (Tetrahedron Lett. 2012, 53, 1363) by Matthias Nettekoven of Hoffmann-La Roche in Basel, Switzerland. Stephen L. Buchwald at MIT developed (Angew. Chem. Int. Ed. 2012, 51, 5355) a flow process for the enantioselective β-arylation of ketones that involved lithiation of aryl bromide 10, borylation, and rhodium-catalyzed conjugate addition to cycloheptenone. For continuous flow production of enantioenriched alcohols such as 14, Miquel A. Pericás of the Institute of Chemical Research of Catalonia developed (Org. Lett. 2012, 14, 1816) the robust polystyrene-supported aminoalcohol 13 for diethylzinc addition to aldehydes. Professor Jamison found (Org. Lett. 2012, 14, 568) that flow chemistry provides a convenient and reliable solution to the reduction of esters to aldehydes with DIBALH (e.g., 15 to 16) that occurs rapidly and without the usual problem of overreduction.
Amino-functionalized carbon nanotubes as solid basic catalysts for the transesterification of triglycerides (2009)

Multiwalled carbon nanotubes grafted with various amino groups show high activity and stability when used as basic catalysts for the transesterification of triglycerides.
Awake measures of nasal resistance and upper airway resistance on CPAP during sleep. (2011)

Awake measurements of nasal resistance do not seem to be predictive of upper airway resistance during sleep on CPAP.
Application of Hybrid Fuzzy Logic Controller to Keep a Standing Wave Angular Position in MEMS Rate Gyroscope (2018)

This paper considers application of fuzzy logic controller (FLC) to compensate for the Coriolis force in rate MEMS gyroscope. Comparative investigation of hybrid FLC-PI, FLC-PID and classical PI and PID controllers has been made to find advantages of any of those controllers under measurement of accumulated angle during shock and step response parameters. In this paper, from four controllers which can be used to control parameters of MEMS gyro, only one is under investigation that responsible for keeping a standing wave in the fix angular position providing accurate angle rate measurement. Hybrid controllers' advantages in presence of noise have been shown.
A Probabilistic Approach to Address TCP Incast in Data Center Networks (2011)

Data centers typically host tens of thousands of servers that communicate with each other using high speed network interconnects. While these servers help in servicing millions of clients, their overall performance largely depends on the efficiency of the center's communication fabric. Cost and compatibility reasons however, persuade many data centers to consider Ethernet for their baseline communication fabric. Until recently, Ethernet speeds inside data centers averaged around 100Mbps but the evolution of IEEE 802.3 standards has led to the development of 1 Gbps and 10 Gbps Ethernet. This sudden jump in Ethernet speeds requires proportional scaling of TCP/IP processing for network intensive applications to really benefit from the increased bandwidth. While IP is expected to scale well in this context, TCP is known to have problems supporting very high data rates at very low latencies. One such problem, termed the `Incast', results in gross under-utilization of link capacity in certain many-to-one TCP communication patterns. This paper presents a practical solution to TCP's incast problem. Our proposed technique relies on a probabilistic approach that augments TCP's standard congestion recovery mechanism. Simulation results demonstrate that this technique is effective in avoiding TCP throughput collapse in data center networks.
Stereocontrolled Routes to 4-Methoxypentadienoates for Use in Natural Product Synthesis (2013)

Mild and efficient routes to (<i>E</i>,<i>E</i>)- and (<i>E</i>,<i>Z</i>)-4-methoxypentadienoic acid esters from readily accessible γ,δ-epoxydienoates are described. The crucial epoxide methanolysis can be carried out in stereocomplementary ways by the use of either acid-mediated or palladium-catalysed procedures, the latter procedure proving ­preferable in most cases.
AC transport current loss characteristics of twisted multifilament Bi/Ag sheathed tape subject to AC longitudinal magnetic field (2002)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation J. Ogawa, O. Tsukamoto, M. Ciszek, N. Amemiya, S. Fukui; AC transport current loss characteristics of twisted multifilament Bi/Ag sheathed tape subject to AC longitudinal magnetic field. AIP Conf. Proc. 15 May 2002; 614 (1): 740–747. https://doi.org/10.1063/1.1472610 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Zoos: Valuable Adjuncts for the Instruction of Animal Behavior (1971)

Journal Article Zoos: Valuable Adjuncts for the Instruction of Animal Behavior Get access Duane M. Rumbaugh Duane M. Rumbaugh Search for other works by this author on: Oxford Academic Google Scholar BioScience, Volume 21, Issue 15, 1 August 1971, Pages 806–809, https://doi.org/10.2307/1295653 Published: 01 August 1971 Article history Accepted: 23 April 1971 Published: 01 August 1971
Caloric Intake and the Risk of Alzheimer Disease (2002)

Higher intake of calories and fats may be associated with higher risk of AD in individuals carrying the apolipoprotein E epsilon4 allele.
Circulating cell-free mRNA in plasma as a tumor marker for patients with primary and recurrent gastric cancer. (2007)

Detection of circulating cell-free mRNA might serve as a new complementary tumor marker for gastric cancer.
Diverging curvature correction to the interfacial tension in polymer solutions (2008)

Application of polymer scaling to the problem of Tolman's length, a curvature correction coefficient in the interfacial tension, shows that Tolman's length in polymer solutions may become as large as half of the thickness of the interface. Tolman's length depends on the degree of polymerization N and the distance to the critical point of phase separation, Delta T. In the "critical" regime (N 1/2|Delta T|<<1) Tolman's length diverges upon approach to the critical temperature as approximately N 0.348|Delta T|-0.304. In the "polymer" regime (N 1/2|Delta T|>> 1) Tolman's length does not depend on N , but diverges more strongly, as approximately |Delta T|-1, proportional to the thickness of the interface.
Thermodynamic nature of the antiferromagnetic transition inNaxCoO2 (2006)

High-resolution thermal expansion measurements of single-crystalline ${\mathrm{Na}}_{0.80}\mathrm{Co}{\mathrm{O}}_{2}$ reveal continuous behavior of the paramagnetic-antiferromagnetic phase transition at ${T}_{M}=21.7(1)\phantom{\rule{0.3em}{0ex}}\mathrm{K}$ with critical exponent $\ensuremath{\alpha}=0.18(2)$. The thermal expansion is found to be highly anisotropic. Thermodynamic analysis provides the hydrostatic pressure derivative $d{T}_{M}∕dP=+4.6(2)\phantom{\rule{0.3em}{0ex}}\mathrm{K}∕\mathrm{GPa}$. Similar measurements and analysis are presented for ${\mathrm{Na}}_{0.75}\mathrm{Co}{\mathrm{O}}_{2}$.
Transvaginal ultrasound and sonohysterography for assessment of postpartum residual trophoblastic tissue (2010)

Although SHG showed greater accuracy than transvaginal ultrasound in detecting residual trophoblastic tissue, a high proportion of patients experienced adverse effects.
Electrocyclic Reactions in Stereoselective Synthesis (2013)

The stereochemical course of electrocyclic reactions is determined by the orbital symmetry rules. This makes it possible to make predictions of the stereochemical outcome of such carbon–carbon, bond‐forming processes with much greater confidence than can usually be made in the case of reactions proceeding through other mechanisms. Although the potential of these reactions in total synthesis has long been recognized, only recently have the asymmetric catalyzed versions of some of these reactions been developed. A broad overview of this area with emphasis on methods with strong potential in natural products synthesis has been presented in this chapter.
Endoplasmic reticulum proteostasis in glioblastoma—From molecular mechanisms to therapeutic perspectives (2017)

Cellular stress induced by the accumulation of misfolded proteins at the endoplasmic reticulum (ER) is a central feature of secretory cells and is observed in many tissues in various diseases, including cancer, diabetes, obesity, and neurodegenerative disorders. Cellular adaptation to ER stress is achieved by the activation of the unfolded protein response (UPR), an integrated signal transduction pathway that transmits information about the protein folding status at the ER to the cytosol and nucleus to restore proteostasis. In the past decade, ER stress has emerged as a major pathway in remodeling gene expression programs that either prevent transformation or provide selective advantage in cancer cells. Controlled by the formation of a dynamic scaffold onto which many regulatory components assemble, UPR signaling is a highly regulated process that leads to an integrated reprogramming of the cell. In this Review, we provide an overview of the regulatory mechanisms underlying UPR signaling and how this pathway modulates cancer progression, particularly the aggressiveness and chemotherapeutic resistance exhibited by glioblastoma, a form of brain cancer. We also discuss the emerging cross-talk between the UPR and related metabolic processes to ensure maintenance of proteostasis, and we highlight possible therapeutic opportunities for targeting the pathway with small molecules.
Abstract A164: Targeting PDK1 in breast cancer: Kinase-dependent regulation of tumor growth and kinase-independent regulation of cell migration and invasion. (2013)

Abstract 3-Phosphoinositide Dependent Kinase 1 (PDK1) is the kinase that phosphorylates the activation loop of several protein kinases such as Akt, PKC or SGK. In breast carcinomas PDK1 was found frequently overexpressed and this correlates with a more aggressive phenotype. This study is aimed to understand the role of PDK1 in breast tumor progression and the molecular mechanisms involved. Using stable gene silencing and kinase inhibitors we studied PDK1 role in different in vitro and in vivo assays including anchorage independent growth, anoikis, xenografts, migration and invasion assays. In our study we found that PDK1 promotes resistance to anoikis, anchorage independent growth and tumor growth in breast cancer cell lines through the phosphorylation of its substrates, since the kinase-dead mutant abrogates all the PDK1-mediated effects. For this reasons either PDK1 gene silencing or its chemical kinase inhibition are sufficient to promote anoikis, to reduce anchorage independent growth and tumor growth. We also found that PDK1 silencing is able to reduce, while its overexpression to increase cell migration and invasion in mammary cells. Surprisingly, the regulation of cell migration is operated in a kinase independent manner, in fact PDK1 kinase inhibitor failed to recapitulate the effects of gene silencing in cell migration. The molecular mechanism, underlying this unconventional kinase-independent regulation of cell migration involves the binding of PDK1 to Myotonic Dystrophy kinase-related Cdc42-binding Kinase α (MRCKα). This binding increases MRCKα kinase activity on Myosin Light Chain-2 (MLC2) and on myosin phosphatase target subunit 1 (MyPT1). Both these phosphorylations promote increase of non-muscular myosin activity, which is required to pull forward the cell body during directional migration and invasion. In summary, our findings unveil that PDK1 regulates tumor growth, survival in absence of adhesion, resistance to anoikis, but also migration and invasion of breast cancer cells by two different mechanisms. These findings should be taken in account for a rational targeting of PDK1 in cancer. Citation Information: Mol Cancer Ther 2013;12(11 Suppl):A164. Citation Format: Paolo Armando Gagliardi, Laura di Blasio, Giorgio Seano, Roberto Sessa, Alberto Puliafito, Federico Bussolino, Luca Primo. Targeting PDK1 in breast cancer: Kinase-dependent regulation of tumor growth and kinase-independent regulation of cell migration and invasion. [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2013 Oct 19-23; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2013;12(11 Suppl):Abstract nr A164.
Rapid Synthesis of High Surface Area Imine‐Linked 2D Covalent Organic Frameworks by Avoiding Pore Collapse During Isolation (2019)

Imine-linked 2D covalent organic frameworks (COFs) form more rapidly than previously reported under Brønsted acid-catalyzed conditions, showing signs of crystallinity within a few minutes, and maximum crystallinity within hours. These observations contrast with the multiday reaction times typically employed under these conditions. In addition, vacuum activation, which is often used to isolate COF materials significantly erodes the crystallinity and surface area of the several isolated materials, as measured by N<sub>2</sub> sorption and X-ray diffraction. This loss of material quality during isolation for many networks has historically obscured otherwise effective polymerization conditions. The influence of the activation procedure is characterized in detail for three COFs, with the commonly used 1,3,5-tris(4-aminophenyl)benzene-terephthaldehyde network (TAPB-PDA COF), the most prone to pore collapse. When the networks are activated carefully, rapid COF formation is general for all five of the imine-linked 2D COFs studied, with all exhibiting excellent crystallinity and surface areas, including the highest surface areas reported to date for three materials. Furthermore, to simplify the workup of COF materials, a simple nitrogen flow method provides high-quality materials without the need for specialized equipment. These insights have important implications for studying and understanding how 2D COFs form.
A Survey on Methods for finding Min-Cut Tree (2013)

In this paper we have discussed all existing approaches to solve the problem for calculating the min-cut tree of an undirected edge-weighted graph and present a new approximation algorithm for constructing the minimum-cut tree. We discussed Gomory-Hu algorithm. The algorithm proposed by Gomory and Hu has time complexity O(V*time complexity of finding a min s-t cut). We also have discussed Ford-Fulkerson method. Running time of Ford-Fulkerson algorithm is O(ve 2). The asymptotically fastest maximumflow algorithms are based on push-relabel method and have the running time of O(V 3). M. Stoer and F. Wagner have given a simple and compact algorithm for finding the minimum cut of a graph. The algorithm is remarkably simple and has the fastest running time so far the algorithm consists of |V |- 1 identical phases each of which requires O(|e | + |V| log |V|) time yielding an overall running time of O(|V||e | + log |V|). We present a new approximation algorithm for constructing the minimum cut tree. We calculate an upperbound value for each node in the graph. We define the upper bound value of each node as the value of cut which separates this node from rest of the graph and our algorithm runs in O(V 2.logV + V 2.d), where V is the number of vertices in the given graph and d is the degree of the graph. It is a significant improvement over time complexities of existing solutions. However, because of an assumption it does not produce correct result for all sorts of graphs but for the dense graphs success rate is more than 90%. Moreover in the unsuccessful cases, the deviation from actual result is very less (usually for less than 5 % pairs) and for most of the pairs we obtain correct values of max-flow or min-cut. Keywords Undirected edge-weighted graph; min-cut tree; dense graphs; max-flow; min-cut 1.