gebhart/patrepeval huggingface dataset:
The measurement of elongation of anterior cruciate-ligament grafts in vivo. (1994)

Many investigators who have studied the mechanical behavior of anterior cruciate-ligament grafts have attributed the increase in anterior translation of the tibia relative to the femur (an increase in the anterior laxity of the knee joint) to the temporal changes in the material behavior (strength and elastic properties) of the graft that occur throughout the process of remodeling. However, with the onset of motion of the joint, it is unclear whether the repeatable mechanical behavior of the graft remains unchanged immediately after fixation, if the fixation slips, or if the length of the graft changes and produces an increase in anterior translation of the tibia relative to the femur. It is also unknown if procedures performed by different surgeons, using similar graft material and similar operative techniques, can produce similar mechanical behavior of the graft, or if the behavior of the graft is similar to that of the normal anterior cruciate ligament. In an effort to address these questions, two surgeons performed a reconstruction of the anterior cruciate ligament on ten patients each (groups 1 and 2) with use of a bone-patellar ligament-bone graft. Immediately after fixation of the graft, a Hall-effect transducer was implanted to measure the changes in the length of the mid-substance of the graft while the knee was moved through twenty cycles of passive flexion-extension. Unlike the length pattern of the normal anterior cruciate ligament, the length pattern of the graft changed during the initial cycles of passive motion of the knee. We defined this phenomenon as the cyclic response of the graft and characterized it by calculation of the changes in the length of the graft at fixed positions of the knee across the multiple cycles of passive motion. In some patients, the length of the graft increased through the initial passive-motion cycles, while in others, it decreased. With the knee nearly extended, the predicted increase in anterior translation of the tibia relative to the femur, resulting from the increase in the length of the graft, was a maximum of 1.0 millimeter. This indicates that increases in anterior translation of the tibia relative to the femur can occur immediately after reconstruction of the anterior cruciate ligament and that changes in the length of the graft occur after fixation at loads that are less than the ultimate failure load of the graft or of the fixation.(ABSTRACT TRUNCATED AT 400 WORDS)
Evaluation Studies of Combined Wavelet and Neural Network Applications in High Voltage Transmission Line Protection (2014)

This paper presents a critical evaluation of the combination of the wavelet transform and neural network techniques into high voltage transmission line protection. These techniques are used to enhance the ability to discriminate between different types of fault at any point of the protected line, relying on only single-ended measurement of the induced transient information of the fault. The main objective is to locate the faults and discriminate the fault type; this has been done by analysing the three phase voltage and current signals measured with CTs and VTs. For signal analysis, the wavelet transform has been used due to the ability to decompose a signal from low frequency to high frequency without losing the information in the time domain. Neural networks have been introduced as a powerful tool for accurate pattern classification. A Modular Neural Network (MNN) has been used to optimize the structure of an artificial neural network for a short training time and hardware implementation.
Predictors of Myocardial Infarction after Distal Embolization of Coronary Vessels with Percutaneous Transluminal Coronary Angioplasty (1994)

Of 1,855 patients with angina pectoris who underwent percutaneous transluminal coronary angioplasty (PTCA) in our hospital, 21 experienced distal embolization. Five of the patients had slow washout of contrast medium distal to the dilated stenosis accompanied by S-T segment elevation (slow-flow pattern). In the other 16 cases, a dislodged embolus was found distal to the dilated stenosis (occlusive pattern) following balloon inflation. Of the 21 patients, 8 (38%) developed acute myocardial infarction (MI). All patients with acute MI were thought to have intraluminal thrombus on angiography performed before PTCA. Interestingly, patients with recent MI or worsening angina had a significantly higher rate of acute MI (p < 0.05).
A transposon-based strategy to identify the regulatory gene network responsible for landomycin E biosynthesis (2013)

We report here a transposon-based strategy to generate Streptomyces globisporus 1912 mutants with improved landomycin E production. The modified minitransposon with strong, outward-oriented promoters for the overexpression of downstream-situated genes has been applied for mutant library generation. Approximately 2500 mutants of S. globisporus 1912 were analyzed for landomycin E production, leading to the identification of several overproducers. Subcloning and sequencing of the sites of integration showed that some of the inactivated genes encode proteins with a similarity to known bacterial regulators such as TetR and LuxR families. One of the regulators (GntR type) has shown the strongest influence on the landomycin E production. Its ortholog (encoded by sco3269) in Streptomyces coelicolor was characterized in greater detail and showed similar effects on actinorhodin production and morphological differentiation.
Clinical usefulness of the metabolic syndrome for the risk of coronary heart disease does not exceed the sum of its individual components in older men and women. The Three-City (3C) Study (2012)

The MetS is a risk marker for CHD in community-dwelling elderly subjects but may not be useful for CHD risk prediction purposes compared to its individual components.
[Treatment of AL amyloidosis without myeloma]. (1988)

AL amyloidosis is a serious complication of monoclonal gammopathy. The therapeutic strategy in amyloidosis associated with myeloma is to decrease the amyloidogenic precursor synthetised by the monoclonal plasmocytic proliferation. However, when systemic amyloidosis complicates a so called "benign" monoclonal gammopathy, this therapeutic approach is debatable. We report 10 cases of AL amyloidosis without myeloma treated by chemotherapy. Eight patients were initially given alkylating agents (cyclophosphamide or melphalan) which had no effect on the clinical progression of their systemic amyloidosis or on the plasma concentrations of the precursor. A limited open clinical trial including 4 patients was then undertaken based on the Vincristine, Adriamycine, Dexamethasone combination recently proposed for cases of resistant myeloma. A 50% reduction in the serum monoclonal protein was observed in 2 patients with this treatment. However, the mean survival of the 10 patients (25 months) was not longer than that previously reported for patients receiving more conventional treatment. The results of this limited trial indicate the need for further controlled therapeutic trials with larger numbers of patients in order to assess the effect of polychemotherapy in patients with AL amyloidosis.
The role of laparoscopy in the management of pancreatic cancer (1998)

Video laparoscopy has undergone significant advancements in the past several years. This technology can be applied to the management of patients with pancreatic carcinoma. Laparoscopy can be used to achieve the following goals when treating patients with pancreatic cancer: (1) to accurately stage the disease including diagnosis of intraperitoneal and extrapancreatic disease, (2) to evaluate resectability, (3) in resectional therapy and, (4) in palliation of unresectable disease. This chapter reviews in detail these four applications of the laparoscopic surgical approach in the management of patients with pancreatic carcinoma.
A new quinolinone and its natural/artificial derivatives from a shark gill-derived fungus Penicillium polonicum AP2T1 (2015)

Four quinolinones (1-4; 1 is a new compound) were isolated from the static fermentation culture of a shark gill-derived fungus Penicillium polonicum AP2T1. In addition, five new quinolinone derivatives (5-9) and also 1 were obtained in a trimethylsilyldiazomethane-induced methylation reaction of 4. Their structures were elucidated by spectroscopic analyses. In bioassays, compounds 7 and 5 with lactim structures moderately inhibited the proliferation of human cancer cell line HCT116 (wild-type) with IC<sub>50</sub>-24 h of 8.4 μg/mL and 30.7 μg/mL, respectively; the other compounds displayed weaker inhibition. The p53 gene may play some role in their action as suggested by their much weakened activity towards p53-knockout HCT116 cell line. Besides, 6 and 8 exhibited moderate or weak toxicity to brine shrimp larvae, and 3, 4, 8 and 9 showed weak inhibition against Staphylococcus aureus. It is the first report on elucidation of new compounds with origin of shark-derived fungi.
The relevance of the polymicrobial nature of airway infection in the acute and chronic management of patients with cystic fibrosis. (2009)

A comprehensive analysis of the airway microbiome in cystic fibrosis (CF) has revealed that the airways are a reservoir of previously unrecognized but clinically relevant organisms. Traditionally, antibiotic intervention in patients with CF presenting with acute bronchopulmonary exacerbations has been directed at a limited number of bacterial pathogens. In patients chronically colonized by conventional pathogens that demonstrate no bacteriological response to standard therapy, other antibiotics may have clinical efficacy. Using a case-based example, this review argues that pathogen-directed treatment based on inclusive quantitative microbiological protocols can result in improved patient outcomes. Furthermore, future therapeutic approaches that may rely on a polymicrobial perspective of the airways in CF are discussed.
Temperature-Driven Twin Structure Formation and Electronic Structure of Epitaxially Grown Mg3Sb2 Films on Mismatched Substrates (2022)

Mg<sub>3</sub>Sb<sub>2</sub>-based compounds are one type of important room-temperature thermoelectric materials and the appropriate candidate of type-II nodal line semimetals. In Mg<sub>3</sub>Sb<sub>2</sub>-based films, compelling research topics such as dimensionality reduction and topological states rely on the controllable preparation of films with high crystallinity, which remains a big challenge. In this work, high quality Mg<sub>3</sub>Sb<sub>2</sub> films are successfully grown on mismatched substrates of sapphire (000<i>l</i>), while the temperature-driven twin structure evolution and characteristics of the electronic structure are revealed in the as-grown Mg<sub>3</sub>Sb<sub>2</sub> films by in situ and ex situ measurements. The transition of layer-to-island growth of Mg<sub>3</sub>Sb<sub>2</sub> films is kinetically controlled by increasing the substrate temperature (<i>T</i><sub>sub</sub>), which is accompanied with the rational manipulation of twin structure and epitaxial strains. Twin-free structure could be acquired in the Mg<sub>3</sub>Sb<sub>2</sub> film grown at a low <i>T</i><sub>sub</sub> of 573 K, while the formation of twin structure is significantly promoted by elevating the <i>T</i><sub>sub</sub> and annealing, in close relation to the processes of strain relaxation and enhanced mass transfer. Measurements of scanning tunneling spectroscopy (STS) and angle-resolved photoemission spectroscopy (ARPES) elucidate the intrinsic p-type conduction of Mg<sub>3</sub>Sb<sub>2</sub> films and a bulk band gap of ~0.89 eV, and a prominent Fermi level downshift of ~0.2 eV could be achieved by controlling the film growth parameters. As elucidated in this work, the effective manipulation of the epitaxial strains, twin structure and Fermi level is instructive and beneficial for the further exploration and optimization of thermoelectric and topological properties of Mg<sub>3</sub>Sb<sub>2</sub>-based films.
Myth, reality and requirements in pharmaceutical Key Account Management (2009)

Key Account Management (KAM) is an important approach to the development and maintenance of large accounts, especially in the mature market conditions found in many pharmaceutical and related businesses. However, the meaning and practice and KAM has been blurred and weakened by misuse of the term. This paper begins with a brief description of the history of the subject before it moves on to identify, based on prior research, five characteristic features that differentiate KAM from traditional sales management. Finally, the paper places these characteristic features into the specific context of pharmaceutical market management, identifying five requirements for the application of KAM in pharmaceutical and related markets.
Use of capnography for prediction of obstruction severity in non-intubated COPD and asthma patients (2021)

clinical trials.gov, NCT02805114. Registered 17 June 2016, https://clinicaltrials.gov/ct2/show/NCT02805114.
An iterative, multi-level, and scalable approach to comparing execution traces (2007)

In this paper, we overview a new approach to comparing execution traces. Such comparison can be useful for purposes such as improving test coverage and profiling system's users. In our approach, traces are compressed into different levels of compaction and are then compared iteratively from highest to lowest levels, rejecting dissimilar traces in the process and eventually leaving residual, similar traces. These residual traces form an important feedback for improvement or analysis goals. The preliminary results show that the approach is scalable for industrial use.
On Puncturing Strategies for Polar Codes (2017)

This paper introduces a class of specific puncturing patterns, called symmetric puncturing patterns, which can be characterized and generated from the rows of the generator matrix $G_N$. They are first shown to be non-equivalent, then a low-complexity method to generate symmetric puncturing patterns is proposed, which performs a search tree algorithm with limited depth, over the rows of $G_N$. Symmetric patterns are further optimized by density evolution, and shown to yield better performance than state-of-the-art rate compatible code constructions, relying on either puncturing or shortening techniques.
Reactions of 5‐Mercaptoazoles and Pyridine‐2‐thiones with Acetylenic Esters. Selectivity of the Formation of Novel Fused Thiazin‐4‐ones and Thiazolidin‐4‐ones. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Endogenous angiogenesis inhibitors (2004)

When the FDA commissioner announced in February 2004 the approval of Avastin for the treatment of patients with colon cancer, he called angiogenesis inhibitors a fourth modality of anti-cancer therapy. Because angiogenesis inhibitors are relatively less toxic than conventional chemotherapy and have a lower risk of drug resistance, they may also represent a new class of anti-cancer agents, some of which have sufficiently reduced toxicity that they may be safely used long term. These include immunotherapy, vaccines, telomerase inhibitors, apoptosis inducers, low dose metronomic chemotherapy, novel hormonal therapies, gene therapy and others. However, at least 16 endogenous angiogenesis inhibitors have been discovered in the circulation, and/or in the extracellular matrix. These may become the safest and least toxic of anti-cancer therapies. Four are already being administered by injection in clinical trials for cancer. Recently, it has been reported that at least two endogenous angiogenesis inhibitors can be significantly increased in humans (endostatin), and in mice (thrombospondin), by oral administration of small molecules which themselves are already FDA approved for other uses. This finding suggests several new clinical applications for the future, including the possibility of guiding the use of angiogenesis inhibitors by blood or urinary biomarkers, currently being developed, that may detect the presence of cancer before it is symptomatic, or before it can be located by conventional methods.
Synthesis and antihypertensive activity of some 2-aminobenzimidazole and indole derivatives. (1991)

The synthesis of some 2-aminobenzimidazole and indole amide derivatives containing a 2,6-dichloroaniline moiety is described. The preparation of a theophylline derivative is also reported. All the compounds tested showed no appreciable antihypertensive activity on spontaneously hypertensive rats.
The Karyotype of the Hoatzin (<b><i>Opisthocomus hoazin</i></b>) - A Phylogenetic Enigma of the Neornithes (2018)

The hoatzin (Opisthocomus hoazin Müller, 1776) is a folivorous bird, endemic to the Amazonian region. It presents some unique characteristics, including wing claws and foregut fermentation, which make its phylogenetic relationship to other birds difficult to determine. There have been various attempts to place it among the Galliformes, Gruiformes, Musophagiformes, Cuculiformes, and Charadriiformes, but phylogenetic analyses always show low supporting values. Nowadays, the hoatzin is included in the monotypic order Opisthocomiformes, but the relationship of this order to other groups of birds is still unclear. Although its karyotype resembles the typical avian model, fissions of the syntenic groups corresponding to chicken chromosomes 1 and 2 and 2 fusions were found. The presence of 18S rDNA clusters in 2 pairs of microchromosomes is another derived character. Hence, different rearrangements were detected in the karyotype of the hoatzin, indicating it has been derived from the putative ancestral karyotype by the occurrence of fissions and fusions. However, as these rearrangements are not exclusive to O. hoazin, they do not clarify the phylogenetic position of this enigmatic species.
Immunotargeting of collagenase on thrombus (2010)

In this study, we aimed to develop a thrombus-targeting delivery system of collagenase bound to a monoclonal antibody, and to investigate the thrombolysis of an immune-conjugate in vitro and in vivo as well as the targeting effect. We prepared the immunizing conjugation of collagenase by the 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDCI) method. In order to conjugate collagenase and a monoclonal antibody, bovine serum albumin was used as a linker, increasing the number of collagenase molecules carried and keeping collagenase and the monoclonal antibody active. In vitro thrombolysis experiments showed that collagenase had a strong dissolving effect on collagen-embolus within 24 hours. We established a rabbit pulmonary embolism model to investigate the thrombolysis effect of collagenase and collagenase immunizing conjugation in vivo. Our results revealed a significant difference between collagenase and collagenase immunizing conjugation (P < 0.05). We also established a rabbit ear edge vein model to investigate the active target of collagenase immunizing conjugation. We found that collagenase immunizing conjugation had active targets, and had a strong ability to dissolve organized thrombi. In conclusion, the thrombus-targeting delivery system of collagenase we developed has active targeting effects on thrombi.
Effect of Heat Treatment on Magnetic Properties of SmCo 2∶17 Type Alloy (2008)

The Sm(Co.Fe,Cu,Zr)z(6.5z8.5) sintered magnets were prepared by powder metallurgy,the magnets with same prepare condition and composition respectively annealing in different temperature and time,measure results indicate that the way of heat treatment effect on the magnetic properties in evidence.The optimum remanence Br at temperate 835℃ annealing for 8 hours and coercive force is increased with the increase of annealing temperature and time.In the end,the kinetics mechanism have been discussed.
Impact of Percutaneous Revascularization on Exercise Hemodynamics in Patients With Stable Coronary Disease (2018)

In patients with SCD and severe single-vessel stenosis, objective physiological responses to exercise immediately normalize following PCI. This is seen in the coronary circulation, the microcirculation, and systemic hemodynamics.
Stereochemistry of the Bucherer–Bergs and Strecker Reactions of 4-tert-Butylcyclohexanone (1975)

The spirohydantoin (α-isomer) obtained from 4-tert-butylcyclohexanone by the Bucherer–Bergs reaction has been shown by n.m.r., u.v., and considerations of steric hindrance to have the tert-butyl group and 1′-nitrogen atom cis; the β isomer obtained via the Strecker reaction, or via modified Bucherer–Bergs reactions employing carbon disulfide or carbon oxysulfide, has these groups trans. The differing stereochemical courses of the various reactions can be explained by a detailed consideration of their mechanisms.
Early characteristics of Sturge-Weber syndrome shown by perfusion MR imaging and proton MR spectroscopic imaging. (2003)

We report the case of a 9-month-old boy with Sturge-Weber syndrome and new onset of seizure. Perfusion MR imaging showed early changes compatible with impaired venous drainage in the affected hemisphere, whereas proton MR spectroscopic imaging revealed a focal parietal area of elevated choline without significant alteration of N-acetylaspartate levels. The perfusion and subtle metabolic abnormalities are comparable with the extent of the overlying leptomeningeal enhancement, illustrating the early pathophysiological manifestation of this disease.
Proton transport through acid aggregates in a hydrated precise sulfophenylated polyethylene (2019)

International audience
Acaricide resistance mechanisms in Rhipicephalus (Boophilus) microplus (2012)

Acaricide resistance has become widespread in countries where cattle ticks, Rhipicephalus (Boophilus) microplus, are a problem. Resistance arises through genetic changes in a cattle tick population that causes modifications to the target site, increased metabolism or sequestration of the acaricide, or reduced ability of the acaricide to penetrate through the outer protective layers of the tick's body. We review the molecular and biochemical mechanisms of acaricide resistance that have been shown to be functional in R. (B.) microplus. From a mechanistic point of view, resistance to pyrethroids has been characterized to a greater degree than any other acaricide class. Although a great deal of research has gone into discovery of the mechanisms that cause organophosphate resistance, very little is defined at the molecular level and organophosphate resistance seems to be maintained through a complex and multifactorial process. The resistance mechanisms for other acaricides are less well understood. The target sites of fipronil and the macrocyclic lactones are known and resistance mechanism studies are in the early stages. The target site of amitraz has not been definitively identified and this is hampering mechanistic studies on this acaricide.