gebhart/patrepeval huggingface dataset:
GW150914: First results from the search for binary black hole coalescence with Advanced LIGO (2016)

On September 14, 2015 at 09:50:45 UTC the two detectors of the Laser Interferometer Gravitational-wave Observatory (LIGO) simultaneously observed the binary black hole merger GW150914. We report the results of a matched-filter search using relativistic models of compact-object binaries that recovered GW150914 as the most significant event during the coincident observations between the two LIGO detectors from September 12 to October 20, 2015. GW150914 was observed with a matched filter signal-to-noise ratio of 24 and a false alarm rate estimated to be less than 1 event per 203000 years, equivalent to a significance greater than 5.1 <i>σ</i>.
Streptovirudins of series I and II: chemical and biological properties (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStreptovirudins of series I and II: chemical and biological propertiesAlan D. Elbein, John L. Occolowitz, Robert L. Hamill, and Klaus EckardtCite this: Biochemistry 1981, 20, 14, 4210–4216Publication Date (Print):July 1, 1981Publication History Published online1 May 2002Published inissue 1 July 1981https://pubs.acs.org/doi/10.1021/bi00517a040https://doi.org/10.1021/bi00517a040research-articleACS PublicationsRequest reuse permissionsArticle Views72Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Diagnosing degenerate forms in software (2014)

The degeneration of source code due to maintenance is a long known but little understood phenomenon. Currently, researchers face significant logistical challenges when conducting empirical studies and experiments, studying large-scale projects, and characterizing the development and growth of degenerative forms. These logistical challenges can be partially alleviated by developing automated metrics designed to identify degenerate forms. Furthermore, such metrics are essential for targeted refactoring and repairing degenerative forms. This dissertation research investigates a set of metrics targeted at specific degenerate forms common in software. The successful implementation and characterization of such metrics will enable further research in many forms of software maintenance.
DNA methyltransferase 3B (DNMT3B) mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development, neurogenesis and immune function (2007)

Genome-wide DNA methylation patterns are established and maintained by the coordinated action of three DNA methyltransferases (DNMTs), DNMT1, DNMT3A and DNMT3B. DNMT3B hypomorphic germline mutations are responsible for two-thirds of immunodeficiency, centromere instability, facial anomalies (ICF) syndrome cases, a rare recessive disease characterized by immune defects, instability of pericentromeric satellite 2-containing heterochromatin, facial abnormalities and mental retardation. The molecular defects in transcription, DNA methylation and chromatin structure in ICF cells remain relatively uncharacterized. In the present study, we used global expression profiling to elucidate the role of DNMT3B in these processes using cell lines derived from ICF syndrome and normal individuals. We show that there are significant changes in the expression of genes critical for immune function, development and neurogenesis that are highly relevant to the ICF phenotype. Approximately half the upregulated genes we analyzed were marked with low-level DNA methylation in normal cells that was lost in ICF cells, concomitant with loss of repressive histone modifications, particularly H3K27 trimethylation, and gains in transcriptionally active H3K9 acetylation and H3K4 trimethylation marks. In addition, we consistently observed loss of binding of the SUZ12 component of the PRC2 polycomb repression complex and DNMT3B to derepressed genes, including a number of homeobox genes critical for immune system, brain and craniofacial development. We also observed altered global levels of certain histone modifications in ICF cells, particularly ubiquitinated H2AK119. Therefore, this study provides important new insights into the role of DNMT3B in modulating gene expression and chromatin structure and reveals new connections between DNMT3B and polycomb-mediated repression.
Immucillin H, a powerful transition-state analog inhibitor of purine nucleoside phosphorylase, selectively inhibits human T lymphocytes (2001)

Transition-state theory has led to the design of Immucillin-H (Imm-H), a picomolar inhibitor of purine nucleoside phosphorylase (PNP). In humans, PNP is the only route for degradation of deoxyguanosine, and genetic deficiency of this enzyme leads to profound T cell-mediated immunosuppression. This study reports the biological effects and mechanism of action of Imm-H on malignant T cell lines and on normal activated human peripheral T cells. Imm-H inhibits the growth of malignant T cell leukemia lines with the induction of apoptosis. Imm-H also inhibits activated normal human T cells after antigenic stimulation in vitro. However, Imm-H did not inhibit malignant B cells, colon cancer cell lines, or normal human nonstimulated T cells, demonstrating the selective activity of Imm-H. The effects on leukemia cells were mediated by the cellular phosphorylation of deoxyguanosine and the accumulation of dGTP, an inhibitor of ribonucleotide diphosphate reductase. Cells were protected from the toxic effects of Imm-H when deoxyguanosine was absent or when deoxycytidine was present. Guanosine incorporation into nucleic acids was selectively blocked by Imm-H with no effect on guanine, adenine, adenosine, or deoxycytidine incorporation. Imm-H may have clinical potential for treatment of human T cell leukemia and lymphoma and for other diseases characterized by abnormal activation of T lymphocytes. The design of Imm-H from an enzymatic transition-state analysis exemplifies a powerful approach for developing high-affinity enzyme inhibitors with pharmacologic activity.
Structure and properties of the slags of continuous converting of copper nickel-containing mattes and concentrates: III. Influence of the slag composition on the surface tension and density of slag melts (2012)

The surface tension and density of the slags that form during the continuous converting of copper mattes and concentrates into blister copper are determined. The slag melt compositions are varied over a wide range of (Fe + Ni) concentrations and SiO2/CaO and (Fe)/(Cu + Ni) ratios. The surface tension and density are measured by the bubble pressure technique. The concentration of iron and nickel in a slag and the (Fe)/(Cu + Ni) and SiO2/CaO ratios affect the density and surface tension.
Entrainment Techniques for Mapping Atrial and Ventricular Tachycardias (1995)

Many atrial tachycardias, atrial flutter, and postmyocardial infarction ventricular tachycardias are due to reentry through large "macroreentrant" circuits. These circuits can be difficult to define by catheter mapping of the activation sequence. Entrainment techniques allow the relation of a mapping site to the reentrant circuit to be assessed on a site-by-site basis during catheter mapping. Regions of abnormal conduction that are in the reentrant circuit can be distinguished from bystander sites outside the circuit. A mapping site classification to guide catheter ablation is reviewed.
Parents' intention for their children to receive COVID-19 vaccine: Implications for vaccination program in Macao (2022)

Vaccinating children with COVID-19 vaccine is a complex decision-making for parents. A key to a successful COVID-19 vaccination program is effective communication about the safety profile and the usage experiences warranting the integration of reliable information sources across different healthcare sectors.
Simultaneous measurement of group refractive index and thickness of optical samples using optical coherence tomography (2010)

Optical coherence tomography (OCT), based on a Michelson interferometer and utilizing low coherence light as the optical source, is a novel technique for the noninvasive imaging of optical scattering media. A simple OCT scheme based on a 3 x 3 fiber coupler is presented for the simultaneous measurement of the refractive index and thickness of optical samples. The proposed system enables the refractive index and thickness to be determined without any prior knowledge of the sample parameters and is characterized by a simple and compact configuration, a straightforward measurement procedure, and a low cost. The feasibility of the proposed approach is demonstrated experimentally using BK7 and B270 optical glass samples.
Autonomous Fueled Mechanical Replication of Nucleic Acid Templates for the Amplified Optical Detection of DNA (2006)

Fuel for a DNA machine: A FokI enzyme/DNA scission machine is triggered by the hybridization of its DNA hairpin structure with a target nucleic acid. The machine is fueled by a secondary fluorophore (F)- and quencher (Q)-functionalized nucleic acid 2. Scission of 3 leads to replication of the machinery cutter 1 and yields a fluorescent product 6, which provides an optical output for the machine (see scheme). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z503810_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Viral-mediated gene therapy in combination with temozolomide in melanoma (2012)

Egger, Michael E. MD; Gomez-Gutierrez, J. G. PhD; Hao, H. PhD; Zhou, H. S. PhD; McMasters, Kelly M. MD, PhD, FACS Author Information
Transcriptional profiling of three key genes of terpenoid indole alkaloid pathway in Catharanthus roseus under different tissue culture conditions (2014)

The response of three key genes: strictosidine synthase (str1), tryptophan decarboxylase (tdc) and secologanin synthase (cyp72A1) of the wild plant species, Catharanthus roseus to different plant tissue culture treatments was studied. These genes encode enzymes acting early in the biosynthetic pathway of terpenoid indole alkaloids. In vitro culture system conditions involved the application of three sucrose (40, 50 and 60 g/L), three benzyl adenine (0.1, 0.2 and 0.4 mg/L) and two jasmonic acid (10 and 100 &micro;M) concentrations. Quantitative RT-PCR (qRT-PCR) using SYBR Green I was used to analyze the changes in expression of the three genes in response to different media recipes. The maximum folding of str1 expression (1.9x) between treated and untreated callus was obtained under ba2 (0.2 mg/L benzyl adenine) treatment. Relatively high folding values of 1.8x and 1.7x were obtained in S2 (50 g/L sucrose) and ba1 (0.1 mg/L benzyl adenine), respectively. Two-fold increase in gene expression of tdc was obtained when C. roseus callus was treated with 10 &micro;M jasmonic acid (ja1), while only 1.5x was obtained when callus was treated with 100 &micro;M jasmonic acid (Ja2). The maximum expression of cyp72A1 gene (4.6x) was observed under ba2 treatment, when the callus was treated with 0.2 mg/L benzyl adenine. This emphasized the influence of BA on up-regulation of this gene. &nbsp; Key words: Strictosidine synthase, tryptophan decarboxylase, secologanin synthase, Catharanthus roseus, terpenoid indole alkaloids.
In vivo stimulation of neutrophil function by lenograstim (glycosylated rHug‐CSF) in oncohematologic patients: Results of a phase I trial (1994)

The aim of this work was to study the evolution of neutrophil functions in non-neutropenic cancer patients. Thirty non-neutropenic patients, median age 35 years (range 19-52), with solid tumors (n = 21) or lymphomas (n = 9) entered a phase I study of five days of s.c. (n = 24) or i.v. bolus (n = 6) lenograstim, recombinant human glycosylated granulocyte colony-stimulating factor (rHuG-CSF Chugai-Rhône-Poulenc), with dose escalation from 1 to 40 micrograms/kg/day. Neutrophil functions were studied before lenograstim (D1) and 24 h after the last dose (D6). Granulocyte count rose in a significant way, and enzyme release, phagocytosis and bacterial killing were stimulated. All patients had improvement of at least one neutrophil function. Directed migration was depressed, although it was still in the normal range. These findings confirm that lenograstim is a potent activator of neutrophil functions in non-neutropenic cancer patients and may be useful as an adjunct to conventional antimicrobial therapy.
Development and Validation of a Liquid Chromatography-Mass Spectrometry Assay for the Quantitation of IPTG in E. Coli Fed-Batch Cultures (2010)

IPTG (Isopropyl-beta-d-1-thiolgalactopyranoside) is a gratuitous inducer commonly used for the overexpression of heterologous recombinant proteins in Escherichia coli. A reliable method has been developed for the determination of IPTG in E.coli fed-batch fermentation samples with a minimal sample treatment. Analysis was performed in single ion monitoring positive mode using ESI source. The extracted ion was 261 m/z and the retention time of IPTG was 12.4 min with a total run time in samples of 30 min. The flow was directed to mass spectrometer 11 min after the start of the run and diverted from mass spectrometer after 14.5 min in order to avoid interference of salts and other metabolites. The assay was validated for medium and intracellular matrices and linear calibration curves of 3 orders of magnitude were obtained (R(2) >or= 0.99). Quality control samples were analyzed and showed precision and accuracy within the limits according to FDA Guidelines for analytical method validation. Recovery for both matrices was between 95.8 and 113.5%. The limit of detection (LOD) was set at 0.02 microM being the 0.1% of the lowest IPTG concentration used for induction of recombinant protein overexpression. The developed procedure has been applied to determine the IPTG distribution profiles in medium and intracellular samples in high cell density induced cultures for the production of the recombinant protein rhamnulose-1-phosphate aldolase (RhuA).
Verapamil-induced changes in central conduction in patients with multiple sclerosis. (1985)

The electrophysiological characteristics of demyelinated axons are sensitive to changes in plasma calcium concentration. This study investigated the effect of verapamil, a calcium antagonist drug, on brainstem auditory, visual, and somatosensory evoked potentials in multiple sclerosis patients. Eight clinically stable patients with abnormal visual and/or brainstem auditory evoked potentials and four normal volunteers were studied. During intravenous infusions of verapamil (mean plasma concentration = 130.0 +/- 56.4 ng/ml), the latencies of peaks III and V were shortened (p less than 0.05) in multiple sclerosis patients with abnormally prolonged BAEPs. The I-III (delta = 0.08 ms), III-V (delta = 0.46 ms), and I-V (delta = 0.53 ms) interpeak intervals, and the P100 latency (delta = 10.15 ms) of the visual evoked potential were similarly affected in these patients. In contrast, normal evoked potentials of both multiple sclerosis patients and control subjects were not altered compared to baseline recordings obtained 24 hours earlier. Intravenous verapamil, therefore, alters the BAEPs and VEPs of some multiple sclerosis patients with demyelinated auditory and visual pathways by shortening pathologically prolonged latencies toward normal. The present study suggests pharmacological manipulation of calcium-dependent processes, possibly at the level of the demyelinated axon, can acutely facilitate central conduction of electrical impulses in some patients with clinically stable multiple sclerosis.
An optical add-drop multiplexer (OADM) node architecture in a fully transparent self healing network (1996)

A novel optical add-drop multiplexer node architecture, with ultra fast self healing mechanism. In an unidirectional ring is presented. A system model to evaluate the effect of the crosstalk and EDFA noise accumulation on transmission performances is proposed. BER estimation in a closed ring architecture has been evaluated.
Production of Doubly Charged Helium Ions by Two-Photon Absorption of an Intense Sub-10-fs Soft X-Ray Pulse at 42 eV Photon Energy (2005)

We report on the observation of doubly charged helium ions produced by a nonlinear interaction between a helium atom and photons with a photon energy of 42 eV which are generated with the 27th harmonic of a femtosecond pulse from a Ti:sapphire laser. The number of ions is proportional to the square of the intensity of the 27th harmonic pulse, and thus two-photon double ionization should be dominantly induced as compared with other nonlinear processes accompanying sequential ionization via a singly charged ion. This phenomenon is utilized to measure the pulse duration of the 27th harmonic pulse by using an autocorrelation technique, for the first time to our knowledge, and as a result a duration of 8 fs is found.
CDDO-imidazolide Targets Multiple Amino Acid Residues on the Nrf2 Adaptor, Keap1 (2020)

Synthetic triterpenoids including CDDO, its methyl ester (CDDO-Me, bardoxolone methyl), and its imidazolide (CDDO-Im) enhance Nrf2-mediated antioxidant and anti-inflammatory activity in many diseases by reacting with thiols on the adaptor protein, Keap1. Unlike monofunctional CDDO-Me, the bifunctional analog, CDDO-Im, has a second reactive site (imidazolide) and can covalently bind to amino acids other than cysteine on target proteins such as glutathione S-transferase pi (GSTP), serum albumin, or Keap1. Here we show for the first time that bifunctional CDDO-Im (in contrast to CDDO-Me), as low as 50 nM, can covalently transacylate arginine and serine residues in GSTP and cross-link them to adjacent cysteine residues. Moreover, we show that CDDO-Im binds covalently to Keap1 by forming permanent Michael adducts with eight different cysteines, and acyl adducts with lysine and several tyrosine residues. Modeling studies suggest that the Tyr 85 adduct stabilizes the Keap1-Cul3 complex, thereby enhancing the potency of CDDO-Im.
Competing kinetic pathways in the bromine addition to allylic ethers in 1,2‐dichloroethane: Opposite temperature effects (2007)

Abstract The kinetics of the electrophilic bromination of three allylic ethers in a nonprotic solvent, 1,2‐dichloroethane, has been investigated. Two of them followed a prevalent second‐order pathway, while the third one exhibited a classical, clean third order. The second‐order pathway in the first two olefins is attributed to electrophilic assistance of the ethereal oxygen to the attacking bromine molecule. In the molecular bromination of 2,4‐ cis ‐dimethyl‐8‐oxabicyclo[3.2.1]‐6‐octen‐3‐ cis ‐ol, opposite temperature dependences were found for the two different kinetic pathways. An exoergonic process for the second‐order reaction was explained by the lesser stability of the bromiranium–bromide ionic intermediate, compared to the bromiranium–tribromide in the third‐order profile. © 2007 Wiley Periodicals, Inc. 39: 197–203, 2007
Bimolecular Extrusion of TeR2 from β-Diketiminato Supported Scandium Bis-tellurolates (2000)

Reaction of the well-defined, base-free dialkyl scandium compounds LnSc(CH2SiMe3)2 supported by the β-diketiminato ligands ArNC(R)CHC(R)NAr (Ar=2,6-diisopropyl; R=Me, L1; R=tBu, L2) with two equivalents of nBu3P=Te gives the bis-tellurolate complexes LnSc(TeCH2SiMe3)2, 1 b (L1) and 2 b (L2). Tellurolate 2 b was isolated and fully characterized, including an X-ray structure analysis, and exhibits two chemically distinct tellurolate ligands in solution on the NMR time scale. Tellurolate 1 b is only moderately stable and decomposes with elimination of two equivalents of Te(CH2SiMe3)2 to form the dimeric bis-telluride 1 d. This compound was characterized by X-ray crystallography and elemental analysis. In contast, tellurolate 2 b decomposes with loss of only one equivalent of Te(CH2SiMe3)2, leading to the formation of a dinuclear complex with one bridging telluride unit joining two L2Sc(TeCH2SiMe3) fragments. This compound was also structurally characterized. The solution behavior of this material is complex, as it exists as three conformational isomers that undergo slow exchange on the NMR time scale. The production of dimer 2 c, along with the results of crossover experiments, suggest strongly that TeR2 elimination from these bis-tellurolates is bimolecular.
Darstellung und spektroskopische Eigenschaften einiger Perbromierter und periodierter Oligosilane (1982)

Abstract Die Spaltung von Oktaphenylcyclotetrasilan und Dekaphenylcyclopentasilan mit Iod, Phosphorpentabromid oder Brom und anschließende Umsetzung mit HBr/AlBr 3 bzw. HI/AlI 3 erlaubt die Darstellung der bisher unbekannten Halogensilane n‐Si 4 Br 10 , n‐Si 4 I 10 , n‐Si 5 Br 12 und n‐Si 5 I 12 . Ihre IR‐ und Raman‐Spektren werden mit Hilfe einer Normalkoordinatenanalyse diskutiert. Jene der kürzlich dargestellten [1] cyclischen Iodsilane Si 4 I 8 , Si 5 I 10 und Si 6 I 12 werden mit einbezogen.
Aerodynamic testing of a smart composite wing using fiber-optic strain sensing and neural networks (2000)

The feasibility of developing a smart wing using composite materials, fiber-optic sensors, and neural networks is investigated. Strain and aerodynamic lift force induced in a wing model at different air speeds and angles-of-attack are experimentally determined in an open circuit wind tunnel. The smart wing model consisted of a glass/epoxy composite beam with an interferometric fiber-optic sensor mounted at the wing root. The strains were correlated to the set of air velocities and angles-of-attack using a feedforward backpropagation neural network approach. The resulting neural network simulation could predict the experimental strain in real time with an average error of 3.17%. Finite-element analysis prediction of aerodynamic lift calculated using measured strain at the wing root generally agreed with thin airfoil theory, the differences being attributed to uncertainty in composite material properties.
Trends in Preparation of New Angiographic Contrast Media with Special Emphasis on Polymeric Derivatives (1970)

Professor of Radiology, Neurological Institute, Columbia–Presbyterian Medical Center, New York, N. Y.