gebhart/patrepeval huggingface dataset:
Li−Biphenyl−1,2-Dimethoxyethane Solution:  Calculation and Its Application (2006)

Metallic lithium reacts with biphenyl in 1,2-dimethoxyethane (DME) solvent at room temperature. This reaction has been studied using density functional theory (DFT) at the B3LYP level together with the 6-311++G (d,p) basis set. From the energy results of the corresponding optimized geometries for intermediate complexes, the reaction can be interpreted as a charge-transfer process between lithium and biphenyl followed by Li+ coordination with ether oxygens in DME. In addition, the experimentally observed vibrational bands can be unambiguously assigned and interpreted according to the normal modes calculated for the biphenyl-Li-DME complex. This organic complex solution has been demonstrated as a very effective chemical lithiation agent. V2O5 can be lithiated up to 1.45 lithium ions per formula. The lithiated V2O5 shows a high Li-extraction capacity of 173 mAh/g as cathode material for lithium ion batteries.
Microemulsions as Flowback Aids for Enhanced Oil and Gas Recovery after Fracturing, Myth or Reality: A Turnkey Study to Determine the Features and Benefits (2015)

Abstract Flowback aids have been long reported in the literature as being beneficial to enhance clean-up after stimulation treatments, and in particular hydraulic fracturing. The goal is for the flowback aids to allow the piston like flowback and return of fluids from the reservoir resulting in minimal losses to the formation and no memory effect that hampers back production. Microemulsions have also been reported in the literature and a review (including patent landscape) creates somewhat of a myth around their exact mechanism of performance and benefit to the application. The present work was concerned with the development of flowback aids based on micro-/nano-emulsion technology for enhanced gas and oil recovery after fracturing application. The goal was to formulate microemulsion concentrates which form nanoemulsions when diluted into fracturing fluids and provide strong surface and interfacial tension reduction to minimize reservoir damage. Microemulsions have been formulated with various possible surfactants and oil systems. The performance of the different formulations has been evaluated with different test methods, adopted from literature and industry best practice in order to screen for most promising microemulsion systems and compared to their aqueous equivalents to determine the performance benefits offered by emulsified packages. High throughput experimentation and robotic formulation was utilized to screen several thousand formulations from nearly 50 different surfactant packages. This allowed for incredible synergistic properties to be discovered very quickly and efficiently. The development of a new class of microemulsion package that is made up of almost 100% renewable and environmentally friendly components has made a large step change towards the state of the art of this class of flowback aids. Regain permeability and core flow testing was performed on the best performing microemulsion formulations to determine the effect of field application. The result of this work was that microemulsions do offer some benefits over individual surfactants, not so much in surface tension modification but very much on the non-emulsification of crude oil and water and multiphase flow in porous media – so often seen as the primary damage mechanism in oil well fracturing.
Lyn Is an Important Component of the Signal Transduction Pathway Specific to FLT3/ITD and Can Be a Therapeutic Target in the Treatment of AML with FLT3/ITD. (2006)

Abstract Fms-like tyrosine kinase 3 (FLT3) is expressed in hematopoietic progenitor cells. An internal tandem duplication (ITD) of the FLT3 juxtamembrane domain (FLT3/ITD) is the most frequent mutation in human adult acute myeloid leukemia (AML). Being transfected into IL-3 dependent cell line, 32D, FLT3/ITD causes constitutive activation of FLT3 itself and its downstream signal components, which leads to IL-3 independent cell growth. In particular, STAT5 activation is thought to be a key signaling event since it is induced only by FLT3/ITD not by wild type FLT3. However the signal component which mediates FLT3/ITD to STAT5 is yet to be clarified. In the present study, we showed the mutant- specific association of FLT3/ITD with Lyn, which led to the phosphorylation of Lyn in vivo. We also demonstrated that Lyn directly bound to FLT3 through its SH2 domain in vitro and that the association depended on tyrosyl-phosphorylation at juxtamembrane domain of FLT3. We revealed the critical role of Lyn for STAT5 activation and the autonomous cell growth in FLT3/ITD transfectant of 32D by using anti-Lyn siRNA and the Src family kinase inhibitor PP2. More importantly, we demonstrated successful treatment of FLT3/ITD induced tumors with PP2 in the mice model. These results demonstrate that Lyn is a critical component of the signal transduction pathway specific to FLT3/ITD and can be a therapeutic target in the treatment of AML with FLT3/ITD.
Run-time correlation engine for system monitoring and testing (2009)

We present an approach and implementation for run-time correlation of large volumes of log data and symptom matching of know issues in the context of large enterprise applications. Our solution provides for (a) automatic data collection, (b) data normalisation into a common format, (c) run time correlation and analysis of the data to give a coherent view of system behaviour at run-time and (d) a symptom matching mechanism that can identify known errors in the correlated data on the fly. We have implemented our approach in the form of the Run-Time Correlation Engine (RTCE) and have applied it in a real industry test.
Electrical and Optical Properties of a Novel Nonconjugated Conductive Polymer, Polynorbornene (2009)

We report electrical and optical properties of a novel nonconjugated conductive polymer, polynorbornene which has an isolated double bond in the repeat. Electrical conductivity of this polymer increases by twelve orders of magnitude to about 0.01 S/cm upon doping with iodine. Optical absorption measurements of the polymer film have been made at different dopant concentrations. For a lightly doped polymer, two absorption peaks: one corresponding to cation radicals and the other corresponding to charge transfer between the double bond and the dopant were observed at 4.20 eV (295 nm) and 3.13 eV (396 nm) respectively. FTIR spectroscopic measurements have shown reduction in the intensities of the C═C stretching and ═C─H bending vibration bands upon doping indicating formation of radical cations. Photoluminescence studies have shown an emission band with a major peak at ∼422 nm when excited at 280 nm. The peaks in the photoluminescence spectrum are consistent with the vibration bands observed in the FTIR spectrum.
Chromosomes 12 and 16 workshop (1999)

Recent linkage results independently derived from a large French Canadian pedigree and Danish kindreds coupled with supportive data from other studies provide compelling evidence for a bipolar disorder susceptibility locus on chromosome 12q23-q24. The idea is further strengthened by the finding that Darier's disease, which maps to this region, has been shown to cosegregate with affective disorder in a family. This linkage finding, however, was not supported in other independent genome scans. On chromosome 16, bipolar families from Denmark exhibited suggestive linkage with D16S510, on 16p13. Multipoint nonparametric analysis on the NIMH Genetics Initiative bipolar pedigrees yielded increased allele sharing that maximized ∼18 cM proximal to the latter locus. In contrast, evidence of linkage was not detected in other panels of bipolar families that were presented. At 16p13, a maximum multipoint lod score of 4 for a latent class-derived phenotype that has aspects of alcohol dependence was found in a genome scan of 105 families from the Collaborative Study of the Genetics of Alcoholism, identifying a potential vulnerability locus. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 88:255–259, 1999. Published 1999 Wiley-Liss, Inc.
Real-time soft error rate measurements on bulk 40 nm SRAM memories: a five-year dual-site experiment (2016)

International audience
Formation of pyrroles, 2-pyrrolidones, and pyridones by heating of 4-aminobutyric acid and reducing sugars (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFormation of pyrroles, 2-pyrrolidones, and pyridones by heating of 4-aminobutyric acid and reducing sugarsRoland. Tressl, Evelyn. Kersten, and Dieter. RewickiCite this: J. Agric. Food Chem. 1993, 41, 11, 2125–2130Publication Date (Print):November 1, 1993Publication History Published online1 May 2002Published inissue 1 November 1993https://pubs.acs.org/doi/10.1021/jf00035a057https://doi.org/10.1021/jf00035a057research-articleACS PublicationsRequest reuse permissionsArticle Views348Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Recombinant yeast with improved ethanol tolerance and related methods of use (2023)

The present invention provides isolated Elo1 and Mig3 nucleic acid sequences capable of conferring increased ethanol tolerance on recombinant yeast and methods of using same in biofuel production, particularly ethanol production. Methods of bioengineering yeast using the Elo1 and, or, Mig3 nucleic acid sequences are also provided.
LIAeq100ms, An A-duration adjusted impulsive noise damage risk criterion (2015)

Impulsive noise damage risk criteria (DRCs) have been the subject of much debate nationally and internationally for more than 30 years. Several approaches have been used in proposed DRCs including: curves defining exposure based on peak level and A or B duration; auditory hazard units based on the analytical auditory model known as AHAAH; and LAeq metrics based on the equal energy concept. Each of the approaches has positive and negative attributes. One of the issues with LAeq metrics has been the over estimation of hazard with long duration impulses such as those coming from blasts, artillery, large mortars, or shoulder launched missiles. The presentation will describe and discuss the LIAeq100ms impulsive DRC which includes an adjustment based on the A-duration of the impulsive noise and a method of computing protected impulsive noise exposures using impulsive insertion loss data from hearing protectors measured with methods defined in ANSI S12.42.
Thyroxine analogs. XVII. 3,5-Bis(ethylthio)- and 3,5-bis(phenylthio)-DL-thyronines and their 3'-isopropyl analogs (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThyroxine analogs. XVII. 3,5-Bis(ethylthio)- and 3,5-bis(phenylthio)-DL-thyronines and their 3'-isopropyl analogsEugene C. Jorgensen, Richard O. Muhlhauser, and Robert A. WileyCite this: J. Med. Chem. 1969, 12, 4, 689–691Publication Date (Print):July 1, 1969Publication History Published online1 May 2002Published inissue 1 July 1969https://doi.org/10.1021/jm00304a029RIGHTS & PERMISSIONSArticle Views28Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (398 KB) Get e-Alerts Get e-Alerts
Chapter 1 (2009)

In 1949, shortly after the Communists took over the reins of mainland China, Frances Wong went back to Guangzhou (or Canton), the capital of south China, from the British colony of Hong Kong. At that time, communications between Guangzhou and Hong Kong were disrupted because the Kowloon-Canton Railway was jointly owned by the Hong Kong and Chinese governments, and with the taking over of Guangzhou by the Communists, it took some time before new rules and regulations of the railway were ironed out by the authorities. So Wong walked all the way for seven days. Wong admits to being naïve, adventurous, romantic, a little patriotic and also primarily, because her husband decided to go and she thought it was her duty to go with him. This chapter goes back to Wongs' childhood, love for poetry, and traces how her thoughts and character developed.
Antifungal agents. VIII. Synthesis and antifungal activities of bipyrryl analogues of bifonazole. (1994)

Various bipyrryl analogues of bifonazole were synthesized starting from aryl-3-pyrryl-1-imidazolylmethanes. The introduction of a second pyrryl portion was performed by linking an acrylate moiety at 1-position of the pyrrole ring and then by treatment with TosMIC. The bipyrryl esters were hydrolyzed and decarboxylated to afford the required imidazoles. All new imidazole derivatives were tested against Candida albicans and Candida spp using as standard controls miconazole, bifonazole and ketoconazole.
RAD‐Seq derived markers flank the shell colour and banding loci of the Cepaea nemoralis supergene (2013)

Studies on the classic shell colour and banding polymorphism of the land snail Cepaea played a crucial role in establishing the importance of natural selection in maintaining morphological variation. Cepaea is also a pre-eminent model for ecological genetics because the outward colour and banding phenotype is entirely genetically determined, primarily by a 'supergene' of at least five loci. Unfortunately, progress in understanding the evolution and maintenance of the Cepaea polymorphism stalled, partly because of a lack of genetic markers. With a view to re-establish Cepaea as a prominent model of molecular ecology, we made six laboratory crosses of Cepaea nemoralis, five of which segregated for shell ground colour (C) and the presence or absence of bands (B). First, scoring of colour and banding in 323 individuals found no recombination between the C and B loci of the supergene. Second, using restriction site-associated DNA sequencing (RAD-Seq) of two parents and 22 offspring, we identified 44 anonymous markers putatively linked to the colour (C) and banding (B) loci. The genotype of eleven of the most promising RAD-Seq markers was independently validated in the same 22 offspring, then up to a further 146 offspring were genotyped. The closest RAD-Seq markers scored are within ~0.6 centimorgan (cM) of the C-B supergene linkage group, with the combined loci together forming a 35.8 cM linkage map of markers that flank both sides of the Cepaea C-B supergene.
Greater prevalence of PROKR2 mutations in Kallmann syndrome patients from the Maghreb than in European patients (2013)

The great prevalence of PROKR2 mutations in Maghrebian patients has practical consequences for molecular diagnosis of the disease and genetic counseling in the Maghrebian population.
Reinforcement Learning inspired Deep Learned Compositional Model for Decision Making in Tracking (2018)

We formulate a tracker which performs incessant decision making in order to track objects where the objects may undergo different challenges such as partial occlusions, moving camera, cluttered background etc. In the process, the agent must make a decision on whether to keep track of the object when it is occluded or has moved out of the frame temporarily based on its prediction from the previous location or to reinitialize the tracker based on the belief that the target has been lost. Instead of the heuristic methods we depend on reward and penalty based training that helps the agent reach an optimal solution via this partially observable Markov decision making (POMDP). Furthermore, we employ deeply learned compositional model to estimate human pose in order to better handle occlusion without needing human inputs. By learning compositionality of human bodies via deep neural network the agent can make better decision on presence of human in a frame or lack thereof under occlusion. We adapt skeleton based part representation and do away with the large spatial state requirement. This especially helps in cases where orientation of the target in focus is unorthodox. Finally we demonstrate that the deep reinforcement learning based training coupled with pose estimation capabilities allows us to train and tag multiple large video datasets much quicker than previous works.
ORGANOSILICON POLYMER COMPOUNDS BASED INORGANIC FIBERS FOR HIGH-TEMPERATURE COMPOSITE MATERIALS (review) (2019)

Рассмотрены основные типы неорганических волокон, производящихся за рубежом, на основе кремнийорганических полимерных прекурсоров для высокотермостойких композиционных материалов различной природы. Кратко описаны способы получения прекурсоров и волокон на их основе, а также показано влияние природы исходного полимера и способа получения волокон на их физико-механические свойства, фазовый состав и термоокислительную устойчивость. Показаны перспективы применения волокон в качестве армирующего наполнителя для высокотермостойких композитов.
Quantitative PCR for Determining the Infectivity of Bacteriophage MS2 upon Inactivation by Heat, UV-B Radiation, and Singlet Oxygen: Advantages and Limitations of an Enzymatic Treatment To Reduce False-Positive Results (2009)

Health risks posed by waterborne viruses are difficult to assess because it is tedious or impossible to determine the infectivity of many viruses. Recent studies hypothesized that quantitative PCR (qPCR) could selectively quantify infective viruses if preceded by an enzymatic treatment (ET) to reduce confounding false-positive signals. The goal of this study was to determine if ET with qPCR (ET-qPCR) can be used to accurately quantify the infectivity of the human viral surrogate bacteriophage MS2 upon partial inactivation by three treatments (heating at 72 degrees C, singlet oxygen, and UV radiation). Viruses were inactivated in buffered solutions and a lake water sample and assayed with culturing, qPCR, and ET-qPCR. To ensure that inactivating genome damage was fully captured, primer sets that covered the entire coding region were used. The susceptibility of different genome regions and the maximum genomic damage after each inactivating treatment were compared. We found that (i) qPCR alone caused false-positive results for all treatments, (ii) ET-qPCR significantly reduced (up to >5.2 log units) but did not eliminate the false-positive signals, and (iii) the elimination of false-positive signals differed between inactivating treatments. By assaying the whole coding region, we demonstrated that genome damage only partially accounts for virus inactivation. The possibility of achieving complete accordance between culture- and PCR-based assays is therefore called into doubt. Despite these differences, we postulate that ET-qPCR can track infectivity, given that decreases in infectivity were always accompanied by dose-dependent decreases in ET-qPCR signal. By decreasing false-positive signals, ET-qPCR improved the detection of infectivity loss relative to qPCR.
TWIK-2, a New Weak Inward Rectifying Member of the Tandem Pore Domain Potassium Channel Family (1999)

Potassium channels are found in all mammalian cell types, and they perform many distinct functions in both excitable and non-excitable cells. These functions are subserved by several different families of potassium channels distinguishable by primary sequence features as well as by physiological characteristics. Of these families, the tandem pore domain potassium channels are a new and distinct class, primarily distinguished by the presence of two pore-forming domains within a single polypeptide chain. We have cloned a new member of this family, TWIK-2, from a human brain cDNA library. Primary sequence analysis of TWIK-2 shows that it is most closely related to TWIK-1, especially in the pore-forming domains. Northern blot analysis reveals the expression of TWIK-2 in all human tissues assayed except skeletal muscle. Human TWIK-2 expressed heterologously in Xenopus oocytes is a non-inactivating weak inward rectifier with channel properties similar to TWIK-1. Pharmacologically, TWIK-2 channels are distinct from TWIK-1 channels in their response to quinidine, quinine, and barium. TWIK-2 is inhibited by intracellular, but not extracellular, acidification. This new clone reveals the existence of a subfamily in the tandem pore domain potassium channel family with weak inward rectification properties.
Improvement of Recalcitrant Diabetic Macular Edema After Peritoneal Dialysis (2017)

Nephropathy may be an independent and contributory risk factor for diabetic macular edema (DME). A 69-year-old man who had previously been treated with panretinal laser photocoagulation for proliferative diabetic retinopathy as well as with steroid and anti-vascular endothelial growth factor injections for DME declined additional treatment for the DME, which was worse in the right eye. The DME was observed without further treatment for the next 36 months. Despite well-controlled blood sugar, blood pressure, and lipid levels, the DME remained unchanged. Peritoneal dialysis was started due to end-stage renal disease. Three months after commencing dialysis, the DME improved significantly. [Ophthalmic Surg Lasers Imaging Retina. 2017;48:834-837.].
Recent developments in PROGRESS (1997)

The least median of squares (LMS) regression method is highly robust to outliers in the data. It can be computed by means of PROGRESS (from Program for RObust reGRESSion). After ten years we have developed a new version of PROGRESS, which also computes the least trimmed squares (LTS) method. We will discuss the various new features of PROGRESS, with emphasis on the algorithmic aspects.
Mechanism for fetal globin gene expression: Role of the soluble guanylate cyclase-cGMP-dependent protein kinase pathway (2001)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.