gebhart/patrepeval huggingface dataset:
Allergic and Pseudo‐allergic Reactions Caused by Penicillins, Cocoa and Peppermint Additives in Penicillin Factory Workers Examined by Basophil Histamine Release (1984)

Allergic and pseudo-allergic reactions were examined in penicillin factory workers exposed to the dust of preparations of pivampicillin and pivmecillinam. Among 14 workers basophils from five persons showed histamine release by challenge with penicillins, whereas no release was observed in controls of non-atopic individuals not working with the manufacturing of penicillin. Positive skin response was obtained in four workers by path testing and in three persons by scratch test revealing late but no immediate response. All the eight workers who were also exposed to flavour additives used in the penicillin preparations showed histamine release by cocoa and peppermint. The release was not changed by removal of immunoglobulins from the basophil cell surface and the additives caused a similar release in the controls. The histamine release caused by cocoa and peppermint therefore depend on non-immunological mechanisms, i.e. pseudo-allergic reactions which might contribute to the symptoms in penicillin factory workers.
Solid-state Reaction and Benzene Removal Activities of Composite Powders in Ni-La-Al2O3 System. (1997)

The Solid-state reaction, sintering and hydrocarbon-removal activities of composite powders in La-Ni-Al2O3 system were studied toward their application to heat-stable exhaust catalyst. The different routes with the impregnation technique were applied to prepare the composite powders. X-ray diffraction revealed the following solid-state reactions; γ-Al2O3 (+NiO) + La2O3 (500°C)→γ-Al2O3 (+NiO) + LaAlO3 (800-1000°C)→γ-Al2O3 (+NiO) + LaAlO3 + NiLaAl11O19 (1000-1100°C). The La-stabilization was effective to retain large surface areas of these composite powders. The C6H6 removal activities were compared for the Ni-La-Al2O3, heated at 800°C and 1000°C. The catalytic performance depended on microstructures in the La-Ni-A12O3 composite powders from different routes.
A New Synthesis of (±)-Canadaline (1979)

I-Canadaline was synthesized using a regioselective N-C8 bond cleavage of tetrahydroberberine with ethyl chloroformate.Canadaline (?I ,l an alkaloid isolated from Hydrastis canadensis L, is representative of a new group of isoquinoline alkaloids, the secoberbines.2In 1978, Shamma =.' reported the first synthesis of its racemate from the Hofmann degradation 3 product ( 2 ) of 8-benzyltetrahydroberberine.We now wish to report an alternative and convenient synthesis of (?)-canadaline y & a regioselective N-C8 bond cleavage of tetrahydroberberine itself.In boiling ethyl chloroformate, tetrahydroberberine (31 gave the urethane ($1 in 1 ,
Virulence Factors Involved in the Pathogenesis of the Infection Caused by the Swine Pathogen and Zoonotic Agent Streptococcus Suis (2012)

Streptococcus suis is a major swine pathogen responsible for important economic losses to the swine industry worldwide. It is also an emerging zoonotic agent of meningitis and streptococcal toxic shock-like syndrome. Since the recent recognition of the high prevalence of S. suis human disease in southeast and east Asia, the interest of the scientific community in this pathogen has significantly increased. In the last few years, as a direct consequence of these intensified research efforts, large amounts of data on putative virulence factors have appeared in the literature. Although the presence of some proposed virulence factors does not necessarily define a S. suis strain as being virulent, several cell-associated or secreted factors are clearly important for the pathogenesis of the S. suis infection. In order to cause disease, S. suis must colonize the host, breach epithelial barriers, reach and survive in the bloodstream, invade different organs, and cause exaggerated inflammation. In this review, we discuss the potential contribution of different described S. suis virulence factors at each step of the pathogenesis of the infection. Finally, we briefly discuss other described virulence factors, virulence factor candidates and virulence markers for which a precise role at specific steps of the pathogenesis of the S. suis infection has not yet been clearly established.
Anterior Cervical Osteotomy for Fixed Cervical Deformities (2014)

4.
Voxel Placement Precision for GABA-Edited Magnetic Resonance Spectroscopy (2017)

The purpose of the present study was to assess the reproducibility of voxel placement for GABA-edited MRS. GABA-edited MRS data were acquired in 13 healthy volunteers from (3 cm)<sup>3</sup> voxel; and within the same session a second acquisition was independently prescribed. A three-dimensional voxel mask image was reconstructed in T1-image-space using the SVMask tool (in house software). Reproducibility of voxel placement was assessed using the Dice overlap coefficient, both within-subject and between-subject following co-registration of T1 images and transformation of voxel mask images to standard space. Within-subject overlap coefficients were 86% ± 5%. Between-subject overlap coefficients were 75% ± 10%. For the two voxel locations considered (occipital and sensorimotor), voxel overlap was very similar. Between-subject values are higher due to between-session effects, anatomical variability and volume mismatch in standard space. While surprisingly low in terms of volume overlap, the overlap coefficients correspond to acceptable linear displacements.
24‐Epi‐makisterone a (not makisterone A) is the major ecdysteroid in the leaf‐cutting ant Acromyrmex octospinosus (reich) (hymenoptera, formicidae: Attini) (1993)

Abstract The chemical nature of the major ecdysteroid from pupae of the leaf‐cutting ant Acromyrmex octospinosus has been reinvestigated. On the basis of reversed phase high performance liquid chromatography and mass spectrometry, this compound was previously identified as makisterone A [Maurer et al., Arch Insect Biochem Physiol 16 , 1 (1991)] but a more careful examination has led to the conclusion that it is in fact 24‐epi‐makisterone A. This finding stresses the limits of criteria used for the identification of ecdysteroids and the possible need for reexamination of makisterone A identification in some other species feeding on a 24β‐methyl sterol source. © 1993 Wiley‐Liss, Inc.
Supplementary Information from Rab25 Is a Tumor Suppressor Gene with Antiangiogenic and Anti-Invasive Activities in Esophageal Squamous Cell Carcinoma (2023)

&lt;p&gt;PDF file, 153K, Supplementary Materials and Methods, Tables, Figure Legends, References&lt;/p&gt;
The effect of dispersion on spectral broadening of incoherent continuous-wave light in optical fibers (2010)

In addition to fiber nonlinearity, fiber dispersion plays a significant role in spectral broadening of incoherent continuous-wave light. In this paper we have performed a numerical analysis of spectral broadening of incoherent light based on a fully stochastic model. Under a wide range of operating conditions, these numerical simulations exhibit striking features such as damped oscillatory spectral broadening (during the initial stages of propagation), and eventual convergence to a stationary, steady state spectral distribution at sufficiently long propagation distances. In this study we analyze the important role of fiber dispersion in such phenomena. We also demonstrate an analytical rate equation expression for spectral broadening.
A decomposition storage model (1985)

article Free Access Share on A decomposition storage model Authors: George P. Copeland Microelectronics And Technology Computer Corporation, 9430 Research Blvd, Austin, Texas Microelectronics And Technology Computer Corporation, 9430 Research Blvd, Austin, TexasView Profile , Setrag N. Khoshafian Microelectronics And Technology Computer Corporation, 9430 Research Blvd, Austin, Texas Microelectronics And Technology Computer Corporation, 9430 Research Blvd, Austin, TexasView Profile Authors Info & Claims ACM SIGMOD RecordVolume 14Issue 4May 1985 pp 268–279https://doi.org/10.1145/971699.318923Published:01 May 1985Publication History 307citation2,303DownloadsMetricsTotal Citations307Total Downloads2,303Last 12 Months178Last 6 weeks45 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Impact of Organic Templates on the Selective Formation of Zeolite Oligomers (2020)

Zeolites are essential materials to industry due to their adsorption and catalytic properties. The best current approach to prepare a targeted zeolite still relies on trial and error's synthetic procedures since a rational understanding of the impact of synthesis variables on the final structures is still missing. To discern the role of a variety of organic templates, we perform simulations of the early stages of condensation of silica oligomers by combining DFT, Brønsted-Evans-Polanyi relationships and kinetic Monte Carlo simulations. We investigate an extended reaction path mechanism including 258 equilibrium reactions and 242 chemical species up to silica octamers, comparing the computed concentrations of Si oligomers with <sup>29</sup> SI NMR experimental data. The effect of the templating agent is linked to the modification of the intramolecular H-bond network in the growing oligomer, which produces higher concentration of 4-membered ring intermediates, precursors of the key double-four ring building blocks present on more than 39 known zeolite topologies.
New Aspects of the Ring-Opening Polymerization of Cycloolefins (1985)

Abstract The reaction of cycloolefins with the components of the catalytic system WCl6/epichlorohydrin/Al(iBu)3, active in the ring-opening polymerization of cycloolefins, was investigated in order to get additional information on the mechanism of polymerization. The study led to the following conclusions. 1) Olefin complexation with the transition metal has a decisive influence on active center formation. 2) Trivalent tungsten species resulting from fast reduction of the cycloolef in/transition metal complex by aluminum alkyl or from a slow reduction process d W(VI) in the presence of cycloolef in alone, show a particularly high activity in ring-opening polymerization. 3) In the case of tricomponent systems (e.g., WCl6/Al(iBu)3/ epichlorohydrin or WCl6/Al(iBu)3/chloranil), the nature of the third component has a decisive effect on both polymerization kinetics and the molecular weight and structure of the resulting polymer. The data are discussed in the context of a reaction mechanism based on carbene complexes as active centers.
All your clouds are belong to us (2011)

Cloud Computing resources are handled through control interfaces. It is through these interfaces that the new machine images can be added, existing ones can be modified, and instances can be started or ceased. Effectively, a successful attack on a Cloud control interface grants the attacker a complete power over the victim's account, with all the stored data included.
Component-based system for designing power supply of no expert knowledge required (2006)

This paper introduces the Component based architecture (CBA) employed in a software to design the switching mode power supply (SMPS). Theoretically, there is a unique mapping between a real converter and its behavior. Based on a known circuit topology, the proper design is underlining in the combination of components and its physical configuration. Neither abstract electrical model nor domain knowledge is expected from the user. Besides, this architecture turns optimizing the abstract parameters into component selection.
A study on collagen orientation by permanent magnets (2006)

In this study, a simple magnetic circuit for the collagen orientation using permanent magnets was developed.
Joint orientation and position estimation from differential RSS measurements at on-body nodes (2016)

In the specific context of wearable wireless networks, this work aims at improving the accuracy and the robustness of radiolocation solutions based on standard narrow-band radio technologies for user-centric mobile applications. The proposed solution takes benefits from off-body or body-to-body radio links, with respect to fixed elements of infrastructure or to other mobile equipped subjects, respectively. The main idea is to infer relative angular information between the carrying body's heading and the median direction of arrival of received signals. For this sake, we rely on differential received power measurements issued at judiciously placed on-body nodes. Light calibration procedures (e.g., based on the full-scale dynamics of observed measurements) and joint absolute position/orientation estimation algorithms then enable to cover both individual/non-cooperative and collective/cooperative navigation needs. The performance is assessed by means of field experiments with IEEE 802.15.4-compliant integrated devices operating at 2.4 GHz and an optical motion capture system delivering the ground truth reference. On this occasion, our proposal is shown to be resilient against mobile Non-line of Sight (NLoS) situations (e.g., in crowded environments).
Adaptive Pixel Mass Recalibration for Mass Spectrometry Imaging Based on Locally Endogenous Biological Signals (2021)

Mass spectrometry imaging (MSI) is a powerful and convenient method for revealing the spatial chemical composition of different biological samples. Molecular annotation of the detected signals is only possible if a high mass accuracy is maintained over the entire image and the <i>m</i>/<i>z</i> range. However, the change in the number of ions from pixel-to-pixel of the biological samples could lead to small fluctuations in the detected <i>m</i>/<i>z</i>-values, called mass shift. The use of internal calibration is known to offer the best solution to avoid, or at least to reduce, mass shifts. Their "a priori" selection for a global MSI acquisition is prone to false positive detection and therefore to poor recalibration. To fill this gap, this work describes an algorithm that recalibrates each spectrum individually by estimating its mass shift with the help of a list of pixel-specific internal calibrating ions, automatically generated in a data-adaptive manner (https://github.com/LaRoccaRaphael/MSI_recalibration). Through a practical example, we applied the methodology to a zebrafish whole-body section acquired at a high mass resolution to demonstrate the impact of mass shift on data analysis and the capability of our algorithm to recalibrate MSI data. In addition, we illustrate the broad applicability of the method by recalibrating 31 different public MSI data sets from METASPACE from various samples and types of MSI and show that our recalibration significantly increases the numbers of METASPACE annotations (gaining from 20 up to 400 additional annotations), particularly the high-confidence annotations with a low false discovery rate.
Interview: HIV-1 Proviral DNA Excision Using an Evolved Recombinase (2008)

HIV-1 integrates into the host chromosome of infected cells and persists as a provirus flanked by long terminal repeats. Current treatment strategies primarily target virus enzymes or virus-cell fusion, suppressing the viral life cycle without eradicating the infection. Since the integrated provirus is not targeted by these approaches, new resistant strains of HIV-1 may emerge. Here, we report that the engineered recombinase Tre (see Molecular evolution of the Tre recombinase , Buchholz, F., Max Planck Institute for Cell Biology and Genetics, Dresden) efficiently excises integrated HIV-1 proviral DNA from the genome of infected cells. We produced loxLTR containing viral pseudotypes and infected HeLa cells to examine whether Tre recombinase can excise the provirus from the genome of HIV-1 infected human cells. A virus particle-releasing cell line was cloned and transfected with a plasmid expressing Tre or with a parental control vector. Recombinase activity and virus production were monitored. All assays demonstrated the efficient deletion of the provirus from infected cells without visible cytotoxic effects. These results serve as proof of principle that it is possible to evolve a recombinase to specifically target an HIV-1 LTR and that this recombinase is capable of excising the HIV-1 provirus from the genome of HIV-1-infected human cells. Before an engineered recombinase could enter the therapeutic arena, however, significant obstacles need to be overcome. Among the most critical issues, that we face, are an efficient and safe delivery to targeted cells and the absence of side effects.
A high-affinity human PD-1/PD-L2 complex informs avenues for small-molecule immune checkpoint drug discovery (2019)

Abstract Immune checkpoint blockade of programmed death-1 (PD-1) by monoclonal antibody drugs has delivered breakthroughs in the treatment of cancer. Nonetheless, small-molecule PD-1 inhibitors could lead to increases in treatment efficacy, safety, and global access. While the ligand-binding surface of apo-PD-1 is relatively flat, it harbors a striking pocket in the murine PD-1/PD-L2 structure. An analogous pocket in human PD-1 may serve as a small-molecule drug target, but the structure of the human complex is unknown. Because the CC′ and FG loops in murine PD-1 adopt new conformations upon binding PD-L2, we hypothesized that mutations in these two loops could be coupled to pocket formation and alter PD-1’s affinity for PD-L2. Here, we conducted deep mutational scanning in these loops and used yeast surface display to select for enhanced PD-L2 binding. A PD-1 variant with three substitutions binds PD-L2 with an affinity two orders of magnitude higher than that of the wild-type protein, permitting crystallization of the complex. We determined the X-ray crystal structures of the human triple-mutant PD-1/PD-L2 complex and the apo triple-mutant PD-1 variant at 2.0 Å and 1.2 Å resolution, respectively. Binding of PD-L2 is accompanied by formation of a prominent pocket in human PD-1, as well as substantial conformational changes in the CC′ and FG loops. The structure of the apo triple-mutant PD-1 shows that the CC′ loop adopts the ligand-bound conformation, providing support for allostery between the loop and pocket. This human PD-1/PD-L2 structure provide critical insights for the design and discovery of small-molecule PD-1 inhibitors. Significance Statement Immune checkpoint blockade of programmed death-1 (PD-1) by monoclonal antibody drugs has transformed the treatment of cancer. Small-molecule PD-1 drugs have the potential to offer increased efficacy, safety, and global access. Despite substantial efforts such small-molecule drugs have been out of reach. We identify a prominent pocket on the ligand-binding surface of human PD-1 that appears to be an attractive small-molecule drug target. The pocket forms when PD-1 is bound to one of its ligands, PD-L2. Our high-resolution crystal structure of the human PD-1/PD-L2 complex facilitates virtual drug-screening efforts and opens additional avenues for the design and discovery of small-molecule PD-1 inhibitors. Our work provides a strategy that may enable discovery of small-molecule inhibitors of other “undruggable” protein-protein interactions.
Effects of Heat and Fermentation on the Extractability of Minerals from Soybean Meal and Corn Meal Blends (1984)

ABSTRACT Autoclaving (121°C for 30 min) soybean meal reduced phytate phosphorus by 17.5%; phosphorus soluble in 0.03N HCl decreased 27.1%, and iron decreased 17.2%. Heat treatment increased (P &lt; 0.05) extractability of zinc and potassium (soluble in 0.03N HCl) in soybean meal. A natural lactic acid fermentation of corn meal decreased phytate phosphorus by 77.8% and increased phosphorus soluble in 0.03N HCl by 37.9%. Phosphorus and iron from corn meal soluble in 0.03N HCl decreased in quantity when soybean meal was added. There was little difference in the % magnesium, zinc and potassium soluble in 0.03N HCl whether in corn meal or corn meal‐soybean meal blends.
Metronidazole susceptibility testing for Helicobacter pylori: comparison of disk, broth, and agar dilution methods and their clinical relevance (1993)

Since the methods for metronidazole susceptibility testing of Helicobacter pylori have not been standardized or validated, we compared three methods that are used to test the metronidazole susceptibilities of 25 isolates of H. pylori. Specifically, we examined the methods of Steer's replicator agar dilution, tube broth microdilution, and modified Kirby-Bauer disk diffusion. The metronidazole disk zone sizes obtained by the disk diffusion method correlated well (r = 0.74) with the MICs obtained by the agar dilution method. Afterward, the disk diffusion method was used to characterize the metronidazole susceptibilities of 44 isolates of H. pylori. Dual therapy (bismuth and metronidazole) proved to be highly effective against metronidazole-susceptible strains (81.6% eradication rate) but fared poorly against resistant strains (16.7% eradication rate; P < 0.01). Using agar dilution testing, we validated the modified Kirby-Bauer disk diffusion method for metronidazole susceptibility testing of H. pylori and conclude that it is practical, accurate, and clinically applicable.
Integrating spatial sensing to an interactive mobile 3D map (2012)

We present an interaction technique that integrates spatial sensing to an interactive 3D city model in order to support efficient localization of objects (esp. buildings) known or remembered in the real world. The technique offers a unified 3D interaction scheme for both visible and remote objects. In the egocentric view, sensor data from the mobile device (accelometer, gyroscope, GPS) is utilized to couple the viewport to user's movement similarly as in mobile AR. The technique offers easy shifting from the viewport-coupled mode to a top-down view where movement is POI-based. A field experiment compared it to an exocentric technique resembling the traditional pan-and-zoom in 2D mobile maps. The two techniques showed differential benefits for target acquisition performance.
ChemInform Abstract: POLAR EFFECTS OF 4‐SUBSTITUENTS IN THE SOLVOLYSIS OF TETRACYCLO(6.2.1.13,6.02,7)DODECAN‐11‐YL TRIFLATES. THROUGH‐SPACE VS. INDUCTIVE MODEL (1985)

Abstract Für die Solvolysereaktionen der Triflate (I) im stark nucleophilen, mittelmäßig ionisierenden, 60proz. wäßrigen Aceton ergeben sich bei 75°C Geschwindigkeitskonstanten von 8.3·10 ‐3 ‐1.9·10 ‐2 /s und für die Reaktion im wenig nucleophilen, stark ionisierenden Hexafluorisopropanol 5.9·10 ‐5 ‐1,8·10 ‐2 /s bei 25°C mit Aktivierungsenthalpien und ‐entropien von 18.2‐23.5 und 10.0‐20.5 kcal/mol bzw. ‐19 bis +0.8 und ‐17.5 bis ‐6.7 cal/mol·Grad.
GO Hessian for Expectation-Based Objectives (2021)

An unbiased low-variance gradient estimator, termed GO gradient, was proposed recently for expectation-based objectives E_q_γ(y) [f(y)], where the random variable (RV) y may be drawn from a stochastic computation graph (SCG) with continuous (non-reparameterizable) internal nodes and continuous/discrete leaves. Based on the GO gradient, we present for E_q_γ(y) [f(y)] an unbiased low-variance Hessian estimator, named GO Hessian, which contains the deterministic Hessian as a special case. Considering practical implementation, we reveal that the GO Hessian in expectation obeys the chain rule and is therefore easy-to-use with auto-differentiation and Hessian-vector products, enabling efficient cheap exploitation of curvature information over deep SCGs. As representative examples, we present the GO Hessian for non-reparameterizable gamma and negative binomial RVs/nodes. Leveraging the GO Hessian, we develop a new second-order method for E_q_γ(y) [f(y)], with challenging experiments conducted to verify its effectiveness and efficiency.