Why Should Internists Be Interested in Interleukin-1? (1988)

Editorials1 July 1988Why Should Internists Be Interested in Interleukin-1?Ruth Neta, PhD, Joost J. Oppenheim, MDRuth Neta, PhDSearch for more papers by this author, Joost J. Oppenheim, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-109-1-1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptInterleukin-1 is a hormone-like polypeptide produced in response to infection, injury, physiologic stress, or antigenic challenge. Originally named for its ability to act as an intercellular signal between leukocytes, interleukin-1 has pleiotropic effects on tissues and organs (1). Fever, elevation of acute-phase reactive proteins, and neutrophilia are some responses to systemic interleukin-1 that make it a key mediator of inflammation (2). As an inflammatory mediator, interleukin-1 may be both beneficial and harmful. Current studies focus on possible therapeutic uses of interleukin-1 itself, as well as its agonists and antagonists. Although the availability of large quantities of recombinant interleukin-1 has made...References1. OppenheimKovacsMatsushimaDurum JEKS. There is more than one interleukin 1. Immunol Today. 1986;7:45-56. CrossrefMedlineGoogle Scholar2. Dinarello C. Interleukin-1. Rev Infect Dis. 1984;6:51-95. CrossrefMedlineGoogle Scholar3. Lepe-ZunigaGery JI. Production of intracellular and extracellular interleukin-1 (IL-1) by human monocytes. Clin Immunol Immunopathol. 1984;31:222-30. CrossrefMedlineGoogle Scholar4. Dinarello C. Biology of interleukin 1. FASEB J. 1988;2:108-15. CrossrefMedlineGoogle Scholar5. DurumOppenheimNeta SJR. Immunophysiological role of interleukin-1. In: Oppenheim JJ, Shevach E, eds. Immunophysiology: Role of Cells and Cytokines in Immunity and Inflammation. Oxford University Press; 1988. In press. Google Scholar6. Besedovskydel ReySorkinDinarello HAEC. Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones. Science. 1986;233:652-4. CrossrefMedlineGoogle Scholar7. LeeTsouChan SAH. Glucocorticoids selectively inhibit the transcription of the interleukin 1 beta gene and decrease the stability of interleukin 1 beta mRNA. Proc Natl Acad Sci USA. 1988;85:1204-8. CrossrefMedlineGoogle Scholar8. AkahashiOppenheimMatsushima TJK. Induction of high affinity IL-1 receptor on human peripheral blood lymphocytes by glucocorticosteroid hormones. J Exp Med. 1988. In press. CrossrefGoogle Scholar9. MooreWarren MD. Synergy of interleukin-1 and granulocyte colony-stimulating factor: in vivo stimulation of stem-cell recovery and hematopoietic regeneration following 5-fluorouracil treatment of mice. Proc Natl Acad Sci USA. 1987;84:7134-8. CrossrefMedlineGoogle Scholar10. ZucaliDinarelloOblonGrossAndersonWeiner JCDMLR. Interleukin 1 stimulates fibroblasts to produce granulocytemacrophage colony-stimulating activity and prostaglandin E2. J Clin Invest. 1986;77:1857-63. CrossrefMedlineGoogle Scholar11. LibbyWarnerFriedman PSG. Interleukin-1: a mitogen for human vascular smooth muscle cells that induces the release of inhibitory prostanoids. J Clin Invest. 1988. In press. CrossrefMedlineGoogle Scholar12. MortensonShapiroLinDouchesNeta RJBSR. Interaction of recombinant interleukin-1 (IL-1) and recombinant tumor necrosis factor (TNF) in the induction of mouse acute phase proteins. J Immunol. 1988. In press. Google Scholar13. GhezziSaccardoVillaRossiBianchiDinarello PBPVMC. Role of interleukin-1 in the depression of liver drug metabolism by endotoxin. Infect Immun. 1986;54:837-40. CrossrefMedlineGoogle Scholar14. Dayerde RochemonteixBurrusDemczukDinarello JBBSC. Human recombinant interleukin 1 stimulates collagenase and prostaglandin E2 production by synovial cells. J Clin Invest. 1986;77:645-8. CrossrefMedlineGoogle Scholar15. MovatCybulskyColditzChanDinarello HMIMC. Acute inflammation in gram negative infection: endotoxin, interleukin-1, tumor necrosis factor, and neutrophils. Fed Proc. 1987;46:97-104. MedlineGoogle Scholar16. NakamuraNakataKashimotiYoshidaYamada SKSHM. Antitumor effect of recombinant human interleukin-1 alpha against murine syngeneic tumors. Jpn J Cancer Res. 1986;77:767-73. MedlineGoogle Scholar17. Van der MeerBarzaWolffDinarello JMSC. Low dose recombinant interleukin-1 protects granulocytopenic mice from lethal gram-negative infection. Proc Natl Acad Sci USA. 1988. In press. CrossrefMedlineGoogle Scholar18. NetaDouchesOppenheim RSJ. Interleukin 1 is a radioprotector. J Immunol. 1986;136:2483-8. MedlineGoogle Scholar19. Neta R. Cytokines in radioprotection and therapy of radiation injury. Biotherapy. 1988. In press. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. 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