gebhart/patrepeval huggingface dataset:
The coated wire electrode glucose sensor. (1988)

Previous techniques for sensing and measuring glucose are briefly reviewed and compared. The genesis of the glucose coated wire electrode lies in liquid membrane technology, and the basic principle of the electrode is described. The electrode utilizes a quaternary ammonium salt with a sparingly soluble metallic salt of glucose, in a matrix such as poly(vinyl chloride). Fabrication procedures are detailed. Typical sensor responses are illustrated with experimental data. The sensor generally shows a voltage that decreases linearly with increasing glucose concentration over approximately 40 mg/dl to 200 mg/dl. The time response of the sensor is of the order of seconds, and the lifetime observed to date is of the order of several months. Initial studies of mechanism are discussed, using liquid NMR. Preliminary interference effect studies to date are summarized, in which common compounds such as ascorbic acid, uric acid, L-cystine, glycine, and bilirubin were used. Singly these compounds show no significant interference effects.
Design of a multilinguistic Problem Based Learning learning environment in the metaverse (2010)

There is a growing interest in teaching people to acquire a global perspective. For this purpose, educational institutions are encouraging intercultural exchanges, such as short-term overseas study programs and internships. However, such programs are so expensive that students cannot take them easily. In this paper, we have built a multilinguistic learning environment in cyber-space. We have designed a learning environment that is optimal for Problem Based Learning (PBL). PBL allows intensive exchanges. Unlike ordinary PBL, this environment enables students to learn in a group consisting of students with diverse senses of value. Students can develop a new sense of value through exchanges with people with different cultural backgrounds, and the teacher can cultivate new perspectives in training students with diverse cultural backgrounds.
System Calls Instrumentation for Intrusion Detection in Embedded Mixed-Criticality Systems (2019)

System call relative information such as occurrences, type, parameters, and return values are well established metrics to reveal intrusions in a system software. Many Host Intrusion Detection Systems (HIDS) from research and industry analyze these data for continuous system monitoring at runtime. Despite a significant false alarm rate, this type of defense offers high detection precision for both known and zero-day attacks. Recent research focuses on HIDS deployment for desktop computers. Yet, the integration of such run-time monitoring solution in mixed-criticality embedded systems has not been discussed. Because of the cohabitation of potentially vulnerable non-critical software with critical software, securing mixed-criticality systems is a non trivial but essential issue. Thus, we propose a methodology to evaluate the impact of deploying system call instrumentation in such context. We analyze the impact in a concrete use-case with PikeOS real-time hypervisor.
On the phase behavior of blends of polymers and nematic liquid crystals (1998)

The phase behavior of mixtures of polymers and nematic liquid crystals (LC) is investigated. Two types of systems are examined. The first one deals with blends in which the polymer is made of linear chains. In this case, a systematic study of the effects of various parameters on the phase diagrams is performed. In particular, it is shown how increasing the polymer size and/or the LC molecule size increases the miscibility gap of the mixture. It also reduces the region where a single nematic phase is observed in the presence of a tiny amount of polymer. Likewise, the relative effects of the isotropic and the nematic interaction parameters on the phase diagrams are examined. The second part of this investigation deals with blends involving crosslinked polymers. Here, substantial differences are observed as compared to the case where the polymer components are made of linear chains. These differences are illustrated by showing the phase diagrams in similar conditions for both blends. Unlike the case of a linear polymer matrix, it is observed that the single nematic phase and the nematic-isotropic spinodal branches are absent from the phase diagram of crosslinked polymers. This results into significant distortions of the phase diagram. In order to highlight all these effects, examples representing hypothetical blends are considered. These examples are chosen for illustration of the results in which the choice of numerical parameters is made consistently with the existing values in the literature which makes comparison with published data possible.
MATURATION OF MACROPHAGES UNDER THE INFLUENCE OF MURAMYL PEPTIDES (2014)

Muramyl peptides from bacterial cell wall trigger the modifications in macrophages similar to maturation observed with dendritic cells. Mature macrophages reduced their capacity for phagocytosis, comparing with control, while the bactericidal activity increased. Phenotype analysis of human macrophages exposed to muramyl peptides showed the increasing expression of costimulatory receptors and antigen presenting molecules. On the other hand, there was downregulation of receptors involved in recognition and engulfing of microorganism. In response to bacterial component macrophages secreted several cytokines: IL–12, TNFα, IL–6. (Med. Immunol., 2005, vol.7, № 1, pp. 21526)
On the Choice and Number of Microarrays for Transcriptional Regulatory Network Inference (2010)

These results support utilization of neff as a potent descriptor of microarray compendia. In addition, they highlight a straightforward correlation-based method for TRNI with demonstrated meaningful statistical testing for significant edges, readily applicable to compendia from any species, even when a truth set is not available. This work facilitates a more refined approach to construction and utilization of mRNA expression compendia in TRNI.
Advanced Glycation Endproducts Induce Changes in Glucose Consumption, Lactate Production, and ATP Levels in SH-SY5Y Neuroblastoma Cells by a Redox-Sensitive Mechanism (2003)

Advanced glycation endproducts (AGEs) accumulate on long-lived proteins, including beta-amyloid plaques in Alzheimer's disease, and are suggested to contribute to neuronal dysfunction and cell death. We have investigated the effects of a model AGE upon glucose metabolism and energy production in a neuroblastoma cell line. AGEs decrease cellular ATP levels and increase glucose consumption and lactate production. All of the AGE-induced metabolic changes can be attenuated by antioxidants such as (R+)-alpha-lipoic acid and 17beta-estradiol. These antioxidants may become useful drugs against (AGE-mediated) effects in neurodegeneration through their positive effects on cellular energy metabolism.
An Overview of Parameter and Cost for Battery Electric Vehicles (2021)

The launch of both battery electric vehicles (BEVs) and autonomous vehicles (AVs) on the global market has triggered ongoing radical changes in the automotive sector. On the one hand, the new characteristics of the BEV powertrain compared to the combustion type have resulted in new central parameters, such as vehicle range, which then become an important selling point. On the other hand, electric components are as yet not optimized and the sensors needed for autonomous driving are still expensive, which introduces changes to the vehicle cost structure. This transformation is not limited to the vehicle itself but also extends to its mobility and the necessary infrastructure. The former is shaped by new user behaviors and scenarios. The latter is impacted by the BEV powertrain, which requires a charging and energy supply infrastructure. To enable manufacturers and researchers to develop and optimize BEVs and AVs, it is necessary to first identify the relevant parameters and costs. To this end, we have conducted an extensive literature review. The result is a complete overview of the relevant parameters and costs, divided into the categories of vehicle, infrastructure, mobility, and energy.
Spontaneous interbilayer transfer of phospholipids: Dependence of acyl chain composition (1993)

The diffusion-mediated intervesicle transfer of a variety of fluorescent N-(S-bimanylmercaptosuccinyl)phosphatidylethanolamines (BMS-PEs), and of a more limited series of radiolabeled phosphatidylcholines (PCs), has been investigated as a function of the acyl chain composition of the labeled molecules and the composition of the lipid vesicles. Increasing the total acyl chain length of a BMS-PE by two methylene residues increases the free energy of activation for probe desorption from a lipid bilayer (delta Gd not equal to) by ca. 1300 cal mol-1, while the addition of one double bond to either chain decreases delta Gd not equal to by a slightly smaller increment. The values of these increments in delta Gd not equal to are surprisingly consistent with variations in BMS-PE acyl chain length, positional isomerism (for heteroacyl BMS-PEs), and the sterol content or degree of acyl chain saturation of the lipid bilayer. However, the successive addition of multiple cis double bonds to the same acyl chain leads to progressively smaller decrements in the value of delta Gd not equal to. Radiolabeled PCs show somewhat lower absolute rates of interbilayer transfer than the corresponding BMS-PEs, but the incremental contributions of added methylene groups or cis double bonds to delta Gd not equal to are essentially identical for the two classes of lipids, validating the use of BMS-PEs as representative probes of phospholipid behavior for these experiments. Our data suggest that the relative rates of spontaneous transfer of a variety of phospholipids from bilayer membranes can be predicted to good approximation from a few basic features of the phospholipid structure.(ABSTRACT TRUNCATED AT 250 WORDS)
NEAR INFRARED-RESPONSIVE HYDROGELS FOR THE SPATIOTEMPORAL CONTROL OF BONE MORPHOGENETIC PROTEIN 2 BIOAVAILABILITY IN CRITICAL-SIZED BONE DEFECTS (2018)

There is a growing interest in the development of tissue engineering (TE) therapies to repair damaged bone. Among the scaffolds for TE applications, injectable hydrogels have demonstrated great pot...
Approaching a human-centred internet of things (2013)

This paper surveys recent Internet of Things (IoT) related HCI literature, and examines it in light of a comprehensive framework by Atzori et al. (2010). Mapping HCI literature to this framework helped us understand the extent and the focus of IoT related HCI efforts, including a lack of HCI engagement with deeper human-centred perspectives of the IoT. It also revealed HCI considerations for the IoT which we added to the framework. This extended the framework to a tool for an HCI audience that can be used for 'thinking through' the design of IoT technologies. We close the paper by demonstrating how this tool has been found useful in an IoT research project and at the same time illustrating our approach in how to engage more deeply with human-centred concerns.
Hypoxia and tumor-associated macrophages (2014)

Tumor-associated macrophages (TAMs) provide a significant contribution to tumor growth and metastasis. We demonstrated the existence of two main TAM subsets, differing in activation state and localization. Of these, M2-like TAMs reside in hypoxic regions of the tumor mass and can be used as targets for hypoxia tracers. This said, hypoxia does not regulate the differentiation of TAMs but finely tunes the activity of the M2-like population.
Roadmap for precision preclinical x-ray radiation studies (2022)

This Roadmap paper covers the field of precision preclinical x-ray radiation studies in animal models. It is mostly focused on models for cancer and normal tissue response to radiation, but also discusses other disease models. The recent technological evolution in imaging, irradiation, dosimetry and monitoring that have empowered these kinds of studies is discussed, and many developments in the near future are outlined. Finally, clinical translation and reverse translation are discussed.
Assignments / Homework (2005)

Any of the problems in Section 10 could be used for homework assignments. Some are difficult enough that they are better suited for homework, when students have more time to think about them and are under less stress.
HAEMODYNAMIC CHANGES IN ACTH‐INDUCED HYPERTENSION IN SHEEP (1980)

1. ACTH (20 microgram/kg per day) produced an elevation in blood pressure associated with an increase in cardiac output in conscious sheep, due in the first 72 h to a rise in heart rate. Stroke volume did not rise until the fourth day of ACTH treatment. 2. Calculated total peripheral resistance did not change. 3. Intreavenous administration of acebutolol prior to and during ACTH administration did not modify the rise in blood pressure, but this was associated with a rise in total peripheral resistance. 4. These studies show that while ACTH-induced hypertension is usually associated with increased cardiac output, rather than total peripheral resistance it still occurs, but is associated with a rise in total peripheral resistance if the rise in cardiac output is prevented by beta-adrenoreceptor blockade.
Beam focusing antenna array technology for non-stationary mobility (2016)

The aim of this paper <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">a</sup> is to study new antenna array technologies in order to manage efficiently heterogeneous, fixed and mobile traffic. Traffic light close to the cell edge is introduced to generate non stationary mobility pattern in the cell. A car following model is used to model the mobility behavior of the vehicles. A heterogeneous antenna system with different large antenna array technologies is considered: Virtual Small Cell (VSC), virtual small cell with Self-Organizing Network (VSC-SON) and beamforming with multilevel global codebook that manages the heterogeneous antenna system at the Base Station (BS). The first two technologies improve the cell performance due to the capability to focus the signal at the traffic concentration near the traffic light. The novel beamforming solution with global codebook can further and significantly improve performance due to the capability to focus the signal along the road and to implicitly balance the traffic between the different antennas. Numerical simulations illustrate the benefits brought about by the different antenna technologies.
Immunocytochemical localization of mitochondrial proteins in the rat hepatocyte. (1982)

Two mitochondrial proteins, carbamyl phosphate synthetase (CPS) and a structural membrane protein, OMM-35, were specifically localized in the hepatocyte mitochondrial matrix and inner and outer membranes, respectively, using the protein A-gold technique. Three embedding media, Epon, glycol methacrylate (GMA), and Lowicryl K4M, were tested for their ability to provide good ultrastructural preservation of mitochondrial membranes, while at the same time retaining protein antigenicity in embedded liver. Epon embedding proved to be relatively unsuitable, since mitochondrial membranes were poorly preserved. GMA and Lowicryl however gave excellent ultrastructural preservation and retained protein antigenicity sufficiently well to enable the localization of the structural membrane protein. Both qualitative and quantitative immunocytochemical demonstration of CPS have ascertained its localization to the rat hepatocyte mitochondrial matrix. The enzyme was undetectable, however, in the mitochondria of liver endothelial cells. OMM-35 was specifically located in the mitochondrial membranes and the quantitative evaluation confirms the biochemical data that OMM-35 is clearly enriched in the outer mitochondrial membrane. OMM-35 was detected in mitochondria of both hepatocytes and endothelial cells. The labeling of a relatively minor structural membrane protein such as OMM-35 gives and indication of the high sensitivity of the protein A-gold immunocytochemical technique.
Cophosphorylation of amphiphysin I and dynamin I by Cdk5 regulates clathrin-mediated endocytosis of synaptic vesicles (2003)

It has been thought that clathrin-mediated endocytosis is regulated by phosphorylation and dephosphorylation of many endocytic proteins, including amphiphysin I and dynamin I. Here, we show that Cdk5/p35-dependent cophosphorylation of amphiphysin I and dynamin I plays a critical role in such processes. Cdk5 inhibitors enhanced the electric stimulation-induced endocytosis in hippocampal neurons, and the endocytosis was also enhanced in the neurons of p35-deficient mice. Cdk5 phosphorylated the proline-rich domain of both amphiphysin I and dynamin I in vitro and in vivo. Cdk5-dependent phosphorylation of amphiphysin I inhibited the association with beta-adaptin. Furthermore, the phosphorylation of dynamin I blocked its binding to amphiphysin I. The phosphorylation of each protein reduced the copolymerization into a ring formation in a cell-free system. Moreover, the phosphorylation of both proteins completely disrupted the copolymerization into a ring formation. Finally, phosphorylation of both proteins was undetectable in p35-deficient mice.
Oral immunization with recombinant enterovirus 71 VP1 formulated with chitosan protects mice against lethal challenge (2014)

These data indicated that oral immunization with rVP1 in formulation with chitosan was effective in inducing broad-spectrum immune responses and might be a promising subunit vaccine candidate for preventing EV71 infection.
Allelic diversity in a novel gene pool of canola-quality Brassica napus enriched with alleles from B. rapa and B. carinata (2010)

Brassica napus is an amphidiploid with genome AACC and is relatively deficient in genetic diversity. The abundant genetic diversity in other A- and C-genome Brassica species is a valuable resource to expand the narrow gene pool of B. napus. Recently the Ar genomic components from Chinese B. rapa (ArAr) and Cc genomic components from Ethiopian mustard B. carinata (BBCcCc) were introgressed into B. napus through interspecific hybridisation, and the Ar/Cc components were enriched through two generations of molecular marker-assisted selection. In this study, the simple sequence repeat (SSR) allelic diversity of 29 of these new-type B. napus lines, 12 from the first generation and 17 from the second generation, was compared with 66 international B. napus varieties from Australia, China and other countries. Hierarchical clustering and two-dimensional multidimensional scaling revealed that second generation lines and a few first generation lines, all selected for high Ar/Cc components, formed a unique population that was distantly separated from international B. napus. This novel gene pool had significantly higher richness of private SSR alleles and more alleles per SSR marker than the international B. napus varieties. The new-type B. napus lines showed variation in agronomic traits beyond the canola-quality B. napus parent. Many of the lines had low erucic acid and low glucosinolates in the seed (canola quality), indicating that they could be utilised immediately in canola breeding programs.
OXIDATIVE STRESS AND ENDOTHELIAL DYSFUNCTION IN ATHLETES AS A RISK FACTOR FOR CARDIOMYOPATHY OVERSTRAIN (2019)

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Multi-Sensor Multi-Target Data Association Algorithm Based on Swarm Intelligence (2013)

An swarm intelligence algorithm, particle swarm optimization (PSO) algorithm, is used in data association problem for multi-sensor multi-target data association. The association relation between measurements and targets is described by the likelihood function of filter innovation to establish the model of the optimal combination. Lagrange relaxation technology is used to reduce the combination to two dimensions firstly when solving the optimal combination problem, and then the improved PSO algorithm, which based on the cross and mutation rules, is used to obtain the optimal solution, and get the optimal association pairs for measurements and targets. The simulation shows the superiority of the method in accuracy and speed at last.
Pharmacology of acid suppression in the hospital setting: Focus on proton pump inhibition (2002)

The more potent and longer-lasting inhibition of gastric acid secretion provided by proton pump inhibitors (PPIs) as compared with histamine-2-receptor antagonists is caused in large part by differences in their mechanism of action. PPIs block histamine-2-, gastrin-, and cholinergic-mediated sources of acid production and inhibit gastric secretion at the final common pathway of the H+/K+ adenosine triphosphatase proton pump. In contrast, histamine-2-receptor antagonists cannot block receptor sites other than those mediated by histamine. It seems that the rapid loss of acid suppression activity by the histamine-2-receptor antagonists may be attributed to tolerance. Such tolerance has not occurred in patients receiving PPIs because these agents are irreversible inhibitors of the H+/K+ adenosine triphosphatase proton pump. For these reasons, patients who have acid-related disorders that require high levels of acid suppression do not respond well to intravenous histamine-2-receptor antagonists and would be excellent candidates for intravenous PPI therapy. Candidates for intravenous PPIs also include patients who cannot receive oral PPIs and those who may need the higher acid suppression therapy provided by the intravenous rather than the oral route. Clinical studies have demonstrated the efficacy of intravenous pantoprazole in maintaining adequate control of gastric acid output during the switch from oral to intravenous therapy in patients with severe gastroesophageal reflux disease or the Zollinger-Ellison syndrome. Intragastric administration of solutions prepared from oral PPIs has been used as an alternative to the intravenous route in critical care settings. However, decreased bioavailability may limit the value of intragastric delivery of PPIs because of the high frequency of gastric emptying problems in critically ill patients.
La contribution nancéienne à la constitution du corps enseignant de l’École supérieure de pharmacie de Strasbourg en 1919 et 1920 (2017)

Labrude Pierre. La contribution nancéienne à la constitution du corps enseignant de l’École supérieure de pharmacie de Strasbourg en 1919 et 1920. In: Revue d'histoire de la pharmacie, 104e année, N. 394, 2017. pp. 227-244.
Assessing the potential of photosensitizing flavoproteins as tags for correlative microscopy (2016)

Photosensitizing flavoproteins have great potential as tags for correlative light and electron microscopy (CLEM). We examine the photostability of miniSOG mutants and their ability to photo-oxidize diaminobenzidine, both key aspects for CLEM. Our experiments reveal a complex relation between these parameters and the production of different reactive oxygen species.
[Comparative study of the interoceptive effects of afobazole and diazepam]. (2010)

Interoceptive effects of afobazole (20 mg/kg, i.p.) and diazepam (0.5 and 5.0 mg/kg, i.p.) have been investigated using operant drug discrimination (DD) and passive avoidance "step through" state dependent dissociative learning (DL) paradigms in male autobred rats. It is established that afobazole in contrast to classical anxiolytics (diazepam) does not produce the state dependence (DL and DD). In substitution tests, afobazole (20 mg/kg, i.p.) caused saline level responding in diazepam-trained rats and did not influence the general profile of interoceptive diazepam stimulus. The data suggest the absence of overlap in receptor mechanisms of the interoceptive effects of afobazole and diazepam and low probability of drug dependence development after long-term (clinical) afobazole treatment.