gebhart/patrepeval huggingface dataset:
Multi-Sensor Scheduling for State Estimation with Event-Based, Stochastic Triggers (2015)

In networked systems, state estimation is hampered by communication limits. Past approaches, which consider scheduling sensors through deterministic event-triggers, reduce communication and maintain estimation quality. However, these approaches destroy the Gaussian property of the state, making it computationally intractable to obtain an exact minimum mean squared error estimate. We propose a stochastic event-triggered sensor schedule for state estimation which preserves the Gaussianity of the system, extending previous results from the single-sensor to the multi-sensor case.
Comprehensive sequence analysis of the 182 predicted open reading frames of yeast chromosome III (1992)

With the completion of the first phase of the European yeast genome sequencing project, the complete DNA sequence of chromosome III of Saccharomyces cerevisiae has become available (Oliver, S. G., et al., 1992, Nature 357, 38-46). We have tested the predictive power of computer sequence analysis of the 176 probable protein products of this chromosome, after exclusion of six problem cases. When the results of database similarity searches are pooled with prior knowledge, a likely function can be assigned to 42% of the proteins, and a predicted three-dimensional structure to a third of these (14% of the total). The function of the remaining 58% remains to be determined. Of these, about one-third have one or more probable transmembrane segments. Among the most interesting proteins with predicted functions are a new member of the type X polymerase family, a transcription factor with an N-terminal DNA-binding domain related to GAL4, a "fork head" DNA-binding domain previously known only in Drosophila and in mammals, and a putative methyltransferase. Our analysis increased the number of known significant sequence similarities on chromosome III by 13, to now 67. Although the near 40% success rate of identifying unknown protein function by sequence analysis is surprisingly high, the information gap between known protein sequences and unknown function is expected to widen and become a major bottleneck of genome projects in the near future. Based on the experience gained in this test study, we suggest that the development of an automated computer workbench for protein sequence analysis must be an important item in genome projects.
MC Simulation of Strained-Si MOSFET With Full-Band Structure and Quantum Correction (2004)

A new two-dimensional full-band Monte Carlo simulator, "Monte Carlo University of Texas" (MCUT) is introduced and described in this paper. MCUT combines some of the best features of semiclassical MC device simulation including full-band structure and flexibility of scattering processes, with generality of material composition and the ability to address degeneracy breaking among energy valleys and the associated effects on scattering and transport due to quantum confinement and strain effects. The latter capability derives from extension of a prior crystal-momentum-independent self-consistent Poisson-Schro/spl uml/dinger-based quantum corrected potential, to a valley dependent quantum correction via, in part, a new modeling concept of "effective strain" within the full-band structure code. Low field mobility simulation results for large tensile strained-Si channel nMOSFETs and unstrained-Si channel nMOSFETs device are compared with other simulation methods and experimental data to demonstrate the effectiveness of the approach, and the abilities to simulate high-field transport and transport in devices of a few 10s of nanometer channel lengths are briefly demonstrated.
Mapping of Amino Acid Residues in the p34 Subunit of Human Single-stranded DNA-binding Protein Phosphorylated by DNA-dependent Protein Kinase and Cdc2 Kinase in Vitro (1997)

Human single-stranded DNA-binding protein (HSSB, also called RPA), is a heterotrimeric complex that consists of three subunits, p70, p34, and p11. HSSB is essential for the in vitro replication of SV40 DNA and nucleotide excision repair. It also has important functions in other DNA transactions, including DNA recombination, transcription, and double-stranded DNA break repair. The p34 subunit of HSSB is phosphorylated in a cell cycle-dependent manner. Both Cdc2 kinase and the DNA-dependent protein kinase (DNA-PK) phosphorylate HSSB-p34 in vitro. In this study, we show that efficient phosphorylation of HSSB-p34 by DNA-PK requires Ku as well as DNA. The DNA-PK phosphorylation sites in HSSB-p34 have been mapped at Thr-21 and Ser-33. Kinetic studies demonstrated that a phosphate residue is first incorporated at Thr-21 followed by the incorporation of a second phosphate residue at Ser-33. We also identified Ser-29 as the major Cdc2 kinase phosphorylation site in the p34 subunit.
Interleukin 10 treatment of patients with rheumatoid arthritis enhances Fc gamma receptor expression on monocytes and responsiveness to immune complex stimulation. (2003)

These findings indicate that upregulation of Fc gamma R expression in RA with IL-10 treatment may counteract the otherwise antiinflammatory effects of IL-10 by potentiating immune complex mediated proinflammatory responses.
Medullasin enhances human natural killer cell activity. (1982)

Medullasin, a new serine protease found in bone marrow cells, increased markedly human natural killer cell activity. Whereas the natural killer cell activity measured immediately after the treatment with medullasin remained almost on the same level as the control, an incubation at 37 degrees C for several hours increased markedly the natural killer cell activity of the lymphocytes treated with medullasin. Enhancement of the natural cytotoxicity was caused by the treatment with physiologic concentrations of the protease (5-20 micrograms/ml). Inhibitors of medullasin such as phenylmethylsulfonyl fluoride and elastatinal prevented the activation of natural cytotoxicity. Depletion of lymphocytes bearing Fc receptors for IgG abolished the enhancement of natural killer cell activity by medullasin. Interferon activity was not detected in the supernatant of lymphocyte cultures stimulated with medullasin. The medullasin enhanced further the natural killer cell activity of lymphocytes stimulated with interferon. Medullasin activity was detected neither in unstimulated nor stimulated (by concanavalin A or phytohemagglutinin) human lymphocytes. The protease was released easily from human mature granulocytes into culture medium. It is considered from these results that the level of human natural killer cell activity is regulated by medullasin released by mature granulocytes.
Determination of Mebudipine in Human Plasma by Liquid Chromatography-tandem Mass Spectrometry. (2015)

In previous studies, mebudipine, a dihydropyridine calcium channel blocker, showed a considerable potential to be used in cardiovascular diseases. The aim of the current study was to develop a valid method using reversed-phase high performance liquid chromatography coupled with electrospray ionization mass spectrometry to assay mebudipine in the human plasma. Separation was achieved on a Zorbax Eclipse(®) C18 analytical column using a mobile phase consisted of methanol/water (90:10, v/v). The flow rate was 0.6 mL/min and carbamazepine was used as an internal standard (IS). This method involved the use of [M +Na](+) ions of mebudipine and IS at m/z 411 and 259, respectively with the selected ion monitoring (SIM) mode. There were no interfering peaks from endogenous components in blank plasma chromatograms. Standard curves were linear (r(2)>0.99) between 5 to 100 ng/mL. The mean extraction efficiency was about 84% and the limit of quantification for mebudipine was 5 ng/mL in plasma. The coefficient of variation and error at all of the intra-day and inter-day assessments were less than 11%. The results indicated that this method is a fast, accurate, sensitive, selective and reliable method for the determination of mebudipine in the human plasma. The assay method has been successfully used to estimate plasma concentration of mebudipine after the oral administration of 2.5 mg tablet in healthy adults.
Epigenetic randomness, complexity and singularity of human iris patterns (2001)

We investigated the randomness and uniqueness of human iris patterns by mathematically comparing 2.3 million different pairs of eye images. The phase structure of each iris pattern was extracted by demodulation with quadrature wavelets spanning several scales of analysis. The resulting distribution of phase sequence variation among different eyes was precisely binomial, revealing 244 independent degrees of freedom. This amount of statistical variability corresponds to an entropy (information density) of about 3.2 bits mm(-2) over the iris. It implies that the probability of two different irides agreeing by chance in more than 70% of their phase sequence is about one in 7 billion. We also compared images of genetically identical irides, from the left and right eyes of 324 persons, and from monozygotic twins. Their relative phase sequence variation generated the same statistical distribution as did unrelated eyes. This indicates that apart from overall form and colour, iris patterns are determined epigenetically by random events in the morphogenesis of this tissue. The resulting diversity, and the combinatorial complexity created by so many dimensions of random variation, mean that the failure of a simple test of statistical independence performed on iris patterns can serve as a reliable rapid basis for automatic personal identification.
Temporal induction of clusterin in cisplatin nephrotoxicity. (1997)

Clusterin is a ubiquitous glycoprotein induced in many organs, including the kidney, at times of tissue injury and/or remodeling. It is speculated in this study that clusterin preserves cell interactions that are otherwise perturbed by renal insults. The purpose of this study was to examine clusterin expression after cisplatin nephrotoxicity, a model characterized by a delayed time course of injury and a well-defined site of that injury (proximal tubule). Sprague-Dawley rats were treated with intravenous cisplatin (6 mg/kg) or vehicle. Serum creatinine concentrations were measured and kidneys harvested at 1, 2, and 5 days. Marked induction of clusterin mRNA was seen only at 5 days, a time when serum creatinine concentration was the highest. Histology of kidney tissue 5 days after cisplatin administration revealed marked tubular necrosis localized to the outer stripe of the outer medulla, a region rich in proximal tubules. Immunohistochemistry and in situ hybridization at 5 days demonstrated clusterin primarily in the inner stripe of the outer medulla. In conclusion, expression of clusterin follows renal injury with cisplatin at a time corresponding to the morphologic evidence of tubular necrosis and cell detachment; quite surprisingly, such expression occurs at a site distant from the primary injury.
Stimuli-Responsive Supramolecular Assembly Involving Cucurbit[8]uril and Porphyrin-based Tectons (2020)

International audience
[Calcitonin, gastrin, parathyroid hormone and the autonomic nervous system]. (1978)

Stimulation of the beta-adrenergic terminations was employed to determine whether calcitonin-secreting thyroid C cells are derived from the neural crest. Calcitonin secretion was increased, whereas parathormone, insulin and gastrin values were not significantly changed. In addition, administration of a beta-blocking drug before ethanol led to a marked fall in calcitonin with respect to the baseline. Once again, other hormone levels were not affected.
Effect of specific antibody pretreatment on liver uptake of 111In-labeled anticarcinoembryonic antigen monoclonal antibody in nude mice bearing human colon cancer xenografts. (1989)

Administration of a large dose (0.2 mg) of unlabeled specific anticarcinoembryonic antigen (anti-CEA) monoclonal antibody (MAB) to nude mice bearing LS174T human colon cancer xenografts significantly decreased normal liver uptake of 111In-labeled anti-CEA MAB (Indacea). Mice bearing tumors of approximately 1 g showed liver accumulation of indium-111 at 48 h following injection of 2 micrograms/10 microCi Indacea of 33.8 +/- 1.5% injected dose per gram (%ID/g) (N = 25). Treatment with 0.2 mg unlabeled anti-CEA MAB reduced this to 8.9 +/- 0.5% ID/g (N = 22; P less than 0.001). The dose of pretreatment was found to be critical. Increasing the amount of unlabeled MAB to 2.0 mg did not significantly improve the liver level of indium-111, but did compromise the tumor uptake of Indacea (15.9 +/- 1.3 versus 12.4 +/- 0.4% ID/g; P less than 0.05). Lowering the dose of pretreatment 10-fold resulted in increased (P less than 0.001) liver uptake of the label (26.5 +/- 2.8% ID/g). The unlabeled anti-CEA MAB treatment given as a single dose or fractionated over several days gave the same results. The decrease in liver uptake was the same for i.v. administration of the unlabeled MAB given 1 week prior to Indacea injection or mixed together with Indacea. With i.p. administration, simultaneous injection of the unlabeled MAB with Indacea was not as effective as pretreatment (20 min to 7 days) in decreasing the liver uptake of 111In (P less than 0.05). Epitope specificity and affinity were shown to be important considerations in the choice of MAB combinations used for pretreatment and imaging. Pretreatment with nonspecific MAB was ineffective in decreasing liver uptake of Indacea.
Enhancement of Quantum Dot Förster Resonance Energy Transfer within Paper Matrices and Application to Proteolytic Assays (2013)

Brightly luminescent semiconductor quantum dots (QDs) continue to play an increasing role in biophotonic research and applications such as bioassays. Here, we present methods for the immobilization of QDs on the cellulose fibers of paper substrates for Förster resonance energy transfer (FRET)-based assays of proteolytic activity. Steady-state and time-resolved fluorescence characterization of FRET between immobilized QDs and self-assembled dye-labeled peptides within the paper matrix revealed a substantial enhancement in energy transfer efficiency. Compared to bulk solution, the rate of energy transfer increased approximately fourfold resulting in a concomitant sevenfold increase in the ratio of FRET-sensitized acceptor dye emission and quenched QD emission. Spots of immobilized QDs with different amounts of dye-labeled peptide had bright luminescence under UV/violet illumination and the net QD and Alexa Fluor 555 (A555) dye emission was visible by eye as different colors. Tryptic digestion of the peptides linking the QD donor and the acceptor dyes resulted in loss of FRET. Changes in the dye/QD photoluminescence (PL) ratio permitted the tracking of proteolytic activity, including the effect of increasing amounts of aprotinin, a potent inhibitor of trypsin. The combination of QDs, a paper substrate, and enhanced FRET has strong potential for developing bioassays.
<title>Matrix representation for genetic algorithms</title> (1996)

Many problems have a structure with an inherently two (or higher) dimensional nature. Unfortunately, the classical method of representing problems when using Genetic Algorithms (GAs) is of a linear nature. We develop a genome representation with a related crossover mechanism which preserves spatial relationships for 2D problems. We then explore how crossover disruption rates relate to the spatial structure of the problem space. After discussing why a more appropriate representation is needed and exploring the theoretical aspects of our method, we empirically test our method to verify that it will be effective. We develop an easily understood abstracted class of problems with a 2D structure. A Monte Carlo study comparing the GAs using the string and matrix methods on a number of members of this problem class is then conducted. Results are presented which clearly show that for this particular problem, a matrix oriented GA should be used. Given our success in applying the matrix representation to an abstracted problem, we apply our methods to a real world image processing problem. We develop a method for using a GA with a matrix representation to denoise a greyscale image, and we apply this method to a noisy image. Finally, we discuss further ways in which to extend this work. Possible future image processing applications include various problems such as filter design, segmentation and edge detection. Other applications include semi-parametric density estimation, nonlinear multiple regression and solutions of multi-parameter multi-equation systems. We also discuss how problems where higher dimensional structures might be employed to further generalize our work to cases other than 2D problems.
Glutamate receptors are mobile at synaptic sites as revealed by single molecule fluorescence microscopy (2002)

International audience
Should we swear in front of our kids? (2015)

The other day, my toddler son came home from childcare saying poo. He is one of the younger children in his classroom and clearly he heard this phrase from an older child he admired. I couldn't help laughing at this unexpected outburst, which reinforced this behaviour thus cementing the phrase in his emerging vocabulary. Now he goes around muttering piss pissy poo under his breath as he goes about his business. Is this a bad thing? Should I scold him for using words he doesn't know the meaning of? Should I discourage him from using swear words and refrain from swearing in front of him?
PREDICTION OF CHLORIDE DIFFUSIVITY FROM THREE-DIMENSIONAL SPATIAL IMAGE OF CEMENT BASED MATERIALS (2010)

セメントペーストの反射電子像の画像解析から未水和セメント、水酸化カルシウム、粗大空隙の各相の自己相関関数を求め、セメントペーストの3次元イメージモデルの構築を行い、その3次元イメージモデルから塩化物イオンの拡散係数の推定を試みた。その結果、混和材を混入していないセメントペーストでは実測値に対し2分の1程度での推定を行うことができた。また、健全な試料の3次元イメージモデルからCa2＋の溶脱を考慮し人工劣化試料の塩化物イオンの拡散係数の推定を行った結果、人工劣化試料の実測値に対し同一オーダーでの推定を行うことができた。
Return loss characterization and analysis of high-speed serial interface (2016)

This paper describes the return loss characterization and analysis of a high-speed serial interface with T-coils at the transmitter and receiver. Today's high-speed links utilize equalization to mitigate channel loss and dispersion. In addition, T-coil networks are used at inputs and outputs to improve impedance matching and to enhance the receiver and transmitter bandwidth. To guarantee the transceiver performance, a wide range of Serializer Deserializer (SerDes) compliance specifications exist for the return loss measured at or near the package interface and the Printed Circuit Board (PCB). For multi-protocol SerDes, thus, T-coil networks are often necessary to meet the most stringent return loss specification. This paper presents the analysis and characterization of a high-speed transceiver with T-coils designed in a 28 nm CMOS process. Measurements are also presented to demonstrate the improvement in return loss and bandwidth of the transceiver.
Simocyclinones, Novel Cytostatic Angucyclinone Antibiotics Produced by Streptomyces antibioticus Tue 6040. II. Structure Elucidation and Biosynthesis. (2002)

The simocyclinones D4 (1) and D8 (2), members of a novel class of antibiotics, were isolated from the mycelial extract of Streptomyces antibioticus Tü 6040 and consist of angucyclinone, deoxysugar, octatetraene dicarboxylate and aminocoumarin structural elements. The structure elucidation was done by one and two dimensional NMR experiments, and other spectroscopic methods in combination with incorporation experiments using 13C labelled precursors.
Cation dysfunction associated with cerebral ischemia followed by reperfusion: a comparison of microdialysis and ion-selective electrode methods (2002)

Our results indicate that the flexible ISE is a reliable and accurate tool for monitoring ionic dysfunction that accompanies brain injury.
Design and implementation of Interoperable Medical Information System based on SOA (2009)

Interoperability among healthcare information systems is one of the most challenging problems in healthcare domain. In this paper, we propose a structure of interoperable medical information system based on SOA (service-oriented architecture) and Web 2.0 under the framework of regional health information network. Various components are described in detail, including authentication, data access, and services management and so on. Services for medical information getting are registered and published by the system; users then access the system to search and fetch demanded services and value-added applications. All of the heterogeneous and distributed data and applications are converted to independent services according to international standards. As a result of the use of SOA, the system is levels clearly demarcated with good universality and maintainability.
Differential Coexpression of Mex Efflux Pumps in a Clinical Strain of Metallo-β-lactamase-Producing Pseudomonas aeruginosa During the Stepwise Evolution of Resistance to Aminoglycosides (2010)

Background: We observed a stepwise evolution of resistance to aminoglycosides in Pseudomonas aeruginosa by tracking the development of multidrug resistance in a series of clinical isolates from a patient with a serious burn injury. Methods and Results: Fifteen isolates sequentially recovered from burn wounds fell into 4 groups (group 1 [G1], G2, G3, and G4) in the order of appearance in the evolution of resistance as assessed by antibiotic susceptibility profiles. In contrast to G1, which was sensitive to aminoglycosides, there was a stepwise evolution in resistance to aminoglycosides: gentamicin alone (G2), gentamicin and tobramycin (G3), and finally, amikacin (a panaminoglycoside/multidrug resistance; G4). All but the G1 strains were positive for metallo-β-lactamase and resistant to carbapenems and fluoroquinolones. When the isolates were screened for the expression of Mex efflux pumps by reverse transcriptase polymerase chain reaction, all 4 groups showed expression of the mexA but not mexC genes. The expression of mexE messenger RNA was observed in G2, G3, and G4, and that of mexX was observed in G4. The first isolates recovered for each of the 4 groups were further characterized as their representatives (G1-1, G2-1, G3-1, and G4-1) for the expression levels of Mex efflux pumps by a Western blotting analysis. In concomitance with the evolution of drug resistance, MexE protein was found to be differentially expressed. It was expressed in G2-1, up in G3-1 and back down in G4-1. The MexX protein was expressed only in G4-1 and may play a role in establishing amikacin resistance. Conclusions: These results suggest that a series of clinical isolates of a metallo-β-lactamase-producing P. aeruginosa has acquired panaminoglycoside-resistant profiles in a stepwise manner via differential coexpression of the Mex efflux pumps.