gebhart/patrepeval huggingface dataset:
From Database Programming to Business Process Programming (1995)

Over the past decade, database programming has focused on languages and methodologies for developing data-intensive applications, and on techniques for efficiently implementing them. Research in this area has yielded languages with rich type systems, orthogonal persistence, support for collection types, and other advanced features. The commercial impact of this research, however, has been rather limited. Database applications are a multi-billion dollar business worldwide, but most applications are still developed using rudimentary tools. The goal of this paper is to urge the database programming research community to rise to the next challenge: business process programming, a field that is in its infancy, and where there is the potential for significant impact. Competitive pressures are forcing enterprises to re-engineer and automate their business processes. Such processes are of long duration, complex, and error-prone. They consist of multiple steps that need to be coordinated; that may be executed by application programs, machines, or humans in different roles across different organizations; and that may execute in heterogeneous, distributed computing environments. This paper introduces topics in business process programming that we believe will be of interest to the database programming community. These range from issues in modeling and specifying business processes, including new transactional models for capturing their execution semantics, to problems of efficient, scalable implementation in the heterogeneous distributing environments prevalent in typical enterprises.
Isolation of Non-O1 Vibrio cholerae Serovars from Oregon Coastal Environments (1986)

Water, sediment, and shellfish from three Oregon estuaries were cultured for pathogenic Vibrio species. Non-O1 serovars of V. cholerae were the most common pathogenic Vibrio species recovered. Non-O1 V. cholerae were isolated from all three estuaries sampled, covering an area of about 170 miles along the Oregon coast. Non-O1 V. cholerae were isolated from water and sediment, but not shellfish, at temperatures ranging from 11 to 19 degrees C and salinities of 2.3 to 26 per thousand. Sixteen isolates representing 12 different non-O1 serovars were identified, while four non-O1 V. cholerae isolates failed to react with any of the 54 antisera tested. These results indicate that non-O1 V. cholerae serovars can be found over a large geographic area and under a variety of environmental conditions. These organisms are apparently an autochthonous component of these estuarine microbial communities.
Agar gel electrophoretic determination of glycosylated hemoglobin: effect of variant hemoglobins, hyperlipidemia, and temperature. (1981)

We investigated the effect of temperature, variant hemoglobins, and hyperlipidemia on determination of glycosylated hemoglobin by an electrophoretic method (Clin. Chem. 26: 1598-1602, 1980). We found that: (a) temperature variations ranging from 4 to 30 degrees C were without effect on results obtained by electrophoresis; (b) concurrent determination of glycosylated hemoglobin by electrophoresis and column-chromatography in blood specimens from 150 diabetic patients yielded almost identical mean values for both procedures when operations were carried out at 22 degrees C; (c) electrophoretic determination of glycosylated hemoglobin in whole-blood hemolysate was not affected by concentration of triglycerides; and (d) unlike column-chromatographic procedures, which underestimate the percentage of glycosylated hemoglobin in patients with hemoglobin S and C, the electrophoretic method accurately determined the proportion of glycosylated hemoglobin in these hemoglobinopathies. Evidently, electrophoresis on agar gel is an excellent alternative to cation-exchange column-chromatographic methods for glycosylated hemoglobin.
The Need for Temperature-Aware Storage Systems (2006)

Storage has become ubiquitous. Disk drives are commonplace in most laptops and desktops. In addition, they are used in large numbers in high-end server systems. Storage devices has also proliferated the consumer electronics market with their use in products like cameras, and portable music devices. This widespread usage of disks has been the result of tremendous growth in both the density and speed of these devices. Over the past two decades, we have been enjoying a 40 percent annual growth in the data rate of disks, due to innovations in the recording technology coupled with a scaling up of the drive RPM. Since raising the RPM increases the heat that is generated due to viscous dissipation by nearly a cubic factor, in order to design the drives for a constant thermal envelope, the platter sizes are also shrunk, as the latter has a fifth power impact on the temperature. In this paper, it shall be shown that this thermal-constrained scaling is going to be very challenging to sustain even for very small platter sizes, causing a significant slowdown in the pace of performance growth in future drives. Using real workloads, the need for continued scaling of the data rate is motivated. Some simple techniques will be presented that can be employed to overcome these effects. Finally, it will also be shown that managing temperature in disks cannot necessarily be tackled merely via energy saving techniques
Natriuretic peptides in embryonic stem cell-derived cardiomyocytes and their receptors in the CNS. (2009)

The natriuretic peptides (NPs) are a family of related hormones that play important roles in the cardiovascular homeostasis, cell growth and neuroendocrine functions. Recently, they have emerged as potentially important clinical biomarkers in heart failure. The heart secretes two major natriuretic peptides: atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), while C-type natriuretic peptide (CNP) is mainly secreted from the brain and blood vessels. The physiological effects of NPs are initiated by binding to natriuretic peptide receptors (NPRs), which are widely distributed in several organs. This review describes: the expression of natriuretic peptides in the cardiomyocytes differentiated from ES cells and their role in the cardiomyocyte development. We also describe the detailed distribution of NPRs in the central nervous system and their possible functions in various brain regions.
Compare the differences of synonymous codon usage between the two species within cardiovirus (2011)

The overall extents of codon usage bias in both EMCV and ThV are low. The mutational pressure is the main factor that determines the codon usage bias, but the (C+G) content plays a more important role in codon usage bias for ThV than for EMCV. The synonymous codon usage pattern in both EMCV and ThV genes is gene function and geography specific, but not host specific. Maybe the serotype is one factor effected the codon bias for ThV, and location has no significant effect on the variations of synonymous codon usage in these virus genes.
ChemInform Abstract: THE SYNTHESIS AND STRUCTURE OF PENTACARBONYL (5H‐DIPYRROLO(1,2‐C:2′,1′‐E)IMIDAZOL‐5‐YL)MANGANESE (1985)

Abstract Das Li‐Salz (II) reagiert bei ‐78°C in THF mit Pentacarbonylchloromangan zu einer Mischung von Produkten, aus der neben (IV) und dem freien Liganden (I) die Titelverbindung (III) chromatographisch isoliert werden kann.
<title>Correction of image intensifier distortion for three-dimensional x-ray angiography</title> (1995)

An algorithm has been developed to correct spatial distortion in image intensifier-based projections for three-dimensional (3D) angiographic reconstruction. A piecewise spatial warping technique is used to calculate a set of correction lookup tables which store the row and column subpixel spatial shifts, based on a reference grid image. Pixel amplitudes in the corrected image are determined from bilinear interpolation of the four surrounding pixels in the observed image. The method has been tested using an x-ray imaging chain with a 30-cm image intensifier positioned at various angular orientations and x-ray source distances. Prior to distortion correction, the maximum error between observed and expected reference point locations was found to be 14 mm. After correction, the maximum and mean errors were 0.23 mm and 0.053 mm, respectively.
Dosage de la morpholine sur les fruits par LC-MS/MS (2012)

L'usage de la morpholine est interdit dans la Communauté européenne. Ce biocide est souvent rencontré dans des produits du tiers monde où il est ajouté à des cires protégeant les fruits contre la déshydratation. La détection en Grande-Bretagne de ce biocide dans des pommes en provenance du Chili, du
Iloprost for Additional Anticoagulation in Continuous Renal Replacement Therapy—A Pilot Study (2007)

Additional administration of iloprost prolonged the filter run time of continuous veno-venous hemofiltration (CVVH) in this setting and attenuated the fall in platelet count during CRRT.
Molecular Mechanisms of Ischemic Neuronal Cell Death - With Relevance to Alzheimers Disease (2006)

There are many similarities in molecular mechanisms of neuronal cell death observed in ischemic stroke and Alzheimer's disease. From point of organelle damage, we introduced molecular events seen in ischemic stroke, and compared the findings with that observed in Alzheimer's disease. In the brain after ischemia, transmembrane potential and ion gradient are disturbed at very early stage. Several drugs are aimed to minimize this change, some of which were effective in experimental models. Calcium blocker and glutamate antagonist were also effective for Alzheimer's disease. As for mitochondrial and endoplasmic reticulum damage, both disorders share common pathological findings such as pro-apoptotic signals activation. However, there are some molecules which are neuroprotective in Alzheimer's disease but pro-apoptotic in ischemic neurons. We need to be so careful for judging the significance of a phenomenon obtained by an experiment. Lysosome, called as suicide bag, play important roles both in the brain of ischemic stroke and Alzheimer's disease. Leak of lysosomal enzymes influence, at least partially, the fate of neurons under pathological conditions in both disorders.
New presentation of familial medullary thyroid carcinoma in 87-year-old patient with high-riskRETproto-oncogene codon 620 mutation (2008)

In this case, the progress of hereditary medullary thyroid carcinoma was unique, considering the late presentation of medullary thyroid carcinoma despite the presence of the high-risk RET proto-oncogene codon 620 mutation. The authors wish to highlight the importance of this case, as it may present a counter-argument to the current recommendations for early, prophylactic thyroidectomy in codon 620 mutation carriers in order to prevent early development of medullary thyroid carcinoma.
Separate domain formation in Ge2Sb2Te5–SiOx mixed layer (2006)

We report separate domain formation in cosputtered Ge2Sb2Te5–SiOx mixed layer, with SiOx amount less than 10mol%. As-prepared Ge2Sb2Te5–SiOx layer exhibits amorphous phase with separate domains smaller than 20nm. The separation maintains after thermal annealing, which results in crystallization into fcc phase. The crystallization activation energies of Ge2Sb2Te5–SiOx are obtained as 4.99 and 6.44eV for mixed layers containing 5.3 and 8.4mol% SiOx, respectively. Those are larger than 2.75eV of pure Ge2Sb2Te5. Furthermore, the mixed layer exhibits sublimation at increased temperature. These are interpreted as formation of Ge2Sb2Te5-rich domains separated from each other by SiOx-rich domains.
Katalytische Oxidation von Isomaltulose (1995)

Abstract Catalytic Oxidation of Isomaltulose . In carbohydrate chemistry the noble metal catalyzed oxidation is known as a “clean” reaction with high selectivity. Applied to the disaccharide ketose isomaltulose, the reaction gives two monooxidized and one dioxidized products contrary to the selectivity rules, which were earned for monosaccharides by Heyns in fundamental investigations. However, the kinetic studies of this reaction show that the dioxidation is a two step reaction in which the second step is inhibited by high isomaltulose concentrations. This could be used for the development of a process of technical interest for preparing the monooxidized products because the continous removal of the ionic reaction products with an electrodialysis allowed the realization of optimal reaction conditions. Klein et al. show that these monooxidized products are important intermediates for semisynthetic polymers.
The Daytime ImpactofDSM-5Insomnia Disorder (2012)

The severity of daytime impact of DSM-5 insomnia disorder varies by insomnia type. This finding has implications for the evaluation and management of insomnia in clinical practice.
A Preliminary Study of Cu Exposure Effects upon Alzheimer’s Amyloid Pathology (2020)

A large body of evidence indicates that dysregulation of cerebral biometals (Fe, Cu, Zn) and their interactions with amyloid precursor protein (APP) and Aβ amyloid may contribute to the Alzheimer's disease (AD) Aβ amyloid pathology. However, the molecular underpinnings associated with the interactions are still not fully understood. Herein we have further validated the exacerbation of Aβ oligomerization by Cu and H<sub>2</sub>O<sub>2</sub> in vitro. We have also reported that Cu enhanced APP translations via its 5' untranslated region (5'UTR) of mRNA in SH-SY5Y cells, and increased Aβ amyloidosis and expression of associated pro-inflammatory cytokines such as MCP-5 in Alzheimer's APP/PS1 doubly transgenic mice. This preliminary study may further unravel the pathogenic role of Cu in Alzheimer's Aβ amyloid pathogenesis, warranting further investigation.
The in Vivo Metabolism of Somatostatin 28: Possible Relationship between Diminished Metabolism and Enhanced Biological Action* (1982)

We have compared the metabolism of infused somatostatin 14 (SS14) and somatostatin 28 (SS 28) in anesthetized dogs. After iv infusion of either peptide, plasma SS-like immunoreactivity (SLI) coeluted from Bio-Gel P10 columns with the corresponding synthetic peptide marker. The hepatic extraction, renal extraction, MCR, and plasma half-life of plasma SLI and after SS28 infusion were 11.0 +/- 1.5%, 50 +/- 4.8%, 9.9 +/- 1.4 ml/kg.min, and 2.8 +/- 0.3 min, respectively. Corresponding values after SS14 infusion were 43.1 +/- 7.4%, 82.2 +/- 6.6%, 21.9 +/- 6.5 ml/kg.min, and 1.7 +/- 0.2 min. These differences between SS28 and SS14 were all statistically significant (P less than 0.05). When equimolar amounts of each peptide were given as bolus injections, both led to a significant reduction in portal venous blood flow. After the injection of SS14, the reduction in flow was short-lived and returned to baseline by 4 min. However, between 2-7.5 min after the injection of SS28, the reduction in blood flow was significantly greater than that induced by SS14, and returned to baseline only by 15 min. These studies indicate that the metabolism of plasma SLI is significantly slower during the steady state infusion of SS28 in pharmacological doses than after similar infusions of SS14. SS28 led to a more prolonged reduction in portal blood flow than SS14; this effect is probably due to its slowed metabolism. This suggests that further modification of the SS28 molecule may increase its therapeutic potential by slowing its in vivo metabolism.
Targeting the Early Endosome-to-Golgi Transport of Shiga Toxins as a Therapeutic Strategy (2020)

Shiga toxin (STx) produced by <i>Shigella</i> and closely related Shiga toxin 1 and 2 (STx1 and STx2) synthesized by Shiga toxin-producing <i>Escherichia coli</i> (STEC) are bacterial AB<sub>5</sub> toxins. All three toxins target kidney cells and may cause life-threatening renal disease. While <i>Shigella</i> infections can be treated with antibiotics, resistance is increasing. Moreover, antibiotic therapy is contraindicated for STEC, and there are no definitive treatments for STEC-induced disease. To exert cellular toxicity, STx, STx1, and STx2 must undergo retrograde trafficking to reach their cytosolic target, ribosomes. Direct transport from early endosomes to the Golgi apparatus is an essential step that allows the toxins to bypass degradative late endosomes and lysosomes. The essentiality of this transport step also makes it an ideal target for the development of small-molecule inhibitors of toxin trafficking as potential therapeutics. Here, we review the recent advances in understanding the molecular mechanisms of the early endosome-to-Golgi transport of STx, STx1, and STx2, as well as the development of small-molecule inhibitors of toxin trafficking that act at the endosome/Golgi interface.
Effects of increasing PEP-NS on nursery pig performance (2010)

A total of 180 nursery pigs (PIC 1050, initially 14.2 lb and 28 d of age) were used in a 24-d study to evaluate the effects of increasing PEP-NS on nursery pig performance. PEP-NS is a combination of porcine intestinal mucosa and by-products of corn wetmilling. There were 5 pigs per pen and 6 pens per treatment. There were 6 dietary treatments: a negative control containing no specialty proteins, the negative control diet with 3, 6, 9, or 12% PEP-NS, or the negative control with 6% select menhaden fish meal (SMFM). The diet with 6% SMFM contained the same amount of soybean meal as the diet with 6% PEP-NS. A common pretest diet was fed in pellet form for the first 7 d post weaning. Experimental diets were fed in meal form from d 0 to 14, and a common diet was fed from d 14 to 24. From d 0 to 14, increasing PEP-NS increased (quadratic, P < 0.01) ADG, ADFI, and F/G, with the greatest response observed in pigs fed 9% PEP-NS. There were no differences (P > 0.10) between pigs fed 6% PEP-NS or 6% SMFM. When pigs were fed a common diet from d 14 to 24, there were no differences in performance between treatments. Overall, from d 0 to 24, pigs fed increasing PEP-NS had improved (quadratic; P < 0.01) ADG and F/G, with the greatest improvement seen as PEP-NS increased from 3 to 6%. These results suggest that feeding 6% to 9% PEP-NS in Phase 2 nursery pig diets is suitable replacement for 6% SMFM.; Swine Day, Manhattan, KS, November 18, 2010
The Effect of Polyethylene Glycol (PEG) on TiO2 Thin Films via Sol-Gel Method (2020)

Abstract This research focus on the effect of polyethylene glycol (PEG) on TiO 2 thin film. Sol-gel method is the best method which tends to be used due to its simplicity, good chemical homogeinity and high purity of the product. Titanium (IV) isopropoxide, isopropanol and acetic acid are the three different chemical which being used to make sol solution. The samples was then will annealed at three different temperature which are 400 °C, 500 °C and 600 °C to observed the phase composition of TiO 2 added PEG thin film and pure TiO 2 by using x-ray diffraction (XRD) analysis and the structural surface by using scanning electron microscope (SEM) analysis. The XRD analysis show the anatase phase present for the sample of pure TiO 2 thin film and rutile phase present for the sample of TiO 2 added PEG thin film. The micrograph of SEM show that with the addition of PEG at high temperature will give the analysis of flaky large cracked which is not separated to each other on the surface coating. Meanwhile, pure TiO 2 give the result of irregular shape structure of the film.
Fabrication and Applications of Fiber Bragg Grating- A Review (2015)

In this paper, the brief introduction of Fiber Bragg Grating , its significant applications, sensing principles, proper ties, fabrication and the basic designing of FBG have been discussed. FBG's are relatively simple to manufacture, small in dim ension, low cost and exhibits good immunity from the electromegnatic radiations. The former inceptions and the essential techniques of fiber Bragg grating fabrication are described. This paper presents a comprehensive and systematic overview of FBG technology.
Circulating miRNAs Respond to Denosumab Treatment After 2 Years in Postmenopausal Women With Osteoporosis—the MiDeTe study (2022)

Two years of DMAB treatment resulted in upregulation of 7 miRNAs, 4 of which are mainly transcribed in monocytes, indicating a potential impact of DMAB on circulating osteoclast precursor cells. These changes were associated to BMD gain and BTM suppression and could therefore be useful for monitoring DMAB treatment response.
Investigation of frequency of active Borna disease virus infection in Scottish blood donors (2004)

The results indicate that BDV is not widely spread in the UK human population and does not represent a risk as a transfusion-transmitted agent.
ChemInform Abstract: Preparation of 1‐Azacyclodeca‐3,8‐diynes and 1,6‐Diazacyclodeca‐3,8‐diynes. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
S-acylation regulates the trafficking and stability of the unconventional Q-SNARE STX19 (2018)

STX19 is an unusual Q<sub>a</sub>-SNARE as it lacks a C-terminal transmembrane domain. However, it is efficiently targeted to post-Golgi membranes. Here, we set out to determine the intracellular localisation of endogenous STX19 and elucidate the mechanism by which it is targeted to membranes. We have found that a pool of STX19 is localised to tubular recycling endosomes where it colocalises with MICAL-L1 and Rab8 (which has Rab8a and Rab8b forms). Using a combination of genetic, biochemical and cell-based approaches, we have identified that STX19 is S-acylated at its C-terminus and is a substrate for several Golgi-localised S-acyltransferases, suggesting that STX19 is initially S-acylated at the Golgi before trafficking to the plasma membrane and endosomes. Surprisingly, we have found that S-acylation is a key determinant in targeting STX19 to tubular recycling endosomes, suggesting that S-acylation may play a general role in directing proteins to this compartment. In addition, S-acylation also protects STX19 from proteosomal degradation, indicating that S-acylation regulates the function of STX19 at multiple levels.This article has an associated First Person interview with the first author of the paper.
Diastereoselective Pd/In Bimetallic Inter—Intramolecular (Class 2) Cascade Reactions of Allenyl‐Imines and Aryl Iodides. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Energy-saving synthesis of potassium iodatevia electrolysis of potassium iodine and O2in a membraneless cell (2011)

An electrochemical process for producing potassium iodate based on oxidation of KI coupled with oxygen reduction reaction in a newly designed cell is reported. By using an Ag-modified oxygen reduction cathode, the proposed cell needed no ion exchange membrane, and the current efficiency for KIO3 was confirmed to be over 96%, the corresponding cell voltage was only 0.7–0.8 V.
Control of a Direct-Drive Arm (1983)

A direct-drive arm is a mechanical arm in which the shafts of articulated joints are directly coupled to the rotors of motors with high torque. Since the arm does not contain transmission mechanisms between the motors and their loads, the drive system has no backlash, small friction, and high mechanical stiffness, all of which are desirable for fast, accurate, and versatile robots. First, the prototype robot is described, and basic feedback controllers for single-link drive systems are designed. Second, feedforward compensation is discussed. This compensation significantly reduces the effect of interactions among multiple joints and nonlinear forces. The experiments showed the excellent performance of the direct-drive arm in terms of speed and accuracy.