gebhart/patrepeval huggingface dataset:
The Value Of Multi-Component Tem Data For The Estimation Of Uxo Target Parameters (2004)

Two multi-component multi-gate data sets from the Naval Research Laboratory’s Baseline&lt;br&gt;Ordnance Classification Test Site at Blossom Point, one acquired statically with a Geonics EM61-3D-&lt;br&gt;3C and the other acquired dynamically with a Zonge NanoTEM system (DNT), are analyzed to&lt;br&gt;determine the relative classification performance of the two systems. Not surprisingly, our classification&lt;br&gt;performance is better with 3-component static data than it is with the 3-component dynamic data.&lt;br&gt;Confirming published work by Grimm [4], classification is significantly improved when it is applied to&lt;br&gt;the 3-component static data than when it is applied to a decimated data set consisting of only a single (z)&lt;br&gt;component. However, early analyses of the dynamic data indicated that horizontal components provide&lt;br&gt;marginal, if any, improvements in classification. Noise analyses of data from the two systems show that&lt;br&gt;noise levels in the EM61-3D data set are approximately 40dB lower than those in the DNT system and&lt;br&gt;that noise levels in the horizontal components at late times are 2-5 times higher in the vertical&lt;br&gt;component. Noise reduction in statically acquired data can be attributed to stacking (~20dB) and the&lt;br&gt;elimination of microphonic noise from antenna cart movements. With dynamically acquired data, the&lt;br&gt;higher noise levels in the horizontal components together with uncertainties in antenna position and&lt;br&gt;attitude are most likely the reason that the horizontal components do not unequivocally improve&lt;br&gt;classification performance in the dynamic data.
Emissive and reflective properties of curved displays in relation to image quality (2016)

Different aspects of the characterization of curved displays are presented. The limit of validity of viewing angle measurements without angular distortion on such displays using goniometer or Fourier optics viewing angle instrument is given. If the condition cannot be fulfilled the measurement can be corrected using a general angular distortion formula as demonstrated experimentally using a Samsung Galaxy S6 edge phone display. The reflective properties of the display are characterized by measuring the spectral BRDF using a multispectral Fourier optics viewing angle system. The surface of a curved OLED TV has been measured. The BDRF patterns show a mirror like behavior with and additional strong diffraction along the pixels lines and columns that affect the quality of the display when observed with parasitic lighting. These diffraction effects are very common on OLED surfaces. We finally introduce a commercial ray tracing software that can use directly the measured emissive and reflective properties of the display to make realistic simulation under any lighting environment.
Introduction (2017)

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Staphylococcus aureus gene expression in a rat model of infective endocarditis (2014)

Background: Diabetes mellitus is a frequent underlying comorbidity in patients with Staphylococcus aureus endocarditis, and it represents a risk factor for complications and a negative outcome.The pathogenesis of staphylococcal endocardial infections in diabetic hosts has been poorly characterized, and little is known about S. aureus gene expression in endocardial vegetations.Methods: We utilized a rat model of experimental S. aureus endocarditis to compare the pathogenesis of staphylococcal infection in diabetic and nondiabetic hosts and to study the global S. aureus transcriptome in endocardial vegetations in vivo.Results: Diabetic rats had higher levels of bacteremia and larger endocardial vegetations than nondiabetic control animals.Microarray analyses revealed that 61 S. aureus genes were upregulated in diabetic rats, and the majority of these bacterial genes were involved in amino acid and carbohydrate metabolism.When bacterial gene expression in vivo (diabetic or nondiabetic endocardial vegetations) was compared to in vitro growth conditions, higher in vivo expression of genes encoding toxins and proteases was observed.Additionally, genes involved in the production of adhesins, capsular polysaccharide, and siderophores, as well as in amino acid and carbohydrate transport and metabolism, were upregulated in endocardial vegetations.To test the contribution of selected upregulated genes to the pathogenesis of staphylococcal endocarditis, isogenic deletion mutants were utilized.A mutant defective in production of the siderophore staphyloferrin B was attenuated in the endocarditis model, whereas the virulence of a surface adhesin (ΔsdrCDE) mutant was similar to that of the parental S. aureus strain.Conclusions: Our results emphasize the relevance of diabetes mellitus as a risk factor for infectious endocarditis and provide a basis for understanding gene expression during staphylococcal infections in vivo.
The Cyclic AMP-Epac1-Rap1 Pathway Is Dissociated from Regulation of Effector Functions in Monocytes but Acquires Immunoregulatory Function in Mature Macrophages (2006)

cAMP mediates its intracellular effects through activation of protein kinase A (PKA), nucleotide-gated ion channels, or exchange protein directly activated by cAMP (Epac). Although elevation of cAMP in lymphocytes leads to suppression of immune functions by a PKA-dependent mechanism, the effector mechanisms for cAMP regulation of immune functions in monocytes and macrophages are not fully understood. In this study, we demonstrate the presence of Epac1 in human peripheral blood monocytes and activation of Rap1 in response to cAMP. However, by using an Epac-specific cAMP analog (8-CPT-2'-O-Me-cAMP), we show that monocyte activation parameters such as synthesis and release of cytokines, stimulation of cell adhesion, chemotaxis, phagocytosis, and respiratory burst are not regulated by the Epac1-Rap1 pathway. In contrast, activation of PKA by a PKA-specific compound (6-Bnz-cAMP) or physiological cAMP-elevating stimuli like PGE(2) inhibits monocyte immune functions. Furthermore, we show that the level of Epac1 increases 3-fold during differentiation of monocytes into macrophages, and in monocyte-derived macrophages cAMP inhibits FcR-mediated phagocytosis via both PKA and the Epac1-Rap1 pathway. However, LPS-induced TNF-alpha production is only inhibited through the PKA pathway in these cells. In conclusion, the Epac1-Rap1 pathway is present in both monocytes and macrophages, but only regulates specific immune effector functions in macrophages.
Cytostatisch wirkende Sulfoniumsalze, III.. Kinetische und Polarographische Untersuchungen zur Klärung ihres Wirkungs‐Chemismus (1964)

Abstract Die Reaktionen cytostatisch aktiver Sulfoniumsalze mit Hydroxyl‐ und Mercaptid‐lonen werden unter physiologischen pH‐Bedingungen untersucht. Die Geschwindigkeiten dieser Umsetzungen zeigen eindeutige Beziehungen zu den polarographischen Halbstufenpotentialen (E 1/2 ) der Sulfonium‐Kationen. In den statischen E 1/2 ‐Werten kommt die dynamische “Reaktivität” von Sulfoniumsalzen gut zum Ausdruck. Die Reaktionsbereitschaft gegenüber SH‐Gruppen wiederum zeigt Parallelen zur cytostatischen Aktivität und bestärkt die Theorie, daß wenigstens eines der Wirkungsprinzipien der Cytostatica auch der Sulfoniumsalz‐Reihe in einer Blockierung biologisch wichtiger SH‐Gruppen zu sehen ist.
The role of attractiveness in web image search (2011)

Existing web image search engines are mainly designed to optimize topical relevance. However, according to our user study, attractiveness is becoming a more and more important factor for web image search engines to satisfy users' search intentions. Important as it can be, web image attractiveness from the search users' perspective has not been sufficiently recognized in both the industry and the academia. In this paper, we present a definition of web image attractiveness with three levels according to the end users' feedback, including perceptual quality, aesthetic sensitivity and affective tune. Corresponding to each level of the definition, various visual features are investigated on their applicability to attractiveness estimation of web images. To further deal with the unreliability of visual features induced by the large variations of web images, we propose a contextual approach to integrate the visual features with contextual cues mined from image EXIF information and the associated web pages. We explore the role of attractiveness by applying it to various stages of a web image search engine, including the online ranking and the interactive reranking, as well as the offline index selection. Experimental results on three large-scale web image search datasets demonstrate that the incorporation of attractiveness can bring more satisfaction to 80% of the users for ranking/reranking search results and 30.5% index coverage improvement for index selection, compared to the conventional relevance based approaches.
Mono‐ and penta‐nuclear self‐assembled silver(I) complexes of pyrazolyl s‐triazine ligand; synthesis, structure and antimicrobial studies (2020)

The self‐assembled [Ag (PTDM)NO 3 ] ( 1 ), [Ag (PTDM) 2 (H 2 O)]ClO 4 . H 2 O ( 2 ) and [Ag 5 (PTDM) 4 (H 2 O) 6 (ClO 4 ) 4 ]ClO 4 . 2H 2 O ( 3 ) complexes were synthesized by the direct mixing of AgX (X = NO 3 ¯ or ClO 4 ¯) and 4,4′‐[6‐(3,5‐dimethyl‐ 1H ‐pyrazol‐1‐yl)‐1,3,5‐triazine‐2,4‐diyl]dimorpholine ( PTDM ) ligand in water–methanol mixture. The coordination numbers of silver range from three to five. Complex 3 is a rare case in which one nitrogen atom from the same s ‐triazine core of the PTDM ligand has a μ (1,1) bridging mode between Ag1 and Ag2 in the penta‐nuclear array with Ag1–N1 and Ag2–N1 distances of 2.666(4) and 2.418(3) Å, respectively. Its 3D topology has a kind of primitive dense packing derived from the α ‐Po type structure. Hirshfeld analysis showed that the percentages of the O … H hydrogen bonds were 32.4, 25.4, and 42.0% in complexes 1 – 3 , respectively. While the ligand showed no antimicrobial activity at the applicable concentration, the penta‐nuclear complex 3 had higher antibacterial (MIC = 3.7 μmol/L) and antifungal (14.6 μmol/L) potencies toward the tested microbes compared with complexes 1 and 2 . Also, the killing doses of 3 were in the range of 7.3–58.5 μmol/L compared with 18.2–291.1 and 20.1–160.6 μmol/L for 1 and 2 , respectively. It is clear that the higher Ag‐content in 3 could be the main reason for its higher antimicrobial activity.
Fixation d'anticorps par liaisons covalentes sur le polystyrène. Activation du support et utilisation répétée du système polystyrène anticorps après test immunoenzymatique (1986)

Abstract Antibodies were immobilized by covalent linkage on polystyrene balls for use in solid phase enzyme‐linked immunoassays: application for detection of K 99 + E. Coli in calves. The method eliminates the problem of antibody desorption noted in coventional enzyme‐linked immunosorbent assays which are based on simple adsorption on polystyrene. Further, the bond between antibodies and polystyrene balls is stable under conditions under which usually antibody — antigen complexes dissociate and permit re‐use of the immobilized antibodies for immunoassay.
Experimental Test of Local Hidden-Variable Theories (1972)

We have measured the linear polarization correlation of the photons emitted in an atomic cascade of calcium. It has been shown by a generalization of Bell's inequality that the existence of local hidden variables imposes restrictions on this correlation in conflict with the predictions of quantum mechanics. Our data, in agreement with quantum mechanics, violate these restrictions to high statistical accuracy, thus providing strong evidence against local hidden-variable theories.
Synthesis and Electrochemical Sensing Toward Heavy Metals of Bunch-like Bismuth Nanostructures (2009)

Large-scale bunch-like bismuth (Bi) nanostructures were the first time to be synthesized via two-step electrochemical deposition. The growth mechanism of the nanostructures was discussed. Such a designed bunch-like Bi electrode has high sensitivity to detect the heavy metal ions due to its unique three-dimensional structures and strong ability of adsorbing the heavy metal ions. The bunch-like Bi electrode's detection of heavy metals was statically performed using anodic stripping voltammetry (ASV). The detection in the Pb(II) concentration range of 2.5-50 mug/l was also performed. Based on the experimental results, this bunch-like Bi electrode can be considered as an interesting alternative to common mercury electrodes and bismuth film electrodes for possible use in electrochemical studies and electroanalytical applications.
Spectral characteristics of chest wall breath sounds in normal subjects. (1995)

These data define the boundaries of normal chest wall breath sounds and may be used as reference for comparison with abnormal sounds.
Generation of nonthermal continuum radiation in the magnetosphere (1982)

Generation of electromagnetic continuum radiation from electrostatic fluctuations near the upper hybrid resonance frequency has been calculated by using cold plasma theory in an inhomogeneous plasma near the plasmapause. It is shown that both the polarization and the amplitude of electromagnetic radiation are in good quantitative agreement with spacecraft observations for nonthermal continuum radiation.
Reversal of Reflex-Induced Myocardial Ischemia by Median Nerve Stimulation (1998)

These results suggest that stimulation of the median nerve to mimic electroacupuncture diminishes regional myocardial ischemia triggered by a sympathetically mediated increase in cardiac oxygen demand. The mechanism of this effect is related to reduction in cardiac oxygen demand, secondary to a diminished pressor response. These data provide the first documentation of the physiological mechanisms underlying the possible beneficial effect of electroacupuncture in the context of restricted coronary blood flow and augmented myocardial oxygen demand.
Analysis of tryptophan biosynthesis in Zymomonas mobilis (1987)

The enzymes and genes of tryptophan biosynthesis have been investigated in order to learn about regulation and gene organization in Zymomonas mobilis. Zymomonas is an unusual genus of Gram-negative bacteria, potentially important for industrial fermentation of ethanol. Zymomonas is also interesting for its unique physiology and its phylogenetic relationships to other bacteria. Knowledge of the regulation and organization of trp genes may be useful for evaluating the significance of the regulation and organization of the other metabolic genes in Z. mobilis. In addition, information on tryptophan biosynthesis in Z. mobilis may lend insight into the evolution of this pathway in bacteria. The first step in the investigation was to isolate tryptophan auxotrophs. Twelve trp mutants were isolated after nitrosoguanidine mutagenesis. Six mutants appeared to be analogous to E. coli trp E mutants which are defective in anthranilate synthase. Five of the mutants did not have tryptophan synthase B activity and were classified as trp B mutants. One mutant lacking tryptophan synthase activity grew on indole and was classified as a trp A mutant. Some of these mutants were used in two experiments to investigate the regulation of tryptophan biosynthesis. First, a trp B mutant accumulated indole only if supplied with growth limiting concentrations of tryptophan. This result suggested that the carbon flow through the pathway was regulated. The second experiment suggested that not all of the trp genes or enzymes are regulated in response to the concentration of tryptophan. Tryptophan synthase and indoleglycerol phosphate synthase did not vary when trp mutants or the wild type were grown on limiting or excess tryptophan. The organization of the Z. mobilis trp genes was examined by genetic cloning, complementation analysis, restricting mapping, and Southern hybridization. Five Z. mobilis trp genes (D,C,F,B, and A) were cloned by complementation of E. coli and P. putida trp mutants. The trp F, B, adnd A genes were clustered, but not closely associated with the trp D and trp C genes. These results suggest that there are at least two trp gene clusters in Z. mobilis.
Correlation between porosity and permeability of stainless steel filters with gradient porosity produced by SLS/SLM (2019)

Purpose Porous structures have been widely used in filtration, medical implants and aerospace field. In the filtration field, the study of permeability of the porous structures is of great importance. This paper aims to study the influence of selective laser sintering/melting (SLS/SLM) process parameters on porosity and permeability of stainless steels filters with gradient porosity (FGM). Design/methodology/approach AISI 316L stainless steel powder was used to manufacture FGM filters by varying the hatch distance while other process parameters were fixed. The relationship between porosity and permeability of such FGM filters was investigated by means of Archimedes’ and Forchheimer’s laws. The gradient of porosity was also analyzed by means of micro-computed tomography. Findings The results have confirmed the ability of SLS/SLM in controlling porosity of the final product by varying the hatch distance. Further, the results allow to assume that FGM filters will have particle retention capacity related to lowest porosity value (which in turn is associated with the lowest hatch distance value used), while it will work at lower pressure drops – or at higher flow rates for equal pressure drop – when compared to a filter without gradient porosity. Originality/value Some research found in recent literature has showed the relationship between SLS/SLM process parameters and permeability of stainless steel porous structures. However, this paper fulfils the need to understand the relationship between SLS/SLM process parameters, porosity and permeability behavior of functionally graded porous structures (FGM filters).
Electronic and Nuclear Dynamics of the Accessory Bacteriochlorophylls in Bacterial Photosynthetic Reaction Centers from Resonance Raman Intensities (1997)

Resonance Raman spectra and absolute Raman scattering intensities of the Franck−Condon coupled vibrational modes of the accessory bacteriochlorophylls (B) in the photosynthetic reaction center from Rb. sphaeroides have been obtained with excitation in their 800 nm Qy absorption band. Although the relative Raman intensities are unchanged when the temperature is reduced from 278 to 95 K, the absolute Raman scattering intensity is found to increase by a factor of ∼4 at 95 K. A self-consistent multimode vibronic model for the excited-state properties of B has been developed that provides a unique fit to the absorption band and the Raman cross sections at both temperatures using a total S (linear electron−nuclear coupling factor) of 0.32 and an effective electronic dephasing time of ∼54 fs at 278 K and ∼210 fs at 95 K. The Raman scattering cross sections are consistent with an electronic structure model where the two B chromophores absorb and scatter independently. The Raman cross sections scale as 1/T2 in the 95−298 K range, suggesting that the pure dephasing time, if modeled as a Gaussian (slow-modulation limit), decreases linearly with temperature. At room temperature, the electronic dephasing time is controlled by bath-induced dephasing processes rather than the energy transfer time from the excited state of B. The electronic and nuclear relaxation parameters derived here provide a more quantitative picture of the time scale and structural relaxation of the chromophores involved in energy transfer in reaction centers.
Contribution of IFN-?? to acute allograft failure in murine cardiac transplants: Role in vascular thrombosis (1998)

390 We investigated the role of IFN-γ in acute cardiac allograft failure using IFN-γ deficient (GKO) mice. Without immunosuppression, BALB/c[H-24] into wild type C57BL/6 [B6, H-2b] total allogeneic mismatched cardiac grafts ceased beating at 7.2 ± 0.2 days (n=9); BALB/c hearts transplanted into B6GKO ceased beating at 6.6 ± 0.1 days(n=6). Although grafts in both wild type and GKO recipients showed comparably severe mononuclear cell infiltration (rejection), allografts in GKO recipients also showed profound acute coagulation necrosis with vascular thrombosis demonstrable by fibrin staining. By immunohistochemical staining, plasminogen activator inhibitor-1 (PAI-1) was strikingly increased in allografts transplanted into B6GKO hosts relative to B6 wild types; no difference was seen in tissue plasminogen activator staining for allografts in wild type vs GKO hosts. Without immunosuppression, MHC I-mismatched allografts, characterized by a predominant CD8 T cell response (bm1 into B6), functioned for at least 12 weeks (n=10) and showed only moderate acute rejection. In contrast, bm1 into B6GKO allografts ceased beating at 7.7± 0.7 days (n=7), and showed rejection with coagulative necrosis and vascular thrombosis. Without immunosuppression, MHC II-mismatched allografts, characterized by a predominant CD4 T cell response (bm12 into B6), ceased beating at 31.5 ± 6.2 days (n=6), and showed severe rejection. In contrast, bm1 2 into B6GKO allografts functioned for at least 12 weeks and showed only moderate rejection without coagulative necrosis or vascular thrombosis. To specifically evaluate the role of T cell subpopulations, CD4 and/or CD8 T cells were selectively depleted in recipients by appropriate mAb administration pre-transplant, as shown below. Graft survival times were: BALB/c into B6 (anti-CD4): 38.3 ± 6.7 days (n=3), BALB/c into B6GKO(anti-CD4): 10.7 ± 5.0 days (n=3), BALB/c into B6 (anti-CD8): 12.0± 2.3 days (n=5), BALB/c into B6GKO (anti-CD8): 14.3 ± 1.5 days(n=3), BALB/c into B6 (anti-CD4 and CD8): 31.7 ± 3.2 days (n=9), BALB/c into B6GKO (anti-CD4 and CD8): 38.2 ± 7.3 days (n=5). All grafts in the above demonstrated comparably severe rejection; notably, coagulative necrosis and thrombosis were not seen. The results suggest that acute cardiac allograft failure, particularly in GKO, may include a component of vascular thrombosis due to increased PAI-1 activity. Increased thrombosis is particularly evident in the setting of MHC I mismatches, but cannot be wholly attributed to an effect of CD8T cells.
Monoclonal Antibodies against the CεmX Domain of Human Membrane-Bound IgE and Their Potential Use for Targeting IgE-Expressing B Cells (2002)

We have prepared several human mIgE-specific mAbs. The potential of the mAbs on targeting mIgE+ B cells was demonstrated by CDC analysis.
Assessing the Use of Speech and Language Measures in Relation to Parental Perceptions of Development After Early Cochlear Implantation (2008)

Our results demonstrate the importance of measuring multiple outcome measures after early pediatric CI. The degree to which an outcome measure reflects childhood development as perceived by parents may be affected by the child's age. Measures that are based on parental report and broader outcome measures focused on verbal language offer the potential for a fuller understanding of the true effectiveness of early implantation.