gebhart/patrepeval huggingface dataset:
T Helper Cell Type 1–associated and Cytotoxic T Lymphocyte–mediated Tumor Immunity Is Impaired in Interleukin 4–deficient Mice (1999)

It is widely accepted that cellular immune responses are induced by CD4(+) T helper 1 (Th1) cells secreting interleukin (IL)-2 and interferon (IFN)-gamma. Tumor immunity is often mediated by cytotoxic T lymphocytes (CTLs) whose activation is supported by Th1 cytokines. Since IL-4 directs Th2 development and has been shown to inhibit Th1-dominated responses, we assumed that IL-4-deficient (IL-4(-/-)) mice would develop vigorous CTL-mediated tumor immunity compared with IL-4-competent (IL-4(+/+)) mice. Surprisingly, IL-4(-/-) mice were severely impaired to develop tumor immunity to both a mammary adenocarcinoma line and a colon carcinoma line. The lack of tumor immunity in IL-4(-/-) mice was associated with reduced IFN-gamma production, diminished levels of tumor-reactive serum IgG2a, and undetectable CTL activity, indicating a defective Th1 response in the absence of endogenous IL-4. Anti-IL-4 monoclonal antibody blocked tumor immunity in IL-4(+/+) mice when administered at the time of immunization but not at the time of challenge. Additionally, tumor immunity could be induced in IL-4(-/-) mice, if IL-4 was provided by gene-modified cells together with immunizing tumor cells. These results demonstrate that tumor immunity requires IL-4 in the priming phase for the generation of effector cells rather than for their maintenance and exclude secondary, developmental defects in the "knockout" strain. Together, our results demonstrate a novel and previously unanticipated role of IL-4 for the generation of Th1-associated, CTL-mediated tumor immunity.
Correction to: Quenching of singlet oxygen by natural and synthetic antioxidants and assessment of electronic UV/Visible absorption spectra for alleviating or enhancing the efficacy of photodynamic therapy (2020)

The original article1 contains an error in the author affiliation. The author affiliation is corrected as below: Kaneez Fatima1;2, Nusrat Masood1, Suaib Luqman1;2 1CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow-226015, Uttar Pradesh, India2Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, Uttar Pradesh, India REFERENCES 1. Fatima K, Masood N, Luqman S. Quenching of singlet oxygen by natural and synthetic antioxidants and assessment of electronic UV/Visible absorption spectra for alleviating or enhancing the efficacy of photodynamic therapy. Biomedical Research and Therapy. 2016;3(2):514–527.
Variation in 8-methoxypsoralen profiles during long-term psoralen plus ultraviolet A therapy and correlations between serum 8-methoxypsoralen levels and chromametric parameters. (1991)

Three serum 8-methoxypsoralen (8-MOP) kinetics tests were performed on 15 patients undergoing PUVA therapy. The first test was carried out before beginning PUVA treatment, the 2nd one at the 10th session and the 3rd test at the 20th PUVA session. Blood samples were taken every 30 min after the drug was taken and a standard meal ingestion during 3 h to determine the serum 8-MOP peak level and corresponding time. For 14 patients, UVA-induced erythema was measured with a Minolta CR 200 chromameter, 3 (before beginning PUVA treatment, just before 10th session and 48 h later) or 5 times (before beginning PUVA treatment, just before 10th session and 48 h later, just before 20th session and 48 h later). There was a wider distribution of serum 8-MOP peak levels in the 3rd test than in 2nd one and in the 2nd one than in the first one. These facts suggest a heterogeneity in 8-MOP metabolism in the 15 patients: 11 patients showed an earlier serum 8-MOP peak and an earlier appearance of the drug in blood in the 3rd and 2nd test than in the first one. For 9 of these 11 patients, serum 8-MOP peak levels were higher and higher from the first profile to the 3rd one, suggesting an inhibition of 8-MOP metabolism in time. In the remaining 4 patients, the 8-MOP peak time and the appearance of the drug in blood were delayed in the 3rd test compared with the first profile.(ABSTRACT TRUNCATED AT 250 WORDS)
Monolithic cascade device in low power converter applications with wide range input voltage (2006)

An improved converter for low power and wide range input voltage, which is particularly suitable for auxiliary uses in three-phase grid of industrial applications, is studied. A flyback quasi-resonant topology has been chosen, which offers the good characteristics of high voltage operations and good efficiency. A comparison is performed among available kinds of semiconductor devices with good peculiarities for the specific topic. In particular the analysis focuses on MOSFET and cascode devices. The latter component shows good characteristics in this specific application of high voltage operations at high switching frequency and low power. The converter design is described with a particular attention to the crucial instances of switching and conduction losses and the thermal dissipation. Moreover the quasi-resonant operation mode has been exploited in order to improve the effectiveness of the solution adopted. The zero voltage operation is obtained by a gate driver chip specifically designed to build offline quasi-resonant zero voltage switching in flyback converters. Finally, several experimental tests are considered and specifically described
Towards controlled synthesis and better understanding of highly luminescent PbS/CdS core/shell quantum dots (2011)

A two-step cation exchange procedure has been developed for synthesizing PbS/CdS core/shell quantum dots (QDs) with a much thicker shell than previously reported, which expands the flexibility of the current cation exchange approach. The thick-shell QDs allow relatively easy observation of the core/shell morphology by transmission electron microscopy as well as exhibiting characteristic absorption and emission of CdS when the shell thickness reaches 1.8 nm. X-ray diffraction patterns show gradual transformation from a rock salt PbS pattern to a zinc blend CdS pattern with increasing shell thickness and the overall diffraction pattern is indeed the same as that of the CdS standard when the shell is thicker than 3.6 nm. The thick-shell QDs were further analyzed by energy dispersive X-ray spectrometry. It is found that Pb only exists in the core region and is essentially absent in the shell region. All of these results consistently suggest that the shell is made of CdS, instead of ternary PbxCd1−xS alloy in thick-shell QDs. As direct experimental identification of the shell composition in thin-shell QDs is difficult, experimental data and calculations are combined to indirectly probe this issue. The comparison of band gap versus core size plots of different compositional models indicates that it is highly likely that the thin shell is also made of CdS. Importantly, these core/shell PbS/CdS QDs not only show significantly increased quantum yield up to 67% at the optimal shell thickness of about 0.7 nm, they are also much more photostable and thermally stable than the shell-free PbS QDs.
Modello cinetico della polimerizzazione termoossidativa di un olio vegetale (1994)

Thermoxidation of a vegetable oil having an high degree of insaturation (Oenothera biennis L.) induces the lack of unsaturated fatty acids and determines the formation of a polymeric mass. To describe this process, involving the interaction among the different fatty acids, a kinetic model was hypothesized. The preliminary oxidation of an unsaturated fatty acid by the oxygen dissolved in the oil and the subsequent interaction of the activated compound with another insaturation to give a low reactive dimer, represent the two steps of the hypothesized model. The time evolution of fatty acid concentration was well described by a first order kinetics and the related kinetic constants were calculated
Larger Numbers of Glial and Neuronal Cells in the Periaqueductal Gray Matter of μ-Opioid Receptor Knockout Mice (2018)

<b>Background:</b> μ-opioid receptor knockout (MOP-KO) mice display baseline hyperalgesia. We have recently identified changes in tissue volume in the periaqueductal gray matter (PAG) using magnetic resonance imaging voxel-based morphometry. Changes in the structure and connectivity of this region might account for some behavior phenotypes in MOP-KO mice, including hyperalgesia. <b>Methods:</b> Adult male MOP-KO and wild-type (WT) mice were studied. Immunohistochemistry was performed to detect microglia, astrocytes, and neurons in the PAG using specific markers: ionized calcium-binding adaptor molecule 1 (Iba-1) for microglia, glial fibrillary acidic protein (GFAP) for astrocytes, and the neuronal nuclei antigen (NeuN; product of the Rbfox3 gene) for neurons, respectively. Cell counting was performed in the four parallel longitudinal columns of the PAG (dorsomedial, dorsolateral, lateral, and ventrolateral) at three different locations from bregma (-3.5, -4.0, and -4.5 mm). <b>Results:</b> The quantitative analysis showed larger numbers of well-distributed Iba1-IR cells (microglia), NeuN-IR cells (neurons), and GFAP-IR areas (astrocytes) at all the anatomically distinct regions examined, namely, the dorsomedial (DM) PAG, dorsolateral (DL) PAG, lateral (L) PAG, and ventrolateral (VL) PAG, in MOP-KO mice than in control mice. <b>Conclusions:</b> The cellular changes in the PAG identified in this paper may underlie aspects of the behavioral alterations produced by MOP receptor deletion, and suggest that alterations in the cellular structure of the PAG may contribute to hyperalgesic states.
Unidirectional cross-phosphorylation between the granulocyte colony-stimulating factor and interleukin 3 receptors. (1993)

The mouse interleukin-3 (IL-3)-dependent hemopoietic precursor cell line 32DC13 responds to granulocyte colony-stimulating factor (G-CSF) for proliferation and differentiation. We established a subline (32D-FH) of the 32DC13 cells which has lost the ability to respond to G-CSF. When murine G-CSF receptor cDNA was introduced into the 32D-FH cell line, the transformants responded to G-CSF as well as to IL-3 for proliferation. Adding G-CSF to the transformants rapidly induced tyrosine phosphorylation not only of the G-CSF receptor but also of both subtypes of the IL-3 receptor beta-chain (AIC2A and AIC2B molecules). On the other hand, stimulation of the transformants with IL-3 induced tyrosine phosphorylation of the AIC2A and AIC2B but not of the G-CSF receptor. These results indicate that the tyrosine kinase activated through the G-CSF receptor interacts with the IL-3 receptor beta-chains but not vice versa. This unidirectional cross-phosphorylation between the G-CSF and IL-3 receptors may play a role in granulopoiesis induced by G-CSF.
Growth mechanism of nanowires: binary and ternary chalcogenides (2016)

Semiconductor nanowires exhibit very exciting optical and electrical properties including high transparency and a several order of magnitude better photocurrent than thin film and bulk materials. We present here the mechanism of nanowire growth from the melt-liquid-vapor medium. We describe preliminary results of binary and ternary selenide materials in light of recent theories. Experiments were performed with lead selenide and thallium arsenic selenide systems which are multifunctional material and have been used for detectors, acoustooptical, nonlinear and radiation detection applications. We observed that small units of nanocubes and elongated nanoparticles arrange and rearrange at moderate melt undercooling to form the building block of a nanowire. Since we avoided the catalyst, we observed self-nucleation and uncontrolled growth of wires from different places. Growth of lead selenide nanowires was performed by physical vapor transport method and thallium arsenic selenide nanowire by vapor-liquid-solid (VLS) method. In some cases very long wires (&gt;mm) are formed. To achieve this goal experiments were performed to create situation where nanowires grew on the surface of solid thallium arsenic selenide itself.
Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas (2006)

Integrative genomic and gene-expression analyses have identified amplified oncogenes in B-cell non-Hodgkin lymphoma (B-NHL), but the capability of such technologies to localize tumor suppressor genes within homozygous deletions remains unexplored. Array-based comparative genomic hybridization (CGH) and gene-expression microarray analysis of 48 cell lines derived from patients with different B-NHLs delineated 20 homozygous deletions at 7 chromosome areas, all of which contained tumor suppressor gene targets. Further investigation revealed that only a fraction of primary biopsies presented inactivation of these genes by point mutation or intragenic deletion, but instead some of them were frequently silenced by epigenetic mechanisms. Notably, the pattern of genetic and epigenetic inactivation differed among B-NHL subtypes. Thus, the P53-inducible PIG7/LITAF was silenced by homozygous deletion in primary mediastinal B-cell lymphoma and by promoter hypermethylation in germinal center lymphoma, the proapoptotic BIM gene presented homozygous deletion in mantle cell lymphoma and promoter hypermethylation in Burkitt lymphoma, the proapoptotic BH3-only NOXA was mutated and preferentially silenced in diffuse large B-cell lymphoma, and INK4c/P18 was silenced by biallelic mutation in mantle-cell lymphoma. Our microarray strategy has identified novel candidate tumor suppressor genes inactivated by genetic and epigenetic mechanisms that substantially vary among the B-NHL subtypes.
Monthly hemostatic factor variability in women and men (2020)

Hormonal status influences hemostatic factors including fibrinogen, factor VII and plasminogen activator inhibitor (PAI-1), and concentrations differ among men, premenopausal and postmenopausal women. This study examines how phases of the menstrual cycle influence variability of fibrinogen, factor VII and PAI-1.
Educating for Social Responsibility: The Effectiveness and Ethics of a Community Service Project with Persons with Disabilities (1993)

Developing a sense of social responsibility in students is a mandate for educators in recreation and leisure services. One way to foster social responsibility is to involve students in community service projects, where the effects of their actions on others are direct and meaningful. But involvement in community service also introduces ethical issues into the curriculum and into the lives of the people being served in the community service project. This study attempted to investigate the effectiveness of a community service project with persons with disabilities to foster social responsibility in university students and to explore the ethical issues in doing so. The results showed that community service involvement was an effective method of raising awareness of the concerns of inclusion of persons with disabilities in community leisure services and fostering genuine caring and respect. The results also raised issues in terms of relationship development and termination with persons with disabilities.
Isabelle Real, Vies de saints, vie de famille. Représentation et système de la parenté dans le Royaume mérovingien (481-751) d'après les sources hagiographiques (2002)

Lett Didier. Isabelle Real, Vies de saints, vie de famille. Représentation et système de la parenté dans le Royaume mérovingien (481-751) d'après les sources hagiographiques. In: Médiévales, n°43, 2002. Le bain : espaces et pratiques, sous la direction de Didier Boisseuil . pp. 174-176.
Halogen Bonding in Perovskite Solar Cells: A New Tool for Improving Solar Energy Conversion (2021)

Hybrid organic-inorganic halide perovskites (HOIHPs) have recently emerged as a flourishing area of research. Their easy and low-cost production and their unique optoelectronic properties make them promising materials for many applications. In particular, HOIHPs hold great potential for next-generation solar cells. However, their practical implementation is still hindered by their poor stability in air and moisture, which is responsible for their short lifetime. Optimizing the chemical composition of materials and exploiting non-covalent interactions for interfacial and defects engineering, as well as defect passivation, are efficient routes towards enhancing the overall efficiency and stability of perovskite solar cells (PSCs). Due to the rich halogen chemistry of HOIHPs, exploiting halogen bonding, in particular, may pave the way towards the development of highly stable PSCs. Improved crystallization and stability, reduction of the surface trap states, and the possibility of forming ordered structures have already been preliminarily demonstrated.
Neural network-based decision feedback equalizer using a recursive least squares algorithm (2006)

In this work, a recently derived recursive least-square (RLS) algorithm to train multi layer perceptron (MLP) is used for a decision feedback equalization (DFE) scenario. Its performance is investigated and compared to those of MLPDFE based on the back propagation (BP) algorithm and the simple DFE based on the least-mean square (LMS) algorithm. The results show improved performance obtained by the new structure in both time-invariant and time-varying fading channels.
Extended retreatment with brentuximab vedotin (SGN-35) maintains complete remission in patient with recurrent systemic anaplastic large-cell lymphoma (2011)

"Extended retreatment with brentuximab vedotin (SGN-35) maintains complete remission in patient with recurrent systemic anaplastic large-cell lymphoma." Leukemia & Lymphoma, 53(3), pp. 506–507
Cross-reactivity between sera from dogs experimentally infected with Dirofilaria immitis and crude extract of Toxocara canis (2002)

This study was performed to investigate whethere there is cross-reactivity between Dirofilaria immitis and three intestinal nematodes of dogs. In ELISA, D. immitis-infected dog sera obtained at the 4th molting stage (9-11 weeks) and microfilaremic stage (25-30 weeks) were shown to be highly reactive with crude extract of T. canis. In immunoblotting, some antigenic fractions, 44, 57, 88, 100 kDa of crude extract of T. canis, were found to be positive reaction with sera of dogs infected with D. immitis. However, little or no cross-reaction were observed between sera of D. immitis-infected dogs and crude extract antigen of T. vulpis or A. caninum. These result suggest that there are partial cross reaction between sera of D. immitis-infected dogs and the antigen of T. canis.
Enhancement of photoresponsive electrical charac- teristics of multilayer MoS 2 transistors using rubrene patches (2015)

Multilayer MoS2 is a promising active material for sensing, energy harvesting, and optoelectronic devices owing to its intriguing tunable electronic band structure. However, its optoelectronic applications have been limited due to its indirect band gap nature. In this study, we fabricated a new type of phototransistor using multilayer MoS2 crystal hybridized with p-type organic semiconducting rubrene patches. Owing to the outstanding photophysical properties of rubrene, the device characteristics such as charge mobility and photoresponsivity were considerably enhanced to an extent depending on the thickness of the rubrene patches. The enhanced photoresponsive conductance was analyzed in terms of the charge transfer doping effect, validated by the results of the nanoscale laser confocal microscope photoluminescence (PL) and time-resolved PL measurements.
Another one in the chamber: cabozantinib for patients with metastatic non clear cell renal cell carcinoma (2019)

The term ‘’Non-clear cell Renal Cell Carcinoma (nccRCC)’’ recognized a large series of renal tumours characterized of a specific genomic and morphological signature. Compared to clear cell renal cell carcinoma (ccRCC), these tumours are uncommon diagnoses with an overall incidence around 20–25% of primary kidney tumours) (1).
Bias dependent performance of 1.55 μm absorption high-speed n-i-n photodetectors using low-temperature grown GaAs (2003)

We have successfully fabricated a novel n-i-n photodetector operating at 1.55 /spl mu/m on GaAs. The characteristics at high-speed (above 20 GHz) and the high efficiency at high bias show that this kind of photodetector has potential application in the fields of long-wavelength optical-fiber communication and for integration with GaAs integrated circuits.
SARS-CoV-2 infection damages airway motile cilia and impairs mucociliary clearance (2020)

ABSTRACT Understanding how SARS-CoV-2 spreads within the respiratory tract is important to define the parameters controlling the severity of COVID-19. We examined the functional and structural consequences of SARS-CoV-2 infection in a reconstituted human bronchial epithelium model. SARS-CoV-2 replication caused a transient decrease in epithelial barrier function and disruption of tight junctions, though viral particle crossing remained limited. Rather, SARS-CoV-2 replication led to a rapid loss of the ciliary layer, characterized at the ultrastructural level by axoneme loss and misorientation of remaining basal bodies. The motile cilia function was compromised, as measured in a mucociliary clearance assay. Epithelial defense mechanisms, including basal cell mobilization and interferon-lambda induction, ramped up only after the initiation of cilia damage. Analysis of SARS-CoV-2 infection in Syrian hamsters further demonstrated the loss of motile cilia in vivo . This study identifies cilia damage as a pathogenic mechanism that could facilitate SARS-CoV-2 spread to the deeper lung parenchyma.
Apomorphine-Induced Stereotyped Biting in the Tortoise in Relation to Dopaminergic Mechanisms (1975)

A biting behavior in the Moroccan pond tortoise (Clemmys caspica leprósa) after apomorphine administration is described. The biting behavior was antagonized by the specific anti-dopaminergic drug haloperidol (10 mg/kg) and trifluperazine (15 mg/kg). The behavior was compared to similar behaviors in birds and mammals. The dopamine metabolites, homovanillic acid and 3,4-dihydroxyphenylacetic acid, were measured by a gas chromatographic method in the tortoise brain. From the effects on behavior and the changes in the level of these metabolites upon drug administration it was concluded that the dopamine system in the tortoise is qualitatively similar to that in birds and mammals but less sensitive to blockade.