gebhart/patrepeval huggingface dataset:
A high-speed hyperspectral laparoscopic imaging system (2023)

Minimally invasive surgery (MIS) has expanded broadly in the field of abdominal and pelvic surgery. Laparoscopic and robotic surgery has improved surgeon ergonomics, instrument precision, operative time, and postoperative recovery across various abdominal procedures. The goal of this study is to establish the feasibility of implementing high-speed hyperspectral imaging into a standard laparoscopic setup and exploring its benefit to common intracorporeal procedures. A hyperspectral laparoscopic imaging system was constructed using a customized hyperspectral camera alongside a standard rigid laparoscope and was validated for both spectral and spatial accuracy. Demosaicing methods were investigated for improved full-resolution visualization. Hyperspectral cameras with different spectral ranges were considered and compared with one another alongside two different light sources to determine the most effective configuration. Finally, different porcine tissues were imaged <i>ex-vivo</i> to test the capabilities of the system and spectral footprints of the various tissues were extracted. The tissue was also imaged in a phantom to simulate the system's use in MIS. The results demonstrated a hyperspectral laparoscopic imaging system that could provide quantitative, diagnostic information while not disrupting normal workflow nor adding excessive weight to the laparoscopic setup. The high-speed hyperspectral laparoscopic imaging system can have immediate applications in image-guided surgery.
Peptide Mapping by Two-Dimensional Thin-Layer Electrophoresis-Thin-Layer Chromatography (2009)

The principle behind peptide mapping is straightforward: If two proteins have the same primary structures, then cleavage of each protein with a specific protease or chemical cleavage reagent will yield identical peptide fragments. However, if the proteins have different primary structures, and then the cleavage will generate unrelated peptides. The similarity or dissimilarity of the proteins’ primary structure is reflected in the similarity or dissimilarity of the peptide fragments. Separation of peptides by 2-D thin-layer electrophoresis—thin-layer chromatography (2-D TLE-TLC) results in very high resolution of the peptides, making subtle comparisons possible.
High Level of Tobacco Carcinogen–Derived DNA Damage in Oral Cells Is an Independent Predictor of Oral/Head and Neck Cancer Risk in Smokers (2017)

Exposure to tobacco-specific nitrosamines (TSNA) and polycyclic aromatic hydrocarbons (PAH) is recognized to play an important role in the development of oral/head and neck squamous cell cancer (HNSCC). We recently reported higher levels of TSNA-associated DNA adducts in the oral cells of smokers with HNSCC as compared with cancer-free smokers. In this study, we further investigated the tobacco constituent exposures in the same smokers to better understand the potential causes for the elevated oral DNA damage in smokers with HNSCC. Subjects included cigarette smokers with HNSCC (cases, <i>n</i> = 30) and cancer-free smokers (controls, <i>n</i> = 35). At recruitment, tobacco/alcohol use questionnaires were completed, and urine and oral cell samples were obtained. Analysis of urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and <i>N</i>'-Nitrosonornicotine (NNN; TSNA biomarkers), 1-hydroxypyrene (1-HOP, a PAH), cotinine, 3'-hydroxycotinine, and the nicotine metabolite ratio (NMR) were performed. Cases and controls differed in mean age, male preponderance, and frequency of alcohol consumption (but not total alcoholic drinks). Univariate analysis revealed similar levels of NNN, 1-HOP, and cotinine between groups but, as reported previously, significantly higher DNA adduct formation in the cases. Multiple regression adjusting for potential confounders showed persistent significant difference in DNA adduct levels between cases and controls [ratio of geometric means, 20.0; 95% CI, 2.7-148.6). Our cohort of smokers with HNSCC demonstrates higher levels of TSNA-derived oral DNA damage in the setting of similar exposure to nicotine and tobacco carcinogens. Among smokers, DNA adduct formation may act as a predictor of eventual development of HNSCC that is independent of carcinogen exposure indicators. <i>Cancer Prev Res; 10(9); 507-13. ©2017 AACR</i><i>See related editorial by Johnson and Bauman, p. 489</i>.
Phase continuity and inversion in polymer blends and simultaneous interpenetrating networks (1986)

Abstract A semi‐empirical expression for predicting phase continuity and inversion in polymer blends and simultaneous interpenetrating networks (SINs) was developed and examined experimentally. A rheological model based on the volume fraction, ϕ, and viscosity, η, led to the equation as the criteria for dual phase continuity for phases 1 and 2. This relation was evaluated for two systems: a castor oil polyester‐urethane/polystyrene SIN, and a mechanical blend of polystyrene and polybutadiene. Literature data was also examined. A gradual phase inversion was found, with a region of dual phase continuity in between. While predictions of phase continuity were confirmed for the mechanical blends, they were not confirmed for the SIN system. This was probably due to rapid gelation at the point of phase inversion.
Managing aircraft lifecycle complexity (2016)

A thorough analysis of data on aircraft lifecycle revealed inadequacy of current lifecycle management methods in the face of increased complexity of the Internet-based global market. A new method for managing lifecycle has been developed by authors and their teams using concepts and principles of the emerging complexity science with the aim of reducing lead times and costs. Centralised control has been replaced with distributed decision-making empowering all lifecycle stakeholders. The solution described in this paper is the first of its kind and it represents a genuine advance in knowledge, which leads to considerable reduction in design/production lead times and decrease in the lifecycle cost. The method has been validated in a variety of applications.
82‐5: Late-News Paper: High‐Resolution Printing for Future Processing of RGB OLED Displays (2018)

High resolution ESJET printing is presented for processing of OLED devices. With appropriate nozzle geometry and driving schemes pixel structures of 10 µm and below are achievable with the final goal of printing a 310 ppi RGB AMOLED display.
TREATMENT WITH EXENATIDE PRESERVES BETA CELL MASS IN HUMAN ISLETS DURING CULTURE: IMPLICATIONS FOR ISLET TRANSPLANTATION (2010)

Marzban, L.; Ao, Z.; Kieffer, T. J.; Meloche, M.; Safikhan, N.; Thompson, D.; Warnock, G. L. Author Information
Total Synthesis of (±)‐Scopolamine: Challenges of the Tropane Ring (2016)

Abstract Scopolamine was synthesized using 6,7‐dehydrotropine as a key intermediate. Rhodium‐catalyzed [4 + 3] cycloaddition chemistry and a modified Robinson–Schöpf reaction were each independently evaluated for their utility in constructing the tropane core. Both synthetic approaches gave comparable overall yields.
On Broadcast Authentication in Wireless Sensor Networks (2007)

Broadcast authentication is a critical security service in wireless sensor networks (WSNs), since it enables users to broadcast the WSN in an authenticated way. Symmetric key based schemes such as muTESLA and multilevel muTESLA have been proposed to provide such services for WSNs; however, these schemes all suffer from serious DoS attacks due to the delay in message authentication. This paper presents several effective public key based schemes to achieve immediate broadcast authentication and thus overcome the vulnerability presented in the muTESLA-like schemes. Several cryptographic techniques, including Merkle hash tree and identity-based signature scheme, are adopted to minimize the scheme overhead regarding the costs on both computation and communication. A quantitative energy consumption analysis of the proposed schemes is given in detail. We believe that this paper can serve as the start point towards fully solving the important multisender broadcast authentication problem in WSNs.
Data from AXL and Error-Prone DNA Replication Confer Drug Resistance and Offer Strategies to Treat EGFR-Mutant Lung Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;Anticancer therapies have been limited by the emergence of mutations and other adaptations. In bacteria, antibiotics activate the SOS response, which mobilizes error-prone factors that allow for continuous replication at the cost of mutagenesis. We investigated whether the treatment of lung cancer with EGFR inhibitors (EGFRi) similarly engages hypermutators. In cycling drug-tolerant persister (DTP) cells and in EGFRi-treated patients presenting residual disease, we observed upregulation of GAS6, whereas ablation of GAS6's receptor, AXL, eradicated resistance. Reciprocally, AXL overexpression enhanced DTP survival and accelerated the emergence of T790M, an EGFR mutation typical to resistant cells. Mechanistically, AXL induces low-fidelity DNA polymerases and activates their organizer, RAD18, by promoting neddylation. Metabolomics uncovered another hypermutator, AXL-driven activation of MYC, and increased purine synthesis that is unbalanced by pyrimidines. Aligning anti-AXL combination treatments with the transition from DTPs to resistant cells cured patient-derived xenografts. Hence, similar to bacteria, tumors tolerate therapy by engaging pharmacologically targetable endogenous mutators.&lt;/p&gt;Significance:&lt;p&gt;EGFR-mutant lung cancers treated with kinase inhibitors often evolve resistance due to secondary mutations. We report that in similarity to the bacterial SOS response stimulated by antibiotics, endogenous mutators are activated in drug-treated cells, and this heralds tolerance. Blocking the process prevented resistance in xenograft models, which offers new treatment strategies.&lt;/p&gt;&lt;p&gt;&lt;i&gt;&lt;a href="https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-12-11-ITI" target="_blank"&gt;This article is highlighted in the In This Issue feature, p. 2483&lt;/a&gt;&lt;/i&gt;&lt;/p&gt;&lt;/div&gt;
Continuous Monitoring and Characterization of Copolymerization Reactions of Acrylate Monomers with Indistinguishable Ultraviolet Spectra Using Infrared Spectroscopy (2022)

Abstract Applications of Automatic Continuous Online Monitoring of Polymerization reactions (ACOMP) have steadily expanded over the past 20 years. An ultraviolet (UV) detector, often combined with a differential refractive index detector (RID), is the usual method to track monomer conversion, but the method can fail when comonomers have similar UV spectra. Here, Fourier‐transform infrared spectroscopy (FTIR) is coupled to ACOMP to separate comonomer conversion during solution copolymerization of tert‐butyl acrylate (tBA) and n‐butyl acrylate (nBA). The UV spectra of these comonomers are too similar for separation. The FTIR region between 1100 and 1410 cm −1 , however, shows a strong difference between tBA and nBA peaks—1403 and 1192 cm −1 , respectively. Reaction rates determined from FTIR data show that tBA's is higher than nBA's. The terpolymerization of tBA, nBA, and methyl methacrylate (MMA) is also monitored, using MMA's 1325 cm −1 peak. Reaction rates are significantly lower than in the nBA/tBA copolymerization. The incorporation of FTIR into ACOMP opens the path for further expansion to a wide variety of copolymerization reactions, including systems of three or more comonomers. It can be a key new detector in the next steps for development of fully automatic feedback control of composition and molecular weight.
Analysis of prognostic factors of pediatric-type sarcomas in adult patients. (2010)

10094 Background: Pediatric-type sarcomas such as Ewing's sarcoma/primitive neuroectodermal tumor family (EWS/PNET) and rhabdomyosracoma (RMS) are relatively uncommon in adult patients (pts). Optimal treatment strategies for this population remain controversial and there have been debates on whether adults do worse than pediatric pts with the same stage of disease. Methods: To identify prognostic factors, we retrospectively reviewed clinical data on pts with pediatric type sarcoma older than 15 years at a single institution. Results: Seventy-five consecutive patients from February 1995 to October 2005 were identified from the database at the Samsung Medical Center, Seoul, Korea. Forty-five patients (60.0%) of 75 patients were male. Median age of patients was 30-year old with range of 15–74. Forty patients (53.3%) were diagnosed as EWS/PNET, 32 patients (42.7%) as RMS and 3 patients (3%) as DSRCT. Median overall survival (OS) for all patients was 39 months (95% CI. 13.0-65.0 months) and median event-free survival (EFS) for all patients was 19 months (95% CI. 5.0-33.0). Multivariate analysis revealed that age over 30, IRS III/IV and poor performance status were significant independent prognostic factors for poor OS, whereas IRS III/IV was the only prognostic factors for EFS. In subset analysis, only pts younger than 30 years showed favorable outcomes in pts group with IRS I/II. Conclusions: Although the limits of this retrospective study are self-evident, we identified the prognostic variables enable risk-adapted therapies for this rare adult sarcoma group, which should be further investigated. Also, our data would suggest that pediatric treatment protocols are feasible for the adult pts so optimal therapy should be given to the pts. No significant financial relationships to disclose.
A generalizable method for estimating duration of HIV infections using clinical testing history and HIV test results (2019)

The new 'two-step' method more accurately estimates timing of infection and is intended to be generalizable to more situations in clinical medicine, research, and surveillance than previous methods. An online tool is now available that enables researchers/clinicians to input data related to method 4, and generate estimated dates of detectable infection.
Frequency noise of amplifier-similariton laser combs (2013)

Measurements of the free running carrier envelope offset frequency (fceo) linewidth of a similariton based optical frequency comb show that the frequency noise of the laser is independent of net cavity dispersion.
CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma (2020)

These studies identify lncGRS-1 as a glioma-specific therapeutic target and establish a generalizable approach to rapidly identify novel therapeutic targets in the vast non-coding genome to enhance radiation therapy.
Image de-blurring of PROPELLER EPI using a k-space weighting scheme (2006)

T-C. Chuang, T-Y. Huang, F-N. Wang, F-H. Lin, C-W. Ko, C-Y. Chen, H-W. Chung, K. K. Kwong E.E., National Taiwan University, Taipei, Taiwan, Taiwan, E.E., National Taiwan University of Science and Technology, Taipei, Taiwan, Taiwan, MGH-HMS-MIT Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, United States, Computer Science and Engineering, National Sun Yat-Sen University, Kaohsiung, Taiwan, Taiwan, Radiology, Tri-Service General Hospital, Taipei, Taiwan, Taiwan Introduction The multi-shot PROPELLER-EPI technique has been shown to be an effective method for high-resolution diffusion tensor imaging (1). Since each rotating blade of k-space data is acquired by single-shot spin-echo EPI, susceptibility-induced off-resonance effects could lead to geometric distortions along the phase-encoding direction (2). A combination of these rotating data blades thus results in blurring in the final PROPELLER-EPI images. One method to reduce the blurring effect is to use triangular windowing, which weighs the k-space data according to the timing distance from the center of the spin-echo in a monotonically decreasing manner. (2) Since the off-resonance effects increase as the departing time from the spin-echo increases, the weighting operation reduces the contributions of data that are less reliable. In this work, we further compare the effects on blurring and signal-to-noise ratio (SNR) using exponential windowing functions at different decaying time constants.
Comparison of Weight Loss Among Named Diet Programs in Overweight and Obese Adults (2014)

Significant weight loss was observed with any low-carbohydrate or low-fat diet. Weight loss differences between individual named diets were small. This supports the practice of recommending any diet that a patient will adhere to in order to lose weight.
ChemInform Abstract: Hauser—Kraus Annulation of Phthalides with Nitroalkenes for the Synthesis of Fused and Spiro Heterocycles. (2016)

Abstract A Hauser—Kraus annulation of sulfonylphthalides with conjugated nitro alkenes furnishes naphthoquinones in moderate yields.
Giant cell tumor in a case of Paget's disease of bone: an aggressive benign tumor exhibiting a quick response to an innovative therapeutic agent. (2010)

Giant cell tumor of bone, also called osteoclastoma, is a rare skeletal complication of Paget's disease of bone. We here report a patient from Southern Italy who developed a GCT infiltrating the neighboring tissues. We will focus on either a review on this rare bone tumor, including some genetic aspects, or the current established therapies. Since this case has been published in International literature, here we report the updated clinical findings on it. Finally, we will describe the therapeutic outcomes of this unique complication of Paget's disease of bone as a rapid response to an innovative therapeutic agent.
Evolutionary site-number changes of ribosomal DNA loci during speciation: complex scenarios of ancestral and more recent polyploid events (2015)

Several genome duplications have been identified in the evolution of seed plants, providing unique systems for studying karyological processes promoting diversification and speciation. Knowledge about the number of ribosomal DNA (rDNA) loci, together with their chromosomal distribution and structure, provides clues about organismal and molecular evolution at various phylogenetic levels. In this work, we aim to elucidate the evolutionary dynamics of karyological and rDNA site-number variation in all known taxa of subtribe Vellinae, showing a complex scenario of ancestral and more recent polyploid events. Specifically, we aim to infer the ancestral chromosome numbers and patterns of chromosome number variation, assess patterns of variation of both 45S and 5S rDNA families, trends in site-number change of rDNA loci within homoploid and polyploid series, and reconstruct the evolutionary history of rDNA site number using a phylogenetic hypothesis as a framework. The best-fitting model of chromosome number evolution with a high likelihood score suggests that the Vellinae core showing x = 17 chromosomes arose by duplication events from a recent x = 8 ancestor. Our survey suggests more complex patterns of polyploid evolution than previously noted for Vellinae. High polyploidization events (6x, 8x) arose independently in the basal clade Vella castrilensis-V. lucentina, where extant diploid species are unknown. Reconstruction of ancestral rDNA states in Vellinae supports the inference that the ancestral number of loci in the subtribe was two for each multigene family, suggesting that an overall tendency towards a net loss of 5S rDNA loci occurred during the splitting of Vellinae ancestors from the remaining Brassiceae lineages. A contrasting pattern for rDNA site change in both paleopolyploid and neopolyploid species was linked to diversification of Vellinae lineages. This suggests dynamic and independent changes in rDNA site number during speciation processes and a significant lack of correlation between 45S and 5S rDNA evolutionary pathways.
Evaluation of trichloroethylene degradation by starch supported Fe/Ni nanoparticles via response surface methodology (2015)

In this study, degradation of trichloroethylene (TCE), a chlorinated hydrocarbon, using starch supported Fe/Ni nanoparticles was investigated. The scanning electron microscope images showed applying water soluble starch as a stabilizer for the Fe/Ni nanoparticles tended to reduce agglomeration and discrete particle. Also the mean particle diameter reduced from about 70 nm (unsupported Fe/Ni nanoparticle) to about 30 nm. Effects of three key independent operating parameters including initial TCE concentration (10.0-300.0 mg L(-1)), initial pH (4.00-10.00) and Fe(0) dosage (0.10-2.00) g L(-1) on TCE dechlorination efficiency in 1 hour were analysed by employing response surface methodology (RSM). Based on a five-level three-factor central composite design, TCE removal efficiency was examined and optimized. The obtained RSM model fitted the experimental data to a second order polynomial equation. The optimum dechlorination conditions at initial TCE concentration 100.0 mg L(-1) were initial pH 5.77, Fe(0) dosage 1.67 g L(-1). At these conditions TCE removal concentration reached 94.87%, which is in close acceptance with predicted value by the RSM model.
Making chicken pox prevention a priority. (2004)

School nurses are the IDEAL professionals to catch those kids without a history of chicken pox (varicella illness) who have not been immunized, thereby falling into the susceptible range. We handle charts daily. We have both illness history (if it was provided) and immunization dates. We can call parents. We can talk to kids. Wouldn't it be easy if we could do that and then call (or email) the primary care provider? But there is no longer an "easy" way to communicate health information. Doing things the easy way could be perceived by some as "tattling" and by others as "reporting without permission." Instead, the school nurse must take the time-consuming (and better long range) path of education ... of the student, and the parent. And the priority can slip down below other school nurse requirements such as getting kids their required immunizations, first aid and illness care, individualized health care plans for students with medical problems, parent and teacher phone calls, and endless conversations. It takes a village to raise a child though, and the school nurse is a village resident. The following information is vital to the knowledge base of today's school nurse. Please read it, store it and consider it when planning and intervening with your students in the day-to-day interaction that promotes optimal health and wellness.
Software engineering education (SEEd) (2004)

article Share on Software engineering education (SEEd) Author: Peter B. Henderson Butler University, Indianapolis, Indiana Butler University, Indianapolis, IndianaView Profile Authors Info & Claims ACM SIGSOFT Software Engineering NotesVolume 29Issue 2March 2004 pp 6–8https://doi.org/10.1145/979743.979747Online:01 March 2004Publication History 2citation509DownloadsMetricsTotal Citations2Total Downloads509Last 12 Months0Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access