gebhart/patrepeval huggingface dataset:
The Preparation of Two Aromatic Analogs of Desoxycorticosterone Acetate (1949)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Preparation of Two Aromatic Analogs of Desoxycorticosterone AcetateCarl. Djerassi and Caesar R. ScholzCite this: J. Am. Chem. Soc. 1949, 71, 12, 3962–3966Publication Date (Print):December 1, 1949Publication History Published online1 May 2002Published inissue 1 December 1949https://doi.org/10.1021/ja01180a022Request reuse permissionsArticle Views85Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (578 KB) Get e-Alertsclose Get e-Alerts
Terminology for use of parts outside manufacturer-specified temperature ranges (1999)

The use of the definitions described in this article related to the use of semiconductor parts outside manufacturer-specified temperature range represents a consensus among various sectors of the electronics industry. The use of these terms and definitions will improve the understanding of the issues involved, facilitate communication across the supply chain, and provide legal clarity.
Index to Volume 88 (1998)

Other| December 01, 1998 Index to Volume 88 Michael Fehler; Michael Fehler Search for other works by this author on: GSW Google Scholar Susanna Alde Susanna Alde Search for other works by this author on: GSW Google Scholar Bulletin of the Seismological Society of America (1998) 88 (6): 1589–1611. https://doi.org/10.1785/BSSA0880061589 Article history first online: 03 Mar 2017 Cite View This Citation Add to Citation Manager Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Search Site Citation Michael Fehler, Susanna Alde; Index to Volume 88. Bulletin of the Seismological Society of America 1998;; 88 (6): 1589–1611. doi: https://doi.org/10.1785/BSSA0880061589 Download citation file: Ris (Zotero) Refmanager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search nav search search input Search input auto suggest search filter All ContentBy SocietyBulletin of the Seismological Society of America Search Advanced Search This content is PDF only. Please click on the PDF icon to access. First Page Preview Close Modal You do not currently have access to this article.
Adsorbate–adsorbate repulsions—the coverage dependence of the adsorption structure of CO on Cu(110) as studied by electron-stimulated desorption ion angular distribution (1996)

The coverage dependent orientation of CO adsorbed on a Cu(110) surface was studied by the electron-stimulated desorption ion angular distribution (ESDIAD) technique. A neutral excited (CO*) species is imaged and in addition positive ions are measured. The adsorption temperature was varied between 32 K and 150 K. By applying the ESDIAD technique at a temperature below 80 K it was possible to decrease the beamwidths drastically, to determine the angular distributions better than ±0.5°, and to study the adsorption of CO chemisorbed and physisorbed on the surface. With increasing CO coverage we observe three distinct ESDIAD patterns. Starting from a normal beam pattern with an elliptical cross section with the major axis oriented in the 〈11̄0〉 direction for coverages up to 0.2 monolayer (ML), a transformation of the ESDIAD pattern into a pattern of two separated beams is observed for a coverage of about 0.5 ML, indicating a tilting of the molecules in the 〈11̄0〉 directions by ∼9°. With further increasing CO coverage an additional central peak develops with an elliptical broadening now in the 〈001〉 direction. The changes of the pattern are reversible as shown by decreasing the coverage by thermal desorption. Based on these ESDIAD and digital low energy electron diffraction results, a linear-chain model for CO adsorption is proposed. Temperature programmed desorption measurements also indicate the presence of repulsive CO–CO interactions in the adlayer.
Integrated Optical Pulse Shaping: SOA Amplitude Control and Sub-microsecond Switching of 32 Channels at 25 GHz Spacing (2016)

Get PDF Email Share Share with Facebook Share on X Post on reddit Share with LinkedIn Add to Mendeley Add to BibSonomy Share with WeChat Get Citation Copy Citation Text A. J. Metcalf, D. E. Leaird, J. A. Jaramillo-Villegas, V. Lal, A. Hosseini, G. E. Hoefler, F. Kish, and A. M. Weiner, "Integrated Optical Pulse Shaping: SOA Amplitude Control and Sub-microsecond Switching of 32 Channels at 25 GHz Spacing," in Conference on Lasers and Electro-Optics, OSA Technical Digest (2016) (Optica Publishing Group, 2016), paper SM4I.6. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
The Role and Mechanism of CRT0066101 as an Effective Drug for Treatment of Triple-Negative Breast Cancer (2019)

PRKD inhibitor CRT0066101 exhibits anti-TNBC effects via modulating a phosphor-signaling network and inhibiting the phosphorylation of many cancer-driving factors, including MYC, MAPK1/3, AKT, YAP, and CDC2, providing insight into the important roles as well as the molecular mechanism of CRT0066101 as an effective drug for TNBC.
Introduction to imec's AttoLab for ultrafast kinetics of EUV exposure processes and ultra-small pitch lithography (2021)

Imec’s AttoLab is the first industrial laboratory capable of watching the ultrafast dynamics of photoresists following 13.5 nm, EUV exposure, and for emulating high-numerical-aperture (high-NA) exposure on 300-mm wafers using two-beam EUV interference. The two respective beamlines are powered by a laser-based high-harmonic generation EUV source. Its capabilities have recently been proven by imaging 20 nm pitch lines and spaces using Lloyd’s Mirror interference lithography. In parallel, time-averaged and time-resolved techniques for studying the ultrafast dynamics of photoresists after EUV exposure, coherent diffractive imaging to study resist interfaces, and more sophisticated interference lithography techniques for printing sub-22 nm pitches on full 300-mm wafers are being developed. Taking advantage of the bright and short EUV pulses now available at imec, we will be able to contribute to a smooth transition towards next generation high-NA lithography.
Damage mechanisms and characteristics of the cavity reflectors for vacuum ultraviolet argon excimer lasers. (1990)

For high-power outputs from rare-gas excimer lasers, cavity reflectors having high reflectivity and free from radiation damage areprimarily required. We measure reflectivities and surface topographic features for some reflectors made of Alfilms deposited on SiO2 substrates, SiC films deposited on graphite substrates, SiO2 glasses, and single crystals of W, Mo, Si and Cr. The results of surface damageobserved on Al and Si mirrors as well as a thermodynamical calculation show that the surface damage is caused mainly by surfacemelting due to strong absorption of laser energy.
Domain engineering in LiTaO<inf>3</inf> by focused charge beam: From micro to nano scale (2006)

In this study, 1-μm-dot domain by resist-assisted electron beam writing and 100-nm-wide line domain by focused ion beam domain patterning techniques have been demonstrated in LiNbO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> and LiTaO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> crystals thicker than tens of μm.
Pharmacology of Antimuscarinic Agents (1997)

Introduction History Nomenclature Mechanism and Site of Action of Antimuscarinic Agents Description and Classification of Acetylcholinergic Receptor Sites The Role of ACh in Neuronal Conduction Chemical Structural Aspects Related to Stimulation and Block of the ACh Receptors The Tropane Alkaloids Chemistry Absorption, Distribution, Metabolism, and Elimination of Atropine and Related Tropane Alkaloids (Animal and Human Data) Animal Pharmacology of Atropine Resistance to Atropine Hyosciamine L (-) Hyoscine (Scopolamine) - Introduction Atropine and L (-) Hyoscine as Pharmacologic Probes in the Pharmacologic Exploration of the CNS Semisynthetic Derivatives of Tropane Alkaloids and Other Tropine Esters N-Methylquaternary Derivatives of Tropane Alkaloids - Introduction Other Tropeines Synthetic Antimuscarinic Agents Antimuscarinic Tropane Derivatives Other Bicyclic and Polycyclic Amines 4-Acyloxy 2,6-Disubstituted Piperidines Aliphatic and Alicyclic Aminoalcohol Esters of Aromatics Acids 1,3-Dioxolane Derivatives Amino Alkanols and Amino Alkanes Substituted with Aromatic Groups Aromatic Acid Amide and Nitrile Derivatives of Alkyl Amines Aromatic Ether Derivatives of Amino Alkanols Other Compounds of Various Chemical Structures with Antimuscarinic Properties Synthetic Agents with Central Acetylcholinolytic Properties Used in Parkinson's Disease Molecular Design of Antimuscarinic Agents Muscarinic Receptor Subtype-Nonspecific Agents Muscarinic Receptor Subtype-Specific Agents Drug Interactions Clinical Pharmacology and Therapeutic Uses of Antimuscarinic Agents Pharmacokinetics Effects on the Cardiovascular System in Man Effects on Respiration Effects on the Motor Functions of the Gastrointestinal and Genitourinary Tract Action on Secretory Functions Effects on the Eye Effects of Antimuscarinics in the CNS Clinical Studies with Other Antimuscarinic Agents and their Therapeutic Uses Use of Antimuscarinic Agents as Adjuncts to Anesthesia Use in Anticholinesterase Poisoning Emesis and Motion Sickness Use in Cerebral Injuries Toxicity of Atropine Toxicity in Animals Toxicity in Man Summary References Index
Adaptronischer Schwingungsabsorber für einen weiten Einsatzbereich (Adaptronic Vibration Absorber for a Wide Field of Applications) (2006)

Abstract In vielen mechanischen Strukturen unserer technisierten Umwelt kommen unerwünschte, fremd- oder selbsterregte Schwingungen vor, die im Hinblick auf geringere Umweltbelastung und höhere Lebensdauer reduziert werden müssen. Dieses Ziel lässt sich häufig mit Hilfe von Schwingungsabsorbern erreichen, die dem schwingenden Hauptsystem entweder kinetische Energie entziehen oder gegenphasige Kompensationskräfte in die Struktur einleiten; dem entsprechend unterscheidet man passive und aktive Absorber. Der vorliegende Beitrag zeigt am Beispiel eines Hilfsmassedämpfers, wie beide Absorberklassen unter Anwendung des adaptronischen Konzepts und durch Einsatz aktiver Werkstoffe in einer einzigen kompakten Baueinheit realisiert werden können. An einer konkreten Anwendung wird abschließend demonstriert, dass sich hiermit auch zeitlich veränderliche Frequenzkomponenten von Strukturschwingungen breitbandig dämpfen lassen.
Recreational physical activity and ovarian cancer in a population‐based case‐control study (2002)

Results from epidemiologic studies of physical activity and ovarian cancer have been inconsistent, with 2 prospective studies reporting a modest positive association. We evaluated this relationship in a population-based case-control study conducted in Massachusetts and Wisconsin. Incident cases diagnosed between 1991 and 1994 were identified through statewide tumor registries. Community controls were selected randomly from lists of licensed drivers and Medicare recipients. Participation in moderate and vigorous recreational physical activity at age 12, age 20 and 5 years prior to diagnosis was assessed by telephone interview. Data were available for 327 cases and 3,129 controls. Results were adjusted for age, parity and other ovarian cancer risk factors. Total and vigorous physical activity were not associated with a substantial decrease in ovarian cancer risk at any age. The relative risk (RR) for women reporting > or = 7 vs. 0 hr/week of recent vigorous activity was 0.85 [95% confidence interval (CI) = 0.39-1.86; p for trend = 0.31]. When metabolic equivalent task (MET) hours of activity were estimated, only women in the highest category had any reduction in risk (RR for > 42 MET-hours/week at the reference age = 0.70; 95% CI = 0.36-1.35; p for trend = 0.41). Overall, our results provide only limited support for an inverse association between recreational physical activity and risk of ovarian cancer.
[Clinical features of late onset dementia with Lewy bodies]. (2000)

We conducted a retrospective study to elucidate clinical features of late onset dementia with Lewy bodies (DLB). Nineteen patients with DLB of neocortical category were neuropathologically diagnosed out of 500 consecutive autopsies at Yokufukai Hospital by using the pathological criteria of the consortium on DLB International Workshop. Medical history and clinical signs and symptoms were reviewed from the medical records. The age at onset was 55-88 years (mean 75.9 years), the age at death was 62-91 years, and duration of illness was 1-14 years. The initial symptoms were memory disturbance (10 cases), delirium (6 cases), gait disturbance (3 cases), visual hallucination (3 cases). We divided nineteen cases of DLB into two group: the age of onset was under 75 years (9 cases) and over 76 years (10 cases). The early onset group showed parkinsonism (67%), and visual hallucination (55%). The sensitivity of the clinical diagnosis of probable DLB based on DLB international workshop consensus criteria was 67%. On the other hand, the late onset group (10cases) presented with delirium (70%), parkinsonism (20%), and visual hallucination (30%). The sensitivity of a clinical diagnosis of probable DLB was 30%. Our results indicated considerable difficulty of the diagnosis of late onset DLB cases by the consensus criteria, requiring more sensitive criteria and diagnostic tests for DLB.
Cadmium in arterial hypertension pathogenesis (2004)

W pracy przedstawiono dane epidemiologiczne, obserwacje kliniczne i wyniki badan doświadczalnych nad rolą kadmu (Cd) w wywolywaniu nadciśnienia tetniczego. Badania kliniczne i doświadczalne wskazują
na mozliwośc rozwoju nadciśnienia tetniczego zarowno przy zawodowym, jak i środowiskowym narazeniu na Cd, natomiast wyniki badan epidemiologicznych nie są jednoznaczne. Spośrod roznych mechanizmow
rozwoju nadciśnienia tetniczego przy narazeniu na Cd decydujące znaczenie mają jego toksyczny wplyw na naczynia i zmiany ich reaktywności, związane prawdopodobnie ze stresem oksydacyjnym.
Strategies for targeting protein therapeutics to selected tissues and cells (2004)

The advent of recombinant biotechnology and the recent sequencing of the human genome now allow for identification of scores of potential protein therapeutics along with the capacity to produce them in quantities and purities required for clinical application. Thus, clinical development of potential protein therapeutics has become as commonplace as development efforts of classical small molecule therapeutics. Whereas small molecule therapeutic lead candidates are identified through screens of large sets of possibilities, therapeutic protein candidates are defined by genetic information as a single composition (or a limited set of isoforms). Small molecule leads are identified through the combined assessment of desired selectivity, biodistribution and pharmacokinetic properties. In essence, these selection parameters emulate the actions of protein therapeutics that function as systemic hormones through their ability to target selective cells and tissues of the body via selective receptor interaction with minimal actions elsewhere. However, many, if not most, potential protein therapeutics do not normally circulate through the body to reach their target cell or tissue; rather, they are frequently synthesised at local sites, act at that site and are degraded without reaching appreciable systemic levels. Dose-limiting adverse events are associated with systemic administration of many of these proteins, restricting their clinical potential. This review examines current strategies to reduce these dose-limiting events by possibly focusing the delivery of potential protein therapeutics to discrete tissues and cells.
Furoquinolines Part VI: Synthesis of Furo(2,3-b)quinolines (1973)

3-Vinyl-2-quinolone, its 6,7-dimethoxy, 7,8-dimethoxy and 6,7-methylenedioxy derivatives are converted into the corresponding 3-acetoxy-2,3-dihydrofuro(2,3-b)quinolines by way of iodoacetoxylation using iodine and excess silver acetate in acetic acid. Dehydroacetoxylation of the acetoxy compounds, accomplished by heating with 88-93% o-phosphoric acid, furnished the corresponding furo(2,3-b)quinolines.
X-Ray Engineering and Its Application. Laser Plasma X-Ray Sources. (1999)

We briefly describe the present status of laser plasma x-ray sources for various applications. One of the main problems in soft x-ray applications is the production of debris by the source, which degrades the quality of the x-ray optics. To overcome this problem we propose the use of a cryogenic target or a high pressure gas-puff target. The cryogenic target provides x-rays as intense as those from a laser-irradiated solid target. Gas-puff targets are created by the pulsed injection of high-density gas through a nozzle. Experiments with plasmas produced using a gas-puff target irradiated with a Nd: YAG laser are described. The obtained results would allow for the development of an efficient and debrisless laser-produced x-ray source that would be useful for applications in various fields.
Swabs and swab-transport media kits in the isolation of upper respiratory bacteria. (1982)

The recovery of upper respiratory tract bacteria on laboratory media from a variety of swabs and swab-transport media kits was examined. Organisms studied included strains of Streptococcus pyogenes, Streptococcus pneumoniae, Staphylococcus aureus, Neisseria meningitidis and Haemophilus influenzae. Although a wide range of results was obtained with regard to variables such as the type of swab or swab-transport media kit used, the time of plating, the temperature of storage of swab-transport media kits, and the nature of the suspension of the organisms, it was generally noted that recovery of organisms was better from swabs held in their plastic containers prior to plating than from swabs held in transport medium.
Self-imaging effect in physical radiometry (1983)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Tomasz Jannson, "Self-imaging effect in physical radiometry," J. Opt. Soc. Am. 73, 402-404 (1983) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Precipitation of Lignin from Softwood Black Liquor: An Investigation of the Equilibrium and Molecular Properties of Lignin (2015)

Extracting lignin from black liquor is an attractive option in modern pulp mills as a unit process for a combined biorefinery. The lignin obtained can be utilized as solid fuel or other high-value added products. The precipitation equilibrium of kraft lignin from softwood black liquor was studied in this work. It was found that with decreasing pH and temperature, or increasing ion strength, the solid yield increases. Moreover, precipitated softwood kraft lignin has a higher molecular weight and contains lower amounts of carbohydrates and phenolic groups than lignin precipitated from mixed hardwood/softwood black liquor. The content of methoxyl groups in softwood kraft lignin was found to decrease with increasing precipitation yield. An empirical model for estimating the precipitation yield of lignin was proposed and evaluated.
Development and Oxidation Resistance of Si-Modifide MCrAlY Coatings on Nb-Base Alloy (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
In VitroandIn VivoExpression of Endothelial von Willebrand Factor and Leukocyte Accumulation after Fractionated Irradiation (2000)

Previous investigations have demonstrated an increased release of von Willebrand factor (VWF; also known as vWF) in endothelial cells after high single-dose irradiation in vitro. We have also found increased levels of Vwf protein in mouse glomeruli after a high single dose of renal irradiation in vivo. In addition, increased numbers of leukocytes were observed in the renal cortex after irradiation in vivo. The aim of the present study was to investigate and quantify these biological processes after clinically relevant fractionated irradiation and to relate them to changes in renal function. A significantly greater increase in release of VWF was observed in cultured human umbilical vein endothelial cells (HUVECs) after fractionated irradiation (20 x 1.0 Gy) than after a single dose of 20 Gy (147% compared to 115% of control, respectively, P < 0.0005). In contrast with the in vitro observations, glomerular Vwf staining was lower after fractionated irradiation in vivo (20 x 2.0 Gy or 10 x 1.6 Gy +/- re-irradiation) than after a single dose of 16 Gy. The number of leukocytes accumulating in the renal cortex was also lower after fractionated in vivo irradiation than after a single radiation dose. The onset of these events preceded renal functional and histopathological changes by approximately 10 weeks. These data indicate that radiation-induced changes in endothelial VWF expression after in vivo irradiation may be distinct from the in vitro observations. Increased VWF expression may reflect pivotal processes in the pathogenesis of late radiation nephropathy and provide a clue to appropriate timing of pharmacological intervention.
Electroporation of RNA stimulates immunity to an encoded reporter gene in mice (2009)

Electroporation is the application of high-voltage short-duration pulses to transiently permeabilize cells, permitting the cellular uptake of macromolecules, including nucleic acid. Although much attention has been focused on DNA vaccines, antigen-encoding RNA molecules may also stimulate immunity. Several methods are being examined in an effort to enhance the efficacy of nucleic acid delivery. One such method is the application of electroporation. The present study was designed to develop electroporation for use as a method of RNA delivery in conjunction with the Semliki Forest virus (SFV) RNA vector system for stimulation of immunity. Expression of SFV-based β-galactosidase and luciferase vectors was observed in the muscle after electroporation. Although some tissue damage was induced following intramuscular injection and electroporation with SFV vector RNA encoding LacZ at optimum pulse conditions, immunity to LacZ was efficiently induced. Following two immunizations, there was a higher IgG2a antibody response with the viral vector delivery and a higher IgG1 response in electroporated rSFV-LacZ RNA immunized mice.
LENGUAJE VIBRATORIO SIMBOLICO NO VERBAL "LIVISIM-NOVER" (1985)

EL DOCTOR CESAR GARCIA GALERA, INVESTIGADOR DE TIEMPO COMPLETO EN EL DEPARTAMENTO DE PSICOFISIOLOGIA DE LA FACULTAD DE PSICOLOGIA, DIO A CONOCER DIVERSOS ASPECTOS DE ESTE NOVEDOSO SISTEMA DE COMUNICACION NO VERBAL LIVISIM-NOVER, EL CUAL SERA DE AMPLIA UTILIDAD EN LA REHABILITACION DE LOS HIPOACUSICOS PROFUNDOS (PERSONAS ADULTAS CON SORDERA PROFUNDA, GENERALMENTE SORDO-MUDOS).