gebhart/patrepeval huggingface dataset:
Development of a mini gamma camera for prostate imaging (2011)

We have tested a concept of a mini gamma camera based on monolithic arrays of MPPCs from Hamamatsu. CsI(Tl), and Cs(Na) arrays and a thin scintillation GSO plate were tested with 122 keV gammas from <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">57</sup> Co sources. The planned application requires placement of this mini-camera in an endorectal probe and thus needs to be very compact and possess high spatial resolution. The high sensitivity and high granularity collimator and gamma shield made out composite material (tungsten powder with epoxy) completes the detector package. We are developing the dual modality (hybrid) imaging prostate probe combining in one compact device a high resolution and high efficiency single gamma imager with an Ultrasound (US) sensor. The US component will typically provide not only the usual structural 3D information, as the standard TransRectal Ultrasound (TRUS) probe, but also the tissue differentiating information through proper US signal analysis, such as elastography. The mini gamma probe will provide the direct metabolic information related to the biological state of the prostate and specifically about the presence of any cancerous structures exhibiting increased metabolic activity, when used with the single gamma labeled dedicated imaging agents for prostate cancer. In addition to cancer diagnosis, the dual-modality Gamma/US prostate probe can be used in biopsy and in surgical guidance.
Autoantibodies Targeting Ficolin‐2 in Systemic Lupus Erythematosus Patients With Active Nephritis (2017)

Our results support the usefulness of anti-ficolin-2 as a complementary serologic biomarker for the diagnosis of active lupus with renal manifestations.
Sleep monitoring and sleep apnea event detection using a 3D camera (2010)

This non-invasive method detects the stages of sleep from the respiratory motion recorded with a 3D time-of-flight (TOF) camera. After the patient falls asleep, his/her muscles relax and the degree of relaxation is different in each sleep stage. The relaxation of abdominal muscles leads to slight variations in the movement of the abdomen in some regions. From 3D video recordings, the signal of respiratory movement is extracted from all visible regions. The characteristic features of different sleep stages are extracted, comparing the correlation (coefficients) between different signals. In a similar way, obstructive sleep apnea events are also detected.
Human B cells differentiate into granzyme B‐secreting cytotoxic B lymphocytes upon incomplete T‐cell help (2011)

Recently, CD4(+) T helper cells were shown to induce differentiation of human B cells into plasma cells by expressing interleukin (IL-)21 and CD40 ligand (CD40L). In the present study we show, that in the absence of CD40L, CD4(+) T cell-derived IL-21 induces differentiation of B cells into granzyme B (GzmB)-secreting cytotoxic cells. Using fluorescence-activated cell sorting (FACS) analysis, ELISpot and confocal microscopy, we demonstrate that CD4(+) T cells, activated via their T-cell receptor without co-stimulation, can produce IL-21, but do not express CD40L and rapidly induce GzmB in co-cultured B cells in an IL-21 receptor-dependent manner. Of note, we confirmed these results with recombinant reagents, highlighting that CD40L suppresses IL-21-induced GzmB induction in B cells in a dose-dependent manner. Surprisingly, although GzmB-secreting B cells did not express perforin, they were able to transfer active GzmB to tumor cell lines, thereby effectively inducing apoptosis. In contrast, no cytotoxic effects were found when effector B cells were activated with IL-2 instead of IL-21 or when target cells were cultured with IL-21 alone. Our findings suggest GzmB(+) cytotoxic B cells may have a role in early cellular immune responses including tumor immunosurveillance, before fully activated, antigen-specific cytotoxic T cells are on the spot. CD40 ligand determines whether IL-21 induces differentiation of B cells into plasma cells or into granzyme B-secreting cytotoxic cells.
Cacheable Decentralized Groups for Grid Resource Access Control (2006)

Sharing data among collaborators in widely distributed systems remains a challenge due to limitations with existing methods for defining groups across administrative domain boundaries with various file systems. Groups in traditional systems are bound to particular domains or file systems using centralized storage locations either beyond ordinary users' ability to manage, inaccessible outside a closed system, or both. We present a method for users to independently create and manage groups on any networked workstation using global user identities and to control access to shared data and storage resources based on group membership, regardless of domain boundaries or underlying file systems. Decentralized groups are decoupled from shared user databases and centralized authentication servers through the use of a virtual user namespace. We describe how owners of shared resources can define security policies through the use of caching, and demonstrate how each caching policy represents tradeoffs between performance, scalability, and consistency
High-throughput computational screening of nanoporous materials in targeted applications (2022)

Given the large number of known and hypothetical nanoporous materials, high-throughput computational screening is an efficient method to identify the current best-performing materials and to guide the design of future materials.
The RNase J-Based RNA Degradosome Is Compartmentalized in the Gastric Pathogen Helicobacter pylori (2020)

Posttranscriptional regulation is a major level of gene expression control in any cell. In bacteria, multiprotein machines called RNA degradosomes are central for RNA processing and degradation, and some were reported to be compartmentalized inside these organelleless cells. The minimal RNA degradosome of the important gastric pathogen <i>Helicobacter pylori</i> is composed of the essential ribonuclease RNase J and RhpA, its sole DEAD box RNA helicase, and plays a major role in the regulation of mRNA decay and adaptation to gastric colonization. Here, the subcellular localization of the <i>H. pylori</i> RNA degradosome was investigated using cellular fractionation and both confocal and superresolution microscopy. We established that RNase J and RhpA are peripheral inner membrane proteins and that this association was mediated neither by ribosomes nor by RNA nor by the RNase Y membrane protein. In live <i>H. pylori</i> cells, we observed that fluorescent RNase J and RhpA protein fusions assemble into nonpolar foci. We identified factors that regulate the formation of these foci without affecting the degradosome membrane association. Flotillin, a bacterial membrane scaffolding protein, and free RNA promote focus formation in <i>H. pylori</i> Finally, RNase J-GFP (RNase J-green fluorescent protein) molecules and foci in cells were quantified by three-dimensional (3D) single-molecule fluorescence localization microscopy. The number and size of the RNase J foci were found to be scaled with growth phase and cell volume as previously reported for eukaryotic ribonucleoprotein granules. In conclusion, we propose that membrane compartmentalization and the regulated clustering of RNase J-based degradosome hubs represent important levels of control of their activity and specificity.<b>IMPORTANCE</b><i>Helicobacter pylori</i> is a bacterial pathogen that chronically colonizes the stomach of half of the human population worldwide. Infection by <i>H. pylori</i> can lead to the development of gastric pathologies such as ulcers and adenocarcinoma, which causes up to 800,000 deaths in the world each year. Persistent colonization by <i>H. pylori</i> relies on regulation of the expression of adaptation-related genes. One major level of such control is posttranscriptional regulation, which, in <i>H. pylori</i>, largely relies on a multiprotein molecular machine, an RNA degradosome, that we previously discovered. In this study, we established that the two protein partners of this machine are associated with the membrane of <i>H. pylori</i> Using cutting-edge microscopy, we showed that these complexes assemble into hubs whose formation is regulated by free RNA and scaled with bacterial size and growth phase. Organelleless cellular compartmentalization of molecular machines into hubs emerges as an important regulatory level in bacteria.
Scalable muscle-actuated human simulation and control (2019)

Many anatomical factors, such as bone geometry and muscle condition, interact to affect human movements. This work aims to build a comprehensive musculoskeletal model and its control system that reproduces realistic human movements driven by muscle contraction dynamics. The variations in the anatomic model generate a spectrum of human movements ranging from typical to highly stylistic movements. To do so, we discuss scalable and reliable simulation of anatomical features, robust control of under-actuated dynamical systems based on deep reinforcement learning, and modeling of pose-dependent joint limits. The key technical contribution is a scalable, two-level imitation learning algorithm that can deal with a comprehensive full-body musculoskeletal model with 346 muscles. We demonstrate the predictive simulation of dynamic motor skills under anatomical conditions including bone deformity, muscle weakness, contracture, and the use of a prosthesis. We also simulate various pathological gaits and predictively visualize how orthopedic surgeries improve post-operative gaits.
Automated labeling of the human brain: A preliminary report on the development and evaluation of a forward-transform method (1997)

A forward-transform method for retrieving brain labels from the 1988 Talairach Atlas using x-y-z coordinates is presented. A hierarchical volume-occupancy labeling scheme was created to simplify the organization of atlas labels using volume and subvolumetric components. Segmentation rules were developed to define boundaries that were not given explicitly in the atlas. The labeling scheme and segmentation rules guided the segmentation and labeling of 160 contiguous regions within the atlas. A unique three-dimensional (3-D) database label server called the Talairach Daemon (http://ric.uthscsa.edu/projects) was developed for serving labels keyed to the Talairach coordinate system. Given an x-y-z Talairach coordinate, a corresponding hierarchical listing of labels is returned by the server. The accuracy and precision of the forward-transform labeling method is now under evaluation.
Robust PSS Design under Multioperating Conditions Using Canonical Particle Swarm Optimization (2007)

Power system stabilizer (PSS) is one the most economical and effective controllers to enhance the power system damping. Under multioperating conditions, the probabilistic PSS (PPSS) design problem can be formulated as a parameter optimization problem with probabilistic eigenanalysis included and the statistical nature of the eigenvalues is described by their expectations and variances. This paper uses the canonical particle swarm optimization to address PPSS design problem so as to overcome the deficiency of traditional derivative-based methods and other heuristic techniques. The effectiveness and robustness of the proposed PSS design approach has been tested based on a three-machine system. A comparison between the proposed approach and a conventional sensitivity-based PSS design method is conducted by nonlinear time domain simulation and the results show the effectiveness of proposed approach. Two performance indices are calculated and the results are in consistence with the transient process simulation.
ChemInform Abstract: Enzymatic Lactonization of γ‐Hydroxy Esters in Organic Solvents. Synthesis of Optically Pure γ‐Methylbutyrolactones and γ‐Phenylbutyrolactones. (1988)

Abstract The γ‐hydroxy esters (I) are cyclized with porcine pancreatic lipase to form the lactones (II).
Single center experience treating adults with FLT3-mutated acute myeloid leukemia (AML). (2012)

6562 Background: Activating mutations of the fms-like tyrosine kinase-3 (FLT3) gene are common in AML. Depending upon the allele mutation fraction, these mutations have been associated with poor outcomes in prospective multi-center trials. Methods: We studied a consecutive series of adults with FLT3-mutated leukemia at our institution since we began testing in 2006 through Sept 2011. Clinical characteristics and patient (pt) outcomes were extracted through a retrospective chart review and analyzed using logistic regression and Cox proportional hazard models. Results: We identified 73 pts with a FLT3 mutation (71 with AML and 2 with myelodysplasia with &lt;20% blasts). 62 (85%) presented to our institution at initial diagnosis; 11 (15%) were diagnosed elsewhere and seen by us only at relapse. 44 (60%) were men and 51 (70%) were white. Median age was 62 yrs (range, 19-90); 48% were &lt;60 yrs old. 63 (86%) had an internal tandem duplication (ITD) mutation, 9 (12%) had the D835 point mutation (TKD), and 1 had both. An NPM1 mutation was also present in 26 (36%). Median white blood cell count at diagnosis was 53 x 10 3 /µL (range, 0.8 - 466). 34 (47%) had monocytic morphology (M4 or M5). 8 (11%) pts had favorable karyotypes; 50 (68%) had normal karyotypes; 13 (18%) had unfavorable karyotypes. 58 (79%) received standard induction therapy (anthracycline + cytarabine for most; ATRA + arsenic trioxide for 3 with APL); 46/58 (79%) achieved a complete remission (CR). Including the 15 pts who received only low intensity therapies, 40/64 (63%) with an ITD and 6/9 (67%) with a TKD mutation achieved CR. 31 (42%) pts received an allogeneic transplant, 21 in first CR (CR1) and 10 after relapse. Median overall survival (OS) for the whole group was 417 days (95% CI: 291-780); it was 684 days for those diagnosed at our institution and 285 days for those seen only after relapse. Median disease-free survival (DFS) in CR1 was 417 days. Median OS for pts transplanted in CR1 was 1262 days from initial diagnosis and 416 days for those transplanted after relapse. DFS did not differ with or without a transplant (median, 526 vs 305 days; p=.64). Conclusions: FLT3-mutated AML is heterogeneous. Our single center experience is similar to that reported from multi-center trials.
Interleukin-1 inhibition, chronic kidney disease-mineral and bone disorder, and physical function (2017)

In conclusion, 12 weeks of IL-1 inhibition did not improve markers of CKD-MBD or physical function. .
Self-aligned formation of the trench bottom shielding region in 4H-SiC trench gate MOSFET (2016)

Abstract To suppress the electric field in the gate oxide in a trench gate MOSFET (UMOSFET) with small cell pitch, we developed a technique to form the p + region using self-aligned ion implantation under the gate trench. To prevent Al + injection into the trench sidewalls, conditions of thin oxide layer deposition and Al + implantation were optimized by process simulation. The resulting SiC trench MOS capacitors exhibited long-term reliability, with no degradation in lifetime by the p + shielding region, and a specific on-resistance of 9.4 mΩ cm 2 with a blocking voltage of 3800 V was achieved in the UMOSFET.
Efficient iterative LP decoding of LDPC codes with alternating direction method of multipliers (2013)

In this paper, we propose an efficient message-passing algorithm to solve the LP decoding problem. This algorithm is based on the alternating direction method of multipliers (ADMM), a classic technique in convex optimization theory that is designed for parallel implementation. The computational complexity of ADMM-based LP decoding is largely determined by the method used to project a vector of real values to the parity polytope of a given parity check. The key contribution of this paper is a novel, efficient projection algorithm that can substantially improve the decoding speed of the ADMM-based LP decoder.
Wideband CMOS RF front-end receiver with integrated filtering (2015)

A wideband CMOS receiver front-end for radio applications operating between 300 MHz and 900 MHz is presented. In order to obtain channel selection with image-rejection and out-of-band interferers attenuation, both low-noise amplifier (LNA) and mixer incorporate a N-Path signal processing technique. The effectiveness of this N-Path filtering is investigated by comparing distinct combinations of clock phases and respective duty cycle. Using a standard 130 nm CMOS technology and a supply voltage of 1.2 V, it was possible to obtain a voltage gain greater than 28 dB, a noise figure (NF) lower than 6.05 dB and IIP3 > -1.54 dBm.
On phenomenological mechanochemical muscle models – II (1981)

Using the kinetic models developed in Part I, a set of general continuum thermodynamic constitutive equations of the internal state variable type are proposed for striated muscle tissue and analyzed. Restrictions put on the arguments of the stress te
Isolation of Mutants of Namalwa Cells Differing in their Ability to Produce Interferon (1982)

SUMMARY We have generated several variants of the human lymphoid cell line Namalwa which were characterized as high producers, non-producers and spontaneous producers of interferon (IFN). All of them were stable for more than 1 year, suggesting chromosomal inheritance of their mutations. We show the kinetics and quantity of IFN production following treatment with several inducers, including polyriboinosinic-polyribocytidylic acid [poly(rI).poly(rC)].
The role of advection and of work done by forces in the gustiness of the Bora flow (2014)

Local wind changes within the flow of the Adriatic Bora are investigated in the case of 8 December 2001 that was simulated with the WRF/ARW model in a 333 m horizontal resolution and with all relevant model variables archived during a 3 h time interval with 1 s temporal resolution. Along a selected cross section, two locations of strong gusts in the lee of a Dinaric mountain ridge are found - the upper one on the slope and the other over the sea close to the coastline; in between the wind is considerably weaker. About 16 to 18 gusts developed in the 3 h interval at both locations with an average period of approximately 8.5 min. The advective transport of kinetic energy (KE), the work of the unbalanced part of the pressure gradient force and the diffusion and dissipation of&nbsp;KE&nbsp;cause the local change ΔKE, and their quasi-periodic fluctuations lead to gusts and lulls. The results of the numerical simulation enable an estimation of the contributions of advection, the work of forces and of turbulence and dissipation effects. Advective contributions to local changes are more or less in the phase with ΔKE&nbsp;and ahead of the phase of&nbsp;KE, while the contributions of work are generally smaller and in the opposite phase: so in general the advection and the work effects oppose each other. The advection and the work effects are not spatially homogeneous, i.e. they cease and even change their sign between the two locations of the strongest gusts and so there is no continuous displacement of&nbsp;KE from the upper to the lower location by either of the two effects: their contributions interchange with each other down the slope.
Gas Chromatography of Trimethylsilyl Derivatives of Compounds Related to Chloramphenicol. (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGas Chromatography of Trimethylsilyl Derivatives of Compounds Related to Chloramphenicol.P. D. ShawCite this: Anal. Chem. 1963, 35, 11, 1580–1582Publication Date (Print):October 1, 1963Publication History Published online1 May 2002Published inissue 1 October 1963https://pubs.acs.org/doi/10.1021/ac60204a010https://doi.org/10.1021/ac60204a010research-articleACS PublicationsRequest reuse permissionsArticle Views37Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Hydrogen Resistivity Sensors From Nanoparticle Assembles: Palladium Versus Platinum (2013)

Abstract not Available.
Large-Scale Synthesis of Thiolated Au25 Clusters via Ligand Exchange Reactions of Phosphine-Stabilized Au11 Clusters (2005)

Phosphine-stabilized Au11 clusters in chloroform were reacted with glutathione (GSH) in water under a nitrogen atmosphere. The resulting Au:SG clusters exhibit an optical absorption spectrum similar to that of Au25(SG)18, which was isolated as one of the major products from chemically prepared Au:SG clusters (Negishi, Y. et al. J. Am. Chem. Soc. 2005, 127, 5261). Rigorous characterization by optical spectroscopy, electrospray ionization mass spectrometry, and polyacrylamide gel electrophoresis confirms that the Au25(SG)18 clusters were selectively obtained on the sub-100 mg scale by ligand exchange reaction under aerobic conditions. The ligand exchange strategy offers a practical and convenient method of synthesizing thiolated Au25 clusters on a large scale.
Predicting Production Outcome from Multi-stage, Horizontal Barnett Completions (2009)

Abstract Developing a predictive reservoir model involves determination or estimation of key reservoir components, which can vary through the rock volume. Sophisticated, 3-D grid models usually require significant input data and are built for conventional reservoirs producing in Darcy flow. Production from the Barnett shale is not conventional. Shale-rock gas flow involves a complex mixture of free and adsorbed storage and production mechanisms. Free gas can be stored in the microporosity, natural fractures, or thin lamination existing or created during hydraulic fracturing. Adsorbed gas is contained in the organic material randomly distributed in the bulk rock. Horizontal, multistage-fractured wellbores add another level of complexity. Massive hydraulic fracturing of horizontal shale has shown complex fracture networks are created along the wellbore. Mapped data suggests multiple fracture planes are created during injection. These fracture planes can be irregular in length and are not always symmetrical. Conventional reservoir models can not handle this level of complexity. A new, 3-D, four-phase, nonisothermal, multiwell black oil and "Pseudo-compositional" simulator that allows placement of multiple transverse fractures along the horizontal has been developed. Its ability to model horizontal, multiwing, transverse fractures and account for all three reservoir phases, including injected fluid, makes this model more predictive of production. This paper uses mapped fracture dimensions of horizontal wells in the north Texas Barnett (NTB) to build a reservoir model. Comparisons of model production to real production are made to demonstrate the model's predictive ability.