gebhart/patrepeval huggingface dataset:
Overview of 1-Methylcyclopropene Trials and Uses for Edible Horticultural Crops (2008)

The inhibitor of ethylene perception, 1-methylcyclopropene (1-MCP), is the basis of a new technology that is increasingly being used to improve storage potential and maintain quality of fruit and vegetables. 1-MCP is registered for use on a number of crops, including apple, apricot, avocado, banana, broccoli, kiwifruit, pear, mango, melon, peach, nectarine, persimmon, plum, and tomato. The registered crop is often specific to country. The effects of 1-MCP on quality of these crops, as well as its effects on physiological disorders and pathological diseases, are reviewed. Most available literature on 1-MCP has focused on laboratory-based trials and little information exists about its effects on product quality at the commercial level. The apple is the most significant exception, being the first crop for which 1-MCP was used commercially and extensively around the world. The apple is a crop for which limited ripening after harvest is desirable. For many other fruit, successful commercialization of 1-MCP will require an appropriate balance between 1-MCP concentrations and exposure periods that will delay but not inhibit ripening. The effects of preharvest factors, cultivar, maturity, and postharvest practices are complex and will impact commercial success of 1-MCP-based technology. For leafy or nonfruit vegetables, the advantages of 1-MCP may only be apparent under abusive conditions such as high temperatures and exogenous ethylene exposure. Finally, commercial utilization of 1-MCP-based technology will be a function of the cost of its application relative to its benefits for each product.
Supported/Tagged Scavengers for Facilitating High‐Throughput Chemistry (2008)

This chapter contains sections titled: Introduction Supported/Tagged Reactive Functionalities for the Sequestration of Nucleophiles (Nucleophile/Electrophilic Scavengers) Supported/Tagged Reactive Functionalities for the Sequestration of Electrophiles (Electrophile/Nucleophilic Scavengers) Conclusion References
A computational observer model of spatial contrast sensitivity: Effects of wavefront-based optics, cone mosaic structure, and inference engine (2018)

We present a computational observer model of the human spatial contrast sensitivity (CSF) function based on the Image Systems EngineeringTools for Biology (ISETBio) simulation framework. We demonstrate that ISETBio-derived CSFs agree well with CSFs derived using traditional ideal observer approaches, when the mosaic, optics, and inference engine are matched. Further simulations extend earlier work by considering more realistic cone mosaics, more recent measurements of human physiological optics, and the effect of varying the inference engine used to link visual representations to psy-chohysical performance. Relative to earlier calculations, our simulations show that the spatial structure of realistic cone mosaics reduces upper bounds on performance at low spatial frequencies, whereas realistic optics derived from modern wavefront measurements lead to increased upper bounds high spatial frequencies. Finally, we demonstrate that the type of inference engine used has a substantial effect on the absolute level of predicted performance. Indeed, the performance gap between an ideal observer with exact knowledge of the relevant signals and human observers is greatly reduced when the inference engine has to learn aspects of the visual task. ISETBio-derived estimates of stimulus representations at different stages along the visual pathway provide a powerful tool for computing the limits of human performance.
Capsaicin‐desensitization to the human nasal mucosa selectively reduces pain evoked by citric acid. (1993)

1. Kallidin (5-500 nmol), hypertonic saline (0.9-20% NaCl) or low pH medium (citric acid: pH 2.5-1) applied (50 microliters) to the human nasal mucosa produced a pain response (evaluated by a visual analogue scale) that was related to the concentration of the peptide, NaCl or hydrogen ions, respectively. 2. Application (50 microliters) of capsaicin (50 nmol) to the human nasal mucosa produced overt pain. After repeated administrations (once a day for 5-7 days) to one nostril this effect underwent almost complete desensitization, while in the contralateral nostril, treated with the vehicle, the response to capsaicin was unaffected. 3. The pain response produced in the human nasal mucosa by topical application (50 microliters) or kallidin (50-500 nmol), NaCl (10-20%) or citric acid (pH 1.5-1) solutions was then studied before and after local capsaicin desensitization. 4. The pain response to pH 1.5 or 1 citric acid was markedly reduced (by 60% and 75%, respectively) in the capsaicin-treated nostril. However, the pain response to 10% or 20% NaCl or the mild pain response to 50 or 500 nmol kallidin were unaffected by capsaicin pre-treatment. 5. The present results suggest that prolonged topical capsaicin treatment to the human nasal mucosa may lead to selective desensitization to certain algesic stimuli such as capsaicin itself and hydrogen ions.
Modelling of sulfur deactivation of naphtha-reforming catalysts Structure sensitivity in cyclopentane hydrogenolysis (1997)

The effect of particle size and the addition of Ir on the relative sulfur sensitivity of Pt-based catalysts has been studied. Cyclopentane hydrogenolysis, a structure-sensitive reaction, was employed as a test reaction and thiophene as the poisoning molecule. Fresh and sintered monometallic Pt/Al 2 O 3 and bimetallic Pt–Ir/Al 2 O 3 catalysts were used. Sulfur poisoning in the presence of simultaneous coke deactivation was characterised by two deactivation kinetic models. Model I assumes a single deactivation order for both deactivation causes, whereas in model II different deactivation orders were assumed (d c =1, d s =0.5). Thioresistance, calculated from the above models as the number of sulfur atoms initially needed to deactivate one atom of exposed Pt, was in the order: Pt-2Pt-1>Pt-1APt–IrPt-2A. According to the deactivation models, thioresistance mainly depends on k s , the specific rate constant of hydrogenolysis of adsorbed thiophene. The higher the hydrogenolytic constant, the lower the thioresistance. Moreover, both cyclopentane hydrogenolysis and sulfur poisoning depend on the mean particle size. When the particle size was increased, a higher hydrogenolytic activity and a lower thioresistance were observed. Thus sulfur deactivation is also a structure-sensitive reaction.
Stable isotopes for determining biokinetic parameters of tellurium in rabbits (1991)

We have compared the use of stable and radioactive isotopes for determining the concentration of tellurium in body fluids of animals and man, specifically in the blood plasma of rabbits. Particular effort has been devoted to developing a sample-processing technique that allows the total amount of tellurium and isotope ratios to be measured by graphite furnace atomic absorption spectrometry (GFAAS) and secondary ion mass spectrometry (SIMS), respectively. The procedure employed in the SIMS analysis is discussed in detail. Investigations on the plasma clearance and the fractional intestinal absorption were carried out on four rabbits. Tracer solutions containing stable tellurium enriched in 124Te or 126Te and radioactive tellurium (121mTe or 123mTe) were administered by gavage and/or intravenously. Blood samples were drawn during the first 2 days after application. The activity of the separated plasma was measured by standard gamma ray spectrometry. After wet ashing and solvent extraction with MIBK the samples were analyzed for stable tellurium. A detection limit of 1 ng/mL of plasma could be achieved with GFAAS. For SIMS analysis the processed samples were deposited on high-purity graphite backings. Reliable isotope ratios could be determined with sample fractions containing 1 ng of tellurium or even less. The results obtained by applying stable isotopes were found to be in good agreement with the data achieved by using radioactive tracers. Studies on the intestinal absorption and the metabolic behavior of tellurium in human volunteers may thus be performed with stable isotopes.
Hydrosilation of 1‐alkyne at nearly flat, terraced, homogeneously hydrogen‐terminated silicon (100) surfaces (2005)

Abstract An experimental study of the derivatization of Si(100) surfaces with 1‐octyne has been carried out via x‐ray photoelectron spectroscopy at different take‐off angles, and infrared absorption spectroscopy in attenuated total reflection mode and atomic force microscopy have been used to characterize the pristine surface. Our study has shown that it is possible to prepare nearly flat, terraced, homogeneously hydrogen‐terminated Si(100) surfaces via exposure to H 2 at high temperature (1100 °C) and that these surfaces may be functionalized with hydrocarbon moieties by simple immersion in the unsaturated hydrocarbon at ∼200 °C. Copyright © 2004 John Wiley &amp; Sons, Ltd.
Progress in the Chemistry of Organic Natural Products, 86 Edited by W. Herz (The Florida State University, Tallahassee), H. Falk (Johannes-Kepler-Universität), and G. W. Kirby (University of Glasgow). Featuring “Monopyrrolic Natural Compounds Including Tetramic Acid Derivatives” by A. Gossauer (University of Fribourg). Springer-Verlag:  Wien. 2003. viii + 222 pp. $149.00. ISBN 3-211-83889-9. (2003)

ADVERTISEMENT RETURN TO ISSUEPREVBook ReviewNEXTProgress in the Chemistry of Organic Natural Products, 86 Edited by W. Herz (The Florida State University, Tallahassee), H. Falk (Johannes-Kepler-Universität), and G. W. Kirby (University of Glasgow). Featuring "Monopyrrolic Natural Compounds Including Tetramic Acid Derivatives" by A. Gossauer (University of Fribourg). Springer-Verlag: Wien. 2003. viii + 222 pp. $149.00. ISBN 3-211-83889-9.Philip DeShongView Author Information University of MarylandCite this: J. Am. Chem. Soc. 2003, 125, 47, 14649–14650Publication Date (Web):October 17, 2003Publication History Published online17 October 2003Published inissue 1 November 2003https://pubs.acs.org/doi/10.1021/ja0335869https://doi.org/10.1021/ja0335869book-reviewACS PublicationsCopyright © 2003 American Chemical SocietyRequest reuse permissionsArticle Views200Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Fungi,Pharmaceuticals,Pyrroles,Reaction products,Structure determination Get e-Alerts
PSIV-B-23 Late-Breaking: Detection of dietary external markers using portable X-ray fluorescence spectrometry for estimation of digestibility in beef cattle (2019)

Abstract The use of portable X-ray fluorescence (PXRF) spectrometry to detect dietary external markers on processed or unprocessed bovine fecal specimens to estimate apparent total tract digestibility (ATTD) was evaluated. Seven beef crossbred, ruminally-cannulated steers (BW = 520 ± 30 kg) were used in a completely randomized design. Steers were individually fed a steam-flaked corn-based finishing diet ad libitum for 21-d. Degradable gel capsules containing 7.5 g of titanium dioxide and chromic oxide were placed inside the rumen through the ruminal-cannulae twice daily, throughout the experiment. Fecal samples were collected twice daily from d 14–21, stored frozen (-20oC), and thawed on d-21 to make a composite sample per steer/day. Wet chemistry analyses of fecal samples included atomic absorption for Cr and spectrophotometry for TiO2 and were compared with PXRF to determine the concentration of these markers on three types of fecal specimens: fresh (average 22.5 % DM), dried (60oC, 72 h), or dried/ground (1 mm). Data were analyzed using the GLIMMIX procedures of SAS with collection day as a repeated measure. Delta between ATTD estimated by wet chemistry and PXRF was not different from zero when using fresh fecal specimens analyzed for Cr (P = 0.40) or Ti (P = 0.14), while for dried or dried/ground specimens it differed (P ≤ 0.04), in which ATTD was underestimated by 3.6 and 1.1 percent units for Cr and Ti, respectively, when using PXRF. Concentration of Ti in fecal specimens was similar (P = 0.39) between analytical methodologies regardless of sample preparation. However, concentration of Cr was underestimated (P &amp;lt; 0.01) by 13% when PXRF was used in dried or dried/ground fecal samples compared to wet chemistry. Detection of Cr and Ti in fresh fecal samples with PXRF spectrometry seems to be a viable alternative to wet chemistry for estimating ATTD for finishing steers.
End-user-oriented telco mashups (2012)

With the success of Web 2.0 we are witnessing a growing number of services and APIs exposed by Telecom, IT and content providers. Targeting the Web community and, in particular, Web application developers, service providers expose capabilities of their infrastructures and applications in order to open new markets and to reach new customer groups. However, due to the complexity of the underlying technologies, the last step, i.e., the consumption and integration of the offered services, is a non-trivial and time-consuming task that is still a prerogative of expert developers. Although many approaches to lower the entry barriers for end users exist, little success has been achieved so far. In this paper, we introduce the OMELETTE project and show how it addresses end-user-oriented telco mashup development. We present the goals of the project, describe its contributions, summarize current results, and describe current and future work.
The trimeric solution structure and fucose-binding mechanism of the core fucosylation-specific lectin PhoSL (2018)

The core α1-6 fucosylation-specific lectin from a mushroom Pholiota squarrosa (PhoSL) is a potential tool for precise diagnosis of cancers. This lectin consists of only 40 amino acids and can be chemically synthesized. We showed here that a synthesized PhoSL peptide formed a trimer by gel filtration and chemical cross-linking assays, and determined a structure of the PhoSL trimer by NMR. The structure possesses a β-prism motif with a three-fold rotational symmetry, where three antiparallel β-sheets are tightly connected by swapping of β-strands. A triad of Trp residues comprises the structural core, forming NH-π electrostatic interactions among the indole rings. NMR analysis with an excess amount of fucose revealed the structural basis for the molecular recognition. Namely, fucose deeply enters a pocket formed at a junction of β-sheet edges, with the methyl group placed at the bottom. It forms a number of hydrophobic and hydrogen-bonding interactions with PhoSL residues. In spite of partial similarities to the structures of other functionally related lectins, the arrangement of the antiparallel β-sheets in the PhoSL trimer is novel as a structural scaffold, and thus defines a novel type of lectin structure.
Cryoelectron Microscopy and EPR Analysis of Engineered Symmetric and Polydisperse Hsp16.5 Assemblies Reveals Determinants of Polydispersity and Substrate Binding (2006)

We have identified sequence and structural determinants of oligomer size, symmetry, and polydispersity in the small heat shock protein super family. Using an insertion mutagenesis strategy that mimics evolutionary sequence divergence, we induced the ordered oligomer of Methanococcus jannaschii Hsp16.5 to transition to either expanded symmetric or polydisperse assemblies. A hybrid approach combining spin labeling EPR and cryoelectron microscopy imaging at 10A resolution reveals that the underlying plasticity is mediated by a packing interface with minimal contacts and a flexible C-terminal tether between dimers. Twenty-four dimeric building blocks related by octahedral symmetry assemble into the expanded symmetric oligomer. In contrast, the polydisperse variant has an ordered dimeric building block that heterogeneously packs to yield oligomers of various sizes. Increased exposure of the N-terminal region in the Hsp16.5 variants correlates with enhanced binding to destabilized mutants of T4 lysozyme, whereas deletion of this region reduces binding. Transition to larger intermediates with enhanced substrate binding capacity has been observed in other small heat shock proteins including lens alpha-crystallin mutants linked to congenital cataract. Together, these results provide a mechanistic perspective on substrate recognition and binding by the small heat shock protein superfamily.
Advances in the identification of molecular markers for bone neoplasia (2010)

Molecular analysis has identified key diagnostic biomarkers in only a small proportion of bone tumors. Many of these findings owe their existence to earlier karyotype-based cytogenetic studies. In cases where characteristic cytogenetic findings are absent, there remains a tremendous need to interrogate rigorously these lesions using emerging techniques such as whole genome sequencing. It is assumed that with a more precise understanding of the tumor genetic code, more accurate diagnostic, prognostic and therapeutic markers will emerge.
Effectiveness of warm-up interventions on work-related musculoskeletal disorders, physical and psychosocial functions among workers: a systematic review (2023)

CRD42019137211.
How Can We Help Healthcare Workers during a Catastrophic Event Such as the COVID-19 Pandemic? (2022)

Healthcare workers (HCWs) have significantly suffered during the COVID-19 pandemic, reporting a high prevalence of anxiety, depression and post-traumatic stress disorder (PTSD). We investigated with this survey whether HCWs benefitted from supportive measures put in place by hospitals and how these measures were perceived. This cross-sectional survey, which was conducted during the first wave of COVID-19 at the Geneva University Hospitals, Switzerland, between May and July 2021, collected information on the use and perception of practical and mental health support measures provided by the hospital. In total, 3461 HCWs participated in the study. Regarding the practical support measures, 2896 (84%) participants found them useful, and 2650 (76%) used them. Regarding the mental health support measures, 3149 (90%) participants found useful to have the possibility of attending hypnosis sessions, 3163 (91%) to have a psychologist within hospital units, 3202 (93%) to have a medical nursing psychiatric permanence available seven days a week, and 3171 (92%) to have a hotline available seven days a week. In total, 436 (13%) HCWs used at least one of the available mental health support measures. During the COVID-19 pandemic, the support measures were valued by HCWs. Given the high prevalence of psychiatric issues among HCWs, these measures seem necessary and are likely to have alleviated the suffering of HCWs.
Electrical Studies of Neutron-Irradiated p-Type Silicon: Defect Structure and Annealing (1968)

Defects produced in float-zone and crucible-grown p-type silicon by neutron irradiation at 76°K were investigated, using electrical conductivity and Hall-effect measurements. The behavior of the neutron-produced defects is independent of the crystal growth, and exhibits an illumination dependence similar to that previously observed in n-type silicon and attributed to the presence of defect clusters. The neutron-produced changes in the electrical properties of p-type silicon at 76°K are therefore ascribed to defect clusters. The annealing loss of the light-sensitive defects occurs in diffuse stages between 150° and 550°K. The largest stage is observed between 150° and 240°K. A major fraction of the hole-mobility annealing parallels the annealing for the light-sensitive defects, and suggests that the mobility change caused by defect clusters is significantly larger than that caused by isolated defects formed from cluster dissociation. The most apparent crystal-growth-dependent annealing is observed between 540° and 620°K, where a reverse annealing occurs in the hole-removal rate for crucible-grown, but not for float-zone, silicon. The fractions of the neutron-produced decreases in hole concentration and mobility which remain after 700°K annealing are, respectively, ∼0.1 and 0.01 for float-zone, and ∼0.25 and 0.1 for crucible-grown silicon.
Structure and Expression of a Smooth Muscle Cell-specific Gene, SM22α (1995)

SM22 alpha is expressed exclusively in smooth muscle-containing tissues of adult animals and is one of the earliest markers of differentiated smooth muscle cells (SMCs). To examine the molecular mechanisms that regulate SMC-specific gene expression, we have isolated and structurally characterized the murine SM22 alpha gene. SM22 alpha is a 6.2-kilobase single copy gene composed of five exons. SM22 alpha mRNA is expressed at high levels in the aorta, uterus, lung, and intestine, and in primary cultures of rat aortic SMCs, and the SMC line, A7r5. In contrast to genes encoding SMC contractile proteins, SM22 alpha gene expression is not decreased in proliferating SMCs. Transient transfection experiments demonstrated that 441 base pairs of SM22 alpha 5'-flanking sequence was necessary and sufficient to program high level transcription of a luciferase reporter gene in both primary rat aortic SMCs and A7r5 cells. DNA sequence analyses revealed that the 441-base pair promoter contains two CArG/SRF boxes, a CACC box, and one potential MEF-2 binding site, cis-acting elements which are each important regulators of striated muscle transcription. Taken together, these studies have identified the murine SM22 alpha promoter as an excellent model system for studies of developmentally regulated, lineage-specific gene expression in SMCs.
The use of calcite mineral thermoluminescence for the determination of previously received gamma radiation dose in foodstuffs/E1 uso de la termoluminiscencia de la calcita para la determinación de la dosis de radiación gamma de alimentos previamente irradiados (1996)

This paper describes the potential use of calcite mineral dust as a high-dose radiation dosemeter. The results obtained show that saturation dose in natural calcite is of the order of 7 kGy. Measurements of absorbed dose, for samples previously irradiated with known gamma doses, showed a good level of agreement between actual doses and calculated doses, although the level of scatter is high.