gebhart/patrepeval huggingface dataset:
Radioprotection of mouse hematopoietic stem cells by leukotriene A4 and lipoxin B4. (1988)

The potent cyto/radioprotective biological activity induced by leukotrienes prompted a search for other lipoxygenase products exhibiting similar properties. Pretreatment of mice with 1 to 20 μg of leukotriene A4 before sublethal irradiation induced an increase in the number of endogenous hematopoietic stem cells. Radioprotection was also provided by pretreatment with lipoxin B4, but not with lipoxin A4 or with potential lipoxin precursors: 5-HETE, 15-HPETE, 15-HETE, and arachidonic acid. The degree of protection induced by leukotriene A4 or lipoxin B4 is less than that previously reported for an equivalent dose of leukotriene C4. Administration of the lipoxins did not result in any visibly detectable side effects such as diarrhea or ataxia.
High-frequency crowd insights for public safety and congestion control (2019)

We present results from several projects aimed at enabling the real-time understanding of crowds and their behaviour in the built environment. We make use of CCTV video cameras that are ubiquitous throughout the developed and developing world and as such are able to play the role of a reliable sensing mechanism. We outline the novel methods developed for our crowd insights engine, and illustrate examples of its use in different contexts in the urban landscape. Applications of the technology range from maintaining security in public spaces to quantifying the adequacy of public transport level of service.
Measurement of Brillouin gain spectrum distribution along an optical fiber with a high spatial resolution using a novel correlation-based technique: demonstration of 45cm spatial resolution (1999)

Brillouin gain spectrum distribution along an optical fiber is measured by a correlation-based technique with frequency-modulated pump and probe lightwaves. The spatial-resolution of 45cm is demonstrated, which cannot be realized by the conventional pulse-based technique.
Modeling of high-current damage in SiGe HBTs under pulsed stress (2016)

High-current pulsed stress measurements are performed on SiGe HBTs to characterize the damage behavior and create a comprehensive physics-based TCAD damage model for Auger-induced hot-carrier damage. The Auger hot-carrier generation is decoupled from classical mixed-mode damage and annealing on the output plane by using pulsed stress conditions to modulate the self-heating within the device under stress. The physics of high-current degradation is analyzed, and a temperature dependent degradation model is presented. This model is the first of its kind in both the CMOS and bipolar communities and solves a significant portion of the puzzle for predictive modeling of SiGe HBT safe-operating-area (SOA) and reliability.
Association of Kallikrein gene polymorphisms with sporadic intracranial aneurysms in the Chinese population (2014)

The variant rs1722561 of Kallikreins might reduce the risk of sporadic IAs among individuals of Chinese Han ethnicity. This study confirms the association between Kallikreins and IAs.
Effect of streptomycin administration on association of enteric pathogens with cecal tissue of mice (1989)

The effect of streptomycin on the ability of Shigella sonnei 3SR and enterotoxigenic Escherichia coli 2SR to associate with cecal tissue of mice in vivo and in vitro was examined. After orogastric challenge, both pathogens associated in significantly greater numbers (P less than or equal to 0.05) with the cecal tissue of streptomycin-treated mice than with the tissue of untreated mice. The population levels of the pathogens were also significantly greater (P less than or equal to 0.05) in the cecal contents of streptomycin-treated mice than in untreated mice. When excised cecal tissues from the two groups of mice were exposed to the pathogens in vitro, the extent of the association of the pathogens was markedly greater with tissues from streptomycin-treated mice than with tissues from untreated mice. There was also a positive correlation between the numbers of the pathogens in the suspending fluid and the extent of the tissue associations. The population size of fusiform organisms, which are the major components of the mucus layer of the ceca of mice, was reduced 100-fold by streptomycin administration. This was determined by microscopic count. Sections of cecal tissue obtained from the mice and stained with hematoxylin and eosin demonstrated that streptomycin administration greatly decreased the number of fusiform bacteria present in the mucosal microbial layer. We speculate that the partial elimination of fusiform organisms from this layer by streptomycin administration provides available association sites for pathogens so that they can successfully colonize the mouse cecum.
SAXTON PLUTONIUM PROGRAM. MATERIALS DESIGN AND FABRICATION OF THE SAXTON PARTIAL PLUTONIUM CORE (1965)

The materials design and fuel fabrication portions. of the Saxton Plutonium Project are described.The purpose of the Saxton Plutonium Project is to develop information concerning the utilization of plutonium-enriched fuel in pressurized water reactor systems, through design, fabrication and operation of a partial core of Pu02-U02 fuel in the Saxton Reactor.Materials design entailed selection of the cladding and fuel rod fabrication techniCJ.uesemployed for the project, development of fuel specifications, and providing materials information to other design groups for establishing design parameters and safety criteria.The fabrication techniCJ.uesselected were vibrational compaction and pelletization of mechanically-mixed powder.Reasons for these selections are given. Also, the procedures used during manufacturing of the fuel rods and results of inspection and CJ.Uality control are summarized.'!'he fuel rods are expected to operate at maximum linear rod powers of 16 Kw/ft and peak exposures greater than 25,000 MWD/Tonne (Pu+U).Fuel central temperatures as high as 2100C are expected.'t the Euratom Comnns-1 Commission, the European Atomic Energy om.mun1.y,.aion, nor any persuu a\..t.i.
Preferential VH gene usage in rabbit Ig-secreting heterohybridomas. (1994)

B cells from leukemic rabbits preferentially use a single VH gene, VH1, in their VDJ gene rearrangements. To determine whether Ig-secreting B cells from normal rabbits also preferentially use VH1, we generated rabbit X mouse heterohybridomas that stably secreted rabbit Ig that expressed VHa allotypic specificities and analyzed the VH genes used in their VDJ gene rearrangements. We cloned the VDJ genes from nine heterohybridomas, and by comparing the restriction map of the DNA immediately 5' of the translational start site of these VDJ genes to that of the same region 5' of VH1, we showed that eight of the nine heterohybridoma clones use VH1. Comparison of the nucleotide sequences of the eight VH1-using VDJ genes with the nucleotide sequence of germ-line VH1 showed that each of them had somatically diversified. The diversified regions included clustered nucleotide changes and codon insertions and deletions, such as would be expected if the diversification process involved somatic gene conversion. We searched our database of germ-line VH genes for genes that could serve as donors for the gene conversion events, and we identified potential VH donor genes for five regions of diversification. One of these regions of diversification spanned at least 132 bp and included a codon insertion as well as 15 nucleotide changes. The data confirm that Ab diversity may be generated by a somatic gene conversion-like mechanism. The results directly demonstrate that Ig-secreting B cells from normal rabbits preferentially use VH1 in their VDJ gene rearrangements.
Hemagglutination, Adherence, and Surface Properties of Vaginal Lactobacillus Species (1995)

To address the poorly understood mechanisms through which lactobacilli adhere to vaginal epithelial cells (VECs), 65 wild type lactobacilli isolated from the vaginal flora of young women and 3 American Type Culture Collection Lactobacillus strains were studied. Group I isolates (n = 56) hemagglutinated sheep, rabbit, and human red blood cells (RBCs) and adhered poorly to VECs. In contrast, all 4 group II strains hemagglutinated sheep and human but not rabbit RBCs, adhered in large numbers to VECs, and were identical in five phenotypic tests and DNA-DNA hybridization. Eight other strains (group III) hemagglutinated all RBC types studied, adhered avidly to VECs, and had identical protein and hybridization patterns but showed heterogeneous enzyme activities. Although most wild type lactobacilli from the vaginal flora of young women adhered poorly to VECs, selected isolates (groups II and III) adhered in large numbers, demonstrated specific and reproducible hemagglutination patterns, and may have specific mechanisms of attachment to VECs.
Organic Base-Catalyzed C–S Bond Construction from CO2: A New Route for the Synthesis of Benzothiazolones (2018)

The synthesis of organosulfur compounds via the construction of C−S bonds using CO2 as a C1 resource is very interesting. Herein, a novel method of synthesizing benzothiazolones via the cyclocarbonylation of 2-aminothiophenols with CO2 was developed. A series of organic bases was investigated for the catalysis of cyclocarbonylation, and 1,5-diazabicyclo[4.3.0]non-5-ene (DBN) displayed the best catalytic activity. Then, various reaction parameters such as CO2 pressure, temperature, amount of catalyst, and reaction time for the catalytic performance were studied. Finally, a series of benzothiazolones was synthesized under the optimal reaction conditions, and a possible catalytic mechanism was also proposed.
DS3: A System-Level Domain-Specific System-on-Chip Simulation Framework (2020)

Heterogeneous systems-on-chip (SoCs) are highly favorable computing platforms due to their superior performance and energy efficiency potential compared to homogeneous architectures. They can be further tailored to a specific domain of applications by incorporating processing elements (PEs) that accelerate frequently used kernels in these applications. However, this potential is contingent upon optimizing the SoC for the target domain and utilizing its resources effectively at runtime. To this end, system-level design - including scheduling, power-thermal management algorithms and design space exploration studies - plays a crucial role. This article presents a system-level domain-specific SoC simulation (DS3) framework to address this need. DS3 enables both design space exploration and dynamic resource management for power-performance optimization of domain applications. We showcase DS3 using six real-world applications from wireless communications and radar processing domain. DS3, as well as the reference applications, is shared as open-source software to stimulate research in this area.
The Wsu Model For Engineering Mathematics Education: A Multiyear Assessment And Expansion To Collaborating Institutions (2020)

The inability of incoming students to advance past the traditional first-year calculus sequence is a primary cause of attrition in engineering programs across the country. As a result, this paper will describe an NSF funded initiative at Wright State University to redefine the way engineering mathematics is taught, with the goal of increasing student retention, motivation and success in engineering. The WSU approach begins with the development of a novel first-year engineering mathematics course, EGR 101 "Introductory Mathematics for Engineering Applications." Taught by engineering faculty, the course includes lecture, laboratory and recitation components. Using an application-oriented, hands-on approach, the course addresses only the salient math topics actually used in core engineering courses. These include the traditional physics, engineering mechanics, electric circuits and computer programming sequences. The EGR 101 course replaces traditional math prerequisite requirements for the above core courses, so that students can advance in the curriculum without having completed a traditional first-year calculus sequence. The WSU model concludes with a revised engineering math sequence, taught by the math department later in the curriculum, in concert with College and ABET requirements. The result has shifted the traditional emphasis on math prerequisite requirements to an emphasis on engineering motivation for math, with a "just-in-time" structuring of the required math sequence. This paper includes significant updates since the approach was last reported, including a multiyear assessment at Wright State University and expansion of the program to collaborating institutions.
In vitro enzymatic determination of the protein nutritional value and the amount of available lysine in extruded cereal-based products. (1985)

An in vitro method, using proteolytic enzymes for protein hydrolysis, was used to evaluate the effect of extrusion cooking on protein quality. The products studied were protein-enriched biscuits processed in a twin-screw extruder under different conditions. In the product processed at low temperature (170°C), the digestibility was comparable with that of the raw material. With increasing temperature (170 to 210°C), the in vitro availability of amino acids decreased. This decrease was most pronounced in the case of lysine, but the recovery of methionine, arginine, glycine, aspartic acid and aspargine was also affected. A loss of lysine, methionine and arginine could also be detected after acid hydrolysis. The total amount of lysine present in the raw material was not completely available, as judged from the in vitro assay as well as from balance experiments in rats. With increasing severity of heat treatment, the loss of biologically available lysine was more pronounced than the loss of total lysine. However, the loss of enzymatically available lysine was in good agreement with the results obtained in animal experiments. An increase in moisture content of the feed during processing, from 13 to 18%, improved the availability of lysine in particular.
Weighted Space-Variant Local Interconnections Based on Micro-Optic Components: Crosstalk Analysis and Reduction (1995)

(1) Introduction. The use of diffractive optical elements (DOE’s) and microlens arrays in optical interconnection systems can potentially provide high throughputs and small system volumes, using components that are amenable to automated design and mass production techniques. This paper considers fixed-weight neural network interconnections based on such components, and focuses on the realm of small system volumes and short propagation lengths (~1 mm) with potential for cascading into a compact, multilayer free-space system. We consider the space-variant interconnection system of Fig. 1, and achieve short propagation lengths by restricting each fanout pattern to a local neighborhood. The system uses an array of NxN sub-DOE's at the input plane to connect to an array of NxN detectors at the output plane. For this locally connected neural network interconnection, each sub-DOE stores one weighted fanout pattern that connects to MxM nearest neighbors in the output plane. The beam incident on each sub-DOE comes from a modulator or an emitter (not shown), which represents an interconnection input node (e.g., an output of a neuron unit). The optics of the interconnection system provides a Fourier transform (in magnitude) from each sub-DOE to the detector array, which serves as a set of neuron unit inputs. We constrain the sub-DOE spacing to be equal to the detector spacing to allow for use in multilayer systems. A globally connected space-variant system can be realized similarly by replacing the microlens array with a bulk lens and letting each input node connect to all output plane detectors [1,2]. The minimum propagation distance and system volume can be shown to be approximately proportional to M and N^M for the local system, and N and A3 for the global system, respectively. While the local system can be used in a smaller volume, its crosstalk levels can be high due to reconstruction noise (e.g. , diffraction orders outside of the local fanout neighborhood) of each sub-DOE. In this paper, we describe a crosstalk reduction method enabled by varying the mapping from reconstructed spot locations to detector locations. Several novel DOE designs for, and simulations of, local fixed-weight neural network interconnections are evaluated as a test of this method.
Low-temperature superfluid turbulence : experimental and numerical results (1998)

International audience
Production of Medium-Chain Length Polyhydroxyalkanoates by Pseudomonas citronellolis Grown in Apple Pulp Waste (2019)

Background and objective: Apple pulp waste generated by the fruit processing industry is a sugar-rich material with great potential to be used as a feedstock for production of value added microbial products. The aim of this work was to use this feedstock for the cultivation of Pseudomonas citronellolis and production of medium-chain-length polyhydroxyalkanoates, a natural elastomer. Material and methods: The solid fraction of the apple pulp waste was discarded and the soluble fraction, rich in fructose (17.7 g l-1), glucose (7.5 g l-1) and sucrose (1.2 g l-1), was used for the batch bioreactor cultivation of Pseudomonas citronellolis NRRL B-2504. Results and conclusion: Pseudomonas citronellolis reached a polymer content in the biomass of 30% wt and a volumetric productivity of 0.025 g l-1 h-1. The polymer was mainly composed of 3-hydroxydecanoate (68% mol) and 3-hydroxyoctanoate (22% mol), with minor contents of 3-hydroxydodecanoate (5% mol), 3-hydroxytetradecanoate (4% mol) and 3-hydroxyhexanoate (1% mol), and had a molecular weight of 3.7×105 Da. It presented glass transition and melting temperatures of -12 and 53°C, respectively, and a thermal degradation temperature of 296°C. The polymer’s films were dense, ductile and permeable to oxygen and carbon dioxide. These results demonstrated that apple pulp waste is a suitable feedstock for the production of a biopolymer with properties that render it a promising alternative to some synthetic petrochemical-derived polyesters. Conflict of interest: The authors declare no conflict of interest.
Coupled Non-Conforming Finite Element and Finite Difference Approximation Based on Laminate Extrapolation to Simulate Liquid Composite Molding Processes. Part II: Non-Isothermal Filling and Curing (2007)

Article Coupled Non-Conforming Finite Element and Finite Difference Approximation Based on Laminate Extrapolation to Simulate Liquid Composite Molding Processes. Part II: Non-Isothermal Filling and Curing was published on June 1, 2007 in the journal Science and Engineering of Composite Materials (volume 14, issue 2).
Multispectrum Signal Transmitters: Advances in Broadband High-Efficiency Power Amplifiers for Carrier Aggregated Signals (2014)

This article described recent advances in Doherty power amplifiers (DPAs) with extended bandwidth for use in future radio transmitters intended to support carrier aggregation signal transmission. It provided a review of several configurations of two-way (using symmetrical and asymmetrical drain supply voltages) and three-way DPAs. Furthermore, it identified various approaches to ensure proper load modulation over extended bandwidth by incorporating novel combining networks. It also discussed the additional challenges associated with the linearizability of DPAs when driven with interband aggregated signals.
Distinct functions of SR proteins in recruitment of U1 small nuclear ribonucleoprotein to alternative 5' splice sites. (1995)

Alternative splicing of precursor messenger RNAs (pre-mRNAs) is an important mechanism for the regulation of gene expression. The members of the SR protein family of pre-mRNA splicing factors have distinct functions in promoting alternative splice site usage. Here we show that SR proteins are required for the first step of spliceosome assembly, interaction of the U1 small nuclear ribonucleoprotein complex (U1 snRNP) with the 5' splice site of the pre-mRNA. Further, we find that individual SR proteins have distinct abilities to promote interaction of U1 snRNP with alternative 5' splice junctions. These results suggest that SR proteins direct 5' splice site selection by regulation of U1 snRNP assembly onto the pre-mRNA.
On discretizing the exponential on-off primary radio activities in simulations (2011)

In opportunistic spectrum access (OSA), secondary radios (SRs) are allowed to access the channel whenever primary radios (PRs) are not transmitting. The PR's spectrum activities are normally assumed to be a 2-state continuous Markov on-off process which can be modeled as two independent exponential random variables. On the other hand, some simulations prefer using a 2-state discrete Markov chain. As SRs periodically sense the channel to determine its availability before transmitting, maintaining the same false alarm and missed detection probabilities is necessary but still insufficient when discretizing the continuous PR on-off process. Earlier work has shown that type II missed detection error, which is a function of spectrum sensing period, occurs because PR, which is sensed to be inactive in the last sensing duration, can become active before the next spectrum sensing is performed. Hence, it is insufficient to simply perform simulation at the time stamp of spectrum sensing period as information about the type II missed detection error will be lost. This paper looks into the context of spectrum sensing on how we should select the time stamp of the simulation, i.e., the transition probabilities of the 2-state discrete Markov chain, so as to approximate the 2-state continuous Markov process without losing any valuable information. We first derive the expression for type II missed detection error based on the discrete PR on-off model. Then we present the method to decide the time stamp of the simulation so that type II missed detection probability is kept within a given error bound. The same approach can be generalized to other probability distributions of the spectrum activities.
Controlled release of β-estradiol from biodegradable microparticles within a silicone matrix (1994)

Novel, biodegradable controlled release systems were prepared from biodegradable microparticles of poly(lactic acid-co-glycolic acid) containing beta-estradiol in the presence or absence of silicone. The release behavior of beta-estradiol from free microparticles as well as from microparticles embedded within a silicone matrix was compared with the release behavior shown by nonencapsulated beta-estradiol within a silicone matrix. It was found that incorporating biodegradable microparticles within a silicone matrix lessens the initial burst of release often seen with these types of formulations and provides a controlled rate of drug release. In addition, the release rate of beta-estradiol from biodegradable microparticles within silicone is higher than for unencapsulated beta-estradiol in silicone. This type of formulation may be useful in a number of instances such as release of drugs from implants for which a simple drug-silicone formulation does not yield desired release behavior, formulations which are currently developed for microparticles but which may need to be removed if necessary, and implant formulations containing drugs which will not diffuse through silicone.
Developing, Implementing, and Adhering to a Code of Ethics (1992)

(1992). Developing, Implementing, and Adhering to a Code of Ethics. Hospitality & Tourism Educator: Vol. 4, No. 3, pp. 59-72.