gebhart/patrepeval huggingface dataset:
Genetic susceptibility to chronic trichuris muris induced experimental colitis: translation and relevance to human Crohn's disease (2011)

Introduction Unraveling the genetic architecture of complex traits presents a true challenge. The analysis of experimental models with strict phenotypic documentation and homology to human traits, alongside sensitive scientific methodologies, will facilitate future discoveries. Trichuris muris ( T muris ) induces chronic colitis in susceptible mouse strains, with previously described clinical, histological, and immunological commonalities to human Crohn's disease (CD). Conversely, resistant mouse strains exhibit acute infection, with quick and full recovery. Cross-breeding susceptible and resistant mice has permitted Quantitative Trait Loci (QTL) mapping, pertaining to chronic T muris inflammation. Aims (1.) Characterize the genetic basis of chronic Trichuris induced colitis, and identify biologically relevant susceptibility genes. (2) Correlate initial experimental findings to human CD genome sequence variation data. Methods An F2 inter-cross of resistant (BALB/c) and susceptible (AKR) mice were generated and infected with T muris (300 ova). Colonic and systemic phenotype was established (worm burden, histology, immune response), and QTL mapping performed. Genome-wide colonic transcriptional activity of parental strains was also determined (Affymetrix). Hypothesis-free in silico work-flow analysis identified candidate genes from the QTL and expression data. Genes lacking parental strain SNPs were excluded. Polymorphic QTL genes, with differential transcription were subsequently compared to experimental and CD data for potential homology. Results QTL associated with chronic T muris colitis susceptibility were identified on 7 murine chromosomes (Chr). 144 QTL-genes displayed parental strain SNPs and significant gene expression changes in chronic colitis (ANOVA, p&lt;0.05, expression fold-change ≤±1.4). QTL-Chr3 demonstrated overlap with published QTL of three unrelated experimental models of colitis. Of 33 potential QTL-Chr3 gene candidates, Ptpn22 and Fcgr1 display human and experimental homology. Additional transcribed polymorphic genes, central to biological (KEGG) pathways, were highlighted at this locus. Conclusion 7 QTL indicate susceptibility to chronic T muris colitis. Unbiased, systematic, reductionist analysis prioritised cis -QTL gene candidates. With experimental and human trait overlap, this model and methodology can inform the biology and outcome of transmural colonic inflammation. Positional, mechanistic pathway genes may thus be identified for translational studies.
AoA effects in outdoor V2I parking environments (2022)

As millimeter wave (mmWave) communication systems become an alternative solution to achieve higher transfer rates and lower latencies, they also induce channel degradations associated with their implementation. In this work, vehicular density impact over multipath contributions in a parking lot scenario is analyzed. The horizontal angle-of-arrival (AoA) information is presented and its relationship with five different vehicle densities is extracted. The angular dispersion is assessed by means of the AoA standard deviation and key representations of the channel characteristics are examined.
Aortic Arteriosclerosis in the Dog After Localized Aortic X-lrradiation (1962)

Localized segments of the abdominal aortas of 18 dogs were irradiated with 50-kv. x-rays in doses ranging from 1,500 to 5,500 r (at the ventral surface of the aorta), and were examined histologically at intervals ranging from 2 to 48 weeks after irradiation. Arteriosclerosis developed at the irradiated sites and was significantly more severe than that which occurred in nonirradiated control sites in the abdominal aorta. There was evidence that severity of arteriosclerosis increased with time following irradiation of the aorta. There was less pronounced arteriosclerosis after 3,000 to 5,500 r than after 1,500 to 2,500 r. It appeared that the larger doses of x-rays inhibited the full development of the late lesions, although presumably causing more initial primary damage. X-irradiation appeared to be followed by the development of arteriosclerotic lesions similar to those that occur naturally in old dogs. It is proposed that irradiation may selectively cause injury of the internal elastic membrane, and that this degenerative phenomenon is followed by the development of intimal fibrosis and plaque formation.
Radiation effects on GaAs/AlGaAs core/shell ensemble nanowires and nanowire infrared photodetectors (2017)

With the recent advances in nanowire (NW) growth and fabrication, there has been rapid development and application of GaAs NWs in optoelectronics. It is also of importance to study the radiation tolerance of optoelectronic nano-devices for atomic energy and space-based applications. Here, photoluminescence (PL) and time-resolved photoluminescence measurements were carried out on GaAs/AlGaAs core/shell NWs at room temperature before and after 1 MeV proton irradiation with fluences ranging from 1.0 × 10<sup>12</sup>-3.0 × 10<sup>13</sup> cm<sup>-2</sup>. It is found that the GaAs/AlGaAs core/shell NWs with smaller diameter show much less PL degradation compared with the ones with larger diameters. The increased radiation hardness is mainly attributed to the improvement of a room temperature dynamic-annealing mechanism near the surface of the NWs. We also found that the minority carrier lifetime is closely related to both the PL intensity and defect density induced by irradiation. Finally, GaAs/AlGaAs ensemble NW photodetectors operating in the near-infrared spectral regime have been demonstrated. The influence of proton irradiation on light and dark current characteristics also indicates that NW structures are a good potential candidate for radiation harsh-environment applications.
Stable Tubule Only Polypeptides (STOP) Proteins Co-Aggregate with Spheroid Neurofilaments in Amyotrophic Lateral Sclerosis (2003)

A major cytopathological hallmark of amyotrophic lateral sclerosis (ALS) is the presence of axonal spheroids containing abnormally accumulated neurofilaments. The mechanism of their formation, their contribution to the disease, and the possibility of other co-aggregated components are still enigmatic. Here we analyze the composition of such lesions with special reference to stable tubule only polypeptide (STOP), a protein responsible for microtubule cold stabilization. In normal human brain and spinal cord, the distribution of STOP proteins is uniform between the cytoplasm and neurites of neurons. However, all the neurofilament-rich spheroids present in the tissues of affected patients are intensely labeled with 3 different anti-STOP antibodies. Moreover, when neurofilaments and microtubules are isolated from spinal cord and brain, STOP proteins are systematically co-purified with neurofilaments. By SDS-PAGE analysis, no alteration of the migration profile of STOP proteins is observed in pathological samples. Other microtubular proteins, like tubulin or kinesin, are inconstantly present in spheroids, suggesting that a microtubule destabilizing process may be involved in the pathogenesis of ALS. These results indicate that the selective co-aggregation of neurofilament and STOP proteins represent a new cytopathological marker for spheroids.
Sizing Hybrid Energy Storage Systems for Distributed Power Systems under Multi-Time Scales (2018)

With the rapid development of industry, more fossil energy is consumed to generate electricity, which increases carbon emissions and aggravates the burden of environmental protection. To reduce carbon emissions, traditional centralized power generation networks are transforming into distributed renewable generation systems. However, the deployment of distributed generation systems can affect power system economy and stability. In this paper, under different time scales, system economy, stability, carbon emissions, and renewable energy fluctuation are comprehensively considered to optimize battery and super-capacitor installation capacity for an off-grid power system. After that, based on the genetic algorithm, this paper shows the optimal system operation strategy under the condition of the theoretical best energy storage capacity. Finally, the theoretical best capacity is tested under different renewable energy volatility rates. The simulation results show that by properly sizing the storage system’s capacity, although the average daily costs of the system can increase by 10%, the system’s carbon emissions also reduce by 42%. Additionally, the system peak valley gap reduces by 23.3%, and the renewable energy output’s fluctuation range and system loss of load probability are successfully limited in an allowable range. Lastly, it has less influence on the theoretical best energy storage capacity if the renewable energy volatility rate can be limited to within 10%.
Nickel Allergy—A Potential Cause of Razor Dermatitis (2014)

We discuss a case of razor-associated dermatitis to highlight a potential source of nickel exposure in allergic patients.
Comparison of closed loop vs. manual administration of propofol using the Bispectral index in cardiac surgery (2009)

The automated delivery of propofol using CLADS was safe, efficient and performed better than manual administration in open heart surgery.
Characterization of affective states by pupillary dynamics and autonomic correlates (2013)

With the recent advent of new recording devices and an easier access to signal processing tools, researchers are increasingly exploring and studying the Pupil Dilation (PD) signal. Recently, numerous studies pointed out the relations between PD dynamics and psychophysiological states. Although it is well known that PD is controlled by the Autonomic Nervous System (ANS), and ANS responses are related to emotional events/stimuli, the relationship between emotional states and PD is still an open issue. The aim of this study is to define the statistical properties of the PD signal, to understand its relation with ANS correlates such as Heart Rate Variability (HRV) and respiration (RESP), and to explore if PD could provide information for the evaluation of the psychophysiological response of ANS to affective triggering events. ECG, RESP, and PD data from 13 normal subjects were recorded during a memory recall paradigm, and processed with spectral and cross-spectral analysis. Our results demonstrate that variability indices extracted from fast PD oscillations, not observable through standard cardiorespiratory identification in the frequency domain, would be able to discern psychophysiological responses elicited by basic emotional stimuli. A strong linear coupling was found between the variables, due to the influence of RESP on both PD and HRV within the High Frequency (HF) band, from 0.15 to 0.45 Hz. Most importantly, our results point at PD features as possible candidates for characterizing basic emotional stimuli.
Platelet endothelial aggregation receptor-1 regulates bovine muscle satellite cell migration and differentiation via integrin beta-1 and focal adhesion kinase (2019)

PEAR1 is highly expressed at bovine MDSC differentiation. However, its biological function remains unclear. Western blotting results showed that PEAR1 increased between day 0 and day 2 of cell differentiation and decreased from day 3. Moreover, scratch test showed that wound healing rate increased after PEAR1 overexpression and decreased upon its suppression. Meanwhile, we found that, upon PEAR1 induction, both the expression of the focal adhesion-associated and MyoG, and the myotube fusion rate increased. However, when PEAR1 was suppressed, opposite results were obtained. Immunoprecipitation revealed an association between PEAR1 and ITGB1. Notably, inhibition of FAK and ITGB1 repressed cell differentiation. In conclusion, our study indicated that PEAR1 is involved in the regulation of bovine MDSC migration and differentiation.
DIURNAL CONSTANCY OF CORNEAL CURVATURE (1972)

The corneal curvature of four subjects was measured at 7 a.m., 11 a.m., 3 p.m., and 11 p.m. for three consecutive days. No pattern of diurnal variations was found, in sharp distinction to the changes occurring with contact lens wearers.
Non-thermal Plasma Treatment of Flowing Water: A Solution to Reduce Water Usage and Soil Treatment Cost without Compromising Yield (2016)

Water scarcity and drought have become increasingly larger problems because of the changing climate and exploding human population. According to the United Nations, by 2025, 2 million people will be affected by the lack of clean drinking water. Agriculture accounts for nearly 70% of the consumption of the Earth's freshwater supply. Hence, there is an increased effort to improve plant irrigation without compromising plant yield. The goal of this research study is to determine the effects of using non-thermal plasma technology (NTPT) on Arabidopsis thaliana water with non-thermal plasma (NTP) on A. thaliana plants showed that they could tolerate to control plants. The study also monitored molecular changes in the NTP-treated plants that could have contributed to the increased tolerance to drought.
The atypical chemokine receptor ACKR2 suppresses Th17 responses to protein autoantigens (2014)

Chemokine-directed leukocyte migration is a critical component of all innate and adaptive immune responses. The atypical chemokine receptor ACKR2 is expressed by lymphatic endothelial cells and scavenges pro-inflammatory CC chemokines to indirectly subdue leukocyte migration. This contributes to the resolution of acute inflammatory responses in vivo. ACKR2 is also universally expressed by innate-like B cells, suppressing their responsiveness to the non-ACKR2 ligand CXCL13, and controlling their distribution in vivo. The role of ACKR2 in autoimmunity remains relatively unexplored, although Ackr2 deficiency reportedly lessens the clinical symptoms of experimental autoimmune encephalomyelitis induced by immunization with encephalogenic peptide (MOG(35-55)). This was attributed to poor T-cell priming stemming from the defective departure of dendritic cells from the site of immunization. However, we report here that Ackr2-deficient mice, on two separate genetic backgrounds, are not less susceptible to autoimmunity induced by immunization, and in some cases develop enhanced clinical symptoms. Moreover, ACKR2 deficiency does not suppress T-cell priming in response to encephalogenic peptide (MOG(35-55)), and responses to protein antigen (collagen or MOG(1-125)) are characterized by elevated interleukin-17 production. Interestingly, after immunization with protein, but not peptide, antigen, Ackr2 deficiency was also associated with an increase in lymph node B cells expressing granulocyte-macrophage colony-stimulating factor (GM-CSF), a cytokine that enhances T helper type 17 (Th17) cell development and survival. Thus, Ackr2 deficiency does not suppress autoreactive T-cell priming and autoimmune pathology, but can enhance T-cell polarization toward Th17 cells and increase the abundance of GM-CSF(+) B cells in lymph nodes draining the site of immunization.
Measurement of trust in human-robot collaboration (2007)

We describe a Collaborative Performance Model that captures the critical performance attributes of the distinctive human-robotic decision and control environment. The literature and our initial experimental studies show that the element of trust in human-robot collaboration is an extremely important factor in the Performance Model, and accordingly we have focused much of our attention on deriving suitable and practical measures of this variable. In this paper we describe the formulation of a decision-analytical based measure of trust as well as the results of two initial experiments designed to examine trust in a tactical human-robot collaborative task performed in our new Mixed Initiative Team Performance Assessment System (MITPAS) simulation environment.
QM-Ergebnisdokumentation in der Katarakt-Chirurgie (2009)

Fragestellung: Dokumentationen von OP-Verläufen sind seit Generationen handschriftlich bzw. mit Computer unterstützen Schreibeprogrammen als OP-Berichte erstellt worden. Diese Dokumente waren und sind Grundlage für die spätere evtl. Beantwortung von juristischen Fragestellungen besonders nach komplizierten OP-Verläufen und -Ergebnissen. Eine Vielfalt von Lösungsansätzen kommt den gesetzlichen Forderungen nach, den OP-Verlauf und die OP-Ergebnisse in ihrer Gesamtheit so zu dokumentieren, dass sie statistisch aufgearbeitet werden können. Welche Lösungsansätze sind praktikabel? Mit welchen Parametern werden die Ergebnisse am besten abgebildet? Methode: Der Weg von standardisierten handschriftlichen OP-Berichten hin zu Datenbank basierten Erhebungen verschiedener Parameter wird beschrieben. Verschiedene praktizierte Ansätze werden vorgestellt. Die Abwägung von Aufwand, Sinnhaftigkeit und Validität wird diskutiert. Ergebnisse: Die Parameter Refraktions- und Visus-Änderungen, das Erreichen der Zielrefraktion, die Dokumentation von Komplikationen im Verhältnis zu präexistenten Problemen des Auges oder der allgemeinen Patientengesundheit werden erhoben. Aus einer Vielzahl an Daten müssen Kenngrößen extrahiert werden, die den OP-Verlauf und das OP-Ergebnis darstellen. Die Probleme des Organisations- und Zeitaufwands sind erheblich. Schlussfolgerung: Die Ergebnisdokumentation wird von den Medizinern per Gesetz gefordert. Erste Programme von Kassenärztlichen Vereinigungen bieten bei Lieferung der Daten auf elektronischem Weg eine wenn auch geringe, aber bessere Vergütung an. Die Lieferung dieser Daten werden Voraussetzung, um an Verträgen zwischen Ärzten und Krankenkassen teilzunehmen. Der Aufwand an Zeit und Geld für die Erbringung dieser Daten ist erheblich. Koordinierungen bundes- und europaweit sind erforderlich, welche Kenngrößen die Ergebnisse am effektivsten dokumentieren.
Prostaglandin E 2 induces fibroblast apoptosis by modulating multiple survival pathways (2009)

Although the lipid mediator prostaglandin E(2) (PGE(2)) exerts antifibrotic effects by inhibiting multiple fibroblast functions, its ability to regulate fibroblast survival is unknown. Here, we examined the effects of this prostanoid on apoptosis and apoptosis pathways in normal and fibrotic lung fibroblasts. As compared to medium alone, 24 h of treatment with PGE(2) increased apoptosis of normal lung fibroblasts in a dose-dependent manner (EC(50) approximately 50 nM), as measured by annexin V staining, caspase 3 activity, cleavage of poly-ADP-ribose polymerase, and single-stranded DNA levels. PGE(2) also potentiated apoptosis elicited by Fas ligand plus cycloheximide. These proapoptotic actions were dependent on signaling through the EP2/EP4 receptors and by downstream activation of both caspases 8 and 9. Silencing and gene deletion of PTEN demonstrated that the effects of PGE(2) involved decreased activity of the prosurvival molecule Akt. PGE(2) also down-regulated expression of survivin, an inhibitor of apoptosis, and increased expression of Fas. Fibroblasts from patients with pulmonary fibrosis exhibited resistance to the apoptotic effects of PGE(2). These findings show for the first time that, in contrast to its effects on many other cell types, PGE(2) promotes apoptosis in lung fibroblasts through diverse pathways. They provide another dimension by which PGE(2) may inhibit, and perhaps even reverse, fibrogenesis in patients with interstitial lung disease.
Substituted Hexahydrobenzo[f]thieno[c]quinolines as Dopamine D1-Selective Agonists:  Synthesis and Biological Evaluation in Vitro and in Vivo (1997)

A series of substituted 9,10-dihydroxyhexahydrobenzo[f]thieno[c]quinolines (TB[f]Q), varying with respect to the position of the thiophene relative to the benzo[f]quinoline core and the nature and position of the substituent on the thiophene, were prepared and evaluated for their affinity and selectivity for the dopamine D1-like receptor. The thieno[3,2-c]B[f]Q regioisomers bearing a small alky1 (C1-C3) substituent at the 2 position were potent (Ki < 20 nM) and selective (D2/D1 > 50) D1 agonists with close to full agonist activity (IA > 85%). The compounds were resolved and found to exhibit a high level of enantiospecificity in their interaction with the D1 receptor. Selected compounds were tested in vivo in the 6-OHDA rodent model of Parkinson's disease and for their liability to produce seizure-like activities in mice. (5aR)-trans-2-Propyl-4,5,5a,6,7, 11b-hexahydro-3-thia-5-azacyclopent-1-ena[c]phenanthrene-9,10-diol (5) emerged as the compound with the best overall in vivo profile in terms of potency (ED50 = 0.04 mumol/kg) and safety.
Phonetic Context Embeddings for DNN-HMM Phone Recognition (2016)

International audience
Preparative electrofocusing in agarose slab gels (1982)

Abstract A rapid preparative isoelectric focusing agarose slab gel technique that should prove to be valuable for the purification and characterization of clinically important macromolecules is described in this report. Up to 120 mg of plasma proteins have been focused in a 9.5 ml volume IsoGel agarose slab gel on a hydrophilic polyester plastic backing (GElBond) in 30 min or less. The agarose was permeable to proteins with molecular mass of 5–50 × 10 6 daltons and allowed recoveries of from 11–100 % depending on the proteins electrofocused. Proteins whose isoelectric points (pI) differed by 0.07 pH units will be separated by the described technique.
A comparative study of the electron trapping and thermal detrapping in SiO2 prepared by plasma and thermal oxidation (1992)

Preparation of silicon dioxide (SiO2) thin films by plasma anodization is a promising low temperature (≤600 °C) silicon oxidation technique. This paper investigates the electron trapping and thermal detrapping properties of the plasma grown oxide and compares them with those of the conventional thermal oxide. The avalanche electron injection measurement shows that the electron trapping in the plasma oxide is more severe. The two electron capture cross sections detected in the plasma oxide are of the order of 10−15 and 10−17 cm2, respectively. The former is absent in the thermal oxide and is a feature of oxides prepared at low temperature. The latter is also found in thermal oxide, but its chemical nature is different. Both of them are located near SiO2/silicon interface, indicating that they are related to the intermediate layer. The electron detrapping process in the plasma oxide is different from that in the thermal oxide and has a linear dependence on the logarithmic time. The detrapping is thermally activated with an activation energy of 0.63–0.75 eV. The above traps in plasma oxide can be removed by a high temperature (e.g., 960 °C) post-oxidation annealing (POA) in an inert ambient. After such a POA, the electron trapping in plasma oxide is similar to that in thermal oxides. Some speculation on the trap formation processes is included.