gebhart/patrepeval huggingface dataset:
Pyrazolono(3,4-d)pyrimidines. II. 6-Methylpyrazolono(3,4-d)pyrimidines and Some Reactions of Pyrazolono(3,4-d)pyrimidines1,2 (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPyrazolono(3,4-d)pyrimidines. II. 6-Methylpyrazolono(3,4-d)pyrimidines and Some Reactions of Pyrazolono(3,4-d)pyrimidines1,2MARTIN HAUSER, EARL PETERS, and HOWARD TIECKELMANNCite this: J. Org. Chem. 1961, 26, 2, 451–455Publication Date (Print):February 1, 1961Publication History Published online1 May 2002Published inissue 1 February 1961https://doi.org/10.1021/jo01061a043RIGHTS & PERMISSIONSArticle Views202Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (558 KB) Get e-Alerts Get e-Alerts
Adaptive Sweep Excitation of Optical Detection Magnetic Resonance Method for Measuring Magnetic Field in Diamond NV Center (2021)

Precise magnetic field measurement by using diamond nitrogen-vacancy (NV) center is a hot research direction in quantum detection field. At present, a main measurement method is continuous wave optical detection magnetic resonance (CW-ODMR). To obtain the complete ODMR curve required by this method, all frequency microwaves are needed to be traversed in a wide frequency band. However, in the subsequent calculation of the actual magnetic field, only a few narrow ODMR curves carry effective magnetic field information, and most of the frequency band curves brought by noise are meaningless. Using the traditional CW-ODMR method, each sweep point in the frequency band needs to use the scientific grade complementary metal oxide semiconductor (s-CMOS) camera to collect data, and there are a large amount of data and high computational complexity. In this paper, an adaptive sampling method with sweep step length is proposed. The identification thresholds of noise interval and signal interval are set, and their step conversion algorithms are used in different intervals. The adaptive step length sampling is used to replace the drawing of complete ODMR curve. The final simulation experiment shows that the method in this paper greatly reduces the number of frequency sweep points under the premise of ensuring the accuracy of magnetic field measurement.
Allocation of transmit power in Spatially-correlated dual-hop MIMO relay channels (2009)

This paper considers power allocation in spatially-correlated dual-hop multiple-input multiple-output (MIMO) relay channels under power constraint for each hop channel. The proposed scheme allocates the transmit power considering the spatial correlation as well as the average signal-to-noise ratio (SNR) of dual-hop MIMO relay channels. By means of upper-bound analysis, the proposed scheme can minimize the transmit power, while maximizing the end-to-end capacity of spatially-correlated MIMO channel. Simulation results show that the proposed scheme can provide performance enhancement over the SNR-based scheme in spatially-correlated channel environments.
Ionozyme: ionic liquids as solvent and stabilizer for efficient bioactivation of CO2 (2021)

The first developed ionozyme that combines a discovered novel FDHPa with a synergistic ionic microenvironment enables efficient bioactivation of CO 2 .
Relationship of eukaryotic DNA replication to committed gene expression: general theory for gene control (1991)

The historic arguments for the participation of eukaryotic DNA replication in the control of gene expression are reconsidered along with more recent evidence. An earlier view in which gene commitment was achieved with stable chromatin structures which required DNA replication to reset expression potential (D. D. Brown, Cell 37:359-365, 1984) is further considered. The participation of nonspecific stable repressor of gene activity (histones and other chromatin proteins), as previously proposed, is reexamined. The possible function of positive trans-acting factors is now further developed by considering evidence from DNA virus models. It is proposed that these positive factors act to control the initiation of replicon-specific DNA synthesis in the S phase (early or late replication timing). Stable chromatin assembles during replication into potentially active (early S) or inactive (late S) states with prevailing trans-acting factors (early) or repressing factors (late) and may asymmetrically commit daughter templates. This suggests logical schemes for programming differentiation based on replicons and trans-acting initiators. This proposal requires that DNA replication precede major changes in gene commitment. Prior evidence against a role for DNA replication during terminal differentiation is reexamined along with other results from terminal differentiation of lower eukaryotes. This leads to a proposal that DNA replication may yet underlie terminal gene commitment, but that for it to do so there must exist two distinct modes of replication control. In one mode (mitotic replication) replicon initiation is tightly linked to the cell cycle, whereas the other mode (terminal replication) initiation is not cell cycle restricted, is replicon specific, and can lead to a terminally differentiated state. Aberrant control of mitotic and terminal modes of DNA replication may underlie the transformed state. Implications of a replicon basis for chromatin structure-function and the evolution of metazoan organisms are considered.
Enantioselective Two-Dimensional High-Performance Liquid Chromatographic Determination of Amino Acids; Analysis and Physiological Significance of D-Amino Acids in Mammals (2014)

D-Amino acids are now increasingly recognized as physiologically functional molecules and biomarkers in mammals. However, the amounts of D-amino acids are extremely low in most cases, thus highly sensitive and selective analytical methods are practically essential. In the present review article, enantioselective two-dimensional high-performance liquid chromatographic (2D-HPLC) methods are introduced and their applications to the determination of D-amino acids in mammalian samples are described. For the sensitive determination, amino acid enantiomers are derivatized with 4-fluoro-7-nitro-2,1,3-benzoxadiazole (NBD-F), and are determined by a fluorescence detector. The 2D-HPLC system consists of the reversed-phase non-enantioselective, but chemoselective separation of NBD-amino acids in the first dimension, and the sequential chiral separation in the second dimension. By using the system, neuroactive D-amino acids (D-Ser and D-Ala) were determined in the brain of various mammalian species and the regulation of their intrinsic amounts are also demonstrated. The physiological and diagnostic meanings of the trace amounts of D-Ser are also discussed. The 2D-HPLC systems for the acidic D-amino acids (D-Asp and D-Glu), proline analogues (D-Pro, trans- and cis-4-hydroxy-D-Pro) and hydrophilic D-amino acids (D-Arg, D-Asn, D-Asp, D-Gln, D-Glu, D-His, D-Ser, D-allo-Thr and D-Thr) are also shown.
Investigation of terahertz pulse generation in semiconductors pumped at long infrared wavelengths (2022)

We present designs of semiconductor contact grating high energy terahertz pulse sources pumped by femtosecond pulses in the 1 to 5 µm wavelength range. Nearly wavelength-independent diffraction efficiencies as high as 69% and 75% in the <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"> <mml:mo>±</mml:mo> <mml:mn>1</mml:mn> </mml:math> st diffraction orders in the transverse electric field polarization state were predicted in GaAs and GaP, respectively, based on a rectangular grating. Numerical simulations—including, for the first time, to our knowledge, the effects of both a nonlinear refractive index and free carrier absorption—were performed to investigate the possible advantage of using longer pumping wavelengths to suppress the two- to seven-photon absorption. Conversion efficiency larger than 1.0% is predicted for both crystals. We also recognized that the nonlinear refractive index and the wavelength-dependent optical parametric amplifier efficiency can significantly reduce the overall terahertz generation efficiency; thus, optimum pump wavelengths exist for the highest conversion efficiency, which are 2 and <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"> <mml:mn>3</mml:mn> <mml:mspace width="thinmathspace"/> <mml:mspace width="thinmathspace"/> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:mtext>µ</mml:mtext> </mml:mrow> <mml:mi mathvariant="normal">m</mml:mi> </mml:math> for GaP and GaAs, respectively.
Perbezaan konsep diri akademik dalam kalangan pelajar aliran kebolehan tinggi, sederhana dan rendah (2007)

The role of attention and consistency with schema expectation in memory for objects in place were examined in one experiment. Forty participants were asked to study a picture of either the graduate student office or the preschool classroom, and either under full attention condition or under divided attention condition. Sixteen stimulus items, half consistent and half inconsistent with schema expectation about the room settings were placed throughout the room. Participants were later given a free recall test, followed by a same-changed recognition memory test immediately after that. The results show that participants remembered better under full attention condition than under divided attention condition. Items inconsistent with schema expectation were better recalled and recognized than items consistent with schema expectation both under full attention and divided attention conditions. These results support the findings on the consistency effect in some previous studies. More importantly, the present study reveals the influence of manipulation of attention on the consistency effect. The results show that consistency effect occurs in both conditions, with a greater effect reported under divided attention condition than under full attention condition. Reducing the participants’ attention increases the consistency effect.
Cultivation of three medicinal mushroom species on olive oil press cakes containing substrates (2014)

Olive oil press cakes (OOPC) represent a waste that has a negative impact on environment. OOPC have little or no use and because of that solutions for their alternative use are sought after. In our experiments we investigated substrate mixtures composed of different proportions of OOPC, wheat bran, crushed corn seeds and beech sawdust for cultivation of Ganoderma lucidum, Lentinula edodes and Grifola frondosa fruiting bodies. The increasing amount of OOPC in fruiting bodies cultivation substrates resulted in decreasing production of fruiting bodies. Results show, that although OOPC in small portion can be successfully used as a medicinal mushroom fruiting bodies cultivating substrate, their use is rational only, if no other substrate composing materials can be found or when OOPC usage solves the problem of its deposition.
Highly conductive and stretchable Ag nanowire/carbon nanotube hybrid conductors (2014)

Fabricating stretchable conductors through simple, cost-effective and scalable methods is a challenge. Here, we report on an approach used to develop nanowelded Ag nanowire/single-walled carbon nanotube (AgNW/SWCNT) hybrid films to be used as high-performance stretchable conductors. Plasmonic welding, which was done at the junctions of AgNWs in order to form hybrid AgNW/SWCNT conductors on an Ecoflex substrate, enabled excellent electrical and mechanical stability under large tensile strains of over 480% without the need to pre-strain. Furthermore, we demonstrate highly stretchable circuits that are used to power LED arrays. The LED arrays are formed using the plasmonic-welded AgNW/SWCNT/Ecoflex hybrid material, which demonstrates suitability for interconnector applications in flexible electronics.
Basal-like breast carcinomas: clinical outcome and response to chemotherapy (2006)

BLBCs are a distinct clinical and pathological entity, characterised by high nuclear grade, lack of hormone receptors and HER2 expression and a more aggressive clinical course. Standard adjuvant chemotherapy seems to be less effective in these tumours and new therapeutic approaches are indicated.
Charge Homogeneity in Synthetic Fluorohectorite (2001)

Due to phase separation in the silicate melt, the synthesis of fluorosmectites ([Na0.5]inter[Mg2.5Li0.5]oct[Si4]tetO10F2) from the melt without mechanical mixing yields an inhomogeneous material. Because of the solid solution capability of the 2:1 layer silicate structure, the nonuniformity in chemical and mineral composition inevitably will lead to fluorosmectites that adopt a range of charge densities. This will be detrimental to many possible applications due to the large influence of layer charge on the properties of clay minerals. The problem can be circumvented by rotating the crucible during synthesis in a horizontal mounting, which will continuously force mixing of the melt mechanically. The product obtained is homogeneous at all length scales as judged by chemical analysis and its uniform intracrystalline reactivity. Noteworthy is its tendency to form regularly interstratified intercalates of monolayers and bilayers upon alkylammonium exchange and of rectorite type phases upon partial K+ exchange. We expect that the two dissimilar types of galleries, which are stacked in a regularly alternating pattern, can be selectively addressedleading to interesting intercalation materials.
Characteristics and outcomes of patients screened for transcatheter mitral valve implantation: 1‐year results from the CHOICE‐MI registry (2022)

This registry included the largest number of patients treated with TMVI to date. TMVI with 10 dedicated devices resulted in predictable MR elimination and sustained functional improvement at 1 year. In TMVI-ineligible patients, bailout-TEER and high-risk surgery represented reasonable alternatives, while MT was associated with poor clinical and functional outcomes.
A compact 6-bit phase shifter in 0.35 µm SiGe BiCMOS technology (2016)

This paper presents a compact 14-18 GHz 6-bit digital phase shifter based on 0.35-μm SiGe BiCOMS technology. Three different topologies are adopted to achieve the desired phase shift with low insertion loss, accurate phase shifting and small parasitic amplitude modulation. The simulated performance of all 64 states of the phase shifter demonstrates an insertion loss of 9±0.9 dB and a RMS phase error <;4° with P <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1dB</sub> better than 11dBm. The input return loss and output return loss are better than -12 dB and -13.5dB over the 14-18 GHz frequency range respectively. And the chip size of this phase shifter is only 0.79×0.42 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> excluding PADs.
Early Routability Assessment in VLSI Floorplans: A Generalized Routing\n Model (2018)

Multiple design iterations are inevitable in nanometer Integrated Circuit\n(IC) design flow until desired printability and performance metrics are\nachieved. This starts with placement optimization aimed at improving\nroutability, wirelength, congestion and timing in the design. Contrarily, no\nsuch practice exists on a floorplanned layout, during the early stage of the\ndesign flow. Recently, STAIRoute \\cite{karb2} aimed to address that by\nidentifying the shortest routing path of a net through a set of routing regions\nin the floorplan in multiple metal layers. Since the blocks in hierarchical\nASIC/SoC designs do not use all the permissible routing layers for the internal\nrouting corresponding to standard cell connectivity, the proposed STAIRoute\nframework is not an effective for early global routability assessment. This\nleads to improper utilization of routing area, specifically in higher routing\nlayers with fewer routing blockages, as the lack of placement of standard cells\ndoes not facilitates any routing of their interconnections.\n This paper presents a generalized model for early global routability\nassessment, HGR, by utilizing the free regions over the blocks beyond certain\nmetal layers. The proposed (hybrid) routing model comprises of (a) the junction\ngraph model in STAIRoute routing through the block boundary regions in lower\nrouting layers, and (ii) the grid graph model for routing in higher layers over\nthe free regions of the blocks.\n Experiment with the latest floorplanning benchmarks exhibit an average\nreduction of $4\\%$, $54\\%$ and $70\\%$ in netlength, via count, and congestion\nrespectively when HGR is used over STAIRoute. Further, we conducted another\nexperiment on an industrial design flow targeted for $45nm$ process, and the\nresults are encouraging with $~3$X runtime boost when early global routing is\nused in conjunction with the existing physical design flow.\n
Search for Potential Amoebicides :III. Synthesis of Substituted 2-Hydrazino-5-Sulphazino Quinolines and Their Aniils (1979)

Department of Chemistry, Lucknow University, Lucknow. <em>Manuscript received 30 October 1976, revised 10 May 1978, accepted 22 August 1978</em> Some new substituted 2-hydrazino-5-sulphazino quinolines and a series of mails have been synthesised. All the anils were screened invitro for antiamoebic activity against <em>E. histolytica </em>(axenic). A majority of them were found to be considerably active.
Determination of Maximum Permissible Temperature Rise Considering Repetitive Over-Current Characteristics of YBCO Coated Conductors (2008)

Here we suggest stable maximum temperature criteria of YBCO coated conductors (CCs) considering degradation of YBCO by repetitive exposure to excessive temperature rise. Stable maximum permissible temperature was experimentally determined as the maximum temperature at which CC does not suffer from critical current degradation or burnout. By comparing various over-current characteristics with short-circuit characteristics in regards to the pattern of generated resistance and joule heating flux, maximum permissible temperature rise of YBCO CC in superconducting fault current limiter (SFCL) can be determined as 400 K. Our research is expected to provide rudimental basis for the temperature design of various superconducting power applications including SFCL.
Palladium‐Catalyzed Formation of C=C Bonds: A Regioselective Strategy for the Synthesis of 2‐Vinylfurans by 1,2‐H Shift of Palladium–Carbene Complexes (2013)

Abstract A convenient method to synthesize vinylfurans through a palladium‐catalyzed cyclization/1,2‐H shift sequence under mild conditions is described. This is an efficient strategy to synthesize 2‐vinylfurans from ene–yne ketones, and the corresponding products are obtained in good yields.
An outcome evaluation of an adult education and postsecondary alignment program: the accelerate New Mexico experience (2017)

Accelerate Math Camp, a federally-funded project of the Accelerate Technical Training and Job Placement Program (hereafter Accelerate New Mexico), has been carried out for three consecutive years (2011-2013) in six college campuses in northern New Mexico, in the Southwestern United States. Accelerate Math Camp has uniquely demonstrated statistically significant achievement of learning outcome goals by nontraditional students striving to enter or reenter a very competitive job market in STEM (Science, Technology, Engineering, and Math) related fields. Most remarkably, students of all backgrounds – men, women, racial and ethnic minorities, and majority students – have fared equally well in the 2013 Accelerate Math Camp. The program evaluation here reported found exceptionally positive results across the six program sites for student participants fitting every socio-demographic profile. This finding runs counter to the vast majority of published evaluations of similar programs – in the United States and Europe alike. These tend to show ambiguous learning outcomes at best, along with lower levels of accomplishment for women and minority students, both of whom are historically underrepresented in STEM fields. What limited findings of success may be reported occasionally in the academic and practitioner literature very often lack statistical rigor, and therefore generalizability and replicability. The present study runs counter to this trend, reporting historically unique, demonstrable success for this initiative, and providing a replicable model for aligned postsecondary education and employability programs.
Vers une imagerie optique du corps humain ? (2009)

L’imagerie optique médicale représente aujourd’hui un nouveau défi pour les physiciens : comment réaliser une biopsie optique, c’est-à-dire une coupe des tissus à différentes profondeurs, révélatrice du contraste optique local, alors que ces tissus sont très fortement diffusants ? Nous décrirons quelques approches dont certaines sont déjà utilisées à l’hôpital, d’autres prêtes à y être testées : en fonction de la profondeur les méthodes seront différentes, et il faut faire un compromis entre la taille des plus petits détails observables et la profondeur accessible.
Separation and Resolution of Methylcyclohexanones by Enclathration with Deoxycholic Acid (2019)

Deoxycholic acid (DCA) includes all the isomers of methylcyclohexanones (MCH). Competition experiments showed that the preference is 2MCH > 3MCH > 4MCH confirmed by crystal structure analysis, NMR, and thermal analysis. DCA resolves 2MCH, enclathrating the S-conformer, whereas 3MCH remains unresolved. However, in competition experiments of rac-2MCH/rac-3MCH, both guests are resolved yielding S-conformers, suggesting that 2MCH has a templating effect on the final structures. The activation energies of desolvation of the clathrates with 2MCH and 3MCH are similar (∼74 kJ/mol) but significantly lower for 4MCH (∼48 kJ/mol).
A chiral facially coordinated CuIIcomplex derived from a tridentate bis(benzimidazole) ligand: bis[(S,S)-1,2-dimethoxy-1,2-bis(1-methylbenzimidazol-2-yl)ethane]copper(II) bis(tetrafluoroborate) acetonitrile disolvate (2004)

Crystals of the chiral title salt, [Cu(C20H22N4O2)2](BF4)2·2C2H3N, contain Cu(L2)22+ cations separated by disordered tetra­fluoro­borate anions and by aceto­nitrile solvent mol­ecules. The ligands L2, (S,S)-1,2-di­methoxy-1,2-bis(1-methylbenzimidazol-2-yl)­ethane, coordinate Cu ions facially to yield a distorted and tetragonally elongated octahedral coordination geometry. Coordination affords V- or butterfly-shaped ligands, cations with the overall shape of the letter X, and seven-membered chelate rings which adopt distorted boat conformations. In the crystal structure, the cations form layers parallel to (001), interspersed with layers containing both tetra­fluoro­borate anions and aceto­nitrile mol­ecules. Ligands within a given cation, anions and solvate mol­ecules, and cations and anions, are linked by an extensive C—H⋯O and C—H⋯F hydrogen-bonding network. Additionally, cations within a given layer are linked by interionic head-to-tail π–π interactions between two benzimidalole fragments along the a cell direction and by edge-over-edge C—H⋯π overlap between the remaining two benz­imidazole fragments along the b cell direction.