gebhart/patrepeval huggingface dataset:
Extended High Frequency Brainstem Auditory Evoked Testing in Aging Canines (2021)

Presbycusis, or age-related hearing loss, has a common pattern of high frequency hearing loss that progresses as humans age. It is thought that canines experience a similar pattern of hearing loss as they age. Currently, there is little research on how aging impacts canine hearing acuity. This study was conducted to obtain data to determine if thresholds for the brainstem auditory evoked response (BAER) were different for two types of acoustic stimuli in older dogs. Ten dogs age nine or older were tested but data from two dogs were removed after the initial analysis. Threshold estimations were performed using clicks and 12kHz tonebursts. Stimuli were initially presented at a high intensity level of 92 dB peSPL. Wave V peaks were marked as the intensity decreased until peaks could no longer be identified; this was determined to be threshold. If no response was found at the initial presentation level of 92 dB peSPL, then intensity was increased to 102 dB peSPL. If no peak was identified at 102 dB peSPL, then testing was terminated and a no-response finding was recorded. For data analysis, 112 dB peSPL was used as threshold for the dogs with no responses. The results showed a statistically significant difference in the average thresholds for the click and 12kHz toneburst. The average threshold using clicks was 65.75 dB peSPL while the average threshold using 12kHz tonebursts was 92 dB peSPL. Since responses to clicks are thought to represent hearing sensitivity in the 2- 4kHz range and responses to 12kHz tonebursts represent higher frequency responses, the difference in hearing thresholds for a group of older canines might be an indication of a decline iv in auditory responses in higher frequency regions of the cochlea as canines age. It is possible hearing loss might be occurring within frequency regions above those assessed by click stimuli, and clinicians might want to consider incorporating high frequency toneburst testing into diagnostic BAER protocols in aging canines. More data on younger canines are needed before conclusions can be made about age-related hearing loss in canines.
Neural Model Reprogramming with Similarity Based Mapping for Low-Resource Spoken Command Recognition (2021)

In this study, we propose a novel adversarial reprogramming (AR) approach for low-resource spoken command recognition (SCR), and build an AR-SCR system. The AR procedure aims to modify the acoustic signals (from the target domain) to repurpose a pretrained SCR model (from the source domain). To solve the label mismatches between source and target domains, and further improve the stability of AR, we propose a novel similarity-based label mapping technique to align classes. In addition, the transfer learning (TL) technique is combined with the original AR process to improve the model adaptation capability. We evaluate the proposed AR-SCR system on three low-resource SCR datasets, including Arabic, Lithuanian, and dysarthric Mandarin speech. Experimental results show that with a pretrained AM trained on a large-scale English dataset, the proposed AR-SCR system outperforms the current state-of-the-art results on Arabic and Lithuanian speech commands datasets, with only a limited amount of training data.
OPPORTUNITIES AND CHALLENGES FOR TEACHING FRENCH IN CHINA (2015)

Although China is not in the francophone world, but it contributes significantly to the diffusion of the French language. Today, Its teaching of French has a history of more than 160 years, with a relatively complete system of courses. However, there are still many challenges for teaching French, which should be faced to have a better policy to teach this language.
The Sex Pheromone of the Mediterranean Flour Moth (1971)

Journal Article The Sex Pheromone of the Mediterranean Flour Moth Get access Yasumasa Kuwahara, Yasumasa Kuwahara Pesticide Research Institute College of Agriculture Kyoto University, Kyoto Search for other works by this author on: Oxford Academic Google Scholar Hidetoshi Hara, Hidetoshi Hara Pesticide Research Institute College of Agriculture Kyoto University, Kyoto Search for other works by this author on: Oxford Academic Google Scholar Shoziro Ishii, Shoziro Ishii Pesticide Research Institute College of Agriculture Kyoto University, Kyoto Search for other works by this author on: Oxford Academic Google Scholar Hiroshi Fukami Hiroshi Fukami Pesticide Research Institute College of Agriculture Kyoto University, Kyoto Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 35, Issue 3, 1 March 1971, Pages 447–448, https://doi.org/10.1080/00021369.1971.10859943 Published: 01 March 1971 Article history Received: 06 January 1971 Published: 01 March 1971
Polyethylenimine–polyepichlorohydrin interpolymer for chelating ion-exchange membrane (1979)

Polyethylenimine membranes consisting of linear polyethylenimine (PEI) and polyepichlorohydrin (PECH) were prepared by casting and heating an N,N-dimethylformamide solution of the two polymers under nitrogen at 100°C for 60 min. The membrane was also prepared by a heat-press method in a conventional manner. The cast membrane obtained was transparent. The membrane has a crosslinked structure due to the reaction between the secondary amino groups in PEI and the chloromethyl groups in PECH. Although a larger feed ratio of PEI/PECH gave membranes with a larger adsorption capacity for Cu2+ ions, the optimum ratio was 40/100 with respect to mechanical properties. A belt conveyor system using the PEI membrane was able to transport Cu2+ ions from one bath to another. In a diffusion dialysis against 1N HCl, the PEI membrane crosslinked rather tightly showed a specific ion-selective transfer character. For example, in Cu2+–Ca2+ system the permeability ratio Pcu/Pca was about 3.8. The selectivity arises from the difference between affinities (extractabilities) of PEI toward metal ions. The selectivity was changed depending on the pH value.
EasyTrack: Zero-Calibration Smart-Home Tracking System (2019)

Location-based services in household enable not only estimating activities but also detecting the accident location of residents including children, parents and elderly people. Furthermore, home management systems make use of location information of residents for encouraging residents to live comfortably in their own homes. Passive infrared binary motion sensors are widely used in home tracking systems because of low energy consumption and flexibility on deployment. However, it's hard for non-specialists like residents to manage such location information of sensors which are very important for tracking systems. To mitigate human efforts and errors, we propose a sensor localization method to automatically identify the location of multiple binary motion sensors in a house from the observed motion detection event sequences by binary sensors. The method finds the movement patterns and characteristics of sojourn time of residents to identify the rooms where those sensors are located as well as the proximity relations among sensors assisted by prior knowledge such as from floorplan. The experimental results in actual houses show that our method can estimate the location of sensors placed close to the anchor locations within a one-day observation, and the accuracy of our approach is above 80% after three-day observation.
Effects of stimulus and noise rate variability on speech perception by younger and older adults (2004)

The present experiments examine the effects of listener age and hearing sensitivity on the ability to understand temporally altered speech in quiet when the proportion of a sentence processed by time compression is varied. Additional conditions in noise investigate whether or not listeners are affected by alterations in the presentation rate of background speech babble, relative to the presentation rate of the target speech signal. Younger and older adults with normal hearing and with mild-to-moderate sensorineural hearing losses served as listeners. Speech stimuli included sentences, syntactic sets, and random-order words. Presentation rate was altered via time compression applied to the entire stimulus or to selected phrases within the stimulus. Older listeners performed more poorly than younger listeners in most conditions involving time compression, and their performance decreased progressively with the proportion of the stimulus that was processed with time compression. Older listeners also performed more poorly than younger listeners in all noise conditions, but both age groups demonstrated better performance in conditions incorporating a mismatch in the presentation rate between target signal and background babble compared to conditions with matched rates. The age effects in quiet are consistent with the generalized slowing hypothesis of aging. Performance patterns in noise tentatively support the notion that altered rates of speech signal and background babble may provide a cue to enhance auditory figure-ground perception by both younger and older listeners.
Biographical Sketch: Ruth Jackson, MD, FACS 1902-1994 (2010)

This biographical sketch on Ruth Jackson corresponds to the historic text, The Classic: The Cervical Syndrome, available at DOI 10.1007/s11999-010-1278-8 .
Die Bonding for a Nitride Light-Emitting Diode by Low-Temperature Sintering of Micrometer Size Silver Particles (2010)

Die-bonding for a nitride light-emitting diode (LED) by sintering of micrometer size Ag particles in air at 200°C was investigated. Micrometer size Ag particles absorb oxygen remarkably well at 200°C and above, and on sintering, they form a porous layer. The activating temperature of the sintering is in good agreement with the oxygen adsorption temperature. Sintering does not progress in the absence of oxygen. A reduction of thermal resistance and an improvement of reliability are achieved by the sintered layer as a die attach to a surface-mount-type LED. This mounting method is useful in the die bonding of electronic components, and is an alternative technique to high-temperature lead soldering.
Monocular Camera Localization in Prior LiDAR Maps with 2D-3D Line Correspondences (2020)

Light-weight camera localization in existing maps is essential for vision-based navigation. Currently, visual and visual-inertial odometry (VO\&amp;VIO) techniques are well-developed for state estimation but with inevitable accumulated drifts and pose jumps upon loop closure. To overcome these problems, we propose an efficient monocular camera localization method in prior LiDAR maps using direct 2D-3D line correspondences. To handle the appearance differences and modality gaps between LiDAR point clouds and images, geometric 3D lines are extracted offline from LiDAR maps while robust 2D lines are extracted online from video sequences. With the pose prediction from VIO, we can efficiently obtain coarse 2D-3D line correspondences. Then the camera poses and 2D-3D correspondences are iteratively optimized by minimizing the projection error of correspondences and rejecting outliers. Experimental results on the EurocMav dataset and our collected dataset demonstrate that the proposed method can efficiently estimate camera poses without accumulated drifts or pose jumps in structured environments.
Novel High-throughput Approach for Purification of Infectious Virions (2016)

Viruses are extensively studied as pathogens and exploited as molecular tools and therapeutic agents. Existing methods to purify viruses such as gradient ultracentrifugation or chromatography have limitations, for example demand for technical expertise or specialized equipment, high time consumption, and restricted capacity. Our laboratory explores mutations in oncolytic reovirus that could improve oncolytic activity, and makes routine use of numerous virus variants, genome reassortants, and reverse engineered mutants. Our research pace was limited by the lack of high-throughput virus purification methods that efficiently remove confounding cellular contaminants such as cytokines and proteases. To overcome this shortcoming, we evaluated a commercially available resin (Capto Core 700) that captures molecules smaller than 700 kDa. Capto. Core 700 chromatography produced virion purity and infectivity indistinguishable from CsCl density gradient ultracentrifugation as determined by electron microscopy, gel electrophoresis analysis and plaque titration. Capto Core 700 resin was then effectively adapted to a rapid in-slurry pull-out approach for high-throughput purification of reovirus and adenovirus. The in-slurry purification approach offered substantially increased virus purity over crude cell lysates, media, or high-spin preparations and would be especially useful for high-throughput virus screening applications where density gradient ultracentrifugation is not feasible.
Supercharging Prions via Amyloid‐Selective Lysine Acetylation (2021)

Abstract Repulsive electrostatic forces between prion‐like proteins are a barrier against aggregation. In neuropharmacology, however, a prion's net charge ( Z ) is not a targeted parameter. Compounds that selectively boost prion Z remain unreported. Here, we synthesized compounds that amplified the negative charge of misfolded superoxide dismutase‐1 (SOD1) by acetylating lysine‐NH 3 + in amyloid‐SOD1, without acetylating native‐SOD1. Compounds resembled a “ball and chain” mace: a rigid amyloid‐binding “handle” (benzothiazole, stilbene, or styrylpyridine); an aryl ester “ball”; and a triethylene glycol chain connecting ball to handle. At stoichiometric excess, compounds acetylated up to 9 of 11 lysine per misfolded subunit (Δ Z fibril =−8100 per 10 3 subunits). Acetylated amyloid‐SOD1 seeded aggregation more slowly than unacetylated amyloid‐SOD1 in vitro and organotypic spinal cord (these effects were partially due to compound binding). Compounds exhibited reactivity with other amyloid and non‐amyloid proteins (e.g., fibrillar α‐synuclein was peracetylated; serum albumin was partially acetylated; carbonic anhydrase was largely unacetylated).
A practical guide to data management and sharing for biomedical laboratory researchers (2023)

Effective data management and sharing have become increasingly crucial in biomedical research; however, many laboratory researchers lack the necessary tools and knowledge to address this challenge. This article provides an introductory guide into data management, and the importance of FAIR (Findable, Accessible, Interoperable, and Reusable) data-sharing principles for laboratory researchers. We explore the advantages of implementing organized data management strategies and introduce key concepts such as data standards, data documentation, and the distinction between machine and human-readable data formats. Furthermore, we offer practical guidance for creating a data management plan and establishing efficient data workflows within the laboratory setting, suitable for labs of all sizes. This includes an examination of requirements analysis, the development of a data dictionary for routine data elements, the implementation of unique subject identifiers, and the formulation of standard operating procedures (SOPs) for seamless data flow. To aid researchers in implementing these practices, we present a simple organizational system as an illustrative example, which can be tailored to suit individual needs and research requirements.<br> By presenting a user-friendly approach, this article serves as an introduction to the field of data management and offers a practical guide to help researchers effortlessly meet the common data management and sharing mandates rapidly becoming prevalent in biomedical research.
The Melting and Crystallization Kinetics of Hydrogenated Polybutadiene (1988)

Abstract : The overall isothermal crystallization kinetics of a series of hydrogenated polybutadienes having narrow molecular weight and composition distributions have been studied using calorimetric and dilatometric techniques. In addition to the general inquiry into the crystallization kinetics and mechanisms of such well-constituted and characterized samples, the study was also promoted by the unusual melting temperatures and levels of crystallinity that are observed with molecular weight. The hydrogenated polybutadienes can be considered as copolymers with a random copolymers because of the narrow molecular weight and composition distribution. Special attention has been given to the influence of molecular weight and co-unit content on the crystallization process and to the long-time crystallization rate. (JES)
Assessment of Genotypic Diversity of Antibiotic-Producing Pseudomonas Species in the Rhizosphere by Denaturing Gradient Gel Electrophoresis (2005)

The genotypic diversity of antibiotic-producing Pseudomonas spp. provides an enormous resource for identifying strains that are highly rhizosphere competent and superior for biological control of plant diseases. In this study, a simple and rapid method was developed to determine the presence and genotypic diversity of 2,4-diacetylphloroglucinol (DAPG)-producing Pseudomonas strains in rhizosphere samples. Denaturing gradient gel electrophoresis (DGGE) of 350-bp fragments of phlD, a key gene involved in DAPG biosynthesis, allowed discrimination between genotypically different phlD(+) reference strains and indigenous isolates. DGGE analysis of the phlD fragments provided a level of discrimination between phlD(+) genotypes that was higher than the level obtained by currently used techniques and enabled detection of specific phlD(+) genotypes directly in rhizosphere samples with a detection limit of approximately 5 x 10(3) CFU/g of root. DGGE also allowed simultaneous detection of multiple phlD(+) genotypes present in mixtures in rhizosphere samples. DGGE analysis of 184 indigenous phlD(+) isolates obtained from the rhizospheres of wheat, sugar beet, and potato plants resulted in the identification of seven phlD(+) genotypes, five of which were not described previously based on sequence and phylogenetic analyses. Subsequent bioassays demonstrated that eight genotypically different phlD(+) genotypes differed substantially in the ability to colonize the rhizosphere of sugar beet seedlings. Collectively, these results demonstrated that DGGE analysis of the phlD gene allows identification of new genotypic groups of specific antibiotic-producing Pseudomonas with different abilities to colonize the rhizosphere of sugar beet seedlings.
Unraveling the regulation of floral fragrance biosynthesis (2011)

Floral volatiles are biologically and economically important plant derived chemical compounds. In petunia, floral volatile benzenoid/phenylpropanoid (FVBP) biosynthesis is controlled spatially, developmentally, and hormonally at molecular, metabolic, and biochemical levels. Over the last years, numerous genes have been shown to encode proteins that either directly catalyze a biochemical reaction yielding FVBP compounds, or are involved in metabolite flux prior to the formation of FVBP compounds. This FVBP gene network is specifically and coordinately transcribed. Multiple R2R3-MYB transcription factors are involved in the regulation of genes in the core metabolic pathways leading to a very unique mixture of emitted floral volatiles. The molecular puzzle is not complete, since the functions of the few FVBP transcription factors identified to date do not fully explain the transcriptional regulation of the entire gene network.
Dynamic Maps for Exploring and Browsing Shapes (2013)

Abstract Large datasets of 3D objects require an intuitive way to browse and quickly explore shapes from the collection. We present a dynamic map of shapes where similar shapes are placed next to each other. Similarity between 3D models exists in a high dimensional space which cannot be accurately expressed in a two dimensional map. We solve this discrepancy by providing a local map with pan capabilities and a user interface that resembles an online experience of navigating through geographical maps. As the user navigates through the map, new shapes appear which correspond to the specific navigation tendencies and interests of the user, while maintaining a continuous browsing experience. In contrast with state of the art methods which typically reduce the search space by selecting constraints or employing relevance feedback, our method enables exploration of large sets without constraining the search space, allowing the user greater creativity and serendipity. A user study evaluation showed a strong preference of users for our method over a standard relevance feedback method.
Nonlinear cavity optomechanics with nanomechanical thermal fluctuations (2017)

Although the interaction between light and motion in cavity optomechanical systems is inherently nonlinear, experimental demonstrations to date have allowed a linearized description in all except highly driven cases. Here, we demonstrate a nanoscale optomechanical system in which the interaction between light and motion is so large (single-photon cooperativity C<sub>0</sub>≈10<sup>3</sup>) that thermal motion induces optical frequency fluctuations larger than the intrinsic optical linewidth. The system thereby operates in a fully nonlinear regime, which pronouncedly impacts the optical response, displacement measurement and radiation pressure backaction. Specifically, we measure an apparent optical linewidth that is dominated by thermo-mechanically induced frequency fluctuations over a wide temperature range, and show that in this regime thermal displacement measurements cannot be described by conventional analytical models. We perform a proof-of-concept demonstration of exploiting the nonlinearity to conduct sensitive quadratic readout of nanomechanical displacement. Finally, we explore how backaction in this regime affects the mechanical fluctuation spectra.
Simulation Verification and Validation by Dynamic Policy Enforcement (2005)

This paper presents a new verification and validation (V&V) technique for simulation using dynamic policy enforcement. Constraints are formally specified as policies, and they will be used to check whether simulation satisfies these policies at runtime. This paper also proposes a development framework where policies are developed along with system development and V&V. Once policies are extracted from requirements and specified in a policy specification language, the rest of the development work is automatically performed by the tools in the framework. Both security requirements and functional requirements can be specified as policies and dynamically enforced during the simulation. An automated tool is available for policy specification and enforcement, and it is fully integrated with the simulation infrastructure. This paper also presents a sample system that is modeled and simulated, and policies are used to verify and validate the system model. The paper also discusses the overhead imposed to perform this kind of automated policy-based V&V compared to the hard-coded implementation of the same approach.
Non-Destructive Techniques Based on Eddy Current Testing (2011)

Non-destructive techniques are used widely in the metal industry in order to control the quality of materials. Eddy current testing is one of the most extensively used non-destructive techniques for inspecting electrically conductive materials at very high speeds that does not require any contact between the test piece and the sensor. This paper includes an overview of the fundamentals and main variables of eddy current testing. It also describes the state-of-the-art sensors and modern techniques such as multi-frequency and pulsed systems. Recent advances in complex models towards solving crack-sensor interaction, developments in instrumentation due to advances in electronic devices, and the evolution of data processing suggest that eddy current testing systems will be increasingly used in the future.