gebhart/patrepeval huggingface dataset:
Generalized Source method for ultrafast rigorous modeling of pixelated DOEs with sub-wavelength feature size (2014)

International audience
Application of Case Classification in Healthcare Quality Assessment in China (2012)

The purpose of this study was to build a healthcare quality assessment system with disease category as the basic unit of assessment based on the principles of case classification, and to assess the quality of care in a large hospital in Shanghai. Using the Delphi method, four quality indicators were selected. The data of 124,125 patients discharged from a large general hospital in Shanghai, from October 1, 2004 to September 30, 2007, were used to establish quality indicators estimates for each disease. The data of 51,760 discharged patients from October 1, 2007 to September 30, 2008 were used as the testing sample, and the standard scores of each quality indicator for each clinical department were calculated. Then the total score of various clinical departments in the hospital was calculated based on the differences between the practical scores and the standard. Based on quality assessment scores, we found that the quality of healthcare in departments of thyroid and mammary gland surgery, obstetrics and gynaecology, stomatology, dermatology, and paediatrics was better than in other departments. Implementation of the case classification for healthcare quality assessment permitted the comparison of quality among different healthcare departments.
Structure-function relationships for the interleukin 2 receptor: location of ligand and antibody binding sites on the Tac receptor chain by mutational analysis. (1988)

The Tac protein plays a role in high- and low-affinity interleukin 2 (IL-2) receptors. A mutational survey of this molecule identified several small segments in which the binding of IL-2 was particularly sensitive to amino acid substitutions. Two of the segments (residues 1-6 and 35-43) located in the exon 2-encoded region of the molecule overlapped the apparent binding sites of three monoclonal antibodies (anti-Tac, GL439, and H31) that block high- and low-affinity Tac-IL-2 interactions, thus supporting the hypothesis that these segments of the protein are at or near sites of receptor-ligand contact. In contrast, the apparent binding sites of antibodies (Hiei and H47) that selectively inhibit high-affinity IL-2 binding were mapped to a distinct location (residues 158-160) within the region encoded by exon 4 of the Tac gene. Since high-affinity receptors consist of a heterodimer of Tac and a second ligand-binding protein (p70), this portion of the Tac molecule may be involved in the interaction between the two receptor subunits. As expected, the binding sites of noninhibitory antibodies (7G7/B6, residues 140-144; H48, residues 170-211) did not overlap those segments in which IL-2-binding mutants were observed. These results provide a preliminary correlation of structure and function for the Tac protein that should prove useful in evaluating detailed models of the IL-2-receptor complex.
Beta kyseliny chmele, význam a využití Hop beta acids: Properties, Significance and Utilization (2014)

Pěstovani chmele (Humulus lupulus L.) ma dlouhou historii. Chmel jako lecivou rostlinu zmiňuje řimský historik Plinius v 1. stoleti př. n. l. a od 8. stoleti byl pěstovan zejmena v okoli klasterů. Ve středověku se chmel zacal použivat při vařeni piva jako konzervacni a hořcici agens. Od te doby je chmel zakladni surovinou při výrobě piva, asi 95 % celosvětove produkce chmele je urceno pro pivovarske ucely (Biendl a Pinzl, 2007), zbytek je z velke casti použit pro výrobu fytomedikamentů a přirodnich potravinových doplňků. Z taxonomickeho hlediska rod Humulus patři celedi Cannabaceae z řadu Urticales, ale v roce 2003 byl zahrnut do řadu Rosales (Bremer et al., 2003). Rod Humulus zahrnuje druhy Humulus japonicus Siebold a Zucc., Humulus yunnanensis Hu, Humulus lupulus L., posledně jmenovaný je teměř výhradně pěstovan pro pivovarske ucely. Zrale chmelove hlavky obsahuji řadu sekundarnich metabolitů, pryskyřice, silice a polyfenolove latky (tab. 1), jejichž empiricky zjistěne digestivni, zklidňujici a antisepticke působeni bylo využivano v přirodni medicině a popsano v řadě herbařů (Biendl, 2009). V poslednich 10–15 letech je provaděn intenzivni biomedicinský výzkum s cilem zjistit bioaktivni latky v chmelu a objasnit zakladni molekularni mechanismy, kterými tyto latky působi. Znacna poBeta kyseliny chmele, význam a využiti
Analysis of DBE grown GaInAsP/InP heterostructures for 1.55 mu m lasers (2002)

The quality of GaInAsP/InP heterostructures grown by chemical beam epitaxy is analyzed using the light-current characteristics of board area lasers. The optical scattering linear coefficient ( alpha s) and the effective radiative coefficient (B/sub eff/) are calculates from the comparison of experimental data with a theoretical model. The low value of alpha s (9 cm/sup -1/) indicated a low roughness of the interfaces. The value of B/sub eff/ is found to be comparable with those obtained for heterostructures grown with other techniques.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Nonlinear enhancement in a coherently excited microcavity (Poster) (2015)

International audience
Room temperature Fe2+:ZnS laser (2015)

Characteristics of a laser on polycrystalline ZnS:Fe<sup>2+</sup> subjected from two sides to diffuse doping at room temperature are investigated. The sample was pumped by a non-chain electrodischarge HF laser with the radiation pulse FWHM duration of ~140 ns. The diameter of pumping radiation spot on the surface of crystal was 3.8 mm. Further increase of the size of pumping spot was limited by parasitic generation arising due to a high concentration of Fe ions in the near-surface layer of sample at a relatively small depth of doping (short length of active medium). The output energy of ZnS:Fe<sup>2+</sup> laser was 25.5 mJ at the slope efficiency with respect to the energy absorbed in the crystal of 20%. Characteristics of lasers on polycrystalline ZnS:Fe<sup>2+</sup> and ZnSe:Fe<sup>2+</sup> have been compared in equal pumping conditions. The slope efficiency of ZnSe:Fe<sup>2+</sup> laser was 34%. At equal pumping energy absorbed in the samples, the duration of ZnSe:Fe<sup>2+</sup> laser radiation pulse was longer than that of ZnS:Fe<sup>2+</sup> laser. Possibilities of increasing the efficiency of ZnS:Fe<sup>2+</sup> laser operation at room temperature by improving the technology of sample manufacturing and reducing the duration of pumping pulse are discussed.
Influence of the Benzoquinone Sorption on the Structure and Electrochemical Performance of the MIL-53(Fe) Hybrid Porous Material in a Lithium-Ion Battery (2009)

Among the metal-organic frameworks (MOFs), MIL-53(Fe) or FeIII(OH)0.8F0.2[O2C−C6H4−CO2] was the first ever reported member to reversibly insert Li+ electrochemically. A variety of electroactive sorbents has been investigated in an attempt to increase its electrochemical capacity vs Li+/Li0. Here, we describe the synthesis and characterization of a new composite hybrid material involving MIL-53(Fe) as the host for the guest electroactive 1,4-benzoquinone molecule in a 1:1 molar ratio, using complementary high-resolution X-ray diffraction (XRD), differential scanning calorimetry (DSC), and magic angle spinning nuclear magnetic resonance (MAS NMR) measurements. Its room-temperature structure has been solved and shows that the quinone molecules are located within the channels nearly parallel to each other, and to the benzene rings of the skeleton, in order to maximize π−π interactions. When heated in a sealed container, a flip-flop reorganization of the quinone molecules occurred above 140 °C, whereas in an open environment, desorption of the quinone was shown near 120 °C giving rise to a new phase having solely 0.5 quinone molecules/MIL-53(Fe) formula unit. Enhancement of the electrochemical performances, due to the redox properties of the quinone molecules, was observed during the first 2 cycles. An exchange between both the quinone and the electrolyte molecules is proposed to account for the capacity decay in subsequent cycles.
Cotton Germplasm Collection of Uzbekistan (2014)

Cultivated cotton (Gossypium spp.) is the main source of natural fiber and oilseed as well as one of the most important crops for bioenergy production. Although cotton is native to the tropics and subtropics, it is naturally cultivated in more than 80 countries. The Uzbekistan cotton germplasm collection is one of the largest among worldwide collections, representing accessions and species not only with wide geographic and ecological niches but also with large amplitude of morphobiological and genetic diversity. More than 40 Ato G and K-genomes of wild Gossypium species as well as ~7,500 cotton accessions are preserved in the Institute of Genetics and Plant Experimental Biology at the Academy of Sciences of Uzbekistan (IGPEB). There are a number of lines and cultivars with useful agronomic traits (early maturing, long fiber, high yield, disease tolerant, etc.) that have been developed using Uzbek cotton germplasm resources. A history of the collection development, maintenance, management and problems of ex situ conservation as well as utilization of germplasm resources are reviewed in this paper. _____________________________________________________________________________________________________________
Fabrication of Thin-Film, Flexible, and Transparent Electrodes Composed of Ruthenic Acid Nanosheets by Electrophoretic Deposition and Application to Electrochemical Capacitors (2006)

Ruthenic acid nanosheet colloids were prepared by dispersing a tetrabutylammonium–ruthenic acid intercalation compound in acetonitrile or -dimethylformamide. Nanosheet electrodes were fabricated on gold, indium-tin oxide (ITO)-coated glass, and ITO-coated poly(ethylene terephthalate) (PET) electrodes by electrophoretic deposition using these colloids. Transparent or flexible electrodes could be fabricated by using ITO electrodes as the substrate. The deposited amount of material could easily be controlled by the extent of deposition, which was confirmed from the linear increase in specific capacitance as a function of deposition time. The ruthenic acid nanosheet electrodes using Au substrates exhibited gravimetric capacitance of . Specific capacitance of was achieved at a scan rate of with a film deposited at for .
Poly(aryleneethynylene) Type Polymers Containing a Ferrocene Unit in the π-Conjugated Main Chain. Preparation, Optical Properties, Redox Behavior, and Mössbauer Spectroscopic Analysis (1997)

Palladium-catalyzed polycondensation between diiodoferrocenes (1,1‘-diiodoferrocene and 1,6-diiodo-1‘,6‘-biferrocene) and diethynyl aromatic compounds HC⋮CArC⋮CH (e.g., 2,5-diethynylpyridine and 2,5-diethynyl-3-hexylthiophene) gives poly(aryleneethynylene) (PAE) type polymers containing the ferrocene unit in the π-conjugated main chain. The prepared polymers include (FcC⋮CPhC⋮C)n, PAE-Fc-1, (FcC⋮CPyC⋮C)n, PAE-Fc-2, and (FcC⋮ChexThC ⋮C)n, PAE-Fc-3 (Fc = 1,1‘-ferrocenylene; Ph = p-phenylene; Py = pyridine-2,5-diyl; hexTh = 3-hexylthiophene-2,5-diyl). 1H-NMR and IR spectra of the polymers are reasonable for their structures. The PAE type polymer containing the pyridine unit (PAE-Fc-2) is soluble in formic acid, and the polymer containing the hexylthiophene unit (PAE-Fc-3) is soluble in common organic solvents such as CHCl3, THF, and benzene. UV−visible spectra of the polymers exhibit a main π−π* absorption peak at about 330 nm and a d−d absorption peak at about 450 nm. The cyclic voltammogram of the polymers in a CH3CN/CH2Cl2 solution shows a reversible Fe(II) ⇄ Fe(III) redox cycle at about 0.25 V vs Ag/Ag+, and the redox peaks are broadened compared with those of low-molecular-weight ferrocenes. Exchange of electrons along the main chain is considered to be the origin of the broadening. The polymers themselves are insulating, however, they are converted into semiconducting materials with conductivity of 10-7 to 10-4 S cm-1 by formation of adducts with iodine. Mössbauer spectra of the polymers reveal oxidation of Fe(II) in the ferrocene unit of PAE-Fc-1 to Fe(III), and the ease of the oxidation reflects the electronic properties of the polymer.
Auguralia und Verwandtes. By Edwin Flinck. Crown octavo. Pp. 74. Helsingfore: Drucherei der Finnischen Litteratur-Gesellschaft, 1921. (1922)

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Patterns of Cytomegaloviral Complement-Fixing Antibody Activity: A Longitudinal Study of Blood Donors (1973)

Journal Article Patterns of Cytomegaloviral Complement-Fixing Antibody Activity: A Longitudinal Study of Blood Donors Get access Joseph L. Waner, Joseph L. Waner From the Department of Tropical Public Health, Harvard School of Public Health, and the Transfusion Service, Children's Hospital Medical Center, Boston, Massachusetts Search for other works by this author on: Oxford Academic PubMed Google Scholar Thomas H. Weller, Thomas H. Weller From the Department of Tropical Public Health, Harvard School of Public Health, and the Transfusion Service, Children's Hospital Medical Center, Boston, Massachusetts Search for other works by this author on: Oxford Academic PubMed Google Scholar Sherwin V. Kevy Sherwin V. Kevy From the Department of Tropical Public Health, Harvard School of Public Health, and the Transfusion Service, Children's Hospital Medical Center, Boston, Massachusetts Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Infectious Diseases, Volume 127, Issue 5, May 1973, Pages 538–543, https://doi.org/10.1093/infdis/127.5.538 Published: 01 May 1973 Article history Received: 08 September 1972 Revision received: 24 November 1972 Published: 01 May 1973
Epoxy hydrogels as sensors and actuators (2007)

Most hydrogel actuators and sensors are made via acrylate polymerizations. Because these chain reactions are inhibited by oxygen, it is difficult to prepare thin films or dots with good control. Epoxy curing chemistry is much less sensitive to experimental conditions. We have previously shown that hydrogels formed from reaction between water-soluble amines and epoxides can be readily printed. If the gel is filled with conducting carbon at a level close to the percolation threshold, the resistance changes as water is taken up or removed from the gel. In particular, a pH decrease results in ionization of amine groups and drives swelling of the gel. By incorporating an enzyme, such as glucose oxidase, that releases hydrogen ions when its substrate is present, a resistance change can be used to measure substrate concentrations. These gels also respond to stress with a change in resistance. By making the gel the anode or cathode of an electrolytic cell, they can also be formed as actuators that expand or contract as the pH changes locally. Epoxy chemistry has been little explored for gels. It is very versatile and could be used to make a wide range of gel composites with one or more phases, varying water contents, varying functional groups and a range of electrical conductivity.
Detailed Kinetic Modeling of Low-Temperature Heat Release for PRF Fuels in an HCCI Engine (2009)

&lt;div class="htmlview paragraph"&gt;Now more than ever, the increasing strictness of environmental regulation and the stronger need of higher efficiency standards are pushing for the development of cleaner and energy-efficient powertrains. HCCI engines are suitable candidates to achieve these objectives. Understanding the autoignition process and how it is affected by operating conditions is central to the development of these engines. In addition to experiments, detailed kinetic modeling represents a very effective tool for gaining deeper insight into the fundamentals of HCCI autoignition and combustion. Indeed, modeling activities are today widely used in engine design, allowing a significant reduction in prototype development costs and providing a valuable support to the improvement of control strategies.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;Because the amount of low-temperature heat release (LTHR) strongly affects HCCI autoignition, it is important to determine the ability of kinetic models to accurately predict the LTHR over a range of operating conditions. In this work, the combustion behavior of PRF80 (a fuel showing LTHR at the conditions studied) in a 14:1 compression ratio engine operating in HCCI mode is experimentally and computationally analyzed. A new version of the Lawrence Livermore National Laboratory (LLNL) kinetic mechanism is used. This new mechanism contains substantial changes to the low-temperature chemistry that improve its ability to predict the behavior of PRF surrogates. With these improvements, the new mechanism achieves better agreement with rapid compression machine and shock tube data over a wide range of pressures and equivalence ratios. Model results are compared with HCCI engine experiments showing the effects of equivalence the ratio and engine speed on the phasing of both the low - and high-temperature heat release. Particular emphasis is placed on the ability of the model to predict the onset of LTHR at different engine conditions.&lt;/div&gt;
Data from Activating an Adaptive Immune Response with a Telomerase-Mediated Telomere Targeting Therapeutic in Hepatocellular Carcinoma (2023)

&lt;div&gt;Abstract&lt;p&gt;A select group of patients with hepatocellular carcinomas (HCC) benefit from surgical, radiologic, and systemic therapies that include a combination of anti-angiogenic and immune-checkpoint inhibitors. However, because HCC is generally asymptomatic in its early stages, this not only leads to late diagnosis, but also to therapy resistance. The nucleoside analogue 6-thio-dG (THIO) is a first-in-class telomerase-mediated telomere-targeting anticancer agent. In telomerase expressing cancer cells, THIO is converted into the corresponding 5′-triphosphate, which is efficiently incorporated into telomeres by telomerase, activating telomere damage responses and apoptotic pathways. Here, we show how THIO is effective in controlling tumor growth and, when combined with immune checkpoint inhibitors, is even more effective in a T-cell-dependent manner. We also show telomere stress induced by THIO increases both innate sensing and adaptive antitumor immunity in HCC. Importantly, the extracellular high-mobility group box 1 protein acts as a prototypical endogenous DAMP (Damage Associated Molecular Pattern) in eliciting adaptive immunity by THIO. These results provide a strong rationale for combining telomere-targeted therapy with immunotherapy.&lt;/p&gt;&lt;/div&gt;
BTC Image Coding Using Vector Quantization (1987)

This paper describes source encoding of the outputs of a block truncation coder (BTC), namely, the overhead statistical information and the truncated block. The statistical overhead and the truncated block exhibit properties which can be effectively used for their quantization as vectors. Vector quantization of these BTC outputs results into reduction of the bit rate of the coder. The bit rate reduces up to 1.5 bits/ pel if vector quantization is used on one of the outputs; i.e., either the overhead information or the truncated block. By vector quantizing both the BTC outputs the bit rate can he reduced up to 1.0 bits/pel without introducing many perceivable errors in the reconstructed output.
Unchanged expression of Epstein-Barr virus-determined nuclear antigen-1 in productive virus cycle. (1988)

The level of the Epstein-Barr virus (EBV)-determined nuclear antigen (EBNA-1) encoded by the Bam HI-K fragment of EBV DNA remained unchanged in P3HR-1 cells after induction of the productive cycle of virus replication by sodium-n-butyrate and 12-o-tetradecanoylphorbol-13-acetate (TPA). This was shown by the same capacity of cell-free extracts from untreated and treated P3HR-1 cells to absorb anti-EBNA-1 antibody from a known human serum.
Deciphering the essentiality and function of the anti‐σM factors in Bacillus subtilis (2019)

Bacteria use alternative sigma factors to adapt to different growth and stress conditions. The Bacillus subtilis extracytoplasmic function sigma factor SigM regulates genes for cell wall synthesis and is crucial for maintaining cell wall homeostasis under stress conditions. The activity of SigM is regulated by its anti-sigma factor, YhdL, and the accessory protein YhdK. Here, we show that dysregulation of SigM caused by the absence of either component of the anti-sigma factor complex leads to toxic levels of SigM and severe growth defects. High SigM activity results from a dysregulated positive feedback loop, and can be suppressed by overexpression of the housekeeping sigma, SigA. Using a sigM merodiploid strain, we selected for suppressor mutations that allow survival of yhdL depletion strain. The recovered suppressor mutations map to the beta and beta-prime subunits of RNA polymerase core enzyme and selectively reduce SigM activity, and in some cases increase the activity of other alternative sigma factors. This work highlights the ability of mutations in RNA polymerase that remodel the sigma-core interface to differentially affect sigma factor activity, and thereby alter the transcriptional landscape of the cell.
Reducing non-radiative voltage losses in organic solar cells using molecular encapsulation (2023)

Molecular encapsulation is a promising strategy to reduce non-radiative losses and enhance stability of organic solar cells, via reduced aggregation in the polymer phase. Encapsulated polymers demonstrated enhanced electroluminescence and better donor–acceptor intermixing.
Contemporary perspectives on heterotopic ossification (2022)

Heterotopic ossification (HO) is the formation of ectopic bone that is primarily genetically driven (fibrodysplasia ossificans progressiva [FOP]) or acquired in the setting of trauma (tHO). HO has undergone intense investigation, especially over the last 50 years, as awareness has increased around improving clinical technologies and incidence, such as with ongoing wartime conflicts. Current treatments for tHO and FOP remain prophylactic and include NSAIDs and glucocorticoids, respectively, whereas other proposed therapeutic modalities exhibit prohibitive risk profiles. Contemporary studies have elucidated mechanisms behind tHO and FOP and have described new distinct niches independent of inflammation that regulate ectopic bone formation. These investigations have propagated a paradigm shift in the approach to treatment and management of a historically difficult surgical problem, with ongoing clinical trials and promising new targets.
Addressing the permanent deformation behavior of hot mix asphalt by triaxial cyclic compression testing with cyclic confining pressure (2015)

Rutting or permanent deformation is one of the major distress modes of hot mix asphalt in the field. Triaxial cycle compression testing (TCCT) is a standardized and scientifically accepted test method to address this distress mode in the lab and to characterize the resistance to permanent deformation. In most labs and according to EN 12697-25, standard TCCTs are carried out with cyclic axial loading and a constant confining pressure. In road pavements on the other hand, dynamic traffic loading due to passing wheels leads to cyclic confining pressure. In order to bring the TCCT closer to reality, the radial reaction and its phase lag to axial loading in standard TCCTs are analyzed and an enhanced TCCT with cyclic confining pressure is introduced. The cyclic confining pressure takes into account the viscoelastic material response by the radial phase lag to axial phase loading. In a subsequent test program, TCCTs with different confining pressure amplitudes were carried out on two hot mix asphalts. Results from standard and enhanced TCCTs were analyzed, compared and discussed. It is shown that the resistance to permanent deformation increases significantly when the viscoelastic material response is taken into account in the TCCT by introducing cyclic confining pressure.