gebhart/patrepeval huggingface dataset:
Disease-Association Analysis of an Inflammation-Related Feedback Loop (2013)

The IL-6-triggered positive feedback loop for NFκB signaling (or the IL-6 amplifier/Inflammation amplifier) was originally discovered as a synergistic-activation signal that follows IL-17/IL-6 stimulation in nonimmune cells. Subsequent results from animal models have shown that the amplifier is activated by stimulation of NFκB and STAT3 and induces chemokines and inflammation via an NFκB loop. However, its role in human diseases is unclear. Here, we combined two genome-wide mouse screens with SNP-based disease association studies, revealing 1,700 genes related to the IL-6 amplifier, 202 of which showed 492 indications of association with ailments beyond autoimmune diseases. We followed up on ErbB1 from our list. Blocking ErbB1 signaling suppressed the IL-6 amplifier, whereas the expression of epiregulin, an ErbB1 ligand, was higher in patients with inflammatory diseases. These results indicate that the IL-6 amplifier is indeed associated with human diseases and disorders and that the identified genes may make for potential therapeutic targets.
Soreness and ulcers 5: biology, diagnosis and management of cancer regimen 1 (2017)

Click to launch & play an online audio visual presentation by Prof. Stephen T. Sonis on Soreness and ulcers 5: biology, diagnosis and management of cancer regimen 1, part of a collection of multimedia lectures.
Efficient single sideband microwave to optical conversion using an electro-optical whispering gallery mode resonator (2016)

Linking classical microwave electrical circuits to the optical telecommunication band is at the core of modern communication. Future quantum information networks will require coherent microwave-to-optical conversion to link electronic quantum processors and memories via low-loss optical telecommunication networks. Efficient conversion can be achieved with electro-optical modulators operating at the single microwave photon level. In the standard electro-optic modulation scheme this is impossible because both, up- and downconverted, sidebands are necessarily present. Here we demonstrate true single sideband up- or downconversion in a triply resonant whispering gallery mode resonator by explicitly addressing modes with asymmetric free spectral range. Compared to previous experiments, we show a three orders of magnitude improvement of the electro-optical conversion efficiency reaching 0.1% photon number conversion for a 10GHz microwave tone at 0.42mW of optical pump power. The presented scheme is fully compatible with existing superconducting 3D circuit quantum electrodynamics technology and can be used for non-classical state conversion and communication. Our conversion bandwidth is larger than 1MHz and not fundamentally limited.
Changes in cascading failure risk with generator dispatch method and system load level (2014)

Industry reliability rules increasingly require utilities to study and mitigate cascading failure risk in their system. Motivated by this, this paper describes how cascading failure risk, in terms of expected blackout size, varies with power system load level and pre-contingency dispatch. We used Monte Carlo sampling of random branch outages to generate contingencies, and a model of cascading failure to estimate blackout sizes. The risk associated with different blackout sizes was separately estimated in order to separate small, medium, and large blackout risk. Results from N − 1 secure models of the IEEE RTS case and a 2383 bus case indicate that blackout risk does not always increase with load level monotonically, particularly for large blackout risk. The results also show that risk is highly dependent on the method used for generator dispatch. Minimum cost methods of dispatch can result in larger long distance power transfers, which can increase cascading failure risk.
Anterior compartment syndrome of the leg, a clinical-anatomical perspective: A case report (1998)

Decompression of the fascial compartments of the leg is a fairly common procedure that is carried out therapeutically and prophylactically. It is submitted that the guidance offered by the average surgical texts are unclear and imprecise. A junior surgeon would be led to believe that all four compartments require decompression, whereas it is distinctly uncommon for compartments other than the anterior to suffer compression. Anatomic reasons are offered for this predilection. The incisions advised often extend the full length of the leg; not only is this unnecessary but considerable morbidity may result. A case report is presented which underlines the result of an ill placed incision and unfamiliarity with the detailed anatomy of the anterolateral leg muscles. An incision is suggested which is very unlikely to lead to failure to decompress and which should avoid complications.
Chemically Activated Carbon Synthesized from Rice Husk for Adsorption of Methylene Blue in Polluted Water (2023)

Rice husk (RH)-based activated carbons (ACs) were successfully manufactured and used as an adsorbent for the removal of methylene blue (MB) dye from polluted water. ACs were created by impregnating RH char with sodium hydroxide and then activating it for 1 h in a nitrogen environment at various activation temperatures. The characteristics of the obtained ACs were confirmed using Brunauer-Emmett-Teller analysis, scanning electron microscopy, X-ray diffraction analysis, and Fourier-transform infrared spectroscopy. The prepared ACs' pore volume and surface area increased with increasing temperature. The maximum specific surface area of the ACs sample was 729.4 m2/g at 900°C activation temperature. Adsorption was used to remove MB dye from polluted water using the obtained product. The effect of experimental parameters like adsorbent dosage, initial MB dye concentration, contact time, temperature, and pH of the MB dye solution was studied. The synthesized ACs were found to remove 80% of the MB dye under optimal conditions of pH (8), initial concentration (50 mg/L), and contact time (120 min). To represent the fitness of the adsorption data, the Langmuir and Freundlich isotherm models were used. The Langmuir model was found to be the best fit to equilibrium data, with R2 = 0.9972. Similarly, using pseudo first-order and pseudo second-order kinetic models, MB dye adsorption on ACs followed the pseudo-second order with an R2 value of 0.99719. The results show that synthesized RH-based ACs have a high potential for use as an effective adsorbent for removing dye from polluted water.
Induced Liquid Crystallinity in Switchable Side-Chain Discotic Molecules (2004)

Here, we present a strategy whereby a water-soluble tricycloquinazoline (TCQ) core is generated by hydrolysis of the corresponding nonionic hexaacetate, presenting itself as a potential (discotic) mesogen. The in situ generated core fragment was then used as a hexaanionic building block (or tecton) for assembly into ordered liquid-crystalline aggregates using the Ionic Self-Assembly (ISA) technique. The success of this “liquid-crystal-on-demand” strategy is demonstrated by a simple example.
Enhanced electrochromic switching speed and electrochemical stability of conducting polymer film on an ionic liquid functionalized ITO electrode (2015)

The EC material exhibits faster switching speed and better electrochemical stability when incorporated with [BMIM]BF<sub>4</sub> ionic liquid.
Orthogonally additive holomorphic maps between C*-algebras (2015)

Let $A,B$ be C*-algebras, $B_A(0;r)$ the open ball in $A$ centered at $0$ with radius $r&gt;0$, and $H:B_A(0;r)\to B$ an orthogonally additive holomorphic map. If $H$ is zero product preserving on positive elements in $B_A(0;r)$, we show, in the commutative case when $A=C_0(X)$ and $B=C_0(Y)$, that there exist weight functions $h_n$'s and a symbol map $φ: Y\to X$ such that $$ H(f)=\sum_{n\geq1} h_n (f\circφ)^n, \quad\forall f\in B_{C_0(X)}(0;r). $$ In the general case, we show that if $H$ is also conformal then there exist central multipliers $h_n$'s of $B$ and a surjective Jordan isomorphism $J: A\to B$ such that $$ H(a) = \sum_{n\geq1} h_n J(a)^n, \quad\forall a\in B_A(0;r). $$ If, in addition, $H$ is zero product preserving on the whole $B_A(0;r)$, then $J$ is an algebra isomorphism. %Similar conclusions hold for orthogonally additive $n$-homogeneous polynomials which are $n$-isometries.
Loss of the Mismatch Repair Protein MSH6 in Human Glioblastomas Is Associated with Tumor Progression during Temozolomide Treatment (2007)

Loss of MSH6 occurs in a subset of post-XRT + temozolomide glioblastoma recurrences and is associated with tumor progression during temozolomide treatment, mirroring the alkylator resistance conferred by MSH6 inactivation in vitro. MSH6 deficiency may therefore contribute to the emergence of recurrent glioblastomas during temozolomide treatment.
A Black-oil Three-phase Model With Capillary Effects (2012)

Abstract The black-oil (BO) model for compositional effect in three-phase compressible flow with capillary pressure is discussed. The compositional framework is used in modeling of a BO that allows extending a BO model to a compositional model and vice versa. A total compressibility condition is defined for saturated and unsaturated cases when the capillary effects are not ignored.
Solid waste disposal site suitability evaluation in Montana (2015)

Solid waste disposal site suitability studies are needed for understanding potential environmental hazards and for licensing.The Montana Solid Waste Management Bureau identified twenty-one operating sites needing evaluation for solid waste disposal suitability.The sites were evaluated by on-site reconnaissance of soil and hydrogeologic factors.The primary criteria evaluated were permeability of surficial materials, groundwater flow, connection of shallow groundwater with deeper aquifers, and proximity to surface water.In general, a suitable site should be located in materials of low permeability with a deep water table, have no connection of shallow groundwater with deeper aquifers, and should be far from surface water.Fourteen of the twenty-one sites evaluated were unsuitable.Inadequate site suitability assessments were made prior to locating many solid waste disposal sites in Montana.Suitable sites exist within a five mile radius of each of the unsuitable sites.A small amount of data coupled with soil and hydrogeologic planning would lead to better siting.
Mutational analysis of the N-linked glycosylation sites of the SU envelope protein of Moloney murine leukemia virus (1992)

The role of the N-linked glycosylation sites in the major envelope glycoprotein, SU (gp70), of Moloney murine leukemia virus has been examined. By using site-specific oligonucleotide-directed mutagenesis, each of the seven glycan addition sites has been individually eliminated. Mutations resulting in the loss of a single glycosylation site produced, intracellularly, stable precursor SU-TM proteins which were 4 to 5 kDa smaller than the wild-type virus SU-TM protein. Mutant delta 1,4,7, a trimutant lacking three N-linked glycan addition sites, resulted in a viable, infectious virus with a stable SU-TM protein approximately 12 to 15 kDa smaller than the wild-type SU-TM protein. Five of the seven single-site mutations resulted in viable virus as judged by the release of reverse transcriptase in transient-expression assays and XC syncytium assays. Mutations at two of the sites resulted in a detectable phenotype. Virus mutated at position 2 was temperature sensitive in Rat2 cells; viable virus was produced at 32 degrees C but not at 37 degrees C. Virus mutated at position 3 was noninfectious and yielded virions lacking detectable mature SU protein. The mutation results in the block of transport of the protein to the cell surface and assembly into virion particles.
Performance of Two Resin-Containing Blood Culture Media in Detection of Bloodstream Infections and in Direct Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry (MALDI-TOF MS) Broth Assays for Isolate Identification: Clinical Comparison of the BacT/Alert Plus and Bactec Plus Systems (2014)

We compared the clinical performances of the BacT/Alert Plus (bioMérieux) and Bactec Plus (Becton Dickinson) aerobic and anaerobic blood culture (BC) media with adsorbent polymeric beads. Patients ≥ 16 years old with suspected bloodstream infections (BSIs) were enrolled in intensive care units and infectious disease wards. A single 40-ml blood sample was collected from each and used to inoculate (10 ml/bottle) one set of BacT/Alert Plus cultures and one set of Bactec Plus cultures, each set consisting of one aerobic and one anaerobic bottle. Cultures were incubated ≤ 5 days in the BacT/Alert 3D and Bactec FX instruments, respectively. A total of 128 unique BSI episodes were identified based on the recovery of clinically significant growth in 212 aerobic cultures (106 BacT/Alert and 106 Bactec) and 151 anaerobic cultures (82 BacT/Alert and 69 Bactec). The BacT/Alert aerobic medium had higher recovery rates for Gram-positive cocci (P = 0.024), whereas the Bactec aerobic medium was superior for recovery of Gram-negative bacilli (P = 0.006). BacT/Alert anaerobic medium recovery rates exceeded those of the Bactec anaerobic medium for total organisms (P = 0.003), Gram-positive cocci (P = 0.013), and Escherichia coli (P = 0.030). In terms of capacity for diagnosing the 128 septic episodes, the BacT/Alert and Bactec sets were comparable, although the former sets diagnosed more BSIs caused by Gram-positive cocci (P = 0.008). They also allowed earlier identification of coagulase-negative staphylococcal growth (mean, 2.8 h; P = 0.003) and growth in samples from patients not on antimicrobial therapy that yielded positive results (mean, 1.3 h; P < 0.001). Similarly high percentages of microorganisms in BacT/Alert and Bactec cultures (93.8% and 93.3%, respectively) were identified by direct matrix-assisted laser desorption ionization-time of flight mass spectrometry assay of BC broths. The BacT/Alert Plus media line appears to be a reliable, timesaving tool for routine detection of BSIs in the population we studied, although further studies are needed to evaluate their performance in other settings.
Obesity and Appetite Control (2012)

Obesity is one of the major challenges to human health worldwide; however, there are currently no effective pharmacological interventions for obesity. Recent studies have improved our understanding of energy homeostasis by identifying sophisticated neurohumoral networks which convey signals between the brain and gut in order to control food intake. The hypothalamus is a key region which possesses reciprocal connections between the higher cortical centres such as reward-related limbic pathways, and the brainstem. Furthermore, the hypothalamus integrates a number of peripheral signals which modulate food intake and energy expenditure. Gut hormones, such as peptide YY, pancreatic polypeptide, glucagon-like peptide-1, oxyntomodulin, and ghrelin, are modulated by acute food ingestion. In contrast, adiposity signals such as leptin and insulin are implicated in both short- and long-term energy homeostasis. In this paper, we focus on the role of gut hormones and their related neuronal networks (the gut-brain axis) in appetite control, and their potentials as novel therapies for obesity.
Wind turbine control strategy for shaft stress reduction (2013)

The issue of fatigue loading on wind turbine drive trains due to the fluctuating nature of wind is a major cause of premature gearbox failures. A new control scheme is proposed and investigated which aims to maintain speed control of the wind turbine, as well as being able to compensate for torque pulsations as a result of wind speed variations. These torque pulsations are the main cause of shaft overstressing and result in the premature failure of gearboxes, rotors and drive trains. The control strategy implemented makes use of well-known Proportional (P) and Proportional Derivative (PD) controllers, and therefore does not need sophisticated models of the wind turbine system requiring knowledge of parameters specific to the machine. The controller implemented consists of two control loops, the one being a speed control and the other a torque controller. The controller is implemented on a 2kW three-phase permanent magnet wind turbine. System simulations showed that the control strategy was able to operate successfully, however, in practice it was found that the speed control loop operated but the torque control was unsuccessful. This was due to high levels of noise as a result of the differential action on the torque feedback loop.
Ultrahigh-Repetition-Rate Half-Cycle Pulse Synthesizer Operating at 125 THz (2019)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text A. Tomura, C. Ohae, K. Minoshima, and M. Katsuragawa, "Ultrahigh-Repetition-Rate Half-Cycle Pulse Synthesizer Operating at 125 THz," in Frontiers in Optics + Laser Science APS/DLS, OSA Technical Digest (Optica Publishing Group, 2019), paper JTu4A.121. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Microbioreactor with Photodiode Detection for Monitoring Intracellular GFPUV Expression in E. coli (2014)

A prototype membrane aerated polydimethylsiloxane (PDMS) microbioreactor integrated with a photodiode detector was developed for monitoring intracellular green fluorescent protein ultraviolet (GFPUV) expression in Escherichia coli. The developed system is compact, simple and inexpensive and ideal for economical on chip detection of fluorophores in aqueous solution and intracellular GFPUV expression. The detection limit for cell free GFPUV was found to be 4.8 x 10-8 M. Intracellular GFPUV expression in E. coli cells was monitored for 12 h and the lowest detectable signal was recorded from a cell concentration of 2.7 x 107cells/mL with signal to noise ratio (SNR) value of 3. The performance of the photodiode detector was benchmarked with a CCD spectrophotometer and results showed favorable comparison. A miniaturized microbioreactor for monitoring intracellular dynamics in real time is demonstrated. - See more at: http://eurekaselect.com/126376#sthash.QCUJLlFh.dpuf
Abstract 4378: Novel CARP-1- H2AX interaction regulates apoptosis in breast cancer cells (2018)

Abstract CCAR1/CARP-1 is a peri-nuclear phosphoprotein that regulates apoptosis signaling by breast cancer therapeutic Doxorubicin and a novel class of CARP-1 Functional Mimetic (CFM) compounds. Prior reports have established that Doxorubicin exposure causes DNA damage in cells. Phosphorylation of histone 2AX (often referred as γH2AX) protein is involved in regulating DNA damage repair and apoptosis signaling. Although, currently it is unclear whether CFMs also induce DNA damage, we found that Doxorubicin or CFM-4.16 treatments caused elevated CARP-1 and γH2AX in HBC cells. In fact, a robust nuclear or peri-nuclear co-localization of CARP-1 and γH2AX occurred in HBC cells undergoing apoptosis. Knock-down of CARP-1 abolished increase of CARP-1 and γH2AX, their co-localization, and apoptosis in CFM-4.16 or Doxorubicin-treated HBC cells. We found that CARP-1 directly binds with H2AX, and the H2AX-interacting epitope is located within CARP-1 amino acids 600 to 652. We generated HBC cells that have stable expression of myc-tagged, wild-type CARP-1 (1-1150) or CARP-1 (1-1150; Δ600-652) mutant. Further analyses revealed that CARP-1 (1-1150), but not CARP-1 (1-1150; Δ600-652) mutant, interacted with H2AX. Moreover, HBC cells expressing CARP-1 (1-1150; Δ600-652) mutant were resistant to apoptosis by Doxorubicin or CFM-4.16, and had diminished levels of γH2AX, when compared with their counterparts expressing wild-type CARP-1. We have earlier reported involvement of the Stress-Activated Protein Kinases (SAPKs) such as p38 and JNKs in apoptosis by Doxorubicin or CFMs. Since the PI3K family of serine-threonine kinases ATM/ATR, as well as JNK SAPKs, phosphorylate serine-139 of H2AX following DNA damage, our current studies are investigating whether H2AX binding with CARP-1 serves to facilitate phosphorylation of CARP-1 and H2AX proteins for transduction of apoptosis signaling. Citation Format: Sreeja C. Sekhar, Vino T. Cheriyan, Arun K. Rishi. Novel CARP-1- H2AX interaction regulates apoptosis in breast cancer cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 4378.
Stillbirth in obstetric practice: report of survey findings (2003)

A comprehensive educational effort to include current knowledge regarding causes and management, standardized diagnostic procedures, death registration and case review is recommended to improve obstetric care of those with a stillbirth.
Algebraic/transcendental disturbance growth behind a row of roughness elements (2011)

This paper is a continuation of the work begun in Goldstein et al . ( J. Fluid Mech. , vol. 644, 2010, p. 123), who constructed an asymptotic high-Reynolds-number solution for the flow over a spanwise periodic array of relatively small roughness elements with (spanwise) separation and plan form dimensions of the order of the local boundary-layer thickness. While that paper concentrated on the linear problem, here the focus is on the case where the flow is nonlinear in the immediate vicinity of the roughness with emphasis on the intermediate wake region corresponding to streamwise distances that are large in comparison with the roughness dimension, but small in comparison with the distance between the roughness array and the leading edge. An analytical O ( h 2 ) asymptotic solution is obtained for the limiting case of a small roughness height parameter h . These weakly nonlinear results show that the spanwise variable component of the wall-pressure perturbation decays as x −5/3 ln x when x → ∞ (where x denotes the streamwise distance scaled on the roughness dimension), but the corresponding component of the streamwise velocity perturbation (i.e. the wake velocity) exhibits an O ( x 1/3 ln x ) algebraic/transcendental growth in the main boundary layer. Numerical solutions for h = O (1) demonstrate that the wake velocity perturbation for the fully nonlinear case grows in the same manner as the weakly nonlinear prediction – which is considerably different from the strictly linear result obtained in Goldstein et al . (2010).
Secure content management in authorised domains (2002)

Authorised Domains (AD) are introduced by DVB as a means to enable controlled electronic distribution of digital content.The main aim of an AD is to respect both the content provider's and consumer's interest, in the sense that the consumer is free to access and distribute content within the entire AD, while at the same time the rights of the content owners and service providers are covered by imposing strict import and export rules to prevent unlimited digital copying the content across domains.In this paper we present the requirements, an information model, and architecture for a specific AD realisation.
Conformance test experiments for distributed real-time systems (2002)

This paper introduces a new technique for testing that a distributed real-time system satisfies a formal timed automata specification. It outlines how to write test specifications in the language of Uppaal timed automata, how to translate those specifications into program code for executing the tests, and describes the results of test experiments on a distributed real-time system with limited hardware and software resources.