gebhart/patrepeval huggingface dataset:
Comb-laser driven WDM for short reach silicon photonic based optical interconnection (2012)

We describe an InAs/GaAs quantum dot laser used in conjunction with an SOI ring resonator modulation scheme to provide mutli-wavelength transmission for optical interconnects. The current proposed co-packaging solution may be extended using bonding technology.
APC/C Dysfunction Limits Excessive Cancer Chromosomal Instability (2017)

We report a mechanism whereby cancers balance the evolutionary advantages associated with CIN against the fitness costs caused by excessive genome instability, providing insight into the consequence of CDC27 APC/C subunit driver mutations in cancer. Lengthening of mitosis through APC/C modulation may be a common mechanism of resistance to cancer therapeutics that increase chromosome segregation errors. Cancer Discov; 7(2); 218-33. ©2017 AACR.See related commentary by Burkard and Weaver, p. 134This article is highlighted in the In This Issue feature, p. 115.
Tetrathiafulvalene-Based Architectures: From Guests Recognition to Self-Assembly (2011)

Abstract The tetrathiafulvalene (TTF) unit has been successfully used for an incredibly broad range of applications. Beyond the well-established conducting properties of the corresponding cation-radical salts, this unit has appeared as a key redox-active component for various applications supported by its remarkable redox properties: a high π-donating ability and occurrence of three stable redox states. This article reviews the main contribution of the group of Angers to this field, highlighting results obtained in terms of redox-sensing as well as efforts carried out to reach new self-assembled TTF-based architectures.
Topical report on a preconceptual design for the Spallation-Induced Lithium Conversion (SILC) target for the accelerator production of tritium (APT) (1993)

The preconceptual design of the APT Li-Al target system, also referred to as the Spallation-Induced Lithium Conversion (SILC), target system, is summarized in this report. The system has been designed to produce a ``3/8 Goal`` quantity of tritium using the 200-mA, 1.0 GeV proton beam emerging from the LANL-designed LINAC. The SILC target system consists of a beam expander, a heavy-water-cooled lead spallation neutron source assembly surrounded by light-water-cooled Li-Al blankets, a target window, heat removal systems, and related safety systems. The preconceptual design of each of these major components is described. Descriptions are also provided for the target fabrication, tritium extraction, and waste-steam processes. Performance characteristics are presented and discussed.
Analysis of risk to biomedical products developed from animal sources (with special emphasis on the spongiform encephalopathy agents, scrapie and BSE). (1996)

Factors that must be considered in estimations of risk from exposure to adventitious contaminants of animal derived biologicals include: (i) the use of the product; (ii) the routes of administration and exposure to potential pathogens; (iii) the source of animal(s) and their history and maintenance; (iv) the tissue(s) used in the product and their likelihood of harbouring or being contaminated by an agent; (v) the methods by which the animal is slaughtered and the tissue(s) collected; (vi) the production process including steps that remove an agent either by inactivation or physical separation; (vii) the disposal of an agent that is sequestered but not inactivated; (viii) flow control, barriers, and between-batch cleaning; (ix) batch size; and (x) validations and quality assurance monitoring. The transmissible spongiform encephalopathy (TSE) agents, scrapie and bovine spongiform encephalopathy (BSE) are among the most difficult to detect and remove from animal tissues. As such they constitute an especially stringent challenge for viral clearance.
Beckmann Rearrangement of Oximes Catalyzed with Tetrabutylammonium Perrhenate and Trifluoromethanesulfonic Acid (1995)

Abstract The Beckmann rearrangement of oximes is catalyzed by a combined use of tetrabutylammonium perrhenate (Bu4NReO4) and trifluoromethanesulfonic acid in nitromethane under azeotropic conditions, giving amides in high yield. By employing this catalytic system, amides can be prepared directly from ketones and hydroxylamine hydrochloride.
Sister chromatid exchanges induced by perturbed replication are formed independently of homologous recombination factors (2021)

Summary Sister chromatid exchanges (SCEs) are products of joint DNA molecule resolution, and are considered to form through homologous recombination (HR). Indeed, upon generation of irradiation-induced DNA breaks, SCE induction was compromised in cells deficient for canonical HR factors BRCA1, BRCA2 and RAD51. Contrarily, replication-blocking agents, including PARP inhibitors, induced SCEs independently of BRCA1, BRCA2 and RAD51. PARP inhibitor-induced SCEs were enriched at common fragile sites (CFSs), and were accompanied by post-replicative single-stranded DNA (ssDNA) gaps. Moreover, PARP inhibitor-induced replication lesions were transmitted into mitosis, suggesting that SCEs originate from mitotic processing of under-replicated DNA. We found that DNA polymerase theta (POLQ) was recruited to mitotic DNA lesions, and loss of POLQ resulted in reduced SCE numbers and severe chromosome fragmentation upon PARP inhibition in HR-deficient cells. Combined, our data show that PARP inhibition generates under-replicated DNA, which is transferred into mitosis and processed into SCEs, independently of canonical HR factors.
Control of Avian Coccidiosis: Future and Present Natural Alternatives (2015)

Numerous efforts to date have been implemented in the control of avian coccidiosis caused by the Eimeria parasite. Since the appearance of anticoccidial chemical compounds, the search for new alternatives continues. Today, no product is available to cope with the disease; however, the number of products commercially available is constantly increasing. In this review, we focus on natural products and their anticoccidial activity. This group comprises fatty acids, antioxidants, fungal and herbal extracts, and immune response modulators with proven anticoccidial activity, many of which exist as dietary supplements. Additionally, we offer an overview of the poultry industry and the economic cost of coccidiosis as well as the classical strategies used to control the disease.
Heparin oligosaccharides bind L- and P-selectin and inhibit acute inflammation (1993)

Initial attachment of leukocytes to the vessel wall at sites of inflammation is supported by a family of carbohydrate-binding adhesion molecules called the selectins. Selectin ligands include sialyl-Lewis x (sLex, Neu5Ac alpha 2–3Gal beta 1–4[Fuc alpha 1–3]GlcNAc--) and related structures. We report here that defined heparin oligosaccharides interact with the selectins. Heparin chains containing four or more monosaccharide residues inhibited the function of L- and P-selectin, but not E-selectin, in vitro. In a competition enzyme-linked immunosorbent assay measuring inhibition of solution-phase selectin-Ig fusion proteins (selectin-Ig) binding to immobilized bovine serum albumin-sLex neoglycoprotein, a heparin-derived tetrasaccharide mixture inhibited 50% of L- and P-selectin-Ig binding (IC50) at 200 +/- 40 mumol/L and 850 +/- 110 mumol/L, respectively. A single hexasulfated tetrasaccharide (delta UA2S alpha 1–4GlcNS6S alpha 1–4IdoA2S alpha 1- 4GlcNS6S) was particularly active against L- and P-selectin-Ig (IC50 = 46 +/- 5 mumol/L and 341 +/- 24 mumol/L). By comparison, the tetrasaccharide sLex was not inhibitory at concentrations up to 1 mmol/L. In cell adhesion assays, heparin tetrasaccharides reduced binding of neutrophils to COS cells expressing P-selectin but not to COS cells expressing E-selectin. They also blocked colon cancer cell adhesion to L- and P-selectin but not E-selectin. In a model of acute inflammation, intravenously administered heparin tetrasaccharides diminished influx of neutrophils into the peritoneal cavities of thioglycollate-treated mice. We conclude that heparin oligosaccharides, including non-anticoagulant tetrasaccharides, are effective L- and P- selectin inhibitors in vitro and have anti-inflammatory activity in vivo.
Improved Tone Reservation Method Based on Deep Learning for PAPR Reduction in OFDM System (2019)

This paper utilizes deep learning (DL) in tone reservation (TR) to reduce the peak-to-average power ratio (PAPR) of orthogonal frequency division multiplexing (OFDM). We propose TR based on DL (DL-TR) algorithm by considering each iteration of the classical TR algorithm as a layer of a deep neural network (DNN), and then train the network offline to obtain the clipping ratio of each layer which can minimize the loss function that is the sum of PAPR and the increased transmit power. Compared with the conventional TR method, the simulation results show that the proposed DL-TR provides a better PAPR reduction and bit-error-rate (BER) performance.
Conceptualising the policy practice and behavioural research relationship (2008)

The model has implications for guiding behavioural research and policy practice priorities to promote public health outcomes. In particular, we propose that policy practice and behavioural research activities can be strengthened by applying to each other the theories from the scientific disciplines informing these respective activities. Behavioural science theories can be applied to help understand policy-making and assist with disseminating research into policy and practice. In turn, policy science theories can be applied to support the 'institutionalisation' of commitments to ongoing behavioural research.
Oxygen Transport Properties of Organic Electrolytes and Performance of Lithium/Oxygen Battery (2003)

The oxygen transport properties of several organic electrolytes were characterized through measurements of oxygen solubility and electrolyte viscosity. Oxygen diffusion coefficients were calculated from electrolyte viscosities using the Stokes-Einstein relation. Oxygen solubility, electrolyte viscosity, and oxygen partial pressure were all directly correlated to discharge capacity and rate capability. Substantial improvement in cell performance was achieved through electrolyte optimization and increased oxygen partial pressure. The concentration of oxygen in the electrode under discharge was calculated using a semi-infinite medium model with simultaneous diffusion and reaction. The model was used to explain the dependence of cell performance on oxygen transport in organic electrolyte. © 2003 The Electrochemical Society. All rights reserved.
Supplementary Figure S3 from Deregulation of the PP2A Inhibitor SET Shows Promising Therapeutic Implications and Determines Poor Clinical Outcome in Patients with Metastatic Colorectal Cancer (2023)

&lt;p&gt;Supplementary Figure S3. Effect of SET silencing in the sensitivity of CRC cells to 5-FU alone or combined with oxaliplatin.&lt;/p&gt;
Aggressor alignment for worst-case coupling noise (2000)

Article Free Access Share on Aggressor alignment for worst-case coupling noise Authors: Lauren Hui Chen Electrical and Computer Engineering Department, University of California, Santa Barbara, Santa Barbara, CA Electrical and Computer Engineering Department, University of California, Santa Barbara, Santa Barbara, CAView Profile , Malgorzata Marek-Sadowska Electrical and Computer Engineering Department, University of California, Santa Barbara, Santa Barbara, CA Electrical and Computer Engineering Department, University of California, Santa Barbara, Santa Barbara, CAView Profile Authors Info & Claims ISPD '00: Proceedings of the 2000 international symposium on Physical designMay 2000 Pages 48–54https://doi.org/10.1145/332357.332373Published:01 May 2000Publication History 12citation137DownloadsMetricsTotal Citations12Total Downloads137Last 12 Months14Last 6 weeks9 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
CompressGraph: Efficient Parallel Graph Analytics with Rule-Based Compression (2023)

Modern graphs exert colossal time and space pressure on graph analytics applications. In 2022, Facebook social graph reaches 2.91 billion users with trillions of edges. Many compression algorithms have been developed to support direct processing on compressed graphs to address this challenge. However, previous graph compression algorithms do not focus on leveraging redundancy in repeated neighbor sequences, so they do not save the amount of computation for graph analytics. We develop CompressGraph, an efficient rule-based graph analytics engine that leverages data redundancy in graphs to achieve both performance boost and space reduction for common graph applications. CompressGraph has three advantages over previous works. First, the rule-based abstraction of CompressGraph supports the reuse of intermediate results during graph traversal, thus saving time. Second, CompressGraph has intense expressiveness to support a wide range of graph applications. Third, CompressGraph scales well under high parallelism because the context-free rules have few dependencies. Experiments show that CompressGraph provides significant performance and space benefits on both CPUs and GPUs. On evaluating six typical graph applications, CompressGraph can achieve 1.97× speedup on the CPU, while 3.95× speedup on the GPU, compared to the state-of-the-art CPU and GPU methods, respectively. Moreover, CompressGraph can save an average of 71.27% memory savings on CPU and 70.36 on GPU.
Fabrication of Nb<SUB>3</SUB>Sn Superconducting Wire by the Clad-Chip Extrusion Method (1992)

The Clad-Chip Extrusion (CCE) method is applied to a fabrication process of Nb3Sn superconducting wires. This method is characterized by extruding the chipped Nb-Sn clad sheets with the intended chemical composition. Ti-foil cladding to the Nb-Sn composite sheet is also studied as a method of titanium addition. An extruded Nb-Sn composite bar shows good workability in wire drawing up to a relatively high reduction ratio, R of 106, where R is the cross-section ratio of an initial billet to a final wire.The CCE-processed Nb3Sn wire heat-treated under the optimum condition shows the critical transition temperature, Tc of 17.8 K and the critical current density, Jc of 1.18×108 A·m−2 in the applied magnetic field of 20 T at 4.2 K. The upper critical field, B∗c2 (4.2 K) is estimated as 23.4 T using the Kramer plot.
Quantitative Determination of 10 Phenylpropanoid and Lignan Compounds inLancea tibeticaby High-Performance Liquid Chromatography with UV Detection (2011)

An HPLC method was developed for simultaneous determination of one phenylpropanoid glycoside, verbascoside (1), and nine lignans, including lantibeside (2), phillyrin (3), lantibeside B (4), lantibeside C (5), tibeticoside A (6), styraxjaponoside C (7), sylvatesmin (8), (+)-piperitol (9), and horsfieldin (10), from the Tibetan medicinal plant Lancea tibetica Hook. F. et Thoms. The analysis was performed within 45 min. The extraction method was optimized with different solvent systems. The HPLC method was validated for linearity, repeatability, accuracy, limits of detection, and limits of quantification. The limits of detection and limits of quantification of 10 analytes were found to be less than 0.1 and 0.5 µg/mL, respectively. The RSD for intra- and inter-day analyses was less than 4.2 %, and the recovery efficiency was 90-105 %. The method was used to analyze different populations of L. tibetica collected in China. HPLC profiles showed that the concentrations of analytes were different in samples collected from different areas of China. Verbascoside was the dominant component in three out of five plant samples; compounds 2, 3, 6, and 8 accounted for over 62 % yields in total lignan contents. The method is useful for identification, quality assurance, and quality control of L. tibetica and its related products.
Performance of clinical guidelines compared with molecular tumour screening methods in identifying possible Lynch syndrome among colorectal cancer patients: a Norwegian population-based study (2010)

Assuming a fairly high accuracy of molecular testing, the performance of the RBG in identifying patients with possible LS was poor, and the AM II criteria falsely identified a large proportion as having possible LS. This favours the use of molecular testing in the diagnosis of possible LS.
Sources of spontaneous narrow-band UV and VUV radiation (2007)

Pre-production models of excilamps developed in the laboratory of optical radiation are described; main characteristics of radiators and their power supplies, portable UV-excilamps of the barrier or capacitive discharges, and also powerful VUV-excilamps of the barrier discharge which can be used for cleaning or modifying material surfaces are presented.
The crystal structure of nsp10-nsp16 heterodimer from SARS-CoV-2 in complex with S-adenosylmethionine (2020)

SARS-CoV-2 is a member of the coronaviridae family and is the etiological agent of the respiratory Coronavirus Disease 2019. The virus has spread rapidly around the world resulting in over two million cases and nearly 150,000 deaths as of April 17, 2020. Since no treatments or vaccines are available to treat COVID-19 and SARS-CoV-2, respiratory complications derived from the infections have overwhelmed healthcare systems around the world. This virus is related to SARS-CoV-1, the virus that caused the 2002-2004 outbreak of Severe Acute Respiratory Syndrome. In January 2020, the Center for Structural Genomics of Infectious Diseases implemented a structural genomics pipeline to solve the structures of proteins essential for coronavirus replication-transcription. Here we show the first structure of the SARS-CoV-2 nsp10-nsp16 2'-O-methyltransferase complex with S-adenosylmethionine at a resolution of 1.80 Å. This heterodimer complex is essential for capping viral mRNA transcripts for efficient translation and to evade immune surveillance.
DStretch® et l'amélioration des images numériques: applications à l'archéologie des images rupestres (2013)

Among all the tools currently available for rock art studies, DStretch®, plug-in for ImageJ© designed specifically for the enhancement of digital images of pictographs, seems to be one of the most efficient to decipher fainted figures while being fast, easy to use and cheap. The examples presented here show that DStretch is currently one of the best way to achieve what should be now the scientific standards for image enhancement of rock paintings and, in some cases, engravings.
Identification of Tuberculosis Susceptibility Genes with Human Macrophage Gene Expression Profiles (2008)

Although host genetics influences susceptibility to tuberculosis (TB), few genes determining disease outcome have been identified. We hypothesized that macrophages from individuals with different clinical manifestations of Mycobacterium tuberculosis (Mtb) infection would have distinct gene expression profiles and that polymorphisms in these genes may also be associated with susceptibility to TB. We measured gene expression levels of >38,500 genes from ex vivo Mtb-stimulated macrophages in 12 subjects with 3 clinical phenotypes: latent, pulmonary, and meningeal TB (n = 4 per group). After identifying differentially expressed genes, we confirmed these results in 34 additional subjects by real-time PCR. We also used a case-control study design to examine whether polymorphisms in differentially regulated genes were associated with susceptibility to these different clinical forms of TB. We compared gene expression profiles in Mtb-stimulated and unstimulated macrophages and identified 1,608 and 199 genes that were differentially expressed by >2- and >5-fold, respectively. In an independent sample set of 34 individuals and a subset of highly regulated genes, 90% of the microarray results were confirmed by RT-PCR, including expression levels of CCL1, which distinguished the 3 clinical groups. Furthermore, 6 single nucleotide polymorphisms (SNPs) in CCL1 were found to be associated with TB in a case-control genetic association study with 273 TB cases and 188 controls. To our knowledge, this is the first identification of CCL1 as a gene involved in host susceptibility to TB and the first study to combine microarray and DNA polymorphism studies to identify genes associated with TB susceptibility. These results suggest that genome-wide studies can provide an unbiased method to identify critical macrophage response genes that are associated with different clinical outcomes and that variation in innate immune response genes regulate susceptibility to TB.
Spatial tuning loss of pattern reversal visual evoked response in optic nerve disease (1996)

We compared the pattern reversal visual evoked response (PVER) amplitude-check size functions from 25 eyes (25 normal subjects; visual acuities > or = 20/20) with those from 32 eyes (22 patients; visual acuities 20/15 to 20/50; mean, 20/25.5) with mild optic nerve disease to determine if spatial tuning loss of the PVER occurs in the presence of optic nerve dysfunction. The steady-state PVER was recorded with five check sizes (range, 160 to 10 minutes of arc). To analyze the PVER amplitude-check size function, we calculated the difference between the maximum and minimum PVER amplitudes and then calculated the area of spatial tuning (the area under the function). Values were significantly smaller in patients than in normal subjects (1.81 +/- 1.27 microV versus 5.73 +/- 3.27 microV; F = 41.24, p = 0.0001; 3.87 +/- 2.70 area units versus 12.57 +/- 7.60 area units; F = 38.62, p = 0.0001). There was no shift in the distribution of peak check sizes. Results suggest that a spatial tuning loss occurs in optic nerve disease. The shape of the function, including the area of spatial tuning, appears to be a sensitive indicator of early or mild optic nerve dysfunction.
Thin-film deposition by a new laser ablation and plasma hybrid technique (1989)

We have developed a new laser ablation and plasma hybrid technique for depositing thin diamond-like carbon (DLC) films on Si〈100〉 substrates at room temperature and at 110 °C with improved optical and mechanical properties. The technique involves coupling of laser energy (λ=0.308 μm, pulse duration=40 ns, and power 125 MW/cm2) to a graphite target and superimposing capacitively stored energy (2–3 J at 3 kV) to the laser ablated spot. The laser- and plasma-deposited diamond-like carbon films were analyzed by spectroscopic ellipsometry and microhardness measurements. These films showed considerable improvements in both uniformity and homogeneity. Optical properties and hardness of the films deposited by this technique closely match the DLC films. We discuss possible causes of improvements in the above properties of these films.