gebhart/patrepeval huggingface dataset:
Lens opacity after neodymium:YAG laser iridectomy for phakic intraocular lens implantation (1999)

We describe a previously unreported complication of a posterior chamber intraocular lens (IOL) implanted in a phakic eye. The left eye of a 25-year-old patient with high myopia was treated prophylactically with neodymium: YAG (Nd: YAG) laser iridotomy prior to phakic IOL implantation. Slitlamp examination of the left eye disclosed an opacity of the anterior capsule of the crystalline lens under the iridotomy site. This case demonstrates a complication associated with Nd:YAG iridotomy prior to implantation of a phakic IOL.
Copper(II) Complexes of 10,20-Diaryl-5,15-diazaporphyrin: Alternative Synthesis, Excited State Dynamics, and Substituent Effect on the 1O2-Generation Efficiency (2022)

Abstract The synthesis, excited state dynamics, and substituent effect on the 1O2-generation efficiency of several copper(II) complexes of 5,15-diazaporphyrin (CuDAPs) bearing peripheral substituents are reported. 10,20-Diaryl-CuDAPs were prepared via a new method consisting of metal-templated cyclization and N-dealkylation as key steps. The effect of the β-substituents on the optical and redox properties of CuDAP was stronger than that of the meso-aryl groups, which can be explained by considering the characteristics of the HOMO and LUMO of the DAP ring. The excited state dynamics and 1O2-generation efficiency of CuDAPs were studied using time-resolved spectroscopic techniques; the electronic effect of the meso-aryl groups on the triplet lifetime and 1O2-generation quantum yield was relatively weak, whereas that of the β-(1-pyrazolyl) groups was appreciable. The analysis of the temperature dependence of phosphorescence spectra of 10,20-bis(2,4,6-trimethylphenyl)-CuDAP allowed the energy gap between the excited trip-quartet and trip-doublet states to be determined. The relatively long triplet lifetimes of CuDAPs show their potential for future application as photosensitizers.
Data from Genomic Estimates of Aneuploid Content in Glioblastoma Multiforme and Improved Classification (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Accurate classification of glioblastoma multiforme (GBM) is crucial for understanding its biologic diversity and informing diagnosis and treatment. The Cancer Genome Atlas (TCGA) project identified four GBM classes using gene expression data and separately identified three classes using methylation data. We sought to integrate multiple data types in GBM classification, understand biologic features of the newly defined subtypes, and reconcile with prior studies.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; We used allele-specific copy number data to estimate the aneuploid content of each tumor and incorporated this measure of intratumor heterogeneity in class discovery. We estimated the potential cell of origin of individual subtypes and the euploid and aneuploid fractions using reference datasets of known neuronal cell types.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; There exists an unexpected correlation between aneuploid content and the observed among-tumor diversity of expression patterns. Joint use of DNA and mRNA data in &lt;i&gt;ab initio&lt;/i&gt; class discovery revealed a distinct group that resembles the Proneural subtype described in a separate study and the glioma-CpG island methylator phenotype (G-CIMP+) class based on methylation data. Three additional subtypes, Classical, Proliferative, and Mesenchymal, were also identified and revised the assignment for many samples. The revision showed stronger differences in patient outcome and clearer cell type–specific signatures. Mesenchymal GBMs had higher euploid content, potentially contributed by microglia/macrophage infiltration.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusion:&lt;/b&gt; We clarified the confusion about the “Proneural” subtype that was defined differently in different prior studies. The ability to infer within-tumor heterogeneity improved class discovery, leading to new subtypes that are closer to the fundamental biology of GBM. &lt;i&gt;Clin Cancer Res; 18(20); 5595–605. ©2012 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Effect of the modified SPI on the technology and quality of the milk production (2009)

In this paper,two kinds of mixed milk were made from milk powder and modified SPI.The effects of the deployment method,homogeneous conditions and sterilization condition on the color,taste and stability of the product were studied in this paper.The modified SPI that we used was low-oxidative,which is good at gelling and emulsifying.A lab color space was used to characterize the color's changes of the product.And the product's stability was characterized by the sedimentation rate and stability factor.The results showed that,during preparation,the homogeneous conditions and sterilization condition had a great impact on the quality of the product.Besides those conditions,when we made acid milk,we should also take the pH and sugar content of the product into consideration.The homogeneous condition of 65℃、25MPa will be fine for both the neutral and the acid kinds of products.And we choose 100℃、20min and 65℃、30min as sterilization condition for the neutral milk and the acid milk,respectively.
Towards a Technique for Extracting Microservices from Monolithic Enterprise Systems (2016)

The idea behind microservices architecture is to develop a single large, complex application as a suite of small, cohesive, independent services. On the other way, monolithic systems get larger over the time, deviating from the intended architecture, and becoming risky and expensive to evolve. This paper describes a technique to identify and define microservices on monolithic enterprise systems. As the major contribution, our evaluation shows that our approach was able to identify relevant candidates to become microservices on a 750 KLOC banking system.
c-Jun NH2-Terminal Kinase 2 Is Required for Ras Transformation Independently of Activator Protein 1 (2007)

Active Ras oncogene is expressed in approximately 30% of human cancers. Yet, very little is known about the molecular mechanisms responsible for its transforming potential. Here, we show that H-Ras-mediated transformation requires isoform 2 of the c-Jun-NH(2)-terminal kinase (JNK). H-Ras-transduced JNK2-deficient (Jnk2-/-) murine embryonic fibroblasts (MEFs) were severely inhibited in colony formation and growth in soft agar in vitro as well as in tumor formation in immunodeficient mice as compared with corresponding Jnk1-/- and wild-type MEFs. Accordingly, the RNA interference-based depletion of JNK2 form wild-type MEFs also resulted in defective Ras transformation. The extra barrier against H-Ras transformation in Jnk2-/- MEFs was not due to their inability to inactivate p53 signaling because all JNK2-deficient MEF lines had lost p19(Arf). Furthermore, expression of the E6 protein of the human papilloma virus failed to overcome the transformation defect. It could, however, be overcome by coexpression of H-Ras with the SV40 large T antigen or c-Myc. Surprisingly, the H-Ras-transduced JNK2-deficient MEFs exhibited higher activity of activator protein-1 and higher levels of c-Jun expression compared with H-Ras-transduced JNK1-deficient or wild-type cells, indicating that the key target of JNK2 during Ras transformation was divergent from activator protein-1. These results clearly show that a single kinase, JNK2, could control Ras transformation and thus point out a vulnerable control point that may prove important for the tumor development in general.
Xenobiotic induction of P-450 PB-4 (IIB1) and P-450c (IA1) and associated monooxygenase activities in primary cultures of adult rat hepatocytes (1991)

1. The long-term maintenance of metabolism of representative drugs and steroid hormone substrates by cytochromes P-450, and their inducibility, was investigated in primary cultures of adult rat hepatocytes. Collagenase-isolated cells were seeded on collagen-coated tissue culture dishes and cultured in Chee's essential media in the presence or absence of phenobarbital (PB, 0.75 mM, 96 h or continuously) and 3-methylcholanthrene (MC, 5 microM, 48 h) for up to 45 days. 2. Hepatic P-450-dependent metabolism of diazepam to its primary oxidized metabolite was inducible by PB both in vivo (monitored in isolated liver microsomes) and in cultured cells (up to 100% and 400% increases in the formation of temazepam and nordiazepam, respectively, after 25 days in culture). Hepatocyte microsomal androstenedione 16 beta-hydroxylase activity was also induced by PB treatment of the hepatocytes (350-650% increase in 20-day-old cells). 3. Western blot analysis revealed that immunoreactive P-450 form PB-4 (IIB1), which catalysed the N-demethylation of diazepam to yield nordiazepam as well as androstenedione 16 beta-hydroxylation when assayed in a purified enzyme system, was substantially elevated following PB treatment of the cultured cells. Similarly, MC induced 7-ethoxycoumarin O-deethylase activity (up to 2000% increase from 5 to 45 days) as well as immunoreactive P-450c (IA1) in the hepatocyte cultures. 4. These studies demonstrate that cytochrome P-450 activities can be maintained, and also induced, after extended periods of time in hepatocytes cultured using a simple collagen mixture as substrate and a commercially available tissue culture media. This culture system should provide an important tool for further studies of P-450-dependent xenobiotic metabolism in a well-defined, liver-derived cellular system.
Single-shot fluorescent lifetime imaging using a novel gated optical intensifier (2004)

Single-shot wide-field fluorescence lifetime imaging based on a novel gated optical intensifier with differential delays to each of four channels is reported. Single-shot FLIM is demonstrated with polymer films, multi-well plate arrays and biological tissue.
Transducer design with global parametric optimization (2002)

To design transducers or motors, it requires the analysis of a lot of parameters such as length, temperature, efficiency, weight, etc. To obtain the optimum results for given specifications, the solution is to analyze globally all the free parameters in one go, with an optimization algorithm based on the Matlab software including the optimization toolbox. A general module makes it possible then to get the optimum according to the constraints of the problem. In future, a module for each type of transducer or motor as well as a module for the driver will be developed.
Second Basket's Negative Impact (2008)

Second Basket limits the circulation of sci-entific documents and will substantially reduce scientific communication among researchers. For example, libraries or other document providers may send copies elec-tronically (e.g., in PDF format) only if the publisher of a particular work does not itself offer the work online in a clear manner and on reasonable terms. In principle, the Copyright Act strengthens the protection of authors ’ intellectual rights; however, most scientists do not want this protection if it comes at the expense of efficient and effec-tive circulation of scientific information. Effective science relies on effective com-munication, often quantified by the term “impact ” (1). Who is really protected by limiting the circulation of scientific knowledge? Publishers benefit most. The Copyright Act requires them to deliver scientific work on “reasonable terms, ” making possible a wide spectrum of business terms and con-ditions. Transfer agreements allow publish-ers to claim the copyright. A paradoxical situation emerges: National research foun-dations pay scientists to write papers, but the scientists must transfer the copyrights and then buy back their own papers in order to provide access to them. The international community should create a suitable frame-work for international copyrights in a net-worked world (2).
Assembly of Pure Silver‐Tungsten‐Oxide Frameworks from Nanostructured Solution Processable Clusters and Their Evolution into Materials with a Metallic Component (2010)

Silver-Tungsten-Oxide Frameworks: Isomerically pure forms of the unique isopolyoxotungstate system are incorporated into highly connected framework materials using Ag(I) as a linking unit. Thermal treatment of the materials leads to the formation of silver microparticles embedded in a tungsten oxide matrix. This novel synthetic approach promises to create a new class of nanostructured tungsten-silver-oxides with exciting physical properties, as well as exemplifies the potential for new frameworks based upon solution processable POM clusters.
Serendipitous SAD Solution for DMSO-Soaked SOCS2-ElonginC-ElonginB Crystals Using Covalently Incorporated Dimethylarsenic: Insights into Substrate Receptor Conformational Flexibility in Cullin RING Ligases (2015)

Suppressor of cytokine signalling 2 (SOCS2) is the substrate-binding component of a Cullin-RING E3 ubiquitin ligase (CRL) complex that targets phosphorylated hormone receptors for degradation by the ubiquitin-proteasome system. As a key regulator of the transcriptional response to growth signals, SOCS2 and its protein complex partners are potential targets for small molecule development. We found that crystals of SOCS2 in complex with its adaptor proteins, Elongin C and Elongin B, underwent a change in crystallographic parameters when treated with dimethyl sulfoxide during soaking experiments. To solve the phase problem for the new crystal form we identified the presence of arsenic atoms in the crystals, a result of covalent modification of cysteines by cacodylate, and successfully extracted anomalous signal from these atoms for experimental phasing. The resulting structure provides a means for solving future structures where the crystals must be treated with DMSO for ligand soaking approaches. Additionally, the conformational changes induced in this structure reveal flexibility within SOCS2 that match those postulated by previous molecular dynamics simulations. This conformational flexibility illustrates how SOCS2 can orient its substrates for successful ubiquitination by other elements of the CRL complex.
Controlled synthesis of skein shaped TiO2–B nanotube cluster particles with outstanding rate capability (2013)

Herein, we first report a facile synthetic route for preparing micron-sized particles comprising TiO(2)-B nanotubes, namely, skein shaped TiO(2)-B nanotube cluster particles with an ultra high surface area of 257 m(2) g(-1). The galvanostatic charge-discharge test showed that the hierarchical micron-sized particles composed of TiO(2)-B nanotubes with approximately 10 nm in diameter exhibited outstanding rate capability as well as high specific capacity.
An investigation of regularization for basis image reconstruction in spectral CT (2015)

Spectral CT adds an additional dimension of energy to the conventional CT imaging. As a result, more than one images are usually to be reconstructed. Conventionally, these images are reconstructed separately as isolated inverse problems, requiring minimum effort in adapting existing reconstruction algorithm. Joint reconstruction, on the other hand, takes advantages of the correlation among the images and seems to be more robust and less demanding on the scanning configuration. In this study, we develop an one-step optimization-based reconstruction method with regularization for the basis images. In a simulation study with a dual kVp scan consisting of two sequential limited-angle acquisition, the results have suggested that the method with the regularization improves the basis images by reducing the crosstalk in the bone regions and rendering more uniform textures in soft tissue regions.
Are sugar-sensing pathways involved in desiccation tolerance? (2003)

This chapter discusses the role of sugar-sensing pathways in desiccation tolerance. A hexokinase-dependent pathway and an abscisic acid-dependent pathway appear to be present in germinating seeds of cucumber and Medicago truncatula. Data suggest that both pathways are requisite to reinduce desiccation tolerance in emerged radicles.
The Effect of the Angiotensin-Converting Enzyme Inhibitor on Bone Health in Castrated Hypertensive Rats Is Mediated via the Kinin-Kallikrein System (2022)

ACEI decreased bone deterioration in both male and female hypertensive rats, and the bradykinin receptor blocker further decreased bone deterioration.
A Highly Diastereoselective Synthesis of α-Hydroxy-β-amino Acid Derivatives via a Lewis Acid Catalyzed Three-Component Condensation Reaction (2010)

A very efficient three-component synthesis of a series of syn α-hydroxy-β-amino esters, obtained in high diastereoselection and yield, was realized starting from an aldehyde, benzylamine, and the ketene silyl acetals derived from Ley's lactones. The synthetic protocol was optimized and the above compounds were obtained without the isolation of intermediates. The origin of the observed diastereoselection was investigated through a computational model of the key reaction step.
Using Machine Learning to Refine Black-Box Test Specifications and Test Suites (2008)

In the context of open source development or software evolution, developers often face test suites which have been developed with no apparent rationale and which may need to be augmented or refined to ensure sufficient dependability, or even reduced to meet tight deadlines. We refer to this process as the re-engineering of test suites. It is important to provide both methodological and tool support to help people understand the limitations of test suites and their possible redundancies, so as to be able to refine them in a cost effective manner. To address this problem in the case of black-box testing, we propose a methodology based on machine learning that has shown promising results on a case study.
Quantifying the Conceptual Combination Effect on Word Meanings (2019)

How do people understand concepts such as dog, aggressive\ndog, dog house or house dog? The meaning of a concept\ndepends crucially on the concepts around it. While this\nhypothesis has existed for a long time, only recently it has\nbecome possible to test it based on neuroimaging and quantify\nit using computational modeling. In this paper, a neural\nnetwork is trained with backpropagation to map attribute-\nbased semantic representations to fMRI images of subjects\nreading everyday sentences. Backpropagation is then\nextended to the attributes, demonstrating how word meanings\nchange in different contexts. Across a large corpus of\nsentences, the new attributes are more similar to the attributes\nof other words in the sentence than they are to the original\nattributes, demonstrating that the meaning of the context is\ntransferred to a degree to each word in the sentence. Such\ndynamic conceptual combination effects could be included in\nnatural language processing systems to encode rich contextual\nembeddings to mirror human performance more accurately.
Comparative Study between Analytical and Theo-retical Retrofitting of RC Beam with Different Resins Bonded CFRP Laminates (2021)

This thesis details experimental work and fi-nite part simulation of concrete beams retrofitted with carbon fiber strengthened compound (CFRP).The objectives of this study were to analyze the behavior of retrofitted beams to develop fi-nite part model describing the beams, supportive the fi-nite part model against the experimental results and eventual-ly investigation the influence of chemical compound resins(GP, ISO, Epoxy) on the sweetening of strengthening of retrofitted beams. The experimental results square measure performed to analyze the behavior of beams designed in such approach that either flexural or shear are going to be expected. The beams rectangle measure loaded at exploitation 2 pur-pose bending till cracks square measure developed. The beams were then blank and retrofitted with CFRP. Finally the beams were loaded till failure. The ANSYS program is employed to de-velop finite part models for simulation of behavior of beams.
Utsådda blommor räddar inte insekterna (2021)

Om vi vill rädda hotade insekts­arter är det miljöer med traditionella ängs­växter som vi behöver mer av, inte frö­blandningar av oklart ursprung från handeln. Det skriver flera debattörer.
Report of the Committee on Microbiological Examination of Foods (Microbiological Examination of Spices, Fermented Foods, and Fruit Juices) (1943)

Report of the Committee on Microbiological Examination of Foods (Microbiological Examination of Spices, Fermented Foods, and Fruit Juices), an article from American Journal of Public Health, Vol 33 Issue 6
Transcranial Doppler-detected cerebral embolic load during transcatheter aortic valve implantation (2011)

HITS are observed during all procedural intervals in TAVI. The embolic events appear to peak during DP. In our series, the overall cerebral embolic load did not differ between the transfemoral and the transapical access route. TCD monitoring in TAVI is useful to identify periods and manipulations associated with an increased cerebral embolic load and may help to further enhance the safety of this procedure.
Investigation of the experimental active control of a typical section airfoil using a trailing edge flap (1997)

This paper presents an experimental implementation of an active control system used to suppress °utter in a typical section airfoil.The H 2 optimal control system design is based upon experimental system identi¯cations of the transfer functions between three measured system variables: pitch, plunge, and °ap position and a single control signal which commands the °ap of the airfoil.Closed-loop response of the airfoil demonstrated gust-alleviation below the openloop °utter-boundary.In addition, the °utter boundary was extended by 12.4% through the application of active control.Cursory robustness tests demonstrate stable control for variations in °ow-speed of §10%.
Mechanism of Resource Virtualization in RCS for Multitask Stream Applications (2010)

Virtualization of logic, routing, and communication resources in recent FPGA devices can provide a dramatic improvement in cost-efficiency for reconfigurable computing systems (RCSs). The presented work is “proof-of-concept” research for the virtualization of the above resources in partially reconfigurable FPGA devices with a tile-based architecture. The following aspects have been investigated, prototyped, tested, and analyzed: (i) platform architecture for hardware support of the dynamic allocation of Application Specific Virtual Processors (ASVPs), (ii) mechanisms for run-time on-chip ASVP assembling using virtual hardware Components (VHCs) as building blocks, and (iii) mechanisms for dynamic on-chip relocation of VHCs to predetermined slots in the target FPGA. All the above mechanisms and procedures have been implemented and tested on a prototype platform—MARS (multitask adaptive reconfigurable system) using a Xilinx Virtex-4 FPGA. The on-chip communication infrastructure has been developed and investigated in detail, and its timing and hardware overhead were analyzed. It was determined that component relocation can be done without affecting the ASVP pipeline cycle time and throughput. The hardware overhead was estimated as relatively small compared to the gain of other performance parameters. Finally, industrial applications associated with next generation space-borne platforms are discussed, where the proposed approach can be beneficial.