gebhart/patrepeval huggingface dataset:
Tri-3-(2-butyl)-6-methylsalicylide. A novel, versatile tri-o-thymotide-based clathrate host having chiral centers (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTri-3-(2-butyl)-6-methylsalicylide. A novel, versatile tri-o-thymotide-based clathrate host having chiral centersJallal M. Gnaim, Bernard S. Green, Rina Arad-Yellin, K. Vyas, Judith T. Levy, Felix Frolow, and Philip M. KeehnCite this: J. Am. Chem. Soc. 1992, 114, 5, 1915–1916Publication Date (Print):February 1, 1992Publication History Published online1 May 2002Published inissue 1 February 1992https://doi.org/10.1021/ja00031a075RIGHTS & PERMISSIONSArticle Views103Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (317 KB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
The combination of low fat-free mass and high fat mass is related to functional outcome and systemic inflammation in patients with COPD (2014)

Background: In patients with COPD, low fat-free mass index(FFMI) is related to worse lung function and exercise capacity, whereas adiposity contributes to functional limitation and systemic inflammation. The combination of low FFMI with high fat mass index(FMI) results in more disability in the elderly, yet its effects in COPD remain unknown. Methods: Patients from the ECLIPSE COPD cohort were stratified according to body composition (FFMI lower than 10 th , and FMI higher than 90 th percentile of the age, sex and BMI-specific values from the general population of the UK Biobank) and classified as low FFMI, and high FMI, respectively. Baseline lung function, health status(SGRQ), 6-minute walking distance(6MWD) and elevated inflammatory markers(&gt;95 th percentile of values in healthy non-smokers)were recorded. Results: In 2000 participants (63.5±7.1 yrs, 66%men), FEV 1 , SGRQscore and 6MWD were significantly different(p&lt;0.05 for each comparison) between patients grouped by FFMI and FMI(Table). The combined low FFMI and high FMI had the lowest FEV 1 and 6MWD, the highest SGRQscore and 1.87 (95%CI,1.22-2.86,p&lt;0.01) odds of ≥2 elevated inflammatory markers after adjustments for age, sex, pack-years and FEV 1 vs normal. Conclusion: Concurrent high FMI was related to deterioration of clinically relevant outcomes and systemic inflammation in patients with COPD and low FFMI. (n) Normal(1009) Low FFMI(485) High FMI(309) Low FFMI&amp;high FMI(197) FEV1(%pred) 50(39,63) 42(33,58) 47(37,61) 39(31,56) SGRQ 48(33,63) 51(34,66) 50(36,63) 56(41,68) 6MWD(m) 398(317,465) 380(302,458) 382(310,452) 350(267,426) Support: GlaxoSmithKline SCO104960, NCT00292552 and ERS STRTF2013-2399.
The Effect of Electrode Configuration on the Unipolar His‐Bundle Electrogram (1989)

Although "unipolar electrograms" recorded from the His-bundle position have been used to help position catheters for His-bundle ablation, the techniques used to record such electrograms have not been standardized. The effects of five anode locations (right chest wall, anterior chest wall, left chest wall, posterior chest wall, and inferior vena cava) on unipolar atrial, His bundle and ventricular electrograms recorded from the His-bundle position were examined in ten patients undergoing clinical electrophysiology studies. Electrograms were recorded at filter settings of 50-500 as well as 0.05-1000 Hz. The location of the anode had no consistent effect on the amplitude, duration or morphology of any of the electrograms at either filter setting, but signals recorded with the inferior vena cava anode had the highest signal-to-noise ratio. A filter setting of 50-500 Hz decreased the amplitude of atrial (0.72 to 0.33 mV-P less than 0.01), His bundle (0.38 vs 0.32 mV-P less than 0.01) and ventricular electrograms (3.71 vs 2.01 mV-P less than 0.001) compared to a filter setting of 0.05-1,000 Hz. The filter setting did not affect electrogram duration. We concluded that the use of an electrode catheter in the inferior vena cava as the anode when recording "unipolar electrograms" from the His-bundle position yields a better signal-to-noise ratio than a skin patch on the chest and appears to be the optimal method for recording unipolar electrograms.
Ligands for programmed cell death 1 gene in patients with systemic lupus erythematosus. (2007)

PD-L2 47103 T may be associated with susceptibility to SLE in Taiwan.
Periodontal pocket irrigation as adjunctive treatment. (1997)

The emphasis in periodontal treatment generally has shifted in recent years from periodontal surgery towards periodontal medicine. Because the major periodontal disease group is the chronic inflammatory group, and the major direct cause of chronic inflammation is dental plaque, much of the new research is directed at more ergonomic and economic means of plaque control that have the efficacy of traditional methods. As a result, the field of plaque chemotherapy is expanding concurrent with the modes of application of anti-plaque chemical agents to their interdental and subgingival sites of intended action. Since the rediscovery of subgingival irrigation some 15 years ago, the technique has been shown to provide an efficient means of subgingival application of anti-plaque agents, and it has also been used to apply anti-inflammatory compounds. It was never intended to stand alone. It was and is meant to be used as an adjunct to professional debridement, but one that simplifies home-care oral hygiene for the patient. This, indeed, is part of the aim of all chemical anti-plaque adjunctive therapy. It requires the use of appropriate anti-plaque agents in sufficient concentration and with sufficient periodicity to be clinically effective. It is only ineffective if dose or periodicity is inadequate, or if mechanical plaque control is unrealistically good--that is, unlikely to be maintained long term by the majority of patients. Subgingival irrigation enables the patient for the first time to deal with bursts of periodontitis activity when professional help is not readily available. Although irrigation per se may dilute plaque toxins, it is still clinically inadequate without a suitable chemical adjunct. Subgingival irrigation with a suitable antimicrobial agent currently constitutes an effective adjunct to the simplified oral hygiene regimen that does not require unrealistic levels of interdental or subgingival home-care cleaning by the patient.
Heparin-Induced Thrombocytopenia and Thrombosis: Detection and Specificity of a Platelet-Aggregating IgG (1985)

A 46-year-old female who died as a result of thrombocytopenia associated with multiple arterial occlusions and septicemia while on heparin therapy was found to have a platelet-aggregating factor present in several plasma samples and in a sample of serum. This factor was subsequently shown to be an IgG with aggregating properties toward normal platelets that were enhanced by, but not dependent on, the presence of heparin. Further studies showed that heparin was unlikely to have acted as a hapten in initiating the IgG production but that its role was significant in aggravating the ensuing arterial thrombosis. The necessity of substitution of heparin with alternative anticoagulant/antithrombotic therapy to avoid the worst sequelae of this potentially catastrophic syndrome is discussed.
A Near-Surface Microstructure Sensor System Used during TOGA COARE. Part II: Turbulence Measurements (1999)

New techniques developed for near-surface turbulence measurements during the Tropical Ocean Global Atmosphere (TOGA) Coupled Ocean-Atmosphere Response Experiment (COARE) employ a difference in spatial scales of turbulence and surface waves. According to this approach, high relative speed of the measurements provides separation of the turbulence and surface wave signals. During the TOGA COARE field studies, highresolution probes of pressure, temperature, conductivity, fluctuation velocity, and acceleration were mounted on the bow of the vessel at a 1.7-m depth in an undisturbed region ahead of the moving vessel. The localization in narrow frequency bands of the vibrations of the bow sensors allows accurate calculation of the dissipation rate. A coherent noise reduction algorithm effectively removes vibration contamination of the velocity dataset. Due to the presence of surface waves and the associated pitching of the vessel, the bow probes ''scanned'' the near-surface layer of the ocean. Contour plots calculated using the bow signals provide a spatial context for the analysis of near-surface turbulence. A fast-moving free-rising profiler equipped by similar probes sampled the near-surface turbulence during stations. Theory of the three-component electromagnetic velocity sensor and examples of data obtained by bow sensors and free-rising profiler are also presented in this paper.
Карбоангидраза как маркер активности остеокластов при репарации зоны перелома длинной кости (2012)

In an experimental model of long bone fractures studied osteoclastic activity in the fracture zone. We used histological staining methods and histochemical staining with antibodies to carbonic anhydrase type II. It is shown that the use of histochemical staining to carbonic anhydrase type II cells is promising for the evaluation of osteoclastic activity in bone tissue. Application of this technique significantly simplifies the morphological study, allows a clear differentiation of osteoclastic cells.
A maximum frequency detector for Doppler blood velocimeters (1979)

The clinical information available from ultrasonic Doppler blood velocimeters may be analysed in several ways, spectral analysis probably being the best. This is, however, a relatively expensive technique when compared with the cost of commerically available Doppler velocimeters. A large part of the diagnostic information present can be obtained from the maximum blood velocity in the vessel at any one time. A relatively inexpensive analogue method of extracting this information from the Doppler signal is described, and the preliminary results obtained on signals derived from peripheral arteries are discussed.
The synthesis of oligosaccharides containing internal and terminal Galβ1-3GlcNAcβ fragments (2015)

Synthesis of oligocaccharides Galβ1-3GlcNAcβ-sp, GlcNAcβ1-3Galβ1-3GlcNAcβ-sp, Galβ1-3GlcNAcβ1-3Galβ1-3GlcNAcβ-sp, Galβ1-3GlcNAcβ1-3Galβ1-4GlcNAcβ-sp, Galβ1-3GlcNAcβ1-6Galβ1-4GlcNAcβ-sp (sp = O(CH2)3NH2 or O(CH2)2NH2) was carried out using glycosylation by N-Troc-protected derivatives of glycosamine or disaccharide Galβ1-3GlcN.
Effect of Milk Concentration on Heat-Induced, pH-Dependent Dissociation of Casein from Micelles in Reconstituted Skim Milk at Temperatures between 20 and 120 °C (1998)

The effect of pH, milk concentration, heating temperature, and heating time on the dissociation of casein from the micelles in reconstituted skim milk was investigated. For the 10% total solids milk samples, low levels of casein were rendered soluble at pH below 6.7 regardless of heating temperature, whereas increasing levels of casein were solubilized as the pH was increased from 6.7 to 7.1. The quantity of soluble casein increased with temperature to a maximum dissociation at about 60−80 °C, decreased as the temperature was raised to 100 °C, and then increased as the temperature was raised further. The dissociation behavior of αs-casein and β-casein showed similar dependence on temperature to that of the total casein. In contrast, the dissociation of κ-casein increased with increasing temperature over the entire temperature range studied. Most casein dissociation occurred during the first minutes of heating, with little further change on prolonged heating. As the milk was concentrated, a higher level of dissociation of casein, particularly κ-casein, was observed at lower pH and at higher temperatures, particularly above 80 °C. Keywords: Casein micelles; dissociation; heat treatment; reconstituted skim milk; concentrated skim milk
Substrate scope and synthetic applications of the enantioselective reduction of α-alkyl-β-arylenones mediated by Old Yellow Enzymes (2013)

The ene-reductases mediated bioreduction of a selection of open-chain α-alkyl-β-aryl enones afforded the corresponding saturated α-chiral ketones in high yield and optical purity in several cases. The stereo-electronic requirements of the reaction have been investigated, considering the nature and location of substituents on the aromatic ring as well as the steric hindrance at the α-position and adjacent to the carbonyl functionality. The general considerations drawn allow us to guide the design of α,β-unsaturated ketones to be employed as substrates of ene-reductases in future preparative applications. An interesting case of orthogonality between enzyme-based and substrate-based stereocontrol within the highly homologous ene-reductases from Saccharomyces species (OYE1-3) has been reported and rationalized with the help of computational docking studies. Furthermore, to demonstrate the synthetic versatility of the reaction, the key chiral precursors of biologically active compounds such as (2'R)-stenusines and (S)-iopanoic acid were obtained. The very robust protocol allowed us to run the reactions on preparative scale in quantitative yields, with a simple work-up and no chromatographic purification steps.
An experimental and theoretical analysis of double-diffused MOS transistors (1975)

An experimental and theoretical study of double-diffused MOS transistors (DMOST's) has been made. A simple, analytic two-transistor model gives insight into DMOS device physics as well as predicting DMOST characteristics. Both the model and experimental results show that three distinct regions of operation exist: short-channel control, long-channel control, and carrier velocity saturation control. Quantitative criteria are established for judging the region of operation as a function of device parameters and terminal voltages. A DMOST may be optimized to have the same d.c. characteristics as its short-channel component transistor over most of its operating range. A two-transistor model suitable for Computer-Aided Circuit Design (CAD) is also presented.
Models for Minimum Liquid Fluidization Velocity of Gas-Liquid Fluidized Beds. (2001)

The gas-perturbed liquid model of Zhang et al. (1995) is modified in an effort to improve its prediction of the minimum liquid velocity of fluidization, Ulmf, of a bed of solid particles in the presence of a low or moderate cocurrent flow of gas. Variants of the model are considered where the buoyancy term is based on the gas-liquid mixture, instead of the liquid alone, and with the frictional pressure gradient given by several alternative equations to the Ergun equation employed in the original gas-perturbed liquid model. All versions of the model provide similar dependence on such factors as gas velocity, particle diameter, particle density and liquid viscosity as those seen experimentally. The mixture buoyed equation with the drag based on an equation suggested by Foscolo et al. (1983) gives improved predictions over the original Zhang et al. (1995) model, but the best overall agreement is with buoyancy based on the liquid alone and the first term in the drag equation with the Carman (1937) constant of 180 instead of Ergun's 150. The predictions are sensitive to the minimum fluidization voidage, which is measured, assumed, or estimated. Further work is required to investigate minimum liquid fluidization velocities experimentally for particles of density closer to that of the liquid, and for high-viscosity liquids.
The AP1000{sup R} nuclear power plant innovative features for extended station blackout mitigation (2012)

Station Blackout (SBO) is defined as 'a condition wherein a nuclear power plant sustains a loss of all offsite electric power system concurrent with turbine trip and unavailability of all onsite emergency alternating current (AC) power system. Station blackout does not include the loss of available AC power to buses fed by station batteries through inverters or by alternate AC sources as defined in this section, nor does it assume a concurrent single failure or design basis accident...' in accordance with Reference 1. In this paper, the innovative features of the AP1000 plant design are described with their operation in the scenario of an extended station blackout event. General operation of the passive safety systems are described as well as the unique features which allow the AP1000 plant to cope for at least 7 days during station blackout. Points of emphasis will include: - Passive safety system operation during SBO - 'Fail-safe' nature of key passive safety system valves; automatically places the valve in a conservatively safe alignment even in case of multiple failures in all power supply systems, including normal AC and battery backup - Passive Spent Fuel Pool cooling and makeup water supply during SBO - Robustness ofmore » AP1000 plant due to the location of key systems, structures and components required for Safe Shutdown - Diverse means of supplying makeup water to the Passive Containment Cooling System (PCS) and the Spent Fuel Pool (SFP) through use of an engineered, safety-related piping interface and portable equipment, as well as with permanently installed onsite ancillary equipment. (authors)« less
Response of Man to Infection with Vibrio cholerae. I. Clinical, Serologic, and Bacteriologic Responses to a Known Inoculum (1974)

Journal Article Response of Man to Infection with Vibrio cholerae. I. Clinical, Serologic, and Bacteriologic Responses to a Known Inoculum Get access Richard A. Cash, Richard A. Cash From the Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar Stanley I. Music, Stanley I. Music From the Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar Joseph P. Libonati, Joseph P. Libonati From the Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar Merrill J. Snyder, Merrill J. Snyder From the Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar Richard P. Wenzel, Richard P. Wenzel From the Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar Richard B. Hornick Richard B. Hornick From the Division of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Infectious Diseases, Volume 129, Issue 1, January 1974, Pages 45–52, https://doi.org/10.1093/infdis/129.1.45 Published: 01 January 1974 Article history Received: 16 March 1973 Revision received: 05 July 1973 Published: 01 January 1974
Advances in Radiobiological Studies Using a Microbeam (2009)

Recent developments in microbeam technology have made drastic improvements in particle delivery, focusing, image processing and precision to allow for rapid advances in our knowledge in radiation biology. The unequivocal demonstration that targeted cytoplasmic irradiation results in mutations in the nuclei of hit cells and the presence of non-targeted effects, all made possible using a charged particle microbeam, results in a paradigm shift in our basic understanding of the target theory and other radiation-induced low dose effects. The demonstration of a bystander effect in 3D human tissue and whole organisms have shown the potential relevance of the non-targeted response in human health. The demonstration of delayed mutations in the progeny of bystander cells suggest that genomic instability induced following ionizing radiation exposure is not dependent on direct damage to cell nucleus. The identification of specific signaling pathways provides mechanistic insight on the nature of the bystander process.
The primary structure of hevamine, an enzyme with lysozyme/chitinase activity from Hevea brasiliensis latex (1991)

The primary structure of hevamine, an enzyme with lysozyme/chitinase activity from Hevea brasiliensis latex, has been determined predominantly with conventional non‐automatic methods. The positions of three disulfide bridges have been determined. The sequence has about 60% identity with that of a chitinase from cucumber and 95% with the N‐terminal sequence of the lysozyme/chitinase of Parthenocissus quinquefolia . The half‐cystine residues in hevein and cucumber chitinase are located at identical positions. Hevamine is a basic protein from the lutoids (vacuoles) of rubber latex and may have a role in plugging the latex vessels and cessation of latex flow. The differences in cellular location, charge properties and sequence between hevamine and cucumber chitinase are similar to those between class I and class II chitinases from tobacco and other plant species.
Buccal Mucosa Bleeding Time Is Prolonged in Canine Models of Primary Hemostatic Disorders (1993)

Bleeding times are reported in many studies using canine models, with a variety of techniques employed to adapt these tests for dogs. We evaluated a canine model of template bleeding time, the buccal mucosa bleeding time (BMBT), by examining the test's sensitivity and specificity for defects of primary hemostasis. We examined thirty-five dogs having defined defects of either primary hemostasis (Types I, II, III von Willebrand's disease, thrombasthenia, thrombopathia) or secondary hemostasis (hemophilia A and B, Factor VII deficiency). Comparisons of BMBT and cuticle bleeding time were made in a subset of these dogs. All dogs having primary hemostatic disorders had long BMBT, and all factor deficient dogs had BMBT within normal range. The BMBT in canine models appears to be a specific and sensitive test of primary hemostasis; suitable for evaluating factors affecting template bleeding time and potential efficacy and thrombogenicity of treatment regimens.