gebhart/patrepeval huggingface dataset:
INFLUENCE OF WALL CONDUCTION ON MIXED CONVECTION HEAT TRANSFER IN EXTERNALLY FINNED PIPES (1995)

Abstract The influence of wall heat conduction on laminar mixed convection in externally finned vertical pipes are investigated numerically. Buoyancy in both aiding and opposed modes is considered. Results are presented in terms of the streamwise variation of the fluid bulk temperature and tube-side Nusselt number, axially averaged and periodically fully developed Nusselt number values, and axial velocity and temperature profiles. For opposed flows, buoyancy forces decrease the overall heat transferred to the fluid, while for buoyancy-aided flows, buoyancy causes an enhancement in the overall heat transferred to the fluid. Inclusion of longitudinal wall conduction increases the heat transfer to the fluid and enhances the effects of buoyancy.
Fatigue crack growth under mixed mode loading of 18CRMO4 steel (2012)

The mechanical properties of 18CrMo4 steel under multiaxial stress field loading have been investigated. Especially crack growth rate analysis under mixed model crack loading was carried out in this work. A numerical model result of fatigue crack growth and the results from experimental studies using two different specimen geometries and loading conditions are discussed. The main aim of this work is to develop mathematical model in order to predict the response of materials and state the crack propagation under mixed mode fatigue loading typical for wide range of applications.
포스터 발표 : 수질 환경 분야(PW) ; 2012년 농업용수 수질측정망조사 결과 분석 (2013)

농업용수 수질측정망조사는 전국의 주요 농업용 저수지를 대상으로 매년 4회 정기적으로 실시하는 조사이다. 조사내용은 대상 유역의 오염원과 환경기초시설현황, COD T-N, T-P 등 주요 수질항목들이다. 조사결과는 현재의 수질현황 파악과 향후 수질관리 정책 수립, 수질개선사업의 기초자료로 활용되고 있다. 2012년 봄철 장기가뭄, 여름철 이상고온, 3개 태풍 연속상륙 등 이상기후가 빈번해지면서 농업용수 관리기준인 호소 수질기준 Ⅳ등급(농업용수 관리기준)을 초과한 시설은 16.7%로 전년대비 2.9%가 증가 하였으며 평균 COD농도는 5.6 mg/l로 조사되었다. 지역별 수질현황은 대전과 충남지역이 평균 COD 7.4 mg/l, Ⅳ등급 초과시설이 34.9%로 가장 높았다. 반면에 수질이 가장 좋은 지역은 강원지역으로 평균 COD 3.7 mg/l로 조사되었다. 권역별 호소 Ⅳ등급 수질기준 초과율은 금강권역이 21.2%로 가장 높았으며 한강(17.6%), 낙동강(17.4%)순으로 나타났다. 권역별 평균 COD는 금강권역 6.4 mg/l, 영산 강권역 5.8 mg/l, 낙동강권역이 5.7mg/l로 농업용수 관리기준 이하의 수질을 보였다. 조사시기별 수질현황은 2분기(4∼6월)가 가장 나빴으며 원인은 장기간에 걸친 봄가뭄, 짧은 장마 이후 고수온과 일조량 증가 등으로 판단된다. 1분기(1∼3월)에 수질이 가장 양호하였으며 이는 낮 은 수온, 외부 오염원 유입량 감소, 안정된 수층 등의 영향으로 나타났다. 측정망시설의 주요 오염 원은 토지계(44.4%), 생활계(27.6%), 축산계(27.5)순으로 나타났다. 최근 10년간 오염원별 변화는 비점오염원인 토지계가 지속적으로 증가하고 생활계가 감소하는 추세를 보이고 있어 농촌비점오염 원 관리의 필요성이 증대되고 있다. 한편, 호소 Ⅳ등급 초과시설인 경우, 주오염원은 축산계 (49.3%)와 생활계(38.4%)로 나타나 보다 적극적인 점오염원 관리가 시급한 실정이다. 저수지의 영양상태는 R.V Vollenweider 방법와 한국형 부영양화지수(TSIKO)에 따라 분류하였다. R.V Vollenweider 방법을 이용한 호소의 영양상태는 중영양이 50.2%, 중부영양 37.8%, 부영양이 7.0%, 빈영양이 4.1%로 나타났다. TSIKO 에 의한 영양상태는 부영양으로 나타났다. 최근 10년간 농업용 저수지의 영양상태도 부영양상태로 조류발생에 취약한 것으로 나타났다. 농식·품부·환경부에서는 호소 Ⅳ등급(COD, T-P기준－삭제(T-N도 고려)) 초과시설에 대해 매년 중점관리 농업용 호소로 지정·관리하여 수질오염 감시 및 방지활동을 위한 다각적인 노력을 하고 있다. 농업용 저수지의 수질관리의 어려운 점은 농촌지역에 위치하여 생활하수를 처리할 수 있는 마을 하수도 부족과 가축분뇨에 대한 관리미흡으로 강우시 농경 비점오염원으로 유입되기 때문이다. 그 결과 호소 Ⅳ등급 초과시설의 주오염원이 생활계와 축산계로 조사되었다. 농업용저수지의 수질개선사업의 효율성을 높이기 위해서는 유입오염원 대책이 우선되어야 한다. 중점관리시설의 주오염원인 축산계 비점오염물질과 생활하수처리를 위한 마을하수도 설치가 우선 되어야 한다. 또한 농업 비점오염물질 저감을 위한 정책 발굴이 적극적으로 고려되어야 한다.
ChemInform Abstract: MIXED‐VALENCE POLY(VANADIC ACID) GELS (1982)

Abstract Durch Polymerisierung von Decavanadinsäure werden hochkondensierte Spezies (M, z 2‐ 10′) erhalten.
PHYSICAL MECHANISMS CAUSING NONLINEAR MICROWAVE LOSSES IN HIGH-TC SUPERCONDUCTORS (1997)

We present a short overview of the mechanisms of microwave losses in high-Tc superconductors with special attention to high-power losses. An impedance plane analysis is used as a tool for quantitative comparison of the experimental data to the models. We discuss several models of nonlinear microwave performance of high-Tc superconductors, including coupled-grain and rf-critical state models, and estimate their characteristic time scales. 1.
Complement activation by candidate biomaterials of an implantable microfabricated medical device (2011)

Implantable devices realized by microfabrication have introduced a new class of potential biomaterials whose properties would need to be assessed. Such devices include sensors for measuring biological substances like glucose. Thus, 14 different candidate materials intended for design of such a device were investigated with respect to their complement activation potential in human serum. The fluid-phase activation was measured by the products C4d, Bb, C3bc, and the terminal complement complex (TCC), whereas solid-phase activation was measured by deposition of TCC on the material surfaces. No fluid-phase activation was found for materials related to the capsule, carrier, or sealing. Fluid-phase activation was, however, triggered to a various extent in three of the four nanoporous membranes (cellulose, polyamide, and aluminium oxide), whereas polycarbonate was rendered inactive. Solid-phase activation discriminated more sensitively between all the materials, revealing that the capsule candidate polydimethylsiloxane and sealing candidate silicone 3140 were highly compatible, showing significantly lower TCC deposition than the negative control (p < 0.01). Three of the candidate materials were indifferent, whereas the remaining nine showed significantly higher deposition of TCC than the negative control (p < 0.01). In conclusion, complement activation, in particular when examined on the solid phase, discriminated well between the different candidate materials tested and could be used as a guide for the selection of the best-suited materials for further investigation and development of the device.
An efficient method for finding a minimal feedback arc set in directed graphs (2003)

Finding a minimum cardinality set of arcs that breaks all cycles in a directed graph is important in the study of large-scale systems with feedback. This problem is viewed as finding an ordering for the vertices in a graph such that the set of arcs from higher to lower numbered vertices becomes minimum. After partitioning the graph into strongly and bi-connected components, depth-first search traversing is performed on each component. Reordering is done so that only backward arcs become negative arcs. An efficient cutting technique to reduce the negative arcs further is then described. Experimental results for a number of directed graphs are given.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Surface transfer doping of diamond by MoO3: A combined spectroscopic and Hall measurement study (2013)

Surface transfer doping of diamond has been demonstrated using MoO 3 as a surface electron acceptor material. Synchrotron-based high resolution photoemission spectroscopy reveals that electrons are transferred from the diamond surface to MoO 3 , leading to the formation of a sub-surface quasi 2-dimensional hole gas within the diamond. Ex-situ electrical characterization demonstrated an increase in hole carrier concentration from 1.00 10 13 /cm 2 for the air-exposed hydrogen-terminated diamond surface to 2.16 10 13 /cm 2 following MoO 3 deposition. This demonstrates the potential to improve the stability and performance of hydrogen-terminated diamond electronic devices through the incorporation of high electron affinity transition metal oxides.
Cyclogram Planarity is Preserved in Upward Slope Walking (1999)

In a recent paper [1] Borghese et al. demonstrated that 4D pelvis-thigh-shank-foot cyclograms of human locomotion are surprisingly planar, if the segmental elevation angles rather than the traditional inter-segmental angles are used. In this work, we demonstrate that the planarity of elevation angle cyclograms is preserved even for slope walking, within a 15 degree range. Methods Three healthy adult volunteers (1 female, 2 male, ages 20-36) participated in this study after giving informed consent. The subjects were asked to walk at freely chosen speeds on three surface inclinations: 0 degrees, 8 degrees, and 15degrees. Each subject performed 20 trials on each slope angle. A variable inclination ramp (366 cm L x 60 cm W) was constructed for this purpose. We used a single camera system from Vision 1 Corp. to record sagittal plane position data at 30 Hz for five reflective markers attached to bony landmarks [1]: anterior superior iliac crest, greater trochanter, lateral femur epicondyle, lateral malleolus, and fifth metatarsophalangeal joint. At each time instant, the elevation angles of the thigh, shank, and foot were extracted from the marker positions and plotted in a 3 dimensional space. Over a complete gait cycle, these points form a curve- the cyclogram. Pelvis elevation angles were also extracted but were ignored here for 3D illustration purposes. However, the results hold when the pelvis elevation angles are included.
Exploiting information access patterns for context-based retrieval (2002)

In order for intelligent interfaces to provide proactive assistance, they must customize their behavior based on the user's task context. Existing systems often assess context based on a single snapshot of the user's current activities (e. g., examining the content of the document that the user is currently consulting). However, an accurate picture of the user's context may depend not only on this local information, but also on information about the user's behavior over time. This paper discusses work on a recommender system, Calvin, which learns to identify broader contexts by relating documents that tend to be accessed together. Calvin's text analysis algorithm, WordSieve, develops term vector descriptions of these contexts in real time, without needing to accumulate comprehensive statistics about an entire corpus. Calvin uses these descriptions (1) to index documents to suggest them in similar future contexts and (2) to formulate contextbased queries for search engines. Results of initial experiments are encouraging for the approach's improved ability to associate documents with the research tasks in which they were consulted, compared to methods using only local information. This paper sketches the project goals, the current implementation of the system, and plans for its continued development and evaluati.
Resting state default‐mode network connectivity in early depression using a seed region‐of‐interest analysis: Decreased connectivity with caudate nucleus (2009)

The present study is the first to investigate resting-state DMN in the early stages of treatment-seeking for depression. Depressed subjects had decreased connectivity between the P/PCC and the bilateral caudate, regions known to be involved in motivation and reward processing. Deficits in DMN connectivity with the caudate may be an early manifestation of major depressive disorder.
PKA Type IIα Holoenzyme Reveals a Combinatorial Strategy for Isoform Diversity (2007)

The catalytic (C) subunit of cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) is inhibited by two classes of regulatory subunits, RI and RII. The RII subunits are substrates as well as inhibitors and do not require adenosine triphosphate (ATP) to form holoenzyme, which distinguishes them from RI subunits. To understand the molecular basis for isoform diversity, we solved the crystal structure of an RIIalpha holoenzyme and compared it to the RIalpha holoenzyme. Unphosphorylated RIIalpha(90-400), a deletion mutant, undergoes major conformational changes as both of the cAMP-binding domains wrap around the C subunit's large lobe. The hallmark of this conformational reorganization is the helix switch in domain A. The C subunit is in an open conformation, and its carboxyl-terminal tail is disordered. This structure demonstrates the conserved and isoform-specific features of RI and RII and the importance of ATP, and also provides a new paradigm for designing isoform-specific activators or antagonists for PKA.
COENZYME Q. VI. ETHOXY HOMOLOGS OF COENZYME Q10. ARTIFACT OF ISOLATION (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCOENZYME Q. VI. ETHOXY HOMOLOGS OF COENZYME Q10. ARTIFACT OF ISOLATIONBruce O. Linn, Nelson R. Trenner, Clifford H. Shunk, and Karl FolkersCite this: J. Am. Chem. Soc. 1959, 81, 5, 1263–1264Publication Date (Print):March 1, 1959Publication History Published online1 May 2002Published inissue 1 March 1959https://pubs.acs.org/doi/10.1021/ja01514a071https://doi.org/10.1021/ja01514a071research-articleACS PublicationsRequest reuse permissionsArticle Views45Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Structure and mechanism of the oestrogen receptor (2003)

We have determined the structures of the oestrogen receptor ligand-binding domain in complex with a range of ligands and with fragments of co-regulator proteins. These structures provide insights into the structural mechanisms underlying the receptor's complex pharmacological properties and how the conformation of the receptor modulates its ability to recruit co-regulators that are necessary for transcriptional activation.
Zebrafish (Danio rerio) neural crest cell RNA-sequencing (2020)

RNA-sequencing of neural crest cells collected from 36 and 72 hpf Gt(foxd3:mCherry);Tg(sox10:mEGFP) embryos
A framework for OpenGL client-server rendering (2012)

We present a software framework that facilitates the development of OpenGL applications utilizing the limited GPU capacities of a portable client in combination with the high-end rendering hardware on a server. The resulting web-application uses standard technologies and can be run on a wide variety of devices, such as smart phones, tablets and laptops. The framework is designed to make it simple changing an existing OpenGL application into a web-application, gradually adding client-side rendering. Furthermore, it provides automatic network scaling to provide interactivity even on poor connections.
C-type cytoplasmic male sterility in corn (2007)

It is shown experimentally that late break of anthers in C-type CMS corn is controlled by modifier genes, probably of complementary action, localized in the cytoplasm of the maternal line as well.
Multi locus fingerprinting ofListeria monocytogenesby sequence-specific labeling of DNA probes combined with array hybridization (2003)

We have developed an alternative multi locus sequence typing (MLST) approach that targets the variable genetic changes directly in a DNA array format. Our approach is based on DNA array hybridization in combination with sequence-specific labeling of oligonucleotide probes. Listeria monocytogenes was chosen for the development and evaluation of the assay. The genes hlyA, iap, flaA, inlA and actA were targeted. Twenty-nine suitable probe regions were identified within these genes. The DNA array results from 32 different strains were compared to serotype and amplified fragment length polymorphism data. This comparison showed that our DNA array method gave good discrimination between the strains analyzed. In conclusion, the DNA array-based MLST method is a promising tool for fingerprint bacteria.
Cpipe: a shared variant detection pipeline designed for diagnostic settings (2015)

Abstract The benefits of implementing high throughput sequencing in the clinic are quickly becoming apparent. However, few freely available bioinformatics pipelines have been built from the ground up with clinical genomics in mind. Here we present Cpipe, a pipeline designed specifically for clinical genetic disease diagnostics. Cpipe was developed by the Melbourne Genomics Health Alliance, an Australian initiative to promote common approaches to genomics across healthcare institutions. As such, Cpipe has been designed to provide fast, effective and reproducible analysis, while also being highly flexible and customisable to meet the individual needs of diverse clinical settings. Cpipe is being shared with the clinical sequencing community as an open source project and is available at http://cpipeline.org .
YB-1 Structure/Function Relationship in the Packaging of mRNPs and Consequences for Translation Regulation and Stress Granule Assembly in Cells (2022)

From their synthesis in the nucleus to their degradation in the cytoplasm, all mRNAs have the same objective, which is to translate the DNA-stored genetic information into functional proteins at the proper time and location. To this end, many proteins are generally associated with mRNAs as soon as transcription takes place in the nucleus to organize spatiotemporal regulation of the gene expression in cells. Here we reviewed how YB-1 (YBX1 gene), one of the major mRNA-binding proteins in the cytoplasm, packaged mRNAs into either compact or extended linear nucleoprotein mRNPs. Interestingly the structural plasticity of mRNPs coordinated by YB-1 could provide means for the contextual regulation of mRNA translation. Posttranslational modification of YB-1, notably in the long unstructured YB-1 C-terminal domain (CTD), and/or the protein partners of YB-1 may play a key role in activation/inactivation of mRNPs in the cells notably in response to cellular stress.
Landslide inventory updating by means of Persistent Scatterer Interferometry (PSI): the Setta basin (Italy) case study (2014)

This paper illustrates the contribution of Persistent Scatterer SAR Interferometry (PSInSAR) technique to landslide detection, using interferometric data acquired in C-band by European remote-sensing satellite (ERS) 1/2 and environmental satellite (ENVISAT) satellites. The main purpose is to update a pre-existing landslide inventory map, by changing or confirming the landslide geometry and state of activity and eventually, identifying new phenomena.This work presents an application of satellite remote sensing to analyse ground displacement movements in the Setta basin, located on the northern Appennine (Bologna province, Italy) and extended up 268 km2.The proposed methodology, resting upon pre-existing works already consolidated in the scientific community, combines interferometric measures with aerial imagery and other auxiliary data, in order to detect landslide indicators, finally validated with field surveys. The use of an activity matrix allows the identification of the state of activity of landslide phenomena with respect to the velocity of the radar displacement rates. Field validations are carried out in the areas that are more relevant because of the highest ground velocities and the presence of structures extensively affected by ground movements.The final updated landslide database of the Setta basin, based on Persistent Scatterer Interferometry analysis and in situ checks, consists of 1550 landslides, 236 of which have persistent scatterer information.
Plant–Virus Interactions (2008)

A variety of techniques have been used to examine plant viral genomes, the functions of virus-encoded proteins, plant responses induced by virus infection and plant-virus interactions. This overview considers these technologies and how they have been used to identify novel viral and plant proteins or genes involved in disease and resistance responses, as well as defense signaling. These approaches include analysis of spatial and temporal responses by plants to infection, and techniques that allow the expression of viral genes transiently or transgenically in planta, the expression of plant and foreign genes from virus vectors, the silencing of plants genes, imaging of live, infected cells, and the detection of interactions between viral proteins and plant gene products, both in planta and in various in vitro or in vivo systems. These methods and some of the discoveries made using these approaches are discussed.
Spectroanalysis in native gels (SING): rapid spectral analysis of pigmented thylakoid membrane complexes separated by CN–PAGE (2017)

Photosynthetic organisms rapidly adjust the capture, transfer and utilization of light energy to optimize the efficiency of photosynthesis and avoid photodamage. These adjustments involve fine-tuning of expression levels and mutual interactions among electron/proton transfer components and their associated light-harvesting antenna. Detailed studies of these interactions and their dynamics have been hindered by the low throughput and resolution of currently available research tools, which involve laborious isolation, separation and characterization steps. To address these issues, we developed an approach that measured multiple spectroscopic properties of thylakoid preparations directly in native polyacrylamide gel electrophoresis gels, enabling unprecedented resolution of photosynthetic complexes, both in terms of the spectroscopic and functional details, as well as the ability to distinguish separate complexes and thus test their functional connections. As a demonstration, we explore the thylakoid membrane components of Chlamydomonas reinhardtii acclimated to high and low light, using a combination of room temperature absorption and 77K fluorescence emission to generate a multi-dimensional molecular and spectroscopic map of the photosynthetic apparatus. We show that low-light-acclimated cells accumulate a photosystem I-containing megacomplex that is absent in high-light-acclimated cells and contains distinct LhcII proteins that can be distinguished based on their spectral signatures.
Supporting data for Predicting future laboratory fault friction through deep learning transformer models (2022)

This repository contains data for the accompanying paper "Predicting future laboratory fault friction through deep learning transformer models" published in Geophysical Research Letters.
Phase I Pilot Study of the Effects of Trovafloxacin (CP‐99,219) on the Pharmacokinetics of Theophylline in Healthy Men (1997)

This study examined the effect of trovafloxacin (CP-99,219) on the pharmacokinetics and pharmacodynamics of a single dose of theophylline, when administered to steady-state concentrations. Twelve healthy, nonsmoking male volunteers participated. A 450-mg dose of theophylline was administered at 7:00 AM on day 1. On day 4, volunteers received 300 mg of trovafloxacin (CP-99,219) daily in the morning for 7 days. The 450-mg dose of theophylline was repeated on day 8 at 7:00 AM concomitantly with 300 mg of trovafloxacin. Theophylline concentrations in plasma and trovafloxacin in serum were determined using reverse-phase high-performance liquid chromatography. There was no significant difference between the geometric mean values for Cmax of theophylline, 6.42 micrograms/mL and 6.00 micrograms mL on days 1 and 8, respectively. A change (P = 0.032) in the geometric mean of the area under the concentration-time curve extrapolated to infinity (AUC0-infinity) for theophylline was noted for trovafloxacin was administered. Mean terminal phase elimination rate constants (Kes) were reduced (P = 0.001) by 13% after administration of trovafloxacin from day 1 to day 8. In general, changes in theophylline clearance of less than 20% are unlikely to be of clinical significance. In this study, oral administration of trovafloxacin in 300 mg doses to achieve steady-state concentration resulted in an 8.4% increase in the extent of systemic exposure (AUC0-infinity) to theophylline. Assuming that this AUC change is based on oral clearance and not absorption, one would not expect to see clinically significant changes in the pharmacokinetics of theophylline. No pharmacodynamic changes resulted from the pharmacokinetic changes of theophylline.