gebhart/patrepeval huggingface dataset:
Sensitivity to insulin of glycolysis and glycogen synthesis of isolated soleus-muscle strips from sedentary, exercised and exercise-trained rats (1983)

The half-maximal stimulation of the rates of glycolysis and glycogen synthesis in soleus-muscle strips from sedentary animals occurred at a concentration of insulin of about 100 microunits/ml. In soleus-muscle strips from exercise-trained rats (5 weeks of treadmill training), half-maximal stimulation of the rate of glycolysis occurred at about 10 microunits of insulin/ml, whereas that for glycogen synthesis occurred between 10 and 100 microunits of insulin/ml. The sensitivity of glycolysis to insulin after exercise training is similar to that of adipose tissue from sedentary animals. This finding suggests that, in sedentary animals, the effects of normal changes in insulin concentration may affect muscle primarily indirectly via the anti-lipolytic effect on adipose tissue, whereas after training insulin may effect the rate of glycolysis in muscle directly. A single period of exercise did not change the sensitivity of glycolysis in soleus muscle to insulin, nor probably that of glycogen synthesis. It is suggested that the improvement in insulin sensitivity of glycolysis in muscle caused by exercise-training could account, in part, for the well-established improvement in glucose tolerance and insulin sensitivity observed in man and rats after exercise-training.
A fine-grain architecture for relational database aggregation operations (1991)

The design and simulation of a bit-sliced processor for relational database aggregation functions, are discussed. The processor, which addresses an important, computationally expensive problem in database computers, takes two tuples as input (one bit at a time) and returns two bits as output every clock cycle. A larger aggregation unit uses a number of identical slice processors, connected according to odd-even network topology, to achieve improved performance on a parallel pipelined processor. The data processing time is completely overlapped with the input and output of data to and from the unit. The design is independent of the tuple size, and since a bit-serial computation is used, the system requires limited interconnection.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Stabilization of Formate Dehydrogenase in a Metal–Organic Framework for Bioelectrocatalytic Reduction of CO2 (2019)

Abstract The efficient fixation of excess CO 2 from the atmosphere to yield value‐added chemicals remains crucial in response to the increasing levels of carbon emission. Coupling enzymatic reactions with electrochemical regeneration of cofactors is a promising technique for fixing CO 2 , while producing biomass which can be further transformed into biofuels. Herein, a bioelectrocatalytic system was established by depositing crystallites of a mesoporous metal–organic framework (MOF), termed NU‐1006, containing formate dehydrogenase, on a fluorine‐doped tin oxide glass electrode modified with Cp*Rh(2,2′‐bipyridyl‐5,5′‐dicarboxylic acid)Cl 2 complex. This system converts CO 2 into formic acid at a rate of 79±3.4 m m h −1 with electrochemical regeneration of the nicotinamide adenine dinucleotide cofactor. The MOF–enzyme composite exhibited significantly higher catalyst stability when subjected to non‐native conditions compared to the free enzyme, doubling the formic acid yield.
Evaluation of Rice Tissue Culture Lines for Resistance to the Rice Water Weevil (Coleoptera: Curculionidae) (1994)

Journal Article Evaluation of Rice Tissue Culture Lines for Resistance to the Rice Water Weevil (Coleoptera: Curculionidae) Get access F. K. N’guessan, F. K. N’guessan Department of Entomology, Louisiana Agricultural Experiment Station, Louisiana State University Agricultural Center, Baton Rouge, LA 70803 Search for other works by this author on: Oxford Academic PubMed Google Scholar S. S. Quisenberry, S. S. Quisenberry Department of Entomology, Louisiana Agricultural Experiment Station, Louisiana State University Agricultural Center, Baton Rouge, LA 70803 Search for other works by this author on: Oxford Academic PubMed Google Scholar T. P. Croughan T. P. Croughan Department of Entomology, Louisiana Agricultural Experiment Station, Louisiana State University Agricultural Center, Baton Rouge, LA 70803 Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Economic Entomology, Volume 87, Issue 2, 1 April 1994, Pages 504–513, https://doi.org/10.1093/jee/87.2.504 Published: 01 April 1994 Article history Received: 02 June 1993 Accepted: 28 October 1993 Published: 01 April 1994
Determining the Site of Spin Trapping of the Equine Myoglobin Radical by Combined Use of EPR, Electrophoretic Purification, and Mass Spectrometry (2002)

Although myoglobin protein radicals are thought important intermediates in peroxide-induced toxicity, the site of spin trapping of this radical in equine myoglobin using the trap 3,5-dibromo-4-nitrosobenzene sulfonate (DBNBS) is unclear. We have combined EPR, electrophoretic adduct purification, and mass spectrometry approaches to unambiguously determine the site of trapping to be Tyr-103 and suggest that reports of trapping at Trp-7 or Trp-14 may be due to nonradical addition to proteolytically derived Trp-containing peptides with DBNBS. The technique developed here of combining electrophoretic separation of DBNBS adducts with MS of resultant peptides will also allow proteomic-like approaches to determining identities and sites of radical formation and translocation on complex mixtures of proteins.
ChemInform Abstract: Recent Advances in Noble‐Gas Chemistry (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Polynomial Chaos-Based Adaptive Control for Nonlinear Systems (2018)

In this work we present a nonlinear adaptive suboptimal control strategy for uncertain nonlinear systems. Stochastic parametric uncertainty is dealt with by employing spectral decomposition of the random variables by means of the generalized polynomial chaos expansion. The projection of uncertainty onto the orthogonal polynomial basis, prescribed by the Wiener-Askey scheme, provides a deterministic model from which the control laws are designed. We apply the nonlinear feedback control law to an automatic pilot system for recovering an aircraft with uncertain aerodynamic data from stall while providing acceptable dynamic response. The control law is obtained by approximating the Hamilton-Jacobi-Bellman equation by a pertubational procedure and asymptotic weak stability in probability of the controlled nonlinear system is verified in a deterministic way.
Acoustic phonon scattering in Bi2Te3/Sb2Te3 superlattices (2010)

Ultrafast time-resolved measurements were conducted to investigate long-wavelength acoustic phonon scattering and velocity reduction in Bi2Te3/Sb2Te3 superlattices. We show that both these phenomena suppress heat transfer process, with the phonon scattering contributing more in differentiating the lattice thermal conductivities among films with different periods. Measurements of reduction in the acoustic phonon amplitudes support the decrease in the thermal conductivity for certain superlattice periods, which is not predicted by acoustic mismatch theory. This study is a direct measurement of coherent acoustic phonons in superlattices which is of significant interest to thermoelectrics.
Genome Sequence of the Plant Endophyte Bacillus pumilus INR7, Triggering Induced Systemic Resistance in Field Crops (2014)

Bacillus pumilus INR7 is an endophytic bacterium that has been commercialized as a biological control product against soilborne pathogens as well as foliar pathogens by direct antagonism and induction of systemic resistance. In the current study, we provide the genome sequence and a possible explanation of the function of strain INR7.
Final Report for DE-SC0008059 (2017)

Graphene, a one-atom thick material comprising hexagonally bonded carbon atoms, is one of the strongest materials known and is impermeable to even helium gas. The potential for creation of tunable nanometer-scale pores in graphene, combined with mechanical strength, chemical resistance, and atomic thickness, make it a promising material for improving selectivity, permeability, and energy efficiency in a diverse range of membrane separations. However, fundamental understanding of creation of porous graphene, its mass transport properties, and the relationship between porosity and membrane performance is lacking. This project studied methods to create pores in graphene by ion irradiation and etching, and investigated the effect of the porosity of graphene on mass transport properties at the membrane level as well as across individual pores. Detailed characterization of pore size distributions in graphene using high-resolution scanning transmission electron microscopy was performed to elucidate the relationship between different pore creation processes and the resulting porosity. New methods to create tunable nanometer-scale pores in graphene at high density over large areas were developed. Graphene membranes were fabricated comprising single-layer porous graphene on appropriate support membranes. Mass transport of ions, molecules, water, and gases across the membranes was investigated, and predictive models were developed to relate the graphene porosity and support membrane structure to the mass transport properties of the membranes. The effect of graphene porosity on permeance of the membranes to water, salts, and small molecules was experimentally quantified. Single-pore measurements were performed and a model was developed to understand ion transport across graphene pores, which led to the experimental observation of heterogeneity in transport behaviors and spontaneous fluctuations of ion transport. Functional single-layer nanoporous graphene membranes comprising a high density of pores over macro-scale areas with molecular selectivity were demonstrated for the first time. This project led to three patent applications and 9 journal articles. The fundamental developments in understanding nanoporous graphene membranes have laid the foundations to develop energy-efficient nanoporous graphene membranes for various applications in water desalination, oil and natural gas separations, biotechnology, and chemical processing.
Transcriptional regulation of apolipoprotein A-IV by the transcription factor CREBH (2014)

cAMP responsive element-binding protein H (CREBH) is an endoplasmic reticulum (ER) anchored transcription factor that is highly expressed in the liver and small intestine and implicated in nutrient metabolism and proinflammatory response. ApoA-IV is a glycoprotein secreted primarily by the intestine and to a lesser degree by the liver. ApoA-IV expression is suppressed in CREBH-deficient mice and strongly induced by enforced expression of the constitutively active form of CREBH, indicating that CREBH is the major transcription factor regulating Apoa4 gene expression. Here, we show that CREBH directly controls Apoa4 expression through two tandem CREBH binding sites (5'-CCACGTTG-3') located on the promoter, which are conserved between human and mouse. Chromatin immunoprecipitation and electrophoretic mobility-shift assays demonstrated specific association of CREBH with the CREBH binding sites. We also demonstrated that a substantial amount of CREBH protein was basally processed to the active nuclear form in normal mouse liver, which was further increased in steatosis induced by high-fat diet or fasting, increasing apoA-IV expression. However, we failed to find significant activation of CREBH in response to ER stress, arguing against the critical role of CREBH in ER stress response.
Relapsing yersinia infection. (1990)

BrMedJ \990;300:\694 Infection with Yersinia enterocolitica usually results in a benign and self limiting enteric illness with or without mesenteric lymphadenopathy.1 Diagnosis is made by direct culture of yersinia from stools, and in immuno competent adults there is said to be a rapid and measurable serological response.2 If necessary the illness can usually be cured by treatment with tetra cyclines, co-trimoxazole, or trimethoprim.3 The case that we report did not conform to this pattern.
Current Strategic Thinking for the Development of a Trivalent Alphavirus Vaccine for Human Use (2014)

Vaccinations against the encephalitic alphaviruses (western, eastern, and Venezuelan equine encephalitis virus) are of significant interest to biological defense, public health, and agricultural communities alike. Although vaccines licensed for veterinary applications are used in the Western Hemisphere and attenuated or inactivated viruses have been used under Investigational New Drug status to protect at-risk personnel, there are currently no licensed vaccines for use in humans. Here, we will discuss the need for a trivalent vaccine that can protect humans against all three viruses, recent progress to such a vaccine, and a strategy to continue development to Food and Drug Administration licensure.
The Cool Stuff in Premiere Pro (2017)

Gain in-depth knowledge of Premiere Pro, and learn how the software âthinks.â You'll acquire new skills that will help you choose the best workflow for your project, and simplify and accelerate your video editing process.Â Learn how you can edit a lot faster with smarter workflows that automate several steps in the editing process. You'll also see how custom settings, presets, keyboard shortcuts and templates saves hours of work. By tailoring the software to your needs you save clicks on just about every task. With many traditional jobs now being done by one person, its important to understand audio smoothing, color grading, motion graphics, and advanced editing techniques. Youâll learn these skills and disciplines and see how they'll enhance your project's workflow.Â All the authors are professional editors and want to know exactly how to cut your film as fast as possible with top quality output. There is invaluable information inÂ .
Observations of 14 young open star clusters with the HEGRA system of Cherenkov telescopes (2006)

Context. A sample of 14 young open star clusters has been observed in the TeV energy regime with the stereoscopic system of the HEGRA (High Energy Gamma-Ray Astronomy) Cherenkov telescopes from 1997 to 2002, resulting in more than 300 h of observation time.
c-Src is activated by the epidermal growth factor receptor in a pathway that mediates JNK and ERK activation by gonadotropin-releasing hormone in COS7 cells. (2017)

This article has been withdrawn by the authors. Lanes 1–4 and lanes 7–10 of the G-JNK immunoblot in Fig. 1B were duplicated. In Fig. 2A, the DP-JNK immunoblots on the left were inappropriately manipulated. In Fig. 2A, the G-JNK immunoblots in the middle row were duplicated. In Fig. 3B, lanes 2 and 7 of the phosphorylated MBP panel were duplicated. In Fig. 5A, lane 1 of the Ras-GTP panel was inappropriately manipulated. Lanes 7 and 11 were duplicated. Because the original data are no longer available, in the interest of maintaining accuracy in the published scientific literature, the authors wish to withdraw this article. However, the authors have full confidence in the findings and conclusions of this paper.
Gender-Specific Changes in Bone Turnover and Skeletal Architecture in Igfbp-2-Null Mice (2008)

IGF-binding protein-2 (IGFBP-2) is a 36-kDa protein that binds to the IGFs with high affinity. To determine its role in bone turnover, we compared Igfbp2(-/-) mice with Igfbp2(+/+) colony controls. Igfbp2(-/-) males had shorter femurs and were heavier than controls but were not insulin resistant. Serum IGF-I levels in Igfbp2(-/-) mice were 10% higher than Igfbp2(+/+) controls at 8 wk of age; in males, this was accompanied by a 3-fold increase in hepatic Igfbp3 and Igfbp5 mRNA transcripts compared with Igfbp2(+/+) controls. The skeletal phenotype of the Igfbp2(-/-) mice was gender and compartment specific; Igfbp2(-/-) females had increased cortical thickness with a greater periosteal circumference compared with controls, whereas male Igfbp2(-/-) males had reduced cortical bone area and a 20% reduction in the trabecular bone volume fraction due to thinner trabeculae than Igfbp2(+/+) controls. Serum osteocalcin levels were reduced by nearly 40% in Igfbp2(-/-) males, and in vitro, both CFU-ALP(+) preosteoblasts, and tartrate-resistant acid phosphatase-positive osteoclasts were significantly less abundant than in Igfbp2(+/+) male mice. Histomorphometry confirmed fewer osteoblasts and osteoclasts per bone perimeter and reduced bone formation in the Igfbp2(-/-) males. Lysates from both osteoblasts and osteoclasts in the Igfbp2(-/-) males had phosphatase and tensin homolog (PTEN) levels that were significantly higher than Igfbp2(+/+) controls and were suppressed by addition of exogenous IGFBP-2. In summary, there are gender- and compartment-specific changes in Igfbp2(-/-) mice. IGFBP-2 may regulate bone turnover in both an IGF-I-dependent and -independent manner.
Desmin and CD31 immunolabeling for detecting venous invasion of the pancreatobiliary tract cancers (2020)

Although venous invasion (VI) is a poor prognostic factor for patients with pancreatobiliary tract cancers, its histopathologic characteristics have not been well described. We evaluated the patterns of VI and the added benefit provided by CD31, desmin, and dual CD31‒desmin immunolabeling for identification of VI. We included 120 surgically resected pancreatobiliary tract cancer cases-59 cases as a test set with known VI and 61 cases as a validation set without information of VI. VI was classified into three patterns: intraepithelial neoplasia-like (IN-like), conventional, and destructive. Hematoxylin and eosin (H&E) staining and CD31, desmin, and dual CD31‒desmin immunolabeling were performed. Foci number and patterns of VI were compared with the test and validation sets. More foci of VI were detected by single CD31 (P = 0.022) than H&E staining in the test set. CD31 immunolabeling detected more foci of the conventional pattern of VI, and desmin immunolabeling detected more foci of the destructive pattern (all, P < 0.001). Dual CD31‒desmin immunolabeling identified more foci of VI (P = 0.012) and specifically detected more foci of IN-like (P = 0.045) and destructive patterns (P < 0.001) than H&E staining in the validation set. However, dual CD31‒desmin immunolabeling was not helpful for detecting the conventional pattern of VI in the validation set. Patients with VI detected by dual CD31‒desmin immunolabeling had shorter disease-free survival (P <0.001) than those without VI. VI detected by dual CD31‒desmin immunolabeling was a worse prognostic indicator (P = 0.009). More foci of VI could be detected with additional single CD31 or dual CD31‒desmin immunolabeling. The precise evaluation of VI with dual CD31‒desmin immunolabeling can provide additional prognostic information for patients with surgically resected pancreatobiliary tract cancers.
ChemInform Abstract: Cycloaddition of 2H‐Pyran‐2‐thiones with Nitroso Derivatives. An Unexpected Cycloaddition‐Rearrangement Reaction. (1986)

Abstract The title reaction [(II) + (V)] unexpectedly does not yield the corresponding Diels ‐ Alder adducts [cf . (VII)] but the rearranged products (IV).
Classification of digital modulations using constellation analyses (2017)

Skeletal muscle mass is not affected by chronic HCV infection in patients without cirrhosis and decreases in accordance with liver disease progression in male patients with chronic HCV infection.
Silver-Gelatine Metal-Dielectric Composites Made From Developed X-Ray Films (2011)

The artificial dielectric properties of developed silver-gelatine X-ray film have been evaluated at microwave frequencies. The density of the silver particles in the thin films on the surface of the plastic substrate determines the real and imaginary parts of the complex permittivity. The resulting metamaterial was evaluated between 5 and 20 GHz using the split-post dielectric resonator technique. The real part of the relative permittivity of silver-gelatine mixtures varies in the range 4–170 depending on the concentration of silver. The dielectric loss tangent for such materials is in the range 0.06–0.25 and is largest for the highest permittivity samples .
Silencing of tissue factor pathway inhibitor‐2 gene in malignant melanomas (2007)

To identify tumor-suppressor genes inactivated by aberrant methylation of promoter CpG islands (CGIs) in human malignant melanomas, genes upregulated by treatment of cells with a demethylating agent, 5-aza-2'-deoxycytidine (5-aza-dC), were searched for using oligonucleotide microarrays in melanoma cell lines, HMV-I, MeWo and WM-115. Seventy-nine known genes with CGIs were identified as being upregulated (>or=16-fold), and 18 of them had methylation of their putative promoter CGIs in 1 or more of 8 melanoma cell lines. Among the 18 genes, TFPI-2, which is involved in repression of the invasive potential of malignant melanomas, was further analyzed. Its expression was repressed in a melanoma cell line with its complete methylation, and was restored by 5-aza-dC treatment. It was unmethylated in cultured neonatal normal epidermal melanocyte, and was induced by ultraviolet B. In surgical melanoma specimens, TFPI-2 methylation was detected in 5 of 17 metastatic site specimens (29%), while it was not detected in 20 primary site specimens (0%) (p=0.009). By immunohistochemistry, the 5 specimens with promoter methylation lacked immunoreactivity for TFPI-2. The results showed that TFPI-2 is silenced in human malignant melanomas by methylation of its promoter CGI and suggested that its silencing is involved in melanoma metastasis.
Electrical Stimulation Elicits Neural Stem Cells Activation: New Perspectives in CNS Repair (2015)

Researchers are enthusiastically concerned about neural stem cell (NSC) therapy in a wide array of diseases, including stroke, neurodegenerative disease, spinal cord injury, and depression. Although enormous evidences have demonstrated that neurobehavioral improvement may benefit from NSC-supporting regeneration in animal models, approaches to endogenous and transplanted NSCs are blocked by hurdles of migration, proliferation, maturation, and integration of NSCs. Electrical stimulation (ES) may be a selective non-drug approach for mobilizing NSCs in the central nervous system. This technique is suitable for clinical application, because it is well established and its potential complications are manageable. Here, we provide a comprehensive review of the emerging positive role of different electrical cues in regulating NSC biology in vitro and in vivo, as well as biomaterial-based and chemical stimulation of NSCs. In the future, ES combined with stem cell therapy or other cues probably becomes an approach for promoting brain repair.
Stable and Functional Rhomboid Proteases in Lipid Nanodiscs by Using Diisobutylene/Maleic Acid Copolymers (2018)

Rhomboid proteases form a paradigm for intramembrane proteolysis and have been implicated in several human diseases. However, their study is hampered by difficulties in solubilization and purification. We here report on the use of polymers composed of maleic acid and either diisobutylene or styrene for solubilization of rhomboid proteases in lipid nanodiscs, which proceeds with up to 48% efficiency. We show that the activity of rhomboids in lipid nanodiscs is closer to that in the native membrane than rhomboids in detergent. Moreover, a rhomboid that was proteolytically unstable in detergent turned out to be stable in lipid nanodiscs, underlining the benefit of using these polymer-stabilized nanodiscs. The systems are also compatible with the use of activity-based probes and can be used for small molecule inhibitor screening, allowing several downstream applications.