gebhart/patrepeval huggingface dataset:
Two-marker protein profile predicts poor prognosis in patients with early rectal cancer (2008)

The aim of this study was to establish an immunohistochemical protein profile to complement preoperative staging and identify rectal cancer patients at high-risk of adverse outcome. Immunohistochemistry was performed on a tissue microarray including 482 rectal cancers for APAF-1, EphB2, MST1, Ki67, p53, RHAMM, RKIP and CD8(+) tumour infiltrating lymphocytes (TILs). After resampling of the data and multivariable analysis, the most reproducible markers were combined and prognosis evaluated as stratified by pT and pN status. In multivariable analysis, only positive RHAMM (P<0.001; HR=1.94 (1.44-2.61)) and loss of CD8(+) TILs (P=0.006; HR=0.63 (0.45-0.88)) were independent prognostic factors. The 5-year cancer-specific survival rate for RHAMM+/TIL- patients was 30% (95% CI 21-40%) compared to 76% (95% CI: 66-84%) for RHAMM-/TIL+ patients (P<0.001). The 5-year cancer-specific survival of T1/T2/RHAMM+/TIL- patients was 48% (20-72%) and significantly worse compared to T3/T4/RHAMM-/TIL+ patients (71% 95% CI 56-82%); P=0.039). Stratifying by nodal status, only N+/RHAMM+/TIL- patients demonstrated a significantly worse prognosis than N0/RHAMM+/TIL- patients (P=0.005). Loss of CD8(+) TILs was predictive of local recurrence in RHAMM+ tumours (P=0.009) only. RHAMM and CD8(+) TILs may assist in identifying early stage rectal cancer patients facing a particularly poor prognosis and who may derive a benefit from preoperative therapy.
FPGA-Based Adaptive Task Scheduler for Real Time Embedded Systems (2018)

Present invention provides FPGA based Adaptive Scheduler for Real Time System. In the proposed scheme of implementing concurrent architecture for scheduling different task, two concurrent scheduling is observed through round robin technique and the prioritized services are executed. The implementation of the architecture using Field Programmable Gate Array greatly optimizes the constraints like Power, Time, Area and Hardware Resource Utilization and etc. It is proven for development of Efficient and Secured Templates. To demonstrate the performance of the system, traffic light system is implemented considering emergency traffic handling, density based traffic handling and routine traffic handling. At the inside of the system the concurrent status of the service requests raised by different task and from different directions, internal flag register is maintained which indicates the status of the service requests. Based on the status of the internal flag register, service to the request and time allocation is decided adaptively and intelligently. The said architecture has wide applications in Encryption, Decryption, Image Processing, Signal Processing, Secured Wireless Sensor Network, Cloud Computing, Error Correction and Detection Modules and etc. To prove robustness of the architecture, system is first logically tested using Modelsim Simulator and then implemented using variants of Field Programmable Gate Arrays of Xilinx.
Influence of the expectation of a particular signal duration on detectability (1994)

The results of two experiments demonstrated that the detectability of an auditory signal depends on the subject’s expectation about its duration. The signal (a 250-, 1000-, or 4000-Hz tone, or a broadband noise) had one of six durations between 5 and 295 ms. The masker was a continuous, broadband noise (N0=25 dB). Each 2IFC interval was always marked by a fixed-duration visual display whose onset coincided with the onset of all potential signals. When the signal duration was fixed, each signal was correctly detected on about 85% of the trials. in experiment 1, the six subjects were encouraged to expect a particular signal duration (5 or 295 ms) by presenting the signal most often at that duration, and only occasionally at each of the five remaining unexpected durations. Performance for the unexpected signals decreased from 85% to chance as their durations departed from the expected duration. In experiment 2, the signal was randomly presented at each of the six durations with equal probability, and the subjects were so informed. The mean percent correct value was about 79%, with the longest signals being affected the most by the duration uncertainty. The results are analyzed using signal-detection models incorporating the idea of an adjustable temporal-integration window. [Work supported by NIH.]
Control of phosphofructokinase by fructose 2,6-bisphosphate in B-lymphocytes and B-chronic lymphocytic leukemia cells. (1987)

The levels of fructose 2,6-bisphosphate and glucose 1,6-bisphosphate and the activities of the key glycolytic enzymes have been studied in T- and B-lymphocytes, and in B-chronic lymphocytic leukemia cells (B-CLL). In both kinds of cells these two bisphosphorylated metabolites have been identified and are present at similar concentrations. Their phosphofructokinase, like that of other normal or tumoral cells, is sensitive to these activators. Fructose 2,6-bisphosphate is the most potent stimulator; it displays the properties of a positive effector. It greatly increases the affinity for fructose 6-phosphate and relieves the inhibition by adenosine triphosphate, without changing Vmax. This effect is also synergistic with adenosine monophosphate. Despite few differences in the activity of phosphofructokinase and in the content of its main effectors in B-lymphocytes and in B-CLL cells, the kinetic properties of the enzyme from B-CLL cells were different, the enzyme being more sensitive to fructose 2,6-bisphosphate (Ka 2 orders of magnitude lower) and to glucose 1,6-bisphosphate than the enzyme from normal lymphocytes. The results reported showing that phosphofructokinase from B-CLL lymphocytes is altered in regulatory properties and the observed changes, in comparison to phosphofructokinase from normal B-lymphocytes, fit well with the hypothesis that fructose 2,6-bisphosphate can also assume a regulatory role in these cancer cells characterized by proliferation and accumulation of relatively mature-appearing lymphocytes.
Hormonal regulation of CYP1A expression (2009)

Aryl hydrocarbon receptor (AhR) is primarily involved in the transcriptional regulation of CYP1A enzymes, which are the main catalysts of the metabolic activation or inactivation of numerous procarcinogens, carcinogens, environmental toxicants, or therapeutic agents. Several endogenous factors, including hormones, can modify CYP1A induction, directly influencing CYP1A gene expression or AhR function or indirectly via crosstalks with other transcription factors. In this article, we summarize the current knowledge about the role of hormones (i.e., glucocorticoids, estrogens, progesterone, androgens, insulin, and glucagon) and hormone receptors as well as other essential factors (e.g., vitamin D, retinoids) in the modulation of CYP1A expression.
A Peroxiredoxin Promotes H2O2 Signaling and Oxidative Stress Resistance by Oxidizing a Thioredoxin Family Protein (2013)

H2O2 can cause oxidative damage associated with age-related diseases such as diabetes and cancer but is also used to initiate diverse responses, including increased antioxidant gene expression. Despite significant interest, H2O2-signaling mechanisms remain poorly understood. Here, we present a mechanism for the propagation of an H2O2 signal that is vital for the adaptation of the model yeast, Schizosaccharomyces pombe, to oxidative stress. Peroxiredoxins are abundant peroxidases with conserved antiaging and anticancer activities. Remarkably, we find that the only essential function for the thioredoxin peroxidase activity of the Prx Tpx1(hPrx1/2) in resistance to H2O2 is to inhibit a conserved thioredoxin family protein Txl1(hTxnl1/TRP32). Thioredoxins regulate many enzymes and signaling proteins. Thus, our discovery that a Prx amplifies an H2O2 signal by driving the oxidation of a thioredoxin-like protein has important implications, both for Prx function in oxidative stress resistance and for responses to H2O2.
Conformational Entropy (2016)

The document gives definitions of terms met in the conventional thermal and thermomechanical characterisation of polymeric materials.
The Measurement of lumped parameter impedance : (1974)

The measurement of two-terminal impedance in the 30 kHz to 300 MHz range involves a variety of different methods including null, resonance, active and comparison.
Usefulness of a Comprehensive PCR-Based Assay for Human Herpes Viral DNA in Blood Mononuclear Cell Samples (2005)

Human herpes virus (HHV) is well known to reactivate in immunocompromised situations and plays an immunomodulatory role leading to indirect effects through viral replication to the host. The aim of this study was to determine the laboratory and clinical relevance of a comprehensive PCR-based assay for detecting eight HHVs, which are lymphotropic and cause disease in humans. Using 176 samples collected from 146 specimens of peripheral blood, 12 skin nodules, 11 lymph nodes and 7 others of patients who were suspected to have adult T cell leukemia (ATL), the PCR-based assay was validated to simultaneously detect one or more herpes viral DNA with two consensus primer sets. Although most samples were seropositive for either of the HHVs, only 50% of them were positive for either herpes viral DNA with EBV in 76%, HHV-6 in 14% and VZV in 9%. Furthermore, such a herpes viral DNA positive status was not always associated with clinical symptoms relating to the virus, implying active replication in the blood cells, but being asymptomatic. HHV-8 viral DNA, although Kaposi's sarcoma has been reported to be complicated with ATL, was not demonstrable. HHV-6B was detected only in HTLV-1 healthy carriers and ATL patients, and may imply a co-factor role with HTLV-1. This PCR-based assay provides a herpes viral infectious status compensatory for virus-serology and is a clinically relevant laboratory test, serving as a screening marker for active infection.
A cell-based probabilistic approach unveils the concerted action of miRNAs (2018)

Summary Mature microRNAs (miRNAs) regulate most human genes through direct base-pairing with mRNAs. We investigate some underlying principles of such regulation. To this end, we overexpressed miRNAs in different cell types and measured the mRNA decay rate under transcriptional arrest. Parameters extracted from these experiments were incorporated into a computational stochastic framework which was developed to simulate the cooperative action of miRNAs in living cells. We identified gene sets that exhibit coordinated behavior with respect to all major miRNAs, over a broad range of overexpression levels. While a small set of genes is highly sensitive to miRNA manipulations, about 180 genes are insensitive to miRNA manipulations as measured by their degree of mRNA retention. The insensitive genes are associated with the translation machinery. We conclude that the stochastic nature of miRNAs reveals an unexpected robustness of gene expression in living cells. Moreover, the use of a systematic probabilistic approach exposes design principles of cells’ states and in particular, the translational machinery. Highlights A probabilistic-based simulator assesses the cellular response to thousands of miRNA overexpression manipulations The translational machinery displays an exceptional resistance to manipulations of miRNAs. The insensitivity of the translation machinery to miRNA manipulations is shared by different cell types The composition of the most abundant miRNAs dominates cell identity
Computational imaging using a mode-mixing cavity at microwave frequencies (2015)

We present a 3D computational imaging system based on a mode-mixing cavity at microwave frequencies. The core component of this system is an electrically large rectangular cavity with one corner re-shaped to catalyze mode mixing, often called a Sinai Billiard. The front side of the cavity is perforated with a grid of periodic apertures that sample the cavity modes and project them into the imaging scene. The radiated fields are scattered by the scene and are measured by low gain probe antennas. The complex radiation patterns generated by the cavity thus encode the scene information onto a set of frequency modes. Assuming the first Born approximation for scattering dynamics, the received signal is processed using computational methods to reconstruct a 3D image of the scene with resolution determined by the diffraction limit. The proposed mode-mixing cavity is simple to fabricate, exhibits low losses, and can generate highly diverse measurement modes. The imaging system demonstrated in this letter can find application in security screening and medical diagnostic imaging.
Identification and fault diagnosis of nonlinear dynamic processes using hybrid models (2002)

This work addresses a novel approach for fault diagnosis of industrial processes using hybrid models. A nonlinear dynamic process can, in fact, be described as a composition of different affine sub-models selected according to the process operating conditions. This paper deals with the identification of hybrid model parameters through input-output data affected by additive noise. The fault detection scheme adopted to generate residuals uses the estimated hybrid model. In order to show the effectiveness of the developed technique, the results obtained in the fault diagnosis of a real industrial plant are reported.
High Efficiency Source for Metal Ions (1965)

An ion source is described which produces beams of ions of both high and low vapor pressure materials. The source has the following characteristics which make it suitable for accelerator applications or laboratory ion beam experiments where the large size and complexity of isotope separator ion sources would be a disadvantage: (1) small size, (2) simplicity of construction and operation, (3) long filament life, (4) high charge utilization efficiency, (5) wide operating temperature range, (6) relatively modest power requirement, (7) ability to operate efficiently on either gas or solids. The source operates by electron bombardment ionization of the vapor of the charge material. The vapor is obtained by heating the charge to a sufficiently high temperature to achieve the proper source operating pressure. A unique feature of this source is the combination of the discharge chamber and charge container into one chamber. The operating temperature range of the source is from approximately 300 to about 1600°C. Beams of Zn+, Al+, Cu+, Ag+, Au+, and Fe+ ions have been produced which contain but a small percentage of impurity ions. The charge material in all these cases has been the pure metal.
Natural history of nephropathy in type I diabetes. Relationship to metabolic control and blood pressure. (1985)

In recent years, the respective roles of metabolic control and blood pressure on the development of nephropathy in patients with type I diabetes have been studied intensively. Based on our own retrospective analysis, we conclude that metabolic control, but not blood pressure, determines the onset of proteinuria in these patients. Once proteinuria has developed, concurrent metabolic control has little effect on the time interval to onset of renal failure. In contrast, blood pressure has great predictive value for the time interval to onset of both renal failure and proliferative retinopathy.
The Difficulty of Proving Electrochemical Ammonia Synthesis (2019)

ADVERTISEMENT RETURN TO ISSUEPREVViewpointNEXTThe Difficulty of Proving Electrochemical Ammonia SynthesisJakob Kibsgaard*Jakob KibsgaardDepartment of Physics, Technical University of Denmark, 2800-DK Kgs. Lyngby, Denmark*E-mail: [email protected] (J.K.).More by Jakob Kibsgaardhttp://orcid.org/0000-0002-9219-816X, Jens K. Nørskov*Jens K. NørskovDepartment of Physics, Technical University of Denmark, 2800-DK Kgs. Lyngby, Denmark*E-mail: [email protected] (J.K.N.).More by Jens K. Nørskov, and Ib Chorkendorff*Ib ChorkendorffDepartment of Physics, Technical University of Denmark, 2800-DK Kgs. Lyngby, Denmark*E-mail: [email protected] (I.C.)More by Ib Chorkendorffhttp://orcid.org/0000-0003-2738-0325Cite this: ACS Energy Lett. 2019, 4, 12, 2986–2988Publication Date (Web):November 19, 2019Publication History Received18 October 2019Accepted18 November 2019Published online19 November 2019Published inissue 13 December 2019https://pubs.acs.org/doi/10.1021/acsenergylett.9b02286https://doi.org/10.1021/acsenergylett.9b02286article-commentaryACS PublicationsCopyright © 2019 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views10297Altmetric-Citations129LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (672 KB) Get e-AlertscloseSUBJECTS:Ammonia,Electrochemical synthesis,Free energy,Nitrogen,Separation science Get e-Alerts
Ni(COD)(DQ): An Air‐Stable 18‐Electron Nickel(0)–Olefin Precatalyst (2020)

Abstract We report that Ni(COD)(DQ) (COD=1,5‐cyclooctadiene, DQ=duroquinone), an air‐stable 18‐electron complex originally described by Schrauzer in 1962, is a competent precatalyst for a variety of nickel‐catalyzed synthetic methods from the literature. Due to its apparent stability, use of Ni(COD)(DQ) as a precatalyst allows reactions to be conveniently performed without use of an inert‐atmosphere glovebox, as demonstrated across several case studies.
Synthesis of aromatic polyketones by nonstoichiometric Friedel–Crafts polycondensation using AlCl3 (2020)

Aromatic polyketones were successfully synthesized by Friedel–Crafts acylation using AlCl<sub>3</sub> between aromatic dicarboxylic acid chlorides and 2,2′-dimethoxybiphenyl under both stoichiometric and nonstoichiometric conditions.
Tau in Chronic Traumatic Encephalopathy (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Determination of trace pharmaceutical residue indomethacin in water samples by an enzyme-linked immunosorbent assay (2008)

Determination of trace pharmaceutical residue indomethacin in water samples by an enzyme-linked immunosorbent assay was presented.The immunogen was prepared by linking indomethacin with BSA,and high quality polyclonal antibodies were obtained by normal immunization processes.After the optimization of experimental conditions,a highly sensitive,specific,simple and stable ELISA for the determination of pharmaceutical indomethacin in water samples was developed.IC50 value(concentration of analyte producing 50% of absorbance decrease in standard curve) and detection limit was found in the range of 0.09μg/L~0.17μg/L and 0.005μg/L~0.01 μg/L,respectively.Two types of real water samples were collected and analyzed by the developed ELISA.The existence of indomethacin with the concentration ranging 0.016μg/L~0.083μg/L in real water samples was observed,and the recoveries of indomethacin added in real water samples were within 84.4%~127.0%.
In the News (2020)

ACRL will host it 7th National Conference in Pittsburgh.I am ver excited about the programming ACRL is offer ing and in this issue we share with you man of the program highlights.Four nationally known speakers-Jennife
Translational and radial motions of a bubble in an acoustic standing wave field (1993)

The dynamic responses of a spherical bubble in an acoustic standing wave field are studied numerically. The equations of motion in the translational and the radial directions are solved simultaneously. It is shown that a bubble which is larger than the resonance size moves to a node of the pressure field and its radial oscillations become small. A sufficiently small bubble is shown to move to an antinode and radially oscillates under the maximum pressure amplitude. It is found using Poincaré maps and power spectra that a bubble which is slightly smaller than the resonance size oscillates chaotically in both the radial and the translational directions. It is demonstrated that the range of the equilibrium bubble size which shows chaotic motions broadens with the pressure amplitude. Finally, the radial responses of the bubble are shown to be dependent not only on the pressure amplitude but also on the drag force in the translational direction.
The Trial of the Top Gas Recycling Blast Furnace at LKAB's EBF and Scale-up (2009)

The history of the LKAB's Experimental Blast Furnace is briefly reviewed and an introduction to the ULCOS new blast furnace is presented. The feasibility of the scale-up of the ULCOS New Blast Furnace - UNBF based on previous and new trials results at EBF are concisely discussed. The historical trial results of using the EBF to simulate the conventional industrial blast furnace processes indicated that the EBF is able to imitate the commercial blast furnaces of different size and burden structure. The trial results can be directly extrapolated to the commercial furnaces. The discussions regarding the scale-up of the UNBF showed that based on the EBF as well as the trials of the UNBF concept it is completely feasible to determine the dimensions of a full scale furnace and the process parameters for an industrial scale trial of the UNBF concept.