gebhart/patrepeval huggingface dataset:
Gene expression profiling predicts response of rectal adenocarcinomas to neoadjuvant radiochemotherapy (2005)

When preceding surgery, neoadjuvant radiochemotherapy can decrease local recurrence and has become standard treatment modality in specialized surgical centers. However, there is a wide spectrum of tumor responsiveness ranging from complete response to complete resistance. Pre-therapeutic predictors would therefore be of considerable clinical significance for stratification of patients into groups of responders or non-responders of radiochemotherapy. Pre-therapeutic biopsies from 23 locally advanced rectal carcinomas (determined by rectal ultrasound as uT3 and uT4) were analyzed for gene expression signatures using cDNA microarrays. All patients were participants of a phase III clinical trial (CAO/ARO/AIO–94, German Rectal Cancer Trial) and were randomized to receive a neoadjuvant 5-FU based radiochemotherapy. The clinical response has been defined as T-level down-sizing after neoadjuvant radiochemotherapy. A class comparison analysis revealed that responders and non-responders showed significantly different expression levels for 54 genes (p<0.001). Employing Leave-One-Out-Cross-Validation (LOOCV), the expression data allowed prediction of therapy response in 83% of patients (p=0.03). Sensitivity was 89% and specificity was 79% with a positive predictive value of 73% and negative predictive value of 92%. These results suggest that pre-therapeutical gene expression profiling can assist in the prediction of response of rectal carcinomas to radiochemotherapy. It is conceivable that it will be possible to stratify patients into responders or non-responders to 5-FU.
Oral History Interview with Norman Dykes, Lt. C. E. Shaffer, Sgt. Gary Cochran, Officer James Thornton, and Officer Roger Clifford, 1983 (1983)

Interview with Norman Dykes, Lt. C. E. Shaffer, Sgt. Gary Cochran, Officer James Thornton, and Officer Roger Clifford, residents of Baytown, TX during Hurricane Alicia. They discuss their memories of Hurricane Alicia.
Host cell transcriptomic response to the multidrug-resistant Mycobacterium tuberculosis clonal outbreak Beijing strain reveals its pathogenic features (2022)

The upsurge of multidrug-resistant infections has rendered tuberculosis the principal cause of death among infectious diseases. A clonal outbreak multidrug-resistant triggering strain of <i>Mycobacterium tuberculosis</i> was identified in Kanchanaburi Province, labelled "MKR superspreader," which was found to subsequently spread to other regions, as revealed by prior epidemiological reports in Thailand. Herein, we showed that the MKR displayed a higher growth rate upon infection into host macrophages in comparison with the H37Rv reference strain. To further elucidate MKR's biology, we utilized RNA-Seq and differential gene expression analyses to identify host factors involved in the intracellular viability of the MKR. A set of host genes function in the cellular response to lipid pathway was found to be uniquely up-regulated in host macrophages infected with the MKR, but not those infected with H37Rv. Within this set of genes, the IL-36 cytokines which regulate host cell cholesterol metabolism and resistance against mycobacteria attracted our interest, as our previous study revealed that the MKR elevated genes associated with cholesterol breakdown during its growth inside host macrophages. Indeed, when comparing macrophages infected with the MKR to H37Rv-infected cells, our RNA-Seq data showed that the expression ratio of <i>IL-36RN</i>, the negative regulator of the IL-36 pathway, to that of <i>IL-36G</i> was greater in macrophages infected with the MKR. Furthermore, the MKR's intracellular survival and increased intracellular cholesterol level in the MKR-infected macrophages were diminished with decreased <i>IL-36RN</i> expression. Overall, our results indicated that <i>IL-36RN</i> could serve as a new target against this emerging multidrug-resistant <i>M. tuberculosis</i> strain.
Recovery of aroma compounds from a wine-must fermentation by organophilic pervaporation (1999)

This study investigates the recovery of a wine-must aroma profile, formed by Saccharomyces cerevisiae during a muscatel wine-must fermentation, using organophilic pervaporation. Experiments were carried out along two independent, but organoleptically similar, fermentations. The wine-must samples and the aroma concentrates obtained were characterized organoleptically by a sensory panel and analytically with regard to eight major wine-must components: four alcohols; three esters; and one monoterpenic compound. Pervaporation performance was studied under fermentation conditions, and the permeate concentration, partial fluxes, and enrichment of the respective compounds were determined. The muscatel wine-must aroma profile was recovered purely and faithful to its origin between wine-must densities of 1075 and 1055 g L. At the beginning of the fermentation, too few aromas were present in the must for recovery. Toward the end of the fermentation, high ethanol concentrations in the wine-must caused a dramatic enrichment of two esters in the permeate, whereas other components investigated seemed unaffected. This shift resulted in an unbalanced aroma. In conclusion, it was shown that organophilic pervaporation can be highly suitable for the continuous recovery of very complex and delicate aromatic profiles produced during microbial fermentation. Copyright 1999 John Wiley & Sons, Inc.
SENSORS MEASURE UP TO EMERGING AUTOMOTIVE SAFETY STANDARDS (2000)

Automotive applications are spawning the development of a host of sensor types for use in systems related to rider safety; engine and drive train; comfort, convenience, or security; and vehicle diagnostics or monitoring. Automakers are starting to implement occupancy seat sensors that improve airbag deployment and angular-rate sensors for enhancing vehicle dynamic controls. A detailed discussion of these sensor types is provided in this article. It is pointed out that, given the evolving safety standards, we can expect to see a migration to the more sophisticated sensing schemes.
A dialytic battery with ion-exchange membranes. Dependence of the power output on the concentration of saline water. (1995)

A dialytic battery (DB) with ion-exchange membranes can convert the mixing free energy into the electric energy. The solar membrane cell (SMC) which was proposed by one of the present authors consists of DB and a solar still. The seawater is separated into the fresh water and the concentrated seawater by flowing through the solar still. Therefore, in order to seek a feasibility of SMC it needs to make a performance test of DB at higher concentration than the seawater. In the present study, an experimental study has been made on the concentration dependence of the DB-performance. The dialytic battery constructed consists of 101 compartments and has an effective area of 475cm2 per a sheet of ion-exchange menbrane. The carbon plate electrodes were used, which would produce not only an electric power, but also useful materials such as Cl2-, H2-gas as a result of the electrode reaction. The saline water concentration cc ranged from 3.5-17wt%. The open circuit potential decreased from 9 to 7V with increasing cc. The power output, however, increased considerably with the increase in cc due to the decrease in the internal resistance: The maximum power of about 1100mW was obtained at the concentration of 17wt%. The Weinstein-Leitz model has been modified so as to be applicable to the present case. An good agreement was obtained between the calculated and the measured.
Quantum efficiency measurements for several waveshifter coatings in the extreme vacuum ultraviolet (1984)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Cyrus L. Butner and Walter Viehmann, "Quantum efficiency measurements for several waveshifter coatings in the extreme vacuum ultraviolet," Appl. Opt. 23, 2046-2048 (1984) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
PREDICT OF TIRE / ROAD NOISE FROM ROAD SURFACE PROPERTIES (2002)

If a tire / road contact noise can be predicted from road surface properties, the directivity of an improvement of properties becomes clear and is effective various road surfaces.On this research we examined towards establishment of a tire / road contact noise, and various road surface properties with relation using the indoor examination machine.As a result, it becomes clear that tire / road noise can be predicted from both tire/road contact partial ratio and on-site water permeability.
Host Cell Control of Heterologous Protein Production in Saccharomyces cerevisiae (2020)

A major emphasis of molecular biology research in eukaryotes has been the detailed analysis and characterization of the yeast Saccharomyces cerevisiae. Emphasis on the applied aspects of recombinant DNA technology has prompted the expansion of basic research into a wide variety of yeasts and fungi previously little known outside of specialized industries. Although it is clear that differences exist between the alternative yeasts and S. cerevisiae that necessitate modifications of existing recombinant DNA protocols, the wealth of knowledge gained in the development of S. cerevisiae provides an insight into what one can expect to encounter in the development of transformation and cloning systems in the non-Saccharomyces yeasts. In 1978, Hinnen et al. reported the successful and reproducible transformation of protoplasts of a S. cerevisiae leu strain with a plasmid consisting of the bacterial vector and the s. cerevisiae gene.
ChemInform Abstract: Synthesis and Structure‐Activity Relationship of Some New β‐Blocking Agents with Possible α‐Adrenoreceptor Activity. (1990)

Abstract The nitrophenols (I) are coupled with epichlorohydrin (II) to yield the glycidyl ethers (III) which are cleaved with the amines (IV), forming the amino alcohols (V).
Effects Of Creatine Supplementation On Muscle Efficiency And Indices Of Endurance Performance In Elderly Women (2005)

PURPOSE The purpose of this study was to determine the effects of short-term (7 d) oral creatine supplementation (0.3 g·kg body mass−1) on muscle working efficiency and several other indices associated with sub-maximal endurance performance (e.g., one-mile walk test, ventilatory threshold (VT), or VO2peak) in elderly women. METHODS Subjects were assigned to a creatine (N = 10; 67±6 y) or placebo group (N = 6; 68±4 y) and performed both 1) a ramp cycle-ergometer test for VT and VO2peak determination and 2) a constant-load test (6-min duration) on the same ergometer at the power output eliciting the VT for determination of gross mechanical efficiency (GE). RESULTS A two-way analysis of variance (ANOVA) with repeated measures on time did not show any significant group, time or interaction effect (group × time) for any of the aforementioned variables (Table 1).Table 1: Results (mean±SD) of laboratory exercise testsNo significant group, time or interaction effect was found for the pre- and post-test time performance in the one-mile walk-test ((placebo: 993±79 s vs. 981±86 s; creatine: 929±82 s vs. 896±85 s). CONCLUSIONS In elderly, moderately physically active women, short-term (7 d) oral creatine supplementation does not seem to improve functional capacity during cardiorespiratory related tasks (e.g., no changes in muscle efficiency or other indices of endurance performance ability as the VT). Further research efforts using longer treatment periods and/or higher dosages are suitable to corroborate the present results.
Detecting learning in noisy data (2020)

In a school context, learning is usually detected by repeated measurements of the skill of interest through a sequence of specially designed tests; in particular, this is the case with tracking improvement in oral reading fluency in elementary school children in the U.S. Results presented in this paper suggest that it is possible and feasible to detect improvement in oral reading fluency using data collected during children's independent reading of a book using the Relay Reader™ app. We are thus a step closer to the vision of having a child read for the story, not for a test, yet being able to unobtrusively assess their progress in oral reading fluency.
Equisetum arvense L. (2005)

https://thekeep.eiu.edu/herbarium_specimens_byname/10270/thumbnail.jpg
Ferroelectric liquid crystal materials applied to guest-host type displays (1988)

Abstract Bistable ferroelectric liquid crystals (FLCs) suited for guest-host devices are described. Tilt angles of eight compounds and contrast ratios of the guest-host cells were measured as a function of temperature. The eight compounds were categorized into two classes. The first class exhibited the smectic A (SA) phase with a tilt angle of around 22°. The second class did not show the SA phase; the tilt angle was about 35° and almost constant over the temperature range of the smectic C(SC) phase. It was experimentally confirmed that the guest-host cell for the compound with the large tilt angle of 35° had a higher contrast ratio than 10. By using a binary system consisting of one compound from each class, influence of the tilt angle on bistability was examined. Increasing of the tilt angle improved not only the optical contrast ratio but also bistability.
[Managing conflict in psychiatric institutions]. (1991)

Several observations made by the author in everyday practice during his activity as a supervisor of psychiatric therapy teams, are described. These can be classified as "subcultural phenomena". It is shown how the members of a therapy team will modify certain institutional conditions and parameters unconsciously but purposefully and make use of them for coping with conflict situations. This is demonstrated, inter alia, by the manner in which the duty schedule is handled and how the team deals with the sickness of a team member. This type of conflict management is then placed in relation to two major conflict potentials that come into play during everyday work in a psychiatric hospital: on the one hand, the pathogenic relationship offers made by the mentally ill patients, and on the other hand the adaptation strategies acquired during professional and institutional socialisation and moored in the conscious depths of the team member's soul. These adaptation strategies are interpreted by the team members as components of their professional identity. The therapeutic quality of an institution can thus be measured by the extent to which that institution succeeds in supporting these adaptive elements of its members and hence in relieving them of some of the mental stress to which they are exposed.
The Rotor-Stator Interaction Onboard A Low Specific Speed Francis Turbine (2020)

Over the last years, several breakdowns in hydropower plants with low specific speed Francis runners have been reported. One of the main excitation forces in such runners is the pressure fluctuations originating from the rotor stator interaction. In this paper, the rotor-stator interaction has been analyzed utilizing pressure sensors onboard the runner. The pressure sensors were flush mounted in the hub of the runner and the signals were transmitted through a slip-ring system. The measurements have been analyzed relative to the runner angular position by utilizing an angular position sensor mounted to the shaft end. Measurements with different guide vane angle have been compared in order to study the potential flow interaction and the viscous wake effects for the pressure inside the runner. The results from the onboard pressure measurements found that the phase of the guide vane passing pressure seen by the onboard pressure sensors was independent of the guide vane opening. Hence, the potential flow interaction was found to be the dominant effect and no evidence from the viscous wake effect was found on the onboard pressure.
Coastal Pollution Mitigation with Lime and Zero Valent Iron (2006)

The Taiwan Strait region has many miles of coastline, and the Taiwan Straits Tunnel (TST) project faces many potential pollution problems as construction proceeds through sensitive areas. Conventional approaches for pollution mitigation require further examination. The recent development of nanoscale particle technology has shown distinct advantages for contaminant attenuation and ground improvement. This paper is focused on trace metals and is part of the overall effort to develop the nanoscale particle technology. Trace metals in ground and surface waters represent a continued threat to human and ecological health. One of the difficulties in removing toxic concentrations of trace metals from solution is the variable oxidation state and amphoteric nature of multiple constituents. In particular, while cationic metals (e.g., Pb2+, Cd2+, Ni2+) may be rendered less mobile under high pH conditions, anionic metals (e.g., AsO4 3−, CrO4 2−, SeO4 2−)may become more mobile. The objective of this research was to evaluate the sorption of both cationic and anionic trace elements, including arsenic (As), cadmium (Cd), chromium (Cr) and selenium (Se) under batch conditions. Mixtures of a local residual soil were tested alone and in combination with lime and zero valent iron. It was hypothesized that lime would raise the pH and precipitate positively charged metals while zero valent iron would create reducing conditions favorable to the immobilization of negatively charged metals. Results indicate that the use of lime and/or zero valent iron can increase the sorption capacity of soil. Compared to the baseline soil, sorption capacity increased with addition of lime for arsenic and cadmium while it decreased for chromium and selenium. In the case of zero valent iron addition, sorption capacity increased for cadmium, chromium and selenium, while showing no change for arsenic. When both lime and zero valent iron were used, the sorption capacity increased for all metals tested. These results suggest that the combined use of lime and zero valent iron may serve as an alternative treatment technology for removing trace metals from contaminated water systems.
Retinal Tumor Induced in the Baboon by Human Adenovirus 12 (1980)

Three of 21 newborn baboons injected intraocularly with human adenovirus type 12 developed an intravitreal mass 12 to 36 months later. Two of the masses were indistinguishable from human retinoblastoma, a retinal tumor that afflicts children. To our knowledge this is the first time a retinoblastoma-like tumor has been induced experimentally by adenovirus type 12 in a nonhuman primate.
Advances in the genomics of common eye diseases (2013)

Genome-wide association studies (GWAS) and other genomic technologies have accelerated the discovery of genes and genomic regions contributing to common human ocular disorders with complex inheritance. Age-related macular degeneration (AMD), diabetic retinopathy (DR), glaucoma and myopia account for the majority of visual impairment worldwide. Over 19 genes and/or genomic regions have been associated with AMD. Current investigations are assessing the clinical utility of risk score panels and therapies targeting disease-specific pathways. DR is the leading cause of blindness in the United States and globally is a major cause of vision loss. Genomic investigations have identified molecular pathways associated with DR in animal models which could suggest novel therapeutic targets. Three types of glaucoma, primary-open-angle glaucoma (POAG), angle-closure glaucoma and exfoliation syndrome (XFS) glaucoma, are common age-related conditions. Five genomic regions have been associated with POAG, three with angle-closure glaucoma and one with XFS. Myopia causes substantial ocular morbidity throughout the world. Recent large GWAS have identified >20 associated loci for this condition. In this report, we present a comprehensive overview of the genes and genomic regions contributing to disease susceptibility for these common blinding ocular disorders and discuss the next steps toward translation to effective gene-based screening tests and novel therapies targeting the molecular events contributing to disease.
Improving regulation of a single-link flexible manipulator with strain feedback (1998)

This paper considers improving the tip regulation performance of a joint-PD controlled single-link flexible manipulator by introducing nonlinear strain feedback. The controller is developed by applying Lyapunov's direct method. The stability of the closed-loop system is theoretically proven based on the partial differential equations (PDE) which govern the motion of the flexible robot, instead of using the traditional truncated models. The controller is very simple in its form, and only the measurements of joint angle, joint velocity, and strain of the bending beam are needed for implementation. The controller is very robust as well because it is independent of system parameters.
An In Vivo Rat Model to Investigate Female Vaginal Arousal Response (2004)

Our data suggest that the rat is a useful and reliable animal model for investigating the vaginal arousal response. In addition, we used this model to demonstrate the important role of the NO-cyclic guanosine monophosphate pathway in vaginal arousal.
Interference Caused by Additional Radio Channels using Nonsinusoidal Carriers (1977)

The first radio transmitters and receivers using nonsinusoidal carriers have been built during the last few years. Most advanced Is the Into-the-ground radar by Chapman, which has become commercially available for construction surveys. Many other good applications for nonsinusoidal waves are known, primarily In radar but also for special types of communications. These waves share the spectrum with the existing radio services that have been traditionally separated by the use of different frequency bands. Two questions arise from the standpoint of frequency management: 1. Can we provide additional radio channels by the use of nonsinusoidal carriers? 2. How will such carriers affect existing radio services? The answer to the first question is that it is indeed possible to add channels to the existing ones, and not merely replace radio channels based on sinusoidal carriers. The existing radio services will be affected, in first approximation, as if the natural background noise had increased.
Effect of (3‐glycidyloxypropyl)trimethoxysilane (GOPS) on the electrical properties of PEDOT:PSS films (2017)

Poly(3,4‐ethylenedioxythiophene) doped with poly(styrenesulfonate) (PEDOT:PSS) has been reported as a successful functional material in a broad variety of applications. One of the most important advantages of PEDOT:PSS is its water‐solubility, which enables simple and environmental friendly manufacturing processes. Unfortunately, this also implies that pristine PEDOT:PSS films are unsuitable for applications in aqueous environments. To reach stability in polar solvents, (3‐glycidyloxypropyl)trimethoxysilane (GOPS) is typically used to cross‐link PEDOT:PSS. Although this strategy is widely used, its mechanism and effect on PEDOT:PSS performance have not been articulated yet. Here, we present a broad study that provides a better understanding of the effect of GOPS on the electrical and electronic properties of PEDOT:PSS. We show that the GOPS reacts with the sulfonic acid group of the excess PSS, causing a change in the PEDOT:PSS film morphology, while the oxidation level of PEDOT remains unaffected. This is at the origin of the observed conductivity changes. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2017, 55, 814–820