gebhart/patrepeval huggingface dataset:
Sesquiterpenoid Lactones in Tanacetum huronense Inhibit Human Glioblastoma Cell Proliferation (2016)

Tanacetum huronense (Lake Huron tansy), which is native to the upper Midwest region of USA and Canada, was examined for the presence of anticancer compounds using an in vitro human tumor cell proliferation inhibition assay, with glioblastoma derived cell line U-87 MG. Bioassay-directed purification of the ethyl acetate extract of the aerial portion of this plant identified six active sesquiterpenoid lactones (1-6). Among these, compounds 5 and 6 are new structural analogs. One of the most abundant isolates, tanacin (4), exhibited the greatest inhibition with an IC50 value of 4.5 μg/mL.
Transparent Amorphous Oxide Semiconductors (2022)

Since 2012, thin-film transistors (TFTs) based on amorphous oxide semiconductors (AOSs) for their channel layers have been commercialized as active components in the back-plane circuits of active-matrix flat-panel displays (AM-FPDs) from wearable small devices to wall-sized televisions. Applications of the AOS-TFTs start to develop from AM-FPDs to other essential devices such as memories and very-large-scale integrated circuits. Though oxide semiconductor–based TFTs were first demonstrated in 1962, active research and development for industrial applications have started since amorphous indium-gallium-zinc-oxide (a-IGZO) TFTs were successfully invented in 2004. In this chapter, the reason for the rapid commercialization and spread of AOS-TFTs in only eight years is discussed in relation to the unique features of AOS-TFTs and their timely matching to the industrial requirements of modern electronic devices.
Final state interaction and \Delta I=1/2 rule (2007)

Contrary to wide-spread opinion that the final state interaction (FSI) enhances the amplitude <2\pi;I=0|K^0>, we argue that FSI does not increase the absolute value of this amplitude.
Development of the radiation sensitivity of PMOS dosimeters (1992)

The effect of gate oxide growth conditions on the sensitivity of the NMRC's PMOS RADFET, which has a 400-nm dry/wet/dry gate oxide is investigated. The necessity for such an evaluation arose because the PMOS RADFET standard gate oxide consists of a dry/wet/dry 400-nm oxide, and published data for the effects of processing conditions on gate oxides are mainly for either wet or dry oxides with a thickness in the more conventional gate oxide range of 20 nm-100 nm. It is clearly shown that, for any given RADFET gate oxide, an optimum set of processing conditions exists to maximize the RADFET's radiation sensitivity. A by-product of the evaluation of the processing conditions is that it is possible to set up a sensitivity-oxide thickness curve at the optimum processing conditions.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Cordycepin Inhibits Induction of Murine Leukovirus Production By 5-Iodo-2′-deoxyuridine (1972)

Cordycepin (3'-deoxyadenosine), an inhibitor of poly(A) synthesis during the processing of nuclear heterogenous RNA, blocks the production of RNA viruses induced by 5-iodo-2'-deoxyuridine in BALB/3T3 and BALB/K-3T3 cells. This inhibitory activity is not a result of either nonspecific cell killing or general cytotoxicity by cordycepin; rather, it appears to be specific, because cordycepin acts only at a critical time to inhibit virus production. These findings, together with the finding of poly(A) sequences in viral RNAs, suggest that RNA tumor viruses replicate via a transcription of proviral DNA.
Atomically thin boron nitride: a tunnelling barrier for graphene devices (2012)

We investigate the electronic properties of heterostructures based on ultrathin hexagonal boron nitride (h-BN) crystalline layers sandwiched between two layers of graphene as well as other conducting materials (graphite, gold). The tunnel conductance depends exponentially on the number of h-BN atomic layers, down to a monolayer thickness. Exponential behaviour of I-V characteristics for graphene/BN/graphene and graphite/BN/graphite devices is determined mainly by the changes in the density of states with bias voltage in the electrodes. Conductive atomic force microscopy scans across h-BN terraces of different thickness reveal a high level of uniformity in the tunnel current. Our results demonstrate that atomically thin h-BN acts as a defect-free dielectric with a high breakdown field; it offers great potential for applications in tunnel devices and in field-effect transistors with a high carrier density in the conducting channel.
Photoluminescence and electroluminescence characteristics of CaSiN 2 :Eu phosphor (1997)

Photoluminescence and electroluminescence of CaSiN 2 :Eu materials were investigated to develop a new phosphor for thin film electroluminescence (TFEL) device applications. Ca 3 N 2 and Si 3 N 4 powders were mixed to form CaSiN 2 host materials and Eu was added as the luminescent center. The mixed powder materials were cold pressed under the pressure of 1Kg/cm 2 to make pellets, and fired at 1400°C for 2 hours under N 2 /H 2 environment. The X-ray diffraction (XRD) patterns of synthesized materials were well matched with CaSiN 2 of joint committee for powder diffraction standards (JCPDS) card. When illuminated by ultraviolet rays, the new phosphors emitted very bright red light of peak wavelength centered at 620 nm. The TFEL devices with CaSiN 2 :Eu phosphor layers were grown by sputter deposition of CaSiN 2 :Eu target. Red light emission was observed when the peak amplitude of the applied voltage exceeded 116V. The luminance was shown to increase sharply with the increase of the applied voltage. The maximum luminance was 1.62 Cd/m 2 at the applied peak voltage of 276V. The red emission from CaSiN 2 :Eu TFEL device seems to result from electronic transition of Eu 3+ ions. The emission spectra of TFEL devices match well with the photoluminescence spectra of CaSiN 2 :Eu powders. The new devices structure and fabrication processes for the improvement of emission intensity of CaSiN 2 :Eu TFEL devices are under investigation.
Legal Education and Professional Development - an Educational Continuum, Report of the Task Force on Law Schools and the Profession: Narrowing the Gap, (Illinois: American Bar Association 1992) (1993)

This American Bar Association (ABA) Task Force publication is a report of the findings of an in-depth study of the “range of skills and values necessary for a lawyer to assume responsibility for handling a legal matter.”The ABA Task Force which prepared the Report was comprised of approximately 40 leading law academics, legal practitioners and members of the judiciary. The project took three years to complete and is commendable for its thoroughness and the manner in which it built upon the foundation laid by earlier studies such as Zemans and Rosenblum, The Making of a Public Profession. The purpose of this review article is twofold: first, to summarise the findings of this ABA Task Force Report which was released in November 1992; and second, to consider what implications this US study may hold for Australian Legal Education which is facing, or in the future will face, many of the same issues.
Quantitative Protein Corona Composition and Dynamics on Carbon Nanotubes in Biological Environments (2020)

When nanoparticles enter biological environments, proteins adsorb to form the "protein corona" which alters nanoparticle biodistribution and toxicity. Herein, we measure protein corona formation on DNA-functionalized single-walled carbon nanotubes (ssDNA-SWCNTs), a nanoparticle used widely for sensing and delivery, in blood plasma and cerebrospinal fluid. We characterize corona composition by mass spectrometry, revealing high-abundance corona proteins involved in lipid binding, complement activation, and coagulation. We investigate roles of electrostatic and entropic interactions driving selective corona formation. Lastly, we study real-time protein binding on ssDNA-SWCNTs, obtaining agreement between enriched proteins binding strongly and depleted proteins binding marginally, while highlighting cooperative adsorption mechanisms. Knowledge of protein corona composition, formation mechanisms, and dynamics informs nanoparticle translation from in vitro design to in vivo application.
Multiple ADF-STEM Towards the Optimization of Electron Tomography Reconstructions of Pt/C fuel cell catalyst nanostructures (2021)

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Combined Dynamic Power- and QoS-Management in Embedded Video Surveillance Systems (2004)

The method is applicable for the broad range of patient sizes, comfortable for patients, robust and suitable for standard treatment rooms with a standard linear accelerator. It requires minimal investments into equipment.
Multichannel Nonlocal Means Fusion for Color Image Denoising (2013)

In this paper, we propose an advanced color image denoising scheme called multichannel nonlocal means fusion (MNLF), where noise reduction is formulated as the minimization of a penalty function. An inherent feature of color images is the strong interchannel correlation, which is introduced into the penalty function as additional prior constraints to expect a better performance. The optimal solution of the minimization problem is derived, consisting of constructing and fusing multiple nonlocal means (NLM) spanning all three channels. The weights in the fusion are optimized to minimize the overall mean squared denoising error, with the help of the extended and adapted Stein's unbiased risk estimator (SURE). Simulations on representative test images under various noise levels verify the improvement brought by the multichannel NLM, compared to the traditional single-channel NLM. In the meantime, MNLF provides competitive performance both in terms of the color peak signal-to-noise ratio and in perceptual quality when compared with other state-of-the-art benchmarks.
Randomized phase II trial of capecitabine (X) versus X plus erlotinib (E) in patients (pts) with metastatic colorectal cancer (mCRC): Differential impact of KRAS. (2011)

e14031^ Background: Palliative X monotherapy of mCRC is generally tolerated by elderly, and/or medically unfit pts. Epidermal growth factor receptor (EGFR) inhibitors improve efficacy when added to combination chemotherapy for mCRC. It is unknown whether biologic agents add benefit to alone in pts who either opt against, or are not candidate for, combination chemotherapy. We conducted a randomized phase II trial to investigate the novel “all-oral” combination of low-dose X and E in this pt population. Methods: Eligible pts with mCRC were either deemed unfit for, or chose against, 1st-line combination chemotherapy. Pts were randomized to X (1000 mg/m2 PO BID x 14 days) alone or in combination with E (150 mg PO OD) on a 3-week schedule. A 3rd arm (E alone) was ineffective, and discontinued after a preplanned interim analysis. Imaging was performed every 9 weeks until progression. Primary endpoint was time to disease progression (TTP); secondary endpoints included: objective response rate (ORR), overall survival (OS), safety and quality of life. Results: From June 2004 to June 2008, 95 pts [median age: 67; range 40-84; ECOG PS: 0 (45pts), 1 (38 pts), or 2 (22 pts)] were randomized to X alone (40 pts), XE (42 pts), or E alone (13 pts). KRAS status, where possible, was analyzed for pts in the first 2 arms only. As compared to X alone, XE was associated with significantly more Gr 3+ toxicity: (diarrhea: 29% vs 5%; fatigue: 12% vs 0%; anorexia 7% vs 0%; stomatitis 7% vs 0%). One pt discontinued treatment in the X arm vs 2 in XE. There was 1 toxic death in XE. TTP was not different for the whole trial (X=7.9 m, XE=9.2 m; p=0.8897), but exploratory subgroup differences emerged (below). Conclusions: The addition of E to X is associated with additional toxicity. E may benefit pts with KRAS-wild-type CRC and may harm those with KRAS-mutated CRC. Further study of XE in elderly/unfit pts with KRAS-wild-type CRC is warranted. Supported by grant from Roche. Median TTP (m) X XE p All pts (n = 40 / 42) 7.9 9.2 0.8897 KRAS wt (n =18 / 24) 8.4 11.7 * KRAS mut (n = 18 / 12) 7.4 1.9 * *Cox regression p=0.0236 for interaction of study arm by Kras status.
Preparation and solid state-structure of a 1,3,5-triazine-bridged tris(1,2,3,5-dithiadiazolyl) complex [N3C3(CN2S2)3] (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and solid state-structure of a 1,3,5-triazine-bridged tris(1,2,3,5-dithiadiazolyl) complex [N3C3(CN2S2)3]A. W. Cordes, R. C. Haddon, R. G. Hicks, D. K. Kennepohl, R. T. Oakley, L. F. Schneemeyer, and J. V. WaszczakCite this: Inorg. Chem. 1993, 32, 9, 1554–1558Publication Date (Print):April 1, 1993Publication History Published online1 May 2002Published inissue 1 April 1993https://pubs.acs.org/doi/10.1021/ic00061a007https://doi.org/10.1021/ic00061a007research-articleACS PublicationsRequest reuse permissionsArticle Views217Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Classification of Peritumoral Fiber Tract Alterations in Gliomas Using Metabolic and Structural Neuroimaging (2011)

Our multimodal neuroimaging approach provides complementary information and more detailed understanding of peritumoral fiber tract alterations in gliomas which are more complex as described so far. We presented a classification model for systematic assessment of these alterations that may be helpful for treatment planning and prediction of patients' prognoses.
Social Connectedness on Facebook - An Explorative Study on Status Message Usage (2010)

With over 400 million active users Facebook is undeniably a large social phenomenon and one of the largest social networks on the Internet. Together with Facebook a variety of novel communication styles have developed, dramatically influencing social interaction. The underlying paper reports the results of a survey (N=109) analyzing Facebook’s micro-blogging function available through users’ status updates. Our results suggest that the use of status update messaging generates a feeling of connectedness between users. Furthermore, non-parametric analyses distinguishing between low- and highconnected groups have been performed and experimentally confirmed the existence of distinct user profiles as a function of the variable “feeling connected”. The analyses revealed that the more individuals use their status message function to actively reveal information about themselves, the more connected they feel. Connectedness seems the result of active information sharing modulated by the amount of information shared rather than by the type of information an individual is sharing.
Determination of the promoter strength in the mixed transcription system, II. Promoters of ribosomal RNA, ribosomal protein S1 andrecAprotein operons fromEscherichia coli (1983)

Using the in vitro mixed transcription system (Kajitani, M. and Ishihama, A. (1983) Nucleic Acids Res. 11, 671-686), we determined the two parameters of the promoter strength, i.e., the rate of open complex formation between RNA polymerase and promoter, and the saturation level of the open complex formation at equilibrium, for the promoters of ribosomal RNA (rrnE), ribosomal protein S1 (rpsA) and recA protein (recA) operons from Escherichia coli. Taken together with the previous determinations for lactose (lac(UV5)), tryptophan (trp) and ribosomal protein L10 (rp1J) operons, these studies revealed that the relative promoter strengths with respect to the kinetic parameter are 200, 70, 50, 40, 30, 20 and 2% of the reference promoter lacP(UV5) for recAp, rp1Jp, rpsAp3, trpP, rpsAp1, rrnEp1 and rrnEp2, respectively, under our standard reaction conditions (50 mM NaCl and 37 degrees C); and those with respect to the thermodynamic parameter are 70, 35, 20, 10, 10, 10 and 5% the level of lacP(UV5) for rrnEp2, trpP, rpsAp3, rp1Jp, rpsAp1, rrnEp1 and recAp, respectively. The order of the promoter strength, however, changes with variation of the salt concentration or reaction temperature.
The Beginning of Pharmacovigilance in Bosnia and Herzegovina (2020)

Aims: The aims of this article are to present the impact of the pharmacovigilance performance improvement in Bosnia and Herzegovina on the reporting results gathered at the national pharmacovigilance database. Subjects and methods: Bosnia and Herzegovina is a country in Europe with a complicated political structure, the highest rate of unemployment and a low Gross Domestic Product. Although the Agency for Medicinal Products and Medical Devices of Bosnia and Herzegovina was established in 2009, with the Main Office for Pharmacovigilance as the national pharmacovigilance center, there were no activities and work in the field of pharmacovigilance. In 2017 several changes were made in the work of the Main Office such as: employment of an external expert for the work of pharmacovigilance, holding lectures and workshops, collecting and analyzing adverse drug reactions, signing various co-operations with professional chambers and health institutions forwarding reports to the World Health Organization and writing annual reports. Results: These changes showed an increase in the collected adverse drug reactions by 130% and 28% on an annual level for 2017 and 2018, respectively. Bosnia and Herzegovina became a full member of the Uppsala Monitoring Center, a global office for drug monitoring by the World Health Organization. Conclusion: Bosnia and Herzegovina can be used as an example for developing a sustainable pharmacovigilance system in countries with low economical standards.
Maternally transferred anti‐factor VIII IgG reduce the anti‐factor VIII humoral immune response in factor VIII‐deficient mice (2010)

Replacement therapy with exogenous factor VIII (FVIII) to treat haemorrhages or used in prophylaxis induces inhibitory anti-FVIII immunoglobulin G (IgG) in some patients with haemophilia A. Therapeutic strategies to prevent the onset of the deleterious anti-FVIII immune response are still lacking. Maternal IgG is transferred to the offspring during fetal and neonatal life. While protecting the offspring from bacterial and viral infections, maternal IgG may alter the repertoires of T and B lymphocytes, and may impair vaccination in early infancy. Using haemophilic mice, we demonstrate that the transfer of maternal anti-FVIII IgG modulates the onset of anti-FVIII inhibitory IgG in early adulthood. The protective effect is reproduced upon reconstitution of naive mice with anti-FVIII IgG, suggesting that the reduced ability to mount an anti-FVIII immune response is the result of an interference between circulating anti-FVIII IgG and the administered FVIII rather than to a profound remodelling of lymphocyte repertoires occurring during the ontogeny of the immune system.
Electronic and Optical Properties in the Solid‐State Molecular Assemblies of Anion‐Responsive Pyrrole‐Based π‐Conjugated Systems (2010)

On the basis of the chemistry in solution, the solid-state structures and the corresponding electronic and optical properties of dipyrrolyldiketone boron complexes as π-conjugated acyclic anion receptors have been investigated. Solid-state assemblies of the receptors exhibit anion-dependent properties that are in sharp contrast to those in the solution state. Anion complexation, along with structural differences in the pyrrole subunits such as a benzo-fused pyrrole, plays an essential role not only in the formation of the assembled modes but also in determining electronic and optical properties, as well as the charge-carrier mobilities. In addition, by anion complexation, inclusion of the counter cations into the crystals has also been found to be one of the essential factors to determine the properties.
Embedded protocol processor for fast and efficient packet reception (2003)

Computer network equipment presents a bottleneck for further increasing the capacity in the networks. Terminals have problems keeping up with network speed when using general purpose processors for protocol processing. We present a novel processor architecture, that works in-line with the data flow and does not use a traditional von Neuman architecture. The program is contained in three lookup tables within the processor core, which allows for one cycle if-then-else and switch-case-case... execution. The processor is estimated to be able to handle a 10 Gb/s Ethernet connection when implemented in 0.18 micron technology.
Evidence for rice Heading date 16 contribution to yield increase under low-nutrient conditions (2019)

Breeding new rice cultivars that are tolerant to low-nutrient condition is a solution to saving the usage of commercial fertilizer. We isolated Hitomebore EMS mutant, 520-6. Seedling growth of 520-6 is tolerant to low-nutrient supply, especially to low phosphorus (low P) supply and genetic mapping revealed the existence of nonsynonymous substitution within Os03g0793500 9th exon in 520-6. Os03g0793500 is reported as Heading date 16 (Hd16)/Early flowering1 (EL1), which is related with the rice flowering pathway. Hd16/EL1 encodes a casein kinase-I protein, and phosphorylates the floral repressor Ghd7 and the rice DELLA protein Slender rice 1 (SLR1). 520-6 carries the same nonfunctional Hd16 allele to that of Koshihikari, and the parental cultivar, Hitomebore, carries the functional Hd16 allele, as with Nipponbare. mRNA accumulation of GA-biosynthesis-related gene, OsGA2ox3 was enhanced in 520-6 compared with Hitomebore, indicating that Hd16 takes a part in feedback regulation of the GA biosynthetic gene. 520-6 and near-isogenic line (NIL) with nonfunctional Hd16 allele showed heavy straw weight and panicle weight in paddy fields with low nitrogen input and no fertilizer application in Kashimadai at Miyagi prefecture and Hikone at Shiga prefecture, respectively. In addition, plants with nonfunctional Hd16 allele showed late flowering phenotype in all tested fields. These results imply that disruption of Hd16 contributes to the improvement of rice growth by positively regulating GA signaling and late flowering, which resulted in increased rice yield under low-nutrient conditions.