gebhart/patrepeval huggingface dataset:
The Role of Host Cholesterol During Flavivirus Infection (2018)

In recent years the emergence and resurgence of arboviruses have generated a global health alert. Among arboviruses, Dengue (DENV), Zika (ZIKV), Yellow Fever (YFV), and West Nile (WNV) virus, belong to the genus <i>Flavivirus</i>, cause high viremia and occasionally fatal clinical disease in humans. Given the genetic austerity of the virus, they depend on cellular factors and organelles to complete its replication. One of the cellular components required for flavivirus infection is cholesterol. Cholesterol is an abundant lipid in biomembranes of eukaryotes cells and is necessary to maintain the cellular homeostasis. Recently, it has been reported, that cholesterol is fundamental during flavivirus infection in both mammal and insect vector models. During infection with DENV, ZIKV, YFV, and WNV the modulation of levels of host-cholesterol facilitates viral entry, replicative complexes formation, assembly, egress, and control of the interferon type I response. This modulation involves changes in cholesterol uptake with the concomitant regulation of cholesterol receptors as well as changes in cholesterol synthesis related to important modifications in cellular metabolism pathways. In view of the flavivirus dependence of cholesterol and the lack of an effective anti-flaviviral treatment, this cellular lipid has been proposed as a therapeutic target to treat infection using FDA-approved cholesterol-lowering drugs. This review aims to address the dependence of cholesterol by flaviviruses as well as the basis for anti flaviviral therapy using drugs which target is cholesterol synthesis or uptake.
Synthesis of metal–organic frameworks by continuous flow (2014)

MIL-53(Al) can be prepared <italic>via</italic> reaction in continuous flow in only 5–6 minutes with a space time yield of 1300 kg m<sup>−3</sup> d<sup>−1</sup>. Extraction of free terephthalic acid from within the pores of MIL-53(Al) using supercritical ethanol has been developed.
W. J. Ong, Orality and Literacy. The Technologizing of the Word (1983)

Boyer Pascal. W. J. Ong, Orality and Literacy. The Technologizing of the Word. In: L'Homme, 1983, tome 23 n°2. pp. 118-119.
Dynamic Grouped Chip-Level Iterated Multiuser Detection Based on Gaussian Forcing Technique (2008)

The brute-force MAP-based chip-level iterated (CLi) multiuser detection techniques exploiting the newly proposed low-density signature (LDS) structure have been shown to approach the performance of single-user even at overloading condition of up to 200%. However, their complexity is exponential to the number of interfering users in a chip that can be impractical. In this letter, by using Gaussian-forcing (GF) technique, we trade-off performance and complexity and it results in a dynamic grouped GF (G-GF) CLi MUD technique. We show via computer simulation, at the system with 200% condition, the loss of approximately 0.3 dB compared to its brute-force counterpart is observed while reducing the complexity to more than half.
Data for: Chemotaxonomic evaluation of different species into Myrtaceae family by UPLC-MS coupled to chemometrics (2020)

Dataset Myrtaceae: It was possible to characterize 217 organic compounds in leaves from 15 species into the Myrtaceae family (considering the repeated compounds among them). The tables summarize the characterized compounds into four genders according to their m/z values and fragmentation profiles: Plinia – Tables S1 and S2; Psidium – Tables S3-6; Myrciaria – Tables S7 and S8; and Eugenia – Tables S9-15). Myrtaceae Matrix: LC-MS spreadsheet for retention time x intensity for each species.
Age, gender, corneal diameter, corneal curvature and central corneal thickness in Nigerians with normal intra ocular pressure (2012)

To investigate the relationship between age, gender, corneal diameter, central corneal curvature, central corneal thickness (CCT) and intraocular pressure in Nigerians with normal intraocular pressure. One hundred and thirty eyes from 130 subjects (mean age = 47.8 ± 16.8 years) including 77 males and 53 females were recruited. CCT was measured by ultrasound pachymetry, intraocular pressure was determined by non-contact tonometry, horizontal and vertical corneal diameters were measured with a ruler and central corneal curvature was measured by keratometry. The mean values obtained were as follows: CCT = 548.97 ± 34.28 μm, IOP = 15.61 ± 2.69 mmHg, average corneal curvature (AVK) = 42.98 ± 1.19 D, horizontal corneal diameter (HVID) = 11.39 ± 0.69 mm and vertical corneal diameter (VVID) = 10.51 ± 0.50 mm. There was a significant effect of age on CCT (r = −0.35, p < 0.001). A 10-year-increase in age was associated with a 7.0 μm decrease in CCT. Males had significantly wider HVID than females (p = 0.03). Subjects in older age groups have narrower HVID and VVID. Corneal curvature, corneal diameter and gender did not significantly affect CCT. CCT of normotensive Nigerian adults decreases with increasing age. There was no correlation between CCT and IOP in normotensive subjects. CCT was not significantly influenced by gender, corneal curvature and corneal diameter. investigar la relación entre la edad, el sexo, el diámetro corneal, la curvatura corneal central, el espesor corneal central (ECC) y la presión intraocular en nigerianos con presión intraocular normal. se incluyeron 130 ojos derechos de 130 sujetos (media de edad = 47,8 ± 16,8 años), de los cuales 77 eran hombres y 53 mujeres. Se midió el ECC por paquimetría ultrasónica, la presión intraocular se determinó mediante tonometría sin contacto, el diámetro corneal vertical y horizontal se midió con una regla milimétrica y la curvatura corneal central se determinó por queratometría. los valores medios obtenidos fueron los siguientes: ECC = 548,97 ± 34,28 μm; PIO = 15,61 ± 2,69 mmHg; curvatura corneal media (AVK) = 42,98 ± 1,19 D, diámetro corneal horizontal (HVID) = 11,39 ± 0,69 mm y diámetro corneal vertical (VVID) = 10,51 ± 0,50 mm. Hubo un efecto significativo de la edad sobre el ECC (r = -0,35, p < 0,001). Un aumento de la edad en 10 años se asoció con una disminución del ECC de 7,0 μm. Los hombres presentaron un HVID más amplio que el de las mujeres (p = 0,03). Los sujetos de mayor edad tenían HVID y VVID menores. La curvatura corneal, el diámetro corneal y el sexo no tuvieron un efecto significativo sobre el ECC. el ECC de los adultos nigerianos normotensos disminuye con la edad. No se observó ninguna correlación entre el ECC y la PIO en los sujetos normotensos. El sexo, la curvatura corneal y el diámetro corneal no tuvieron un efecto significativo sobre el ECC.
Identification of a New Toxin in a Strain of Staphylococcus aureus S130 Isolated from a Patient with Nonmenstrual TSS (1989)

The extracellular products of a toxic shock syndrome toxin 1 (TSST-1)-negative isolate of Staphylococcus aureus (strain D4508) from a patient with nonmenstrual toxic shock syndrome were shown to possess toxic activity capable of producing shock and death when injected into rabbits. Fractionation of the extracellular products and the production of polyclonal antibodies to individual polypeptides identified the toxin as a single polypeptide of molecular weight 26,000. Immunoblot analyses showed the toxin to be antigenically related yet distinct from enterotoxins A, B, C, D, and E and unrelated to TSST-1.
A new n-C31:9polyene hydrocarbon from Antarctic bacteria (1995)

The non-saponifiable neutral lipid composition of nineteen bacterial strains isolated from Antarctic sea ice were analysed. Nine of these strains produced a novel highly unsaturated straight chain hydrocarbon as the major non-saponifiable neutral lipid component. The compound was identified as hentriacontanonene (n-C31.9) by mass spectrometry and the formation of n-C31:0 following hydrogenation. The occurrence of n-C31:9 also correlated with the production of polyunsaturated fatty acids (PUFA) by the bacterial strains. n-C31:9 may therefore represent a novel biomarker for the location of PUFA-producing bacteria from environmental samples.
Macular pigment density measured by autofluorescence spectrometry: comparison with reflectometry and heterochromatic flicker photometry (2001)

We present a technique for estimating the density of the human macular pigment noninvasively that takes advantage of the autofluorescence of lipofuscin, which is normally present in the human retinal pigment epithelium. By measuring the intensity of fluorescence at 710 nm, where macular pigment has essentially zero absorption, and stimulating the fluorescence with two wavelengths, one well absorbed by macular pigment and the other minimally absorbed by macular pigment, we can make accurate single-pass measurements of the macular pigment density. We used the technique to measure macular pigment density in a group of 159 subjects with normal retinal status ranging in age between 15 and 80 years. Average macular pigment density was 0.48 +/- 0.16 density unit (D.U.) for a 2 degrees -diameter test field. We show that these estimates are highly correlated with reflectometric (mean: 0.23 +/- 0.07 D.U.) and psychophysical (mean: 0.37 +/- 0.26 D.U.; obtained by heterochromatic flicker photometry) estimates of macular pigment in the same subjects, despite the fact that systematic differences in the estimated density exist between techniques. Repeat measurements over both short- and long-time intervals indicate that the autofluorescence technique is reproducible: The mean absolute difference between estimates was less than 0.05 D.U., superior to the reproducibility obtained by reflectometry and flicker photometry. To understand the systematic differences between density estimates obtained from the different methods, we analyzed the underlying assumptions of each technique. Specifically, we looked at the effect of self-screening by visual pigment, the effect of changes in optical property of the deeper retinal layers, including the role of retinal pigmented epithelium melanin, and the role of secondary fluorophores and reflectors in the anterior layers of the retina.
Investigation of Fertility Preservation Education Videos for Pediatric Patients Based on International and Historical Survey (2023)

<b><i>Purpose:</i></b> Recently, direct communication with children about cancer seems to have shifted, but little is known about communication regarding discussions of future infertility risk due to cancer therapy. This study conducted cross-cultural comparisons between Japan and the United States to clarify communication patterns about cancer notification and develop appropriate information about fertility issues. <b><i>Methods:</i></b> An online survey was distributed to members of the Japanese Society of Pediatric Hematology/Oncology in July 2019 and the American Society of Pediatric Hematology/Oncology in July 2020. Based on the results from the survey, we developed three types of educational videos: a prepubertal version A, B, and a pubertal version. Next, we conducted a survey to assess whether these were appropriate for clinical practice. <b><i>Results:</i></b> We analyzed 325 physicians in Japan and 46 in the United States. In Japan, 80.5%, 91.7%, and 92.1% of the physicians notified patients aged 7-9, 10-14, and 15-17 years of their cancer diagnosis directly, respectively, compared within the United States, where the rate was 100%, regardless of age. Further, 9% and 45% of physicians in Japan and the United States, respectively, discuss fertility issues directly with patients aged 7-9 years. In the survey to assess the educational videos, 85% of the physicians preferred to use the educational videos in clinical practice. <b><i>Conclusion:</i></b> This is the first step in bringing concordance to communication patters for emerging cancer care around the globe and that this study and its intervention arm provide guidance in ways that ensure global equity in care.
Looking to Listen at the Cocktail Party: A Speaker-Independent Audio-Visual Model for Speech Separation (2018)

We present a joint audio-visual model for isolating a single speech signal from a mixture of sounds such as other speakers and background noise. Solving this task using only audio as input is extremely challenging and does not provide an association of the separated speech signals with speakers in the video. In this paper, we present a deep network-based model that incorporates both visual and auditory signals to solve this task. The visual features are used to "focus" the audio on desired speakers in a scene and to improve the speech separation quality. To train our joint audio-visual model, we introduce AVSpeech, a new dataset comprised of thousands of hours of video segments from the Web. We demonstrate the applicability of our method to classic speech separation tasks, as well as real-world scenarios involving heated interviews, noisy bars, and screaming children, only requiring the user to specify the face of the person in the video whose speech they want to isolate. Our method shows clear advantage over state-of-the-art audio-only speech separation in cases of mixed speech. In addition, our model, which is speaker-independent (trained once, applicable to any speaker), produces better results than recent audio-visual speech separation methods that are speaker-dependent (require training a separate model for each speaker of interest).
The influence of environmental effects on excited-state lifetimes. The effect of ion pairing on metal-to-ligand charge transfer excited states (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe influence of environmental effects on excited-state lifetimes. The effect of ion pairing on metal-to-ligand charge transfer excited statesWilliam J. Vining, Jonathan V. Caspar, and Thomas J. MeyerCite this: J. Phys. Chem. 1985, 89, 7, 1095–1099Publication Date (Print):March 1, 1985Publication History Published online1 May 2002Published inissue 1 March 1985https://pubs.acs.org/doi/10.1021/j100253a010https://doi.org/10.1021/j100253a010research-articleACS PublicationsRequest reuse permissionsArticle Views331Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Development of Multi-Compartment 3D-Printed Tablets Loaded with Self-Nanoemulsified Formulations of Various Drugs: A New Strategy for Personalized Medicine (2021)

This work aimed to develop a three-dimensional printed (3DP) tablet containing glimepiride (GLMP) and/or rosuvastatin (RSV) for treatment of dyslipidemia in patients with diabetes. Curcumin oil was extracted from the dried rhizomes of <i>Curcuma longa</i> and utilized to develop a self-nanoemulsifying drug delivery system (SNEDDS). Screening mixture experimental design was conducted to develop SNEDDS formulation with a minimum droplet size. Five different semi-solid pastes were prepared and rheologically characterized. The prepared pastes were used to develop 3DP tablets using extrusion printing. The quality attributes of the 3DP tablets were evaluated. A non-compartmental extravascular pharmacokinetic model was implemented to investigate the in vivo behavior of the prepared tablets and the studied marketed products. The optimized SNEDDS, of a 94.43 ± 3.55 nm droplet size, was found to contain 15%, 75%, and 10% of oil, polyethylene glycol 400, and tween 80, respectively. The prepared pastes revealed a shear-thinning of pseudoplastic flow behavior. Flat-faced round tablets of 15 mm diameter and 5.6-11.2 mm thickness were successfully printed and illustrated good criteria for friability, weight variation, and content uniformity. Drug release was superior from SNEDDS-based tablets when compared to non-SNEDDS tablets. Scanning electron microscopy study of the 3DP tablets revealed a semi-porous surface that exhibited some curvature with the appearance of tortuosity and a gel porous-like structure of the inner section. GLMP and RSV demonstrated relative bioavailability of 159.50% and 245.16%, respectively. Accordingly, the developed 3DP tablets could be considered as a promising combined oral drug therapy used in treatment of metabolic disorders. However, clinical studies are needed to investigate their efficacy and safety.
Photoinduced Phase Transitions in Rod-shaped Azobenzene with Different Alkyl Chain Length (2016)

The direct and reversible solid-liquid phase transitions by photochromic reactions at constant temperature are of interest because of potential applications in reusable adhesives, photoresists and so on. We report photoinduced solid-liquid phase transitions in rod-shaped azobenzenes, possessing a methyl group at the 3-position and alkoxy groups with different chain length (Cn = 1-18) at the 4- and 4'-positions. Thermal property, photochemical property, and adhesive properties were investigated. We found that the azobenzenes with alkyl chain length of 6-10 showed relatively fast photoinduced solid-liquid phase transition than that with shorter (Cn = 1-5) and longer (Cn = 11-18) ones. Tensile shear strength were measured by using these azobenzenes as photoresponsive adhesives. Irradiation with UV light (365 nm) induced the phase transition to the liquid phase and the adhesion strength values decreased to almost zero. Then the irradiation with visible light (450 nm) recovered the adhesion strength.
Basic criteria in hygienic design (2018)

49th R3Nordic Symposium - Cleanroom Technology, Contamination Control and Cleaning Proceedings, Gun Wirtanen &amp; Raimo Pärssinen (eds.) ISBN 978-952-216-674-6 (pdf) Reports from Turku University of Applied Sciences 245
Donor‐derived human herpesvirus 8 infection with Kaposi sarcoma and Kaposi sarcoma inflammatory cytokine syndrome in a heart transplant recipient: A case report (2021)

Human herpesvirus-8 (HHV-8) infection is associated with neoplastic and non-neoplastic diseases in immunocompromised patients. Kaposi sarcoma (KS) is a common malignancy reported in solid organ transplant recipients (SOTR). Kaposi sarcoma inflammatory cytokine syndrome (KICS), initially described in HIV patients, is characterized by high viral loads, elevated levels of cytokines, cytopenia, high fever, organ failure, and poor outcome. We report the case of a 54-year-old patient who developed simultaneous occurrence of KS of lymph nodes and KICS as a complication of primary donor-transmitted HHV-8 infection, after heart transplantation (HT). The diagnosis, management, and prognosis of this condition are unclear and needs a multidisciplinary approach.
Acupuncture as a Treatment Modality in Dermatology: A Systematic Review (2015)

Acupuncture improves outcome measures in the treatment of dermatitis, chloasma, pruritus, urticaria, hyperhidrosis, and facial elasticity. Future studies should ideally be double-blinded and standardize the control intervention.
811 User Interface for Remote Control of a Mobile Robot via Internet (2001)

In this paper, a remote operation system of a mobile robot on WWW browsers is constructed based on TCP/IP network techniques. Data of a CCD camera and sonar sensors on a mobile robot is transmitted to a client PC by CGI, Socket of Java API, etc. Real time performance is improved by such efficient transmissions. An user interface is developed to appeal visually to an operator using the drawing ability of Java applets. Additionally, a framework is proposed to display multiple robots on remote site to local WWW browsers.
3-D analysis of biomarkers and investigation of temporal series by Quant3D, a Linux/UNIX software package (2002)

Sumary Fluorescent Laser Scanning Confocal Microscopy (LSCM) and image analysis are the tools of choice to record and virtually manipulate the volumetric information collected by optical sectioning of multilabeled crypts or colonocytes primary culture. Rendering of biomarker distribution and relative quantification according to the tissue geometry have been achieved by writing a user-friendly Linux/ UNIX software (Quant3D). Image stacks are registered by confocal microscopy on 3 channels, Red Green Blue coded and indexed. The depth of 1 micron between two consecutive images was set to consider the 730 nm maximal depth resolution described for fluorescent LSCM (Brakenhoff et al, 1985). We used a Zeiss LSM 410 confocal microscope equipped with 2 lasers. Stacks of multiple labeling were assembled with a public available image analysis software (ImageJ : http://rsb.inf o.nih.gov/ij/) and analyzed with our Linux software, Quant3D, developed by the Biometry Unite of the INRA. We propose a microscopic multidimensional analytic system to provide quantitative recording in primary culture. The system is amenable to semi-automation by allowing a rapid extraction of intensities from image series of crypt cells multilabeled for nuclei, Epidermal Growth Factor-Receptors (EGF-R), gap-junction proteins, mitochondria activities, cells membranes. We have built a new graphical interface of a software developed for visualization and analysis of three dimensional multispectral data. Most of the software relies on two C++ libraries : Qt and Vtk. The tridimensional colorized views are illustrative of the qualitative and quantitative possibilities of this application. Quant3D will be improved to allow graphical and quantitative presentation of data obtained by recording biomarkers useful for chronobiological studies in fluorescent microscopy.
Inflammatory bowel disease mucosal biopsies have specialized lymphokine mRNA profiles (1996)

: Crohn's disease (CD) and ulcerative colitis (UC) are idiopathic inflammatory bowel diseases (IBD) that are characterized by chronic intestinal inflammation and are associated with abnormalities of peripheral and mucosal immune function. The aim of our study was to determine whether CD or UC is characterized by discrete profiles of intestinal lymphokine production. Total cellular RNA was isolated from biopsies of healthy controls and from patients with IBD. Messenger RNA transcript levels in biopsies were determined for interleukin-2 (IL-2), IL-4, IL-5, and interferon-γ (IFN-γ), using a quantitative reverse transcriptase polymerase chain reaction method. Compared with inflamed UC mucosa and controls, CD mucosal lesions contained higher IL-2 and IFN-γ mRNA (p < 0.05), which is consistent with a T-helper cell 1 (Th1)-like pattern. In UC, IL-5 mRNA content was higher in involved areas compared with controls (p < 0.05) and inflamed CD lesions (p < 0.05), suggestive of a Th2 pattern. We conclude that the intestinal mucosa of CD and UC have inflammatory responses characterized by discrete T-helper profiles of lymphokines. This strongly suggests that the immunopathogenesis of these two forms of IBD are different.