gebhart/patrepeval huggingface dataset:
Characterization of the expression of the hypoxia‐induced genes neuritin, TXNIP and IGFBP3 in cancer (2006)

By triggering an adaptive response to hypoxia which is a common feature of tumor microenvironments, endothelial cells contribute to the onset of angiogenic responses involved in tumor growth. Therefore, identifying hypoxic markers represent a challenge for a better understanding of tumor angiogenesis and for the optimization of anti-angiogenic therapeutic strategy. Using representational difference analysis combined with microarray, we here report the identification of 133 hypoxia-induced transcripts in human microendothelial cells (HMEC-1). By Northern blot, we confirm hypoxia-induced expression of insulin-like growth factor binding protein 3 (igfbp3), thioredoxin-interacting protein (txnip), neuritin (nrn1). Finally, by performing in situ hybridization on several types of human tumors, we provide evidence for nrn1 and txnip as hypoxic perinecrotic markers and for igfbp3 as a tumor endothelial marker. We propose these hypoxia-induced genes could represent relevant prognostic tools and targets for therapeutic intervention in cancers.
Electrochemically Driven C−H Hydrogen Abstraction Processes with the Tetrachloro‐Phthalimido‐N‐Oxyl (Cl4PINO) Catalyst (2018)

Abstract The radical redox mediator tetrachloro‐phthalimido‐N‐oxyl (Cl 4 PINO) is generated at a glassy carbon electrode and investigated for the model oxidation of primary and secondary alcohols with particular attention to reaction rates and mechanism. The two‐electron oxidation reactions of a range of primary, secondary, and cyclic alcohols are dissected into an initial step based on C−H hydrogen abstraction (rate constant k 1 , confirmed by kinetic isotope effect) and a fast radical‐radical coupling of the resulting alcohol radical with Cl 4 PINO to give a ketal that only slowly releases the aldehyde/ketone and redox mediator precursor back into solution (rate constant k 2 ). In situ electrochemical EPR reveals Cl 4 PINO sensitivity towards moisture. DFT methods are applied to confirm and predict C−H hydrogen abstraction reactivity.
Tracer Technology for Water-Alternating-Gas Miscible Flooding in Pubei Oil Field (2000)

Abstract There has been an increasing interest in tracer surveillance program to not only make better reservoir characterization, but also to effectively monitor reservoir performance. Both water and gas tracers have been selected for the tracer program in Pubei oil field, the first water-alternating-gas (WAG) miscible flooding project in China, in terms of combining geological characteristic, reservoir engineering scheme and laboratory research. This paper presents that commercial compositional model was successively used to simulate the well-to-well gas tracer and water tracer performance, to quantify the distribution of tagged solvent among the producers, and to estimate swept volumes. A novel approach was used to link the sub-program for water tracer equations of motion. The application result of the model to the field shows that it can be effectively used to modify the reservoir model and to provide important information for effectively adjusting and controlling the reservoir performance as well as optimizing production and injection.
Reactivation of temperature-sensitive and non-temperature-sensitive infectious bovine rhinotracheitis vaccine virus with dexamethasone (1980)

Latent infections by a temperature-sensitive (ts) infectious bovine rhinotracheitis virus vaccines was produced as frequently as by non-ts vaccine virus. Thus virus could be reactivated in seven of eight ts vaccinates and six of eight non-ts vaccinates after dexamethasone treatment. Virus excretion could be detectable for 1 to 8 days at a level of 2 x 10(6) to 3 x 10(8) plaque-forming units per ml of nasal secretions. The reactivated virus was shown to be the same as the original virus used for vaccination by its inability to grow at the restrictive temperature (39 degrees C) as well as by its restriction endonuclease cleavage pattern.
Multitask Learning On Graph Neural Networks Applied To Molecular\n Property Predictions (2019)

Prediction of molecular properties, including physico-chemical properties, is\na challenging task in chemistry. Herein we present a new state-of-the-art\nmultitask prediction method based on existing graph neural network models. We\nhave used different architectures for our models and the results clearly\ndemonstrate that multitask learning can improve model performance.\nAdditionally, a significant reduction of variance in the models has been\nobserved. Most importantly, datasets with a small amount of data points reach\nbetter results without the need of augmentation.\n
The Impacts of In-Hospital Invasive Strategy on Long-Term Outcome in Elderly Patients with Non-ST-Elevation Myocardial Infarction. (2013)

Elderly; Invasive strategy; Myocardial infarction.
Functional Heterogeneity of Proto-Oncogene Tyrosine Kinases: the C Terminus of the Human Epidermal Growth Factor Receptor Facilitates Cell Proliferation (1989)

Previous reports have indicated that the C termini of the membrane-associated tyrosine kinases encoded by c-src and c-fms proto-oncogenes have a negative effect on their biological activity and that this effect is mediated by their C-terminal tyrosine residue. To determine whether this was true for the human epidermal growth factor (EGF) receptor, which is also a membrane-associated tyrosine kinase proto-oncogene, we have constructed two premature termination mutants, dc19 and dc63, that delete the C-terminal 19 and 63 amino acids, respectively, from the human full-length receptor (hEGFR). The smaller deletion removes the C-terminal tyrosine residue, while the larger deletion removes the two most C-terminal tyrosines; similar deletions are found in v-erbB. As previously shown for the gene encoding the full-length EGF receptor, the two C-terminal mutants induced EGF-dependent focal transformation and anchorage-independent growth of NIH 3T3 cells. However, both dc19 and dc63 were quantitatively less efficient than the gene encoding the full-length receptor, with dc63 being less active than dc19. Although the C-terminal mutants displayed lower biological activity than the gene encoding the full-length receptor, the mutant receptors were found to be similar in several respects to the full-length receptor. These parameters included receptor localization, stability in the absence of EGF, receptor half-life in the presence of EGF, EGF binding, extent of EGF-dependent autophosphorylation in vitro, and EGF-dependent phosphorylation of an exogenous substrate in vitro. Therefore, the C-terminal 63 amino acids of the human receptor have no detectable influence on EGF-dependent early events. We conclude that in contrast
High-Spin Nitrenes with s-Triazine Skeleton (1999)

Abstract Heteroatomic high-spin molecules are suitable for a model study of room-temperature stable molecular based magnetics. We studied high-spin nitrenes (S = 1 and 2) with s-triazine skeleton, which were generated by the photolysis of the polyazide precursor. We identified mononitrene 1 (S = 1) and bisnitrene 2 (S = 2) for the first time by single-crystal ESR measurements. The fine-structure parameters were determined by the angular dependence of resonance fields. The determined fine-structure parameters were |D| = 1.402 cm−1 and |D| = 0.280 cm−1 for mononitrene 1 and bisnitrene 2, respectively. The large D values indicate that π-spin delocalization effects were hampered by introducing heteroatoms to π-spin systems. The hyperfine splittings due to the monovalent nitrogen nucleus of 1 were observed with magnetic field along the principal axis of the fine structure tensor. The hyperfine splitting constant was about 0.0018 cm−1. The temperature dependence of ESR signals showed that 1 and 2 were triplet and quintet in the ground state, respectively.
Improved arterial visibility using short‐tau inversion‐recovery (STIR) fat suppression in non‐contrast‐enhanced time–spatial labeling inversion pulse (Time‐SLIP) renal MR angiography (MRA) (2009)

STIR fat suppression provides better renal artery contrast than CHESS fat suppression in non-contrast free-breathing Time-SLIP MRA; it is also an effective screening tool for renal artery stenosis because of the lack of interference from intestinal signals. However, close attention is needed if the patient has slow respiration. As the TI for the ssIR pulse decreases, the STIR method requires faster-paced respiration.
Therapeutic Plasma Concentrations of Epsilon Aminocaproic Acid and Tranexamic Acid in Horses (2013)

Current dosing schemes for EACA and TEA in horses may be as much as 20× higher than necessary, potentially increasing cost of treatment and risk of adverse effects.
A Small Decrease of Plastid Transketolase Activity in Antisense Tobacco Transformants Has Dramatic Effects on Photosynthesis and Phenylpropanoid Metabolism (2001)

Transketolase (TK) catalyzes reactions in the Calvin cycle and the oxidative pentose phosphate pathway (OPPP) and produces erythrose-4-phosphate, which is a precursor for the shikimate pathway leading to phenylpropanoid metabolism. To investigate the consequences of decreased TK expression for primary and secondary metabolism, we transformed tobacco with a construct containing an antisense TK sequence. The results were as follows: (1) a 20 to 40% reduction of TK activity inhibited ribulose-1,5-bisphosphate regeneration and photosynthesis. The inhibition of photosynthesis became greater as irradiance increased across the range experienced in growth conditions (170 to 700 micromol m(-2) sec(-1)). TK almost completely limited the maximum rate of photosynthesis in saturating light and saturating CO(2). (2) Decreased expression of TK led to a preferential decrease of sugars, whereas starch remained high until photosynthesis was strongly inhibited. One of the substrates of TK (fructose-6-phosphate) is the starting point for starch synthesis, and one of the products (erythrose-4-phosphate) inhibits phosphoglucose isomerase, which catalyzes the first reaction leading to starch. (3) A 20 to 50% decrease of TK activity led to decreased levels of aromatic amino acids and decreased levels of the intermediates (caffeic acid and hydroxycinnamic acids) and products (chlorogenic acid, tocopherol, and lignin) of phenylpropanoid metabolism. (4) There was local loss of chlorophyll and carotene on the midrib when TK activity was inhibited by >50%, spreading onto minor veins and lamina in severely affected transformants. (5) OPPP activity was not strongly inhibited by decreased TK activity. These results identify TK activity as an important determinant of photosynthetic and phenylpropanoid metabolism and show that the provision of precursors by primary metabolism colimits flux into the shikimate pathway and phenylpropanoid metabolism.
Definition and Characterization of a Peptide Warehouse for the Patient-Individualized Peptide Vaccination Study (iVAC-L-CLL01) after First Line Therapy of CLL (2017)

Abstract The treatment of chronic lymphocytic leukemia (CLL) has substantially advanced over the last decade with chemo/immunotherapy as standard of care achieving overall response rates up to 90%. However, besides allogeneic stem cell transplantation, so far no curative treatment for CLL is available. This is mostly due to the persistence of residual CLL cells after therapy (minimal residual disease, MRD), which cause disease relapse. Thus, novel strategies such as peptide-based immunotherapy aiming to eliminate MRD are needed to achieve lasting disease remission or even cure. With this aim, we implemented a first-in-man multi-centric clinical phase II study (iVAC-L-CLL01, NCT02802943), in which patient-individualized peptide vaccination with or without lenalidomide as systemic immune modulator is applied after first-line therapy of CLL. The peptide vaccine cocktail consists of 10 tumor-associated peptides selected according to the HLA ligandome of the individual patients from a pre-manufactured “peptide warehouse”. This peptide warehouse contains CLL-associated antigens, which are frequently and exclusively presented by HLA molecules on the surface of CLL cells. The peptides have been selected using a direct mass spectrometry based comparative analysis of the HLA ligandome of 30 CLL patients and a normal tissue ligandome database (Kowalewski et al. PNAS, 2015). The warehouse includes 35 HLA class I and 5 HLA class II peptides. The HLA class I peptides are restricted by the 7 most common HLA class I allotypes (A*01, A*02, A*03, A*24, B*07, B*08 and B*44). Prior to clinical application, the immunogenicity of the warehouse peptides was validated using different T-cell assays. We performed IFNg ELISpot assays using PBMC obtained from CLL patients and healthy donors. Peptide-specific memory T-cell responses were detected for 20/35 (57%) HLA class I peptides (A*01, A*02, A*03 and B*08) and 5/5 (100%) HLA class II peptides in samples obtained from CLL patients. Immune responses in healthy donors could not be detected for any of the 40 warehouse peptides, indicating a strictly CLL directed T-cell response. The immunogenicity of the remaining peptides could not be approved by detection of spontaneous memory T-cell responses in CLL patients due to lack of HLA-matched CLL-patient samples. Hence, we implemented artificial APC-based in vitro priming assays using CD8+ T cells of healthy donors proofing the ability of the peptides to prime naive CD8+ T cells. For all 15 analyzed peptides (HLA A*24, B*07 and B*44), an induction of tetramer positive CD8+ T cell populations with frequencies of 0.1-35.1% could be detected. Therefore, all 40 warehouse peptides could be confirmed as immunogenic T-cell epitopes The iVAC-L-CLL01 study is recruiting since October 2016. Vaccination of the first included study patient was performed in July 2017. Disclosures No relevant conflicts of interest to declare.
Biochemistry of bovine lens proteins. III. Chemical and physical properties of .alpha.-crystallin subunits (1968)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBiochemistry of bovine lens proteins. III. Chemical and physical properties of .alpha.-crystallin subunitsWinifred G. Palmer and John. PapaconstantinouCite this: Biochemistry 1968, 7, 1, 243–253Publication Date (Print):January 1, 1968Publication History Published online1 May 2002Published inissue 1 January 1968https://pubs.acs.org/doi/10.1021/bi00841a029https://doi.org/10.1021/bi00841a029research-articleACS PublicationsRequest reuse permissionsArticle Views29Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Relationship of the Adherence to a Mediterranean Diet and Its Main Components with CRP Levels in the Spanish Population (2018)

Cross-sectional analysis of 1411 subjects (mean age 61 years, 43.0% males) randomly selected from the general population. CRP levels were determined by a commercial ELISA kit. Adherence to the Mediterranean diet was measured by the 14-point MEDAS. <b>Results:</b> There was an inverse correlation between adherence to the Mediterranean diet and the CRP concentration, even after adjusting by age, gender, hypertension, metabolic syndrome, body mass index, statin treatment and hypertension treatment (<i>p</i> = 0.041). Subjects who consume ≥2 servings of vegetables per day (<i>p</i> = 0.003), ≥3 pieces of fruit per day (<i>p</i> = 0.003), ≥1 serving of butter, margarine, or cream per day (<i>p</i> = 0.041) or ≥3 servings of fish/seafood per week (<i>p</i> = 0.058) had significantly lower levels of CRP. <b>Conclusions</b>: Adherence to a Mediterranean-type diet measured by a simple questionnaire is associated with lower CRP concentration. However, this association seems to be particularly related to a higher consumption of vegetables, fruits, dairy products, and fish.
Preparation and characterization of Na<sub>2.88</sub>Sb<sub>0.88</sub>W<sub>0.12</sub>S<sub>4−</sub><i><sub>x</sub></i>O<i><sub>x</sub></i> solid electrolyte (2022)

For the practical application of all-solid-state batteries, it is necessary to improve the performance of the solid electrolytes. We previously reported the fabrication of Na2.88Sb0.88W0.12S4, which showed the highest ionic conductivity among Na+ conducting sulfide solid electrolytes. In this study, we focused on the anion substitution of Na2.88Sb0.88W0.12S4 and evaluated oxygen substitution. Samples of Na2.88Sb0.88W0.12S4−xOx (0 ≤ x ≤ 0.5) were fabricated by a mechanochemical process and subsequent heat treatment, and structural analysis and electrochemical evaluation were performed. The solid solution of oxygen was found to proceed in the range of x ≤ 0.3. The oxygen substitution decreased the ionic conductivity, but it maintained a high ionic conductivity of more than 10−3 S cm−1. The reduction tolerance was improved by the oxygen substitution based on cyclic voltammetry measurements. An all-solid-state Na–Sn/TiS2 cell using the Na2.88Sb0.88W0.12S3.7O0.3 electrolyte operated at room temperature.
Effect of zeolite additives on the formation of the active phases of aluminum-nickel-molybdenum catalysts (1988)

Thermogravimetric analysis, x-ray photoelectron spectroscopy, diffuse reflection electron spectroscopy, and Raman spectroscopy were used to study aluminum-nickel-molybdenum catalysts for hydropurification with different contents of the hydrogenating metals (Ni and Mo) with and without the addition of 5 mass % zeolite HY. The introduction of zeolite was found to give an increased interaction of Ni with Mo with the formation of surface aluminum-nickel-molybdenum aggregates even in the initial stage of catalyst preparation. The surface aluminum-nickel-molybdenum oxides formed as a result of thermal activation at 550/sup 0/C, which are precursors of the phases active in the hydropurification process, have higher dispersion in the ANM catalysis containing zeolite than in these catalysts without zeolite.
Three-Component Optically Compensated Varifocal System* (1962)

The general theory of optically compensated varifocal systems is applied to a three-component system composed of two movable components placed on either side of a fixed component. The two movable components are displaced in unison to change the over-all focal length of the system. The three-component system is analyzed in detail and an iteration method for the solution of the varifocal equations is developed which enables us to determine the Gaussian parameters of the system for any predetermined focal range in a matter of a few minutes (without the use of computers). Using this method, explicit expressions are found for the approximate values of the parameters of the optimum three-component systems as functions of the focal range. A numerical example is given to illustrate the iteration method.
A numerical and experimental investigation on passive piezoelectric shunt damping of mistuned blisks (2017)

In a previous study, we proposed a method for the damping of rotationally periodic structures, when a specific mode with n nodal diameters is targeted. The proposed method considers 4 n lead zirconate titanate patches (or a multiple of) which can be, either, shunted independently on 4 n identical resistor–inductor circuits, or mounted in two parallel loops and shunted on only two resistor–inductor circuits. Both configurations offer the same performance; however, the parallel configuration requires only two inductors and it is aimed to reduce the demand on inductors; it works actually like a spatial filter and assumes a perfectly symmetric structure with harmonic mode shapes in the circumferential direction. The study presented in this article is aimed at evaluating the proposed damping technique in the presence of blade mistuning. In the first part, the parallel and the independent configurations are compared numerically on a set of mistuned bladed drums with controlled level of mistuning. In the second part, the parallel and the independent shunts are implemented experimentally on a mistuned bladed drum mock-up. For the considered mock-up, the numerical results show that for moderate levels of mistuning, the parallel shunt performs almost like the independent shunt, while the experimental results confirm this fact.
Cholinergic-Anticholinergic Antagonism in Parkinsonism (1967)

<b>THE LIMITED</b>clinical efficacy of the belladonna alkaloids in the treatment of parkinsonism was first noted a century ago by Charcot and his student, Ordenstein.<sup>1</sup>Although an extraordinary number of pharmacological agents have been tried at various times in the 100 years which have elapsed since this early therapeutical trial, few have been found which can equal the effect of atropine, scopolamine, or stramonium, and none can truly be said to be appreciably more effective. The clinical use of these alkaloids in treating extrapyramidal disorders has been entirely based on empirical observation and was well established long before their fundamental mechanism of action as acetylcholine antagonists was understood. Thus, it seems significant that virtually all known medicinal preparations of botanical origin have been used in parkinsonism over the past century but that only those containing one or more of the belladonna alkaloids achieved enduring and widespread acceptance. Recognition of
Use of Proteins to Minimize the Physical Aging of EUDRAGIT® Sustained Release Films (2007)

The objective of this study was to investigate the influence of two proteins, albumin and type B gelatin, on the physical aging of EUDRAGIT RS 30 D and RL 30 D coated theophylline pellets. The physicomechanical properties of sprayed films, thermal properties of cast films, influence of proteins on the zeta potential and particle size of the dispersion, and the release of proteins from cast films under simulated dissolution conditions were investigated. The release rate of theophylline decreased significantly over time from pellets coated with an acrylic dispersion containing 10% albumin when there was no acidification of the acrylic dispersion; however, when pellets were coated with an acidified EUDRAGIT/albumin dispersion, the theophylline release rate was stable for dosage forms stored in the absence of humidity. The drug release rate was faster for pellets coated with acrylic dispersions containing 10% gelatin compared to the albumin-containing formulations. When sprayed films were stored at 40 degrees C/75% RH, the water vapor permeability decreased significantly for both EUDRAGIT films and those containing EUDRAGIT and albumin; however, there was no significant change in this parameter when 10% gelatin was present. Albumin was released from the acrylic films when the pH of the dissolution media was below the isoelectric point of the protein while no quantitative release of gelatin was observed in pH 1.2 or 7.4 media. The effect of gelatin to prevent the decrease in drug release rate was due to stabilization in water vapor permeability of the film. Acidification of the polymeric dispersion resulted in electrostatic repulsive forces between albumin and the acrylic polymer, which stabilized the drug release rate when the dosage forms were stored in aluminum induction sealed containers at both 40 degrees C/75% RH and 25 degrees C/60% RH.