gebhart/patrepeval huggingface dataset:
Characterization of a family of structurally related glycoproteins expressing β1-6-branched asparagine-linked oligosaccharides in human colon carcinoma cells (1992)

Previous studies have established that metastatic tumour cells express high levels of beta 1-6-branched Asn-linked oligosaccharides which can be detected with the lectin leucoagglutinin (L-PHA) [Dennis, Laferté, Waghorne, Breitman & Kerbel (1987) Science 236, 582-585]. In order to identify L-PHA-binding glycoproteins which may play a role specifically in colon cancer, we have prepared monoclonal antibodies (MAbs) to the moderately well-differentiated human colon carcinoma cell line HT29. In this paper we present the initial characterization of a family of structurally related L-PHA-binding glycoproteins detected by MAb 1H9 which are differentially expressed and processed by HT29 cells and by two other human colon carcinoma cell lines, SW480 and SW620. In contrast to HT29, the SW480 and SW620 cell lines were established from a poorly differentiated grade III/IV primary tumour and one of its lymph node metastases respectively. MAb 1H9 detects in HT29 cells a conformational determinant present on three L-PHA-binding glycoproteins of 100, 70 and 25kDa, as well as a 74 kDa glycoprotein with high-mannose-type Asn-linked oligosaccharides. Pulse-chase experiments and peptide mapping analyses revealed that the 74 kDa and 100 kDa species are related by carbohydrate processing and are probably derived from a common 76 kDa precursor. On the other hand, the 70 kDa glycoprotein is synthesized from an endoglycosidase H-sensitive precursor of 56 kDa which is structurally related to, but distinct from, the aforementioned 76 kDa precursor. In addition, the 100 kDa species is secreted into the culture medium, whereas the 70 kDa glycoprotein is retained intracellularly. SW480 and SW620 cells showed qualitative and quantitative differences from HT29 cells, including increased secretion of a smaller L-PHA-binding glycoprotein of 92 kDa into the culture medium, as well as apparent differences in glycosylation of the intracellular 66 kDa glycoprotein. These results suggested that the expression, glycosylation and subcellular localization of this family of L-PHA-binding glycoproteins may correlate with the differentiation status of colon cancer cells and/or reflect biochemical changes. characteristic of more progressive metastatic tumours.
GaAs Bi-FET RF front-end MMIC for WiMAX applications (2012)

A single-chip WiMAX RF front-end MMIC using GaAs Bi-FET process of WIN semiconductor corporation is presented. The MMIC integrates an HBT power amplifier, an E-mode pHEMT low-noise amplifier, and a D-mode pHEMT antenna switch. On-chip thermal and electrical isolation structures mitigate the interference problem from high-power devices. The MMIC delivers 24 dBm linear power of 64QAM 802.16e signal with 17% power-added efficiency at antenna switch output. The chip size is 1.85 mm × 1.1 mm.
Electronic Sensor Design Principles (2021)

Get up to speed with the fundamentals of electronic sensor design with this comprehensive guide, and discover powerful techniques to reduce the overall design timeline for your specific applications. Includes a step-by-step introduction to a generalized information-centric approach for designing electronic sensors, demonstrating universally applicable practical approaches to speed up the design process. Features detailed coverage of all the tools necessary for effective characterization and organization of the design process, improving overall process efficiency. Provides a coherent and rigorous theoretical framework for understanding the fundamentals of sensor design, to encourage an intuitive understanding of sensor design requirements. Emphasising an integrated interdisciplinary approach throughout, this is an essential tool for professional engineers and graduate students keen to improve their understanding of cutting-edge electronic sensor design.
Vector-MediatedIn VivoAntibody Expression (2015)

The holy grail of human immunodeficiency virus (HIV) vaccine development is an immunogen that elicits antibodies that neutralize field strains of the virus. In recent years, we have gained tremendous insights into the structure and function of the HIV envelope glycoprotein, but limited progress has been made in designing such immunogens. These sobering observations underscore the tremendous hurdles that must be overcome to develop an effective HIV vaccine (1, 2, 3, 4, 5). Foremost among these hurdles is the inability to induce antibodies that neutralize a wide array of HIV field isolates. Such antibodies are rare, and, until recently, only a handful of these antibodies had been isolated (6, 7, 8, 9). Over the past few years, a much larger number of HIV antibodies have been identified that have a much broader range of neutralization and are orders of magnitude more potent than the previously identified group (10, 11, 12, 13). These antibodies were isolated from the high-throughput screening of sera from HIV-1-infected individuals and categorized as “elite neutralizers” based on their neutralization breadth and potency (14). Extensive sequence analysis of these potent, broadly neutralizing antibodies revealed that high levels of somatic mutations were involved to generate the mature antibody (11). Furthermore, the maturation may have involved repeated rounds of antibody selection through HIV antigen interaction, a process that may not be possible to duplicate from a traditional HIV protein subunit or viral vector vaccine.
Free Charges, Polarization and Polarization Charges, Especially Those Produced When an Insulator Moves in a Magnetic Field (1939)

First Page
Bessel beam like emission characteristics of a neodymium-doped multicore fiber laser using a Talbot cavity (2000)

Summary form only given.In multicore fibers, single mode rare-earth doped waveguides (micro cores) are placed on a ring inside a large pumpcore. Therefore, the absorption length for the pump radiation can be dramatically reduced. To increase the on-axis irradiation, phase-coupling between the individual micro cores has to be established. One possibility to arrange phase-coupling is the employment of self-reproduction of the near-field distribution by interference after a certain distance of free space propagation. This self-reproduction is called Talbot effect and was investigated and applied to different types of laser-arrays.
Compilation of Energy Band Gaps in Elemental and Binary Compound Semiconductors and Insulators (1973)

Energy band gaps are tabulated for elemental and binary compound semiconductors and insulators reported in 723 references. The method of measurement, transition, type of sample, and other pertinent information are included for each entry. The determinations believed to be the most reliable are indicated.
Coexistence of metamagnetism and slow relaxation of magnetization in ammonium hexafluoridorhenate (2021)

The (NH<sub>4</sub>)<sub>2</sub>[ReF<sub>6</sub>] (1) salt was studied by X-ray diffraction, Raman spectroscopy, theoretical calculations, and magnetic measurements. 1 crystallizes in the trigonal space group <i>P</i>3̄<i>m</i>1 (Re-F = 1.958(5) Å). In the Raman spectrum of 1, splitting of the observed peaks was observed and correlated to the valence frequencies of vibration of the [ReF<sub>6</sub>]<sup>2-</sup> anion. The study of the magnetic properties of 1, through DC and AC magnetic susceptibility measurements, reveals the coexistence of metamagnetism and slow relaxation of magnetization at low temperature, which is unusual in the molecular systems based on the paramagnetic 5d metal ions reported so far.
Proprietes structurales et electroniques des films ultraminces de samarim et de thulium supportes sur metaux (1993)

Nous avons determine par aes et leed la structure de films ultraminces (0-2 monocouches) de samarium deposes sur ag(100) et cr(110) et de thulium deposes sur ag(100). Nous avons mesure par pes la valence du samarium ou du thulium adsorbe en fonction du taux de recouvrement. Pour tm/ag(100), a 130 k le thulium croit en multicouches simultanees sans interdiffuser. La valence passe de 2 pour l'atome isole a 3 pour les films epais. Les atomes divalents sont des atomes faiblement coordines (z<7). A 470 k se forme un compose de surface de structure ag17tm#2 ou le thulium est trivalent. Pour sm/ag (100), a 130 k se forme une monocouche mixte samarium-argent. Les atomes de samarium ayant interdiffuse sont trivalents, ceux qui se trouvent a l'extreme surface sont divalents (coordinence reduite). Pour sm/cr(110), a 300 k le samarium forme sans interdiffuser une succession de structure 2d epitaxiees (p(22), c(33)) jusqu'a la monocouche qui est constituee d'un arrangement hexagonal compact incommensurable. Jusqu'avant la structure hexagonale, les interactions substrat-adsorbat forcent les atomes de samarium a etre trivalents. Pour la structure hexagonale, les interactions entre adatomes sont preponderantes et le samarium a une valence intermediaire homogene egale a 2,8. La comparaison de nos resultats avec la litterature montre une difference de comportement entre le samarium adsorbe sur les metaux simples ou nobles et le samarium adsorbe sur les metaux d, et nous conduit a proposer une generalisation de ce comportement
Antisense Oligonucleotides Targeting Angiogenic Factors as Potential Cancer Therapeutics (2018)

Cancer is one of the leading causes of death worldwide, and conventional cancer therapies such as surgery, chemotherapy, and radiotherapy do not address the underlying molecular pathologies, leading to inadequate treatment and tumor recurrence. Angiogenic factors, such as EGF, PDGF, bFGF, TGF-β, TGF-α, VEGF, endoglin, and angiopoietins, play important roles in regulating tumor development and metastasis, and they serve as potential targets for developing cancer therapeutics. Nucleic acid-based therapeutic strategies have received significant attention in the last two decades, and antisense oligonucleotide-mediated intervention is a prominent therapeutic approach for targeted manipulation of gene expression. Clinical benefits of antisense oligonucleotides have been recognized by the U.S. Food and Drug Administration, with full or conditional approval of Vitravene, Kynamro, Exondys51, and Spinraza. Herein we review the scope of antisense oligonucleotides that target angiogenic factors toward tackling solid cancers.
Adipose tissue-derived mesenchymal stem cells differentiated into hepatocyte-like cells in vivo and in vitro (2014)

Cell‑based therapy is a potential alternative to liver transplantation. The goal of the present study was to examine the in vivo and in vitro hepatic differentiation potential of adipose tissue‑derived mesenchymal stem cells (AT‑MSCs) and to explore its therapeutic use. AT‑MSCs were isolated and cultured with hepatic differentiation medium. Bioactivity assays were used to study the properties of AT‑MSCs. The morphology of differentiated AT‑MSCs in serum‑free hepatic differentiation medium changed into polygonal epithelial cells, while the morphology of AT‑MSCs in a similar medium containing 2% fetal bovine serum remained unchanged. The differentiated cells cultured without serum showed hepatocyte‑like cell morphology and hepatocyte‑specific markers, including albumin (ALB) and α‑fetoprotein. The bioactivity assays revealed that hepatocyte‑like cells could take up low‑density lipoprotein (LDL) and store glycogen. Furthermore, trichostatin A (TSA) enhanced ALB production and LDL uptake by the hepatocyte‑like cells, analogous to the functions of human liver cells. ALB was detected in the livers of the CCl4‑injured mice one month post‑transplantation. This suggested that transplantation of the human AT‑MSCs could relieve the impairment of acute CCl4‑injured livers in nude mice. This therefore implied that adipose tissue was a source of multipotent stem cells which had the potential to differentiate into mature, transplantable hepatocyte‑like cells in vivo and in vitro. In addition, the present study determined that TSA was essential to promoting differentiation of human MSC towards functional hepatocyte‑like cells. The relief of liver injury following treatment with AT‑MSCs suggested their potential as a novel therapeutic method for liver disorders or injury.
Assessment of the microbiome during bacteriophage therapy in combination with systemic antibiotics to treat a case of staphylococcal device infection (2021)

Results from our proof-of-principal study supports the use of bacteriophages as a microbiome-sparing approach to treat bacterial infections. Video abstract.
OpenFLUX2: 13C-MFA modeling software package adjusted for the comprehensive analysis of single and parallel labeling experiments (2014)

The developed open-source OpenFLUX2 provides a friendly software environment that facilitates beginners and existing OpenFLUX users to implement LEs for steady-state (13)C-MFA including experimental design, quantitative evaluation of flux parameters and statistics.
Cultural Intelligence Twenty Years On: Where to From Here? (2023)

The concept of cultural intelligence was introduced to the management literature in 2003 (Early & Ang, 2003). Since then, hundreds of articles and dozens of books (see Caputo & Kargina, 2023) have drawn on this concept to help explain cross cultural interactions in organizational settings. In the first quarter of 2023 the Handbook of Cultural Intelligence Research (Thomas & Liao, 2023) will be released, which includes 27 chapters from 55 different authors representing 55 different countries. A subset of 12 authors will provide the panel for this symposium. The goal of the symposium is to build on the themes reflected in the handbook and to facilitate a discussion among the participants as to the future opportunities that each theme presents for cultural intelligence research. We hope to inspire the next generation of researchers to move beyond the mundane and repetitive mode that so often creeps into a field of study as it matures. The concept of cultural intelligence addresses one of the most pressing issues of our time; the understanding of intercultural interactions among individuals in groups, organizations, and society.
Spotlight on “Ultralow crosstalk Nanosecond-scale Nested 2x2 Mach-Zehnder Silicon Photonic Switch” (2016)

Fast switching in silicon photonics gets record performance. &#13;\nHigh-performance supercomputing and datacentre networks yearns for energy-efficient solutions for fast and high-capacity data switching in high-port-count nodes. Electronics is the current technology, but it is bound to resort soon to heavy parallelization and power-hungry multi-chip architectures; optical technologies already offer 3D-MEMS switches, which are however too slow for applications that require data-packet reconfiguration. Silicon photonics has the right stuff to become a key technology for low-power switch fabrics operating at nanosecond-scale. Yet, to date, high loss and high optical crosstalk limit the port-count of silicon photonic switches to a handful of I/Os. &#13;\nIn this Optics Letters article, N. Dupuis and coworkers present something that is likely to become a game-changing silicon photonic building block. The idea is rather simple indeed, essentially consisting of 2 × 2 nested-Mach-Zehnder switch where the conventional straight-line phase-shifter integrated in one arm is replaced by a Mach-Zehnder phase shifter. This design enables to fully exploit the energy-efficient and fast switching provided by free-carrier plasma dispersion effect in silicon waveguides, without paying the price of the inherent loss associated with free-carrier absorption. A record crosstalk value of -34.5 dB is achieved, with only 2 dB loss and a remarkably small switching time of 4 ns. &#13;\nEverything we need is monolithically integrated onto a small silicon chip, hosting the photonic switch, the CMOS driver and interface logic. Another brick in the silicon photonic route towards energy efficient computing networks has been added.
Attributed tree homomorphism using association graphs (2002)

The matching of hierarchical relational structures is of significant interest in computer vision and pattern recognition. We have recently introduced a new solution to this problem, based on a maximum clique formulation in an (derived) "association graph". This allows us to exploit the full arsenal of clique finding algorithms developed in the algorithm community. However, thus far we have only focussed on one-to-one correspondences (isomorphisms), which appears to be too strict a requirement for many vision problems. In this paper we provide a generalization of the association graph framework to handle many-to-one correspondences. We define a notion of an /spl epsiv/-homomorphism (a many-to-one mapping) between attributed trees, and provide a method of constructing a weighted association graph where maximal weight cliques are in one-to-one correspondence with maximal similarity subtree homomorphisms. We then solve the problem by using replicator dynamical systems from the evolutionary game theory.
ChemInform Abstract: Mechanism of Multidrug Resistant Tumors and Chemotherapeutic Approaches Against the Resistant Tumors (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ErbB2 overexpression on occult metastatic cells in bone marrow predicts poor clinical outcome of stage I-III breast cancer patients. (2001)

Occult hematogenous micrometastases are the major cause for metastatic relapse and cancer-related death in patients with operable primary breast cancer. Although sensitive immunocytochemical and molecular methods allow detection of individual breast cancer cells in bone marrow (BM), a major site of metastatic relapse, current detection techniques cannot discriminate between nonviable shed tumor cells and seminal metastatic cells. To address this problem, we analyzed the relevance of erbB2 overexpression on disseminated cytokeratin-18-positive breast cancer cells in the BM of 52 patients with locoregionally restricted primary breast cancer using immunocytochemical double labeling with monoclonal antibody 9G6 to the p185erbB2 oncoprotein. Expression of p185erbB2 on BM micrometastases was detected in 31 of 52 (60%) patients independent of established risk factors such as lymph node involvement, primary tumor size, differentiation grade, or expression of p185erbB2 on primary tumor cells. After a median follow-up of 64 months, patients with p185erbB2-positive BM micrometastases had developed fatal metastatic relapses more frequently than patients with p185erbB2-negative micrometastases (21 versus 7 events; P = 0.032). In multivariate analysis, the presence of p185erbB2-positive micrometastases was an independent prognostic factor with a hazard ratio of 2.78 (95% confidence interval, 1.11-6.96) for overall survival (P = 0.029). We therefore conclude that erbB2 overexpression characterizes a clinically relevant subset of breast cancer micrometastases.
Oil Possibilities of Belgium and Belgian Congo (1934)

The paper is a resume of the petroleum situation of Belgium and the Belgian Congo in the light of recent investigations. Three prospective areas in Belgium are described; of these, the Campine is considered as the most favorable. In the Belgian Congo two areas are discussed at some length, the Central basin and the Rift valleys. These offer some possibilities for commercial production.
Colonization of the gut of the blue crab (Callinectes sapidus) by Vibrio cholerae (1986)

Attachment of Vibrio cholerae to the mucosal surface of the intestine is considered to be an important virulence characteristic. Vibrio cholerae, an autochthonous member of brackish water and estuarine bacterial communities, also attaches to crustacea, a significant factor in multiplication and survival of V. cholerae in nature. The ability of V. cholerae to attach to the gut wall of the blue crab (Callinectes sapidus) was examined, and attachment was observed only in the hindgut and not the midgut of crabs, confirming a requirement for chitin in the attachment of V. cholerae to invertebrate and zooplankton surfaces. The new finding of attachment of V. cholerae to the hindgut of crabs may be correlated with the epidemiology and transmission of cholera in the aquatic environment. The crab model may also prove useful in elucidating the mechanism(s) of ion transport in crustacea.
Innovations in laser cladding (2000)

Laser beam build-up welding (cladding) is becoming increasingly established in automotive production, in the aerospace industry, as well as in mould and tool technology. Impulses for this development are the availability of the high power diodes, user-friendly systems, and new hybrid techniques for increased productivity and efficiency. A newly developed modular cladding head allows for easy integration of diode, YAG and CO2 lasers into machine systems. A mechanical finishing process can be optionally combined in the same machine. The modular head guarantees a stable and controllable cladding process as well as the highest precision in material deposition. For higher cladding rates and lower specific coating costs, innovative developments are aimed at combining laser build-up welding and a “conventional” plasma spraying process. In a one-step process, the laser beam interacts directly with the plasma flame to generate the coating. The coatings are entirely dense and metallurgically bonded to the substrate. Using a 1.3 kW diode laser and a 30 kW plasma spray gun, the cladding speed is increased by a factor of up to 30 compared with “pure” laser cladding. At the same time, the generated structures retain the good properties of laser-clad coatings.
Innovate Kentucky Interview (2013)

I was interviewed by Josh Raymer of Innovate Kentucky regarding my upcoming (8/29/2013) presentation at the Kentucky Innovation and Entrepreneurship Conference in Lexington, KY. I get to speak a bit regarding my software, Peaklet Analysis, and the collaborations that lead to it, as well as other issues in STEM and mathematics education.
Human Evolution beyond Biology and Culture: Evolutionary Social, Environmental and Policy Sciences (2018)

Both natural and cultural selection played an important role in shaping human evolution. Since cultural change can itself be regarded as evolutionary, a process of gene-culture coevolution is operative. The study of human evolution - in past, present and future - is therefore not restricted to biology. An inclusive comprehension of human evolution relies on integrating insights about cultural, economic and technological evolution with relevant elements of evolutionary biology. In addition, proximate causes and effects of cultures need to be added to the picture - issues which are at the forefront of social sciences like anthropology, economics, geography and innovation studies. This book highlights discussions on the many topics to which such generalised evolutionary thought has been applied: the arts, the brain, climate change, cooking, criminality, environmental problems, futurism, gender issues, group processes, humour, industrial dynamics, institutions, languages, medicine, music, psychology, public policy, religion, sex, sociality and sports.