gebhart/patrepeval huggingface dataset:
Long-range allostery mediates the regulation of plasminogen activator inhibitor-1 by cell adhesion factor vitronectin (2022)

The serpin plasminogen activator inhibitor 1 (PAI-1) spontaneously undergoes a massive structural change from a metastable and active conformation, with a solvent-accessible reactive center loop (RCL), to a stable, inactive, or latent conformation, with the RCL inserted into the central β-sheet. Physiologically, conversion to the latent state is regulated by the binding of vitronectin, which hinders the latency transition rate approximately twofold. The molecular mechanisms leading to this rate change are unclear. Here, we investigated the effects of vitronectin on the PAI-1 latency transition using all-atom path sampling simulations in explicit solvent. In simulated latency transitions of free PAI-1, the RCL is quite mobile as is the gate, the region that impedes RCL access to the central β-sheet. This mobility allows the formation of a transient salt bridge that facilitates the transition; this finding rationalizes existing mutagenesis results. Vitronectin binding reduces RCL and gate mobility by allosterically rigidifying structural elements over 40 Å away from the binding site, thus blocking transition to the latent conformation. The effects of vitronectin are propagated by a network of dynamically correlated residues including a number of conserved sites that were previously identified as important for PAI-1 stability. Simulations also revealed a transient pocket populated only in the vitronectin-bound state, corresponding to a cryptic drug-binding site identified by crystallography. Overall, these results shed new light on PAI-1 latency transition regulation by vitronectin and illustrate the potential of path sampling simulations for understanding functional protein conformational changes and for facilitating drug discovery.
Coordination in innovative design and engineering (2010)

Coordinating activities across groups in systems engineering or product development projects is critical to project success, but substantially more difficult when the work is innovative and dynamic. It is not clear how technology should best support cross-group collaboration on these types of projects. Recent work on coordination in dynamic settings has identified cross-boundary knowledge exchange as a critical mechanism for aligning activities. In order to inform the design of collaboration technology for creative work settings, we examined the nature of cross-group knowledge exchange in an innovative engineering research project developing a lunar rover robot as part of the Google Lunar X-Prize competition. Our study extends the understanding of communication and coordination in creative design work, and contributes to theory on coordination. We introduce four types of cross-team knowledge exchange mechanisms we observed on this project and discuss challenges associated with each. We consider implications for the design of collaboration technology to support cross-team knowledge exchange in dynamic, creative work environments.
Syntheses, Characterization, and Magnetic Properties of Four New Layered Transition-Metal Hydroxyl−Carboxylate−Phosphonates:  [M(CH(OH)(CO2)(PO3H))(H2O)2] (M = Mn, Fe, Co, Zn) (2005)

Four new layered transition-metal hydroxyl−carboxylate−phosphonates, [M(CH(OH)(CO2)(PO3H))(H2O)2] (M = Mn (1), Fe (2), Co (3), Zn (4)), have been successfully hydrothermally synthesized and characterized by single-crystal X-ray diffraction as well as with elemental analysis, infrared spectroscopy, thermogravimetric analysis, and magnetic measurement. These isomorphous compounds crystalline in the monoclinic space group P21/c with a = 5.678(2)−5.800(2) Å, b = 15.469(6)−15.664(5) Å, c = 7.846(3)−7.911(2) Å, β = 109.287(4)−110.332(3)°, V = 649.5(4)−676.5(4) Å3, and Z = 4. In these compounds, transition-metal [MO6] (M = Mn, Fe, Co, Zn) octahedra and [PCO3] tetrahedra are connected to each other through corners into an infinite wriggled chain. Carboxylate and hydroxyl groups interlace the chain to form an organic−inorganic hybrid layered structure. The results of magnetic measurements revealed the presence of antiferromagnetic interactions of M(II) ions (M = Mn, Fe, Co) in compounds 1−3, respectively.
Continuous thermosalinograph oceanography along HEINCKE cruise track HE406 (2016)

Kasten, Sabine; Rohardt, Gerd (2016): Continuous thermosalinograph oceanography along HEINCKE cruise track HE406 [dataset]. Alfred Wegener Institute, Helmholtz Centre for Polar and Marine Research, Bremerhaven, PANGAEA, https://doi.org/10.1594/PANGAEA.859772
Qualitative separation of the effect of the solubility parameter on the recovery behavior of shape-memory polymer (2009)

For the thermal response of shape-memory polymer (SMP) it has been experimentally demonstrated that the actuation can be achieved using interactive solvent. In this paper, the effect of the solubility parameter of the interactive solvent on the shape recovery behavior and glass transition temperature of polystyrene SMP was investigated experimentally. The effect of the solubility parameter on the activation energy was separated and qualitatively identified, as expected from the relaxation theory and Eyring equation. This approach should be applicable to other SMPs and their composites and many extension applications and achievements could be based on this outcome.
Influence of Bisoprolol on Blood Glucose, Glucosuria, and Haemoglobin A1 in Noninsulin-Dependent Diabetics (1985)

In a double-blind crossover study, the influence of bisoprolol and placebo was tested in 20 noninsulin-dependent diabetics with concomitant essential hypertension. A 2-week washout placebo period was followed by two treatment periods of 2 weeks each with 10 mg bisoprolol or placebo. Compared with placebo, bisoprolol did not change blood glucose, haemoglobin A1 (HbA1), and glucosuria. No hypoglycaemia was observed. Serum cholesterol and triglyceride levels remained constant. Systolic (SBP) and diastolic (DBP) blood pressure, and heart rate (HR) were significantly (p less than 0.01) reduced after 2 weeks of bisoprolol therapy, compared with placebo. It was concluded that bisoprolol, in a dose therapeutically effective in essential hypertension, has no influence on carbohydrate and lipid metabolism in noninsulin-dependent patients with diabetes mellitus; and 10 mg bisoprolol is effective for the normalisation of SBP and DBP in mildly hypertensive diabetics. Since bisoprolol was well tolerated in the dosage studied, it can be recommended for noninsulin-dependent diabetics with hypertension.
Contraception: A User's Handbook (1994)

INTRODUCTION 1. CONCEPTION: HOW IT HAPPENS 2. HOW THE PILL WAS DEVELOPED 3. THE COMBINED PILL: WEIGHING UP THE PROS AND CONS 4. WHICH PILL WILL SUIT ME BEST? 5. PRACTICAL ASPECTS OF TAKING THE COMBINED PILL 6. THE PROGESTOGEN-ONLY PILL 7. INJECTABLE PROGESTOGENS AND IMPLANTS 8. INTRAUTERINE DEVICES 9. BARRIER METHODS: CAPS AND CONDOMS 10. NATURAL FAMILY PLANNING 11. EMERGENCY CONTRACEPTION: NOT ONLY FOR THE MORNING AFTER 12. CONTRACEPTION AT SPECIAL TIMES 13. WHAT ABOUT MEN? 14. STERILIZATION AND VASECTOMY 15. THE FUTURE FURTHER READING USEFUL ADDRESSES INDEX
Content Recommendation on Small Scale Sparse Social Network (2021)

Small scale social network platforms suffer from increased sparsity, both in the size of text posted by users and the number of posts, as well as the specific nature of kurtosis that affects all platforms, yet more so on an emerging platform. In this work we examine a dataset from such a platform, where the majority of the activity is in the form of user generated text; both posted content and comments left on those posts. We inquire into what techniques would present suitable recommendations for a platform with a similar characteristic dataset. We evaluate leading textual analysis techniques and show how topic-model based techniques present a viable means for recommendation on such a platform as compared to other simpler, or more advanced techniques.
Les Techniques Multi-Antennes pour les Réseaux Sans Fil (2004)

International audience
Application of numerical grid generation to scattering from rough penetrable ocean bottoms (1993)

Numerical grid generation methods have recently been applied with success to atmospheric sound propagation over irregular terrain [Di etal., J. Acoust. Soc. Am 92, 2431 (A) (1992)]. Here, the method was applied to scattering from rough ocean bottoms that allow sound to penetrate into the sediment. Considered are some simple geometries for which analytic results exist as well as more complex geometries that are treated numerically. Of interest are the relative contributions from surface scattering and volume scattering to the total acoustic backscatter. The ultimate objective of the investigation is to arrive at a simple, physically intuitive formulation that will aid in the interpretation of backscatter data from complex coastal environments. [Work supported by ONR.]
Crystal Structure, Magnetic Behavior and Valence State of Ytterbium in the Yb4Ni10+xGa21‐x Phase. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Design of a 1 kV bidirectional DC-DC converter with 650 V GaN transistors (2018)

This paper presents a bidirectional 4-level flying capacitor multi-level (FCML) converter for high voltage (> 1 kV) step-down/step-up conversion needed in hybrid rail and electric vehicle applications. Previous work achieved similar input voltage requirements through increasing the number of levels in the FCML, at the cost of additional transistors, flying capacitors and control complexity. In this work, we investigate the application of 650 V GaN transistors and apply a cascaded bootstrap method to supply the isolated gate drivers. We also analyze the performance benefits and limitations of zero-voltage switching (ZVS) in FCML converters. The design employs a single-sided PCB to improve the design flexibility for backside heat sinking. We demonstrate the design with an experimental prototype that achieves up to 1 kV operation at 2 kW with excellent flying capacitor balancing, a peak efficiency of 98.4% and a power density of 1500 W/in <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> .
Adaptive flux weakening control of switched reluctance machines in rotating reference frame (2013)

An adaptive flux weakening method for wide speed range operation of switched reluctance motors (SRM) is proposed in this paper. This method is based on SRM control in the dq rotating reference frame. This dq control of SRM mimics the control of synchronous machines (SM) by looking at the torque per phase as the product of sinusoidal inductance related term and current related terms. Hence, flux weakening can be applied using the dq control method to SRM for providing flux weakening. The proposed adaptive control method uses the commanded and actual currents to adaptively determine the required amount of flux weakening. Through the unique features of dq controls, the proposed method increases the average torque production supporting a wide speed range of operation for SRMs. The proposed control method is verified through simulations and hardware experiments.
System Performance of Fixed Beams with S-CPICH as a Phase Reference in WCDMA (2006)

A Fixed Beam (FB) system that uses a beam specific Secondary-Common PIlot CHannel (S-CPICH) as a phase reference for channel estimation and demodulation in WCDMA is evaluated in a dynamic radio network simulator. The impact of the angular spread on the DownLink (DL) system performance is analyzed. Furthermore, various scrambling code allocation strategies and an adaptive load-dependent power tuning algorithm of the common channels are proposed and evaluated. Extensive simulation results have verified that increasing the number of FB from 1 to 2 or 4 beams per sector in a typical urban radio channel yields significant DL capacity gains.
Utilisation of fuzzy sets for system modelling and control (1977)

Since L. A. Zadeh introduced fuzzy-set theory it has allowed a better grasp of certain systems in various fields, for instance, the modelization of process control. For a human observer can often supply subjective information about the evolution, the operation, or the value of certain parameters of a process he is acquainted with; and fuzzy set theory, by formalizing this subjective perception, allows one to achieve a first approach to modelizing the process, or to complete or confirm the results of objective analysis and measurements. In such a research orientation, this article devotes its first part to the formalism required for representing processes in the fuzzy system concept and in the second part, presents a method for calculating a regulation algorithm using a fuzzy model of the process.
Metallic stents in the biliary tree (1999)

SummaryThis paper outlines the types of metallic biliary stents available for use in malignant biliary disease. The results of various world-wide clinical trials are summarised. The future role of metallic biliary stents in malignant biliary obstruction is discussed.
Capillary Filling of Anodized Alumina Nanopore Arrays (2006)

The filling behavior of a room temperature solvent, perfluoromethylcyclohexane, in approximately 20 nm nanoporous alumina membranes was investigated in situ with small angle x-ray scattering. Adsorption in the pores was controlled reversibly by varying the chemical potential between the sample and a liquid reservoir via a thermal offset, DeltaT. The system exhibited a pronounced hysteretic capillary filling transition as liquid was condensed into the nanopores. These results are compared with Kelvin-Cohan theory, with a modified Derjaguin approximation, as well as with predictions by Cole and Saam.
Motor neuronal and glial apoptosis in the adult facial nucleus after intracranial nerve transection (2006)

These findings may ultimately lead to new therapeutic strategies in patients suffering from facial nerve palsy due to an intracranial lesion.
Analogues of the Lavallo–Grubbs Compound Fe3(C8H8)3: Equilateral, Isosceles, and Scalene Metal Triangles in Trinuclear Cyclooctatetraene Complexes M3(C8H8)3 of the First Row Transition Metals (M = Ti, V, Cr, Mn, Fe, Co, and Ni) (2011)

The trinuclear derivative Fe(3)(C(8)H(8))(3) was synthesized in 2009 by Lavallo and Grubbs via the reaction of Fe(C(8)H(8))(2) with a bulky heterocyclic carbene. This fascinating structure is the first example of a derivative of the well-known Fe(3)(CO)(12) in which all 12 carbonyl groups have been replaced by hydrocarbon ligands. The density functional theory predicts a structure having a central Fe(3) equilateral triangle with ∼2.9 Å Fe-Fe single bonded edges bridged by η(5),η(3)-C(8)H(8) ligands. This structure is close to the experimental structure, determined by X-ray crystallography. The related hypoelectronic M(3)(C(8)H(8))(3) derivatives (M = Cr, V, Ti) are predicted to have central scalene M(3) triangles with edge lengths and Wiberg bond indices (WBIs) corresponding to one formal single M-M bond, one formal double M═M bond, and one formal triple M≡M bond. For Mn(3)(C(8)H(8))(3), both a doublet structure with one Mn═Mn double bond and two Mn-Mn single bonds in the Mn(3) triangle, and a quartet structure with two Mn═Mn double bonds and one Mn-Mn single bond are predicted. The hyperelectronic derivatives M(3)(C(8)H(8))(3) have weaker direct M-M interactions in their M(3) triangles, as indicated by both the M-M distances and the WBIs. Thus, Ni(3)(C(8)H(8))(3) has bis(trihapto) η(3),η(3)-C(8)H(8) ligands bridging the edges of a central approximately equilateral Ni(3) triangle with long Ni···Ni distances of ∼3.7 Å. The WBIs indicate very little direct Ni-Ni bonding in this Ni(3) triangle and thus a local nickel environment in the singlet Ni(3)(C(8)H(8))(3) similar to that observed for diallylnickel (η(3)-C(3)H(5))(2)Ni.
Simple Conversion of Esters to Primary Amides Using Magnesium Nitride (2008)

A direct conversion of esters to primary amides is relatively difficult to perform, and, usually, a complicated three-step sequence is required to effect this transformation. The use of readily available and easy-to-handle magnesium nitride offers an elegant and quite convenient one-step solution for this problem. The reaction gives good yields even with difficult substrates like tert-butyl α,β-unsaturated esters.
Diversity‐Based Identification of Efficient Homochiral Organometallic Catalysts for Enantioselective Synthesis (2002)

This chapter contains sections titled: Introduction Factors Critical to the Success of Diversity-based Reaction Development Peptidic Schiff Bases as Chiral Ligands Ti-Catalyzed Enantioselective Addition of Cyanide to Meso Epoxides Ti-Catalyzed Enantioselective Addition of Cyanide to Imines Zr-Catalyzed Enantioselective Addition of Dialkyl Zincs to Imines Cu-Catalyzed Enantioselective Addition of Dialkyl Zincs to Allylic Phosphates: Pyridyl Dipeptides as Chiral Ligands Cu-Catalyzed Enantioselective Conjugate Addition of Dialkyl Zincs to Unsaturated Ketones: Peptidic Phosphines as Chiral Ligands Conclusions and Outlook Acknowledgments Endnotes and References
Polarisation insensitive and tuneable optical addand dropmultiplexer utilising vertically stacked buriedsemiconductor waveguides (1999)

A polarisation insensitive and tuneable optical add and drop multiplexer has been realised by utilising vertically stacked buried semiconductor waveguides. The difference in peak wavelength of the dropped light between the two orthogonal polarisations was as small as 0.03 nm, which is much smaller than the 3 dB bandwidth of 0.4 nm. The difference in peak power was also as small as 0.7 dB. Furthermore, polarisation insensitivity was maintained even during wavelength tuning.
The solution behavior of unsaturated molybdenum carbonyl species as evidenced via stereospecific carbon-13 monoxide labeling studies (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe solution behavior of unsaturated molybdenum carbonyl species as evidenced via stereospecific carbon-13 monoxide labeling studiesDonald J. Darensbourg and Albrecht SalzerCite this: J. Am. Chem. Soc. 1978, 100, 13, 4119–4124Publication Date (Print):June 1, 1978Publication History Published online1 May 2002Published inissue 1 June 1978https://pubs.acs.org/doi/10.1021/ja00481a022https://doi.org/10.1021/ja00481a022research-articleACS PublicationsRequest reuse permissionsArticle Views104Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
New Insights Into Optimal Acoustic Feedback Cancellation (2013)

In this letter, we present new insights into the bias problem for acoustic feedback cancellation when a probe signal approach is used. The optimum solution of the feedback canceler is not the feedback path but the product of the feedback path and the sensitivity function and hence, the solution is biased. The novelty of this paper also consists of the derivation of the conditions for unbiased feedback cancellation when a probe signal is used as input to the canceler. An adequate delay in the forward path is necessary to reduce, or remove the bias term. The theoretical analysis is verified with simulation results.
Casas sin gente, gente sin casas: el fracaso del modelo inmobiliario español (2014)

El estallido de la burbuja inmobiliaria en Espaa ha sacado a la luz todas las contradicciones y debilidades de un modelo que haba sido calificado como ejemplar y que an se pretende imitar en muchos pases. La paradoja de un stock sobredimensionado de viviendas conviviendo con una gran demanda insatisfecha; el hundimiento de un sistema financiero volcado en una burbuja especulativa; la avalancha de desahucios, con cientos de miles de familias que pierden sus viviendas; o el fracaso de la promesa de promocin social asociada a la propiedad de la vivienda, son algunas de las consecuencias de este colapso.
An Experimental 560 Mbits/s Repeater with Integrated Circuits (1977)

The bandwidth penalty of digital systems is very obvious in the case of transmission over coaxial cables because of the exponential increse of cable attenuation with square root of frequency. From capacity point of view, it is only at very high information rates (> 500 Mbit/s typically) that a digital system might be competitive with an analog system, because the disadvantage of noise accumulation in an analog system ultimately cancels the bandwidth penalty of the digital system. In addition, it is, however, difficult to realize common functions, such as amplification, equalization, regeneration, clock extraction, etc. with electronic components having a frequency range comparable to the frequency range of the information signal, which extends from zero frequency to the microwave range. Besides, the complexity of a regenerative repeater should be kept to a minimum for reliability reasons. It is shown in the paper that with present-day technology a 560 Mbit/s repeater can be constructed, operating in sections of 1.5 km coaxial cable (2.6/9.5 mm). Also, we demonstrate that new technologies exist which may lead to repeaters with a high degree of monolithic integration, even at such a speed, which is important from the reliability viewpoint. The constructed and described repeater is characterized by unconventional and economic design of amplifier/equalizer and clock extractor and by monolithically integrated decision circuits.
Synthesis of new indole benzylic alcohols as potential precursors of calixindoles (2008)

3-(4-Chlorophenyl)-4,6-dimethoxyindole 8 was converted into the 7-and 2-substituted glyoxylamide derivatives 11 and 12, which were in turn reduced by sodium borohydride to the corresponding benzylic alcohols 13 and 14. Indole 8 was also acylated via a Houben-Hoesch reaction, with benzyl cyanides to give the 7-substituted methylene ketones 16a-c, which were also reduced by sodium borohydride to the corresponding benzylic alcohols 17a-c. All the benzylic alcohols were subjected to a variety of acidic conditions, but failed to generate calixindoles.
Flüssigkristalline 4‐Bicyclohexylcarbonitrile mit außergewöhnlichen physikalischen Eigenschaften (1984)

Flüssigkristalle trotz einer axialen Cyangruppe bilden die Verbindungen 2 , die aus Edukten 1 mit äquatorialer Cyangruppe hergestellt wurden. Nach bisherigen Theorien ist zwar das flüssigkristalline Verhalten von 1 , nicht aber das von 2 zu erklären. magnified image