gebhart/patrepeval huggingface dataset:
2,4-Diaminothieno[2,3-d]pyrimidine Lipophilic Antifolates as Inhibitors of Pneumocystis carinii and Toxoplasma gondii Dihydrofolate Reductase. (2002)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correction2,4-Diaminothieno[2,3-d]pyrimidine Lipophilic Antifolates as Inhibitors of Pneumocystis carinii and Toxoplasma gondii Dihydrofolate Reductase.Andre Rosowsky, Andrew T. Papoulis, and Sherry F. QueenerCite this: J. Med. Chem. 2002, 45, 9, 1957Publication Date (Web):March 14, 2002Publication History Published online14 March 2002Published inissue 1 April 2002https://pubs.acs.org/doi/10.1021/jm020059bhttps://doi.org/10.1021/jm020059bcorrectionACS PublicationsCopyright © 2002 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views369Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (12 KB) Get e-Alertsclose Get e-Alerts
Regulation of NF‐κB Action by Reversible Acetylation (2004)

While the proximal cytoplasmic signalling events controlling the activation of NF-kappaB are understood in considerable detail, the subsequent intranuclear events that regulate the strength and duration of NF-kappaB action remain poorly defined. Recently, we have demonstrated that the RelA subunit of the NF-kappaB heterodimer is subject to reversible acetylation. The p300/CBP acetyltransferases play a major role in the in vivo acetylation of RelA principally targeting lysines 218, 221 and 310 for modification. Acetylation of these distinct lysine residues regulates different functions of NF-kappaB, including transcriptional activation, DNA binding affinity, I-kappaBalpha assembly and subcellular localization. Specifically, acetylation of lysine 221 enhances DNA binding and impairs assembly with I-kappaBalpha while acetylation of lysine 310 is required for full transcriptional activity of RelA independent of changes in DNA binding or I-kappaBalpha binding. In turn, acetylated RelA is deacetylated by histone deacetylase 3 (HDAC3). Deacetylation of lysine 221 promotes high-affinity binding of RelA to newly synthesized I-kappaBalpha proteins whose expression is activated by NF-kappaB. I-kappaBalpha binding to deacetylated RelA promotes rapid nuclear export of the NF-kappaB complex. This export is dependent on CRM1 binding to a nuclear export signal present in I-KBalpha and promotes replenishment of the cytoplasmic pool of latent NF-kappaB/I-kappaBalpha complexes thus readying the cell for response to the next NF-kappaB inducing stimulus Together, these studies highlight how reversible acetylation of RelA serves as an intranuclear molecular switch promoting both positive and negative regulatory effects on nuclear NF-kappaB action.
Activity of Tubercidin against Immature Fasciola hepatica in Mice (1976)

HaM/ICR females mice (20 to 25 g), infected with from 3 to 5 Fasciola hepatica metacercariae per os, were treated with a single dose of thepurine nucleoside analog tubercidin (7-deaza-adenosine; Tu) 7, 14, 21, and 28 days postexposure.Tu was administered either by direct intravenous injection or intraerythrocytically. Most of the flukes were killed and host survival rates were markedly increased if treatment was started within 3 weeks postexposure. The minimal single intravenous dose of Tu that was maximally effective was between 10 and 20 mg/kg.
A Low-Noise Switched-Capacitor Front End for Capacitive Sensor (2007)

This paper presents the analysis and design of an integrated low-noise switched-capacitor front-end circuit for capacitive sensors. The interface has been implemented with a relaxation oscillator. To prevent overload of the input amplifier for large input signals, a negative-feedback circuit controls the charge-transfer speed. It is shown; that this negative feedback can also be used to optimize the noise performance of the interface. The circuit has been designed and implemented in 0.7 mum standard CMOS technology. The effects of any additive and multiplicative interface errors have been reduced by applying three-signal auto-calibration. Experimental results show that application of negative feedback yields a resolution of more than 16 bits for measurement time of about 100 ms, which is at least 1 bit better than that of an earlier designed interface.
Design and Parameter Optimization of a Three-claw Underastatctuated Gripper (2018)

The humanoid end effector has a better performance when grabbing irregular objects. Compared to a full-drive dexterous robot hand, the underactuated gripper has a more compact structure, simpler control, and good self-adaptive ability, it can be applied to different shapes of objects. However, in some cases, improper design will lead to uneven grasping force, and it will not be able to grasp firmly or even have ejection phenomenon. So the optimization of the geometrical parameters is of great importance. In this paper, according to the designed three-degrees-of-freedom link-type underactuated manipulator, the mechanical model under grasping state is deduced by the principle of virtual work. Setting the average degree of grasping force as the optimization goal, the size and angle of pressure have been optimized by using MATLAB genetic algorithm toolbox and several suitable results have been obtained.
Low-energy vibrations of NH3 and CO adsorbed on Fe(110) (1992)

The low energy vibrations of NH3 and CO molecules adsorbed on Fe(110) have been investigated with inelastic He-atom scattering. For ammonia an energy loss of 10 meV was observed in the time-of-flight spectra and is assigned to the frustrated translations. Previously, this mode had only been observed for adsorbed CO molecules. For CO on Fe(110) the energy of the frustrated translations is 4.6 meV and the observed linewidth is smaller than 0.6 meV.
Estimating 3D Respiratory Motion from Orbiting Views (2006)

This paper describes a method for estimating 3D respiratory motion so as to characterize tumor motion. This method uses two sets of measurements. One is a reference thorax volume obtained from a conventional fast CT scanner under breath-hold condition. The other is a sequence of projection views of the same patient (acquired at treatment time) using a slowly rotating cone-beam system (1 minute per rotation) during free breathing. We named this method deformation from orbiting views (DOV). Breathing motion over the entire acquisition period is estimated by deforming the reference volume through time so that its projections best match the measured projection views. The nonrigid breathing motion is described by a B-spline based deformation model. The parameters of this model are estimated by minimizing a regularized squared error cost function, using a conjugate gradient descent algorithm. Performance of this approach was evaluated by simulation. Results showed good agreement between the estimated and synthesized motion, with a mean absolute error of 1.63 mm. Relatively larger errors tended to occur in uniform regions, which would not have significant effects on generating deformed volumes based on the estimated motion. The results indicate that it is feasible to estimate realistic nonrigid motion from a sequence of slowly rotating cone beam projection views.
Volumetric two-photon fluorescence imaging of live neurons using a multimode optical fiber (2020)

Multimode optical fibers (MMFs), combined with wavefront control methods, have achieved minimally invasive in vivo imaging of neurons in deep-brain regions with diffraction-limited spatial resolution. Here, we report a method for volumetric two-photon fluorescence imaging with a MMF-based system requiring a single transmission matrix measurement. Central to this method is the use of a laser source able to generate both continuous wave light and femtosecond pulses. The chromatic dispersion of pulses generated an axially elongated excitation focus, which we used to demonstrate volumetric imaging of neurons and their dendrites in live rat brain slices through a 60 µm core MMF.
In situ and real time electroporation of a lipid producing microalgae in a microfluidic device (2015)

International audience
Scalable SLAM building conditionally independent local maps (2007)

Local maps algorithms have demonstrated to be well suited for mapping large environments as can reduce the computational cost and improve the consistency of the final estimation. In this paper we present a new technique that allows the use of local mapping algorithms in the context of EKF SLAM but without the constrain of probabilistic independence between local maps. By means of this procedure, salient features of the environment or vehicle state components as velocity or global attitude, can be shared between local maps without affecting the posterior joining process or introducing any undesirable approximations in the final global map estimate. The overload cost introduced by the technique is minimum since building up local maps does not require any additional operations apart from the usual EKF steps. As the algorithm works with covariance matrices, well-known data association techniques can be used in the usual manner. To test the technique, experimental results using a monocular camera in an outdoor environment are provided. The initialization of the features is based on the inverse depth algorithm.
Synthesis and Helix Pitch Control of ^|^pi;-Conjugated Helical Polymers with Accordion-like Oscillation (2014)

Poly(alkyl propiolate)s (PAP), e.g., Poly(n-heptyl propiolate) (PnHepP) and Poly((s)-2-octyl propiolate) (Ps2OctP) having an achiral or a chiral ester side chain were stereoregularly prepared with a Rh complex catalyst, [Rh(nbd)Cl]2 (nbd=norbornadiene), at 40 °C in methanol, respectively. The temperature dependence 1H and 13C NMR spectra of PAPs and their spectral simulations indicated that the restricted rotation around the ester O-C bond takes place through the so-called 3-site jump conformation. The spectra also exhibited that the helical conjugated main-chain of Ps2OctP was largely oscillating between the sequences of contracted helix and stretched helix in the time scale of the NMRs, although the degree of the oscilation of PnHepP was fairly small compared to that of Ps2OctP. The UV-vis and IR spectra of them supported that PAPs have at least two helical conformations, i.e., contracted and stretched helices. Therefore, these spectra supported the oscillation of the helix along the main-chain axis. The proposed model calculated by MMFF94 also indicated the accordion-like helix oscillation of contracted and stretched helices (HELIOS) of PAPs which was synchronized with restricted 3-site jump rotation around the ester O-C bond in the side-chain.
Advances in Automated Coupling of CFD and Radiation (2008)

&lt;div class="htmlview paragraph"&gt;Research and development engineers have paid much attention to coupling commercial tools for examining complex systems, recently. The purpose of this paper is to demonstrate an automated coupling of a CFD program with a commercial thermal radiation tool. Based on a previous work the coupling behaviour of a parallelized CFD code is being demonstrated. The automation thus speeds up the calculation procedure even for transient simulations not relying on codes of just one vendor. The simulation is then compared with measurements of temperatures of an actual SUV and conclusions are drawn.&lt;/div&gt;
Evidence for the natural transmission of influenza A virus from wild ducts to swine and its potential importance for man. (1981)

In 1979, epidemics of influenza occurred in pigs in Belgium from which were isolated strains of influenza A (Hsw1N1) virus antigenically closely related to Hsw1N1 strains previously isolated from ducks in North America and the Federal Republic of Germany. This finding is considered as the first supportive evidence that an influenza A virus in an avian species might have been transmitted to mammals.
Some fundamental aspects of self-levitating sliding contact bearings and their practical implementations (2014)

In this study, fundamental aspects and mechanisms of acoustic levitation together with governing equations are presented first. Then, the acoustic levitation phenomenon is considered as a new way to design air suspension systems capable of self-levitation. A particular emphasis is laid on journal bearings and their specific geometrical configuration. A practical feasibility of using acoustic levitation to separate contacting surfaces is supported and illustrated by results of experimental testing of a number of prototype devices.
Bridging fault diagnosis in the absence of physical information (2002)

Effective bridging fault diagnosis requires reducing the (/sub 2//sup n/) number of bridging faults to a handful of candidates. A preliminary step can reduce the O(n/sup 2/) candidates to a manageable O(n) candidates by using layout information to eliminate those bridging faults that are very unlikely to be shorted together. This step removes from consideration those faults that match the fault signature but are physically impossible. However, sometimes-perhaps due to issues of intellectual property or because the degree of information stored about a circuit changes over its lifecycle-the physical design of the circuit is not available, and the number of nodes is too large to explicitly consider all pairs. In this paper we present two ways to provide successful diagnoses without access to physical information. The second method produces optimal diagnoses under our ranking criteria. Either technique can be used in conjunction with information extracted from the physical design to allow for diagnoses of much larger circuits than previously possible.
Higher CSF Ab38 levels protect against cognitive decline in high‐functioning individuals (2022)

Abstract Background The amyloid cascade hypothesis proposes that Alzheimer’s disease (AD) pathology starts with accumulation of b‐amyloid (Ab) peptides, leading to plaque deposition. In this context, the spotlight has been pointed firmly onto Ab42, but evidence suggests that shorter isoforms may also play an important role in modulating AD pathophysiology. A recent report with individuals with mild cognitive impairment or subjective cognitive decline (Cullen et al., 2021) has shown that higher cerebrospinal fluid (CSF) levels of Ab38 were associated with less decline on the mini‐mental state exam (MMSE) score and reduced risk of conversion to AD. The aim of this study was to test whether CSF Ab38 levels also predicted change in MMSE scores in cognitively intact individuals. Method Data were obtained from 40 individuals (age = 67.3, 6.3), who had taken part in a study on late‐life major depressive disorder at the Nathan Kline Institute and New York University. Data were available for baseline examination as well as three‐year follow up. Twenty‐three individuals were depressed at baseline, and 17 were controls; all had an MMSE score of 28 or higher at baseline. To test our hypothesis, we carried out a Bayesian linear regression analysis with change in MMSE score from baseline to follow‐up as outcome; CSF Ab38, CSF Ab42, and CSF phosphorylated (p) tau as predictors; and controlling for age, sex, APOE e4‐status and depression diagnosis (null model). Result The results showed that the model combining CSF Ab38 and CSF p tau was the strongest, with moderate evidence (BFm = 4), carrying nearly double the odds of the model with all predictors (BF 10 = 0.539), and 4.6 times the odds of the null model (BF 10 = 0.219): higher baseline levels of CSF Ab38 were associated with less decline in MMSE score, while higher p tau levels were linked to more decline. When isolating depressed individuals, the pattern of results was unchanged, while the null model was strongest with controls. Conclusion These findings confirm the importance of examining shorter Ab isoforms also in individuals with no cognitive impairment or subjective cognitive decline.
Neural Stem Cell Detection, Characterization, and Age-Related Changes in the Subventricular Zone of Mice (2004)

The mammalian brain contains neural stem cells (NSCs) that allow continued neurogenesis throughout the life of the animal. However, neurogenesis is known to decline during aging and, to the extent that neurogenesis is required for normal CNS function, this may contribute to neurodegenerative disease. Decreased neurogenesis could result from loss of NSCs or dysfunction at some later step, and distinguishing these possibilities is important for understanding the cause of the decline. However, because of the inability to distinguish NSCs from their rapidly dividing progeny in situ, it has not been possible to quantitatively assess the NSC populations in young and old animals. In this report we show that the G1 phase-specific expression of the replication factor Mcm2 is a useful marker for detecting slowly cycling putative NSCs in situ and confirm the identity of these cells using both cytosine beta-D-arabinofuranoside (Ara-C) treatment and a double nucleoside analog-labeling technique. The ability to distinguish NSCs from proliferative progenitors has allowed characterization of the expression of several markers including Nestin, Musashi, and GFAP in these different cell types. Furthermore, comparison of the NSC populations in the subventricular zones of young (2-4 months) and old (24-26 months) mice demonstrates an approximately twofold reduction in the older mice. A similar twofold reduction is also observed in the number of neurospheres recovered in culture from old relative to young animals. The reduction in the neural stem cell population documented here is sufficient to account for the reduced level of neurogenesis in old animals.
Determinants of antigenic molecules responsible for genetically controlled regulation of immune responses. (1976)

The ability of mice bearing the H-2S haplotype to develop helper responses to the random copolymer of Glu,Ala while they developed suppressor responses to the terpolymer of Glu,Ala,Tyr suggested the crucial role of tyrosine in these peptides. On the basis of various considerations, it was postulated that many of the tyrosine residues in Glu,Ala,Tyr would be localized at the NH2-terminal end of the molecule. To verify this hypothesis, a block terpolymer composed of a short sequence of homopolymer tyrosine covalently bound to the random copolymer of Glu,Ala was synthesized. The present studies, using this block terpolymer, demonstrated that the chemical determinants stimulating helper and suppressor responses are distinct and can be present simultaneously in the same molecule. Thus, addition of COOH-terminal tyrosine residues to the Glu,Ala polypeptide converted this immunogenic molecule to an immunosuppressive molecule in mice bearing the H-2S haplotype. The mechanism by which these short sequences of tyrosine influence H-2-linked immune responses remains to be determined.
Right Ventricular Expression of NT-proBNP Adds Predictive Value to REVEAL Score in Patients with Pulmonary Arterial Hypertension (2021)

Right ventricular NT-proBNP levels combined with REVEAL 2.0 could predict the development of subsequent HF in patients with PAH and may be a potential biomarker.
Effect of central CO2 drive on lung inflation responses of expiratory bulbospinal neurons in dogs (2000)

The purpose of these studies is to better understand the nature of the reflex interactions that control the discharge patterns of caudal medullary, expiratory (E) bulbospinal neurons. We examined the effect of central chemodrive inputs measured as arterial CO(2) tension (Pa(CO(2))) during hyperoxia on the excitatory and inhibitory components of the lung inflation responses of these neurons in thiopental sodium-anesthetized, paralyzed dogs. Data from slow ramp inflation and deflation test patterns, which were separated by several control inflation cycles, were used to produce plots of neuronal discharge frequency (F(n)) versus transpulmonary pressure (P(t)). P(t) was used as an index of the activity arising from the slowly adapting pulmonary stretch receptors (PSRs). Changes in inspired CO(2) concentrations were used to produce Pa(CO(2)) levels that ranged from 20 to 80 mmHg. The data obtained from 41 E neurons were used to derive an empirical model that quantifies the average relationship for F(n) versus both P(t) and Pa(CO(2)). This model can be used to predict the time course and magnitude of E neuronal responses to these inputs. These data suggest that the interaction between Pa(CO(2)) and PSR-mediated excitation and inhibition of F(n) is mainly additive, but synergism between Pa(CO(2)) and excitatory inputs is also present. The implications of these findings are discussed.
Partial sequence of the GDP-mannose dehydrogenase gene from Azotobacter vinelandii (1994)

Conference Article| August 01 1994 Partial sequence of the GDP-mannose dehydrogenase gene from Azotobacter vinelandii STAVROULA KOUSTENI; STAVROULA KOUSTENI 1Department of Biochemistry, University of Wales, Cardiff, P.O. Box 903, Cardiff, CF1 1ST, U.K. Search for other works by this author on: This Site PubMed Google Scholar PETER GACESA PETER GACESA 1Department of Biochemistry, University of Wales, Cardiff, P.O. Box 903, Cardiff, CF1 1ST, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1994) 22 (3): 357S. https://doi.org/10.1042/bst022357s Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation STAVROULA KOUSTENI, PETER GACESA; Partial sequence of the GDP-mannose dehydrogenase gene from Azotobacter vinelandii. Biochem Soc Trans 1 August 1994; 22 (3): 357S. doi: https://doi.org/10.1042/bst022357s Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1994 Biochemical Society1994 Article PDF first page preview Close Modal You do not currently have access to this content.
Investigation of Non-Radiative Processes in InAs/(Ga,In)(N,As) Quantum Dots (2007)

International audience
Spontaneous pathology of the baboon endocrine system (2009)

Endocrine disease in baboons is common and shares clinical and biochemical characteristics with endocrine disease in humans.