gebhart/patrepeval huggingface dataset:
A 0.5μm SiGe pre-equalizer for 10Gb/s single-mode fiber optic links (2005)

A 10-complex-tap T/2-spaced pre-equalizer, intended to equalize a 10 Gb/s duobinary signal transmitted over 400 km of standard single-mode fiber, is described. Fabricated in 47 GHz f/sub T/ SiGe technology, it operates at clock frequencies up to 13 GHz (limited by test equipment), occupies an area of 3.9/spl times/3.2 mm/sup 2/, and dissipates 3 W from a dual supply of 5 V and 3.3 V.
Kinetics of Complexation Reactions at Surfaces and in Solution: Implications for Enhanced Radionuclide Migration (1994)

Article Kinetics of Complexation Reactions at Surfaces and in Solution: Implications for Enhanced Radionuclide Migration was published on December 1, 1994 in the journal Radiochimica Acta (volume 66-67, issue Supplement).
Assessment of DNA contents of soil fungi (2008)

DNA extractions from microorganisms under soil condi- tions have been published to a great extent during the lastdecade.� Aquantitationalapproachwas,� however,� rarely attempted so that until today there is hardly a data source available which gives information on DNA contents of microorganisms, i.e. fungi, on a dry weight basis. This is however a very necessary aspect, particularly when an extractionprotocolperseshouldbetestedforitsefficacy� or particularly as well in ecological studies, where it would be important to have an unbiased extraction procedure. That is, the procedure used should be optimal for DNA extraction of both bacteria and fungi to the same extent. Sincethemajorityofextractionprotocolsusedtodaywere� designed to extract DNA from bacteria, it was found nec- essarytoexamineourownextractionprocedure�(Blago- datskayaet.al.,�2003)�foritsapplicabilitytoextractDNA� from soil fungi. DNA extractions from 25 soil fungal species resulted in a mean dsDNA recovery of 3.3 µg mg -1 dry weight with a range of 0.92 µg mg -1 to 6.32 µg mg -1 . However, a modificationoftheoriginalextractionprocedurebyomit- tingaurintricarboxylicacid�(ATA)�butaddingaGlucanex- lyticase enzyme complex which was tested on ten fungal species resulted in a doubling of dsDNA yields with a mean of 6.45 µg mg -1 �dryweight�(range�4.2�µgmg -1 �to�8.7�µg� mg -1 dry weight), whereby eight of the ten species gave DNA yields above 6.0 µg mg -1 dry weight, which indicates
SD-PUF: Spliced Digital Physical Unclonable Function (2017)

Digital circuit physical unclonable function (PUF) has been attracting attentions for the merits of resilience to the environmental and operational variations that analog PUFs suffer from. Existing state-of-the-art digital circuit PUFs, however, are either hybrid of analog-digital circuits which are still under the shadow of vulnerability, or impractical for real-world applications. In this paper, we propose a novel highly nonlinear and secure digital PUF (D-PUF) and the spliced version SD-PUF. The fingerprints are extracted from intentionally induced very large-scale integration interconnect randomness during lithography process, as well as a post-silicon shuffling process. Strongly skewed CMOS latches are used to ensure the immunity against environmental and operational variations. Crucially, a highly nonlinear logic network is proposed to effectively spread and augment any subtle interconnect randomness, which also enables strong resilience against machine learning attacks. On top of it, the expandable architecture of the proposed logic network empowers a novel post-silicon shuffle-splice mechanism, where multiple randomly selected D-PUFs are spliced to be one SD-PUF, pushing the statistical security to a much higher level, while significantly reducing the mask cost per PUF device. It also decouples the trustworthy demands enforced to the foundries or other third party manufacturers. Our proposed PUFs demonstrate close to ideal performance in terms of statistical metrics, including 0 intra-Hamming distance. Various state-of-the-art machine learning models show prediction accuracies almost no better than random guesses when attacking to the proposed PUFs. We also mathematically prove the probability of existence of identical SD-PUF pair is significantly lower than that of D-PUF pair, e.g., such probability of an SD-PUF spliced by 30 D-PUFs is 2.3 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-22</sup> , which is 19 order magnitude lower than that of D-PUF. Benefited from the proposed shuffle-splice mechanism, the mask cost per SD-PUF is also reduced by 300× than that of D-PUF.
TP53 intron 1 hotspot rearrangements are specific to sporadic osteosarcoma and can cause Li-Fraumeni syndrome (2015)

Somatic mutations of TP53 are among the most common in cancer and germline mutations of TP53 (usually missense) can cause Li-Fraumeni syndrome (LFS). Recently, recurrent genomic rearrangements in intron 1 of TP53 have been described in osteosarcoma (OS), a highly malignant neoplasm of bone belonging to the spectrum of LFS tumors. Using whole-genome sequencing of OS, we found features of TP53 intron 1 rearrangements suggesting a unique mechanism correlated with transcription. Screening of 288 OS and 1,090 tumors of other types revealed evidence for TP53 rearrangements in 46 (16%) OS, while none were detected in other tumor types, indicating this rearrangement to be highly specific to OS. We revisited a four-generation LFS family where no TP53 mutation had been identified and found a 445 kb inversion spanning from the TP53 intron 1 towards the centromere. The inversion segregated with tumors in the LFS family. Cancers in this family had loss of heterozygosity, retaining the rearranged allele and resulting in TP53 expression loss. In conclusion, intron 1 rearrangements cause p53-driven malignancies by both germline and somatic mechanisms and provide an important mechanism of TP53 inactivation in LFS, which might in part explain the diagnostic gap of formerly classified "TP53 wild-type" LFS.
Supplementary Figure 1A from Depletion of Peripheral Macrophages and Brain Microglia Increases Brain Tumor Titers of Oncolytic Viruses (2023)

Supplementary Figure 1A from Depletion of Peripheral Macrophages and Brain Microglia Increases Brain Tumor Titers of Oncolytic Viruses
Feldeffekttransistoren als Sensoren (1990)

Abstract Der Einsatz ionensensitiver Feldeffekttransistoren als chemische Sensoren könnte viele in Medizin und Umweltschutz bedeutsame Nachweisverfahren optimieren helfen.
Reformas neoliberais no Peru:crise do Estado, privatizações e autoritarismo político (1990/2000) (2017)

A partir do final da década de 1970, o neoliberalismo passou a ser adotado como modelo de desenvolvimento econômico por diversos países do capitalismo avançado. Durante a década de 1990, contudo, este modelo viria a ser seguido pelos governos do capitalismo periférico, incluindo aqueles historicamente identificados com as esquerdas, sobretudo na América Latina. Este artigo tem como objetivo discutir as principais reformas neoliberais implementadas no Peru durante o governo Alberto Fujimori (1990/2000). A hipótese aqui defendida é de que o processo de implantação do receituário neoliberal, defendido pelo Consenso de Washington, resultou em um profundo processo de desmantelamento do regime democrático-constitucional, conduzindo à instauração de um regime autoritário, com apoio das Forças Armadas, em que predominou a corrupção e o terrorismo de Estado.
Demonstration of mucosa-associated microbial populations in the colons of mice (1987)

Gram-stained sections prepared in a microtome-cryostat and examined by light microscopy confirmed the observation with scanning electron microscopy made by other workers that microbes inhabit a zone adjacent to the mucosal surface of the proximal colon of mice. Microbes in the midcolon, in contrast, are restricted to the fecal pellets occupying the intestinal lumen.
Supporting event based traceability through high-level recognition of change events (2003)

Although requirements traceability is crucial in both the development and maintenance of a software system, traceability links and related artifacts tend to deteriorate, as time-pressured practitioners fail to systematically update them in response to change. Event-based traceability addresses this issue by establishing links through a loosely coupled publisher/subscriber scheme. Dependent entities subscribe to requirements and receive event notifications as changes occur. This paper focuses upon the role played by the requirements specification as a publisher of events. A set of standard change events is defined and a method for monitoring a user's actions within a requirements management environment and the subsequent recognition and publication of the change events is proposed. Early results obtained from testing this approach are reported.
Conformational study of a series of somatostatin analogues with antitumor and/or GH inhibitory activity (1994)

A series of somatostatin analogues with varying activities have been studied by 1H NMR in CD3OH at low temperature in order to find a possible structural explanation for the differentiation of biological activities. In somatostatin analogues with GH release inhibitory activity a beta-turn/beta-sheet backbone conformation is present, which is shown to be characteristic of somatostatin-derived peptides exhibiting this biological activity. On the other hand, among the analogues with antitumor activity, a deviation from these typical structural features is clearly observed, but not general conformational model can be proposed.
Towards Occlusion-Free Surgical Instrument Tracking: A Modular Monocular Approach and an Agile Calibration Method (2015)

Optical means of instrument tracking has been widely used in image-guided interventions and considered the de facto standard for tracking rigid bodies with a direct line-of-sight. However, the occlusion problem which remains unresolved in current systems frustrates surgeons during the operation. To address this challenge, we propose a surgical instrument tracking system based on multiple reconfigurable monocular modules. The main approach is to enable the system to dynamically reconfigure the multiple monocular modules when occlusion occurs partially within the workspace. In this paper, we focus on the system architecture and an agile multicamera calibration method which only uses the customized tool for the surgical instrument tracking scenario. Additionally, two fast non-iterative algorithms are proposed and studied. In order to show the feasibility and superiority of the corresponding multicamera calibration algorithm, comparison experiments have carried out. The intensive investigation results give a practical instruction to the real implementation of the proposed system in image-guided interventions.
A note on robustness bounds for large-scale time-delay systems (1995)

Abstract A stability criterion for large-scale time-delay systems with unstructured uncertainties is derived by making use of the concept of Razumikhin. The uncertainties may be linear, nonlinear and/or time-varying.
RNA-binding protein immunoprecipitation as a tool to investigate plant miRNA processing interference by regulatory proteins of diverse origin (2018)

The RIP method described here provides a reliable tool to study the interaction of RBPs, such as transiently expressed regulatory proteins with lowly represented host RNA, as is the case of miRNA precursors. This modified method was efficiently adjusted to recover nuclear proteins and reduce unspecific background. The purification scheme optimized here for GFP-tagged proteins can be applied to a wide array of RBPs. The subsequent application of next-generation sequencing technologies will permit to sequence and characterize all RNA species bound in vivo by a given RBP.
ADAMTS13 gene defects in two brothers with constitutional thrombotic thrombocytopenic purpura and normalization of von Willebrand factor‐cleaving protease activity by recombinant human ADAMTS13 (2003)

Genetic analysis of the ADAMTS13 locus identified six mutations in the ADAMTS13 genes of two brothers suffering from constitutional thrombotic thrombocytopenic purpura (TTP): a stop codon leading to a truncated protein on the paternal ADAMTS13 allele and five amino acid exchanges on the maternal allele, three of which were single nucleotide polymorphisms. The other two mutations, not detected in 230 sequenced alleles of healthy control subjects, are, therefore, probably responsible, alone or as part of a combination, for the severe ADAMTS13 deficiency. We also investigated the feasibility of using recombinant ADAMTS13 (rADAMTS13) for normalization of von Willebrand factor-cleaving protease (VWF-cp) activity in plasma of the two congenitally deficient patients. Addition of rADAMTS13 to their plasma restored the VWF-processing pattern to normal, suggesting the potential usefulness of rADAMTS13 for therapy and prophylaxis of familial TTP.
A multiscale model of adaptation and spatial vision for realistic image display (1998)

In this paper we develop a computational model of adaptation and spatial vision for realistic tone reproduction. The model is based on a multiscale representation of pattern, luminance, and color processing in the human visual system. We incorporate the model into a tone reproduction operator that maps the vast ranges of radiances found in real and synthetic scenes into the small fixed ranges available on conventional display devices such as CRT’s and printers. The model allows the operator to address the two major problems in realistic tone reproduction: wide absolute range and high dynamic range scenes can be displayed; and the displayed images match our perceptions of the scenes at both threshold and suprathreshold levels to the degree possible given a particular display device. Although in this paper we apply our visual model to the tone reproduction problem, the model is general and can be usefully applied to image quality metrics, image compression methods, and perceptually-based image synthesis algorithms. CR Categories: I.3.0 [Computer Graphics]: General;
Phylogenetic information improves homology detection (2001)

We present a database search method that is based on phylogenetic trees (treesearch). The method is used to search a protein sequence database for homologs to a protein family. In preparation for the search, a phylogenetic tree is constructed from a given multiple alignment of the family. During the search, each database sequence is temporarily inserted into the tree, thus adding a new edge to the tree. Homology between family and sequence is then judged from the length of this edge. In a comparison of our method to profiles (ISREC pfsearch), two implementations of hidden Markov models (HMMER hmmsearch and SAM hmmscore), and to the family pairwise search (FPS) method on 43 families from the SCOP database based on minimum false-positive counts (min-FPCs), we found a considerable gain in sensitivity. In 69% of the test cases, treesearch showed a min-FPC of at most 50, whereas the two second best methods (hmmsearch and FPS) showed this performance only in 53% cases. A similar impression holds for a large range of min-FPC thresholds. The results demonstrate that phylogenetic information can significantly improve the detection of distant homologies and justify our method as a useful alternative to existing methods.
Network control by Bayesian broadcast (1987)

A transmission control strategy is described for slotted-ALOHA-type broadcast channels with ternary feedback. At each time slot, each station estimates the probability that n stations are ready to transmit a packet for each <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">n</tex> , using Bayes' rule and the observed history of collisions, successful transmissions, and holes (empty slots). A station transmits a packet in a probabilistic manner based on these estimates. This strategy is called Bayesian broadcast. An elegant and very practical strategy--pseudo-Bayesian broadcast--is then derived by approximating the probability estimates with a Poisson distribution with mean <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\nu</tex> and further simplifying. Each station keeps a copy of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\nu</tex> , transmits a packet with probability <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1/\nu</tex> , and then updates <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\nu</tex> in two steps: For collisions, increment <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\nu</tex> by <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">(e-2)^{-l}=1.39221 \cdots</tex> . For successes and holes, decrement <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\nu</tex> by <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</tex> . Set <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\nu</tex> to <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\max (\nu + \hat{\lambda}, 1)</tex> , where <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\hat{\lambda}</tex> is an estimate of the arrival rate <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\lambda</tex> of new packets into the system. Simulation results are presented showing that pseudo-Bayesian broadcast performs well in practice, and methods that can be used to prove that certain versions of pseudo-Bayesian broadcast are stable for <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">\lambda &lt; e^{-1}</tex> are discussed.
Preparation of Poly(lactic acid) Microspheres Containing Anti-cancer Drugs (Commemoration Issue Dedicated to Professor Hiroshi Ibagaki, Professor Michio Kurata, Professor Ryozo Kitamura, On the Occasion of Their Retirments) (1989)

Biodegradable poly(L-lactic acid) and poly(D, L-lactic acid) microspheres incorporating anti-cancer drugs, adriamycin and cisplatin, were prepared by the solvent evaporation method.Effects of several variables on the drug release were studied and it was found that the drug distribution in the matrix was the most important, which in turn depended on the solubility of the drug in the matrix polymer.Release rates of the drug could be altered to some extents by changing the drug loading, the molecular.weight and chemical composition of the matrix polymer, and the drug/polymer mixing method.Especially, the mechanical mixing could greatly reduce the drug burst seen in an early stage of the release.KEY WORDS: Poly(lactic acid)
Cooling a Magnetic Nanoisland by Spin-Polarized Currents (2014)

We investigate cooling of a vibrational mode of a magnetic quantum dot by a spin-polarized tunneling charge current exploiting the magnetomechanical coupling. The spin-polarized current polarizes the magnetic nanoisland, thereby lowering its magnetic energy. At the same time, Ohmic heating increases the vibrational energy. A small magnetomechanical coupling then permits us to remove energy from the vibrational motion and cooling is possible. We find a reduction of the vibrational energy below 50% of its equilibrium value. The lowest vibration temperature is achieved for a weak electron-vibration coupling and a comparable magnetomechanical coupling. The cooling rate increases at first with the magnetomechanical coupling and then saturates.
Comparative Genomics and Experimental Characterization of N-Acetylglucosamine Utilization Pathway of Shewanella oneidensis (2006)

We used a comparative genomics approach implemented in the SEED annotation environment to reconstruct the chitin and GlcNAc utilization subsystem and regulatory network in most proteobacteria, including 11 species of Shewanella with completely sequenced genomes. Comparative analysis of candidate regulatory sites allowed us to characterize three different GlcNAc-specific regulons, NagC, NagR, and NagQ, in various proteobacteria and to tentatively assign a number of novel genes with specific functional roles, in particular new GlcNAc-related transport systems, to this subsystem. Genes SO3506 and SO3507, originally annotated as hypothetical in Shewanella oneidensis MR-1, were suggested to encode novel variants of GlcN-6-P deaminase and GlcNAc kinase, respectively. Reconstitution of the GlcNAc catabolic pathway in vitro using these purified recombinant proteins and GlcNAc-6-P deacetylase (SO3505) validated the entire pathway. Kinetic characterization of GlcN-6-P deaminase demonstrated that it is the subject of allosteric activation by GlcNAc-6-P. Consistent with genomic data, all tested Shewanella strains except S. frigidimarina, which lacked representative genes for the GlcNAc metabolism, were capable of utilizing GlcNAc as the sole source of carbon and energy. This study expands the range of carbon substrates utilized by Shewanella spp., unambiguously identifies several genes involved in chitin metabolism, and describes a novel variant of the classical three-step biochemical conversion of GlcNAc to fructose 6-phosphate first described in Escherichia coli.
MPSS (2010)

This article describes MPSS, a new way to do proactive secret sharing. MPSS provides mobility : The group of nodes holding the shares of the secret can change at each resharing, which is essential in a long-lived system. MPSS additionally allows the number of tolerated faulty shareholders to change when the secret is moved so that the system can tolerate more (or fewer) corruptions; this allows reconfiguration on-the-fly to accommodate changes in the environment. MPSS includes an efficient protocol that is intended to be used in practice. The protocol is optimized for the common case of no or few failures, but degradation when there are more failures is modest. MPSS contains a step in which nodes accuse proposals made by other nodes; we show a novel way to handle these accusations when their verity cannot be known. We also present a way to produce accusations that can be verified without releasing keys of other nodes; verifiable accusations improve the performance of MPSS, and are a useful primitive independent of MPSS.
Cooperative model for the binding of Xenopus transcription factor A to the 5S RNA gene. (1983)

7S particles containing 5S RNA and the transcription regulatory protein factor A have been purified to near homogeneity from Xenopus laevis oocytes. The binding of the transcription factor to the Xenopus borealis somatic 5S RNA gene has been monitored by quantitating the DNase I protection patterns of the protein-DNA interaction. Under stoichiometric binding conditions--i.e., when all added DNA binds to the factor--two protein molecules are required to saturate the 5S RNA gene. Under equilibrium binding conditions, titration of the 5S RNA gene with factor A results in a sigmoidal binding isotherm suggesting a cooperative interaction; half-saturation of binding is observed at a free factor A concentration of 1 nM. Cooperative binding between factor A and the 5S RNA gene may contribute to the stability of the transcription apparatus and its maintenance during cell division.