gebhart/patrepeval huggingface dataset:
Gastrointestinal Hormone in Dumping Syndrome and Reflux Esophagitis after Gastric Surgery. (1997)

Several problems are associated with gastric resection, including the dumping syndrome, reflux esophagitis, and malabsorption. A better understanding of the pathophysiological changes will shed light on new and improved therapy. Serum levels of seven circulating gastrointestinal hormones following a standardized solid meal and a brief score of symptoms were evaluated in 10 patients after partial distal gastrectomy and 12 patients after total gastrectomy, both groups reconstructed by Billroth II anastomosis, and 9 age-matched healthy controls. Patients underwent resection for gastric cancer and were studied 45 +/- 10 months after surgery. At the time of study, the patients had adapted well to surgery and no longer exhibited the severe symptoms of dumping seen immediately post-operatively. In contrast, the total gastrectomy patients exhibited the symptoms of reflux esophagitis. The gastrointestinal hormone changes could be divided into three patterns; obtunded responses (gastrin, PP), normal release (motilin, GIP) and increased secretion (CCK, neurotensin, PYY). In these, the early reaction of neurotensin correlated with the scores of late dumping syndrome and reflux esophagitis. In the literature, many gastrointestinal hormones have been shown to respond as an enhancement rather than adaptation. In other gastrointestinal hormones, secretin belonged to the obtunded type and enteroglucagon were classified in the increased type. However, pathophysiological significance of these hormonal changes remained uncertain. The late adaptive changes in gastrointestinal hormone secretion may help to compensate for loss of gastric motor function which accompanies gastric resection. On the other hand, these hormonal changes may exacerbate the esophageal reflux following gastrectomy.
A Importância do Psicólogo na Vidade do Paciente Oncológico desde o Diagnóstico até a fase Terminal (2018)

INTRODUCAO: O câncer e uma doenca que se origina nos genes de uma unica celula, onde se e caracterizado pelo seu crescimento desordenado e anormal, dessa forma podendo espalhar-se ate formar uma massa tumoral. A psico-oncologia permite a interacao entre psicologia e a oncologia, onde sao abordadas diversas questoes desde o adoecimento desenvolvido pelo câncer ate os problemas psicossociais. OBJETIVO: Discutir a importância do psicologo na vida do paciente oncologico nas diversas fases por ele vivenciadas. METODOLOGIA: O presente trabalho foi realizado na forma de revisao da literatura. RESULTADOS: A literatura investigada mostrou que o paciente diagnosticado com câncer passa por diversos estagios que incluem a negacao, a raiva, a barganha, a depressao e a aceitacao. Em cada periodo vivenciado, o sofrimento se evidencia de forma concreta na vida do individuo que precisa de ajuda de outrem para enfrentar os desafios que se lhe impoem. Levando em consideracao aos aspectos apresentados, e imprescindivel que um psicologo auxilie o paciente a vivenciar cada fase de seu adoecimento, desde o diagnostico ate a fase terminal, dando auxilio aos familiares e acompanhantes de cada um deles. O profissional deve buscar sempre levar a compreensao, sem realizar julgamento de suas crencas e de sua fe, procurando respeitar a espiritualidade do individuo adoecido hospitalizado e entender como o câncer modifica a forma de enxergar o mundo a sua volta. CONSIDERACOES FINAIS: Considera-se ser de grande relevância a atuacao do psicologo junto ao paciente oncologico independente da fase em que esse se encontra.
Frictional Phenomena. X (1942)

THE application of the viscosity concept to this technically important field is presented. Discussed first is film lubrication which occurs when the film thickness is greater than 10−5 cm. This mechanism is chiefly controlled by the viscosity η of the liquid. The basic mathematical theory is developed, and it is shown how this adequately describes the experimental facts. Next boundary lubrication is discussed, a type occurring with stable layers less than 10−5 cm thick. This mechanism is essentially a plastic flow within the boundary layer. The chief experimental data are described together with their technical implications.
Development of Membrane Bioreactor for Industrial Production of Optically Active 3-Phenylglycidic Acid Ester. (1996)

An optically active (2R, 3S) -3- (4-methoxyphenyl) glycidic acid methyl ester ((-) MPGM) was an important intermediate for the synthesis of diltiazem hydrochloride which is a typical calcium channel blocker. To establish a practical production system of this useful chiral compound, a hollow-fiber ultrafiltration membrane bioreactor has been developed. In the bioreactor system, the lipase from Serratia marcescens was immobilized on the spongy layer of the shell side of a membrane by means of physical adsorption. Asymmetric hydrolysis was carried out semi-continuously in a membrane bioreactor circulating both toluence solution containing racemate ((±) MPGM) in the shell loop and aqueous solution cotaining NaHSO3 in the lumen loop. The membrane bioreactor permitting the simultaneous achievement of enzyme reaction and phase separation was highly efficient for industrial production of (-) MPGM. This paper briefly describes the process of research development of the industrial-scale membrane bioreactor. In addition, our recent works relating to membrane bioreactors were presented.
Dual source CT (DSCT) imaging of obese patients: evaluation of CT number accuracy, uniformity, and noise (2009)

Obese patients present challenges in obtaining sufficient x-ray exposure over reasonable time periods for acceptable CT image quality. To overcome this limitation, the exposure can be divided between two x-ray sources using a dualsource (DS) CT system. However, cross-scatter issues in DS CT may also compromise image quality. We evaluated a DS CT system optimized for imaging obese patients, comparing the CT number accuracy and uniformity to the same images obtained with a single-source (SS) acquisition. The imaging modes were compared using both solid cylindrical PMMA phantoms and a semi-anthropomorphic thorax phantom fitted with extension rings to simulate different size patients. Clinical protocols were used and CTDIvol and kVp were held constant between SS and DS modes. Results demonstrated good agreement in CT number between SS and DS modes in CT number, with the DS mode showing better axial uniformity for the largest phantoms.
Inhibition of the human chemokine receptor CXCR4 by antisense phosphorothioate oligodeoxyribonucleotides (2001)

The CXC chemokine receptor CXCR4/fusion, a major coreceptor for the T-cell line T-tropic (X4) HIV-1 virus, plays a critical role in T-tropic virus fusion and entry into permissive cells. In the present study, we describe the effects of an antisense phosphorothioate oligodeoxyribonucleotide (anti-S-ODN) on the inhibition of CXCR4 gene expression in X4 HIV-1 infected HeLa-CD4 cells, to find more efficacious therapeutic possibilities for human immunodeficiency virus type 1 (HIV-1) infection. The naked antisense phosphorothioate oligodeoxyribonucleotide (anti-S-ODN-1), containing the AUG initiation codon at the center of the oligodeoxyribonucleotide, showed a slightly higher inhibitory effect on HIV-1 gag p24 production among all sequences tested. We also examined the concomitant use of a basic peptide transfection reagent, nucleosomal histone proteins (RNP), for the delivery of the anti-S-ODN-1. The anti-S-ODN-1 encapsulated with RNP had higher inhibitory effects on p24 products than the naked anti-S-ODN-1. When the anti-S-ODN-1 encapsulated with RNP was incubated with HeLa-CD4 cells, the surface levels of this chemokine receptor showed high suppression, indicating sequence-specific inhibition. The activities of unmodified oligodeoxyribonucleotide are effectively enhanced by using a basic peptide, RNP.
Herding Cats - Modelling, simulation, testing, and data-mining for weak memory (2013)

We propose an axiomatic generic framework for modelling weak memory. We show how to instantiate this framework for SC, TSO, C++ restricted to release-acquire atomics, and Power. For Power, we compare our model to a preceding operational model in which we found a flaw. To do so, we define an operational model that we show equivalent to our axiomatic model. We also propose a model for ARM. Our testing on this architecture revealed a behaviour later acknowledged as a bug by ARM, and more recently 33 additional anomalies. We offer a new simulation tool, called herd, which allows the user to specify the model of his choice in a concise way. Given a specification of a model, the tool becomes a simulator for that model. The tool relies on an axiomatic description; this choice allows us to outperform all previous simulation tools. Additionally, we confirm that verification time is vastly improved, in the case of bounded model-checking. Finally, we put our models in perspective, in the light of empirical data obtained by analysing the C and C++ code of a Debian Linux distribution. We present our new analysis tool, called mole, which explores a piece of code to find the weak memory idioms that it uses.
Comparison of Linear Prediction Methods in Terms of Sparsity, Stability and Robustness to Reverberation (2014)

The aim of this paper is to provide an experimental evaluation of five linear prediction methods in terms of sparsity, stability and robustness to reverberation. Moreover, we show that all the considered methods can be derived from a general linear prediction optimization problem. It is empirically found that the sparsest and also one of the most stable and robust to reverberation method is linear prediction based on L1 minimization combined with a double pre-emphasis of speech.
A critical evaluation of the application of capillary electrophoresis to the detection and determination of 1,4‐benzodiazepine tranquilizers in formulations and body materials (1998)

Studies of the capillary zone electrophoresis (CZE) and micellar electrokinetic capillary chromatography (MEKC) behaviour of 1,4-benzodiazepines have seen application in subject areas such as the development of pharmaceuticals, therapeutic drug monitoring and forensic toxicology. In the development of pharmaceuticals, pKa determinations by CZE can be used in preclinical studies whereas analytical data on the detection and determination of 1,4-benzodiazepines is of value primarily in raw material/formulation assay and in the analysis of body fluids in clinical studies. The capillary electrophoresis (CE) techniques, which generally have inferior limits of detection (LOD) to rival techniques such as gas chromatography (GC) and high-performance liquid chromatography (HPLC), are particularly applicable in forensic toxicology where reasonably high concentrations of these drugs can be encountered. It is anticipated that, with the interfacing of CZE and capillary electrochromatography (CEC) with mass spectrometry (MS) techniques, the excellent selectivity of CZE and particularly CEC will be effectively combined with the sensitivity of MS and the identification capabilities of tandem mass spectrometry (MS/MS) and MS hyphenated (MSn) techniques.
Use of the Dual-Screen Thru-Tubing Sand Control Method (1994)

ABSTRACT This paper will describe a new sand control method used in an area of Ecuador, South America where workover rigs are not readily available. Sand production had been significantly affecting maintenance costs on surface and downhole production equipment and had impacted performance of the downhole jet pump, subsequently causing a decrease in well production. By installing a small-diameter, sintered metal gravel-pack screen across the perforation interval and placing the gravel-pack sand with coiled tubing, the sand production was successfully controlled. The procedure and equipment used to perform this technique as well as post job data that provide results obtained will also be presented. Noteworthy advantages, such as recompletion without removal of the existing production completion string and without use of a workover rig, will also be discussed.
Coping with spurious radiation in binary black hole simulations (2019)

Spurious radiation in the initial data for binary black hole numerical simulations has been an issue of concern. The radiation affects the masses and spins of the black holes, modifying their orbital dynamics and thus potentially compromising the accuracy of templates used in gravitational wave analysis. Our study finds that spurious radiation effects are localized to the vicinity of the black holes. Using insights from single black hole simulations, we obtain fitting formulas to estimate the changes from spurious radiation on the mass and spin magnitude of the black holes in binary systems. We demonstrate how these fitting formulas could be used to adjust the initial masses and spin magnitudes of the black holes, so the resulting binary has the desired parameters after the spurious radiation has left the computational domain. A comparison of waveforms from raw simulations with those from simulations that have been adjusted for spurious radiation demonstrate that spurious radiation could have an appreciable effect on the templates for LIGO sources with SNRs above 30.
Vitamin D insufficiency and risk of paclitaxel-induced peripheral neuropathy. (2019)

e12027 Background: Peripheral neuropathy (PN) is a severe, dose-limiting toxicity of paclitaxel that occurs in up to 25% of patients and can lead to permanent loss of balance and manual dexterity. Due to the lack of effective strategies for PN prevention or treatment, there is a critical need to identify predictive risk factors for paclitaxel-induced PN. Vitamin insufficiencies are known risk factors for PN in other disease states. However, the effect of vitamin insufficiency on paclitaxel-induced PN has not been adequately investigated. Methods: Baseline levels of vitamin D and other nutrients (vitamin B, homocysteine, folate) were measured, and PN was assessed weekly in an observational trial of patients receiving paclitaxel 80 mg/m 2 for 12 weeks for non-metastatic breast cancer (NCT0233811). Nutrient levels were measured by Michigan Medicine and insufficiency defined by institutional standards (vitamin D insufficiency &lt; 20 ng/mL). In the primary analysis, the maximum increase from baseline in the 8-item sensory subscale (ΔCIPN8) of the EORTC CIPN20, a validated patient-reported PN assessment tool, was compared in nutrient insufficient and sufficient patients. The effect of vitamin insufficiencies on PN-induced treatment disruptions (dose decrease, delay, or discontinuation) was conducted as a secondary analysis. Results: Only vitamin D insufficiency was identified in enough patients for analysis (15/37 = 41%). Vitamin D insufficient patients reported a greater mean (+/- SD) ΔCIPN8 (36.39 ±22.8) than vitamin D sufficient patients (16.29 ±16.3) (p = 0.003). However, the increase in treatment disruption for vitamin D insufficient patients was not significant (OR = 2.98, 95% CI [0.72, 12.34], p = 0.16). Conclusions: Paclitaxel-treated patients who were vitamin D insufficient at baseline had greater increases in patient-reported PN. If validated in larger studies, vitamin D insufficiency may be a clinically translatable, modifiable risk factor that can be used to prevent paclitaxel-induced PN in patients with non-metastatic breast cancer.
Genetic algorithm for ion thruster grid design (2007)

A genetic algorithm was used to optimize ion thruster grid sets with regard to maximizing impulse per unit area, essentially equivalent to maximizing propellant throughput capability per unit area. The genetic algorithm presented herein made use of the ffx ion optics simulation code for grid lifetime predictions. Grid sets were optimized for several combinations of net accelerating voltage and current density, and grid feature recommendations are made concerning how future missions can be met.
Iterative time-reversal control for inverse problems (2008)

A novel method to solve inverse problems for the wave equation is introduced. The method is a combination of the boundary control method and an iterative time reversal scheme, leading to adaptive imaging of coefficient functions of the wave equation using focusing waves in unknown medium. The approach is computationally effective since the iteration lets the medium do most of the processing of the data. <br>&nbsp; &nbsp The iterative time reversal scheme also gives an algorithm for approximating a given wave in a subset of the domain without knowing the coefficients of the wave equation.
Anwendung nuklearer Verfahren in der ungarischen Tonerdeindustrie (1979)

Der Beitrag gibt einen zusammenfassenden Überblick über die in der ungarischen Tonerdeindustric verwendeten nuklearen Versuchsmethoden. Anhand von Beispielen werden die an Betriebsapparaturen durchgeführten Durchlauf- und Verteiungsmessungen sowie die unter Laborbedingungen vorgenommenen reaktionskinetischen Untersuchungen, die auf die Klärung verschiedener Prozesse der Tonerdeherstellung gerichlet waren, veranschaulicht. Weiterhin werden analytische Anwendungen der Neutronenaktivierungs- und Röntgenfluoreszenzmethode sowie Meß- und Regelungseinrichtungen, die auf der Strahlenabsorption beruhen, bekanntgemacht.
Two-Scale Command Shaping for Reducing Powertrain Vibration During Engine Restart (2017)

This paper introduces a two-scale command shaping strategy for reducing vibrations in conventional and hybrid electric vehicle (HEV) powertrains during engine restart. The approach introduces no additional system components and thus few additional costs. The torque profile from an electric machine (EM) is tailored to start the internal combustion engine (ICE) while minimizing residual vibrations. It is shown that the tailored EM torque profile, composed of a linear combination of constant and time-varying components, results in significant mitigation of powertrain vibrations and smoother ICE startup. The time-varying EM torque component is calculated using an analytical ICE model and a perturbation technique for separating scales, which isolates the ICE nonlinear response. Command shaping is then applied to the linear problem at the remaining scale. Simulation results suggest a promising and straightforward technique for reducing vibrations and improving drivability during ICE restart. Furthermore, two-scale command shaping may also be useful in mitigating other HEV-related drivability issues associated with powertrain mode changes (e.g., blending of hybrid power sources, engaging and disengaging of clutches, etc.).
<title>Distributed multimedia data storage for dependability, scalability, and high performance</title> (1998)

In this paper, we describe a method for enabling efficient and dependable multimedia data storage and transfer in a large scale distributed computing and communication environment such as Web environment. The proposed method has several advantages over traditional ones: high data rates, scalability, availability, reliability, and seamless system controlled load balancing.
Lethal Effect of Phenothiazine Neuroleptics on the Pathogenic Protozoan Leishmania donovani (1982)

Phenothiazine drugs, which are widely used for their antipsychotic, antianxiety, and antiemetic effects, have been found to have protozoacidal effects on the human pathogen Leishmania donovani. These compounds are lethal to both the extracellular stage of the organism, which is inoculated into humans by the sand fly, and the intracellular stage, which is found solely in human macrophages during established infection.
Microwave Debye relaxation analysis of dissolved proteins: Towards free-solution biosensing (2011)

Aqueous solutions of a variety of proteins at different concentrations are examined through microwave spectroscopy and compared to sodium chloride and polystyrene nanospheres. The complex permittivity is analysed in terms of the Debye model and the Stokes-Einstein-Debye relation in conjunction with the Maxwell-Garnett equation. According to Einstein’s classical theory of viscosity with Brenner’s adaptation [H. Brenner, Chem. Eng. Sci. 27, 1069 (1972)] for arbitrary solute shapes, the ratio of the alterations of static permittivity and relaxation time of low concentration solutions is found to be independent of concentration and determined by the molecular shape. Our results represent a route towards free-solution identification through molecular finger-printing.
Cis double bonds in liquid crystalline bilayers (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCis double bonds in liquid crystalline bilayersFrancoise. Axel and Joachim. SeeligCite this: J. Am. Chem. Soc. 1973, 95, 24, 7972–7977Publication Date (Print):November 1, 1973Publication History Published online1 May 2002Published inissue 1 November 1973https://pubs.acs.org/doi/10.1021/ja00805a008https://doi.org/10.1021/ja00805a008research-articleACS PublicationsRequest reuse permissionsArticle Views44Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The topology of astrocyte networks controls the propagation of intercellular calcium waves (2014)

International audience
Preserving privacy while reducing power consumption and information loss in LBS and participatory sensing applications (2011)

Participatory sensing systems rely on the willingness of mobile users to participate in the collection and reporting of data using a variety of sensors either embedded or integrated in their cellular phones. Users agree to use their cellular phone resources to sense and transmit the data of interest because these data will be used to address a collective problem that otherwise would have been very difficult to solve. However, this new data collection paradigm has not been very successful yet mainly because of privacy concerns. Without adequate privacy-preserving mechanisms most users are not willing to participate. Although several schemes have been proposed in the literature, none of them offers a complete solution, and instead, trade offs exist. For example, anonymization-based schemes change the real location of the users, and therefore preserve their privacy, but they might not be precise enough for certain applications. On the other hand, encryption-based schemes, since they do not modify the real location of the user, are very accurate and serve well all applications; however, they are very costly in terms of energy consumption. In this paper we present a scheme that combines the good properties of both approaches to reduce the energy consumption of encryption-based schemes as well as the noise added by anonymization-based schemes. Our simulation results show that the proposed scheme in fact achieves the desired objectives of reducing the energy consumption and information loss while allowing the application to track the users accurately.