gebhart/patrepeval huggingface dataset:
Hypervalent iodine oxidation of p-alkoxyphenols and related compounds: a general route to p-benzoquinone monoacetals and spiro lactones (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHypervalent iodine oxidation of p-alkoxyphenols and related compounds: a general route to p-benzoquinone monoacetals and spiro lactonesYasumitsu Tamura, Takayuki Yakura, Junichi Haruta, and Yasuyuki KitaCite this: J. Org. Chem. 1987, 52, 17, 3927–3930Publication Date (Print):August 1, 1987Publication History Published online1 May 2002Published inissue 1 August 1987https://pubs.acs.org/doi/10.1021/jo00226a041https://doi.org/10.1021/jo00226a041research-articleACS PublicationsRequest reuse permissionsArticle Views3960Altmetric-Citations292LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
2‐Mercaptoethylamine, a competitive inhibitor of spermidine synthase in mammalian cells (1988)

Spermidine synthase from rat ventral prostate was inhibited by 2-mercaptoethylamine (MEA). Inhibition of spermidine synthase by MEA was competitive with respect to one of the substrates putrescine, but not competitive with respect to the other substrate decarboxylated S-adenosylmethionine. MEA markedly depressed spermidine and spermine contents in human erythroid leukemia K562 cells, suggesting that these changes resulted from the inhibitory effect of MEA on spermidine synthase in situ.
High‐resolution ultrasound in combat‐related peripheral nerve injuries (2016)

High resolution peripheral nerve US is a useful modality in assessment of combat-related PNI. Muscle Nerve, 2016 Muscle Nerve 54: 1139-1144, 2016.
The Atomos transactional programming language (2006)

Atomos is the first programming language with implicit transactions, strong atomicity, and a scalable multiprocessor implementation. Atomos is derived from Java, but replaces its synchronization and conditional waiting constructs with simpler transactional alternatives.The Atomos watch statement allows programmers to specify fine-grained watch sets used with the Atomos retry conditional waiting statement for efficient transactional conflict-driven wakeup even in transactional memory systems with a limited number of transactional contexts. Atomos supports open-nested transactions, which are necessary for building both scalable application programs and virtual machine implementations.The implementation of the Atomos scheduler demonstrates the use of open nesting within the virtual machine and introduces the concept of transactional memory violation handlers that allow programs to recover from data dependency violations without rolling back.Atomos programming examples are given to demonstrate the usefulness of transactional programming primitives. Atomos and Java are compared through the use of several benchmarks. The results demonstrate both the improvements in parallel programming ease and parallel program performance provided by Atomos.
Good breeding: Making sense of elite animal production in ancient greece (2011)

Consideration of social, environmental, and economic variables that helped to shape ancient Greek responses to animal management allows a way beyond the transhumance/agro-pastoralist debate. Each Greek community devised its own unique ways, methods, and goals for keeping animals in order to meet its unique social agenda. The differing social, environmental, and economic variables at Athens, Sparta, Thessaly, and Arcadia and central Greece resulted in differing responses to animal management.
Increasing Privacy in Mobile Communication Systems using Cryptographically Protected Objects (1997)

Confidential information contained in the transactional data created in mobile communication systems is not very well protected. We present an approach to protect entire objects against manipulation and disclosure, which allows to retain some control over information handed to a different entity or can be used to prevent reverse engineering of an object to obtain its original source. The approach is subsequently used in the context of mobile communication systems to protect the current location of a mobile user against unauthorized access.
Haemophilus influenzae Type b Immunization of Children With Sickle Cell Diseases (1988)

Haemophilus influenzae type B vaccine is recommended for children 1.5 to 6 years of age with sickle cell anemia, but the adequacy of their response is unknown. A total of 69 children with sickle cell syndromes, 1.5 to 5.6 years of age, were immunized with two vaccines alternatively, single blind. PRP vaccine was given to 36 children and a diphtheria toxoid conjugated vaccine, PRP-D, was given to 36. Coded pre- and postvaccine sera were tested by radioimmunoassay for anti-PRP antibody. The groups did not differ in age distribution or type of sickle hemoglobinopathy. Preexisting antibody levels were low in both vaccine groups; 65% were less than 0.15 microgram/mL. The vaccines were safe but associated with frequent minor reactions. PRP-D gave higher geometric mean titers and mean fold titer increase than PRP in all children (15.58 micrograms/mL [234-fold] v 2.63 micrograms/mL [29-fold]) and in the subgroups 1.5 to 2.5 years of age or with pretiter values less than 0.15 microgram/mL. Titers for 64% of children receiving PRP and 94% receiving PRP-D were greater than or equal to 1.0 microgram/mL. Thus, both vaccines were useful in this population, but PRP-D was more immunogenic. Duration of antibody levels postvaccination, booster responses, and PRP-D immunogenicity in younger children with sickle cell syndromes all require further study.
Abstract 4146: The expression of exosomal microRNA in serum of patients with esophageal squamous cell carcinoma (2012)

Abstract Background: Exosomes are 40 -100 nm membrane vesicles secreted by various cells such as T cells, platelets, and epithelial cells by exocytosis. Exosomes are found in blood, urine, amniotic fluid, and malignant ascites, and contain distinct subsets of microRNAs (miRs) depending upon the tumor from which they are secreted. Exosomes play a major role in cell-to-cell communication, targeting cells to transfer exosomal molecules including proteins, mRNAs, and microRNAs by an endocytosis-like pathway. Recent reports imply that miRNAs can be stably detected in circulating plasma and serum since miRNAs are packaged by exosomes to be protected from RNA degradation. We have previously reported that overexpression of miR-21 was observed in patients with esophageal squamous cell carcinoma. miR-26a is also known to be overexpressed in esophageal cancer. Objective: Aim of this study is to clarify the expression levels of miR-21 and miR-26a in exosomes from the serum of esophageal cancer patients. Patients and method: We extracted exosomes from serum of 20 esophageal cancer patients (ESCC group) and of 20 benign disease cases without inflammation (control group) by September, 2010 from October, 2009. We separated exosomes from serum, and then extracted total RNA including microRNA from exosome. Furthermore, using quantitative quantitative RT-PCR, we analyzed expression of miR-21, miR-26a where overexpression was confirmed in esophageal cancer in a past report. Results: The expression levels of miR-21 in exosomes were significantly higher in ESCC than those in control (P &amp;lt;0.001), while miR-26a expression levels in ESCC were tended to be higher than those in controls. Furthermore, we analyzed the supernatant which extracted exosomes from serum. There was almost no expression of both miRs in the supernatant after extraction of exosomes. When we compared exosomal and serum levels of miR-21, no correlation was observed between them. Conclusion: We have confirmed the elevated levels of exosomal miR-21 in the serum of patients with ESCC compared with the control. Although further analysis is needed to clarify the biological meaning of the elevated exosomal miR in the serum, the exosomal miR may become new biomarkers for ESCC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4146. doi:1538-7445.AM2012-4146
<title>Electrical alternative to pulsed lasers in vitreoretinal surgery</title> (1997)

Cavitation bubbles have been shown to be a driving force of tissue cutting during pulsed laser applications in vitreoretinal surgery. Such bubbles are generated by fast overheating of water due to laser radiation absorption in either water or in tissue or due to the dielectric breakdown in the focused laser beam. An alternative approach proposed in this paper is the generation of cavitation bubbles by the fast overheating of the liquid conductive medium by a short pulse of electric current. An electrical system based on a tapered microelectrode has been developed for generation of a high voltage sub-microsecond discharge in physiological medium. The dynamics of the associated cavitation bubbles was similar to that observed with ns-pulsed fiber-delivered lasers. A highly localized zone of power dissipation--about 20 micrometers in size--resulted in a low threshold energy of cavitation bubble generation--about 3 (mu) J--in comparison to the laser-based intraocular surgical systems. The minimal distance of safe applications of this device was measured in-vitro and in-vivo as a function of energy and was compared with the ArF excimer and IR laser-based systems. The proposed device can become a convenient and a cost- effective alternative to lasers in vitreoretinal microsurgery.
Blocking endogenous peroxidases: a cautionary note for immunohistochemistry (2007)

Dear Editor, In two recent JCMM papers dealing with the staining of various human tissue antigens, divergent approaches for blocking endogenous peroxidase activity were reported. As such, Gray et al.[1] inhibited this intrinsic enzyme with a 0.9% hydrogen peroxide (H2O2) solution whereas Ranieri et al.[2] performed the blockade with a 3% H2O2 solution. This arbitrariness has prompted our present letter. Immunohistochemistry (IHC) applied to formalin-fixed, paraffin-embedded tissue samples is governed by standard operating procedures like any other methodology in biomedicine. One important milestone in IHC standardization has been the revelation of endogenous biotin as a confounding factor along with measures to minimize its contribution to causing staining errors [3–5]. However, IHC pitfalls can also have other origins such as the insufficient quenching of endogenous peroxidases whenever using peroxidase-based detection methods. Despite the existence of expert manuals according to which these enzymes should be inhibited by applying a solution containing 3% H2O2[6] and studies abiding by this recommendation [2, 5, 7–9], some research groups still publish staining approaches in which blockade has erroneously been performed with less concentrated H2O2 solutions, e.g. by means of a 0.9%[1] or even 0.3%[10] solution. In this context, it was already shown that, for instance, when endogenous peroxidases were blocked by means of a 0.3% H2O2 solution a breast carcinoma was (falsely) positive for a particular protein, yet when blockade was performed by employing a 3% H2O2 solution, the same specimen stained negatively for that antigen [9]. It should be emphasized that all other conditions including primary antibody concentrations were identical in the two experimental arms at a given incubation temperature [9]. Therefore, the purpose of this note is to alert investigators to henceforth implement established techniques to avoid this mistake in order to prevent the emergence of staining artifacts associated with falsely positive IHC results and consequently augment the comparability of data generated in different laboratories on the same subject of interest. Given the increasing importance of proteomics and (intracellular) protein biomarkers for the diagnosis of human disease, appropriate countermeasures to avert this immunohistochemical pitfall should have particular relevance.
Vaginal Application of Testosterone: A Study on Pharmacokinetics and the Sexual Response in Healthy Volunteers (2006)

A single dose of vaginally applied testosterone propionate elevates serum levels of testosterone and free testosterone within 6 hours. Nevertheless, this acute rise in androgens has no effects on the female sexual response.
Gastric True Leiomyoma (2007)

In conclusion, gastric leiomyomas are mainly located in the cardia and usually appeared as homogenous low attenuated masses on computed tomography.
Polymerizable Complex Synthesis of Pure Sr2NbxTa2-xO7 Solid Solutions with High Photocatalytic Activities for Water Decomposition into H2 and O2 (2002)

Phase-pure solid solutions with the composition of Sr2NbxTa2-xO7 (SNT, x = 0−2) were prepared at 900 °C for 5 h by the Pechini-type polymerizable complex (PC) technique, based upon polymerization between citric acid and ethylene glycol. The two end compounds, Sr2Ta2O7 (x = 0) and Sr2Nb2O7 (x = 2), produced H2 and O2 in a stoichiometric ratio from pure water under UV light irradiation without a NiO cocatalyst. The photocatalytic activity of SNT for the water decomposition was greatly improved by loading NiO as a cocatalyst for a whole range of x. The photocatalytic activity was dramatically decreased approximately by 1 order of magnitude once Ta has been replaced by Nb, even when the amount of Nb was small. For all of the NiO-loaded SNT samples, water was stoichiometrically decomposed into H2 and O2. While samples prior to the complete crystallization showed very low activities despite their high surface area, the corresponding photocatalytic activities of well-crystallized samples depended primarily on their surface area. The low photocatalytic activities of such premature samples were interpreted as a consequence of the increased number of lattice defects acting as inactivation centers. The maximum photocatalytic activity was obtained for NiO (0.15 wt %)/Sr2Ta2O7 prepared by the PC method at 800 °C for 48 h; the photocatalyst having a specific surface area of 10.4 m2·g-1 produced H2 and O2 from pure water with specific rates of 3517 and 1733 μmol·h-1·g-1, respectively, 3.5 times larger than the best result for a sample prepared by the conventional solid-state reaction method.
Genotype-phenotype correlations of DHP receptor α1-subunit gene mutations causing hypokalemic periodic paralysis (1997)

Hypokalemic periodic paralysis (hypoKPP) is an autosomal dominant or sporadic disorder characterized by periodic, reversible attacks of muscle weakness. Mutations in the skeletal muscle dihydropyridine receptor alpha 1-subunit that functions as a calcium channel (CACNL1A3) cause hypoKPP. We studied a group of 45 hypoKPP probands and demonstrated mutations in 30 of them. When compared with patients in whom CACNL1A3 mutations were not identified, those with mutations had an earlier age of onset and more often had a family history of hypoKPP. To date, three mutations have been identified. The R1239G mutation has only been found in one family. Of the 30 probands with recognized mutations, R528H accounted for 43% and R1239H was seen in 53%. Age of onset and potassium levels during attacks were lower in patients with the R1239H mutation than those with R528H. Cardiac dysrhythmias co-segregated with hypoKPP in one small kindred with the R528H mutation. No mutations were identified in exons of the gene encoding the S4 segments of domains one and three or the cytoplasmic loop between domains two and three. In addition to the 45 hypoKPP probands, an additional 11 probands with clinical variants of hypoKPP (three thyrotoxic hypoKPP and eight Andersen syndrome patients) were examined for CACNL1A3 mutations and none were found.
Sugar substitutes: Health controversy over perceived benefits (2011)

Sugar is an inseparable part of the food we consume. But too much sugar is not ideal for our teeth and waistline. There have been some controversial suggestions that excessive sugar may play an important role in certain degenerative diseases. So artificial sweeteners or artificially sweetened products continue to attract consumers. A sugar substitute (artificial sweetener) is a food additive that duplicates the effect of sugar in taste, but usually has less food energy. Besides its benefits, animal studies have convincingly proven that artificial sweeteners cause weight gain, brain tumors, bladder cancer and many other health hazards. Some kind of health related side effects including carcinogenicity are also noted in humans. A large number of studies have been carried out on these substances with conclusions ranging from "safe under all conditions" to "unsafe at any dose". Scientists are divided in their views on the issue of artificial sweetener safety. In scientific as well as in lay publications, supporting studies are often widely referenced while the opposing results are de-emphasized or dismissed. So this review aims to explore the health controversy over perceived benefits of sugar substitutes.
Adaptation of an Asperity Ploughing Model to Measured Roll Topographies (2004)

A previously published asperity ploughing model has been adapted in order to approximate the measured as‐ground roll surface topography. The model is then integrated with classical cold rolling plastic deformation equations including coupling to the lubricant film evolution through the roll bite. The friction distribution through the roll bite is thus a function of the specific details of the roll surface topography as well as the process parameters. predictions of roll force, torque and forward slip as well as sliding distance and volume of metal swept out by the asperities are then made and compared to experimental measurements for an aluminum alloy rolled on a laboratory rolling mill.
Determinants of humoral and cellular immune responses to three doses of mRNA SARS-CoV-2 vaccines in older adults: a longitudinal cohort study (2023)

Norwegian Institute of Public Health, Norwegian Ministry of Health, Research Council of Norway, and Coalition for Epidemic Preparedness Innovations.
Keep it Unreal: Bridging the Realism Gap for 2.5D Recognition with Geometry Priors Only (2018)

With the increasing availability of large databases of 3D CAD models, methods for depth-based recognition of localized objects can be trained on an uncountable number of synthetically rendered images. However, discrepancies with the real data acquired from various depth sensors still noticeably impede progress. Previous works adopted unsupervised approaches to generate more realistic depth data, but they all require real scans for training, even if unlabeled. This still represents a strong requirement, especially when considering real-life/industrial settings where real training images are hard or impossible to acquire, but texture-less 3D models are available. We thus propose a novel approach leveraging only CAD models to bridge the realism gap. Purely trained on synthetic data, playing against an extensive augmentation pipeline in an unsupervised manner, our generative adversarial network learns to effectively segment depth images and recover the clean synthetic-looking depth information even from partial occlusions. As our solution is not only fully decoupled from the real domains but also from the task-specific analytics, the pre-processed scans can be handed to any kind and number of recognition methods also trained on synthetic data. Through various experiments, we demonstrate how this simplifies their training and consistently enhances their performance, with results on par with the same methods trained on real data, and better than usual approaches doing the reverse mapping.
ChemInform Abstract: ISOLATION OF UNSTABLE BIS(ETA(5)‐CYCLOPENTADIENYLCOBALT) TRICARBONYL FROM IRRADIATION OF ETA(5)‐CYCLOPENTADIENYLCOBALT DICARBONYL, THERMAL REACTIONS OF THIS BINUCLEAR COMPLEX LEADING TO STARTING MATERIAL AND TRINUCLEAR AND TETRANUCLEAR COBALT(I) COMPLEXES (1974)

Abstract Mittels NMR‐Technik wird die Bestrahlung von (I) in Deuteriobenzol, Cyclohexan oder Deuteriotoluol bei Ausschluß von Sauerstoff und Wasser untersucht.
Carbon Dioxide Capture Utilizing Solid Sorbents (2006)

The objective of this work is to develop regenerable sorbents that have high selectivity, efficient regenerability, and high adsorption capacity for CO2 over wide temperature ranges. These properties are critical for the success of the PSA/PSS and TSA/TSS processes.
[Utilization of the right to maternity leave and resumption of work after delivery. A longitudinal prospective study]. (1993)

A longitudinal interview study of 360 mothers was carried out to investigate: 1) utilization of maternity leave by the parents, 2) mothers' resumption of occupation after delivery and 3) duration of breast feeding seen in correlation with the mothers' resumption of work. 1) 95% of the families utilized the entire maternity leave. In 92% of the families, the mothers utilized all 24 weeks and, in 3% of the families, the fathers took part in the maternity leave. Only 46% of the fathers utilized the right to take leave in connection with delivery and 14% employed their holiday but were at home for a significantly shorter period. 2) Only one fourth of the mothers had resumed work 24 weeks after the delivery. 44% of the mothers prolonged the maternity leave with their holiday and 32% prolonged the maternity leave even longer. One year after delivery, significantly more mothers were housewives than previously. 3) A significantly positive correlation was found between the time for maternal return to work and the duration of breast feeding. We conclude that almost all of the families utilized the maternity leave and that prolongation of maternity leave (which is 24 weeks after delivery at present) might be necessary.