gebhart/patrepeval huggingface dataset:
Effects of Inlet Geometry on Hydraulic Performance of Box Culverts (2006)

Each year the South Dakota Department of Transportation (SD DOT) designs and builds many cast-in-place (CIP) and precast box culvert structures that allow drainage to pass under roadways. The CIP boxes typically have 30-degree flared wing walled and the precast have straight wing walls with 4-in bevel on the inside edges of the wing walls and top slab. Previous research, SD93-12, conducted on a limited number of single barrel box culverts, indicated that further research was necessary to determine the effects of multiple barrel structures, loss coefficients of unsubmerged outlets, and to determine the effect of 12-in corner fillets versus 6-in corner fillets. In order to optimize the design of both types of box culverts, it was also necessary to determine the effects of span-to-rise ratio, skewed end condition, and optimum edge condition on typical box culvert installations"--Technical report documentation page.\n
Immunotherapy Affects the Seasonal Increase in Specific IgE and Interleukin‐4 in Serum of Patients with Seasonal Allergic Rhinitis (1997)

This study was designed to determine seasonal changes in cytokines, soluble CD23 and specific IgE in the serum of patients with seasonal allergic rhinitis, and the effect of immunotherapy on these seasonal changes. Fifty-four patients with seasonal allergic rhinitis caused by Japanese ceder pollens were divided into a medication group and an immunotherapy group. The patients of the medication group were treated with non-sedating antihistamines alone during the pollen season. The patients of the immunotherapy group had been treated for variable periods (mean, 5.0 +/- 3.2 years) with immunotherapy using japanese cedar pollen antigens. Serum samples were collected before and during the pollen season from each patient, to determine specific IgE, interleukin-4 (IL-4), interferon-gamma (IFN-gamma) and soluble CD23 levels in serum. A significant increase in specific IgE and IL-4 and a significant decrease in IFN-gamma were observed during the pollen season in the medication group. In contrast, in the immunotherapy group, none of specific IgE, IL-4 and IFN-gamma was significantly changed following natural exposure to pollens. However, these effects were not significant in patients undergoing immunotherapy for 3 or fewer years. Seasonal rates of increase in specific IgE and IL-4 differed significantly between good responders and poor responders to immunotherapy, but seasonal rates of decrease in IFN-gamma did not. A seasonal rate of increase in soluble CD23 was significantly correlated with a seasonal rate of increase in specific IgE, in both the medication and the immunotherapy groups. The seasonal rate of increase in soluble CD23 was significantly smaller in the good responders than in the poor responders to immunotherapy. In conclusion, pollen immunotherapy reduces the seasonal increase in specific IgE, IL-4 and soluble CD23 in serum, and in addition switches the seasonal preferential activation of Th-2 cells to reciprocal activation of Th-1 cells with treatment over several years. It is likely that the mechanisms responsible for the clinically beneficial effects of immunotherapy principally involve the modulation of Th-2 rather than Th-1 cytokines.
Aerothermodynamic heating environment and thermal protection materials comparison for manned Mars-earth return vehicles (1991)

The aerothermodynamic environment during the earth return portion of a specific manned Mars mission is studied. Particular attention is given to the earlier smaller crew return capsule and its thermal protection system requirements. Data are presented on the stagnation region of a generic Mars return capsule. Insulation material thicknesses required to maintain allowable structural temperatures throughout a prolonged heat soak period are estimated.
Dural afferents express acid-sensing ion channels: A role for decreased meningeal pH in migraine headache (2010)

Migraine headache is one of the most common neurological disorders. The pathological conditions that directly initiate afferent pain signaling are poorly understood. In trigeminal neurons retrogradely labeled from the cranial meninges, we have recorded pH-evoked currents using whole-cell patch-clamp electrophysiology. Approximately 80% of dural-afferent neurons responded to a pH 6.0 application with a rapidly activating and rapidly desensitizing ASIC-like current that often exceeded 20nA in amplitude. Inward currents were observed in response to a wide range of pH values and 30% of the neurons exhibited inward currents at pH 7.1. These currents led to action potentials in 53%, 30% and 7% of the dural afferents at pH 6.8, 6.9 and 7.0, respectively. Small decreases in extracellular pH were also able to generate sustained window currents and sustained membrane depolarizations. Amiloride, a non-specific blocker of ASIC channels, inhibited the peak currents evoked upon application of decreased pH while no inhibition was observed upon application of TRPV1 antagonists. The desensitization time constant of pH 6.0-evoked currents in the majority of dural afferents was less than 500ms which is consistent with that reported for ASIC3 homomeric or heteromeric channels. Finally, application of pH 5.0 synthetic-interstitial fluid to the dura produced significant decreases in facial and hind-paw withdrawal threshold, an effect blocked by amiloride but not TRPV1 antagonists, suggesting that ASIC activation produces migraine-related behavior in vivo. These data provide a cellular mechanism by which decreased pH in the meninges following ischemic or inflammatory events directly excites afferent pain-sensing neurons potentially contributing to migraine headache.
1,2,3‐Triazole: Multifunktionswerkzeuge für die Peptidchemie (2013)

Abstract 1,2,3‐Triazole sind nichtnatürliche Bausteine mit bioisosteren Eigenschaften. Sie dienen in der Peptidchemie als effektive Kopplungsschnittstellen für Biomoleküle, um multifunktionale Strukturen aufzubauen.
Glycosylation of Recombinant Antigenic Proteins from Mycobacterium tuberculosis: In Silico Prediction of Protein Epitopes and Ex Vivo Biological Evaluation of New Semi-Synthetic Glycoconjugates (2017)

Tuberculosis is still one of the most deadly infectious diseases worldwide, and the use of conjugated antigens, obtained by combining antigenic oligosaccharides, such as the lipoarabinomannane (LAM), with antigenic proteins from <i>Mycobacterium tuberculosis</i> (MTB), has been proposed as a new strategy for developing efficient vaccines. In this work, we investigated the effect of the chemical glycosylation on two recombinant MTB proteins produced in <i>E. coli</i> with an additional seven-amino acid tag (recombinant Ag85B and TB10.4). Different semi-synthetic glycoconjugated derivatives were prepared, starting from mannose and two disaccharide analogs. The glycans were activated at the anomeric position with a thiocyanomethyl group, as required for protein glycosylation by selective reaction with lysines. The glycosylation sites and the ex vivo evaluation of the immunogenic activity of the different <i>neo-</i>glycoproteins were investigated. Glycosylation does not modify the immunological activity of the TB10.4 protein. Similarly, Ag85B maintains its B-cell activity after glycosylation while showing a significant reduction in the T-cell response. The results were correlated with the putative B- and T-cell epitopes, predicted using a combination of in silico systems. In the recombinant TB10.4, the unique lysine is not included in any T-cell epitope. Lys30 of Ag85B, identified as the main glycosylation site, proved to be the most important site involved in the formation of T-cell epitopes, reasonably explaining why its glycosylation strongly influenced the T-cell activity. Furthermore, additional lysines included in different epitopes (Lys103, -123 and -282) are also glycosylated. In contrast, B-cell epitopic lysines of Ag85B were found to be poorly glycosylated and, thus, the antibody interaction of Ag85B was only marginally affected after coupling with mono- or disaccharides.
Efficient Event-based Intrusion Monitoring using Probabilistic Distributions (2022)

Autonomous intrusion monitoring in unstructured complex scenarios using aerial robots requires perception systems capable to deal with problems such as motion blur or changing lighting conditions, among others. Event cameras are neuromorphic sensors that capture per-pixel illumination changes, providing low latency and high dynamic range. This paper presents an efficient event-based processing scheme for intrusion detection and tracking onboard strict resource-constrained robots. The method tracks moving objects using a probabilistic distribution that is updated event by event, but the processing of each event involves few low-cost operations, enabling online execution on resource-constrained onboard computers. The method has been experimentally validated in several real scenarios under different lighting conditions, evidencing its accurate performance.
The Effect of Neuromuscular Blockade on Pedicle Screw Stimulation Thresholds (2000)

Neuromuscular blockade should be less than 80% when using pedicle screw electrical stimulation testing.
Midcourse correction to a clinical trial when the event rate is underestimated: the Look AHEAD (Action for Health in Diabetes) Study (2012)

The Look AHEAD (Action for Health in Diabetes) Study is a long-term clinical trial that aims to determine the cardiovascular disease (CVD) benefits of an intensive lifestyle intervention (ILI) in obese adults with type 2 diabetes. The study was designed to have 90% statistical power to detect an 18% reduction in the CVD event rate in the ILI Group compared to the Diabetes Support and Education (DSE) Group over 10.5 years of follow-up. The original power calculations were based on an expected CVD rate of 3.125% per year in the DSE group; however, a much lower-than-expected rate in the first 2 years of follow-up prompted the Data and Safety Monitoring Board (DSMB) to recommend that the Steering Committee undertake a formal blinded evaluation of these design considerations. The Steering Committee created an Endpoint Working Group (EPWG) that consisted of individuals masked to study data to examine relevant issues. The EPWG considered two primary options: (1) expanding the definition of the primary endpoint and (2) extending follow-up of participants. Ultimately, the EPWG recommended that the Look AHEAD Steering Committee approve both strategies. The DSMB accepted these modifications, rather than recommending that the trial continue with inadequate statistical power. Trialists sometimes need to modify endpoints after launch. This decision should be well justified and should be made by individuals who are fully masked to interim results that could introduce bias. This article describes this process in the Look AHEAD study and places it in the context of recent articles on endpoint modification and recent trials that reported endpoint modification.
Electronic Properties of 1,5-Diaminonaphthalene:Tetrahalo-1,4-benzoquinone Donor–Acceptor Cocrystals (2017)

We have investigated the electronic properties of four charge-transfer cocrystals involving 1,5-diaminonaphthalene (DAN) as donor and fluoranil (FA), chloranil (CA), bromanil (BA), and iodanil (IA) as acceptors. While DAN-FA, DAN-CA, and DAN-BA crystallized in a mixed-stack fashion, DAN-IA crystallized with segregated stacks. For the mixed-stack cocrystals, electronic-structure calculations using density functional theory predict large electron–hole couplings with small effective masses, which strongly suggests that these DAN-XA cocrystals are suitable for charge-transport applications. Among the four cocrystals, DAN-CA crystallized in a noncentrosymmetric space group; according to our computational analysis, it is predicted to be weakly ferroelectric with a second-order electrical susceptibility (χ(2)) similar to that of urea. The ionicities (ρ) of the cocrystals calculated using Mulliken population compare well with the experimental results. The couplings between donor and acceptor molecules in DAN-IA are very small, leading to a very small ρ. This is not typical for a system with a segregated-stack packing motif, indicating that hydrogen and halogen bondings can have a strong impact on the structure–property relations in cocrystals.
Acoustic Parameters Related to Behavioral Discrimination of Emotional Vocalizations in Java Sparrows (2022)

Animals emit vocalizations related to internal or external states, such as hormone levels or predation risks. The Java Sparrow Lonchura oryzivora, a songbird, produces similar trill-structured calls in both aggressive and affiliative situations. A previous study found that trills produced in aggressive situations (AG trills) are faster, louder, and have a wider range of frequencies than trills produced in affiliative situations (AF trills). To assess whether Java Sparrows perceive these trills as different calls, we conducted a playback experiment using a habituation-dishabituation paradigm. In this paradigm, we first played a stimulus set for ten minutes (habituation stimulus), and after that we played either a test stimulus set or a control stimulus set. We analyzed behavioral changes in the study bird that took place between the last minute of the habituation stimulus and the next stimulus set (test or control). As trill stimuli, we used natural AG and AF trills (Experiment 1) and trills in which the trill rates and syllables types were modified (Experiment 2). The results showed that Java Sparrows distinguish between AG and AF trills (Experiment 1). However, when the trill acoustic structure was modified, they distinguished between the different syllable types, but not between different trill rates. As we used a natural behavior as an index, we could not measure the perceptual limit of trill discrimination in these birds. Instead, here, we asked whether the difference between AG and AF trills is meaningful or not, and which acoustic features were important for discrimination. To fully understand how birds perceive vocalizations in the context of communication, more experiments are required, both controlled experiments utilizing operant conditioning and electrophysiology, and multimodal experiments that reflect natural social relationships.
An Innovated DVD Multi-Angle Content And A Desired DVD Player (2006)

Although DVD specification introduced multi-angle video contents, until today, the multi-angle feature is not used much yet. This paper depicts an innovation of true user-interactive DVD multi-angle playback technology, and discusses the DVD player design to optimize the playback technology.
Path replay backpropagation (2021)

Differentiable physically-based rendering has become an indispensable tool for solving inverse problems involving light. Most applications in this area jointly optimize a large set of scene parameters to minimize an objective function, in which case reverse-mode differentiation is the method of choice for obtaining parameter gradients. However, existing techniques that perform the necessary differentiation step suffer from either statistical bias or a prohibitive cost in terms of memory and computation time. For example, standard techniques for automatic differentiation based on program transformation or Wengert tapes lead to impracticably large memory usage when applied to physically-based rendering algorithms. A recently proposed adjoint method by Nimier-David et al. [2020] reduces this to a constant memory footprint, but the computation time for unbiased gradient estimates then becomes quadratic in the number of scattering events along a light path. This is problematic when the scene contains highly scattering materials like participating media. In this paper, we propose a new unbiased backpropagation algorithm for rendering that only requires constant memory, and whose computation time is linear in the number of scattering events (i.e., just like path tracing). Our approach builds on the invertibility of the local Jacobian at scattering interactions to recover the various quantities needed for reverse-mode differentiation. Our method also extends to specular materials such as smooth dielectrics and conductors that cannot be handled by prior work.
Laser-plasma interaction experiments and diagnostics at NRL (Naval Research Laboratory). Memorandum report (1983)

Laser plasma interaction experiments have now advanced to the point where very quantitative measurements are required to elucidate the physic issues important for laser fusion and other applications. Detailed time-resolved knowledge of the plasma density, temperature, velocity gradients, spatial structure, heat flow characteristics, radiation emission, etc, are needed over tremendou ranges of plasma density and temperature. Moreover, the time scales are very short, aggrevating the difficulty of the measurements further. Nonetheless, such substantial progress has been made in diagnostic development during the past few years that we are now able to do well diagnosed experiments. In this paper the authors review recent diagnostic developments for laser-plasma interactions, outline their regimes of applicability, and show examples of their utility. In addition to diagnostics for the high densities and temperature characteristic of laser fusion physics studies, diagnostics designed to study the two-stream interactions of laser created plasma flowing through an ambient low density plasma will be described.
Revealing the Charge‐Transfer Interactions in Self‐Assembled Organic Cocrystals: Two‐Dimensional Photonic Applications (2015)

A new crystal of a charge-transfer (CT) complex was prepared through supramolecular assembly and it has unique two-dimensional (2D) morphology. The CT nature of the ground and excited states of this new Bpe-TCNB cocrystal (BTC) were confirmed by electron spin resonance measurements, spectroscopic studies, and theoretical calculations, thus providing a comprehensive understanding of the CT interactions in organic donor-acceptor systems. And the lowest CT1 excitons are responsible for the efficient photoluminescence (Φ(PL)=19%), which can actively propagate in individual 2D BTCs without anisotropy, thus implying that the optical waveguide property of the crystal is not related to the molecular stacking structure. This unique 2D CT cocrystal exhibits potential for use in functional photonic devices in the next-generation optoelectronic communications.
Time-resolved photon counting for multiplexed DNA electrophoreses separations (2001)

Monte Carlo simulations are used to evaluate time resolved photon counting as a means for identifying and quantifying overlapping electropherogram bands, which have been labeled by dyes with disparate fluorescence lifetimes.
A Foldable Antagonistic Actuator (2014)

We report on an actuator based on dielectric elastomers that is capable of antagonistic actuation and passive folding. This actuator enables foldability in robots with simple structures. Unlike other antagonistic dielectric elastomer devices, our concept uses elastic hinges to allow the folding of the structure, which also provides an additional design parameter. To validate the actuator concept through a specific application test, a foldable elevon actuator with outline size of 70 mm × 130 mm is developed with angular displacement range and torque specifications matched to a 400-mm wingspan micro-air vehicle (MAV) of mass 130 g. A closed-form analytical model of the actuator is constructed, which was used to guide the actuator design. The actuator consists of 125-μm-thick silicone membranes as the dielectric elastomers, 0.2mm-thick fiberglass plate as the frame structure, and 50-μm-thick polyimide as the elastic hinge. We measured voltage-controllable angular displacement up to ±26° and torque of 2720 mN · mm at 5 kV, with good agreement between the model and the measured data. Two elevon actuators are integrated into the MAV, which was successfully flown, with the foldable actuators providing stable and well-controlled flight. The controllability was quantitatively evaluated by calculating the correlation between the control signal and the MAV motion, with a correlation in roll axis of over 0.7 measured during the flights, illustrating the high performance of this foldable actuator.
Sur le dosage uranométrique de l'anion fluorure (1937)

Abstract 1. Les fluorures alcalins donnent avec les sels uraneux des fluorures doubles du type M I UF 5 , sels très peu solubles dans l'eau.
ChemInform Abstract: REDUCTION OF 1,3‐DIIMINES. A NEW AND GENERAL METHOD OF SYNTHESIS OF Γ‐DIAMINES, β‐AMINO KETONES, AND DERIVATIVES WITH TWO AND THREE CHIRAL CENTERS (1983)

Abstract Aus den Diiminen (I) bzw. Isomeren davon, deren tautomere Formen diskutiert werden, erhält man bei der Reduktion mit Lithiumalanat nach Hydrolyse die Amino‐ketone (II), die in Hydrochloride (III) bzw. Acyl‐Verbindungen (V) übergeführt werden.
A multi-link system control strategy based on biological reaching movement (2006)

Abstract In the multi-link arm control process, the problems of trajectory planning and trajectory realization have been recognized as being of key importance. We developed a technique by which to realize a reaching movement control of the multi-link arm system, which was inspired by experimental results for reaching movements of macaques or human beings. The proposed method can treat the effect of the dynamics of the multi-link system and the trajectory planning of the end-effector, which has a bell-shaped speed profile, as well as the difficulties of redundancies of multi-link systems. Two-link arm reaching movement experiments revealed the same features, as demonstrated by the results of biological experiments on humans and macaques. In addition, the results obtained using a two-dimensional four-link model in a standing-up movement control experiment agreed well with 'standing-up from a chair' movement of human beings. Since the proposed method has a simple structure and its implementation process is simple, the proposed method will be effective for use in a multi-link system control strategy. Keywords: MULTI-LINK CONTROLBIOLOGICALLY INSPIRED CONTROLBELL-SHAPED SPEED PROFILE
Test for detection and location of intermittent faults in combinational circuits (1997)

Faults in combinational circuits are either permanent or intermittent. Intermittent faults tend to be environment-dependent; hence altering the environment might rectify these faults. These faults can be detected by applying random input-vectors (IV). The existence of random intermittent faults might require applying more random IV before detection. The detection of permanent faults requires fewer random IV but correction demands location and replacement of the faulty device, if repair is not feasible. Thus correction of a permanent fault costs more than that of an intermittent fault. The correction cost can be reduced by detecting the type of fault. Since most operational failures in a circuit are due to intermittent faults, it is very important to detect the type of fault in order to find a cheaper solution. This paper discusses the behavior of permanent and intermittent faults in combinational circuits, and introduces a test-detection model (TDM) for these faults. The error latency for an intermittent fault is derived. Two test-strategies are intermixed in the model: random testing for fault-detection, and deterministic testing for deciding on the type of fault. The activity of intermittent faults that requires the minimum number of IV for detection is emphasized. Simulation is used to demonstrate the validity of TDM. Although the variables required in TDM can be difficult to evaluate, estimation of their values is not impossible. A worst-case analysis can always be adopted, where variables are easily evaluated, to find an upper bound on the error latency; thus detection of an intermittent fault is assured with a very high probability. The cost-saving offered by intermittent-fault corrections shows the practical aspect of TDM.