gebhart/patrepeval huggingface dataset:
Morphological and Histochemical Characteristics of Pigments in Aging F344 Rats (1980)

Pigments found in spleen, lymph nodes, kidney, thyroid, adrenal, liver, ovary, central nervous system, heart and connective tissues of aging F344 rats were studied morphologically and histochemically. The morphology of the pigment accumulations depended on the tissue affected. Pigments resembling lipofuscin were found in most of these tissues. The ultrastructural appearance of siderosomes in splenic macrophages suggested that erythrocyte degradation was responsible for pigment production. Adrenal ultrastructure showed that lipofuscin-like material may have originated from degradation of lipid droplets of epithelial cells.
A model to predict the ultrasonic field radiated by magnetostrictive effects induced by EMAT in ferromagnetic parts (2017)

Conference of 15th Anglo-French Physical Acoustics Conference, AFPAC 2016 ; Conference Date: 13 January 2016 Through 15 January 2016; Conference Code:126251
Ion Mobility Analysis of Lipoprotein Subfractions Identifies Three Independent Axes of Cardiovascular Risk (2009)

PCA on lipoprotein subfractions yielded three independent components of CVD risk. Genetic analyses suggest these components represent independent mechanistic pathways for development of CVD.
Towards classification of experimental Laguerre–Gaussian modes using convolutional neural networks (2020)

Automated detection of orbital angular momentum (OAM) can tremendously contribute to quantum optical experiments. We develop convolutional neural networks to identify and classify noisy images of Laguerre–Gaussian (LG) modes collected from two different experimental set ups. We investigate the classification performance measures of the predictive classification models for experimental conditions. The results demonstrate accuracy and specificity above 90% in classifying 16 LG modes for both experimental set ups. However, the F-score, sensitivity, and precision of the classification range from 57% to 92%, depending on the number of imperfections in the images obtained from the experiments. This research could enhance the application of OAM light in telecommunications, sensing, and high-resolution imaging systems.
Gestión estratégica de la tecnología (1999)

En las ultimas decadas ha habido un creciente interes teorico y practico por integrar la tecnologia al proceso de planeacion de los negocios. Esto quiza no sorprenda ante la acelerada produccion de conocimientos tecnologicos para las actividades comerciales e industriales y las funciones internas de las organizaciones. Desde principios de la decada de los setenta, diversos estudiosos de la planeacion (Alien, 1977; Coates, 1971, 1976, Fisher y Pry, 1971) comenzaron a referirse a la necesidad de incorporar la tecnologia a dicho proceso, pero mas desde la perspectiva macro de la investigacion y el desarrollo o de la necesidad de incorporar el pronostico tecnologico. No es hasta finales de esa decada (Fusfeld, 1978), principios de la siguiente (Harris, 1981; Bitondo, 1981) y en la segunda mitad de los ochenta que surgen la mayoria de las contribuciones con base en el concepto de gerencia estrategica dela tecnologiacomo nuevo paradigma que pretende apoyar en la resolucion de las cuestiones mencionadas.
<title>Early diagnosis of cancers using fluorescence imaging of tissues</title> (1996)

The imaging system we have developed for early cancers detection, acquires and displays in real time, two different spectral images representing the same site excited alternately with an Argon laser and a Xenon lamp. A step by step engine and an optical system are used to alternate and focalize the two excitation lights through the endoscope optical canal. Image acquisition proceeded via a high pass filtered camera, is synchronized with excitation lights thanks to signals exchange between four electronic boards. Inter-image processing is performed to eliminate undesirable information. In-vivo fluorescence images showing bladder's lesions more contrasted than white lighted ones, have been obtained with a previous version of this system. The first results of the final system were achieved on phantoms simulating healthy and cancerous tissues.
Studies on water-soluble taxol derivatives (1991)

The importance of taxol as an anticancer drug lies not only in its activity in antitumor assays but also in its unique mechanism of action. Unfortunately, taxol is not water-soluble and therefore must be given in conjunction with emulsifying agents. Modifications of taxol were carried out in order to prepare water-soluble taxol derivatives. The C-2’ hydroxyl group of taxol was substituted with various groups to increase water solubility. The synthesized taxol derivatives, 2’-((3-sulfo-1-oxopropyl)oxy)taxol sodium salt, 2’-((4-((2-sulfoethyl)amino)-1,4-dioxobutyl)oxy)taxol sodium salt, and 2’-((4-((3-sulfopropyl)amino)-1,4-dioxobutyl)oxy)taxol sodium salt were more water-soluble than taxol. The synthetic pathways to these compounds are compared and discussed.
ATM, a DNA damage-inducible kinase, contributes to activation by high NaCl of the transcription factor TonEBP/OREBP (2004)

High NaCl activates the transcription factor tonicity-responsive enhancer/osmotic response element-binding protein (TonEBP/OREBP), resulting in increased transcription of several protective genes, including the glycine betaine/gamma-aminobutyric acid transporter (BGT1). High NaCl damages DNA, and DNA damage activates ataxia telangiectasia mutated (ATM) kinase through autophosphorylation on Ser-1981. TonEBP/OREBP contains ATM consensus phosphorylation sites at Ser-1197, Ser-1247, and Ser-1367. The present studies test whether ATM is involved in activation of TonEBP/OREBP by high NaCl. We find that raising osmolality from 300 to 500 mosmol/kg by adding NaCl activates ATM, as indicated by phosphorylation at Ser-1981. High urea and radiation also activate ATM, but they do not increase TonEBP/OREBP transcriptional activity like high NaCl does. Wortmannin, which inhibits ATM, reduces NaCl-induced TonEBP/OREBP transcriptional activation and BGT1 mRNA increase. Overexpression of wild-type TonEBP/OREBP increases ORE/TonE reporter activity much more than does overexpression of TonEBP/OREBP S1197A, S1247A, or S1367A. In AT cells (which express nonfunctional ATM), TonEBP/OREBP transcriptional and transactivating activity are further increased by expression of wild-type ATM but not of S1981A ATM. TonEBP/OREBP reciprocally coimmunoprecipitates with ATM kinase, demonstrating physical association. Additionally, antibody to ATM kinase supershifts TonEBP/OREBP bound to its cognate ORE/TonE DNA element. In AT cells, wortmannin further decreases high NaCl-induced increase in transcriptional activity, consistent with participation of signaling kinase(s) in addition to ATM. In conclusion, signaling via ATM is necessary for full activation of TonEBP/OREBP by high NaCl, but it is not sufficient.
Translocating captive female white-tailed deer (2022)

Context Thousands of captive white-tailed deer (Odocoileus virginianus) breeding facilities exist across North America for the purpose of producing trophy-class deer (i.e. exceptionally large-antlered). Many of these deer get marketed to private landowners, with the expectation that introduced deer will enhance genetics in the population, resulting in larger-antlered male deer. Previous research suggests that survival and reproductive success of translocated wild white-tailed deer are highly variable; however, little is known about the fate of white-tailed deer translocated from captive-breeding operations. Aims To assess the efficacy of translocating captive female white-tailed deer for the purpose of increasing average antler size within a high-fence property. Methods We translocated 24 adult female deer into a private, 300-ha high-fence shooting preserve in east-central Alabama over a 3-year period. We monitored survival, reproductive success, and fawn recruitment for the translocated deer by using VHF radio collars and vaginal-implant transmitters (VITs). Key results We found a 12-month survival rate of 0.54 for translocated deer. We captured nine fawns throughout our study, leading to a rate of 0.9 fawns per VIT, after accounting for doe mortality and premature VIT expulsion. We found 60-day and 6-month fawn survival rates of 0.33 and 0.22 respectively. Conclusions Survival of translocated captive deer was comparable to rates reported in previous studies that translocated wild deer, although lower than what is found in wild populations that undergo no translocation. Translocated does produced a low number of fawns relative to the national average, although fawn recruitment was within the range of survival rates reported in studies of wild deer. Implications We believe our findings provide a baseline of expectations for captive-deer translocations. Given our results, we believe it is infeasible to expect increased average antler size within this study site by translocating adult female white-tailed deer.
Phospholipids in clinical applications. (1991)

Phospholipids are noticed not only as components of biomembranes, but also as materials for clinical applications. Liposomes have been used as carrier vehicles of drugs, such as antifungal and anticancer drugs, and are expected for a new drug delivery system. Many clinical trials of these drugs encapsulated in liposomes have been progressed in the world wide area. Liposomes encapsulating hemoglobin have been investigated as an artificial blood. Specific drugs for infant respiratory distress syndrome using dipalmitoylphosphatidylcholine (DPPC), which is known as a main component of lung surfactant, have been developed, and some of these drugs have already come on market. Alkyl lysophosphatidylcholine derivatives have an unique antineoplastic function. In this review, we described recent progress and a prospect for the medical applications using phospholipids.
Flexible helical yarn swimmers (2016)

We investigate the motion of a flexible Stokesean flagellar swimmer realised as a yarn made of two intertwined elastomer fibres, one active, that can reversibly change its length in response to a local excitation causing transition to the nematic state or swelling, and the other one, a passive isotropic elastomer with identical mechanical properties. A propagating chemical wave may provide an excitation mechanism ensuring a constant length of the excited region. Generally, the swimmer moves along a helical trajectory, and the propagation and rotation velocity are very sensitive to the ratio of the excited region to the pitch of the yarn, as well as to the size of a carried load. External excitation by a moving beam is less effective, unless the direction of the beam is adjusted to rotation of the swimmer.
Binaural beamforming with spatial cues preservation for hearing aids in real-life complex acoustic environments (2017)

This work is introducing novel binaural beamforming algorithms for hearing aids, with a good trade-off between noise reduction and the preservation of the binaural cues for different types of sources (directional interfering talker sources, diffuse-like background noise). In the proposed methods, no knowledge of the interfering talkers' direction or the second order statistics of the noise-only components is required. Different classification decisions are considered in the time- frequency domain based on the power, the power difference, and the complex coherence of different available signals. Simulations are performed using signals recorded from multichannel binaural hearing aids, to validate the performance of the proposed algorithms under different acoustic scenarios and using different microphone configurations. For the simulations performed in this paper, a good knowledge of the target direction and propagation model is assumed. For hearing aids, this assumption is typically more realistic than the assumption of knowing the direction and propagation model of the interferer talkers. The comparison of the performance results is done with other algorithms that don't require information on the directions or statistics of the interfering talker sources and the background noise. The results indicate that the proposed algorithms can either provide nearly the same noise reduction as classical beamformers but with improved noise binaural cues preservation, or they can produce a good trade-off between noise reduction and noise binaural cues preservation.
Identification of Phosphates and Aluminate Nanotubes in a Vehicle-Aged Three-Way Automotive Catalyst (2004)

Extended abstract of a paper presented at Microscopy and Microanalysis 2004 in Savannah, Georgia, USA, August 1–5, 2004.
Author response: Single-color, ratiometric biosensors for detecting signaling activities in live cells (2018)

A novel panel of homoFRET biosensors that detect kinase and second messenger activity, called FLAREs, enables multiparameter imaging of signaling activities within a single live cell with a quantitative and ratiometric readout.
Neural network architecture for crossbar switch control (1991)

A Hopfield neural network architecture for the real-time control of a crossbar switch for switching pockets at maximum throughput is proposed. The network performance and processing time are derived from a numerical simulation of the transitions of the neural network. A method is proposed to optimize electronic component parameters and synaptic connections, and it is fully illustrated by the computer simulation of a VLSI implementation of 4*4 neural net controller. The extension to larger size crossbars is demonstrated through the simulation of an 8*8 crossbar switch controller, where the performance of the neural computation is discussed in relation to electronic noise and inhomogeneities of network components.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Laboratory Measurement of Microproppant Placement Quality using Split Core Plug Permeability under Stress (2018)

Abstract This paper describes the stress-dependent permeability of split shale core plugs from Eagle Ford, Bakken, and Barnett formation samples studied in presence of microproppants in microcracks. An analytical permeability model is developed, including the interaction between the fracture walls and monolayer microproppants under stress. The model is then used to analyze a series of pressure pulse decay measurements of the propped shale samples in the laboratory. The analysis provides the propped fracture permeability of the samples and predicts a parameter related to the quality of the proppant areal distribution in the fracture. The proppant placement quality can be used as a measure of success of the delivery of proppants into the fractures and to design stimulation in the laboratory.
Hilbert Space Embeddings of Hidden Markov Models (2018)

Hidden Markov Models (HMMs) are important tools for modeling sequence data. However, they are restricted to discrete latent states, and are largely restricted to Gaussian and discrete observations. And, learning algorithms for HMMs have predominantly relied on local search heuristics, with the exception of spectral methods such as those described below. We propose a nonparametric HMM that extends traditional HMMs to structured and non-Gaussian continuous distributions. Furthermore, we derive a localminimum-free kernel spectral algorithm for learning these HMMs. We apply our method to robot vision data, slot car inertial sensor data and audio event classification data, and show that in these applications, embedded HMMs exceed the previous state-of-the-art performance.
A New Look at the Traffic Management Problem and Where to Start (2011)

Traffic management is a major concern for cities around the world. The conventional traffic problem has been cast as a mismatch situation between supply and demand. This paper argues that this formulation is incomplete in that it admits solutions that ignore the impact on citizens all together, and hence unsustainable in the long run. In response, the authors propose a new formulation of the traffic management problem and outline focus areas while solving them for cities in developed and emerging/ developing geographies.
Susceptibility of inbred lines of oilseed rape, Brassica napus, to feeding damage by the crucifer flea beetle, Phyllotreta cruciferae (Goeze) [Coleoptera: Chrysomelidae], and its inheritance (1993)

Seventy-seven inbred lines of Brassica napus L. were assessed for antixenosis to damage by die crucifer flea beetle, Phyllotreta cruciferae (Goeze). The resistance was quantified by measuring the level of damage inflicted on seedlings of each line in laboratory tests. One of these lines, M12, was more susceptible than another line, L19, in a series of replicated tests, but individual seedlings could not be identified as resistant or susceptible because inter-seedling variation in the damage level was high. The F3 families from reciprocal crosses between L19 and M12 showed segregation for the resistance, demonstrating that the antixenosis has a genetic basis. Two or more genes probably control the expression of the resistance, but the number could not be estimated. Electrophoresis of seed endosperm proteins revealed a band, P-74, that occurred in M12 and eight cultivars of B. napus, but not in L19. This banding pattern was inherited as a simple recessive allele, but it proved not to be linked with the resistance in the F3 families. Further screening of B. napus for highly resistant genotypes and identification of linked genetic markers are needed to establish agronomically useful levels of flea beetle resistance in this crop. Key words: Insecta, resistance, canola, electrophoresis, endosperm proteins
Role of the C terminus of the α1C(CaV1.2) Subunit in Membrane Targeting of Cardiac L-type Calcium Channels (2000)

We have previously demonstrated that formation of a complex between L-type calcium (Ca(2+)) channel alpha(1C) (Ca(V)1.2) and beta subunits was necessary to target the channels to the plasma membrane when expressed in tsA201 cells. In the present study, we identified a region in the C terminus of the alpha(1C) subunit that was required for membrane targeting. Using a series of C-terminal deletion mutants of the alpha(1C) subunit, a domain consisting of amino acid residues 1623-1666 ("targeting domain") in the C terminus of the alpha(1C) subunit has been identified to be important for correct targeting of L-type Ca(2+) channel complexes to the plasma membrane. Although cells expressing the wild-type alpha(1C) and beta(2a) subunits exhibited punctate clusters of channel complexes along the plasma membrane with little intracellular staining, co-expression of deletion mutants of the alpha(1C) subunit that lack the targeting domain with the beta(2a) subunit resulted in an intracellular localization of the channels. In addition, three other regions in the C terminus of the alpha(1C) subunit that were downstream of residues 1623-1666 were found to contribute to membrane targeting of the L-type channels. Deletion of these domains in the alpha(1C) subunit resulted in a reduction of plasma membrane-localized channels, and a concomitant increase in channels localized intracellularly. Taken together, these results have demonstrated that a targeting domain in the C terminus of the alpha(1C) subunit was required for proper plasma membrane localization of the L-type Ca(2+) channels.
Jointly Sparse Signal Recovery via Deep Auto-Encoder and Parallel Coordinate Descent Unrolling (2020)

In this paper, utilizing techniques in compressed sensing, parallel optimization and deep learning, we propose a model-driven approach to jointly design the common measurement matrix and GROUP LASSO-based jointly sparse signal recovery method for complex sparse signals, based on the standard auto-encoder structure for real numbers. The encoder achieves noisy linear compression for jointly sparse signals, with a common measurement matrix. The GROUP LASSO-based decoder realizes jointly sparse signal recovery based on an iterative parallel-coordinate descent (PCD) algorithm which is proposed to solve GROUP LASSO in a parallel manner. In particular, the decoder consists of an approximation part which unfolds (several iterations of) the proposed iterative algorithm to obtain an approximate solution of GROUP LASSO and a correction part which reduces the difference between the approximate solution and the actual jointly sparse signals. The proposed model-driven approach achieves higher recovery accuracy with less computation time than the classic GROUP LASSO method, and the gain significantly increases in the presence of extra structures in sparse patterns. The common measurement matrix obtained by the proposed model-driven approach is also suitable for the classic GROUP LASSO method. We consider an application example, i.e., channel estimation in Multiple-Input Multiple-Output (MIMO)-based grant-free random access which is proposed to support massive machine-type communications (mMTC) for Internet of Things (IoT). By numerical results, we demonstrate the substantial gains of the proposed model-driven approach over GROUP LASSO and AMP when the number of jointly sparse signals is not very large.
High-Resolution Solid-State Heteronuclear Correlation NMR for Quadrupolar and Spin-1/2 Nuclei (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHigh-Resolution Solid-State Heteronuclear Correlation NMR for Quadrupolar and Spin-1/2 NucleiT. P. Jarvie, R. M. Wenslow, and K. T. MuellerCite this: J. Am. Chem. Soc. 1995, 117, 1, 570–571Publication Date (Print):January 1, 1995Publication History Published online1 May 2002Published inissue 1 January 1995https://doi.org/10.1021/ja00106a081RIGHTS & PERMISSIONSArticle Views166Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alertsclose Get e-Alerts
Cataract formation and prevention (2004)

Cataract, a leading cause of blindness worldwide, is a multifactorial eye disease. In developing countries the incidence of cataract among young generations is not uncommon due to malnutrition, excess exposure to ultraviolet radiation and so on. In developed countries, age-related cataract affecting the population over 65 years of age is a major concern. Oxidative stress was suggested to inflict damage to the lens and induce opacification, and a variety of antioxidant nutrients were tested for the prevention or delay of cataract development. Although promising results were obtained in animal studies of various antioxidants, epidemiological studies on human populations do not seem to support their protective effects unequivocally. It is unlikely that age-related cataract in man, similar to the ageing process itself, will be prevented or delayed by therapeutic drugs in the foreseeable future. At present, keeping a health-conscious life style (i.e., no smoking) may be the most effective and least expensive strategy to prevent the onset of age-related cataract.
Targeting Fibroblast Growth Factor Receptor (FGFR) with BGJ398 in a Gastric Cancer Model. (2015)

Efficacy of FGFR inhibition is dependent on FGFR1 and FGFR2IIIc expression in GC models.