gebhart/patrepeval huggingface dataset:
Mechanismenentwicklung eines Assistenzsystems für die oberen Extremitäten (2018)

In diesem Beitrag werden mobile Assistenzsysteme, sog. Exoskelette, mit ihren charakteristischen Eigenschaften vorgestellt. Schwerpunkte bilden die Entwicklung der Mechanik für die Nachbildung der menschlichen Bewegung und das Antriebssystem. Auf Grundlage der menschlichen Anatomie, mit Bezug zum Schultergürtel, Schultergelenk und Ellenbogengelenk, wird ein Mechanismus entwickelt, der die Armbewegung beim Heben, Halten und Tragen von Lasten nachbilden kann. Weiterführend wird die Entwicklung eines aktiven Antriebssystems für die Unterstützung der zuvor genannten Aufgaben beschrieben. Für die Auslegung werden Richtwerte der Bundesanstalt für Arbeitsschutz und Arbeitsmedizin (BAuA) herangezogen. Der Einsatz pneumatischer Muskeln als Aktuator bringt Vorteile hinsichtlich eines hohen spezifischen Arbeitsvermögens mit sich. Ein Nachteil ist jedoch die charakteristisch nichtlineare Kraft-Kontraktionskennlinie. Es folgt eine Beschreibung für die ungleichmäßige Übersetzung pneumatischer Muskeln mit einem Bandmechanismus. Die verwendete Methode gestattet nicht nur eine Kompensation der nachteiligen, degressiven Kraftkennlinie. Sie erlaubt darüber hinaus die anwendungsspezifische Veränderung des Arbeitskennfeldes. Abschließend erfolgt die Überführung des Bandmechanismus in eine zweistufige Übersetzung, welche die Voraussetzungen pneumatischer Muskeln für den Einsatz in mobilen Anwendungen verbessert.
The Inevitable Application of Big Data to Health Care (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Synthesis of Vitisin A & D: Thermal Isomerization Enabled by a Persistent Radical Equilibrium (2019)

The total synthesis of oligomer natural products derived from resveratrol has been achieved through a putative biogenetic bond migration from a presumed common intermediate in a divergent biosynthetic pathway.
The type IV pilin PilA couples surface attachment and cell cycle initiation in Caulobacter crescentus (2019)

Understanding how bacteria colonize surfaces and regulate cell cycle progression in response to cellular adhesion is of fundamental importance. Here, we used transposon sequencing in conjunction with FRET microscopy to uncover the molecular mechanism how surface sensing drives cell cycle initiation in Caulobacter crescentus . We identified the type IV pilin protein PilA as the primary signaling input that couples surface contact to cell cycle initiation via the second messenger c-di-GMP. Upon retraction of pili filaments, the monomeric pilin reservoir in the inner membrane is sensed by the 17 amino-acid transmembrane helix of PilA to activate the PleC-PleD two component signaling system, increase cellular c-di-GMP levels and signal the onset of the cell cycle. We termed the PilA signaling sequence CIP for cell cycle initiating pilin peptide. Addition of the chemically synthesized CIP peptide initiates cell cycle progression and simultaneously inhibits surface attachment. The broad conservation of the type IV pili and their importance in pathogens for host colonization suggests that CIP peptide mimetics offer new strategies to inhibit surface-sensing, prevent biofilm formation and control persistent infections. Significance Statement Pili are hair-like appendages found on the surface of many bacteria to promote adhesion. Here, we provide systems-level findings on a molecular signal transduction pathway that interlinks surface sensing with cell cycle initiation. We propose that surface attachment induces depolymerization of pili filaments. The concomitant increase in pilin sub-units within the inner membrane function as a stimulus to activate the second messenger c-di-GMP and trigger cell cycle initiation. Further-more, we show that the provision of a 17 amino acid synthetic peptide corresponding to the membrane portion of the pilin sub-unit mimics surface sensing, activates cell cycle initiation and inhibits surface attachment. Thus, synthetic peptide mimetics of pilin may represent new chemotypes to control biofilm formation and treat bacterial infections.
Vascular Malformation Enlargement During Menopause (2018)

Vascular malformations enlarge overtime, particularly during adolescence when follicle-stimulating hormone (FSH) rises. Lesions contain the receptor for follicle-stimulating hormone. FSH also becomes elevated during menopause. We present a patient with a venous malformation of the lip that presented for the first time after she entered menopause which was temporally related to a significant increase in her serum FSH levels that were measured. This observation supports the hypothesis that FSH might influence the pathophysiology of vascular malformations.
Cytochrome P-450 inhibitors alter afferent arteriolar responses to elevations in pressure (1994)

The present study evaluated the effects of cytochrome P-450 inhibitors on the response of the renal microvasculature to changes in renal perfusion pressure and on autoregulation of glomerular capillary pressure using the rat juxtamedullary nephron microvascular preparation perfused in vitro with a cell-free perfusate containing 5% albumin. The basal diameters of the proximal and distal afferent arterioles averaged 28 +/- 1 (n = 32) and 18 +/- 1 micron (n = 23), respectively, at a control perfusion pressure of 80 mmHg. The diameters of these vessels decreased by 8% when perfusion pressure was elevated from 80 to 160 mmHg. After addition of cytochrome P-450 inhibitors (either 17-octadecynoic acid, 20 microM; 7-ethoxyresorufin, 10 microM; or miconazole, 20 microM) to the perfusate, the diameters of the proximal and distal afferent arterioles increased by 6% in response to the same elevation in perfusion pressure. Control glomerular capillary pressure averaged 43 +/- 1 mmHg (n = 32) at a renal perfusion pressure of 80 mmHg and increased by only 9 +/- 1 mmHg when perfusion pressure was elevated to 160 mmHg. Autoregulation of glomerular capillary pressure was impaired after addition of the cytochrome P-450 inhibitors, and it increased by 18 +/- 2 mmHg when perfusion pressure was varied over the same range. These results indicate that cytochrome P-450 inhibitors attenuate the vasoconstrictor response of afferent arterioles to elevations in renal perfusion pressure and impair autoregulation of glomerular capillary pressure, suggesting a possible role for cytochrome P-450 metabolites of arachidonic acid in these responses.
Investigational Approaches to Articular Cartilage Preservation (1983)

A brief review of articular cartilage preservation identifies several directions and concerns for modern investigators. First, storage of intact cartilage in such solutions as alcohol, merthiolate, plasma, and saline may not be as good as storage in air. Second, viable cartilage appears to fare better than nonviable cartilage after transplantation. Third, freezing of isolated cartilage cells appears to be a satisfactory method for preserving viability, but the same may not be true for cartilage tissue slices, slivers, or explants. Fourth, tissue culture of slices seems to provide excellent preservation of cells in their matrix. Fifth, freezing of intact cartilage presents problems of water diffusion, as well as penetration of cryopreservative. Extremely slow freezing may provide an answer to these problems. Sixth, transplantation of isolated chondrocytes into cartilage defects does not seem to provide regeneration of articular cartilage, but transplantation of slices or larger pieces may restore a more normal appearance to the joint surface. Further investigation is obviously necessary and should continue to provide information and knowledge toward the goal of successful preservation of functional articular cartilage.
Inter-vehicle communication: recent developments at Ohio State University (2003)

In this paper we present an overview of recent developments on inter-vehicle communication at the Ohio State University. This activity addresses different aspects of human-vehicle, vehicle-vehicle and vehicle-base station-vehicle connections. In this paper, we review the utility of, and concentrate on vehicle-vehicle communication.
Fine-tuning Large Enterprise Language Models via Ontological Reasoning (2023)

Large Language Models (LLMs) exploit fine-tuning as a technique to adapt to diverse goals, thanks to task-specific training data. Task specificity should go hand in hand with domain orientation, that is, the specialization of an LLM to accurately address the tasks of a given realm of interest. However, models are usually fine-tuned over publicly available data or, at most, over ground data from databases, ignoring business-level definitions and domain experience. On the other hand, Enterprise Knowledge Graphs (EKGs) are able to capture and augment such domain knowledge via ontological reasoning. With the goal of combining LLM flexibility with the domain orientation of EKGs, we propose a novel neurosymbolic architecture that leverages the power of ontological reasoning to build task- and domain-specific corpora for LLM fine-tuning.
A Study of Microstrip Antennas for Multiple Band and High Frequency Operations. (1986)

This report consists of four parts. Part I is on an Efficient Analysis of Infinite Microstrip Arrays on Electricity Thick Substrates. The emphasis is placed on a numerically efficient method. The analysis also includes the case of infinite arrays with printed dipoles. Part II is an extension of the previous work on multiple port microstrip antennas. Experiments were carried out, which showed that this improved theory could predict the loading effect at the second port at the resonant frequency of the input port very accurately. Part III is devoted to the theory and experiment of single element dual-frequency microstrip antennas. The main objective is to achieve a dual-frequency operation for the same linear polarization with a single element fed at one port. This is discussed in Part IV. Keywords: Periodic Green's Functions, and Multipole-Port Microstrip Antennas.
Review. Journal de voyage de Michel de Montaigne. Rigolot, Francois (ed.) (1994)

Journal Article REVIEWS Get access Journal de voyage de Michel de Montaigne. Édition présentée, établie et annotée FRANÇOIS par RIGOLOT. Paris, PUF, 1992. xxxvi + 374 pp. Pb195 F. WES WILLIAMS WES WILLIAMS NEW COLLEGEOXFORD Search for other works by this author on: Oxford Academic Google Scholar French Studies, Volume XLVIII, Issue 1, January 1994, Page 91, https://doi.org/10.1093/fs/XLVIII.1.91 Published: 01 January 1994
Antibodies to Variant Antigens on the Surfaces of Infected Erythrocytes Are Associated with Protection from Malaria in Ghanaian Children (2001)

Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a variant antigen expressed on the surface of infected erythrocytes. Each parasite genome contains about 40 PfEMP1 genes, but only 1 PfEMP1 gene is expressed at a given time. PfEMP1 serves as a parasite-sequestering ligand to endothelial cells and enables the parasites to avoid splenic passage. PfEMP1 antibodies may protect from disease by inhibiting sequestration, thus facilitating the destruction of infected erythrocytes in the spleen. In this study, we have measured antibodies in Ghanaian children to a conserved region of PfEMP1 by enzyme-linked immunosorbent assay and antibodies to variant molecules on erythrocytes infected with field isolates of P. falciparum by flow cytometry. Based on close clinical monitoring, the children were grouped into those who did (susceptible) and those who did not (protected) have malaria during the season. The prevalences of antibodies to both the conserved PfEMP1 peptide and the variant epitopes were greater than 50%, and the levels of immunoglobulin G (IgG) correlated with age. The levels of antibodies to both the conserved peptide and the variant epitopes were higher in protected than in susceptible children. After correcting for the effect of age, the levels of IgG to variant antigens on a Sudanese and a Ghanaian parasite isolate remained significantly higher in protected than in susceptible children. Thus, the levels of IgG to variant antigens expressed on the surface of infected erythrocytes correlated with protection from clinical malaria. In contrast, the levels of IgG to a peptide derived from a conserved part of PfEMP1 did not correlate with protection from malaria.
Enzyme-modified organic conducting salt microelectrode (1991)

A miniaturized enzyme-modified electrode has been constructed and evaluated. The tip of a capillary-encased, carbon-fiber electrode is recessed, and tetrathiafulvalene-tetracyanoquinodimethane crystals are electrochemically deposited in the recessed tip. Flavoenzymes are placed in the recess by cross-linking with glutaraldehyde. The specific enzymes used are glucose oxidase to form a microbiosensor for glucose, and a combination of acetylcholine esterase and choline oxidase to form a microbiosensor for acetylcholine. The sensor is operated in an amperometric mode with Eapp = 150 mV versus a sodium saturated calomel electrode, and the response appears to be limited by the kinetics of the enzyme reaction. The effective maximum current density for the glucose electrode is greater than 600 microA/cm2. At low concentrations of glucose, oxygen provides a significant interference by attenuating the signal. The device is simple to prepare and has a rapid response time. Interference from ascorbate has been significantly reduced by the design and by addition of a layer of ascorbate oxidase. Although not yet suitable for use in tissue, the biosensors are suitable for detection in situations where oxygen concentrations do not frequently change.
Cord Blood Transplantation: A Promising Future (1997)

Recent clinical experience has shown that cord blood is a rich source of hematopoietic stem/progenitor cells for transplantation.1 The feasibility of hematopoietic reconstitution with umbilical cord blood was first demonstrated in 1988 when a 5-year-old boy with Fanconi's anemia was cured of the hematologic manifestations of his disease by transplantation of cord blood from a newborn sister.2 Since this landmark transplant, the use of cord blood grafts has increased exponentially. Perhaps the most attractive feature of umbilical cord blood transplantation is its potential to markedly increase the availability of a human leukocyte antigen (HLA)-matched graft for a patient in need. Until recently, bone marrow has been the usual source of hematopoietic cells for transplantation. Unfortunately, the high degree of polymorphism in the HLA system, combined with the inconvenience, risk, and pain associated with marrow donation, have made it difficult to obtain a matched marrow graft when needed. Each year approximately 7000 persons in the United States seek a donor for allogeneic bone marrow transplantation, but a suitable match is found for only about 25%. The problem is particularly severe for certain ethnic minorities, despite efforts to recruit potential unrelated donors from these populations.

In contrast to bone marrow, the harvesting of umbilical cord blood is a simple, noninvasive procedure compatible with routine obstetric practice. Cord blood, previously discarded as medical waste, is obtained for transplantation by cannulating the umbilical vein …
SM9 Digital Signature with Non-repudiation (2020)

SM9 is an identity-based cryptography algorithm published by the State Cryptography Administration of China. With SM9, a user's private key for signing is generated by a central system called key generation center (KGC). When the owner of the private key wants to shirk responsibility by denying that the signature was generated by himself, he can claim that the operator of KGC forged the signature using the generated private key. To address this issue, in this paper, two schemes of SM9 digital signature with non-repudiation are proposed. With the proposed schemes, the user's private key for signing is collaboratively generated by two separate components, one of which is deployed in the private key service provider's site while the other is deployed in the user's site. The private key can only be calculated in the user's site with the help of homomorphic encryption. Therefore, only the user can obtain the private key and he cannot deny that the signature was generated by himself. The proposed schemes can achieve the non-repudiation of SM9 digital signature.
Wheel slip control of ABS using ER valve pressure modulator (2004)

This paper presents a wheel slip control via sliding mode controller for a new anti-lock brake system (ABS) of a passenger vehicle using electrorheological (ER) valve pressure modulator. The principal design parameters of the ER valves and hydraulic booster are appropriately determined by considering braking pressure variation during ABS operation. An electrically controllable pressure modulator using the ER valves is then constructed and its governing equations are derived. Subsequently, the pressure control performance of the new pressure modulator is experimentally evaluated. The governing equations of motion for a quarter car wheel model are derived and the sliding mode controller is formulated for wheel slip control. Hardware in the loop simulation (HILS) for braking performance evaluation is undertaken in order to demonstrate the effectiveness of the proposed ABS associated with the ER valve pressure modulator.
Cross-phase modulation in fiber links with multiple optical amplifiers and dispersion compensators (1996)

We have theoretically and experimentally investigated the cross-phase modulation (XPM) effect in optical fiber links with multiple optical amplifiers and dispersion compensators. Our theory suggests that the XPM effect can be modeled as a phase modulator with inputs from the intensity of copropagating waves. The frequency response of the phase modulator corresponding to each copropagating wave depends on fiber dispersion, wavelength separation, and fiber length. The total XPM-induced phase shift is the integral of the phase shift contributions from all frequency components of copropagating waves. In nondispersive fibers, XPM is frequency-independent; in dispersive fibers, XPM's frequency response is approximately inversely proportional to the product of frequency, fiber dispersion, and wavelength separation. In an N-segment amplified link, the frequency response of XPM is increased N-fold, but only in very narrow frequency bands. In most other frequency bands, the amount of increase is limited and almost independent of N. However, in an N-segment amplified link with dispersion compensators, the frequency response of XPM is increased N-fold at all frequencies if the dispersion is compensated for within each fiber segment. Thus, the XPM-induced phase shift is smaller in systems employing lumped dispersion compensation than in systems employing distributed dispersion compensation.
PSF interlaboratory comparison (1982)

Two experiments for interlaboratory verification of radiometric analysis methods have been conducted with dosimeters irradiated in the Oak Ridge Research Reactor (ORR) Poolside Facility (PSF) Surveillance Dosimeter Measurement Facility (SDMF). In a preliminary analysis of data supplied by the six participants, biases as large as 60% were observed which could lead to errors of this general magnitude in reported surveillance capsule fluence values. As a result of these comparisons, problems were identified and the spread in final values was greatly reduced. Relative agreement among the final results reported by four of the laboratories now appears to be satisfactory (the non-fission dosimeter results generally falling within +-5% and the fission dosimeter results within +-10%), but improvement is required in order to routinely meet Reactor Vessel Material Surveillance Program goals.
Elucidating the Role of Viral Non-structural Proteins on the Morphogenesis of Arterivirus Replication Structures (2013)

Extended abstract of a paper presented at Microscopy and Microanalysis 2013 in Indianapolis, Indiana, USA, August 4 – August 8, 2013.
Training program at medical school of Chieti, Italy. (2006)

We describe the changes in medical training program offered at the G. D'Annunzio University Medical School in Chieti-Pescara, Italy, which took place over the last decade. The new curriculum differs from the previous one in several important aspects, including limited number of students admitted to school depending on the estimated needs for physicians, obligatory class attendance, student attendance in preclinical laboratories, formative credits as a measure of student activity, and elective subjects. Furthermore, all medical graduates are allowed to take the State exam to obtain the licence to practice, which was not the case previously. As a result of these major changes, a higher number of students graduates in due time. The changes made in the medical education curriculum in Italy have enabled Italian medical graduates to work in European Community Hospitals, because their medical degree is recognized in other EU countries. The main motif that drives the Medical School in Chieti-Pescara is the achievement of high quality in medical education and biomedical research by creating as strong a relationship between education and research as possible.
Joint Demosaicing and Chromatic Aberration Correction of Images Using Neural Networks. (2019)

Typical colour digital cameras have a single sensor with a colour filter array (CFA), each pixel capturing a single channel (red, green or blue). A full RGB colour output image is generated by demosaicing (DM), i.e. interpolating to infer the two unobserved channels for each pixel. The DM approach used can have a significant effect on the quality of the output image, particularly in the presence of common imaging artifacts such as chromatic aberration (CA). Small differences in the focal length for each channel (lateral CA) and the inability of the lens to bring all three channels simultaneously into focus (longitudinal CA) can cause objectionable colour fringing artifacts in edge regions. These artifacts can be particularly severe when using low-cost lenses. We propose to use a set of simple neural networks to learn to jointly perform DM and CA correction, producing high quality colour images subject to severe CA as well as image noise. The proposed neural network-based joint DM and CA correction produces a significant improvement in image quality metrics (PSNR and SSIM) compared the baseline edge-directed linear interpolation approach preserving image detail and reducing objectionable false colour and comb artifacts. The approach can be applied in the production of high quality images and video from machine vision cameras with low cost lenses, thus extending the viability of such hardware to visual media production.