gebhart/patrepeval huggingface dataset:
The complement system in age-related macular degeneration (2021)

Age-related macular degeneration (AMD) is a chronic and progressive degenerative disease of the retina, which culminates in blindness and affects mainly the elderly population. AMD pathogenesis and pathophysiology are incredibly complex due to the structural and cellular complexity of the retina, and the variety of risk factors and molecular mechanisms that contribute to disease onset and progression. AMD is driven by a combination of genetic predisposition, natural ageing changes and lifestyle factors, such as smoking or nutritional intake. The mechanism by which these risk factors interact and converge towards AMD are not fully understood and therefore drug discovery is challenging, where no therapeutic attempt has been fully effective thus far. Genetic and molecular studies have identified the complement system as an important player in AMD. Indeed, many of the genetic risk variants cluster in genes of the alternative pathway of the complement system and complement activation products are elevated in AMD patients. Nevertheless, attempts in treating AMD via complement regulators have not yet been successful, suggesting a level of complexity that could not be predicted only from a genetic point of view. In this review, we will explore the role of complement system in AMD development and in the main molecular and cellular features of AMD, including complement activation itself, inflammation, ECM stability, energy metabolism and oxidative stress.
INCIDENCE AND PREDICTORS OF COMPLICATIONS WITH SACRAL NEUROMODULATION (2008)

You have accessJournal of Urology1 Apr 2008INCIDENCE AND PREDICTORS OF COMPLICATIONS WITH SACRAL NEUROMODULATION Wesley M White, Ryan B Pickens, Cindy Dobmeyer-Dittrich, and Frederick A Klein Wesley M WhiteWesley M White More articles by this author , Ryan B PickensRyan B Pickens More articles by this author , Cindy Dobmeyer-DittrichCindy Dobmeyer-Dittrich More articles by this author , and Frederick A KleinFrederick A Klein More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(08)61430-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "INCIDENCE AND PREDICTORS OF COMPLICATIONS WITH SACRAL NEUROMODULATION." The Journal of Urology, 179(4S), p. 487 © 2008 by American Urological AssociationFiguresReferencesRelatedDetails Volume 179Issue 4SApril 2008Page: 487 Advertisement Copyright & Permissions© 2008 by American Urological AssociationMetricsAuthor Information Wesley M White More articles by this author Ryan B Pickens More articles by this author Cindy Dobmeyer-Dittrich More articles by this author Frederick A Klein More articles by this author Expand All Advertisement PDF downloadLoading ...
Rotational polarization of reaction products and reprojection of angular momentum (1972)

Molecular beam experiments employing electric deflection analysis of reactive scattering show that the rotational angular momentum for CsBr from the Cs + HBr reaction is strongly polarized perpendicular to the initial relative velocity vector. Similar polarization is observed for the K + HBr, Cs + HI, and Cs + CH3I reactions, but none is discernible for Cs + Br2 and Cs + CCl4. The experimental method involves comparing deflection profiles measured with the field oriented parallel and perpendicular to the plane of the reactant beams. It is shown that the difference between these profiles depends primarily on <cos2 x>, where x is the angle between the rotational angular momentum and the initial relative velocity vector. A sudden, non-adiabatic change of quantization axis corresponding classically to ‘reprojection’ plays an important role in the experiments. This process provides another measure of <cos2 x>. The values found for <cos2 x> range from ⪷0·05 for the K + HBr case to ⪷0·21 for Cs + CH3I, as compared to <cos2 x> = 0 and 1/3 for delta-function and isotropic distributions, respectively.
A survey of quality of service in IEEE 802.11 networks (2004)

Developed as a simple and cost-effective wireless technology for best effort services, IEEE 802.11 has gained popularity at an unprecedented rate. However, due to the lack of built-in quality of service support, IEEE 802.11 experiences serious challenges in meeting the demands of multimedia services and applications. This article surveys 802.11 QoS schemes, including service differentiation in the MAC layer, admission control and bandwidth reservation in MAC and higher layers, and link adaptation in the physical layer, designed to meet these challenges by providing the necessary enhancements for the required QoS. Furthermore, the article addresses issues that arise when end-to-end QoS has to be guaranteed in today's pervasive heterogeneous wired-cum-wireless networks. Among these challenges, protocol interoperability, multihop scheduling, full mobility support, and seamless vertical handoff among multiple mobile/wireless interfaces are specifically addressed.
Antioxidant and hepatoprotective effect of different extracts of Guizhencao （Herba Bidentis Bipinnatae） against liver injury in hyperlipidemia rats (2013)

Objevtive 将在 hyperlipidemia 老鼠对肝损害调查抗氧化剂和不同摘录 Guizhencao (草 Bidentis Bipinnatae ) 的 hepatoprotective 性质。老鼠被划分成 7 个组的方法，带着在各个的 10 只老鼠。老鼠除正常控制组以外与高脂肪的饮食被对待 18 个星期，然后，在两正常的老鼠控制并且当模特儿组被收到 5 mL/kg1 吗？？
Conversion of 48S translation preinitiation complexes into 80S initiation complexes as revealed by toeprinting (2002)

A method of analysis of translation initiation complexes by toeprinting has recently acquired a wide application to investigate molecular mechanisms of translation initiation in eukaryotes. So far, this very fruitful approach was used when researchers did not aim to discriminate between patterns of toeprints for 48S and 80S translation initiation complexes. Here, using cap-dependent and internal ribosomal entry site (IRES)-dependent mRNAs, we show that the toeprint patterns for 48S and 80S complexes are distinct whether the complexes are assembled in rabbit reticulocyte lysate or from fully purified individual components. This observation allowed us to demonstrate for the first time a delay in the conversion of the 48S complex into the 80S complex for beta-globin and encephalomyocarditis virus (EMCV) RNAs, and to assess the potential of some 80S antibiotics to block polypeptide elongation. Besides, additional selection of the authentic initiation codon among three consecutive AUGs that follow the EMCV IRES was revealed at steps subsequent to the location of the initiation codon by the 40S ribosomal subunit.
Functional solitare- and trans-hybrids, the synthesis, characterization, electrochemistry and reactivity of porphyrazine/phthalocyanine hybrids bearing nitro and amino functionality (2003)

We report here for the first time a new and improved approach to the complete synthesis and characterization of the unsymmetrical metallo- and metal-free phthalocyanine/porphyrazine (Pz/Pc) hybrids bearing peripheral nitro or amine functionality, H 2 [ Pz (n- Pr ) 6 ( BzNO 2 )] or H 2 [ Pz (n- Pr ) 4 ( BzNO 2 ) 2 ], where Bz = benzo , n-Pr = n-propyl, fused on the one or two benzenoid ring which form from the reaction of two different precursors, 3,4-bis-(n-propyl)-pyroline-2,5-diimine and 6/7-nitro-1,3,3-tricholoro isoindoline, with the base-catalyzed direct condensation method. The direct condensation method used in this study enable us to skip magnesium porphyrazine ( MgPz ) stage and limits the formation of undesired hybrid compounds when compared with cross-condensation method. Centrally metallated solitare- and trans- Pz/Pc hybrids, M [ Pz (n- Pr ) 6 ( BzNO 2 )] or M [ Pz (n- Pr ) 4 ( BzNO 2 ) 2 ]( M = Zn (II) or Mn (II)), synthesized in this study are somewhat more soluble than the free ones. Metallo Pz/Pc hybrids were prepared by treatment of free-soitare and trans hybrids with the appropriate metal salts in anhydrous solvent mixtures. We observed that the solubility of solitare- and/or trans- Pz/Pc hybrids increases after nitro-substituted Pz/Pc hybrids are reduced to amine substituted ones. The reactivity of the NH 2 group of the solitare- Zn [ Pz ( n - Pr ) 6 ( BzNH 2 )] was tested by the condensation with ferrocenecarboxyaldehyde resulting in the formation of the ferrocene-substituted hybrid. The newly synthesized compounds have been characterized by elemental analaysis, FT IR, 1 H NMR, UV-vis and MS spectroscopy. Electrochemical measurements of the complexes characterized in this study showed that the attachment of NO 2 and NH 2 moieties at the periphery makes a monitorable effect on redox properties of the macrocycle and metal center.
Laser Cooling of Relativistic Heavy Ion Beams (2006)

We report on the experimental demonstration of laser cooling of a C <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3+</sup> ion beam performed at the ESR (GSI) at an energy of E = 1.47 GeV. The decelerating laser force of one Doppler-tuned UV laser beam was counteracted by moderately bunching the beam. This versatile scheme lead to longitudinally ‘space-charge dominated’ beams with an unprecedented momentum spread of Δp/p ≈ 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">–7</sup> . Concerning beam energy and charge state of the ion, the experiment depicts an important step from the field of laser cooling of ion beams at low energies toward the laser cooling scheme proposed for relativistic beams of highly charged heavy ions at the future GSI facility FAIR.
TeraPHY: A Chiplet Technology for Low-Power, High-Bandwidth in-Package Optical I/O (2019)

In this article, we present TeraPHY, a monolithic electronic-photonic chiplet technology for low power and low latency, multi-Tb/s chip-to-chip communications. Integration of the TeraPHY optical technology with open source advanced interconnect bus interface enables communication between chips at board, rack, and row level at the energy and latency cost of in-package interconnect. This enables the design of logically connected but physically separated large-scale and high-performance digital systems. The copackaging integration approach is demonstrated by integrating the TeraPHY die into the Intel Stratix10 FPGA multichip package.
RFID Handbook: Radio-Frequency Identification Fundamentals and Applications (2000)

Differentiation of RFID systems fundamentals of RFID systems physical basics frequency ranges and regulations coding and modulation data integrity cryptography standards architecture of electronic carriers readers production of transponders and contactless smart cards applications of RFID systems market guide.
Comparative analysis of infrasonic cardiac signals (2009)

We have studied and compared three different signals of the same category of infrasonic cardiac signals together; namely, SCG, ULF-BCG and EMFIT recordings. The results demonstrate interesting similarities and differences between these signals and help us to understand some of the mechanisms behind the genesis of these waves. For instance, it was demonstrated that the rapid systolic ejection wave on SCG corresponds to similar waves on the other two signals which further confirms its origin to be the rush of blood in the aorta.
Evaluating the impact of sample storage, handling, and technical ability on the decay and recovery of SARS-CoV-2 in wastewater (2022)

Wastewater based epidemiology (WBE) is useful for tracking and monitoring the level of disease prevalence in a community and has been used extensively to complement clinical testing during the current COVID-19 pandemic. Despite the numerous benefits, sources of variability in sample storage, handling, and processing methods can make WBE data difficult to generalize. We performed an experiment to determine sources of variability in WBE data including the impact of storage time, handling, and processing techniques on the concentration of SARS-CoV-2 in wastewater influent from three wastewater treatment plants (WWTP) in North Carolina over 19 days. The SARS-CoV-2 concentration in influent samples held at 4°C did not degrade significantly over the 19-day experiment. Heat pasteurization did not significantly impact the concentration of SARS-CoV-2 at two of the three WWTP but did reduce viral recovery at the WWTP with the smallest population size served. On each processing date, one filter from each sample was processed immediately while a replicate filter was frozen at -80°C. Once processed, filters previously frozen were found to contain slightly higher concentrations (<0.2 log copies/L) than their immediately processed counterparts, indicating freezing filters is a viable method for delayed quantification and may even improve recovery at WWTP with low viral concentrations. Investigation of factors contributing to variability during sample processing indicated that analyst experience level contributed significantly (p<0.001) to accepted droplet generation while extraction efficiency and reverse transcription efficiency contributed significantly (p<0.05) to day-to-day SARS-CoV-2 variability. This study provides valuable practical information for minimizing decay and/or loss of SARS CoV-2 in wastewater influent while adhering to safety procedures, promoting efficient laboratory workflows, and accounting for sources of variability.
Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies (2019)

Abstract Variation in sex hormone levels has wide implications for health and disease. The genes encoding the proteins involved in steroid disposition represent key determinants of interindividual variation in steroid levels and ultimately, their effects. Beginning with metabolomic data from genome-wide association studies (GWAS), we observed that genetic variants in the orphan transporter, SLC22A24 were significantly associated with levels of androsterone glucuronide and etiocholanolone glucuronide (sentinel SNPs p-value &lt;1×10 −30 ). In cells over-expressing human or various mammalian orthologs of SLC22A24, we showed that steroid conjugates and bile acids were substrates of the transporter. Phylogenetic, genomic, and transcriptomic analyses suggested that SLC22A24 has a specialized role in the kidney and appears to function in the reabsorption of organic anions, and in particular, anionic steroids. Phenome-wide analysis showed that functional variants of SLC22A24 are associated with human disease such as cardiovascular diseases and acne, which have been linked to dysregulated steroid metabolism. Collectively, these functional genomic studies reveal a previously uncharacterized protein involved in steroid homeostasis, opening up new possibilities for SLC22A24 as a pharmacological target for regulating steroid levels. Author Summary Steroid hormones, ranging from sex steroids such as testosterone to glucocorticoids play key roles in human health and disease. Accordingly, the identification of the genes and proteins involved in their synthesis, disposition and elimination has been the subject of numerous genetic studies. We have been intrigued by recent studies demonstrating that genetic variants in or near a gene encoding SLC22A24 are strongly associated with steroid levels. SLC22A24 is an orphan transporter with no known ligands and no known biological functions. In this study, we use cellular and computational methods to show that SLC22A24 transports steroid conjugates, bile acids and other dicarboxylic acids. Based on the direction of association of a common stop codon in SLC22A24 with lower levels of steroids, our studies suggest that the transporter functions to reabsorb steroid conjugates in the kidney, a surprising finding, given that conjugation pathways generally function to polar molecules that are readily eliminated by the kidney. The absence of the transporter gene in many species and its presence in higher order primates suggest that SLC22A24 plays a specialized role in steroid homeostasis. Overall, our studies indicate that SLC22A24 functions in the reabsorption of conjugated steroids in the kidney.
Neoadjuvant FOLFIRINOX in Patients With Borderline Resectable Pancreatic Cancer: A Systematic Review and Patient-Level Meta-Analysis (2019)

This patient-level meta-analysis of BRPC patients treated with neoadjuvant FOLFIRINOX showed a favorable median OS, resection rate, and R0-resection rate. These results need to be assessed in a randomized trial.
Hybrid WDM digital trunking system for both HFC and FTTC access networks (2002)

Wavelength-division-multiplexed (WDM) systems can utilize the vast bandwidth provided by single-mode fiber (SMF). Here, we demonstrate a hybrid WDM system for digital trunking applications. Supporting heterogeneous traffic, the system can distribute QAM-modulated multichannel digital video, baseband PCM video signal, and SONET OC-192 signal that can serve both hybrid fiber/coax (HFC) and fiber-to-the-curb (FTTC) broadband access networks.
A leader election algorithm in a distributed computing system (2002)

A leader election algorithm based on the performance and the operation rate of nodes and links as proposed. The performance of the existing leader election algorithms should be improved because a distributed system pauses until a node becomes a unique leader among all nodes in the system. The pre-election algorithm that elects a provisional leader while the leader is executing is also introduced.
Effect of Roasting Sorghum and Soybeans on Gains and Digestibility (1978)

Forty Hereford × Angus crossbred calves averaging 278 kg were blocked by weight and sex and randomly assigned to the following treatments: (1) raw sorghum, raw soybeans; (2) raw sorghum, roasted soybeans; (3) roasted sorghum, raw soybeans; (4) roasted sorghum, roasted soybeans, and (5) Temper-treated sorghum with roasted soybeans. Roasting was done with a Roast-a-Tron at 138 C exit temperature, and the two concentrates were mixed to give a 13% crude protein diet fortified with minerals, and blended with 45% corn silage on a dry matter basis. The diets were full fed to the calves for 84 days. All feed was weighed daily and the animals were weighed each 2 weeks. Digestibility was measured using four sheep per diet fed at maintenance, and net energy values for maintenance and gain were calculated from the digestion data. In addition, rumen fermentation was studied by feeding four fistulated steers per diet and sampling six times after feeding the last 2 days of the 14-day period. Results of the rumen fermentation data in molar percents were: 59.4, 59.6, 61.1, 61.2 and 57.5 for acetate; 20.5, 14.0, 18.6, 18.4 and 14.3 for propionate; and 11.4, 10.9, 12.4, 12.6 and 12.5 for butyrate for diets 1 through 5, respectively. Dry matter digestibility was 66.9, 71.4, 71.5, 67.4 and 67.9%, while net energy values for maintenance and gain were 1.58, 1.00; 1.66, 1.08; 1.72, 1.13; 1.59, 1.02 Mcal/kg for the same diets. Mean daily gain for diets 1 through 5 were 1.13, 1.13, 1.18, 1.15 and 1.13 kg, respectively, while feed conversion was about 6.50 kg DM/kg gain for all diets. while rumen fermentation was different by treatment, it apparently was not enough to affect animal performance since digestibility, energy values, gain and feed conversion were not significantly different among treatments.
Fingolimod (Gilenya(R)) in Combination with an SSRI or SNRI Antidepressant in Multiple Sclerosis Patients with Mild to Moderate Depression: Design of a Phase IIIb Study (REGAIN) (P01.135) (2012)

Objective: The primary endpoint is the safety and tolerability profile of the combination of an SSRI or SNRI antidepressant with fingolimod in MS patients (expanded disability status scale (EDSS) 0–6.5) who are suffering mild to moderate depression (BDI-II 14-28). In addition, the efficacy of the combination therapy on quality of life, treatment satisfaction and other MS related sequelae will be exploratively assessed. Furthermore, in terms of health economics, the MS-specific and depression-specific use of resources will be evaluated. Background Almost half of all patients with multiple sclerosis (MS) are affected by concomitant psychological diseases, depression being most frequent (46%). The 12-month prevalence of depression in MS patients is 26%, which is three times higher than in the general population. Although some studies have shown a positive effect of selective serotonin/noradrenaline or serotonin re-uptake inhibitors (SNRIs or SSRIs, respectively), there is currently no established drug treatment of depression in MS patients. Therefore, in this open-label study, the safety and tolerability of the combination of fingolimod and an SSRI or SNRI antidepressant will be investigated in MS patients with mild to moderate depression. Design/Methods: In the REGAIN study ( R educe d E pression with G ilenya A nd SNRI/SSRI ant I depressant in MS-patie N ts) 375 patients with relapsing remitting MS and a mild to moderate depression, will be included. Patients will be pre-treated for 2 weeks with fingolimod, followed by a 16-week concomitant antidepressant treatment phase, with either an SSRI or an SNRI (Citalopram, Fluoxetine or Venlafaxine), at the discretion of the investigator, while maintaining on fingolimod therapy. After 8 and 16 weeks, the safety and tolerability of the combination therapy will be assessed. Results: Baseline demographics will be available in April 2012. Conclusions: This study will provide first-time data on the safety and tolerability of a combination therapy of fingolimod and an SSRI or SNRI antidepressant in MS patients with mild to moderate depression. Supported by: Novartis Pharma GmbH; Germany. Disclosure: Dr. Schuh has received personal compensation for activities with Novartis as an employee. Dr. Meergans has received personal compensation for activities with Novartis as an employee. Dr. Bayas has received personal compensation for activities as a investigator.
Carbon material from polyvinyl chloride as an adsorbent of 2,4-dichlorophenoxyacetic acid (2017)

The adsorption of 2,4-dichlorophenoxyacetic acid (2,4-D) as a typical herbicide from aqueous solutions on activated carbons prepared based on polyvinyl chloride by its alkaline dehydrochlorination and the subsequent heat treatment was studied. The structure of the activated carbon surface and the presence of functional groups on it were established. The kinetics of the process of adsorption was studied. The influence of activated carbon preparation conditions on the properties of the adsorbents was demonstrated.
CONFIRMATION OF VIBRATION COUPLING IN THE SYMMETRIC CH STRETCH AS REVEALED BY COHERENCE-DETECTED FTMW-IR SPECTROSCOPY OF CH$_3$OD. (2009)

Author Institution: Department of Chemistry, The University of Akron, Akron OH 44325; Department of Chemistry, University of Virginia, McCormick Rd., P.O. Box 400319, Charlottesville, VA 22904
Survivability in optical networks (2000)

Survivability, the ability of a network to withstand and recover from failures, is one of the most important requirements of networks. Its importance is magnified in fiber optic networks with throughputs on the order of gigabits and terabits per second. This article takes a look at the techniques used to achieve survivability in traditional optical networks, and how those techniques are evolving to make next-generation WDM networks survivable.