gebhart/patrepeval huggingface dataset:
Redox‐Functionalized Ligands: From Molecular Electrochemical Sensors to Nanostructured Surfaces (2006)

Abstract For Abstract see ChemInform Abstract in Full Text.
Incorporation of a Virtual Proteomics Module into the Undergraduate Analytical Curriculum (2023)

Proteomics, or the study of the set of proteins in an organism, tissue, or cell, is a rapidly growing field within bioanalytical chemistry that can be used to investigate many biological questions. However, proteomics is not fully integrated into the undergraduate chemistry curriculum because of a lack of access to expertise, the cost of required analytical instrumentation (liquid chromatography [LC] and mass spectrometry [MS]), and the time required for proteomics experiments. A virtual proteomics module was developed for flexible learning environments (i.e., in-person, hybrid, online) to introduce undergraduate Analytical Chemistry students to proteomics without the need for expensive instrumentation. This module teaches students about proteomics sample preparation and data acquisition, provides real LC-MS/MS data from unknown plasma samples for students to analyze, and provides experience with Mascot, a free online data analysis platform that can be used to identify the species of origin. The module was implemented in Introduction to Analytical Chemistry in two ways: (1) as a laboratory (online; ∼120 min) and (2) as a lecture (hybrid; ∼75 min). Students reported improved knowledge of proteomics after exposure to this module with average quiz scores increasing from 27% to 73%. In the lecture implementation, >90% of students successfully identified their unknowns, with almost 80% correctly justifying their conclusions. Additionally, students demonstrated increased interest in proteomics by formulating more complex research questions on the post-quiz (average of 40 words) than the pre-quiz (average of 18 words). This module was effective for students across majors and years and is a valuable educational tool that incorporates proteomics into the undergraduate chemistry curriculum across learning environments.
Supplemental table 1 from Dietary Emulsifier–Induced Low-Grade Inflammation Promotes Colon Carcinogenesis (2023)

&lt;p&gt;Oligonucleotides used in this study.&lt;/p&gt;
DEMOSTHENES 8 (2010)

The celebrated orators and speeches of ancient Athens have been read and enjoyed for thousands of years. Focusing on the works of three of the greatest orators in history-Demosthenes, Lysias, and Hypereides-this collection of speeches is an indispensable source for anyone interested in classical civilization and literature, political science and rhetoric. Each of the three sections-The Thirty Tyrants, Philip and Athens, and Athens Under Alexander-includes an introduction providing an historical overview of the period and each speech is preceded by its own brief introduction. Rendered in lively, readable prose, the translations capture the energy, vigor and power of the originals.
Extended and Structurally Supported Insights into Extracellular Hormone Binding, Signal Transduction and Organization of the Thyrotropin Receptor (2012)

The hormone thyrotropin (TSH) and its receptor (TSHR) are crucial for the growth and function of the thyroid gland. The TSHR is evolutionary linked with the receptors of follitropin (FSHR) and lutropin/choriogonadotropin (LHR) and their sequences and structures are similar. The extracellular region of TSHR contains more than 350 amino acids and binds hormone and antibodies. Several important questions related to functions and mechanisms of TSHR are still not comprehensively understood. One major reason for these open questions is the lack of any structural information about the extracellular segment of TSHR that connects the N-terminal leucine-rich repeat domain (LRRD) with the transmembrane helix (TMH) 1, the hinge region. It has been shown experimentally that this segment is important for fine tuning of signaling and ligand interactions. A new crystal structure containing most of the extracellular hFSHR region in complex with hFSH has recently been published. Now, we have applied these new structural insights to the homologous TSHR and have generated a structural model of the TSHR LRRD/hinge-region/TSH complex. This structural model is combined and evaluated with experimental data including hormone binding (bTSH, hTSH, thyrostimulin), super-agonistic effects, antibody interactions and signaling regulation. These studies and consideration of significant and non-significant amino acids have led to a new description of mechanisms at the TSHR, including ligand-induced displacements of specific hinge region fragments. This event triggers conformational changes at a convergent center of the LRRD and the hinge region, activating an "intramolecular agonistic unit" close to the transmembrane domain.
Supplementary Table 6 from Integrative Epigenomic Analysis Identifies Biomarkers and Therapeutic Targets in Adult B-Acute Lymphoblastic Leukemia (2023)

&lt;p&gt;XLS file - 45K, Detailed genes in the lymphoid gene sets and gene ontology terms&lt;/p&gt;
A ReRAM-based physically unclonable function with bit error rate < 0.5% after 10 years at 125°C for 40nm embedded application (2016)

This paper presents a secure application-a physically unclonable function (PUF)-that uses the physical property of resistive random access memory (ReRAM). The proposed PUF-generating method and reproducing algorithm achieves highly reliable with bit error rate (BER) <; 0.5% and reproduction exceeding 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">10</sup> times at -40 to 125°C after 10 years at 125°C and high uniqueness as evidenced by passing NIST tests. Evaluations on 40nm ReRAM test chips have demonstrated the feasibility of a scaled-down ReRAM cell enhanced with PUF.
Ability of High-Resolution Manometry to Determine Feeding Method and to Predict Aspiration Pneumonia in Patients With Dysphagia (2017)

We first established the optimal thresholds for HRM parameters to determine feeding method and predict the development of aspiration pneumonia in patients with oropharyngeal dysphagia.
Reaction of (3)-1,2-B9C2H13 with aluminum trialkyls. Synthesis of 1,2-B9C2H12AlR2 and 1,2-B9C2H11AlR complexes, with crystallographic characterization of 1,2-B9C2H11Al(C2H5) (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReaction of (3)-1,2-B9C2H13 with aluminum trialkyls. Synthesis of 1,2-B9C2H12AlR2 and 1,2-B9C2H11AlR complexes, with crystallographic characterization of 1,2-B9C2H11Al(C2H5)M. Frederick Hawthorne, David A. T. Young, Gerald R. Willey, Melvyn R. Churchill, and Arthur H. Reis Jr.Cite this: J. Am. Chem. Soc. 1970, 92, 22, 6663–6664Publication Date (Print):November 1, 1970Publication History Published online1 May 2002Published inissue 1 November 1970https://pubs.acs.org/doi/10.1021/ja00725a059https://doi.org/10.1021/ja00725a059research-articleACS PublicationsRequest reuse permissionsArticle Views96Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Die Bedeutung der Leukozyten für die vorzeitige Proteaseaktivierung in der experimentellen Pankreatitis (2007)

Die vorzeitige Proteaseaktivierung gilt als Auslöser und bestimmt den Verlauf und den Schweregrad der Pankreatitis. Die Transmigration von Leukozyten in das Pankreas beeinflusst ebenfalls den Schweregrad der Pankreatitis. Die Trypsinogen-Aktivierung in der Pankreatitis folgt einem biphasischem Verlauf mit einem Maximum nach 1 und 8 Stunden. Da für den Mechanismus der späten Trypsinogen-Aktivierung auch ein CCK-Rezeptor-unabhängiger Mechanismus in Frage kommt, haben wir die Bedeutung der Leukozyten-Transmigration für die Proteaseaktivierung in einem für das β2-Integrin CD18 deletiertem Modell sowie an Tieren, die für Neutrophile depletiert wurden, untersucht.
Carbonic anhydrases from Trypanosoma cruzi and Leishmania donovani chagasi are inhibited by benzoxaboroles (2017)

A series of 6-substituted ureido- and thioureido-benzoxaboroles were investigated as inhibitors of carbonic anhydrases from Trypanosoma cruzi (TcCA), and Leishmania donovani chagasi (LdcCA). Both enzymes were inhibited by benzoxaboroles in the micromolar range. Preferential inhibitory potency against the β-CA LdcCA versus the α-CA TcCA was observed with submicromolar inhibitory activities. Some derivatives displayed excellent inhibitory and selectivity profile over the ubiquitous and physiological relevant human off-target hCA II. This study provides a convincing opportunity to study benzoxaborole scaffold for the design of antiprotozoan potential drugs targeting the pathogen's carbonic anhydrases.
Flavorspace: A Technology for the Measurement of Fast Dynamic Changes of Flavor Release during Eating (2000)

The FLAVORSPACE method allows the measurement of fast dynamic changes of flavor components reaching the nose during eating of food. FLAVORSPACE - measurements are performed on a commercial quadrupole mass spectrometer, equipped with an APCI (Atmospheric Pressure Chemical Ionization) ion source with a modified interface (1). Typical examples show the direct correlation of perceived and measured flavor release. The flavor of fresh strawberries changes during eating within 25 seconds from fruity to green to fatty to woody, a measurable and perceived fact that consumers are normally not aware of. The oral cavity has a discriminating effect on flavor perception: the mucous membrane interacts with polar flavor compounds and mainly influences the aftertaste. During the analysis of crackers with different extraction procedures and with the FLAVORSPACE technique, an unknown mass was noted and then identified as the labile compound 2-acetyltetrahydro-pyridine by multistage mass spectrometry (MS)n. Understanding flavor perception is only possible, when we know the key flavor molecules released in the mouth and active in the nose receptors. A multidimensional approach and a critical interpretation of the analytical results are essential for progress.
Involvement of Carbohydrate Epitopes in the IgE Response of Celery–Allergic Patients (1999)

Our results demonstrate that IgE specific for CCD is common in celery-allergic patients, and can represent the major proportion of IgE against this food. alpha1, 3-fucose was confirmed to be an essential part of the IgE epitope. Immunoblotting inhibition indicated the presence of this carbohydrate determinant on multiple glycoproteins in celery extract. Although histamine release was only performed in 1 patient, our data show that proteins carrying multiple glycan units can be biologically active in patients sensitized to CCD.
Broadband mid-infrared superlattice light-emitting diodes (2017)

InAs/GaSb type-II superlattice light-emitting diodes were fabricated to form a device that provides emission over the entire 3–5 μm mid-infrared transmission window. Variable bandgap emission regions were coupled together using tunnel junctions to emit at peak wavelengths of 3.3 μm, 3.5 μm, 3.7 μm, 3.9 μm, 4.1 μm, 4.4 μm, 4.7 μm, and 5.0 μm. Cascading the structure recycles the electrons in each emission region to emit several wavelengths simultaneously. At high current densities, the light-emitting diode spectra broadened into a continuous, broadband spectrum that covered the entire mid-infrared band. When cooled to 77 K, radiances of over 1 W/cm2 sr were achieved, demonstrating apparent temperatures above 1000 K over the 3–5 μm band. InAs/GaSb type-II superlattices are capable of emitting from 3 μm to 30 μm, and the device design can be expanded to include longer emission wavelengths.
Untersuchung der aerodynamischen Schallquellen an einem Stromabnehmer für Hochgeschwindigkeitszüge im DNW mit einem akustischen Hohlspiegel-Mikrofon-System (1998)

Der Bericht beschreibt Messungen im DNW zur Lokalisierung der Schallquellen an einem originalen ADtranz-Stromabnehmer (Pantograph) mit dem akustischen Hohlspiegel-Mikrofon-System des DLR Göttingen. Die Schallquellenverteilung wurde für Anströmungsgeschwindigkeiten von 32 m/s und 64 m/s gemessen. Die Lage der Schallquellen konnte den einzelnen Konstruktionselementen des Pantographen sehr genau zugeordnet werden. Es werden zwei unterschiedliche Auswerteverfahren beschrieben. Es werden zwei unterschiedliche Auswerteverfahren beschrieben. Mit der ersten Methode wurden für beide Geschwindigkeiten mit einem Bandfilter Oktavanalysen mit den Mittelfrequenzen 1,0 kHz, 2,0 kHz, 4,0 kHz, und 8,0 kHz durchgefuehrt. Mit der zweiten Methode wurden Schmalbandanalysen der gemessenen Schallquellen durchgefuehrt. Aus diesen Schmalbandspektren wurden 1/3 Oktavanalysen und 1/12 Oktavanalysen berechnet und dargestellt.
First-principles determination of the structure of the Al/GaAs(110) surface (1982)

The structure of Al atoms deposited on the GaAs (110) surface has been studied using a first- principles pseudopotential energy minimization calculation. The lowest energy configurations are determined by minimizing the total energy of the system with respect to its structural degrees of freedom. The most stable configuration is such that Al atoms replace the second (or deeper) layer Ga atoms. At temperatures where this reaction cannot be activated, two important processes are found to exist. In the low coverage limit, atoms favor twofold sites connecting an As atom and a Ga atom (in the next zigzag chain) on the surface, forming strong chemical bonds with the substrate. At higher coverages, on the other hand, Al atoms tend to cluster and make new bonds among themselves. The chemisorption energy map over the surface has been obtained and the possible path of the migration of Al atoms for clustering is investigated.
How to increase serotonin in the human brain without drugs (2007)

For the last 4 decades, the question of how to manipulate the serotonergic system with drugs has been an important area of research in biological psychiatry, and this research has led to advances in the treatment of depression. Research on the association between various polymorphisms and depression supports the idea that serotonin plays a role, not only in the treatment of depression but also in susceptibility to depression and suicide. The research focus here has been on polymorphisms of the serotonin transporter, but other serotonin-related genes may also be involved.1–5 In the future, genetic research will make it possible to predict with increasing accuracy who is susceptible to depression. Much less attention has been given to how this information will be used for the benefit of individuals with a serotonin-related susceptibility to depression, and little evidence exists concerning strategies to prevent depression in those with such a susceptibility. Various studies have looked at early intervention in those with prodromal symptoms as well as at population strategies for preventing depression.6–11 Obviously, prevention is preferable to early intervention; moreover, although population strategies are important, they are ideally supplemented with preventive interventions that can be used over long periods of time in targeted individuals who do not yet exhibit even nonclinical symptoms. Clearly, pharmacologic approaches are not appropriate, and given the evidence for serotonin's role in the etiology and treatment of depression, nonpharmacologic methods of increasing serotonin are potential candidates to test for their ability to prevent depression.
Estimation of multipath parameters for uniform circular array (2001)

We derive a method based on channel parameter matrix for the estimation of these parameters from the estimation of the vector channel impulse response(VCIR),using knowledge of the transmitted pulse shape function.Compared with the multi dimensional MUSIC like or ESPRIT like ones,The algorithm does not need any search.It is a closed form solution,so it has slight computation burden.
Targeting diseases with genetically engineeredLactococcus lactisand its course towards medical translation (2011)

The use of the lactic acid bacterium Lactococcus lactis, primarily used in food fermentations, as therapeutic agent is no longer speculative but an imminent reality. After the successful completion of Phase I and II clinical trials in humans for the treatment of inflammatory bowel disease, an ongoing clinical trial to alleviate oral mucositis as well as the development of a pneumococcal and a flu vaccine using genetically modified L. lactis, many exciting possibilities exist to develop novel therapeutic and prophylactic biopharmaceuticals to alleviate a wide range of diseases. Here, we discuss existing characteristics of the systems currently employed and the nature of the immune responses evoked. We also discuss the criteria that are fundamental to making the systems feasible and efficient which should ultimately translate into human therapies. Finally, we examine the prospects for L. lactis to become a commercially viable therapeutic agent.
Materials modeling for advanced coating systems (2002)

A simulation-based system is currently is currently being constructed to aid in the development of advanced coating systems for laser cladding and surface alloying. The system employs loosely coupled material and process models that allow rapid determination of material compatibility over a wide range of processing conditions. The primary emphasis is on the development and identification of composite coatings for improved wear and corrosion resistance. The material model utilizes computational thermodynamics and kinetic analysis to establish phase stability and extent of diffusional reactions that may result from the thermal response of the material during virtual processing.
Expert consensus on indocyanine green fluorescence imaging for thoracoscopic lung resection (The Version 2022) (2022)

The use of the white-light thoracoscopy is hampered by the low contrast between oncologic margins and surrounding normal parenchyma. As a result, many patients with in situ or micro-infiltrating adenocarcinoma have to undergo lobectomy due to a lack of tactile and visual feedback in the resection of solitary pulmonary nodules. Near-infrared (NIR) guided indocyanine green (ICG) fluorescence imaging technique has been widely investigated due to its unique capability in addressing the current challenges; however, there is no special consensus on the evidence and recommendations for its preoperative and intraoperative applications. This manuscript will describe the development process of a consensus on ICG fluorescence-guided thoracoscopic resection of pulmonary lesions and make recommendations that can be applied in a greater number of centers. Specifically, an expert panel of thoracic surgeons and radiographers was formed. Based on the quality of evidence and strength of recommendations, the consensus was developed in conjunction with the <i>Chinese Guidelines on Video-assisted Thoracoscopy</i>, and the National Comprehensive Cancer Network (NCCN) guidelines on the management of pulmonary lesions. Each of the statements was discussed and agreed upon with a unanimous consensus amongst the panel. A total of 6 consensus statements were developed. Fluorescence-guided thoracoscopy has unique advantages in the visualization of pulmonary nodules, and recognition and resection of the anterior plane of the pulmonary segment. The expert panel agrees that fluorescence-guided thoracoscopic surgery has the potential to become a routine operation for the treatment of pulmonary lesions.
Scholarly Articles and Community and Junior College Students (2005)

Abstract Internet and communications technologies have changed the way academic research is performed. Although at first reluctant to have their students use subscription online database articles as resources for papers, faculty in community and junior colleges have embraced the new research methods. However, their need to have students use solid information sources leads them to require students to use scholarly journal articles, which are often too specific to be useful to and comprehensible for students. This article describes these shifts in detail and gives tips on how librarians can focus both faculty and students on resources that are useable and academic.
Optimal Zn-Modified Ca–Si-Based Ceramic Nanocoating with Zn Ion Release for Osteoblast Promotion and Osteoclast Inhibition in Bone Tissue Engineering (2017)

We investigated the slow release of Zn ion (Zn 2+ ) from nanocoatings and compared the in vitro response of osteoblasts (MC3T3-E1) and proosteoclasts (RAW 264.7) cultured on Ca 2 ZnSi 2 O 7 nanocoated with different Zn/Ca molar ratios on a Ti-6Al-4V (i.e., Ti) substrate to optimize cell behaviors and molecule levels. Significant morphology differences were observed among samples. By comparing with pure Ti and CaSiO 3 nanocoating, the morphology of Ca 2 ZnSi 2 O 7 ceramic nanocoatings was rough and contained small nanoparticles or aggregations. Slow Zn 2+ release from nanocoatings was observed and Zn 2+ concentration was regulated by varying the Zn/Ca ratios. The cell-response results showed Ca 2 ZnSi 2 O 7 nanocoating at different Zn/Ca molar ratios for osteoblasts and osteoclasts. Compared to other nanocoatings and Ti, sample Zn/Ca (0.3) showed the highest cell viability and upregulated expression of the osteogenic differentiation genes ALP, COL-1, and OCN. Additionally, sample Zn/Ca (0.3) showed the greatest inhibition of RAW 264.7 cell growth and decreased the mRNA levels of osteoclast-related genes OAR, TRAP, and HYA1. Therefore, the optimal Zn-Ca ratio of 0.3 in Ca 2 ZnSi 2 O 7 ceramic nanocoating on Ti had a dual osteoblast-promoting and osteoclast-inhibiting effect to dynamically balance osteoblasts/osteoclasts. These optimal Zn-Ca ratios are valuable for Ca 2 ZnSi 2 O 7 ceramic nanocoating on Ti-coated implants for potential applications in bone tissue regeneration.
Bimetallic Nickel/Ruthenium Catalysts Synthesized by Atomic Layer Deposition for Low-Temperature Direct Methanol Solid Oxide Fuel Cells (2016)

Nickel and ruthenium bimetallic catalysts were heterogeneously synthesized via atomic layer deposition (ALD) for use as the anode of direct methanol solid oxide fuel cells (DMSOFCs) operating in a low-temperature range. The presence of highly dispersed ALD Ru islands over a porous Ni mesh was confirmed, and the Ni/ALD Ru anode microstructure was observed. Fuel cell tests were conducted using Ni-only and Ni/ALD Ru anodes with approximately 350 μm thick gadolinium-doped ceria electrolytes and platinum cathodes. The performance of fuel cells was assessed using pure methanol at operating temperatures of 300-400 °C. Micromorphological changes of the anode after cell operation were investigated, and the content of adsorbed carbon on the anode side of the operated samples was measured. The difference in the maximum power density between samples utilizing Ni/ALD Ru and Pt/ALD Ru, the latter being the best catalyst for direct methanol fuel cells, was observed to be less than 7% at 300 °C and 30% at 350 °C. The improved electrochemical activity of the Ni/ALD Ru anode compared to that of the Ni-only anode, along with the reduction of the number of catalytically active sites due to agglomeration of Ni and carbon formation on the Ni surface as compared to Pt, explains this decent performance.