gebhart/patrepeval huggingface dataset:
Integrating MPC with Learning-Based and Adaptive Methods to Enhance Safety, Performance and Reliability in Automated Insulin Delivery (2020)

In this work, an adaptive-learning model predictive control (AL-MPC) framework that integrates disturbance forecasting, uncertainty quantification, learning, and recursive subspace identification is developed. The proposed technique can be used for continuous systems affected by repetitive disturbances with unknown periods. The AL-MPC integrates online learning from historical data to anticipate impending disturbances and proactively counteract their effects to an adaptive MPC. This is done by using machine learning to quantify the significant disturbances from historical data and forecast their future evolution time series. Behavior patterns of the system can be identified from historical data, and the set-point, objective function weights, and constraints of the controller can be modified in advance for the anticipated time periods of the disturbance effects. AL-MPC is used to regulate glucose concentration (GC) in people with diabetes by automated insulin delivery. Simulation results indicate that the AL-MPC can regulate the BGC 75.4% of the simulation time in the target range (70-180) mg/dL without causing any hypoglycemia and hyperglycemia events.
Effectiveness and biocompatibility of a novel biological adhesive application for repair of meniscal tear on the avascular zone (2012)

We have investigated the effectiveness and safety of a newly developed biological adhesive for repair of meniscal tear. The adhesive was composed of disuccinimidyl tartrate (DST) as a crosslinker and human serum albumin (HSA) as a hardener. To determine adequate concentration, bonding strength was measured using a tensiometer 5 min after applying the adhesive on the avascular zone tear of porcine meniscus; it was compared with the strengths of commercially available cyanoacrylate-based and fibrin-based adhesives. <i>In vivo</i> examination was performed using Japanese white rabbits, creating longitudinal tears on the avascular zone of meniscus and applying DST-HSA adhesive. Three months after operation the rabbits were sacrificed and tension test and histological evaluation were performed. Bonding strength was measured in three porcine meniscus groups: (i) only suturing, (ii) suturing after applying the adhesive on surface and (iii) suturing using an adhesive-soaked suture. The optimum concentrations were 0.1 mmol of DST and 42 w/v% of HAS. Bonding strength was greatest with cyanoacrylate-based adhesive, followed by DST-HSA adhesive, and fibrin-based adhesive. No inflammation was observed in the synovium or surrounding tissues 3 months after using the DST-HSA adhesive. Bonding strength was greatest with DST-HSA adhesive-soaked suturing group (77 ± 6 N), followed by suturing only group (61 ± 5 N) and surface adhesive application group (60 ± 8 N). The newly developed DST-HSA adhesive is considered safe and may be effective in enforcement of bonding of avascular zone tear of the meniscus.
Accelerated Irradiation Method to Study Synergy Effects in Bipolar Integrated Circuits (2008)

International audience
Development of Self-Management Scale for Kidney Transplant Recipients, Including Management of Post-Transplantation Chronic Kidney Disease (2013)

An evaluation scale is indispensable for the promotion of continuing, effective postkidney transplantation self-management behaviors. We aimed to develop and validate a new self-management scale for kidney transplant recipients to improve their long-term outcomes and prevent the recurrence of CKD complications. Two hundred and thirty-nine Japanese patients who had undergone kidney transplantation were recruited from three hospitals. The scale’s validity and reliability were evaluated using exploratory factor analysis and intraclass correlation coefficients. Scale items were selected by considering the findings of a clinical importance survey of 17 experts. Four subscales were identified by the factor analysis: “Self-monitoring” (six items), “Self-care behavior in daily living” (seven items), “Early detecting and coping with abnormalities after kidney transplantation” (four items), and “Stress management” (three items). Cronbach’s alpha coefficients for the subscales ranged from 0.61 to 0.87. A further four items with high clinical importance were added to the scale. The final scale comprised 24 items within four subscales and four single items. The intraclass correlation ranged from 0.88 to 0.95 in each subscale and the weighted kappa coefficient for the single items ranged from 0.33 to 0.72. The validity and reliability of our new self-management scale were confirmed by a patient-based field survey.
Sheet-like chiro-optical material designs based C(Y) surfaces (2017)

A spatial structure for which mirror reflection cannot be represented by rotations and translations is chiral. For photonic crystals and metamaterials, chirality implies the possibility of circular dichroism, that is, that the propagation of left-circularly polarized light may differ from that of right-circularly polarized light. Here we draw attention to chiral sheet- or surface-like geometries based on chiral triply-periodic minimal surfaces. Specifically we analyse two photonic crystal designs based on the C(Y) minimal surface, by band structure analysis and by scattering matrix calculations of the reflection coefficient, for high-dielectric contrasts.
Supplemental Figures S1-S7 from Heightening Energetic Stress Selectively Targets LKB1-Deficient Non–Small Cell Lung Cancers (2023)

&lt;p&gt;Treatment of LKB1 mutant and LKB1 wildtype NSCLC lines with phenformin, MLN0128 or combination leads to loss of cellular ATP (S1); Metabolite analysis of NSCLC human cell line expressing dox inducible 4E-BP1 4Ala protein and control vector (S2); Biomarker analysis of normal lung tissue in response to drug treatments (S3); Treatment of Kluc mice with phenformin, MLN0128 or combination does not result in therapeutic benefit (S4); Tumor burden does not decrease in response to phenformin, MLN0128 or combination therapy in Kluc mice (S5); Biomarker analysis in tumors treated with phenformin, MLN0128 or combination (S6); Biomarker analysis of mouse tumors lysates, human NSCLC cell lines and mouse embryonic fibroblasts (S7).&lt;/p&gt;
Crystallization and preliminary X-ray crystallographic analysis of hydroquinone dioxygenase fromSphingomonassp. TTNP3 (2012)

Hydroquinone dioxygenase (HQDO), a novel FeII ring-fission dioxygenase from Sphingomonas sp. strain TTNP3 which oxidizes a wide range of hydroquinones to the corresponding 4-hydroxymuconic semialdehydes, has been crystallized. The enzyme is an α2β2 heterotetramer constituted of two subunits of 19 and 38 kDa. Diffraction-quality crystals of HQDO were obtained using the sitting-drop vapour-diffusion method at 277 K from a solution consisting of 16% PEG 4000, 0.3 M MgCl2, 0.1 M Tris pH 8.5. The crystals belonged to the monoclinic space group P21, with unit-cell parameters a = 88.4, b = 125.4, c = 90.8 Å, β = 105.3°. The asymmetric unit contained two heterotetramers, i.e. four copies of each of the two different subunits related by noncrystallographic 222 symmetry. A complete data set extending to a maximum resolution of 2.5 Å was collected at 100 K using a wavelength of 0.980 Å.
Mapping Winter Crops in China with Multi-Source Satellite Imagery and Phenology-Based Algorithm (2019)

Timely and accurate mapping of winter crop planting areas in China is important for food security assessment at a national level. Time-series of vegetation indices, such as the normalized difference vegetation index (NDVI), are widely used for crop mapping, as they can characterize the growth cycle of crops. However, with the moderate spatial resolution optical imagery acquired by Landsat and Sentinel-2, it is difficult to obtain complete time-series curves for vegetation indices due to the influence of the revisit cycle of the satellite and weather conditions. Therefore, in this study, we propose a method for compositing the multi-temporal NDVI, in order to map winter crop planting areas with the Landsat-7 and -8 and Sentinel-2 optical images. The algorithm composites the multi-temporal NDVI into three key values, according to two time-windows—a period of low NDVI values and a period of high NDVI values—for the winter crops. First, we identify the two time-windows, according to the time-series of the NDVI obtained from daily Moderate Resolution Imaging Spectroradiometer observations. Second, the 30 m spatial resolution multi-temporal NDVI curve, derived from the Landsat-7 and -8 and Sentinel-2 optical images, is composited by selecting the maximal value in the high NDVI value period, and the minimal and median values in the low NDVI value period, using an algorithm of the Google Earth Engine. Third, a decision tree classification method is utilized to perform the winter crop classification at a pixel level. The results indicate that this method is effective for the large-scale mapping of winter crops. In the study area, the area of winter crops in 2018 was determined to be 207,641 km2, with an overall accuracy of 96.22% and a kappa coefficient of 0.93. The method proposed in this paper is expected to contribute to the rapid and accurate mapping of winter crops in large-scale applications and analyses.
Optically Induced Aggregation In Single Walled Carbon Nanotubes Functionalized with Bacteriorhodopsin (2015)

We report optically induced aggregation and subsequent separation of selective single-walled carbon nanotubes (SWNT) functionalized with bacteriorhodopsin in the aqueous solution. Well-dispersed, aqueous solutions of hydrophobic pristine SWNT were prepared using a biocompatible surfactant. Dispersed SWNTs were then functionalized with biologically synthesized, optically active purple membrane from Halobacterium salinarium S9. Bacteriorhodopsin is the optically active protein of the purple membrane. Charge transfer and interactions between an optically active purple membrane (PM) and nanotubes affect the stability of dispersion. Enhanced aggregation in these well-dispersed, stable solutions of SWNT were observed under a lamp with broadband visible frequency. Concentration of SWNTs shows rapid, optically induced aggregation of over 70% in 4 hours. This enhanced rate of aggregation under light was further investigated using specific band pass filters. The rate of aggregation was found to depend on the absorption band of the optically active PM. Raman spectra of the optically separated, bio-nano hybrid complexes show stable, preferential binding between the optically active PM and SWNTs of specific diameters.
Decorticate, decerebrate and opisthotonic posturing and seizures in Kenyan children with cerebral malaria (2005)

Abnormal motor posturing is a common feature of cerebral malaria in children. It is associated with features of raised intracranial pressure and recurrence of seizures, although intracranial hypertension may be the primary cause.
Cloning and nucleotide sequence of the Myxococcus xanthus lon gene: indispensability of lon for vegetative growth (1993)

The lon gene of Escherichia coli is known to encode protease La, an ATP-dependent protease associated with cellular protein degradation. A lon gene homolog from Myxococcus xanthus, a soil bacterium which differentiates to form fruiting bodies upon nutrient starvation, was cloned and characterized by use of the lon gene of E. coli as a probe. The nucleotide sequence of the M. xanthus lon gene was determined. It contains an open reading frame that encodes a 92-kDa protein consisting of 817 amino acid residues. The deduced amino acid sequence of the M. xanthus lon gene product showed 60 and 56% identity with those of the E. coli and Bacillus brevis lon gene products, respectively. Analysis of an M. xanthus strain carrying a lon-lacZ operon fusion suggested that the lon gene is similarly expressed during vegetative growth and development in M. xanthus. In contrast to that of E. coli, the M. xanthus lon gene was shown to be essential for cell growth, since a null mutant could not be isolated.
A Novel M2e Based Flu Vaccine Formulation for Dogs (2013)

The MaMV vaccine platform triggered an improved immune response directed towards the universal M2e peptide. The adjuvant OmpC increased the immune response to the M2e peptide and protection to a heterosubtypic influenza strain that harbors a different M2e peptide in a mouse model. Antibodies generated by the vaccine formulation showed cross-reactivity with M2e peptides derived from influenza strains H9N2, H5N1 and H1N1. The vaccine formulation shows a potential for commercialization of a new M2e based vaccine in dogs.
0.33 NA EUV systems for high-volume manufacturing (2021)

0.33 NA EUV scanners are being used for High Volume Manufacturing. In this paper we will give an update on the performance improvements of the NXE:3400 systems related to the lithographic performance, productivity and uptime. Finally we look at future system improvements to meet requirements for the 3 nm node and beyond.
Vascular effects of photodynamic therapy. (2002)

Photodynamic therapy (PDT) of tumours is based on a dual selectivity, i.e. preferential uptake and retention of a photosensitiser by tumours and irradiation of the tumour area with light wavelengths specifically absorbed by the photosensitiser. The photoexcited sensitiser generates highly reactive oxygen species that induce irreversible damage to neoplastic cells and vessels. Following sensitiser accumulation and irradiation, damage to sensitive sites within the microvasculature, namely to endothelial cells and the vascular basement membrane, is induced and leads to the establishment of thrombogenic sites within the vessel lumen. This initiates a physiological cascade of responses including platelet aggregation, the release of vasoactive molecules, leukocyte adhesion, increases in vascular permeability and vessel constriction. These result in tumour destruction by vascular collapse, blood flow stasis and tissue hemorrhages. Several photosensitisers are able to induce severe vasculature damage, although by variously different mechanisms. Due to its efficient vascular interactions, photodynamic treatment is also increasingly used for non-cancerous lesions. Successful application of PDT mainly for vessel occlusion and thrombosis in intimal hyperplasia, restenosis, atherosclerotic plaques, corneal and choroidal neovascularisation and port-wine stains is reported.
Trehalose Level in the Hemolymph of Heliothis virescens1 Parasitized by Campoletis sonorensis2, 3 (1976)

Journal Article Trehalose Level in the Hemolymph of Heliothis virescens Parasitized by Campoletis sonorensis, Get access D. L. Dahlman, D. L. Dahlman 4Dept. of Entomology, Univ. of Kentucky, Lexington, KY 40506. Search for other works by this author on: Oxford Academic Google Scholar S. Bradleigh Vinson S. Bradleigh Vinson 5Dept. of Entomology, Texas A&M Univ., College Station, TX 77843. Search for other works by this author on: Oxford Academic Google Scholar Annals of the Entomological Society of America, Volume 69, Issue 3, 17 May 1976, Pages 523–524, https://doi.org/10.1093/aesa/69.3.523 Published: 17 May 1976 Article history Received: 18 December 1975 Published: 17 May 1976
Quantitative High Resolution Electron Microscopy of Grain Boundaries and Comparison with Atomistic Simulations (2001)

Abstract The technique of high-resolution transmission electron microscopy (HREM) produces images that contain information about the atomic structure of the specimen. Within additional, very stringent, constraints, the HREM image can contain information about atomic structure of crystal defects, including grain boundaries and interfaces. to extract this information from the image it is necessary to compare the experimental image with a simulated image calculated based upon an atomic model of the specimen.2 in this comparison, investigators have been aided by the use of quantitative techniques. Atomistic simulations are often used to predict the atomic structure of crystal defects or to simulate the evolution of dynamic processes in crystals, e.g. radiation effects or dislocation motion and interaction. During the development of new models of interatomic interactions, the predictions of simulations are tested against experimental observations to validate new potentials. Grain boundary structure is a good test because atoms residing in the boundary experience environments (interatomic distances and angles) that are significantly different from those experienced by atoms residing in a perfect crystal lattice site.
Emotion Recognition and Adverse Childhood Experiences in Individuals at Clinical High Risk of Psychosis (2020)

Adverse experiences in childhood seem to have a significant impact on emotional processing in adult life. This information could be helpful in a therapeutic setting where both difficulties in social interactions and adverse experiences are often addressed.
Luminescent Mononuclear and Dinuclear Iridium(III) Cyclometalated Complexes Immobilized in a Polymeric Matrix as Solid-State Oxygen Sensors (1998)

Oxygen quenching of the luminescence of mononuclear and dinuclear Ir(III) cyclometalated complexes immobilized in the pPEGMA matrixes has been studied. Linear Stern-Volmer plots, even when experiments at different emission wavelengths have been performed, were evidenced. Despite the different luminescence lifetimes of the chromophores in the absence of quencher, similar Stern-Volmer slopes have been calculated. This behavior was tentatively interpreted by taking into account the size and charge of the chromophores. Increased sizes and lower charges seem to enhance the sensitivity of the systems. Such findings could be of interest for the design of new solid-state luminescent oxygen sensors with improved performance.
Abstract 3151: Quantitative measurement of Siglec-15 expression in non-small cell lung cancer and its association with PD-L1, B7-H4 and tumor infiltrating lymphocytes (2019)

Abstract Introduction: Siglecs are sialic acid-binding transmembrane receptors that regulate the functions of innate and adaptive immune system through the recognition of glycan ligands. Siglec-15 has been recently described as an immune suppressive molecule that shares molecular structure with PD-L1, but its role in NSCLC is still unknown. In this study, we determined Siglec-15 expression in three retrospective NSCLC cohorts and evaluated its association with mutation status, major clinicopathologic characteristics and survival. Experimental procedures: We used multiplexed automated quantitative immunofluorescence (QIF) to develop a validated assay for Siglec-15 measurement and used it to assess Siglec-15 expression and its association to major clinicopathologic variables and survival in three NSCLC cohorts of over 600 patients. Additionally, we investigated the correlation of Siglec-15 expression with tumor-infiltrating lymphocytes, PD-L1, B7-H3 and B7-H4 tumor expression. Results: In our study, Siglec-15 tumor positivity was found in 12.5%, 13.7% and 22.8% of NSCLC cohort patients. Siglec-15 expression was higher in EGFR mutant and EGFR/KRAS wild type tumors compared to KRAS mutants but was not associated with any other major clinicopathological characteristics. Siglec-15 followed a mutually exclusive pattern of expression with PD-L1, B7-H3 and B7-H4 (co-expression in 3.1%, 13.2% and 7.7% of the patients respectively), while high levels were not correlated with lymphocyte infiltration or T-cell activation, suggesting a different upregulation mechanism not mediated by IFN-gamma. Conclusions: Siglec-15 is a protein expressed with high frequency in NSCLC. Co-expression of Siglec-15 with PD-L1, B7-H3 and B7-H4 is relatively rare, suggesting that Siglec-15 has distinct and non-redundant features compared to other B7 family members. Citation Format: Maria Toki, Jon Zugazagoitia, Mehmet Altan, Linda Liu, Nikita Mani, Yuting Liu, Konstantinos Syrigos, Lieping Chen, Solomon Langermann, Roy Herbst, David Rimm. Quantitative measurement of Siglec-15 expression in non-small cell lung cancer and its association with PD-L1, B7-H4 and tumor infiltrating lymphocytes [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3151.
An ultrawide-band semiconductor optical amplifier having an extremely high penalty-free output power of 23 dBm achieved with quantum dots (2005)

A semiconductor optical amplifier (SOA) having a gain of >25 dB, noise figure of <5 dB, and 3-dB saturation output power of >19 dBm, over the record widest bandwidth of 90 nm among all kinds of optical amplifiers, and also having a penalty-free output power of 23 dBm, the record highest among all the SOAs, was realized by using quantum dots.
Two distinct nuclear factors bind the conserved regulatory sequences of a rabbit major histocompatibility complex class II gene. (1988)

The constitutive coexpression of the major histocompatibility complex (MHC) class II genes in B lymphocytes requires positive, trans-acting transcriptional factors. The need for these trans-acting factors has been suggested by the reversion of the MHC class II-negative phenotype of rare B-lymphocyte mutants through somatic cell fusion with B cells or T-cell lines. The mechanism by which the trans-acting factors exert their effect on gene transcription is unknown. The possibility that two highly conserved DNA sequences, located 90 to 100 base pairs (bp) (the A sequence) and 60 to 70 bp (the B sequence) upstream of the transcription start site of the class II genes, are recognized by the trans-acting factors was investigated in this study. By using the gel electrophoresis retardation assay, a minimum of two proteins which specifically bound the conserved A or B sequence of a rabbit DP beta gene were identified in murine nuclear extracts of a B-lymphoma cell line, A20-2J. Fractionation of nuclear extract through a heparin-agarose column allowed the identification of one protein, designated NF-MHCIIB, which bound an oligonucleotide containing the B sequence and protected the entire B sequence in the DNase I protection analysis. Another protein, designated NF-MHCIIA, which bound an oligonucleotide containing the A sequence and partially protected the 3' half of this sequence, was also identified. NF-MHCIIB did not protect a CCAAT sequence located 17 bp downstream of the B sequence. The possible relationship between these DNA-binding factors and the trans-acting factors identified in the cell fusion experiments is discussed.
Molecular determinants of peri‐apical targeting of inositol 1,4,5‐trisphosphate receptor type 3 in cholangiocytes (2022)

Fluid and bicarbonate secretion is a principal function of cholangiocytes, and impaired secretion results in cholestasis. Cholangiocyte secretion depends on peri-apical expression of the type 3 inositol trisphosphate receptor (ITPR3), and loss of this intracellular Ca<sup>2+</sup> release channel is a final common event in most cholangiopathies. Here we investigated the mechanism by which ITPR3 localizes to the apical region to regulate secretion. Isolated bile duct units, primary mouse cholangiocytes, and polarized Madin-Darby canine kidney (MDCK) cells were examined using a combination of biochemical and fluorescence microscopy techniques to investigate the mechanism of ITPR3 targeting to the apical region. Apical localization of ITPR3 depended on the presence of intact lipid rafts as well as interactions with both caveolin 1 (CAV1) and myosin heavy chain 9 (MYH9). Chemical disruption of lipid rafts or knockdown of CAV1 or MYH9 redistributed ITPR3 away from the apical region. MYH9 interacted with the five c-terminal amino acids of the ITPR3 peptide. Disruption of lipid rafts impaired Ca<sup>2+</sup> signaling, and absence of CAV1 impaired both Ca<sup>2+</sup> signaling and fluid secretion. Conclusion: A cooperative mechanism involving MYH9, CAV1, and apical lipid rafts localize ITPR3 to the apical region to regulate Ca<sup>2+</sup> signaling and secretion in cholangiocytes.