gebhart/patrepeval huggingface dataset:
Identification of candidate flavonoid pathway genes using transcriptome correlation network analysis in ripe strawberry (Fragaria×ananassa) fruits (2015)

New modulators of the strawberry flavonoid pathway were identified through correlation network analysis. The transcriptomes of red, ripe fruit from two parental lines and 14 of their progeny were compared, and uncharacterized transcripts matching the expression patterns of known flavonoid-pathway genes were identified. Fifteen transcripts corresponded with putative transcription factors, and several of these were examined experimentally using transient expression in developing fruits. The results suggest that two of the newly-identified regulators likely contribute to discrete nodes of the flavonoid pathway. One increases only LEUCOANTHOCYANIDIN REDUCTASE (LAR) and FLAVONOL 3'-HYDROXYLASE (F3'H) transcript accumulation upon overexpression. Another affects LAR and FLAVONOL SYNTHASE (FLS) after overexpression. The third putative transcription factor appears to be a universal regulator of flavonoid-pathway genes, as many pathway transcripts decrease in abundance when this gene is silenced. This report demonstrates that such systems-level approaches may be especially powerful when connected to an effective transient expression system, helping to provide rapid and strong evidence of gene function in key fruit-ripening processes.
Prospective Phase II Study of Gefitinib for Chemotherapy-Naïve Patients With Advanced Non–Small-Cell Lung Cancer With Epidermal Growth Factor Receptor Gene Mutations (2006)

Treatment with gefitinib alone for chemotherapy-naïve NSCLC patients with EGFR mutations could achieve a high efficacy with acceptable toxicity. To assess the proper timing of gefitinib in such patients, a subsequent randomized trial comparing gefitinib with standard chemotherapy is warranted.
Innovative, Non-stirred Bioreactors in Scales from Milliliters up to 1000 Liters for Suspension Cultures of Cells using Disposable Bags and Containers – A Swiss Contribution (2010)

Innovative mixing principles in bioreactors, for example using the rocking of a platform to induce a backwards and forwards 'wave', or using orbital shaking to generate a 'wave' that runs round in a cylindrical container, have proved to be successful for the suspension cultures of cells, especially when combined with disposable materials. This article presents an overview of the engineering characteristics when these new principles are applied in bioreactors, and case studies covering scales of operation from milliliters to 1000 liters.
Demonstration of an Inverted Stewart Platform Target-Suspension System Using Lightweight, High-Tensile Strings (2007)

This paper presents the design, development, and testing of an inverted Stewart platform for suspending and positioning targets during RF antenna and signature testing. Previous string target-support systems have used multiple-string-attachment-point configurations that do not allow the target roll or pitch to be modified during the azimuthal data collection. This presentation will discuss an in-house development of a scale model target-support system that allows for high-accuracy simultaneous target roll and pitch positioning. The inverted Stewart platform also offers unique stability of the target by damping out the torsional pendulum motion typically encountered in conventional string-support systems. In this paper, we will also discuss the advantages and disadvantages of the string-support concepts, and provide design guidance for building an inverted Stewart-platform support system.
Comparative risks of chronic inhaled corticosteroids and macrolides for bronchiectasis (2019)

Introduction Non-cystic fibrosis (CF) bronchiectasis (“bronchiectasis”) is a chronic airway disease for which little data exist to inform treatment decisions. We sought to compare the risks of respiratory infections in chronic users of inhaled corticosteroids (ICSs) versus macrolide monotherapy. Methods We identified a cohort of US Medicare enrollees with a bronchiectasis diagnosis (International Classification of Diseases, Ninth Revision, Clinical Modification code 494.0 or 494.1) between 2006 and 2014, excluding CF. We defined chronic new use as the first ≥28-day prescription of ICS therapy or macrolide monotherapy. We compared the characteristics of the exposure cohorts using standardised mean differences (SMDs) and computed a propensity score (PS) to account for treatment differences. The risks of acute exacerbation, hospitalised respiratory infection, all-cause hospitalisation and mortality were compared using PS decile-adjusted Cox regression models. Results We identified 83 589 new users of ICSs and 6500 new users of macrolides from 285 043 included Medicare enrollees with bronchiectasis. The crude incidence of hospitalised respiratory infection was 12.6 (ICS therapy) and 10.3 (macrolide monotherapy) per 100 patient-years. The PS-adjusted HRs comparing ICS with macrolide new users were 1.39 (95% CI 1.23–1.57) for hospitalised respiratory infection, 1.56 (95% 1.49–1.64) for acute exacerbation and 1.09 (95% 0.95–1.25) for mortality. Interpretation Among patients with bronchiectasis, the use of ICSs was associated with an increased risk of hospitalised respiratory infections compared with macrolide monotherapy.
Human embryonic stem cells derived from abnormal blastocyst donated by Marfan syndrome patient (2015)

Human embryonic stem cell (hESC) line was derived from abnormal blastocyst donated by Marfan syndrome patient after preimpantation genetic diagnosis (PGD) treatment. DNA sequencing analysis confirmed that the hESC line carried the heterozygous deletion mutation, c.3536delA, of FBN1 gene. Characteristic tests proved that the hESC line presented typicalmarkers of pluripotency and had the capability to formthe three germlayers both in vitro and in vivo.
Optimization of Titanium Alloy Injection Molding Process Parameters (2004)

Effects of process parameters such as injection pressure, injection speed, injection temperature, die temperature and their interaction, on the density and strength of the as-molded specimens were systematically studied by using orthogonal arrays design and statistical analysis method. The notability of process parameters was estimated and process parameters were optimized. Results indicated that injection pressure, injection temperature and their interaction had remarkable effect on strength, however, injection pressure, injection temperature, injection speed and interaction of injection pressure and die temperature, had distinguished influence on density. The density and strength increased as injection pressure increased. The density decreased as injection temperature increased, but the strength nearly keep constant at 155-160℃,then decreased sharply beyond 160℃.The density and strength reached the best values when die temperature and injection speed are 30℃ and 60% respectively. The optimized injection parameters for rectangular with a dimension of 6. 38mm × 6. 38mm × 48mm are as followings: injection pressure 100MPa,injection temperature 155℃,injection speed 60% and die temperature 30℃.
Mechanisms of CD4+ T lymphocyte cell death in human immunodeficiency virus infection and AIDS (2003)

AIDS, caused by the retroviruses human immunodeficiency virus type 1 and type 2 (HIV-1 and HIV-2), has reached pandemic proportions. Therefore, it is critical to understand how HIV causes AIDS so that appropriate therapies can be formulated. Primarily, HIV infects and kills CD4(+) T lymphocytes, which function as regulators and amplifiers of the immune response. In the absence of effective anti-retroviral therapy, the hallmark decrease in CD4(+) T lymphocytes during AIDS results in a weakened immune system, impairing the body's ability to fight infections or certain cancers such that death eventually ensues. The major mechanism for CD4(+) T cell depletion is programmed cell death (apoptosis), which can be induced by HIV through multiple pathways. Death of HIV-infected cells can result from the propensity of infected lymphocytes to form short-lived syncytia or from an increased susceptibility of the cells to death. However, the apoptotic cells appear to be primarily uninfected bystander cells and are eradicated by two different mechanisms: either a Fas-mediated mechanism during activation-induced cell death (AICD), or as a result of HIV proteins (Tat, gp120, Nef, Vpu) released from infected cells stimulating apoptosis in uninfected bystander cells. There is also evidence that as AIDS progresses cytokine dysregulation occurs, and the overproduction of type-2 cytokines (IL-4, IL-10) increases susceptibility to AICD whereas type-1 cytokines (IL-12, IFN-gamma) may be protective. Clearly there are multiple causes of CD4(+) T lymphocyte apoptosis in AIDS and therapies that block or decrease that death could have significant clinical benefit.
ChemInform Abstract: 2‐TETRAHYDROPYRIDYLINDOLE ALS HISTAMIN‐ UND SEROTONINANTAGONISTEN (1970)

Abstract Verschiedene Hydrazone (I) wurden nach Fischer zu den Indolen (II) cyclisiert, mit Methyljodid quaterniert und mit Natriumborhydrid zu (III) reduziert.
On the Performance of Service Publishing in IEEE 802.11 Multi-Access Environment (2007)

In a multi-access/service IEEE 802.11 environment, the problem of providing users with service-related information to support a correct and fast network selection is expected to become a very important issue. We present a quantitative comparison between the legacy scenario, where each user must enter a network point of access to check its service offer, and the enhanced scenario where some service-related information is broadcasted through beacons. Results confirm the effectiveness of the beacon-based approach, in terms of discovery time, server load, and bandwidth consumption
When Pestilence Prevails … Physician Responsibilities in Epidemics (2004)

The threat of bioterrorism, the emergence of the SARS epidemic, and a recent focus on professionalism among physicians, present a timely opportunity for a review of, and renewed commitment to, physician obligations to care for patients during epidemics. The professional obligation to care for contagious patients is part of a larger "duty to treat," which historically became accepted when 1) a risk of nosocomial infection was perceived, 2) an organized professional body existed to promote the duty, and 3) the public came to rely on the duty. Physicians' responses to epidemics from the Hippocratic era to the present suggests an evolving acceptance of the professional duty to treat contagious patients, reaching a long-held peak between 1847 and the 1950's. There has been some professional retrenchment against this duty to treat in the last 40 years but, we argue, conditions favoring acceptance of the duty are met today. A renewed embrace of physicians' duty to treat patients during epidemics, despite conditions of personal risk, might strengthen medicine's relationship with society, improve society's capacity to prepare for threats such as bioterrorism and new epidemics, and contribute to the development of a more robust and meaningful medical professionalism.
On the Preparation and Characterization of Standard Materials for Natural Human Proinsulin and C-peptide (1978)

The preparation and characterization of intact native human proinsulin and C-peptide to serve as reference standards in immunologic and biologic assays is described. The major difficulty encountered in the preparation of human proinsulin from crystalline human insulin is the rather low yield (0.08 per cent), which may be due to postmortem autolysis in the pancreatic specimens. Under such circumstances, minor degrees of contamination of batches by fresh pancreases from other species, such as cows or pigs, may be magnified considerably. Such contamination can be readily detected with various currently available proinsulin- or C-peptide-specific antisera. Autolysis before or during preparation may also affect the yields and quality of human C-peptide preparations. Some of these C-peptide by-products are described, along with methods for their purification and characterization.
EEG reveals brain network alterations in chronic aphasia during natural speech listening (2023)

Abstract Aphasia is a common consequence of a stroke which affects language processing. In search of an objective biomarker for aphasia, we used EEG to investigate how functional network patterns in the cortex are affected in persons with post-stroke chronic aphasia (PWA) compared to healthy controls (HC) while they are listening to a story. EEG was recorded from 22 HC and 27 PWA while they listened to a 25-min-long story. Functional connectivity between scalp regions was measured with the weighted phase lag index. The Network- Based Statistics toolbox was used to detect altered network patterns and to investigate correlations with behavioural tests within the aphasia group. Differences in network geometry were assessed by means of graph theory and a targeted node-attack approach. Group-classification accuracy was obtained with a support vector machine classifier. PWA showed stronger inter-hemispheric connectivity compared to HC in the theta-band (4.5-7 Hz), whilst a weaker subnetwork emerged in the low-gamma band (30.5-49 Hz). Two subnetworks correlated with semantic fluency in PWA respectively in delta- (1-4 Hz) and low-gamma-bands. In the theta-band network, graph alterations in PWA emerged at both local and global level, whilst only local changes were found in the low-gamma-band network. As assessed with the targeted node-attack, PWA exhibit a more scale-free network compared to HC. Network metrics effectively discriminated PWA and HC (AUC = 83%). Overall, we showed for that EEG-network metrics are effective biomarkers to assess natural speech processing in chronic aphasia. We hypothesize that the detected alterations reflect compensatory mechanisms associated with recovery.
Synthesis and cation-extraction study of lithium-selective chromogenic 14-crown-4 derivatives (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and cation-extraction study of lithium-selective chromogenic 14-crown-4 derivativesKeiichi Kimura, Mutsuo Tanaka, Shinichi Iketani, and Toshiyuki ShonoCite this: J. Org. Chem. 1987, 52, 5, 836–844Publication Date (Print):March 1, 1987Publication History Published online1 May 2002Published inissue 1 March 1987https://pubs.acs.org/doi/10.1021/jo00381a023https://doi.org/10.1021/jo00381a023research-articleACS PublicationsRequest reuse permissionsArticle Views434Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Intratumoral Injection of Lipopolysaccharide Causes Regression of Subcutaneously Implanted Mouse Glioblastoma Multiforme (2001)

Intratumoral injections of LPS caused dramatic regression of subcutaneously implanted delayed brain tumor cell mouse gliomas. Investigation of this antitumoral effect may improve treatment responses for patients with malignant gliomas.
Luminescent Coordination Glass: Remarkable Morphological Strategy for Assembled Eu(III) Complexes (2015)

Syntheses of novel luminescent Eu(III) coordination glasses 1 ([Eu(hfa)3(o-dpeb)]2), 2 ([Eu(hfa)3(m-dpeb)]3), and 3 ([Eu(hfa)3(p-dpeb)]n) are reported. They are composed of Eu(III) ions, hexafluoroacetylacetonato (hfa) ligands, and unique bent-angled phosphine oxide (o-, m-, p-dpeb) ligands with ethynyl groups. Their coordination structures and glass formability are dependent on the regiochemistry of substitution in regard to the internal benzene core. Single-crystal X-ray analyses and DFT calculation reveals dinuclear, trinuclear, and polymer structures for Eu(III) coordination glasses 1, 2, and 3, respectively. Those compounds show characteristic glass-transition (Tg = 25-96 °C) and strong luminescence properties (ΦLn = 72-94%).
Logic-based policy engineering in distributed authorization (2001)

This dissertation work started with the desire to solve the distributed authorization problems in open and large computer networks. During the initial investigation, we learned that by using certificate technologies, authorization localization could be achieved. However, research on these technologies is mostly focused on delegation algorithms. More fundamental issues such as authorization policy generation need to be explored and systematic approaches need to be incorporated with the current technologies in order to establish a complete prevention mechanism for the purpose. 
During our further research, we noticed that logic programming is a useful tool for implementing authorization policies. The logic system can play dual roles including knowledge representation as well as the high level specification of a secure authorization system. Although logic programming and knowledge representation have been developed for more than twenty years, their logic and languages still cannot fully support our authorization representation and reasoning. Therefore we developed an authorization logic model based on division of authorization domain to explain authorization policy behaviors. In addition, by extending the general software engineering approach, including formal specification, verification, testing, and measurement, we established a policy engineering approach suitable for generating authorization policies with logic programming system. 
Finally, we have built CBASS as a test bed to experiment on policy separation and integration issues. Solutions to associate authorization policies and credentials with each programs or files, and techniques to build interfaces in the programs to connect the separated policy systems and application or system software was developed. 
The theory and experiments that have been presented and demonstrated may be used to direct the development of distributed authorization systems, particularly their policies which are the core of the entire distributed and networked computer systems in the future.
Phenotypic and Signaling Consequences of a Novel Aberrantly Spliced Transcript FGF Receptor-3 in Hepatocellular Carcinoma (2016)

Fibroblast growth factor receptor 3 (FGFR3) plays important roles in cell proliferation, differentiation, and angiogenesis. FGFR3 is abnormally upregulated in hepatocellular carcinoma (HCC), where it correlates positively with clinicopathologic index, HCC differentiation, and advanced nuclear grade. In this study, we describe an aberrantly spliced transcript of FGFR3, termed FGFR3Δ7-9, was identified as a high frequency even in HCC. FGFR3Δ7-9 lacks exons encoding the immunoglobulin-like III domain and promoted the proliferation, migration, and metastasis of HCC cells both in vitro and in vivo Coimmunoprecipation and surface plasmon resonance assays demonstrated that the binding affinity of the aberrant FGFR3Δ7-9 receptor to FGFs was significantly higher than wild-type FGFR3IIIc Furthermore, FGFR3Δ7-9 could be self-activated by homodimerization and autophosphorylation even in the absence of ligand. Finally, FGFR3Δ7-9 more potently induced phosphorylation of the ERK and AKT kinases, leading to abnormal downstream signaling through the ERK and PI3K/AKT/mTOR pathways. FGFR3Δ7-9 also upregulated the metastasis-associated molecules Snail, MMP-9, and downregulated E-cadherin, which associated directly with FGFR3Δ7-9 Thus, as a ligand-dependent or -independent receptor, FGFR3Δ7-9 exerted multiple potent oncogenic functions in HCC cells, including proliferation, migration, and lung metastatic capacity. Overall, FGFR3 mRNA missplicing in HCC contributes significantly to its malignant character, with implications for therapeutic targeting. Cancer Res; 76(14); 4205-15. ©2016 AACR.
Gan comb-drive actuators on Si substrate (2011)

Micro-electro-mechanical comb-drive actuators made of GaN crystal are studied for an integrated a tunable GaN optical device. The GaN crystal was grown on a Si substrate by metal-organic chemical vapor deposition (MOCVD) with a low-temperature buffer layer. Selectively etching the Si substrate by XeF <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> gas, the GaN thin crystal layers are self-supported in air. Due to the residual stress by the crystal growth, the freestanding GaN layer of actuator suffers from the considerable deformation depending on the growth conditions. To compensate the convex deformation, the crystallization tension of thin HfO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> film deposited on the GaN layer is used. The displacement is 1.3 μm at 70V. The fabricated GaN actuator can be useful for the monolithic integration for tunable GaN light sources.
Phase Ib Trial To Evaluate the Safety and Pharmacokinetics of Multiple Ascending Doses of Filociclovir (MBX-400, Cyclopropavir) in Healthy Volunteers (2019)

Filociclovir (MBX-400, cyclopropavir) is an antiviral agent with activity against cytomegalovirus (CMV). A phase 1, double-blind, randomized, placebo-controlled (3:1 ratio), single-center, multiple-ascending-dose trial was conducted to assess the safety, tolerability, and pharmacokinetics of filociclovir. Filociclovir (<i>n</i> = 18) or placebo (<i>n</i> = 6) was administered as a daily oral dose (100 mg, 350 mg, or 750 mg) for 7 days to normal healthy adults (ages, 25 to 65 years) who were monitored for 22 days. Safety assessments included clinical, laboratory, and electrocardiogram monitoring. Plasma and urine samplings were used to determine pharmacokinetic parameters. All study product-related adverse events were mild, most commonly gastrointestinal (17%), nervous system (11%), and skin and subcutaneous tissue (11%) disorders. One subject had reversible grade 3 elevation in serum creatinine and bilirubin, which was associated with an ∼1-log increase in plasma filociclovir exposure compared to levels for other subjects in the same (750-mg) cohort. No other serious adverse events were observed. Plasma exposures (area under the concentration-time curve from 0 to 24 h [AUC<sub>0-24</sub>]) on days 1 and 7 were similar, suggesting negligible dose accumulation. There was a sublinear increase in plasma exposure with dose, which plateaued at the daily dose of 350 mg. The amount of filociclovir recovered in the urine remained proportional to plasma exposure (AUC). Doses as low as 100 mg achieved plasma concentrations sufficient to inhibit CMV <i>in vitro</i> (This study has been registered at ClinicalTrials.gov under identifier NCT02454699.).
The Heterogeneity of Australia Antigen (1971)

Journal Article The Heterogeneity of Australia Antigen Get access George L. Le Bouvier George L. Le Bouvier From the Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Infectious Diseases, Volume 123, Issue 6, June 1971, Pages 671–675, https://doi.org/10.1093/infdis/123.6.671 Published: 01 June 1971 Article history Received: 22 March 1971 Published: 01 June 1971