gebhart/patrepeval huggingface dataset:
Liquid‐crystalline polysiloxanes with fluorene units, and related monomeric compounds (1990)

Abstract The synthesis of the liquid‐crystalline polysiloxanes, 4a , 4b , 5a , 5b with 2,7‐disubstituted fluorene units and of the related liquid‐crystalline model compounds 2 and 3 is reported. Polymers 4a , 4b , 5a , 5b were prepared from monomers 2 and 3 , respectively, and poly(hydrogenmethyl‐siloxane) (PHMS) in a polymer‐analogous reaction. The liquid‐crystalline properties of the polymers and the corresponding low‐molecular‐weight compounds 2 and 3 were characterized by differential scanning calorimetry (DSC) and polarizing microscopy. Both compounds 2 and 3 show a smectic A and a smectic E mesophase, and the resulting polysiloxanes also exhibit smectic A‐ and smectic E‐like textures but no nematic phase. The clearing point of the polymers is on the average by 100°C higher than that found for the low‐molecular‐weight compounds.
Melissa officinalis L., a valuable medicine plant: A review (2010)

Melissa officinalis L., a valuable medicinal plant in herbal medicine is native to the eastern Mediterranean Region and western Asia. The constituent of the essential oil of the plant in various climates is different, but citral (geranial and neral), citronellal, geraniol are main components. Many parameters influencing essential oil composition and yield, such as light intensity, nutrient, temperature, cultural practice genotype, plant part age, harvesting time. Lemon balm has been traditionally used for different medical purposes as tonic, antispasmodic, carminative, diaphoretic, surgical dressing for wounds, sedative-hypnotic strengthening the memory, and relief of stress induced headache, but in modern pharmacology is value in the management of mild to moderate Alzheimer’s, against migraine and rheumatism, antitumel and antioxidant activities.

	 

	Key words: Melissa officinalis, essential oil, pharmacology and antioxidant.
Hydrothermal Synthesis of Nanosized Titania Photocatalysts Using Novel Water-Soluble Titanium Complexes (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Prevalence of Zika virus neutralizing antibodies in healthy adults in Vietnam during and after the Zika virus epidemic season: a longitudinal population-based survey (2020)

Abstract Background : Between 2016 and 2019, 265 cases of Zika virus (ZIKV) infection were reported in Vietnam, predominantly in southern Vietnam. In 2016, a case of ZIKV-associated microcephaly was confirmed in the Central Highlands, and several members of the infant’s family were confirmed to be infected with ZIKV. The study aims to determine the level of immunity to ZIKV in the general population of the ZIKV epidemic region. Methods: A total of 879 serum samples were collected from 801 participants between January 2017 and July 2018, during and after the ZIKV epidemic in Vietnam. The samples were tested for anti-ZIKV immunoglobulin M (IgM) and immunoglobulin G (IgG), and anti-dengue virus (DENV) IgG antibodies using enzyme-linked immunosorbent assays (ELISA). Plaque-reduction neutralization test (PRNT) for ZIKV was performed on all samples, and for DENV on the samples that ZIKV neutralizing antibody positive. Results: A total of 83 (10.3%) participants had anti-ZIKV IgM. Of the 83, 6 were confirmed to be ZIKV antibodies positive using PRNT and anti-ZIKV IgG ELISA. Of the 718 participants who were anti-ZIKV IgM negative, a further 3 cases were confirmed as positive for antibodies against ZIKV. Of the 9 participants with ZIKV infection, 5 lived in the same village as the infant with ZIKV-associated microcephaly and the other 4 lived in 2 neighboring communes. Repeat samples were collected from the 83 ZIKV IgM positive participants 1.5 years after the first collection. No new cases of ZIKV infection were detected. In addition, 2 of 3 participants with anti-ZIKV NS1 IgG demonstrated a 4- to 8-fold increase in ZIKV neutralizing antibody titer. Conclusions: ZIKV was present in the area around Krong Buk, with the rate of ZIKV-specific antibodies was 1.1% in the community since at least 2016. While the low levels of circulation together with low seroprevalence suggests a limited outbreak in the region, the results also reflect on low levels of protective immunity to Zika within the population. These results provide a better understanding of the current ZIKV epidemic status in the region and demonstrate a need for implementation of more effective ZIKV infection control measures.
Peptide-Based Supramolecular Systems Chemistry (2021)

Peptide-based supramolecular systems chemistry seeks to mimic the ability of life forms to use conserved sets of building blocks and chemical reactions to achieve a bewildering array of functions. Building on the design principles for short peptide-based nanomaterials with properties, such as self-assembly, recognition, catalysis, and actuation, are increasingly available. Peptide-based supramolecular systems chemistry is starting to address the far greater challenge of systems-level design to access complex functions that emerge when multiple reactions and interactions are coordinated and integrated. We discuss key features relevant to systems-level design, including regulating supramolecular order and disorder, development of active and adaptive systems by considering kinetic and thermodynamic design aspects and combinatorial dynamic covalent and noncovalent interactions. Finally, we discuss how structural and dynamic design concepts, including preorganization and induced fit, are critical to the ability to develop adaptive materials with adaptive and tunable photonic, electronic, and catalytic properties. Finally, we highlight examples where multiple features are combined, resulting in chemical systems and materials that display adaptive properties that cannot be achieved without this level of integration.
Rapid Chairside Microbial Detection Predicts Endodontic Treatment Outcome (2020)

A chairside sampling method is able to predict the outcome of RCT, through the use of paper point sampling and fluorescence staining. This has reduced the prevalence of persistent infections by guiding the optimum time for obturation. ClinicalTrials.gov trial NCT03660163.
Escherichia coli identification and strain discrimination using nanosecond laser-induced breakdown spectroscopy (2007)

Three strains of Escherichia coli, one strain of environmental mold, and one strain of Candida albicans yeast have been analyzed by laser-induced breakdown spectroscopy using nanosecond laser pulses. All microorganisms were analyzed while still alive and with no sample preparation. Nineteen atomic and ionic emission lines have been identified in the spectrum, which is dominated by calcium, magnesium, and sodium. A discriminant function analysis has been used to discriminate between the biotypes and E. coli strains. This analysis showed efficient discrimination between laser-induced breakdown spectroscopy spectra from different strains of a single bacteria species.
Modeling and Analysis of Attacks and Counter Defense Mechanisms for Cyber Physical Systems (2015)

In this paper, we develop an analytical model based on stochastic Petri nets to capture the dynamics between adversary behavior and defense for cyber physical systems. We consider several types of failures including attrition failure, pervasion failure, and exfiltration failure which can happen to a cyber physical system. Using a modernized electrical grid as an example, we illustrate the parameterization process. Our results reveal optimal design conditions, including the intrusion detection interval, and the redundancy level, under which the modernized electrical grid's mean time to failure is maximized. Further, there exists a design tradeoff between exfiltration failure, attrition failure, and pervasion failure when using redundancy to improve the overall system reliability.
A hybrid substrate for a temperature-compensated surface acoustic wave filter (2009)

A hybrid substrate that is appropriate for temperature compensation of a surface acoustic wave (SAW) filter is developed. A one-port SAW resonator was fabricated on the hybrid substrate to study its electronic characteristics and thermal stability. The spurious response originating from bulk wave reflection at the layer interface was found to be sufficiently small with a relatively thin piezoelectric layer. The minimum temperature coefficient of frequency (TCF) was -8.4 ppm/°C.
A Three-Component Coupling Strategy for Tetrahydrofuran Synthesis:  Application of the Diisopropyl Tartrate Modified (E)-γ-(Dimethylphenylsilyl)allylboronate as an α,γ-Allyl Dianion Equivalent (2000)

[reaction: see text] A highly convergent three-component coupling strategy for the stereocontrolled synthesis of 2,3,5-trisubstituted tetrahydrofurans is described. After allylboration of the first aldehyde with 1, the chiral, nonracemic allylsilanes 2 are coupled with a second aldehyde or ketone with Lewis acid catalysis to give tetrahydrofurans 3 or 4 with excellent selectivity. The 2,5-stereochemistry is controlled by operating under nonchelate (e.g., 3) or chelate (e.g., 4) conditions.
Design and construction of high skew Super-T bridges (2011)

Population pharmacokinetic (pop-PK) models constructed for model-informed precision dosing often have limited utility due to the low number of patients recruited. To augment such models, an approach is presented for generating fully artificial quasi-models which can be employed to make individual estimates of pharmacokinetic parameters. Based on 72 concentrations obtained in 12 patients, one- and two-compartment pop-PK models with or without creatinine clearance as a covariate were generated for piperacillin using the nonparametric adaptive grid algorithm. Thirty quasi-models were subsequently generated for each model type, and nonparametric maximum a posteriori probability Bayesian estimates were established for each patient. A significant difference in performance was found between one- and two-compartment models. Acceptable agreement was found between predicted and observed piperacillin concentrations, and between the estimates of the random-effect pharmacokinetic variables obtained using the so-called support points of the pop-PK models or the quasi-models as priors. The mean squared errors of the predictions made using the quasi-models were similar to, or even considerably lower than those obtained when employing the pop-PK models. Conclusion: fully artificial nonparametric quasi-models can efficiently augment pop-PK models containing few support points, to make individual pharmacokinetic estimates in the clinical setting.
Cell Responses to FGFR3 Signaling: Growth, Differentiation and Apoptosis (2005)

No AccessJournal of UrologyUrological Survey: Uro-Science1 Oct 2005Cell Responses to FGFR3 Signaling: Growth, Differentiation and Apoptosis Timothy L. RatliffPh.D. Timothy L. RatliffTimothy L. Ratliff More articles by this author View All Author Informationhttps://doi.org/10.1097/S0022-5347(01)68687-7AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Cell Responses to FGFR3 Signaling: Growth, Differentiation and Apoptosis." The Journal of Urology, 174(4 Part 1), pp. 1497–1498 © 2005 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 174Issue 4 Part 1October 2005Page: 1497-1498 Advertisement Copyright & Permissions© 2005 by American Urological Association, Inc.MetricsAuthor Information Timothy L. Ratliff More articles by this author Expand All Advertisement PDF downloadLoading ...
Phase transitions and energy storage properties of some compositions in the (1−x)Li2SO4–xNa2SO4system (2014)

In the binary system (1−x)Li2SO4–xNa2SO4, the solid–solid phase transitions and energy storage properties of Li2SO4, Na2SO4, the binary compound LiNaSO4 and two eutectoids (E1: 0.726Li2SO4–0.274Na2SO4; E2: 0.03Li2SO4–0.97Na2SO4) were investigated by X-ray diffraction and differential scanning calorimetry. Li2SO4 has a solid–solid phase transition at 578 °C with the transition enthalpy 252 J g−1. The binary compound LiNaSO4 gives a slightly lower enthalpy value, 214 J g−1 and its transition temperature is clearly reduced to 514 °C. The transition enthalpy of the eutectoid E1 is maintained to 177 J g−1 and its transition temperature is further reduced to 474 °C. Li2SO4, LiNaSO4 and the eutectoid E1 are applicable phase transition materials because of their large transition enthalpies. The enthalpies of Na2SO4 and the eutectoid E2 are not very high (∼45 J g−1), but their transition temperatures are quite low (∼250 °C); thus their transition properties may be applied at such low temperatures.
Absorbable Plates for Rib Fracture Repair: Preliminary Experience (2003)

Absorbable plates produce good clinical results and are an option for rib fracture repair. Two-point fixation (screw fixation plus suture cerclage) is required. Further refinements in technique should focus on minimally invasive methods.
Efficacy and safety of 3 day versus 7 day cefditoren pivoxil regimens for acute uncomplicated cystitis: multicentre, randomized, open-label trial (2016)

Cefditoren pivoxil is safe and effective for uncomplicated cystitis, with no significant differences in clinical and microbiological efficacies between 3 and 7 day regimens.
Alteration of glomerular permeability to macromolecules induced by cross-linking of beta 1 integrin receptors. (1996)

Altered glomerular epithelial cell attachment to the glomerular basement membrane is an important pathogenetic factor in increased glomerular permeability to proteins. We have previously presented evidence that antibodies reactive with integrin matrix receptors on glomerular epithelial cells inhibit adhesion of these cells and may be involved in the production of proteinuria in vivo. Therefore, we utilized intact glomeruli in an in vitro system to directly assess the effect of anti-beta 1-integrin antibody on glomerular permeability. Permeability to albumin (Palb) was calculated from the volume response of glomeruli to a transcapillary oncotic gradient. Anti-beta 1-integrin increased Palb in a dose- and time-dependent manner. Palb was increased to 0.70 +/- 0.05 whereas normal rabbit IgG had no effect (0.10 +/- 0.04). F(ab')2 fragments of antibody increased Palb to a similar degree whereas Fab fragments had no effect (0.10 +/- 0.06). Cross-linking of Fab fragments, however, with a second antibody restored their ability to increase Palb (0.60 +/- 0.09), demonstrating the importance of integrin cross-linking in producing the observed effect. Intact, F(ab')2 and Fab fragments of anti-beta 1 antibody all inhibited adhesion of glomerular epithelial cells to fibronectin, laminin, and types I and IV collagen, although the degree of inhibition by Fab fragments was significantly less on collagens. No cytotoxic effects were observed with anti-beta 1 antibody or its fragments. These results suggest that antibodies to integrin matrix receptors on glomerular cells alter cell interactions with the glomerular basement membrane and lead to increased glomerular permeability to proteins via a process that is initiated by integrin cross-linking rather than through simple interference with cell adhesion per se.
Cationic polymerization of glycidol. Polymer structure and polymerization mechanism (1995)

Abstract Glycidol (2‐epoxy‐1‐propanol) was polymerized under the action of Lewis acids (BF 3 OEt 2, , SnCl 4 ) and protonic acids (CF 3 COOH, CF 3 SO 3 H). Polymers with number‐average molecular weights ( M̄ n ) varying from 2500 to 6000 g/mol were obtained. The structure of obtained polymers was characterized by 13 C and 29 Si NMR spectroscopy, and the amount of 1‐3 units, 1‐4 units and chain branches was determined. The structure of the polymers was related to the polymerization mechanism, especially to the contribution of activated monomer mechanism in chain growth.
Supported Ruthenium–Carbene Catalyst on Ionic Magnetic Nanoparticles for Olefin Metathesis (2014)

The Grubbs-Hoveyda ruthenium-carbene complex has been covalently immobilized on ionic magnetic nanoparticles utilizing an imidazolium salt linker. The supported catalyst exhibited excellent catalytic activity for ring-closing metathesis (RCM) and cross-metathesis (CM) in the presence of less than 1 mol % of ruthenium. The catalysts can easily be recovered magnetically and reused up to seven times with minimal leaching of ruthenium species.
Photoacoustic spectroscopy of β-hematin (2012)

Malaria affects over 200 million individuals annually, resulting in 800,000 fatalities. Current tests use blood smears and can only detect the disease when 0.1-1% of blood cells are infected. We are investigating the use of photoacoustic flowmetry to sense as few as one infected cell among 10 million or more normal blood cells, thus diagnosing infection before patients become symptomatic. Photoacoustic flowmetry is similar to conventional flow cytometry, except that rare cells are targeted by nanosecond laser pulses to induce ultrasonic responses. This system has been used to detect single melanoma cells in 10 ml of blood. Our objective is to apply photoacoustic flowmetry to detection of the malaria pigment hemozoin, which is a byproduct of parasite-digested hemoglobin in the blood. However, hemozoin is difficult to purify in quantities greater than a milligram, so a synthetic analog, known as β-hematin was derived from porcine haemin. The specific purpose of this study is to establish the efficacy of using β-hematin, rather than hemozoin, for photoacoustic measurements. We characterized β-hematin using UV-vis spectroscopy, TEM, and FTIR, then tested the effects of laser irradiation on the synthetic product. We finally determined its absorption spectrum using photoacoustic excitation. UV-vis spectroscopy verified that β-hematin was distinctly different from its precursor. TEM analysis confirmed its previously established nanorod shape, and comparison of the FTIR results with published spectroscopy data showed that our product had the distinctive absorbance peaks at 1661 and 1206 cm(-1). Also, our research indicated that prolonged irradiation dramatically alters the physical and optical properties of the β-hematin, resulting in increased absorption at shorter wavelengths. Nevertheless, the photoacoustic absorption spectrum mimicked that generated by UV-vis spectroscopy, which confirms the accuracy of the photoacoustic method and strongly suggests that photoacoustic flowmetry may be used as a tool for diagnosis of malaria infection.
Imaging electric and magnetic near field of radiating structures by infrared thermography (2019)

International audience
Two novel variants of uncertain significance in GP9 associated with Bernard–Soulier syndrome: Are they true mutations? (2017)

Bernard-Soulier syndrome (BSS) is an autosomal recessive major thrombocytopathy, the symptoms of which are mainly marked by mucocutaneous bleeding. This rare disease, initially described in the 1970s, is the result of an abnormal formation of the glycoprotein complex Ib-IX-V (GP Ib-IX-V), a platelet receptor of von Willebrand factor. A large number of mutations, sometimes involving the GP9 gene, have been described as possibly responsible for the disease. We report here the case of a BSS patient who presented with persistent thrombocytopenia (31x10<sup>9</sup>/L) and decreased surface expression of GPIb-IX-V on large platelets with anisocytosis. Thorough molecular analyses disclosed two previously unreported GP9 variants, respectively c.230T>A (p.Leu77Gln) and c.255C>A (p.Asn85Lys). Both are likely to modify the conformation of GP-IX interactions with other glycoproteins of the Ib-IX-V complex and thus proper expression of this complex on the membrane of platelets.
A comparison of foetal SAR in three sets of pregnant female models (2009)

This paper compares the foetal SAR in the HPA hybrid mathematical phantoms with the 26-week foetal model developed at the National Institute of Information and Communications Technology, Tokyo, and the set of 13-, 26- and 38-week boundary representation models produced at Rensselaer Polytechnic Institute. FDTD calculations are performed at a resolution of 2 mm for a plane wave with a vertically aligned electric field incident upon the body from the front, back and two sides from 20 MHz to 3 GHz under isolated conditions. The external electric field values required to produce the ICNIRP public exposure localized restriction of 2 W kg(-1) when averaged over 10 g of the foetus are compared with the ICNIRP reference levels.
Passive containment cooling system with hydrogen recombiner for prolonged station blackout (2019)

Beyond design basis accident scenario, where station blackout could lead to severe accident with hydrogen release, has become important after accident at Fukushima Daiichi nuclear plant. Here a passive containment cooling system (PCCS) combined with hydrogen mitigation system is suggested that will passively remove containment heat load as well as mitigate hydrogen gas generated and accumulated in the containment atmosphere during prolonged station blackout. It is proposed to make use of atmosphereic air as ultimate heat sink to reject the PCCS heat, which in turn transfers heat from the containment. In the proposed design a finned vertical tube type PCCS system submersed in pool water is considered with supply of pool water lasting three days following which airflow cools PCCS tubes for long term. The PCCS inlet flow path has a catalytic recombiner that is effective during first few days should there be any hydrogen generation and accumulation in the containment.
Cover trees for nearest neighbor (2006)

We present a tree data structure for fast nearest neighbor operations in general n-point metric spaces (where the data set consists of n points). The data structure requires O(n) space regardless of the metric's structure yet maintains all performance properties of a navigating net (Krauthgamer & Lee, 2004b). If the point set has a bounded expansion constant c, which is a measure of the intrinsic dimensionality, as defined in (Karger & Ruhl, 2002), the cover tree data structure can be constructed in O (c6n log n) time. Furthermore, nearest neighbor queries require time only logarithmic in n, in particular O (c12 log n) time. Our experimental results show speedups over the brute force search varying between one and several orders of magnitude on natural machine learning datasets.
Differential pH as a method for increasing cell potential in organic aqueous flow batteries (2017)

A semi-organic, differential pH flow battery with increased cell voltage shows stable operation for at least 30 days.
Which Stent Is Best for PCI in Saphenous Vein Grafts (2018)

For most lesions, drug-eluting stents (DES) have proven better than bare-metal stents (BMS), due to lower rates of restenosis and repeat