gebhart/patrepeval huggingface dataset:
Host permissiveness to baculovirus influences time‐dependent immune responses and fitness costs (2020)

Insects possess specific immune responses to protect themselves from different types of pathogens. Activation of immune cascades can inflict significant developmental costs on the surviving host. To characterize infection kinetics in a surviving host that experiences baculovirus inoculation, it is crucial to determine the timing of immune responses. Here, we investigated time-dependent immune responses and developmental costs elicited by inoculations from each of two wild-type baculoviruses, Autographa californica multiple nucleopolyhedrovirus (AcMNPV) and Helicoverpa zea single nucleopolyhedrovirus (HzSNPV), in their common host H. zea. As H. zea is a semi-permissive host of AcMNPV and fully permissive to HzSNPV, we hypothesized there are differential immune responses and fitness costs associated with resisting infection by each virus species. Newly molted 4th-instar larvae that were inoculated with a low dose (LD<sub>15</sub> ) of either virus showed significantly higher hemolymph FAD-glucose dehydrogenase (GLD) activities compared to the corresponding control larvae. Hemolymph phenoloxidase (PO) activity, protein concentration and total hemocyte numbers were not increased, but instead were lower than in control larvae at some time points post-inoculation. Larvae that survived either virus inoculation exhibited reduced pupal weight; survivors inoculated with AcMNPV grew slower than the control larvae, while survivors of HzSNPV pupated earlier than control larvae. Our results highlight the complexity of immune responses and fitness costs associated with combating different baculoviruses.
Myocardial fibrosis by delayed enhancement cardiovascular magnetic resonance and HCV infection in thalassemia major patients (2010)

ss Open Acce Oral presentation Myocardial fibrosis by delayed enhancement cardiovascular magnetic resonance and HCV infection in thalassemia major patients Alessia Pepe1, Antonella Meloni1, Zelia Borsellino2, Maria Chiara Dell'Amico1, Vincenzo Positano1, Caterina Borgna-Pignatti3, Aurelio Maggio4, Gennaro Restaino5, Francesco Gagliardotto2, Paolo Cianciulli6, Luciano Prossomariti7, Aldo Filosa7, Michele Centra8, Domenico D'Ascola9, Antonella Quarta10, Angelo Peluso11, Antonello Pietrangelo12, Eliana Cracolici13, Massimo Lombardi*1 and Marcello Capra2
Meditation for Major Depressive Disorder: A Systematic Review (2015)

RAND researchers conducted a systematic review that synthesized evidence from randomized controlled trials of mindfulness-based cognitive therapy — used adjunctively or as monotherapy — to assess its efficacy and safety in treating adults with major depressive disorder (MDD).
Monitoring of Chlorine Concentration in Drinking Water Distribution Systems Using an Interval Estimator (2007)

Monitoring of Chlorine Concentration in Drinking Water Distribution Systems Using an Interval Estimator This paper describes the design of an interval observer for the estimation of unmeasured quality state variables in drinking water distribution systems. The estimator utilizes a set bounded model of uncertainty to produce robust interval bounds on the estimated state variables of the water quality. The bounds are generated by solving two differential equations. Hence the numerical efficiency is sufficient for on-line monitoring of the water quality. The observer is applied to an exemplary water network and its performance is validated by simulations.
The Effect of a Thin Diffused Solute Layer on the Nucleation of Fatigue Cracks. (1975)

Small alterations in the surface conditions of Ti-6Al-4V can have significant effects on the fatigue life. A critical amount of dissolved oxygen near the surface was more effective than diffused aluminum. A combination of solute hardening, twin formation and grain boundary effects seem, at this time, to be the major controlling factor in the surface retardation of the nucleation of fatigue cracks. High vacuum will increase fatigue life greatly. The lifetime in high vacuum appears to be due to the growth of the cracks and not the nucleation process.
Neutron irradiation and annealing temperature effects of CZ-Silicon (2015)

In the present work, we have irradiated p-type CZ-silicon at two different neutron fluences, 1.98 ×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">18</sup> and 3.96 ×10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">18</sup> n/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . The optical properties and irradiation damage have been investigated using Fourier Transform Infrared spectroscopy (FTIR) and UV-VIS spectrophotometer technique at room temperature. The results show that the density of the vacancy-oxygen complex VO center (830 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> ) increases with increasing neutron fluence. Further, the creation of the divacancy defect (1.8 μm) concentration and the near edge absorption was formed after irradiation. The results from annealing indicate that near-edge absorption, VO defects disappear at 550 °C. However, another band around 825 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> was formed at the same temperature. The near-edge absorption and the band of 1.8μm have not been detected at 550 °C, and new bands near 1.4 and 1.7μm appeared. It is reasonable to assume that the two bands may be due to the divacancy consisting one or more lithium impurity atoms. The existence of these bands confirms that the transmutation of the boron to the lithium atoms can be attained in the neutron fluences available at the reactor Es Salem. It was concluded that the cluster defects induced by the neutron irradiation can be attributed to the vacancy-rich region which reordered after annealing treatment.
Post-translational processing of the leukocyte integrin alpha 4 beta 1. (1992)

The leukocyte integrin alpha 4 beta 1 (VLA-4, CD49d/CD29) is a receptor for the extracellular matrix protein fibronectin and the endothelial adhesion protein VCAM-1. We have analyzed the biosynthesis and post-translational modifications of the two subunits of this receptor complex. The alpha 4 subunit was initially synthesized as a single-chain polypeptide that underwent the formation of complex endoglycosidase H-resistant oligosaccharide side chains and which could be proteolytically cleaved into two noncovalently associated fragments. The level and rate of alpha 4 subunit cleavage was dependent on the cell studied. The T cell tumor line HPB-ALL expressed both intact and fragmented alpha 4 on the cell surface. The interleukin-2-dependent natural killer line NK 3.3 and long term interleukin-2-dependent activated T lymphocytes cleaved the alpha 4 polypeptide earlier and more efficiently than did HPB-ALL cells and did not have detectable levels of intact alpha 4 on the cell surface. The proteolysis of alpha 4 was blocked by treating cells with either the lysosomotrophic amine NH4Cl or the carboxylic ionophore monensin. The presence of complex N-linked oligosaccharides did not seem to be necessary for alpha 4 cleavage or for binding of the alpha 4 beta 1 complex to a synthetic peptide corresponding to the binding site for this receptor on fibronectin.
Diaroyl(methanato)boron Difluoride Compounds as Medium‐Sensitive Two‐Photon Fluorescent Probes (2004)

This paper evaluates the use of diaroyl(methanato)boron difluoride compounds for designing efficient fluorescent probes through two-photon absorption. Three different pathways allowing for the syntheses of symmetrical and dissymmetrical molecules are reported. The stable diaroyl(methanato)boron difluoride derivatives can be easily obtained in good yields. They exhibit a large one-photon absorption that is easily tuned in the near-UV range. Their strong fluorescence emission covers the whole visible domain. In addition to these attractive linear properties, several diaroyl(methanato)boron difluoride derivatives possess significant cross sections for two-photon absorption. The derived structure-property relationships are promising for designing new generations of molecules relying on the diaroyl(methanato)boron difluoride backbone.
Improvement of the axial trapping effect using azimuthally polarised trapping beam (2010)

A dual optical tweezers system, which consists of a doughnut mode optical tweezer (DMOT) with the azimuthally polarised trapping beam and a solid mode optical tweezer (SMOT) with the Gauss trapping beam was constructed to compare the axial trapping effect of DMOT and SMOT. The long-distance axial trapping of ST68 microbubbles (MBs) achieved by DMOT was more stable than that of SMOT. Moreover the axial trapping force measured using the viscous drag method, was depended on the diameter of the particle, the laser power, and the numerical aperture (NA) of the objective lens. The measurement of the axial trapping force and the acquisition of CCD images of trapping effect confirmed that the DMOT showed excellent axial trapping ability than SMOT. A simple and effective method is developed to improve axial trapping effect using the azimuthally polarized beam as trapping beam. This is helpful for the long-distance manipulating of particles especially polarised biological objects in axial direction.
Human-robots collaboration system for flexible object handling (2002)

A new concept of the human-robots collaboration is introduced in this system; the task is shared among the human and the robots. The robots appropriately deform and support the object, so that the human can easily handle it by only applying his/her intentional force to the object. First, the controller of multiple robots is designed so as to decrease the effect of noises from force sensors. Then deformation control of the flexible object is designed using the internal force applied to the object. The control system is experimentally implemented in a dual manipulator system which consists of two industrial robots. The experimental results illustrate the concept of the system.
Cyclooxygenase-2 and epidermal growth factor receptor inhibition in an orthotopic murine model of human lung adenocarcinoma (2004)

7362 Background: Activated epidermal growth factor receptors (EGFR) and cyclooxygenase-2 (COX-2) enzyme play a related role in growth, apoptosis, angiogenesis, and metastatic spread of lung cancer. Inhibition of these targets using orally available agents is a potential therapeutic strategy for non-small cell lung cancer (NSCLC). We aim to establish the effect of EGFR and COX-2 blockade on growth and metastatic spread in an orthotopic murine model of lung adenocarcinoma. Methods: Human lung adenocarcinoma cells expressing EGFR and COX-2 (ATCC-CRL5908) were implanted in the left upper lobe of SCID mice (2×106 cells/25uL). Mice were randomly assigned to one of 3 treatments at the time of implantation (n=10/group); normal chow, celecoxib (25mg/kg body weight/day), erlotinib (OSI-774) (15mg/kg body weight/day). At 3 weeks mice were killed and a blinded observer measured primary tumor volume and mediastinal metastatic disease. Primary and mediastinal tumor was confirmed histologically and EGFR and COX-2 expression was established by immunohistochemistry and PCR. Results: All 30 mice survived 3 weeks with no observed toxicities. Primary tumor inhibition occurred in both treatment groups. The mean primary tumor volume was 47mm3 ± 31 SD in the control group. The mean primary tumor volume was 6.8mm3 ± 9.1 SD, and 5.1mm3 ± 7.1 SD in the erlotinib and celecoxib treated groups respectively (p<0.0001; ANOVA). The median number of mediastinal nodal metastasis decreased from 17 lymph nodes (LN) in the control group to 10 LN in the erlotinib group and 8 LN in the celecoxib treated group. Conclusions: Targeted therapy inhibiting EGFR or COX-2 decreases primary tumor burden in an orthotopic model of lung adenocarcinoma. Combination therapy is being studied further. Given the details of each pathway and the potential for cross-talk, an increased benefit with combined treatment is expected. No significant financial relationships to disclose.
Sport Notes: Field & Clinical Examination Guide (2008)

Screening Pre-season screening Equipment Ambulation devices, Helmet fitting, Pads Emergency CPR, Trauma Integumentary Skin Conditions Ortho Musculoskeletal Pathology, Treatment Tests Pathology Wells Clinical Score for Deep Vein Thrombosis, Signs & Symptoms, Neuropsychiatric Disorders Modalities Edema, Heat & Cold, Ultrasound Electrical Stimulation, Pain Management, Iontophoresis, Traction, Intermittent Compression Taping & Wrapping A-C taping, Shoulder spica, Elbow hyperextension, Wrist support, Thumb spica, Boxer's wrap , Finger check reins, Hip spica, Knee hyperextension, Patella tracking, Achilles tendon, Ankle lateral support, open & closed basket weave, Ankle wrap, Low dye technique, Turf toe
Control over Molecular Architectures of Carbohydrate-Based Block Copolymers for Stretchable Electrical Memory Devices (2018)

We synthesized a series of new intrinsically stretchable block copolymers (BCPs) in linear AB-type, ABA-type, and star-shaped architectures composed of oligosaccharide (MH) and flexible poly(n-butyl acrylate) (PBA) blocks for the application in field-effect transistor memory. The BCP thin films are used as the charge trapping layers in the memory devices where the BCPs phase separate into ordered MH microdomains in soft PBA matrices. The MH microdomain works as the charge-trapping sites while the soft PBA matrix provides a stretchability. In particular, the BCPs of the ABA-type and star-shaped architectures with the end MH blocks not only show superior memory performances but also form physical networks that impart mechanical resilience to the thin films such that they can endure 100% strain without formation of cracks. The mobilities and the memory windows of the devices are nearly constant even when the charge trapping layers are stretched and released at 50% strain for 1000 cycles. This work highlights the importance of the molecular architectures on the BCPs intended for stretchable electronic materials.
P3‐348: Targeted high‐expression of ACE to myelomonocytic cells diminishes Alzheimer's‐like pathology and restores memory and learning in mouse models (2012)

Previous studies from our group and others have demonstrated that peripheral immune cells and especially infiltrating blood-borne monocytes can home to pathological beta-amyloid protein aggregates (Aβ plaques) and facilitate their clearance by phagocytosis and secretion of Aβ-degrading enzymes. One of the enzymes that was shown capable of degrading Aβ and convert the deleterious Aβ (1-42) to shorter nontoxic isoforms is angiotensin-converting enzyme (ACE). We found a marked reduction in Aβ plaque number and size in the cortex and hippocampus of 5, 7 and 12 month-old AD mice; above 40% decrease in mice having one ACE10 allele and above 80% in mice having two ACE10 alleles. Moreover, the levels of soluble neurotoxic Aβ (1-42) isoforms were substantially decreased in brain and plasma of ACE10xADtg mice. Importantly, ADtg mice carrying either one or two ACE10 alleles had a considerable improvement in learning and memory functions as assessed by a panel of behavioral tests such as the Barnes maze, and were indistinguishable than the wild type non-AD mice. These effects were accompanied by an extensive reduction in cortical astrogliosis as assessed by number and area of reactive GFAP-positive astrocytes. Flow cytometry analysis of immune cell profiles in the brain revealed a significant increase in migration of ACE10-overexpessing monocytes as compared to wt monocytes in ADtg mice. These studies indicate that selective ACE-overexpression in microglia and monocytes leads to a remarkable attenuation of AD-like progression in mouse models. Therefore, targeted overexpression of ACE on monocytes may present a highly promising and novel disease-modifying approach for AD treatment.
Characterization of New Spt3 and TATA-Binding Protein Mutants of Saccharomyces cerevisiae: Spt3–TBP Allele-Specific Interactions and Bypass of Spt8 (2007)

The Spt-Ada-Gcn5-acetyltransferase (SAGA) complex of Saccharomyces cerevisiae is a multifunctional coactivator complex that has been shown to regulate transcription by distinct mechanisms. Previous results have shown that the Spt3 and Spt8 components of SAGA regulate initiation of transcription of particular genes by controlling the level of TATA-binding protein (TBP/Spt15) associated with the TATA box. While biochemical evidence exists for direct Spt8-TBP interactions, similar evidence for Spt3-TBP interactions has been lacking. To learn more about Spt3-TBP interactions in vivo, we have isolated a new class of spt3 mutations that cause a dominant-negative phenotype when overexpressed. These mutations all cluster within a conserved region of Spt3. The isolation of extragenic suppressors of one of these spt3 mutations has identified two new spt15 mutations that show allele-specific interactions with spt3 mutations with respect to transcription and the recruitment of TBP to particular promoters. In addition, these new spt15 mutations partially bypass an spt8 null mutation. Finally, we have examined the level of SAGA-TBP physical interaction in these mutants. While most spt3, spt8, and spt15 mutations do not alter SAGA-TBP interactions, one spt3 mutation, spt3-401, causes a greatly increased level of SAGA-TBP physical association. These results, taken together, suggest that a direct Spt3-TBP interaction is required for normal TBP levels at Spt3-dependent promoters in vivo.
Supplementary Figure 5 from Inhibition of MAPK Kinase Signaling Pathways Suppressed Renal Cell Carcinoma Growth and Angiogenesis <i>In vivo</i> (2023)

Supplementary Figure 5 from Inhibition of MAPK Kinase Signaling Pathways Suppressed Renal Cell Carcinoma Growth and Angiogenesis &lt;i&gt;In vivo&lt;/i&gt;
High-speed 3D laser printing by two-photon induced chemistry: breaking the centimeter-scale limit (2015)

International audience
Lectin Ligands: New Insights into Their Conformations and Their Dynamic Behavior and the Discovery of Conformer Selection by Lectins (1998)

The mysteries of the functions of complex glycoconjugates have enthralled scientists over decades. Theoretical considerations have ascribed an enormous capacity to store information to oligosaccharides. In the interplay with lectins sugar-code words of complex carbohydrate structures can be deciphered. To capitalize on knowledge about this type of molecular recognition for rational marker/drug design, the intimate details of the recognition process must be delineated. To this aim the required approach is garnered from several fields, profiting from advances primarily in X-ray crystallography, nuclear magnetic resonance spectroscopy and computational calculations encompassing molecular mechanics, molecular dynamics and homology modeling. Collectively considered, the results force us to jettison the preconception of a rigid ligand structure. On the contrary, a carbohydrate ligand may move rather freely between two or even more low-energy positions, affording the basis for conformer selection by a lectin. By an exemplary illustration of the interdisciplinary approach including up-to-date refinements in carbohydrate modeling it is underscored why this combination is considered to show promise of fostering innovative strategies in rational marker/drug design.
Discrepancies between clinic and ambulatory blood pressure responses to cilazapril therapy. (1994)

Cilazapril in either dosage induced significant and similar antihypertensive effects on clinic blood pressure shortly after dosing (2 to 4 h), persisting during chronic treatment; however, no relevant effect persisted at the end of dosing (24 h). After four weeks, at the end of dosing, 22, 24 and 38% of patients were clinical responders (decrease in sitting diastolic blood pressure 10 mmHg or greater) on placebo, 2.5 or 5 mg (differences not significant). Conversely, both cilazapril regimens induced similar and significant (P < 0.01) falls in mean 24 h ABP compared with placebo. Moreover, 7, 50 and 48% of patients exhibited a reduction in mean 24 h diastolic blood pressure 10 mmHg or greater on placebo, cilazapril 2.5 or 5 mg, respectively. Furthermore, both regimens induced adequate trough:peak ratios on ABP.
Effects of triazolam on conditioned behavior in rats (1978)

ラットを用いて4種類の条件行動に対するtriazolamの作用をdiazopamのそれと比較した．（1）Shuttle box法におけるラットの条件回避反応はtriazolamおよびdiazepamの大量によって抑制され，その作用のED50はtriazolam 28.2（14.1～56.4），diazepam 46.0（30.1～70.4）mg/kg，p.o.であった．しかし両薬物とも回避反応を抑制する用量では逃避反応まで抑制されることが多く，neurolepticsの作用とは異なる．（2）Step-down法によるラットの受動的条件回避反応は，triazolamおよびdiazepamの40mg/kg，p.o.の大量投与でも影響を受けなかった．Chlorpromazineはこの回避反応を明らかに抑制した．（3）外側視床下部に慢性電極を植込んだラットの脳内自己刺激行動（self-stimulation behavior）のうち，低電流通電によるlow rate responseはtriazolam 2mg/kg，p.o.投与で著明に増加し，その作用は40mg/kg，p.o.の大量でも認められたが，80mg/kg以上の過大量では逆に抑制された．Diazepamも同様に2～10mg/kg，p.o.の用量でlow rate responseの著明な増加をおこし，80mg/kgでは逆にこれを抑制した．この作用はtriazolamのそれとほぼ同程度である．高電流通電によるhigh rate responseはtriazolamの160mg/kgの大量ではじめて抑制され，この作用もdiazepamとほぼ同程度であった．（4）Skinner boxにおけるミルク取りのレバー押し反応に床電撃を組合わせて設定したラットのconflict実験において，triazolamは1mg/kg，p.o.の投与で罰期における反応を増加させ，この作用は用量増加に伴って一層著明となった．Dlazepamは15mg/kg, p.o.以上の投与で安全期における反応を抑制し，罰期における反応の増加をおこした．以上ラットの条件行動に対するtriazolamの作用は，質的にはziazepamに類似するが，特に抗confict作用がdiazepamより約10倍強力である点が特徴である．
ChemInform Abstract: A Stereoselective Approach to the Synthesis of γ‐Silylated Amino Acids. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Linguistic and Cultural Adaptation to Spanish of the Screening Tool Psoriatic arthritis UnclutteRed Screening Evaluation (PURE4) (2020)

This adaptation of the PURE-4 questionnaire for use in Spain has been the first step toward using it in routine clinical practice. The standardized method we used ensures that the Spanish and the original versions are equivalent.
Drainage and Antireflux Characteristics of a Biodegradable Self-Reinforced, Self-Expanding X-Ray-Positive Poly-L,D -Lactide Spiral Partial Ureteral Stent: An Experimental Study (2007)

A self-expandable, self-reinforced SR-PLA 96 partial ureteral stent showed more favorable antireflux properties than a Double-J stent.