gebhart/patrepeval huggingface dataset:
Computing selected solutions of polynomial equations (1994)

We present efficient and accurate algorithms to compute solutions of zero-dimensional multivariate polynomial equations in a given domain. Earlier methods for solving polynomial equations are based on iterative methods, homotopy methods or symbolic elimination. The total number of solutions correspond to the Bezout bound for dense polynomial systems or the BKK bound for sparse systems. In most applications the actual number of solutions in the domain of interest is much lower than the Bezout or BKK bound. Our approach is based on global formulation of the problem using resultants and matrix computations and localizing it to find selected solutions only. The problem of finding roots is reduced to computing eigenvalues of a generalized companion matrix and we use the structure of the matrix to compute the solutions in the domain of interest only. The resulting algorithm is iterative in nature and we discuss its performance on a number of applications.
MPEG-5 Part 1: Essential Video Coding (2020)

<italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">The Motion Picture Experts Group (MPEG) standardization group has produced a large number of standards for video compression over the last three decades. Traditionally, the MPEG standards have either focused on highest available compression efficiency [e.g., MPEG-2, advanced video coding (AVC), and high-efficiency video coding (HEVC)] or a desire to produce a royalty-free standard [e.g., Internet video coding (IVC) and web video coding (WebVC)]. In January 2019, MPEG embarked on a new standardization project that can be seen as a hybrid of the two: MPEG-5 part 1 and essential video coding (EVC) [International Organization for Standardization/International Electrotechnical Commission (ISO/IEC) 23094-1]. The EVC standard was developed with a royalty-free baseline profile at its base and a royalty bearing main profile that provides excellent compression performance. The main profile adds, on top of the baseline profile, 21 different coding tools that each can be individually turned off and, when necessary, replaced by a corresponding baseline profile tool. This structure makes it easy to fall back to a smaller set of tools in the future, if, for example, licensing complications occur around a specific tool, without breaking compatibility with already deployed decoders</i> .
Energy Transfer in Vials Nested in a Rack System During Lyophilization (2020)

Small batch sizes are a consequence of more personalized medicine and reflect a trend in the biopharmaceutical industry. Freeze drying of vials nested in a rack system is a tool used in new flexible pilot scale processing lines. Understanding of heat transfer mechanisms in the rack loaded with vials not in direct contact with each other is necessary to ensure high quality. Lyophilization in the rack vial system enables a homogeneous drying with a reduced edge-vial-effect and shielding against radiation from surrounding components, e.g., the chamber wall. Due to the separation effect of the rack, direct shelf contact contributes approx. 40% to the overall energy transfer to the product during primary drying. Hence overall the rack is a flexible, robust tool for small batch production, which ensures a controlled heat transfer resulting in a uniform product.
Robust specification of sensory neurons by dual functions of charlatan, a Drosophila NRSF/REST-like repressor of extramacrochaetae and hairy (2011)

Sensory bristle formation in Drosophila is a well-characterized system for studying sensory organ development at the molecular level. The master proneural genes of the achaete-scute (ac-sc) complex, which encode basic-helix-loop-helix (bHLH) transcription factors, are necessary and sufficient for sensory bristle formation. charlatan (chn) was originally identified as a transcriptional activator of ac-sc gene expression through interaction with its enhancer, an activity that promotes sensory bristle development. In contrast, Chn was also identified as a functional homologue of mammalian neuron-restrictive silencing factor or RE1 silencing transcription factor (NRSF/REST), an important transcriptional repressor during vertebrate neurogenesis and stem cell development that acts through epigenetic gene silencing. Here, we report that Chn acts as a repressor of extramacrochaetae (emc) and hairy, molecules that inhibit ac-sc expression. This double-negative mechanism, together with direct activation via the achaete enhancer, increases expression of achaete and ensures robust development of sensory neurons. A mutation in the C-terminal repressor motif of Chn, which causes Chn to lose its repression activity, converted Chn to an activator of emc and hairy, suggesting that Chn is a dual functional regulator of transcription. Because chn-like sequences are found among arthropods, regulation of neuronal development by Chn-like molecules may be widely conserved.
Application of Photoalignment Materials in Optical Elements (2008)

This chapter contains sections titled: Polarizers Retardation Films Transflective LCD with Photo-patterned Polarizers and Phase Retarders Security Applications of Photoaligning and Photo-patterning Optical Elements Based on Photoaligning Technology References
Transport properties of graphene nanoribbon transistors on chemical-vapor-deposition grown wafer-scale graphene (2012)

Graphene nanoribbon (GNR) field-effect transistors (FETs) with widths down to 12 nm have been fabricated by electron beam lithography using a wafer-scale chemical vapor deposition (CVD) process to form the graphene. The GNR FETs show drain-current modulation of approximately 10 at 300 K, increasing to nearly 106 at 4 K. The strong temperature dependence of the minimum current indicates the opening of a bandgap for CVD-grown GNR-FETs. The extracted bandgap is estimated to be around 0.1 eV by differential conductance methods. This work highlights the development of CVD-grown large-area graphene and demonstrates the opening of a bandgap in nanoribbon transistors.
Influence of Filler and Base Material on the Pore Development during Reactive Air Brazing (2014)

Innovative technologies such as solid oxide fuel cells for energy generation make high demands on materials that can often be met by embedding ceramic components into metallic structures. A promising and economic method of joining ceramic to metal or to ceramic is reactive air brazing (RAB). A disadvantage of the RAB joints is the high porosity which can lessen the strength of the joint as well as its gas tightness. Different stages of pore development in dependence of filler and base materials could be observed during the brazing process due to the vaporising of the organic binder, the melting process and a reaction between the filler metal and the base material. By adjusting the process parameters the pore formation can be decreased.
EAGr: Supporting Continuous Ego-centric Aggregate Queries over Large Dynamic Graphs (2014)

In this work, we present EAGr, a system for supporting large numbers of continuous neighborhood-based ("ego-centric") aggregate queries over large, highly dynamic, and rapidly evolving graphs. Examples of such queries include computation of personalized, tailored trends in social networks, anomaly/event detection in financial transaction networks, local search and alerts in spatio-temporal networks, to name a few. Key challenges in supporting such continuous queries include high update rates typically seen in these situations, large numbers of queries that need to be executed simultaneously, and stringent low latency requirements. We propose a flexible, general, and extensible in-memory framework for executing different types of ego-centric aggregate queries over large dynamic graphs with low latencies. Our framework is built around the notion of an aggregation overlay graph, a pre-compiled data structure that encodes the computations to be performed when an update/query is received. The overlay graph enables sharing of partial aggregates across multiple ego-centric queries (corresponding to the nodes in the graph), and also allows partial pre-computation of the aggregates to minimize the query latencies. We present several highly scalable techniques for constructing an overlay graph given an aggregation function, and also design incremental algorithms for handling structural changes to the underlying graph. We also present an optimal, polynomial-time algorithm for making the pre-computation decisions given an overlay graph, and evaluate an approach to incrementally adapt those decisions as the workload changes. Although our approach is naturally parallelizable, we focus on a single-machine deployment and show that our techniques can easily handle graphs of size up to 320 million nodes and edges, and achieve update/query throughputs of over 500K/s using a single, powerful machine.
Design of a Wideband Dual-Polarization Full-Corporate Waveguide Feed Antenna Array (2015)

A wideband and dual-polarization antenna array with high efficiency and high isolation is proposed. In order to achieve the desired performance, a wideband radiating element and a full-corporate waveguide feed network are employed in the design. In particular, E-plane waveguides are utilized for the feed-network configuration so as to suppress wave leakage between adjacent layers when the antenna is fabricated via conventional machining techniques. The operational mechanism is presented and a 16 × 16 antenna array is tested for verification. Experimental results show that the bandwidths of VSWR <; 2.0 for both of the polarizations are about 17.1% (12.45-14.78 GHz) and the isolation between the two polarization ports is better than 39.5 dB. In addition, more than 70% antenna efficiency with higher than 29.4 dBi gain is achieved over the operational bandwidth.
Synergistic Interactions of TLR2/6 and TLR9 Induce a High Level of Resistance to Lung Infection in Mice (2011)

Infectious pneumonias exact an unacceptable mortality burden worldwide. Efforts to protect populations from pneumonia have focused historically on antibiotic development and vaccine-enhanced adaptive immunity. However, we have reported recently that the lungs' innate defenses can be induced therapeutically by inhalation of a bacterial lysate that protects mice against otherwise lethal pneumonia. In this study, we tested in mice the hypothesis that TLRs are required for this antimicrobial phenomenon and found that resistance could not be induced in the absence of the TLR signaling adaptor protein MyD88. We then attempted to recapitulate the protection afforded by the bacterial lysate by stimulating the lung epithelium with aerosolized synthetic TLR ligands. Although most single or combination treatments yielded no protection, simultaneous treatment with ligands for TLR2/6 and TLR9 conferred robust, synergistic protection against virulent gram-positive and gram-negative pathogens. Protection was associated with rapid pathogen killing in the lungs, and pathogen killing could be induced from lung epithelial cells in isolation. Taken together, these data demonstrate the requirement for TLRs in inducible resistance against pneumonia, reveal a remarkable, unanticipated synergistic interaction of TLR2/6 and TLR9, reinforce the emerging evidence supporting the antimicrobial capacity of the lung epithelium, and may provide the basis for a novel clinical therapeutic that can protect patients against pneumonia during periods of peak vulnerability.
Neighbor Discovery for IP Version 6 (IPv6) (1998)

This document specifies the Neighbor Discovery protocol for IP Version 6. IPv6 nodes on the same link use Neighbor Discovery to discover each other's presence, to determine each other's link-layer addresses, to find routers and to maintain reachability information about the paths to active neighbors.
Clinical Neurophysiology Using Electroencephalography in Geriatric Psychiatry: Neurobiologic Implications and Clinical Utility (1999)

Electroencephalography (EEG) offers a unique contribution to the armamentarium of imaging technologies used in the evaluation of brain function. The primary clinical application of EEG is in the diagnosis of delirium, dementia, and epilepsy, which are frequently encountered in the practice of geropsychiatry. This review summarizes the principles behind generation of the EEG signal, its strengths and limitations as a technology, clinical indications for performing an EEG, the principles underlying quantitative EEG (QEEG), and how QEEG is allowing us to probe brain function and connectivity in new ways.
Pulmonary Excretion of Carbon Monoxide in the Human Infant as an Index of Bilirubin Production IV. Effects of Breast-feeding and Caloric Intake in the First Postnatal Week (1980)

Measurements of the pulmonary excretion rate of carbon monoxide (VEco) as an index of bilirubin production in the first several days of life were taken from 64 breast-fed or bottle-fed infants. Twenty-one infants (greater than or equal to 37 weeks of gestation) were breast-fed; 43 infants (28 to 42 weeks of gestation) were bottle-fed a commercially prepared formula. Information pertaining to their caloric intake during the 24-hour period preceding VEco determination was taken from 38 of the 43 infants who were bottle-fed and they were placed into three groups based on their caloric intake: (1) less than or equal to 60 kcal/kg/day (19 infants); (2) 61 to 100 kcal/kg/day (7 infants); and (3) greater than 100 kcal/kg/day (12 infants). There was no significant difference in bilirubin production between bottle-fed and breast-fed infants. No effect of caloric deprivation on bilirubin production was demonstrated. The mean VEco values were 18.5 +/- 0.9 (SE) for group 1, 17.7 +/- 1.8 (SE) for group 2, and 16.2 +/- 1.1 (SE) microliter/kg/hr for group 3.
P3‐074: Detection of Alzheimer's disease‐linked changes in the lens by quasi‐elastic light scattering ophthalmoscopy in young subjects with down syndrome (2015)

Alzheimer's disease (AD) is characterized by age-related amyloid β peptides (Aβ) deposition in the brain. We discovered that Aβ also accumulates in the supranuclear subregion of the ocular lens in people with AD (Goldstein, Lancet, 2003). We subsequently reported identical AD-linked Aβ lens pathology in Down syndrome (DS; (Moncaster, PloS One, 2010), a common chromosomal disorder that is invariantly associated with early-onset AD neuropathology. In AD and DS lenses, Aβ accumulates as electron-dense intracellular aggregates that accumulate in the cytoplasm of supranuclear lens fiber cells. These Aβ lens aggregates interact with light as Raleigh scattering centers that ultimately manifest as distinctive AD-specific supranuclear lens opacities. We conducted a clinical study at Boston Children's Hospital (BCH) in young DS subjects compared to age-matched normal controls (CON). We used an investigational quasi-elastic light scattering (QLS) scanning laser ophthalmoscope to noninvasively assess protein scattering properties in the lens. QLS analyzes time-dependent light scattering intensity fluctuations from which autocorrelation functions can be derived. Study cohorts: 8 DS subjects (DS, 3 females, 5 males; mean age: 13.6 ± 2.1 years), 15 normal controls (CON, 6 females, 9 males; mean age: 15.5 ± 1.9 years). The study was approved by the BCH Institutional Review Board. All subjects were evaluated by routine ophthalmic examination followed by QLS ophthalmoscopic assessment for AD-linked lens pathology in the supranucleus. We hypothesized that increased expression of Aβ in DS lenses would increase QLS-detectable changes in the lenses of DS but not CON subjects. Our results reveal a statistically significant difference (p =0.04) in the average scattering intensity and a highly significant difference (p = 6.5x10-5) in average decay time (tau function) between the two groups. These results indicate that QLS ophthalmoscopy can be used clinically to noninvasively detect and discriminate AD-linked protein differences in the lenses of DS subjects compared to age-matched normal controls. These findings are consistent with our previous findings of early AD-linked Aβ lens pathology in DS and extend these results to living subjects evaluated by noninvasive QLS ophthalmoscopy.
MP64-07 DIABETES MELLITUS AS AN INDEPENDENT PREDICTOR OF SURVIVAL OF PATIENTS SURGICALLY TREATED FOR RENAL CELL CARCINOMA: A PROPENSITY SCORE MATCHING STUDY. (2016)

METHODS: Patients diagnosed with UTUC were identified in the SEER database from 2004-2011 (n8, 805). Descriptive statistics were used to compare demographic and clinicopathologic variables between patients with non-metastatic renal pelvis and ureteral UTUC. Overall survival (OS) and disease-specific survival (DSS) were compared for patients with non-metastatic disease at diagnosis using log-rank test and Kaplan Meier analysis. Multivariable logistic regression models with backward selection were performed to generate odds ratios (OR) for factors associated with metastasis at diagnosis. RESULTS: There were 5,444 (61.8%) patients with renal pelvis and 3,361 (38.2%) with ureteral UTUC. Among these patients, there were 4,745 (87.2%) with renal pelvis and 3,124 (92.9%) with ureteral UTUC that had non-metastatic disease at diagnosis. Patients with nonmetastatic ureteral UTUC at diagnosis were more likely to be older (median 75 (IQR 14) vs 74 (IQR 16) years, p0.001), male (61.3 vs 58.6%, p0.02), and non-black or white race (7.7 vs 6.2%, p0.03) compared to those with renal pelvis UTUC. Patients with ureteral UTUC were more likely to have AJCC Stage I disease and less likely to have Stage III disease (Stage I -36.1 vs 33.1%; Stage III e 23.0 vs 32.4%, p<0.001). There was no difference in OS (p0.72), however patients with renal pelvis UTUC had worse DSS (p0.01). Factors associated with distant metastasis at diagnosis for renal pelvis UTUC included black race (OR 1.74, 95%CI 1.14-2.65; p0.01) and high-grade disease (OR 1.42, 95%CI 1.25-1.62; p<0.001). High-grade disease (OR 1.29, 95%CI 1.07-1.57; p0.009) was the only factor associated with distant metastasis at diagnosis for patients with ureteral UTUC.
ER-Quality Control is required for Cf-protein function (2011)

PO-22 ER-Quality Control is required for Cf-protein function Thomas Liebrand1, Jan Cordewener2, Antoine America2, and Matthieu Joosten1 1 Laboratory of Phytopathology, Wageningen University, The Netherlands 2 Plant Research International, Business Unit Bioscience, Wageningen University and Research Centre, The Netherlands The plasma membrane-resident tomato (Solanum lycopersicum) Cf receptor-like proteins recognize Avr effectors of the fungal pathogen Cladosporium fulvum. To date, few host components involved in Cf-biogenesis and signaling have been identified. We perform affinity purification from plant extracts to identify Cf-interacting proteins. We transiently expressed a Cf-4-eGFP fusion protein in Nicotiana benthamiana by agroinfiltration. Immunoprecipitation of Cf-4-eGFP and subsequent mass spectrometry analysis revealed the endoplasmic reticulum (ER)-resident HSP70 chaperone Binding Protein 1 BiP1 as co-purifying protein. Co-Immunoprecipitation assays revealed that BiP also interacts with transiently expressed eGFP tagged Cf-2, Cf-9, Cf-4E and Peru2 (a Cf homolog). BiP is part of an ER-chaperone complex together with ERdj3b and SDF2. Besides the BiP chaperone complex, the N-linked glycosylation pathway including the ER-localized lectin-like chaperone calreticulins (CRTs) are involved in ER-quality control (ER-QC). Using Virus-Induced Gene Silencing in transgenic N. benthamiana:Cf-4 plants we studied the role of ER-QC for Cf-4 functioning. We discovered that silencing of specifically CRT3-likes reduced the Avr4-triggred HR, but not the HR triggered by the CC-NB-LRR autoactive mutant Rx(D460V) or the apoptotic factor BAX. Silencing of NbBiP1 did not reduce Avr4-triggered HR, which may be explained by redundancy with one of the other two BiPs. Acknowledgements This work is supported by CBSG2012 PG6 and CBSG Hotel project TD8-08.
Cabozantinib for metastatic breast carcinoma: results of a phase II placebo-controlled randomized discontinuation study (2016)

In heavily pretreated MBC patients, cabozantinib monotherapy demonstrated clinical activity including objective response and disease control.
Противовоспалительные и иммуномодулирующие свойства сесквитерпенового лактона арглабин при экспериментальном хроническом эндометрите (2005)

Arglabin at the dose of 10 mg/kg was shown to inhibit the inflammatory processes and to enhance the regeneration processes in the uterine endometrium. Therapeutic effect of Arglabin at 10 mg/kg dose is comparable with that of thymaline. The stated concentration of Arglabin stimulates T-lymphocyte outflow from the T-dependant periarteriai probe and phagocytosis processes in the spleen. Arglabin affects central chain of immunogenesis through the reduction of thymocyte amount in the cortical and medullar substances of thymus lobules.
Trust (2015)

Abstract Trust is viewed as an important influence affecting the effectiveness of interorganizational relationships because, in order to make commitments through investment in joint projects, sharing information, or engaging in other forms of partnership, organizations need to be assured that partners will not engage in opportunistic behavior.
Improving the performance of photovoltaic cells based on nanocomposites with contorted polycyclic aromatic hydrocarbon additive in bulk heterojunction (2021)

Cocrystal formation due to a combination between 4Cl-cHBC and bulk heterojunction for improving the efficiency. The power conversion efficiency of a device using the 4Cl-cHBC additives is 9.46%, which is 20.6% higher than that of a reference device.
The Human Lagging Strand DNA Polymerase δ Holoenzyme Is Distributive (2012)

Polymerase δ is widely accepted as the lagging strand replicative DNA polymerase in eukaryotic cells. It forms a replication complex in the presence of replication factor C and proliferating cell nuclear antigen to perform efficient DNA synthesis in vivo. In this study, the human lagging strand holoenzyme was reconstituted in vitro. The rate of DNA synthesis of this holoenzyme, measured with a singly primed ssM13 DNA substrate, is 4.0 ± 0.4 nucleotides. Results from adenosine 5'-(3-thiotriphosphate) tetralithium salt (ATPγS) inhibition experiments revealed the nonprocessive characteristic of the human DNA polymerase (Pol δ) holoenzyme (150 bp for one binding event), consistent with data from chase experiments with catalytically inactive mutant Pol δ(AA). The ATPase activity of replication factor C was characterized and found to be stimulated ∼10-fold in the presence of both proliferating cell nuclear antigen and DNA, but the activity was not shut down by Pol δ in accord with rapid association/dissociation of the holoenzyme to/from DNA. It is noted that high concentrations of ATP inhibit the holoenzyme DNA synthesis activity, most likely due to its inhibition of the clamp loading process.