gebhart/patrepeval huggingface dataset:
The Formin Family Protein, Formin Homolog Overexpressed in Spleen, Interacts with the Insulin-Responsive Aminopeptidase and Profilin IIa (2003)

Insulin stimulates translocation of glucose transporter isoform type 4 (GLUT4) and the insulin-responsive aminopeptidase (IRAP) from an intracellular storage pool to the plasma membrane in muscle and fat cells. A role for the cytoskeleton in insulin action has been postulated, and the insulin signaling pathway has been well investigated; however, the molecular mechanism by which GLUT4/IRAP-containing vesicles move from an interior location to the cell surface in response to insulin is incompletely understood. Here, we have screened for IRAP-binding proteins using a yeast two-hybrid system and have found that the C-terminal domain of FHOS (formin homolog overexpressed in spleen) interacts with the N-terminal cytoplasmic domain of IRAP. FHOS is a member of the Formin/Diaphanous family of proteins that is expressed most abundantly in skeletal muscle. In addition, there are two novel types of FHOS transcripts generated by alternative mRNA splicing. FHOS78 has a 78-bp insertion and it is expressed mainly in skeletal muscle where it may be the most abundant isoform in humans. The ubiquitously expressed FHOS24 has a 24-bp insertion encoding an in-frame stop codon that results in a truncated polypeptide. It is known that some formin family proteins interact with the actin-binding profilin proteins. Both FHOS and FHOS78 bound to profilin IIa via their formin homology 1 domains, but neither bound profilin I or IIb. Overexpression of FHOS and FHOS78 resulted in enhanced insulin-stimulated glucose uptake in L6 cells to similar levels. However, overexpression of FHOS24, lacking the IRAP-binding domain, did not affect insulin-stimulated glucose uptake. These findings suggest that FHOS mediates an interaction between GLUT4/IRAP-containing vesicles and the cytoskeleton and may participate in exocytosis and/or retention of this membrane compartment.
Overcoming the effects of correlation in packet delay measurements using inter-packet gaps (2005)

The end-to-end delay of packets in data streams is characterized with emphasis on effects due to cross traffic, sending rate and packet size. Measurements indicate that modeling delay of a packet stream with high sending rates, as a fraction of bandwidth, is difficult due to the correlations among the delay values. The correlations among inter-packet gaps (IPG) at these rates, however, are negligible. At lower sending rates, the delay correlations are negligible and the distribution of delay can be used as a delay model. We exploit the relation between delay and IPG to show that end-to-end delay can be approximated by a Markov process. Thus, a complete solution is presented for modeling delay for all sending rates. Further, a correlation estimation model is provided for delay and IPG values.
A new procedure for the optimization of a dielectric elastomer actuator (2008)

A novel mathematical procedure is proposed, which makes it possible to optimize lozenge-shaped dielectric-elastomer-based linear actuators for known materials and desired force/stroke requirements. Simulation results are provided which both demonstrate the efficacy of the novel procedure with respect to traditional design approaches and show that simpler, cheaper, lighter and better-behaved lozenge-shaped actuators can be conceived which do not require any integration of compliant frame elements.
Compartmentation of Fyn Kinase with Glycosylphosphatidylinositol-anchored Molecules in Oligodendrocytes Facilitates Kinase Activation during Myelination (1999)

In many cell types, glycosylphosphatidylinositol (GPI)-anchored proteins are sequestered in detergent-resistant membrane rafts. These are plasma membrane microdomains enriched in glycosphingolipids and cholesterol and are suggested to be platforms for cell signaling. Concomitant with the synthesis of myelin glycosphingolipids, maturing oligodendrocytes progressively associate GPI-anchored proteins, including the adhesion molecules NCAM 120 and F3, in rafts. Here we show that these microdomains include Fyn and Lyn kinases. Both kinases are maximally active in myelin prepared from young animals, correlating with early stages of myelination. In the rafts, Fyn kinase is tightly associated with NCAM 120 and F3. In contrast, in oligodendrocyte progenitor cells lacking rafts or in raft-free membrane domains of more mature cells, F3 does not associate with Fyn. The addition of anti-F3 antibodies to oligodendrocytes results in stimulation of Fyn kinase specifically in rafts. Compartmentation of oligodendrocyte GPI-anchored proteins in rafts is thus a prerequisite for association with Fyn, permitting kinase activation. Interaction of oligodendrocyte F3 with axonal ligands such as L1 and ensuing kinase activation may play a crucial role in initiating myelination.
A novel distributed strain sensor based on dynamic grating in polarization-maintaining erbium-doped fiber (2006)

We report the experimental demonstration of a novel distributed fiber-optic strain sensor by localizing a dynamic grating in polarization maintaining erbium-doped fiber (PM-EDF) using the technique of synthesis of optical coherence function (SOCF).
Renewable catalyst with Cu nanoparticles embedded into cellulose nano-fiber film (2013)

TEMPO-oxidized cellulose nano-fibril film embedded Cu nanoparticles had an excellent catalytic efficiency for nitroaromatic hydrogenation. Thus, this Cu-loaded film is an eco-friendly catalyst with a high performance, and this novel technique is expected to comprise a promising approach toward green and sustainable development.
Hyperspectral image denoising with segmentation-based low rank representation (2016)

Recently, low-rank representation (LRR) based hyperspectral image (HSI) denoising method has been proven to be a powerful tool for removing different kinds of noise simultaneously, such as Gaussian, dead pixels and impulse noise. However, the LRR based method cannot make full use of the spatial information in HSI. In this paper, we integrate the graph based segmentation (GS) into the LRR, and propose a novel denoising method named GS-LRR. We first use the principle component analysis (PCA) to obtain the first principle component of HSI. Then the graph based segmentation is adopted to the first principle component of HSI to get homogeneous regions. Finally, we employ the LRR to each homogeneous region of HSI, which enable us to simultaneously remove all the above mentioned mixed noise. Extensive experiments on both simulated and real HSIs demonstrate the efficiency of the proposed GS-LRR.
Multiwafer gas source molecular beam epitaxial system for production technology (1999)

High throughput epitaxial wafer production is demonstrated by using a newly designed multiwafer gas source molecular beam epitaxy apparatus. The actual application data show excellent results of uniformity, cost performance, and material performance through practical mass production operation. Electron mobility as high as 124 000 cm2/V s is obtained at 77 K for a 7-μm-thick GaAs layer with a carrier concentration of 7.7×1013 cm−3. A typical surface defect density of 25 cm−2 is achieved for continuously grown 1.7-μm-thick metal–semiconductor field effect transistor (MESFET) structures. The uniformity of sheet resistance in n-GaAs and AlAs mole fractions in AlGaAs is less than 2.0% (1.5% and 0.27%, respectively) over a 27 cm diameter area. A quantitative throughput number for a typical growth of a MESFET structure is four 4 in. or seven 3 in. diameter wafers per 2.5 h in a continuous process flow.
Regulation of beta-adrenergic receptor-mediated processes in fetal rat lung: selective desensitization caused by chronic terbutaline exposure. (1990)

Fetal lung beta-receptors become effectively coupled to lung fluid reabsorption and enzymes involved in surfactant synthesis on the day before birth, a period when circulating catecholamine levels are high. Accordingly, we examined the effects of repeated maternal terbutaline exposure on beta-receptor binding capabilities and beta-receptor-mediated processes in the fetal rat lung. Administration of terbutaline to pregnant rats on gestational day 17-20 produced significant reductions in beta-receptor binding to membrane preparations. Similarly, beta-receptor-mediated stimulation of adenylate cyclase activity and ornithine decarboxylase activity showed marked desensitization in the terbutaline-exposed fetuses. However, the linkage of beta-receptors to lung fluid reabsorption and phosphatidic acid phosphatase, an enzyme involved in surfactant synthesis, did not desensitize with chronic terbutaline pretreatment; both of these processes displayed the normal onset of responsiveness on gestational day 21 in the treated animals, as well as a normal magnitude of response. Hence, beta-receptor-mediated events in the developing lung may be differentially regulated during exposure to agonists, allowing the selective expression or depression of function when circulating catecholamine levels are high.
Action of long-chain fatty acids in vitro on Ca2+-stimulatable, Mg2+-dependent ATPase activity in human red cell membranes (1987)

Human red cell membrane Ca2+-stimulatable, Mg2+-dependent adenosine triphosphatase (Ca2+-ATPase) activity and its response to thyroid hormone have been studied following exposure of membranes in vitro to specific long-chain fatty acids. Basal enzyme activity (no added thyroid hormone) was significantly decreased by additions of 10(-9)-10(-4) M-stearic (18:0) and oleic (18:1 cis-9) acids. Methyl oleate and elaidic (18:1 trans-9), palmitic (16:0) and lauric (12:0) acids at 10(-6) and 10(-4) M were not inhibitory, nor were arachidonic (20:4) and linolenic (18:3) acids. Myristic acid (14:0) was inhibitory only at 10(-4) M. Thus, chain length of 18 carbon atoms and anionic charge were the principal determinants of inhibitory activity. Introduction of a cis-9 double bond (oleic acid) did not alter the inhibitory activity of the 18-carbon moiety (stearic acid), but the trans-9 elaidic acid did not cause enzyme inhibition. While the predominant effect of fatty acids on erythrocyte Ca2+-ATPase in situ is inhibition of basal activity, elaidic, linoleic (18:2) and palmitoleic (16:1) acids at 10(-6) and 10(-4) M stimulated the enzyme. Methyl elaidate was not stimulatory. These structure-activity relationships differ from those described for fatty acids and purified red cell Ca2+-ATPase reconstituted in liposomes. Thyroid hormone stimulation of Ca2+-ATPase was significantly decreased by stearic and oleic acids (10(-9)-10(-4) M), but also by elaidic, linoleic, palmitoleic and myristic acids. Arachidonic, palmitic and lauric acids were ineffective, as were the methyl esters of oleic and elaidic acids. Thus, inhibition of the iodothyronine effect on Ca2+-ATPase by fatty acids has similar, but not identical, structure-activity relationships to those for basal enzyme activity. To examine mechanisms for these fatty acid effects, we studied the action of oleic and stearic acids on responsiveness of the enzyme to purified calmodulin, the Ca2+-binding activator protein for Ca2+-ATPase. Oleic and stearic acids (10(-9)-10(-4) M) progressively inhibited, but did not abolish, enzyme stimulation by calmodulin (10(-9) M). Double-reciprocal analysis of the effect of oleic acid on calmodulin stimulation indicated noncompetitive inhibition. Addition of calmodulin to membranes in the presence of equimolar oleic acid restored basal enzyme activity. Oleic acid also reduced 125I-calmodulin binding to membranes, but had no effect on the binding of [125I]T4 by ghosts. The mechanism of the decrease by long chain fatty acids of Ca2+-ATPase activity in situ in human red cell ghosts thus is calmodulin-dependent and involves reduction in membrane binding of calmodulin.
Surface Modification of Reverse Osmosis Desalination Membranes with Zwitterionic Silane Compounds for Enhanced Organic Fouling Resistance (2021)

Three different zwitterionic functional trimethoxysilane compounds, 4-(diethyl(3-(trimethoxysilyl)propyl)ammonia)butane-1-sulfonate (EPBS), 4-(dimethyl(3-(trimethoxysilyl)propyl)ammonia)butane-1-sulfonate (MPBS), and 3-(dimethyl(3-(trimethoxysilyl)propyl)ammonia)propane-1-sulfonate (MPPS), were synthesized and used for the surface modification of commercial polyamide thin-film composite reverse osmosis membranes to enhance their salt rejection and antifouling performance. Commercial membrane surfaces were spray-coated using three different aqueous solution concentrations (1.0, 1.5, and 2.0%) of each zwitterionic silane compound. Surface characterization of coated membranes performed via X-ray photoelectron spectroscopy and water contact angle measurements confirmed the successful, permanent attachment of zwitterionic groups to membrane surfaces. Organic fouling studies accomplished through dead-end stirred cell filtration experiments using xanthan gum and bovine serum albumin revealed that all coated membranes had higher flux recovery rates upon cleaning with water and NaOH, demonstrating the easier cleanability provided by zwitterionic groups on the membrane surface. For example, in the case of xanthan gum fouling experiments, membranes coated with 2.0 wt % MPPS solution regained 100% of its initial flux after cleaning with deionized water, whereas the control membrane had 69% flux recovery.
Redox Heterogeneity in Mid-Ocean Ridge Basalts as a Function of Mantle Source (2013)

The oxidation state of Earth's upper mantle both influences and records mantle evolution, but systematic fine-scale variations in upper mantle oxidation state have not previously been recognized in mantle-derived lavas from mid-ocean ridges. Through a global survey of mid-ocean ridge basalt glasses, we show that mantle oxidation state varies systematically as a function of mantle source composition. Negative correlations between Fe(3+)/ΣFe ratios and indices of mantle enrichment--such as (87)Sr/(86)Sr, (208)Pb/(204)Pb, Ba/La, and Nb/Zr ratios--reveal that enriched mantle is more reduced than depleted mantle. Because carbon may act to simultaneously reduce iron and generate melts that share geochemical traits with our reduced samples, we propose that carbon creates magmas at ridges that are reduced and enriched.
Tailor's bunion: clinical evaluation and correction by distal metaphyseal osteotomy with cortical screw fixation. (1990)

Fifth metatarsal distal metaphyseal osteotomy represents a very common surgical procedure performed for tailor's bunion deformity. The authors advocate using a cortical bone screw for fixation device offers many advantages over conventional devices (i.e., Kirschner wire). The purpose of this paper is to offer a means to thoroughly evaluate tailor's bunion deformity clinically, biomechanically, and radiographically. This will allow the podiatric surgeon to choose a procedure of choice to correct the deformity. The technique of fifth metatarsal distal metaphyseal osteotomy with cortical bone screw fixation using AO4 principles is fully described.
A Study on biosurfactant production in Lactobacillus and Bacillus sp (2014)

Biosurfactants are amphiphilic biological compounds produced extracellularly or as part of the cell membranes by a variety of yeast, bacteria and filamentous fungi (Anandaraj and Thivakaran, 2010; Ghayyomi Jazeh et al., 2012) from various substances including sugars, oils and wastes (Jaysre et al., 2011; Kigsley and Pekdemir, 2004). However, carbohydrates and vegetable oils are among the most widely used substrates for research on biosurfactant production by Bacillus subtilis strains. The amphiphiles that form micelles can be potentially used for surface chemical works are termed as surface active agents or surfactants. Soaps and detergents can be described as having similar characteristics as surfactants. The investigation has been made for its emulsification capacity as biopreservative in food. Production and extraction of biosurfactant was carried out using Bacillus, Lactobacilli, the parameter optimization for the better growth of the strain was carried out. The extraction and emulsification potency of the surfactant was performed in order to use as bioemulsifier in food (Priya and Usharani, 2009).
Features of the photoconductivity and information characteristics of recording media based on films of poly-N-epoxypropyl carbazole doped with polymethine dyes of various ionicities (2002)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text A. D. Al'-Kadimi, N. A. Davidenko, V. A. Pavlov, N. G. Chuprina, N. A. Derevyanko, A. A. Ishchenko, and V. A. Pivtorak, "Features of the photoconductivity and information characteristics of recording media based on films of poly-N-epoxypropyl carbazole doped with polymethine dyes of various ionicities," J. Opt. Technol. 69, 744- (2002) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Progress in the surveillance and control of Legionella infection in France, 1998–2008 (2010)

All these measures have contributed to strengthen the French surveillance system and improve our ability to better prevent, detect, and control LD.
Identification of the histone lysine demethylase KDM4A/JMJD2A as a novel epigenetic target in M1 macrophage polarization induced by oxidized LDL (2017)

Oxidized low density lipoprotein (oxLDL) induces macrophage activation, an event essential for atherosclerosis. Emerging evidence supports that epigenetic regulation plays important roles in macrophage activation and function. However, it remains unclear which epigenetic modulator is responsible for oxLDL-induced macrophage activation. Here, we identify for the first time KDM4A (JMJD2A) as an epigenetic modifying enzyme that controls oxLDL-induced pro-inflammatory M1 polarization of macrophages. OxLDL triggered M1 polarization of murine and human macrophages, characterized by expression of iNOS and robust production of inflammatory cytokines (e.g., TNF-α, MCP-1, IL-1β). In contrast, protein level of the M2 marker Arg1 was clearly decreased after treated with oxLDL. Notably, exposure to oxLDL resulted in markedly increased expression of KDM4A in macrophages. Functionally, shRNA knockdown of KDM4A significantly impaired M1 polarization and expression of inflammatory cytokines induced by oxLDL, accompanied by increased expression of Arg1 and VEGF. However, inhibition of KDM4A by shRNA or the pan-selective KDM inhibitor JIB-04 did not affect oxLDL-mediated activation of the NF-κB and hypoxia inducible factor (HIF) pathways, and vice versa. In addition, JIB-04 induced apoptosis of macrophages in a dose-dependent manner, an event attenuated by oxLDL. Together, these findings argue that KDM4A might represent a novel epigenetic modulator that acts to direct oxLDL-induced M1 polarization of macrophages, while its up-regulation is independent of NF-κB and HIF activation, two signals critical for pro-inflammatory activation of macrophages. They also suggest that KDM4A might serve as a potential target for epigenetic therapy in prevention and treatment of inflammatory diseases such as atherosclerosis.
Analysis of the Convergence Process by EXIT Charts for Parallel Implementations of Turbo Decoders (2013)

Iterative process is a general principle in decoding powerful FEC codes such as turbo codes. However, the mutual information exchange during the iterative process is not easy to analyze and to describe. A useful technique to help the designer is the EXtrinsic Information Transfer (EXIT) chart. Unfortunately, this method cannot be directly applied to the decoding convergence analysis if parallel processing has to be exploited for the design of turbo decoders. In this letter, an extension of the EXIT charts method is proposed in order to take into account the constraints introduced by parallel implementations. The corresponding analysis associated with Monte-Carlo simulations gives additional understanding of the convergence process for the design of parallel architectures dedicated to turbo decoding.
Use of Dielectric Spectroscopy To Monitor Molecular Mobility in Glassy and Supercooled Trehalose (2012)

Dielectric spectroscopy was used to comprehensively characterize the molecular mobility in amorphous trehalose, an extensively used bioprotective agent. Isothermal frequency sweeps were carried out at different temperatures in the glassy and supercooled liquid states of freeze-dried trehalose. Two previously reported secondary relaxations were observed at temperatures far below its glass transition temperature (T(g)). At temperatures close to T(g), removal of dc conductivity contribution revealed a relaxation peak. The origin of this peak was evaluated using several diagnostic tests and determined to be the α-relaxation. There was also an excess wing in the high-frequency tail of α-relaxation. Sub-T(g) annealing caused the primary relaxation to shift to lower frequencies, enabling resolution of the excess wing, which was characterized to be the true Johari-Goldstein (JG) relaxation. A qualitatively similar effect of annealing on JG relaxation was also observed. The average relaxation times of the two previously reported secondary relaxations were unaffected by annealing.
Asbestos and silica exposures reveal similar and divergent gene expression patterns and pathways related to fibrosis in human bronchial epithelial cells (2012)

Background Asbestosis and silicosis, two common forms of pneumoconioses are caused by excessive exposure to airborne minerals, leading to pulmonary fibrosis. However, both diseases have distinct pathological presentations, which are likely due to the physicochemical characteristics of the two minerals. The epithelium is an initial target cell to come in contact with inhaled materials. The early molecular events that therefore take place in epithelial cells have a strong influence on the molecular and cellular responses that promote inflammation, lesion formation, and fibrosis. Methods Primary human bronchial epithelial cells were exposed to non-lethal doses of crocidolite asbestos and cristobalite silica for 24 hours. Affymetrix/GeneSifter® analysis utilizing pairwise-comparison, hierarchical cluster analysis, and Ingenuity pathway analysis® was used to reveal similar and unique gene expression patterns. Results Both minerals altered a number of genes related to inflammation, cell proliferation, apoptosis, cell-surface receptors, and transcription factors. Genes selectively altered by asbestos were related to evasion of apoptosis, MAPK signaling, and iron metabolism. Conversely, genes altered by silica were involved in TNF-signaling, TLR-signaling, and mitochondrial biogenesis. Similar and distinct pathways associated with inflammation and fibrosis were affected by both mineral exposures. Conclusions These studies exhibit initial changes in gene expression by asbestos and silica in target bronchial epithelial cells as early molecular events that may initiate the inflammatory and fibrotic responses leading to asbestosis and silicosis.
Analysis of Two-Photon Absorption in Tapered Fibers (2009)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text H. You, S. M. Hendrickson, and J. D. Franson, "Analysis of Two-Photon Absorption in Tapered Fibers," in Conference on Lasers and Electro-Optics/International Quantum Electronics Conference, OSA Technical Digest (CD) (Optica Publishing Group, 2009), paper IThM4. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article