gebhart/patrepeval huggingface dataset:
Acute Respiratory Distress Syndrome (2005)

Though well described even in ancient writings, the acute respiratory distress syndrome (ARDS) gained major medical attention with the availability of mechanical ventilation and establishment of intensive care units. In the 50 years since this beginning there have been remarkable advances in the understanding of the etiology, physiology, histology, and epidemiology of this often lethal complication of common human maladies. Until recently, improvements in outcome have mainly followed improvements in intensive care unit operation and their associated life support systems, and have not come through discoveries made in the course of prospective randomized trials. In spite of the remarkable increase in research focused on ARDS, there remain a large number of unanswered clinical questions that are potentially extremely important with regard to short-term morbidity as well as long-term outcome. The ARDS Clinical Trials Network study of tidal volume has proven that randomized trials in ARDS with positive results are possible even when using difficult primary outcome measures such as mortality or ventilator-free days. Therefore, the rich combination of new trial strategies, potential treatments, experienced investigators, and increasingly standardized routine care set the stage for rapid advances to be made in the short- and long-term outcomes of this devastating syndrome.
Consideration of PCR methods for the detection of SV40 in tissue and DNA specimens. (1998)

SV40 is capable of infecting humans, although its association with human diseases remains controversial. Recently, a subgenomic SV40 DNA sequence was detected by polymerase chain reaction (PCR) in certain types of human tumour tissue as well as in normal pituitary tissue. However, due to the limited DNA sequence information that was obtained in those experiments, SV40 could not be authenticated, and it was uncertain whether a related or hybrid virus (or endogenous DNA) accounted for the PCR-amplified DNA. To gain more insight into these observations, we are experimenting with PCR primers directed at various sites of the SV40 genome, as well as with various parameters of the PCR assay. In this communication, we describe methodology we currently use in our studies and discuss problems associated with the PCR detection of SV40 in various types of samples.
Laser Vapor Phase Synthesis of Submicron Silicon and Silicon Nitride Powders from Halogenated Silanes (2008)

Laser-vapor-phase synthesis of Si/sub 3/N/sub 4/ spherical amorphous powders, with particle sizes of submicron dimensions, from SiH/sub 2/Cl/sub 2/-NH/sub 3/ and SiCl/sub 4/-NH/sub 3/ mixtures, was achieved using a 150-W CW CO/sub 2/ and a specially developed laser reactor. A concentric N/sub 2/ gas stream was used to guide the ceramic powders into a high-temperature electrostatic precipitator in which Si/sub 3/N/sub 4/ was separated from the waste product NH/sub 4/Cl. The powders were characterized using IR spectroscopy, X-ray fluorescence, EDX, XRD, and electron diffraction, and particle sizes were estimated using TEM and BET analyses. 15 references.
Virotherapeutic treatment of cholangiocarcinoma using a novel armed oncolytic measles vaccine virus (2013)

Cholangiocarcinoma is curable only in early stages by complete surgical resection. Thus, in advanced disease stages in which a complete removal of the tumor mass is no longer possible and palliative chemotherapy only achieves modest success, therapeutics employing new methods of action are desperately needed. Oncolytic viruses employed in clinical studies have been shown to spread preferentially in cancer cells. Beyond that, virotherapeutic cell killing can be enhanced by virus-based expression of suicide genes. We engineered a measles vaccine virus (MeV) vector expressing SCD, a fusion protein of yeast cytosine deaminase and uracil phosphoribosyltransferase, which converts the prodrug 5-fluorocytosine (5-FC) to the chemotherapeutic compound 5-fluorouracil (5-FU) and subsequently to 5-fluorouracil monophosphate. In our study, this novel vector was evaluated using different human-derived cholangiocarcinoma cell lines. In vitro, all cholangiocarcinoma cell lines were found to be permissive to MeV infection. Partial blocking of MeV-mediated oncolysis due to primary resistance mechanisms often found inherently in tumor cells could be over come by employment of the SCD transgene together with administration of 5-FC. In vivo, intratumoral application of SCD-armed MeV together with a systemic 5-FC treatment showed a significant reduction in tumor size in a TFK-1 xenograft mouse model when compared to virus-only treatment. In a second animal experiment employing a HuCCT1 xenograft tumor model, an expression enhanced SCD-armed MeV vector, in which the transgene was expressed from genome position one, not only led to reduced tumor volumes, but also to a significant survival benefit. On basis of these encouraging preclinical data on employment of SCD-armed MeV for the virotherapeutic treatment of chemotherapy-resistant cholangiocarcinoma, a clinical virotherapy trial is set up currently.
Formulation and Evaluation of Colon Targeted Tablets of Ornidazole For The Treatment Of Amoebiasis (2011)

Ornidazole is used for the management of amoebiasis. The site of absorption of Ornidazole is in the whole GI tract and has a long half life of 13 h. The aim of the study was to develop colon targeted film coated tablets of Ornidazole using HPMC K100, Eudragit S 100, and Ethyl cellulose as carriers in the treatment of amoebiasis. All the formulations (F1 to F8) were evaluated for the physicochemical parameters and were subjected to in vitro drug release studies. The amount of Ornidazole released from tablets at different time intervals was estimated by UV spectrophotometer. The formulation F7 released 99.38 % of Ornidazole. The results of the study showed that formulation F7 is most likely to provide targeting of Ornidazole for local action in the colon owing to its minimal release of the drug in the first 5 h. The most satisfactory formulation was stable during stability studies conducted for 60 days as per ICH guidelines. It showed no significant changes in the physicochemical parameters, in vitro release pattern.
Characterization of triplet sublevels by Highly resolved vibrational satellite structures. Application to Pt(2-thpy)2 (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCharacterization of triplet sublevels by Highly resolved vibrational satellite structures. Application to Pt(2-thpy)2Harald Wiedenhofer, Stefan Schuetzenmeier, Alex von Zelewsky, and Hartmut YersinCite this: J. Phys. Chem. 1995, 99, 36, 13385–13391Publication Date (Print):September 1, 1995Publication History Published online1 May 2002Published inissue 1 September 1995https://pubs.acs.org/doi/10.1021/j100036a011https://doi.org/10.1021/j100036a011research-articleACS PublicationsRequest reuse permissionsArticle Views264Altmetric-Citations64LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Fluorierte Aminosäuren, IV. Darstellung von C‐Perfluoralkyl‐glycinen und 3.3.3‐Trichlor‐alanin (1970)

Abstract Eine allgemeine Synthese von C ‐Perfluoralkyl‐glycinen 1 wird beschrieben, die über N ‐Acyl‐aldimine 2 , 3‐Amino‐3‐perfluoralkyl‐ N ‐acyl‐propene‐ (1) 8 und C ‐ Perfluoralkyl‐ N ‐acyl‐glycine 9 verläft. Analog läßt sich auch 3.3.3‐ Trichlor‐alanin ( 13 ) herstellen.
Whole-Genome Sequences of Two Borrelia afzelii and Two Borrelia garinii Lyme Disease Agent Isolates (2011)

Human Lyme disease is commonly caused by several species of spirochetes in the Borrelia genus. In Eurasia these species are largely Borrelia afzelii, B. garinii, B. burgdorferi, and B. bavariensis sp. nov. Whole-genome sequencing is an excellent tool for investigating and understanding the influence of bacterial diversity on the pathogenesis and etiology of Lyme disease. We report here the whole-genome sequences of four isolates from two of the Borrelia species that cause human Lyme disease, B. afzelii isolates ACA-1 and PKo and B. garinii isolates PBr and Far04.
Stabilization of Granulocyte Colony-Stimulating Factor and Structurally Analogous Growth Factors by Anionic Phospholipids (1996)

Recombinant granulocyte colony-stimulating factor (rhG-CSF) interacts with liposomes composed of the anionic phospholipid dioleoylphosphatidylglycerol (DOPG), and this interaction enhances the stability of the protein [Collins, D., & Cha, Y. (1994) Biochemistry 33, 4521-4526]. In the present studies, we have examined the interaction of rhG-CSF with phospholipids other than DOPG. Fluorescence spectroscopy of rhG-CSF with a variety of lipid vesicles demonstrated that rhG-CSF inserts into bilayers of anionic, but not zwitterionic, phospholipids. Isothermal titration calorimetry of the interaction between DMPG and rhG-CSF indicates that the binding is saturable and involves 10 lipids/rhG-CSF. Studies of phosphatidylglycerols with varying alkyl chain lengths determined that the stabilization of rhG-CSF by anionic phospholipids required a certain alkyl chain length; no stabilization was observed with lipids of shorter chain length. Also investigated was the stabilization of other growth factors, which are structurally similar to rhG-CSF, by anionic phospholipids. These proteins include recombinant porcine somatotropin (rpSt), recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF), recombinant human interleukin 4 (rhIL-4), and recombinant human interleukin 2 (rhIL-2). The helical secondary structure of the proteins was recoverable after heating and cooling in the presence of anionic phospholipids as observed by circular dichroism; the presence of zwitterionic lipids did not induce this effect. Results of these investigations concluded that a group of structurally similar proteins interact preferentially with anionic phospholipids and that the complexation of the growth factors with vesicles composed of anionic phospholipids improves the stability of the proteins under conditions where they normally denature.
Aterosklerotik Plakların Teşhis Ve Tedavisinde Kullanılmak Üzere Biyokimyasal Olarak Modifiye Edilmiş Nanoplatformların Hazırlanması Ve Karakterizasyonu (2013)

Cardiovascular diseases are some of the leading causes of death all over the world, and the prevalence is expected to increase further during the next years. For early detection of atherosclerotic unstable plaques will be a great value in order to reduce the morbidity mortality level in affected patients. With the developing technology nanomaterials aimed to develop to be used in the early diagnosis of atherosclerosis. In recent studies, magnetic resonance imaging (MRI) plays an important role in the anatomical and functional investigation of large vessels. Instead of conventional MRI contrast agents, non-toxic and biocompatible iron oxide nanoparticles have been started to use in the clinic. However, the uptake of these agents are nonspecific, so the labeling efficiency for plaques in vivo is not ideal. Iron oxide nanoparticles are modified with biocompatible polymeric materials such as dextran, chitosan, etc., and used in vivo applications.
Switchgear optimization using IEC 61850-9-2 (2013)

This document describes the utilization of the nonconventional measurements and advanced features of IEC 61850 standard for substation automation systems, especially how sampled value sending according standard part 9-2 can be used between IEDs in medium-voltage substation to improve the reliability and functionality of the system. Calculated results indicate improvements on availability, performance and reliability with the selected application example, busbar voltage sharing. (4 pages)
Magnetic resonance imaging spectrum of succinate dehydrogenase–related infantile leukoencephalopathy (2015)

Succinate dehydrogenase deficiency is a rare leukoencephalopathy, for which improved recognition by magnetic resonance imaging (MRI) in combination with advanced sequencing technologies allows noninvasive diagnostic confirmation. The MRI pattern is characterized by cerebral hemispheric white matter abnormalities with sparing of the U fibers, corpus callosum involvement with sparing of the outer blades, and involvement of corticospinal tracts, thalami, and spinal cord. In individuals with infantile regression and this pattern of MRI abnormalities, the differential diagnosis should include succinate dehydrogenase deficiency, in particular if MRS shows elevated succinate.
Experimental results performed in the framework of the HIPER European Project (2011)

This paper presents the goals and some of the results of experiments conducted within the Working Package 10 (Fusion Experimental Programme) of the HiPER Project. These experiments concern the study of the physics connected to "Advanced Ignition Schemes", i.e. the Fast Ignition and the Shock Ignition Approaches to Inertial Fusion. Such schemes are aimed at achieving a higher gain, as compared to the classical approach which is used in NIF, as required for future reactors, and making fusion possible with smaller facilities. In particular, a series of experiments related to Fast Ignition were performed at the RAL (UK) and LULI (France) Laboratories and were addressed to study the propagation of fast electrons (created by a short-pulse ultra-high-intensity beam) in compressed matter, created either by cylindrical implosions or by compression of planar targets by (planar) laser-driven shock waves. A more recent experiment was performed at PALS and investigated the laser-plasma coupling in the 10<sup>16</sup> W/cm<sup>2</sup> intensity regime of interest for Shock Ignition.
SOLID PHASE EXTRACTION OF β2-AGONISTS FROM URINE WITH MOLECULAR IMPRINTS. (1999)

Department of Analytical Chemistry and Toxicology, University Centre for Pharmacy, Groningen, The Netherlands.
New paradigms in the management of alloimmune refractoriness to platelet transfusions (2007)

This review presents a literature-based algorithm with which to approach the management of platelet refractory individuals, focusing on newer technology to maximize the post-transfusion yield of matched units. Strategies are presented that allow selection of more effective products for difficult, broadly alloimmunized individuals, including patients who have developed antibodies to human platelet antigens.
A convenient method for securely managing passwords (2005)

Computer users are asked to generate, keep secret, and recall an increasing number of passwords for uses including host accounts, email servers, e-commerce sites, and online financial services. Unfortunately, the password entropy that users can comfortably memorize seems insufficient to store unique, secure passwords for all these accounts, and it is likely to remain constant as the number of passwords (and the adversary's computational power) increases into the future. In this paper, we propose a technique that uses a strengthened cryptographic hash function to compute secure passwords for arbitrarily many accounts while requiring the user to memorize only a single short password. This mechanism functions entirely on the client; no server-side changes are needed. Unlike previous approaches, our design is both highly resistant to brute force attacks and nearly stateless, allowing users to retrieve their passwords from any location so long as they can execute our program and remember a short secret. This combination of security and convenience will, we believe, entice users to adopt our scheme. We discuss the construction of our algorithm in detail, compare its strengths and weaknesses to those of related approaches, and present Password Multiplier, an implementation in the form of an extension to the Mozilla Firefox web browser.
Carbonization Study of Different Silicon Orientations (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
[Usage of chitosan as a pharmaceutical material effectiveness as an additional additives of sodium alginate]. (1990)

Application of chitosan, a deacetylated compound of chitin obtained from shells of shrimps, was investigated with reference to the pharmaceutical excipient for directly compressed tablets. Several drugs were chosen as model compounds and their in vitro dissolution tests were carried out according to the JP XI dissolution test. When chitosan was used alone as an excipient, immediate-release tablets were obtained, as already reported. But when more than 5% of sodium alginate, 1000 cps, was added as excipient, tablets showed an extended-release property under the present experimental conditions.
ASSEMBLY OF MITOCHONDRIAL PROTEINS: MEMBRANE TRANSLOCATION, FOLDING AND DEGRADATION (1996)

Conference Abstract| November 01 1996 ASSEMBLY OF MITOCHONDRIAL PROTEINS: MEMBRANE TRANSLOCATION, FOLDING AND DEGRADATION W. Neupert W. Neupert 1Institut für Physiologische Chemie, Universitaet München, Goethestrasse 33, D-80336 München, Germany Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1996) 24 (4): 627S. https://doi.org/10.1042/bst024627sa Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation W. Neupert; ASSEMBLY OF MITOCHONDRIAL PROTEINS: MEMBRANE TRANSLOCATION, FOLDING AND DEGRADATION. Biochem Soc Trans 1 November 1996; 24 (4): 627S. doi: https://doi.org/10.1042/bst024627sa Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1996 Biochemical Society1996 Article PDF first page preview Close Modal You do not currently have access to this content.
DADO: enhancing middleware to support crosscutting features in distributed, heterogeneous systems (2003)

Some non- or extra-functional features, such as reliability, security, and tracing, defy modularization mechanisms in programming languages. This makes such features hard to design, implement, and maintain. Implementing such features within a single platform, using a single language, is hard enough With distributed, heterogeneous (DH) systems, these features induce complex implementations which cross-cut different languages, OSs, and hardware platforms, while still needing to share data and events. Worse still, the precise requirements for such features are often locality-dependent and discovered late (e.g., security policies). The DADO/sup 1/ approach helps program cross-cutting features by improving DH middleware. A DADO service comprises pairs of adaplets which are explicitly modeled in IDL. Adaplets may be implemented in any language compatible with the target application, and attached to stubs and skeletons of application objects in a variety of ways. DADO supports flexible and type-checked interactions (using generated stubs and skeletons) between adaplets and between objects and adaplets. Adaplets can be attached at run-time to an application object. We describe the approach and illustrate its use for several cross-cutting features, including performance monitoring, caching, and security. We also discuss software engineering process, as well as run-time performance implications.
Failure isolation using an associative memory algorithm (1986)

This paper proposes the application of an associative memory algorithm for the identification and isolation of system failures. It is assumed that the system is time-invariant and that prior to the occurrence of the failure all signals are stationary random processes. It is also assumed that the fact that a failure has occurred and its time of occurrence are both known, from some other method. The associative memory algorithm assumes that all possible failure modes are known their signatures have been Stored in a random-access memory and feedback is used to provide a search algorithm. The combination of the memory and the feedback loop produce a dynamic associative memory whose output is a "nearest neighbor" of the actual failure mode.
Periodic dispersion management in sollton WDM transmission with sliding filters (2005)

CThI3 Fig. 2 Dependence of the dispersionmanaged soliton interaction length on the parameter y. The squares correspond to the initial pulse separation 3~~, and the circles correspond to 47. The triangles show the interaction length for the pulses that have an initial T phase difference. The interaction length is normalized to an ideal soliton period. uniform a (a) rl00
The predictive power of free (vs. total) testosterone in aggressive prostate cancer. (2019)

e16570 Background: The role of testosterone in prostate growth and the development of prostate cancer is a controversial topic. Most current data suggest that lower testosterone leads to higher grade conversion, whereas higher testosterone may serve a protective role in preventing both development and recurrence. We seek to analyze whether free testosterone (FT) values can predict aggressiveness in prostate cancers. Methods: We retrospectively reviewed 830 patients who presented to a single surgeon for evaluation and management of prostate cancer. Total Testosterone (TT) and FT values were obtained on each patient at initial visit. All patients underwent radical prostatectomy and samples from surgery were sent for grading and staging. Patients were stratified by FT quartile (25 th [≤ 4.42 ng/dL], 50 th [4.43 – 5.60 ng/dL], 75 th [5.61 – 6.95 ng/dL], and 100 th [≥ 6.96 ng/dL]). Results: Of 830 patients, 168 (22.2%), 330 (39.8%), 188 (22.7%), 46 (5.5%), and 98 (11.8%) had GS 3+3, 3+4, 4+3, 4+4, and ≥4+5, respectively. Mean FT values for each Gleason grade group (GGG) were significantly different (p = 0.008). Mean FT was also lower in patients with higher stage disease (p = 0.01). In contrast, TT did not differ significantly among GGG (p = 0.489) or stage (p = 0.670). Patients who had a FT level in the lowest quartile (≤ 4.42 ng/dL) had a higher proportion of GGG 5 (15.6%) than patients in the highest quartile (≥ 6.96 ng/dL) (6.2%) (p = 0.002). After adjusting for age, prostate specific antigen (PSA), and body mass index (BMI) in multivariate analysis, lower FT was a significant predictor of high-risk score 9-10 (OR: 0.912, 95% CI: 0.836-0.994, p = 0.036). These trends showed strong correlation in pathologic stage (p = 0.057), but larger numbers are needed to gauge effect size. Conclusions: Based on our data, biochemically low FT may be a risk factor for high grade and high stage cancer. These results have implications for the current recommendations for testosterone therapy, which is contraindicated in men with prostate cancer. [Table: see text]