gebhart/patrepeval huggingface dataset:
Supplementary Data from Loss of Function of DOCK4 in Myelodysplastic Syndromes Stem Cells is Restored by Inhibitors of DOCK4 Signaling Networks (2023)

&lt;p&gt;Supplemental figure 2: A) Flow cytometry analysis showing that the TF1 erythroleukemia cells express high levels of CD34 marker on their cell surface. B) Twenty four hours post DOCK4 siRNA nucleofection, cells were used for immunoblot analysis for DOCK4 expression. Data are mean {plus minus}SEM from five independent experiments. C) Twenty four hours post DOCK4 knockdown, TF1 cells were briefly deprived of cytokines and then re-exposed to a cytokine cocktail (Stem cell factor (SCF), Interleukin-3 (IL-3) and Granulocyte-Macrophage colony stimulating factor (GM-CSF)) for 15 mins. Samples were resolved by immunoblotting for phospho-LYN (Y397), phospho-SHIP1 (Y1021) and phospho-SHP1 (Y536). Same membranes were probed with total LYN, SHIP1 and SHP1 antibodies as loading controls. D, E and F) Quantitation of the levels of phospho-LYN (Y397) (N=3), phospho-SHIP1 (Y1021) (N=5) and phospho-SHP1 (Y536) (N=4) respectively in TF1 cells from control and DOCK4 knocked down samples (*P &lt; 0.05; Student's t test). Data are mean {plus minus}SEM from independent experiments as specified. G) Twenty four hours post DOCK4 knockdown HSCs were briefly deprived and exposed to 5 cytokine cocktails (TPO, SCF, FLT3 ligand, IL3 and IL6) for 15 mins. Following cytokine exposure, LYN kinase activity assay was performed to examine the endogeneous LYN kinase activity in HSCs expressing normal and reduced levels of DOCK4 (*P &lt; 0.05; Student's t test). Data are represented as mean {plus minus}SEM from three technical replicates. H) Quantitation of the levels of phospho-SHIP1 (Y1021) in the in vitro kinase reaction products (***P &lt; 0.0005; One way ANOVA). Data are mean {plus minus}SEM from three independent experiments. I) Quantitation of the levels of phospho-SHP1 (Y536) in the in vitro kinase reaction products (***P &lt; 0.0005; One way ANOVA). Data are mean {plus minus}SEM from three independent experiments. J, K and L) Quantitation of the levels of phospho-LYN (Y397), phospho-SHIP1 (Y1021), and phospho-SHP1 (Y536) respectively in primary human HSCs treated with increasing doses of LYN/Src inhibitor, RK20449. Data are mean {plus minus}SEM from three biological replicates (****P &lt; 0.00005, One way ANOVA; ns-not significant). M) LYN kinase activity assay was performed using recombinant LYN kinase and increasing amounts of recombinant DOCK4 C-terminus. JAK2 kinase and LYN/Src inhibitor were used as controls. Data are mean {plus minus}SEM from three independent experiments. (**P &lt; 0.005; One way ANOVA). N) An in vitro binding assay was performed using flag-tagged DOCK4 C-terminus (D4CT) and recombinant LYN kinase to determine whether LYN kinase interacted with DOCK4-C-terminus. Samples were immunoprecipitated with anti-Flag antibody followed by immunoblot analysis using anti-Flag and anti-LYN antibodies.&lt;/p&gt;
ChemInform Abstract: THE ′UNCATALYZED′ OXIDATION OF SULFUR(IV) IN AQUEOUS SOLUTIONS (1978)

Abstract Bei Verwendung geringer Mengen der Chelatbildner EDTA oder 1.10‐Phenanthrolin zur Komplexierung von Spurenverunreinigungen durch Metallionen wird die Geschwindigkeit der bisher als nichtkatalysiert eingestuften Oxidation von wäßrigen Sulfit‐Lösungen bei hohem pH bis zu 4 Größenordnungen und bei niedrigem pH um einen Faktor 20 reduziert, d. h. die Reaktion wird eben doch katalysiert und zwar durch die Metallspuren.
An Adaptive Neuro-Fuzzy System with Semi-Supervised Learning as an Approach to Improving Data Classification: An Illustration of Bad Debt Recovery in Healthcare (2015)

Business analytics has become an increasingly important priority for organizations today as they strive to achieve greater competitiveness. As organizations adopt business practices that rely on complex, large-scale data, new challenges also emerge. A common situation in business analytics is concerned with appropriate and adequate methods for dealing with unlabeled data in classification. This study examines the effectiveness of a semi-supervised learning approach to classify unlabeled data to improve classification accuracy rates. The context for our study is healthcare. The healthcare costs in the U.S. have risen at an alarming rate over the last two decades. One of the causes for the rising costs could be attributed to medical bad debt, i.e., debt that is not recovered by healthcare institutions. A major obstacle to debt classification, hence better debt recovery, is the presence of unlabeled cases, a situation not uncommon in many other business contexts. There is surprisingly very little research that explores the performance of computational intelligence and soft computing methods in improving bad debt recovery in the healthcare industry. Using a real data set from a healthcare organization, we address this important research gap by examining the performance of an adaptive neuro-fuzzy inference system (ANFIS) with semi-supervised learning (SSL) in improving debt recovery rate. In particular, this study explores the role of ANFIS in conjunction with SSL in classifying unknown cases (those that were not pursued for debt collection) as either a good case (recoverable) or a bad case (unrecoverable). Healthcare institutions can then pursue these potentially good cases and improve their debt recovery rates. Test results show that ANFIS with SSL is a viable method. Our models generated better classification accuracy rates than those in prior studies. These results and their analysis show the potential of ANFIS with SSL models in classifying unknown cases, which are a potential source of revenue recovery for health care organizations. The significance of this research extends to all types of organizations that face an increasingly urgent need to adopt reliable practices for business analytics.
Correction to "On the convergance of the conjugate gradient method in Hilbert space" (1969)

In an earlier correspondence a "proof" of convergence for the conjugate gradient method was given. This correspondence points out an error and states a slightly weaker version of the theorem which is correctly proven.
Two-port multispectral imaging system for contaminant detection on poultry carcasses (2006)

The objective of this research is to design and fabricate a compact, cost effective multispectral instrument and to collect and analyze spectra for real-time contaminant detection for poultry processing plants. It was revealed by our previous research that the fecal contamination on the surface of the poultry carcass could be detected by sensing the spectral reflectance of the carcass surface in two specific wavelengths, namely 517 nm and 565 nm. The prototype system developed in this research consists of a multispectral imaging system, illumination system and handheld PC. To develop the system cost-effectively, all components are selected from off-the-shelf products and manually assembled. The multispectral imaging sensor developed in this research is a two-port imaging system that consists of two identical monochrome cameras, optical system and two narrow bandpass filters whose center of the wavelength are 520 and 560 nm, respectively. A spectral reflectance from a chicken carcass is collected and split in two directions by an optical system including a beamsplitter and lenses, and then two identical collimated lights are filtered by the narrow bandpass filters and delivered to the cameras. Lens distortions and geometric misalignment of the two cameras are mathematically compensated to register two images perfectly. The prototype system is tested in the real environment and shows that it can effectively detect feces and ingesta on the surface of poultry carcasses.
Security in the Ajanta mobile agent system (2001)

Abstract A mobile agent is an object which can autonomously migrate in a distributed system to perform tasks on behalf of its creator. Security issues in regard to the protection of host resources, as well as the agent themselves, raise significant obstacles in practical applications of the agent paradigm. This article describes the security architecture of Ajanta, a Java‐based system for mobile agent programming. This architecture provides mechanisms to protect server resources from malicious agents, agent data from tampering by malicious servers and communication channels during its travel, and protection of name service data and the global namespace. We present here a proxy based mechanism for secure access to server resources by agents. Using Java's class loader model and thread group mechanism, isolated execution domains are created for agents at a server. An agent can contain three kinds of protected objects: read‐only objects whose tampering can be detected, encrypted objects for specific servers, and a secure append‐only log of objects. A generic authentication protocol is used for all client–server interactions when protection is required. Using this mechanism, the security model of Ajanta enforces protection of namespaces, and secure execution of control primitives such as agent recall or abort. Ajanta also supports communication between agents using RMI, which can be controlled if required by the servers' security policies. Copyright © 2001 John Wiley &amp; Sons, Ltd.
Traumatic communication of the extensor carpi radialis tendon sheath and antebrachiocarpal joint in two horses (2015)

Summary Two horses were examined due to lacerations at the level of the craniodistal antebrachii. Further evaluation of the lacerations revealed communication with the extensor carpi radialis tendon sheath and potentially the antebrachiocarpal joint. Positive contrast arthrography performed via the palmarolateral pouch of the antebrachiocarpal joint was used to diagnose communication with the extensor carpi radialis tendon sheath. Both the joints and tendon sheaths were treated aggressively with surgical debridement and lavage, followed by post operative medical management and rehabilitation. Both horses made a full recovery and are performing in their intended level of use with acceptable cosmetic results. Traumatic communication with the carpal joints should be considered when evaluating lacerations involving the forelimb extensor tendon sheaths.
Idiopathic Dilated Cardiomyopathy (1994)

Idiopathic dilated cardiomyopathy (IDC) is a primary myocardial disease of unknown cause characterized by left ventricular or biventricular dilatation and impaired myocardial contractility1. Depending on the diagnostic criteria used, the reported annual incidence varies between 5 and 8 cases per 100,000 population25. However, the true incidence is probably underestimated by those figures, since many asymptomatic cases remain unrecognized. The age-adjusted prevalence of IDC in the United States averages 36 cases per 100,000 population,5 and it accounts for 10,000 deaths annually2.Blacks and males have a 2.5-fold increase in risk, as compared with whites and females, that . . .
Wideband Slot Antenna for Low-Profile Hand-held Terminal Applications (2006)

A quarter-wave transversal slot in the center of a handheld terminal ground plane is proposed and evaluated as a wideband antenna for low profile mobile phones. By feeding the slot with a microstrip line, a triple-resonance response is obtained from the chassis, slot and microstrip stub interaction, providing sufficient impedance bandwidth and radiation efficiency to cover the 0.9-2.7 GHz frequency range. While the introduction of a slot in the ground plane has many advantages over e.g. PIFA or patch structures, both in terms of performance and cost, the circuit floor planning becomes more complicated. To address this problem, a possible solution in terms of module partitioning and signal line routing is suggested. In addition, simulations of parasitic antenna to signal line coupling and techniques to reduce this effect are presented
Pendrin, encoded by Slc26a4 , modulates ENaC expression and function (2007)

Pendrin, encoded by Slc26a4 , mediates renal Cl − absorption across non‐A intercalated cells, through Cl − /HCO 3 − exchange, which increases blood pressure. Because aldosterone–induced hypertension occurs by increasing both Cl − (e.g. pendrin) and Na + transporter expression, we asked if Na + transporter expression is altered in kidney from aldosterone‐treated Slc26a4 null mice. Thus, wild type and Slc26a4 null mice were given a NaCl‐replete, a NaCl‐restricted, or a NaCl‐replete diet and aldosterone or aldosterone analogues. Expression of the major renal Na + transporters was examined using immunoblots and immunohistochemistry. Following each of these treatments, expression of NHE3, NKCC1/2, and NCC were similar in mutant and wild type mice. Renal ENaC subunit expression increased, as expected, in response to aldosterone in both Slc26a4 null and wild type mice. However, expression of all 3 ENaC subunits and ENaC‐mediated current were markedly reduced in kidneys from Slc26a4 null relative to wild type mice under each condition tested. ENaC expression was similar, however, in thyroid tissues from wild type and mutant mice. We conclude that within kidney, but not thyroid, pendrin modulates ENaC expression. This reduced ENaC expression likely contributes to the lower blood pressure in Slc26a4 null mice in response to aldosterone.
Genetic and physical map of a P1 miniplasmid (1982)

The prophage form of bacteriophage P1 is a unit-copy plasmid which is maintained with great fidelity in its Escherichia coli host. The plasmid maintenance functions of P1 are clustered in one region of the genome. An 11.5-kilobase fragment from this region has been cloned into a lambda delta att vector and promotes stable unit-copy plasmid maintenance. The properties of the lambda vector facilitated the isolation of deletion mutants affecting the P1 DNA. Twenty-eight deletion mutants were isolated, and their lesions were mapped by physical techniques. The genetic properties of the mutants with respect to plasmid replication, stability of plasmid maintenance, and ability to exert incompatibility effects against P1 and P7 plasmids were determined. These properties, along with those of several subfragments of the P1 insert cloned into high-copy-number plasmid vectors, allow the construction of an unambiguous genetic and physical map of the maintenance functions. A region of less than 3 kilobases, the rep region, is essential for plasmid replication and contains the incA incompatibility determinant within an 800-base-pair segment. Immediately adjacent to rep is a second region of approximately 3 kilobases which is required for stable plasmid maintenance, but not replication. This region, par, contains a second incompatibility element incB which is approximately 1 kilobase in size. The par region appears to specify equipartition of plasmid copies to daughter cells during cell division.
Age Distribution in Arbitrary Preemptive Memoryless Networks (2022)

We study the probability distribution of age of information (AoI) in arbitrary networks with memoryless service times. A source node generates packets following a Poisson process, and then the packets are forwarded across the network in such a way that newer updates preempt older ones. This model is equivalent to gossip networks that were recently studied by Yates, and for which he obtained a recursive formula allowing the computation for the average AoI. In this paper, we obtain a very simple characterization of the stationary distribution of AoI at every node in the network. This allows for the computation of the average of an arbitrary function of the age, such as the age-violation probabilities. Furthermore, we show how our simple characterization can yield substantial reductions in the computation time of average AoIs in some structured networks. Finally, we describe how it can yield faster and more accurate Monte Carlo simulations estimating the average AoI, or the average of an arbitrary function of the age.
The nature and function of interoceptive signals to feed: Toward integration of physiological and learning perspectives. (1993)

The idea that different states of energy need give rise to distinct interoceptive sensations has been basic to many accounts of the physiological and the learned controls of feeding. Yet, a number of difficulties have complicated attempts to provide direct evidence for this view. The present article describes a research strategy that confirms that food deprivation states produce salient interoceptive stimuli in rats. The implications of this research for the physiological origins of energy state signals, the brain structures involved with processing energy state information, and the manner in which signals of energy need influence feeding were considered. The possibility that food deprivation cues influence feeding by modulating the activation of associations involving external events and their postingestive aftereffects was discussed with reference to earlier associative accounts of the function of hunger signals.
Alzheimer's disease: Clinical implications of the apolipoprotein E genotype (1997)

Inheritance of the apolipoprotein E (APOE = gene; apoE = protein) epsilon 4 gene is associated with a higher risk for development of Alzheimer's disease (AD) and for occurrence of this illness at a younger age. APOE gene dose and genotype interact with gender, ethnicity, and age to influence the probability of developing AD, as well as the rate of disease progression. The sensitivity and specificity of APOE genotyping, however, and the longer-term implications of the epsilon 4 allele as a susceptibility factor for AD, are not yet adequately understood to recommend the use of APOE genotyping in genetic counseling of asymptomatic family members of AD patients. Insufficient evidence also exists at this time to recommend APOE genotyping as an adjuvant for the differential diagnosis of dementia or as a possible predictor for response to drug therapy. These potential future clinical indications for apoE genotyping are under active investigation.
A Reed-Solomon product-code (RS-PC) decoder chip for DVD applications (2001)

In this paper, a Reed-Solomon Product-Code (RS-PC) decoder for DVD applications is presented. It mainly contains two frame-buffer controllers, a (182, 172) row RS decoder, and a (208, 192) column RS decoder. The RS decoder features an area-efficient key equation solver using a novel modified decomposed inversionless Berlekamp-Massey algorithm. The proposed RS-PC decoder solution was implemented using 0.6 /spl mu/m CMOS single-poly double-metal (SPDM) standard cells. The chip size is 4.22/spl times/3.64 mm/sup 2/ with a core area of 2.90/spl times/2.88 mm/sup m/m/sup 2/, where the total gate count is about 26 K. Test results show that the proposed RS-PC decoder chip can support 4/spl times/DVD speed with off-chip frame buffers or 8/spl times/DVD speed with embedded frame buffers operating at 3 V.
A Clinical and Radiographic Assessment of a Porous-surfaced, Titanium Alloy Dental Implant System in Dogs (1986)

A new endosseous dental implant system incorporating a porous-surface geometry with a tapered, truncated-cone shape was placed bilaterally in edentulous areas of dog mandibles in a two-stage procedure. All implants had been stabilized by bone ingrowth by the time of the second procedure (insertion of a transgingival collar and implant-supported bridge). The transgingival collar had a porous-surface geometry on its apical one-third, and was meant to encourage gingival connective tissue ingrowth and attachment, but in fact provided an excellent milieu for bacterial contamination. As a consequence, many of the implants showed clinical and radiographic signs of impending failure by eight months. Only those implants for which the porous coat, including that of the transgingival collar, was completely submerged in bone were observed to be successful. This study reports on the radiographic and clinical assessment of this implant system in dogs during the period of function.
Percorso rapido per la validazione di analizzatori automatici per test immunoenzimatici in micropiastra (2007)

The introduction of new diagnostic instruments in the Microbiology Laboratory imposes a trial period which must precede introduction in the routine. This period is aimed to minimize any organizational difficulty and/or staff distress. In this context, we suggest an organizational model that can quickly evaluate accuracy, repeatability and carry over of new diagnostic instruments.
New Regressors for the Direct Identification of Tire Deformation in Road Vehicles Via “In-Tire” Accelerometers (2008)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> The interaction between the tire and the road is crucial for determining the dynamic behavior of a road vehicle, and the road–tire contact forces are key variables in the design of traction, braking, and stability control systems. Traditionally, road–tire contact forces are indirectly estimated from vehicle-dynamics measurements (chassis accelerations, yaw-roll rates, suspension deflections, etc.). The emerging of the “smart-tire” concept (tire with embedded sensors and digital-computing capability) has made possible, in principle, a more direct estimation of contact forces. In this field—still in its infancy—the main open problems are the choice of the sensor(s) and the choice of the regressor(s) to be used for force estimation. The objective of this work is to present a new sensor–regressor choice, and to provide some preliminary experimental results, which confirm the validity of this choice. The idea is to use a wheel encoder and an accelerometer mounted directly in the tire. The measurement of the in-tire acceleration is transmitted through a wireless channel. The key innovative concept is to use the phase shift between the wheel encoder and the pulse-like signals provided by the accelerometer as the main regressor for force estimation. </para>
Study on the Relationship between Abnormal Alteration of Abdominal Ultrasonography and Clinical Manifestations in 1200 Patients with Wilson's Disease (2003)

Aim: To study the relationship between the abnormal alteration of abdominal ultrasonography and clinical manifestations in patients with Wilson's disease (WD) . Methods:We have examined 1 200 patients with WD by ultrasonography, analyzed the relationship among all types of abnormal alteration of abdominal ultrasonography, and compared the alterations with clinical data. Results: The rate of abnormal alterations of ultrasonography of the liver was 100%, they could be divided into seven types. Spleen tumefaction was found in 939 cases (79.8%); chronic cholecystitis was found in 253 cases (21.1%); gallbladder cliff edema was found in 107 cases (8.9%); cholelithiasis was found in 64 cases (5.3%); the amount of kidneys whose echoes were increased, roughened, strengthened was 515 (42.9%); and hydroperitonia was found in 120 cases (10%). The comparison between the abnormal alterations of livers ultrasonography and the clinical data indicated that the changes of ultrasonography be related with symptoms of WD significanly ( P 0.01). Conclusion: The patients with WD have high frequency of abnormal alteration of abdominal ultrasonography. If a younger has symptoms of hepatitis, cirrhosis, spleen tumefaction, spleen function excessive and nephritis with unknown origin, and also has abnormal alteration of abdominal ultrasonograph described in this article, he should be checked cornea K-F ring and copper metabolism to evacuate WD.