gebhart/patrepeval huggingface dataset:
Visceral adipose tissue modulates mammalian longevity (2008)

Caloric restriction (CR) can delay many age-related diseases and extend lifespan, while an increase in adiposity is associated with enhanced disease risk and accelerated aging. Among the various fat depots, the accrual of visceral fat (VF) is a common feature of aging, and has been shown to be the most detrimental on metabolic syndrome of aging in humans. We have previously demonstrated that surgical removal of VF in rats improves insulin action; thus, we set out to determine if VF removal affects longevity. We prospectively studied lifespan in three groups of rats: ad libitum-fed (AL-fed), CR (Fed 60% of AL) and a group of AL-fed rats with selective removal of VF at 5 months of age (VF-removed rats). We demonstrate that compared to AL-fed rats, VF-removed rats had a significant increase in mean (p < 0.001) and maximum lifespan (p < 0.04) and significant reduction in the incidence of severe renal disease (p < 0.01). CR rats demonstrated the greatest mean and maximum lifespan (p < 0.001) and the lowest rate of death as compared to AL-fed rats (0.13). Taken together, these observations provide the most direct evidence to date that a reduction in fat mass, specifically VF, may be one of the possible underlying mechanisms of the anti-aging effect of CR.
Contribution of left ventricular contraction to the generation of right ventricular systolic pressure in the human heart. (1985)

To determine whether left ventricular (LV) contraction contributes to the generation of right ventricular (RV) systolic pressure in humans, LV and RV pressures and their first derivative (dP/dt) were recorded simultaneously with micromanometer-tipped catheters in 11 conscious subjects. Seven subjects had normal LV and coronary angiograms. Four subjects had moderate LV dysfunction (resting ejection fraction 0.40 to 0.50), and three of these had coronary artery disease. During normal sinus rhythm, LV contraction slightly preceded RV contraction (mean 20 msec), and LV and RV dP/dt recordings showed single positive systolic peaks that were coincident. During endocardial pacing of the RV free wall, RV contraction preceded LV contraction (mean 23 msec) and two systolic RV dP/dt peaks were recorded, the first (peak I) occurring significantly before (mean +/- SD = 67 +/- 23 msec, p less than .01), and the second (peak II) coincident with the single systolic LV dP/dt peak. RV ectopic beats produced a similar RV dP/dt pattern, with peak I occurring 63 +/- 11 msec (p less than .01) before, and peak II coincident with the single LV dP/dt peak. Conversely, during LV ectopic beats, LV contraction preceded RV contraction (mean 63 msec) and two systolic RV dP/dt peaks were recorded, but peak I was coincident with the single LV dP/dt peak, while peak II occurred significantly later (63 +/- 26 msec, p less than .01). In two subjects right bundle branch block produced similar findings. In three subjects left bundle branch block produced little ventricular asynchrony (mean 14 msec), but did delay the development of peak LV dP/dt after LV contraction.(ABSTRACT TRUNCATED AT 250 WORDS)
30-second chair-stand test is a valuable evaluation in chronic respiratory diseases (2014)

[Introduction] 6-Minute Walk Test (6MWT) is a valuable tool for measuring exercise tolerance in patients with chronic respiratory diseases (CRD). However, severe CRD patients often show marked depression in SpO 2 during or after walking that leads to interruption of 6MWT. Therefore we tried to evaluate their exercise tolerance by 30-second Chair-Stand Test (CS-30). CS-30 used to be performed for evaluating physical fitness in elderly who were instructed to stand up and sit down on the chair as fast as possible during a 30-second period. This study is aimed at confirming usefulness of CS-30 as one of safe assessments for exercise tolerance in CRD. [Methods] 33 patients with CRD (18 COPD / 15 IPF. Age73.7±9.6 yrs) performed 6MWT and CS-30. SpO 2 was recorded before and after the tests. In COPD, muscle strength of quadriceps was measured by hand-held dynamometer. [Results] Significant correlation between 6-minute walking distance (383.0±99.6m) and frequency of standing-up (13.9±4.4times) was found (p&lt;0.05, r=0.591).Significant difference was found in SpO 2 depression between 6MWT (-8.7±7.2%) and CS-30 (-1.7±2.0%) (p&lt;0.01).Significant difference was found in SpO 2 depression after 6MWT between COPD (-8.3±7.6%) and IPF (-.012±8.1%) (p&lt;0.05).Significant correlation between frequency of standing-up and muscle strength of quadriceps was found(p&lt;0.05, r=0.518(Rt), 0.710(Lt)). [Conclusion] CS-30 can evaluate exercise tolerance in patients with CRD like 6MWT. This study suggests that CS-30 is a valuable method to evaluate exercise tolerance in CRD patients who show SpO 2 depression with exercise.
Nonsense readthrough therapy for Duchenne muscular dystrophy (2014)

Duchenne muscular dystrophy (DMD) is the most common form of inherited muscle disease and is characterized by progressive muscle wasting ultimately resulting in death of the patients in their twenties. DMD is characterized by a deficiency of the muscle dystrophin as a result of mutations in the dystrophin gene. Currently, no effective treatment for DMD is available. Promising molecular therapies which are mutation specific have been developed. Induction of the readthrough of nonsense mutations is expected to produce dystrophin in DMD patients with nonsense mutations, which are detected in 19% of DMD cases. Clinical effectiveness of gentamicin and PTC124 have been suggested. We have demonstrated that arbekacin-mediated readthrough can substantially ameliorate muscular dystrophy. We already have begun the clinical trial of the nonsense mutation readthrough therapy using arbekacin. We hope that this molecular therapy will contribute towards the treatment for DMD.
AN INVESTIGATION OF SMALL CITIES AND TOWNS BRANDING PRACTICE: A SURVEY OF CITY ADMINISTRATION HEADS (2023)

This paper aims to study the practice of city branding in small cities and towns, and to identify the characteristics of this process through an expert survey of the heads of city administrations. For this purpose, the expert survey was conducted among the heads of small cities and towns and their deputies in charge of city development issues. The sample consisted of one representative from 33 small cities and towns in Russia. The survey used a questionnaire characterizing city branding objectives, stakeholders involved, decision-making, brand promotion measures, resources and effects. The questionnaire was developed based on the analysis of scientific and practical literature on city branding. As a result, it was revealed that, with some exceptions, branding practice in the studied cities is weakly related to the objectives of city development and has a short-term orientation. The administrations have a tendency to solve branding problems relying solely on their own resources, which leads to city branding resource constraints. These findings contribute to the city branding research by providing data on the implementation of branding practices in small cities and towns. The results also expand the practice of using municipal officials’ expertise in the city branding studies by attracting expert officials to analyse the management practice of city branding process.
Patent ductus arteriosus in infants of low birth weight. (1980)

Patent ductus arteriosus was diagnosed in 239 neonates of low birth weight (less than 2500 g) referred to the Hospital for Sick Children in a 21/2-year period. The respiratory distress syndrome was present in 77% of the group and congestive heart failure in 50%. Spontaneous closure of the defect was more frequent in those without congestive heart failure. In 48 patients whose heart failure could not be controlled by other medical therapy indomethacin was given, and in 20 (42%) it was judged successful. Surgical ligation of the ductus was performed at a median age of 30 days in 33 infants who either failed to respond to indomethacin or in whom its use was contraindicated; there were no intraoperative deaths, but 11 (33%) of the infants died 4 days to 6 months after the operation.
Ad-Hoc Endpoint Pairing Based on Simultaneous Clicking for Ubiquitous Communications (2008)

The spread of ubiquitous communications is dramatically changing the way of daily work. In this paper, we present an ad-hoc endpoint pairing method that enables a user to easily establish a pair of endpoints, such as an IP-hard phone (fixed or mobile IP-phone) and a PC-based soft phone, simply by simultaneously clicking a GUI button on the display screen of each endpoint. Using the endpoint pairing information, the user can easily launch a PC-to-PC Web/data conferencing application during a phone-to-phone audio conversation. It can thus promote deeper mutual understanding between users.
3D-4D visualisation of IoT data from Singapore’s National Science Experiment (2020)

This paper introduces Singapore Views as a novel 3D-4D interface to visualize large space-time datasets with applications in smart cities. The engine enables a combination of geographic information system, geo-located data with high-resolution 3D models and multimedia. Space-time datasets from Singapore’s National Science Experiment (NSE) 2016 are used to test the functionality of Singapore Views. The findings from the user study revealed the new visualization engine was helpful in extracting insights from space-time data. Finally, this study also contributes to the current discussion of how to visualize knowledge thereby support the planning of smart cities.
The effect of tyramine on peripheral vasculature of the spontaneously hypertensive rat (1977)

Journal Article The effect of tyramine on peripheral vasculature of the spontaneously hypertensive rat Get access N K Dadkar, N K Dadkar Department of Pharmacology, Research Centre, Hoechst Pharmaceuticals Ltd., Mulund, Bombay 400 080, India Correspondence: Department of Pharmacology, Research Centre, Hoechst Pharmaceuticals Ltd., Mulund, Bombay 400 080, India Search for other works by this author on: Oxford Academic Google Scholar A N Dohadwalla, A N Dohadwalla Department of Pharmacology, Research Centre, Hoechst Pharmaceuticals Ltd., Mulund, Bombay 400 080, India Search for other works by this author on: Oxford Academic Google Scholar B K Bhattacharya B K Bhattacharya Department of Pharmacology, Research Centre, Hoechst Pharmaceuticals Ltd., Mulund, Bombay 400 080, India Search for other works by this author on: Oxford Academic Google Scholar Journal of Pharmacy and Pharmacology, Volume 29, Issue 1, September 1977, Pages 48–49, https://doi.org/10.1111/j.2042-7158.1977.tb11238.x Published: 12 April 2011 Article history Received: 29 July 1976 Published: 12 April 2011
An isolated perfused rat kidney preparation designed for assessment of glomerular permeability characteristics (1992)

The aim of the present investigation was to modify the widely used isolated perfused rat kidney preparation to make it more suitable for studies of glomerular permeability to macromolecules. Both kidneys were perfused in situ using separate pumps in two of each other independent systems with Tyrode-solution containing human serum albumin (18.2 g l-1). Sodium nitroprusside was administered to induce dilatation and to maintain constant vascular resistance (PRU100) during the experiments. The addition of sodium nitroprusside decreased vascular resistance from 0.17 +/- 0.05 to 0.09 +/- 0.02 mmHg min-1 100 g-1 ml-1 and increased urine flow and glomerular filtration rate. The temperature of the perfusate was reduced from 37 degrees C to 8 degrees C to inhibit tubular reabsorption of protein and fluid, resulting in a urine to plasma concentration ratio of [51Cr]EDTA of 1.26 +/- 0.07. Furosemide reduced the urine to plasma concentration ratio for [51Cr]EDTA further to 1.15 +/- 0.02 and increased glomerular filtration rate. Moreover, by performing the studies at low temperatures (8 degrees C) in the presence of sodium nitroprusside and furosemide it was possible to achieve low and stable albumin fractional clearance values close to those prevailing in vivo. Thus, the described technique, allowing simultaneous perfusions of both kidneys with different solutions, pressures and flows, seem to be well suited for studies of macromolecular transport across glomerular capillaries.
Oxidative graft polymerization of aniline on the modified surface of polypropylene films (2006)

Abstract A novel method for preparing electrically conductive polypropylene‐ graft ‐polyacrylic acid/polyaniline (PP‐ g ‐PAA/PANI) composite films was developed. 1,4‐Phenylenediamine (PDA) was introduced on the surface of PP‐ g ‐PAA film, and then, chemical oxidative polymerization of aniline on PP‐ g ‐PAA/PDA film was carried out to prepare PP‐ g ‐PAA/PANI electrically conductive composite films. After each step of reaction, the PP film surface was characterized by attenuated total reflectance Fourier transform infrared spectroscopy. Static water contact angles of the PP, PP‐ g ‐PAA, and PP‐ g ‐PAA/PANI films were measured, and the results revealed that graft reactions took place as expected. The morphology of the PP‐ g ‐PAA film and the PP‐ g ‐PAA/PANI composite film were observed by atomic force microscopy. The conductivity and the thickness of the PP‐ g ‐PAA/PANI composite films with 1.5 wt % PANI were around 0.21 S/cm and 0.4 μm, respectively. The PANI on the PP‐ g ‐PAA/PANI film was reactivated and chain growing occurred to further improve the molecular weight of PANI. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 103: 2442–2450, 2007
＜Editors' Choice＞ Ultrasound measurement of thigh muscle thickness for assessment of sarcopenia. (2018)

Our aim of this study is to compare the thigh muscle thickness measurements obtained using ultrasound and bioelectrical impedance analysis (BIA) methods, and to investigate the validity and cutoff value of the ultrasonography. We analyzed a total of 201 participants (99 male and 102 female participants, mean age, 66.2 years) participated in the annual health checkup in the Yakumo Study, 2014. Thigh muscle thickness (TMT, sum of the rectus femoris and vastus intermedius muscle thickness) was measured using ultrasound at mid-thigh in the sitting position. Appendicular skeletal muscle mass (aSMI) was measured using BIA. Cutoff value of TMT was determined through the receiver operating characteristic analysis. We defined sarcopenia with the diagnostic algorithm of Asian Working Group for Sarcopenia. TMT was significantly reduced in subject with sarcopenia than in those without sarcopenia in both gender. Muscle measurements obtained using the BIA methods (aSMI) and ultrasound methods (TMT) showed a significant correlation, with a correlation coefficient of 0.38 (P < 0.001). Cutoff value, sensitivity, and specificity of TMT in diagnosis of muscle loss were 36 mm, 72.0%, and 73.9%, respectively, for the male participants, and 34 mm, 72.2%, and 72.4%, respectively, for the female participants. In conclusion, the ultrasonography for thigh muscle might be a simple diagnostic method for sarcopenia.
Intratumoral Arteriovenous Shunting in Malignant Gliomas (2001)

Important intratumoral arteriovenous shunting exists in glioblastomas. The potential consequences of this finding for intra-arterial treatment strategies are discussed.
Update on clinical and immunological features of eosinophilic gastrointestinal diseases (2011)

Clinicians should remain aware of EGIDs as a diagnostic possibility for patients with common gastrointestinal symptoms. Additional research is needed to determine mechanistic processes leading to dysfunction associated with eosinophilic gastrointestinal inflammation.
Acceleration of epithelial cell syndecan-1 shedding by anthrax hemolytic virulence factors (2006)

The concerted acceleration of shedding by several virulence factors could represent a new pathogenic mechanism contributing to disruption of epithelial or endothelial integrity, hemorrhage, edema and abnormal cell signaling during anthrax infection.
Melanoma of unknown primary: experience at Massachusetts General Hospital and Dana-Farber Cancer Institute (2005)

Melanoma may present metastatically without an identifiable primary lesion. To further characterize the epidemiology of melanoma of unknown primary (MUP), we report our experience with a cohort of MUP patients. We retrospectively reviewed patients seen at the Massachusetts General Hospital (MGH) and the Dana-Farber Cancer Institute (DFCI) between 1986 and 1996 with follow-up to 2002. Data were analysed using log-rank and proportional hazards analyses, with death from any cause as the main outcome measure. Of the 2485 melanoma patients seen, 65 (2.6%) had MUP; 41 patients were male [63.1%; 95% confidence interval (CI), 50.2%, 74.7%]. The median age at diagnosis was 54.1 years (interquartile range, 39.4-67.1 years). Thirty patients had lymph node metastases, 12 cutaneous or subcutaneous metastases and 23 visceral metastases. Of the 62 patients (95.4%) with at least some follow-up, there were 42 deaths from any cause. Patients with lymph node metastases survived significantly longer than patients with other metastases [5-year survival 38.7% (95% CI, 18.1%, 59.1%) vs. 13.9% (95% CI, 4.4%, 28.6%); P<0.01]. After adjusting for stage and age at diagnosis, there was some evidence that men survived longer than women [hazard ratio (HR)=0.55; 95% CI, 0.28, 1.09]. Survival did not differ amongst patients with different types of non-lymph node metastases. The 5-year survival rates in this cohort did not differ from those of historical controls with known primaries. The demographic and survival characteristics of this MUP cohort mirrored those found in previous studies. More studies of MUP patients, as well as a standardized definition of MUP, may shed light on the pathogenesis and prognosis of MUP.
Endo vs Exo Bowl: Complexation of Xanthone by Pyrogallol[4]arenes (2014)

Cocrystal systems containing pyrogallol[4]arene, xanthone, and solvent molecules are examined and discussed. Three types of pyrogallol[4]arenes are cocrystallized with xanthone in isopropanol, acetonitrile, dimethyl sulfoxide, and a mixture of isopropanol and methanol. It is found that the solvent controls complexation of the xanthone molecule, whereas pyrogallol[4]arene tail length affects cocrystal packing. With a single-solvent system, the xanthone molecule is outside (exo) of the bowl of the pyrogallol[4]arene, but with a two-solvent system, the xanthone molecule is inside (endo) of the bowl of the pyrogallol[4]arene.
Emission spectrometric determination of manganese and chromium in steels with a dual cathode glow discharge lamp (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEmission spectrometric determination of manganese and chromium in steels with a dual cathode glow discharge lampKazuaki. Wagatsuma and Kichinosuke. HirokawaCite this: Anal. Chem. 1989, 61, 19, 2137–2141Publication Date (Print):October 1, 1989Publication History Published online1 May 2002Published inissue 1 October 1989https://pubs.acs.org/doi/10.1021/ac00194a005https://doi.org/10.1021/ac00194a005research-articleACS PublicationsRequest reuse permissionsArticle Views72Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Indoxyl alfa-D-galactoside as the temporarily last substrate for glycosidase histochemistry. The present state of the art in histochemical glycosidase research using indoxyl glycosidas. (1990)

Initiated by the recently published histochemical method for the investigation of alfa-D-galactosidas with an indoxyl substrate, the current state of this group of synthetic compounds in light and electron microscopic histochemical glycosidase research is evaluated whereby historical, functional, methodological and applied aspects are considered. Beginning with the introduction of indoxyl acetate for non-specific esterase in 1951 and 1952 numerous other indoxyl substrates and mostly substituted in the 5- and 4-position of the indol ring by Br and Cl were developed to study histochemically non-specific phosphatases and glycosidases and frequently used in indigogenic, azoidoxyl, tetrazolium salts and metal salt techniques for catalytic (activity) histochemical and less often for immunohistochemical, affinity histochemical and hybridohistochemical purposes. The last substrate which became available and was validated for activity histochemistry was 5-Br-4-Cl-3-indoxyl alfa-1-galactoside for alfa-1-galactosidase. At present, the indoxyl glycosides are more widely used than 5-Br-4-Cl-3-indoxyl acetates and phosphates when compared with the alternative synthetic (artificial) naphthol, 6-Br-2-naphthol or ternative synthetic (artificial) naphthol, 6-Br-2-naphthol AS substrates, and among the indoxyl glycosides those for the oxoglycosidases lactase, maltase-glucoamylase, glucoamylase, acid beta-D-galactosidase, neuroaminidase and alfa-D-galactosidase are superior to other artificial compounds. When one considers in addition, electron microscopic catalytic glicosidase histochemistry (ultracytochemistry, 5-Br-4-Cl-3-indoxyl is the only suitable moiety for this purpose. These glycosidase can mostly be localized in plasma membranes or lysosomes and also measured there in tissue sections but are also found in secretion granules, endoplasmic reticulum and organ lumina.
Feedback control of nonlinear systems (1992)

Abstract This paper deals with the design of (memoryless) state‐feedback laws for systems modelled by nonlinear differential equations which are affine in the inputs. The purpose of the design is to obtain a (locally) internally stable closed‐loop system in which the effect of exogenous inputs on a prescribed error (or, more in general, on a penalty variable) is attenuated. Two standard setups are considered: in the first one, the ratio between the energy associated with the penalty variable and that associated with the exogenous input is required to be bounded by a constant 0 &lt; γ this setup includes (to some extent) the standard H ∞ control problem of linear system theory. In the second one, the penalty variable is required to converge to 0 as t ∞; this setup generalizes the so‐called servomechanism problem of linear system theory.
Annual report shows value derived for QSL members (2013)

QSL is proud to deliver its 2012/13 Annual Report, which is now available at www.qsl.com.au. The report shows the value derived by QSL for members throughout the last financial year. A key highlight of this year's report is a performance snapshot of each of our value offerings (financing, pricing, marketing and logistics) including a historical five-year overview.