gebhart/patrepeval huggingface dataset:
Immune Monitoring Protocol for Patients with Carcinoma of the Head and Neck (1978)

Numerous investigators have observed a depression of cell-mediated immunity in patients with carcinoma of the head and neck using a variety of in vitro and in vivo assays. This report presents the data obtained when a group of head and neck cancer patients were evaluated for reactivity in an in vitro lymphocyte blastogenesis assay using polyclonal mitogens and specific antigens, numbers of peripheral blood T-lymphocytes, and levels of circulating immune complexes. Such an immunological monitoring protocol revealed a depressed reactivity of the cancer patients in the lymphocyte blastogenesis assay when compared to normal age-matched controls. We also observed that 75% of these patients had circulating soluble immune complexes in their sera before and after therapy. These preliminary data indicate that further research is needed to examine the potential role of soluble immune complexes in modulating the host's immune response.
Analysis of the medicinal properties of Callisia fragrans (2020)

<i>Callisia fragrans</i>, known colloquially as the basket plant, has been incorporated into traditional Vietnamese medicine to treat a variety of ailments, including cardiovascular disease, burns, and pre-gastric cancer. To elucidate its potential, this study was determined to isolate and analyze the efficacy of active compounds within the basket plant. A crude extract was derived
Mapping critical biological motifs and biosynthetic pathways of heparan sulfate (2004)

Heparan sulfate (HS) interacts with numerous proteins at the cell surface and orchestrates myriad biological events. Unraveling the mechanisms of these events at the molecular level calls for the structural analysis of these negatively charged and highly heterogeneous biopolymers. However, HS is often available only in small quantities, and the task of structural analysis necessitates the use of ultra-sensitive methods, such as mass spectrometry. Sequence heterogeneity within HS chains required us to identify critical functional groups and their spacing to determine structure-function relationships for HS. We carried out structural analysis of HS isolated from wild type, 3-OST-1, 3-OST-3A, or 3-OST-5 sulfotransferase-transduced Chinese hamster ovary cells and also from various tissues. In the context of tissue-specific HS, the data allowed us to map the biosynthetic pathways responsible for the placement of critical groups. As a means of determining the distance between critical groups within a motif, we determined the spacing of the rare GlcNAc-GlcA disaccharide sequence in the completely desulfated re-N-sulfated porcine intestinal heparin. These disaccharides are biosynthetic regulatory markers for 3-OST-1 modification and the partial structure of the antithrombin III binding site. They occur only at the distance of hexasaccharide, octasaccharide, decasaccharide, or dodecasaccharide. Thus this approach allowed us to map both the biosynthetic pathways for generating critical functional groups and their spacing within HS. Our new strategy removes two obstacles to rapid progress in this field of research.
Enumeration of Operations Performed for Elderly Patients in Ghana: An Opportunity to Improve Global Surgery Benchmarking (2019)

The operation rate was well beneath the benchmark, indicating a potentially large unmet need for Ghana's elderly population. Most operations for the elderly were in the essential category and delivered at district hospitals. Future global surgery benchmarking should consider specific benchmarks for different age groups.
Ion Motion in DiluteHe3-He4Solutions at Ultralow Temperatures (1972)

Measurements of the velocity of charge carriers in several dilute solutions of $^{3}\mathrm{He}$ in $^{4}\mathrm{He}$ in the temperature range 0.017-1.0 K are reported. The low-field negative-ion mobility shows a ${T}^{\ensuremath{-}\frac{1}{2}}$ dependence below 0.08 K characteristic of hard-sphere scattering. A maximum is observed in the mobility in the vicinity of 0.4 K. This can be interpreted in terms of a $^{3}\mathrm{He}$ condensation on the bubble surface. The positive-ion mobility is nearly temperature independent below 0.7 K. This has recently been interpreted in terms of a momentum-dependent polarization scattering. The field dependence of the positive-carrier velocity shows a discontinuity in the vortex-ring regime. The discontinuity can be shown to result from a size-dependent drag coefficient and a maximum is observed for very small rings (\ensuremath{\sim}16 \AA{}).
Abnormal Lesion Detection from Breast Thermal Images Using Chaos with Lyapunov Exponents (2013)

Breast cancer is the second most common cancer in women, and incidences of it continue to rise. The cure rate is increasing for breast cancer that is diagnosed in its early stages. That is why the value of breast health care is so important. Malignant breast tumor detection is extremely important for the physician. Generally, this task has been performed based on the experience and knowledge of the radiologists by analyzing the visual characteristics of the structures that appear in mammograms. The irregularity that exists in the edge of the typical cell that forms part of the tumor and tumoral structures (angiogenesis) is one of the major characteristics. Particularly, some malignant tumors involve a more irregular boundary edge, as compared to the benign ones. Speculating this feature by means of evaluating the irregularities can help support the diagnosis of malignancy. Hence, study of chaotic time series (CTS) can afford the tools necessary to generate the procedures to speculate the irregularities in the edges, through the use of the concept of fractal dimension (FD), which can produce the parameters to describe and categorize the structures under study. To detect the tumors and generate the time series (TS) characterizing the edge, techniques of digital image processing are applied over breast thermal images. Ahmed concluded that tumor growth, argued as a dynamical system, is chaotic. Proposed chaotic models fit the observations well. Some of these models treat the tumor as a fractal. In this chapter, Lyapunov exponents (LEs) are computed from CTS based on the Jacobian approach by using polynomial models. The chapter is organized as follows: the CTS is introduced in Section 9.2, the time-delay embedding (TDE) method is described in Section 9.3, followed by an explanation of LEs in 9.4. In Section 9.5, a method that is used to calculate the LEs is presented. The outline of the method to generate the TS of the edge is explained in Section 9.6, and Section 9.7 presents the results produced by using this process on the different types of tumors under study. Finally, the findings are concluded in Section 9.8.
Some raster graphics extensions to the Core System (1979)

The Core System is a proposed standard subroutine package for line-drawing graphics. We present some Core System extensions for use with raster graphics equipment. The extensions, which are upward-compatible with the present Core System, provide filled polygons, display of arrays of pixels, use of a color look-up table, and hidden-surface or hidden-edge removal. The extensions are being intergrated into an existing Core System implementation.
Reply to the Comment physics/0307134 by A. Helmstetter and D. Sornette (2003)

Reply to the Comment physics/0307134 by A. Helmstetter and D. Sornette
Partially purified Toxoplasma gondii antigens by immunoaffinity chromatography (1997)

Tachyzoite antigens of Toxoplasma gondii (RH) were partially purified by immunoaffinity chromatography. The cultivated Toxoplasma in vivo (mouse) and in vitro (Hep-2 cell) and peritoneal fluid of T. gondii infected mice were collected for antigen analysis. Tachyzoite antigens collected from infected mouse showed positive bands of 76 kDa, 70 kDa, 64 kDa, 53 kDa, 46 kDa, 44 kDa, 41 kDa, 35 kDa, 25 kDa, 18 kDa, and 13 kDa on immunoblot with anti-Toxoplasma rabbit sera, and those from infected Hep-2 cells revealed reactive bands of 70 kDa, 64 kDa, 53 kDa, 35 kDa 28 kDa, and 13-10 kDa. After applying to an IgG-Sepharose column, two elution peaks, E-1 and E-2 fractions, were obtained from both soluble antigen of T. gondii and the peritoneal fluid of infected mice, respectively. Immunoblots of soluble antigen with immunized rabbit sera revealed positive bands of 97 kDa, 63 kDa, 53 kDa, and 35 kDa from E-1 fraction and 53 kDa and 35 kDa from E-2. In the case of the eluted peaks from mice peritoneal fluid, E-1 showed protein bands of 84 kDa, 76 kDa, 53 kDa, and 29 kDa bands and 53 kDa and 45 kDa from E-2 on immunoblots. Serum IgG antibody titer of mice immunized with T. gondii tachyzoites was increased on 1 week after booster immunization when analysed by ELISA using crude antigen, while it was elevated on 3 weeks after booster immunization by ELISA using purified antigen.
Nonlinear Modelling and Control of PWM DC-DC Buck-Boost Converter for CCM (2018)

In this paper, a nonlinear model of inverting pulse-width-modulated buck-boost converter for continuous conduction mode is introduced based on the large-signal averaging technique. The simulation of the nonlinear buck-boost model is performed in MATLAB/SIMULINK and compared with the corresponding circuit in SaberRD simulator for validation purpose. Additionally, a nonlinear control scheme of cascaded proportional-integral sliding-mode current controller is designed. The equivalent control law, existence, and stability conditions are introduced. The simulation results show that the proposed control system enhances the regulation performance, removes the steady-state error, and provides robust tracking against large disturbances.
Carboxylated nanodiamonds inhibit γ-irradiation damage of human red blood cells (2016)

Nanodiamonds when carboxylated (cNDs) act as reducing agents and hence could limit oxidative damage in biological systems. Gamma (γ)-irradiation of whole blood or its components is required in immunocompetent patients to prevent transfusion-associated graft versus host disease (TA-GVHD). However, γ-irradiation of blood also deoxygenates red blood cells (RBCs) and induces oxidative damage, including abnormalities in cellular membranes and hemolysis. Using atomic force microscopy (AFM) and Raman spectroscopy, we examined the effect of cNDs on γ-irradiation mediated deoxygenation and morphological damage of RBCs. γ-Radiation induced several morphological phenotypes, including stomatocytes, codocytes and echinocytes. While stomatocytes and codocytes are reversibly damaged RBCs, echinocytes are irreversibly damaged. AFM images show significantly fewer echinocytes among cND-treated γ-irradiated RBCs. The Raman spectra of γ-irradiated RBCs had more oxygenated hemoglobin patterns when cND-treated, resembling those of normal, non-irradiated RBCs, compared to the non-cND-treated RBCs. cND inhibited hemoglobin deoxygenation and morphological damage, possibly by neutralizing the free radicals generated during γ-irradiation. Thus cNDs have the therapeutic potential to preserve the quality of stored blood following γ-irradiation.
Could Vagus Nerve Stimulation Target Hippocampal Hyperactivity to Improve Cognition in Schizophrenia? (2015)

OPINION article Front. Psychiatry, 24 March 2015Sec. Neuroimaging Volume 6 - 2015 | https://doi.org/10.3389/fpsyt.2015.00043
<p>Mechanism Investigation of Hyaluronidase-Combined Multistage Nanoparticles for Solid Tumor Penetration and Antitumor Effect</p> (2020)

Overall, our studies demonstrated that coating nanoparticles with HAase can provide a simple but efficient strategy for nano-drug carriers to enhance solid tumor penetration and chemotherapeutic efficacy.
Improvements in Turbulent Scalar Mixing Modeling for Trailing Edge Slot Film Cooling Geometries: A Combined Experimental and Computational Approach. (2015)

Abstract not provided.
Bronchoscopy-guided antimicrobial therapy for cystic fibrosis (2016)

This review, limited to a single, well designed randomized-controlled study, shows no clear evidence to support the routine use of bronchoalveolar lavage for the diagnosis and management of pulmonary infection in pre-school children with cystic fibrosis compared to the standard practice of providing treatment based on results of oropharyngeal culture and clinical symptoms. No evidence was available for adult and adolescent populations.
Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene mps1 (2004)

Aneuploidy, resulting from chromosome missegregation during meiosis, is a major cause of human infertility and birth defects. However, its molecular basis remains incompletely understood. Here we have identified a spectrum of chromosome anomalies in embryos of zebrafish homozygous for a hypomorphic mutation in Mps1, a kinase required for the mitotic checkpoint. These aneuploidies are caused by meiotic error and result in severe developmental defects. Our results reveal Mps1 as a critical regulator of chromosome number in zebrafish, and demonstrate how slight genetic perturbation of a mitotic checkpoint factor can dramatically reduce the fidelity of chromosome segregation during vertebrate meiosis.
OOP Response of THOR and Hybrid-III 50th% ATDs (2006)

&lt;div class="htmlview paragraph"&gt;The responses of the THOR and the Hybrid-III ATDs to head and neck loading due to a deploying air bag were investigated. Matched pair tests were conducted to compare the responses of the two ATDs under similar loading conditions. The two 50th percentile male ATDs, in the driver as well as the passenger positions, were placed close to the air bag systems, in order to enhance the interaction between the deploying air bag and the chin-neck-jaw regions of the ATDs. Although both ATDs nominally meet the same calibration corridors, they differ significantly in their kinematic and dynamic responses to interaction with a deploying air bag. The difference between the structural designs of the Hybrid-III's and the THOR's neck appears to result in significant differences in the manner in which the loads applied on the head are resisted.&lt;/div&gt;
E-cadherin phosphorylation by protein kinase D1/protein kinase C{mu} is associated with altered cellular aggregation and motility in prostate cancer. (2005)

The cadherin family of transmembrane glycoproteins plays a critical role in cell-to-cell adhesion and cadherin dysregulation is strongly associated with cancer metastasis and progression. In this study, we report a novel interaction between protein kinase D1 [PKD1; formerly known as protein kinase C mu (PKCmu)] and E-cadherin. PKD1 is a serine/threonine-specific kinase known to play a role in multiple cellular processes including apoptosis, cytoskeleton remodeling, and invasion. Our study shows that PKD1 colocalizes with E-cadherin at cell junctions in LNCaP prostate cancer cells and coimmunoprecipitates with E-cadherin from lysates of LNCaP cells. In vitro kinase assays have shown that PKD1 phosphorylates E-cadherin. Inhibition of PKD1 activity by the selective inhibitor Gö6976 in LNCaP cells resulted in decreased cellular aggregation and overexpression of PKD1 in C4-2 prostate cancer cells increased cellular aggregation and decreased cellular motility. We also validated the PKD1 and E-cadherin colocalization in human prostate cancer tissue by confocal laser scanning microscopy. Our study has identified E-cadherin as a novel substrate of PKD1, and phosphorylation of E-cadherin by PKD1 is associated with increased cellular aggregation and decreased cellular motility in prostate cancer. Because both E-cadherin and PKD1 are known to be dysregulated in prostate cancer, our study identified an important protein-protein interaction influencing the signal transduction system associated with cell adhesion in prostate cancer.
PAC$^m$-Bayes: Narrowing the Empirical Risk Gap in the Misspecified\n Bayesian Regime (2020)

The Bayesian posterior minimizes the "inferential risk" which itself bounds\nthe "predictive risk". This bound is tight when the likelihood and prior are\nwell-specified. However since misspecification induces a gap, the Bayesian\nposterior predictive distribution may have poor generalization performance.\nThis work develops a multi-sample loss (PAC$^m$) which can close the gap by\nspanning a trade-off between the two risks. The loss is computationally\nfavorable and offers PAC generalization guarantees. Empirical study\ndemonstrates improvement to the predictive distribution.\n
High-Level Folate Production in Fermented Foods by the B 12 Producer Lactobacillus reuteri JCM1112 (2008)

We observed that Lactobacillus reuteri JCM1112 produces B(12) and folate. However, the folate/B(12) mass ratio found was far below that desired for human consumption ( approximately 170:1). We used metabolic engineering applying genetic and physiological approaches to improve this ratio and developed a generic and natural process that significantly increases folate production.
Resource for the Development of Biomedical Accelerator Mass Spectrometry (AMS) (2017)

The NIH Research Resource for Biomedical AMS was originally funded at Lawrence Livermore National Laboratory in 1999 to develop and apply the technology of accelerator mass spectrometry (AMS) in broad- based biomedical research. The Resource’s niche is to fill needs for ultra high sensitivity quantitation when isotope-labeled agents are used. The Research Resource’s Technology Research and Development (TR&D) efforts will focus on the needs of the biomedical research community in the context of seven Driving Biomedical Projects (DBPs) that will drive the Center’s technical capabilities through three core TR&Ds. We will expand our present capabilities by developing a fully integrated HPLC AMS to increase our capabilities for metabolic measurements, we will develop methods to understand cellular processes and we will develop and validate methods for the application of AMS in human studies, which is a growing area of demand by collaborators and service users. In addition, we will continue to support new and ongoing collaborative and service projects that require the capabilities of the Resource. The Center will continue to train researchers in the use of the AMS capabilities being developed, and the results of all efforts will be widely disseminated to advance progress in biomedical research. Towards these goals, our specific aims are to:1.) Increase the value and information content of AMS measurements by combining molecular speciation with quantitation of defined macromolecular isolates. Specifically, develop and validate methods for macromolecule labeling, characterization and quantitation.2.) Develop and validate methods and strategies to enable AMS to become more broadly used in human studies. Specifically, demonstrate robust methods for conducting pharmacokinetic/pharmacodynamics studies in humans and model systems.3.) Increase the accessibility of AMS to the Biomedical research community and the throughput of AMS through direct coupling to separatory instruments.4.) Provide high throughput 14C BioAMS analysis for collaborative and service clients.
Table S1 from A Gene Expression Classifier from Whole Blood Distinguishes Benign from Malignant Lung Nodules Detected by Low-Dose CT (2023)

&lt;p&gt;Demographics for patients used in the microarray study&lt;/p&gt;
APPENDIX C The Nucleases of Escherichia coli (1993)

As an indication of the number of nucleases in a single organism, the tables list those nucleases that have been documented from Escherichia coli . These tables also serve as references for researchers looking for the paradigm of a number of enzyme homologs. One or two recent references are provided for each enzyme for an entree into the literature. Recent references can also be found in the other chapters of this book where the individual enzymes are discussed with regard to their function; older references can be found in the chapter on E. coli DNases or in the appendix on RNases in the first edition of Nucleases (S.M. Linn and R.J. Roberts; Cold Spring Harbor Laboratory [1982, 1985]). For additional references, see Bachmann’s 8th edition of the E. coli linkage map ( Microbiol. Rev. 54: 130 [1990]) or K. Rudd’s EcoBase. In the Deoxyribonucleases of E. coli table, molecular weights are based on the translated gene sequence where available, and map positions are according to Bachmann ( Microbiol. Rev. 54: 130 [1990]) for the 100-min E. coli linkage map. All known E. coli DNases that act as simple phosphodiesterases on undamaged DNA yield 3′-hydroxyl and 5′-phosphate termini, with the exception of Eco KI/ Eco BI which yield 3′-hydroxy and unknown 5′ termini. Included in the table for Ribonucleases of E. coli are RNases that have been reported to be present in E. coli , except for several that are now known to have been mixtures of enzymes or manifestations of other RNases. It is still possible that...
Transparent Offloading and Mapping (TOM): Enabling Programmer-Transparent Near-Data Processing in GPU Systems (2016)

Main memory bandwidth is a critical bottleneck for modern GPU systems due to limited off-chip pin bandwidth. 3D-stacked memory architectures provide a promising opportunity to significantly alleviate this bottleneck by directly connecting a logic layer to the DRAM layers with high bandwidth connections. Recent work has shown promising potential performance benefits from an architecture that connects multiple such 3D-stacked memories and offloads bandwidth-intensive computations to a GPU in each of the logic layers. An unsolved key challenge in such a system is how to enable computation offloading and data mapping to multiple 3D-stacked memories without burdening the programmer such that any application can transparently benefit from near-data processing capabilities in the logic layer. Our paper develops two new mechanisms to address this key challenge. First, a compiler-based technique that automatically identifies code to offload to a logic-layer GPU based on a simple cost-benefit analysis. Second, a software/hardware cooperative mechanism that predicts which memory pages will be accessed by offloaded code, and places those pages in the memory stack closest to the offloaded code, to minimize off-chip bandwidth consumption. We call the combination of these two programmer-transparent mechanisms TOM: Transparent Offloading and Mapping. Our extensive evaluations across a variety of modern memory-intensive GPU workloads show that, without requiring any program modification, TOM significantly improves performance (by 30% on average, and up to 76%) compared to a baseline GPU system that cannot offload computation to 3D-stacked memories.
Peiminine Inhibits Glioblastoma in Vitro and in Vivo Through Cell Cycle Arrest and Autophagic Flux Blocking (2018)

Peiminine inhibits glioblastoma in vitro and in vivo via arresting the cell cycle and blocking autophagic flux, suggesting new avenues for GBM therapy.
Bilinear discriminant analysis for face recognition (2008)

In this paper, a new statistical projection method called Bilinear Discriminant Analysis (BDA) is presented. The proposed method efficiently combines two complementary versions of Two-Dimensional-Oriented Linear Discriminant Analysis (2DoLDA), namely Column-Oriented Linear Discriminant Analysis (CoLDA) and Row-Oriented Linear Discriminant Analysis (RoLDA), through an iterative algorithm using a generalized bilinear projectionbased Fisher criterion. A series of experiments was performed on various international face image databases in order to evaluate and compare the effectiveness of BDA to RoLDA and CoLDA. The experimental results indicate that BDA is more efficient than RoLDA, CoLDA and 2DPCA for the task of face recognition, while leading to a significant dimensionality reduction. 1