gebhart/patrepeval huggingface dataset:
Erratum for Attarian et al., “The Monothiol Glutaredoxin Grx4 Regulates Iron Homeostasis and Virulence in Cryptococcus neoformans” (2019)

In Fig. 2B, we made a mistake in the assembly of the panels such that the images for the cells grown in LIM were used in both the panel labeled LIM and the panel labeled LIM ϩ 100 M heme.A new version of Fig. 2 has been prepared to show the correct images for the cells from the LIM ϩ 100 M heme condition.This mistake in figure preparation does not change any of the interpretations or conclusions in our paper.The Cir1-GFP fusion protein is located in the nucleus under all conditions.We apologize for any inconvenience.
Frequency domain model fitting and Volterra analysis implemented on top of harmonic balance simulation (2007)

The modern wireless communication techniques are aiming on increasing bandwidth and the number of carriers for higher data rate. This sets challenging linearity requirements for RF power amplifiers (PAs). Unfortunately, high linearity can only be obtained at the cost of efficiency. In order to improve the performance of the PA, in-depth understanding of nonlinear behaviour is mandatory. This calls for techniques that can give componentwise information of the causes of the distortion. The aim of this thesis is to develop a technique that can provide such information. This thesis proposes a detailed distortion analysis technique that is based on frequency domain fitting of polynomial models. Simulated large-signal spectra are used for fitting as these contain the necessary information about the large-signal bias point and amplitude range. Moreover, in the frequency domain the delays are easy to compensate, and detailed analysis to any fitted tone can be performed. The fitting procedure as such is simple but becomes difficult in multi-dimensional nonlinearities if the controlling voltages correlate strongly. In this thesis the solvability and reliability of the fitting procedure is increased by numerical operations, model-degree reduction and by using different excitations. A simplified Volterra method is used to calculate the distortion contributions by using the fitted model. The overall distortion is analysed by calculating the voltage response of the contributions of each nonlinearity to the terminal nodes of the device by the use of linear transfer functions of the circuit. The componentwise analysis is performed by phasor presentation enabling the cancelling mechanisms to be seen. The proposed technique is implemented on top of harmonic balance simulation in an APLAC circuit simulator in which extensive distortion simulations are performed. The technique relies on the existing device model and thus the fitted model can be only as accurate as the particular simulation model. However, two different RF PAs are analysed that show a good agreement between measurements and simulations. The proposed technique is verified with several test cases including amplitude dependent amplitude and phase distortion, intermodulation distortion sweet spots, bandwidth dependent memory effects and impedance optimization. The main finding of the detailed analysis is that the distortion is a result of several cancelling mechanisms. In general, cubic nonlinearity of transconductance is dominating the in-band distortion but is cancelled by the 2nd-degree nonlinearity that is mixed to the fundamental band from envelope and 2nd harmonic bands that is usually the main cause of memory effects.
Suramin, an Active Drug for Prostate Cancer: Interim Observations in a Phase I Trial (1993)

Future trials should address the role and necessary extent of therapeutic drug monitoring; the optimal plasma drug concentration range and duration of therapy; and the activity of suramin in combination with other agents, in earlier stages of prostate cancer, and in other tumor types.
Cycloalkanones. 2. Synthesis and biological activity of .alpha.,.alpha.'-dibenzylcycloalkanones (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCycloalkanones. 2. Synthesis and biological activity of .alpha.,.alpha.'-dibenzylcycloalkanonesClaude Piantadosi, Iris H. Hall, John L. Irvine, and Gerald L. CarlsonCite this: J. Med. Chem. 1973, 16, 7, 770–775Publication Date (Print):July 1, 1973Publication History Published online1 May 2002Published inissue 1 July 1973https://pubs.acs.org/doi/10.1021/jm00265a006https://doi.org/10.1021/jm00265a006research-articleACS PublicationsRequest reuse permissionsArticle Views177Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Low-Affinity Ca2+-Dependent Association of Calmodulin With the Rab3A Effector Domain Inversely Correlates With Insulin Exocytosis (2001)

The stimulus-response coupling pathway for glucose-regulated insulin secretion has implicated a rise in cytosolic [Ca2+]i as a key factor to induce insulin exocytosis. However, it is unclear how elevated [Ca2+]i communicates with the pancreatic beta-cell's exocytotic apparatus. As Rab3A is a model protein involved in regulated exocytosis, we have focused on its role in regulating insulin exocytosis. By using a photoactivatable cross-linking synthetic peptide that mimics the effector domain of Rab3A and microsequence analysis, we found calmodulin to be a major Rab3A target effector protein in pancreatic beta-cells. Coimmunoprecipitation analysis from pancreatic islets confirmed a Rab3A-calmodulin interaction in vivo, and that it inversely correlated with insulin exocytosis. Calmodulin affected neither GTPase nor guanine nucleotide exchange activity of Rab3A. The calmodulin-Rab3A interaction was pH- and Ca2+-dependent, and it was preferential for GTP-bound Rab3A. However, Rab3A affinity for calmodulin was relatively low (Kd = 18-22 micromol/l at 10(-5) mol/l [Ca2+]) and competed by other calmodulin-binding proteins that had higher affinity (e.g., Ca2+/calmodulin-dependent protein kinase-2 [CaMK-2] [Kd = 300-400 nmol/l at 10(-5) mol/l [Ca2+]]). Moreover, the Ca2+ dependence of the calmodulin-Rab3A interaction (K0.5 = 15-18 micromol/l [Ca2+], maximal at 100 micromol/l [Ca2+]) was significantly lower compared with that of the calmodulin-CaMK-2 association (K0.5 = 40 micromol/l [Ca2+], maximal at 1 mmol/l [Ca2+]). The data suggested that a transient Rab3A-calmodulin interaction might represent a means of directing calmodulin to the cytoplasmic face of a beta-granule, where it can be subsequently transferred for activation of other beta-granule-associated calmodulin-binding proteins as local [Ca2+]i rises to promote insulin exocytosis.
The Case for an Interwoven Parallel Hardware/Software Stack (2021)

The layered structure of the system software stacks we use today allows for separation of concerns and increases portability. However, the confluence of widely available virtualization and hardware partitioning technology, new OS techniques, rapidly changing hardware, and significant advances in compiler technology together present a ripe opportunity for restructuring the stack, particularly to support effective parallel execution. We argue that there are cases where layers, particularly the compiler, run-time, kernel, and hardware, should be interwoven, enabling new optimizations and abstractions. We present four examples where we have successfully applied this interweaving model of system design, and we outline several lines of promising ongoing work.
Compressed Sensing Based Protocol for Interfering Data Recovery in Multi-Hop Sensor Networks (2014)

We consider a multi-hop wireless sensor network that measures sparse events and propose a novel protocol based on Compressed Sensing (CS) as an alternative to traditional Media Access Control (MAC) scheduling and routing protocol. Instead of avoiding collisions, our CS-based protocol exploits interferences by superimposing the data measurements "over-the-air", simultaneously received at any node. Thanks to our protocol design, each node is able to recover and forward only new data towards the sink. Our protocol achieves near zero reconstruction errors at the sink, while greatly reducing overhead and delays compared to conventional methods. These results reveal a new and promising approach to protocol design through CS.
Stability of a Jet in Confined Pressure-Driven Biphasic Flows at Low Reynolds Numbers (2007)

Motivated by its importance for microfluidic applications, we study the stability of jets formed by pressure-driven concentric biphasic flows in cylindrical capillaries. The specificity of this variant of the classical Rayleigh-Plateau instability is the role of the geometry which imposes confinement and Poiseuille flow profiles. We experimentally evidence a transition between situations where the flow takes the form of a jet and regimes where drops are produced. We describe this as the transition from convective to absolute instability, within a simple linear analysis using lubrication theory for flows at low Reynolds number, and reach remarkable agreement with the data.
The dataflow pointcut (2009)

Some security concerns are sensitive to flow of information in a program execution. The dataflow pointcut has been proposed by Masuhara and Kawauchi in order to easily implement such security concerns in aspect-oriented programming (AOP) languages. The pointcut identifies join points based on the origins of values. This paper presents a formal framework for this pointcut based on the λ_calculus. Dataflow tags are propagated statically to track data dependencies between expressions. We introduce a static semantics for tag propagation and prove that it is consistent with respect to the dynamic semantics of the propagation. We instrument the static effect-based type system to propagate tags, match and inject advices. This static approach can be used to minimize the cost of dataflow pointcuts by reducing the runtime overhead since much of the dataflow information would be available statically and at the same time it can be used for verification. The proposed semantics for advice weaving is in the spirit of AspectJ where advices are injected before, after, or around the join points that are matched by their respective pointcuts. Inspired from the formal framework, the AspectJ compiler ajc is extended with the dataflow pointcut that tracks data dependencies inside methods.
Persistence Patterns of Porphyromonas gingivalis, Prevotella intermedia/ nigrescens, and Actinobacillus actinomycetemcomitans After Mechanical Therapy of Periodontal Disease (2000)

If, after standard mechanical periodontal therapy, a large number of sites continue to bleed, one may expect an increased number of sites positive for P. intermedia/ nigrescens. If many deep pockets persist, a greater number of P. gingivalis-positive sites can be expected.
The effects of a prostaglandin synthetase inhibitor, ibuprofen, on the cardiopulmonary response to endotoxin in sheep. (1982)

Prostaglandins released during inflammatory reactions cause increases in microvascular hydrostatic pressure, a primary cause of edema. Ibuprofen, a nonsteroidal, anti-inflammatory agent that reduces prostaglandin synthesis via inhibition of cyclooxygenase, was used to investigate the possible role of prostaglandins in the cardiopulmonary responses during sepsis. Sheep, surgically prepared for cardiopulmonary studies and collection of lung lymph, were given 0.75 micrograms/kg per 30 min of E. coli endotoxin iv. Ibuprofen (14 mg/kg) was given 15 min before and 1 h 45 min after the administration of endotoxin. We had previously noted a triphasic character to the hypovolemia encountered in endotoxin sepsis. The initial phase occurs during the first hour after endotoxin administration; it is characterized by decreases in PaO2, neutrophil count, and lymph-to-plasma (L/P) protein concentration ratios and by increases in mean arterial pressure, body temperature, hematocrit, lymph flow, and total plasma protein concentration. In the second phase these variables return toward their baseline values. In Phase 3 the same changes are observed an in Phase 1 except for a decrease in total plasma protein concentration and an increase in L/P ratios. Ibuprofen administration results in a statistically significant reduction in magnitude of Phase 1 changes, without notable effect on Phase 2 or Phase 3 values. These observations support the hypothesis that prostaglandins released during inflammatory reactions contribute to the extravascular fluid movement. Ibuprofen appears to lessen the severity of microvascular hydrostatic pressure-induced edema and the hypovolemia that occurs in the early stages of endotoxin.
An International Perspective on Chronic Multimorbidity: Approaching the Elephant in the Room (2017)

Multimorbidity is a common and burdensome condition that may affect quality of life, increase medical needs, and make people live more years of life with disability. Negative outcomes related to multimorbidity occur beyond what we would expect from the summed effect of single conditions, as chronic diseases interact with each other, mutually enhancing their negative effects, and eventually leading to new clinical phenotypes. Moreover, multimorbidity mirrors an accelerated global susceptibility and a loss of resilience, which are both hallmarks of aging. Due to the complexity of its assessment and definition, and the lack of clear evidence steering its management, multimorbidity represents one of the main current challenges for clinicians, researchers, and policymakers. The authors of this article recently reflected on these issues during two twin international symposia at the 2016 European Union Geriatric Medicine Society (EUGMS) meeting in Lisbon, Portugal, and the 2016 Gerontological Society of America (GSA) meeting in New Orleans, USA. The present work summarizes the most relevant aspects related to multimorbidity, with the ultimate goal to identify knowledge gaps and suggest future directions to approach this condition.
Pain Facilitation Brain Regions Activated by Nalbuphine Are Revealed by Pharmacological fMRI (2013)

Nalbuphine, an agonist-antagonist kappa-opioid, produces brief analgesia followed by enhanced pain/hyperalgesia in male postsurgical patients. However, it produces profound analgesia without pain enhancement when co-administration with low dose naloxone. To examine the effect of nalbuphine or nalbuphine plus naloxone on activity in brain regions that may explain these differences, we employed pharmacological magnetic resonance imaging (phMRI) in a double blind cross-over study with 13 healthy male volunteers. In separate imaging sessions subjects were administered nalbuphine (5 mg/70 kg) preceded by either saline (Sal-Nalb) or naloxone 0.4 mg (Nalox-Nalb). Blood oxygen level-dependent (BOLD) activation maps followed by contrast and connectivity analyses revealed marked differences. Sal-Nalb produced significantly increased activity in 60 brain regions and decreased activity in 9; in contrast, Nalox-Nalb activated only 14 regions and deactivated only 3. Nalbuphine, like morphine in a previous study, attenuated activity in the inferior orbital cortex, and, like noxious stimulation, increased activity in temporal cortex, insula, pulvinar, caudate, and pons. Co-administration/pretreatment of naloxone selectively blocked activity in pulvinar, pons and posterior insula. Nalbuphine induced functional connectivity between caudate and regions in the frontal, occipital, temporal, insular, middle cingulate cortices, and putamen; naloxone co-admistration reduced all connectivity to non-significant levels, and, like phMRI measures of morphine, increased activation in other areas (e.g., putamen). Naloxone pretreatment to nalbuphine produced changes in brain activity possess characteristics of both analgesia and algesia; naloxone selectively blocks activity in areas associated with algesia. Given these findings, we suggest that nalbuphine interacts with a pain salience system, which can modulate perceived pain intensity.
Shape Evaluation Method for Leading and Trailing Edges of Aero-engine Blade (2022)

Abstract The shape of the leading and trailng edges of aero-engine blades has a significant influence on its aerodynamic performance. At present, the method of manual inspection based on the standard pattern is mainly used to analyze the shape of the leading, and trailing edges, which has the problems of low efficiency, poor repeatability and inconsistent evaluation results. An automatic shape evaluation method based on eigenvalues is proposed in this paper. Firstly, the blade profile and its mean camber line are segmented and fitted. Then, evaluation indexes are given for the five unqualified edge shapes respectively according to the curvature characteristics and profile variation characteristics. Finally, the shape of the blade edge is evaluated with the eigenvalues calculated. Experiments show that the proposed method can realize the automatic shape evaluation of blade leading and trailng edges, and can adapt to different types of blades and different acceptance standards, which effectively improves the efficiency of blade profile quality inspection.
<p>Current approaches in the grading and management of cytokine release syndrome after chimeric antigen receptor T-cell therapy</p> (2019)

With immunotherapy innovations for cancer treatment, in particular chimeric antigen receptor (CAR) T cells, becoming more successful and prevalent, strategies to mitigate and manage their toxicities are required. Anti-CD19 CAR T-cell therapy has revolutionized the treatment of relapsed/refractory pediatric and adult acute lymphoblastic leukemia and refractory adult non-Hodgkin lymphoma, resulting in the expanded use of CAR T cells in multicenter trials and as US FDA-approved products. Cytokine release syndrome (CRS) and CAR-associated neurotoxicity, which can occur independently or concurrently with CRS, are two potentially life-threatening toxicities of CAR T-cell therapy. In this review, we will focus on describing the pathophysiology behind CRS, the proposed definitions of and grading systems for CRS, and innovative options for treating this potentially lethal systemic inflammatory condition.
A VLA Search for the Geminga Pulsar at 74 and 326 MHz (2000)

Abstract We have used the VLA to image the location of the gamma-ray pulsar Geminga at 74 and 326 MHz. Upper limits to the pulse-averaged flux density, taking diffractive scintillation (DISS) into account, are S &lt; 56 mJy (2 σ ; DISS quenched) at 74 MHz and S &lt; 5 mJy (95% confidence) at 326 MHz. Intrinsic variability appears to be required in order to reconcile our upper limits with previous low-frequency detections.
MICROWAVE STUDIES OF ARGON COMPLEXES WITH FULMINIC ACID AND ISOCYANIC ACID (1994)

Author Institution: Molecular Physics Division, National Institute of Standard and Technology
Photoreduction and Removal of Cadmium Ions over Bentonite Clay-Supported Zinc Oxide Microcubes in an Aqueous Solution (2020)

Cadmium ion is toxic to organisms and shows persistence because of its nondegradability. Photoreduction of the cadmium ion (Cd(II)) was studied using a bentonite-supported Zn oxide (ZnO/BT) photocatalyst in an aqueous medium under ultraviolet light. The prepared ZnO/BT photocatalyst was characterized by diffuse reflectance spectroscopy, field-emission scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, photoluminescence spectroscopy, transmission electron microscopy, energy-dispersive spectroscopy, and Brunauer-Emmett-Teller/Barrett-Joyner-Halenda analysis. The effects of main parameters including pH, contact time, initial concentration of cadmium(II) ion, light intensity, temperature, and the photocatalyst dosage were investigated for obtaining appreciate reduction/removal efficiency. The maximum reduction/removal efficiency of 74.8% was obtained at optimized values which were found to be at pH 5, 6 h contact time, 6 ppm Cd(II) ion, 200 W UV light, 45 °C temperature, and 4 g/L of ZnO/BT. Reduction/removal of Cd(II) was significantly affected by light intensity so that the increment in UV intensity from 0 to 200 increased the reduction/removal efficiency from 61.2 to 76.8%. This study reports an inexpensive and environmentally friendly photocatalyst for Cd<sup>2+</sup> reduction in real samples and prospective photoelectric materials.
Mango fruit on tree image collection (2017)

This collection of images of mango trees with fruit at stone hardening stage under artificial illumination have been used in a series of machine vision exercises, working towards an automated estimated of crop load. The images have been collected from different areas on one farm, from different seasons and from different farms/growing areas. Thus a set of images can be used in calibration of a machine vision approach, leaving independent sets for validation. The image sets have been used for this purpose, with work documented in three publications (noted elsewhere). It is anticipated that other researchers in the machine vision - crop load assessment area might use the images, benchmarking against results achieved to date.
Preliminary Safety Analysis of a Wearable Clinic for the Early Detection of Psychotic Relapse (2020)

We discuss the preliminary safety analysis of a smartphone-based intervention for early detection of psychotic relapse. We briefly describe how we identified patient safety hazards associated with the system and how measures were defined to mitigate these hazards.