gebhart/patrepeval huggingface dataset:
Orthogonal linear polarization detection slot-ring antenna (2012)

The emerging planar array antenna technology covers a wide range of applications such as point to point and point to multi point wireless communication systems, radar systems, remote sensing, GPS, ITS etc. [1–6]. The polarization detection of the received signal for many applications such as polarimetric sensors, MIMO, satellite remote sensing, ITS, radars etc. is becoming important in recent years. In a word, if the detection of the polarization characteristics and the wireless propagation conditions of the received signals are possible, the above application modules and systems will be advanced and expanded much more effectively. For instance, polarization detection antenna can be a vital element for the realization of the anti-jamming technology of radar systems [3]. To meet this requirement, the authors have reported an orthogonally polarized microstrip array antenna for linear polarization discrimination [7], where ±45 deg. linear polarizations of the received signal can be discriminated at the array antenna design frequency. The array antenna was realized by 12 patch antenna elements and a double balanced RF multiplier. However, there was an impedance mismatch between the antenna elements and the feed lines. As a result, the output voltage for the polarization detection was low in spite of the 12 elements array antenna.
PP.11.15 (2015)

Objective: Maternal obesity in rodents leads to sympathetic mediated hypertension in the juvenile offspring prior to obesity. This is associated with an exaggerated leptin surge in early postnatal life. The aim of this study was to determine the impact of this exaggerated neonatal leptin surge on the long-term renal structure and function, independent of the presence of hypertension, using a normotensive melanocortin-4 receptor deficient (MC4R -/-) mice model. Design and method: Neonatal mice were treated with leptin (L-Tx; 3 mg/kg IP) or saline (S-Tx), postnatal day 9–14. Mean arterial pressure (MAP) and glomerular filtration rate (GFR) were measured at 6 month old wild-type (WT) and MC4R (-/-) mice using radiotelemetry and creatinine clearance test respectively. After hypertension had been established in WT, markers of renal injury, intrarenal renin-angiotensin system and sodium transporters were assessed and compared with normotensive MC4R (-/-) mice. Results: At 6 months of age, obese MC4R (-/-) mice were hyperphagic and hyperleptinaemic compared with WT. Neonatal leptin (L-Tx) induced body weight, food intake and fat mass in WT with no influence in the MC4R (-/-) mice. L-Tx-WT mice showed also 30% less glomerular area and reduced creatinine clearance [GFR, ml/min gKW, L-Tx, 0.46 ± 0.06 vs. S-Tx, 1.34 ± 0.32, n = 6, p < 0.01] with no additive effect in the MC4R (-/-) mice. Renal injury was increased in L-Tx mice with higher urinary albumin excretion (UAE) and ratio UAE/creatinine in MC4R (-/-) compared with WT. The L-Tx WT mice showed greater expression of renal tyrosine hydroxylase (TH), angiotensin II receptor (AT1a) and renin with marked down-regulated angiotensin II 2 (AT2R). These alterations were associated with elevated proximal tubule Na-H exchanger 3 transporter. Interestingly L-Tx mice also demonstrated increased renal NADPH oxidase 4 (NOX-4) and cyclooxygenase 2 (COX-2) expression [COX-2, L-Tx, 458 ± 92 vs. S-Tx, 162 ± 37, n = 6, p < 0.01]. COX has been associated with angiotensin II induced hypertension and reactive oxygen species (ROS). Conclusions: Thus, alterations in MAP, Ang II pathways and ROS handling in the kidney, may reset the tubular functions in neonatal leptin mice and underpin the development of hypertension and renal dysfunction.
Effect of Substitution on the Hysteretic Phase Transition in a Bistable Phenalenyl‐Based Neutral Radical Molecular Conductor (2018)

The ability to tune the physical properties of bistable organic functional materials by means of chemistry can facilitate their development for molecular electronic switching components. The butylamine-containing biphenalenyl boron neutral radical, [Bu]<sub>2</sub> B, crystalline compound has recently attracted significant attention by displaying a hysteretic phase transition accompanied by simultaneous bistability in magnetic, electrical, and optical properties close to room temperature. In this report, substitutional doping was applied to [Bu]<sub>2</sub> B by crystallizing solid solutions of bistable [Bu]<sub>2</sub> B and its non-radical-containing counterpart [Bu]<sub>2</sub> Be. With increasing doping degree, the hysteretic phase transition is gradually suppressed in terms of reducing the height, but conserves the width of the hysteresis loop as observed through magnetic susceptibility and electrical conductivity measurements. At the critical doping level of about 6 %, the abrupt transformation of the crystal structure to that of the pure [Bu]<sub>2</sub> Be crystal packing was observed, accompanied by a complete collapse of the hysteresis loop. Further study of the structure-properties relationships of bistable neutral radical conductors based on the [Bu]<sub>2</sub> B host can be conducted utilizing a variety of biphenalenyl-based molecular conductors.
The Nanobody JK36 circumvents the epitope overlapping commonly observed between therapeutic anti-CD38 antibodies and commercially available analytical mouse antibodies (2021)

Abstract Therapeutic anti-CD38 antibodies have been demonstrated to elicit immune-mediated elimination of plasma cells and other CD38-expressing cells. Epitope overlapping with commercially available analytical monoclonal mouse anti-CD38 antibodies limits the possibility to study surface CD38 expression in the presence of these therapeutic antibodies. Nanobodies, derived from heavy-chain antibodies that naturally occur in llamas and other Camelids, can circumvent these undesired interferences. Nanobodies are single variable domain antibody fragments (VHH) that often expose a long complementarity-determining region 3 (CDR3). This feature allows them to recognize hidden epitopes, e.g. in molecular cavities, that are inaccessible to the CDRs in conventional analytical and therapeutic antibodies. In a model of anti-CD38 occupation with a therapeutic antibody, we have evaluated JK36, an anti-CD38 nanobody recognizing a cryptic epitope. Normal whole blood samples were pre-incubated with Daratumumab, a therapeutic humanized anti-CD38 mouse antibody. Binding of the Rabbit-JK36 (Rb-JK36) construct was compared to the binding observed with the conventional mouse antibodies, clones LS198-4-3 and T16. LS198-4-3 and T16 antibodies partially or completely failed to label the CD38 epitope, in case of being masked with Daratumumab. In contrast, the Rb-JK36 staining pattern and intensity remained unchanged, confirming that Rb-JK36 binds to an epitope which is not masked by Daratumumab. This study confirms that JK36 is a well-suited probe for research studies on CD38 expression in the presence of therapeutic or commonly used analytical anti-CD38 antibodies, opening new methodical approaches in plasma cell immunotherapy research.
Oncogenic Function and Early Detection Potential of miRNA-10b in Oral Cancer as Identified by microRNA Profiling (2012)

The miRNA participates in a variety of biologic processes, and dysregulation of miRNA is associated with malignant transformation. In this study, we determined specific profile of miRNA associated with oral cancer by using miRNA array screening method. There were 23 miRNAs found with considerably differential expressions between six oral cancer cell lines and five lines of normal oral keratinocytes, in which, 10 miRNAs showed the highest significant difference after independent examination by reverse transcription quantitative PCR. Eight molecules were upregulated, miR-10b, miR-196a, miR-196b, miR-582-5p, miR-15b, miR-301, miR-148b, and miR-128a, and two molecules, miR-503 and miR-31, were downregulated. The most upregulated miR-10b was further examined, and its functions were characterized in two oral cancer cell lines. The miR-10b actively promotes cell migration (2.6- to 3.6-fold) and invasion (1.7- to 1.9-fold) but has minimal effect on cell growth or chemo-/radiosensitivity. Furthermore, miR-10b was considerably elevated in the plasma of xenografted tumor mice (20-fold). This upregulation of miR-10b in plasma was further shown in the patients with oral cancer [P < 0.0001, area under curve (AUC) = 0.932] and precancer lesions (P < 0.0001, AUC = 0.967), suggesting that miR-10b possesses a high potential to discriminate the normal subjects. In conclusion, we have identified at least 10 miRNAs significantly associated with oral cancer, including the most elevated miR-10b. The miR-10b actively participates in cancer formation by promoting cell migration and invasion. Our study using clinical samples suggests that plasma miR-10b has high potential as an early detection marker for oral cancer.
Close Contact: An Examination Of The Future Of Near Field Communications (2011)

Payment systems are changing and credit cards might soon be obsolete. Near field communications systems are being built into many smartphones which will enable users to not only pay for goods and services but to obtain information from NFC-enables products. Some emerging technologies are examined and potential security concerns are outlined.
Improved Color Rendition in High Pressure Mercury Vapor Lamps (1977)

AbstractThe addition of Y3Al5O12: Ce to the group of phosphors suitable for color correcting the mercury discharge lamp provides for improving the color rendering index without a lumen loss. By altering the cerium content in the formulation, the absorption and brightness can be adjusted to its optimum value in the lamp.
Ruthenium Carbene-Based Olefin Metathesis Initiators:  Catalyst Decomposition and Longevity (1999)

Thermolytic decomposition pathways were studied for several ruthenium carbene-based olefin metathesis catalysts. Substituted carbenes were found to decompose through bimolecular pathways while the unsubstituted carbene was found to decomposed unimolecularly. Implications for ring-closing metathesis are discussed, and the longevity of several ruthenium-based catalysts are compared.
The Need for an Executive Leadership Curriculum in Scientist-Clinician Training Programs (2018)

The health of Canadians depends on effective leadership among health care providers to facilitate the translation of new health discoveries into clinical practice. Clinician-scientists play an important role in bridging the gap between research and clinical practice, and require effective leadership skills to advance clinical practice successfully. To accelerate the leadership development in clinician scientist trainees, with the aim of developing strong leaders in administration and health advocacy, the Leaders in Medicine (LIM) training program at the University of Calgary created an Executive Leadership Coaching Program involving three phases: 1) an evidence-based evaluation tool, the Core Values IndexTM (CVI), that was used to identify the key drivers behind how individuals can be most effective in making their contribution; 2) small group workshops to debrief the results of the CVI assessment; and 3) one-on-one executive coaching sessions to facilitate the discovery, development and deployment of individual leadership capabilities. Coaching in leadership strategies enables clinician-scientist trainees to lead, influence, manage and deliver science-based improvements into the practice of medicine. We strongly recommend that other Canadian scientist-clinician training programs consider opportunities like the ones we offer to our LIM trainees. This training has important implications for the delivery of healthcare in Canada.
A Magnetosome-specific GTPase from the Magnetic BacteriumMagnetospirillum magneticum AMB-1 (2001)

Magnetic bacteria produce intracellular vesicles that envelope single domain magnetite crystals. Although many proteins are present in this intracellular vesicle membrane, five are specific to this membrane. A 16-kDa protein, designated Mms16, is the most abundant of the magnetosome-specific proteins, and to establish its function we cloned and sequenced its gene from Magnetospirillum magneticum AMB-1. This was achieved by determination of the N-terminal amino acid sequence of the protein following two dimensional polyacrylamide gel electrophoresis, and sequencing of the gene was performed by gene walking using anchored polymerase chain reaction. Mms16 contains a putative ATP/GTP binding motif (P-loop). Recombinant Mms16 with a hemagglutinin tag, was expressed in Escherichia coli and purified. Recombinant Mms16 protein could bind GTP and showed GTPase activity. GTP was the preferred substrate for Mms16-catalyzed nucleotide triphosphate hydrolysis. These results suggest that a novel protein specifically localized on the magnetic particle membrane, Mms16, is a GTPase. Mms16 protein showed similar characteristics to small GTPases involved in the formation of intracellular vesicles. Furthermore, addition of the GTPase inhibitor AlF(4)- also inhibited magnetic particle synthesis, suggesting that GTPase is required for magnetic particles synthesis.
Fermi surface interconnectivity and topology in Weyl fermion semimetals TaAs, TaP, NbAs, and NbP (2015)

The family of binary compounds including TaAs, TaP, NbAs, and NbP was recently discovered as the first realization of Weyl semimetals. In order to develop a comprehensive description of the charge carriers in these Weyl semimetals, we performed detailed and systematic electronic band structure calculations which reveal the nature of Fermi surfaces and their complex interconnectivity in TaAs, TaP, NbAs, and NbP. Our work reports a comparative and comprehensive study of Fermi surface topology and band structure details of all known members of the Weyl semimetal family and hence provides the fundamental knowledge for realizing the many predicted exotic topological quantum physics of Weyl semimetals based on the TaAs class of materials.
Rule-based model transformation for, and in simulink (2014)

Over the past decade, the design of embedded systems has come to rely on models as electronic artifacts that are both analysable and executable. Such executable models are at the core of Model-Based Design. Simulink® is a popular Model-Based Design tool that supports simulation of models in various stages of design. While Simulink supports relating the various different models used in design, the technology to do so relies on the underlying Simulink code base. Instead, this paper employs explicit models of the relations between the various different design models. In particular, a rule-based approach is presented for model-to-model transformations. The abstraction from the code base provides benefits such as a more intuitive representation and the ability to more effectively reason about the transformations. The transformation rules and schedules are designed by augmenting standard Simulink model elements (e.g., blocks) for use in model transformation based on the structured RAMification approach. The approach is illustrated by the transformation of a continuous-time model, part of an adaptive controller, to a disrete-time counterpart, which is consecutively optimized for simulation.
Purely geometrical coarse wavelength multiplexer/demultiplexer (2003)

A planar waveguide device is proposed and analysed that enables wavelength multiplexing and demultiplexing between the 1300 and 1550 nm telecommunications windows, based solely on the evolution of the fundamental mode through the geometrical design of the device. No coupling, grating or interference effects are required for its operation.
Strategies for Pre-training Graph Neural Networks (2019)

Many applications of machine learning require a model to make accurate pre-dictions on test examples that are distributionally different from training ones, while task-specific labels are scarce during training. An effective approach to this challenge is to pre-train a model on related tasks where data is abundant, and then fine-tune it on a downstream task of interest. While pre-training has been effective in many language and vision domains, it remains an open question how to effectively use pre-training on graph datasets. In this paper, we develop a new strategy and self-supervised methods for pre-training Graph Neural Networks (GNNs). The key to the success of our strategy is to pre-train an expressive GNN at the level of individual nodes as well as entire graphs so that the GNN can learn useful local and global representations simultaneously. We systematically study pre-training on multiple graph classification datasets. We find that naive strategies, which pre-train GNNs at the level of either entire graphs or individual nodes, give limited improvement and can even lead to negative transfer on many downstream tasks. In contrast, our strategy avoids negative transfer and improves generalization significantly across downstream tasks, leading up to 9.4% absolute improvements in ROC-AUC over non-pre-trained models and achieving state-of-the-art performance for molecular property prediction and protein function prediction.
Biological and Structural Studies with an Adenovirus Type 2 Temperature-Sensitive Mutant Defective for Uncoating (1983)

We compared some of the biological and structural features of an adenovirus type 2 temperature-sensitive mutant (ts1) defective for maturation cleavages and uncoating with wild-type (WT) virus. The cleavage defect caused ts1 to produce virions at 39 degrees that contained five precursor proteins (pTP, 11K, PVI, PVII, PVIII). Coinfection of cells with such ts1 virions and a variety of mutants or WT virus not only failed to complement ts1 but actually depressed the infection by the second virus. The uncoating defect could only be overcome by multiplicity-dependent leakiness. The structure of the ts1 virion was compared with that of WT virus by iodination with chloramine-T, chloroglycoluril and lactoperoxidase, by cross-linking, and by digestion with proteases. Aside from the presence of precursor proteins and the greater stability of ts1 virions, no other differences were found that could account for the uncoating defect. Therefore, we postulate that this defect was caused by the greater stability imparted to the virion by precursor proteins PVI, PVII and PVIII.
Electrochemical characteristics of Si/Mo multilayer anode for Li ion batteries (2007)

"We have prepared the Si/Mo multilayer by alternate deposition with a multi-gun rf/dc magnetron sputtering system. A current collector wasCu foil that had a rough surface. Pre-treatment with plasma on the surface was performed in order to improve adhesion between an electrodeand substrate and to remove contamination on the surface. The structural and electrochemical characteristics of yhe Si/Mo multilayer wereinvestigated. The initial capacity of the Si thin film rapidly degraded after 40 cycles, whereas the multilayer maintained more than 90 % ofthe initial capacity (2653 mAhg¡1) after 100 cycles."
Autolysis of thermophilic lactobacilli and dairy propionibacteria: A review (1997)

International audience
A Strong Antifungal-producing Bacteria from Bamboo Powder for Biocontrol of Sclerotium rolfsii in Melon (Cucumis melo var. amanta) (2016)

Bamboo (Bambusa edulis Munro) rhizosphere has been known for its potency to reduce plant pathogen because it contains diverse beneficial microbes, thus bamboo plant itself might be a potential source for bio-control agent discovery. Sclerotium rot, caused by Sclerotium rolfsii Sacc, is one of the most devastating non-specific diseases of plant, including melon (Cucumis melo var. amanta). The aim of this study was to screen and characterise novel bacteria isolates from bamboo powder that have beneficial application for crop protection. Bacillus subtilis BMB26 produced an extracellular metabolite that effective against a wide range of pathogenic fungi, including S. rolfsii, and resistant to heat and protease. Furthermore, to evaluate the application of cell-free filtrates BMB26 on melon plants, a cotyledon test was done under greenhouse condition. A significant decrease was observed in disease incidence (up to 77%) occurred in BMB26-treated melon leaves inoculated with S. rolfsii after 4 days post-inoculation. This result showed that Bacillus subtilis BMB26 has a potential application as a bio-control agent against phytopathogenic fungi.
A phase III study of futibatinib (TAS-120) versus gemcitabine-cisplatin (gem-cis) chemotherapy as first-line (1L) treatment for patients (pts) with advanced (adv) cholangiocarcinoma (CCA) harboring fibroblast growth factor receptor 2 (FGFR2) gene rearrangements (FOENIX-CCA3). (2020)

TPS600 Background: Pts with adv CCA have poor survival outcomes, and chemotherapy offers limited survival benefit (5-year survival rates, 5–10%; median overall survival [OS], 8–12 months). FGFR2 gene rearrangements are known to be early drivers of oncogenesis in ~15% of pts with intrahepatic (i) CCA. Futibatinib, an oral, highly selective, irreversible FGFR1-4 inhibitor has shown antitumor activity against a broad spectrum of FGFR-deregulated tumors in preclinical studies. In a previous study, futibatinib demonstrated clinical activity and tolerability in heavily pretreated pts with adv CCA harboring FGFR2 gene rearrangements. This phase 3 trial (FOENIX-CCA3) is designed to evaluate futibatinib vs gem-cis as 1L therapy for pts with adv iCCA harboring FGFR2 rearrangements. Methods: FOENIX-CCA3 is a multicenter, open-label, randomized phase 3 study that will be conducted in pts with metastatic or unresectable iCCA harboring FGFR2 rearrangements (assessed at screening by a central laboratory). Pts must have an ECOG performance status of 0 or 1 and should not have received previous systemic anticancer therapy for adv disease (adjuvant/neoadjuvant therapy ≥6 mo prior to randomization is permissible). Pts with clinically-significant alterations in calcium-phosphorus homeostasis or ectopic mineralization/calcification will be excluded. Approximately 216 pts will be randomized (1:1 ratio) to receive 20 mg futibatinib once daily until disease progression or other discontinuation criteria are met or gem-cis (on days 1 and 8 of a 21-day cycle) for 8 cycles or until disease progression, whichever occurs first. Pts will be stratified by prior surgical excision (yes vs no), geographic region, and locally adv vs metastatic disease. The primary endpoint is progression-free survival (PFS) assessed by independent central review (ICR). Secondary endpoints include objective response rate and disease control rate based on ICR, OS, PFS per investigator assessment, and safety. The anticipated start date is in April, 2020.
Time Domain Analysis of Current Transducer Responses Using Impulsive Signals (2021)

For the measurement of impulsive currents, which might occur in cases of electromagnetic interference, for example currents generated by the non-linear behavior of electronic appliances, a wide-band large dynamic range current transducer is needed. The electrical response of such a transducer is determined using conventional techniques, that use frequency sweeps of sinusoidal continuous wave signals. For non-linear and/or time invariant systems the superposition of continuous wave signals of multiple frequencies might not be equal to an impulsive current, which is representative for the actual measured signals, and is therefore of interest. In this letter the electrical response of current transducers is determined using impulsive signals, and compared to continuous wave tests. Time domain parameters such as rise time and peak amplitude are extracted, and the frequency response is analyzed using a Fourier transform. The experiments show that the impulsive test is in agreement with the continuous wave method and provides a good alternative method. A combination of impulses could cover a large bandwidth, and is a fast and cost effective approach.