gebhart/patrepeval huggingface dataset:
Pharmacological Characterization of Cyclic AMP Receptors Mediating Gene Regulation in Dictyostelium discoideum (1986)

Extracellular molecules regulate gene expression in eucaryotes. Exogenous cyclic AMP (cAMP) affects the expression of a large number of developmentally regulated genes in Dictyostelium discoideum. Here, we determine the specificity of the receptor(s) which mediates gene expression by using analogs of cAMP. The order of potency with which these analogs affect the expression of specific genes is consistent with the specificity of their binding to a cell surface receptor and is distinct from their affinity for intracellular cAMP-dependent protein kinase. Dose-response curves with cAMP and adenosine 3',5'-monophosphorothioate, a nonhydrolyzable analog, revealed that the requirement for high concentrations of exogenous cAMP for regulating gene expression is due to the rapid degradation of cAMP by phosphodiesterase. The addition of low concentrations of cAMP (100 nM) or analogs in pulses also regulates gene expression. Both the genes that are positively regulated by exogenous cAMP and the discoidin gene, which is negatively regulated, respond to cAMP analogs to the same degree. Genes expressed in prespore or prestalk cells are also similarly regulated. These data suggest that the effects are mediated through the same receptor. The specificity of this receptor is indistinguishable from that of the well-characterized cell surface cAMP receptor.
Bevacizumab for recurrent malignant gliomas (2008)

Combination therapy with bevacizumab and chemotherapy is well-tolerated and active against recurrent malignant gliomas. At recurrence, continuing bevacizumab and changing the chemotherapy agent provided long-term disease control only in a small subset of patients. Bevacizumab may alter the recurrence pattern of malignant gliomas by suppressing enhancing tumor recurrence more effectively than it suppresses nonenhancing, infiltrative tumor growth.
Shifts of Dependency in the Resolution of Folie à Deux (1993)

We have presented a case of folie à deux in which the wife was the primary (dominant) partner and the husband the secondary (submissive) partner. The husband's symptoms seemed to have resolved as his dependency shifted from his wife back to his mother. Treatment is recommended by deliberately shifting dependencies only when there is advantage in doing so. For most patients, the aim should be independence.
[Influence and assessment of biochar on the bioavailability of chlorobenzenes in soil]. (2012)

A laboratory experiment was conducted to study the influence of biochar on the residues of chlorobenzenes (CBs) in soil. Two treatments as the control and the addition of 1% wheat straw biochar were designed. Three chemical extractions as butanol, HPCD and Tenax extractions and earthworm accumulation were used to assess the changes of the bioavailability of CBs in soil. The results showed that the residues of HCB, PeCB and 1,2,4,5-TeCB in the control were 29.87%, 18.02% and 5.16% after 4 months incubation, however, the residues of HCB, PeCB and 1,2,4,5-TeCB in biochar amended soil were 68.25%, 61.32% and 58.02%, respectively, indicating that biochar amendment would inhibit the dissipation of CBs in soil. Butanol, HPCD and Tenax extraction as well as earthworm accumulation results demonstrated that the bioavailability of CBs in soil was significantly affected by biochar amendment (P < 0.05). With aging time increase, the biochar amendment significantly lowered the bioavailability of CBs. The extraction ratios differed among different chemical extraction methods. The extraction ratio was HCB > PeCB > 1,2,4,5-TeCB for butanol and Tenax extraction, while 1,2,4,5-TeCB > PeCB > HCB for HPCD extraction. The bioaccumulation factor of CBs by earthworm was significantly lower in biochar amended soil compared to the control (P < 0.05). This study showed that the biochar could reduce the bioavailability of organic pollutants, however, the high residues of the pollutants in soil showed potential environmental risk.
Properties of Food Grade (Edible) Surfactants Affecting Subsurface Remediation of Chlorinated Solvents (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTProperties of Food Grade (Edible) Surfactants Affecting Subsurface Remediation of Chlorinated SolventsBor-Jier. Shiau, David A. Sabatini, and Jeffrey H. HarwellCite this: Environ. Sci. Technol. 1995, 29, 12, 2929–2935Publication Date (Print):December 1, 1995Publication History Published online1 May 2002Published inissue 1 December 1995https://pubs.acs.org/doi/10.1021/es00012a007https://doi.org/10.1021/es00012a007research-articleACS PublicationsRequest reuse permissionsArticle Views932Altmetric-Citations57LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Content identification: binary content fingerprinting versus binary content encoding (2014)

In this work, we address the problem of content identification. We consider content identification as a special case of multiclass classification. The conventional approach towards identification is based on content fingerprinting where a short binary content description known as a fingerprint is extracted from the content. We propose an alternative solution based on elements of machine learning theory and digital communications. Similar to binary content fingerprinting, binary content representation is generated based on a set of trained binary classifiers. We consider several training/encoding strategies and demonstrate that the proposed system can achieve the upper theoretical performance limits of content identification. The experimental results were carried out both on a synthetic dataset with different parameters and the FAMOS dataset of microstructures from consumer packages.
Squamous cell carcinoma arising from mature cystic teratoma of the ovary: A clinicopathologic analysis. (2006)

목적: 난소의 성숙낭성기형종에서 기원한 편평상피세포암은 매우 드문 악성종양으로 아직 보고가 된 바가 많지 않다. 본 연구는 이러한 희귀 종양의 임상병리학적 특성 및 무병 생존율과 종양표지자의 유용성에 대하여 고찰하고자 한다. 연구 방법: 1990년 1월부터 2005년 12월까지 본원을 내원하여 수술시행 후 조직학적으로 난소의 성숙낭성기형종을 진단받은 1,266명의 환자들 중 난소의 성숙낭성기형종에서 기원한 편평상피세포암으로 진단된 8명의 환자를 대상으로 하였다. 이들의 임상병리학적 특성, 무병 생존율 및 종양표지자 등을 후향적 방법으로 고찰하였다. 결과: 난소의 성숙낭성기형종에서 발생한 편평상피세포암의 빈도는 0.7%이었고 평균 발병연령은 47.3세 (32-72세)였다. Clinical FIGO stage는 I기가 5명 (62.5%)으로 가장 많았고, III기가 3명 (37.5%)이었으며 평균 종양의 직경은 13.3㎝이었다. 평균 SCC Ag의 수치는 0.3 ng/mL로 모두 정상범위였고 CA는 125로 68.5 U/mL로 약간 증가되어 있었다. 평균 무병생존기간은 58.4개월이었으며 2년 무병 생존율은 62.5%였다. 8명 중 1명은 사망하였고 생존한 7명 중 1명은 재발한 상태였다. 환자의 나이, clinical FIGO stage, 조직학적 분화도, 잔류종양의 크기, 수술 후 추가적 치료여부에 따른 무병 생존율에 차이가 없어 예후인자로 통계학적 의미는 없었다. 결론: 본 기관에서의 난소의 성숙낭성기형종에서 발생한 편평상피세포암의 빈도는 비교적 낮고, 전체 무병 생존율이 양호한 것으로 판단된다. SCC Ag과 CA 125는 난소의 성숙낭성기형종에서 발생한 편평상피세포암의 진단에 도움을 주지 못하며 환자의 나이, clinical FIGO stage, 조직학적 분화도, 잔류종양의 크기, 수술 후 추가적 치료여부에 따른 무병 생존율에 차이가 없어 예후인자로 통계학적인 의미는 없었다.
A Learning-Based Framework for Engineering Feature-Oriented Self-Adaptive Software Systems (2013)

Self-adaptive software systems are capable of adjusting their behavior at runtime to achieve certain functional or quality-of-service goals. Often a representation that reflects the internal structure of the managed system is used to reason about its characteristics and make the appropriate adaptation decisions. However, runtime conditions can radically change the internal structure in ways that were not accounted for during their design. As a result, unanticipated changes at runtime that violate the assumptions made about the internal structure of the system could degrade the accuracy of the adaptation decisions. We present an approach for engineering self-adaptive software systems that brings about two innovations: 1) a feature-oriented approach for representing engineers' knowledge of adaptation choices that are deemed practical, and 2) an online learning-based approach for assessing and reasoning about adaptation decisions that does not require an explicit representation of the internal structure of the managed software system. Engineers' knowledge, represented in feature-models, adds structure to learning, which in turn makes online learning feasible. We present an empirical evaluation of the framework using a real-world self-adaptive software system. Results demonstrate the framework's ability to accurately learn the changing dynamics of the system while achieving efficient analysis and adaptation.
Acetylcholine receptors (muscarinic) in GtoPdb v.2023.1 (2023)

Muscarinic acetylcholine receptors (mAChRs) (nomenclature as agreed by the NC-IUPHAR Subcommittee on Muscarinic Acetylcholine Receptors [53]) are activated by the endogenous agonist acetylcholine. All five (M1-M5) mAChRs are ubiquitously expressed in the human body and are therefore attractive targets for many disorders. Functionally, M1, M3, and M5 mAChRs preferentially couple to Gq/11 proteins, whilst M2 and M4 mAChRs predominantly couple to Gi/o proteins. Both agonists and antagonists of mAChRs are clinically approved drugs, including pilocarpine for the treatment of elevated intra-ocular pressure and glaucoma, and atropine for the treatment of bradycardia and poisoning by muscarinic agents such as organophosphates. Of note, it has been observed that mAChRs dimerise reversibly [134] and that dimerisation/oligomerisation can be affected by ligands [183, 196].
Analysis of Time Series : An Introduction Ed. 6 (2003)

Since 1975, The Analysis of Time Series: An Introduction has introduced legions of statistics students and researchers to the theory and practice of time series analysis. With each successive edition, best-selling author Chris Chatfield has honed and refined his presentation, updated the material to reflect advances in the field, and presented interesting new data sets.The sixth edition is no exception. It provides an accessible, comprehensive introduction to the theory and practice of time series analysis. The treatment covers a wide range of topics, including ARIMA probability models, forecasting methods, spectral analysis, linear systems, state-space models, and the Kalman filter. It also addresses nonlinear, multivariate, and long-memory models. The author has carefully updated each chapter, added new discussions, incorporated new datasets, and made those datasets available for download from www.crcpress.comHighlights of the Sixth Edition:

 A new section on Handling Real Data
 New discussion on prediction intervals
 A completely revised and restructured chapter on more advanced topics, with new material on the aggregation of time series, analyzing time series in finance, and discrete-valued time series
 A new chapter of Examples and Practical Advice
 Thorough updates and revisions throughout the text that reflect recent developments and dramatic changes in computing practices over the last few years

The analysis of time series can be a difficult topic, but as this book has demonstrated for two-and-a-half decades, it does not have to be daunting. The accessibility, polished presentation, and broad coverage of The Analysis of Time Series make it simply the best introduction to the subject available.
Vorwort (1998)

Die vorliegende Untersuchung stellt weniger eine familiensoziologische Erforschung des Gegenstandes, als vielmehr eine sozialhistorische Entwicklungsanalyse dar. Zwar werden interdisziplinär sozialwissenschaftliche Instrumentarien angewandt und die Betrachtung sowohl auf der Makroebene des sozialistischen Staates als auch auf die Mikroebene der individuellen Familiensituation ausgeweitet, wobei jedoch immer die historisch-politische Entwicklung des zweiten deutschen Staates und die psychosozialen Auswirkungen auf die Menschen in der DDR mitberücksichtigt werden.
Investigation of the In Vitro Therapeutic Efficacy of Nilotinib in Immortalized Human NF2-Null Vestibular Schwannoma Cells (2012)

Vestibular schwannomas (VS) are a common posterior fossa brain tumor, and though benign can cause significant morbidity, particularly loss of hearing, tinnitus, vertigo and facial paralysis. The current treatment options for VS include microsurgical resection, stereotactic radiosurgery or close surveillance monitoring, with each treatment option carrying associated complications and morbidities. Most importantly, none of these options can definitively reverse hearing loss or tinnitus. Identification of a novel medical therapy, through the use of targeted molecular inhibition, is therefore a highly desirable treatment strategy that may minimize complications arising from both tumor and treatment and more importantly be suitable for patients whose options are limited with respect to surgical or radiosurgical interventions. In this study we chose to examine the effect of Nilotinib on VS. Nilotinib (Tasigna®) is a second-generation receptor tyrosine kinase (RTK) inhibitor with a target profile similar to that of imatinib (Gleevec®), but increased potency, decreased toxicity and greater cellular and tissue penetration. Nilotinib targets not only the BCR-ABL oncoprotein, but also platelet-derived growth factor (PDGF) receptor signalling. In this preclinical study, the human NF2-null schwannoma cell line HEI-193 subjected to nilotinib inhibition demonstrated decreased viability, proliferation and anchorage-independent growth, and increased apoptosis. A daily dose of nilotinib for 5 days inhibited HEI-I93 proliferation at a clinically-relevant concentration in a dose-dependent manner (IC(50) 3-5 µmol/L) in PDGF-stimulated cells. These anti-tumorigenic effects of nilotinib were correlated to inhibited activation of PDGFR-α and PDGFR-β and major downstream signalling pathways. These experiments support a therapeutic potential for Nilotinib in VS.
Visualizing Single-Cell Secretion Dynamics with Single-Protein Sensitivity (2017)

Cellular secretion of proteins into the extracellular environment is an essential mediator of critical biological mechanisms, including cell-to-cell communication, immunological response, targeted delivery, and differentiation. Here, we report a novel methodology that allows for the real-time detection and imaging of single unlabeled proteins that are secreted from individual living cells. This is accomplished via interferometric detection of scattered light (iSCAT) and is demonstrated with Laz388 cells, an Epstein-Barr virus (EBV)-transformed B cell line. We find that single Laz388 cells actively secrete IgG antibodies at a rate of the order of 100 molecules per second. Intriguingly, we also find that other proteins and particles spanning ca. 100 kDa-1 MDa are secreted from the Laz388 cells in tandem with IgG antibody release, likely arising from EBV-related viral proteins. The technique is general and, as we show, can also be applied to studying the lysate of a single cell. Our results establish label-free iSCAT imaging as a powerful tool for studying the real-time exchange between cells and their immediate environment with single-protein sensitivity.
A Numerical Solution for Viscoelastic Half Planes (1976)

The standard singular higher order transcendental functions, appearing in all the fundamental frequency domain response quantities of viscoelastic half planes, are identified and separated from the regular parts utilizing the notion of convolution algebra. The relevant mathematical properties of such logarithmic singularities have been investigated to recommend analytical differentiations and integrations in the space of distributions. Only the regular parts of the physical quantities are operated numerically. The foundation coefficients, both impedances and compliances, for the finite element analysis of soil-structure interaction problems, corresponding to any order of interpolation polynomial can be evaluated numerically using the algorithm developed here. Numerical results for the impedance coefficients and the foundation surface stress profiles associated with the finite element linear displacement field are illustrated as an example.
Myocardial first-pass perfusion cardiovascular magnetic resonance: history, theory, and current state of the art (2008)

In less than two decades, first-pass perfusion cardiovascular magnetic resonance (CMR) has undergone a wide range of changes with the development and availability of improved hardware, software, and contrast agents, in concert with a better understanding of the mechanisms of contrast enhancement. The following review provides a perspective of the historical development of first-pass CMR, the developments in pulse sequence design and contrast agents, the relevant animal models used in early preclinical studies, the mechanism of artifacts, the differences between 1.5T and 3T scanning, and the relevant clinical applications and protocols. This comprehensive overview includes a summary of the past clinical performance of first-pass perfusion CMR and current clinical applications using state-of-the-art methodologies.
18.3% efficient silicon solar cells for space applications (2002)

In this paper, the authors report on the development of high-efficiency silicon solar cells designed specifically for space applications. The cells are the 100 /spl mu/m thin N/sup +/-P-P/sup +/ and are 2/spl times/4 cm in size. The front side surface is textured with inverted pyramids and received a double layer anti-reflection coating (ARC). They also have a back surface field (BSF) and a back surface reflector (BSR). Both front and back diffusions are optimized for radiation hardness. The best beginning of life (BOL) efficiencies of these thin (100 /spl mu/m) 2 cm/spl times/4 cm cells have been measured At JPL to be 18.3%. The best end of life (EOL) efficiencies after 1 MeV 1E15 electrons is 12.1%.
Buildings-to-Grid Integration Framework (2017)

This paper puts forth a mathematical framework for Buildings-to-Grid (BtG) integration in smart cities. The framework explicitly couples power grid and building's control actions and operational decisions, and can be utilized by buildings and power grids operators to simultaneously optimize their performance. Simplified dynamics of building clusters and building-integrated power networks with algebraic equations are presented---both operating at different time-scales. A model predictive control (MPC)-based algorithm that formulates the BtG integration and accounts for the time-scale discrepancy is developed. The formulation captures dynamic and algebraic power flow constraints of power networks and is shown to be numerically advantageous. The paper analytically establishes that the BtG integration yields a reduced total system cost in comparison with decoupled designs where grid and building operators determine their controls separately. The developed framework is tested on standard power networks that include thousands of buildings modeled using industrial data. Case studies demonstrate building energy savings and significant frequency regulation, while these findings carry over in network simulations with nonlinear power flows and mismatch in building model parameters. Finally, simulations indicate that the performance does not significantly worsen when there is uncertainty in the forecasted weather and base load conditions.
New Polymer Syntheses. 103. In Situ End Group Modification of Hyperbranched Poly(3,5-dihydroxybenzoate) (1999)

3,5-Bis(trimethylsiloxy)benzoyl chloride (BTBC) was polycondensed with N,N‘-bis(trimethylsilyl)bisaniline-P in bulk with variation of the feed ratio. In this way star-shaped hyperbranched polyesters were prepared, and the average degree of polymerization (DP) was controlled by the monomer/comonomer (M/C) ratio. A star-shaped, hyperbranched polyester having a DP of 50 was treated with an excess of an acid chloride in refluxing 1-chloronaphthalene, and the trimethylsiloxy groups were almost quantitatively transformed into ester groups. The following acid chlorides were used: acetyl, chloroacetyl, undecenoyl, stearoyl, 4-methoxycinnamoyl, and perfluorooctanoyl. Due to the low boiling point, the acylation with acetyl chloride required two steps for completion. The solubilities and glass-transition temperatures varied largely with the nature of the end groups. Irradiation with UV light (254 nm) caused rapid cross-linking of films cast from poly(3,5-dihydroxybenzoate) bearing 4-methoxycinnamoyl end groups.
Construction and purification of site-specifically modified DNA templates for transcription assays (2003)

Chemical and physical agents can alter the structure of DNA by modifying the bases and the phosphate-sugar backbone, consequently compromising both replication and transcription. During transcription elongation, RNA polymerase complexes can stall at a damaged site in DNA and mark the lesion for repair by a subset of proteins that are utilized to execute nucleotide excision repair, a pathway commonly associated with the removal of bulky DNA damage from the genome. This RNA polymerase-induced repair pathway is called transcription-coupled nucleotide excision repair. Although our understanding of DNA lesion effects on transcription elongation and the associated effects of stalled transcription complexes on DNA repair is broadening, the attainment of critical data is somewhat impeded by labor-intensive, time- consuming processes that are required to prepare damaged DNA templates. Here, we describe an approach for building linear DNA templates that contain a single, site-specific DNA lesion and support transcription by human RNA polymerase II. The method is rapid, making use of biotin-avidin interactions and paramagnetic particles to purify the final product. Data are supplied demonstrating that these templates support transcription, and we emphasize the potential versatility of the protocol and compare it with other published methods.
Structure of bis(2,2'-bipyridyl)thiocyanatocopper(II) nitrate monohydrate (1988)

Cristallisation dans P1 avec affinement jusqu'a 0,041. L'atome de cuivre est penta coordine avec les quatre atomes d'azote des coordinats bipyridyle et l'atome d'azote du groupe thiocyanate, dans un arrangement trigonal bipyramidal
CACNA1C gene and schizophrenia (2015)

Our findings further support a role for the CACNA1C gene, particularly for the rs1006737, in SCZ. Further, five SNPs were associated with improvement in PANSS subscales, suggesting a role for this gene in antipsychotic response as well. However, taking into account the limitations of the present study, further research is needed to confirm our findings.
Synthesis and Properties of Monophospha‐ and Diphosphacyclodiynes (2018)

This paper reports the synthesis and characterization of a number of monocyclic systems with one or two phosphorus atoms in the scaffold. The cyclic systems with one P‐atom are: 1‐phosphacyclodeca‐3,8‐diyne, 1‐phosphacycloundeca‐3,9‐diyne, 1‐phosphacyclododeca‐3,10‐diyne, 1‐phosphacyclotrideca‐3,11‐diyne, 1‐phosphacyclotetradeca‐3,12‐diyne and 1‐phosphacyclotetradeca‐4,11‐diyne. The P‐centers in the rings were further stabilized by phenyl‐ or 2,4,6‐tri‐ tert ‐butylphenyl rings as third ligand and sulfur or oxygen atoms as fourth ligand. The rings with two P‐atoms are 1,8‐diphospha‐cyclotetradeca‐4,11‐diyne and 1,10‐diphosphacyclooctadeca‐5,14‐diyne, with phenyl rings and oxygen at the P‐centers. For many of the products the structures and conformations in the solid state were obtained by X‐ray studies.