gebhart/patrepeval huggingface dataset:
Synthesis of α,α‐Difluoro‐β‐amino Esters or gem‐Difluoro‐β‐lactams as Potential Metallocarboxypeptidase Inhibitors (2008)

Abstract The synthesis of gem ‐difluorinated β‐lactams and gem ‐difluorinated β‐amino acids, each possessing a potential basic functional group, from ethyl bromodifluoroacetate and either imines (for β‐lactams) or N ‐(α‐aminoalkyl)benzotriazoles (for β‐amino esters) was investigated. A series of these compounds were used for the design of novel metallocarboxypeptidase inhibitors. N ‐Alkylation and N ‐acylation of these two versatile scaffolds were carried out, leading to the expected targets in moderate to good yields.(© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2008)
Preincisional Dextromethorphan Combined with Thoracic Epidural Anesthesia and Analgesia Improves Postoperative Pain and Bowel Function in Patients Undergoing Colonic Surgery (2005)

Colonic surgery is associated with severe postoperative pain and postoperative ileus, which contribute to delayed hospital discharge. In previous studies, we demonstrated that IM dextromethorphan (DM) provided preemptive analgesia and improved postoperative pain. The benefit of thoracic epidural anesthesia (TEA) and postoperative epidural analgesia on postoperative pain was well demonstrated. The goal of this study was to investigate the effect of preincisional IM DM combined with intraoperative TEA and postoperative patient-controlled epidural analgesia (PCEA) on pain and bowel function after colonic surgery. Patients were randomized into 3 equal groups to receive: 1) chlorpheniramine maleate (CPM) 20 mg and general anesthesia (CPM-GA); 2) CPM 20 mg and GA combined with TEA (CPM-TEA); or 3) DM 40 mg (containing 20 mg of CPM) and GA combined with TEA (DM-TEA). The CPM, DM, and TEA with lidocaine were administered after GA induction via an IM injection and 30 min before the skin incision. All patients received postoperative PCEA for pain control. Analgesic effects were evaluated for 72 h after surgery using visual analog scale pain scores at rest and moving, time to first PCEA request for pain relief, total PCEA consumption, and the time to first passage of flatus. Statistically significant improvement of postoperative pain and bowel function was observed in the following order: DM-TEA > CPM-TEA > CPM-GA. Compared with the CPM-TEA group, the DM-TEA group averaged 1.6 points lower on first-hour pain scores, 40 min longer to first PCEA request, 15.8 mL less PCEA drug over 72 h, and 14.7 h earlier bowel function (all P < 0.01). We conclude that the combination of preincisional DM (40 mg IM), intraoperative TEA, and postoperative PCEA enhances analgesia and facilitates recovery of bowel function, suggesting possible synergistic interaction with local anesthetics and opioids.
Implicit Function Modeling of Solidification in Metal Castings (1997)

Solidification of metal castings can be modeled by an implicit real-valued function whose behavior is determined by physical parameters prescribed on the boundary of a casting. We show how to construct such functions using theory of R-functions for two-dimensional castings represented by their boundaries. The parameterized form of the constructed functions is convenient for studying, controlling, and optimizing their behavior in terms of the physical parameters specified on the boundary of the casting. The proposed approach can also be used for modeling multiple cavities in a same sand mold, generalizes to three-dimensional castings, and is applicable to other physical phenomena that may be suitable for analysis based on empirical knowledge.
An Approach to QoS-based Task Distribution in Edge Computing Networks for IoT Applications (2017)

Internet of Things (IoT) is emerging as part of thn infrastructures for advancing a large variety of applications involving connection of many intelligent devices, leading to smart communities. Due to the severe limitation on the computing resources of IoT devices, it is common to off load tasks of various applications requiring substantial computing resources to computing systems with sufficient computing resources, such as servers, cloud systems, and/or data centers for processing. However, the off loading method suffers from the difficulties of high latency and network congestion in the IoT infrastructures. Recently edge computing has emerged to reduce the negative impacts of these difficulties. Yet, edge computing has its drawbacks, such as the limited computing resources of some edge computing devices and the unbalanced load among these devices. In order to effectively explore the potential of edge computing to support IoT applications,it is necessary to have efficient task management in edge computing networks. In this paper, an approach is presented to periodically distributing incoming tasks in the edge computing network so that the number of tasks, which can be processed in the edge computing network, is increased, and the quality of-service (QoS) requirements of the tasks completed in the edge computing network are satisfied. Simulation results are presented to show the improvement of using this approach on the increase of the number of tasks to be completed in the edge computing network.
Ovalbumin: a secreted protein without a transient hydrophobic leader sequence. (1978)

Ovalbumin mRNA was translated in a reticulocyte lysate. The primary translation product starts with methionine derived from Met-tRNAf. When the nascent polypeptide is about 20 residues long, this methionine is removed. The new NH2-terminal glycine is acetylated from acetyl-CoA when the polypeptide is 44 residues long. The sequence of 35 residues at the NH2 terminus of ovalbumin was determined by automated Edman degradation after a method was devised to prevent acetylation during protein synthesis in the reticulocyte lysate. This sequence is the same as that of secreted ovalbumin and does not resemble the transient "signal peptides" associated with most secretory proteins, including three other egg white proteins synthesized in the same cells as ovalbumin.
Expression of bacterial genes and induction of INF-Î³ in human myeloid dendritic cells during persistent infection withChlamydophila pneumoniae (2008)

The interactions between human monocyte-derived dendritic cells (DCs) and Chlamydophila pneumoniae (Cpn) infection were investigated. Cpn infection induced the maturation and functional activation of DCs, and Cpn antigens were present in all of the subpopulations during the maturation process. Chlamydial antigens were detected in DCs during an observation period of 28 days. The exponential production of infectious elementary bodies was not observed. Chlamydial transcripts of the 16S rRNA gene, groEL-1 and omcB genes were expressed, as determined by a quantitative real-time PCR, but the expression of the ftsK gene was limited. DC cultures produced IFN-gamma, but the presence of IFN-gamma in the culture medium was not the major factor that decreased the growth of Cpn, as was shown by neutralization of the IFN-gamma. A cell population identified as producing IFN-gamma had no markers for T, B, natural killer, monocyte cells or macrophages but displayed DC morphology and the expression of specific DC markers, such as CD11c and HLA-DR. These results reveal a persistent infection of DCs with the expression of some, but not cell division-related genes and the production of IFN-gamma that may contribute to the pathomechanism of chronic inflammatory diseases associated with persistent Cpn infection.
Next-generation dithiocarbamate carbonic anhydrase inhibitors (2014)

Dithiocarbamates (DTCs) are chemically referred to as functional groups analogs to the carbamates, containing sulfur instead of oxygen atoms. Herein we report the kinetic results of a series of DTC-containing compounds tested on α and β-carbonic anhydrases (EC 4.2.1.1). The DTCs binding mode was also investigated by means of crystallographic experiments of the selected DTC 10, 11 and 14 in adduct with human carbonic anhydrase II.
Stochastic gesture production and recognition model for a humanoid robot (2005)

Robot programming by demonstration (PbD) aims at developing adaptive and robust controllers to enable the robot to learn new skills by observing and imitating a human demonstration. While the vast majority of PbD works has focused on systems that learn a specific subset of tasks, our work explores the problem of recognizing, generalizing, and reproducing tasks in a unified mathematical framework. The approach makes abstraction of the task and dataset at hand to tackle the general issue of learning which of the features are the relevant ones to imitate. In this paper, we present an implementation of this framework to the determination of the optimal strategy to reproduce arbitrary gestures. The model is tested and validated on a humanoid robot, using recordings of the kinematics of the demonstrator's arm motion. The hand path and joint angle trajectories are encoded in hidden Markov models. The system uses the optimal prediction of the models to generate the reproduction of the motion.
A Coupled EXAFS–Molecular Dynamics Study on PuO2+ and NpO2+ Hydration: The Importance of Electron Correlation in Force-Field Building (2022)

The physicochemical properties of the monovalent actinyl cations, PuO<sub>2</sub><sup>+</sup> and NpO<sub>2</sub><sup>+</sup>, in water have been studied by means of classical molecular dynamic simulations. A specific set of cation-water intermolecular potentials based on ab initio potential energy surfaces has been built on the basis of the hydrated ion concept. The TIP4P water model was adopted. Given the paramagnetic character of these actinyls, the cation-water interaction energies were computed from highly correlated wave functions using the NEVPT2 method. It is shown that the multideterminantal character of the wave function has a relevant effect on the main distances of the hydrated molecular cations. Several structural, dynamical, and energetic properties of the aqueous solutions have been obtained and analyzed. Structural RDF analysis gives An-O<sub>yl</sub> distances of 1.82 and 1.84 Å and An-O(water) distances of 2.51 and 2.53 Å for PuO<sub>2</sub><sup>+</sup> and NpO<sub>2</sub><sup>+</sup> in water, respectively. Experimental EXAFS spectra from dilute aqueous solutions of PuO<sub>2</sub><sup>+</sup> and NpO<sub>2</sub><sup>+</sup> are revisited and analyzed, assuming tetra- and pentahydration of the actinyl cations. Simulated EXAFS spectra have been computed from the snapshots of the MD simulations. Good agreement with the experimental information available is found. The global analysis leads us to conclude that both PuO<sub>2</sub><sup>+</sup> and NpO<sub>2</sub><sup>+</sup> cations in water are stable pentahydrated aqua ions.
ALTAIR: automatic location tracking system using active IR-tag (2003)

This paper proposes a new location-awareness system ALTAIR (automatic location tracking system using active IR-tag) that automatically detects and tracks the location of the mobile PC (personal computer) users. IR-tag (infrared) is a small electrical device to indicate its location by emitting IR light and reliable detected by a camera with IR-pass filter. IR-tag is installed on a mobile PC, which has wireless LAN (local area network) connection so that ALTAIR controls lighting pattern and activating time of individual IR-tag through the network. ALTAIR identifies visually detected position of the IR-tag with the IP (Internet protocol) address whom the system requires to change the lighting pattern. Utilizing DHCP (dynamic host configuration protocol) service, ALTAIR stars to aware the position of the mobile PC user when he/she enters the area within ALTAIR's coverage. Prototype ALTAIR shows the effective performance for tracking and recognizing multiple users' positions in an office environment.
Miniaturised Prandtl tube with integrated pressure sensors for micro-thruster plume characterisation (2014)

A miniaturised Prandtl-tube sensor incorporating a 6 mm long 40 μm diameter microchannel with integrated pressure sensors has been realised. The sensor has been designed for the characterisation of rarefied plume flow from a MEMS-based monopropellant propulsion system for high-accuracy attitude control of satellites. The 4.5 × 2.5 mm sensor chip incorporates 400 mbar full-scale capacitive pressure sensors. The capacitive pressure transducer is created by merging several microchannels into a rectangular pressure membrane, with outward-facing comb-fingers hinging on the microchannel sidewall. Additionally, thermistors can measure the temperature profile on the Prandtl tube and an integrated Pirani sensor can optionally measure vacuum pressures below 10 mbar. An electronics board and stainless steel probe, from which only the Prandtl tube protrudes has been realised. Initial plume measurements of dynamic pressure on the Prandtl tube have been obtained by flowing air from a metal tube with 0.7 mm diameter, demonstrating the feasibility of the miniaturised Prandtl-tube sensor.
Sensitivity Analysis on the Blast Resistance of Steel Concrete Structure Wall Based on CONWEP (2021)

Abstract In the modern society, more and more explosive accidents and explosive terror attacks have happened around the world. These explosions not only inflict heavy casualties and property loss, but also cause serious damage to related structures. The outer wall of the nuclear island plant of newly constructed nuclear power unit is usually designed as the steel concrete (SC) structure to prevent from explosion and aircraft impact. This paper selects the steel concrete structure wall composed of surface steel plate, stud, tie bar and concrete as the study object. It adopts classical explicit nonlinear dynamic analysis software ANSYS/LS-DYNA to conduct a series of parameter sensitivity analysis on the impact of blast resistance of the steel concrete structure wall based on the CONWEP method. These parameters include: the explosive scaled distance, thickness of the steel plate, thickness and grade of the concrete, diameter and spacing of tie bars, etc. The analysis results indicate that the above mentioned parameters, especially the explosion scaled distance, the thickness of the wall and the spacing of tie bars, affect the blast resistance capacity of the wall. This paper contributes to the guiding and referencing significance for the design and optimization of the steel concrete structure outer wall of nuclear island plant.
Diagnostics and treatment of relapsing fever Borrelia (2007)

Relapsing fever (RF) is a disease caused by tick- or louse-transmitted bacteria of the genus Borrelia. It occurs worldwide but is most common in Africa where it is one of the most prevalent bacterial diseases. The main manifestation is a recurring fever which coincides with massive numbers of bacteria in the blood. Severity ranges from asymptomatic to fatal.RF is usually considered a transient disease. In contrast, B. duttonii causes a persistent, residual brain infection in C57BL/6 mice which remains long time after the bacteria are cleared from the blood. The host gene expression pattern is indistinguishable from that of uninfected animals, indicating that persistent bacteria are not recognized by the immune system nor do they cause noticeable tissue damage. This is probably due to the quite low number of bacteria residing in the brain. The silent infection can be reactivated by immunosuppression allowing bacteria to re-enter the blood. To investigate if the residual infection is in a quiescent state or if the bacteria are actively dividing, mice with residual brain infection were treated with the cell-wall disrupting antibiotic ceftriaxone, which is only active against dividing bacteria. Since all mice were cured by ceftriaxone we conclude that the bacteria are actively growing in the brain rather than being in a latent, dormant state. The brain is used as an immunoprivileged site to escape host immune defence and probably as a reservoir for bacteria.RF is a common cause of pregnancy complications, miscarriage and neonatal death in sub-Saharan Africa. We established a murine model of gestational relapsing fever to study the pathological development of these complications. B. duttonii infection during pregnancy results in intrauterine growth retardation as well as placental damage and inflammation. Spirochetes cross the maternal-foetal barrier, resulting in congenital infection. Further, pregnancy has a protective effect, resulting in milder disease during pregnancy.A clinic-based study to investigate the presence of RF in Togo was performed. Blood from patients with fever were examined for RF by microscopy, GlpQ ELISA and PCR. About 10% of the patients were positive by PCR and 13% had antibodies to GlpQ. Many RF patients originally had a misdiagnosis of malaria, which resulted in ineffective treatment. The inability of microscopic analysis to detect spirochetes demonstrates the need for tests with greater sensitivity. To provide simple, fast, cheap and sensitive diagnostics using equipment available in small health centres, a method based on enrichment of bacteria by centrifugation and detection by Giemsa staining was developed which detects To study the phylogeny of RF, IGS and glpQ were sequenced and neighbor joining trees were constructed. B. persica and B. hispanica were distant from the other species iswhereas B. crocidurae appeared to be a heterogeneous species. B. duttonii is polyphyletic in relation to B. recurrentis suggesting that the two species may in fact be the same or have a polyphyletic origin.
Reactions of Peracids. VII. Nuclear Oxidation of Aromatic Ethers with Perbenzoic Acid (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of Peracids. VII. Nuclear Oxidation of Aromatic Ethers with Perbenzoic AcidS. L. Friess, A. H. Soloway, B. K. Morse, and W. C. IngersollCite this: J. Am. Chem. Soc. 1952, 74, 5, 1305–1309Publication Date (Print):March 1, 1952Publication History Published online1 May 2002Published inissue 1 March 1952https://pubs.acs.org/doi/10.1021/ja01125a048https://doi.org/10.1021/ja01125a048research-articleACS PublicationsRequest reuse permissionsArticle Views275Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Prognostic Role of Plasma PD-1, PD-L1, pan-BTN3As and BTN3A1 in Patients Affected by Metastatic Gastrointestinal Stromal Tumors: Can Immune Checkpoints Act as a Sentinel for Short-Term Survival? (2021)

Gastrointestinal stromal tumors (GISTs) represent 1% of all primary gastrointestinal tumors. Immune surveillance is often overcome by cancer cells due to the activation of immunoregulatory molecules such as programmed death protein (PD-1) and its ligand PD-L1, and butyrophilin sub-family 3A/CD277 receptors (BTN3A). Because several studies demonstrated that tumor PD-1 and PD-L1 expression may have a prominent prognostic function, this investigation aimed to discover if soluble forms of these molecules may be useful in predicting survival of metastatic GIST (mGIST) patients. Through specific ad hoc developed ELISA assays not yet available on the market, the circulating PD-1, PD-L1, BTN3A1, and pan-BTN3As levels were examined in 30 <i>c-KIT</i> exon 11-mutated mGIST patients, prior to imatinib therapy. Using specific thresholds derived by ROC analysis, we found that high baseline levels of sPD-1 (>8.1 ng/mL), sPD-L1 (>0.7 ng/mL), sBTN3A1 (>7.0 ng/mL), and pan-BTN3As (>5.0 ng/mL) were correlated with shorter progression-free survival (PFS) and poor prognosis. Contrariwise, subjects with lower plasma concentrations exhibited a median PFS about 20 months longer than to the earlier. Finally, an additional multivariate analysis revealed that circulating levels of sPD-L1 ≤ 0.7 ng/mL and pan-sBTN3As ≤ 5.0 ng/mL, and the absence of <i>KIT</i> exon 11 deletions or delins at codons 557 and/or 558 were associated with a longer PFS in mGIST patients. Our investigation, for the first time, revealed that evaluating the plasma concentration of some immune checkpoints may help prognosticate survival in mGIST patients, suggesting their potential use as prognostic biomarkers beyond the presence of <i>KIT</i> exon 11 Del or Delins at codons 557/558.
Few-mode optical fibers for application in future telecommunication networks (2022)

Increasing demand for high data transmission rates and bandwidth availability driven by the rapid development of the broadband services becomes challenging in the context of constraints imposed by nowadays exploited telecommunication optical fibers. Based on single-mode fibers and multiplexing in the wavelength domain (wavelength division multiplexing, WDM), the current technology seems to have reached its fundamental limits. At present, two promising technologies are a subject of intensive research. One of them is the increase of the data transmission through multiplying the number of fiber cores, thus implementing the concept of Multi-Core Fibers (MCF), where each core is used as a separate data transmission channel. The second widely investigated technique is based on the idea of mode division multiplexing (MDM), where different transverse modes of a Few-Mode Fiber (FMF) can be used as different carriers for data channels. In this work, we demonstrate the results of R&D works and the comprehensive tests of the few-mode fibers developed within the project NMKM+. Developed few-mode fibers (both passive and active) and their commercially available counterparts have been tested with respect of transmission parameters and applicability to the real telecom systems. In particular, guided mode profiles, numerical apertures, OTDR, and dispersion characteristics for the passive fibers have been recorded and compared. Also, methods of selective excitation and detection of singular modes have been discussed and partially verified. The results of data transmission experiments have been performed and discussed with respect to the quality of transmitted signals. These have been complemented by the amplification experiments with the use of erbium-doped few-mode fibers in “classical” and microstructural geometry. The results were studied and analyzed, showing the potential for future optimization. Acknowledgement: This work has received support from the National Centre for Research and Development through project NMKM+ (TECHMATSTRATEG1/348438/16/NCBR/2018).