gebhart/patrepeval huggingface dataset:
Modeling Services for the Semantic Grid (2005)

The Grid has emerged as a new distributed computing infrastructure for ad- vanced science and engineering aiming at enabling sharing of resources and infor- mation towards coordinated problem solving in dynamic environments. Research in Grid Computing and Web Services has recently converged in what is known as the Web Service Resource Framework. While Web Service technologies and standards such as SOAP and WSDL provide the syntactical basis for communi- cation in this framework, a service oriented grid architecture for communication has been defined in the Open Grid Service architecture. Wide agreement that a flexible service Grid is not possible without support by Semantic technologies has lead to the term "Semantic Grid" which is at the moment only vaguely defined. In our ongoing work on the Web Service Modeling Ontology (WSMO) we so far concentrated on the semantic description of Web services with respect to applications in Enterprise Application Integration and B2B integration sce- narios. Although the typical application areas of Semantic Web services have slightly different requirements than the typical application scenarios in the Grid a big overlap justifies the assumption that most research results in the Semantic Web Services area can be similarly applied in the Semantic Grid. The present abstract summarizes the authors view on how to fruitfully in- tegrate Semantic Web service technologies around WSMO/WSML and WSMX and Grid technologies in a Semantic Service Grid and gives an outlook on further possible directions and research. The reminder of this abstract is structured as follows. After giving a short overview of the current Grid Service architecture and its particular requirements, we shortly review the basic usage tasks for Semantic Web services. We then point out how these crucial tasks of Semantic Web services are to be addressed by WSMO. In turn, we try to analyze which special requirements for Semantic Web Services arise with respect to the Grid. We conclude by giving an outlook on the limitations of current Semantic Web services technologies and how we plan to address these in the future in a common Framework for Semantic Grid services.
Crown ether complexes of molecular bromine as stereoselective brominating agents (1979)

K. H. Pannell and A. Mayr, J. Chem. Soc., Chem. Commun., 1979, 132 DOI: 10.1039/C39790000132
Data from Chronic Bile Duct Injury Associated with Fibrotic Matrix Microenvironment Provokes Cholangiocarcinoma in p53-Deficient Mice (2023)

&lt;div&gt;Abstract&lt;p&gt;Intrahepatic cholangiocarcinoma (CCA) is a lethal malignancy of the biliary epithelium associated with p53 mutations, bile duct injury, inflammation, and fibrosis. Here, to validate these processes in CCA, we developed a liver cirrhosis model driven by chronic intermittent toxin exposure, which provokes bile duct injury/necrosis and proliferation, fibroblast recruitment, and progressive extracellular matrix (ECM) changes. Fibrotic changes in the matrix microenvironment, typified by increased type I and III collagens and fibroblast recruitment, were shown to stimulate biliary epithelium hyperplasia with subsequent progression to malignant intrahepatic CCA only in mice harboring a &lt;i&gt;p53&lt;/i&gt; mutant allele. These murine CCAs bear histologic and genetic features of human intrahepatic CCA, including dense peritumoral fibrosis, increased inducible nitric oxide synthase, nitrotyrosine, and cyclooxygenase-2 expression, c-Met activation, cErbB2 overexpression, down-regulation of membrane-associated E-cadherin, and p53 codon 248 mutation. Thus, p53 deficiency, chronic bile duct injury/proliferation, and the fibrotic matrix microenvironment cooperate to induce intrahepatic CCA, highlighting the key role of the ECM microenvironment in this common liver cancer. (Cancer Res 2006; 66(13): 6622-7) (Cancer Res 2006; 66(13): 6622-7)&lt;/p&gt;&lt;/div&gt;
Progression of meiotic recombination requires structural maturation of the central element of the synaptonemal complex (2008)

The synaptonemal complex is an elaborate meiosis-specific supramolecular protein assembly that promotes chromosome synapsis and meiotic recombination. We inactivated the meiosis-specific gene Tex12 and found that TEX12 is essential for progression of meiosis in both male and female germ cells. Structural analysis of the synaptonemal complex in Tex12-/- meiocytes revealed a disrupted central element structure, a dense structure residing between the synapsed homologous chromosomes. Chromosome synapsis is initiated at multiple positions along the paired homologous chromosomes in Tex12-/- meiotic cells, but fails to propagate along the chromosomes. Furthermore, although meiotic recombination is initiated in Tex12-/- meiotic cells, these early recombination events do not develop into meiotic crossovers. Hence, the mere initiation of synapsis is not sufficient to support meiotic crossing-over. Our results show that TEX12 is a component of the central element structure of the synaptonemal complex required for propagation of synapsis along the paired homologous chromosomes and maturation of early recombination events into crossovers.
Arthropod Studies with Rabies-Related Mokola Virus (1984)

A cell culture-adapted variant of the rabies-related Mokola virus was demonstrated to replicate in inoculated Aedes aegypti mosquitoes. Replication was slow compared to many arboviruses in their vectors. Maximum titers were not obtained until after approximately 6 weeks of extrinsic incubation. Mokola virus underwent nine mosquito-mosquito passages at approximately monthly intervals and was thus maintained in insects for 340 days before terminating the study. Virus antigen was detected by immunofluorescence in a variety of mosquito tissues and organs, including salivary glands, but primarily in nervous tissue. Irrefutable virus transmission by bite could not be demonstrated because of equivocal results. Transovarial passage of virus was observed in the mosquito. Viremia in baby mice was demonstrable. Ornithodoros moubata nymphal ticks were exposed to viremic mice but failed to become infected.
LRRK2 and Rab10 Coordinate Macropinocytosis to Mediate Immunological Responses in Phagocytes (2020)

Abstract Genetic variation in LRRK2 associates with susceptibility to Parkinson’s disease, Crohn’s disease, and mycobacteria infection, with high expression of LRRK2, and the LRRK2 kinase substrate Rab10, in phagocytic cells in the immune system. In mouse and human primary monocyte-derived macrophages, dendritic cells, and microglia-like cells, we find that Rab10 specifically regulates a specialized form of endocytosis known as macropinocytosis, without affecting phagocytosis or clathrin-mediated endocytosis. LRRK2 phosphorylates cytoplasmic PI(3,4,5)P 3 -positive GTP-Rab10 early macropinosomes, before EEA1 and Rab5 recruitment occurs. Macropinosome cargo in macrophages includes CCR5, CD11b, and MHCII, with LRRK2-phosphorylation of Rab10 potently blocking EHBP1L1-mediated recycling tubules and cargo turnover. EHBP1L1 over-expression competitively inhibits LRRK2-phosphorylation of Rab10, mimicking the effects of LRRK2 kinase inhibition in promoting cargo recycling. Both Rab10 knockdown and LRRK2 kinase inhibition potently suppresses the maturation of macropinosome-derived CCR5-loaded signaling endosomes important for CCL5-induced AKT-activation and chemotaxis. These data support a novel axis in the endolysosomal system whereby LRRK2-mediated Rab10 phosphorylation stalls vesicle fast-recycling to promote PI3K-AKT signal transduction.
Annexin‐1 (Lipocortin‐1)‐Immunoreactivity in the Folliculo‐Stellate Cells of Rat Anterior Pituitary: The Effect of Adrenalectomy and Corticosterone Treatment on Its Subcellular Distribution (2002)

In the pituitary gland, annexin-1 (lipocortin-1) located in folliculo-stellate (FS) cells has been advocated as one of the candidates for paracrine agents produced by FS cells that modulate the release of pituitary hormones. However, the expression and distribution pattern of annexin-1 in FS cells under different circulating corticosteroid conditions has not been examined. Thus, by means of pre-embedding immunoelectron microscopy, we investigated the expression of annexin-1 in FS cells under different corticosteroid conditions. Annexin-1-immunoreactivity was observed in the cytoplasm; especially intense immunoreactivity was detected in the follicle surface of FS cells under control conditions. After adrenalectomy, annexin-1-immunoreactivity almost disappeared, but the immunoreactivity recovered with corticosterone replacement. The expression of glucocorticoid receptor immunoreactivity in the nucleus of FS cells also showed a similar pattern to annexin-1 associated with the changes in the corticosteroid conditions. However, S-100 immunoreactivity, a marker for FS cells, was not changed whatever the corticosteroid conditions. These results confirm that glucocorticoids regulate the annexin-1 expression and demonstrate the translocation of annexin-1 from intracellular to pericellular sites in the FS cells of the rat anterior pituitary gland.
Die gesetzgeberische Umsetzung des Rozenblum-Konzepts – dargestellt am Beispiel ostmitteleuropäischer Rechtsordnungen (2016)

Die gesetzgeberische Umsetzung des Rozenblum-Konzepts – dargestellt am Beispiel ostmitteleuropäischer Rechtsordnungen was published in Corporate Governance im grenzüberschreitenden Konzern on page 197.
Characterizing Properties of Magnetic Films Deposited on Silicon Wafers (2014)

Silicon samples sputtered with multiple magnetic layers can be characterized by using x-ray diffraction (XRD), vibrating sample magnetometry (VSM), and magneto-optical Kerr effect (MOKE) techniques. XRD identifies the crystallographic structures and chemical composition of the unknown layers. VSM measures the change in magnetic moment versus applied field, thus giving the information needed to find film thickness. MOKE characterizes the many magnetic properties of the sample, including Hp, Hk, and coercivity. Both, VSM and MOKE, are highly sensitive magnetometers and operate easily for electronic machines to date capable of quantifying both intrinsic and surface magnetization properties.
Monocyte-Astrocyte Networks Regulate Matrix Metalloproteinase Gene Expression and Secretion in Central Nervous System Tuberculosis In Vitro and In Vivo (2007)

CNS tuberculosis (CNS-TB) is the most deadly form of tuberculous disease accounting for 10% of clinical cases. CNS-TB is characterized by extensive tissue destruction, in which matrix metalloproteinases (MMPs) may play a critical role. We investigated the hypothesis that Mycobacterium tuberculosis activates monocyte-astrocyte networks increasing the activity of key MMPs. We examined the expression of all human MMPs and the tissue inhibitors of metalloproteinases (TIMPs) in human astrocytes stimulated by conditioned medium from M. tuberculosis-infected monocytes (CoMTB). Real-time RT-PCR showed that gene expression of MMP-1, -2, -3, -7, and -9 was increased (p < 0.05). MMP-9 secretion was significantly up-regulated at 24 h and increased over 120 h (p < 0.01). MMP-1, -3, and -7 secretion was not detected. Secretion of MMP-2 was constitutive and unaffected by CoMTB. Astrocyte gene expression and secretion of TIMP-1 was not affected by CoMTB although TIMP-2 secretion increased 3-fold at 120 h. Immunohistochemical analysis of human brain biopsies confirmed that astrocyte MMP-9 secretion is a predominant feature in CNS-TB in vivo. Dexamethasone inhibited astrocyte MMP-9, but not TIMP-1/2 secretion in response to CoMTB. CoMTB stimulated the nuclear translocation of NF-kappaB, inducing a 6-fold increase in nuclear p65 and a 2-fold increase in nuclear p50. This was associated with degradation of IkappaBalpha and beta within 30 min, persisting for 24 h. In summary, networks active between monocytes and astrocytes regulate MMP-9 activity in tuberculosis and astrocytes are a major source of MMP-9 in CNS-TB. Astrocytes may contribute to a matrix degrading environment within the CNS and subsequent morbidity and mortality.
Rationale, Design, and Progress of the ENhanced Control of Hypertension ANd Thrombolysis Stroke Study (ENCHANTED) Trial: An International Multicenter 2 × 2 Quasi-Factorial Randomized Controlled Trial of Low- vs. Standard-Dose rt-PA and Early Intensive vs. Guideline-Recommended Blood Pressure Lowering in Patients with Acute Ischaemic Stroke Eligible for Thrombolysis Treatment (2015)

Low-dose i.v. rt-PA and early intensive BP lowering could provide more affordable and safer use of thrombolysis treatment for patients with AIS worldwide.
Training Wideband Acoustic Models using Mixed-Bandwidth Training Data via Feature Bandwidth Extension (2006)

One serious difficulty in the deployment of wideband speech recognition systems for new tasks is the expense in both time and cost of obtaining sufficient training data. A more economical approach is to collect telephone speech and then restrict the application to operate at the telephone bandwidth. However, this generally results in sub-optimal performance. We propose a new algorithm for training wideband acoustic models that requires only a small amount of wideband speech augmented by a larger amount of narrowband speech. The algorithm operates by first converting the narrowband features to wideband features through a process called feature bandwidth extension. The bandwidth-extended features are then combined with available wideband data to train the acoustic models using a modified version of the conventional forward-backward algorithm. Experiments performed using wideband speech and telephone speech demonstrate that the proposed mixed-bandwidth training algorithm results in significant improvements in recognition accuracy over conventional training strategies when the amount of wideband data is limited.
High resolution processing of hybridstrip-map/spotlight mode SAR (1996)

Synthetic aperture radars have traditionally operated in either the spotlight mode, in which the coverage is limited, or in the strip-map mode, in which the resolution is limited. It is shown that, by steering the radar antenna about a point further away from the radar than the centre of the area being imaged, illumination times between that of strip-map and spotlight mode are achieved, thus resulting in different combinations of resolutions and spot sizes than is the case for traditional spotlight mode. The theory underlying this mode is derived from first principles, and it is shown that strip-map and spotlight modes are limiting cases. A wavenumber domain processing technique is presented that correctly compensates for range curvature and its equivalence to range Doppler processing described mathematically. This technique results in focused images and is applied to both simulated and real data. The advantages of this mode are a reduced data rate at high resolution, the use of a higher gain antenna, and achieving high resolution over an area larger than that possible in the spotlight mode. This technique may be applied to both space and airborne radar where a combination of high resolution and wide area coverage is important.
Transparent Ceramics Made of Non-Isometric Crystals (2019)

To expand the possibility of laser ceramics, we proposed the magnetic orientation control of microdomains in polycrystalline ceramics made of non-isometric crystals. Here the design of the extensive variables in Gibbs energy by inducing 4 f electrons of the rare-earth trivalent into the controlled microdomains enhanced the motive forces and torques under the applied external magnetic field. The orientation control of the microdomains reduced the birefringent scattering loss in the anisotropic ceramics and it enabled them to be transparent. With this technology we achieved anisotropic laser ceramics for the first time in the world. We expect to increase the optical power extracted per unit volume in the gain media using anisotropic laser ceramics.
Functional IsK/KvLQT1 Potassium Channel in a New Corticosteroid-sensitive Cell Line Derived from the Inner Ear (2006)

Endolymph, a high K(+)/low Na(+) fluid, participates in mechanoelectrical transduction in inner ear. Molecular mechanisms controlling endolymph ion homeostasis remain elusive, hampered by the lack of appropriate cellular models. We established an inner ear cell line by targeted oncogenesis. The expression of SV40 T antigen was driven by the proximal promoter of the human mineralocorticoid receptor (MR) gene, a receptor expressed in the inner ear. The EC5v cell line, microdissected from the semicircular canal, grew as a monolayer of immortalized epithelial cells forming domes. EC5v cells exhibited on filters of high transepithelial resistance and promoted K(+) secretion and Na(+) absorption. Functional MR and the 11beta-hydroxysteroid dehydrogenase type 2, a key enzyme responsible for MR selectivity were identified. Expression of the epithelial sodium channel and serum glucocorticoid-regulated kinase 1 was shown to be up-regulated by aldosterone, indicating that EC5v represents a novel corticosteroid-sensitive cell line. Ionic measurements and (86)Rb transport assays revealed an apical secretion of K(+) at least in part through the I(sK)/KvLQT1 potassium channel under standard culture conditions. However, when cells were exposed to high apically K(+)/low Na(+) fluid, mimicking endolymph exposure, I(sK)/KvLQT1 actually functioned as a strict apical to basolateral K(+) channel inhibited by clofilium. Quantitative reverse transcriptase-PCR further demonstrated that expression of KvLQT1 but not of I(sK) was down-regulated by high K(+) concentration. This first vestibular cellular model thus constitutes a valuable system to further investigate the molecular mechanisms controlling ionic transports in the inner ear and the pathophysiological consequences of their dysfunctions in vertigo and hearing loss.
An analysis of the acoustic properties of the cell cycle and apoptosis in MCF-7 cells (2013)

Through the use of high frequency acoustic microscopy, the acoustic properties of cells through various stages of interphase (G1/G2), mitosis (metaphase, M-phase) and early apoptosis were ascertained. The cell thickness, sound velocity, acoustic impedance, density, bulk modulus, and attenuation were determined through a quantitative analysis of the pulse echoes from the cell membrane and substrate using a 375 MHz transducer. Hoechst 33342, Annexin-V, propidium iodide and FITC-448 Anti-cyclin B1 and D1 mouse antibodies were used to identify cell cycle stage. ANOVA and Tukey post hoc statistical tests were used to quantify differences between cell stages. A total of 232 cells, 58 within each category, were measured. A statistically significant increase in thickness (9.4 to 11.4 µm), and decrease in attenuation (1.20 to 1.05 dB/cm/MHz) was observed between G1 and G2 cells, respectively. A statistically significant increase in thickness, and decrease in acoustic impedance, density, bulk modulus and attenuation was observed between M-phase and G1 or G2. Significant differences in nearly all properties were observed as the cells progressed to early stage apoptosis from a non-apoptotic state. The differences found indicate considerable structural and/or organizational alterations occurring as the cell progresses thorough these phases.
Surface Immobilization of Transition Metal Ions on Nitrogen‐Doped Graphene Realizing High‐Efficient and Selective CO2 Reduction (2018)

Electrochemical conversion of CO<sub>2</sub> to value-added chemicals using renewable electricity provides a promising way to mitigate both global warming and the energy crisis. Here, a facile ion-adsorption strategy is reported to construct highly active graphene-based catalysts for CO<sub>2</sub> reduction to CO. The isolated transition metal cyclam-like moieties formed upon ion adsorption are found to contribute to the observed improvements. Free from the conventional harsh pyrolysis and acid-leaching procedures, this solution-chemistry strategy is easy to scale up and of general applicability, thus paving a rational avenue for the design of high-efficiency catalysts for CO<sub>2</sub> reduction and beyond.
Synchronous Motor Pull-in Process Analysis (2015)

In this paper, simple approach to analyzing the starting procedure of synchronous motors (SMs) is presented with an emphasis on the pull-in process. Instead of the classical, mostly intuitive pulling-repelling torque approach, an analytical method based on the motor mechanical part swing equation is employed. Factors affecting starting and pull-in processes are clearly indicated and torque impulse balance leading to a pull into step is revealed. It is shown that if the motor fails to pull into step within a single oscillation, it can still be synchronized during one of the succeeding acceleration periods. The crucial role of the excitation winding energizing instant is demonstrated as well. Moreover, the revealed similarity between the SM and phase locked loop (PLL) operations, leads to the conclusion that the algorithms use for analyzing the operation of one may be employed for investigating the other. Experimental results are given to demonstrate the different scenarios, mentioned in the manuscript.
The cAMP binding domain: An ancient signaling module (2004)

cAMP-binding domains from several different proteins were analyzed to determine the properties and interactions of this recognition motif. Systematic computational analyses, including structure-based sequence comparison, surface matching, affinity grid analysis, and analyses of the ligand protein interactions were carried out. These analyses show distinctive roles of the sugar phosphate and the adenine in the cAMP-binding module. We propose that the cAMP-binding regulatory proteins function by providing an allosteric system in which the presence or absence of cAMP produces a substantial structural change through the loss of hydrophobic interactions with the adenine ring and consequent repositioning of the C helix. The modified positioning of the helix in turn is recognized by a protein-binding event, completing the allostery.
Crosstalk is Good: Antenna Design to Enable Polarimetric Compressive Sensing (2022)

Dropped-channel polarimetric synthetic aperture radar (PolSAR) compressed sensing (CS) [1], [2] recovers an unmeasured polarimetric channel by utilizing antenna crosstalk and CS techniques. A sufficient amount of crosstalk is required for successful recovery; however, dual-polarized antennas are typically designed to have very good channel isolation. A new antenna is needed that can provide high crosstalk without sacrificing gain, bandwidth, and radiation pattern. In this paper, we design a new, high crosstalk, dual-polarized patch antenna, using Ansys/HFSS to optimize pin placement and patch size for the desired gain, center frequency, and crosstalk values. The designed antenna is constructed, and S-parameters, gain, and radiation patterns are measured. The measured crosstalk values are then tested in the dropped-channel PolSAR CS model over a few deterministic scenes, demonstrating sufficient expected performance of the physical antenna for sparse scene recovery.
Simulation of a permanent magnet flux-switching machine with reduced outer stator leakage flux (2014)

A small size permanent magnet flux-switching machine is designed with the aim to reduce the undesired leakage flux outside the stator. Different design alternatives are considered using a C-core type permanent magnet flux-switching machine. The leakage flux outside the stator of a permanent magnet flux-switching machine can effectively be reduced by altering the stator structure. To preserve the high torque capability of the flux-switching machine different design modifications of the stator structure have to be applied.
Changes in cardiac biomarkers in association with alterations in cardiac structure and function, and health status in heart failure with reduced ejection fraction: the EVALUATE‐HF trial (2022)

ClinicalTrials.gov Identifier: NCT02874794.