gebhart/patrepeval huggingface dataset:
Innentitelbild: Selective Solid–Liquid and Liquid–Liquid Extraction of Lithium Chloride Using Strapped Calix[4]pyrroles (Angew. Chem. 37/2018) (2018)

Die Abtrennung von LiCl aus einer Mischungvon Alkalimetallchloriden ist eine Herausforderung, gerade im Hinblick auf eine langfristige Lithium-Wiederverwertung und die Behandlung von Rohmaterialien. In ihrer Zuschrift auf S. 12100 nutzen J. L. Sessler, S. K. Kim, B. A. Moyer und Mitarbeiter Calixpyrrol-basierte Ionenpaar-Extraktoren, um LiCl selektiv aus einer festen Mischung von Alkalimetallchloriden zu entfernen. Auch eine selektive Flüssig-flüssig-Extraktion für LiCl wird beschrieben.
Conception et réalisation d'un commutateur et d'un polariseur en optique intégrée sur verre avec un polymère électro-optique (1998)

L'etude de circuits optiques pour des systemes de distribution optiques necessite souvent l'integration de fonctions passives et actives. Actuellement, les materiaux electro-optiques tels que le niobate de lithium et les semi-conducteurs iii-v permettent la realisation de nombreux composants actifs. Malheureusement, la realisation de fonctions passives dans ces materiaux est souvent limitee par des pertes d'insertion elevees et un cout de production excessif. La technologie de l'optique integree sur verre est au contraire plus adaptee pour ce type de fonction mais presente de faibles proprietes non lineaires. Dans ce memoire, nous avons donc etudie et realise des structures hybrides constituees d'un polymere non lineaire depose sur un substrat de verre commercial et passif. Une etude theorique des structures utilisees nous permettent d'envisager des tensions v# de l'ordre de 10 v. Une nouvelle synthese de copolymeres electro-optiques bas-indices, avec des coefficients non lineaires equivalents aux polymeres commerciaux, est presentee pour realiser la structure hybride. Apres avoir choisi les differents materiaux (couche tampon, electrodes superieures et inferieures ) constituant le commutateur, une premiere serie de commutateurs de type sandwich a ete realisee. Des tensions v# de 100 v sur une longueur voisine de 1 cm ont ete mesurees avec des temps de reponse eleves. La realisation d'une electrode transparente plus performante est proposee pour ameliorer ces premiers resultats. De plus, pour optimiser la polarisation a l'entree du composant, un polariseur te integre sur verre constitue du meme polymere birefringent a ete etudie et realise. D'importants taux d'extinction de l'ordre de 40 db et des faibles pertes d'insertion de 7 db ont ete mesures.
Cell-Penetrating Peptides for Antiviral Drug Development (2010)

Viral diseases affect hundreds of millions of people worldwide, and the few available drugs to treat these diseases often come with limitations. The key obstacle to the development of new antiviral agents is their delivery into infected cells <i>in vivo</i>. Cell-penetrating peptides (CPPs) are short peptides that can cross the cellular lipid bilayer with the remarkable capability to shuttle conjugated cargoes into cells. CPPs have been successfully utilized to enhance the cellular uptake and intracellular trafficking of antiviral molecules, and thereby increase the inhibitory activity of potential antiviral proteins and oligonucleotide analogues, both in cultured cells and in animal models. This review will address the notable findings of these studies, highlighting some promising results and discussing the challenges CPP technology has to overcome for further clinical applications.
Quercetin and its principal metabolites, but not myricetin, oppose lipopolysaccharide‐induced hyporesponsiveness of the porcine isolated coronary artery (2010)

Quercetin, quercetin 3'-suphate and quercetin 3-glucuronide, exerted anti-inflammatory effects on the vasculature, possibly through a mechanism involving inhibition of NFκB. Myricetin-induced antagonism of the effect of anti-inflammatory action of quercetin merits further investigation.
U.S Public Policy Toward Network Industries (1996)

This volume shows that the public policy concerns are not accidental, because such industries often embody two major and widely recognized forms of potential market failure.
Biodiversité, reproduction et phylogénie des diatomées bleues du genre Haslea et valorisation de leurs pigments de type marennine (2011)

The diatom Haslea ostrearia has long been considered as the only organism able to produce a blue pigment called marennine, known for greening oysters’ gills in fattening ponds. Key factors for the triggering of this diatom’s sexual reproduction (auxosporulation) have been evidenced, such as cell concentration, light quality or light conditioning. In the aim of a European project, new species of blue diatoms have been discovered : Haslea silbo sp. nov. from the Canary Islands, Haslea karadagensis sp. nov. from the Black Sea and Haslea provincialis sp. nov. from the Mediterranean Sea. A first molecular phylogeny of the genus Haslea has been made using three markers : ITS1-5.8S-ITS2, rbcL and cox1. Blue diatoms appeared to belong to a distinct cluster inside the genus. Availability of two H. ostrearia populations from France and Sweden, sexually compatibles but bearing differences in their cox1 sequences allowed studying the distribution and inheritance of the mitochondrial DNA during auxosporulation. Moreover, UV-visible spectrophotometry and Raman spectometry have been used for pigments’ characterization. Existence of distinct pigments in the newly described species led to the proposal of a chemotaxonomic classification. Finally, biological activities of marennine and H. karadagensis’ pigments have been studied in regards of their antibacterial and antiviral properties.
Using semantic roles to improve summaries (2011)

This paper describes preliminary analysis on the influence of the semantic roles in summary generation. The proposed method involves three steps: first, the named entities in the original text are identified using a named entity recognizer; secondly, the sentences are parsed and semantic roles are extracted; thirdly, selection of the sentences containing specific semantic roles for the most relevant entities in text. Although the method is language independent, in order to check its viability, we tested the proposed approach for Romanian summaries. 1
Diazoacetaldehyde: completion of the rate profile for hydration of its photo-Wolff rearrangement product, ketene, in aqueous solution and kinetics and mechanism of acid-catalyzed hydrolysis of the diazoaldehyde † (1999)

Ketene was generated flash photolytically by the photo-Wolff reaction of diazoacetaldehyde and rates of its hydration to acetic acid were measured in dilute aqueous sodium hydroxide solution. The results give the isotope effect, kHO/kDO = 0.87, on the hydroxide-ion catalytic coefficient for this reaction, and, together with literature information, they provide a complete rate law for the hydration of ketene in aqueous solution promoted by solvent related species: kobs/s–1 = 1.01 × 104[H+] + 3.65 × 101 + 5.26 × 104[HO–]. Rates of hydrolysis of diazoacetaldehyde in dilute perchloric acid solution were also measured and an inverse hydronium ion isotope effect was found: kH+/kD+ = 0.55. That, plus the fact that hydrogen exchange of the diazo hydrogen atom of diazoacetaldehyde takes place more rapidly than its hydrolysis, shows that hydrolysis occurs through a mechanism involving pre-equilibrium protonation of diazo carbon followed by rate-determining loss of nitrogen.
Drilling and completing multiple branched boreholes for in-situ leach mining (1981)

Multiple branch wells contain two or more boreholes drilled from a single vertical hole and can reduce drilling costs by reducing total footage drilled. Completing this type of well requires new technology, such as covered in the paper.
Phosphorylation of FADD by the kinase CK1α promotes KRAS G12D -induced lung cancer (2015)

Genomic amplification of the gene encoding and phosphorylation of the protein FADD (Fas-associated death domain) is associated with poor clinical outcome in lung cancer and in head and neck cancer. Activating mutations in the guanosine triphosphatase RAS promotes cell proliferation in various cancers. Increased abundance of phosphorylated FADD in patient-derived tumor samples predicts poor clinical outcome. Using immunohistochemistry analysis and in vivo imaging of conditional mouse models of KRAS(G12D)-driven lung cancer, we found that the deletion of the gene encoding FADD suppressed tumor growth, reduced the proliferative index of cells, and decreased the activation of downstream effectors of the RAS-MAPK (mitogen-activated protein kinase) pathway that promote the cell cycle, including retinoblastoma (RB) and cyclin D1. In mouse embryonic fibroblasts, the induction of mitosis upon activation of KRAS required FADD and the phosphorylation of FADD by CK1α (casein kinase 1α). Deleting the gene encoding CK1α in KRAS mutant mice abrogated the phosphorylation of FADD and suppressed lung cancer development. Phosphorylated FADD was most abundant during the G2/M phase of the cell cycle, and mass spectrometry revealed that phosphorylated FADD interacted with kinases that mediate the G2/M transition, including PLK1 (Polo-like kinase 1), AURKA (Aurora kinase A), and BUB1 (budding uninhibited by benzimidazoles 1). This interaction was decreased in cells treated with a CKI-7, a CK1α inhibitor. Therefore, as the kinase that phosphorylates FADD downstream of RAS, CK1α may be a therapeutic target for KRAS-driven lung cancer.
ChemInform Abstract: Nickel‐Catalyzed Cross‐Couplings of Alkenyl and α‐Metalated Alkenyl Sulfoximines with Organometallics: Stereoselective Synthesis of Carbacyclins. (1989)

Abstract The exocyclic alkenes (III), ultimate precursors for carbacyclins, are prepared in an E‐selective synthesis from the alkenylsulfoxime (I) by Ni‐catalyzed cross‐coupling with the diorganozincs (II).
Kinectrack: Agile 6-DoF tracking using a projected dot pattern (2012)

We present Kinectrack, a new six degree-of-freedom (6-DoF) tracker which allows real-time and low-cost pose estimation using only commodity hardware. We decouple the dot pattern emitter and IR camera of the Kinect. Keeping the camera fixed and moving the IR emitter in the environment, we recover the 6-DoF pose of the emitter by matching the observed dot pattern in the field-of-view of the camera to a pre-captured reference image. We propose a novel matching technique to obtain dot pattern correspondences efficiently in wide- and adaptive-baseline scenarios. We also propose an auto-calibration method to obtain the camera intrinsics and dot pattern reference image. The performance of Kinectrack is evaluated and the rotational and translational accuracy of the system is measured relative to ground truth for both planar and multi-planar scene geometry. Our system can simultaneously recover the 6-DoF pose of the device and also recover piecewise planar 3D scene structure, and can be used as a low-cost method for tracking a device without any on-board computation, with small size and only simple electronics.
Biocatalytic Racemization of Aliphatic, Arylaliphatic, and Aromatic α-Hydroxycarboxylic Acids (2005)

[reaction: see text] Biocatalytic racemization of a range of aliphatic, (aryl)aliphatic, and aromatic alpha-hydroxycarboxylic acids was accomplished by using whole resting cells of a range of Lactobacillus spp. The mild (physiological) reaction conditions ensured an essentially "clean" isomerization in the absence of side reactions, such as elimination or decomposition. Whereas straight-chain aliphatic 2-hydroxycarboxylic acids were racemized with excellent rates (up to 85% relative to lactate), steric hindrance was observed for branched-chain analogues. Good rates were observed for aryl-alkyl derivatives, such as 3-phenyllactic acid (up to 59%) and 4-phenyl-2-hydroxybutanoic acid (up to 47%). In addition, also mandelate and its o-chloro analogue were accepted at a fair rate (45%). This biocatalytic racemization represents an important tool for the deracemization of a number of pharmaceutically important building blocks.
A Molecular Cryptosystem for Images by DNA Computing (2012)

Cracking the encryption: Parallel computing with molecular finite-state automata and fluorescently labeled DNA molecules has been used to decipher two different images encrypted onto a single DNA chip (see picture). The images were deciphered by a mixture of input molecules that were processed by biomolecular automata, a strategy that potentially offers a huge diversity of encrypted images.
Prosthodontic decision‐making relating to dentitions with compromised molars: the perspective of Swedish General Dental Practitioners (2016)

The aim of this investigation was to study the clinical prosthodontic decision-making process relating to dentitions with compromised molars among Swedish general dental practitioners (GDPs). Eleven Swedish GDPs were purposively selected, and all agreed to participate. Then, in-depth, semi-structured interviews were conducted and covered treatment considerations concerning two authentic patient cases, initially with complete dental arches, and later, a final treatment based on a shortened dental arch (SDA) was discussed. The cases involved patients with compromised teeth situated mainly in the molar regions. One patient suffered from extensive caries and the other from severe periodontal disease. Qualitative content analysis was used to analyse the data. In the systematic analysis, two main categories were identified: holistic and functional approach. Among the interviewed GDPs, focus was put on patients' needs, background history and motivation for treatment as well as the preservation of molar support. Within the limitations of this study, the following can be concluded: keeping a dental arch with molars seems to be important to Swedish general dental practitioners. The SDA concept does not seem to have a substantial impact on the prosthodontic decision-making relating to dentitions with compromised molars. The dentist's experiences, as well as colleagues' or consulting specialist advice together with aetiological factors and the patient's individual situation, influence the decision-making more than the SDA concept. The conflicting results in the prosthetic decision-making process concerning the relevance of age and the need for molar support need further investigation, for example based on decisions made in the dentist's own clinical practice.
Colloidal Nanoparticles (2019)

This book will focus on synthesis, coating and functionalization chemistry of selected nanoparticles that are most commonly used in various biomedical applications. Apart from standard selected chemical synthetic methods, it focusses on design consideration of functionalization, selected coating chemistry for transforming as synthesized nanoparticle, selected conjugation chemistries and purification approach for such nanoparticles. It also includes state-of-art/future prospect of nanodrugs suitable for clinical applications. There will material on general application potential of these nanoparticles, importance of functionalization and common problems faced by non-chemists.
Biochemical and immunological characterization of an ETEC CFA/I adhesin cholera toxin B subunit chimera (2020)

Surface-expressed colonization factors and their subunits are promising candidates for inclusion into a multivalent vaccine targeting enterotoxigenic Escherichia coli (ETEC), a leading cause of acute bacterial diarrhea in developing regions. However, soluble antigens are often poorly immunogenic in the absence of an adjuvant. We show here that the serum immune response to CfaE, the adhesin of the ETEC colonization factor CFA/I, can be enhanced in BALB/c mice by immunization with a chimeric antigen containing CfaE and pentameric cholera toxin B subunit (CTB) of cholera toxin from Vibrio cholerae. We constructed this antigen by replacing the coding sequence for the A1 domain of the cholera toxin A subunit (CTA) with the sequence of donor strand complemented CfaE (dscCfaE) within the cholera toxin operon, resulting in a dscCfaE-CTA2 fusion. After expression, via non-covalent interactions between CTA2 and CTB, the fusion and CTB polypeptides assemble into a complex containing a single dscCfaE-CTA2 protein bound to pentameric CTB (dscCfaE-CTA2/CTB). This holotoxin-like chimera retained the GM1 ganglioside binding activity of CTB, as well as the ability of CfaE to mediate the agglutination of bovine red blood cells when adsorbed to polystyrene beads. When administered intranasally to mice, the presence of CTB in the chimera significantly increased the serum immune response to CfaE compared to dscCfaE alone, stimulating a response similar to that obtained with a matched admixture of dscCfaE and CTB. However, by the orogastric route, immunization with the chimera elicited a superior functional immune response compared to an equivalent admixture of dscCfaE and CTB, supporting further investigation of the chimera as an ETEC vaccine candidate.
Supplementary Table 1 from Endoglin (CD105) Contributes to Platinum Resistance and Is A Target for Tumor-Specific Therapy in Epithelial Ovarian Cancer (2023)

&lt;p&gt;PDF file - 72K, QPCR array for DNA Damage genes after endoglin downregulation&lt;/p&gt;
The effectiveness of essential-state models in the description of optical properties of branched push–pull chromophores (2010)

In this paper we present the synthesis, spectroscopic characterization and theoretical modelling of two pairs of correlated dipolar and octupolar donor-acceptor conjugated chromophores, based on the triphenylamine branching centre. The two pairs of chromophores differ for the electron withdrawing end-groups. Linear absorption, fluorescence and two-photon absorption of all the compounds in different solvents can be well described by the use of charge-resonance theoretical models based on essential-state descriptions of the electronic structure, and taking into account the coupling to effective molecular vibrations and to polar solvation degrees of freedom. On the contrary, the alternative Frenkel exciton model does not provide a good description of the observed behavior. The robustness of the proposed theoretical models is demonstrated for the first time by the fact that the modulation of a single molecular parameter (the one linked to the electron-withdrawing ability of the end groups) is enough to describe the evolution of the spectroscopic properties along the whole series of chromophores, both "intra-pair" and "inter-pair". The effectiveness of the approach suggests that this kind of theoretical modelling can be very useful to predict different properties of the compounds at hand or of correlated structures of increasing complexity, such as dendrons and dendrimers, giving a guide to the synthesis of (macro)molecules for applications in light-emitting and nonlinear optical devices, artificial light-harvesting systems or optical imaging of living tissues.
Television and Religion: The Shaping of Faith, Values, and Culture. By William F. Fore. Minneapolis, Minn.: Augsburg Publishing House, 1987. $11.95 (1988)

Journal Article Television and Religion: The Shaping of Faith, Values, and Culture. By William F. Fore. Minneapolis, Minn.: Augsburg Publishing House, 1987. $11.95 Get access Michael Korpi Michael Korpi Baylor UniversityWaco, Texas Search for other works by this author on: Oxford Academic Google Scholar Journal of Church and State, Volume 30, Issue 3, Autumn 1988, Pages 602–603, https://doi.org/10.1093/jcs/30.3.602 Published: 01 October 1988
Rheostats and Toggle Switches for Modulating Protein Function (2013)

The millions of protein sequences generated by genomics are expected to transform protein engineering and personalized medicine. To achieve these goals, tools for predicting outcomes of amino acid changes must be improved. Currently, advances are hampered by insufficient experimental data about nonconserved amino acid positions. Since the property "nonconserved" is identified using a sequence alignment, we designed experiments to recapitulate that context: Mutagenesis and functional characterization was carried out in 15 LacI/GalR homologs (rows) at 12 nonconserved positions (columns). Multiple substitutions were made at each position, to reveal how various amino acids of a nonconserved column were tolerated in each protein row. Results showed that amino acid preferences of nonconserved positions were highly context-dependent, had few correlations with physico-chemical similarities, and were not predictable from their occurrence in natural LacI/GalR sequences. Further, unlike the "toggle switch" behaviors of conserved positions, substitutions at nonconserved positions could be rank-ordered to show a "rheostatic", progressive effect on function that spanned several orders of magnitude. Comparisons to various sequence analyses suggested that conserved and strongly co-evolving positions act as functional toggles, whereas other important, nonconserved positions serve as rheostats for modifying protein function. Both the presence of rheostat positions and the sequence analysis strategy appear to be generalizable to other protein families and should be considered when engineering protein modifications or predicting the impact of protein polymorphisms.
Al@TiO2 Core–Shell Nanoparticles for Plasmonic Photocatalysis (2022)

Plasmon-induced photocatalysis is a topic of rapidly increasing interest, due to its potential for substantially lowering reaction barriers and temperatures and for increasing the selectivity of chemical reactions. Of particular interest for plasmonic photocatalysis are antenna-reactor nanoparticles and nanostructures, which combine the strong light-coupling of plasmonic nanostructures with reactors that enhance chemical specificity. Here, we introduce Al@TiO<sub>2</sub> core-shell nanoparticles, combining earth-abundant Al nanocrystalline cores with TiO<sub>2</sub> layers of tunable thickness. We show that these nanoparticles are active photocatalysts for the hot electron-mediated H<sub>2</sub> dissociation reaction as well as for hot hole-mediated methanol dehydration. The wavelength dependence of the reaction rates suggests that the photocatalytic mechanism is plasmonic hot carrier generation with subsequent transfer of the hot carriers into the TiO<sub>2</sub> layer. The Al@TiO<sub>2</sub> antenna-reactor provides an earth-abundant solution for the future design of visible-light-driven plasmonic photocatalysts.
SINGULAR VALUE DECOMPOSITION REGRESSION MODELS FOR CLASSIFICATION OF TUMORS FROM MICROARRAY EXPERIMENTS (2001)

An important problem in the analysis of microarray data is correlating the high-dimensional measurements with clinical phenotypes. In this paper, we develop predictive models for associating gene expression data from microarray experiments with such outcomes. They are based on the singular value decomposition. We propose new algorithms for performing gene selection and gene clustering based on these predictive models. The estimation procedure using the regression models occurs in two stages. First, the gene expression measurements are transformed using the singular value decomposition. The regression parameters in the model linking the principal components with the clinical responses are then estimated using maximum likelihood. We demonstrate the application of the methodology to data from a breast cancer study.