gebhart/patrepeval huggingface dataset:
Task-dependent Alteration in Delta Band Corticomuscular Coherence during Standing in Chronic Stroke Survivors (2023)

Balance control is an important indicator of mobility and independence in activities of daily living. How the changes in functional integrity of corticospinal tract due to stroke affects the maintenance of upright stance remains to be known. We investigated the changes in functional coupling between the cortex and lower limb muscles during a challenging balance task over multiple frequency bands in chronic stroke survivors. Eleven stroke patients and nine healthy controls performed a challenging balance task. They stood on a computerized platform with/without somatosensory input distortion created by sway-referencing the support surface, thereby varying the difficulty levels of the task. We computed corticomuscular coherence between Cz (electroencephalography) and leg muscles and assessed balance performance using Berg Balance scale (BBS), Timed-up and go (TUG) and center of pressure (COP) measures. We found lower delta frequency band coherence in stroke patients when compared with healthy controls under medium difficulty condition for distal but not proximal leg muscles. For both groups, we found similar coherence at other frequency bands. On BBS and TUG, stroke patients showed poor balance. However, similar group differences were not consistently observed across COP measures. The presence of distal versus proximal effect suggests differences in the (re)organization of the corticospinal connections across the two muscles groups for balance control. We argue that the observed group difference in the delta coherence might be due to altered mechanisms for the detection of somatosensory modulation resulting from sway-referencing of the support platform for balance control.
Zusammenfassung (1978)

Im Rahmen des durchgeführten Forschungsvorhabens wurden die Möglichkeiten für den Bau von Großnaturzugkühltürmen untersucht. Dabei wurden rotationssymmetrische Konstruktionen mit negativer GAUSSscher Krümmung, zum einen mit unmittelbar tragender Haut und zum anderen mit mittelbar tragender Haut berücksichtigt.
Discovery of a Brigatinib Degrader SIAIS164018 with Destroying Metastasis-Related Oncoproteins and a Reshuffling Kinome Profile (2021)

Proteolysis-targeting chimera (PROTAC) is an attractive technology in drug discovery. Canonically, targets act as a basic starting point in the most previous PROTAC design. Here, we designed degraders considering from the view of clinical benefits. With this novel design, Brigatinib was turned into a degrader SIAIS164018 and endowed with unique features. First, SIAIS164018 could degrade not only ALK fusion proteins in activating or G1202R-mutated form but also mutant EGFR with L858R + T790M, which are two most important targets in non-small-cell lung cancer. Second, SIAIS164018 strongly inhibited cell migration and invasion of Calu-1 and MDA-MB-231. Third and surprisingly, SIAIS164018 degrades several important oncoproteins involved in metastasis such as FAK, PYK2, and PTK6. Interestingly, SIAIS164018 reshuffled the kinome ranking profile when compared to Brigatinib. Finally, SIAIS164018 is orally bioavailable and well tolerated in vivo. SIAIS164018 is an enlightening degrader for us to excavate the charm of protein degradation.
Effects of roughness and resonant‐mode engineering in all‐dielectric metasurfaces (2020)

Abstract The development of all‐dielectric metasurfaces vigorously prompts the applications of optical metasurfaces for the visible and near‐IR light range. Compared to IR or longer wavelength light, visible and near‐IR light have shorter wavelengths. As a result, surface roughness and imperfections of all‐dielectric metasurfaces have larger scattering or absorption of visible and near‐IR light, thereby directly affecting the performance of an all‐dielectric metasurface. In this article, a volume‐current method is adopted to study the effect of metasurface roughness. Numerical calculations based on the finite difference time domain (FDTD) method are also used to study the relationship between the effects of metasurface roughness and the optical resonant modes. Numerical predictions based on our theoretical studies fit the experimental data well. Further, the effect of different roughness levels on the all‐dielectric metasurface performance is predicted. More importantly, a method utilizing resonant‐mode engineering to enhance the metasurface performance (e.g. incident angle insensitivity) is also proposed and demonstrated. This work deepens our understanding of the working mechanism of all‐dielectric metasurfaces and paves the way for their use in a broad spectrum of applications.
[Ultrasonic diagnosis of retinal detachment after internal tamponade with silicone oil]. (1998)

The authors evaluate the results of ultrasound examination of 20 patients with retinal detachment (20 eyes) after pars plana vitrectomy with silicone oil tamponade. Ultrasound diagnostic method is necessary in cases with non-transparent optic media. Silicone oil in the space of vitreous cavity has a character of a swimming water-drop and his physical properties can change the echography results. Between the eye-wall and silicone oil is a virtual space, which could be well visualised by ultrasound. The patients are divided into 2 groups. In the 1st group there were 7 eyes with transparent optic media and retina was detached under the silicone oil. By ultrasound the retina detachment echo was localised between the echos of silicone oil and eye wall. In the 2nd group there were 13 eyes with non-transparent optic media. In 6 cases (41.6%) the retinal detachment echo was visualised. The retinal detachment was confirmed by vitreo-retinal surgery.
Comparison of Organic to Some Conventional Insecticides for Control of Asian Citrus Psyllid and Citrus Leafminer on Oranges, Spring 2014 (2015)

ACP is the key pest of Florida citrus due to its role as vector of greening disease or “huanglongbing.” Feeding damage from CLM larvae facilitates spread of citrus canker caused by Xanthomonas axonopodis pv. citri . Organic citrus growers have few proven alternatives for controlling these pests, providing the motive for this trial. The experimental block located at a commercial grove near Labelle, FL, consisted of 12-yr-old “Hamlin” sweet orange planted at a density of 132 trees per acre. Ten treatments and an untreated check were randomly distributed in an RCBD with four replicates in five-tree plots over four rows with one untreated buffer row between treated rows and one untreated buffer tree between plots …
ChemInform Abstract: Suzuki—Miyaura Coupling Reactions of Conjunctive Reagents: 2‐Borylated Allylic Sulfones. (2015)

Abstract Methods for the Suzuki‐Miyaura coupling of borylated allylic sulfones with electrophiles in both the inter‐ and the less common intramolecular modes are developed.
ShanghaiMart Review in 2007 (2007)

2007 VIFF Design Club Activities Recently, the 2007 VIFF Design Club Activities,organized by the View International Fashion & Fabrics
Preventable Cancer Burden Associated With Poor Diet in the United States (2019)

More than 80 000 new cancer cases are estimated to be associated with suboptimal diet among US adults in 2015, with middle-aged men and racial/ethnic minorities experiencing the largest proportion of diet-associated cancer burden in the United States.
Nicotine Exacerbates TAAD Formation Induced by Smooth Muscle-Specific Deletion of the TGF-β Receptor 2 (2021)

Tobacco smoke is an established risk factor for thoracic aortic aneurysms and dissections (TAAD). However, little is known about its underlying mechanisms due to the lack of validated animal models. The present study developed a mouse model that may be utilized to investigate exacerbation of TAAD formation by mimetics of tobacco smoke. TAADs were created via inducible deletion of smooth muscle cell-specific <i>Tgfbr2</i> receptors. Using this model, the first set of experiments evaluated the efficacy of nicotine salt (34.0 mg/kg/day), nicotine free base (NFB, 5.0 mg 90-day pellets), and cigarette smoke extract (0.1 ml/mouse/day). Compared with their respective control groups, only NFB pellets promoted TAAD dilation (23 ± 3% vs. 12 ± 2%, <i>P</i> = 0.014), and this efficacy was achieved at a cost of >50% acute mortality. Infusion of NFB with osmotic minipumps at extremely high, but nonlethal, doses (15.0 or 45.0 mg/kg/day) failed to accelerate TAAD dilation. Interestingly, costimulation with <i>β</i>-aminopropionitrile (BAPN) promoted TAAD dilation and aortic rupture at dosages of 3.0 and 45.0 mg/kg/day, respectively, indicating that BAPN sensitizes the response of TAADs to NFB. In subsequent analyses, the detrimental effects of NFB were associated with clustering of macrophages, neutrophils, and T-cells in areas with structural destruction, enhanced matrix metalloproteinase- (MMP-) 2 production, and pathological angiogenesis with attenuated fibrosis in the adventitia. In conclusion, modeling nicotine exacerbation of TAAD formation requires optimization of chemical form, route of delivery, and dosage of the drug as well as the pathologic complexity of TAADs. Under the optimized conditions of the present study, chronic inflammation and adventitial mal-remodeling serve as critical pathways through which NFB exacerbates TAAD formation.
Rapid Identification of Candida glabrata with a New Commercial Test, GLABRATA RTT (2003)

The GLABRATA RTT test (Fumouze Diagnostics, Levallois Perret, France) is based on the ability of Candida glabrata to hydrolyze trehalose but not maltose. It requires an inoculum of only four to six colonies, and the results are available within 20 min. We tested GLABRATA RTT with 330 stock isolates grown in subcultures on four different primary fungal isolation media and obtained a sensitivity of 94 to 98% (depending on the medium used) and a specificity of 97.3 to 98.6%. The false-positive results corresponded to C. tropicalis, C. famata, and C. lusitaniae. GLABRATA RTT thus offers rapid and reliable identification of C. glabrata.
Low-temperature ion beam enhanced etching of tungsten films with xenon difluoride (1986)

The spontaneous and ion enhanced etching of sputter deposited tungsten films has been studied. The etch rates have been measured as a function of various etch parameters with striking differences found as a function of sample temperatures. The spontaneous etch rate is found to be totally suppressed at temperatures below 170 K, and concomitantly the ion enhanced etch rate is increased. With these two points in mind, it is shown that ion beam enhanced etching of W with XeF2 at moderately low temperatures could be used to greatly improve the ratio of the ion enhanced etch rate over the spontaneous etch rate. This unique condition could be used to achieve high aspect ratio structures with vertical walls and opens up the possibility of direct ion beam pattern definition.
DNA Sequence Requirements for Replication of Polyomavirus DNA In Vivo and In Vitro (1987)

Cell extracts of FM3A mouse cells replicate polyomavirus (Py) DNA in the presence of immunoaffinity-purified Py large T antigen, deoxynucleoside triphosphates, ATP, and an ATP-generating system. This system was used to examine the effects of mutations within or adjacent to the Py core origin (ori) region in vitro. The analysis of plasmid DNAs containing deletions within the early-gene side of the Py core ori indicated that sequences between nucleotides 41 and 57 define the early boundary of Py DNA replication in vitro. This is consistent with previously published studies on the early-region sequence requirements for Py replication in vivo. Deleting portions of the T-antigen high-affinity binding sites A and B (between nucleotides 57 and 146) on the early-gene side of the core ori led to increased levels of replication in vitro and to normal levels of replication in vivo. Point mutations within the core ori region that abolish Py DNA replication in vivo also reduced replication in vitro. A mutant with a reversed orientation of the Py core ori region replicated in vitro, but to a lesser extent that wild-type Py DNA. Plasmids with deletions on the late-gene side of the core ori, within the enhancer region, that either greatly reduced or virtually abolished Py DNA replication in vivo replicated to levels similar to those of wild-type Py DNA plasmids in vitro. Thus, as has been observed with simian virus 40, DNA sequences needed for Py replication in vivo are different from and more stringent than those required in vitro.
In Operando and Local Estimation of the Effective Humidity of PEMFC Electrodes and Membranes (2017)

International audience
Stress polishing demonstrator for ELT M1 segments and industrialization (2014)

After two years of research and development under ESO support, LAM and Thales SESO present the results of their experiment for the fast and accurate polishing under stress of ELT 1.5 meter segments as well as the industrialization approach for mass production. Based on stress polishing, this manufacturing method requires the conception of a warping harness able to generate extremely accurate bending of the optical surface of the segments during the polishing. The conception of the warping harness is based on finite element analysis and allowed a fine tuning of each geometrical parameter of the system in order to fit an error budget of 25nm RMS over 300μm of bending peak to valley. The optimisation approach uses the simulated influence functions to extract the system eigenmodes and characterise the performance. The same approach is used for the full characterisation of the system itself. The warping harness has been manufactured, integrated and assembled with the Zerodur 1.5 meter segment on the LAM 2.5meter POLARIS polishing facility. The experiment consists in a cross check of optical and mechanical measurements of the mirrors bending in order to develop a blind process, ie to bypass the optical measurement during the final industrial process. This article describes the optical and mechanical measurements, the influence functions and eigenmodes of the system and the full performance characterisation of the warping harness.
Synthesis of aldehyde and carboxylic acid derivatives from 2‐hydroxymethyl‐3‐hydroxy‐4H‐pyran‐4‐one (α‐hydroxymaltol) (1986)

Abstract α‐Hydroxymaltol (2‐hydroxymethyl‐3‐hydroxy‐4 H ‐pyran‐4‐one) ( 1 ) has been converted to the 3‐ O ‐methyl ether 2 and 3‐ O‐p ‐nitrobenzyl ether 4 by standard methods. The ethers 2 and 4 have been oxidized by barium manganate to the corresponding aldehydes, 3 and 5 , in 91 and 77% yields respectively. Long‐term reaction of 5 with hydrogen bromide in acetic acid gives 3‐hydroxy‐4 H ‐pyran‐4‐one‐2‐carboxaldehyde ( 6 ). The aldehyde 3 is readily oxidized by short‐term reaction with silver oxide to the corresponding acid 7 .
Large-Scale Biomedical Science (2003)

The nature of biomedical research has been evolving in recent years. Technological advances that make it easier to study the vast complexity of biological systems have led to the initiation of projects with a larger scale and scope. In many cases, these large-scale analyses may be the most efficient and effective way to extract functional information from complex biological systems.

Large-Scale Biomedical Science: Exploring Strategies for Research looks at the role of these new large-scale projects in the biomedical sciences. Though written by the National Academies Cancer Policy Board, this book addresses implications of large-scale science extending far beyond cancer research. It also identifies obstacles to the implementation of these projects, and makes recommendations to improve the process. The ultimate goal of biomedical research is to advance knowledge and provide useful innovations to society. Determining the best and most efficient method for accomplishing that goal, however, is a continuing and evolving challenge. The recommendations presented in Large-Scale Biomedical Science are intended to facilitate a more open, inclusive, and accountable approach to large-scale biomedical research, which in turn will maximize progress in understanding and controlling human disease.
Re2O7-catalyzed reaction of hemiacetals and aldehydes with O-, S-, and C-nucleophiles (2013)

Re(VII) oxides catalyze the acetalization, monoperoxyacetalization, monothioacetalization and allylation of hemiacetals. The reactions, which take place under mild conditions and at low catalyst loadings, can be conducted using hemiacetals, the corresponding O-silyl ethers, and, in some cases, the acetal dimers. Aldehydes react under similar conditions to furnish good yields of dithioacetals. Reactions of hemiacetals with nitrogen nucleophiles are unsuccessful. 1,2-Dioxolan-3-ols (peroxyhemiacetals) undergo Re(VII)-promoted etherification but not allylation. Hydroperoxyacetals (1-alkoxyhydroperoxides) undergo selective exchange of the alkoxide group in the presence of either Re2O7 or a Brønsted acid.
Kinetics and Mechanism of NaOH-Impregnated Calcined Oyster Shell-Catalyzed Transesterification of Soybean Oil (2017)

The objective of this research is to develop a kinetic model to describe the transesterification of soybean oil with methanol using NaOH-impregnated calcined oyster shell (Na-COS). Batch experiments were performed via a two-factor randomized complete block design using a molar ratio of methanol to oil (MR) of 6, 12, and 18 and catalyst loadings (CL) (mass of catalyst/mass of oil in %) of 2%, 4%, 6%, and 8% to obtain fatty acid methyl ester yields. In addition, the catalyst was studied by X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and time-of-flight secondary ion spectrometry (TOF-SIMS) to elucidate the role of the catalyst in the transesterification reaction. XRD and XPS analyses suggested that the formation of sodium peroxide (Na2O2) on the surface contributed to catalytic activity. The TOF-SIMS analysis suggested that the transesterification occurred between adsorbed triglyceride and free methanol, similar to the Eley-Rideal mechanism. The transesterification of adsorbed triglyceride to adsorbed diglyceride was found to be the rate-determining step with a rate constant of 0.0059 ± 0.0002 L mol−1 min−1.
Selection, performance and economic evaluation of dust palliatives on surface mine haul roads (2007)

Excessive dust generation from unpaved mine haul roads is a problem common to most surface mining operations. While optimal road wearing course material selection parameters reduce the inherent dust generation potential, they do not totally eliminate fugitive dust. Many different classes of suppression or palliative treatments are available for mine haul roads and this paper initially ascertains basic selection guidelines, using a set of ideal dust palliative product, application and performance parameters based on mine road-user requirements. An evaluation and modelling methodology for truck generated fugitive dust emissions is developed as a basis for the comparative assessment of dust control strategies. For water-based spraying, a watering model was developed to estimate individual mine road watering frequencies for characteristic site parameter combinations during summer and winter operating conditions, for a required level of control or maximum dust defect. This forms the base-case scenario with which to compare the performance of other types of dust palliatives under the same conditions.Finally, a basic palliative economic evaluation model is introduced with the aim of identifying and costing the establishment, application and maintenance rejuvenation activities associated with the use of chemical palliatives. While palliative cost and performance is generally site specific, it is shown that under certain combinations of conditions, the use of dust palliatives has the potential to deliver cost savings when compared to water-based spraying.
The role of PtdIns(4,5)P2 in exocytotic membrane fusion (1997)

Conference Article| November 01 1997 The role of PtdIns(4,5)P2 in exocytotic membrane fusion T. F. J. Martin; T. F. J. Martin 1 1Department of Biochemistry, University of Wisconsin, 420 Henry Mall, Madison, WI 53706, U.S.A. 1To whom correspondence should be addressed Search for other works by this author on: This Site PubMed Google Scholar K. M. Loyet; K. M. Loyet 1Department of Biochemistry, University of Wisconsin, 420 Henry Mall, Madison, WI 53706, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar V. A. Barry; V. A. Barry 1Department of Biochemistry, University of Wisconsin, 420 Henry Mall, Madison, WI 53706, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar J. A. Kowalchyk J. A. Kowalchyk 1Department of Biochemistry, University of Wisconsin, 420 Henry Mall, Madison, WI 53706, U.S.A. Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Received: July 09 1997 Online ISSN: 1470-8752 Print ISSN: 0300-5127 © 1997 Biochemical Society1997 Biochem Soc Trans (1997) 25 (4): 1137–1141. https://doi.org/10.1042/bst0251137 Article history Received: July 09 1997 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation T. F. J. Martin, K. M. Loyet, V. A. Barry, J. A. Kowalchyk; The role of PtdIns(4,5)P2 in exocytotic membrane fusion. Biochem Soc Trans 1 November 1997; 25 (4): 1137–1141. doi: https://doi.org/10.1042/bst0251137 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1997 Biochemical Society1997 Article PDF first page preview Close Modal You do not currently have access to this content.
PT-symmetry breaking of topological defect-states in SSH micro-ring laser arrays (2017)

The PT-symmetry breaking for topological defect-states are studied in SSH micro-resonator laser arrays. For defect modes, the PT-symmetry breaking threshold reduces when the coupling strength between closely paired elements is increased. Such topological defect-modes are demonstrated in a 16-ring SSH PT-laser arrangement.
Conversion Kinetics of Silicate, Borosilicate, and Borate Bioactive Glasses to Hydroxyapatite (2009)

Bioactive 45S5 glass has been studied extensively both in vivo and in vitro, and it is relatively well known that when placed in a phosphate containing solution the glass will react to form the bone-like material hydroxyapatite (HA). In the present work, a kinetic analysis of previously measured weight loss data was done to determine reaction rate constants for four bioactive glasses; one silicate glass, two borosilicate glasses, and one borate glass, via the contracting volume model. The reaction rate increased with increasing B(2)O(3) content., with the borate glass reacting nearly five times faster than the silicate 45S5 glass. The three silica containing glasses all deviated from the contracting volume model after approximately 50-70% of the total weight loss; however, when compared to the 3D diffusion model, the normalised data were in good agreement to 100% of the total weight loss. The deviation from the contracting volume model to the slower 3D diffusion model indicates a change in conversion model for the silica containing glasses and can likely be attributed to the formation of a silica rich layer of a certain thickness that began controlling the release of ions from the unreacted glass by diffusion.
Interfacial Forces and Interfaces in Hard Biomaterial Mechanics (2012)

This chapter contains sections titled: Introduction Hard Biological Materials Bioengineering and Biomimetics Summary References