gebhart/patrepeval huggingface dataset:
Fabrication of highly conductive graphene particle‐coated fiber yarns using polymeric binders through efficient coating techniques (2018)

Abstract Electrically conductive yarns have been produced by fabricating graphene particles (both graphene nanoplatelets and reduced graphene oxide) on glass, flax, and polypropylene yarns using binding materials (epoxy resin and thermoplastic starch solution) and a dip coating process. Three different dip coating processes have been developed to identify an efficient method of coating in terms of improving electrical conductivity. Morphological study has been carried out to understand the mechanism at the interphase between binder and conductive particles, and it has been found that Van der Waals force and adhesive bonding are higher with epoxy‐based samples than those of starch‐based. Glass fiber yarns (with epoxy binder and rGO/GNP) have been identified as having the highest electrical conductivity of 0.1 S/cm.
Design on topologies for high efficiency two-stage AC-DC converter (2012)

Design on topologies for high efficiency 60W level two-stage AC-DC adapter is proposed in this paper. Conventional 60W level single-stage AC-DC converter has wide input range. And flyback topology has low efficiency characteristic. Therefore, conventional 60W single-stage AC-DC adapter has low efficiency characteristic. In order to develop small and high efficiency AC-DC converter, propose two-stage AC-DC converter structure. Two-stage AC-DC converter is added PFC stage. But DC-DC stage easy to design Because input voltage fixed link capacitor voltage. Moreover, size of input-filter decrease due to PFC stage effect. Therefore, two-stage AC-DC converter has high efficiency. And it is possible to put in conventional single-stage AC-DC adapter case. Design procedures and experimental results for boost PFC, flyback, forward and LLC DC-DC converters are presented to select the suitable topologies of two-stage AC-DC converter.
Seasonality and personality: a prospective investigation of Five Factor Model correlates of mood seasonality (2002)

The aim of the present study was to explore winter pattern seasonality of mood by investigating its Five Factor Model (FFM) correlates. The study was an advance on existing research in that seasonality was measured not as a retrospective self‐description of mood variation, but as a prospective pattern of current mood states in winter and summer (across two years). Based on contemporary theorizing about the structure and function of mood, Positive Affect (PA) was the mood construct selected for measurement. A seasonality score was calculated for each participant as the difference between summer mood levels and winter mood levels. The NEO‐FFI was administered at all four waves. Three hundred and three respondents from a random community sample in Melbourne, Australia, provided complete data. Regression analyses found that the adaptive trait Openness to Experience (O) was specifically associated with the tendency towards lowered mood in winter relative to summer. The vulnerability trait Neuroticism (N) was not a directional predictor of winter pattern seasonality, but was the sole predictor of absolute seasonality score. Findings are discussed in terms of two affective processes that may be involved in mood variation across the seasonal time frame: adaptive environmental sensitivity and endogenous mood variability. Copyright © 2002 John Wiley &amp; Sons, Ltd.
Phase IB trial of ACY-1215 (Ricolinostat) combined with nab-paclitaxel in metastatic breast cancer. (2018)

1058 Background: HDAC6, a cytoplasmic histone deacetylase, plays an important role in cell-cell interactions, motility, chaperone function, and protein degradation. ACY-1215 is an orally active, selective HDAC6 inhibitor. Preclinical studies have demonstrated ACY-1215 to have synergistic activity with taxanes. We have developed an algorithm (HDAC6 score) based on mRNA expression profiling to evaluate the HDAC6 activity of individual tumor samples. Methods: In this open-label phase Ib, patients (pts) received ACY-1215 daily for 21 days of each 28-day cycle with nab-paclitaxel 100 mg/m2 on days 1, 8, and 15 until progression of disease or unacceptable toxicity. The primary objective was to establish the maximum tolerated dose of ACY-1215 with nab-paclitaxel. Dose escalations were performed according to the time to event continual reassessment method (TITE-CRM), starting at 120 mg to a maximum dose of 240 mg daily (qd). The TITE-CRM used an empirical dose-toxicity model, with a sample size of 15 evaluable patients. HDAC score was performed retrospectively on primary and/or metastatic tissue. Results: 17 pts were accrued between 3/16-2/18: 15 were evaluable. Of evaluable pts, 3 had triple negative BC and 12 hormone receptor (HR)+/HER2-. The mean number of prior lines was 4 (range: 0-9). The first pt started at 120 mg qd, the second at 180 mg qd, and the rest at 240 mg qd. No dose limiting toxicities were seen. The only grade 3 event thought to be medication-related was syncope in 1 pt. No grade IV events were seen. In evaluable pts, the following were best responses: 1 partial response (PR), 9 stable disease (SD), and 3 progressive disease (PD: 2 TNBC, 1 HR+/HER2-). Two pts recently started and were too early to report. In the first 6 evaluable pts, the HDAC6 score (network size = 243) could significantly dichotomize those with PD vs. SD/PR (p = 0.05). Conclusions: ACY-1215 240 mg qd is safe and tolerable with weekly nab-paclitaxel. Clinical activity has been observed, with the majority of pts demonstrating SD and 1 with a PR. Notably, the HDAC6 score appears to preliminarily predict activity. We plan on presenting updated data, including HDAC6 score on additional pts, with data maturity. Clinical trial information: NCT02632071.
Excessive Se on RuSe2 nanocrystals to accelerate water dissociation for the enhanced electrocatalytic hydrogen evolution reaction (2020)

Selenium-enriched RuSe2 (RuxSe) nanocrystals as electrocatalysts for the HER in basic media have been synthesized via a facile hydrothermal method followed by a calcination process. The catalytic activity of the obtained RuxSe nanocrystals is greatly dependent on calcination temperatures. The nanocrystals obtained at 400 °C (RuxSe-400) demonstrate the highest HER activity with a low overpotential of 45 mV to deliver a current density of 10 mA cm-2 and a small Tafel slope of 31.4 mV dec-1. The enhanced catalytic HER performance of RuxSe-400 could be attributed to the excessive Se on the RuSe2 nanocrystal surface. Density functional theory (DFT) calculations reveal that the excessive Se would lower the energy barrier for water dissociation and lessen the dependence on the Ru sites for OH* adsorption but have a negligible effect on hydrogen adsorption energy, leading to an accelerated HER process. Furthermore, the excessive Se on the nanocrystal surface further endows the catalyst with promoted charge-transfer kinetics, ensuring a more efficient catalytic reaction. The strategy herein for the design of highly efficient HER catalysts by engineering the separation of different intermediate (H* and OH*) adsorption sites is expected to be extended to other electrocatalysts for high-efficiency energy conversion.
ChemInform Abstract: STEREOSELEKTIVE SYNTH. DES RACEMISCHEN C‐17‐JUVENILHORMONS VON CECROPIA (1972)

Abstract Aus dem Famesylsäureester (I) wird das Epoxid (II) dargestellt, das durch Hydratisierung in das Diol (III) bzw. durch NaJO4‐ Spaltung von (III) in den Aldehyd (IVa) übergeführt wird.
Structure-Guided Optimization of Small-Molecule Folate Uptake Inhibitors Targeting the Energy-Coupling Factor Transporters (2021)

Here, we report on a potent class of substituted ureidothiophenes targeting energy-coupling factor (ECF) transporters, an unexplored target, which is not addressed by any antibiotic on the market. Since the ECF module is crucial for the vitamin transport mechanism, prevention of substrate uptake should ultimately lead to cell death. By utilizing a combination of virtual and functional whole-cell screening of our in-house library, the membrane-bound protein mediated uptake of folate could be effectively inhibited. Structure-based optimization of our hit compound yielded low-micromolar inhibitors, whereby the most active compounds showed in addition potent antimicrobial activities against a panel of clinically relevant Gram-positive pathogens without significant cytotoxic effects.
Die optimale Abfertigungskapazität des Wartesystems GI/G/c (1974)

Das Bearbeitungszentrum eines Wartesystems vom Typ GI/G/c umfaßt c parallele, identische Kanäle. Die Ankünfte der Elemente an diesem Zentrum sind einem rekurrenten Prozeß der Intensität λ unterworfen. Findet ein ankommendes Element einen Kanal des Zentrums leer vor, so wird es sofort bedient; andernfalls wartet es in der Schlange. Die Bearbeitungszeiten der Elemente sind identisch verteilte stochastische Variable mit beliebiger Verteilungsfunktion. Nach dem Abschluß ihrer Bearbeitung verlassen die Elemente das System. Die Bearbeitung der Elemente und ihre Wartezeit verursachen Kosten, die sich als Kosten pro Element oder als Kosten pro Zeiteinheit angeben lassen. Die Anzahl c der Bearbeitungskanäle sei fest vorgegeben, doch seien die Kanäle konstruktiv so ausgelegt, daß die Bearbeitungsrate μ bei jedem Kanal innerhalb gewisser Grenzen variiert werden kann. Sie soll so bestimmt werden, daß die Kosten des Wartesystems minimal sind. Nun sind die Kosten zufällige Veränderliche, da die Bearbeitungsdauer und die Wartezeit eines Elements schwanken. Mithin stellt die Aufgabe, den kostenminimalen Wert der Bearbeitungsrate zu bestimmen, ein Entscheidungsproblem unter Risikc. Das klassische „μ -Kriterium“ (Vgl. SCTG EEWEISS [1967]; hier steht μ für den Erwartungswert einer beliebigen Zufallsvariablen, nicht für eine Bearbeitungsrate) schreibt vor, den Erwartungswert der Kosten als Zielfunktion zu benutzen.
Sex Selectivity of Mouse Ultrasonic Songs (2007)

In many species, reproduction requires detecting, recognizing, and courting a potential mate. Progress through these stages is guided by cues involving a wide range of sensory systems. Here we explore the tasks of detection, recognition, and response in terms of the ultrasonic songs of male mice presented with odor cues contained in urine. We find that the quantity of singing, more so than specific features of the songs, varies depending upon the odor cue. For experienced male mice, responses to female odor cues depend only on the concentration of female cues and are independent of the presence of male cues. However, for naive mice, male cues appear to be synergistic for the response to female cues. We therefore find no direct behavioral evidence for a role of opponent neural processing, such as lateral inhibition, in distinguishing sex by olfactory cues. However, modeling demonstrates that lateral inhibition could be one possible mechanism to account for the switch from synergy to independence.
Mass spectrometric identification of the trypsin cleavage pathway in lysyl‐proline containing oligotuftsin peptides (2007)

Trypsin cleaves specifically peptide bonds at the C-terminal side of lysine and arginine residues, except for -Arg-Pro- and -Lys-Pro- bonds which are normally resistant to proteolysis. Here we report evidence for a -Lys-Pro- tryptic cleavage in modified oligotuftsin derivatives, Ac-[TKPKG]4-NH2) (1), using high-resolution mass spectrometry and HPLC as primary methods for analysis of proteolytic reactions. The proteolytic susceptibility of -Lys-Pro- bonds was strongly dependent on flanking residues, and the flexibility of the peptide backbone might be a prerequisite for this unusual cleavage. While -Lys-Gly- bonds in 1 were rapidly cleaved, the modification of these Lys residues by the attachment of a ss-amyloid(4-10) epitope to yield -Lys(X)-Gly derivatives prevented cleavage of this bond, and provided trypsin cleavage of -Lys-Pro- bonds, the pathway of this degradation being independent on the type of Lys-N(epsilon)-side chains (acetyl group, amino acid, peptide). Substitution of the Lys residues by Ala at the P'2 positions decreased the tryptic cleavage, while replacement of the bulky side chain of Thr at the P2 positions strongly increased the cleavage of -Lys-Pro- bonds. Circular dichroism (CD) data of the modified oligotuftsin derivatives are in accord with enhanced flexibility of the peptide backbone, as a prerequisite for increased susceptibility to cleavage of -Lys-Pro- bonds. These results obtained of oligotuftsin derivatives might have implications for the proteolytic degradation of target peptides that require specific conformational preconditions.
ChemInform Abstract: REGIOSPECIFICITY IN REACTIONS OF METAL PHENOXIDES. SYNTHESIS OF 2,2′‐ALKYLIDENEBISPHENOLS (1982)

Abstract Die Kondensation von phenolischen Grignard‐Verbindungen mit aliphatischen Aldehyden verläuft regiospezifisch über die o‐Position der Phenole: Bildung von 1,1‐Diaryl‐ alkanen, wie z.B. (II).
Dissection of a Synthesized Quantitative Trait to Characterize Transgene Interactions (1997)

Six transgenic tobacco lines, each homozygous for the beta-glucuronidase (GUS) gene at a different locus, and wild type were selfed and intercrossed to evaluate GUS activity in all possible hemizygous, homozygous and dihybrid combinations of GUS alleles. The transgenic lines are characterized by their GUS activity (two low, three intermediate, one high), T-DNA complexity (four single-copy, two more complex single-locus) and the presence of the chicken lysozyme matrix-associated region (MAR) around the full T-DNA (two lines). Gene action and interaction was analyzed by weighted linear regression with parameters for additivity, dominance and epistasis. The analysis showed that each of the four single-copy lines acted fully additively. In contrast, the two complex single-locus lines showed classical single-locus overdominance and were epistatic dominant over all other GUS alleles. The latter is manifested in severe suppression of GUS activity in dihybrid lines, irrespective of the presence of MAR elements around the GUS gene. Such elements apparently do not protect against epistatic dominance. The quantitative data suggested that the epistatic dominance and overdominance are based on the same molecular mechanism. Our approach of a genetic analysis of quantitative variation in well-characterized transgenic lines provides a powerful tool to gain insight into complex plant traits.
The centralized formulation for complete dynamic modelling of robots (2000)

The centralized formulation for the inertia element of robot dynamics found by using the composite rigid body is very efficient. However, the corresponding formulation for the centrifugal, Coriolis, and gravity elements has not been addressed. Based on certain special motion states of a composite rigid body, this article presents the centralized formulation for all the inertial, centrifugal, Coriolis, and gravity elements. This formulation shows a very direct relationship with the mass, inertia, and Jacobian matrix columns of a composite rigid body. Compared with other modelling formulations, it requires the minimum computational complexity. Thus, highly efficient complete dynamic modelling of robots can be achieved. ©2000 John Wiley & Sons, Inc.
SOCIAL SERVICES Programs and Protection for Children and Youth: Control Who May Have Access to Records Concerning Child Abuse Reports (1992)

The Act changes who may have access to child abuse records and what information such persons may be given. The Act also repeals the clause indicating that records shall not be released if such release would cause loss of federal funds.
Sickle red blood cell derived extracellular vesicles activate endothelial cells and enhance sickle red cell adhesion mediated by von Willebrand factor (2022)

ABSTRACT Endothelial activation and sickle red blood cell (RBC) adhesion are central to the pathogenesis of sickle cell disease (SCD). Quantitatively, RBC-derived extracellular vesicles, REVs, are more abundant from SS RBCs compared with healthy RBCs (AA RBCs). Sickle RBC-derived REVs (SS REVs) are known to promote endothelial cell (EC) activation through cell signaling and transcriptional regulation at longer terms. However, the SS REV-mediated short term non transcriptional response of EC is unclear. Here, we examined the impact of SS REVs on acute microvascular EC activation and RBC adhesion at 2 hours. Compared with AA REVs, SS REVs promoted human pulmonary microvascular endothelial cells (HPMEC) activation indicated by increased von Willebrand Factor (vWF) expression. Under microfluidic conditions, we found abnormal SS RBC adhesion to HPMECs exposed to SS REVs. This enhanced SS RBC adhesion was reduced by vWF cleaving protease ADAMTS13 to a level similar to HPMECs treated with AA REVs. Consistent with these observations, studies in SS mice with implanted dorsal skin-fold chambers found hemin-induced stasis was inhibited by ADAMTS13. The adhesion induced by SS REVs was variable, and was higher with SS RBCs from patients with increased markers of hemolysis (LDH and reticulocyte count) or a concomitant clinical diagnosis of deep vein thrombosis. Our results emphasize the critical contribution made by REVs to the pathophysiology of SCD by triggering acute microvascular EC activation and abnormal RBC adhesion. These findings may help to better understand acute pathophysiological mechanism of SCD and thereby the development of new treatment strategies using vWF as a potential target.
Novel applications of bioanalytical techniques for proteomic research (2000)

Following a brief presentation of a popular methodology currently employed to diagnose diseases, a specific technique, Enzyme-Linked Immunosorbent Assay (ELISA), which employs this methodology is introduced. The advantages of using a waterfall enzyme cascade for ELISA detection over the commonly employed single enzymatic detection system were explored. The results indicate that only slight improvements in detection can be achieved with this implementation. An alternative methodology to diagnosis is then presented. A newly emerging field of research which employs this methodology is Proteomics. It is envisioned that with Proteomics, the entire protein complement of organism's genomes can be identified. At the forefront of Proteomic efforts a reduction in the massive number of proteins will be necessary. This reduction was explored through the selection of peptide fragments which contain the rare amino acid cysteine. Positive confirmation of this selection was achieved with the peptide fragments of a single protein. As equally important in Proteomic efforts will be the use of mass spectrometry. In particular, the mass spectral analysis of complex peptide mixtures. The role of spectral suppression due to both varying concentration and amino acid composition of the peptide fragments were explored. The results indicate that both of the above mentioned factors are equally important to consider. Finally, the advantage of using an on-column, in contrast to a free solution, enzymatic digest to generate peptide fragments was studied. The results indicate that in addition to enhanced proteolysis, peptide fragments generated via an on-column process are free of disulfide bond scrambled artifacts.
Biosynthesis of leupeptin. III. Isolation and properties of an enzyme synthesizing acetyl-L-leucine. (1980)

An enzyme which catalyzes acetylation of L-leucine with acetyl-CoA was partially purified from a cell extract of Streptomyces roseus MA839-A1, a leupeptin producer. The molecular weight of this enzyme is about 27,000 daltons. The enzyme has fairly broad specificity for acyl donors (I) and acceptors (II): as for I, propionyl-CoA was 1/10 as active as acetyl-CoA with L-leucine as the acceptor; as for II, L-leucyl-D-leucine, L-leucyl-L-leucine, L-arginine, L-leucyl-L-leucyl-L-leucine, L-phenylalanine, L-methionine, L-leucine, glycyl-L-phenylalanine and L-valine were acetylated in the decreasing order, as opposed to no or slight reactivity of D-phenylalanine, D-leucine, L-histidine, glycine, L-proline and L-glutamic acid. The Michaelis constants of acetyl-CoA and L-leucine were about 5 X 10(-6) M and 6 X 10(-5) M, respectively. The enzyme is stimulated by Fe++. p-Chloromercuribenzoic acid (PCMB), N-ethylmaleimide, Mg++ and Mn++ were inhibitory. A leupeptin-nonproducing mutant, Streptomyces roseus MA839-A1 LN-S, derived from the producer strain by acriflavine treatment, also produced this enzyme.
Vision models and quality metrics for image processing applications (2001)

These Ecole polytechnique federale de Lausanne EPFL, n° 2313 (2000)Faculte des sciences et techniques de l'ingenieurInstitut de genie electrique et electroniqueLaboratoire de traitement des signaux 1Jury: Michel Benard, Jean-Bernard Martens, Philippe Robert, Christian Van den Branden Lamb, Pierre Vandergheynst Public defense: 2001-2-2 Reference doi:10.5075/epfl-thesis-2313Print copy in library catalog Record created on 2005-03-16, modified on 2016-08-08
Contention Resolution for Optical Switching: Tuning the Channel and Delay Selection Algorithm (2010)

Optical packet switching and burst switching provide future-proof alternatives to the current electronic switching in the backbone. To resolve burst (or packet) contention, fiber delay lines are put to use as buffers, as vital part of a channel and delay selection (CDS) algorithm. In case no void-filling is applied, earlier studies pointed out that minimal loss is obtained by selecting delay lines and channels according to a minimal gap (MING) strategy. The current contribution reexamines this strategy, and presents a general CDS optimization method based on a Markov decision process. Applying this method to a specific setting, we found that several well-tuned CDS algorithm outperform MING. Exact expressions are given for a two-channel configuration with general inter-arrival times and fixed burst sizes. Detailed results for CDS optimization of a specific setting are included, showing that the traffic load has a crucial impact on the optimum found. Some CDS algorithms consistently outperform MING (for any value of the load), whereas others are only optimized for either high or low traffic load.
Lorentz Transformation Under a Discrete Dynamical Time and Continuous Space (2022)

Abstract The Lorentz transformation of space and time between two reference frames is one of the pillars of the special relativity theory. As a result of the Lorentz transformation, space and time are only relative and are entangled, while the Minkowski metric is Lorentz invariant. For this reason, the Lorentz transformation is one of the major obstructions in the development of physical theories with quantized space and time. Here is described the Lorentz transformation of a physical system with a discrete dynamical time and a continuous space that fulfills Lorentz invariance while approximating the Lorentz transformation at the time continuous limit and the Galilei transformation at the classical limit. Furthermore, the discreteness of time is not mixed with the continuous nature of space, making time distinct from space.