gebhart/patrepeval huggingface dataset:
Suppressive Oligodeoxynucleotides Promote the Development of Th17 Cells (2013)

Synthetic oligonucleotides containing repetitive TTAGGG motifs mimic the immunosuppressive activity of telomeric DNA. These suppressive oligonucleotides (Sup ODN) are effective in the treatment/prevention of various inflammatory and autoimmune diseases in mice. The therapeutic activity of Sup ODN was originally attributed to the inhibition of Th1 cell activation. Current results indicate that Sup ODN also promote the maturation of naive CD4(+) T cells into Th17 effectors. The generation of Th17 cells is linked to the prolonged activation of signal transducer and activator of transcription (STAT)3 mediated by suppressor of cytokine signaling 3 (SOCS3) inhibition. In vivo studies show that treatment with Sup ODN promotes Th17 responsiveness under physiological conditions, increasing host resistance to Candida albicans infection. These findings support the development of Sup ODN to suppress pathological inflammatory conditions and improve host resistance to fungal pathogens.
An Analytical Model Describing Multipeak Pulse Structure in Actively Q-Switched Fiber Lasers (2007)

We present a simple analytical model describing the detailed structure of actively Q- switched fiber ring laser pulses. The predicted pulse shapes match experimental data with an accuracy comparable with a numerical traveling-wave model.
Finite element simulation of a local scale air quality model over complex terrain (2012)

Abstract. In this paper we propose a finite element method approach for modelling the air quality in a local scale over complex terrain. The area of interest is up to tens of kilometres and it includes pollutant sources. The proposed methodology involves the generation of an adaptive tetrahedral mesh, the computation of an ambient wind field, the inclusion of the plume rise effect in the wind field, and the simulation of transport and reaction of pollutants. We apply our methodology to simulate a fictitious pollution episode in La Palma island (Canary Island, Spain).
Decoupling end-to-end QoS provisioning from service provisioning at routers in the diffserv network model (2005)

In this paper, a novel concept of decoupling the end-to-end QoS provisioning from the service provisioning at routers in the Diffserv network is proposed to enhance the QoS granularity offered in the Diffserv model and improve both the network resource utilization and user benefits. To realize the concept, we implement a new endpoint admission control, referred to as explicit endpoint admission control, with the service vector concept at the user side, which allows a data flow to choose different services at different routers. At the router side, we propose a new packet marking scheme, by which the end host can obtain the performance of each service class at each router and determine the service vector. The achievable performance of the proposed approach is studied and the corresponding results demonstrate that the proposed mechanism can have better service differentiation capability and lower request dropping probability than the Intserv over Diffserv schemes while it still maintains the simplicity feature of the Diffserv network model.
Scan-chain design and optimization for three-dimensional integrated circuits (2009)

Scan chains are widely used to improve the testability of integrated circuit (IC) designs and to facilitate fault diagnosis. For traditional 2D IC design, a number of design techniques have been proposed in the literature for scan-chain routing and scan-cell partitioning. However, these techniques are not effective for three-dimensional (3D) technologies, which have recently emerged as a promising means to continue technology scaling. In this article, we propose two techniques for designing scan chains in 3D ICs, with given constraints on the number of through-silicon-vias (TSVs). The first technique is based on a genetic algorithm (GA), and it addresses the ordering of cells in a single scan chain. The second optimization technique is based on integer linear programming (ILP); it addresses single-scan-chain ordering as well as the partitioning of scan flip-flops into multiple scan chains. We compare these two methods by conducting experiments on a set of ISCAS'89 benchmark circuits. The first conclusion obtained from the results is that 3D scan-chain optimization achieves significant wire-length reduction compared to 2D counterparts. The second conclusion is that the ILP-based technique provides lower bounds on the scan-chain interconnect length for 3D ICs, and it offers considerable reduction in wire-length compared to the GA-based heuristic method.
The Effect of Impeller Inlet Annular Turning Vanes on Multistage Centrifugal Compressor Performance (1996)

The flow path of multistage centrifugal compressors is characterized by two 180-degree turns per stage: the inlet turning bend connecting the radial inflow return channel with the radial outflow impeller and the cross-over bend connecting the radial outflow diffuser with the return channel. Due to higher flow velocity and larger width to turning radius ratio, the turning losses are substantially higher in the inlet bend than in the return channel bend. Performance measurements were taken using different annular through-flow turning vane arrangements designed to reduce the inlet turning losses and increase the overall efficiency of the multistage centrifugal compressor. The experiments have shown consistent efficiency gains with corresponding capacity increases by adding multiple annular turning vanes in the inlet bend. The performance improvement potential of the vanes depends strongly on the positioning of these vanes in the flow passage. Based on these results, an empirical turning loss model was developed with the capability to predict the performance improvement achievable with correctly positioned single or multiple turning vanes in the impeller inlet bend area.
Opportunistic Multiparty Calibration for Robust Participatory Sensing (2017)

While bringing massive-scale sensing at low cost, mobile participatory sensing is challenged by the low accuracy of the sensors embedded in and/or connected to the smartphones. The mobile measurements that are collected need to be corrected so as to accurately match the phenomena being observed. This paper addresses this challenge by introducing a multi-hop, multiparty calibration method that operates in the background in an automated way. Using our method, sensors that are within a relevant sensing (and communication) range coordinate so that the observations of the participating (previously) calibrated sensors serve calibrating the other participants. As a result, our method is particularly well suited for participatory sensing within crowd meetings, as for instance within public spaces. Our solution leverages multivariate linear regression, together with robust regression so as to discard the measurements that are of too low quality for being meaningful. To the best of our knowledge, we are the first to introduce a multiparty calibration algorithm, while previous work in the area focused on pairwise calibration. The paper further introduces a supporting prototype implemented over Android, and related experiment in the context of noise sensing.We show that the proposed multiparty calibration system enhances the accuracy of the mobile noise sensing application.
Deep Convolutional Neural Network based Classification of Alzheimer's\n Disease using MRI data (2021)

Alzheimer's disease (AD) is a progressive and incurable neurodegenerative\ndisease which destroys brain cells and causes loss to patient's memory. An\nearly detection can prevent the patient from further damage of the brain cells\nand hence avoid permanent memory loss. In past few years, various automatic\ntools and techniques have been proposed for diagnosis of AD. Several methods\nfocus on fast, accurate and early detection of the disease to minimize the loss\nto patients mental health. Although machine learning and deep learning\ntechniques have significantly improved medical imaging systems for AD by\nproviding diagnostic performance close to human level. But the main problem\nfaced during multi-class classification is the presence of highly correlated\nfeatures in the brain structure. In this paper, we have proposed a smart and\naccurate way of diagnosing AD based on a two-dimensional deep convolutional\nneural network (2D-DCNN) using imbalanced three-dimensional MRI dataset.\nExperimental results on Alzheimer Disease Neuroimaging Initiative magnetic\nresonance imaging (MRI) dataset confirms that the proposed 2D-DCNN model is\nsuperior in terms of accuracy, efficiency, and robustness. The model classifies\nMRI into three categories: AD, mild cognitive impairment, and normal control:\nand has achieved 99.89% classification accuracy with imbalanced classes. The\nproposed model exhibits noticeable improvement in accuracy as compared to the\nstate-fo-the-art methods.\n
Comparison of groundwater flow in Southern California coastal aquifers (2009)

Development of the coastal aquifer systems of Southern California has resulted in overdraft, changes in streamflow, seawater intrusion, land subsidence, increased vertical flow between aquifers, and a redirection of regional flow toward pumping centers. These water-management challenges can be more effectively addressed by incorporating new understanding of the geologic, hydrologic, and geochemical setting of these aquifers.
Comparison of Digene Hybrid Capture 2 and Conventional Culture for Detection of Chlamydia trachomatis and Neisseria gonorrhoeae in Cervical Specimens (2002)

Digene's Hybrid Capture 2 (HC2) CT/GC, CT-ID, and GC-ID DNA tests were evaluated by comparison to traditional culture methods for detecting Chlamydia trachomatis and Neisseria gonorrhoeae infections in 669 cervical specimens from high-risk female populations attending two sexually transmitted disease clinics. For detection of either or both infections, the HC2 CT/GC test algorithm had 93.8% sensitivity and 95.9% specificity compared to those of culture. After resolution of discrepant results by direct fluorescent-antibody (DFA) staining or PCR assay, the relative sensitivity and specificity of the HC2 CT/GC test algorithm increased to 94.8 and 99.8%, while the values for culture were 83.6% (McNemar's P value, 0.0062) and 100%, respectively. For detection of the individual pathogens, the relative sensitivities for the HC2 CT-ID and GC-ID tests were 97.2 and 92.2% and the specificities were greater than 99% compared to culture adjucated by DFA staining and PCR. Test performance varied at the two clinics: the HC2 CT/GC algorithm, CT-ID, and GC-ID tests had significantly higher sensitivities (McNemar's P value, <0.05) than that of culture for the population at one clinic as well as for the combined populations. At the other clinic, the HC2 tests performed as well as culture.
Fundamental Studies of Charge Migration and Delocalization Relevant to Solar Energy Conversion (2012)

This program aimed to understand the molecular-level principles by which complex chemical systems carry out photochemical charge separation, transport, and storage, and how these insights could impact the design of practical solar energy conversion and storage devices. Towards these goals, this program focused on: (1) carrying out fundamental mechanistic and transient dynamical studies of proton-coupled electron-transfer (PCET) reactions; (2) characterizing and interrogating via electron paramagnetic resonance (EPR) spectroscopic methods novel conjugated materials that feature large charge delocalization lengths; and (3) exploring excitation delocalization and migration, as well as polaron transport properties of meso-scale assemblies that are capable of segregating light-harvesting antennae, nanoscale wire-like conduction elements, and distinct oxidizing and reducing environments.
ChemInform Abstract: Stereocontrolled Solution and Solid Phase Enolate Alkylations and Hydroxylations — Generation of Three and Four Contiguous Stereogenic Carbon Atoms in Acyclic Systems. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Spontaneous Silencing of Humanized Green Fluorescent Protein (hGFP) Gene Expression from a Retroviral Vector by DNA Methylation (1998)

We have constructed a functional murine leukemia virus (MLV)-derived retroviral vector transducing two genes encoding the autofluorescent humanized green fluorescent protein (hGFP) and neomycin phosphotransferase (Neo). This was done to determine whether hGFP could function as a marker gene in a retroviral vector and to investigate the expression of genes in a retroviral vector. Surprisingly, clonal vector packaging cell lines showed variable levels of hGFP expression, and expression was detected in as few as 49% of the cells in a clonally derived culture. This indicated that hGFP expression was silenced in individual cells. This silencing could be diminished by selective culturing of the vector packaging cells with the neomycin analog G418 and was reduced by a 3-day treatment with the demethylating agent 5-azacytidine. The 5-azacytidine effect was transient, and hGFP expression in the vector packaging cells returned to untreated control levels within 2 weeks. Using flow cytometric analysis, hGFP expression was detected in up to 15% of transduced MT4 cells (a CD4+ lymphocytic cell line) after coculturing with packaging cells for 4 days. A 3-day postcoculture treatment with 5-azacytidine was shown to increase the hGFP-expressing MT4 cells from either 10.4% to 11.6% or 3.7% to 4.8%, corresponding to an increase in observed transduction efficiencies of 12% and 30%, respectively. These results indicate that silencing of gene expression from a retroviral vector may result from DNA methylation and occurs rapidly after transduction.
An instrument for measuring the resistivity of metals and metallic alloys (1970)

An instrument is described which enables the resistivity of metals or metallic alloys to be continuously monitored with the accuracy of 1 part in 104. By using a square current waveform the thermal emf and contact potential contributions are eliminated. The use of integrated circuit operational amplifiers allows for an overall design simplicity and relatively low cost to be achieved.
Measurement of the optical parameters of the Virgo interferometer (2007)

The Virgo interferometer, aimed at detecting gravitational waves, is now in a commissioning phase. Measurements of its optical properties are needed for the understanding of the instrument. We present the techniques developed for the measurement of the optical parameters of Virgo. These parameters are compared with the Virgo specifications.
Development of Sn Solder Plating Containing Cellulose Nanofiber (2022)

We focused on low-cost and high-strength cellulose nanofibers (CNFs) as a substitute for Ag used for lead- free solder material. In this study, Sn/conductive CNF composite plating film was formed on a Cu plate after the CNFs were given electrical conductivity by sulfide reduction treatment. After plating, two Cu plates with the Sn/conductive CNF composite plating film were heated and joined to investigate the microstructure of the solder joint. It was found that conductive CNFs were incorporated into Sn plating films, while after joining, the conductive CNFs were agglomerated due to the melting of Sn.
Speaking Mexicano: Dynamics of Syncretic Language in Central Mexico. (1988)

The Hills confront far more than what is 'sayable' in terms of Mexicano grammar; they deal with what is actually said, with the relationship between Spanish and Mexicano as resources in the community's linguistic repertoire...One of the major studies of language contact produced within the past forty years. Language The genius of this work is the integration of the linguistic analysis with the cultural and political analysis. Latin American Anthropology Review
A New Formula for Vietnamese Text Readability Assessment (2018)

Text readability has an important role in text drafting and document selecting. Most studies on the readability of the text have been made long ago for English and some common languages. There are few researches about Vietnamese text readability and most of them are performed more than three decades ago on very small corpora. In this paper, we build a new and larger corpus and use it to create a newer formula to predict the difficulty of Vietnamese text. The experimental results show that the new formula can predict the readability of Vietnamese documents with over 80% accuracy.
Comparative efficiency of volume and synaptic transmission in the coerulean system: relevance to neurologic rehabilitation (1993)

Over the past few years evidence has accumulated which confirms earlier beliefs that punctate synaptic transmission (wiring transmission) is not the only means by which "informational substances" affect cerebral neurons. This paper considers the relative efficiency of "volume" and "wiring" transmission in controlling large populations of neurons taking as a specific example the mammalian coerulean system. Making reasonable quantitative assumptions it is shown that volume transmission is a more efficient means of controlling "mass" functions than a wiring mode. Implications for the reorganisation of function following brain damage are noted.
The Life Assessment by Linear Cumulative Damage Rule for Cold Dwell Fatigue of Ti-6Al-4V (2021)

Fatigue life of Ti alloys is decreased by tensile stress dwell even at room temperature, which is called Cold Dwell Fatigue (CDF). CDF is similar to creep-fatigue of some metals (stainless steel, Ni-base alloy, and so on) in the point of decrease of fatigue life with stress or strain dwell at high temperature. In this study, time exhaustion rule and ductility exhaustion rule based on linear cumulative damage rule were calculated for CDF life assessments. In the case of time exhaustion rule, total damage was calculated as DF+DC< (0.03, 0.015) (DF: fatigue damage, DC: creep damage). In the case of ductility exhaustion rule, total damage was calculated as DF+DC~1. Additionally, the feature of fracture surfaces after CDF tests changed with increase of dwell time. This trend corresponded to the balance between fatigue damage and creep damage calculated by ductility exhaustion rule.
Mixing Pens and the Future of Diabetes Drugs (2015)

With the availability of a smaller mixing pen, mass marketing of less stable medications is possible. Bidureon is one such medication, and the properties of its pen are discussed along with the prospects for future mixing pens.
Intrapulse modulation recognition based on pulse description words (2013)

The intrapulse modulation recognition of radar signals is an important part of the radar reconnaissance. By means of the digital channelized receiver on processing simultaneous signals, the recognition method in this paper accomplishes the separation and recognition of the different modulated signals from a complex multiple environment with simultaneous signals. Further, from the statistical characteristics of the intrapulse instantaneous frequency, the modulation types can be recognized and the modulation parameters can be extracted using this method. The experimental result provided the effectiveness of this proposed method.
Optical fiber amplifiers for space-division multiplexing (2012)

最近，空间部门 multiplexing (SDM ) 技术使用多核心纤维(MCF ) 和很少模式纤维(FMF ) 被介绍了进光纤维通讯增加传播能力。光纤维放大器的二种主要类型基于 Erbiumdoped 纤维(EDF ) 和拉曼效果被开发了在 MCF 和 FMF 放大信号。在这份报纸，我们考察了这些放大器的原则和配置。
A Simple and Scalable Static Analysis for Bound Analysis and Amortized Complexity Analysis (2014)

We present the first scalable bound analysis that achieves amortized complexity analysis. In contrast to earlier work, our bound analysis is not based on general purpose reasoners such as abstract interpreters, software model checkers or computer algebra tools. Rather, we derive bounds directly from abstract program models, which we obtain from programs by comparatively simple invariant generation and symbolic execution techniques. As a result, we obtain an analysis that is more predictable and more scalable than earlier approaches. Our experiments demonstrate that our analysis is fast and at the same time able to compute bounds for challenging loops in a large real-world benchmark. Technically, our approach is based on lossy vector addition systems (VASS). Our bound analysis first computes a lexicographic ranking function that proves the termination of a VASS, and then derives a bound from this ranking function. Our methodology achieves amortized analysis based on a new insight how lexicographic ranking functions can be used for bound analysis.
Applications of Time-Domain High-Resolution Radon Demultiple (2007)

SummaryThe frequency domain high-resolution (HR) Radon transform can provide improved resolution in the curvature direction compared with the frequency domain least squares transform. The time domain HR transform also provides improved resolution in the time direction, and, paradoxically, in many cases also a further improvement of the resolution in the curvature direction. In this paper the effect of the improved resolution is studied on synthetic and field data, and it is shown that particularly for more complex data, the time domain HR Radon transform can provide improved demultiple efficiency, aliasing protection and primary preservation, compared with the frequency domain HR Radon transform.
A Self-Assembled Coumarin-Anchored Dendrimer for Efficient Gene Delivery and Light-Responsive Drug Delivery (2018)

The assembly of low molecular weight polymers into highly efficient and nontoxic nanostructures has broad applicability in gene delivery. In this study, we reported the assembly of coumarin-anchored low generation dendrimers in aqueous solution via hydrophobic interactions. The synthesized material showed significantly improved DNA binding and gene delivery, and minimal toxicity on the transfected cells. Moreover, the coumarin moieties in the assembled nanostructures endow the materials with light-responsive drug delivery behaviors. The coumarin substitutes in the assembled nanostructures were cross-linked with each other upon irradiation at 365 nm, and the cross-linked assemblies were degraded upon further irradiation at 254 nm. As a result, the drug-loaded nanoparticle showed a light-responsive drug release behavior and light-enhanced anticancer activity. The assembled nanoparticle also exhibited a complementary anticancer activity through the codelivery of 5-fluorouracil and a therapeutic gene encoding tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). This study provided a facile strategy to develop light-responsive polymers for the codelivery of therapeutic genes and anticancer drugs.
THE ATLANTIC TELEGRAPH pages 1 to 54 (2011)

A summary is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Fusion of uniluminal vascular spheroids: A model for assembly of blood vessels (2010)

Abstract Blood vessel formation via vascular fusion. When placed into hanging drop culture, five uniluminal vascular spheroids fuse to form a single, larger diameter spheroid with an outer layer of smooth muscle alpha actin positive cells (red) and an inner PECAM‐1 positive endothelium (green) surrounding a large central lumen. From Fleming et al., Developmental Dynamics 239:398–406, 2010.