gebhart/patrepeval huggingface dataset:
Antilactoferrin antibodies in patients with rheumatoid arthritis are associated with vasculitis (1992)

Anti-LF Ab in serum of patients with RA may be useful in the diagnosis of vasculitis in RA.
Stimulation of insulin secretion and associated nuclear accumulation of iPLA2β in INS-1 insulinoma cells (2002)

Accumulating evidence suggests that the cytosolic calcium-independent phospholipase A(2) (iPLA(2)beta) manifests a signaling role in insulin-secreting (INS-1) beta-cells. Earlier, we reported that insulin-secretory responses to cAMP-elevating agents are amplified in iPLA(2)beta-overexpressing INS-1 cells (Ma Z, Ramanadham S, Bohrer A, Wohltmann M, Zhang S, and Turk J. J Biol Chem 276: 13198-13208, 2001). Here, immunofluorescence, immunoaffinity, and enzymatic activity analyses are used to examine distribution of iPLA(2)beta in stimulated INS-1 cells in greater detail. Overexpression of iPLA(2)beta in INS-1 cells leads to increased accumulation of iPLA(2)beta in the nuclear fraction. Increasing glucose concentrations alone results in modest increases in insulin secretion, relative to parental cells, and in nuclear accumulation of the iPLA(2)beta protein. In contrast, cAMP-elevating agents induce robust increases in insulin secretion and in time-dependent nuclear accumulation of iPLA(2)beta fluorescence, which is reflected by increases in nuclear iPLA(2)beta protein content and specific enzymatic activity. The stimulated effects are significantly attenuated in the presence of cell-permeable inhibitors of protein phosphorylation and glycosylation. These findings suggest that conditions that amplify insulin secretion promote translocation of beta-cell iPLA(2)beta to the nuclei, where it may serve a crucial signaling role.
A novel multiparametric imaging approach to acute myocarditis using T2-mapping and CMR feature tracking (2016)

A multiparametric CMR imaging model including the novel T2-mapping derived parameter madSD, the feature tracking derived strain parameter GCS<sub>LV</sub> and LGE yields superior diagnostic sensitivity in suspected acute myocarditis when compared to any imaging parameter alone and to LLC.
Olfactory reference syndrome: a systematic review of the world literature (2010)

ORS is a primary psychiatric syndrome that does not fit well into its current classification as a subtype of delusional disorder, both in terms of its nosology and its response to treatment.
ABTS: A Safe Alternative to DAB for the Enhancement of Blood Fingerprints (2000)

The use of 2,2'-azino-di-[3-ethylbenzthiazolinesulfonate(6)] diammonium salt (ABTS) for the enhancement of fingerprints in blood has been investigated. Optimal pH conditions and H2O2 concentrations have been determined using UV/Vis spectroscopy. ABTS is an effective and safe noncarcinogenic (though more expensive) alternative to the presently used 3,3'-diaminobenzidine (DAB) for the development of blood fingerprints, especially on porous surfaces. The bright green color of the oxidized ABTS is an advantage on certain colored surfaces where the dark brown color of DAB does not stand out well from the background. Development with ABTS does not interfere with subsequent DAB treatment, making ABTS a "nothing-to-lose" reagent. ABTS can be used after ninhydrin treatment, but the reverse is not the case.
Thermal decomposition of polystyrene in supercritical methanol (2008)

Abstract The degradation of polystyrene (PS) in supercritical methanol was carried out under reaction temperatures ranging from 340 to 420°C and pressures of 10–30 MPa. The selectivity of liquid products was investigated at various reaction conditions. As the reaction proceeded, the selectivity of styrene monomer, dimer, 1,3‐diphenyl propane, and 1,3‐diphenyl butane had a declining tendency, whereas that of the rest (i.e., toluene, ethyl benzene, isopropyl benzene, and 3‐phenyl propanol, etc.) had an inclining tendency. The sequences of decomposition reaction could be reasoned by analyzing the variation of selectivity of liquid products. The kinetic behavior of PS in supercritical methanol had been investigated. The degradation processes of PS in such supercritical fluids could be formulated by the first‐order kinetic law at the initial stage of reaction. The activation energy for the degradation in supercritical methanol was evaluated to be 117.2 kJ/mol and it was also compared with the activation energies for depolymerization in other supercritical fluids and that for thermal pyrolysis. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008
Ranges of energetic ions in matter (1981)

Based on standard transport theory for the slowing down of heavy ions in matter, a fast and efficient method has been developed for the calculation of range-distribution parameters. The method allows for the use of arbitrary nuclear-scattering cross sections and electronic energy-loss functions, and all target-ion combinations can be handled. Examples of calculations of the mean projected ranges and the longitudinal- and transverse-range stragglings for high-energy heavy ions are presented. The results are compared with existing experimental data.
Persistent Infection with West Nile Virus Years after Initial Infection (2009)

West Nile virus (WNV) RNA was demonstrated in 5 (20%) of 25 urine samples collected from convalescent patients 573-2452 days (1.6-6.7 years) after WNV infection. Four of the 5 amplicons sequenced showed >99% homology to the WNV NY99 strain. These findings show that individuals with chronic symptoms after WNV infection may have persistent renal infection over several years.
ChemInform Abstract: INTERMEDIATES IN THE INTRAMOLECULAR LIGAND TRANSFER REACTIONS OF H(5)‐C5H5FE(CO)2R COMPLEXES (1975)

Abstract Die Eisencarbonylkomplexe (I) bilden beim Lösen in verschiedenen Lösungsmitteln wie Acetonitril, Dimethylsulfoxid, Methylenchlorid, Aceton, Essigester, Benzol, Tetrahydrofuran oder Heptan einen Übergangskomplex ,z.B. (II), der mit Triphenylphosphin unter Austausch des Lösungsmittel‐Liganden weiterreagiert.
Conversion of highly concentrated cellulose to 1,2-propanediol and ethylene glycol over highly efficient CuCr catalysts (2013)

Direct hydrogenolysis of highly concentrated cellulose (up to 15 wt%) into 1,2-propanediol and ethylene glycol without the formation of coke-like precipitates could be performed over CuCr catalysts. Addition of Ca(OH)2 results in a significant increase in the EG yield.
Complete Genome Sequence of Borrelia crocidurae (2012)

We announce the draft genome sequence of Borrelia crocidurae (strain Achema). The 1,557,560-bp genome (27% GC content) comprises one 919,477-bp linear chromosome and 638,083-bp plasmids that together carry 1,472 open reading frames, 32 tRNAs, and three complete rRNAs, with almost complete colinearity between B. crocidurae and Borrelia duttonii chromosomes.
Functional Vitamin D Receptor (VDR) in the T-Tubules of Cardiac Myocytes: VDR Knockout Cardiomyocyte Contractility (2007)

We have previously shown that the active form of vitamin D, 1,25 dihydroxyvitamin D3 [1,25(OH)(2)D(3)], has both genomic and rapid nongenomic effects in heart cells; however, the subcellular localization of the vitamin D receptor (VDR) in heart has not been studied. Here we show that in adult rat cardiac myocytes the VDR is primarily localized to the t-tubule. Using immunofluorescence and Western blot analysis, we show that the VDR is closely associated with known t-tubule proteins. Radioligand binding assays using (3)H-labeled 1,25(OH)(2)D(3) demonstrate that a t-tubule membrane fraction isolated from homogenized rat ventricles contains a 1,25(OH)(2)D(3)-binding activity similar to the classic VDR. For the first time, we show that cardiac myocytes isolated from VDR knockout mice show accelerated rates of contraction and relaxation as compared with wild type and that 1,25(OH)(2)D(3) directly affects contractility in the wild-type but not the knockout cardiac myocyte. Moreover, we observed that acute (5 min) exposure to 1,25(OH)(2)D(3) altered the rate of relaxation. A receptor localized to t-tubules in the heart is ideally positioned to exert an immediate effect on signal transduction mediators and ion channels. This novel discovery is fundamentally important in understanding 1,25(OH)(2)D(3) signal transduction in heart cells and provides further evidence that the VDR plays a role in heart structure and function.
Asymmetric beam generation in an on-chip 2D-pattern-projecting lasers (2018)

We successfully generate an asymmetric beam pattern in integrable phase-modulating surface-emitting lasers, which showed static, arbitrary, two-dimensional beam pattern from on-chip size, while symmetric beam patterns are obtained in the conventional device.
Osteogenic Induction of Human Periodontal Ligament Fibroblasts Under Two- and Three-Dimensional Culture Conditions (2006)

Human periodontal ligament fibroblasts (hPDLF) play a key role in the regeneration of periodontal compartment during guided tissue regeneration procedures. This property is attributed to the progenitor cell subsets residing in the area. The aim of this study was to investigate whether hPDLFs could undergo an osteogenic differentiation under two- and three-dimensional (2D and 3D) culture conditions upon osteogenic induction. hPDLFs were isolated from six healthy donors, cultured, and expanded according to standard protocols. Then, three osteogenic culture conditions (dexamethasone, ascorbic acid, and beta-glycerophosphate) were established: 1) 2D culture as single-cell monolayer, 2) 3D-static culture on mineralized poly(DL-lactic-co-glycolic acid) (PLGA) scaffold, and 3) 3D culture on mineralized PLGA scaffold inside the NASA-approved bioreactor stimulating microgravity conditions. After 21 days of osteogenic induction, the majority of monolayer cultures had undergone differentiation toward osteogenic lineage, as indicated by morphological changes, mineralization assay, and some phenotypical properties. However, immunohistochemistry revealed that the scaffold cultures expressed higher levels of osteogenic marker proteins compared with that of the monolayers. Secondly, hPDLF-PLGA constructs in bioreactor showed an increased expression of osteopontin and osteocalcin compared with that of static 3D culture after 21 days. Results indicate that human periodontal ligament contains a subpopulation of cells capable of undergoing osteogenic differentiation and presumably contributing to regeneration of bone defects in the adjacent area. Human PDLF-seeded mineralized PLGA scaffold in microgravity bioreactor may be used to support osteogenic differentiation in vitro. Thus, this system may offer new potential benefits as a tool for periodontal tissue engineering.
How Single and Bifurcated Hydrogen Bonds Influence Proton‐Migration Rate Constants, Redox, and Electronic Properties of Phenoxyl Radicals (2004)

Hydrogen-bonded phenoxyl radicals are made and the strength of the hydrogen bond between the O(phenoxyl) and the H(ammonium) atoms strongly affects their stability. The rate constants for the intramolecular proton-migration process in these systems are reported and a bifurcated hydrogen-bonded system has been characterized (see model). Investigations show that the proton transfer from the phenoxyl-radical cation to the tertiary amine is assisted by a neighboring nitrogen atom. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2004/z52368_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Stable Nuclear Pleiotropic Respiratory-Deficient Mutants with Modified Mitochondrial Cytochrome a + a3 and Adenosine Triphosphatase in a ‘Petite-Negative’ Yeast Schizosaccharomyces pombe (1974)

Conference Article| April 01 1974 Stable Nuclear Pleiotropic Respiratory-Deficient Mutants with Modified Mitochondrial Cytochrome a + a3 and Adenosine Triphosphatase in a ‘Petite-Negative’ Yeast Schizosaccharomyces pombe A. GOFFEAU; A. GOFFEAU 1Laboratoire d'Enzymologie, Université de Louvain, Kardinaal Mercierlaan 92, 3030 Heverlee, Belgium Search for other works by this author on: This Site PubMed Google Scholar A. M. COLSON; A. M. COLSON 1Laboratoire d'Enzymologie, Université de Louvain, Kardinaal Mercierlaan 92, 3030 Heverlee, Belgium Search for other works by this author on: This Site PubMed Google Scholar Y. LANDRY; Y. LANDRY 1Laboratoire d'Enzymologie, Université de Louvain, Kardinaal Mercierlaan 92, 3030 Heverlee, Belgium Search for other works by this author on: This Site PubMed Google Scholar F. FOURY; F. FOURY 1Laboratoire d'Enzymologie, Université de Louvain, Kardinaal Mercierlaan 92, 3030 Heverlee, Belgium Search for other works by this author on: This Site PubMed Google Scholar M. BRIQUET M. BRIQUET 1Laboratoire d'Enzymologie, Université de Louvain, Kardinaal Mercierlaan 92, 3030 Heverlee, Belgium Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1974) 2 (2): 223. https://doi.org/10.1042/bst0020223 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation A. GOFFEAU, A. M. COLSON, Y. LANDRY, F. FOURY, M. BRIQUET; Stable Nuclear Pleiotropic Respiratory-Deficient Mutants with Modified Mitochondrial Cytochrome a + a3 and Adenosine Triphosphatase in a ‘Petite-Negative’ Yeast Schizosaccharomyces pombe. Biochem Soc Trans 1 April 1974; 2 (2): 223. doi: https://doi.org/10.1042/bst0020223 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search nav search search input Search input auto suggest search filter All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1974 Biochemical Society1974 Article PDF first page preview Close Modal You do not currently have access to this content.
Are lignin-derived carbon fibers graphitic enough? (2019)

The extent of graphitization is an overlooked limitation to lignin-derived carbon fiber development.
Identification of class-mu glutathione transferase genes GSTM1-GSTM5 on human chromosome 1p13. (1993)

The GSTM1, GSTM2, GSTM3, GSTM4, and GSTM5 glutathione transferase genes have been mapped to human chromosome 1 by using locus-specific PCR primer pairs spanning exon 6, intron 6, and exon 7, as probes on DNA from human/hamster somatic cell hybrids. For GSTM1, the assignment was confirmed by Southern blot hybridization to a pair of 12.5/2.4-kb HindIII fragments. The GSTM1-specific primer pairs can be used to identify individuals carrying non-null GSTM1 alleles. The organization of these five genes was confirmed by the isolation of a yeast artificial chromosome clone (GSTM-YAC2) that contains all five genes. With this clone, the location of the GSTM1-GSTM5 gene cluster on chromosome 1 was confirmed by fluorescence in situ hybridization. Both regional assignment using the fractional length method and examination of probe signal with reference to R-banded chromosomes induced by BrdU places the gene cluster in or near the 1p13.3 region. The close physical proximity of the GSTM1 and GSTM2 loci, which share 99% nucleotide sequence identity over 460 nucleotides of 3'-untranslated mRNA, suggests that the GSTM1-null allele may result from unequal crossing-over.
Poster: Studies of Propeller Aerodynamics for UAV Tethered System Development (2021)

The placement of sensing systems mounted on multirotor UAV is essential to perform accurate measurements. In an effort to reduce the noise acquired by the sensors, product of the turbulence generated by the propeller of multirotor UAV, a tip vortex characterization is realized where quantitative and qualitative analysis is done to install the sensing systems on the quadcopter.
Molecular Recognition of Lipid Antigens by T Cell Receptors (1999)

The T cell antigen receptor (TCR) mediates recognition of peptide antigens bound in the groove of major histocompatibility complex (MHC) molecules. This dual recognition is mediated by the complementarity-determining residue (CDR) loops of the alpha and beta chains of a single TCR which contact exposed residues of the peptide antigen and amino acids along the MHC alpha helices. The recent description of T cells that recognize hydrophobic microbial lipid antigens has challenged immunologists to explain, in molecular terms, the nature of this interaction. Structural studies on the murine CD1d1 molecule revealed an electrostatically neutral putative antigen-binding groove beneath the CD1 alpha helices. Here, we demonstrate that alpha/beta TCRs, when transferred into TCR-deficient recipient cells, confer specificity for both the foreign lipid antigen and CD1 isoform. Sequence analysis of a panel of CD1-restricted, lipid-specific TCRs reveals the incorporation of template-independent N nucleotides that encode diverse sequences and frequent charged basic residues at the V(D)J junctions. These sequences permit a model for recognition in which the TCR CDR3 loops containing charged residues project between the CD1 alpha helices, contacting the lipid antigen hydrophilic head moieties as well as adjacent CD1 residues in a manner that explains antigen specificity and CD1 restriction.
Memory efficient progressive rate-distortion algorithm for JPEG 2000 (2005)

A novel rate-distortion optimization algorithm for JPEG 2000 is proposed. In JPEG 2000 standard, the encoder generates a number of independent compressed bit streams. But it is the rate-control algorithm that generates truncation points for these bit streams in an optimal way in order to minimize the distortion according to a target bit rate. In this letter, we propose a computationally efficient rate-distortion optimization algorithm that generates the truncation points of the compressed bit streams during the encoding procedure to avoid unnecessary coding of the possible discarded bit streams for the given bit rate. This algorithm meets memory buffer requirement for the compressed bit streams quite strictly according to a given bit rate. Moreover, before the encoding process even starts, a required memory buffer size can be estimated. This algorithm can also help avoid unnecessary encoding for some parts of an image. Hence, it is memory efficient and supports progressive encoding also. In low bit rate application the proposed algorithm can greatly reduce the encoder complexity and buffer requirement.
Nitric Oxide Synthase Function in Exercise (2008)

Endothelial cells (ECs) regulate blood flow and pressure, platelet aggregation, and angiogenesis. Chemical (e.g. acetylcholine, bradykinin) and mechanical stimuli (linear shear stress and pulse pressure) enhance endothelial production of nitric oxide (NO). In the mammalian three isoforms of NO synthase [endothelial (eNOS), inducible (iNOS) and neuronal (nNOS)] are expressed in different cell types showing a specific subcellular compartmentalization with colocalized effectors. The NOS-guanylyl-cyclase-protein kinase G (PKG) system plays a key role in mediating specific signaling involved in both short- and long-term control of several functions. In particular, mechanical-induced NO release may act as an amplifier of the local metabolic vasodilator(s) during exercise. It is likely that mechanical-induced increase in eNOS and extra-cellular superoxide dismutase expression and activity contribute to the augmentation of endothelial function during exercise training. NO-induced cGMP activates PKG, which phosphorylates other kinases to regulate their activity, leading to a reduction of cytosolic Ca2+ and, thus, to vascular relaxation. c-Src and other kinases are also activated and play a pivotal role as intracellular signaling molecules during exercise training, which may also lead to genomic and nongenomic changes. Endothelial dysfunction is a component of atherogenic activity, diabetes and other vascular risk factors which lead to coronary heart disease and heart failure. In patients, training may improve NO production that explains beneficial effects of exercise, such as lowered lipoprotein level, increased vasodilatation and reduced vasoconstriction. The improved outcomes may be due, in part, to the positive effect of exercise on NOSs function, kinase activation and, consequently, on endothelial dependent vasodilatation. Keywords: Exercise, nitric oxide synthase, vasodilatation, endothelium, cGMP, PKC, c-Src, ERK
PTR1: a reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major. (1994)

Trypanosomatid protozoans are pterin auxotrophs, a finding noted decades ago which heralded the discovery of key metabolic roles played by pteridines in eukaryotes. We have now identified the enzyme mediating unconjugated pteridine salvage in the human parasite Leishmania major, PTR1 (pteridine reductase 1, formerly hmtxr or ltdh). PTR1 is the gene in the amplified H region responsible for methotrexate (MTX) resistance, and belongs to a large family of oxidoreductases with diverse substrates and roles. We generated Leishmania lacking PTR1 by homologous gene targeting, and these ptr1- mutants required reduced biopterin (dihydro- or tetrahydrobiopterin) for growth. PTR1 purified from engineered Escherichia coli exhibited a MTX-sensitive, NADPH-dependent biopterin reductase activity. PTR1 showed good activity with folate and significant activity with dihydrofolate and dihydrobiopterin, but not with quinonoid dihydrobiopterin. PTR1 thus differs considerably from previously reported pteridine reductases of trypanosomatids and vertebrates. Pteridine reductase activity was diminished in ptr1- Leishmania and was elevated in transfected parasites bearing multiple copies of PTR1; correspondingly, ptr1- was MTX-hypersensitive whereas the multicopy transfectant was MTX-resistant. The concordance of the biochemical and genetic properties of PTR1 suggests that this is the primary enzyme mediating pteridine salvage. These findings suggest several possible mechanisms for PTR1-mediated MTX resistance and should aid in the design of rational chemotherapy.
Current Issues in Adjuvant Chemotherapy for Resected, Stage IB Non-Small-Cell Lung Cancer (2009)

Evaluation of: Strauss GM, Herndon JE 2nd, Maddaus MA et al.: Adjuvant paclitaxel plus carboplatin compared with observation in stage IB non-small-cell lung cancer: CALGB 9633 with the Cancer and Leukemia Group B, Radiation Therapy Oncology Group, and North Central Cancer Treatment Group Study Groups. J. Clin. Oncol. 26, 5043–5051 (2008). The CALGB 9633 study was designed to evaluate the efficacy of carboplatin and paclitaxel given in the adjuvant setting to patients with Stage IB non-small-cell lung cancer. Although interim analysis had shown clinical benefit, longer follow-up revealed lack of efficacy for this approach. We will examine the results of this trial in light of other positive adjuvant trials in patients with non-small-cell lung cancer.