gebhart/patrepeval huggingface dataset:
Preventing Input Validation Vulnerabilities in Web Applications through Automated Type Analysis (2012)

Web applications have become an integral part of the daily lives of millions of users. Unfortunately, web applications are also frequently targeted by attackers, and critical vulnerabilities such as cross-site scripting and SQL injection are still common. As a consequence, much effort in the past decade has been spent on mitigating web application vulnerabilities. Current techniques focus mainly on sanitization: either on automated sanitization, the detection of missing sanitizers, the correctness of sanitizers, or the correct placement of sanitizers. However, these techniques are either not able to prevent new forms of input validation vulnerabilities such as HTTP Parameter Pollution, come with large runtime overhead, lack precision, or require significant modifications to the client and/or server infrastructure. In this paper, we present IPAAS, a novel technique for preventing the exploitation of cross-site scripting and SQL injection vulnerabilities based on automated data type detection of input parameters. IPAAS automatically and transparently augments otherwise insecure web application development environments with input validators that result in significant and tangible security improvements for real systems. We implemented IPAAS for PHP and evaluated it on five real-world web applications with known cross-site scripting and SQL injection vulnerabilities. Our evaluation demonstrates that IPAAS would have prevented 83% of SQL injection vulnerabilities and 65% of cross-site scripting vulnerabilities while incurring no developer burden.
Computer-aided design and GaAs realizations of 4.8 and 9.6 Gbit/s optical receivers (1990)

Up until now the simplified "real frequency" technique has been applied to the design of broadband multistage microwave amplifiers where gain and VSWR are optimized, In this paper we extend the method to the design of transimpedance amplifier for a wide band optical receiver . So the noise is optimized in parallel with the gain and VSWR. The synthesis of the networks (equalizer) is carried out in two ways, with lumped elements arid distributed elements. Then we give several examples of design ; transimpedance amplifier and ultra wide band GaAs amplifier.
Generative One-Shot Learning (GOL): A Semi-Parametric Approach to One-Shot Learning in Autonomous Vision (2018)

Highly Autonomous Driving (HAD) systems rely on deep neural networks for the visual perception of the driving environment. Such networks are train on large manually annotated databases. In this work, a semi-parametric approach to one-shot learning is proposed, with the aim of bypassing the manual annotation step required for training perceptions systems used in autonomous driving. The proposed generative framework, coined Generative One-Shot Learning (GOL), takes as input single one-shot objects, or generic patterns, and a small set of so-called regularization samples used to drive the generative process. New synthetic data is generated as Pareto optimal solutions from one-shot objects using a set of generalization functions built into a generalization generator. GOL has been evaluated on environment perception challenges encountered in autonomous vision.
Brittle metallic glass deforms plastically at room temperature in glassy multilayers (2009)

Bulk metallic glasses are emerging as a new class of materials that can have applications ranging from structural materials to materials for future nanotechnology. However, catastrophic mechanical failure is a serious issue hindering the use of these materials in engineering applications. Here we introduce an approach to understanding and solving the problem of brittleness of metallic glasses. We have shown that even a very brittle metallic glass (La based) can be forced to deform plastically at room temperature if it is made in the form of multilayers involving other metallic glasses, i.e., a two-phase glass. The mechanically soft glassy layer (La based) having a lower critical shear stress acts as a nucleation or an initiation site for shear bands and the mechanically hard glassy layer (Zr based) acts as an obstacle to the propagation of shear bands. This process results in the multiplication of shear bands. Since the shear bands are associated with a local rise in temperature, a large number of shear bands can raise the overall temperature of the soft layer and eventually can drive it to the supercooled liquid state, where deformation of metallic glass is very large and homogeneous. The results reported here not only clarify the mechanism of large plastic deformation in two-phase glassy alloys but also suggest the possibility of a different kind of two-phase bulk glassy alloys exhibiting large plastic deformation at room temperature.
In-silico Characterisation of the Kirkstall QV900 In-Vitro System for Advanced Cell Culture (2017)

We have developed an in-silico model of the Kirkstall Quasi-Vivo QV900 cell culture system. The QV900 consists of a series of connected sealed chambers, within which cells can be cultured in a low shear stress flow environment. By modelling fluid flow and oxygen transport within the chambers, we have been able to simulate flow patterns and shear stress/oxygen levels experienced by the cells, and we have demonstrated that physiologically relevant oxygen concentration gradients can be achieved by configuring connected chambers in a particular way.
Auto-Oil Program Phase II Heavy Hydrocarbon Study: Fuel Species Oxidation Chemistry and Its Relationship to the Auto-Oil Data (1994)

&lt;div class="htmlview paragraph"&gt;The oxidation chemistry of paraffins, aromatics, olefins and MTBE were examined. Detailed chemical kinetics calculations were carried out for oxidation of these compounds in the engine cycle. The oxidation rates are very sensitive to temperature. At temperatures of over 1400 K (depending on the fuel), all the hydrocarbons are essentially oxidized for typical residence time in the engine. Based on the kinetics calculations, a threshold temperature is defined for the conversion of the fuel species to CO, CO&lt;sub&gt;2&lt;/sub&gt;, H&lt;sub&gt;2&lt;/sub&gt;O and partially oxidized products. The difference in the survival fraction between aromatics and non-aromatics is attributed to the higher threshold temperature of the aromatics.&lt;/div&gt;
Current concepts in the treatment of acne: report from a clinical roundtable. (2003)

Acne vulgaris is the most common skin disorder in the United States, affecting approximately 17 million people. This figure includes 80% of all persons between the ages of 11 and 30 years, regardless of race, ethnicity, or gender (Kraning and Odland, 1979). Acne has a significant economic and social impact on doctor visits, medications, and absenteeism, as well as in the negative effect it can have on self-image and outlook, especially during the emotionally critical period of adolescence. Persons with acne may think of themselves as unworthy and socially unacceptable. Severe acne may lead to scarring and disfigurement, aggravating the already present psychosocial aspects of this condition. Because of the multifactorial nature of acne, current treatment options aim to modify one or more of its pathogenic factors. Clinical experience has shown that combination therapies, which affect multiple aspects of pathophysiology, are most likely to achieve this goal and help in its long-term management and resolution.
Brocresine in Parkinson's disease: Action of a peripheral and central decarboxylase inhibitor in potentiating levodopa (1973)

Brocresine, an aromatic L-amino acid decarboxylase inhibitor with both a peripheral and central action was shown to potentiate the therapeutic effect of levodopa in Parkinson's disease. The search for useful decarboxylase inhibitors therefore need not be limited to agents that do not pass the blood/brain barrier.
Modeling and Visualization for Polymers, Surfaces and Biomolecules. (1997)

Abstract : Our research emphasizes efficient algorithms and data structures for biomolecular modeling and visualization. The main research thrusts of this contract are: The computation of the topological, combinatorial and metric properties of the molecular structure of polymers and biomolecules based on weighted alpha shapes; The determination of similarities between two or more polymers or biomolecules based on geometric matching of the determined structural properties of the molecules; The development and graphical simulation of localized molecular docking strategies based on road map calculations on convolution surfaces of the interacting molecule structures and localized regions of the potential energy surfaces; The modeling, visualization and manipulation of the molecules together with their potential energy surfaces; The implementation of the above algorithms in an existing distributed (multi-user and multi-workstation) geometric software environment.
QUE ES LA LUMBALGIA (1988)

¨QUE ES LA LUMBALGIA?, TEXTO EDITADO POR LA UNAM DEL DOCTOR ARTURO HEREDIA MARQUEZ, SUBDIRECTOR DE ALTO RENDIMIENTO DE LA DIRECCION GENERAL DE ACTIVIDADES DEPORTIVAS Y RECREATIVAS, SOBRE LA LUMBALGIA, LOS TRANSTORNOS QUE CAUSA Y CONSEJOS SOBRE COMO CUIDAR LA COLUMNA VERTEBRAL.
Enhanced intracellular calcium concentration during poliovirus infection (1995)

The infection of human fibroblasts by poliovirus leads to a notable increase in the intracellular calcium concentration, [Ca2+]i, measured by microfluorimetry or by flow cytometry. [Ca2+]i increases from 2 to 3 h postinfection, and by the fifth hour there is a 5- to 10-fold increase in [Ca2+]i. At this time postinfection there is active viral protein synthesis. The modifications in [Ca2+]i are not observed in the presence of cycloheximide, guanidine, or Ro 09-0179, indicating that virus gene expression is required for the increase in [Ca2+]i. Attempts to identify the source of the intracellular Ca2+ by using different inhibitors of calcium fluxes suggest that calcium enters from the culture medium through voltage-sensitive calcium channels.
Antegrade Versus Retrograde Cerebral Perfusion in Aortic Surgery: Systematic Review and Meta-Analysis of 19365 Patients (2022)

Background Since the risk of neurological injury and mortality can be mitigated with the appropriate choice of established brain protection strategies, we performed a meta-analysis of studies reporting cerebral perfusion strategy outcomes. Our focus was on surgeries that can be performed through a minimally-invasive approach, to support the decision-making process of adopting surgeons. Methods We searched the Excerpta Medica dataBASE (EMBASE), Medical literature analysis and retrieval system online (MEDLINE), and Cochrane databases, as well as ClinicalTrials.gov, Google Scholar, and the reference lists of relevant articles for studies reporting early mortality and/or stroke outcomes of both retrograde cerebral perfusion (RCP) and antegrade cerebral perfusion (ACP) strategies. The principal summary measures were odds ratio (OR) with 95% confidence interval (CI) and p values (statistically significant when &lt;0.05). The pooled ORs were combined across studies that met the eligibility criteria. Results We identified and included seventeen eligible studies with a total of 19,365 patients undergoing ascending aorta and arch surgery from 2008-2019 by means of ACP (a total of 10,473 patients) or RCP (a total of 8,892 patients). Random effect model analyses found no increase in mortality (OR=1.03, 95%CI:0.80-1.32) or stroke (OR=1.04, 95%CI:0.81-1.32) associated RCP when compared to ACP (p&gt;0.05). Conclusion In ascending aorta and arch surgery, requiring cerebral protection, ACP and RCP have similar rates of early mortality and stroke. While optimal application of cerebral protection strategies is both patient and surgeon specific, surgeons can comfortably adopt RCP in minimally invasive cases after accounting for factors that determine the outcomes of aortic surgery adequately.
Oligodendrocyte precursor cell transplantation promotes functional recovery following contusive spinal cord injury in rats and is associated with altered microRNA expression (2017)

It has been reported that oligodendrocyte precursor cells (OPCs) may be used to treat contusive spinal cord injury (SCC), and may alter microRNA (miRNA/miR) expression following SCC in rats. However, the association between miRNA expression and the treatment of rats with SCC with OPC transplantation remain unclear. The present study transplanted OPCs into the spinal cord of rats with SCC and subsequently used the Basso, Beattie and Bresnahan (BBB) score to assess the functional recovery and pain scores. An miRNA assay was performed to detect differentially expressed miRNAs in the spinal cord of SCC rats transplanted with OPCs, compared with SCC rats transplanted with medium. Quantitative polymerase chain reaction was used to verify significantly altered miRNA expression levels. The results demonstrated that OPC transplantation was able to improve motor recovery and relieve mechanical allodynia in rats with SCC. In addition, through a miRNA assay, 45 differentially expressed miRNAs (40 upregulated miRNAs and 5 downregulated miRNAs) were detected in the spinal cord of rats in the OPC group compared with in the Medium group. Differentially expressed miRNAs were identified according to the following criteria: Fold change >2 and P<0.05. Furthermore, quantitative polymerase chain reaction was used to verify the most highly upregulated (miR‑375‑3p and miR‑1‑3p) and downregulated (miR‑363‑3p, miR‑449a‑5p and miR‑3074) spinal cord miRNAs that were identified in the miRNA assay. In addition, a bioinformatics analysis of these miRNAs indicated that miR‑375 and miR‑1 may act primarily to inhibit cell proliferation and apoptosis via transcriptional and translational regulation, whereas miR‑363, miR‑449a and miR‑3074 may act primarily to inhibit cell proliferation and neuronal differentiation through transcriptional regulation. These results suggested that OPC transplantation may promote functional recovery of rats with SCC, which may be associated with the expression of various miRNAs in the spinal cord, including miR‑375‑3p, miR‑1‑3p, miR‑363‑3p, miR‑449a‑5p and miR‑3074.
RF heating in cavity-bellows of CW SRF cryomodule (2020)

Abstract In a cryomodule, bellows are commonly used to connect two adjacent superconducting cavities. It provides cavities a mechanical flexibility facilitating for thermal contraction or expansion during temperature transitions. While heat from superconducting cavities are removed from helium flowing through their jackets, non-superconducting bellows are cooled down through a relatively slow process of conduction cooling by adjacent superconducting cavities. An excessive heat deposition to the bellows could results in unsustainable rise in temperature that could lead to a thermal runaway. Because of the bellows proximity to the superconducting cavities, resulting thermal runaway could disrupt performance of the cavities and therefore, overall operation. For this reason, the paper presents a comprehensive assessment of RF heating resulting from most potent dynamic heating mechanisms in the interconnecting cavity bellows of 1.3 GHz, continuous wave, cryomodule of the Linac Coherent Light Source-II linear accelerator. Studies are performed for two types of the bellows surfaces i.e. stainless-steel and copper. The results show that RF heating at stainless-steel surface is about four times higher than at copper surface. In this work we also develop a simplified analytical model to analyse the bellows surface temperature growth resulting from RF heating. The model shows a good agreement with numerical analysis and indicates a temperature growth of up to 70 K in stainless-steel bellows in the steady state. Calculations also show that a thin copper coating of 15 μ m on stainless-steel surface not only reduces RF heating but also confines the temperature growth well within 10 K. The studies presented here attribute practical importance guiding to characterize copper coating requirements for non-superconducting components in a cryomodule and allowing to model a more relevant cryogenic heat load budget accounting for bellows heating.
The History of Land Use Mapping (1981)

(1981). The History of Land Use Mapping. The Cartographic Journal: Vol. 18, No. 1, pp. 45-48.
Updating Formulae and a Pairwise Algorithm for Computing Sample Variances (1982)

A general formula is presented son. computing the sample valiance son a sample of size mtn given the means and valiance son two subsamples of sizes m and n. This formula is used in the construction of a pairwise algorithm son computing the valiance. Other applications are discussed as well including the use of updating formulae in a parallel computing environment. we present resume and rounding error analyze son several numerical schemes.
Pyrimidinones. 1. 2-Amino-5-halo-6-aryl-4(3H)-pyrimidinones. Interferon-inducing antiviral agents (1985)

Interferon induction and antiviral activity was discovered with 2-amino-5-bromo-6-phenyl-4(3H)-pyrimidinone. An analogue study incorporating a series of 2-amino-5-substituted-6-arylpyrimidinones revealed that the most potent interferon inducers were mono- and difluorophenyl analogues. These same analogues were also potent antiviral agents against Semliki Forest virus and herpes simplex type 1. In addition the monomethoxyphenyl analogues were potent antiviral agents but weak interferon inducers. Relatively modest structural changes led to dramatic changes in bioactivity. There was a relatively poor correlation between levels of circulating interferons induced and systemic antiviral activity.
VASCULAR CALCIFICATION IN PATIENTS WITH KIDNEY DISEASE: Calcific Uremic Arteriolopathy: Advances in Pathogenesis and Treatment (2007)

Calcific uremic arteriolopathy (CUA) is a rare but serious life-threatening complication of CRF that manifests as painful nonhealing eschars in association with panniculitis and dermal necrosis. This condition is being increasingly recognized and reported as a contributing factor to death in dialysis patients. The pathognomic lesion is vascular calcification with intimal arterial hypertrophy and superimposed small vessel thrombosis. Hyperparathyroidism and elevated concentrations of serum phosphate remain consistent clinical features of most cases reported. Controversy still exists regarding the role of parathyroidectomy in this condition with some studies suggesting improved outcome with surgical intervention. A number of potential new etiological factors have been identified including reduced serum levels of a calcification inhibitory protein alpha,2-Heremans-Schmid glycoprotein (Fetuin-A) and abnormalities in smooth muscle cell biology in uremia. Promising new treatment options including hyperbaric oxygen therapy and sodium thiosulfate infusion have been reported in case series. Benefits from biphosphonates and tissue plasminogen activator have also been reported. Overall these new treatment approaches and understanding of potential mechanisms underlying this important severe clinical condition offer new hope in the diagnosis and management of this severely morbid and often fatal condition.
Bias Field Gradient Effects of Large Superconducting Quantul Inteference Device (SQUID) Arrays (SQAs) (2019)

In this investigation we explore the effects of nonuniform magnetic bias fields on the voltage-flux curve of large two-dimensional arrays of superconducting quantum interference devices (SQUIDs). The SQUID arrays (SQAs) contain 1020 SQUIDs modeled with parallel coupling in the x-direction and series coupling in the y-direction. Each array is composed of individual SQUID elements having non-uniform size loop areas, resulting in a non-uniform inductance parameter βL, and a single “anti-peak” feature at zero magnetic field in the voltage-flux transfer function. We examine the changed induced in the profile of the transfer function by gradients in the magnetic field in both the x- and y-directions. The height, slope, and symmetry of the anti-peak feature is compared with that from the same SQA exposed to a uniform field.
Combination capecitabine/temozolomide (CAPTEM) in patients with neuroendocrine tumors (NETs): A single institution review. (2015)

e15184 Background: Neuroendocrine tumors (NETs) are commonly treated with multimodality therapy including surgery, somatostatin analogs, targeted agents, chemotherapy and others. The combination of capecitabine and temozolomide (CAPTEM) has been suggested as a treatment option for metastatic disease, however, prospective data is accruing. We sought to review our patient population to determine efficacy and safety of CAPTEM. Methods: This retrospective review included patients with NETs who had been seen at the Louisiana State University/Ochsner NET clinic. Appropriate institutional review board approval was obtained. Patients were identified via an eVelos database. Only NET patients who had been placed on CAPTEM as previously described and received at least one cycle were included for review. Those with inadequate records or without documented follow up were excluded. Response rate (RR) was evaluated by RECIST 1.1. Results: Thirty patients (17 female) were included for review. The median age of CAPTEM initiation was 58.5 (27-77) years. Primary tumors included small bowel, 9 (30%); pancreas, 15 (50%); lung, 4 (13%); and rectum, 2 (7%). There were zero complete responses. Overall partial response (PR) occurred in 10 (33%) patients. Stable disease (SD) occurred in 12 (40%) patients. RRs by Ki-67 and sites are shown in the table. The median duration of response was 330 days. Adverse reactions included fatigue (50%), nausea (40%), cytopenias (25%) and hand foot syndrome (35%) resulting in dose reductions in 23% of patients. Conclusions: CAPTEM provided NET patients another option for treatment that generally produced a long duration of response. CAPTEM seemed to provide clinical benefit in the majority of patients regardless of primary site or Ki-67. While side effects were frequent, most patients were able to tolerate this regimen. CAPTEM may be a consideration in the treatment of NET patients while we await the results of prospective studies to confirm the efficacy of this drug combination. Response by Ki-67 % N PR, n(%) PR + SD, n(%) ≤2 7 2 (29) 6 (86) >2-20 18 7 (39) 13 (72) >20 4 1 (25) 2 (50) Response by site Rectum 2 0 2 (100) Pancreas 15 7 (47) 11 (74) Small Bowel 9 3 (33) 7 (77) Lung 4 0 2 (50)
The Geographic Incidence and Treatment Variation of Common Fractures of Elderly Patients (2006)

Fractures of the hip, wrist, proximal humerus, and ankle frequently are observed among the elderly patient population in the United States. The Medicare patient population has shown dramatic geographic variation in the rates of these common fractures, with an increased incidence observed throughout the Southeast. Treatment (surgical versus nonsurgical) is also highly variable and dependent on the geographic location but not necessarily on the type of injury. Whereas regional variation in medical treatment may be attributed to variations in practice patterns, the etiology behind the dramatic variations in fractures is less well-defined and is likely multifactorial, related to environmental, occupational, genetic, or nutritional factors.