gebhart/patrepeval huggingface dataset:
Preliminary Study on Sexual Behavior of Socially Dominant and Subordinate Boards in a Seminatural Environment (2016)

The objective of this preliminary study was to determine whether domestic pig social dominance confers later reproductive success. Two seminatural environments were established with a feeder, shaded pond, shelter and 2 acres of ground cover with alfalfa. Four prepuberal (2 males and 2 females) pigs were placed on the fields after the post-weaning dominance order was established. Pigs on one field showed a very stable dominance order, while the other field's dominance order was more volatile. Later, additional estrous gilts were brought to each field to determine which boar(s) bred each gilt. Boars shared estrous gilts, that is, both boars on each field bred estrous gilts. Fathership of litters from resident gilts was also shared by both boars on each field. Certain males which were socially dominant mounted estrous gilts more frequently. But all boars shared breedings of estrous gilts and paternity of litters.
Age Dependency of Successful Recanalization in Anterior Circulation Stroke: The ENDOSTROKE Study (2013)

This study emphasizes the dramatic impact of patients' age on outcome in EVT for M1-MCA or carotid T occlusion, even in the presence of recanalization. Reasons for this age-related decrease in clinically successful recanalization rates urgently need clarification and may comprise patient-related factors (age-related increase in cardioembolic strokes, collateral status, comorbidities) as well as periprocedural issues (tortuous vessel anatomy in the elderly, age-dependent negative impact of general anesthesia in EVT).
Background incidence rates of adverse pregnancy outcomes in the Netherlands; data of 2006-2018. (2020)

Objective To assess background rates of adverse pregnancy outcomes before implementation of a maternal pertussis immunisation programme in the Netherlands, to put into perspective the safety concerns about such outcomes following immunisation. Design Retrospective cross-sectional study. Setting and population Dutch pregnant women and their infants who were registered in the Dutch Perinatal Registry in the 2006-2018 period. Births of ≥500g birth weight and ≥24+0w gestational age were included. Methods Annual numbers of adverse outcomes were used to calculate incidence rates per 10,000. Trends with moving-average-lines over the past 3 years were plotted, with 95% confidence interval. Main Outcome Measures Adverse outcomes at maternal and neonatal level. Results From 2006 through 2018, yearly numbers of pregnancies ranged between 158,868-175,710. Numbers of newborns ranged between 161,307-178,874, of whom 160,838-178,177 were live-born. Most outcomes were stable over time. Between 2006-2011, occurrence of labour induction increased by 68%, and postpartum hemorrhage increased by 25%. Both stabilised from 2011 onwards. Perinatal mortality up to day 7 or 28 postpartum decreased by 38% and 37%, respectively. Occurrence of low Apgar score among preterm infants born before 37+0w gestational age and among term infants increased by 19% and 27%, respectively. Conclusions Our study on background incidences showed notable increases over time in occurrence of labour induction, postpartum hemorrhage and low Apgar score, while showing a considerable decrease in overall perinatal mortality. These findings should be considered when interpreting data on adverse events occurring since Tdap vaccination was implemented.
ChemInform Abstract: Methyl Complexes of the Transition Metals (2016)

Abstract Review: [recent advances; 254 refs.
The Bilateral Filter for Point Clouds (2017)

Point sets obtained by 3D scanners are often corrupted with noise, that can have several causes, such as a tangential acquisition direction, changing environmental lights or a reflective object material. It is thus crucial to design efficient tools to remove noise from the acquired data without removing important information such as sharp edges or shape details. To do so, Fleishman et al. introduced a bilateral filter for meshes adapted from the bilateral filter for gray level images. This anisotropic filter denoises a point with respect to its neighbors by considering not only the distance from the neighbors to the point but also the distance along a normal direction. This simple fact allows for a much better preservation of sharp edges. In this paper, we analyze a parallel implementation of the bilateral filter adapted for point clouds.
DMCMN: Experimental/Analytical Evaluation of the Effect of Tip Mass on Atomic Force Microscope Cantilever Calibration (2009)

Quantitative studies of material properties and interfaces using the atomic force microscope (AFM) have important applications in engineering, biotechnology, and chemistry. Contrary to what the name suggests, the AFM actually measures the displacement of a microscale probe, so one must determine the stiffness of the probe to find the force exerted on a sample. Numerous methods have been proposed for determining the spring constant of AFM cantilever probes, yet most neglect the mass of the probe tip. This work explores the effect of the tip mass on AFM calibration using the method of Sader (1995, “Method for the Calibration of Atomic Force Microscope Cantilevers,” Rev. Sci. Instrum., 66, pp. 3789) and extends that method to account for a massive, rigid tip. One can use this modified method to estimate the spring constant of a cantilever from the measured natural frequency and Q-factor for any mode of the probe. This may be helpful when the fundamental mode is difficult to measure or to check for inaccuracies in the calibration obtained with the fundamental mode. The error analysis presented here shows that if the tip is not considered, then the error in the static stiffness is roughly of the same order as the ratio of the tip’s mass to the cantilever beam’s. The area density of the AFM probe is also misestimated if the tip mass is not accounted for, although the trends are different. The model presented here can be used to identify the mass of a probe tip from measurements of the natural frequencies of the probe. These concepts are applied to six low spring-constant, contact-mode AFM cantilevers, and the results suggest that some of the probes are well modeled by an Euler–Bernoulli beam with a constant cross section and a rigid tip, while others are not. One probe is examined in detail, using scanning electron microscopy to quantify the size of the tip and the thickness uniformity of the probe, and laser Doppler vibrometry is used to measure the first four mode shapes. The results suggest that this probe’s thickness is significantly nonuniform, so the models upon which dynamic calibration is based may not be appropriate for this probe.
ARINC 653 and multi-core microprocessors &#x2014; Considerations and potential impacts (2012)

Increased usage of multi-core processors in consumer products “Multi-core processors represent the majority of systems shipped since 2006. For recent installations and upgrades, single-core processor share is now in the very low single digits.” (HPC Wire - June 7, 2012 on High Performance Computing trends);A vionics is minor user of world-wide processor usage; Analysis of standard-based software environments such as ARINC 653 can occur in advance of completing multi-core based platform certifications.
Identification of SUMO Target Proteins by Quantitative Proteomics (2008)

The identification of target proteins for small ubiquitin-like modifiers (SUMOs) is a critical step towards a detailed understanding of the cellular functions of SUMOs. Substrate protein identification for SUMOs is hampered by the low abundance of SUMO targets, the finding that only a small fraction of these target proteins is sumoylated, and the high activity of deconjugating enzymes. Quantitative proteomics is a powerful tool to overcome these challenges, because it allows discrimination between contaminating proteins in SUMO-enriched preparations and true target proteins. In this chapter, the methodological details of the application of stable isotope labeling of amino acids in cell culture (SILAC) for the identification of target proteins for SUMOs are described. In addition to steady state sumoylation, the sumoylated proteome undergoes dynamic rearrangements in response to a diverse array of stimuli. SILAC also allows the study of sumoylation dynamics in response to these stimuli.
Formulation and Evaluation of New Glimepiride Sublingual Tablets (2017)

Oral mucosal delivery of drugs promotes rapid absorption and high bioavailability, with a subsequent immediate onset of pharmacological effect. However, many oral mucosal deliveries are compromised by the possibility of the patient swallowing the active substance before it has been released and absorbed locally into the systemic circulation. The aim of this research was to introduce a new glimepiride formula for sublingual administration and rapid drug absorption that can be used in an emergency. The new sublingual formulation was prepared after five trials to prepare the suitable formulation. Two accepted formulations of the new sublingual product were prepared, but one of them with disintegration time of 1.45 min and searching for preferred formulation, the binder, is changed with Flulac and starch slurry to prepare formula with disintegration time of 21 seconds that supports the aim of research to be used in an emergency. The five formulations were done, after adjusting to the binder as Flulac and aerosil with disintegration time of 21 seconds and accepted hardness as well as the weight variation. The assay of a new product (subglimepiride) is 103% which is a promising result, confirming that the formula succeeded. The new product (subglimepiride) is accepted in most quality control tests and it is ready for marketing.
Use of an atrium for the passive-solar retrofit of an office building: design and installation experience (1982)

A clerestory window system has been installed over a courtyard in an existing two-story office building/museum at the Los Alamos National Laboratory, thus creating an atrium. This atrium serves as a passive solar heating and daylighting system for the building and provides new display space for the museum. The retrofit consists of a roof-mounted clerestory window system with night insulating shutters which: forms an atrium that provides new museum space, buffers the former courtyard walls and windows, preheats ventilation air for the entire building, and provides daylighting and heating for the new museum space. The passive system is coupled to the heating, ventilating, and air-conditioning (HVAC) system of the surrounding building by inducing fresh-air makeup through the solar-tempered atrium; heating, cooling, and daylighting are addressed in the design. The design process, the use of the DOE-2 building energy analysis computer program during design, and the construction of the atrium are described.
Co-ingestion of whole eggs or egg whites with glucose protects against postprandial hyperglycaemia-induced oxidative stress and dysregulated arginine metabolism in association with improved vascular endothelial function in prediabetic men (2018)

Replacing a portion of a glucose challenge with whole eggs (EGG) or egg whites (WHITE) was shown to protect against glucose-induced impairments in vascular function. We hypothesised in the present study that previously observed vasoprotection following co-ingestion of EGG or WHITE with glucose was attributed to limiting postprandial hyperglycaemia-induced oxidative stress that improves NO∙ bioavailability. Prediabetic men completed a randomised, cross-over study in which they ingested isoenergetic meals containing 100 g glucose (GLU), or 75 g glucose with 1·5 EGG, seven WHITE or two egg yolks (YOLK). At 30 min intervals for 3 h, we assessed plasma NO∙ metabolites, the lipid peroxidation biomarker malondialdehyde, antioxidants, arginine and its methylated metabolites (asymmetric dimethylarginine and symmetric dimethylarginine), tetrahydrobiopterin redox status, vasoconstrictors and inflammatory markers. Compared with GLU, malondialdehyde was lower and NO∙ metabolites were greater in EGG and WHITE, but YOLK was not different from GLU. Malondialdehyde was inversely correlated with NO∙ metabolites and vascular function, whereas NO∙ metabolites were positively correlated with vascular function. Compared with GLU, arginine was greater, but asymmetric and symmetric dimethylarginine and angiotensin-II were lower in all egg-based meals. Antioxidants, tetrahydrobiopterin redox status and inflammatory markers did not differ among treatments. Thus, while each egg-based meal improved arginine metabolism, only EGG and WHITE limited lipid peroxidation. This suggests that vasoprotection mediated by EGG and WHITE likely occurs in an NO∙-dependent manner by improving arginine metabolism and attenuating oxidative stress that otherwise limit NO∙ biosynthesis and bioavailability to the vascular endothelium.
Design of fast-response current controller using d-q axis cross coupling: application to permanent magnet synchronous motor drive (1998)

A new current controller, which has both fast transient response in the transient state and high accuracy in the steady state, is proposed. In this scheme, a reference modification part is incorporated with the generally used synchronous frame proportional integral (PI) controller for the fast transient response. Through experimental results, it is observed that the proposed controller has much less transient time than the conventional synchronous PI regulator.
Cellular internalization of bystander nanomaterial induced by TAT-nanoparticles and regulated by extracellular cysteine (2019)

Entry into cells is necessary for many nanomaterial applications, and a common solution is to functionalize nanoparticles (NPs) with cell-penetrating ligands. Despite intensive studies on these functionalized NPs, little is known about their effect on cellular activities to engulf other cargo from the nearby environment. Here, we use NPs functionalized with TAT (transactivator of transcription) peptide (T-NPs) as an example to investigate their impact on cellular uptake of bystander cargo. We find that T-NP internalization enables cellular uptake of bystander NPs, but not common fluid markers, through a receptor-dependent macropinocytosis pathway. Moreover, the activity of this bystander uptake is stimulated by cysteine presence in the surrounding solution. The cargo selectivity and cysteine regulation are further demonstrated ex vivo and in vivo. These findings reveal another mechanism for NP entry into cells and open up an avenue of studying the interplay among endocytosis, amino acids, and nanomaterial delivery.
Influence of Solvent on Radical Trap-Assisted Dimerization and Cyclization of Polystyrene Radicals (2016)

The extent of dimerization in radical trap-assisted atom transfer radical coupling (RTA-ATRC) was studied as a function of solvent composition, with accelerated rates of coupling observed in solvent mixtures consisting of THF and hydrocarbons compared to either pure solvent. Aggregation of the nitroso radical trap was speculated to be responsible for the trend in coupling rates of RTA-ATRC reactions, with less polar solvents such as hydrocarbons favoring the active, monomeric form. The mixed solvent system of THF and cyclohexane was found to be transferrable to the synthesis of macrocyclic PS by intramolecular RTA-ATRC, with 50/50 (v/v) THF:cyclohexane reaction medium giving higher yields of cyclic product compared to reactions performed in the pure solvents.
Role of Telomerase in Hematopoietic Stem Cells (2005)

Studies in hematopoietic stem cell (HSC) biology are often focused on "self-renewal" and differentiation. Implicit in the word self-renewal is that the two daughter cells generated by a self-renewal division are identical to the parental cell. Strictly speaking, this is not possible because DNA is continuously damaged and repaired by DNA-repair mechanisms that are not 100% efficient. It is important to note that the efficiency of DNA repair varies greatly among different stem cell types. For example, embryonic stem cells are quite resistant to DNA damage and maintain the length of telomere repeats on serial passage, whereas HSCs are quite sensitive to DNA damage and less able to maintain telomere length. Most likely, differences between stem cell types in DNA repair and telomere maintenance pathways coevolved with cell mass, turnover, reproductive strategy, and life span. This idea has given rise to the notion that many aspects of normal aging could primarily reflect limitations in DNA repair and telomere-maintenance pathways in the (stem) cells of the soma. In humans, levels of telomerase in HSCs are under extremely tight control, as is illustrated by the marrow failure in patients with (mild) telomerase deficiencies. Here, the role of telomerase in human HSC biology is reviewed, and it is proposed that telomerase has an important role in the repair of G-rich DNA.
Fair electronic cash withdrawal and change return for wireless networks (2001)

We propose a practical mobile electronic cash system that combines macro and micropayment mechanisms and offers very high security and user's privacy protection. Notably, we have developed an innovative fair withdrawal and change return protocols, which are efficient and preclude any fraudulent misbehaviors, while user anonymity and transaction unlinkability are preserved. Coins are withdrawn if, and only if payer's account is debited. Change is returned to an anonymous payer, who gets it always but only if she is entitled to receive it. Wiretapping of even all channels does not yield a valid coin, and a payment can not be deposited at the account of another payee. Lost or stolen coins are blacklisted immediately and their value is recovered. No cooperation of dishonest participants gives any advantage. A prototype implementation proved that the system is efficient and convenient.
Photoprotection beyond Ultraviolet Radiation – Effective Sun Protection Has to Include Protection against Infrared A Radiation-Induced Skin Damage (2010)

Solar radiation is well known to damage human skin, for example by causing premature skin ageing (i.e. photoageing). We have recently learned that this damage does not result from ultraviolet (UV) radiation alone, but also from longer wavelengths, in particular near-infrared radiation (IRA radiation, 760-1,440 nm). IRA radiation accounts for more than one third of the solar energy that reaches human skin. While infrared radiation of longer wavelengths (IRB and IRC) does not penetrate deeply into the skin, more than 65% of the shorter wavelength (IRA) reaches the dermis. IRA radiation has been demonstrated to alter the collagen equilibrium of the dermal extracellular matrix in at least two ways: (a) by leading to an increased expression of the collagen-degrading enzyme matrix metalloproteinase 1, and (b) by decreasing the de novo synthesis of the collagen itself. IRA radiation exposure therefore induces similar biological effects to UV radiation, but the underlying mechanisms are substantially different, specifically, the cellular response to IRA irradiation involves the mitochondrial electron transport chain. Effective sun protection requires specific strategies to prevent IRA radiation-induced skin damage.
Versatile Mass Spectrometry-Based Intraoperative Diagnosis of Liver Tumor in a Multiethnic Cohort (2022)

Currently used techniques for intraoperative assessment of tumor resection margins are time-consuming and laborious and, more importantly, lack specificity. Moreover, pathological diagnosis during surgery does not often give a clear outcome. Recent advances in mass spectrometry (MS) and instrumentation have made it possible to obtain detailed molecular information from tissue specimens in real-time, with minimal sample pre-treatment. Probe Electro Spray Ionization MS (PESI-MS), combined with artificial intelligence (AI), has demonstrated its effectiveness in distinguishing liver cancer tissues from healthy tissues in a large Italian population group. As the MS profile can reflect the patient’s ethnicity, dietary habits, or particular operating room procedures, the AI algorithm must be well trained to distinguish different groups. We used a large dataset composed of liver tumor and healthy specimens, from the Italian and Japanese populations, to develop a versatile algorithm free from ethnic bias. The system can classify tissues with discrepancies &lt;5% from the pathologist’s diagnosis. These results demonstrate the potential of the PESI-MS system to distinguish tumor from surrounding non-tumor tissues in patients, with minimal bias from race/ethnicity or etiological characteristics or operating room procedures.
Direct Polymer Coating via Polymerization of Gaseous Intermediates (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleDirect Polymer Coating via Polymerization of Gaseous IntermediatesChung J. LeeCite this: Ind. Eng. Chem. Prod. Res. Dev. 1978, 17, 1, 91–92Publication Date (Print):March 1, 1978Publication History Published online1 May 2002Published inissue 1 March 1978https://pubs.acs.org/doi/10.1021/i360065a022https://doi.org/10.1021/i360065a022research-articleACS PublicationsRequest reuse permissionsArticle Views35Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Pathways to Highly Oxidized Products in the Δ3-Carene + OH System (2022)

Oxidation of the monoterpene Δ3-carene (C<sub>10</sub>H<sub>16</sub>) is a potentially important and understudied source of atmospheric secondary organic aerosol (SOA). We present chamber-based measurements of speciated gas and particle phases during photochemical oxidation of Δ3-carene. We find evidence of highly oxidized organic molecules (HOMs) in the gas phase and relatively low-volatility SOA dominated by C<sub>7</sub>-C<sub>10</sub> species. We then use computational methods to develop the first stages of a Δ3-carene photochemical oxidation mechanism and explain some of our measured compositions. We find that alkoxy bond scission of the cyclohexyl ring likely leads to efficient HOM formation, in line with previous studies. We also find a surprising role for the abstraction of primary hydrogens from methyl groups, which has been calculated to be rapid in the α-pinene system, and suggest more research is required to determine if this is more general to other systems and a feature of autoxidation. This work develops a more comprehensive view of Δ3-carene photochemical oxidation products via measurements and lays out a suggested mechanism of oxidation via computationally derived rate coefficients.