gebhart/patrepeval huggingface dataset:
Immunotherapy of Breast with Tumor RNA Transfected Dendritic Cell Vaccines (2001)

Abstract : The major research focus of this grant is to develop effective treatments for patients with low volume metastatic disease using dendritic cell (DC)-based vaccines loaded with tumor RNA. Toward this goal, during the first year of this grant we have made the following progress: (1). We have shown that treatment of DC after transfection with RNA with TNF-alpha: or CD4OL enhances their function as measured by in vitro CTL induction. Based on these observations and pending additional optimizations we plan to incorporate the use of CD4OL treatment in the clinical protocol. (2). We were able to isolate and amplify RNA from frozen tumor sections without apparent loss of function-as indicated by the ability of the amplified RNA to stimulate CTL responses. however, additional studies as outlined in the original grant applications will be necessary to optimize and adapt this strategy for clinical use. Successful RNA amplification may obviate the need of limiting patient accrual to those from whom sufficient cells can be generated (Specific aim #2) and proceed to the more encompassing protocol described in Specific aim #4. (3). We were unsuccessful in obtaining sufficient breast tumor cells for isolation-of sufficient quantities to preclude the need for amplification. We are developing an alternative approach using immunoselection columns in collaboration with Nexcell Therapeutics.
Inductive principles for learning Restricted Boltzmann Machines (2010)

We explore the training and usage of the Restricted Boltzmann Machine for unsupervised feature extraction. We investigate the many different aspects involved in their training, and by applying the concept of iterate averaging we show that it is possible to greatly improve on state of the art algorithms. We also derive estimators based on the principles of pseudo-likelihood, ratio matching, and score matching, and we test them empirically against contrastive divergence, and stochastic maximum likelihood (also known as persistent contrastive divergence). Our results show that ratio matching and score matching are promising approaches to learning Restricted Boltzmann Machines. By applying score matching to the Restricted Boltzmann Machine, we show that training an auto-encoder neural network with a particular kind of regularization function is asymptotically consistent. Finally, we discuss the concept of deep learning and its relationship to training Restricted Boltzmann Machines, and briefly explore the impact of fine-tuning on the parameters and performance of a deep belief network.
Photoisomerization of Aromatic Doramectin Derivatives (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotoisomerization of Aromatic Doramectin DerivativesConstantine Sklavounos, Neil Demers, Joanne Lukaszewicz, and Mark NowakowskiCite this: J. Agric. Food Chem. 1994, 42, 5, 1228–1231Publication Date (Print):May 1, 1994Publication History Published online1 May 2002Published inissue 1 May 1994https://pubs.acs.org/doi/10.1021/jf00041a034https://doi.org/10.1021/jf00041a034research-articleACS PublicationsRequest reuse permissionsArticle Views113Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Formation Mechanism of the Equiaxed Chill Zone in Ingots (1970)

Aluminum oj 99.99% in jJurily, aluminum-tilanium alloys and aluminumcopper alloys were melted in graphile crucibles, and were cooled by placing a cooled iron block on Ihe sUiface oj molten melal. A s Ihe con lent oj titanium or copper increased, an equiaxed chill zone appeared. H owever, no equiaxed chill zone appeared when Ihe alloys were poured inlo slainless sleel cup s and cooled J rom Ihe bottom by waler spray.
The effect of tissue factor pathway inhibitor release and interactions with growth factors on the antitumor effects of ultra low molecular weight heparin semuloparin. (2012)

e13117 Background: Heparins are known to produce anti-tumor effects beside other pharmacologic actions. More recently an ultra LMWH has been developed for the prevention of thrombosis in cancer patients. Initial studies demonstrated that this agent also exhibits anti-tumor effects in animal models. To understand the mechanism of anti-tumor effects of this agent studies were designed to fractionate this ULMWH in to various AT affinity fractions. Methods: An ULMWH (semuloparin, Sanofi-aventis) and its high (HAF) and low (LAF) affinity fractions were prepare by AT affinity chromatography. These agents were administered at 1 mg/kg to primates via intravenous route. Blood samples were collected for a period of up to 6 hours. TFPI release and anti-Xa activities were measured. The interactions of ULMWH and its fractions with various growth factors such as FGF, VEGF, EGF and beta TGF were measured using a mass spectral method employing SELDI technique. The anti-tumor effects of each of these agents were measured using the mouse model of Lewis lung carcinoma. Results: In comparison to ULMWH the LAF showed minimal anti Xa activity whereas HAF exhibited a higher activity. All agents exhibited a similar release of the TFPI; however, HAF exhibited slightly higher release. All agents also showed varying degrees of binding to growth factors as measured by peak intensities. All agents produce anti-tumor effects in the mouse model resulting in a significant reduction in tumor size. Conclusions: Semuloparin has been clinically proven to prevent venous thromboembolism in patients with cancer (SAVE ONCO). These effects are attributable to the inhibition of factor Xa and the generation of thrombin. The fact that LAF mediates its anti-tumor effects without producing anti Xa effects suggest that these may be related to the release of TFPI. Furthermore the ULMWH, HAF and LAF all interact with growth factors suggest that these interactions may also contribute to anti-tumor effects of semuloparin, therefore, beside antithrombotic effects this agent also exhibits oncostatic effects.
Abstract 1200: AXL targeting enhances lymphocyte-mediated cytotoxicity of lung cancer cells (2019)

Abstract As immunotherapies are now used to treat a large proportion of NSCLC patients, defining mechanisms of immune resistance is critical. Immune resistance may arise from both genetic instability and tumor heterogeneity driven by microenvironmental stresses such as hypoxia that promotes carcinoma cell plasticity as well as extrinsic or intrinsic mechanisms of immune resistance. AXL, a member of the TAM receptor tyrosine kinase family is widely expressed human cancers and increasingly recognized for its role in cell plasticity and drug resistance. In this study, we used a model of hypoxia-induced tumor plasticity to generate multiple lung cancer clones with mesenchymal and epithelial features to address mechanisms of immune resistance. We demonstrate that AXL expression is dramatically increased in mesenchymal lung cancer clones. Moreover, expression of AXL in the cells was correlated with an increased cancer cell intrinsic resistance to both NK and CTL-mediated killing, Notably, small molecule AXL targeting potently sensitized mesenchymal lung cancer cells to cytotoxic lymphocyte-mediated killing. Mechanistically, we showed that attenuation of AXL-dependent immune resistance to immune cells involved a novel molecular network comprising NF-κB activation, increased ICAM1 expression, and upregulation of ULBP1 expression coupled with MAPK inhibition. Congruently, higher ICAM1 and ULBP1 tumor expression, correlated with improved patient survival in two NSCLC cohorts. These results reveal a novel AXL-mediated immune escape regulatory pathway, suggest AXL as a novel candidate biomarker for tumor resistance to NK and CTL immunity, and support AXL targeting to optimize immune response in NSCLC. Citation Format: Sallem Chouaib, Stephane Terry, Stephanie Buart, Agnete Engelsen, Gro Gausdal, James Lorens, Jean Paul Thiery, Fathia Mami-Chouaib. AXL targeting enhances lymphocyte-mediated cytotoxicity of lung cancer cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1200.
An Extracellular Subtilase Switch for Immune Priming in Arabidopsis (2013)

In higher eukaryotes, induced resistance associates with acquisition of a priming state of the cells for a more effective activation of innate immunity; however, the nature of the components for mounting this type of immunological memory is not well known. We identified an extracellular subtilase from Arabidopsis, SBT3.3, the overexpression of which enhances innate immune responses while the loss of function compromises them. SBT3.3 expression initiates a durable autoinduction mechanism that promotes chromatin remodeling and activates a salicylic acid(SA)-dependent mechanism of priming of defense genes for amplified response. Moreover, SBT3.3 expression-sensitized plants for enhanced expression of the OXI1 kinase gene and activation of MAP kinases following pathogen attack, providing additional clues for the regulation of immune priming by SBT3.3. Conversely, in sbt3.3 mutant plants pathogen-mediated induction of SA-related defense gene expression is drastically reduced and activation of MAP kinases inhibited. Moreover, chromatin remodeling of defense-related genes normally associated with activation of an immune priming response appear inhibited in sbt3.3 plants, further indicating the importance of the extracellular SBT3.3 subtilase in the establishment of immune priming. Our results also point to an epigenetic control in the regulation of plant immunity, since SBT3.3 is up-regulated and priming activated when epigenetic control is impeded. SBT3.3 represents a new regulator of primed immunity.
In vitro erythrocyte oxidative damage of Morinda citrifolia L (noni) leaves extract (2013)

Slight decrease of hemoglobin and erythrocyte count was observed previously after subchronic oral dosing of Morinda citrifolia L leaves extract in rats. Induction of erythrocyte membrane damage could be the cause for these effects. \nAims: The objective of this investigation was to assess the in vitro cytotoxicity of Morinda citrifolia L leaves extract and fractions on rat erythrocytes. \nMethods: Hemolytic damage was assayed in rat erythrocytes. Oxidative stress was assessed by measuring methemoglobin formation, thiobarbituric acid reactive substances (TBARS) and enzyme antioxidant activities, superoxide dismutase (SOD) and catalase (CAT). \nResults: Morinda citrifolia L extract caused no hemolysis and induced oxidative damage to red cells in vitro. Methemoglobin increase was observed at concentration between 2 and 8 mg/ml of the extract. Lipid peroxidation was increased and CAT and SOD activities were depleted indicating a possible increase of hydrogen peroxide and superoxide radicals in erythrocytes. Ethyl acetate, dichloromethane and butanol fraction did not cause methemoglobin formation while water fraction increased methemoglobin level at doses up to 6 mg/ml. \nConclusions: We concluded that high doses of Morinda citrifolia L extract promote erythrocyte oxidative damage due to metabolites present in water fraction. These could be the cause of decreased erythrocyte and hemoglobin levels observed.\n [J Intercult Ethnopharmacol 2013; 2(3.000): 135-140]
Brazil Restores Democracy (1934)

Essay| September 01 1934 Brazil Restores Democracy Henry Grattan Doyle Henry Grattan Doyle Dean of Columbian College, George Washington University Search for other works by this author on: This Site PubMed Google Scholar Current History (1935) 40 (6): 716–720. https://doi.org/10.1525/curh.1934.40.6.716 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Henry Grattan Doyle; Brazil Restores Democracy. Current History 1 March 1935; 40 (6): 716–720. doi: https://doi.org/10.1525/curh.1934.40.6.716 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentCurrent History Search This content is only available via PDF. © 1934 by The Regents of the University of California1934 Article PDF first page preview Close Modal You do not currently have access to this content.
Superionic Lithium Intercalation through 2 nm x 2 nm Columns in the Crystallographic Shear Phase Nb18W8O69 (2019)

Nb18W8O69 (9Nb2O5×8WO3) is the tungsten-rich end-member of the Wadsley–Roth crystallographic shear (cs) structures within the Nb2O5–WO3 series. It has the largest block size of any known, stable Wadsley–Roth phase, comprising 5 ´ 5 units of corner-shared MO6 octahedra between the shear planes, giving rise to 2 nm ´ 2 nm blocks. Rapid lithium intercalation is observed in this new candidate battery material and 7Li pulsed field gradient nuclear magnetic resonance spectroscopy – measured in a battery electrode for the first time at room temperature – reveals superionic lithium conductivity. In addition to its promising rate capability, Nb18W8O69 adds a piece to the larger picture of our understanding of high-performance Wadsley–Roth complex metal oxides.
Encrypted NFC Emergency Tags Based on the German Telematics Infrastructure (2011)

Patient data, particularly emergency data, must be available to medical personnel within a short time frame and independent of potential interruption of (mobile) network connections. Additionally, medical data is confidential information that must not openly be available to anyone with physical access to the storage media. The planned German electronic Health Card (eHC) is supposed to hold emergency data. However, the eHC smart card will not always be available to caregivers in emergency situations, e.g., unconscious patient, since it cannot be duplicated, customized or read without physical contact. We therefore propose the SemTag prototype which utilizes Near Field Communication (NFC) technology to provide secure and quick access to medical information. Caregivers have the opportunity to store encrypted medical data on tags for a particular group of addressees, e.g., for emergency cases in homecare environments. The tags can be placed on highly visible locations, e.g., entrance areas of homes and carried by the user inform of a token. Neither ubiquitous network access nor the unique eHC is necessary, to view emergency medical data within home care environments. Hence NFC tags can be regarded as a tool for information and identification alternative to distributed information systems for the collaboration of caregivers. This manuscript shows the technical storage and encryption process of emergency data on NFC tags. The technical feasibility, benefits, limitations and future research prospects of the prototype system are discussed.
Gigantic magnetic-field-induced polarization and magnetoelectric coupling in a ferrimagnetic oxide CaBaCo4O7 (2013)

Below ${T}_{C}$, the single-crystal study of CaBaCo${}_{4}$O${}_{7}$, a noncollinear ferrimagnet (${T}_{C}=64$ K) with a polar orthorhombic space group (Pbn2${}_{1}$) between 4 and 293 K, shows a large change in the electric polarization along its $\stackrel{P\vec}{c}$ axis reaching $\ensuremath{\Delta}P=17$ mC/m${}^{2}$ at 10 K. At 62.5 K, a magnetic-field-driven giant variation in polarization $P$(9 T) \ensuremath{-} $P$(0 T) $=$ 8 mC/m${}^{2}$ is observed. Moreover, the present magnetoelectric measurements are fully consistent with the $m$\ensuremath{'}$m$2\ensuremath{'} magnetic point group. This ferrimagnetic oxide, which belongs to the ``114'' structural family, opens an avenue for the search for new magnetoelectrics.
A new omega-conotoxin that targets N-type voltage-sensitive calcium channels with unusual specificity. (2001)

A new specific voltage-sensitive calcium channel (VSCC) blocker has been isolated from the venom of the fish-hunting cone snail Conus consors. This peptide, named omega-Ctx CNVIIA, consists of 27 amino acid residues folded by 3 disulfide bridges. Interestingly, loop 4, which is supposed to be crucial for selectivity, shows an unusual sequence (SSSKGR). The synthesis of the linear peptide was performed using the Fmoc strategy, and the correct folding was achieved in the presence of guanidinium chloride, potassium buffer, and reduced/oxidized glutathione at 4 degrees C for 3 days. Both synthetic and native toxin caused an intense shaking activity, characteristic of omega-conotoxins targeting N-type VSCC when injected intracerebroventricularly to mice. Binding studies on rat brain synaptosomes revealed that the radioiodinated omega-Ctx CNVIIA specifically and reversibly binds to high-affinity sites with a K(d) of 36.3 pM. Its binding is competitive with omega-Ctx MVIIA at low concentration (K(i) = 2 pM). Moreover, omega-Ctx CNVIIA exhibits a clear selectivity for N-type VSCCs versus P/Q-type VSCCs targeted respectively by radioiodinated omega-Ctx GVIA and omega-Ctx MVIIC. Although omega-Ctx CNVIIA clearly blocked N-type Ca(2+) current in chromaffin cells, this toxin did not inhibit acetylcholine release evoked by nerve stimuli at the frog neuromuscular junction, in marked contrast to omega-Ctx GVIA. omega-Ctx CNVIIA thus represents a new selective tool for blocking N-type VSCC that displays a unique pharmacological profile and highlights the diversity of voltage-sensitive Ca(2+) channels in the animal kingdom.
Risk assessment for pharmaceutical products in the environment (2005)

Recently, a Specific Targeted Research Project (STREP), termed F&F,
Symmetric photonic molecules formed from coupled microspheres (2008)

Coherent coupling of optical resonances in spherical microcavities results in the formation of so called photonic molecules. The name originates from the analogy to chemical molecules. The coupled optical modes are similar to the atomic orbitals of a chemical molecule. In this work, we studied the resonance spectrum of the symmetric photonic molecules. Furthermore, symmetric directional emission of light from the photonic molecules is experimentally shown. The photonic molecules are illuminated in the vertical direction with a defocused laser beam. The emission is attributed to photonic nanojets generated in the structure. Spectral analysis exhibit whispering gallery mode resonances of coupled and uncoupled modes. A benzene molecule-like structure consisting of a 7-microspheres cyclic photonic molecule shows a field emission pattern similar to the spatial distribution of the orbitals of the benzene molecule.
INTRAVENOUS USE OF LIDOCAINE FOR VENTRICULAR ARRHYTHMIAS* (1960)

Washington, D.C. *This study was accomplished with the cooperation of the members of the Bailey Thoracic Clinic, Philadelphia, Pennsylvania, and was supported with a grant-in-aid from Astra Pharmaceutical Products, Inc., Worcester, Massachusetts.
Antitumor Therapeutic Strategies Based on the Targeting of Epidermal Growth Factor-Induced Survival Pathways (2005)

Cellular receptors for the Epidermal Growth Factor are considered important targets for the experimental treatment of human cancer. Monoclonal antibodies as well as small tyrosine kinase inhibitors have been developed and have undergone extensive evaluation in preclinical and clinical studies. Most of these studies have been conceived on the general idea that epidermal growth factor receptor (EGFR) plays a critical role on the growth and survival of human tumors. This assumption has been derived by the successful development of BCR/ABL tyrosine kinase inhibitors in human chronic myeloid leukemia as well as on the activity of antiCD20 monoclonal antibodies in lymphoproliferative disease and of anti HER2 agents in breast tumors overexpressing the targeted antigens. It is now becoming clear that factors regulating sensitivity to kinase inhibitors may differ from monoclonal antibodies and that the molecules targeted by interferring drugs must be prioritaire for growth and survival of those specific tumors in order to achieve valuable results. Recent evidence of major responses to the EGFR inhibitor Gefitinib in tumors harboring activating mutations in the EGFR appears on line with this concept. In this article we will discuss the significance of targeting the EGFR driven survival pathways. Specifically, we will afford the point of EGFR survival signalling prioritization by means of pharmacological treatment. Finally, we will address the role of profiling technologies and of novel computational system biology-based approaches for identification of innovative strategies for effective targeting of EGFR driven survival pathways. Keywords: egfr, molecular targeting, survival pathways, Interferon, apoptosis, cellular stress, target prioritization
Application of High-Resolution MALDI-TOFMS with a Spiral Ion Trajectory for the Structural Characterization of Free Radical Polymerized Methacrylate Ester Copolymers (2013)

The structural characterization of copolymers by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) remains a challenging task, since their random comonomer distribution creates very complicated mass spectra. In this study, a high-resolution TOF mass spectrometer with a spiral ion trajectory was applied to the structural and compositional characterization of free radical copolymerized poly(methyl methacrylate-co-tert-butyl methacrylate), poly(MMA-co-tBMA)s in ethyl lactate acting as a chain transfer agent. Virtually complete peak assignments of the isobaric components within the poly(MMA-co-tBMA)s served to identify the end-group combinations and copolymer compositions of individual copolymer components, allowing the distributions of comonomer compositions and six types of end-group combinations to be evaluated.
In situ Interparticle Resistance Measurements for Materials of Relevance to Battery Applications (2006)

Abstract not Available.