gebhart/patrepeval huggingface dataset:
Sorting and separation of microparticles by surface properties using liquid crystal-enabled electro-osmosis (2018)

Sorting and separation of microparticles is a challenging problem of interdisciplinary nature. Existing technologies can differentiate microparticles by their bulk properties, such as size, density, electric polarisability, etc. The next level of challenge is to separate particles that show identical bulk properties and differ only in subtle surface features, such as functionalisation with ligands. In this work, we propose a technique to sort and separate particles and fluid droplets that differ in surface properties. As a dispersive medium, we use a nematic liquid crystal (LC) rather than an isotropic fluid, which allows us to amplify the difference in surface properties through distinct perturbations of LC order around the dispersed particles. The particles are placed in an LC cell with spatially distorted molecular orientation subject to an alternating current electric field. The gradients of the molecular orientation perform two functions. First, elastic interactions between these pre-imposed gradients and distortions around the particles separate the particles with different surface properties in space. Second, these pre-imposed patterns create electro-osmotic flows powered by the electric field that transport the sorted particles to different locations thus separating them. The demonstrated unique sorting and separation capability opens opportunities in lab-on-a-chip, cell sorting and bio-sensing applications.
Photosubstitution reactivity of a series of pentacarbonylpyridinotungsten(0) complexes having ligand field or charge-transfer lowest excited states (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotosubstitution reactivity of a series of pentacarbonylpyridinotungsten(0) complexes having ligand field or charge-transfer lowest excited statesMark S. Wrighton, Harmon B. Abrahamson, and David L. MorseCite this: J. Am. Chem. Soc. 1976, 98, 14, 4105–4109Publication Date (Print):July 1, 1976Publication History Published online1 May 2002Published inissue 1 July 1976https://pubs.acs.org/doi/10.1021/ja00430a016https://doi.org/10.1021/ja00430a016research-articleACS PublicationsRequest reuse permissionsArticle Views178Altmetric-Citations88LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Synthesis and Structure of Complexes of Np(V) Benzoate, o-Fluorobenzoate, and p-Fluorobenzoate with 1,10-Phenanthroline (2019)

The structures of three new Np(V) complexes [(NpO2)2(phen)2(C7H5O2)2] (I), [(NpO2)2(phen)2. (o-C7H4FO2)2] (II), and [(NpO2)2(phen)2(p-C7H4FO2)2] (III), where phen = 1,10-phenanthroline, were studied. Two NpO2+ cations in the complexes are bound to each other by cation-cation bonds in which both neptunyl(V) ions act with respect to each other as lignads and as coordination centers simultaneously, forming dimeric An2O42+ cations. In complexes I–III, each Np atom has the coordination polyhedron (CP) in the form of a pentagonal bipyramid with the “yl” O atoms in the apical positions; the neptunyl(V) groups are appreciably nonlinear. The equatorial plane of the bipyramids is constituted by two N atoms of phenanthroline, O atom of the other NpO2+ cation, and two O atoms of the C6H5COO- (I), o-C6H4FCOO- (II), and p-C6H4FCOO- (III) anions. The Np⋅⋅⋅Np interatomic distances in the dimetic NpO2+ cations (Å) are 3.40519(17) (I), 3.43891(17) (II), and 3.4271(3) (III). The main differences in the structures of I–III are manifested in the conformational characteristics and are caused by the effect of C-H⋅⋅⋅O and C-H⋅⋅⋅F hydrogen bonding.
Cysteine and glutathione concentrations in plasma and bronchoalveolar lavage fluid after treatment with N-acetylcysteine. (1991)

N-acetylcysteine (600 mg/day) was given to patients by mouth for five days before bronchoscopy and bronchoalveolar lavage to determine whether N-acetylcysteine could increase the concentrations of the antioxidant reduced glutathione in plasma and bronchoalveolar lavage fluid. Bronchoalveolar lavage was performed 1-3 hours (group 2, n = 9) and 16-20 hours (group 3, n = 10) after the last dose of N-acetylcysteine and the values were compared with those in a control group receiving no N-acetylcysteine (group 1, n = 8). N-acetylcysteine was not detected in plasma or lavage fluid. Plasma concentrations of cysteine, the main metabolite of N-acetylcysteine and a precursor of reduced glutathione, were greater in the groups receiving treatment (groups 2 and 3) than in group 1. Cysteine concentrations in lavage fluid were similar in the three groups. Concentrations of reduced glutathione were greater in both plasma and lavage fluid in group 2 than in group 1. These data suggest that N-acetylcysteine given by mouth is rapidly deacetylated to cysteine, with resulting increases in the concentrations of cysteine in plasma and of reduced glutathione in plasma and the airways, which thus temporarily increase the antioxidant capacity of the lung.
Quadratic Memory is Necessary for Optimal Query Complexity in Convex Optimization: Center-of-Mass is Pareto-Optimal (2023)

We give query complexity lower bounds for convex optimization and the related feasibility problem. We show that quadratic memory is necessary to achieve the optimal oracle complexity for first-order convex optimization. In particular, this shows that center-of-mass cutting-planes algorithms in dimension $d$ which use $\tilde O(d^2)$ memory and $\tilde O(d)$ queries are Pareto-optimal for both convex optimization and the feasibility problem, up to logarithmic factors. Precisely, we prove that to minimize $1$-Lipschitz convex functions over the unit ball to $1/d^4$ accuracy, any deterministic first-order algorithms using at most $d^{2-δ}$ bits of memory must make $\tildeΩ(d^{1+δ/3})$ queries, for any $δ\in[0,1]$. For the feasibility problem, in which an algorithm only has access to a separation oracle, we show a stronger trade-off: for at most $d^{2-δ}$ memory, the number of queries required is $\tildeΩ(d^{1+δ})$. This resolves a COLT 2019 open problem of Woodworth and Srebro.
Genetic basis of pain variability: recent advances (2011)

An estimated 15-50% of the population experiences pain at any given time, at great personal and societal cost. Pain is the most common reason patients seek medical attention, and there is a high degree of individual variability in reporting the incidence and severity of symptoms. Research suggests that pain sensitivity and risk for chronic pain are complex heritable traits of polygenic origin. Animal studies and candidate gene testing in humans have provided some progress in understanding the heritability of pain, but the application of the genome-wide association methodology offers a new tool for further elucidating the genetic contributions to normal pain responding and pain in clinical populations. Although the determination of the genetics of pain is still in its infancy, it is clear that a number of genes play a critical role in determining pain sensitivity or susceptibility to chronic pain. This review presents an update of the most recent findings that associate genetic variation with variability in pain and an overview of the candidate genes with the highest translational potential.
Boundary-Aware Salient Object Detection via Recurrent Two-Stream Guided Refinement Network (2019)

Recent deep learning based salient object detection methods which utilize both saliency and boundary features have achieved remarkable performance. However, most of them ignore the complementarity between saliency features and boundary features, thus get worse predictions in scenes with low contrast between foreground and background. To address this issue, we propose a novel Recurrent Two-Stream Guided Refinement Network (RTGRNet) that consists of iterating Two-Stream Guided Refinement Modules (TGRMs). TGRM consists of a Guide Block and two feature streams: saliency and boundary, the Guide Block utilizes the refined features after previous TGRM to further improve the performance of two feature streams in current TGRM. Meanwhile, the low-level integrated features are also utilized as a reference to get better details. Finally, we progressively refine these features by recurrently stacking more TGRMs. Extensive experiments on six public datasets show that our proposed RTGRNet achieves the state-of-the-art performance in salient object detection.
Adult progenitor cells in vascular remodeling during atherosclerosis (2008)

The mobilization and recruitment of bone marrow-derived, circulating or tissue resident progenitor cells giving rise to smooth muscle-like cells have been implicated in neointima hyperplasia after arterial injury and in accelerated forms of arterial lesion formation, e.g., transplant arteriopathy or graft vasculopathy. By contrast, convincing evidence has emerged that the vascular homing of endothelial progenitor cells (EPCs) contributes to endothelial recovery, thus limiting neointima formation after arterial injury. In the chronic context of primary atherosclerosis, plaque progression and destabilization, a more complex picture has become apparent. In patients with coronary artery disease, the number and function of EPCs have been linked with an improved endothelial function or regeneration, but have been inversely correlated with cardiovascular risk. In animal models, however, the injection of bone marrow cells or EPCs, or the application of stem-cell mobilizing factors, have been associated with an exacerbation of atherosclerosis and unstable plaque phenotypes, whereas the contribution of bone marrow-derived smooth muscle progenitors to primary atherosclerosis appears to be rather confined. Here, we discuss crucial biochemical cues, namely chemokines, adhesion molecules, growth factors and pharmacological means that guide and control the context-specific mobilization, recruitment and fate of vascular progenitor cells in arterial remodeling during atherosclerosis.
A modeling study to estimate prostate cancer‐specific mortality on active surveillance for men with favorable intermediate‐risk prostate cancer: Results from the SEARCH cohort (2023)

The risk of death for FIR after RP is very low. Assuming even modestly increased PCSM with AS versus RP, the excess risk of death for AS in FIR is low even up to 15 years. These data support the consideration of AS as a relatively safe alternative to RP in FIR men, though prospective randomized trials are needed to validate these findings.
Suppressing effect of sorbitol on dissociation of carp myosin B into actin and myosin induced by high concentration of salt. (1990)

Carp myosin B(2-3mg/ml) was treated at 10°C with 2.OM NaCl or KCl in the presence of various concentrations of sorbitol. During the treatment of myosin B, changes in ATP sensitivity, the amount of denatured actin, and thermal inactivation mode of Ca-ATPase were investigated with a lapse of time. The ATP sensitivity irreversibly decreased and denatured actin increased with the duration of salt treatment. Thermal inactivation mode of Ca-ATPase changed from a single first order step to a biphasic first order process by the salt treatment. The changes induced by NaCl were relatively larger than those by KCl, and sorbitol reduced these changes. After the treatment with 2.0M NaCl for 3h, dissociation of myosin from myosin B was recognized by ultracentrifugal sedimentation analysis and gel filtration profile on Sepharose-CL-4B followed by SDS-polyacrylamide gel electrophoretic analysis, and such salt-induced production of myosin monomer was also reduced by the treatment in the presence of sorbitol. These results showed that sorbitol suppressed the dissociation of myosin B into actin and myosin induced by high concentration of salt.
Social Media and Relationships (2015)

Abstract This entry focuses on the ways in which social media systems are affected by and affect relationships. No matter what the underlying technology, the power of social media systems arises from the impact they have on relationships. Whether in friendship and dating relationships or professional and work relationships, social media use shapes and is shaped by how individuals see their relationships, who they have relationships with, and how those relationships are formed, maintained, and ended.
Analysis of the Normalized LMS Optimum Solution in the Context of Channel Equalization (2018)

Albeit being presented as an alternative to the classical least-mean-square (LMS) algorithm, the normalized LMS (NLMS) actually deals with a modified mean squared error (MSE) cost function, so that the expected optimum solution may differ from the Wiener solution. In this work, we perform an investigation concerning the question as to whether such difference may arise in the context of the channel equalization problem by considering a representative set of transmitted signal modulations, channel models and signal-to-noise ratio (SNR) conditions. Additionally, we analyze the influence of the potential deviation from the optimal solution on the performance of the equalizer.
Power devices for high voltage integrated circuits: new device and technology concepts (2002)

Power electronic devices and power integrated circuits will play a crucial role in increasing the efficiency with which electric power is consumed. This paper is concerned with recent trends in high voltage devices for integrated circuits and prospective industrial applications of high voltage power integrated circuits. New device concepts are explored in comparison with classical LDMOSFETs and LIGBTs. Alternative technologies to the conventional junction-isolation technology, such as high voltage SOI technology are also briefly analysed.
Single-kernel Analysis for the Presence of the sugary enhancer (se) Gene in Sweet Corn (1988)

Abstract This paper presents the methodology for the extraction and quantitative analysis of the sugars from single kernels of maize ( Zea mays L. var. saccharata Bailey). Concentrations of sorbitol, fructose, glucose, sucrose, and maltose were determined for individual kernels of sweet corn inbreds homozygous for the endosperm carbohydrate mutants sugary (su) and sugary enhancer (se) by gas chromatographic analysis. The extraction procedure was efficient and precise. Single-seed sugar analysis of kernels from the inbreds IL451b (su) and IL677a (su se) revealed that genetic differences between the inbreds was the primary source of phenotypic variation in kernel sugar content. Differences between ears of the same inbred was also a significant source of variation, whereas, in most instances, kernel-to-kernel variation on ears was not. Fifty-eight percent of the variation in the predominant corn sugar, sucrose, was attributed to genetic differences between the two inbreds. Analysis of the observed and predicted distribution in a mature-dry F 2 kernel population for sucrose content indicated that single-kernel analysis can isolate the action of the se gene in segregating populations. This procedure can be used to simplify the incorporation of se into elite inbreds, map its chromosomal location, and uncover other potentially useful alleles that modify corn endosperm carbohydrate metabolism.
HPV infections in the dermatovenerological practice (2021)

HPV associated diseases, which may range from banal conditions through sexually transmitted infections to malignant illnesses, are highly prevalent in the everyday dermatological practice. Our aim in this paper is to summarize the variety of their appearance and the possibilities of diagnostics and therapy.
Regulation of thyroid hormone activation via the liver X-receptor/retinoid X-receptor pathway (2010)

Thyroid hormone receptor (TR) and liver X-receptor (LXR) are the master regulators of lipid metabolism. Remarkably, a mouse with a targeted deletion of both LXR alpha and LXR beta is resistant to western diet-induced obesity, and exhibits ectopic liver expression of the thyroid hormone activating type 2 deiodinase (D2). We hypothesized that LXR/retinoid X-receptor (RXR) signaling inhibits hepatic D2 expression, and studied this using a luciferase reporter containing the human DIO2 (hDIO2) promoter in HepG2 cells. Given that, in contrast to mammals, the chicken liver normally expresses D2, the chicken DIO2 (cDIO2) promoter was also studied. 22(R)-OH-cholesterol negatively regulated hDIO2 in a dose-dependent manner (100 microM, approximately twofold), while it failed to affect the cDIO2 promoter. Truncations in the hDIO2 promoter identified the region -901 to -584 bp as critical for negative regulation. We also investigated if 9-cis retinoic acid (9-cis RA), the ligand for the heterodimeric partner of TR and LXR, RXR, could regulate the hDIO2 promoter. Notably, 9-cis RA repressed the hDIO2 luciferase reporter (1 microM, approximately fourfold) in a dose-dependent manner, while coexpression of an inactive mutant RXR abolished this effect. However, it is unlikely that RXR homodimers mediate the repression of hDIO2 since mutagenesis of a DR-1 at -506 bp did not interfere with 9-cis RA-mediated repression. Our data indicate that hDIO2 transcription is negatively regulated by both 22(R)-OH-cholesterol and 9-cis RA, which is consistent with LXR/RXR involvement. In vivo, the inhibition of D2-mediated tri-iodothyronine (T(3)) production by cholesterol/9-cis RA could function as a feedback loop, given that T(3) decreases hepatic cholesterol levels.
Abstract 4915: Preclinical pharmacology and toxicology of intravenous BPM31510, a coenzyme Q10-containing lipid nanodispersion (2018)

Abstract Coenzyme Q10 (CoQ10) plays an important role in cellular metabolism with redox capabilities beyond the mitochondria. Although, the role of CoQ10 in providing benefit in diseases such as cardiovascular, neurodegeneration, and cancer is well established, it has been limited by the absence of delivery methods to achieve physiologically relevant bio-availability. BPM31510 is a CoQ10 (ubidecarenone) containing lipid nanodispersion that delivers supraphysiological concentrations of CoQ10 to tissues, cells and mitochondria. BPM31510 is currently in clinical trials for the treatment of solid tumors including pancreatic cancer and glioblastoma multiforme. This study describes the preclinical pharmacokinetic (PK) and toxicokinetic assessment of BPM31510 (62.5, 125, and 250 mg/kg) after acute (single) intravenous (IV) administration and chronic (3 times a week for 4 weeks), and after a two week recovery from the last exposure in rats. Here, it was demonstrated that the formulation enables an effective delivery of CoQ10 with a robust increase in plasma level and dose-dependent accumulation in several tissues. PK analysis of mean plasma concentration of CoQ10 after a single and repeat dose administration revealed a dose proportion effect on peak (Cmax) and total exposure (AUC0-t). Tissue analysis of CoQ10 levels demonstrates a dose-dependent increase in liver, lung and pancreas 72 hours post-last dose. A dose dependent elimination was observed in both male and females. No difference in pharmacokinetic of CoQ10 using this formulation was observed between males and females. Notably, chronic exposure to BPM31510 does not lead to toxicities as assessed by hematology and coagulation, clinical chemistry, histopathology and gross necropsy. These results indicate that the effective delivery and bioavailability of supraphysiological levels of CoQ10 after IV administration of BPM31510 is well tolerated. Citation Format: David Linsenmayer, Shiva Kazerounian, Khampaseuth Thapa, Carrie Spencer, Aishwarya Sarma, John McCook, Stephane Gesta, Vivek Vishnudas, Niven R. Narain, Rangaprasad Sarangarajan. Preclinical pharmacology and toxicology of intravenous BPM31510, a coenzyme Q10-containing lipid nanodispersion [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 4915.
SONYC Urban Sound Tagging (SONYC-UST): A Multilabel Dataset from an Urban Acoustic Sensor Network (2019)

SONYC Urban Sound Tagging (SONYC-UST) is a dataset for the development and evaluation of machine listening systems for realworld urban noise monitoring. It consists of 3068 audio recordings from the "Sounds of New York City" (SONYC) acoustic sensor network. Via the Zooniverse citizen science platform, volunteers tagged the presence of 23 fine-grained classes that were chosen in consultation with the New York City Department of Environmental Protection. These 23 fine-grained classes can be grouped into eight coarse-grained classes. In this work, we describe the collection of this dataset, metrics used to evaluate tagging systems, and the results of a simple baseline model.
The Early Intestinal Microbiota of Healthy Korean Newborns (2015)

This study confirms that bacterial colonization of healthy newborns born in cities is non-sterile, but has early diversification and inter-individuality.
[Inhibitor interneurons of horizontal ocular saccades studied in the alert cat with the aid of intra-axonal injections of peroxidase]. (1980)

A simultaneous study of the functional and morphological characteristics of burst inhibitory neurons (B.I.N.) has been performed in the alert cat. For the first time, in the central nervous system of mammal, extra- and intracellular records have been coupled with intra-axonal injection of H.R.P. in the alert animal. The B.I.N. discharge during saccades and the quick phase of vestibular and optokinetic nystagmus oriented toward the ipsilateral side of recording. The frequency of discharges is proportional to the eye angular velocity. The axons end on the abducens motoneuron. Collaterals reach the controlateral prepositus hypoglossi nucleus, medial vestibular nucleus and reticular nuclei.
In Vivo Therapeutic Potential of Mesenchymal Stromal Cells Depends on the Source and the Isolation Procedure (2015)

Over the last several years, mesenchymal stromal cells (MSCs) have been isolated from different tissues following a variety of different procedures. Here, we comparatively assess the ex vivo and in vivo properties of MSCs isolated from either adipose tissue or bone marrow by different purification protocols. After MSC transplantation into a mouse model of hindlimb ischemia, clinical and histological analysis revealed that bone marrow MSCs purified on adhesive substrates exerted the best therapeutic activity, preserving tissue viability and promoting formation of new arterioles without directly transdifferentiating into vascular cells. In keeping with these observations, these cells abundantly expressed cytokines involved in vessel maturation and cell retention. These findings indicate that the choice of MSC source and purification protocol is critical in determining the therapeutic potential of these cells and warrant the standardization of an optimal MSC isolation procedure in order to select the best conditions to move forward to more effective clinical experimentation.
Nanowires as Building Blocks of New Devices: Present State and Prospects (2010)

This chapter contains sections titled: Introduction On the Advantages of Individual Nanowire-Based Devices Towards Real Devices Future Challenges Conclusion