gebhart/patrepeval huggingface dataset:
Evaluation and Development of Pavement Scores, Performance Models and Needs Estimates for the TxDOT Pavement Management Information System - Final Report (2012)

This project conducted a thorough review of the existing Pavement Management Information System (PMIS) database, performance models, needs estimates, utility curves, and scores calculations, as well as a review of District practices concerning the three broad pavement types, asphalt concrete pavement, jointed concrete pavement, and continuously reinforced concrete pavement. The proposed updates to the performance models, utility curves, and decisions trees are intended to improve PMIS scores and needs estimates so that they more accurately reflect District opinions and practices, and reduce performance prediction errors. Researchers hope that implementation of these PMIS modifications will improve its effectiveness as a decision-aid tool for the Districts. Appendices H, J, and K contain calibrated PMIS performance model coefficients for asphalt concrete pavement (ACP), continuously reinforced concrete pavement (CRCP), and jointed concrete pavement (JCP), respectively; they are recommended for use in the existing PMIS performance models (summarized in Chapter 4). Appendices M and N contain new revised utility curves and coefficients for ACP, CRCP, and JCP pavement distresses. Appendices T, U, and V contain revised ACP, CRCP, and JCP decision trees for needs estimates determination. Appendix Z contains a recommended priority index that can be used for programming projects for preservation, rehabilitation, and reconstruction.
Dual-Surface input (2009)

Interaction patterns with handheld mobile devices are constantly evolving. Researchers observed that users prefer to interact with mobile device using one hand. However, only few interaction techniques support this mode of operation. We show that one-handed operations can be enhanced with coordinated interaction using for input the front and back of a mobile device, which we term as Dual-Surface interaction. We present some of the design rationale for introducing coordinated Dual-Surface interactions. We demonstrate that several tasks, including target selection, benefit from Dual-Surface input which allows users to rapidly select small targets in locations that are less accessible when interacting using the thumb with one-handed input. Furthermore, we demonstrate the benefits of virtual enhancements that are possible with behind-the-display relative input to perform complex tasks, such as steering. Our results show that Dual-Surface interactions offer numerous benefits that are not available with input on the front or the back alone.
Immunization Studies with Living Vaccine of Salmonella typhimurium. (1960)

A streptomycin-dependent mutant was isolated from a virulent strain of S. typhimurium for evaluation as a living vaccine in mice. In vivo and in vitro studies indicated that this strain was unsafe as an immunizing agent due to reversions to streptomycin independence. A mutant of the streptomycin-dependent strain was obtained requiring purine, a nutritional factor absent in mouse peritoneum. Reversions of this double mutant strain to the purine-streptomycin-independent state could not be detected. The results of experiments comparing this living vaccine with heat-killed preparation indicated that the living vaccine was not superior in protecting mice.
Synthesis and smooth muscle relaxant activity of a new series of potassium channel activators: 3-amido-1,1-dimethylindan-2-ols (1991)

The synthesis of a novel series of smooth muscle relaxants which have been shown to act via the opening or activation of potassium channels is described. Compounds have been evaluated for their ability to inhibit spontaneous tone in guinea pig isolated trachealis and structure-activity relationships are discussed. One compound in particular, 1,1-dimethyl-5-nitro-3-(2-pyridon-1-yl)indan-2-ol, (16) was identified as a potent relaxant of airways smooth muscle in vitro with IC50 = 0.15 microM and was found to significantly inhibit histamine-induced dyspnoea in conscious guinea pigs when given orally 30-45 min prior to challenge.
Markdowns in Seasonal Conspicuous Goods (2019)

In common parlance, luxury and markdowns are, in many respects, contradictory concepts. Markdowns decrease product exclusivity and hence consumers’ willingness to pay (i.e., snob effect) since most consumers purchasing luxury desire uniqueness. Markdowns also encourage strategic (forward-looking) consumers to wait for lower prices (i.e., strategic effect). Yet, luxury retailers frequently adopt markdowns in practice to stimulate the demand for their seasonal products (i.e., sales effect). To study the impact of these three countervailing effects on a luxury retailer’s markdown policy and rationing strategy, this paper develops a game-theoretic model with strategic and exclusivity-seeking consumers who have heterogeneous (high and low) valuations. We characterize a luxury retailer’s equilibrium markdown and rationing strategies, and find that the retailer induces a buying frenzy (i.e., selling deliberately less than the demand) to increase consumers’ willingness to pay when they are sufficiently exclusivity-seeking. We show that the retailer’s markdown policy depends on consumers’ desire for exclusivity when the proportion of consumers with high valuation is not too high or too low. Interestingly, we find that, in such cases, consumers’ higher desire for exclusivity does not motivate the retailer to increase exclusivity and to adopt uniform pricing. To the contrary, it motivates the retailer to decrease the exclusivity and to adopt markdowns. By doing so, we identify exclusivity-seeking consumer behavior as another rationale behind markdown pricing. Lastly, we find that, when selling to exclusivity-seeking consumers, the negative impact of strategic consumer behavior is lower; however, ignoring it can be more costly.
A SURVEY ON 3D HUMAN BODY MODELING FOR INTERACTIVE FASHION DESIGN (2013)

With the advancement in computer technology, the use of 3D virtual mannequin has mostly replaced the use of physical mannequin in the fashion industry. This paper reviews current interaction frameworks of 3D human body modeling for interactive fashion design and an optimized interaction framework is provided. Four methods are used in this study to collect the human body data to create the 3D body model: photograph-based method, laser scan method, feature curve method and combined method. The crafted garment modeling could be used for garment fitting and 2D pattern flattening.
Imaging growth as a predictor of grade of malignancy and aggressiveness of IDH-mutant and 1p/19q-codeleted oligodendrogliomas in adults (2020)

The spontaneous tumor growth rate recapitulates oligodendroglioma aggressiveness, permits identification of grade III oligodendrogliomas preoperatively when ≥8 mm/year, and questions the grading by mitosis count.
ONE-PORT 25-GAUGE PARS PLANA VITRECTOMY WITH INDIRECT OPHTHALMOSCOPY FOR TREATMENT OF ENDOPHTHALMITIS (2008)

One-port 25-gauge pars plana vitrectomy with indirect ophthalmoscopy is both safe and practical for core vitrectomy in endophthalmitis.
ChemInform Abstract: Synthesis of d,l‐Norlabdane Oxide and Related Odorants: An Intramolecular Radical Approach. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Experimental and mechanism study: Partially hydrolyzed polyacrylamide gel degradation and deplugging via ultrasonic waves and chemical agents (2019)

Partially hydrolyzed Polyacrylamide (PHPAM) crosslinked by Cr<sup>+3</sup> is frequently applied to plug thief zone for the better water management in matured oil reservoir. However, PHPAM gel may certainly cause inevitable formation damage nearby the wellbore. Although various kinds of chemical agents, such as hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>), sodium hypochlorite (NaOCl), and chlorine dioxide (ClO<sub>2</sub>) were employed to mitigate the nearby wellbore damage. But, huge financial investment, poor degelation efficiency, environmentally insecure, corrosion problem, and long time span requirement persuade researchers to look for other effective technique. In this connection, ultrasonic waves is characterized by reliable, environment friendly, and cost effective technology. Current work involves comparative study of PHPAM gel degradation by the individual means of chemical agent and ultrasonic waves. Subsequently, the best-performed ultrasonic parameters and well-performed chemical agent were used independently and then simultaneously to deplug (PHPAM gel) the core sample. Results showed that 20 KHz frequency (1000 W) effectively reduced gel viscosity from original (2495 mPa.s) to 1.37 mPa.s after 10 min irradiation. This degradation is attributed to cavitation, heat energy, and hydroxyl radical (HO∙). However, after 2 min further exposure, the viscosity grew back to 3.29 mPa.s (18 KHz), 1.42 mPa.s (20 KHz), and 3.74 mPa.s (25 KHz). This adverse behavior is owing to hydroxyl radical (HO∙) annihilation. In chemical treatment, H<sub>2</sub>O<sub>2</sub> among other chemicals efficiently degelled the PHPAM gel's original viscosity to 2.64 mPa.s after 24 h reaction. Similarly, NaOCl and ClO<sub>2</sub> brought down original viscosity to 6.5 mPa.s and 159 mPa.s respectively. SEM of the samples before and after treatment was performed for the better understanding of PHPAM gel morphology. Considering dynamic experiment, maximum 23.5% and 19.80% damaged permeability recovery (30 × 10<sup>-3</sup> μm<sup>2</sup> gas permeability) were obtained by applying ultrasonic waves (20 KHz, 1000 W, and 100 min irradiation) and chemical agent (H<sub>2</sub>O<sub>2</sub>) respectively. Permeability recovery was further increased to 40.90% by the simultaneous application of ultrasonic waves and chemical agent.
IDENTIFICATION OF PANCREATIC CANCER STEM CELLS (2005)

Introduction: Emerging evidence has shown that the capacity of a tumor to grow and propagate is dependent on a small subset of cells within a tumor, termed cancer stem cells. While strong data has been provided to support this theory in blood, brain, and breast cancers, the presence of pancreatic cancer stem cells has not been studied. We hypothesized that a small subset of cells within pancreatic cancers possess a “stem cell” phenotype and are responsible for pancreatic cancer growth. Methods: Eight xenografts of human pancreatic adenocarcinoma (2 met, 6 primary) were established in the flank of NOD-SCID mice. After establishment of tumors, studies were performed on passage 1-2 of tumors. For sorting of putative cancer stem cells, xenografts were digested with ultra-pure collagenase III in medium 199, and contaminating mouse cells were removed by sorting using the mouse H2K marker, followed by double sorting for the markers CD44, CD24, and ESA. Sorted and unsorted cells were then suspended in serum free-RPMI/Matrigel mixture (1:1 volume) and injected into NOD/SCID mice. Bioluminescent imaging was also performed in sorted cells infected with a lentivirus expressing luciferase in an orthotopic tumor model. Results: The stem cells markers CD44, CD24, and ESA were each expressed in 3-8% of cells from established tumors. The percentage of cancer cells expressing these stem cell markers was maintained upon passaging. In a dose response of unsorted cells (100-100K), no tumor growth was evident at 12 weeks unless at least 50K cells were implanted. In contrast, 6/9 animals implanted with 500 ESA+ cells and 3/11 animals implanted with 500 ESA+CD44+ cells had large tumors evident at 12 weeks, a 100-fold increase in tumorigenic potential. In the bioluminescent orthotopic model, implantation of 5000 ESA+ cells in the tail of the pancreas resulted in the formation of tumors (evident at 21 days), while none were observed in animals injected with ESA-cells. Conclusion: A putative cancer stem cell population has been identified in human pancreatic adenocarcinomas. Further characterization of this cancer stem cell population may allow development of therapeutic strategies to selectively target this cell population, which has been shown in other tumor models to be highly resistant to standard therapies.
Tissue distribution of murine hemopoietic growth factor mRNA production (1989)

We have studied the tissue distribution of interleukin (IL) and hemopoietic colony-stimulating factor (CSF) transcripts in mice by S1-nuclease protection analysis. Accumulation of several of these mRNAs in response to intravenous injection of lipopolysaccharide (LPS) appears to occur in a tissue-specific fashion. IL-1 alpha transcripts accumulate in spleen and lung; IL-6 transcripts accumulate in kidney, heart, and spleen; granulocyte-macrophage-CSF transcripts accumulate in lung and heart; and granulocyte-CSF transcripts accumulate in heart. Three distinct patterns of in vivo mRNA accumulation were detected: 1) silent--interleukins 2-5 showed no transcripts in either LPS-treated or untreated animals; 2) induced--IL-1 alpha, IL-6, granulocyte-macrophage (GM)-CSF, and G-CSF transcripts were increased in abundance in LPS-injected mice; and 3) constitutive--M-CSF transcripts were found in similar amounts in both untreated and treated mice and were present in all tissues examined.
Efficient marker-based recurrent selection for multiple quantitative trait loci (2000)

International audience
Multidimensional NMR spectroscopy for the study of histone H4–Ni(ii) interaction (2006)

The N-terminal 30-amino acid tail of histone H4, a nuclear protein, was studied as a model for the interaction of this protein with Ni(ii) ions. The behaviour of the ends-blocked Ac-SGRGKGGKGLGKGGA(15)K(16)R(17)H(18)R(19)KVLRDNIQGIT-Am fragment towards Ni(ii) was analyzed with multidimensional NMR (1D, 2D TOCSY, NOESY) and UV-Vis spectroscopy. As expected, the coordination involved the imidazolic nitrogen of the His(18) residue and the three deprotonated amidic nitrogens of the His(18), Arg(17) and Lys(16) residues, respectively. A model for the structure of the complex was calculated from the inter-residual NOEs recorded in 2D NOESY spectra. The structure obtained shows that the interaction with the metal is responsible for deep changes in the conformation of the peptide, blocking the side chain of Arg(17) and Lys(16) residues above the coordination plane. These structural modifications may be physiologically relevant to the mechanism of nickel carcinogenesis.
Effects of intracardiac bradykinin and capsaicin on spinal and spinoreticular neurons (1989)

The responses of thoracic spinal and spinoreticular tract (SRT) neurons to activation of cardiac spinal afferents by injections of bradykinin (BK) and capsaicin (CAP) into the left atrium or pericardial sac were determined in vagotomized cats anesthetized with alpha-chloralose. Activities of spinal and SRT neurons in the T1-T5 spinal cord were recorded extracellularly. All neurons received excitatory somatic and cardiopulmonary sympathetic afferent input. Application of BK and CAP to the heart excited most SRT neurons and many spinal neurons but also inhibited some spinal neurons. The two drugs often affected spinal but not SRT neurons differently. Capsaicin excited high threshold and high threshold inhibitory neurons but not wide-dynamic range spinal neurons. In contrast, BK excited all three categories of spinal and SRT neurons. The differential responses of spinal neurons to intracardiac BK and CAP suggested that these compounds can stimulate functionally different populations of cardiac sympathetic afferents.
Electrical and optical properties ofFeCl3-doped polyparaphenylene [(p-C6H4)x] (1985)

The results of an experimental study of dc and microwave electrical conductivities, electron-spin resonance, optical reflection, and infrared absorption in ${\mathrm{FeCl}}_{3}$-doped polyparaphenylene (PPP) are presented. In low-conducting PPP, the conductivity is described by interpolaron hopping processes among the polaron and bipolaron states induced by the doping. Further evidence for these states is obtained from the ir and ESR results in doped PPP. The new infrared modes due to doping and the behavior of the spin density as a function of the dopant concentration can be accounted for by the formation of polarons and spinless bipolarons. The pronounced plasma edge in the reflection spectra of heavily doped samples points to an inhomogeneous material and the existence of strands with high charge-carrier concentrations, whereas the dc conductivity can be well described by variable-range hopping processes occurring within the regions between the strands.
A randomized controlled clinical trial of topical insulin-like growth factor-1 therapy for sudden deafness refractory to systemic corticosteroid treatment (2014)

UMIN Clinical Trials Registry Number UMIN000004366, October 30th, 2010.
Synthese des Flechtenmakrolids (+)‐Aspicilin mit Photolactonisierung als Schlüsselreaktion (1988)

Synthesis of the Lichen Macrolide (+)‐Aspicilin Using Photolactonization as a Key Reaction (+)‐ Aspicilin , obtained from a lichen source of the Black Forest , has been proven to have the absolute configuration depicted by formula la . It is easily built up from phenol ( 14a ), 1,9‐nonanediol ( 13a ), and (−)‐( S ‐) methyloxiarane ( 6 ) ( cf. Scheme 2 ). The latter building block provides the first stereogenic center C(17). The heterocycle is produced by photolactonization, fairly early during the course of the synthesis. The second stereogenic center is generated diastereoselectively at C(6) in compound 8 , conveniently available from photolactone 9a or 9b / 9c . Its absolute configuration depends on the kind of reducing agent and is controlled by long‐range conformational transmission of chiral information . To explore the cause of stereoselection, 2D‐NMR spectroscopy, X‐ray structural analysis, and/or computer‐aided conformational search followed by energy minimization have been used extensively, revealing the importance of the local conformation of the lactone moiety. Compound 8 , on treatment with Yamamoto 's reagent, affords pre‐target compound 7a almost exclusively. The latter compound, on pyridine‐accelerated dihydroxylation with OsO 4 , gives preferentially (+)‐Aspicilin.
An asynchronous load balancing scheme for multi-server systems (2016)

In this paper, load balancing is defined as the process of allocating workload to reduce the mean job waiting time. In a distributed multi-server system, load balancing is a challenging task if there is no central coordination or time-synchronization among users. In this paper, we present a queuing model for a distributed asynchronous multi-server system. To realize load balancing, we propose a distributed algorithm based on protocol sequences, which are deterministic binary sequences and preassigned to users. The goal of this paper is to find optimal sequence sets which minimize the maximum mean job waiting time for all possible relative time shifts among users. We extend previous results reported in the literature to show that Shift-Invariant (SI) protocol sequences can ensure that the mean job waiting time is invariant for different time shifts. Moreover, our numerical studies indicate that the load balancing scheme based on SI sequences outperform the random sequence scheme, the completely random scheme and the probabilistic scheme.
Risoluzione di una cisti liquorale in fossa cranica posteriore dopo unishunt cisto-peritoneale (1992)

Un neonato, che l'ecografia fetale aveva già indicato affetto da idrocefalo, e stato studiato dopo la nascita mediante ultrasonografia transfontanellare che ha rilevato una cisti liquorale in fossa cranica posteriore, non comunicante col IV ventricolo, ed un idrocefalo triventricolare. Le ecografie successive dimostravano un progressivo aumento delle dimensioni dei ventricoli e della cisti. La TC cerebrale confermava la grossa cisti sottotentoriale che comprimeva posteriormente il cervelletto ipoplasico. Il piccolo è stato operato mediante unishunt cisto-peritoneale. I controlli ecografici seriati hanno mostrato una sorprendemente rapida riduzione delle dimensioni della cisti e dei ventricoli cerebrali, fino a completa remissione del quadro patologico. Questo lavoro vuole sottolineare come l'ecografia cerebrale sia del tutto affidabile per la diagnosi delle cisti liquorali in FCP e rappresenti il metodo ideale per seguire l'evoluzione delle cisti e dell'eventuale idrocefalo prima e dopo il trattamento chirurgico.
On the Stability of DNA Origami Nanostructures in Low‐Magnesium Buffers (2018)

Abstract DNA origami structures have great potential as functional platforms in various biomedical applications. Many applications, however, are incompatible with the high Mg 2+ concentrations commonly believed to be a prerequisite for maintaining DNA origami integrity. Herein, we investigate DNA origami stability in low‐Mg 2+ buffers. DNA origami stability is found to crucially depend on the availability of residual Mg 2+ ions for screening electrostatic repulsion. The presence of EDTA and phosphate ions may thus facilitate DNA origami denaturation by displacing Mg 2+ ions from the DNA backbone and reducing the strength of the Mg 2+ –DNA interaction, respectively. Most remarkably, these buffer dependencies are affected by DNA origami superstructure. However, by rationally selecting buffer components and considering superstructure‐dependent effects, the structural integrity of a given DNA origami nanostructure can be maintained in conventional buffers even at Mg 2+ concentrations in the low‐micromolar range.
Low voltage blue-phase liquid crystal displays (2009)

A protrusion electrode structure is proposed to dramatically lower the operation voltage of the emerging blue-phase liquid crystal displays (BP-LCDs). Simulation results indicate that the generated horizontal electric field is not only strong but also penetrates deeply into the bulk LC layer. As a result, a low voltage (∼10 Vrms) and reasonably high transmittance (∼70%) BP-LCD can be achieved. This approach enables the BP-LCDs to be addressed by amorphous silicon thin-film transistors (TFTs). Widespread application of TFT BP-LCDs is foreseeable.
Analysis of Tissue Plasminogen Activator Eligibility by Sex in the Greater Cincinnati/Northern Kentucky Stroke Study (2015)

Within a large, biracial population, eligibility for r-tPA was similar by sex. Women were more likely to have the modifiable exclusion criterion of severe hypertension but were not more likely to be treated. Women were more likely to have 2 of the 5 ECASS III exclusion criteria. Undertreatment of hypertension in women is a potentially modifiable contributor to reported differences in r-tPA administration.
Keeping the beat: A large sample study of bouncing and clapping to music (2020)

The vast majority of humans move in time with a musical beat. This behaviour has been mostly studied through finger-tapping synchronization. Here, we evaluate naturalistic synchronization responses to music – bouncing and clapping - in 100 university students. Their ability to match the period of their bounces and claps to those of a metronome and musical clips varying in beat saliency was assessed. In general, clapping was better synchronized with the beat than bouncing, suggesting that the choice of a specific movement type is an important factor to consider in the study of sensorimotor synchronization processes. Performance improved as a function of beat saliency, indicating that beat abstraction plays a significant role in synchronization. Fourteen percent of the population exhibited marked difficulties with matching the beat. Yet, at a group level, poor synchronizers showed similar sensitivity to movement type and beat saliency as normal synchronizers. These results suggest the presence of quantitative rather than qualitative variations when losing the beat.