gebhart/patrepeval huggingface dataset:
Building Blocks for a Millimeter-Wave Multiport Multicast Chip-to-Chip Interconnect Based on Dielectric Waveguides (2018)

A multichip multiport communication network technology is proposed based on a network of dielectric waveguides. For optimum performance and best versatility, a combination of high-permittivity dielectric slab waveguide and low-permittivity flexible dielectric rod waveguide is proposed. Additional building blocks are a dielectric waveguide Y junction and transitions between waveguide types as well as between chip and waveguide. The resulting multichip multicast multiport interconnect network features low overall transmission loss and small chip-area consumption for the chip-to-waveguide transitions. Measurement results for all components are presented for frequency bands around 60 GHz and around 100 GHz. The insertion loss of the transition from on-chip microstrip line to dielectric slab waveguide, extracted from end-to-end measurements, is 3.3 dB around 60 GHz and 2.2 dB around 100 GHz. Experimental four-terminal networks, each comprising four chip-to-waveguide transitions and two dielectric waveguide Y junctions, show measured end-to-end insertion loss (including pass through two Y junctions and two chip-to-waveguide transitions) of 21 dB (around 60 GHz, covering 26-mm distance) and of 17 dB (around 100 GHz, covering 20-mm distance), respectively. These values outperform wireless interconnects by far and emphasize the performance and versatility of the proposed approach for chip-to-chip multicast multiport interconnects.
Managing User Preferences for Personalization in a Pervasive Service Environment (2007)

The importance of personalization in many application areas is now well accepted and this is true of both telecommunications and web services. One important research area which spans telecommunications and web services is that of pervasive systems. Here the role of personalization is essential in order for a pervasive system to function effectively without the need for unnecessary interaction with the user and for improving the user experience by providing appropriate support for the actions taken by the user. However, in order to provide personalization in such a system the system needs to build up an adequate set of user preferences. This is a non-trivial task. This paper describes briefly the approaches to personalization included in the development of the pervasive system in the Daidalos project. It discusses some of the strategies involved in managing user preferences and the approaches being taken in the Daidalos system. In particular in the second phase a novel approach is proposed to deal with this problem.
Tannic Acid Inhibits Proliferation, Migration, Invasion of Prostate Cancer and Modulates Drug Metabolizing and Antioxidant Enzymes (2016)

The aim of this study was to investigate the effects of plant phenolic compound tannic acid (TA) on proliferative, metastatic, invasive properties of prostate cancer (PCa) cells; PC-3 and LNCaP, as well as drug metabolizing and antioxidant enzymes. Characterization of TA was done by using FT-IR and NMR. TA dose dependently inhibited the proliferation of PC-3 and LNCaP cells with IC50 values 35.3 μM and 29.1 μM, respectively. Wound healing assay showed that TA significantly inhibited (92.7%) migration of PCa cells (p<0.0001). In addition, TA was found to have anti-invasive potential on PC-3 cells and it inhibited (80.9%, p<0.0001) invasion of PC-3 cells into matrigel. Only 17.8% of PC-3 cells can form colony in the 0.7% agarose after treatment of cells with TA at the IC50 value concentration. Furthermore, flow cytometry analyses with Annexin V-APC and 7-AAD staining demonstrated that TA increases early apoptosis rate of PC-3 cells by 25.8% and LNCaP cells by 20.9%. Besides, Western blot and qRT-PCR analyses also demonstrated that TA regulates protein and mRNA expressions of CYP17A1, CYP3A4, CYP2B6, NQO1, GSTM1 and GSTP1 enzymes. The results obtained from this study show that TA might be a good candidate for combinational therapy and highly effective strategic molecule for reducing the occurrence of PCa.
The Analysis of Dual-Junction Tandem Solar Cells Enhanced by Surface Dispensed Quantum Dots (2018)

The luminescent down-shifting (LDS) effect of a colloidal quantum dot layer on a dual junction solar cell is explored and analyzed. A 5.47% enhancement of power conversion efficiency is recorded when green quantum dots are dispersed on device surface. The surface reflectance spectra before and after the quantum dot dispenses are necessary to decouple the different mechanisms between antireflective and LDS effects. A further deduction of formulation on the dual-junction device with antireflection and LDS effect is presented and as high as 44.6% of short-circuit current increase in the green quantum dot case can be attributed to the LDS effect according to our calculation.
Autonomous target localization using quadrotor (2014)

In this paper, autonomous target localization is achieved on quadrotor helicopter, with the use of 2D laser rangefinder and fixed monocular camera. Color-featured target is located in 3D space without prior knowledge of its size or shape. Coordinate systems of camera and laser rangefinder are integrated to establish body-fixed reference coordinate system for both localization and flight control. Rotation compensation algorithm is developed to neutralize the errors introduced by the changes of attitude angles during the flight. With this feature, quadrotor can obtain the real world coordinates of target from one single frame of camera once the target is captured and identified, without the requirement of keeping orientated towards the target all the time. The relative position between quadrotor and target is updated every time the target is located. Indoor experiments are conducted with Asctec Pelican quadrotor to demonstrate the performance of the proposed localization approach.
Differences in the scaling of area and mass of Ginkgo biloba (Ginkgoaceae) leaves and their relevance to the study of specific leaf area (2011)

These results indicate that the protocols used to sample leaves for the analysis of foliar functional traits such as specific leaf area need to acknowledge and cope with the effects of leaf and shoot polymorphisms on the quantification of functional traits (and on the construction and testing of hypotheses about these traits).
[Generation of Ayu17-449 gene knockout mice by gene trapping]. (2006)

We report the generation of Ayu17-449 gene knockout mice in an effort to facilitate studies of its function during mouse development, A special gene trapping vector was transfected into mouse ES cells. The clone with the trapped gene trap was identified by 5' RACE and Southern blot analysis. Ayu17-449 trapped mice were then generated by using this ES clone. In addition, the expression of Ayu17-449 in this mutant line was analyzed with Northern blot. Results showed that in these mutant mice, the trapping vector was located upstream of the Ayu17-449 initiation site, and as a result, the transcription of Ayu17-449 gene was inhibited. Ayu17-449 trapped mice are a useful tool for the analysis of Ayu17-449 gene function in mouse development.
A 65 nm 2-Billion Transistor Quad-Core Itanium Processor (2009)

This paper describes an Itanium processor implemented in 65 nm process with 8 layers of Cu interconnect. The 21.5 mm by 32.5 mm die has 2.05B transistors. The processor has four dual-threaded cores, 30 MB of cache, and a system interface that operates at 2.4 GHz at 105degC . High speed serial interconnects allow for peak processor-to-processor bandwidth of 96 GB/s and peak memory bandwidth of 34 GB/s.
Tamoxifen in patients with advanced pancreatic adenocarcinoma (1996)

Estrogen and somatostatin receptors have been found in pancreatic carcinoma cells, The growth of pancreatic carcinomas has been shown to be inhibited by various endocrine treatments. In view of these findings, a well known anti-estrogen tamoxifen has been used, both as a single agent and in combination with other agents, in clinical trials in patients with unresectable carcinoma of the exocrine pancreas. The impact on survival of tamoxifen in patients with advanced pancreatic adenocarcinoma has been assessed among patients from the previously reported trials of tamoxifen as a single agent, and compared with the survival of patients treated with the synergistic combination of intravenous Onconase plus oral tamoxifen. While a few patients treated with tamoxifen as a single agent may survive for prolonged period of time, the significance of such results remains uncertain in view of the lack of significant survival difference between patients treated with tamoxifen vs. untreated controls in prospectively randomized trials, and vis a vis clearly multifactorial determination of survival. On the other hand, the synergistic combinations of agents that demonstrate favorable toxicity profiles may offer significant survival advantage, at least in some patients with advanced pancreatic cancer.
Effects of Metal Coordination Geometry on Stabilization of Human Telomeric Quadruplex DNA by Square-Planar and Square-Pyramidal Metal Complexes (2008)

A series of square-planar and square-based pyramidal metal complexes (metal = Ni(2+), Cu(2+), Zn(2+), and V(4+)) with salphen and salen derivatives as ligands have been prepared. The X-ray crystal structures of three of these complexes are reported, giving insight into the geometric properties of the compounds. The interactions of these complexes with duplex and human telomeric quadruplex DNA have been studied by fluorescence resonance energy transfer (FRET), fluorescent intercalator displacement assay, and in one case circular dichroism. These studies have shown the square-planar metal complexes to be excellent quadruplex DNA stabilizers. In addition, FRET competition assays have shown the complexes to have a high degree of selectivity for the DNA quadruplex versus duplex DNA. These studies have allowed us to establish the most important features that metal complexes should have to interact selectively with quadruplex DNA. This will be of value in defining the best strategy to prepare metal complexes as potential anticancer drugs.
Intracellular Protein Delivery System Using a Target-Specific Repebody and Translocation Domain of Bacterial Exotoxin (2017)

With the high efficacy of protein-based therapeutics and plenty of intracellular drug targets, cytosolic protein delivery in a cell-specific manner has attracted considerable attention in the field of precision medicine. Herein, we present an intracellular protein delivery system based on a target-specific repebody and the translocation domain of Pseudomonas aeruginosa exotoxin A. The delivery platform was constructed by genetically fusing an EGFR-specific repebody as a targeting moiety to the translocation domain, while a protein cargo was fused to the C-terminal end of the delivery platform. The delivery platform was revealed to efficiently translocate a protein cargo to the cytosol in a target-specific manner. We demonstrate the utility and potential of the delivery platform by showing a remarkable tumor regression with negligible toxicity in a xenograft mice model when gelonin was used as the cytotoxic protein cargo. The present platform can find wide applications to the cell-selective cytosolic delivery of diverse proteins in many areas.
Industrial Chemicals: Fermentation and Immobilized Cells (2020)

Versatility of performance and ease of handling have favoured the use of microorganisms for the production of industrial chemicals for a long time. This chapter presents an overview of the applications, actual and potential, of microorganisms for the production of a broad latitude of industrial chemicals. Microbial cells are used for the production of industrial chemicals because of the catalytic activities of the enzymes they contain. Microbial cells may be used for the synthesis of industrial chemicals in a number of ways including: fermentations with living cells; immobilized growing cells; immobilized living; and immobilized dead cells. The decision as to which approach, enzymatic, fermentation, or immobilized cells is most economical for production of a particular product is best carried out on a case-by-case basis. The microbial synthesis of indigo by Escherichia coli represents an exciting example of the application of recombinant DNA technology to the field of chemical synthesis.
Results of Two Open-Label, Multicenter Phase II Studies of Docetaxel, Platinum Salts, and Trastuzumab in HER2-Positive Advanced Breast Cancer (2004)

Combinations of docetaxel, a platinum salt, and trastuzumab are feasible and active in patients with advanced breast cancers that overexpress HER2. The BCIRG is conducting ongoing randomized studies of the three-drug combination in both the metastatic and adjuvant settings.
Determination of nitrated polycyclic aromatic hydrocarbons by fused silica capillary gas chromatography/negative ion chemical ionization mass spectrometry (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDetermination of nitrated polycyclic aromatic hydrocarbons by fused silica capillary gas chromatography/negative ion chemical ionization mass spectrometryThomas. Ramdahl and Kjell. UrdalCite this: Anal. Chem. 1982, 54, 13, 2256–2260Publication Date (Print):November 1, 1982Publication History Published online1 May 2002Published inissue 1 November 1982https://pubs.acs.org/doi/10.1021/ac00250a027https://doi.org/10.1021/ac00250a027research-articleACS PublicationsRequest reuse permissionsArticle Views218Altmetric-Citations71LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
USH2A gene mutations in rabbits lead to progressive retinal degeneration and hearing loss (2022)

Abstract Mutations in USH2A gene are responsible for the greatest proportion of hearing and vision loss among individuals with Usher Syndrome (USH) and for autosomal recessive non-syndromic retinitis pigmentosa. Mutations on USH2A exon 13 account for more than 35% of the disease causing USH2A variants including the most prevalence point mutation, c.2299delG, a frameshift mutation. The lack of a clinically relevant animal model has been a bottleneck for the development of therapeutics for USH2A related vision loss. Using CRSPR/Cas9 technology, this study establishes a rabbit line carrying an USH2A frameshift mutation on exon12 (equivalent to human USH2A Exon 13) as a novel mammalian animal model of USH2A. The bi-allelic mutant rabbits exhibit hyper reflective signals in FAF indicating RPE damage and OCT changes indicating photoreceptor degeneration as early as 4 months of age. ERG signals of both rod and cone function were reduced in the USH2A mutant rabbits starting from 7 months old and further decreased at 15-22 months old, indicating progressive retinal photoreceptor degeneration, which is further confirmed by retinal histopathology examination. ABR examination showed moderate to server hearing loss in the USH2A mutant rabbits. These results indicated that disruption of USH2A gene in rabbits is sufficient to induce hearing loss and progressive photoreceptor degeneration. To our knowledge, this is the first mammalian animal model of USH2 which closely recapitulates the phenotype of retinitis pigmentosa in human patients. This study supports the use of rabbits as a clinically relevant animal model to understand the pathogenesis and to develop novel therapeutics for Usher Syndrome.
Effect of Gas Ambient on the Synthesis of Al and N Co‐doped ZnO: (Al,N) Films and their Influence on PEC Response for Photoelectrochemical Water Splitting Application (2011)

This chapter contains sections titled: Introduction Experimental Results and Discussion Conclusions Acknowledgements
Magnetic and electronic states of a monatomic Fe(001) layer facing an epitaxial MgO(001) tunnel barrier studied by using XAS and XMCD measurements (2005)

Epitaxial multilayers with structure of bcc-Co(001)(6 ML)/bcc-Fe(001)(1 or 2 ML)/MgO(001)(20 /spl Aring/) were prepared by using molecular beam epitaxy (MBE) with in-situ RHEED observation. Magnetic moments of the 1 and 2 ML-Fe layers evaluated using the sum rules from the energy integration of the XAS and XMCD spectra were found to be considerably higher than that of bulk Fe.
Association of cystathionine beta-synthase polymorphisms and aneurysmal subarachnoid hemorrhage (2017)

OBJECTIVE Cystathionine β-synthase (CBS) is involved in homocysteine and hydrogen sulfide (H<sub>2</sub>S) metabolism. Both products have been implicated in the pathophysiology of cerebrovascular diseases. The impact of CBS polymorphisms on aneurysmal subarachnoid hemorrhage (aSAH) and its clinical sequelae is poorly understood. METHODS Blood samples from all patients enrolled in the CARAS (Cerebral Aneurysm Renin Angiotensin System) study were used for genetic evaluation. The CARAS study prospectively enrolled aSAH patients at 2 academic institutions in the United States from 2012 to 2015. Common CBS polymorphisms were detected using 5'exonuclease genotyping assays. Analysis of associations between CBS polymorphisms and aSAH was performed. RESULTS Samples from 149 aSAH patients and 50 controls were available for analysis. In multivariate logistic regression analysis, the insertion allele of the 844ins68 CBS insertion polymorphism showed a dominant effect on aSAH. The GG genotype of the CBS G/A single nucleotide polymorphism (rs234706) was independently associated with unfavorable functional outcome (modified Rankin Scale Score 3-6) at discharge and last follow-up, but not clinical vasospasm or delayed cerebral ischemia (DCI). CONCLUSIONS The insertion allele of the 844ins68 CBS insertion polymorphism was independently associated with aSAH while the GG genotype of rs234706 was associated with an unfavorable outcome both at discharge and last follow-up. Increased CBS activity may exert its neuroprotective effects through alteration of H<sub>2</sub>S levels, and independent of clinical vasospasm and DCI.
Frequent Meiotic Recombination Between the Ends of Truncated Chromosome Fragments of Saccharomyces cerevisiae (1999)

A single truncated chromosome fragment (TCF) in diploid cells undergoes frequent ectopic recombination during meiosis between markers located near the ends of the fragment. Tetrads produced by diploids with a single TCF show frequent loss of one of the two markers. This marker loss could result either from recombination of the TCF with one of the two copies of the chromosome from which it was derived or from ectopic recombination between the ends of the TCF. The former would result in shortening of a normal chromosome and lethality in one of the four spores. The high frequency of marker loss in tetrads with four viable spores supports recombination between the TCF ends as the main source of marker loss. Most of the spore colonies that display TCF marker loss contained a TCF with the same marker on both ends. Deletion of most of the pBR322 sequences distal to the marker at one of the subtelomeric regions of the TCF did not reduce the overall frequency of recombination between the ends, but affected the loss of one marker significantly more than the other. We suggest that the mechanism by which the duplication of one end marker and loss of the other occurs is based on association and recombination between the ends of the TCF.
Centering the Patient in Postpartum Contraceptive Counseling (2022)

Birth control has long been considered an essential part of postpartum rounds. Many health care providers believe prevention of pregnancy is a priority in the postpartum period and that the inpatient postpartum stay is an ideal time to discuss contraception. This belief is not necessarily shared by birthing people. Many patients are unready to talk about contraception hours after birth, and contraceptive counseling may feel punitive for people whose reproduction has been marginalized. Health care providers must acknowledge this harmful and racist history to change counseling practices actively and thoughtfully to best meet patient needs while simultaneously respecting patient autonomy.
The International Consultation on Incontinence Modular Questionnaire: www.iciq.net (2006)

The ICIQ can offer a full range of urinary tract symptom questionnaires. The website will aim to attract collaborators committed to the concept of this internationally accepted modular questionnaire who are willing to help with its development.
OP02.04: Aortic coarctation: biventricular functional pattern in the third trimester of pregnancy (2017)

To describe the biventricular functional pattern in fetuses with aortic coarctation (AC). A comprehensive echocardiography was performed at third trimester of pregnancy in 21 fetuses with confirmed AC (2011-2016). Two gestational-age (GA) matched controls were selected for each case. GA, estimated fetal weight (EFW) and standard morphometric and Doppler parameters were obtained. Biventricular systolic and diastolic function was assessed by M-mode, pulse-wave and tissue Doppler imaging techniques, including: stroke volume (SV), cardiac output (CO), fractional area change (FAC), ejection (EF) and shortening fraction (SF), peak ventricular filling velocities and ratio (E/A ratio), mitral and tricuspid annular displacement (MAPSE and TAPSE) and peak annular velocities (S',E',A' and E/E' ratio). GA and EFW at echocardiography were similar between groups (31.6 vs. 31.7 weeks and 1946 vs. 1951g, respectively). Fetuses with AC showed a higher tricuspid to mitral ratio (1.51 vs. 1.03, p<0.001) with significant tricuspid regurgitation and reverse flow at the aortic isthmus in 27% and 25% of cases, respectively. While the left ventricular (LV) function was mainly preserved, the right ventricular (RV) CO was elevated compared to controls (416 vs. 253 ml/min/kg; p=0.005), which was associated with an increased longitudinal function: higher E' (9.21 vs. 7.69 cm/s, p=0.006) and S' velocities (8.02 vs. 7.37 cm/s, p=0.037), impaired global systolic function: decreased FAC (25 vs. 32%,p=0.037), EF (48 vs. 56%, p=0.043) and SF (26 vs. 32%,p<0.027) and signs of diastolic dysfunction: decreased E/A (0.69 vs. 0.77, p=0.007) and E/E' ratios (5.1 vs. 5.9, p=0.042). In the third trimester of pregnancy, fetuses with AC present RV dominance associated with increased RV CO and longitudinal function, impaired global systolic function and signs of diastolic dysfunction. On the contrary, LV function is essentially preserved.
A Polymer Waveguide Material Optimized for On-Board Optical Links and Si Photonic Interfaces (2017)

We report on a polymer optical waveguide material with 0.29 dB/cm loss at 1550nm, wide spectral window of transparency, environmental stability, and solder-reflow compatibility. Flexible ribbons are sufficiently robust for standard high-throughput microelectronics assembly.
Geographic variation in the yellow mud turtle, Kinosternon flavescens, from the central and southwestern United States, and northwestern Mexico (1980)

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