gebhart/patrepeval huggingface dataset:
Indonesian Medicinal Plants. VIII. Chemical Structures of Three New Triterpenoids, Bruceajavanin A, Dihydrobruceajavanin A, and Bruceajavanin B, and a New Alkaloidal Glycoside, Bruceacanthinoside, from the Stems of Brucea javanica (Simaroubaceae). (1994)

Three new apotirucallane-type triterpenoids named bruceajavanin A (1) dihydrobruceajavanin A (2) and bruceajavanin B (3), and a novel beta-carboline alkaloidal glycoside named bruceacanthinoside (4) were isolated from the stems of Brucea javanica (Simaroubaceae), a traditional medicine used to treat malaria in the Bengkulu area, Sumatra, Indonesia. Their chemical structures have been elucidated on the bases of their chemical and physicochemical properties. Bruceajavanin A (1), dihydrobruceajavanin A (2) and bruceacanthinoside (4) were shown to inhibit growth of the cultured malarial parasite Plasmodium falciparum K1 of a chloroquine-resistant strain.
Atmospheric pressure chemical ionization mass spectrometry of aldehydes in biological matrices (2004)

Application of high-performance liquid chromatography (HPLC) and tandem mass spectrometry (MS/MS) for detection of aldehydes in biological samples such as blood, yoghurt, and milk, is reported. Sample preparation is easy, and the presented method is both sensitive and selective. It is based on the widely used dinitrophenylhydrazine derivatization, followed by extraction with n-hexane and a simple reversed-phase HPLC separation. Detection is performed by atmospheric pressure chemical ionization (APCI) in negative ion mode, with detection limits in the low picogram range. Using MS/MS, acetone and propionaldehyde can clearly be distinguished, facilitating propionaldehyde quantitation even in the presence of high acetone levels. Quantitation by direct MS/MS is also feasible, well suited for high-throughput applications, although not as accurate as using HPLC/MS/MS.
A fast full search block matching algorithm for MPEG-4 video (2003)

In MPEG-4, motion vectors on both 16/spl times/16 macroblocks and 8/spl times/8 blocks could be used. We propose a block matching algorithm which can find both of them with small computational complexity. It is shown that the number of operations for motion estimation (ME) can be reduced by an expanded successive elimination algorithm (SEA) while maintaining the same accuracy of the full search ME algorithm. In the SEA, the efficiency of reducing the number of ME operations mostly depends upon the appropriate selection of an initial motion vector for searching. We first propose the method of the initial motion vector selection for SEA. We then expand the traditional SEA for the MPEG-1 or MPEG-2 for MPEG-4 in which both 16/spl times/16 macroblocks and 8/spl times/8 blocks are used. In consequence of our simulation, the significance of the proposed method is verified.
The role of amino acids in the regulation of protein synthesis in perfused rat liver. II. Effects of amino acid deficiency on peptide chain initiation, polysomal aggregation, and distribution of albumin mRNA. (1982)

Decreased rates of protein synthesis which occurred in rat livers perfused with amino acid-deficient medium were accompanied by a loss of polysomes and a doubling of concentrations of ribosomal subunits and monomers as compared to unperfused liver or livers perfused with amino acid-supplemented medium. The loss of polysomes was not the result of mRNA degradation because this effect could be reversed by addition of amino acids to the perfusion medium. Instead, loss of polysomes indicated an impairment in peptide chain initiation. To determine whether the block of initiation could be the result of sequestration of mRNA in untranslatable pools, the content of albumin mRNA in membrane-bound and free polysomes and in the non-polysomal fraction isolated on sucrose density gradients was determined by hybridization to an albumin cDNA. In livers perfused with an amino acid-supplemented medium, 90% of the albumin mRNA was found in bound polysomes, and with amino acid-deficient medium, this value was decreased to 80%. Thus, there was no indication of a significant pool of mRNA which was not being translated. The block of initiation was, however, accompanied by a marked change in density and methionine-binding characteristics of the 40 S ribosomal subunit in livers perfused with deficient medium as compared to livers perfused with supplemented medium or to unperfused livers. There was a relative loss of 40 S subunits in a low density form, 1.41 g/cm3, an increase in the proportion in a high density form, 1.48 g/cm3, and a decrease in binding of [35S]methionine to 40 S ribosomal subunits. These changes provide evidence of reduced rates of formation of the 40 S initiation complex.
Dissecção espontânea isolada da artéria mesentérica superior: qual a melhor abordagem terapêutica? (2013)

Universidade Estadual Paulista Faculdade de Medicina de Botucatu Departamento de Cirurgia e Ortopedia
Spider dragline silk as torsional actuator driven by humidity (2019)

Self-powered actuation driven by ambient humidity is of practical interest for applications such as hygroscopic artificial muscles. We demonstrate that spider dragline silk exhibits a humidity-induced torsional deformation of more than 300°/mm. When the relative humidity reaches a threshold of about 70%, the dragline silk starts to generate a large twist deformation independent of spider species. The torsional actuation can be precisely controlled by regulating the relative humidity. The behavior of humidity-induced twist is related to the supercontraction behavior of spider dragline silk. Specifically, molecular simulations of MaSp1 and MaSp2 proteins in dragline silk reveal that the unique torsional property originates from the presence of proline in MaSp2. The large proline rings also contribute to steric exclusion and disruption of hydrogen bonding in the molecule. This property of dragline silk and its structural origin can inspire novel design of torsional actuators or artificial muscles and enable the development of designer biomaterials.
Plasma Taurine, Diabetes Genetic Predisposition, and Changes of Insulin Sensitivity in Response to Weight-Loss Diets (2016)

Our data suggest that blood taurine levels might differentially modulate the effects of diabetes-related genes on improvement of insulin sensitivity among overweight/obese patients on weight-loss diets.
Commentary on: The Layered Anatomy of the Nose: An Ultrasound-Based Investigation (2021)

See the Original Article here. Nonsurgical rhinoplasty has become common practice for many plastic surgeons and related specialists, with increasing numbers of patients undergoing this procedure each year.1 Despite often being promoted as a “noninvasive” alternative to surgical rhinoplasty, filler treatment of the nose is not without risk. The most serious complication that can occur is loss of vision, which is believed to result from an inadvertent intravascular injection around the nose. Given this rare, but catastrophic, outcome, our specialty must continue to emphasize safety protocols and identify potential ways to minimize this occurrence. This article, titled “The Layered Anatomy of the Nose: An Ultrasound-Based Investigation,” 2 makes one such valuable contribution to our literature. By means of ultrasound analysis, the authors offer a unique description of layered soft tissue anatomy in the nose and its clinical relevance to injection safety for nasal filler. A total of 60...
Using PyPSA-Earth to Address Energy Systems Modelling Gaps in Developing Countries. a Case Study for Bolivia (2023)

Bolivia is a developing country in South America which is slowly starting its energy transition towards more renewable technologies. However, at this moment, Institutions in charge of regulating, operating, and planning the development of the sector are still working with "black box" (or licensed) models, which are costly and less transparent, and are highly dependent on external expertise to formulate national plans. A proper transition will arguably require endogenous know-how and resources to be sustainable, affordable, and sovereign for the country. In this context, open-source energy models are increasingly used in Bolivia, mostly by academic and non-profit institutions. These are used to study alternative development scenarios, quantify environmental impacts and/or define potential techno-economic requirements. Previous works have focused on the development of dispatch models that analyse the stability and operation over short-terms and on energy-balance models to study impacts over long-term scenarios. However, while operation and planning aspects are somewhat covered independently, the combination of both is still missing (i.e. high time and spatial resolution and long-term horizon perspectives). To bridge this gap the PyPSA-Earth model was identified and used to derive a model specific for the Bolivian context using a dedicated workflow. The model is adapted to run and provide country-specific outputs regarding generation capacities, grid expansion and sector-specific demands, which are later compared with historical information to assess its accuracy and capabilities. Modelling results provide inputs regarding the characteristics of the tool and quantify deviations of its outputs compared to the Bolivian system in 2020. Based on these, it is concluded that the flexibility of the model, combined with its transparent structure, show great potential for implementation.
Questioning the Question -- Addressing the Answerability of Questions in Community Question-Answering (2014)

In this paper, we investigate question quality among questions posted in Yahoo! Answers to assess what factors contribute to the goodness of a question and determine if we can flag poor quality questions. Using human assessments of whether a question is good or bad and extracted textual features from the questions, we built an SVM classifier that performed with relatively good classification accuracy for both good and bad questions. We then enhanced the performance of this classifier by using additional human assessments of question type as well as additional question features to first separate questions by type and then classify them. This two-step classifier improved the performance of the original classifier in identifying Type II errors and suggests that our model presents a novel approach for identifying bad questions with implications for query revision and routing.
Hematopoietic stem cell therapy of autoimmune diseases (1998)

Hematopoietic stem cell transplantation is a new therapy for severe autoimmune diseases. Patients who have failed standard therapies and are at high risk of subsequent morbidity and mortality are being considered as candidates. Early results are encouraging. However, the number of patients treated is limited, only short-term follow-up is available, the mechanism of improvement or stabilization is unknown, and the procedure has the potential for life-threatening toxicity.
Extraretinal neovascularization induced by hypoxic episodes in the neonatal rat. (1994)

To test the hypothesis that hypoxia induces retinal neovascularization.To produce relative hypoxia in the avascular retina, newborn rats were exposed for 11 days to 80% oxygen interrupted daily by short episodes in room air. Episodes in room air lasted 1/2 hour or 1 hour followed by abrupt reintroduction, or 1/2 hour followed by progressive reintroduction to 80% oxygen lasting 3 hours to prolong the period of hypoxia. At the end of the 11 days of interrupted oxygen exposure, the animals were left in room air for 6 days.The incidence of neovascularization exhibited a dose-response relationship to the period out of 80% oxygen. Periods of approximately 3 hours produced neovascularization (in at least one eye) in 94% of the animals. The total area of the peripheral avascular retina was larger in animals exposed to prolonged periods of hypoxia than in those exposed for shorter periods. The incidence of neovascularization was strongly associated with the total area of the peripheral avascular retina and occurred in the inferior quadrant in 78% of the cases. Additional features of stage 3 retinopathy of prematurity (ROP), including arteriovenous shunts and ridges, were observed in some retinas.These data demonstrate that hypoxic episodes can induce extraretinal neovascularization in the rat and suggest that brief periods of oxygen deficiency could exacerbate progression of ROP. With the high incidence and predictability of localization of neovascularization, this model could be useful for the study of angiogenesis and for evaluation of antiangiogenic or antioxidant substances.
Keep Your Friends Close, but Your Routeservers Closer: Insights into RPKI Validation in the Internet (2023)

IP prefix hijacks allow adversaries to redirect and intercept traffic, posing a threat to the stability and security of the Internet. To prevent prefix hijacks, networks should deploy RPKI and filter bogus BGP announcements with invalid routes. In this work we evaluate the impact of RPKI deployments on the security and resilience of the Internet. We aim to understand which networks filter invalid routes and how effective that filtering is in blocking prefix hijacks. We extend previous data acquisition and analysis methodologies to obtain more accurate identification of networks that filter invalid routes with RPKI. We find that more than 27% of networks enforce RPKI filtering and show for the first time that deployments follow the business incentives of inter-domain routing: providers have an increased motivation to filter in order to avoid losing customers' traffic. Analyzing the effectiveness of RPKI, we find that the current trend to deploy RPKI on routeservers of Internet Exchange Points (IXPs) only provides a localized protection against hijacks but has negligible impact on preventing their spread globally. In contrast, we show that RPKI filtering in Tier-1 providers greatly benefits the security of the Internet as it limits the spread of hijacks to a localized scope. Based on our observations, we provide recommendations on the future roadmap of RPKI deployment. We make our datasets available for public use [https://sit4.me/rpki].
Microsoft Windows 7 Unleashed (2009)

Covers Release Candidate of Windows 7. With purchase of this book you will get a free online edition written on final product. See product registration ad in back of book for details. Microsoft Windows 7 Unleashed gives IT professionals, serious power users, and true geeks the powerhouse Windows 7 tweaks, hacks, techniques, and insights they need: knowledge that simply cant be found anywhere else. Top Windows expert Paul McFedries dives deep into Windows 7, returning with the most powerful ways to handle everything from networking to administration, security to scripting. McFedries begins with advanced customization, covering everything from startup/shutdown to the file system. He introduces new ways to tune Windows 7 performance, police Windows via Group Policies, tweak the Registry, make the most of Windows 7s management tools, and control Windows 7 from the command line. Youll find thorough coverage of securing Windows 7, including detailed guidance on web and email security and hardening both wireless and wired networks. Youll also discover better ways to troubleshoot devices, networks, and startup; add Macs to Windows networks; and automate Windows administration with state-of-the-art scripting techniques. This book is packed with expert tips, tricks, and troubleshooting techniques drawn from McFedries unsurpassed Windows experience. If you want maximum value and performance from your Windows 7 PCs, you wont find a more valuable resource. Customize everything about Windows 7: IE8, startup/shutdown, file systems, the Start menu, Taskbar, and more Systematically monitor, tune, and optimize Windows performanceincluding practical techniques for accelerating startup Set up an easy, automated 9-Step maintenance schedule for any Windows 7 PC Unleash Windows 7s power user tools, including Group Policies, the Registry, MMC, and the command line Secure Windows 7 with security settings: auto-lock, Windows Firewall, Windows Defender, parental controls, BitLocker encryption, and more Protect your web privacy with Windows 7s new InPrivate Browsing Solve problems with Windows 7, startup, networking, and hardware Set up reliable Windows 7 networks, and manage them efficiently Safely provide remote access and VPN connectivity Use Windows 7 as a Web server Program the Windows Scripting Host and Windows PowerShell ON THE WEB: Free Online Edition! When Microsoft releases the final product, you can get an updated edition of this book absolutely free! All examples and source code presented in this book $49.99 USA / $59.99 CANz
Paris (2011)

‘I cannot bear to think of your being alone in Paris, the very words give me a chill. English speaking countries seem so different from foreign. I do not admire the French nation, and have less confidence in individuals of that race than in English’ (L1, 12). Those are T. S. Eliot's mother's words in April 1910, after her son had told her he would spend a year in Paris following his graduation from Harvard. Although her reluctance was plain to read, he went nonetheless. In every respect, it was a decisive year. When Eliot departed for Paris, he felt a real temptation to become a French poet. When he returned to America a year later, he had decided against this move. What had happened? Eliot's mother provides a clue, for Eliot was ‘alone in Paris’ for two reasons. First, as his mother makes quite clear, he had broken with his American cultural background. Second, it was not easy to create new ties in his host country. In a letter of 1914 to his friend Conrad Aiken, Eliot admitted that his stay in Paris occasioned ‘one of those nervous sexual attacks which I suffer from when alone in a city’ (L1, 82). It was no accident that the poems contained in his first collection, Prufrock and Other Observations (1917), examine the theme of urban dereliction after the manner of two French poets, Baudelaire and Laforgue.
Effect of moxibustion on aged rats. (Report 1). Recovering the regular cyclicity by periodic moxibustion. (1987)

生殖腺, 内分泌系における加齢現象の機序と灸刺激の効果について検索した。Wistar系成熟雌性ラットの卵巣を摘除すると同時にこれを皮下に移植することにより, 人為的に乱した発情周期を正常化させる条件について観察し, 性周期のリズムに対する灸の作用について検討を加えた。去勢移植の当日より4日ごとに10回, 艾量5mgを百会, 左右京門穴相当部位に等分に施灸。40日間の施灸期間および終了後さらに40日間, 周期性誘発の成否を膣上皮細胞像から観察した。結果は施灸により, プロゲステロン2mg投与で誘発し得た周期性 (4日周期で, 投与日と相関を示すリズム) に集束する傾向を示した。中枢抑制物質レセルピン投与では周期性の乱れが大きく, 自律周期の回復も遅れた。
Airborne observations of methane emissions from rice cultivation in the Sacramento Valley of California (2012)

Airborne measurements of methane (CH 4 ) and carbon dioxide (CO 2 ) were taken over the rice growing region of California's Sacramento Valley in the late spring of 2010 and 2011. From these and ancillary measurements, we show that CH 4 mixing ratios were higher in the planetary boundary layer above the Sacramento Valley during the rice growing season than they were before it, which we attribute to emissions from rice paddies. We derive daytime emission fluxes of CH 4 between 0.6 and 2.0% of the CO 2 taken up by photosynthesis on a per carbon, or mole to mole, basis. We also use a mixing model to determine an average CH 4 /CO 2 flux ratio of −0.6% for one day early in the growing season of 2010. We conclude the CH 4 /CO 2 flux ratio estimates from a single rice field in a previous study are representative of rice fields in the Sacramento Valley. If generally true, the California Air Resources Board (CARB) greenhouse gas inventory emission rate of 2.7 × 10 10 g CH 4 /yr is approximately three times lower than the range of probable CH 4 emissions (7.8–9.3 × 10 10 g CH 4 /yr) from rice cultivation derived in this study. We attribute this difference to decreased burning of the residual rice crop since 1991, which leads to an increase in CH 4 emissions from rice paddies in succeeding years, but which is not accounted for in the CARB inventory.
A continuous-time ΣΔ modulator with 88dB dynamic range and 1.1MHz signal bandwidth (2003)

A baseband continuous-time multi-bit /spl Sigma//spl Delta/ modulator achieves 88dB dynamic range over a 1.1MHz signal bandwidth consuming 62mW from a 3.3V supply. Excess loop delay encountered in conventional continuous-time modulators is eliminated by the proposed architecture. Clock-jitter sensitivity is considerably reduced compared with prior designs.
A Memory-Efficient Hashing by Multi-Predicate Bloom Filters for Packet Classification (2008)

Hash tables (HTs) are poorly designed for multiple off-chip memory accesses during packet classification and critically affect throughput in high-speed routers. Therefore, an HT with fast on-chip memory and high-capacity off-chip memory for predictable lookup-throughput is desirable. Both a legacy HT (LHT) and a recently proposed fast HT (FHT) have the disadvantage of memory overhead due to pointers and duplicate items in linked lists. Also, memory usage for an FHT did not consider the bits in counters for fair comparison with an LHT. In this paper, we propose a novel hash architecture called a Multi-predicate Bloom-filtered HT (MBHT) using parallel Bloom filters and generating off-chip memory addresses in the base- 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sup> number system, xisin{1,2,hellip}, which removes the overhead of pointers. Using a larger base of number system, an MBHT reduces on-chip memory size by a factor of log <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> b <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> / log <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> b <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> where b <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> and b <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> are bases of number system (b <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> >b <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sub> ). Compared to an FHT, the MBHT is approximately x(log <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> n + 4)/(2 log <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> n) times more efficient for on-chip memory, where n is the number of keys. This results in a significant reduction in the number of off- chip memory accesses. A simulation with a dataset of packets from NLANR shows the on-chip memory reductions by 1.7 and 2 times over an LHT and an FHT are made. Besides, an MBHT of base-16 needs less off-chip memory accesses by 2117 in total URL queries of NLANR, compared to an FHT.