gebhart/patrepeval huggingface dataset:
ChemInform Abstract: Synthesis of Conformationally Constrained DTPA Analogues. Incorporation of the Ethylenediamine Units as Aminopyrrolidines. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
26.4: Assembly of Reflective PDLC Microdisplays (2001)

Abstract Different methods for the filling and the assembly of reflective PDLC (Polymer Dispersed Liquid Crystal) microdisplays with a 4 μm cell gap are evaluated. The filling of the vias in the microdisplay and the stability of the cell gap after the curing of the PDLC are important parameters for displays with a high brightness.
Concepts in use of high-dose methotrexate therapy (1996)

In cancer chemotherapy, routine monitoring of drug concentrations has been practical only for methotrexate (MTX). The primary setting for pharmacokinetic monitoring of MTX is its use in high doses (HDMTX) for adjuvant therapy of osteosarcoma, for single-agent treatment of intracranial lymphomas, and in combination therapy of childhood leukemia as well as adult and pediatric non-Hodgkin lymphomas. Typically, HDMTX is infused in doses of 3-15 g/m2 over a period of 6-24 h. Precautions must be taken to ensure a high urine flow and an alkaline urine pH, so as to prevent precipitation of MTX in urine. Patients with decreased renal function, advanced in age, and taking nonsteroidal anti-inflammatory drugs or nephrotoxic agents are at increased risk of developing renal dysfunction during MTX infusion, thus being placed at high risk for toxicity. At the end of HDMTX infusion, and periodically thereafter for 24-48 h, drug concentrations are measured to assure that the disappearance rate of MTX from plasma is occurring at a normal rate. Also, at the end of HDMTX infusion, the patient is given leucovorin (5-formyl-tetrahydrofolic acid; LV), which replenishes intracellular stores of reduced folate and attenuates the toxicity secondary to HDMTX. In the presence of inappropriately high concentrations of MTX, routine doses of LV will be ineffective; the dose of LV required must be increased in proportion to the MTX concentration it faces in plasma. In practice, routine monitoring of plasma MTX concentrations allows early detection of abnormal clearance, as well as institution of early and effective countermeasures, including the use of increased and prolonged LV rescue.
Abstract 1714: Transcriptional networks downstream of the AR identify clinically relevant prostate cancer targets (2010)

Abstract The AR signalling axis is central to Prostate Cancer (PrCa) biology, shown by its use in both screening (PSA) and treatment of the disease (androgen deprivation therapy). Identifying direct target genes of the AR will provide a better understanding the key signalling pathways controlled by the AR in PrCa and could lead to improved biomarkers and future therapeutic targets for the disease. To this end we have performed fine mapping of androgen responsive gene expression in prostate cancer cell lines using Illumina bead-arrays, coupled with AR chromatin-immunoprecipitation and Solexa sequencing technology (ChIP-seq). This approach generated over ten thousand candidate AR target genes. We have then undertaken large scale, cross-platform validation using BioTrove Realtime PCR panels which allow the measurement of &amp;gt;600 transcripts simultaneously. Using this combination of approaches we have identified and validated several hundred AR regulated genes. We found that metabolic enzymes and kinases were significantly enriched in the set of direct AR regulated genes. In nine independent clinical gene expression studies we found that the most consistently up-regulated AR target gene was a calcium regulated kinase. At the protein level this kinase showed increased expression in two independent patient cohorts. A small molecule inhibitor of this kinase reduced the growth of a panel of PrCa cell lines in vitro and tumour growth in xenograft models. Interestingly, we found that the levels of this AR regulated kinase were reduced in clinical PrCa following androgen deprivation therapy, but were raised in Castrate Resistant disease. Therefore, we have identified an AR regulate kinase which contributes to tumour growth and is a potential marker and therapeutic target in both hormone naïve and anti-androgen resistant disease. In summary, these data show that combining expression analysis, ChIP-seq and high through-put validation has identified a framework to understand the oncogenic functions of the AR in prostate cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1714.
Conformity and genetic relatedness estimation in crop species having a narrow genetic base: the case of cucumber (Cucumis sativus L.)* (2005)

A set of 155 SSR (107) and SCAR (48) markers were used to evaluate 53 cucumber ( Cucumis sativus L.) accessions of diverse origin to characterize genetic relationships and to define a standard marker array that was most effective in detecting genetic differences in this germplasm array. A multivariate marker‐based analysis of diverse germplasm using this standard marker array (17 SSR and 5 SCAR markers) was compared with results from a set of 70 previously reported RAPD markers, and then used to explore the potential value of these genetic markers for plant variety protection (PVP) and the establishment of essential derivation (ED) threshold values in this species using elite lines and hybrids and backcross progeny. Diversity analysis allowed identification of distinctly different lines that were used for the construction of three sets of backcross families (BC 1 ‐BC 3 ). While general genetic relationships among accessions were similar in SSR/SCAR analyses (r s = 0.65) using two genetic distance (GD) estimators, differences in accession relationships were detected between RAPD and SSR/SCAR marker evaluations regardless of the estimator used. The GDs among elite germplasm with known pedigrees were relatively small (0.06‐0.23 for any pairwise comparison). GD values decreased and degree of fixation (at three to seven loci depending on the mating) increased with increased backcrossing such that recurrent parent allelic fixation occurred in least one family of each of the BC 3 families. In many instances the degree of fixation of loci was not uniformly achieved in the BC 3 . Although the level of genetic polymorphisms will likely restrict the use of molecular markers for PVP and the establishment of ED values, the use of single nucleotide differences will likely provide opportunities to define specific functional distances that have potential for PVP in cucumber. Nevertheless, without an expanded, genetically robust standard marker array (e.g. 50 codominant markers), ED threshold values will be difficult to define in this species, and perhaps will require the appraisal of single nucleotide polymorphisms as discriminators of difference in this species.
Microwave-Assisted Conversion of Levulinic Acid to γ-Valerolactone Using Low-Loaded Supported Iron Oxide Nanoparticles on Porous Silicates (2015)

The microwave-assisted conversion of levulinic acid (LA) has been studied using low-loaded supported Fe-based catalysts on porous silicates. A very simple, productive, and highly reproducible continuous flow method has been used for the homogeneous deposition of metal oxide nanoparticles on the silicate supports. Formic acid was used as a hydrogen donating agent for the hydrogenation of LA to effectively replace high pressure H2 mostly reported for LA conversion. Moderate LA conversion was achieved in the case of non-noble metal-based iron oxide catalysts, with a significant potential for further improvements to compete with noble metal-based catalysts.
Can we understand population healthcare needs using electronic medical records? (2019)

Pre-existing EMR systems may not capture sufficient information for reliable determination of healthcare needs. Thus, we should consider integrating policy-relevant healthcare need variables into EMRs.
A Case of Gastrojejunostomy: We Thought It Would Be a Sprint but Ended up a Marathon (2017)

This is a 55 year-old Caucasian female with a history of stage IV gastric adenocarcinoma at pylorus causing gastric outlet obstruction. Her tumor is metastatic to liver, complicated by malignant ascites and peritoneal carcinomatosis. She initially underwent gastro-duodenal stent placement to relieve GOO. Subsequently she developed malignancy associated gastroparesis, and obstruction of her gastro-duodenal stent leading to aspiration pneumonia. Given her malignant ascites, peritoneal carcinomatosis a decision was made to avoid percutaneous jejunal access and we proceeded with endoscopic gastro-jejunostomy. Prior to procedure patient underwent a large volume paracentesis, followed by CT abdomen to rule out any small bowel obstruction. She underwent endotracheal intubation and the procedure was performed under MAC sedation. Initially a standard forward-viewing scope was advanced through the gastro-duodenal stent to the fourth portion of duodenum. A stiff long 0.035 guidewire was advanced toward the jejunum under fluoroscopic guidance. A 20 mm dilation balloon was inserted over the guidewire, and, under fluorocopic and endosonographic guidance, we placed the balloon in the proximal jejunum as close as possible from the tip of the echoendoscope located in the distal stomach. Given the presence of preexisting stent, this location was challenging. With a 19G Sharkcore biopsy EUS needle, we punctured the jejunal balloon crossing the gastric wall, creating a gastroenterostomy. The lumen apposing metal stent (LAMS) was deployed, both flares had a complete opening. An XP scope was inserted and advanced to 4th part of duodenum, to pull the guidewire, with the guidewire out of nose and both ends were secured. On endoscopy, it showed that jejunal flare of LAMS was buried into the edematous jejunal wall. Due to risk of migration secondary to ascites reaccumulation and functional failure of end in the edematous wall, we proceeded to place a covered SEMS on with the guidewire in place, 18 mm X 6 cm Taewoog, was successfully deployed thourgh the LAMS lumen. Due to positioning of guidewire, it was technically difficult to guide SEMS towards jeujunal side, as guidewire was coming out of stomach the natural tendency of the stent was to go in that direction. With repeated maneuverings we were able to position the stent appropriately. Both ends of SEMS were located in a good position finally. Final contrast injection showed stent patency without leak. Watch the video: https://goo.gl/Juc3Ay
Methods and techniques of radar recognition (1994)

General information on radar recognition methods of recognition with the aid of narrowband signals methods of recognition using multifrequency signals methods of recognition using broadband signals selection of information features and decision rules for radar recognition methods of recognition using active response and passive radar data fusion as one of the promising ways of solving radar target recognition problems methods and technique of radar recognition countermeasures including those developed by stealth program perspective methods of recognition and trends in their development.
Strangulated Small Bowel Obstruction After Renal Transplant With No History of Laparotomy: Case Report. (2014)

Strangulated small bowel obstruction is a complication after abdominal surgery, which is rare in renal transplant patients. A 61-year-old man with a strangulated small bowel obstruction underwent renal transplant surgery 7 years before the current admission. He was admitted to our hospital for abdominal pain, nausea, and abdominal distention. An abdominal computed tomography and an ultrasound examination showed intestinal expansion and fluid collection without ascites. His disease was diagnosed as a small bowel obstruction and conservative treatment was begun. However, because of increasing abdominal pain and the collection of ascites, he underwent an emergency laparotomy and was diagnosed as having a strangulated small bowel obstruction. A fibrous cord had formed between the peritoneum (beside the transplanted kidney) and the root of the sigmoid mesocolon, strangulating the looped ileum and causing bleeding necrosis and hemorrhagic ascites collection. The cord and the necrotic ileum were resected, followed by an end-to-end anastomosis. He was discharged 17 days after the surgery in good condition. This is the first reported case of a person having a strangulated small bowel obstruction by a fibrous cord, who did not have a history of laparotomy after renal transplant. A strangulated small bowel obstruction after a renal transplant in a patient with no history of a laparotomy is a rare, but possible postoperative complications should be considered when making a differential diagnosis.
USES OF EPIDEMIOLOGY (1958)

USES OF EPIDEMIOLOGY Affiliation E. Gurney Clark CopyRight https://doi.org/10.2105/AJPH.48.8.1097-a Published Online: August 29, 2011
The effects of cinnamon extract on 3T3‐L1 pre‐adipocyte differentiation and cell size. (2015)

Cinnamon has long been used as a supplement for decreasing blood glucose and lipid values. Type 2 diabetes and obesity are growing concerns of public health and a better understanding of anomalies within these metabolic conditions are essential. Literature largely supports correlations between glucose and lipid metabolism control but few distinct pathway mechanisms have been proven experimentally. We proses that treatment of 3T3-L1 pre-adipocytes with cinnamon extract alters both carbohydrate and lipid metabolism and that in doing so alter differentiation As well. We explored lipid droplet formation and quantitated lipid volume as a marker of adipogenesis using oil red O staining. Experiments were completed in both monolayer and three-dimensional agarose cell culture. Cultures were treated with a variety of concentrations of cinnamon extract and evaluated at various time points for growth, cell size, morphology and viability. Our results suggest that treatment with cinnamon extract in both monolayer and agarose culture promote adipogenesis from the fibroblast-like morphology to the round adipocyte like morphology. Likewise, we see significant lipid droplet formation in treated cells. The cells were treated only with cinnamon extract and media plus calf or fetal serum and no other components were added to enhance differentiation. Differentiation was initiated even in the absence of differentiating media. Additionally we observed a reduction in the cell size when treated with cinnamon extract at plating. Cells that were grown in a three-dimensional environment but not treated with cinnamon extract or differentiating media also appeared to initiate differentiation.
The proline-rich region of Vav binds to Grb2 and Grb3-3. (1995)

Vav has structural features found in signaling proteins and is expressed only in hematopoietic cells. The recent development of mice Vav -/- has confirmed a major role of Vav in early blood cell development. We previously showed that Vav constitutively interacts with glutathione-S-transferase-Grb2. Coimmunoprecipitation experiments supported the idea of a complex formed by Vav-Grb2 in vivo. This complex is of potential interest in signaling of hematopoietic cells. In this work we localize the domains of Vav and Grb2 involved in this interaction. By the use of an in vivo genetic approach (the double hybrid system) and through in vitro experiments (glutathione-S-transferase fusion proteins) we furnish evidence that the interaction between Vav and Grb2 involves the C-SH3 domain of Grb2 and the proline-rich region located in the N-SH3 of Vav. Furthermore this was confirmed by the use of both Vav and Sos derived proline-rich peptides which blocked the binding. In addition we show that Vav also interacts with Grb3-3, a naturally occurring Grb2 isoform wich lacks functional SH2 domain.
Poly(pyrrole-N-carbodithioate) electrode for electroanalysis (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPoly(pyrrole-N-carbodithioate) electrode for electroanalysisD. M. T. O'Riordan and G. G. WallaceCite this: Anal. Chem. 1986, 58, 1, 128–131Publication Date (Print):January 1, 1986Publication History Published online1 May 2002Published inissue 1 January 1986https://pubs.acs.org/doi/10.1021/ac00292a031https://doi.org/10.1021/ac00292a031research-articleACS PublicationsRequest reuse permissionsArticle Views202Altmetric-Citations66LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Display pixel caching (2011)

A variety of standard video modes that stretch or zoom lower resolution video content linearly to take full advantage of large screen sizes have been implemented in TV sets. When content and screen aspect ratios differ, format proportions may be compromised, video content may be clipped, or screen regions may remain unused. Newer techniques, such as video retargeting and video upsampling, rescale individual video frames and can potentially match them to the display resolution and aspect ratio. However, none of these methods can display simultaneously more than is contained in a single frame.
Optimization of adiabatic frequency conversion in an all-pass resonator (2022)

Adiabatic frequency conversion (AFC) is a promising alternative for shifting the frequency of optical signals. In this paper we present a comprehensive theoretical study of the energy efficiency of AFC in an all-pass resonator. Through the Cauchy-Schwarz inequality, we deduce the upper limit of the energy efficiency of the AFC process and analyze its dependence on the input pulse shape. For a fixed pulse shape, we discuss the dependence of the AFC efficiency on its relevant timescales. We show that maximum efficiency requires overcoupling of the resonator to a degree dependent on the input pulse duration. We compare and contrast the requirements for optimal AFC for pulsed and continuous-wave inputs.
[Study of serum kinetics of vancomycin during the "antibiotic-lock" technique]. (1992)

The serum kinetics of vancomycin was studied in two patients aged 3 and 15 years during antibiotic therapy for catheter related sepsis associated with Staphylococcus epidermidis. Vancomycin was administered, simultaneously, by parenteral conventional doses (30 mg/kg/day div q 8 h) and using the antibiotic-lock technique in the infected catheter at a high concentration (150 mg/ml) during one hour, 3 hours after each infusion. Pharmacokinetics data did not show any significant change in the serum kinetics of the antibiotic. The results suggest that delivering a high concentration of vancomycin in the infected catheter using the lock technique may be useful to sterilize infected catheter without toxic effect.
Synergism between the antiproliferative activities of arabinosyladenine and N6-benzyladenosine. (1977)

N6-Benzyladenosine is a competitive inhibitor of adenosine deaminase from L-1210 cells in axenic culture as well as a potent antiproliferative agent in vitro and in vivo. Potentiation of the growth inhibitory activity of 9-beta-D-arabinosyladenine (ara-A) was observed in the L-1210 system with maximum synergism with a mixture of 16 micron ara-A and 10 micron benzyladenosine. Kinetic studies with L-1210 cell lysates showed values for Km of 0.25 mM ara-A and Ki of 0.23 mM benzyladenosine. It is suggested that ara-A and benzyladenosine in suitable combination may be expected to demonstrate enhanced clinical chemotherapeutic effectiveness.
Comparison of different modulation formats for polarization mode dispersion compensators (2006)

We propose a polarization mode dispersion (PMD) compensation scheme for wavelength-division-multiplexing (WDM) system, in which two WDM channels share one PMD compensator at the receiver site. The effect of different modulation formats on multi-stage PMD compensators is studied and compared by numerical simulations in 40-Gb/s WDM optical fiber communication system. The degree of polarization (DOP) of single state of polarization (SOP) optical signal is used as the feedback signal in PMD compensators. The particle swarm optimization (PSO) algorithm is used as the searching algorithm in WDM systems. The compensated DOP values of return-to-zero (RZ) format and nonreturn-to-zero (NRZ) format by multi-stage PMD compensators have been increased distinctly compared to the corresponding cases without compensation. It is shown that the PSO algorithm is implemented successfully in adaptive multi-stage PMD compensation in a 40-Gb/s optical WDM system. The compensated eye diagrams for the two channels by multi-stage PMD compensators indicate that the three-stage PMD compensator which eliminates the influence of second-order PMD completely in WDM system takes the best efficiency in the multi-stage PMD compensators for RZ format and NRZ format.
Selectivity Enhancement of Gas Sensitive Field Effect Transistors by Dynamic Operation (2015)

The cover image shows the signal of a dynamically operated SiC-FET gas sensor when both, the operating temperature and the applied gate bias are modulated.
Mapping the Enantiomerization Routes of Triarylvinyl Propellers. Barriers to the Three-Ring Flip and the Three Different Two-Ring Flips of m-Methoxy-Substituted Trimesitylvinyl Isopropyl Ethers (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMapping the Enantiomerization Routes of Triarylvinyl Propellers. Barriers to the Three-Ring Flip and the Three Different Two-Ring Flips of m-Methoxy-Substituted Trimesitylvinyl Isopropyl EthersElimelech Rochlin and Zvi RappoportCite this: J. Org. Chem. 1994, 59, 14, 3857–3870Publication Date (Print):July 1, 1994Publication History Published online1 May 2002Published inissue 1 July 1994https://pubs.acs.org/doi/10.1021/jo00093a018https://doi.org/10.1021/jo00093a018research-articleACS PublicationsRequest reuse permissionsArticle Views70Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts