gebhart/patrepeval huggingface dataset:
Iodoindazoles with Selective Magnesiation at Position 3: A Route to Highly Functionalized Indazoles (2016)

A unique route to highly functionalized indazoles is described. A regioselective magnesiation at position 3 of 4-, 5-, 6- and 7-iodo-2-THP-indazoles (THP=tetrahydropyranyl) has been developed using TMPMgCl⋅LiCl (TMP=2,2,6,6-tetramethylpiperidyl). The obtained magnesiate can be trapped by different electrophiles to introduce a wide range of functional groups including halogens, thioalkyls, alcohols, aldehydes, ketones, amides, or esters at position 3. Once this position is functionalized, the iodine atoms can be further reacted through metal-halogen exchange or cross-coupling strategies. Finally, N-substitution reactions allow the synthesis of a variety of highly functionalized indazoles giving access to these valuable scaffolds through a simple and unique route.
A new architecture for digital time domain beamforming (1987)

This paper introduces a new approach to an architecture for digital time domain beamforming. The approach is unique as it produces sufficient beams to cover the observation space both simultaneously and continuously. Two implementation techniques are discussed; the first is a single chip beamformer based on a multibus architecture; the second is a multichip network-based architecture. The upper constraint on the number of sensors N, handled by a chip or chip set, is imposed by VLSI considerations. In both approaches, an additional chip has been identified which permits a number of systems, each supporting N sensors, to be combined to support larger numbers of sensors. The features of the architecture which permit this extension are the distributed memory and the reconfigurability of the modules. A two-dimensional FFT beamformer system performs a temporal FFT to separate out the frequencies and then performs a spatial FFT to determine the direction of the source(s) at specific frequencies. The beams produced by the new architecture contain all the signal frequencies which originate along the maximum response axis (MRA) of the beams. Therefore, an FFT may be performed on each beam to determine the frequencies of the signal sources. From this point of view, the new architecture eliminates the need for the temporal FFT required in the two-dimensional FFT beamformer. The processing power replaced by the architecture, assuming a system with 1024 beams, and a maximum signal frequency of 10 kHz, is 820 megafloating point operations per second (MFLOPS).
Q tomography towards true amplitude image and improve sub-karst image (2012)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 2012Q tomography towards true amplitude image and improve sub-karst imageAuthors: Yang HeJun CaiYang HeTGS and Jun CaiTGShttps://doi.org/10.1190/segam2012-1220.1 SectionsSupplemental MaterialAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Abstract A frequency domain tomographic inversion was developed to estimate frequency dependent energy attenuation by using prestack depth migration common image gathers (CIGs). The frequency dependent attenuation is estimated from the centroid frequency difference for reflections in CIGs. Migration stretch and ghost effects are taken into account to get correct measurements of frequency. This method makes correction for these factors to obtain correct frequency difference, utilizes the actual ray paths and avoids using amplitude information. It is relatively insensitive to some of amplitude loss factors, such as geometric spreading, reflection and transmission loss, source and receiver radiation patterns. Q tomography was used to derive the Q model for karst media. The compensation of amplitude loss improves the sub-karst amplitude fidelity. Permalink: https://doi.org/10.1190/segam2012-1220.1FiguresReferencesRelatedDetailsCited ByImproving seismic QP estimation using rock-physics constraintsYi Shen, Jack Dvorkin, and Yunyue Li9 April 2018 | GEOPHYSICS, Vol. 83, No. 3Final laser-beam Q-migrationXiang Xiao*, Feng Hao, Christopher Egger, Bin Wang, Fangxiang Jiao, and Xinling Wang5 August 2014Q-compensated reverse-time migrationTieyuan Zhu, Jerry M. Harris, and Biondo Biondi12 March 2014 | GEOPHYSICS, Vol. 79, No. 3 SEG Technical Program Expanded Abstracts 2012ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 2012 Pages: 4609 Publisher:Society of Exploration Geophysicists HistoryPublished: 25 Oct 2012 CITATION INFORMATION Yang He and Jun Cai, (2012), "Q tomography towards true amplitude image and improve sub-karst image," SEG Technical Program Expanded Abstracts : 1-5. https://doi.org/10.1190/segam2012-1220.1 Plain-Language Summary PDF DownloadLoading ...
Passive Static Equilibrium with Frictional Contacts and Application to Grasp Stability Analysis (2018)

This paper studies the problem of passive grasp stability under an external disturbance, that is, the ability of a grasp to resist a disturbance through passive responses at the contacts. To obtain physically consistent results, such a model must account for friction phenomena at each contact; the difficulty is that friction forces depend in non-linear fashion on contact behavior (stick or slip). We develop the first polynomialtime algorithm which either solves such complex equilibrium constraints for two-dimensional grasps, or otherwise concludes that no solution exists. To achieve this, we show that the number of possible "slip states" (where each contact is labeled as either sticking or slipping) that must be considered is polynomial (in fact quadratic) in the number of contacts, and not exponential as previously thought. Our algorithm captures passive response behaviors at each contact, while accounting for constraints on friction forces such as the maximum dissipation principle.
Transmission through carbon nanotubes with polyhedral caps (2000)

We study electron transport between capped carbon nanotubes and a substrate, and relate the transmission probability to the local density of states in the cap. Our results show that the transmission probability mimics the behavior of the density of states at all energies except those that correspond to localized states in the cap. Close proximity of a substrate causes hybridization of the localized state. As a result, transmission paths open from the substrate to nanotube continuum states via the localized states in the cap. Interference between various transmission paths gives rise to antiresonances in the transmission probability, with the minimum transmission equal to zero at energies of the localized states. Defects in the nanotube that are placed close to the cap cause resonances in the transmission probability, instead of antiresonances, near the localized energy levels. Depending on the spatial position of defects, these resonant states are capable of carrying a large current. These results are relevant to carbon nanotube based studies of molecular electronics and probe tip applications.
Melodías de cine (2002)

El articulo analiza la definicion del genero musical y establece un recorrido por su historia, observando la evolucion del cine musical desde la llegada del cine sonoro, hasta las representaciones contemporaneas.
Computer animation of the sphere eversion (1975)

article Free Access Share on Computer animation of the sphere eversion Authors: Nelson L. Max Case Western Reserve University Case Western Reserve UniversityView Profile , William H. Clifford Case Western Reserve University Case Western Reserve UniversityView Profile Authors Info & Claims ACM SIGGRAPH Computer GraphicsVolume 9Issue 1Spring 1975 pp 32–39https://doi.org/10.1145/964963.563736Published:01 April 1975Publication History 9citation553DownloadsMetricsTotal Citations9Total Downloads553Last 12 Months11Last 6 weeks2 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Catalytic Antibodies: Hapten Design Strategies and Screening Methods (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Synthèse stéréo- et regiosélective de pyrroloisothiochromane et pyrrolobenzo-[d]thiepine (2002)

International audience
Nonhistone chromosomal proteins of rat tissues. Comparative study by gel electrophoresis (1973)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNonhistone chromosomal proteins of rat tissues. Comparative study by gel electrophoresisFlora C. Wu, Sarah C. R. Elgin, and Leroy E. HoodCite this: Biochemistry 1973, 12, 15, 2792–2797Publication Date (Print):July 1, 1973Publication History Published online1 May 2002Published inissue 1 July 1973https://pubs.acs.org/doi/10.1021/bi00739a003https://doi.org/10.1021/bi00739a003research-articleACS PublicationsRequest reuse permissionsArticle Views23Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Growth Behaviors of High ${\rm J}_{\rm c}$${\rm Gd}_{1+{\rm x}}{\rm Ba}_{2-{\rm x}}{\rm Cu}_{3}{\rm O}_{7}$ Coated Conductors on IBAD-MgO Templates Probed by X-Ray Diffraction and Raman Scattering Spectroscopy (2009)

Gd <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1+x</sub> Ba <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2-x</sub> Cu <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">7</sub> (GdBCO) coated conductors on Ion-beam assisted deposition (IBAD)-MgO templates were grown by pulsed laser deposition (PLD). Growth conditions for the PLD of high quality of GdBCO turn out to have a rather larger range than for Nd-based cuprate thin films. The structural properties and critical current of GdBCO have been measured. The GdBCO layers show ~ 100 A/cm at 0.5 micron-thick films. In our measurement of Raman scattering spectroscopy from 180 ~ 1,200 cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> , one strong B <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1g</sub> mode and two strong A <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1g</sub> modes were observed. The high critical-current is ascribed to well-grown highly textured 123-structure without cation disorder and oxygen deficiency. It is notable that the GdBCO films do not have second phases like BaCuO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> , which is a signature liquid phase-based material that occurs in other rare-earth based cuprates.
The human equilibrative nucleoside transporter 1 mediates in vitro cytarabine sensitivity in childhood acute myeloid leukaemia (2005)

Cytarabine (ara-C) is the most effective agent for the treatment of acute myeloid leukaemia (AML). Aberrant expression of enzymes involved in the transport/metabolism of ara-C could explain drug resistance. We determined mRNA expression of these factors using quantitative-real-time-PCR in leukemic blasts from children diagnosed with de novo AML. Expression of the inactivating enzyme pyrimidine nucleotidase-I (PN-I) was 1.8-fold lower in FAB-M5 as compared to FAB-M1/2 (P=0.007). In vitro sensitivity to deoxynucleoside analogues was determined using the MTT-assay. Human equilibrative nucleoside transporter-1 (hENT1) mRNA expression and ara-C sensitivity were significantly correlated (rp=-0.46; P=0.001), with three-fold lower hENT1 mRNA levels in resistant patients (P=0.003). hENT1 mRNA expression also seemed to correlate inversely with the LC50 values of cladribine (rp=-0.30; P=0.04), decitabine (rp=-0.29; P=0.04) and gemcitabine (rp=-0.33; P=0.02). Deoxycytidine kinase (dCK) and cytidine deaminase (CDA) mRNA expression seemed to correlate with in vitro sensitivity to gemcitabine (rp=-0.31; P=0.03) and decitabine (rp=0.33; P=0.03), respectively. The dCK/PN-I ratio correlated inversely with LC50 values for gemcitabine (rp=-0.45, P=0.001) and the dCK/CDA ratio seemed to correlate with LC50 values for decitabine (rp=-0.29; 0.04). In conclusion, decreased expression of hENT1, which transports ara-C across the cell membrane, appears to be a major factor in ara-C resistance in childhood AML.
An analysis of heavy chain glycopeptides of hybridoma antibodies: correlation between antibody specificity and sialic acid content. (1981)

Abstract Analysis of the glycopeptides of IgA hybridoma proteins by using Tris-borate gels has shown that for mouse α-chain the carbohydrate structure depends on the specificity of the antibody and on the strain of mouse from which the hybridoma was derived. IgA antibodies specific for α1 → 3-linked dextran have sialic acid on all or virtually all of their glycopeptides. IgA antibodies specific for α1 → 6 dextran produced by BALB/c mice have sialic acid only on a small subset of their glycopeptides. However, IgA antibodies specific for α1 → 6 dextran produced by C57BL/6 mice have sialic acid on most of their glycopeptides.
Identification of 6-O-acetyl-d-glucopyranose in Bacillus megaterium cultures. Synthesis of 6-O-acetyl-d-glucopyranose and 6-O-acetyl-d-galactopyranose (1958)

Research Article| November 01 1958 Identification of 6-O-acetyl-d-glucopyranose in Bacillus megaterium cultures. Synthesis of 6-O-acetyl-d-glucopyranose and 6-O-acetyl-d-galactopyranose R. B. Duff; R. B. Duff 1Departments of Biochemistry and Spectrochemistry, The Macaulay Institute for Soil Research Aberdeen, Scotland Search for other works by this author on: This Site PubMed Google Scholar V. C. Farmer V. C. Farmer 1Departments of Biochemistry and Spectrochemistry, The Macaulay Institute for Soil Research Aberdeen, Scotland Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1958) 70 (3): 515–520. https://doi.org/10.1042/bj0700515 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation R. B. Duff, V. C. Farmer; Identification of 6-O-acetyl-d-glucopyranose in Bacillus megaterium cultures. Synthesis of 6-O-acetyl-d-glucopyranose and 6-O-acetyl-d-galactopyranose. Biochem J 1 November 1958; 70 (3): 515–520. doi: https://doi.org/10.1042/bj0700515 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1958 CAMBRIDGE UNIVERSITY PRESS1958 Article PDF first page preview Close Modal You do not currently have access to this content.
ChemInform Abstract: Synthesis and anti‐HIV Activity of Carbocyclic Ring‐Enlarged 4′,1′a‐Methano Oxetanocin Analogues. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Structured visual markers for indoor pathfinding (2003)

We present a mobile augmented reality (AR) system to guide a user through an unfamiliar building to a destination room. The system presents a world-registered wireframe model of the building labeled with directional information in a see-through heads-up display, and a three-dimensional world-in-miniature (WIM) map on a wrist-worn pad that also acts as an input device. Tracking is done using a combination of wall-mounted ARToolkit markers observed by a head-mounted camera, and an inertial tracker. To allow coverage of arbitrarily large areas with a limited set of markers, a structured marker re-use scheme based on graph coloring has been developed.
Marginalizing Sample Consensus (2021)

A new method for robust estimation, MAGSAC++, is proposed. It introduces a new model quality (scoring) function that does not make inlier-outlier decisions, and a novel marginalization procedure formulated as an M-estimation with a novel class of M-estimators (a robust kernel) solved by an iteratively re-weighted least squares procedure. Instead of the inlier-outlier threshold, it requires only its loose upper bound which can be chosen from a significantly wider range. Also, we propose a new termination criterion and a technique for selecting a set of inliers in a data-driven manner as a post-processing step after the robust estimation finishes. On a number of publicly available real-world datasets for homography, fundamental matrix fitting and relative pose, MAGSAC++ produces results superior to the state-of-the-art robust methods. It is more geometrically accurate, fails fewer times, and it is often faster. It is shown that MAGSAC++ is significantly less sensitive to the setting of the threshold upper bound than the other state-of-the-art algorithms to the inlier-outlier threshold. Therefore, it is easier to be applied to unseen problems and scenes without acquiring information by hand about the setting of the inlier-outlier threshold. The source code and examples both in C++ and Python are available at https://github.com/danini/magsac.
Environmental information document: Savannah River Laboratory Seepage Basins (1987)

This document provides environmental information on postulated closure options for the Savannah River Laboratory Seepage Basins at the Savannah River Plant and was developed as background technical documentation for the Department of Energy`s proposed Environmental Impact Statement (EIS) on waste management activities for groundwater protection at the plant. The results of groundwater and atmospheric pathway analyses, accident analysis, and other environmental assessments discussed in this document are based upon a conservative analysis of all foreseeable scenarios as defined by the National Environmental Policy Act (CFR, 1986). The scenarios do not necessarily represent actual environmental conditions. This document is not meant to be used as a closure plan or other regulatory document to comply with required federal or state environmental regulations.
Monodisperse Surface-Charge-Controlled Black Nanoparticles for Near-Infrared Shielding (2019)

A simple and quick preparation of black polymer nanoparticles by the microwave-assisted polymerization of 1,5-dihydroxynaphthalene and 1,3,5-trimethyl-1,3,5-triazinane under high temperature and pressure was demonstrated. The average diameter of the nanoparticles ranged from 20 to 700 nm, depending on the preparation conditions such as reaction solvent, monomer concentrations, and monomer ratio in the seed mixture. The surface charge of the nanoparticles was also determined by the monomer ratio used in the seed mixture. The nanoparticles could be dispersed in polar solvents such as water, methanol, and ethanol, probably because the phenolic hydroxyl groups and primary/secondary amine groups remained on the surface of the nanoparticles. The reflectance spectroscopic measurements from 200 to 2200 nm showed that the nanoparticles expressed selective reflectivity of NIR wavelengths. The absorption and reflectance properties could be tuned by microwave-assisted wet calcination of the nanoparticles. The particles were initially dark green, but when the particles were heated at 250 °C for 10 min in ethylene glycol, they absorbed light in the UV–visible region (reflectance was less than 3% from 200 to 750 nm), indicating the color of the particles had become perfectly black. Reflection in the NIR region from 1250 to 2150 nm, however, remained more than 50% after calcination. The calcinated nanoparticles could be dispersed in water, and the surface charge was positive at lower pH and negative at higher pH. The isoelectric point shifted slightly from 5.3 to 4.4 after wet calcination at 250 °C. The amount of nitrogen in the nanoparticles decreased remarkably after calcination; therefore, the phenolic hydroxyl groups must have remained on the surface of the calcinated nanoparticles preferentially to the amine groups. These black nanoparticles with selective reflectance in the NIR region could be applied to black heat-shielding materials such as paints for buildings and automobiles.
The role of magnetization transfer in the observed contrast in T1 weighted imaging under clinical setups (2017)

In T<sub>1</sub> weighted magnetic resonance imaging of brain and spinal cord in the clinical setting, the white matter (WM) appears with greater intensity than the gray matter (GM). This contrast has been assigned to differences in T<sub>1</sub> values. In these experiments the RF pulses are too long to excite both the water and the species with restricted motion of the protons (SRMP). In in vitro studies using short RF pulses, the contrast is reversed, with greater intensity for the GM. These results raise the question of whether magnetization transfer (MT) plays a role in the contrast observed in the T<sub>1</sub> weighting experiments. In the present work we implemented selective saturation recovery alone and together with the conventional magnetization transfer contrast (MTC) method. The results confirm that a major factor that determines the characteristic WM/GM averaged intensity ratio observed in T<sub>1</sub> weighted imaging under clinical conditions is MT between the SRMP and water. When selective saturation recovery is combined with MTC, the SRMP yields spectral widths ranging from a few to tens of kilohertz, indicating that more than one type of SRMP is involved in the MT. The z-spectrum obtained with this combination is free of the effect of direct saturation of the water peak. Selective saturation recovery enables an independent measurement of the exchange time and T<sub>1</sub> , while the combination with MTC with complete saturation of the SRMP enables measurement of T<sub>1</sub> without the effect of MT. The latter measurement can be carried out on a timescale much shorter than T<sub>1.</sub>