gebhart/patrepeval huggingface dataset:
The pharmacokinetics, pharmacodynamics, and safety of baricitinib, an oral JAK 1/2 inhibitor, in healthy volunteers (2014)

Baricitinib (also known as LY3009104 or INCB028050), a novel and potent small molecule inhibitor of Janus kinase family of enzymes (JAKs) with selectivity for JAK1 and JAK2, is currently in clinical development for the treatment of rheumatoid arthritis (RA) and other inflammatory disorders. Two double-blind, randomized, and placebo-controlled studies were conducted to evaluate single ascending doses of 1-20 mg and multiple ascending doses of 2-20 mg QD and 5 mg BID for 10 or 28 days in healthy volunteers. Following oral administration, baricitinib plasma concentration typically attains its peak value within 1.5 hours postdose and subsequently declines in a bi-exponential fashion. Baricitinib demonstrates dose-linear and time-invariant pharmacokinetics, with low oral-dose clearance (17 L/h) and minimal systemic accumulation observed following repeat dosing. The mean renal clearance of baricitinib was determined to be ∼2 L/h. The effect of a high-fat meal on baricitinib pharmacokinetics was insignificant. The pharmacodynamics of baricitinib, evaluated by the inhibition of STAT3 phosphorylation following cytokine stimulation in the whole blood ex vivo, was well correlated with baricitinib plasma concentrations. Baricitinib was generally safe and well tolerated, with no serious treatment-related adverse events (AEs) reported from either of the studies. An expected rapidly reversible, dose-related decline in absolute neutrophil count was seen with baricitinib.
[Use of radiolabeled monoclonal antibodies for diagnostic imaging]. (1990)

Monoclonal antibodies (MoAbs) are expected to carry radionuclides selectively to target tissues and to offer antigen-specific diagnosis. Indium (In)-111 has many favorable nuclear properties and is efficiently labeled with MoAbs using DTPA as a bifunctional chelating agent. In-111 labeled MoAbs are clinically employed for the diagnosis of malignant melanoma, colorectal cancer and acute myocardial infarction in Japan. Although non-specific deposit of In-111 was seen in liver and bone-marrow, scintigraphy using In-111 labeled MoAbs was encouraging, since it detected about 80% of tumors, tumors missed by conventional diagnostic methods such as CT, and tumors in patients with normal serum CEA values, and acute myocarditis as well as acute myocardial infarction was positive with In-11 labeled Fab fraction of anti-myosin Ab. Acute or subacute toxicity was not observed. Human anti-murine antibody (HAMA) was detected in 53 of 64 (82.8%) patients who were intravenously administered with 20 to 42 mg of anti-melanoma or anti-CEA MoAbs (whole IgG). In contrast, only 5 of 406 (1.2%) patients had detectable levels of HAMA in their serum after receiving 0.5 mg of Fab fraction of MoAb. Recently mouse-human chimeric Ab has been produced by recombinant DNA techniques, which localized well in xenografted tumors and seems to be promising for clinical use. Investigations are under way to increase the tumor to non-tumor ratio by modifying chelating agents for coupling MoAbs with radionuclides.
The Stimulus-Secretion Coupling of Amino Acid-Induced Insulin Release XI. Kinetics of Deamination and Transamination Reactions (1982)

L-Leucine and its nonmetabolized analogue, 2-aminobicyclo-[2,2,1]heptane-2-carboxylic acid (BCH) activate glutamate dehydrogenase in pancreatic islets, whether the reaction velocity is measured in the direction of glutamate synthesis or glutamate deamination. The rate of glutamate oxidative deamination is increased by ADP and inhibited by 2-ketoglutarate, NH4+ and GTP. The islet homogenate catalyzes the transamination between L-glutamate and either 2-ketoisocaproate or pyruvate, and between 2-ketoglutarate and L-leucine, L-aspartate, L-alanine, L-isoleucine, L-valine, L-norvaline or L-norleucine, but not b (+/-) BCH. The glutamate-aspartate transaminase is preferentially located in mitochondria relative to other transaminases. The parallel effects of L-leucine and BCH on glutamate dehydrogenase and their vastly different abilities to act as transamination partners may account for both analogies and discrepancies in the metabolic and functional responses of the islets to these two branched-chain amino acids.
Sequence Analysis of the Genes Encoding the Phosphoprotein of Recent Isolates of Canine Distemper Virus in Japan. (2000)

The nucleotide sequences of the phosphoprotein (P) of canine distemper virus (CDV) strains isolated between 1992 and 1996 in Japan were determined. This is the first report of the complete sequences of the P genes of recently prevalent CDV strains. The deduced amino acid sequences of the P, C and V proteins showed that in the new Japanese isolates, these proteins have approximately 93%, 90-91% and 92% identities with those of the Onderstepoort vaccine strain, respectively. The predicted functional regions were conserved. RNA editing resulting in a shift to the open reading frame (ORF) of the V protein was shown to occur with the same efficiency in both the field isolates and vaccine strain.
Spectres d'absorption X dans les plasmas femtosecondes (2005)

Nous avons mesur le spectre d'absorption en couche K de plasmas d'aluminium haute densit. Deux faisceaux de la chane laser femtoseconde 100 TW du LULI (de dure 300 fs) ont t utiliss pour produire le plasma absorbant sur une feuille mince d'Al (830 ou 500 ), et la source de radiographie sur du samarium massif. Les spectres X taient rsolus spatialement dans une direction perpendiculaire la direction de la dispersion spectrale. Les spectres ont t mesurs pour diffrents retards entre la source de radiographie et le plasma d'Al. Des simulations des spectres et de l'ionisation en fonction du temps et de l'intensit, obtenues au moyen de codes hydrodynamiques et de structure atomique, montrent un bon accord avec les rsultats exprimentaux.
RECOMMENDATIONS FOR AN ACCEPTANCE AND VERIFICATION TEST OF OPTICAL 3-D MEASUREMENT SYSTEMS (2000)

The paper reports on the development of a new guideline for acceptance and verification of optical 3-D measuring system, e.g. photogrammetric systems or fringe-projection systems. The work has started in 1996, initiated by the working group “Close-range Photogrammetry” of the German Society for Photogrammetry and Remote Sensing (DGPF) and by the working group “Co-ordinate measuring machines” of the German Society for measurement and automatic control (VDI/VDE-GMA). A new VDI working group has been established joining almost all important users and manufacturers of optical 3-D systems. The new guideline VDI 2634 proposes procedures for the acceptance of point-wise photogrammetric systems (part 1), and area-based surface measurement systems (part 2). For both groups of systems the “error of length measurement” has been selected as the most significant criterion for an over all performance assessment. Surface measurement systems shall also be checked according to “error of flatness measurement” and “probing error”. Suitable calibrated reference objects are proposed as well.
The pho regulon-dependent Ugp uptake system for glycerol-3-phosphate in Escherichia coli is trans inhibited by Pi (1994)

sn-Glycerol-3-phosphate (G3P) or glyceryl phosphoryl phosphodiesters, the substrates of the phoB-dependent Ugp transport system, when transported exclusively through this system, can serve as a sole source of phosphate but not as a sole source of carbon (H. Schweizer, M. Argast, and W. Boos, J. Bacteriol. 150:1154-1163, 1982). In order to explain this phenomenon, we tested two possibilities: repression of the pho regulon by Ugp-mediated transport and feedback inhibition by internal G3P or its degradation product Pi. Using an ugp-lacZ fusion, we found that the expression of ugp does not decline upon exposure to G3P, in contrast to the repressing effect of transport of Pi via the Pst system. This indicated that the Ugp system becomes inhibited after the uptake and metabolism of G3P. Using 32P-labeled G3P, we observed that little Pi is released by cells taking up G3P via the Ugp system but large amounts of Pi are released when the cells are taking up G3P via the GlpT system. Using a glpD mutant that could not oxidize G3P but which could still phosphorylate exogenous glycerol to G3P after GlpF-mediated transport of glycerol, we could not find trans inhibition of Ugp-mediated uptake of exogenous 14C-G3P. However, when allowing uptake of Pi via Pst, we observed a time-dependent inhibition of 14C-G3P taken up by the Ugp transport system. Inhibition was half maximal after 2 min and could be elicited by Pi concentrations below 0.5 mM. Cells had to be starved for Pi in order to observe this inhibition. We conclude that the activity of the Ugp transport system is controlled by the level of internal phosphate.
Ordered Kronecker functional decision diagrams-a data structure for representation and manipulation of Boolean functions (1998)

Ordered Kronecker functional decision diagrams (OKFDD's) are a data structure for efficient representation and manipulation of Boolean functions. OKFDD's are a generalization of ordered binary decision diagrams (OBDD)s) and ordered functional decision diagrams and thus combine the advantages of both. In this paper, basic properties of OKFDD's and their efficient representation and manipulation are given. Starting with elementary manipulation algorithms, we present methods for the construction of small OKFDD's. Our approach is based on dynamic variable ordering and decomposition-type choice. For changing the decomposition type, we use an efficient reordering-based method. We briefly discuss the implementation of PUMA, an OKFDD package, which was used in all our experiments. These experiments demonstrate the quality of our methods in comparison to sifting and interleaving for OBDD's.
Analysis on the Secondary Carbonization Experiment and the Rule of Temperature Field Evolvement of Coal Sample (2011)

Abstract The coal sample preparation is an important part for the study of coal's character, and therefore, the man-made secondary carbonization method of coal sample preparation was explored in the text. Firstly, the scheme of secondary carbonization was designed, and then, according to it, the heat transmission and the temperature field evolvement rule were analyzed in the process of carbonization. Finally, the secondary carbonization experiment of coal sample preparation was conducted, and the coal sample was obtained successfully. The results show that the temperature rise velocity in the center of coal sample is from fast to slow in the process of secondary carbonization, and the reasonable calefaction time is about 15000 seconds.
Data Efficient Lithography Modeling with Residual Neural Networks and Transfer Learning (2018)

Lithography simulation is one of the key steps in physical verification, enabled by the substantial optical and resist models. A resist model bridges the aerial image simulation to printed patterns. While the effectiveness of learning-based solutions for resist modeling has been demonstrated, they are considerably data-demanding. Meanwhile, a set of manufactured data for a specific lithography configuration is only valid for the training of one single model, indicating low data efficiency. Due to the complexity of the manufacturing process, obtaining enough data for acceptable accuracy becomes very expensive in terms of both time and cost, especially during the evolution of technology generations when the design space is intensively explored. In this work, we propose a new resist modeling framework for contact layers that utilizes existing data from old technology nodes to reduce the amount of data required from a target lithography configuration. Our framework based on residual neural networks and transfer learning techniques is effective within a competitive range of accuracy, i.e., 2-10X reduction on the amount of training data with comparable accuracy to the state-of-the-art learning approach.
Modelling the Positional and Orientation Sensitivity of Inductively Coupled Sensors for Industrial IoT Applications (2017)

As the Internet of Things (IoT) sector continually expands there is a growing abstraction between physical objects and&#13;\nthe data associated with them. At the same time, emerging Industrial-IoT applications rely upon diverse and robust hardware&#13;\nsensing interfaces in order to deliver high quality data. In this paper, the fundamental limitations associated with inductive&#13;\nproximity sensing interfaces are considered in terms of positional and orientation sensitivity and a triaxial approach is proposed&#13;\nthat enables arbitrary source-sensor positioning. A matrix transformation model based on the field coupling equations is applied to&#13;\na number of candidate configurations assessed according their relative source-sensor coverage and graphical visualization of&#13;\ncoupling quality. Particular attention is paid to the recombination of tri-sensor outputs involving direct-summation, rectifysummation,&#13;\nbest-coil and root-mean-square methods. Of these, the rectify-summation method was observed to provide favorable&#13;\nperformance, exceeding 70% coverage for practical cases, thus far exceeding that of traditional co-planar arrangements.
Automated generation of the design solution of the assembly in instrument engineering (2018)

The paper deals with the specific nature of assembly processes in instrument-making and considers the current state of development of computer-aided design technology assembly and their suitability for conditions of instrument making production. In addition, we develop the mathematical model of the assembly product in instrument-making taking into account complexity and specificity of the assembly, adjustment and test work. We propose the method of forming the model describing the structure of the assembly product which represents it as a hierarchical system of interconnected structural elements. The proposed model is integrated in the CAD system. It is informative and suitable for the process of automated assembly design. Relying on the proposed method describing the product structure we develop the software AsCAM containing the procedures and database design and technology information. This software can effectively solve the problem of technology preparation of small-scale assembly plant in construction of the circuit assembly of the product and flow diagram of assembly.
Characterization of OCO-2 and ACOS-GOSAT biases and errors for CO&lt;sub&gt;2&lt;/sub&gt; flux estimates (2019)

Abstract. We characterize the magnitude of seasonally and spatially varying biases in the National Aeronautics and Space Administration (NASA) Orbiting Carbon Observatory-2 (OCO-2) Version 8 (v8) and the Atmospheric CO2 Observations from Space (ACOS) Greenhouse Gas Observing SATellite (GOSAT) version 7.3 (v7.3) satellite CO2 retrievals by comparisons to measurements collected by the Total Carbon Column Observing Network (TCCON), Atmospheric Tomography (ATom) experiment, and National Oceanic and Atmospheric Administration (NOAA) Earth System Research Laboratory (ESRL) and U. S. Department of Energy (DOE) aircraft, and surface stations. Although the ACOS-GOSAT estimates of the column averaged carbon dioxide (CO2) dry air mole fraction (XCO2) have larger random errors than the OCO-2 XCO2 estimates, and the space-based estimates over land have larger random errors than those over ocean, the systematic errors are similar across both satellites and surface types, 0.6 ± 0.1 ppm. We find similar estimates of systematic error whether dynamic versus geometric coincidences or ESRL/DOE aircraft versus TCCON are used for validation (over land), once validation and co-location errors are accounted for. We also find that areas with sparse throughput of good quality data (due to quality flags and preprocessor selection) over land have ~double the error of regions of high-throughput of good quality data. We characterize both raw and bias-corrected results, finding that bias correction improves systematic errors by a factor of 2 for land observations and improves errors by ~ 0.2 ppm for ocean. We validate the lowermost tropospheric (LMT) product for OCO-2 and ACOS-GOSAT by comparison to aircraft and surface sites, finding systematic errors of ~ 1.1 ppm, while having 2–3 times the variability of XCO2. We characterize the time and distance scales of correlations for OCO-2 XCO2 errors, and find error correlations on scales of 0.3 degrees, 5–10 degrees, and 60 days. We find comparable scale lengths for the bias correction term. Assimilation of the OCO-2 bias correction term is used to estimate flux errors resulting from OCO-2 seasonal biases, finding annual flux errors on the order of 0.3 and 0.4 PgC/yr for Transcom-3 ocean and land regions, respectively.
Exploring the Interactions Between Caffeic Acid and Human Serum Albumin Using Spectroscopic and Molecular Docking Techniques (2021)

In fruits, it may constitute up to 70% of the total HCAs content The relatively good bioavailability of CA makes it possible to interact with human serum albumin (HSA) in the body In a cross-over study with 4 female and 3 male healthy ileostomy subjects, 95% of the ingested caffeic acid was absorbed from the small intestine in humans CA possesses different biological activities, such as antioxidant properties due to its high radical scavenging activity, and antimutagenic, anti-inflammatory, antidepressant, antimetastatic, anticarcinogenic, HIV replication-inhibitory, and antianxiety activities Additionally, CA has been reported to induce apoptosis in cancerous cells and inhibit tumor proliferation in animal models CA
EVAPORATION CHARACTERISTICS OF Se/Te ALLOYS AS APPLIED TO PHOTORECEPTORS (1988)

Abstract Xerographic devices obtained by vacuum deposition of SeTe alloys have inhomogeneities in stoichiometry because of the differences in vapor pressures of the individual elements. As a result the concentration of Te on the top surface of the devices is considerably higher than the rest of the film. This is termed as “fractionation”. It has been observed that the fractionation characteristics of the SeTe alloys are dependent on the quenching temperature during the alloy preparation which in turn affects the electrical properties of the photoreceptors.
Influence de raidisseurs longitudinaux sur la diffusion acoustique par un tube : théorie et expérience (2000)

CE TRAVAIL PORTE SUR L'INFLUENCE DE RAIDISSEURS LONGITUDINAUX SUR LA DIFFUSION ACOUSTIQUE PAR UN TUBE IMMERGE, SOUS INCIDENCE NORMALE. UN MODELE THEORIQUE ORIGINAL EST DEVELOPPE EN S'APPUYANT SUR LA THEORIE DE L'ELASTICITE. L'INFLUENCE DES RAIDISSEURS EST PRISE EN COMPTE PAR L'INTERMEDIAIRE DES CONTRAINTES IMPOSEES PONCTUELLEMENT PAR LES RAIDISSEURS SUR LA SURFACE INTERNE DU TUBE. LES OBJETS ETUDIES SONT EN ACIER INOXYDABLE, DE RAPPORTS DES RAYONS INTERNE SUR EXTERNE B/A EGAUX A 0,97 ET 0,98. LA VALIDATION EXPERIMENTALE EST EFFECTUEE AVEC PLUSIEURS CIBLES, OU LE RAIDISSEUR CORRESPOND A UNE SUREPAISSEUR (SOUDURE), A UNE PLAQUE INTERNE DIAMETRALE ATTACHEE D'UN SEUL COTE, PUIS ATTACHEE DES DEUX COTES. LES ETUDES SONT EFFECTUEES D'UN POINT DE VUE THEORIQUE (ANALYTIQUE), NUMERIQUE ET EXPERIMENTAL, AUTANT DANS LE DOMAINE DES BASSES FREQUENCES (5-35 EN FREQUENCE REDUITE K 1A, K 1 ETANT LE NOMBRE D'ONDE DANS L'EAU) QUE DANS CELUI DES MOYENNES ET HAUTES FREQUENCES (K 1A COMPRIS ENTRE 30-150). LES ANALYSES DES SPECTRES FREQUENTIELS ET DES REPONSES TEMPORELLES MONTRENT QUE LA DISCONTINUITE DU MILIEU DE PROPAGATION, CREEE PAR LA JONCTION ENTRE LE TUBE ET LA STRUCTURE INTERNE, JOUE UN ROLE TRES IMPORTANT. EN EFFET, CETTE JONCTION PROVOQUE DES PHENOMENES DE REFLEXION, DE GENERATION ET DE CONVERSION DES ONDES CIRCONFERENTIELLES SE PROPAGEANT AUTOUR DU TUBE. LES PHENOMENES DE CONVERSIONS D'ONDES SONT CLAIREMENT MIS EN EVIDENCE, D'UNE PART, DANS LE MODELE THEORIQUE DEVELOPPE, OU CHAQUE MODE DE VIBRATION EST COUPLE AUX AUTRES, ET D'AUTRE PART, SUR LES REPRESENTATIONS FREQUENCE/NOMBRE D'ONDE. PAR RAPPORT AUX TUBES NON RAIDIS, DE NOUVELLES RESONANCES APPARAISSENT ET LEUR PROVENANCE A ETE IDENTIFIEE ; CES RESONANCES SONT LIEES A L'INTERACTION ENTRE LE TUBE ET LA STRUCTURE INTERNE. LES ETUDES DETAILLEES DES PHENOMENES MIS EN JEU LORS DE LA DIFFUSION ACOUSTIQUE MONTRENT BIEN QUE L'INFLUENCE DES JONCTIONS EST AUSSI IMPORTANTE QUE LA NATURE DE LA STRUCTURE INTERNE.
Development of Cys38 knock-out and humanized version of NbAahII10 nanobody with improved neutralization of AahII Scorpion toxin (2011)

During scorpion envenoming, highly toxic small polypeptides of the venom diffuse rapidly within the victim, causing serious medical problems. Nanobodies (Nbs), the recombinant single-domain antigen-binding fragments of camel-specific heavy-chain only antibodies, offer special advantages in therapy over classic antibody fragments due to their robustness and smaller size, matching the size of the scorpion toxins. Recently, a potent AahII scorpion toxin-neutralizing Nb was identified. However, this NbAahII10 contains a single Cys in its first antigen-binding loop, leading to Nb dimerization upon prolonged storage. In this work, we first investigate the efficacy of NbAahII10 variants in which this Cys was substituted by Ala, Ser or Thr. Second, the NbAahII10 Cys/Ser mutant displaying the best functional properties is subsequently humanized. It is demonstrated that the maximally humanized version of NbAahII10 Cys/Ser maintains its high affinity for the antigen without conceding much on expression yield and stability. More importantly, its neutralizing capacity is preserved as all mice survive injections of seven LD(50) and 50% of mice survived nine LD(50) of the scorpion toxin. Thus, this humanized Nb is the best candidate to develop a therapy in human against the most toxic venom compound of one of the most dangerous scorpions.
Genetic Studies on Plasmid-Linked Cadmium Resistance in Staphylococcus aureus (1972)

The genetic basis of cadmium resistance conferred by three penicillinase plasmids, PI(524), PI(258), and PII(147), of Staphylococcus aureus was examined by mutation, recombination, and deletion analysis. Three separate loci were identified: cadA, responsible for high-level resistance; cadB, giving a low-level resistance, nonadditive to cadA; and mad, a locus marginally decreasing the cadmium resistance of plasmid-positive staphylococci. The loci cadA and mad were present on all three plasmids, but cadB was only found on PII(147). Spontaneous deletions of mad involved up to three-fourths of the plasmid genome, which allowed derivation of a partial deletion map of PII(147), a plasmid with a contour length of 10.9 mum, corresponding to a molecular weight of 20.4 x 10(6).
Obstacle detection based on qualitative and quantitative 3D reconstruction (1997)

Three different algorithms for mobile robot vision-based obstacle detection are presented in this paper each based on different assumptions The first two algorithms are qualitative in that they return only yes/no answers regarding the presence of obstacles in the field of view; no 3D reconstruction is performed. They have the advantage of fast determination of the existence of obstacles in a scene based on the solvability of a linear system. The first algorithm uses information about the ground plane, while the second only assumes that the ground is planar. The third algorithm is quantitative in that it continuously estimates the ground plane and reconstructs partial 3D structures by determining the height above the ground plane of each point in the scene. Experimental results are presented for real and simulated data, and the performance of the three algorithms under different noise levels is compared in simulation. We conclude that in terms of the robustness of performance, the third algorithm is superior to the other two.