gebhart/patrepeval huggingface dataset:
SNPs within the GH-signaling pathway are associated with the early IGF1 response to GH replacement therapy in GHD adults (2013)

Our results indicate that common genetic variants in the GH signaling pathway may be of functional relevance to the response to GH replacement in GHD adults.
An integrated model in quality management, positioning TQM, BPR and ISO 9000 (1996)

Reviews developments in total quality management (TQM), business process re‐engineering (BPR) and world‐class manufacturing (WCM). Using modern systems, service quality and operations management theory, proposes an integrating model for managerial use which unifies existing approaches and helps managers navigate through the maze by presenting them with an integrating map. The model is called the Integrated Quality System. Compares the model with Beer’s five systems for viability. The Integrated Quality System enables the relative positions of TQM, BPR and ISO 9000 to be re‐appraised. It also incorporates systemic views of WCM. To date 35 organizations have been analysed using this model. The results have indicated many organizational deficiencies.
Depolymerization of polyamide 6 in hydrophilic ionic liquids (2019)

Polyamide 6 underwent an efficient depolymerization in hydrophilic ionic liquids under microwave irradiation at 300 °C. The depolymerization completed within 60 min. Caprolactam was readily separated by simple extraction procedure and the ionic liquids were recovered and reused for several times. Addition of catalytic amounts of DMAP (N,N-dimethylaminopyridine) promoted the depolymerization effectively. The present improved procedure provides a method to avoid direct distillation procedure, which consumes energy for the separation of caprolactam from ionic liquids. Although some contamination of ionic liquids was observed, the present procedure provides a new possibility for the use of ionic liquids for plastic chemical recycling from the viewpoint of development of an energy-saving methodology. Use of solubility switchable ionic liquids is also examined to explore a possibility for better separation although depolymerization did not work well.
Blood coagulation and the risk of atherothrombosis: a complex relationship. (2004)

The principles of Virchov's triad appear to be operational in atherothrombosis or arterial thrombosis: local flow changes and particularly vacular wall damage are the main pathophysiological elements. Furthermore, alterations in arterial blood composition are also involved although the specific role and importance of blood coagulation is an ongoing matter of debate. In this review we provide support for the hypothesis that activated blood coagulation is an essential determinant of the risk of atherothrombotic complications. We distinguish two phases in atherosclerosis: In the first phase, atherosclerosis develops under influence of "classical" risk factors, i.e. both genetic and acquired forces. While fibrinogen/fibrin molecules participate in early plaque lesions, increased activity of systemic coagulation is of no major influence on the risk of arterial thrombosis, except in rare cases where a number of specific procoagulant forces collide. Despite the presence of tissue factor - factor VII complex it is unlikely that all fibrin in the atherosclerotic plaque is the direct result from local clotting activity. The dominant effect of coagulation in this phase is anticoagulant, i.e. thrombin enhances protein C activation through its binding to endothelial thrombomodulin.The second phase is characterized by advancing atherosclerosis, with greater impact of inflammation as indicated by an elevated level of plasma C-reactive protein, the result of increased production influenced by interleukin-6. Inflammation overwhelms protective anticoagulant forces, which in itself may have become less efficient due to down regulation of thrombomodulin and endothelial cell protein C receptor (EPCR) expression. In this phase, the inflammatory drive leads to recurrent induction of tissue factor and assembly of catalytic complexes on aggregated cells and on microparticles, maintaining a certain level of thrombin production and fibrin formation. In advanced atherosclerosis systemic and vascular wall driven coagulation becomes more important and elevated levels of D-dimer fragments should be interpreted as markers of this hypercoagulability.
ChemInform Abstract: Solid‐Phase Peptide Synthesis: An Overview Focused on the Preparation of Biologically Relevant Peptides (2014)

Abstract Review: [74 refs.
Self-Powered Wireless Urinary-Incontinence Sensor System Detecting Urine Amount and Diaper Change Timing in Under 10 Minutes (2018)

A self-powered wireless urinary-incontinence sensor system composed of a wireless sensor and a receiver has been developed that detects the amount of urine and the time for a diaper change. The wireless urinary-incontinence sensor, which consists of a urine-activated battery, an intermittent power-supply circuit with a storage capacitor, and a wireless transmitter, makes it possible to detect the number of urinations and the amount of urine from the spacing between the output signals. The urine-activated battery, which consists of two long flexible electrodes embedded in a diaper and placed under a piece of absorbent material with a trench structure, makes fast detection of less than 10 minutes possible. A prototype urinary-incontinence sensor system detected the amount of urine in a diaper from the spacing between the sensing signals with a resolution of 100 em <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> and detected the time for a diaper change 7 minutes after urinations.
Consensus‐based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part II (2018)

This guideline was developed as a joint interdisciplinary European project, including physicians from all relevant disciplines as well as patients. It is a consensus-based guideline, taking available evidence from other guidelines, systematic reviews and published studies into account. This second part of the guideline covers antimicrobial therapy, systemic treatment, allergen-specific immunotherapy, complementary medicine, psychosomatic counselling and educational interventions, whereas the first part covers methods, patient perspective, general measures and avoidance strategies, basic emollient treatment and bathing, dietary intervention, topical anti-inflammatory therapy, phototherapy and antipruritic therapy. Management of AE must consider the individual clinical variability of the disease. Systemic immunosuppressive treatment with cyclosporine, methotrexate, azathioprine and mycophenolic acid is established option for severe refractory cases, and widely available. Biologicals targeting the T helper 2 pathway such as dupilumab may be a safe and effective, disease-modifying alternative when available. Oral drugs such as JAK inhibitors and histamine 4 receptor antagonists are in development. Microbial colonization and superinfection may cause disease exacerbation and can require additional antimicrobial treatment. Allergen-specific immunotherapy with aeroallergens may be considered in selected cases. Psychosomatic counselling is recommended especially in stress-induced exacerbations. Therapeutic patient education ('Eczema school') is recommended for children and adult patients. General measures, basic emollient treatment, bathing, dietary intervention, topical anti-inflammatory therapy, phototherapy and antipruritic therapy have been addressed in the first part of the guideline.
Randomized, Prospective, Placebo-Controlled Double-Blind Study of Dextrose Prolotherapy for Osteoarthritic Thumb and Finger (DIP, PIP, and Trapeziometacarpal) Joints: Evidence of Clinical Efficacy (2000)

Dextrose prolotherapy was clinically effective and safe in the treatment of pain with joint movement and range limitation in osteoarthritic finger joints.
Reading Habits of General Surgery Residents and Association With American Board of Surgery In-Training Examination Performance (2015)

Most residents reported reading consistently for patient care throughout the year. Daily studying and textbook use were associated with higher ABSITE scores on univariate analysis. Scores on the USMLE 2 and MCAT, as well as resident attitude regarding the importance of the ABSITE results, were independent predictors of ABSITE performance.
Mitochondrial Na+/Ca2+ Exchange Assays (2014)

Here, we describe two complementary assays designed to analyze mitochondrial Na(+)/Ca(2+) exchange activity. In both procedures, the counter ion transport of sodium and calcium ions across the inner membrane of mitochondria is assayed in permeabilized cells preloaded with a mitochondria-selective Na(+) probe, CoroNa-Red, or with a mitochondria-targeted calcium sensor, ratiometric-pericam, respectively. These methods, therefore, do not require a mitochondrial preisolation step, with the native cellular mitochondrial architecture being maintained. Importantly, these methods equilibrate the cytosol with the extracellular milieu to allow control over the extra-mitochondrial ionic environment, while eliminating any possible interference by plasma membrane transporters.
Graph spectral characterization of the XY model on complex networks (2017)

There is recent evidence that the XY spin model on complex networks can display three different macroscopic states in response to the topology of the network underpinning the interactions of the spins. In this work we present a way to characterize the macroscopic states of the XY spin model based on the spectral decomposition of time series using topological information about the underlying networks. We use three different classes of networks to generate time series of the spins for the three possible macroscopic states. We then use the temporal Graph Signal Transform technique to decompose the time series of the spins on the eigenbasis of the Laplacian. From this decomposition, we produce spatial power spectra, which summarize the activation of structural modes by the nonlinear dynamics, and thus coherent patterns of activity of the spins. These signatures of the macroscopic states are independent of the underlying network class and can thus be used as robust signatures for the macroscopic states. This work opens avenues to analyze and characterize dynamics on complex networks using temporal Graph Signal Analysis.
The Reduction of Optically Active 2-Nitroöctane and α-Phenylnitroethane1,2 (1955)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Reduction of Optically Active 2-Nitroöctane and α-Phenylnitroethane1,2Nathan Kornblum and Leon FishbeinCite this: J. Am. Chem. Soc. 1955, 77, 23, 6266–6269Publication Date (Print):December 1, 1955Publication History Published online1 May 2002Published inissue 1 December 1955https://pubs.acs.org/doi/10.1021/ja01628a063https://doi.org/10.1021/ja01628a063research-articleACS PublicationsRequest reuse permissionsArticle Views205Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
DETERMINATION O Ftrans-RESVERATROL IN SOME ROMANIAN WINES AND SPIRITS (2004)

Resveratrol, a phytoalexin of the hydroxystilbene group, is widely beneficial to health. It has been shown to possess anti-oxidative, anti-carcinogenic, anti-tumor, and anti-viral properties. The concentration of transresveratrol in some Romanian wines and spirits has been measured using a direct injection isocratic UV-HPLC (Ultra Violet - High Liquid Pressure Chromatography) method. The experimental values obtained ranged from 0,10 mg/L for Cognac Murfatlar to 2,32 mg/L for Carbent Sauvignon from the Dealu Mare region.
Near real-time plaque segmentation of IVUS (2003)

This article is devoted to the creation of a near-real time framework to discriminate between tissue and blood. We perform a fast supervised learning of local texture patterns of the plaque using local binary patterns. A classifier is built by assembling weak classifiers using boosting schemes that allow quick performance and reliability. After that, a deformable model is used to ensure continuity in the segmentation and to fill in the gaps in the classification scheme. Our supervised learning framework has been validated using 450 test images from 15 different patients. The resulting segmentation differs from the physicians segmentation in a mean rate of 0.15 mm. and maximum rate of 0.33 mm. The method benefits from the low time consuming feature extraction, as well as a faster classification scheme reducing 10 times the whole processing time compared to most of the texture based approaches.
Parallel excitation with an array of transmit coils (2004)

Theoretical and experimental results are presented that establish the value of parallel excitation with a transmit coil array in accelerating excitation and managing RF power deposition. While a 2D or 3D excitation pulse can be used to induce a multidimensional transverse magnetization pattern for a variety of applications (e.g., a 2D localized pattern for accelerating spatial encoding during signal acquisition), it often involves the use of prolonged RF and gradient pulses. Given a parallel system that is composed of multiple transmit coils with corresponding RF pulse synthesizers and amplifiers, the results suggest that by exploiting the localization characteristics of the coils, an orchestrated play of shorter RF pulses can achieve desired excitation profiles faster without adding strains to gradients. A closed-form design for accelerated multidimensional excitations is described for the small-tip-angle regime, and its suppression of interfering aliasing lobes from coarse excitation k-space sampling is interpreted based on an analogy to sensitivity encoding (SENSE). With or without acceleration, the results also suggest that by taking advantage of the extra degrees of freedom inherent in a parallel system, parallel excitation provides better management of RF power deposition while facilitating the faithful production of desired excitation profiles. Sample accelerated and specific absorption rate (SAR)-reduced excitation pulses were designed in this study, and evaluated in experiments.
Phase II Allowances Allocations and an Assessment of the Allowance Market in the West (1993)

Title IV of the Clean Air Act Amendments of 1990 establishes a unique “market-based“ approach to reduce national electric utility sulfur dioxide (SO2) emissions during the next century by about 10 million tons/year below the corresponding level in 1980. This program is designed to provide utility operators with the flexibility to achieve the applicable SO2 emissions limitations (total tons) using the most cost-effective approach. However, in reality, it is unlikely that many utility operators would have such operational flexibility, especially in the case of plants located in the Western United States. This is due to the fact that these sources may also be subject to other more stringent provisions of the Act, such as to protect public health and visibility, which override the Title IV provisions. This paper examines the Phase II allowance allocations for the utility units located in the 11 western states and assesses the potential impacts of the current federal/state air quality regulatory programs on the allowance market in the West. This analysis shows that, even after accounting for the projected population growth and the accompanying growth in electric power demand during the next decade, the West should have a surplus of allowances, especially if new regulations are initiated to further reduce SO2 emissions, mainly for the purpose of improving visibility in Western Class I areas.
Detection of Silent Myocardial Ischemia in Asymptomatic Diabetic Subjects (2004)

Silent myocardial ischemia occurs in greater than one in five asymptomatic patients with type 2 diabetes. Traditional and emerging cardiac risk factors were not associated with abnormal stress tests, although cardiac autonomic dysfunction was a strong predictor of ischemia.
Electroactive Organic Molecules Immobilized onto Solid Nanoparticles as a Cathode Material for Lithium‐Ion Batteries (2010)

Active monomers: Grafting soluble organic molecules onto insoluble, high-surface-area substrates, e.g. calixquinones on nanoparticles (see pciture), allows the production of a wide range of very stable materials for lithium-ion battery applications. Immobilization of the organic molecules avoids the problem of dissolution, which has previously led to performance degradation.
Notes on Solution of Problems in Odd Job Vapor Coating (1954)

Charts are presented for the solution of the problems pertaining to vapor coating in general. These charts are intended to be adequate to explain and describe the conditions necessary to produce high-quality metal coatings of given optical transmission and given electrical resistance as well as given thicknesses or given weight per unit area.
Multi-Dimensional Mapping of Design Imprecision (1996)

Abstract Preliminary design information is characteristically imprecise or fuzzy: specifications and requirements are subject to change, and the design description is vague and incomplete. The Method of Imprecision uses the mathematics of fuzzy sets to explicitly represent and manipulate imprecise preliminary design information, enabling the designer to better understand the full range of designs and performances that satisfy an imprecise set of specifications and requirements. This paper discusses the foundations of this methodology, and introduces pragmatic extensions that provide computationally tractable methods to map design imprecision from multiple design variables onto multiple performance variables. These methods attempt to minimize the number of function evaluations required while retaining an appropriate level of accuracy. This is achieved by using optimization to obtain extremal points for each performance variable and selectively applying a linear approximation for the mapping from the design variable space (DVS) to the performance variable space (PVS) to interpolate between extremal points. This linear approximation is constructed using regression techniques adapted from experiment design.
Studies on Assays for Plasma Prekallikrein and for the Monitoring of Coumarol Therapy (1978)

Chromogenic substrates were used to assay prekallikrein, prothrombin and factor X. Plasma prekallikrein was contact activated and allowed the splitting of HD-Pro-Phe-Arg-PNA which has affinity for plasma kallikrein. Prothrombin was assayed in various ways (immunologically, after activation with Ecarin or in a less specific way). Determination of factor X is considered as a possible specific method in the monitoring of coumarol therapy.
Computing the optical near-field distributions around complex subwavelength surface structures: A comparative study of different methods (1996)

Some 15 years ago, optical topographic signals with subwavelength resolution were obtained independently by several experimental teams. Since this exploratory period, a growing number of experimental configurations have been proposed and continuously developed. Simultaneously, this research field was supported by different theoretical works, aimed at developing our understanding of the interaction of optical fields with mesoscopic objects. Over the past three years, several theoretical frameworks have been proposed (Green's functions, field susceptibility, boundary conditions methods, multiple multipoles expansions, etc.). In this paper, an attempt at a careful comparison between two classes of numerical models is presented. Using the same test object, we discuss and compare the numerical solutions issued from a reciprocal-space perturbative method (Rayleigh approximation) and the solution originating from a direct-space integral approach (Green's function or field susceptibility). The discussion is given for different values of the relevant experimental parameters. The convergence of both approaches is investigated. \textcopyright{} 1996 The American Physical Society.
Pathophysiological considerations of seizures, epilepsy, and status epilepticus in the elderly. (2011)

Acute seizures, epilepsy and status epilepticus have the highest incidences in those over the age of 60 as compared to all other age groups. The most common etiological factors for epilepsy in the elderly are related to cerebrovascular disease. Diagnosing epilepsy in the elderly is challenging because of the subtle manifestations of partial seizures and the presence of age related cognitive difficulties, co-morbid conditions, and medications. Epilepsy treatment in this population is also difficult due to age related changes in pharmacokinetics and pharmacodynamics as well as individual variability. There are considerable gaps of knowledge about the basic pathophysiological mechanisms of recurrent partial onset seizures in the aged brain. This article critically reviews pathophysiological considerations that might impact the scientific approach of experimental research modeling of unprovoked seizures and epilepsy in elderly individuals, and the limited experimental epilepsy research on aged models.
Gene gravity-like algorithm for disease gene prediction based on phenotype-specific network (2017)

The good performance of phenotype-specific networks indicates that phenotype similarity information has positive effect on the prediction of disease genes. The proposed gene gravity-like algorithm outperforms the algorithm of Random Walk with Restart (RWR), implicating its predicting capacity by combing topological similarity with functional similarity. Our work will give an insight to the discovery of disease genes by fusing multiple similarities of genes and diseases.
Review of Fibre Sensor Techniques for Temperature-Strain Discrimination (1997)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text J. D. C. Jones, "Review of Fibre Sensor Techniques for Temperature-Strain Discrimination," in 12th International Conference on Optical Fiber Sensors, Vol. 16 of 1997 OSA Technical Digest Series (Optical Society of America, 1997), paper OTuC1. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article