gebhart/patrepeval huggingface dataset:
Management of acute ischaemic stroke in patients with dementia (2017)

An estimated 10% of stroke patients have an underlying dementia. As a consequence, health professionals often face the challenge of managing patients with dementia presenting with an acute stroke. Patients with dementia are less likely to receive thrombolysis (0.56-10% vs. 1-16% thrombolysis rates in the general population), be admitted to a stroke unit or receive some types of care. Anticoagulation for secondary stroke prevention is sometimes withheld, despite dementia not being listed as an exclusion criterion in current guidelines. Studies in this population are scarce, and results have been contradictory. Three observational studies have examined intravenous thrombolysis for treatment of acute ischaemic stroke in patients with dementia. In the two largest matched case-control studies, there were no significant differences between patients with and without dementia in the risks of intracerebral haemorrhage or mortality. The risk of intracerebral haemorrhage ranged between 14% and 19% for patients with dementia. Studies of other interventions for stroke are lacking for this population. Patients with dementia are less likely to be discharged home compared with controls (19% vs. 41%) and more likely to be disabled (64% vs. 59%) or die during hospitalization (22% vs. 11%). The aim of this review was to summarize current knowledge about the management of ischaemic stroke in patients with pre-existing dementia, including organizational aspects of stroke care, intravenous thrombolysis, access to stroke unit care and use of supportive treatment. Evidence to support anticoagulation for secondary prevention of stroke in patients with atrial fibrillation and antiplatelet therapy in nonembolic stroke will be discussed, as well as rehabilitation and how these factors influence patient outcomes. Finally, ethical issues, knowledge gaps and pathways for future research will be considered.
Grid-Supporting Inverters With Improved Dynamics (2018)

A new inverter control approach, called enhanced virtual synchronous machine (eVSM), is proposed based on the VSM concept. Unlike existing VSM approaches, the eVSM does not emulate the rotating inertia based on an assumption of the unlimited energy storage, but it deploys the physically existing inertia of the dc-link element. The eVSM adopts an innovative way of enlarging the inertia utilization range, which obviates the need for having a large dc-link element or a dedicated battery storage system, while still providing the same inertia response of an equivalent synchronous machine. Theoretical developments and numerical results presented in this paper confirm that the proposed eVSM can present a stabilizing support to the grid similar to a synchronous machine despite the small size of its dc-link element. Moreover, its transient responses can be improved beyond those of conventional synchronous machines thanks to the possibility of more flexibly adjusting damping and governor functions.
Quantitative analysis of the cytokine-mediated apoptosis-survival cell decision process (2005)

Thesis (Ph. D.)--Massachusetts Institute of Technology, Biological Engineering Division, 2005.
Canonical Saliency Maps: Decoding Deep Face Models (2021)

As Deep Neural Network models for face processing tasks approach human-like performance, their deployment in critical applications such as law enforcement and access control has seen an upswing, where any failure may have far-reaching consequences. We need methods to build trust in deployed systems by making their working as transparent as possible. Existing visualization algorithms are designed for object recognition and do not give insightful results when applied‘ to the face domain. In this work, we present ‘Canonical Saliency Maps’, a new method which highlights relevant facial areas by projecting saliency maps onto a canonical face model. We present two kinds of Canonical Saliency Maps: image-level maps and model-level maps. Image-level maps highlight facial features responsible for the decision made by a deep face model on a given image, thus helping to understand how a DNN made a prediction on the image. Model-level maps provide an understanding of what the entire DNN model focuses on in each task, and thus can be used to detect biases in the model. Our qualitative and quantitative results show the usefulness of the proposed canonical saliency maps, which can be used on any deep face model regardless of the architecture.
The helix filter: a new vena caval filter for the prevention of pulmonary embolism. (1985)

The helix caval filter is a continuous band spiral composed of a highly elastic metal alloy. A vertical double-helix coil fixes the filter in the infrarenal vena cava by elastic expansion while a watch spring type horizontal coil works as the filtering element. The diameter of the filter can be reduced by torsion from 32 to 7 mm. Transvenous implantation was performed under fluoroscopy using a newly developed instrument featuring intraoperative angiographic control, high flexibility, a guidance system, and a well-controlled release mechanism. The filter and the implantation technique were tested in a circulation system and in 10 dogs and 4 calves (follow-up 3-91 days). In addition, two filters were released intentionally into the right atrium of a dog and a calf. Flow resistance of the filter is negligible up to more than 10 1/min. Thrombi larger than 3.5 mm were filtered out reliably. Lethal complications, filter migrations or perforations did not occur in animal experiments. Filter coils which are in contact with the vessel wall become firmly incorporated within 3 to 4 weeks. The patency rate of the vena cava was 80% (8/10) for dogs and 100% (4/4) for calves. Implantations in the right atrium did not cause any symptoms. The filter's design allows fixation without hooks or spikes and consequently makes transvenous extraction possible up to 7-10 days after implantation. Comparable clinical results could extend the indications for caval filter implantation, and the decision which is still difficult today could be made easier.
Demonstration of 184 and 255-GHz Amplifiers Using InP HBT Technology (2008)

In this letter, 184 and 255 GHz single-stage heterojunction bipolar transistor (HBT) amplifiers are reported. Each amplifier uses a single-emitter 0.4 ¿m 15 ¿m InP HBT device with maximum frequency of oscillation (f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">max</sub> ) greater than 500 GHz and of 200 GHz. The 183 GHz single-stage amplifier has demonstrated gain of 4.3 ± 0.4 dB for all sites on the wafer. The 255 GHz amplifier has measured gain of 3.5d B and demonstrates the highest frequency measured HBT amplifier gain reported to date. Both amplifiers show excellent agreement with original simulation.
Optically tunable nuclear magnetic resonance in a single quantum dot (2010)

We report optically detected nuclear magnetic resonance (ODNMR) measurements on small ensembles of nuclear spins in single GaAs quantum dots. Using ODNMR we make direct measurements of the inhomogeneous Knight field from a photoexcited electron which acts on the nuclei in the dot. The resulting shifts of the NMR peak can be optically controlled by varying the electron occupancy and its spin orientation, and lead to strongly asymmetric line shapes at high optical excitation. The all-optical control of the NMR line shape will enable position-selective control of small groups of nuclear spins inside a dot.
Low-load rotor-synchronised Hahn-echo pulse train (RS-HEPT)1H decoupling in solid-state NMR: factors affecting MAS spin-echo dephasing times (2007)

Transverse dephasing times T(2)' in spin-echo MAS NMR using rotor-synchronised Hahn-echo pulse-train (RS-HEPT) low-load (1)H decoupling are evaluated. Experiments were performed at 300 and 600 MHz for (13)CH-labelled L-alanine and (15)NH(delta)-labelled L-histidine.HCl.H(2)O, together with SPINEVOLUTION simulations for a ten-spin system representing the crystal structure environment of the (13)CH carbon in L-alanine. For 30 kHz MAS and nu(1)((1)H) = 100 kHz at 300 MHz, a RS-HEPT T(2)' value of 17 +/- 1 ms was obtained for (13)CH-labelled L-alanine which is approximately 50% of the XiX T(2)' value of 33 +/- 2 ms. Optimum RS-HEPT decoupling performance is observed for a relative phase of alternate RS-HEPT pi-pulses, Deltaphi = phi'- phi, between 40 and 60 degrees . For experiments at 600 MHz and 30 kHz MAS with (13)CH-labelled L-alanine, the best RS-HEPT (nu(1)((1)H) = 100 kHz) T(2)' value was 3 times longer than that observed for low-power continuously applied sequences with nu(1)((1)H) < or =40 kHz, i.e. corresponding to the same average power dissipated in the probe. A marked improvement in RS-HEPT (1)H decoupling is observed for increasing MAS frequency: at 55.6 kHz MAS, a best RS-HEPT T(2)' value of 34 +/- 5 ms was recorded for (13)CH-labelled L-alanine. Much improved RS-HEPT broadband performance was also observed at 55.6 kHz MAS as compared to 30 kHz MAS.
On the Two-View Geometry of Unsynchronized Cameras (2017)

We present new methods of simultaneously estimating camera geometry and time shift from video sequences from multiple unsynchronized cameras. Algorithms for simultaneous computation of a fundamental matrix or a homography with unknown time shift between images are developed. Our methods use minimal correspondence sets (eight for fundamental matrix and four and a half for homography) and therefore are suitable for robust estimation using RANSAC. Furthermore, we present an iterative algorithm that extends the applicability on sequences which are significantly unsynchronized, finding the correct time shift up to several seconds. We evaluated the methods on synthetic and wide range of real world datasets and the results show a broad applicability to the problem of camera synchronization.
Watermarking for self-authentication of compressed video (2003)

This paper reports on watermarking of MPEG video for authentication and tamper detection. The algorithm operates entirely on the compressed bitstream and maintains MPEG-2 syntax throughout. In the proposed algorithm, I-frames watermark the entire length of the following GOP. The algorithm first computes the payload capacity of each GOP by identifying the population of eligible VLCs capable of carrying the watermarks. The candidate I-frame is then compressed to this target bit rate and the bits are reordered based on a GOP-unique key. The scrambled bits then sequentially watermark the GOP. Detection follows an inverse process. Watermarked video is resistant to tampering at the GOP level by observing the key sequencing needed for watermark extraction. Missing GOPs cause jumps in the required keys which can then be connected to the number of affected GOPs. Corruption or frame-level tampering inside a GOP can also be spotted using a similar approach.
Phosphatidylinositol (3,4,5)-trisphosphate specifically interacts with the phox homology domain of phospholipase D1 and stimulates its activity (2005)

Phospholipase D (PLD), which catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline, plays key roles in cellular signal transduction by mediating extracellular stimuli including hormones, growth factors, neurotransmitters, cytokines and extracellular matrix molecules. The molecular mechanisms by which domains regulate the activity of PLD--especially the phox homology (PX) domain--have not been fully elucidated. In this study, we have examined the properties of the PX domains of PLD1 and PLD2 in terms of phosphoinositide binding and PLD activity regulation. Interestingly, the PX domain of PLD1, but not that of PLD2, was found to specifically interact with phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P3). We found that mutation of the conserved arginine at position 179 of the PLD1 PX domain to lysine or to alanine (R179A or R179K, respectively) disrupts PtdIns(3,4,5)P3 binding. In NIH-3T3 cells, the EGFP-PLD1 PX wild-type domain, but not the two mutants, localized to the plasma membrane after 5-minute treatment with platelet-derived growth factor (PDGF). The enzymatic activity of PLD1 was stimulated by adding PtdIns(3,4,5)P3 in vitro. Treatment with PDGF resulted in the significant increase of PLD1 activity and phosphorylation of the downstream extracellular signal-regulated kinases (ERKs), which was blocked by pre-treatment of HEK 293 cells with phosphoinositide 3-kinase (PI3K) inhibitor after the endogenous PLD2 had been depleted by siRNA specific for PLD2. Nevertheless, both PLD1 mutants (which cannot interact with PtdIns(3,4,5)P3) did not respond to treatment with PDGF. Moreover, PLD1 was activated in HepG2 cells stably expressing the Y40/51 mutant of PDGF receptor that is required for the binding with PI3K. Our results suggest that the PLD1 PX domain enables PLD1 to mediate signal transduction via ERK1/2 by providing a direct binding site for PtdIns(3,4,5)P3 and by activating PLD1.
Technique of dissecting the internal mammary after using the moussalli bar (1990)

Since 1985 we have utilised a simple technique for dissecting the internal mammary artery (IMA) prior to coronary artery bypass surgery. The technique involves the use of a stainless steel bar (Moussalli bar) in conjunction with a Holmes Sellors sternal spreader. We have used this technique to dissect more than 2000 IMAs in patients of varying body weight and muscle build without significant complications.
Soot and other Products Formation from the Submerged Carbon Arc in Halogenated Solvents (2005)

Abstract A series of selected halomethanes were treated with the submerged carbon arc using graphite electrodes at 10A. CCl4 and CHCl3 produce abundant soot which is double in comparison to the soot produced by arcing CH2Cl2 and is one order of magnitude higher than the amount of soot produced by arcing hydrocarbons such as n‐hexane or decalin and two orders of magnitudes higher in comparison to the amounts of soot produced by arcing alcohols. It was found a anticorrelation between the amount of polyynes present in the solution of the arced solvent and the amount of soot produced by arcing. In the case of CCl4 and CHCl3 no polyynes were detected by liquid chromatographic analysis (HPLC‐DAD), while polyynes were detected in CH2Cl2 and are present in higher concentration in arced hydrocarbon solutions. The soot produced from halomethanes was analyzed by FT‐IR spectroscopy in comparison to the soot produced by arcing hydrocarbons and alcohols. Furthermore, the soot from halomethanes was analyzed by HPLC‐DAD ...
Crystal Growth, Transport, and Magnetic Properties of YbCoGa5 (2009)

Single crystals of YbCoGa5 have been synthesized using gallium flux. YbCoGa5 crystallizes in the HoCoGa5 structure type with space group P4/mmm (No. 123), Z = 1 and lattice parameters a = 4.190(1) Å, c = 6.727(3) Å, and V = 118.10(7) Å3. The cell volume obtained from single crystal X-ray diffraction data shows a larger volume than expected for a Yb3+ compound. Magnetic susceptibility measurements on single crystals of YbCoGa5 display temperature independent Pauli paramagnetic behavior. Electrical resistivity measurements of YbCoGa5 display metallic behavior with a residual resistivity ratio (RRR) of 150 indicating the high crystal quality.
Cu(II) Complexes with FomA Protein Fragments of Fusobacterium Nucleatum Increase Oxidative Stress and Malondialdehyde Level (2019)

An explanation of carcinogenesis processes may certainly contribute to the prevention and development of novel methods for cancer treatment. In this paper, we considered the probable relationship between the presence of <i>Fusobacterium nucleatum</i> in the colon and its possible influence on the development of colorectal cancer. For this purpose, intracellular and/or extracellular generation of reactive oxygen species (ROS) by mouse colon carcinoma cells (CT26) was stimulated by two fragments of FomA adhesin from <i>F. nucleatum</i> and their complexes with copper(II): Cu(II)-Ac-KGHGNG-NH<sub>2</sub> (<b>1Cu</b>) and Cu(II)-Ac-PTVHNE-NH<sub>2</sub> (<b>2Cu</b>). Incubation of the cells with copper complexes was followed with ICP-MS technique. The overall generation of ROS was shown by means of fluorescence spectroscopy with two proper probes, whereas identification of ROS was achieved by the spin trapping technique and electron paramagnetic resonance measurements. As a result, an abundant production of the hydroxyl radicals, both inside and outside the cells, was observed upon the stimulation of the CT26 cells with the copper complexes. Clearly both compounds induced strong oxidation stress which triggered a radicals' cascade that finally resulted in the pronounced lipid peroxidation. The latter was evidenced with the measured level of malondialdehyde, a biomarker of the peroxidation process. By applying <i>N</i>-acetylcysteine antioxidant to the studied system, the free radical mechanism of the lipid peroxidation process was confirmed. Hypothetically this mechanism can lead to colon cell damage and further cancerogenesis processes.
ChemInform Abstract: 9‐THIABICYCLO(4,2,1)NONATRIEN‐(2,4,7)‐DIOXID‐(9,9) (1972)

Abstract Cyclooctatetraen (I) reagiert mit l Äquivalent (Äq.) SbF 5 in flüssigem SO 2 über den zunächst gebildeten Komplex (II) nach Aufarbeitung mit Dichlormethan/Wasser zum Sulfon (III), aus dem bei Behandlung mit 1 Äq. SbF 5 /SO 2 wieder der Komplex (II) erhalten wird.
New directions for integrated circuit cards operating systems (1995)

Integrated circuit cards or smart cards are now well-known. Applications such as electronic purses (cash units stored in cards), subscriber identification cards used in cellular telephone or access keys for pay-TV and information highways emerge in many places with millions of users. More services are required by applications providers and card holders. Mainly, new integrated circuit cards evolve towards non-predefined multi-purpose, open and multi-user applications. Today, operating systems implemented into integrated circuit cards cannot respond to these new trends. They have evolved from simple operating systems defining an hardware abstraction level up to file management systems or database management systems where the card behavior was defined once at the manufacturing level or by the card issuer. The needs for open and flexible card life cycle enabling to accommodate executable code loaded by different service providers require a new generation of smart cards. Operating systems based on object-oriented technologies are key components for future integrated circuit cards applications.
Allele and locus‐specific differences in cell surface expression and the association of HLA class I heavy chain with β2‐microglobulin: differential effects of inhibition of glycosylation on class I subunit association (1988)

The assembly of HLA class I antigens, and the contribution of the single N-linked glycan to this process were examined. We observed a requirement for N-linked glycosylation in the proper assembly and surface expression of HLA-B locus products in particular, although considerable variation was seen within the allelic series of the HLA-A and B loci. We conclude that the single N-linked glycan can contribute in a major way to that conformation of the heavy (H) chain which is competent to associate with the light chain beta 2-microglobulin, and that the presence, rather than the type, of carbohydrate chain is important in this respect. The association of human class I H chains with beta 2-microglobulin shows biphasic kinetics, where an initially rapid phase is followed by a prolonged period during which no further association can be measured. It appears that HLA-C H chains are initially synthesized in amounts similar to HLA-A and B H chains, but associate inefficiently with beta 2-microglobulin, resulting in low expression of HLA-C at the cell surface. The individual stages of assembly and maturation of class I antigens including the transfer from Golgi to cell surface were found to display characteristic allelic variation.
Novel, Very Strong, Uncharged Auxiliary Bases; Design and Synthesis of Monomeric and Polymer‐Bound Triaminoiminophosphorane Bases of Broadly Varied Steric Demand (1994)

The synthesis and properties of a number of very strong iminophosphorane bases up to an extremely high level of steric hindrance are described. They cover a range of ca. 4 p K units in basicity and a range of more than 11 orders of magnitude in their rates of methylation with methyl iodide. Most of the systems are readily prepared in up to molar quantities, conveniently recovered from their salts and are of high chemical and thermal stability. Crystal structures were determined in order to parametrize a force field, which is utilized in molecular modeling studies offering a rationalization of the observed differences in steric hindrance and basicity. Depending on the degree of steric protection of the basic center, these novel bases are proposed as unprecedented, versatile auxiliary bases in E2 eliminations and in reactions involving deprotonation in the presence of more or less strong electrophiles.
Large-scale commercial applications of the in situ vitrification remediation technology (1994)

The first large-scale commercial application of the innovative In Situ Vitrification (ISV) remediation technology was completed at the Parsons Chemical/ETM Enterprises Superfund site in Michigan State midyear 1994. This project involved treating 4,800 tons of pesticide and mercury-contaminated soil. The project also involved performance of the USEPA SITE Program demonstration test for the ISV technology. The Parsons project involved consolidation and staging of contaminated soil from widespread locations on and nearby the site. This paper presents a brief description of the ISV technology along with case-study type information on these two sites and the performance of the ISV technology on them. The paper also reviews other remediation projects where ISV has been identified as the/a preferred remedy, and where ISV is currently planned for use. These sites include soils contaminated with pesticides, dioxin, PCP, paint wastes, and a variety of heavy metals. This review of additional sites also includes a description of a planned radioactive mixed waste remediation project in Australia that contains large amounts of plutonium, uranium, lead, beryllium, and metallic and other debris buried in limestone and dolomitic soil burial pits. Initial test work has been completed on this application, and preparations are now underway for pilot testingmore » in Australia. This project will demonstrate the applicability of the ISV technology to the challenging application of buried mixed wastes.« less
Racematspaltung von 1,2-Dibromhexafluorpropan über Halogen-verbrückte supramolekulare Helices (1999)

Halogenbrücken, anziehende intermolekulare Wechselwirkungen zwischen Perfluoralkylbromiden und Bromidionen, liegen in Mischkristallen aus (−)-Sparteinhydrobromid 1 und (S)-1,2-Dibromhexafluorpropan 2 vor (schematisch dargestellt) und führen zur Bildung enantiomerenreiner, endloser supramolekularer Helices. Die Aggregatbildung durch Selbstorganisation von Perfluorkohlenwasserstoff und Kohlenwasserstoff ermöglicht die Racematspaltung von 2.
Simple Synthesis of P(Cbz‐alt‐TBT) and PCDTBT by Combining Direct Arylation with Suzuki Polycondensation of Heteroaryl Chlorides (2014)

Direct arylation (DA) of 2-chlorothiophene and 2-chloro-3-hexylthiophene with 4,7-dibromo-2,1,3-benzothiadiazole is used to synthesize 4,7-bis(5-chloro-2-thienyl)-2,1,3-benzothiadiazole (TBTCl2) and 4,7-bis(5-chloro-4-hexyl-2-thienyl)-2,1,3-benzothiadiazole (DH-TBTCl2) in one step. Suitable conditions of the Suzuki polycondensations (SPC) of TBTCl2 and DH-TBTCl2 with the carbazole comonomer CbzPBE2 are established, furnishing PCDTBT and P(Cbz-alt-TBT) with high molecular weight and yield. Compared with control samples made from the corresponding dibromides, high-temperature NMR and UV-vis spectroscopy indicate similar properties for PCDTBT but an increased content of Cbz-Cbz homocouplings for P(Cbz-alt-TBT).