gebhart/patrepeval huggingface dataset:
Damage to the default mode network disrupts autobiographical memory retrieval (2014)

Functional neuroimaging studies have implicated the default mode network (DMN) in autobiographical memory (AM). Convergent evidence from a lesion approach would help clarify the role of the DMN in AM. In this study, we used a voxelwise lesion-deficit approach to test the hypothesis that regions of the DMN are necessary for AM. We also explored whether the neural correlates of semantic AM (SAM) and episodic AM (EAM) were overlapping or distinct. Using the Iowa Autobiographical Memory Questionnaire, we tested AM retrieval in 92 patients with focal, stable brain lesions. In support of our hypothesis, damage to regions within the DMN (medial prefrontal cortex, mPFC; posterior cingulate cortex, PCC; inferior parietal lobule, IPL; medial temporal lobe, MTL) was associated with AM impairments. Within areas of effective lesion coverage, the neural correlates of SAM and EAM were largely distinct, with limited areas of overlap in right IPL. Whereas SAM deficits were associated with left mPFC and MTL damage, EAM deficits were associated with right mPFC and MTL damage. These results provide novel neuropsychological evidence for the necessary role of parts of the DMN in AM. More broadly, the findings shed new light on how the DMN participates in self-referential processing.
Bootstrapping a spoken language identification system using unsupervised integrated sensing and processing decision trees (2011)

In many inference and learning tasks, collecting large amounts of labeled training data is time consuming and expensive, and oftentimes impractical. Thus, being able to efficiently use small amounts of labeled data with an abundance of unlabeled data-the topic of semi-supervised learning (SSL) [1]-has garnered much attention. In this paper, we look at the problem of choosing these small amounts of labeled data, the first step in a bootstrapping paradigm. Contrary to traditional active learning where an initial trained model is employed to select the unlabeled data points which would be most informative if labeled, our selection has to be done in an unsupervised way, as we do not even have labeled data to train an initial model. We propose using unsupervised clustering algorithms, in particular integrated sensing and processing decision trees (ISPDTs) [2], to select small amounts of data to label and subsequently use in SSL (e.g. transductive SVMs). In a language identification task on the CallFriend1 and 2003 NIST Language Recognition Evaluation corpora [3], we demonstrate that the proposed method results in significantly improved performance over random selection of equivalently sized training data.
[Patient reporting of self-measurement results: survey Autoprov]. (2009)

Nowadays, the benefits and indications of blood pressure self-measurement are well-established and codified by clinical practice recommendations. However, in routine practice, one aspect is still unclear: the way patients report to their physician the results of the measurements taken at home. Few data are available in scientific publications in this respect and the recommended protocols are not adhered to in practice. In a practice survey, 4538 patients instructed to perform blood pressure self-measurement by their general practitioner were asked to report the results on a preprinted sheet and offered the possibility to use the website automesure.com to calculate their average and report the results to their physician. Most patients (81%) were able to provide on a preprinted sheet the results of six measurements per day (three in the morning and three in the evening) on a three-day period (18 measurements in total), and 40% followed the recommendation to use Internet to calculate the average. However, only 12% of patients approximately, significantly younger, were able to use a dedicated application program. As for physicians, they were not ready overall to provide their email address to establish an interactive relationship with their patients.
A Vibro-Haptic Human-Machine Interface for Structural Health Monitoring Applications (2013)

Over the last 10 years, the Structural Health Monitoring (SHM) field has struggled to replace human-based inspections of structures with autonomous sensor networks and classification algorithms. The goal of the SHM community has been to endow structures with an artificial nervous system similar to that of living organisms. This paper proposes a new paradigm which leverages the human nervous system in concert with distributed sensor networks and computational resources. We propose using emerging haptic technology to create a harmonious collaboration between humans, SHM sensor networks, and statistical classification. The neuroscience community has demonstrated haptic-based methods for replacing lost sensations. However, this project explores the possibility of giving humans a new sense – one which reflects the health of a structure. The generation of this sense is achieved through a vibro-haptic human-machine interface. The testbed is composed of a surrogate three-story structure which can be modified to exhibit non-linear dynamic responses on any combination of its three floors. With the use of a vibro-haptic interface, we will study the ability of human users to determine the characteristics of non-linear response. Establishing this intimate connection between humans and structures is the first step in creating a new SHM paradigm that combines human intelligence with distributed measurement capabilities.
Analytic mean and variance of forward propagated field through random internal waves and subbottom anomalies with Rayleigh–Born scattering (2004)

The mean and variance of the field propagated through a waveguide containing random internal waves or subbottom anomalies is modeled using a modal solution [Ratilal and Makris, J. Acoust. Soc. Am. 114, 2428 (2003)] that analytically expresses the effects of dispersion, attenuation, and redistribution of modal energy due to multiple scattering in the forward direction. The scatter function of an elemental volume of inhomogeneity in density and compressibility is modeled using the Rayleigh–Born approximation. Simulations in both continental shelf and deep water waveguides quantitatively show how the relative magnitude of coherent versus incoherent intensity varies with range in typical internal wave fields and subbottom environments.
Hot carrier self convergent programming method for multi-level flash cell memory (2002)

Flash EEPROM multi-level programming requires accurate control of programmed threshold voltages. A hot carrier convergent programming method with drain current monitoring is proposed to reduce both Vth dispersion and write-erase window closure during endurance test. Feasibility and improved reliability is demonstrated for a four level storage on 0.35 /spl mu/m flash cells.
Patterns of relative magnitudes of soil energy channels and their relationships with environmental factors in different ecosystems in Romania (2015)

The percentage compositions of soil herbivorous, bacterivorous and fungivorous nematodes in forests, grasslands and scrubs in Romania was analysed. Percentages of nematode abundance, biomass and metabolic footprint methods were used to evaluate the patterns and relative size of herbivory, bacterial- and fungal-mediated channels in organic and mineral soil horizons. Patterns and magnitudes of herbivore, bacterivore and fungivore energy pathways differed for a given ecosystem type and soil depth according to the method used. The relevance of herbivore energy channel increased with soil depth due to higher contribution of root-feeders. Ectoparasites, sedentary parasites and epidermal cell and root hair feeders were the most important contributors to the total biomass and metabolic footprints of herbivores. Metabolic footprint method revealed the general dominance of bacterial-based energy channel in all five types of ecosystems. The influence of altitude and climatic factors on percentages of abundance, biomass and metabolic footprints of herbivores, bacterivores and fungivores decreased with soil depth, whereas the influence of humus content, cation-exchange capacity and base saturation increased. Vegetation, altitude, climate and soil physico-chemical characteristics are important factors that influenced the abundance, biomass and metabolic footprints of herbivores, bacterivores and fungivores.
Web Based Development And Delivery Of Course Material On Maintenance Engineering (2020)

The objective of this technology enhanced course material development is to create instructional objects that are suitable for both synchronous presentation and for use as webbased modules for students accessing the material anytime and anywhere. This project has been undertaken as part of the effort by the College of Engineering at The University of Tennessee for enhancing the delivery of instructional material. The development and demonstration of the web-based teaching material is focused on one of the modules used in the college-wide course entitled Introduction to Maintenance Engineering. The module incorporates interactive course material, examples, PowerPoint slides, and video clips of rotating machinery in operation.
The Evolution of Desaturase Gene Regulation Involved in Sex Pheromone Production in Leafroller Moths of the Genus Planotortrix (2013)

The evolution of mating systems in leafroller moths involves differential regulation of a desaturase gene that produces distinct sex pheromones.In the genus Planotortrix, female P. octo predominantly emits (Z)-8-tetradecenyl acetate due to the expression of desat5 in their pheromone glands, whereas female P. excessana produces a blend of (Z)-5-and (Z)-7-tetradecenyl acetate and does not express desat5.In this study, F 1 females from interspecific crosses of these species and F 1 backcrosses to P. excessana expressed little, if any, desat5 in their pheromone glands, whereas F 1 backcrosses to P. octo and F 2 crosses displayed a range of expression levels of desat5, consistent with the action of a trans-acting repressor from P. excessana.Females expressing desat5 always produced (Z)-8-tetradecenyl acetate, and the presence of at least one P. octo-like allele of desat5 was required for the expression of desat5, suggesting a cis-regulatory factor from P. octo is necessary.Comparison of 1148 bp upstream of the desat5 open reading frame revealed 35 differences, including a 7-bp insertion in P. octo.We argue these data best fit a model of pheromone evolution that involves changes in a trans-acting repressor and a cis-regulatory mutation in an activator binding site within the desat5 promoter.
The use of Portable Intraoperative Computed Tomography Scanning for Real-Time Image Guidance: A Pilot Cadaver Study (2008)

Intraoperative portable CT scanning with real-time IGS updates is feasible and likely would add little additional time. Accuracy is improved at the skull base. Prospective studies on actual patients are warranted.
A national survey of venous sinus stenting practices for idiopathic intracranial hypertension (2022)

This is the first study designed to understand the opinions and practices of neurointerventionists regarding VSS for IIH. Overall physician opinion on VSS was quite positive, supported by increasing procedural volumes reported by most over the past few years. However, only a small percentage of respondents had substantial experience with VSS and major complications were not rare.
Reliability and Validity of an Instrument of COVID-19 Patient-Reported Symptoms in Outpatients (2022)

This study identified 19 items that are valid and reliable to measure disease-related symptoms in outpatients with COVID-19, and proposed a definition of symptom resolution for potential use in future clinical trials.
Naissance d'un national-confucianisme ? (1995)

Beja Jean-Philippe. Naissance d'un national-confucianisme ?. In: Perspectives chinoises, n°30, 1995. pp. 6-11.
Supplementary Table 1 from Comprehensive Molecular Profiling of Intrahepatic and Extrahepatic Cholangiocarcinomas: Potential Targets for Intervention (2023)

&lt;p&gt;Molecular predictors of progression free survival in patients treated with cytotoxic chemotherapy&lt;/p&gt;
A Polarity-Sensitive Far-Red Fluorescent Probe for Glucose Sensing through Skin (2023)

The field of glucose biosensors for diabetes management has been of great interest over the past 60 years. Continuous glucose monitoring (CGM) is important to continuously track the glucose level to provide better management of the disease. Concanavalin A (ConA) can reversibly bind to glucose and mannose molecules and form a glucose biosensor via competitive binding. Here, we developed a glucose biosensor using ConA and a fluorescent probe, which generated a fluorescent intensity change based on solvatochromism, the reversible change in the emission spectrum dependent on the polarity of the solvent. The direction in which the wavelength shifts as the solvent polarity increases can be defined as positive (red-shift), negative (blue-shift), or a combination of the two, referred to as reverse. To translate this biosensor to a subcutaneously implanted format, Cyanine 5.5 (Cy5.5)-labeled small mannose molecules were used, which allows for the far-red excitation wavelength range to increase the skin penetration depth of the light source and returned emission. Three Cy5.5-labeled small mannose molecules were synthesized and compared when used as the competing ligand in the competitive binding biosensor. We explored the polarity-sensitive nature of the competing ligands and examined the biosensor's glucose response. Cy5.5-mannotetraose performed best as a biosensor, allowing for the detection of glucose from 25 to 400 mg/dL. Thus, this assay is responsive to glucose within the physiologic range when its concentration is increased to levels needed for an implantable design. The biosensor response is not statistically different when placed under different skin pigmentations when comparing the percent increase in fluorescence intensity. This shows the ability of the biosensor to produce a repeatable signal across the physiologic range for subcutaneous glucose monitoring under various skin tones.
A Study on the Efficiency of ASTC Texture Format in Mobile Game Environment (2019)

본 연구는 모바일 Android OS에서 텍스쳐 포맷인 ASTC의 메모리 점유율, CPU 처리 속도, 평균 프레임 비교 검증을 진행하였다. 실험 환경 구성으로 가상의 게임 씬을 구현하여 Android 플랫폼으로 빌드하였다. 이를 바탕으로 비교 검증 데이터를 추출하였다. ASTC는 ETC보다 2D 텍스쳐의 메모리 사용량에서 36% 낮은 점유율을 보였다. CPU 연산 처리에서는 18% 빠른 처리속도를 보였다. 평균 프레임은 58% 더 높은 54프레임을 확인하였다. 스마트 모바일 게임 환경에서 ASTC는 ETC보다 비교우위의 결과를 확인하였다.
Crystal and molecular structure of N4-aminocytosine. (1980)

The crystal and molecular of N4-aminocytosine was determined by X-ray diffraction. This compound belongs to the monoclinic space group P21/a with four molecules in a unit cell of α=7.950 (2) Å ; b=11.156 (2) Å ; c=6.054 (3) Å ; β=94.59 (2)° ; V=535.2 (3) Å3. The final R value was 0.072 including hydrogen atoms. The present study established that this compound takes the C (4)-amino form rather than the imino form, and is consistent with the report (D. M. Brown, M. J. E. Hewlins and P. Schell, J. Chem. Soc. (C), 1968, 1925 that 1-methyl-N4-aminocytosine takes the amino form in solution.
A Hybrid Approach towards Assisting Ankle Joint of Paretic Patients (2016)

International audience
Paper-based nanobiosensors for diagnostics (2012)

In this review we discuss how nanomaterials can be integrated in diagnostic paper-based biosensors for the detection of proteins, nucleic acids and cells. In particular first the different types and properties of paper-based nanobiosensors and nanomaterials are briefly explained. Then several examples of their application in diagnostics of several biomarkers are reported. Finally our opinions regarding future trends in this field are discussed.
Premultiplication scheme for digital FIR filters with application to multirate filtering (1978)

The transposed direct form is discarded, in general, for implementation of digital FIR filters. However, it is shown to have the same flexibility as the usual straight direct form in serial processing. It leads to a premultiplication scheme well adapted to processing data sequences in serial binary representations with a single multiplexed multiplier, long shift-registers, and very simple control circuity. All these features are very desirable in large-scale integration (LSI) techniques. Particularly appealing applications to multiplexing and multirate filtering of various kinds are examined.
Convex treemaps with bounded aspect ratio (2011)

Treemaps are a popular technique to visualize hierarchical data. The input is a weighted tree T where the weight of each node is the sum of the weights of its children. A treemap for T is a hierarchical partition of a rectangle into simply connected regions, usually rectangles. Each region represents a node of T and the area of each region is proportional to the weight of the corresponding node. An important quality criterium for treemaps is the aspect ratio of its regions. Unfortunately, one cannot bound the aspect ratio if the regions are restricted to be rectangles. Hence Onak and Sidiropoulos introduced polygonal partitions, which use convex polygons. We are the first to obtain convex partitions with optimal aspect ratio O(depth(T )). We also consider the important special case that depth(T ) = 1, that is, single-level treemaps. We show how to construct convex single-level treemaps that use only four simple shapes for the regions and have aspect ratio at most 34/7.
Electrochemical and Corrosion Characterization of TiO2-RuO2/Ti Electrodes Modified with WO3 (2019)

DSA (dimensionally stable anodes)-type electrodes (TiO2-RuO2-WO3/Ti) were prepared by the thermal decomposition of proper metal precursor on titanium substrate. Electrochemical and corrosion characteristics of these electrodes were determined in [Fe(CN)6]3−/[Fe(CN)6]4− system and Na2SO4 solution with the application of cyclic voltammetry and chronoamperometry. The electrode active surface area and the activity towards oxygen evolution were evaluated. Moreover, corrosion resistance of the tested electrodes was estimated by determination of basic corrosion parameters. The introduction of WO3 into the oxide layer of the electrodes resulted in a decrease in electrode active surface area and in the number of active sites. The modified electrodes revealed lower activity towards OER but higher activity in organic oxidation. However, their stability was significantly higher in comparison with the non-modified electrode. Corrosion characteristics of the tested electrodes proved the highest corrosion resistance in the case of the electrode modified with 3% WO3. The modification of TiO2-RuO2/Ti with WO3 seems to be advantageous in the application in electrochemical and photoelectrochemical degradation of organic pollutants.
Artificial Intelligence-rationalized balanced PPARα/γ dual agonism resets the dysregulated macrophage processes in inflammatory bowel disease (2021)

ABSTRACT A computational platform, the Boolean network explorer ( BoNE ), has recently been developed to infuse AI-enhanced precision into drug discovery; it enables querying and navigating invariant Boolean Implication Networks of disease maps for prioritizing high-value targets. Here we used BoNE to query an Inflammatory Bowel Disease (IBD)-map and prioritize a therapeutic strategy that involves dual agonism of two nuclear receptors, PPARα/γ. Balanced agonism of PPARα/γ was predicted to modulate macrophage processes, ameliorate colitis in network-prioritized animal models, ‘reset’ the gene expression network from disease to health, and achieve a favorable therapeutic index that tracked other FDA-approved targets. Predictions were validated using a balanced and potent PPARα/γ-dual agonist (PAR5359) in two pre-clinical murine models, i.e., Citrobacter rodentium -induced infectious colitis and DSS-induced colitis. Using a combination of selective inhibitors and agonists, we show that balanced dual agonism promotes bacterial clearance more efficiently than individual agonists, both in vivo and in vitro . PPARa is required and its agonism is sufficient to induce the pro-inflammatory cytokines and cellular ROS, which are essential for bacterial clearance and immunity, whereas PPARg-agonism blunts these responses, delays microbial clearance and induces the anti-inflammatory cytokine, IL10; balanced dual agonism achieved controlled inflammation while protecting the gut barrier and ‘reversal’ of the transcriptomic network. Furthermore, dual agonism reversed the defective bacterial clearance observed in PBMCs derived from IBD patients. These findings not only deliver a macrophage modulator for use as barrier-protective therapy in IBD, but also highlight the potential of BoNE to rationalize combination therapy.
Effect of Fluoxetine and Acacetin on Central Vestibular Compensation in an Animal Model of Unilateral Peripheral Vestibulopathy (2022)

Damage to the peripheral vestibular system is known to generate a syndrome characterized by postural, locomotor, oculomotor, perceptual and cognitive deficits. Current pharmacological therapeutic solutions for these pathologies lack specificity and efficacy. Recently, we demonstrated that apamin, a specific SK channel blocker, significantly reduced posturo-locomotor and oculomotor deficits in the cat and the rat. The aim of the present study was to test the antivertigo potential of compounds belonging to the SK antagonists family, such as Acacetin and Fluoxetine. Young rats were subjected to unilateral ototoxic lesions of the vestibular organ using transtympanic administration of arsanilic acid (TTA) to evoke unilateral vestibular loss (UVL). Vestibular syndrome was monitored using behavioural evaluation allowing appreciation of the evolution of static and dynamic posturo-locomotor deficits. A significant effect of the TTA insult was only found on the distance moved, the mean body velocity and the not moving time. From day 2 to week 2 after TTA, the distance moved and the mean body velocity were significantly decreased, while the not moving time was significantly increased. Acacetin does not evoke any significant change in the vestibular posturo-locomotor parameters' kinetics. Administration of Fluoxetine two weeks before TTA and over three weeks after TTA (preventive group) does not evoke any significant change in the vestibular posturo-locomotor parameters' kinetics. Administration of Fluoxetine from three weeks after TTA significantly delayed the functional recovery. This study demonstrates that Acacetin or Fluoxetine in TTA vestibulo-injured rats does not bring any significant benefit on the posture and locomotor balance deficits.
Subtype-specific gout susceptibility loci and enrichment of selection pressure on ABCG2 and ALDH2 identified by subtype genome-wide meta-analyses of clinically defined gout patients (2020)

Our findings on subtype GWAS meta-analyses and selection pressure analysis of gout will assist elucidation of the subtype-dependent molecular targets and evolutionary involvement among genotype, phenotype and subtype-specific tailor-made medicine/prevention of gout and hyperuricaemia.
Fabrication of graded nickel-quasicrystal composite by electrodeposition (2002)

SUMMARYFunctionally graded coatings with a gradual change in composition and microstructure can perform specific functions and meet stringent performance requirements. A new graded composite coating, nickel-quasicrystal, was examined in this paper. It was found that the volume percentage of embedded quasicrystal particles in the composite increased with an increase in current density up to 10 A dm2. A maximum volume percentage quasicrystal particles of 48.2% was obtained at the current density of 10 A dm−2, an electrolyte particle content of 50 g dm3, agitation speed of 400 rpm, and particle size of 5 μm Graded Ni-quasicrystal composite coatings were produced by manipulating the current density and the deposition time, and their hardness and composition were evaluated.