gebhart/patrepeval huggingface dataset:
CCDC 856562: Experimental Crystal Structure Determination (2012)

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Synergistic Action of Atrial Dilation and Sodium Channel Blockade on Conduction in Rabbit Atria (2004)

In dilated atria, blockade of the rapid sodium channels caused a higher degree of local conduction delay and intra-atrial conduction block than in nondilated atria.
The Intracellular Virus-Containing Compartments in Primary Human Macrophages Are Largely Inaccessible to Antibodies and Small Molecules (2012)

HIV-1 assembly and release occurs at the plasma membrane of human T lymphocytes and model epithelial cell lines, whereas in macrophages intracellular sites of virus assembly or accumulation predominate. The origin of the intracellular virus-containing compartment (VCC) has been controversial. This compartment is enriched in markers of the multivesicular body, and has been described as a modified endosomal compartment. Several studies of this compartment have revealed the presence of small channels connecting to the plasma membrane, suggesting that instead of an endosomal origin the compartment is a modified plasma membrane compartment. If the compartment is accessible to the external environment, this would have important implications for antiviral immune responses and antiviral therapy. We performed a series of experiments designed to determine if the VCC in macrophages was open to the external environment and accessible to antibodies and small molecules. The majority of VCCs were found to be inaccessible to exogenously-applied antibodies to tetraspanins in the absence of membrane permeabilization, while tetraspanin staining was readily observed following membrane permeabilization. Cationized ferritin was utilized to stain the plasma membrane, and revealed that the majority of virus-containing compartments were inaccessible to ferritin. Low molecular weight dextrans could access only a very small percentage of VCCs, and these tended to be more peripheral compartments. We conclude that the VCCs in monocyte-derived human macrophages are heterogeneous, but the majority of VCCs are closed to the external environment.
Genomic Analysis of Metastatic Solid Tumors in Veterans: Findings From the VHA National Precision Oncology Program (2019)

Clinical implementation of precision oncology is feasible across the VHA health care system, including rural sites. Veterans have unique occupational exposures that might inform the nature of the mutational signatures identified here. Importantly, these results underscore the importance of increasing clinical trial availability to veterans.
Effects of Experimental Sleep Restriction on Ambulatory and Sleep Blood Pressure in Healthy Young Adults: A Randomized Crossover Study (2021)

[Figure: see text].
Topology: its nature and significance (1962)

Modern mathematics emphasizes the study of patterns and structures, and one of the best examples of this emphasis is topology.
Strain Discontinuity, Avalanche, and Memory in Carbon Nanotube Serpentine Systems (2015)

This work addresses the problem of how a nano-object adheres to a supporting media. The case of study are the serpentine-like structures of single-wall carbon nanotubes (SWNTs) grown on vicinal crystalline quartz. We develop in situ nanomanipulation and confocal Raman spectroscopy in such systems, and to explain the results, we propose a dynamical equation in which static friction is treated phenomenologically and implemented as cutoff for velocities, via Heaviside step function and an adhesion force tensor. We demonstrate that the strain profiles observed along the SWNTs are due to anisotropic adhesion, adhesion discontinuities, strain avalanches, and memory effects. The equation is general enough to make predictions for various one- and two-dimensional nanosystems adhered to a supporting media.
Interplay of Orientational Order and Electronic Structure in Methylammonium Lead Iodide: Implications for Solar Cell Operation (2014)

FIGURE 1. Atlantapseudes brasiliensis sp. nov. Female (6.8mm). (a) dorsal view; (b) lateral view; (c) antennule; (d) antenna; (e) labrum; mandible (f) left, (g) right, (h) palp; (i) labium.
Synthesis of β-(4-Hydroxy-1-naphthyl)-DL-alanine1 (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of β-(4-Hydroxy-1-naphthyl)-DL-alanine1K. C. Tsou, Helen C. F. Su, R. B. Turner, and Ugo MirachiCite this: J. Med. Chem. 1966, 9, 1, 57–60Publication Date (Print):January 1, 1966Publication History Published online1 May 2002Published inissue 1 January 1966https://pubs.acs.org/doi/10.1021/jm00319a015https://doi.org/10.1021/jm00319a015research-articleACS PublicationsRequest reuse permissionsArticle Views77Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Polymer-Bound Bidentate-Phosphine-Palladium Complex as a Catalyst in the Heck Arylation (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Polymer-Bound Bidentate-Phosphine-Palladium Complex as a Catalyst in the Heck ArylationPei-Wei Wang and Marye Anne FoxCite this: J. Org. Chem. 1994, 59, 18, 5358–5364Publication Date (Print):September 1, 1994Publication History Published online1 May 2002Published inissue 1 September 1994https://pubs.acs.org/doi/10.1021/jo00097a043https://doi.org/10.1021/jo00097a043research-articleACS PublicationsRequest reuse permissionsArticle Views405Altmetric-Citations54LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Oxygen Vacancy-Related Cathodoluminescence Quenching and Polarons in CeO2 (2020)

We used cathodoluminescence (CL) spectroscopy to characterize the oxygen vacancies (V<sub>O</sub>) in ceria (CeO<sub>2</sub>). The effects of the processing atmosphere and thermal quenching temperature on the nature and distribution of the intrinsic defects and on the spectroscopic behavior were investigated. The presence of polarons and associates of the polarons with the oxygen vacancies such as (V<sub>O</sub> <sup>••</sup>-Ce<sub>Ce</sub> <sup>'</sup>)<sup>•</sup> is demonstrated. CL intensity quenching above a critical concentration of V<sub>O</sub> has been shown. Even though the emission centers in all samples are the same, their concentration changes with the oxygen partial pressure of the processing atmosphere. Deconvolution of the observed CL spectra shows that the emissions originating from the F<sup>0</sup> centers prevail over those of F<sup>+</sup> centers of V<sub>O</sub> when the defect concentration is high.
Photo-induced mass transfer in metal nanocluster doped glasses under continuous wave laser irradiation (2011)

Mass transfer accompanying continuous wave optical recording in glasses with embedded silver nanoclusters has been studied using optical microscopy, STEM and AFM. Recording was carried out by two crossed laser beams (514 nm), which created a periodic intensity distribution on the illuminated surface of the glass-silver composites. The quality of the recorded gratings was found to be independent of the light polarization. It was determined that laser irradiation induces two mass transfer processes: diffusion coalescence of nanoclusters and redistribution of silver between illuminated and nonilluminated interference lines. The temperature profile under the illuminated surface has been calculated, as well as the kinetics of the mass redistribution.
Digital system bus integrity (1987)

This report summarizes and describes the results of a study of current or emerging multiplex data buses as applicable to digital flight systems, particularly with regard to civil aircraft. Technology for pre-1995 and post-1995 timeframes has been delineated and critiqued relative to the requirements envisioned for those periods. The primary emphasis has been an assured airworthiness of the more prevalent type buses, with attention to attributes such as fault tolerance, environmental susceptibility, and problems under continuing investigation. Additionally, the capacity to certify systems relying on such buses has been addressed.
Briarellins J−P and Polyanthellin A:  New Eunicellin-Based Diterpenes from the Gorgonian Coral Briareum polyanthes and Their Antimalarial Activity (2003)

A new chemical study of the hexane extract of the gorgonian Briareum polyanthes collected in Puerto Rico afforded 10 new diterpenes of the eunicellin class, briarellins 1−9 and polyanthellin A (10), along with the known diterpene briarellin D (11). The structures and relative stereochemistry of metabolites 1−10 were assigned on the basis of NMR studies, chemical methods, and comparisons to the spectral properties of 11. A reassessment of prior structural assignment for briarellin A and two known sclerophytin-type diterpenes, 13 and 14, is proposed. Antimalarial tests on 1−6 and 8−12 indicated that they were active against Plasmodium falciparum.
Statistics of multipath component clustering in an office environment (2010)

In this paper, directional MIMO measurements in an indoor office environment are presented. A 5-D ESPRIT estimation algorithm is used to extract parameters associated with discrete propagation paths, such as their azimuth of arrival, azimuth of departure, delay, and power. The estimated path parameters are grouped into clusters using the statistical K-power-means algorithm. Statistical distributions are determined for the path parameters within individual clusters and for their change between clusters. To validate the distributional choices, the goodness-of-fit to the proposed distributions is verified using statistical hypothesis tests with sufficient power.
Ulipristal Acetate Versus Leuprolide Acetate for Uterine Fibroids (2013)

Current intervention strategies for management of uterine fibroids in women of reproductive age are primarily surgical or radiological. There are limited options for medical therapy. Two small placebo-controlled trials showed that ulipristal acetate, a selective progesterone-receptor modulator (SPRM), reduced fibroid and uterine sizes in women with symptomatic fibroids. The aim of this randomized, double-blind, controlled noninferiority trial was to determine whether ulipristal acetate was noninferior to leuprolide acetate in controlling bleeding before planned surgery in premenopausal women with symptomatic fibroids. Another aim was to compare the adverse effect profile of the 2 drugs. The participants, 307 patients with heavy uterine bleeding, were randomized to receive 3 months of daily therapy with oral ulipristal acetate (either 5 or 10 mg) or once-monthly intramuscular injections of leuprolide acetate (3.75 mg). The primary study outcome was the proportion of patients with controlled uterine bleeding at week 13. A prespecified noninferiority margin of −20% was used. Bleeding was controlled at 13 weeks in all 3 treatment groups; there was 90% control with the 5-mg dose of ulipristal acetate: 98% with the 10-mg dose versus 89% with the leuprolide acetate injection; the difference between ulipristal acetate and leuprolide acetate was 1.2 percentage points (95% confidence interval, −9.3 to 11.8) for the 5-mg dose and 8.8 percentage points (95% confidence interval, 0.4 to 18.3) for the 10-mg dose. Bleeding was attenuated more rapidly with ulipristal acetate than leuprolide acetate: median times to amenorrhea were 7 days in patients receiving 5 mg of ulipristal acetate and 5 days in those receiving 10 mg versus 21 days in those receiving leuprolide acetate. Moderate-to-severe hot flashes occurred less frequently in patients treated with ulipristal acetate than in those treated with leuprolide acetate: 11% with the 5-mg dose of ulipristal acetate and 10% with the 10-mg dose compared with 40% in those treated with leuprolide acetate (P < 0.001 for both comparisons). These findings show that daily doses of oral ulipristal acetate of both 5 and 10 mg were noninferior to once-monthly injections of leuprolide acetate in controlling bleeding in patients with fibroids and were less likely to cause hot flashes.
AN OPERANT APPROACH TO REHABILITATION MEDICINE: OVERCOMING LEARNED NONUSE BY SHAPING (1994)

A new approach to the rehabilitation of movement, based primarily on the principles of operant conditioning, was derived from research with deafferented monkeys. The analysis suggests that a certain proportion of excess motor disability after certain types of injury involves a learned suppression of movement and may be termed learned nonuse. Learned nonuse can be overcome by changing the contingencies of reinforcement so that they strongly favor use of an affected upper extremity in the chronic postinjury situation. The techniques employed here involved 2 weeks of restricting movement of the opposite (unaffected) extremity and training of the affected limb. Initial work with humans has been with chronic stroke patients for whom the approach has yielded large improvements in motor ability and functional independence. We report here preliminary data suggesting that shaping with verbal feedback further enhances the motor recovery.
Biomimetic titanium dioxide film with structural color and extremely stable hydrophilicity (2004)

We biomimeticly fabricated titanium dioxide films with three-dimensionally ordered structure. These films exhibit structural color, photocatalysis, and photoinduced superhydrophilicity. In addition, this biomimetic approach solves the problem of the stability of the superhydrophilicity of titanium dioxide.
HOUSE EXTRACTION WITH MULTIRESOLUTION ANALYSIS AND INFORMATION FUSION (1998)

ABSTRACT Houses are key elements both in aerial photographs and maps. Their extraction has significance not only to military, but also to automatical relative orientation, automatical absolute orientation, feature-based matching, systematic description, automatic data aquisition, structure analysis, image understanding, digital mapping, and construction of urban geographic information system (UGIS). For this purpose, this paper mainly addresses: (1) a brief introduction to the multiresolution analysis of wavelet theory and its difference form Laplacian pyramid, (2) how to generate the multiresolution images and edge features, and (3) how to employ these multiresolution images and edge features to extract the houses from aerial photographs by multiresolution structure and information fusion.
Classification of Normal Corneal Topography Based on Computer-Assisted Videokeratography (1990)

We evaluated the topography of 399 normal corneas in 212 subjects with computer-assisted videokeratography. The mean subject age was 37 years (range, 8 to 79 years). Mean spherical equivalent refraction was -1.00 diopters (range, +5.50 to -8.37 diopters). A qualitative classification system for corneal topography was derived based on patterns seen on color-coded topographic maps. Corneas were classified into groups by three independent masked ophthalmologists based on this system. Patterns included round (22.6%), oval (20.8%), symmetric bow tie (17.5%), asymmetric bow tie (32.1%), and irregular (7.1%). All corneas were steeper centrally and flatter peripherally. There was a statistically significant difference among patterns for keratometric astigmatism, but not for spherical equivalent refraction, mean keratometric power, or age of subject. Classification of normal corneal topography is an important step in the process of characterizing the shape of normal and pathologic corneas.
ChemInform Abstract: Molecular Aluminum Trihydride, AlH3: Generation in a Solid Noble Gas Matrix and Characterisation by Its Infrared Spectrum and ab initio Calculations. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Multilayer multipermittivity ring dielectric resonator antenna filter (2015)

ABSTRACT This article presents a multilayer multipermittivity (MLMP) ring dielectric resonator (DR) which is simultaneously used as a filter and an antenna, hence called dielectric resonator antenna filter. Multiple stacked layer of different permittivity along with the ring feature of DR gives a wideband response for antenna part with improved spurious response. In the presented MLMP ring DR, HEE 11 and TE 01δ modes are used for antenna and filter element, respectively. As HEE 11 and TE 01δ are orthogonal in nature that gives an independent control over filter and antenna characteristics. Measurement result reports an impedance bandwidth of 38.06% for dielectric resonator antenna (DRA) covering frequency range from 5 to 7.35 GHz for DRA and 3‐dB bandwidth is 211 MHz covering frequency range from 5.82 to 6.03 GHz for dielectric resonator filter (DRF). The measured resonance frequency is 5.38 and 5.93 GHz of DRA and DRF, respectively. © 2015 Wiley Periodicals, Inc. Microwave Opt Technol Lett 57:1147–1152, 2015
An Optimum Time Slot Assignment Algorithm for an SS/TDMA System with Variable Number of Transponders (1981)

In this paper we consider an SS/TDMA system with <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">M</tex> uplink beams, <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">N</tex> downlink beams, and <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">K, 1 \leq K \leq \min (M, N)</tex> transponders. An optimal time slot assignment algorithm for any <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">M, N, K,</tex> and any traffic matrix is presented, where optimality means achieving the minimal possible total duration for the given traffic matrix. The number of switching matrices generated by the algorithm is bounded above by <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">N^{2} - N + 1</tex> for <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">K = M = N</tex> and <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">MN + K + 1</tex> otherwise. Extensive simulation results on randomly generated matrices are carried out, showing that the average number of switching matrices generated is substantially lower than the bounds.
Dominating countably many forecasts (2014)

We investigate differences between a simple Dominance Principle applied to sums of fair prices for variables and dominance applied to sums of forecasts for variables scored by proper scoring rules. In particular, we consider differences when fair prices and forecasts correspond to finitely additive expectations and dominance is applied with infinitely many prices and/or forecasts.
Network Features of the Mammalian Circadian Clock (2009)

The mammalian circadian clock is a cell-autonomous system that drives oscillations in behavior and physiology in anticipation of daily environmental change. To assess the robustness of a human molecular clock, we systematically depleted known clock components and observed that circadian oscillations are maintained over a wide range of disruptions. We developed a novel strategy termed Gene Dosage Network Analysis (GDNA) in which small interfering RNA (siRNA)-induced dose-dependent changes in gene expression were used to build gene association networks consistent with known biochemical constraints. The use of multiple doses powered the analysis to uncover several novel network features of the circadian clock, including proportional responses and signal propagation through interacting genetic modules. We also observed several examples where a gene is up-regulated following knockdown of its paralog, suggesting the clock network utilizes active compensatory mechanisms rather than simple redundancy to confer robustness and maintain function. We propose that these network features act in concert as a genetic buffering system to maintain clock function in the face of genetic and environmental perturbation.
Poroelastic numerical modelling of natural and engineered cartilage based on in vitro tests (2006)

The mechanisms underlying the ability of articular cartilage to withstand and distribute the loads applied across diarthrodial joints have been widely studied. Experimental tests have been done under several configurations to reveal the tissue response to mechanical stimuli, and theoretical models have been developed for the interpretation of the experimental results. The experiments demonstrated that the tissue is non-linear with strain, both in tension and in compression, non-linear with direction of stimulus, anisotropic in tension and compression, non-homogeneous with depth, resulting in depth dependent mechanical properties, and presents fluid dependent and fluid independent viscoelasticity. None of the models up to now developed is able to describe the whole set of responses of such a complex tissue. The purpose of this study was to develop a combined experimental-numerical approach for the proper description of the cartilage response under confined and unconfined compression. We defined a series of experimental tests to be performed on disks of natural and engineered cartilage and we developed a numerical model for cartilage, based on the biphasic theory, which potentially includes the tension-compression non-linearity, the strain non-linearity and the fluid independent viscoelasticity. The model successfully simulated the confined and unconfined compression experiments performed on disks of natural and engineered cartilage, and was also used to identify parameters of difficult experimental evaluation, such as the collagen stiffness and the permeability. In conclusion, the use of our model in combination with biomechanical experimental testing seems a valuable tool to analyze the mechanical properties of natural cartilage and the biofunctionality of tissue engineered cartilage.