gebhart/patrepeval huggingface dataset:
Borrelia burgdorferi BmpA, BmpB, and BmpD Proteins Are Expressed in Human Infection and Contribute to P39 Immunoblot Reactivity in Patients with Lyme Disease (2005)

The Bmp proteins are a paralogous family of chromosomally encoded Borrelia burgdorferi lipoproteins. They have similar predicted immunogenicities and similar electrophoretic mobilities by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. P39 reactivity against Borrelia burgdorferi lysate in immunoblots of Lyme disease patients has long been identified with reactivity to BmpA, but responses to other Bmp proteins have not been examined. To determine if patients with Lyme disease developed such responses, immunoglobulin G (IgG) anti-Bmp reactivity in patient and control sera was studied by using soluble recombinant Bmp (rBmp) proteins expressed in Escherichia coli. Although some patient sera contained IgG immunoblot and immunodot reactivities against all four Bmp proteins, analysis of IgG anti-Bmp fine specificity by a competitive enzyme-linked immunosorbent assay with graded doses of soluble homologous and heterologous rBmp proteins showed that only the responses to BmpA, BmpB, and BmpD were specific. This suggests that at least three of the four Bmp proteins are expressed by B. burgdorferi in infected patients and that specific antibodies to them are likely to be present in the P39 band in some patients.
Discovery of a Highly Potent, Selective, and Bioavailable Soluble Epoxide Hydrolase Inhibitor with Excellent Ex Vivo Target Engagement (2009)

4-Substituted piperidine-derived trisubstituted ureas are reported as highly potent and selective inhibitors for sEH. The SAR outlines approaches to improve activity against sEH and reduce ion channel and CYP liability. With minimal off-target activity and a good PK profile, the benchmark 2d exhibited remarkable in vitro and ex vivo target engagement. The eutomer entA-2d also elicited vasodilation effect in rat mesenteric artery.
From Russia, With Chemistry (2020)

ADVERTISEMENT RETURN TO ISSUEEditor's PageNEXTFrom Russia, With Chemistry†Erick M. CarreiraErick M. CarreiraMore by Erick M. Carreirahttp://orcid.org/0000-0003-1472-490X, Valentine G. NenajdenkoValentine G. NenajdenkoMore by Valentine G. Nenajdenkohttp://orcid.org/0000-0001-9162-5169, Scott J. MillerScott J. MillerMore by Scott J. Millerhttp://orcid.org/0000-0001-7817-1318, Paul J. ChirikPaul J. ChirikMore by Paul J. Chirikhttp://orcid.org/0000-0001-8473-2898, and Karsten MeyerKarsten MeyerMore by Karsten Meyerhttp://orcid.org/0000-0002-7844-2998Cite this: Organometallics 2020, 39, 3, 375–377Publication Date (Web):January 31, 2020Publication History Published online31 January 2020Published inissue 10 February 2020https://pubs.acs.org/doi/10.1021/acs.organomet.0c00026https://doi.org/10.1021/acs.organomet.0c00026editorialACS PublicationsCopyright © 2020 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views2388Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (413 KB) Get e-AlertscloseSUBJECTS:Addition reactions,Carbonyls,Elimination reactions,Organic chemistry,Organic reactions Get e-Alerts
Encapsulation de chelates de Gadolinium dans des nanohydrogels de chitosane et d’acide hyaluronique : vers des sondes IRM hypersensibles (2018)

International audience
Utility of intraperitoneal administration as a route of AAV serotype 5 vector‐mediated neonatal gene transfer (2006)

AAV vector administration to neonates using the i.p. route was clearly advantageous in obtaining robust transgene expression. Vector genomes and transgene expression were observed mainly in the peritoneal tissue. These findings indicate the advantages of neonatal gene therapy and would help in designing strategies for gene therapy using AAV vectors.
Huile d’olive et santé osseuse (2014)

L'ostoporose reprsente un problme majeur de sant. La prise en charge classique de cette pathologie, essentiellement curative, est destine aux personnes qui ont exprim la maladie. Une telle stratgie ciblant la personne ge souffrant d'ostoporose svre s'avre trop tardive. En fait, le traitement idal de l'ostoporose, pour tre efficace, doit tre oral, dnu d'effet secondaire, et surtout prcoce de faon inhiber trs en amont le processus de perte osseuse. C'est pourquoi les stratgies de prvention visant rduire les risques d'ostoporose doivent tre dveloppes et instaures. Ainsi, le concept d'une alimentation saine, fournissant des quantits suffisantes de diffrents nutriments potentiellement ostoprotecteurs, mrite d'tre mentionn. Dans cette optique, les olives ou l'huile d'olive vierge sont des aliments fonctionnels intressants qui, en plus de leur richesse en acides gras mono-insaturs (acide olique), contiennent plusieurs composants polyphnoliques ayant des proprits biologiques spcifiques. Ils pourraient ainsi constituer des lments efficaces pour prvenir l'ostoporose, comme en tmoignent les donnes de la littrature.
HER2 Status and Efficacy of Adjuvant Anthracyclines in Early Breast Cancer: A Pooled Analysis of Randomized Trials (2007)

The added benefits of adjuvant chemotherapy with anthracyclines appear to be confined to women who have HER2 overexpressed or amplified breast tumors.
Scientific Opinion on the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs (2015)

This opinion describes the assessment of the risks to public health associated with bisphenol A (BPA) exposure. Exposure was assessed for various groups of the human population in three different ways: (1) external (by diet, drinking water, inhalation, and dermal contact to cosmetics and thermal paper); (2) internal exposure to total BPA (absorbed dose of BPA, sum of conjugated and unconjugated BPA); and (3) aggregated (from diet, dust, cosmetics and thermal paper), expressed as oral human equivalent dose (HED) referring to unconjugated BPA only. The estimated BPA dietary intake was highest in infants and toddlers (up to 0.875 µg/kg bw per day). Women of childbearing age had dietary exposures comparable to men of the same age (up to 0.388 µg/kg bw per day). The highest aggregated exposure of 1.449 µg/kg bw per day was estimated for adolescents. Biomonitoring data were in line with estimated internal exposure to total BPA from all sources. BPA toxicity was evaluated by a weight of evidence approach. “Likely” adverse effects in animals on kidney and mammary gland underwent benchmark dose (BMDL10) response modelling. A BMDL10 of 8 960 µg/kg bw per day was calculated for changes in the mean relative kidney weight in a two generation toxicity study in mice. No BMDL10 could be calculated for mammary gland effects. Using data on toxicokinetics, this BMDL10 was converted to an HED of 609 µg/kg bw per day. The CEF Panel applied a total uncertainty factor of 150 (for inter- and intra-species differences and uncertainty in mammary gland, reproductive, neurobehavioural, immune and metabolic system effects) to establish a temporary Tolerable Daily Intake (t-TDI) of 4 µg/kg bw per day. By comparing this t-TDI with the exposure estimates, the CEF Panel concluded that there is no health concern for any age group from dietary exposure and low health concern from aggregated exposure. The CEF Panel noted considerable uncertainty in the exposure estimates for non-dietary sources, whilst the uncertainty around dietary estimates was relatively low.
Clinical and microbiological aspects of the use of Lactobacillus rhamnosus PL1 strains in proctological patients with symptoms of chronic proctitis (2017)

Tthe probiotic Lactobacillus rhamnosus PL1 strain appears to be useful in restoring appropriate ratios of bacterial populations in patients presenting with symptoms of proctitis in the course of the treatment of certain diseases of the lower gastrointestinal tract.
Antibiotic-Resistant Invasive Pediatric Streptococcus pneumoniae Clones in Israel (2003)

Antibiotic-resistant international clones of Streptococcus pneumoniae are increasingly reported in different parts of the world. We investigated the spread of these clones through an active surveillance performed at the Israeli Streptococcal National Center during 1998 and 1999. Isolates were tested for antibiotic susceptibility, serotyped, and genotyped by random amplified polymorphic DNA analysis and pulsed-field gel electrophoresis. Of 437 isolates, 276 (63.4%) were antibiotic resistant and 156 (35%) were penicillin nonsusceptible (PNS). The PNS isolates were less frequently encountered in southern Israel (27 of 136 [20%]) than in other regions (127 of 301 [42%]). Among 276 antibiotic-resistant isolates, 43 fingerprint patterns were observed. The most common clones were 9V/14-a (19.2%), 5-a (17.8%), and 1-a (10%). The 9V/14-a clone was less common, while the 1-a clone was more frequent in the south than in other regions. The 5-a clone was more common in Jerusalem than in other regions. Among the Jewish and Arab populations the most frequent clones were 9V/14-a (20%) and 1-a (25%), respectively. Three international clones, 9V/14-a-Spain(9V)-3, 6B-a-Spain(6B)-2, and 5-a-Colombia(5)-19, comprised 40% of all antibiotic-resistant isolates and 56% of all PNS isolates. The seven-valent conjugate vaccine covers 58% of the most common clones, all highly PNS clones, and 94% of the multidrug-resistant clones in Israel, while the nine-valent vaccine covers all of them. The most common antibiotic-resistant invasive pediatric S. pneumoniae clones-mainly the three international ones-contribute significantly to increases in antibiotic resistance. Their geographic distribution varies within the country and between the different populations.
Realizing up and Downlink Subcarrier Allocation in Orthogonal Frequency Division Duplex (OFDD) Systems (2012)

In this paper we describe a new method for multicarrier systems that allows the allocation of different subcarriers to their up and downlinks. Techniques utilizing such subcarrier allocation have already been used in some cooperation and resource allocation algorithms for multiuser Orthogonal Frequency Division Multiple Access (OFDMA) as well as in Orthogonal Frequency Division Duplexing (OFDD). Therefore it is useful to investigate methods that can enable them. In this work we focus on the physical feasibility of the system since the radio impairments and system imperfections are the key challenges that need to be addressed. In particular we propose a baseband echo cancellation approach to mitigate the interference between the up and downlink subcarriers. An iterative echo canceller is utilized at the receiver, with the reference samples obtained from the output of the transmit power amplifier. The system performance in terms of output signal to interference and noise ratio (SINR) and bit error rate (BER) is evaluated by computer simulations based on the configuration of 802.11a/g systems.
Biased normalized cuts (2011)

We present a modification of “Normalized Cuts” to incorporate priors which can be used for constrained image segmentation. Compared to previous generalizations of “Normalized Cuts” which incorporate constraints, our technique has two advantages. First, we seek solutions which are sufficiently “correlated” with priors which allows us to use noisy top-down information, for example from an object detector. Second, given the spectral solution of the unconstrained problem, the solution of the constrained one can be computed in small additional time, which allows us to run the algorithm in an interactive mode. We compare our algorithm to other graph cut based algorithms and highlight the advantages.
Digital Control System Design (2001)

Central difference: e(k + 1)- e(k-1) 2T Although the central difference method provides the best results since it &quot;averages&quot; over two sample periods, a future error value is needed and so from a programming perspective it is not that useful. The same is true for the forward difference approximation. In general, then, the backward difference is commonly used to approximate the derivative term in our PID algorithm.
Moving discrete dissipative solitons in arrays of nonlinear cavities (2007)

We study nonlinear light dynamics in arrays of nonlinear cavities with cubic nonlinear response driven by an external inclined holding beam. We show analytically and numerically that both discreteness and inclination of the driving field can drastically change the conditions for modulational instability of light in dissipative systems. We find numerically the families of resting and moving discrete cavity solitons for arbitrary inclination of the driving field, both in discrete and continuous models. We analyze the crossover between stationary and moving cavity solitons and also study the novel collision features between these two types of dissipative solitons.
Organizing for Radical Product Innovation: The Overlooked Role of Willingness to Cannibalize (1998)

Why are some firms more successful at introducing radical product innovations than others? Following Schumpeter (1942), many researchers have suggested that firm size is the key organizational predictor of radical product innovation. The authors provide an alternate view and argue that one key variable that differentiates firms with strong radical product innovation records from others is the firms’ willingness to cannibalize their own investments. The authors identify three organizational factors that drive a firm's willingness to cannibalize. Results from a survey of three high-tech industries tend to support the alternate view that willingness to cannibalize is a more powerful driver of radical product innovation than firm size is. These results suggest a need to reconsider conventional wisdom on firm size, cannibalization, and organizational synergy.
ゾロアスター教 : 三五〇〇年の歴史 (2010)

ゾロアスター教の背景 ゾロアスターとその教え マズダー礼拝の確立 記録のない数世紀 アケメネス朝時代 セレウコス朝とアルサケス朝時代 サーサーン朝初期 サーサーン朝中期 サーサーン朝後期 カリフの時代 イル汗国—ラージャとスルタンの時代 サファビー朝とムガル朝時代 カージャール朝とイギリス支配の時代 二十世紀の状況〕
The Plasma Membrane–Associated NADH Oxidase of Spinach Leaves Responds to Blue Light (2002)

The plasma membrane-associated NADH oxidase (NOX) of spinach leaf disks is characterized by oscillations in activity with a regular period length of ca. 24 min. Within a single population of plants exposed to light at the same time, NOX activities of all plants function synchronously. Exposure of plants transferred from darkness to blue light (495 nm, 2 min, 50 micromoles m-2 s-1) resulted in a complex response pattern but with a new maximum in the rate of NOX activity 36 (24+12) min after illumination and then with maxima in the rate of NOX activity every 24 min thereafter. Transient maxima in NOX activity were observed as well after 9.3 + /- 1.4 and 20.7 +/- 2.1 min. The blue light response differed from the response to red (650 nm, 10 min, 50 micromoles m-2 s-1) or white light where activity maxima were initiated 12 min after the light exposure followed by maxima every 24 min thereafter. Green or yellow light was ineffective. The light response was independent of the time in the 24-min NOX cycle when the light was given. The net effects of blue and red light were ultimately the same with a new maximum in the rate of NOX activity at 12+24=36 min (and every 24 min thereafter), but the mechanisms appear to be distinct.
Ultrafast direct imprinting of nanostructures in metals by pulsed laser melting (2009)

We report a method of one-step direct patterning of metallic nanostructures. In the method, termed laser assisted direct imprinting (LADI), the surface of a metal film on a substrate is melted by a single excimer laser pulse and subsequently imprinted within approximately 100 ns using a transparent quartz mold, while the substrate is kept at a low temperature and in a solid phase. Using LADI, we imprinted gratings with approximately 100 nm linewidth, 100 nm depth, and 200 nm pitch, as well as isolated mesas of approximately 20 microm size, in Al, Au, Cu and Ni thin films. We found that the quartz mold was able to imprint metals even at temperatures higher than its melting point. The technique could be extended to other metals regardless of their ductility and hardness, and would find applications in photonic and plasmonic device production.
ChemInform Abstract: Aerobic Oxidation of Thiols to Disulfides Catalyzed by Diaryl Tellurides under Photosensitized Conditions. (2011)

Abstract It allows an efficient access to a wide range of disulfides.
Anal Valve movement and Normal Ventilation in Aeshnid Dragonfly Larvae (1972)

ABSTRACT Anal valve movement and abdominal sternal movement were photographed with a ciné camera during normal ventilation to obtain a correlation between the two parameters. As the sterna are raised (expiration) the anal valve opens to about one third of its maximum. At peak sternal movement the anal valve opens fully and these events mark the transition between expiration and inspiration. The anal valve finally closes towards the end of inspiration. The narrow aperture of the anal valve during expiration, coupled with the increase in pressure in the branchial chamber, causes the expired water to be forced well clear of the anus. Conversely, the wide aperture during inspiration and the small negative pressure in the branchial chamber ensure that water is drawn in from close to the animal, and so there is minimal mixing of expired water with inspired. The relationships between water flow, anal valve movement, branchial chamber pressure, sternal movement, pleural strain, and activity in certain expiratory and inspiratory muscles are discussed.
On the Quadratic Stability of Switched Interval Systems: Preliminary Results (2005)

In this paper we present some preliminary results on the quadratic stability of switched systems with uncertain parameters. We show that the quadratic stability of a class of switched uncertain systems may be readily verified using simple algebraic conditions. Examples are presented to demonstrate the efficacy of our techniques
CHAPTER 6. The Molecular Diversity of Conoidean Venom Peptides and their Targets: From Basic Research to Therapeutic Applications (2015)

The >10 000 species of venomous marine snails (superfamily Conoidea) have evolved sophisticated chemical strategies to interact with other animals in their environment. A conoidean venom typically contains 50–200 peptides unique to that species, each honed by natural selection to interact with a specific molecular target in the prey, predators or competitors of the snail. The diversity and molecular targeting specificity of conoidean venom peptides has provided sets of ligands that allow the pharmacological differentiation of different subtypes in large ion channel/receptor families (such as Na channels and nicotinic receptors). Conoidean venoms contain multiple sets of peptides, known as “cabals”, acting in concert on functionally linked molecular targets to achieve a specific physiological end-point, such as paralysis or excitotoxic shock. Each cabal targets a cognate “constellation” of receptors and ion channels in a physiological circuit. For example, the “motor cabal” causes neuromuscular paralysis, with different peptides of the cabal targeting specific motor constellation components, including Ca channels in motor neurons, Na channels and nAChRs in muscle. The elucidation of venom-peptide cabals and receptor/ion-channel constellations has inspired a new pharmacological paradigm called “Constellation Pharmacology” with the potential to transform both the discovery of novel pharmacological agents and the development of therapeutic drugs.
Uniaxial Alignment of Alq3 by Laser-Assisted Molecular Beam Epitaxy (2005)

The surface morphology of tris(8-hydroxyquinoline)aluminum(III) (Alq 3 ) epitaxially grown on KCl(001) was drastically changed by a simultaneous blue laser irradiation during vacuum deposition. Needle-shaped microcrystals were aligned to the polarization direction of the laser, parallel to the KCl[010] axis. The origin of alignment was discussed in comparison with the growth of non-polar organic molecular films, in which anisotropic heating played an important role.
Back Cover: Interdependency of surface morphology and wavelength fluctuations of indium‐rich InGaN/GaN quantum wells (Phys. Status Solidi A 5/2011) (2011)

The origin of indium fluctuations in indium-rich quantum wells is of high interest for direct green laser diodes. Teresa Lermer and co-authors (pp. 1199–1202) present the correlation of morphological features such as macro steps investigated by atomic force microscopy measurements and wavelength fluctuations seen in cathodoluminescence (CL) images of InGaN/GaN quantum wells (QW) grown by metal organic vapour phase epitaxy. The cover images show the low-temperature CL intensity plot (top left) and corresponding CL wavelength plot (top right) of the “green QW” test structure. On the bottom, a color coded intensity scan along the above yellow line is shown together with a sketch of the corresponding morphology and the different wavelength regimes. In their article, the authors present a growth model taking adsorption, desorption and migration processes into account to explain the difference of ultraviolet and green InGaN QW samples via a temperature dependent change in indium incorporation in the vicinity of the observed macro step edges.
A Joint Unitary Precoding and Scheduling Algorithm for MIMO-OFDM System with Limited Feedback (2007)

The capacity of MIMO-OFDM system can be increased substantially through spatial multiplexing with linear unitary precoding technique which requires that full channel state information should be sent back to transmitter. To reduce the feedback overhead, we give a codebook of precoding matrices that is known to both transmitter and receiver. A matrix is selected at the receiver, and then its index is conveyed to the transmitter using a small number of bits. In this work, we propose a new proportional fairness scheduler integrated with unitary precoding for MIMO-OFDM downlink system. The system-level simulation results show that the proposed scheduler achieves a better balance between optimizing cell throughput and guaranteeing fairness among users than other existing scheduler.