gebhart/patrepeval huggingface dataset:
SUPERSEDED - The 2nd Automatic Speaker Verification Spoofing and Countermeasures Challenge (ASVspoof 2017) Database (2017)

## This item has been replaced by the one which can be found at https://doi.org/10.7488/ds/2332 ## This is a database used for the Second Automatic Speaker Verification Spoofing and Countermeasuers Challenge, for short, ASVspoof 2017 (http://www.asvspoof.org) organized by Tomi Kinnunen, Md Sahidullah, Héctor Delgado, Massimiliano Todisco, Nicholas Evans, Junichi Yamagishi, Kong Aik Lee in 2017. The ASVspoof challenge aims to encourage further progress through (i) the collection and distribution of a standard dataset with varying spoofing attacks implemented with multiple, diverse algorithms and (ii) a series of competitive evaluations for automatic speaker verification. The ASVspoof 2017 challenge follows on from two special sessions on spoofing and countermeasures for automatic speaker verification held during INTERSPEECH 2013 and 2015. While the first edition in 2013 was targeted mainly at increasing awareness of the spoofing problem, the 2015 edition included a first challenge on the topic, with commonly defined evaluation data, metrics and protocols. The task in ASVspoof 2015 was to discriminate genuine human speech from speech produced using text-to-speech (TTS) and voice conversion (VC) attacks. The challenge was drawn upon state-of-the-art TTS and VC attacks data prepared for the “SAS” corpus by TTS and VC researchers. The primary technical goal of ASVspoof 2017 is to assess spoofing attack detection accuracy with ‘out in the wild’ conditions, thereby advancing research towards generalized spoofing countermeasure, in particular to detect replay. In addition, ASVspoof 2017 attempts to better interlink the research efforts from spoofing and text-dependent ASV communities. To this end, ASVspoof 2017 makes an extensive use of the recent text-dependent RedDots corpus, as well as a replayed version of the same data. The ASVspoof 2017 database contains large amount of speech data collected from 179 replay sessions in 125 unique replay configurations. Number of speakers is 42. A replay configuration means a unique combination of room, replay device and recording device, while a session refers to a set of source files, which share the same replay configuration.
Peripheral compressing artifacts in brain tissue from stereotactic biopsy with sidecutting biopsy needle: a pitfall for adequate glioma grading. (2011)

AIMS The stereotactic brain biopsy is an essential diagnostic procedure in modern neurologic patient management. A side-cutting biopsy needle is one of the most widely used needle types. Recently we found a characteristic tissue named peripheral compressing artifact in the brain tissues biopsied using a side-cutting needle of Leksell's system. We investigate prevalence, possible cause and its clinical implication of this type of artifact. MATERIALS AND METHODS We examined the biopsies from 80 patients (44 cases of gliomas, 13 lymphomas, 7 germ cell tumors, 2 other tumors, 1 metastatic carcinoma, 4 non-tumorous conditions such as demyelinating disease and 8 non-diagnostic) in the stereotactic biopsy group with a suspected brain tumor, who underwent a stereotactic brain biopsy using side-cutting needle of Leksell's system. We also evaluated 16 cases of open brain biopsies without Leksell's system as a control group. RESULTS The is a semi-circular or band-like tissue compression in the periphery of the biopsied tissue. This was found in 30 (37.5%) out of 80 cases and 57 (11.9%) out of 477 biopsied pieces. It might be produced during rotating of the inner cannula of the biopsy needle. Histologically, it might be misinterpreted as hypercellular, spindle, well circumscribed, or rarely as pseudopalisading especially in glioma. CONCLUSIONS Awareness of this would help making the appropriate pathological diagnosis for glioma.
Neue großtechnische Anwendungen des Reaktionsprinzips der zirkulierenden Wirbelschicht (1984)

Abstract New industrial applications of the circulating fluidized bed. Strongly expanding fluidized beds in the boundary region between fluidized bed and pneumatic conveying, which can achieve a steady state only by recirculation of the solids are of considerable importance for environmental protection because of the high gas flow rates and the high relative velocities possible between gas and solids in performing reactions between gases and fines with an average particle diameter less than 300 μm. Lurgi has utilized the principle of the circulating fluidized bed industrially both in the high temperature regime for the non‐pollutive production of process heat from low‐grade coal in a plant of 84 MW thermal rating and in the low temperature regime for adsorptive, dry purification of fluorine‐containing waste gases from aluminium electrolysis and for dry removal of pollutants from garbage‐burning power plants. This paper reports on the new process.
A randomized controlled trial of the effects of flaxseed lignan complex on metabolic syndrome composite score and bone mineral in older adults (2009)

A randomized double-blind placebo controlled study design was used to assess the effects of flaxseed lignan complex supplementation during exercise training on a metabolic syndrome composite score and osteoporosis risk in older adults. A total of 100 subjects (>or=50 years) were randomized to receive flaxseed lignan (543 mg.day-1 in a 4050 mg complex) or placebo while completing a 6 month walking program (30-60 min.day-1, 5-6 days.week-1). Fasting serum glucose, triacylglycerol (TAG), high-density lipoprotein (HDL) cholesterol, low-density lipoprotein cholesterol, total cholesterol, interleukin-6, and tumor necrosis factor-alpha were measured every 2 months, while body composition, bone mineral density, and resting blood pressure were assessed at baseline and at 6 months. A composite Z score of 6 risk factors for metabolic syndrome (fasting glucose, HDL cholesterol, TAG, abdominal adiposity, blood pressure, and inflammatory cytokines) was calculated at baseline and at 6 months. Men taking placebo increased metabolic syndrome composite Z score (p < 0.05), but there were no changes in the other groups. A significant group x sex x time interaction was noted for TAG (p = 0.017) and diastolic blood pressure (p = 0.046), with men taking flaxseed lignan decreasing diastolic blood pressure relative to men taking placebo, and men taking placebo increasing TAG relative to men taking flax lignan. There were no differences between groups for change in bone measures, body composition, lipoproteins, or cytokines. Males taking the flaxseed lignan complex reduced metabolic syndrome score relative to men taking placebo, but a similar trend was not seen in females. Flaxseed lignan had no effect on bone mineral density or content, body composition, lipoproteins, glucose, or inflammation.
A journey in the history of Automated Driving (2019)

Invited Pionneer's talk at IEEE/RSJ IROS 2019
Biologically active polymers. IV. Synthesis and antimicrobial activity of polymers containing 8‐hydroxyquinoline moiety (2001)

Abstract Polymers containing 8‐hydroxyquinoline moiety were prepared. Modifications of the base polymer of glycidyl methacrylate were carried out in order to introduce chloromethyl groups, either by the hydrolysis of the poly(glycidyl methacrylate) and the chloroacetylation of the hydrolyzed polymer by the reaction with chloroacetyl chloride or by aminating the poly(glycidyl methacrylate) either with ethylenediamine or with hexamethylenediamine, followed by reacting the aminated polymers with chloroacetyl chloride. The polymers containing 8‐hydroxyquinoline moiety were prepared by reacting the chloromethyl groups containing polymers with potassium salt of 8‐hydroxy quinoline. The antimicrobial activity of the polymers obtained was examined against gram‐negative bacteria ( Escherichia coli ) and gram‐positive bacteria ( Bacillus subtilus ) as well as the fungus Trichophyton rubrum. Generally, all three polymers proved effective against the tested microorganisms, but growth inhibitory effects varied from one another. © 2001 John Wiley &amp; Sons, Inc. J Appl Polym Sci 82: 1364–1374, 2001
Cloning of the ADPglucose pyrophosphorylase (glgC) and glycogen synthase (glgA) structural genes from Salmonella typhimurium LT2 (1987)

The structural genes of ADPglucose pyrophosphorylase (glgC) and glycogen synthase (glgA) from Salmonella typhimurium LT2 were cloned on a 5.8-kilobase-pair insert in the SalI site of pBR322. A single strand specific radioactive probe containing the N terminus of the Escherichia coli K-12 glgC gene in M13mp8 was used to hybridize against a S. typhimurium genomic library in lambda 1059. DNA from a plaque showing a positive hybridization signal was isolated, subcloned into pBR322, and transformed into E. coli K-12 RR1 and E. coli G6MD3 (a mutant with a deletion of the glg genes). Transformants were stained with iodine for the presence of glycogen. E. coli K-12 RR1 transformants stained dark brown, whereas G6MD3 transformants stained greenish yellow, and they both were shown to contain a 5.8-kilobase-pair insert in the SalI site of pBR322, designated pPL301. Enzyme assays of E. coli K-12 G6MD3 harboring pPL301 restored ADPglucose pyrophosphorylase and glycogen synthase activities. The specific activities of ADPglucose pyrophosphorylase and glycogen synthase in E. coli K-12 RR1(pPL301) were increased 6- to 7-fold and 13- to 15-fold, respectively. Immunological and kinetic studies showed that the expressed ADPglucose pyrophosphorylase activity in transformed E. coli K-12 G6MD3 cells was very similar to that of the wild-type enzyme.
Randomized, Multicenter, Warfarin-Controlled Phase II Study of Edoxaban in Japanese Patients With Non-Valvular Atrial Fibrillation (2012)

Edoxaban 30, 45, and 60mg QD in patients with NVAF was associated with a numerical increase in all bleeding across the dose range, but this was not statistically significant, nor was any dose compared with warfarin.
Early postextraction implants may achieve osseointegration in the absence of primary stability. A pilot study. (2020)

This pilot study aimed at investigating if implants without primary stability may osseointegrate and support functional prosthesis. Patients received one Trabecular Metal implant each in posterior sockets two months after tooth extraction, combined with xenograft and a resorbable membrane. Implants were divided in three groups, based on the primary stability assessed by resonance frequency analysis. Implant stability quotient (ISQ) was measured at placement, and re-assessed five months later (at uncovering), and after 6 months of function. Marginal bone loss was radiographically evaluated. After checking normality of the distributions, Student's t-test was used for statistical comparisons. Twenty-five consecutive patients were included. At placement, mean ISQ significantly differed among groups, being undetectable (n=8 implants), 65.00±4.25 (standard deviation, n=6) and 77.95±3.13 (n=11) in the very low, medium and good primary stability groups, respectively. After five months of healing, mean ISQ had increased to >70 in all groups. All implants successfully osseointegrated and were restored as planned. Six months after loading, no significant difference in mean ISQ (range 79.19-81.92), and in mean marginal bone level change (range 0.21 to 0.28 mm) was observed among the three groups. Rehabilitation of wide postextraction defects may achieve successful outcomes even in the absence of primary stability.
The role of leukocytes in the pathogenesis of fibrin deposition in bovine acute lung injury. (1991)

The peculiarly fibrinous nature of bovine acute lung injury due to infection with Pasteurella haemolytica A1 suggests an imbalance between leukocyte-directed procoagulant and profibrinolytic influences in the inflamed bovine lung. Calves with experimental pneumonia produced by intratracheal inoculation with P. haemolytica A1 developed acute locally extensive cranioventral fibrinopurulent bronchopneumonia. Pulmonary alveolar macrophages (PAM) recovered by segmental lavage from affected lung lobes were 30 times more procoagulant than PAM obtained from unaffected lung lobes and 37-fold more procoagulant than PAM from control calf lungs. Unlike the enhancement of procoagulant activity, profibrinolytic activity (plasminogen activator amidolysis) of total lung leukocytes (PAM and plasminogen activator neutrophils [PMN]) was decreased 23 times in cells obtained from affected lung lobes and also was decreased four times in cells obtained from unaffected lobes of infected animals. This marked imbalance in cellular procoagulant and fibrinolytic activity probably contributes significantly to enhanced fibrin deposition and retarded fibrin removal. In addition, PAM from inflamed lungs were strongly positive for bovine tissue factor antigen as demonstrated by immunocytochemistry. Intensely tissue factor-positive PAM enmeshed in fibrinocellular exudates and positive alveolar walls were situated such that they were likely to have, in concert, initiated extrinsic activation of coagulation in the acutely inflamed lung. These data collectively suggest that enhanced PAM-directed procoagulant activity and diminished PAM- and PMN-directed profibrinolytic activity represent important modifications of local leukocyte function in bovine acute lung injury that are central to the pathogenesis of lesion development with extensive fibrin deposition and retarded fibrin removal.
Quantifying Competition among Mitochondrial Protein Acylation Events Induced by Ethanol Metabolism (2019)

Mitochondrial dysfunction is one of many key factors in the etiology of alcoholic liver disease (ALD). Lysine acetylation is known to regulate numerous mitochondrial metabolic pathways, and recent reports demonstrate that alcohol-induced protein acylation negatively impacts these processes. To identify regulatory mechanisms attributed to alcohol-induced protein post-translational modifications, we employed a model of alcohol consumption within the context of wild type (WT), sirtuin 3 knockout (SIRT3 KO), and sirtuin 5 knockout (SIRT5 KO) mice to manipulate hepatic mitochondrial protein acylation. Mitochondrial fractions were examined by label-free quantitative HPLC-MS/MS to reveal competition between lysine acetylation and succinylation. A class of proteins defined as "differential acyl switching proteins" demonstrate select sensitivity to alcohol-induced protein acylation. A number of these proteins reveal saturated lysine-site occupancy, suggesting a significant level of differential stoichiometry in the setting of ethanol consumption. We hypothesize that ethanol downregulates numerous mitochondrial metabolic pathways through differential acyl switching proteins. Data are available via ProteomeXchange with identifier PXD012089.
Prediction of Cellular Radiosensitivity from DNA Damage Induced by .GAMMA.-Rays and Carbon Ion Irradiation in Canine Tumor Cells (2005)

Diseases of companion animals are shifting from infectious diseases to neoplasms (cancer), and since radiation therapy is one of the effective choices available for cancer treatment, the application of radiotherapy in veterinary medicine is likely to increase. However tumor tissues have different radiosensitivities, and therefore it is important to determine the intrinsic radiosensitivity of tumors in individual patients in advance of radiotherapy. We have studied the relationship between the surviving cell fraction measured by a clonogenic assay and DNA double strand breaks detected by a comet assay under neutral conditions in three canine tumor cell lines, after gamma-ray and carbon ion irradiation. In all the cell lines, cell death assessed by the clonogenic assay was much higher following irradiation with carbon ions than with gamma-rays. The initial and residual (4 hr) DNA damage due to gamma-ray and carbon ion irradiation were higher in a radiosensitive cell line than in a radioresistant cell line. The surviving cell fraction at 2 Gy (SF2) showed a tendency for correlation with both the initial and residual DNA damage. In particular, the residual damage per Gy was significantly correlated with SF2, regardless of the type of radiation. This indicates that cellular radiosensitivity can be predicted by detection of radiation-induced residual DNA damage.
Initial management of suspected meningococcal infection: Parenteral benzylpenicillin is vital (1994)

ordinary people would not be expected to regard local authority boundaries as marking their com- munities and would not consider their culture to be shaped by the "common media" of council affairs.Watkins's community is one of local institutions.
Anti-phospholipid antibodies and biological false positive serological test for syphilis in patients with systemic lupus erythematosus. (1984)

Utilizing a newly developed solid phase enzyme immunoassay for the detection of anti-phospholipid antibodies, we found that 41.7% of sera from patients with active systemic lupus erythematosus (SLE) had the anti-cardiolipin antibody and 22.7% of sera were positive for the anti-phosphatidylinositol (PI) antibody. But antibodies to lecithin, cephalin and sphingomyelin were rarely found in this assay. We also examined antibodies to the VDRL (Venereal Disease Research Laboratory) antigen which consists of cardiolipin-cholesterol-lecithin mixtures. The incidence of the anti-VDRL antibody in the IgG class was 29.2% and 25% in the IgM class, and the magnitude of these antibodies correlated well with the incidence of biological false positive serological test for syphilis (BFP-STS), but no association between the anti-VDRL antibody titre and the anti-cardiolipin antibody titre was observed. Furthermore, the cardiolipin binding activity of sera from patients with SLE was inhibited by DNA and poly(I), both of which have polynucleotide backbones structurally similar to the phosphodiester groups of cardiolipin. On the contrary, these polynucleotides failed to inhibit the PI and the VDRL binding of SLE sera. These observations may support the concept that the anti-cardiolipin antibody in sera from patients with SLE might be a part of the anti-DNA antibodies, which are serologically polymorphic in that they can react with a variety of polynucleotides, but differ from the BFP reactors.
A phosphatidylinositol transfer protein integrates phosphoinositide signaling with lipid droplet metabolism to regulate a developmental program of nutrient stress–induced membrane biogenesis (2014)

Lipid droplet (LD) utilization is an important cellular activity that regulates energy balance and release of lipid second messengers. Because fatty acids exhibit both beneficial and toxic properties, their release from LDs must be controlled. Here we demonstrate that yeast Sfh3, an unusual Sec14-like phosphatidylinositol transfer protein, is an LD-associated protein that inhibits lipid mobilization from these particles. We further document a complex biochemical diversification of LDs during sporulation in which Sfh3 and select other LD proteins redistribute into discrete LD subpopulations. The data show that Sfh3 modulates the efficiency with which a neutral lipid hydrolase-rich LD subclass is consumed during biogenesis of specialized membrane envelopes that package replicated haploid meiotic genomes. These results present novel insights into the interface between phosphoinositide signaling and developmental regulation of LD metabolism and unveil meiosis-specific aspects of Sfh3 (and phosphoinositide) biology that are invisible to contemporary haploid-centric cell biological, proteomic, and functional genomics approaches.
Evolution of antiferromagnetic susceptibility under uniaxial pressure in Ba(Fe1−xCox)2As2 (2014)

Neutron diffraction measurements are presented measuring the responses of both magnetic and structural order parameters of parent and lightly Co-doped Ba(${\mathrm{Fe}}_{1\ensuremath{-}x}{\mathrm{Co}}_{x}$)${}_{2}{\mathrm{As}}_{2}$ under the application of uniaxial pressure. We find that the uniaxial pressure induces a thermal shift in the onset of antiferromagnetic order that grows as a percentage of ${T}_{N}$ as Co doping is increased and the superconducting phase is approached. Additionally, as uniaxial pressure is increased within parent and lightly doped Ba(${\mathrm{Fe}}_{1\ensuremath{-}x}{\mathrm{Co}}_{x}$)${}_{2}{\mathrm{As}}_{2}$ on the first-order side of the tricritical point, we observe a decoupling between the onsets of the orthorhombic structural distortion and antiferromagnetism. Our findings place needed constraints on models exploring the nematic susceptibility of the bilayer pnictides in the tetragonal, paramagnetic regime.
A novel sanitation model based on EcoSan philosophy. (2009)

Zero Discharge Toilet System (ZDTS) which incorporates EcoSan philosophy and the advantages of\nwater flushed system has been described in this paper. The system uses a solidliquid\nseparator and a\nthin flat filter which enables recycling for flushing the toilet pan and separate collection of urine and\nfecal slurry. Inorganic liquid or solid fertilizer is obtained by concentrating the liquid residue. The solid\nresidues containing around 2 % solids are first processed using activated composting and finally\npolished to obtain quality organic manure using vermicomposting. The quality of product is much\nsuperior as indicated by higher water holding capacity and much lower total carbon, volatile solids,\ncoliforms and C/N ratio. The zero discharge toilets are well accepted among users. The residues\ngenerated per person are about 1/5 th as compared to conventional toilet system. ZDTS has lower capital\ncost and higher NPV as compared to conventional wastewater treatment system.
Time-Resolved Spectroscopic Studies on the TE HF Chemical Lasers Using the Mixtures of SF6/H2and SF6/CH4 (1974)

HF chemical laser emission was obtained on a large number of P-branch lines in the 3–2, 2–1 and 1–0 vibrational bands. Time-resolved spectroscopy of the P-branch lines showed that the P2→1(J) line (J=5∼8) started lasing first and the onsets of the P3→2(J-1) and P1→0(J+1) lines were delayed from it, and that the P3→2(J-1) was weaker than either of the other two lines. The ratios of the vibrational populations contributing to the laser emission and the relative HF laser gains of the three vibrational transitions were calculated. There results were consistent with the temporal behavior of the P-branch lines. The time sequence of the individual laser lines were found to be quite similar for both cases where H2 and CH4 were used as the hydrogen donors. This means that both chemical pumping reactions are quite similar.
Near-Infrared Quantum Dot and 89Zr Dual-Labeled Nanoparticles for in Vivo Cerenkov Imaging (2016)

Cerenkov luminescence (CL) is an emerging imaging modality that utilizes the light generated during the radioactive decay of many clinical used isotopes. Although it is increasingly used for background-free imaging and deep tissue photodynamic therapy, in vivo applications of CL suffer from limited tissue penetration. Here, we propose to use quantum dots (QDs) as spectral converters that can transfer the CL UV-blue emissions to near-infrared light that is less scattered or absorbed in vivo. Experiments on tissue phantoms showed enhanced penetration depth and increased transmitted intensity for CL in the presence of near-infrared (NIR) QDs. To realize this concept for in vivo imaging applications, we developed three types of NIR QDs and <sup>89</sup>Zr dual-labeled nanoparticles based on lipid micelles, nanoemulsions, and polymeric nanoplatforms, which enable codelivery of the radionuclide and the QDs for maximized spectral conversion efficiency. We finally demonstrated the application of these self-illuminating nanoparticles for imaging of lymph nodes and tumors in a prostate cancer mouse model.