gebhart/patrepeval huggingface dataset:
Determining Anisotropic Formation Resistivity at Any Relative Dip Using a Multiarray Triaxial Induction Tool (2006)

Abstract Thin-bedded sand-shale sequences frequently exhibit resistivity anisotropy. That is, resistivity measured perpendicular to the bedding (Rv) is significantly higher than the resistivity measured parallel to the bedding (Rh). It is difficult to determine water saturation in these sequences using standard induction logs that respond primarily to Rh, regardless of relative dip angle. If conductive shale laminations are present, the water saturation is over estimated; equivalently, hydrocarbon in place is underestimated. A recently introduced triaxial induction tool provides several 3×3 tensor measurements that are sensitive to Rh, Rv and formation dip. A fast and rigorous inversion of triaxial induction data provides logs of Rh, and Rv without shoulder bed effect, and also provides logs of formation dip. The robustness of the inversion algorithm has been validated with synthetic log data. A petrophysical model has been developed that computes both sand resistivity (Rsand) and shale resistivity (Rshale) from Rh and Rv logs. Fraction of shale, determined using established log interpretation techniques, is an input to the model. Since the induction measurement is relatively deep, the uncertainty in water saturation using the model is greatly reduced compared to interpretation models that use microresistivity logs. Case studies from oilfields around the world demonstrate the utility of triaxial induction measurements for formation evaluation. Data were acquired in a wide variety of borehole and formation environments. These include oil-based mud, waterbase mud, dipping formations, vertical wells, deviated wells, and a wide-range of borehole sizes. Low resistivity pay zones were identified that might otherwise be missed with standard induction logs. Microresistivity images confirmed the presence of thin laminations and confirmed the dip measurements from the triaxial induction.
Feedlot performances: comparaison of beef cattle anabolized with trenbolone acetate-zeranol or trenbolone acetate-oestradiol implantation in beef cattle (1983)

peer reviewed
Effect of Antihemostatic Agents on Experimental Tumor Dissemination (2002)

There is now considerable evidence that the blood coagulation system plays an important role in the biology of malignant tumors. This evidence has been derived from a combination of clinical, biochemical, histological, and pharmacological observations that point to the possibility of favorably affecting the course of malignant disease with agents that interfere with blood coagulation pathways. For a number of years our laboratory has used experimental models of blood-borne metastasis to study the events that follow the introduction of procoagulant-bearing tumor cells into the circulating blood. This article summarizes our experience with these models, which suggests that intravascular coagulation is a necessary prelude to lung tumor formation and that interruption of coagulation pathways in various ways may be an effective antimetastatic strategy. We have shown that anticoagulation with commonly used agents such as unfractionated heparin and warfarin (Coumadin) prevent tumor formation by limiting the ability of tumor cells to be retained in the pulmonary microvasculature. Binding of fibrin-coated tumor cells to activated platelets is essential for this retention and, therefore, treatment with potent antiplatelet agents such as abciximab is also effective. The predominant tumor procoagulant is tissue factor (TF), and direct targeting of this protein with concanavalin A, monoclonal antibodies, and tissue factor pathway inhibitor (TFPI) has provided compelling evidence that TF is an important determinant of tumor seeding in these experimental models. Collectively, our data provide strong support for the concept that some form of anticoagulant therapy would be a useful adjunct to existing cancer treatments.
Developing Insecticide Resistance in Insect and Mite Predators and Opportunities for Gene Transfer (1987)

Genetic selection of predatory insects and mites for pesticide resistance has been successful and resistant strains of the western predatory mite, Metaseiulus occidentalis, are being commercially implemented in California almond orchards. Multi-resistant strains of M. occidentalis were developed that are resistant to carbaryl, sulfur, permethrin and organophosphorus insecticides. The common green lacewing, Chrysoperla carnea, also was selected in the laboratory and this predatory insect developed a high level of carbaryl resistance. Whether parasitoids can be selected for a high level of resistance remains unknown. However, the development of resistant parasitoids and predators could lead to their enhanced use in agricultural crop systems where key insect pests must be controlled chemically. Because pesticide resistances are often determined by single major genes, gene transfer techniques should be feasible if the resistance genes can be identified, cloned, transferred to recipient species with a suitable vector, stably and appropriately expressed in the recipients, and transmitted to their progeny.
The fluorescence excitation spectra of aromatic liquids and solutions (1968)

The fluorescence excitation spectra of liquid benzene, toluene, p-xylene, mesitylene, 2-methylnaphthalene, 1,6-dimethylnaphthalene, naphthalene, fluorobenzene and fluoronaphthalene, and of cyclohexane solutions of the first six compounds, were observed in deoxygenated systems at wavelengths not less than 195 nm. The observed dependence of the relative fluorescence yield on excitation wavelength and concentration is analysed in terms of a model kinetic scheme involving the formation of higher excimer states D** from the higher excited molecular states X**. Data are obtained on the relative efficiencies of internal conversion from X** and D** to the corresponding fluorescent states. The nature of the competing processes is discussed.
Reactions of the Conjugated Dienes Butadiene and Isoprene Alone and with Methanol Over Ion-Exchanged Montmorillonites (1986)

Abstract The reactions of simple conjugated dienes over divalent and trivalent transition metal-exchanged montmorillonites yield, in the absence of nucleophiles, a variety of products. Some of these products are a result of Diels-Alder cycloaddition reactions, whereas others are indicative of carbocation intermediates, i.e., other dimers, oligomers, and isomerization products of these intermediates. The reactions in sealed cells between 20° and 150°C show trends in the yields of the various product groups. Dimers of butadiene and isoprene formed by cycloaddition (i.e., 4-vinylcyclohexene and the monoterpene p-menthadiene (limonene)) were formed at low temperatures (20–50°C). As the temperature was raised, the total yield of dimers increased and higher oligomers were formed along with isomerization products of the dimers and oligomers. The products of cycloaddition, however, did not increase markedly. The type of solvent used for the reaction was found to influence the reactivity, e.g., the use of 1,4-dioxan rather than chloroform led to a reduction in total conversion and also to a markedly higher degree of selectivity. In the presence of a suitable nucleophile (methanol), both dienes gave the 1,4-addition product predominantly, which suggests that an allylic carbocation intermediate was involved. The use of an interlayer-supported nickel complex, [HNi(P(OEt) 3 ) 4 ] + , produced the only large scale polymerization observed in this work.
Metformin encapsulated gold nanoparticles (MTF‐GNPs): A promising antiglycation agent (2022)

The generation of advanced glycation end products (AGEs) through nonenzymatic protein glycation contributes to the pathogenesis of long-lived diabetic problems. Metformin (MTF) is the very first drug having antihyperglycemic effects on type II diabetes mellitus which also possess interaction with dicarbonyl compounds and blocks the formation of AGEs. In the current study, MTF is bioconjugated with glycation-derived synthesized gold nanoparticles (GNPs) of significant size. Additionally, using various biophysical and biochemical approaches, we investigated the antiglycating capacity MTF-GNPs in contrast to MTF against d-ribose-derived glycation of bovine serum albumin. Our key findings via utilizing various assays demonstrated that MTF-GNPs were able to inhibit AGEs development by reducing hyperchromicity, early glycation products, carbonyl content, hydxoxymethylfurfural content, production of fluorescent AGEs, normalizing the loss of secondary structure (i.e., α-helix and β-sheets) of proteins, elevating the levels of free lysine and free arginine more efficiently compared to pure MTF. Based on these results, we concluded that MTF-GNPs possess a considerable antiglycation property and may be developed as an outstanding anti-AGEs treatment drug. Further in vivo and clinical research are necessary to determine the therapeutic effects of MTF-GNPs against AGE-related and metabolic disorders.
The gcvB gene encodes a small untranslated RNA involved in expression of the dipeptide and oligopeptide transport systems in Escherichia coli (2000)

The Escherichia coli gcvB gene encodes a small RNA transcript that is not translated in vivo. Transcription from the gcvB promoter is activated by the GcvA protein and repressed by the GcvR protein, the transcriptional regulators of the gcvTHP operon encoding the enzymes of the glycine cleavage system. A strain carrying a chromosomal deletion of gcvB exhibits normal regulation of gcvTHP expression and glycine cleavage enzyme activity. However, this mutant has high constitutive synthesis of OppA and DppA, the periplasmic-binding protein components of the two major peptide transport systems normally repressed in cells growing in rich medium. The altered regulation of oppA and dppA was also demonstrated using oppA-phoA and dppA-lacZ gene fusions. Although the mechanism(s) involving gcvB in the repression of these two genes is not known, oppA regulation appears to be at the translational level, whereas dppA regulation occurs at the mRNA level.
Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain (2016)

Chemotherapy-induced peripheral neuropathic pain (CIPNP) is a severe dose- and therapy-limiting side effect of widely used cytostatics that is particularly difficult to treat. Here, we report increased expression of the cytochrome-P<sub>450</sub>-epoxygenase CYP2J6 and increased concentrations of its linoleic acid metabolite 9,10-EpOME (9,10-epoxy-12Z-octadecenoic acid) in dorsal root ganglia (DRGs) of paclitaxel-treated mice as a model of CIPNP. The lipid sensitizes TRPV1 ion channels in primary sensory neurons and causes increased frequency of spontaneous excitatory postsynaptic currents in spinal cord nociceptive neurons, increased CGRP release from sciatic nerves and DRGs, and a reduction in mechanical and thermal pain hypersensitivity. In a drug repurposing screen targeting CYP2J2, the human ortholog of murine CYP2J6, we identified telmisartan, a widely used angiotensin II receptor antagonist, as a potent inhibitor. In a translational approach, administration of telmisartan reduces EpOME concentrations in DRGs and in plasma and reverses mechanical hypersensitivity in paclitaxel-treated mice. We therefore suggest inhibition of CYP2J isoforms with telmisartan as a treatment option for paclitaxel-induced neuropathic pain.
Transient thermal analysis of power devices based on Fourier-series thermal model (2008)

A new thermal model based on Fourier series expansion method has been presented for dynamic thermal analysis on power devices. The thermal model based on the Fourier series method has been programmed in MATLAB SIMULINK and integrated with a physics-based electrical model previously reported. The model was verified for accuracy using a two-dimensional Fourier model and a two-dimensional finite difference model for comparison. To validate this thermal model, experiments using a 600 V 50 A IGBT module switching an inductive load, has been completed under high frequency operation. The result of the thermal measurement shows an excellent match with the simulated temperature variations and temperature time-response within the power module.
Table S4 from Epigenetic Identity in AML Depends on Disruption of Nonpromoter Regulatory Elements and Is Affected by Antagonistic Effects of Mutations in Epigenetic Modifiers (2023)

&lt;p&gt;DMC identity and annotation for IDH2, DNMT3A, and IDH1/DNMT3A cohorts.&lt;/p&gt;
P2‐059: Intraneuronal Amylin Deposition, Peroxidative Membrane Injury and Increased IL‐1SS Synthesis in Brains of Alzheimer’s Disease Patients with Type‐2 Diabetes and Diabetic Hip Rats (2016)

Recent studies, including work from our laboratory, suggest that type-2 diabetes is linked with Alzheimer’s disease (AD) by the interaction of amylin (also known as islet amyloid polypeptide) with ß amyloid pathology. Here, we sought to spectroscopically authenticate the presence of amylin in AD brains and identify specific amylin-mediated neurotoxic mechanisms. The presence of amylin in brain specimens from AD patients with type-2 diabetes (n=4) was tested by liquid chromatography tandem mass spectrometry (LC-MS/MS). To decipher amylin-mediated neurotoxicity, we investigated tissue specimens from humans, compared human amylin-expressing (HIP) rats (n=15) with age- and glucose-matched diabetic rats expressing only endogenous non-amyloidogenic rat amylin (n=15), studied mice injected with aggregated human amylin versus controls (n=10 per group) and developed in vitro cell models. LC-MS/MS data convincingly demonstrated that amylin is contained in brain lysates from AD patients. In addition to amylin plaques and mixed amylin-ß amyloid deposits, brains of diabetic patients with AD show amylin immunoreactive deposits inside the neurons. Neuronal amylin formed adducts with 4-hydroxynonenal (4-HNE), a marker of peroxidative membrane injury, and increased (by 45% vs. control; P<0.001) synthesis of the proinflammatory cytokine interleukin (IL)-1ß. These pathological changes were mirrored in rats expressing human amylin in pancreatic islets (HIP rats) and mice intravenously injected with aggregated human amylin, but not in hyperglycemic rats secreting wild-type non-amyloidogenic rat amylin. In cultured primary hippocampal rat neurons, aggregated amylin increased IL-1ß synthesis via membrane destabilization and subsequent generation of 4-HNE. These effects were blocked by membrane stabilizers and lipid peroxidation inhibitors. Elevated blood levels of aggregated amylin can promote brain accumulation of amylin leading to peroxidative membrane injury and aberrant inflammatory responses independent of other confounding factors of diabetes. Present results are consistent with the pathological role of aggregated amylin in the pancreas, demonstrate a novel contributing mechanism to neurodegeneration and suggest a direct, potentially treatable link of type-2 diabetes with AD.
Gas heating and plasma expansion in pulsed microwave-excited microplasmas (2015)

Microwave resonators are used to generate microplasmas in atmospheric-pressure argon and helium. We present observations of the transient behavior of a microplasma after a fast increase in power, including time-resolved photography and spectroscopic gas temperature measurements. The results show that in argon both plasma filamentation and gas heating continue out to millisecond time scales, while helium microplasmas reach steady-state conditions after a few microseconds.
An update on gene therapy programs (2009)

This commentary discusses the most significant advances that were presented at the 12th Annual Meeting of the American Society of Gene Therapy. Many reports focused on clinical trials for the treatment of cancer and other pathological conditions, preclinical studies for various diseases, genetic immunization protocols and improvement of vector design. In this respect, a major emphasis was placed on safety issues.
(Recombinant DNA; phage I pL promoter; c repressor; clear-plaque phenotype; protein processing; protease- deficient Escherichiu coli B ; thermoinducible Ner-mediated immunity; prophage; lysogeny) (1988)

SUMMARY The construction is described of a plasmid (pL-ner) which directs the high-level production of the bacteriophage Mu Ner protein in Escherichia cob. The protein, recovered in the soluble cellular fraction, was susceptible to in vivo proteolytic processing, in many host strains, but not in E. coli B, a natural Zen - prototroph. A simple purification method is described which takes advantage of the basic nature of the protein. The purified protein was shown to be physically and chemically homogeneous and to have an amino acid sequence identical to that predicted for the authentic protein. The protein was also shown to have in vitro biological activity, as measured by specific binding to a DNA fragment containing the consensus Ner-binding sequence, and in vivo biological activity as the protein produced by the pL-ner plasmid allowed lysogenic-like maintenance of a Mu prophage c mutant unable to synthesise a functional Mu repressor.
ASC Tri-lab Co-design Level 2 Milestone Report 2015 (2015)

In 2015, the three Department of Energy (DOE) National Laboratories that make up the Advanced Sci- enti c Computing (ASC) Program (Sandia, Lawrence Livermore, and Los Alamos) collaboratively explored performance portability programming environments in the context of several ASC co-design proxy applica- tions as part of a tri-lab L2 milestone executed by the co-design teams at each laboratory. The programming environments that were studied included Kokkos (developed at Sandia), RAJA (LLNL), and Legion (Stan- ford University). The proxy apps studied included: miniAero, LULESH, CoMD, Kripke, and SNAP. These programming models and proxy-apps are described herein. Each lab focused on a particular combination of abstractions and proxy apps, with the goal of assessing performance portability using those. Performance portability was determined by: a) the ability to run a single application source code on multiple advanced architectures, b) comparing runtime performance between \native" and \portable" implementations, and c) the degree to which these abstractions can improve programmer productivity by allowing non-portable implementation details to be hidden from the application developer. This report captures the work that was completed for this milestone, and outlines future co-design work to be performed by application developers, programming environment developers, compiler writers, and hardware vendors.
Detection for binary transmission in a mixture of Gaussian noise and impulsive noise modeled as an alpha-stable process (1994)

The impact of nonGaussian impulsive noise combined with Gaussian noise on the performance of the binary transmission is analyzed. The impulsive noise is modeled as an alpha-stable process. The probability of error for optimum, linear and nonlinear receivers is derived. The proposed nonlinear detectors show substantial improvements in performance compared to linear ones. The obtained results will be useful in performance evaluation of digital communication links subject to Gaussian and impulsive noises.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Salivary exosomal PSMA7: a promising biomarker of inflammatory bowel disease (2017)

Inflammatory bowel disease (IBD) is an intestinal immune-dysfunctional disease worldwide whose prevalence increasing in Asia including China. It is a chronic disease of the gastrointestinal tract with unknown cause. Exosomes are small vesicles in various body fluids. They have diameters of 40-120 nm, and one of their functions is long-distance transfer of various substances. In this study, we investigated the contents of salivary exosomes in patients with IBD and in healthy controls to explore a new biomarker in patients with IBD. In this study, whole saliva was obtained from patients with IBD (ulcerative colitis (UC), n = 37; Crohn's disease (CD), n = 11) and apparently healthy individuals (HC, n = 10). Salivary exosomes were extracted from samples, and the proteins within the exosomes were identified by liquid chromatograph-mass spectrometer (LC-MS/MS). The results showed that more than 2000 proteins were detected in salivary exosomes from patients with IBD. Through gene ontology analysis, we found that proteasome subunit alpha type 7 (PSMA7) showed especially marked differences between patients with IBD and the healthy controls, in that its expression level was much higher in the CD and UC groups. This exosomal protein is related to proteasome activity and inflammatory responses. So we conclude that in this research, salivary exosomal PSMA7 was present at high levels in salivary exosomes from subjects with IBD. It can be a very promising biomarker to release the patients from the pain of colonoscopy.
A NEW SOLVENT EXTRACTION METHOD FOR THE SEPARATION OF NIOBIUM AND TANTALUM (1952)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA NEW SOLVENT EXTRACTION METHOD FOR THE SEPARATION OF NIOBIUM AND TANTALUMG. W. Leddicotte and F. L. MooreCite this: J. Am. Chem. Soc. 1952, 74, 6, 1618Publication Date (Print):March 1, 1952Publication History Published online1 May 2002Published inissue 1 March 1952https://pubs.acs.org/doi/10.1021/ja01126a529https://doi.org/10.1021/ja01126a529research-articleACS PublicationsRequest reuse permissionsArticle Views168Altmetric-Citations44LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Weakly Supervised Object Discovery by Generative Adversarial & Ranking Networks (2019)

The deep generative adversarial networks (GAN) recently have been shown to be promising for different computer vision applications, like image editing, synthesizing high resolution images, generating videos, etc. These networks and the corresponding learning scheme can handle various visual space mappings. We approach GANs with a novel training method and learning objective, to discover multiple object instances for three cases: 1) synthesizing a picture of a specific object within a cluttered scene; 2) localizing different categories in images for weakly supervised object detection; and 3) improving object discovery in object detection pipelines. A crucial advantage of our method is that it learns a new deep similarity metric, to distinguish multiple objects in one image. We demonstrate that the network can act as an encoder-decoder generating parts of an image which contain an object, or as a modified deep CNN to represent images for object detection in supervised and weakly supervised scheme. Our ranking GAN offers a novel way to search through images for object specific patterns. We have conducted experiments for different scenarios and demonstrate the method performance for object synthesizing and weakly supervised object detection and classification using the MS-COCO and PASCAL VOC datasets.