gebhart/patrepeval huggingface dataset:
Cardiac mGluR1 metabotropic receptors in cardioprotection (2017)

This study provides the first demonstration that mGluR1 activation at the onset of reperfusion induces cardioprotection and might represent a putative strategy to prevent ischaemia-reperfusion injury.
Hyperinsulinemia promotes aberrant histone acetylation in triple negative breast cancer (2018)

Abstract Excess levels of insulin relative to glucose in the blood, or hyperinsulinemia, is considered to be a poor prognostic indicator for patients with triple negative breast cancer (TNBC). While this association has been recognized for some time, the mechanistic role of hyperinsulinemia in promoting TNBC remains unclear. We show that insulin treatment leads to genome-wide increase in histone acetylation, in particular at H3K9, through the PI3K/AKT/mTOR pathway in MDA-MB-231 cells. Genome-wide analysis showed that the increase in histone acetylation occurs primarily at gene promoters. In addition, insulin induces higher levels of reactive oxygen species and DNA damage foci in cells. In vivo , hyperinsulinemia also enhances growth of MDA-MB-231 derived tumors through increased histone acetylation. These results demonstrate the impact of hyperinsulinemia on altered gene regulation through chromatin and the importance of targeting hyperinsulinemia-induced processes that lead to chromatin dysfunction in TNBC.
FABRICATION DEVELOPMENT OF APM FUEL ELEMENTS FOR ORGANIC COOLED REACTORS (1961)

Strength at high temperature, high thermal conductivity, neutron absorption, and good corrosion resistance make aluminum powder metallurgy (APM) alloys especially , suitable for cladding and structural materials for organic cooled and moderated reactor fuel elements. Fabrication techniques developed for the APM alloys are described and they include such methods as conventional forging rolling, and extrusion processes The principal properties and the diffusion bonding method for joining the APM alloys are also discussed. (N.W.R.)
Studies of tracheal secretion using serous cell cultures and monoclonal antibodies (1987)

The glycoconjugate composition of tracheal secretions varies with physiological and pathophysiological parameters. Believing that these differences might be explained by metabolic or regulatory modifications of particular cell types, we have developed strategies for biochemical analysis at the cellular level. We have produced monoclonal antibodies whose determinants are restricted to a single secretory cell type (serous, mucous, or goblet cell granules, or ciliated cell glycocalyx). By enzyme immunoassay (ELISA), we have characterized four of the antibodies biochemically, and have also used the antibodies as quantitative molecular probes to detect release of antigen from mixed cell explants. Four of the antigens are carried by carbohydrate moieties of high molecular weight glycoproteins. Western blot analysis shows their molecular weight in reducing gels (SDS-PAGE) to exceed 200 kD. When used in parallel with pulse-chase labeling studies, the antibodies are both more sensitive and specific (than bound radioactivity) in detecting gland or goblet cell secretion in response to autonomic drugs or proteases. We have also isolated and cultured serous gland cells for physiological and biochemical studies. These cells express serous cell phenotype as reflected by ultrastructure, histochemistry, and lysozyme activity. Biochemical analysis of their secretory products reveals glycoconjugate components which are heterogeneous with respect to both molecular weight and charge. Radiolabeled secretory products eluting in the void volume of Sepharose C1 4B were completely degraded by chondroitinase ABC. This indicates that the major glycoconjugate produced by serous cell is a proteoglycan resembling chondroitin sulfate.
MRI of Transplanted Neural Stem Cells (2010)

Stem cell-based therapy has the potential to improve the prospect of patients suffering from many untreatable diseases. Applications of stem cells for therapy of neurological conditions, such as Parkinson's disease, Alzheimer's disease, multiple sclerosis, or stroke, are particularly appealing as damage of the central nervous system is irreversible and the efficacy of conventional therapy is limited. Despite a broad interest among researchers and clinicians, progress in this field has been slow due to the remarkable complexity of the brain, which makes the task of repairing damaged tissue with stem cells extremely challenging. Making advances can be expedited by novel technologies that can monitor transplanted cells non-invasively. In vivo cellular imaging allows for the repetitive, real-time observation of targeted cells over the course of treatment without the need for invasive biopsies. Magnetic resonance imaging (MRI) is an excellent non-invasive cellular imaging modality as it has superior resolution, is widely used clinically, and has no radiation. This technique currently requires magnetic labeling of cells using superparamagnetic iron oxide particles (SPIOs) and transfection agents. In this chapter, methods for cellular labeling with SPIOs, transplantation of stem cells into the mouse brain, and MR imaging of the cells both in vivo and postmortem will be described. Additional histological and immunohistochemical procedures for analysis of the transplanted cells and the diseased brain environment are also provided.
Near-field antenna measurements on a cylindrical surface : (1977)

The theory for probe-corrected measurement of antennas by scanning on a circular cylindrical surface enclosing the test antenna in the near-field is formulated from a source scattering matrix description of the test and probe antennas.
A flexible design of a decision feedback equalizer and a novel CCK technique for wireless LAN systems (2003)

In the wireless mobile communication system, a decision feedback equalizer (DFE) to cancel the inter symbol interference (ISI) is required. This paper analyzes and implements the decision feedback equalizer and a novel CCK architecture of the receiver. All the filters are implemented using the finite impulse response (FIR) filter. The least mean square (LMS) algorithm with initial values is used for updating the coefficient as fast as it can be in the parallel DFE architecture. The area requirement of the novel CCK demodulator structure is about half of that of Fast Walsh Block structure, while their delay times are approximately the same. After synthesis, the total gate counts of the DFE and the CCK demodulator are 58624 and 9937, respectively. The power consumption of DFE is 25.087 mW operating under a 3.3 V supply voltage.
Postweaning Weights and Gains of Cattle Raised under Range and Gain Test Environments2 (1987)

Progeny from an outbred Hereford herd maintained under southwest range conditions were evaluated in two diverse environments. All heifer progeny and a random one-half of the bull progeny from each sire group were retained on the ranch under range conditions until 2 yr of age. The remainder of the bull calves were placed on 140-d postweaning gain test in Tucson. Traits evaluated on the gain test (and heritability estimates ± SE) were initial weight on test (.19 ± .20), final weight off test (.52 ± .24), final body condition score (.07 ± .18) and 140-d gain (.47 ± .23). Traits evaluated on heifer progeny under range conditions (and heritability estimates ± SE) were weights and condition scores at 12 (.42 ± .18 and .02 ± .11), 20 (.29 ± .21 and .17 ± .20) and 24 mo (.24 ± .22 and .07 ± .19), and daily gains from 8 to 12 (.15 ± .14), 12 to 20 (.33 ± .22) 12 to 24 (.17 ± .21) and 20 to 24 mo (.08 ± .21). Gains from 8 to 12 and 20 to 24 mo were negative. Genetic correlations among weights and gains within environments were generally positive. Environmental and phenotypic correlations in the gain test environment also were positive, but were variable in the range environment. The sire × environment interactions were not important sources of variation among weights under range conditions and weights and gain on the gain test. The interactions were significant for gain traits under range conditions when cattle lost or minimally gained weight and for both final weight and 140-d gain on the gain test. Product-moment and rank correlations among estimated breeding values in both environments indicated a low association of sire rankings in the different environments. Selection of heifers for weights under range conditions at 12 or 20 mo should result in favorable indirect responses in weights and gains of half-sib bulls in the gain test environment.
The semantics of future and its use in program optimization (1995)

The future annotations of MultiLisp provide a simple method for taming the implicit parallelism of functional programs. Past research concerning futures has focused on implementation issues. In this paper, we present a series of operational semantics for an idealized functional language with futures with varying degrees of intensionality. We develop a set-based analysis algorithm from the most intensional semantics, and use that algorithm to perform touch optimization on programs. Experiments with the Gambit compiler indicates that this optimization substantially reduces program execution times.
[The nonspecific resistance of the oral cavity in adolescents]. (1991)

Nonspecific resistance of the oral cavity was studied in 83 adolescents with catarrhal gingivitis, generalized or focal periodontitis, and intact periodontium. Mixed salivary and gingival fluid pools were examined. Immunoglobulins A and G, secretory immunoglobulin A, salivary and gingival fluid lysozyme, B lyse activity, and salivary excretion rate were measured. The findings evidence activation of local defense factors in catarrhal gingivitis at the expense of nonspecific defense factors, and a reduction of nonspecific defense parallelled by activation of the specific factors (secretory IgA) in periodontitis, which fact may be explained by augmentation of the antigenic stimulus at the expense of bacterial plaque dissemination under the gingiva.
Abstract P122: Postconditioning to Reduce Infarct Size Following Acute Myocardial Infarction (2009)

BACKGROUND: Postconditioning (PC) is a novel strategy to reduce reperfusion injury following myocardial infarction through graded restoration of blood flow. Cardiac magnetic resonance (CMR) imaging...
Methods for visual quality assessment of a digital terrain model (2009)

A Digital Terrain Model (DTM) is a continuous representation of a ground surface landform that is commonly used to produce topographic maps.DTMs are created by integrating data obtained from a wide range of techniques including remote sensing and land surveying.Quality assessment of data is a critical parameter for DTM production and it relies heavily on statistical methods.In contrast, visual methods are generally neglected despite their potential for improving DTM quality.In this paper, several enhanced visual techniques for quality assessment are described and illustrated with areas and datasets selected from Slovenia and the planet Mars.Four classes of visual methods are defined: visualisations according to spatial analytical operations based on one or multiple datasets; visualisations according to spatial statistical analysis; non-spatial visualisations; and other visualisation techniques/other algorithms.The four classes generate different outputs: the first two produce thematic maps, while the third is used for non-spatial visualisation.The fourth class gathers other possible visualisations and algorithms.It is suggested that applying visual methods in addition to the more objective statistical methods would result in a more efficient improvement of the quality.
Modified Aloe barbadensis Polysaccharide with Immunoregulatory Activity (2000)

Aloe barbadensis polysaccharide was partially digested with cellulase and further purified by dialysis, stepwise ethanol precipitation, and size exclusion chromatography. Crude modified Aloe polysaccharide (MAP) activated macrophage cells and stimulated fibroblast growth. Under the same conditions, native Aloe barbadensis gel had no effect on macrophage activation. MAP prevented ultraviolet B (UVB) irradiation-induced immune suppression as determined by contact hypersensitivity (CHS) response in C3H/HeN mice. This in vivo activity was correlated with the activity of MAP to inhibit UVB irradiation-induced tumor necrosis factor alpha (TNF-alpha) release from human epidermoid carcinoma cells (KB cells). MAP with an average molecular weight of 80,000 Dalton (Da) contained mannose, galactose, and glucose in a ratio of 40:1.4:1.0. MAP was likely a linear, highly acetylated molecule.
Halogenation of Carbonyl and Related Compounds (2018)

Abstract Aldehydes and Ketones Acetals Lactols Carboxylic Acids Acid Halides Esters and Lactones Amides and Lactams Imides and Related Compounds Nitriles
Quasielastic and inelastic neutron scattering on hydrated calcium silicate pastes (2004)

Using the inverse geometry spectrometer QENS at the Intense Pulsed Neutron Source of the Argonne National Laboratory, we collected quasielastic and inelastic neutron scattering spectra of hydrated tricalcium and dicalcium silicate, the main components of ordinary Portland cement. Data were obtained at different curing time, from a few hours to several months. Both the quasielastic and inelastic spectra have been analyzed at the same time according to the relaxing cage model, which is a model developed to describe the dynamics of water at supercooled temperatures. Short-time and long-time dynamics of hydration water in hydrated cement pastes as a function of the curing time have been simultaneously obtained. The results confirm the findings reported in previous experiments showing that it is possible to fit consistently the quasielastic and inelastic spectra giving insights on the effect of the curing time on the short-time vibrational dynamics of hydration water.
Skeletal muscle bioenergetics inthechronic fatigue syndrome (1993)

musclebioenergetics andcon- trolofintracellular pH havebeeninvesti- gatedin46patients withchronic fatigue syndromebyphosphorus magnetic reso- nancespectroscopy. The results have beencomparedwiththosefromhealthy controls andfroma groupofpatients withmitochondrial cytopathies affecting skeletal muscle. Noconsistent abnormal- ities ofglycolysis, mitochondrial metabo- lismorpH regulation wereidentified in the groupwhen takenas a whole, although in12ofthe46patients therela- tionship betweenpH andphosphocrea- tineutilisation duringexercisefell outside thenormalrange.Of these, 6 patients showedincreased acidification relative to phosphocreatine depletion while6 showedreducedacidification. Thesefindings do not supportthe hypothesis thatanyspecific metabolic abnormality underlies fatigue inthissyn- dromealthough abnormalities may be present inaminority ofpatients.
Application of chicken microarrays for gene expression analysis in other avian species (2009)

Cross species hybridisation using long oligonucleotide microarrays is a powerful tool to study the immune response in avian species with little available genomic information. The present study validated the use of the whole genome long oligonucleotide chicken microarray to investigate gene expression in a range of avian species.
Attention deficit disorder in adults. (2002)

ADHD/ADD, once thought to occur only in children, is now recognized as continuing into adulthood in many people. In order to be labeled as such, signs and symptoms must start before age 7 and are primarily characterized by inattention, distractibility, and impulsiveness. Although the exact mechanism is unknown, a number of associated neurochemical and structural abnormalities have been observed. This disorder can negatively affect the educational, social, and occupational lives of those who suffer from its symptoms. It interferes with the ability to establish and maintain close relationships. Pharmacotherapy remains the primary mode of treatment. Stimulants such as dextroamphetamine and methylphenidate are the main drugs utilized; they are available in immediate and longer duration versions. Bupropion is another important medicinal option, and there are a variety of other miscellaneous medications to consider, including modafinil, venlafaxine, tricyclic antidepressants, and guanfacine. Psychotherapy is shown to help control impulsiveness, form more satisfactory relationships, rear children more effectively, and improve organizational and problem-solving skills.
Pancreatogastrostomy Versus Pancreatojejunostomy for RECOnstruction After PANCreatoduodenectomy (RECOPANC, DRKS 00000767) (2015)

The rate of grade B/C fistula after PG versus PJ was not different. There were more postoperative bleeding events with PG. Perioperative morbidity and mortality of pancreatoduodenectomy seem to be underestimated, even in the high-volume center setting.
Liver X receptor-dependent inhibition of microglial nitric oxide synthase 2 (2015)

LXR can be targeted to modulate microglial activation. LXR-dependent repression of inflammatory genes may be stimulus-dependent and impaired by HDAC inhibition. Endogenous LXR activity does not appear to modulate CNS inflammation, but LXR activity can be partially restored in the CNS by administration of exogenous LXR agonist with an impact on clinical disease severity at early, but not late, time points in EAE.
Bone marrow transplantation for acute leukemia: recent advances and comparison with alternative therapies. (1987)

Bone marrow transplantation is an effective therapy in patients with acute leukemia. High-dose chemotherapy with or without total body irradiation and allogeneic bone marrow transplantation is a more effective antileukemic treatment than chemotherapy. This approach is limited, however, by a relatively high risk of transplant-related complications, particularly graft rejection, GVHD, and interstitial pneumonitis. Autologous bone marrow transplantation avoids the problems of graft rejection and GVHD. It does, however, introduce a risk of reinfusing residual leukemia cells with the autologous bone marrow and absence of a possible graft-versus-leukemia effect associated with allogeneic transplants. Bone marrow transplantation is useful in AML. Syngeneic or allogeneic HLA-identical bone marrow transplantation is the preferred treatment for patients under age 45 to 50 who fail chemotherapy. Transplantation is also likely to be superior or comparable to chemotherapy for patients less than 20 to 30 years of age in first remission. Transplantation in older individuals in first remission is controversial; results are comparable to those achieved with postremission chemotherapy. Transplants from donors other than HLA-identical siblings must be considered investigational but may be a reasonable alternative in young individuals in first relapse or second remission. Autotransplants are difficult to evaluate critically but may be considered as investigational therapy for individuals in second or later remission for whom a suitable allogeneic donor is unavailable. Autotransplants in first remission should be restricted to controlled clinical trials because it is otherwise impossible to determine their efficacy. It is uncertain whether ex vivo treatment of the bone marrow to remove leukemia cells is necessary in the context of autotransplantation; again, controlled trials are required. Bone marrow transplantation from an HLA-identical sibling is effective in individuals with ALL who relapse despite chemotherapy. Patients undergoing transplantation while in second or later remission or in relapse have a survival rate superior to those treated with chemotherapy. One important and unresolved issue is whether patients with high-risk ALL should receive bone marrow transplants or intensive postremission chemotherapy while in first remission; controlled clinical trials are needed. Bone marrow transplants from donors other than HLA-identical siblings and autologous bone marrow transplants are investigational approaches that should be considered in selected young patients who fail despite chemotherapy.(ABSTRACT TRUNCATED AT 400 WORDS)
Conceptual modeling and specification generation for B2B business processes based on ebXML (2002)

In order to support dynamic setup of business processes among independent organizations, a formal standard schema for describing the business processes is basically required. The ebXML framework provides such a specification schema called BPSS (Business Process Specification Schema) which is available in two stand-alone representations: a UML version, and an XML version. The former, however, is not intended for the direct creation of business process specifications, but for defining specification elements and their relationships required for creating an ebXML-compliant business process specification. For this reason, it is very important to support conceptual modeling that is well organized and directly matched with major modeling concepts. This paper deals with how to represent and manage B2B business processes using UML-compliant diagrams. The major challenge is to organize UML diagrams in a natural way that is well suited with the business process meta-model and then to transform the diagrams into an XML version. This paper demonstrates the usefulness of conceptually modeling business processes by prototyping a business process editor tool called ebDesigner.
Fission product transport analysis. Quarterly progress report, 1 October--31 December 1977. [TRAP-PWR/BWR code; TRAP-MELT code] (1978)

This is a quarterly progress report about improving the TRAP-PWR/BWR code and performing the sensitivity analyses for terminated LOCA's, and performing thermal-hydraulic analyses of various postulated meltdown accident sequences for BWR's. These calculations were for the purpose of determining ranges of temperatures and flow rates that must be covered by the deposition models being added to the TRAP-MELT code. The results of these two major technical efforts are discussed individually.
Hydraulic Performance of Geosynthetic Clay Liners in a Landfill Final Cover (2007)

Percolation from a landfill final cover containing a geosynthetic clay liner (GCL) as the hydraulic barrier is described. The GCL was covered with 760mm of vegetated silty sand and underlain with two gravel-filled lysimeters to monitor percolation from the base of the cover. Higher than anticipated percolation rates were recorded in both lysimeters within 4–15months after installation of the GCL. The GCL was subsequently replaced with a GCL laminated with a polyethylene geofilm on one surface (a “composite” GCL). The composite GCL was installed in two ways, with the geofilm oriented upwards or downwards. Low percolation rates (2.6–4.1mm∕year) have been transmitted from the composite GCL for more than 5years regardless of the orientation of the geofilm. Samples of the conventional GCL that were exhumed from the cover ultimately had hydraulic conductivities on the order of 5×10−5cm∕s . These high hydraulic conductivities apparently were caused by exchange of Ca and Mg for Na on the bentonite combined with dehydration. The overlying and underlying soils likely were the source of the Ca and Mg involved in the exchange. Column experiments and numerical modeling indicated that plant roots and hydraulic anomalies caused by the lysimeters were not responsible for the high hydraulic conductivity of the GCL. Despite reports by others, the findings of this study indicate that a surface layer 760mm thick is unlikely to protect conventional GCLs from damage caused by cation exchange and dehydration. Accordingly, GCLs should be used in final covers with caution unless if cation exchange and dehydration can be prevented or another barrier layer is present (geomembrane or geofilm).