gebhart/patrepeval huggingface dataset:
Pro-angiogenic Activities of CYR61 (CCN1) Mediated through Integrins αvβ3 and α6β1 in Human Umbilical Vein Endothelial Cells (2002)

CYR61 (CCN1) is an extracellular matrix-associated protein of the CCN family, which also includes CTGF (CCN2), NOV (CCN3), WISP-1 (CCN4), WISP-2 (CCN5), and WISP-3 (CCN6). Purified CYR61 induces neovascularization in corneal implants, and Cyr61-null mice suffer embryonic death due to vascular defects, thus establishing that CYR61 is an important regulator of angiogenesis. Aberrant expression of Cyr61 is associated with breast cancer, wound healing, and vascular diseases such as atherosclerosis and restenosis. In culture, CYR61 functions through integrin-mediated pathways to promote cell adhesion, migration, and proliferation. Here we show that CYR61 can also promote cell survival and tubule formation in human umbilical vein endothelial cells. Furthermore, we have dissected the integrin receptor requirements of CYR61 with respect to its pro-angiogenic activities. Thus, CYR61-induced cell adhesion and tubule formation occur through interaction with integrin alpha(6)beta(1) in early passage endothelial cells in which integrins have not been activated. By contrast, in endothelial cells in which integrins are activated by phorbol ester or vascular endothelial growth factor, CYR61-promoted cell adhesion, migration, survival, growth factor-induced mitogenesis, and endothelial tubule formation are all mediated through integrin alpha(v)beta(3). These findings indicate that CYR61 is an activation-dependent ligand of integrin alpha(v)beta(3) and an activation-independent ligand of integrin alpha(6)beta(1) and that these integrins differentially mediate the pro-angiogenic activities of CYR61. These findings help to define the mechanisms by which CYR61 acts as an angiogenic regulator, provide a molecular interpretation for the loss of vascular integrity and increased apoptosis of vascular cells in Cyr61-null mice, and underscore the importance of CYR61 in the development and homeostasis of the vascular system.
Phytochemical analysis and bioactivity of the aerial parts of Abutilon theophrasti (Malvaceae), a medicinal weed (2014)

Phytochemical investigations of aerial parts of Abutilon theophrasti yielded (6S,9R)-roseoside (1) and (6S,9S)-roseoside (2) which are new for the genus. The elucidation of the chemical structures was established by mass spectrometry, 1D and 2D NMR experiments. Although methanol extracts contained 48.5 ± 7.2 mg of caffeic acid equivalents and 15.87 ± 4.6 mg of quercetin equivalents, the antioxidant activity, as revealed by DPPH and ABTS assays, was of medium strength (EC50 of 306.2 ± 16.3 and 394.3 ± 14.8 μg/mL, respectively). A. theophrasti extract inhibits soybean 5-LOX with IC50 value 2.89 ± 0.2 mg/mL. The cytotoxicity of the methanol extract against MCF-7, CCRF-CEM and CEM/ADR5000 cancer cells resulted in IC50 values of 505.8 ± 34.7 μg/mL for MCF-7, 75.6 ± 7.1 μg/mL for CCRF-CEM, and 89.5 ± 13.4 μg/mL for CEM/ADR 5000 cells.
Introducing the Human Brain Project (2011)

The Human Brain Project (HBP) is a candidate project in the European Union's FET Flagship Program, funded by the ICT Program in the Seventh Framework Program. The project will develop a new integrated strategy for understanding the human brain and a novel research platform that will integrate all the data and knowledge we can acquire about the structure and function of the brain and use it to build unifying models that can be validated by simulations running on supercomputers. The project will drive the development of supercomputing for the life sciences, generate new neuroscientific data as a benchmark for modeling, develop radically new tools for informatics, modeling and simulation, and build virtual laboratories for collaborative basic and clinical studies, drug simulation and virtual prototyping of neuroprosthetic, neuromorphic, and robotic devices.
An asymmetric oligomer based on thienoacene for solution processed crystal organic thin-film transistors (2012)

A novel thienoacene-based conjugated oligomer, i.e.BTTT-T-C12, was designed and synthesized. Its highly asymmetric structural feature enables the preparation of two-dimensional single-crystalline thin films in millimetre size and ~100 nm thick by a solution processing method directly on the Si/SiO(2) substrate. Single crystal organic thin film transistors exhibit a mobility of 0.70 cm(2) V(-1) s(-1) and an on/off ratio of 5.7 × 10(4).
HuBMAP UF TMC - FACS Sorting of Live CD45+ Cells for 10x scRNASeq v1 (2021)

This standard operating procedure (SOP) provides instructions for staining and sorting live cells. This SOP applies to cryopreserved cells that are stained with Live/Dead and sorted in the BD ARIA III to remove dead cells prior to 10x sequencing.
Two forms of gonadotropin-releasing hormone (GnRH) are expressed in human breast tissue and overexpressed in breast cancer: a putative mechanism for the antiproliferative effect of GnRH by down-regulation of acidic ribosomal phosphoproteins P1 and P2. (2002)

Gonadotropin-releasing hormone (GnRH) analogues are used for the treatment of breast, prostate, and ovarian cancer. These analogues exert their antitumor effects indirectly by inhibiting the pituitary-gonadal axis, as well as by direct inhibition of proliferation of human breast cancer cells. However, the molecular mechanisms mediating these direct antiproliferative effects are not fully understood. We found that normal and malignant human breast tissue express two forms of the neuropeptide GnRH. Quantitative reverse transcription-PCR shows that mRNA encoding the GnRH-I and GnRH-II peptides are overexpressed in cancerous versus normal tissues obtained from the same patients. To elucidate the function of these peptides in breast cancer cells, we used the atlas human cDNA expression arrays technology and studied the differentially regulated genes after GnRH treatment of MCF-7 cells. We found that a wide range of GnRH-I or GnRH-II concentrations (0.1-10 nM) inhibit the expression of mRNA encoding the 60S acidic ribosomal phosphoproteins, P1 and P2. These results were confirmed by quantitative reverse transcription-PCR, as well as Western blot analysis and immunofluorescence staining. The P1 and P2 proteins interact with elongation factors EF1 and EF2, and the level of their phosphorylation is one of the regulatory mechanisms for the overall rate of protein elongation. Thus, reduced expression of P1 and P2 proteins can affect the rate of protein translation, thereby decreasing proliferation rate of cells. Our studies may therefore suggest a putative mechanism for the direct antiproliferative effect of GnRH in breast cancer cells.
Theoretical study of the crystal structure, stability, and properties of phases in the V-N system (2021)

Stable compounds in the V-N binary system are systematically investigated and four new phases are found: $Pbam\text{\ensuremath{-}}{\mathrm{V}}_{5}{\mathrm{N}}_{2}, Pnma\text{\ensuremath{-}}{\mathrm{V}}_{2}\mathrm{N}, P\overline{3}m1\text{\ensuremath{-}}{\mathrm{V}}_{2}{\mathrm{N}}_{3}$, and $I4/mcm\text{\ensuremath{-}}{\mathrm{VN}}_{2}$. All the predicted high-pressure vanadium nitrides are dynamically stable at ambient pressure. Moreover, the thermodynamic stability of vanadium nitrides in the temperature range of 0--1500 K at different pressures (0, 20, 40, 60, and 120 GPa) was also evaluated within the harmonic approximation. The sequence of phases of ${\mathrm{V}}_{2}\mathrm{N}$ under pressure is $\ensuremath{\varepsilon}{\text{-Fe}}_{2}\text{N}\phantom{\rule{0.16em}{0ex}}\text{type}\ensuremath{\rightarrow}\ensuremath{\zeta}{\text{-Fe}}_{2}\text{N}\phantom{\rule{0.16em}{0ex}}\text{type}\ensuremath{\rightarrow}{\text{Fe}}_{2}\text{C}\phantom{\rule{0.16em}{0ex}}\text{type}\ensuremath{\rightarrow}Pnma{\text{-V}}_{2}\text{N}$. In addition, relative stability and lattice dynamics properties of several vanadium mononitrides are systematically calculated and discussed. Structural features, mechanical properties, electronic structures, and chemical bonding of all the V-N compounds are analyzed at 0 GPa. Among these vanadium nitrides, WC-type VN has the highest Vickers hardness ($\ensuremath{\sim}37\phantom{\rule{0.16em}{0ex}}\mathrm{GPa}$) and superior fracture toughness (4.3--6.1 MPa ${\mathrm{m}}^{1/2}$), which mainly originate from its strong V-N bonding as well as its strong three-dimensional V-N covalent bond network. The configuration of the strong and short N-N covalent bonds enables the new phase $I4/mcm\text{\ensuremath{-}}{\mathrm{VN}}_{2}$ to exhibit good mechanical properties. Our results also reveal that the formation of a strong covalent-bond network topology in a crystal is a fundamental principle for designing a hard or superhard structure.
Unicompartmental knee replacement: a historical overview. (2015)

There is currently a growing demand for unicompartmental knee replacement (UKR) to treat degenerative osteoarthritis or osteonecrosis of a single compartment of the knee. This procedure has evolved significantly over the past three decades and we here present a brief review of the literature on this topic. This historical overview traces the hypotheses that have led to the modern state of the art in minimally invasive UKR surgery and to the revival of the concept of interpositional hemiarthroplasty.
A Novel Offset-Compensated Low-Level Envelope Detector (1987)

An integrated envelope detector for the linear and accurate detection of amplitude modulated signals at levels as low as 3 mV and frequencies up to 15 MHz is presented. The DC input offset voltage is automatically compensated by using a novel technique. The circuit employs full-wave detection in an accurate biased diode bridge. At an 80% modulation depth, the distortion in the demodulated signal is well below 1%.
Elimination and Nucleophilic Substitution on Nitrogen Atom. Reactions of O-Aroyl-N,N-di(p-substituted benzyl)- and O-Aroyl-N-benzoyl-N-benzylhydroxylamines with Various Nucleophiles in Dipolar Aprotic Solvents (1976)

Abstract The reactions of the title compounds with various nucleophiles were found to proceed through either elimination or nucleophilic substitution on the nitrogen atom depending on both the structure of the substrate and the nature of nucleophiles used. The effect of substituent and the primary isotope effect (kH⁄kD of 7.6 and 8.1 with NaN3 and LiCl at 30 °C) on the elimination of O-(p-nitrobenzoyl)-N,N-dibenzylhydroxylamine revealed that the reaction is an E2 process involving the rate-determining proton abstraction by base and proceeds via an ionic transition state of an ideal concerted type. Nucleophilic substitution on the trivalent nitrogen atom has been inferred for the reactions with such nucleophiles as diethyl sulfide, p-toluenethiol and sodium cyanide on the basis of product distribution.
Genetic algorithm-assisted soft fusion-based linear cooperative spectrum sensing (2011)

In this letter, a cooperative spectrum sensing scheme for cognitive radio networks based on genetic algorithm (GA) is proposed. The proposed scheme lies in optimizing the weighting coefficients vector used in a linear soft-decision fusion- (SDF-) based framework. The detection performance of the proposed GA-assisted SDF-based scheme is compared with the conventional SDF schemes as well as the OR-logic hard-decision fusion (HDF) scheme. The simulation results show that the proposed scheme outperforms all other schemes and can achieve higher probability of detection given the same probability of false alarm.
Des matériaux à mémoire de forme en amidon (2012)

National audience
Anomalous group velocity in a 3D photonic nanostructure (2009)

Experiments have confirmed the existence of both behaviors in three-dimensional ordered nanostructures, in the spectral range where the wavelength of light is on the order, or smaller, than the lattice constant. Using periodic boundary conditions in a band structure calculation of a perfect 3D photonic crystal one finds that, in such frequency range, only propagating modes with a vanishing slope dispersion relation exist and, hence, a reduced group velocity is predicted. In this paper, we study such group velocity behavior for finite thin artificial opal slabs made of a reduced number of layers. In our model extinction is included. The group velocity and group index of the electromagnetic waves from the linear response of the crystal, is determined in the high energy spectral region.
From molecular chaperones to membrane motors: through the lens of a mass spectrometrist (2017)

Twenty-five years ago, we obtained our first mass spectra of molecular chaperones in complex with protein ligands and entered a new field of gas-phase structural biology. It is perhaps now time to pause and reflect, and to ask how many of our initial structure predictions and models derived from mass spectrometry (MS) datasets were correct. With recent advances in structure determination, many of the most challenging complexes that we studied over the years have become tractable by other structural biology approaches enabling such comparisons to be made. Moreover, in the light of powerful new electron microscopy methods, what role is there now for MS? In considering these questions, I will give my personal view on progress and problems as well as my predictions for future directions.
Numerical Simulation of RF Heating for a SIC Vapor Growth System (2001)

Abstract A numerical model has been developed to calculate the magnetic potential and temperature distribution in a RF heating system used for a SiC vapor growth system. The magnetic vector potential is calculated by solving the Maxwell equations. The heating power generated in the graphite susceptor is obtained using the Joules law. The temperature profile in a growth chamber is then calculated by solving the energy transport equation with induction heat as a source term. Two sets of grid system have been used to speed up the calculation. The frequency of RF heating and coil current are found to have significant impact on heat generation and its distribution in the graphite susceptor. The maximum temperature in the crucible has a linear relationship with the input power; however, the power input does not influence significantly the temperature gradient. To optimize the heating system for a SiC vapor growth system, the current, frequency, and geometry need to be carefully designed.
Prospective Evaluation of Structural Allograft Transplantation for Osteochondral Lesions of the Talar Shoulder (2017)

Level IV, prospective case series.
Resilience of Delay-Sensitive Services With Transport-Layer Monitoring in SD-WAN (2022)

Today, more and more enterprises are embarking on a digital transformation where most of their applications are hosted in the Cloud. As a result, a reliable Wide Area Network (WAN) has become a primary need to interconnect their distributed branch offices and data centers that accommodate those applications. Software-Defined Wide Area Network (SD-WAN) represents the most promising technology solution for next-generation enterprise networks, being able to increase network agility and reduce costs. In this paper, we present an experimental SD-WAN solution capable of running and optimizing delay-sensitive high-priority services, such as real-time video streaming, while minimizing downtime caused by network failures. This solution comprises a monitoring and a traffic engineering system for SD-WAN. The first consists of a Transport-layer Passive Monitoring (TPM) system based on extended Berkeley Packet Filter (eBPF) technology with the goal of monitoring TCP flows; the second consists of an application, running inside the SD-WAN controller, with the goal of orchestrating the network traffic in consideration of the monitoring measurements by ensuring rapid recovery and resilience in case of unexpected congestion events. We validate our solution over two SD-WAN testbeds: the first is hosted in our laboratory at Politecnico di Milano, while the second is deployed in a municipal network of an Italian city. Results show that our SD-WAN solution can increase the overall service availability while meeting the stringent QoS requirements of delay-sensitive services.s
Des flottants 16 bits sur microprocesseurs d'usage général pour images et multimédia (2005)

We consider the implementation of 16-bit floating point instructions on a Pentium 4 and a PowerPC G5 for image and media processing. By measuring the execution time of bench-marks with these new simulated instructions, we show that significant speed-ups are obtained compared to 32-bit FP versions. For image processing, the speed-up both comes from doubling the number ofoperations per SIMD instruction and the better cache behavior with byte storage. For data stream processing with arrays of structures, the speed-up comes from the wider SIMD instructions.
Waveguide and radiation applications of modes in linear chains of plasmonic nanospheres (2013)

We apply an analytical procedure that uses a periodic Green's function based on the Ewald representation to compute the modes in a linear chain of plasmonic nanospheres, including the case of complex modal wave numbers. We analyze both transverse and longitudinal polarizations (with respect to the array axis) of the nanospheres' electric dipole moments. Among all the modes, we discuss those excitable and that can be used for wave guidance through bound modes or for radiation through leaky modes. © 2013 IEICE.
States of Terror: History, Theory, Literature (2019)

How have we come to depend so greatly on the words terror and terrorism to describe broad categories of violence? David Simpson offers here a philology of terror, tracking the concept's long, complicated history across literature, philosophy, political science, and theology-from Plato to NATO. Introducing the concept of the "fear-terror cluster," Simpson is able to capture the wide range of terms that we have used to express extreme emotional states over the centuries-from anxiety, awe, and concern to dread, fear, and horror. He shows that the choices we make among such words to describe shades of feeling have seriously shaped the attribution of motives, causes, and effects of the word "terror" today, particularly when violence is deployed by or against the state. At a time when terror-talk is widely and damagingly exploited by politicians and the media, this book unpacks the slippery rhetoric of terror and will prove a vital resource across humanistic and social sciences disciplines
Design of reconfigurable slot antennas (2005)

In this paper the design of a compact, efficient and electronically tunable antenna is presented. A single-fed resonant slot loaded with a series of PIN diode switches constitute the fundamental structure of the antenna. The antenna tuning is realized by changing its effective electrical length, which is controlled by the bias voltages of the solid state shunt switches along the slot antenna. Although the design is based on a resonant configuration, an effective bandwidth of 1.7:1 is obtained through this tuning without requiring a reconfigurable matching network. Four resonant frequencies from 540-890 MHz are selected in this bandwidth and very good matching is achieved for all resonant frequencies. Theoretical and experimental behavior of the antenna parameters is presented and it is demonstrated that the radiation pattern, efficiency and polarization state of the antenna remain essentially unaffected by the frequency tuning
Effective Work Function Shift Induced by TiN Sacrificial Metal Gates as a Function of Their Thickness and Composition in 14nm NMOS devices (2014)

2014 International Conference on Solid State Devices and Materials,Effective Work Function Shift Induced by TiN Sacrificial Metal Gates as a Function of Their Thickness and Composition in 14nm NMOS devices
Makef22: An ADCIRC Model Fort.22 Input File Creation Tool for Surface Wind and Pressure Forcing (2007)

Abstract : The User's Manual for the Makef22 software tool, makef22.pl, contains descriptions of the software, including its functionality and usage. The Makef22 software is a Perl-based program that creates an ADvanced CIRCulation (ADCIRC) Model Surface Wind and Pressure Forcing file (fort.22) using the NWS=2 option. The software was developed for ADCIRC version 45.11. In addition to the creation of fort.22 files, the Makef22 utility also can read and process an existing fort.22 file in order to (1) elongate the record either by adding zero valued records at the beginning of the fort.22 file or by repeating the first time record a specified number of times, and/or (2) ramp a specified portion of the fort.22 records from zero to full-scale values. This utility was designed so that readers for new data sources can easily be developed and incorporated into the Makef22 utility. Surface wind and pressure data sources on rectangular, regular grids at known times are read and interpolated onto an ADCIRC finite element mesh (FEM) at user-specified times. The results can be stored in an ASCII text, ADCIRC model specific, fort.22 forcing file.
<title>Optical enhancements of joint-Fourier-transform correlator by image subtraction</title> (1991)

The performance of the joint Fourier transform correlation (JFTC) algorithm is improved by enhancing the frequency domain horizontal edges for the case where the reference and input scene are in the lower half and upper half, respectively, of the space domain. The enhancement of frequency domain horizontal edges eliminates any vertical edges which corresponds to cross correlation between objects in the input scene. Consequently the correlation peak intensity between similar objects is increased and the cross correlation peaks are reduced.
Clinical utility of insulin-like growth factor assays. (1987)

Insulin-like growth I and II (IGF-I and II) mediate many of the peripheral mitogenic actions of growth hormone (GH). The marked dependence of IGF levels on GH adequacy has led to the development of commercial immunoassays for IGF-I (somatomedin-C), and the widespread use of IGF-I levels in the evaluation of short stature. Proper interpretation of IGF-I levels requires consideration of assay methodology, age-related norms, clinical findings, nutritional status, and concurrent hormonal and disease processes. IGF-I levels alone cannot be used to predict stimulated GH response, but may have value in directing the clinical evaluation of a child with short stature. Low IGF-I levels may also be characteristic of a subpopulation of short children with neurosecretory GH deficiency. The role of IGF-II levels in the evaluation of short stature is uncertain, although the combination of low IGF-I and IGF-II levels is more specific for GH deficiency than either value alone. Other clinical applications for IGF assays in pediatrics are also reviewed.
Effects of PEG-PLA-nano Artificial Cells Containing Hemoglobin on Kidney Function and Renal Histology in Rats (2008)

This study is to investigate the long-term effects of PEG-PLA nano artificial cells containing hemoglobin (NanoRBC) on renal function and renal histology after 1/3 blood volume top loading in rats. The experimental rats received one of the following infusions: NanoRBC in Ringer lactate, Ringer lactate, stroma-free hemoglobin (SFHB), polyhemoglobin (PolyHb), autologous rat whole blood (rat RBC). Blood samples were taken before infusions and on days 1, 7 and 21 after infusions for biochemistry analysis. Rats were sacrificed on day 21 after infusions and kidneys were excised for histology examination. Infusion of SFHB induced significant decrease in renal function damage evidenced by elevated serum urea, creatinine and uric acid throughout the 21 days. Kidney histology in SFHb infusion group revealed focal tubular necrosis and intraluminal cellular debris in the proximal tubules, whereas the glomeruli were not observed damaged. In all the other groups, NanoRBC, PolyHb, Ringer lactate and rat RBC, there were no abnormalities in renal biochemistry or histology. In conclusion, injection of NanoRBC did not have adverse effects on renal function nor renal histology.