gebhart/patrepeval huggingface dataset:
Cognitive Chance Discovery (2014)

In this paper, first the author reviews the basic theories--- concept and computational realization of abduction. Then the author briefly reviews chance discovery which focuses on rare and novel events. In addition the author briefly reviews the concept of affordance proposed by Gibson. By using the above concepts and techniques, a dementia care system inspired by affordance is proposed and discussed. Finally the author introduces chance discovery based curation proposed by the author. The dementia care system is discussed from the aspect of communication and chance discovery based curation.
Analysis of alternative signaling pathways of endoderm induction of human embryonic stem cells identifies context specific differences (2012)

Use of FGF2, WNT3A or PI3K inhibition with high activin A may serve well in definitive endoderm induction followed by WNT3A specific signaling to direct the definitive endoderm into late endodermal lineages. Other combinations, though still feasible for endoderm induction, appear less promising for pancreatic endoderm specification in our experiments.
SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 regulates the NF-κB pathway (2018)

Sirtuins are NAD<sup>+</sup>-dependent deacetylases that facilitate cellular stress response. They include SirT6, which protects genome stability and regulates metabolic homeostasis through gene silencing, and whose loss induces an accelerated aging phenotype directly linked to hyperactivation of the NF-κB pathway. Here we show that SirT6 binds to the H3K9me3-specific histone methyltransferase Suv39h1 and induces monoubiquitination of conserved cysteines in the PRE-SET domain of Suv39h1. Following activation of NF-κB signaling Suv39h1 is released from the IκBα locus, subsequently repressing the NF-κB pathway. We propose that SirT6 attenuates the NF-κB pathway through IκBα upregulation via cysteine monoubiquitination and chromatin eviction of Suv39h1. We suggest a mechanism based on SirT6-mediated enhancement of a negative feedback loop that restricts the NF-κB pathway.
Using drug scheduling to manage adverse events associated with hedgehog pathway inhibitors for basal cell carcinoma (2021)

Basal cell carcinoma (BCC) is the most common malignancy and form of skin cancer worldwide; advanced BCC, either as locally advanced BCC (laBCC) or metastatic BCC (mBCC), can cause substantial tissue invasion and morbidity. Until the recent availability of the hedgehog pathway inhibitors (HHIs) sonidegib and vismodegib, treatment options for advanced BCC were limited. These agents demonstrate efficacy in patients with laBCC and mBCC; however, the adverse events (AEs) associated with these agents can lead to treatment interruption or discontinuation and reduced quality of life, all of which significantly impact long-term adherence to therapy, which might affect clinical outcome. Given that most AEs are class-related effects, switching HHIs does not appear to lead to a significantly different AE profile, underscoring the importance of maintaining patients on their first HHI. Interrupting treatment of sonidegib and vismodegib does not appear to undermine the efficacy of these agents and is therefore a practical option to manage AEs in order to maintain continued treatment and disease control.
Using Digital Measurement–Based Care to Address Symptoms of Inattention, Hyperactivity, and Opposition in Youth: Retrospective Analysis of Bend Health (2023)

This study offers promising early evidence that collaborative care DHMIs may facilitate improvements in ADHD symptoms among children and adolescents, addressing the growing need for accessible and high-quality care for behavioral health problems in the United States. However, additional follow-up studies bolstered by larger samples and control groups are necessary to further establish the robustness of these findings.
Assessment of Combustion Characteristics of Higher Alcohols in a Direct Injection Spark Ignition Engine (2013)

The U.S. Renewable Fuel Standard requires an increase in the production of ethanol and advanced biofuels up to 36 billion gallons by 2022. Ethanol will be limited to 15 billion gallons, which leaves 21 billion gallons to come from other sources. Due to its high octane number, renewable character, and minimal toxicity, ethanol was believed to be one of the most favorable alternative fuels to displace gasoline in spark ignition engines. Replacing gasoline with ethanol results in a substantial reduction in vehicle range, and high ethanol content blends can cause material compatibility issues and require adaptive engine calibrations. In addition, ethanol is fully miscible in water which requires blending at distribution sites instead of the refinery. Higher carbon number alcohols, on the other hand, have a higher energy density and lower affinity for water than ethanol, which could mitigate some of the above mentioned issues. However, little information is available on the combustion characteristics of a majority of the longer-chain alcohols. This study evaluates the combustion properties of higher carbon number alcohols, ranging from ethanol (C2) to hexanol (C6) in a direct-injection, spark-ignition engine. Test fuels are created by splash blending alcohols at a volumetric concentration of 50% with a blendstock for oxygenate blending. Combustion characteristics are evaluated by comparing overall efficiencies as well as heat release characteristics and emissions for a set of representative steady-state operating points. Results suggest that combustion properties of blends of alcohols with carbon numbers from two to six are similar to those of the reference fuel at low and medium engine loads. Properties of blends of alcohols with carbon numbers from two to four are similar to those of the reference fuel even at high loads. However, due to their reduced knock resistance, the suitability of longer chain alcohols, specifically C5 and longer, as blending agents at increased levels is questionable.
An electrochemical immunosensor using p-aminophenol redox cycling by NADH on a self-assembled monolayer and ferrocene-modified Au electrodes (2008)

Redox cycling of enzymatically amplified electroactive species has been widely employed for high signal amplification in electrochemical biosensors. However, gold (Au) electrodes are not generally suitable for redox cycling using a reducing (or oxidizing) agent because of the high background current caused by the redox reaction of the agent at highly electrocatalytic Au electrodes. Here we report a new redox cycling scheme, using nicotinamide adenine dinucleotide (NADH), which can be applied to Au electrodes. Importantly, p-aminophenol (AP) redox cycling by NADH is achieved in the absence of diaphorase enzyme. The Au electrodes are modified with a mixed self-assembled monolayer of mercaptododecanoic acid and mercaptoundecanol, and a partially ferrocenyl-tethered dendrimer layer. The self-assembled monolayer of long thiol molecules significantly decreases the background current of the modified Au electrodes, and the ferrocene modification facilitates easy oxidation of AP. The low amount of ferrocene on the Au electrodes minimizes ferrocene-mediated oxidation of NADH. In sandwich-type electrochemical immunosensors for mouse immunoglobulin G (IgG), an alkaline phosphatase label converts p-aminophenylphosphate (APP) into electroactive AP. The amplified AP is oxidized to p-quinoneimine (QI) by electrochemically generated ferrocenium ion. NADH reduces QI back to AP, which can be re-oxidized. This redox cycling enables a low detection limit for mouse IgG (1 pg mL(-1)) to be obtained.
Highly selective and rapidly activatable fluorogenic Thrombin sensors and application in human lung tissue (2017)

A library of FRET-based peptides were prepared and studied as Thrombin substrates. This identified probes that showed selective activation by Thrombin, low fluorescent background signals, stability to Factor Xa, matrix metalloproteases, and primary human inflammatory cell lysates and supernatant. These were selected for further optimization, creating a second generation of fluorogenic probes with improved solubility and Plasmin resistance. The optimised probe allowed the detection of Thrombin activity in ex vivo fibrotic human tissue.
Concrete-Plated Wooden Shear Walls: Structural Details, Testing, and Seismic Characterization (2015)

This paper discusses the structural characterization of a novel hybrid shear-wall system formed by coupling standard platform-frame panels with an external reinforced concrete shelter formed of precast slabs screwed to the wooden frames. The external RC skin is intended as a supplementary bracing system, increasing strength and dissipative capacity of the bare timber frame. The structural performance of such hybrid shear wall under monotonic and cyclic loading was first theorized analytically on the basis of code provisions and then confirmed via experimental tests. The novel shear walls demonstrated to fulfill the requirements prescribed by Eurocode 8. In particular, the analyzed system belongs to high ductility class (HDC). Finally the seismic response of a reference building realized with the innovative hybrid shear walls was simulated by means of a numerical model validated on experimental tests; the suitable behavior factor for the building was estimated.
New Recording Method Combining Thermo-Magnetic Writing and Flux Detection (1999)

We have developed a new perpendicular thermo-magnetic recording method coupled with magnetic flux detection. The resolution is substantially improved by flux detection. Compared to the latest magneto-optical disk drives, the carrier-to-noise ratio of a reproduced signal is 5 dB higher, and the recording density reaches 8.3 Gbit/inch 2 . Moreover, this recording method has a good affinity to near-field optics, and it is an effective technique for attaining a higher density beyond the super-paramagnetic limitation in longitudinal magnetic recording.
Six-Coordinate Ruthenium(II) Complexes Containing Unsymmetrical 1,2-Bis(phosphanyl)ethanes and 1-Arsanyl-2-phosphanylethanes as Ligands (2000)

The bis(η3-2-methallyl)ruthenium(II) complexes [Ru(η3-2-MeC3H4)2(κ2-Ph2PCH2CH2PR2)] [R = iPr (2), Cy (3)] were prepared from the cycloocta-1,5-diene derivative [Ru(η3-2-MeC3H4)2(η4-C8H12)] (1) and the unsymmetrical 1,2-bis(phosphanyl)ethanes Ph2PCH2CH2PR2. The As,P analogue [Ru(η3-2-MeC3H4)2(κ2-Ph2PCH2CH2AstBu2)] (4) was obtained by the same route. The reaction of 2 with hexafluoroacetylacetone afforded the chelate compound [Ru(κ2-[F6]acac)2(κ2-iPr2PCH2CH2PPh2)], whereas treatment of 2 and 3 with pentachlorophenol gave the related, more labile complexes [Ru(κ2-O,Cl-OC6Cl5)2(κ2-R2PCH2CH2PPh2)] [R = iPr (6), Cy (7)]. Preparation of the parent bis(acac) compound [Ru(κ2-acac)2(κ2-iPr2PCH2CH2PPh2)] (8), which could not be obtained from 2 and acacH, was achieved by ligand exchange of 6 and acetylacetone. The molecular structures of 2 and 6 were determined by X-ray crystallography.
Diverse AvrPtoB Homologs from SeveralPseudomonas syringaePathovars Elicit Pto-Dependent Resistance and Have Similar Virulence Activities (2006)

AvrPtoB is a type III effector protein from Pseudomonas syringae pv. tomato that physically interacts with the tomato Pto kinase and, depending on the host genotype, either elicits or suppresses programmed cell death associated with plant immunity. We reported previously that avrPtoB-related sequences are present in diverse gram-negative phytopathogenic bacteria. Here we describe characterization of avrPtoB homologs from P. syringae pv. tomato T1, PT23, and JL1065, P. syringae pv. syringae B728a, and P. syringae pv. maculicola ES4326. The avrPtoB homolog from P. syringae pv. maculicola, hopPmaL, was identified previously. The four new genes identified in this study are designated avrPtoB(T1), avrPtoB(PT23), avrPtoB(JL1065), and avrPtoB(B728a). The AvrPtoB homologs exhibit 52 to 66% amino acid identity with AvrPtoB. Transcripts of each of the avrPtoB homologs were detected in the Pseudomonas strains from which they were isolated. Proteins encoded by the homologs were detected in all strains except P. syringae pv. tomato T1, suggesting that T1 suppresses accumulation of AvrPtoB(T1). All of the homologs interacted with the Pto kinase in a yeast two-hybrid system and elicited a Pto-dependent defense response when they were delivered into leaf cells by DC3000DeltaavrPtoDeltaavrPtoB, a P. syringae pv. tomato strain with a deletion of both avrPto and avrPtoB. Like AvrPtoB, all of the homologs enhanced the ability of DC3000DeltaavrPtoDeltaavrPtoB to form lesions on leaves of two susceptible tomato lines. With the exception of HopPmaL which lacks the C-terminal domain, all AvrPtoB homologs suppressed programmed cell death elicited by the AvrPto-Pto interaction in an Agrobacterium-mediated transient assay. Thus, despite their divergent sequences, AvrPtoB homologs from diverse P. syringae pathovars have conserved avirulence and virulence activities similar to AvrPtoB activity.
Inter-Organizational Knowledge Flow and Innovation Diffusion in Project-Based Industries (2005)

Project-based industries are among the largest industries in the global economy. Innovation research to date, however, has largely focused on traditional, hierarchical industries. When project-based industries are included in innovation studies, the analyses rarely explore the implications of organizational and industry structure on diffusion. A review of the literature on innovation in the project-based construction, motion picture, pharmaceutical, biotechnology, and healthcare industries suggests that organizing around projects creates difficulties for innovation. The extra effort required to diffuse some innovations leads to an innovation gap for project-based industries. A closer examination of the scope of an innovation and the inter-organizational flow of knowledge holds the key to understanding this innovation gap. In this paper we explore the impact of innovation scope and inter-organizational knowledge flows in the residential building industry based on case evidence of wall system innovations.
Autonomous Two-Tier Cloud-Based Demand Side Management Approach with Microgrid (2016)

Demand side management (DSM) is an important application of the future smart grid. DSM programs allow consumers to participate in the operation of the electric grid by reducing or shifting their electricity usage during peak periods. Therefore, in this paper, we propose a two-tier cloud-based DSM to control the residential load of customers equipped with local power generation and storage facilities as auxiliary sources of energy. We consider a power system consisting of multiple regions and equipped with a number of microgrids. In each region, an edge cloud is utilized to find the optimal power consumption schedule for customer appliances in that region. We propose a two-level optimization algorithm with a linear multilevel cost function. At the edge cloud, the power consumption level of local storage and the amount of power being demanded from both local storage facilities and power grid are scheduled by using a bi-level optimization approach. The core cloud then gathers information of the total demand from consumers in different Regions and finds the optimal power consumption schedule for each microgrid in the power system. Simulation results show that the proposed model reduces consumption cost for the customers and improves the power grid in terms of peak load and peak-to-average load ratio.
Dipolar Biexcitons in Lateral Traps in Si/SiGe/Si Heterostructures (2018)

Si/Si1–xGex/Si heterostructures with large-scale (micrometer-size) lateral potential fluctuations at the upper SiGe/Si-cap heterointerface are grown. These potential fluctuations are caused by partial strain relaxation in the SiGe layer. Low-temperature photoluminescence (PL) spectra show that these fluctuations form lateral traps where photoexcited nonequilibrium charge carriers are accumulated and bind into dipolar excitons, which ultimately recombine. At temperatures below 6 K, a new narrow line with a width considerably less than that of the dipolar exciton PL line emerges in the spectra as the level of excitation increases. It is shown that this line is associated with the recombination of dipolar biexcitons in large-scale traps.
Heritable Characters of Maize\nII.-Pistillate Flowered Maize Plants (1920)

In the "freak"\nclass at the Annual\nCorn Show held at Lincoln, Nebraska,\nin the winter of 1913-14,\nthere was exhibited a corn tassel\nwith a heavy setting of seeds. A few\nseeds are not infrequently found in the\nstaminate inflorescence of maize, particularly\nin pod com, and tillers of various\ncorn varieties often end in ears instead\nof in tassels or have tassels, the central\nspikes of which are ear like. The freak\nexhibited at the com show, however,\nwas a large. much branched affair.\nwholly tassel-like in form except for the\nfact that it bore a heavy crop of seed\nlike. a well-filled head of broom corn\nor sorghum. It retained no indication\nof having had any staminate flowers. It\nwas apparently a wholly pistillate inflorescence,\nthough tassel-like in form.
AIR QUALITY AND EMISSION MEASUREMENT METHODOLOGY AT SWINE FINISHING BUILDINGS (2001)

Reliable measurements of air quality and emissions at large livestock buildings with inherently large spatial andtemporal variations of pollutant concentrations are relatively difficult and expensive. Appropriate methodologies for suchmeasurements are not readily apparent and techniques and strategies vary widely. Several important technical issues needto be addressed by an air pollutant emission measurement plan. This article describes comprehensive field measurements ofindoor air quality and air pollutant emissions at eight commercial swine finishing buildings.<br><br>The objective of the field test was to evaluate the effect of a manure additive on concentration and emission of ammonia,hydrogen sulfide, and odor. Continuous measurements of gases, ventilation rate, building static pressure, inside and outsidetemperature and humidity, and wind speed and direction were conducted at four naturallyventilated buildings and fourmechanicallyventilated buildings. Air was pumped continuously from inside each building into airsampling manifolds. Oneair stream was drawn from beneath the floor to assess pit headspace air concentrations. Another air stream was drawn fromventilation exhaust points to assess inside gas concentrations and building emission rates. Gas analyzers were switchedbetween sampling manifolds on 10 to 15min sampling intervals. Ammonia was measured with chemiluminescence NOxanalyzers after conversion to nitric oxide. Hydrogen sulfide was converted to sulfur dioxide and measured withpulsedfluorescence, sulfur dioxide analyzers. Odor samples were collected in bags and evaluated using olfactometry. Gasand odor emission rates were determined by multiplying mean gas concentrations in the exhaust air by ventilation airflowrates. Ventilation rates of naturallyventilated buildings were estimated using sensible heat and carbon dioxide balances.Ventilation rates of mechanicallyventilated buildings were determined by monitoring wall fan operation and directlymeasuring airflow of some variablespeed pit fans with fullsize impeller anemometers. Labor and equipment requirements,pitfalls, problems, and solutions to problems of field studies are discussed. Several recommendations for future studies of thistype were developed based on experience gained during this measurement campaign.
A randomized comparative evaluation of clinical and home application to investigate the effectiveness of silver nitrate (AgNO3) (95%) for the treatment of verruca pedis (2017)

Silver nitrate has been shown to be a safe and effective treatment for verruca pedis, with equal success rates when compared between home and clinical applications.
Temperature-dependent studies of solvated electrons in liquid water with two and three femtosecond pulse sequences (2002)

Two and three pulse sequences with an experimental time resolution of about 100 fs have been used to unravel the dynamics of solvated electrons in water at different temperatures. Both, geminate recombination and relaxation of the absorption spectrum can be distinguished using these pulse sequences. The relaxation process has been analysed applying shape stability of the absorption spectrum on an ultrafast time scale. A rigorous analysis of our data leads to strong evidence that solvated electrons in pure water are formed, after a delay, within the first few hundred fs after 9.32 eV photon absorption. Transferring optical sum rules (moment analysis of the absorption spectrum) to the ultrafast dynamics of solvated electrons we conclude that electronic ground state dynamics dominate the relaxation of solvated electrons.
Crystal Structure of von Willebrand Factor A1 Domain Complexed with Snake Venom, Bitiscetin (2003)

Bitiscetin, a platelet adhesion inducer isolated from venom of the snake Bitis arietans, activates the binding of the von Willebrand factor (VWF) A1 domain to glycoprotein Ib (GPIb) in vitro. This activation requires the formation of a bitiscetin-VWF A1 complex, suggesting an allosteric mechanism of action. Here, we report the crystal structure of bitiscetin-VWF A1 domain complex solved at 2.85 A. In the complex structure, helix alpha5 of VWF A1 domain lies on a concave depression on bitiscetin, and binding sites are located at both ends of the depression. The binding sites correspond well with those proposed previously based on alanine-scanning mutagenesis (Matsui, T., Hamako, J., Matsushita, T., Nakayama, T., Fujimura, Y., and Titani, K. (2002) Biochemistry 41, 7939-7946). Against our expectations, the structure of the VWF A1 domain bound to bitiscetin does not differ significantly from the structure of the free A1 domain. These results are similar to the case of botrocetin, another snake-derived inducer of platelet aggregation, although the binding modes of botrocetin and bitiscetin are different. The modeled structure of the ternary bitiscetin-VWF A1-GPIb complex suggests that an electropositive surface of bitiscetin may interact with a favorably positioned anionic region of GPIb. These results suggest that snake venom proteins induce VWF A1-GPIbalpha binding by interacting with both proteins, and not by causing conformational changes in VWF A1.
The temporal foliar transcriptome of the perennial C3 desert plant Rhazya stricta in its natural environment (2014)

This study shows that temporal profiling is essential to assess the significance of genes apparently responsive to abiotic stress. This revealed that in R. stricta, the circadian clock is a major regulator of DE genes, even of those annotated as stress-responsive in other species. This may be an important feature of the adaptation of R. stricta to its extreme but predictable environment. However, the majority of DE genes were not circadian-regulated. Of these, some were common to other desert species and others were distinct to R. stricta, suggesting that they are important for the adaptation of such plants to arid environments.