gebhart/patrepeval huggingface dataset:
High-Precision Anchored Accumulators for Reproducible Floating-Point Summation (2018)

This paper introduces a new datatype, the High-Precision Anchored (HPA) number, that allows reproducible accumulation of floating-point (FP) numbers in a programmer-selectable range. The new datatype has a larger significand and a smaller range than existing FP formats and has much better arithmetic and computational properties. In particular, it is associative, parallelizable, reproducible and correct. The paper also describes how HPA processing can be implemented as part of Arm's new Scalable Vector Extension (SVE) together with proposals for new instructions aimed specifically at the new datatype. For the modest ranges that will accommodate most problems, HPA processing is much faster than FP arithmetic: performance modelling shows 2-lane HPA accumulation of FP64 operands is 9.5 times faster on Arm's new vector architecture than double double accumulation and accelerates a recently published software algorithm for 3-lane reproducible FP summation by a factor of 5.6. This paper also discusses instruction-level optimizations for FP32 and FP16 summations that further increase HPA performance relative to FP64 accumulations.
S3013 THE VALUE OF THE SWEDISH NATIONAL THR REGISTER – IMPROVED QUALITY AND SIGNIFICANT COST REDUCTION (2004)

Aims: In 1979 a national observation study of total hip arthroplasties was started in Sweden. The Swedish Hip Register describes the epidemiology of primary and revision surgery and identifies risk factors for failure. Every unit reports details concerning implants, surgical and cementing technique and revision procedures online via the Internet home page (www.jru.orthop.gu.se). Methods: Currently the register contains 203 625 primary total hip arthroplasties performed during 1979–2001 and 18 067 revision procedures. Revision is the failure endpoint definition and modified Kaplan-Meier statistics and Poisson models are used for survival analysis. Each hospital receive their results annually providing a system for continuous improvement. Results: The results show that serious complications have declined significantly despite an increasing number of patients at risk. The revision burden for cemented THR (94% of the implants are cemented) is only 7.5%, which is much lower than in other countries. Over the 22 year period revision for aseptic loosening has been reduced to one quarter. Demographics are important since male gender and young age significantly increase the risk for revision. Cementless implants have in general had a worse outcome than expected but improved during the last decade. Conclusion: Problem areas are the young population and revision surgery which must be improved. The revision burden is about two times higher in all other countries. This finding implies that the register is extremely cost-effective and the reduction in direct costs for the health care service in Sweden corresponds to approximately USD 140 millions over the last ten years.
Development of Clinical Prediction Models for Surgery and Complications in Crohn’s Disease (2017)

Separate risk prediction models for Crohn's disease-related surgery and complications were developed using clinical trial data involving community gastroenterology practices. These models could be used to guide Crohn's disease management. External validation is warranted.
Contrasting roles of donor and recipient TGFB1 and IFNG gene polymorphic variants in chronic kidney transplant rejection (2011)

Our results highlight the importance of TGFB1 genotyping in donors, and indicate that polymorphisms in the gene of this cytokine in donor cells might contribute to the development of chronic allograft nephropathy.
Attenuation of Low Frequency Structurally Radiated Noise With an Array of Weak Radiating Cells (1998)

The concept of a weak sound radiating cell is proposed to reduce the low frequency radiated noise from structures. The cell consists of two coupled surfaces such that, when placed on a vibrating structure, the responses of the two surfaces are nearly out-of-phase and of equal strength over a wide frequency range. This structure response leads the cell to behave as an acoustic dipole and thus as a poor sound radiating source. The control of low frequency structurally radiated noise is then achieved by covering the structure with an array of these weak radiating cells, i.e. surface treatment. Thus, the surface treatment essentially transforms the response of the structure to that of a distributed array of dipoles yielding a low sound radiating structure. Theoretical models are developed to predict the performance of the cell. Experimental verification is performed for a single cell applied to a piston-like structure to demonstrate the concept on a simple radiating structure. The results demonstrated an overall sound power level reduction of 5.2 dB between 400-1600 Hz with maximum reductions over 30 dB at discrete frequencies. Finally, an array of weak radiating cells is experimentally applied to a more complex structure, a rectangular plate. The results of the plate experiments reveal an overall sound power level reduction of 10.2 dB between 100-1600 Hz with maximum reductions of 25 dB at discrete frequencies. These results demonstrate the potential of the weak radiating cell concept to reduce low frequency structurally radiated noise.
The Role of Domain Knowledge in Automating Medical Text Report Classification (2003)

For medical text report classification, expert knowledge acquisition is more significant to performance and more cost-effective to obtain than knowledge discovery. Building classifiers should therefore focus more on acquiring knowledge from experts than trying to learn this knowledge inductively.
Perlecan controls neurogenesis in the developing telencephalon (2007)

As a component of the basal lamina, perlecan both maintains this structure and controls the response of the neuroepithelium to growth factors. Less mitotic cells in the early medial ganglionic eminences, and impaired cell cycle progression in the late neocortex, suggests insufficient recruitment and signaling by neurogenic morphogens, such as SHH or FGF2.
Efficient Learning of Distributed Linear-Quadratic Controllers (2019)

In this work, we propose a robust approach to design distributed controllers for unknown-but-sparse linear and time-invariant systems. By leveraging modern techniques in distributed controller synthesis and structured linear inverse problems as applied to system identification, we show that near-optimal distributed controllers can be learned with sub-linear sample complexity and computed with near-linear time complexity, both measured with respect to the dimension of the system. In particular, we provide sharp end-to-end guarantees on the stability and the performance of the designed distributed controller and prove that for sparse systems, the number of samples needed to guarantee robust and near optimal performance of the designed controller can be significantly smaller than the dimension of the system. Finally, we show that the proposed optimization problem can be solved to global optimality with near-linear time complexity by iteratively solving a series of small quadratic programs.
Adaptive algorithms in the space and time domains (1983)

The basic similarities and essential differences between adaptive processing structures in the space and time domains are considered. Attention is focused on the fact that a cascade structure is required to decorrelate the signals received from different elements of an antenna array, while a very different and more efficient lattice filter structure may be used to decorrelate successive samples of a time series. The difference is explained by examining the Levinson-Durbin recursion algorithm, which essentially gives rise to the lattice filter structure. The algorithm is presented in a generalised form which takes into account the effect of non-stationary statistics and shows clearly how the use of recursion in time is fundamentally responsible for its efficiency. The algorithm is clearly not appropriate for antenna array decorrelation or in the spatial domain generally.
Analysis of the Human Macula by Confocal Laser Tomography (1990)

Laser scanning tomography was used to&#13;\nstudy the surface of the diseased and normal&#13;\nmacula in the human eye. The confocal arrangement&#13;\nof the laser tomographic scanner&#13;\npermits the examination of the retinal topography&#13;\nin the axis perpendicular to the&#13;\nretinal surface. It was found that the normal&#13;\nmacular surface as seen in histological preparations&#13;\ncan be reconstructed in humans&#13;\nwith the laser tomographic scanner. A polarization&#13;\npattern can be observed in the&#13;\narea of Henle's fiber layer. We were able&#13;\nto reproducibly image a brush-like pattern&#13;\nwith the circular polarized laser light in&#13;\nhealthy eyes of 25 patients. In contrast, we&#13;\ndid not observe it in eyes with structural&#13;\nchanges of the macular tissue, indicating&#13;\nthat loss of the brush-like phenomena may&#13;\nbe an early and sensitive indication of macular&#13;\ndiseases. In diseased eyes we were&#13;\nable to assess structural abnormalities, such&#13;\nas macular holes, laser scars, macular&#13;\nbranch vein occlusion and macular edema.&#13;\nThe laser tomographic scanner offers a new&#13;\nmethod to determine the topography of the&#13;\ninternal limiting membrane in the macular&#13;\narea.
Upregulation of mitophagy in enterocytes during intestinal ischemia in rats (2013)

Intestinal ischemia reperfusion (I/R) elicits decreases in mitochondrial respiratory activity and membrane potential, as well as an increase in the mitochondrial‐dependent apoptotic pathway in intestinal enterocytes. However the precise roles of ischemia versus reperfusion in post‐ischemic mitochondrial dysfunction in the gut are unclear. In these studies we have begun to examine the kinetics of mitochondrial dysfunction during the ischemic period. Intestinal enterocytes were isolated from rats after graded periods (up to 40 min) of occlusion of the superior mesenteric artery, and mitochondrial membrane potential (Ψ) and markers of mitophagy and mitochondrial mass were measured. Mitochondrial Ψ (measured by TMRE fluorescence), showed a slight increase by 10 min, but was significantly decreased by 20–40 min ischemia. The autophagosome marker, LC3, showed a time‐dependent increase in the LC3‐II/LC3‐I ratio from 20–40 min ischemia, and there was a shift in the relative distribution of parkin from cytosol to mitochondria by 40 min. Ischemia also elicited cytosolic release of cytochrome c, and decreases in mitochondrial Mfn2 and porin by 40 min. These results indicate that post‐ischemic mitochondrial dysfunction in intestinal enterocytes is preceded by changes in mitochondrial function even prior to reperfusion. Supported by NIH AA‐014945 and HL‐095486.
The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex (2000)

The anaphase-promoting complex (APC) is a cell cycle-regulated ubiquitin-protein ligase that targets cyclin B, securin and other destruction box containing proteins for proteolysis. Nine APC subunits have been identified in vertebrates and eleven in yeast, but for none of them it is known how they contribute to the catalysis of ubiquitination reactions. Here we report the mass spectrometric identification of CDC26 and of the RING-H2 finger protein APC11 in the human APC. We have expressed these proteins and several other APC subunits in Escherichia coli and have tested their activities in vitro. We find that APC11 alone is sufficient to allow the synthesis of multiubiquitin chains in the presence of E1 and UBC4. These multiubiquitin chains are partly unanchored and partly bound to APC11 itself. APC11 and UBC4 are also able to ubiquitinate securin and cyclin B, but these reactions show a decreased dependency on the destruction box. The integrity of the putative zinc binding RING-H2 finger is required for the ability of APC11 to support ubiquitination reactions. These results suggest that APC11 and UBC4 catalyze the formation of isopeptide bonds in APC-mediated ubiquitination reactions.
Mechanisms of Mitochondrial Damage in Keratinocytes by Pemphigus Vulgaris Antibodies (2013)

The development of nonhormonal treatment of pemphigus vulgaris (PV) has been hampered by a lack of clear understanding of the mechanisms leading to keratinocyte (KC) detachment and death in pemphigus. In this study, we sought to identify changes in the vital mitochondrial functions in KCs treated with the sera from PV patients and healthy donors. PV sera significantly increased proton leakage from KCs, suggesting that PV IgGs increase production of reactive oxygen species. Indeed, measurement of intracellular reactive oxygen species production showed a drastic increase of cell staining in response to treatment by PV sera, which was confirmed by FACS analysis. Exposure of KCs to PV sera also caused dramatic changes in the mitochondrial membrane potential detected with the JC-1 dye. These changes can trigger the mitochondria-mediated intrinsic apoptosis. Although sera from different PV patients elicited unique patterns of mitochondrial damage, the mitochondria-protecting drugs nicotinamide (also called niacinamide), minocycline, and cyclosporine A exhibited a uniform protective effect. Their therapeutic activity was validated in the passive transfer model of PV in neonatal BALB/c mice. The highest efficacy of mitochondrial protection of the combination of these drugs found in mitochondrial assay was consistent with the ability of the same drug combination to abolish acantholysis in mouse skin. These findings provide a theoretical background for clinical reports of the efficacy of mitochondria-protecting drugs in PV patients. Pharmacological protection of mitochondria and/or compensation of an altered mitochondrial function may therefore become a novel approach to development of personalized nonhormonal therapies of patients with this potentially lethal autoimmune blistering disease.
Block copolymer modified novolac epoxy resin (2003)

Abstract The phase behavior of uncured and cured mixtures containing stoichiometric amounts of Epon164 novolac epoxy resin and 4,4′‐methylenedianiline combined with a nearly symmetric poly(methyl acrylate‐ co ‐glycidyl methacrylate‐ b ‐polyisoprene) diblock copolymer was investigated with small‐angle X‐ray scattering and transmission electron microscopy. A series of morphologies were documented as a function of the copolymer concentration, which ranged from pure diblock to 2.5 wt % in the thermoset resin. Ordered lamellae bordered a wide multiphase region followed by disordered wormlike micelles that transformed continuously into vesicles at the lowest compositions. The thermal curing of this pentafunctional epoxy system to complete conversion had little impact on the phase behavior of the mixtures, and this was consistent with previous experiments with difunctional epoxy and the same hardening agent. However, changing the epoxy component led to gross changes in the phase behavior that were interpreted with the concept of a wet‐to‐dry brush transition. © 2003 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 41: 1994–2003, 2003
Zur Chemie der Amino‐arsane. I. Zur Kenntnis von Alkylamino‐arsanen mit Adamantanstruktur (1964)

Abstract Bei der Aminolyse von AsCl 3 und der Umaminierung von As(NMe 2 ) 3 mit Methylamin, n‐Butylamin und i‐Propylamin entstehen die Alkylimino‐arsane As 4 (NMe) 6 , As 4 (N‐i‐Pr) 6 und As 4 (N‐n‐Bu) 6 mit Adamantanstruktur. Dagegen ergibt die Aminolyse von AsCl 3 mit tert.‐Butylamin dimeres (t‐BuNHAs‐N‐t‐Bu) 2 . Die selektive Abspaltung der MeN‐Gruppen aus As 4 (NMe) 6 durch HCl führt zu den Verbindungen As 4 (NMe) 5 Cl 2 bzw. (MeNAsCl) 3 . CS 2 reagiert mit As 4 (NR) 6 (R = Me, n‐Bu) unter Bildung von Senfölen und Alkyliminoarsen‐sulfiden.
The Economics of Alternative Tillage Systems, Crop Rotations, and Herbicide use on Three Representative East-Central Corn Belt Farms (1991)

A linear programming model was used to determine which crop rotations and weed management systems result in the highest net farm income for each of three farm sizes (120, 240, and 480 hectares) under alternative tillage systems. Test plot data for the years 1981 through 1988 from the Purdue University Agronomy Farm, which has highly productive, well-drained soils, were analyzed. Net incomes for no-till tillage systems on all farms in the model were consistently and significantly lower than incomes for moldboard and chisel plow tillage systems due to slightly lower yields and substantially higher herbicide costs. Generally, net farm incomes were slightly higher with a moldboard plow versus chisel plow tillage system. Also, as farm size increased, per hectare net incomes increased. About 80% of the time under moldboard or chisel plow tillage systems, the model chose as optimal the lowest of three herbicide application rates. A corn/soybean rotation was chosen as optimal on 56% of the farm area analyzed, versus 25% for continuous corn and 13% for a corn/soybean/wheat rotation.
Gut-derived signaling molecules and vagal afferents in the control of glucose and energy homeostasis (2004)

These recent findings demonstrate that the use of improved anatomical and physiological techniques and animal models with targeted gene modifications lead to an improved understanding of the complex role of gastrointestinal signals in the control of energy homeostasis.
An electron-microscope study of the in vitro transformation of human leucocytes: I transformation of lymphocytes to blastoid cells in the presence of phytohaemagglutinin (1967)

Abstract Electron-microscope studies of cultured small lymphocytes from human peripheral blood transforming into larger blastoid cells in the presence of phytohaemagglutinin (PHA) show that the transformed cell possesses the preliminary stages of development of a protein-synthesizing system. The transformed blastoid cell has abundant ribosomes, although, in contrast with in vivo protein-secreting cells, many of these occur as single particles with only a small proportion linked in polysomal clusters. Endoplasmic reticulum membranes occur to a very limited extent and with a marked paucity of attached ribosomal particles; the few attached particles are usually located in groups. Some endoplasmic reticulum membranes revealed degenerative changes in otherwise normal cells. A moderately well-developed Golgi apparatus was a characteristic feature of the cells. Apart from the relatively low proportion of polysomes, in vitro PHA-transformed blastoid cells are identical in fine structure to in vivo blast cells (otherwise known as immunoblasts, haemocytoblasts, etc.) occurring in the immune response. It is suggested that messenger-RNA production in PHA-stimulated transformed cells may be reduced and that this could explain the limited number of polysomes and the restricted development of the endoplasmic reticulum.
Circadian Variation of Sleep During the Follicular and Luteal Phases of the Menstrual Cycle (2010)

Moderate but significant changes in REM sleep across the menstrual and circadian cycles were observed. These results support an interaction between circadian and menstrual processes in the regulation of REM sleep.
Tensometrie - Entwicklung eines Langzeitmessverfahrens der Tubenfunktion am Felsenbeinpräparat (2010)

To improve the longtime stability of the strain gauge film the next development step will be to make a new design with Konstantan resistors (CU-Ni-Mn). After a testing period, longtime measurements in clinical studies will follow.
The effect of milk feeding method on calves' behavioural sleep (2006)

With appropriate support, wearable activity trackers and mHealth reporting for chronic pain self-care are feasible for use by vulnerable older adults. Future research should test whether the effects of trackers on pain-related outcomes can be enhanced by incorporating behavior change strategies and training in evidence-based cognitive-behavioral techniques.
A Changing Labor Force and Race Relations in Virginia 1660-1710 (1973)

Journal Article A Changing Labor Force and Race Relations in Virginia 1660–1710 Get access T.H. Breen T.H. Breen Search for other works by this author on: Oxford Academic Google Scholar Journal of Social History, Volume 7, Issue 1, Fall 1973, Pages 3–25, https://doi.org/10.1353/jsh/7.1.3 Published: 01 October 1973
Miotic Drugs (1976)

Cholinergic drugs and anticholinesterases have caused ocular complications including cataracts, iris cysts, retinal detachment, iritis, increased intraocular tension, allergic and toxic reactions, and hypermia. The visual complications include accommodative spasm; myopia and reduced visual acuity; changes in vision sensitivity, dark adaptation, and visual fields; and discomfort. The systemic complications are those common to cholinergic drugs and anticholinesterases. This review is intended as a ready reference to the drugs that cause such effects and source material.
Design of high-reliability low-cost amorphous silicon modules for high energy yield (2008)

For PV modules to fulfill their intended purpose, they must generate sufficient economic return over their lifetime to justify their initial cost. Not only must modules be manufactured at a low cost/Wp with a high energy yield (kWh/kWp), they must also be designed to withstand the significant environmental stresses experienced throughout their 25+ year lifetime. Based on field experience, the most common factors affecting the lifetime energy yield of glass-based amorphous silicon (a-Si) modules have been identified; these include: 1) light-induced degradation; 2) moisture ingress and thin film corrosion; 3) transparent conductive oxide (TCO) delamination; and 4) glass breakage. The current approaches to mitigating the effect of these degradation mechanisms are discussed and the accelerated tests designed to simulate some of the field failures are described. In some cases, novel accelerated tests have been created to facilitate the development of improved manufacturing processes, including a unique test to screen for TCO delamination. Modules using the most reliable designs are tested in high voltage arrays at customer and internal test sites, as well as at independent laboratories. Data from tests at the Florida Solar Energy Center has shown that a-Si tandem modules can demonstrate an energy yield exceeding 1200 kWh/kWp/yr in a subtropical climate. In the same study, the test arrays demonstrated low long-term power loss over two years of data collection, after initial stabilization. The absolute power produced by the test arrays varied seasonally by approximately &plusmn;7%, as expected.
Supplemental Table 1 from TumorMap: Exploring the Molecular Similarities of Cancer Samples in an Interactive Portal (2023)

&lt;p&gt;Supplemental Table 1A: Differential expression scores used in the pan-cancer cluster GSEA analysis. These scores represent integrated t-statistic scores from the differential analysis within each tissue (see Supplemental Methods). Supplemental Table 1B: Full results of the GSEA analysis of the pan-cancer cluster, based on differential expression scores. Supplemental Table 1C: Per-sample ESTIMATE scores used in analysis of the pan-cancer cluster. Supplemental Table 1D: Per-sample surrogate purity scores used in analysis of the pan-cancer cluster. Supplemental Table 1E: List of genes located on sex chromosomes that were excluded from the methylation dataset in order to analyze only autosomal gene features. Supplemental Table 1F: Attributes available in the TumorMap that annotate metadata of the samples, along with descriptions of those attributes. Supplemental Table 1G: Statistical tests computed by different attribute enrichment analysis (AEA) tools available in the TumorMap. Supplemental Table 1H: List of 82 samples in the pan-cancer cluster in the integrated map as well as tissue composition, along with the number of samples, in the integrated pan-cancer cluster. Supplemental Table 1I: Input data for the LAML survival analysis.&lt;/p&gt;