gebhart/patrepeval huggingface dataset:
An enantioselective method for reductive alkylation of aromatic carboxylic acid derivatives. Examination of the factors that provide stereoselectivity (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAn enantioselective method for reductive alkylation of aromatic carboxylic acid derivatives. Examination of the factors that provide stereoselectivityArthur G. Schultz, Mark. Macielag, Padmanabhan. Sundararaman, Arthur G. Taveras, and Martha. WelchCite this: J. Am. Chem. Soc. 1988, 110, 23, 7828–7841Publication Date (Print):November 1, 1988Publication History Published online1 May 2002Published inissue 1 November 1988https://pubs.acs.org/doi/10.1021/ja00231a038https://doi.org/10.1021/ja00231a038research-articleACS PublicationsRequest reuse permissionsArticle Views1826Altmetric-Citations65LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Preparation of Cross‐Linked Poly[(ε‐caprolactone)‐co‐lactide] and Biocompatibility Studies for Tissue Engineering Materials (2007)

In this study, cross-linked materials were prepared using the branched macromonomer with different CL/LA molar ratios, and feasibility studies for tissue engineering were carried out. The thermal and mechanical properties of these materials depended on the CL/LA compositions; however, there was no change in the wettability of each material. The HeLa cells adhesion and growth on the CL-LA7030c were equal to that on the commercially available polystyrene dish. The protein absorption experiment using the FBS proteins revealed that the materials with well-grown cells showed better adhesion of the proteins. [photo: see text]
A theory of transfer bond resistance of deformed reinforcing bars in concrete under lateral pressure (1987)

Synopsis The basic bond mechanism for reinforcing bars in concrete under external pressure is considered and an existing partly cracked elastic theory for bond resistance is extended to cover both uniform and non-uniform distributions of external pressure. Results obtained from this theory are compared with experimental results at various stages of bond failure. The prediction of pull-out force at 0·1 mm free-end slip is found to be satisfactory.
Some factors influencing yield and cation sum and ratios in corn (1975)

Abstract Maximum yields of corn depends on adequate and balanced supplies of essential nutrients. In order to elucidate some of the factors which influence yields, a study was initiated to evaluate K, Ca, and Mg balances as influenced by seasonal variation, age of plants, and rates of K application. Corn was grown three consecutive years on a Hartsells loam at three levels of applied K. Significant yield response to applied K was observed. The level of response to K was dependent upon weather conditions. Fertilizer K, age, and yearly variation resulted in significant changes in the sum of the cations (K+Ca+Mg), and the K/Ca, K/Mg, and K/(Ca+Mg) ratios in corn leaf tissue. Grain yield and K concentration in corn tissue increased while the tissue concentration of Ca and Mg decreased as a result of K application.
Exposure reconstruction for reducing uncertainty in risk assessment: example using MTBE biomarkers and a simple pharmacokinetic model (2007)

Adverse health risks from environmental agents are generally related to average (long-term) exposures. Because a given individual's contact with a pollutant is highly variable and dependent on activity patterns, local sources and exposure pathways, simple 'snapshot' measurements of surrounding environmental media may not accurately assign the exposure level. Furthermore, susceptibility to adverse effects from contaminants is considered highly variable in the population so that even similar environmental exposure levels may result in differential health outcomes in different individuals. The use of biomarker measurements coupled to knowledge of rates of uptake, metabolism and elimination has been suggested as a remedy for reducing this type of uncertainty. To demonstrate the utility of such an approach, we invoke results from a series of controlled human exposure tests and classical first-order rate kinetic calculations to estimate how well spot measurements of methyl tertiary butyl ether and the primary metabolite, tertiary butyl alcohol, can be expected to predict different hypothetical scenarios of previous exposures. We found that blood and breath biomarker measurements give similar results and that the biological damping effect of the metabolite production gives more stable estimates of previous exposure. We also explore the value of a potential urinary biomarker, 2-hydroxyisobutyrate suggested in the literature. We find that individual biomarker measurements are a valuable tool in reconstruction of previous exposures and that a simple pharmacokinetic model can identify the time frames over which an exogenous chemical and the related chemical biomarker are useful. These techniques could be applied to broader ranges of environmental contaminants to assess cumulative exposure risks if ADME (Absorption, Distribution, Metabolization and Excretion) is understood and systemic biomarkers can be measured.
[Axillary plexus anesthesia in noncooperative patients]. (1983)

In 36 non-cooperative patients we performed block of the axillary brachial plexus by using a well recognized catheter technique. A flexible, disposable intravenous cannula was placed into the axillary neurovascular sheath and used for injection of local anaesthetic solution without adverse sequelae. Analgesia for acute and elective surgical procedures was obtained rapidly and independent of any patient's assistance in all cases. Catheter axillary block seems to be a valuable anaesthetic technique in the difficult and risky management of non-cooperative patients.
Steric effects in fast thermal Z,E isomerization of overcrowded ethylenes. Conformational behavior of N,N'-dimethylbiacridans (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSteric effects in fast thermal Z,E isomerization of overcrowded ethylenes. Conformational behavior of N,N'-dimethylbiacridansIsrael Agranat and Yitzhak TapuhiCite this: J. Am. Chem. Soc. 1978, 100, 18, 5604–5609Publication Date (Print):August 1, 1978Publication History Published online1 May 2002Published inissue 1 August 1978https://pubs.acs.org/doi/10.1021/ja00486a004https://doi.org/10.1021/ja00486a004research-articleACS PublicationsRequest reuse permissionsArticle Views181Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Ultrafast Tunable Optical Delay Line Based on Indirect Photonic Transitions (2012)

We introduce the concept of an indirect photonic transition and demonstrate its use in a dynamic delay line to alter the group velocity of an optical pulse. Operating on an ultrafast time scale, we show continuously tunable delays of up to 20 ps, using a slow light photonic crystal waveguide only 300 μm in length. Our approach is flexible, in that individual pulses in a pulse stream can be controlled independently, which we demonstrate by operating on pulses separated by just 30 ps. The two-step indirect transition is demonstrated here with a 30% conversion efficiency.
Y-a-t-il une rétraction au cours de la cicatrisation par seconde intention des plaies au laser CO2 ? (1993)

info:eu-repo/semantics/published
A compact mesoband microwave radiation system (2022)

A compact mesoband radiation system is designed and tested. The system is composed of a charging power supply, a Marx generator, a switched quarter-wavelength oscillator, and a circularly polarized patch antenna. The Marx generator outputs a fast high-voltage pulse with a rise time of 10 ns and an amplitude of 100 kV, which is used to charge the oscillator. The oscillator consists of a quarter-wavelength coaxial transmission line, a ring ground switch, and a coupler. It generates a mesoband oscillation pulse with a center frequency of 350 MHz and a percentage bandwidth of 10%. The oscillation pulse is radiated by the circularly polarized patch antenna. The measured radiation factor is greater than 50 kV, and the radiation waveform is consistent with the simulation waveform.
Compact deep UV laser system at 222.5 nm by single-pass frequency doubling of high-power GaN diode laser emission (2016)

Deep ultraviolet (DUV) lasers emitting below 300 nm are of great interest for many applications, for instance in medical diagnostics or for detecting biological agents. Established DUV lasers, e.g. gas lasers or frequency quadrupled solid-state lasers, are relatively bulky and have high power consumptions. A compact and reliable laser diode based system emitting in the DUV could help to address applications in environments where a portable and robust light source with low power consumption is needed. In this work, a compact DUV laser system based on single-pass frequency doubling of highpower GaN diode laser emission is presented. A commercially available high-power GaN laser diode from OSRAM Opto Semiconductors serves as a pump source. The laser diode is spectrally stabilized in an external cavity diode laser (ECDL) setup in Littrow configuration. The ECDL system reaches a maximum optical output power of 700 mW, maintaining narrowband emission below 60 pm (FWHM) at 445 nm over the entire operating range. By direct single pass frequency doubling in a BBO crystal with a length of 7.5 mm a maximum DUV output power of 16 &mu;W at a wavelength of 222.5 nm is generated. The presented concept enables compact and efficient diode laser based light sources emitting in the DUV spectral range that are potentially suitable for in situ applications where a small footprint and low power consumption is essential.
Analysis of Droplet Spreading on a Rotating Surface and the Prediction of Cooling and Lubrication Performance of an Atomization-Based Cutting Fluid System (2013)

Droplet spreading on a rotating surface has been modeled with an aim to design an efficient atomization-based cutting fluid (ACF) system for micromachining processes. To this end, single-droplet impingement experiments are conducted on a rotating surface to capture the 3D shape of a droplet upon impingement. A parameterization scheme is then developed to mathematically define the 3D shape of droplet upon impingement. The shape information is used to develop an energy-based model for droplet spreading. The droplet spreading model captures the experimental results within 10% accuracy. The spreading model is then used to predict the cooling and lubrication for an ACF-based microturning process. The model captures the cooling and lubrication trends observed in microturning experiments. A parametric study is conducted to identify the significant factors affecting the performance of an ACF system. Droplet speed is found to have a dominant effect on both cooling and lubrication performance, particularly, with a low surface tension fluid for cooling and a low surface tension and high viscosity fluid for lubrication.
Payment and provider profiling of episodes of illness of clinical illnesses involving rehabilitation. (2001)

The prevailing trend in American health care finance for the last two decades and likely for the forseeable future, is the movement from a system based on fee for service payments to one dominated by capitation arragements. At the core of this change is a shifting of risk from payers to providers. Such a fundamental transition is not without its difficulties. This is exemplified by some of the problems experienced by the Health Care Financing Administration (HCFA) as it has begun to encourage beneficiaries to move from traditional fee for service Medicare to capitated HMOs. The most recently published regulations involving risk adjustment of rates of payment for managed care organizations (MCOs) did not find much favor as the statistical power was poor and the clinical meaningfulness of the risk adjustment was highly problematic. Specifically, the risk adjustment explained less than 10% of the variation in costs (compared to approximately 30% when DRGs were first implemented). From a clinical perspective, the methodology only used hospitalization data for adjustment of capitation rates; that is, anyone who was not hospitalized was assumed to be healthy! It is known that payment for rehabilitation services is among the most difficult to understand and predict of all medical care. This article will summarize the development of a new risk adjustment methodology which should be particularly useful for payment and monitoring of episodes of clinical conditions that involve rehabilitation. The article will conclude with directions for future research.
Studies on the presentation of Pseudomonas exotoxin to the host immune system : implications for vaccine development / (1999)

Pseudomonas exotoxin (PE) belongs to a family of bacterial ADP-ribosylating toxins that have been extensively studied as virulence factors which contribute to the pathogenesis of the bacterium and as immunogens for the development of vaccines.The present study focuses on the intracellular processing of PE and non-cytotoxic derivatives with regard to potential applications for vaccine development.The ability of PE fusion proteins to deliver exogenously added antigen for presentation by both MHC class 1 and class H molecules was examined.A fusion protein linking a non-cytotoxic derivative of PE proinsulin led to presentation o f an epitope that is presented by the murine class II MHC molecule lA*^.Experiments with biochemical inhibitors suggest this epitope was processed and presented in manner typical for a class II antigen.However, an MHC class I-restricted epitope from the melanoma antigen gp 100 fused to PE was processed by a mechanism that differs from the conventional class I processing pathway.Immunomodulatory properties of native PE and non-cytotoxic derivatives of PE were investigated.Native PE is immunostimulatory, and acts as a weak T cell mitogen.All PE antigens examined stimulated IL-ip production, but only non-cytotoxic forms stimulated EL-6 , TNF-a, and GM-CSF production.However, native PE was a potent ii stimulator o f IFN-y and suppressed EL-8 production.The characterization of PE as an immunomodulatory molecule supports the development and use of PE-derivatives for clinical applications.The promising arena of DNA-based vaccines has led us to investigate possible candidates for immunization against bacterial pathogens.To study the biologic effect of PE following in situ expression, eukaryotic plasmid expression vectors containing either the wildtype or a mutated, non-cytotoxic toxA gene were constructed.Evidence suggests that expression o f the wildtype toxA gene is lethal for transfected cells.Immunizationwith the mutated toxA gene results in production of neutralizing antibodies against native PE and potentiates a Tyl-type response, whereas only a minimal humoral response can be detected in mice immunized with wildtype toxA.Taken together, PE interacts in a complex fashion with the immune system, partly due to its intricate intracellular processsing events, and has potential application in many aspects of vaccine development.Ill Dedicated to everyone who inspired me to follow my dreams IV
Acyl radicals: functionalized free radicals for intramolecular cyclization reactions (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAcyl radicals: functionalized free radicals for intramolecular cyclization reactionsDale L. Boger and Robert J. MathvinkCite this: J. Org. Chem. 1988, 53, 14, 3377–3379Publication Date (Print):July 1, 1988Publication History Published online1 May 2002Published inissue 1 July 1988https://doi.org/10.1021/jo00249a053RIGHTS & PERMISSIONSArticle Views870Altmetric-Citations63LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (325 KB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Is Enhanced Fetal Growth a Risk Factor for the Development of Atopy or Asthma? (1999)

These findings raise the hypothesis that factors responsible for fetal growth may also lead to programming of the developing respiratory or immune systems, predisposing to the subsequent development of asthma and/or atopy. This hypothesis may explain, in part, the increasing prevalence of asthma and atopy over recent decades, which has occurred concurrently with secular trends for improved fetomaternal health, as measured by anthropometric measurements at birth.
ABCMETAapp: R shiny application for simulation‐based estimation of mean and standard deviation for meta‐analysis via approximate Bayesian computation (2021)

In meta-analysis based on continuous outcome, estimated means and corresponding standard deviations from the selected studies are key inputs to obtain a pooled estimate of the mean and its confidence interval. We often encounter the situation that these quantities are not directly reported in the literatures. Instead, other summary statistics are reported such as median, minimum, maximum, quartiles, and study sample size. Based on available summary statistics, we need to estimate estimates of mean and standard deviation for meta-analysis. We developed an R Shiny code based on approximate Bayesian computation (ABC), ABCMETA, to deal with this situation. In this article, we present an interactive and user-friendly R Shiny application for implementing the proposed method (named ABCMETAapp). In ABCMETAapp, users can choose an underlying outcome distribution other than the normal distribution when the distribution of the outcome variable is skewed or heavy tailed. We show how to run ABCMETAapp with examples. ABCMETAapp provides an R Shiny implementation. This method is more flexible than the existing analytical methods since estimation can be based on five different distributions (Normal, Lognormal, Exponential, Weibull, and Beta) for the outcome variable.
Gut microbiota in Malawian infants in a nutritional supplementation trial (2015)

Nutritional supplementation by LNS or corn-soya blend for twelve months did not affect the gut microbiota profile in the rural Malawian context.
The inventive scribe (2013)

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Statistical techniques in modeling of complex systems: Single and multiresponse models (1983)

An exposition of statistical techniques in modeling complex systems (single and multiresponse models) that are representative of recent work on modeling systems is provided. The paper begins with several basic concepts related to linear and nonlinear models. The authors then examine four representative techniques of model discrimination which deal with use of nonintrinsic and intrinsic parameters, use of Bayesian methods, and likelihood discrimination. Next they examine multiresponse models with issues dealing with design of experiments for parameter estimation and model discrimination. A case study on sequential model discrimination in multiresponse models is also discussed. Finally an overview on estimating parameters in models of a dynamical system is briefly discussed. The paper concludes with a summary of unresolved issues, and with suggestions on the future role of modeling in the complex situation.
(Invited) Moving Electrons and Holes through Porous MOFs and MOF-Supported Catalysts (2018)

Porous, thin-film, water stable metal-organic frameworks (MOFs) are potentially highly attractive as electrocatalysts as they can present reactant-accessible catalysts at high areal concentration on electrode surfaces. Indeed, such films, if constructed from molecular catalysts, can present the equivalent of several hundred monolayers or more of catalyst -- amounts that can translate into decreases of hundreds of millivolts in kinetic overpotential relative to overpotentials for otherwise equivalent solution-phase electrocatalysts present at millimolar concentrations. Similar conclusions can be reached for catalysts consisting of MOF-node-supported, metal-oxygen or metal-chalcogen clusters. Required for efficacious electrocatalysis, however, is reasonable electrical conductivity, where the basis for conductivity may be site-to-site redox hopping or may instead operationally resemble band-like electronic conductivity. For electrode-supported MOF films having thicknesses of around a micron, site-to-site charge hopping rates on the order of 10 5 sec -1 should be sufficient to sustain catalytic currents of tens of mA/cm 2 . Alternatively, MOF electronic conductivities on the order of 10 -2 Siemens/cm (roughly seven and a half orders of magnitude less than the conductivity of copper) should be sufficient to sustain catalytic currents of tens of mA/cm 2 with only marginal iR penalties. Thus, in comparison to many applications, the degree of conductivity required for MOF thin-film mediated electrocatalysis is modest. This presentation will describe some approaches to rendering highly-porous MOF films sufficiently electrically conductive to support electrocatalysis. Included will be examples of highly anisotropic electrical conductivity, underscoring the role that MOF topology can play in defining both hopping-like and band-like conductivity. Also included may be examples of intentional chemical modulation of MOF conductivity. Based on these and other examples, some potentially transferrable principles for designing electrocatalysis-competent, conductive MOFs will be proffered.