gebhart/patrepeval huggingface dataset:
Flash kinetic spectroscopic studies of dinuclear rhodium(I) complexes (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFlash kinetic spectroscopic studies of dinuclear rhodium(I) complexesVincent M. Miskowski, Glenn L. Nobinger, David S. Kliger, George S. Hammond, Nathan S. Lewis, Kent R. Mann, and Harry B. GrayCite this: J. Am. Chem. Soc. 1978, 100, 2, 485–488Publication Date (Print):January 1, 1978Publication History Published online1 May 2002Published inissue 1 January 1978https://pubs.acs.org/doi/10.1021/ja00470a020https://doi.org/10.1021/ja00470a020research-articleACS PublicationsRequest reuse permissionsArticle Views228Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Single-layer guided-mode resonance polarizer (2007)

Optical characteristics of an e-beam patterned guided-mode resonance polarizer are presented. Parameters of the fabricated device are confirmed by AFM. Experimental spectral response of the polarizer agrees qualitatively with theory.
Experimental Verification of an Aerial Image Evaluation Method and Its Application to Studies of Attenuated Phase-Shifting Masks (1995)

Attenuated phase-shifting masks can improve the resolution of optical lithography, and an accurate aerial image evaluaton method is necessary for optimizing parameters. In a positive-tone chemically amplified resist, WKR-PT2, the actual resist pattern size can be easily estimated from the aerial image. This was experimentally verified by evaluating both binary and attenuated phase-shifting masks, and it was established that the secondary peak resolution limits can also be estimated from an aerial image. Further study indicated that this resolution limit in dense patterns is determined by numerical aperture, wavelength, and target hole size. Optimization of numerical aperture and pattern layout is necessary before attenuated phase-shifting masks can be put to practical use.
Cusp Points in the Parameter Space of Degenerate 3-RPR Planar Parallel Manipulators (2012)

This paper investigates the conditions in the design parameter space for the existence and distribution of the cusp locus for planar parallel manipulators. Cusp points make possible nonsingular assembly-mode changing motion, which increases the maximum singularity-free workspace. An accurate algorithm for the determination is proposed amending some imprecisions done by previous existing algorithms. This is combined with methods of cylindric algebraic decomposition, Gröbner bases, and discriminant varieties in order to partition the parameter space into cells with constant number of cusp points. These algorithms will allow us to classify a family of degenerate 3-RPR manipulators.
A conserved SH3-like fold in diverse putative proteins tetramerizes into an oxidoreductase providing an antimicrobial resistance phenotype (2023)

We present a potential mechanism for emergence of catalytic activity that is essential for survival, from a non-catalytic protein fold. The type B dihydrofolate reductase (DfrB) family of enzymes were first identified in pathogenic bacteria because their dihydrofolate reductase activity is sufficient to provide trimethoprim (TMP) resistance. DfrB enzymes are described as poorly evolved as a result of their unusual structural and kinetic features. No characterized protein shares sequence homology with DfrB enzymes; how they evolved to emerge in the modern resistome is unknown. In this work, we identify DfrB homologues from a database of putative and uncharacterized proteins. These proteins include an SH3-like fold homologous to the DfrB enzymes, embedded in a variety of additional structural domains. By means of functional, structural and biophysical characterization, we demonstrate that these distant homologues and their extracted SH3-like fold can display dihydrofolate reductase activity and confer TMP resistance. We provide evidence of tetrameric assembly and catalytic mechanism analogous to that of DfrB enzymes. These results contribute, to our knowledge, the first insights into a potential evolutionary path taken by this SH3-like fold to emerge in the modern resistome following introduction of TMP. This article is part of the theme issue 'Reactivity and mechanism in chemical and synthetic biology'.
Blood flow restriction does not alter the early hypertrophic signaling and short-term adaptive response to resistance exercise when performed to task failure (2023)

Previous research supports that low-load resistance exercise with blood flow restriction (LL-BFR) acutely increases physiological responses and muscle mass accrual compared with low-load resistance exercise (LL-RE) alone. However, most studies have work-matched LL-BFR and LL-RE. Completing sets to similar perceived efforts, thereby allowing for a variable amount of work, may provide a more ecologically valid approach to compare LL-BFR and LL-RE. This study aimed to examine acute signaling and training responses following LL-RE or LL-BFR performed to task failure. Ten participants had each leg randomly assigned to perform LL-RE or LL-BFR. Muscle biopsies were obtained before and 2-h after the first exercise bout and after 6-wk of training for Western blot and immunohistochemistry analyses. Repeated measure ANOVA and intraclass coefficients (ICCs) were used to compare responses of each condition. After exercise, AKT<sup>(T308)</sup> phosphorylation increased after LL-RE and LL-BFR (both ∼145% of baseline, <i>P</i> < 0.05) and trended for p70 S6K<sup>(T389)</sup> (LL-RE: ∼158% and LL-BFR: ∼137%, <i>P</i> = 0.06). BFR did not alter these responses, resulting in fair-excellent ICCs for signaling proteins involved in anabolism (ICC<sub>AKT(T308)</sub> = 0.889, <i>P</i> = 0.001; ICC<sub>AKT(S473)</sub> = 0.519, <i>P</i> = 0.074; ICC<sub>p70 S6K(T389)</sub> = 0.514, <i>P</i> = 0.105). After training, muscle fiber cross-sectional area and vastus lateralis whole muscle thickness were similar between conditions (ICC ≥ 0.637, <i>P</i> ≤ 0.031). Similar acute and chronic responses between conditions and high ICC values between legs suggest that both LL-BFR and LL-RE performed by the same person result in similar adaptations. These data support the concept that sufficient muscular exertion is a key factor for training-induced muscle hypertrophy with low-load resistance exercise independent of total work and blood flow.<b>NEW & NOTEWORTHY</b> The addition of blood flow restriction during low-load resistance exercise is considered to increase the signaling events and muscle growth responses to a greater extent than low-load resistance exercise alone. It remains unclear whether blood flow restriction accelerates or increases these adaptive responses, as most studies have each condition perform the same amount of work. Despite different amounts of work performed, we show similar signaling and muscle growth responses occur after low-load resistance exercise with and without blood flow restriction. Our work supports that blood flow restriction accelerates fatigue but does not increase the signaling events and muscle growth responses during low-load resistance exercise.
A New Model for Aluminophosphate Formation: Transformation of a Linear Chain Aluminophosphate to Chain, Layer, and Framework Structures (1998)

Simple transformations of an unbranched parent chain lead to a diverse range of aluminophosphates with 1D chain, 2D porous layer, and 3D open-framework structures. A section of this chain, which has been hydrolyzed in one position leading to ring-opening, is shown schematically below. Reorientation of the chain followed by renewed condensation leads to, for example, two edge-sharing four-rings. In this case water acts as a catalyst; thus the amount of water present during the synthesis determines the degree of hydrolysis and therefore the resulting structure type.
ChemInform Abstract: ASYMMETRISCHE SYNTHESEN UEBER HETEROCYCLISCHE ZWISCHENSTUFEN. 6. MITT. ENANTIOSELEKTIVE SYNTHESE VON (R)‐AMINOSAEUREN UNTER VERWENDUNG VON L‐VALIN ALS CHIRALEM HILFSSTOFF (1981)

Abstract Das ausgehend von L‐Valin (I) und dem Glycinester (II) erhältliche Cyclopeptid (III) wird in den Bislactimether (IV) übergeführt, der bei der Alkylierung mit den Halogeniden (V) stereoselektiv die Produkte (VI) liefert.
En Face Spectral-Domain Optical Coherence Tomography for the Monitoring of Lesion Area Progression in Stargardt Disease (2016)

The current study describes, for the first time in literature, a longitudinal analysis of the macular lesion area assessed by SD-OCT in STGD1 disease, showing a significant progression over the follow-up. Our findings suggest that the evaluation of macular lesion area by en face SD-OCT, together with FAF, could drive the choice of the most amenable candidates and the most suitable area to be treated in gene therapy clinical trials.
Efficient polysilicon passivation layer for crosstalk reduction in high-resistivity SOI substrates (2010)

Substrate crosstalk and RF losses in HR-SOI, and the introduction of a stabilized polysilicon layer are deeply investigated. A new equivalent lumped circuit to model different substrate types and resistivities, and SiO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> -Si interface qualities is proposed and validated by simulation and experimental data. It is also valid to model the introduction of high-trap density at the interface, and it successfully explains the higher measured values of substrate crosstalk at low frequencies for HR-Si substrates.
Dynamic aberration correction for multiharmonic microscopy (2009)

We demonstrate image-based aberration correction in a third-harmonic generation (THG) microscope. We describe a robust, mostly sample-independent correction scheme relying on prior measurement of the influence of aberration modes produced by a deformable mirror on the quality of THG images. We find that using image sharpness as an image quality metric, correction of N aberration modes is achieved using 2(2N+1) measurements in a variety of samples. We also report aberration correction in combined multiharmonic and two-photon excited fluorescence experiments. Finally, we demonstrate time-dependent adaptive THG imaging in developing embryonic tissue.
Противогерпетическая активность производных нетропсина в опытах на лабораторных животных (2012)

Two dimeric netropsin derivatives (Lys-bis-Nt и 15Lys-bis-Nt) were comprehensively tested for antiviral and toxic activity in cell cultures and laboratory animals. The two compounds were found to provide effective and selective inhibition of reproduction of herpes simplex I both in cell culture Vero E6 and in brain of infected white mice, thereby increasing the survival rate and mean life expectation of treated animals as compared to control.
Postmenopausal Estrogens—Opposed, Unopposed, or None of the Above (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Homochiral Metal Organic Frameworks and Their Usage for the Enantio‐Purification of Racemic Drugs (2018)

Abstract Three new homochiral MOFs (MOF‐808‐S‐ibuprofen, MOF‐808‐S‐proline and MOF‐808‐S‐lactic acid) were synthesized via the post synthetic modification of achiral MOF‐808 and were characterized by various analytical tools. The new homochiral MOFs (HCMOFs) were examined for the enantioselective adsorption of racemic drugs. The n‐hexane solution of racemic ibuprofen, ketoprofen and flurbiprofen were allowed to adsorb in the chiral channels of the HCMOFs. The drugs were desorbed form porous HCMOFs and analysed by chiral HPLC. MOF‐808‐S‐ibuprofen selectively adsorbed R ‐ibuprofen and R ‐ketoprofen with enantiomeric excess ( ee ) of 50 and 56% respectively.
Induction of spermatogenesis with gonadotrophins in Chinese men with hypogonadotrophic hypogonadism (1994)

The effects of gonadotrophin administration to 17 Chinese patients with hypogonadotrophic hypogonadism (HH) on testicular volume and induction of spermatogenesis were studied. Ten subjects had isolated HH and seven had hypopituitarism. Twelve of the subjects had prepubertal onset of HH and five of them had been treated previously with hCG for induction of puberty. None had a history of cryptorchidism. During hCG treatment for induction of spermatogenesis, all subjects had an increase in serum levels of testosterone into the normal adult male range and their testes increased in size from 3 (1-20) ml to 11.6 (5-20) ml [median(range), p < 0.02]. Six subjects required treatment with hCG alone. However, the remaining 11 subjects, after at least 6 months treatment with hCG, required the addition of human menopausal gonadotrophin (hMG) to induce spermatogenesis. Two subjects remained azoospermic. One had a history of mumps orchitis and the other had isolated elevation of blood FSH levels, suggestive of primary testicular failure in addition to HH. Excluding one subject with fertile eunuch syndrome, the mean duration for first appearance of spermatozoa was 13 (4-52) months. Twelve subjects became fertile and pregnancy was achieved in their partners after 20 (4-78) months. The weekly doses for hCG and hMG were 4000 (3000-10,000) IU and 225 (225-450) IU, respectively. Patients who responded to hCG alone had a significantly larger pretreatment testicular volume, suggesting that they had only partial gonadotrophin deficiency. Prepubertal onset of hypogonadism was not a determining factor for requirement of hMG treatment.(ABSTRACT TRUNCATED AT 250 WORDS)
Special situations: Intradialytic hypertension/chronic hypertension and intradialytic hypotension (2017)

Hypertension is a comorbidity that is present in the majority of end-stage renal disease patients on maintenance hemodialysis. This population is particularly unique because of the dynamic nature of blood pressure (BP) during dialysis. Modest BP decreases are expected in most hemodialysis patients, but intradialytic hypotension and intradialytic hypertension are two special situations that deviate from this as either an exaggerated or paradoxical response to the dialysis procedure. Both of these phenomena are particularly important because they are associated with increased mortality risk compared to patients with modest decreases in BP during dialysis. While the detailed pathophysiology is complex, intradialytic hypotension occurs more often in patients prescribed fast ultrafiltration rates, and reducing this rate is recommended in patients that regularly exhibit this pattern. Patients with intradialytic hypertension have a poorly explained increase in vascular resistance during dialysis, but the consistent associations with extracellular volume overload point toward more aggressive fluid management as the initial management choices for these patients. This up to date review provides the most recent evidence supporting these recommendations as well as the most up to date epidemiologic and mechanistic research studies that have added to this area of dialysis management.
B Cell Cytokine Expression Patterns in Nasal Polyps (2010)

Free accessAbstractFirst published online August 2010B Cell Cytokine Expression Patterns in Nasal PolypsAnnalisa Overstreet, MD, presenter, James Hadley, MD, and Ignacio Sanz, MDView all authors and affiliationsVolume 143, Issue 2_supplhttps://doi.org/10.1016/j.otohns.2010.06.699
Subclass Pattern Recognition: A Maximin Correlation Approach (1995)

This paper addresses a correlation based nearest neighbor pattern recognition problem where each class is given as a collection of subclass templates. The recognition is performed in two stages. In the first stage the class is determined. Templates for this stage are created using the subclass templates. Assignment into subclasses occurs in the second stage. This two stage approach may be used to accelerate template matching. In particular, the second stage may be omitted when only the class needs to be determined.We present a method for optimal aggregation of subclass templates into class templates. For each class, the new template is optimal in that it maximizes the worst case (i.e., minimum) correlation with its subclass templates. An algorithm which solves this maximin optimization problem is presented and its correctness is proved. In addition, test results are provided, indicating that the algorithm's execution time is polynomial in the number of subclass templates.We show tight bounds on the maximin correlation. The bounds are functions only of the number of original subclass templates and the minimum element in their correlation matrix.The algorithm is demonstrated on a multifront optical character recognition problem.
Analysis of the Protein Constituency of Developing Cotton Fibres (1988)

Graves, D. A. and Stewart, J. McD. 1988. Analysis of the protein constituency of developing cotton fibres.—J. exp. Bot. 39: 59–69. Protein composition of young cotton (Gossypium hirsuium L.) ovules and fibres was examined in order to characterize gross changes during early development and to determine if changes correspond to known developmental events. Major emphasis was on the fibre, although ovule development was considered at earlier ages. Ovules and fibres from upland cotton (‘Deltapine 61’) were collected at 6, 3, and 1 d pre-anthesis, at anthesis and at 2, 6, 10, 16 and 20 d post-anthesis. Total protein was extracted from whole ovules or isolated fibres and subjected to two-dimensional gel electrophoresis. The gels indicated the following: (1) The protein patterns of ovules and fibres 3 d pre-anthesis to 2 d post-anthesis were relatively similar, suggesting a plateau in protein expression. The plateau was proposed to reflect the time during which fibre cells are differentiated from other epidermal cells. (2) The plateau was delineated by apparent periods of increased complexity in the population at 3 d pre-anthesis and 2 d post-anthesis. (3) A transition in the protein population occurred between 2 and 10 d post-anthesis. (4) By 6 to 10 d post-anthesis, the fibre began to express proteins putatively involved with secondary wall synthesis. (5) Increases in spot intensity of certain proteins around 16 d post-anthesis may correlate with cellulose synthesis reported by others to peak about this time. These observations suggest that early ovule and fibre development is characterized by at least two distinct protein populations. The first occurs around anthesis and the second occurs by 10 d and extends to 20 d post-anthesis and beyond.
Structure−Activity Relationship of Newly Synthesized Quinoline Derivatives for Reversal of Multidrug Resistance in Cancer (1997)

The effect of 24 newly synthesized quinoline derivatives on tumor cell multidrug resistance (MDR) was examined in vitro. At low concentrations, these compounds enhanced the accumulation of [3H]vincristine in K562/ADM cells and reversed tumor cell MDR. The results of the structure-activity relationship analysis indicate that in highly active compounds the two aryl rings in the hydrophobic moiety deviate from a common plane, so they are capable of interacting with hydrogen bond donors of P-170 glycoprotein (P-gp) via pi-hydrogen-pi interactions. Other major structural features which influence the MDR-reversing activities of these compounds are a quinoline nitrogen atom and a basic nitrogen atom in piperazine. Furthermore, in highly active compounds, the distance between the hydrophobic moiety and the basic nitrogen atom (an atom connected to 2-hydroxypropoxyquinoline) must be at least 5 A. Several compounds were found to reverse vincristine resistance in K562/ADM cells in vitro, and compound 16 (MS-209) was selected for clinical studies.
MEMS Colloid Thruster Array (2005)

Abstract : TDA designed a single MEMS colloid emitter that can be readily extended to a multi-emitter array. The annular electrodes proposed by TDA and UC-Boulder have high local electric field strength at the nozzle to reduce the voltage needed to activate the electrospray. They also designed a fluidic valve to passively meter flow to each emitter in the array. Detailed micro fabrication process recipes were developed and proven by actually building single emitters. A laboratory test rig has been built, validation tests were conducted using a conventional colloid capillary emitter and tests were attempted using a single MEMS colloid emitter. 0 Annular emitter electrodes - The annular emitter electrode design doubles the electric field strength in comparison to a full base electrode and thus, lowers the voltage needed to activate the electrospray. It can be micro machined using lithography and vapor deposition processes. 0 High voltage dielectrics - Teflon films will be used during colloid emitter development to reduce risk. In parallel task, we will develop and evaluate high quality sputtered silicon dioxide layers based on recent work at the University of Colorado MRTL. Using their equipment and sputter process we can create layers up to 10 pm thick; more than enough for high voltage actuation to 5 kV.