gebhart/patrepeval huggingface dataset:
The effects of head-mounted display attributes on human visual perception of region warping distortions (2005)

The human visual system has a limited perception of detail. In immersive virtual reality systems, perceptually based computer graphics techniques are often used to optimize system performance. Priority rendering is a rendering technique used in conjunction with an Address Recalculation Pipeline virtual reality system, in order to reduce the overall rendering load. Further reductions to the overall rendering load have been achieved through the segmenting of large objects for priority rendering. Region warping was devised to hide scene tearing artefacts that potentially emerge as a result of implementing large object segmentation with priority rendering. Region warping however, introduces slight distortions to the graphics. It is important to understand to what extent these distortions are perceptible to a user. This paper investigates how different head mounted display attributes like field of view and resolution might affect a user's visual perception of region warping distortions.
ANTIFERROMAGNETIC ORDERING IN Y-BA-CU-PT-O (1987)

A high temperature superconducting Y-Ba-Cu-Pt-O compound has been investigated. The results on magnetization and magnetic susceptibility of the compound are presented. A hysteresis of the magnetic moment at 4.2K is observed. This hysteresis occures, most probably, due to an antiferromagnetic ordering in the material. The Curie asymtotic temperature and Nèel temperature of the material are reported.
Molecular architecture of inner dynein arms in situ in Chlamydomonas reinhardtii flagella (2008)

The inner dynein arm regulates axonemal bending motion in eukaryotes. We used cryo-electron tomography to reconstruct the three-dimensional structure of inner dynein arms from Chlamydomonas reinhardtii. All the eight different heavy chains were identified in one 96-nm periodic repeat, as expected from previous biochemical studies. Based on mutants, we identified the positions of the AAA rings and the N-terminal tails of all the eight heavy chains. The dynein f dimer is located close to the surface of the A-microtubule, whereas the other six heavy chain rings are roughly colinear at a larger distance to form three dyads. Each dyad consists of two heavy chains and has a corresponding radial spoke or a similar feature. In each of the six heavy chains (dynein a, b, c, d, e, and g), the N-terminal tail extends from the distal side of the ring. To interact with the B-microtubule through stalks, the inner-arm dyneins must have either different handedness or, more probably, the opposite orientation of the AAA rings compared with the outer-arm dyneins.
Phase I dose escalation study of nivolumab (Anti-PD-1; BMS-936558; ONO-4538) in patients (pts) with advanced hepatocellular carcinoma (HCC) with or without chronic viral hepatitis. (2013)

TPS3111 Background: Pts with advanced HCC have limited treatment options. Sorafenib, the current standard of care, achieves only modest overall survival improvements. There is a clear etiologic association between HCC and prior/concurrent hepatitis B (HBV) or C (HCV) infection. Programmed death-1 (PD-1) is an immune checkpoint receptor that inhibits T-cell activation when bound by ligands including PD-L1/L2. PD-L1 overexpression has been noted on HCC tumors, and PD-1/PD-L1 interaction may contribute to viral hepatitis induced T-cell exhaustion. Nivolumab, a PD-1 receptor blocking antibody, has shown efficacy against various solid tumor types in Ph 1 trials. We hypothesized that blockade of PD-1/PD-L1 interaction could enhance T-cell activation and mediate antitumor and/or antiviral activity in HCC pts. We describe a phase I, dose-escalation study of nivolumab in advanced HCC pts. Methods: Successive pt cohorts with histologically confirmed advanced HCC with/without HBV or HCV infection (N=72 max) will be treated on 3 distinct arms with IV nivolumab at 0.3, 1 and 3.0 mg/kg (uninfected or HCV-infected pts) or 0.1, 0.3, 1 and 3.0 mg/kg (HBV-infected pts) every 2 weeks using a 3+3 escalation scheme. Pts must have progressive disease or intolerance after ≥1 line of therapy or have refused sorafenib treatment, and a Child-Pugh class A. HBV-infected pts must be receiving antiviral therapy (viral DNA &lt;100 IU/mL) for ≥3 months. Pts with brain metastasis, encephalopathy, prior/current ascites requiring paracentesis, history of recent variceal bleeding, active coinfection with HIV, or both HBV and HCV, or concurrent hepatitis D and HBV infection will be excluded. Primary endpoints include characterization of safety, tolerability, dose-limiting toxicities and maximum tolerated dose of nivolumab. Secondary endpoints include assessment of the preliminary antitumor activity (per modified RECIST for HCC), PK and immunogenicity. Exploratory endpoints include evaluation of the relationship between tumor PD-L1 expression and clinical outcome, and nivolumab’s antiviral and immunoregulatory activity in peripheral blood and/or tumor specimens. Clinical trial information: NCT01658878.
The C-terminal flavin domain of gp91phox bound to plasma membranes of granulocyte-like X-CGD PLB-985 cells is sufficient to anchor cytosolic oxidase components and support NADPH oxidase-associated diaphorase activity independent of cytosolic phospholipase A2 regulation (2006)

We have previously established a model of cytosolic phospholipase A(2) (cPLA(2))-deficient PLB-985 cells and demonstrated that cPLA(2)-generated arachidonic acid (AA) is essential for reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activation and NADPH-dependent diaphorase activity. The present study focuses on the C-terminal cytoplasmic domain of gp91(phox) (residues 283-570), which contains the NADPH binding and flavin adenine dinucleotide-reducing center, to determine if this portion is regulated by AA. The gp91(phox) C-terminal reductase domain was expressed in X-CGD PLB-985 cells lacking normal gp91(phox) (X-CGD PLB 91CT cells) and was detected in the plasma membrane. It appears to be bound electrostatically to the plasma membrane, as it is eluted by high salt. Permeabilized, granulocyte-like X-CGD PLB 91CT cells lacking cPLA(2) protein and activity, as well as AA release after stimulation, supported NADPH-dependent diaphorase activity after stimulation, similar to granulocyte-like X-CGD PLB 91CT cells. Normal translocation of p47(phox) and p67(phox) to the membrane fractions of both stimulated cell types indicated that the gp91(phox) C-terminal region is sufficient to anchor the cytosolic oxidase components to the membranes. cPLA(2) translocated to membranes and bound the assembled oxidase in granulocyte-like X-CGD PLB 91CT cells after stimulation. Therefore, the assembled membrane-bound oxidase complex encompassing the flavin domain of gp91(phox) provides a docking site for cPLA(2) but is not the site of AA-based regulation of oxidase activity.
Symbolic analysis techniques : applications to analog design automation (1998)

This timely, self-contained volume gathers information disseminated from journals, workshops, and conference proceedings to present the most recent and most important applications of symbolic analysis to analog circuit design. It features an in-depth tutorial introduction to the techniques and algorithms underlying modern symbolic analyzers, and includes exhaustive references at the end of each section
IsoTag™AAV: an innovative, scalable & non-chromatographic method for streamlined AAV manufacturing (2022)

Demand for gene therapies capable of treating previously inaccessible targets has risen precipitously in the past decade. Adeno-associated viruses (AAVs) are the preferred vector for gene delivery because of their favorable safety profile and tissue tropism, but they have significant manufacturing challenges, with end-to-end yields as low as 10-30%. To combat these low yields, we developed IsoTag<sup>™</sup>AAV, a novel purification technology for AAV that is a departure from the chromatographic paradigm in downstream processing. This proprietary technology uses a self-scaffolding recombinant protein reagent that can improve manufacturing yields. It enables purification by cost-effective and scalable filtration processes and improves product quality with minimal optimization. Herein, we describe the development of IsoTag<sup>™</sup>AAV, provide a head-to-head comparison to industry-leading affinity chromatography (evaluation carried out through a joint research project with Capsida Biotherapeutics), and demonstrate how it can reduce cost of goods for a clinical AAV program by 25%.
Polyclonal (2019)

Recommendations are given concerning the terminology of methods of bioanalytical chemistry. With respect to dynamic development particularly in the analysis and investigation of biomacromolecules, terms related to bioanalytical samples, enzymatic methods, immunoanalytical methods, methods used in genomics and nucleic acid analysis, proteomics, metabolomics, glycomics, lipidomics, and biomolecules interaction studies are introduced.
Correlating the excited state relaxation dynamics as measured by photoluminescence and transient absorption with the photocatalytic activity of Au@TiO2core–shell nanostructures (2012)

The spectroscopic and photocatalytic properties of a series of Au@TiO(2) core-shell nanostructures are characterized. The crystallinity of the TiO(2) shells was varied by changing the etching and calcination conditions. Measurements of the photoluminescence, transient absorption, and H(2) production rate permit us to look for correlations between the spectroscopic and catalytic behaviors. We found that there is a strong effect of crystallinity on the H(2) production rate and also the stretched exponential lifetime of the photoluminescence created by short-wavelength (266 and 300 nm) photoexcitation. As the TiO(2) crystallinity is increased, the photoluminescence lifetime increases from 22 to 140 ps in a 1 ns detection window, while the H(2) production rate increases by a factor of ~4. There is no discernible effect of crystallinity on the photoluminescence dynamics excited at 350 or 430 nm, or on the electronic dynamics measured by femtosecond transient absorption after excitation at 300 nm. We hypothesize that high-energy photons create reactive and emissive charge-separated states in parallel, and that both species are subject to similar electron-hole recombination processes that depend on sample crystallinity. Based on our observations, it can be concluded that the photoluminescence dynamics may be used to evaluate the potential performance of this class of photocatalysts.
Host-guest complexation. 41. Preorganization of a host enhances its binding of aryldiazonium salts (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHost-guest complexation. 41. Preorganization of a host enhances its binding of aryldiazonium saltsDonald J. Cram and Kenneth M. DoxseeCite this: J. Org. Chem. 1986, 51, 26, 5068–5071Publication Date (Print):December 1, 1986Publication History Published online1 May 2002Published inissue 1 December 1986https://pubs.acs.org/doi/10.1021/jo00376a004https://doi.org/10.1021/jo00376a004research-articleACS PublicationsRequest reuse permissionsArticle Views192Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Direct measurement of piezoelectric properties of Sol-Gel PZT films (1998)

PbZr0.53Ti0.47O3 films were deposited on Si-SiO2-Ta-Pt substrates via a conventional sol-gel procedure. Electrical properties of the films were: resistivity ca. 5 × 1011 Ωcm, relative dielectric permittivity 900-1100, remnant polarization ca. 20 μC/cm2, breakdown electric field larger than 50 MV/m. The deflection amplitude of piezoelectrically excited Si cantilevers, covered with SiO2-Ta-Pt-PZT-Al, was determined with the aid of a heterodyne Mach-Zehnder interferometer. The piezoelectric strain constant d31 of the PZT films was determined from the amplitude measured at frequencies far below the first mechanical resonance (quasi-static method). The d31 constant was also determined from the deflection amplitude at the first mechanical resonance and the quality factor of the cantilever. Measured values ranged from -30 pC/N for unpoled films to -160 pC/N for films poled at room temperature and 40 MV/m.
5,12‐Dialkyl‐5,12‐dihydroindolo[3,2‐a]carbazole‐Based Oxime‐Esters for LED Photoinitiating Systems and Application on 3D Printing (2022)

Abstract In order to expand the application of oxime‐esters (OXEs) and to introduce a one‐component photoinitiating system of high performance in visible light photopolymerization, a series of 5,12‐dialkyl‐5,12‐dihydroindolo[3,2‐a]carbazole‐based oxime‐esters with visible light absorption abilities is designed and synthesized. Notably, when irradiated with light‐emitting diodes at 405 nm, the proposed structures can undergo a direct cleavage of the NO bond followed by decarboxylation, generating free radicals capable to efficiently initiate free radical photopolymerizations (FRP). Furthermore, the new OXEs showed good thermal initiation abilities and can be used as dual photo and thermal initiators. An interesting structure/reactivity/efficiency relationship can be obtained by comparing the reactivity of the different radicals generated upon photoexcitation at identical chromophore but also by comparing the photoinitiating ability of the hexyl derivatives (1)–(10) with that of methyl derivatives (1′)–(10′) characterized by a lower solubility than the previous series in resins. Chemical mechanisms are studied through different techniques including real‐time Fourier transform infrared spectroscopy, UVvisible absorption spectroscopy, fluorescence (time‐resolved or steady‐state) as well as molecular modeling calculations. To finish, OXEs are incorporated in new photosensitive 3D printing resins, furnishing 3D objects with a remarkable spatial resolution.
Studies on pyrazines. Part 27. A new deoxidative nucleophilic substitution of pyrazine N-oxides; synthesis of azidopyrazines with trimethylsilyl azide (1994)

Azidopyrazines bearing amino, methoxy and/or phenyl groups have been synthesized by reaction of pyrazine N-oxides with trimethylsilyl azide in the presence of diethylcarbamoyl chloride in refluxing acetonitrile. In most cases, the azidation occurs only at the carbon α to the N-oxide function, and 3-substituted pyrazine 1-oxides gave 2-azido-3-substituted pyrazines. Conversely, methyl, chloro and methoxycarbonylpyrazine N-oxides did not undergo azidation. The electronic and steric effects of the substituent on the reactivity are discussed.
Preparation of Oligonucleotides Containing Non-natural Base Analogues (1995)

Abstract The preparation of a protected derivative of 2-aza- 2′-deoxyinosine carrying a photolabile protecting group is described. The new derivative is useful to prepare oligonucleotides containing 2-azahypoxanthine. The synthesis of oligonucleotides containing 2-fluorohypoxanthine and O4-alkylthymine is also described.
Ruthenium Catalyzed Hydrogenation of Aldehyde with Synthesis Gas (2014)

The hydrogenation of aldehyde utilizing synthesis gas as a dihydrogen source was examined with various ruthenium catalysts, among which Ru-cyclopentadienone complexes (Shvo-type catalysts) exhibited higher activity than others. DFT calculations proved that the exchange of coordinated carbon monoxide by dihydrogen is relatively preferable in Shvo-type catalysts compared to others, which is a pre-equilibrium for the generation of the hydrogenation-active species.
Acute Kidney Injury Risk Assessment: Differences and Similarities Between Resource-Limited and Resource-Rich Countries (2017)

The incidence of acute kidney injury (AKI) among acutely ill patients is reportedly very high and has vexing consequences on patient outcomes and health care systems. The risks and impact of AKI differ between developed and developing countries. Among developing countries, AKI occurs in young individuals with no or limited comorbidities, and is usually due to environmental causes, including infectious diseases. Although several risk factors have been identified for AKI in different settings, there is limited information on how risk assessment can be used at population and patient levels to improve care in patients with AKI, particularly in developing countries where significant health disparities may exist. The Acute Disease Quality Initiative consensus conference work group addressed the issue of identifying risk factors for AKI and provided recommendations for developing individualized risk stratification strategies to improve care. We proposed a 5-dimension, evidence-based categorization of AKI risk that allows clinicians and investigators to study, define, and implement individualized risk assessment tools for the region or country where they practice. These dimensions include environmental, socioeconomic and cultural factors, processes of care, exposures, and the inherent risks of AKI. We provide examples of these risks and describe approaches for risk assessments in the developing world. We anticipate that these recommendations will be useful for health care providers to plan and execute interventions to limit the impact of AKI on society and each individual patient. Using a modified Delphi process, this group reached consensus regarding several aspects of AKI risk stratification.
Tunable optical microwave bandpass filter with negative coefficients using an optical phase modulator and chirped fiber Bragg gratings (2007)

A novel approach to implementing a tunable optical microwave bandpass filter with positive and negative coefficients based on an optical phase modulator and chirped fiber Bragg gratings is proposed and experimentally demonstrated. The positive and negative coefficients are generated through optical phase-modulation to intensity-modulation (PM-IM) conversion using linearly chirped fiber Bragg gratings (LCFBGs) with opposite dispersions. By changing the wavelength of the optical carrier within the chirp range of the LCFBGs, the tunability of the filter response is realized. A two-tap tunable microwave bandpass filter is experimentally demonstrated.
Optimization Strategies for DNA Vaccines (2000)

DNA immunization is a relatively new vaccination strategy that involves the direct introduction into the host of plasmid DNA encoding the desired antigen. The DNA enters host cells and results in immune responses following in vivo expression of the antigen. Although DNA-based immunization works well in animal models for the induction of both humoral and cell-mediated immune responses, its success in humans has been limited. This paper discusses different approaches that have attempted to optimize DNA vaccines, and presents results evaluating some of these approaches in mice.
The tetraamine chelator outperforms HYNIC in a new technetium-99m-labelled somatostatin receptor 2 antagonist (2018)

These data indicate a very promising <sup>99m</sup>Tc-labelled sst2-targeting antagonist. The results demonstrate high sensitivity of the <sup>99m</sup>Tc-labelling strategy, which was shown to strongly influence the receptor affinity, contrary to corresponding agonists. <sup>99m</sup>Tc-SS-04 exhibits excellent pharmacokinetics and imaging properties and appears to be a suitable candidate for SPECT/CT clinical translation.
Distributed optimal load shedding for disaster recovery in smart electric power grids (2014)

In this paper, we consider the problem of distributed load shedding optimization for disaster recovery in smart grids. We develop distributed second-order interior-point based load shedding algorithms that enjoy a fast quadratic convergence rate. Our main contributions are two-fold: (i) We propose a rooted spanning tree based reformulation that enables our distributed algorithm design; (ii) Based on the spanning tree reformulation, we design distributed computation schemes for our proposed second-order interior-point based load shedding. Collectively, these results serve as an important first step in load shedding and disaster recovery that uses second-order distributed techniques.
Spindling artifact of urothelial cells in post‐laser treatment urinary cytology (1993)

We reviewed 22 post-laser (Nd:YAG laser) coagulation bladder washes collected immediately after treatment. All washes demonstrated a striking artifact of cellular spindling. These spindled cells occurred singly, in loose clusters, and in lamellar stacks and had elongated nuclei with dense chromatin and bipolar cytoplasm that was fused in the stacks. Concurrent biopsies demonstrated similar cytologic changes. The spindling is a nonspecific epithelial response to heat. Conventionally electrocauterized epithelia show this artifact in biopsies, but since only the base of the lesion and surrounding urothelium are subjected to heat with electrocautery, the relatively few spindled epithelial cells created presumably go undetected in cytology specimens. With laser treatment, however, the whole urothelial surface of the lesion is coagulated, producing a much greater number of spindled cells. It is important to avoid misinterpreting the spindled cells as cells from a mesenchymal neoplasm or a sarcomatoid carcinoma, mistakes that were made in some of our initial cases. Malignancy cannot be evaluated when cells exhibit spindling artifact; this judgement should be made on undistorted cells. Thus, pre-laser and post-laser washes should be submitted for evaluation of malignancy.
Backscatter measurements using side-looking sonar (1976)

Signals from a 110-kHz side-looking sonar have been digitally processed in real time to remove the variations due to small-scale vehicle motions and transducer beam pattern. The residual signals can be used to measure the backscattering coefficient of the ocean bottom at grazing angles from 45° down to 6°. The system is calibrated by use of a cross-frequency reference transponder. Data have been gathered in several areas of the Eastern Pacific and in the North Atlantic. [Work supported by U.S. Navy.]