gebhart/patrepeval huggingface dataset:
Gender-related differences in irritable bowel syndrome: Potential mechanisms of sex hormones (2014)

According to epidemiological studies, twice as many women as men are affected by irritable bowel syndrome (IBS) in western countries, suggesting a role for sex hormones in IBS pathophysiology. Despite growing evidence about the implications of sex hormones in IBS symptom modulation, data on mechanisms by which they influence disease development are sparse. This review aims to determine the state of knowledge about the role of sex hormones in sensorimotor dysfunctions and to address the possible interplay of sex hormones with common risk factors associated with IBS. The scientific bibliography was searched using the following keywords: irritable bowel syndrome, sex, gender, ovarian hormone, estradiol, progesterone, testosterone, symptoms, pain, sensitivity, motility, permeability, stress, immune system, brain activity, spinal, supraspinal, imaging. Ovarian hormones variations along the menstrual cycle affect sensorimotor gastrointestinal function in both healthy and IBS populations. They can modulate pain processing by interacting with neuromodulator systems and the emotional system responsible for visceral pain perception. These hormones can also modulate the susceptibility to stress, which is a pivotal factor in IBS occurrence and symptom severity. For instance, estrogen-dependent hyper-responsiveness to stress can promote immune activation or impairments of gut barrier function. In conclusion, whereas it is important to keep in mind that ovarian hormones cannot be considered as a causal factor of IBS, they arguably modulate IBS onset and symptomatology. However, our understanding of the underlying mechanisms remains limited and studies assessing the link between IBS symptoms and ovarian hormone levels are needed to improve our knowledge of the disease evolution with regard to gender. Further studies assessing the role of male hormones are also needed to understand fully the role of sex hormones in IBS. Finally, investigation of brain-gut interactions is critical to decipher how stress, ovarian hormones, and female brain processing of pain can translate into gut dysfunctions.
Effectiveness of 3-Aminopropyl-Triethoxy-Silane as a Coupling Agent for Phosphate Glass Fiber-Reinforced Poly(caprolactone)-based Composites for Fracture Fixation Devices (2011)

Silane (3-Aminopropyl-triethoxy-silane) solutions with differing concentrations (0—10 wt%) were prepared from an aqueous ethanol solution (90% ethanol + 10% deionized water, by volume). Phosphate glass fibers were immersed in these silane solutions for time periods between 15 and 120 min. It was found that the silane treatment yielded fiber mass gains and it was noted that shorter immersion times resulted in higher mass additions. The largest gain in mass was observed for 10 wt% silane treatment and 15 min immersion time, with the fibers gaining 4.1 wt%. Subsequent XPS confirmed the presence of silane at the surface of the fibers. Poly(caprolactone)-based unidirectional composites were made by compression molding. The tensile and the bending properties of the silane composites improved significantly. Composites made with fibers treated with 10 wt% silane had 47% higher tensile strength and 86% higher tensile modulus than those of the untreated fiber-based composite control specimens. The bending properties also proved superior to the control composite (52% higher bending strength and 79% higher bending modulus). Degradation tests of the composites were carried out in deionised water at 37°C and found that silane-based composites retained higher tensile and bending properties than their untreated counterparts.
Diagnostic value of anti-neuronal antibodies for paraneoplastic disorders of the nervous system. (1990)

The diagnostic value of the presence of anti-neuronal antibodies in serum was examined in 21 patients suspected of paraneoplastic disorders of the nervous system (NS) (group 1) and was compared to three control groups; group 2: 25 patients with a neurological disease, without cancer and no sign of paraneoplastic disorder; group 3: 27 patients with neurological disease and cancer and no signs of a paraneoplastic disorder; group 4: 94 patients with cancer and without neurological disease. In group 1, anti-neuronal nuclear antibodies were detected in eight patients (38%), in titres from 1:1000 to 1:32,000. A small cell lung cancer was present in six patients, ovarian cancer in one patient and in one patient no tumour could be detected. The neurological symptoms preceded a diagnosis of cancer in five out of eight patients. Anti-neuronal antibodies were found in the serum of two out of 94 patients (2%) from control group 3 but not in serum from any of the other control groups. These data indicate a moderate sensitivity of 38%, but a high specificity of 98.6% (95% confidence interval 95.5-99.8%) for the presence of anti-neuronal nuclear antibodies if a paraneoplastic NS disorder is suspected.
Acetyl-CoA Carboxylase in Higher Plants: Most Plants Other Than Gramineae Have Both the Prokaryotic and the Eukaryotic Forms of This Enzyme (1996)

The presence and the absence of a prokaryote type and a eukaryote type of acetyl-CoA carboxylase (EC 6.4.1.2; ACCase) were examined in members of 28 plant families by two distinct methods: the detection of biotinylated subunits of ACCase with a streptavidin probe, and the detection of the accD gene, which encodes a subunit of the prokaryotic ACCase, by Southern hybridization analysis. The protein extracts of all the plants studied contained a biotinylated polypeptide of 220 kDa, which was probably the eukaryotic ACCase. All the plants but those belonging to Gramineae also contained a biotinylated polypeptide of ca. 35 kDa, which is a putative subunit of the prokaryotic ACCase. In all plants but those in Gramineae, the ca. 35 kDa polypeptide was found in the protein extracts of plastids, while the 220 kDa polypeptide was absent from these plastid extracts. The plastid extracts of the plants in Gramineae contained the 220 kDa polypeptide, as did the homogenates of the leaves. Southern hybridization analysis demonstrated that all the plants but those in the Gramineae contained the accD gene. These findings suggest that most higher plants have the prokaryotic ACCase in the plastids and the eukaryotic ACCase in the cytosol. Only Gramineae plants might contain the eukaryotic ACCases both in the plastids and in the cytosol. The origin of the plastid-located eukaryotic ACCase in Gramineae is discussed as the first possible example of substitution of a plastid gene by a nuclear gene for a non-ribosomal component.
Effects of chronic activation of peroxisome proliferator-activated receptor-α or high-fat feeding in a rat infarct model of heart failure (2005)

Intracardiac accumulation of lipid and related intermediates (e.g., ceramide) is associated with cardiac dysfunction and may contribute to the progression of heart failure (HF). Overexpression of nuclear receptor peroxisome proliferator-activated receptor-alpha (PPARalpha) increases intramyocellular ceramide and left ventricular (LV) dysfunction. We tested the hypothesis that activation of fatty acid metabolism with fat feeding or a PPARalpha agonist increases myocardial triglyceride and/or ceramide and exacerbates LV dysfunction in HF. Rats with infarct-induced HF (n = 38) or sham-operated rats (n = 10) were either untreated (INF, n = 10), fed a high-fat diet (45% kcal fat, INF + Fat, n = 15), or fed the PPARalpha agonist fenofibrate (150 mg.kg(-1).day(-1), INF + Feno, n = 13) for 12 wk. LV ejection fraction was significantly reduced with HF (49 +/- 6%) compared with sham operated (86 +/- 2%) with no significant differences in ejection fraction (or other functional or hemodynamic measures) among the three infarcted groups. Treatment with the PPARalpha agonist resulted in LV hypertrophy (24% increase in LV/body mass ratio) and induced mRNAs encoding for PPARalpha-regulated genes, as well as protein expression and activity of medium chain acyl-CoA dehydrogenase (compared with INF and INF + Fat groups). Myocardial ceramide content was elevated in the INF group compared with sham-operated rats, with no further change in the INF + Fat or INF + Feno groups. Myocardial triglyceride was unaffected by infarction but increased in the INF + Fat group. In conclusion, LV dysfunction and dilation are not worsened despite upregulation of the fatty acid metabolic pathway and LV hypertrophy or accumulation of myocardial triglyceride in the rat infarct model of HF.
Experimental investigation of water distribution in a two-phase zone during gravity-dominated evaporation (2017)

We characterize the water repartition within the partially saturated (two-phase) zone (PSZ) during evaporation from mixed wettable porous media by controlling the wettability of glass beads, their sizes, and as well the surrounding relative humidity. Here, capillary numbers are low and under these conditions, the percolating front is stabilized by gravity. Using experimental and numerical analyses, we find that the PSZ saturation decreases with the Bond number, where packing of smaller particles have higher saturation values than packing made of larger particles. Results also reveal that the extent (height) of the PSZ, as well as water saturation in the PSZ, both increase with wettability. We also numerically calculate the saturation exclusively contained in connected liquid films and results show that values are less than the expected PSZ saturation. These results strongly reflect that the two-phase zone is not solely made up of connected capillary networks but also made of disconnected water clusters or pockets. Moreover, we also find that global saturation (PSZ + full wet zone) decreases with wettability, confirming that greater quantity of water is lost via evaporation with increasing hydrophilicity. These results show that connected liquid films are favored in more-hydrophilic systems while disconnected water pockets are favored in less-hydrophilic systems.
Optics of Quantum Dots and Wires (2004)

The Optics of Quantum Wires and Dots: An Introduction. Carrier Relaxation in Nanostructures and Its Implication for Optical Properties. Optical Properties of Quantum Dots Induced by Self-Assembled Stressors. Novel Lateral Semiconductor Nanostructures Grown on Nonplanar Substrates by Organometallic Chemical Vapor Deposition. Optical Properties and Lasing in Self-Organized Quantum Dots. High-Resolution Spectroscopy of Quantum Dots. Quantum Dot Diodes. Dots As Single Photon Sources.
Bone Formation by Sheep Stem Cells in an Ectopic Mouse Model: Comparison of Adipose and Bone Marrow Derived Cells and Identification of Donor‐Derived Bone by Antibody Staining (2016)

<i>Background</i>. Scaffolds for bone tissue engineering (BTE) can be loaded with stem and progenitor cells (SPC) from different sources to improve osteogenesis. SPC can be found in bone marrow, adipose tissue, and other tissues. Little is known about osteogenic potential of adipose-derived culture expanded, adherent cells (A-CEAC). This study compares <i>in vivo</i> osteogenic capacity between A-CEAC and bone marrow derived culture expanded, adherent cells (BM-CEAC). <i>Method</i>. A-CEAC and BM-CEAC were isolated from five female sheep and seeded on hydroxyapatite granules prior to subcutaneous implantation in immunodeficient mice. The doses of cells in the implants were 0.5 × 10<sup>6</sup>, 1.0 × 10<sup>6</sup>, or 1.5 × 10<sup>6</sup> A-CEAC and 0.5 × 10<sup>6</sup> BM-CEAC, respectively. After eight weeks, bone volume versus total tissue volume (BV/TV) was quantified using histomorphometry. Origin of new bone was assessed using human vimentin (HVIM) antibody staining. <i>Results</i>. BM-CEAC yielded significantly higher BV/TV than any A-CEAC group, and differences between A-CEAC groups were not statistically significant. HVIM antibody stain was successfully used to identify sheep cells in this model. <i>Conclusion</i>. A-CEAC and BM-CEAC were capable of forming bone, and BM-CEAC yielded significantly higher BV/TV than any A-CEAC group. <i>In vitro</i> treatment to enhance osteogenic capacity of A-CEAC is suggested for further research in ovine bone tissue engineering.
An Enhanced Drought-Tolerant Method Using SA-Loaded PAMPS Polymer Materials Applied on Tobacco Pelleted Seeds (2014)

Drought is one of the most important stress factors limiting the seed industry and crop production. Present study was undertaken to create novel drought-resistant pelleted seeds using the combined materials with superabsorbent polymer, poly(2-acrylamide-2-methyl propane sulfonic acid) (PAMPS) hydrogel, and drought resistance agent, salicylic acid (SA). The optimized PAMPS hydrogel was obtained as the molar ratio of 2-acrylamido-2-methyl-propanesulfonic acid (AMPS) to potassium peroxydisulfate (KPS) and N, N'-methylene-bis-acrylamide (MBA) was 1 : 0.00046 : 0.00134. The hydrogel weight after swelling in deionized water for 24 h reached 4306 times its own dry weight. The water retention ratio (RR) of PAMPS was significantly higher as compared with the control. It could keep as high as 85.3% of original weight after 30 min at 110 °C; even at 25 °C for 40 d, the PAMPS still kept RR at 33.67%. PAMPS disintegration ratio increased gradually and reached around 30% after embedding in soil or activated sludge for 60 d. In addition, there were better seed germination performance and seedling growth in the pelleted treatments with SA-loaded PAMPS hydrogel under drought stress than control. It suggested that SA-loaded PAMPS hydrogel, a nontoxic superabsorbent polymer, could be used as an effective drought resistance material applied to tobacco pelleted seeds.
New Compounds. Synthesis of Some New N-o-Tolyl-N'-2-(substituted) Benzothiazolylguanidines (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew Compounds. Synthesis of Some New N-o-Tolyl-N'-2-(substituted) BenzothiazolylguanidinesP Bhargava and Harihar SinghCite this: J. Med. Chem. 1969, 12, 3, 558–559Publication Date (Print):May 1, 1969Publication History Published online23 September 2003Published inissue 1 May 1969https://pubs.acs.org/doi/10.1021/jm00303a638https://doi.org/10.1021/jm00303a638research-articleACS PublicationsRequest reuse permissionsArticle Views33Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Antiarthritic and supressor cell inducing activity of azaspiranes: structure-function relationships of a novel class of immunomodulatory agents (1990)

Spirogermanium (1; 8,8-diethyl-N,N-dimethyl-2-aza-8- germaspiro[4.5]decane-2-propanamine dihydrochloride) is a potent cytotoxic agent in vitro which has demonstrated limited activity in experimental animal tumor models. Subsequently, it has been reported that spirogermanium has antiarthritic and suppressor cell-inducing activity. We have synthesized a series of substituted 8-hetero-2-azaspiro[4.5]decane and 9-hetero-3-azaspiro[5.5]undecane analogues of spirogermanium to identify the heteroatom requirements for in vivo antiarthritic and suppressor cell-inducing activity. This structure-activity relationship study has identified that appropriately substituted silicon and carbon analogues of spirogermanium retain both antiarthritic and immunosuppressive activity, with the 8,8-dipropyl (carbon) analogue being among the most active. Following the identification of N,N-dimethyl-8,8-dipropyl-2-azaspiro[4.5]decane-2-propanamine++ + dihydrochloride (9) as a more active analogue than spirogermanium, a series of 8,8-dipropyl analogues with various amine substituents were synthesized. A number of these analogues had activity similar to that of 9. A correlation between activity in the adjuvant arthritic rat and the ability to induce suppressor cells (r = 0.894, p less than 0.001) suggests an association between the two pharmacologic effects. While the precise biochemical mechanism(s) for the pharmacological activity is unclear, these data suggest that compounds within this series, e.g., N,N-dimethyl-8,8-dipropyl-2-azaspiro[4.5]decane-2-propanamine++ + dihydrochloride, may provide effective therapy in diseases of autoimmune origin and/or the prevention of rejection in tissue transplantation.
Thermo-Fluid Study of the UPC Race-Track Microtron Cooling System (2017)

The cooling system of the race-track microtron (RTM), which is under construction at the Universitat Politècnica de Catalunya (UPC), has been simulated by means of a computational fluid dynamics (CFD) software. The hydraulic and thermal performance of the system has been studied for various operation conditions. Firstly, the hydraulic model has been validated by comparison with experimental measurements at different flow rates. Then, the cooling fluid temperatures and the pressure losses of the system have been determined and the capacity of the current design to remove the generated heat at nominal power has been confirmed. Finally, the wall maximum and average temperatures and heat transfer coefficients inside the magnets and the accelerating structure have been calculated. These results have allowed us to localize sections of the cooling system with a low convection due to detached flows where, therefore, a risk of zones of high temperatures exists. An optimization of the cooling circuit with the aim to reduce such high temperature zones has been proposed.
Rayleigh-Brillouin Light Scattering: Spectral Moments and Sum Rules (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRayleigh-Brillouin Light Scattering: Spectral Moments and Sum RulesR. P. C. Schram, G. H. Wegdam, and Arjen BotCite this: J. Phys. Chem. 1994, 98, 12, 3139–3147Publication Date (Print):March 1, 1994Publication History Published online1 May 2002Published inissue 1 March 1994https://pubs.acs.org/doi/10.1021/j100063a016https://doi.org/10.1021/j100063a016research-articleACS PublicationsRequest reuse permissionsArticle Views83Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Supplementary Table and Figure from Molecular Pathways: Interferon/Stat1 Pathway: Role in the Tumor Resistance to Genotoxic Stress and Aggressive Growth (2023)

&lt;p&gt;PDF file - 75K, ISGs associated with genotoxic stress&lt;/p&gt;
Contribution of intermediate filaments to cell stiffness, stiffening, and growth (2000)

It has been shown previously that intermediate filament (IF) gels in vitro exhibit stiffening at high-applied stress, and it was suggested that this stiffening property of IFs might be important for maintaining cell integrity at large deformations (Janmey PA, Evtenever V, Traub P, and Schliwa M, J Cell Biol 113: 155-160, 1991). In this study, the contribution of IFs to cell mechanical behavior was investigated by measuring cell stiffness in response to applied stress in adherent wild-type and vimentin-deficient fibroblasts using magnetic twisting cytometry. It was found that vimentin-deficient cells were less stiff and exhibited less stiffening than wild-type cells, except at the lowest applied stress (10 dyn/cm(2)) where the difference in the stiffness was not significant. Similar results were obtained from measurements on wild-type fibroblasts and endothelial cells after vimentin IFs were disrupted by acrylamide. If, however, cells were plated over an extended period of time (16 h), they exhibited a significantly greater stiffness before than after acrylamide, even at the lowest applied stress. A possible reason could be that the initially slack IFs became fully extended due to a high degree of cell spreading and thus contributed to the transmission of mechanical stress across the cell. Taken together, these findings were consistent with the notion that IFs play important roles in the mechanical properties of the cell during large deformation. The experimental data also showed that depleting or disrupting IFs reduced, but did not entirely abolish, cell stiffening. This residual stiffening might be attributed to the effect of geometrical realignment of cytoskeletal filaments in the direction of applied load. It was also found that vimentin-deficient cells exhibited a slower rate of proliferation and DNA synthesis than wild-type cells. This could be a direct consequence of the absence of the intracellular IFs that may be necessary for efficient mediation of mechanical signals within the cell. Taken together, results of this study suggest that IFs play important roles in the mechanical properties of cells and in cell growth.
Production and characterization of spiral phase plates for optical wavelengths (2004)

We describe the fabrication and characterization of a high-quality spiral phase plate as a device to generate optical vortices of low (3-5) specified charge at visible wavelengths. The manufacturing process is based on a molding technique and allows for the production of high-precision, smooth spiral phase plates as well as for their replication. An attractive feature of this process is that it permits the fabrication of nominally identical spiral phase plates made from different materials and thus yielding different vortex charges. When such a plate is inserted in the waist of a fundamental Gaussian beam, the resultant far-field intensity profile shows a rich vortex structure, in excellent agreement with diffraction calculations based on ideal spiral phase plates. Using a simple optical test, we show that the reproducibility of the manufacturing process is excellent.
Discrete logarithm computations over finite fields using Reed-Solomon codes (2012)

Cheng and Wan have related the decoding of Reed-Solomon codes to the computation of discrete logarithms over finite fields, with the aim of proving the hardness of their decoding. In this work, we experiment with solving the discrete logarithm over GF(q^h) using Reed-Solomon decoding. For fixed h and q going to infinity, we introduce an algorithm (RSDL) needing O (h! q^2) operations over GF(q), operating on a q x q matrix with (h+2) q non-zero coefficients. We give faster variants including an incremental version and another one that uses auxiliary finite fields that need not be subfields of GF(q^h); this variant is very practical for moderate values of q and h. We include some numerical results of our first implementations.