gebhart/patrepeval huggingface dataset:
Non-penetrating deep sclerectomy for glaucoma surgery using the femtosecond laser: a laboratory model (2007)

Non-penetrating deep sclerectomy (NPDS) is a non-perforating filtration procedure used for the surgical treatment of medically uncontrolled open angle glaucoma. This procedure was developed in an attempt to avoid many of the postoperative complications of trabeculectomy.1 The major advantage of NPDS is that it precludes the sudden hypotony that occurs after trabeculectomy by creating progressive filtration of aqueous humour from the anterior chamber to the subconjunctival space, without perforating the eye.2 Preservation of the thin trabeculo-Descemet’s membrane, however, is technically challenging, particularly before the surgeon gains experience with this procedure.

Previous studies investigated the ability to use the femtosecond laser for photodisruption in the human sclera,3 4 and concluded that complete subsurface photodisruption can be accomplished in human sclera in vitro .

Toyran et al. 5 in 2005 published their in-vitro study that tested the feasibility of using femtosecond laser pulses to fistulise the human trabecular meshwork and concluded that, with appropriate exposure time and pulse energy, femtosecond photodisruption can be employed to create partial …
Identification of CRKII, CFL1, CNTN1, NME2, and TKT as Novel and Frequent T-Cell Targets in Human IDH-Mutant Glioma (2018)

<b>Purpose:</b> Successful immunotherapies for IDH<sup>mut</sup> gliomas require better knowledge of T-cell target antigens. Here, we elucidated their antigen repertoire recognized by spontaneous T-cell responses using an unbiased proteomic approach.<b>Experimental Design:</b> Protein fractionations of tissue lysates from IDH<sup>mut</sup> gliomas (<i>n</i> = 4) were performed. Fractions were tested by IFNγ ELISpot assay for recognition through patients' T cells. Proteins of immunogenic fractions were identified by mass spectrometry and validated by <i>in silico</i>-predicted synthetic long peptides in patients of origin, additional IDH<sup>mut</sup> glioma patients (<i>n</i> = 16), and healthy donors (<i>n</i> = 13). mRNA and protein expression of immunogenic antigens was analyzed in tumor tissues and IDH<sup>mut</sup> glioma stem-like cells (GSC). HLA-A*02-restricted T-cell epitopes were functionally determined by short peptides and numbers of antigen-specific T cells by HLA-peptide tetramer analysis.<b>Results:</b> A total of 2,897 proteins were identified in immunogenic tumor fractions. Based on a thorough filter process, 79 proteins were selected as potential T-cell antigens. Twenty-six of these were recognized by the patients' T cells, and five of them (CRKII, CFL1, CNTN1, NME2, and TKT) in up to 56% unrelated IDH<sup>mut</sup> glioma patients. Most immunogenic tumor-associated antigens (TAA) were expressed in IDH<sup>mut</sup> gliomas and GSCs, while being almost absent in normal brain tissues. Finally, we identified HLA-A*02-restricted epitopes for CRKII, NME2, and TKT that were recognized by up to 2.82% of antigen-specific peripheral cytotoxic T cells in IDH<sup>mut</sup> glioma patients.<b>Conclusions:</b> By analyzing the repertoire of T-cell target antigens in IDH<sup>mut</sup> glioma patients, we identified five novel immunogenic TAAs and confirmed their expression on IDH<sup>mut</sup> tumors and GSCs. <i>Clin Cancer Res; 24(12); 2951-62. ©2018 AACR</i>.
Far-infrared transmission of superconductingKxC60films (1992)

Far-infrared transmission measurements have been performed on normal and superconducting ${\mathrm{K}}_{\mathit{x}}$${\mathrm{C}}_{60}$ films on Si substrates. The films are prepared by thermal sublimation followed by in situ doping in a vacuum-tight cell. The observed peak in the ratio of the superconducting to normal transmittance near 50 ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}1}$ is consistent with a distribution of superconducting gaps in the range (2--5)${\mathit{kT}}_{\mathit{c}}$.
Prediction of permanent deformation model parameters of unbound base course aggregates under repeated loading (2015)

Prediction of rutting is a key element in the newly developed mechanistic-empirical pavement design guide (M-EPDG). The model developed by Tseng and Lytton (1989. Prediction of permanent deformation in flexible pavement materials. ASTM STP 1016, pp. 154–172: American Society for Testing and Materials) is used in the M-EPDG to estimate the permanent deformation of unbound materials, but does not predict parameters of the model satisfactorily. This research was conducted to study the effect of water content on permanent deformation model parameters of unbound aggregate base layers. Different aggregates were compacted at different water contents and were subjected to repeated loading tests. For the material tested, the permanent deformation increases rapidly when the water content exceeds that of the optimum. Under optimum water content, wopt, limestone is more resistant to permanent deformation than basalt and quartzite. However, above wopt, the permanent deformations of limestone grow rapidly and become higher than those of Basalt. This indicates a high sensitivity of limestone to water content, which increases the plastic deformation. An exponential relationship is more appropriate to describe the evolution of permanent deformation as a function of water content and gives a higher coefficient of determination. Assuming that the rutting parameters decrease exponentially with increasing water content, empirical relationships are proposed for predicting these parameters. These results should be used for further development of the M-EPDG rutting model.
Bimodal Effects of Neuropeptide Y on Hypothalamic Release of Gonadotropin-Releasing Hormone in Conscious Rabbits (1987)

Neuropeptide Y (NPY) is present in large quantities in the hypophysiotropic areas of the brain and has a similar distribution pattern as gonadotropin-releasing hormone (GnRH). The aim of this study was to measure GnRH release during perfusion of NPY through the mediobasal hypothalamus of intact and ovariectomized (OVEX) does. Does were fitted with push-pull (PP) cannulae directed into the median eminence and were subjected to subsequent PP perfusion at a flow rate of 20 microliters/min for a total of 6 or 8 h. Six intact does and seven OVEX does received intrahypothalamic perfusion of NPY (14 micrograms/ml) for either 2 or 3.5 h during the 6 or 8 h, respectively, of PP perfusion. The PP samples and femoral vein blood samples were collected at 10-min intervals on ice. Perfusate GnRH and plasma luteinizing hormone (LH), follicle-stimulating hormone (FSH), and prolactin (PRL) levels were measured by specific radioimmunoassays. The pulsatile parameters of all hormones were analyzed by the 'PULSAR' program. Perfusion of NPY significantly decreased mean levels, pulse amplitudes, and pulse frequencies of GnRH in OVEX does. Also, mean levels of LH were decreased, whereas levels of FSH and PRL were unaffected by NPY. In contrast to these inhibitory effects on GnRH in OVEX does, the same NPY perfusion stimulated mean levels and pulse amplitudes of GnRH in intact does. Plasma levels of neither gonadotropin nor PRL were affected significantly by the NPY treatment in intact rabbits. These results indicate that NPY may have central effects on neuronal release of GnRH, and that ovarian factors are critical in the directional mode of these NPY actions.
Activated Carbon Surface Modifications by Nitric Acid, Hydrogen Peroxide, and Ammonium Peroxydisulfate Treatments (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTActivated Carbon Surface Modifications by Nitric Acid, Hydrogen Peroxide, and Ammonium Peroxydisulfate TreatmentsC. Moreno-Castilla, M. A. Ferro-Garcia, J. P. Joly, I. Bautista-Toledo, F. Carrasco-Marin, and J. Rivera-UtrillaCite this: Langmuir 1995, 11, 11, 4386–4392Publication Date (Print):November 1, 1995Publication History Published online1 May 2002Published inissue 1 November 1995https://pubs.acs.org/doi/10.1021/la00011a035https://doi.org/10.1021/la00011a035research-articleACS PublicationsRequest reuse permissionsArticle Views6222Altmetric-Citations476LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Understanding bone-conduction hearing: Measurements and model development (2017)

Bone conduction (BC), the transmission of sound to the inner ear by way of skull vibration, is thought to stimulate the inner ear by several mechanisms: external ear (vibration of the ear-canal walls), middle ear (ossicular inertia), and inner ear (inertia of the cochlear fluids, compression of the cochlear walls, and sound flow through “third windows”). In chinchilla, we explore the inner-ear mechanisms with measurements of compound action potentials and intra-cochlear sound pressures after manipulations of the middle and inner ear. These measurements suggest that while contribution of cochlear fluid inertia to BC is reduced by occlusion of both cochlear windows, effects of cochlear compression and/or sound pressure transmission via “third window” pathways increase. We also explore external-ear mechanisms by applying an analytically-derived reverse input impedance of the external-ear canal, pre-existing measurements of middle-ear input impedance, and new measurements of ear canal sound pressure. We define an equivalent volume velocity source representative of the combined BC external-ear mechanisms. Estimates of the source magnitude are in agreement with experimental data (Chhan et al., 2016), showing that during ear-canal occlusion, the ear-canal source is a significant contributor to BC hearing at mid-frequencies (1-3 kHz).
Design and implementation of high-speed asynchronous communication ports for VLSI multicomputer nodes (2003)

The authors present the design of synchronizing communication ports for a communication coprocessor chip. These ports minimize the probability of synchronization failure and support communication at a very high rate relative to the limits of the implementation technology. The scheme presented does not require any lines in the link in addition to the data lines and does not require byte-per-byte handshaking. The design includes a synchronizer and a high-performance FIFO (first-in, first-out) buffer. This design is particularly well-suited for VLSI implementation and, for a given technology, can support higher communication speeds than previous synchronizer designs.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Analysis of a novel active capacitance circuit using BJT and its application to RF bandpass filters (2005)

This paper presents a novel active capacitance circuit using BJT and RLC series-feedback. It is competitive in the noise performance and the stability by adjusting the feedback elements. We analyze its characteristics in detail and apply it to an RF application by designing a duplexer. The active capacitance circuit can replace the passive capacitors of resonators in Rx and Tx BPF, which provide negative resistance to compensate for parasitic resistance of inductors. With the detailed analysis, we can obtain the frequency range as well as the maximum value of negative resistance. The active duplexer is designed realized at cellular at Rx (824/spl sim/849 MHz) and Tx (869/spl sim/894 MHz) bands.
Quantitative Relation between Surface Active Properties and Antibiotic Activity of 1-Alkyl-3-alkylthiomethylimidazolium Chlorides. (1995)

The critical micelle concentration (CMC) values were determined by surface tensiometry, and the hydrophobicity index (HI) was calculated. The quantitative relation between the minimum inhibitory concentration (MIC) and the CMC, and the HI was calculated.
Evaluation of the 0.3 logits screening criterion in common item equating. (2004)

A number of state assessment programs that employ Rasch-based common item equating procedures estimate the equating constant with only those common items for which the two tests' Rasch item difficulty parameter estimates differ by less than 0.3 logits. The results of this study presents evidence that this practice results in an inflated probability of incorrectly dropping an item from the common item set if the number of examinees is small (e.g., 500 or less) and the reverse if the number of examinees is large (e.g., 5000 or more). An asymptotic experiment-wise error rate criterion was algebraically derived. This same criterion can also be applied to the Mantel-Haenszel statistic. Bonferroni test statistics were found to provide excellent approximations to the (asymptotically) exact test statistics.
Exploring the Feasibility of Using Airport Data in Real-Time Risk Assessment (2013)

The effect of reduction of visibility on crash occurrence has recently been a major concern. Although visibility detection systems can help to mitigate the increased hazard of limited-visibility, such systems are not widely implemented and many locations with no systems are experiencing considerable number of fatal crashes due to reduction in visibility caused by fog and inclement weather. On the other hand, airports’ weather stations continuously monitor all climate parameters in real-time, the gathered data may be utilized to mitigate the increased risk for the adjacent roadways. This study aims to examine the viability of using airport weather information in real-time risk assessment in locations with recurrent fog problems. Bayesian logistic regression was utilized to link 6-years (2005-2010) of historical crash data to real-time weather information collected from 8 airports in the State of Florida, roadway characteristics and aggregate traffic parameters. The results from this research depicts that real-time weather data collected from adjacent airports are good predictors to assess increased risk on highways.
Abstractions for effectively portable shared memory parallel programs (1990)

In parallel programming there is a tension between software development costs and software performance. Portable languages and systems offer a solution to high software development costs, but performance typically suffers. Programmers unwilling to sacrifice performance must generally pay the higher cost of writing code fine-tuned for each architecture.
This dissertation presents a solution to the cost-performance tradeoff. The solution takes the form of a programming model and system, called Chameleon, supporting the development and execution of effectively portable parallel programs. An effectively portable program runs well across a class of parallel architectures while incurring low software development costs. Although it may give up a little in each of the cost and performance dimensions, the effectively portable program scores a commendable placing in both.
The Chameleon model consists of primitives of a sequential language and a set of abstract interfaces. The key to the model is that a select set of its interfaces abstract activities critical to performance; activities whose most efficient implementations can differ on the basis of the algorithm, multiprocessor, and runtime values of execution. Low software development cost is attained by writing source programs in terms of the model's interfaces, thereby requiring minimal modification to port; high performance is attained by the Chameleon runtime system matching the interfaces to the most appropriate library implementations for the current execution environment. Data-representation and partitioning-scheduling are two key abstractions of the model and system.
The work focusses on the use of uniform memory access (UMA) and non-uniform memory access (NUMA) shared memory multiprocessors in solving interval (array-oriented) and dynamic tree computations. An important feature of both model and system is the extensibility of each. The dissertation illustrates how the hierarchical organization and definition of open interfaces in the model and system foster enhancements through inheritance. The abstractions, in addition to providing effective portability, provide the parallel programmer with a useful separation of concerns.
A Chameleon prototype demonstrates the feasibility of the approach on a (NUMA) Butterfly and a (UMA) Sequent multiprocessor. Experiments with the prototype indicate that the Chameleon model and system perform well in practice.
Memory of AMR coded speech distorted by packet loss (2014)

Previous studies have shown that free recall of spoken word lists is impaired if the speech is presented in background noise, even if the signal-to-noise ratio is kept at a level allowing full word identification. The objective of this study was to examine recall rates for word lists presented in noise and word lists coded by an AMR (Adaptive Multi Rate) telephone codec distorted by packet loss. Twenty subjects performed a word recall test. Word lists consisting of ten words were played to the subjects. The subjects repeated each word immediately after it had been played, to ensure that the words were heard correctly. After the complete list had been played the subjects wrote down all words remembered. In this way, both word identification and recall rates were measured. Three distorted conditions were compared with an undistorted control condition using a within-subject design: speech spectrum weighted noise at 4 dB SNR, and AMR coded speech with two levels of packet loss, one mild and one severe. The results confirmed the disruptive effect of noise on free recall of words, while no significant impairment was found for the AMR distortions. The noise and the AMR coding with mild packet loss gave approximately the same impairment of word identification. The AMR coding with severe packet loss gave a larger impairment of word identification, even though the word recall rate was unaffected. This result suggests that packet loss in AMR coded speech causes distortions which disrupt recall of words less than noise at levels resulting in the same change of word identification rates. Since impairment of word identification rates did not correlate with impairment of word recall rates models for quality prediction of speech reproductions should not be based on identification rates alone.
Identification of Cys140 in helix 4 as an exofacial cysteine residue within the substrate-translocation channel of rat equilibrative nitrobenzylthioinosine (NBMPR)-insensitive nucleoside transporter rENT2 (2001)

The human and rat equilibrative nucleoside transporter proteins hENT1, rENT1, hENT2 and rENT2 belong to a family of integral membrane proteins with 11 potential transmembrane segments (TMs), and are distinguished functionally by differences in transport of nucleobases and sensitivity to inhibition by nitrobenzylthioinosine (NBMPR) and vasoactive drugs. In the present study, we have produced recombinant hENT1, rENT1, hENT2 and rENT2 in Xenopus oocytes and investigated uridine transport following exposure to the impermeant thiol-reactive reagent p-chloromercuriphenyl sulphonate (PCMBS). PCMBS caused reversible inhibition of uridine influx by rENT2, but had no effect on hENT1, hENT2 or rENT1. This difference correlated with the presence in rENT2 of a unique Cys residue (Cys140) in the outer half of TM4 that was absent from the other ENTs. Mutation of Cys140 to Ser produced a functional protein (rENT2/C140S) that was insensitive to inhibition by PCMBS, identifying Cys140 as the exofacial Cys residue in rENT2 responsible for PCMBS inhibition. Uridine protected wild-type rENT2 against PCMBS inhibition, suggesting that Cys140 in TM4 lies within or is closely adjacent to the substrate-translocation channel of the transporter. TM4has been shown previously to be within a structural domain (TMs 3Ő6) responsible for interactions with NBMPR, vasoactive drugs and nucleobases.
ACUTE RELEASE OF CATECHOLAMINES ON CIRCULATING BLOOD CELL ADRENOCEPTORS AND METABOLIC INDICES IN DOG (1988)

The effects of acute release of endogenous catecholamines on both platelet alpha 2 and leukocyte beta adrenoreceptors and metabolic indices (glucose and free fatty acids) were investigated in dogs by means of a model of neurogenic hypertension following acute sinoaortic denervation (ASAD). Despite the marked increase in catecholamine levels (+4.2-fold for noradrenaline and 16.7-fold for adrenaline, for example, at minute 45 following ASAD) and in glucose plasma levels, and the significant decrease in free fatty acid plasma levels, no change in platelet alpha 2 or leukocyte beta adrenoreceptor binding sites (number as well as affinity) was observed during the whole experiment. It is suggested that the number of platelet alpha 2- and leukocyte beta-adrenoreceptors is not submitted to short-term regulation, at least by endogenous catecholamines in dogs.
A software architecture for open service gateways (2001)

Two industrial trends are changing our day-to-day lives. One is the introduction of broadband service to the home, where it promises to deliver complex new services. The other is the increasing resourcefulness, connectedness, and intelligence of home appliances. A residential gateway is a networking device that creates a bridge between the broadband network and the in-home network, and between different networking technologies within the home. The article gives an overview of this emerging marketplace, and introduces the work ongoing at the Open Service Gateway initiative. OSG1 is defining a set of open-standard software application interfaces (APIs) for building open-service gateways, including residential gateways.
A study about FPGA-based digital filters (2002)

A set of operators suitable for digit-serial FIR filtering is presented. The canonical and inverted forms are studied. In each of these structures both the symmetrical and anti-symmetrical particular cases are also covered. All circuits have been implemented using an EPF10K50 Altera FPGA. The main results show that the canonical form presents less occupation and higher throughput. The 8-tap filter versions implemented can be applied in real-time processing with sample rate ranging up to 7 MHz using the bit-serial versions and up to 25 MHz with the bit-parallel ones.