gebhart/patrepeval huggingface dataset:
Fabrication of polyimide based microfluidic channels for biosensor devices (2015)

The ever-increasing complexity of the fabrication process of Point-of-care (POC) devices, due to high demand of functional versatility, compact size and ease-of-use, emphasizes the need of multifunctional materials that can be used to simplify this process. Polymers, currently in use for the fabrication of the often needed microfluidic channels, have limitations in terms of their physicochemical properties. Therefore, the use of a multipurpose biocompatible material with better resistance to the chemical, thermal and electrical environment, along with capability of forming closed channel microfluidics is inevitable. This paper demonstrates a novel technique of fabricating microfluidic devices using polyimide (PI) which fulfills the aforementioned properties criteria. A fabrication process to pattern microfluidic channels, using partially cured PI, has been developed by using a dry etching method. The etching parameters are optimized and compared to those used for fully cured PI. Moreover, the formation of closed microfluidic channel on wafer level by bonding two partially cured PI layers or a partially cured PI to glass with high bond strength has been demonstrated. The reproducibility in uniformity of PI is also compared to the most commonly used SU8 polymer, which is a near UV sensitive epoxy resin. The potential applications of PI processing are POC and biosensor devices integrated with microelectronics.
Coordinate downregulation of multiple MHC class I antigen processing genes in chemical‐induced murine tumor cell lines of distinct origin (2000)

In murine tumor cell lines, downregulation of MHC class I surface expression has been frequently detected, but the underlying molecular mechanisms of such deficiencies have not been defined. In this study, murine tumor cell lines of different histology derived from spontaneous or from chemical-induced tumors were analyzed for the expression of multiple components of the major histocompatibility complex (MHC) class I antigen-processing machinery (APM), including the peptide transporter TAP, the interferon (IFN)-gamma inducible proteasome subunits and several chaperones. The tumor cell lines analyzed demonstrated a heterogeneous expression pattern of various APM components. In comparison to control cells an impaired coordinated expression of at least three APM components was detected. In particular, extensive APM deficiencies were found in cell lines derived from chemical-induced tumors. A strong coordinated downregulation of expression and/or function of TAP, the low molecular weight proteins (LMP) subunits, the proteasome activator PA28 and/or tapasin was found in 5 of 10 tumor cells, which was associated with impaired MHC class I surface expression. In contrast, the expression of beta2-microglobulin (beta2-m), PA28beta, the constitutive proteasome subunits X, Y, Z and of the chaperones calnexin, calreticulin, ER60 and phospho disulfide isomerase (PDI) was unaltered or only weakly decreased. The deficient expression of APM components could be corrected by IFN-gamma treatment, which also reconstituted MHC class I surface expression. However, impaired expression of APM molecules appears not to be the only cause of abnormal MHC class I expression, since it could neither be corrected by the addition of exogeneous MHC class I binding peptides nor by incubation at low temperature. These results suggest that one major mechanism of murine tumor cells, in particular chemical-induced tumors, to evade the immune system is the combined dysregulation of various APM components and other factors, which still have to be identified.
Abstract 3770: PK/PD/Efficacy characterization of AZ285, a selective CK2 kinase inhibitor (2012)

Abstract Casein Kinase 2 (CK2) is an abundant, highly conserved protein serine/threonine kinase with numerous physiological targets and participates in the maintenance of cell viability with a role in cell growth and proliferation. While the expression level of CK2 in normal cells is tightly regulated, there is an increasing body of evidence demonstrating it's over expression in cancerous cells, thereby making inhibition a viable chemotherapeutic target. Here we will describe a mathematical tumor growth inhibition model describing the relationship between systemic exposure to a potent inhibitor of CK2 (AZ285) and efficacy in the HCT116 xenograft model. Furthermore, a PK/PD model describing the onset, intensity, and duration of the pAKT and cleaved caspase 3 response as function of concentration and time is described and linked to pre-clinical xenograft efficacy outcomes. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3770. doi:1538-7445.AM2012-3770
Site-Selective Functionalization of Methionine Residues via Photoredox Catalysis (2020)

Bioconjugation technologies have revolutionized the practice of biology and medicine by allowing access to novel biomolecular scaffolds. New methods for residue-selective bioconjugation are highly sought to expand the toolbox for a variety of bioconjugation applications. Herein we report a site-selective methionine bioconjugation protocol that uses photoexcited lumiflavin to generate open-shell intermediates. This reduction-potential-gated strategy enables access to residues unavailable with traditional nucleophilicity-based conjugation methods. To demonstrate the versatility and robustness of this new protocol, we have modified various proteins and further utilized this functional handle to append diverse biological payloads.
The interface-modulated structure of TaSi0.360Te2 (1994)

The incommensurate modulation in the structure of TaSi 0.360 Te 2 has been determined by single-crystal X-ray diffraction. The (3+1)-dimensional superspace group is Pnma(00γ)s00, γ=0.3602 (8), basic unit-cell dimensions a=6.329 (3), b=14.031 (3), c=3.8258 (7) A, V=339.72 A 3 , Z=4. Refinement on 1907 reflections with I≥2.5σ(1) converged to R=0.097, R=0.064 for 521 main reflections, R=0.089 for 831 first-order satellites and R=0.174 for 555 second-order satellites. The structure can be regarded as based upon the structure of the commensurate parent compound TaSi 1/3 Te 2 modulated by the incommensurate insertion of interfaces consisting of units of the hypothetical orthorhombic commensurate compound TaSi 1/2 Te 2
Data from Targeting Mitochondrial Structure Sensitizes Acute Myeloid Leukemia to Venetoclax Treatment (2023)

&lt;div&gt;Abstract&lt;p&gt;The BCL2 family plays important roles in acute myeloid leukemia (AML). Venetoclax, a selective BCL2 inhibitor, has received FDA approval for the treatment of AML. However, drug resistance ensues after prolonged treatment, highlighting the need for a greater understanding of the underlying mechanisms. Using a genome-wide CRISPR/Cas9 screen in human AML, we identified genes whose inactivation sensitizes AML blasts to venetoclax. Genes involved in mitochondrial organization and function were significantly depleted throughout our screen, including the mitochondrial chaperonin &lt;i&gt;CLPB&lt;/i&gt;. We demonstrated that CLPB is upregulated in human AML, it is further induced upon acquisition of venetoclax resistance, and its ablation sensitizes AML to venetoclax. Mechanistically, CLPB maintains the mitochondrial cristae structure via its interaction with the cristae-shaping protein OPA1, whereas its loss promotes apoptosis by inducing cristae remodeling and mitochondrial stress responses. Overall, our data suggest that targeting mitochondrial architecture may provide a promising approach to circumvent venetoclax resistance.&lt;/p&gt;Significance:&lt;p&gt;A genome-wide CRISPR/Cas9 screen reveals genes involved in mitochondrial biological processes participate in the acquisition of venetoclax resistance. Loss of the mitochondrial protein CLPB leads to structural and functional defects of mitochondria, hence sensitizing AML cells to apoptosis. Targeting CLPB synergizes with venetoclax and the venetoclax/azacitidine combination in AML in a p53-independent manner.&lt;/p&gt;&lt;p&gt;&lt;i&gt;See related commentary by Savona and Rathmell, p. 831&lt;/i&gt;.&lt;/p&gt;&lt;p&gt;&lt;i&gt;This article is highlighted in the In This Issue feature, p. 813&lt;/i&gt;&lt;/p&gt;&lt;/div&gt;
Anomaly detection based on time series data from industrial automatic sewing machines (2022)

Industrial automatic sewing machines are used for the production of technical textiles and safety critical work pieces such as parachutes or safety belts. Hence, the production does not tolerate sewing errors within the final product. Unfortunately, errors like skip stitches or illusive sewing may occur even on correctly adjusted production machines due to their complex kinematics. A recently developed sensor for such production systems is able to measure the lower thread rotation, a key parameter of the sewing process. This opens up the possibility to analyze the sewing quality on the basis of time series data whilst the work piece is still in production, thus being able to instantly detect anomalous sewing operations which leads to reduced cost for quality control and improves safety. In this research we analyze the suitability of existing Neural Network based Machine Learning algorithms to detect anomalies within the available process data. We give an overview regarding the Machine Learning pipeline, the tested Neural Network types and the experimental results. We show that several Neural Network architectures are able to detect anomalies within the sewing process.
A system for interactive modeling of physical curved surface objects (1978)

It is often important to obtain descriptions of existing objects for computer graphics data bases. A system to aid interactive modeling (in three dimensions) of a physical object is described. The system allows a user to fit a bi-cubic parametric spline surface to an object by superimposing stereoscopic views of the computer surface with stereoscopic television views of the object. A 3-D joystick is used to manipulate surface control points while the user views the computed surface as isoparametric contours. A raster scan display polarization stereoscope is used. The left eye and right eye surface views are computed using a unique display processor designed and constructed for the evaluation of raster scan graphics techniques. The display processor consists of multiple non-pipelined concurrently operating microprogrammed modules. The computation of the two reasonably complex images (&gt;500 vectors each) takes less than 33 msec allowing real time display at standard television rates.
Neural Stem Cells: A Functional Definition Based onProteomics (2008)

Neural stem cells can be isolated from the adult mammalian brain throughout the entire lifetime of an organism, including humans. Unfortunately, no unique molecular marker could be identified expressed by all types of neural stem and progenitor cells in every developmental stage. Genomic and proteomic screening approaches suggest a functional definition of adult stem cells by their molecular inventory. These include (i) the responsiveness to growth factors, (ii) the reuse of developmental signaling cascades in adult progenitors, (iii) the interaction with molecules of the extracellular matrix, (iv) the expression of genes regulating transcription and translation, (v) mechanisms for controlling cell number, and (vi) the protection against cellular stress, such as hypoxia, or DNA damage.
Sequestration of latent TGF-β binding protein 1 into CADASIL-related Notch3-ECD deposits (2014)

We propose LTBP-1 as a novel component of Notch3-ECD deposits and suggest its involvement in pathological processes triggered by Notch3-ECD aggregation.
Simulation based investigation of hidden delamination damage detection in CFRP composites (2014)

Guided wave (GW) based damage detection methods have shown promise in structural health monitoring (SHM) and hybrid SHM-nondestructive evaluation (NDE) techniques. Much previous GW work in the aerospace field has been primarily focused on metallic materials, with a growing focus on composite materials. The work presented in this paper demonstrates how realistic three-dimensional (3D) GW simulations can aid in the development of GW based damage characterization techniques for aerospace composites. 3D elastodynamic finite integration technique is implemented to model GW interaction with realistic delamination damage. A local wavenumber technique is applied to simulation data in order to investigate the detectability of hidden delamination damage to enable accurate characterization of damage extent.
A 92.8% Efficiency Adaptive-On/Off-Time Control 3-Level Buck Converter for Wide Conversion Ratio with Shared Charge Pump Intermediate Voltage Regulator (2018)

This paper presents an efficient 3-level buck converter with cascode power stage and the proposed shared charge pump intermediate voltage (V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">MID</sub> ) regulator. The proposed charge pump (CP) shares flying capacitor C <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">FLY</sub> and power switches in the 3-level buck converter to generate V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">MID</sub> =V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">IN</sub> /2 achieving both small size and low loss. Also, conversion ratio (CR) V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">OUT</sub> /V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">IN</sub> is enhanced by using proposed adaptive-on/off-time (AOOT) control scheme. The control scheme switches between adaptive-on-time (AOnT) and adaptive-off-time (AOffT) mode according to the target CR. The proposed 3-level buck converter is implemented in a standard 0.25μm CMOS process showing 92.8% maximum efficiency and wide CR.
A band-notched UWB antenna using uni-planar EBG structure (2013)

In this paper, a notch in a UWB antenna using uni-planar electromagnetic bandgap (EBG) structure is presented. A one dimensional EBG structure coupled with microstrip line provides a narrow bandgap which is used in obtaining a notch in the ultra wideband (UWB) antenna. The effect of the meander line and the inter-digital capacitor of the unit cell are studied. A band notched UWB antenna is designed and fabricated giving a notch at 5.2 GHz WLAN frequency.
The acute abdomen, peritonitis and intra‐abdominal abscesses (2019)

The management of both the acute abdomen (a surgical emergency) and acute abdominal pain is an area of surgery where excellent clinical assessment by history, examination and observations is required to achieve safe and timely care for these very ill patients. This chapter outlines the importance of having a clinical pathway to arrive at a differential diagnosis and directed and relevant investigations to confirm the diagnosis. It also considers the broad management alternatives available to seek a solution to the immediate problem and provide definitive surgical care. Peritonitis and intra-abdominal abscess are examined in detail. It provides clinical examples to underline the processes utilised.
Microwave characteristics of MBE grown resonant tunneling devices (2003)

Resonant tunnel devices grown by molecular-beam epitaxy (MBE) have been measured experimentally using network analysis techniques from 130 MHz to 20 GHz. A circuit model for the devices has been extracted for two different InGaAs well structures at a fixed bias point, which fits the measured data well and is useful for circuit design. Additionally, the device impedance has been measured as a function of bias at a fixed frequency point. Complicated capacitance characteristics were observed for the devices with large-indium-content wells.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Ru-Catalyzed Regiospecific Borylation of Methyl C-H Bonds (2006)

Alkylboronic derivatives are recently gaining interest as synthetic intermediates, due to the raising amount of newly discovered transformations involving these versatile organometallics. Direct catalytic C-H activation is a new synthetic approach which is of great interest and offers new ways of functionalization of organic substrates. This is the first report of the use of relatively inexpensive ruthenium catalysis for the borylation of simple alkanes. The reaction is highly selective for Me groups and requires 2-5 mol% of Ru species as catalyst. β-Amino- and -alkoxyboronic derivatives, unavailable by conventional organometallic methods, can be obtained from the corresponding N- and O-alkyl species using this elegant approach.
The asymptotic limits of interference in multicell networks with channel aware scheduling (2011)

Interference is emerging as a fundamental bottleneck in many important wireless communication scenarios, including dense cellular networks and cognitive networks with spectrum sharing by multiple service providers. Although multiple-antenna signal processing is known to offer useful degrees of freedom to cancel interference, extreme-value theoretic analysis recently showed that, even in the absence of multiple-antenna processing, the scaling law of the capacity in the number of users for a multi-cell network with and without inter-cell interference was asymptotically identical provided a simple signal to noise and interference ratio (SINR) maximizing scheduler is exploited. This suggests that scheduling can help reduce inter-cell interference substantially, thus possibly limiting the need for multiple-antenna processing. However, the convergence limits of interference after scheduling in a multi-cell setting are not yet identified. In this paper <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> we analyze such limits theoretically. We consider channel statistics under Rayleigh fading with equal path loss for all users or with unequal path loss. We uncover two surprisingly different behaviors for such systems. For the equal path loss case, we show that scheduling alone can cause the residual interference to converge to zero for large number of users. With unequal path loss however, the interference power is shown to converge in average to a nonzero constant. Simulations back our findings.
Revista de tesis de la Facultad de Medicina de Bogotá (1943)

Algo sobre glaucoma. Tesis de grado declarada meritoria. 1943. Por Vicente Jannini Díaz / La reserva alcalina como pronóstico pre-operatorio. Tesis de grado, declarada meritoria. Por Rafael Amaya Pineda / Cien observaciones sobre el síndrome reacción leprosa. Tesis de grado. 1943. Por Mario Sánchez Medina / Anestesia general por oleo-eterización rectal. Tesis de grado. 1943. Por Eduardo Baquero Monzón / Afecciones broncopulmonares por infecciones crónicas de los senos de la cara. Tesis de grado. 1943. Por Alvaro Mosquera Chaux / Las sales de calcio en el tratamiento de la ulcera gastro-duodenal. Tesis de grado. 1943. Por Víctor M. Pedroza V. / La hormona folicular en el cáncer ginecológico. Tesis de grado. 1943. Por Daniel Mariño Zuleta
Differences in susceptibilities of the lymphogranuloma venereum and trachoma biovars of Chlamydia trachomatis to neutralization by immune sera (1990)

Sera from seven patients from whom a C. trachomatis serovar L2 strain was isolated were tested in vitro for their ability to neutralize the infectivity of this organism. In one patient an inguinal lymph node was culture positive, whereas the remaining six patients had positive rectal biopsies. Sera from four of the patients, including the patient with the lymph node isolate, failed to neutralize serovar L2(434). In addition, the homologous strain recovered from the inguinal lymph node was available and was resistant to neutralization by the homologous sera. However, the same sera effectively neutralized a trachoma serovar, E(Bour). All four sera had inclusion immunofluorescent-antibody titers to C. trachomatis serovar L2 of 2,048 to 16,384 and microimmunofluorescent-antibody titers to the lymphogranuloma venereum biovar were equal or higher in all cases than to the 12 serovars of the trachoma biovar. The three remaining sera, while neutralizing the infectivity of the L2 strains tested, neutralized serovar E to a greater extent. These sera had the same inclusion immunofluorescent antibody titers as the sera that failed to neutralize serovar L2. To see whether this difference in the sensitivity of the biovars toward neutralization could be characterized, sera were obtained from mice immunized with different doses of both serovars L2 and E. Sera obtained from mice immunized with serovar E were able to effectively neutralize the homologous strain. In contrast, neutralization of the immunizing strain, L2(UCI-20), was not seen with sera obtained on days 7, 14, and 21 after immunization from animals receiving 8 x 10(5) and 8 x 10(4) inclusion-forming units of L2(UCI-20); however, these same sera neutralized serovar E. However, with a higher immunizing dose of L2 (10(7) IFUs), both E and L2 were neutralized with sera obtained 7 and 14 days after immunization. Therefore, the relative resistance to neutralization by serovar L2 compared with that of serovar E in the mouse model was inoculum dependent.
Improved glucose tolerance in acyl CoA:diacylglycerol acyltransferase 1-null mice is dependent on diet (2007)

These results suggest that although ablation of DGAT1 improves glucose tolerance by preventing obesity in mice fed on a high fat diet, it does not improve glucose tolerance in mice fed on a low fat diet.
Reliability-Redundancy Allocation for Multi-State Series-Parallel Systems (2008)

Current studies of the optimal design of multi-state series-parallel systems often focus on the problem of determining the optimal redundancy for each stage. However, this is only a partial optimization. There are two options to improve the system utility of a multi-state series-parallel system: 1) to provide redundancy at each stage, and 2) to improve the component state distribution, that is, make a component in states with respect to higher utilities with higher probabilities. This paper presents an optimization model for a multi-state series-parallel system to jointly determine the optimal component state distribution, and optimal redundancy for each stage. The relationship between component state distribution, and component cost is discussed based on an assumption on the treatment on the components. An example is used to illustrate the optimization model with its solution approach, and that the proposed reliability-redundancy allocation model is superior to the current redundancy allocation models.
Modus operandi for a picture archiving and communication system. (1984)

The authors describe their 18 month experience operating an all digital nuclear medicine department, which led to the development of a system that allows multiple users to access patient reports and images through terminals located in various parts of the hospital. All user interactions are mediated through protocols that automatically acquire, process, display, and archive data. This approach offers distinct advantages over film and paper methods and is applicable in theory to any digital image format.