gebhart/patrepeval huggingface dataset:
Supplementary Data from Menin-mediated Repression of Glycolysis in Combination with Autophagy Protects Colon Cancer Against Small-molecule EGFR Inhibitors (2023)

&lt;p&gt;Supplementary Figures 1-5&lt;/p&gt;
Re‐evaluation of cord blood arterial and venous reference ranges for pH, pO2, pCO2, according to spontaneous or cesarean delivery (2010)

Umbilical cord blood gas analysis (pO(2) and pCO(2)) is now recommended in all high-risk baby deliveries and in some centers it is performed routinely following all deliveries. The aim of this study was to re-evaluate cord blood arterial and venous reference ranges for pH, pO(2), pCO(2) in newborns, delivered by spontaneous vaginal delivery (SVD) and by cesarean section (CS) performed in Faculty Hospital Motol. Two groups of subjects were selected for the study. Group I consisted of 303 newborns with SVD. Group II consisted of 189 newborns delivered by cesarean section. Cord blood samples were analyzed for standard blood gas and pH, using the analytical device Rapid Lab 845 and Rapid Lab 865. We obtained reference values expressed as range (lower and upper reference value expressed as 2.5 and 97.5 percentiles) for cord blood in newborns with SVD: arterial cord blood: pH=7.01-7.39; pCO(2)=4.12-11.45 kPa; pO(2)=1.49-5.06 kPa; venous cord blood: pH=7.06-7.44; pCO(2)=3.33-9.85 kPa; pO(2)=1.80-6.29 kPa. We also obtained reference values for cord blood in newborns delivered by CS: arterial cord blood: pH=7.05-7.39; pCO(2)=5.01-10.60 kPa; pO(2)=1.17-5.94 kPa; venous cord blood: pH=7.10-7.42; pCO(2)=3.88-9.36 kPa; pO(2)=1.98-7.23 kPa. Re-evaluated reference ranges play essential role in monitoring conditions of newborns with spontaneous and caesarean delivery.
Role of Gene Order in Developmental Control of Human γ- and β-Globin Gene Expression (1993)

To determine the effect of gene order on globin gene developmental regulation, we produced transgenic mice containing two tandemly arranged gamma- or beta-globin or gamma beta- and beta gamma-globin genes linked to a 2.5-kb cassette containing sequences of the locus control region (LCR). Analysis of constructs containing two identical gamma or beta genes assessed the effect of gene order on globin gene expression, while analysis of constructs containing tandemly arranged gamma and beta genes assessed any additional effects of the trans-acting environment. When two gamma genes were tandemly linked to the LCR, expression from the proximal gamma gene was three- to fourfold higher than expression from the distal gamma gene, and the ratio of proximal to distal gene expression remained unchanged throughout development. Similarly, when two beta genes were tandemly linked to the LCR, the proximal beta gene was predominantly expressed throughout development. These results indicate that proximity to LCR increases gene expression, perhaps by influencing the frequency of interaction between the LCR and globin gene promoters. An arrangement where the gamma gene was proximal and the beta gene distal to the LCR resulted in predominant gamma-gene expression in the embryo. When the order was reversed and the gamma gene was placed distally to the LCR, gamma-gene expression in the embryo was still up to threefold higher than expression of the LCR-proximal beta gene. These findings suggest that the embryonic trans-acting environment interacts preferentially with the gamma genes irrespective of their order or proximity to the LCR. We conclude that promoter competition rather than gene order plays the major role in globin gene switching.
Improving author coreference by resource-bounded information gathering from the web (2007)

Accurate entity resolution is sometimes impossi-ble simply due to insufficient information. For ex-ample, in research paper author name resolution, even clever use of venue, title and co-authorship relations are often not enough to make a confi-dent coreference decision. This paper presents sev-eral methods for increasing accuracy by gather-ing and integrating additional evidence from the web. We formulate the coreference problem as one of graph partitioning with discriminatively-trained edge weights, and then incorporate web informa-tion either as additional features or as additional nodes in the graph. Since the web is too large to incorporate all its data, we need an efficient pro-cedure for selecting a subset of web queries and data. We formally describe the problem of re-source bounded information gathering in each of these contexts, and show significant accuracy im-provement with low cost. 1
NCA flip-chip bonding with thermoplastic elastomer adhesives - Fundamental failure mechanisms and opportunities of polyurethane bonded NCA-interconnects (2011)

NCA flip-chip bonding with thermoplastic elastomer adhesives is a new approach to connect surfaces - mostly with at least one flexible component - electrically and mechanically in one step. Although NCA bonding in general is a well-known process, so far only high-modulus thermosetting epoxy or acrylic adhesives are used. The application of thermoplastic elastomer adhesives identifies new opportunities for bonding flexible substrates but also implies challenges. The process is predestined for cost-efficient and reliable production due to the high availability of polyurethanes as cheap NCA adhesive and its excellent adhesion character. To evaluate fundamental failure mechanisms and long-term stability of the electrical interconnection this work investigates a classical flip-chip assembly with polyurethane film (PU) as NCA adhesive. DMA, TMA and Micro DAC analyses of the adhesive material characterize the fundamental thermo-mechanical behavior. Additionally, an approximation of the master curve allows an estimation of relaxation times. Temperature cycling and thermal load tests confirm that mechanical motions and stress relaxation do not affect reliability of the contacts at temperatures between -40 °C/85 °C.
Influence of hyperglycemia on insulin's in vivo effects in type II diabetes. (1984)

The present study was designed to quantitate the interaction between the decrease in target tissue insulin action seen in subjects with Type II diabetes and the mass action effect of glucose exerted via the prevailing hyperglycemic state. To this end, euglycemic glucose clamp studies were performed in 26 control subjects using insulin infusion rates of 15, 40, 120, 240, and 1,200 mU/M2 per min and in 10 Type II diabetic subjects using insulin infusion rates of 120 and 1,200 mU/M2 per min. The results of these euglycemic studies indicated that insulin-stimulated peripheral glucose disposal was decreased in the Type II diabetics due to a combined receptor (rightward shift in the dose-response curve) and postreceptor defect in insulin action (decreased maximal response), whereas the decrease in insulin-mediated suppression of hepatic glucose output (HGO) was consistent with a defect in insulin binding (rightward shift in dose-response curve). Hyperglycemic glucose clamp studies were also performed in the Type II diabetics at their respective fasting serum glucose levels (mean [+/- SE] 280 +/- 17 mg/dl) employing insulin infusion rates of 15, 40, 120, and 1,200 mU/M2 per min. In the presence of their basal level of hyperglycemia, the noninsulin-dependent diabetes mellitus (NIDDM) subjects exhibited rates of overall glucose disposal that were similar to those observed in control subjects studied at euglycemia at similar steady state insulin concentrations. This suggests that in Type II diabetics, the mass action effect of glucose partially compensates for the marked decrease in insulin-stimulated glucose uptake observed under euglycemic conditions. However, even in the presence of hyperglycemia, insulin levels below 100 microU/ml had little effect and maximally effective insulin levels increased peripheral glucose disposal only 2.8-fold (142 +/- 7-413 +/- 47 mg/M2 per min) above basal in the Type II diabetics, compared with a sixfold increase (75 +/- 4-419 +/- 34 mg/M2 per min) in the control subjects studied at euglycemia. Thus, the severe insulin resistance that is a characteristic feature of NIDDM remains apparent. Basal HGO was elevated in the NIDDM subjects (157 +/- 6 vs. 76 +/- 4 mg/M2 per min for controls) and a high degree of correlation was found between the basal rate of HGO and the fasting glucose level (r = 0.80, P less than 0.01). The presence of hyperglycemia augmented insulin-mediated suppression of HGO, but did not restore it to normal. We concluded that: (a) in the presence of basal hyperglycemia, physiologic insulin levels exerts a diminished effect to suppress HGO and stimulate peripheral glucose disposal in NIDDM; (b) basal HGO is elevated in untreated Type II diabetics, and this may serve to maintain the level of hyperglycemia required to compensate for the decrease in peripheral insulin action; and (c) fasting hyperglycemia exerts a suppressive effect on HGO but does not completely compensate for the decrease in hepatic insulin action in Type II diabetics.
A Study of Clinical Coding Accuracy in Surgery (2014)

The coded data are a key engine for knowledge-driven health care provision. They are used, increasingly at individual surgeon level, to benchmark performance. Surgical clinical coding is prone to subjectivity, variability, and error (SVE). Having a specialty-by-specialty understanding of the nature and clinical significance of informatics variability and adopting strategies to reduce it, are necessary to allow accurate assumptions and informed decisions to be made concerning the scope and clinical applicability of administrative data in surgical outcomes improvement.
Thiophen‐basierte konjugierte acetylenische Polymere mit dualen aktiven Zentren für effiziente Cokatalysator‐freie photoelektrochemische Wasserreduktion im alkalischen Medium (2021)

Abstract Konjugierte Polymere sind attraktive Materialien für die photoelektrochemische Wasserstoffentwicklungsreaktion (PEC‐HER) unter neutralen oder sauren Bedingungen. Jedoch zeigen sie im alkalischen Medium immer noch eine geringe PEC‐HER‐Leistung aufgrund des Fehlens von Wasserdissoziations‐Zentren. Hier zeigen wir, dass durch Anpassung des konjugierten acetylenischen Polymers (CAPs) von Poly(diethinylthieno[3,2‐b]thiophen) ( pDET ) zu Poly(2,6‐diethinylbenzo[1,2‐b:4,5‐b′]dithiophen ( pBDT ) und Poly(diethinyldithieno[3,2‐b:2′,3′‐d]thiophen) ( pDTT ) hocheffiziente aktive Wasserdissoziations‐Zentren in CAPs eingeführt werden können. Infolgedessen zeigen auf Cu‐Substrat gewachsene pDTT und pBDT Benchmark‐Photostromdichten von 170 μA cm −2 und 120 μA cm −2 (bei 0,3 V vs. RHE; pH 13), die 4,2‐ bzw. 3‐mal höher sind als die von pDET . DFT‐Rechnungen und elektrochemische Operando‐Resonanz‐Raman‐Spektroskopie zeigen, dass die elektronenangereicherten C β der äußeren Thiophenringe von pDTT die aktiven Zentren für die Wasserdissoziation sind, während die ‐C≡C‐Bindungen als aktive Zentren für die Wasserstoffentwicklung fungieren.
Realizing Multioperations for Step Cached MP-SOCs (2006)

Recent advances in shared memory multiprocessor system-on-chip (MP-SOC) architectures include using special step caches to efficiently implement concurrent read concurrent write memory access. Unfortunately the existing step cache techniques do not support multioperations that can be used to speed up execution of a number of parallel algorithms by a logarithmic factor. This paper proposed an architectural technique for implementing multioperations on step cached MP-SOCs even if the associativity of caches is limited. The technique is based on simple active memory units, faster memory modules, and small processor-level memory blocks called scratchpads. The performance and area requirements of the proposed technique were evaluated on the parametrical MP-SOC framework. According to the evaluation the technique implements multioperations efficiently and provides a speed-up of 4.8 - 7.2 with respect baseline step cached systems and a speed-up of 3.7- 5.0 with respect to existing non-step cached systems with only a minor silicon are overhead
Various attractions of microalgae: systematics, evolution, genome to morphology, algal biotechnology (2017)

1/10 mmにも満たない微細な藻類の育種が注目されている．大気に含まれる酸素のほとんども，白亜の海岸も，シェールガスさえもが，地質時代に地球上で大繁殖した微細藻類に由来する．本レポートは，日本植物学会第80回大会（2016年9月16日～19日 沖縄）のなかのシンポジウム3aSB01-06「微細藻類の多様な魅力：分類，進化，ゲノムから形態，藻類バイオまで」からの報告である．微細藻類の多様な魅力を紹介するために，老若男女―黒岩先生から野村真未さんまで，さまざまなキャリアとセンスの研究者に思う存分，微細藻類の多様な魅力を語ってもらった．
A photoconductivity study of electron transfer between CdS and TiO2 powders in vacuum and in an O2 atmosphere (1988)

Photoconductance measurements have been carried out in the visible and/or ultraviolet spectral region, under vacuum or under various O2 pressures, at room temperature for the powders CdS, TiO2, mixtures of CdS with a small amount of TiO2(or SiO2 for comparison) and a CdS–TiO2 double pellet. Under vacuum, regardless of the spectral range, the effects of TiO2 on the CdS photoconductance or conductivity after illumination are interpreted by electron transfer from TiO2 to CdS. In the presence of O2, this transfer is limited by oxygen species adsorbed on TiO2, which deplete this material of its free electrons (pressure dependence) and which can also capture free electrons of CdS to an extent which depends on the number and areas of the interfaces between particles of the two semiconductors.
Novel optical hybrid line configuration for quasi-lossless transmission by distributed Raman amplification (2001)

We propose a novel lossless transmission line configuration which exhibits significantly small signal power variation along the line by Raman amplification. A hybrid line consisting of two fibers with different Raman gain properties is theoretically investigated, and it is shown that signal power deviation can be suppressed to only 1.2 dB in a 50-km span. Validity of the proposed hybrid line is confirmed by experiments.
Validate Crack Assessment Models With In-Service and Hydrotest Failures (2018)

Crack or crack-like anomaly is one of the major threats to the safety and structural integrity of oil and gas pipelines. Various assessment models have been developed and used within pipeline industry to predict the burst capacity for pipelines containing longitudinally-oriented surface cracks. These models have different level of conservatism, accuracy, and precision which significantly impacts pipeline operators’ integrity mitigation decisions such as pressure restriction, excavation, and repair, and also lead to different level of safety. This paper compares the accuracy and precision of the most commonly used crack assessment models, i.e. Modified Ln-Sec, CorLAS, API 579 Level 2 and the recent-published PRCI MAT-8 model using in-service and hydrostatic testing failure data. A total number of 12 in-service and 63 hydrostatic test pipe ruptures due to stress corrosion cracking (SCC) with actual burst pressure, material property, and detailed crack size measurements are collected, and used to derive the probabilistic characteristics of the model errors associated with each model. Compared to the burst tests conducted in the laboratory and investigated in other previous studies, the results obtained from in-service and hydrostatic test ruptures are more representative of the real boundary conditions in pipeline operation. All the assumptions and empirical correlations associated with each model are discussed in details. The analysis result suggests that CorLAS is the most accurate model with the least uncertainty (or highest precision). Mitigation activities can be optimized without compromising safety by using the most accurate and precise model.
Antenna Integration in Packaging Technology operating from 60 GHz up to 300 GHz (HDI‐based AiP) (2020)

With the rise of consumer applications at millimeter-wave (mmWave) frequencies during the past ten years, we have witnessed strong research activity dealing with the integration of mmWave antennas in the package of electronic sub-systems. This chapter provides an overview of the work performed by STMicroelectronics and the University of Nice (Polytech'Lab) to design innovative antenna-in-package solutions integrated on "organic" microelectronic packaging technology and assess their achievable performance. The performance is assessed in below 100-GHz band, 120–140-GHz band, and beyond 200-GHz band. In the below 100 GHz and 120–140-GHz bands, both excellent antenna performance and agreement with simulations have been achieved. The accuracy issue faced by the first organic substrate-based AiP beyond 200 GHz should be solved by more aggressive design rules.
Advances and emerging techniques for energy recovery during absorptive CO2 capture: A review of process and non-process integration-based strategies (2021)

Absorptive CO2 Capture (ACC) is widely embraced as a mature technology to mitigate CO2 emission, but it is energy-intensive and expensive to implement on a commercial scale. It is envisaged that energy recovery could be achieved during ACC by synthesizing and integrating a complex network of flexible heat exchangers to transfer as much energy as possible from a set of hot flows to cold flows. This review provides information on the progress made in the development of process and non-process integration-based techniques alongside their benefits for effective energy recovery during ACC. An exposition on the integration of flexible Heat Exchanger Networks (HENs), its synthesis methodologies, and developments for improving energy recovery during ACC is presented. Furthermore, this review highlights the current state of knowledge creation in process integration and ACC, as well as its underpinning principles, challenges, and opportunities to provide a summary and important discussion on current practices in process integration-based strategies for energy recovery. Current opinions on the integration of flexible HENs for energy recovery during ACC are highlighted. The review also presents a proposed roadmap for large-scale energy recovery during ACC, and suggestions on the improvement opportunities for future research and development were provided. Finally, this review revealed that the integration of flexible HENs is a promising technique for energy recovery during ACC. This study will be beneficial to researchers exploring cost-effective methods for designing sustainable energy systems for effective energy recovery.
Retrieving the signal from ultra-small-angle x-ray scattering with polychromatic radiation in speckle-tracking and beam-tracking phase-contrast imaging (2017)

We present an experimental comparison between two x-ray phase contrast imaging techniques currently under development, speckle-tracking and beam-tracking. The comparison is centred on the absorption and ultra-small-angle scattering signals retrieved with polychromatic radiation from homogeneous and inhomogeneous samples of different thicknesses. Our analysis shows that the ultra-small-angle scattering signal retrieved with speckle-tracking does not increase linearly with the thickness for the inhomogeneous sample, and is different from zero for the homogeneous sample. The results obtained from beam-tracking, instead, are in good agreement with expectation.
Density functional theory molecular dynamics simulations and experimental measurements of a-HfO<inf>2</inf>/a-SiO/SiGe(001) and a-HfO<inf>2</inf>/a-SiO<inf>2</inf>/SiGe(001) interfaces (2017)

To determine the optimal interface between a-HfO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> igh-K oxide and Si <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.5</inf> Ge <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.5</inf> (001), density functional theory molecular dynamics (DFTMD) simulations of several amorphous stoichiometric and sub-stoichiometric SiOxNy interlayers were performed. The stack with oxygen deficient a-SiO interlayer demonstrated superior electric properties because it avoided all dangling bond formation. Experimental studies confirmed that a nearly pure SiOx interface between a-HfO2 and SiGe(001) could be formed which correlated with a low interface state density.
Algebraic secret sharing using privacy homomorphisms for IoT-basedhealthcare systems (2019)

Healthcare industry is one of the promising fields adopting the Internet of Things (IoT) solutions. In this paper, we study secret sharing mechanisms towards resolving privacy and security issues in IoT-based healthcare applications. In particular, we show how multiple sources are possible to share their data amongst a group of participants without revealing their own data to one another as well as the dealer. Only an authorised subset of participants is able to reconstruct the data. A collusion of fewer participants has no better chance of guessing the private data than a non-participant who has no shares at all. To realise this system, we introduce a novel research upon secret sharing in the encrypted domain. In modern healthcare industry, a patient's health Article often contains data acquired from various sensor nodes. In order to protect information privacy, the data from sensor nodes is encrypted at once and shared among a number of cloud servers of medical institutions via a gateway device. The complete health Article will be retrieved for diagnosis only if the number of presented shares meets the access policy. The retrieval procedure does not involve decryption and therefore the scheme is favourable in some time-sensitive circumstances such as a surgical emergency. We analyse the pros and cons of several possible solutions and develop practical secret sharing schemes for IoT- based healthcare systems.
Visualizing the Onset and Evolution of an Autoantibody Response in Systemic Autoimmunity (2005)

The onset of systemic autoimmunity is variable, making it difficult to identify early events. In this study, we show in rheumatoid factor (RF) Ig-transgenic autoimmune-prone mice that the appearance of RF B cells in blood signifies the onset of RF B cell activation in spleen, providing a novel window into the initiation of an autoantibody response. This allowed us to study the early and late phases of spontaneous induction of the B cell autoimmune response. Using this approach we showed that extensive Ab-forming cell generation in spleen, accompanied by somatic hypermutation, occurred despite the lack of an early germinal center response. The onset of the RF response correlated with the levels of IgG2a-containing immune complexes but not total IgG2a. By identifying the time of onset in individual mice, we were able to track progression of disease. We found remissions of RF Ab-forming cell production in some mice, suggesting that at the clonal level, chronic autoantibody responses are dynamic and episodic, much like acute pathogen responses. Surprisingly, there was little accumulation of long-lived plasma cells in bone marrow of mice with long-standing RF responses in spleen. These studies are among the first to define the early events of a spontaneous B cell autoimmune response.