gebhart/patrepeval huggingface dataset:
Estimation of Quasi-Stiffness of the Human Knee in the Stance Phase of Walking (2013)

Biomechanical data characterizing the quasi-stiffness of lower-limb joints during human locomotion is limited. Understanding joint stiffness is critical for evaluating gait function and designing devices such as prostheses and orthoses intended to emulate biological properties of human legs. The knee joint moment-angle relationship is approximately linear in the flexion and extension stages of stance, exhibiting nearly constant stiffnesses, known as the quasi-stiffnesses of each stage. Using a generalized inverse dynamics analysis approach, we identify the key independent variables needed to predict knee quasi-stiffness during walking, including gait speed, knee excursion, and subject height and weight. Then, based on the identified key variables, we used experimental walking data for 136 conditions (speeds of 0.75-2.63 m/s) across 14 subjects to obtain best fit linear regressions for a set of general models, which were further simplified for the optimal gait speed. We found R(2) > 86% for the most general models of knee quasi-stiffnesses for the flexion and extension stages of stance. With only subject height and weight, we could predict knee quasi-stiffness for preferred walking speed with average error of 9% with only one outlier. These results provide a useful framework and foundation for selecting subject-specific stiffness for prosthetic and exoskeletal devices designed to emulate biological knee function during walking.
Evaluation of a newly developed assay designed to assess the interaction between α4β7 and MAdCAM (2016)

Abstract HIV infection is characterized by high-level replication in gut-associated lymphoid tissues (GALT). This occurs in part because α4β7 ;+/CD4+ T cells are a preferred target of HIV infection. α4β7 functions as a gut homing receptor. Homing is mediated through a specific interaction with MAdCAM that is expressed on the surface of the high-endothelial venules that line the gut. In addition, α4β7 binds to the V2 domain of HIV gp120. In an SIV model of HIV mucosal transmission, an antibody specific for α4β7 ;+was found to prevent infection, but the underlying mechanism for this protection is not fully understood. We have proposed that signaling through α4β7 ;+ facilitates HIV transmission, and that the protection from infection that we observed may reflect the capacity of the anti-α4β7 mAb we employed to interfere with this signaling. In order to investigate the role of α4β7 + signaling in mucosal transmission, we have employed a newly developed adhesion assay (Peachman and Rao) that measures the interaction between either the V2 domain of HIV gp120 or MAdCAM with cells expressing α4β7. We have used this assay to evaluate small molecules and antibody antagonists of these interactions. We have found that small molecule antagonists that bind to the active site in α4β7 abrogate binding of cells to both MAdCAM and the V2 domain of HIV gp120. In addition, we determined that retinoic acid increases the adhesion of MAdCAM and V2 to α4β7 expressing cells. This assay should aid in the development of novel strategies designed to interfere with the trafficking of α4β7 ;+cells to GALT and to mucosal transmission of HIV.
Расчет параметрического усиления в фотонно-кристаллическом волокне (2012)

Signal wave parametric gain was calculated in photonic crystal optical fiber. Photonic crystal fiber structure was optimized for broadband parametric gain. It is shown, that gain bandwidth for photonic-crystal fiber optical parametric amplifier could be more than 400 nm. Spectral changings in parametric gain due to modulation of photonic crystal waveguide cross-section was studied
COMPARISON OF THE DIFFERENTIAL TIME COURSES OF THE VASODILATATION BY VARIOUS CALCIUM ANTAGONIST IN SMALL HUMAN SUBCUTANEOUS ARTERIES (2000)

Dept. Pharmacotherapy, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
Monte Carlo evaluation of real-time Feynman path integrals for quantal many-body dynamics: distributed approximating functions and Gaussian sampling (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMonte Carlo evaluation of real-time Feynman path integrals for quantal many-body dynamics: distributed approximating functions and Gaussian samplingDonald J. Kouri, Wei Zhu, Xin Ma, B. Montgomery Pettitt, and David K. HoffmanCite this: J. Phys. Chem. 1992, 96, 24, 9622–9630Publication Date (Print):November 1, 1992Publication History Published online1 May 2002Published inissue 1 November 1992https://pubs.acs.org/doi/10.1021/j100203a013https://doi.org/10.1021/j100203a013research-articleACS PublicationsRequest reuse permissionsArticle Views156Altmetric-Citations64LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Heme Oxygenase-1 Protein Localizes to the Nucleus and Activates Transcription Factors Important in Oxidative Stress (2007)

Heme oxygenase-1 (HO-1), the rate-limiting enzyme in heme degradation, is an integral membrane protein of the smooth endoplasmic reticulum. However, we detected an HO-1 immunoreactive signal in the nucleus of cultured cells after exposure to hypoxia and heme or heme/hemopexin. Under these conditions, a faster migrating HO-1 immunoreactive band was enriched in nuclear extracts, suggesting that HO-1 was cleaved to allow nuclear entry. This was confirmed by the absence of immunoreactive signal with an antibody against the C terminus and the lack of a C-terminal sequence by gas chromatographymass spectrometry. Incubation with leptomycin B prior to hypoxia abolished nuclear HO-1 and the faster migrating band on Western analysis, suggesting that this process was facilitated by CRM1. Furthermore, preincubation with a cysteine protease inhibitor prevented nuclear entry of green fluorescent protein-labeled HO-1, demonstrating that protease-mediated C-terminal cleavage was also necessary for nuclear transport of HO-1. Nuclear localization was also associated with reduction of HO activity. HO-1 protein, whether it was enzymatically active or not, mediated activation of oxidant-responsive transcription factors, including activator protein-1. Nevertheless, nuclear HO-1 protected cells against hydrogen peroxide-mediated injury equally as well as cytoplasmic HO-1. We speculate that nuclear localization of HO-1 protein may serve to up-regulate genes that promote cytoprotection against oxidative stress.
Ovarian Fibroma with Leydig Cell Hyperplasia of the Adjacent Stroma (1986)

A virilizing left ovarian tumor removed from a 58-year-old woman was studied by light and electron microscopy. Histologically, the tumor was an ovarian fibroma around which Leydig cells, but no Sertoli cells, proliferated at a distance from the hilus. Although the fibroma itself did not contain Leydig cells, several Leydig cells were observed intermingled with ovarian stromal cells in the cortical tissue compressed by the fibroma. Ultrastructurally, in addition to mature Leydig cells with typical steroid-producing--cell features, immature cells with less-developed smooth endoplasmic reticulum and elementary tubular inclusions were identified. These light and electron microscopic findings suggest that the Leydig cells may have differentiated from ovarian stromal cells surrounding the fibroma. If so, this case should be distinguished from neoplastic disorders such as hilar cell tumors or stromal-Leydig cell tumors and be classified in the category of ovarian tumors with functioning stroma containing Leydig cells.
Coordinated gastric and sphincter motility evoked by intravenous CCK-8 as monitored by ultrasonomicrometry in rats (2004)

Gastric and sphincter motility evoked by intravenous injection of CCK-8 were investigated in urethane-anesthetized rats. Digital ultrasonomicrometry was used to monitor pyloric (PYL), antral (ANT), corpus (COR), and lower esophageal sphincter (LES) movements while simultaneously measuring intragastric pressure (IGP) and, in some experiments, subdiaphragmatic intraesophageal pressure (sIEP). Intracrystal distances (ICD) were measured continuously between pairs of piezoelectric crystals affixed to the serosa of PYL, ANT, COR (circular and longitudinal), and LES. Consecutive intravenous injections of CCK-8 (0.3, 1, and 3 microg/kg) at 30-min intervals caused dose-dependent simultaneous tonic contractions of PYL and ANT, LES opening, and drops in IGP with peak changes at 3 microg/kg of -17.9 +/- 2.1, -7.7 +/- 2.5, 6.5 +/- 1.4, and -29.2 +/- 3.8%, respectively, whereas intravenous saline had no effect. Rhythmic contractile activity was inhibited by CCK-8. COR responses were not significantly different from vehicle controls for most metrics, and the direction of response for circular COR varied between preparations, although not for repeated trials in a single preparation. During the LES response to CCK-8, sIEP rose in parallel with drops in IGP, indicating formation of a common cavity. Recovery of LES ICD after intravenous CCK occurred more rapidly than recovery of PYL ICD, suggesting the importance of preventing simultaneous patency of gastroesophageal and gastroduodenal passages. The CCK(A) receptor antagonist devazepide (500 microg/kg intravenous) inhibited motion responses evoked by intravenous CCK-8. These data revealed CCK-8-induced gastric and sphincter activity consistent with retropulsion of gastric content.
Associations between Emotional Distress, Sleep Changes, Decreased Tooth Brushing Frequency, Self-Reported Oral Ulcers and SARS-Cov-2 Infection during the First Wave of the COVID-19 Pandemic: A Global Survey (2022)

This study assessed the association between emotional distress, sleep changes, decreased frequency of tooth brushing, and self-reported oral ulcers, and the association between COVID-19 status and decreased frequency of tooth brushing. Using a cross-sectional online survey, data were collected from adults in 152 countries between July and December 2020. Binary logistic regression analyses were conducted to determine the associations between dependent (decreased frequency of tooth brushing, oral ulcers, change in sleep pattern) and independent (tested positive for COVID-19, depression, anxiety, frustration/boredom, loneliness, anger, and grief/feeling of loss) variables after adjusting for confounders (age, sex, level of education, employment status). Of the 14,970 participants data analyzed, 1856 (12.4%) tested positive for COVID-19. Respondents who reported feeling depressed (AoR: 1.375), lonely (AoR: 1.185), angry (AoR: 1.299), and experienced sleep changes (AoR:1.466) had significantly higher odds of decreased tooth brushing frequency. Respondents who felt anxious (AoR: 1.255), angry (AoR: 1.510), grief/sense of loss (AoR: 1.236), and sleep changes (AoR: 1.262) had significantly higher odds of oral ulcers. Respondents who tested positive for COVID-19 had significantly higher odds of decreased tooth brushing frequency (AoR: 1.237) and oral ulcers (AoR: 2.780). These findings highlight that the relationship between emotional distress and oral health may intensify during a pandemic.
Manufacturing and characterization of epoxy resin with Fe3O4 and SiO2 particles (2020)

Thermosetting polymers are very popular in the automotive and aeronautic industry, in particular epoxy resin is widely used as matrix thermoset in carbon and glass fibre reinforced composites. The properties of these epoxy-based polymers can be improved with the addition of particulate or small fibre materials in order to construct a lightweight material with enhanced mechanical and structural response. This work aimed to manufacture and characterize epoxy resin reinforced composites with iron (II, III) oxide (magnetite, Fe3O4) in amounts of 0.25, 0.5 and 1 wt%, and 2 and 4 wt% of fumed silicon dioxide (silica, SiO2). Mechanical properties were investigated by three-point bending flexural test, fracture toughness, flexural stress relaxation. In addition, apparent porosity, apparent density and Differential Scanning Calorimetry tests were performed. The results showed that the addition of Fe3O4 does not contribute significantly to the improvement of mechanical properties. However, fumed SiO2 promotes a considerable improvement in the mechanical properties. Keywords: Composite, epoxy resin, Fe3O4, SiO2, mechanical properties
Possibility of lasers based on the innershell transitions of Ne-like and Ni-like ions (1999)

Our earlier papers showed that laser gain is possible on the innershell 2s-2p transitions of Ne-like ions. This result was confirmed by more comprehensive calculations. In more recent works it was shown that laser gain is also possible on transitions between highly excited states. We summarize these results and present atomic-kinetic calculations for gain values along the Ne-like sequence for argon, iron, krypton, silver and xenon. For these ions the optimum plasma conditions are found for all possible laser transitions. We have also found some unknown laser transition in Ni-like tantalum and the optimum plasma parameters for laser action on these transitions.
High Power Operation Of Controlled Porosity Reservoir Cathodes (2017)

Summary form only given. Calabazas Creek Research, Inc. (CCR) introduced controlled porosity reservoir (CPR) cathodes in 2005 and provided experimental results and design information in 2010. Despite the encouraging experimental results, implementation into actual RF sources has been slow to occur. In 2013, CCR built an X-Band multiple beam klystron (MBK) using 16 CPR cathodes operating at 31 A/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . Unfortunately, the klystron never operated at high power due to an internal grid failure.
Quantitative Characterization of Optical Coupling in Nanoporous ZnO–WO3 and ZnO–PEDOT Composite Electrodeposited Gratings Using Electrodiffraction Measurements (2018)

To quantitatively characterize the optical coupling between ZnO (a high refractive index but nonabsorptive material) and an electrochromic material (either tungsten oxide (WO3) or poly(3,4-ethylenedioxythiophene) (PEDOT)), electrodiffractive and electrochromic properties were investigated from a novel two-component composite nanostructured electrodeposited grating that incorporated both ZnO and either WO3 or PEDOT. The sequential electrodeposition of these two materials through a photopatterned photoresist layer onto a fluorine-doped tin oxide (FTO)-coated glass substrate created a grating structure that exhibited optical diffraction that could be modulated electrochemically. SEM images of the electrochromic gratings revealed that the ZnO electrodeposition created a high surface area nanostructured thin film. The nanostructured ZnO is nonabsorbing, but its high refractive index and large surface area redirect light into the electrochromic grating and create a 4-fold enhancement in the grating’s electrodiffractive response.
Amiodaron-induzierte Pneumonitis bei dilatativer Kardiomyopathie (2002)

This report deals with two cases of amiodarone induced pulmonary toxicity in dilated cardiomyopathy leading to respiratory insufficiency. Pulmonary toxicity is a rare, but potentially lethal side effect of amiodarone. Reversibility of pulmonary changes in case of an early drug discontinuation is shown. Because of severe reduced left ventricular function in dilated cardiomyopathy, heart failure symptoms could conceal clinical signs of pulmonary amiodarone toxicity. Therefore, pulmonary function should be controlled periodically during amiodarone therapy including bronchoscopy, bronchoalveolar lavage, biopsy and measurement of diffusion capacity.
Experimental and numerical studies on the cavitation in an advanced rotational hydrodynamic cavitation reactor for water treatment (2020)

Hydrodynamic cavitation (HC) has emerged as one of the most potential technologies for industrial-scale water treatment. The advanced rotational hydrodynamic cavitation reactors (ARHCRs) that appeared recently have shown their high effectiveness and economical efficiency compared with conventional devices. For the interaction-type ARHCRs where cavitation is generated from the interaction between the cavitation generation units (CGUs) located on the rotor and the stator, their flow field, cavitation generation mechanism, and interaction process are still not well defined. The present study experimentally and numerically investigated the cavitation flow characteristics in a representative interaction-type ARHCR which has been proposed in the past. The cavitation generation mechanism and development process, which was categorized into "coinciding", "leaving", and "approaching" stages, were analyzed explicitly with experimental flow visualization and computational fluid dynamics (CFD) simulations. The changes in the cavitation pattern, area ratio, and sheet cavitation length showed high periodicity with a period of 0.5 ms/cycle at a rotational speed of 3,600 rpm in the flow visualization. The experimental and CFD results indicated that sheet cavitation can be generated on the downstream sides of both the moving and the static CGUs. The sheet cavitation was induced and continuously enlarged in the "leaving" and "approaching" stages and was crushed after the moving CGUs coincided with the static CGUs. In addition, vortex cavitation was formed in the vortex center of each CGU due to high-speed rotating fluid motion. The shape and size of the vortex cavitation were determined by the compression effect produced by the interaction. The findings of this work are important for the fundamental understanding, design, and application of the ARHCRs in water treatment.
ChemInform Abstract: AMINO ACIDS AND PEPTIDES. CLXXXVIII. ENZYMIC RESOLUTION OF Γ‐CARBOXY‐DL‐GLUTAMIC ACID (1985)

Abstract Ausgehend von dem zugänglichen Serinderivat (I) (erhalten durch Tosylierung des entsprechenden Alkohols; 51%) wird über das racemische Glutaminsäurederivat (IVa) in einer enzymatisch katalysierten, enantioselektiven Reaktion Verbindung (IVc) und daraus enantiomerenrein die Glutaminsäure (IVe) dargestellt.
Measurement of the production cross section for single top quarks in association with W bosons in proton-proton collisions at $$ \sqrt{s}=13 $$ TeV (2018)

A bstract A measurement is presented of the associated production of a single top quark and a W boson in proton-proton collisions at $$ \sqrt{s}=13 $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msqrt><mml:mi>s</mml:mi></mml:msqrt><mml:mo>=</mml:mo><mml:mn>13</mml:mn></mml:math> TeV by the CMS Collaboration at the CERN LHC. The data collected corresponds to an integrated luminosity of 35.9 fb −1 . The measurement is performed using events with one electron and one muon in the final state along with at least one jet originated from a bottom quark. A multivariate discriminant, exploiting the kinematic properties of the events, is used to separate the signal from the dominant $$ \mathrm{t}\overline{\mathrm{t}} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>t</mml:mi><mml:mover><mml:mi>t</mml:mi><mml:mo>¯</mml:mo></mml:mover></mml:math> background. The measured cross section of 63 . 1 ± 1 . 8(stat) ± 6 . 4(syst) ± 2 . 1 (lumi) pb is in agreement with the standard model expectation.
A Vertically Integrated CMOS Microsystem for Time-Resolved Fluorescence Analysis (2010)

We describe a two-chip micro-scale time-resolved fluorescence analyzer integrating excitation, detection, and filtering. A new 8×8 array of drivers realized in standard low-voltage 0.35-μm complementary metal-oxide semiconductor is bump-bonded to AlInGaN blue micro-pixellated light-emitting diodes (micro-LEDs). The array is capable of producing sample excitation pulses with a width of 777 ps (FWHM), enabling short lifetime fluorophores to be investigated. The fluorescence emission is detected by a second, vertically-opposed 16 × 4 array of single-photon avalanche diodes (SPADs) fabricated in 0.35-μm high-voltage CMOS technology with in-pixel time-gated photon counting circuitry. Captured chip data are transferred to a PC for further processing, including histogramming, lifetime extraction, calibration and background/noise compensation. This constitutes the smallest reported solid-state microsystem for fluorescence decay analysis, replacing lasers, photomultiplier tubes, bulk optics, and discrete electronics. The system is demonstrated with measurements of fluorescent colloidal quantum dot and Rhodamine samples.
First Detection Of Aminoglycosides Resistance Genes AAC(6)-IB, Ant(2)-I And AAD In Enterobacteriaceae Producing Extended-Spectrum Beta-Lactamases In Abidjan (cote Divoire) (2018)

The aim of this study was to highlight the presence of aminoglycoside resistance genes in enterobacteriaceae producing extended-spectrum beta-lactamases isolated in Abidjan. The study involved 153 enterobacteriaceae of human origin and whose identification has been confirmed by Maldi Tof-type Mass Spectrometry. The antibiotic susceptibility testing was performed by diffusion on Mueller-Hinton E agar. The beta-lactams resistance genes were characterized by real-time PCR, conventional PCR and sequenced. While the aminoglycoside resistance genes were detected through conventional PCR directly. Of these strains 90 (58.8%) were producing broad-spectrum beta-lactamase. A high resistance rate to aminoglycosides (90%), cefotaxime (95.6%), ceftriaxone (96.7%), and cefoxitin (72.2%) wa s observed in enterobacteriaceae producing extended-spectrum beta-lactamases. The aminoglycoside resistance genes found were aac (6) -Ib, ant (2 ") -I and aad at the rate of 58.9%, 8.9% and 7.8% respectively. Resistance genes to -lactams detected were blaCTX-M (96.7%), blaTEM (67.8 %) and blaSHV (27.8%). This study is the first to describe the aminoglycoside resistance genes in clinical strains of enterobacteriaceae in Abidjan.
What does it take to make a heart? (2005)

Ever increasing advances are being made in our quest to understand what it takes to direct pluripotent precursor cells to adopt a specific developmental fate. Eventually, the obvious goal is that targeted manipulation of these precursor cells will result in an efficient and reliable production of tissue-specific cells, which can be safely employed for therapeutic purposes. We have gained an incredible insight as to which molecular pathways are involved in governing neural, skeletal and cardiac muscle fate decisions. However, we still face the challenge of how to direct, for example, a cardiac fate in stem cells in the amounts needed to be employed for regenerative means. Equally importantly, we need to resolve critical questions such as: can the in vitro generated cardiomyocytes actually functionally replace damaged heart tissue? Here I will provide an overview of the molecules and signalling pathways that have first been demonstrated in embryological studies to function in cardiogenesis, and summarize how this knowledge is being applied to differentiate mouse and human embryonic stem cells into cardiomyocytes.