gebhart/patrepeval huggingface dataset:
Large scale A griotes spp. click beetle ( C oleoptera: E lateridae) invasion of crop land from field margin reservoirs (2017)

Abstract Mark–release–recapture was used to investigate the dispersal of click beetles in spring wheat or fallow fields using edge or centre field releases. Three types of pitfalls were used: gutter traps near field margins, as well as conventional pitfall traps or cross‐traps consisting of four gutter trap arms leading to a central pitfall. Capture of naturally occuring beetles was concurrently recorded. In total, 6952 marked A griotes obscurus (males and females) and A griotes lineatus (males) were released and 14.74% were recaptured at some time during the present study. Recovery rates ranged from 3.54% to 28.5%. A griotes obscurus dominated wild populations, with 4011 males and 1672 females trapped compared with 17 males and three females for A . lineatus . Males dominated early in the period, although the sex ratio tended towards equality as the season progressed. Generally, captures of A . obscurus males released in equal numbers at field edges followed a uniform distribution. There were differences for wild beetles caught in the same traps. Spatial trapping patterns of wild and marked beetles across the fields were similar. Within 19 h of release at the field edges A . obscurus males were captured &gt;30 m away. The crop type had a significant interspecific effect on trap counts for males and an intraspecific effect on A . obscurus females, reinforcing the need for caution when using trapping systems to monitor adult stages of these pests. The results of the present study demonstrate that uncropped field margins comprise sources of click beetles. We also conclude that click beetles disperse much further than reported previously.
Miniature Amperometric Self-Powered Continuous Glucose Sensor with Linear Response (2012)

Continuous glucose measurement has improved the treatment of type 1 diabetes and is typically provided by externally powered transcutaneous amperometric sensors. Self-powered glucose sensors (SPGSs) could provide an improvement over these conventionally powered devices, especially for fully implanted long-term applications where implanted power sources are problematic. Toward this end, we describe a robust SPGS that may be built from four simple components: (1) a low-potential, wired glucose oxidase anode; (2) a Pt/C cathode; (3) an overlying glucose flux-limiting membrane; and (4) a resistor bridging the anode and cathode. In vitro evaluation showed that the sensor output is linear over physiologic glucose concentrations (2-30 mM), even at low O(2) concentrations. Output was independent of the connecting resistor values over the range from 0 to 10 MΩ. The output was also stable over 60 days of continuous in vitro operation at 37 °C in 30 mM glucose. A 5-day trial in a volunteer demonstrated that the performance of the device was virtually identical to that of a conventional amperometric sensor. Thus, this SPGS is an attractive alternative to conventionally powered devices, especially for fully implanted long-term applications.
Control Stability Study of a Tailless High-Speed Tandem-Wing VTOL Vehicle Using CoFlow Jet (2023)

View Video Presentation: https://doi.org/10.2514/6.2023-4282.vid This paper numerically investigates the three-axis moment variation of a tailless tandem- wing CoFlow Jet VTOL (CFJ-VTOL) aircraft concept with high speed cruise Mach number of 0.6. The designed aircraft uses CoFlow Jet (CFJ) active flow control with a series of distributed propellers mounted above its tandem wings. The unique distributed propulsion configuration allows for efficient flight without the need for traditional control surfaces. Individually controlling the strength of the CFJ sets and propellers along the wing eliminates the need for the aircraft rudder, elevators, and ailerons. Elimination of these features reduces aircraft weight and mechanical complexity, while also improving aerodynamic efficiency by reducing drag during cruise. This paper shows that three-axis moment control can be achieved by modifying the strength of individual CFJ sets and propellers to generate roll, pitch, and yaw moments. The aircraft wings are formed by the CFJ-NACA6415 airfoil. This distributed propeller-CFJ system reduces power required during vertical takeoff and hover while also providing a very efficient cruise L/Dc = 14.44.
Filtering of coherent energy with short filters in the time‐space domain (1987)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1987Filtering of coherent energy with short filters in the time‐space domainAuthors: Eugene LichmanE. John NorthwoodEugene LichmanFiltrex Research Inc. and E. John NorthwoodNorthwood and Associates Inc.https://doi.org/10.1190/1.1892116 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InReddit Permalink: https://doi.org/10.1190/1.1892116FiguresReferencesRelatedDetails SEG Technical Program Expanded Abstracts 1987 ISSN (print):1052-3812 ISSN (online):1949-4645 Copyright: 1987 Pages: 923 publication data© 1987 Copyright © 1987 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 07 Mar 2005 CITATION INFORMATION Eugene Lichman and E. John Northwood, (1987), "Filtering of coherent energy with short filters in the time‐space domain," SEG Technical Program Expanded Abstracts : 270-272. https://doi.org/10.1190/1.1892116 Plain-Language Summary PDF DownloadLoading ...
Local CpG density affects the trajectory of age-associated epigenetic changes (2021)

Abstract DNA methylation is an epigenetic mark associated with gene repression and genome stability. Its pattern in the genome is disrupted with age and these changes can be used to statistically predict age with epigenetic clocks. Rates of aging inferred from these clocks correlate with human health. However, the molecular mechanisms underpinning age-associated DNA methylation changes are unknown. Local DNA sequence plays a strong role in programming DNA methylation levels at individual loci independently of age, but its influence on age-associated DNA methylation changes is unknown. We analysed longitudinal human DNA methylation trajectories at 345,895 CpGs from 600 individuals aged between 67 and 80 to understand the factors responsible for age-associated epigenetic changes at individual CpGs in the genome. We show that changes in methylation with age are especially apparent at 8,322 low CpG density loci. Using SNP data from the same individuals we demonstrate that DNA methylation trajectories are affected by local sequence polymorphisms at 1,487 loci with low CpG density. More generally, we find that local CpG density is a strong determinant of a CpG’s methylation trajectory and that CpGs located in low CpG density regions are particularly prone to change. Overall, our results demonstrate that local DNA sequence influences age-associated DNA methylation changes in humans in vivo . We suggest that this occurs because interactions between CpGs reinforce maintenance of methylation patterns in CpG dense regions.
[Clinical study in treating qi-deficiency and blood-stasis syndrome of angina pectoris with qi xue granule]. (1992)

(1) Effects on clinical symptoms: Total effective rate for AP: 90% in QXG group, marked effective rate and effective rate for ischemic ECG changes were 30% and 46.6% respectively. All of these were better than that of CST group significantly (P < 0.05). Besides, QXG group could alleviate symptoms including asthenia. (2) Effects on submaximal paddle work load test: QXG group could prolong the capacity of exercise (from 336.2 +/- 34.7 to 437.5 +/- 43.8 seconds, P < 0.05), magnify the work load (from 73 +/- 7.18 to 94 +/- 8.5 W, P < 0.05) and elevate the ST segment (from 0.218 +/- 0.03 to 0.176 +/- 0.03 mV) significantly in comparison with CST group, which had little change only. (3) Effects on plasma TXB2, 6-keto-PGF1 alpha (6 Kp) level and ration of TXB2/6Kp in 10 normal subjects were 165 +/- 12.1 pg/ml, 142.6 +/- 17.4 pg/ml and 1.16 +/- 0.19 pg/ml respectively, while in 36 cases AP were 390.6 +/- 14.3, 106.0 +/- 7.9 and 3.67 +/- 0.85 pg/ml respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
A New Rapid Method for Thawing Fresh Frozen Plasma (1974)

The use of fresh frozen plasma (FFP) often results in unused thawed units because of the time required to thaw FFP prior to use. A rapid thawing technique was studied, utilizing a microwave oven. Resultant levels of coagulation factors were compared with conventional slow thawing in a 37 C water bath. Mean prefreezing, rapid thaw and conventional thaw values were fibrinogen 246, 223, 238 mg/100 ml; prothrombin 101, 103, 105 per cent; factor V; 102, 79, 86 per cent; factor VIII 94, 77, 75 per cent; factor IX 103, 92, 90 per cent; factors VII/X 101, 107, 103 per cent; and factor × 84, 79, 82 per cent. No significant differences existed between rapid thawing and conventional thawing for any coagulation factor studied. Average thawing times were five minutes for rapid thawing (RT) and 25 minutes for conventional thawing. Although careful establishment of thawing time is required for each oven, microwave thawing permits better utilization of FFP for surgery and speeds delivery in emergencies, without destroying coagulation proteins.
Development of a novel plasma probe for the investigation and control of plasma‐enhanced chemical vapor deposition coating processes (2020)

Abstract A plasma probe and measuring method were developed to simultaneously determine both the electron density, n e , and floating potential in plasma‐enhanced chemical vapor deposition (PECVD) coating processes within low‐pressure plasmas. The functionality of the probe with a high deposition rate is demonstrated on the basis of examples using hexamethyldisiloxane as a precursor gas. The results show that the developed probe can determine both the n e (∼10 15 m −3 ) and the time‐varying floating potential. The results also indicate that the probe is effective for monitoring the changes in the plasma condition caused by the pressure and the gas flow rate during the coating process. This method can contribute to confirm the process and chamber conditions in PECVD processes.
Sketch it, make it (2012)

Sketch It, Make It (SIMI) is a modeling tool that enables non-experts to design items for fabrication with laser cutters. SIMI recognizes rough, freehand input as a user iteratively edits a structured vector drawing. The tool combines the strengths of sketch-based interaction with the power of constraint-based modeling. Several interaction techniques are combined to present a coherent system that makes it easier to make precise designs for laser cutters.
Wellhead Protection and Its Implications (2000)

This paper evaluates the development of a wellhead protection program for the City of Las Cruces in Southern New Mexico. The paper compares the simplified methods for wellhead delineation, such as the EPA (WHPAs) method, with more detailed three-dimensional interpretation of wellhead protection using a combination of a groundwater model and a particle tracking model. The paper describes the effects of methodology, well construction technique, hydraulics and non-homogeneity of groundwater, on the interpretation and legal and environmental implication of a capture zone. The paper describes how various conclusions and remedial actions can be taken depending on the methodology used and the interpretation of the results.
Predicting responses to platin chemotherapy agents with biochemically-inspired machine learning (2019)

The selection of effective genes that accurately predict chemotherapy responses might improve cancer outcomes. We compare optimized gene signatures for cisplatin, carboplatin, and oxaliplatin responses in the same cell lines and validate each signature using data from patients with cancer. Supervised support vector machine learning is used to derive gene sets whose expression is related to the cell line GI<sub>50</sub> values by backwards feature selection with cross-validation. Specific genes and functional pathways distinguishing sensitive from resistant cell lines are identified by contrasting signatures obtained at extreme and median GI<sub>50</sub> thresholds. Ensembles of gene signatures at different thresholds are combined to reduce the dependence on specific GI<sub>50</sub> values for predicting drug responses. The most accurate gene signatures for each platin are: cisplatin: <i>BARD1</i>, <i>BCL2</i>, <i>BCL2L1</i>, <i>CDKN2C</i>, <i>FAAP24</i>, <i>FEN1</i>, <i>MAP3K1</i>, <i>MAPK13</i>, <i>MAPK3</i>, <i>NFKB1</i>, <i>NFKB2</i>, <i>SLC22A5</i>, <i>SLC31A2</i>, <i>TLR4</i>, and <i>TWIST1</i>; carboplatin: <i>AKT1</i>, <i>EIF3K</i>, <i>ERCC1</i>, <i>GNGT1</i>, <i>GSR</i>, <i>MTHFR</i>, <i>NEDD4L</i>, <i>NLRP1</i>, <i>NRAS</i>, <i>RAF1</i>, <i>SGK1</i>, <i>TIGD1</i>, <i>TP53</i>, <i>VEGFB</i>, and <i>VEGFC;</i> and oxaliplatin: <i>BRAF</i>, <i>FCGR2A</i>, <i>IGF1</i>, <i>MSH2</i>, <i>NAGK</i>, <i>NFE2L2</i>, <i>NQO1</i>, <i>PANK3</i>, <i>SLC47A1</i>, <i>SLCO1B1</i>, and <i>UGT1A1</i>. Data from The Cancer Genome Atlas (TCGA) patients with bladder, ovarian, and colorectal cancer were used to test the cisplatin, carboplatin, and oxaliplatin signatures, resulting in 71.0%, 60.2%, and 54.5% accuracies in predicting disease recurrence and 59%, 61%, and 72% accuracies in predicting remission, respectively. One cisplatin signature predicted 100% of recurrence in non-smoking patients with bladder cancer (57% disease-free; <i>N</i> = 19), and 79% recurrence in smokers (62% disease-free; <i>N</i> = 35). This approach should be adaptable to other studies of chemotherapy responses, regardless of the drug or cancer types.
Role of microRNAs in the pathogenesis of diabetic cardiomyopathy (2017)

The morbidity of diabetes mellitus has been increasing annually. As a progressive metabolic disorder, chronic complications occur in the late stage of diabetes. In addition, cardiovascular diseases account for the major cause of morbidity and mortality among the diabetic population worldwide. Diabetic cardiomyopathy (DCM) is a type of diabetic heart disease. Patients with DCM show symptoms and signs of heart failure while no specific cause, such as coronary disease, hypertension, alcohol consumption, or other structural heart diseases has been identified. The pathogenesis of DCM is complex and has not been well understood until recently. MicroRNAs (miRs) belong to a novel family of highly conserved, short, non-coding, single-stranded RNA molecules that regulate transcriptional and post-transcriptional gene expression. Furthermore, recent studies have demonstrated an association between miRs and DCM. In the current review, the role of miRs in the pathogenesis of DCM is summarized. It was concluded that miRs contribute to the regulation of cardiomyocyte hypertrophy, myocardial fibrosis, cardiomyocyte apoptosis, mitochondrial dysfunction, myocardial electrical remodeling, epigenetic modification and various other pathophysiological processes of DCM. These studies may provide novel insights into targets for prevention and treatment of the disease.
Layered Aluminosilicate/Chromophore Nanocomposites and Their Electrostatic Layer-by-Layer Assembly (2001)

Intercalation complexes of the fluorescent dye coumarin and lamellar aluminosilicate hectorite have been prepared and studied. The nanocomplexes are characterized by molecular order and thermal stability. Optical quality films of multilayered nanocomposites of coumarin and hectorite were prepared by a layer-by-layer self-assembly technique using a cationic polyelectrolyte. These films showed characteristic strong fluorescence at 465 nm.
The induction of augmented granulocyte adherence by inflammation. Mediation by a plasma factor. (1976)

The adherence of granylocytes to surfaces, measured in vitro in nylon fiber columns, is inhibited by in vivo administration of anti-inflammatory agents. Therefore, the effect of inflammation itself was assessed in blood from patients with acute inflammatory diseases. Mean adherence in these patients was twice normal (56.4 +/- 5.6% vs. 29.4 +/- 5.2%); their plasma contained a factor that augmented adherence of normal cells to 47.5 +/- 5.6% whereas the patient's cells showed a normal level of adherence (34.0 +/- 6.8%) when resuspended in normal plasma. Although exudate fluid from exprimental inflammation also contained the augmenting factor, cells from the exudate maintained their high level of adherence after washing and suspension in normal plasma. The augmenting factor detected in plasma from patients with inflammation was not present in serum and was inactivated by heating plasma to 56 degrees C for 30 min; restoration of augmenting activity was accomplished by addition of 20% guinea pig serum to the heat-treated plasma. Because the guinea pig serum itself did not increase adherence when added to normal plasma, it appears that the augmenting factor is heat-stable, but requires a heat-labile cofactor like complement. Sephadex G-200 fractionation of inflammatory plasma showed adherence-augmenting activity in the majority of fractions, with peak activity in the fractions corresponding to approximate molecular wts of 30,000, 160,000 and 400,000.
Dormant origins licensed by excess Mcm2–7 are required for human cells to survive replicative stress (2007)

In late mitosis and early G1, Mcm2-7 complexes are loaded onto DNA to license replication origins for use in the upcoming S phase. However, the amount of Mcm2-7 loaded is in significant excess over the number of origins normally used. We show here that in human cells, excess chromatin-bound Mcm2-7 license dormant replication origins that do not fire during normal DNA replication, in part due to checkpoint activity. Dormant origins were activated within active replicon clusters if replication fork progression was inhibited, despite the activation of S-phase checkpoints. After lowering levels of chromatin-bound Mcm2-7 in human cells by RNA interference (RNAi), the use of dormant origins was suppressed in response to replicative stress. Although cells with lowered chromatin-bound Mcm2-7 replicated at normal rates, when challenged with replication inhibitors they had dramatically reduced rates of DNA synthesis and reduced viability. These results suggest that the use of dormant origins licensed by excess Mcm2-7 is a new and physiologically important mechanism that cells utilize to maintain DNA replication rates under conditions of replicative stress. We propose that checkpoint kinase activity can preferentially suppress initiation within inactive replicon clusters, thereby directing new initiation events toward active clusters that are experiencing replication problems.
DESIGN AND IMPLEMENTATION OF PROGRAMMABLE MEDIA GATEWAYS (2000)

Treating the network as a processor that can perform computation has several benefits. Processing at strategic locations in the network may reduce bandwidth requirements. Low-powered devices that are connected to the Internet can be off-loaded as well. In this paper we present Degas, a programmable media gateway system. Degas allows users to upload small programs, called deglets, into a Degas gateway to filter, transform or mix video streams from a multicast session. We describe a declarative, event-driven programming model for writing deglets. We also discuss a simple mechanism used by gateways to optimize and execute the operations specified in the deglets. Finally, a method for selecting a suitable gateway to run deglets is outlined. 1.
<title>Femtosecond infrared spectroscopy of biological processes</title> (1993)

Recent infrared spectroscopic studies of the ultrafast responses of optically triggered changes in proteins are discussed. Examples from research on bacteriorhodospin and reaction centers illustrate the potential of time resolved infrared spectroscopy in the field of protein dynamics.
The aryl hydrocarbon receptor suppresses immunity to oral squamous cell carcinoma through immune checkpoint regulation (2021)

Immune checkpoint inhibitors represent some of the most important cancer treatments developed in the last 20 y. However, existing immunotherapy approaches benefit only a minority of patients. Here, we provide evidence that the aryl hydrocarbon receptor (AhR) is a central player in the regulation of multiple immune checkpoints in oral squamous cell carcinoma (OSCC). Orthotopic transplant of mouse OSCC cells from which the AhR has been deleted (MOC1<sup>AhR-KO</sup>) results, within 1 wk, in the growth of small tumors that are then completely rejected within 2 wk, concomitant with an increase in activated T cells in tumor-draining lymph nodes (tdLNs) and T cell signaling within the tumor. By 2 wk, AhR<sup>+</sup> control cells (MOC1<sup>Cas9</sup>), but not MOC1<sup>AhR-KO</sup> cells up-regulate exhaustion pathways in the tumor-infiltrating T cells and expression of checkpoint molecules on CD4<sup>+</sup> T cells (PD-1, CTLA4, Lag3, and CD39) and macrophages, dendritic cells, and Ly6G<sup>+</sup> myeloid cells (PD-L1 and CD39) in tdLNs. Notably, MOC1<sup>AhR-KO</sup> cell transplant renders mice 100% immune to later challenge with wild-type tumors. Analysis of altered signaling pathways within MOC1<sup>AhR-KO</sup> cells shows that the AhR controls baseline and IFNγ-induced <i>Ido</i> and PD-L1 expression, the latter of which occurs through direct transcriptional control. These observations 1) confirm the importance of malignant cell AhR in suppression of tumor immunity, 2) demonstrate the involvement of the AhR in IFNγ control of PD-L1 and IDO expression in the cancer context, and 3) suggest that the AhR is a viable target for modulation of multiple immune checkpoints.
Concurrent Glossopharyngeal Neuralgia and Hemi-Laryngopharyngeal Spasm (HeLPS): A Case Report and a Review of the Literature (2019)

This review highlights that patients with symptoms compatible with HeLPS have been reported since 1926 in at least 4 languages. This additional evidence supports the growing recognition that HeLPS is another neurovascular compression syndrome. Patients with HeLPS continue to be misdiagnosed as conversion disorder. The increased recognition of this new medical condition will require neurosurgical treatment and should alleviate the suffering of these patients.
Accelerating river blindness elimination by supplementing MDA with a vegetation “slash and clear” vector control strategy: a data-driven modeling analysis (2019)

Attention is increasingly focusing on how best to accelerate progress toward meeting the WHO's 2030 goals for neglected tropical diseases (NTDs). For river blindness, a major NTD targeted for elimination, there is a long history of using vector control to suppress transmission, but traditional larvicide-based approaches are limited in their utility. One innovative and sustainable approach, "slash and clear", involves clearing vegetation from breeding areas, and recent field trials indicate that this technique very effectively reduces the biting density of Simulium damnosum s.s. In this study, we use a Bayesian data-driven mathematical modeling approach to investigate the potential impact of this intervention on human onchocerciasis infection. We developed a novel "slash and clear" model describing the effect of the intervention on seasonal black fly biting rates and coupled this with our population dynamics model of Onchocerca volvulus transmission. Our results indicate that supplementing annual drug treatments with "slash and clear" can significantly accelerate the achievement of onchocerciasis elimination. The efficacy of the intervention is not very sensitive to the timing of implementation, and the impact is meaningful even if vegetation is cleared only once per year. As such, this community-driven technique will represent an important option for achieving and sustaining O. volvulus elimination.