gebhart/patrepeval huggingface dataset:
1774: Nephron-Sparing Surgery as the New Gold Standard for T1 ≤ 7 CM) Renal Cell Carcinoma: Results of a Contemporary Ucla Series (2004)

You have accessJournal of UrologyDiscussed Poster, Wednesday, May 12, 2004, 8:00 am - 12:00 pm1 Apr 20041774: Nephron-Sparing Surgery as the New Gold Standard for T1 ≤ 7 CM) Renal Cell Carcinoma: Results of a Contemporary Ucla Series John S. Lam, Oleg Shvarts, Mehrdad Alemozaffarder, Hyung L. Kim, He-jing Wang, Allan J. Pantuck, Robert B. Smith, and Arie S. Belldegrun John S. LamJohn S. Lam More articles by this author , Oleg ShvartsOleg Shvarts More articles by this author , Mehrdad AlemozaffarderMehrdad Alemozaffarder More articles by this author , Hyung L. KimHyung L. Kim More articles by this author , He-jing WangHe-jing Wang More articles by this author , Allan J. PantuckAllan J. Pantuck More articles by this author , Robert B. SmithRobert B. Smith More articles by this author , and Arie S. BelldegrunArie S. Belldegrun More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)38966-3AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "1774: Nephron-Sparing Surgery as the New Gold Standard for T1 ≤ 7 CM) Renal Cell Carcinoma: Results of a Contemporary Ucla Series." The Journal of Urology, 171(4S), p. 469 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 171Issue 4SApril 2004Page: 469 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information John S. Lam More articles by this author Oleg Shvarts More articles by this author Mehrdad Alemozaffarder More articles by this author Hyung L. Kim More articles by this author He-jing Wang More articles by this author Allan J. Pantuck More articles by this author Robert B. Smith More articles by this author Arie S. Belldegrun More articles by this author Expand All Advertisement PDF DownloadLoading ...
Voltage-tunable dual-band InAs quantum-dot infrared photodetectors based on InAs quantum dots with different capping layers (2008)

A voltage-tunable, dual-band, InAs quantum-dot infrared photodetector (QDIP) is reported. The QDIP consists of InAs quantum dot layers with GaAs and In0.20Ga0.80As capping layers for extended middle infrared (EMIR, 6–8 µm) and long-wave infrared (LWIR, 8–12 µm) detection, respectively. Voltage-tunable single- and dual-band operations were obtained with good photoresponsivity and photodetectivity selectivity. Since the detection band of the QD FPA can be individually tuned by engineering the capping layers of the InAs QDs, this design approach offers great flexibility in detection for a given spectral region.
When bacteria target the nucleus: the emerging family of nucleomodulins (2012)

The nucleus, at the heart of the eukaryotic cell, hosts and protects the genetic material, governs gene expression and regulates the whole cell physiology, including cell division. A growing number of studies indicate that various animal and plant pathogenic bacteria can deliver factors to this central organelle to subvert host defences by directly interfering with transcription, chromatin-remodelling, RNA splicing or DNA replication and repair. Such bacterial molecules entering the nucleus, which we propose to term 'nucleomodulins', use diverse strategies to hijack nuclear processes by targeting host DNA or an array of nuclear proteins. In some cases, bacteria can even enter the nucleus. These bacterial 'nuclear attacks' might have permanent genetic or long-term epigenetic effects on the host. Studying nucleomodulins and endonuclear bacteria can thus generate new insights into long-term impacts of infectious diseases and create novel tools for biotechnological applications and for deciphering the regulation of nuclear dynamics.
Systematic analysis and nomenclature of mammalian F-box proteins (2004)

Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA; Department of Pathology, New York University School of Medicine, New York, New York 10016, USA; HUGO Gene Nomenclature Committee, Department of Biology, University College London, London, NW1 2HE, United Kingdom; Partners Center for Genetics and Genomics, Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Prevalence of Aging, Dementia, and Multimorbidity in Older Adults With Down Syndrome (2018)

Older Medicare beneficiaries in California with DS, especially those with dementia, have a high level of multimorbidity including several treatable conditions. While DS follow-up has long been confined to the pediatric sphere, we found that longevity in individuals with DS will necessitate complex adult and geriatric care. More evidenced-based and standardized follow-up could support better long-term comorbidity management and dementia care among aging adults with DS.
Inducible Bronchus-Associated Lymphoid Tissue (iBALT) attenuates pulmonary Th2 responses (2016)

Abstract Inducible bronchus-associated lymphoid tissue (iBALT) is an ectopic lymphoid tissue formed in the lung after pulmonary infection or inflammation. This local lymphoid tissue is structurally similar to conventional secondary lymphoid organs (SLOs), with separated B and T cell areas, specialized stromal cells and lymphoid dendritic cells (DCs). The presence of iBALT is typically associated with pulmonary pathology and advanced lung disease, particularly in patients with chronic obstructive pulmonary disease (COPD), rheumatoid lung disease, pulmonary fibrosis and chronic infections, suggesting that iBALT functions to exacerbate local immune responses and pathology. Here, we tested whether the presence of iBALT affected the pulmonary immune responses to allergens. We induced iBALT formation in neonatal mice by pulmonary administration of lipopolysaccharide (LPS), and when the mice were adults, sensitized and challenged them intranasally with ovalbumin (OVA). We found that mice with iBALT exhibited reduced Th2 responses, reduced eosinophil recruitment, reduced goblet cell hyperplasia and reduced mucus production. The presence of iBALT delayed the accumulation of Th2 cells and eosinophils in the lung following challenge and altered the spatial distribution of T cells in the lung. We also found that the more organized iBALT structure was, the fewer eosinophil infiltrates were observed in house dust mite (HDM)-induced allergic inflammation. Although Th2 cells are generated in mice with iBALT, they are concentrated in iBALT area and more dilute in lung parenchyma. Overall, our studies expanded the field of iBALT from observation of what happens in pulmonary diseases to determining the machinery involved in the responses.
Discovery of a Novel HDAC3 Selective Inhibitor and its Evaluation in Lymphoma Model (2015)

Histone deacetylase ( HDAC ) inhibition is a potentially attractive approach to cancer therapy. A number of HDAC inhibitors are in clinical development stages for the treatment of cancer as well as immune and inflammatory disorders. Although there are several approved HDAC inhibitors by the US FDA , they show a broad inhibitory spectrum against HDAC subfamily. Herein, we synthesized a series of novel hydroxamate analogs, and evaluated them with lymphoma cancer cell. Conclusively, we identified an HDAC3 selective inhibitor which shows good anticancer activity for the lymphoma model, as well as a good drug metabolism and pharmacokinetics ( DMPK ) profile.
Radial and Angular Electron Ejection Patterns of Two-Electron Quantum Dots in THz Fields (2020)

In this work, we develop and apply an ab-initio method to calculate the joint radial- and- angular electron distributions following the interaction of two-electron spherical quantum dots (QD) with intense terahertz pulses of subpicosecond duration. By applying the method to two QDs of different size, we could investigate two particular ionization mechanisms: the direct and the sequential two-photon double ionization. According to our results, the two ionization mechanisms show some similarity in the angular distribution patterns, whereas the corresponding radial distributions are distinctly different, associated with their joint kinetic energy spectrum. We also discuss the time-evolution of the ionization process in the context of the different nature of the interaction of the QD with the external radiation and the electron–electron correlation interactions.
New advances on Au–magnetic organic hybrid core–shells in MRI, CT imaging, and drug delivery (2021)

Magnetic nanoparticles have been widely studied for various scientific and technological applications such as magnetic storage media, contrast agents for magnetic resonance imaging (MRI), biolabelling, separation of biomolecules, and magnetic-targeted drug delivery. A new strategy on Au-magnetic nano-hybrid core-shells was applied in MRI, CT imaging, and drug delivery, which has been received much attention nowadays. Herein, the designing of different magnetic core-shells with Au in MRI and cancer treatment is studied.
Predictive Models for the Free Energy of Hydrogen Bonded Complexes with Single and Cooperative Hydrogen Bonds (2016)

In this work, we report QSPR modeling of the free energy ΔG of 1 : 1 hydrogen bond complexes of different H-bond acceptors and donors. The modeling was performed on a large and structurally diverse set of 3373 complexes featuring a single hydrogen bond, for which ΔG was measured at 298 K in CCl<sub>4</sub> . The models were prepared using Support Vector Machine and Multiple Linear Regression, with ISIDA fragment descriptors. The marked atoms strategy was applied at fragmentation stage, in order to capture the location of H-bond donor and acceptor centers. Different strategies of model validation have been suggested, including the targeted omission of individual H-bond acceptors and donors from the training set, in order to check whether the predictive ability of the model is not limited to the interpolation of H-bond strength between two already encountered partners. Successfully cross-validating individual models were combined into a consensus model, and challenged to predict external test sets of 629 and 12 complexes, in which donor and acceptor formed single and cooperative H-bonds, respectively. In all cases, SVM models outperform MLR. The SVM consensus model performs well both in 3-fold cross-validation (RMSE=1.50 kJ/mol), and on the external test sets containing complexes with single (RMSE=3.20 kJ/mol) and cooperative H-bonds (RMSE=1.63 kJ/mol).
Screening of Filamentous Fungi Having the Ability to Decolorize Molasses Pigments (1988)

The screening of filamentous fungi having the ability to decolorize molasses pigments was performed in Thailand, and some strains, belonging mainly to the class Deuteromycetes, were selected from among a total of 228 strains. Of these, nine showed decolorization yields of more than 50%, and they required different culture conditions, such as the glucose concentration, medium pH and nitrogen sources, for a high decolorization yield, respectively. The isolated strain, D90, showed the highest decolorization yield (about 93%) wfhen it was cultivated at 30°C for 8 days in a molasses pigment solution containing glucose 2.5%, yeast extract 0.2%, KH2PO4 0.1% and MgSO4-7H2O 0.05%, the pH being adjusted to 6.0. This potent strain was identical with the order Mycelia Sterilia due to the following characteristics, septate hyphae formation and no clamp connections or spores.
On the combining schemes for MIMO systems with hybrid ARQ (2009)

Multiple-input multiple-output (MIMO) systems with hybrid automatic-repeat-request (HARQ) promises high throughput with high reliability. However, combining-scheme design for such systems faces challenges, the presence of interference and the existence of multiple signal-to-interference-and-noise power ratios (SINRs). To overcome these challenges, this paper suggests to design combining schemes with the objective of directly optimizing the log-likelihood ratio (LLR) values. Using this approach, this paper proposes several combining schemes and then analyzes them based on three key design factors: decoding performance, scalability, and memory requirement. Computer simulations under the IEEE 802.16e standard settings show the performances of the proposed combining schemes, which align well with the analysis. Based on the analyses and the simulation results, this paper suggests preferable combining schemes respectively for MIMO systems with HARQ-chase combining (HARQ-CC) and HARQ-incremental redundancy (HARQ-IR).
Few-Core Spatial-Mode Multiplexers/Demultiplexers Based on Evanescent Coupling (2013)

The multiplexing and demultiplexing of the spatialmodes of few-mode fiber is demonstrated using few-core couplers. The mode combination/separation is achieved through mode-selective evanescent coupling. In particular, multiplexers/demultiplexers for three fiber modes are simulated that use either circular (fiber) or rectangular (planar) cores. The demultiplexing can be made independent of the spatial-orientations of the fiber modes by judicious choice of core configuration.
Theory and modelling activities in support of the ITER disruption mitigation system (2020)

In 2018, an international Task Force (TF) dedicated to the ITER Disruption Mitigation System (DMS) has been\nformed. The present paper summarizes Theory and Modelling (T&amp;M) activities performed within this TF. The ITER DMS is\nplanned to rely on Shattered Pellet Injection (SPI). The most critical issue, at present, is that of Runaway Electrons (REs).\nIndeed, recent T&amp;M work suggests that previously envisaged means of RE avoidance or mitigation may prove inefficient.\nHowever, RE simulations have not yet taken into account the possibly beneficial role of magnetohydrodynamic (MHD)\ninstabilities. Furthermore, new promising schemes for RE avoidance or mitigation are being investigated. These comprise,\namong others: 1) a prompt plasma dilution before the disruption by means of pure H2 SPI in order to suppress hot tail RE\ngeneration, and 2) should a RE beam form, a “cleanout” of the beam’s companion plasma, via (again) pure H2 SPI into the\nbeam, which may lead to a benign beam termination. The paper also discusses the status of 3D MHD modelling. The JOREK,\nM3D-C1\n and NIMROD codes have been extended in recent years to be able to simulate SPI. Good cooperation exists between the 3 teams, which materializes for example in useful benchmarks. Code validation on present experiments is progressing\nhand-in-hand with physics understanding. Predictions for ITER, although still at an early stage, suggest that multiple SPI may\nbe an efficient way to limit radiation asymmetries. Substantial 3D MHD modelling work is also ongoing in the areas of vertical\ndisplacement events, halo currents and electromagnetic loads. Finally, integrated modelling shows that material deposition\nfrom SPI will strongly depend on the target plasma, suggesting that SPI parameters may need to be adapted to the latter. SPI\nfor disruption mitigation poses new questions in terms of detailed pellet physics, which will be outlined.
DISCREPANCY BETWEEN PANCREATIC PROTEIN SECRETION AND CCK RELEASE IN RESPONSE TO BILE-PANCREATIC JUICE DIVERSION IN THE HYPERTROPHIED RAT PANCREAS INDUCED BY SYNTHETIC TRYPSIN INHIBITOR (2008)

Pancreatic exocrine secretion in conscious rats is mainly regulated by protease activities in the proximal intestine (luminal feedback regulation).1 Decrease in protease activities by ingestion of trypsin inhibitors (TI)s or diversion of bile-pancreatic juice (BPJ) stimulates pancreatic secretion2 and produces pancreatic hypertrophy via CCK release. Since CCK releasing factor, LCRF was purified from rat intestine,3 we determined whether the levels of LCRF, CCK, and protein secretion were synchronized to one another. Changes in pancreatic secretion, plasma CCK levels, and luminal LCRF contents produced by 2- and 4-h BPJ diversion, were determined in rats with 7-day TI treatment, and compared with controls. A diet containing 0.1% synthetic TI (ONO-3402) and a standard diet (CE-2) were fed in Wistar male rats for 7 days. After 7 day-treatment, the pancreatic wet weight was significantly higher in TI treated rats than the controls. For the experiments, on the third day of the feeding, rats were prepared with cannulas draining BPJ separately, and with a duodenal cannula and with an external jugular vein cannula. On the 7th day of the feeding, after 90 min of basal secretion with returning BPJ, BPJ were diverted. Changes in pancreatic secretions of fluid and protein were determined. After 2- and 4-h BPJ diversion, rats were sacrificed. Samples of 3-4 ml of blood were withdrawn through the venous cannula to measure plasma CCK concentrations. The proximal quarter of the small intestine was removed to measure LCRF content. The levels of LCRF and CCK were parallel (Fig. 1). Pancreatic protein secretion was higher in rats treated with TI than in controls throughout the experimental period. The plasma CCK and luminal LCRF content 4-h after BPJD was significantly lower in rats treated with TI than in controls. The hypertrophied pancreas may require a smaller dose of CCK to increase protein secretion.FIGURE 1: Changes in plasma CCK concentrations, LCRF content, and pancreatic protein secretion after 4-h BPJ diversion. *significantly different from the control values. TI; trypsin inhibitor. The numbers in the parentheses are the number of animals.
ChemInform Abstract: Asymmetric Synthesis of 1,2‐ and 1,4‐Dihydroquinolines. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Citizen-Participation Performance Evaluation for Local Governments in Mainland China, The State of Practice, Analytical Framework and Research Agenda (2009)

Nowadays, a great volume of citizen-participation (C-P for short) activities serving the purpose of performance evaluation have been initiated. Among these innovative activities, both the positive and negative comments on the significances have come out. While the criticisms were elicited from distinct points of view, the current study tried to provide a synthesizing description in order to further understand C-P evaluation. Through a case representing how in practice a typical C-P evaluation was implemented, traits were spotted to form an analytical framework that was considered helpful in identifying the key issues. Finally, based on the findings in the framework, an agenda against the further research on C-P evaluation was discussed.
Protein phosphatase PP1 is required for normal DNA methylation in Neurospora (2008)

Covalent modifications of histones integrate intracellular and extracellular cues to regulate the genome. H3 Lys 9 methylation (H3K9me) can direct heterochromatin formation and DNA methylation, while phosphorylation of H3 Ser 10 (H3S10p) drives gene activation and chromosome condensation. To examine the relationship between H3S10p, H3K9me, and DNA methylation in Neurospora crassa, we built and tested mutants of the putative H3S10 phosphatase, PP1. A PP1-impaired mutant showed increased H3S10p and selective reduction of methylation of H3K9 and DNA. Similarly, amino acid substitutions of H3S10 abolished methylation of H3K9 and DNA. Thus, H3S10 dephosphorylation by PP1 is required for DNA methylation of some loci.
Post-natal endothelial progenitor cells for neovascularization in tissue regeneration (2003)

The isolation of endothelial progenitor cells (EPCs) derived from bone marrow (BM) was an outstanding event in the recognition of 'de novo vessel formation' in adults occurring as physiological and pathological responses. The finding that EPCs home to sites of neovascularization and differentiate into endothelial cells (ECs) in situ is consistent with 'vasculogenesis', a critical paradigm well described for embryonic neovascularization, but proposed recently in adults in which a reservoir of stem or progenitor cells contributes to vascular organogenesis. EPCs have also been considered as therapeutic agents to supply the potent origin of neovascularization under pathological conditions. This review provides an update of EPC biology as well as highlighting their potential use for therapeutic regeneration.
ChemInform Abstract: PREPARATION AND REACTIONS OF ALKYL AND ARYL ISOPROPENYL CARBONATES. NOVEL ALKOXY‐ AND ARYLOXYCARBONYLATIONS OF AMINES (1979)

Abstract Mit Chlorkohlensäureestern (II) erhält man ′ aus dem Chlormercuri‐aceton (I) die Enolcarbonate (III), die mit den Aminen (IV) zu entsprechenden Urethanen (V) umgesetzt werden.
Evaluation of efficacy of oxygen-enriched oil-based gel dressing in patients who underwent surgical repair of distal hypospadias: a prospective randomised clinical trial (2020)

Postoperative dressing using oxygen-enriched oil-based gel was highly effective, promoting a faster wound healing in patients who underwent distal hypospadias repair. It reported a lower incidence of foreskin dehiscence and better foreskin retractability compared with the control group. It was cost-effective and clinically safe without allergy or intolerance to the product.
General Bottom‐Up Construction of Spherical Particles by Pulsed Laser Irradiation of Colloidal Nanoparticles: A Case Study on CuO (2011)

The development of a general method to fabricate spherical semiconductor and metal particles advances their promising electrical, optical, magnetic, plasmonic, thermoelectric, and optoelectric applications. Herein, by using CuO as an example, we systematically demonstrate a general bottom-up laser processing technique for the synthesis of submicrometer semiconductor and metal colloidal spheres, in which the unique selective pulsed heating assures the formation of spherical particles. Importantly, we can easily control the size and phase of resultant colloidal spheres by simply tuning the input laser fluence. The heating-melting-fusion mechanism is proposed to be responsible for the size evolution of the spherical particles. We have systematically investigated the influence of experimental parameters, including laser fluence, laser wavelength, laser irradiation time, dispersing liquid, and starting material concentration on the formation of colloidal spheres. We believe that this facile laser irradiation approach represents a major step not only for the fabrication of colloidal spheres but also in the practical application of laser processing for micro- and nanomaterial synthesis.
Petrogenetic grids from experimental data in the system Mn-Si-C-O-H (1974)

Experimental data in the system Mn-Si-C-O-H are reviewed and equations for equilibrium reactions among common manganese minerals are given. With these equations T-log ƒO 2 diagrams were constructed, that can be used as petrogenetic grids to evaluate the physical-chemical conditions during the metamorphism of manganese protores. The strong influence of the composition of the fluid phase on the equilibrium temperatures is emphasized. Applications to some natural metamorphic Mn-deposits are shown.