gebhart/patrepeval huggingface dataset:
Risk stratification of chromosomal abnormalities in chronic myelogenous leukemia in the era of tyrosine kinase inhibitor therapy (2016)

Clonal cytogenetic evolution with additional chromosomal abnormalities (ACAs) in chronic myelogenous leukemia (CML) is generally associated with decreased response to tyrosine kinase inhibitor (TKI) therapy and adverse survival. Although ACAs are considered as a sign of disease progression and have been used as one of the criteria for accelerated phase, the differential prognostic impact of individual ACAs in CML is unknown, and a classification system to reflect such prognostic impact is lacking. In this study, we aimed to address these questions using a large cohort of CML patients treated in the era of TKIs. We focused on cases with single chromosomal changes at the time of ACA emergence and stratified the 6 most common ACAs into 2 groups: group 1 with a relatively good prognosis including trisomy 8, -Y, and an extra copy of Philadelphia chromosome; and group 2 with a relatively poor prognosis including i(17)(q10), -7/del7q, and 3q26.2 rearrangements. Patients in group 1 showed much better treatment response and survival than patients in group 2. When compared with cases with no ACAs, ACAs in group 2 conferred a worse survival irrelevant to the emergence phase and time. In contrast, ACAs in group 1 had no adverse impact on survival when they emerged from chronic phase or at the time of CML diagnosis. The concurrent presence of 2 or more ACAs conferred an inferior survival and can be categorized into the poor prognostic group.
Overall survival benefits of first-line EGFR tyrosine kinase inhibitors in EGFR-mutated non-small-cell lung cancers: a systematic review and meta-analysis (2015)

In patients with advanced NSCLC harbouring exon 19 deletions, TKIs are associated with better OS compared with conventional chemotherapy. Future clinical trials should take exon 19 deletions and L858R as distinct disease entities and evaluate the treatment efficacy separately.
Induction of hypertrophy in cultured proximal tubule cells by extracellular NH4Cl. (1989)

Ammonia production increases in several models of renal hypertrophy in vivo. The present study was designed to determine whether ammonia can directly modulate the growth of renal cells in the absence of a change in extracellular acidity. In serum-free media NH4Cl (0-20 mM) caused JTC cells and a primary culture of rabbit proximal tubule cells to hypertrophy (increase in cell protein content) in a dose-dependent fashion without a change in DNA synthesis. Studies in JTC cells revealed that the cell protein content increased as a result of both an increase in protein synthesis and a decrease in protein degradation. Total cell RNA content and ribosome number increased after NH4Cl exposure and the cell content of the lysosomal enzymes cathepsin B and L decreased. Inhibition of the Na+/H+ antiporter with amiloride did not prevent the hypertrophic response induced by NH4Cl. The results indicate that ammonia is an important modulator of renal cell growth and that hypertrophy can occur in the absence of functioning Na+/H+ antiport activity.
Cerebral radiation necrosis with accumulation of thallium 201 on single-photon emission CT. (1996)

A patient who had previously undergone resection of a malignant glioma followed by radiation therapy was found to have a focus of a high accumulation of thallous chloride Tl 201 on single-photon emission CT scans, suggesting recurrent tumor. Resection of this area was performed and the specimen showed radiation necrosis, including such reactive changes as reactive astrocytes and lymphocytes in the necrotic tissue. This case illustrates a diagnostic pitfall in the use of 201Tl single-photon emission CT for distinguishing radiation necrosis from recurrent tumor in patients treated for malignant glioma.
VCP maintains nuclear size by regulating the DNA damage-associated MDC1–p53–autophagy axis in Drosophila (2021)

The maintenance of constant karyoplasmic ratios suggests that nuclear size has physiological significance. Nuclear size anomalies have been linked to malignant transformation, although the mechanism remains unclear. By expressing dominant-negative TER94 mutants in Drosophila photoreceptors, here we show disruption of VCP (valosin-containing protein, human TER94 ortholog), a ubiquitin-dependent segregase, causes progressive nuclear size increase. Loss of VCP function leads to accumulations of MDC1 (mediator of DNA damage checkpoint protein 1), connecting DNA damage or associated responses to enlarged nuclei. TER94 can interact with MDC1 and decreases MDC1 levels, suggesting that MDC1 is a VCP substrate. Our evidence indicates that MDC1 accumulation stabilizes p53A, leading to TER94<sup>K2A</sup>-associated nuclear size increase. Together with a previous report that p53A disrupts autophagic flux, we propose that the stabilization of p53A in TER94<sup>K2A</sup>-expressing cells likely hinders the removal of nuclear content, resulting in aberrant nuclear size increase.
Detection of bacterial infection with a fiber optic microendoscope (2011)

We present the use of fiber optic microendoscopy to image bacterial infection in the skin and lungs using an animal model. The contact probe microendoscope we have constructed has a 4 &mu;m resolution, a 750 &mu;m field of view, and a 1 mm outer diameter. Well resolved regions of bacterial infection were imaged for subcutaneous inocula of 10<sup>6</sup> to 10<sup>1</sup> CFU and intra-tracheal inocula of 10<sup>8</sup> to 10<sup>6</sup> CFU. Results reveal a linear relationship between average fluorescence and CFU, suggesting potential for using this device for quantitative analysis. Detection limits of 10<sup>4</sup> CFU for skin samples and 10<sup>7</sup> CFU for lung tissue were determined. In addition, bacteria were also qualitatively visible in lung tissue down to 10<sup>6</sup> CFU. Confocal imaging was used to confirm the presence of bacteria in tissue samples.
Nanomaterial processing strategies in functional hybrid materials for wastewater treatment using algal biomass (2017)

Abstract Algal cultivation has tremendous potential in wastewater treatment, and its simultaneous biomass production has advantages for the production of value added products such as biodiesel, fertilizers and pharmaceuticals. Some obstacles to obtaining a productive biological water treatment and bioenergy system are the harvesting and processing of biomass. Such issues can be addressed using nano‐bio hybridization approaches by simplifying the microbial harvesting step along with increasing the efficiency of wastewater treatment. This review highlights studies within our research group that are based on the fabrication of functional hybrid materials using algal biomass, including: (i) electrospun nanofibers; (ii) laminar nanomaterials; and (iii) magnetic nanoparticles impregnated in a polymer. All of these techniques have been used for the removal of waste pollutants such as nitrate and phosphate ions. The multidisciplinary techniques have potential to provide effective algal culture systems for industrial applications, while having a significant impact on wastewater treatment. © 2017 Society of Chemical Industry
The viscosity of a fluid containing small drops of another fluid (1932)

Abstract The viscosity of a fluid in which small solid spheres are suspended has been studied by Einstein as a problem in theoretical hydrodynamics. Einstein’s paper gave rise to many experimental researches on the viscosity of fluids containing solid particles, and it soon became clear that though complete agreement with the theory might be expected when the particles are true sphered, some modification is necessary when the particles are flattened or elongated. The theory of such systems was developed by G. B. Jeffery, who calculated the motion of ellipsoidal particles in a viscous fluid and their effect on the mean viscosity. Some of his conclusions have been verified by observation. So far no one seems to have extended Einstein’s work to liquids containing small drops of another liquid in suspension. The difficulties in the way of a complete theory when solid particles are replaced by fluid drops are almost insuperable, partly because the correct boundary conditions are not known, and partly because a fluid drop would deform under the combined action of viscous forces and surface tension. Even if the boundary conditions were known to be those commonly used in hydrodynamical theory, the calculation of the shape of the deformed drop would be exceedingly difficult. When the radius of the suspended drops or the velocity of distortion of the fluid are small, surface tension may be expected to keep them nearly spherical, and in that case Einstein’s analysis may be extended so as to include the case of liquid drops.
16 Iatrogenic catheter induced coronary artery dissection: incidence, management and outcomes (2017)

&lt;sec&gt;&lt;st&gt;Background&lt;/st&gt; Iatrogenic catheter induced coronary artery dissection is a rare but life threatening complication. The incidence has been reported to be 0.1%. &lt;/sec&gt; &lt;sec&gt;&lt;st&gt;Objective&lt;/st&gt; To estimate the incidence, management options, outcomes and long term prognosis of this rare complication. &lt;/sec&gt; &lt;sec&gt;&lt;st&gt;Methods&lt;/st&gt; The procedural records of 43 359 patients undergoing coronary angiography (diagnostic and percutaneous coronary intervention) from April 2008 to August 2016 were reviewed using Centricity (local database) and BCIS records. &lt;/sec&gt; &lt;sec&gt;&lt;st&gt;Results&lt;/st&gt; Iatrogenic catheter induced coronary artery dissection occurred in 36/43,359 cases (0.083%). The mean age was 64 years and 52.8% were females. Nineteen cases (52.8%) were during elective procedures; twenty-four cases (66.7%) were performed through radial approach and RCA dissections accounted for 58.3% of cases. Two-thirds (66.7%) of the cases involved a guide catheter engagement (p=0.0451). The majority was managed percutaneously with bail-out stenting (80.5%), three patients with CABG and the remaining four were treated conservatively. In-hospital outcomes were favourable with 34/36 patients discharged (one died on the way to theatre and one following percutaneous coronary intervention). Kaplan-Meier cumulative survival estimated 6.1% mortality at one year (all early) but no further events out to 5 years. &lt;/sec&gt; &lt;sec&gt;&lt;st&gt;Conclusion&lt;/st&gt; Iatrogenic catheter induced coronary artery dissection is rare but serious complication of coronary angiography. Timely recognition and prompt bail-out stenting is a feasible option and should be considered early to facilitate good outcomes. &lt;/sec&gt;
Longitudinal persistence with secondary prevention therapies relative to patient risk after myocardial infarction (2015)

High-risk patients with AMI have a lower likelihood of persistently taking prescribed medications post discharge as compared with low-risk patients. Continued efforts are needed to improve the use of guideline-directed medications in high-risk patients.
Continuous adjoint method for Air Traffic Flow Management (2006)

This article develops a model of air traffic flow using an Eulerian description with hyperbolic partial differential equations. Existence and uniqueness (well-posedness) of a solution to the system of partial differential equations on a network is established. Subsequently, an optimal control problem is studied with the junction coefficients as control variables. We use a continuous adjoint approach and we implement it on a network with 16 links and 5 junctions, demonstrating the computational efficiency of this method
Examination of Roller-Integrated Continuous Compaction Control on Colorado Test Site (2012)

Roller-integrated continuous compaction control can improve earthwork quality assurance in the United States; therefore, it is receiving considerable attention. Most preliminary specifications that are being evaluated are based on specifications from Austria, Germany, and Sweden. In general, the European specifications encompass either of two approaches: (a) spot testing in roller-identified weak areas or (b) calibrating roller-measured values to spot test values. A pilot implementation on an active earthwork construction site in Colorado showed spot testing roller-identified weak zones represented an incremental progression from the current methods employed in the United States. The calibration option was shown to be labor intensive, and the results presented here indicate that the initial time investment may not be justifiable. Implementation of the calibration option is further complicated because it is a significant departure from current methods. An analysis of the spot-testing option showed that if a similar level of quality acceptance is desired, then current requirements for quality assurance based on density spot testing may have to be lowered for quality assurance to be based on continuous compaction control.
Unsupervised learning for graph matching (2009)

Graph matching is an important problem in computer vision. It is used in 2D and 3D object matching and recognition. Despite its importance, there is little literature on learning the parameters that control the graph matching problem, even though learning is important for improving the matching rate, as shown by this and other work. In this paper we show for the first time how to perform parameter learning in an unsupervised fashion, that is when no correct correspondences between graphs are given during training. We show empirically that unsupervised learning is comparable in efficiency and quality with the supervised one, while avoiding the tedious manual labeling of ground truth correspondences. We also verify experimentally that this learning method can improve the performance of several state-of-the art graph matching algorithms.
Decentralised Active Perception in Continuous Action Spaces for the Coordinated Escort Problem (2023)

We consider the coordinated escort problem, where a decentralised team of supporting robots implicitly assist the mission of higher-value principal robots. The defining challenge is how to evaluate the effect of supporting robots' actions on the principal robots' mission. To capture this effect, we define two novel auxiliary reward functions for supporting robots called satisfaction improvement and satisfaction entropy, which computes the improvement in probability of mission success, or the uncertainty thereof. Given these reward functions, we coordinate the entire team of principal and supporting robots using decentralised cross entropy method (Dec-CEM), a new extension of CEM to multi-agent systems based on the product distribution approximation. In a simulated object avoidance scenario, our planning framework demonstrates up to two-fold improvement in task satisfaction against conventional decoupled information gathering.The significance of our results is to introduce a new family of algorithmic problems that will enable important new practical applications of heterogeneous multi-robot systems.
Correspondence Comment on the paper “ simplification of z-transfer functions by continued fractions ” (1975)

"Correspondence Comment on the paper “ simplification of z-transfer functions by continued fractions ”." International Journal of Control, 21(4), pp. 701–702
Constant depth circuits, Fourier transform, and learnability (1989)

Boolean functions in AC/sup O/ are studied using the harmonic analysis of the cube. The main result is that an AC/sup O/ Boolean function has almost all of its power spectrum on the low-order coefficients. This result implies the following properties of functions in AC/sup O/: functions in AC/sup O/ have low average sensitivity; they can be approximated well be a real polynomial of low degree; they cannot be pseudorandom function generators and their correlation with any polylog-wide independent probability distribution is small. An O(n/sup polylog(/ /sup sup)/ /sup (n)/)-time algorithm for learning functions in AC/sup O/ is obtained. The algorithm observed the behavior of an AC/sup O/ function on O(n/sup polylog/ /sup (n)/) randomly chosen inputs and derives a good approximation for the Fourier transform of the function. This allows it to predict with high probability the value of the function on other randomly chosen inputs.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
ANTIGENIC AND GENETIC RELATIONSHIPS AMONG RIFT VALLEY FEVER VIRUS AND OTHER SELECTED MEMBERS OF THE GENUS PHLEBOVIRUS (BUNYAVIRIDAE) (2007)

Preliminary serologic data indicated that two South American phleboviruses (Belterra virus [BELTV] and Icoaraci virus [ICOV]) may be related to Rift Valley fever virus (RVFV), an African phlebovirus that causes severe hepatitis and hemorrhagic fever in humans. To further define this relationship and to investigate the underlying genetic basis, comparative serologic and genetic sequence analyses were performed with RVFV and five other New World phleboviruses (ICOV, BELTV, Salobo virus, Joa virus, and Frijoles virus). Serologically, a one-way cross reaction was confirmed between antibodies against these New World viruses and RVFV antigen. In contrast, phylogenetic analysis demonstrated clear separation of these viruses from RVFV, into distinct phylogenies, based on sequences of the small, medium, and large RNA segments.
Processing of piezocomposites by fused deposition technique (2002)

The Fused Deposition technique was used to form piezoelectric ceramic-polymer composites with various architectures. The Fused Deposition technique is a solid freeform fabrication (SFF) process where a 3-D object is built from a 1.75 mm diameter filament fed into a heated extruder head capable of moving in the X-Y direction. The head extrudes fine beads (roads) of material onto a fixtureless platform capable of moving in the Z-direction. In this work, two different manufacturing routes, fused deposition modeling (FDM/sup TM/) and fused deposition of ceramics (FDC), were use to process lead-zirconate-titanate (PZT) ceramic/polymer composites. In the FDM/sup TM/ method, polymer molds with various connectivities were fabricated. Molds were infiltrated with a PZT slurry and dried. For the FDC method, PZT-binder filaments with 50-55 volume % solids loading were extruded and then used as a feed material to fabricate green ceramic structures. The structures were subjected to a binder burn out cycle and sintered. The composite fabrication was completed by embedding the sintered structures in an epoxy polymer. Composites were cut, polished, electroded and poled for electromechanical characterization. Composites with features as fine as 50 /spl mu/m were fabricated using these methods. Several novel composites with structures which can not be formed by standard methods will be shown and the electromechanical properties will be presented.
Synthesis of Penicillin Analogs, (---)-Methyl 6-epi-6-Bromobisnorpenicillanate and (+-)-Methyl 6-epi-6-Bromopenicillanate. (1976)

The [(4-methoxycarbonylthiazolidino)carbonyl-dihalomethyl]phenylmercury compounds 2a,b and 5a,b have been synthesized. When heated in refluxing bromobenzene they form halogenated penicillin analogs. (--)-Methyl 6-epi-6-bromobisnorpenicillinate (3a) and methyl 6-epi-6-bromopenicillinates (6a,b) have been prepared and isolated.
Modularity in HM&E Systems (1995)

ABSTRACT This paper will briefly discuss the philosophy of the ATC program and describe in detail three hull, mechanical and electrical (HM&amp;E) prototype module efforts and lessons learned. In addition, the paper will identify benefits for using common modules, challenges to the use of common modules, and future modularity efforts of the ATC program.
Développement d’une méthode de mesure de la permeabilité au gaz de milieux faiblement poreux en régime transitoire : étude d’une membrane plane micrométrique (2017)

International audience
Tyrosine phosphorylation of glycoproteins in the adult and developing rat brain (1994)

The tyrosine phosphorylation of glycoproteins in the adult and developing rat brain was investigated. Immunoblotting with anti-tyr(P) antibodies identified a glycoprotein with an apparent Mr of 180,000 (GP180) as the major tyrosine-phosphorylated protein in the concanavalin A (con A)-binding fraction prepared from forebrain homogenates. This glycoprotein had the same electrophoretic mobility as the postsynaptic density (PSD)-associated glycoprotein PSD-GP180. Tyrosine-phosphorylated GP180 was enriched 24-fold in isolated PSDs relative to homogenates. Digestion with endoglycosidase F/N-glycosidase F demonstrated that GP180 present in total homogenates and PSD-GP180 present in isolated PSDs contained similar amounts of N-linked oligosaccharide suggesting that they are the same glycoprotein. The tyrosine phosphorylation of GP180 in homogenates varied between brain regions with the highest levels occurring in cortical areas and the amygdala and low or undetectable amounts being present in hindbrain regions. Incubation of homogenates with adenosine triphosphate (ATP) resulted in the tyrosine phosphorylation of GP180 in all regions examined except the cerebellum and identified a second con A-binding glycoprotein, GP110, which was phosphorylated on tyrosine. GP180 was not phosphorylated on tyrosine following the incubation of cerebellar homogenate, synaptic membranes, or PSDs and ATP. Tyr(P)-GP180 was not detected prior to the onset of synaptogenesis, increased in parallel with the formation of synapses during the first 4 weeks of postnatal development of the frontal cortex and hippocampus, and then decreased 50-60% to adult levels. The results suggest that GP180 corresponds to the PSD glycoprotein PSD-GP180 and are consistent with a role for this glycoprotein in synaptic development and signal transduction at the synapse.
[Bacteriologic study of acute otitis media in hospitals and private practice]. (1989)

The authors report the results of the study of 435 bacteriological samples taken in children presenting with acute otitis media, in the out-patient department of ENT at the hospital Bretonneau (Paris) and in Valognes (Manche) from October 1981 to September 1987. Three bacterial organisms prevailed: Haemophilus (37 and 22% respectively), S. pneumoniae (25 and 7%) and Staphylococcus (16 and 17%). Pseudomonas was fairly frequent in cases with otorrhea, even when recent. Comparison with other studies shows the clear progression of the incidence of Haemophilus in acute otitis media. The percentage of the strains secreting a beta-lactamase was 17% whether the children live in the country or in town. The frequency of S. pneumoniae was independent of age but was clearly lower in cases with prolonged or relapsing otitis. According to these results, the authors discuss the therapeutic strategy for acute otitis media. Amoxicillin still remains the antibiotic of choice. In case of persisting or relapsing otitis, the bacteriological examination will allow choosing the best adapted antibiotic: first generation cephalosporin, clavulanic acid and amoxicillin or trimethoprime and sulfamethoxazole.