gebhart/patrepeval huggingface dataset:
Signaling from G Protein-coupled Receptors to the c-jun Promoter Involves the MEF2 Transcription Factor (1997)

The c-Jun amino-terminal kinases (JNKs) are a subfamily of mitogen-activated protein kinases that phosphorylate c-Jun and ATF2, and it has been postulated that phosphorylated c-Jun enhances its own expression through AP-1 sites on the c-jun promoter. In this study, we asked whether signals activating JNK regulate the c-jun promoter. Using NIH 3T3 cells expressing G protein-coupled m1 acetylcholine receptors as an experimental model, we have recently shown that the cholinergic agonist carbachol, but not platelet-derived growth factor, potently elevates JNK activity. Consistent with these findings, carbachol, but not platelet-derived growth factor, increased the activity of a c-jun promoter-driven reporter gene (for chloramphenicol acetyltransferase). However, coexpression of JNK kinase kinase (MEKK) effectively increased JNK activity, but resulted in surprisingly limited induction of the c-jun promoter. This raised the possibility that pathway(s) distinct from JNK control the c-jun promoter, and prompted us to explore which of its regulatory elements participate in transcriptional control. We observed that deletion of the 3' AP-1 site diminished chloramphenicol acetyltransferase activity in response to carbachol, but only to a limited extent. In contrast, deletion of a MEF2 site dramatically reduced expression, and deletion of both the MEF2 and 3' AP-1 sites abolished induction. Furthermore, cotransfection with MEF2C and MEF2D cDNAs potently enhanced the activity of the c-jun promoter in response to carbachol, and stimulation of m1 receptors, but not direct JNK activation, induced expression of a MEF2-responsive plasmid. Taken together, these data strongly suggest that MEF2 mediates c-jun promoter expression by G protein-coupled receptors through a yet to be identified pathway, distinct from that of JNK.
Studies on the Effects of Saline Aerosols of Cooling Tower Origin on Plants (1977)

A research program was undertaken to develop information that could be used to estimate the risk of adverse effects of saline cooling tower drift on native and cultivated flora in the Indian Point, New York area. Eleven species of woody plants were exposed at 85 % relative humidity to a saline mist with 95% of the particles between 50 and 150 nm in diameter. Three biological factors—stage of development, species, and phenotype—determined the susceptibility of plants to saline aerosols when the occurrence of any lesion on the foliage was used as a measure of response. The effects of stage of development on the incidence and severity of foliar lesions depended upon the kind of plant. In deciduous woody species, the youngest leaves were most susceptible, but in conifers, the year-old needles were most susceptible. Canadian hemlock was the most susceptible species and witch hazel was the least susceptible. Median effective doses for these two species, although undetermined, could be more than 100-fold different (less than 2.4, the lowest used, and greater than 264 ng CI cm-2, respectively). Other species, ranked in decreasing order of susceptibility were: white ash, white flowering dogwood, forsythia, chestnut oak, silk tree, black locust, red maple, eastern white pine, and golden rain free. Phenofypic variation within a species was not so great—within a 10 to 20-fold increase in dose the incidence of injury went from 0 to 100%. Exposures with bush bean showed that the relative humidity (RH) during or after the exposure period affected the incidence of saline induced foliar injury. A change from 50 to 85% RH doubled the effectiveness of the saline mist. It was also found that compared to particles between 50 and 150 jum in diameter, an increase in the fraction of particles above 150 /xm increased the toxicity of the mist.
Assessment of Chimpanzee Adenovirus Serotype 63 Neutralizing Antibodies Prior to Evaluation of a Candidate Malaria Vaccine Regimen Based on Viral Vectors (2014)

ABSTRACT Prior to a chimpanzee adenovirus-based (ChAd63) malarial vaccine trial, sera were collected to assess ChAd63-specific neutralizing antibody titers in Banfora (Burkina Faso). The low neutralizing antibody titers reported in both adults and children (median titers, 139.1 and 35.0, respectively) are encouraging for the potential use of ChAd63 as a malarial vaccine vector.
Saying What You're Looking For: Linguistics Meets Video Search (2015)

We present an approach to searching large video corpora for clips which depict a natural-language query in the form of a sentence. Compositional semantics is used to encode subtle meaning differences lost in other approaches, such as the difference between two sentences which have identical words but entirely different meaning: The person rode the horse versus The horse rode the person. Given a sentential query and a natural-language parser, we produce a score indicating how well a video clip depicts that sentence for each clip in a corpus and return a ranked list of clips. Two fundamental problems are addressed simultaneously: detecting and tracking objects, and recognizing whether those tracks depict the query. Because both tracking and object detection are unreliable, our approach uses the sentential query to focus the tracker on the relevant participants and ensures that the resulting tracks are described by the sentential query. While most earlier work was limited to single-word queries which correspond to either verbs or nouns, we search for complex queries which contain multiple phrases, such as prepositional phrases, and modifiers, such as adverbs. We demonstrate this approach by searching for 2,627 naturally elicited sentential queries in 10 Hollywood movies.
Laboratory measurement of electrification of wind‐blown sands and simulation of its effect on sand saltation movement (2003)

This article presents a measurement of electrification generated by wind‐blown sands in a field wind tunnel and a numerical methodology to simulate the effect of electrification on the sand saltation movement after the mutual couple interaction between the sand movement and the wind flow is taken into account. The measured data of electric charge on the “uniform” sands in the wind‐tunnel tests show that the sign of electric charge, either negative or positive, is mainly dependent on the diameter size of sand particles, i.e., negative charge is gained when the diameter is smaller than 250 μm and positive charge is obtained if the diameter is larger than 500 μm, and that for both “uniform” and mixed sands, the average charge‐to‐mass ratio decreases with increasing the wind velocity, and increases with height from sand bed. Meanwhile, the measurement of electric field in wind‐sand cloud related to the electric charge displays that the magnitude of electric field increases generally as the wind velocity and the height increase, and the direction of the field is always upwardly vertical to the Earth's surface, which is opposite to that of the fair‐weather field. In order to exhibit the effect of electrification on sand saltation movement, a theoretical model by considering the mutual coupling interaction between wind flow and sand movement is proposed after the electric force exerted on the moving sands is considered. Through solving the nonlinear coupling dynamic equations by a proposed program, the effect of electrification on sand saltation motion, e.g., trajectory, is discussed quantitatively. After that, its effect on wind‐sand transport flux, sand ejecta flux, and wind profile is also displayed. The results show that the prediction for the Bagnold's kink is good agreement with the measurement in literature.
Oral history interview with Glenn Henry (2001)

Glenn Henry begins by briefly outlining his education and early work career prior to joining IBM.The majority of the interview focuses on Henry's work as a software systems engineer and manager at IBM in the 1970s.Henry was centrally involved in the software development and hardware definitions for IBM's early Midrange Series computers.He had managerial roles at IBM San Jose and IBM Boca Raton, before leading a large team at the home of IBM Midrange Series hardware and software development, IBM Rochester.He details the programming effort for the operating system on System 3, the incremental advance with System 32, and the quantum leap IBM took with the development of System 38, a system Henry proposed -and one where the software was largely driving the definition of the hardware.The interview is particularly rich in detailing the relationship between software and hardware development as well as the technical and managerial successes and challenges with System 38.This is an oral history with Glenn Henry in Austin, Texas, on August 7, 2001, conducted under the auspices of the National Science Foundation.Frana: Thanks for meeting with me Glenn.You said on the phone that your work at IBM was an important story that needed to be told.Where exactly does that story begin?What education and experiences guided you when you were young?Henry: I'll tell you very quickly.I started going to college when I was very young, at age fifteen.It was part of the Sputnik Acceleration Program and I went to the University of California, which is right next door to where I grew up.I remember seeing an IBM 650 computer there.This was in 1958, this system fascinated me.But anyway, a long story, after three years I dropped out of the university and flew helicopters which was my love at that time.I worked as a helicopter pilot at nineteen.For a variety of reasons, I quit that and went to work at Shell Development as a lab technician in 1973.The week I arrived, they got a new computer, an IBM 7094.And no one there knew how to do anything with it.So I was appointed as the junior flunkie to go figure it out.So in six months I was sort of running the place.No one
Lithium Chloride and Ammonia Complexes (1928)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLithium Chloride and Ammonia ComplexesS. C. CollinsS. C. CollinsMore by S. C. Collins and F. K. CameronF. K. CameronMore by F. K. CameronCite this: J. Phys. Chem. 1928, 32, 11, 1705–1716Publication Date (Print):November 1, 1928Publication History Published online1 May 2002Published inissue 1 November 1928https://doi.org/10.1021/j150293a006Request reuse permissionsArticle Views443Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (478 KB) Get e-Alerts
ANTHEM Code Simulations Of B-field Generation And Double-foil Collisions In Laser-matter Interactions (1991)

The 2D multi-fluid implicit simulation code ANTHEM has been improved to model two challenging laser-matter interaction problems: 1) Optimized Spontaneous Magnetic Field Generation. We look at laser illuminated foils struck with high intensity long wavelength beams so as to generate copious suprathermal electrons. A high density "collector" element is placed nearby to provide an external return path for the current, ultimately to generate a large external magnetic field. No field or note has been recorded for a collisionless collector. Results from simulations in which the suprathermals encounter scatter and drag in the collector will be discussed. 2) Double-foil Collisions-ANTIIEM solves Maxwell's equations implicitly with either an Eulerian fluid or PlC particle representation for the various plasma elements. Until recently, the code has allowed for two separate electron components (background electrons and supratherrnals), and a single ion component. ANTHEM is now being augmented to permit two separate ion components as well - to enable detailed 2D studies or the interacting blowoff from laser illuminated foils as a function or the ion-ion mean free path. Progress toward this objective will be outlined.
Multi-slot semantics for natural-language call routing systems (2007)

Statistical classification techniques for natural-language call routing systems have matured to the point where it is possible to distinguish between several hundreds of semantic categories with an accuracy that is sufficient for commercial deployments. For category sets of this size, the problem of maintaining consistency among manually tagged utterances becomes limiting, as lack of consistency in the training data will degrade performance of the classifier. It is thus essential that the set of categories be structured in a way that alleviates this problem, and enables consistency to be preserved as the domain keeps changing. In this paper, we describe our experiences of using a two-level multi-slot semantics as a way of meeting this problem. Furthermore, we explore the ramifications of the approach with respect to classification, evaluation and dialogue design for call routing systems.
ChemInform Abstract: Mechanochemical Iridium(III)‐Catalyzed C—H Bond Amidation of Benzamides with Sulfonyl Azides under Solvent‐Free Conditions in a Ball Mill. (2016)

Abstract The mechanochemical activation enables the formation of an iridium species that catalyzes the ortho‐selective amidation of benzamides with various sulfonyl azides in excellent yields within short times.
Comparison of Anterior Segment Measurements between Dual and Single Scheimpflug Camera (2016)

Purpose: To assess the degree of agreement of two rotating Scheimpflug cameras, Galilei G6 and Pentacam HR, in measuring corneal refractive power (K), anterior chamber depth (ACD), and central corneal thickness (CCT). Methods: Measurement agreement was assessed in 40 eyes of 40 outpatients at our hospital. Measurements of anterior and posterior corneal refractive power (K), ACD, and CCT were compared between the Galilei G6 and Pentacam HR. Results: For Galilei G6 (4 mm), Pentacam HR (3 mm) and Pentacam HR (4 mm), the anterior corneal refractive powers (K) were 44.35 1.38 D, 44.09 1.32 D, and 44.12 1.35 D, respectively, and the posterior corneal refractive powers (K) were 6.39 0.23 D, 6.45 0.23 D, 6.45 0.22 D. The differences in the results were statistically significant. The average ACD measurements using Galilei G6 and Pentacam HR were 3.26 0.42 mm and 3.17 0.42 mm, respectively, and the average CCT measurements were 556.65 30.12 m and 553.78 29.42 m. The differences in the measurements were statistically significant. In addition, ACD 95% limits of agreement (LoA) between Galilei G6 and Pentacam HR were in the range of -0.14~0.32 mm, and CCT 95% LoA were in the range of -12.54~18.29 m. Conclusions: There were significant differences in measurements of anterior and posterior corneal refractive power (K), ACD, and CCT between the two cameras. Agreement analysis suggests that Galilei G6 and Pentacam HR should not be used interchangeably.
Instrumental photon activation analysis using the linear accelerator at the Naval Postgraduate School (1982)

Charcoal, charcoal residue, potting soil, aluminum foil, bismuth germanate, and petroleum samples have been investigated using instrumental photon activation analysis (i.e., no radiochemistry). The major and minor elements routinely observed by this nondestructive method were: C, C1, Ca, Fe, Mg, Si, and K. A compreshensive review of the principles of IPAA was also included in the study. The principles were applied to a theroetical analysis of an oil sample in which the trace element concentrations were known. It was concluded that IPAA is a highly sensitive technique which could be used to fingerprint oils. (Author)
Acute promyelocytic leukemia: treatment results during a decade at Memorial Hospital (1989)

Fifty-seven adult patients with acute promyelocytic leukemia (APL) were treated between 1974 and 1984 with daunorubicin (DNR) or 4-(9- acridinylamino)methanesulfan-m-anisidide (AMSA) in combination with arabinosylcytosine (Ara-C) and 6-thioguanine (TG); they also received prophylactic heparin. Forty-one patients (72%) achieved complete remission (CR), including 11 of 12 patients who received the AMSA- containing regimen. The incidence of early fatal hemorrhage was 14%, lower than that of earlier studies or other published reports. Elevated WBC and serum lactate dehydrogenase levels at diagnosis were associated with an increased incidence of life-threatening hemorrhage and shorter remission duration. Advanced age was an unfavorable prognostic factor for male patients. Both DNR and AMSA in combination protocols are effective treatments for APL. The incidence of CR is similar to that achieved in other types of acute nonlymphoblastic leukemia (ANLL) with the same protocols, but the median duration of remission is significantly longer in APL (24 v 9 months) and the percentage of remissions longer than 60 months is also higher in APL (35% v 5%).
Genistein suppresses leptin‐induced proliferation and migration of vascular smooth muscle cells and neointima formation (2016)

Abstract Obesity is a strong risk factor for the development of cardiovascular diseases and is associated with a marked increase in circulating leptin concentration. Leptin is a peptide hormone mainly produced by adipose tissue and is regulated by energy level, hormones and various inflammatory mediators. Genistein is an isoflavone that exhibits diverse health‐promoting effects. Here, we investigated whether genistein suppressed the atherogenic effect induced by leptin. The A10 cells were treated with leptin and/or genistein, and then the cell proliferation and migration were analysed. The reactive oxygen species ( ROS ) and proteins levels were also measured, such as p44/42 MAPK , cell cycle‐related protein (cyclin D1 and p21) and matrix metalloproteinase‐2 ( MMP ‐2). Immunohistochemistry and morphometric analysis were used for the neointima formation in a rat carotid artery injury model. Genistein (5 μM) significantly inhibited both the proliferation and migration of leptin (10 ng/ml)‐stimulated A10 cells. In accordance with these finding, genistein decreased the leptin‐stimulated ROS production and phosphorylation of the p44/42 MAPK signal transduction pathway. Meanwhile, genistein reversed the leptin‐induced expression of cyclin D1, and cyclin‐dependent kinase inhibitor, p21. Genistein attenuated leptin‐induced A10 cell migration by inhibiting MMP ‐2 activity. Furthermore, the leptin (0.25 mg/kg)‐augmented neointima formation in a rat carotid artery injury model was attenuated in the genistein (5 mg/kg body weight)‐treated group when compared with the balloon injury plus leptin group. Genistein was capable of suppressing the atherogenic effects of leptin in vitro and in vivo , and may be a promising candidate drug in the clinical setting.
Fast realization of the LADT ECG data compression method (1994)

The system clock in the authors' Intel 80c31-based Holter recorder is 12 MHz, and thus it takes tens of milliseconds to obtain the d/sub k/ at instant k. Therefore, it is impossible to apply the original linear approximation distance thresholding (LADT) algorithm in real time. With the authors' improved algorithm it takes about one ms to calculate /spl verbar/a/sub adm//spl verbar/=/spl sigma//spl middot/(1+(a/t)/sup 2/)/sup 1/2/. Though it is much faster to fulfill a linear segment approximation by the improved algorithm than by the original one, it is still difficult directly to apply the improved algorithm in a real-time system. However, it takes only two microseconds to get /spl verbar/a/sub adm//spl verbar/ by look-up in the error threshold table. In this way, about one millisecond is needed to complete a linear segment approximating (about 50 points). It can be seen that the fast realization scheme using the error threshold table not only preserves the high compression ratio and low distortion advantages of the LADT algorithm, but also makes possible the application of the LADT algorithm in real-time.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Calculation of Polarization Using a Density Functional Method with Localized Charge (2000)

A density functional method, which represents the total charge density as a sum of self-consistently determined localized densities, is described. While this approach is generally less accurate than conventional band-structure methods, it offers a relatively simple interpretation of polarization and related properties. The method is illustrated with results for NaCl, MgO, and AlP.
Knowledge and Object-Oriented Approach for Interoperability of Heterogeneous Information Management Systems (2002)

For the interoperability of heterogeneous information management systems, schema mapping approaches have been used to build a unified view. The schema mapping approach offers full transparencies and is very powerful from the user’s point of view. However, the traditional mapping approach needs to be strengthened for information management systems that have non-traditional data types, no schema, or incompatible schemas. We have incorporated numerous concepts and constructs associated with the knowledge and object-oriented paradigm such as abstract views with a set of procedures, encapsulation, inheritance and class composition hierarchies to resolve the above problem. This extension also accommodates the ability to determine and explicitly represent the semantics in the schema. Additionally, we have outlined a query processing method using the unified view. We are currently developing a prototype to support seamless access to structured data and unstructured data managed by different information management systems.
Exploration of a physiologically-inspired hearing-aid algorithm using a computer model mimicking impaired hearing (2016)

The hearing-aid algorithm affected the impaired hearing profile of the model to approximate a normal hearing profile. Qualitatively similar results were found with the impaired listeners' hearing profiles.
New active capacitor voltage balancing method for five-level stacked multicell converter (2016)

This paper proposes a new active capacitor voltage balancing method for five-level stacked multicell converter which is fully implemented using the logic-form equations. The proposed active voltage balancing method measures load current and flying capacitor voltages in order to generate the appropriate switching states to produce the required output voltage level as well as to balance the flying capacitor voltages at their reference values. Output voltage of the stacked multicell converter controlled with proposed active voltage balancing method can be modulated with any pulse-width-modulation techniques such as phase-shifted-carrier or level-shifted-carrier pulse-width-modulation. The advantage of the proposed active voltage balancing method in comparison with other control techniques is its simplicity without requiring complex computations. Simulation results of the five-level SM converters are presented to verify the performance of proposed active voltage balancing method.
4‐Hydroxyderricin and xanthoangelol from Ashitaba (Angelica keiskei) suppress differentiation of preadiopocytes to adipocytes via AMPK and MAPK pathways (2013)

4HD and XAG inhibit adipocytes differentiation through AMPK and mitogen-activated protein kinase pathways, resulting in the down-expression of adipocyte-specific transcription factors.