gebhart/patrepeval huggingface dataset:
Wilms' Tumor 1 (WT1) as a Novel Molecular Target in Breast Cancer (2003)

Abstract : High levels of Wilms' Tumor 1 (W%T1) mRNA in breast tumors are linked with poor prognosis for breast cancer patients. However, the function of WT1 protein in breast cancer is not known. Recently we demonstrated that the HER2/neu oncogene, which is a well-known poor prognostic indicator for breast cancer patients, engages Akt to increase WT1 expression to stimulate G1 to S phase cell cycle progression and suppress apoptosis in breast cancer cells. Increased G1 to S phase cell cycle progression and decreased apoptosis are correlated with increased cyclin D1 and Bcl-2 levels. We have preliminary data indicating that Insulin-like Growth Factor-I also uses the Akt pathway to increase WT1 protein expression. We are currently investigating the role of WT1 in Insulin-like Growth Factor-I signaling. WT1 has been shown to undergo two splicing events, which result in four different isoforms. Our preliminary data indicate that all four WT1 isoforms enhance the proliferation of MCF-7 breast cancer cells, and reduce their sensitivity to tamoxifen. However, the WT1 isoforms do not appear to modulate the sensitivities of MCF-7 cells to doxorubicin and taxol. We plan to determine the mechanisms and the isoforms by which WT1 deregulates breast cancer cell proliferation and tamoxifen sensitivity.
<title>Interplanetary He II extreme-ultraviolet observation on PLANET-B</title> (1993)

Japan's spacecraft PLANET-B will be launched to Mars. An EUV measurement of 30.4 nm wavelength is proposed for an interplanetary He II observation during the cruising phase from the Earth to the Mars. This measurement will help our understanding of the creation and loss of interplanetary He II. Another objective is the imaging of the plasmasphere and magnetotail of the Earth. The EUV scanner we have designed for PLANET-B mission will provide the opportunity to observe both interplanetary and magnetospheric He II.
Preparation of DNA-carrying affinity latex and purification of transcription factors with the latex (1994)

We have developed DNA-carrying latex particles for the separation and purification of transcription factors. These particles consist of styrene (St), glycidyl methacrylate (GMA) and divinylbenzene (DVB). It was confirmed that the ethanolamine-treated surface of these particles suffered no nonspecific adsorption of proteins. To the latex particles sequence-specific DNA oligomers were immobilized via covalent coupling. A transcription factor, E4TF3, was efficiently purified to homogeneity using the latext particles. In contrast, the purification using DNA-carrying Sepharose gel yielded poor results. Compared to DNA-carrying Sepharose gel, the latex particles exhibited several times higher efficiency in the purification of E4TF3 from the crude nuclear extract.
Evaluation of the Measurement of Plasma Fructosamine Concentration in Aged Subjects. (1991)

Recently, plasma fructosamine concentration has been used as an indication of mean plasma glucose level preceding at last 1 to 2 weeks. In the present study, to characterize the clinical significance and problems of plasma fructosamine concentration in aged subjects (greater than or equal to 65 yrs), we determined plasma fructosamine concentration as well as serum albumin, total protein, HbA1, AbA1c and fasting plasma glucose concentrations in 81 (less than 65 yrs) non-diabetic subjects (group A), 161 aged (greater than or equal to 65 yrs) non-diabetic subjects and 26 aged diabetics (group D). Aged non-diabetic subjects were further classified into 75 subjects with good ADL (group B) and 86 with poor ADL (group C). The normal limit of plasma fructosamine concentration (mean +/- 2SD) in group A was 24% higher (3.1 mmol/l) than that in group B (2.5 mmol/l) but the plasma fructosamine/serum albumin ratio (F/ALB) was similar in these two groups. Plasma fructosamine correlated negatively (p less than 0.01) with age. This aging effect was explained by the reduced serum albumin in aged subjects. However, in group C, reduced plasma albumin was not associated with reduced plasma fructosamine. Plasma fructosamine corrected by albumin (F/ALB) is a useful parameter of blood glucose control in aged subjects. In aged subjects with poor ADL, HbA1, HbA1c and plasma glucose should be determined with fructosamine.
Drug-resistantEscherichia coli, Rural Idaho (2005)

Stool carriage of drug-resistant Escherichia coli in home-living residents of a rural community was examined. Carriage of nalidixic acid-resistant E. coli was associated with recent use of antimicrobial agents in the household. Household clustering of drug-resistant E. coli was observed. Most carriers of drug-resistant E. coli lacked conventional risk factors.
ACM-BCB 2018 Computational Advances in Molecular Epidemiology (CAME) Chairs' Welcome (2018)

No abstract available.
Gellan Gum: Fermentative Production, Downstream Processing and Applications (2007)

The microbial exopolysaccharides are water-soluble polymers secreted by microorganisms during fermentation.The biopolymer gellan gum is a relatively recent addition to the family of microbial polysaccharides that is gaining much importance in food, pharmaceutical and chemical industries due to its novel properties.It is commercially produced by C. P. Kelco in Japan and the USA.Further research and development in biopolymer technology is expected to expand its use.This article presents a critical review of the available information on the gellan gum synthesized by Sphingomonas paucimobilis with special emphasis on its fermentative production and downstream processing.Rheological behaviour of fermentation broth during fermentative production of gellan gum and problems associated with mass transfer have been addressed.Information on the biosynthetic pathway of gellan gum, enzymes and precursors involved in gellan gum production and application of metabolic engineering for enhancement of yield of gellan gum has been specified.Characteristics of gellan gum with respect to its structure, physicochemical properties, rheology of its solutions and gel formation behaviour are discussed.An attempt has also been made to review the current and potential applications of gellan gum in food, pharmaceutical and other industries.
Angular-dependent upper critical field of overdoped Ba(Fe1−xNix)2As2 (2013)

In-plane resistivity measurements as a function of temperature, magnetic field, and its orientation with respect to the crystallographic $ab$ plane were used to study the upper critical field, ${H}_{c2}$, of two overdoped compositions of the iron-based superconductor Ba(Fe${}_{1\ensuremath{-}x}$Ni${}_{x}$)${}_{2}$As${}_{2}$, $x=0.054$ and $x=0.072$. Measurements were performed using precise alignment (with accuracy less than 0.1${}^{\ensuremath{\circ}}$) of magnetic field with respect to the Fe-As plane. The dependence of the ${H}_{c2}$ on angle $\ensuremath{\theta}$ between the field and the $ab$ plane was measured in isothermal conditions in a broad temperature range. We found that the shape of ${H}_{c2}(\ensuremath{\theta})$ clearly deviates from the Ginzburg-Landau functional form.
New technology offers mining organisations hope for the future (2014)

Australia's mining industr y has reached a new five-year low, with analysts saying it will take years to recover. Research shows an over whelming 93 per cent of mining leaders are not optimistic about their growth prospects for the next 12 months, up by more than 50 per cent compared to last year (Mining Business Outlook, 2014). Organisations are struggling to secure capital, increase productivity and compete with overseas projects.
El aumento de la fragilidad con el tamaño en estructuras de hormigón (1998)

En este artículo se comentan dos métodos utilizados para modelizar el proceso de fractura del hormigón; el modelo de la fisura cohesiva y el de la fisura equivalente. A partir de estos modelos se puede predecir cuantitativamente el aumento de la fragilidad de un elemento estructural al aumentar su tamaño, fenómeno conocido como efecto del tamaño. En la segunda parte se muestran dos aplicaciones de la Mecánica de la Fractura al hormigón; una para el hormigón en masa y otra para vigas débilmente armadas.
Spin battery operated by ferromagnetic resonance (2002)

Precessing ferromagnets are predicted to inject a spin current into adjacent conductors via Ohmic contacts, irrespective of a conductance mismatch with, for example, doped semiconductors. This opens the way to create a pure spin source (``spin battery'') by the ferromagnetic resonance. We estimate the spin current and spin bias for different material combinations.
A Novel Control Method and Application of DC-link Voltage Control Method (2013)

This paper presents a novel DC-link voltage integrated control method of distribution static compensator (D-STATCOM),it combines the nonlinear control and fuzzy predictive control of organic,which draws on steady-state load control accuracy and transient load fuzzy predictive control,predictive adaptive.Fuzzy predictive control automatically real-time correcs fuzzy rules to meet the need of dynamic compensation by adaptive factor.Simulation analysis and field practice show,integrated control than conventional PID control has better robustness,effectively restrains voltage overshoot and current inrush,raises D-STATCOM to compensate reactive power,three-phase unbalance and harmonic suppression effect,shows good dynamic and practical.
Treatment outcome of an unselected cohort of tuberculosis patients in relation to human immunodeficiency virus serostatus in Zomba hospital, Malawi (1998)

There is little information about treatment outcome in patients with smear-negative pulmonary tuberculosis (PTB) or extrapulmonary tuberculosis (EPTB) treated under routine programme conditions in subsaharan Africa. A prospective study was carried out to determine treatment outcome in an unselected cohort of TB patients admitted to Zomba General Hospital, Malawi. Eight hundred and twenty-seven adult TB patients (451 men and 376 women) were registered between 1 July and 31 December 1995. Standardized treatment outcomes of treatment completion, death, default, and transfer to another district were assessed in relation to type of TB, human immunodeficiency virus (HIV) serostatus, age and gender. Two hundred and fifty-four patients (31%) died by the end of treatment, half of the deaths occurring in the first month. Death rates were 19% among 386 patients with smear-positive PTB, 46% among 211 patients with smear-negative PTB, and 37% among 230 patients with EPTB; 77% of the patients were HIV seropositive. Among new patients, HIV-positive patients had higher death rates than HIV-negative patients (hazard ratio [HR] 2.5; 95% confidence interval [95% CI] 1.6-3.8). Smear-negative patients had the highest death rates (HR 3.9; 95% CI 2.7-5.5 compared to smear-positive patients), followed by EPTB patients (HR 2.6, 95% CI 1.8-3.7 compared to smear-positive patients). Death rates increased with age but were similar in men and women. Adult patients in Malawi with smear-negative PTB and EPTB have low treatment completion and high death rates, related to high levels of HIV infection. National TB control programmes in areas of high HIV prevalence should no longer ignore treatment outcomes in patients with smear-negative PTB or EPTB.
Integrating Human and Rodent Data to Identify the Genetic Factors Involved in Chronic Kidney Disease (2010)

The increasing numbers of patients with chronic kidney disease combined with no satisfying interventions for preventing or curing the disease emphasize the need to better understand the genes involved in the initiation and progression of complex renal diseases, their interactions with other host genes, and the environment. Linkage and association studies in human, rat, and mouse have been successful in identifying genetic loci for various disease-related phenotypes but have thus far not been very successful identifying underlying genes. The purpose of this review is to summarize the progress in human, rat, and mouse genetic studies to show the concordance between the loci among the different species. The collective utilization of human and nonhuman mammalian datasets and resources can lead to a more rapid narrowing of disease loci and the subsequent identification of candidate genes. In addition, genes identified through these methods can be further characterized and investigated for interactions using animal models, which is not possible in humans.
Preliminary study on efficiency of transverse and extensional power harvesting on a vibrating plate (2007)

Power harvesting systems generate electric power\nfrom mechanical vibration using electromechanical\ntransducers. To assess the practical performance of\nthese systems, it is important to be able to estimate\nthe maximum power that could be harvested from a\nspecific structure and to derive the optimal conditions\nfor such harvesting. Dampers have been used to\nrepresent idealised power harvester devices, assuming\nthat a fixed proportion of the power dissipated in the\nabsorber could be scavenged. Such idealised power\nabsorbers have been applied to a vibrating plate in\ntwo different configurations: a configuration that\nscavenges power from the transverse displacement\nand one that gather power from the extensional\ndisplacement at the plate surface. The maximum\npower obtainable from such structure has been\ncalculated for tonal excitation of the structure. The\nattenuation of the kinetic energy, due to the application\nof the absorber to the structure, has also been studied\nin order to find analogies between power harvesting\nand shunt damping.
Activation of NF-κB/p65 Facilitates Early Chondrogenic Differentiation during Endochondral Ossification (2012)

The presented data demonstrate that NF-κB/p65 signaling, as well as its intensity and timing, represents one of the transcriptional regulatory mechanisms of the chondrogenic developmental program of chondroprogenitor cells during endochondral ossification. Importantly, these results provide novel possibilities to improve the success of cartilage and bone regenerative techniques.
Women only? an Exploration of the Place of Men within Nursing (2004)

&lt;p&gt;&lt;b&gt;This dissertation came out of my wondering why there are still so few men going into nursing especially when one considers that the history of nursing reveals men have been a part of nursing for a long time. In New Zealand it is only since the mid seventies that men have been able to gain the exact same nursing qualifications as their women colleagues.&lt;/b&gt;&lt;/p&gt; &lt;p&gt;Men in nursing are still seen as unusual in that they work in a predominantly female occupation and have had their masculinity questioned by the myth that all men in nursing must be gay. There is also the notion that caring is a difficult task for men and is seen by society as a uniquely feminine ability. Both issues are related to dominant notions of masculinity. In addition to this there is currently a crisis in terms of a nursing shortage and it has been suggested that one way to resolve this crisis is to encourage more men into nursing. Thus this exploration as to why there are so few men in nursing is timely.&lt;/p&gt; &lt;p&gt;Men who choose nursing as a career risk challenging the traditional roles of their gender stereotype. A comprehensive search of the literature from different disciplines reveals deeper issues than just the commonly held assumption that nursing is not masculine. Exploring the issues of gender with a particular focus on masculinity has uncovered the concept of hegemonic masculinity. This describes how gender is practiced in a way that legitimises patriarchy, reinforcing the dominant position of men overiwomen as well as over other groups of men. It is these patriarchal attitudes that have seen men marginalised within nursing. On the one hand men in nursing could be seen as challenging the current dominant masculine ideal. However, on the other hand men in nursing may not challenge this hegemonic masculinity; instead often supporting the status quo in an effort to maintain their own masculinity.&lt;/p&gt; &lt;p&gt;The implication for nursing, if it is to increase the numbers of men in the profession, is to challenge this notion of hegemonic masculinity. This needs to be done appropriately by critically examining this concept rather than by merely replacing one hegemony with another. A greater awareness of how hegemonic masculinity and notions of gender have historically affected, and continue to affect the development of nursing is important. However, issues of gender and masculinity have often been overlooked in nursing education. It is now time for nursing education to include a critical exploration of gender issues and how it relates to men as part of undergraduate nursing education for both men and women students.&lt;/p&gt;
A comparative study of a low doppler shift in a carrier tracking loop for GPS (2012)

This paper compares a carrier tracking scenario when a received Global Positioning System (GPS) signal has low Doppler frequency. It is shown that if the Numerically Controlled Oscillator (NCO) is quantized to 1 bit, the carrier tracking loop is unable to keep track of the incoming signal which leaves the tracking loop oscillating between the upper and lower bounds of the tracking loop bandwidth. One way of overcoming this problem is presented and compared with another existing solution, found in the literature, providing comparative results from the use of real-recorded off the air GPS L1 signals. Results show that the proposed method performs better tracking performance compared with the existing solution which it requires much less hardware complexity.
Novel holographic shearing interferometer for measuring lens lateral aberration (1992)

A new type of holographic shearing interferometer for measuring lens lateral aberrations is described. In this interferometer a vertical tilt is introduced between the output beams so that the output fringes directly map out the lateral aberration curve of the lens being tested. In addition to this we improve the precision of the interferometer by making it a multiple-beam system through the use of multiple-exposure holograms. The theory of operation of the interferometer is described, and results obtained with an experimental system are presented.
The Inhibitory Action of Kohamaic Acid A Derivatives on Mammalian DNA Polymerase β (2008)

We previously isolated a novel natural product, designated kohamaic acid A (KA-A, compound 1), as an inhibitor of the first cleavage of fertilized sea urchin eggs, and found that this compound could selectively inhibit the activities of mammalian DNA polymerases (pols). In this paper, we investigated the structure and bioactivity of KA-A and its chemically synthesized 11 derivatives (i.e., compounds 2-12), including KA-A - fatty acid conjugates. The pol inhibitory activity of compound 11 [(1S*,4aS*,8aS*)-17-(1,4,4a,5,6,7,8,8a-octahydro-2,5,5,8a-tetramethyl-naphthalen-1-yl)heptadecanoic acid] was the strongest among the synthesized compounds, and the range of IC(50) values for mammalian pols was 3.22 to 8.76 microM; therefore, the length of the fatty acid side chain group of KA-A is important for pol inhibition. KA-A derivatives could prevent human cancer cell (promyelocytic leukemia cell line, HL-60) growth with the same tendency as the inhibition of mammalian pols. Since pol beta is the smallest molecule, we used it to analyze the biochemical relationship with KA-A derivatives. From computer modeling analysis (i.e., docking simulation analysis), these compounds bound selectively to four amino acid residues (Leu11, Lys35, His51 and Thr79) of the N-terminal 8-kDa domain of pol beta, and the binding energy between compound 11 and pol beta was largest in the synthesized compounds. The relationship between the three-dimensional molecular structures of KA-A-related compounds and these inhibitory activities is discussed.
Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies (2015)

Butterflies are exceptionally diverse but their potential as an experimental system has been limited by the difficulty of deciphering heterozygous genomes and a lack of genetic manipulation technology. Here we use a hybrid assembly approach to construct high-quality reference genomes for Papilio xuthus (contig and scaffold N50: 492 kb, 3.4 Mb) and Papilio machaon (contig and scaffold N50: 81 kb, 1.15 Mb), highly heterozygous species that differ in host plant affiliations, and adult and larval colour patterns. Integrating comparative genomics and analyses of gene expression yields multiple insights into butterfly evolution, including potential roles of specific genes in recent diversification. To functionally test gene function, we develop an efficient (up to 92.5%) CRISPR/Cas9 gene editing method that yields obvious phenotypes with three genes, Abdominal-B, ebony and frizzled. Our results provide valuable genomic and technological resources for butterflies and unlock their potential as a genetic model system.
New Educational Materials for Attracting High School Students to Engineering (2020)

The purpose of this paper is to call for cooperation in a project started by the Kyushu Society for Engineering Education to recruit active students to engineering fields. The project aims to build a collection of educational materials that helps motivate students to study in high school by understanding how basic mathematics and sciences are important in engineering and technologies. The concept and examples of the materials are presented.
Hybrid Hairy Janus Particles as Building Blocks for Antibiofouling Surfaces (2016)

Herein, we report a new strategy for the design of antifouling surfaces by using hybrid hairy Janus particles. The amphiphilic Janus particles possess either a spherical or a plateletlike shape and have core-shell structures with an inorganic core and hydrophilic/hydrophobic polymeric shells. Subsequently, these bifunctional Janus particles enable the fabrication of surfaces with modularity in chemical composition and final surface topography, which possess antifouling properties. The antifouling and fouling-release capability of the composite Janus particle-based surfaces is investigated using the marine biofilm-forming bacteria Cobetia marina. The Janus particle-based coatings are robust and significantly reduce bacterial retention under both static and dynamic conditions independent of the particle geometry. The plateletlike (kaolinite-based) Janus particles represent a scalable system for the rational design of antifouling coatings as well as their large-scale production and application in the future.
High-energy-density composite flywheel (1980)

A flywheel has been designed and fabricated to demonstrate a high energy density of 36 w-h/lb (80 w-h/kg) in the rotor. The rotor design consists of a multiring, subcircular rim made of S-glass/epoxy composite and Kevlar/epoxy composite materials and mounted on a spoked hub made of graphite/epoxy composite materials. Two flywheel rotors are available for test.