gebhart/patrepeval huggingface dataset:
Isolation and Characterization of a Family of Stable RNA Tetraloops with the Motif YNMG That Participate in Tertiary Interactions (2002)

RNA is known to fold into a variety of structural elements, many of which have sufficient sequence complexity to make the thermodynamic study of each possible variant impractical. We previously reported a method for isolating stable and unstable RNA sequences from combinatorial libraries using temperature gradient gel electrophoresis (TGGE). This method was used herein to analyze a six-nucleotide RNA hairpin loop library. Three rounds of in vitro selection were performed using TGGE, and unusually stable RNAs were identified by cloning and sequencing. Known stable tetraloops were found, including sequences belonging to the UNCG motif closed by a CG base pair, and the CUUG motif closed by a GC base pair. In addition, unknown tetraloops were found that were nearly as stable as cUNCGg, including sequences related through substitution of the U with a C (Y), the C with an A (M), or both. These substitutions allow hydrogen bonding and stacking interactions in the UNCG loop to be maintained. Thermodynamic analysis of YNMG and variant loops confirmed optimal stability with Y at position 1 and M at position 3. Similarity in structure and stability among YNMG loops was further supported by deoxyribose substitution, CD, and NMR experiments. A conserved tertiary interaction in 16S rRNA exists between a YAMG loop at position 343 and two adenines in the loop at position 159 (Escherichia coli numbering). NMR and functional group substitution experiments suggest that YNAG loops in particular have enhanced flexibility, which allows the tertiary interaction to be maintained with diverse loop sequences at position 159. Taken together, these results support the existence of an extended family of UNCG-like tetraloops with the motif cYNMGg that are thermodynamically stable and structurally similar and can engage in tertiary interactions in large RNA molecules.
Central neurocytomas are genetically distinct from oligodendrogliomas and neuroblastomas (2000)

Central neurocytomas are genetically distinct from oligodendrogliomas, and chromosomes 1p and 19q probably do not play an important role in their pathogenesis. N-myc and EGFR amplification are rare.
Physical Behavior in Older Persons during Daily Life: Insights from Instrumented Shoes (2016)

Activity level and gait parameters during daily life are important indicators for clinicians because they can provide critical insights into modifications of mobility and function over time. Wearable activity monitoring has been gaining momentum in daily life health assessment. Consequently, this study seeks to validate an algorithm for the classification of daily life activities and to provide a detailed gait analysis in older adults. A system consisting of an inertial sensor combined with a pressure sensing insole has been developed. Using an algorithm that we previously validated during a semi structured protocol, activities in 10 healthy elderly participants were recorded and compared to a wearable reference system over a 4 h recording period at home. Detailed gait parameters were calculated from inertial sensors. Dynamics of physical behavior were characterized using barcodes that express the measure of behavioral complexity. Activity classification based on the algorithm led to a 93% accuracy in classifying basic activities of daily life, i.e., sitting, standing, and walking. Gait analysis emphasizes the importance of metrics such as foot clearance in daily life assessment. Results also underline that measures of physical behavior and gait performance are complementary, especially since gait parameters were not correlated to complexity. Participants gave positive feedback regarding the use of the instrumented shoes. These results extend previous observations in showing the concurrent validity of the instrumented shoes compared to a body-worn reference system for daily-life physical behavior monitoring in older adults.
Proteomics of Human Milk (2008)

Both expression and functional proteomics have been applied to identifying and characterizing human milk proteins. The most extensive expression work, resulting in more than 107 identified proteins reported in an annotated database, was done on the proteins associated with the milk fat globule membranes of human colostrum. Reports on the differences in protein expression between colostrum and mature milk and on the relationship between the mother’s diet and protein milk composition may be regarded as functional proteomics studies. Future studies of the human milk proteome will be beneficial for both lactating mothers and nursing children.
Photodynamics and ground state librational states of ClF molecule in solid Ar. Comparison of experiment and theory (2004)

Photodynamics calculations of a ClF molecule in solid Ar are compared to experimental results and a new interpretation is given for the observed femtosecond-pump–probe signal modulation. We analyze the round-trip and depolarization times for the excited state wave-packet motion and discuss the incorporation of lattice cage motions that partially explain the time dependence of the measured signal. Librational eigenstates and eigenenergies are calculated by solving the rotational Schrödinger equation in the previously computed [T. Kiljunen, M. Bargheer, M. Gühr and N. Schwentner, Phys. Chem. Chem. Phys., 2004, 6, 2185–2197] octahedral potentials that hinder free molecular rotation in the solids. The obtained level structure is compared to infrared-spectroscopic results. We comment on the correspondence between temperature effects in the classical dynamics of the nuclei and the quantum mechanical probability distributions. We find the combinative treatment of different simulation temperatures congruous for interpreting the experimental results at cryogenic conditions.
Integrating Art Therapy Methodology in Brief Inpatient Substance Abuse Treatment for Adults (2002)

ABSTRACT Decades of drug addiction research and clinical work have underscored the need for multifaceted and comprehensive treatment responses in order to sufficiently address the varied needs of individuals struggling with addiction. One valuable treatment component that can be incorporated into traditional treatment protocols to expand the comprehensive nature of treatment response is art therapy. A conceptual framework is presented, detailing the integrative opportunities and benefits of including an art therapy component to short-term hospital-based inpatient substance abuse treatment programs. A creative arts component can be particularly beneficial for brief inpatient programs, where the client population is diverse, in crisis, and at high-risk for relapse; and where clinicians need to obtain comprehensive client information from multiple sources in a short amount of time. Art therapy methodology can provide a mechanism for collecting such collateral information for assessment purposes, can be employed to facilitate therapeutic change, and is used to track and document client progress and clinical change over time. Practice guidelines and specific treatment techniques are presented through short case examples.
Verhalten des spezifischen Knochenresorptionsparameters TRAP 5b bei Patienten nach endoprothetischem Hüftgelenkersatz (2003)

Fragestellung: Implantatlockerungen werden häufig erst spät mit dem Auftreten von osteolytischen Destruktionen im Bereich des Prothesenlagers erkannt. Ein Knochenstoffwechselparameter, der bei noch unauffälligem Röntgenbefund eine Lockerung mit ausreichender Sicherheit festzustellen könnte, würde entscheidende Vorteile bringen. Die BoneTRAP wird ausschließlich von resorbierenden Osteoklasten sezerniert. In der hier vorgestellten Untersuchung soll die Wertigkeit der BoneTRAP in Bezug auf lokale periprothetische Knochenveränderungen überprüft werden.
Low-Rank Embedded Ensemble Semantic Dictionary for Zero-Shot Learning (2017)

Zero-shot learning for visual recognition has received much interest in the most recent years. However, the semantic gap across visual features and their underlying semantics is still the biggest obstacle in zero-shot learning. To fight off this hurdle, we propose an effective Low-rank Embedded Semantic Dictionary learning (LESD) through ensemble strategy. Specifically, we formulate a novel framework to jointly seek a low-rank embedding and semantic dictionary to link visual features with their semantic representations, which manages to capture shared features across different observed classes. Moreover, ensemble strategy is adopted to learn multiple semantic dictionaries to constitute the latent basis for the unseen classes. Consequently, our model could extract a variety of visual characteristics within objects, which can be well generalized to unknown categories. Extensive experiments on several zero-shot benchmarks verify that the proposed model can outperform the state-of-the-art approaches.
Predicted MIMO performance in intra-vehicle channels (2008)

Intra-vehicle channels experience moderate to extreme multipath fading, which is best modeled by the hyper-Rayleigh channel. Using this model, MIMO transmission was simulated over the ranges of K values that were measured in vehicles, from 8 dB to -150 dB. MIMO simulations resulted in consistent channel capacity regardless of varying K values, which predicts that MIMO provides consistent channel behavior over the wide range of fading experienced in vehicles, potentially allowing for robust and reliable intra-vehicle communication.
Fluoxetine Treatment Seems to Reduce the Beneficial Effects of Cognitive‐Behavioral Therapy in Type B Alcoholics (1996)

Alcoholic subtypes identified by cluster analysis seem to be differentially responsive to the effects of fluoxetine treatment on drinking-related outcomes. Serotonergic abnormalities previously identified among a subgroup of alcoholics who are also characterized by impulsivity and severity of alcohol dependence may help to explain the differential medication effect. Based on these findings, it is recommended that, in the absence of a comorbid mood or anxiety disorder, fluoxetine not be used to maintain abstinence or reduce drinking in high-risk/severity alcoholics.
NOV-002, a chemoprotectant/immunomodulator, added to first-line carboplatin/paclitaxel in advanced non-small cell lung cancer (NSCLC): A randomized Phase 1/2, open-label, controlled study (2006)

17021 Background: NOV-002 is a proprietary formulation of oxidized glutathione that modulates production of cytokines and hematopoietic growth factors. A randomized, multi-site advanced NSCLC trial conducted in the Russian Federation showed a one-year survival rate of 63% with NOV-002 + cytotoxic chemotherapy compared to 17% with cytotoxic chemotherapy alone. Methods: Forty-four chemotherapy-naïve, Stage IIIB/IV NSCLC patients (ECOG 0–2, stratified by disease stage) were randomized to one of three groups for six months of treatment: Groups A and B: NOV-002 in combination with carboplatin and paclitaxel (C+P). For each nominal 21-day chemotherapy cycle, these groups received 60 mg of NOV-002 i.v. daily for the first 4 days, then 60 mg i.m. (A) or s.c. (B) weekdays for the next 17 days. Group C: C+P alone. Initial doses of C and P in all three groups were 225 mg/m 2 and AUC 6, respectively. Initiation of repeat C+P cycles required an absence of hematologic and other toxicities in excess of pre-defined values. Primary study endpoints included tumor response (scans performed at baseline and then every two months) and safety. Results: An intent-to-treat analysis of the best overall objective tumor response (WHO criteria), showed that 11 out of 16 (69%) Group B patients demonstrated greater than 50% tumor shrinkage versus 5 out of 15 (33%) in the control group (C) (p = 0.044, logistic regression stratified on disease stage). Six out of 13 (46%) patients in Group A demonstrated an objective response. 100% of NOV-002 treated patients in Group B and 85% in Group A were able to complete four cycles of C+P compared to 50% of control patients (Group C) (p = 0.004, chi square). NOV-002 was well-tolerated in this patient population. Conclusions: These data continue to suggest increased efficacy of NOV-002 plus cytotoxic chemotherapy compared to chemotherapy alone in advanced NSCLC. [Table: see text]
Real time analysis of ultra-thin CIGS thin film deposition (2012)

Thin films of Cu(In,Ga)Se <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> with various copper contents as functions of the copper and gallium contents were deposited by co-evaporation onto thermally oxidized silicon wafer (100). In-situ Real Time Spectroscopic Ellipsometry (RTSE) is used to understand the effect of the Ga/(In+Ga) ratio and the Cu atomic % on the growth and optical properties of ultra -thin CIGS films. We have demonstrated that RTSE can be used effectively to identify the growth process and to distinguish the effects of copper from those of gallium on the surface roughness evolution and dielectric functions.
Highway Routine Maintenance Programming at Network Level (1988)

This paper describes a mathematical programming procedure for routine maintenance activities at the network level developed for incorporation into the existing pavement maintenance‐management system of Indiana. The procedure allows a highway agency to determine amounts of different routine maintenance activity types to be performed over a given time period under the constraints of production requirements, budget allocation, manpower, material and equipment availability, and pavement rehabilitation schedule. A priority‐weighting factor is assigned to each maintenance work so that higher‐priority work would be selected for execution. Rehabilitation constraints are included to ensure proper coordination between the selected routine maintenance activities and planned rehabilitation projects. An integer programming optimization model is developed for the proposed procedure. The types of data required and their acquisition are discussed. A numerical example based upon routine maintenance information obtained from the Indiana Department of Highways is presented as an illustration.
A Virtual-Channel Free Mapping for Application-Specific On-Chip Torus Networks. (2006)

Various types of Networks-on-Chips (NoCs) have been employed light-weight routers compared with those in parallel computers, and a virtual-channel mechanism, which requires additional logic and pipeline stages, is one of the crucial factors for a low cost implementation of an NoC router in the case of simple tile-based architectures. Although a torus network, which exploits wrap-around channels, achieves higher throughput and lower latency than a same-sized mesh, a virtual-channel mechanism is usually required to avoid deadlocks in tori with dimension-order routing. In this paper, we propose a scheme to remove virtual channels in tori by accomplishing the following steps: 1) providing a mechanism which allows wraparound channels to be individually disabled in each router, 2) a task mapping strategy that carefully assigns tasks to a tori, so that as many wrap-around channels as possible are exploited without introducing deadlocks or performance degradation. Additionally, we extend this strategy to avoid deadlocks when application traffic patterns are unknown or incompletely analyzed. Although the proposed mapping does not use virtual channels, it achieves almost the same performance as conventional mapping in tori in ten traces. Moreover, the hardware amount of the proposed router can be decreased to 52.4 % of a conventional router providing two virtual channels for tori. 1
High-Temperature Cycling of the 2.5 V Cell consisting of LAMO and LTO for 12 V Battery - Invited Talk (2008)

Abstract not Available.
Titelbild: Architecture and Evolution of Organic Chemistry (Angew. Chem. 44/2005) (2005)

Organische Reaktionen werden als verknüpfte Netzwerke behandelt, um so den Mechanismus zu untersuchen, nach dem sich die organische Chemie entwickelte. In ihrer Zuschrift auf S. 7429 ff. analysieren Grzybowski et al. organische Synthesen, die zwischen 1850 und 2000 beschrieben wurden, enthüllen so die Architektur und Entwicklung der Synthese von Molekülen und diskutieren die Anwendung dieser Technik in der chemischen Industrie. Das Titelbild zeigt einen typischen “Knoten” in einem Netzwerk der organischen Chemie.
Selective intrauterine growth restriction (SIUGR) type II: proposed subclassification to guide surgical management (2020)

Over one-third of SIUGR type II patients experienced dual survival after treatment with laser surgery. Normal MCA psv and normal DV waveforms were associated with SIUGR type II survival of the SIUGR twin. <i>Post hoc</i> exploration and subclassification of SIUGR type II patients by preoperative Doppler indices created two groups, one (type IIa) with 50% survival and one (type IIb) with 0% survival of the SIUGR twin after laser surgery. Upon further confirmation, these findings may provide guidance for counseling patients and conducting fetal therapy.
Development and validation of quick Acute Kidney Injury-score (q-AKI) to predict acute kidney injury at admission to a multidisciplinary intensive care unit (2019)

AKI is associated with increased risk of death, prolonged length of stay and development of de-novo chronic kidney disease. The aim of our study is the development and validation of prediction models to identify the risk of AKI in ICU patients up to 7 days. We retrospectively recruited 692 consecutive patients admitted to the ICU at San Bortolo Hospital (Vicenza, Italy) from 1 June 2016 to 31 March 2017: 455 patients were treated as the derivation group and 237 as the validation group. Candidate variables were selected based on a literature review and expert opinion. Admission eGFR< 90 ml/min /1.73 mq (OR 2.78; 95% CI 1.78-4.35; p<0.001); SOFAcv 2 (OR 2.23; 95% CI 1.48-3.37; p<0.001); lactate 2 mmol/L (OR 1.81; 95% CI 1.19-2.74; p = 0.005) and (TIMP-2)(IGFBP7) 0.3 (OR 1.65; 95% CI 1.08-2.52; p = 0.019) were significantly associated with AKI. For the q-AKI score, we stratified patients into different AKI Risk score levels: 0-2; 3-4; 5-6; 7-8 and 9-10. In both cohorts, we observed that the proportion of AKI patients was higher in the higher score levels.
Precipitação de fase de laves no aço inoxidável superferrítico 28%Cr-4%Ni-2%Mo-Nb. (2006)

\n Estudos anteriores de precipitação, em outros aços superferríticos, constataram a ocorrência de precipitação das fases sigma, qui, de Laves e até de austenita, que no posterior resfriamento pode se transformar em martensita. O objetivo principal do presente trabalho foi estudar a precipitação de fases de Laves no aço inoxidável superferrítico X 1 CrNiMoNb 28 4 2 (Werkstoff-Nr. 1.4575). Para isto foram utilizadas algumas técnicas complementares de análise microestrutural, tais como microscopia óptica, eletrônica de varredura (MEV) e eletrônica de transmissão (MET). A composição química das fases foi estudada por análise de raios X por dispersão de energia tanto no MEV como no MET. A estrutura cristalina das fases foi estudada por difração de elétrons em área selecionada no MET. A fase que se precipita em maior quantidade no aço 1.4575 é a fase sigma. No entanto, também foram identificadas de maneira inequívoca, nos contornos de grãos, após envelhecimento a 850 ºC, pequenas quantidades de fase de Laves do tipo MgZn2, com estrutura hexagonal compacta e composição química (Fe,Cr,Ni)2(Nb,Mo,Si). O crescimento da fase de Laves é inibido pelo envolvimento da fase sigma, que também precipita nos contornos de grãos, mas em maior quantidade. Não foram detectadas as presenças das fases qui e austenita na temperatura estudada.\n
Association Between the Timing of Goals-of-Care Discussion and Hospitalization Outcomes in Patients With Metastatic Cancer (2019)

Among hospitalized patients with stage IV cancer, performing an early GOC discussion has an important association with lower hospital readmission rates and increased rates of goal-congruent patient care.
New routes to 1‐functionally substituted arylbenzotriazoles: 3‐Benzotriazol‐1‐yl‐pyridazine‐4‐ones, 5‐benzotriazol‐1‐yl‐pyridazine‐6‐ones and 5‐benzotriazol‐1‐yl‐pyridazine‐6‐imines (2000)

Abstract Condensation of 1‐arylhydrazono‐1‐benzotriazol‐1‐yl 2‐propanones ( 5a‐c ) with DMF DMA afforded 1‐aryl‐3‐benzotriazol‐1‐yl‐1,4‐dihydropyridazine‐4‐ones ( 8a‐c ). While condensation of 1‐functionally substituted methylbenzotriazoles 3b,c with 2‐arylhydrazono‐3‐oxoarylpropanal 13a,b give 3‐aroyl‐5‐(benzo‐triazolyl‐1‐yl)‐1,6‐dihydro‐1‐phenylpyridazine‐6‐ones and 6‐imines 14a‐d.
Comprehensive Aquatic Therapy (1997)

1. Aquatic Rehabilitation: A Historical Perspective 2. The Biophysiology of Aquatic Therapy 3. Facility Design and Water Management 4. Halliwick and Bad Ragaz Techniques 5. Watsu and Related Tecniques Uses and Modifications of Watsu in Rehabilitation 6. Aquatic Therapy Tools, Toys and Equipment 7. Aqua-Running: Applications and Technique 8. Aquatic Rehabilitation for Neurologic Disorders 9. Spine Pain: Aquatic Rehabilitation 10. Aquatic Therapy in Rheumatologic Disease 11. Aquatic Strategies in Musculoskeletal Pain 12. Pediatric Aquatic Therapy 13. Community Transitioning in Aquatic Therapy 14. Burn and Wound Therapy 15. Staff Training in Aquatic Therapy 16. Interdisciplinary Models of Care 17. Legal Aspects of Aquatic Therapy
Bit-serial pipeline synthesis and layout for large-scale configurable systems (2002)

In this paper, we present our datapath synthesis and layout tools which are targeted toward large-scale configurable systems with the logic capacity of up to millions of gates which consists of an easy design entry using C++, customized bit-serial circuit library for SRAM-based FPGAs, bit-serial pipeline circuit generator, and a circuit partitioner.
Hydrophobic microphase formation in surfactant solutions containing an amphiphilic graft copolymer (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHydrophobic microphase formation in surfactant solutions containing an amphiphilic graft copolymerAbdulkadir J. Dualeh and Carol A. SteinerCite this: Macromolecules 1990, 23, 1, 251–255Publication Date (Print):January 1, 1990Publication History Published online1 May 2002Published inissue 1 January 1990https://pubs.acs.org/doi/10.1021/ma00203a043https://doi.org/10.1021/ma00203a043research-articleACS PublicationsRequest reuse permissionsArticle Views321Altmetric-Citations93LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts