gebhart/patrepeval huggingface dataset:
Ocular Surface Reconstruction with the Autologous Conjunctival Epithelium and Establishment of a Feeder-Free and Serum-Free Culture System (2018)

Transplantation of the autologous cultured corneal limbal epithelium and oral mucosal epithelium is a standard technique for ocular surface reconstruction under corneal limbal stem cell deficiency. As an option for bilateral cases, we recommend utilization of autologous conjunctivae for ocular surface reconstruction. Autologous conjunctival epithelium sheet transplantation was effective for bilateral corneal limbal stem cell deficiency without symblepharon or severe keratinization. Moreover, we established a feeder-free and serum-free culture system of the limbal epithelium. This system can be applied for culturing conjunctival epithelia. Autologous cultured conjunctival epithelium transplantation is a practical option for treating bilateral corneal limbal stem cell deficiency.
Correction to Integrated Circuits and Logic Operations Based on Single-Layer MoS2 (2013)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to Integrated Circuits and Logic Operations Based on Single-Layer MoS2Branimir Radisavljevic, Michael B. Whitwick, and Andras Kis*View Author Information Electrical Engineering Institute, Ecole Polytechnique Federale de Lausanne (EPFL), CH-1015 Lausanne, SwitzerlandCite this: ACS Nano 2013, 7, 4, 3729Publication Date (Web):March 6, 2013Publication History Published online6 March 2013Published inissue 23 April 2013https://pubs.acs.org/doi/10.1021/nn400553ghttps://doi.org/10.1021/nn400553gcorrectionACS PublicationsCopyright © 2013 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views2552Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (53 KB) Get e-AlertscloseSUBJECTS:Circuits,Contact resistance,Insulators,Transistors Get e-Alerts
MIMO SAR imaging: Potential and challenges (2013)

This paper investigated MIMO SAR for several specific remote sensing applications from a top-level system description, with an aim to call for more publications and research on these topics. Due to the significantly increased degrees of freedom, MIMO SAR provides better system design flexibility and improved system performance. The potentials and challenges of MIMO SAR in HRWS remote sensing, GMTI, and 3D imaging are analyzed. It is shown that MIMO SAR indeed provides promising potentials for future remote sensing but much further research work about waveform diversity design and signal processing algorithm should be carried out.
Synthesis and Characterization of Rigid Rod Poly(p-phenylenes) (1996)

The polymer PP, which consists of a poly(p-phenylene) backbone with sulfonate ester and dodecyl side groups, is synthesized by a Pd-catalyzed coupling of the 1,3-propanediol diester of 2-dodecyl-5-methyl-1,4-benzenediboronic acid with 2,2‘-bis(3,5-di-tert-butylbenzenesulfonato)-4,4‘-dibromobiphenyl. Polymers with various molar masses are obtained, which are soluble without aggregation in conventional organic solvents. The good solubility of this rodlike polymer allows the accurate determination of the molar mass by light scattering, osmometry, and SEC with universal calibration. The dependence of the intrinsic viscosity [η] on the molar mass is determined from both the Mark−Houwink−Sakurada equation and the wormlike chain model. The low value of the persistence length (13 nm) indicates that these polymers are relatively flexible. It is shown that an approximate value of the persistence length, together with the parameters of the Mark−Houwink−Sakurada equation and the wormlike chain model, can be determined using only a single polydisperse sample.
Resting State and Kinetic Studies on the Asymmetric Allylic Substitutions Catalyzed by Iridium−Phosphoramidite Complexes (2007)

The resting state of the iridium catalyst in the asymmetric allylation of amines and kinetic data on the overall catalytic cycle are reported. The resting state is a complex of the metallacyclic catalyst with the olefinic unit of the allylamine product. The species containing the branched allylamine N-phenyl-1-phenylprop-2-enylamine and a related ethylene complex have been isolated in pure form. Binding constants of enantiomeric allylamines to the Ir(I) fragment were measured. The ratio of binding affinities is within experimental error of the ratio of rates for formation of the two enantiomeric amine products in the catalytic cycle. The rates of the catalytic reaction are first-order in allylic carbonate, amine, and catalyst and inverse-first order in product. This combination of data, along with the observation that the resting state is stable toward 1.5 equiv of allylic carbonate, implies that the reaction of the iridium(I) species with the allylic carbonate is reversible and endergonic, and that the allyl intermediate reacts with the nucleophile to form product. Finally, the simple synthesis of the metallacyclic iridium ethylene complex gives rise to a single-component, highly active, and enantioselective catalyst for the allylic amination.
Topical Treatment of Mild to Moderate Psoriasis (2010)

Topical therapies are used by most psoriasis patients either alone or in combination with systemic therapies and phototherapy. The objective of this paper is to review the different topical therapies to treat mild to moderate psoriasis, including corticosteroids, vitamin D analogs, tazarotene, topical calcineurin inhibitors, anthralin, salicylic acid, and coal tar and assess their effectiveness and tolerability. Topical therapies are important for treating psoriasis and will continue to play a major role even as new systemic therapies emerge.
A COMPARISON OF TWO STRATEGIES FOR AVOIDING NEGATIVE TRANSFER IN DOMAIN ADAPTATION BASED ON LOGISTIC REGRESSION (2018)

Abstract. In this paper we deal with the problem of measuring the similarity between training and tests datasets in the context of transfer learning (TL) for image classification. TL tries to transfer knowledge from a source domain, where labelled training samples are abundant but the data may follow a different distribution, to a target domain, where labelled training samples are scarce or even unavailable, assuming that the domains are related. Thus, the requirements w.r.t. the availability of labelled training samples in the target domain are reduced. In particular, if no labelled target data are available, it is inherently difficult to find a robust measure of relatedness between the source and target domains. This is of crucial importance for the performance of TL, because the knowledge transfer between unrelated data may lead to negative transfer, i.e. to a decrease of classification performance after transfer. We address the problem of measuring the relatedness between source and target datasets and investigate three different strategies to predict and, consequently, to avoid negative transfer in this paper. The first strategy is based on circular validation. The second strategy relies on the Maximum Mean Discrepancy (MMD) similarity metric, whereas the third one is an extension of MMD which incorporates the knowledge about the class labels in the source domain. Our method is evaluated using two different benchmark datasets. The experiments highlight the strengths and weaknesses of the investigated methods. We also show that it is possible to reduce the amount of negative transfer using these strategies for a TL method and to generate a consistent performance improvement over the whole dataset.
Aromatic Hydrocarbon Receptor Interaction with the Retinoblastoma Protein Potentiates Repression of E2F-dependent Transcription and Cell Cycle Arrest (2000)

Polyhalogenated aromatic hydrocarbons, of which 2,3,7, 8-tetrachloro-p-dioxin (TCDD) is the prototype compound, elicit a variety of toxic, teratogenic, and carcinogenic responses in exposed animals and in humans. In cultured cells, TCDD shows marked effects on the regulation of cell cycle progression, including thymocyte apoptosis, induction of keratinocyte proliferation and terminal differentiation, and inhibition of estrogen-dependent proliferation in breast cancer cells. The presence of an LXCXE domain in the dioxin aromatic hydrocarbon receptor (AHR), suggested that the effects of TCDD on cell cycle regulation might be mediated by protein-protein interactions between AHR and the retinoblastoma protein (RB). Using the yeast two-hybrid system, AHR and RB were in fact shown to bind to each other. In vitro pull-down experiments with truncated AHR peptides indicated that at least two separate AHR domains form independent complexes with hypophosphorylated RB. Coimmunoprecipitation of whole cell lysates from human breast carcinoma MCF-7 cells, which express both proteins endogenously, revealed that AHR associates with RB in vivo only after receptor transformation and nuclear translocation. However, the AHR nuclear translocator and transcriptional heterodimerization partner, is not required for (nor is it a part of) the AHR.RB complexes detected in vitro. Ectopic expression of AHR and RB in human osteosarcoma SAOS-2 cells, which lack endogenous expression of both proteins, showed that AHR synergizes with RB to repress E2F-dependent transcription and to induce cell cycle arrest. Furthermore, AHR partly blocked T-antigen-mediated reversal of RB-dependent transcriptional repression. These results uncover a potential function for the AHR in cell cycle regulation and suggest that this function may be that of serving as an environmental sensor that signals cell cycle arrest when cells are exposed to certain environmental toxicants.
Assessment of Cell-Cycle Arrest Biomarkers to Predict Early and Delayed Acute Kidney Injury (2015)

Urinary [TIMP-2]·[IGFBP7], NGAL, and cystatin-C should be used cautiously as AKI predictors in general ICU patients since urine levels of these biomarkers are affected by factors other than AKI and their performance can be poor.
Detection of heterozygous truncating mutations in the BRCA1 and APC genes by using a rapid screening assay in yeast (1997)

The detection of inactivating mutations in tumor suppressor genes is critical to their characterization, as well as to the development of diagnostic testing. Most approaches for mutational screening of germ-line specimens are complicated by the fact that mutations are heterozygous and that missense mutations are difficult to interpret in the absence of information about protein function. We describe a novel method using Saccharomyces cerevisiae for detecting protein-truncating mutations in any gene of interest. The PCR-amplified coding sequence is inserted by homologous recombination into a yeast URA3 fusion protein, and transformants are assayed for growth in the absence of uracil. The high efficiency of homologous recombination in yeast ensures that both alleles are represented among transformants and achieves separation of alleles, which facilitates subsequent nucleotide sequencing of the mutated transcript. The specificity of translational initiation of the URA3 gene leads to minimal enzymatic activity in transformants harboring an inserted stop codon, and hence to reliable distinction between specimens with wild-type alleles and those with a heterozygous truncating mutation. This yeast-based stop codon assay accurately detects heterozygous truncating mutations in the BRCA1 gene in patients with early onset of breast cancer and in the APC gene in patients with familial adenomatous polyposis. This approach offers a rapid and reliable method for genetic diagnosis in individuals at high risk for germ-line mutations in cancer susceptibility genes.
Bulk ion-clustering and surface ion-layering effects on work function of self-compensated charged-doped polymer semiconductors (2019)

Self-compensated hole- and electron-doped polyelectrolytes can afford 0.1 eV tuning steps in work function of charge injection/collection layers through the tethered anions. These material systems are further immune to ‘dopant’ migration.
Comparison of a dietary portfolio diet of cholesterol-lowering foods and a statin on LDL particle size phenotype in hypercholesterolaemic participants (2007)

The effect of diet v. statins on LDL particle size as a risk factor for CVD has not been examined. We compared, in the same subjects, the impact of a dietary portfolio of cholesterol-lowering foods and a statin on LDL size electrophoretic characteristics. Thirty-four hyperlipidaemic subjects completed three 1-month treatments as outpatients in random order: a very-low saturated fat diet (control); the same diet with 20 mg lovastatin; a dietary portfolio high in plant sterols (1 g/4200 kJ), soya proteins (21.4 g/4200 kJ), soluble fibres (9.8 g/4200 kJ) and almonds (14 g/4200 kJ). LDL electrophoretic characteristics were measured by non-denaturing polyacrylamide gradient gel electrophoresis of fasting plasma at 0, 2 and 4 weeks of each treatment. The reductions in plasma LDL-cholesterol levels with the dietary portfolio and with statins were comparable and were largely attributable to reductions in the estimated concentration of cholesterol within the smallest subclass of LDL (portfolio - 0.69 (se 0.10) mmol/l, statin - 0.99 (se 0.10) mmol/l). These were significantly greater (P < 0.01) than changes observed after the control diet ( - 0.17 (se 0.08) mmol/l). Finally, baseline C-reactive protein levels were a significant predictor of the LDL size responsiveness to the dietary portfolio but not to the other treatments. The dietary portfolio, like the statin treatment, had only minor effects on several features of the LDL size phenotype, but the pronounced reduction in cholesterol levels within the small LDL fraction may provide additional cardiovascular benefit over the traditional low-fat diet of National Cholesterol Education Program Step II.
A véralvadás XIII-as faktora = Blood coagulation factor XIII. (2007)

I. A XIII-as faktor (FXIII) struktúrája és funkciója Az aktivációs peptid nélkül a FXIII-A instabil. A FXIII aktivációt a plazmában a fibrin polimerizáció determinálja, a FXIII-A Val34Leu polimorfizmusnak csak moduláló hatása van. A FXIII A és B alegységének kapcsolódását gátló monoklonális antitestek előállítása. A celluláris FXIII szerepet játszik a monocyták/macrophagok phagocytosisában. Az alvadékban aktiválódó granulocytákból felszabadult proteázok lebontják a FXIIIa-t. II. Klinikai FXIII kutatások Új típusú módszer a FXIII (ill. más transzglutaminázok) mérésére, ill. a FXIII-A Val34Leu polimorfizmus kimutatására. Az intracelluláris FXIII-A áramlásos citometriás kimutatására új módszer, mely kiválóan alkalmazható az acut myleoid leukemiák diagnosztikájában. Csontvelő abláció során szignifikánsan csökken a plazma FXIII szintje, magas thrombocyta számmal járó myeloproliferatív megbetegedésekben viszont emelkedik. Nőkben az emelkediett FXIII szint több mint kétszeresére növeli a myocardiális infarctus rizikóját nőkben. Krónikus bronchoalveoláris megbetegedésekben jelentősen emelkedik a bronchoalveoláris mosófolyadékban a FXIII mennyisége. 4 új mutációt írtunk le FXIII hiányos betegekben, s analizáltuk ezek fehérje biokémiai következményeit. FXIII hiányíos transzgén egereken igazoltuk, hogy a FXIII szükséges a normális sebgyógyuláshoz. | I. Structure and function of factor XIII (FXIII) The absence of activation peptide makes FXIII-A instable. The activation of FXIII in the plasma is determined by fibrin polymerization; FXIII-A Val34Leu polymorphism only modulates activation. Production of monoclonal antibodies with inhibitory effect on the association of FXIII A and B subunits. Cellular FXIII plays a role in the phagocytosis by monocytes/macrophages. Proteases released from granulocytes in the clot break down activated FXIII. Clinical studies on FXIII New methods on the measurement of FXIII activity, and on the detection of FXIII-A Val34Leu polymorphism. Method on the detection of intracellular FXIII-A and its application to the diagnosis of acute myeloid leukemias. Bone marrow ablation results in the significant decrease of plasma FXIII level; in myeloproliferative diseases with high platelet count plasma FXIII is elevated. In women elevated FXIII level increases the risk for myocardial infarction by more than two-folds. In chronic bronchoalveolar inflammation the amount of FXIII in the lavage fluid is significantly increased. Description of four new mutations in FXIII deficient patients, and protein structural analysis of their consequences. It was demonstrated on FXIII deficient transgene mice that FXIII is required for normal wound healing.
Mineral bone disorders (MBD) in patients on peritoneal dialysis (2019)

Chronic kidney disease-mineral bone disorder (CKD-MBD) is a systemic disorder of mineral and bone metabolism. In patients undergoing peritoneal dialysis (PD), serum levels of calcium (Ca), phosphate (P), and parathyroid hormone (PTH) remain relatively constant, irrespective of the timing of treatment. This is because PD is a continuous blood purification procedure, and in this respect differs greatly from hemodialysis (HD), where the serum levels of these factors change following each dialysis session, and so pre-dialysis values are considered baseline values. Nevertheless, the target values for serum P, Ca, and PTH in PD patients are the same as those in HD patients. In PD patients, however, it is plausible to initiate correction of any of these values once any tendency towards worsening is observed, even if they are still within the upper limit of normal for HD patients. Restriction of dietary P intake, conservation of residual renal function for excretion of P, and prescription of an appropriate P binder are recommended to maintain the blood P level in the appropriate range. The use of a 2.5-mEq/L Ca concentration dialysate reduces the risk of hypercalcemia and allows correction of adynamic bone disease. Meanwhile, secondary hyperparathyroidism may progress in such cases. It is thus recommended that this factor be considered in prescribing this type of dialysate.
Thiazolylalanine-Derived Catalysts for Enantioselective Intermolecular Aldehyde−Imine Cross-Couplings (2005)

Catalytic asymmetric cross-coupling reactions between aldehydes and N-acylimines have been discovered that employ thiazolylalanine derivatives as catalysts. Alkylation of the thiazolyl moiety, followed by in situ generation of the derived thiazolium ylide using a tertiary amine base, leads to the active catalyst. alpha-Amidoketone products are isolated in up to 90% yield with up to 87% enantiomeric excess (>98% ee after a single recrystallization). The use of a hindered base to suppress product racemization was stimulated by a mechanistic study that revealed an isotope effect on the racemization rate of the product.
Synthesis, Characterization, and Reactivity of Fe Complexes Containing Cyclic Diazadiphosphine Ligands: The Role of the Pendant Base in Heterolytic Cleavage of H2 (2012)

The iron complexes CpFe(P(Ph)(2)N(Bn)(2))Cl (1-Cl), CpFe(P(Ph)(2)N(Ph)(2))Cl (2-Cl), and CpFe(P(Ph)(2)C(5))Cl (3-Cl)(where P(Ph)(2)N(Bn)(2) is 1,5-dibenzyl-1,5-diaza-3,7-diphenyl-3,7-diphosphacyclooctane, P(Ph)(2)N(Ph)(2) is 1,3,5,7-tetraphenyl-1,5-diaza-3,7-diphosphacyclooctane, and P(Ph)(2)C(5) is 1,4-diphenyl-1,4-diphosphacycloheptane) have been synthesized and characterized by NMR spectroscopy, electrochemical studies, and X-ray diffraction. These chloride derivatives are readily converted to the corresponding hydride complexes [CpFe(P(Ph)(2)N(Bn)(2))H (1-H), CpFe(P(Ph)(2)N(Ph)(2))H (2-H), CpFe(P(Ph)(2)C(5))H (3-H)] and H(2) complexes [CpFe(P(Ph)(2)N(Bn)(2))(H(2))]BAr(F)(4), [1-H(2)]BAr(F)(4), (where BAr(F)(4) is B[(3,5-(CF(3))(2)C(6)H(3))(4)](-)), [CpFe(P(Ph)(2)N(Ph)(2))(H(2))]BAr(F)(4), [2-H(2)]BAr(F)(4), and [CpFe(P(Ph)(2)C(5))(H(2))]BAr(F)(4), [3-H(2)]BAr(F)(4), as well as [CpFe(P(Ph)(2)N(Bn)(2))(CO)]BAr(F)(4), [1-CO]Cl. Structural studies are reported for [1-H(2)]BAr(F)(4), 1-H, 2-H, and [1-CO]Cl. The conformations adopted by the chelate rings of the P(Ph)(2)N(Bn)(2) ligand in the different complexes are determined by attractive or repulsive interactions between the sixth ligand of these pseudo-octahedral complexes and the pendant N atom of the ring adjacent to the sixth ligand. An example of an attractive interaction is the observation that the distance between the N atom of the pendant amine and the C atom of the coordinated CO ligand for [1-CO]BAr(F)(4) is 2.848 Å, considerably shorter than the sum of the van der Waals radii of N and C atoms. Studies of H/D exchange by the complexes [1-H(2)](+), [2-H(2)](+), and [3-H(2)](+) carried out using H(2) and D(2) indicate that the relatively rapid H/D exchange observed for [1-H(2)](+) and [2-H(2)](+) compared to [3-H(2)](+) is consistent with intramolecular heterolytic cleavage of H(2) mediated by the pendant amine. Computational studies indicate a low barrier for heterolytic cleavage of H(2). These mononuclear Fe(II) dihydrogen complexes containing pendant amines in the ligands mimic crucial features of the distal Fe site of the active site of the [FeFe]-hydrogenase required for H-H bond formation and cleavage.
V—P—O Catalysts in n-Butane Oxidation to Maleic Anhydride (1993)

The evolution of the structure of four vanadyl phosphate hemihydrates has been studied and then used as catalysts for n-butane oxidation using an in-situ Raman cell and 31P MAS-NMR. The catalytic performance for maleic anhydride formation can be explained by their transformation into αII and δ VOPO4 on the (VO)2P2O7 matrix as evidenced by Raman spectroscopy during the course of the reaction. The best catalytic results correspond to a limited number of V5+ sites forming small domains situated on and strongly interacting with the (100) (VO)2P2O7 crystalline face. This is therefore another example of a Structure Sensitive Reaction.