gebhart/patrepeval huggingface dataset:
Optimal Stochastic Operation of Integrated Low-Carbon Electric Power, Natural Gas, and Heat Delivery System (2017)

Integrated energy system is important for the high-efficient utilization of multitype energy systems. In this paper, the stochastic optimal operation is investigated for the micro integrated electric power, natural gas, and heat delivery system (IPGHS). First, a low-carbon micro-IPGHS is proposed with the comprehensive consideration of renewable generation, carbon-capture-based power-to-gas technology, and the combined power and heat units. Second, a scenario-based optimal operation model for micro-IPGHS is proposed to handle uncertainties in energy demand and renewable generation. In the proposed model, energy transactions between micro-IPGHS and upstream energy systems as well as constraints for battery storage, natural gas storage, and heat storage systems are considered. Finally, a case study is used for the proposed low-carbon micro-IPGHS to validate the optimal stochastic operation approach. The proposed integrated system can effectively utilize the variable clean energy for optimizing the delivery of the green operation in micro-IPGHS.
Rare and Common Variants Uncover the Role of the Atria in Coarctation of the Aorta (2022)

Coarctation of the aorta (CoA) and bicuspid aortic valve (BAV) often cooccur and are genetically linked congenital heart defects (CHD). While CoA is thought to have a hemodynamic origin from ventricular dysfunction, we provide evidence pointing to atrial hemodynamics based on investigating the genetic etiology of CoA. Previous studies have shown a rare <i>MYH6</i> variant in an Icelandic cohort, and two common deletions in the protocadherin α cluster (<i>PCDHA</i> delCNVs) are significantly associated with CoA and BAV. Here, analysis of a non-Icelandic white CHD cohort (<i>n</i> = 166) recovered rare <i>MYH6</i> variants in 10.9% of CoA and 32.7% of BAV/CoA patients, yielding odds ratios of 18.6 (<i>p</i> = 2.5 × 10<sup>-7</sup>) and 20.5 (<i>p</i> = 7.4 × 10<sup>-5</sup>) for the respective association of <i>MYH6</i> variants with CoA and BAV/CoA. In combination with the <i>PCHDA</i> delCNVs, they accounted for a third of CoA cases. Gene expression datasets for the human and mouse embryonic heart showed that both genes are predominantly expressed in the atria, not the ventricle. Moreover, cis-eQTLs analysis showed the <i>PCHDA</i> delCNV is associated with reduced atrial expression of <i>PCHDA10</i>, a gene in the delCNV interval. Together, these findings showed that <i>PCDHA/MYH6</i> variants account for a substantial fraction of CoA cases. An atrial rather than ventricular hemodynamic model for CoA is indicated, consistent with the known early atrial functional dominance of the human embryonic heart.
New approaches to the prevention and eradication of rabies (2003)

Despite significant progress in improving the pre- and postexposure prophylaxis of human rabies, the development of better and more cost-effective vaccines and antiviral therapeutics remains a major goal for the treatment of human rabies, the control of animal rabies and particularly for the eradication of rabies virus reservoirs in terrestrial wildlife. In this review, we discuss the structural requirements for an effective rabies vaccine, as well as new strategies currently in use for the development of safer and more potent rabies vaccines for rabies prophylaxis and eradication. Finally, we discuss new immune therapeutics aimed at replacing the conventional administration of antirabies immunoglobulin used in rabies post-exposure prophylaxis in humans.
Correction for desynchronization of EEG and fMRI clocks through data interpolation optimizes artifact reduction (2007)

Co-registration of EEG (Electroencephalogram)- and fMRI (functional magnetic resonance imaging) remains a challenge due to the large artifacts induced on the EEG by the MR (magnetic resonance) sequence gradient and RF pulses. We present an algorithm, based on the average-subtraction method, which is able to correct EEG data for gradient and RF pulse artifacts. We optimized artifact reduction by correcting the misalignment of EEG and fMRI data samples, resulting from the asynchronous sampling of EEG and fMRI data, through interpolation of EEG data. A clustering algorithm is proposed to account for the variability of the pulse artifact. Results show that the algorithm was able to keep the spontaneous brain activity while removing gradient and pulse artifacts with only a subtraction of selectively averaged data. Pulse artifact clustering showed that most of the variability was due to the time jitter of the pulse artifact markers. We show that artifact reduction by average-subtraction is optimized by interpolating the EEG data to correct for asynchronously sampled EEG and fMRI data.
Word Spotting and Recognition with Embedded Attributes (2014)

This paper addresses the problems of word spotting and word recognition on images. In word spotting, the goal is to find all instances of a query word in a dataset of images. In recognition, the goal is to recognize the content of the word image, usually aided by a dictionary or lexicon. We describe an approach in which both word images and text strings are embedded in a common vectorial subspace. This is achieved by a combination of label embedding and attributes learning, and a common subspace regression. In this subspace, images and strings that represent the same word are close together, allowing one to cast recognition and retrieval tasks as a nearest neighbor problem. Contrary to most other existing methods, our representation has a fixed length, is low dimensional, and is very fast to compute and, especially, to compare. We test our approach on four public datasets of both handwritten documents and natural images showing results comparable or better than the state-of-the-art on spotting and recognition tasks.
Synthesis and Structures of LiBH4 Complexes with N-Heterocycles [1] (2009)

LiBH 4 solutions in diethyl ether or tetrahydrofuran react with N-methylmorpholine, Nmethylimidazole or piperidine not only with the formation of adducts LiBH 4 (L) n (n = 1 or 3) but also with formation of amine boranes BH 3 (L). While LiBH 4 and N-methylimidazole form the 1 : 3 adduct 1, N-methylmorpholine produces the 1 : 1 adduct 2. In both cases the adducts contain hexacoordinated Li atoms. In 1 the Li atom is coordinated to three N atoms and three H atoms. However, in compound 2 the molecules are connected in the solid state with one another to form a two-dimensional polymer built from dimeric units (LiBH 4 )2 that are connected to adjacent dimeric units via the O and N atoms of the N-methylmorpholine ligand. Each of the Li atoms in 2 is connected to four H atoms via Li-H-B hydrogen bridges and an O and an N atom. The reaction of LiBH4 with piperidine leads to the compound (LiBH 4 ) 6 (HNC 5 H1 0 ) 16 , 3, which consists of two independent LiBH 4 (HNC 5 H 10 ) 3 molecules and two others of composition (LiBH 4 ) 2 (HNC 5 H 10 ) 5 containing penta- and hexacoordinated Li atoms.
IMPROVEMENT OF SOME POST-CONSUMER POLYPROPYLENE (rPP) BY MELT MODIFICATION WITH STYRENE-DIENE BLOCK COPOLYMERS (2017)

Nowadays, the polyolefins (polyethylene, polypropylene) are increasingly consumed in large amounts for many applications.This issue causes a concern regarding the environmental impact of the waste materials generated after the first use.Mechanical recycling of polyolefin wastes helps to conserve oil and gas resources and reduce the polymeric waste accumulation in environment.In this paper, the modification of some post-consumer polypropylene (rPP) properties coming from packaging processing is investigated by the use of styrene-isoprene-styrene triblock copolymers (SIS).Thus, SIS block copolymers up to 20 wt.% in content with respect to rPP were introduced into the melted polymeric matrix by means of a twin rolls under the processing temperature of 185-190 ºC.The mechanical, thermal and structural properties of rPP/SIS blends have been studied with regard both to the content of SIS from blends and of polystyrene (PS) from SIS.The obtained results showed that the used SIS block copolymers led to the decrease of the degree of crystallinity and to increase of crystallite sizes of blends, with SIS20-10% being the most pronounced effect.Although by introduction of SIS into rPP a slight decrease of tensile strength is recorded, a remarkable increase on elongation at break and impact strength of rPP/SIS blends are exhibited.The good mechanical properties were achieved even by using of 10 wt% SIS.
Low-Temperature Molten Salt Electrolytes for Membrane-Free Sodium Metal Batteries (2015)

The liquid metal battery (LMB) is attractive due to its simple construction, its circumvention of solid-state failure mechanisms and resultantly long lifetimes, and its particularly low levelized cost of energy. Here, we provide a study of a unique binary electrolyte, NaOH-NaI, in order to pursue a low-cost and low-temperature sodium-based liquid metal battery (LMB) for grid-scale electricity storage. Thermodynamic studies have confirmed a low eutectic melting temperature (220°C) as well as provided data to complete the phase diagram of this system. X-ray diffraction has further supported the existence of a recently discovered compound, Na7(OH)5I2, as well as offered initial evidence toward a NaI-rich compound displaying Pm-3m symmetry. These phase equilibrium data have then been used to optimize parameters from a two-sublattice thermodynamic solution model to provide a starting point for study of higher order systems. Further, a detailed electrochemical study has identified the voltage window and related oxidation/reduction reactions and found greatly improved stability of the pure sodium electrode against the electrolyte. Finally, an Na|NaOH-NaI|Pb-Bi proof-of-concept cell was assembled. This cell achieved over 100 cycles and displayed leakage currents below 0.40 mA/cm2. These results highlight an exciting class of low-melting molten salt electrolytes that may enable low cost grid-scale storage.
Expression and secretion of bovine .BETA.-lactoglobulin in Saccharomyces cerevisiae. (1990)

A bovine beta-lactoglobulin (beta-LG) was expressed in Saccharomyces cerevisiae carrying bovine pre-beta-LG cDNA and secreted into its growth medium. The expression plasmid was constructed by inserting the whole coding region of the cDNA encoding pre-beta-LG between the promoter and terminator of the yeast glyceraldehyde 3-phosphate dehydrogenase gene of pYG100, a yeast expression vector. In the supernatant of the yeast growth medium, beta-LG with a native conformation was detected by sandwich ELISA, and its amount was estimated to be 1.1 mg/l. A Western-immunoblotting analysis revealed that beta-LG secrected in the growth medium had the same mobility as that of authentic bovine beta-LG. The N-terminal sequence was also identical with that of authentic mature bovine beta-LG.
Permittivities of watermelon pulp and juice and correlation with quality (2013)

Permittivities from 10 to 4500 MHz at 24 'C were measured on pulp and juice of watermelons of different maturities with an open-ended coaxial-line probe and network analyzer. The dielectric constant of both materials decreased monotonically with increasing frequency and loss factor had minimum at about 1000 MHz. Moreover, the pulp and juice had very similar loss factor values at each frequency. Ionic conduction is the major loss mechanism at lower frequencies in this range, while dipolar losses are dominant at the higher frequencies. The best linear coefficients of determination, 0.8 and 0.69, were found at 4500 MHz for correlations between the loss tangent of juice and soluble solids content and between loss tangent of juice and soluble solids/pH, respectively. The penetration depth of electromagnetic energy in pulp and juice at 4500 MHz was 4mm. The study offers useful information in assessing watermelon quality from dielectric properties.
High-Folate Diets and Breast Cancer Survival in a Prospective Cohort Study (2002)

Recent evidence suggests that adequate dietary folate may attenuate the risk of breast cancer associated with intake of alcohol. However, patients with breast cancer have been commonly treated with antifolate chemotherapies. The present analysis was performed to test the hypothesis that high folate intake may diminish the effectiveness of chemotherapy and, therefore, adversely influence survival. Women at risk of postmenopausal breast cancer (n = 37,105) participated in the Iowa Women's Health Study. Total folate intake (diet + supplements) was estimated from a food frequency questionnaire administered at baseline in 1986 and categorized into tertiles. From all incident breast cancer cases ascertained in the cohort, we selected those with a diagnosis between 1986 and 1994, chemotherapy as first course of treatment, and adequate diet assessment. Mortality was determined through the State Health Registry of Iowa and the National Death Index. Cox regression was used to estimate survival while adjusting for important covariates. Through 14 yr of follow-up, 80 deaths occurred among the 177 breast cancer cases treated with chemotherapy. Among these patients, high folate intake was not associated with worse survival. After adjustment for age, extent of disease, total calories, alcohol, and estrogen receptor status, women with total folate intake in the highest tertile had a mortality risk ratio of 0.88 (95% confidence interval = 0.44-1.76) compared with cases in the lowest tertile of folate. These findings, although preliminary, afford some reassurance that folate supplementation is unlikely to have a significant adverse effect on survival after chemotherapy for breast cancer.
N,1-Bis(4-chloro-2-methylbenzyl)-3- methyl-2-oxo-1,2,3,4-tetrahydroquinoline-3-carboxamide (2023)

&lt;p&gt; In the title molecule, C27H26Cl2N2O2, the chloro-substituted benzene rings make dihedral angles of 83.29 (9) and 80.81 (9) with the benzene ring of the tetrahydroquinoline group. The dihedral angle formed by the two chloro-substituted benzene rings is 40.87 (12). The six-membered N-containing ring is in a half-chair conformation. In the crystal structure, intermolecular N—HO hydrogen bonds link molecules into centrosymmetric dimers. &lt;/p&gt;
<title>Convective influence on radial segregation during unidirectional solidification of the binary alloy HgCdTe</title> (1996)

In order to stimulate the space environment for basic research into the crystal growth mechanism, Hg<SUB>0.8</SUB>Cd<SUB>0.2</SUB>Te crystals were grown by the vertical Bridgman- Stockbarger method in the presence of an applied axial magnetic field. The influence of convection, by magneto hydrodynamic damping, on mass transfer in the melt and segregation at the solid-liquid interface was investigated by measuring he axial and radial compositional variations in the grown samples. The reduction of convective mixing in the melt through the application of the magnetic field is found to have a large effect on radial segregation and interface morphology in the grown crystals. Direct comparisons are made with a Hg<SUB>0.8</SUB>Cd<sub>0.2</sub>Te crystal grown without field and also in the microgravity environment of space during the second United States Microgravity Payload Mission.
The signal sequence receptor, unlike the signal recognition particle receptor, is not essential for protein translocation (1992)

Detergent extracts of canine pancreas rough microsomal membranes were depleted of either the signal recognition particle receptor (SR), which mediates the signal recognition particle (SRP)-dependent targeting of the ribosome/nascent chain complex to the membrane, or the signal sequence receptor (SSR), which has been proposed to function as a membrane bound receptor for the newly targeted nascent chain and/or as a component of a multi-protein translocation complex responsible for transfer of the nascent chain across the membrane. Depletion of the two components was performed by chromatography of detergent extracts on immunoaffinity supports. Detergent extracts lacking either SR or SSR were reconstituted and assayed for activity with respect to SR dependent elongation arrest release, nascent chain targeting, ribosome binding, secretory precursor translocation, and membrane protein integration. Depletion of SR resulted in the loss of elongation arrest release activity, nascent chain targeting, secretory protein translocation, and membrane protein integration, although ribosome binding was unaffected. Full activity was restored by addition of immunoaffinity purified SR before reconstitution of the detergent extract. Surprisingly, depletion of SSR was without effect on any of the assayed activities, indicating that SSR is either not required for translocation or is one of a family of functionally redundant components.
The neurophysiological basis of an adaptation to stress (2008)

われわれはストレス適応の神経生理学的基盤を明らかにするために，脳機能画像解析法を用いた検討を行っている．本稿ではその研究成果を中心に報告する．健常人を対象としたfMRIおよびMEGを用いた検討から，ストレス事象は脳内において認知されること，急性のストレスにより脳内機構の一部に変化が生じること，予測がストレス事象の入力を抑制する可能性などが考えられた．さらに，これらの機能において前頭前野を含む脳内ネットワークが重要な役割を果たしていることが推定された．また，うつ病患者を対象とした研究からは，これらの脳内機構が障害を来していることが推測され，今後，これらの研究結果をふまえて，ストレスへの適応を強化するための方策を検討していくことが重要と考えられた．
Reactions and nuclear magnetic resonance studies of allylic Wittig ylides (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions and nuclear magnetic resonance studies of allylic Wittig ylidesRobert K. HoweCite this: J. Am. Chem. Soc. 1971, 93, 14, 3457–3462Publication Date (Print):July 1, 1971Publication History Published online1 May 2002Published inissue 1 July 1971https://doi.org/10.1021/ja00743a027Request reuse permissionsArticle Views466Altmetric-Citations105LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (758 KB) Get e-Alertsclose Get e-Alerts
Laboratory performance of a dynamic ice storage system (1991)

The performance of a commercial 30-ton dynamic ice storage system was measured in a dedicated laboratory test facility and the results analyzed. The ice storage system was tested over a wide range of operating conditions to characterize the ice generating performance as a function of condensing conditions, ice build time, and defrost time. The overall efficiency of ice production was determined and the effect of refrigeration system component performance on the overall system efficiency was evaluated. The ability of the charged system -- a tank of ice slush -- to meet a simulated cooling load over was also evaluated. 18 refs., 9 figs.
Transposon-based vector systems for gene therapy clinical trials: challenges and considerations. (2012)

Much progress has been made in gene therapy, but significant challenges remain. One is development of a range of different tools that can be used for different therapeutic purposes. Another is site-specific gene targeting for safe and faithful therapeutic gene expression. Viruses have long been considered the most promising tools for human gene therapy. However, fatal side effects associated with viral vectors have hampered their clinical application. DNA transposons, widely utilized for decades as genetic tools in plants and insects, are now emerging as viable vectors for gene therapy. In this article, we will give a brief review of the adverse effects associated with virus-based gene therapy followed by a glimpse of the adeno-associated virus vector system, which is currently the most promising viral vector for gene therapy. The development of DNA transposon-based gene delivery systems and the advantages and limits of the most commonly used DNA transposon systems, Sleeping Beauty, Tol2, and piggyBac, will be extensively discussed Finally, we will focus on the most promising transposon system for gene therapy, piggyBac. Challenges and considerations for advancing piggyBac for therapeutic application will be critically addressed.
Data from FDA Approval Summary: Ivosidenib for Relapsed or Refractory Acute Myeloid Leukemia with an Isocitrate Dehydrogenase-1 Mutation (2023)

&lt;div&gt;Abstract&lt;p&gt;The FDA approved ivosidenib (Tibsovo; Agios), a small-molecule inhibitor of isocitrate dehydrogenase (IDH)1 on July 20, 2018, for treatment of adults with relapsed or refractory acute myeloid leukemia (R/R AML) with susceptible IDH1 mutation as detected by an FDA-approved test. The efficacy of ivosidenib was established on the basis of complete remission (CR) + CR with partial hematologic recovery (CRh) rate, duration of CR + CRh, and conversion from transfusion dependence (TD) to transfusion independence (TI) in Study AG120-C-001, a single-arm trial. With median follow-up of 8.3 months for 174 adults with IDH1-mutated R/R AML treated with 500 mg ivosidenib daily, the CR + CRh rate was 33% [95% confidence interval (CI), 26–40], median duration of response was 8.2 (95% CI, 5.6–12) months, and conversion from TD to TI occurred in 37% of patients. These endpoints reflect short-term benefit in patients with an unmet medical need; long-term efficacy outcomes were not assessed. Serious adverse reactions (AR) in ≥5% of patients were differentiation syndrome (10%), leukocytosis (10%), and QT interval prolongation (7%). Common (≥20%) ARs of any grade were fatigue, leukocytosis, arthralgia, diarrhea, dyspnea, edema, nausea, mucositis, QT interval prolongation, rash, pyrexia, cough, and constipation. Assessment of long-term safety of ivosidenib is a condition of this approval.&lt;/p&gt;&lt;/div&gt;
ICTV Virus Taxonomy Profile: Geminiviridae 2021 (2021)

The family <i>Geminiviridae</i> includes viruses with mono- or bipartite single-stranded, circular DNA genomes of 2.5-5.2 kb. They cause economically important diseases in most tropical and subtropical regions of the world. Geminiviruses infect dicot and monocot plants and are transmitted by insect vectors. DNA satellites are associated with some geminiviruses. This is a summary of the International Committee on Taxonomy of Viruses (ICTV) Report on the family <i>Geminiviridae</i> which is available at ictv.global/report/geminiviridae.
A mode of action of antibiotics in chick nutrition (1952)

Abstract Procaine penicillin [penicillin (procaine salt)] added to a good practical ration improved the growth of chicks in a laboratory used for poultry for ten years. Chicks from the same batch in two other laboratories, where birds had not been kept before, grew equally well on the ration with and without penicillin, and growth was the same as that on the penicillinsupplemented diet in the usual chick laboratory. The growth depression in the absence of dietary penicillin was not due to differences in management or to recognizable disease. It is suggested that it is due to an ‘infection’ hitherto undescribed and shown to be transmissible and counteracted by penicillin.