gebhart/patrepeval huggingface dataset:
Intraoperative Imaging with a Portable Gamma Camera May Reduce the False-Negative Rate for Melanoma Sentinel Lymph Node Surgery (2018)

Intraoperative PGC imaging yielded additional SLNs in a significant number of patients over GP alone. Identification of these additional SLNs resulted in upstaging of four patients with two patients being converted from a negative to a positive status, thus, preventing two false-negative cases.
詳解iOS SDK : ワンランク上のiPhone/iPadプログラミング (2014)

第１部 ビュー（ビュー；描画 ほか） 第２部 インタフェース（ビューコントローラ；スクロールビュー ほか） 第３部 フレームワーク（オーディオ；ビデオ ほか） 第４部 その他の話題（永続性記憶；基本的なネットワーク機能 ほか） 付録 アプリケーションのライフタイムイベント
Towards a software architecture for DRM (2005)

The domain of digital rights management (DRM) is currently lacking a generic architecture that supports interoperability and reuse of specific DRM technologies. This lack of architectural support is a serious drawback in light of the rapid evolution of a complex domain like DRM. It is highly unlikely that a single DRM technology or standard will be able to support the diversity of devices, users, platforms, and media, or the wide variety of system requirements concerning security, flexibility, and efficiency. This paper analyses state-of-the-art DRM technologies and extracts from them high level usage scenarios according to content consumers, producers, and publishers. In addition, the key services are identified both from a functional and security perspective. Identifying key DRM services and locating them in an overall structure brings us one step closer to a software architecture for DRM. Having available a software architecture should help the DRM community in reasoning about DRM systems, and in achieving reuse and interoperability of multiple domain-specific DRM technologies and standards.
Adjuvant Imatinib for High-Risk GI Stromal Tumor: Analysis of a Randomized Trial (2015)

Three years of adjuvant imatinib therapy results in longer survival than 1 year of imatinib. High 5-year survival rates are achievable in patient populations with high-risk GIST.
The size and flexibility of grown sodium dodecyl sulfate micelles in aqueous sodium chloride solutions (1990)

We have used light scattering techniques to measure the size and flexibility of grown sodium dodecyl sulfate (SDS) micelles in aqueous NaCl solutions as a function of temperature, surfactant concentration, and salt concentration. The mean hydrodynamic radius (R̄h) was determined using quasielastic light scattering, and the mean radius of gyration (R̄g) was measured using static light scattering. A theory of flexible rod-like objects is compared to the data. This theory predicts that for flexible rod-like micelles R̄g/R̄h will depend not only on R̄h but also on the persistence length, a measure of micellar flexibility. The data are found to be consistent with flexible rod-like micelles whose mean persistence length (〈l〉) depends weakly on SDS concentration and strongly on temperature and NaCl concentration. In the temperature range from 20–37 °C in 0.8 M NaCl and 30–50 °C in 1 M NaCl solution we find 〈l〉∝exp(−w/kBT) with w=4.7±0.5×10−12 erg.
Modeling of Smart Pigging for Pipeline Leak Detection (2020)

Summary Although leak incidents continue, a pipeline remains the most reliable mode of transportation within the oil and gas industry. It becomes even more important today because the projection for new pipelines is expected to increase by 1 billion barrels of oil equivalent (BOE) through 2035. In addition, increasing the number and length of subsea tiebacks faces new challenges in terms of data acquisition, monitoring, analysis, and remedial actions. Passive leak-detection methods commonly used in the industry have been successful with some limitations, in that they often cannot detect small leaks and seeps. In addition to a thorough review of related topics, this study investigates how to create a framework for a smart pigging technique for pipeline leak detection as an active leak-detection method. Numerical modeling of smart pigging for leak detection requires two crucial components: detailed mathematical descriptions for fluid-solid and solid-solid interactions around pig and network modeling for the calculation of pressure and rate along the pipeline using iterative algorithms. The first step of this study is to build a numerical model that shows the motion of a pig along the pipeline with no leak (i.e., at a given injection rate, a pig first accelerates until it reaches its terminal velocity, beyond which the pig moves at a constant velocity). The second step is to construct a network model that consists of two pipeline segments (one upstream and the other downstream of the leak location) through which the pig travels and at the junction of which fluid leak occurs. By putting these multiple mechanisms together and using resulting pressure signatures, this study presents a new method to predict the location and size of a leak in the pipeline.
On-Chip Transient Detection Circuit for Microelectronic Systems Against Electrical Transient Disturbances due to ESD Events (2018)

A new on-chip transient detection circuit which can detect electrical disturbances of system-level electrostatic discharge (ESD) is proposed. The circuit is designed with reduced physical area by utilizing dual-latched structure. With hardware/firmware co-design method, auto-recovery procedure can be activated by the detection circuit when microelectronic systems suffer system-level ESD events. The immunity level of microelectronic products against the electromagnetic interference (EMI) of ESD events can be effectively improved. The proposed on-chip transient detection circuit has been verified in a <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$0.18-\boldsymbol{\mu}\mathbf{m}$</tex> eMos process with 1.8-V devices under system-level ESD tests.
AGGRESSIVE, DEFINITIVE MANAGEMENT OF PENETRATING COLON INJURIES (1983)

Nallachambi, M. M.D.; Ivatury, R. M.D.; Shah, P. M.D.; Caudino, J. M.D.; Stahl, W. M.D. Author Information
Optimal Deployment of SRv6 to Enable Network Interconnection Service (2021)

Many organizations nowadays have multiple sites at different geographic locations. Typically, transmitting massive data among these sites relies on the interconnection service offered by ISPs. Segment Routing over IPv6 (SRv6) is a new simple and flexible source routing solution which could be leveraged to enhance interconnection services. Compared to traditional technologies, e.g., physical leased lines and MPLS-VPN, SRv6 can easily enable quick-launched interconnection services and significantly benefit from traffic engineering with SRv6-TE. To parse the SRv6 packet headers, however, hardware support and upgrade are needed for the conventional routers of ISP. In this paper, we study the problem of SRv6 incremental deployment to provide a more balanced interconnection service from a traffic engineering view. We formally formulate the problem as an SRID problem with integer programming. After transforming the SRID problem into a graph model, we propose two greedy methods considering short-term and long-term impacts with reinforcement learning, namely GSI and GLI. The experiment results using a public dataset demonstrate that both GSI and GLI can significantly reduce the maximum link utilization, where GLI achieves a saving of 59.1&#x0025; against the default method.
Event-Based Eccentric Motion Detection Exploiting Time Difference Encoding (2020)

Attentional selectivity tends to follow events considered as interesting stimuli. Indeed, the motion of visual stimuli present in the environment attract our attention and allow us to react and interact with our surroundings. Extracting relevant motion information from the environment presents a challenge with regards to the high information content of the visual input. In this work we propose a novel integration between an eccentric down-sampling of the visual field, taking inspiration from the varying size of receptive fields (RFs) in the mammalian retina, and the Spiking Elementary Motion Detector (sEMD) model. We characterize the system functionality with simulated data and real world data collected with bio-inspired event driven cameras, successfully implementing motion detection along the four cardinal directions and diagonally.
TS-MPC for Autonomous Vehicles Including a TS-MHE-UIO Estimator (2019)

In this paper, a novel approach is presented to solve the trajectory tracking problem for autonomous vehicles. This approach is based on the use of a cascade control where the external loop solves the position control using a novel Takagi Sugeno-Model Predictive Control (TS-MPC) approach and the internal loop is in charge of the dynamic control of the vehicle using a Takagi Sugeno-Linear Quadratic Regulator technique designed via Linear Matrix Inequalities (TS-LMI-LQR). Both techniques use a TS representation of the kinematic and dynamic models of the vehicle. In addition, a novel Takagi-Sugeno estimator-Moving Horizon Estimator-Unknown Input Observer (TS-MHE-UIO) is presented. This method estimates the dynamic states of the vehicle optimally as well as the force of friction acting on the vehicle that is used to reduce the control efforts. The innovative contribution of the TS-MPC and TS-MHE-UIO techniques is that using the TS model formulation of the vehicle allows us to solve the nonlinear problem as if it were linear, reducing computation times by 10-20 times. To demonstrate the potential of the TS-MPC, we propose a comparison between three methods of solving the kinematic control problem: Using the nonlinear MPC formulation (NL-MPC) with compensated friction force, the TS-MPC approach with compensated friction force, and TS-MPC without compensated friction force.
Robotic Exploration of the Surface and Atmosphere of Venus (2004)

Venus, the planet, is a scientifically fascinating place. In many ways it can be considered evil twin. A huge number of important scientific questions remain to be answered: 1) Before the runaway greenhouse effect, was early Venus temperate? 2) Did Venus once have an ocean? 3) What causes the geological resurfacing of the planet? 4) Is Venus still geologically active? 5) What is the snow on Venus mountaintops? 6) Can we learn about Earth's climate from Venus? 7) Is the atmosphere of Venus suitable for life? To address these and other scientific questions, a robotic mission to study the surface and atmosphere of Venus has been designed. The mission includes both surface robots, designed with an operational lifetime of 90 days on the surface of Venus, and also solar-powered airplanes to probe the middle atmosphere. At 450 Celsius, and with 90 atmospheres of pressure of carbon-dioxide atmosphere, the surface of Venus is a hostile place for operation of a probe. This paper will present the mission design, discuss the technology options for materials, power systems, electronics, and instruments, and present a short summary of the mission.
Insertion of O2 into a Chromium-Phenyl Bond: Mechanism of Formation of the Paramagnetic d2 Oxo Complex [TptBu,MeCrIV(O)OPh] (1999)

A dioxygen adduct is the spectroscopically observable intermediate in the reaction of the coordinatively unsaturated chromium phenyl complex 1 with O2 [Eq. (1)]. Intramolecular insertion of O2 into the Cr−C bond yields the title complex (2), which has been structurally characterized.
Polygenic overlap and shared genetic loci between loneliness, severe mental disorders, and cardiovascular disease risk factors suggest shared molecular mechanisms (2021)

Clinical and epidemiological evidence suggest that loneliness is associated with severe mental disorders (SMDs) and increases the risk of cardiovascular disease (CVD). However, the mechanisms underlying the relationship between loneliness, SMDs, and CVD risk factors remain unknown. Here we explored overlapping genetic architecture and genetic loci shared between SMDs, loneliness, and CVD risk factors. We analyzed large independent genome-wide association study data on schizophrenia (SCZ), bipolar disorder (BD), major depression (MD), loneliness and CVD risk factors using bivariate causal mixture mode (MiXeR), which estimates the total amount of shared variants, and conditional false discovery rate to evaluate overlap in specific loci. We observed substantial genetic overlap between SMDs, loneliness and CVD risk factors, beyond genetic correlation. We identified 149 loci jointly associated with loneliness and SMDs (MD n = 67, SCZ n = 54, and BD n = 28), and 55 distinct loci jointly associated with loneliness and CVD risk factors. A total of 153 novel loneliness loci were found. Most of the shared loci possessed concordant effect directions, suggesting that genetic risk for loneliness may increase the risk of both SMDs and CVD. Functional analyses of the shared loci implicated biological processes related to the brain, metabolic processes, chromatin and immune system. Altogether, the study revealed polygenic overlap between loneliness, SMDs and CVD risk factors, providing new insights into their shared genetic architecture and common genetic mechanisms.
Auxiliary Bearing System Optimization for AMB Supported Rotors Based on Rotor Drop Analysis: Part I — Rotor Drop Analysis Method (2016)

For rotors supported with active magnetic bearings (AMBs), the auxiliary bearing system or backup bearing system is needed to avoid serious potential internal damaging in the event of AMB loss of power or overload. The evolution of auxiliary systems has been made a priority by the American Petroleum Institute using analytical or experimental methods. In part I of this paper, a detailed rotor drop nonlinear transient analysis method including flexible shaft, rolling element bearing components including inner/outer races and balls, as well as flexible/damped supporting structures is given. A finite element based 6-DOF flexible rotor model is used to indicate shaft motion before the drop (operating conditions) and during the rotor drop event. Un-lubricated Hertzian contact models are used between the shaft and inner/outer races, between balls and races. To avoid heavy calculating time, two different methods to calculate ball bearing contact loads are discussed and the simulation results are compared. These models are applied to predict shaft-race-ball displacements and angular speeds, contact loads and ball bearing stresses during the drop for angular contact auxiliary bearings. This method also can be used to design and optimize the auxiliary bearing system as presented in the 2nd part of this paper.
Analysis of Japanese compound nouns by direct text scanning (1996)

This paper aims to analyze word dependency structure in compound nouns appearing in Japanese newspaper articles. The analysis is a difficult problem because such compound nouns can be quite long, have no word boundaries between contained nouns, and often contain unregistered words such as abbreviations. The non-segmentation property and unregistered words cause initial segmentation errors which result in erroneous analysis. This paper presents a corpus-based approach which scans a corpus with a set of pattern matchers and gathers cooccurrence examples to analyze compound nouns. It employs boot-strapping search to cope with unregistered words: if an unregistered word is found in the process of searching the examples, it is recorded and invokes additional searches to gather the examples containing it. This makes it possible to correct initial oversegmentation errors, and leads to higher accuracy. The accuracy of the method is evaluated using the compound nouns of length 5, 6, 7, and 8. A baseline is also introduced and compared.
New Anthracycline Antibiotic CG12 Obtained by Microbial Glycosidation ofα-Citromycinone (1986)

Journal Article New Anthracycline Antibiotic CG12 Obtained by Microbial Glycosidation of α-Citromycinone Get access Osamu Johdo, Osamu Johdo Central Research Laboratories, Sanraku Incorporated Johnan 4-chome, 9–1, Fujisawa, Kanagawa 251, Japan Search for other works by this author on: Oxford Academic Google Scholar Akihiro Yoshimoto, Akihiro Yoshimoto Central Research Laboratories, Sanraku Incorporated Johnan 4-chome, 9–1, Fujisawa, Kanagawa 251, Japan Search for other works by this author on: Oxford Academic Google Scholar Tomoyuki Ishikura, Tomoyuki Ishikura Central Research Laboratories, Sanraku Incorporated Johnan 4-chome, 9–1, Fujisawa, Kanagawa 251, Japan Search for other works by this author on: Oxford Academic Google Scholar Hiroshi Naganawa, Hiroshi Naganawa Institute of Microbial Chemistry, Kamiosaki, Shinagaw a-ku, Tokyo 141, Japan Search for other works by this author on: Oxford Academic Google Scholar Tomio Takeuchi, Tomio Takeuchi Institute of Microbial Chemistry, Kamiosaki, Shinagaw a-ku, Tokyo 141, Japan Search for other works by this author on: Oxford Academic Google Scholar Hamao Umezawa Hamao Umezawa Institute of Microbial Chemistry, Kamiosaki, Shinagaw a-ku, Tokyo 141, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 50, Issue 6, 1 June 1986, Pages 1657–1659, https://doi.org/10.1080/00021369.1986.10867629 Published: 01 June 1986 Article history Received: 13 January 1986 Published: 01 June 1986
Mucho más que un 1%: la verdadera cantidad de diferencias entre humanos y chimpancés (2018)

Este artículo trata de la diferencia del genoma de los humanos y de otras especies de primates. Este difiere en más de un 1%, lo que ha constituido una creencia común hasta este mismo año. En realidad, difieren hasta en un 10% y la naturaleza de estas diferencias es tal que bien podría haber sido la fuente más importante de novedad evolutiva y adaptación en nuestro linaje
The Steroid Hormonal Milieu of the Undisturbed Human Fetus and Mother at 16–20 Weeks Gestation* (1991)

The interrelations of steroid hormone levels in plasma and amniotic fluid from mothers and their undisturbed fetuses at early midgestation of human pregnancy have not been defined previously. We, therefore, studied 12 healthy mothers and their fetuses undergoing termination of pregnancy for social reasons at 16-20 weeks gestation. Fetal arterial and venous blood was obtained by direct vessel puncture through a fetoscope in the conscious sedated mothers immediately before termination of pregnancy. Simultaneously, maternal peripheral venous blood and amniotic fluid were collected. Aldosterone (Aldo), corticosterone (B), 11-deoxycorticosterone, progesterone (P), 17-hydroxyprogesterone (17OHP), 11-deoxycortisol, cortisol (F), and cortisone were simultaneously determined by specific RIA after extraction and chromatography. Positive fetal arterio-venous differences were found for F, B, and Aldo, whereas arteriovenous differences were negative for P and 17OHP. In amniotic fluid, six of the eight corticosteroids showed significantly lower levels during fetoscopy than during routine amniocentesis, as reported previously using the same analytical methods. The present study demonstrates that the undisturbed human fetus at 16-20 weeks gestation actively secretes the most important gluco- and mineralocorticoids, F, B, and Aldo, independent of the mother. P and 17OHP were shown to be primarily derived from placental production and supplied to the fetus as a source of F and Aldo biosynthesis. The fetoscopy procedure with premedication seemed to give rise to less stress to the fetus than routine amniocentesis without sedation. Fetoscopy is, therefore, an ideal method to study feto-maternal steroid interrelations in human pregnancy.
Homoleptic, heteroleptic and mixed-valent thallium and indium complexes of multidentate chalcogen-centred PCP-bridged ligands (2011)

The metathetical reaction of [Li(TMEDA)][HC(PPh(2)Se)(2)] ([Li(TMEDA)]1) with TlOEt in a 1:1 molar ratio afforded a homoleptic Tl(I) complex as an adduct with LiOEt, Tl[HC(PPh(2)Se)(2)]·LiOEt (7), which undergoes selenium-proton exchange upon mild heating (60 °C) to give the mixed-valent Tl(I)/Tl(III) complex {[Tl][Tl{(Se)C(PPh(2)Se)(2)}(2)]}(∞) (8). Treatment of TlOEt with [Li(TMEDA)](2)[(SPh(2)P)(2)CE'E'C(PPh(2)S)(2)] (3b, E' = S; 3c, E' = Se) in a 2:1 molar ratio produced the binuclear Tl(i)/Tl(i) complexes Tl(2)[(SPh(2)P)(2)CE'E'C(PPh(2)S)(2)] (9b, E' = S; 9c, E' = Se), respectively. Selenium-proton exchange also occurred upon addition of [Li(TMEDA)]1 to InCl(3) to yield the heteroleptic complex (TMEDA)InCl[(Se)C(PPh(2)Se)(2)] (10a). Other examples of this class of In(III) complex, (TMEDA)InCl[(E')C(PPh(2)E)(2)] (10b, E = E' = S; 10c, E = S, E' = Se) were obtained via metathesis of InCl(3) with [Li(TMEDA)](2)[(E')C(PPh(2)E)(2)] (2b, E = E' = S; 2c, E = S, E' = Se, respectively). All new compounds have been characterized in solution by (1)H and (31)P NMR spectroscopy and the solid-state structures have been determined for 8, 9c and 10a-c by single-crystal X-ray crystallography. Complex 8 is comprised of Tl(+) ions that are weakly coordinated to octahedral [Tl{(Se)C(PPh(2)Se)(2)}(2)](-) anions to give a one-dimensional polymer. The complex 9c is comprised of two four-coordinate Tl(+) ions that are each S,S',S'',Se bonded to the hexadentate [(SPh(2)P)(2)CSeSeC(PPh(2)S)(2)](2-) ligand in which d(Se-Se) = 2.531(2) Å. The six-coordinate In(III) centres in the distorted octahedral complexes 10a-c are connected to a tridentate [(E')C(PPh(2)E)(2)](2-) dianion, a chloride ion and a neutral bidentate TMEDA ligand.
Investigating the Deoxyribonuclease Activity of CRM197 with Site-Directed Mutagenesis (2019)

The protein cross-reactive material 197 (CRM197) is known to catalyze the hydrolytic cleavage of DNA (DNase activity). A suspected metal-binding site (S109, T111, and E112) and suspected DNA-binding motif (T89, K90, and V91) were predicted within the CRM197 protein X-ray crystal structure (4AE0) using METSITE and DNABindProt, respectively. Between these two predicted sites is a groove (K103, E116, T120, E122, F123, and R126) that may assist in DNase activity. Alanine scanning was performed at these sites to determine which amino acids might be important for DNase activity. These mutations individually or in combination either maintained or increased the overall DNase activity compared to the unmodified CRM197. Mutation at the suspected metal-binding site showed similar fluctuations to the overall DNase activity whether the DNase assays were run with Mg<sup>2+</sup> and Ca<sup>2+</sup> or Mn<sup>2+</sup>. However, many of the mutations within the suspected DNA-binding motif saw significant differences depending on which metal was used. Only some of the improvements in DNase activity could be attributed to improved folding of the mutants compared to the unmodified CRM197. This study should provide a basis for further mutagenesis studies to remove the DNase activity of CRM197.