gebhart/patrepeval huggingface dataset:
Differential responses ofArabidopsis thalianaaccessions to atmospheric nitrogen dioxide at ambient concentrations (2014)

To better understand the response of plants to atmospheric nitrogen dioxide (NO2), we investigated biomass accumulation in 3 accessions of Arabidopsis thaliana: C24, Columbia (Col-0), and Landsberg erecta (Ler). Plants were grown in NO2-free air for 1 week after sowing, followed by 3 (Col-0 and Ler) to 4 (C24) weeks in air with or without NO 2 (10 or 50 ppb). NO2 treatment increased the biomass of all 3 accessions to varying extents. Treatment with 10 ppb NO2 increased shoot biomass in C24, Col-0, and Ler by 3.2-, 1.4-, and 2.3-fold, respectively, compared with control. Treatment with 50 ppb gave similar increases, except in C24 (2.7-fold). The physiological, evolutionary, and genetic significance of these results are discussed below.
Saturation monitoring of VX15/2503, a novel semaphorin 4D‐specific antibody, in clinical trials (2015)

This assay specifically and reproducibly measured cSEMA4D saturation and expression levels. Evaluation of the SEMA4D-specific PD markers were critical in determining the clinical saturation threshold of cSEMA4D by VX15/2503.
Unprecedented Alexandrium blooms in a previously low biotoxin risk area of Tasmania, Australia (2017)

During October 2012, a shipment of blue mussels (Mytilus galloprovincialis) from the poorly monitored east coast of Tasmania, Australia, was tested by Japanese import authorities and found to be contaminated with unacceptable levels of Paralytic Shellfish Toxins (PSTs; 10 mg/kg). Subsequently local oysters, scallops, clams, the viscera of abalone and rock lobsters were also found to be contaminated. This led to a global product recall and loss to the local economy of AUD 23M. Following low toxicity during 2013 and 2014 and implementation of minimal shellfish farm closures, a more severe bloom event occurred during July-November 2015 and again June-September 2016 (up to 300,000 Alexandrium cells/L; 24 mg/kg PST in mussels, 6 mg/kg in Crassostrea gigas oysters), also causing 4 human illnesses resulting in hospitalization after consumption of wild shellfish. While Alexandrium tamarense had been detected in low concentrations in southeastern Australia since 1987, all cultured strains belonged to the mostly non-toxic group 5 (now designated A. australiense; detected since 1987) and weakly toxic group 4 (A. pacificum; detected in 1997). In contrast, the 2012 to 2016 outbreaks were dominated by highly toxic group 1 (A. fundyense) never detected previously in the Australian region. Molecular analyses suggest that A. fundyense may have been a cryptic ribotype previously present in Tasmania, but newly stimulated by altered water column stratification conditions driven by changing rainfall and temperature patterns. Increased seafood and plankton monitoring of the area now include the implementation of Alexandrium qPCR, routine Neogen™ immunological and HPLC PST tests, but ultimately may also drive change in harvesting strategies and aquaculture species selection by the local seafood industry.
Gene expression and molecular changes in cerebral arteries following subarachnoid hemorrhage in the rat (2006)

Processes occurring after SAH lead to enhanced arterial contractility and ECM remodeling either directly or through angiogenesis and inflammation. These processes are active via an increase in metalloproteinase expression, the presence of proangiogenic factors, and the expression of proinflammatory genes.
Formalin Removal from Archival Tissue by Critical Point Drying (2002)

The extraction of high-quality nucleic acid may be problematic in formalin-fixed tissues because of cross-linking between proteins and DNA. Old fixed tissue specimens do produce fragmented DNA (<1.2 kb), which is only used for PCR amplification. Here we show that high molecular weight DNA (>194 kb) can be successfully extracted from fixed tissue samples (16-70 years old) by gradual dehydration and critical point drying. The reliability of extracted DNA was measured by its ability to serve as a template for the amplification of mtDNA fragments (403 and 1198 bp) and an nDNA fragment (1844 bp). In addition, fingerprinting analysis was performed using DNA from fixed human tissue to ensure the ability of extracted DNA to hybridize with the DNA probe. DNA derived by this method can be subject to amplification, complete digestion by restriction endonuclease, and hybridization.
A Review of Indocyanine Green Fluorescent Imaging in Surgery (2012)

The purpose of this paper is to give an overview of the recent surgical intraoperational applications of indocyanine green fluorescence imaging methods, the basics of the technology, and instrumentation used. Well over 200 papers describing this technique in clinical setting are reviewed. In addition to the surgical applications, other recent medical applications of ICG are briefly examined.
Influence du gaz de protection sur le procédé de soudage MIG-MAG: du mode de transfert globulaire à la pulvérisation axiale (2013)

Communication orale (Q.Castillon)
Analysis of RhoA-binding Proteins Reveals an Interaction Domain Conserved in Heterotrimeric G Protein β Subunits and the Yeast Response Regulator Protein Skn7 (1998)

To identify potential RhoA effector proteins, we conducted a two-hybrid screen for cDNAs encoding proteins that interact with a Gal4-RhoA.V14 fusion protein. In addition to the RhoA effector ROCK-I we identified cDNAs encoding Kinectin, mDia2 (a p140 mDia-related protein), and the guanine nucleotide exchange factor, mNET1. ROCK-I, Kinectin, and mDia2 can bind the wild type forms of both RhoA and Cdc42 in a GTP-dependent manner in vitro. Comparison of the ROCK-I and Kinectin sequences revealed a short region of sequence homology that is both required for interaction in the two-hybrid assay and sufficient for weak interaction in vitro. Sequences related to the ROCK-I/Kinectin sequence homology are present in heterotrimeric G protein beta subunits and in the Saccharomyces cerevisiae Skn7 protein. We show that beta2 and Skn7 can interact with mammalian RhoA and Cdc42 and yeast Rho1, both in vivo and in vitro. Functional assays in yeast suggest that the Skn7 ROCK-I/Kinectin homology region is required for its function in vivo.
Microfluidic device for coupling isotachophoretic sample focusing with nanopore single-molecule sensing (2020)

Solid-state nanopores (NPs) are label-free single-molecule sensors, capable of performing highly sensitive assays from a small number of biomolecule translocation events. However, single-molecule sensing is challenging at extremely low analyte concentrations due to the limited flux of analytes to the sensing volume. This leads to a low event rate and increases the overall assay time. In this work, we present a method to enhance the event rate at low analyte concentrations by using isotachophoresis (ITP) to focus and deliver analytes to a nanopore sensor. Central to this method is a device capable of performing ITP focusing directly on a solid-state NP chip, while preventing the focusing electric field from damaging the nanopore membrane. We discuss considerations and trade-offs related to the design of the focusing channel, the ITP electrolyte system and electrical decoupling between the focusing and sensing modes. Finally, we demonstrate an integrated device wherein the concentration enhancement due to ITP focusing leads to an increase in event rate of >300-fold in the ITP-NP device as compared to the NP-only case.
Abnormal Grain Growth in Electrochemically Deposited Cu Films (2004)

Cu interconnects are essential in advanced integrated circuits to minimize the RC delay. In manufacturing these devices, Cu is deposited electrochemically using a plating bath containing organic additives. The as-deposited nanocrystalline Cu films undergo self-annealing at room temperature to form a micronsized grain structure by abnormal grain growth. Systematic experimental studies of self-annealing kinetics on model Cu films deposited on a Au substrate suggest that the rate of grain size evolution depends primarily on the initial grain size of the asdeposited film. A model for the observed abnormal grain growth process is proposed. Assuming that desorption of the organic additives leads to mobile grain boundaries, the onset of abnormal grain growth is attributed to a sufficiently low additive concentration such that a full coverage of all grain boundaries cannot be maintained. The incubation time of abnormal growth is then a logarithmic function of the initial grain size. The probability to find a growing grain is proportional to the number of grains per unit volume. This assumption is seen to be in good agreement with the experimental observations for subsequent abnormal grain growth rates. The limitations of the proposed model and the challenges to obtain further insight into the complex microstructure mechanisms during self-annealing are delineated.
Quantitative separation of electronic and steric substituent effects in reactions between aliphatic amines and electron acceptors (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTQuantitative separation of electronic and steric substituent effects in reactions between aliphatic amines and electron acceptorsChiyozo Takayama, Toshio Fujita, and Minoru NakajimaCite this: J. Org. Chem. 1979, 44, 16, 2871–2879Publication Date (Print):August 1, 1979Publication History Published online1 May 2002Published inissue 1 August 1979https://pubs.acs.org/doi/10.1021/jo01330a011https://doi.org/10.1021/jo01330a011research-articleACS PublicationsRequest reuse permissionsArticle Views98Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Aortic Valve Replacement in Infants and Children: Is the Ross and Ross-Konno Procedure an Ideal Long-term Treatment? (2018)

Objective: The term "left ventricular outflow tract obstructions" (LVOTO) in infants and children often summarizes a complex and heterogenic disease, requiring multilevel operations as well as interventional procedures necessitating aortic valve replacement including correction of LVOTO if other strategies fail.
American Clinical Neurophysiology Society Guideline 1: Minimum Technical Requirements for Performing Clinical Electroencephalography (2016)

2.1 ^*Recording electrodes should be free of inherent noise and drift.They should not significantly attenuate signals between 0.5 and 70 Hz.Experimental evidence suggests that silver-silver chloride or gold disk electrodes held on by collodion are the best, but other electrode materials and electrode pastes have been used effectively, especially with contemporary amplifiers having high input impedances.
FireDeX (2018)

Real-time event detection and targeted decision making for emerging mission-critical applications, e.g. smart fire fighting, requires systems that extract and process relevant data from connected IoT devices in the environment. In this paper, we propose FireDeX, a cross-layer middleware that facilitates timely and effective exchange of data for coordinating emergency response activities. FireDeX adopts a publish-subscribe data exchange paradigm with brokers at the network edge to manage prioritized delivery of mission-critical data from IoT sources to relevant subscribers. It incorporates parameters at the application, network, and middleware layers into a data exchange service that accurately estimates end-to-end performance metrics (e.g. delays, success rates). We design an extensible queueing theoretic model that abstracts these cross-layer interactions as a network of queues, thereby making it amenable for rapid analysis. We propose novel algorithms that utilize results of this analysis to tune data exchange configurations (event priorities and dropping policies) while meeting situational awareness requirements and resource constraints. FireDeX leverages Software-Defined Networking (SDN) methodologies to enforce these configurations in the IoT network infrastructure. We evaluate its performance through simulated experiments in a smart building fire response scenario. Our results demonstrate significant improvement to mission-critical data delivery under a variety of conditions. Our application-aware prioritization algorithm improves the value of exchanged information by 36% when compared with no prioritization; the addition of our network-aware drop rate policies improves this performance by 42% over priorities only and by 94% over no prioritization.
Photoresponsive Formation of Gold Particles in Silica/Titania Sol−Gel Films (1998)

Fine gold (Au) particles were formed by photochemical and thermal processes in silica/titania glassy films. Photoreduction and/or thermal gelation of films dip-coated from silica/titania precursor solutions including Au(III) ions yielded gold particles. Particle formation was accompanied by changes in the surface plasmon band. The size and morphology of the particles were affected by the titania content of the mixture matrix films as well as by the gelation temperature. With higher titania contents and at higher temperatures the particle formation was accelerated and accompanied by a red shift of the absorption band. This particle formation occurred by diffusion and reduction of the doped Au(III) ions, both of which were promoted at higher titania contents. The controllable photodeposition process enabled us to form micropatterns of Au particles by using photomasks.
Direct medical cost of pelvic inflammatory disease and its sequelae: decreasing, but still substantial (2000)

The direct medical cost of PID is still substantial. The majority of PID related costs are incurred in the treatment of acute PID. Because most PID-related costs arise in the first year from treatment of acute PID infection, strategies that prevent PID are likely to be cost-effective within a single year.
Arborizing tenascin network under the rapidly proliferating epithelium of epulis. (1993)

Free accessAbstractFirst published November 1993Arborizing tenascin network under the rapidly proliferating epithelium of epulis.R Adány, M Toida, and T TakamiView all authors and affiliationsVolume 41, Issue 11https://doi.org/10.1177/41.11.7691934
Characterization of a Novel Type of Serine/Threonine Kinase That Specifically Phosphorylates the Human Goodpasture Antigen (1999)

Goodpasture disease is an autoimmune disorder that occurs naturally only in humans. Also exclusive to humans is the phosphorylation process that targets the unique N-terminal region of the Goodpasture antigen. Here we report the molecular cloning of GPBP (Goodpasture antigen-binding protein), a previously unknown 624-residue polypeptide. Although the predicted sequence does not meet the conventional structural requirements for a protein kinase, its recombinant counterpart specifically binds to and phosphorylates the exclusive N-terminal region of the human Goodpasture antigen in vitro. This novel kinase is widely expressed in human tissues but shows preferential expression in the histological structures that are targets of common autoimmune responses. The work presented in this report highlights a novel gene to be explored in human autoimmunity.
Comparative Evaluation of a Full- and Partial-Power Processing Active Power Buffer for Ultracompact Single-Phase DC/AC Converter Systems (2020)

One of the key technical challenges of the Google and IEEE Little Box competition, an international contest to build the world's smallest 2-kW single-phase inverter in 2015, was to shrink the volume of the energy storage required to cope with the twice mains-frequency (120 Hz) pulsating power at the ac side and meet the stringent 2.5% input voltage ripple at the dc side. In this article, first, a full-power processing buck-type converter active buffer approach, selected by the first prize winner of the Little Box Challenge (LBC), is analyzed in detail. Being relieved from strict voltage ripple requirements, a larger voltage ripple is allowed across the buffer capacitor significantly reducing the capacitance requirement. Second, a partial-power active buffer approach, selected by the second prize winner of the LBC, where conventional passive capacitive buffering of the dc-link is combined with a series-connected auxiliary converter, used to compensate for the remaining 120-Hz voltage ripple across the dc-link capacitance, is studied in detail. In this article, both the selected concepts are comparatively evaluated in terms of achievable efficiency, power density, and ripple compensation performance under both stationary and transient conditions. Novel control schemes and optimally designed hardware prototypes for both considered buffer concepts are presented and accompanied by experimental measurements to support the claimed efficiency and power density and assess the performance of the implemented control systems. Finally, by means of comparison with conventional passive dc-link buffering using only electrolytic capacitors, it is determined at what voltage ripple requirement it actually becomes beneficial in terms of volume to employ the considered active buffer concepts.
Reconfigurable Terahertz Metamaterials (2009)

We demonstrate reconfigurable anisotropic metamaterials at terahertz frequencies where artificial "atoms" reorient within unit cells in response to an external stimulus. This is accomplished by fabricating planar arrays of split ring resonators on bimaterial cantilevers designed to bend out of plane in response to a thermal stimulus. We observe a marked tunability of the electric and magnetic response as the split ring resonators reorient within their unit cells. Our results demonstrate that adaptive metamaterials offer significant potential to realize novel electromagnetic functionality ranging from thermal detection to reconfigurable cloaks or absorbers.
A hybrid control approach to the Next-Best-View problem using stereo vision (2013)

In this paper, we consider the problem of precisely localizing a group of stationary targets using a single stereo camera mounted on a mobile robot. In particular, assuming that at least one pair of stereo images of the targets is available, we seek to determine where to move the stereo camera so that the localization uncertainty of the targets is minimized. We call this problem the Next-Best-View problem. The advantage of using a stereo camera is that, using triangulation, the two simultaneous images can yield range and bearing measurements of the targets, as well as their uncertainty. We use a Kalman filter to fuse location and uncertainty estimates as more measurements are acquired. Our solution to the Next-Best-View problem is to iteratively minimize the fused uncertainty of the targets' locations subject to field-of-view constraints. We capture these objectives by appropriate artificial potentials on the camera's relative frame and the global frame, respectively. In particular, with every new observation, the mobile stereo camera computes the new next best view on the relative frame and subsequently realizes this view in the global frame via gradient descent on the space of robot positions and orientations, until a new observation is made. Integration of next best view with motion planning results in a hybrid system, which we illustrate in computer simulations.
Drug Repurposing Against SARS-CoV-1, SARS-CoV-2 and MERS-CoV (2021)

Since the beginning of the COVID-19 pandemic, large <i>in silico</i> screening studies and numerous <i>in vitro</i> studies have assessed the antiviral activity of various drugs on SARS-CoV-2. In the context of health emergency, drug repurposing represents the most relevant strategy because of the reduced time for approval by international medicines agencies, the low cost of development and the well-known toxicity profile of such drugs. Herein, we aim to review drugs with <i>in vitro</i> antiviral activity against SARS-CoV-2, combined with molecular docking data and results from preliminary clinical studies. Finally, when considering all these previous findings, as well as the possibility of oral administration, 11 molecules consisting of nelfinavir, favipiravir, azithromycin, clofoctol, clofazimine, ivermectin, nitazoxanide, amodiaquine, heparin, chloroquine and hydroxychloroquine, show an interesting antiviral activity that could be exploited as possible drug candidates for COVID-19 treatment.
Performance Characterization and Optimization of Cement Systems for Thermally Stimulated Wells (2015)

Abstract Cement is critical to well integrity. It provides hydraulic isolation, preventing fluid flow between producing zones, ground water aquifers, and the surface. In steam stimulated wells, such as for Steam Assisted Gravity Drainage (SAGD) or Cyclic Steam Stimulation (CSS), the heat-up period places severe mechanical loading on the cement sheath. Heat is transferred from high temperature steam, through completion strings and annular fluids, to the casing, cement and formation. Thermal expansion of the casing combined with axial constraint make radial expansion of the casing the most severe in the energy industry. Furthermore, with constrained expansion of the cement, the range of deformations that must be accommodated by the cement sheath while maintaining isolation is challenging. These deformations can cause shear or tensile failure of the cement and result in leakage paths through the cement (e.g. cracks or global changes in cement permeability), or leave a micro-annulus when recovery has been completed and thermal operations halt. This paper describes the impact of key thermal and mechanical properties on the structural performance of cement blends in thermally stimulated wells. The work is based on laboratory testing of thermal cement blends and the use of Finite Element Analysis (FEA) to examine cement performance under operating conditions. The findings provide insight into important cement behaviours that impact longterm integrity of cement and highlight the significance of conducting tests under field representative conditions. Results indicate the importance of compressive strengths, flexibility, and shrinkage/expansion characteristics to ensure the cement sheath remains structurally intact during initial heat-up.