gebhart/patrepeval huggingface dataset:
Supplementary Table S2 from Development of Combination Strategies for Focal Adhesion Kinase Inhibition in Diffuse Gastric Cancer (2023)

&lt;p&gt;Drug List&lt;/p&gt;
Monolithically integrated resonator microoptic gyro on silica planar lightwave circuit (2000)

We report a novel configuration of resonator microoptic gyro (MOG), which is monolithically integrated on silica planar lightwave circuit (PLC) with countermeasures for noise factors. Optical ring-resonator gyros suffer mainly from polarization fluctuation induced noise and backscattering induced noise. We discuss eigenstate of polarization in the waveguide to clarify behavior of the former and propose a countermeasure with control of the waveguide birefringence. As for the latter, binary phase shift keying (B-PSK) with a special signal processing is proposed. Thermooptic (TO) phase modulation is the only one scheme to apply B-PSK in the silica waveguide, whose bandwidth is limited to /spl sim/1 KHz. To utilize the narrow bandwidth of the TO modulator effectively, we propose an electrical signal processing scheme and a modulation waveform to compensate the frequency response. By constructing an experimental setup, suppression of the backscattering induced noise is demonstrated, and the gyro output is observed with applying an equivalent rotation.
Chronic norepinephrine elicits desensitization by uncoupling the beta-receptor. (1989)

The goal of this study was to determine the mechanism of beta-adrenergic receptor desensitization after chronic elevation of circulating NE levels. Osmotic minipumps containing either NE or saline were implanted subcutaneously in dogs for 3-4 wk. Physiologic desensitization to isoproterenol was confirmed in conscious dogs, i.e., left ventricular dP/dt increased in response to isoproterenol (0.4 micrograms/kg per min) by 5,625 +/- 731 mmHg/s in control dogs with saline pumps, and significantly less, P less than 0.01, by 2,093 +/- 263 mmHg/s in dogs with NE pumps. Myocardial beta-adrenergic receptor density as determined with 125I-cyanopindolol binding was 49% higher (p less than 0.05) in the NE pump group. However, beta-adrenergic receptor agonist binding with isoproterenol demonstrated a significant shift into the low affinity state for the animals with NE pumps. Basal, GTP plus isoproterenol, 5'-guanylylimidodiphosphate, sodium fluoride, and forskolin-stimulated adenylate cyclase activity in the NE pump group were significantly depressed (P less than 0.05) by amounts ranging from 20 to 40%. The functional activity of the guanine nucleotide binding protein Gs was also reduced (P less than 0.05) in animals with NE pumps. Thus, the process of desensitization in response to chronic elevation of NE levels in intact, normal dogs does not involve a decrease in beta-adrenergic receptor density. Rather, it is characterized by reduced adenylate cyclase activation and uncoupling of the beta-adrenergic receptor in association with decreased activity of the GTP-coupling protein Gs.
Hepatic expression of the Sptlc3 subunit of serine palmitoyltransferase is associated with the development of hepatocellular carcinoma in a mouse model of nonalcoholic steatohepatitis (2015)

The molecular mechanisms underlying the progression of nonalcoholic steatohepatitis (NASH) have not been fully elucidated. The aim of this study was to identify factors involved in NASH progression by analysis of pathophysiological features and gene-expression profiles in livers of STAM mice, a model of NASH-associated hepatocarcinogenesis. C57BL/6N (B6N) mice were injected with streptozotocin to generate STAM mice. Four-week-old male STAM and B6N mice were fed a high-fat diet (HFD) (STAM-F, B6N-F) or a conventional diet (STAM-C, B6N-C) until they were 10, 14, or 18 weeks old. Blood glucose and nonalcoholic fatty liver disease (NAFLD) activity scores of STAM-F were higher than those of STAM-C during all observation periods. STAM-F mice had more severe hepatic fibrosis at 14 weeks, and exhibited higher levels of α-fetoprotein-positive hepatic tumor formation with multiplication than STAM-C mice at 18 weeks. At 14 weeks, cDNA microarray analysis revealed that the hepatic expression of eight mRNAs was ≥30-fold higher in STAM-F than B6N-F mice. The expression of another four genes was increased ≥5-fold in STAM-F than B6N-F mice, and ≥5-fold in B6N-F relative to B6N-C mice. Of the 12 genes, the difference in Sptlc3 mRNA expression was most pronounced, and gradually increased over time, as determined by quantitative RT-PCR in STAM-F mice. In addition, Sptlc3 mRNA expression in STAM-F mice was higher than that in db/db mice that received HFD and in B6N mice fed a choline‑deficient L-amino acid (CDAA)-defined diet. In conclusion, a high-fat diet aggravated pathophysiological findings in the liver in NASH mouse models, and the hepatic expression of Sptlc3 mRNA was potentially associated with NASH progression.
Catalytic Combustion of Gasified Coal for Low-Emissions Gas Turbines (2005)

In response to the Department of Energy’s (DOE) goals of developing low emission, coal-based power systems, Precision Combustion, Inc. is developing a low, single digit ppm NOx emissions system for high firing temperature IGCC systems. The present paper presents emissions data for syngas and alternate fuels tested successfully. Subscale testing results at 10 atmospheres include NOx emissions meeting DOE's target of 0.01 lbs/MMBtu (3 ppm at 15% O2) and were below this value under some operating conditions during parametric testing.
Système, information, média, Le SI comme objet des Sciences de l’information et de la communication (2009)

Résumé La notion de « système d’information » a été, en France, pensée par la communauté des informaticiens dans une perspective de rationalisation des systèmes de gestion des entreprises et organisations. Cela a conduit à une représentation relativement figée des relations entre les différents organes du SI, au détriment d’une réflexion, mieux ancrée dans les sciences de l’information et de la communication, et qui fait une meilleure place à la circulation des objets, des documents et de leurs représentations. L’article vise à montrer qu’en élargissant son espace et en saisissant de plus en plus l’activité du salarié dans toutes ses dimensions, le « SI » joue un rôle croissant de média.
Superior electrical properties of crystalline Er2O3 films epitaxially grown on Si substrates (2006)

Crystalline Er2O3 thin films were epitaxially grown on Si (001) substrates. The dielectric constant of the film with an equivalent oxide thickness of 2.0nm is 14.4. The leakage current density as small as 1.6×10−4A∕cm2 at a reversed bias voltage of −1V has been measured. Atomically sharp Er2O3∕Si interface, superior electrical properties, and good time stability of the Er2O3 thin film indicate that crystalline Er2O3 thin film can be an ideal candidate of future electronic devices.
The Synthesis of L-Leucyl-L-valyl-L-cysteinylglycyl- L-glutamyl-L-arginine, an Insulin Fragment with Strepogenin Activity1 (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Synthesis of L-Leucyl-L-valyl-L-cysteinylglycyl- L-glutamyl-L-arginine, an Insulin Fragment with Strepogenin Activity1George L. Tritsch and D. W. WoolleyCite this: J. Am. Chem. Soc. 1960, 82, 11, 2787–2793Publication Date (Print):June 1, 1960Publication History Published online1 May 2002Published inissue 1 June 1960https://pubs.acs.org/doi/10.1021/ja01496a031https://doi.org/10.1021/ja01496a031research-articleACS PublicationsRequest reuse permissionsArticle Views113Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A comparison of conventional radiography and computed tomography in the evaluation of spiral fractures of the tibia. (1985)

Spiral fractures of the distal third of the tibial shaft can have problems of malunion or non-union that may be related to inability to assess the quality of the initial reduction of the fracture. We created typical two-fragment torsional tibial fractures in cadaver bones. The fracture fragments were mounted in a specially constructed jig that allowed simulation of various malreduction positions including varus and valgus angulation, antecurvatum, recurvatum, malrotation, and shortening. Anteroposterior and lateral radiographs and computed tomographic scans of the specimens were made. Measurements of the fracture gap were made at defined distances along the fractures, directly on the specimens as well as on the radiographs and computed tomographic scans. Excellent correlation was obtained between measurements of the gap on the specimens and on the computed tomographic scans, but plain radiographic measurements in thirty of thirty-four instances underestimated the true width of the gap. When shortening was introduced larger maximum gaps (of as much as eighteen millimeters) as well as greater discrepancies between measurements on the scans and plain radiographs were seen. The sizes of the fracture gaps were also greater for a given degree of shortening when the pitch of the spiral fracture was greater.
Parameter re-estimation in semicontinuous hidden Markov modelling of speech with feedback to vector quantisation codebook (1988)

The parameters of the semicontinuous hidden Markov model (SCHMM) can be re-estimated by allowing the codebook to be updated, thus achieving an optimised codebook/model combination. With the optimised codebook, the SCHMM can offer improved recognition accuracy in comparison to both the continuous and the discrete hidden Markov model.
Chemokines in COPD (2007)

This chapter contains sections titled: CXC chemokines CC chemokines CX2C chemokines Therapeutic implications References
Inhibition of ribonucleotide reductase by 2'-substituted deoxycytidine analogs: possible application in AIDS treatment. (1994)

After phosphorylation to the corresponding diphosphates, 2'-azido-2'-deoxycytidine and 2'-difluorocytidine act as powerful inhibitors of ribonucleotide reductase. Phosphorylation requires deoxycytidine kinase, an enzyme with particularly high activity in lymphoid cells. Therefore, the deoxycytidine analogs can be expected to inhibit the reductase with some specificity for the lymphoid system. Pretreatment of human CEM lymphoblasts with the analogs considerably increased the phosphorylation of 3'-deoxy-3'-azidothymidine (AzT). The increased phosphorylation of AzT is caused by a prolongation of the S phase of the cell cycle. Our results suggest the possibility of a combination of 2'-substituted deoxycytidine analogs with AzT in the treatment of AIDS. Gao et al. [Gao, W.-Y., Cara, A., Gallo, R. C. & Lori, F. (1993) Proc. Natl. Acad. Sci. USA 90, 8925-8928] have suggested the use of the ribonucleotide reductase inhibitor hydroxyurea for this purpose, since the resulting decrease in the size of deoxyribonucleotide pools decreases the processivity of the HIV reverse transcriptase. From our results it would appear that the 2'-substituted deoxycytidine analogs might be preferable to hydroxyurea.
Dual-Polarization SAR Ship Target Recognition Based on Mini Hourglass Region Extraction and Dual-Channel Efficient Fusion Network (2021)

A novel Dual-polarization SAR ship target recognition method based on feature and loss fusion deep network is proposed in this paper, to improve the generalization ability, the recognition accuracy of imbalance samples, and the real-time performance of the general deep learning network. The proposed combined network is composed of two parts. The first part is the target region extraction network based on lightweight mini Hourglass network, to eliminate the impact of data imbalance and background noise on the identification accuracy. The second part is a two-channel feature/loss function fusion network based on Efficient B2 backbone network, aiming to solve the problem of dual-polarization image feature fusion and iterative convergence acceleration. The proposed method is tested on SAR image ship slices from the OpenSAR data sets. The experimental results indicates that, the proposed method achieves a recognition rate of 110FPS with recognition accuracy of 87.72%, and exceeds the SOTA by recognition accuracy 3.72% with convergence speed improved by 75.68%. The proposed method can be applied to SAR target recognition with dual polarization, imbalance samples and low-resolution condition for reference.
A parallel combinatory OFDM system (2002)

A parallel combinatory OFDM system (PC-OFDM) is proposed. The proposed system is able to obtain a higher bandwidth efficiency than an ordinary OFDM system. The bit error rate performance is analyzed and simulated. On a Gaussian channel and on known time invariant channels the PC-OFDM system can obtain lower bit error rates than ordinary OFDM. In some cases we can at the same time increase the bandwidth efficiency compared to an ordinary OFDM system. Further, the peak to mean power ratio of the PC-OFDM system is lower than for OFDM, which reduces the problem of designing linear power amplifiers.
A Fast Algorithm for Edge-Preserving Variational Multichannel Image Restoration (2009)

Variational models with $\ell_1$-norm based regularization, in particular total variation (TV) and its variants, have long been known to offer superior image restoration quality, but processing speed remained a bottleneck, preventing their widespread use in the practice of color image processing. In this paper, by extending the grayscale image deblurring algorithm proposed in [Y. Wang, J. Yang, W. Yin, and Y. Zhang, SIAM J. Imaging Sci., 1 (2008), pp. 248–272], we construct a simple and efficient algorithm for multichannel image deblurring and denoising, applicable to both within-channel and cross-channel blurs in the presence of additive Gaussian noise. The algorithm restores an image by minimizing an energy function consisting of an $\ell_2$-norm fidelity term and a regularization term that can be either TV, weighted TV, or regularization functions based on higher-order derivatives. Specifically, we use a multichannel extension of the classic TV regularizer (MTV) and derive our algorithm from an extended half-quadratic transform of Geman and Yang [IEEE Trans. Image Process., 4 (1995), pp. 932–946]. For three-channel color images, the per-iteration computation of this algorithm is dominated by six fast Fourier transforms. The convergence results in [Y. Wang, J. Yang, W. Yin, and Y. Zhang, SIAM J. Imaging Sci., 1 (2008), pp. 248–272] for single-channel images, including global convergence with a strong q-linear rate and finite convergence for some quantities, are extended to this algorithm. We present numerical results including images recovered from various types of blurs, comparisons between our results and those obtained from the deblurring functions in MATLAB's Image Processing Toolbox, as well as images recovered by our algorithm using weighted MTV and higher-order regularization. Our numerical results indicate that the processing speed, as attained by the proposed algorithm, of variational models with TV-like regularization can be made comparable to that of less sophisticated but widely used methods for color image restoration.
Parallel measurements of reaction kinetics using ultralow-volumes (2013)

We present a new platform for the production and manipulation of microfluidic droplets in view of measuring the evolution of a chemical reaction. Contrary to existing approaches, our device uses gradients of confinement to produce a single drop on demand and guide it to a pre-determined location. In this way, two nanoliter drops containing different reagents can be placed in contact and merged together, in order to trigger a chemical reaction. The reaction rate is extracted from an analysis of the observed reaction-diffusion front. We show that the results obtained using this platform are in excellent agreement with stopped-flow measurements, while decreasing the sample consumption 5000 fold. We also show how the device operation can be parallelized in order to react an initial sample with a range of compounds or concentrations, on a single integrated chip. This integrated chip thus further reduces sample consumption while reducing the time required for the experimental runs from hours to minutes.
Supplementary Figure Legends from Pulsed High-Intensity Focused Ultrasound Enhances Delivery of Doxorubicin in a Preclinical Model of Pancreatic Cancer (2023)

&lt;p&gt;Supplementary Figure Legends. Legends for Supplementary Figures S1-S2.&lt;/p&gt;
48. Cloning and characterisation of mouse GLUT12 in preimplantation embryos (2003)

Reproduction, Fertility and Development is an international journal publishing original research , review and comment in the fields of reproduction and developmental biology in humans, domestic animals and wildlife
Laser optoacoustic diagnostics of femtosecond filaments in air using wideband piezoelectric transducers (2016)

New opportunities in ultrasound diagnostics of femtosecond laser filaments with wideband piezoelectric transducers are considered. Transverse spatial resolution better than 100 microns is demonstrated in the single and regular multiple filamentation regime making path toward 3D filament tomography. The simple analytical model of the cylindrical acoustic source fitted well with the experimental data.
Antiretroviral protease inhibitors induce features of cellular senescence that are reversible upon drug removal (2022)

Antiretroviral drugs have dramatically improved the prognosis of HIV-infected patients, with strikingly reduced morbidity and mortality. However, long-term use can be associated with signs of premature aging. Highly active antiretroviral therapy generally comprises two nucleoside reverse transcriptase inhibitors (NRTIs), with one of three additional antiretroviral drug classes, including protease inhibitors (PIs). One commonality between mitochondrial dysfunction (induced by NRTIs) and defects in lamin A (induced by PIs) is they can cause or accelerate cellular senescence, a state of essentially irreversible growth arrest, and the secretion of many bioactive molecules collectively known as the senescence-associated secretory phenotype (SASP). We hypothesized that senescent cells increase following treatment with certain HIV therapies. We compared the effects of two distinct HIV PIs: ritonavir-boosted atazanavir (ATV/r) and ritonavir-boosted darunavir (DRN/r), used in combination treatments for HIV infection. Upon ATV/r, but not DRN/r, treatment, cells arrested growth, displayed multiple features of senescence, and expressed significantly upregulated levels of many SASP factors. Furthermore, mice receiving sustained ATV/r treatment showed an increase in senescent cells and age-related decline in physiological function. However, removing treatment reversed the features of senescence observed in vivo and cell culture. Given how these features disappeared with drug removal, certain features of senescence may not be prognostic as defined by an irreversible growth arrest. Importantly, for patients that are treated or have been treated with ATV/r, our data suggest that switching to another PI that does not promote premature aging conditions (DRN/r) may improve the associated age-related complications.
New tools for dissecting RON receptor tyrosine kinase oncogenic signaling (2006)

Commentary to:Agonistic Monoclonal Antibodies Potentiate Tumorigenic and Invasive Activities of Splicing Variant of the RON Receptor Tyrosine KinaseHang-Ping Yao, Yu-Lan Luo, Lei Feng, Lin-Fang Cheng, Yi Lu, Wei Li and Ming-Hai Wang
Oligoasthenospermia associated with multiple mitochondrial DNA rearrangements (1997)

A patient who wished to be treated for infertility by intracytoplasmic sperm injection (ICSI) was referred to our group for assessment. Upon clinical examination, a ptosis (partial closure of the eyelid) was noted, and histology revealed ragged red fibres in the skeletal muscle. Southern blot analysis of spermatozoa and skeletal muscle revealed the presence of multiple mitochondrial DNA deletions. This kind of rearrangement may be of nuclear origin since three nuclear loci have been ascribed to multiple mitochondrial DNA deletions in humans. Since mitochondrial DNA is maternally transmitted, the use of ICSI was feasible. However, an alteration of nuclear gene product affecting the integrity of mitochondrial DNA, and thus sperm mobility, might be transmitted to the offspring with the risk of developing a mitochondrial DNA disease.
Pharmacological approaches to preserving and restoring coronary endothelial function (2001)

There is compelling evidence that the endothelium is critical to normal coronary vascular function and that endothelial dysfunction, generally indicated by an impairment of endothelium-dependent vasodilatation, is an important component of coronary artery disease (CAD). Endothelial cells synthesise and release a number of factors, including prostacyclin, nitric oxide (NO), endothelium-derived hyperpolarising factor (EDHF) and endothelin, which are important in the regulation of vascular tone and the control of platelet and leukocyte adhesion, aggregation and migration. NO appears to be the critical factor in the preservation of normal coronary vascular function and there is a well-established correlation between CAD and an impairment of NO activity. Thus, to preserve endothelial function, drugs have been used to either increase the synthesis of NO, or to decrease its breakdown. Fortuitously, compounds such as the HMG-CoA reductase inhibitors, angiotensin (AT) converting enzyme inhibitors (ACEIs), AT receptor antagonists and oestrogen, which have been introduced into clinical practice because of other beneficial effects, have also been shown to improve coronary endothelial function through a variety of mechanisms. In addition, L -arginine, the substrate for NO synthesis, and the anti-oxidants ascorbate and alpha-tocopherol, are able to increase NO synthesis and bioavailability respectively. Studies in experimental animals strongly support the ability of these agents to enhance the activity of endothelium-derived NO but clinical trials have failed to demonstrate reversal of established CAD. Whether these agents preserve endothelial function and prevent the development of CAD remains to be established.
Electronic beam steering for passive millimeter-wave imaging (1998)

The long-term potential of terrestrial passive millimeter imaging is contingent upon demonstrating real-time imaging with a system that can be conveniently a deployed at an acceptable cost. For small apertures with modest resolution, imaging can be readily achieved using fully-staring focal plane arrays, but as in the infrared, the high cost per pixel means that scanning (preferably electronic) of a smaller number of detectors across the image is attractive. Aperture synthesis using sparse and filled arrays of antennas offers high sensitivity and resolution from a small number of antennas that can be conformal to vehicle shape, but requires complicated beam-forming technologies. Alteratively, electronic scanning can be accomplished by electronic modulation of a filled antenna. This paper will discuss novel approaches and technology requirements for achieving electronic beam-steering.