gebhart/patrepeval huggingface dataset:
Does escalation results from phase Ib/II Norse study of erdafitinib (ERDA) + PD-1 inhibitor JNJ-63723283 (Cetrelimab [CET]) in patients (pts) with metastatic or locally advanced urothelial carcinoma (mUC) and selected fibroblast growth factor receptor (FGFR) gene alterations. (2020)

511 Background: ERDA, an oral pan-FGFR inhibitor, is approved by the US FDA for pts with metastatic urothelial carcinoma (mUC) with susceptible FGFR3/2 gene alterations and progressed after ≥1 line of prior platinum-containing chemotherapy (PCC). 1 CET, an IgG4, binds to anti-programmed cell death proteins (PD-1) and has shown activity in solid tumors. 2 ERDA+CET may demonstrate complementary mechanisms as neoantigen release by ERDA may prime the tumor microenvironment for response. NORSE is a phase 1b/2 study to evaluate ERDA+CET in pts with mUC. Methods: Adult mUC pts with specific FGFR alterations who have progressed after ≥1 prior systemic therapy and no prior FGFR or PD-1/PD(L)-1 inhibitors enrolled in 3 dose levels (DL) of ERDA (DL1: 6 mg, DL2A: 8 mg, DL2: 8 mg with uptitration [UPT] to 9 mg) + CET (IV, 240 mg). Cohorts enrolled until dose limiting toxicity (DLT) or RP2D was identified. Primary endpoints: DLT and adverse events (AEs). Results: Of 15 pts (DL1: 4, DL2A: 3, DL2: 8), 11 continued on treatment at the time of the data cut. 14/15 pts experienced AEs; 3 experienced serious unrelated AEs (urinary tract infection, urosepsis, and large intestinal obstruction) all in DL1, 2 led to death; 10 experienced Grade &gt;3 AEs and 2 experienced AEs of special interest, considered related to ERDA (Table). No DLTs were observed in any cohorts, 8 mg with UPT + CET was established as the RP2D. At data cut-off, investigator-assessed best overall response rate (CR+PR+uCR+uPR) in pts treated with the RP2D was 71% and disease control rate was 100% for RECIST 1.1 evaluable pts (n=7). Conclusions: 8 mg ERDA with UPT+240 mg CET was well tolerated and established as the RP2D. The combination of ERDA+CET is being further explored in the ongoing randomized phase 2 study in first-line cisplatin-ineligible mUC pts (NCT03473743). Clinical trial information: 2017-001980-19. [Table: see text]
Two-minute heart rate recovery after cycle ergometer exercise and all-cause mortality in middle-aged men (2011)

A slow 2-min HRR after a cycle ergometer exercise test was an independent predictor of death in healthy middle-aged men after accounting for demographic and clinical characteristics. However, it was no longer predictive after accounting for chronotropic response and exercise capacity.
Thermodynamic stability and transformation of pharmaceutical polymorphs (2005)

Abstract The thermodynamic stability and transformation of pharmaceutical polymorphs was investigated, especially those of the thiazole derivative pharmaceutical, 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid (BPT). The influence of methanol compositions in solvents and temperature on the solubility and the transformation behavior of BPT was clarified. The transformation behavior was explained by the chemical potential difference between the stable and metastable forms. It was shown that a specific solute–solvent interaction contributes to the preferential nucleation and growth of the stable or metastable forms and influences the transformation behaviors. The solubility of BPT of the solvated crystals is much more influenced by the solvent compositions than the true polymorphs. The solubility ratio of the solvated crystals depends on the solvent composition, whereas the solubility ratio of the true polymorphs is considered to be independent of the solvents. The crystallization behavior was also investigated. The transformation rate after crystallization appeared to depend on the initial concentration of BPT and the addition rate of the antisolvent. The cause of this phenomenon was presumed to be a slight inclusion of the stable form in the metastable form.
How low will corn prices go (2015)

The recent dramatic decline in crop prices is a boon for livestock producers but a bust for crop producers, particularly for producers who just agreed to pay high rents. More generally, the tremendous volatility in all commodity markets makes it nearly impossible for producers and the food industry to plan for the future. But farmers need to begin planning for their 2009 crop, and food producers need to make procurement plans for the remainder of this marketing year. The type of plan that will be profi table depends on the answers to a number of key questions: Have we seen the end of high corn prices? Will prices continue to decline, and if so, how low will they go? Have we seen the end of the food versus fuel debate?
The application of biologically mediated leaching methods – A comprehensive review (2003)

The application of biologically assisted methods for metal extraction in the mining industry has a long history, but development of modern techniques has been relatively slow. There is, however, a resurgence of interest in the industry with the recent development of methods to successfully treat base metals concentrates. Two major pilot plant programs for treatment of chalcopyrite concentrates have been initiated in the past year and results from one are beginning to be released. This paper provides an overview of methods that have been applied in the past, from the earliest deliberate applications of this technology, through the copper and uranium heap and dump leach applications, the more highly engineered agitated tank leach gold applications, and the developments currently taking place in the industry.
The Viologen Cation Radical Pimer: A Case of Dispersion‐Driven Bonding (2017)

The π bonds between organic radicals have generated excitement as an orthogonal interaction for designing self-assembling architectures in water. A systematic investigation of the effect of the viologen cation radical structure on the strength and nature of the pimer bond is provided. A striking and unexpected feature of this π bond is that the bond strength is unchanged by substitution with electron-donating groups or withdrawing groups or with increased conjugation. Furthermore, the interaction is undiminished by sterically bulky N-alkyl groups. Theoretical modeling indicates that strong dispersion forces dominate the interaction between the radicals, rationalizing the insensitivity of the bonding interaction to substituents: The stacking of polarizable π radicals leads to attractive dispersion forces in excess of typical dispersion interactions of small molecules and helps overcome the Coulombic repulsion of bringing two cationic species into contact.
Involvement of 19-electron species in oxidatively induced homolytic metal-carbon bond cleavage reactions: decomposition of 17-electron cyclopentadienylruthenium methyl cations (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInvolvement of 19-electron species in oxidatively induced homolytic metal-carbon bond cleavage reactions: decomposition of 17-electron cyclopentadienylruthenium methyl cationsTorill Aase, Mats Tilset, and Vernon D. ParkerCite this: J. Am. Chem. Soc. 1990, 112, 12, 4974–4975Publication Date (Print):June 1, 1990Publication History Published online1 May 2002Published inissue 1 June 1990https://pubs.acs.org/doi/10.1021/ja00168a061https://doi.org/10.1021/ja00168a061research-articleACS PublicationsRequest reuse permissionsArticle Views145Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Thrombectomy with Conscious Sedation Compared with General Anesthesia: A DEFUSE 3 Analysis (2019)

Patients who underwent thrombectomy with conscious sedation in the extended time window experienced a higher likelihood of functional independence at 90 days, a lower NIHSS score at 24 hours, and a shorter time from femoral puncture to reperfusion compared with those who had general anesthesia. This effect remained robust in institutions that only treated patients with a single anesthesia technique.
Stroboscopic Schlieren system for the visual observation of pulsed ultrasonic waves (1964)

The purpose of this communication is to report our recent work employing a Schlieren optical system to make pulsed ultrasonic waves visible in water. The light source for the Schlieren system was a strobe lamp synchronized with the electrical pulses used to drive the ultrasonic transducer. Preliminary experiments described here have shown that a stroboscopic Schileren system has potential use as a nondestructive testing technique. Another possible use would be sound-velocity measurements in liquids and in solids immersed in a liquid.
Livestock-associated Methicillin-Susceptible Staphylococcus aureus ST398 Infection in Woman, Colombia (2011)

Livestockassociated Methicillin-Susceptible Staphylococcus aureus ST398 Infection in Woman, ColombiaTo the Editor: Staphylococcus aureus causes health care-and community-associated infections worldwide in humans and animals.It also asymptomatically colonizes a large proportion (20%-60%) of otherwise healthy individuals.In recent years, various countries have reported an increasing number of humans infected with livestock-associated S. aureus multilocus sequence type (ST) 398, which suggests that this strain is emerging in community and health care settings (1).Methicillinresistant S. aureus (MRSA) ST398 has received particular attention as a causative agent of infection in pigs, dogs, horses, cattle, and poultry.Colonization and infection in humans have also been described in Europe (2), Asia (3), Canada (4), and the United States (5), particularly among persons with frequent exposure to animals, such as farmers, veterinarians, and their household members.However, infections with MRSA ST398 and methicillin-susceptible S. aureus (MSSA) ST398 have recently been described in persons with no history of contact with livestock (6-10).We report infection of a woman with MSSA ST398 in Colombia, South America.On November 3, 2009, this 82-year-old woman was admitted to the emergency unit of the Hospital Universitario San Vicente Fundación in Medellín, reporting a 15-day history of fever, dyspnea, and pain in her left leg.She lived in a rural area and reported previous contact with dogs and chickens.Her medical history included diabetes mellitus,
Liver mevalonate 5-pyrophosphate decarboxylase is responsible for reduced serum cholesterol in stroke-prone spontaneously hypertensive rat. (1992)

Spontaneously hypertensive rat (stroke-prone) (SHRSP) has an interestingly low serum cholesterol level due to a reduced biosynthesis of cholesterol in the liver (Iritani, N., Fukuda, E., Nara, Y., and Yamori, Y. (1977) Atherosclerosis 28, 217-222). In this study, we examined the mechanism underlying the reduction of hepatic cholesterol biosynthesis in the rat. Our initial findings in SHRSP, as compared with normotensive Wistar Kyoto rat (WKY), showed that 1) the incorporation of [14C]acetate into cholesterol in the liver slices was markedly less, 2) 3-hydroxyl-3-methylglutaryl (HMG) CoA reductase activity was not reduced, and 3) the incorporation of [3H]mevalonic acid into both cholesterol and squalene was significantly less. The above initial findings suggested that the reduction in the hepatic cholesterol biosynthesis took place in one or more enzymatic processes starting with mevalonic acid and continuing to squalene. When the incorporation of [3H]mevalonic acid into phosphomevalonate derivatives was studied using an ion exchange column, only the radioactivity incorporated into isopentenyl-pyrophosphate (isopentenyl-PP) was less in SHRSP. Furthermore, the specific activity of diphosphomevalonate (mevalonate-PP) decarboxylase in the liver-soluble fractions was reduced 50% in SHRSP as compared with WKY. Kinetic studies using liver crude extracts indicated a lower Vmax value in SHRSP (SHRSP, 0.47; WKY, 2.05 nmol/min/mg), and an unchanged Km value (SHRSP, 18.2; WKY, 19.6 microM). The activity of mevalonate-PP decarboxylase was also found to be reduced in other tissues, including the brain, testis, small intestine, and cultured vascular smooth muscle cells. From the above observations, we concluded that the lower activity of mevalonate-PP decarboxylase was responsible for the reduced cholesterol biosynthesis in the liver of SHRSP.
Location-Aware Combinatorial Key Management Scheme for Clustered Sensor Networks (2006)

Recent advances in wireless sensor networks (WSNs) are fueling the interest in their application in a wide variety of sensitive settings such as battlefield surveillance, border control, and infrastructure protection. Data confidentiality and authenticity are critical in these settings. However, the wireless connectivity, the absence of physical protection, the close interaction between WSNs and their physical environment, and the unattended deployment of WSNs make them highly vulnerable to node capture as well as a wide range of network-level attacks. Moreover, the constrained energy, memory, and computational capabilities of the employed sensor nodes limit the adoption of security solutions designed for wire-line and wireless networks. In this paper, we focus on the management of encryption keys in large-scale clustered WSNs. We propose a novel distributed key management scheme based on exclusion basis systems (EBS); a combinatorial formulation of the group key management problem. Our scheme is termed SHELL because it is scalable, hierarchical, efficient, location-aware, and light-weight. Unlike most existing key management schemes for WSNs, SHELL supports rekeying and, thus, enhances network security and survivability against node capture. SHELL distributes key management functionality among multiple nodes and minimizes the memory and energy consumption through trading off the number of keys and rekeying messages. In addition, SHELL employs a novel key assignment scheme that reduces the potential of collusion among compromised sensor nodes by factoring the geographic location of nodes in key assignment. Simulation results demonstrate that SHELL significantly boosts the network resilience to attacks while conservatively consuming nodes' resources
Alkylating properties of phosphoramide mustard. (1976)

The relative alkylating activities of two of the cytotoxic metabolites of cyclophosphamide, phosphoramide mustard and nornitrogen mustard, have been studied at pH 4.6 and 7.4. The products formed on alkylation of ethanethiol by these metabolites have been identified, confirming that phosphoramide mustard undergoes alkylation reactions as an intact molecule. Deuterated analogs of the two metabolites have been synthesized, namely N,N-bis(2,2-dideutero-2-chloroethyl)-phosphorodiamidic acid and N,N-bis(2,2-dideutero-2-chloroethyl)amine and used to determine that alkylation proceeds directly via an aziridinium intermediate rather than a direct SN2 displacement of the chlorine atom.
Atonic Baggy Rectum and Sigmoid Syndrome (1997)

Objective.To improve the diagnosis and treatment for the syndrome of atonic baggy rectum and sigmoid.Methods:Four cases of atonic baggy rectum and sigmoid were reviewed.All patients were female and had a perineal anoplasty in infancy.Only one had postoperative anal stenosis.All had intractable constipation and soiling,and unresponsive to conservative treatment.A dilated atonic rectum and sigraoid was demonstrated by barium enema.The non-peristasis dilatated rectosigrnoid was found demarcated clearly from the normal bowel at operation.Histological examination revealed ganglion cells in all specimens.Results:Two had normal bowel movements after resection of the big bowel,one received a colostomy,and one remained soiling after swenson's resection.Conclusion:this syndrome is due to local dilatation of rectum and sigmoid,this abnormality is usually associated with anorectal and urogenital deformities.If conservative treatment is ineffective,the pathologic bowel should be resected.

Key words: 
Anus imperforate; Rectum; Sigmoid; Dilatation; pathologic
Intelligent scanning: Automated standard plane selection and biometric measurement of early gestational sac in routine ultrasound examination (2012)

IS of the GS from 2D real-time US is a practical, reproducible, and reliable approach.
Characterizing the vocalizations of North Atlantic right whales (NARWs) in Florida, with emphasis on mother-calf pairs (2011)

The repertoire of calls, frequency of occurrence with respect to social composition, and ontogeny of vocal learning is being investigated for NARWs in their southeastern critical habitat of Florida. Small synchronized, GPS-instrumented, digital autonomous recording packages (DARPs) are deployed in the vicinity of photo-identified individuals, mother-calf pairs, and groups. The unobtrusive DARP buoys enable the recording of relatively rare, low-intensity vocal exchanges between mothers and calves. We hypothesize that it may be advantageous to be silent or to call softly to avoid predators or harassment by males in the area. These mother-calf exchanges could also be related to early developmental aspects of vocal communication. Site-specific bathymetry and active propagation measurements are conducted with vertical arrays to estimate source levels, and ranges of detection. Preliminary data indicate that exemplar (up-calls) recorded in northern habitats and used for training detection algorithms for passive auto-detection buoys are likely not appropriate for Florida waters. Social demographics, associated behavior, along with water depth and environmental parameters contribute to differences in call rates, types, source levels and respective propagation characteristics between the southeastern and northern habitats. Critical acoustic data required for selecting more appropriate calls for effective DCL algorithms in Florida waters are currently being collected.
MP28-12 SUPPRESSION OF ONCOGENIC MICRORNA-1274A INDUCES CELL APOPTOSIS THROUGH BMPR1B ACCELERATION IN RENAL CELL CARCINOMA (2018)

INTRODUCTION AND OBJECTIVES: There is considerable evidence that normal microRNA (miRNA) regulatory mechanisms are disrupted in cancer cells. However, the regulatory mechanisms by which upregulated miRNAs exert their effects has not been often understood compared to downregulated miRNAs. Our previous studies of the miRNA expression signature in renal cell carcinoma (RCC) indicated that miR-1274a was significantly upregulated in clinical specimens, suggesting that miR-1274a might act as an oncogenic miRNA in RCC. The aim of this study was to investigate the functional roles of miR-1274a and identify downstream tumor suppressive targets regulated by miR-1274a in RCC cells.
Antioxidant Prenylated Flavonoids from Propolis Collected in Okinawa, Japan (2007)

Propolis is a resinous substance collected by honeybees from various plant sources. The composition of propolis depends upon the vegetation at the site of collection. We previously isolated four prenylated flavonoids from propolis collected in Okinawa, Japan. In this study, further fractionation of the extracts of Okinawan propolis resulted in the isolation of a new prenylated flavonoid, prokinawan, and four known compounds. The structure of prokinawan was determined by MS and NMR spectroscopic methods. Furthermore, the antioxidant activity using 1,1-diphenyl-2-picryl-hydrazyl radical scavenging and beta-carotene bleaching systems was investigated. The present study proved that the position of the geranyl or prenyl groups on the flavonoid skeleton plays an important role in exhibiting antioxidant activity.
Conclusion: the central role of human and social capital (2017)

The roles of human and social capital in fostering societal stability and progress are analyzed here in the basis of a series of empirical studies in the Asian region, each illuminating a separate aspect of the overall question: how does culture play a part in the socio-political economy? The studies cover the response of people in the Indonesian tourism industry to radical market changes; the impact of western-inspired management tools on workers in the Thai and Vietnamese industrial complexes; the ways in which credentials play a part in regional professional networking; the impact of worsening environment threats from flooding on workforce location and organizing; the not-always-benign workings of regional business networks of personal reciprocity; and the managerial ideology of many Indonesian companies. Human and social capital are illustrated here as largely invisible but still significant catalysts in the complex dynamics of countries striving to establish their own formulae for prosperity.
The Bu4NI-catalyzed alfa-acyloxylation of ketones with benzylic alcohols (2014)

The Bu4NI-catalyzed reaction of ketones with benzylic alcohols was achieved, leading to alfa-acyloxycarbonyl compounds in moderate to good yields. This metal-free procedure featured the employment of facilely and commercially available starting materials and TBHP as a clean oxidant with high atom economy.
The Loss of Limk1 Protects Endothelial Barrier Function (2006)

Restricted accessAbstractFirst published March 2006The Loss of Limk1 Protects Endothelial Barrier FunctionM. Gorovoy, R.F. Neamu, […], D. Predescu, and T. Voyno-Yasenetskaya+1-1View all authors and affiliationsVolume 54, Issue 2_supplhttps://doi.org/10.1177/108155890605402s61