gebhart/patrepeval huggingface dataset:
Overcoming Antigen Escape with CAR T-cell Therapy (2015)

Sotillo and colleagues describe the molecular events associated with apparent loss of target antigen expression following CAR T-cell therapy. We propose that broader immune activation is required to prevent outgrowth of tumor antigen escape variants following targeted therapies.
Polysulfide Exchange Reactions. I. Kinetics and Mechanism of the Thermal Exchange between Diethyl Trisulfide and Di-n-propyl Trisulfide (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolysulfide Exchange Reactions. I. Kinetics and Mechanism of the Thermal Exchange between Diethyl Trisulfide and Di-n-propyl TrisulfideC. D. Trivette Jr. and A. Y. CoranCite this: J. Org. Chem. 1966, 31, 1, 100–104Publication Date (Print):January 1, 1966Publication History Published online1 May 2002Published inissue 1 January 1966https://pubs.acs.org/doi/10.1021/jo01339a020https://doi.org/10.1021/jo01339a020research-articleACS PublicationsRequest reuse permissionsArticle Views236Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
In vitro plant regeneration from protocorms-like bodies (PLBs) and callus of Phalaenopsis gigantea (Epidendroideae: Orchidaceae) (2011)

Phalaenopsis, with long arching sprays of flowers, are among the most beautiful flowers in the world. Phalaenopsis is an important genus and one of the most popular epiphytic monopodial orchids, grown commercially for the production of cut flowers and potted plants. Most of them have different and interesting morphological characteristics which have different value to the breeders. Phalaenopsis gigantea is one of the most difficult to grow and has the potential of producing beautiful hybrids. An efficient and reproducible method for large-scale propagation of Ph. giganteausing leaf sections has been developed. Leaf sections from in vitro young plants were cultured on New Dogashima Medium (NDM) supplemented with cytokinins (6-Benzylaminopurine (BAP), Thidiazuron (TDZ), and Kinetin (KIN), each at 0.01, 0.1, 0.5 and 1.0 mg/L) alone and in combinations with (auxins a-naphthaleneacetic acid (NAA), at 0.01, 0.1, 0.5 and 1.0 mg/L). The explants developed calli and protocorm-like-bodies (PLBs) within 6 weeks of culture. Treatment TDZ in combination with auxins was found to be the best for the induction of callus and PLBs. In vitroregeneration of Ph. gigantea PLB was achieved by exposure to light and transferring to hormone free NDM solid medium.
Application of Electroextraction in Removing Copper from Molten Iron (2020)

An innovative attempt of applying electrochemical method in solving the residual copper challenge in iron and steel was proposed in this paper. The ionic conductivity of the sulfide slag has been found in study of copper removal from iron-based melt by Na2S–FeS system. A DC electric field was applied between sulfide melt and iron melt, which could electrolyze the product Cu2S, so that the activity of Cu2S in the sulfide slag was reduced and the selective sulfurization of copper in the iron was promoted. The cathodic process was studied by Voltammetry test and Potentiostatic electrolysis test, the results indicated that the Faradaic reactions indeed occurred and the directional mass transfer of copper was promoted by applying the electric field. In the results of copper removal test by electroextraction, the applied DC electric field broke the interface reaction equilibrium between sulfide slag and copper bearing carbon saturated iron melt and reduced the copper content significantly.
Load Balancing vs. Distributed Rate Limiting: An Unifying Framework for Cloud Control (2009)

With the expansion of cloud-based services, the question as to how to control usage of such large distributed systems has become increasingly important. Load balancing (LB), and recently proposed distributed rate limiting (DRL) have been used independently to reduce costs and to fairly allocate distributed resources. In this paper we propose a new mechanism for cloud control that unifies the use of LB and DRL: LB is used to minimize the associated costs and DRL makes sure that the resource allocation is fair. From an analytical standpoint, modelling the dynamics of DRL in dynamic workloads (resulting from LB cost-minimization scheme) is a challenging problem. Our theoretical analysis yields a condition that ensures convergence to the desired working regime. Analytical results are then validated empirically through several illustrative simulations. The closed- form nature of our result also allows simple design rules which, together with extremely low computational and communication overhead, makes the presented algorithm practical and easy to deploy.
Update on NIF Indirect Drive Ignition Target Fabrication Specifications (2004)

Indirect drive ignition target simulations are described as they are used to determine target fabrication specifications. Simulations are being used to explore options for making the targets more robust, and to develop more detailed understanding of the performance of a few point designs. The current array of targets is described. A new target is described with radially dependent Cu dopant in Be. This target has significantly looser specifications for high-mode perturbations than previous targets. Current estimates of size limitations for fill tubes, holes, and isolated defect are discussed. Recent 3D simulations are described.
Room-Temperature Ultraviolet Lasing from Zinc Oxide Microtubes (2003)

Prismatic zinc oxide microtubes have been fabricated by vapor transport. Room-temperature ultraviolet lasing action has been demonstrated in these microtube arrays. The ZnO microtubes, mainly appearing in tapped bell-mouthed shape, form natural laser cavities along the length direction. The hexagon diagonal and length of the microtube vary from 1 µm to 20 µm and 10 µm to a few hundred µm respectively. Under 355 nm optical excitation, lasing action is observed at room-temperature around 393 nm. Multi-longitudinal modes are also observed with significantly narrowed emission linewidth.
Comparison and Analysis of the Selection Mechanism in the Artificial Bee Colony Algorithm (2009)

Artificial bee colony (ABC) algorithm is a new global stochastic optimization algorithm based on the particular intelligent behavior of honeybee swarms, in which there exists many issues to be improved and solved. When onlooker bees exploit in ABC algorithm, they choose food source depending on the strategy of proportional selection that can result in the premature of the evolutionary process. In this paper, in order to improve the population diversity and avoid the premature, several selection strategies, such as disruptive selection strategy, tournament selection strategy and rank selection strategy, are compared and analyzed through simulation, and the results show that the modified algorithm outperforms the basic ABC algorithm.
Surface Characterization of Poly(ε-caprolactone)-Based Nanocomposites (2003)

This work deals with the preparation and the surface characterization of biodegradable nanocomposites made of poly(ε-caprolactone) (PCL) and a montmorillonite-type clay. Nanocomposites with different relative compositions of PCL and montmorillonite, either natural or organo-modified by various alkylammonium cations, are prepared by melt intercalation and in situ intercalative polymerization. The goal of this study is to characterize the dispersion of the clay layers in PCL, which is a critical parameter governing the final physical properties of the obtained nanocomposites. Morphological studies of PCL nanocomposites are carried out by means of scanning probe microscopy techniques while surface analysis is performed both by X-ray photoelectron spectroscopy and Fourier transform infrared spectroscopy. The results demonstrate that the dispersion of the clay layers is strongly dependent on both the synthetic route and the type of alkylammonium chains used for the cationic exchange. Whereas the melt-intercalation method leads to intercalated nanocomposites only after cationic exchange, the in situ polymerization method allows for reaching a much finer dispersion, even for the unmodified natural clay.
Experimental and theoretical investigation of the pixel saturation effect in digital holography (2011)

This paper presents an experimental investigation and an analytical modeling of the nonlinear pixel saturation effect in digital off-axis holography. The theoretical analysis is based on a semiempirical modeling and supported by the experimental analysis. Taking into account the nonlinearity of the phenomenon, an exponential law for the high-order harmonic amplitude is proposed and validated by the experimental results. The conclusion of this analysis is that the saturation effect can be described by the use of a linear operator that involves autoconvolution of the initial object wave, even though the saturation phenomenon is nonlinear.
Band pass current control (2002)

A current mode control technique for DC-DC converters using a band pass function in the current loop is described. This band pass current control circuit combines the low output impedance of voltage mode control with the advantages of peak current control into one simple, practical circuit implementation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Modeling Sensitization to Stimulants in Humans (2006)

Sensitization to stimulants can be achieved in healthy men in the laboratory. This phenomenon is associated with increased dopamine release and persists for at least 1 year.
Investigating the use of sensor-based IoET to facilitate learning for children in rural Thailand (2018)

A novel sensor-based Internet of Educational Things (IoET) platform named OBSY was iteratively designed, developed and evaluated to support education in rural regions in Thailand. To assess the effectiveness of this platform, a study was carried out at four primary schools located near the Thai northern border with 244 students and 8 teachers. Participants were asked to carry out three science-based learning activities and were measured for improvements in learning outcome and learning engagement. Overall, the results showed that students in the IoET group who had used OBSY to learn showed significantly higher learning outcome and had better learning engagement than those in the control condition. In addition, for those in the IoET group, there was no significant effect regarding gender, home location (Urban or Rural), age, prior experience with technology and ethnicity on learning outcome. For learning engagement, only age was found to influence interest/enjoyment. The study demonstrated the potential of IoET technologies in underprivileged area, through a co-design approach with teachers and students, taking into account the local contexts.
Simultaneous phase balancing at substations and switches with time-varying load patterns (2001)

This paper presents an algorithm for phase balancing of large-scale unbalanced radial distribution systems. The algorithm recommends rephasing of single- and double-phase laterals in order to improve circuit loss while also maintaining/improving imbalances at various balance point locations. Phase balancing calculations are based on circuit loss information and current magnitudes which are calculated from a power flow solution. The algorithm is designed to handle time varying loads when evaluating phase moves that will result in improved circuit losses over all load points. The proposed algorithm is heuristic in nature, and thus does not necessarily achieve the global minimum loss point. Example problems illustrating the algorithm are presented including a circuit that has 3894 components with 170 laterals.
Use of new reaction kinetics for COS formation to achieve reduced sulfur emissions from claus plants (1999)

Abstract A simulation study of COS formation in the tubes of the waste heat boiler (WHB) located just after the reaction furnace of a Claus plant is reported. First, the kinetics of the COS forming reaction were obtained from a recently completed experimental program in our laboratory. The predictions for COS formation from the newly developed kinetic model were compared with the data from an actual industrial waste heat boiler and found to be in good agreement. The simulation results showed that up to a 50% reduction in the COS production may be achieved by operating the WHB at the maximum allowable gas mass velocity in the WHB tubes coupled with the use of a smaller diameter tube. These reductions have major implications on the overall sulfur recovery from Claus plants.
IN VIVO FLUORESCENCE MICROSCOPY FOR THE ASSESSMENT OF MICROVASCULAR REPERFUSION INJURY IN SMALL BOWEL TRANSPLANTS IN RATS (1994)

With the use of in vivo fluorescence microscopy we have analyzed microvascular reperfusion injury of small bowel isograft transplants in rats. Following 1 hr cold storage in University of Wisconsin solution, the small bowel was transplanted heterotopically, and the intestinal microcirculation was quantitatively analyzed 20-60 min after onset of reperfusion. The intestinal grafts' capillary perfusion of both the mucosa and the circular and longitudinal muscles was not found altered when compared with the intestinal capillary perfusion of sham-operated controls. In contrast, leukocyte-endothelial cell interaction, including leukocyte rolling (40 +/- 5%) and sticking (280 +/- 100 mm-2) in submucosal postcapillary venules, was significantly increased when compared with nontransplanted controls (12 +/- 8% and 20 +/- 10 mm-2, P < 0.01 and P < 0.05, respectively). Leukocyte-endothelial cell interaction was associated with a marked alteration of lymphatic capillary drainage, as indicated by the low functional density of lymphatic microvessels of 10.2 +/- 6.1 cm-1 (P < 0.01 vs. sham-operated controls (39.2 +/- 6.1 cm-1)). From these results we propose that leukocyte-endothelial cell interaction, not capillary "no-reflow," is the primary step in the manifestation of microvascular reperfusion injury following a short period of cold ischemia in small bowel grafts.
Sintering of Tricalcium Phosphate by HIP (1989)

Tricalcium phosphate (TCP) was HIP'ed in a glass capsule at 800°-1100°C and 100MPa for 30min. Soda-lime glass was more suitable than Pyrex glass as a capsule material because of less thermal expansion mismatch from HIP-sintered TCP. Alumina powder was suitable as a barrier layer between glass capsule and sample, but boron nitride powder seemed to be reacted with the sample. The dense and transparent TCP ceramics were obtained by HIPing above 1000°C. In the comparison with pressureless sintering, the HIP treatment lowered the densification temperature as much as 200°C and also improved mechanical properties, 120MPa for bending strength and 0.8MPa·m1/2 for fracture toughness.
Boron-Fluorine Chemistry. I. Boron Monofluoride and Some Derivatives (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBoron-Fluorine Chemistry. I. Boron Monofluoride and Some DerivativesP. L. TimmsCite this: J. Am. Chem. Soc. 1967, 89, 7, 1629–1632Publication Date (Print):March 1, 1967Publication History Published online1 May 2002Published inissue 1 March 1967https://pubs.acs.org/doi/10.1021/ja00983a018https://doi.org/10.1021/ja00983a018research-articleACS PublicationsRequest reuse permissionsArticle Views1173Altmetric-Citations157LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Assessment of immediate and long-term functional results of percutaneous transluminal coronary angioplasty. (1988)

Assessment of the functional significance of coronary artery lesions during cardiac catheterization has recently become possible by calculating coronary flow reserve from both myocardial contrast appearance time and density in the resting and hyperemic states determined from digitized coronary cineangiograms. However, the interobserver and intraobserver variabilities, as well as the short-, medium-, and long-term variabilities of the coronary flow reserve measurements, have to be established before this technique becomes an acceptable means of assessing the immediate and long-term functional results of revascularization procedures such as percutaneous transluminal coronary angioplasty (PTCA). Variability was defined as the mean difference and standard deviation of the difference between duplicate determinations of coronary flow reserve. The intraobserver variability (mean difference +/- SD) in the measurement of coronary flow reserve was -0.01 +/- 0.07. Interobserver variability by two observers was +0.08 +/- 0.52. Short-term variability based on the analysis of two coronary cineangiograms taken 5 minutes apart was -0.02 +/- 0.26. Medium-term variability (coronary cineangiographies repeated 1-3 hours apart) was found to be -0.06 +/- 0.52. Long-term variability (coronary cineangiographies repeated 3-5 months apart) was 0.11 +/- 0.63. Having established the reproducibility of this radiographic method, we studied the prospective changes in coronary flow reserve in 25 patients undergoing PTCA for single vessel coronary artery disease. Coronary flow reserve measurements and quantitative coronary cineangiography were performed before, immediately after, and 3-5 months after PTCA. PTCA resulted in an immediate increase in coronary flow reserve from 1 +/- 0.3 to 2.3 +/- 0.6 with a concomitant increase in obstruction area from 0.9 +/- 0.3 to 3.3 +/- 0.7 mm2. Nine of the 25 patients developed restenosis defined as a diameter stenosis greater than 50% at follow-up. The other 16 patients had a coronary flow reserve of 3.3 +/- 0.6, which was measured 3-5 months after PTCA. Coronary flow reserve measurement from digitized coronary cineangiograms is a reproducible method for the assessment of the physiological importance of coronary artery obstructions. Short-, medium-, and long-term investigations of the functional results of interventions such as pharmacological therapy or revascularization can be performed reliably with this technique.
Patterned Monolayer/Polymer Films for Analysis of Dilute or Salt-Contaminated Protein Samples by MALDI-MS (2002)

This paper describes a surface science/mass spectrometry effort to develop and characterize a patterned gold surface that serves as a MALDI sample platform capable of concentrating and purifying proteins. Using microcontact printing, small (200-microm diameter) hydrophilic spots of bare gold or chemically anchored poly(acrylic acid) (PAA) are patterned at 5-mm intervals in a hydrophobic field consisting of a self-assembled monolayer of hexadecanethiol. Building on recent innovations by others, the small hydrophilic spots concentrate the sample to achieve good reproducibility and high sensitivity in the MALDI signal. One of the key features in this work is the combination of the high density of carboxylate groups in PAA with a small spot size to afford both concentration and purification of proteins via ionic interactions. This translates into detection limits for salt-contaminated proteins that are 20-100 times lower (low femtomole) than those reported for previous polymer- or monolayer-modified MALDI probes (using proteins in the 3-15-kDa range). Reflectance FT-IR spectroscopy and ellipsometry were used to determine the amount of protein adsorbed to a PAA-modified sample plate as a function of pH and salt concentration. Amide absorbances in IR spectra correlate well with MALDI-MS signals measured after addition of 2,5-dihydroxybenzoic acid as a matrix.
Survey Accuracy Analysis of a Hand-held Mobile LiDAR Device for Cultural Heritage Documentation (2016)

In this paper, the survey accuracy of a hand-held, GNSS-free mobile LiDAR device, the Zebedee, is studied by collecting measurements of several different geometric features in four different datasets. We use a new comprehensive accuracy assessment methodology based on geometric modelling which involves a geometric model of a prism/ pyramid for square structure. The point cloud accuracies of the features (planes, cylinders, catenaries, prisms and pyramids) were compared to that of a conventional survey-grade LiDAR system, the Leica ScanStation C10. The results suggested that the Zebedee accuracy is very comparable to the C10. For instance, the mean RMS error of plane fittings for the Zebedee is approximately 1.1 cm versus 0.6 cm for the C10. The estimated cylinder radii between the Zebedee and the C10 has only 1.4% difference in average, while the radii difference in prism/pyramid fitting is only 0.8%. As a result, the Zebedee LiDAR device is suitable for heritage mapping not only because it has high operation flexibility but also desired high accuracy.
Capillary-Channeled Polymer (C-CP) Fibers as a Stationary Phase for Sample Clean-Up of Protein Solutions for Matrix-Assisted Laser/Desorption Ionization Mass Spectrometry (2012)

Capillary-channeled polymer (C-CP) fibers are employed in a micropipette tip format to affect a stationary phase for the solid phase extraction (SPE) of proteins from buffer solutions prior to MALDI-MS analysis. Proteins readily adsorb to the polypropylene (PP) C-CP fibers while buffer species are easily washed off the tips using DI-H(2)O. Elution of the solutes is achieved with an aliquot of 50:50 ACN:H(2)O, which is compatible with the subsequent spotting on the MALDI target with the matrix solution. Lysozyme and cytochrome c are used as test species, with a primary buffer composition of 100 mM Tris-HCl. In this case, direct MALDI-MS produces no discernible protein signals. SPE on the C-CP fibers yields high fidelity mass spectra for 1 μL sample volumes. Limits of detection for cytochrome c in 100 mM Tris-HCl are on the order of 40 nM. Extraction of cytochrome c from buffer concentrations of up to 1 M Tris-HCl, provides signal recoveries that are suppressed by only ~50% versus neat protein solutions. Finally, extraction of 3.1 μM cytochrome c from a synthetic urine matrix exhibits excellent recovery.