gebhart/patrepeval huggingface dataset:
Essential role for Stat5a/b in myeloproliferative neoplasms induced by BCR-ABL1 and JAK2V617F in mice (2012)

STAT5 proteins are constitutively activated in malignant cells from many patients with leukemia, including the myeloproliferative neoplasms (MPNs) chronic myeloid leukemia (CML) and polycythemia vera (PV), but whether STAT5 is essential for the pathogenesis of these diseases is not known. In the present study, we used mice with a conditional null mutation in the Stat5a/b gene locus to determine the requirement for STAT5 in MPNs induced by BCR-ABL1 and JAK2(V617F) in retroviral transplantation models of CML and PV. Loss of one Stat5a/b allele resulted in a decrease in BCR-ABL1-induced CML-like MPN and the appearance of B-cell acute lymphoblastic leukemia, whereas complete deletion of Stat5a/b prevented the development of leukemia in primary recipients. However, BCR-ABL1 was expressed and active in Stat5-null leukemic stem cells, and Stat5 deletion did not prevent progression to lymphoid blast crisis or abolish established B-cell acute lymphoblastic leukemia. JAK2(V617F) failed to induce polycythemia in recipients after deletion of Stat5a/b, although the loss of STAT5 did not prevent the development of myelofibrosis. These results demonstrate that STAT5a/b is essential for the induction of CML-like leukemia by BCR-ABL1 and of polycythemia by JAK2(V617F), and validate STAT5a/b and the genes they regulate as targets for therapy in these MPNs.
ChemInform Abstract: Intramolecular Ring Formation of Phenyl Azide and Furan Moieties. (1982)

Abstract Die Azide (I) cyclisieren thermisch zu den Pyrrolochinolinen (II).
Tracking from one side (2019)

In this paper, we are interested in passively tracking multiple people walking in an area, using only the magnitude of WiFi signals from one WiFi transmitter and a small number of receivers (configured as an array) located on one side of the area. Past works on RF-based tracking either track only a single moving person, use a large number of transceivers surrounding the area to track multiple people, or use additional resources like ultra-wideband signals. Furthermore, magnitude-based tracking provides an attractive feature that additional receiver antennas can easily be added to the antenna array as needed, without the need for phase synchronization, since the magnitude can be measured independently on the different antennas. In this paper, we then propose a new framework that uses only the magnitude of WiFi signals and expresses it in terms of the angles of arrival of signal paths at the receivers as well as the motion parameters of the virtual arrays emulated by the moving people. We then use a two-dimensional MUltiple SIgnal Classification (MUSIC) algorithm to estimate the aforementioned parameters, and further utilize a Particle Filter with a Joint Probabilistic Data Association Filter to track multiple people walking in the area. We extensively validate our proposed framework in both indoor and outdoor areas, through 40 experiments of tracking 1 to 3 people, using only one transmit antenna and three laptops as receivers (a total of four off-the-shelf Intel 5300 WiFi Network Interface Cards (NICs)). Our results show highly accurate tracking (mean error of 38 cm in outdoor areas/closed parking lots, and 55 cm in indoor areas) using minimal WiFi resources on only one side of the area.
EM coupling in a composite component bay (2008)

In this paper, the shielding effectiveness of a composite component bay is simulated using both frequency domain and time domain methods. Five monitoring points are equally separated inside the component bay. Results gathered from measurements are compared to simulation results. The incident field is excited from different azimuth and elevation angles around the component bay in both simulations and measurements.
Detect-and-Track: Efficient Pose Estimation in Videos (2018)

This paper addresses the problem of estimating and tracking human body keypoints in complex, multi-person video. We propose an extremely lightweight yet highly effective approach that builds upon the latest advancements in human detection [17] and video understanding [5]. Our method operates in two-stages: keypoint estimation in frames or short clips, followed by lightweight tracking to generate keypoint predictions linked over the entire video. For frame-level pose estimation we experiment with Mask R-CNN, as well as our own proposed 3D extension of this model, which leverages temporal information over small clips to generate more robust frame predictions. We conduct extensive ablative experiments on the newly released multi-person video pose estimation benchmark, PoseTrack, to validate various design choices of our model. Our approach achieves an accuracy of 55.2% on the validation and 51.8% on the test set using the Multi-Object Tracking Accuracy (MOTA) metric, and achieves state of the art performance on the ICCV 2017 PoseTrack keypoint tracking challenge [1].
Comparisons of butyrylcholinesterase inhibitory potencies of selected 3-substituted-1-decylpiperidines with their electron charge densities (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTComparisons of butyrylcholinesterase inhibitory potencies of selected 3-substituted-1-decylpiperidines with their electron charge densitiesO. Elmo Millner Jr. and William P. PurcellCite this: J. Med. Chem. 1971, 14, 11, 1134–1136Publication Date (Print):November 1, 1971Publication History Published online1 May 2002Published inissue 1 November 1971https://pubs.acs.org/doi/10.1021/jm00293a038https://doi.org/10.1021/jm00293a038research-articleACS PublicationsRequest reuse permissionsArticle Views38Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
System level performance of UMTS-FDD with covariance transformation based DL beamforming (2004)

This paper presents a comparison of two different uplink to downlink covariance matrix transformation methods that can be used in downlink beamforming for frequency selective FDD channels. The performance improvement obtained from the transformation methods is compared with that from the method, which directly uses the uplink covariance matrix for downlink beamforming. For this purpose, a dynamic system level simulator developed for investigating the capacity improvement of a UMTS-FDD system employing smart antennas at the base stations is used. Downlink capacity is used as a measure of the performance of the system by finding the number of users for which a certain quality of service (QoS) requirement is fulfilled. System level simulations are carried out for antenna arrays with 2, 4 and 8 elements. Simulation results show that the downlink capacity can be improved significantly with higher number of antenna elements only if a transformation method is used in order to overcome the effect of different uplink and downlink carrier frequencies.
Risk factors for hepatic decompensation in patients with HIV/HCV coinfection and liver cirrhosis during interferon-based therapy (2004)

The results from APRICOT indicate that the overall risk of hepatic decompensation in HIV/HCV-coinfected patients without cirrhosis receiving IFN-based treatment is low. In contrast, patients with markers of advanced cirrhosis, despite the absence of a history of hepatic decompensation, should be monitored closely during IFN-based therapy, because they are at risk of hepatic decompensation. Treatment with antiretrovirals such as didanosine may increase the risk further.
Effect of microannuli on ultrasonic pulse-echo resonance and flexural Lamb-wave cement-evaluation measurements (2017)

In the oilfield industry, subterranean wells are constructed by placing steel tubes, so-called casings, inside the borehole and filling the space between casing and rock with cement. After the cement has cured, its proper placement is often verified through ultrasonic measurements (such as modes exploiting the casing thickness resonance or flexural/extensional Lamb waves) from the accessible interior of the casing. Because of environmental effects such as cement shrinkage or changes in static pressure, the mechanical bond between casing and cement can be altered with significant effects on the acoustic measurement response. The casing-to-cement interface can open a gap, a so-called microannulus, measuring in thickness from submicrons to hundreds of microns and filled with either gas or liquid. A direct and unambiguous characterization of these microannuli through an ultrasonic measurement is rendered difficult due to the subwavelength dimensions of the microannuli. We have studied the experimental signature of ultrasonic pulse-echo thickness resonances and flexural Lamb waves for liquid-filled microannuli for various annulus materials and steel casing thicknesses. This characterization enables us to statistically link measurement results to microannulus thicknesses. For the highest-precision measurements, we used in-situ laser interferometry to characterize the exact microannulus thickness through transparent annulus samples.
Non-invasive monitoring of eating behavior using spectrogram analysis in a wearable necklace (2014)

Food intake levels, hydration, chewing and swallowing rate, and dietary choices are all factors known to impact one's health. This paper presents a novel wearable system in the form of a necklace, which aggregates data from an embedded piezoelectric sensor capable of detecting skin motion in the lower trachea during ingestion. We propose an algorithm based on spectrogram analysis of piezoelectric sensor signals to accurately distinguish between food types such as liquid and solid, hot and cold drinks and hard and soft foods. The necklace transmits data to a smartphone, which performs the processing of the signals, classifies the food type, and provides visual feedback to the user to assist the user in monitoring their eating habits over time. Experimental results demonstrate high classification accuracy of the proposed method, and validate the use of a spectrogram in extracting key features representative of the unique swallow patterns of various foods.
Four-Dimensional Computed Tomography–Guided Valve Sizing for Transcatheter Pulmonary Valve Replacement (2022)

Background: Measurements of the right ventricle and pulmonary artery are highly variable for the optimal selection of prosthesis size of transcatheter pulmonary valve replacement, (TPVR). Traditional measurement methods by 2D/3D imaging for device size prediction are insufficient to assess the displacement of the right ventricular outflow tract and pulmonary artery which could increase the risks of stent misplacement, paravalvular leak, and device embolization. We aim to provide a dynamic model to visualize and quantify the anatomical structure of the RVOT to PA over the entire cardiac cycle with 4D cardiac CT reconstruction to achieve an accurate quantitate evaluation of needed valve size.
Supplementary Figure 2 from Prostate Cancer Progression Correlates with Increased Humoral Immune Response to a Human Endogenous Retrovirus GAG Protein (2023)

&lt;p&gt;- PDF file 341K, qPCR gene expression analysis of chromosome 22q11.23 region in cancer tissues. Total RNA from cancer tissues was submitted to DNAse treatment and reverse transcriptase reaction for cDNA synthesis. The resulting cDNA was used on qPCR to detect the expression of GAG-HERV-K and the neighbor genes BCR, IGGL1, RGL4 and ZDHHC8P. The results are expressed as relative expression to GAG-HERV-K levels in normal prostate. GAG-HERV-K expression is relative to GAPDH. BCR, IGGL1, RGL4 and ZDHHC8P expression is relative to TFRC&lt;/p&gt;
A fast algorithm for the nearest-neighbor classifier (1997)

A fast algorithm that finds the nearest neighbor (NN) of an unknown sample from a design set of labeled samples is proposed. This algorithm requires a quite moderate preprocessing effort and a rather excessive storage, but it accomplishes substantial computational savings during classification. The performance of the algorithm is described and compared to the performance of the conventional one. Results on simulated data are provided to illustrate the computational savings that may be achieved using this fast algorithm.
Resilient reduced-state resource reservation (2005)

Due to the strict requirements of emerging applications, per-flow admission control is gaining increasing importance. One way to implement per-flow admission control is using an on-path resource reservation protocol, where the admission decision is made hop-by-hop after a new flow request arrives at the network boundary. The next-steps in signaling (NSIS) working group of the Internet engineering task force (IETF) is standardising such an on-path signaling protocol. One of the reservation methods considered by NSIS is reduced-state mode, which, suiting the differentiated service (DiffServ) concept, only allows per-class states in interior nodes of a domain. Although there are clear benefits of not dealing with per-flow states in interior nodes — like scalability and low complexity —, without per-flow states the handling of re-routed flows, e.g., after a failure, is a demanding and highly non-trivial task. To be applied in carrier-grade networks, the protocol needs to be resilient in this situation. In this article, we will explain the consequences of a route failover to resource reservation protocols: Severe congestion and incorrect admission decisions due to outdated reservation states. We will set requirements that handling solutions need to fulfill, and we propose extensions to reduced-state protocols accordingly. We show with a set of simulated scenarios that with the given solutions reduced-state protocols can handle re-routed flows practically as fast and robust as stateful protocols.
What is the Best Engineering Ethics Education? (2021)

Currently, engineering ethics education is mandated for engineering students. Department of Mechanical Engineering at Keio University offers a lecture called “Souzou to Rinri (Innovation and Ethics) ” to junior students. In this manuscript, the author discusses what the engineering ethics and its education are, based on the knowledge and experiences through the lecture for years. Ethics problems do not have correct answers and are not subject to be taught. The students need to be educated by themselves through actively discussing the problems. As new technologies emerge, ethics need to be not only discussed but also practiced in the real world at a good speed to match the demand from society. In addition, new boundary conditions, such as COVID-19, need to be considered. These may lead to a new domain of ethics.
Data from Cullin 1 Functions as a Centrosomal Suppressor of Centriole Multiplication by Regulating Polo-like Kinase 4 Protein Levels (2023)

&lt;div&gt;Abstract&lt;p&gt;Abnormal centrosome and centriole numbers are frequently detected in tumor cells where they can contribute to mitotic aberrations that cause chromosome missegregation and aneuploidy. The molecular mechanisms of centriole overduplication in malignant cells, however, are poorly characterized. Here, we show that the core SKP1-cullin-F-box component cullin 1 (CUL1) localizes to maternal centrioles and that CUL1 is critical for suppressing centriole overduplication through multiplication, a recently discovered mechanism whereby multiple daughter centrioles form concurrently at single maternal centrioles. We found that this activity of CUL1 involves the degradation of Polo-like kinase 4 (PLK4) at maternal centrioles. PLK4 is required for centriole duplication and strongly stimulates centriole multiplication when aberrantly expressed. We found that CUL1 is critical for the degradation of active PLK4 following deregulation of cyclin E/cyclin-dependent kinase 2 activity, as is frequently observed in human cancer cells, as well as for baseline PLK4 protein stability. Collectively, our results suggest that CUL1 may function as a tumor suppressor by regulating PLK4 protein levels and thereby restraining excessive daughter centriole formation at maternal centrioles. [Cancer Res 2009;69(16):6668–75]&lt;/p&gt;&lt;/div&gt;
Studies on the acute release of tissue-type plasminogen activator from human endothelial cells in vitro and in rats in vivo: evidence for a dynamic storage pool (1995)

The process of acute release of tissue-type plasminogen activator (tPA) is important in locally speeding up fibrinolysis. Using a sensitive enzyme-linked immunosorbent assay for tPA, we investigated the acute release of tPA from cultured human umbilical vein endothelial cells. The addition of thrombin (0.003 to 3 NIH U/mL) caused the dose-dependent release of noncomplexed, enzymatically active tPA into the medium. The amount of tPA released into the medium by thrombin was similar to the difference in the amounts of tPA present in extracts from thrombin-treated cells and control cells. The process of acute release of tPA was complete in 1 minute, whereas the concomitant release of von Willebrand factor into the medium was slightly slower (maximum after 3 minutes). By increasing (c.q. decreasing) tPA synthesis, it was found that the amount of tPA constitutively secreted, the amount acutely released, and the amount in cell extracts were increased (c.q. decreased) to the same extent. The same relation was found in vivo. When rats were pretreated with cholera toxin or retinoic acid to increase tPA synthesis, plasma levels of tPA were increased, whereas acute release of tPA, as induced by bradykinin, was increased to the same extent. Acutely released tPA and constitutively secreted tPA were liberated from different pathways in human umbilical vein endothelial cells; tPA had, relative to the in vivo situation, a short residence time in the acutely releasable pathway.
Controlled Impedance Test Apparatus for Studying Human Interpretation of Kinesthetic Feedback (1989)

Many feedback control systems, especially those for complex applications, involve humans in the control loop. Visual information traditionally has been presented to human controllers who make manual responses (i.e., via keyboard, joystick, or other interfaces). To expand system bandwidth, other information channels can be presented so human operators. Kinesthesis, the perception of body positions and forces, represents an attractive supplementary form of human-machine communication, since the limbs (e.g., an operator's hand) can be used both for input and output of information in the control loop. Although psychophysical studies have measured perception of isolated mechanical properties, limited work has been conducted to study human kinesthetic abilities in the context of control. The research described here assesses judgement of coupled properties, including the superposition of linear stiffness, damping, and inertia. Quantitative perception of these properties may depend upon correct models of the mechanical system with which a user interacts. Similarly, perception of fundamental mechanical properties may be influenced by system delays (on the order of magnitude of human reaction time). This paper describes both an apparatus for understanding kinesthetic interaction with mechanical systems and an approach for studying human perception of mechanical properties.
Touch of the conductor with earth surface in resonant earthed medium voltage systems (2013)

This paper evaluates the behaviour of physical quantities in the case when electrical conductor under normal operation comes in touch with the earth surface. The main aim of the paper is to perform extensive field-testing and measurement in order to get better insight into phenomena that appear at the place of fault. The newly developed equipment and procedures, required to perform the tests, are presented together with the obtained results.
Tunable liquid crystal Fabry-Perot filters (2003)

In this paper tuneable optical filters based on liquid crystal Fabry-Perot interferometers (LCFPI) are presented. Liquid crystal (LC) devices are lightweight and suitable for compact arrays with a large number of pixels, as shown in high resolution flat panel displays. The fabricated filters offer a high finesse (119) and a wide tuning range. The devices are coupled to standard single mode fibers by fiber collimators. For all filters the layer structure of a standard passive LC display is used, adding only two reflective layers. Dielectric mirrors (R = 0.98) are used to achieve high finesse and low insertion losses (-4.8 dB). The cost can be further reduced by using thin gold layers, acting as electrodes and mirrors (R = 0.9) at the same time. The finesse of the Gold-FPIs is about 30 and the measured insertion loss is -10 dB. Additionally, a twisted nematic (TN) structure is investigated. Using this orientation, the polarization dependence of the device is reduced with increasing tuning voltage.
A Bio‐synthetic Hybrid Hydrogel Formed under Physiological Conditions Consisting of Mucin and a Synthetic Polymer Carrying Boronic Acid (2022)

Mucin-containing bio-synthetic hybrid hydrogel is successfully formed under physiological conditions upon mixing aqueous solutions of native mucin and synthetic polymers carrying boronic acids. The mechanical properties and stability of the hydrogel in physiological solutions, e.g., cell culture media, are tunable depending on the boronic acid content of polymers. The hydrogel dissolved in the physiological solutions releases native mucin and boronic acid-containing polymer, which can control the adhesion of mammalian cells to the surface.
Acetylene as a suicide substrate and active site probe for methane monooxygenase from Methylococcus capsulatus (Bath) (1985)

Acetylene was shown to be an inhibitor of cell-free methane monooxygenase (MMO) activity in Methylococcus capsulatus (Bath). Inhibition was demonstrated for both the soluble and particulate forms of the enzyme and was dependent on the presence of both NADH and oxygen. Inactivation of the enzyme complex was irreversible and was due to binding of the acetylene to specific proteins of the enzyme complex. The use of radiolabelled [14C]acetylene provided a method for visualisation of the bound inhibitor: protein complex on sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis (PAGE). Acetylene was shown to bind to proteins which are associated with methane-oxidising activity and it is proposed that acetylene acts as a suicide substrate.