gebhart/patrepeval huggingface dataset:
Increased unilateral tendon stiffness and its effect on gait 2–6 years after Achilles tendon rupture (2015)

Achilles tendon rupture (ATR) alters tissue composition, which may affect long-term tendon mechanics and ankle function during movement. However, a relationship between Achilles tendon (AT) properties and ankle joint function during gait remains unclear. The primary hypotheses were that (a) post-ATR tendon stiffness and length differ from the noninjured contralateral side and that (b) intra-patient asymmetries in AT properties correlate to ankle function asymmetries during gait, determined by ankle angles and moments. Ultrasonography and dynamometry were used to assess AT tendon stiffness, strain, elongation, and rest length in both limbs of 20 ATR patients 2-6 years after repair. Three-dimensional ankle angles and moments were determined using gait analysis. Injured tendons exhibited increased stiffness, rest length, and altered kinematics, with higher dorsiflexion and eversion, and lower plantarflexion and inversion. Intra-patient tendon stiffness and tendon length ratios were negatively correlated to intra-patient ratios of the maximum plantarflexion moment and maximum dorsiflexion angle, respectively. These results suggest that after surgical ATR repair, higher AT stiffness, but not a longer AT, may contribute to deficits in plantarflexion moment generation. These data further support the claim that post-ATR tendon regeneration results in the production of a tissue that is functionally different than noninjured tendon.
Effect of heat treatment on the structure and properties of a high-nitrogen austenitic corrosion-resistant 03Kh20AG11N7M2 steel (2010)

The structure and mechanical and corrosion properties of a high-strength austenitic 03Kh20AG11N7M2 steel after quenching and aging at 500 and 800°C are analyzed. The phase composition of the steel and the mechanism of the decomposition of austenite during heat treatment are studied by electron-probe microanalysis and transmission electron microscopy. This steel is thermally stable upon heating to 800°C for 1 h and is stable to the γ → α and γ → ɛ martensitic transformation during deformation up to tensile strains leading to fracture. The homogeneous decomposition of a supersaturated γ solid solution at 500°C leads to the formation of disperse CrN nitrides, which increase the strength of the steel and insignificantly decrease its plasticity. In this case, the stress corrosion cracking resistance slightly decreases and the passivation of the steel increases in an corrosive medium without loading.
Evolution of RNA-binding Specificity in T4 DNA Polymerase (1997)

DNA polymerase of phage T4 (T4 gp43), an essential component of the T4 DNA replicase, is a multifunctional single-chained (898-amino acid) protein that catalyzes the highly accurate synthesis of DNA in phage replication. The enzyme functions both as a DNA-binding replication protein and as a sequence-specific RNA-binding autogenous translational repressor. We have utilized a phylogenetic approach to study the relationships between the two nucleic acid-binding functions of the protein. We found that autogenous translational control of gp43 biosynthesis has been conserved in phage RB69, a distant relative of T4, although we also found that the RB69 system differs from its T4 counterpart in two regards: (a) nucleotide sequence and predicted secondary structure of the RNA target (translational operator), and (b) RNA specificity of the protein. T4 gp43 is specific to the RNA operator sequence of the T4 genome whereas RB69 gp43 can bind and repress operator RNA from both phages equally well. In studies with T4-RB69 gp43 chimeras, we mapped T4 gp43 RNA-binding specificity to a protein segment that also harbors important determinants for DNA binding and the polymerase catalytic function. Our results suggest that RNA functions as a regulator of both the dosage and activity of this DNA replication enzyme.
Synthesis, Cytotoxicity and Pro-apoptosis of Novel Benzoisoindolin Hydrazones as Anticancer Agents (2010)

A series of benzoisoindolin hydrazones as analogues of natural lignan diphyllin were synthesized and the structures of these compounds were established by (1)H-NMR, (13)C-NMR, Mass and high resolution (HR)-MS. The compounds were evaluated for in vitro cytotoxicity against KB, A549 and HCT-116 cancer cell lines by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Compound 4 possessed the highest growth inhibitory effect. Significant apoptosis of HCT-116 cells treated with compound 4 was observed by Hoechst33342-propidium iodide (PI) and acridine orange (AO)-ethidium bromide (EB) staining assay. Western blot analysis disclosed that compound 4 induced apoptosis via the mitochondrial pathway accompanied by an increased expression of Bax and a decreased expression of Bcl-2.
A study on factor influencing purchase intention of smartphone among university students in Melaka / Muhammad Zul Fathi Mohd Zulkifli (2020)

Smartphone is one of technology device that common use for many peoples in their daily life. This technology is very useful for their users to do several of activities in anytime and everywhere. Therefore, smartphone is one of platform that has side effect of good and bad for people which is it can show on how people use the smartphone. Some of good side is the user use the smartphone to have a communication with others, education and online learning while for bad side, the user use to do some illegal activities like fraud, scam, hacked and others. 
The purpose of this thesis is to know which factors is more influencing purchase intention of smartphone among university students. The most factors influence purchase intention of smartphone will help student to make a choice based on their preference. Other than that, the demand of smartphone will increase if the most influential will contribute to their chosen. 
The method used in this study is regression analysis which is it will explain on what factors will show significant or not significant. The techniques used to collect the data is by distribute a questionnaire to the target population that will more explain in Chapter 3. In this report, it will show the output of result to identify the most factors influencing purchase intention of smartphone among university students.
Risk Factors Leading to Failed Procedural Sedation in Children Outside the Operating Room (2014)

Presence of a URI, a history of OSA/snoring, ASA class III, obesity, and older age are associated with increased probability of failed sedation. A prospective, multicenter observational study would allow for the robust modeling of comorbidities to guide pediatric sedation management.
Enteral tranexamic acid attenuates vasopressor resistance and changes in α1-adrenergic receptor expression in hemorrhagic shock (2017)

Results from this study demonstrate that experimental hemorrhagic shock leads to decreased response to the α1-selective agonist phenylephrine and decreased α1 receptor density via circulating shock factors. These changes are mitigated by enteral TXA with correspondingly improved hemodynamics. Proteolytic inhibition in the lumen of the small intestine improves hemodynamics in hemorrhagic shock, possibly by restoring α1 adrenergic functionality necessary to maintain systemic blood pressure and perfusion.
Myocardial calcium-independent nitric oxide synthase activity is present in dilated cardiomyopathy, myocarditis, and postpartum cardiomyopathy but not in ischaemic or valvar heart disease. (1995)

These results support the hypothesis the generation of nitric oxide by iNOS accounts for some of the dilatation and impaired contractility associated with inflammatory and non-inflammatory dilated cardiomyopathy and peripartum cardiomyopathy.
Technical advances in transjugular intrahepatic portosystemic shunts. (1992)

A transjugular intrahepatic portosystemic shunt (TIPS) can be created percutaneously with the Palmaz balloon-expandable stent. This article describes a transjugular-only approach with a 16-gauge needle. A functional and efficacious shunt can be achieved in most cases with stent diameters of 8-10 mm. Occasionally, a 12-mm-diameter shunt is necessary for effective variceal decompression. The procedure is considered successful when the portosystemic gradient is lowered to 12 mm Hg or less after stent placement. Hepatic vein stenosis in the shunt outflow can develop after the TIPs procedure. This complication has been treated successfully with additional stent placement. TIPS can undoubtedly be performed successfully and safely with a transjugular-only approach; however, the full impact of TIPS on the treatment of portal hypertension remains to be determined.
A specific gene-microbe interaction drives the development of Crohn’s disease–like colitis in mice (2019)

Bacterial dysbiosis is associated with Crohn's disease (CD), a chronic intestinal inflammatory disorder thought to result from an abnormal immune response against intestinal bacteria in genetically susceptible individuals. However, it is unclear whether dysbiosis is a cause or consequence of intestinal inflammation and whether overall dysbiosis or specific bacteria trigger the disease. Here, we show that the combined deficiency of NOD2 and phagocyte NADPH oxidase, two CD susceptibility genes, triggers early-onset spontaneous T<sub>H</sub>1-type intestinal inflammation in mice with the pathological hallmarks of CD. Disease was induced by <i>Mucispirillum schaedleri</i>, a Gram-negative mucus-dwelling anaerobe. NOD2 and CYBB deficiencies led to marked accumulation of <i>Mucispirillum</i>, which was associated with impaired neutrophil recruitment and killing of the bacterium by luminal neutrophils. Maternal immunoglobulins against <i>Mucispirillum</i> protected mutant mice from disease during breastfeeding. Our results indicate that a specific intestinal microbe triggers CD-like disease in the presence of impaired clearance of the bacterium by innate immunity.
Pharmacokinetics and Tolerability of Rabeprazole in Children 1 to 11 Years Old With Gastroesophageal Reflux Disease (2011)

Palatability of the formulation was reported to be good or excellent. Rabeprazole was well tolerated, with no notable differences in safety among the dose groups.
A SiC CMOS Linear Voltage Regulator for High-Temperature Applications (2019)

This paper establishes the first integrated silicon carbide (SiC) CMOS linear voltage regulator. The design provides for a continuous load current exceeding 100 mA and a 15 V output from an input voltage of 20 to 30 V. The foundation of the regulator's feedback loop is formed by a two-stage SiC operational amplifier. Both internal and external passive components are used in the frequency compensation network. An external 7.5 V supply is connected to the operational amplifier and acts as the reference voltage. At 400 °C, experimental results show a line regulation of better than 1.5 mV/V under a 100-mA load. The load regulation with a 30-V input and at 400 °C is shown to be 0.42 mV/mA. Sustained operation of the linear regulator is demonstrated over 30 h at 300 °C.
Solid state bonding of spheroidal graphite cast irons. (Report 2). Effect of post bond heat treatment on bonding strength of spheroidal graphite cast irons. (1988)

The strength of the diffusion bonded joints of ductile cast irons having the strength of 360 (FCD 37) or 490 MPa (FCD 50) and the ductile cast iron to a mild steel had been investigated in the 1st report. In this report, the effects of the post bond heat treatments-annealing for ferritization and normalizing for structure changing of matrix-have been studied. The results obtained are as follows; (1) The tensile fracture of the joints which were annealed after that bonding carried out using the insert metals of Ni or Fe foils occurred in the base metal. However, both joints without a insert metal and with Cu foil fractured at the bonding interface. (2) When the ductile cast irons were directly bonded without a insert metal the joint strength after annealing depended on the volume fraction of graphites which precipitated on the bonding interface by decomposition of Fe3C during annealing, and abruptly deteriorated with increasing the fraction of these graphites. This graphite volume fraction increased in proportion to the pearlite volume fraction around bonding interface before annealing. (3) As to the joints of the ductile cast iron to the mild steel, the joint strength after annealing depended on the bondability between the ductile cast iron and the insert metal. Except the insert metal of Cu foil, the tensile fracture occurred at the mild steel side away from the insert metal. (4) The tensile strength of ductile-ductile joints increased as the volume fraction of pearlite formed in matrix by normalizing for structure changing incrased and was the same as that of the base metal up to 550 MPa. When the strength of the base metal was higher than 550 MPa the joint strength reached the plateau value of 85% of the base metal strength. (5) On the other hand, the strength of both joints without the insert metal and with Cu foil did not exceed 80% of the base metal strength of 430 to 1000 MPa.
Liver-Oriented Acute Metabolic Effects of A Low Dose of L-Carnitine under Fat-Mobilizing Conditions: Pilot Human Clinical Trial (2020)

The acute metabolic effect of low dosages of L-carnitine under fat-mobilizing conditions was investigated. Healthy subjects (Study 1: n=5; Study 2: n=6) were asked to fast overnight. Then, 30 min of aerobic exercise on a cycle ergometer was performed after supplementation, followed by a 3.5-h sedentary recovery phase. The following ingestion patterns were used: Study 1 (i) noningestion, (ii) 750 mg of L-carnitine (LC), and (iii) 750 mg of LC+50 g of carbohydrate (CHO); Study 2 (iv) noningestion, (v) 500 mg of LC, (vi) 30 mg of CoQ<sub>10</sub>, and (vii) 500 mg of LC+30 mg of CoQ<sub>10</sub>. The energy expenditure (EE) and nonprotein respiratory quotient (npRQ) were measured during the pre-exercise, postexercise, and recovery periods. Serum free carnitine, acetylcarnitine, total carnitine (Study 1 and 2), and ketone bodies (Study 2) were measured. The 750 mg LC treatment significantly facilitated fat oxidation during the recovery phases (p<0.05) without elevating EE. The higher fat oxidation associated with LC was completely suppressed by CHO. CoQ<sub>10</sub> affected neither npRQ nor EE. npRQ was significantly correlated with the serum total ketone bodies (R=-0.68, p<0.001) and acetylcarnitine (R=-0.61--0.70, p<0.001). The highest correlation was found between acetylcarnitine and total ketone bodies immediately after exercise (R=0.85, p<0.001). In conclusion, LC enhanced liver fat utilization and ketogenesis in an acute manner without stimulating EE under fat-mobilizing conditions.
Structural motion control using modal energy transference (2002)

The authors describe the preliminary work on a semi-active method for structural motion control in a structural system. By the appropriate control of a system stiffness, the energy in different modes can be steered into other modes. The analytical formulation is presented, and was supported by a simple simulation experiment. The proposed approach introduces minimal energy into the system and will thus never result in modal spillover. >
Translating ENIGMA schizophrenia findings using the regional vulnerability index: Association with cognition, symptoms, and disease trajectory (2020)

Patients with schizophrenia have patterns of brain deficits including reduced cortical thickness, subcortical gray matter volumes, and cerebral white matter integrity. We proposed the regional vulnerability index (RVI) to translate the results of Enhancing Neuro Imaging Genetics Meta-Analysis studies to the individual level. We calculated RVIs for cortical, subcortical, and white matter measurements and a multimodality RVI. We evaluated RVI as a measure sensitive to schizophrenia-specific neuroanatomical deficits and symptoms and studied the timeline of deficit formations in: early (≤5 years since diagnosis, N = 45, age = 28.8 ± 8.5); intermediate (6-20 years, N = 30, age 43.3 ± 8.6); and chronic (21+ years, N = 44, age = 52.5 ± 5.2) patients and healthy controls (N = 76, age = 38.6 ± 12.4). All RVIs were significantly elevated in patients compared to controls, with the multimodal RVI showing the largest effect size, followed by cortical, white matter and subcortical RVIs (d = 1.57, 1.23, 1.09, and 0.61, all p < 10<sup>-6</sup> ). Multimodal RVI was significantly correlated with multiple cognitive variables including measures of visual learning, working memory and the total score of the MATRICS consensus cognitive battery, and with negative symptoms. The multimodality and white matter RVIs were significantly elevated in the intermediate and chronic versus early diagnosis group, consistent with ongoing progression. Cortical RVI was stable in the three disease-duration groups, suggesting neurodevelopmental origins of cortical deficits. In summary, neuroanatomical deficits in schizophrenia affect the entire brain; the heterochronicity of their appearance indicates both the neurodevelopmental and progressive nature of this illness. These deficit patterns may be useful for early diagnosis and as quantitative targets for more effective treatment strategies aiming to alter these neuroanatomical deficit patterns.
The pyrido[1,2-a]azepine Stemona alkaloids (2007)

This paper reviews the isolation, structure elucidation, proposed biosynthesis and biological activities of the small, but increasing, number of pyrido[1,2-a]azepine Stemona alkaloids.
Three-Dimensional Spatial Information Systems: State of the Art Review (2010)

A spatial information system (SIS) is critical to the hosting, querying, and analyzing of spatial data sets. The increasing availability of three-dimensional (3D) data (e.g. from aerial and terrestrial laser scanning) and the desire to use such data in large geo-spatial platforms have been dual drivers in the evolution of integrated SISs. Within this context, recent patents demonstrate efforts to handle large data sets, especially complex point clouds. While the development of feature-rich geo-systems has been well documented, the implementation of support for 3D capabilities is only now being addressed. This paper documents the underlying technologies implemented for the support for 3D features in SISs. Examples include ESRI’s ArcGIS geo-database with its support for two-and-a-half dimensions (2.5D) in its Digital Elevation Model (DEM) and Triangular Irregular Network (TIN), the more recent development of the Terrain feature class, and support for 3D objects and buildings with its multi-patch feature class. Recent patents and research advances aim to extract DEMs and TINs automatically from point cloud data. In this context, various data structuring innovations are presented including both commercial and open source alternatives.
Dual-pump Optical Parametric Oscillation in a 4H-SiC-on-insulator Microring Resonator (2021)

Silicon carbide (SiC) has large refractive index, wide bandgap, and strong material-based second- and third-order nonlinearities. Thus, in recent years, SiC has attracted considerable interests in quantum and nonlinear integrated photonics [1] – [3] with potential applications within broadband nonlinear light sources, including photon-pair sources, supercontinuum generation, and frequency combs. Optical parametric oscillation (OPO) is regarded as a promising way to produce new frequencies and an important tool in generation of coherent light sources, such as frequency combs. In this work, we experimentally demonstrate a Kerr-nonlinearity based dual continuous-wave(CW) pumped OPO in a 4H-SiC-on-insulator (4H-SiCOI) microring resonator.
Carboxylic Acid‐Functionalized Conjugated Polymer Promoting Diminished Electronic Drift and Amplified Proton Sensitivity of Remote Gates Compared to Nonpolar Surfaces in Aqueous Media (2020)

Abstract A systematic analysis is used to understand electrical drift occurring in field‐effect transistor (FET) dissolved‐analyte sensors by investigating its dependence on electrode surface‐solution combinations in a remote‐gate (RG) FET configuration. Water at pH 7 and neat acetonitrile, having different dipoles and polarizabilities, are applied to the RG surface of indium tin oxide, SiO 2 , hexamethyldisilazane‐modified SiO 2 , polystyrene, poly(styrene‐ co ‐acrylic acid), poly(3‐hexylthiophene‐2,5‐diyl) (P3HT), and poly [3‐(3‐carboxypropyl)thiophene‐2,5‐diyl] (PT‐COOH). It is discovered that in some cases a slow reorientation of dipoles at the interface induced by gate electric fields causes severe drift and hysteresis because of induced interface potential changes. Conductive and charged P3HT and PT‐COOH increase electrochemical stability by promoting fast surface equilibrations. It is also demonstrated that pH sensitivity of P3HT (17 mV per pH) is an indication of proton doping. PT‐COOH shows further enhanced pH sensitivity (30 mV per pH). This combination of electrochemical stability and pH response in PT‐COOH are proposed as advantageous for polymer‐based biosensors.
Neutrophil Activation in Experimental Venous Hypertension (1994)

Objective: To investigate the white cell trapping hypothesis of venous ulceration by measuring plasma lactoferrin as a marker of neutrophil degranulation in normal volunteers in two experimental models of venous hypertension. Design: A prospective study of volunteers with no history or clinical evidence of venous disease. Setting: The Middlesex Hospital Vascular Laboratory, Mortimer Street, London WIN 8AA, UK. Patients: Volunteers within the Middlesex Hospital Vascular Laboratory with no history or clinical findings of venous or arterial disease, no other systemic disease, on no medication known to alter white cell activity, and with no recent infection. Interventions: Venous blood was taken from cannulae in both feet and the right arm for a neutrophil count and Plasma lactoferrin, measured using an ELISA, during application of a tourniquet to 80 mmHG for 30 min to the right leg while supine, 5 min after release of tourniquet, and then during a 30 min period of standing. Results: During application of a tourniquet to the right leg there was a significant rise in plasma lactoferrin and in lactoferrin corrected for the neutrophil count ( p &lt; 0.05, Wilcoxon). In the unoccluded leg, although Plasma lactoferrin rose, this was not significant when corrected for the rise in neutrophil count. After standing for 30 min, the lactoferrin and neutrophil count increased in all three limbs; corrected lactoferrin showed a significant increase in the legs ( p &lt; 0.02), though not in the arm. Conclusion: Increased neutrolphil degranulation occurs during periods of short-term venous hypertension in normal volunteers, in keeping with the white cell trapping hypothesis.
Crystal structure of 4-(2-ammonioethyl)morpholin-4-ium dichloride monohydrate, C6H18Cl2N2O2 (2017)

Abstract C 6 H 18 Cl 2 N 2 O 2 , triclinic, P 1̅ (no. 2), a = 7.9597(11) Å, b = 9.1223(13) Å, c = 9.2893(12) Å, α = 118.575(3)°, β = 106.507(4)°, γ = 97.120(4)°, V = 540.21(13) Å 3 , Z = 2, R gt ( F ) = 0.0470, wR ref ( F 2 ) = 0.1156, T = 293 K.
ChemInform Abstract: Synthesis of a Chiral Hexane‐1,6‐dinitrile from D‐Glucose. (1989)

Abstract The tribenzoyloxycyclohexanone (I), prepared from D‐glucose, is subjected to catalytic hydrogenation and then converted to the oxime (IV) which undergoes regiospecific reaction with the azide (V), yielding the 2‐azido derivative (VI).