gebhart/patrepeval huggingface dataset:
Synthesis and Characterization of (Octaethylporphyrinato)ruthenium(II) and -ruthenium(III) Complexes with Thioether, Sulfoxide, and Benzoate Axial Ligands (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and Characterization of (Octaethylporphyrinato)ruthenium(II) and -ruthenium(III) Complexes with Thioether, Sulfoxide, and Benzoate Axial LigandsAndrew Pacheco, Brian R. James, and Steven J. RettigCite this: Inorg. Chem. 1995, 34, 13, 3477–3484Publication Date (Print):June 1, 1995Publication History Published online1 May 2002Published inissue 1 June 1995https://pubs.acs.org/doi/10.1021/ic00117a016https://doi.org/10.1021/ic00117a016research-articleACS PublicationsRequest reuse permissionsArticle Views131Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Application of Vinyl Tris(trimethylsilyl)germanes in Pd-Catalyzed Couplings (2005)

The oxidative treatment of vinyltris(trimethylsilyl)germanes with hydrogen peroxide (NaOH/H(2)O/THF) or tert-butyl peroxide (KH/THF) generates reactive germanol or germanoxane species that undergo Pd-catalyzed cross-couplings with aryl and alkenyl halides and aryl triflates in the presence of Pd(PPh(3))(4). Vinylgermanes having either a conjugated or isolated double bond serve as versatile transmetalation reagents. The E-germanes undergo coupling with retention of stereochemistry under aqueous and anhydrous conditions, while coupling of Z-germanes occurs with less stereoselectivity to produce a mixture of E/Z products.
Redefining routing and channel access in ad hoc networks (2011)

No abstract available.
L‐typeCa2+channel current characteristics are preserved in rat tail artery myocytes after one‐day storage (2014)

Findings show that smooth muscle contractile activity and the biophysical and pharmacological features of L-type Ca(2+) channels are similar in VSMC24h and VSMC0h. The fact that reproducible results were obtained in vascular myocytes up to 24 h after dissociation may facilitate vascular smooth muscle cell investigation by increasing throughput and reducing the number of animals required.
ChemInform Abstract: COB(I)ALAMIN AS A CATALYST. PART 1. REDUCTION OF SATURATED NITRILES IN AQUEOUS SOLUTION (1979)

Abstract Carbonitrile werden in Gegenwart katalytischer Mengen der Titelverbindung (I) in Eisessig unter Argon bei 20°C und Tageslicht zu Carbaldehyden reduziert.
Synthesis and Biological Activities of a 3'-Azido Analogue of Doxorubicin Against Drug-Resistant Cancer Cells (2012)

Doxorubicin (DOX), an anthracycline antibiotic, is one of the most active anticancer chemotherapeutic agents. The clinical use of DOX, however, is limited by the dose-dependant P-glycoprotein (P-gp)-mediated resistance. Herein, a 3'-azido analogue of DOX (ADOX) was prepared from daunorubicin (DNR). ADOX exhibited potent antitumor activities in drug-sensitive (MCF-7 and K562) and drug-resistant cell lines (MCF-7/DNR, K562/DOX), respectively. The drug resistance index (DRI) values of ADOX were much lower than that of DOX. The cytotoxicity experiments of ADOX or DOX against K562/DOX, with or without P-gp inhibitor, indicated that ADOX circumvents resistance by abolishing the P-gp recognition. This conclusion was further supported by drug influx/efflux flow cytometry experiments, as well as by molecular docking of ADOX to P-gp. In vivo animal tests, ADOX exhibited higher activity and less toxicity than DOX. The current data warranted ADOX for additional pre-clinical evaluations for new drug development.
P631 Long-term safety of vedolizumab versus other biologic agents in ulcerative colitis (UC) and Crohn’s Disease (CD): Results from a large multinational prospective observational study (2023)

Abstract Background Vedolizumab (VDZ) is a gut-selective humanised monoclonal anti-α4β7 integrin antibody for treatment of UC and CD. This post-authorization safety study (PASS) compared long-term safety in patients (pts) treated with VDZ or other biologics for UC or CD. Methods This was a prospective, observational, multicentre, cohort study in pts with UC or CD starting treatment with VDZ or other biologics (NCT02674308, EUPAS6469). Pts were biologic naïve (VDZ=35%, Other biologic=65%) or had prior exposure to biologics other than VDZ and were followed for up to 7 yrs. Pts were treated under usual standard of care as directed by their physician with no discontinuation from the study due to physician-directed treatment changes. The primary safety outcome was serious infections and was compared between cohorts using a Cox proportional hazards model adjusted by propensity score (with other biologics as reference). Secondary safety outcomes were adverse events (AE) of special interest (AESI) as listed in Tables 2 and 3. Results In total, 5208 patients were enrolled across 21 countries between Mar 2015 and Jul 2019. The full analysis set comprised 5008 pts (VDZ=2502; other biologic=2506) and mean (SD) study duration was 37.4 (14.1) months. Consistent with the observational nature of the study and the current standard of care, the baseline characteristics in the two cohorts were imbalanced (Table 1). The overall treatment-emergent Adverse Event (AE) rate was 61.3% (VDZ) and 59.5% (other biologic), with serious AEs in 27.5% (VDZ) and 25.7% (other biologic), respectively. In UC pts, the incidence rate (IR) of serious infections were: 0.014 (95% CI: 0.010, 0.019) [VDZ] and 0.015 (0.010, 0.023) [other biologic], with a hazard ratio (HR) of 1.018 (0.931, 1.114), p=0.70 (Table 2). In CD pts, corresponding findings were 0.012 (95% CI: 0.008, 0.017) [VDZ] and 0.006 (95% CI: 0.004, 0.009) [other biologic] with HR of 1.035 (0.959, 1.117), p=0.38 (Table 3). The incidence of primary and secondary safety outcomes is reported in Table 2 for UC and Table 3 for CD. There were no safety issues relating to pregnancy and no cases of PML observed. There were 19 deaths in the VDZ cohort (1 case of pneumonia deemed as treatment-related); and 13 deaths in the other biologic cohort, 2 cases deemed treatment-related (one case septic shock and pneumonia; one case non-small cell lung cancer). Clinical outcomes and quality of life (QoL) measures were comparable between cohorts. Conclusion In this long-term, prospective, real-world observational study of a large multinational population under routine standard of care there was no new safety signal identified in relation to VDZ. Results are consistent with the known safety profile of VDZ.
Polyamides and polyesters containing 2,4:3,5‐di‐O‐methylene‐L‐idaroyl residues (1990)

Abstract Electrochemical oxidation of 2,4:3,5‐di‐ O ‐methylene‐D‐gluconic acid in strong alkaline medium afforded a mixture of 2,4:3,5‐di‐ O ‐methylene‐D‐glucaric acid 4 and 2,4:3,5‐di‐ O ‐methylene‐L‐idaric acid 1 in a 1/8 ratio with a current efficiency of 53%. Force‐field calculations using Allinger's molecular mechanics program MM2p85 on 1 and 4 indicate that these cis ‐fused tetrahydro‐[1,3]dioxino[5,4‐ d ]‐1,3‐dioxin ring systems possess an O‐inside conformation with a steric energy of 110.3 and 123.5 kJ·mol −1 , respectively. Their conformation was confirmed by 400‐MHz 1 H‐ and 100‐MHz 13 C NMR measurements. A series of polycondensates were prepared by homogeneous solution polymerisation of 1 with an aromatic diol or aromatic diamine, which were analyzed by DSC and TGA.
A Model of Integrating Virtual and Real Objects Based on Contour Algorithm and Gabor Filter (2012)

The key of augmented reality for e-commerce is the integrated presentation of virtual objects and real-world objects. In the current two mainstream models of integration, GPS in the GPS-based model couldn’t obtain data in real ecommerce scene, and the camera-based 3D registration model requires dedicated camera equipment, which couldn’t meet the requirements of the application conditions. It was proposed in this model that the concerned object was split from the image, which was captured with the mobile phone camera, using Contour algorithm, and then, the Gabor filtering algorithm was used to obtain the features of real objects and these features were used to generate virtual objects. At last, the virtual objects and real objects were integrated and presented to users.
CD147: a small molecule transporter ancillary protein at the crossroad of multiple hallmarks of cancer and metabolic reprogramming (2016)

Increased expression of CD147 in pancreatic cancer has been proposed to play a critical role in cancer progression via CD147 chaperone function for lactate monocarboxylate transporters (MCTs). Here, we show for the first time that CD147 interacts with membrane transporters beyond MCTs and exhibits a protective role for several of its interacting partners. CD147 prevents its interacting partner's proteasome-dependent degradation and incorrect plasma membrane localization through the CD147 transmembrane (TM) region. The interactions with transmembrane small molecule and ion transporters identified here indicate a central role of CD147 in pancreatic cancer metabolic reprogramming, particularly with respect to amino acid anabolism and calcium signaling. Importantly, CD147 genetic ablation prevents pancreatic cancer cell proliferation and tumor growth in vitro and in vivo in conjunction with metabolic rewiring towards amino acid anabolism, thus paving the way for future combined pharmacological treatments.
Forecasting the ocean optical environment in support of Navy mine warfare operations (2012)

A 3D ocean optical forecast system called TODS (Tactical Ocean Data System) has been developed to determine the performance of underwater LIDAR detection/identification systems. TODS fuses optical measurements from gliders, surface satellite optical properties, and 3D ocean forecast circulation models to extend the 2-dimensional surface satellite optics into a 3-dimensional optical volume including subsurface optical layers of beam attenuation coefficient (c) and diver visibility. Optical 3D nowcast and forecasts are combined with electro-optical identification (EOID) models to determine the underwater LIDAR imaging performance field used to identify subsurface mine threats in rapidly changing coastal regions. TODS was validated during a recent mine warfare exercise with Helicopter Mine Countermeasures Squadron (HM-14). Results include the uncertainties in the optical forecast and lidar performance and sensor tow height predictions that are based on visual detection and identification metrics using actual mine target images from the EOID system. TODS is a new capability of coupling the 3D optical environment and EOID system performance and is proving important for the MIW community as both a tactical decision aid and for use in operational planning, improving timeliness and efficiency in clearance operations.
Evaluation of a Novel Visual Field Analyzer Application for Automated Classification of Glaucoma Severity (2017)

The GSA allows an automated, fast, reproducible, and objective classification system for multiple 24-2 VFs of Humphrey perimetry. This study is a proof-of-concept that could translate into a useful tool to analyze and stage VFs more objectively and thus help detecting progression of different types of VFs defects.
Infection of Pro- and Anti-Inflammatory Macrophages by Wild Type and Vaccine Strains of Measles Virus: NLRP3 Inflammasome Activation Independent of Virus Production (2023)

In humans and non-human primates, wild type (WT) measles virus (MeV) replicates extensively in lymphoid tissue and induces an innate response characteristic of NF-κB and inflammasome activation without type I interferon. In contrast, the live attenuated MeV vaccine (LAMV) replicates poorly in lymphoid tissue with little detectable in vivo cytokine production. To characterize the innate responses of macrophages to WT MeV and LAMV infection, we analyzed primary human monocyte-derived macrophages and phorbol myristic acid-matured monocytic THP-1 cells (M0) polarized to inflammatory (M1) and anti-inflammatory (M2) phenotypes 24 h after MeV infection. LAMV infected macrophages more efficiently than WT MeV but produced less virus than WT MeV-infected macrophages. Both strains induced production of NF-κB-responsive cytokines IL-6 and TNFα and inflammasome products IL-1β and IL-18 without evidence of pyroptosis. Analysis of THP-1 cells deficient in inflammasome sensors NOD-like receptor pyrin (NLRP)3, IFN-γ-inducible protein 16 (IFI16) or absent in melanoma (AIM)2; adaptor apoptosis-associated speck-like protein containing a CARD (ASC) or effector caspase 1 showed that IL-18 production was dependent on NLRP3, ASC, and caspase 1. However, M1 cells produced IL-1β in the absence of ASC or caspase 1 indicating alternate pathways for MeV-induced pro-IL-1β processing. Therefore, the innate response to in vitro infection of macrophages with both LAMV and WT MeV includes production of IL-6 and TNFα and activation of the NLRP3 inflammasome to release IL-1β and IL-18. LAMV attenuation impairs production of infectious virus but does not reduce ability to infect macrophages or innate responses to infection.
Asymmetric Autocatalysis as a Relay for Remote Amplification of Chirality of Target Molecules Used as Triggers (2016)

Nearly racemic target molecules are enantiomerically enriched through an asymmetric autocatalytic relay for a remote amplification of chirality. Target alkynols with very low initial ee act as chiral triggers for asymmetric amplification of the Soai autocatalyst, which in turn enables the formation of the same alkynols with greater enantiomeric purity. Additionally, the stereochemical correlation between the trigger/target and autocatalyst molecules is discussed.
Cushingʼs Syndrome (1995)

Department of Internal Medicine (Endocrinology), Emory University School of Medicine, 1365 Clifton Road, N.E., Atlanta, GA 30322
Toward Recyclable Thermosets (2014)

Advances in synthesis are leading to thermoset plastics that can be converted to the starting monomers. [Also see Report by García et al. ]
Stable All Solid State Z-Scheme Based TiO2/M/CdxZn1-Xs Photo-Catalysts for Efficient Hydrogen Generation (2018)

Water splitting to hydrogen and oxygen molecules suing semiconductors as photocatalysts to store solar energy, is one of the “Holy Grails” in solar energy conversion 1 . The performance of a photocatalyst is largely limited by four requirements: 1) long term stability with respect to photo corrosion, 2) a narrow band gap materials to absorb a large fraction of solar light, 3) suitable band edges that match the redox potential of water, and 4) slow charge carrier recombination systems. In particular, with respect to point 4, many artificial Z-scheme based photocatalytic systems have been widely investigated 2 . Recently, Rao et al., 3 reported an all-solid state Z-scheme anisotropic ZnO/Pt/Cd 0.8 Zn 0.2 S heterojunction system which exhibited a high photocatalytic activity owing to an efficient electron-hole transfer between the ZnO conduction band and the CdS valence band through Pt nanoparticles (using benzyl alcohol and acetic acid as sacrificial reagents). However, this system is not stable over the long term mainly because ZnO is stable in a very narrow pH range (6-8) 4 , whereas the ideal pH for hydrogen production, either by sacrificial or direct water splitting, is often outside this range. As a consequence, the original Z-scheme structure is gradually destroyed following the dissolution of the ZnO which subsequently causes the decomposition of Cd 0.8 Zn 0.2 S. In this work, we have developed a novel TiO 2 /Ag-Pd/Cd(Zn)S based Z-scheme photocatalytic system. This system was found to be stable in the presence of aqueous solution containing benzyl alcohol/acetic acid (the role of both has been investigated). Catalysts were prepared and characterized by XRD, XPS, TEM and UV-Vis and the catalytic tests were conducted over the complete series of the Z-Scheme system and its individual components such as Ag-Pd/TiO 2 and Cd 0.8 Zn 0.2 S. The hydrogen generation rate of the best system and that of its components were 3.3 mmol/h.g catal. (TiO 2 /Ag-Pd/Cd 0.8 Zn 0.2 S), 1.1 mmol/h.g catal. (Ag-Pd/TiO 2 ) and 0.5 mmol/h.g catal. (Cd 0.8 Zn 0.2 S) respectively under identical conditions as described below. Figure 1
Treatment of chronic moderate-to-severe non-malignant pain with polymer-coated extended-release morphine sulfate capsules (2006)

P-ERMS was efficacious and well tolerated in patients with chronic, moderate-to-severe, non-malignant pain when used once or twice daily.
MRI Reconstruction with Side Information using Diffusion Models (2023)

Magnetic resonance imaging (MRI) exam protocols consist of multiple contrast-weighted images of the same anatomy to emphasize different tissue properties. Due to the long acquisition times required to collect fully sampled k-space measurements, it is common to only collect a fraction of k-space for each scan and subsequently solve independent inverse problems for each image contrast. Recently, there has been a push to further accelerate MRI exams using data-driven priors, and generative models in particular, to regularize the ill-posed inverse problem of image reconstruction. These methods have shown promising improvements over classical methods. However, many of the approaches neglect the additional information present in a clinical MRI exam like the multi-contrast nature of the data and treat each scan as an independent reconstruction. In this work we show that by learning a joint Bayesian prior over multi-contrast data with a score-based generative model we are able to leverage the underlying structure between random variables related to a given imaging problem. This leads to an improvement in image reconstruction fidelity over generative models that rely only on a marginal prior over the image contrast of interest.
Design and Performance of a Horizontal Well Waterflood Project in New Hope Shallow Unit, Franklin County, Texas (1992)

Abstract In 1991, a pair of horizontal wells were drilled in the Pittsburg "C" sandstone reservoir of the New Hope Shallow Unit (NHSU) in East Texas. The first well was a 1500-ft horizontal oil well and the second was a 1500-ft water injection well. The NHSU Pittsburg formation is a relatively tight sandstone reservoir undergoing a waterflood project expansion. It has a 45-year production history and is located at a depth of about 8000 feet. A single well model was used to predict horizontal well production potential and compare a horizontal development to a conventional vertical well development. After the initial evaluation appeared favorable, a fieldwide simulation study, including a 45-year history match and a horizontal well production forecast with and without a horizontal injection well, was made to further assess the project. Different scenarios were examined to determine the optimum development program. The wells were drilled in the last quarter of 1991. Actual production results appear to be tracking the forecast rates. This paper summarizes the reservoir engineering studies performed as well as the planning, drilling and completion of these wells. Production histories as well as problems and their solutions to date are also documented. The application of horizontal wells in sandstone reservoirs demonstrates that new life can be brought to mature oil fields.
Asymmetric Epoxidation of Simple Olefins by Chiral Bitetralin-Linked “Twin-Coronet” Porphyrin Catalysts (1993)

Abstract Catalytic and asymmetric epoxidation of styrenes and related aryl substituted olefins with the iron complexes of chiral bitetralin (Bitet)–linked “twin–coronet” porphyrins was performed with iodosylbenzene as an oxidant. Among two topological isomers of the catalyst, the eclipsed one (5b) showed higher enantioselectivity than the staggered (6b). With 5b, the resulting epoxides, except for the olefins bearing an electron–donating substituent, were obtained in good to excellent enantioselectivity (54—96% ee), especially for the styrenes with electron–withdrawing substituent(s). Being different from other porphyrin–based chiral catalysts, the catalyst 5b is robust enough under the applied oxidation conditions to exhibit chiral epoxidation with the same ee and the same rate as those of the initial period of the reaction even after about 500 turnovers. The Bitet catalyst is superior in the epoxide enantioselectivity than the corresponding chiral binaphthalene (Binap)–linked catalyst (3b). In the reactions with the catalysts 3b and 5b, good correlation in epoxide ees was observed. Increase of the epoxide ee in the reaction with the Bitet catalyst was elucidated by the shape and size of the reaction cavities of the Bitet were tighter than those of the latter. The observed ees of the substituted styrene oxides showed good correlation with Σσ+ values of their substituent(s). In the reaction with the electron–deficient olefins, π–π* interaction between the HOMO of the electron–rich Bitet auxiliary ring and the LUMO of the electron–deficient aryl ring of the substrate are pointed out as the key for the realization of high ees. Some nitrostyrenes, however, gave rather lower ees in spite of rather higher degree of their electron deficiency. This deviation was elucidated by the mismatching of their frontier orbitals.
Revised structure of helvoic acid (1970)

S. Iwasaki, M. I. Sair, H. Igarashi and S. Okuda, J. Chem. Soc. D, 1970, 1119 DOI: 10.1039/C29700001119
A laparoscopic telesurgical workstation (1999)

In this paper, various aspects of robotic telesurgery are studied. After a general introduction to laparoscopic surgery and medical applications of robotics, the UC Berkeley/Endorobotics Inc./UC San Francisco Telesurgical Workstation, a master-slave telerobotic system for laparoscopic surgery, is introduced, followed by its kinematic analysis, control, and experimental results. Some conceptual and future issues on telesurgery are discussed, including teleoperation and hybrid control, focusing on the special requirements of telesurgery.
Early diagnosis of acute myocardial infarction using high-sensitivity troponin I (2017)

www.clinicaltrials.gov (NCT02355457).