gebhart/patrepeval huggingface dataset:
Magnetic and magnetoelastic properties of Cr-substituted cobalt ferrite (2007)

We have investigated the magnetic and magnetoelastic properties of a series of Cr-substituted cobalt ferrite CoCrxFe2−xO4 (x=0.0–0.79) samples. Substitution of Cr for some of the Fe in cobalt ferrite reduced the Curie temperature, and the effect is more pronounced than that observed in Mn-substituted cobalt ferrite samples. Cr substitution also caused the maximum magnetostriction to decrease at a greater rate than substitution of the same amount of Mn. The maximum of the strain derivative, dλ∕dH, was reached for x=0.38. The behavior of the Curie temperature of Cr-substituted and Mn-substituted cobalt ferrites has been analyzed using the Néel molecular field model and compared with recent Mössbauer spectroscopy results.
A QUANTITATIVE EVALUATION OF OTT AND MEDER'S PREDICTION ERROR FILTER* (1977)

A bstract Ott and Meder's prediction error filter can be rederived so that it correctly handles input noise vectors which are of smaller dimension than the state vector. The poor performance obtained by Ott and Meder for their example can be explained by means of the error covariance matrix for the prediction error filter.
A terbenzimidazole that preferentially binds and conformationally alters structurally distinct DNA duplex domains: A potential mechanism for topoisomerase I poisoning (1997)

The terbenzimidazoles are a class of synthetic ligands that poison the human topoisomerase I (TOP1) enzyme and promote cancer cell death. It has been proposed that drugs of this class act as TOP1 poisons by binding to the minor groove of the DNA substrate of TOP1 and altering its structure in a manner that results in enzyme-mediated DNA cleavage. To test this hypothesis, we characterize and compare the binding properties of a 5-phenylterbenzimidazole derivative (5PTB) to the d(GA4T4C)2 and d(GT4A4C)2 duplexes. The d(GA4T4C)2 duplex contains an uninterrupted 8-bp A.T domain, which, on the basis of x-ray crystallographic data, should induce a highly hydrated "A-tract" conformation. This duplex also exhibits anomalously slow migration in a polyacrylamide gel, a feature characteristic of a noncanonical global conformational state frequently described as "bent." By contrast, the d(GT4A4C)2 duplex contains two 4-bp A.T tracts separated by a TpA dinucleotide step, which should induce a less hydrated "B-like" conformation. This duplex also migrates normally in a polyacrylamide gel, a feature further characteristic of a global, canonical B-form duplex. Our data reveal that, at 20 degrees C, 5PTB exhibits an approximately 2. 3 kcal/mol greater affinity for the d(GA4T4C)2 duplex than for the d(GT4A4C)2 duplex. Significantly, we find this sequence/conformational binding specificity of 5PTB to be entropic in origin, an observation consistent with a greater degree of drug binding-induced dehydration of the more solvated d(GA4T4C)2 duplex. By contrast with the differential duplex affinity exhibited by 5PTB, netropsin and 4',6-diamidino-2-phenylindole (DAPI), two AT-specific minor groove binding ligands that are inactive as human TOP1 poisons, bind to both duplexes with similar affinities. The electrophoretic behaviors of the ligand-free and ligand-bound duplexes are consistent with 5PTB-induced bending and/or unwinding of both duplexes, which, for the d(GA4T4C)2 duplex, is synergistic with the endogenous sequence-directed electrophoretic properties of the ligand-free duplex state. By contrast, the binding to either duplex of netropsin or DAPI induces little or no change in the electrophoretic mobilities of the duplexes. Our results demonstrate that the TOP1 poison 5PTB binds differentially to and alters the structures of the two duplexes, in contrast to netropsin and DAPI, which bind with similar affinities to the two duplexes and do not significantly alter their structures. These results are consistent with a mechanism for TOP1 poisoning in which drugs such as 5PTB differentially target conformationally distinct DNA sites and induce structural changes that promote enzyme-mediated DNA cleavage.
Supplementary Figure from Preclinical Characterization of AZD5305, A Next-Generation, Highly Selective PARP1 Inhibitor and Trapper (2023)

Supplementary Figure from Preclinical Characterization of AZD5305, A Next-Generation, Highly Selective PARP1 Inhibitor and Trapper
Biomaterials Science Emerging Investigators themed issue (2014)

P. Messersmith and N. Nakatsuji, Biomater. Sci., 2014, 2, 602 DOI: 10.1039/C4BM90005G
Macrophage Imaging Within Human Cerebral Aneurysms Wall Using Ferumoxytol-Enhanced MRI: A Pilot Study (2012)

Imaging with T2*-GE-MRI at 72 hours postinfusion of 5 mg/kg of ferumoxytol establishes a valid and useful approximation of optimal dose and timing parameters for macrophages imaging within aneurysm wall. Further studies are needed to correlate these imaging findings with risk of intracranial aneurysm rupture.
[Maternal serum concentration of angiogenic factors: PIGF, VEGF and VEGFR-1 and placental volume in pregnancies complicated by intrauterine growth restriction]. (2007)

Presented and documented dependencies may indicate the involvement of angiogenic factors in a pathomechanism of intrauterine growth restriction process. It seems that the measurement of placental volume may be useful in IUGR diagnosis. However, it should be a complementary examination only, due to technical limitations.
Liver and Skin Histopathology in Adults With Acid Sphingomyelinase Deficiency (Niemann-Pick Disease Type B) (2012)

Acid sphingomyelinase deficiency (ASMD) is a lysosomal storage disorder characterized by the pathologic accumulation of sphingomyelin (SM) in multiple cell types, and occurs most prominently within the liver, spleen, and lungs, leading to significant clinical disease. Seventeen ASMD patients underwent a liver biopsy during baseline screening for a phase 1 trial of recombinant human acid sphingomyelinase (rhASM) in adults with Niemann-Pick disease type B. Eleven of the 17 were enrolled in the trial and each received a single dose of rhASM and underwent a repeat liver biopsy on day 14. Biopsies were evaluated for fibrosis, SM accumulation, and macrophage infiltration by light and electron microscopy. When present, fibrosis was periportal and pericellular, predominantly surrounding affected Kupffer cells. Two baseline biopsies exhibited frank cirrhosis. SM was localized to isolated Kupffer cells in mildly affected biopsies and was present in both Kupffer cells and hepatocytes in more severely affected cases. Morphometric quantification of SM storage in liver biopsies ranged from 4% to 44% of the microscopic field. Skin biopsies were also performed at baseline and day 14 to compare the SM distribution in a peripheral tissue with that of liver. SM storage was present at lower levels in multiple cell types of the skin, including dermal fibroblasts, macrophages, vascular endothelial cells, vascular smooth muscle cells, and Schwann cells. This phase 1 trial of rhASM in adults with ASMD provided a unique opportunity for a prospective assessment of hepatic and skin pathology in this rare disease and their potential usage as pharmacodynamic biomarkers.
Open tubular capillary column of 50 μm internal diameter with a very high separation efficiency for the separation of peptides in CEC and LC (2017)

A specially designed long open tubular capillary column (50 μm internal diameter and 112 cm effective length) was prepared by fabrication of a thin three-component co-polymer layer on the inner surface of silica capillary. A pretreated silica capillary was reacted with 4-(chloromethyl)phenyl isocyanate in the presence of dibutyltin dichloride as catalyst followed by sodium diethyl dithiocarbamate. Then a thin polymer layer was made on the inner surface of capillary by reversible addition-fragmentation transfer polymerization of styrene, N-phenylacrylamide, and methacrylic acid. A carefully adjusted formulation of reaction mixture and elaborated procedures were adopted to secure formation of the co-polymer layer of enhanced separation performance. The co-polymer immobilized open tubular capillary column was used for the separation of a synthetic mixture of five peptides and excellent separation efficiency (over 1.7 million per column) was obtained in the capillary electrochromatography mode. Such excellent separation efficiencies of ca. 1 m column have not been obtained in the isocratic elution mode so far. The column was also used for separation of the peptides in the liquid chromatography mode to show very good separation efficiency (average 286 700 per column).
Control Over the Innovative Pellet Production Process at TKOM No. 3 at PAO ‘Mikhailovskiy GOK’ Employing the State-of-the-Art Automated Process Control System (2017)

The paper article describes the operating experience of a plant employing state-of-the-art production technology with an MOK-1-592 (TKOM no. 3) indurating machine started up in 2015 at PAO Mikhailovsky GOK. The technical and process solutions implemented in the design of a greenfield production complex is discussed, including a state-of-the-art automated process control system ensuring seamless operation of the equipment in the automated mode and improvement of the product quality. The innovative approach to the performance of the traveling-grate indurating machine and the equipment, which is a part of the heatflow diagram (thermal circuit) of the machine, is based on numerical simulation research of heat and weight transfer in an iron-ore pellet bed. Successful execution of the TKOM no. 3 project is a result of the researchbased and scientifically proven selection of control methods for the pellet production process, the use the state-of-the-industry algorithms for control over the operation modes of the entire production line.
Pros and Cons of Saline Aquifers Against Depleted Hydrocarbon Reservoirs for Hydrogen Energy Storage (2022)

Abstract Hydrogen (H2) is an attractive energy carrier and its true potential is in decarbonizing industries such as providing heat for buildings and being a reliable fuel for trains, buses, and heavy trucks. Industry is already making tremendous progress in cutting costs and improving efficiency of hydrogen infrastructure. Currently heating is primarily provided by using natural gas and transportation by gasoline with a large carbon footprint. Hydrogen has a similarly high energy density but there are technical challenges preventing its large-scale use as an energy carrier. Among these include the difficulty of developing large storage capacities. Underground geologic storage of hydrogen could offer substantial storage capacity at low cost as well as buffer capacity to meet changing seasonal demands or possible disruptions in supply. There are several options for large-scale hydrogen underground storage: lined caverns, salt domes, saline aquifers, and depleted oil/gas reservoirs where large quantities of gaseous hydrogen can be safely and cost-effectively stored and withdrawn as needed. Underground geologic storage must have adequate capacity, ability to inject/extract high volumes with a reliable caprock. A thorough study is essential for a large number of site surveys to locate and fully characterize the subsurface geological storage sites both onshore and offshore. A non-isothermal compositional gas reservoir simulator and its suitability for hydrogen storage and withdrawal from saline aquifers and depleted oil/gas reservoirs was evaluated. The phase behavior, fluid properties, and petrophysical models were all calibrated against published laboratory data of density, viscosity, relative permeability, and capillary pressure for a given site. History-matched dynamic models of two CO2 injection field projects in saline aquifers and one natural gas storage in depleted oil reservoir were considered as hypothetical hydrogen seasonal storage sites. The results revealed the need to contain the stored working gas volume because of high mobility of gaseous H2 with an integrated approach of site selection and its geological features, well locations, and the need for pump wells to maximize the capacity and deliverability.
Body weight status misperception and its association with weight control behaviours, depressive mood and psychological distress in nulliparous normal-weight young women (2015)

Body weight status misperception may be important for understanding weight control-related behaviours and psychiatric illness among nulliparous normal-weight young women.
Variational irreversible thermodynamics of heat and mass transfer in porous solids: new concepts and methods (1978)

A recently developed variational principle of virtual dissipation along with a new approach to the thermodynamics of open systems is applied to coupled mass and heat transfer in a porous solid containing a fluid. General differential field equations are derived directly from the variational principle. A general energy flux theorem is formulated. Vapor-liquid phase transition and capillary condensation are discussed. Field equations for nonequilibrium adsorption are also obtained. Lagrangian equations with generalized coordinates are derived directly from the variational principle without use of the field equations. They provide the foundation of finite-element methods as well as of many other techniques particularly suitable in geothermal systems analysis.
A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease (2010)

Cerebral cavernous malformations (CCMs) are vascular lesions of the central nervous system appearing as multicavernous, blood-filled capillaries, leading to headache, seizure and hemorrhagic stroke. CCM occurs either sporadically or as an autosomal dominant disorder caused by germline mutation of one of the three genes: CCM1/KRIT1, CCM2/MGC4607 and CCM3/PDCD10. Surgically resected human CCM lesions have provided molecular and immunohistochemical evidence for a two-hit (germline plus somatic) mutation mechanism. In contrast to the equivalent human genotype, mice heterozygous for a Ccm1- or Ccm2-null allele do not develop CCM lesions. Based on the two-hit hypothesis, we attempted to improve the penetrance of the model by crossing Ccm1 and Ccm2 heterozygotes into a mismatch repair-deficient Msh2(-/-) background. Ccm1(+/-)Msh2(-/-) mice exhibit CCM lesions with high penetrance as shown by magnetic resonance imaging and histology. Significantly, the CCM lesions range in size from early-stage, isolated caverns to large, multicavernous lesions. A subset of endothelial cells within the CCM lesions revealed somatic loss of CCM protein staining, supporting the two-hit mutation mechanism. The late-stage CCM lesions displayed many of the characteristics of human CCM lesions, including hemosiderin deposits, immune cell infiltration, increased endothelial cell proliferation and increased Rho-kinase activity. Some of these characteristics were also seen, but to a lesser extent, in early-stage lesions. Tight junctions were maintained between CCM lesion endothelial cells, but gaps were evident between endothelial cells and basement membrane was defective. In contrast, the Ccm2(+/-)Msh2(-/-) mice lacked cerebrovascular lesions. The CCM1 mouse model provides an in vivo tool to investigate CCM pathogenesis and new therapies.
The Simple Synthesis of Ferrocene Ligands from a Practitioner's Perspective (Eur. J. Inorg. Chem. 28/2012) (2012)

The cover art is in monochrome in a naive style designed to be eye-catching and to represent the simplicity of the synthetic work described in the Microreview by I. R. Butler on p. 4387ff. The apparatus shown is representative of that used in a typical lithiation experiment and indicates the “hands on” nature of the work – it is intended to express the “magical” feeling one gets every time a new compound is obtained. The globe is used to show that the synthetic methods developed are intended to be implemented by researchers worldwide, because the development of new synthetic methodology has been the driving force for much of the research work. In addition, it is in recognition that ferrocene chemistry is global and that every work published benefits from the accumulated knowledge of others in the field. Finally, the molecules pictured are representative of the broad range of ferrocene compounds that are accessible by using fairly simple synthetic methodology. Hopefully it conveys the idea that lab work is not only hard work but it is also great fun! Further work by the artwork creator, Ross Butler, can be viewed online (http://www.rwbutler.comhttp://www.rwbutler.com).
Ship strike acoustics: It is all just shadows and mirrors (2001)

Whales are vulnerable to collisions when near the surface and in shallow water. Here the physics of near-surface sound propagation may play a crucial role in their survival. Ships sufficient in size to mortally injury whales generate acoustic spectra dominated by very low frequencies. Since the ocean’s pressure-release surface severely attenuates frequencies that are generated at distances less than a wavelength from the surface, whales may not detect low-frequency sounds generated by approaching ships. The Lloyd Mirror Effect predicts sound pressure levels at the surface approximate zero and empirical acoustic measurements support the prediction, while quantifying another important phenomenon associated with large ships, Acoustical Shadowing. The confluence of these acoustic propagation effects pose significant ecological consequences for marine mammals at the surface. While aerial and shipboard monitoring networks help navigate ships away from whales sighted on the surface, these programs are not reliable during conditions of poor visibility and darkness. Further understanding the acoustics of whale/ship collisions could augment protection efforts and result in more consistent and effective management strategies. To mitigate collision risks at times when surveillance programs are ineffective, ships could be projecting directional acoustic signals specifically designed to defeat the Lloyd Mirror Effect and Acoustical Shadowing.
M₃muscarinic receptors mediate acetylcholine-induced pulmonary vasodilation in pulmonary hypertension. (2010)

Information about the muscarinic receptor subtype(s) mediating pulmonary circulatory vasodilator responses to acetylcholine (ACh) is limited. The aim of this study was to pharmacologically characterize the muscarinic receptors associated with ACh-induced pulmonary vasodilation in a pulmonary hypertension model. Vasodilation of rabbit isolated buffer-perfused lungs in which pulmonary hypertension was induced with the thromboxane A₂ analogue U-46619 was evoked by ACh at a just maximally effective concentration (2 x 10⁻⁷ M). The effects of cumulative concentrations of three specific muscarinic receptor subtype antagonists [pirenzepine (M₁), methoctramine (M₂), and 4-diphenylacetoxy-N-methylpiperidine methiodide (4-DAMP, M₃] on ACh-induced pulmonary vasodilation were determined. Double vascular occlusion pressure was recorded to locate the muscarinic receptors within the pulmonary vasculature. Based on the 50% inhibitory concentrations (IC₅₀), the rank of order of antagonist potency was 4-DAMP >> pirenzepine > methoctramine. The vascular effects of all three inhibitors were localized to the precapillary segment. These findings suggest that the vasodilator action of ACh on rabbit isolated perfused U-46619 pretreated lungs is mediated by M₃ muscarinic receptors located in the pulmonary arterial bed.
Xavier: An Autonomous Mobile Robot on the Web (2001)

For the past three years, we have been running an experiment in web-based interaction with an autonomous indoor mobile robot. The robot, Xavier, can accept commands to travel to different offices in our building, broadcasting camera images as it travels. The experiment, which was originally designed to test a new navigation algorithm, has proven very successful, with over 30,000 requests received and 210 kilometers travelled, to date. This article describes the autonomous robot system, the web-based interfaces, and how they communicate with the robot. It highlights lessons learned during this experiment in web-based robotics and includes recommendations for putting future mobile robots on the web. Introduction In December 1995, we began what we assumed would be a short (two to three month) experiment to demonstrate the reliability of a new algorithm that we had developed for autonomous indoor navigation [12]. To provide a continual source of commands to the robot, we set up a web pag...
MABS: Multicast Authentication Based on Batch Signature (2010)

Conventional block-based multicast authentication schemes overlook the heterogeneity of receivers by letting the sender choose the block size, divide a multicast stream into blocks, associate each block with a signature, and spread the effect of the signature across all the packets in the block through hash graphs or coding algorithms. The correlation among packets makes them vulnerable to packet loss, which is inherent in the Internet and wireless networks. Moreover, the lack of Denial of Service (DoS) resilience renders most of them vulnerable to packet injection in hostile environments. In this paper, we propose a novel multicast authentication protocol, namely MABS, including two schemes. The basic scheme (MABS-B) eliminates the correlation among packets and thus provides the perfect resilience to packet loss, and it is also efficient in terms of latency, computation, and communication overhead due to an efficient cryptographic primitive called batch signature, which supports the authentication of any number of packets simultaneously. We also present an enhanced scheme MABS-E, which combines the basic scheme with a packet filtering mechanism to alleviate the DoS impact while preserving the perfect resilience to packet loss.
An Optimal Tilt Integral Derivative Applied to the Regulation of DC Link Voltage in a Stand-Alone Hybrid Energy System (2021)

This paper presents an application of fractional control scheme named Tilt Integral Derivative (TID) to control a stand-alone hybrid energy system composed of a solar photovoltaic (PV) system and a battery bank (BB). A three-level NPC inverter is inserted in order to increase the efficiency of the energy injected into the AC load. Variation in solar radiation or AC load may cause power imbalance, which leads to variation in DC link voltage. As a solution, a buck-boost converter is connected between the DC link and the battery bank to ensures the transfer of energy in both directions. The parameters of TID controller were tuned using a powerful optimization technique known a Genetic Algorithm (GA) by minimizing the Mean Square Error (MSE) used as a performance index. The effectiveness of the proposed TID controller is demonstrated through a comparison with a conventional Proportional-Integral-Derivative (PID) controller, whose parameters are computed by the pidtool function of the Matlab/Simulink tool where the DC link voltage behavior is previously modeled by a capacitor transfer function. The obtained results show that the proposed TID controller provides a stable DC bus with low chattering, regardless of the rapid irradiation and load changes, when compared to a conventional PID controller.