gebhart/patrepeval huggingface dataset:
One-Step Assay for Optical Prostate Specific Antigen Detection Using Magnetically Engineered Responsive Thin Film (2013)

We report a novel and very simple method for the detection of proteolytically-active prostate specific antigen (PSA) at a very low concentration using a self-assembled monolayer (SAM) of magnetic beads conjugated with peptide. The application of surface plasmon resonance (SPR) allows real-time optical characterization of the constructed recognition monolayer. This set-up is also capable of rapid monitoring of PSA samples through an instantaneous detection of medium refractive index shift induced by the enzymatic cleavage of the peptide and the dissociation of free magnetic beads. The results showed the ability of our SPR sensor to detect PSA within a short time (few minutes to 30 min) with high sensitivity (100 pg/ml) and specificity. Thanks to the elimination of washing and blocking steps, as well as the signal amplification and labeling procedures, this approach can be implemented in other miniaturized configurations such as screen printed electrode and biochip array amenable to low-cost point-of-care devices.
Synthesis and Characterization of Kinked and Hyperbranched Carbazole/Fluorene-Based Copolymers (2006)

To decrease the aggregation phenomena and improve the luminescent properties of polyfluorenes (PFs), a series of novel kinked and hyperbranched carbazole units were copolymerized by the Suzuki coupling polycondensation reaction to introduce disorder packing into the copolymer backbones. The thermal, photophysical, electrochemical, and electroluminescent properties of the copolymers were investigated. All of these polymers possess excellent thermal stability with onset decomposition temperatures at 407−466 °C and glass transition temperatures at 109−140 °C. Photoluminescent (PL) studies showed that these polymers were promising blue light-emitting materials, which exhibited high quantum efficiencies in solution and solid states. Long wavelength emissions at 500−600 nm, which were typical for PFs due to their self-aggregation in the solid state, were suppressed in these polymers. Annealing studies under air showed both improved thermal and photoluminescence stability of the polymers. It was proven that HOMO energy levels of the copolymers can be enlarged by increasing the carbazole content in the electrochemical measurements; hence, the hole injection was greatly enhanced. Pure-blue electroluminescence (EL) spectra with narrow fwhm (full width at the half-maximum) values (39−42 nm) and negligible low-energy excimer emission bands were successfully achieved, indicating that these copolymers could be good candidates for blue light-emitting materials.
DISC: A Dynamic Shape Compiler for Machine Learning Workloads (2021)

Many recent machine learning models show dynamic shape characteristics. However, existing AI compiler optimization systems suffer a lot from problems brought by dynamic shape models, including compilation overhead, memory usage, optimization pipeline and deployment complexity. This paper provides a compiler system to natively support optimization for dynamic shape workloads, named DISC. DISC enriches a set of IR to form a fully dynamic shape representation. It generates the runtime flow at compile time to support processing dynamic shape based logic, which avoids the interpretation overhead at runtime and enlarges the opportunity of host-device co-optimization. It addresses the kernel fusion problem of dynamic shapes with shape propagation and constraints collecting methods. This is the first work to demonstrate how to build an end-to-end dynamic shape compiler based on MLIR infrastructure. Experiments show that DISC achieves up to 3.3x speedup than TensorFlow/PyTorch, and 1.8x than Nimble.
Construction (1991)

In the period leading to his conversion, Newman underwent a revolution in his understanding of the nature of orthodoxy. The Apologia (1864) presents this revolution as the collapse and replacement of a paradigm. Its account of 1839–43 describes, in language full of violent and painful images, his anguish as his ‘stronghold’ was demolished: the 1839 brush with Wiseman which ‘pulverised’ the ‘Via Media’ then in 1841 the ‘three blows which broke me’ – the Athanasius translation, Tract go's condemnation, and the farce of the Jerusalem archbishopric, and finally his Anglican ‘deathbed’. By December, 1841, the collapse was complete: the ‘Via Media’ had fallen to pieces ‘and a Theory, made expressly for the occasion, took its place’.
T1-mapping MRT zur Quantifizierung der pulmonalen Inflammation nach endobronchialer Allergenprovokation bei Patienten mit Asthma bronchiale (2012)

Ziele: Entwicklung einer nicht invasiven Methode zur quantitativen Messung pulmonaler Inflammation nach endobronchialer Allergenprovokation mittels T1-mapping Magnetresonanztomographie (MRT). Methode: Sechs Probanden mit allergischem Asthma bronchiale wurden bronchoskopisch in den Segmenten 4/5 rechts und links mit Allergenen provoziert. Es wurden jeweils drei MRT-Untersuchungen (1,5T Avanto, Siemens) vor (0h), 6h und 24h nach Provokation mit einer Inversion Recovery SnapShot fast low-angle shot (FLASH) Sequenz durchgeführt und daraus T1-Karten berechnet. Das Volumen über einem bei T1=1320ms festgelegten Schwellenwert wurde -getrennt nach linker und rechter Lunge- mit der lokalen Konzentration bronchoskopisch gewonnener eosinophiler Granulozyten in der bronchoalveolären Lavage 24h nach Allergenprovokation verglichen. Statistische Auswertung mit Kruskal-Wallis bzw. Wilcoxon-Test sowie Spearman Korrelation. Ergebnis: Über den Beobachtungszeitraum unterschieden sich die mittels der T1-Karten bestimmten Volumina entzündeter Gebiete signifikant voneinander (p=0,01) und waren am Zeitpunkt 6h (Median 288,9 [208,3; 471,9]ml, p=0,007) und 24h (235,2 [137,7; 401,6]ml p=0,02) signifikant erhöht im Vergleich zum Zeitpunkt 0h (43,7 [31,5; 168,5]ml). Ebenso waren die Konzentrationen der Eosinophilen in den Allergen-provozierten Segmenten (13,5 [2,5; 28,1]*104/ml) nach 24h signifikant höher als zum Zeitpunkt 0h (0,009 [0,002; 0,014]*104/ml). Die Volumina der in der MRT T1-Messung nach 6h als entzündet identifizierten Bereiche in der rechten und linken Lunge korrelierten mit der jeweiligen segmentalen Eosinophilenkonzentration 24h nach Provokation (r=0,62, p=0,03). Eine örtliche Übereinstimmung der betroffenen Areale im MRT mit den provozierten Segmenten war vorhanden. Schlussfolgerung: T1-Karten der Lunge eignen sich zur Bestimmung von Stärke und Lokalisation inflammatorischer Veränderungen nach endobronchialer Provokation und stellen damit eine nicht invasive Methode zur Erfassung der pulmonalen Entzündung im zeitlichen Verlauf dar.
[Intraportal injection of specific monoclonal antibody in nude mice with liver metastasis]. (1990)

To assess the importance of monoclonal antibody route of administration, we compared the selective (intraportal) and systemic injection of specific radiolabeled monoclonal antibody, using a murine model of hepatic metastases from a human colorectal carcinoma. Tumor uptake was studied over time after injection of 0.1, 1.0 or 2.0 micrograms of a specific antibody (HT29-15) or an isotype-matched control (BL-3). Significantly higher tumor uptake and tumor/liver or tumor/blood uptake ratios were seen in animals receiving intraportal injection for all tested doses. Intraportal injection of specific monoclonal antibody resulted in significant improvement in metastases uptake; these findings could be applied to the diagnosis and treatment of hepatic metastases from colorectal cancer using radiolabeled monoclonal antibodies.
Copolymer/Clay Nanocomposites for Biomedical Applications (2020)

Abstract Nanoclays still hold a great strength in biomedical nanotechnology applications due to their exceptional properties despite the development of several new nanostructured materials. This article reviews the recent advances in copolymer/clay nanocomposites with a focus on health care applications. In general, the structure of clay comprises aluminosilicate layers separated by a few nanometers. Recently, nanoclay‐incorporated copolymers have attracted the interest of both researchers and industry due to their phenomenal properties such as barrier function, stiffness, thermal/flame resistance, superhydrophobicity, biocompatibility, stimuli responsiveness, sustained drug release, resistance to hydrolysis, outstanding dynamic mechanical properties including resilience and low temperature flexibility, excellent hydrolytic stability, and antimicrobial properties. Surface modification of nanoclays provides additional properties due to improved adhesion between the polymer matrix and the nanoclay, high surface free energy, a high degree of intercalation, or exfoliated morphology. The architecture of the copolymer/clay nanocomposites has great impact on biomedical applications, too, by providing various cues especially in drug delivery systems and regenerative medicine.
Multi-user Interaction with Domestic Lighting Systems (2016)

This PhD research focuses on multi-user interaction in the home environment. In a research-through-design approach, I design and evaluate multi-user interfaces for domestic lighting systems. In this process, I aim to define questions, tools and evaluations methods to support other designers in addressing the multi-user environments in interaction design.
COMMISSION 31: TIME (2010)

Dr R. N. Manchester and Dr M. Hosokawa have been elected as, respectively, the new President and Vice-President of the Commission for the next term, 2009-2012. Concerning the Organizing Committee (OC) Members, we welcome as new members: Felicitas Aris (BIPM, France), Philip Tuckey (LNE-SYRTE, France), Vladimir Zharov (MSU, Russia), and Shougang Zhang (NTSC, China) and we acknowledge the outgoing members: Demetrios Matsakis, Gerard Petit, Mizuhiko Hosokawa, Sigfrid Leschiutta and Zao-Cheng Zhai. P. Defraigne remains on the OC as immediate Past-President.
Site selectivity in self-catalysed functionalization of helical polypeptide structures (1997)

Histidine side chains in helical structures catalyse the acylation of flanking lysine, ornithine and 1,3-diaminobutyric acid residues provided they are in positions i - 3 and i + 4, but not in positions i - 4, i - 1, i + 2, i + 3, relative to a histidine in position i, in a novel site-selective functionalization reaction that enhances the potential of polypeptide and protein design.
A reprogrammable filter bank using CCD discrete analog signal processing (1975)

A multichannel filter using a 32-stage CCD analog shift register (ASR), will be described. The filter uses a recursive two-pole, one-zero network. The center frequencies, bandwidths and gains, are independently programmed using four quadrant multiplying digital-to-analog converters.
QHNS: QoS-aware Hierarchical Name System (2011)

Naming and name resolution mapping are playing extremely important roles in Internet applications. Currently, naming is constructed by the combination of the location of host and the location of resource in the host, and name resolution mapping system is constructed by a tree-like domain name system (DNS). To overcome the shortcomings of DNS, such as not supporting data migration and replication, vulnerable to Denial of Service (DoS) attacks and not supporting quality of service (QoS), researchers have proposed a DHT-based flat structure to achieve naming and name resolution mapping. This system deals with the shortcomings of DNS above very well except supporting QoS, but it introduces a new problem that the resolution time cost is so large that users often can not tolerate this long delay. In this paper, we present an improved structure called QoS-aware Hierarchical Name System (QHNS) by combining the advantages of DNS and DHT. The architecture of QHNS is a two-layer’s structure, namely top-layer which maintains the global information and bottom-layer which maintains local information. Owning to the location information, the resolution delay is greatly reduced while the shortcomings of DNS have been eliminated. And this design can also can do well with the shortcomings of the above two approaches that they can not provide QoS. Finally, theoretical analysis and numerical experiments show that our system is feasible in the practical use.
Spezifische Überexpression von Neuromedin U erhöht die Invasivität durch c-met Regulation beim Pankreaskarzinom Specific overexpression of Neuromedin U enhances invasiveness by c-met regulation in pancreatic cancer (2005)

Neuromedin U is predominantly expressed in the CNS and gastrointestinal tract. Microarray analysis of human tissue specimens of normal pancreas, chronic pancreatitis and pancreatic cancer revealed a cancer-specific overexpression of NmU. Therefore, to investigate the potential of NmU as a diagnostic marker in pancreatic cancer and a putative role of NmU in PDAC pathogenesis were the subject of current investigation. Expression of NmU and its receptors NmUR1 & 2 were characterized in pancreatic cancer cell lines, human pancreatic specimens of normal pancreas, chronic pancreatitis and PDAC by quantitative RT-PCR, immunohistochemistry and Western Blot analysis. An ELISA was used to compare pre- and postoperative NmU serum levels in 10 pancreatic cancer patients and 5 chronic pancreatitis patients. In vitro, effects of NmU on cell proliferation and migration were tested using pancreatic cancer cell lines. A significant overexpression of NmU and NmUR2 mRNA in cancer and metastatic tissues was found by QT-PCR. According to IHC, protein expression was localized predominantly in cancer ducts but also hypertrophic nerves and tubular complexes in primary tumors and in cancer cells of metastasic lesions. Serum levels of NmU were not significantly higher in cancer patients compared to patients suffering from chronic pancreatitis, however individual NmU-serum levels dropped considerably after tumor resection indicating NmU as a possible serum marker for tumor recurrence. No significant effect of exogenous NmU-25 on cell proliferation could be detected. However, NmU treatment promoted rHGF-induced scattering of tumor cells, presumably through an up-regulation of c-met oncogene expression. In conclusion we show that NmU and its receptor NmUR2 are over-expressed in pancreatic cancer on mRNA and on protein level. Besides its role as a clinical marker, we suggest an involvement of NmU in the HGF-Met paracrine loop regulating cell migration and thus invasive tumor growth and dissemination of cancer cells in PDAC. Einleitung Das Neuropeptid Neuromedin U (NmU) wird physiologisch uberwiegend im ZNS und dem Gastrointestinaltrakt exprimiert und spielt eine wichtige Rolle wahrend der Embryogenese. In Microarray Analysen von mikrodissezierten Pankreaskarzinomen war NmU spezifisch in duktalen Adenokarzinomzellen um ein vielfaches uberexprimiert. Daher untersuchten wir die potentielle Anwendung als klinischen Marker sowie die pathophysiologische Rolle von NmU beim duktalen Adenokarzinom des Pankreas.
Carbon Monoxide Levels: Individuals Occupationally Exposedto Vehicle Exhaust (1990)

Using a portable breath carbon monoxide analyser, breath carbon monoxide (CO) of non‐smoking police motorcyclists in central London was found to be consistently elevated in comparison to non‐smoking pedestrians. Although the highest levels were found among smokers, some of the non‐smoking policemen had similar levels to their smoking colleagues. The highest levels among non‐smoking police personnel were found in a group of car mechanics working in a partially enclosed garage. Among the non‐smoking police motorcyclists the highest levels were seen on the day with the highest maximum average hourly ambient CO, the lowest wind speed and the highest air temperature. We conclude that occupational exposure to exhaust fumes leads to elevated levels of breath CO.
Introduction to synthetic polymers (1994)

Part 1 Introduction: definitions and nomenclature some historical perspectives the synthetic polymers industry general features of polymerization processes. Part 2 Average molecular masses and polydispersity: definitions and illustrations experimental determinations liquid-phase osmometry. Part 3 Microscopic features of bulk polymers: general aspects microcrystallinity and drawing amorphous polymers glass transition temperatures melting temperatures measurement of temperatures concluding remarks. Part 4 Major techniques for analysis and structure determination: infrared absorption and spectroscopy nuclear magnetic resonance (NMR) spectroscopy X-ray scattering. Part 5 Step-growth polymerizations: general features linear step-growth systems with two monomers some important linear step-growth polymers network polymers. Part 6 Addition polymerization via free radicals: general features physical forms of synthesis media initiation processes the growth and termination of chains the control of chain growth generation of side-chains. Part 7 Addition polymerization via ionic and co-ordination mechanisms: general features of ionic polymerization cationic polymerization anionic polymerization co-ordination polymerization. Part 8 Properties of common polymers in bulk: crystallinity variation of glass transition temperature drawn thermoplastics elastomers polymer degradation and recycling. Part 9 Some speciality polymers: graft co-polymers and comb co-polymers liquid crystal polymers high-temperature polymers polycarbonate ionomers and polymeric solid electrolytes. Part 10 Looking to the future: the synthesis of block co-polymers side-chain liquid crystals synthetic metals polymers with active surfaces concluding remarks. Appendix: Systematic names of common monomers.
Neuroethics of neuromarketing (2008)

Abstract Neuromarketing is upon us. Companies are springing up to offer their clients brain‐based information about consumer preferences, purporting to bypass focus groups and other marketing research techniques on the premise that directly peering into a consumer's brain while viewing products or brands is a much better predictor of consumer behavior. These technologies raise a range of ethical issues, which fall into two major categories: (1) protection of various parties who may be harmed or exploited by the research, marketing, and deployment of neuromarketing and (2) protection of consumer autonomy if neuromarketing reaches a critical level of effectiveness. The former is straightforward. The latter may or may not be problematic depending upon whether the technology can be considered to so effectively manipulate consumer behavior such that consumers are not able to be aware of the subversion. We call this phenomenon stealth neuromarketing . Academics and companies using neuromarketing techniques should adopt a code of ethics, which we propose here, to ensure beneficent and non‐harmful use of the technology in consideration of both categories of ethics concerns. Copyright © 2008 John Wiley &amp; Sons, Ltd.
Donor T cells lacking Fas ligand and perforin retain the capacity to induce severe GvHD in minor histocompatibility antigen mismatched bone-marrow transplantation recipients (2004)

Graft-versus-host disease (GvHD) is a frequent impediment to therapeutically successful allogeneic bone-marrow transplantation (BMT). This investigation further examines the roles of two potential donor cytotoxic effector mechanisms previously implicated in tissue pathogenesis. Cytotoxically double deficient (B6-cdd) T cells (lacking functional fas ligand and perforin) and wild-type (B6-wt) donor T-cell transplantation in a minor antigen-mismatched BMT model (C57BL/6 --> C3H.SW) resulted in similar mortality and weight loss. Histopathologic findings revealed mononuclear infiltrates and cellular atrophy in GvHD target tissues (liver, stomach) in recipients of B6-wt and B6-cdd donor T cells. Both recipients also exhibited GvH-associated lymphohematopoietic compartment (LHC) alterations as evidenced by inverted CD4:CD8 ratios and B-cell hypoplasia. Notably, transplants using recombinant inbred mHAg disparate recipients demonstrated that B6-cdd T cells induced lethal GvHD in CXBE but not CXBG recipients: the same pattern induced by B6-wt T cells. This observation is consistent with previous findings that cytotoxic T lymphocyte (CTL) responses against CXBG and CXBE antigens did not correlate with GvH responses in these strains. In contrast with the typical pattern of donor T-cell expansion and contraction, T cells lacking perforin and FasL function exhibited extensive expansion postBMT. In summary, these findings support the notion that donor anti-host cytotoxicity by way of the two major pathways is not a prerequisite for induction of GvHD. In addition, the results suggest that this model will be useful to investigate the regulation of allogeneic donor T-cell expansion after major histocompatibility complex-matched allogeneic BMT.
La mesure en rhéologie (2020)

La rhéologie est une spécialité située à l’interface de plusieurs disciplines : la physique, la mécanique des fluides, la mécanique des solides et la physico-chimie de la matière molle. Elle constitue un outil analytique très puissant mais la mise en œuvre et l’analyse des tests expérimentaux qu’elle réalise, soulèvent des problèmes tant théoriques que techniques. Écrit par les meilleurs spécialistes français de la rhéométrie, ce livre couvre la très large diversité des comportements rhéologiques connus, ainsi que la grande variété des outils expérimentaux et théoriques élaborés pour caractériser ces comportements. Il offre un panorama des méthodes utilisées et de la mise en œuvre de la mesure rhéologique, par un éclairage de certaines analyses classiques, mais surtout par une approche des techniques récentes et novatrices. La présentation est concrète et pédagogique en illustrant les différentes analyses par de nombreux exemples empruntés tant au domaine académique qu’industriel. Cet ouvrage de référence s’adresse aux enseignants, aux étudiants (master, doctorat, élèves ingénieurs), aux chercheurs, mais aussi, de par sa recherche de simplicité et de pédagogie, à tout lecteur pratiquant ou susceptible de pratiquer les analyses expérimentales de la rhéologie.
Identification of Acinetobacter baumannii Serum-Associated Antibiotic Efflux Pump Inhibitors (2014)

Adaptive antibiotic resistance is a newly described phenomenon by which Acinetobacter baumannii induces efflux pump activity in response to host-associated environmental cues that may, in part, account for antibiotic treatment failures against clinically defined susceptible strains. To that end, during adaptation to growth in human serum, the organism induces approximately 22 putative efflux-associated genes and displays efflux-mediated minocycline tolerance at antibiotic concentrations corresponding to patient serum levels. Here, we show that in addition to minocycline, growth in human serum elicits A. baumannii efflux-mediated tolerance to the antibiotics ciprofloxacin, meropenem, tetracycline, and tigecycline. Moreover, using a whole-cell high-throughput screen and secondary assays, we identified novel serum-associated antibiotic efflux inhibitors that potentiated the activities of antibiotics toward serum-grown A. baumannii. Two compounds, Acinetobacter baumannii efflux pump inhibitor 1 (ABEPI1) [(E)-4-((4-chlorobenzylidene)amino)benezenesulfonamide] and ABEPI2 [N-tert-butyl-2-(1-tert-butyltetrazol-5-yl)sulfanylacetamide], were shown to lead to minocycline accumulation within A. baumannii during serum growth and inhibit the efflux potential of the organism. While both compounds also inhibited the antibiotic efflux properties of the bacterial pathogen Pseudomonas aeruginosa, they did not display significant cytotoxicity toward human cells or mammalian Ca(2+) channel inhibitory effects, suggesting that ABEPI1 and ABEPI2 represent promising structural scaffolds for the development of new classes of bacterial antibiotic efflux pump inhibitors that can be used to potentiate the activities of current and future antibiotics for the therapeutic intervention of Gram-negative bacterial infections.