gebhart/patrepeval huggingface dataset:
Barbell Technique: A Novel Approach for Bidirectional Bone Augmentation: Technical Note (2020)

Horizontal bone reconstruction is a common augmentation procedure used in implant dentistry to achieve adequate 3-dimensional ridge reconstruction to permit proper dental implant positioning. However, most available techniques are focused on unidirectional bone reconstruction (grafting only on the buccal side). This study was carried out to validate an innovative device that is indicated for bidirectional bone augmentation. The study consisted of 4 patients who required bidirectional horizontal bone augmentation of the upper jaw. Two computerized tomographies were performed (T0 at baseline and T1 at 6 months postoperative examinations). Mean bone thickness in the studied sites at T0 was 2.30 ± 0.65 and mean bone thickness achieved was 9.11 ± 1.08 mm at T1, with an overall bone gain of 6.81 ± 1.33 mm. Concerning the specific gains in direction, buccal and palatal bone augmentations were 4.89 ± 0.94 and 1.92 ± 0.42 mm, respectively. Based on these results, it can be concluded that the use of this novel device allows for the achievement of bidirectional horizontal bone augmentation.
Raspberry Pi based vehicle collision avoidance system (2017)

Vehicle collision avoidance and obstacle detection system is one of the most critical factor in the automotive field. In the present, most of the vehicles enable an alert system which acts as a safety feature for the passengers. In this work, advanced navigation system which detects and avoids the object, is used in autonomous vehicles to safely navigate through the path. This system detects the obstacle in front of the vehicle, alarms the system and moves away. Camera is used for the purpose of detecting moving or stationary objects. The ultrasonic sensor is enclosed with this system to compute the distance of real-time moving and the stationary object. The main work contributes the detection of obstacles ahead of the vehicle. The alarm is given to the system in the vehicle regarding the obstacle in front so that the system helps in collision avoidance. In this work, the distance between the vehicle and obstacle is measured by the ultrasonic sensor and object detection is done by the camera. By fusing both these sensor values the obstacle is detected and the distance is also accurately measured.
Recent Vitamin K Antagonist Use and Intracranial Hemorrhage After Endovascular Thrombectomy for Acute Ischemic Stroke (2023)

Among patients with acute ischemic stroke selected to receive EVT, VKA use within the preceding 7 days was not associated with a significantly increased risk of sICH overall. However, recent VKA use with a presenting INR greater than 1.7 was associated with a significantly increased risk of sICH compared with no use of anticoagulants.
F-0115 Structural Topology Optimization Based On First Order Analysis (2001)

Tools of Computer Aided Engineering (CAE) are widely employed in many mechanical industries such as automotive industries. However, most mechanical design engineers, in fact, do not utilize CAE applications by themselves in the design phase because of the sophisticated operations and a huge amount of time for the analysis. Recently, the concept of a new CAE, First Order Analysis (FOA), has been proposed in order to overcome these problems. In this paper, we present a structural topology optimization method based on this concept. First, a multi-objective optimization problem to deal with the multiple loading problem is formulated. Next, the optimization procedure is developed based on the ground structure approach. Finally, some examples are provided to confirm the optimization method proposed here.
Fremanezumab for Migraine Prevention in Japanese Elderly Aged Over 70 Years Old (2023)

Background Elderly migraine is a public health problem with prolonged life expectancy, and effective prophylactic treatment is needed. There were no reports on fremanezumab for the elderly. We described the real-world data of fremanezumab, calcitonin gene-related peptide-related monoclonal antibody (CGRP-mAB), for migraine in elderly over 70 years old. Methods We retrospectively investigated six elderly migraine patients over 70 years old treated with fremanezumab. Headache impact test-6 (HIT-6), monthly headache days (MHD), and monthly acute medication intake days (AMD) before one and three months after starting fremanezumab treatment were evaluated. Results Three women and three men (median age 78; range: 71-99) were included. One was chronic migraine (CM), three were CM and medication-overuse headache, and two were episodic migraine and tension-type headache. All six patients received monthly fremanezumab. The median MHD before, during one, and three months after treatment were 30 (4-30), 30 (4-30), and 29 (15-30, n=4). Those of AMD were 17 (0-30), 9.5 (0-30), and 1 (0-28). Those about HIT-6 were 64 (56-72), 59.5 (52-70), and 55.5 (48-64). Two (33.3%) of the six patients experienced therapeutic effectiveness. There were no side effects. Conclusion We described the six elderly migraine patients aged over 70 years old treated with fremanezumab. Two (33.3%) of the six patients experienced therapeutic effectiveness. This is the first report of fremanezumab for elderly migraine patients aged over 70 years old. Further evidence accumulation is needed about CGRP-mABs for the elderly.
cAMP stimulates SLC26A3 activity in human colon by a CFTR-dependent mechanism that does not require CFTR activity (2018)

Abstract Background &amp; Aims DRA (SLC26A3) is an electroneutral Cl - /HCO 3 - exchanger that is present in the apical domain of multiple intestinal segments. An area that has continued to be poorly understood is related to DRA regulation in acute cAMP-related diarrheas, in which DRA appears to be both inhibited as part of NaCl absorption and stimulated to contribute to increased HCO 3 - secretion. Different cell models expressing DRA have shown that cAMP inhibits, stimulates or does not affect its activity. Methods This study reevaluated cAMP regulation of DRA using new “tools” including a successful knockout cell model, a specific DRA inhibitor (DRA inh -A250), specific antibodies, and a transport assay that did not rely on non-specific inhibitors. The studies compared DRA regulation in colonoids made from normal human colon with regulation in the colon cancer cell line, Caco-2. Results DRA is an apical protein in human proximal colon, differentiated colonoid monolayers and Caco-2 cells. It is glycosylated and appears as two bands. cAMp(forskolin) acutely stimulated DRA activity in human colonoids and Caco-2 cells. In these cells, DRA is the predominant apical Cl - /HCO 3 - exchanger and is inhibited by DRA inh -A250 with IC 50 of 0.5 μmol/L and 0.2 µ mol/L, respectively. However, there was no effect of cAMP in HEK293/DRA cells that lacked CFTR. When CFTR was expressed in HEK293/DRA cells, cAMP also stimulated DRA activity. In all cases, cAMP stimulation of DRA was not inhibited by CFTR inh -172. Conclusions DRA is acutely stimulated by cAMP by a process that is CFTR-dependent but appears to be one of multiple regulatory effects of CFTR that does not require CFTR activity.
H 2 Is a Major Intermediate in Desulfovibrio vulgaris Corrosion of Iron (2023)

Desulfovibrio vulgaris has been a primary pure culture sulfate reducer for developing microbial corrosion concepts. Multiple mechanisms for how it accepts electrons from Fe<sup>0</sup> have been proposed. We investigated Fe<sup>0</sup> oxidation with a mutant of <i>D. vulgaris</i> in which hydrogenase genes were deleted. The hydrogenase mutant grew as well as the parental strain with lactate as the electron donor, but unlike the parental strain, it was not able to grow on H<sub>2</sub>. The parental strain reduced sulfate with Fe<sup>0</sup> as the sole electron donor, but the hydrogenase mutant did not. H<sub>2</sub> accumulated over time in Fe<sup>0</sup> cultures of the hydrogenase mutant and sterile controls but not in parental strain cultures. Sulfide stimulated H<sub>2</sub> production in uninoculated controls apparently by both reacting with Fe<sup>0</sup> to generate H<sub>2</sub> and facilitating electron transfer from Fe<sup>0</sup> to H<sup>+</sup>. Parental strain supernatants did not accelerate H<sub>2</sub> production from Fe<sup>0</sup>, ruling out a role for extracellular hydrogenases. Previously proposed electron transfer between Fe<sup>0</sup> and <i>D. vulgaris</i> via soluble electron shuttles was not evident. The hydrogenase mutant did not reduce sulfate in the presence of Fe<sup>0</sup> and either riboflavin or anthraquinone-2,6-disulfonate, and these potential electron shuttles did not stimulate parental strain sulfate reduction with Fe<sup>0</sup> as the electron donor. The results demonstrate that <i>D. vulgaris</i> primarily accepts electrons from Fe<sup>0</sup> via H<sub>2</sub> as an intermediary electron carrier. These findings clarify the interpretation of previous <i>D. vulgaris</i> corrosion studies and suggest that H<sub>2</sub>-mediated electron transfer is an important mechanism for iron corrosion under sulfate-reducing conditions. <b>IMPORTANCE</b> Microbial corrosion of iron in the presence of sulfate-reducing microorganisms is economically significant. There is substantial debate over how microbes accelerate iron corrosion. Tools for genetic manipulation have only been developed for a few Fe(III)-reducing and methanogenic microorganisms known to corrode iron and in each case those microbes were found to accept electrons from Fe<sup>0</sup> via direct electron transfer. However, iron corrosion is often most intense in the presence of sulfate-reducing microbes. The finding that Desulfovibrio vulgaris relies on H<sub>2</sub> to shuttle electrons between Fe<sup>0</sup> and cells revives the concept, developed in some of the earliest studies on microbial corrosion, that sulfate reducers consumption of H<sub>2</sub> is a major microbial corrosion mechanism. The results further emphasize that direct Fe<sup>0</sup>-to-microbe electron transfer has yet to be rigorously demonstrated in sulfate-reducing microbes.
Interleaved Self-Oscillating Class E Derived Resonant DC/DC Converters (2012)

A new method for achieving self-oscillating, self-interleaved operation of class E derived resonant DC/DC converters is presented. The proposed method is suitable for operation at frequencies in the Very High Frequency (VHF) band. Interleaved and self-oscillating modes of operation are achieved at the same time with very small number of additional passive components in the interconnection network. To verify the proposed technique, a 110MHz prototype resonant boost converter was designed; experimental results and comparison with SPICE simulation are presented. Peak measured efficiency was 89% in continuous operation.
Towards Sustainable Livestock production in the Netherlands: Outline of a Learning and Experimentation Strategy (LES) (2010)

During the second half of the 20 century, livestock production in the Netherlands evolved in a close national alignment between politics, policy and sector representatives. Main focus was on increasing production efficiency with a strong orientation towards export. Gradually, this modernization process became criticized for its negative side effects. Early criticism emphasized the dangers of chemical pest and weed control, emission of malodors from livestock units and mineral surpluses. Later, emphasis shifted to impaired animal welfare, and to contagious and zoonotic animal diseases, especially after outbreaks of a variety of epidemic animal diseases in the past decade, including classical swine fever, foot and mouth disease, avian Influenza and BSE. Recently, criticism centered on contribution of livestock production to climate change and to excessive claims on natural resources of food production.
Bridging With Extracorporeal Membrane Oxygenation Under the New Heart Allocation System: A United Network for Organ Sharing Database Analysis (2021)

Recipients transplanted following extracorporeal membrane oxygenation bridging to transplantation under the new system achieve greater 180-day survival compared with the old and demonstrate less preoperative comorbidity. Waitlist outcomes have also improved significantly under the new allocation system.
Augmented reality near-eye display using Pancharatnam-Berry phase lenses (2019)

An augmented reality (AR) near-eye display using Pancharatnam-Berry (PB) phase lenses is proposed. PB phase lenses provide different optical effects depending on the polarization state of the incident light. By exploiting this characteristic, it is possible to manufacture an AR combiner with a small form factor and a large numerical aperture value. The AR combiner adopted in the proposed system operates as a convex lens for right-handed circularly polarized light and operates as transparent glass for left-handed circularly polarized light. By merging this combiner with a transparent screen, such as diffuser-holographic optical elements (DHOEs), it is possible to make an AR near-eye display with a small form factor and a wide field of view. In addition, the proposed AR system compensates the chromatic aberration that occurs in PB phase lens by adopting three-layered DHOEs. The operating principle of the proposed system is covered, and its feasibility is verified with experiments and analysis.
Analyses of genome architecture and gene expression reveal novel candidate virulence factors in the secretome of Phytophthora infestans (2010)

This work revealed a remarkably diverse plastic secretome. It illustrates the value of combining genome architecture with comparative genomics to identify novel candidate virulence factors from pathogen genomes.
Silencing of indoleamine 2,3-dioxygenase enhances dendritic cell immunogenicity and antitumour immunity in cancer patients (2013)

Dendritic cells (DCs) are being explored as a therapeutic vaccine for cancers. However, their immunogenic potential is limited by the presence of immunosuppressive factors. Among these factors is the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO). In this study, we have investigated the safety, immunogenicity and clinical response of IDO-silenced DC vaccine in four patients with gynecological cancers. DCs were transfected with IDO small interfering RNA and mRNA encoding human telomerase reverse transcriptase (hTERT) or survivin, two universal tumour antigens. Silencing of IDO in DCs did not affect the expression of the co-stimulatory molecules CD80 and CD86, but enhanced the expression of the CCR7 and CD40 molecules. IDO-silenced DCs showed superior potency to activate allogeneic T cells compared to their IDO-positive counterparts. The immunisation with this novel DC cancer vaccine was well tolerated and all patients developed delayed-type hypersensitivity skin reaction and specific T-cell response against hTERT and survivin tumour antigens. Perhaps most importantly, the immune response seen in the patients was related to objective clinical response. Thus, IDO silencing can enhance the immunogenic function of DCs in vitro and in vivo. Overall, the data provide proof-of-principle that immunisation with IDO-silenced DC vaccine is safe and effective in inducing antitumour immunity.
Low-Temperature Wafer Bonding for MEMS Hermetic Packaging Using Sub-micron Au Particles (2010)

A study of wafer-level hermetic bonding using sub-micron gold particles with a mean diameter of 0.3 μm was conducted at bonding temperatures of 150–200°C with varying bonding pressures in the range of 50–100 MPa. 4.5 mm-square, 10 μm–100 μm-wide sealing line patterns of sub-micron Au particles were formed on glass wafers by means of wafer-level processing using photolithography and a slurry-filling technique. The tensile bond strength was measured with a stud-pull method using 5 mm × 5 mm chips and exhibited as > 20 MPa. A preliminary hermeticity test was performed by immersing the bonded wafer pairs into a low-viscosity liquid and it was confirmed that the sealing lines with widths as thin as 20 μm showed a good sealing property against the liquid. The result demonstrated the feasibility of this low-temperature wafer bonding process using sub-micron Au particles, which could achieve hermetic sealing with absorbing a micron-level surface roughness and/or topography.
Abstract 16535: Angiotensin II Receptor Blocker (ARB) in Combination With Neprilysin Inhibition is Superior to ARB Alone in the Setting of Heart Failure (2017)

Introduction: EntrestoTM (LCZ696) combines valsartan, an angiotensin receptor blocker (ARB), and sacubitril, a neprilysin inhibitor (NEPi). LCZ696 was recently approved for use in heart failure (HF...
Abatement of trichloroethylene using DBD plasma (2014)

Dielectric barrier discharge plasma was used to oxidize trichloroethylene (TCE) in 21% of O 2 in carriers of N 2 and He . The degradation products of TCE were analyzed using gas chromatography mass spectrometry. TCE was decomposed completely at optimum energy density of 260 and 300 J/l for He and N 2 , respectively and its conversion followed zero order reaction. The TCE removal efficiency is decreased in humid air due to interception of reactive intermediates by OH radicals.
Influence of inorganic fullerene‐like WS2 nanoparticles on the thermal behavior of isotactic polypropylene (2007)

Abstract A new family of thermoplastic nanocomposites based on isotactic polypropylene (iPP) and inorganic fullerene‐like tungsten disulfide (IF‐WS 2 ) has been successfully prepared. A very efficient dispersion of IF‐WS 2 material was obtained by mixing in the melted polymer without using modifiers or surfactants. The addition of IF‐WS 2 nanoparticles induces a remarkable enhancement of the thermal stability of iPP, as well as an increase in the crystallization rate of the matrix when compared with pure iPP. The nucleating efficiency of IF‐WS 2 solid lubricant nanoparticles on the α‐phase of iPP reaches very high values (60–70%), the highest values observed hitherto for polypropylene nanocomposites. The incorporation of IF‐WS 2 has also been observed to increase the size and stability of the crystals formed. The melting behavior of the nanocomposites indicates the formation of more perfect crystals as determined by differential scanning calorimetry and time‐resolved synchrotron X‐ray scattering experiments. The new nanocomposites show an increase in the storage modulus with respect to pure iPP measured by dynamic mechanical analysis. © 2007 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 45: 2309–2321, 2007
Research on dynamic characteristics of the cylinder block (2005)

The dynamic characteristics of the cylinder block directly influence the vibration and noise of the internal combustion engine (ICE). Modal analysis of the cylinder block is very helpful for its system identification and performance improvement. This paper refers to a basic study on the experimental and analytical methods for the reduction of resonant vibration in each vibration mode on three cylinder ICE, in the rated engine speed range. In order that the simulation embodies the block dynamic character accurately, a finite element (FE) model of a three cylinder ICE was built in I-DEAS environment and FE modal analysis was carried out numerically. Then experimental modal analysis was performed by the hammering method and the modal parameters (natural frequencies, mode shapes and mode damping factors) were obtained. The tested results were compared with those obtained from FE analysis. The result verifies the FE model. Based on the analysis, reasonable measures of reducing vibration and noise are brought forward.
The effect of synthesis parameters on transport properties of nanostructured bulk thermoelectric p‐type silicon germanium alloy (2012)

Abstract Nanostructured silicon germanium thermoelectric materials prepared by mechanical alloying and sintering method have recently shown large enhancement in figure‐of‐merit, ZT . The fabrication of these structures often involves many parameters whose understanding and precise control is required to attain large ZT . In order to find the optimum parameters for further enhancing the ZT of this material, we have grown and studied both experimentally and theoretically different nanostructured p‐type SiGe alloys. The effect of various parameters of milling process and sintering conditions on the thermoelectric properties of the grown samples were studied. The electrical and thermal properties were calculated using Boltzmann transport equation and were compared with the data of nanostructured and crystalline SiGe. It was found that the thermal conductivity not only depends on the average crystallite size in the bulk material, but also it is a strong function of alloying, porosity, and doping concentration. The Seebeck coefficient showed weak dependency on average crystallite size. The electrical conductivity changed strongly with synthesis parameters. Therefore, depending on the synthesis parameters the figure‐of‐merit reduced or increased by ∼60% compared with that of the crystalline SiGe. The model calculation showed that the lattice part of thermal conductivity in the nanostructured sample makes ∼80% of the total thermal conductivity. In addition, the model calculation showed that while the room temperature hole mean free path (MFP) in the nanostructured sample is dominated by the crystallite boundary scattering, at high temperature the MFP is dominated by acoustic phonon scattering. Therefore, the thermal conductivity can be further reduced by smaller crystallite size without significantly affecting the electrical conductivity in order to further enhance ZT .
Second-Generation Total Synthesis of Haterumalide NA Using B-Alkyl Suzuki–Miyaura Coupling (2008)

Second-generation total synthesis of haterumalide NA, a potent cytotoxic marine macrolide, was achieved by using B-alkyl Suzuki-Miyaura coupling and Nozaki-Hiyama-Kishi coupling as key steps (1.2% in 33 steps). Compared to our first-generation approach, the second-generation synthesis is much improved in the yield of key intermediate.
MSDF-Net: Multi-Scale Deep Fusion Network for Stroke Lesion Segmentation (2019)

Lesion segmentation is of great research interest due to its capability in facilitating accurate stroke diagnosis and surgical planning. Existing deep neural networks, such as U-net, have demonstrated encouraging progress in biomedical image segmentation. Nevertheless, there are still many challenges related to the segmentation of stroke lesions, including dealing with diverse lesion locations, variations in lesion scales, and fuzzy lesion boundaries. In order to address these challenges, this paper proposes a deep neural network architecture denoted as the Multi-Scale Deep Fusion Network (MSDF-Net) with Atrous Spatial Pyramid Pooling (ASPP) for the feature extraction at different scales, and the inclusion of capsules to deal with complicated relative entities. The proposed method is essentially an end-to-end deep encoder-decoder neural network. The cross connection between the encoder and the decoder guarantees the high resolution of the feature mapping. Experimental results on the open-source Anatomical Tracings of Lesions After Stroke (ATLAS) dataset shows that the proposed model achieved a higher evaluating score compared to 5 existing models.
Azimuthal ambiguities in synthetic aperture sonar and synthetic aperture radar imagery (1992)

It is shown that azimuthal ambiguities are not eliminated by the nulls of a sonar (or radar) beam pattern and have a definite influence on image quality. In synthetic aperture systems that are strongly limited in spatial sampling, particularly in ocean borne synthetic aperture sonar (SAS) and spaceborne synthetic aperture radar (SAR), azimuthal ambiguities will corrupt the images unless special measures are taken. These azimuthal aliases may be reduced by emphasizing the centermost portion of the available synthetic aperture length, and deemphasizing the endmost portions. This minimizes the effects from synthetic array elements that most strongly contribute to aliases.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>