gebhart/patrepeval huggingface dataset:
Colorectal cancer screening (1998)

Comprehensive evidence-based guidelines for screening and surveillance for colorectal cancer were published in 1997. Backed by compelling scientific data from recently completed controlled trials and case-control studies, these guidelines recommend annual fecal occult blood test screening plus periodic flexible sigmoidoscopy about every 5 years for asymptomatic, average-risk individuals over 50 years of age. Other screening studies published during the past year refine knowledge about how these screening tests detect early cancer and polyps and assess factors that influence compliance with screening recommendations. Preliminary reports suggest revolutionary new methods of screening that may become clinically feasible in the next millennium.
PAPER 26: IS THERE A BIOMECHANICAL DIFFERENCE BETWEEN COMMERCIALLY AVAILABLE HYBRID EXTERNAL FIXATORS? (2010)

Purpose: The objectives of this project were to compare four commercially available hybrid external fixator systems under multiple loading conditions, and to compare each system to an idealized «rigid» frame to distinguish between motion allowed by the pins and wires and motion allowed by frame deformation. Methods: A mechanical testing investigation was performed using fifteen fiberglass composite tibias (Pacific Research Laboratories, Vashon Island, WA, USA) with a 2 cm proximal metaphyseal gap osteotomy (simulating OTA classification 41-A3.3) to test four hybrid systems (Ace-Fischer, DePuyACE, Warsaw, IN; Hoffmann II, Stryker Howmedica Osteonics, Rutherford, NJ; Synthes Hybrid, Synthes USA, Paoli, PA; EBI DynaFix®, EBI, Parsippany, NJ) and a custom built «rigid» frame. Setting: A biomechanics laboratory using a servohydraulic load frame (MTS Bionix 858, Minneapolis, MN). Measurements were made of the motion produced when loads were applied to the proximal tibia through a custom load plate. Results: The only significant difference between commercial systems was in axial loading where the Ace-Fischer allowed less motion than the other frames. In all cases the «rigid» reference frame allowed significantly less motion than the commercial systems. Approximately 50% of the motion comes from frame deformation and 50% from deformation of the pins and wires. Conclusions/Significance: There are few differences between commercially available hybrid external fixation systems for treating unstable proximal tibia fractures. Approximately half of the motion at the fracture site is due to bending deformation in asymmetric frame designs, which leads to unwanted angular and shear displacements at the fracture site.
Viral Persistence and Chronic Immunopathology in the Adult Central Nervous System following Coxsackievirus Infection during the Neonatal Period (2009)

Coxsackieviruses are significant human pathogens, and the neonatal central nervous system (CNS) is a major target for infection. Despite the extreme susceptibility of newborn infants to coxsackievirus infection and viral tropism for the CNS, few studies have been aimed at determining the long-term consequences of infection on the developing CNS. We previously described a neonatal mouse model of coxsackievirus B3 (CVB3) infection and determined that proliferating stem cells in the CNS were preferentially targeted. Here, we describe later stages of infection, the ensuing inflammatory response, and subsequent lesions which remain in the adult CNS of surviving animals. High levels of type I interferons and chemokines (in particular MCP-5, IP10, and RANTES) were upregulated following infection and remained at high levels up to day 10 postinfection (p.i). Chronic inflammation and lesions were observed in the hippocampus and cortex of surviving mice for up to 9 months p.i. CVB3 RNA was detected in the CNS up to 3 months p.i at high abundance ( approximately 10(6) genomes/mouse brain), and viral genomic material remained detectable in culture after two rounds of in vitro passage. These data suggest that CVB3 may persist in the CNS as a low-level, noncytolytic infection, causing ongoing inflammatory lesions. Thus, the effects of a relatively common infection during the neonatal period may be long lasting, and the prognosis for newborn infants recovering from acute infection should be reexplored.
Calculation of Impurity Pick-up in Direct Solidification (2021)

Subject Condensed Matter Physics Collection: Oxford Scholarship Online
S119 UK HOT-HMV Trial: Acceptability and tolerability of high pressure domiciliary non-invasive ventilation (NIV) in COPD (2011)

<h3>Introduction</h3> Domiciliary NIV in COPD remains controversial with previous randomised controlled trials showing little clinical benefit. However, these trials have been criticised for using low pressure NIV and consequently nocturnal hypoventilation occurs. In contrast, there are genuine concerns that patients may not be able to tolerate the high pressure domiciliary NIV required to manage nocturnal hypoventilation effectively. <h3>Method</h3> Patients admitted for acute hypercapnic respiratory failure due to an exacerbation of COPD with persistent hypercapnia (PaCO<sub>2</sub>&gt;7 kPa) 2–4 weeks following resolution of acute episode were offered participation into the trial. Patients were randomised to either home oxygen therapy (HOT) or home mechanical ventilation (HMV) and followed up at 6 weeks and 3 months. Patient assessment included anthropometrics, arterial blood gases and health related quality of life measures. Sleep disruption was assessed using actigraphy (Actiwatch spectrum, Philips-Respironics, Murrysville, Pennsylvania, USA) for 7 days following the assessment. <h3>Results</h3> 36 patients have been recruited and randomised to date. Abstract S119 table 1 show the baseline data for 20 patients that have completed follow-up to 3 months. Discharge ventilator settings were IPAP 26±3 cmH<sub>2</sub>O, EPAP 5±1 cmH<sub>2</sub>O and back up rate 15±1 bpm in the HMV group. Total sleep time during the first 2 weeks of HMV was significantly shorter than in those patients receiving HOT (?88 min; 95% CI 5 to 172 min, p=0.04). However, by 6 weeks there was no difference between the groups (Δ66 min; 95% CI −62 to 194 min, p=0.3). This was sustained at 3 months (Δ51 min; 95% CI −100 to 202 min, p=0.5). There were no between group differences in wake after sleep onset, sleep efficiency or sleep latency at initial assessment or subsequent follow-up. Ventilator compliance at 6 weeks was 3 h 41 min ±1 h 41 min and at 3 months was 4 h 30 min ±1 h 44 min. <h3>Conclusion</h3> A reduction in total sleep time between patients receiving HMV compared with those receiving HOT was demonstrated during the initial period of acclimatisation to HMV. However, despite increasing ventilator usage during the follow-up period the difference in sleep duration between treatment groups reduced suggesting improved tolerability to NIV.
Safety and early efficacy results from a phase 1, multicenter trial of PSMA-targeted armored CAR T cells in patients with advanced mCRPC. (2022)

94 Background: CART-PSMA-02 is a multi-center, open-label, phase 1 trial evaluating the safety and feasibility of CART-PSMA-TGFβRDN T-cells (PSMA-CART) in patients (pts) with metastatic castration resistant prostate cancer (mCRPC). PSMA-CART are engineered to express a chimeric antigen receptor with specificity to PSMA and a dominant negative form of TGFβRII which renders PSMA-CART resistant to TGFβ-mediated immunosuppression. Herein, preliminary safety and efficacy results from this trial are reported. Methods: This is a 3+3 dose escalation study to determine the recommended phase 2 dose and schedule of PSMA-CART cells following lymphodepleting chemotherapy (LD) with cyclophosphamide and fludarabine. Results: As of October 2021, 9 pts were dosed. Two pts received 1-3x10 7 cells, 4 pts received 1-3x10 8 cells, and 3 pts received 0.7-1x10 8 cells with anakinra prophylaxis. Grade 1-2 CRS was observed in all pts receiving 1-3x10 8 cells and 2/3 pts who received anakinra prophylaxis. No pts developed CRS &gt; G2. Two events of immune-effector cell associated neurotoxicity syndrome (ICANS) were observed (1 G2, 1 G5). Two pts experienced DLTs at dose level of 1-3x10 8 , one of whom developed G5 events of ICANS and multi-organ failure (MOF) after receiving 30% of his fractionated dose (total dose = 0.9x10 8 ). This pt’s clinical course and autopsy findings were consistent with macrophage activation syndrome. The trial continued with a modified dose of 0.7-1x10 8 and the incorporation of prophylactic anakinra (100mg SC daily x7 doses). Another G5 event was observed, likely related to immune toxicity, with ferritin levels peaking at &gt;100,000 ng/mL prior to death. Cause of death on autopsy was equivocal and contributing factors included metastatic prostate cancer, MOF and coagulopathy. Cytokine levels from both pts experiencing G5 events were elevated compared to all other pts (e.g., IL-6, sIL2RA, MIG/CXCL9, MIP1b/CCL4, IP-10/CXCL19, IL2 and IL1b). In pts receiving ≥ 0.9x10 8 cells (n=7), preliminary efficacy results demonstrated stable disease by RECIST v1.1 at day 28 (D28) in 4/5 evaluable pts. Decreases in serum PSA occurred in 4/7 pts with &gt;50% decreases observed in 2/5 evaluable pts at D28. Conclusions: PSMA-CART has shown preliminary evidence of biological activity in the absence of clear indications of on-target/off-tumor toxicity. The exact mechanisms driving the severe immune-mediated toxicities in this study are currently unclear. While this study has been closed to further enrollment, ongoing research efforts are aimed at exploring patient specific factors, tumor microenvironment factors, and the PSMA-CART construct (including both functional components and armored modules) to design future constructs of PSMA-CART that will enhance the efficacy/safety profile and allow for continued study of this novel therapy in the clinic. Clinical trial information: NCT04227275.
Base catalysis in imaging materials. 1. Design and synthesis of novel light-sensitive urethanes as photoprecursors of amines (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleBase catalysis in imaging materials. 1. Design and synthesis of novel light-sensitive urethanes as photoprecursors of aminesJames F. Cameron and Jean M. J. FrechetCite this: J. Org. Chem. 1990, 55, 23, 5919–5922Publication Date (Print):November 1, 1990Publication History Published online1 May 2002Published inissue 1 November 1990https://pubs.acs.org/doi/10.1021/jo00310a028https://doi.org/10.1021/jo00310a028research-articleACS PublicationsRequest reuse permissionsArticle Views1006Altmetric-Citations65LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Alternative electrostatic Green’s function for a long tube (2003)

This note describes an expression for the electrostatic Green’s function in a long conducting tube. The expression allows one to readily compute the potentials and fields at and in the vicinity of the singularity where other methods have difficulty.
Recipient B Cells Are Not Required for Graft-Versus-Host Disease Induction (2010)

Recipient antigen presenting cells (APCs) are required for CD8-mediated graft-versus-host disease (GVHD), and have an important and nonredundant role in CD4-mediated GVHD in mouse major histocompatibility complex-matched allogeneic bone marrow transplantation (alloBMT). However, the precise roles of specific recipient APCs-dendritic cells, macrophages, and B cells-are not well defined. If recipient B cells are important APCs they could be depleted with rituximab, an anti-CD20 monoclonal antibody. On the other hand, B cells can downregulate T cell responses, and consequently, B cell depletion could exacerbate GVHD. Patients with B cell lymphomas undergo allogeneic hematopoietic stem cell transplantation (alloSCT) and many are B-cell-deficient because of prior rituximab. We therefore studied the role of recipient B cells in major histocompatibility complex-matched murine models of CD8- and CD4-mediated GVHD by using recipients genetically deficient in B cells and with antibody-mediated depletion of host B cells. In both CD4- and CD8-dependent models, B cell-deficient recipients developed clinical and pathologic GVHD. However, although CD8-mediated GVHD was clinically less severe in hosts genetically deficient in B cells, it was unaffected in anti-CD20-treated recipients. These data indicate that recipient B cells are not important initiators of GVHD, and that efforts to prevent GVHD by APC depletion should focus on other APC subsets.
Manufacture of TFTR Toroidal Field Coils (1983)

A multi-year development and manufacturing effort was recently completed with the shipment of the last toroidal field (TF) coil for the Tokamak Fusion Test Reactor (TFTR) project. This manufacturing effort required the development and implementation of complex manufacturing processes and controls to assure TF coil integrity. This paper describes the manufacturing processes, tests and controls which were necessary to produce the 4.26 m OD, 22680 Kg copper TF coils for the TFTR.
Abstract 71 (2014)

AMERICAN SOCIETY OF PLASTIC SURGEONS PLASTIC & RECONSTRUCTIVE SURGERY PRS GLOBAL OPEN ASPS EDUCATION NETWORK AMERICAN SOCIETY OF PLASTIC SURGEONS PLASTIC & RECONSTRUCTIVE SURGERY PRS GLOBAL OPEN ASPS EDUCATION NETWORK
Terahertz Imaging of Binary Reflectance with Variational Bayesian Inference (2018)

In this paper, we propose a Bayesian inference approach to extract the binary reflectance pattern of samples from compressed measurements in the terahertz (THz) frequency band. Compared with existing compressed THz imaging methods relying on the sparsity of the reflectance pattern, the proposed Bayesian approach exploits the non-negative binary nature of the reflectance without any assumption on its spatial pattern information and enables a pixel-wise iterative inference approach for fast signal recovery. Numerical evaluation confirms the effectiveness of the proposed approach.
Structural Evidence for Common Ancestry of the Nuclear Pore Complex and Vesicle Coats (2008)

Nuclear pore complexes (NPCs) facilitate nucleocytoplasmic transport. These massive assemblies comprise an eightfold symmetric scaffold of architectural proteins and central-channel phenylalanine-glycine-repeat proteins forming the transport barrier. We determined the nucleoporin 85 (Nup85)*Seh1 structure, a module in the heptameric Nup84 complex, at 3.5 angstroms resolution. Structural, biochemical, and genetic analyses position the Nup84 complex in two peripheral NPC rings. We establish a conserved tripartite element, the ancestral coatomer element ACE1, that reoccurs in several nucleoporins and vesicle coat proteins, providing structural evidence of coevolution from a common ancestor. We identified interactions that define the organization of the Nup84 complex on the basis of comparison with vesicle coats and confirmed the sites by mutagenesis. We propose that the NPC scaffold, like vesicle coats, is composed of polygons with vertices and edges forming a membrane-proximal lattice that provides docking sites for additional nucleoporins.
Applications of sliding scattering centers in feature extraction (2015)

The application of sliding scattering centers induced by reflected waves in feature extraction has been investigated. The scattering center change with the line of sight of radar (LOS) and show distinguished feature in the time-frequency representations (TFR). The time-frequency signatures of the scattering center have been utilized to deduce the geometry and motion parameters of two streamlined targets. Simulation shows that the parameters are estimated with high accuracy. The scattering data used in simulations are computed by the well validated full-wave numerical method (FE-BI-MLFMA), and processed by the reassigned spectrogram (RSP).
REGULATING RADIATION QUALITY AND INTENSITY USING NARROW-BAND LEDS FOR OPTIMIZATION OF SOMATIC EMBRYOGENESIS (2005)

The objectives of this study were to examine and optimize how radiation quality andintensity influenced both the induction and development of somatic embryos from carrot embryogeniccalli using light-emitting diodes (LEDs), which emit precise narrow-band radiation. Somatic embryosinduced from carrot embryogenic calli were exposed for 14 days to red and blue radiation at variouslight intensities. The results pertaining to somatic embryo induction showed that: (1) red radiation at10 mol m-2 s-1 significantly increased the density of total somatic embryos induced from carrot embryogenic calli; (2) lower and higher intensities of red radiation (1 to 5 mol m-2 s-1 and 20 mol m-2 s-1) did not significantly influence the density of induced total somatic embryos; and, (3) increasingthe intensity of blue radiation (up to 20 mol m-2 s-1) appeared to have reduced the density ofinduced total somatic embryos. In regard to somatic embryo development, the results showed that:(1) red radiation (up to 20 mol m-2 s-1) had virtually no effect on the development of the carrotsomatic embryos; and, (2) blue radiation (10 or 20 mol m-2 s-1) exerted positive effects on thedevelopment of the carrot somatic embryos, especially in the globular and heart-shaped stages.
Integrated Google Maps and smooth street view videos for route planning (2010)

In this paper, we provide a system that takes start and end points as the input, and will automatically connect to the Google Maps with Street View to achieve the route planned result and scenery along the route. Finally, it will generate a smooth scenic video from the starting point to the destination, which combines the Google Maps to provide better route recognition to users. The users can watch and interact with the video as if they are driving a car through the planned route. Our system is fully automatic but still provides interaction mechanisms for the users to walk around in the scenic video.
Development of Back Surface Texture for Light Management in Epitaxial Lift Off (ELO) Quantum Dot Solar Cells (2017)

Quantum dot (QD) solar cells with light management allow for increased QD absorption without the need for excessive strain balancing. Single-junction GaAs cells with 10 QD layers are fabricated with back surface reflectors (BSRs) and removed from the substrate by epitaxial lift off. Devices with different BSRs will be compared: a flat mirror, a periodic texture that varies in one dimension, a periodic texture that varies in two dimensions, and a random texture achieved by crystallographic etch. Initial results show a 40% increase in sub-band current when comparing devices with a 1-D texture to the flat mirror. The final paper will present development and device results from the other two BSR types.
Augmented Informative Cooperative Perception. (2021)

Connected vehicles, whether equipped with advanced driver-assistance systems or fully autonomous, are currently constrained to visual information in their lines-of-sight. A cooperative perception system among vehicles increases their situational awareness by extending their perception ranges. Existing solutions imply significant network and computation load, as well as high flow of not-always-relevant data received by vehicles. To address such issues, and thus account for the inherently diverse informativeness of the data, we present Augmented Informative Cooperative Perception (AICP) as the first fast-filtering system which optimizes the informativeness of shared data at vehicles. AICP displays the filtered data to the drivers in augmented reality head-up display. To this end, an informativeness maximization problem is presented for vehicles to select a subset of data to display to their drivers. Specifically, we propose (i) a dedicated system design with custom data structure and light-weight routing protocol for convenient data encapsulation, fast interpretation and transmission, and (ii) a comprehensive problem formulation and efficient fitness-based sorting algorithm to select the most valuable data to display at the application layer. We implement a proof-of-concept prototype of AICP with a bandwidth-hungry, latency-constrained real-life augmented reality application. The prototype realizes the informative-optimized cooperative perception with only 12.6 milliseconds additional latency. Next, we test the networking performance of AICP at scale and show that AICP effectively filter out less relevant packets and decreases the channel busy time.
Regulatory control of DNA end resection by Sae2 phosphorylation (2018)

DNA end resection plays a critical function in DNA double-strand break repair pathway choice. Resected DNA ends are refractory to end-joining mechanisms and are instead channeled to homology-directed repair. Using biochemical, genetic, and imaging methods, we show that phosphorylation of Saccharomyces cerevisiae Sae2 controls its capacity to promote the Mre11-Rad50-Xrs2 (MRX) nuclease to initiate resection of blocked DNA ends by at least two distinct mechanisms. First, DNA damage and cell cycle-dependent phosphorylation leads to Sae2 tetramerization. Second, and independently, phosphorylation of the conserved C-terminal domain of Sae2 is a prerequisite for its physical interaction with Rad50, which is also crucial to promote the MRX endonuclease. The lack of this interaction explains the phenotype of rad50S mutants defective in the processing of Spo11-bound DNA ends during meiotic recombination. Our results define how phosphorylation controls the initiation of DNA end resection and therefore the choice between the key DNA double-strand break repair mechanisms.
Associative memory realized by a reconfigurable memristive Hopfield neural network (2015)

Although synaptic behaviours of memristors have been widely demonstrated, implementation of an even simple artificial neural network is still a great challenge. In this work, we demonstrate the associative memory on the basis of a memristive Hopfield network. Different patterns can be stored into the memristive Hopfield network by tuning the resistance of the memristors, and the pre-stored patterns can be successfully retrieved directly or through some associative intermediate states, being analogous to the associative memory behaviour. Both single-associative memory and multi-associative memories can be realized with the memristive Hopfield network.
Detection and quantification of Lyme spirochetes using sensitive and specific molecular beacon probes (2009)

The high sensitivity and specificity of molecular beacons makes them superior probes for the detection of small numbers of B. burgdorferi. Furthermore, the use of molecular beacons can be expanded for the simultaneous detection and quantification of multiple pathogens in the infected hosts, including humans, and in the arthropod vectors.