gebhart/patrepeval huggingface dataset:
Effect of interventions on prescribing of antimicrobials for prophylaxis in obstetric and gynecologic surgery (1989)

The effect of interventions on the conformity of physicians with guidelines for the appropriate use of antimicrobial prophylaxis in obstetric and gynecologic surgery is reported. Guidelines on the appropriate use of antimicrobial prophylaxis in common obstetric and gynecologic surgical procedures were developed in late 1986 by the antibiotic subcommittee at a 1100-bed tertiary-care teaching facility. The guidelines were not adopted immediately by the department of obstetrics and gynecology (OB-GYN). An audit of the medical records of women who had received antimicrobial therapy for abdominal and vaginal hysterectomies and emergency cesarean sections during January through March 1987 showed that cefoxitin was used in 68% of the cases instead of the less expensive and equally efficacious cefazolin as recommended in the guidelines. The projected annual cost of this nonconformity was $26,500. After the subcommittee informed the physicians about the guidelines and the audit results, the OB-GYN department adopted the guidelines. A second audit performed one year later showed that cefazolin was used in the recommended manner in 93% of cases; projected annual cost savings were $25,000. Both audits showed that prophylactic treatment was inappropriately prolonged in 6% of cases. Substantial cost savings were realized by minimizing inappropriate antimicrobial drug use through efforts to promote rational and cost-effective therapy.
Generation of Soluble Advanced Glycation End Products Receptor (sRAGE)-Binding Ligands during Extensive Heat Treatment of Whey Protein/Lactose Mixtures Is Dependent on Glycation and Aggregation (2016)

Heating of protein- and sugar-containing materials is considered the primary factor affecting the formation of advanced glycation end products (AGEs). This study aimed to investigate the influence of heating conditions, digestion, and aggregation on the binding capacity of AGEs to the soluble AGE receptor (sRAGE). Samples consisting of mixtures of whey protein and lactose were heated at 130 °C. An in vitro infant digestion model was used to study the influence of heat treatment on the digestibility of whey proteins. The amount of sRAGE-binding ligands before and after digestion was measured by an ELISA-based sRAGE-binding assay. Water activity did not significantly affect the extent of digestibility of whey proteins dry heated at pH 5 (ranging from 3.3 ± 0.2 to 3.6 ± 0.1% for gastric digestion and from 53.5 ± 1.5 to 64.7 ± 1.1% for duodenal digestion), but there were differences in cleavage patterns of peptides among the samples heated at different pH values. Formation of sRAGE-binding ligands depended on the formation of aggregates and was limited in the samples heated at pH 5. Moreover, the sRAGE-binding activity of digested sample was changed by protease degradation and correlated with the digestibility of samples. In conclusion, generation of sRAGE-binding ligands during extensive heat treatment of whey protein/lactose mixtures is limited in acidic heating condition and dependent on glycation and aggregation.
Lipid Binding by Disordered Proteins (2013)

Intrinsically disordered proteins \(IDPs) play important roles in a multitude of biological process, especially in the regulation of signal transduction pathways. Many IDPs are implicated in several diseases such as cancer, diabetes, neurodegenerative diseases and others. We have developed a detailed protocol for purifying the intrinsically disordered Unique domain of the human non-receptor tyrosine kinase c-Src. Moreover, here we introduce two additional techniques that have been used to assess the capability of the protein to binding lipids: a simple protein-lipid assay \(Echelon Lipid Strip TM ) and a NMR approach where we have observed the unfolded Unique domain of c-Src in the presence of different types of bicelles.
Total hip arthroplasty in protrusio acetabuli of rheumatoid arthritis. (1980)

Thirty-five total hip arthroplasties done in twenty-five patients with protrusio acetabuli secondary to rheumatoid arthritis were reviewed. There was an average follow-up of 4.3 years, with a range of three to seven years. The results were rated as excellent or good in 66 per cent, fair in 26 per cent, and poor in 8 per cent. Although 100 per cent demonstrated cementbone interface demarcation around the acetabular component, only 10 per cent showed progression of the line of demarcation to two millimeters and one had acetabular loosening with migration. Eight per cent showed femoral loosening or subsidence; 8 per cent, calcar resorption; and 6 per cent, a receding cortex with cystic changes. Twenty-three per cent had nonunion of the greater torchanter after trochanteric osteotomy. Type-III cement-bone interface demarcation was present around the acetabular component was positioned one centimeter superiorly or medially beyond the anatomical position, as estimated by the method described. In thirteen hips in which the acetabular component was positioned within five millimeters of the anatomical position, no Type-III demarcation was present. Better fixation and position of the acetabular component is achieved by the use of a bone graft or a special titanium perforated-sheet mesh, or both, or by an acetabular shell. The use of three wires improved trochanteric fixation.
Carboxylate-Assisted Ruthenium-Catalyzed Alkyne Annulations by C–H/Het–H Bond Functionalizations (2013)

To improve the atom- and step-economy of organic syntheses, researchers would like to capitalize upon the chemistry of otherwise inert carbon-hydrogen (C-H) bonds. During the past decade, remarkable progress in organometallic chemistry has set the stage for the development of increasingly viable metal catalysts for C-H bond activation reactions. Among these methods, oxidative C-H bond functionalizations are particularly attractive because they avoid the use of prefunctionalized starting materials. For example, oxidative annulations that involve sequential C-H and heteroatom-H bond cleavages allow for the modular assembly of regioselectively decorated heterocycles. These structures serve as key scaffolds for natural products, functional materials, crop protecting agents, and drugs. While other researchers have devised rhodium or palladium complexes for oxidative alkyne annulations, my laboratory has focused on the application of significantly less expensive, yet highly selective ruthenium complexes. This Account summarizes the evolution of versatile ruthenium(II) complexes for annulations of alkynes via C-H/N-H, C-H/O-H, or C-H/N-O bond cleavages. To achieve selective C-H bond functionalizations, we needed to understand the detailed mechanism of the crucial C-H bond metalation with ruthenium(II) complexes and particularly the importance of carboxylate assistance in this process. As a consequence, our recent efforts have resulted in widely applicable methods for the versatile preparation of differently decorated arenes and heteroarenes, providing access to among others isoquinolones, 2-pyridones, isoquinolines, indoles, pyrroles, or α-pyrones. Most of these reactions used Cu(OAc)2·H2O, which not only acted as the oxidant but also served as the essential source of acetate for the carboxylate-assisted ruthenation manifold. Notably, the ruthenium(II)-catalyzed oxidative annulations also occurred under an ambient atmosphere of air with cocatalytic amounts of Cu(OAc)2·H2O. Moreover, substrates displaying N-O bonds served as "internal oxidants" for the syntheses of isoquinolones and isoquinolines. Detailed experimental mechanistic studies have provided strong support for a catalytic cycle that relies on initial carboxylate-assisted C-H bond ruthenation, followed by coordinative insertion of the alkyne, reductive elimination, and reoxidation of the thus formed ruthenium(0) complex.
Synthesis of three-dimensional light fields with binary spatial light modulators (2011)

Computation of a binary spatial light modulator (SLM) pattern that generates a desired light field is a challenging quantization problem for which several algorithms have been proposed, mainly for far-field or Fourier plane reconstructions. We study this problem assuming that the desired light field is synthesized within a volumetric region in the non-far-field range after free space propagation from the SLM plane. We use Fresnel and Rayleigh-Sommerfeld scalar diffraction theories for propagation of light. We show that, when the desired field is confined to a sufficiently narrow region of space, the ideal gray-level complex-valued SLM pattern generating it becomes sufficiently low pass (oversampled) so it can be successfully halftoned into a binary SLM pattern by solving two decoupled real-valued constrained halftoning problems. Our simulation results indicate that, when the synthesis region is considered, the binary SLM is indistinguishable from a lower resolution full complex gray-level SLM. In our approach, free space propagation related computations are done only once at the beginning, and the rest of the computation time is spent on carrying out standard image halftoning.
Ocular Findings in Arthrogryposis Multiplex Congenita (1982)

Close ophthalmological follow-up of a case of arthrogryposis multiplex congenita disclosed a progressing paresis of the lateral recti, a gradual decrease in the corneal blinking reflex by the age of eight weeks and a clear deterioration of the visual evoked responses by the first 16 weeks of life along with preservation of normal ERG responses. These observations are believed to represent the gradual affection of the motor and sensorial cranial nerves occurring post-natally in this case of AMC.
'Batterie primarie (non ricaricabili) e secondarie (ricaricabili) a base di elettroliti polimerici basati su ioni magnesio', brevetto italiano depositato il 29-07-1999 (1999)

FIELD: primary and secondary batteries using magnesium-containing anode. \n SUBSTANCE: proposed battery has at least one anode, at least one cathode, at least one electrolyte, and current collectors; at least anode of mentioned batteries is magnesium based and optionally cathode and electrolyte may also contain magnesium. These batteries provide for obtaining separate components and for introducing thin layer of magnesium base electrolyte between anode and cathode. \n EFFECT: enhanced performance characteristics, reduced cost.
Diethylaluminum Cyanide (2001)

[5804-85-3] C5H10AlN (MW 111.12) InChI = 1S/2C2H5.CN.Al/c3*1-2;/h2*1H2,2H3;; InChIKey = KWMUAEYVIFJZEB-UHFFFAOYSA-N (hydrocyanation of α,β-unsaturated ketones;2 preparation of α-cyanohydrins from carbonyl compounds3) Physical Data: bp 162 °C/0.02 mmHg; colorless syrup; exists as a tetra- or pentamer in boiling benzene or diisopropyl ether and as a dimer in boiling THF. Solubility: sol benzene, toluene, diisopropyl ether. Form Supplied in: solution in toluene. Preparative Method: by reaction of Triethylaluminum with a slight excess of Hydrogen Cyanide below rt.1 Handling, Storage, and Precautions: highly toxic. It can be stored as 1–2 M solutions in benzene, toluene, or diisopropyl ether. Use in a fume hood.
Authorization recycling in hierarchical RBAC systems (2011)

As distributed applications increase in size and complexity, traditional authorization architectures based on a dedicated authorization server become increasingly fragile because this decision point represents a single point of failure and a performance bottleneck. Authorization caching, which enables the reuse of previous authorization decisions, is one technique that has been used to address these challenges. This article introduces and evaluates the mechanisms for authorization “recycling” in RBAC enterprise systems. The algorithms that support these mechanisms allow making precise and approximate authorization decisions, thereby masking possible failures of the authorization server and reducing its load. We evaluate these algorithms analytically as well as using simulation and a prototype implementation. Our evaluation results demonstrate that authorization recycling can improve the performance of distributed-access control mechanisms.
Software tools for ISO 9000 certification (1999)

This paper reports the findings of a survey on 24 commercial tools for ISO 9000 certification. We analyse these tools along several dimensions: certification stages supported, targeted industry sectors, and features. Each tool typically provides assistance for several stages of the certification process. Most tools provide some kinds of support for the system analysis, system implementation, system review and maintenance stages. As expected, many tools (about 33 per cent) are targeted specifically for the manufacturing sector. Another 60 per cent of the tools aim at the general business sector. Sixty per cent of the tools support assessment activities while about half support documentation template. No single tool covers all activities of the certification process. It is recommended that any company which is planning or is in the process of implementing a QMS should seriously consider the opportunity of using some of these automated tools.
X-ray lasers (1990)

The first in its field, this book is both an introduction to x-ray lasers and a how-to guide for specialists. It provides new entrants and others interested in the field with a comprehensive overview and describes useful examples of analysis and experiments as background and guidance for researchers
A case-control study of HIV-1–related dementia and co-infection with HHV-8 (2002)

This nested case-control study assessed the putative protective effect of human herpesvirus-8 (HHV-8) against HIV-1-related dementia (dementia). The HHV-8 seropositivity of 210 male age- and HIV disease stage-matched cases and controls was compared. The overall HHV-8 seropositivity of 66% was similar among demented HIV-infected cases and nondemented HIV-infected controls.
Mechanosensory responses of osteocytes to physiological forces occur along processes and not cell body and require α V β 3 integrin (2013)

Osteocytes in the lacunar-canalicular system of the bone are thought to be the cells that sense mechanical loading and transduce mechanical strain into biomechanical responses. The goal of this study was to evaluate the extent to which focal mechanical stimulation of osteocyte cell body and process led to activation of the cells, and determine whether integrin attachments play a role in osteocyte activation. We use a novel Stokesian fluid stimulus probe to hydrodynamically load osteocyte processes vs. cell bodies in murine long bone osteocyte Y4 (MLO-Y4) cells with physiological-level forces <10 pN without probe contact, and measured intracellular Ca(2+) responses. Our results indicate that osteocyte processes are extremely responsive to piconewton-level mechanical loading, whereas the osteocyte cell body and processes with no local attachment sites are not. Ca(2+) signals generated at stimulated sites spread within the processes with average velocity of 5.6 μm/s. Using the near-infrared fluorescence probe IntegriSense 750, we demonstrated that inhibition of αVβ3 integrin attachment sites compromises the response to probe stimulation. Moreover, using apyrase, an extracellular ATP scavenger, we showed that Ca(2+) signaling from the osteocyte process to the cell body was greatly diminished, and thus dependent on ATP-mediated autocrine signaling. These findings are consistent with the hypothesis that osteocytes in situ are highly polarized cells, where mechanotransduction occurs at substrate attachment sites along the processes at force levels predicted to occur at integrin attachment sites in vivo. We also demonstrate the essential role of αVβ3 integrin in osteocyte-polarized mechanosensing and mechanotransduction.
Organolithium Compounds with Hydroxyl, Nitrilo and Sulfonamido Groups (1948)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOrganolithium Compounds with Hydroxyl, Nitrilo and Sulfonamido GroupsHenry Gilman and Donald S. MelstromCite this: J. Am. Chem. Soc. 1948, 70, 12, 4177–4179Publication Date (Print):December 1, 1948Publication History Published online1 May 2002Published inissue 1 December 1948https://pubs.acs.org/doi/10.1021/ja01192a058https://doi.org/10.1021/ja01192a058research-articleACS PublicationsRequest reuse permissionsArticle Views432Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effect of sugars and metabolic intermediates on the attachment of Treponema pallidum to rabbit cells (1984)

The effect of various energy sources and metabolic intermediates on the attachment of Treponema pallidum to baby rabbit genital organ (BRGO) cells in culture was examined. Pyruvate and glucose enhanced the motility of T. pallidum in vitro. Pyruvate increased significantly the attachment of treponemes to BRGO cells when compared with the other substrates but all substrates tested stimulated DNA synthesis by cultured BRGO cells. Thus, the effect of pyruvate on attachment may be due to an effect on the treponemes. Prior exposure of the BRGO cells to the glucose analogue 2-deoxyglucose greatly inhibited the attachment of T. pallidum whereas three other analogues had no effect. The inhibitory effect of 2-deoxyglucose was partially reversed by the presence of pyruvate in the attachment assay. These results suggest that energy metabolism of both T. pallidum and host cells may be required for the initial interaction of T. pallidum with its host in vivo.
Throughput and Latency in Finite-Buffer Line Networks (2011)

This work investigates the effect of finite buffer sizes on the throughput capacity and packet delay of line networks with packet erasure links that have perfect feedback. These performance measures are shown to be linked to the stationary distribution of an underlying irreducible Markov chain that models the system exactly. Using simple strategies, bounds on the throughput capacity are derived. The work then presents two iterative schemes to approximate the steady-state distribution of node occupancies by decoupling the chain to smaller queueing blocks. These approximate solutions are used to understand the effect of buffer sizes on throughput capacity and the distribution of packet delay. Using the exact modeling for line networks, it is shown that the throughput capacity is unaltered in the absence of hop-by-hop feedback provided packet-level network coding is allowed. Finally, using simulations, it is confirmed that the proposed framework yields accurate estimates of the throughput capacity and delay distribution and captures the vital trends and tradeoffs in these networks.
Highly durable spray layer-by-layer assembled films (2012)

Despite the efforts to improve the mechanical durability of layer-by-layer assembled films, abrasion resistance for functional surface applications remains challenging. The authors demonstrate a novel method for significantly improving the abrasion resistance of nanoporous, spray layer-by-layer films by introducing a reinforcing solution containing a sol-gel precursor. The extent of reinforcement depended on the morphology of the film, precursor content in the solution and pretreatment steps. Because both porous films based on silicon dioxide and titanium dioxide nanoparticles were successfully reinforced, the authors combined the materials to create a two-stack antireflection film with significant abrasion resistance while maintaining the desired optical properties. While the fundamental mechanism of reinforcement is not fully understood, the authors have heuristically highlighted the parameters whereby the technique is extensible to other nanoporous systems.
Enantioselective Synthesis of Both Enantiomers of 7,7-Dimethyl-6,8-dioxa-bicyclo[3.2.1]octane via Regioselective Asymmetric Dihydroxylation (1993)

The enantiomers of 7,7-dimethyl-6,8-dioxabicyclo-[3.2.1]octane were prepared in two steps from 7-methyl-1,6-octadiene.
Fuel Flexibility Test Campaign on a GE10 Gas Turbine: Experimental and Numerical Results (2006)

Medium- and low-LHV fuels are receiving a continuously growing interest in stationary power applications. Besides that, since in many applications the fuels available at a site can be time by time of significantly different composition, fuel flexibility has become one of the most important requirements to be taken into account in developing power systems. A test campaign, aimed to provide a preliminary assessment of a small power gas turbine’s fuel flexibility, was carried over a full-scale GE10 prototypical unit, located at the Nuovo-Pignone manufacturing site, in Florence. The engine is a single shaft, simple cycle gas turbine designed for power generation applications, rated at 11 MW electrical power and equipped with a silos-type combustor. A variable composition gas fuel was obtained by mixing natural gas with CO2 to about 40% by vol. at engine base-load condition. Tests involved two different diffusive combustion systems: the standard version, designed for operation with natural gas, and a specific system designed for low-LHV fuels. Tests performed aimed to investigate both ignition limits and combustors’ performances, focusing on hot parts’ temperatures and pollutant emissions. Regarding NOx emissions, data collected during standard combustor’s tests were matched a simple scaling law (as a function of cycle parameters and CO2 concentration in the fuel mixture), which can be used in similar applications as a NOx predictive tool. In a following step, a CFD study was performed in order to verify in detail the effects of LHV reduction on flame structure and to compare measured and calculated NOx. STAR-CD™ code was employed as main CFD solver while turbulent combustion and NOx models were specifically developed and implemented using STAR’s user-subroutine features. Both models are based on classical laminar-flamelet approach. Three different operating points were considered at base-load conditions, varying CO2 concentration (0%, 20% and 30% vol. simulated). Numerical simulations point out the flexibility of the GE10 standard combustor to assure flame stabilization even against large variation of fuel characteristics. Calculated NOx emissions are in fairly good agreement with measured data confirming the validity of the adopted models.