gebhart/patrepeval huggingface dataset:
Elastographie: Quantitative Bildgebung der elastischen Gewebeeigenschaften (2003)

The wide range of elastic tissue properties and the difference in elasticity of tumors and the adjacent tissues have provided motivation for developing elasticity imaging techniques. These research efforts have converged with the development of a new imaging modality, the so-called elastography, with the acquired and processed images referred to as elastograms. This modality was pioneered for ultrasonic imaging, which provides the majority of experience on this topic. MR-elastography has been developed in recent years. The published clinical data range from the characterization of prostate and breast cancer in oncology and dynamic examinations of skeletal muscle to intravascular elastic differentiation of vessel plaques. Advantages of the ultrasonic elastography are ubiquitous applicability and cost-effectiveness. MR elastography offers improved reconstruction and the possibility to assess potential anisotropic properties. The different approaches of elastography, their technical and clinical application and the limitations known so far are reviewed in this paper.
The Water Drinking Test (1967)

Rise in intraocular pressure following an oral water load has previously been thought to be a consequence of osmotic changes, water moving from the diluted blood into the less dilute aqueous. The present study of 234 water drinking tests demonstrates that osmotic considerations alone are not an entirely adequate explanation. Increase in intraocular pressure precedes decrease in serum osmolality in 20% of the cases. Intraocular pressure rises so rapidly following ingestion of water that a testing technique must be used in which pressure is measured at least every 15 minutes after drinking the water. In the present series, if a single measurement had been made one hour after drinking, the peak intraocular pressure would have been missed in 97% of the cases.
An EWS-FLI1-Induced Osteosarcoma Model Unveiled a Crucial Role of Impaired Osteogenic Differentiation on Osteosarcoma Development (2016)

EWS-FLI1, a multi-functional fusion oncogene, is exclusively detected in Ewing sarcomas. However, previous studies reported that rare varieties of osteosarcomas also harbor EWS-ETS family fusion. Here, using the doxycycline-inducible EWS-FLI1 system, we established an EWS-FLI1-dependent osteosarcoma model from murine bone marrow stromal cells. We revealed that the withdrawal of EWS-FLI1 expression enhances the osteogenic differentiation of sarcoma cells, leading to mature bone formation. Taking advantage of induced pluripotent stem cell (iPSC) technology, we also show that sarcoma-derived iPSCs with cancer-related genetic abnormalities exhibited an impaired differentiation program of osteogenic lineage irrespective of the EWS-FLI1 expression. Finally, we demonstrate that EWS-FLI1 contributed to secondary sarcoma development from the sarcoma iPSCs after osteogenic differentiation. These findings demonstrate that modulating cellular differentiation is a fundamental principle of EWS-FLI1-induced osteosarcoma development. This in vitro cancer model using sarcoma iPSCs should provide a unique platform for dissecting relationships between the cancer genome and cellular differentiation.
Immediately loaded machined versus rough surface dental implants in edentulous jaws: One-year postloading results of a pilot randomised controlled trial. (2015)

Up to 1 year after immediate loading, both implant surfaces provided good and similar results, however, the only two implants which failed early in the same patient had a machined surface. These preliminary results must be confirmed by larger trials with longer follow-ups.
Methyl and Fluorine Effects in Novel Orally Bioavailable Keap1–Nrf2 PPI Inhibitor (2023)

Oxidative stress is one of the causes of progression of chronic kidney disease (CKD). Activation of the antioxidant protein regulator Nrf2 by inhibition of the Keap1-Nrf2 protein-protein interaction (PPI) is of interest as a potential treatment for CKD. We report the identification of the novel and weak PPI inhibitor <b>7</b> with good physical properties by a high throughput screening (HTS) campaign, followed by structural and computational analysis. The installation of only methyl and fluorine groups successfully provided the lead compound <b>25</b>, which showed more than 400-fold stronger activity. Furthermore, these dramatic substituent effects can be explained by the analysis of using isothermal titration calorimetry (ITC). Thus, the resulting <b>25</b>, which exhibited high oral absorption and durability, would be a CKD therapeutic agent because of the dose-dependent manner for up-regulation of the antioxidant protein heme oxigenase-1 (HO-1) in rat kidneys.
Chemicals from textiles to skin: an in vitro permeation study of benzothiazole (2018)

Despite the possible impact on human health, few studies have been conducted to assess the penetration and accumulation of contaminants in the skin after a prolonged contact with textile materials. In previous studies, we have shown that benzothiazole and its derivatives, as well as other potentially hazardous chemicals, often are present as textile contaminants in clothes available on the retail market. Since benzothiazole is a common contaminant in clothes, these can be a possible route for human chemical exposure, both systemic and onto the skin. To investigate this potential exposure, Franz-type and flow-through cells were used for the permeation studies together with a Strat-M® artificial membranes. Experiments were performed using solutions of benzothiazole, as well as contaminated textile samples in the donor chamber. Benzothiazole was demonstrated to penetrate through, as well as being accumulated in the membrane mimicking the skin. After 24 h, up to 62% of benzothiazole was found in the acceptor cell, while up to 37% was found absorbed in the skin mimicking membrane. It also was shown that there was release and permeation from contaminated fabrics. The results indicate that benzothiazole can be released from textile materials, penetrate through the skin, and further enter the human body. This will possibly also apply to other chemical contaminants in textiles, and the results of this study indicate that the presence of these textile contaminants entails potential health risks. A rough risk assessment was made for clothing textiles according to Environmental Protection Agency (EPA) and European regulations for carcinogenic and non-carcinogenic compounds, using literature data for benzothiazole.
Changes in Treatment Outcomes of Gastric Cancer Surgery Over 45 Years at A Single Institution (2008)

Treatment results of gastric cancer surgery have improved remarkably over the 45-year period. Increase of early stage gastric cancer with early diagnosis considerably influenced the improved survival of patients with gastric cancer.
The effects of in utero exposure of lambs to a beta-adrenergic agonist on prenatal and postnatal muscle growth, carcass cutability, and meat tenderness. (1995)

The objectives of the present experiment were to examine the effects of in utero exposure to a beta-adrenergic agonist (L644,969) on prenatal and postnatal muscle growth and meat tenderness of lambs. Thirty twin-pregnant Composite IV (1/2 Finnsheep, 1/8 Dorset, 1/8 Rambouillet, 1/8 Targhee, 1/8 Suffolk) ewe lambs were used for this experiment. All ewes were fed an alfalfa hay-corn-based diet throughout gestation and lactation. From d 25 to 95 of gestation, the diet of one-half of the ewes contained 2 ppm of L644,969 on an as-fed basis. Treatment did not ( P > .05) affect lamb weights at any point in the growth cycle (birth to 43 kg). Heart weights of neonatal and market lambs were increased ( P < .05) by in utero exposure to L644,969. However, weights of lamb carcass components and weights of individual muscles were not affected by treatment (P > .05). Additionally, treatment did not alter the activities of any of the components of the calpain proteolytic system in neonatal or market lambs. Concomitantly, there was no effect of treatment on myofibril fragmentation index or Warner-Bratzler shear force. Moreover, there was no effect of treatment on muscle fiber type distributions, fiber sizes, or apparent fiber number. It seems that the lack of an effect of treatment on apparent fiber number would explain the lack of an effect on muscle weight. Thus, in utero exposure to L644,969 does not seem to have promise as a method for improving lamb carcass cutability. Other methods of improving the rate and composition of lamb carcass growth while maintaining acceptable meat tenderness must be developed.
Signal Processing Aspects of Cell-Free Massive MIMO (2018)

The fifth generation of mobile communication systems (5G) promises unprecedented levels of connectivity and quality of service (QoS) to satisfy the incessant growth in the number of mobile smart devices and the huge increase in data demand. One of the primary ways 5G network technology will be accomplished is through network densification, namely increasing the number of antennas per site and deploying smaller and smaller cells.
Notes on a Classroom Research Program (1988)

Sometimes, when you least expect it, a good idea stands up, introduces itself, and asks to be recognized. So it happened two years ago at the AAHE meetings. Pat Cross was urging us all to take teaching seriously -- not a particularly novel idea for POD folks -- but we sat up and took notice when she proposed.
Atomic Force Microscopy with Raman and Tip-Enhanced Raman Spectroscopy (2012)

Both atomic force microscopy (AFM) and Raman spectroscopy are techniques used to gather information about the surface properties of a sample. There are many reasons to combine these two technologies, and this article looks both at the complementary information gained from the techniques and how a researcher having access to a combined system can benefit from the additional information available.
Iontophoretic application of idoxuridine for recurrent herpes labialis: report of preliminary clinical trials. (1979)

In clinical trials on six patients the antiviral drug idoxuridine (Stoxil) was applied by anodal (+) iontophoresis to 14 recurrent herpes labialis lesions. Results were characterized by immediate relief of discomfort and swelling, rapid appearance and coalescence of vesicles, minimal or no spread of the lesions, and accelerated healing with minimal or no scab. These encouraging trials indicate that a full-scale, double-blind, controlled clinical study should be carried out to determine whether iontophoresis is the optimal method of applying idoxuridine to the surface lesions caused by herpesvirus.
An active optical detector for high frequency ultrasound imaging (2002)

Optical detection of ultrasound has numerous advantages over traditional piezoelectric methods. These systems offer non-contact inspection, rapid scanning capabilities, fine spatial sampling and large bandwidths. In addition, difficulties associated with conventional ultrasound imaging systems such as cross-talk between elements, electrical connections, and electromechanical resonances are greatly reduced or even eliminated. However, optical systems have lower sensitivity than their piezoelectric counterparts, limiting their widespread use in ultrasound imaging. Active optical detection offers a solution. An active ultrasound detector, consisting of a neodymium-doped glass waveguide laser with an optical demodulation system, was built demonstrating enhanced sensitivity while preserving the benefits of traditional passive optical detection.
Ethnic disparities in the perception of ethical risks from psychiatric genetic studies (2011)

To examine if ethnic differences in concerns about unfavorable consequences from psychiatric genetic studies, existing between non-Hispanic Black and White populations, persist among participants in an actual genetic study of bipolar disorder. Historically, minority subjects have been less willing to participate in such studies. Participants in the US Bipolar Genome Study (BIGS) were assessed on six items of concerns in the Questionnaire on Genetic Risk (QGR). Each item had five response categories, ranging from "not at all" concerned to "very concerned." Responses from Black (N = 188) and White participants (N = 1,065) formed the base for this analysis. Concerns about unfavorable consequences of conducting psychiatric genetic studies were prevalent in the whole sample. Concern for medical insurance was most prevalent (63.4%), followed by job concern (58.8%) and stigma (57.4%). Racial discrimination was less prevalent (28.1%). Blacks endorsed significantly stronger concerns for all consequences except the medical insurance item (P < 0.008). The most significant ethnic disparity in concerns was for racial discrimination (P < 0.0001). Associations between levels of concern and ethnicity remained significant after adjustments for other factors in multivariate models. Ethnic differences (Blacks vs. Whites) in perceived concerns about unfavorable consequences from participation persist among participants in an actual psychiatric genetic study. This suggests that other factors may play a more critical role in the decision not to participate. Future studies should investigate more comprehensive sources of barriers to consenting for ongoing psychiatric genetic studies in representative samples, incorporating assessments from non-participants as well as participants.
Fault restoration using N-fail-safe logic (1972)

A new scheme for fault restoration in logic circuits using N-fail-safe logic is proposed. Its failure probability is shown to be significantly less than those of the majority voting scheme and quadded logic, although the cost of realization is comparable to both.
Adaptive receive-antenna selection technique for Spatial Modulation MIMO systems (2015)

In this paper, we propose an adaptive receive antenna selection technique for Spatial Modulation (SM) MIMO systems. The proposed method is simple and uses channel state information (CSI) available at the receiver to choose the best subset of active receive antennas among the available N <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">r</inf> receive antennas. Simulation results show that SM MIMO system with the proposed receive antenna selection scheme provides a performance gain of approximately 5 dB over conventional SM system (SM MIMO system without antenna selection). The proposed scheme does not increase the RF chain requirement at the receiver and retains all the benefits of SM MIMO.
Emitting-state potential energy surface and distortions calculated from the excitation spectrum of bis(hexafluoroacetylacetonato)platinum(II) in a molecular beam (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEmitting-state potential energy surface and distortions calculated from the excitation spectrum of bis(hexafluoroacetylacetonato)platinum(II) in a molecular beamChristian Reber and Jeffrey I. ZinkCite this: Inorg. Chem. 1992, 31, 13, 2786–2790Publication Date (Print):June 1, 1992Publication History Published online1 May 2002Published inissue 1 June 1992https://pubs.acs.org/doi/10.1021/ic00039a023https://doi.org/10.1021/ic00039a023research-articleACS PublicationsRequest reuse permissionsArticle Views44Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
PERCEPTIONS OF MOBILE ASSISTED E-COOPERATIVE LEARNING QUALITY (2013)

This study was to examine students’ learning experience during collaborative learning tasks in a social e-learning environment with mobile apps, based on social constructivism theory in higher education settings. To better understand the quality of students’ learning experience, 52 university students answered a questionnaire after experiencing a mobile assisted social e-learning system. The survey was designed to measure 7 variables from students’ perspective, positive interdependence, individual accountability, group processing, social skills, face-to-face interaction, quality of feedback, and perceived ability. There were 4 dimensions in evaluating students’ quality of learning experiences, usefulness, confidence, motivation, and satisfaction. The results showed that perceived individual accountability and quality of feedback were found to predict perceived learning quality. Further, the results demonstrated that quality of feedback on the social performance of individual group members can enhance the perceived learning quality. Results revealed that students favored working collaboratively using hand-held devices in a socially connected e-learning environment.
Evaluation of Molecular Markers for Phytophthora ramorum Detection and Identification: Testing for Specificity Using a Standardized Library of Isolates (2009)

Given the importance of Phytophthora ramorum from a regulatory standpoint, it is imperative that molecular markers for pathogen detection are fully tested to evaluate their specificity in detection of the pathogen. In an effort to evaluate 11 reported diagnostic techniques, we assembled a standardized DNA library using accessions from the World Phytophthora Genetic Resource Collection for 315 isolates representing 60 described Phytophthora spp. as well as 11 taxonomically unclassified isolates. These were sent blind to collaborators in seven laboratories to evaluate published diagnostic procedures using conventional (based on internal transcribed spacer [ITS] and cytochrome oxidase gene [cox]1 and 2 spacer regions) and real-time polymerase chain reaction (based on ITS and cox1 and 2 spacer regions as well as beta-tubulin and elicitin genes). Single-strand conformation polymorphism (SSCP) analysis using an automated sequencer for data collection was also evaluated for identification of all species tested. In general, the procedures worked well, with varying levels of specificity observed among the different techniques. With few exceptions, all assays correctly identified all isolates of P. ramorum and low levels of false positives were observed for the mitochondrial cox spacer markers and most of the real-time assays based on nuclear markers (diagnostic specificity between 96.9 and 100%). The highest level of false positives was obtained with the conventional nested ITS procedure; however, this technique is not stand-alone and is used in conjunction with two other assays for diagnostic purposes. The results indicated that using multiple assays improved the accuracy of the results compared with looking at a single assay alone, in particular when the markers represented different genetic loci. The SSCP procedure accurately identified P. ramorum and was helpful in classification of a number of isolates to a species level. With one exception, all procedures accurately identified P. ramorum in blind evaluations of 60 field samples that included examples of plant infection by 11 other Phytophthora spp. The SSCP analysis identified eight of these species, with three identified to a species group.
First-Principles Energy Band Calculation for ZnSb2O6 with Trirutile-Type Structure (2001)

Abstract The electronic structure of ZnSb2O6 is calculated by using the FLAPW method and the DV-Xα method. The valence band with the width of ca. 10.5 eV is roughly classified into the two bands, where O 2p orbitals are dominant and hybridize with Zn 3d and Sb 5s orbitals. On the other hand, the lower conduction band is mainly constructed from Sb 5s orbitals which have large spatial extent. Therefore, ZnSb2O6 crystal is expected to have large electron mobility with doping carriers.
Facial Dynamics in Biometric Identification (2008)

This paper investigates the use of facial gestures for identity recognition. This is the first time that such a quantitative evaluation is conducted, comparing the analyses of 2D versus 3D dynamic data of verbal and nonverbal facial actions. Suitable data processing and feature extraction methods are examined, then a number of pattern matching techniques including the Fr´echet distance, Correlation Coefficients, Hidden-Markov Models, Dynamic TimeWarping and its derived forms are compared, in light of which an improved algorithm is proposed. Finally, a face recognition prototype using facial dynamics is built, achieving an Equal Error Rate EER=1.6%.
53.2: Field‐Sequential‐Color LCD Using Switched Organic EL Backlighting (1999)

Abstract A new field sequential full‐color display composed of an optical compensated birefringent (OCB) LCD and a multicolored organic electro luminescent device (OEL) is proposed. In this display system, each merits of the LC device with high resolution capability and the OEL device with high‐speed response are combined. We fabricated a trial panel and confirmed its promising characteristics as a field sequential full‐color display in the next generation. Furthermore we suggest an advanced driving method. In this system, certain areas of stripe R, G or B phosphors are flashed sequentially by synchronizing with addressing LCD. This system can make the load of TFT decrease and get high intensity.
Evaluation of nonlinearity and complexity in SSTs systems (2012)

This paper addresses the complexity and nonlinear dynamics that may arise in solid state transformers (SST). SST in contrast to the conventional transformer is prone to nonlinear and complex dynamics due to incorporation of power electronic (PE) converter and devices. This is because of nonlinear nature, interdependence and coupling, and feedbacks (e.g. control) of these converters. In this paper, the nonlinear and complex behavior of a SST connected to the power grid will be investigated by presenting some test results in normal or extreme operation of system. Then a methodology of complexity quantification will be proposed, which is a refinement of a popular measure called approximate entropy (ApEn). This methodology will be used to interpret some complex behavior of SST system. The detailed model and control scheme of SST including AC/DC rectifier, Dual Active Bridge (DAB) converter and DC/AC inverter are developed to enable dynamic system level simulation.
Development of a High Affinity, Non-covalent Biologic to Add Functionality to Fabs (2015)

Functionalization of monoclonal antibodies (mAbs) requires chemical derivatization and/or genetic manipulation. Inherent in these methods are challenges with protein heterogeneity, stability and solubility. Such perturbations could potentially be avoided by using a high affinity, non-covalent intermediate to bridge the desired functionality to a stable mAb. Recently, we engineered a binding site for a peptide named "meditope" within the Fab of trastuzumab. Proximity of the meditope site to that of protein L suggested an opportunity to enhance the meditope's moderate affinity. Joined by a peptide linker, the meditope-protein L construct has a KD ~ 180 pM - a 7000-fold increase in affinity. The construct is highly specific to the engineered trastuzumab, as demonstrated by flow cytometry. Moreover, the fusion of a bulky GFP to this construct did not affect the association with cell surface antigens. Collectively, these data indicate this specific, high affinity construct can be developed to rapidly add new functionality to mAbs.