gebhart/patrepeval huggingface dataset:
Low-cost proportional automatic control valve (2020)

El control y la automatizacion son las claves para escalar a la industria 3.0, en un proceso las valvulas de control son responsables de realizar una accion correctiva en el flujo del proceso contra un punto de ajuste en el circuito de control PID, desafortunadamente su alto costo no permite la implementacion de estos equipos en academia y pequenas industrias. Este proyecto se baso en el desarrollo de un prototipo funcional en hardware y software de una valvula proporcional para control automatico de bajo costo, acoplando una valvula convencional encontrada en el mercado configurada con microcontroladores, obteniendo un dispositivo de bajo costo en comparacion con los existentes en el mercado que satisfaga necesidades similares. El proyecto se dividio en cuatro etapas: i) acoplamiento mecanico de la valvula y el motor paso a paso, ii) conexion electrica del motor con el microcontrolador Arduino, iii) programacion del codigo para controlar el porcentaje de apertura de la valvula en relacion directa con el numero de pasos del motor, iv) transcripcion del codigo de programacion al microcontrolador Raspberry para controlar la valvula con el telefono celular. Se realizo un prototipo funcional con capacidad de respuesta rapida y se configuraron cinco botones para el porcentaje de apertura de 0, 25, 50, 75, 100%. Ademas de esto, fue posible construir una interfaz de celda de valvula con un microcontrolador Raspberry ejecutado a traves de la aplicacion movil de Google, Home Assistant, para controlar la valvula de forma remota.
Immunomodulatory function and in vivo properties of Pediococcus pentosaceus OZF, a promising probiotic strain (2012)

Some of the important properties of probiotics are the ability to survive during gastrointestinal transit and to modulate the immune functions. The objectives of the reported study were to assess in vivo gastrointestinal survival of orally administered Pediococcus pentosaceus OZF using an animal model BALB/c mice, and to examine its effects on the immune response. Following oral administration to mice, the ability of Pediococcus pentosaceus OZF to pass and survive through the mouse gastrointestinal system was investigated by analyzing the recovery of the strain in fecal samples. Microbiological and polymerase chain reaction (PCR) methods proved that the strain OZF could overcome specific conditions in the gastrointestinal tract of mice and reach the intestine alive after ingestion. To observe the effect of oral administration on immune response, IL-6, IL-12 and IFN-γ were measured by ELISA, and the strain OZF was found to cause increases in IL-6 synthesis in regularly fed mice. However, stimulation was carried out with various concentrations of bacterial ssDNA and heat killed cells of Pediococcus pentosaceus OZF. The heat killed cells of the strain OZF were shown to produce IFN-γ independently from IL-12. On the other hand, a significant difference between control and experimental group was noticed when lipopolysaccharide, a TLR4 (toll like receptor) ligand, was used. Overall, Pediococcus pentosaceus OZF may be a valuable probiotic strain for therapeutic uses. Nevertheless, further studies on the mechanisms of immunomodulatory effect will allow for better clarification of the immune functions of this strain.
New Particle Formation and Growth in an Isoprene-Dominated Ozark Forest: From Sub-5 nm to CCN-Active Sizes (2014)

Particle Investigations at a Northern Ozarks Tower: NOx, Oxidant, Isoprene Research (PINOT NOIR) were conducted in a Missouri forest dominated by isoprene emissions from May to October 2012. This study presents results of new particle formation (NPF) and the growth of new particles to cloud condensation nuclei (CCN)-active sizes (∼100 nm) observed during this field campaign. The measured sub-5 nm particles were up to ∼20,000 cm-3 during a typical NPF event. Nucleation rates J1 were relatively high (11.0 ± 10.6 cm-3 s-1), and one order of magnitude higher than formation rates of 5 nm particles (J5). Sub-5 nm particle formation events were observed during 64% of measurement days, with a high preference in biogenic volatile organic compounds (BVOCs)- and SO2-poor northwesterly (90%) air masses than in BVOCs-rich southerly air masses (13%). About 80% of sub-5 nm particle events led to the further growth. While high temperatures and high aerosol loadings in the southerly air masses were not favorable for nucleation, high BVOCs in the southerly air masses facilitated the growth of new particles to CCN-active sizes. In overall, 0.4-9.4% of the sub-5 nm particles grew to CCN-active sizes within each single NPF event. During a regional NPF event period that took place consecutively over several days, concentrations of CCN size particles increased by a factor of 4.7 in average. This enhanced production of CCN particles from new particles was commonly observed during all 13 regional NPF events during the campaign period.
Bridging the Gap: From Homogeneous to Heterogeneous Parahydrogen‐induced Hyperpolarization and Beyond (2021)

Demonstration of parahydrogen-induced polarization effects in hydrogenations catalyzed by heterogeneous catalysts instead of metal complexes in a homogeneous solution has opened an entirely new dimension for parahydrogen-based research, demonstrating its applicability not only for the production of catalyst-free hyperpolarized liquids and gases and long-lived non-equilibrium spin states for potential biomedical applications, but also for addressing challenges of modern fundamental and industrial catalysis including advanced mechanistic studies of catalytic reactions and operando NMR and MRI of reactors. This essay summarizes the progress achieved in this field by highlighting the research contributed to it by our colleague and friend Kirill V. Kovtunov whose scientific career ended unexpectedly and tragically at the age of 37. His role in this research was certainly crucial, further enhanced by a vast network of his contacts and collaborations at the national and international level.
The functional evaluation of waste yuzu (Citrus junos) seeds (2013)

We have succeeded in extracting a large amount of expensive limonoids and the high total antioxidant capability yuzu seed oil from waste yuzu seed by simple methods. Yuzu seeds contain higher amounts of fat-soluble limonoid aglycone (330.6 mg g(-1) of dry seed), water-soluble limonoid glycoside (452.0 mg g(-1) of dry seed), and oil (40 mg g(-1) of green seed) than other citrus fruits. The antioxidant activities of yuzu seed aglycone, glycoside, and seed oil were evaluated in vitro. The potential antioxidant activity in oil solution, diphenylpicrylhydrazyl radical-scavenging activity, and hydrogen peroxide-scavenging activity effects of the seed extracts were also investigated. The antioxidant activity of yuzu seed oil was two times that of grapefruit seed oil, which has high activity. Yuzu glycoside produced the same high antioxidant activity as Luo Han Guo glycoside.
A Wideband Dual-Sleeve Monopole Antenna for Indoor Base Station Application (2011)

The design and enhanced bandwidth performance of a dual-sleeve monopole antenna for indoor base station application is presented. By a top-loading circular patch shorted to the ground plane through four shorting probes, the size reduction is achieved. The dual-sleeve structure is successfully employed to improve the impedance bandwidths through achieving another two resonant modes. A measured impedance bandwidth for VSWR ≤ 2 of about 137% ranging from 730 to 3880 MHz is achieved. It is very suitable for GSM900, DCS1800, PCS1900, UMTS, IMT2000, WiBro, WiMAX2350/3500, and wireless LAN (IEEE 802.11b).
Paclitaxel-loaded Folate-targeted Albumin-Alginate Nanoparticles Crosslinked with Ethylenediamine. Synthesis and In Vitro Characterization. (2021)

Among the different ways to reduce the secondary effects of antineoplastic drugs in cancer treatment, the use of nanoparticles has demonstrated good results due to the protection of the drug and the possibility of releasing compounds to a specific therapeutic target. The &amp;alpha;-isoform of folate receptor (FR) is overexpressed on a significant number of human cancers; therefore, folate-targeted crosslinked nanoparticles based on BSA and alginate mixtures and loaded with paclitaxel (PTX) have been prepared to maximizing the proven antineoplastic activity of the drug against solid tumors. Nanometric-range sized particles (169 &amp;plusmn; 28nm - 296 &amp;plusmn; 57nm), with negative Z-potential values (between -0.12 &amp;plusmn; 0.04 and -94.1&amp;plusmn; 0.4), were synthesized. The loaded PTX (2.63&amp;plusmn;0.19 - 3.56 &amp;plusmn;0.13 &amp;micro;g PTX/mg Np) was sustainably released along 23 and 27h. Three cell lines (MCF-7, MDA-MB-231 and HeLa) were selected to test the efficacy of the folate-targeted PTX-loaded BSA/ALG nanocarriers. The presence of FR on cell membrane led to a significant larger uptake of BSA/ALG-Fol nanoparticles regarding to the equivalent nanoparticles without folic acid on its surface. The cell viability results demonstrated a cytocompatibility of unloaded nanoparticle-Fol and a gradual decrease in cell viability after treatment with PTX-loaded nanoparticles-Fol due to the sustainable PTX release.
dc conductivity and the Meyer-Neldel rule ina-Si:H (1988)

Disorder in amorphous semiconductors results in unusual properties of dc conductivity. We demonstrate a quantitative description of the temperature dependence of conductivity in $a$-Si:H. The universal activation energy dependence of the conductivity prefactor (the Meyer-Neldel rule) is reproduced. Excellent agreement with experimental results is obtained by describing disorder and defects using the general thermodynamic ensemble theory for the structure of disordered systems.
Retinal Organoids On-a-Chip: A 3D Printed Micro-Millifluidic Bioreactor for Long-Term Retinal Organoid Maintenance (2021)

&lt;div&gt;Retinal degeneration is a leading cause of vision impairment and blindness worldwide and medical care for advanced disease does not exist. Stem cell-derived retinal organoids (RtOgs) became an emerging tool for tissue replacement therapy. However, existing RtOg production methods are highly heterogeneous. Controlled and predictable methodology and tools are needed to standardize RtOg production and maintenance. In this study, we designed a shear stress-free micro-millifluidic bioreactor. We used a stereolithography (SLA) 3D printer to fabricate a mold from which Polydimethylsiloxane (PDMS) was cast. The multi-chamber bioreactor design and fabrications methods easily combined micro and millimeter features with very low cost and short manufacturing time. We optimized the chip design using in silico simulations and in vitro evaluation to optimize mass transfer efficiency and concentration uniformity in each culture chamber. We successfully cultured RtOgs on an optimized bioreactor chip for 37 days. We also characterized the RtOgs produced by static dish culture and chip culture methods using qualitative and quantitative techniques. Phase contrast imaging showed that both conventional and chip-cultured RtOgs developed a transparent outermost surface structure. Fluorescence lifetime imaging (FLIM) showed that RtOgs on the chip had significantly lower long lifetime species (LLS) ratio than static cultured ones, which demonstrated that bioreactor cultured RtOgs exhibited less oxidative stress. RtOgs in bioreactor culture demonstrated higher NADH signal overall, but both bioreactor and conventional cultures showed similar free/bound NADH ratio over time, which indicated normal differentiation time course. RtOg gene expression was examined by fluorescence imaging and quantitative polymerase chain reaction (qPCR) analyses. RtOgs in both groups showed thick nuclear outer layers expressing CRX on day 120 of differentiation. The gene profiling showed both groups expressed retinal progenitor genes and most of the tested photoreceptor markers. We, therefore, validated an autonomous micro-millifluidic device with significantly reduced shear stress and lower oxidative stress to produce RtOgs of equal or greater quality than those maintained in conventional static culture. &lt;/div&gt;
Resource sharing in a hybrid partitioned/global scheduling framework for multiprocessors (2015)

For resource-constrained embedded real-time systems, resource-efficient approaches are very important. Such an approach is presented in this paper, targeting systems where a critical application is partitioned on a multi-core platform and the remaining capacity on each core is provided to a noncritical application using resource reservation techniques. To exploit the potential parallelism of the non-critical application, global scheduling is used for its constituent tasks. Previously, we enabled intra-application resource sharing for such a framework, i.e. each application has its own dedicated set of resources. In this paper, we enable inter-application resource sharing, in particular between the critical application and the non-critical application. This effectively enables resource sharing in a hybrid partitioned/global scheduling framework on multiprocessors. For resource sharing, we use a spin-based synchronization protocol. We derive blocking bounds and extend existing schedulability analysis for such a system.
High-Yielding Synthesis of Methyl Orthoformate-Protected Hydroxytyrosol and Its Use in Preparation of Hydroxytyrosyl Acetate (2007)

The new methyl orthoformate of the powerful antioxidant hydroxytyrosol (or 2-(3,4-dihydroxyphenyl)ethanol) has been synthesized by a two-step high yielding procedure. The protection stabilizes hydroxytyrosol against fast oxidation and allows both easy chromatographic purification and long term storage. The protective group is hydrolyzed over pH = 10 and below pH = 5, thus allowing the release of the active principle under physiological conditions. The use of the methyl orthoformate-protected hydroxytyrosol allows the preparation of protected hydroxytyrosyl esters, like the acetate herein reported, by selective esterification of the alcoholic function. The subsequent quantitative deprotection under non-aqueous and mild conditions affords the hydroxytyrosyl acetate in high yields.
Association of HIV neutralizing antibody with lower viral load after treatment interruption in a prospective trial (A5170) (2011)

The data suggest that high-titer NAb responses at the time of treatment interruption are associated with reduced viral load over time, but not CD4(+) T-cell decline.
Recurrent urinary tract infection in the post‐transplant reflux nephropathy patient: Is reflux in the native ureter the culprit? (2005)

We assessed the prevalence of symptomatic, refluxing systems as a cause of recurrent urinary tract infection (UTI) in patients who underwent renal transplantation as result of renal failure from reflux nephropathy. Eleven patients from the age of 8 to 19 yr underwent renal transplantation for renal failure because of reflux nephropathy, between 1992 and 2003. Culture documented UTI were investigated and correlated with pre- and postoperative infection rates, voiding dysfunction (VD), concomitant nephrectomy, or nephroureterectomy with refluxing native remnants, and pretransplant ureteral reimplantation. Four patients with nephroureterectomies and no VD were infection free post-transplant. Two of three patients reimplanted pretransplant with a history of VD had one or more UTI per month. Patients with nephrectomies without partial ureterectomies with or without VD also had one or more UTI per month. Refluxing systems in the immunosuppressed transplant patient may play a role in UTI especially when associated with VD. Surgical intervention of native refluxing systems may be warranted.
Violaxanthin Cycle Pigment Contents in Potato and Tobacco Plants with Genetically Reduced Photosynthetic Capacity (1995)

The influence of photosynthetic activity on the light-dependent adaptation of the pool size of the violaxanthin cycle pigments (violaxanthin + antheraxanthin + zeaxanthin) was studied in leaves of wild-type and transgenic potato (Solanum tuberosum L.) and tobacco (Nicotiana tabacum L.) plants. The genetically manipulated plants expressed an antisense mRNA coding for the chloroplastic fructose-bisphosphatase. Chl fluorescence quenching analysis revealed that the transformed plants exhibited a greatly impaired electron transport capacity. Light-limited and light-saturated non-photochemical quenching was strongly enhanced in the mRNA antisense potato plants. After 7 d of adaptation at various high photosynthetic photon flux densities (PPFDs), the violaxanthin cycle pool size increased, with a progressive elevation in PPFD. The pool size was higher for transgenic potatoes than for wild-type plants at all PPFDs. This difference vanished when pool size was correlated with the PPFD in excess of photosynthesis, as indicated by the epoxidation state of the violaxanthin cycle. Contrasting results were obtained for tobacco; in this species, photosynthetic activity did not affect the pool size. We conclude that regulatory mechanisms exist in potato, by which photosynthetic activity can influence the violaxanthin cycle pool size. Furthermore, evidence is provided that this adaptation of the pool size may contribute to an improved photoprotection of the photosynthetic apparatus under high-light conditions. However, tobacco plants seem to regulate their pool size independently of photosynthetic activity.
Effects of pulse polarity on temporal interactions: Detection thresholds and loudness growth functions (2014)

International audience
Production of l-alanyl-l-glutamine by immobilized Pichia pastoris GS115 expressing α-amino acid ester acyltransferase (2019)

Characterized by economy, efficiency and practicability, production of Ala-Gln by recycling immobilized GPAp (whole-cell biocatalyst) is represents a green and promising way in industrial.
Involvement of androgen receptor in nitric oxide production induced by icariin in human umbilical vein endothelial cells (2010)

Icariin, a flavonoid isolated from Epimedii herba, stimulated phosphorylation of endothelial nitric oxide synthase (eNOS) at Ser1177, Akt (Ser473) and ERK1/2 (Thr202/Tyr204). The icariin-induced eNOS phosphorylation was abolished by an androgen receptor (AR) antagonist, nilutamide in human umbilical vein endothelial cells (HUVECs). Furthermore, it was also reduced in the cells transfected with small interfering RNA in which the expression of AR was broken down. The icariin-induced eNOS phosphorylation was inhibited by wortmannin, a phosphatidylinositol 3-kinase (PI3K) inhibitor and partially attenuated by PD98059, an upstream inhibitor for ERK1/2. These data suggest that icariin stimulates release of NO by AR-dependent activation of eNOS in HUVECs. PI3K/Akt and MAPK-ERK kinase (MEK)/ERK1/2 pathways were involved in the phosphorylation of eNOS by icariin.
Targeted Protein Degradation by Salmonella under Phagosome-mimicking Culture Conditions Investigated Using Comparative Peptidomics (2007)

The pathogen Salmonella enterica is known to cause both food poisoning and typhoid fever. Because of the emergence of antibiotic-resistant isolates and the threat of bioterrorism (e.g. contamination of the food supply), there is a growing need to study this bacterium. In this investigation, comparative peptidomics was used to study S. enterica serovar Typhimurium cultured in either a rich medium or in an acidic, low magnesium, and minimal nutrient medium designed to roughly mimic the macrophage phagosomal environment (within which Salmonella are known to survive). Native peptides from cleared cell lysates were enriched by using isopropanol extraction and analyzed by using both LC-MS/MS and LC-FTICR-MS. We identified and quantified 5,163 peptides originating from 682 proteins, and the data clearly indicated that compared with Salmonella cultured in the rich medium, cells cultured in the phagosome-mimicking medium had dramatically higher abundances of a wide variety of protein degradation products, especially from ribosomal proteins. Salmonella from the same cultures were also analyzed using traditional, bottom-up proteomic methods, and when the peptidomics and proteomics data were analyzed together, two clusters of proteins targeted for proteolysis were tentatively identified. Possible roles of targeted proteolysis by phagocytosed Salmonella are discussed.
Effects of enamel anisotropy on stress singularities in restorations of premolar class II cavities (2008)

This paper studies the strength of inplane and antiplane stress singularities near the apex of a structure formed from the dental restoration of premolar class II cavity. In order to exclude the probability of failure, it is necessary to find the conditions such that singularity orders are kept to a minimum or inplane and antiplane stress fields are non‐singular.The effects of enamel anisotropy on the stress singularities are emphasized at two critical positions in the restoration structure: (1) the apex of the enamel and restoration interface, and (2) the apex of the enamel, dentine and restoration junction. In the second case, the interface between the restoration and enamel may be bonded or debonded. The results of this paper show that the recommended cutting angles are strongly affected by the ratio R of transverse stiffness to the longitudinal stiffness. Besides, if the stiffness of the restoration material is close to the transverse stiffness of the enamel, the singularity orders will be reduced. The results of previous studies, in which the enamel is considered to be isotropic, should be modified.
Nanoscale Au-ZnO Heterostructure Developed by Atomic Layer Deposition Towards Amperometric H2O2 Detection (2020)

Nanoscale Au-ZnO heterostructures were fabricated on 4-in. SiO<sub>2</sub>/Si wafers by the atomic layer deposition (ALD) technique. Developed Au-ZnO heterostructures after post-deposition annealing at 250 °C were tested for amperometric hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) detection. The surface morphology and nanostructure of Au-ZnO heterostructures were examined by field emission scanning electron microscopy (FE-SEM), Raman spectroscopy, atomic force microscopy (AFM), X-ray photoelectron spectroscopy (XPS), etc. Additionally, the electrochemical behavior of Au-ZnO heterostructures towards H<sub>2</sub>O<sub>2</sub> sensing under various conditions is assessed by chronoamperometry and electrochemical impedance spectroscopy (EIS). The results showed that ALD-fabricated Au-ZnO heterostructures exhibited one of the highest sensitivities of 0.53 μA μM<sup>-1</sup> cm<sup>-2</sup>, the widest linear H<sub>2</sub>O<sub>2</sub> detection range of 1.0 μM-120 mM, a low limit of detection (LOD) of 0.78 μM, excellent selectivity under the normal operation conditions, and great long-term stability. Utilization of the ALD deposition method opens up a unique opportunity for the improvement of the various capabilities of the devices based on Au-ZnO heterostructures for amperometric detection of different chemicals.
Draft Genome Sequences of 11 Lactobacillus jensenii Strains Isolated from the Female Bladder (2019)

<i>Lactobacillus jensenii</i>, a protective bacterium in the vaginal microbiota, is also a member of the female urinary tract community. Here, we report 11 genome sequences of <i>L. jensenii</i> strains isolated from catheterized urine from women. This effort greatly increases our knowledge of the genetic diversity of this species within the bladder.