gebhart/patrepeval huggingface dataset:
Vision therapy as part of neurorehabilitation after acquired brain injury – a clinical study in an outpatient setting (2020)

<b>Introduction</b>: Oculomotor (OM) functions may be affected by acquired brain injury (ABI). The ability to benefit from rehabilitation or to perform daily activities may be affected by OM dysfunctions and associated symptoms. The purpose of this study was to investigate the effects of vision therapy (VT) as part of neurorehabilitation after ABI.<b>Materials and Methods</b>: The study included two groups of outpatients (median 49.5-52.0 years, range 27-67) admitted to neurorehabilitation due to moderate to severe ABI. One group received VT while the other group served as controls to monitor the course of OM dysfunctions without VT.<b>Results</b>: The intervention group showed significant improvements in convergence (Z = 2.26, <i>p</i> = .02), vergence facility (Z = -2.16, <i>p</i> = .03) and vergence reserves (Z = -2.44, <i>p</i> < .01 and t = -4.47, DF = 15, <i>p</i> < .01) along with a significant reduction in vision-related symptoms (Z = 2.97, <i>p</i> < .01).<b>Discussion</b>: We conclude that OM issues were frequent and that targeted VT, as part of neurorehabilitation, can be an efficient treatment resulting in improved functions and reduced symptoms. Further study will be required to understand how improved functions link to performance and satisfaction with everyday activities.
Development of high stability fuel. Final report, 1 Jul-31 Dec 1974 on phase I (1975)

Two series of phosphors, Na(0.5)Gd(0.5)WO(4): RE(3+) and Na(0.5)Gd(0.5)(Mo(0.75)W(0.25))O(4): RE(3+) (RE = Eu, Sm, Dy) have been synthesized by hydrothermal process to obtain the high purity, which have been characterized by X-ray powder diffraction (XRD), scanning electron microscope (SEM). The results suggest that Na(0.5)Gd(0.5)(Mo(0.75)W(0.25))O(4): RE(3+) phosphors are more easily to crystallize than Na(0.5)Gd(0.5)WO(4): RE(3+) ones. Both of them present the characteristic luminescence of Eu(3+), Sm(3+) and Dy(3+). Especially the photoluminescent properties of Na(0.5)Gd(0.5)WO(4): x%Eu(3+) (Sm(3+)) can be obtained to show white luminescence as the suitable doping concentration of Eu(3+) or Sm(3+).
Routes to N-glycinamide oxazolidinone derivatives: The reaction of 4-trityloxymethyl-3-oxa-1-azabicyclo[3.1.0]hexan-2-one with active halides (2019)

N-Glycinamide oxazolidinones are key intermediates for the synthesis of a new class of peptidomimetics. We report, herein, the synthesis of a series of 3,4,5-trisubstituted oxazolidinones with a glycine residue at N-3 of the oxazolidinone ring. Substituents at C-4 and C-5 contain substitution capabilities which are amenable for the introduction of additional peptide chains. The synthesis of the key N-Glycinamide oxazolidinone is made possible through two reactions; a tandem aziridine ring opening/oxazolidinone alkylation and, subsequently, a fused-lactone ring opening by an amine which leads to the N-Glycinamide oxazolidinones.
10.1016/s0197-2510(11)70261-3 (2000)

Just as clinical care has requirements for documentation, so does research. Having a contract or memorandum of understanding with research partners outside your organization can establish responsibilities and expectations of all parties, and can provide the groundwork for a solid partnership. Keeping a regulatory binder with all required forms, such as protocol versions, consents, IRB approvals, contracts and signature pages, will keep the study organized.

Before beginning a trial, determine how study data will be recorded. For multicenter studies, there are often prepared case-report forms to be completed. If there aren’t any prepared forms, then create one to ensure that all data is collected and documented (time, date and recorder). Follow regulations regarding how long study documents must be maintained after the study is completed. These regulations may vary depending on the type of study, so be sure to determine this before discarding any documents.

As you can see, you have many things to consider when getting involved in research. If this is your agency’s first attempt at getting involved in research, it may be beneficial for you to partner with an EMS agency that has experience with conducting research, a product manufacturer interested in testing a product or an academic institution. A seasoned investigator can guide you through what may seem like a complicated process. Eventually, as your agency gains experience, you’ll be able to take on greater responsibility in the research process.
Surgical decompression of the peroneal nerve in the correction of lower limb deformities: A cadaveric study (2016)

Background: The peroneal nerve is often stretched during limb lengthening and deformity correction. If the nerve becomes entrapped under the peroneal muscle fascia and/or anterior intermuscular septum, decompression is indicated to treat nerve compromise. Purpose: The purpose of this study was to quantify peroneal nerve tension after varus osteotomy of the proximal tibia and before and after nerve decompression. Methods: A device, which consisted of a force transducer connected perpendicularly by a hook to the nerve and integrated to a personal computer, was able to indirectly measure the nerve rigidity in 14 lower limbs (seven cadaveric specimens). The nerve was neither cut nor disrupted from its anatomic tract by the rigidity measuring device. We measured the amount of peroneal nerve rigidity before varus angulation, after varus angulation of a proximal tibial osteotomy, and after peroneal nerve decompression in the varus angulation position. Results: Peroneal nerve rigidity increased significantly after limb was angulated into varus (P = 0.0002) and was reduced significantly after decompression (P = 0.0003). No significant difference was noted between measurements obtained before varus angulation and measurements obtained after nerve decompression (P = 0.3664). Conclusions: Varus osteotomy of the proximal tibia significantly increases peroneal nerve rigidity. Peroneal nerve rigidity after decompression is not significantly different from nerve rigidity before varus correction. Clinical Relevance: This study provides biomechanical evidence of the efficacy of nerve decompression in two specific anatomic sites (peroneus longus muscle fascia and lateral, intermuscular septum) in relieving the increase in peroneal nerve rigidity that occurs in association with procedures that stretch the nerve such as limb lengthening and deformity correction.
Kapitel 3: Typische Teilhabemuster: Verschiedenheit und Ungleichheit (2017)

Die gesellschaftlichen Möglichkeitsräume werden von Individuen unterschiedlich genutzt, weil sie unterschiedliche Präferenzen haben oder ihnen Teilhabemöglichkeiten versperrt sind. Der Verbund untersucht individuelle Teilhabeergebnisse auf drei verschiedenen Dimensionen: materielle Teilhabe (Einkommen, Vermögen, Konsum), Erwerbsbeteiligung und Teilhabe an sozialen Nahbeziehungen. Das Kapitel fasst die Verbundergebnisse unter folgenden Fragen zusammen: Welche Wohlfahrtseffekte sind für welche Personengruppen zu beobachten? Inwiefern zeigen sich hier Ungleichheiten beim Zugang zu den gesellschaftlich zu verteilenden Ressourcen? Inwiefern sind verschiedenartige Teilhabemuster zu beobachten, die Ausdruck von unterschiedlichen Präferenzen, Lebensweisen sowie sozialer Ausdifferenzierung sind.
Hydrocarbon adsorption on rhodium: a search for reactive intermediates (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHydrocarbon adsorption on rhodium: a search for reactive intermediatesJeffrey M. Cogen and Wilhelm F. MaierCite this: Langmuir 1987, 3, 5, 830–836Publication Date (Print):September 1, 1987Publication History Published online1 May 2002Published inissue 1 September 1987https://pubs.acs.org/doi/10.1021/la00077a044https://doi.org/10.1021/la00077a044research-articleACS PublicationsRequest reuse permissionsArticle Views59Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Investigation of an efficient model-based fuel economy optimization methodology for diesel engines focusing on real world driving emission cycles (2022)

Together with stringent emission standards, meeting fuel consumption, and performance targets have made engine calibration process complicated, lengthy, and costly. For this reason, it is crucial to develop an efficient methodology for the optimization of a diesel engine calibration. In this study, a novel automated fine tuning methodology using genetic algorithms and data driven models is proposed. Fuel consumption of a light commercial vehicle with 2.0-L diesel engine was optimized for a predefined Real Driving Emissions (RDE) cycle. During the optimization, tail pipe emission limits were maintained by taking the aftertreatment system efficiency into account. To this end, a representative engine control unit, internal combustion engine, and Selective Catalyst Reduction (SCR) system models were built by using empirical data and neural networks. Moreover, the effect of choosing different tailored optimization points for a predefined route was investigated by comparison of frequency and fuel consumption based weighting. The cost function, related to the optimization problem, was defined based on fuel consumption, performance, and mechanical limits of the engine, and in accordance with tailpipe emission limits defined by Euro 6d-Temp regulations. Compared to previous model-based calibration studies, tailpipe emissions, and regulation limits have been incorporated in this study in order to obtain more realistic calibrations. After testing different genetic algorithm configurations, the fuel efficiency over the predefined route was improved by 3.07% without violating any of the limits while the smoothness of the calibration maps was also preserved. This route specific calibration methodology is believed to have the potential to increase fuel economy in real world applications such as daily commuting routes or repetitive driving patterns for instance, operation vehicle use cases in factories, airports, and construction areas. As for further development, this can be achieved by running simulations and the optimization on cloud and updating the calibration remotely based on the selected route before the trip.
Explorando o componente inflamatório da esquizofrenia (2012)

A esquizofrenia é uma doença heterogênea caracterizada por um conjunto de manifestações clínicas. Um grande número de estudos ao longo dos últimos 20 anos apontou para anormalidades no sistema imune em pacientes que sofrem dessa condição. Em adição, tem sido mostrado que a psicose e a disfunção cognitiva associadas com a esquizofrenia estão ligadas a doenças autoimunes. Aqui, revisamos a evidência que sugere que um status pró-inflamatório do sistema imune induz sintomas psicopatológicos e pode estar envolvido na fisiopatologia dessa principal doença mental. Também propomos que futuros estudos pré-clínicos e clínicos deveriam levar em conta tais causas predefinidas e o status do componente inflamatório. Estratificação de pacientes e estratégias de medicina personalizadas baseadas no direcionamento ao componente inflamatório da doença poderiam ajudar na redução de sintomas e da progressão da doença. Por fim, isso poderia levar a novos conceitos na identificação de alvos moleculares em esquizofrenia e estratégias de descoberta de drogas.
Optical Deformation Chamber using Digital Image Correlation. (2011)

Abstract not provided.
Same-Day Pegfilgrastim and Chemotherapy (2005)

Pegylated filgrastim is a new formulation of a neutrophil colony-stimulating factor that has a long circulating half-life, permitting a single dose of filgrastim per cycle of chemotherapy. The pegylated filgrastim is recommended to be administered not less than 24 hours following chemotherapy and not less than 14 days prior to chemotherapy based on the theoretic concern that marrow suppression would be accentuated. This schedule of usage for pegylated filgrastim may compromise its application for weekly chemotherapy schedules. We have treated 80 patients with pegylated filgrastim administered on the same day as chemotherapy; the latter delivered on a weekly schedule. Twenty-four patients had non-small cell lung cancer (NSCLC) and were treated with one of two weekly chemotherapy regimens alternating triplets [AT] taxane, cisplatin, irinotecan alternating with gemcitabine, cisplatin, vinorelbine or alternating doublets [AD] taxane, cisplatin alternating with gemcitabine, vinorelbine; four of these patients also received weekly taxane and carboplatin with concomitant thoracic radiation. A consistent pattern emerged in which leukocytosis was observed at Day 8; median WBC 15,800/uL (range 7,200 to 35,000/uL); at Day 14, the median WBC was 9,300/uL (range 1,100 to 17,400/uL). Pegylated filgrastim can be given safely simultaneously with chemotherapy in weekly chemotherapy schedules. The pegfilgrastim can be administered on an every two week (fortnightly) schedule to maintain a weekly chemotherapy schedule.
Vascular endothelial growth factor-D induces lymphangiogenesis and lymphatic metastasis in models of ductal pancreatic cancer. (2005)

The presence of lymphatic metastases is a strong indicator for poor prognosis in patients with ductal pancreatic cancer. In order to better understand the mechanisms controlling lymphatic growth and lymph node metastasis in human ductal pancreatic cancer, we analyzed the expression pattern of the vascular endothelial growth factor-D (VEGF-D), its receptor VEGF-receptor-3 (VEGFR-3) and the lymphatic endothelium-specific hyaluronan receptor LYVE-1 in a panel of 19 primary human ductal pancreatic tumors and 10 normal pancreas specimens. We further addressed the biological function of VEGF-D for induction of lymphatic metastasis in a nude mouse xenograft model using two human ductal pancreatic cancer cell lines with overexpression of VEGF-D. Compared to normal human pancreas, pancreatic cancer tissue showed overexpression of VEGF-D and VEGFR-3 in conjunction with a high lymphatic vascularization as determined by immunohistochemistry and in situ hybridization. Tumors derived from VEGF-D-overexpressing cells had a higher microvessel density compared to their mock-controls, as determined based on CD31 immunohistochemistry. Importantly, these tumors also revealed a significant induction of intra- and peritumoral lymphatics, as judged from immunohistochemical detection of LYVE-1 expression. This was associated with a significant increase in lymphatic vessel invasion by tumor cells and an increased rate of lymphatic metastases, as indicated by pan-cytokeratin reactive cells in lymph nodes. Our results suggest that VEGF-D plays a pivotal role in stimulating lymphangiogenesis and lymphatic metastasis in human ductal pancreatic cancer, and therefore represents a novel therapeutic target for this devastating disease.
Hepatobiliary Cancers: Progress in Diagnosis, Pathogenesis, and Treatment (2022)

Hepatobiliary cancers comprise a wide range of malignancies such as hepatocellular carcinoma and cholangiocarcinoma, and they are some of the most challenging to treat human neoplasms. Due to the rarity of the illnesses, the development of treatment measures for malignancies of the gastrointestinal system is far behind. The number of patients eligible for curative treatment is limited due to cancer's aggressive nature and the difficulties of early identification. Furthermore, surgery is frequently intrusive and linked with a significant level of risk. The therapy result of hepatobiliary cancers is unsatisfactory due to these complicated variables, leaving significant space for improvement.
Exploratory Training: When Annotators Learn About Data (2023)

Data systems often present examples and solicit labels from users to learn a target model, i.e., active learning. However, due to the complexity of the underlying data, users may not initially have a perfect understanding of the effective model and do not know the accurate labeling. For example, a user who is training a model for detecting noisy or abnormal values may not perfectly know the properties of typical and clean values in the data. Users may improve their knowledge about the data and target model as they observe examples during training. As users gradually learn about the data and model, they may revise their labeling strategies. Current systems assume that users always provide correct labeling with potentially a fixed and small chance of annotation mistakes. Nonetheless, if the trainer revises its belief during training, such mistakes become significant and non-stationarity. Hence, current systems consume incorrect labels and may learn inaccurate models. In this paper, we build theoretical underpinnings and design algorithms to develop systems that collaborate with users to learn the target model accurately and efficiently. At the core of our proposal, a game-theoretic framework models the joint learning of user and system to reach a desirable eventual stable state, where both user and system share the same belief about the target model. We extensively evaluate our system using user studies over various real-world datasets and show that our algorithms lead to accurate results with a smaller number of interactions compared to existing methods.
Cell survival and protein secretion associated with Golgi integrity in response to Golgi stress‐inducing agents (2017)

The Golgi apparatus is part of the secretory pathway and of central importance for modification, transport and sorting of proteins and lipids. ADP-ribosylation factors, whose activation can be blocked by brefeldin A (BFA), play a major role in functioning of the Golgi network and regulation of membrane traffic and are also involved in proliferation and migration of cancer cells. Due to high cytotoxicity and poor bioavailability, BFA has not passed the preclinical stage of drug development. Recently, AMF-26 and golgicide A have been described as novel inhibitors of the Golgi system with antitumor or bactericidal properties. We provide here further evidence that AMF-26 closely mirrors the mode of action of BFA but is less potent. Using several human cancer cell lines, we studied the effects of AMF-26, BFA and golgicide A on cell homeostasis including Golgi structure, endoplasmic reticulum (ER) stress markers, secretion and viability, and found overall a significant correlation between these parameters. Furthermore, modulation of ADP-ribosylation factor expression has a profound impact on Golgi organization and survival in response to Golgi stress inducers.
Krylov projection methods for model reduction (1997)

This dissertation focuses on efficiently forming reduced-order models for large, linear dynamic systems. Projections onto unions of Krylov subspaces lead to a class of reducedorder models known as rational interpolants. The cornerstone of this dissertation is a collection of theory relating Krylov projection to rational interpolation. Based on this theoretical framework, three algorithms for model reduction are proposed. The first algorithm, dual rational Arnoldi, is a numerically reliable approach involving orthogonal projection matrices. The second, rational Lanczos, is an efficient generalization of existing Lanczos-based methods. The third, rational power Krylov, avoids orthogonalization and is suited for parallel or approximate computations. The performance of the three algorithms is compared via a combination of theory and examples. Independent of the precise algorithm, a host of supporting tools are also developed to form a complete model-reduction package. Techniques for choosing the matching frequencies, estimating the modeling error, insuring the model&amp;apos;s stability, treating multiple-input multiple-output systems, implementing parallelism, and avoiding a need for exact factors of large matrix pencils are all examined to various degrees.
Insulin, carbohydrate restriction, metabolic syndrome and cancer (2014)

We propose that dietary carbohydrate restriction, particularly ketogenic diets, may provide benefit as a therapeutic or preventive strategy in cancer, alone or as an adjunct to pharmacology. The argument derives from several points of evidence: There is a close association between cancer and both diabetes and obesity. Extensive evidence shows that low carbohydrate diets are the most effective dietary treatment of Type 2 diabetes and dietary adjunct in Type 1. Such diets also target all the markers of metabolic syndrome. Finally, de facto reduction in carbohydrate likely contributes to total dietary restriction, which is effective in the prevention and treatment of cancer. The idea is consistent with recent interest in treating cancer with drugs that target diabetes. To move forward, we must understand obesity and diabetes as response to a hyperglycemic state rather than simply a cause of downstream effects.
Cephalosporin-resistant Shigella flexneri over 9 years (2001-09) in India (2012)

We report a high level of cephalosporin resistance with high MICs and ESBL- and AmpC-mediated antibiotic resistance in Shigella from north India.
First Detection of P[6],G9 Rotaviruses in Hungary—An Imported Strain From India? (2009)

EuroRotaNet was launched to monitor rotavirus strain prevalence during and after introduction of rotavirus vaccines in Europe. In early 2007, we detected P[6],G9 rotaviruses to appear in Hungary, representing the first documented occurrence of this strain in our surveillance area. Epidemiologic data suggested that this strain was introduced from India.
De novo transcriptome sequencing in Bixa orellana to identify genes involved in methylerythritol phosphate, carotenoid and bixin biosynthesis (2015)

The identification and qRT-PCR quantification of cDNAs involved in annatto production suggest a hypothetical model for bixin biosynthesis that involve coordinated activation of some MEP, carotenoid and bixin pathway genes. These findings provide a better understanding of the mechanisms regulating these pathways and will facilitate the genetic improvement of B. orellana.
GROWTH DIFFERENTIATION FACTOR-15 DECREASES TUMORIGENESIS AND INVASION IN PC-3 PROSTATE CARCINOMA CELLS (2008)

You have accessJournal of Urology1 Apr 2008GROWTH DIFFERENTIATION FACTOR-15 DECREASES TUMORIGENESIS AND INVASION IN PC-3 PROSTATE CARCINOMA CELLS Horng-Heng Juang and Ke-Hung Tsui Horng-Heng JuangHorng-Heng Juang More articles by this author and Ke-Hung TsuiKe-Hung Tsui More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(08)60131-7AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "GROWTH DIFFERENTIATION FACTOR-15 DECREASES TUMORIGENESIS AND INVASION IN PC-3 PROSTATE CARCINOMA CELLS." The Journal of Urology, 179(4S), pp. 43–44 © 2008 by American Urological AssociationFiguresReferencesRelatedDetails Volume 179Issue 4SApril 2008Page: 43-44 Advertisement Copyright & Permissions© 2008 by American Urological AssociationMetricsAuthor Information Horng-Heng Juang More articles by this author Ke-Hung Tsui More articles by this author Expand All Advertisement PDF downloadLoading ...