gebhart/patrepeval huggingface dataset:
A randomized clinical trial evaluating the efficacy and safety of the addition of oral metronomic chemotherapy after completion of standard chemoradiation versus observation in patients with locally advanced esophageal and gastroesophageal junction squamous cell carcinoma. (2021)

163 Background: In RTOG 85-01, patients with locally advanced esophageal and gastroesophageal junction (GEJ) cancer treated with concurrent chemoradiotherapy (CRT) had a median overall survival (OS) of 14 months and 5-year OS of 27%. Improving outcomes in these patients is an unmet need. We investigated the addition of oral metronomic chemotherapy (OMC) following definitive CRT. Methods: A randomized integrated phase II/III clinical trial (CTRI/2015/09/006204) in patients with squamous cell carcinoma of the esophagus or the GEJ who had completed definitive radical CRT within the past 12 weeks, had an ECOG PS 0-2 and no clinical or radiologic evidence of progressive disease. Patients were stratified based on whether or not they had received induction chemotherapy followed by CRT, and then randomized 1:1 to receive OMC (celecoxib 200 mg twice daily and methotrexate 15 mg/m 2 weekly) for 12 months or observation. The primary efficacy endpoint for the phase II portion was progression free survival (PFS). The secondary endpoints were OS and toxicity. With a power of 70% and an alpha of 10%, we hypothesized a hazard ratio of 1.5, with a median follow-up of 6 months. The planned sample size for the phase II portion was 151 patients. The p-value for stopping the trial after the phase II part of the study was set at 0.2 for the PFS. Results: Between Jan 2016 and Dec 2019, we enrolled 151 patients, 75 to the OMC arm and 76 to observation. The median age was 57 years, 59% were male. The tumor originated in the upper thoracic esophagus in 79% patients, with median tumor length 6 cm. Induction chemotherapy was received by 14% of the patients. Concurrent CRT consisted of median 63 Gy in median 35 fractions; 91% patients received concurrent weekly paclitaxel and carboplatin with radiation. OMC was started at a median of 11 weeks (IQR, 9 to 12) from the start of CRT. Grade 3 or higher toxicities (regardless of relatedness to study intervention) were noted in 27 patients (17.9%), 18 in the OMC arm and 9 in the observation arm; P=0.071. The median time to disease progression or death was 23 months (95% CI, 7.9-38.1) in the OMC arm and not reached in the observation arm; HR, 1.33, 95% CI, 0.83-2.14; P=0.23. The 1-year PFS was 67% in both the arms; the 2-year PFS were 48% and 61% in the OMC and observation arms respectively. The median OS was 36 months (95% CI, 17.9-54) in the OMC arm and not reached in the observation arm; HR, 1.75; 95% CI, 1.02-2.99; P, 0.037. The 1-year OS was 74.7% in the OMC arm and 88% in the observation arm; the 2-year OS was 53.9% in the OMC arm and 75% in the observation arm. Conclusion: Adjuvant oral metronomic chemotherapy after radical CRT does not improve outcomes in patients with locally advanced esophageal or GEJ squamous cell carcinoma. Clinical trial information: CTRI/2015/09/006204.
Effect of Al Addition on Phase Constitution and Heat Treatment Behavior in Ti-8.5mass%Mn-1mass%Fe-Al Alloys (2014)

Titanium is considered to be a ubiquitous element since it has the 9th-highest Clarke number of all elements. Iron and manganese can also be used as beta stabilizers for Ti alloys, and can be considered to be ubiquitous because of their 4th- and 11th-highest Clarke numbers, respectively. However, investigations into the behavior of Ti-Mn-Fe alloys during heat treatment have shown that in some alloys, the isothermal omega phase is precipitated. Because this phase can lead to brittleness, it is very important to prevent it from forming. It is well known that aluminum can suppress the precipitation of the isothermal omega phase. Thus, in the present study, we investigated the effect of Al content on the phase constitution and heat-treatment behavior of Ti-8.5mass%Mn-1mass%Fe-0 to 4.5mass%Al alloys using electrical resistivity, Vickers hardness, and X-ray diffraction measurements. In all solution-treated and quenched alloys, only the beta phase was identified, thus confirming the suppression of omega-phase precipitation. The resistivity was found to increase monotonically with Al content, while the Vickers hardness decreased up to 3 mass% Al and then remained constant.
A gravitational epoch function (1998)

We argue that there is no scalar field P, constructed from the Riemann tensor and its covariant derivatives, which reflects the Weyl curvature and is monotone increasing along almost all timelike trajectories for non conformally flat space-times. That is, no gravitational epoch function P, which measures anisotropy, can be constructed purely from the metric, its inverse and partial derivatives to arbitrary order. In contrast, if P is observer dependent, in the sense that it is constructed from the Riemann tensor and the observer's 4-velocity, then an integral over the superenergy density, derived from the Weyl Bel-Robinson tensor, provides a concrete example of a gravitational epoch function. With the view that the gravitational "entropy" is the rate of change of the epoch function, the Weyl curvature hypothesis can be interpreted as the restriction that in any admissible region of space-time there must exist at least one timelike trajectory along which the gravitational counterpart to the second law of classical thermodynamics holds.
Ambiphilic phosphine-boranes : from the bridging coordination of metal fragments to the stabilisation of reactive intermediates (2008)

International audience
A high performance power line spread-spectrum modem LSI for home bus system (1989)

Among some home bus transmission media, power distribution lines have been investigated as a simple and low-cost data transmission medium, since they provide reasonably universal channels to all residences. The authors have already developed a power line spread-spectrum (SS) modem LSI chip, also introduced a total home bus system based on the main bus and SS power line bus. A home control system based on a Japanese standard SS power line bus is now available in Japan. This paper introduces a high-performance power line SS modem LSI that uses a newly developed SS modulation and SS demodulation technique (CSK: code shift keying). The performance evaluation results indicate that synchronization time is greatly reduced and highly reliable transmission is realized.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Plate Cartridge Compact Flexible Automatic Feed System (2016)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;The newest generation of automated fastening machines require a feed system that is smaller, more flexible, and faster than any currently available. The feed system must be compact enough to fit on a robot base, yet have a capacity large enough to support unmanned production for hours. A large variety of fasteners must be supported and the entire system must be reloaded or reconfigured in minutes to match the next work piece being assembled by the machine. When requested by the part program, the correct fastener must be released directly and immediately into the feed tube to minimize cycle time. This paper describes a new “plate cartridge” feed system developed to meet these needs.&lt;/div&gt;&lt;/div&gt;
Programmable elution profile coating for drug eluting stents. (2005)

Despite good results in reducing in-stent restenosis during cardiac stenting procedures, a number of issues in the application of drug-eluting stents still challenge the industry. These include drug-elution kinetics and long-term biocompatibility. Some of the latest developments in these areas are described here.
Functional discrimination between interleukin 6 and interleukin 1 (1988)

Abstract In this study we have investigated the specificity of bioassays in which interleukin (IL)1 and/or IL6 are active. The thymocyte assay cannot be used to discriminate between IL1 and IL6; both monokines are active in this assay. Moreover the detection limit for both IL1 and IL6 is around 100 pg/ml. IL6 activity can be measured with a murine hybridoma cell line (B9). The detection limit for human as well as murine IL6 is about 0.5 pg/ml. The assay is specific for IL 6 and is not influenced by a variety of other cytokines except for murine IL4 which shows some activity in this assay. IL1 can be measured specifically with D10 cells. The detection limit for IL1α and IL1β is around 1 pg/ml whereas IL6 is not active in this assay at all. Upon stimulation by IL1 and/or IL2 D10 cells produce IL6. However, this IL6 does not seem to be involved in the proliferation of these cells.
Investigating Cortical Inhibition in First-Degree Relatives and Probands in Schizophrenia (2017)

Deficits in GABAergic inhibitory neurotransmission are a reliable finding in schizophrenia (SCZ) patients. Previous studies have reported that unaffected first-degree relatives of patients with SCZ demonstrate neurophysiological abnormalities that are intermediate between probands and healthy controls. In this study, first-degree relatives of patients with SCZ and their related probands were investigated to assess frontal cortical inhibition. Long-interval cortical inhibition (LICI) was measured from the dorsolateral prefrontal cortex (DLPFC) using combined transcranial magnetic stimulation (TMS) and electroencephalography (EEG). The study presents an extended sample of 129 subjects (66 subjects have been previously reported): 19 patients with SCZ or schizoaffective disorder, 30 unaffected first-degree relatives of these SCZ patients, 13 obsessive-compulsive disorder (OCD) patients, 18 unaffected first-degree relatives of these OCD patients and 49 healthy subjects. In the DLPFC, cortical inhibition was significantly decreased in patients with SCZ compared to healthy subjects. First-degree relatives of patients with SCZ showed significantly more cortical inhibition than their SCZ probands. No differences were demonstrated between first-degree relatives of SCZ patients and healthy subjects. Taken together, these findings show that more studies are needed to establish an objective biological marker for potential diagnostic usage in severe psychiatric disorders.
Intranasal administration of a two-dose adjuvanted multi-antigen TMV-subunit conjugate vaccine fully protects mice against Francisella tularensis LVS challenge (2018)

Tularemia is a fatal human disease caused by Francisella tularensis, a Gram-negative encapsulated coccobacillus bacterium. Due to its low infectious dose, ease of aerosolized transmission, and lethal effects, the CDC lists F. tularensis as a Category A pathogen, the highest level for a potential biothreat agent. Previous vaccine studies have been conducted with live attenuated, inactivated, and subunit vaccines, which have achieved partial or full protection from F. tularensis live vaccine strain (LVS) challenge, but no vaccine has been approved for human use. We demonstrate the improved efficacy of a multi-antigen subunit vaccine by using Tobacco Mosaic virus (TMV) as an antigen carrier for the F. tularensis SchuS4 proteins DnaK, OmpA, SucB and Tul4 (DOST). The magnitude and quality of immune responses were compared after mice were immunized by subcutaneous or intranasal routes of administration with a TMV-DOST mixture, with or without four different adjuvants. Immune responses varied in magnitude and isotype profile, by antigen, by route of administration, and by protection in an F. tularensis LVS challenge model of disease. Interestingly, our analysis demonstrates an overwhelming IgG2 response to SucB after intranasal dosing, as well as a robust cellular response, which may account for the improved two-dose survival imparted by the tetravalent vaccine, compared to a previous study that tested efficacy of TMV-DOT. Our study provides evidence that potent humoral, cellular and mucosal immunity can be achieved by optimal antigen combination, delivery, adjuvant and appropriate route of administration, to improve vaccine potency and provide protection from pathogen challenge.
Cultivating Shared Services - Four Winds Digital Signage (2015)

By establishing a partnership between a variety of units on the College Station campus, we successfully partnered with Four Winds Interactive, a leading provider of digital signage, to provide a shared service that leverages the buying power of multiple units, the technical power of a shared installation, and the collaborative power of an IT governance model. This presentation will detail the model used to create a successful shared service that benefits a variety of audiences, both internal and external.
A Moldy Application of MALDI: MALDI-ToF Mass Spectrometry for Fungal Identification (2019)

As a result of its being inexpensive, easy to perform, fast and accurate, matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-ToF MS) is quickly becoming the standard means of bacterial identification from cultures in clinical microbiology laboratories. Its adoption for routine identification of yeasts and even dimorphic and filamentous fungi in cultures, while slower, is now being realized, with many of the same benefits as have been recognized on the bacterial side. In this review, the use of MALDI-ToF MS for identification of yeasts, and dimorphic and filamentous fungi grown in culture will be reviewed, with strengths and limitations addressed.
hPEBP4 Resists TRAIL-induced Apoptosis of Human Prostate Cancer Cells by Activating Akt and Deactivating ERK1/2 Pathways (2006)

The treatment options available for prostate cancer are limited because of its resistance to therapeutic agents. Thus, a better understanding of the underlying mechanisms of the resistance of prostate cancer will facilitate the discovery of more efficient treatment protocols. Human phosphatidylethanolamine-binding protein 4 (hPEBP4) is recently identified by us as an anti-apoptotic molecule and a potential candidate target for breast cancer treatment. Here we found the expression levels of hPEBP4 were positively correlated with the severity of clinical prostate cancer. Furthermore, hPEBP4 was not expressed in TRAIL-sensitive DU145 prostate cancer cells, but was highly expressed in TRAIL-resistant LNCaP cells, which show highly activated Akt. Interestingly, hPEBP4 overexpression in TRAIL-sensitive DU145 cells promoted Akt activation but inhibited ERK1/2 activation. The hPEBP4-overexpressing DU145 cells became resistant to TRAIL-induced apoptosis consequently, which could be reversed by PI3K inhibitors. In contrast, silencing of hPEBP4 in TRAIL-resistant LNCaP cells inhibited Akt activation but increased ERK1/2 activation, resulting in their sensitivity to TRAIL-induced apoptosis that was restored by the MEK1 inhibitor. Therefore, hPEBP4 expression in prostate cancer can activate Akt and deactivate ERK1/2 signaling, leading to TRAIL resistance. We also demonstrated that hPEBP4-mediated resistance to TRAIL-induced apoptosis occurred downstream of caspase-8 and at the level of BID cleavage via the regulation of Akt and ERK pathways, and that hPEBP4-regulated ERK deactivation was upstream of Akt activation in prostate cancer cells. Considering that hPEBP4 confers cellular resistance to TRAIL-induced apoptosis and is abundantly expressed in poorly differentiated prostate cancer, silencing of hPEBP4 suggests a promising approach for prostate cancer treatment.
Borrowing Constraints and Credit Demand (2010)

Este artículo analiza los determinantes de la demanda por crédito en presencia de\nrestricciones crediticias para la economía chilena utilizando una reciente e innovativa\nfuente de información: la Encuesta Financiera de Hogares. El procedimiento de estimación\nimplementado permite que la deuda observada sea una función de múltiples reglas de\nselección e incorpora endogeneidad de ingreso y activos en la ecuación de deuda. El\nartículo provee evidencia contundente acerca de la relación altamente no lineal entre el\ningreso de los hogares y su deuda, tanto asegurada como no asegurada. Este resultado tiene\nclaras implicancias para el nivel de endeudamiento de los hogares en presencia de\ndesregulación financiera.
Effect of Poloxamer 188 vs Placebo on Painful Vaso-Occlusive Episodes in Children and Adults With Sickle Cell Disease (2021)

ClinicalTrials.gov Identifier: NCT01737814.
Evaluation of an Electronic Device for Real-Time Measurement of Alcohol-Based Hand Rub Use (2009)

The use of these electronic devices provided an efficient and accurate method of monitoring the frequency of alcohol-based hand rub performance on the general medical ward and in the surgical intensive care unit, and yielded more detailed information on usage patterns than did expressing use as liters per 1,000 patient-days. The wireless downloading of data from dispensers required a limited amount of time, and the dedicated Web site facilitated data analysis. Such devices should prove useful in monitoring the impact of various interventions on the frequency of hand hygiene performance.
Spiraltron Matrices as Windowless Photon Detectors for Soft X-Ray and Extreme UV (1969)

The principal problems associated with detecting low energy photons and charged particles are summarized, and the potential advantages to be gained by using channel electron multipliers to detect such radiation are discussed. Operating characteristics of the recently developed Spiraltron electron multiplier are also described. Spiraltrons incorporate all the operating characteristics of curved channel electron multipliers, but possess a straight geometric configuration that allows them to be stacked into large matrices. Such matrices have a peaked gain distribution (FWHM ≈ 90 percent), high mean gain (≈ 107), and low dark noise (3 counts/second/cm2) making them ideal for detecting low energy radiation from spacially dispersed sources.
Cavity dynamics in high-speed water entry (1997)

A method is presented for modeling the cavity formation and collapse induced by high-speed impact and penetration of a rigid projectile into water. The approach proposes that high-speed water-entry is characterized by a cavity that experiences a deep closure prior to closure at the surface. This sequence in the physical events of the induced cavity dynamics is suggested by the most recent high-speed water-entry experimental data, by results from numerical experiments using a hydrocode, and by an understanding of the fundamental physics of the processes that govern surface closure. The analytical model, which specifies the energy transfer for cavity production as equivalent to the energy dissipated by velocity-dependent drag on the projectile, provides accurate estimates for variables that are important in characterizing the cavity dynamics, and reveals useful knowledge regarding magnitudes and trends. In particular, it is found that the time of deep closure is essentially constant and independent of the impact velocity for a given projectile size, while the location of deep closure has a weak dependence on impact velocity. Comparison of these analytical results with experimental results from the literature and with results from numerical simulations verifies the analytical solutions.
Metallic conductivity at the CaHfO3∕SrTiO3 interface (2007)

The transport and photoluminescence properties of interfaces between amorphous CaHfO3 films and SrTiO3 single crystal substrates were investigated. Although both materials are band-gap insulators, the interfaces were metallic. The sheet carrier density was found to depend strongly on the laser fluence used during the CaHfO3 layer fabrication by pulsed laser deposition, indicating the presence of oxygen vacancies at the interface. The Hall mobility of the heterostructures saturated at 2000cm2∕Vs at low temperature. Photoluminescence spectra showed an oxygen vacancy-related emission band at around 420nm.
Robot Task Allocation based on Greedy-Face-Greedy Algorithm (2019)

International audience
A Novel Efficient Big Data Processing Scheme for Feature Extraction in Electrical Discharge Machining (2019)

Electrical discharge machining (EDM) can machine hard conductive workpieces that are difficult to machine using traditional machining techniques. For monitoring the EDM process using virtual metrology (VM), probes with a very high sampling rate are needed to acquire the voltage and current signals of electrodes, thereby generating a huge amount of sensor data and raising a big data processing issue in extracting features from raw sensor data. This paper proposes a novel efficient big data processing scheme for feature extraction in EDM, called BEDPS, based on Spark and HDFS. A parallel gap-based wave detection mechanism using Spark is designed to efficiently detect effective machining waves from big machining raw data of EDM without the slow internode data communications in HDFS. A pre-loaded memory-based feature calculation mechanism is also developed to calculate the key features from machining-wave data in Spark in a parallel-processing manner. Testing results show that the proposed BEDPS is much more efficient in terms of total execution time in machining wave detection and feature calculation and more scalable in the data size that can be processed, compared to the existing system.
Incommensurate ordering in Ca-Sr-Bi-Cu oxide superconductors (1988)

High temperature superconductivity in non-rare earth ceramic oxides has been recently reported, however the structure and composition of the phase(s) has yet to be unequivocally identified. In the Ca-Sr-Bi-Cu Oxide system onset transition temperatures as high as 120 K have been reported, in both single and multiphase specimens. In this work we report on preliminary AEM-based studies of single and polycrystalline specimens of Ca-Sr-Bi-Cu Oxide superconductors. The superconducting material was prepared by mixing powders of Bi 2 O 3 , CaCO 3 , SrCO 3 , and CuO; and then processed by repeated grinding, heating in either flowing oxygen or air followed by furnace cooling as described in detail elsewhere. The superconducting phase(s) in the powder (∽0.5 x 20μm) specimens are dark, elongated layered crystals which exhibit pronounced basal plane cleavage similiar to graphite or clay based minerals. Larger nominally single crystal specimens (∽0.5 - 2 mm) are less regular in shape, however, all other macroscopic characteristics are essentially the same.
Induction and attenuation of neuronal apoptosis by proteasome inhibitors in murine cortical cell cultures (2005)

Evidence has accumulated showing that pharmacological inhibition of proteasome activity can both induce and prevent neuronal apoptosis. We tested the hypothesis that these paradoxical effects of proteasome inhibitors depend on the degree of reduced proteasome activity and investigated underlying mechanisms. Murine cortical cell cultures exposed to 0.1 microM MG132 underwent widespread neuronal apoptosis and showed partial inhibition of proteasome activity down to 30-50%. Interestingly, administration of 1-10 microM MG132 almost completely blocked proteasome activity but resulted in reduced neuronal apoptosis. Similar results were produced in cortical cultures exposed to other proteasome inhibitors, proteasome inhibitor I and lactacystin. Administration of 0.1 microM MG132 led to activation of a mitochondria-dependent apoptotic signaling cascade involving cytochrome c, caspase-9, caspase-3 and degradation of tau protein; such activation was markedly reduced with 10 microM MG132. High doses of MG132 prevented the degradation of inhibitor of apoptosis proteins (IAPs) cIAP and X chromosome-linked IAP, suggesting that complete blockade of proteasome activity interferes with progression of apoptosis. In support of this, addition of high doses of proteasome inhibitors attenuated apoptosis of cortical neurons deprived of serum. Taken together, the present results indicate that inhibition of proteasome activity can induce or prevent neuronal cell apoptosis through regulation of mitochondria-mediated apoptotic pathways and IAPs.