gebhart/patrepeval huggingface dataset:
Brain glial activation in fibromyalgia – A multi-site positron emission tomography investigation (2018)

Fibromyalgia (FM) is a poorly understood chronic condition characterized by widespread musculoskeletal pain, fatigue, and cognitive difficulties. While mounting evidence suggests a role for neuroinflammation, no study has directly provided evidence of brain glial activation in FM. In this study, we conducted a Positron Emission Tomography (PET) study using [<sup>11</sup>C]PBR28, which binds to the translocator protein (TSPO), a protein upregulated in activated microglia and astrocytes. To enhance statistical power and generalizability, we combined datasets collected independently at two separate institutions (Massachusetts General Hospital [MGH] and Karolinska Institutet [KI]). In an attempt to disentangle the contributions of different glial cell types to FM, a smaller sample was scanned at KI with [<sup>11</sup>C]-<sub>L</sub>-deprenyl-D<sub>2</sub> PET, thought to primarily reflect astrocytic (but not microglial) signal. Thirty-one FM patients and 27 healthy controls (HC) were examined using [<sup>11</sup>C]PBR28 PET. 11 FM patients and 11 HC were scanned using [<sup>11</sup>C]-<sub>L</sub>-deprenyl-D<sub>2</sub> PET. Standardized uptake values normalized by occipital cortex signal (SUVR) and distribution volume (V<sub>T</sub>) were computed from the [<sup>11</sup>C]PBR28 data. [<sup>11</sup>C]-<sub>L</sub>-deprenyl-D<sub>2</sub> was quantified using λ k<sub>3</sub>. PET imaging metrics were compared across groups, and when differing across groups, against clinical variables. Compared to HC, FM patients demonstrated widespread cortical elevations, and no decreases, in [<sup>11</sup>C]PBR28 V<sub>T</sub> and SUVR, most pronounced in the medial and lateral walls of the frontal and parietal lobes. No regions showed significant group differences in [<sup>11</sup>C]-<sub>L</sub>-deprenyl-D<sub>2</sub> signal, including those demonstrating elevated [<sup>11</sup>C]PBR28 signal in patients (p's ≥ 0.53, uncorrected). The elevations in [<sup>11</sup>C]PBR28 V<sub>T</sub> and SUVR were correlated both spatially (i.e., were observed in overlapping regions) and, in several areas, also in terms of magnitude. In exploratory, uncorrected analyses, higher subjective ratings of fatigue in FM patients were associated with higher [<sup>11</sup>C]PBR28 SUVR in the anterior and posterior middle cingulate cortices (p's < 0.03). SUVR was not significantly associated with any other clinical variable. Our work provides the first in vivo evidence supporting a role for glial activation in FM pathophysiology. Given that the elevations in [<sup>11</sup>C]PBR28 signal were not also accompanied by increased [<sup>11</sup>C]-<sub>L</sub>-deprenyl-D<sub>2</sub> signal, our data suggests that microglia, but not astrocytes, may be driving the TSPO elevation in these regions. Although [<sup>11</sup>C]-<sub>L</sub>-deprenyl-D<sub>2</sub> signal was not found to be increased in FM patients, larger studies are needed to further assess the role of possible astrocytic contributions in FM. Overall, our data support glial modulation as a potential therapeutic strategy for FM.
DC-link current control scheme for paralleled three-phase current source rectifiers in high efficiency power supply system (2013)

Three-phase current source rectifier (CSR) is a promising solution for power supply systems as the buck-type power factor correction converter. By converter paralleling, high power rating and system redundancy can be achieved. However, asymmetrical distribution of load current among converter modules may occur, which can increase power loss or even damage devices. This paper presents the DC-link current control scheme for paralleled current source rectifiers to balance the output currents. Using a master-slave control, the balanced output current distribution and system redundancy are implemented. By correcting zero state duration based on modulation scheme, the circulating current is suppressed without introducing additional power losses, and both positive and negative DC-link currents are balanced.
C6–C8 Bridged Epothilones: Consequences of Installing a Conformational Lock at the Edge of the Macrocycle (2011)

A series of conformationally restrained epothilone analogues with a short bridge between the methyl groups at C6 and C8 was designed to mimic the binding pose assigned to our recently reported EpoA-microtubule binding model. A versatile synthetic route to these bridged epothilone analogues has been successfully devised and implemented. Biological evaluation of the compounds against A2780 human ovarian cancer and PC3 prostate cancer cell lines suggested that the introduction of a bridge between C6-C8 reduced potency by 25-1000 fold in comparison with natural epothilone D. Tubulin assembly measurements indicate these bridged epothilone analogues to be mildly active, but without significant microtubule stabilization capacity. Molecular mechanics and DFT energy evaluations suggest the mild activity of the bridged epo-analogues may be due to internal conformational strain.
Homogeneous gas-phase pyrolyses using a wall-less reactor. I. Neopentane (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHomogeneous gas-phase pyrolyses using a wall-less reactor. I. NeopentaneJay Eugene Taylor, David A. Hutchings, and Kenneth J. FrechCite this: J. Am. Chem. Soc. 1969, 91, 9, 2215–2219Publication Date (Print):April 1, 1969Publication History Published online1 May 2002Published inissue 1 April 1969https://pubs.acs.org/doi/10.1021/ja01037a005https://doi.org/10.1021/ja01037a005research-articleACS PublicationsRequest reuse permissionsArticle Views59Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Chemokines in proliferative diabetic retinopathy and proliferative vitreoretinopathy. (2006)

MCP-1, IP-10 and SDF-1 may participate in pathogenesis of PVR and PDR. Myofibroblasts and vascular endothelial cells are the major cell types expressing MCP-1, SDF-1, and CXCR3 in epiretinal membranes.
Postnatal Expansion of the Pancreatic β-Cell Mass Is Dependent on Survivin (2008)

Our findings implicate survivin in the maintenance of beta-cell mass through both replication and antiapoptotic mechanisms. Given the widespread involvement of survivin in cancer, a novel role for survivin may well be exploited in beta-cell regulation in diseased states, such as diabetes.
Real - time data collection and information generation using airborne sensors (2008)

In this chapter we review existing airborne platforms and sensors, as well as the products that can be generated from the data they acquire, and assess their utility in the context of emergency response. Airborne remote sensing has a much longer history then satellite-based Earth observation, which has led to the development of a wide variety of vehicles that can carry different sensors, ranging from tethered balloons to Unmanned Aerial Vehicles (UAVs) that operate at stratospheric heights. We base our evaluation on a number of objective assessment criteria that include technical and commercial aspects, as well as various considerations for emergency response, such as required processing time or use for a given disaster type. We specifically show how different emergencies can lead to a range of observable consequences that call for suitably adapted remote sensing tools, and how more sophisticated products, e.g. 3D or 4D, or integrated in a GIS environment, can lead to improved response capability. We review the use of optical, thermal, laser scanning and radar data, and show how they are best suited for different disaster scenarios. Thus the decision on which data type or product to use in a given emergency situation is a multi-criteria problem that requires good understanding of the available information types, their utility for the disaster in question, but also practical and flexible thinking to identify potential alternatives. We show that airborne remote sensing has great potential to aid in an emergency situation, though also note that the provision of value-added products within the 3 day response window we consider here will not always be possible. We conclude with a table that summarises the relevant characteristics of the main remote sensing data types and products with respect to their suitability for different disaster types, which can serve as guidance for decision makers.
Growth Deficits and Attention-Deficit/Hyperactivity Disorder Revisited: Impact of Gender, Development, and Treatment (2003)

No growth deficits appear to be associated with ADHD or its treatment in females. These findings add to a growing literature supporting the notion that stimulant treatment does not have an adverse impact on ADHD children's growth and development.
From Understanding to Prediction: Gold- and Platinum-Based π-Acid Catalysis for Target Oriented Synthesis (2013)

During the last century, conceptual advances in organometallic chemistry were often rapidly embraced by target oriented synthesis. Feedback provided by such preparative scrutiny has greatly benefitted method development; particularly prominent are examples from the entire cross coupling arena, as well as olefin metathesis. Seen against this backdrop, it is somewhat surprising that the explosive growth of research into π-acid catalysis has not yet yielded a matching number of implementations into the synthesis of structurally complex targets of biological significance. In contrast to the massive output of methodological and mechanistic investigations, few studies illustrate the strategic use of gold, silver, or platinum catalysis in late stages of such multistep endeavors. These elaborate and highly precious compounds demand utmost confidence in the reliability and robustness of the method to be applied. In this Account, we analyze the possible reasons for this imbalance, after a short summary of the conceptual basis of carbophilic activation of π-bonds with the aid of soft transition metal cations or complexes. We pinpoint mechanistic subtleties, which, at least in part, produce a great deal of structural diversity but can jeopardize predictive power. With the advances in the understanding of π-acid catalyzed processes in general, however, this uncertainty is gradually vanishing and the entire field is transitioning from comprehension to prediction. This is expected to foster advanced applications, while recent progress in asymmetric gold catalysis further improves the preparative significance. The presented work in this Account illustrates our own commitment to the field as well as our growing confidence in the maturity of platinum and gold catalysis. The carbophilic activation of π-bonds, particularly of alkynes, provides a method to manipulate functional groups that is orthogonal to traditional carbonyl chemistry. We illustrate this notion by presenting a new approach to hydroxypyrone derivatives that has enabled the total synthesis of the fragile polyunsaturated cyclophane derivative neurymenolide A. The synthesis of the pyrrole alkaloid streptorubin by an enyne cycloisomerization is equally instructive. In addition, different manifestations of transannular hydroxyl addition reactions across alkyne partners mark the late stages of our conquests of amphidinolide F, polycavernoside A, and spirastrellolide F. Together with a few model studies and a personal selection of recent highlights from other groups, these examples augur well for future applications of π-acid catalysts in the realm of target oriented synthesis.
Characterization of luminous-cubic boron-nitride single-crystals doped with Eu3+ and Tb3+ ions (2005)

Incorporation of Eu3+ and Tb3+ ions into single crystals of cubic boron nitride (c-BN) has been performed by mixing these fluorides into a solvent for crystal growth of c-BN under high pressure. This method consequently brings luminous features into c-BN. The doped c-BN single crystals show no discernible structural changes in their matrices, while their elements are incorporated into the whole of crystals in atomic scale. Photoluminescence spectra of c-BN:Eu and c-BN:Tb exhibit the intra-4f electron transitions of Eu3+ and Tb3+ ions, starting from their excitation levels, D05 and D45, respectively.
Protein–Polyelectrolyte Interaction: Thermodynamic Analysis Based on the Titration Method † (2019)

This review discussed the mechanisms including theories and binding stages concerning the protein⁻polyelectrolyte (PE) interaction, as well as the applications for both complexation and coacervation states of protein⁻PE pairs. In particular, this review focused on the applications of titration techniques, that is, turbidimetric titration and isothermal titration calorimetry (ITC), in understanding the protein⁻PE binding process. To be specific, by providing thermodynamic information such as pH<sub>c</sub>, pH<sub>φ</sub>, binding constant, entropy, and enthalpy change, titration techniques could shed light on the binding affinity, binding stoichiometry, and driving force of the protein⁻PE interaction, which significantly guide the applications by utilization of these interactions. Recent reports concerning interactions between proteins and different types of polyelectrolytes, that is, linear polyelectrolytes and polyelectrolyte modified nanoparticles, are summarized with their binding differences systematically discussed and compared based on the two major titration techniques. We believe this short review could provide valuable insight in the understanding of the structure⁻property relationship and the design of applied biomedical PE-based systems with optimal performance.
Intravesical Toll‐like receptor 7 agonist R‐837: Optimization of its formulation in an orthotopic mouse model of bladder cancer (2010)

The optimized poloxamer-HPbetaCD formulation of R-837 shows therapeutic potential for bladder cancer while avoiding adverse side-effects.
The reflectarray antenna (1963)

A class of antennas that utilizes arrays of elementary antennas as reflecting surfaces has been investigated. An antenna of this type is here called a Reflectarray. It has been found that the Reflectarray combines much of the simplicity of the reflector-type antenna with the performance versatility of the array type. The reflecting surfaces employed in these antennas are characterized by a surface impedance that can be synthesized to produce a variety of radiation patterns. The equations of the surface impedance as a function of the desired reflected phase front is derived for the lossless case and methods of realizing this surface impedance are presented. Experimental results of a waveguide array type Reflectarray are given including pencil beam, broad beam and scanning modes. Data on the effects of specific phase errors are presented.
HUMORAL IMMUNITY TO HUMAN NEOPLASMS (1974)

Using complement fixation technique, serial serum samples from 15 patients undergoing surgical removal of malignant tumors were assayed for the presence of tumors antibodies against the cellular fractions of both normal and carcinomatous tissue. Antibody responses against tumor associated antigens were detected in four cases. In all cases antibody activity was directed only against the supernatant of the carcinomatous tissue from the same indivi&amp;shy;dual.
GroMoPo : A Groundwater Model Portal for Findable, Accessible, Interoperable, and Reusable (FAIR) Modeling (2023)

Data S1 Supporting information. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Search for supersymmetry in events with a photon, a lepton, and missing transverse momentum in pp collisions at s=8 TeV (2016)

A search for supersymmetry involving events with at least one photon, one electron or muon, and large missing transverse momentum has been performed by the CMS experiment. The data sample corresponds to an integrated luminosity of 19.7 fb -1 of pp collisions at s = 8 TeV, produced at the CERN LHC. No excess of events is observed beyond expectations from standard model processes. The result of the search is interpreted in the context of a general model of gauge-mediated supersymmetry breaking, where the charged and neutral winos are the next-to-lightest supersymmetric particles. Within this model, winos with a mass up to 360 GeV are excluded at the 95% confidence level. Two simplified models inspired by gauge-mediated supersymmetry breaking are also examined, and used to derive upper limits on the production cross sections of specific supersymmetric processes.
Transient antibodies to DNA polymerase in acute hepatitis B and related diseases. (1976)

Sera from patients with acute hepatitis, cirrhosis or chronic hepatitis, as well as sera from healthy carriers and controls were examined for HBS antigen, DNA polymerase activity and for antibodies to HBS, HBC and DNA polymerase. The data presented suggest that in acute hepatitis the DNA polymerase test enabled us to diagnose at least 20% more cases of hepatitis B than with the RIA but that the DNA polymerase test is of little value for the screening of blood donors since all the healthy carriers gave negative results. As concerns the antibodies to DNA polymerase they appeared in at least 50% of the patients with acute hepatitis, they were transient and only detectable at the early beginning of the disease. These antibodies were also found to be different from the anti-HBS and anti-HBC antibodies.
What predicts poor outcome after successful thrombectomy in late time windows? (2020)

The absence of a penumbra defined by a NoMM profile on baseline imaging appears to be an independent predictor of poor outcome after reperfusion. Strategies aiming to preserve the penumbra may be encouraged to improve these patients' outcomes.
Topographical control of ocular cell types for tissue engineering (2013)

Visual impairment affects over 285 million people worldwide and has a major impact on an individual's quality of life. Tissue engineering has the potential to increase the quality of life for many of these patients by preventing vision loss or restoring vision using cell-based therapies. However, these strategies will require an understanding of the microenvironmental factors that influence cell behavior. The eye is a well-organized organ whose structural complexity is essential for proper function. Interactions between ocular cells and their highly ordered extracellular matrix are necessary for maintaining key tissue properties including corneal transparency and retinal lamination. Therefore, it is not surprising that culturing these cells in vitro on traditional flat substrates result in irregular morphology. Instead, topographically patterned biomaterials better mimic native extracellular matrix and have been shown to elicit in vivo-like morphology and gene expression which is essential for tissue engineering. Herein we review multiple methods for producing well-controlled topography and discuss optimal biomaterial scaffold design for cells of the cornea, retina, and lens.
Analytic comparison of four robust algorithms for post-detection integration (1992)

Four radar integration algorithms are compared with the basic moving window (video) integrator. The algorithms are robust in the sense of immunity against strong interfering spikes. Very strong spikes can appear if several radars operate in close proximity. The algorithms have been previously suggested for integration or are borrowed from CFAR thresholding methods. This paper provides an analytic performance analysis for a simple signal (Swerling II), noise and interference model. The comparison of the four algorithms, in the situation covered by this model, may be indicative of their relative performances in more realistic models, for which it is more difficult to obtain closed-form results.
Avant-propos : Littérature inter-testamentaire et nouveau testament hommage à Marc Philonenko a l'occasion de son soixante-dixième anniversaire (2000)

Grappe Christian, Vincent Gilbert. Avant-propos : Littérature inter-testamentaire et nouveau testament hommage à Marc Philonenko a l'occasion de son soixante-dixième anniversaire . In: Revue d'histoire et de philosophie religieuses, 80e année n°1, Janvier-mars 2000. Hommage à Marc Philonenko. pp. 2-4.
Measurement and Correlation of Phase Equilibria for the Carbon Dioxide-Ethanol-Water System. (1993)

Phase equilibria for the carbon dioxide-ethanol system and the carbon dioxide-ethanol-water system were measured to provide the thermodynamic base for the extraction of ethanol from its aqueous solutions using near-critical carbon dioxide as solvent. The experiments were carried out at 283 K–298 K and 5–7 MPa, including extraction conditions and solvent-recovery conditions in a wide range of ethanol concentration.An empirical mixing rule for the Helmholtz function with ternary as well as binary non-randomness parameters was proposed based on the density-dependent local composition concept. A correlation model was derived by a combination of the mixing rule with the Helmholtz function obtained from the Patel-Teja equation of state. The model successfully correlated the phase equilibria of the carbon dioxide-ethanol-water system.
Análisis de una red de transporte de gas (2007)

Growing demand for natural gas necessarily leads to demands for increased transport network capacity. This can be done by increasing the capacity of already installed gas pipelines and optimising operating conditions. Greater knowledge (know-how) regarding the process is thus needed and may be applied by following the procedure outlined in this work. The proposed method concerns studying a gas network by using simulation tools; it has been used for studying a transport network in Argentina. The proposed method has the following stages: 1) system analysis (identifying parameters, disturbances, manipulated variables, state variables and output variables), 2) stationary simulation, 3) dynamic simulation and 4) case studies (analysing sensitivity, stability and controllability) . Once a system’s critical variables have been identified then stationary simulation allows the amount of gas and its pressure to be determined for each sink, in several scenarios. These results can be used for designing suitable operational procedure for such cases. Dynamic simulation describes a system’s stationary state and how the state of the process evolves. Such additional information allows refining previously-designed procedures and also makes dynamic simulation an excellent tool for operator training. Two alternatives were analysed for stationary simulation: an HYSYS simulator and traditional Excel spreadsheet calculations. Predicted stationary states were similar by both methods. The sensitivity of the most relevant system variables was then studied; the HYSYS simulator was used for dynamic simulation in all cases. System sensitivity and dynamics were determined, such information being required for making improvements to network installations and operational procedures and thereby proving the procedure’s worth.