gebhart/patrepeval huggingface dataset:
Storage pool deficiency in cattle with the Chediak-Higashi syndrome results from an absence of dense granule precursors in their megakaryocytes (1988)

Platelets from cattle with the Chédiak-Higashi syndrome (CHS) have a storage pool deficiency and virtual absence of platelet dense granules. Megakaryocytes (MKs) from five control (n = 135) and five CHS (n = 133) cattle were evaluated using standard transmission electron microscopy. Osmiophilic dense granules were not observed in control or CHS MKs. In MKs from normal cattle, clear vesicles of 200- to 650-nm diameter bounded by a sharp membrane were observed. They were easily differentiated from the demarcation membrane system, endoplasmic reticulum, and alpha granules. The clear vesicles were virtually absent in MKs from CHS cattle at all stages of maturation. MKs in bone marrow samples from two control (n = 91) and two CHS (n = 61) cattle that had been processed for the uranaffin reaction were also evaluated. The clear vesicles were replaced by uranaffin-positive granules in MKs from control cattle, but positive uranaffin granules were not observed in CHS MKs. These findings indicate that the platelet dense granule storage pool deficiency in CHS cattle results from an anatomic absence of dense granule precursors in maturing and mature CHS MKs.
Evaluation of master equations for the droplet size distribution in condensing flow (2009)

The kinetic equation (KE) and its first- and second-order approximations, the general dynamic equation (GDE), and the Fokker–Planck equation (FPE), respectively, have been evaluated based on (a) their equilibrium distributions, (b) a nucleation pulse experiment, and (c) an expanding nozzle flow. Large differences are observed between the equilibrium distributions of the FPE and KE, whereas the GDE does not have an equilibrium distribution at all. For the nucleation pulse experiment, good agreement is found between the KE, FPE, and GDE due to quasisteady nucleation. For the condensing nozzle flow, the difference between the GDE and the KE distributions is large, although the relevant flow variables show fair agreement. A sensitivity study of the KE solution with respect to uncertainties in (a) the surface tension model, (b) the sticking probability, and (c) the equilibrium distribution revealed that both the sticking probability and the equilibrium distribution have a significant influence on the predicted condensation onset. Furthermore, it is found that the proposed Wölk and Strey-corrected Courtney equilibrium distribution yields the best agreement with the reported measurements.
Induction of Synovitis Using Interleukin-1 Beta: Are There Differences in the Response of Middle Carpal Joint Compared to the Tibiotarsal Joint? (2018)

<b>Background:</b> The effects of recombinant interleukin-1β (rIL-1β) have been described for the middle carpal joint (MCJ). However, we are unaware of any studies that have described the cytological response of the tibiotarsal joint (TTJ) to rIL-1β or compared the clinical and cytological responses of the MCJ to the TTJ following the administration of intra-articular rIL-1β. Such information is critical for researchers planning to use rIL-1β to create acute synovitis models in horses. <b>Objectives:</b> To compare the clinical and cytological responses of the MCJ to the TTJ following administration of intra-articular rIL-1β. <b>Methods:</b> Twelve horses were used for the study. Eight horses received 75 ng of rIL-1β into the MCJ and four horses received 75 ng of rIL-1β into the TTJ. Clinical and cytological outcome parameters including lameness, joint circumference, joint effusion score, total nucleated cell count, cellular differentials, C-reactive protein, and prostaglandin-E2 concentrations were determined at baseline and multiple post-treatment time points over a 336 h period (2 weeks). <b>Results:</b> Recombinant IL-1β administered into the TTJ resulted in a significantly greater respiratory rate at 24 h and heart rate at 12 h when compared to rIL-1β administered into the MCJ. In addition, the TTJ had a significantly greater increase in joint circumference at 24 post-injection hour (PIH) and subjective effusion grade at 24 PIH and 336 PIH. The MCJ had significantly higher total protein concentration at 6 PIH, and a significantly higher NCC at 24 and 72 PIH when compared to the TTJ. Conversely, the TTJ had significantly higher neutrophilic infiltration than the MCJ at 6 PIH and 168 PIH. <b>Conclusions:</b> This study establishes that the same intra-articular dose of rIL-1 β elicits significantly different clinical and cytological responses in the MCJ compared to the TTJ in the equine model of intra-articular synovitis. In addition, clinical and cytological evidence of synovitis may persist up to or >1 week following intra-articular administration of rIL-1 β.
Fuzzy-timing Petri net model of temperature control for car air conditioning system (2003)

This paper proposes a fuzzy-timing Petri net method for distributed temperature control to achieve optimum air temperatures inside a car, considering the comfort of each passenger. The optimum HVAC control has been applied to a car air conditioning system, and a fuzzy controller is used to independently control temperatures at various locations inside the car, considering each passenger's comfort temperature level and the air velocity at each seat. We have conducted experiments and confirmed that our method is useful for distributed temperature control in a car.
Supplementary movie 2 Adjacent tumor spheroids disorganize and migrate on CAF networks from Cancer-Associated Fibroblasts Induce a Collagen Cross-link Switch in Tumor Stroma (2023)

&lt;p&gt;A Matrigel surface was seeded first with GFP-tagged aggregates followed 24 h later by a CAF single-cell suspension. Time-lapse microscopy was initiated 24 hours after CAF seeding. Dissociating tumor aggregates migrate toward each other (arrow). Scale bar, 100 μm. Movie compiled at 2 frames per second.&lt;/p&gt;
Marshall Islands farming expansion: New hatchery, new atolls, new techniques (1998)

Refinements in handling of early spat both on the farm and in the nursery have resulted in improved survival and growth of these animals. The landbased nursery usually results in better survival, but the animals grow more slowly than those held on the farm. Plans for a larger-capacity nursery system are being implemented in stages, to provide increased algal production, higher flow-through rates and greater nursery holding-tank capacity. A large-scale permanent hatchery facility will also be built in the coming year.
Light Trapping in Bifacial Solar Modules Using Effectively Transparent Contacts (ETCs) (2018)

We have performed a computational study on the enhancement of the light absorption within bifacial solar modules with effectively transparent contacts (ETCs). ETCs are triangular cross-section silver fingers that redirect light to the active area of the solar cell and therefore, mitigate finger grid shading losses. Furthermore, ETCs can be spaced densely leading to light trapping. We used a combination of thin film and ray optical simulations and determined that light absorption can be increased by more than 4.5% compared to state-of-the-art metallization due to light trapping and effective transparency. Furthermore, we calculated that grid resistance and silver usage can be improved when using ETCs.
Toxicity and anti-tumor activity of hydrophobic diammine and diaminocyclohexane platinum complexes entrapped in multilamellar vesicles. (1988)

The toxicity and anti-tumor activity of a lipophilic diaminocyclohexane (DACH) platinum complex entrapped in liposomes (liposomal-cis-bis-neodecanoato-trans-R, R-1, 2-DACH platinum II-L-NDDP) were compared with those of the liposomal preparation of the same compound without the DACH group (liposomal-cis-bis-neodecanoato-(diammine) platinum II-L-CNDP). Both liposomal preparations had the same liposome size distribution, drug entrapment efficiency (greater than 95%), and liposome stability (greater than 95%). Although no differences were observed in the mouse LD50 (60.2 mg/kg for L-NDDP vs 67.8 mg/kg for L-CNDP), the liposome entrapped non-DACH compound (L-CNDP) was more nephrotoxic than the liposome entrapped DACH compound (L-NDDP), but much less than cisplatin (CDDP) (mean BUN elevation 4 days after the administration of the LD50 dose 67 mg% for L-CNDP vs 30 mg% for L-NDDP vs 255 mg% for CDDP). L-NDDP was not cross-resistant with CDDP against L1210/CDDP leukemia while L-CNDP was cross-resistant (%T/C 200 for L-NDDP, 112 for CDDP, and 100 for L-CNDP). In addition, L-NDDP was slightly more active than L-CNDP against i.p. L1210/0 leukemia and i.v. M5076 reticulosarcoma. These studies suggest that the attachment of a cyclohexane group to the amino functions of lipophilic platinum complexes results in a decrease of the nephrotoxicity and a lack of cross-resistance with CDDP. The lack of cross-resistance is preserved when the compounds are entrapped and delivered in a liposomal carrier but not when they are delivered in a micellar suspension.
D6.1. Impacts monitoring, dynamic asessment and evaluation. Deliverable to the AEOLIX project. (2018)

The main purpose of this deliverable is to present the evaluation framework of the AEOLIX platform. The evaluation framework is built based on the eleven Living Labs and will rely on a two-level assessment: the operational benefits in terms of business advantages derived from the implementation of the Living Labs and a mechanism called “Dynamic Impact Monitoring” which will monitor and assess the market penetration of the AEOLIX solution to local industry through the use of KPIs. FESTA methodology tailored to the needs of AEOLIX is proposed for the overall evaluation approach. The deliverable outlines the general evaluation framework for impact assessment of the AEOLIX solution and offers to the Living Lab partners the guidelines regarding the evaluation procedure to their respective Living Lab.
Electron tunneling spectroscopy study of electrically active traps in AlGaN/GaN high electron mobility transistors (2013)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Jie Yang, Sharon Cui, T. P. Ma, Ting-Hsiang Hung, Digbijoy Nath, Sriram Krishnamoorthy, Siddharth Rajan; Electron tunneling spectroscopy study of electrically active traps in AlGaN/GaN high electron mobility transistors. Appl. Phys. Lett. 25 November 2013; 103 (22): 223507. https://doi.org/10.1063/1.4834698 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioApplied Physics Letters Search Advanced Search |Citation Search
Polyoxometalates with Internal Cavities:  Redox Activity, Basicity, and Cation Encapsulation in [Xn+P5W30O110](15-n)- Preyssler Complexes, with X = Na+, Ca2+, Y3+, La3+, Ce3+, and Th4+ (2007)

The Preyssler anion, of general formula [Xn+P5W30O110](15-n)-, is the smallest polyoxometalate (POM) with an internal cavity allowing cation exchange with the solution. The Preyssler anion features a rich chemistry evidenced by its ability to accept electrons at low potentials, to selectively capture various metal cations, and to undergo acid-base reactions. A deep understanding of these topics is herein provided by means of DFT calculations on the title series of compounds. We evaluate the energetics of the release/encapsulation process for several Xn+ cations and identify the effect of the encapsulated ion on the properties of the Preyssler anion. We revisit the relationship between the internal cation charge and the electrochemical behavior of the POM. A linear dependence between the first one-electron reduction energies and the encapsulated Xn+ charge is found, with a slope of 48 mV per unit charge. The protonation also shifts the reduction potential to more positive values, but the effect is much larger. In connection to this, the last proton's pKa = 2 for the Na+ derivative was estimated to be in reasonable agreement with experiment. The electronic structure of lanthanide derivatives is more complex than conventional POM structures. The reduction energy for the CeIV-Preyssler + 1e- --> CeIII-Preyssler process was computed to be more exothermic than that of very oxidant species such as S2Mo18O624-.
<title>Excess noise in MWIR photovoltaic detectors fabricated using a new junction formation technology</title> (1999)

The current-voltage characteristics measured over a wide temperature range are reported for HgCdTe mid-wavelength IR n-on-p photodiodes fabricated using a novel junction formation technology. The planar homojunction device junctions were formed on LPE grown vacancy doped HgCdTe using a reactive ion etching (RIE) plasma induced conversion process. The zero bias dynamic resistance - junction area product, R<SUB>o</SUB>A, was 4.6 X 10<SUP>7</SUP> (Omega) .cm<SUP>2</SUP> at 80K an is comparable to the best planar diodes reported using conventional and significantly more complicated ion implantation junction formation technology. Arrhenius plots of R<SUB>o</SUB>A exhibit an activation energy equal to the bandgap, E<SUB>g</SUB>, and show that the diodes are diffusion limited for temperatures &gt;= 130K. In order to further compare this junction formation technology to other techniques, a series of temperature dependent 1/f noise measurements were performed. Form this study the activation energy for 1/f noise in the region where the diodes are diffusion limited was found to be 0.7E<SUB>g</SUB>. Energies close to this value have previously been associated with Hg vacancies in HgCdTe. These results are similar to those obtained from high quality HgCdTe photodiodes fabricated using mature ion implantation technology. However, the plasma based technology used in this work is significantly less complex and does not require any high temperature annealing steps.
Constrains of Super-Current Flow in YBCO Coated Conductors (2010)

High temperature superconducting YBa2Cu3O7 films have been prepared by pulsed laser deposition on top of single crystal substrates and metallic templates. Films have been investigated in order to determine the influence of microstructural peculiarities on the critical current density. It has been found that there is an inherent mechanism limiting the superconductive current flow in YBa2Cu3O7 film deposited on metallic template. This mechanism is associated with YBa2Cu3O7 film architecture, fabrication procedure and following low temperature usage.
The role of AI in prostate MRI quality and interpretation: Opportunities and challenges (2023)

Prostate MRI plays an important role in imaging the prostate gland and surrounding tissues, particularly in the diagnosis and management of prostate cancer. With the widespread adoption of multiparametric magnetic resonance imaging in recent years, the concerns surrounding the variability of imaging quality have garnered increased attention. Several factors contribute to the inconsistency of image quality, such as acquisition parameters, scanner differences and interobserver variabilities. While efforts have been made to standardize image acquisition and interpretation via the development of systems, such as PI-RADS and PI-QUAL, the scoring systems still depend on the subjective experience and acumen of humans. Artificial intelligence (AI) has been increasingly used in many applications, including medical imaging, due to its ability to automate tasks and lower human error rates. These advantages have the potential to standardize the tasks of image interpretation and quality control of prostate MRI. Despite its potential, thorough validation is required before the implementation of AI in clinical practice. In this article, we explore the opportunities and challenges of AI, with a focus on the interpretation and quality of prostate MRI.
Necrotizing myopathy induced by overexpression of interferon-? in transgenic mice (1999)

A transgenic mouse model has been established in which the cytokine interferon-gamma (IFN-gamma) is overexpressed through the action of the acetylcholine receptor epsilon promoter acting at the neuromuscular junction. While originally developed as a model for the study of the pathogenesis of myasthenia gravis, there are important differences from both human myasthenia gravis and its animal model, experimental autoimmune myasthenia gravis. By 4 months of age there was a well-established inflammatory, predominantly necrotizing myopathy, with marked dystrophic calcification. Dystrophic and degenerative changes in terminal axons and adjacent Schwann cells were also apparent. The acetylcholine receptor was not the primary target of the inflammatory response, since at 10 weeks of age the receptor content was not decreased and antibodies were not detected bound to the receptor. The IFNgamma transgenic mouse model may provide a clinically relevant model of necrotizing myopathy for investigation of the pathological changes associated with, and presumably precipitated by, overexpression of the pro-inflammatory cytokine interferon-gamma on the neuromuscular junction, intramuscular nerves and myofibers.
Designed, highly expressing, thermostable dengue virus 2 envelope protein dimers elicit quaternary epitope antibodies (2021)

Dengue virus (DENV) is a worldwide health burden, and a safe vaccine is needed. Neutralizing antibodies bind to quaternary epitopes on DENV envelope (E) protein homodimers. However, recombinantly expressed soluble E proteins are monomers under vaccination conditions and do not present these quaternary epitopes, partly explaining their limited success as vaccine antigens. Using molecular modeling, we found DENV2 E protein mutations that induce dimerization at low concentrations (<100 pM) and enhance production yield by more than 50-fold. Cross-dimer epitope antibodies bind to the stabilized dimers, and a crystal structure resembles the wild-type (WT) E protein bound to a dimer epitope antibody. Mice immunized with the stabilized dimers developed antibodies that bind to E dimers and not monomers and elicited higher levels of DENV2-neutralizing antibodies compared to mice immunized with WT E antigen. Our findings demonstrate the feasibility of using structure-based design to produce subunit vaccines for dengue and other flaviviruses.
Synthese mechatronischer Antriebe (2008)

Die Kapitel 11 und 12 geben Synthesemethoden unter dem Netzwerkaspekt einschließlich der Synthese von Schaltungen für vorgegebenes Bifurkationsverhalten wieder. Im Kapitel 20 sind zwei Synthesemethoden für elektromagnetische Felder zur systematischen Suche nach dem Feldstärkebzw. dem Potenzialverlauf unter Berücksichtigung der Randbedingungen vorgestellt. Wegen der im Allgemeinen existierenden Mehrdeutigkeit bei der Konstruktion einer Basis aus der über die Syntheseaufgabe gewonnenen Metrik (Feldaspekt) führen diese Methoden nur für ausgezeichnete Feldkonfigurationen zum Ziel. Spezielle geometrische Forderungen, die Berücksichtigung von Materialparametern und gewünschte Kraftverläufe innerhalb der synthetisierten Felder u. a. lassen sich nur bedingt berücksichtigen.
Powered wheelchairs and scooters for outdoor mobility: a pilot study on costs and benefits (2013)

The use of a PWC/S has been shown to positively affect a person's independence in daily activities which in turn increases the sense of self-esteem and security. Facilitating mobility is cost-effective both from a societal as well as from anindividual perspective and should be a key intervention in rehabilitation.
A novel approach for performance evaluation of OFDM with error correction coding and interleaving (1999)

A comparably simple method for the performance analysis of error correction coding including interleaving is applied to orthogonal frequency division multiplexing (OFDM). ATM cell oriented data transmission is considered. The method, previously proposed for hybrid simulation schemes (simulation of channel realizations followed by analytical performance prediction for the generated channels), is extended to a completely analytical one. The resulting technique is capable of yielding average bit and frame error rates, as well as outage probabilities. Rayleigh fading channels are investigated. The distribution of the wide-band average power of the frequency-selective channel is derived.
Toxicity and possible mechanisms of action of honokiol from Magnolia denudata seeds against four mosquito species (2019)

This study was performed to determine the toxicity and possible mechanism of the larvicidal action of honokiol, extracted from Magnolia denudata seeds, and its 10 related compounds against third-instar larvae of insecticide-susceptible Culex pipiens pallens, Aedes aegypti, and Aedes albopictus and Anopheles sinensis resistant to deltamethrin and temephos. Honokiol (LC<sub>50</sub>, 6.13-7.37 mg/L) was highly effective against larvae of all of the four mosquito species, although the toxicity of the compound was lower than that of the synthetic larvicide temephos. Structure-activity relationship analyses indicated that electron donor and/or bulky groups at the ortho or para positions of the phenol were required for toxicity. Honokiol moderately inhibited acetylcholinesterase and caused a considerable increase in cyclic AMP levels, indicating that it might act on both acetylcholinesterase and octopaminergic receptors. Microscopy analysis clearly indicated that honokiol was mainly targeted to the midgut epithelium and anal gills, resulting in variably dramatic degenerative responses of the midgut through sequential epithelial disorganization. Honokiol did not affect the AeCS1 mRNA expression level in Ae. aegypti larvae, but did enhance expression of the genes encoding vacuolar-type H<sup>+</sup>-ATPase and aquaporin 4, indicating that it may disturb the Na<sup>+</sup>, Cl<sup>-</sup> and K<sup>+</sup> co-transport systems. These results demonstrate that honokiol merits further study as a potential larvicide, with a specific target site, and as a lead molecule for the control of mosquito populations.
Introduction (2006)

If this sounds familiar to you, then you are the person for whom this book has been written. Continually displacing what is important for what is urgent is endemic amongst western managers. We call it the ‘fire-fighting syndrome’, because we have an image of a manager with a fire hose who spends his time fending off the problems of the day. The trouble is, of course, if we never make time for what we know to be important, we may not have a business tomorrow!
Preliminary results of real-time in-vitro electronic speckle pattern interferometry (ESPI) measurements in otolaryngology (1995)

Electronic Speckle Pattern Interferometry (ESPI) is a nondestructive optical evaluation technique that is capable of determining surface and subsurface integrity through the quantitative evaluation of static or vibratory motion. By utilizing state of the art developments in the areas of lasers, fiber optics and solid state detector technology, this technique has become applicable in medical research and diagnostics. Based on initial support from NIDCD and continued support from InterScience, Inc., we have been developing a range of instruments for improved diagnostic evaluation in otolaryngological applications based on the technique of ESPI. These compact fiber optic instruments are capable of making real time interferometric measurements of the target tissue. Ongoing development of image post- processing software is currently capable of extracting the desired quantitative results from the acquired interferometric images. The goal of the research is to develop a fully automated system in which the image processing and quantification will be performed in hardware in near real-time. Subsurface details of both the tympanic membrane and vocal cord dynamics could speed the diagnosis of otosclerosis, laryngeal tumors, and aid in the evaluation of surgical procedures.