gebhart/patrepeval huggingface dataset:
In Vivo Diffusion of Lidocaine through Tissue Expanders (1992)

It has been suggested that the addition of lidocaine to the saline used to fill tissue expanders will reduce the pain often associated with the expansion process. In vitro experiments have shown that lidocaine as it is normally supplied will diffuse through an expander only at a very slow rate, which would probably be inadequate for a clinical effect. We found that the addition of sodium bicarbonate resulted in a substantial increase in the rate of diffusion. Studies in rabbits demonstrated that at a pH of 8.0, 75 percent of the lidocaine dose crossed the silicone elastomer membrane at 24 hours and greater than 95 percent had left the expander at 1 week. We have concluded that intraluminal lidocaine can be effective only when the pH is close to the pKa of lidocaine.
Total Synthesis of (+)‐Haplophytine (2009)

Problem gelöst: Die Totalsynthese von Haplophytin (1) gelang durch eine konvergente Strategie mit modernsten Synthesemethoden. Schlüsselschritte sind eine durch hypervalentes Iod vermittelte oxidative Kupplung, eine oxidative Semipinakol-Umlagerung, eine Suzuki-Miyaura-Kupplung und eine radikalische Cyclisierung.
Ar depresijos klausimyne su nuovargiu susiję klausimai turi įtakos sąsajai su depresija ir nuovargiu sergantiesiems išemine širdies liga (2012)

Bibliogr.: p. 64
Protective Effect of KW-3635, a Specific Thromboxane A2-Receptor Antagonist, on Experimental Glomerulonephritis in Mice (1994)

We studied the effect of KW-3635, a selective thromboxane A2 (TXA2)-receptor antagonist, on experimental glomerulonephritis. The glomerulonephritis was induced in mice by the administration of rabbit anti-mouse glomerular basement membrane (GBM) antibody. It was characterized as proteinuria, changes of serum biochemical parameters and glomerular histopathological abnormalities. The administration of KW-3635 (30 mg/kg/day, p.o.) significantly ameliorated the proteinuria, elevation of serum urea nitrogen and the thickening of GBM. These data suggest that TXA2 may play an important pathogenic role in the development and progression of glomerulonephritis.
VIVO: a system for research discovery (2019)

vee-voh] is member-supported, enterprise open source software and an ontology for representing scholarship. VIVO supports recording, editing, searching, browsing and visualizing scholarly activity. VIVO encourages research discovery, expert finding, network analysis and assessment of research impact. VIVO is easily extended to support additional domains of scholarly activity (Brner, Conlon, Corson-Rikert, & Ying Ding, 2012).
Modeling and Control of Performance Expressin in Digital Waveguide Models of Woodwind Instruments (1996)

Most digital waveguide models of woodwind instruments to date have provided only basic control parameters such as frequency, breath pressure, and vibrato. It is clear that if these models are to gain popularity as real-time performance synthesizers or as composition tools, more flexibility is necessary. This paper discusses the implementation of expressive controls for flutter tonguing, growling, tone-bending, multiphonics, and variation of attack style. These eects are implemented on existing clarinet and flute waveguide instruments using the application SynthBuilder on a NeXTStep computer platform. Finally, control of these expressive eects using MIDI controllers is discussed.
Multimodal data fusion algorithm applied to robots (2020)

Abstract In recent years, the use of multimodal human-computer interaction technology to achieve the enhancement of human intelligence has become a new topic in human-computer interaction research. When the robot can’t react correctly in a single mode, it is necessary to realize multimodal fusion. To this end, this paper proposes a multimodal fusion algorithm that applies the data obtained by the CNN feature layer to the decision-level. The speech recognition text is semantically matched with the text in the text library, and the similar probability vector is returned. At the same time, the similarity probability vector of the gesture recognition is obtained, and the data is filtered by the threshold, and the set of high probability data codes is assigned to the two modes. The intersection operation, and the final instruction is sent to the robot. The experimental results show that the influence of environmental factors on the single channel result is reduced, and the single mode ambiguity problem is eliminated. The multi-channel fusion algorithm with additional weight is more accurate than the common multi-channel fusion algorithm. At the same time, it has also been well received by many test users.
Combining temporal interpolation and DCNN for faster recognition of micro-expressions in video sequences (2016)

Micro-expressions are the hidden human emotions that are short lived and are very hard to detect them in real time conversations. Micro-expressions recognition has proven to be an important behavior source for lie detection during crime interrogation. SMIC and CASME II are the two widely used, spontaneous micro-expressions datasets which are available publicly with baseline results that uses LBP-TOP for feature extraction. Estimation of correct parameters is the key factor for feature extraction using LBP-TOP, which results in long computation time. In this paper, the video sequences are interpolated using temporal interpolation(TIM) and then the facial features are extracted using deep convolutional neural network(DCNN) on CUDA enabled General Purpose Graphics Processing Unit(GPGPU) system. Results show that the proposed combination of DCNN and TIM can achieve better performance than the results published in baseline publications. The feature extraction time is reduced due to the usage of GPU enabled systems.
Enhanced usage of keys obtained by physical, unconditionally secure distributions (2014)

Unconditionally secure physical key distribution schemes are very slow, and it is practically impossible to use a one-time-pad based cipher to guarantee unconditional security for the encryption of data because using the key bits more than once gives out statistical information, for example via the known-plain-text-attack or by utilizing known components of the protocol and language statistics. Here we outline a protocol that reduces this speed problem and allows almost-one-time-pad based communication with an unconditionally secure physical key of finite length. The physical, unconditionally secure key is not used for data encryption but is employed in order to generate and share a new software-based key without any known-plain-text component. The software-only-based key distribution is then changed from computationally secure to unconditionally secure, because the communicated key-exchange data (algorithm parameters, one-way functions of random numbers, etc.) are encrypted in an unconditionally secure way with a one-time-pad. For practical applications, this combined physical/software key distribution based communication looks favorable compared to the software-only and physical-only key distribution based communication whenever the speed of the physical key distribution is much lower than that of the software-based key distribution. A mathematical security proof of this new scheme remains an open problem.
Multiplierless approximation of transforms with adder constraint (2002)

This letter describes an algorithm for systematically finding a multiplierless approximation of transforms by replacing floating-point multipliers with VLSI-friendly binary coefficients of the form k/2/sup n/. Assuming the cost of hardware binary shifters is negligible, the total number of binary adders employed to approximate the transform can be regarded as an index of complexity. Because the new algorithm is more systematic and faster than trial-and-error binary approximations with adder constraint, it is a much more efficient design tool. Furthermore, the algorithm is not limited to a specific transform; various approximations of the discrete cosine transform are presented as examples of its versatility.
Camera Model Anonymisation with Augmented cGANs (2020)

The model of camera that was used to capture a particular photographic image (model attribution) can be inferred from model-specific artefacts present within the image. Typically these artefacts are found in high-frequency pixel patterns, rather than image content. Model anonymisation is the process of transforming these artefacts such that the apparent capture model is changed. Improved methods for attribution and anonymisation are important for improving digital forensics, and understanding its limits. Through conditional adversarial training, we present an approach for learning these transformations. Significantly, we augment the objective with the losses from pre-trained auxiliary model attribution classifiers that constrain the generator to not only synthesise discriminative high-frequency artefacts, but also salient image-based artefacts lost during image content suppression. Quantitative comparisons against a recent representative approach demonstrate the efficacy of our framework in a non-interactive black-box setting.
Twin Rotor Damper for Human-Induced Vibrations of Footbridges (2020)

Footbridges often have a lightweight and slender design. As a result, they tend to be susceptible to human-induced vibrations. In this paper, the application of the twin rotor damper (TRD), an active mass damper consisting of two eccentrically rotating masses, for the control of human-induced footbridge vibrations is presented. A proof-of-concept prototype is developed for a real-world slender steel footbridge that is sensitive to human-induced vibrations. First, a numerical study is performed to design a TRD to mitigate human-induced vibrations. Based on these results, a TRD prototype was designed and built. Second, the performance of the TRD is evaluated on-site. The response of the footbridge to human-induced loading is measured under both uncontrolled and controlled conditions and compared to corresponding numerical simulations. The measurements confirm the results of the numerical simulations. They show that the TRD prototype is able to effectively damp human-induced vibrations of a real-world footbridge and validate the TRD design.
Production of oxidized lipids during modification of low-density lipoprotein by macrophages or copper (1994)

The oxidation of low-density lipoprotein (LDL) is implicated in atherosclerosis. Lipids and oxidized lipids were analysed by gas chromatography and gas chromatography-mass spectrometry in human LDL incubated with mouse peritoneal macrophages (MPM) or copper (II) sulphate in Ham's F-10 medium or medium alone (control). MPM-modification and copper-catalysed oxidation of LDL resulted in the formation of oxysterols, mainly cholest-5-en-3 beta,7 beta-diol (7 beta-OH-CHOL); 7%-19% of the initial cholesterol was converted to 7 beta-OH-CHOL in 24 h. 7 beta-OH-CHOL levels in control LDL were very low. The increase in 7 beta-OH-CHOL in MPM and copper-oxidized LDL was accompanied by decreases in linoleate and arachidonate and increases in the electrophoretic mobility and degradation of LDL protein by 'target' macrophages. The concerted occurrence of these processes and their similarity in both MPM-modification and copper-catalysed oxidation of LDL were suggested by the highly significant cross-correlations. The fall in polyunsaturated fatty acid (PUFA) was accompanied by a directly proportional increase in electrophoretic mobility of the LDL. Production of 7 beta-OH-CHOL and protein degradation by macrophages showed modest elevations during the initial steep fall in PUFA, and showed their greatest increases as the levels of PUFA slowly approached zero. The levels of 7 beta-OH-CHOL and the degradation of LDL by macrophages were directly proportional. The degradation of LDL by macrophages increased rapidly as the electrophoretic mobility of LDL was slowly approaching its maximum level.
Oxygen Excess Ratio Control of PEM Fuel Cell Based on Self-adaptive Fuzzy PID (2018)

Oxygen excess ratio is closely related to the output efficiency and service life of the proton exchange membrane (PEM) fuel cell system. To simulate dynamic behaviors of air flow, a fourth-order model of PEM fuel cell system is established. Then, a self-adaptive fuzzy PID (SFPID) controller is proposed to regulate the oxygen excess ratio on-line through its adaptive characteristic. Under different current disturbances, a comparison of proposed SFPID with several control topologies such as feedforward, PID, and PID plus feedforward (PID-FF) is carried out to validate the advantages of the proposed controller. Moreover, the proposed SFPID controller is applied to track the variable oxygen excess ratio. The simulation results display that the set-point value of oxygen excess ratio can be tracked rapidly and accurately, and verify that the proposed SFPID controller has good dynamic response performance.
Supplementary Figure 5 from Pattern of Invasion in Human Pancreatic Cancer Organoids Is Associated with Loss of SMAD4 and Clinical Outcome (2023)

&lt;p&gt;Association Between SMAD4 Status and Recurrence/Death&lt;/p&gt;
Mineralogy of the lunar crust: Results from Clementine (1999)

Abstract— The central peaks of 109 impact craters across the Moon are examined with Clementine ultraviolet‐visible (UVVIS) camera multispectral data. The craters range in diameter from 40 to 180 km and are believed to have exhumed material from 5–30 km beneath the surface to form the peaks, including both upper and lower crustal rocks depending on whether craters have impacted into highlands or basins. Representative five‐color spectra from spectrally and spatially distinct areas within the peaks are classified using spectral parameters, including “key ratio” (which is related to mafic mineral abundance) and “spectral curvature” (linked to absorption band shape, which distinguishes between low‐ and high‐Ca pyroxene and olivine). The spectral parameters are correlated to mineralogical abundances, related in turn to highland plutonic rock compositions. The derived rock compositions for the various central peaks are presented in a global map. From these results, it is evident that the lunar crust is compositionally diverse, both globally and at local 100 m scales found within individual sets of central peaks. Although the central peaks compositions imply a crust that is generally consistent with previous models of crustal structure, they also indicate a more anorthositic crust than generally assumed, with a bulk plagioclase content of ∼81%, evolving from “pure” anorthosite near the surface towards more mafic, low‐Ca pyroxene‐rich compositions with depth (comparable to anorthositic norite). Evidence for mafic plutons occurs in both highlands and basins and represent all mafic highland rock types. However, the lower crust is more compositionally diverse than the highlands, with both a greater range of rock types and more diversity within individual sets of central peaks.
p53 tumor-suppressor gene: Clues to molecular carcinogenesis (1997)

The tumor-suppressor gene product p53 is clearly a component in several biochemical pathways, including transcription, DNA repair, genomic stability, cell-cycle control and apoptosis, that are central to human carcinogenesis. The p53 is functionally inactivated by mutational, viral, and cellular mechanisms in the majority of human cancers. Analysis of the spectrum of p53 mutations provides clues to the etiology and molecular pathogenesis of cancer. Recent insight into the p53-mediated biochemical pathways of cell-cycle arrest and apoptosis has provided further understanding of the mechanisms related to p53-mediated tumor suppression. This insight in turn may provide the potential molecular targets for the development of rational multimodality cancer therapy, including chemo-, immuno-, and gene-therapeutic strategies. The convergence of previously parallel lines of basic, clinical, and epidemiologic investigation may provide an opportunity to transfer research findings rapidly from the laboratory to the clinic.
The syndrome of inappropriate antidiuretic hormone secretion associated with induction chemotherapy for squamous cell carcinoma of the head and neck (1986)

Two patients with squamous cell carcinoma of the head and neck are reported in whom the syndrome of inappropriate antidiuretic hormone (SIADH) secretion occurred transiently during the rapid cytolytic phase of tumor destruction after chemotherapy with cis-platinum diamminedichloride and bleomycin. Immunoperoxidase staining for ADH of the original biopsy specimens from both patients was negative. Possible mechanisms for and the implications of the production of SIADH in this setting are discussed.
The role of Sufentanil in intensive care unit (2023)

Dear Editor, The problem of analgosedation in Intensive Care Units is as old as the Intensive Care Unit itself, but it is only in recent years that the importance of the "fifth vital parameter" in terms of association has been recognized not only as immediate complications such as agitation and delirium but also in the long term with post-traumatic stress disorder, chronic pain, and reduced quality of life after discharge, so much so as to recognize the need to adopt pain and agitation control scales even in non-communicating patients or patients with altered mental status.1[...]
Beschluss der STIKO zur 5. Aktualisierung der COVID-19-Impfempfehlung und die dazugehörige wissenschaftliche Begründung (2021)

Die STIKO empfiehlt die Impfung gegen COVID-19 mit einem der beiden zugelassenen mRNA-Impfstoffe (Comirnaty von BioNTech/Pfizer, COVID-19-Vaccine von Moderna) oder einem der beiden zugelassenen Vektor-basierten Impfstoffe (Vaxzevria von AstraZeneca, COVID-19 Vaccine Janssen von Janssen-Cilag International). Wie im Epidemiologischen Bulletin 19/2021 ausgeführt, werden die Impfstoffe hinsichtlich des Individualschutzes und der Bekämpfung der Pandemie als gleich geeignet beurteilt. Die beiden mRNA-Impfstoffe können in allen Alters- und Indikationsgruppen eingesetzt werden, für die sie zugelassen sind. Auf Basis der derzeit verfügbaren, allerdings noch begrenzten Evidenz und unter Berücksichtigung der gegenwärtigen pandemischen Lage empfiehlt die STIKO, Vaxzevria und COVID-19 Vaccine Janssen für Personen im Alter ≥60 Jahren zu verwenden. Der Einsatz von Vaxzevria für eine 1. oder 2. Impfstoffdosis und der COVID-19 Vaccine Janssen als einmalige Impfung unterhalb dieser Altersgrenze bleibt indes nach ärztlicher Aufklärung und bei individueller Risikoakzeptanz durch die impfwillige Person möglich.
MRI-guided focused ultrasound ablation of lumbar medial branch nerve: Feasibility and safety study in a swine model (2016)

Histological analysis of the in vivo studies confirmed thermal necrosis of the MB nerve could be achieved without damaging the spinal cord or adjacent nerve roots. MRgFUS did not cause changes in the animals' behaviour or ambulation.
An acoustic simulation approach for testing ADCP (2013)

The difficulty of calibrating ADCPs has long been known. This paper describes an acoustic simulation approach to accomplish the functional and accurate calibration of ADCP. By the acoustic approach, the simulation system monitors the ADCP transmitted pulse, simulates the actual backscatter signal that an ADCP would receive, provides wide scope of profiling range and current velocity simulation, thereby allow direct calibration. Application of the simulation system in functional and accurate calibrations and addressing system failures is also introduced.
Evidence for impaired amyloid β clearance in Alzheimer's disease (2013)

Alzheimer's disease (AD) is a common neurodegenerative disease characterized by the accumulation of extracellular plaques and intracellular tangles. Recent studies support the hypothesis that the accumulation of amyloid beta (Aβ) peptide within the brain arises from an imbalance of the production and clearance of Aβ. In rare genetic forms of AD, this imbalance is often caused by increased production of Aβ. However, recent evidence indicates that, in the majority of cases of AD, Aβ clearance is impaired. Apolipoprotein E (ApoE), the dominant cholesterol and lipid carrier in the brain, is critical for Aβ catabolism. The isoform of ApoE and its degree of lipidation critically regulate the efficiency of Aβ clearance. Studies in preclinical models of AD have demonstrated that coordinately increasing levels of ApoE and its lipid transporter, ABCA1, increases the clearance of Aβ, suggesting that this pathway may be a potential therapeutic target for AD.
Control of Jet Mixing and Supersonic Jet Noise by Resonance Effects in Wake Shedding from Parallel Plates (1995)

The objective of this study was to evaluate the effects of splitter plates mounted longitudinally parallel to the centerline of a single rectangular nozzle on nozzle noise performance as a function of jet Mach number and lip thickness. A pair of splitter plates were mounted at the exit of a convergent rectangular nozzle. In addition to making farfield noise measurements in an anechoic chamber, the mixing characteristics of this arrangement were evaluated qualitatively through flow visualization. It was found that such an arrangement enhanced the mixing of the jet considerably and reduced the noise of the jet at supersonic conditions by as much as 10 dB at most polar angles. Thicker inserts produced larger reductions in noise. The noise reduction appeared to occur as a result of vigorous jet mixing produced by the vortex shedding introduced by the splitter inserts. The mixing appeared to be most prominent whenever there existed some form of vibration of the splitter plates. Substantial noise reductions were obtained on using an ejector in conjunction with the inserts. High intensity tones associated with the vortex shedding in the wake of the splitter plates were observed at the subsonic conditions. Broadband noise also increased significantly at the subsonic conditions. In fact, at certain subsonic conditions, Parkers resonance took place with such high levels that the splitter plates underwent serious structural failures.
[A case of epithelioid hemangioendothelioma of the liver: detection by FDG-PET]. (2009)

A 57 year-old woman was admitted for focal accumulation of 18F-fluorodeoxyglucose (FDG) in the liver detected by positron emission tomography (PET). A 25- mm hypovascular tumor was detected by computed tomography. Tumor biopsy revealed many atypical cells with positive staining for factor VIII-related-antigen in sinusoids. Right lobectomy was performed and the tumor was diagnosed as epithelioid hemangioendothelioma (EHE) pathologically. We demonstrated that FDG-PET was useful for the diagnosis of EHE and making deciding on therapeutic strategy.