gebhart/patrepeval huggingface dataset:
Spectral Images and Features Co-Clustering with Application to Content-based Image Retrieval (2005)

In this paper, we present a spectral graph partitioning method for the co-clustering of images and features. We present experimental results, which show that spectral co-clustering has computational advantages over traditional k-means algorithm, especially when the dimensionalities of feature vectors are high. In the context of image clustering, we also show that spectral co-clustering gives better performances. We advocate that the images and features co-clustering framework offers new opportunities for developing advanced image database management technology and illustrate a possible scheme for exploiting the co-clustering results for developing a novel content-based image retrieval method
Inflammatory Biomarkers in Combat Wound Healing (2009)

The cytokine and chemokine protein and gene transcript expression patterns demonstrate a condition of inflammatory dysregulation associated with war wound failure. A molecular biomarker panel may predict combat wound healing outcome and warrants prospective validation.
Tumor Necrosis Factor Inhibitor Dose Reduction for Axial Spondyloarthritis: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials (2020)

Patients with axial SpA may experience little to no clinical benefit from reduction of TNFi therapy. Maintaining the standard dose probably improves the sustained effect on disease activity and helps to prevent disease flare.
High‐dose alcohol intoxication differentially modulates cognitive subprocesses involved in response inhibition (2014)

Aside from well-known physiological effects, high-dose alcohol intoxication (a.k.a. binge drinking) can lead to aversive social and legal consequences because response inhibition is usually compromised under the influence of alcohol. Although the behavioral aspects of this phenomenon were reported on extensively, the underlying neurophysiological mechanisms mediating this disinhibition are unclear. To close this gap, we used both behavioral and neurophysiological measures (event-related potentials, ERPs) to investigate which subprocesses of response inhibition are altered under the influence of high-dose alcohol intoxication. Using a within-subject design, we asked young healthy participants (n = 27) to complete a GO/NOGO task once sober and once intoxicated (approximately 1.2‰). During intoxication, high-dose alcohol effects were highest in a condition where the participants could not rely on automated stimulus-response mapping processes during response inhibition. In this context, the NOGO-P3 (ERP), that likely depends on dopaminergic signaling within mesocorticolimbic pathways and is thought to reflect motor inhibition and/or the evaluation of inhibitory processes, was altered in the intoxicated state. In contrast to this, the N2 component, which largely depends on nigrostriatal dopamine pathways and is thought to reflect inhibition on a pre-motor level, was not altered. Based on these results, we demonstrate that alcohol-induced changes of dopaminergic neurotransmission do not exert a global effect on response inhibition. Instead, changes are highly subprocess-specific and seem to mainly target mesocorticolimbic pathways that contribute to motor inhibition and the evaluation of such.
Identification of Brassinolide, Castasterone and Norcastasterone (Brassinone) in Sunflower(Helianthus annumL.) Pollen (1989)

Journal Article Identification of Brassinolide, Castasterone and Norcastasterone (Brassinone) in Sunflower (Helianthus annum L.) Pollen Get access Suguru Takatsuto, Suguru Takatsuto Department of Chemistry, Joetsu University of Education, Joetsu-shi, Niigata 943, Japan To whom correspondence should be addressed. Search for other works by this author on: Oxford Academic Google Scholar Takao Yokota, Takao Yokota Department of Agricultural Chemistry, The University of Tokyo, Bunkyo-ku, Tokyo 113, Japan Search for other works by this author on: Oxford Academic Google Scholar Kumiko Omote, Kumiko Omote Department of Chemistry, Joetsu University of Education, Joetsu-shi, Niigata 943, Japan Search for other works by this author on: Oxford Academic Google Scholar Keiji Gamoh, Keiji Gamoh Faculty of Education, Kochi University, Akebonocho, Kochi-shi 780, Japan Search for other works by this author on: Oxford Academic Google Scholar Nobutaka Takahashi Nobutaka Takahashi Department of Agricultural Chemistry, The University of Tokyo, Bunkyo-ku, Tokyo 113, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 53, Issue 8, 1 August 1989, Pages 2177–2180, https://doi.org/10.1080/00021369.1989.10869607 Published: 01 August 1989 Article history Received: 03 March 1989 Published: 01 August 1989
Detecting Pulse from Head Motions in Video (2013)

We extract heart rate and beat lengths from videos by measuring subtle head motion caused by the Newtonian reaction to the influx of blood at each beat. Our method tracks features on the head and performs principal component analysis (PCA) to decompose their trajectories into a set of component motions. It then chooses the component that best corresponds to heartbeats based on its temporal frequency spectrum. Finally, we analyze the motion projected to this component and identify peaks of the trajectories, which correspond to heartbeats. When evaluated on 18 subjects, our approach reported heart rates nearly identical to an electrocardiogram device. Additionally we were able to capture clinically relevant information about heart rate variability.
Analysing training needs of TVET teachers in South Africa: An empirical study (2019)

Context: This paper reports on a study of the progress of vocational education and training (VET) and the need for further profession-oriented training of lecturers in public, technical vocational colleges in South Africa, under the consideration of societal and political conditions.Approach: The study is based on a mixed methods approach in which an analysis of educational policy documents and a qualitative and a quantitative study with VET teachers and representatives of education authorities in South Africa are conducted.Findings: The classification of the results is conducted in line with the conditions defined by Phillips and Ochs regarding policy transfers. The following can thus be observed through the bilateral relationship between Germany and South Africa: (1) The Guiding Philosophy of the educational system is characterised by societal and political power structures. This is evident in an analysis of approved reforms within the last two decades. (2) The desired effects of “Ambitions Goals” have thus far not taken hold. Nonetheless, there is a willingness to enact reforms to continue developing vocational education, including the training and further education of lecturers that must be noted. Minimum requirements regarding lecturers’ basic qualifications have been formulated, which one in five vocational lecturers in South Africa currently cannot fulfil. (3) The Strategies formulated to implement training methods face the main problem of difficulty in implementation in colleges. (4) The Enabling Structures, i.e. the education-management-system as well as the financial and personnel support of the educational system, are widely perceived by lecturers as unsupportive, ineffective and discriminatory. This is observed, for example, when looking at the equipment used, teachers’ salaries, classroom sizes as well as the mentorship programme and further training opportunities. (5) Processes: a discrepancy exists on the level of the lecturers and the central need for further training regarding modern technologies, especially those used by foreign firms in their production in South Africa. (6) The results of the conducted study document a high variation of qualifications among TVET lecturers when it examines their teaching Techniques.Conclusions: Overall, the empirical results of the study reveal a complex structure with respect to the requirements for further training of TVET lecturers, describe central needs for further training of lecturers and deliver connectable knowledge for both the practical educational advancement of lecturer training and further education training, as well as for research in the context of the internationalisation of vocational training in South Africa.
Infrared to vacuum-ultraviolet ellipsometry and optical Hall-effect study of free-charge carrier parameters in Mg-doped InN (2013)

Infrared to vacuum-ultraviolet spectroscopic ellipsometry and far-infrared optical Hall-effect measurements are applied to conclude on successful p-type doping of InN films. A representative set of In-polar Mg-doped InN films with Mg concentrations ranging from 1.2×1016 cm−3 to 3.9×1021 cm−3 is investigated. The data are compared and discussed in dependence of the Mg concentration. Differences between n-type and p-type conducting samples are identified and explained. p-type conductivity in the Mg concentration range between 1.1×1018 cm−3 and 2.9×1019 cm−3 is indicated by the appearance of a dip structure in the infrared spectral region related to a loss in reflectivity of p-polarized light as a consequence of reduced LO phonon plasmon coupling, by vanishing free-charge carrier induced birefringence in the optical Hall-effect measurements, and by a sudden change in phonon-plasmon broadening behavior despite continuous change in the Mg concentration. By modeling the near-infrared-to-vacuum-ultraviolet ellipsometry data, information about layer thickness, electronic interband transitions, as well as surface roughness is extracted in dependence of the Mg concentration. A parameterized model that accounts for the phonon-plasmon coupling is applied for the infrared spectral range to determine the free-charge carrier concentration and mobility parameters in the doped bulk InN layer as well as the GaN template and undoped InN buffer layer. The optical Hall-effect best-match model parameters are consistent with those obtained from infrared ellipsometry analysis.
ChemInform Abstract: FLUORINATIONS WITH POTASSIUM TETRAFLUOROCOBALTATE(III) PART 5, THE FLUORINATIONS OF SOME POLYCYCLIC AROMATIC HYDROCARBONS OVER POTASSIUM TETRAFLUOROCOBALTATE(III) AND AN IMPROVED SYNTHESIS OF PERFLUORO‐PHENANTHRENE AND ‐PYRENE (1974)

Abstract Bei der Fluorierung von Anthracen, Phenanthren, Decafluorphenanthren und Biphenyl über KCoF 4 (in einigen Fällen über CsCoF 4 ) entstehen Produktgemische aus im wesentlichen olefinischen und aromatischen perfluorierten Ringsystemen.
Sensory Deficits and Distributed Hierarchical Dysfunction in Schizophrenia (2010)

These findings confirm and extend previous reports of impaired basic sensory processing in schizophrenia and demonstrate significant contributions of early sensory processing dysfunction to higher-order cognitive impairments. Overall, the findings support distributed, hierarchical models of cognitive impairment in schizophrenia, consistent with glutamatergic and other widespread neurochemical models of the disorder.
ChemInform Abstract: Synthesis of Polysubstituted Benzenes from 2‐Pyrone‐4,6‐dicarboxylic Acid. (2015)

Abstract The thermal decarboxylative cycloaddition of the title compound and its dimethyl ester with vinyl acetates (I) and (IV) or alkynyls (IX) and (XI) follows Diels‐Alder methodology.
Mechanisms of circular defects for shallow trench isolation oxide deposition (2003)

Shallow trench isolation (STI) is extensively used as the isolation method beyond 0.18 μm generation. This study explored the formation of circular defects in high-density plasma (HDP) STI deposition. Circular defects were caused by the burst flow of silane reactive gas. The defect maps were coincident with the silane flow field. Fourier transform infrared and secondary-ion-mass spectroscopy data exhibited that the silane-burst flow formed a silicon rich oxide (SRO) film. This SRO film existed between the STI oxide and liner oxide. The circular defects were easily found using optical microscopy (OM) for STI with SRO film. Scanning electron microscopy and transmission electron microscopy photographs show that these defects include bubbles and concavities. When SRO fully covers the liner oxide, bubbles easily form by delamination between SRO film and liner oxide. This correlates with the high tensile stress produced by the SRO film. Besides this, higher STI deposition temperatures yield more bubbles. When SRO discontinuously forms on the liner oxide, the concavities were induced by the variation of STI deposition rate on SRO film and liner oxide. The surface charge difference between the SRO film and the liner oxide is the driving force for the generation of concavities.
Studies on the humoral immune response to a synthetic vaccine against Plasmodium falciparum malaria (1991)

A synthetic vaccine against the asexual blood stages of P. falciparum, the SPf 66 synthetic hybrid polymer, composed of peptides derived from three merozoite membrane proteins as well as one peptide from the sporozoite CS protein, has been developed by our group and tested in different protection assays in Aotus monkeys as well as in human volunteers. This study evaluates the humoral immune response induced by the SPf 66 protein vaccination in adult human volunteers from the Colombian Pacific coast as follows: determination of specific IgG antibody levels against SPf 66 by FAST-ELISA after each immunization; analysis of antibody reactivity with P. falciparum schizont lysates by immunoblots; and determination of the in vitro parasite growth inhibition. A clear boosting effect, dependent on time and dose, was observed in the antibody production kinetics. These antibodies also specifically recognize three proteins of the P. falciparum schizont lysate corresponding to the molecular weights of the proteins from which the amino acid sequence was derived. These sera were also capable of markedly inhibiting in vitro parasite growth.
Genome Characterization and Potential Risk Assessment of the Novel SARS-CoV-2 Variant Omicron (B.1.1.529) (2021)

As the novel coronavirus SARS-CoV-2 spread around the world, multiple waves of variants emerged, thus leading to local or global population shifts during the pandemic. A new variant named Omicron (PANGO lineage B.1.1.529), which was first discovered in southern Africa, has recently been proposed by the World Health Organization to be a Variant of Concern. This variant carries an unusually large number of mutations, particularly on the spike protein and receptor binding domain, in contrast to other known major variants. Some mutation sites are associated with enhanced viral transmission, infectivity, and pathogenicity, thus enabling the virus to evade the immune protective barrier. Given that the emergence of the Omicron variant was accompanied by a sharp increase in infection cases in South Africa, the variant has the potential to trigger a new global epidemic peak. Therefore, continual attention and a rapid response are required to decrease the possible risks to public health.
Uncovering novel mobile genetic elements and their dynamics through an extra-chromosomal sequencing approach (2016)

Staphylococcus aureus is a major clinically important pathogen with well-studied phage contributions to its virulence potential. In this commentary, we describe our method to enrich and sequence stealth extra-chromosomal DNA elements in the bacterial cell, allowing the identification of novel extra-chromosomal prophages in S. aureus clinical strains. Extra-chromosomal sequencing is a useful and broadly applicable tool to study bacterial genomics, giving a temporal glance at the extra-chromosomal compartment of the cell and allowing researchers to uncover lower-copy plasmidial elements (e.g., prophages) as well as gain a greater understanding of mobile genetic elements that shuffle on and off the chromosome. Here, we describe how episomal and plasmidial DNA elements can have profound downstream effects on the host cell and surrounding bacterial population, and discuss specific examples of their importance in Gram-positive bacteria. We also offer potential avenues of future research where extra-chromosomal sequencing may play a key role in our understanding of the complete virulence potential of infectious bacteria.
Nuclear Factor Erythroid 2-Related Factor 2 in Regulating Cancer Metabolism (2020)

<b><i>Significance:</i></b> Nuclear factor erythroid 2 (NFE2)-related factor 2 (<i>NFE2L2</i>, or NRF2) is a transcription factor predominantly affecting the expression of antioxidant genes. NRF2 plays a significant role in the control of redox balance, which is crucial in cancer cells. NRF2 activation regulates numerous cancer hallmarks, including metabolism, cancer stem cell characteristics, tumor aggressiveness, invasion, and metastasis formation. We review the molecular characteristics of the NRF2 pathway and discuss its interactions with the cancer hallmarks previously listed. <b><i>Recent Advances:</i></b> The noncanonical activation of NRF2 was recently discovered, and members of this pathway are involved in carcinogenesis. Further, cancer-related changes (<i>e.g.</i>, metabolic flexibility) that support cancer progression were found to be redox- and NRF2 dependent. <b><i>Critical Issues:</i></b> NRF2 undergoes Janus-faced behavior in cancers. The pro- or antineoplastic effects of NRF2 are context dependent and essentially based on the specific molecular characteristics of the cancer in question. Therefore, systematic investigation of NRF2 signaling is necessary to clarify its role in cancer etiology. The biggest challenge in the NRF2 field is to determine which cancers can be targeted for better clinical outcomes. Further, large-scale genomic and transcriptomic studies are missing to correlate the clinical outcome with the activity of the NRF2 system. <b><i>Future Directions:</i></b> To exploit NRF2 in a clinical setting in the future, the druggable members of the NRF2 pathway should be identified. In addition, it will be important to study how the modulation of the NRF2 system interferes with cytostatic drugs and their combinations.
Polymers from bio-derived dicarboxylic acids (2023)

The present disclosure relates to a polymer that includes a first repeat unit having the structure where m is between 1 and 1,000, R1 includes a first organic group, and R2 includes a second organic group.
Effect of Overexpression of PDAT Gene on Arabidopsis Growth Rate and Seed Oil Content (2014)

Arabidopsis (ecotype Columbia 0) plants was transformed with AtPDAT (phospholipid: diacylglycerol acyltransferase) gene behind the cauliflower mosaic virus 35S promoter. Transformed plants were selected by exposure to kanamycin and further grown on peat-based soil media in growth chamber. The seeds of T1 plants (T2 seeds) segregated and containing homozygotes, heterozygotes and null segregants (without transgene). The T3 seeds of selected null segregants and transformed homozygotes were further grown on peat-based soil media in growth chamber (T3 plants) and the lipid content in their seeds (T4 seeds) were evaluated. Additionally T4 seeds of selected null segregants and selected transformed plants (homozygotes) were used for evaluation of AtPDAT overexpression effect on seedlings growth rate, measurement of PDAT activity and for greenhouse experiments. Results show that PDAT overexpression increased the growth rate of Arabidopsis plants. This phenomenon was observed both during germination and further growth of the seedlings on agar plate as well as during the germination and further growth of the plant on peat-based soil media during the greenhouse experiment. The positive effect on oil production in transformed plants was also observed, however, it was probably not directly attributable to PDAT action but rather an indirect cause of growth stimulation.
A Comparison of the Relative Effects of Obesity and Non-insulin-dependent Diabetes Mellitus on In Vivo Insulin-stimulated Glucose Utilization (1984)

Insulin clamp studies were carried out in 50 individuals, 25 with normal glucose tolerance and 25 with non-insulin-dependent diabetes mellitus (NIDDM). Both diagnostic groups were further subdivided on the basis of body mass index (BMI) into an obese (BMI greater than 28 kg/m2) or nonobese group (BMI less than 28 kg/m2). The obese and nonobese subjects in each diagnostic category had similar plasma glucose levels in response to an oral glucose challenge. In addition, insulin-stimulated glucose utilization, as assessed by determination of glucose metabolic clearance rate (MCR), was not different as a function of obesity. Glucose MCR (mean +/- SEM) in obese subjects (mean BMI = 32.1) with normal glucose tolerance was 162 ml/min/m2, as compared with a value of 205 ml/min/m2 in nonobese individuals (mean BMI = 23.8). This difference was not statistically significant. Similarly, glucose MCR in obese patients (mean BMI = 34.7) with NIDDM was 55 ml/min/m2, as compared with a value of 80 ml/min/m2 in nonobese subjects (mean BMI = 24.9) with NIDDM. However, as can be seen from the above data, glucose MCR in patients with NIDDM, either nonobese or obese, was markedly reduced (P less than 0.001) when compared with that of normal subjects. These data emphasize the profound effect of NIDDM on reducing in vivo insulin action, and point out that the impact of obesity on insulin resistance is minor in comparison.
A Novel Vector-Based Computer Tomography Alignment Measurement Protocol for Total Knee Arthroplasty. (2020)

Component position and overall limb alignment following total knee arthroplasty (TKA) have been shown to influence implant survivorships and clinical outcomes. While most surgeons utilize standard x-ray imaging for preoperative joint assessments, computer tomography scans (CT), coupled with automated digital analyses have been shown to provide additional surgical and clinical benefits. However, to date, a postoperative CT measurement protocol has not been reported for robotic-arm assisted TKA (RATKA). Therefore, the purpose of this paper was to assess the validity of a novel, vector-based CT alignment measurement protocol. Specifically, we compared: 1) final versus planned component alignment and placement; 2) inter-observer reliability; and 3) intra-observer reliability.The CT-based technique utilized mathematical models to calculate prosthetic alignments from anatomical landmarks. To assess the models, 30 CT scans from multiple centers were collected on RATKA patients at six weeks postoperatively and analyzed using the proposed technique. Results were compared to the surgeons' preoperative plans for accuracy. Analyses were performed on the same protocol to determine inter-observer reliability. These analyses were repeated 30 days later to assess for intra-observer variability.The mean measurement errors compared between final versus planned component positions and alignments were: 0.79±1.48o varus in overall limb alignment (p=0.004); 0.34±1.20o varus (p=0.121); and 0.35±1.15o varus (p=0.17) for femoral and tibial varus/valgus alignment; 0.71±1.77o flexion (p=0.18) and 0.38±1.88o posterior (p=0.41) for femoral flexion and tibial slope. There was strong reproducibility between observers. Correlation analyses showed low variabilities, with slopes between 0.8 to 1.0 and all R>0.8.As robotic technologies become widely available in orthopaedic surgery, it is critical to have tools, such as CT protocols, which can quantitatively verify operative decisions concerning limb alignment and component placement. This study described a novel, vector-based, CT alignment measurement protocol for RATKA which has not previously been defined. The method demonstrated excellent accuracy to plan and low intra- and inter-observer variability. This is a valuable analysis tool for RATKA studies where component accuracy is assessed using postoperative CT images.
Finitness Principles for Smooth Selection (2016)

In this paper we prove finiteness principles for $C^{m}\left( \mathbb{R}^{n}, \mathbb{R}^{D}\right) $-selection, and for $C^{m-1,1}\left( \mathbb{R}^{n}, \mathbb{R}^{D}\right) $-selection, in particular providing a proof for a conjecture of Brudyni-Shvartsman (1994) on Lipschitz selections for the case when the domain is $X = \mathbb{R}^n$.