gebhart/patrepeval huggingface dataset:
TREAT experimental data base regarding fuel dispersals in LMFBR loss-of-flow accidents (1981)

The reactivity feedback from fuel relocation is a central issue in the analysis of loss-of-flow (LOF) accidents in LMFBRs. Fuel relocation has been studied in a number of LOF simulations in the TREAT reactor. In this paper the results of these tests are analyzed, using, as the principal figure of merit, the changes in equivalent fuel worth associated with the fuel motion. The equivalent fuel worth was calculated from the measured axial fuel distributions by weighting the data with a typical LMFBR fuel-worth function. At nominal power, the initial fuel relocation resulted in increases in equivalent fuel worth. Above nominal power the fuel motion was dispersive, but the dispersive driving forces could not unequivocally be identified from the experimental data.
Adjuvants Influence the Immunoglobin Subclass Distribution of Immune Responses in Vivo (1984)

Mice were immunized against fluorescein isothiocyanate (FITC)-labelled human gamma globulin (HGG) in the absence or presence of different adjuvants. The immune response was assayed every other day with regard to both total Ig-secreting cells and FITC-specific plaque-forming cells (PFC). The adjuvants influenced the type of immune response induced to the same antigenic determinant. Thus, addition of Freund's complete (FCA) or incomplete (FIA) adjuvant preferentially led to the secretion of IgG1 PFC of an average high affinity. Most newly appearing IgG-secreting cells were also detected as FITC-specific PFC. The use of lipopolysaccharide (LPS) as an adjuvant resulted in the induction of both IgM and IgG, particularly of the IgG3 and IgG2b subclasses. However, these antibodies had relatively low affinity, and a large number of total IgG-secreting cells induced by LPS had no detectable FITC specificity. The FCA/FIA- and LPS-induced responses to FITC-HGG were additive when injected together, indicating that they act on distinct subpopulations of B lymphoid cells. The adjuvant response to LPS, but not the response to FCA/FIA, was totally absent in mice of the C3H/Hej strain, which are non-responders to the polyclonal activating properties of LPS. Finally, the response induced by FCA or FIA was T-cell-dependent and the LPS response T-cell-independent as assayed in nude mice.
Multiresolution image registration for two-dimensional gel electrophoresis (2001)

In proteomic research, two-dimensional electrophoresis (2-D) is an important tool for investigating differential patterns of qualitative and quantitative protein expression. The strength of the technique is due to its unrivalled power of being able to separate simultaneously thousands of proteins. The key to the comparison of 2-D protein profiles, however, lies in the use of a fast and robust image matching process which is essential to the subsequent quantification procedure. To satisfy the growing demand for a robust and fully automatic method of matching 2-D gel protein separation profiles, we describe in this paper a novel registration technique based on image intensity distribution rather than selected features. The method uses a multiresolution representation of the gel profiles and exploits the fact that coarse approximations to the optimal matching can be extracted efficiently from low-resolution images. This permits the removal of misalignments at different scales in a systematic manner and the strength of the new method has been confirmed by a double blind trial of 111 2-D gel pairs. The proposed method requires neither landmarks nor an a priori image alignment, and takes about five seconds for processing a typical gel pair on a standard personal computer.
A functional assay for the clinical annotation of genetic variants of uncertain significance in Diamond-Blackfan anemia (2018)

Diamond-Blackfan anemia (DBA) is a rare genetic hypoplasia of erythroid progenitors characterized by mild to severe anemia and associated with congenital malformations. Clinical manifestations in DBA patients are quite variable and genetic testing has become a critical factor in establishing a diagnosis of DBA. The majority of DBA cases are due to heterozygous loss-of-function mutations in ribosomal protein (RP) genes. Causative mutations are fairly straightforward to identify in the case of large deletions and frameshift and nonsense mutations found early in a protein coding sequence, but diagnosis becomes more challenging in the case of missense mutations and small in-frame indels. Our group recently characterized the phenotype of lymphoblastoid cell lines established from DBA patients with pathogenic lesions in RPS19 and observed that defective pre-rRNA processing, a hallmark of the disease, was rescued by lentiviral vectors expressing wild-type RPS19. Here, we use this complementation assay to determine whether RPS19 variants of unknown significance are capable of rescuing pre-rRNA processing defects in these lymphoblastoid cells as a means of assessing the effects of these sequence changes on the function of the RPS19 protein. This approach will be useful in differentiating pathogenic mutations from benign polymorphisms in identifying causative genes in DBA patients.
Carboxylation of Kinetically Inert Platinum(IV) Hydroxy Complexes. An Entr.acte.ee into Orally Active Platinum(IV) Antitumor Agents (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarboxylation of Kinetically Inert Platinum(IV) Hydroxy Complexes. An Entr.acte.ee into Orally Active Platinum(IV) Antitumor AgentsChristen M. Giandomenico, Michael J. Abrams, Barry A. Murrer, Jean F. Vollano, Melanie I. Rheinheimer, Sandra B. Wyer, Gerald E. Bossard, and John D. HigginsCite this: Inorg. Chem. 1995, 34, 5, 1015–1021Publication Date (Print):March 1, 1995Publication History Published online1 May 2002Published inissue 1 March 1995https://pubs.acs.org/doi/10.1021/ic00109a004https://doi.org/10.1021/ic00109a004research-articleACS PublicationsRequest reuse permissionsArticle Views2659Altmetric-Citations223LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Osteogenesis of adipose-derived stem cells on polycaprolactone-β-tricalcium phosphate scaffold fabricated via selective laser sintering and surface coating with collagen type I (2013)

The current study aimed to fabricate three-dimensional (3D) polycaprolactone (PCL), polycaprolactone and β-tricalcium phosphate (PCL-TCP) scaffolds via a selective laser-sintering technique (SLS). Collagen type I was further coated onto PCL-TCP scaffolds to form PCL-TCP-COL scaffolds. The physical characters of these three scaffolds were analysed. The osteogenic potential of porcine adipose-derived stem cells (pASCs) was compared among these three scaffolds in order to find an optimal scaffold for bone tissue engineering. The experimental results showed no significant differences in pore size and porosity among the three scaffolds; the porosity was ca. 75-77% and the pore size was ca. 300-500 µm in all three. The compressive modulus was increased from 6.77 ± 0.19 to 13.66 ± 0.19 MPa by adding 30% β-TCP into a 70% PCL scaffold. No significant increase of mechanical strength was found by surface-coating with collagen type I. Hydrophilicity and swelling ratios showed statistical elevation (p < 0.05) after collagen type I was coated onto the PCL-TCP scaffolds. The in vitro study demonstrated that pASCs had the best osteogenic differentiation on PCL-TCP-COL group scaffolds, due to the highest ALP activity, osteocalcin mRNA expression and mineralization. A nude mice experiment showed better woven bone and vascular tissue formation in the PCL-TCP-COL group than in the PCL group. In conclusion, the study demonstrated the ability to fabricate 3D, porous PCL-TCP composite scaffolds (PCL:TCP = 70:30 by weight) via an in-house-built SLS technique. In addition, the osteogenic ability of pASCs was found to be enhanced by coating COL onto the PCL-TCP scaffolds, both in vitro and in vivo. Copyright © 2013 John Wiley & Sons, Ltd.
Die Veränderungen des Stuhlfettsäuremusters nach Leinölbelastung und ihr diagnostischer Wert zur Beurteilung der Fettresorption (1969)

Die gestörte Resorption im Intestinaltrakt (Maldigestion und/oder Malabsorption) kann eine oder mehrere Nahrungskomponenten betreffen.
Kaurane Diterpenoids fromIsodon excisusInhibit LPS-Induced NF-κB Activation and NO Production in Macrophage RAW264.7 Cells (2007)

As part of an ongoing search for plant-derived compounds that inhibit the activation of NF-kappaB, the methanol extract of the aerial parts of Isodon excisus was found to have significant inhibitory effects on the activation of NF-kappaB in murine macrophage RAW264.7 cells. Bioactivity-guided isolation of the extract yielded five new diterpenoids, excisusin A-E (1-5), along with seven known compounds, inflexarabdonin I (6), inflexarabdonin G (7), inflexin (8), inflexanin A (9), inflexanin B (10), inflexinol (11), and inflexarabdonin A (12). The structures were determined by analysis of the spectroscopic data including 2D NMR. All of the isolates were evaluated for their inhibitory effects on LPS-induced NF-kappaB activation and nitric oxide production in RAW264.7 cells.
Fault location identification in smart distribution networks with Distributed Generation (2015)

In this paper, based on the measurements available from the smart grid devices such as Advanced Metering Infrastructure (AMI), Reclosers, Distributed Generators (DG) and other IEDs, a fault location identification method is proposed that can accurately identify the fault location. The algorithm is suitable for distribution networks with DG and smart measurement infrastructure that can transmit event-driven data such as pre and post-fault voltages or currents of scarce number of meters. A MATLAB-based state estimation (SE) technique is applied to identify the fault location, and the open source tool OpenDSS is used to perform the offline validation by creating faults in simulation. The IEEE 37 node test feeder was modified to add DGs at different locations and was used for the validation of the proposed algorithm. Multiple faults (both symmetrical and unsymmetrical) were created for the exhaustive validation of the technique. In more than 90% of the cases the location was identified in the first guess and for the remaining 10% it took second guess and the faulted node was indeed near to the first guess.
Chimera: a declarative language for streaming network traffic analysis (2012)

Intrusion detection systems play a vital role in network security. Central to these systems is the language used to express policies. Ideally, this language should be powerful, implementation-agnostic, and cross-platform. Unfortunately, today’s popular intrusion detection systems fall short of this goal. Each has their own policy language in which expressing complicated logic requires implementation-specific code. Database systems have adapted SQL to handle streaming data, but have yet to achieve the efficiency and flexibility required for complex intrusion detection tasks. In this paper, we introduce Chimera, a declarative query language for network traffic processing that bridges the gap between powerful intrusion detection systems and a simple, platform-independent SQL syntax. Chimera extends streaming SQL languages to better handle network traffic by adding structured data types, first-class functions, and dynamic window boundaries. We show how these constructs can be applied to realworld scenarios, such as side-jacking detection and DNS feature extraction. Finally, we describe the implementation and evaluation of a compiler that translates Chimera queries into low-level code for the Bro event language. 1
Real-time prompt gamma monitoring in spot-scanning proton therapy using imaging through a knife-edge-shaped slit (2011)

In this paper we report on Monte Carlo simulations to investigate real-time monitoring of the track depth profile in particle therapy by measuring prompt gamma ray emissions: a high sensitivity imaging system employing a knife-edge-shaped slit combined with a position-sensitive gamma detector was evaluated. Calculations to test this new concept were performed for a head-sized software phantom. Clear spatial correlation is shown between the distribution of gamma rays detected with energies above 1.5 MeV and the distribution of prompt gamma rays emitted from the phantom. The number of neutrons originating from nuclear reactions in the phantom that are detected at these high energies is small. Most importantly it is shown that under common therapy conditions enough data may be collected during one spot-step (of the order of 10 ms) to locate the distal dose edge with a 1σ accuracy of better than 1 mm. This indicates that simple slit cameras have high potential for accurate real-time particle therapy adjustment and may become a practical way to improve particle therapy accuracy.
Research on directional stability analysis and control method of spatial data transmission antenna (2022)

The space data transmission antenna system is an important channel for the telemetry data transmission of the satellite platform to the ground. Therefore, the logarithmic antenna has high requirements for the pointing stability to the ground. The pointing accuracy of the data transmission antenna is seriously affected by the vibration of the satellite platform. Therefore, this paper analyzes the vibration of an orbiting spaceborne data transmission antenna, models, simulates, analyzes and calculates the logarithmic transmission antenna, optimizes the antenna system structure based on this, and designs a fuzzy adaptive PID control system under decentralized control for closed-loop control, The simulation test of the antenna system under the real vibration environment is carried out through the vibration test. The results show that the antenna system has stable performance and can effectively suppress the vibration, which verifies the reliability and feasibility of the antenna system. At present, the data transmission antenna has been put into orbit with satellite launch, and its performance indexes are stable, the research results can be used as a reference to improve the vibration safety of relevant spaceborne antennas.
Proteomic screening identifies a YAP-driven signaling network linked to tumor cell proliferation in human schwannomas (2014)

Tumor cell proliferation in human schwannomas is linked to a signaling network controlled by the Hippo effector YAP. Her2, Her3, PDGFRß, Axl, and Tie2, as well as YAP, represent potentially valuable therapeutic targets. However, the variability of their expression between tumors may result in strong differences in the response to targeted therapy.
Modeling of the electron distribution based on bremsstrahlung emission during lower hybrid current drive on PLT (1985)

Lower hybrid current drive requires the generation of a high energy electron tail anisotropic in velocity. Measurements of bremsstrahlung emission produced by this tail are compared with the calculated emission from reasonable model distributions. The physical basis and the sensitivity of this modeling process are described and the plasma properties of current driven discharges which can be derived from the model are discussed.
Do quality report cards play a role in HMOs' contracting practices? Evidence from New York State. (2000)

Despite a professed preference for high-quality surgeons, the use of publicly available quality reports by MCOs is currently low, and contracting practices for the majority of MCOs do not indicate a systematic selection either for or against surgeons based on their reported mortality scores. This study suggests that policy initiatives to increase the effective use of report cards should be encouraged.
Adaptive Control of Sewerage Systems using Distributed Reinforcement Learning (2003)

In this paper, we propose a new simulation-based Distributed Reinforcement Learning approach that solves large planning problems under uncertain environment. The proposed method is a distributed state-action representation for softening an interaction and reward design for making agents cooperate. We apply it to real sewerage control systems, as the problem with uncertainty. Simulation results show it finds good control rules, which can cope with various situations, by dealing with the uncertainty included in real data directly on a simulator based on real systems.
Supplementary Methods from Higher Frequencies of GARP<sup>+</sup>CTLA-4<sup>+</sup>Foxp3<sup>+</sup> T Regulatory Cells and Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma Patients Are Associated with Impaired T-Cell Functionality (2023)

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The MERL/SRI system for the 3RD CHiME challenge using beamforming, robust feature extraction, and advanced speech recognition (2015)

This paper introduces the MERL/SRI system designed for the 3rd CHiME speech separation and recognition challenge (CHiME-3). Our proposed system takes advantage of recurrent neural networks (RNNs) throughout the model from the front speech enhancement to the language modeling. Two different types of beamforming are used to combine multi-microphone signals to obtain a single higher quality signal. Beamformed signal is further processed by a single-channel bi-directional long short-term memory (LSTM) enhancement network which is used to extract stacked mel-frequency cepstral coefficients (MFCC) features. In addition, two proposed noise-robust feature extraction methods are used with the beamformed signal. The features are used for decoding in speech recognition systems with deep neural network (DNN) based acoustic models and large-scale RNN language models to achieve high recognition accuracy in noisy environments. Our training methodology includes data augmentation and speaker adaptive training, whereas at test time model combination is used to improve generalization. Results on the CHiME-3 benchmark show that the full cadre of techniques substantially reduced the word error rate (WER). Combining hypotheses from different robust-feature systems ultimately achieved 9.10% WER for the real test data, a 72.4% reduction relative to the baseline of 32.99% WER.
Mechanisms in the Reaction of Palladium(II)–π‐Allyl Complexes with Aryl Halides: Evidence for NHC Exchange Between Two Palladium Complexes (2009)

A detailed experimental and DFT study (PBE level) of the reaction of [Pd(eta(3)-C(3)H(5))(tmiy)(PR(3))]BF(4) (tmiy = tetramethylimidazolin-2-ylidene, PR(3) = phosphane), precursors to monoligated Pd(0) species, with aryl electrophiles yielding 2-arylimidazolium salt is reported. Experiments establish that an autocatalytic ligand transfer mechanism is preferred over Pd(IV) and sigma-bond metathesis pathways, and that transmetalation is the rate-determining step. Calculations indicate that the key step involves the concerted exchange of NHC and iodo ligands between two different Pd(II) complexes. This is corroborated by experimental results showing the slower reaction of complexes containing the bulkier dipdmiy (dipdmiy = diisopropyldimethylimidazolin-2-ylidene).
NEW METHOD FOR ESTIMATING DURABILITY OF POLYCARBONATE USED IN RAILWAY TRACK (1984)

The purpose of this study is to develop a method of estimating the practical durability of polycarbonate applied to railway tracks. Polycarbonate has been widely used as a rail insulating material, but it sometimes deteriorated sooner than expected. The author tried to estimate the practical durability in the laboratory and developed the C-type method. By comparing laboratory data obtained by the C-type method with field test results, it is concluded that this method is useful for estimating the practical durability of polycarbonate in railway tracks, and is applicable to other dynamic uses as well as to other kinds of plastics and rubber.
Catalytic Antibodies as Probes of Evolution: Modeling of a Primordial Glycosidase (1996)

The hydrolysis of unactivated cyclic ketals such as 1 can be catalyzed by antibodies raised against the transition state analog 2. This transformation is closely related to the cleavage of the glycosidic bond. The observed catalysis is triggered more by electrostatic complementarity to the transition state than by shape complementarity.
Tubular mesophases: liquid crystals consisting of macrocyclic molecules (1985)

The hexa-(p-n-dodecyloxybenzoyl) derivatives (1b), (2b), and (3b) of the macrocyclic polyamines [18]-N6, [24]-N6O2, and [27]-N6O3 display a liquid crystal phase in which the macrocyclic units are stacked, forming a tubular mesophase.
Integrating targeted drugs with taxanes and platinums: opportunities and challenges (2017)

In ovarian cancer, multiple attempts to adjust the standard taxane/platinum doublet by adding cytotoxic therapy or varying scheduling, dosage, and delivery have been met with limited success. Alternative methods to improve the grim prognosis of ovarian cancer, including molecular therapies, are currently under investigation. Efforts have been made to study tyrosine kinase inhibitors (including imatinib and pazopanib), Src kinase inhibitors and histone deacetylase inhibitors (HDACi) in combination with taxanes/platinums in order to improve efficacy. Unfortunately, while many pre-clinical and early phase clinical trials argue that the utilization of these molecular targets may enhance survival, only modest benefit has been seen in larger clinical trials. Other agents that have been evaluated include proteasome inhibitors, folate receptor antagonists, MEK inhibitors and opiate antagonists. In this review, we discuss the mechanisms of these targeted therapies and highlight the current and ongoing clinical trials that utilize these targeted agents in combination with taxanes and platinums in advanced ovarian cancer.
An update on the blood vessel in migraine (2010)

Migraine is accompanied by significant derangements in vascular function that may represent important targets for investigation and treatment.
Application of Polylactic Acid Polymer in the Treatment of Acute Maxillary Sinusitis in Rabbits (1995)

To evaluate the therapeutic effects of topical antibiotic delivered by polylactic acid (PLA) polymer on paranasal sinusitis, we induced maxillary sinusitis in 32 New Zealand white rabbits by obstructing the maxillary sinus ostium and inoculating the sinus cavity with Streptococcus pneumoniae. The rabbits were divided into three groups: a control group (group 1) treated only by reopening the ostium, a group (group 2) treated by both reopening the ostium and injecting ampicillin (40 mg/kg/day), and a group (group 3) in which ampicillin in the PLA carrier (0.326 mg) was placed within the sinus after ostial patency was reestablished. The number of colony forming units (CFU) was lowest in group 3, followed by groups 2 and 1. Ampicillin concentration in the maxillary sinus secretion of group 3 was significantly higher than in group 2. The results suggest that treatment with PLA-ampicillin polymer may maintain high therapeutic concentrations of ampicillin in maxillary sinus secretion.