gebhart/patrepeval huggingface dataset:
検査法 EOS system : 低照射線量による新しい立位放射線撮影機器 (2013)

In recent years, lumpy skin disease virus has extended its geographical range outside of endemic sub-Saharan countries to the Middle East and Asia indicating transboundary spread. Recently, lumpy skin disease (LSD) outbreaks have been reported in Asian countries such as Bangladesh, India, China, Nepal, Bhutan, Vietnam, Myanmar, Sri Lanka, Thailand, Malaysia, Laos and for the first time and represent a cause of serious concern for their livestock and dairy industries. This report summarizes information on the recent outbreaks of LSD in southern Asia and emphasizes the threat it poses to neighbouring countries. Various strategies and actions needed to control outbreaks of this emerging disease in Asia are also suggested.
Tattoo Formation from Absorbable Synthetic Suture and Successful Removal with Q-Switched Ruby Laser (1996)

We report on the occurrence of a traumatic tattoo resulting from synthetic suture material and complete removal with the Q-switched ruby laser.
Construction and characterization of an ovine BAC contig spanning the callipyge locus. (2000)

International audience
Total systematic noise reduction in Fourier transform nuclear magnetic resonance spectrometry (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal systematic noise reduction in Fourier transform nuclear magnetic resonance spectrometryRobert E. Santini and John B. GrutznerCite this: Anal. Chem. 1976, 48, 6, 941–943Publication Date (Print):May 1, 1976Publication History Published online1 May 2002Published inissue 1 May 1976https://pubs.acs.org/doi/10.1021/ac60370a024https://doi.org/10.1021/ac60370a024research-articleACS PublicationsRequest reuse permissionsArticle Views85Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The role of rosetting in the multiplication of Plasmodium falciparum: rosette formation neither enhances nor targets parasite invasion into uninfected red cells (1998)

The effect of rosette formation on the multiplication in vitro of Plasmodium falciparum was studied in order to establish whether rosetting acts as a major virulence factor in the pathogenesis of severe malaria by facilitating invasion of uninfected red cells. Invasion rates for rosetting (R+) and non-rosetting (R-) parasites selected from the same clone, PA1, of P. falciparum were similar over a range of starting parasite concentrations when assayed in both static cultures and conditions of shear stress comparable with microvascular flow. However, incubation of both R+ and R- parasites under simulated conditions of flow led to decreased invasion and fewer multiply-infected red cells as we have previously observed. Studies using fluorescently labelled red cells or reticulocytes demonstrated that rosetting did not alter the rates of invasion or target merozoites into the uninfected cells comprising a rosette. Preferential invasion of reticulocytes occurred regardless of rosetting or conditions of flow. Although the role of rosetting in the pathogenesis of malaria might relate to microvascular obstruction or perhaps the restriction of phagocytosis, our data suggest that rosetting does not play a role in the invasion or targeting of parasites into uninfected cells, eliminating this mechanism to explain the association of virulence with the rosetting parasite phenotype.
The SIRT2/cMYC Pathway Inhibits Peroxidation-Related Apoptosis In Cholangiocarcinoma Through Metabolic Reprogramming (2019)

Cholangiocarcinoma (CCA) is a malignant cancer with an unknown etiology and an unfavorable prognosis. Most patients are diagnosed at an advanced stage, thus making it essential to find novel curative targets for CCA. Metabolic reprogramming of the tumor cells includes metabolic abnormalities in glucose (known as the Warburg effect) and other substances such as amino acids and fats. Metabolic reprogramming produces anti-oxidant substances, reduces tumor oxidative stress, and finally promotes the proliferation of tumors. There is increasing evidence to imply that SIRT2, a histone deacetylase, and its downstream target cMYC, play metabolic regulatory roles in tumor cells. However, the role of the SIRT2/cMYC pathway in CCA is unclear. To assess the metabolic reprogramming function of the SIRT2/cMYC pathway in CCA and to determine the downstream targets as well as evaluate the therapeutic effect, the CCA RNA-Seq data were downloaded from the TCGA database. Differentially expressed genes were confirmed and KEGG pathway enrichment analysis was performed. Overall, 48 paired CCA samples were collected and subjected to immunohistochemical detection, and the clinical characteristics of participants were summarized. The CCA cells were suppressed or overexpressed with different downstream targets of SIRT2 and then subjected to apoptosis, immunoblotting, seahorse, and metabolites tracing analysis. In vivo experiments were also performed. We found that the SIRT2/cMYC pathway contributed to the proliferation of CCA cells and confirmed that the downstream target is PHDA1 and the serine synthesis pathway. The up-regulated SIRT2 and cMYC levels resulted in low levels of mitochondrial oxidative phosphorylation and increased conversion of glucose to serine and led to poor patient survival. The highly active SIRT2/cMYC pathway up-regulated the serine synthesis pathway pyruvate and increased antioxidant production, thus consequently protecting the CCA cells from oxidative stress-induced apoptosis. Our data revealed that the SIRT2/cMYC pathway plays a critical role in transforming glucose oxidative metabolism to serine anabolic metabolism, thus providing antioxidants for stress resistance. SIRT2/cMYC-induced metabolic reprogramming may represent a new therapeutic target for treating CCA.
Supporting Air-Conditioning Controller Design Using Evolutionary Computation (2008)

In recent years, as part of the remarkable development of electronic techniques, electronic control has been applied to various systems. Many sensors and actuators have been implemented into those systems, and energy efficiency and performance have been greatly improved. However, these systems have been complicated, and much time has been required to develop system controllers. In this paper, a method of automatic controller design for those systems is described. In order to automate the design of an electronic controller, an evolutionary hardware is applied. First, the framework for applying the genetic algorithm to the automation of controller design is described. In particular, the coding of a chromosome is shown in detail. Then, how to make a fitness function is represented, with an air conditioner as an example, and the controller of the air conditioner is developed automatically using our proposed framework. Finally, an evolutionary simulation is performed to confirm our framework.
Unusual Case of an Arterial Thoracic Outlet Syndrome due to Srb Anomaly (2013)

A thoracic outlet syndrome (TOS) is caused by arterial or nervous obstruction because of skeletal or muscular anomalies and hypertrophies. Congenital rib anomalies occur with low incidences (0.15-0.31%), predominantly affect the right side and are normally diagnosed at a young age or remain asymptomatic throughout life. Here, we report on the unusual case of a 71-year-old female patient with subacute ischemia of the left arm due to a TOS resulting from Srb anomaly, a very rare congenital rib anomaly.
P-waves imaging of the FRI and BK zones at the Grimsel Rock Laboratory (1990)

This report is one of a series documenting the results of the Nagra-DOE Cooperative (NDC-I) research program in which the cooperating scientists explore the geological, geophysical, hydrological, geochemical, and structural effects anticipated from the use of a rock mass as a geological repository for nuclear waste. Tomographic imaging studies using a high frequency (10 Khz.) piezoelectric source and a three component receiver were carried out in two different regions of the underground Nagra Grimsel test facility in Switzerland. Both sites were in fractured granite, one being in a strongly foliated granite (FRI site), and the other being in a relatively homogeneous granite (BK zone). The object of the work was to determine if the seismic techniques could be useful in imaging the fracture zones and provide information on the hydrologic conditions. Both amplitude and velocity tomograms were obtained from the Data. The results indicate that the fracture zones strongly influenced the seismic wave propagation, thus imaging the fracture zones that were hydrologically important. 11 refs., 24 figs.
Boron‐Based Hybrid Nanostructures: Novel Applications of Modern Materials (2011)

This chapter reviews some of the recent developments in the use of nanoparticles as adjuncts to boron containing compounds in boron neutron capture therapy (BNCT) or, in the cases of boron nanotubes (BNTs) and boron nitride nanotubes (BNNTs), the boron agent itself. BNCT is a bimodal therapy in which boron-10 is preferentially localized in a cancer cell and then irradiated with low energy (thermal) neutrons. The B absorbs the neutron giving an excited B, which immediately undergoes a fission reaction yielding a high energy alpha (a) particle and recoil Li particle, plus a low energy gamma (g) ray. The therapeutic advantage of this method is that the two charged particles deposit their energy through a distance of 9mm, which is of the order of a cell dimension. Therefore, damage will be confined to the cell in which fission reaction occurs, sparing neighboring cell that are free of boron. The chemical challenge in BNCT is constructing molecules or delivery agents that preferentially target neoplastic cells. Although this requirement is common to all chemotherapy, the required amount of B needed for effective BNCT (10–35 mg/g tumor cell) is much higher than that required in other forms of chemotherapy. A number of macromolecular entities and new delivery methods used in BNCTare discussed. They include liposomes, dendrimers, carbon nanotubes (CNTs), BNTs and BNNTs, and magnetic nanoparticles. References are given to some of the latest applications.
Stacking nonenzymatic circuits for high signal gain (2013)

Signal amplification schemes that do not rely on protein enzymes show great potential in areas as abstruse as DNA computation and as applied as point-of-care molecular diagnostics. Toehold-mediated strand displacement, a programmable form of dynamic DNA hybridization, can be used to design powerful amplification cascades that can achieve polynomial or exponential amplification of input signals. However, experimental implementation of such amplification cascades has been severely hindered by circuit leakage due to catalyst-independent side reactions. In this study, we systematically analyzed the origins, characteristics, and outcomes of circuit leakage in amplification cascades and devised unique methods to obtain high-quality DNA circuits that exhibit minimal leakage. We successfully implemented a two-layer cascade that yielded 7,000-fold signal amplification and a two-stage, four-layer cascade that yielded upward of 600,000-fold signal amplification. Implementation of these unique methods and design principles should greatly empower molecular programming in general and DNA-based molecular diagnostics in particular.
Modeling INK4/ARF Tumor Suppression in the Mouse (2007)

The INK4/ARF locus encodes the p15(INK4B), p16(INK4A) and p14(ARF) tumor suppressor proteins whose loss of function is associated with the pathogenesis of many human cancers. Dissecting the relative contribution of these genes to growth control in vivo is complicated by their physical contiguity and the frequency of homozygous deletions that inactivate all three components of this locus. While genetically engineered mouse models provide a rigorous system for elucidating cancer gene function, there is some evidence to suggest there are cross-species differences in regulating tumor biology. Given the prevalence of mouse models in cancer research and the potential contribution of such models to preclinical studies, it is important determine to what degree the function of these critical tumor suppressors is conserved between organisms. In this review, we assess the relative biological roles of INK4A, INK4B and ARF in mice and humans with the aim of determining the faithfulness of mouse models and also of obtaining insights into the pattern of specific tumor types that are associated with germline and somatic mutations at components of this locus. We will discuss 1) the contribution of INK4A, INK4B and ARF to growth control in vitro in a series of cell types, 2) the in vivo phenotypes associated with germline loss of function of this locus and 3) the study of Ink4a and Arf in different cancer-specific mouse models.
Suppression of MRI Truncation Artifacts Using Total Variation Constrained Data Extrapolation (2008)

The finite sampling of k-space in MRI causes spurious image artifacts, known as Gibbs ringing, which result from signal truncation at the border of k-space. The effect is especially visible for acquisitions at low resolution and commonly reduced by filtering at the expense of image blurring. The present work demonstrates that the simple assumption of a piecewise-constant object can be exploited to extrapolate the data in k-space beyond the measured part. The method allows for a significant reduction of truncation artifacts without compromising resolution. The assumption translates into a total variation minimization problem, which can be solved with a nonlinear optimization algorithm. In the presence of substantial noise, a modified approach offers edge-preserving denoising by allowing for slight deviations from the measured data in addition to supplementing data. The effectiveness of these methods is demonstrated with simulations as well as experimental data for a phantom and human brain in vivo.
Team Membership Change and the Critical Role of Communication (2016)

the University of Calgary under the supervision of Dr. Tom O'Neill. Her area of focus is teams within organizational contexts and that results in a plethora of research conducted with
Goldilocks Effect of a Distal Substituent on Living Ziegler−Natta Polymerization Activity and Stereoselectivity within a Class of Zirconium Amidinate-Based Initiators (2004)

A new series of cationic zirconium amidinates, [(η5-C5Me5)ZrMe{N(Et)C(R3)N(tBu)}][B(C6F5)4] (R3 = Me, H, Ph, and tBu) (1a−d), were synthesized and their ability to function as initiators for the stereoselective living Ziegler−Natta polymerization of 1-hexene evaluated. Whereas 1a is highly active for the isospecific living polymerization of 1-hexene as previously reported, polymerizations conducted with 1b and 1c both display a significant loss of stereocontrol, and in the case of 1b, the polymerization is no longer living. Further, 1d was found to be inactive for polymerization. The Golidlocks effect observed for the distal R3 substituent in this series, i.e., 1b “too small”, 1c “too large”, 1a “just right”, appears to be steric in origin. Solution and solid state structural studies suggest, however, that two different mechanisms are most likely operative for the loss of stereocontrol observed for 1b and 1c: a low barrier to metal-centered epimerization in the case of 1b and a lack of steric discrimination at the metal center for olefin binding in the case of 1c.
First-in-human trial of blood–brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound (2019)

MR-guided focused ultrasound (MRgFUS) is an emerging technology that can accurately and transiently permeabilize the blood-brain barrier (BBB) for targeted drug delivery to the central nervous system. We conducted a single-arm, first-in-human trial to investigate the safety and feasibility of MRgFUS-induced BBB opening in eloquent primary motor cortex in four volunteers with amyotrophic lateral sclerosis (ALS). Here, we show successful BBB opening using MRgFUS as demonstrated by gadolinium leakage at the target site immediately after sonication in all subjects, which normalized 24 hours later. The procedure was well-tolerated with no serious clinical, radiologic or electroencephalographic adverse events. This study demonstrates that non-invasive BBB permeabilization over the motor cortex using MRgFUS is safe, feasible, and reversible in ALS subjects. In future, MRgFUS can be coupled with promising therapeutics providing a targeted delivery platform in ALS.
Performance and Aging of Mn/MnO2 as an Environmentally Friendly Energetic Time Delay Composition (2014)

The Mn/MnO2 reactive system was investigated as a suitable replacement for the traditional W/BaCrO4/KClO4/diatomaceous earth delay composition. The delay performance, ignition sensitivity, and aging characteristics were examined in aluminum microchannels similar in diameter to common delay housings (4.7 mm). Stoichiometries with measured combustion temperatures between 1358 and 2113 K were self-sustaining with combustion velocities ranging from 2.4 to 7.3 mm s–1. The Mn/MnO2 system produced less gas than W/BaCrO4/KClO4/diatomaceous earth compositions allowing consideration for use in sealed delay housings. Accelerated aging at 70 °C and 30% relative humidity for 8 weeks resulted in no measurable loss of performance. Safety characterization showed that this composition is not sensitive to ignition by friction or electrostatic stimuli. The combustion products (as determined by X-ray diffraction) appear to be benign based on current regulations. Therefore, the Mn/MnO2 system appears to be a suitable low gas-producing, nonsensitive, less toxic delay composition with good longevity.
Design and Control of a Thermally Coupled Reactive Distillation Process Synthesizing Diethyl Carbonate (2014)

Diethyl carbonate (DEC) is a versatile material due to its excellent chemical and physical properties. Several chemical routes have been reported for the preparation of DEC. However, they suffer the drawbacks of using poisonous gases or attaining a low yield of DEC. In this study, a promising route by the transesterification of propylene carbonate and ethanol is used to coproduce DEC and propylene glycol. The transesterification reaction offers an excellent green chemical process. However, the reaction is a typically equilibrium-limited one. Reactive distillation (RD) with excess reactant is adopted in the study to improve reaction conversion and obtain high-purity products in the DEC synthesis. A base-case design, consisting of a RD column and a DEC purification column with its overhead unreacted ethanol stream recycled back to the RD column, is developed and optimized by minimizing the total annual cost. An alternative thermally coupled RD process is also developed which results in substantially reduced energy consumption. Further, steady-state analysis is used to design the control strategies of the thermally coupled RD process. It has been demonstrated that the proposed temperature control + constant reflux-ratio control scheme is sufficient to maintain not only feed ratio of the reactants but also product purities at or around their designed values for the RD process with thermal coupling.
Isolation and differentiation of herpes simplex virus and Trichomonas vaginalis in cell culture (1985)

During the period January 1982 to January 1985, 2,234 specimens were cultured for isolation of herpes simplex virus (HSV). HSV was isolated from 23% of these, Trichomonas vaginalis was isolated from 1.6%, and 75.3% were negative. In 0.2% of these, HSV and T. vaginalis were isolated from the same specimen. Cytopathic effects produced by HSV were identified by their sensitivity to arabinosylthymine, whereas those produced by T. vaginalis were identified by their lack of sensitivity to arabinosylthymine and by observation of motility. Cytopathic effects produced by T. vaginalis were reproduced by trophozoites from axenic cultures of T. vaginalis as well as by lysates of T. vaginalis added to serum-free BHK cells.
Synthesis and Solution Conformation ofβ-Hairpin Mimetics Utilizing a Template Derived from (2S,3R,4R)-Diaminoproline (2000)

A novel template was synthesized for stabilizing β-hairpin conformations in cyclic peptide mimetics. The template is a diketopiperazine derived formally from L-aspartic acid and (2S,3R,4R)-diaminoproline, the latter being available by an efficient synthetic route from vitamin C. The template was incorporated by solid-phase peptide synthesis into a cyclic loop mimetic containing the sequence (-Ala-Asn-Pro-Asn-Ala-Ala-template-). This mimetic was shown by NMR to adopt a stable β-hairpin conformation in (D6)DMSO solution. The template may prove to be generally useful for creating small-molecule mimetics of hairpin loops on proteins of diverse function.
Interaction of alkyl halides with the di-ironoctacarbonylate anion: the crystal structures of the tetraethylammonium salts of the µ-acetyl-C1(Fe1, Fe2)O(Fe1, Fe3)-nonacarbonyl-triangulo-triferrate and µ2-carbonylnonacabonyl-µ3-2,4-dioxapentylidyne-triangulo-triferrate anions (1981)

The di-iron carbonylate anion [Fe2(CO)8]2– reacts with methyl iodide and with chloromethyl methyl ether to give, respectively, the tri-iron cluster anions [Fe3(CO)9(µ-MeCO)]– and [Fe3(CO)9(µ-CO)(µ3-COCH2–OMe)]–, the former having a new type of bridging acetyl group.
Comparative studies of the enzymes involved in the metabolism of 2,3-bisphosphoglycerate in pig and in cat tissues. (1983)

The enzymes with 2,3-bisphosphoglycerate synthase and 2,3-bisphosphoglycerate phosphatase activity present in pig and in cat tissues have been isolated and partially characterized. It is concluded that regulation of 2,3-bisphosphoglycerate metabolism differ in erythrocytes and in tissue cells.
Cytocompatibility of high strength non‐oxide ceramics (2009)

Oxide ceramic materials like alumina (Al(2)O(3)) and zirconia (ZrO(2)) are frequently used for medical applications like implants and prostheses because of their excellent biocompatibility and high wear resistance. Unfortunately, oxide ceramics cannot be used for minimal invasive thin-walled implants like resurfacing hip prostheses because of their limited strength. The hypothesis of this study is that non-oxide ceramics like silicon nitride (Si(3)N(4)) and silicon carbide (SiC)-not previously used in the medical field-are not only high strength and mechanically reliable ceramic materials due to their high amount of covalent bonds, but also exhibit a suitable biocompatibility for use as medical implants and prostheses. Mechanical investigations and cell culture tests with mouse fibroblast cells (L929) and human mesenchymal stem cells (hMSC) were performed on the ceramics. An excellent cytocompatibility was demonstrated by live/dead stainings for both L929 cells and hMSC. HMSC were able to differentiate towards osteoblasts on all tested ceramics. The determined strength of silicon nitride and silicon carbide was shown as significantly higher than that of oxide ceramics. Our results indicate that the high strength non-oxide ceramics are material candidates in the future especially for highly loaded, thin-walled implants like ceramic resurfacing hip prostheses.