gebhart/patrepeval huggingface dataset:
Call to Action on Use and Reimbursement for Home Blood Pressure Monitoring (2008)

Home blood pressure monitoring (HBPM) overcomes many of the limitations of traditional office blood pressure (BP) measurement and is both cheaper and easier to perform than ambulatory BP monitoring. Monitors that use the oscillometric method are currently available that are accurate, reliable, easy to use, and relatively inexpensive. An increasing number of patients are using them regularly to check their BP at home, but although this has been endorsed by national and international guidelines, detailed recommendations for their use have been lacking. There is a rapidly growing literature showing that measurements taken by patients at home are often lower than readings taken in the office and closer to the average BP recorded by 24-hour ambulatory monitors, which is the BP that best predicts cardiovascular risk. Because of the larger numbers of readings that can be taken by HBPM than in the office and the elimination of the white-coat effect (the increase of BP during an office visit), home readings are more reproducible than office readings and show better correlations with measures of target organ damage. In addition, prospective studies that have used multiple home readings to express the true BP have found that home BP predicts risk better than office BP (Class IIa; Level of Evidence A). This call-to-action article makes the following recommendations: (1) It is recommended that HBPM should become a routine component of BP measurement in the majority of patients with known or suspected hypertension; (2) Patients should be advised to purchase oscillometric monitors that measure BP on the upper arm with an appropriate cuff size and that have been shown to be accurate according to standard international protocols. They should be shown how to use them by their healthcare providers; (3) Two to 3 readings should be taken while the subject is resting in the seated position, both in the morning and at night, over a period of 1 week. A total of >/=12 readings are recommended for making clinical decisions; (4) HBPM is indicated in patients with newly diagnosed or suspected hypertension, in whom it may distinguish between white-coat and sustained hypertension. If the results are equivocal, ambulatory BP monitoring may help to establish the diagnosis; (5) In patients with prehypertension, HBPM may be useful for detecting masked hypertension; (6) HBPM is recommended for evaluating the response to any type of antihypertensive treatment and may improve adherence; (7) The target HBPM goal for treatment is <135/85 mm Hg or <130/80 mm Hg in high-risk patients; (8) HBPM is useful in the elderly, in whom both BP variability and the white-coat effect are increased; (9) HBPM is of value in patients with diabetes, in whom tight BP control is of paramount importance; (10) Other populations in whom HBPM may be beneficial include pregnant women, children, and patients with kidney disease; and (11) HBPM has the potential to improve the quality of care while reducing costs and should be reimbursed.
Plasma Transferred Wire Arc Spraying of Novel Wire Feedstock onto Cylinder Bore Walls of ALSI Engine Blocks (2008)

Abstract Hypoeutectic AlSi engine blocks of modern passenger cars are generally equipped with cast iron liners in order to provide cylinder running surfaces that meet the tribological requirements. A very promising alternative to the use of cylinder liners lies within the application of thermally sprayed coatings onto the walls of cylinder bores as friction partners for the piston rings. This work describes the development of a novel iron based wire feedstock as well as its application by the Plasma Transferred Wire Arc internal diameter coating system. The material developed within the frame of this work leads to partially amorphous coatings with embedded nanoscale precipitations if processed by thermal spraying. The coatings were applied onto the inner diameters of test liners made of Aluminium EN AW 6060 and onto cylinder bore walls of in-line 4 cylinder engines. All substrates were mechanically roughened in order to obtain high bond strengths of the sprayed coatings. The coatings microstructure was analysed by light optical microscopy, hardness measuring by transmission electron microscopy. Furthermore the oil storage capacities of the honed surfaces were determined.
Adhesion of silver films to ion-bombarded silicon carbide: ion-dose dependence and Weibull statistical analysis of pull-test results (1994)

Silver films were deposited by evaporation onto polished silicon carbide substrates that had been sputtered for various lengths of time with 500 eV ions. The adhesion strength of the films was measured as a function of the ion bombardment time and species with a pull-type adhesion tester. Adhesion of Ag to argon-ion-sputtered surfaces was low except at the highest dose, in which case very good adhesion was measured. In contrast, oxygen/argon-ion sputtering produced a rapid rise in adhesion strength, but adhesion was limited to less than 60 MPa, even for lengthy bombardment. The applicability of Weibull statistical analysis to the distribution of pull-test failure strengths was investigated. A good fit of the data to the Weibull expression was observed. A significant Weibull threshold stress was found and the Weibull moduius was low.
Effects of the neurotrophic factors BDNF, NT-3, and FGF2 on dissociated neurons of the cochlear nucleus (2014)

The cochlear nucleus is the first relay station for acoustic information in the auditory pathway and its cellular integrity is affected by hearing loss. Neurotrophic factors, which are known to regulate fundamental processes in the brain, are expressed in the cochlear nucleus and are regulated by the changes in the stimulation. The aim of this study was to evaluate the effect of the neurotrophins Brain derived neurotrophic factor (BDNF) and Neurotrophin 3 (NT-3) and the neurotrophic factor Fibroblast growth factor 2 (FGF2) on primary cultured cells of the mouse cochlear nucleus. No effect on overall cell growth was detected after 8 days in culture by the factors applied. NT-3 had a strong impact on enhancement of neuronal survival, whereas BDNF stimulated neuronal survival and axonal outgrowth. Axonal branching was negatively affected by the administration of BDNF. FGF2 did not show any effect. The results presented represent fundamental research on auditory neurons, but might be one step toward defining novel therapeutic strategies in the future to prevent cochlear nucleus degeneration induced by hearing loss.
Qualitative Research in Sport Sciences: Is the Biomedical Ethics Model Applicable? (2008)

Research in sports science has historically been grounded in positivist traditions. This means that ethics committees may not be adequately sensitized to the ethical problems posed by qualitative research. Qualitative researchers may thus be disadvantaged in the research approval process. Our paper argues that the traditional biomedical ethics model may not always be appropriate in evaluating qualitative proposals. Due to the nature of its methods, qualitative work may have emergent and ongoing ethical issues that require consultation and resolution. We argue that, contrary to the judgements of many ethics committees, methods such as deception and covert observation can be justified if certain conditions are met. In reaffirming a commitment to the overarching ethical principle of respect for persons, we conclude that researchers need to recognize and plan for ethical issues in their work. Likewise, ethics committees need to recognize that qualitative work poses unique problems, but that these need not necessarily be insurmountable obstacles to project approval. URN: urn:nbn:de:0114-fqs0301121
Identification of multiple regulatory elements on the human cytochrome P450IA1 gene (1988)

To examine the transcriptional regulation of the human cytochrome P450IA1 gene, a 3574 bp fragment containing 1140 bp of 5' flanking sequences, exon 1 (leader information only), intron 1, and the leader sequences from exon 2, was cloned upstream of the reporter gene, chloramphenicol acetyltransferase, and used to transfect the human hepatoma cell line, HepG2. In transient expression assays, treatment of the transfected cells with 3-methylcholanthrene, benzo[a]pyrene or 2,3,7,8-tetrachlorodibenzofuran was shown to induce the expression of chloramphenicol acetyltransferase 10-fold. Previous studies by other investigators have identified a xenobiotic responsive element at greater than 800 bp 5' to the cap site in the mouse and rat cytochrome P450IA1 gene. In the current report, deletion of sequences from the 5' side of the P450IA1 fragment, as well as internal deletions, were used to identify at least three additional regulatory elements. A second positive, 3-methylcholanthrene responsive element was localized to sequences between -49 and -560 in addition to confirming the location of a similar element between -831 and -1140. These elements flank a potent negative regulatory element that has been conserved between the rat, mouse and human P450IA1 genes and also exhibits significant sequence identity with one of the negative control elements of the human c-Ha-ras1 proto-oncogene. Deletion of the negative control element clearly demonstrated that the fragments containing xenobiotic responsive elements also possess positive, constitutive control activity. A fourth element located within intron 1 was shown to potentiate the activity of 3-methylcholanthrene when the cells were treated simultaneously with the glucocorticoid agonist, dexamethasone.
Wnt Protein-mediated Satellite Cell Conversion in Adult and Aged Mice Following Voluntary Wheel Running (2014)

Muscle represents an abundant, accessible, and replenishable source of adult stem cells. Skeletal muscle-derived stem cells, called satellite cells, play essential roles in regeneration after muscle injury in adult skeletal muscle. Although the molecular mechanism of muscle regeneration process after an injury has been extensively investigated, the regulation of satellite cells under steady state during the adult stage, including the reaction to exercise stimuli, is relatively unknown. Here, we show that voluntary wheel running exercise, which is a low stress exercise, converts satellite cells to the activated state due to accelerated Wnt signaling. Our analysis showed that up-regulated canonical Wnt/β-catenin signaling directly modulated chromatin structures of both MyoD and Myf5 genes, resulting in increases in the mRNA expression of Myf5 and MyoD and the number of proliferative Pax7(+)Myf5(+) and Pax7(+) MyoD(+) cells in skeletal muscle. The effect of Wnt signaling on the activation of satellite cells, rather than Wnt-mediated fibrosis, was observed in both adult and aged mice. The association of β-catenin, T-cell factor, and lymphoid enhancer transcription factors of multiple T-cell factor/lymphoid enhancer factor regulatory elements, conserved in mouse, rat, and human species, with the promoters of both the Myf5 and MyoD genes drives the de novo myogenesis in satellite cells even in aged muscle. These results indicate that exercise-stimulated extracellular Wnts play a critical role in the regulation of satellite cells in adult and aged skeletal muscle.
Mythologies du XXIè siècle (2000)

Ruby Christian. Mythologies du XXIè siècle. In: Raison présente, n°136, 4e trimestre 2000. Mythologies du XXIè siècle. pp. 3-4.
Collagen VI regulates peripheral nerve myelination and function (2013)

Collagen VI is an extracellular matrix protein with broad distribution in several tissues. Although Col6a1 is expressed by Schwann cells, the role of collagen VI in the peripheral nervous system (PNS) is yet unknown. Here we show that Schwann cells, but not axons, contribute to collagen VI deposition in peripheral nerves. By using Col6a1-null mice, in which collagen VI deposition is compromised, we demonstrate that lack of collagen VI leads to increased myelin thickness (P<0.001) along with 60-130% up-regulation in myelin-associated proteins and disorganized C fibers in the PNS. The hypermyelination of PNS in Col6a1(-/-) mice is supported by alterations of signaling pathways involved in myelination, including increase of P-FAK, P-AKT, P-ERK1, P-ERK2, and P-p38 (4.15, 1.67, 2.47, 3.34, and 2.60-fold, respectively) and reduction of vimentin (0.49-fold), P-JNK (0.74-fold), and P-c-Jun (0.50-fold). Pathologically, Col6a1(-/-) mice display an impairment of nerve conduction velocity and motor coordination (P<0.05), as well as a delayed response to acute pain stimuli (P<0.001), indicating that lack of collagen VI causes functional defects of peripheral nerves. Altogether, these results indicate that collagen VI is a critical component of PNS contributing to the structural integrity and proper function of peripheral nerves.
Ultrafast Bessel beams for high aspect ratio taper free micromachining of glass (2010)

Although ultrafast lasers have demonstrated much success in structuring and ablating dielectrics on the micrometer scale and below, high aspect ratio structuring remains a challenge. Specifically, microfluidics or lab-on-chip DNA sequencing systems require high aspect ratio sub-10 &#956;m wide channels with no taper. Micro-dicing also requires machining with vertical walls. Backside water assisted ultrafast laser processing with Gaussian beams allows the production of high aspect ratio microchannels but requires sub-micron sample positioning and precise control of translation velocity. In this context, we propose a new approach based on Bessel beams that exhibit a focal range exceeding the Rayleigh range by over one order of magnitude. An SLM-based setup allows us to produce a Bessel beam with central core diameter of 1.5 &#956;m FWHM extending over a longitudinal range of 150 &#956;m. A working window in the parameter space has been identified that allows the reliable production of high aspect ratio taper-free microchannels without sample translation. We report a systematic investigation of the damage morphology dependence on focusing geometry and energy per pulse.
Growth hormone releasing hormone or growth hormone treatment in growth hormone insufficiency? (1988)

Sixteen prepubertal children who were insufficient for growth hormone were treated with growth hormone releasing hormone (GHRH) 1-40 and GHRH 1-29 for a mean time of nine months (range 6-12 months) with each peptide. Eleven children received GHRH 1-40 in four subcutaneous nocturnal pulses (dose 4-8 micrograms/kg/day) and eight (three of whom were also treated with GHRH 1-40) received GHRH 1-29 twice daily (dose 8-16 micrograms/kg/day). Altogether 73% of the children receiving GHRH 1-40 and 63% receiving GHRH 1-29 showed a growth response. Double the daily dose of GHRH 1-29 was required to obtain equivalent growth response to pulsatile GHRH 1-40. A significant linear correlation was shown between growth hormone secretion and height velocity on GHRH 1-40 but not on GHRH 1-29 and there was a significant correlation between plasma GHRH and serum growth hormone concentrations during GHRH 1-40 administration. Response to conventional growth hormone treatment in a matched group of children was significantly better than the response after GHRH. A significant improvement in height velocity was observed in the children transferred to growth hormone replacement. Growth hormone remains the treatment of choice in growth hormone insufficiency. GHRH treatment may be of benefit in children with less severe growth hormone insufficiency in the presence of pulsatile endogenous growth hormone secretion.
Tuite, gamma-Ca3(PO4)2: a new mineral from the Suizhou L6 chondrite (2004)

Tuite, γ-Ca 3 (PO 4 ) 2 , the high-pressure polymorph of whitlockite, was found in a shock melt vein of the Suizhou chondrite. It occurs as polycrystalline aggregates in association with coarse-grained aggregates of ringwoodite, majorite and NaAlSi 3 O 8 -hollandite. These high-pressure mineral assemblages are enclosed in the fine-grained matrix of the vein that consists of majorite-pyrope ss garnet, metal and troilite. This new mineral is trigonal, R 3 m,a = 5.258 A, c = 18.727 A. The tuite is colourless and transparent with vitreous lustre and white streak; it is uniaxial (+) with high refractive indices (ϵ = 1.706, ω = 1.701) and low birefringence (0.005). Microprobe analyses of tuite yield an empirical formula (Ca 2.51 Mg 0.29 ) 2.80 Na 0.28 (P 1.01 O 4 ) 2 . The simplified formula, Ca 3 (PO 4 ) 2 , is the same as whitlockite outside the veins. Stronger reflections on synchrotron radiation X-ray powder diffraction pattern of tuite are d = 2.628 (100), 2.891 (80), 1.945 (47), 1.730 (25) and 1.567(22). The figures in brackets are relative intensities. Tuite in the shock vein of this meteorite was transformed from whitlockite via a shock-produced solid-state reaction, while the pressure and temperature in the shock vein attained 23 GPa and 2000°C. This new mineral and the mineral name (tuite) have been approved by the Commission on New Minerals and Mineral Names of the International Mineralogical Association.
The Pathogenesis, Complications and Therapeutic Strategy for Hepatitis C Virus-associated Insulin Resistance in the Era of Anti-viral Treatment (2010)

Recent experimental and clinical studies have shown that chronic hepatitis C virus (HCV) infection causes insulin resistance. Since insulin resistance decreases response to antiviral treatments, promotes inflammatory and fibrogenic reactions and increases a risk of hepatocellular carcinoma (HCC), amelioration of insulin resistance may be a novel therapeutic target, which could improve the prognosis in patients with HCV-related chronic liver disease. Despite the increased awareness of health risk of insulin resistance, there is no common therapeutic strategy for HCV-associated insulin resistance. Indeed, treatments with exogenous insulin or sulfonylureas may be rather harmful because these treatments are associated with the development of HCC in patients with HCV infection. Meanwhile, we, along with others, have found distinctive treatments which improve HCV-associated insulin resistance. Administration of branched-chain amino acids (BCAA), especially as a late evening snack, improves glucose metabolism by improving insulin-signal cascades in insulin resistance patients with HCV infection. In this paper, we discuss the pathogenesis and complications for HCV-associated insulin resistance and further review a recent clinical therapeutic strategy using these agents for the treatment of this devastating disorder. We also discuss therapeutic potentialities of incretin-based therapies, new anti-diabetic agents for HCV-associated insulin resistance and the significance of insulin resistance in the era of new anti-viral treatments.
Biogas from lignocellulosic biomass : interest of pretreatments (2011)

International audience
Fiber Evolution during Alkaline Treatment and Its Impact on Handsheet Properties (2018)

&nbsp;To understand the swelling effects of alkaline treatment on the morphological properties of fibers and physical properties of handsheets, bleached softwood kraft pulp was treated with NaOH at different concentrations. The results showed that the fiber swelling increased, but the shrinkage and elongation of the paper at a NaOH concentration of 6% or higher did not improve. Dissolution of amorphous material occurred during the treatment together with peeling reactions. The fiber length and shape factor decreased and the fines content increased with an increasing alkali concentration. The cellulose crystallinity decreased with an increasing NaOH concentration. This was confirmed by X-ray diffractometry, which also showed that some cellulose I was converted to cellulose II, especially at higher NaOH concentrations (&gt; 9%). The fiber curl and kink indices increased and the handsheet density decreased with an increasing NaOH concentration. However, the tensile index decreased more steeply than the density with an increasing NaOH concentration, possibly because of the lower number and strength of the interfiber bonds, increased kinks, and reduced fiber strength and length. The handsheet extensibility first increased and subsequently decreased as the NaOH concentration increased, which indicated that well-controlled NaOH treatment could be used to improve the extensibility of paper.
Near-Optimal Pricing and Replenishment Strategies for a Retail/Distribution System (2001)

This paper integrates pricing and replenishment decisions for the following prototypical two-echelon distribution system with deterministic demands. A supplier distributes a single product to multiple retailers, who in turn sell it to consumers. The retailers serve geographically dispersed, heterogeneous markets. The demand in each retail market arrives continuously at a constant rate, which is a general decreasing function of the retail price in the market. The supplier replenishes its inventory through orders (purchases, production runs) from a source with ample capacity. The retailers replenish their inventories from the supplier. We develop efficient algorithms to determine optimal pricing and replenishment strategies for the following three channel structures. The first is the vertically integrated channel, where the system-wide pricing and replenishment strategies are determined by a central planner whose objective is to maximize the system-wide profits. The second structure is that of a vertically integrated channel in which pricing and operational decisions are made sequentially by separate functional departments. The third channel structure is decentralized, i.e., the supplier and the retailers are independent, profit-maximizing firms with the supplier acting as a Stackelberg game leader. We apply our algorithms to a set of numerical examples to quantify the supply chain inefficiencies due to functional segregation or uncoordinated decision making in a decentralized channel. We also gain insight into systematic differences in the associated pricing and operational patterns.
“I’ll be back”: Examining Restored Accounts On Twitter (2021)

Online social networks like Twitter actively monitor their platform to identify accounts that go against their rules. Twitter enforces account level moderation, i.e. suspension of a Twitter account in severe cases of platform abuse. A point of note is that these suspensions are sometimes temporary and even incorrect. Twitter provides a redressal mechanism to ‘restore’ suspended accounts. We refer to all suspended accounts who later have their suspension reversed as ‘restored accounts’. In this paper, we release the first-ever dataset and methodology 1 to identify restored accounts. We inspect account properties and tweets of these restored accounts to get key insights into the effects of suspension. We build a prediction model to classify an account into normal, suspended or restored. We use SHAP values to interpret this model and identify important features. SHAP (SHapley Additive exPlanations) is a method to explain individual predictions. We show that profile features like date of account creation and the ratio of retweets to total tweets are more important than content-based features like sentiment scores and Ekman emotion scores when it comes to classification of an account as normal, suspended or restored. We investigate restored accounts further in the pre-suspension and post-restoration phases. We see that the number of tweets per account drop by 53.95% in the post-restoration phase, signifying less ‘spammy’ behaviour after reversal of suspension. However, there was no substantial difference in the content of the tweets posted in the pre-suspension and post-restoration phases.
A polymorphism in the gene for the angiotensin II type 1 receptor is not associated with hypertension (1997)

We detected no association of the AT1 receptor polymorphism with hypertension, but a trend towards a decreased prevalence of the 1166C allele among hypertensive patients with a late age at diagnosis (> or = 50 years) was observed.