gebhart/patrepeval huggingface dataset:
Optical Data Processing with Bacteriorhodopsin and its Genetically Modified Variants (1992)

Abstract With Bacteriorhodopsin (BR) it will be demonstrated that biological systems - optimized by nature under evolutionary conditions - can be applied with great success to solve material requirements in technical systems. The possibility of genetic engineering further increases the technical applicability of these systems. The application of BR and its variants as a molecular processing unit in optical data processing will be shown in several examples.
ChemInform Abstract: The First Application of Samarium(II) Diiodide for the Formation of Group 14 Element Catenates: Synthesis of Tri‐ or Poly‐Germanes and Polystannanes. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Lectin‐mediated targeting of liposomes to a model surface An ELISA method (1988)

Wheat germ agglutinin has been conjugated to the surfaces of sonicated phospholipid liposomes by reacting the protein derivatised with N-succinimidyl-S-acetylthioacetate (SATA) with the m-maleimidobenzoyl-N-hydroxysuccinimide (MBS) derivative of dipalmitoylphosphatidylethanolamine (DPPE) incorporated into the liposomal bilayers. The liposomes as characterised by photon correlation spectroscopy had a weight-average radius of 44 +/- 10 nm and the number of WGA molecules per liposome was in the range up to approx. 120. An ELISA method has been developed to assess the efficiency of targeting the conjugated liposomes to the antigenic determinants on a surface coated with glycophorin A (blood group B). For liposomes in which the degree of conjugation was controlled by varying the mol% DPPE-MBS from 3 to 27% targeting efficiency as assessed from the extent of inhibition of the ELISA increased by a factor of 10.
Some More Observations on the Unique Electrochemical Properties of Electrode–Monolayer–Nanoparticle Constructs (2010)

Physical and electrochemical properties of gold nanoparticle-based electrodes are highlighted. Polycrystalline gold electrodes are passivated by a self-assembled monolayer, then the immobilization of gold nanoparticles "switch on" the electrochemical reactivity of ruthenium. Herein, gap-mode Raman studies show that the location of the nanoparticles is on the top of the monolayer, meaning that the "switching on" cannot be attributed to a direct electrical contact between nanoparticles and the gold support. This "switching on" feature is also not affected by the size of the gold nanoparticles with a range of diameters between 4 and 67 nm. Further, the charge of the nanoparticles is investigated by grafting chemical groups onto the nanoparticles which is observed to alter the electron-transfer kinetics. The variation in rate constant however is insufficient to attribute the "switching on" phenomenon to a possible adsorption of the redox species onto the nanoparticles.
An Example for Synchronized Usage of Different Applications in the Classroom (2006)

In the given publication an example for synchronized usage of different applications in the classroom is presented. To create a vivid environment for PowerPoint-lead lectures, we combine different interactive displays and force separation of phases of creating new content and augmentation of existing content. We deal with synchronization issues that occur while presented content is stored for later retrieval and content is delivered from different applications. We extend a common presentation environment by a projector and an interactive whiteboard to support a large auditorium. Our setup is economical in terms of development costs. A small application was developed for the interactive whiteboard. The discussion of the presented scenario is based on an evaluation in a class with over 100 computer science students
Cannabidiol (CBD) reduces convulsive seizure frequency in Dravet syndrome: results of a multi-center, randomized, controlled trial (GWPCARE1) (CT.001) (2017)

Assess the effect of CBD added on to antiepileptic drug therapy for treatment of drug-resistant seizures in Dravet syndrome.
Characterization of the Naturally Occurring Oxacillinase ofAcinetobacter baumannii (2005)

A chromosomally encoded oxacillinase, OXA-69, was characterized from Acinetobacter baumannii AYE. beta-Lactamase OXA-69 shared 97% amino acid identity with the recently described OXA-51 enzyme of A. baumannii and 62 and 56% amino acid identity with the carbapenem-hydrolyzing oxacillinases OXA-24 and OXA-23, respectively. Biochemical characterization of the purified OXA-69 revealed a narrow-spectrum hydrolysis profile but including, at a low level, imipenem and meropenem. By PCR and sequencing bla(OXA-69)-like genes were identified in all A. baumannii strains tested (n = 12), suggesting that this oxacillinase is naturally occurring in that species.
AIDS vaccines. Are we ready for human efficacy trials? (1994)

Worldwide, the human immunodeficiency virus type 1 (HIV-1) has already infected 10 million to 15 million people. With an estimated 5000 to 10 000 new infections occurring each day, 30 million to 40 million people will be infected by the year 2000.<sup>1</sup>In developing countries, where more than 80% of new infections are occurring, the virus is predominantly transmitted heterosexually and is broadly dispersed in general populations. Vaccines that will prevent HIV-1 disease and abrogate virus transmission must be viewed as critical components of a comprehensive public health strategy designed to combat the acquired immunodeficiency syndrome (AIDS) and slow the global spread of HIV-1 infection. See also p 475. Although most effective viral vaccines are based on either live attenuated (eg, measles) or inactivated (eg, influenza) virus products, research strategies for HIV-1 vaccine development have focused primarily on the viral envelope glycoproteins gp 120 and gp 160. This focus
Copper complexes of the "tripod" ligand tris(2-benzimidazolylmethyl)amine: five- and six-coordinate copper(II) derivatives and some copper(I) derivatives (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCopper complexes of the "tripod" ligand tris(2-benzimidazolylmethyl)amine: five- and six-coordinate copper(II) derivatives and some copper(I) derivativesAnthony W. Addison, Hugo M. J. Hendriks, Jan Reedijk, and Laurence K. ThompsonCite this: Inorg. Chem. 1981, 20, 1, 103–110Publication Date (Print):January 1, 1981Publication History Published online1 May 2002Published inissue 1 January 1981https://pubs.acs.org/doi/10.1021/ic50215a024https://doi.org/10.1021/ic50215a024research-articleACS PublicationsRequest reuse permissionsArticle Views737Altmetric-Citations137LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Dynamics of the sleep EEG after an early evening nap: experimental data and simulations (1996)

Increasing sleep pressure is associated with highly predictable changes in the dynamics of the sleep electroencephalogram (EEG). To investigate whether the effects of reduced sleep pressure also can be accounted for by homeostatic mechanisms, nighttime sleep following an evening nap was recorded in healthy young men. In comparison with the baseline night, sleep latency in the postnap night was prolonged, rapid eye movement sleep (REMS) latency was reduced, and EEG power density in non-REMS was decreased in the delta and theta band. The buildup of both EEG slow-wave activity (SWA; power density in the 0.75-to 4.5-Hz range) and spindle frequency activity (SFA; power density in the 12.25-to 15.0-Hz range) in non-REMS episodes was diminished (SWA: episodes 1-3; SFA: episode 1). The typical declining trend of SWA over consecutive non-REM sleep episodes was attenuated. The time course of SWA could be closely simulated with a homeostatic model of sleep regulation, although some discrepancies in level and buildup of SWA were apparent. We conclude that homeostatic mechanisms can largely account for the dynamics of the sleep EEG under conditions of reduced sleep pressure.
Ankle-Foot Orthoses: Proprioceptive Inputs and Balance Implications (2010)

Individuals with a loss of sensation in the lower limbs frequently experience postural instability, altered gait patterns, and an increased risk of falling culminating in a decreased quality of life. Previous studies have documented that using ankle-foot orthoses (AFOs) help such individuals to maintain their balance. This study was conducted to investigate whether somatosensory cues delivered to the intact tissues of the lower limbs above the ankle joints enhance the control of posture in individuals with peripheral neuropathy. The study involved 12 individuals with sensory neuropathy because of diabetes who participated in static and dynamic balance tests with and without specially designed AFOs that provided auxiliary sensory cues to the lower limbs without stabilizing the ankle joints. During the tests, the subjects were required to alternately stand on a fixed and moving platform with their eyes alternately open or closed. Equilibrium scores and response latencies were obtained. The results showed that equilibrium scores were significantly higher in experiments with the specially modified AFOs compared with conditions without AFOs. Smaller latency scores were recorded in conditions with AFOs as well. The outcome indicates that AFOs that substitute for the lack of proprioceptive feedback may improve automatic postural responses in individuals with diabetic peripheral neuropathy. It also highlights the need for further research focused on the design of assistive means that could improve the balance and the performance of activities of daily living in individuals with proprioceptive deficits.
Soluble Low Density Lipoprotein Receptor-related Protein (LRP) Circulates in Human Plasma (1997)

Our studies have identified a soluble molecule in normal human plasma and serum with the characteristics of the alpha-chain of the low density lipoprotein receptor-related protein (LRP). LRP is a large multifunctional receptor mediating the clearance of diverse ligands, including selected lipoproteins, various protease inhibitor complexes, and thrombospondin. A soluble molecule (sLRP) has been isolated from plasma using an affinity matrix coupled with methylamine-activated alpha2-macroglobulin, the ligand uniquely recognized by LRP, and eluted with EDTA. This eluate contains a protein that co-migrates on SDS-polyacrylamide gel electrophoresis with authentic human placental LRP alpha-chain, is recognized by anti-LRP alpha-chain monoclonal antibodies, and binds the 39-kDa receptor-associated protein (RAP) and tissue plasminogen activator-inhibitor complexes. A similar RAP-binding molecule was detected in medium conditioned for 24 h by primary cultures of rat hepatocytes, suggesting that the liver may be the in vivo source of sLRP. In contrast, immunoprecipitation experiments failed to detect the production of sLRP by cultured HepG2 hepatoma and primary human fibroblast cells. Addition of a soluble form of LRP to cultured HepG2 cells resulted in a significant inhibition of capacity of these cells to degrade tPA, a process that has been demonstrated to be mediated by cell surface LRP. Preliminary data indicate that the concentration of sLRP is altered in the plasma of patients with liver disease. Increased levels of sLRP may antagonize the clearance of ligands by cell bound LRP perturbing diverse processes including lipid metabolism, cell migration and extracellular proteinase activity.
Mesosphere and Lower Thermosphere Winds and Tidal Variations During the 2019 Antarctic Sudden Stratospheric Warming (2022)

Abstract Realistic modeling of the winds and dynamical variations in the mesosphere and lower thermosphere (MLT) at Southern Hemisphere (SH) mid‐to‐high latitudes near 60°S where dramatic motions occur has been a challenge. This work presents an evaluation of the MLT zonal and meridional winds from ∼80 to 98 km altitude produced by the high‐altitude version of the Navy Global Environmental Model (NAVGEM‐HA) numerical weather prediction system during the Antarctic Sudden Stratospheric Warming (SSW) in September 2019. These results are compared with the coincident measurements by five meteor radars at Tierra del Fuego (TDF; 53.7°S, 67.7°W), King Edward Point (KEP; 54.3°S, 36.5°W), King Sejong Station (KSS; 62.2°S, 58.8°W), Rothera (ROT; 67.5°S, 68.0°W), and Davis (DAV; 68.6°S, 78.0°E) across SH mid‐to‐high latitudes. We find that the day‐to‐day variations in NAVGEM‐HA winds related to tidal motions are overall consistent with variations in the radar winds, and the daily mean winds have a correlation of 0.7–0.9 between them. Three‐hourly NAVGEM‐HA winds have a correlation of ∼0.5 and mean difference &lt;10 m/s to the radar observations at most stations, and the Root Mean Square (RMS) error ranges from ∼25 to 35 m/s. Above 90 km altitude, the correlation coefficient decreases, and the difference and RMS error increase, indicating an upper limit to the validity of the NAVGEM‐HA results. Both the analyzed and observed winds reveal an enhancement in diurnal and semidiurnal tidal amplitude during this SH SSW. NAVGEM‐HA shows some evidence that nonmigrating tidal enhancements are produced through the interaction of migrating tides with planetary waves.
Hyperlactatemia during cardiopulmonary bypass: determinants and impact on postoperative outcome (2006)

Hyperlactatemia during cardiopulmonary bypass appears to be related mainly to a condition of insufficient oxygen delivery (type A hyperlactatemia). During cardiopulmonary bypass, a careful coupling of pump flow and arterial oxygen content therefore seems mandatory to guarantee a sufficient oxygen supply to the peripheral tissues.
An Efficient Dimensional Reduction of the Blocking Matrix for the Multistage Wiener Filter (2007)

The multistage Wiener filter (MWF) is a powerful adaptive processing in low sample support environments. Because the MWF solution is provided by a stage-by-stage decomposition, the computational load increases depending on degrees-of-freedom (DOF). In this paper, we propose two efficient approaches by reducing dimensions of the blocking matrix. One approach is to delete some rows of the blocking matrix at the 1st stage, and following stages are calculated by the normal method. The second approach is to delete some rows at all stages consistently. Although the MWF adaptive process of the proposed approaches must be stopped at the optimum stage to avoid a performance degradation, it was solved by applying a simple stopping criterion based on a cross-correlation coefficient. The performance was evaluated by simulation examples, examining the effectiveness.
Development and Characterization of a Marek's Disease Transplantable Tumor (2016)

SUMMARY A serially transplantable Marek's disease (MD) tumor, designated MDCT-RP-3, was developed from an MD-virus-induced lymphoma (GA strain) in a pedigreed female chicken of the inbred Bhistocompatible (B2/B2), line 72, and is the first MD tumor transplant to be developed in chickens both syngeneic and selected for susceptibility to MD. The MDCT-RP-3 tumor maintained its female karyotype through at least 80 passages in male 72 chickens. High doses of tumor cells caused progressively growing tumors at 5 days postinoculation and death of young 72 chicks in 7-10 days, whereas allogeneic chicks of other lines were less susceptible. Tumors frequently regressed when doses of tumor cells were low or older chickens were used. MD virus was rescued from MDCTRP-3 cells in cell culture, and chickens surviving the early transplant response sometimes developed MD lymphomas. The tumor cells expressed MD-tumor-associated surface antigen (MATSA) and T-cell surface antigens. A serum raised in rabbits against MDCTRP-3 cells and absorbed with normal 72 cells appeared to be reactive against MATSA on all MD tumor cells tested and is probably monospecific. Sera raised against MDCT-RP-3 in chickens also contained MATSA antibodies reactive against heterologous but not homologous MD tumor cells. Protection against transplantation of MDCT-RP-3 cells was not afforded by immunization with turkey herpesvirus vaccine. Some unvaccinated chickens that regressed MDCT-RP-3 transplant appeared to be partially immune to later development of MD lymphomas.
UPDATING THE HRR COLOR VISION TEST. (2002)

Saturday, December 14, 2002: San Diego Convention Center: Room 11A: Vision Science Lectures: PDF Only
Web-Based Interactive Electronic Technical Manual (IETM) Common User Interface Style Guide, Version 2.0 (2003)

Abstract : The scope of this document is limited to addressing Interactive Electronic Technical Manuals (IETMs) likely being maintained in Standard Generalized Markup Language (SGML) or Extensible Markup Language (XML). These IETMs are to be viewed with a standard browser such as Microsoft's Internet Explorer or Netscape's Navigator and delivered to run under Advanced Technical Information Support (ATIS), an intra/internet, or a combination thereof.
Combining the outputs of functional models of organs responsible for binaural cue decoding (2013)

The binaural cue decoding in the human auditory pathway occurs in the medial superior olive (MSO) and the lateral superior olive (LSO). The MSO is sensitive to interaural time difference (ITD), whereas the LSO is sensitive to interaural level difference as well as to ITD at low frequencies. Functional models of such organs have been presented previously (V. Pulkki & T. Hirvonen, Acta Acoustica united with Acoustica 95, 883 - 900, 2009). However, the outputs of those models are not as such applicable as the level of the output varies for a point-like broadband stimulus depending on the frequency and between the models. Here, a method is presented to combine the outputs of such models and an additional model of the MSO designed to decode directional cues based on broadband envelope time-shifts between the ear canal signals. Applicable cues are obtained by mapping the outputs into azimuth direction values following the idea of self-calibration, and by favoring the cue values suggesting more lateral directions. Furthermore, it is shown how the resulting directional cues can be applied to form a binaural activity map, and that the activity map corresponds to the human perception in several scenarios of psychoacoustical experiments.
HIGH-FREQUENCY MONOSTATIC ECHOES FROM FINITE-LENGTH CYLINDERS (1990)

We study the scattering of plane monochromatic acoustic waves of frequency f by rigid, finite-length cylinders of various L/D-ratios, submerged in a fluid, at arbitrary incidence angles θ. The cylinder end-caps are either flat or hemispherical. The (monostatic) backscattering cross-sections are determined by the physical optics (P.O.) or Kirchhoff method, and in some instances by saddle-point techniques. The far-field scattered pressures as functions of θ are used to obtain target strength (TS) estimates in decibels. We derive the pertinent formulas and display the resulting TS as functions of θ and f in various relevant situations. We compare results for various terminations and by various methods. The results are valid down to relatively low frequencies.
Endocytic deficiency induced by intersectin-1s knockdown alters the Smad2/3-Erk1/2 signaling balance downstream of Alk5 (2015)

Recently, we demonstrated in cultured endothelial cells and in vivo that deficiency of an isoform of intersectin-1, ITSN-1s, impairs caveolae and clathrin-mediated endocytosis and functionally upregulates compensatory pathways and their morphological carriers (i.e. enlarged endocytic structures, membranous rings or tubules) that are normally underrepresented. We now show that these endocytic structures internalize the broadly expressed transforming growth factor β receptor I (TGFβ-RI or TGFBR1), also known as Alk5, leading to its ubiquitylation and degradation. Moreover, the apoptotic or activated vascular cells of the ITSN-1s-knockdown mice release Alk5-bearing microparticles to the systemic circulation. These interact with and transfer Alk5 to endocytosis-deficient endothelial cells, resulting in lung endothelial cell survival and phenotypic alteration towards proliferation through activation of Erk1 and Erk2 (also known as MAPK3 and MAPK1, respectively). We also show that non-productive assembly of the Alk5-Smad-SARA (Smad anchor for receptor activation, also known as ZFYVE9) signaling complex and preferential formation of the Alk5-mSos-Grb2 complex account for Erk1/2 activation downstream of Alk5 and proliferation of pulmonary endothelial cells. Taken together, our studies demonstrate a functional relationship between the intercellular transfer of Alk5 by microparticles and endothelial cell survival and proliferation, and define a novel molecular mechanism for TGFβ and Alk5-dependent Erk1/2(MAPK) signaling that is significant for proliferative signaling and abnormal growth.
Identification by a proteomic approach of a plasma protein as a possible biomarker of illicit dexamethasone treatment in veal calves (2014)

Corticosteroids have become the most widespread illegal growth promoters in veal calves and beef cattle. Testing for corticosteroids relies on either direct detection of compounds or their metabolites or indirect detection to identify changes in biological pathways. We used a comparative proteomic approach, based on two-dimensional electrophoresis (2DE), to identify plasma protein markers after short-term dexamethasone administration in veal calves. Twenty-three male Friesian veal calves were treated experimentally with dexamethasone sodium phosphate: 10 received low-dose administration of the drug (0.4 mg day⁻¹ per os) for 20 consecutive days (treatment group); 10 received the drug at therapeutic dosage (2-4 mg kg⁻¹ i.m.) for 3 consecutive days (comparison group). Three animals were not treated (control group). Plasma samples were collected from each animal at six time points (T1-T6; treatment and control group) and at four time points (T1-T4; comparison group) and stored at -80°C until analysis. Plasma proteins were quantified and analysed in triplicate by 2DE. The images were analysed with Bionumerics® software. Comparison of 2DE maps obtained from blood samples at T1 (before treatment) and at T6 (final sampling) showed a significant disappearance (p < 0.001) of two protein spots at T6 in the treatment group. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis and immunoblotting identified these isoforms as serum paraoxonase/arylesterase 1 precursor (PON1). Synthesised in the liver and released into the blood, PON1 has an important role in lipid metabolism. The absence of variation of this protein in the comparison group suggests that the marker has good specificity for detecting illicit corticosteroid treatment.