gebhart/patrepeval huggingface dataset:
Collaborative Frame Selection: Exact and Distributed Algorithms for a Networked Robotic Camera with Discrete Zoom Levels (2003)

Collaborative Frame Selection arises when one robotic pan, tilt, zoom camera is shared by many users. The problem is to compute optimal camera parameters based on simultaneous frame requests from all users. We formalize the problem using a new metric, Intersection Over Maximum (IOM), to model the degree of satisfaction for each user, and seek to maximize total satisfaction for n users. We assume the zoom parameter is chosen from a discrete set of m levels and consider cases with discrete and continuous pan and tilt paramters. For a discrete set of w h pan and tilt values, we give an exact algorithm that runs in O((n + mwh) log n). For continuous pan and tilt, we give an exact algorithm that runs in O(n m) time. We also give a distributed version that runs in O(nm) time at each client and in O(n log n+mn) time at the server. An implementation of the second algorithm can be found online at: http://www.tele-actor.net/sharecam/.
Production of Hematite Micro- and Nanoparticles in a Fluidized Bed Process—Mechanism Study (2019)

A continuous, compact and simple process was developed to synthesize micro- and nanoparticles of iron oxide. The process combines the spraying (pulverization) of an aqueous solution of iron nitrate in a fluidized bed reactor containing coarse and hot glass beads (T = 200 °C) for the production of solids and a transported bed reactor for calcination (T = 490 °C). The intermediate product formed in the fluidized bed reactor is 2-line ferrihydrite, while the calcination reactor allows the production of hematite micro- and nanoparticles. These particles are characterized by a narrow size distribution, a mean size of 0.5 μm, a specific surface area of 24 m2 g−1 and a density of 4499 kg m−3. Particles are made up of small clusters of crystallites having an average size of 47 nm and a low internal porosity (0.12). The reaction mechanism was studied using a muffle furnace and a lab convective dryer. It was found that several steps are involved leading first to the production of iron nitrate dihydrate after the removal of the solution water, as well as two and then five molecules of water of hydration. After that, the elimination of nitrate leads to the production of ferrihydrite. Finally, ferrihydrite is transformed into hematite due to the removal of residual nitrate and water of hydroxylation.
Nuclear factor-κB maintains TRAIL resistance in human pancreatic cancer cells (2006)

Although it displays promising activity in other tumor models, the effects of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) on human pancreatic cancer cells have not been comprehensively explored. We report that a majority of human pancreatic cancer cell lines (seven of nine) underwent apoptosis when they were exposed to recombinant human TRAIL in vitro. Characterization of surface TRAIL receptors by fluorescence-activated cell sorting showed that TRAIL-resistant cells (Panc-1 and HS766T) expressed lower levels of DR4 and DR5 than did TRAIL-sensitive cells. The proteasome inhibitor bortezomib (PS-341, Velcade) further increased TRAIL responsiveness in the TRAIL-sensitive cells and synergized with TRAIL to reverse resistance in Panc-1 and HS776T cells. The effects of bortezomib were mimicked by transfection with a small interfering RNA construct specific for the p65 subunit of nuclear factor-kappaB (NF-kappaB) or exposure to a selective chemical inhibitor of IKK (PS-1145). Silencing IkappaBalpha prevented TRAIL sensitization by PS-1145, confirming that IkappaBalpha mediated the effects of PS-1145. NF-kappaB inhibition resulted in down-regulation of BCL-XL and XIAP, and silencing either restored TRAIL sensitivity in TRAIL-resistant cells. Finally, therapy with TRAIL plus PS-1145 reversed TRAIL resistance in vivo to produce synergistic growth inhibition in orthotopic Panc-1 tumors. Together, our results show that NF-kappaB inhibits TRAIL-induced apoptosis in human pancreatic cancer cells and suggest that combination therapy with TRAIL and NF-kappaB inhibitors, such as bortezomib, PS-1145, or curcumin, should be considered as a possible treatment strategy in patients with pancreatic cancer.
The salt‐sensitivity in C57Bl/6J mice is linked to increased renal protein expressions of SLC4A4 and SLC4A5 (2019)

Background Renal regulation of sodium reabsorption largely depends on the function and protein expression of exchanger /transporters /channels for sodium and other ions along the nephron. Decreased protein expression of NCC mediated aldosterone‐escape, a reflection of pressure natriuresis phenomenon. However, the role of renal ion transporters in salt‐sensitive mice is not well understood. Therefore, we studied the effect of varying amounts of sodium intake on the blood pressure (BP) and renal expression of exchanger /transporters/channels for sodium and other ions in salt‐sensitive C57Bl/6J mice and salt‐resistant BALB/c mice. Methods Male C57BL6 and Balb/c mice were 3 months old, fed normal salt (0.6% NaCl, NS), low salt (&lt;0.02% NaCl, LS) and high salt (4% NaCl, HS) diet, respectively, for 1 week. The mice were placed in metabolic cages for 24 hr urine collection. BP was measured under anesthesia before sacrificing the mice. The kidneys were removed for immunoblotting and immunostaining. Data were analyzed with one‐way ANOVA, Holm‐Sidak test (P&lt;0.05 is significant). Results 4% NaCl diet increased the BP (ΔBP=+20 mm Hg) of C57Bl/6J (n=5) but not of sex‐and agematched BALB/c mice (n=5). Additional studies show that C57Bl/6J mice on high NaCl intake (1.6%, 4%, 6%) had higher BP (ΔBP=+20 mm Hg) relative to when they were on low or normal NaCl intake (&lt;0.09%, 0.6%, 0.8%). The dietary salt‐induced increase in BP was observed in anesthetized and conscious, un‐anesthetized mice, measured by telemetry. There were no differences in water/food intake, urinary excretion, and serum concentrations of Na+, K+, and Cl− between the two mouse strains. High salt intake increased the renal protein expressions of SLC4A5 (NBCe2) (162±8% vs. 100±5%) compared to normal salt diet in C57Bl/6J mice, which was not observed in BALB/c mice. High salt intake increased the renal protein expressions of SLC4A4 (NBC1) (163±12%) compared to normal salt diet in C57Bl/6J mice. By contrast, the 4% NaCl diet increased renal SLC26A6 (Pendrin L1) in both C57Bl/6J (190±1%) and BALB/c (161±8%) mice. Increased NaCl intake did not affect the renal protein expression of NHE3 in either mouse strain. Renal protein expressions of NCC and αENaC, but not of NKCC2 and γENaC, were decreased by high salt diet in BALB/c mice (normal response to HS intake), but not in C57Bl/6J mice. SLC4A5 was located in proximal tubules and distal convoluted tubules, colocalized with NHE3 and NCC respectively in the mouse renal cortex. We conclude that the salt‐sensitivity of BP of C57Bl/6J mice is associated with increased renal protein expressions of SLC4A4 and SLC4A5 and impaired salt‐mediated down‐regulation of NCC and αENaC. This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .
Contact Mechanism of Tribological Coatings With Columnar Microstructure (2008)

Tribological coatings for mechanical components such as bearings and gears can experience failure occurring at the surface for highly localized contact conditions. In the present study, a finite element analysis (FEA) model was developed to study the stress distribution and deformation of tungsten carbide reinforced amorphous hydrocarbon coatings with and without columnar microstructures under nanoindentation. Results show that the microstructure of these tribological coatings significantly influences the stress distribution and deformation under heavily loaded conditions.
Local Path Replanning for Unforeseen Obstacle Avoidance by Autonomous Sweeping Robots. (1999)

In this paper, we propose a planning algorithm for sweeping tasks in environments with unforeseen obstacles. Sweeping means a motion that a robot covers a 2-dimensional area. When a mobile robot finds an unforeseen obstacle, it has to not only avoid collision but also sweep the whole area including where the obstacle is located. In the proposed algorithm, a robot determines local area where sweeping path should be arranged based on it's limited sensing ability. The algorithm avoids heavy calculation cost by limiting the planning area. A robot minimizes length of path when it connects path inside and outside the local area. An autonomous mobile robot can omit running time by the algorithm. We verify the efficiency of the algorithm and discuss the trade-off between running time and sensing/calculation time by simulations and experiments.
Analytical study of a series of substituted (2,2'-bipyridyl)(pentamethylcyclopentadienyl)rhodium and -iridium complexes with regard to their effectiveness as redox catalysts for the indirect electrochemical and chemical reduction of NAD(P)+ (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAnalytical study of a series of substituted (2,2'-bipyridyl)(pentamethylcyclopentadienyl)rhodium and -iridium complexes with regard to their effectiveness as redox catalysts for the indirect electrochemical and chemical reduction of NAD(P)+Eberhard Steckhan, Sabine Herrmann, Romain Ruppert, Eva Dietz, Markus Frede, and Elke SpikaCite this: Organometallics 1991, 10, 5, 1568–1577Publication Date (Print):May 1, 1991Publication History Published online1 May 2002Published inissue 1 May 1991https://pubs.acs.org/doi/10.1021/om00051a056https://doi.org/10.1021/om00051a056research-articleACS PublicationsRequest reuse permissionsArticle Views1822Altmetric-Citations232LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A point mutation leads to altered product specificity in β-lactamase catalysis (1997)

beta-Lactamases are the primary cause of beta-lactam antibiotic resistance in many pathogenic organisms. The beta-lactamase catalytic mechanism has been shown to involve a covalent acyl-enzyme. Examination of the structure of the class A beta-lactamase from Bacillus licheniformis suggested that replacement of Asn-170 by leucine would disrupt the deacylation reaction by displacing the hydrolytic water molecule. When N170L beta-lactamase was reacted with penicillins, a novel product was formed. We postulate that with leucine at position 170 the acyl-enzyme undergoes deacylation by an intramolecular rearrangement (rather than hydrolysis) to form a thiazolidine-oxazolinone as the initial product. The oxazolinone subsequently undergoes rapid breakdown leading to the formation of N-phenylacetylglycine and N-formylpenicillamine. This appears to be the first reported case where a point mutation leads to a change in enzyme mechanism resulting in a substantially altered product, effectively changing the product specificity of beta-lactamase into that of D-Ala-D-Ala-carboxypeptidase interacting with benzylpenicillin.
Profiles of Global Gene Expression in Ionizing-Radiation–Damaged Human Diploid Fibroblasts Reveal Synchronization behind the G1 Checkpoint in a G0-like State of Quiescence (2020)

Cell cycle arrest and stereotypic transcriptional responses to DNA damage induced by ionizing radiation (IR) were quantified in telomerase-expressing human diploid fibroblasts. Analysis of cytotoxicity demonstrated that 1.5 Gy IR inactivated colony formation by 40–45% in three fibroblast lines; this dose was used in all subsequent analyses. Fibroblasts exhibited > 90% arrest of progression from G2 to M at 2 hr post-IR and a similarly severe arrest of progression from G1 to S at 6 and 12 hr post-IR. Normal rates of DNA synthesis and mitosis 6 and 12 hr post-IR caused the S and M compartments to empty by > 70% at 24 hr. Global gene expression was analyzed in IR-treated cells. A microarray analysis algorithm, EPIG, identified nine IR-responsive patterns of gene expression that were common to the three fibroblast lines, including a dominant p53-dependent G1 checkpoint response. Many p53 target genes, such as CDKN1A, GADD45, BTG2, and PLK3, were significantly up-regulated at 2 hr post-IR. Many genes whose expression is regulated by E2F family transcription factors, including CDK2, CCNE1, CDC6, CDC2, MCM2, were significantly down-regulated at 24 hr post-IR. Numerous genes that participate in DNA metabolism were also markedly repressed in arrested fibroblasts apparently as a result of cell synchronization behind the G1 checkpoint. However, cluster and principal component analyses of gene expression revealed a profile 24 hr post-IR with similarity to that of G0 growth quiescence. The results reveal a highly stereotypic pattern of response to IR in human diploid fibroblasts that reflects primarily synchronization behind the G1 checkpoint but with prominent induction of additional markers of G0 quiescence such as GAS1.
Clinical and pharmacokinetic comparison of cefuroxime sodium and cefuroxime lysine in the treatment of lower respiratory tract infections (1981)

Sixteen patients admitted to hospital with symptoms of lower respiratory infections were treated with cefuroxime, either the sodium salt (‘Zinacef’) or the lysine salt. Either complete resolution of signs and symptoms, or a marked improvement, was noted in 13 of the patients. Infecting organisms were usually rapidly eliminated and sputum purulence dramatically reduced by the second day following the initiation of treatment. A cross-over study in the patients showed that the pharmacokinetic behaviour of the lysine salt was similar to that of sodium cefuroxime, in both sputum and plasma. One patient receiving the sodium salt withdrew because of pain on injection. The cross-over study suggested that the lysine salt was less painful than the sodium salt.
Slurry Design Considerations for Mechanically Enhanced Cement Systems (2008)

Cement designs, notwithstanding ultimate compressive strength, have focused solely on properties during the liquid state. For years measurements such as thickening time, rheologies, fluid loss, etc. have helped the industry determine the competency of the slurry to help ensure a “successful” cement job. More recently, an increased effort to design cement systems past the fluid state and focus on the hardened cements properties has been observed. This has been aided in increased laboratory techniques and mathematical analysis. It is often found that two modifications can be made to a cement sheath’s mechanical response to defend against failure: 1) manipulation of the cements mechanical properties (i.e. adding elastomers to decrease Young’s modulus) or 2) increasing tolerance to failure (i.e., adding fibrous materials to increase the point of tensile failure). The new designs being proposed today for their mechanical response are best illustrated by a double-edged sword. On one edge, the designer accounts for the mechanical properties of the cement. Additives are used to adjust the properties to the desired mechanical properties. On the other edge, the added particulate loading can have an adverse effect on the slurry design and placement. The amount of solids added can compromise the solid to liquid ratio such that the cement’s rheologies become high. The increased rheologies can lead to increased pressures such that the material cannot be placed or significantly reduced pump rates are required for placement. In addition, the specific gravity of these mechanical property modifiers can be drastically different than other material within the design. The variance in specific gravities can lead to non-homogeneous slurries if proper care is not taken. Today’s slurries should be designed such that the mechanical properties are improved while maintaining sufficient rheologies for proper placement and a stable slurry once placed within the wellbore. This paper will discuss design techniques and testing for improved slurry designs (rheological and mechanical).
Implementation of systolic algorithms using pipelined functional units (2002)

The authors present a method to implement systolic algorithms (SAs) using pipelined functional units (PFUs). This kind of unit makes it possible to improve the throughput of a processor because of the possibility of initiating a new operation before the previous one has been completed. The method permits transformation of a SA so that it can be efficiently executed using PFUs. The method is based on two temporal transformations (slowdown and retiming) and one spatial transformation (coalescing). The temporal transformations permit the modification of the SA in such a way that dependences established by the PFU are preserved. The spatial transformation improves the hardware utilization. The method was applied to 1-D SAs with data contraflow. To demonstrate the effectiveness of the method, the authors describe an efficient implementation of a non-time-homogeneous SA with data contraflow for QR decomposition.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A New High Strength Stainless Maraging Spring Steel with Isotropic Shaping Capability (2001)

No abstracts.
Supplementary Table S4 from Metabolomic, DNA Methylomic, and Transcriptomic Profiling of Suberoylanilide Hydroxamic Acid Effects on LPS-Exposed Lung Epithelial Cells (2023)

&lt;p&gt;Supplementary Table S4 shows the genes analyzed for significant differential expression in control vs. LPS and LPS vs. SAHA groups.&lt;/p&gt;
Registration of Alzheimer’s Disease in Taiwan (2013)

We have reported the updated status of AD in Taiwan through a UDS that will foster future collaboration among countries using UDS. The updated information of patients with AD and their informants will direct the future care of AD in Taiwan.
DECODE: Deep Confidence Network for Robust Image Classification (2019)

Recent years have witnessed the success of deep convolutional neural networks for image classification and many related tasks. It should be pointed out that the existing training strategies assume that there is a clean dataset for model learning. In elaborately constructed benchmark datasets, deep network has yielded promising performance under the assumption. However, in real-world applications, it is burdensome and expensive to collect sufficient clean training samples. On the other hand, collecting noisy labeled samples is very economical and practical, especially with the rapidly increasing amount of visual data in the web. Unfortunately, the accuracy of current deep models may drop dramatically even with 5%-10% label noise. Therefore, enabling label noise resistant classification has become a crucial issue in the data driven deep learning approaches. In this paper, we propose a DEep COnfiDEnce network (DECODE) to address this issue. In particular, based on the distribution of mislabeled data, we adopt a confidence evaluation module that is able to determine the confidence that a sample is mislabeled. With the confidence, we further use a weighting strategy to assign different weights to different samples so that the model pays less attention to low confidence data, which is more likely to be noise. In this way, the deep model is more robust to label noise. DECODE is designed to be general, such that it can be easily combined with existing studies. We conduct extensive experiments on several datasets, and the results validate that DECODE can improve the accuracy of deep models trained with noisy data.
Selectivity of Dicamba in Wheat and Wild Buckwheat (1971)

The uptake, translocation, and fate of 14 C-labeled 3,6-dichloro- o -anisic acid ( 14 C-dicamba) were studied in wheat ( Triticum aestivum L., 'Selkirk’) and wild buckwheat ( Polygonum convolvulus L.) as resistant and susceptible species, respectively. Selectivity could not be explained by interspecific differences in uptake of 14 C-dicamba by leaf sections submerged in exogenous solutions. 14 C-dicamba accumulated in meristems of wild buckwheat but not in the youngest tillers of wheat. Moreover, wheat main culms conjugated or metabolized 14 C-dicamba more quickly than did wild buckwheat meristems. Therefore, selectivity of dicamba apparently was related to interspecific differences in translocation and metabolism.
Influence of the Major Histocompatability Complex on Disease Resistance and Productivity (1987)

Publications in which chickens of different B haplotypes were studied for differences in disease resistance or productivity traits are reviewed. The most prominent effects on diseases are those involving tumors, but other examples involving autoimmune disease and microbial infections not resulting in neoplasia or autoimmunity are also cited. Each referenced disease paper is briefly defined with regard to: population used, B alleles present, and the most resistant B types. Studies citing B haplotype influences on productivity and reproductive fitness traits are summarized and the most desirable B genes in each referenced population are given. Plausible mechanisms of the B haplotype's influence on the traits are briefly discussed. Based on the evidence reviewed for disease resistance and productivity traits and the central role of B-complex genes in immune function, it is concluded that poultry breeders should develop B-genotype information in their base breeding populations and use those types yielding optimal performance.
Characterization and directed evolution of a methyl-binding domain protein for high-sensitivity DNA methylation analysis (2015)

Methyl-binding domain (MBD) family proteins specifically bind double-stranded, methylated DNA which makes them useful for DNA methylation analysis. We displayed three of the core members MBD1, MBD2 and MBD4 on the surface of Saccharomyces cerevisiae cells. Using the yeast display platform, we determined the equilibrium dissociation constant of human MBD2 (hMBD2) to be 5.9 ± 1.3 nM for binding to singly methylated DNA. The measured affinity for DNA with two methylated sites varied with the distance between the sites. We further used the yeast display platform to evolve the hMBD2 protein for improved binding affinity. Affecting five amino acid substitutions doubled the affinity of the wild-type protein to 3.1 ± 1.0 nM. The most prevalent of these mutations, K161R, occurs away from the DNA-binding site and bridges the N- and C-termini of the protein by forming a new hydrogen bond. The F208Y and L170R mutations added new non-covalent interactions with the bound DNA strand. We finally concatenated the high-affinity MBD variant and expressed it in Escherichia coli as a green fluorescent protein fusion. Concatenating the protein from 1× to 3× improved binding 6-fold for an interfacial binding application.