gebhart/patrepeval huggingface dataset:
IL-23R–activated STAT3/STAT4 is essential for Th1/Th17-mediated CNS autoimmunity (2017)

The factors that promote the differentiation of pathogenic T cells in autoimmune diseases are poorly defined. Use of genetically modified mice has provided insight into molecules necessary for the development of autoimmunity, but the sum of the data has led to contradictory observations based on what is currently known about specific molecules in specific signaling pathways. To define the minimum signals required for development of encephalitogenic T cells that cause CNS autoimmunity, myelin-specific T cells were differentiated with various cytokine cocktails, and pathogenicity was determined by transfer into mice. IL-6+IL-23 or IL-12+IL-23 generated encephalitogenic T cells and recapitulated the essential cytokine signals provided by antigen-presenting cells, and both IL-6 and IL-12 induced IL-23 receptor expression on both mouse and human naive T cells. IL-23 signaled through both STAT3 and STAT4, and disruption in STAT4 signaling impaired CNS autoimmunity independent of IL-12. These data explain why IL-12-deficient mice develop CNS autoimmunity, while STAT4-deficient mice are resistant. CD4+ memory T cells from multiple sclerosis patients had significantly higher levels of p-STAT3/p-STAT4, and p-STAT3/p-STAT4 heterodimers were observed upon IL-23 signaling, suggesting that p-STAT3/p-STAT4 induced by IL-23 signaling orchestrate the generation of pathogenic T cells in CNS autoimmunity, regardless of Th1 or Th17 phenotype.
Ear-Canal Wideband Acoustic Transfer Functions of Adults and Two- to Nine-Month-Old Infants (2010)

Age-graded norms are essential to the successful clinical application of WATF. However, the effects of gender and laterality on the WATF are small.
A DEVICE FOR EVALUATING MELT/FLOW CHARACTERISTICS OF CHEESES (1998)

ABSTRACT A device to objectively measure the melt/flow behavior of cheeses at different temperatures was built consisting of a temperature‐controlled heater, an LVDT (linear variable differential transformer), and a personal computer with a data acquisition system. This device, named UW Meltmeter, operates in the lubricated squeeze‐flow configuration and can be used either alone at a constant force or in conjunction with a universal testing machine at a constant deformation rate. A marker technique was used to verify the shear‐free squeezing flow assumption. The flow of Mozzarella cheeses with 14 and 43% fat content was studied at 40 and 60C under constant force (0.7 and 0.9 N) and constant cross‐head speed (0.5 and 2.5 cm/min). Biaxial extensional strain rate and biaxial stress growth coefficient were calculated. The results supported the expected trend of increased meltability at higher fat levels and at higher temperatures.
Triggeringand dynamic evolution ofthe LUSImudvolcano,Indonesia (2007)

AbstractMudvolcanoesaregeologicallyimportantmanifestationsofverticalfluidflowandmuderuption insedimentarybasinsworldwide.Theirformationispredominantlyascribedtoreleaseofoverpressurefromclay-andorganic-richsediments,leadingtoimpressivebuild-up of mud mountains in submarine and subaerial settings. Here we report on a newly born mud volcano appearing close to an activemagmaticcomplexinabackarcsedimentarybasininIndonesia.Thelocationofthemudvolcanoclosetomagmaticvolcanoesresultsinahigh background temperature gradient that triggers mineralogical transformations and geochemical reactions at shallow depth. Theeruption of 100 °C mud and gas that started the 29th of May 2006 flooded a large area within the Sidoarjo village in Northeast Java.Thousandsofpeoplehavesofarbeenevacuatedduetothemudfloodhazardsfromtheeruption.Sincetheinitialeruption,theflowrateescalatedfrom5000to120,000m 3 /dduringthefirstelevenweeks.Thentheeruptedvolumestartedtopulsatebetweenalmostzeroand120,000m 3 /dintheperiodAugust14toSeptember10,whereasitincreaseddramaticallyfollowingswarmsofearthquakesinSeptember,beforereaching almost180,000m
Combination of Capillary Zone Electrophoresis-Mass Spectrometry, Ion Mobility-Mass Spectrometry, and Theoretical Calculations for Cysteine Connectivity Identification in Peptides Bearing Two Intramolecular Disulfide Bonds (2019)

Disulfide bonds between cysteine residues are commonly involved in the stability of numerous peptides and proteins and are crucial for providing biological activities. In such peptides, the appropriate cysteine connectivity ensures the proper conformation allowing an efficient binding to their molecular targets. Disulfide bond connectivity characterization is still challenging and is a critical issue in the analysis of structured peptides/proteins targeting pharmaceutical or pharmacological utilizations. This study describes the development of new and fast gas-phase and in-solution electrophoretic methods coupled to mass spectrometry to characterize the cysteine connectivity of disulfide bonds. For this purpose, disulfide isomers of three peptides bearing two intramolecular disulfide bonds but different cysteine connectivity have been investigated. Capillary zone electrophoresis and ion mobility both coupled to mass spectrometry were used to perform the separation in both aqueous and gas phases, respectively. The separation efficiency of each technique has been critically evaluated and compared. Finally, theoretical calculations were performed to support and explain the experimental data based on the predicted physicochemical properties of the different peptides.
Divalent metal ion requirements of a thermostable multimetal beta-galactosidase from Saccharopolyspora rectivirgula. (1994)

To understand the roles of metal ions on the catalytic properties and thermostability of the thermostable beta-galactosidase of Saccharopolyspora rectivirgula, a thermophilic actinomycete, we have investigated the binding kinetics and requirements of divalent metal ions by equilibrium dialysis, titration, and metal ion buffer techniques. We found that the monomeric multimetal enzyme (M(r) 136,977) had eight specific binding sites for divalent metal ions. These sites were classified as follows: a very tight (class I) site for Ca2+, three tight (class II) sites consisting of two Ca(2+)-specific sites (class IICa) and one Mn(2+)-specific site (class IIMn; Kd for Mn2+, 2.0 nM), and four loose (class III) sites for Mn2+ (Kd, 1.2 microM) and Mg2+ (Kd, 2 microM). Removal of metal ions bound to class II and III sites of the holoenzyme (Ca3Mn5 species; relative Vmax (Vrel), 100%) by a chelating resin at 4 degrees C yielded a less thermostable Ca1 species (Vrel, 1.7%) with a class I Ca2+ ion, removal of which by a chelating resin at 50 degrees C caused a complete irreversible inactivation of the enzyme. Titration studies revealed that stoichiometric binding of Mn2+ to a class IIMn site of the Ca1 species caused a 33-fold activation whereas binding of Ca2+ to class IICa sites had no effect on enzyme activity. Ca1 species could be also activated 8-fold by heating at 60 degrees C for 20 min, suggesting that the catalytically important class II Mn2+ plays important roles in maintaining the native structure essential for activity. Occupation of class III sites by Mg2+ or Mn2+ was of physiological importance to attain sufficient thermostability by which this extracellular beta-galactosidase remained active for a prolonged time at elevated temperatures as was observed during growth of S. rectivirgula.
ChemInform Abstract: Use of Formic or Oxalic Acid for the Regioselective Hydrocarboxylation of Alkenes and Alkynes Catalyzed by Pd/C and 1,4‐Bis(diphenylphosphino) butane. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Treatment of wide-necked bifurcation aneurysms with the eCLIPs device: 5-year experience of a single center (2022)

Our series demonstrates occlusion rates that are similar to those of standard stent-assisted coiling and intrasaccular flow diversion for wide-necked bifurcation aneurysms. Larger registry-based studies are necessary to support our findings.
ChemInform Abstract: SYNTH. UND STABILITAET VON THIAMIN‐MONOGLUTAMAT (1970)

Abstract Zur Darstellung eines salzfreien Thiamin‐monoglutamats (I) wurde eine Lösung von Thiaminsulfat mit dem Bariumsalz der L‐Glutaminsäure versetzt, das ausgefällte Bariumsulfat abfiltriert und das Filtrat im Vakuum bis zur Kristallisation eingeengt.Das Salz (I) wird als ′Pentahydrat erhalten.
SI2-SSI: A Sustainable Infrastructure for Performance, Security, and Correctness Tools (2017)

Properties of software for computational science, data analysis, and connectivity cannot be understood without accounting for the characteristics and<br>behavior of the actual binary code. This project will overhaul, integrate, and enhance static binary analysis and runtime technologies to produce<br>components that provide a foundation for performance, correctness, and security tools that operate on software at the binary level.
General trends in the development of +-400 kV to +-1200 kV HVDC systems and areas of application (1976)

General trends in the development of hvdc systems are discussed, with specific reference to actual projects as indicators of such trends. Present systems rated +-250 kV to +-400 kV and potential future projects rated up to +-1200 kV are considered. Signigicant improvements achieved in both equipment design and system design concepts have had and will continue to have a very real impact on such trends and these improvements are also discussed.
ChemInform Abstract: MICROBIOLOGICAL HYDROXYLATION PART 15, HYDROXYLATION IN THE TERMINAL RINGS OF MONO‐ AND DI‐OXYGENATED 5ALPHA‐ANDROSTANES WITH THE FUNGUS DAEDALEA RUFESCENS (1975)

Abstract Aus Soz‐Androstan dargestellte Mono‐ und Diketone, sowie Ketoalkohole werden mit ′ Daedalea rufescens (D. r.) in 4‐6 Tagen hydroxyliert.
Intransigence in Negotiations: The Dynamics of Disagreement (1992)

Three-party negotiations are analyzed in which the players are able not only to rank alternatives but also have a preference for impasse. In a dynamic model, players progressively invoke fallback positions to try to prevent inferior outcomes from being implemented in a game of incomplete information. A player's intransigence, or unwillingness to retreat to fallback positions, generally works to his or her advantage. Greater size—or, equivalently, an enhanced ability to effect preferred outcomes—also helps, but intransigence is a potent force by itself. In fact, intransigence may prevail despite the fact that there is a so-called Condorcet alternative that could defeat it and all other alternatives. The analysis illuminates the rational basis of disagreement and why it develops in the manner it does. Extensions of the dynamic model are discussed, including making the preferences of the players for impasse endogenous.
The Constitution of Sponges (1926)

Research Article| January 01 1926 The Constitution of Sponges: The Common Bath Sponge, Hippospongia equina Vernon James Clancey Vernon James Clancey Search for other works by this author on: This Site PubMed Google Scholar Biochem J (1926) 20 (6): 1186–1189. https://doi.org/10.1042/bj0201186 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation Vernon James Clancey; The Constitution of Sponges: The Common Bath Sponge, Hippospongia equina. Biochem J 1 January 1926; 20 (6): 1186–1189. doi: https://doi.org/10.1042/bj0201186 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Journal Search Advanced Search This content is only available as a PDF. © 1926 CAMBRIDGE UNIVERSITY PRESS1926 Article PDF first page preview Close Modal You do not currently have access to this content.
Chromosome Structure as Revealed by a Combined Chemical and Immunochemical Procedure (1973)

Human metaphase chromosomes were photooxidized in the presence of methylene blue, a process that destroys guanine residues in DNA. Indirect immunofluorescence showed that such chromosomes reacted with a cytosine-specific antibody revealing a consistent fluorescent banding pattern by which each chromosome could be identified. The observed fluorescent patterns were the reverse of those produced in formamide-denatured chromosomes treated with an antibody specific for adenine and of the patterns obtained with quinacrine and with Giemsa staining by the G-banding techniques. The patterns were identical to Giemsa R-banding patterns. The chromosome banding patterns, therefore, appeared to reflect DNA base composition, indicating the feasibility of a combined chemical-immunochemical investigation of the chemical organization of chromosomes.
Enantioselective allylation of Grignard reagents with nickel-diphosphine catalysts (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnantioselective allylation of Grignard reagents with nickel-diphosphine catalystsGiambattista Consiglio and Adriano IndoleseCite this: Organometallics 1991, 10, 10, 3425–3427Publication Date (Print):October 1, 1991Publication History Published online1 May 2002Published inissue 1 October 1991https://doi.org/10.1021/om00056a007RIGHTS & PERMISSIONSArticle Views349Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (361 KB) Get e-Alerts Get e-Alerts
Ageing with HIV: Challenges and biomarkers (2022)

The antiretroviral treatment (ART) developed to control HIV infection led to a revolution in the prognosis of people living with HIV (PLWH). PLWH underwent from suffering severe disease and often fatal complications at young ages to having a chronic condition and a life expectancy close to the general population. Nevertheless, chronic age-related diseases increase as PLWH age. The harmful effect of HIV infection on the individual's immune system adds to its deterioration during ageing, exacerbating comorbidities. In addition, PLWH are more exposed to risk factors affecting ageing, such as coinfections or harmful lifestyles. The ART initiation reverses the biological ageing process but only partially, and additionally can have some toxicities that influence ageing. Observational studies suggest premature ageing in PLWH. Therefore, there is considerable interest in the early prediction of unhealthy ageing through validated biomarkers, easy to implement in HIV-clinical settings. The most promising biomarkers are second-generation epigenetic clocks and integrative algorithms.
Mobile RF Scenario Design for Massive-Scale Wireless Channel Emulators (2023)

Large-scale wireless emulation is gaining momen-tum nowadays, thanks to its potential in the development and deployment of advanced use cases for next-generation wireless networks. Several novel use cases are indeed emerging, including massive MIMO, millimeter wave beamforming and AI-based Vehicle-to-Everything (V2X) optimized communication. The de-velopment and testing of a wireless application, especially at a large scale and when dealing with mobile nodes, faces several challenges that cannot be solved by simulation frameworks alone. Thus, massive-scale channel emulators are emerging, enabling the emulation of realistic scenarios which leverage real hardware and radio signals. However, this is a complex task due to the lack of realistic scenarios based on real datasets. We thus propose a novel framework for the design and generation of channel emulation scenarios starting from real mobility traces, either generated by means of dedicated tools, or collected on the field. Our framework provides a practical way of generating mobility scenarios with vehicles, pedestrians, drones and other mobile entities. We detail all the steps foreseen by our framework, from the provision of the traces and radio parameters, to the generation of a matrix describing the delay and IQ samples for each time instant and node in the scenario. We also showcase the potentiality of our proposal by designing and creating a vehicular 5G scenario with 13 vehicles, starting from a recently-disclosed open dataset. This scenario is then validated on the Colosseum channel emulator, proving how our framework can provide an effective tool for large-scale wireless networking evaluation.
In Vitro Targeting of Avidin-Expressing Glioma Cells with Biotinylated Persistent Luminescence Nanoparticles (2012)

Far red emitting persistent luminescence nanoparticles (PLNP) were synthesized and functionalized with biotin to study their targeting ability toward biotin-binding proteins. First, the interaction of biotin-decorated PLNP with streptavidin, immobilized on a plate, was shown to be highly dependent on the presence of a PEG spacer between the surface of the nanoparticles and the biotin ligand. Second, interaction between biotin-PEG-PLNP and free neutravidin in solution was confirmed by fluorescence microscopy. Finally, in vitro binding study on BT4C cells expressing lodavin fusion protein, bearing the extracellular avidin moiety, showed that such biotin-covered PLNP could successfully be targeted to malignant glioma cells through a specific biotin-avidin interaction. The influence of nanoparticle core diameter, incubation time, and PLNP concentration on the efficiency of targeting is discussed.
Selfrec-Net: self-supervised deep learning approach for the reconstruction of Cherenkov-excited luminescence scanned tomography (2023)

As an emerging imaging technique, Cherenkov-excited luminescence scanned tomography (CELST) can recover a high-resolution 3D distribution of quantum emission fields within tissue using X-ray excitation for deep penetrance. However, its reconstruction is an ill-posed and under-conditioned inverse problem because of the diffuse optical emission signal. Deep learning based image reconstruction has shown very good potential for solving these types of problems, however they suffer from a lack of ground-truth image data to confirm when used with experimental data. To overcome this, a self-supervised network cascaded by a 3D reconstruction network and the forward model, termed Selfrec-Net, was proposed to perform CELST reconstruction. Under this framework, the boundary measurements are input to the network to reconstruct the distribution of the quantum field and the predicted measurements are subsequently obtained by feeding the reconstructed result to the forward model. The network was trained by minimizing the loss between the input measurements and the predicted measurements rather than the reconstructed distributions and the corresponding ground truths. Comparative experiments were carried out on both numerical simulations and physical phantoms. For singular luminescent targets, the results demonstrate the effectiveness and robustness of the proposed network, and comparable performance can be attained to a state-of-the-art deep supervised learning algorithm, where the accuracy of the emission yield and localization of the objects was far superior to iterative reconstruction methods. Reconstruction of multiple objects is still reasonable with high localization accuracy, although with limits to the emission yield accuracy as the distribution becomes more complex. Overall though the reconstruction of Selfrec-Net provides a self-supervised way to recover the location and emission yield of molecular distributions in murine model tissues.
15.6 Gb/s transmission over 1 km of next generation multimode fiber (2002)

We report on a 15.6 Gb/s transmission over 1 km of next generation multimode fiber. The short wavelength module used a SiGe bipolar VCSEL driver. The multimode fiber was almost ideal and had a total DMD (differential mode delay) width of only 0.056 ps/m.
Hemocytic Differentiation in Hemopoietic Organ of Bombyx mori Larvae (1998)

Bombyx mori L. (Lepidoptera: Bombycidae) larva was investigated with a transmission electron microscopy to determine hemocytic differentiation in the hemopoietic organ located in the prothorax. Three and/or four types of stem cells in compact islets of the organ were observed. Immatured hemocytes in loose islets of the organ were more differentiated and developed than in compact islets. Four types of hemocytes such as prohemocyte, plasmatocyte, granulocyte and oenocytoid were observed in loose islets. Each type of hemocyte was differentiated from each type of stem cell. However, none of spherulocyte was observed. Each type of hemocytes matured in loose islets was discharged into hemolymph by the tearing of acellular membrane covering the islets. These observation strongly suggests that the four kinds of hemocytes except for spherulocytes first appeared in islets and then moved to the region of loose islets in matured form. The more detailed pathway of hemocytic differentiation in B. mori was represented here.
Total and Gleason Grade 4/5 Cancer Volumes are Major Contributors of Human Kallikrein 2, Whereas Free Prostate Specific Antigen is Largely Contributed by Benign Gland Volume in Serum From Patients With Prostate Cancer or Benign Prostatic Biopsies (2003)

Large benign prostate gland volume affects fPSA more than tPSA in serum. In PCa hK2 more closely correlates with total cancer volume and high grade PCa volume compared with tPSA or fPSA.
Microdosimetry: An interdisciplinary approach (1997)

The Twelfth Symposium on Microdosimetry was held at Keble College, Oxford, September 29--October 4, 1996. The aim of the meeting was to provide a forum to bring together experts in physics, chemistry, molecular and cell biology and oncogenesis, with a common interest in understanding molecular mechanisms that can be gained from studies of the dependence of radiation effects on radiation quality, to advance the application of microdosimetry to other fields such as medicine, to promote and advance education and training in the field of radiation sciences. These proceedings contain a selection of review articles presented by keynote speakers, complemented by original contributions from participants reflecting the interdisciplinary nature of the field. The specific topics have been regrouped into sections to give the reader a more balanced view of that area. The topics are: Track structure and damage simulation; Chemical processes from radiation to DNA; Clustered DNA damage; Chromosome architecture and aberrations; Radiation quality and biological effectiveness; Risk extrapolation and cancer; Microdosimetry applied to radiotherapy; Microdistribution in tissues; Single particle effects; Proportional counter microdosimetry; and Nanodosimetric devices and other detectors. Separate abstracts for selected papers have been indexed for the Energy Science and Technology Database.