gebhart/patrepeval huggingface dataset:
Ucp3 expression and function:Studies in transgenic mice and human muscle (2001)

Conference Abstract| October 01 2001 Ucp3 expression and function:Studies in transgenic mice and human muscle M-E Harper; M-E Harper 1Department of Biochemistry, Microbiology and Immunology Search for other works by this author on: This Site PubMed Google Scholar R. Dent; R. Dent 2Department of Psychiatry, Faculty of Medicine, University of Ottawa, 451 Smyth Rd, Ottawa, Canada K1H 8M5. Search for other works by this author on: This Site PubMed Google Scholar V. Bezaire; V. Bezaire 1Department of Biochemistry, Microbiology and Immunology Search for other works by this author on: This Site PubMed Google Scholar A. Antoniou; A. Antoniou 1Department of Biochemistry, Microbiology and Immunology Search for other works by this author on: This Site PubMed Google Scholar A. Gauthier; A. Gauthier 1Department of Biochemistry, Microbiology and Immunology Search for other works by this author on: This Site PubMed Google Scholar S. Monemdjou; S. Monemdjou 1Department of Biochemistry, Microbiology and Immunology Search for other works by this author on: This Site PubMed Google Scholar R. McPherson R. McPherson 1Department of Biochemistry, Microbiology and Immunology Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (2001) 29 (5): A98. https://doi.org/10.1042/bst029a098a Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation M-E Harper, R. Dent, V. Bezaire, A. Antoniou, A. Gauthier, S. Monemdjou, R. McPherson; Ucp3 expression and function:Studies in transgenic mice and human muscle. Biochem Soc Trans 1 October 2001; 29 (5): A98. doi: https://doi.org/10.1042/bst029a098a Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 2001 Biochemical Society2001 Article PDF first page preview Close Modal You do not currently have access to this content.
ADVANCED VIDEOCONFERENCING SERVICES BASED ON WEBRTC (2012)

Lately, videoconference applications have experienced an evolution towards the World Wide Web. New technologies have given browsers real-time communications capabilities. In this context, WebRTC aims to provide this functionality by following and defining standards. Being a new effort, WebRTC still lacks advanced videoconferencing services such as session recording, media mixing and adjusting to varying network conditions. This paper analyzes these challenges and proposes an architecture based on a traditional communications entity, the Multipoint Control Unit or MCU as a solution.
Programmable Hash Functions in the Multilinear Setting. (2013)

Abstract. We adapt the concept of a programmable hash function (PHF, Crypto 2008) to a setting in which a multilinear map is available. This enables new PHFs with previously unachieved parameters. To demonstrate their usefulness, we show how our (standard-model) PHFs can replace random oracles in several well-known cryptographic constructions. Namely, we obtain standard-model versions of the Boneh-Franklin identity-based encryption scheme, the Boneh-Lynn-Shacham signature scheme, and the Sakai-Ohgishi-Kasahara identity-based noninteractive key exchange (ID-NIKE) scheme. The ID-NIKE scheme is the first scheme of its kind in the standard model. Our abstraction also allows to derive hierarchical versions of the above schemes in settings with multilinear maps. This in particular yields simple and efficient hierarchical generalizations of the BF, BLS, and SOK schemes. In the case of hierarchical ID-NIKE, ours is the first such scheme with full security, in either the random oracle model or the standard model. While our constructions are formulated with respect to a generic multilinear map, we also outline the necessary adaptations required for the recent “noisy ” multilinear map candidate due to Garg, Gentry, and Halevi.
The Advanced Virgo+ status (2023)

Abstract The gravitational wave detector Advanced Virgo+ is currently in the commissioning phase in view of the fourth Observing Run (O4). The major upgrades with respect to the Advanced Virgo configuration are the implementation of an additional recycling cavity, the Signal Recycling cavity (SRC), at the output of the interferometer to broaden the sensitivity band and the Frequency Dependent Squeezing (FDS) to reduce quantum noise at all frequencies. The main difference of the Advanced Virgo + detector with respect to the LIGO detectors is the presence of marginally stable recycling cavities, with respect to the stable recycling cavities present in the LIGO detectors, which increases the difficulties in controlling the interferometer in presence of defects (both thermal and cold defects). This work will focus on the interferometer commissioning, highlighting the control challenges to maintain the detector in the working point which maximizes the sensitivity and the duty cycle for scientific data taking.
Characteristics of signals originating near the lithium-diffused N+ contact of high purity germanium p-type point contact detectors (2021)

A study of signals originating near the lithium-diffused n+ contact of p-type point contact (PPC) high purity germanium detectors (HPGe) is presented. The transition region between the active germanium and the fully dead layer of the n+ contact is examined. Energy depositions in this transition region are shown to result in partial charge collection. This provides a mechanism for events with a well defined energy to contribute to the continuum of the energy spectrum at lower energies. A novel technique to quantify the contribution from this source of background is introduced. Experiments that operate germanium detectors with a very low energy threshold may benefit from the methods presented herein.
Transient Heat Transfer Experiments in a Linear Cascade via an Insertion Mechanism Using the Liquid Crystal Technique (1995)

An insertion mechanism for a linear cascade allowing the displacement of one measurement airfoil to conduct transient heat transfer experiments is introduced. A basic feature of the system is its capability to work in a continously running tunnel driven by a compressor at steady state conditions. The experiment is initiated by pulling the measurement airfoil very rapidly through the sidewalls of the cascade by means of a pneumatic cylinder. Heat transfer measurements were obtained on a turbine airfoil at different exit Mach numbers up to M=0.8 and exit Reynolds numbers up to Re=1.2E6. The transient liquid crystal method was used applying a digital image processing system capable of recording and storing the optical signal in real time. Comparisons were performed with measurements conducted in the same test facility using the naphthalene sublimation technique as well as thin film gauges. Calculations were made with a two-dimensional boundary layer code.
Preparation and properties of transparent cellulose hydrogels (2003)

Abstract Highly transparent cellulose hydrogels with physical crosslinkage were prepared from nonaqueous organic cellulose solutions and viscose by coagulating and regenerating cellulose in an aqueous solution containing a water‐miscible organic solvent. Nonaqueous organic cellulose solutions used were LiCl/dimethylacetamide, paraformaldehyde/dimethyl sulfoxide, and triethylammonium chloride/dimethyl sulfoxide. Preparation conditions and physical properties of the transparent cellulose hydrogels were studied. The transparency of the cellulose hydrogels depended on the composition of the aqueous solution containing the organic solvent. Furthermore, transparent cellulose hydrogels from viscose showed high tensile strength. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 90: 3020–3025, 2003
Solution-processed In2S3buffer layer for chalcopyrite thin film solar cells (2016)

We report a route to deposit In2S3 thin films from air-stable, low-cost molecular precursor inks for Cd-free buffer layers in chalcopyrite-based thin film solar cells. Different precursor compositions and processing conditions were studied to define a reproducible and robust process. By adjusting the ink properties, this method can be applied in different printing and coating techniques. Here we report on two techniques, namely spin-coating and inkjet printing. Active area efficiencies of 12.8% and 12.2% have been achieved for In2S3-buffered solar cells respectively, matching the performance of CdS-buffered cells prepared with the same batch of absorbers.
Control over emergence and alignment of transient blisters in thermo-responsive gels using hierarchically patterned substrates (2022)

Surfaces with tunable microscale textures are vital in a large variety of technological applications, including heat transfer, antifouling and adhesion. To facilitate such broad-scale use, there is a need to create surfaces that undergo reconfigurable changes in topology and thus, enable switchable functionality. To date, there is a relative dearth of methods for engineering surfaces that can be actuated to change topography over a range of length scales, and hence, form tunable hierarchically structured layers. Combining modeling and experiments, we design a geometrically patterned, thermo-responsive poly (<i>N</i>-isopropylacrylamide) gel film that undergoes controllable hierarchical changes in topology with changes in temperature. At the bottom, the film is covalently bound to a solid, curved substrate; at the top, the film encompasses longitudinal rectangular ridges that are oriented perpendicular to the underlying cylindrical curves. At temperatures below lower critical solution temperature (LCST), the swollen gel exhibits 3D variations in polymer density and thickness defined by the gel's top and bottom topography. As the temperature rises above LCST, the interplay between the upper ridges and lower curves in the gel drives non-uniform, directional solvent transport, the nucleation and propagation of a phase-separated higher-density skin layer, and the resulting pressure buildup within the film. These different, interacting kinetic processes lead to an instability, which produces transient microscopic blisters in the film. Through simulations, we show how tuning the width of the ridges modifies the propagation of a skin layer and creates localized pressure build-up points, which enables control over the emergence, distribution, and alignment of the microscopic blisters. Additionally, we provide a simple argument to predict the size of such microscopic features. Experiments confirm our predictions and further highlight how our computational model enables the rational design of topographical transitions in these tunable films. The development of actuatable, hierarchically structured films provides new routes for achieving switchable functionality in actuators, drug release systems and adhesives.
A simple model to help distinguish necrotizing fasciitis from nonnecrotizing soft tissue infection1 (2000)

Admission WBC greater than 15.4 x 10(9)/L and serum Na less than 135mmol/L are useful parameters that may help to distinguish NF from non-NF infection, particularly when classic "hard" signs of NF are absent.
Supplementary Table S6 from Long Noncoding RNA <i>SChLAP1</i> Forms a Growth-Promoting Complex with HNRNPL in Human Glioblastoma through Stabilization of ACTN4 and Activation of NF-κB Signaling (2023)

&lt;p&gt;Proteins binding with SChLAP1 sense and antisense&lt;/p&gt;
Introduction of a calibration line for composition determination of a binary alloy by Auger electron spectroscopy (quantitative formalism) (1979)

In a complete uniform solid solution of a binary alloy, a theoretical method for constructing a very quantitative calibration line for an AES experiment has been developed. In the method, the following are considered: (i) attenuation of a primary beam, (ii) the effects of backscattered electrons and forwardscattered electrons both from solute and base metals, and (iii) true escape lengths of any electrons. Results of calculations are applied for Ag-Au, Mo-W, and Be-Cu systems.
Instability of Incompatible Bilayered Soft Tissues and the Role of Interface Conditions (2019)

Mechanical stability analysis is instructive in explaining biological processes like morphogenesis, organogenesis, and pathogenesis of soft tissues. Consideration of the layered, residually stressed structure of tissues, requires accounting for the joint effects of interface conditions and layer incompatibility. This paper is concerned with the influence of imposed rate (incremental) interface conditions (RICs) on critical loads in soft tissues, within the context of linear bifurcation analysis. Aiming at simplicity, we analyze a model of bilayered isotropic hyperelastic (neo-Hookean) spherical shells with residual stresses generated by "shrink-fitting" two perfectly bonded layers with radial interfacial incompatibility. This setting allows a comparison between available, seemingly equivalent, interface conditions commonly used in the literature of layered media stability. We analytically determine the circumstances under which the interface conditions are equivalent or not, and numerically demonstrate significant differences between interface conditions with increasing level of layer incompatibility. Differences of more than tenfold in buckling and 30% in inflation instability critical loads are recorded using the different RICs. Contrasting instability characteristics are also revealed using the different RICs in the presence of incompatibility: inflation instability can occur before pressure maximum, and spontaneous instability may be excluded for thin shells. These findings are relevant to the growing body of stability studies of layered and residually stressed tissues. The impact of interface conditions on critical thresholds is significant in studies that use concepts of instability to draw conclusions about the normal development and the pathologies of tissues like arteries, esophagus, airways, and the brain.
Clinicopathological Features of and Risk Factors for Multiple Primary Melanomas (2005)

The incidence of MPM is increased in patients with a positive family history and/or dysplastic nevi. These patients should undergo intensive dermatologic screening and should consider genetic testing.
NSLS-II Injector Commissioning and Initial Operation (2015)

The injector for the National Synchrotron Light Source II storage ring consists of a 3 GeV booster synchrotron and a 200 MeV S-band linac. The linac was designed to produce either a single bunch with a charge of 0.5 nC of electrons or a train of bunches up to 300 ns long containing a total charge of 15 nC. The booster was designed to accelerate up to 15 nC each cycle. Linac commissioning was completed in April 2012. Booster commissioning was started in November 2013 and completed in March 2014. All of the significant design goals were satisfied including beam emittance, energy spread, and transport efficiency. While the maximum booster charge accelerated was only 10 nC this has proven to be more than sufficient for storage ring commissioning. The injector has operated reliably during storage ring operation since then. Results will be presented showing measurements of injector operating parameters achieved during commissioning and initial operation. Operating experience and reliability during the first year of NSLS-II operation will be discussed.
Experimental characterization of high-intensity focused airborne ultrasound fields (2020)

High-intensity focused airborne ultrasound fields are increasingly applied in various technical fields, for example, to generate haptic feedback during gesture interaction. Reliable measurement data of sound pressure levels are required to assess potential health hazards to users. Such ultrasound fields pose special challenges for a quantitative characterization. The high sound pressure levels in combination with the higher harmonics generated by nonlinear effects require both a high upper limit of the level linearity range and a wide bandwidth of the measuring chain. Furthermore, small wavelengths and the focusing result in spatially strongly varying sound fields. In the present case, a 40 kHz signal was focused on a single point using a transducer array. Different microphone types were investigated with respect to their suitability for measuring high-power airborne ultrasound fields. A spatial characterization of the ultrasound field in the focal region as well as around an artificial head in a simulated application situation was performed. The microphone measurements were supplemented by measuring the radiation force with a balance and were compared to an analytical model of the sound field distribution. The presented results can contribute to the improvement of measurement technology and support a first assessment of the exposure of potential users.
Systematic analysis of viral genes responsible for differential virulence between American and Australian West Nile virus strains (2015)

A variant Australian West Nile virus (WNV) strain, WNVNSW2011, emerged in 2011 causing an unprecedented outbreak of encephalitis in horses in south-eastern Australia. However, no human cases associated with this strain have yet been reported. Studies using mouse models for WNV pathogenesis showed that WNVNSW2011 was less virulent than the human-pathogenic American strain of WNV, New York 99 (WNVNY99). To identify viral genes and mutations responsible for the difference in virulence between WNVNSW2011 and WNVNY99 strains, we constructed chimeric viruses with substitution of large genomic regions coding for the structural genes, non-structural genes and untranslated regions, as well as seven individual non-structural gene chimeras, using a modified circular polymerase extension cloning method. Our results showed that the complete non-structural region of WNVNSW2011, when substituted with that of WNVNY99, significantly enhanced viral replication and the ability to suppress type I IFN response in cells, resulting in higher virulence in mice. Analysis of the individual non-structural gene chimeras showed a predominant contribution of WNVNY99 NS3 to increased virus replication and evasion of IFN response in cells, and to virulence in mice. Other WNVNY99 non-structural proteins (NS2A, NS4B and NS5) were shown to contribute to the modulation of IFN response. Thus a combination of non-structural proteins, likely NS2A, NS3, NS4B and NS5, is primarily responsible for the difference in virulence between WNVNSW2011 and WNVNY99 strains, and accumulative mutations within these proteins would likely be required for the Australian WNVNSW2011 strain to become significantly more virulent.
Subthalamic nucleus‐mediated excitotoxicity in parkinson's disease: A target for neuroprotection (1998)

Dopamine deficiency causes disinhibition and overactivity of the subthalamic nucleus (STN). Output neurons from the STN are excitatory and use glutamate as a neurotransmitter. They project to the external and internal segments of the globus pallidum (GPe and GPi), the substantia nigra pars reticulata (SNr), and the pedunculopontine nucleus (PPN). In addition, STN neurons provide excitatory innervation to dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc) that contain glutamate receptors. Stimulation of the STN induces bursting activity in SNc dopaminergic neurons. This raises the possibility that the disinhibition of STN neurons that occurs as a result of a dopamine lesion might induce excitotoxic damage in target structures, including the SNc. In addition, the reduction in complex I activity found in the nigra in Parkinson's disease (PD) may cause mitochondrial dysfunction and make SNc dopaminergic neurons vulnerable to even physiologic concentrations of glutamate. We postulate that the dopamine loss that occurs in PD produces augmented STN activity which, in turn, causes further damage to vulnerable dopaminergic neurons, thereby creating a scenario for an increasing cycle of neuronal loss in the SNc. In addition, STN overactivity could, in theory, cause damage to the GPi, SNr, and PPN and thereby account for the development of parkinsonian features that do not respond to levodopa in patients with advanced disease. This hypothesis suggests that pharmacologic or surgical therapies that reduce STN neuronal overactivity or block glutamate receptors in the SNc and other target structures might be neuroprotective and might slow or halt the progression of neurodegeneration in PD.
Antifungal Flavonoids from Hildegardia barteri (2005)

A new isoflavan, (3R)-6,2'-dihydroxy-7-methoxy-4',5'-methylenedioxyisoflavan, hildegardiol (1), and two known flavonoids, 2-hydroxymaackiain (2) and farrerol (3), were isolated from the antifungal root extract of Hildegardia barteri. The pterocarpan 2 was largely responsible for the observed antifungal activity.
Counter-Current Suspension Extraction Process of Lignocellulose in Biorefineries to Reach Low Water Consumption, High Extraction Yields, and Extract Concentrations (2021)

The processing of large quantities of water in biorefining processes can lead to immense costs for heating, evaporation, and wastewater disposal. These costs may prohibit the exploitation of alternative products, e.g., xylooligosaccharides from straw, which are regarded as too costly. A new counter-current extractions method is proposed that aims at low solvent (water) consumption, as well as high yields and extract concentrations. This process was evaluated with suspension extraction experiments with steam pretreated wheat straw and the process window analysis based on a mass balance for a washing and a leaching scenario. The latter was conducted with two other suspension extraction processes as a comparison. The equilibration time was found to be well below 10 min. While the suspension extraction with and without recycling need to be designed to achieve a high yield or a high concentration and low solvent consumption, the proposed extraction method can reach all three simultaneously. Thus, this new process is evaluated as a potential method to spare water and downstream costs and allow new processing pathways in second-generation biorefineries.
Characteristics of high gradient insulators for accelerator and high power flow applications (2002)

The high gradient insulator has been demonstrated to operate at levels comparable or better than special geometry or coated insulators. Some patented insulator configurations allow for sophisticated accelerator structures, high power flow interfaces, and microwave applications not previously possible. Sophisticated manufacturing techniques available at AlliedSignal FM&T made this development possible. Bipolar and high power flow applications are specially suited for present insulator designs. The insulator shows a beneficial effect when used under RF fields or RF structures. These insulators can be designed, to a first approximation, from simple electron flight path equations. With a model of surface flashover physics we completed a set of design calculations that include effects such as layer density and dielectric/metal thickness. Experimental data, obtained in the last few years of development, is presented and reviewed. Several insulator fabrication characteristics, indicating critical design parameters, are also presented.