gebhart/patrepeval huggingface dataset:
ChemInform Abstract: A NEW ROUTE TO PERFLUORINATED ETHERS (1985)

Abstract Partiell fluorierte Ether, die durch radikalische Addition von Ethem an perfluorierte Alkene und Cycloalkene erhalten werden, lassen sich mit CoF 3 in hoher Reinheit in die Perfluorether (IV) überführen.
High-frequency shape and albedo from shading using natural image statistics (2011)

We relax the long-held and problematic assumption in shape-from-shading (SFS) that albedo must be uniform or known, and address the problem of “shape and albedo from shading” (SAFS). Using models normally reserved for natural image statistics, we impose “naturalness” priors over the albedo and shape of a scene, which allows us to simultaneously recover the most likely albedo and shape that explain a single image. A simplification of our algorithm solves classic SFS, and our SAFS algorithm can solve the intrinsic image decomposition problem, as it solves a superset of that problem. We present results for SAFS, SFS, and intrinsic image decomposition on real lunar imagery from the Apollo missions, on our own pseudo-synthetic lunar dataset, and on a subset of the MIT Intrinsic Images dataset[15]. Our one unified technique appears to outperform the previous best individual algorithms for all three tasks. Our technique allows a coarse observation of shape (from a laser rangefinder or a stereo algorithm, etc) to be incorporated a priori. We demonstrate that even a small amount of low-frequency information dramatically improves performance, and motivate the usage of shading for high-frequency shape (and albedo) recovery.
User intent based recommendation for modern BI systems (2019)

Stocker de grandes quantites de donnees complexifie les interactions avec les systemes de Business Intelligence (BI). Les systemes de recommandation semblent un choix logique pour aider les utilisateurs dans leur analyse. Ils extraient des comportements de donnees historiques et suggerent des actions personnalisees, potentiellement redondantes, via des scores de similarite. La diversite est essentielle pour ameliorer la satisfaction des utilisateurs, d’ou l’interet particulier accorde aux recommandations complementaires. Nous avons etudie deux problemes concrets d’exploration de donnees en BI et proposons de decouvrir et exploiter les intentions utilisateur pour fournir deux recommandeurs de requete. Le premier, un recommandeur collaboratif reactif original base sur l’intention, recommande des sequences de requetes a l’utilisateur pour poursuivre son analyse. Le second propose proactivement un ensemble de requetes pour completer un rapport BI, en fonction di contexte utilisateur.
Linking the pressure dependency of elastic and electrical properties of porous rocks by a dual porosity model (2016)

A R Y Knowledge about the pressure dependency of elastic and electrical properties is important for a variety of geophysical applications. We present a technique to invert for the stiff and compliant porosity from velocity measurements made as a function of differential pressure on saturated sandstones. A dual porosity concept is used for dry rock compressibility and a squirt model is employed for the pressure and frequency dependent elastic properties of the rocks when saturated. The total porosity obtained from inversion shows satisfactory agreement with experimental results. The electrical cementation factor was determined using the inverted porosity in combination with measured electrical conductivity. It was found that cementation factor increased exponentially with increasing differential pressure during isostatic loading. Elastic compressibility, electrical cementation factor and electrical conductivity of the saturated rocks correlate linearly with compliant porosity, and electrical cementation factor and electrical conductivity exhibit linear correlations with elastic compressibility of the saturated rocks under loading. The results show that the dual porosity concept is sufficient to explain the pressure dependency of elastic, electrical and joint elastic-electrical properties of saturated porous sandstones.
An adverse outcome pathway for lung surfactant function inhibition leading to decreased lung function (2021)

Inhaled substances, such as consumer products, chemicals at the workplace, and nanoparticles, can affect the lung function in several ways. In this paper, we explore the adverse outcome pathway (AOP) that starts when inhaled substances that reach the alveoli inhibit the function of the lung surfactant, and leads to decreased lung function. Lung surfactant covers the inner surface of the alveoli, and regulates the surface tension at the air-liquid interface during breathing. The inhibition of the lung surfactant function leads to alveolar collapse because of the resulting high surface tension at the end of expiration. The collapsed alveoli can be re-opened by inspiration, but this re-opening causes shear stress on cells covering the alveoli. This can damage the alveolar-capillary membrane integrity, allowing blood components to enter the alveolar airspace. Blood components, such as albumin, can interact with the lung surfactant and further inhibit its function. The collapse of the alveoli is responsible for a decrease in the surface area available for blood oxygenation, and it reduces the volume of air that can be inhaled and exhaled. These different key events lead to decreased lung function, characterized by clinical signs of respiratory toxicity and reduced blood oxygenation. Here we present the weight of evidence that supports the AOP, and we give an overview of the methods available <i>in vitro</i> and <i>in vivo</i> to measure each key event of the pathway, and how this AOP can potentially be used in screening for inhalation toxicity.
Plastid chaperonin proteins Cpn60α and Cpn60β are required for plastid division in Arabidopsis thaliana (2009)

Our results suggest that both ptCpn60alpha and ptCpn60beta are required for the formation of a normal plastid division apparatus, as the prokaryotic counterparts are required for assembly of the cell division apparatus. Since moderate reduction of ptCpn60 levels impaired normal FtsZ ring formation but not import of FtsZ into plastids, it is suggested that the proper levels of ptCpn60 are required for folding of stromal plastid division proteins and/or regulation of FtsZ polymer dynamics.
Silica Supported Tetrabutylammonium Fluoride as a Catalyst for the Silylation of Carbonvl and Hydroxy Compounds with Ethyltrimethylsilylacetate (1989)

Abstract the use of silica supported tetrabutylammonium fluoride (TBAF-SiO2) as a non hygroscopic catalyst for silylating ketones and aldehydes with ethyltrimethylsilylacetate (ETSA) gives predominantly kinetic and Z silylenolethere at room temperature. TBAF-SiO2/ETSA is also useful in the silylation of alcohols.
Abstract 14176: Pulmonary Effective Artery Elastance as a Novel Predictor of Adverse Events in Patients With Pulmonary Embolism (2020)

Introduction: Risk stratification tools including the Pulmonary Embolism Severity Index (PESI) and BOVA rely on complicated calculations that give less attention to hemodynamic parameters predictive of cardiogenic shock in acute pulmonary embolism (PE). We explored the possibility that simultaneous measurement of right sided and left sided non-invasive hemodynamic parameters by echocardiography may predict adverse sequelae in the context of acute PE. Methods: We retrospectively reviewed all Pulmonary Embolism Response Team (PERT) activations between 2014 and 2020. The PESI and BOVA scores were calculated and their performance in predicting adverse events was compared to pulmonary artery elastance (PAE). PAE (mmHg/mL) was calculated by dividing the Pulmonary Artery Systolic pressure (PASP) by the LV Stroke (SV). Blood biomarkers (troponin T, NT-proBNP, and lactate) were recorded. The composite primary outcome was: 1) need for advanced intervention, 2) cardiac arrest, and 3) in-hospital mortality. Multivariate and univariate regression was used to analyze outcomes. Results: 215 of 343 patients met inclusion criteria. Baseline characteristics were similar in patients with PAE &lt;1 and PAE ≥ 1. PAE ≥ 1 was common in intermediate-high risk PE (85.7% vs 63.1%, p &lt;0.001), with greater [NT-proBNP, pg/mL] (3599 vs 1427.5, p=0.001) and [lactate, mM] (2.9 vs 1.8. p=0.003). PAE ≥ 1 predicted the composite endpoint with odds ratio (OR) of 2.31 (95% CI 1.3-4.2, p=0.005), Comparatively BOVA had adjusted OR of 1.3 (95% CI, 1.1-1.6, p = 0.01) and PESI was not significant with OR of 1.4 (95% CI, 1 -2.1, p = 0.055) in predicting composite outcomes. Conclusion: In the context of acute high risk PE, PAE ≥ 1.0 is a novel and independent predictor of adverse cardiovascular events and mortality that should be prospectively validated.
Performance Characterization of Monolithically Integrated mmW Phased Arrays (2018)

We present initial characterization of a novel, mono-lithically integrated multilayer mmW phased array architecture that can be seamlessly incorporated with large-scale fabrication of transceiver chipsets. Exhibiting an estimated radiation efficiency over 60% for the impedance bandwidth covering 35-75 GHz band, the ultra-wideband array topology offers a cost-effective realization with much improved on-chip performance. Moreover, the proposed array is an ideal candidate for conformal and mobile applications thanks to its low profile with the overall height of 500 μm and on-chip footprint of 7mm×3mm, exhibiting 5 dB realized gain.
Gaussian model for movement detection during Sleep (2012)

Quality of sleep is an important attribute of an individual's health state and its assessment is therefore a useful diagnostic feature. Changes in the patterns of mobility in bed during sleep can be a disease marker or can reflect various abnormal physiological and neurological conditions. This paper describes a method for detection of movement in bed that is evaluated on data collected from patients admitted for regular polysomnography. The system is based on load cells installed at the supports of a bed. Since the load cell signal varies the most during movement, the approach uses a weighted combination of the short-term mean-square differences of each load cell signal to capture the variations in the signal caused by movement. We use a single univariate Gaussian model to represent each class: movement versus non-movement. We assess the performance of the method against manual annotation performed by a sleep clinic technician from seventeen patients. The proposed detection method achieved an overall sensitivity of 97.9% and specificity of 98.7%.
Oxygen free radical activity in the second stage of labor (1997)

The duration of the second stage is correlated with raised reactive oxygen species-derived lipid peroxidation products. Caution should be exercised in the management of prolonged second stage of labor.
Aerial Robotic Construction towards a New Field of Architectural Research (2012)

This paper takes a first step in characterizing a novel field of architectural research - aerial robotic construction (ARC) - where aerial robotics is used not only for construction, but as a guiding principle in the design and fabrication process. Featuring autonomous flying vehicles that lift small building elements and position them according to a precise digital blueprint, ARC offers a comprehensive new approach to architecture research and technology. Developed by the research groups of Gramazio &amp; Kohler and Raffaello D'Andrea at ETH Zurich, ARC offers unique advantages over traditional approaches to building: it does not require scaffolding, it is easily scalable, and it offers digital integration and informational oversight across the entire design and building process. This paper considers 1) research parameters for the individual components of ARC (such as module design, connection methodologies, vehicle cooperation, and construction sequencing/synchronization), and 2) the architectural implications of integrating these discrete components into a systemic, unifying process at the earliest stages of design. Fidelity between the design concept and the full-scale construction is of particular concern.
Spectroscopy, kinetics and laser effects of photodissociated HgX (X=I, Br and Cl) (1987)

Spectroscopic and kinetic studies have been made on the mercurous halides HgX (X=Cl, Br, I) photodissociated from HgX2 by an ArF excimer laser excitation at 193 nm. The lifetimes and quenching rates of the HgX B(2 Sigma +12/) state have been determined from the properties of the B to X (2 Sigma +12/) emission. Comparison is made of the spectroscopic behaviour of the three halides and also between photon and electron dissociation. The HgX (B to X) spectra consist of numerous overlapping bands extending from the visible to the UV. The vibrational spectral distribution narrows from Cl, through Br to I and the peak emission wavelength becomes shorter. Characteristics of gain and laser action in HgBr have been investigated.
High rate vacuum deposition of polymer electrolytes (1996)

Two new, high rate, vacuum processes have been developed for the deposition of polymer electrolyte layers on wide web substrates. One method involves the vacuum extrusion of monomer salt solutions followed by e-beam or ultraviolet (UV) curing. The second method involves the vacuum flash evaporation of the monomer salt solution followed by e-beam or UV curing. Each method is compatible with simultaneous, in-line, deposition by conventional processes like sputtering or evaporation in a wide web system. Optically clear polymer electrolyte layers may be deposited at line speeds in excess of 100 meters per minute with these new techniques. Ionic conductivity measurements will be presented for vacuum deposited, evaporated and extruded, polymer electrolyte layers. Films were deposited with thicknesses ranging from 2 to 50 μm. Application of these methods to ongoing electrochromic and battery work at the Pacific Northwest Laboratory will be discussed.
Strain engineering in germanium microdisks (2014)

The keystone to realize a monolithic integrated source on silicon with germanium is to optimize tensile strain and n-doping. In order to realize an integrated compact source, we demonstrate highly strained n-doped germanium microdisks obtained by two approaches using initially compressed silicon nitride (SiN) deposition. In the first approach, the microdisks are fabricated from relaxed Ge. In a second approach, we use tensile-strained Ge grown on a mismatched buffer layer, thus increasing the global strain in the Ge volume and lowering its gradient. A photoluminescence red-shift up to 450 nm is observed, corresponding to more than 1% biaxial strain.
Abstract 2806: Inhibition of melanoma development by Isatin analogs (2018)

Abstract Despite major breakthroughs in melanoma drug development, there remains a need for new drugs and novel approaches. Of the three forms of skin cancer, malignant melanoma has the most significant impact on human health carrying the highest risk of mortality from metastasis. An estimated 87,110 new cases of invasive melanoma will be diagnosed and 9,730 people will die of melanoma in the USA in 2017. Melanoma accounts for less than one percent of skin cancer cases, but the vast majority of skin cancer deaths. The vast majority of melanomas are caused by the sun. In fact, one UK study found that about 86 percent of melanomas can be attributed to exposure to ultraviolet (UV) radiation from the sun. The estimated 5-year survival rate for patients whose melanoma is detected early is about 98 percent in the USA, whereas, the survival rate falls to 62 percent when the disease reaches the lymph nodes, and 18 percent when the disease metastasizes to distant organs. Thus, novel effective therapies are urgently needed to treat this disease. The Isatin (1H-indole-2,3-dione) is found as an endogenous molecule in humans and other mammals and its analogs display diverse types of biological activities including anti-cancer activities. Earlier our group synthesized a novel series of 5,7-dibromoisatin analogs. Various melanoma cells were treated with several Isatin derivatives having functional groups like selenocyanate, thiocyanates, thiourea, and selenourea for 72 hours and the cell survival was estimated by MTS assay. Agents were treated with melanoma cell lines UACC 903, 1205 Lu or normal fibroblast cell line FF2441. Treatment with KS99, a thiocyanate analog and KS101, a selenourea analog of 5,7-dibromoisatin effectively killed melanoma cells after 72 h treatment. Overall, IC50 values of Isatin derivatives on melanoma cell lines were 3.0-5.7μM and 2.1-5.7μM, respectively. IC50 value on normal fibroblast cells with these Isatin derivatives was 5.4-20.7μM. KS101 was toxic to the xenograft mice at 1mg/kg body weight, animals developed vein inflammatic symptoms after 20 days of treatment. However, liposomal formulation of KS101 was safe up to 30mg/kg body weight in 1205 xenografted nude mice when treated alternate days by tail vein injection. The melanoma tumor burden was reduced by 47%. We will discuss structural activity relationship (SAR) of Isatin derivatives, and its in vitro and in vivo inhibitory effects against melanoma. Citation Format: Dhimant H. Desai, Raghvendra Gowda, Krishne Gowda, Saketh S. Dinavahi, Gavin P. Robertson, Shantu G. Amin. Inhibition of melanoma development by Isatin analogs [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 2806.
Sequence-specific interaction of Hoescht 33258 with the minor grooVe of an adenine-tract DNA duplex studied in solution by1H NMR spectroscopy (1990)

The interaction of Hoechst 33258 with the minor groove of the adenine-tract DNA duplex d(CTTTTGCAAAAG)2 has been studied in both D2O and H2O solutions by 1D and 2D 1H NMR spectroscopy. Thirty-one nuclear Overhauser effects between drug and nucleotide protons within the minor groove of the duplex, together with ring-current induced perturbations to the chemical shifts of basepair and deoxyribose protons, define the position and orientation of the bound dye molecules. Two drug molecules bind cooperatively and in symmetry related orientations at the centre of the 5'-TTTT and 5'-AAAA sequences with the binding interactions spanning only the four A-T basepairs. The positively charged N-methylpiperazine moieties point towards the centre of the duplex while the phenol groups are disposed towards the 3'-ends of the sequence. Resonance averaging is apparent for both the D2/D6 and D3/D5 phenol protons and D2"'/D6"' and D3"'/D5"' of the N-methylpiperazine ring and is consistent with these groups being involved in rapid rotation or ring-flipping motions in the bound state. Interstrand NOEs between adenine H2s and deoxyribose H1' are consistent with a high degree of propeller twisting of the A-T basepairs at the binding site of the aromatic benzimidazole and phenol rings of Hoechst. The data imply that the minor groove is particularly narrow with many contacts between the complementary curved surfaces of the drug and DNA indicating that strong van der Waals interactions, involving the floor and the walls of the minor groove, stabilize the complex. In our model the NH groups of the benzimidazole rings are positioned to make a pair of bifurcated hydrogen bonds with the adenine N3 and thymine O2 on the floor of the minor groove.
World Transmissions for the 1990 Truck Market (1988)

&lt;div class="htmlview paragraph"&gt;A new line of on-highway transmissions has been designed and developed by Allison Transmission Division. This new product line, identified as the World Transmission Series (WT), has been designed with emphasis on cost-effectiveness, greater integration with vehicle systems and advanced technology to meet market demands into the 21st century.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;New design concepts both in power train component arrangement and electronic controls have been coupled utilizing concurrent engineering and systems engineering principles. The result is a customer-driven product line which, when produced by Allison, will exceed world class standards of quality, performance and value. &lt;/div&gt;
Effects of different frying techniques on the color, fatty acid profile, and lipid oxidation of Arapaima gigas (2018)

This study investigated the changes in the composition of the lipid fraction, as well as in the color and lipid oxidation of Arapaima gigas cubes subjected to two different frying methods (deep fat and air frying) at three different temperatures (150°C, 170°C, and 190°C) during the time needed for the geometric center of the samples to reach 70°C (7 min 42 s, 5 min 3 s, 2 min 50 s, 12 min 52 s, 8 min 44 s, and 5 min 2 s). The instrumental color parameters, lipid oxidation, and fatty acid profile were evaluated. The temperature and cooking method influenced (p ≤ 0.05) all the parameters evaluated. The samples submitted to the air frying method at lower temperatures demonstrated minor alterations. In contrast, the deep fat frying technique caused an increase of 33% in the content of the saturated fatty acids and up to 26% reduction in the content of polyunsaturated fatty acids. The lower temperatures caused minor alterations in the parameters evaluated in both the methods. Air-fried cubes presented a better fatty acid profile than deep fat fried cubes, and therefore air frying at 150°C is a suitable cooking method from a nutritional point of view. Practical applications Arapaima gigas is a freshwater fish species that is highly consumed in the northern and central-west regions of Brazil, with a great potential for exportation due mainly to its valuable protein and essential fatty acid source, high carcass yield, and meat flavor. However, frying, which is one of the most commonly used in meat products, may change the color and nutritional aspects depending on the processing conditions such as frying method, temperature, and time. In this study, two different frying methods (deep fat and air frying) at three different temperatures (150°C, 170°C, and 190°C) during the time needed for the geometric center of the samples reached 70°C were tested in A. gigas meat. Air frying technique at 150°C presented a better fatty acid profile than the deep fat frying method, and can be considered a suitable cooking method from a nutritional point of view.
A general purpose proxy filtering mechanism applied to the mobile environment (1997)

In recent years, proxies have become more prevalent. Generally, these systems are used to process data tlowing between two endpoints using an intermediary. More specifically, they can be used to filter or process traffic flowing to and from a network-limited host. Benefits include more efficient use of network resources, reduced cost, and increased security. In this paper, we describe the design and capabilities of such a system, how it has been applied to the mobile environment, and provide an evaluation of the work.
Peripheral blood and neuropsychological markers for the onset of action of antidepressant drugs in patients with Major Depressive Disorder (2011)

This investigation will help to identify a biomarker or a set of biomarkers with decision-making quality in the treatment of MDD in order to increase the currently disappointing remission rates of antidepressant treatment.