gebhart/patrepeval huggingface dataset:
Quantification of YouTube QoE via Crowdsourcing (2011)

This paper addresses the challenge of assessing and modeling Quality of Experience (QoE) for online video services that are based on TCP-streaming. We present a dedicated QoE model for You Tube that takes into account the key influence factors (such as stalling events caused by network bottlenecks) that shape quality perception of this service. As second contribution, we propose a generic subjective QoE assessment methodology for multimedia applications (like online video) that is based on crowd sourcing - a highly cost-efficient, fast and flexible way of conducting user experiments. We demonstrate how our approach successfully leverages the inherent strengths of crowd sourcing while addressing critical aspects such as the reliability of the experimental data obtained. Our results suggest that, crowd sourcing is a highly effective QoE assessment method not only for online video, but also for a wide range of other current and future Internet applications.
Abstract 1478: Angiogenesis After a Myocardial Infarction is Regulated by Bone Marrow c-kit+ Cells (2006)

Introduction: Clinical trials of bone marrow stem cell therapy after myocardial infarction (MI) have shown promising results, but the mechanism for the benefit is unclear. We examined the endogenou...
Selective androgen receptor modulators activate the canonical prostate cancer androgen receptor program and repress cancer growth (2021)

Prostate cancer (PC) is driven by androgen receptor (AR) activity, a master regulator of prostate development and homeostasis. Frontline therapies for metastatic PC deprive the AR of the activating ligands testosterone (T) and dihydrotestosterone (DHT) by limiting their biosynthesis or blocking AR binding. Notably, AR signaling is dichotomous, inducing growth at lower activity levels, while suppressing growth at higher levels. Recent clinical studies have exploited this effect by administration of supraphysiological concentrations of T, resulting in clinical responses and improvements in quality of life. However, the use of T as a therapeutic agent in oncology is limited by poor drug-like properties as well as rapid and variable metabolism. Here, we investigated the antitumor effects of selective AR modulators (SARMs), which are small-molecule nonsteroidal AR agonists developed to treat muscle wasting and cachexia. Several orally administered SARMs activated the AR program in PC models. AR cistromes regulated by steroidal androgens and SARMs were superimposable. Coregulatory proteins including HOXB13 and GRHL2 comprised AR complexes assembled by both androgens and SARMs. At bioavailable concentrations, SARMs repressed MYC oncoprotein expression and inhibited the growth of castration-sensitive and castration-resistant PC in vitro and in vivo. These results support further clinical investigation of SARMs for treating advanced PC.
Beta protein 1homeoprotein induces cell growth and estrogen-independent tumorigenesis by binding to the estrogen receptor in breast cancer (2016)

Expression of Beta Protein 1 (BP1), a homeotic transcription factor, increases during breast cancer progression and may be associated with tumor aggressiveness. In our present work, we investigate the influence of BP1 on breast tumor formation and size in vitro and in vivo. Cells overexpressing BP1 showed higher viability when grown in the absence of serum (p < 0.05), greater invasive potential (p < 0.05) and formed larger colonies (p < 0.004) compared with the controls. To determine the influence of BP1 overexpression on tumor characteristics, MCF-7 cells transfected with either empty vector (V1) or overexpressor plasmids (O2 and O4) were injected into the fat pads of athymic nude mice. Tumors grew larger in mice receiving O2 or O4 cells than in mice receiving V1 cells. Moreover, BP1 mRNA expression levels were positively correlated with tumor size in patients (p = 0.01). Interestingly, 20% of mice injected with O2 or O4 cells developed tumors in the absence of estrogen, while no mice receiving V1 cells developed tumors. Several mechanisms of estrogen independent tumor formation related to BP1 were established. These data are consistent with the fact that expression of breast cancer anti-estrogen resistance 1 (BCAR1) was increased in O2 compared to V1 cells (p < 0.01). Importantly, O2 cells exhibited increased proliferation when treated with tamoxifen, while V1 cells showed growth inhibition. Overall, BP1 overexpresssion in MCF-7 breast cancer cells leads to increased cell growth, estrogen-independent tumor formation, and increased proliferation. These findings suggest that BP1 may be an important biomarker and therapeutic target in ER positive breast cancer.
Light down-conversion with over 100% external quantum efficiency in bulk germanium (2012)

To bypass indirect bandstructure limitations in Ge and have it effectively emitting, we employ light down conversion process at elevated temperatures (emissivity enhancement technique). By applying short wavelength pump light (λin, interband electron transitions), we enhance thermal emission output in the spectral range of intraband electron transitions (λout, free carrier absorption band). We experimentally realized conditions (λin = 1.9 μm, λout = 2–25 μm, T = 380 K) when Ge wafers demonstrated power conversion efficiency of 21% and external quantum efficiency (photon multiplication coefficient) of 130%. Advantages of Ge over Si and ways to realize Ge-based radiative cooler are discussed.
Carrier dynamics of AlGaAs/AlAs asymmetric double quantum wells with different barrier thickness (2022)

Optical properties and carrier dynamics of AlGaAs/AlAs asymmetric double quantum wells (ADQWs) with varied barrier thickness are studied by excitation-power-dependent photoluminescence (PL) and temperature-dependent time-resolved PL (TRPL) experiments. The origin of the transition energies derived from the time-integrated spectra is confirmed by theoretical calculation using the Schrödinger equation. The carrier kinetics and the temporal behavior of the emission in the narrow well (NW) and wide well (WW) are physically revealed with varying barrier thicknesses by the TRPL measurements. For a better understanding of the carrier transport mechanism, the electron tunneling times for the ADQWs are theoretically estimated based on a rate-equation model. The calculation indicates that the electron tunneling time decreases with increasing temperature, which may be induced by enhanced phonon-assisted scattering.
Immunocytochemical Observations of Corticotropin-Releasing-Factor-Containing Neurons in the Rat Hypothalamus with Special Reference to Neuronal Communication (1985)

Synapses between neurons with corticotropin-releasing-factor-(CRF)-like immunoreactivities and other immunonegative neurons in the hypothalamus of colchicine-treated rats, especially in the paraventricular nucleus (PVN) and the supraoptic nucleus (SON) were observed by immunocytochemistry using CRF antiserum. The immunoreactive nerve cell bodies and fibers were numerous in both the PVN and the SON. The CRF-containing neurons had synaptic contacts with immunonegative axon terminals containing a large number of clear synaptic vesicles alone or combined with a few dense-cored vesicles. We also found CRF-like immunoreactive axon terminals making synaptic contacts with other immunonegative neuronal cell bodies and fibers. And since some postsynaptic immunonegative neurons contained many large neurosecretory granules, they are considered to be magnocellular neurosecretory cells. These findings suggest that CRF functions as a neurotransmitter and/or modulator in addition to its function as a hormone.
Upper Mantle Structure Beneath the Hawaiian Swell: Constraints From the Ocean Seismic Network Pilot Experiment (2002)

[1] Data from two broadband, ocean-bottom seismographic stations deployed ∼225 km southwest of Oahu, Hawaii during the Ocean Seismic Network Pilot Experiment provide constraints on upper mantle structure beneath the Hawaiian swell. Receiver functions show that the mantle transition zone is thinned by >50 km relative to reference model PA5, which, in the absence of compositional changes, implies excess temperatures of >350 K in the transition zone. The combination of the measurements reported here and the thickness variations reported by Li et al. [2000] imply that the transition zone is thinned by 30 ± 15 km over an along-swell dimension of at least 700 km. At ∼80 km depth, P-to-S converted phases are identified from the Gutenberg discontinuity marking the lid of the oceanic low-velocity zone and the base of the lithosphere. Shear-wave splitting measurements imply that fast-polarization azimuths are intermediate between the absolute plate-motion vector and the fossil spreading direction; multi-event stacked values of o and δt are −80° and 1.5 s, respectively.
Insighting role of reduced graphene oxide in BiVO4 nanoparticles for improved photocatalytic hydrogen evolution and dyes degradation (2019)

Hydrogen energy production and dyes degradation have been considered the need of modern age of technology in globe irrespective of the level of science and research in that country. Hydrogen gas is a green energy fule for the future application and abunduntly available in environment. Various techniques are reported for the production of hydrogen energy among which photocatalysis method is envirnmental friendly, cost-efficient method using water that also decontaminated from dyes, which is a main problem nowadays because of increase in industrial applications according to the living standards. The composite of Bismuth vanadate (BiVO4) with the coupling of the rduced graphene oxide (rGO) were synthezied by the facial hydrothermal technique by using a bismuth nitrate penta hydrate and amonium metavanadate as main precour and graphene oxide solution for reduced graphene oxide incorporation. X-ray diffraction (XRD), Scanning Electron Microscope (SEM), ultraviolet adsorption spectroscopy (UV-vis), and Brunauer-Emmett-Teller (BET) characterization tools investigate the role of concentration of the coupling material rGO in BiVO4. All characterization techniques confirms that 1.5% rGO/BiVO4 shows transformation of tetragonal to monoclinic phase with altration of the particles size (25-40 nm), with high-surface area, having irregular spherical porous clusters degradation of methelene blue (97%), production of green energy in the form of hydrogen gas fuel, and enhancement of the absorption of light that is clear intimation of the high photocatalytic efficiency towards the decontamination of the wastewater and production of hydrogen gas. Prepared nanostructured composite in current work reveals effective photocatalytic activity for decontamination of the wastewater and evolution of hydrogen energy would be the precise idea to utilize them in near future with various promising applications.
Effects of CDP-choline administration on receptor-stimulated inositol phospholipid hydrolysis in brain slices and neuronal cultures. (1992)

Repeated addition of CDP-choline (100 microM, once a day since the 2nd day of maturation in culture) to corticostriatal neurons led to an increased basal hydrolysis of inositol phospholipids, as revealed by an enhanced formation of [3H]inositolmonophosphate ([3H]InsP) in the presence of 10 mM Li+. This increase was prevented by the muscarinic receptor antagonist, atropine, or by tetrodotoxin, but not by other receptor antagonists, such as L-2-amino-4-phosphonobutanoate (L-AP4), prazosin or ketanserin. The increase in inositol phospholipid hydrolysis induced by repeated addition of CDP-choline was obliterated when cultures were incubated in the presence of the muscarinic receptor agonist, carbamylcholine. CDP-choline had no effect on inositol phospholipid hydrolysis in cultured cerebellar neurons, which are devoid of cholinergic cells. The basal hydrolysis of inositol phospholipids was also increased in hippocampal slices prepared from rats repeatedly injected with CDP-choline (200 mg/kg, i.p. for 15 days). As observed in cultured cortico-striatal neurons, this increase was prevented by atropine and was masked in the presence of carabamylcholine. Taken collectively, these data indicate that repeated exposure to exogenous CDP-choline increases polyphosphoinositide turnover, an effect that results from an increased availability of acetylcholine acting on muscarinic receptors.
Iterative interference alignment for cellular systems with user selection (2012)

An iterative interference alignment algorithm for cellular systems with multiple signaling dimensions is introduced. The main invention is that we combine iterative interference alignment with user selection, which naturally increases the system sum rate by exploiting the multiuser diversity. Extensive simulations show significant gains over single cell processing and joint/coherent transmit schemes, also with partial channel state information.
Trends of color liquid crystal display devices. (1986)

カラー液晶表示素子の最近の動向について, 加法混色方式によるカラーフィルタを用いたアクティブマトリックス駆動型LCDに重点を置いて述べる.
ChemInform Abstract: Recyclization of Enamino Nitriles of 1,3‐Dithiacyclohexenes. A Novel Route to the Stereoselective Synthesis of Substituted 3,4‐trans‐1,2,3,4‐Tetrahydro‐6‐pyridinethiolates. (1990)

Abstract The aminodithiincarbonitriles (II) are coupled with the pyridinium salt (Ia) to give the pyridiniopyridinethiolates (IIIa) and (IIIb).
Parasitism of iron-siderophore receptors of Escherichia coli by the siderophore-peptide microcin E492m (2005)

Microcins are gene-encoded antibacterial peptides secreted by enterobacteria. They are believed to play a major role in the microbial competitions within the intestinal tract. We have recently isolated a posttranslationally modified form of the 84-residue microcin E492 named MccE492m. MccE492m posttranslational modification was characterized as a trimer of N-(2,3-dihydroxybenzoyl)-L-serine (DHBS) linked to the Ser84-carboxylate via a beta-D-glucose moiety. MccE492m was shown to bind iron through the trimer of DHBS. This is the first example of a novel type of antibacterial peptide called siderophore-peptide. Recognition of both modified and unmodified MccE492 was shown to be mediated by the FepA, Cir and Fiu iron-siderophore receptors at the outer membrane of E. coli. However, the siderophore-mimicking modification was shown to significantly improve the microcin activity. Thus, we propose that MccE492 and MccE492m parasitize iron-siderophore receptors for uptake into the target bacteria and that improvement of MccE492 antimicrobial activity upon modification results from an increase in the microcin/receptor affinity.
Monolithic expandable 6 bit 20 MHz CMOS/SOS A/D converter (1979)

Standard process CMOS/SOS technology has been applied in the design of a 6 bit parallel 20 MHz A/D converter. Two chips may be interconnected in a series to obtain 7 bit resolution or in parallel to obtain nearly 40 MHz data rates. Design factors and accuracy requirements are reviewed.
Effects of Alcohol and Acetate on Cerebral Blood Flow: A Pilot Study (2019)

Increased thalamic CBF associated with either alcohol or acetate administration suggests that the thalamic CBF response after alcohol could be mediated by acetate. Compared to other brain regions, thalamus may differ in its ability to metabolize acetate or expression of receptors responsive to acetate. Increased prefrontal and limbic CBF associated with alcohol may be linked to alcohol's behavioral effects.
Desalination of brackish groundwater and reuse of wastewater by forward osmosis coupled with nanofiltration for draw solution recovery (2019)

This study evaluates a treatment system centered on forward osmosis (FO) to extract high-quality water from real brackish groundwater and wastewater. The groundwater had salinity of 4 g/L, while the wastewater sample consisted of a secondary effluent. These feed solutions were treated first in a FO step, achieving a recovery of >60%. Subsequently, the diluted draw solutions were subject to a nanofiltration (NF) step to regenerate their original osmotic pressure and to simultaneously collect a final permeate product. Magnesium chloride and sodium sulfate were both suitable draw solutes for this application. MgCl<sub>2</sub> had a larger specific reverse salt flux and induced a more pronounced fouling-related flux decline with groundwater samples. Na<sub>2</sub>SO<sub>4</sub> was re-concentrated with a higher permeability NF membrane but may require the use of anti-scalants. The average fluxes obtained in high-recovery batch FO were between 5 and 11 L m<sup>-2</sup>h<sup>-1</sup> with an initial bulk draw osmotic pressure in the range of 12-15 bar. Relatively low flux decline was observed in fouling experiments with both samples, while physical cleaning proved promising to recover the related loss in productivity. The final product waters were all of very high quality, suggesting the potential of this coupled system for water reuse and desalination. Some challenges related to the relatively low water flux in the FO step, as well as the loss of draw solutes and the gradual change in composition of the draw solution, need further analysis to establish the technical and economic feasibility of the system.
Trans-Arctic propagation for ocean climate studies (1994)

Long-term observations over many years of the changes in acoustic phase, travel time, and amplitude for many trans-Arctic paths could provide synoptic measurements of Arctic Ocean temperature and sea ice properties (particularly average ice thickness), crucial elements of the Arctic climate that plays a significant role in the Earth’s climate system as well as being a sensitive indicator of global climate change. The response of acoustic phase and amplitude to changes in Arctic Ocean temperature, and changes in sea ice coverage and thickness have been estimated for a trans-Arctic path of 2700 km at 30 Hz. Low frequencies (&amp;lt;40 Hz) are required in the Arctic due to the large scattering losses from the ice (indeed, one of the observables). The travel time and phase ‘‘noise’’ caused by ‘‘short-term’’ mesoscale and internal wave modulation of the Arctic Ocean temperature are calculated to be negligible. Phase measurements made in the Arctic over a 320-km path at 30 Hz [P. N. Mikhalevsky, J. Acoust. Soc. Am. 70, 1717–1722 (1981)] demonstrated phase detection to better than one hundredth of a cycle with observed short-term phase fluctuations consistent with the mesoscale calculations. However, these observations were too short in time and in range for any definitive conclusions regarding trans-Arctic paths. An experiment is planned in late April to transmit signals at 20 Hz from a Russian ice camp off Spitzbergen to a vertical array in the Lincoln Sea, and horizontal and vertical arrays at an ice camp in the Beaufort Sea.
A multi-agent approach to power system restoration (2002)

This paper proposes a multi-agent approach to power system restoration. The proposed system consists of a number of bus agents (BAGS) and a single facilitator agent (FAG). BAG is developed to decide a suboptimal target configuration after a fault occurrence by interacting with other BAGS based on only locally available information, while FAG is to act as a manager in the decision process. The interaction of several simple agents leads to a dynamic system, allowing efficient approximation of a solution. Simulation results have demonstrated that this method is able to reach suboptimal target configurations, which are favorably compared with those obtained by a mathematical programming approach.
Development of Response-Selective Agonists of Human C5a Anaphylatoxin Conformational, Biological, and Therapeutic Considerations (2001)

Numerous studies on the relationship between the structure and function of peptide agonists derived from the biologically active, C-terminal region of human C5a anaphylatoxin have been reported over the past decade. These studies have been performed with the objective of parlaying this structure-function information into the design of peptide/peptidomimetic modulators of C5a receptor (C5aR)-mediated function. In this review, we describe a rational approach for the development of conformationally biased, decapeptide agonists of C5a and described how these stabilized and specific conformational features relate to the expression of specific C5a-like activities in vitro and in vivo. The therapeutic potential of such response-selective C5a agonists is discussed and underscored by the results of one such response-selective C5a agonist that was used in vivo as an effective molecular adjuvant capable of generating antigen-specific humoral and cellular immune responses. Finally, we describe the synthesis of a new generation of highly response-selective, conformationally biased C5a agonist and discuss the in vitro and in vivo biologic results that so indicate this biologic selectivity.
Endothelial Phospholipase Cγ2 Improves Outcomes of Diabetic Ischemic Limb Rescue Following VEGF Therapy (2022)

Therapeutic vascular endothelial growth factor (VEGF) replenishment has met with limited success for the management of critical limb-threatening ischemia. To improve outcomes of VEGF therapy, we applied single-cell RNA sequencing (scRNA-seq) technology to study the endothelial cells of the human diabetic skin. Single-cell suspensions were generated from the human skin followed by cDNA preparation using the Chromium Next GEM Single-cell 3′ Kit v3.1. Using appropriate quality control measures, 36,487 cells were chosen for downstream analysis. scRNA-seq studies identified that although VEGF signaling was not significantly altered in diabetic versus nondiabetic skin, phospholipase Cγ2 (PLCγ2) was downregulated. The significance of PLCγ2 in VEGF-mediated increase in endothelial cell metabolism and function was assessed in cultured human microvascular endothelial cells. In these cells, VEGF enhanced mitochondrial function, as indicated by elevation in oxygen consumption rate and extracellular acidification rate. The VEGF-dependent increase in cell metabolism was blunted in response to PLCγ2 inhibition. Follow-up rescue studies therefore focused on understanding the significance of VEGF therapy in presence or absence of endothelial PLCγ2 in type 1 (streptozotocin-injected) and type 2 (db/db) diabetic ischemic tissue. Nonviral topical tissue nanotransfection technology (TNT) delivery of CDH5 promoter–driven PLCγ2 open reading frame promoted the rescue of hindlimb ischemia in diabetic mice. Improvement of blood flow was also associated with higher abundance of VWF+/CD31+ and VWF+/SMA+ immunohistochemical staining. TNT-based gene delivery was not associated with tissue edema, a commonly noted complication associated with proangiogenic gene therapies. Taken together, our study demonstrates that TNT-mediated delivery of endothelial PLCγ2, as part of combination gene therapy, is effective in diabetic ischemic limb rescue.
Cutting Edge: Oseltamivir Decreases T Cell GM1 Expression and Inhibits Clearance of Respiratory Syncytial Virus: Potential Role of Endogenous Sialidase in Antiviral Immunity (2007)

The sialoglycosphingolipid GM1 is important for lipid rafts and immune cell signaling. T cell activation in vitro increases GM1 expression and increases endogenous sialidase activity. GM1 expression has been hypothesized to be regulated by endogenous sialidase. We tested this hypothesis in vivo using a mouse model of respiratory syncytial virus (RSV) infection. RSV infection increased endogenous sialidase activity in lung mononuclear cells. RSV infection increased lung CD8+ T cell surface GM1 expression. Activated CD8+ T cells in the lungs of RSV-infected mice were GM1(high). Treatment of RSV-infected mice with the sialidase/neuraminidase inhibitor oseltamivir decreased T cell surface GM1 levels. Oseltamivir treatment decreased RSV-induced weight loss and inhibited RSV clearance. Our data indicate a novel role for an endogenous sialidase in regulating T cell GM1 expression and antiviral immunity. Also, oseltamivir, an important anti-influenza drug, inhibits the clearance of a respiratory virus that lacks a neuraminidase gene, RSV.