gebhart/patrepeval huggingface dataset:
Data from The TWEAK Receptor Fn14 Is an Src-Inducible Protein and a Positive Regulator of Src-Driven Cell Invasion (2023)

&lt;div&gt;Abstract&lt;p&gt;The TNF receptor superfamily member Fn14 (TNFRSF12A) is the sole signaling receptor for the proinflammatory cytokine TWEAK (TNFSF12). TWEAK:Fn14 engagement stimulates multiple signal transduction pathways, including the NF-κB pathway, and this triggers important cellular processes (e.g., growth, differentiation, migration, and invasion). The TWEAK–Fn14 axis is thought to be a major physiologic mediator of tissue repair after acute injury. Various studies have revealed that Fn14 is highly expressed in many solid tumor types, and that Fn14 signaling may play a role in tumor growth and metastasis. Previously, it was shown that Fn14 levels are frequently elevated in non–small cell lung cancer (NSCLC) tumors and cell lines that exhibit constitutive EGFR phosphorylation (activation). Furthermore, elevated Fn14 levels increased NSCLC cell invasion &lt;i&gt;in vitro&lt;/i&gt; and lung metastatic tumor colonization &lt;i&gt;in vivo&lt;/i&gt;. The present study reveals that EGFR-mutant NSCLC cells that express high levels of Fn14 exhibit constitutive activation of the cytoplasmic tyrosine kinase Src, and that treatment with the Src family kinase (SFK) inhibitor dasatinib decreases Fn14 gene expression at both the mRNA and protein levels. Importantly, siRNA-mediated depletion of the SFK member Src in NSCLC cells also decreases Fn14 expression. Finally, expression of the constitutively active v-Src oncoprotein in NIH 3T3 cells induces Fn14 gene expression, and NIH 3T3/v-Src cells require Fn14 expression for full invasive capacity.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Implications:&lt;/b&gt; These results indicate that oncogenic Src may contribute to Fn14 overexpression in solid tumors, and that Src-mediated cell invasion could potentially be inhibited with Fn14-targeted therapeutics. &lt;i&gt;Mol Cancer Res; 13(3); 575–83. ©2014 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Mantyl tagged oligo α (1 → 2) mannosides as Candida albicans β-mannosyl transferases substrates: a comparison between synthetic strategies (2013)

Fluorescent oligomannosides are important tools for the evaluation of mannosyl transferase activities and selectivities. In a project dealing with Candida albicans β-mannosyl transferases, three mantyl tagged α (1 → 2) oligomannosides were prepared by different ways: using all ester strategy compatible with the presence of an azido group suitable for direct click chemistry; and alternatively using the more classic benzyl protecting groups. Although more elegant, the all ester strategy has shown important limitations: reduced reactivity of mannosyl donors, and 3 → 2 ester migration. Preliminary enzymatic studies have shown that the synthetic oligomannosides are efficient substrate of β-mannosyl transferases.
Pitch Modelling for Speech Coding at 4.8 kbitsls (1993)

The purpose of this thesis is to examine techniques of efficiently modelling the Long-Term Predictor (LTP) or the pitch filter in low rate speech coders. The emphasis in this thesis is on a class of coders which are referred to as Linear Prediction (LP) based analysis-by-synthesis coders, and more specifically on the Code-Excited Linear Prediction (CELP) coder which is currently the most commonly used in low rate transmission. The experiments are performed on a CELP based coder developed by the U.S. Department of Defense (DoD) and Bell Labs, with an output bit rate of 4.8 kbits/s. A multi-tap LTP outperforms a single-tap LTP, but at the expense of a greater number of bits. A single-tap LTP can be improved by increasing the time resolution of the LTP. This results in a fractional delay LTP, which produces a significant increase in prediction gain and perceived periodicity at the cost of more bits, but less than for the multi-tap case. The first new approach in this work is to use a pseudo-three-tap pitch filter with one or two degrees of freedom of the predictor coefficients, which gives a better quality
Hydration and Ordering of Lamellar Block Copolymer Films under Controlled Water Vapor (2014)

Amphiphilic block copolymers within a range of volume fraction spontaneously form vesicles in aqueous solution, where a water core is enclosed by a polymer bilayer. Thin-film rehydration is a method used to produce vesicles routinely; a thin film is immersed in water, the film swells, and vesicles are formed which bleb off from the film surface. We have studied the early stages of hydration for PEO–PBO block copolymer thin films under controlled water vapor conditions to understand this formation mechanism and so enable more efficient ways to encapsulate molecules using this method. Neutron and X-ray measurements show that the initial film exhibits weakly ordered structure with isotropic parallel and vertical orientation; the films initially swell and maintain the same orientation. At a critical point the layer swells rapidly and makes highly ordered lamellae structure at the same time. The lamellae are almost exclusively oriented parallel to the substrate and swell with increasing water absorption.
Common Oral Manifestations During Pregnancy: A Review (2003)

After completion of this article, the reader will be able to summarize the major oral complications during pregnancy, to outline the etiologic factors associated with each of these conditions, and to explain the role of dental treatment during pregnancy.
4-Azatricyclo[5.2.2.02,6]undecane-3,5,8-triones as Potential Pharmacological Agents (2008)

A series of twenty six arylpiperazine and aminoalkanol derivatives of 4-azatricyclo[5.2.2.0(2,6)]undecane-3,5,8-trione have been prepared. The synthesized compounds were evaluated for their cytotoxicity and anti-HIV-1 activity in MT-4 cells.
Novel spin on planarization technology by photo curing SOC (P-SOC) (2017)

In advanced lithography technology, high planarity SOC (Spin-on-Carbon) materials which can planarize topography substrates are required in order to obtain enough process margin. We developed photo curing SOC (P-SOC) materials which can be cross-link by short wavelength UV light, but not thermal process. The P-SOC can achieve high planarization and good via filling because they have high reflow performance without viscosity increasing by baking process and almost no film shrinkage during the baking and photo curing process. The novel P-SOC materials are suitable for very fine pattern manufacturing process as N5 generation which is needed planarization technology.
Surface chemistry of titania (anatase) and titania-supported catalysts (1996)

The first page of this article is displayed as the abstract.
[Usefulness of clinical examination in detecting infectious foci prior to cardiac surgery]. (2000)

Routine ENT examination is not necessary prior to cardiac surgery. The patient history can be used to select patients for further evaluation.
ChemInform Abstract: AN UNEXPECTED BLUE SHIFT CAUSED BY DIFFERENTIAL SOLVATION OF A CHROMOPHORE ORIENTED IN A LIPID BILAYER (1979)

Abstract Der Chromophor (III) zeigt in Wasser, Ethanol, Butanol und wäßriger Na‐dodecylsulfat‐Lösung die erwartete UV‐Rotverschiebung, dagegen wird durch Lecithine eine merkliche Blauverschiebung induziert.
Design and Implementation of High-Throughput Screening Assays (2009)

HTS is at the core of the drug discovery process, and so it is critical to design and implement HTS assays in a comprehensive fashion involving scientists from the disciplines of biology, chemistry, engineering, and informatics. This requires careful analysis of many variables, starting with the choice of assay target and ending with the discovery of lead compounds. At every step in this process, there are decisions to be made that can greatly impact the outcome of the HTS effort, to the point of making it a success or a failure. Although specific guidelines should be established to ensure that the screening assay reaches an acceptable level of quality, many choices require pragmatism and the ability to compromise opposing forces.
Design of an Integrated Continuous Manufacturing System (2017)

This chapter presents a systematic, 12-step approach for designing, implementing, integrating, optimizing, and validating a continuous manufacturing system. Wherever appropriate, it also discusses the regulatory relevance of the technology integration effort. When considering the development of a continuous manufacturing facility, the industrial practitioner is well advised to consider very carefully not only the short-term intended use of the facility, but also other needs and demands that are likely to emerge. The implementation and efficient operation of an integrated continuous facility requires a heavy dose of "process engineering" skills. A thorough understanding of pharmaceutical raw materials and intermediate blends is crucial to the successful design of a robust continuous process, wherein achieving and maintaining a steady operation is paramount. Once the properties of individual materials have been examined, the next step in the design and development of a continuous process is the characterization of individual unit operations using the actual, characterized process materials.
Synthesis and Secretion of Hemoglobin by Retinal Pigment Epithelium (2009)

Hemoglobin expression by human RPE brings a new perspective to the understanding of oxygen transport to the outer retina. Malfunction of RPE-hemoglobin production may underlie the pathophysiology of ocular diseases characterized by subfoveal hypoxia and VEGF upregulation, such as age-related macular degeneration and diabetic retinopathy. Pharmacologic modulations of local hemoglobin production in RPE cells will create new opportunities to interfere with the course of these diseases.
Diversity and redundancy of the ripening regulatory networks revealed by the fruitENCODE and the new CRISPR/Cas9 CNR and NOR mutants (2019)

Tomato is considered as the genetic model for climacteric fruits, in which three major players control the fruit ripening process: ethylene, ripening transcription factors, and DNA methylation. The fruitENCODE project has now shown that there are multiple transcriptional circuits regulating fruit ripening in different species, and H3K27me3, instead of DNA methylation, plays a conserved role in restricting these ripening pathways. In addition, the function of the core tomato ripening transcription factors is now being questioned. We have employed CRISPR/Cas9 genome editing to mutate the <i>SBP</i>-<i>CNR</i> and <i>NAC</i>-<i>NOR</i> transcription factors, both of which are considered as master regulators in the current tomato ripening model. These plants only displayed delayed or partial non-ripening phenotypes, distinct from the original mutant plants, which categorically failed to ripen, suggesting that they might be gain-of-function mutants. Besides increased DNA methylation genome-wide, the original mutants also have hyper-H3K27me3 in ripening gene loci such as <i>ACS2</i>, <i>RIN</i>, and <i>TDR4</i>. It is most likely that multiple genetic and epigenetic factors have contributed to their strong non-ripening phenotypes. Hence, we propose that the field should move beyond these linear and two-dimensional models and embrace the fact that important biological processes such as ripening are often regulated by highly redundant network with inputs from multiple levels.
Deep Learning for the Automation of Particle Analysisin Catalyst Layers for Polymer Electrolyte Fuel Cells (2021)

The rapidly growing use of imaging infrastructure in the energy materials domain drives significant data accumulation in terms of their amount and complexity. The applications of routine techniques for image processing in materials research are often \textit{ad hoc}, indiscriminate, and empirical, which renders the crucial task of obtaining reliable metrics for quantifications obscure. Moreover, these techniques are expensive, slow, and often involve several preprocessing steps. This paper presents a novel deep learning-based approach for the high-throughput analysis of the particle size distributions from transmission electron microscopy (TEM) images of carbon-supported catalysts for polymer electrolyte fuel cells. Our approach employs training an instance segmentation model, called StarDist [Schmidt et al. Medical Image Computing and Computer-Assisted Intervention – MICCAI 2018, Lecture Notes in Computer Science, vol 11071. Springer, Cham], which resolves the main challenge in the pixel-wise localization of nanoparticles in TEM images: the overlapping particles. The segmentation maps outperform models reported in the literature, and the results on particle size analyses agree well with manual particle size measurements, albeit at a significantly lower cost.
In vitro maturation and fertilization of goat oocytes. (1991)

Goat oocytes were isolated from 3-5 mm diam. follicles. The oocytes with compact cumulus mass were matured and fertilized in vitro. Three different media, viz. modified Krebs-Ringer bicarbonate, Dulbecco's and Ham's F-12 with three different additives (bovine serum albumin, BSA; follicle stimulating hormone, FSH and fetal calf serum, FCS) were tested. The three basal media gave almost similar results with Ham's F-12 being slightly better. Addition of BSA (10 mg/ml) increased the rates of maturation and penetration. FSH + BSA (2.5 micrograms/ml + 10 mg/ml) further enhanced the rates while FCS (10%) proved to be even more effective. In modified Krebs-Ringer bicarbonate and Dulbecco media with additives FCS + BSA, around 60% oocytes matured to metaphase II of which 53% were penetrated by capacitated goat spermatozoa while in F-12 medium 70% reached metaphase II and 63% were penetrated. Ham's F-12 medium with additives FCS + BSA was slightly better for maturation and penetration of goat oocytes in comparison to two other media tested.
Characterization of Heavy Metal Incorporation in Calcite by XAFS Spectroscopy (1997)

Abstract: Zn and Co K-edge XAFS have been analyzed for spectra obtained from synthetic calcite that incorporated trace amounts of zn2+ and co2+ during growth from aqueous solutions at room temperature. Zn and Co concentrations in the calcite ranged from 250 to 2150 ppm. Analysis of the first shells indicates that the immediate coordination of both metal ions is approximately six oxygens at 2.11-2.12 A. These results are consistent with octahedral coordination at the unique Ca site in calcite. The observation that Co and Zn attain similar coordination in the bulk following incorporation suggests that their strongly contrasting surface site preferences are not expressed after being buried by subsequent growth layers. 1.
Community-Based Seroprevalence of SARS-CoV-2 Antibodies following the First Wave of the COVID-19 Pandemic in Jazan Province, Saudi Arabia (2021)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread globally, causing unprecedented effects on global health and economies. Community-based serological data are essential for understanding the true prevalence of infections, specifically the subclinical infections, as COVID-19 asymptomatic infections are common. Such data would also be important for decision making around choosing appropriate epidemiological control measures, as well as for the true estimation of mortality rates in the population. Further, determining the seroprevalence of anti-SARS-CoV-2 antibodies in the population would provide important information on herd immunity. In this study, we conducted a population-based age-stratified serological study to understand the prevalence of SARS-CoV-2 in Jazan Province, Saudi Arabia. Out of 594 participants who were recruited from 29 August to 30 December 2020, just before the vaccination rollout program in Saudi Arabia, about 157 were seropositive for SARS-CoV-2, indicating an estimated seropositivity rate of 26%. Although no significant difference in seropositivity was seen between male and female participants, we found that lower seroprevalence was associated with the younger (below 18 years old) and older populations (older than 56 years) compared with other age groups (19-55 years). These data indicate a high prevalence of SARS-CoV-2 antibodies following the peak of COVID-19 spread in Jazan province; however, most of the population (three-quarters) remains susceptible to SARS-CoV-2 infection.
Pain Management Doesn't have to be a Pain: Working and Communicating Effectively with Patients who have Chronic Pain (2005)

A Three-Step ApproachAn effective approach for working and communicating with pain patients at an office visit can be conceptualized as consisting of three steps: measuring and assessing; planning the treatment; and delivering the treatment.To enhance communication with patients and to emphasize selected points, clinicians should feel free to use visual aids, such as preprinted handouts and spontaneous drawings or notes. Measure and Assess the PainTo understand the "big picture" of measuring pain and assessing the impact of pain on the patient, you
<title>Application of intracavity adaptive mirror for CW solid state laser radiation control</title> (1994)

A reduction of the divergence of a laser beam by a factor of 2 - 2.5 was achieved in a multimode regime of laser generation using an intracavity controlled mirror. It is shown that various radiation mode structures may be formed at the laser output and in the far-field zone. The correspondence between the shape of a deformed flexible mirror and the configuration of a generated mode has been detected.
Lipids from Wastewater‐Activated Sludge Cultivated on Acetic Acid as Potential Alternatives to High‐Value Oils and Fats (2019)

Abstract This study focuses on new interpretations of the published literature by statistically evaluating the potential of microbial lipids from activated sludge (AS) as alternatives to high‐value oils and fats. There are two data analysis stages involved in this study after compilation and organization of fatty acid profiles from the literature databases: (1) comparison of fatty acid profiles of the cultivated AS lipids with that of oils and fats found in the literature databases, and (2) hierarchical cluster analysis of the fatty acids of the combined dataset of literature oils and fats, and the AS lipids. Results show that fatty acid profiles of lipids from cultivated AS were similar to the fatty acid profiles of some oils and fats of plant, animal, single‐microbial cultures, and algal origins; hence, lipids from AS could be potential alternatives to specialty oils and fats. The cultivation conditions of AS during lipid content enhancement may influence lipid application.
Molecular Mechanisms Governing Tumor‐Necrosis‐Factor‐Mediated Regulation of Plasminogen‐Activator Inhibitor Type‐2 Gene Expression (1996)

Plasminogen-activator inhibitor type 2 (PAI-2), a serine protease inhibitor involved in the regulation of urokinase-dependent proteolysis, is also implicated in the inhibition of tumor-necrosis-factor-(TNF)-mediated apoptosis. The PAI-2 gene is one of the most TNF-responsive genes known and is also highly induced by the phorbol ester phorbol 12-myristate 13-acetate (PMA) and the phosphatase inhibitor, okadaic acid, in both HT-1080 fibrosarcoma and U-937 histiocytic cells. We sought to identify and characterize regulatory cis-acting DNA elements and trans-acting factors which mediate basal and inducible PAI-2 gene transcription. A series of promoter deletion mutants (nucleotides -1859 to -91) fused to the chloramphenicol acetyl transferase (CAT) reporter gene were transfected into HT-1080 cells. Two repressor regions were identified; one distally between positions -1859 and -1100, and one proximally between positions -259 and -219. Cells transfected with constructs harboring more than 259 bp promoter sequence produced a 10-15-fold increase in CAT activity when treated with PMA or okadaic acid, but produced only a minimal (2.5-fold) increase in response to TNF. Removal of the proximal repressor by deletion to position -219, or by internal deletion from the -1100 PAI-2 CAT construct, resulted in a selective increase in TNF responsiveness, suggesting that induction of PAI-2 gene transcription by TNF is associated with derepression. Detailed analysis of the proximal repressor utilizing the electrophoretic mobility shift assay (EMSA), identified two novel and distinct protein-binding sites (A and B). Site A is located within the 40-bp proximal repressor while site B is situated immediately adjacent to the 3' boundary. Treatment of cells with PMA or okadaic acid produced no change in the binding activity of proteins recognising sites A or B. However, treatment of cells with TNF results in a profound selective reduction in site-B-binding activity, suggesting that this site plays a significant role in TNF-mediated regulation of PAI-2 gene expression. Our findings suggest that TNF-mediated induction of PAI-2 gene expression involves derepression and is associated with cis-acting and trans-acting factors located within and adjacent to the proximal repressor region.
RETRACTED: Construction on teaching evaluation index system of track and field general course for physical education major in light of wireless network technology (2019)

This article has been retracted. A retraction notice can be found at https://doi.org/10.3233/JIFS-219434 .
The Lewis Acid Catalysed Addition of 1-Trimethylsilyl Nitropropanate to Imines (2000)

The scandium triflate catalysed addition of 1-trimethylsilyl nitropropanate to aryl and alkyl imines is described. The use of N-(4-methoxyphenyl)imines gave superior yields and/or diastereoselectivities of β-nitro amines in most cases examined. The product β-nitro amines can be readily manipulated to 1,2-diamines by samarium diiodide reduction, formation of the cyclic urea and removal of the 4-methoxyphenyl group with ceric ammonium nitrate.
Rhodium-catalyzed reaction of diazoquinones with allylboronates to synthesize allylphenols (2022)

A rhodium-catalyzed reaction of diazoquinones and allylboronates was developed, which provides access to a range of substituted allylphenols under mild conditions.
Internal Waves in the Arctic: Influence of Ice Concentration, Ice Roughness, and Surface Layer Stratification (2018)

Abstract The Arctic ice cover influences the generation, propagation, and dissipation of internal waves, which in turn may affect vertical mixing in the ocean interior. The Arctic internal wavefield and its relationship to the ice cover is investigated using observations from Ice‐Tethered Profilers with Velocity and Seaglider sampling during the 2014 Marginal Ice Zone experiment in the Canada Basin. Ice roughness, ice concentration, and wind forcing all influenced the daily to seasonal changes in the internal wavefield. Three different ice concentration thresholds appeared to determine the evolution of internal wave spectral energy levels: (1) the initial decrease from 100% ice concentration after which dissipation during the surface reflection was inferred to increase, (2) the transition to 70–80% ice concentration when the local generation of internal waves increased, and (3) the transition to open water that was associated with larger‐amplitude internal waves. Ice roughness influenced internal wave properties for ice concentrations greater than approximately 70–80%: smoother ice was associated with reduced local internal wave generation. Richardson numbers were rarely supercritical, consistent with weak vertical mixing under all ice concentrations. On decadal timescales, smoother ice may counteract the effects of lower ice concentration on the internal wavefield complicating future predictions of internal wave activity and vertical mixing.