gebhart/patrepeval huggingface dataset:
Intelligent alarm handling in cement plants-lessons learned from the nuclear industry (2002)

Building on work done at the Halden Reactor Project and others, an intelligent alarm module (IAM) has been developed, specifically for cement and related processes, that integrates various alarm handling techniques and provides an effective way to validate and manage alarm signals. Being fully integrated with the conventional alarm system, the IAM toolbox makes it possible to focus on the areas where the conventional alarm system does not offer a satisfactory performance.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Carbamazepine and Carbamazepine-10,11− Epoxide Inhibit Amygdala-Kindled Seizures in the Rat but Do Not Block Their Development (1987)

The effect of carbamazepine and its -10,11-epoxide on the development of amygdala-kindled seizures and on completed kindled seizures in the rat was evaluated. Neither carbamazepine (15 mg/kg) nor the -10,11-epoxide (15 mg/kg) was capable of preventing the development of amygdala-kindled seizures, although both drugs, at these doses, exerted marked anticonvulsant effects on completed kindled seizures. These data suggest that different phases of kindling are differentially responsive to pharmacological intervention. They also support the conclusion that different mechanisms underlie the acquisition and maintenance of kindled seizures.
PseudoBase++: an extension of PseudoBase for easy searching, formatting and visualization of pseudoknots (2008)

Pseudoknots have been recognized to be an important type of RNA secondary structures responsible for many biological functions. PseudoBase, a widely used database of pseudoknot secondary structures developed at Leiden University, contains over 250 records of pseudoknots obtained in the past 25 years through crystallography, NMR, mutational experiments and sequence comparisons. To promptly address the growing analysis requests of the researchers on RNA structures and bring together information from multiple sources across the Internet to a single platform, we designed and implemented PseudoBase++, an extension of PseudoBase for easy searching, formatting and visualization of pseudoknots. PseudoBase++ (http://pseudobaseplusplus.utep.edu) maps the PseudoBase dataset into a searchable relational database including additional functionalities such as pseudoknot type. PseudoBase++ links each pseudoknot in PseudoBase to the GenBank record of the corresponding nucleotide sequence and allows scientists to automatically visualize RNA secondary structures with PseudoViewer. It also includes the capabilities of fine-grained reference searching and collecting new pseudoknot information.
The hip labrum reconstruction: indications and outcomes—a systematic review (2013)

Based on the current available evidence, hip labrum reconstruction is a new technique that shows short-term improvement in patient-reported outcomes and functional scores post-operatively. The main indication for reconstruction was a deficient labrum due to previous surgical excision or irreparable tears in young patients with no significant arthritis. Long-term follow-up results with higher quality studies are still lacking based on this review.
The Metalloprotease Neprilysin Degrades and Inactivates Apelin Peptides (2016)

The apelinergic system is a mammalian peptide hormone network with key physiological roles. Apelin isoforms and analogues are believed to be promising therapeutics for cardiovascular disease. Despite extensive studies on apelin-13 degradation patterns, only one protease, angiotensin-converting enzyme 2 (ACE2), had been implicated in its physiological regulation. Through use of a peptide-based fluorescent probe, we identified the metalloprotease neprilysin (NEP, a target for Entresto used in treatment of heart failure) as an enzyme that cleaves apelin isoforms. In vitro NEP proteolysis generated fragments that lacked the ability to bind to the apelin receptor, thereby making NEP the first protease to fully inactivate apelin. The involvement of NEP in the apelinergic system contributes to the understanding of its role in cardiovascular physiology.
THE EFFECTS OF a-CHLOROHYDRIN ON THE GESTATION OF THE WISTAR RAT (Rattus norvegicus) (2019)

The investigation of the effects of a-chlorohydrin on the gestation of the wistar rat has been carried out to determine whether a-chlorohydrin could interfere with the gestation of the rat and gestation period for optimal sensitivity. Alpha-chlorohydrin was administered by gavage to three different groups of pregnant rats, namely on the first (pre-implantation period), sixth (early post-implantation period) or fourteenth (late post-implantation period) gestation day, at a single dose of 62.5; 75 and 90 mg/kg body weight. Rats were sacrificed onÂ the IS* gestation day. Number of implantations, gestation loss and post-implantation mortality were recorded. The results revealed that 75 and 90 mg/kg body weight of a-chlorohydrin significantly interfered with all the gestation periods used. For the pre-implantation group, a-chlorohydrin decreased significantly the implantation number, but increased the gestation loss as well as the post-implantation mortality compared to the control groups. For the early post-implantation and late post-implantation groups, a-chlorohydrin caused a significant increase in post-implantation mortality compared to the control groups. From these results it is concluded that a-chlorohydrin at 75 and 90 mg/kg body weight influences the gestation of the wistar rat administered during the pre-implantation period as the most sensitive gestation period. Key wordsÂ : a-chlorohydrin//tattu? norvegi'ctu/rat/pre-implantation/early post-implantation/late post-implantation/implantation/gestation loss/post-implantation mortality.
Double Balloon Enteroscopy (2005)

Purpose: To report early DBE technical experience in multiple U.S. centers. Methods: 8 experienced endoscopists in 6 tertiary care centers were trained (May. Wiesbaden, Germany) to perform DBE. Observations were documented in detail. Results: 129 patients had 164 DBE: 101 per-orally, 54 per-rectally, 6 via stoma, 3 for ERCP. Mean age was 57 (19–94). Mode of sedation: general anesthesia-52, MAC-59 and conscious sedation-53. Maneuvers: India ink injection in most patients, biopsies-49, argon plasma coagulation-21, electrocautery-7, balloon dilation-1, and polypectomy-2. Mean procedure time was 99 min (per-oral-98, ERCP-105, per-rectal-105, and per-stomal-63). Mean time of the first 47 cases was 115 min. Two methods were used to report the max distance reached per-orally: mean 389 cm numerically and distal jejunum anatomically. 30% of per-rectal exams failed to pass the ileocecal valve, whereas only 1 per-oral case could not reach the jejunum. Indications: GI bleeding/iron deficiency anemia −90 patients (70%), suspected Crohn's −12, abdominal pain −9, neuroendocrine tumor search −3, small bowel obstruction −3, facilitate ERCP in the Roux-en-Y −3, stricture dilation −1 and others. For bleeding/iron deficiency anemia, the findings were: AVM-23% (mostly treated), ulcers-8%, ulcerated masses-2%, polyps-2%, strictures-2%, and varices-1%. 88 patients had previous capsule endoscopy (CE) done, and the two tests correlated significantly (p = 0.004). 65% of CE findings were confirmed by DBE; 10% of DBE findings were missed on CE. 6 patients experienced complications: abdominal pain at 24 hours-2, aspiration pneumonia-1, presumed asymptomatic microscopic perforation-1, mucosal tear-1, and stomal perforation-1. No prolonged ileus, commonly seen after operative enteroscopy, was reported. Conclusions: Although experience has shortened procedure time, DBE is still time-consuming. DBE usually reaches the mid small bowel but a total intestinal examination is not achieved with initial endoscopist experience. The technique or instrument for per-rectal examination needs improvement for better technical success. DBE reults for bleeding/anemia directed therapy in about half of patients, and its yield is comparable to that of CE.
Use of pyrylium synthons in the synthesis of hemispherands with modified cavities. X-ray structures of the 21-hemispherand and a pyrido hemispherand (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUse of pyrylium synthons in the synthesis of hemispherands with modified cavities. X-ray structures of the 21-hemispherand and a pyrido hemispherandPieter J. Dijkstra, Herman J. Den Hertog Jr., Bart J. Van Steen, Sietze Zijlstra, Maria Skowronska-Ptasinska, David N. Reinhoudt, Johan Van Eerden, and Sybolt HarkemaCite this: J. Org. Chem. 1987, 52, 12, 2433–2442Publication Date (Print):June 1, 1987Publication History Published online1 May 2002Published inissue 1 June 1987https://pubs.acs.org/doi/10.1021/jo00388a018https://doi.org/10.1021/jo00388a018research-articleACS PublicationsRequest reuse permissionsArticle Views550Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
In Situ Estuarine and Marine Toxicity Testing: A Review, Including Recommendations for Future Use in Ecological Risk Assessment (2009)

Abstract : This report reviews the advantages and limitations of in situ estuarine and marine toxicity testing strategies. Case studies that detail cage designs, testing strategies, and appropriateness of various species from different taxonomic groups are followed by recommendations on a strategy to assess the biological impact of potentially contaminated waste sites in the coastal environment.
80 GS/s 5.5 ENOB time‐interleaved inverter‐based CMOS track‐and‐hold (2020)

An inverter‐based track‐and‐hold circuit that merges the functions of buffering and sampling is proposed, simultaneously improving linearity, bandwidth and power efficiency when compared to state‐of‐the‐art designs. The circuit operation and its governing equations are presented, and simulation results of an 80 GS/s, 5.5 ENOB time‐interleaved prototype consuming 25 mW from a 0.7 V supply demonstrate the advantages of the proposed topology using a predictive 7 nm FinFET CMOS technology.
Mobility of Negative Ions in SuperfluidHe3 (1976)

We have found that the mobility of negative ions increases rapidly below ${T}_{c}$ in both superfluid $^{3}\mathrm{He}$ phases. The ratio $\frac{\ensuremath{\mu}}{{\ensuremath{\mu}}_{N}}$ of superfluid to normal mobility is larger in the $B$ phase than in the $A$ phase. A critical velocity consistent in magnitude with the Landau limit for pair breaking has also been observed. In the normal fluid we find a temperature-independent mobility between 30 mK and ${T}_{c}$ for all pressures between 0 and 28 bars.
Base-Promoted, Mild and Highly Efficient Conversion of Arylboronic Acids into Phenols with tert-Butyl Hydroperoxide (2013)

A mild and efficient protocol for the synthesis of phenols from arylboronic acids has been developed by using <i>tert</i>-butyl ­hydroperoxide with base as promoter. The corresponding phenols were obtained in good to excellent yields within several minutes.
Polarisation independent liquid crystal lenses and contact lenses using embossed reactive mesogens (2020)

Abstract Liquid crystal lenses have promise in optical systems owing to their tunability combined with low electrical power, cost, and weight. A good example of such a system is switchable contact lenses for the correction of age‐related presbyopia. Sufficiently large phase modulation can be done using nematic liquid crystals in a meniscus lens configuration. However, the birefringent materials are inherently polarisation dependent, usually requiring orthogonal polarisations to be focussed separately. A novel method is presented for producing polarisation independent lenses based on reactive mesogens. Results are presented for a 2‐level and 3‐level diffractive Fresnel lenses, and the promise of the technique for use in refractive lenses such as contact lenses is discussed.
Experimental and theoretical studies of dipole and quadrupole contributions to the vanadiumK-edge XANES forVOPO4⋅2H2Oxerogel (1998)

Angular dependence of the vanadium K-edge x-ray appearance near-edge structure (XANES) for the ${\mathrm{VOPO}}_{4}{\mathrm{\ensuremath{\cdot}}2\mathrm{H}}_{2}\mathrm{O}$ xerogel is thoroughly studied both experimentally and theoretically. The main attention is paid to the pre-edge fine structure (PEFS) of the spectra which was shown earlier to be a useful tool for the atomic short order investigations. Good quantitative agreement between theory and experiment obtained for both dipole and quadrupole contributions to the spectra proves validity of the calculation method developed and enables us to ascertain the nature of all the features in the PEFS's. The $p\ensuremath{-}d$ mixture effect due to distortion of the central coordination octahedron and the quadrupole transitions are proved to be the only mechanisms responsible for the PEFS formation in the case considered. We show that in order to achieve quantitative agreement between experimental and theoretical spectra, it is necessary to include the effect of atomic vibrations, which makes the forbidden transitions to molecular orbitals of the central octahedron (MOCO's) dipole allowed, and to take into account deviation of the crystal layers from the substrate plane, which is not a single crystal but a texture.
A convenient demountable cell for determining the electrophoretic velocity of microscopic particles (1966)

An inexpensive, demountable, rectangular cell which can be used to determine the electrophoretic mobilities of microscopic particles is described. Results obtained compare favourably with those obtained using a cylindrical cell. As a further application of the cell ξ potentials of transparent plastic coatings can be determined.
Dataset for studies on engineered hydrocortisone for treating orthotopic colon cancer (2020)

This dataset provides the details of the experimental data submitted in main text as well as in supplementary information for the studies related to depiction of systemic potential of chemically engineered hydrocortisone molecule for the treatment of colon cancer. We find that cationic lipid-conjugation with hydrocortisone infused a special property in the hydrocortisone derivative. Initially, the molecule acted as a potent anticancer molecule but we could not comprehend its further behaviour before this study is accomplished. We find that the molecule dissolved in minimum ethanol when dispersed in water by fast injection method, assumed self-aggregation, while maintaining positive surface charge and distinct hydrodynamic size. This enabled it to carry anticancer entities such as small molecule drugs and genes. The aggregate showed multinodal properties of not only carrying multiple cargoes but it showed a unique cancer cell-selective uptake and nuclear localization. This cancer cell-selective nuclear localisation led to down-regulation of drug metabolizable factors, thereby inducing drug sensitization in cancer cells. Our study in overall indicate that hydrocortisone, the natural glucocorticoid if properly engineered can make a viable therapeutic biomaterial for the treatment of cancer by way of sensitizing cancer cells to drugs and by cancer cell-selective delivery of both anticancer drug and gene.
Effects of Cardiac Sympathetic Nerve Stimulation on the Left Ventricular End-Systolic Pressure-Volume Relationship and Plasma Norepinephrine Dynamics in Dogs (1997)

The effects of cardiac sympathetic nerve (CSN) stimulation on the left ventricular end-systolic pressure-volume relationship (ESPVR) and plasma norepinephrine (NE) concentration in arterial blood were studied in dogs. In 12 anesthetized and open-chest dogs, left ventricular pressure and volume were measured simultaneously with a microtip catheter and a conductance catheter, respectively. The ESPVR values were constructed from pressure-volume loops during a brief occlusion of the inferior vena cava before and after a 40-sec train of electrical CSN stimulation. The slope (Emax) of the ESPVR line was significantly greater after CSN stimulation than before CSN stimulation (p < 0.05) for both right and left CSN stimulation. The increased Emax values after right and left CSN stimulation were not significantly different from each other. In 5 dogs, time courses of Emax, left ventricular systolic pressure, heart rate, and plasma NE concentration after CSN stimulation were studied. Left ventricular systolic pressure and heart rate returned to the baseline more rapidly than Emax and arterial plasma NE concentration. There was a positive, linear correlation between Emax (y) and arterial plasma NE concentration (x), shown as y = 3.3 x 10(-3)x + 3.1 (n = 30, r = 0.86, p < 0.05). These results imply that cardiac contractile enhancement is reflected in arterial plasma NE concentration in conditions in which CSN is activated.
Accurate model to predict performance of coherent optical transponder for high baud rate and advanced modulation format (2018)

Bit error rate (BER) versus optical signal to noise ratio (OSNR) characteristics determines the transmission performance for coherent optical transponder. We have developed a model to predict BER versus OSNR at various receiver optical power (ROP). The model has three parameters, which are related to BER noise floor, filter mismatching, and OSNR value without noise loading. The model is applied to high baud rate and quadrature amplitude modulation (QAM) transponders. By considering the influence of baud rate on the fitting parameters, accurate prediction of performance for coherent transponder can be achieved over various baud rates. Novel applications enabled by this model include in-field measurement of BER versus OSNR, simple abstraction of coherent transponder, accurate OSNR monitor and coherent optical channel monitor.
Down-regulation of CD55 and CD46 expression by anti-sense phosphorothioate oligonucleotides (S-ODNs) sensitizes tumour cells to complement attack (2007)

Overexpression of one or more membrane-bound complement regulatory proteins (mCRPs) protects tumour cells against complement-mediated clearance by the autologous humoral immune response and is also considered as a barrier for successful immunotherapy with monoclonal anti-tumour antibodies. Neutralization of mCRPs by blocking antibodies, enzymatic removal or cytokine-mediated down-regulation has been shown to sensitize tumour cells to complement attack. In our study we applied, for the first time, anti-sense phosphorothioate oligonucleotides (S-ODNs) to knock down the expression of the mCRPs CD55 and CD46 with the aim of exploiting complement more effectively for tumour cell damage. Potent anti-sense oligonucleotides against CD55 and CD46 were identified by screening various target sequences (n = 10) for each regulator. S-ODN anti-CD55(687) reduced CD55 protein expression up to 84% and CD46 protein expression was inhibited up to 76% by S-ODN anti-CD46(85). Reverse transcription-polymerase chain reaction (RT-PCR) analysis revealed a similar reduction of the CD55 and CD46 mRNA levels, which argues for an RNAse H-dependent anti-sense mechanism. T47D, A549 and PC3 cells, representing breast, lung and prostate carcinoma, were used for functional studies. Dependent on the particular cell line, anti-sense-based inhibition of mCRP expression enhanced complement-dependent cytolysis (CDC) up to 42% for CD55 and up to 40% for CD46, and the combined inhibition of both regulators yielded further additive effects in T47D cells. C3 opsonization of CD55/CD46-deficient tumour cells was also clearly enhanced upon mCRP suppression. Due to the clinical applicability of S-ODNs, the anti-sense approach described in this study may offer an additional alternative to improve the efficacy of antibody- and complement-based cancer immunotherapy.
Genetic and Physical Mapping of Genic Microsatellites in Barley (Hordeum vulgare L.) (2005)

Due to the availability of sequence data from large-scale EST (expressed sequence tag) projects, it has become feasible to develop microsatellite or simple sequence repeat (SSR) markers from genes. A set of 111 090 barley ESTs (corresponding to 55.9 Mb of sequence) was employed for the identification of microsatellites with the help of a PERL5 script called MISA. As a result, a total of 9 564 microsatellites were identified in 8 766 ESTs (SSR-ESTs). Cluster analysis revealed the presence of 2 823 non-redundant SSR-ESTs in this set. From these 754 primer pairs were designed and analysed in a set of seven genotypes including the parents of three mapping populations. Finally, 185 microsatellite (EST-SSRs) loci were placed onto the barley genetic map. These markers show a uniform distribution on all the linkage groups ranging from 21 markers (on 7H) to 35 markers (3H). The polymorphism information content (PIC) for the developed markers ranged from 0.24 to 0.78 with an average of 0.48. For the assignment of these markers to BAC clones, a PCR-based strategy was established to screen the "Morex"-BAC library. By using this strategy BAC addresses were obtained for a total of 127 mapped EST-SSRs, which may provide at least two markers located on a single BAC. This observation is indicative of an uneven distribution of genes and may lead to the identification of gene-rich regions in the barley genome.
THE ROLE OF MOLECULAR METHODS IN ENVIRONMENTAL BIOTECHNOLOGY (2001)

THE ROLE OF MOLECULAR METHODS IN ENVIRONMENTAL BIOTECHNOLOGYMolecular methods provide powerful new tools to analyze biological-treatment processes. Because molecular methods can be used to directly interrogate the genetic information about the microbial community, they can provide the fine detail that is impossible with the blunt, aggregated information usually obtained from the more traditional measures. Molecular methods allow us to track critical...Author(s)Bruce E. RittmannSourceProceedings of the Water Environment FederationSubjectSession 20 - Research Symposium: Molecular TechniquesDocument typeConference PaperPublisherWater Environment FederationPrint publication date Jan, 2001ISSN1938-6478SICI1938-6478(20010101)2001:15L.700;1-DOI10.2175/193864701790902789Volume / Issue2001 / 15Content sourceWEFTECFirst / last page(s)700 - 707Copyright2001Word count136