gebhart/patrepeval huggingface dataset:
Transcriptomic signatures in whole blood of patients who acquire a chronic inflammatory response syndrome (CIRS) following an exposure to the marine toxin ciguatoxin (2015)

Disruptions of innate and adaptive immune mechanisms were recorded at both the genomic and proteomic level. A disruption in the HLA-T cell receptor axis could indicate HLA haplotype sensitivity for this chronic syndrome, as noted in many autoimmune conditions. Taken together, these indicators of illness provide additional insights into pathophysiology and potential therapies.
An Advanced Power and Thermal Optimized High Density Rack Solution for Data Center Energy Efficiency (2020)

Higher computing capability, higher density and better energy efficiency have always been the goal of data centers. Cross different factors, IT equipment, specifically as server is playing the crucial role in a data center development. CPU/GPU and other hardware ingredients' computing capability keeps growth with innovated architecture and procedure upgrade, while comes along with increasing server power consumption as well as challenge for energy efficiency. Compared with conventional server system with dedicated fans and power supply units, design optimizations from rack level has been leading evolution to help data center to achieve those goals. This paper introduces an advanced rack scale power and thermal solution pilot deployed in Baidu new self-build data center. With the design, total rack power capacity is up to 36KW, which brings significant improvement for node density. Moreover,48V power distribution is implemented for better rack power efficiency, and centralized power shelf design with dual-input power source halves total PSU quantity for rack space saving and node density increase. Thermal solution is addressed from rack level as well, centralized fan wall provides air flow for whole rack, and thermosyphon heatsink is implemented in each node from higher heat dissipate efficiency perspective. With all the advanced technology integrated and optimized together, detailed energy efficiency contribution to Total Cost Ownership (TCO) is summarized and compared with conventional rack design and shows the advantages for data center energy efficiency.
Multidetector CT des Herzens: Erste Klinische Anwendung einer retrospektiv EKG-gesteuerten Spirale mit optimierter zeitlicher und örtlicher Auflösung zur Darstellung der Herzkranzgefäße (2000)

Fast multi-slice spiral CT with retrospectively ECG-gated spiral reconstruction is well suited for three-dimensional and functional imaging of the heart, especially for high-resolution imaging of calcified coronary plaques and CT-angiography of the coronary arteries.
Therapeutic Potential of Vitamin B 1 Derivative Benfotiamine From Diabetes to COVID-19 (2022)

Benfotiamine (S-benzoylthiamine-O-monophosphate), a unique, lipid-soluble derivative of thiamine, is the most potent allithiamine found in roasted garlic, as well as in other herbs of the genus <i>Allium</i>. In addition to potent antioxidative properties, benfotiamine has also been shown to be a strong anti-inflammatory agent with therapeutic significance to several pathological complications. Specifically, over the past decade or so, benfotiamine has been shown to prevent not only various secondary diabetic complications but also several inflammatory complications such as uveitis and endotoxemia. Recent studies also demonstrate that this compound could be used to prevent the symptoms associated with various infectious diseases such as HIV and COVID-19. In this review article, the authors discuss the significance of benfotiamine in the prevention of various pathological complications.
High-intensity CO_2 laser pumping of a CH_3F Raman FIR laser (1979)

Fifteen new, Raman far-infrared (FIR) laser emission lines in CH(3)F have been excited by optically pumping up to 24 GHz off resonance with high-intensity CO(2) TEA laser radiation (up to 20 MW/cm(2)). Most of these new lines are produced with high quantum efficiency in a waveguide laser system. High-intensity laser pumping could also be applied to other gases to produce many new, efficient lines. The present results suggest that a nearly continuously tunable source of FIR radiation in the 175-500-microm range could be obtained through Raman laser emission in CH(3)F using a tunable, multiatmospheric CO(2) pump laser.
THE QUALITY OF LIFE IN RENAL TRANSPLANTATION—A PROSPECTIVE STUDY (1992)

Methodologically sound measures of quality of life are required to judge accurately the impact of successful renal transplantation on patient well-being. The time trade-off (TTO) method is a reproducible and valid measure which we used to prospectively assess changes in the quality of life of 27 patients on maintenance dialysis who subsequently underwent renal transplantation. TTO scores approaching 0 signify a very poor quality of life, while scores approaching 1 represent perfect health. Of 98 dialysis patients who completed baseline TTO interviews, 31 consecutive patients subsequently received 28 cadaveric and 3 living related kidney transplants. Four of 31 patients did not complete a second TTO assessment, because of death in 2 patients and graft loss in 2 others. The remaining 27 patients completed a second TTO interview an average of 30.9 months following transplantation (range 1.5-52, 95% confidence interval [CI] 24.4-37.5) and formed the study cohort. At the time of study the mean serum creatinine for the cohort was 173 mumol/L (range 90-290, 95% CI 152-195 mumol/L). The employment rate rose 27% following transplantation (P = 0.10); but when males alone were analyzed, a significant increase of 38% (P = 0.048) was noted. During the dialysis period, the mean baseline TTO score was 0.41 (95% CI 0.33-0.49), confirming the observations of others. Following transplantation, the mean TTO score rose to 0.74 (95% CI 0.67-0.81), a difference that is statistically significant (P < 0.001). The mean increase in TTO score observed as a result of successful transplantation was 0.33 (95% CI 0.26-0.40). This magnitude of improvement was found in 20 of 27 patients (74%), whose TTO scores lay within or above the 95% CI (0.26-0.40) for the mean change in score of 0.33. One patient's score fell, while the remaining 6 patients had improvements in their TTO score which fell below the lower 95% CI value (0.26) for the mean change in score. We conclude that the 95% CI of 0.26-0.40 identifies a range in which clinically important improvements in quality of life will be found for the majority of patients receiving successful kidney transplants.
Local indicators of geocoding accuracy (LIGA): theory and application (2009)

Three results are significant. First, the shape of the probability distributions of positional error (e.g. circular, elliptical, cross) has little impact on the perturbability of spatial weights, which instead depends on the mean positional error. Second, our methodology allows researchers to evaluate the sensitivity of spatial statistics to positional accuracy for specific geographies. This has substantial practical implications since it makes possible routine sensitivity analysis of spatial statistics to positional error arising in geocoded street addresses, global positioning systems, LIDAR and other geographic data. Third, those locations with high perturbability (most sensitive to positional error) and high leverage (that contribute the most to the spatial weight being considered) will benefit the most from increased positional accuracy. These are rapidly identified using a new visualization tool we call the LIGA scatterplot.Herein lies a paradox for spatial analysis: For a given level of positional error increasing sample density to more accurately follow the underlying population distribution increases perturbability and introduces error into the spatial weights matrix. In some studies positional error may not impact the statistical results, and in others it might invalidate the results. We therefore must understand the relationships between positional accuracy and the perturbability of the spatial weights in order to have confidence in a study's results.
Titanium Alloys for Oil and Gas Service: a Review (2009)

Abstract There is currently significant interest in titanium alloys for downhole tubulars and components for corrosive oil and gas wells due to their combination of strength, density and corrosion resistance. These alloys may be able to augment the current list of commonly used materials available to resist corrosion and stress corrosion cracking in hostile service environments, especially for high pressure high temperature (HPHT) well applications. However, there has been only limited service experience with titanium alloys under harsh conditions of H2S, CO2, brine and elemental sulfur. Moreover, little data exists for non-production environments such as those used in concentrated brine workover/completion fluids and strong acids used in well stimulation. This paper will provide a review the results of published studies developed over the past 25 years for titanium alloys and will focus on their composition, metallurgical processing, corrosion and performance.
Endothelial-T cell crosstalk contributes to vascular injury in fatty liver disease (2021)

Abstract Cardiovascular complications are often the fundamental causes of death in non-alcoholic fatty liver disease (NAFLD) patients. While there are known systemic mediators in NAFLD that may induce vascular inflammation, the mechanism of endothelial dysfunction remain understudied. In this work, we harnessed the replicative potential of blood outgrowth endothelial cells (BOECs) to develop personalized cell lines from NAFLD patients and healthy controls. Our transcriptomic analysis showed that the top interactome network enriched in NAFLD BOECs comprised of several C-C and C-X-C chemokine ligands involved in immune cell chemotaxis. We previously reported T cell infiltration in mouse model of non-alcoholic steatohepatitis, and here, we confirmed enhanced endothelial chemokine signatures in arterial histological sections. To elucidate endothelial-immune crosstalk, we performed single-cell analysis on human peripheral blood mononuclear cells and found T cell intensification in NAFLD patients compared to healthy controls. Our immunoprofiling by flow cytometry further revealed that NAFLD patients possessed higher levels CD8+ memory cells. Functionally, T cells, instead of monocytes, adhered more pronouncedly to NAFLD BOECs. In evaluating the CXCL12-CXCR4 axis in chemotaxis, CXCR4 antagonist (AMD3100) substantially modulated the migration of patient-derived CD8+ T cells towards NAFLD BOECs, which was not observed in healthy endothelial-T cell chemotaxis coculture. Finally, we validated NAFLD-associated endothelial dysfunction by enumerating two folds more circulating endothelial cells, a biomarker of vascular injury, in the blood samples of NAFLD patients than healthy controls. Our work provides insights for translation to restore blood vessel health and potentially mitigate adverse vascular events in NAFLD. Funding Acknowledgement Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Industrial Alignment Fund Pre-Positioning grant from the Agency for Science, Technology and Research, Singapore Endothelial-T cell crosstalk in NAFLD
Infection with Trypanosoma cruzi Restricts the Repertoire of Parasite-Specific CD8+ T Cells Leading to Immunodominance (2008)

Interference or competition between CD8(+) T cells restricted by distinct MHC-I molecules can be a powerful means to establish an immunodominant response. However, its importance during infections is still questionable. In this study, we describe that following infection of mice with the human pathogen Trypanosoma cruzi, an immunodominant CD8(+) T cell immune response is developed directed to an H-2K(b)-restricted epitope expressed by members of the trans-sialidase family of surface proteins. To determine whether this immunodominance was exerted over other non-H-2K(b)-restricted epitopes, we measured during infection of heterozygote mice, immune responses to three distinct epitopes, all expressed by members of the trans-sialidase family, recognized by H-2K(b)-, H-2K(k)-, or H-2K(d)-restricted CD8(+) T cells. Infected heterozygote or homozygote mice displayed comparably strong immune responses to the H-2K(b)-restricted immunodominant epitope. In contrast, H-2K(k)- or H-2K(d)-restricted immune responses were significantly impaired in heterozygote infected mice when compared with homozygote ones. This interference was not dependent on the dose of parasite or the timing of infection. Also, it was not seen in heterozygote mice immunized with recombinant adenoviruses expressing T. cruzi Ags. Finally, we observed that the immunodominance was circumvented by concomitant infection with two T. cruzi strains containing distinct immunodominant epitopes, suggesting that the operating mechanism most likely involves competition of T cells for limiting APCs. This type of interference never described during infection with a human parasite may represent a sophisticated strategy to restrict priming of CD8(+) T cells of distinct specificities, avoiding complete pathogen elimination by host effector cells, and thus favoring host parasitism.
Investigation and Greenhouse Heat Loss based on Areas and Weather Information (2018)

In this study, eleven major coastal areas were selected and the climate environment and the greenhouse direction were analyzed. This research investigates the greenhouse heat loss according to the wind environment at target areas. The target areas were selected based on heated greenhouse cultivation area and wind environment standard. Temperature, wind speed, and wind direction among weather data for 30 years were collected and analyzed. The data were divided into the minimum, average, and maximum temperatures and the Meteorological Agency criteria applied to the weather and wind direction criteria. Data were collected in the range of 0~180 o considering the symmetry of the shape of the greenhouse. In addition, the wind direction is different for each region and the applied wind direction can be different when referring to the longitudinal direction of the greenhouse and the data are collected in the range of 0~90 o . The results of this study are expected to be used to calculate the heating load of greenhouse installed in places wind speed high.
The Transfer of Immunity from Mother to Child (2003)

The newborn's immune system grows fast from a small size at birth by exposure primarily to the intestinal microflora normally obtained from the mother at and after birth. While building up its immune system, the infant is supported by the transplacental IgG antibodies, which also contain anti-idiotypic antibodies, possibly also actively priming the offspring. The second mode of transfer of immunity occurs via the milk. Numerous major protective components, including secretory IgA (SIgA) antibodies and lactoferrin, are present. The breastfed infant is better protected against numerous common infections than the non-breastfed. Breastfeeding also seems to actively stimulate the infant's immune system by anti-idiotypes, uptake of milk lymphocytes, cytokines, etc. Therefore, the breastfed child continues to be better protected against various infections for some years. Vaccine responses are also often enhanced in breastfed infants. Long-lasting protection against certain immunological diseases such as allergies and celiac disease is also noted.
Comfort air-conditioning control for building energy-saving (2002)

In buildings such as offices and department stores, the requirement is that the room air-conditioning control system has to provide a comfortable thermal feeling for the inhabitant. While energy saving may sometime conflict with comfort, it is possible to eliminate the wasteful use of energy associated its overuse without prejudice to comfort. The basic concept is that the target set values for the room temperature should be changed dynamically so as to suit the constantly changing room environment. This paper shows that the well-known comfort index PMV is useful to air-conditioning control systems aimed at both energy-saving and comfort.
Flexible Wireless System: Unified Wireless Platform for a Wide Variety of Wireless Systems (2011)

A flexible wireless system (FWS) is a unified wireless platform which simultaneously deals with various types of wireless signals. The FWS consists of flexible access points (distributed remote stations) and flexible signal processing unit (central station). Various types of radio wave data is recei
Land subsidence of clay deposits after the Tohoku-Pacific Ocean Earthquake (2015)

Abstract. Extensive infrastructure collapse resulted from the cataclysmic earthquake that struck off the eastern coast of Japan on 11 March 2011 and from its consequent gigantic tsunami, affecting not only the Tohoku region but also the Kanto region. Among the geological and geotechnical processes observed, land subsidence occurring in both coastal and inland areas and from Tohoku to Kanto is an extremely important issue that must be examined carefully. This land subsidence is classifiable into three categories: (i) land sinking along the coastal areas because of tectonic movements, (ii) settlement of sandy deposits followed by liquefaction, and (iii) long-term post-earthquake recompression settlement in soft clay caused by dissipation of excess pore pressure. This paper describes two case histories of post-earthquake settlement of clay deposits from among the three categories of ground sinking and land subsidence because such settlement has been frequently overlooked in numerous earlier earthquakes. Particularly, an attempt is made to propose a methodology for predicting such settlement and for formulating remedial or responsive measures to mitigate damage from such settlement.
Fiber structure to convert a Gaussian beam to higher-order optical orbital angular momentum modes (2012)

We propose a fiber structure of a square core and ring refractive index profile that converts an input circular polarized Gaussian mode into optical orbital angular momentum (OAM) modes. By breaking the circular symmetry of the waveguide, the input circularly polarized fundamental mode in the square core can be coupled into the ring region to generate higher-order OAM modes, corresponding to the transference of spin angular momentum and orbital angular momentum. We show, by using simulation, the generation of OAM modes with a topological charge l up to 9 using <10 mm long fiber. The mode purity is above 96.4% and the extinction ratio can be 30 dB.
Electron Transfer Reactions of Self-Assembled Monolayers of Thio(Phenylacetylene)n-Substituted Chiral Metal−Salen Complexes (2002)

This paper describes immobilization of salen ligands in self-assembled monolayers (SAMs) on gold surfaces. The two salen ligands were attached to the gold surface via thio(phenylacetylene)n (n = 1, 2) substituents. The resulting SAMs have been analyzed using ellipsometry and X-ray photoelectron spectroscopy. These measurements showed that high-density monolayers formed on the gold surface (0.20 and 0.30 nmol/cm2 for n = 1 and 2, respectively). MnIIICl, CoIIICl, and FeIIICl were incorporated in the core of the salen ligands immobilized on a gold electrode. The electron-transfer reactions of these metal−salen monolayers were studied by cyclic voltammetry in tetrahydrofuran, and reversible redox reactions between MIII and MII (M = Mn, Co, and Fe) were observed under anaerobic conditions. In the presence of oxygen, the Mn−salen complex underwent an irreversible two-electron reduction. The coverage of the electroactive metal−salen complexes varied from 0.04 to 0.18 nmol/cm2 depending on the metal. For all three metals, higher coverage values were obtained for the longer (phenylacetylene)n linker (n = 2) than for the shorter (n = 1).
Peripheral Vascular Malformations: Imaging, Treatment Approaches, and Therapeutic Issues (2005)

Peripheral vascular malformations are now described according to some accepted guidelines, and the principle of proper treatment (nidus ablation) is becoming clear. An appropriate classification scheme for vascular anomalies and definite indications for treatment are important to successful treatment overall. The findings from noninvasive imaging (ie, Doppler ultrasonography, computed tomography, or magnetic resonance imaging) in association with clinical findings are critical in establishing the diagnosis, evaluating the extent of the malformation, and planning appropriate treatment. Direct opacification of the nidus is useful, not only in making a correct diagnosis, but also in treating the lesion with sclerotherapy. In most cases, conservative treatment is recommended, but when a patient suffers clinical complications (eg, ulceration, pain, hemorrhage, cardiac failure, or unacceptable cosmetic consequences), the nidus sclerotherapy becomes mandatory. If the vascular malformation has blood outflow to a drainage vein during nidus opacification, flow control (with balloon occlusion, tourniquet, or embolization) is necessary to achieve sclerosant stasis within the nidus. Embolotherapy (with a coil, n-butyl cyanoacrylate, or small particles) should be used for subsequent multifaceted palliative therapy. A multi-disciplinary approach is needed in the treatment of a high-flow lesion, and a dedicated team approach is necessary for appropriate management in most cases.
An $H_\\infty$ observer for descriptor nonlinear systems with nonlinear output equations (2018)

This paper deals with the problem of $H_\infty$ observer design for a class of descriptor nonlinear systems with nonlinear output measurements. The established result is broad and can be applied to many estimation problems in nonlinear systems, such as unknown input estimation, fault diagnosis and state estimation. Based on the introduction of new assumptions involving a rank condition that specifies a constraint between the numbers of allowed unknown inputs, nonlinear functions, states and the number of measurements, a new Linear Matrix Inequality condition (LMI) for observer design is proposed. The obtained LMI is more general and less conservative, from a feasibility point of view, than those existing in the literature.
Crystal structure of the antigen-binding fragment of a monoclonal antibody specific for the multidrug-resistance-linked ABC transporter human P-glycoprotein (2016)

P-glycoprotein (P-gp) is a polyspecific ATP-dependent transporter linked to multidrug resistance in cancers that plays important roles in the pharmacokinetics of a large number of drugs. The drug-resistance phenotype of P-gp can be modulated by the monoclonal antibody UIC2, which specifically recognizes human P-gp in a conformation-dependent manner. Here, the purification, sequence determination and high-resolution structure of the Fab fragment of UIC2 (UIC2/Fab) are reported. Purified UIC2/Fab binds human P-gp with a 1:1 stoichiometry. Crystals of UIC2/Fab are triclinic (space group P1), with unit-cell parameters a = 40.67, b = 44.91, c = 58.09 Å, α = 97.62, β = 99.10, γ = 94.09°, and diffracted X-rays to 1.6 Å resolution. The structure was determined by molecular replacement and refined to 1.65 Å resolution. The asymmetric unit contains one molecule of UIC2/Fab, which exhibits a positively charged antigen-binding surface, suggesting that it might recognize an oppositely charged extracellular epitope of P-gp.