gebhart/patrepeval huggingface dataset:
SmartSenior &ndash; Intelligent Services for Senior Citizens (2012)

SmartSenior is the largest Ambient Assisted Living research project in Germany, and is scheduled to run from 2009 to 2012. It aims to develop technologically innovative services that will enable older people to continue living in their own homes for longer, and stay independent for longer. SmartSenior is oriented to customers' needs for safety, health, and independence as well as optimum usability. Appliances and services from Ambient Assisted Living (AAL) and (tele-)medicine are integrated into an overall concept to create a comprehensive, modular solution. Research also focuses on the development of role and business models promising effective exploitation and on general issues such as privacy protection and sustainability of AAL services. Selected aspects and current research results of SmartSenior are presented in this article.
Development of a Closed-loop Resonant Fatigue Testing Methodology and Experimental Life Test of Aluminum Alloy (2010)

A vibration-based testing methodology is presented that assesses fatigue behavior of material for metallic structure.To minimize the testing duration, the test setup is designed for a base-excited multiple-specimen arrangement driven in a highfrequency resonant mode, which allows completion of fatigue testing in an accelerated period.A high performance electro-dynamic exciter (shaker) is used to generate harmonic oscillation of cantilever beam specimens, which are clasped on the shaker armature with specially-designed clamp fixtures.The shaker operates in closed-loop control with dynamic specimen response feedback provided by a scanning laser vibrometer.A test coordinator function is developed to synchronize the shaker controller and the laser vibrometer, and to complete the closed-loop scheme: the test coordinator monitors structural health of the test specimens throughout the test period, recognizes change in specimen dynamic behavior due to fatigue crack initiation, terminates test progression, and acquires test data in an orderly manner.Topological design is completed by constructing an analytical model and performing finite element analysis for the specimen and fixture geometry such that peak stress does not occur at the clamping fixture attachment points.Experimental stress evaluation is conducted to verify the specimen stress predictions.A successful application of the experimental methodology is demonstrated by validation tests with aluminum specimens subjected to fully-reversed bending stress.
Amorphous Semiconductor Superlattices (1983)

A new class of semiconductor superlattice materials consisting of alternating layers 8-1200-\AA{} thick has been synthesized from semiconductors such as $a\ensuremath{-}\mathrm{Si}:\mathrm{H}$, $a\ensuremath{-}\mathrm{Ge}:\mathrm{H}$, $a\ensuremath{-}\mathrm{Si}{\mathrm{N}}_{x}:\mathrm{H}$, and $a\ensuremath{-}{\mathrm{Si}}_{1\ensuremath{-}x}{\mathrm{C}}_{x}:\mathrm{H}$. X-ray diffraction, photoconductivity, and photoluminescence measurements indicate that the layers are smooth on an atomic scale, and that the interfaces are essentially defect free. Changes in the optical absorption and photoluminescence as a function of layer thickness in $a\ensuremath{-}\mathrm{Si}:\mathrm{H}/a\ensuremath{-}\mathrm{Si}{\mathrm{N}}_{x}:\mathrm{H}$ superlattices are interpreted as quantum size effects.
BCL-2 family protein expression and platinum drug resistance in ovarian carcinoma (2000)

The expression of the BCL-2 family proteins, BCL-2, BAX, BCL(XL) and BAK have been determined in a panel of 12 human ovarian carcinoma cell lines encompassing a wide range in sensitivity to cisplatin. Whereas BAX, BCL(XL) and BAK levels did not correlate with sensitivity, there was a statistically significant inverse correlation (r = -0.81; P = 0.002) between growth inhibition by cisplatin and BCL-2 levels. In sublines possessing acquired resistance to various platinum-based drugs or across a panel of human ovarian carcinoma xenografts, there was no consistent pattern of BCL-2 expression. Two relatively sensitive lines (A2780 and CH1) have been stably transfected with bcl-2 and bcl(XL) respectively and two relatively resistant lines (A2780cisR and SKOV-3) stably transfected with bax. Overexpression of BCL-2 in A2780 cells led to resistance to cisplatin compared to the vector control when assayed at 48 h post-drug incubation but a significant increase in sensitivity at 96 h. Relative rates of apoptosis at 48- and 96-h post-cisplatin exposure mirrored the growth inhibition. There was no significant difference in sensitivity of the pair of lines by clonogenic assay. No significant changes in chemosensitivity to a variety of DNA-damaging or tubulin-interactive agents were observed in the remaining transfected lines. Taken together, these results suggest that, in human ovarian carcinoma cells, high BCL-2 levels (either naturally occurring or through gene transfection) confers a trend towards sensitivity not resistance to platinum drugs.
A Planning Framework for Persistent, Multi-UAV Coverage with Global Deconfliction (2019)

Planning for multi-robot coverage seeks to determine collision-free paths for a fleet of robots, enabling them to collectively observe points of interest in an environment. Persistent coverage is a variant of traditional coverage where coverage-levels in the environment decay over time. Thus, robots have to continuously revisit parts of the environment to maintain a desired coverage-level. Facilitating this in the real world demands we tackle numerous subproblems. While there exist standard solutions to these subproblems, there is no complete framework that addresses all of their individual challenges as a whole in a practical setting. We adapt and combine these solutions to present a planning framework for persistent coverage with multiple unmanned aerial vehicles (UAVs). Specifically, we run a continuous loop of goal assignment and globally deconflicting, kinodynamic path planning for multiple UAVs. We evaluate our framework in simulation as well as the real world. In particular, we demonstrate that (i) our framework exhibits graceful coverage given sufficient resources, we maintain persistent coverage; if resources are insufficient (e.g., having too few UAVs for a given size of the enviornment), coverage-levels decay slowly and (ii) planning with global deconfliction in our framework incurs a negligibly higher price compared to other weaker, more local collision-checking schemes. (Video: https://youtu.be/aqDs6Wymp5Q)
Nanoassembly of Polydisperse Photonic Crystals Based on Binary and Ternary Polymer Opal Alloys (2016)

Ordered binary and ternary photonic crystals, composed of different sized polymer-composite spheres with diameter ratios up to 120%, are generated using bending-induced oscillatory shearing. This viscoelastic system creates polydisperse equilibrium structures, producing mixed opaline colored films with greatly reduced requirements for particle monodispersity, and very different sphere size ratios compared to other methods of nanoassembly. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Image compression using wavelet transform and multiresolution decomposition (1996)

Schemes for image compression of black-and-white images based on the wavelet transform are presented. The multiresolution nature of the discrete wavelet transform is proven as a powerful tool to represent images decomposed along the vertical and horizontal directions using the pyramidal multiresolution scheme. The wavelet transform decomposes the image into a set of subimages called shapes with different resolutions corresponding to different frequency bands. Hence, different allocations are tested, assuming that details at high resolution and diagonal directions are less visible to the human eye. The resultant coefficients are vector quantized (VQ) using the LGB algorithm. By using an error correction method that approximates the reconstructed coefficients quantization error, we minimize distortion for a given compression rate at low computational cost. Several compression techniques are tested. In the first experiment, several 512x512 images are trained together and common table codes created. Using these tables, the training sequence black-and-white images achieve a compression ratio of 60-65 and a PSNR of 30-33. To investigate the compression on images not part of the training set, many 480x480 images of uncalibrated faces are trained together and yield global tables code. Images of faces outside the training set are compressed and reconstructed using the resulting tables. The compression ratio is 40; PSNRs are 30-36. Images from the training set have similar compression values and quality. Finally, another compression method based on the end vector bit allocation is examined.
Data from Cyclin D2–Cyclin-Dependent Kinase 4/6 Is Required for Efficient Proliferation and Tumorigenesis following Apc Loss (2023)

&lt;div&gt;Abstract&lt;p&gt;Inactivation of the &lt;i&gt;Apc&lt;/i&gt; gene is recognized as the key early event in the development of sporadic colorectal cancer (CRC), where its loss leads to constitutive activation of β-catenin/T-cell factor 4 signaling and hence transcription of Wnt target genes such as c-Myc. Our and other previous studies have shown that although cyclin D1 is required for adenoma formation, it is not immediately upregulated following Apc loss within the intestine, suggesting that proliferation following acute Apc loss may be dependent on another D-type cyclin. In this study, we investigated the expression and functional relevance of cyclin D2 following Apc loss in the intestinal epithelium. Cyclin D2 is upregulated immediately following Apc loss, which corresponded with a significant increase in cyclin-dependent kinase 4 (CDK4) and hyperphosphorylated Rb levels. Deficiency of cyclin D2 resulted in a reduction in enterocyte proliferation and crypt size within Apc-deficient intestinal epithelium. Moreover, cyclin D2 dramatically reduced tumor growth and development in &lt;i&gt;Apc&lt;sup&gt;Min/+&lt;/sup&gt;&lt;/i&gt; mice. Importantly, cyclin D2 knockout did not affect proliferation of normal enterocytes, and furthermore, CDK4/6 inhibition also suppressed the proliferation of adenomatous cells and not normal cells from &lt;i&gt;Apc&lt;sup&gt;Min/+&lt;/sup&gt;&lt;/i&gt; mice. Taken together, these results indicate that cyclin D–CDK4/6 complexes are required for the efficient proliferation of cells with deregulated Wnt signaling, and inhibiting this complex may be an effective chemopreventative strategy in CRC. Cancer Res; 70(20); 8149–58. ©2010 AACR.&lt;/p&gt;&lt;/div&gt;
Pharmacodynamic Studies on Antiaging Effects of Jianshen Kangshuai Tablets (2004)

To observe the antiaging，immunity-regulating and memory-improving actions of Jianshen Kangshuai Tablets (JKT，mainly composed of cultured Cordyceps sinensii(Berk)sacc．，Americanginseng and ants) and to compare its effects with those of the preparations containing natural Cordyceps sinensis mycelium．Mice were randomized into saline control group，aging model control，Cordyceps sinensii(Berk)sacc, group and JKT groups(high-，moderate-and low-doses)．Effects of JKT on anti-lipid peroxidation, immunity regulation and improving memory-obstruction induced by hyoscine were examined．After 28-day medication，blood levels of MDA，SOD and GSH-Px were detected；serum levels of IL-1，IL-6，IL-8，DTH and PFC were examined and macrophage phagocytosis test was carried out．The weight of body，thymus gland and spleen were measured as well as the ratio of organs and body weight．The station-jumping test was used to observe the times of memory errors．JKT could decrease the content of MDA，elevate the activities of SOD and GSH-Px，and increase the weight of thymus senescence and its ratio as well as serum levels of IL-1，IL-6，IL-8 and DTH，PFC and macrophage phagocytosis；JKT, especially in moderate dose and high does，could also reduce the times of memory errors in jumping station，the difference being significant as compared with the aging model group．The improvement of most indexes in JKT groups was superior to that in cordyceps sinensii(Berk)sacc．group．JKT has antiaging action and its therapeutic mechanism is related to counteracting lipid peroxidation， regulating immunity and improving memory．
Data from TransCONFIRM: Identification of a Genetic Signature of Response to Fulvestrant in Advanced Hormone Receptor–Positive Breast Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Fulvestrant is an estrogen receptor (ER) antagonist and an approved treatment for metastatic estrogen receptor–positive (ER&lt;sup&gt;+&lt;/sup&gt;) breast cancer. With the exception of ER levels, there are no established predictive biomarkers of response to single-agent fulvestrant. We attempted to identify a gene signature of response to fulvestrant in advanced breast cancer.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Primary tumor samples from 134 patients enrolled in the phase III CONFIRM study of patients with metastatic ER&lt;sup&gt;+&lt;/sup&gt; breast cancer comparing treatment with either 250 mg or 500 mg fulvestrant were collected for genome-wide transcriptomic analysis. Gene expression profiling was performed using Affymetrix microarrays. An exploratory analysis was performed to identify biologic pathways and new signatures associated with response to fulvestrant.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Pathway analysis demonstrated that increased EGF pathway and FOXA1 transcriptional signaling is associated with decreased response to fulvestrant. Using a multivariate Cox model, we identified a novel set of 37 genes with an expression that is independently associated with progression-free survival (PFS). TFAP2C, a known regulator of ER activity, was ranked second in this gene set, and high expression was associated with a decreased response to fulvestrant. The negative predictive value of TFAP2C expression at the protein level was confirmed by IHC.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; We identified biologic pathways and a novel gene signature in primary ER&lt;sup&gt;+&lt;/sup&gt; breast cancers that predicts for response to treatment in the CONFIRM study. These results suggest potential new therapeutic targets and warrant further validation as predictive biomarkers of fulvestrant treatment in metastatic breast cancer. &lt;i&gt;Clin Cancer Res; 22(23); 5755–64. ©2016 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Robust filter design for linear systems with parametric uncertainties via unreliable transmission channels (2012)

A robust H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">∞</sub> filter design problem for a class of uncertain discrete-time systems with possible missing measurements due to unreliable networked transmission channels is investigated. The stochastic variable, satisfying Bernoulli random binary distribution, is introduced in this work to model the missing phenomena and the corresponding filtering error dynamics with delay is subsequently induced. A set of sufficient conditions is provided for the existence of the desired filter and a robust filter design method is developed within the linear matrix inequality (LMI) framework. A numerical example is given to illustrate the effectiveness of the developed design method.
Excipient-Mediated Supersaturation Stabilization in Human Intestinal Fluids (2011)

It was the purpose of this study to investigate excipient-mediated precipitation inhibition upon induction of supersaturation of poorly water-soluble drugs in aspirated human intestinal fluids (HIF) representing both the fasted and fed state. Etravirine, ritonavir, loviride, danazol and fenofibrate were selected as model compounds. For comparative purposes, precipitation inhibition was also evaluated in simple aqueous buffer, and in intestinal simulation media representative for the fasted and fed state (FaSSIF and FeSSIF, respectively). Supersaturation was induced in the test media containing predissolved excipient (HPMC-AS, HPMC-E5, HPMC-E50, HPMC-E4M, HPMC-P and PVP) at a defined degree of supersaturation (DS = 20) using the solvent shift method. The results illustrate that cellulosic polymers can reduce the precipitation rate and stabilize supersaturation in HIF. The extent of stabilization was compound and excipient dependent but independent of the nutritional state. Whenever excipient effects were observed, the predictive value of simple buffer or FaSSIF/FeSSIF was rather limited. In general, excipient-mediated precipitation inhibition was less pronounced in HIF compared to simple aqueous buffer or FaSSIF/FeSSIF. However, excipients showing no effect in simple aqueous buffer or FaSSIF/FeSSIF also proved to be ineffective in HIF, indicating the value of these simulation media in the elimination of excipients during formulation development.
Accumulation of the myosin‐II‐spectrin complex plays a positive role in apical extrusion of Src‐transformed epithelial cells (2018)

At the initial stage of carcinogenesis, transformation occurs in single cells within the epithelium. Recent studies have revealed that the newly emerging transformed cells are often apically eliminated from epithelial tissues. However, the underlying molecular mechanisms of this cancer preventive phenomenon still remain elusive. In this study, we first demonstrate that myosin-II accumulates in Src-transformed cells when they are surrounded by normal epithelial cells. Knock-down of the heavy chains of myosin-II substantially diminishes apical extrusion of Src cells, suggesting that accumulated myosin-II positively regulates the apical elimination of transformed cells. Furthermore, we have identified β-spectrin as a myosin-II-binding protein under the coculture of normal and Src-transformed epithelial cells. β-spectrin is also accumulated in Src cells that are surrounded by normal cells, and the β-spectrin accumulation is regulated by myosin-II. Moreover, knock-down of β-spectrin significantly suppresses apical extrusion of Src cells. Collectively, these results indicate that accumulation of the myosin-II-spectrin complex plays a positive role in apical extrusion of Src-transformed epithelial cells. Further elucidation of the molecular mechanisms of apical extrusion would lead to the establishment of a novel type of cancer preventive medicine.
The Photosensitized Oxygenation of Furanoeremophilanes. II. The Preparation and Stereochemistry of the Isomeric Hydroperoxides and the Corresponding Lactones from Furanofukinin and Furanoeremophilane (1977)

Abstract The dye-sensitized oxygenation of furanofukinin, and furanoeremophilane, in methanol gave, quantitatively, crystalline mixtures of two isomeric hydroperoxides each consisting of a pair of 8α-methoxy-12β-hydroperoxy and 8β-methoxy-12α-hydroperoxy derivatives respectively. The hydroperoxides were readily transformed to the corresponding lactones with acetic anhydride-pyridine through dehydration. The stereochemistry of the hydroperoxides and the corresponding lactones has been elucidated by spectral and chemical methods according to a previously outlined generalization. Further, furanofukinin, furanoeremophilane, and 8β-hydroxyeremophilenolide, have been synthesized from petasalbin, fukinone, and an epimeric mixture of 8α- and 8β-methoxy lactones, respectively.
Osteoporosis and Osteopenia in Patients with Osteoarthritis (2016)

journal of orthopaedics is an international, peer reviewed scientific journal focused towards publishing a complete and reliable source of information on the innovations and ongoing developments in the field of Orthopedics which includes extensive study in the fields of Hand surgery.
Conservative Treatment of Bisphosphonate-Related Osteonecrosis of the Jaw in Multiple Myeloma Patients (2014)

The use of intravenous bisphosphonates (pamidronate or zoledronic acid) is the cornerstone for the management of multiple myeloma-(MM-) related bone disease. However, osteonecrosis of the jaw (ONJ) is a rare, but sometimes difficult to manage, adverse effect of bisphosphonates therapy. A retrospective review of all MM patients who were treated with bisphosphonates in our department, from 2003 to 2013, and developed ONJ was performed. According to inclusion criteria, 38 patients were studied. All these patients were treated as conservatively as possible according to the American Association of Oral and Maxillofacial Surgeons criteria. Patients were managed with observation, oral antibacterial mouth rinse with chlorhexidine, oral antibiotics, pain control with analgesics, nonsurgical sequestrectomy with or without simultaneous administration of antibiotics, or major surgery with or without antibiotics. Healing of the lesions was achieved in 23 (60%) patients who were treated with conservative measures; the median time to healing was 12 months (95% CI: 4-21). The number of bisphosphonates infusions influenced the time to healing: the median time to healing for patients who received <16 infusions was 7 months and for those with >16 infusions was it 14 months (P = 0.017). We conclude that a primarily nonsurgical approach appears to be a successful management strategy for bisphosphonate-related ONJ.
A Multidirectional Non-Cell Autonomous Control and a Genetic Interaction Restricting Tobacco Etch Virus Susceptibility in Arabidopsis (2007)

The defect in infectivity is conferred by a recessive locus. Molecular genetic analysis and complementation analysis with three alleles of a previously published mutant lsp1 (loss of susceptibility to potyviruses) indicate a genetic interaction conferring haploinsufficiency between the B149 locus and certain alleles of lsp1 resulting in impaired host susceptibility. The pattern of restriction of TEV foci on leaves at or near the boundaries of certain cell types and leaf boundaries suggest dysregulation of a multidirectional non-cell autonomous regulatory mechanism. Understanding the nature of this multidirectional signal and the molecular genetic mechanism conferring it should potentially reveal a novel arsenal in the cellular machinery.
Water Interaction with Thermally Oxidized Porous Silicon Layers (1997)

Water vapor adsorption and liquid penetration into thermally oxidized porous silicon films were studied by variable angle spectroscopic ellipsometry. Characterization of the surfaces in air combined with multilayer optical modeling showed the existence of a gradient in the volume porosity and bulk‐like silicon skeleton in the layers. Films oxidized at 300°C contained a thin oxide layer and further oxidation at 800°C resulted in an almost total oxidation of the silicon skeleton, which yielded an increased hydrophilicity and an almost complete pore filling by water both from saturated atmospheres and from a liquid phase. Total water adsorption per gram adsorbent at saturation was 0.50 cm3/g for the 300°C samples and 0.45 cm3/g for the totally oxidized films. Oxidation at 800°C resulted in a surface area of 72 m2/g determined by a modified Brunauer‐Emmett‐Teller procedure.