gebhart/patrepeval huggingface dataset:
Mechanistic Insights into Impaired Dendritic Cell Function by Rapamycin: Inhibition of Jak2/Stat4 Signaling Pathway (2004)

The suppressive effect of rapamycin on T cells has been extensively studied, but its influence on the function of APC is less clear. The data in this study demonstrated that immunostimulatory activity of B10 (H2(b)) dendritic cells (DC) exposed to rapamycin (rapa-DC) was markedly suppressed as evidenced by the induction of low proliferative responses and specific CTL activity in allogeneic (C3H, H2(k)) T cells. Administration of rapa-DC significantly prolonged survival of B10 cardiac allografts in C3H recipients. Treatment with rapamycin did not affect DC expression of MHC class II and costimulatory molecules or IL-12 production. Rapamycin did not inhibit DC NF-kappaB pathway, however, IL-12 signaling through Janus kinase 2/Stat4 activation was markedly suppressed. Indeed, Stat4(-/-) DC similarly displayed poor allostimulatory activity. The Stat4 downstream product, IFN-gamma, was also inhibited by rapamycin, but DC dysfunction could not solely be attributed to low IFN-gamma production as DC deficient in IFN-gamma still exhibited vigorous allostimulatory activity. Rapamycin did not affect DC IL-12R expression, but markedly suppressed IL-18Ralpha and beta expression, which may in turn down-regulate DC IL-12 autocrine activation.
Electron affinities of some polycyclic aromatic hydrocarbons, obtained from electron-transfer equilibria (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectron affinities of some polycyclic aromatic hydrocarbons, obtained from electron-transfer equilibriaLouis Crocker, Tiebang Wang, and Paul KebarleCite this: J. Am. Chem. Soc. 1993, 115, 17, 7818–7822Publication Date (Print):August 1, 1993Publication History Published online1 May 2002Published inissue 1 August 1993https://pubs.acs.org/doi/10.1021/ja00070a030https://doi.org/10.1021/ja00070a030research-articleACS PublicationsRequest reuse permissionsArticle Views727Altmetric-Citations108LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
RIBONUCLEOTIDE REDUCTASES (1998)

Ribonucleotide reductases provide the building blocks for DNA replication in all living cells. Three different classes of enzymes use protein free radicals to activate the substrate. Aerobic class I enzymes generate a tyrosyl radical with an iron-oxygen center and dioxygen, class II enzymes employ adenosylcobalamin, and the anaerobic class III enzymes generate a glycyl radical from S-adenosylmethionine and an iron-sulfur cluster. The X-ray structure of the class I Escherichia coli enzyme, including forms that bind substrate and allosteric effectors, confirms previous models of catalytic and allosteric mechanisms. This structure suggests considerable mobility of the protein during catalysis and, together with experiments involving site-directed mutants, suggests a mechanism for radical transfer from one subunit to the other. Despite large differences between the classes, common catalytic and allosteric mechanisms, as well as retention of critical residues in the protein sequence, suggest a similar tertiary structure and a common origin during evolution. One puzzling aspect is that some organisms contain the genes for several different reductases.
Protect right: right ventricular failure prevention strategy for left ventricular assist device implantation (2020)

Right ventricular failure imparts poor prognosis following left ventricular assist device implantation. We present a strategy for the primary prevention of right ventricular failure after left ventricular assist device implantation in a high-risk patient.
Trisintercalation in DNA by N-[3-(9-acridinylamino)propyl]-N,N-bis[6-(9-acridinylamino)hexyl]amine (1984)

Viscometry, u.v. spectroscopy, fluorescence, and flow linear dichroism of N-[3-(9-acridinylamino) propyl]-N,N-bis[6-(9-acridinylamino)hexyl]amine (1) in the presence of DNA indicate that it is trisintercalating, and that it slowly ‘crawls’ along the DNA to find its option binding site.
Solving the influence maximization problem reveals regulatory organization of the yeast cell cycle (2016)

Abstract The Influence Maximization Problem (IMP) aims to discover the set of nodes with the greatest influence on network dynamics. The problem has previously been applied in epidemiology and social network analysis. Here, we demonstrate the application to cell cycle regulatory network analysis of Saccharomyces cerevisiae. Fundamentally, gene regulation is linked to the flow of information. Therefore, our implementation of the IMP was framed as an information theoretic problem on a diffusion network. Utilizing all regulatory edges from YeastMine, gene expression dynamics were encoded as edge weights using a variant of time lagged transfer entropy, a method for quantifying information transfer between variables. Influence, for a particular number of sources, was measured using a diffusion model based on Markov chains with absorbing states. By maximizing over different numbers of sources, an influence ranking on genes was produced. The influence ranking was compared to other metrics of network centrality. Although ‘top genes’ from each centrality ranking contained well-known cell cycle regulators, there was little agreement and no clear winner. However, it was found that influential genes tend to directly regulate or sit upstream of genes ranked by other centrality measures. This is quantified by computing node reachability between gene sets; on average, 59% of central genes can be reached when starting from the influential set, compared to 7% of influential genes when starting at another centrality measure. The influential nodes act as critical sources of information flow, potentially having a large impact on the state of the network. Biological events that affect influential nodes and thereby affect information flow could have a strong effect on network dynamics, potentially leading to disease. Code and example data can be found at: https://github.com/Gibbsdavidl/miergolf Author Summary The Influence Maximization Problem (IMP) is general and is applied in fields such as epidemiology, social network analysis, and as shown here, biological network analysis. The aim is to discover the set of regulatory genes with the greatest influence in the network dynamics. As gene regulation, fundamentally, is about the flow of information, the IMP was framed as an information theoretic problem. Dynamics were encoded as edge weights using time lagged transfer entropy, a quantity that defines information transfer across variables. The information flow was accomplished using a diffusion model based on Markov chains with absorbing states. Ant optimization was applied to solve the subset selection problem, recovering the most influential nodes.The influential nodes act as critical sources of information flow, potentially affecting the network state. Biological events that impact the influential nodes and thereby affecting normal information flow, could have a strong effect on the network, potentially leading to disease.
A phase I study of pivaloyloxymethyl butyrate, a prodrug of the differentiating agent butyric acid, in patients with advanced solid malignancies. (2002)

Pivaloyloxymethyl butyrate (AN-9), an acyloxyalkyl ester prodrug of butyric acid (BA), has demonstrated greater potency than BA at inducing malignant cell differentiation and tumor growth inhibition and has demonstrated more favorable toxicological, pharmacological, and pharmaceutical properties than BA in preclinical studies. The principal objective of this study was to determine the feasibility of administering AN-9 as a 6-h i.v. infusion daily for 5 days every 3 weeks in patients with advanced solid malignancies. The study also sought to determine the principal toxicities and maximum tolerated dose of AN-9 on this intermittent schedule, as well as the effects of AN-9 on fetal hemoglobin production, a parameter indicative of RBC differentiation. None of the 28 patients treated with 85 total courses of AN-9 at dosages ranging from 0.047 to 3.3 g/m(2)/day every 3 weeks experienced dose limiting toxicity. Mild to moderate nausea, vomiting, hepatic transaminase elevation, hyperglycemia, fever, fatigue, anorexia, injection site reaction, diarrhea, and visual complaints were observed. Dose escalation of AN-9 was limited by the maximum feasible volume of its intralipid formulation vehicle that could be administered safely on this schedule, resulting in a maximum deliverable dose of 3.3 g/m(2)/day. There was no consistent increase in fetal hemoglobin with AN-9 treatment. A partial response was observed in a previously untreated patient with metastatic non-small cell lung cancer. Additional disease-directed clinical evaluations of AN-9 are necessary to establish the breadth of its antitumor activity and to assess its role as an effective differentiating agent.
Prostaglandins facilitate peptide release from rat sensory neurons by activating the adenosine 3',5'-cyclic monophosphate transduction cascade (1995)

Prostaglandins sensitize sensory neurons to activation by mechanical, thermal and chemical stimuli. This sensitization also results in an increase in the stimulus-evoked release of the neuroactive peptides, substance P and calcitonin gene-related peptide from sensory neurons. The cellular transduction cascade underlying the prostaglandin-induced augmentation of peptide release is not known. Therefore, we examined whether the sensitizing action of prostaglandins on peptide release from sensory neurons grown in culture is mediated by the second messenger, adenosine 3′, 5′ cyclic monophosphate (cAMP). Prostaglandin E2 and carba prostacyclin (a stable analog of prostaglandin I2) significantly increase the content of cAMP-like immunoreactive substance (icAMP) in the sensory neuron cultures at concentrations that also augment the bradykinin- or capsaicin-evoked release of peptides. Furthermore, pretreating sensory neurons with agents that increase intracellular cAMP mimics the sensitizing action of prostaglandins. Exposing cultures to either forskolin (0.1–10 microM), cholera toxin (1.5 micrograms), or 8-bromo-cAMP (100 microM) results in a significant enhancement of the bradykinin- or capsaicin-stimulated release of both substance P-like and calcitonin gene-related peptide-like immunoreactive substances. Pretreating sensory neurons with the adenylyl cyclase inhibitor, 9-tetrahydro-2-furyl adenine (5 mM), abolishes the prostaglandin-induced increases in icAMP content and attenuates the prostaglandin E2 or carba prostacyclin enhancement of the evoked release of calcitonin gene-related peptide-like immunoreactive substance. These results demonstrate that the cAMP transduction cascade mediates the sensitizing actions of prostaglandins on peptide release from sensory neurons.
Proceedings of the 13th International MindTrek Conference: Everyday Life in the Ubiquitous Era (2009)

It is our great pleasure to welcome you to the 13th MindTrek Conference and the International Academic Conference MindTrek from September 30th - October 2nd 2009: Everyday Life in the Ubiquitous Era.

Academic MindTrek brings together a cross-disciplinary crowd of people in order to investigate current and emerging topics within media in the ubiquitous arena. Business, social, technical and content-related media topics will be discussed this year.

The MindTrek Association hosts MindTrek as an annual conference, where the Academic MindTrek conference has been a part this unique set of events comprising competitions, world-famous keynote speakers, plenary sessions, media festivals and workshops, since 1997.

The scientific part of the conference is organized in co-operation with ACM SIGMM, and ACM SIGCHI. Conference proceedings will be published in the ACM Digital Library. Selected high quality papers will be selected and published in international journals, as book chapters, or via open access journals.
Unsteady heat transfer from a sphere at low Reynolds and Strouhal numbers (1993)

An axisymmetric formulation is employed to examine convective heat transfer from a sphere in a traveling sound wave. Time-dependent thermal displacement and induced transient flows are found to increase the minimum value for transient heat transfer significantly above the pure conduction limit. Transient effects are found to cause significant differences when compared to a quasi-steady analysis in the determination of transient convection. General trends are found for a range of low Strouhal and Reynolds numbers.
Mono- and Dianionic Guanidinate Ligands. Reactivity of [iPrNC(NiPr)2]Ta(NMe2)3 and [(iPrNH)C(NiPr)2]TaCl(NMe2)3 with Me3SiCl and ArNC (Ar = 2,6-Me2C6H4) (2000)

Reactivities of the dianionic guanidinate complex of [iPrNC(NiPr)2]Ta(NMe2)3 (1) and the monoanionic guanidinate complex Ta(NMe2)3Cl[(iPrN)2CN(H)iPr] (4) have been investigated. Reaction of 1 with Me3SiCl produced compound 2, Ta(NMe2)3Cl[(iPrN)2CN(SiMe3)iPr], which is proposed to arise from the addition of the Si−Cl bond across a Ta−N(guanidinate) bond of the starting material rather than one of the Ta−NMe2 bonds. Complex 2 is the analogue of 4 in which H has been replaced by SiMe3. Derivatization of 2 was achieved by reaction with PhCH2MgCl to produce Ta(NMe2)3(CH2Ph)[(iPrN)2CN(SiMe3)iPr] (3). The single-crystal X-ray-determined structural features of 3 are reported and support the spectroscopic characterization of 3, and indirectly that of 2, by revealing a bidentate tetrasubstituted guanidinate monoanion and an η1-benzyl group. Complexes 1 and 4 insert 2,6-dimethylphenyl isocyanide (ArNC) to yield the structurally characterized complex Ta(NMe2)[C(NiPr)3][η2-(Me2N)CN(2,6-Me2C6H3)]2 (5), which possesses one dianionic bidentate guanidinate ligand and two η2-iminocarbamoyl ligands derived from the insertion of ArNC into two of the Ta−NMe2 bonds of the starting materials. The formally seven-coordinate Ta(V) center of 5 can be viewed as pseudo trigonal bipyramidal, with each of the η2-CN linkages occupying a single coordination site. In the case of 4, the transformation of the guanidinate anion into its dianionic form was concomitant with insertion of ArNC. The sources of base for the deprotonation of the guanidinate ligand are likely the amido groups of a portion of the starting material.
The network concept of creativity and deep thinking. Applications to social opinion formation and talent support (2017)

Our century has unprecedented new challenges, which need creative solutions and deep thinking. Contemplative, deep thinking became an endangered species in our rushing world of Tweets, elevator pitches and fast decisions. Here we describe that important aspects of both creativity and deep thinking can be understood as network phenomena of conceptual and social networks. nodes occupy highly dynamic, boundary spanning positions in social networks. Creative thinking requires alternating plasticity-dominated and rigidity-dominated mindsets, which can be helped by dynamically changing social network structures. In the closing section we present three case studies which demonstrate the applications of the concept in the Hungarian research student movement, the Hungarian Templeton Program and the Youth Platform of the European Talent Support Network. These examples show how talent support programs can mobilize the power of social networks to enhance creative, deliberative, deep thinking of talented young minds, influencing social opinion, leading to community action, and developing charismatic leadership skills.
Phenotype, Body Composition, and Prediction Equations (Indian Fatty Liver Index) for Non-Alcoholic Fatty Liver Disease in Non-Diabetic Asian Indians: A Case-Control Study (2015)

Non-diabetic Asian Indians with NAFLD researched by us were overweight/obese, had excess abdominal and subcutaneous fat, multiple other phenotypic markers, had higher insulin resistance, glycemia, dyslipidemia and subclinical inflammation than those without. Prediction score developed by us for NAFLD; IFLI-C and IFLI-CB, should be useful for clinicians and researchers.
Composites from functionalized polyolefins and silica (2001)

The effect of diethyl maleate (DEM) units grafted to the polyolefins on the compatibility with inorganic fillers has been investigated. Ethylene-propylene rubber functionalized with DEM (EPR-g-DEM) was mixed with silica in different weight ratios using a Brabender mixer (Plastograph), by comparing analogous mixtures prepared starting with unmodified ethylene-propylene-rubber (EPR) and silica. The Torque traces showed that the diethyl maleate grafted on the EPR significantly changed the interfacial interaction between the silica surface and the EPR during the mixing process. Incorporation of silica into either EPR and EPR-g-DEM by mechanical mixing produced a fraction of insoluble by association with the filler (bound rubber), as revealed by the solvent extraction technique. Bound rubber evaluations pointed out the major capability of the EPR-g-DEM to interact with the mineral surface. In this case specific interactions involving the carbonyl groups of the functionalized polyolefin and the polar sites on the filler surface have been identified by means of FT-IR spectroscopy. As revealed by SEM observations, these specific interactions at the interface promote the mutual wettability and adhesion of the components in EPR-g-DEM/silica composites.
Transient model of a fluorine electrolysis cell coupling electric currents, heat transfer, two-phase flow and transport of species (2016)

International audience
New‐onset juvenile dermatomyositis. Comparisons with a healthy cohort and children with juvenile rheumatoid arthritis (1997)

Frequencies of familial autoimmune disease, exposure to environmental factors, or elevated antibody titers to T gondii, HSV, or CVB are not increased in juvenile DM. Children with juvenile DM do have symptoms of illness 3 months before the disease-onset date, and young patients have elevated enteroviral titers, as do young geographic controls.
Altered Phase Behavior in Membranes of Aging Dry Pollen May Cause Imbibitional Leakage (1994)

Aging of dry pollen has been shown to coincide with increases of free fatty acids and lysophospholipids. These compounds reduce the integrity of hydrated liposomes made from isolated pollen phospholipids but do not lead to their total destruction. However, a massive, instantaneous leakage occurs upon imbibition of dry cattail pollen (Typha latifolia) that has aged to the point of complete loss of viability. To resolve the apparent discrepancy in stability between hydrated and dry membranes, the lyotropic phase behavior of two liposome systems containing lysophospholipid (12 mol%) was studied with differential scanning calorimetry and Fourier transform infrared spectroscopy. In both systems dehydration caused phase separation of the lipids. Fourier transform infrared data concerning phase behavior of isolated membranes from aging pollen and of membranes in situ did not show phase separations, probably because the assay technique was not sufficiently sensitive to detect them. However, aging of the pollen resulted in a permanent increase in the gel-to-liquid crystalline phase transition temperature (Tm) of isolated membranes and in a broadening of the transition in situ. We conclude that the increase in Tm of hydrated membranes may be more closely related to the leakage.
Semiconductor Laser Digital Scanner (1989)

A novel semiconductor laser digital scanner composed of a monolithic semiconductor laser array and a conventional plastic lens is proposed. A high speed scanning, a simultaneous light emission, and a wide angle scanning are achieved. The semiconductor laser array consists of monolithically integrated ten index-guided 780nm emitters spaced by 0.3mm. The lens is an aspheric plastic lens which is widely used in the compact disc system with 4.5mm focal length and 0.45 N.A.. The maximum scanning angle is about 43 degrees and the beam diameter (FWHM) on a screen varies from 0.10mm to 0.53mm. Computer simulation using the ray tracing method is performed. We have found that the calculated results on the spheric lens case fit well with experimental ones using the aspheric lens.
Elevated allogeneic cytotoxic T lymphocyte activity in peripheral blood leukocytes of homosexual men. (1985)

Peripheral blood leukocytes (PBL) from male homosexual and heterosexual volunteers who did not have evidence of acquired immunodeficiency syndrome (AIDS) were studied for their ability to generate cytotoxic T lymphocyte (CTL) responses in vitro to allogeneic stimulator PBL from a single individual or from a pool of donors (allo-pool). Seventeen of 39 homosexual donors generated strong primary CTL activity to a single randomly selected stimulator donor, whereas only two of 16 heterosexual donors generated a strong CTL response to the same stimulators. A more detailed study was performed by using PBL from 11 of the homosexual and five of the heterosexual donors, in which CTL responses to the allo-pool were repeatedly tested over a 14-mo period. The response status of the donors that were strong and weak or moderate responders did not change during this period. No correlation of strength of CTL activity was observed with the following: HLA mismatching between responder and stimulator; proportion of OKT4+ and OKT8+ subsets in peripheral blood; antibodies to HTLV-III; antibody titers to hepatitis B, Epstein Barr virus, cytomegalovirus, or HLA alloantigens; homosexual practices; or circulating immune complex levels, although a statistical correlation by multivariate analysis was observed between elevated allogeneic CTL and a combination of other factors. The findings are discussed with respect to possible relevance to AIDS susceptibility and development.
Flavone Glucoside Uptake into Barley Mesophyll and Arabidopsis Cell Culture Vacuoles. Energization Occurs by H+-Antiport and ATP-Binding Cassette-Type Mechanisms (2002)

In many cases, secondary plant products accumulate in the large central vacuole of plant cells. However, the mechanisms involved in the transport of secondary compounds are only poorly understood. Here, we demonstrate that the transport mechanisms for the major barley (Hordeum vulgare) flavonoid saponarin (apigenin 6-C-glucosyl-7-O-glucoside) are different in various plant species: Uptake into barley vacuoles occurs via a proton antiport and is competitively inhibited by isovitexin (apigenin 6-C-glucoside), suggesting that both flavone glucosides are recognized by the same transporter. In contrast, the transport into vacuoles from Arabidopsis, which does not synthesize flavone glucosides, displays typical characteristics of ATP-binding cassette transporters. Transport of saponarin into vacuoles of both the species is saturable with a K(m) of 50 to 100 microM. Furthermore, the uptake of saponarin into vacuoles from a barley mutant exhibiting a strongly reduced flavone glucoside biosynthesis is drastically decreased when compared with the parent variety. Thus, the barley vacuolar flavone glucoside/H(+) antiporter could be modulated by the availability of the substrate. We propose that different vacuolar transporters may be responsible for the sequestration of species-specific/endogenous and nonspecific/xenobiotic secondary compounds in planta.