gebhart/patrepeval huggingface dataset:
Information Needs and Information Seeking Behavior of Television Media Professionals in Bengaluru: A Study (2017)

This paper provided insight into the information needs and seeking behavior of television media professionals in Bengaluru, Karnataka. The comprehensive information was obtained through a well-structured questionnaire informal interview and observation methods, which involved several aspects of media information resources usage such as awareness, frequency and place of access, awareness of the availability of information resources, learn to use, purpose and benefits, rating of electronic information resources based on their features, preferred search engines, The overall attitude towards the use of information resources among television media professional was shown to be very positive. Further, the usage of these resources can be increased if users are motivated to use these services in the media library by providing them help in searching and downloading the information. This study has served as a benchmark for the use of media information resources by the media professionals of television media in Bengaluru city, Karnataka.
Abstract LB-116: Immunodeficient pigs as a large animal model for human tumors (2012)

Abstract Currently, SCID mice are the major biomedical model for the study of human cancer and other diseases; however, they can be a poor model because there is a large discrepancy in body size and physiology between rodents and humans. Since most new anticancer drugs are first evaluated in rodents, most fail in phase I and phase II clinical trials. Thus, there is a tremendous demand for more sophisticated animal models, which may improve the translation efficiency from preclinical to clinical studies. We recently identified pigs that are severely immunocompromised. Here we tested these pigs as a model for human tumors. Three immunodeficient (ID) pigs and three normal (WT) pigs, six weeks of age, were tested for their ability to allow xenotransplanted human tumors to grow. Each pig was transplanted with 4 million A375 human malignant melanoma cells subcutaneously into the left ear and 4 million PANC-1 human pancreatic carcinoma cells subcutaneously into the right ear on day 0. The ID pigs were euthanized 6, 14, or 23 days after cell transplantation, based on their health condition. Palpable melanoma tumors were identified on day 13 after cell transplantation in the two remaining ID pigs. After euthanasia, full necropsy was performed on all pigs; tissues were collected from ears and other organs for histopathological analysis. Melanoma and pancreatic tumor xenotransplants were identified histologically in all three ID pigs. The presence of human cancer cells in these pigs was further verified with anti-human mitochondrial immunohistochemistry. No transplanted tumors were found, grossly, histologically, or immunohistochemically, in the WT pigs. We propose that this genetic line of ID pigs may prove to be a useful large animal model for human tumors. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-116. doi:1538-7445.AM2012-LB-116
Design & Implementation of JPEG2000 Encoder using VHDL (2008)

This paper deals with the design and implementation of JPEG2000 Encoder using Very High Speed Integrated Circuit Hardware Description Language (VHDL). The new still compression image standard, JPEG2000 has emerged with a number of significant features that would allow it to be used efficiently over a wide variety of images. The scalability of the new standard is intended to allow trading off between compression rates and quality of images. Due to multi-resolution nature of wavelet transforms, they have been adopted by the JPEG2000 standard as the transform of choice. In this paper, an implementation for a reconfigurable fully scalable Integer Wavelet Transform (IWT) unit that satisfies the specifications of the JPEG2000 standard has been presented. The implementation is based on the lifting scheme, which is the most computation efficient implementation of the discrete wavelet transform.
Aminoquinoline Derivatives as HCV Inhibitors (2013)

ADVERTISEMENT RETURN TO ISSUEPREVPatent HighlightNEXTAminoquinoline Derivatives as HCV InhibitorsJean-Francois Brazeau† and Gerard Rosse*†‡View Author Information† Structure Guided Chemistry, Dart Neuroscience LLC, 7473 Lusk Boulevard, San Diego, California 92121, United States‡ Adjunct Associate Professor, Department of Pharmacology and Physiology, College of Medicine, Drexel University, New College Building, 245 North 15th Street, Philadelphia, Pennsylvania 19102, United States*E-mail: [email protected]Cite this: ACS Med. Chem. Lett. 2014, 5, 3, 225Publication Date (Web):September 24, 2013Publication History Received18 September 2013Published online24 September 2013Published inissue 13 March 2014https://pubs.acs.org/doi/10.1021/ml4003748https://doi.org/10.1021/ml4003748editorialACS PublicationsCopyright © 2013 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views685Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (218 KB) Get e-AlertscloseSUBJECTS:Antimicrobial agents,Assays,Infectious diseases,Inhibitors,Reaction products Get e-Alerts
A positively Tuned Voltage Indicator Reveals Electrical Correlates of Calcium Activity in the Brain (2021)

Abstract Neuronal spiking activity is routinely recorded using genetically encoded calcium indicators (GECIs), but calcium imaging is limited in temporal resolution and does not report subthreshold voltage changes. Genetically encoded voltage indicators (GEVIs) offer better temporal resolution and subthreshold sensitivity, but spike detection with fast GEVIs has required specialized imaging equipment. Here, we report the ASAP4 subfamily of genetically encoded voltage indicators (GEVIs) that brighten in response to membrane depolarization, inverting the fluorescence-voltage relationship of previous ASAP GEVIs. Two variants, ASAP4b and ASAP4e, feature 128% and 178% fluorescence increases over 100-mV of depolarization, respectively, facilitating spike detection in single trials in vivo with standard 1 and 2-photon imaging systems. Simultaneous voltage and calcium imaging confirms improved temporal resolution and spike discernment by ASAP4 GEVIs. Thus, positively tuned ASAP4 voltage indicators enable recording of neuronal spiking activity using similar equipment as calcium imaging, while providing higher temporal resolution. One Sentence Summary Upward ASAPs increase detection capability of GEVIs in vivo .
Capillary electrophoresis and isoelectric focusing in peptide and protein analysis (2012)

CZE and CIEF of proteins have preceded, and accompanied, the birth of proteomics. Although they might not be fully exploited in massive proteomic analyses (especially those projects aiming at a deep discovery of possibly the entire proteome of a cell or subcellular organelles or biological fluids), it still has interesting features and advantages, especially with samples of limited heterogeneity and in the field of purity checking for recombinant DNA proteins meant for human consumption. The purpose of this tutorial paper is to guide the reader through the history of the field, then through the main steps of the process, from sample preparation to analysis of proteins and peptides, while commenting on the constraints and caveats of the technique. The tutorial ends with an outlook on the future, which might be dominated by microchip electrophoresis, especially for ultrafast analyses of protein samples in a sieving mode, in presence of either sieving liquid polymers or firm gels polymerized within the microchannels. To this purpose, commercial instrumentation is already available on the market. This tutorial is part of the International Proteomics Tutorial Programme (IPTP 13).
New Compensation Principles for Enhanced Image Quality in Industrial Radiology with Digital Detector Arrays (2009)

Contrast-to-noise ratio (CNR) management is the key element for image quality control in digital radiology. Modern digital detector array calibration techniques allow an extraordinary increase of CNR in comparison to other digital detectors and film. Contrast reduction due to an increase in X-ray energy can be overcompensated for by noise reduction. This enables the reduction of acquisition time and increase of the thickness range per radiograph. Even limitations in the spatial resolution, constrained by the individual picture element (pixel) size of the detector, can be compensated for with an increased CNR. Bad pixel management of digital detector arrays in combination with CNR enhancement enables the safe application of this technology for film replacement. Considering these points, three compensation principles have been formulated for the implementation of digital detector arrays as a viable film replacement technology. The first is compensation of reduced contrast (μ eff ) by increased signal-to-noise ratio (SNR): if optimization of contrast cannot be achieved, the noise must be reduced (increased SNR); if contrast can be increased, there is more tolerance for higher noise (moderate or lower SNR can be used). The second is compensation of insufficient detector sharpness (high unsharpness) by increased SNR. The third is compensation of interpolation unsharpness due to bad pixel correction by increased SNR.
Analysis of Organisms Surviving in Highly Contaminated Environments (2004)

Author(s): Wyborski, Denise L.; Abulencia, Carl B.; Buchner, Bob; Burton, Darren; Chang, Cathy; Garcia, Joe; Hazen, Terry C.; Obokata, Keiko; Podar, Mircea; Torok, Tamas; Keller, Martin
POLICY-BASED SECURITY CHANNELS FOR PROTECTING NETWORK COMMUNICATION IN MOBILE CLOUD COMPUTING (2011)

In this paper we present a set of policy-driven security protocols for ensuring the confidentiality and integrity of enterprise data in mobile cloud computing environments. The proposed protocols leverage trusted authority entities and the “elastic” virtualized nature of the cloud computing model to provide energy-efficient key management mechanisms and policy-driven data protection techniques that support the secure interaction of the mobile client with an assortment of cloud software and storage services. The main contribution lies in: (1) Offloading the intensive asymmetric key agreement mechanisms from the mobile client and delegating them to resource-lucrative trusted authority sites. This is achieved by aggregating the security associations, required to agree on symmetric keys between the client and the cloud services, in a single security association between the client and the trusted authority. The aggregation concept results in major energy savings especially when the client consumes a relatively large set of services as is the case in cloud computing today. (2) Designing a customizable policy-based security architecture that considers the sensitivity of cloud data to provide multi-level and fine-grained data protection methodologies that suit the energy-limited mobile devices and the low-bandwidth wireless networks characterizing current mobile cloud computing models. The system is implemented in a real cloud computing environment and the savings in terms of energy consumption and execution time are analyzed.
Stem Leydig cells: From fetal to aged animals (2010)

Leydig cells are the testosterone-producing cells of the testis. The adult Leydig cell (ALC) population ultimately develops from undifferentiated mesenchymal-like stem cells present in the interstitial compartment of the neonatal testis. Distinct stages of ALC development have been identified and characterized. These include stem Leydig cells (SLCs), progenitor Leydig cells, immature Leydig cells, and ALCs. This review describes our current understanding of the SLCs in the fetal, prenatal, peripubertal, adult, and aged rat testis, as well as recent studies of the differentiation of steroidogenic cells from the stem cells of other organs.
Protein kinase A enhances, whereas glycogen synthase kinase-3β inhibits, the activity of the exon 2-encoded transactivator domain of heterogeneous nuclear ribonucleoprotein D in a hierarchical fashion (2002)

Heterogeneous nuclear ribonucleoprotein D (hnRNP D) is implicated in transcriptional regulation. Alternative splicing of exons 2 and 7 generates four isoforms of the protein. We report here that only isoforms that contain the product of exon 2 (amino acids 79-97) were able to transactivate. Moreover, the exon 2-encoded protein domain alone was sufficient to drive transcription. TATA-binding protein and p300 interacted with a synthetic peptide corresponding to exon 2, and both proteins co-precipitated with hnRNP D. Stimulation of protein kinase A (PKA) and protein kinase C (PKC) synergistically induced the transactivating ability of hnRNP D, and the exon 2-encoded domain was sufficient for this inducibility. In kinase assays PKA phosphorylated Ser-87 of hnRNP D, whereas glycogen synthase kinase-3 beta (GSK-3 beta) phosphorylated Ser-83, but only if Ser-87 had been pre-phosphorylated by PKA. Phosphorylation of Ser-87 enhanced, whereas phosphorylation of Ser-83 repressed, transactivation. Overexpression of GSK-3 beta inhibited transactivation by hnRNP D, but stimulation of PKC negated the inhibitory effect of GSK-3 beta. We suggest that a hierarchical phosphorylation pathway regulates the transactivating ability of hnRNP D: PKA activates hnRNP D, but at the same time renders it sensitive to inhibition by GSK-3 beta; the latter inhibition can be suspended by inactivating GSK-3 beta with PKC.
Face image enhancement using 3D and spectral information (2009)

This paper presents a novel method of enhancing image quality of face pictures using 3D and spectral information. Most conventional techniques directly work on the image data, shifting the skin color to a predefined skin tone, and thus do not take into account the effects of shape and lighting. The proposed method first recovers the 3D shape of a face in an input image using a 3D morphable model. Then, using color constancy and inverse rendering techniques, specularities and the true skin color, i.e., its spectral reflectance, are recovered. The quality of the input image is improved by matching the skin reflectance to a predefined reference and reducing the amount of specularities. The method realizes the enhancement in a more physically accurate manner compared to previous ones. Subjective experiments on image quality demonstrate the validity of the proposed method.
Extraordinarily large swelling energy of iodine‐treated poly(vinyl alcohol) demonstrated by jump of a film (2014)

Organic material characteristics of volume change and stress generation have attracted the attention of many researchers aiming to develop chemomechanical systems such as artificial muscles and polymer engines having the advantages of high energy density and silent operation. Although polymer gels offer a relatively large actuator stroke, their mechanical properties are relatively poor and the working temperature is relatively low, often limited by the evaporation of liquid if contained. We have developed an iodine-treated poly(vinyl alcohol) having extraordinarily large vapor-induced deswelling stress reaching 59 MPa, which is one to two orders of magnitude greater than those of ordinary polymer gels. Furthermore, this material has extremely large volumetric and gravimetric energy densities reaching 1.3 × 10<sup>6</sup> J m<sup>-3</sup> and 9.6 × 10<sup>2</sup> J kg<sup>-1</sup>, respectively, and an elastic modulus of a few GPa and is heat-resistant to at least 200 °C. The high performance of this material can be demonstrated by a jump of a film. © 2014 The Authors. Journal of Polymer Science Part B: Polymer Physics published by Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. <b>2014</b>, <i>52</i>, 1357-1365.
An Efficient Bayesian Optimization Approach for Automated Optimization of Analog Circuits (2017)

The computation-intensive circuit simulation makes the analog circuit sizing challenging for large-scale/complicated analog/RF circuits. A Bayesian optimization approach has been proposed recently for the optimization problems involving the evaluations of black-box functions with high computational cost in either objective functions or constraints. In this paper, we propose a weighted expected improvement-based Bayesian optimization approach for automated analog circuit sizing. Gaussian processes (GP) are used as the online surrogate models for circuit performances. Expected improvement is selected as the acquisition function to balance the exploration and exploitation during the optimization procedure. The expected improvement is weighted by the probability of satisfying the constraints. In this paper, we propose a complete Bayesian optimization framework for the optimization of analog circuits with constraints for the first time. The existing GP model-based optimization methods for analog circuits take the GP models as either offline models or as assistance for the evolutionary algorithms. We also extend the Bayesian optimization algorithm to handle multi-objective optimization problems. Compared with the state-of-the-art approaches listed in this paper, the proposed Bayesian optimization method achieves better optimization results with significantly less number of simulations.
A Body Size–Adjusted Maximum Ultrafiltration Rate Warning Level Is Not Equitable for Larger Patients (2021)

It is now well established that higher ultrafiltration (UF) rates during a hemodialysis session are associated with a higher propensity to intradialytic hypotension, cardiac stunning, and mortality ([1][1],[2][2]). These associations have been derived from observational dataset reports, with all of
Ketone-hybridized Cyclic Water Hexamer with Chair-conformation in Crystal of Macrocyclic peri-Aroylnaphthalene Compound (2019)

The titled macrocyclic arene ether ketone compound affords peculiarly organized crystals of dimeric molecular aggregated motif including exquisitely aligned water molecules. In the crystal, four wa...
Effects of Age, Reproductive Activity, Sex, and Prior Exposure on Sensitivity to Cucurbitacins in Southern Corn Rootworm (Coleoptera: Chrysomelidae) (1993)

Cucurbitacins, toxic to most organisms, are arrestants and phagostimulants for diabroticite chrysomelid beetles. Little is known about variation in the response of diabroticites to cucurbitacins. To quantify the effects of age, sex, reproductive status, and prior exposure to cucurbitacins on the sensitivity to cucurbitacin B of the southern corn rootworm, Diabrotica undecimpunctata howardi Barber, beetles were separated by sex and grouped for treatment with diets including or excluding cucurbitacins. Sensitivity to cucurbitacins was assayed over the first 43 d of adulthood by exposing beetles in groups of five for 24 h to filter paper strips spotted with serial methanol dilutions of cucurbitacin B ranging from 800 to 0.1 ng/ml. The areas consumed by the beetles at each dilution were then measured, and dose-response curves for each treatment were drawn. Treatments were compared in terms of the area under the mean dose response curve (AUC). Sex, age, reproductive activity, and prior exposure to cucurbitacins all significantly affected beetle sensitivity, though prior exposure was the most consistent in its effect. Exposure to cucurbitacins for as little as 6 d permanently reduced sensitivity, whereas beetles without prior exposure remained sensitive to our assay throughout the study. Reproductive activity depressed sensitivity in males but increased sensitivity in females. These results are discussed in terms of their relevance to semiochemical diabroticite baits and also to the proposed role of cucurbitacins in protecting these beetles from predators, parasites, or pathogens.
Effects of a dairy‐rich diet on blood pressure (BP): moderating effects of intracellular calcium [(Ca)i ] status (2007)

Because (Ca)i is postulated to influence BP, we assessed the hypotensive effects of a dairy-rich diet and whether the effects differed according to changes in (Ca)i. Using a randomized, 3-period, cross-over design, 23 stage 1 hypertensive adults were fed 3 experimental diets (5 wk each); high dairy, high fruits and vegetables diet (D-F&V; 30% fat, 7% saturated fat (SFA), 3.4 servings/d dairy), a low dairy, high fruits and vegetables diet (F&V; 30% fat, 7% SFA, 0.4 servings/d dairy), and an average Western diet (AWD; 36% fat, 15% SFA, 0.4 servings/d dairy). Systolic (SBP) and diastolic (DBP) blood pressure, calcitriol, and erythrocyte (Ca)i were determined. SBP and DBP were significantly reduced by ~2 mm Hg following both D-F&V and F&V diets vs. AWD (P<0.05 for each). The D-F&V diet significantly lowered calcitriol and (Ca)i vs. the two dairy-poor diets (P<0.01 for each). The reduction in (Ca)i correlated with the fall in DBP (r=0.55, P<0.03). Subjects who responded to the D-F&V diet by significantly reducing (Ca)i exhibited significantly greater drops in DBP on the D-F&V (−14 ± 3.4 mm Hg) vs. the F&V (−10 ± 3.4 mm Hg) and AWD diets (−8 ± 3.4 mm Hg; diet x group interaction, P<0.02). The results suggest that (Ca)i is responsive to diet and that a dairy-rich diet produces an ideal intracellular environment, which may result in improved BP. Funding: Dairy Management Inc., GCRC of Penn State University NIH M01 RR10732
Preparation of pH-Responsive Mesoporous Silica Nanoparticles and Their Application in Controlled Drug Delivery (2011)

Poly(acrylic acid) grafted mesoporous silica nanoparticles (PAA-MSNs) were prepared by a facile graft-onto strategy, i.e., the amidation between PAA homopolymer and amino group functionalized MSNs. The resultant PAA-MSNs were uniform spherical nanoparticles with a mean diameter of approximately 150 nm, and the graft amount of PAA evaluated by thermogravimetric analysis (TGA) was about 12 wt %. Due to the covalent graft of hydrophilic and pH-responsive PAA, the PAA-MSNs could be well dispersed in aqueous solution, which is favorable to be utilized as drug carriers to construct a pH-responsive controlled drug delivery system. N2 adsorption–desorption isotherm results demonstrated that doxorubicin hydrochloride (DOX), a well-known anticancer drug, could be effectively loaded into the channels of PAA-MSNs through the electrostatic interaction. The loading content and the entrapment efficiency of DOX could reach up to 48% and 95%, respectively. The drug release rate of DOX@PAA-MSN was pH dependent and increased with the decrease of pH. The in vitro cytotoxicity test indicated that PAA-MSNs were highly biocompatible and suitable to use as drug carriers. The drug-loaded DOX@PAA-MSNs were distinctly cytotoxic to HeLa cells, due to the sustained release of drug, and showed higher clinical effects than free DOX. These results imply that the PAA-MSNs are promising platforms to construct pH-responsive controlled drug delivery systems for cancer therapy.