gebhart/patrepeval huggingface dataset:
Analysis of synthetic peptides from heptad-repeat domains of herpes simplex virus type 1 glycoproteins H and B (2006)

Human herpesviruses enter cells by fusion of their own membrane with a cellular membrane through the concerted action of multiple viral proteins and cellular receptors. Two conserved viral glycoproteins, gB and gH, are required for herpes simplex virus type 1 (HSV-1)-mediated membrane fusion, but little is known of how these proteins cooperate during entry. Both glycoproteins were shown to contain heptad repeat (HR) sequences predicted to form alpha-helical coiled coils, and the inhibitory activity against infection of four sets of synthetic peptides corresponding to HR1 and HR2 of gB and gH was tested. The interactions between these HR peptides were also investigated by circular dichroism, native polyacrylamide-gel electrophoresis and size exclusion high-performance liquid chromatography. gH coiled-coil peptides were more effective than gB coiled-coils peptides in inhibiting virus infectivity. The peptides did not impair fusion when added to cells immediately after infection. In contrast, inhibition of infection was observed, albeit to various extents, when peptides were added to virus before or during inoculation. The results of biophysical analyses were indicative of the existence of an interaction between HR1 and HR2 of gH and suggest that the HRs of gB and gH do not interact with each other.
Relationship between myopia and allergen‐specific serum IgE levels in patients with allergic conjunctivitis (2009)

These results suggest that specific IgE levels for indoor allergens, such as house dust, might be associated with refractive errors.
Event Occurrence Date Estimation based on Multivariate Time Series Analysis over Temporal Document Collections (2021)

Real world events are quite often mentioned in texts. Estimating the occurrence time of event mentions has many applications in IR, QA, general document understanding and downstream NLP tasks. In this paper we propose an approach to temporal profiling of event mentions in text. Our method utilizes a news article archival collection for collecting temporal as well as textual information containing contemporary and retrospective event references. As we demonstrate in our experiments, the recent method which relies on secondary data sources like Wikipedia is insufficient to correctly estimate the event time, especially, for minor or less well-known events that happened in the past. Our method then harnesses news article archives to effectively infer the occurrence time of past events, and is able to estimate the time at different temporal granularities (e.g., day, week, month, or year). As evidenced through extensive experiments, the proposed model outperforms the existing methods by a large margin at all granularities. We also demonstrate that our approach helps to answer arbitrary questions about past events, when incorporated into a QA framework operating over news article archives.
MULTIPLE-DOSE SAFETY TOLERANCE OF L-693,487 (Heptylphysostigmine) IN ALZHEIMERʼS DISEASE (AD). (1992)

Cutler, N. R. M.D.; Sramek, J. J. Pharm.D.; Block, G. M.D. Ph.D.; McLean, L. Ph.D.; Reines, S. M.D. Ph.D.; Sawin, S. R.N.; Barchowsky, A. Ph.D. Author Information
Monolithic integration of InGaAs p-i-n photodetector with full ion-implanted InP JFET amplifier (1988)

A monolithically integrated p-i-n FET amplifier, fabricated using ion-planted indium-phosphide (InP) JFETs, is described. The vertically integrated structure consists of a vapor-phase epitaxy (VPE)-grown InGaAs photoabsorption layer and a metal-organic-chemical-vapor-disposition (MOCVD)-grown Fe-doped semi-insulating layer. A Zn diffusion was performed to complete the p-i-n photodiode. High-performance fully implanted InP JFETS were used to form the integrated amplifier with a symmetrical design to remove the DC offset. With a receiver sensitivity of -36.4 dBm measured at 200 Mb/s NRZ for 10/sup -9/ BER, it is thought to be the most sensitive monolithic p-i-n FET preamp yet reported in this frequency range. The p-i-n amplifier has a dynamic range of 15 dB.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Optical Imaging with Her2-Targeted Affibody Molecules Can Monitor Hsp90 Treatment Response in a Breast Cancer Xenograft Mouse Model (2012)

Optical imaging with an affibody can be used to noninvasively monitor changes in Her2 expression in vivo as a response to treatment with an Hsp90 inhibitor, with results similar to response measurements in positron emission tomography imaging studies.
Experimental characterization of Enhancement ModeGaN power FETs at cryogenic temperatures (2016)

High power density converters in combination with cryogenic power systems could have a significant effect on the electrification of transportation systems as well as other energy conversion systems ...
Crack Management System Using the Embedded Device for Drone Mounting (2022)

Bridge damage is a case in which physical forces act on the inside and outside of the bridge and maintain it in an unstable state, such as cracks, breakage, deformation, and erosion. As concrete is a brittle material, it is easily broken by external impact and can lead to serious accidents due to loss of function, so periodic management is essential. In this paper, we propose a crack management system using the embedded device for drone mounting. The embedded device for drone mounting is connected to a distance sensor, GPS module, and a camera to photograph the bridge in real time and uses a machine learning algorithm to find cracks in the bridge. When the embedded device finds a crack with a camera, it sends JSON formatted crack detection data including GPS position, timestamp, base64 encoded image data, and additional information to the crack management server over MQTT. We also propose a crack management algorithm and implemented a crack management server using a proposed algorithm. A proposed crack management server is implemented by the python web framework flask and a tensorflow machine learning library, and saves data with a mariaDB database server. The proposed system can enable fast and efficient management by using a real-time analysis method rather than a method of analyzing filmed video.
Modulation of immune responses to hepatitis C virus envelope E2 protein following injection of plasmid DNA using single or combined delivery routes (1998)

Different delivery routes of plasmid DNA may result in the induction of differential humoral and cellular immunity. We have studied the influence of two main routes of plasmid injection, performed intramuscularly and intraepidermally using a gene gun, for the induction of immune responses specific to hepatitis C virus (HCV) envelope protein E2. Three plasmids expressing different immunogenic domains of E2 (amino acids [aa] 384443, aa 504-555, and aa 384-746) were injected into BALB/c mice according to five different protocols using various combinations of intramuscular (i.m.) or intraepidermal (i.e.) primary and booster injections. Seroconversion rates, antibody titers and isotypes, epitope recognition, and T-helper (Th) release cytokine profiles were analyzed. Antibody titers and epitope recognition were linked to either or both the nature of the immunogen expressed and the delivery route chosen. In all cases, the lowest antibody titers were obtained using single i.m.-based protocols. Independently of the antibody titers generated, only some specific i.e.-combined delivery routes induced antibodies able to recognize determinants located in the N-terminal of E2 (aa 384411 and aa 411437) and mimicked by synthetic peptides. By contrast, the antibody isotypes and the splenic cytokine production identified were independent of the plasmids used and the delivery route implemented. All conditions resulted in Th-1 like responses suggested by the exclusive detection of IgG2a and 2b antibodies and the production of interferon gamma (INF-gamma) but no interleukin-4 (IL-4). Overall, our results suggest that the combination of i.m. and i.e. delivery routes provides the most efficient way to induce a broad immune response against HCV-E2.
Supply-Chain Vulnerability Elimination via Active Learning and Regeneration (2021)

Software supply-chain attacks target components that are integrated into client applications. Such attacks often target widely-used components, with the attack taking place via operations (for example, file system or network accesses) that do not affect those aspects of component behavior that the client observes. We propose new active library learning and regeneration (ALR) techniques for inferring and regenerating the client-observable behavior of software components. Using increasingly sophisticated rounds of exploration, ALR generates inputs, provides these inputs to the component, and observes the resulting outputs to infer a model of the component's behavior as a program in a domain-specific language. We present Harp, an ALR system for string processing components. We apply Harp to successfully infer and regenerate string-processing components written in JavaScript and C/C++. Our results indicate that, in the majority of cases, Harp completes the regeneration in less than a minute, remains fully compatible with the original library, and delivers performance indistinguishable from the original library. We also demonstrate that Harp can eliminate vulnerabilities associated with libraries targeted in several highly visible security incidents, specifically event-stream, left-pad, and string-compare.
Heterocycles (1970)

RETURN TO ISSUEPREVNewsNEXTHeterocyclesHigh growth potential awaits exploitation by modern methodsALAN R. KATRITZKYView Author Information University of East Anglia, EnglandCite this: Chem. Eng. News 1970, 48, 16, 80–89Publication Date (Print):April 13, 1970Publication History Published online7 November 2010Published inissue 13 April 1970https://pubs.acs.org/doi/10.1021/cen-v048n016.p080https://doi.org/10.1021/cen-v048n016.p080newsACS PublicationsCopyright © 1970 AMERICAN CHEMICAL SOCIETYArticle Views8Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options SUBJECTS:Approximation,Heterocyclic compounds,Ions,Nitrogen,Pharmaceuticals Get e-Alerts
Anisotropic small-angle neutron scattering studies of ceramics (1999)

This paper discusses how small-angle neutron scattering studies can be applied in two variations to obtain a representative characterization of the large, densely-populated, and anisotropic features that occur in the microstructures of various materials. The use of Pored scattering to amplify the anisotropies that are present, permitting different microstructural components to be identified, is discussed. Measurement of the anisotropic beam-broadening due to multiple small-angle neutron scattering is also described, as is its use to extract mean sizes and volume-fractions for the component microstructures. The work is illustrated by a small-angle scattering study of microcracking in a strongly textured anisotropic ceramic.
A method of evaluating the transfer capacity for power system considering of the power injection and the power grid topology (2015)

The transfer capacity is a varying value for a certain power system, which may be changed with the evolution of the system. Although the topology of a power system is usually designed in an optimizing way to maximize the transfer capability, the capability itself will be inevitably weaken because of a time lag between the increasing load and the enhancement of grid topology. Due to the lack of qualification tools to deal with the varying transfer capability, related topics are seldom to be discussed. This paper proposes a new method to evaluate the transfer capacity, in which the mechanism describing the mismatch can be boiled down to a new index named Spatial Characteristic Length Ratio (SCLR) considering of both the power injection and the power grid topology. By calculating the index SCLR, the transfer capability as well as the factors affecting it can be analyzed, which has an important meaning for power grid planning personnel. The method is used to analyze the transfer capacity of IEEE 4-node system, IEEE 9-node system and IEEE 162-node system, each under different modes of operation. Calculation results has proved the validity of this concept, and the related method is effective.
Real-time tracking and estimation of plane pose (2003)

In this paper we present a method to estimate in real-time the position and orientation of a previously viewed planar patch. The algorithm is based on minimising the sum of squared differences between a previously stored image of the patch and the current image of it. First a linear model for projectively tracking a planar patch is introduced, then a method to compute the 3D position and orientation of the patch in 3D space is presented. In the experiments conducted we show that this method is adequate for tracking not only planar objects, but also non planar objects with limited out-of-plane rotations, as is the case of face tracking.
Peptidyl fluoromethyl ketones as thiol protease inhibitors. (1986)

The fluoromethyl ketone derivatives of peptides are now available through several synthetic approaches and can be examined with respect to their properties as protease inhibitors. It had been expected that the fluoro atom might be too inert for nucleophilic displacement and that irreversible inactivation might not be achievable by this type of derivative in contrast to chloromethyl ketones. However, with serine and cysteinyl proteases, alkylation of the enzyme does take place although the rates are not similar to those of the chloromethyl ketones. Of the two classes, thiol proteases are more readily inactivated and the fluoromethyl ketones are almost as effective as the chloromethyl ketones. Our observations confirm and extend those of Rasnick (Anal. Biochem. 149, 461-465 (1985)). The structure of the peptidyl portion of the reagent controls specificity of inhibition in the typical manner of affinity-labels for proteases. However, fluoromethyl ketones are considerably less reactive to nucleophiles such as the thiol group of glutathione, than chloromethyl ketones and, therefore, this new class of inhibitors may provoke fewer side reactions when used in biological studies.
Evaluation of dental students’ responses to roleplay videos in a professionalism course (2020)

In our study, the impact of roleplay videos was recognised by a majority of the students. Female students and those with high grades highly rated learning through this method of teaching. Video assignments should be a part of professionalism courses in dentistry to improve students' communication skills and professional behaviours with colleagues and patients.
A Hollow Rectangular Coaxial Line for Slot Array Applications Fabricated by Diffusion Bonding of Laminated Thin Metal Plates (2013)

A hollow rectangular coaxial line is designed for the 60-GHz band and fabricated by diffusion bonding of laminated thin metal plates. A low transmission loss of 0.036 dB/cm is confirmed at 60 GHz by measurement in a designed rectangular coaxial line. The suspended inner conductor is supported by a thin plate. A longitudinal slot excited by the metal support and its linear array are presented. The proposed structures are verified by comparing the measured results with the designed ones. The 1.5% bandwidth of the linear array for reflection below -14 dB is obtained by the measurement.
Development of a ferrocene-mediated needle-type glucose sensor covered with newly designed biocompatible membrane, 2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate. (1995)

To prepare the long-life and stable glucose sensor, we developed the ferrocene-mediated needle-type glucose sensor covered with newly designed biocompatible membrane, 2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate (MPC-co-BMA) membrane. In this membrane, the hydrophilic phosphorylcholine chains were grafted on the hydrophobic polymer surface. 1. The poly(MPC-co-BMA) membrane inhibited platelet activation and protein adhesion on the surface, showing excellent biocompatibility. These results suggested that the hydrophilic phospholipids chains might have the potential for suppressing activation and adsorption of biochemical molecules. 2. The ferrocene-mediated needle-type glucose sensor covered with poly(MPC-co-BMA) membrane achieved excellent results in vitro. Subcutaneous tissue glucose concentrations were measured in a wide range from 1.7 to more than 16.7 mmol/l. The correlation between subcutaneous tissue (Y) and blood (X) glucose concentrations was Y = 1.04X + 0.12 (r = 0.98). The subcutaneous tissue glucose concentrations could be monitored precisely for 7 days without any in vivo calibrations, and for 14 days by introducing in vivo calibrations. We therefore conclude that this sensor is stable and reliable, as compared to any other glucose sensors we developed.
A study of microstrip coupler with high directivity (2002)

A small-size microstrip coupler with interdigital compensation capacitors for high directivity is introduced, and the optimization design method of HP EESOF software is introduced. A design parameter table of coupling (15-25 dB) is provided, and the calculation method of the interdigital capacitors is given. The given examples show that this type of method is feasible and accurate.
Design, synthesis, and applications of ring‐functionalized histidines in peptide‐based medicinal chemistry and drug discovery (2023)

Modified and synthetic α-amino acids are known to show diverse applications. Histidine, which possesses numerous applications when subjected to synthetic modifications, is one such amino acid. The utility of modified histidines varies widely from remarkable biological activities to catalysis, and from nanotechnology to polymer chemistry. This renders histidine residue an important place in scientific research. Histidine is a well-studied scaffold and constitutes the active site of various enzymes catalyzing important reactions in the biological systems. A rational modification in histidine structure with a distinctly developed protocol extensively changes its physical and chemical properties. The utilization of modified histidines in search of potent, target selective and proteostable scaffolds is vital in the development of bioactive peptides with enhanced drug-likeliness. This review is a compilation and analysis of reported side-chain ring modifications at histidine followed by applications of ring-modified histidines in the synthesis of various categories of bioactive peptides and peptidomimetics.
The “complex” RNA post-transcriptional element of a “simple” retrovirus (2015)

Replication of retroviruses and transposition of endogenous retroelements exploits a unique mechanism of post-transcriptional regulation as a means of exporting their incompletely-spliced mRNAs (which serve as both the genomic RNA and the template for protein synthesis). Following discovery of the Rev response element (RRE) that mediates nucleocytoplasmic export of the full-length and singly-spliced human immunodeficiency virus type 1 (HIV-1) genome, equivalent <i>cis</i>-acting regulatory elements have been characterized for both complex and simple retroviruses and retroelements, together with the obligate viral and host proteins with which they interact. The exception to this is the gammaretrovirus family of simple retroviruses, exemplified by reticuloendotheliosis virus (REV), murine leukemia virus (MLV) and xenotropic MLV-related retrovirus (XMRV). In this commentary, we discuss our recent data that reported structural and functional data on the MLV/XMRV post-transcriptional regulatory element (designated the PTE). The PTE was characterized by a highly-structured region of multiple stem-loops (SL1 - SL7) overlapping the <i>pro</i> and 5' portion of the <i>pol</i> open reading frames, comprising a bipartite export signal whose structures are separated by ∼1400 nt. In addition, structural probing suggested that SL3 nucleotides were involved in pseudoknot formation. These data, when compared with RNA transport elements of complex retroviruses (HIV) and simple murine retrotransposons (<i>musD</i>), collectively present an emerging picture that long-range tertiary interactions are critical mediators of their biological function.
Heparin–cellulose–charcoal composites for drug detoxification prepared using room temperature ionic liquids (2008)

We report novel heparin-cellulose-charcoal composites prepared using room temperature ionic liquids (RTILs) to enhance the biocompatibility and blood compatibility of activated charcoal beads while decreasing the size of their active pores.
[Lipid levels and lipid peroxidation in frog tissues during hyperthermia and hibernation]. (1990)

The content of cholesterol, phospholipids, free fatty acids in the blood, ketone bodies and lipid peroxidation in the liver, brain, myocardium, skeletal muscles of Rana ridibunda were studied. Changes in the lipid content in blood during artificial hypothermia differ from those during hibernation and arousal. The utilization of reserve fats during hibernation is limited, but significantly rises during arousal. The ability to spontaneous lipid peroxidation under conditions of homogenate incubation at 37 degrees C does not increase in the studied tissues during hibernation.
Restrictive blinding of secret-key certificates (1995)

Many signature transporting mechanisms require a signer to issue triples, consisting of a secret key, a matching public key, and a certificate of the signer on the public key. Of particular interest are so-called restrictive blind signature issuing protocols, in which the receiver can blind the issued public key and the certificate but not a certain predicate of the secret key. This paper describes the first generally applicable technique for designing efficient such issuing protocols, based on the recently introduced notion of secret-key certificates. The resulting three-move issuing protocols require the receiver to perform merely a single on-line multiplication, and the property of restrictive blinding can be proved with respect to a plausible intractability assumption. Application of the new issuing protocols results in the most efficient and versatile off-line electronic cash systems known to date, without using the blind signature technique developed by Chaum.