gebhart/patrepeval huggingface dataset:
Factor V Leiden in pregnancies complicated by placental abruption (2003)

Objective Recent studies suggest an increased prevalence of obstetric complications in female carriers of hereditary or acquired thrombophilias. The aim of the study was to determine if carriership of the factor V (FV) Leiden mutation (activated protein C [APC] resistance) is higher in women who have had of placental abruption during pregnancy. Design A retrospective case–control study. Setting University Hospital MAS, Malmö, Sweden. Methods A comparison of 102 women with placental abruption with 2371 prospectively collected controls. Carriership of FV Leiden was determined and the women were interviewed. Main outcome measures Proportion of FV Leiden carriership, first degree heritage of thrombosis and previous placental abruption in cases and controls. Results Carriage of FV Leiden was found in 15.7% of women who have had placental abruption as compared with 10.8% of controls ( P = 0.12, odds ratio [OR] = 1.5, 95% confidence interval [CI] = 0.9–2.7 ). Around 20% of women with placental abruption reported first degree heritage for venous thrombosis, as compared with 6.7% of controls ( P ≤ 0.001 ). Conclusions FV Leiden carriership was not significantly different in women with placental abruption. However, there was an increased prevalence of first degree heritage for venous thrombosis in women with placental abruption, indicating a higher prevalence of thrombophilia among women with placental abruption.
Effects of nicotine on oviducal blood flow and embryo development in the rat (1985)

Nicotine (5.0 mg/kg) was injected (s.c.) twice daily on Day 1 or Days 1-4 or 1-5 of pregnancy. Cumulative doses of nicotine retarded embryo cell cleavage and substantially reduced embryo cell number (saline vs nicotine: 42.5 +/- 1.7 vs 22.1 +/- 1.9 nuclei/embryo, at 12:00 h on Day 5; P less than 0.05). However, treatment for even 1 day (Day 1) significantly reduced cell number (saline vs nicotine: 42.5 +/- 1.7 vs 30.5 +/- 0.9, at 12:00 h day on Day 5; P less than 0.01). Nicotine injection also resulted in a marked and prolonged reduction in oviduct blood flow (pretreatment vs 90 min after nicotine: 0.61 +/- 0.06 vs 0.37 +/- 0.10 ml/min . g-1; P less than 0.005). The results indicate that, in the rat, even a brief exposure to nicotine, the chief alkaloid of tobacco, reduces oviducal blood flow and the rate of embryo cell proliferation. The embryo is therefore susceptible to the effects of nicotine before implantation.
Entanglements in binary and ternary blends of narrow molecular weight distribution polystyrenes (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEntanglements in binary and ternary blends of narrow molecular weight distribution polystyrenesHiroshi Watanabe and Tadao KotakaCite this: Macromolecules 1987, 20, 3, 535–543Publication Date (Print):March 1, 1987Publication History Published online1 May 2002Published inissue 1 March 1987https://pubs.acs.org/doi/10.1021/ma00169a012https://doi.org/10.1021/ma00169a012research-articleACS PublicationsRequest reuse permissionsArticle Views69Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Vaccination status and needs of asylum-seeking children in Denmark: a retrospective data analysis (2018)

The finding that nearly one-third of asylum-seeking children and adolescents in Denmark were in need of further vaccinations highlights the gaps in immunisation coverage in these populations. These results point to the need to improve access to health services and promote national vaccine programmes targeted at these communities to facilitate vaccination uptake and increase immunisation coverage to reduce the risk of preventable infectious diseases among asylum-seeking children.
Benchmarking of current generation overlay systems at the 130-nm technology node (2003)

The Overlay Metrology Advisory Group (OMAG) is a group comprised of technical experts in the field of optical metrology from International SEMATECH Member Companies and the National Institute of Standards and Technology (NIST). This council created a specification for overlay metrology benchmarking which indicates the critical parameters to be addressed in order to comply with the International Technology Roadmap for Semiconductors (ITRS) for the 130-nm technology node. A benchmarking study was completed that compares several of the currently available overlay metrology tools. This paper contains the methodologies for benchmarking overlay metrology tools, a comparison of repeatability, reproducibility, throughput, tool-induced shift (TIS) variability, accuracy, and TIS through focus measurements between the participating tools. The tools were identified to the International SEMATECH Member Companies and the appropriate tool suppliers. The identity of the tools will remain only with these select groups. This paper intends to serve as a reference to the current tools' ability to meet the ITRS Roadmap specifications for the 130-nm technology node.
Molecular dynamics simulations reveal ligand-controlled positioning of a peripheral protein complex in membranes (2017)

Bryostatin is in clinical trials for Alzheimer's disease, cancer, and HIV/AIDS eradication. It binds to protein kinase C competitively with diacylglycerol, the endogenous protein kinase C regulator, and plant-derived phorbol esters, but each ligand induces different activities. Determination of the structural origin for these differing activities by X-ray analysis has not succeeded due to difficulties in co-crystallizing protein kinase C with relevant ligands. More importantly, static, crystal-lattice bound complexes do not address the influence of the membrane on the structure and dynamics of membrane-associated proteins. To address this general problem, we performed long-timescale (400-500 µs aggregate) all-atom molecular dynamics simulations of protein kinase C-ligand-membrane complexes and observed that different protein kinase C activators differentially position the complex in the membrane due in part to their differing interactions with waters at the membrane inner leaf. These new findings enable new strategies for the design of simpler, more effective protein kinase C analogs and could also prove relevant to other peripheral protein complexes.Natural supplies of bryostatin, a compound in clinical trials for Alzheimer's disease, cancer, and HIV, are scarce. Here, the authors perform molecular dynamics simulations to understand how bryostatin interacts with membrane-bound protein kinase C, offering insights for the design of bryostatin analogs.
Data from PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;Through an shRNA screen, we identified the protein arginine methyltransferase Prmt1 as a vulnerable intervention point in murine p53/Rb-null osteosarcomas, the human counterpart of which lacks effective therapeutic options. Depletion of Prmt1 in p53-deficient cells impaired tumor initiation and maintenance &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt;. Mechanistic studies reveal that translation-associated pathways were enriched for Prmt1 downstream targets, implicating Prmt1 in translation control. In particular, loss of Prmt1 led to a decrease in arginine methylation of the translation initiation complex, thereby disrupting its assembly and inhibiting translation. p53/Rb-null cells were sensitive to p53-induced translation stress, and analysis of human cancer cell line data from Project Achilles further revealed that Prmt1 and translation-associated pathways converged on the same functional networks. We propose that targeted therapy against Prmt1 and its associated translation-related pathways offer a mechanistic rationale for treatment of osteosarcomas and other cancers that exhibit dependencies on translation stress response. &lt;i&gt;Cancer Res; 77(17); 4613–25. ©2017 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Supplementary Table 2 from A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer (2023)

&lt;p&gt;PDF file - 62K, unsupervised top 10 positive and negative correlated genes - clinical.&lt;/p&gt;
DNA binding and transactivation activity of A-myb, a c-myb-related gene. (1994)

A partial-length A-myb complementary DNA recently cloned by low-stringency hybridization with a c-myb probe to complementary DNA libraries derived from human cell lines showed a high degree of homology with the DNA-binding domain of c-myb and B-myb, suggesting that A-myb also encoded a DNA-binding protein. We report here the sequence of the entire coding region of A-myb complementary DNA and show that the full-length GST-A-myb fusion protein or a truncated derivative corresponding only to the putative DNA-binding domain interacts specifically with Myb-binding sites of the c-myb responsive promoters, MIM-1 and CD34. In transient transfection assays, A-myb transactivated the bound promoters. These results suggest that, analogous to the other members of the Myb family, the A-myb gene encodes a bona fide transactivator. The distinct function of A-myb might derive from its pattern of expression and/or its relative potency as a transactivator of myb target genes.
Rational design, synthesis and biological evaluation of the first inhibitor of lignin polymerization (1997)

A fluorinated analogue of coniferin (the glucoside of coniferyl alcohol) has been synthesized in three steps from vanillin tetraacetyl glucoside; bearing a fluorine atom on the β position of the propenyl side chain which is involved in the main site of coupling, it is designed as a potential inhibitor of oxidases involved in the biosynthesis of lignin, and in vivo experiments show a pronounced inhibition of lignin biosynthesis in poplar plantlets, with a five-fold decrease in lignin formed.
Synthesis of Magnetic Molecularly Imprinted Poly(ethylene-co-vinyl alcohol) Nanoparticles and Their Uses in the Extraction and Sensing of Target Molecules in Urine (2010)

Superparamagnetic nanoparticles are of great current interest for biomedical applications in both diagnostics and treatment. Magnetic nanoparticles (MNP) can be manipulated by magnetic fields, so that when functionalized, they can be used for the purification and separation of biomolecules and even whole cells. Here we report combining the separation capabilities of MNPs with the functional (binding) capability of molecularly imprinted polymers. Albumin- creatinine-, lysozyme-, and urea-imprinted polymer nanoparticles were synthesized from poly(ethylene-co-ethylene alcohol) via phase inversion, with both target molecules and hydrophobic magnetic nanoparticles mixed within the polymer solution. Several ethylene:ethylene alcohol mole ratios were studied. The rebinding capacities for those three target molecules varied from 0.76 ± 0.02 to 5.97 ± 0.04 mg/g of molecularly imprinted magnetic nanoparticles. Lastly, the composite nanoparticles were used for separation and sensing of template molecules (e.g., human serum albumin) in real samples (urine) and results were compared with a commercial ARCHITECT ci 8200 system.
Technology for LPP Sources (2010)

The availability of EUV light sources, measurement tools, and integrated test systems is of major importance for the development of EUVL to be used in high-volume chip manufacturing, which is expected to start in 2009. For economic use of EUVL, a throughput of 100 wafers per hour will be necessary, as estimated from the cost of an EUV exposure tool in combination with sophisticated throughput models. This means that light sources will be necessary that deliver an EUV output power of 115 W at 13.5 nm at the entrance of the illuminator system. The choice of the wavelength is derived from a general convention to use Mo∕Si-based reflection coatings on the near-normal-incidence mirrors of the lithography system. The power specification in combination with the required lifetimes of source components and collector optics makes the source technology the most critical issue in developing EUVL. LPPs as sources for EUV radiation are a promising technical approach because of their physical principle, which allows one to manage the thermal load of source components to provide sufficient component lifetimes. As a result, the EUV output power seems to be scalable to high-volume manufacturing (HVM) requirements. At XTREME technologies GmbH—a joint venture of Lambda Physik AG, Göttingen, and Jenoptik LOS GmbH, Jena, Germany—EUV sources based on the generation of a plasma by an electrical gas discharge and by laser excitation have been investigated and developed since 2001. This chapter gives an overview of the basics of LPP EUV sources and their technology, the development roadmap, and the current state of the art of these light sources at XTREME technologies. An overview of GDPP EUV sources at XTREME technologies is contained in Chapter 14.
Glucose transport inAcanthocheilonema viteae (1990)

The uptake of glucose by Acanthocheilonema viteae was studied in vitro. The process was selective for the D-isomer and saturatable with a Km of 2 mM. The rate of glucose transport/utilization was inhibited by 2-deoxyglucose, mannose, 5-thioglucose and dipyridamole but, unlike mammalian systems, was not impaired by cytochalasin B, phloretin, phloridzin, 3-O-methylglucose and 4,6-ethylideneglucose. A potential chemotherapeutic advantage of selectively inhibiting filarial glucose transport exists for the following reasons. (1) The glucose transporter present in A. viteae was shown to be different from the one present in some mammalian systems. (2) Incubation under glucose-free conditions led to glycogen depletion, loss of motility and worm death. (3) Worms maintained in vitro for more than 18 h without glucose did not survive when implanted into gerbils.
ChemInform Abstract: Indan‐1,3‐diones. Part 9. Synthesis and Antiinflammatory Activity of 2‐ Polyaza‐arylindan‐1,3‐diones and Their N‐ or O‐Substituted Derivatives. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Susceptibility of Cultivars and Hybrids of Kousa Dogwood to Dogwood Anthracnose and Powdery Mildew (1995)

Twenty taxa of dogwood including cultivars of kousa dogwood (Cornus kousa) and cultivars of hybrids between flowering (Cornus florida) and kousa dogwoods were evaluated for susceptibility to dogwood anthracnose (Discula destructiva) and powdery mildew (Microsphaerapulchra). Trees were grown under the canopy of a native stand of flowering dogwood that was infected with both diseases and were also inoculated artificially with spores of D. destructiva. None of the taxa were found to be immune to dogwood anthracnose, yet there was considerable variation in resistance to the disease. Cornus kousa 'Steeple', a clone of C. kousa 'Milky Way', C. x Stardust®, C. x Stellar Pink®, and C. x Celestial™ were found to be resistant to dogwood anthracnose as indicated by &lt; 1 % of total leaf area affected, 100% survival through the following spring, and no detection of D. destructiva in woody tissue. The C. kousa cultivars 'Wolf Eyes', 'Moonbeam', and 'Autumn Rose' and seedlings of C. florida were highly susceptible with 100% of the total leaf area affected and 100% mortality by the following spring. The other taxa were intermediate in susceptibility to D. destructiva. Only five of the taxa: C. kousa 'Elizabeth Lustgarten' and 'Steeple' and the hybrids C. x Stardust®, C. x Constellation®, and C. x Ruth Ellen® were infected by M. pulchra.
Study of Radio Channel for Biomedical Sensors in Spacesuits (2013)

Current space suits use conventional wired links to acquire bio-medical sensor data. Replacing these with wireless links would provide a number of operational benefits, but the radio path loss environment must be understood first. In this paper, we study the radio channel of body area networks for s
2차원 침수해석을 위한 수리학적 건물 일반화 기법의 적용 (2015)

인류의 문명의 시작된 이래 도시유역의 침수는 거주민과 해당지역의 시설에 화학적이고 물리적인 피해를 입혀왔다. 최근의 연구는 도시홍수와 침수를 해석을 위한 모델과 지형자료의 통합에 관한 연구가 주를 이뤄왔다. 그러나 2차원 모델의 구축과정에 많은 시간이 소요되고 높은 데이터 처리기술을 요구하는 경향이 있다. 게다가 건물의 격자화 과정에서 의도치 않는 격자가 발생하게 되어 해석결과의 신뢰도를 떨어뜨리기 때문에 고해상도의 데이터 구득과 모형을 구축하더라도 건물의 처리기법에 따라 해석결과가 달라진다. 따라서 2차원 침수해석모형의 건물의 자료를 입력 시에는 이러한 왜곡현상을 최소화 할 수 있도록 건물의 일반화 처리 혹은 건물의 직교성 확보 등의 전처리가 필요하다. 이에 본 연구의 목적은 2차원 침수해석결과의 신뢰도를 향상시킬 수 있는 건물의 일반화 기법을 개발하고 건물의 일반화에 따른 영향을 검토하는데 있다. 연구결과, 도시지역의 2차원 침수해석결과의 신뢰도를 향상시키기 위해서는 각종 수치지도로부터 DBM(Digital BuildingModel)을 생성하고 본 연구에서 제안한 방법 Aggregation-Simplification을 적용하여 건물의 일반화를 수행하는 것이 바람직하며 각 기법의 임계값은 대상지역의 건물의 공간적인 특성을 고려하여 설정하되 건물의 평균 간격과 건물 간격의 표준편차를 더한 값을 초과하지 않는 것이 바람직한것으로 나타났다.
Fourth‐line rescue therapy with rifabutin in patients with three Helicobacter pylori eradication failures (2012)

Even after three previous H. pylori eradication failures, an empirical fourth-line rescue treatment with rifabutin may be effective in approximately 50% of the cases. Therefore, rifabutin-based rescue therapy constitutes a valid strategy after multiple previous eradication failures with key antibiotics, such as clarithromycin, metronidazole, tetracycline and levofloxacin.
Development and Characterization of a 10x Schwarzschild System for Soft-X-Ray Projection Lithography (1993)

Multilayer-coated Schwarzschild imaging objectives have been used to demonstrate high-resolution soft-x-ray imaging. 1-2 In our previous work 3 a 20x reduction Schwarzschild imaging objective served a useful tool for studying the mounting and alignment of soft-xray optical elements and the quality and alignment of the condensing optics. However, the field of view, 25 μm by 50 μm, is much too small for a practical lithography tool. We have optimized and fabricated a new Schwarzschild system to achieve a 0.4 mm diameter field of view using 0.1 μm design rules. The increased field of view, although not large enough for a practical lithography tool, approximates the ring width in practical ring-field designs. This objective also covers enough area on the wafer to perform device fabrication experiments. This paper describes the development and characterization of the imaging system and the supporting illumination system.
Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth (2011)

Endoglin (CD105), a transmembrane protein of the transforming growth factor β superfamily, plays a crucial role in angiogenesis. Mutations in endoglin result in the vascular defect known as hereditary hemorrhagic telangiectasia (HHT1). The soluble form of endoglin was suggested to contribute to the pathogenesis of preeclampsia. To obtain further insight into its function, we cloned, expressed, purified, and characterized the extracellular domain (ECD) of mouse and human endoglin fused to an immunoglobulin Fc domain. We found that mouse and human endoglin ECD-Fc bound directly, specifically, and with high affinity to bone morphogenetic proteins 9 and 10 (BMP9 and BMP10) in surface plasmon resonance (Biacore) and cell-based assays. We performed a function mapping analysis of the different domains of endoglin by examining their contributions to the selectivity and biological activity of the protein. The BMP9/BMP10 binding site was localized to the orphan domain of human endoglin composed of the amino acid sequence 26-359. We established that endoglin and type II receptors bind to overlapping sites on BMP9. In the in vivo chick chorioallantoic membrane assay, the mouse and the truncated human endoglin ECD-Fc both significantly reduced VEGF-induced vessel formation. Finally, murine endoglin ECD-Fc acted as an anti-angiogenic factor that decreased blood vessel sprouting in VEGF/FGF-induced angiogenesis in in vivo angioreactors and reduced the tumor burden in the colon-26 mouse tumor model. Together our findings indicate an important role of soluble endoglin ECD in the regulation of angiogenesis and highlight efficacy of endoglin-Fc as a potential anti-angiogenesis therapeutic agent.
Dual mode efficiency enhanced linear power amplifiers using a new balanced structure (2009)

This paper presents a new balanced architecture to improve the power added efficiency (PAE) of a 3G handset power amplifier without trading-off its stringent linearity requirement. It is modified from the structure of our Switched Load Insensitive Power Amplifier (LIPA®). Power amplifiers using this modified balanced structure retain the main features of the LIPA and provide boosted PAE performance in low and high power mode. The novel balanced structure is implemented into 4×4mm <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> power amplifier modules at both CELL and UMTS bands. For the UMTS band at +28dBm in high mode, 44.5% PAE is achieved, while in low mode at +16dBm, 21% PAE is achieved with an ACLR1 of −38dBc using WCDMA modulation. For CELL band at +28dBm in high mode, 43.5% PAE is achieved, while in low mode, 21% PAE is achieved at +16dBm with an ACLR1 of nearly −39dBc. Both PAs maintain good performance under load mismatch conditions due to the nature of the balanced structure.
ChemInform Abstract: Diels—Alder Adducts of Medium‐Ring Carbocyclic Dienes Prepared by Rearrangement of Catalytically Generated Cyclic Oxonium Ylides (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Deriving Requirements for Pervasive Well-Being Technology From Work Stress and Intervention Theory: Framework and Case Study (2016)

The presented framework can be used to systematically develop theory-based technology-supported interventions to address work stress. In the area of pervasive systems for well-being, we identified the following six key research challenges and opportunities: (1) performing multi-disciplinary research, (2) interpreting personal sensor data, (3) relating measurable aspects to burn-out, (4) combining strengths of human and technology, (5) privacy, and (6) ethics.
Electrochemical Aminoxyl-Mediated α-Cyanation of Secondary Piperidines for Pharmaceutical Building Block Diversification (2018)

Secondary piperidines are ideal pharmaceutical building blocks owing to the prevalence of piperidines in commercial drugs. Here, we report an electrochemical method for cyanation of the heterocycle adjacent to nitrogen without requiring protection or substitution of the N-H bond. The reaction utilizes ABNO (9-azabicyclononane N-oxyl) as a catalytic mediator. Electrochemical oxidation of ABNO generates the corresponding oxoammonium species, which promotes dehydrogenation of the 2° piperidine to the cyclic imine, followed by addition of cyanide. The low-potential, mediated electrolysis process is compatible with a wide range of heterocyclic and oxidatively sensitive substituents on the piperidine ring and enables synthesis of unnatural amino acids.