gebhart/patrepeval huggingface dataset:
Role of HRTPT in kidney proximal epithelial cell regeneration: Integrative differential expression and pathway analyses using microarray and scRNA‐seq (2021)

Damage to proximal tubules due to exposure to toxicants can lead to conditions such as acute kidney injury (AKI), chronic kidney disease (CKD) and ultimately end-stage renal failure (ESRF). Studies have shown that kidney proximal epithelial cells can regenerate particularly after acute injury. In the previous study, we utilized an immortalized in vitro model of human renal proximal tubule epithelial cells, RPTEC/TERT1, to isolate HRTPT cell line that co-expresses stem cell markers CD133 and CD24, and HREC24T cell line that expresses only CD24. HRTPT cells showed most of the key characteristics of stem/progenitor cells; however, HREC24T cells did not show any of these characteristics. The goal of this study was to further characterize and understand the global gene expression differences, upregulated pathways and gene interaction using scRNA-seq in HRTPT cells. Affymetrix microarray analysis identified common gene sets and pathways specific to HRTPT and HREC24T cells analysed using DAVID, Reactome and Ingenuity software. Gene sets of HRTPT cells, in comparison with publicly available data set for CD133+ infant kidney, urine-derived renal progenitor cells and human kidney-derived epithelial proximal tubule cells showed substantial similarity in organization and interactions of the apical membrane. Single-cell analysis of HRTPT cells identified unique gene clusters associated with CD133 and the 92 common gene sets from three data sets. In conclusion, the gene expression analysis identified a unique gene set for HRTPT cells and narrowed the co-expressed gene set compared with other human renal-derived cell lines expressing CD133, which may provide deeper understanding in their role as progenitor/stem cells that participate in renal repair.
Universal continuous-variable quantum computation without cooling (2017)

One limitation of the quantum computing capability of a continuous-variable system is determined by our ability to cool it to the ground state, because pure logical states, in which we accurately encode quantum information, are conventionally pure physical states that are constructed from the ground state. In this work, we present an alternative quantum computing formalism that encodes logical quantum information in mixed physical states. We introduce a class of mixed-state protocols that are based on a parity encoding, and propose an implementation of the universal logic gates by using realistic hybrid interactions. When compared with the conventional pure-state protocols, our formalism could relax the necessity, and hence the systemic requirements, of cooling. Additionally, the mixed-state protocols are inherently resilient to a wider class of noise processes and reduce the fundamental energy consumption in initialization. Our work broadens the range of candidates for continuous-variable quantum computers.
The 3,3'-bis-pyridinium mono-oximes as antidotes against organophosphorous intoxication. (1992)

In an attempt to develop effective antidotes against organophosphorous intoxication, three new structurally related bispyridinium mono-oximes with a 2-oxopropane bridge were synthesized. The compounds were evaluated for in-vivo therapeutic protection and cholinesterase reactivation in blood and various brain regions. In neuromuscular function studies against diisopropyl-fluorophosphate and isopropyl methylphosphonofluoridate poisoning, the oximes produced significant protection. The compounds produced marked peripheral reactivation and beneficial effects on neuromuscular transmission. The reactivation of cholinesterase in cerebral cortex by the oximes, in spite of their being quaternary salts is a notable feature.
A unified framework for name disambiguation (2008)

Name ambiguity problem has been a challenging issue for a long history. In this paper, we intend to make a thorough investigation of the whole problem. Specifically, we formalize the name disambiguation problem in a unified framework. The framework can incorporate both attribute and relationship into a probabilistic model. We explore a dynamic approach for automatically estimating the person number K and employ an adaptive distance measure to estimate the distance between objects. Experimental results show that our proposed framework can significantly outperform the baseline method.
Effects of improved water supply and sanitation on ascariasis, diarrhoea, dracunculiasis, hookworm infection, schistosomiasis, and trachoma. (1991)

A total of 144 studies were analysed to examine the impact of improved water supply and sanitation facilities on ascariasis, diarrhoea, dracunculiasis, hookworm infection, schistosomiasis, and trachoma. These diseases were selected because they are widespread and illustrate the variety of mechanisms through which improved water and sanitation can protect people. Disease-specific median reduction levels were calculated for all studies, and separately for the more methodologically rigorous ones. For the latter studies, the median reduction in morbidity for diarrhoea, trachoma, and ascariasis induced by water supplies and/or sanitation was 26%, 27%, and 29%, respectively; the median reduction for schistosomiasis and dracunculiasis was higher, at 77% and 78%, respectively. All studies of hookworm infection were flawed apart from one, which reported a 4% reduction in incidence. For hookworm infection, ascariasis, and schistosomiasis, the reduction in disease severity, as measured in egg counts, was greater than that in incidence or prevalence. Child mortality fell by 55%, which suggests that water and sanitation have a substantial impact on child survival. Water for personal and domestic hygiene was important in reducing the rates of ascariasis, diarrhoea, schistosomiasis, and trachoma. Sanitation facilities decreased diarrhoea morbidity and mortality and the severity of hookworm infection. Better water quality reduced the incidence of dracunculiasis, but its role in diarrhoeal disease control was less important than that of sanitation and hygiene.
Studies on the Intramolecular Cyclizations of Bicyclic δ-Hydroxynitriles Promoted by Triflic Anhydride (2007)

Studies have been conducted to investigate the reactivity of several bicyclic delta-hydroxynitriles with triflic anhydride in dichloromethane. The reactions of the analogues derived from 1-indanone and 1-tetralone lead to annulated enones. These products arise from an initial elimination reaction that generates an alkene, followed by the addition of the carbon-carbon double bond to the activated cyano group. The intramolecular cyclization of the derivative obtained from 1-benzosuberone unexpectedly followed a different path, giving a cyclic imidate as the major product. In this case, the activated cyano group is directly attacked by the hydroxyl group of the starting delta-hydroxynitrile. Theoretical calculations provide a rationale for the observed reactivity pattern. Both the formation of the triflate via its protonated form, its subsequent ionization to the carbocation, and the cyclization of the resulting alkene to the enone become less favorable when the size of the ring increases due to conformational effects. The opposite trend is observed for the competing Pinner-type cyclization to the imidate. An alternative mechanism for the formation of the lactams from the cyclic imidates under acid-catalyzed conditions has also been proposed.
Live Cell Interferometry Reveals Cellular Dynamism During Force Propagation (2008)

Cancer and many other diseases are characterized by changes in cell morphology, motion, and mechanical rigidity. However, in live cell cytology, stimulus-induced morphologic changes typically take 10-30 min to detect. Here, we employ live-cell interferometry (LCI) to visualize the rapid response of a whole cell to mechanical stimulation, on a time scale of seconds, and we detect cytoskeletal remodeling behavior within 200 s. This behavior involved small, rapid changes in cell content and miniscule changes in shape; it would be difficult to detect with conventional or phase contrast microscopy alone and is beyond the dynamic capability of AFM. We demonstrate that LCI provides a rapid, quantitative reconstruction of the cell body with no labeling. This is an advantage over traditional microscopy and flow cytometry, which require cell surface tagging and/or destructive cell fixation for labeling.
The control of growth and differentiation in normal and leukemic blood cells (1991)

The establishment of a cell culture system for the clonal development of hematopoietic cells has made it possible to discover the proteins that control growth and differentiation of different hematopoietic cell lineages and the molecular basis of normal and abnormal cell development in blood-forming tissues. A model system with myeloid cells has shown that normal hematopoietic cells require different proteins to induce cell multiplication and cell differentiation, and that a cascade of interactions between proteins determines the correct balance between immature and mature cells in normal development. Gene cloning has shown that there is a family of different genes for these proteins. Normal protein regulators of hematopoiesis can control the abnormal growth of certain types of leukemic cells and suppress malignancy by inducing differentiation to mature nondividing cells. Genetic abnormalities that give rise to malignancy in these leukemic cells can be bypassed and their effects nullified by inducing differentiation, which stops cells from multiplying. These hematopoietic regulatory proteins are active in culture and in vivo and have been used clinically to correct defects in blood cell development. The results provide new approaches to therapy.
Evolution of an Arti cia1 Neural Network Based Autonomous Land Vehicle Controller (1996)

Abstruct- This paper presents an evolutionary method for creating an artificial neural network based autonomous land vehicle controller. The evolved controllers perform better in unseen situations than those trained with an error backpropagation learning algorithm designed for this task. In this paper, an overview of the previous connectionist based approaches to this task is given, and the evolutionary algorithms used in this study are described in detail. Methods for reducing the high computational costs of training artificial neural networks with evolutionary algorithms are explored. Error metrics specific to the task of autonomous vehicle control are introduced; the evolutionary algorithms guided by these error metrics reveal improved performance over those guided by the standard sum-squared error metric. Finally, techniques for integrating evolutionary search and error backpropagation are presented. The evolved networks are designed to control Carnegie Mellon University’s NAVLAB vehicles in road following tasks.
Supplementary Tables S1-S2 from Lipidomic Profiles of Plasma Exosomes Identify Candidate Biomarkers for Early Detection of Hepatocellular Carcinoma in Patients with Cirrhosis (2023)

&lt;p&gt;Supplementary Table S1. Demographic and clinical parameters in 72 participants with cirrhosis (31 with HCC and 41 without HCC). Supplementary Table S2. Relative abundance (%) of the lipid classes detected in non-HCC exosomes, HCC exosomes, non-HCC plasma and HCC plasma.&lt;/p&gt;
56 Gbit/s InGaAlAs-MQW 1300 nm Electroabsorption-Modulated DFB-Lasers with Impedance Matching Circuit (2013)

We have developed electroabsorption modulated DFB Lasers at 1305 nm using an identical InGaAlAs MQW core in the DFB and the EAM section. A 50Ω matching circuit is realized on-chip giving an f3dB of 39.4 GHz. We present 56 Gbit/s eyes with a dynamic extinction ratio of 9.5 dB. The fiber coupled output power under modulation is +5 dBm at 45°C.
Level of Improvement Determined by PODCI is Related to Parental Satisfaction After Single-event Multilevel Surgery in Children With Cerebral Palsy (2010)

Diagnostic level I.
Preliminary design of the soft x-ray array tomographic diagnostic system for Korea Superconducting Tokamak Advanced Research (KSTAR) plasmas (2004)

Analyses of x-ray (SXR) emission from tokamak plasmas provide valuable information about magnetohydrodynamics activities and transport phenomena. In this study, design and optimization of the SXR detector arrays were performed for the KSTAR (Korea superconducting tokamak advanced research) device. Geometrical arrangement of the array system was made by coverage mapping and tomographic reconstruction tests. The space-time tomography algorithm was developed for KSTAR-like plasmas using the fast maximum entropy method combined with singular value decomposition. Spatial setup of the components in each detector array was determined and optimized by geometrical calculation. A curved beryllium window and a developed cooling system will be mounted on the detector arrays. Due to the existence of the complex structures between outer vessel and passive stabilizers, each array is designed to be miniaturized. Hardware-optimization of the array system was cross-checked with the tomographic test results.
The Value of the Selenomethionine Se 75 Scan in Preoperative Localization of Parathyroid Adenomas (1969)

The selenomethionine Se 75 scan was performed in 42 patients with a clinical diagnosis of hyperparathyroidism. The scan correctly localized the abnormal gland in 13 of 23 patients with proven parathyroid adenoma. The parathyroid scan was not helpful in seven patients with parathyroid hyperplasia. Size was the most important factor contributing to visualization of parathyroid adenomas. Adenomas larger than 2 gm were consistently visualized while those weighing less than 1 gm were commonly not detected by the scan. High background over the mediastinum precludes the possibility of detecting most mediastinal adenomas by this technique. The value of the selenomethionine Se 75 parathyroid scan is thus limited in patients with small adenomas or hyperplastic glands and in patients with adenomas or hyperplastic glands lying deep in the thorax.
Production and Characterization of Monoclonal Antibodies to Human Growth Hormone (1987)

Three BIOZZI-HR mice were immunized with human growth hormone (hGH). From the determination of the titer, the average equilibrium association constant and the heterogeneity index of the antisera, it was possible to select the most suitable mouse for production of monoclonal antibodies (Mabs). Resulting from a single fusion, eight Mabs were produced, purified and characterized. The equilibrium association constant of the Mabs ranged from 5.10(8) M-1 to 9.109 M-1 at physiological pH. Four areas on hGH are recognized by the Mabs (the topology of the Mabs was investigated by two-site immunoradiometric assays). The Mabs, which recognize a same area, show similar cross-reactivities between hGH and human Placental Lactogen (hPL). No selected Mabs bound human Prolactin (hPRL), equine Growth Hormone (eGH) and porcine Growth Hormone (pGH). Two complementary Mabs enable a two-site immunometric assay of pituitary and E. Coli derived hGH.
Prospective multicenter trial comparing repeated immunosuppressive therapy with stem-cell transplantation from an alternative donor as second-line treatment for children with severe and very severe aplastic anemia (2007)

We conducted a prospective multicenter study to compare the efficacy of repeated immunosuppressive therapy (IST) with stem-cell transplantation (SCT) from an alternative donor in children with acquired aplastic anemia (AA) who failed to respond to an initial course of IST. Patients with severe (n = 86) and very severe disease (n = 119) received initial IST consisting of antithymocyte globulin (ATG) and cyclosporine. Sixty patients failed to respond to IST after 6 months from the initial IST and were eligible for second-line treatment. Among them, 21 patients lacking suitable donors received a second course of IST. Three patients developed an anaphylactoid reaction to ATG and could not complete the second IST. A trilineage response was seen in only 2 of 18 (11%) evaluable patients after 6 months. Thirty-one patients received SCT from an alternative donor. At 5 years from the initiation of second-line therapy, the estimated failure-free survival (FFS), defined as survival with response, was 83.9% (+/- 16.1%, SD) in the SCT group compared with 9.5% (+/- 9.0%) in the IST group (P = .001). These results suggest that SCT from an alternative donor offers a better chance of FFS than a second IST in patients not responding to an initial IST.
Optical properties of dissipative media (1983)

General expressions for the optical properties of dissipative media are developed within a framework which retains the separate identities of conduction and polarization currents. The resulting formalism thereby facilitates the physical interpretations that the displacement of bound charges produces polarization while at the same time the motion of free carriers produces conduction currents. The ability of the approach to achieve a clear and consistent physical interpretation of the origins of dispersion in semiconductors is then illustrated by application to the Drude–Lorentz electron model. Finally, the results are related to those based on the conventional treatment wherein effective optical properties are introduced and hence the distinction between conduction and polarization currents does not exist.
A quantitative, in vitro appraisal of experimental low-glucose storage solutions used for blood banking (2016)

A combination of 3D printed tools and classic cellular analyses reveals the benefits of reducing the glucose content of currently approved solutions used to process and store red blood cells for transfusion medicine.
CuZn superoxide dismutase activities from Fasciola hepatica (1998)

The levels of superoxide dismutase (SOD) were determined in detergent-soluble, somatic and excretion-secretion (E-S) preparations from adult Fasciola hepatica using the xanthine oxidase system and visualized in substrate gels. Compared to detergent-soluble and somatic extracts, E-S products showed the highest SOD activity (88.5 U/mg), indicating active release to the medium in which parasites were maintained. SOD specific activity was also detected at high levels in E-S products from 3-week-old and 5-week-old immature migrating flukes (25 and 143 U/mg, respectively). In all preparations except for the somatic extract, the activity was characterized as cyanide-sensitive CuZn SOD. Differences in SOD isoenzyme profiles between the extracts were observed in native polyacrylamide gel electrophoresis: the somatic and detergent-soluble extracts exhibited 1 band of activity while the E-S products from immature and adults flukes contained 2 and 3 migrating bands, respectively. SOD was purified from the detergent-soluble extract and E-S products of adult worms by a combination of ultrafiltration, gel filtration on Sephacryl S-200 HR and ion-exchange chromatography on QAE Sephadex A-50. The SOD from detergent-soluble extract showed, by SDS-PAGE analysis, 1 band of 16 kDa apparent molecular weight. The SOD from E-S products showed 2 bands of 16 and 60 kDa apparent molecular weight. N-terminal sequence analysis of the 16 kDa band from the detergent-soluble preparation showed some similarity with Schistosoma mansoni cytoplasmic SOD. These enzymes may have a potential role in the evasion of the oxidative burst killing mechanism by immune cells.
MOLECULAR DISTILLATION Examination of Natural Vitamin D (1938)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMOLECULAR DISTILLATION Examination of Natural Vitamin DK. C. D. Hickman and E. Leb. GrayCite this: Ind. Eng. Chem. 1938, 30, 7, 796–802Publication Date (Print):July 1, 1938Publication History Published online1 May 2002Published inissue 1 July 1938https://pubs.acs.org/doi/10.1021/ie50343a017https://doi.org/10.1021/ie50343a017research-articleACS PublicationsRequest reuse permissionsArticle Views84Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Erratic passage and anchorage of a right subclavian catheter caused by preoccupancy of an indwelling right jugular venous catheter--a case report. (1996)

We report a case of central venous catheter (CVC) malposition. Through subclavian approach the CVC tip was intended to anchor in the superior cava, but it turned out to be in the right internal jugular vein as revealed by chest X-ray. The cause of malposition was perhaps the preoccupancy of the jugular venous CVC which interferred with a normal advancement. Although the malposition of the catheter might not produce any immediate problem, later complication might occur. Thus, removal of a problematic catheter and recatheterization was indicated.
Policy Core Lightweight Directory Access Protocol (LDAP) Schema (2004)

This document defines a mapping of the Policy Core Information Model to a form that can be implemented in a directory that uses Lightweight Directory Access Protocol (LDAP) as its access protocol.This model defines two hierarchies of object classes: structural classes representing information for representing and controlling policy data as specified in RFC 3060, and relationship classes that indicate how instances of the structural classes are related to each other.Classes are also added to the LDAP schema to improve the performance of a client's interactions with an LDAP server when the client is retrieving large amounts of policy-related information.These classes exist only to optimize LDAP retrievals: there are no classes in the information model that correspond to them.
Characterization of the Trichomonas vaginalis surface-associated AP65 and binding domain interacting with trichomonads and host cells (2007)

T. vaginalis AP65 is a secreted, surface-associated protein and a model is proposed to explain how this secreted protein functions as an adhesin.
Supplementary Figure 7 from Hedgehog Signaling Regulates Metabolism and Polarization of Mammary Tumor-Associated Macrophages (2023)

&lt;p&gt;Supplementary Figure 7&lt;/p&gt;
The Connected Car in the Cloud: A Platform for Prototyping Telematics Services (2015)

The Connected-Car Prototyping Platform provides both a back end for applications interacting with connected cars and an abstraction of such connected devices for developers. It also provides services such as identity management and data storage. Its main purposes are experimentation, prototyping, evaluation of ideas, and reduction of time-to-market for successful applications.