gebhart/patrepeval huggingface dataset:
Using a meiosis detection toolkit to investigate ancient asexual “scandals” and the evolution of sex (2008)

Sexual reproduction is the dominant reproductive mode in eukaryotes but, in many taxa, it has never been observed. Molecular methods that detect evidence of sex are largely based on the genetic consequences of sexual reproduction. Here we describe a powerful new approach to directly search genomes for genes that function in meiosis. We describe a "meiosis detection toolkit", a set of meiotic genes that represent the best markers for the presence of meiosis. These genes are widely present in eukaryotes, function only in meiosis and can be isolated by degenerate PCR. The presence of most, or all, of these genes in a genome would suggest they have been maintained for meiosis and, implicitly, sexual reproduction. In contrast, their absence would be consistent with the loss of meiosis and asexuality. This approach will help to understand both meiotic gene evolution and the capacity for meiosis and sex in putative obligate asexuals.
Predicting the DPP-IV Inhibitory ActivitypIC50Based on Their Physicochemical Properties (2013)

The second development program developed in this work was introduced to obtain physicochemical properties of DPP-IV inhibitors. Based on the computation of molecular descriptors, a two-stage feature selection method called mRMR-BFS (minimum redundancy maximum relevance-backward feature selection) was adopted. Then, the support vector regression (SVR) was used in the establishment of the model to map DPP-IV inhibitors to their corresponding inhibitory activity possible. The squared correlation coefficient for the training set of LOOCV and the test set are 0.815 and 0.884, respectively. An online server for predicting inhibitory activity pIC50 of the DPP-IV inhibitors as described in this paper has been given in the introduction.
EFFECTS OF THE ARTHRITIS FOUNDATION AQUATIC PROGRAM (AFAP) ON POSTURAL STABILITY IN WOMEN WITH ARTHRITIS 47 (1996)

The purpose of this study was to examine the effect of a six week AFAP aquatic program on the static and dynamic postural control of women with arthritis. Twenty seven women with arthritis were randomly assigned to a treatment group (AFAP) or a control (C) group. The AFAP group consisted of 17 women (mean age = 59.8 yrs) whereas the C group consisted of 10 women (mean age = 54.4 yrs). The AFAP group participated in a six week aquatic program, consisting of 45 minute session/three times per week. These sessions were conducted in a heated therapeutic pool, and are designed to increase strength, range of motion and mobility. Prior to and at the end of the six week session, all subjects were examined on static and dynamic postural stability utilizing a Kistler force platform and custom designed software (sample rate = 50 Hz). Results indicated that for static postural stability, the AFAP group demonstrated significant decreases in total sway area (F1,25 = 4.28, p=.049) and lateral sway (F1,25 = 11.03, p =.003), whereas the C group did not change. For the dynamic condition, the AFAP group demonstrated quicker recovery times (F1,25 = 5.15, p =.032). These results demonstrate that the AFAP intervention program increases static and dynamic postural stability in women with arthritis.
Substructure Texture Evolution and Dynamic Abnormal Grain Growth in a Mo Rod Material. (2020)

Abstract not provided.
Immune privilege of skin stem cells: What do we know and what can we learn? (2020)

The skin forms a barrier that prevents dehydration and keeps us safe from pathogens. To ensure proper function, the skin possesses a myriad of stem cell populations that are essential for maintenance and repair upon damage. In order to protect, the skin is also an active immunological site, with abundant resident immune cells and strong recruitment of even more immune cells during wounding or infection. Such active and strong immunity makes the skin susceptible to a diverse spectrum of autoimmune diseases, such as vitiligo and alopecia areata. Conversely, despite constant immune surveillance, the skin is also a tissue where frequent malignancies occur, which suggests that immune evasion must also take place. Skin stem cells play a crucial role during both regeneration and tumorigenesis. How immune cells, and in particular T cells, interact with skin stem cells and the implications this crosstalk has in skin disease (both autoimmunity and cancer) is not fully understood. Uncovering the mechanisms governing immune-stem cells interactions in the skin is critical for the development of new therapeutic strategies to safeguard susceptible cells during autoimmunity and, conversely, to improve cancer immunotherapy. Here, I will discuss how distinct skin stem cell populations are attacked by, or conversely, cloaked from immune cells, and the implications their differences have in autoimmunity and cancer.
Energy-efficient PON system with a 1Gbps/10Gbps independent and adaptive link rate control (2011)

In this paper, we propose an independent and adaptive link rate control for a 1Gbps/10Gbps hybrid PON, where the low power consumption 1Gbps transceivers are maximally used even when incoming traffic reaches the given threshold. We show effectiveness of our proposed method in terms of energy efficiency through simulation experiments.
Effect of atorvastatin on the cortical bones of corticosteroid treated rabbits (2011)

Osteoporosis ("secondary" osteoporosis) and avascular necrosis (AVN) of the femoral head are well-known adverse effects of corticosteroid therapy. Statins have been reputed to increase bone strength and bone density. In this study, we evaluated the effect of atorvastatin calcium on the flexural properties (3-point bending strength and modulus) of corticosteroid (methylprednisolone acetate) treated rabbit femurs and tibias. Our study hypothesis was that the use of statins would counteract the loss of bone strength caused by corticosteroid treatment. The 40 rabbits were divided into 5 groups: control, corticosteroid alone and corticosteroid combined with oral doses of atorvastatin calcium (2, 10, or 20 mg/day). A daily oral dose of atorvastatin calcium treatment for 70 days weakened the long bones of methylprednisolone acetate treated rabbits irrespective of the dosage (2, 10, or 20 mg). Cortical bone strength was assessed using the 3-point bending test at the end of the study period. A daily oral dose of atorvastatin calcium did not attenuate the loss of cortical bone strength caused by corticosteroid treatment in rabbits. It appeared to decrease that bone strength. If these results hold true in humans, they would have wide applicability given the frequent combined use of corticosteroids and statins in many patients.
Recording unit of squid-based magnetometer (1987)

HealthStar Network established a new concept in its eastern market--a group of hospitals forming one association. Marketers of HealthStar are conducting a branding campaign to distinguish individual expertise under one umbrella company.
[Migrating multiple mononeuritis and nonsystemic angitis]. (1989)

Multiple mononeuritis of migrating nature at onset occurs in a variety of disease conditions. "Migrant sensory neuritis" without a systemic underlying disorder described by Wartenberg (1958) is the most distinctive form of this type of neuropathy. Its pathomechanism is not uniform, but angiopathy has been suggested by Matthews et al. (1981). In this report, we describe five cases of sensory-dominant multiple mononeuritis with migrating nature and without systemic visceral involvement. The patients consisted of four females and one male between 26 and 71 years of age. All showed recurrent episodes of sensory involvement along the distal branches of the cutaneous nerve. The patients presented with sudden onset of numbness or pain radiating along the cutaneous branches of the involved nerves often followed by persistent sensory deficit. In mild episodes, the sensory symptom with numbness almost completely subsided. The frequency of these episodes ranged from 7 times in 6 months to 6 times in 9 years. The clinical manifestations were similar or identical to those of migrant sensory neuritis reported by Watenberg and Matthews et al. Cranial nerve involvement and less frequent episodes in the present series differed from those in the previous reports. Laboratory examinations did not disclose any underlying disorder, suggesting systemic collagen vascular disease. Sural nerve biopsy study in two patients revealed vasculitis in small or medium-sized arteries in the epineurium as well as reduced population of large myelinated fibers. Small myelinated fibers were slightly increased in number, probably to regenerating fibers. Sensory action potentials were low or not evoked in the nerves examined.(ABSTRACT TRUNCATED AT 250 WORDS)
Modulation of axon diameter and neurofilaments by hypomyelinating Schwann cells in transgenic mice (1994)

Studies of peripheral nerves in two different lines of hypomyelinating transgenic mice support the hypothesis that myelinating Schwann cells exert a significant influence on key biological properties of axons. The mice contain transgenes combining the peripheral myelin protein zero gene (P0) promoter and either the diphtheria toxin A chain gene product or the SV40 (simian virus 40) large T antigen. The consequences of peripheral nerve hypomyelination on axon diameter, neurofilament (NF) density, and NF phosphorylation were analyzed. The sciatic nerves of the P0 diphtheria toxin A transgenic mice (DT) evidenced the most severe hypomyelination, and this was associated with a dramatic decrease in NF phosphorylation plus a marked increase in NF density. In contrast, the sciatic nerves in the P0 SV40 large T antigen transgenic mice (SV40) were not as severely hypomyelinated and there was a milder decrease in NF phosphorylation plus a more modest increase in NF density. Further, the sciatic nerves in both lines evidenced a decrease in axonal caliber without any change in NF content. Taken together, these studies provide strong evidence indicating that myelinating Schwann cells exert a significant influence on axon caliber by modulating NF phosphorylation and NF packing density in the axons of peripheral nerves. Thus, key biological properties of axons are modulated by signals transmitted from myelinating Schwann cells to axons of peripheral nerves.
Eco-Friendly and Solvent-Less Mechanochemical Synthesis of ZrO2–MnCO3/N-Doped Graphene Nanocomposites: A Highly Efficacious Catalyst for Base-Free Aerobic Oxidation of Various Types of Alcohols (2020)

In recent years, the development of green mechanochemical processes for the synthesis of new catalysts with higher catalytic efficacy and selectivity has received manifest interest. In continuation of our previous study, in which graphene oxide (GRO) and highly reduced graphene oxide (HRG) based nanocomposites were prepared and assessed, herein, we have explored a facile and solvent-less mechanochemical approach for the synthesis of N-doped graphene (NDG)/mixed metal oxide (MnCO3–ZrO2) ((X%)NDG/MnCO3–ZrO2), as the (X%)NDG/MnCO3–ZrO2 nano-composite was synthesized using physical grinding of separately synthesized NDG and pre-calcined (300 °C) MnCO3–ZrO2 via green milling method. The structures of the prepared materials were characterized in detail using X-ray powder diffraction (XRD), Field Emission Scanning Electron Microscope (FESEM), Energy Dispersive X-Ray Analysis (EDX), Fourier-transform infrared spectroscopy (FTIR), Raman, Thermogravimetric analysis (TGA), and N2 adsorption-desorption isotherm analysis. Besides, the obtained nanocomposites were employed as heterogeneous oxidation catalyst for the alcohol oxidation using green oxidant O2 without involving any surfactants or bases. The reaction factors were systematically studied during the oxidation of benzyl alcohol (PhCH2OH) as the model reactant to benzaldehyde (PhCHO). The NDG/MnCO3–ZrO2 exhibits premium specific activity (66.7 mmol·g−1·h−1) with 100% conversion of PhCH2OH and &gt; 99.9% selectivity to PhCHO after only 6 min. The mechanochemically prepared NDG based nanocomposite exhibited notable improvement in the catalytic efficacy as well as the surface area compared to the pristine MnCO3–ZrO2. Under the optimal circumstances, the NDG/MnCO3–ZrO2 catalyst could selectively catalyze the aerobic oxidation of a broad array of alcohols to carbonyls with full convertibility without over-oxidized side products like acids. The NDG/MnCO3–ZrO2 catalyst were efficiently reused for six subsequent recycling reactions with a marginal decline in performance and selectivity.
Efficacy of Clindamycin Vaginal Ovule (3‐Day Treatment) vs.Clindamycin Vaginal Cream (7‐Day Treatment) in Bacterial Vaginosis (2000)

A 3-day course of clindamycin vaginal ovules is as effective and well-tolerated as a 7-day course of clindamycin vaginal cream in the treatment of BV.
Transplantation of Mesenchymal Stem Cells Improves Cardiac Function in a Rat Model of Dilated Cardiomyopathy (2005)

MSC transplantation improved cardiac function in a rat model of DCM, possibly through induction of myogenesis and angiogenesis, as well as by inhibition of myocardial fibrosis. The beneficial effects of MSCs might be mediated not only by their differentiation into cardiomyocytes and vascular cells but also by their ability to supply large amounts of angiogenic, antiapoptotic, and mitogenic factors.
Synthesis of silver nanoparticles in melts of amphiphilic polyesters (2013)

The current work presents a one-step procedure for the synthesis of amphiphilic silver nanoparticles suitable for production of silver-filled polymeric materials. This solvent free synthesis via reduction of Tollens' reagent as silver precursor in melts of amphiphilic polyesters consisting of hydrophilic poly(ethylene glycol) blocks and hydrophobic alkyl chains allows the production of silver nanoparticles without any by-product formation. This makes them especially interesting for the production of medical devices with antimicrobial properties. In this article the influences of the chain length of the hydrophobic block in the amphiphilic polyesters and the process temperature on the particle size distribution (PSD) and the stability of the particles against agglomeration are discussed. According to the results of spectroscopic and viscosimetric investigations the silver precursor is reduced to elemental silver nanoparticles by a single electron transfer process from the poly(ethylene glycol) chain to the silver ion.
Single frequency operation of continuous-wave high-power Optically-Pumped Semiconductor Lasers (2013)

We report on our research in power scaling OPSL around 1µm to exceed 100W per chip by combining a rigorous quantum design of an optimized MQW epitaxial structure, highly accurate and reproducible wafer growth and an efficient thermal management strategy. Recently, we have utilized these state-of-the-art optimized OPSL chips to achieve a new record single frequency output power of 15W. The highly coherent TEM00 mode exhibit a M2 of 1.2 with a very narrow linewidth (&lt;7.5MHz).
Homoharringtonine, an approved anti-leukemia drug, suppresses triple negative breast cancer growth through a rapid reduction of anti-apoptotic protein abundance (2019)

International audience
Syn addition of dialkyl diselenide to phenylacetylene in the presence of tin tetrachloride (2002)

The tin tetrachloride-mediated reaction of dialkyl diselenides with phenylacetylene proceeds as syn addition to afford' 2a,b.
<title>Realistic world of limited sample neural network applications: how to proceed on a firm methodological foundation with small-n</title> (1994)

Improving evaluation, especially with small sample, or small-n, applications, may be highly dependent on incorporating expanding knowledge about methodological pitfalls to avoid. It is the intent of the current paper to provide an informational guide to key evaluation issues with small-n. Although the present paper is focused on supervised learning classification paradigms typified by the back-propagation network, the principles hold true in various degrees for other artificial neural networks.
Multiband Microstrip Antennas with Folded Slot (2002)

あらまし 本論文では,まずマイクロストリップアンテナ(以下,MSA と略記)に着目し,その放射素子部 の端部近傍の領域に折曲げ構造のスロットを装荷し,多周波共用特性を実現させるアンテナ系を研究対象に取り 上げ,その構成法と放射特性についてシミュレーションと実験の両面より検討を加えた.すなわち,本研究にお ける主要な考察事項は,( 1)2 周波共用 MSA の構成法と放射特性について,モーメント法による電磁界シミュ レータにより詳細な検討を加え,その設計基礎資料を得るとともに,得られた設計基礎資料の妥当性を実験によ り検証したこと.( 2)多周波共用特性を実現させるため,MSA素子の内部領域に 2 本の折曲げスロットを装荷 するアンテナ系に着目し,その構成法と放射特性についても電磁界シミュレータにより詳細に検討を加え,この 種のアンテナ系を構成する際重要となる設計パラメータを明らかにし,かつ,それらの設計資料の妥当性を実験 により検証したことなどである. キーワード マイクロストリップアンテナ,折曲げスロット,2 周波共用,多周波共用,平面アンテナ
Efficient and Effective Duplicate Detection in Hierarchical Data (2012)

Although there is a long line of work on identifying duplicates in relational data, only a few solutions focus on duplicate detection in more complex hierarchical structures, like XML data. In this paper, we present a novel method for XML duplicate detection, called XMLDup. XMLDup uses a Bayesian network to determine the probability of two XML elements being duplicates, considering not only the information within the elements, but also the way that information is structured. In addition, to improve the efficiency of the network evaluation, a novel pruning strategy, capable of significant gains over the unoptimized version of the algorithm, is presented. Through experiments, we show that our algorithm is able to achieve high precision and recall scores in several data sets. XMLDup is also able to outperform another state-of-the-art duplicate detection solution, both in terms of efficiency and of effectiveness.
Total Synthesis of Neohedycaryol. Its Possible Role in the Biosynthesis of Eudesmane Sesquiterpenes (1997)

The total synthesis of neohedycaryol (4), the C(9)-C(10) double bond regioisomer of the germacrane sesquiterpene hedycaryol, was accomplished in 10 steps from the known dione 6. A Marshall fragmentation of the intermediate mesylate 14 was used to prepare the trans,trans-cyclodeca-1,6-diene ring present in neohedycaryol. During the synthesis of 14, a pronounced example of through-bond interactions (TBI) was observed. The preferred elongated chair conformation of neohedycaryol was demonstrated spectroscopically and by chemical conversion into alpha-, beta-, and gamma-eudesmol. These findings indicate that the occurrence of neohedycaryol as a precursor in the biosynthesis of epi-eudesmanes as proposed in the literature is unlikely. The preference of neohedycaryol for the elongated chair conformation further shows that the compound occupies the meso form. This implies that neohedycaryol may act as a precursor in the biosynthesis of both ent- and usual eudesmanes.
The preparation of n‐methyldiethanolamine and Nmethyl‐2:2′‐ dichlorodiethylamine (1949)

Abstract Optimum conditions have been determined for the preparation of N‐methyldiethanolamine, without serious contamination by higher homologues, by condensation of ethylene oxide with aqueous methylamine: 1 The conversion of the diol into N‐methyl‐2: 2′‐dichlorodiethylamine has also been investigated.
Supplementary Figures S5-S6 from Microtubule-Associated Protein-tau is a Bifunctional Predictor of Endocrine Sensitivity and Chemotherapy Resistance in Estrogen Receptor–Positive Breast Cancer (2023)

Supplementary Figures S5-S6 from Microtubule-Associated Protein-tau is a Bifunctional Predictor of Endocrine Sensitivity and Chemotherapy Resistance in Estrogen Receptor–Positive Breast Cancer
Some factors affecting the activities of dinitrophenol fungicides. II.—Use of g.l.c. partition data in studies of chemical structure/fungicidal activity against powdery mildew (1971)

Abstract The application of partition data, derived by a gas‐liquid chromatographic (g.l.c.) technique, to the study of the activities of members of homologous 4‐(l‐substituted alkyl)‐2,6‐dinitrophenol series against cucurbit and apple powdery mildews (caused by Oidium sp. and Podosphaera leucotricha respectively) is discussed. The correlation between the possession of high protectant activity and a favourable πglc value for maximum ‘zonal’ movement within the leaf surface is stressed. This criterion is more important than vapour‐phase activity in this context; it may well rival in importance the possession of optimum conidial penetration properties.
Joint power-playout control for media streaming over wireless links (2006)

Media streaming applications over wireless links face various challenges, due to both the nature of the wireless channel and the stringent delivery requirements of media traffic. In this paper, we seek to improve the performance of media streaming over an interference-limited wireless link, by using appropriate transmission and playout control. In particular, we choose both the power at the transmitter and the playout scheduling at the receiver, so as to minimize the power consumption and maximize the media playout quality. We formulate the problem using a dynamic programming approach, and study the structural properties of the optimal solution. We further develop a justified, low-complexity heuristic that achieves significant performance gain over benchmark systems. In particular, our joint power-playout heuristic outperforms: 1) the optimal power control policy in the regime where power is most important and 2) the optimal playout control policy in the regime where media (playout) quality is most important; furthermore, this heuristic has only a slight performance loss as compared to the optimal joint power-playout control policy over the entire range of the investigation
Wind Farm Wake Simulations in OpenFOAM (2010)

In an effort to lower the cost of energy for wind power, wake power losses need to be better predicted. As turbines extract energy from wind, a wake of slower, more turbulent flow is created downstream of the turbine. Because of lower local wind speeds, turbines located in the wake of another turbine do not produce as much power as the upstream turbine. Current modeling efforts fail to accurately predict power losses in downstream turbines by not completely capturing wake effects. Further research to understand and model wake effects is necessary to reduce wake power losses and improve overall wind farm power production. A model is created that simulates a neutrally stratified atmospheric boundary layer (ABL). The neutral ABL simulation is validated against three criteria from experimental data. The model is run using both Large Eddy Simulation (LES) and Reynolds Averaged Navier-Stokes (RANS) solvers to compare the two methods as well as to the commonly used empirical Park model. Wind turbines at various downstream positions are modeled within the neutral ABL simulation using an actuator disc. Results from this model include the power deficit ratio of a turbine located in a wake. Power deficit ratios for LES and RANS simulations are within 2-4% and 15-43% of experimental data, respectively. With the results from these simulations, researchers can improve lower-order models to more accurately represent hundreds of turbines in an entire wind farm and improve efficiency.