gebhart/patrepeval huggingface dataset:
Crack characterization using guided circumferential waves (2001)

This paper examines the propagation of guided circumferential waves in a hollow isotropic cylinder that contains a crack, with the goal of using these guided waves to both locate and size the crack. The crack is sized using a modified Auld's formula, which relates the crack's length to a reflected energy coefficient. The crack is then located by operating on the backscattered signal with a time-frequency digital signal processing (DSP) technique, and then comparing these results to those obtained if the cylinder is perfect. The guided circumferential waves are generated with a commercial finite element method (FEM) code. One objective of this work is to demonstrate the effectiveness of using sophisticated DSP techniques to describe the effect of scattering on dispersive waves, showing it is possible to characterize cracks systematically and accurately by quantifying this scattering effect. The results show that the need for high frequency signals to detect small cracks is significantly decreased by using these techniques.
Supplementary figure legend from ImmunoPET with Anti-Mesothelin Antibody in Patients with Pancreatic and Ovarian Cancer before Anti-Mesothelin Antibody–Drug Conjugate Treatment (2023)

&lt;p&gt;Supplementary figure legend&lt;/p&gt;
Relationship between serum 25-hydroxyvitamin D concentration and risks of metabolic syndrome in children and adolescents from Korean National Health and Nutrition Examination survey 2008-2010 (2015)

Low serum 25(OH)D level is associated with an increase of insulin resistance and metabolic syndrome in children and adolescents.
Enzyme Histochemical Studies on the Hypothalamus of Spontaneously Hypertensive Rates : With Special Reference to That of Rats Subjected to Various Endocrinc Interferences (1966)

Enzyme histochemical studies were performed on the hyhothalamus of spontaneously hypertensive rats (OKAMOTO and AOKI) in the pre-hypertensive stage (40 to 60 days after birth). Each positive finding in spontaneously hypertensive rats was obtained by comparing it to the reaction of normotensive Wistar strain rats with almost the same survival duration. On the other hand, in order to clarify the meaning of the findings thus obtained in spontaneously hypertensive rats, the hypothalamus of normotensive Wistar strain adult rats subjected to various endocrine interferences were similarly examined histochemically and compared with the reaction of the control adult rats. 1) As far as the normal distribution of enzyme activities in the hypothalamus is concerned, acid phosphatase activity was clearly demonstrated in the cytoplasma of nerve cells in contrast with glial substances. Most prominent staining was found in nerve cells of Nucl. paraventricularis and Nucl. supraopticus. Nucl. perifornicalis and Nucl. mamillaris prelateralis were stained relatively deeply. Most of the others were stained moderately. By diphosphopyridine nucleotide diaphorase activity determination, all hypothalamic nuclei showed more or less the activity in the perikaryon of nerve cells. Monoamine oxidase activity was mainly detected diffusely in neuropils and hardly demonstrated in the perikaryon. 2) By enzyme histochemical studies on the hypothalamus of spontaneously hypertensive rats in the pre-hypertensive stage, increase of acid phophatase activity was observed in Nucl. preopticus pars lateralis, Nucl. supraopticus, Nucl. ventromedialis pars anterior, medialis, centralis et lateralis, Nucl. dorsomedialis, Nucl. perifornicalis, Area lateralis hypothalami pars tuberalis, Nucl. arcuatus pars tuberalis et mamillaris, Nucl. posterior hypothalami, Nucl. mamillaris prelateralis, Nucl. supramamillaris and Nucl. mamillaris medialis. Increase of diphosphopyridine nucleotide diaphorase activity was detected in Nucl. premamillaris dorsalis, Nucl. premamillaris ventralis and decrease of the activity was noted in Nucl. arcuatus pars mamillaris and Nucl. mamillaris lateralis. Enhancement of monoamine oxidase activity was observed in Nucl. arcuatus pars tuberalis, Nucl. ventromedialis pars medialis, centralis et lateralis and the activity was reduced in Nucl. suprachiasmaticus and Nucl. mamillaris prelateralis.
T-bet-Expressing B Cells Are Positively Associated with Crohn's Disease Activity and Support Th1 Inflammation (2016)

Pathogenesis of Crohn's disease (CD) is thought to involve the chronic activation of T helper 1 (Th1)- and Th17-mediated inflammation, such as the production of interferon-gamma (IFN-γ) and interleukin 17 (IL-17). However, studies have also shown that although IFN-γ is required, IFN-γ-producing or T-bet-expressing Th1 cells are dispensable. We therefore examined T-bet-expressing B cells as another source of IFN-γ that potentially supported intestinal inflammation in CD patients. We found that the frequencies of T-bet-expressing B cells were significantly upregulated and abundantly present in the gut of active, but not quiescent, CD patients. The frequencies of T-bet-expressing B cells were also directly correlated with CD disease activity. These T-bet<sup>+</sup> B cells were almost exclusively IgG expressing and produced significantly higher amounts of IFN-γ, IL-6, and IL-12 than IgA- and IgM-expressing T-bet<sup>-</sup> B cells. These B cells also supported IFN-γ production of CD4<sup>+</sup> T cells. T-bet expression was induced in vitro in peripheral blood B cells through the stimulation of B-cell receptor (BCR), Toll-like receptor 7 (TLR7), and IFN-γ, which resembled gut T-bet<sup>+</sup> B cells in terms of elevated IFN-γ. We found that these stimulated B cells, but not unstimulated B cells, supported the IFN-γ and IL-12 production from autologous CD4<sup>+</sup> T cells. In addition, in patients with higher gut T-bet<sup>+</sup> B-cell percentage, a higher frequency of gut-infiltrating IFN-γ<sup>+</sup> and IL-12<sup>+</sup> T cells was also observed. Together, our results suggested that T-bet-expressing B cells could contribute to the intestinal Th1 inflammation in CD patients.
Strain-field effects on the formation and migration energies of self interstitials inα-Fefrom first principles (2010)

Ab initio electronic structure calculations are employed to study the stability and mobility of mono-self interstitial atoms (SIA) in $\ensuremath{\alpha}\text{-Fe}$ under external deformation. The ab initio results indicate that the volumetric and uniaxial strain dependences of the SIA formation energy are different in the expansion and compression regimes, in contrast to the linear behavior in continuum elasticity theory. We find a $⟨111⟩\ensuremath{\rightarrow}⟨100⟩$ SIA reorientation mechanism induced by uniaxial expansion which proceeds via $⟨11x⟩{\ensuremath{\mid}}_{x=2.7}$ configuration. Volumetric and uniaxial deformations are also found to have a considerable influence on the migration paths and activation energy barriers for the $⟨110⟩{110}\ensuremath{\leftrightarrow}⟨100⟩{100}$ transformation and the $⟨111⟩\ensuremath{\leftrightarrow}⟨100⟩$ reorientation. The results reveal that (i) the volumetric expansion (compression) decreases (increases) substantially the migration energy barrier and renders the diffusion process three (one) dimensional, (ii) the uniaxial strain removes (decreases) the migration energy barrier for the $⟨111⟩\ensuremath{\rightarrow}⟨11x⟩{\ensuremath{\mid}}_{x=2.7}(⟨11x⟩{\ensuremath{\mid}}_{x=2.7}\ensuremath{\rightarrow}⟨100⟩)$ transformation, leading to spontaneous reorientation of the $⟨111⟩$ SIA, and (iii) the uniaxial deformation breaks the cubic symmetry of the system and in turn induces anisotropy of the migration rates along different directions. These calculations demonstrate that changes in the electronic structure induced by global elastic deformation lead to additional contributions to the formation and migration energies, which cannot be adequately accounted for neither by elasticity theory nor by empirical interatomic potentials.
Transfer and Uptake of Alfentanil in the Human Placenta During In Vitro Perfusion (1994)

Alfentanil, a short-acting lipophilic opioid, is used for labor analgesia and cesarean section and may cause neonatal depression. However, direct placental alfentanil transfer has not been studied. We measured placental alfentanil transfer and uptake during in vitro perfusion. Placenta lobules from healthy parturients were perfused with biophase at pH 7.4, 95%:5% O2:CO2. Maternal to fetal (MTF, n = 10) and fetal to maternal (FTM, n = 10) transfer were examined during perfusion with alfentanil 10 ng/mL, antipyrine, and creatinine for 1 h. Thereafter, both MTF and FTM placentas were assayed for alfentanil content (n = 3), or perfused with biophase for 1 h to determine drug washout and then assayed for alfentanil content (n = 3). After the 1 h washout, the remaining MTF placentas (n = 4) were then perfused MTF with high-dose alfentanil 1000 ng/mL to assess saturability of placental transfer. The remaining FTM placentas (n = 4) were then perfused with alfentanil 10 ng/mL in the MTF direction to verify that the same alfentanil transfer characteristics found between placentas were valid when the direction of drug transfer was reversed in the same placenta. Alfentanil was rapidly transferred (< 5 min) across the placenta both MTF and FTM. During MTF transfer, fetal effluent reached a plateau at 2.2 ng/mL between 35 and 55 min, and was unmeasurable 30 min into washout. During FTM transfer, maternal effluent reached a plateau at 1.9 ng/mL at 25-45 min, and was absent after 20-45 min of washout.(ABSTRACT TRUNCATED AT 250 WORDS)
ChemInform Abstract: Visualizing the Role of Bi 6s “Lone Pairs” in the Off‐Center Distortion in Ferromagnetic BiMnO3 (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Histological diagnosis of precancerous lesions of the stomach: a reliability study (1997)

These results confirm that misclassification of histological diagnosis may be a relevant problem in chemoprevention trials of stomach cancer, more so when baseline diagnosis is taken into account in the analysis to estimate progression and regression rates of precancerous lesions. Further, the results suggest that misclassification is limited to early lesions, while diagnostic reliability of severe lesions is quite high.
Electron paramagnetic resonance of heterogeneous chromium catalysts (1996)

The X- and Q-band EPR spectra of Cr5+ and Cr3+ ions in heterogeneous Cr catalysts have been investigated as a function of the support type and composition (silica, silica–alumina, alumina, mordenite and AlPO-5). A spin-Hamiltonian operator for each of the observed types of resonances is proposed and discussed, while the extensive use of computer-simulated spectra provides detailed information on the nature of supported Cr ions. Mononuclear Cr5+ ions (γ-signal), with g-values ca. 2, are axial on alumina and silica–alumina, and rhombic on silica and mordenite. Two different X-band EPR signals of Cr3+ ions are present on amorphous and crystalline oxidic surfaces: a broad signal with g around 2 and zero field parameters D and E equal to 0, due to clustered Cr3+(β-signal) or isolated octahedral Cr3+ complexes, and a signal with a positive lobe in the region g= 3.5–5.5 (δ-signal). The latter signal is characterized by high values of D and E and due to the presence of a highly distorted Cr3+ octahedron. The data so obtained allow us to develop a general model of supported Cr5+ and Cr3+ ions on oxidic surfaces.
Multibuffers Multiobjects Optimal Matching Scheme for Edge Devices in IIoT (2021)

Environments built from the edge-based Industrial Internet of Things (IIoT) are maelstroms of information that continuously flows between heterogeneous data objects, such as sensors and devices, and edge nodes. However, the explosive growth in the number of IIoT data objects connected to edge nodes generally results in significant computation and storage requirements, which exceed those of resource-constrained edge nodes. The problem mentioned above causes a major concern related to efficient memory usage and faster communication processing in data acquisition. Therefore, in this article, we propose a multibuffers multiobjects (MBMOs) architecture to support the parallel delivery of multiple data objects to multiple variable-length buffer blocks. Furthermore, a mathematical model is established, aiming to find the optimum buffer according to the size of each communication data packet. For the aforementioned matching problem, a spatiotemporal resource allocation algorithm is designed to maximize memory usage while minimizing communication processing time. We implement our MBMO in a monitoring system in which embedded programmable logic controllers (ePLCs) serve as the edge nodes. The analyses illustrate that memory usage and time efficiency are improved greatly with the utilization of MBMO.
Parallel Computing Techniques for High-Performance Probabilistic Record Linkage (2002)

Record linkage techniques are used to link together records from one or more data sets relating to the same entity, e.g. patient or customer. As data is often not primarily collected for data analysis purposes, a common unique identifier is missing in many cases, and probabilistic linkage techniques have to be applied. Historical collections of administrative and other (health) data nowadays contain tens of millions of records, with new data being added at the rate of millions of records per year. Although improvements in available computing power have to some extent mitigated against the effects of this accelerating growth in the size of the data sets to be linked, large-scale probabilistic record linkage is still a slow and resource-intensive process. The ANU
Clinical Experience With a New Fast-Resorbing Polymer for Bone Stabilization in Craniofacial Surgery (2006)

Polylactic acid (PLA) and polyglycolic acid have been successfully used as suture material during the past 30 years and have been successfully used in various orthopedic and craniofacial applications, with increasing frequency during the past 15 years. To eliminate some of the problems seen with the longer-lasting Macropore PLA product and other longer-lasting resorbable systems, a new fast-resorbing polymer (FRP) was manufactured by Macropore-Medtronic Neurologic Technologies, Inc. from commercially available 85:15 poly(D,L-lactide-co-glycolide) raw material using traditional melt-processing techniques. The delivery system is easily used and uses essentially the same instrumentation. One hundred and sixty eight patients who had implantation of the FRP were studied. Detailed clinical evaluation was completed after surgery and at each postoperative visit. Overall, there was a 2.1% implant-related complication rate, which compared favorably to the 8.5% implant-related complication rate associated with the longer-lasting PLA product. All patients who received FRP implants have had maintenance of stable bony fixation, followed by bony healing and satisfactory or excellent cosmetic results. The results from the FRP study indicate that the FRP material and implants are safe and effective in craniomaxillofacial applications.
Individualized Prediction of Transition to Psychosis in 1,676 Individuals at Clinical High Risk: Development and Validation of a Multivariable Prediction Model Based on Individual Patient Data Meta-Analysis (2019)

<b>Background:</b> The Clinical High Risk state for Psychosis (CHR-P) has become the cornerstone of modern preventive psychiatry. The next stage of clinical advancements rests on the ability to formulate a more accurate prognostic estimate at the individual subject level. Individual Participant Data Meta-Analyses (IPD-MA) are robust evidence synthesis methods that can also offer powerful approaches to the development and validation of personalized prognostic models. The aim of the study was to develop and validate an individualized, clinically based prognostic model for forecasting transition to psychosis from a CHR-P stage. <b>Methods:</b> A literature search was performed between January 30, 2016, and February 6, 2016, consulting PubMed, Psychinfo, Picarta, Embase, and ISI Web of Science, using search terms ("ultra high risk" OR "clinical high risk" OR "at risk mental state") AND [(conver* OR transition* OR onset OR emerg* OR develop*) AND psychosis] for both longitudinal and intervention CHR-P studies. Clinical knowledge was used to <i>a priori</i> select predictors: age, gender, CHR-P subgroup, the severity of attenuated positive psychotic symptoms, the severity of attenuated negative psychotic symptoms, and level of functioning at baseline. The model, thus, developed was validated with an extended form of internal validation. <b>Results:</b> Fifteen of the 43 studies identified agreed to share IPD, for a total sample size of 1,676. There was a high level of heterogeneity between the CHR-P studies with regard to inclusion criteria, type of assessment instruments, transition criteria, preventive treatment offered. The internally validated prognostic performance of the model was higher than chance but only moderate [Harrell's C-statistic 0.655, 95% confidence interval (CIs), 0.627-0.682]. <b>Conclusion:</b> This is the first IPD-MA conducted in the largest samples of CHR-P ever collected to date. An individualized prognostic model based on clinical predictors available in clinical routine was developed and internally validated, reaching only moderate prognostic performance. Although personalized risk prediction is of great value in the clinical practice, future developments are essential, including the refinement of the prognostic model and its external validation. However, because of the current high diagnostic, prognostic, and therapeutic heterogeneity of CHR-P studies, IPD-MAs in this population may have an limited intrinsic power to deliver robust prognostic models.
SVD-BASEDFILTERINGOF NOISEINHARMONICS WITH WAVELET (2007)

Inthis paperweperformed assessment ofbothWavelet andSVDbased techniques andproposed ahybrid method bycombining wavelet andSVDforthefiltering ofnoise inHarmonics. Inthefirst stepofthealgorithm, Wavelet Denoising isapplied tothenoisy signal aspre-processing (Gross Filtering) step.Singular ValueDecomposition is thenapplied toadatamatrix formed fromthedenoised signal. Thefiltered signal isrecovered fromthesignal truncated SVDsubspace ofthis data matrix. Performance ofeachscheme hasbeenevaluated bysimulation onthe basis ofrelative meansquare error.
Pneumatic Transportation of Powder in Horizontal Pipelines (1989)

The present work was undertaken in order to improve the feeding of the test dust dispersion into a cyclone separator. In order to solve the problem of deposition of the test dust in inlet pipes, a comprehensive investigation was carried out taking the powder mixing into account. With regard to the powder transportation, the effects of pertinent variables such as flow velocity, mass loading and amount of dispersant were closely examined. This work showed that the tapped density may be a decisive property to estimate the quality of dispersion of the admixed powder with dispersant. It was also found that the effective flow velocity to transport powder must be 2∼3 times greater than the semi-theoretical and empirical estimations available in the open literature
Endothelial activation--a strategic event during postischemic myocardial inflammation. (2000)

Reperfusion after limited ischemia increases leukocyte adhesion, which may contribute to postischemic myocardial and endothelial stunning. Leukocyte adhesion is enhanced immediately after the onset of reperfusion, indicating rapid regulatory mechanisms. In addition, de novo synthesis of, e.g., adhesion molecules induced by reperfusion has been described, providing a prolonged postischemic inflammatory reaction. Enhanced transcription of adhesion molecules involves NF kappa B activation which appears as an essential transcription factor for reperfusion-induced subacute endothelial activation. Both, acute and subacute endothelial activation seem to contribute to the final extent of leukocyte-dependent reperfusion injury and successive treatment of both appears to be a promising therapeutic strategy for postischemic myocardial inflammation and its detrimental effects.
Resistance to anti-CD19/CD3 BiTE in acute lymphoblastic leukemia may be mediated by disrupted CD19 membrane trafficking (2016)

The CD19 antigen is a promising target for immunotherapy of acute lymphoblastic leukemia (ALL), but CD19<sup>-</sup> relapses remain a major challenge in about 10% to 20% of patients. Here, we analyzed 4 CD19<sup>-</sup> ALL relapses after treatment with the CD19/CD3 bispecific T-cell engager (BiTE) blinatumomab. Three were on-drug relapses, with the CD19<sup>-</sup> escape variant first detected after only 2 treatment courses. In 1 patient, the CD19<sup>-</sup> clone appeared as a late relapse 19 months after completion of blinatumomab treatment. All 4 cases showed a cellular phenotype identical to the primary diagnosis except for CD19 negativity. This argued strongly in favor of an isolated molecular event and against a common lymphoid CD19<sup>-</sup> progenitor cell or myeloid lineage shift driving resistance. A thorough molecular workup of 1 of the cases with early relapse confirmed this hypothesis by revealing a disrupted CD19 membrane export in the post-endoplasmic reticulum compartment as molecular basis for blinatumomab resistance.
Gold nanorods induce early embryonic developmental delay and lethality in zebrafish (Danio rerio) (2017)

Due to their unique electronic and optical features, gold nanoparticles (AuNP) have received a great deal of attention for application in different fields such as catalysis, electronics, and biomedicine. The large-volume manufacturing predicted for future decades and the inevitable release of these substances into the environment necessitated an assessment of potential adverse human and ecological risks due to exposure to AuNP. Accordingly, this study aimed to examine the acute and developmental toxicity attributed to a commercial suspension of Au nanorods stabilized with cetyltrimethylammonium bromide (CTAB-AuNR) using early embryonic stages of zebrafish (Danio rerio), a well-established model in ecotoxicology. Zebrafish embryos were exposed to CTAB-AuNR (0-150 µg/L) to determine for developmental assessment until 96 hr post fertilization (hpf) and lethality. Uptake of CTAB-AuNR by embryos and nanoparticles potential to induce DNA damage was also measured at 48 and 96 hpf. Analysis of the concentration-response curves with cumulative mortality at 96 hpf revealed a median lethal concentration (LC<sub>50,96h</sub>) of 110.2 μg/L. At sublethal concentrations, CTAB-AuNR suspensions were found to produce developmental abnormalities such as tail deformities, pericardial edema, decreased body length, and delayed eye, head, and tail elongation development. Further, less than 1% of the initial concentration of CTAB-AuNR present in the exposure media was internalized by zebrafish embryos prior to (48 hpf) and after hatching (96 hpf). In addition, no marked DNA damage was detected in embryos after exposure to CTAB-AuNR. Overall, CTAB-AuNR suspensions produced lethal and sublethal effects on zebrafish embryos with possible repercussions in fitness of adult stages. However, these results foresee a low risk for fish since the observed effects occurred at concentrations above the levels expected to find in the aquatic environment.