gebhart/patrepeval huggingface dataset:
Combined Transplantation of Free Tissues (1987)

Combined transplantation of free tissues is a new microsurgical technique by which, with only one set of vessels supplying blood, two or more free tissues can be transplanted simultaneously. Very large soft-tissue defects that are not amenable to conventional transplantation, or defects of two or more tissues, either similar or different in nature, can be repaired in a one-stage operation. It is accomplished by vascular combination; i.e., by means of anastomosing the corresponding vessels of their pedicle, the free tissues to be transplanted are reconstituted into an assembly with only one common vascular pedicle which is then rejoined to the vessels selected to supply blood to the grafts in the recipient site. From December of 1983 to July of 1985, the author has performed 17 combined free-tissue transplantations of seven different clinical types for microsurgical repair and reconstruction of extremities. All the transplanted parts survived, and the extremities regained very good function. Seven patients are reported individually in the paper, each representing a definite clinical type. The concepts and operative technique introduced and the indications and advantages of the newly designed procedure are discussed.
Approach for Process Control in Additive Manufacturing Through Layer-Wise Analysis with 3-Dimensional Pointcloud Information (2018)

This work presents a suitable solution for capturing process data of an additive manufacturing process. Process control is necessary to increase the productivity and acceptance for these manufacturing techniques. Wrong adjusted parameters of an additive manufacturing process may cause in inaccurate manufacturing results and therefore the potential of additive manufacturing methods is underestimated. This approach uses a modified Fused Filament Fabrication system with integrated image sensors. The stereoscopic camera system captures 3d information about the object after every finished manufactured layers and the originated pointcloud is compared with the previously generated path planning, which is called G-code. The path planning is the result of the slicing process, which is absolutely necessary for every additive manufacturing process, and describes the movements for the additive manufacturing machine. The G-code is used in this approach for a reconstruction of the complete object layer by layer. The virtual reconstructed object represents the ideal manufacturing form and provides a comparing with the captured 3d information. Challenges are the G-code interpreting and the transformation of the Cartesian coordinate systems to a reference system. For this purpose a special transformation target is developed and a reference measurement system is used for evaluation.
Analysis of pulmonary features and treatment approaches in the COPA syndrome (2018)

The COPA syndrome is a monogenic, autoimmune lung and joint disorder first identified in 2015. This study sought to define the main pulmonary features of the COPA syndrome in an international cohort of patients, analyse patient responses to treatment and highlight when genetic testing should be considered. We established a cohort of subjects (N=14) with COPA syndrome seen at multiple centres including the University of California, San Francisco, CA, USA. All subjects had one of the previously established mutations in the <i>COPA</i> gene, and had clinically apparent lung disease and arthritis. We analysed cohort characteristics using descriptive statistics. All subjects manifested symptoms before the age of 12 years, had a family history of disease, and developed diffuse parenchymal lung disease and arthritis. 50% had diffuse alveolar haemorrhage. The most common pulmonary findings included cysts on chest computed tomography and evidence of follicular bronchiolitis on lung biopsy. All subjects were positive for anti-neutrophil cytoplasmic antibody, anti-nuclear antibody or both and 71% of subjects had rheumatoid factor positivity. All subjects received immunosuppressive therapy. COPA syndrome is an autoimmune disorder defined by diffuse parenchymal lung disease and arthritis. We analysed an international cohort of subjects with genetically confirmed COPA syndrome and found that common pulmonary features included cysts, follicular bronchiolitis and diffuse alveolar haemorrhage. Common extrapulmonary features included early age of onset, family history of disease, autoantibody positivity and arthritis. Longitudinal data demonstrated improvement on chest radiology but an overall decline in pulmonary function despite chronic treatment.
RESONANT M/NEMS PIEZORESISTORS FOR NARROW-BAND ELECTRONIC AMPLIFICATION (2014)

This work demonstrates amplification of electronic signals using a bare silicon electromechanical resonant micro-device. The structure consists of a narrow piezoresistor connecting two plates that can vibrate in an in-plane resonant mode. It is shown that vibration amplitude amplification by a combination of mechanical quality factor and thermal-piezoresistive "energy pumping" can turn the relatively weak piezoresistivity of silicon into a viable amplification mechanism. The energy pump is a result of interactions between electro-thermal forces in the piezoresistor and its piezoresistivity leading to a negative electrical equivalent resistance for the device (i.e. an active element). Tunable voltage gains up to 16dB for a 50 load have been demonstrated at 4.8MHz. The thermal-piezoresistive coupling also significantly enhances the effective quality factor (Q) of the resonator showing Q of up to 204,000 for a structure with intrinsic mechanical Q of less than 15,000 in air. Such narrow band amplifiers can potentially be used as channel selective low-noise amplifiers in wireless communications eliminating the need for multiple off-chip filtering steps.
Draft Genome Sequence of Cyanobacterium sp. Strain HL-69, Isolated from a Benthic Microbial Mat from a Magnesium Sulfate-Dominated Hypersaline Lake (2018)

The complete genome sequence of <i>Cyanobacterium</i> sp. strain HL-69 consists of 3,155,247 bp and contains 2,897 predicted genes comprising a chromosome and two plasmids. The genome is consistent with a halophilic nondiazotrophic phototrophic lifestyle, and this organism is able to synthesize most B vitamins and produces several secondary metabolites.
A numerical study of rapid heating for high temperature radio frequency hyperthermia. (1994)

Hyperthermia is a promising adjuvant cancer treatment modality. However, unresolved engineering problems with the production and regulation of temperature distributions within tissues in vivo have frustrated repeated efforts to implement clinical hyperthermia protocols. A major technical problem with hyperthermia production in vivo is the cooling effect caused by circulating blood in larger vessels. Larger blood vessels, when located in heated tumors, can prevent achievement of sufficiently high temperatures, resulting in loss of therapeutic effect. One possible way of circumventing this problem is the delivery of a critical heat dose during a short-term, high-temperature treatment episode to minimize cooling from blood flow. We investigated the concept of such rapid, high-temperature heating of tissue in a two-dimensional finite element numerical model. The model demonstrates the feasibility of interstitial radiofrequency delivery of a therapeutic heat dose, equivalent to 30 min at 43 degrees C, to a 1 cm3 tumor during a 60-s period. The model assumes circulation of cooling fluid through hollow electrodes. A post processor has been designed to display a 3-D image of the temperature distribution, electric field, and thermal dose delivered to a unit volume within the heated tissue.
The Natural History of Erectile Dysfunction After Prostatic Radiotherapy: A Systematic Review and Meta-Analysis (2017)

Definitions and measurements of ED after RT vary considerably in published series and could account for variability in the prevalence of reported ED. Loss to follow-up in studies could bias the results to overestimate ED. Gaither TW, Awad MA, Osterberg EC, et al. The Natural History of Erectile Dysfunction After Prostatic Radiotherapy: A Systematic Review and Meta-Analysis. J Sex Med 2017;14:1071-1078.
Triggering the apoptosis of targeted human renal cancer cells by the vibration of anisotropic magnetic particles attached to the cells membrane (2016)

International audience
Introduction of new traits into cotton through genetic engineering. The example of insect resistance (1996)

La résistance aux insectes est un objectif majeur pour l'amélioration variétale du cotonnier, la lutte mettant en jeu 30 % du marché mondial des insecticides chimiques. La première démarche a consisté à introduire et à faire exprimer dans la plante des gènes issus de Bacillus thuringiensis, bactérie productrice de toxine entomopathogénique. Les études sur l'expression dans le génome sont en cours. La deuxième priorité consiste dans la stratégie contre l'apparition de résistance à la toxine chez l'insecte ; d'où le recours préconisé à l'emploi de plusieurs gènes de résistance, associés à un gène codant pour des inhibiteurs de protéases. Ce programme de recherche est conduit par une entente CIRAD-INRA
Inorganic Syntheses. Volume VI. (1961)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInorganic Syntheses. Volume VI.Russell S. DragoCite this: J. Am. Chem. Soc. 1961, 83, 9, 2216–2217Publication Date (Print):May 1, 1961Publication History Published online1 May 2002Published inissue 1 May 1961https://pubs.acs.org/doi/10.1021/ja01470a059https://doi.org/10.1021/ja01470a059research-articleACS PublicationsRequest reuse permissionsArticle Views69Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Structure and Motion of Surfaces (1999)

For smooth curved surfaces the dominant image feature is the apparent contour or outline. This is the projection of the contour generator — the locus of points on the surface which separate visible and occluded parts. The contour generator is dependent of the local surface geometry and the viewpoint. Each viewpoint will generate a different contour generator. This paper addresses the problem of recovering the 3D shape and motion of curves and surfaces from image sequences of apparent contours.
A pH-/thermo-responsive hydrogel formed from N,N′-dibenzoyl-l-cystine: properties, self-assembly structure and release behavior of SA (2019)

In this study, we report a pH-/thermo-responsive hydrogel formed by <i>N</i>,<i>N</i>'-dibenzoyl-l-cystine (DBC). It is difficult to dissolve DBC in water even on heating, and it exhibits no gelation ability. Interestingly, DBC is readily soluble in NaOH solution at room temperature and the self-assembled hydrogels are obtained by adjusting the basic DBC aqueous solution with HCl to achieve a given pH value (<3.5). When NaOH is added to the hydrogel (pH > 9.4), it becomes a sol again. This small-molecule hydrogel is characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, rheological measurement and differential scanning calorimetry. The results indicate that the DBC hydrogel exhibits excellent mechanical properties, thermo-reversibility, and pH-responsive properties. Fortunately, the single crystal of DBC is obtained by volatilizing its acid aqueous solution. It crystallizes in the monoclinic space group <i>P</i>2<sub>1</sub> (<i>Z</i> = 2) with lattice parameters <i>a</i> = 10.8180 (11) Å, <i>b</i> = 9.0405 (9) Å, <i>c</i> = 10.9871 (11) Å and <i>β</i> = 90.798 (3)°. By comparing the X-ray diffraction result of the DBC single crystal with that of its xerogel, the self-assembled structure of DBC in hydrogel has been ascertained. The gelators are self-assembled <i>via</i> strong intermolecular hydrogen bonds linking neighboring amide and carboxyl groups, π-π stacking interactions for aromatic rings, and hydrogen bonds between water molecules. In addition, the release behavior of salicylic acid (SA) molecules from the DBC gel is also investigated taking into account the DBC concentration, phosphate buffer solution (PBS) pH and SA concentration. When the concentrations of DBC and SA are 3.0 g L<sup>-1</sup> and 200 mg L<sup>-1</sup>, respectively, the release ratio in PBS (pH = 4.0) reaches 58.02%. The diffusion-controlled mechanism is in accordance with Fickian diffusion control within the given time range.
Alterations in gene expression profiles during prostate cancer progression: functional correlations to tumorigenicity and down-regulation of selenoprotein-P in mouse and human tumors. (2002)

To identify molecular changes that occur during prostate tumor progression, we have characterized a series of prostate cancer cell lines isolated at different stages of tumorigenesis from C3(1)/Tag transgenic mice. Cell lines derived from low- and high-grade prostatic intraepithelial neoplasia, invasive carcinoma, and a lung metastasis exhibited significant differences in cell growth, tumorigenicity, invasiveness, and angiogenesis. cDNA microarray analysis of 8700 features revealed correlations between the tumorigenicity of the C3(1)/Tag-Pr cells and changes in the expression levels of genes regulating cell growth, angiogenesis, and invasion. Many changes observed in transcriptional regulation in this in vitro system are similar to those reported for human prostate cancer, as well as other types of human tumors. This analysis of expression patterns has also identified novel genes that may be involved in mechanisms of prostate oncogenesis or serve as potential biomarkers or therapeutic targets for prostate cancer. Examples include the L1-cell adhesion molecule, metastasis-associated gene (MTA-2), Rab-25, tumor-associated signal transducer-2 (Trop-2), and Selenoprotein-P, a gene that binds selenium and prevents oxidative stress. Many genes identified in the Pr-cell line model have been shown to be altered in human prostate cancer. The comprehensive microarray data provides a rational basis for using this model system for studies where alterations of specific genes or pathways are of particular interest. Quantitative real-time reverse transcription-PCR for Selenoprotein-P demonstrated a similar down-regulation of the transcript of this gene in a subset of human prostate tumors, mouse tumors, and prostate carcinoma cell lines. This work demonstrates that expression profiling in animal models may lead to the identification of novel genes involved in human prostate cancer biology.
Supplementary Table 1 from A Mutant Collagen XIII Alters Intestinal Expression of Immune Response Genes and Predisposes Transgenic Mice to Develop B-Cell Lymphomas (2023)

Supplementary Table 1 from A Mutant Collagen XIII Alters Intestinal Expression of Immune Response Genes and Predisposes Transgenic Mice to Develop B-Cell Lymphomas
Nonlinearities in a Single Nut, Preloaded, Precision Ball Screw (1997)

Abstract The nonlinear performance of a single-nut, preloaded ball screw actuator is analyzed in this paper. The study identifies the source of nonlinear torque in the ball screw and subsequently maps that torque into the nonlinear displacement response due to windup in the shaft. The study is complemented with an experimental verification using a small angle rotation fixture (ARC) to input very small amplitude angular displacements to the screw while measuring induced torque and displacements. The experimental results are obtained from a Precision Linear Optimization Testbed (PLOT) which was developed to study the ability of different actuator systems to provide long range motion with nanometer accuracy. The analysis is conducted for the case of no axial loading. The study shows that the nonlinearities in the ball screw originate in the rolling friction between the balls and the races which induces torque in the nut and subsequently windup in the shaft. It also shows that the torque can be deduced from a relationship of the torque between a ball spinning in a race.
Design and characterization of thick InxGa1-xAs metamorphic buffer layers grown by hydride vapor phase epitaxy (2014)

Thick InxGa1-xAs metamorphic buffer layers (MBLs) grown by hydride vapor phase epitaxy (HVPE) were studied. Relationships between MBL properties and growth parameters such as grading rate, cap layer thickness, final xInAs, and deposition temperature (TD) were explored. The MBLs were characterized by measurement of in-plane residual strain (???), surface etch pit density (EPD), and surface roughness. Capping layer thickness had a strong effect on strain relaxation, with thickly capped samples exhibiting the lowest ???. EPD was higher in samples with thicker caps, reflecting their increased relaxation through dislocation generation. ??? and EPD were weakly affected by the grading rate, making capping layer thickness the primary structural parameter which controls these properties. MBLs graded in discrete steps had similar properties to MBLs with continuous grading. In samples with identical thickness and 10-step grading style, ??? increased almost linearly with final xInAs, while total relaxation stayed relatively constant. Relaxation as a function of xInAs?could be described by an equilibrium model in which dislocation nucleation is impeded by the energy of the existing dislocation array. EPD was constant from xInAs?= 0 to 0.24 then increased exponentially, which is related to the increased dislocation interaction and blocking seen at higher dislocation densities. RMS roughness increased with xInAs?above a certain strain rate (0.15%/?m); samples grown below this level possessed large surface hillocks and high roughness values. The elimination of hillocks at higher values of xInAs?is attributed to increased density of surface steps and is related to the out-of-plane component of the burgers vector of the dominant type of 60? dislocation. TD?did not affect ??? for samples with a given xInAs. EPD tended to increase with TD, indicating dislocation glide likely is impeded at higher temperatures.
Distinct differences in gut microbial composition and functional potential from lean to morbidly obese subjects (2020)

Based on the faecal microbiota composition, we were able to separate subjects with and without obesity. In addition, we found strong associations between gut microbial amino acid metabolism and specific microbial species in relation to clinical features of obesity.
Radiation curing: Science and technology (1992)

Radiation Curing S.P. Pappas. Inorganic and Organometallic Photoinitiators D.B. Yang, C. Kutal. Calorimetric Analysis of Photopolymerization C.E. Hoyle. Kinetic Analysis and Performance of UV Curable Coatings C. Decker. Photopolymerizable Silicone Monomers, Oligomers, and Resins A.F. Jacobine, S.T. Nakos. Radiation Induced Cationic Curing of Vinyl Ethers S.C. Lapin. Radiation Curable Coatings with Emphasis on the Graphic Arts H.R. Ragin. Radiation Curing of Printing Inks A.J. Bean. Radiation Curable Adhesives J.G. Woods. Photopolymers B.N. Monroe. Index.
Notes: Reactions of Zirconium Tetrachloride with Acetone (1959)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNotes: Reactions of Zirconium Tetrachloride with AcetoneP Joseph and W BlumenthalCite this: J. Org. Chem. 1959, 24, 9, 1371–1372Publication Date (Print):September 1, 1959Publication History Published online11 July 2003Published inissue 1 September 1959https://pubs.acs.org/doi/10.1021/jo01091a626https://doi.org/10.1021/jo01091a626research-articleACS PublicationsRequest reuse permissionsArticle Views160Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
O48 Novel interactions between bacterial strains and mucosal immune profiles after FMT for UC: STOP-colitis results (2022)

<h3>Background</h3> Faecal microbiota transplantation (FMT) demonstrates therapeutic potential in ulcerative colitis (UC). Through a prospective, open-label randomised trial (STOP-Colitis pilot) we examined mechanistic insights associated with clinical response to FMT in UC. <h3>Methods</h3> Thirty adult participants with active UC were randomised to either colonic (n=14) or nasogastric (n=16) route of administration of 8 FMT infusions over 8 weeks. Each patient was matched to an FMT donor. Changes in faecal microbial diversity and composition before/after FMT were analysed with shotgun metagenomics. Stool metabolomics analysis and mucosal immune cell phenotyping was performed. Correlation was evaluated with Kendall’s Tau coefficient. <h3>Results</h3> Eleven of the 20 patients completing the study achieved a clinical response to FMT. Response to FMT was associated with an increase in alpha diversity (P&lt;0.005) and lower faecal calprotectin compared to non-responders. A negative association between calprotectin levels and alpha diversity was observed (P&lt;0.005). Operational taxonomic units belonging to Clostridia deriving from the <i>Christensenellaceae</i> and <i>Lachnospiracae</i> families correlated with both reduced calprotectin and had high engraftment frequency (FDR adjusted P&lt;0.10). In a cohort of patients with mucosal immune cell phenotyping, faecal metagenomic analysis revealed that multiple species belonging to <i>Lachnospiraceae</i>, <i>Butyricicoccaceae</i> and <i>Oscillospiraceae</i> families correlated positively with gut homing Tregs and negatively with Th17 cells (FDR adjusted P&lt;0.10). Th17 cells positively correlated with flagellar adhesion and virulence pathways. Stool metabolomics analysis revealed a significant increase in butyrate following FMT however this did not correlate with response. <h3>Conclusion</h3> We demonstrate significant correlations linking response to FMT and mucosal immunoregulatory shifts with changes in gut microbial diversity and key microbial species (short chain fatty acid producers) in patients with UC.