gebhart/patrepeval huggingface dataset:
The timely technical consulting for prevention work-related musculoskeletal disorders (2013)

Objective: This study is aimed at introduce the work-related musculoskeletal disorders(WMSDs) prevention activity in KOREA, focused on the timely technical consulting for WMSDs. Method: This activity is fist started from 2012, we visited the company in 2 months that occurred WMSDs. We consulted the preventive measures on the process that occurred WMSDs, and educated the employees about correct posture during work. Also, we visited again if the company recurrenced WMSDs. Results: We consulted 2,074 companies(under 300 workers) last year. The risk factors consisted of 59.3% accidental lumbar pain, 21.8% burdened work, 17.4% non-accidental and occupation related lumbar pain and 1.5% carpal tunnel syndrome and business consisted of service industry(46.2%) and manufacturing industry(41.0%). Examining MSDs in detail indicated that the majority of patients were male(80.4%), have less than 6 month of work experience(30.7%) and have worked for companies with less than 5 workers(28.9%). Only 20 of companies that we visited recurrenced a WMSDs in same year. Conclusion: WMSDs have increased steadily in KOREA and occupied 70% of occupational diseases. The timely technical consulting is very effective activity to prevent WMSDs. And it must to be expanded to actively prevent WMSDs.
Reply to F. Campodonico et al (2010)

The view that sextant biopsies were insufficient to evaluate prostate cancer emerged in the mid-1990s, around the time that our prospective trial was initiated. This became widely accepted by 2000 to 2003. Our group thought from the beginning that as thorough an assessment as possible of the extent of pathologic disease should be performed, and adopted an extended biopsy strategy in the surveillance patients early on. In many patients whose initial biopsy was performed elsewhere, sextant biopsies were performed. These patients had extended biopsies on the 12-month biopsy in most cases. We adopted the formal Vienna nomogram when it became available, and used this term to describe our technique. Campodonico et al are correct that, strictly speaking, the extended biopsies performed between 1995 and 2003 were not performed according to the Vienna nomogram. We agree that taking more cores depending on age and prostate volume enhances the accuracy of prostate biopsy. Even with the Vienna nomogram approach, however, some patients with large anterior cancers are missed. Currently, we specifically target this area on repeat biopsy. Nonetheless, despite the inaccuracies of biopsy and prostate-specific antigen kinetics, the prostate cancer mortality in this population remains reassuringly low. Laurence Klotz and Andrew Loblaw Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
New imaging strategies for patient selection for thrombolytic and neuroprotective therapies (2001)

Ischemic stroke trials have traditionally sought to limit the range of disease studied according to several dimensions based on clinical examination and CT scan results. It has been proposed that the optimal sample for stroke trials would include a positive imaging diagnosis of a pathology rationally linked to the drug's mechanisms of action and that this would improve the likelihood of positive results. This principle has been supported by the results of the Prolyse in Acute Cerebral Thromoembolism II (PROACT II) study. Whereas trials of iv thrombolysis between 3 and 6 hours after symptom onset in a general sample of patients were not positive, selection of a subgroup by angiography was an effective strategy in this time period for PROACT II. This study contradicted the hypothesis that treatment of stroke beyond 3 hours would not be successful. MRI with diffusion and perfusion has been an appealing imaging modality because it provides pretreatment angiography, perfusion, and lesion volume information during a brief, non-invasive assessment. Current literature supports the validity of MRI as a marker for clinical severity and clinical improvement. The diffusion-perfusion mismatch, the MRI marker for the ischemic penumbra, is a very strong predictor of lesion volume growth. Several acute trials in progress use a positive imaging diagnosis for the basis of selection. As the field of stroke clinical trials examines opportunities for improving trial design, positive imaging diagnoses in patient selection are likely to assume an increasingly useful role.
Absolute linearity measurements on HgCdTe detectors in the infrared region (2004)

The nonlinearity characteristics of photoconductive and photovoltaic HgCdTe detectors were experimentally investigated in the infrared wavelength region by use of the National Physical Laboratory detector linearity measurement facility. The nonlinearity of photoconductive HgCdTe detectors was shown to be a function of irradiance rather than the total radiant power incident on the detector. Photoconductive HgCdTe detectors supplied by different vendors were shown to have similar linearity characteristics for wavelengths around 10 microm. However, the nonlinearity of response of a photovoltaic HgCdTe detector was shown to be significantly lower than the corresponding value for photoconductive HgCdTe detectors at the same wavelength.
Maintaining outstanding outcomes using response- and biology-based therapy for intermediate-risk neuroblastoma: A report from the Children’s Oncology Group study ANBL0531. (2014)

10006 Background: This Phase III prospective reduction of therapy study used tumor biologic features to determine the minimal treatment needed to achieve excellent outcomes in patients with intermediate risk (IR) neuroblastoma (NB). Methods: Between 10/8/2007 and 6/30/2011, 464 patients enrolled; 401 had evaluable IR NB. Eligibility included newly diagnosed single copy MYCN NB and: age <12 years with stage 2A/B <50% resected or stage 3 with favorable biology, age <365 days with stage 3 or 4, and all patients <365 days with stage 4S, including those too ill to undergo biopsy. Toddlers age 365-<547 days with favorable biology stage 4 NB and age 365-<547 days with stage 3 and unfavorable histology (UH) received isotretinoin in addition to chemotherapy. Risk-stratification and therapy assignment utilized age, INSS stage, INPC, MYCN, and tumor ploidy. Therapy reduction was prescribed for tumors without loss of heterozygosity (LOH) at 1p36 and/or 11q23. Therapy included 2-8 courses of chemotherapy +/- surgery. Treatment endpoint for localized favorable biology tumors was partial response. Results: The 3-year EFS/OS for all IR patients was 83±3%/95±2%. The presence of 1pLOH and/or unbalanced 11qLOH was detected in 18% of IR tumors. To date, there were no deaths due to disease in patients with localized favorable biology tumors. Among 124 stage 4 patients <365 days, 3-year EFS/OS for favorable biology (n=60) was 90±5%/95±4%; for unfavorable biology (diploid and/or UH, irrespective of LOH, n=24) was 63±16%/76±13% and 65±14%/95±7% for tumors with LOH (n=20). Among 9 stage 4 toddlers there were 3 relapses; 3-year OS 100%. Eight of 46 patients with stage 4S NB died; 5 were due to complications of hepatomegaly. Conclusions: Further reduction of therapy and prospective refinement of treatment using genomic stratification achieved excellent survival in the majority of IR NB patients. Some unfavorable biology IR tumors may benefit from novel treatment strategies. Clinical trial information: NCT00499616.
[Anti-atherogenic drugs]. (1998)

Rupture of an instable plaque, characterized by a large lipid-rich central core, inflammatory cells, and a thin fibrous cap, causes sudden thrombus formation and acute coronary syndromes (ACS). Lipid lowering therapy by HMG-CoA reductase inhibitors leads to reduction of cardiovascular complications, but has very small effect on the degree of stenosis of ACS. Oxidizing metabolites generated at the site of coronary angioplasty can induce chain reactions that may lead to restenosis. Probucol improves the restenosis rate after coronary angioplasty if given before PTCA (percutaneous transluminal coronary angioplasty). These results will provide a better understanding of drug action, help explain certain drug interactions, and facilitate the choice of a drug for ACS.
Laminitis in ponies is a diabetic‐like state (2007)

Equine pasture-associated laminitis is a devastating disease manifested in the hoof and associated with obesity, dietary carbohydrate and insulin resistance, risk-factors which parallel human metabolic syndromes. In this study, 5 laminitic ponies were evaluated for insulin sensitivity (SI) and insulin response to glucose (AIRg) using the minimal model of glucose and insulin dynamics adapted for equines from its original application in diabetic humans. Ponies were kept on pasture and tested in late April on the 1st or 2nd day of clinical laminitis. On the morning of the test ponies were brought into stalls, jugular catheters were inserted, and an insulin-modified frequently sampled glucose tolerance test was conducted over 4 hours. Three of the 5 ponies showed no effect of insulin on glucose disposal rate (effective SI = 0). These ponies had basal insulin of 114, 353 and 549 mIU/L (normal insulin <40), however all 3 demonstrated low AIRg (<100 mIU/L per min) indicating an incapacity to increase circulating insulin in response to a glucose challenge. Two of these ponies were hyperglycemic (basal glucose 143 and 162 mg/dL) and all 3 were hyperglycemic at the end of the test. Extreme insulin resistance may be associated with clinical laminitis in ponies, contributing to a diabetic-like state in which the pancreas is unresponsive to changes in circulating glucose despite remarkable persistent circulating insulin concentrations.
Intermolecular pyrene excimer formation in zeolites. Decay parameters and ground-state association (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIntermolecular pyrene excimer formation in zeolites. Decay parameters and ground-state associationSteven L. Suib and Athanasios KostapapasCite this: J. Am. Chem. Soc. 1984, 106, 25, 7705–7710Publication Date (Print):December 1, 1984Publication History Published online1 May 2002Published inissue 1 December 1984https://pubs.acs.org/doi/10.1021/ja00337a010https://doi.org/10.1021/ja00337a010research-articleACS PublicationsRequest reuse permissionsArticle Views206Altmetric-Citations43LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Novel Multi-Time Scale Deep Learning Algorithm for Solar Irradiance Forecasting (2021)

Solar irradiance forecasting is an inevitable and most significant process in grid-connected photovoltaic systems. Solar power is highly non-linear, and thus to manage the grid operation efficiently, with irradiance forecasting for various timescales, such as an hour ahead, a day ahead, and a week ahead, strategies are developed and analysed in this article. However, the single time scale model can perform better for that specific time scale but cannot be employed for other time scale forecasting. Moreover, the data consideration for single time scale forecasting is limited. In this work, a multi-time scale model for solar irradiance forecasting is proposed based on the multi-task learning algorithm. An effective resource sharing scheme between each task is presented. The proposed multi-task learning algorithm is implemented with a long short-term memory (LSTM) neural network model and the performance is investigated for various time scale forecasting. The hyperparameter estimation of the proposed LSTM model is made by a hybrid chicken swarm optimizer based on combining the best features of both the chicken swarm optimization algorithm (CSO) and grey wolf optimization (GWO) algorithm. The proposed model is validated, comparing existing methodologies for single timescale forecasting, and the proposed strategy demonstrated highly consistent performance for all time scale forecasting with improved metric results.
OP28.10: Cost‐effectiveness of testing amniotic fluid for alpha‐fetoprotein and acetocholinesterase versus detailed ultrasound (2012)

Evaluate the cost-benefit of measuring amniotic fluid alpha-fetoprotein (AFAFP) and acetocholinesterase (ACHE) for the detection of open neural tube (NTD) or ventral wall defects (VWD). A ten year retrospective chart review was performed on all patients undergoing amniocentesis by Maternal Fetal Medicine specialists at our center (n = 6, 248). AFAFP was routinely obtained. Cases with an elevated AFAFP were compared to those with values in the normal range. Ultrasounds were performed by certified obstetrical sonographers and MFM specialists. Archived records were reviewed to determine indications for amniocentesis and maternal serum AFP values as well as the incidence of NTD or VWD. All cases with undetected ultrasound abnormalities and elevated AFAFP or positive ACHE were reevaluated and follow up obtained to determine if any abnormalities went undetected. A cost-benefit ratio was then performed. 6,248 women underwent amniocentesis between January 2002 and December 2012. Indications for amniocentesis included advanced maternal age, maternal anxiety, abnormal serum screening and abnormal ultrasound findings. 83 patients had an elevated AFAFP with or without a positive ACHE. Among these 83 cases, 13 had ultrasound evidence for NTD and 5 for VWD. The positive predictive value of initial high resolution ultrasound was 100% in detecting NTD and VWD. Using AFAFP alone detected 22% of defects and including ACHE increased the rate to 77%. At a cost of $76 for AFAFP/sample, the total expenditure for AFAFP in our sample set was $474,848. For the 83 cases with elevated AFAFP, additional testing for ACHE ($114/sample) was performed for an added cost of $9462, leading to a total cost of $484,310. On analysis, the AFAFP and ACHE levels did not improve our ultrasound detection of NTDs or VWDs. AFAFP and ACHE testing is not a cost effective approach when compared to the diagnostic accuracy of high resolution ultrasound for the detection of NTD and/or VWD and did not influence patient care or management.
Two-way TCP traffic over rate controlled channels: effects and analysis (1998)

We study the performance of bidirectional TCP/IP connections over a network that uses rate-based flow and congestion control. An example of such a network is an asynchronous transfer mode (ATM) network using the available bit rate (ABR) service. The sharing of a common buffer by TCP packets and acknowledgment (acks) has been known to result in an effect called ack compression, where acks of a connection arrive at the source bunched together, resulting in unfairness and degraded throughput. It has been the expectation that maintaining a smooth flow of data using rate-based flow control would mitigate, if not eliminate, the various forms of burstiness experienced with the TCP window flow control. However, we show that the problem of TCP ack compression appears even while operating over a rate-controlled channel. The degradation in throughput due to bidirectional traffic can be significant. For example, even in the simple case of symmetrical connections with adequate window sizes, the throughput of each connection is only 66.67% of that under one-way traffic. By analyzing the periodic bursty behavior of the source IP queue, we derive estimates for the maximum queue size and arrive at a simple predictor for the degraded throughput, for relatively general situations. We validate our analysis using simulation on an ATM network using the explicit rate option of the ABR service. The analysis predicts the behavior of the queue and the throughput degradation in simple configurations and in more general situations.
Lightweight Directory Access Protocol (LDAP): Authentication Methods and Security Mechanisms (2006)

This document describes authentication methods and security mechanisms of the Lightweight Directory Access Protocol (LDAP). This document details establishment of Transport Layer Security (TLS) using the StartTLS operation. This document details the simple Bind authentication method including anonymous, unauthenticated, and name/password mechanisms and the Simple Authentication and Security Layer (SASL) Bind authentication method including the EXTERNAL mechanism. This document discusses various authentication and authorization states through which a session to an LDAP server may pass and the actions that trigger these state changes.
PERFORIN AND GRANZYME B GENE-EXPRESSING CELLS IN BRONCHOALVEOLAR LAVAGE FLUIDS FROM LUNG ALLOGRAFT RECIPIENTS DISPLAYING CYTOMEGALOVIRUS PNEUMONITIS (1994)

Humbert, Marc; Magnan, Antoine; Ledurie, Francois Le Roy; Dartevelle, Philippe; Simonneau, Gérald; Duroux, Pierre; Galanaud, Pierre; Emilie, Dominique Author Information
Systems Biology and Personalized Medicine (2012)

Human diseases have historically been classified on the basis of their end-organ manifestations, using a traditional clinicopathological approach dating to the 19th century. With the advent of rigorous molecular methodologies at the end of the 20th century, many specific disease determinants were identified and more targeted therapeutic strategies developed. Although the conventional reductionist approach underlying these strategies for understanding disease served us well in the pregenomic era, it hampers our understanding of the complex molecular networks within which disease develops that are increasingly manifest in the current era. This article presents a novel, holistic method for classifying human diseases that can serve as a template for understanding disease pathobiology, prognosis, and treatment.
β-Oxidofunctionalized organolithium intermediates from ketones: a simple new access (1987)

Chloromethyl-lithium generated in situ, reacts at –78 °C with ketones (5) to afford, after lithiation with lithium naphthalenide, β-oxidoalkyl-lithium compounds (1), which on reaction with electrophiles (deuterium oxide, dimethyl disulphide, carbon dioxide, cyclohexanone, and allyl bromide) yield bifunctionalized compounds (6).
A 1-GHz logic circuit family with sense amplifiers (1999)

This paper describes a newly developed logic circuit family based on dual-rail bit lines and sense amplifiers that is used extensively in a 1.0-GHz, single-issue, 64-bit PowerPC integer processor, gigahertz unit test site (guTS). The family consists of an incrementor, a count-leading-zero, a rotator, and a read-only memory. Each macro consists of a leaf-cell array, dual-rail bit lines, a row of sense amplifiers, a control block, and peripheral circuits. A common read-out scheme sensing the differential voltage of dual-rail bit lines is used. The hardware was fabricated in a 0.25-/spl mu/m drawn channel length, six-metal-layer (Al) CMOS technology (1.8-V nominal VDD). Wafer testing was performed using a probe card. The macros were tested cycle by cycle by scanning the input data to the read/write address latches and data latches, and scanning the result out from the output receiving latches. Functional testing was performed on guTS macros at frequencies up to 1.0 GHz at 25/spl deg/C with nominal VDD (1.1 GHz for the ROM).
A multiplex droplet digital PCR assay for non-invasive prenatal testing of fetal aneuploidies (2019)

Higher multiplexing in droplet digital PCR (ddPCR) can simplify the detection process of ddPCR-based non-invasive prenatal testing (NIPT) and improve its reliability, making it a practical approach in clinical practice. However, a high level of multiplex ddPCR-based NIPT has rarely been reported. In this study, we developed a multiplex ddPCR assay using universal locked nucleic acid (LNA) probes to reliably identify fetal aneuploidies. We first performed statistical analysis based on the Poisson distribution to evaluate the required number of target DNA molecules and the total number of droplets for a ddPCR assay. Next, we designed two sets of primers and probes to quantify cfDNA from chromosomes 21 and 18 and then determined the disease status of a sample. Finally, we evaluated our multiplex ddPCR assay with 60 clinical plasma samples. All of the 60 clinical samples were correctly identified. The accessibility and cost-effectiveness of our multiplex ddPCR-based NIPT make it a competitive prenatal testing method in clinical use.
Marker-less tracking for AR: a learning-based approach (2002)

Estimating the pose of a camera (virtual or real) in which some augmentation takes place is one of the most important parts of an augmented reality (AR) system. The availability of powerful processors and fast frame grabbers has made the use of vision-based trackers commonplace due to their accuracy as well as flexibility and ease of use. Current vision-based trackers are based on tracking of markers. The use of markers increases robustness and reduces computational requirements. However, their use can be very complicated, as they require maintenance. Direct use of scene features for tracking, therefore, is desirable. To this end, we describe a general system that tracks the position and orientation of a camera observing a scene without visual markers. Our method is based on a two-stage process. In the first stage, a set of features is learned with the help of an external tracking system during use. The second stage uses these learned features for camera tracking when the system in the first stage decides that it is possible to do so. The system is very general so that it can employ any available feature tracking and pose estimation system for learning and tracking. We experimentally demonstrate the viability of the method in real-life examples.
Characterization of an Alternating-Current Plasma Source for Atomic Emission Spectroscopy (1991)

Results on the characterization of a helium alternating-current plasma (ACP) are presented. Spectroscopic techniques were utilized to obtain diagnostic measurements of the plasma. The characteristics studied include appearance, excitation temperature, ionization and electron temperature, electron number density, and interferences from other concomitants. Sample introduction was achieved with a glass frit nebulizer (GFN). Enhancement of the calcium response was observed while sodium was present in the plasma. Signal depression was noted when calcium and phosphate were simultaneously introduced into the ACP.