gebhart/patrepeval huggingface dataset:
BIOCOMPATIBILITY AND BIODEGRADABILITY OF ELECTROSPUN PHEA-PLA SCAFFOLDS: OUR PRELIMINARY EXPERIENCE IN A MURINE ANIMAL MODEL (2012)

We obtained a nano-fibrillar scaffold starting from a polymeric solution which, through electrospinning, gave a biodegradable material with optimal mechanical features and the capacity to allow cell adhesion. In this paper we report the in-vivo application on a murine animal model of two electrospun biodegradable materials, specifically designed to create tubular structures. In one case PHEA-PLA was co-spun with silk fibroin (Fibro-PHEAPLA) by a parallel electrospinning process to obtain a scaffold with two different polymeric fibers. In the other case, PHEA-PLA was mixed with polycaprolactone (PCLPHEA-PLA) to obtain a hybrid fibers scaffold. The in-vitro assay showed fibroblast colonization in both materials. The scaffolds were implanted in the dorsal fascial pouch of rats to evaluate their in-vivo biocompatibility and tissue integration. Histopathological findings showed that after implantation a neutrophilic reaction associated to colliquative necrosis was predominant, particularly for PCL-PHEA-PLA. Fibro-PCL-PHEA caused a non organized stromal reaction. Cell adhesion was confirmed at SEM scan. Both materials were totally absorbed after 40 days with an inflammatory reaction. This preliminary study showed that biocompatibility of the scaffolds needs further investigation. The capability of the materials to be functionalized could allow us to modulate the inflammatory host response.
Automatic Convolutional Neural Network Selection for Image Classification Using Genetic Algorithms (2018)

Deep neural networks such as Convolutional Neural Networks (CNNs) have achieved several significant milestones in visual data analytics. Benefited from transfer learning, many researchers use pre-trained CNN models to accelerate the training process. However, there is still uncertainty about the deep learning models, structures, and applications. For instance, the diversity of the datasets may affect the performance of each pre-trained model. Therefore, in this paper, we proposed a new approach based on genetic algorithms to select or regenerate the best pre-trained CNN models for different visual datasets. A new genetic encoding model is presented which denotes different pre-trained models in our population. During the evolutionary process, the optimal genetic code that represents the best model is selected, or new competitive individuals are generated using the genetic operations. The experimental results illustrate the effectiveness of the proposed framework which outperforms several existing approaches in visual data classification.
Coherent anti-Stokes Raman scattering diagnostics of combustion and other reactive media at ONERA (1985)

Coherent anti-Stokes Raman scattering (CARS) is well adapted to the measurement of temperatures and concentrations of molecules in reactive gaseous media. The general principles are given along with the major technical advantages and requirements. Characteristic applications are described in order to present state-of-the-art performance levels: measurement time, spatial resolution, detection sensitivity. Results are presented of instantaneous temperature measurements in combustion and in piston engines, measurements of rotational–vibrational populations of H2 in a magnetic multicusp discharge, and measurements of the vibrational excitation of the prompt H2 formed in H2CO dissociation.
Deploying virtual honeypots on virtual machine monitor (2008)

Xen is a virtual machine monitor that supports execution of multiple guest operating systems on the same computer hardware at the same time with unprecedented levels of performance and resource isolation. Honeypot is a decoy system, deployed throughout the network, which purposely built to attract and deceive computer intruders and malicious programs. In this paper, we review the combination of both, virtualization technologies of Xen and honeypot concept, in order to deploy and run virtual honeypot on top of virtual machine monitor.
Nanoscale metal oxide particles as chemical reagents. Intrinsic effects of particle size on hydroxyl content and on reactivity and acid/base properties of ultrafine magnesium oxide (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNanoscale metal oxide particles as chemical reagents. Intrinsic effects of particle size on hydroxyl content and on reactivity and acid/base properties of ultrafine magnesium oxideHidenobu Itoh, Suchada Utamapanya, Jane V. Stark, Kenneth J. Klabunde, and John R. SchlupCite this: Chem. Mater. 1993, 5, 1, 71–77Publication Date (Print):January 1, 1993Publication History Published online1 May 2002Published inissue 1 January 1993https://pubs.acs.org/doi/10.1021/cm00025a015https://doi.org/10.1021/cm00025a015research-articleACS PublicationsRequest reuse permissionsArticle Views731Altmetric-Citations117LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Evaluation of packet-by-packet downlink radio resource management schemes (2002)

The OFDM based terrestrial digital video broadcasting system (DVB-T) can be utilized for asymmetric Internet access with a downlink peak bit rate of 10-20Mbps. A narrow-band cellular communications system cam be used as uplink. This paper is a comparison of centralized dynamic radio resource management schemes for this downlink packet radio system. Spectrum efficiency in bit/s/Hz/transmitter, and fairly shared spectrum efficiency in bit/s/Hz/transmitter, are evaluated for a best-effort traffic snapshot model. The dynamic packet assignment (DPA) algorithm performs combined packet scheduling and rapid dynamic channel allocation. Even better performance is achieved by the dynamic single frequency networks (DSFN) scheme. It exploits the macro-diversity capability of OFDM modulation. The base station transmitters are dynamically divided into groups that send the same information at the same channel frequency simultaneously.
Cell Volume Regulation in the Nephron (1990)

Nearly every cell in the kidney can volume regulate in response to a hypertonic challenge. Some are able to respond immediately to hyperosmotic media by a RVI. Other cells require stimulation prior to exposure to hyperosmolarity to demonstrate RVI. An increase of intracellular osmolytes during RVI usually occurs by an increase of NaCl influx either via the activation of parallel Na(+)-H+ and Cl(-)-HCO3- exchangers, or Na(+)-K(+)-2Cl- cotransporters. Medullary and papillary cells use organic solutes as well to increase the intracellular concentration of osmolytes. In response to a hypotonic challenge, a RVD response has been demonstrated in the majority of the kidney cells. The efflux of solute during RVD is usually via K+ loss by activation of conductance pathways. Stretch-activated K+ channels and Ca2(+)-activated-K+ channels have been shown to be stimulated in cells exposed in hyposmotic solutions and could thus be involved in RVD. The accompanying anion loss is less well-defined but could be either Cl- or HCO3- in different segments of the nephron. In some cells, the reduction of intracellular solute content is via an efflux of organic osmolytes. Thus it appears that cells in all segments of the nephron volume regulate in response to osmotic stresses. This regulation may be an essential part of transepithelial transport since the cells have to survive transcellular fluxes of osmolytes. It may be particularly important in the kidney to control cell volume both in response to changes in osmolarity and transcellular fluxes of solute in order to maintain proper flow of fluid through the nephron.
Dynamic Effect of Heat Shock Pretreatment on Apoptotic Responses to TNF-α in Liver Cells (2009)

The heat shock (HS) response is a protective mechanism for cells to protect themselves against subsequent lethal stress. HS upregulated heat shock protein (HSP) expression reduced apoptosis following tumor necrosis factor-alpha (TNF-alpha) stimulation. However, vector-mediated overexpression of HSP70 failed to provide similar protection but rather sensitized cells to TNF-alpha induced apoptosis. This may be due to the fact that the kinetics of vector-mediated HSP overexpression is totally different from that of HSP upregulation by HS. We hypothesized that the response depends on the timing of TNF-alpha challenge relative to HSP expression dynamics after HS. Therefore, we investigated the correlation between the dynamic change of HSP expression and the levels of apoptosis induced by TNF-alpha after HS. Hepatoma cells were subjected to mild heat shock at 42 degrees C for 2 h followed by varied recovery times and then treated with TNF-alpha to induce apoptosis. The results from quantitative apoptosis assays using the TUNEL reaction reveal an optimal HS protection window centered around 5 h post-HS against TNF-alpha induced apoptosis. In addition, we found a window extending up to 2 h after HS where HS sensitized cells to TNF-alpha stress. Importantly, the correlation between apoptosis and HSP expression kinetics demonstrates that both high levels of HSPs and proper timing between HS and TNF-alpha stress were critical for optimal protection. Our study establishes a dynamic experimental model for further investigation of HS as a potential clinical approach to target tissue survival or death.
Mortality in patients with atrial fibrillation has significantly decreased during the last three decades: 35 years of follow-up in 1627 pacemaker patients (2008)

Life expectancy in AF patients after PM implantation has doubled within the last three decades, with a mean survival in the overall population of 7.6 years for women and 6.0 years for men. Survival is influenced by several simple baseline characteristics, which may help to identify patients with very long survival times.
Immune response and reactogenicity after immunization with two-doses of an experimental COVID-19 vaccine (CVnCOV) followed by a third-fourth shot with a standard mRNA vaccine (BNT162b2): RescueVacs multicenter cohort study (2022)

Partly funded by the Institute of Health Carlos-III and COVID-19 Fund, co-financed by the European Regional Development Fund (FEDER) "A way to make Europe".
Nanoparticle Assisted Remodeling of Proteotoxic SOD1 Mutants Alters the Biointerface of the Functional Interaction of Microtubules and Kinesin Motors (2019)

Transport deficits with motor neuron degeneration have been implicated in amyotrophic lateral sclerosis (ALS). We report a biomimetic system composed of microtubules/kinesin motor that mimics the dysregulated motor dynamics of ALS. Pathogenic ALS mutants A4V SOD1 completely shut off motility. Treatment with 5 nm citrate coated gold nanoparticles recovers the impaired motor stepping by remodeling the A4V SOD1 rather than stabilizing microtubules or protein folding. Instead, gold nanoparticles alter the protein by a mechanism that reforms protein elements of A4V SOD1, in turn fixing the aberrant interaction of kinesin with microtubules. Reinstating kinesin motility holds potential for managing debilitating ALS.
Tetrameric glycoprotein complex gH/gL/gQ1/gQ2 is a promising vaccine candidate for human herpesvirus 6B (2020)

Primary infection of human herpesvirus 6B (HHV-6B) occurs in infants after the decline of maternal immunity and causes exanthema subitum accompanied by a high fever, and it occasionally develops into encephalitis resulting in neurological sequelae. There is no effective prophylaxis for HHV-6B, and its development is urgently needed. The glycoprotein complex gH/gL/gQ1/gQ2 (called 'tetramer of HHV-6B') on the virion surface is a viral ligand for its cellular receptor human CD134, and their interaction is thus essential for virus entry into the cells. Herein we examined the potency of the tetramer as a vaccine candidate against HHV-6B. We designed a soluble form of the tetramer by replacing the transmembrane domain of gH with a cleavable tag, and the tetramer was expressed by a mammalian cell expression system. The expressed recombinant tetramer is capable of binding to hCD134. The tetramer was purified to homogeneity and then administered to mice with aluminum hydrogel adjuvant and/or CpG oligodeoxynucleotide adjuvant. After several immunizations, humoral and cellular immunity for HHV-6B was induced in the mice. These results suggest that the tetramer together with an adjuvant could be a promising candidate HHV-6B vaccine.
Effect of Seeding Material on ScAlN c-axis Orientation. (2020)

Abstract not provided.
Serum Metabolic Profile in Patients With Long-Covid (PASC) Syndrome: Clinical Implications (2021)

<b>Background:</b> Many patients who have been suffering by Covid-19 suffer of long-Covid syndrome, with symptoms of fatigue and muscular weakness that characterize post-acute sequelae SARS-CoV-2 infection (PASC). However, there is limited knowledge about the molecular pathophysiology, and about the serum profile of these patients. <b>Methods:</b> We studied the blood serum profile of 75 selected patients, with previous confirmed Covid-19, 2 months after hospital discharge, who reported new-onset fatigue, muscle weakness and/or dyspnea not present prior to the virus infection and independently from concomitant diseases and/or clinical conditions. <b>Results:</b> All patients had very high serum concentrations of ferritin and D-Dimer. 87 and 72% of patients had clinically significant low levels of hemoglobin and albumin, respectively. Seventy three percentage had elevations in erythrocyte sedimentation rate and CRP. Twenty seven percentage had elevations in LDH. <b>Conclusions:</b> The co-existence of patient symptoms along with blood markers of coagulation, protein disarrangement and inflammation suggests ongoing alterations in the metabolism, promoting an inflammatory/hypercatabolic state which maintains a vicious circles implicated in the persistence of PASC. The persistence of altered D-Dimer levels raises the possibility of long-term risks of thromboembolic disease. All these markers levels should be accurately evaluated in the long-term follow-up, with individualized consideration for prophylactic nutritional, anti-inflammatory and/or anticoagulant therapy if indicated.
A novel nonvolatile memory with spin torque transfer magnetization switching: spin-ram (2006)

A novel nonvolatile memory utilizing spin torque transfer magnetization switching (STS), abbreviated spin-RAM hereafter, is presented for the first time. The spin-RAM is programmed by magnetization reversal through an interaction of a spin momentum-torque-transferred current and a magnetic moment of memory layers in magnetic tunnel junctions (MTJs), and therefore an external magnetic field is unnecessary as that for a conventional MRAM. This new programming mode has been accomplished owing to our tailored MTJ, which has an oval shape of 100 times 150 nm. The memory cell is based on a 1-transistor and a 1-MTJ (ITU) structure. The 4kbit spin-RAM was fabricated on a 4 level metal, 0.18 mum CMOS process. In this work, writing speed as high as 2 ns, and a write current as low as 200 muA were successfully demonstrated. It has been proved that spin-RAM possesses outstanding characteristics such as high speed, low power and high scalability for the next generation universal memory
Microarray reveals differences in both tumors and vascular specific gene expression in de novo CD5+ and CD5- diffuse large B-cell lymphomas. (2003)

Malignant lymphoma is a heterogeneous disease with different clinical features. Among diffuse large B-cell lymphomas (DLBCLs), a unique subtype has been identified recently based on cell surface marker CD5 and clinicopathological features. These de novo CD5(+) DLBCLs account for approximately 10% of all of the DLBCLs and have poorer prognosis. To additionally understand this subtype of DLBCLs at the molecular level and to find genes that are differentially expressed in de novo CD5(+) DLBCLs, CD5(-) DLBCLs, and mantle cell lymphomas, which also have poor prognosis, we performed gene expression profiling using cDNA microarray technology. Data from a total of 9 samples of CD5(-) DLBCLs, 11 samples of de novo CD5(+) DLBCLs, and 10 samples of mantle cell lymphomas were acquired. A series of genes were identified that distinguish these three types of lymphomas. Among DLBCL cases, integrin beta1 and/or CD36 adhesion molecules were overexpressed in most cases of CD5(+) DLBCL. An immunohistochemical confirmation study revealed that integrin beta1 was expressed on lymphoma cells, which may account for the high extranodal involvement and poor prognosis of CD5(+) DLBCLs. In contrast, CD36 was overexpressed on vascular endothelia in CD5(+) DLBCLs, although there was no difference in vascularity detected by von Wilbrand factor antibody between CD5(+) and CD5(-) DLBCLs. Those results suggest that CD5(+) and CD5(-) DLBCLs have different gene expression signatures in both tumor cells and their vascular systems.
Renal Denervation Update From the International Sympathetic Nervous System Summit (2019)

Three recent renal denervation studies in both drug-naïve and drug-treated hypertensive patients demonstrated a significant reduction of ambulatory blood pressure compared with respective sham control groups. Improved trial design, selection of relevant patient cohorts, and optimized interventional procedures have likely contributed to these positive findings. However, substantial variability in the blood pressure response to renal denervation can still be observed and remains a challenging and important problem. The International Sympathetic Nervous System Summit was convened to bring together experts in both experimental and clinical medicine to discuss the current evidence base, novel developments in our understanding of neural interplay, procedural aspects, monitoring of technical success, and others. Identification of relevant trends in the field and initiation of tailored and combined experimental and clinical research efforts will help to address remaining questions and provide much-needed evidence to guide clinical use of renal denervation for hypertension treatment and other potential indications.
Lactic Acid Bacteria and Bifidobacteria with Potential to Design Natural Biofunctional Health-Promoting Dairy Foods (2017)

Consumer interest in healthy lifestyle and health-promoting natural products is a major driving force for the increasing global demand of biofunctional dairy foods. A number of commercial sources sell synthetic formulations of bioactive substances for use as dietary supplements. However, the bioactive-enrichment of health-oriented foods by naturally occurring microorganisms during dairy fermentation is in increased demand. While participating in milk fermentation, lactic acid bacteria can be exploited <i>in situ</i> as microbial sources for naturally enriching dairy products with a broad range of bioactive components that may cover different health aspects. Several of these bioactive metabolites are industrially and economically important, as they are claimed to exert diverse health-promoting activities on the consumer, such as anti-hypertensive, anti-inflammatory, and anti-diabetic, anti-oxidative, immune-modulatory, anti-cholesterolemic, or microbiome modulation. This review aims at discussing the potential of these health-supporting bacteria as starter or adjunct cultures for the elaboration of dairy foods with a broad spectrum of new functional properties and added value.
Evidence for the Direct Binding of Polyamines to a Ribonuclease that Hydrolyzes Ribonucleic Acid at Uridylic Acid Residues (1974)

Abstract The Citrobacter ribonuclease, an enzyme that cleaves preferentially phosphodiester bonds of ribonucleic acid at uridylic acid residues, has been shown to bind the polyamines, putrescine, spermidine, and spermine. The binding of spermidine insures the maintenance of enzyme activity in the presence of the polynucleotide, polyguanylic acid, at a concentration which is ordinarily completely inhibitory. Enzyme activity, if inhibited by polyguanylic acid, could, however, be restored by spermidine, which appears to effect a removal of the polynucleotide from the enzyme surface. The substitution of the polyamine for the polynucleotide was used to obtain two spermidine-bound peptides from tryptic digests of a polyguanylic acid-enzyme complex. Amino acid analysis of the isolated peptides showed that one consisted of a chain having a minimum length of 17 residues but composed of 10 different amino acids. The other had a minimum length of 8 residues and contained only 6 different amino acids. In both cases, the ratio of peptide to polyamine was approximately 1 to 1.
A Highly Reversible Lithium Metal Anode (2014)

Lithium metal has shown a lot of promise for use as an anode material in rechargeable batteries owing to its high theoretical capacity. However, it does not meet the cycle life and safety requirements of rechargeable batteries owing to electrolyte decomposition and dendrite formation on the surfaces of the lithium anodes during electrochemical cycling. Here, we propose a novel electrolyte system that is relatively stable against lithium metal and mitigates dendritic growth. Systematic design methods that combined simulations, model-based experiments, and in situ analyses were employed to design the system. The reduction potential of the solvent, the size of the salt anions, and the viscosity of the electrolyte were found to be critical parameters determining the rate of dendritic growth. A lithium metal anode in contact with the designed electrolyte exhibited remarkable cyclability (more than 100 cycles) at a high areal capacity of 12 mAh cm(-2).
Prevalence and Antimicrobial Resistance of Thermophilic Campylobacter spp. from Cattle Farms in Washington State (2005)

The prevalence of thermophilic Campylobacter spp. was investigated in cattle on Washington State farms. A total of 350 thermophilic Campylobacter isolates were isolated from 686 cattle sampled on 15 farms (eight dairies, two calf rearer farms, two feedlots, and three beef cow-calf ranches). Isolate species were identified with a combination of phenotypic tests, hipO colony blot hybridization, and multiplex lpxA PCR. Breakpoint resistance to four antimicrobials (ciprofloxacin, nalidixic acid, erythromycin, and doxycycline) was determined by agar dilution. Campylobacter jejuni was the most frequent species isolated (34.1%), followed by Campylobacter coli (7.7%) and other thermophilic campylobacters (1.5%). The most frequently detected resistance was to doxycycline (42.3% of 350 isolates). Isolates from calf rearer facilities were more frequently doxycycline resistant than isolates from other farm types. C. jejuni was most frequently susceptible to all four of the antimicrobial drugs studied (58.8% of 272 isolates). C. coli isolates were more frequently resistant than C. jejuni, including resistance to quinolone antimicrobials (89.3% of isolates obtained from calves on calf rearer farms) and to erythromycin (72.2% of isolates obtained from feedlot cattle). Multiple drug resistance was more frequent in C. coli (51.5%) than in C. jejuni (5.1%). The results of this study demonstrate that C. jejuni is widely distributed among Washington cattle farms, while C. coli is more narrowly distributed but significantly more resistant.