gebhart/patrepeval huggingface dataset:
Plasma Product Treatment in Various Types of von Willebrand’s Disease (1994)

Four different virus-inactivated factor VIII concentrates (Haemate P, Behring; Profilate, Alpha, FVIII-VHP-vWF, CRTS), near-pure von Willebrand factor (Facteur Willebrand, CRTS) or one recombinant FVIII preparation (Recombinate, Baxter) were given to one or more patients with different forms of von Willebrand's disease. Duke bleeding time, VIII:C, vWF:Ag, RC of activity, and the multimeric pattern of plasma vWF were monitored. Both Duke bleeding time and the multimeric pattern were normalized after treatment with Haemate P, FVIII-VHP-vWF, or Facteur Willebrand, and to a lesser extent after Profilate. Except in one case, the reduction in bleeding time lasted longer after Haemate P than after the other concentrates. Recombinate had no effect on primary hemostasis, and the half-life of VIII:C was very short. If prompt hemostasis is required, and when pharmacological correction of the defect is impossible, we recommend a concentrate containing both FVIII and the full complement of vWF multimers, but for prophylactic treatment pure von Willebrand factor may be used.
Modeling Processor Idle Times in MPSoC Platforms to Enable Integrated DPM, DVFS, and Task Scheduling Subject to a Hard Deadline (2018)

Energy efficiency is one of the most critical design criteria for modern embedded systems such as multiprocessor system-on-chips (MPSoCs). Dynamic voltage and frequency scaling (DVFS) and dynamic power management (DPM) are two major techniques for reducing energy consumption in such embedded systems. Furthermore, MPSoCs are becoming more popular for many real-time applications. One of the challenges of integrating DPM with DVFS and task scheduling of real-time applications on MPSoCs is the modeling of idle intervals on these platforms. In this paper, we present a novel approach for modeling idle intervals in MPSoC platforms which leads to a mixed integer linear programming (MILP) formulation integrating DPM, DVFS, and task scheduling of periodic task graphs subject to a hard deadline. We also present a heuristic approach for solving the MILP and compare its results with those obtained from solving the MILP.
Antihepatotoxic Actions of Ginsenosides fromPanax ginsengRoots1 (1985)

The antihepatotoxic effects of ginsenosides, saponins from PANAX GINSENG, and their aglycones were investigated utilizing carbon tetrachloride (CCl (4))- and galactosamine (GalN)-induced cytotoxicity in primary cultured rat hepatocytes. Prominent protective actions were found with 20( S)-ginsenoside-Rh (2), 20( R)-ginsenoside-Rg (3) and prosapogenin of ginsenoside-Ro, 20( R)- and 20( S)-ginsenoside-Rs in CCl (4)-produced cytotoxicity, and 20( S)-ginsenoside-Rh (1) and prosapogenin of 20( S)-ginsenoside-Rs were effective in preventing GalN-induced liver cell damage. The antihepatotoxic effects of chikusetsusaponins, saponins of PANAX JAPONICUS, were also examined. The structure-activity relationship is discussed.
Medical ethics and the judicial coerced treatment of sexual abusers (1998)

The increasing demand for judicial coerced treatment of sexual abusers constitutes a new challenge for mental health professionals. The discussed controversial ethical issues are the influence of coercion on the treatment, the motivation of patient as well as therapist, confidentiality and hormonal treatment. Social control is not the primary concern of therapists and any treatment must be beneficial to the individual patient. The coerced treatment of sexual abusers requests an agreement between psychiatric and judicial authorities with respect for their respective professional ethics.
Broad-Band Personal Computer LAN's (1985)

Broad-band technology provides several advantages for personal computer local area networks (PC LAN's) including mature readily available transmission technology, large total bandwidth, support for multiple services, and cost-effective expansion from very small to very large systems. This paper presents an overview of basic broad-band technology, hardware, software, and protocols needed for PC LAN's. Gateways and network management are also considered. Recent PC LAN products are compared, with a more detailed case study of the PC LAN developed by IBM and Sytek.
Charge Separation and Charge Distribution in Rearrangement Reactions of β-(Phosphatoxy)alkyl Radicals (2004)

Unimolecular reaction pathways for the 2-(dimethylphosphatoxy)-2-(p-methoxyphenyl)-1,1,-dimethylethyl radical 1 have been studied with several different hybrid density functional methods. The most reliable prediction has been obtained through combination of relative energies calculated at the BHLYP/6-311+G(d,p)//Becke3LYP/6-31G(d) level of theory with solvation free energies calculated with the PCM (polarizable continuum) model for THF. All reaction pathways characterized in detail have mixed homolytic/heterolytic character with a dominating heterolytic component. Concerted reaction pathways for 1,2- and 3,2-migration of the phosphate group lead to rearranged benzylic radical 2 that is more stable than 1 by about 30 kJ/mol. Also, a flat region of the potential energy surface has been identified that contains intermediates of nonintegral charge separation. This region of the potential energy surface can be reached from the reactant radical 1, the rearranged radical 2, and the phosphoric acid elimination products 11 and 12. The intermediates located on this part of the potential energy surface can best be described as contact radical ion pairs based on their overall geometrical structure. However, the phosphate group charges never exceed a value of −0.75 even in THF solution. The absolute reaction barriers are strongly influenced through the presence of a solvent reaction field even for a low-polarity solvent such as THF and thus show the expected behavior for a charge-separating reaction type. The gas-phase UV−vis excitation spectrum calculated for contact radical ion pairs using the adiabatic TDDFT approximation features a very long wavelength absorption between 900 and 1000 nm absent in the spectrum of the underlying radical cation whose longest wavelength absorption is predicted to be at 555 nm. The results of the TDDFT computations have been confirmed by coupled-cluster calculations employing the CC2 approximation.
Artificial intelligence application for rapid fabrication of size-tunable PLGA microparticles in microfluidics (2020)

In this study, synthetic polymeric particles were effectively fabricated by combining modern technologies of artificial intelligence (AI) and microfluidics. Because size uniformity is a key factor that significantly influences the stability of polymeric particles, therefore, this work aimed to establish a new AI application using machine learning technology for prediction of the size of poly(D,L-lactide-co-glycolide) (PLGA) microparticles produced by diverse microfluidic systems either in the form of single or multiple particles. Experimentally, the most effective factors for tuning droplet/particle sizes are PLGA concentrations and the flow rates of dispersed and aqueous phases in microfluidics. These factors were utilized to develop five different and simple in structure artificial neural network (ANN) models that are capable of predicting PLGA particle sizes produced by different microfluidic systems either individually or jointly merged. The systematic development of ANN models allowed ultimate construction of a single in silico model which consists of data for three different microfluidic systems. This ANN model eventually allowed rapid prediction of particle sizes produced using various microfluidic systems. This AI application offers a new platform for further rapid and economical exploration of polymer particles production in defined sizes for various applications including biomimetic studies, biomedicine, and pharmaceutics.
An appraisal of certain problems involved in the use of steroid compounds for contraception. (1966)

The problems of oral contraception considered are: possible carcinogenesis, thrombophlebitis or thromboembolism, and possible effect on the reproductive or genetic potential of the ova. Estrogen-progestogen combinations produce characteristic effects of estrogen, indicating that the estrogen given exceeds normal endogenous estrogen production. In humans all known carcinogenic agents involve a latent period, many for a decade or more. Both endogenous and exogenous estrogens have been shown to modify the activity of established breast cancer in humans. The effect on the preclinical phases is unknown. Effects of prolonged use of estrogens on breast cancer will require more extensive studies. Endometrial cancer has been reported to undergo regression under intensive progesterone therapy. Other known carcinolytic agents such as X-rays and alkylating substances are known to be carcinogenic under some conditions. One may, therefore, question the advisability of derangement of such endocrinological relationships. Distinctive histological changes in the endometrium after use of estrogen-progestogen mixtures have been described. Such atrophic changes represent drug-induced pathology. Although these changes disappear when therapy is discontinued, the latent effect is unknown. Since the pathogenic period for cancer of the cervix is estimated to be 7-10 years, studies of this possible effect should exceed this time span and be carefully devised so that data can be compared. Data reported so far do not provide a sound statistical basis. Immediate effects on cervical dysplasia have not been shown to be unfavorable. Thrombophlebitis and thromboembolic phenomena have been reported but on the basis of available data no significant increase in risk has been demonstrated. Studies of carcinogenesis in animals are readily reproduced. However, the human population is so heterogenous that the genetic factor is uncertain. The ultimate effect of oral contraceptives on the ova is unknown. So far observations have shown none. Each physician prescribing these drugs should evaluate the risks involved with due regard for the results of alternate methods of contraception available.
Low cost DIY solar energy hot water system (2005)

Abstract – This paper describes a low cost hot water system for domestic use. The system is very simple, low in cost, and can be made without any sophisticated equipment and manufacturing tools.
Active Learning for Large-Scale Entity Resolution (2017)

Entity resolution (ER) is the task of identifying different representations of the same real-world object across datasets. Designing and tuning ER algorithms is an error-prone, labor-intensive process, which can significantly benefit from data-driven, automated learning methods. Our focus is on "big data'' scenarios where the primary challenges include 1) identifying, out of a potentially massive set, a small subset of informative examples to be labeled by the user, 2) using the labeled examples to efficiently learn ER algorithms that achieve both high precision and high recall, and 3) executing the learned algorithm to determine duplicates at scale. Recent work on learning ER algorithms has employed active learning to partially address the above challenges by aiming to learn ER rules in the form of conjunctions of matching predicates, under precision guarantees. While successful in learning a single rule, prior work has been less successful in learning multiple rules that are sufficiently different from each other, thus missing opportunities for improving recall. In this paper, we introduce an active learning system that learns, at scale, multiple rules each having significant coverage of the space of duplicates, thus leading to high recall, in addition to high-precision. We show the superiority of our system on real-world ER scenarios of sizes up to tens of millions of records, over state-of-the-art active learning methods that learn either rules or committees of statistical classifiers for ER, and even over sophisticated methods based on first-order probabilistic models.
Lightweight Authentication for Quantum Key Distribution (2020)

Quantum key distribution (QKD) enables unconditionally secure communication between distinct parties using a quantum channel and an authentic public channel. Reducing the portion of quantum-generated secret keys, that is consumed during the authentication procedure, is of significant importance for improving the performance of QKD systems. In the present work, we develop a lightweight authentication protocol for QKD based on a `ping-pong' scheme of authenticity check for QKD. An important feature of this scheme is that the only one authentication tag is generated and transmitted during each of the QKD post-processing rounds. For the tag generation purpose, we design an unconditionally secure procedure based on the concept of key recycling. The procedure is based on the combination of almost universal <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> polynomial hashing, XOR universal <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> Toeplitz hashing, and one-time pad (OTP) encryption. We demonstrate how to minimize both the length of the recycled key and the size of the authentication key, that is required for OTP encryption. As a result, in real case scenarios, the portion of quantum-generated secret keys that is consumed for the authentication purposes is below 1%. Finally, we provide a security analysis of the full quantum key growing process in the framework of universally composable security.
Triplet Photosensitized para-Hydrogen Induced Polarization (2022)

Despite its enormous utility in structural characterization, nuclear magnetic resonance (NMR) spectroscopy is inherently limited by low spin polarization. One method to address the low polarization is <i>para</i>-hydrogen (<i>p</i>-H<sub>2</sub>) induced polarization (PHIP) which uses the singlet spin isomer of H<sub>2</sub> to generate disparate nuclear spin populations to amplify the associated NMR signals. PHIP often relies on thermal catalysis or, more infrequently, UV-activated catalytic hydrogenation. Light-activated hydrogenation enables direct and timed control over the hyperpolarization of target substrates, critical for identifying short-lived intermediates. Here, we use an established Ir(III) triplet photosensitizer (<b>PS</b>) to visible light sensitize the triplet ligand-field states in the d<sup>6</sup>-transition metal dihydride Ru(CO)(PPh<sub>3</sub>)<sub>3</sub>(H)<sub>2</sub> (<b>1</b>). Excitation inside a 9.4 T NMR spectrometer with the <b>PS</b> and a 420 nm blue LED, under 3 atm of <i>p</i>-H<sub>2</sub>, successfully photosensitized hyperpolarization in <b>1</b> and in a range of unsaturated substrates at and below room temperature, up to 1630-fold. In otherwise identical experimental conditions without light activation, no polarization was realized in <b>1</b> or the substrates evaluated. We believe triplet-sensitized PHIP (Trip-PHIP) represents a facile experimental means for probing triplet sensitized light activation in transition metal catalysts possessing low-lying triplet ligand-field states, providing mechanistic insight of potentially tremendous value in chemical catalysis.
Mutational Effects on Carbapenem Hydrolysis of YEM-1, a New Subclass B2 Metallo-β-Lactamase from Yersinia mollaretii (2020)

Analysis of the genome sequence of <i>Yersinia mollaretii</i> ATCC 43969 identified the <i>bla</i><sub>YEM</sub> gene, encoding YEM-1, a putative subclass B2 metallo-β-lactamase. The objectives of our work were to produce and purify YEM-1 and to complete its kinetic characterization. YEM-1 displayed the narrowest substrate range among known subclass B2 metallo-β-lactamases, since it can hydrolyze imipenem, but not other carbapenems, such as biapenem, meropenem, doripenem, and ertapenem, with high catalytic efficiency. A possible explanation of this activity profile is the presence of tyrosine at residue 67 (loop L1), threonine at residue 156 (loop L2), and serine at residue 236 (loop L3). We showed that replacement of Y67 broadened the activity profile of the enzyme for all carbapenems but still resulted in poor activity toward the other β-lactam classes.
Coordinated Scheduling For Wireless Backhaul Networks With Soft Frequency Reuse (2013)

Publication in the conference proceedings of EUSIPCO, Marrakech, Morocco, 2013
Itraconazole cyclodextrin solution—effective treatment for HIV-related candidosis unresponsive to other azole therapy (1994)

Journal Article Itraconazole cyclodextrin solution—effective treatment for HIV-related candidosis unresponsive to other azole therapy Get access J. D. CARTLEDGE, J. D. CARTLEDGE HIV/Genito-urinary Medicine Unit, Chelsea and Westminster Hospital369 Fulham Road, London SW10 9NH, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar J. MIDGLEY, J. MIDGLEY HIV/Genito-urinary Medicine Unit, Chelsea and Westminster Hospital369 Fulham Road, London SW10 9NH, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar M. YOULE, M. YOULE HIV/Genito-urinary Medicine Unit, Chelsea and Westminster Hospital369 Fulham Road, London SW10 9NH, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar B. G. GAZZARD B. G. GAZZARD a HIV/Genito-urinary Medicine Unit, Chelsea and Westminster Hospital369 Fulham Road, London SW10 9NH, UK aCorresponding author Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Antimicrobial Chemotherapy, Volume 33, Issue 5, May 1994, Pages 1071–1073, https://doi.org/10.1093/jac/33.5.1071 Published: 01 May 1994
Manakov Polarization Modulation Instability in Normal Dispersion Optical Fiber (2014)

We observed polarization modulation instability in the normal dispersion regime of randomly birefringent multi-km telecom optical fiber. The instability is pumped by two wavelength multiplexed and orthogonally polarized intense continuous lasers.
A STlUIY OF CAKINE ENCEPHALITIS (1950)

Journal Article A STlUIY OF CAKINE ENCEPHALITIS Get access H. KOPROWSKI, H. KOPROWSKI Search for other works by this author on: Oxford Academic PubMed Google Scholar G. A. JERVIS, G. A. JERVIS Search for other works by this author on: Oxford Academic PubMed Google Scholar T. R. JAMES, T. R. JAMES Search for other works by this author on: Oxford Academic PubMed Google Scholar R. L. BURKHART, R. L. BURKHART Search for other works by this author on: Oxford Academic PubMed Google Scholar G. C. POPPENSIEK G. C. POPPENSIEK Search for other works by this author on: Oxford Academic PubMed Google Scholar American Journal of Epidemiology, Volume 51, Issue 1, January 1950, Pages 63–75, https://doi.org/10.1093/oxfordjournals.aje.a119377 Published: 01 January 1950 Article history Received: 09 September 1949 Published: 01 January 1950
Fitting long-memory models by generalized linear regression (1993)

There is an increasing awareness of the importance of long-memory models in statistical applications. If long memory is present, it has to be taken into account in order to obtain reliable tests and confidence intervals. One obstacle to using models with long memory in routine statistical analysis has been the lack of easily available and sufficiently versatile statistical software. Here we propose a simple but flexible class of parametric models, which can be used to model such behaviour. We demonstrate that these models can be fitted by generalized linear regression. Standard statistical software packages can be used. A data example is discussed.
A Risk Prediction Model Based on Lymph-Node Metastasis in Poorly Differentiated–Type Intramucosal Gastric Cancer (2016)

A RSS could be useful in clinical practice to determine which patients with intramucosal PDC have low risk of LNM.
Cloning and expression of the ε4 subunit of the NMDA receptor channel (1992)

The primary structure of a novel subunit of the mouse NMDA (N-methyl-D-aspartate) receptor channel, designated epsilon 4, has been revealed by cloning and sequencing the cDNA. The epsilon 4 subunit shares high amino acid sequence identity with the epsilon 1, epsilon 2 and epsilon 3 subunits of the mouse NMDA receptor channel, thus constituting the epsilon subfamily of the glutamate receptor channel. Expression from cloned cDNAs of the epsilon 4 subunit together with the zeta 1 subunit in Xenopus oocytes yields functional NMDA receptor channels. The epsilon 4/zeta 1 heteromeric channel exhibits high apparent affinities for agonists and low sensitivities to competitive antagonists. The epsilon 4 subunit is thus distinct in functional properties from the epsilon 1, epsilon 2 and epsilon 3 subunits, and contributes further diversity of the NMDA receptor channel.
Simulation of Ad Hoc Networks: ns-2 compared to JiST/SWANS (2008)

For the evaluation of ad hoc network protocols, researchers traditionally use simulations because they easily allow for a large number of nodes and reproducible environment condi- tions. But still, simulations are costly in terms of required processing time and memory. New approaches like the Java-
A Novel, Fast, Reliable Data Transmission Algorithm for Wireless Machine Health Monitoring (2009)

Vibration-based machine health monitoring is a well-known technique that is commonly used in machine fault diagnosis applications. In conjunction with existing wireless technologies, even machines that are operated in a hazardous or moveable environment can be monitored wirelessly. However, to facilitate a reliable machine health assessment, various sensory data, particularly the vibration signals, must be acquired at a high sampling rate, generating large packets of data. These requirements are impractical in a wireless data transmission context due to the usual low transmission rate, and lengthy transmission time. One possible solution is to compress the captured numerous sensory data before wireless transmission commences. This paper presents a novel data compression algorithm that combines Empirical Mode Decomposition (EMD) with Differential Pulse Code Modulation (DPCM). EMD is effective in decomposing and identifying any instantaneous changes in non-linear, and non-stationary signals that are caused by anomalous operation of machines. After the data have been decomposed and compressed by EMD, the DPCM is applied to further compress the data through the use of linear predictor and quantizer prior to wireless transmission. A pair of Bluetooth based wireless devices was tailor-made to host the EMD and DPCM for performing wireless communication. The effectiveness of the new algorithm has been verified using real machines, operating in a noisy environment. The results prove that the algorithm provides much faster wireless data transmission by significantly reducing the size of sensory data. Nevertheless, it maintains the integrity of sensory data with negligible reconstruction error at the receiving end of the wireless device.
1,3-Diamino-2-hydroxypropane-N,N,N′,N′-tetraacetic acid stabilized amorphous calcium carbonate: nucleation, transformation and crystal growth (2009)

A low molecular weight organic molecule, 1,3-diamino-2-hydroxypropane-N,N,N′,N′-tetraacetic acid, has been found that it could stabilize amorphous calcium carbonate (ACC) for at least three days in a gas diffusion reaction, also it could control the formation of hierarchical calcite crystals. The transformation process from ACC to calcite crystals has been systematically studied. Nucleation sites and intermediates were both captured by time-dependent experiments. It is found that ACC could form a close packed film on the substrate and part of the nucleation occurred on the film. After nucleation, another form of ACC conglomeration was found to be dissolved from inside. The intermediates on the substrate were found to be composed of fibres. A rod-dumbbell-sphere transformation phenomenon was observed. Selective adsorption and the mesocrystal transformation mechanism are assumed to play a key role in the formation of intermediates with different shapes and structures.
Design and manufacture of low-absorption ZnS-YF3 antireflection coatings in the 3.5-16-mu m spectral range (1998)

International audience