gebhart/patrepeval huggingface dataset:
Monoclonal Antibodies for Affinity Purification of IL-6/IFN-β 2 and for Neutralization of HGF Activity (1989)

Two types of recombinant human IL-6 (rIL-6) were used for the development of specific monoclonal antibodies. The first was produced in E. coli and used for immunization, the second was produced in Chinese Hamster Ovary Cells (CHO) and used for screening. The complete translated sequence of the cDNA coding for human IL-6 was fused, in phase, to protein-A and the hybrid gene was fused to the strong lambda PR promoter. This protein was purified from bacterial extracts by chromatography on rabbit IgG-Sepharose columns. After six injections of the purified protein into mice, sera were tested for their binding titer in a solid phase radioimmunassay (sRIA) and for the specificity of binding by Western blots. In the sRIA, crude supernatants of CHO cells (harboring a plasmid containing the human IL-6 gene and expressing high levels of IL-6 but no protein-A or any bacterial antigen) were bound to a solid support, reacted with supernatants of the hybridomas and finally detected with [125I]-goat anti-mouse antibodies. Spleen cells derived from a mouse showing the highest binding titer were fused to mouse myeloma cells. The hybridomas were screened by the sRIA and several positive clones were isolated and characterized. One of the clones was found to neutralize the hybridoma growth factor activity of the rIL-6 from both sources. The same clone was also used for Western blots and for affinity purification of both natural and recombinant IL-6 (E. coli and CHO).
2P1-K04 Action planning for Robot Arm adopting Kukanchi(Integrating Ambient Intelligence) (2011)

The purpose of this research is to construct a system that can navigate arm robot adopting Kukanchi (Interactive Human-Space Design and Intelligence). This system gets ID and place of objects on work area form database that lumps information of objects in the intelligent space. The database is built up by sensors that implanted in several places. And then, this system generates disposition map of work area and operation for object manipulation. As a result, this map and operation make it possible to avoid obstacles when the arm grips the object. This paper reports about configuration and evaluation of the system.
Improved thermoelectric performance in polycrystalline p-type Bi2Te3 via an alkali metal salt hydrothermal nanocoating treatment approach (2008)

We report herein a proof-of-principle study of grain boundary engineering in the polycrystalline p-type Bi2Te3 system. Utilizing the recently developed hydrothermal nanocoating treatment technique, we fabricated an alkali-metal(s)-containing surface layer on the p-Bi2Te3 bulk grain, which in turn became part of the grain boundary upon hot pressing densification. Compared to the untreated bulk reference, the dimensionless figure of merit ZT has been improved by ∼30% in the Na-treated sample chiefly due to the reduced thermal conductivity, and ∼38% in the Rb-treated sample mainly owing to the improved power factor. The grain boundary phase provides a new avenue by which one can potentially decouple the otherwise inter-related electrical resistivity, Seebeck coefficient, and thermal conductivity within one thermoelectric material.
Relationship Between Maternal Serum Cortisol and Maternal Insulin Resistance and Fetal Ultrasound Characteristics in Gestational Diabetes Mellitus (2023)

Serum cortisol levels in GDM correlated with fasting blood glucose, triglycerides, and insulin resistance. Besides, serum cortisol levels in GDM positively correlated with fetal development.
Controllability of molecular systems (1995)

In this paper we analyze the controllability of quantum systems arising in molecular dynamics. We model these systems as systems with finite numbers of levels, and examine their controllability. To do this we pass to their unitary generators and use results on the controllability of invariant systems on Lie groups. Examples of molecular systems, modeled as finite-dimensional control systems, are provided. A simple algorithm to detect the controllability of a molecular system is provided. Finally, we apply this algorithm to a five-level system.
Structure and Infrared Emissivity Properties of the MAO Coatings Formed on TC4 Alloys in K2ZrF6-Based Solution (2018)

Micro-arc oxidation (MAO) ceramic coatings were formed on TC4 alloy surface in silicate and metaphosphate electrolytes based with K₂ZrF₆ for various concentrations. X-ray diffraction (XRD), Scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS) were used to characterize the phase composition, microstructure and chemical compositions of the coatings. The infrared emissivity of the coatings was measured at 50 °C in a wavelength range of 8-20 µm. The microstructural observations all revealed the typical porousstructures. Moreover, adecline in roughness and thickness of the prepared coatings can be observed when the concentration of K₂ZrF₆ increases. Combined with the results of XRD and XPS, it was found that all the oxides existed as the amorphous form in the coatings except the TiO₂ phase. The coatings exhibited the highest infrared emissivity value (about 0.89) when the concentration of K₂ZrF₆ was 6 g/L, which was possibly attributed to the defect microstructure and the optimal role of ZrO₂.
702. Long Term Metabolic Correction of Wilson Disease (2015)

Wilson disease (WD) is an autosomal recessively inherited copper storage disorder due to mutations in the ATP7B gene resulting in impaired biliary copper excretion and hepatic copper accumulation. The increased hepatic copper concentration causes hepatocellular injury of variable intensity from acute liver failure to chronic hepatitis evolving to cirrhosis. Most often the first manifestation of the disorder is the hepatic disease which may be followed by copper deposition in the brain with resulting neurological damage. Current treatments are based on copper chelators that promote urinary excretion of the metal. These therapies should be maintained lifelong, may cause side effects and do not restore normal copper metabolism. In this work we assessed the efficacy of gene therapy to treat this condition. We transduced the liver of Atp7b-/- mice (a model of WD) with an adeno-associated vector serotype 8 (AAV8) encoding the human ATP7B cDNA placed under the control of the liver-specific a1-antitripsin promoter. After vector administration we performed serial determinations of serum transaminases, serum holoceruloplasmin concentration and ferroxidase activity and urinary copper excretion. In addition we assessed liver cooper concentration, oxidative status of hepatic proteins and histological liver damage in samples obtained at 6 months after therapy. We observed a dose-dependent therapeutic effect manifested by the reduction of transaminasemia and urinary copper excretion and normalization of serum holoceruloplasmin. Furthermore, we documented complete reversal of all hepatic alterations, including copper content, histopathological changes and protein oxidation. Conclusion: our data demonstrate that gene therapy provides long term correction of WD in a clinically relevant animal model of this disorder.
Effect of Synthetic Link N Peptide on the Expression of Type I and Type II Collagens in Human Intervertebral Disc Cells (2010)

Intervertebral disc (IVD) degeneration is associated with proteolytic degradation of proteoglycan aggregates present within the extracellular matrix of the disc. Link N peptide (DHLSDNYTLDHDRAIH) is the N-terminal peptide of link protein, which stabilizes the proteoglycan aggregates. It is generated in vivo by proteolytic degradation during tissue turnover. It has been previously shown that this peptide can stimulate the synthesis of collagens by articular cartilage and bovine IVD cells in vitro. Being a synthetic peptide, Link N has considerable financial benefits for clinical use over recombinant growth factors because it is extremely cheap to produce. The purpose of the present study was to determine the effect of Link N on the expression of types I and II collagen and investigate the cellular mechanisms of Link N signal transduction in human IVD cells. The present results suggest that Link N stimulates the expression of types I and II collagen in human IVD cells. More specifically, Link N stimulated the expression of type I in nucleus pulposus (NP) cells, but not in annulus fibrosus cells. As Link N also decreased the phosphorylation of p38 in NP cells only, results suggest that p38 is a mediator of the effect of Link N on type I collagen expression. p38 is a member of the mitogen-activated protein kinase family highlighted by three major cascades: p38, c-Jun amino-terminal kinase, and extracellular signal-regulated kinase pathways. Link N showed no effect on the latter two pathways, suggesting a specific effect of Link N on the p38 cascade. On the other hand, Link N stimulated the expression of type II collagen in both NP and annulus fibrosus, suggesting that other mechanisms are implicated in the control of type II collagen expression in disc cells, without excluding p38 for the NP. In conclusion, the present study showed that Link N can modulate the expression of collagen in human IVD cells.
Proton Irradiation Effects in Mos and Junction Field-Effect Transistors and Integrated Circuits (1966)

Because of the application of field-effect transistors, and integrated circuits in space electronic systems and the fact that proton irradiation data at energies typical of a space environment are not extensive, an experimental evaluation of these devices has been conducted. Thee important electrical parameters of these devices were measured before, during, and after irradiation at the Oak Ridge National Laboratory's 22-Mev Cyclotron. The results obtained from the MOS field-effect study show that their degradation processes include that of charge storage in the silicon dioxide insulating layer and radiation-induced changes in surface states. MOS transistors have been found to degrade at orders of magnitude less integrated proton flux than many bipolar and junction field-effect transistors; therefore, for space applications in radiation fields such as Van Allen Belts and solar particle events, these devices may be subject to serious radiation damage. The junction field-effect transistor desplays a large initial spread in device irradiation response. However, it appears to possess a high degree of resistance to proton irradiation. The integrated circuits tested were of the monolithic type and under proton irradiation displayed a large reduction of minority carrier lifetime in the base region of the circuit transistors. Other less important defects are reduction of free carrier concentration and reduction in mobility. Important electrical parameters that are affected by radiation are imput threshold voltages, output low level voltages, leakages currents, and transient characteristics. In conclusion, MOS field-effect transistors and integrated circuits display significant damage characteristics when subjected to a space proton environment.
Auditory Risk of Exploding Hydrogen−Oxygen Balloons (2010)

Although hydrogen−oxygen balloon explosions are popular demonstrations, the acoustic impulse created poses a hearing damage risk if the peak level exceeds 140 dB at the listener’s ear. The results of acoustical measurements of hydrogen−oxygen balloons of varying volume and oxygen content are described. It is shown that hydrogen balloons may be used without auditory risk to typically situated participants. It is further shown that even small (∼0.1 mol total) hydrogen−oxygen balloons cannot be exploded without precaution, that is, ensuring that participants have hearing protection or are located sufficiently far away. In all cases, it is recommended that the presenter wear hearing protection.
Baseline of virtual cameras acquired by a standard plenoptic camera setup (2014)

Plenoptic cameras have been used to computationally generate viewpoint images from the captured light field. This paper aims to provide a prediction of corresponding virtual camera positions based on the parameters of a standard plenoptic camera setup. Furthermore, by tracing light rays from the sensor to the object space, a solution is proposed to estimate the baseline of viewpoints. By considering geometrical optics, the suggested approach has been implemented in Matlab and assessed using Zemax, a real ray tracing simulation tool. Thereby, the impact of different main lens locations is investigated. Results of the baseline approximation indicate that estimates obtained by the proposed model deviate by less than 0.2% compared to the complex real ray tracing method.
Breast Sensation Recovery After Neurotized Deep Inferior Epigastric Perforator Reconstruction (2019)

BACKGROUND: It has been proven that breast reconstruction and the improvement of the breast sensation for postmastectomy patients can improve both satisfaction and quality of life for patients.1 Spontaneous sensory recovery after deep inferior epigastric perforator (DIEP) flap has been showed due to ingrowth of peripheral cutaneous nerves from the wound edges or from deeper structures but usually is poor and variable. Neurotization has been used in breast reconstruction since 1992, and the limitation of only using the intercostal nerves for coaptation is the need of a greater chest dissection to have an appropriate nerve length that generates scar formation and tension on the suture line.2,3,4 Using a nerve conduit with a nerve graft will reduce excess nerve dissection that will jeopardize nerve regeneration and can help to overcome the size mismatch between the intercostal nerve and the DIEP intercostal nerve.4,3 PURPOSE: To evaluate breast sensation outcomes after combined nerve conduit and allograft in DIEP reconstructions. METHODS: Dynamic and static sensation recovery tests were performed in all breast quadrants of consecutive patients who underwent DIEP reconstruction with neurotized (group 1) and non-neurotized DIEP reconstructions (group 2). Demographics information, surgical details, and postoperative complications were collected. RESULTS: A total of 74 patients (96 breasts) underwent this technique since June 2016: 46 breasts from group 1 and 15 from group 2. The groups had similar age, body mass index, smoking status, history of radiation therapy, and timing of reconstruction. No difference was found for complications and reoperation between groups. The mean time interval among the surgery, first, and second tests were similar in groups 1 and 2. Thresholds on the first and second recovery tests were statistically similar. Compared to group 2, group 1 had 56% of the total areas evaluated (static and dynamic) with better sensation thresholds. On the second round of sensation tests, the clinical difference between the groups was more evident with all areas with better sensation thresholds in the neurotized group. CONCLUSION: There is a positive trend for breast sensation recovery after reconstruction with neurotized DIEP flaps. Nerve regeneration takes time to be achieved, and a longer follow-up is necessary to evaluate the final sensation recovery. REFERENCES: 1. Cornelissen AJM, Beugels J, van Kuijk SMJ, et al. Sensation of the autologous reconstructed breast improves quality of life: a pilot study. Breast Cancer Res Treat. 2018;167:687–695. 2. Blondeel PN, Demuynck M, Mete D, et al. Sensory nerve repair in perforator flaps for autologous breast reconstruction: sensational or senseless? Br J Plast Surg. 1999;52:37–44. 3. Spiegel AJ, Menn ZK, Eldor L, et al. Breast reinnervation: DIEP neurotization using the third anterior intercostal nerve. Plast Reconstr Surg Glob Open. 2013;1:e72. 4. Bassilios Habre S, Bond G, Jing XL, et al. The surgical management of nerve gaps: present and future. Ann Plast Surg. 2018;80:252–261.
Acertar a la primera: desarrollo innovador de relés inteligentes de gama baja para aplicaciones (2008)

Al aumento de la demanda de dispositivos electrónicos inteligentes de gama baja (IED), ABB responde con el desarrollo de su propia cartera de relés de gama baja. En este contexto, la compañía inició su programa "Cougar" a finales de 2005. El objetivo inmediato de este programa era abordar el desarrollo de los tipos de relés REJ 601, REF 601 y REJ 603. REJ 601 y REF 601 son relés accionados con motor auxiliar que proporcionan protección trifásica contra sobreintensidad y fallo de tierra con interfaces de sensor Rogowski. El REJ 603 es un relé autoalimentado para protección trifásica contra sobreintensidad y fallo de tierra con una interfaz de transformador de corriente personalizada. El REJ 603 fue el primero de estos productos en aparecer en el mercado. Poco después se produjo la presentación del REF 601.
Modeling the limitations imposed by the timing jitter/skew on the time-based ADC performance (2014)

Time-based ADC is an essential block in designing software radio receivers because it exhibits higher speed and lower power compared to the conventional ADC, especially, at scaled CMOS technologies. In time-based ADCs, the input voltage is first converted to a pulse delay time by using a Voltage-to-Time Converter (VTC) circuit, and then the pulse delay time is converted to a digital word by using a Time-to-Digital Converter (TDC) circuit. In this paper, an analytical model for the timing jitter and skew due to noise and process variations, respectively, is proposed for the VTC circuit. The derived model is verified and compared to Monte Carlo simulations and Eldo transient noise simulations by using industrial 65-nm CMOS technology. This paper provides new design insights such as the impact of timing jitter/skew on the ADC resolution and the maximum input voltage frequency.
Local Delivery of Gene Vectors From Bare-Metal Stents by Use of a Biodegradable Synthetic Complex Inhibits In-Stent Restenosis in Rat Carotid Arteries (2008)

Reversible immobilization of adenovirus vectors on the bare-metal surfaces of endovascular stents via a synthetic complex represents an efficient, tunable method for sustained release of gene vectors to the vasculature.
Antagonistic Actionsin Vivoof (23S)-25-Dehydro-1α-Hydroxyvitamin D3-26,23-Lactone on Calcium Metabolism Induced by 1α,25-Dihydroxyvitamin D3 (2001)

The vitamin D analog, (23S)-25-dehydro-1alpha-hydroxyvitamin D(3)-26,23-lactone (TEI-9647), is an antagonist of the 1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)] nuclear receptor (VDR)-mediated differentiation of human leukemia (HL-60) cells. To clarify whether TEI-9647 could function as an antagonist of 1alpha,25(OH)(2)D(3) in vivo, we investigated in vitamin D-deficient (-D) rats the effects of single doses of TEI-9647 on several parameters of calcium metabolism modulated by 1alpha,25(OH)(2)D(3). TEI-9647 (50 microgram/kg iv) acting alone slightly, but significantly, stimulated intestinal calcium transport (ICA) and bone calcium mobilization (BCM) only at 8 h, but not at 24 h. In contrast, TEI-9647 dose-dependently inhibited ICA and BCM stimulated by an iv dose of 0.25 microgram/kg 1alpha,25(OH)(2)D(3) after 24 h, but not after 8 h. With respect to serum PTH levels, the administration of either TEI-9647, 50 microgram/kg, or 1alpha,25(OH)(2)D(3), 0.25 microgram/kg, began to decrease the circulating levels by 4 h, which reached a nadir 24 h after administration. But, when TEI-9647 and 1alpha,25(OH)(2)D(3) were simultaneously administered to -D rats, the TEI-9647 dose-dependently reversed the inhibition of PTH secretion caused by 1alpha,25(OH)(2)D(3), 0.25 microgram/kg, at 8 and 24 h after the treatment. In separate experiments, the daily iv administration of 20 microgram/kg of TEI-9647 alone to +D rats for 2 weeks resulted in no significant changes in the prevailing serum Ca(2+) concentration. But doses of 1-20 microgram/kg of TEI-9647 in combination with 0.5 microgram/kg of 1alpha,25(OH)(2)D(3), for 2 weeks, dose-dependently and significantly suppressed the serum calcium concentration increase caused by the 1alpha,25(OH)(2)D(3). Collectively, these results show that TEI-9647 acting alone displays in vivo weak agonistic actions, but when administered in combination with 1alpha,25(OH)(2)D(3), is a potent antagonist of three genomic-mediated calcium metabolism parameters. We conclude that TEI-9647 can also function as an antagonist of 1alpha,25(OH)(2)D(3) in vivo in the rat.
Temperature-Dependent Optical Band Gap in CsPbBr3, MAPbBr3, and FAPbBr3 Single Crystals (2020)

Single crystals represent a benchmark for understanding the bulk properties of halide perovskites. We have indeed studied the dielectric function of lead bromide perovskite single crystals (MAPbBr<sub>3</sub>, CsPbBr<sub>3</sub> and for the first time FAPbBr<sub>3</sub>) by spectroscopic ellipsometry in the range of 1-5 eV while varying the temperature from 183 to 440 K. An extremely low absorption coefficient in the sub-band gap region was found, indicating the high optical quality of all three crystals. We extracted the band gap values through critical point analysis showing that Tauc-based values are systematically underestimated. The two structural phase transitions, i.e., orthorhombic-tetragonal and tetragonal-cubic, show distinct optical behaviors, with the former having a discontinuous character. The cross-correlation of optical data with DFT calculations evidences the role of octahedral tilting in tailoring the value of the band gap at a given temperature, whereas differences in the thermal expansion affect the slope of the band gap trend as a function of temperature.
Introduction of functional groups into polymer films via deep-UV photolysis or electron-beam lithography: modification of polystyrene and poly(3-octylthiophene) by a functionalized perfluorophenyl azide (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIntroduction of functional groups into polymer films via deep-UV photolysis or electron-beam lithography: modification of polystyrene and poly(3-octylthiophene) by a functionalized perfluorophenyl azideSui Xiong Cai, Manoj Kanskar, M. N. Wybourne, and John F. W. KeanaCite this: Chem. Mater. 1992, 4, 4, 879–884Publication Date (Print):July 1, 1992Publication History Published online1 May 2002Published inissue 1 July 1992https://pubs.acs.org/doi/10.1021/cm00022a025https://doi.org/10.1021/cm00022a025research-articleACS PublicationsRequest reuse permissionsArticle Views207Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts