gebhart/patrepeval huggingface dataset:
Performance and Dependability Modeling of Dynamic Systems (2011)

Triple-negative breast cancer (TNBC) is one of the most malignant cancers associated with early metastasis, poor clinical prognosis, and high recurrence rate. TNBC is a distinct subtype of breast cancer that lacks estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 receptors (HER2). Development of effective TNBC therapies has been limited partially due to the lack of specific molecular targets and chemotherapy involving different cytotoxic drugs suffers from significant side effects and drug-resistance development. Therefore, there is an unmet need for the development of novel and efficient therapeutic drugs with reduced side effects to treat TNBC. We have previously reported that certain analogues of haloperidol (a typical antipsychotic drug used for treating mental/mood disorders such as schizophrenia and bipolar disorder) suppress the viability of a variety of solid tumor cell lines, and we have identified 4-(4-(4-chlorophenyl)-1,4-diazepan-1-yl)-1-(4-fluoro-phenyl)butan-1-one (SYA013) with such antiproliferative properties. Interestingly, unlike haloperidol, SYA013 shows moderate selectivity toward σ<sub>2</sub> receptors. In this study, we explored the potential of SYA013 in modulating the important biological events associated with cell survival and progression as well as the mechanistic aspects of apoptosis in a representative TNBC cell line (MDA-MB-231). Our results indicate that SYA013 inhibits the proliferation of MDA-MB-231 cells in a concentration-dependent manner and suppresses cell migration and invasion. Apoptotic studies were also conducted in MDA-MB-468 cells (cells derived from a 51-year old Black female with metastatic adenocarcinoma of the breast.). In addition, we have demonstrated that SYA013 induces MDA-MB-231 cell death through the intrinsic apoptotic pathway and may suppress tumor progression and metastasis. Taken together, our study presents a mechanistic pathway of the anticancer properties of SYA013 against TNBC cell lines and suggests a potential for exploring SYA013 as a lead agent for development against TNBC.
A thermomechanical framework of plasticity based on probabilistic micromechanics (2008)

A conventional thermomechanical elasto-plastic constitutive modelling framework is proposed but which allows an effective physical interpretation of the micromechanical internal variables and inherent parameters in a representative volume element (RVE).The statistical distribution of the elastic-plastic parameters within the RVE is described using a simple statistical method of probabilistic rearrangement (MPR).This method facilitates deriving analytical approximating formulas to the stress-strain response of the RVE under unidirectional monotonic loading conditions.The applicability of the MPR is validated numerically by comparing the analytical formulas against numerical experiments of a probabilistic boundary value problem initially under monotonic conditions.The assumptions associated with the MPR are embedded within the simple micro thermomechanical constitutive framework and further evaluated numerically by applying the methodology for the case of cyclic loads.For the limited experimental program the constitutive modelling framework seems to give a rather effective estimation of the full boundary value problem.The results for the cyclic case demonstrate how hysteresis behaviour of materials could be modelled without incorporating kinematic hardening parameters.
Rainforest Endophytes and Bioactive Products (2002)

An increase in the number of people in the world having health problems caused by certain cancers, drug-resistant bacteria, parasitic protozoans, and fungi has caused alarm. An intensive search for newer and more effective agents to deal with these problems is now underway. Endophytes are a potential source of novel chemistry and biology to assist in helping solve not only human health, but plant and animal health problems also. Endophytes reside in the tissues between living plant cells. The relationship that they establish with the plant varies from symbiotic to bordering on pathogenic. Of all of the world's plants, it seems that only a few grass species have had their complete complement of endophytes studied. As a result, the opportunity to find new and interesting endophytes among the myriad of plants is great. Sometimes extremely unusual and valuable organic substances are produced by these endophytes. These compounds may contribute to the host-microbe relationship. The initial step in dealing with endophytic microorganisms is their successful isolation from plant materials. Then, the isolation and characterization of bioactive substances from culture filtrates is done using bioassay guided fractionation and spectroscopic methods. Some of the more interesting compounds produced by endophytic microbes with which we have dealt are taxol, cryptocin, cryptocandin, jesterone, oocydin, isopestacin, the pseudomycins and ambuic acid. This review discusses an approach for bio-prospecting the rainforests, not only to harvest their endophytic microorganisms, but to eventually build a better understanding of the importance and value they have to humankind.
Investigation of Size-Dependent Vibration Behavior of Piezoelectric Composite Nanobeams Embedded in an Elastic Foundation Considering Flexoelectricity Effects (2023)

This article investigates the size dependent on piezoelectrically layered perforated nanobeams embedded in an elastic foundation considering the material Poisson’s ratio and the flexoelectricity effects. The composite beam is composed of a regularly squared cut-out elastic core with two piezoelectric face sheet layers. An analytical geometrical model is adopted to obtain the equivalent geometrical variables of the perforated core. To capture the Poisson’s ratio effect, the three-dimensional continuum mechanics adopted to express the kinematics are kinetics relations in the framework of the Euler–Bernoulli beam theory (EBBT). The nonlocal strain gradient theory is utilized to incorporate the size-dependent electromechanical effects. The Hamilton principle is applied to derive the nonclassical electromechanical dynamic equation of motion with flexoelectricity impact. A closed form solution for resonant frequencies is obtained. Numerical results explored the impacts of geometrical and material characteristics on the nonclassical electromechanical behavior of nanobeams. Obtained results revealed the significant effects of the mechanical, electrical, and elastic foundation parameters on the dynamic behavior of piezoelectric composite nanobeams. The developed procedure and the obtained results are helpful for many industrial purposes and engineering applications, such as micro/nano-electromechanical systems (MEMS) and NEMS.
[Inhibitory effect of Adp53 and F56 on growth and metastasis of transplantation of the breast tumor in mice]. (2007)

Adp53 combined with F56 can greatly inhibit growth and metastasis of breast cancer in vivo. The mechanism of anti-tumor effects of Adp53 and F56 may be related to the anti-angiogenesis effect on malignant tumor through inhibiting the expression and activity of VEGF.
Sliding Mode Control of Magnetic Bearings: a Hardware Perspective (1999)

The physical hardware of magnetic bearing systems has a very strong impact on the application of sliding mode control to this technology. Finite current slew rates affect the character of achievable reaching conditions; flexible rotors demand the use of state observers which then affect achievable robustness; finite controller throughput and use of switching power amplifiers has substantial impact on how chatter should be addressed. This paper formulates the sliding mode control problem for realistic rotor/magnetic actuator systems considering rotor flexibility and finite amplifier voltages. The structure of the resulting class of controllers is examined for both rigid and for flexible rotors. It is demonstrated that, fundamentally, these controllers are conventional linear state observer based controllers acting through high speed switching amplifiers as in conventional magnetic bearing technology.
Lung Cancer: Solitary Pulmonary Nodule (2022)

A 55-year old, middle-aged man, known for hypertension and dyslipidemia, presented to the OPD with complaints of fever along with a mild dry cough. There was no shortness of breath or chest pain associated with the patient’s complaints. Therefore, as a seemingly obvious diagnosis, he was suspected of having a COVID-19 infection. &#x0D; The man has a positive smoking history of approximately 20 cigarettes per day for 25 years. However, his COVID-19 PCR tests provided two negative results. His chest X-ray was also unremarkable. Apart from some abnormalities in his laboratory analyses, which have been discussed in detail in the coming sections, there seemed to be nothing unusual or out of place with the patient.&#x0D; However, when a CT scan without contrast was ordered for the patient, the report showed a mass that was approximately 23 x 21 x 16 mm in size. The mass had a soft, tissue-like consistency. It also appeared to have irregular, lobulated margins. This entire mass was seen to be present in the anterior segment of the upper lobe of the left lung.&#x0D; Apart from this mass, no COVID-19-related consolidations or signs of respiratory distress were seen in this patient.&#x0D; When the mass was confirmed, a needle-core biopsy was done to find out the nature of it. The biopsy report confirmed that the mass was indeed a moderate-to-poorly differentiated non-small cell carcinoma of the lung, which was consistent with adenocarcinoma with sarcomatoid features. All these aspects of the tumor, with radiological evidence, have been discussed below.&#x0D; The patient is being supportively managed as of now and is also being kept on a follow-up schedule.&#x0D; What's worth mentioning, however, is that despite such minor symptoms, the underlying problem could still be serious. If the patient had not gone for an X-ray or CT for their suspected COVID-19 abnormalities, then their case would not have come to a diagnosis and it would have eventually taken a turn for the worse. The whole case, along with the findings and the patient response has been discussed throughout this paper.
Der 5-HT2A-Rezeptor moduliert die motorisch/exploratorische Aktivität und die nigrostriatale und mesolimbische D2-Rezeptorbindung bei der Ratte (2022)

Ziel/Aim 2,5-Dimethoxy-4-iodoamphetamin (DOI) und Altanserin (ALT) wirken als 5-HT2A-Rezeptor(R)-Agonist bzw. -Antagonist. In dieser Studie untersuchten wir die Wirkung von akut verabreichtem DOI und ALT auf das motorisch/exploratorische Verhalten und die D2R-Bindung im Gehirn der Ratte.
Blood pressure measurements with foil electret transducer (1980)

We have designed a Korotkov (K)-sound Foil Electret transducer for use in an automatic blood pressure monitoring system. Systolic and diastolic pressures, were measured at the normal brachial artery location using a cuff technique. Two modifications of the wide band foil electret microphone, normally used for airborne sounds, were necessary to create the K-sound detector. These were (1) to a thicker diaphragm 50 to 75 μm was used in place of the usual 12 to 25 μm diaphragm, (2) multiple ridges spaced 5 mm apart and with heights comparable to the foil thickness were built into the back plate. These changes plus appropriate filtering result in a transducer with uniform sensitivity over the frequency range from 1–60 Hz. There are two major advantages of this system over previously used transducers: (1) Its sensitivity is higher by a factor of at least 50. (2) Its positioning over the artery is not as critical as other designs because its sensitivity is independent of the diaphragm excitation point. These advantages give better K-sound detection capabilities and more accurate blood pressure determinations.
Non-fluoroscopic mapping systems for electrophysiology: the ‘tool or toy’ dilemma after 10 yearsThe opinions expressed in this article are not necessarily those of the Editors of the European Heart Journal or of the European Society of Cardiology. (2006)

Searching in PubMed for the string ‘tool or toy’ in the title of medical papers, we found that over the past three decades about 50 papers brought up the dilemma concerning whether a novel technology is a useful tool, or merely an expensive toy. The papers are from 15 different medical disciplines spanning from radiology, neurology, anaesthesia, and surgery. Surprisingly, in almost half of these papers the ‘tool or toy’ dilemma is posed for new technologies introduced in the cardiovascular field. Several of them, such as stress echocardiography and transoesophageal echocardiography, have become widely diffused and have definitely become routine practice. Although this analysis of the medical literature is gross, the result underlines that this dilemma is not so rare. In fact, new technologies are periodically proposed and the reaction of the medical community is usually quite ambiguous, varying from the hardest scepticism to the warmest enthusiasm. Actually, far from being an expression of physicians' uncertainty, the dilemma is justified by the fact that on one hand new technologies, especially in their early phases, are associated with high costs for equipment acquisition and their disposable parts, that the field of application is not well defined, and that the initial version is usually not completely developed because the engineer's work requires physician's feedback to ameliorate and render user friendly, brand new technologies. On the other hand, the introduction of new technologies may be the first step in a revolution which advances the frontiers of medical science and therapeutic approaches by providing more effective treatments in an always increasing cohort of patients.

In 1996, the in vivo use of a non-fluoroscopic magnetic technology for endocardial navigation and mapping of the heart was reported.1 Although initially the focus was on the fact that the position of the catheter could be … 

*Corresponding author. Tel: +39 0332 278934; fax: +39 0332 393309. E-mail address : rdeponti{at}alice.it
T-cell receptor beta chain gene rearrangement in acute myeloid leukemia always occurs at the allele that contains the undermethylated J beta 1 region. (1992)

The epigenetic phenomenon could play a role in the interaction between chromatin and DNA-binding enzymes, allowing us to consider an association between the phenomenon and gene rearrangement. The correlation between methylation status and rearrangement of the T-cell receptor (TCR) beta chain gene in leukemia cells obtained from patients with acute myeloid leukemia (AML) was examined. All of the AML patients with a TCR-beta rearrangement had hypomethylated CCGG sequences within the J beta 1 region on the rearranged allele, while the germline allele had completely methylated CCmeGG sequence in this region, indicating a strong association between hypomethylation status and rearrangement of the TCR beta chain gene. In the DNA from AML patients with or without a TCR-beta rearrangement, the C beta 2 region contained completely methylated CCmeGG sequences, even though they express T-cell-associated antigens, including CD7; this pattern is quite different from that observed in T-cell neoplasias. Moreover, some AML patients showed a TCR-beta rearrangement without the presence of immunoglobulin heavy-chain gene rearrangement, suggesting that TCR beta chain gene involvement in AML is required for unknown factors other than common recombinase activity.
Métamorphoses du Roman Policier dans Archéologie du Chaos ( Amoureux ) de Mustapha Benfodil (2014)

Dans son entreprise de legitimation et de hierarchisation des genres, la critique litteraire n’a pas epargne le roman policier de ses sentences virulentes. En effet, le polar a ete longtemps considere comme un « mauvais genre [i] » faisant partie de la paralitterature, plus exactement de la litterature « Noire [ii] », par opposition a la litterature generale  « Blanche [iii] ». Ce mepris que recouvre ce genre est sans doute lie a la sclerose qui entoure sa conception, a savoir un enjeu qui tient en un seul mot, celui de «  methode qui est rationnelle, positive, voire scientifique [iv] ». Cette obsession de verite qui se materialise a travers l’enquete, infecte profondement le texte qui devient une structure fonctionnelle et fermee. C’est en raison de cette rigidite, manque de poesie et pauvrete de la langue que le recit policier a ete considere comme un genre fortement codifie, et que son statut generique s’est vu enferme dans le ghetto de la sous-litterature. Cette soumission aux conventions fait du roman policier un texte determine par un ensemble de traits stereotypes et figes : la predominance du narratif, le recours aux cliches, les figures folkloriques stereotypees (trafiquants, gigolos, maquerelles, caids, indicateurs) etc. [i] - Denis MELLIER et Gilles MENEGALDO, Formes policieres du roman contemporain , Poitier, La Licorne, 1998, p.04 . [ii] - Franck EVRARD, Lire le roman policier , Paris, Dino, 1996, p. 72. [iii] - IBID . p. 56. [iv] - Dominique MEYER-BOLZINGER, «  Le savoir en suspens » , La Magazine litteraire , N. 519, Mai 2012, pp. 50- 51.
Proteins of the Golgi apparatus (1993)

The Golgi marker enzyme, UDP-galactose:N-acetylglucosamine beta 1-4galactosyltransferase (beta 1-4GalT) was purified 44300-fold in its intact, membrane-bound form from rat liver membranes. The protein was isolated from detergent extracts as a high-M(r) form, having a Stokes radius approximating a globular protein of M(r) 440,000. It is comprised of a single protein component as observed on SDS/polyacrylamide gels, having an M(r) near 51,000, and does not have intermolecular disulfide cross-links. N-terminal sequencing of the enzyme demonstrated that it contains an N-terminal hydrophobic stretch deduced previously from cDNA encoding for the enzyme. Previous studies have indicated that the protein may be translated at either of two AUG sites near the 5' end of the mRNA [Russo, R. N., Shaper, N. L. & Shaper, J. H. (1990) J. Biol. Chem. 265, 3324-3331], giving rise to two polypeptides, one appended with 13 amino acids. In the work described here, evidence was only found for the sequence of the short form, missing a single methionine at the N-terminus. Mild proteolytic treatment cleaved the enzyme, giving rise to low-M(r) forms which were fully catalytically active and which, upon sequencing, were missing a 66-amino-acid stretch from the N-terminus (as compared to the mouse cDNA). Proteolytic treatment was accompanied by conversion of the form having a large Stokes radius to one approximating a globular protein with M(r) near 50,000. The N-terminal stretch appears to contribute to maintenance of the form having a large Stokes radius. This may be the result of interaction with a detergent micelle, dimerization or oligomerization, or interaction with some other large, non-protein molecule, although a detergent exchange still resulted in a form having a large Stokes radius.
Offline Configuration Resources about Smart Substation Multi-Dimensional and Multi-Objective Customization and Information Merger (2014)

Offline Configuration Resources about Smart substation Multi-dimensional and multi-objective customization and information merger is an important means of the development for the large-scale grid operation. In this paper, the method of smart substation model customization and information merger for multi-level control center is proposed. This paper puts forward the scheme、data flow and key technologies of model customization and information merger. The software of model customization and information merger, which can flexibly configure the rule of model reduction and information merger according to different scenarios, is designed and developed. The software is validated in the laboratory, which illustrates that idea of this paper has good potential value.
Antileishmanial Carbasugars from Geosmithia langdonii (2018)

Two new carbasugar-type metabolites, (1 S,2 R,3 R,4 R,5 R)-2,3,4-trihydroxy-5-methylcyclohexyl-2',5'-dihydroxybenzoate (1) and (1 S,2 S,3 S,4 R,5 R)-4-[(2',5'-dihydroxybenzyl)oxy]-5-methylcyclohexane-1,2,3-triol (2), were isolated from the filamentous fungus Geosmithia langdonii isolated from cotton textiles from Assiut, Egypt. The structures of 1 and 2 were elucidated based on comprehensive 1D and 2D NMR and MS data. Compounds 1 and 2 showed antileishmanial activity against Leishmania donovani with IC<sub>50</sub> values of 100 and 57 μM, respectively. The (1 S,2 R,3 R,4 R,5 R) absolute configuration of carbasugar 1 was assigned via 2D NMR and experimental and calculated electronic circular dichroism (ECD) data. Similarly, the tentative structure of compound 2 was shown to possess a (1 S,2 S,3 S,4 R,5 R) absolute configuration via comparing its experimental ECD data and the specific rotation with 1 as well as examining the energy-minimized 3D computational models of compounds 1 and 2.
IEEE 802.11p based physical layer simulator for Car-to-Car communication (2011)

For a well working Car-to-Car (C2C) communication system the handling of the radio channel is a challenging task. The fast changing environment as a result of a time variant behavior of the channel, and the antennas, are the two most important factors influencing the C2C transmission channel. To analyze the impact of both on the performance of such a communication system is a difficult task. A possible solution is to employ a simulation-based evaluation. In this paper a physical layer simulator, based on IEEE 802.11p, is presented. For the channel modeling a 3D ray-tracing tool including a realistic traffic model is used. Besides the simulation approach, measurements results for C2C communications are provided.
Study on 28 cases with memorrhagic salpingitis (2000)

Objective: To explore the causes of misdiagnosis about salpingitis Methods: The data of history and clinical manifestaitions, blood routine examinations and B ultrasonic diagnosis apparatus, and pathological examination after operation were used ReSults: 28 cases were all misdiagnosed as ectopic pregnancy or rupture of ovary, whith were related with insufficient knowledge about the disease Conclusion: Hemorrhagic salpingitis is readily misdignosed Identifications should be enforced in order to derease the misdiagnosis rate in clinical practice.
Photochemistry of Ru(bpy)2(dcbpy)2+ on Al2O3 and TiO2 Surfaces. An Insight into the Mechanism of Photosensitization (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotochemistry of Ru(bpy)2(dcbpy)2+ on Al2O3 and TiO2 Surfaces. An Insight into the Mechanism of PhotosensitizationK. Vinodgopal, Xiao Hua, Robin L. Dahlgren, A. G. Lappin, L. K. Patterson, and Prashant V. KamatCite this: J. Phys. Chem. 1995, 99, 27, 10883–10889Publication Date (Print):July 1, 1995Publication History Published online1 May 2002Published inissue 1 July 1995https://pubs.acs.org/doi/10.1021/j100027a032https://doi.org/10.1021/j100027a032research-articleACS PublicationsRequest reuse permissionsArticle Views1114Altmetric-Citations137LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts