gebhart/patrepeval huggingface dataset:
Short-Circuit Ruggedness and Partial Discharge Evaluation of a 3.3 kV SiC MOSFET Power Module (2022)

This paper presents the initial evaluation of a 3.3-kV, SiC MOSFET power module (not fully populated) from Wolfspeed, including static, short circuit (SC), and partial discharge (PD) test results. Static characterization results are presented first. The module performance change after repetitive pulse SC tests is provided by comparing the original static characterization test results to the one performed after the SC stress tests. More electric aircrafts (MEA) require an increased electric system voltage level (e.g., 230 VAC constant or variable frequency, ± 270 VDC or 540 VDC) and make PD a very relevant and urgent issue. Thus, PD evaluation tests for the module package are included for different air pressures from Sea Level (i.e., 760 Torr) to 50,000 feet (i.e., 87 Torr) altitude. The PD inception voltage (PDIV) and extinction voltage (PDEV) obtained via experimentation are presented in this paper.
Enhancing the Deformation of Shape Memory Sandwich Panels (2010)

Abstract: Composite sandwich panels fabricated using a thermosetting shape memory polymer matrix material and a corresponding thermoset shape memory polymer foam core offer the potential to demonstrate large, recoverable, deformations in otherwise stiff structures, under flexural loading. However, as with flexure of thin, fibre‐reinforced shape memory matrix laminates, deflection is limited by fibre compression buckling because of the reduced shape memory matrix stiffness at elevated temperature. A hybrid matrix concept has been developed for sandwich panels loaded in flexure in a single direction. This concept uses a non‐shape memory resin as the matrix for a fraction of the plies on the surface of the facesheet loaded in compression. It is predicted that, at the elevated temperatures required for the generation of deformation in the shape memory structural sandwich panel, the shape memory matrix and foam moduli will be substantially reduced, while the modulus of the non‐shape memory resin will not. Thus, at elevated temperature this effectively leads to a shift of the neutral axis towards the non‐shape memory surface, keeping the low stiffness shape memory matrix material in tension and extending the range of deformation prior to onset of fibre buckling. The experiments performed demonstrate that this hybrid matrix approach enables a three‐fold increase in mid‐span deformation prior to buckling of fibres in the compression surface plies. Furthermore, the force measured to attain the deformed geometry, at elevated temperature, only increases approximately 10–15%, while the magnitude of the force required remains very low. Thus, the hybrid matrix approach functions as predicted and enables the development of sandwich panel structural elements which can undergo large, recoverable deformations.
Expression of the c-myc Proto-oncogene Is Essential for HIV-1 Infection in Activated T Cells (1999)

We previously found that activation of primary CD4+ T cells via both the T cell antigen receptor (TCR) and CD28 is required for HIV-1 DNA to be translocated from the cytoplasm to the nucleus. Here we report that expression of c-Myc protein in CD4+ T cells is induced only after such costimulation. In addition, cyclosporin A not only inhibits nuclear import of HIV-1 DNA but also inhibits expression of c-Myc protein. Because of these correlations, we tested whether c-Myc is necessary for nuclear import of HIV-1 DNA. Specific c-myc antisense, but not sense or non-sense, phosphorothioate oligodeoxynucleotides selectively induced the accumulation of two NH2-terminally truncated c-Myc proteins and abolished HIV-1 genome entry into host nuclei. Consequently, both virus replication and HIV-1-induced apoptotic cell death were inhibited. Synthesis of viral full-length DNA was not affected. Specific c-myc antisense oligonucleotide inhibited HIV-1 infection under conditions that did not affect cell cycle entry or proliferation. Thus, c-Myc appears to regulate HIV-1 DNA nuclear import via a mechanism distinct from those controlling entry into the cell cycle.
Copper and Iron Disorders of the Brain (2007)

Copper and iron are transition elements essential for life. These metals are required to maintain the brain's biochemistry such that deficiency or excess of either copper or iron results in central nervous system disease. This review focuses on the inherited disorders in humans that directly affect copper or iron homeostasis in the brain. Elucidation of the molecular genetic basis of these rare disorders has provided insight into the mechanisms of copper and iron acquisition, trafficking, storage, and excretion in the brain. This knowledge permits a greater understanding of copper and iron roles in neurobiology and neurologic disease and may allow for the development of therapeutic approaches where aberrant metal homeostasis is implicated in disease pathogenesis.
Multiple Organ Dysfunction Syndrome in Bone Marrow Transplantation (1995)

Single organ dysfunction during BMT is a marker for a systemic abnormality that has a high likelihood of progressing to MODS, similar to that seen in other critically ill patient populations. MODS is the leading cause of death in series of BMT patients. Low levels of ATIII and PC are markers of and may be involved in the pathogenesis of MODS in BMT.
A highly divergent mitochondrial genome in extant Cape buffalo from Addo Elephant National Park, South Africa (2023)

Abstract The reduced cost of next-generation sequencing (NGS) has allowed researchers to generate nuclear and mitochondrial genome data to gain deeper insights into the phylogeography, evolutionary history, and biology of non-model species. While the Cape buffalo ( Syncerus caffer caffer ) has been well-studied across its range with traditional genetic markers over the last 25 years, researchers are building on this knowledge by generating whole genome, population-level data sets to improve understanding of the genetic composition and evolutionary history of the species. Using publicly available NGS data, we assembled 40 Cape buffalo mitochondrial genomes (mitogenomes) from four protected areas in South Africa, expanding the geographical range and almost doubling the number of mitogenomes available for this species. Coverage of the mitogenomes ranged from 154-1,036X. Haplotype and nucleotide diversity for Kruger National Park (n = 15) and Mokala National Park (n = 5) were similar to diversity levels in southern and eastern Africa. Hluhluwe-iMfolozi Park (n = 15) had low levels of genetic diversity, with only four haplotypes detected, reflecting its past bottleneck. Addo Elephant National Park (n = 5) had the highest nucleotide diversity of all populations across Africa, which was unexpected, as it is known from previous studies to have low nuclear diversity. This diversity was driven by a highly divergent mitogenome from one sample, which was subsequently identified in another sample via Sanger sequencing of the cytochrome b gene. Using a fossil-calibrated phylogenetic analysis, we estimated that this lineage diverged from all other Cape buffalo lineages approximately 2.51 million years ago. We discuss several potential sources of this mitogenome but propose that it most likely originated through introgressive hybridisation with an extinct buffalo species, either S. acoelotus or S. antiquus . We conclude by discussing the conservation consequences of this finding for the Addo Elephant National Park population, proposing careful genetic management to prevent inbreeding depression while maintaining this highly unique diversity.
A phase I-II study of continuous 5-day infusion mitomycin-C (1983)

A phase I-II study was undertaken to establish the maximum-tolerated dose of a continuous 5-day infusion of mitomycin-C and its efficacy in patients with advanced metastatic drug-resistant breast and gastrointestinal malignancies. The dose-limiting toxicity was myelosuppression, predominantly thrombocytopenia, and was severe and cumulative. Nonhematologic toxicity was infrequent, and no renal or cardiac toxicity was seen. For patients with breast cancer who had received extensive prior therapy, 3 mg/m2/day for 5 days repeated every 6-8 weeks were well-tolerated doses; and for patients with gastrointestinal cancer, the maximum-tolerated dose was 4 mg/m2/day. One patient with breast cancer had a partial response lasting 4 months, and no responses were observed in patients with gastrointestinal cancer. The administration of mitomycin-C by continuous infusion did not appear to have improved its therapeutic index.
Disruption of the Candida albicans TPS2 Gene Encoding Trehalose-6-Phosphate Phosphatase Decreases Infectivity without Affecting Hypha Formation (2002)

Deletion of trehalose-6-phosphate phosphatase, encoded by TPS2, in Saccharomyces cerevisiae results in accumulation of trehalose-6-phosphate (Tre6P) instead of trehalose under stress conditions. Since trehalose is an important stress protectant and Tre6P accumulation is toxic, we have investigated whether Tre6P phosphatase could be a useful target for antifungals in Candida albicans. We have cloned the C. albicans TPS2 (CaTPS2) gene and constructed heterozygous and homozygous deletion strains. As in S. cerevisiae, complete inactivation of Tre6P phosphatase in C. albicans results in 50-fold hyperaccumulation of Tre6P, thermosensitivity, and rapid death of the cells after a few hours at 44 degrees C. As opposed to inactivation of Tre6P synthase by deletion of CaTPS1, deletion of CaTPS2 does not affect hypha formation on a solid glucose-containing medium. In spite of this, virulence of the homozygous deletion mutant is strongly reduced in a mouse model of systemic infection. The pathogenicity of the heterozygous deletion mutant is similar to that of the wild-type strain. CaTPS2 is a new example of a gene not required for growth under standard conditions but required for pathogenicity in a host. Our results suggest that Tre6P phosphatase may serve as a potential target for antifungal drugs. Neither Tre6P phosphatase nor its substrate is present in mammals, and assay of the enzymes is simple and easily automated for high-throughput screening.
Development of wastewater treatment in the Pearl Delta: a balancing act (1999)

This paper reviews the current state of water pollution in the Pearl Delta, highlights the main problems, and discusses how private participation may serve a catalytic function in the important task of preventing the world's biggest economic boom turning into an environmental disaster.
Neuronally derived extracellular vesicles: an emerging tool for understanding Alzheimer’s disease (2019)

In order for Alzheimer's disease (AD) to manifest, cells must communicate "pathogenic material" such as proteins, signaling molecules, or genetic material to ensue disease propagation. Small extracellular vesicles are produced via the endocytic pathways and released by nearly all cell types, including neurons. Due to their intrinsic interrelationship with endocytic processes and autophagy, there has been increased interest in studying the role of these neuronally-derived extracellular vesicles (NDEVs) in the propagation of AD. Pathologic cargo associated with AD have been found in a number of studies, and NDEVs have been shown to induce pathogenesis in vivo and in vitro. Exogenous NDEVs are also shown to reduce plaque burden in AD models. Thus, the NDEV has the potential to become a useful biomarker, a pathologic potentiator, and a therapeutic opportunity. While the field of NDEV research in AD is still in its infancy, we review the current literature supporting these three claims.
Novel Synthesis of 5-(Arylimino)-4-(dialkylamino)-5H-1,2,3-dithiazoles and the Mechanism of Their Formation (1994)

The reactions of 5-(arylimino)-4-chloro-5H-1,2,3-dithiazo 1 with excess (6 equiv) bulky dialkylamines such as diethyl-, di-n-propyl-, and di-n-butylamines in CH2Cl2 at room temperature gave 5-(arylimino)-4-(dialkylamino)-5H-1,2,3-dithiazoles 5 in 18-76% yields. Compounds 5 are formed via (arylimino)cyanomethyl alkylamino disulfides 3. Nucleophilic addition of the amines to the carbon atom of the cyano group of 3 and subsequent cyclization afford 5.
Prediction of coke strength for coal blend control (1983)

A new approach is shown to predict coke strength (DI/SUP/3/SUP/O/SUB/1/SUB/5) from coal quality and working conditions. Theoretical consideration of the coking process and DI/sup 30//sub 15/ shows that: (1) tensile strength of semi-coke and thermal stress generated in semi-coke are factors affecting DI/sup 30//sub 15/; and (2) each factor is expressed by petrographic parameters derived from fluidity and the volatile matter of coal, the degree of crushing of the charge, the flue temperature in the coke oven, and the inhomogeneity of the charge. An equation for predicting DI/sup 30//sub 15/ is constructed in a general form on the basis of these considerations. In practice, each coefficient in the equation is determined by data analysis. Because of its accuracy and simplicity, the equation is being used at coke works.
Effect of thoracic stiffness on chest compression performance - A prospective randomized crossover observational manikin study (2022)

The thoracic stiffness greatly affected the performance of ECC. Our findings provided information for more effective ECC practices and training.
Improved MicroED structures by cryo-FIB milling (2020)

Microcrystal electron diffraction is an electron cryo-microscopy method that determines crystal structures from vanishingly small crystals. The strong interaction between high energy electrons and matter limits the size of crystals to those typically thinner than perhaps 500 nanometers. Though some crystals will naturally form crystals small enough for MicroED, many will end up too large for MicroED and too small for synchrotron X-ray diffraction experiments. We demonstrate the combination of scanning electron microscopy (SEM) and cryogenic focused ion-beam (FIB) milling of protein microcrystals. Our approach results in ideally thick specimens with better crystallographic statistics, and opens MicroED to entirely new experiments. Here, we present the methods, rationale, and recent results using this approach.
Radioactivity measurement of Sr/Y-90 mixed with Cs-134 and Cs-137 using large solid angle detectors without chemical separation (2014)

We proposed a method to measure the radioactivity of Sr/Y-90 in the mixture of Cs-134 and Cs-137 without chemical pretreatment. It was realized by subtracting the electrons produced in Cs-134 and Cs-137 from entire electron emission rate that can be determined by the efficiency tracer technique in the 4πβ–γ coincidence counting method. The radioactivity of Cs-134 and Cs-137 can be determined by gamma ray spectrometry. The measurements were conducted using plastic and NaI(Tl) scintillation detector with a large solid angle. The validity of the measurement method was shown by agreement of the results with the known radioactivities.
Resistance mechanism to Notch inhibition and combination therapy in human T cell acute lymphoblastic leukemia (2022)

Abstract Gain-of-function mutations in NOTCH1 are among the most frequent genetic alterations in T cell acute lymphoblastic leukemia (T-ALL), making the Notch signaling pathway a promising therapeutic target for personalized medicine. Yet, a major limitation for long-term success of targeted therapy is relapse due to tumor heterogeneity or acquired resistance. Thus, we performed a genome-wide CRISPR-Cas9 screen to identify prospective resistance mechanisms to pharmacological NOTCH inhibitors and novel targeted combination therapies to efficiently combat T-ALL. Mutational loss of Phosphoinositide-3-Kinase regulatory subunit 1 (PIK3R1) causes resistance to Notch inhibition. PIK3R1 deficiency leads to increased PIK3/Akt signaling which regulates the cell cycle and spliceosome machinery, both at the transcriptional and post-translational level. Moreover, several therapeutic combinations have been identified, where simultaneous targeting of the cyclin-dependent kinases 4 and 6 (CDK4/6) and NOTCH proved to be the most efficacious in T-ALL xenotransplantation models. Key points Mutational loss of PIK3R1 induces resistance to NOTCH1 inhibition in T-ALL Pharmacological Notch inhibition synergizes with CDK4/6 inhibitors in T-ALL
Quantitative and Qualitative Gender Differences in the Immune System may Contribute to the Mild Progression of HCV Infection in Women (2004)

Background: HCV infection has progressed slowly in the female chort of patients infected through Anti-D. There is evidence to suggest that the disease is more aggressive in males.
Study on Reattachment in Axisymmetric Laminar Lifted Flames (2000)

Reattachment characteristics of laminar flames in partially premixed jets are studied for propane fuel mixed with air. As the flow rate decreases, liftoff height is decreased nonlinearly and the flame reattaches to a nozzle at a certain liftoff height. Using a jet theory by taking into account a virtual origin, it is predicted that flow velocity along a stoichiometric contour has a maximum value near nozzle. With this velocity characteristics, it is shown that reattachment mechanism can be explained by a balance between flame speed and flow velocity. Predicted displacement speeds at reattachment and liftoff agree qualitatively well with experimental findings.
LRP: a bright beacon at the blood-brain barrier (2003)

Ever more unexpected roles for the LDL receptor gene family in a variety of cellular signaling pathways continue to emerge. Three recent studies now add another function to this collection. By interacting with active tissue-type plasminogen activator, LDL receptor–related protein appears to control permeability of the blood-brain barrier, vascular tone, and the expression of MMPs. All of these parameters impact upon postischemic infarct size following stroke. These novel findings are discussed in the context of known mechanisms of signaling by the LDL receptor family.
Discovery of 1,2,3-Triazole Derivatives for Multimodality PET/CT/Cryoimaging of Myelination in the Central Nervous System (2017)

Myelin pathology is present in many neurological conditions such as multiple sclerosis (MS) and traumatic spinal cord injury (SCI). To facilitate development of novel therapies aimed at myelin repair, we set out to develop imaging agents that permit direct quantification of myelination in vivo. In this work, we designed and synthesized a series of fluorescent fluorinated myelin imaging agents that can be used for in vivo positron emission tomography (PET) imaging combined with subsequent post-mortem fluorescent cryoimaging. Structure-activity relationship (SAR) studies of the newly developed myelin imaging agents led us to identify a lead compound (TAFDAS, 21) that readily enters the brain and spinal cord and selectively binds to myelin. By conducting sequential PET and 3D cryoimaging in an SCI rat model, we demonstrated for the first time that PET and cryoimaging can be combined as a novel technique to image the spinal cord with high sensitivity and spatial resolution.
Tracheal occlusion-evoked respiratory load compensation and inhibitory neurotransmitter expression in rats (2014)

Respiratory load compensation is a sensory-motor reflex generated in the brain stem respiratory neural network. The nucleus of the solitary tract (NTS) is thought to be the primary structure to process the respiratory load-related afferent activity and contribute to the modification of the breathing pattern by sending efferent projections to other structures in the brain stem respiratory neural network. The sensory pathway and motor responses of respiratory load compensation have been studied extensively; however, the mechanism of neurogenesis of load compensation is still unknown. A variety of studies has shown that inhibitory interconnections among the brain stem respiratory groups play critical roles for the genesis of respiratory rhythm and pattern. The purpose of this study was to examine whether inhibitory glycinergic neurons in the NTS were activated by external and transient tracheal occlusions (ETTO) in anesthetized animals. The results showed that ETTO produced load compensation responses with increased inspiratory, expiratory, and total breath time, as well as elevated activation of inhibitory glycinergic neurons in the caudal NTS (cNTS) and intermediate NTS (iNTS). Vagotomized animals receiving transient respiratory loads did not exhibit these load compensation responses. In addition, vagotomy significantly reduced the activation of inhibitory glycinergic neurons in the cNTS and iNTS. The results suggest that these activated inhibitory glycinergic neurons in the NTS might be essential for the neurogenesis of load compensation responses in anesthetized animals.
Storm- and eddy-resolving simulations with IFS-FESOM/NEMO at the kilometre scale (2023)

Global coupled simulations that can resolve atmospheric storms and mesoscale oceanic features at the kilometre-scale have recently become possible to run over short time slices, for example on a seasonal timescale. Here we give an overview of the first multi-year simulations performed with ECMWF&amp;#8217;s Integrated Forecasting System (IFS), coupled to both the NEMO and FESOM2 ocean-sea ice models, for the H2020 Next Generation Earth Modelling Systems (nextGEMS) project. The project aims to build a new generation of eddy- and storm-resolving global coupled Earth System Models. Along with ICON, the other model participating in nextGEMS, the IFS-based models form the basis also for Digital Climate Twins of Earth as envisioned in the European Union&amp;#8217;s ambitious Destination Earth project. nextGEMS relies on several model development cycles, in which the models are run and improved based on community feedback. In an initial set of storm-resolving coupled simulations (Cycle 1), the IFS was integrated for 75 days. For Cycle 2, IFS has been run at the operational 9 km resolution as a baseline, and at 4.4 km and 2.8 km global spatial resolution for up to 1 year of simulation (4.4 km). To our knowledge, the 8-months long 2.8 km simulation in Cycle 2 represents the first fully coupled simulation ever of this duration at this high level of spatial detail and is made available to the public. The runs at 9 km were performed with the parameterization for deep convection active as in the operational system, while at 4.4 km and 2.8 km, separate experiments with IFS were run both with and without the deep convection parameterization.We document the model improvements made to IFS-FESOM/NEMO based on the lessons learned from the first Cycle 1 runs, which were included for the second round of Cycle 2 simulations; these mainly consist in vastly improved conservation properties of the coupled model systems in terms of water and energy balance, which are crucial for longer climate integrations, and in a more realistic representation of the snow and surface drag. Cycle 2 also targeted eddy-resolving resolution in large parts of the mid- and high-latitude ocean (better than 5km) to resolve mesoscale eddies and linear kinematic features (i.e. leads or cracks) in sea ice. For IFS-FESOM, this is made possible thanks to a recently refactored ocean model code that can be linked as an external library and that allows for efficient coupled simulations in the single-executable context with IFS, via hybrid parallelization with MPI and OpenMP.
Multicast Wifi Problem Statement (2017)

There have been known issues with multicast, in an 802.11 environment,
which have prevented the deployment of multicast in these wifi
environments. IETF multicast experts have been meeting together to
discuss these issues and provide IEEE updates. The mboned working
group is chartered to receive regular reports on the current state of
the deployment of multicast technology, create practice and
experience documents that capture the experience of those who have
deployed and are deploying various multicast technologies, and provide
feedback to other relevant working groups. As such, this document will
gather the problems of wifi multicast into one problem statement
document so as to offer the community guidance on current limitations.