gebhart/patrepeval huggingface dataset:
Gene Profiling of Canine B-Cell Lymphoma Reveals Germinal Center and Postgerminal Center Subtypes with Different Survival Times, Modeling Human DLBCL (2013)

Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma subtype, and fewer than half of patients are cured with standard first-line therapy. To improve therapeutic options, better animal models that accurately mimic human DLBCL (hDLBCL) are needed. Canine DLBCL, one of the most common cancers in veterinary oncology, is morphologically similar to hDLBCL and is treated using similar chemotherapeutic protocols. With genomic technologies, it is now possible to molecularly evaluate dogs as a potential large-animal model for hDLBCL. We evaluated canine B-cell lymphomas (cBCL) using immunohistochemistry (IHC) and gene expression profiling. cBCL expression profiles were similar in many ways to hDLBCLs. For instance, a subset had increased expression of NF-κB pathway genes, mirroring human activated B-cell (ABC)-type DLBCL. Furthermore, immunoglobulin heavy chain ongoing mutation status, which is correlated with ABC/germinal center B-cell cell of origin in hDLBCL, separated cBCL into two groups with statistically different progression-free and overall survival times. In contrast with hDLBCL, cBCL rarely expressed BCL6 and MUM1/IRF4 by IHC. Collectively, these studies identify molecular similarities to hDLBCL that introduce pet dogs as a representative model of hDLBCL for future studies, including therapeutic clinical trials.
The reaction of cycloheptatriene with methoxycarbonylnitrene: synthesis of 2,3- and 4,5-homo-1H-azepines (1968)

L. A. Paquette and R. J. Haluska, Chem. Commun. (London), 1968, 1370 DOI: 10.1039/C19680001370
2D and 3D frequency-domain elastic wave modeling in complex media with a parallel iterative solver (2015)

Full-waveform inversion and reverse time migration rely on an efficient forward-modeling approach. Current 3D large-scale frequency-domain implementations of these techniques mostly extract the desired frequency component from the time-domain wavefields through discrete Fourier transform. However, instead of conducting the time-marching steps for each seismic source, in which the time step is limited by the stability condition, performing the wave modeling directly in the frequency domain using an iterative linear solver may reduce the entire computational complexity. For 2D and 3D frequency-domain elastic wave modeling, a parallel iterative solver based on a conjugate gradient acceleration of the symmetric Kaczmarz row-projection method, named the conjugate-gradient-accelerated component-averaged row projections (CARP-CG) method, shows interesting convergence properties. The parallelization is realized through row-block division and component averaging operations. Convergence is achieved systematically even when different physical factors such as the space-dependent Poisson’s ratio, free-surface condition, and seismic attenuation are incorporated in the wave modeling. We determined that the scalability of CARP-CG was satisfactory, especially for large-scale applications, using up to several hundred computational cores. We found a potential improvement in computational complexity compared to time-domain modeling through numerical experiments. Finally, we achieved a convergence at 5 Hz in a 3D heterogeneous model, involving fast-slow-fast layers resembling waveguide geometries, with up to several hundred million unknowns, in fewer than 10 h on fewer than 200 cores. All of these results make CARP-CG a potential candidate of the forward modeling engine for seismic imaging on challenging models.
In Vitro Validation of an Artefact Suppression Algorithm in X-Ray Phase-Contrast Computed Tomography (2015)

X-ray phase-contrast tomography can significantly increase the contrast-resolution of conventional attenuation-contrast imaging, especially for soft-tissue structures that have very similar attenuation. Just as in attenuation-based tomography, phase contrast tomography requires a linear dependence of aggregate beam direction on the incremental direction alteration caused by individual voxels along the path of the X-ray beam. Dense objects such as calcifications in biological specimens violate this condition. There are extensive beam deflection artefacts in the vicinity of such structures because they result in large distortion of wave front due to the large difference of refractive index; for such large changes in beam direction, the transmittance of the silicon analyzer crystal saturates and is no longer linearly dependent on the angle of refraction. This paper describes a method by which these effects can be overcome and excellent soft-tissue contrast of phase tomography can be preserved in the vicinity of such artefact-producing structures.
Neonatal Hyperglycaemia Increases Mortality and Morbidity in Preterm Lambs (2012)

Neonatal hyperglycaemia in preterm lambs causes increased mortality and morbidity, and decreases growth. Insulin treatment to restore euglycaemia attenuated the increased mortality and morbidity, but not the decreased growth.
Real-time vehicle performance monitoring using wireless networking. (2004)

A cornerstone of next generation intelligent transportation systems (ITS) is a seamless integration of in-vehicle networking with existing wireless telephony infrastructure. Remote access to on-board diagnostics and performance data is a crucial requirement for ITS. In this paper, we present an extensible vehicle performance monitoring system that exploits data transmission capabilities of GSM, and is based on existing in-vehicle automotive standards. Though many systems currently integrate position tracking and wireless networking to allow for remote position tracking, few systems provide the capability to monitor vehicle performance over the web. Our design is based on a popular new standard for wireless communications — GSM/GPRS. An in-vehicle standard for diagnostic information, ODB-II, is used to gather performance data. We also exploit GPS technology to provide vehicle location. Data is integrated and transmitted to a web server using Apache’s Tomcat extensions to provide Internet access via a vehicle tracking web site. The overall system has been in use for several months on a trial basis at Mississippi State, and will soon be tracking the entire campus bus system. The data collected from this pilot study will form the basis for a research initiative in prediction and optimization of vehicle performance.
Key results of modal testing of the Millennium Bridge, London (2002)

Summary This paper contains key results of modal testing of the Millennium Bridge over the river Thames in London, which suffered excessive lateral vibration on it’s opening day. To control the vibration, Arup designed an installation of fluid -viscous dampers and tuned mass dampers. The testing was performed as part of the programme to verify the likely effectiveness of the proposed modifications. For this purpose two viscous dampers and one bi-axial tuned mass damper were installed on the centre span. The testing of lateral modes of vibration was performed using a custom -built horizontal shaker featuring a moving mass of 1,000 kg. The vertical modes were excited by a small rotating eccentric mass shaker. In both cases excitation forces were measured and used in a frequency response function (FRF) estimation process. The measured FRFs were then curve fitted using linear multi degree of freedom (MDOF) models and this process yielded key modal properties of the targeted modes of vibration: natural frequencies, modal damping ratios, modal masses and mode shapes. It was demonstrated that the prototype viscous and/or tuned mass dampers increased the damping as predicted by Arup’s pre-test analysis. However, examination of the measured FRFs indicated evidence of amplitude-dependent non-linear behaviour of the structure. This required a special interpretation of the FRFs in order to obtain good estimates of the modal masses.
Low voltage sub-nanosecond pulsed current driver IC for high-resolution LIDAR applications (2018)

This paper introduces a new low voltage sub-nanosecond monolithic pulsed current driver for light detection and ranging (LIDAR) applications. Unique architecture based on a controlled current source and Vernier activation sequence, combined with a monolithic implementation that allows operation with low input voltage levels, high-resolution pulse width and sub-nanosecond rise and fall times. An on-chip low voltage pulsed driver sub-nanosecond prototype has been implemented in a TS 0.18-μm 5V-gated power management process. It incorporates an integrated wide range sesnseFET based current sensor and a rail-to-rail comparator for current regulation. To characterize the avalanche capabilities of the integrated lateral MOSFET power devices required for the driver IC, a separate line of investigation has been carried out. Several lateral diffused MOS (LDMOS) power devices have been custom designed and experimentally evaluated for a life-cycle performance characterization. Post-layout analysis of the power driver IC is in a good agreement with the theoretical predictions. For a 5V input voltage, rise and fall times of the laser pulse light output are on the order of hundreds of picoseconds, with currents up to 5A. To validate the concept of high-resolution pulse width generation and short fall time, a discrete prototype has been constructed and experimentally tested.
Exploring a Fine-Grained Multiscale Method for Cross-Modal Remote Sensing Image Retrieval (2021)

Remote sensing (RS) cross-modal text&#x2013;image retrieval has attracted extensive attention for its advantages of flexible input and efficient query. However, traditional methods ignore the characteristics of multiscale and redundant targets in RS image, leading to the degradation of retrieval accuracy. To cope with the problem of multiscale scarcity and target redundancy in RS multimodal retrieval task, we come up with a novel asymmetric multimodal feature matching network (AMFMN). Our model adapts to multiscale feature inputs, favors multisource retrieval methods, and can dynamically filter redundant features. AMFMN employs the multiscale visual self-attention (MVSA) module to extract the salient features of RS image and utilizes visual features to guide the text representation. Furthermore, to alleviate the positive samples ambiguity caused by the strong intraclass similarity in RS image, we propose a triplet loss function with dynamic variable margin based on prior similarity of sample pairs. Finally, unlike the traditional RS image-text dataset with coarse text and higher intraclass similarity, we construct a fine-grained and more challenging Remote sensing Image-Text Match dataset (RSITMD), which supports RS image retrieval through keywords and sentence separately and jointly. Experiments on four RS text&#x2013;image datasets demonstrate that the proposed model can achieve state-of-the-art performance in cross-modal RS text&#x2013;image retrieval task.
Mitral Valve Prolapse: Causes, Clinical Manifestations, and Management (1989)

Prophylaxis for endocarditis and closeness of follow-up should be related to the occurrence of the independent risk factors for complications of mitral prolapse (presence of mitral regurgitation, male gender, and age over 45 years), whereas active management and close observation are needed for severe mitral regurgitation and advanced ventricular arrhythmias.
Exchange Current Density of Solid Oxide Electrolysis Cell Electrodes (2021)

Solid oxide fuel cells (SOFCs) are expected to become widespread as an energy conversion technology that can directly produce electrical energy from fuel. Solid oxide electrolysis cells (SOECs) are essentially SOFCs operating in reverse to produce fuel from electricity. The exchange current density is one of the most important parameters to simulate SOEC/SOFC. In this study, experimental data was evaluated as apparent exchange current density and the effects of SOEC/SOFC operation and different electrode materials were discussed.
Proteinaceous microspheres for targeted RNA delivery prepared by an ultrasonic emulsification method (2012)

In the present work we used sonochemically prepared proteinaceous BSA spheres as a novel RNA-delivery system. The preparation of RNA-loaded BSA spheres was accomplished using an environmental friendly method termed the "ultrasonic emulsification method". It was demonstrated that ultrasonic waves do not cause the RNA chains to degrade and the RNA molecules remain untouched. The BSA-RNA complex was successfully introduced into mammalian (human) U2OS osteosarcoma cells and Trypanosoma brucei parasites. Using PVA coating of the RNA-BSA spheres we have achieved a significant increase in the number of microspheres penetrating mammalian cells. The mechanism of RNA encapsulation and the structure of the RNA-BSA complex are reported.
Marker tracking and HMD calibration for a video-based augmented reality conferencing system (2003)

We describe an augmented reality conferencing system which uses the overlay of virtual images on the real world. Remote collaborators are represented on virtual monitors which can be freely positioned about a user in space. Users can collaboratively view and interact with virtual objects using a shared virtual whiteboard. This is possible through precise virtual image registration using fast and accurate computer vision techniques and head mounted display (HMD) calibration. We propose a method for tracking fiducial markers and a calibration method for optical see-through HMD based on the marker tracking.
Development of High-efficiency 42V Cooling Fan Motor for Hybrid Electric Vehicle Applications (2006)

This paper has objective to develop a 42 V cooling fan system adopting a 42 V BLDC fan motor with metal powdered core for hybrid electric vehicle. So, the influence on a motor design by metal powder is described and the powder is applied as a direct replacement of lamination core. The motor also has been redesigned to take an advantage of the powdered core for improving their performance on the same volume. For the design, the dynamic analysis considering the local magnetic saturation of the stator and the driving pattern by PWM driving circuit is performed based on the coupled finite element analysis with rotor dynamic equations. Also, developed motor and drive circuit is applied to the cooling fan system and compared with simulation results. From the analysis results, it must be noted that the developed type has great advantage over the conventional type toward trend of higher torque per a volume and higher efficiency
User Interface Goals, AI Opportunities (2009)

This is an opinion piece about the relationship between the fields of human‐computer interaction (HCI) and artificial intelligence (AI). The ultimate goal of both fields is to make user interfaces more effective and easier for people to use. But historically, researchers have disagreed about whether “intelligence” or “direct manipulation” is the better route to achieving this. There is an unjustified perception in HCI that AI is unreliable. There is an unjustified perception in AI that interfaces are merely cosmetic. This disagreement is counterproductive. This article argues that AI's goals of intelligent interfaces would benefit enormously by the user‐centered design and testing principles of HCI. It argues that HCI's stated goals of meeting the needs of users and interacting in natural ways would be best served by application of AI. Peace.
A novel approach for separating bacteriophages from other bacteriophages using affinity chromatography and phage display (2013)

Practical applications of bacteriophages in medicine and biotechnology induce a great need for technologies of phage purification. None of the popular methods offer solutions for separation of a phage from another similar phage. We used affinity chromatography combined with competitive phage display (i) to purify T4 bacteriophage from bacterial debris and (ii) to separate T4 from other contaminating bacteriophages. In 'competitive phage display' bacterial cells produced both wild types of the proteins (expression from the phage genome) and the protein fusions with affinity tags (expression from the expression vectors). Fusion proteins were competitively incorporated into the phage capsid. It allowed effective separation of T4 from a contaminating phage on standard affinity resins.
Protocols for Requirement-Driven Protein Design in the Rosetta Modeling Program (2018)

We have developed a set of protocols in the molecular modeling program Rosetta for performing requirement-driven protein design. First, the user specifies a set of structural features that need to be present in the designed protein. These requirements can be general (e.g., "create a protein with five helices"), or they can be very specific and require the correct placement of a set of amino acids to bind a ligand. Next, a large set of protein models are generated that satisfy the design requirements. The models are built using a method that we recently introduced into Rosetta, called SEWING, that rapidly assembles novel protein backbones by combining pieces of naturally occurring proteins. In the last step of the process, rotamer-based sequence optimization and backbone refinement are performed with Rosetta, and a variety of quality metrics are used to pick sequences for experimental characterization. Here we describe the input files and user options needed to run SEWING and perform requirement-driven design and provide detailed instructions for two specific applications of the process: the design of new structural elements at a protein-protein interface and the design of ligand binding sites.
Outcomes From Intraoperative Handovers of Anesthesia Care—Reply (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prognostic value of liver stiffness in patients with tricuspid regurgitation (2022)

Abstract Background It has been known that liver stiffness (LS) assessed by transient elastography is associated with right heart dysfunction and the severity of the tricuspid regurgitation. However, the predictive value of LS for adverse outcome in patients with tricuspid regurgitation (TR) is uncertain. Objectives The aim of this study was to identify the prognostic value of LS in patients with moderate or greater degree of TR. Methods A total of 257 patients with moderate or severe TR who underwent both echocardiography and liver transient elastography were retrospectively analysed. Patients who have congenital heart disease or chronic liver disease including, viral hepatitis, alcoholic liver disease, autoimmune hepatitis, hepatocellular carcinoma were excluded. Severe LS was defined as elevated kilopascal (kPa) ≥11 (High kPa). Primary outcome was defined as the composite of all-cause death and unplanned admission for heart failure. Results One hundred forty-one patients had moderate TR and 116 patients had severe TR. One hundred twenty-eight (50%) patients had severe liver stiffness. During a follow-up period (median 637 days, IQR 1317), 116 (45.1%) primary outcomes occurred. In Kaplan-Meier analysis, patients who had severe TR with high kPa showed the worst outcome. Moreover, patients who had high kPa were associated with worse clinical outcome both moderate TR group and severe TR group than patients with low kPa. In multivariate Cox regression analysis, severe liver stiffness was independently associated with primary outcomes (HR=1.66, 95% CI: 1.28–2.16), p&amp;lt;0.001). Conclusions LS is independently associated with adverse clinical outcomes in both patients with moderate and severe TR. The degree of liver fibrosis measured by transient elastography may be a useful marker of cardiac hepatopathy related to TR, and this may contribute to predict the prognosis of TR. Funding Acknowledgement Type of funding sources: None.
The new integrated flat-steel production facility of HADEED (Saudi Arabia) (2000)

A consortium led by VAI erected for HADEED (Al-Jubail, Saudi Arabia) a new production facility for a wide range of flat rolled products, on a turnkey basis. This giant plant includes a steelshop, a continuous caster, a hot rolling mill, cold rolling facilities, as well as all necessary side installations. The project is characterized by a series of highly new technological solutions and a high degree of automation of the production process (process and quality control).
Comparing Neutron and Ion Irradiation by Atom Probe Tomography and In-situ Electron Microscopy [Slides] (2021)

Stainless steel TPBAR components undergo neutron radiation-induced segregation and dislocation loop formation. Comparison experiments with ion beams accelerate the damage, and visualize the damage process with in-situ microscopy. In-situ Au irradiation causes defect formation, but no elemental segregation.
ASIC Front-End for Multianode Photomultiplier based PET systems with Gain Adjustment and Depth of Interaction measurement (2006)

We present an improved front-end ASIC architecture which can be used either with Multianode Photomultiplier Tubes or with silicon photomultipliers in a continuous crystal Positron Emission Tomography detector. Gamma-ray impact position and depth of interaction is obtained through a DPC charge division network. A Current Sensitive Preamplifier Stage isolates the PM outputs from the resistor network and introduce a digitally programmable gain adjustment. DOI is calculated from the width of the scintillation light distribution which can be obtained from the sum of anode voltages. A stage of transconductance amplifiers and a high speed current mode adder scheme do the voltage addition operation.
Linking of metal centres through boryl ligands: synthesis, spectroscopic and structural characterisation of symmetrically bridged boryl complexes (2002)

Dinuclear species containing iron centres linked via various bridging boryl ligands have been synthesised and a combination of crystallographic, computational and spectroscopic (Mössbauer, IR, Raman) techniques have been used to probe the bonding in these complexes.