gebhart/patrepeval huggingface dataset:
Enumeration of polyclonal mitogen-responsive cells in different lymphoid tissues of the mouse. (1976)

The relative number of cells capable of responding to Con A, PHA and LPS in the spleen, blood, lymph node and Peyer's patches of CBA mice has been quantified by means of a cytological analysis technique. No difference has been found between Con A- and PHA-responsive cells in spleen and lymph node. The lymphoid tissues of T cell-deprived mice have a reduced content of PHA responsive cells, but LPS responsiveness is within normal limits. Pretreatment of peripheral lymphocyte populations with high concentrations of anti-O antiserum and complement abolishes the response of the treated cells to PHA, but not to LPS, whereas similar treatment with a cytotoxic anti-immunoglobulin serum, which has no effect on PHA-responsive cells, only partially reduces the response to LPS. The results for mitogen responsiveness are discussed with reference to other methods of quantifying T and B cells using cell-surface markers.
Mutant of Escherichia coli that instantaneously loses the ability to adsorb lambda bacteriophage upon exposure to high temperature (1976)

lad (lambda adsorption), an Escherichia coli mutant that loses the ability to adsorb lambda phage immediately after a shift to high temperature (e.g., 42 C), was isolated. This property for phage adsorption is irreversible and has been observed with phage lambda and 21 but not with phages 434, phi 170, and phi 80. A crude receptor preparation, extracted from lad cells will cholate-ethylenediaminetetraacetic acid by the procedure of Randall-Hazelbauer and Schwartz (1973), inactivated the phage lambda only at low temperature.
Generation of sub-nanosecond shaped 5 - 50mJ pulses from a compact regenerative Yb<sup>3+</sup>: YAG MOPA (2006)

We demonstrate the capability of a highly efficient Yb <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3+</sup> :YAG regenerative MOPA system to produce sub-nanosecond shaped pulses at 10 to 50 mJ energy. The main design issues are reviewed versus the pulse width-energy trade off
Parallel processing in machine vision (1984)

SUMMARY Machine vision systems incorporating highly parallel processor architectures are reviewed. A new processor architecture, the image flow computer, is presented in detail. An interactive image processing programming language based on mathematical morphology is then presented. A detailed example of the use of the system for the inspection of a particular industrial part concludes the presentation.
Oral Food Challenges (Procedure) (2015)

This chapter discusses the indications, procedure, diagnosis, management of complications, and follow-up for oral food challenges. The patient's clinical history, skin prick tests, and serum food-specific IgE antibody levels are useful for making the diagnosis of food allergy. However, without an unequivocal allergic reaction to isolated food ingestion with supportive laboratory data, some form of oral food challenge is necessary to establish the diagnosis of a food allergy. The double-blind placebo-controlled oral food challenge is the “gold standard” for diagnosing food allergy. When the food challenge is negative, or when ingestion of a food induces the same symptoms as reported in the history, the single-blind or open challenge is sufficiently specific to confirm the diagnosis of food allergy. Oral food challenges are typically used to confirm the presence of food allergy or demonstrate that a patient, typically a child, has outgrown their food allergy.
The Localization of Digital Games: A Case Study in China (2005)

This paper examines the challenges that game localization is confronting. By focusing on China, the paper explores the uniquenesses of digital games and proposes a three-dimension model for evaluating and improving game localization. These three dimensions include In-Game Environment, External Environment, and Users. The paper analyzes both successful and failed foreign games in China in connection with the three-dimension approach. It argues that these three dimensions are highly influential and they should be considered throughout the whole game design process.
Surgical rehabilitation of the planovalgus foot in cerebral palsy (2001)

The objectives of this study were to quantitatively determine the effects of subtalar arthrodesis on the planovalgus foot using three-dimensional (3-D) gait analysis and plantar pressure measurements. Twelve children and adolescents with planovalgus foot deformity secondary to spastic cerebral palsy participated in this outcome study. The pediatric population were evaluated preoperatively and following subtalar fusion. Seventeen feet were operated for the correction of the planovalgus foot deformity. A Holter-type microprocessor-based portable in-shoe data acquisition system was used in this study to collect the multistep dynamic plantar pressure history, while a five-camera Vicon-based gait analysis system was used to track the lower extremity joint kinematics. The results obtained from the plantar pressure measurement showed significant increases in mean peak vertical plantar pressures postoperatively at the lateral midfoot and lateral metatarsal heads. Mean contact durations and mean pressure-time integrals were also significantly increased at these plantar locations following foot surgery. This redistribution in pressure metrics suggests the formation of new lateral plantar weight bearing areas. The 3-D gait analysis system, using standardized lower extremity measurements, was unable to reveal any significant changes in joint kinematics, particularly at the foot and ankle where the surgery was performed. This suggests the need for a more refined system to track the complex motion of the pediatric foot and ankle during gait.
wo guo yi liao qi xie sheng chan qi ye cun zai de wen ti ji dui ce fen xi (2016)

目前国内医疗器械生产企业众多,产品质量水平参差不齐,由医疗器械产品质量引起的问题也越来越多。2002年1月1日至2014年12月31日,国家药品不良反应监测中心累计收到《可疑医疗器械不良事件》1000,805份,数量也呈逐年增长趋势。
NF-κB1 Is Required for Optimal CD4+ Th1 Cell Development and Resistance to Leishmania major (2003)

The NF-kappaB family of transcription factors regulates the expression of a wide range of immune response genes involved in immunity to pathogens. However, the need for individual family members in regulating innate and adaptive immune responses in vivo has yet to be clearly defined. We investigated the role of NF-kappaB1 in the induction of protective IL-12-dependent Th1 cell responses following infection with the intracellular protozoan parasite Leishmania major. Whereas wild-type C57BL/6 mice controlled parasite replication, NF-kappaB1 knockout (KO) mice were susceptible to infection, developing chronic unresolving lesions associated with persistent parasites. There was a profound defect in Ag-specific CD4(+) T cell proliferation and IFN-gamma production in infected KO mice, although innate responses-including IL-12 production and control of intracellular parasite replication by macrophages-were intact. In vitro polyclonal stimulation of purified naive KO T cells revealed an intrinsic defect in CD4(+) T cell proliferation associated with reduced IL-2 receptor expression, but operating independently of APC function and IL-2 production. Critically, the frequency of proliferating KO CD4(+) T cells secreting IFN-gamma matched that of wild-type cells, suggesting that NF-kappaB1 was not required for efficient transcription of the IFN-gamma gene. Taken together, these results identify a novel role for NF-kappaB1 in CD4(+) T cell proliferation and the development of Th1 cell responses required for protective immunity against intracellular pathogens.
Detecting Driver-induced Steering Oscillations through Adaptive Thresholding of the Power Spectrum of Vehicle's Lateral Acceleration (2018)

This study propose an approach for detecting the steering oscillations caused by delayed steering response in a human driver in normal driving (routine) scenarios. The delayed steering response is a result of inadequate cognitive load on distracted or cognitively overloaded drivers. The proposed approach is based on real-time thresholding of the power spectrum magnitude of a Fourier-transformed signal, which is obtained from the lateral acceleration of a car. However, even if the power spectrum magnitude of inattentive driving is higher than that of fully attentive driving in the same driving scenario because of steering oscillations, it varies significantly when the driving scenario changes. Inattentive driving along straightaways yields anomalously lower power spectrum values than those obtained from attentive driving when cornering. Therefore, it would be unfeasible to employ a single threshold to detect steering oscillations across all driving situations. Hence, we propose using the absolute value of the lateral jerking motion of a car as an indication that the car is entering or exiting a corner. The experimental results indicated that adaptive thresholding of the power spectrum of lateral acceleration facilitates the detection of driver-induced steering oscillation with an overall accuracy of 88%.
ChemInform Abstract: Potential Antimalarials. Part 19. Syntheses and Testing of α‐( Piperidin‐2‐yl)‐α‐(7′‐trifluoromethylquinolin‐4′‐yl)methanol (VI) and α‐(7‐Bromo‐1,5‐naphthyridin‐4‐yl)‐α‐(piperidin‐2′‐yl) methanol (VII). (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Immune Mechanisms in Bacillus Calmette-Guerin Immunotherapy for Superficial Bladder Cancer (2003)

The efficacy of BCG is based on a complex and long lasting local immune activation. The bladder as a confined compartment, in which high local concentrations of the immunotherapy agent and effective recruitment of immune cells can be achieved, serves as an ideal target organ for this type of immunotherapy approach.
Hirshfeld surface analysis (2008)

In the last few years the analysis of molecular crystal structures using tools based on Hirshfeld surfaces has rapidly gained in popularity. This approach represents an attempt to venture beyond the current paradigm—internuclear distances and angles, crystal packing diagrams with molecules represented via various models, and the identification of close contacts deemed to be important—and to view molecules as “organic wholes”, thereby fundamentally altering the discussion of intermolecular interactions through an unbiased identification of all close contacts.
The Replacement Cost Integration Program: User's guide (1989)

The Oak Ridge National Laboratory and subcontractor ICF-Lewin Energy have developed a set of computer models to forecast the replacement cost of domestic crude oil. The REPCO model forecasts the replacement cost in the lower 48 states. The Arctic Economics Model forecasts the replacement cost in Alaska. The two models of the replacement cost system forecast domestic crude oil supply curves (schedules of the amount of oil available at various costs). The Replacement Cost Integration Program (RCIP) integrates the output from the two models to forecast the annual discoveries and production of domestic crude oil. RCIP is a user-friendly menu-driven program that is designed to run on an IBM-PC. This user's guide for RCIP contains detailed directions for installing and operating RCIP. The guide discusses all of the parameters on the input screens of the model. The format and units of the output files of the model are reviewed in Appendix B.
Multimode-ultrasound and microwave assisted natural ternary deep eutectic solvent sequential pretreatments for corn straw biomass deconstruction under mild conditions (2020)

Mild and effective pretreatments are essential to deconstruct lignocellulosic biomass so as to reuse cellulose content for value-added products. In this study, sequential multimode-ultrasound and microwave with natural ternary deep eutectic solvent (NATDES) pretreatments were used to deconstruct corn straw and optimized factors such as NATDES, ultrasonic, and microwave parameters. Results indicated that the ultrasound-NATDES or microwave-NATDES pretreatment could remove 37.86% and 52.36% lignin, respectively. When using sequential multimode-ultrasound and microwave assisted NATDES pretreatment, the delignification efficiency increased to 61.50%, and the cellulose content increased from 34.70% to 76.08%. In addition, the delignification of sequential multimode-ultrasound and microwave assisted NATDES pretreatment (under the mild conditions of microwave heating at 60 °C and 60 min) increased to 57.39%, and the cellulose content increased to 59.98%, too. This highlighted the effect of the combined ultrasound and microwave technology. Finally, the microstructural changes of mercury intrusion porosimeters, scanning electron microscopy, thermogravimetric, X-ray diffraction and Fourier transform mid-infrared spectroscopy were conducted to confirm the effectiveness of this method to deconstruct corn straw. A mechanism of the deconstruction of corn straw biomass in NATDES with the assistance of the sequential multimode-ultrasound and microwave heating was proposed. This research could open a window for future use of biomass energy by deconstructing lignocellulosic biomasses using environmentally friendly pretreatment methods.
New concept in coronary angioplasty: Dilatation with a helical balloon that allows simultaneous autoperfusion (1997)

These preclinical studies investigate a new concept in coronary angioplasty and balloon catheter technology (the P100 catheter). The study sought to evaluate the morphology of experimental coronary arterial plaques dilated with the P100 in comparison to standard balloons, to determine the in vitro flow rates occurring during the inflation of the P100 in comparison to available perfusion catheters, and to assess the in vivo coronary flow velocity and the presence of ischemia during prolonged inflations with the P100. The development of myocardial ischemia is a major limitation of standard balloon angioplasty. To limit ischemia, autoperfusion catheters have been developed, in which blood flows through the balloon in the central catheter shaft. However, as the flow lumen profile is reduced to enhance the performance of these devices, so is the accompanying flow. An angioplasty catheter was designed to evaluate the feasibility of continuous autoperfusion around the dilatation balloon. The balloon surface was engineered to develop a helical trough for blood flow to occur during inflation. Arterial plaque morphology following angioplasty with the P100 (n = 8) and with standard balloons (n = 8) was evaluated in a swine model. In vitro flow rates during inflation of the P100 and available perfusion catheters were determined using 33% glycerol solution. In vivo coronary flow velocity was determined with a Doppler-tipped wire during 60-min continuous inflations with the P100, and 15-sec inflations with a standard balloon in 12 vessel segments in 7 dogs; using 3.0–3.5-mm-diameter balloons. All lesions were successfully dilated (<50% luminal diameter stenosis) with the P100 and standard balloons. There were no morphologic differences in plaques dilated with P100 compared to standard balloons. In vitro flow rates with conventional 3.0-mm balloon perfusion catheters ranged from 27.1 ± 2.1 ml/min (RX Flowtrack™) to 38.7 ± 0.9 ml/min (Stack Perfusion™), P < .05. Flow with the P100 ranged from 54.8 ± 4.3 ml/min (2.5-mm balloon) to 103.2 ± 4.5 ml/min (3.5-mm balloon), P <.05. Distal average peak coronary flow velocity during prolonged P100 inflations varied from 69 ± 7% of baseline at 5 min to 83 ± 8% of baseline at 40 min, with an upward trend in velocity the longer the balloon was inflated. Hemodynamics remained stable. Experimental plaques are successfully dilated with a helical balloon by a mechanism that appears similar to the dilatation mechanism of standard balloons. These preclinical studies show that angioplasty and autoperfusion can be accomplished by a balloon that does not have complete surface area contact with the vessel wall. A gap created by the helix can thus provide a conduit for blood flow. Clinical studies will determine whether this innovation, which alters the tubular geometry of current angioplasty balloons, will provide autoperfusion and equivalent dilatation effects in humans. Cathet Cardiovasc Diagn 40:109–116, 1997. © 1997 Wiley-Liss, Inc.
The selectivity filter of a ligand‐gated ion channel (1989)

Evidence from electrophysiology and biochemistry supports the hypothesis that the ion channel of the nicotinic acetylcholine receptor is formed by homologous amino acid sequences of all receptor subunits, called helices M2. A model of the ion channel is proposed and the selectivity filter is described as a ring of negatively-charged amino acid side chains [(1988) Nature 335, 645-648] which may undergo conformational changes upon permeation of the cation.
Determining activity using a triaxial accelerometer (2002)

Triaxial accelerometers have been employed to monitor human movements in a variety of circumstances. It is necessary, however, to be able to extract useful information from the acceleration measurements. We show that we can, in a controlled environment, use an energy expenditure method to identify and separate dynamic activities, including changes in posture and ambulation.
Nitrogen-nitrogen double bond cleavage and the ortho metalation of azoarenes using Ru3(NPh)(CO)10 (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNitrogen-nitrogen double bond cleavage and the ortho metalation of azoarenes using Ru3(NPh)(CO)10Joanne A. Smieja, John E. Gozum, and Wayne L. GladfelterCite this: Organometallics 1987, 6, 6, 1311–1317Publication Date (Print):June 1, 1987Publication History Published online1 May 2002Published inissue 1 June 1987https://pubs.acs.org/doi/10.1021/om00149a029https://doi.org/10.1021/om00149a029research-articleACS PublicationsRequest reuse permissionsArticle Views158Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Review Of Rotavirus Vaccine Trials In Finland (1996)

Oral rotavirus vaccines, including bovine rotavirus strains RIT 4237 and RIT 4256, rhesus rotavirus (RRV) vaccine, rhesus-human rotavirus vaccine reassortants (D x RRV, DS-1 x RRV, and tetravalent RRV), and human nursery rotavirus strain M37, have been evaluated in 5353 Finnish infants for safety, immunogenicity, and efficacy against rotavirus gastroenteritis. Bovine rotavirus vaccines were nonreactogenic in infants, whereas RRV-based and M37 vaccines were occasionally associated with febrile reactions 2-5 days after vaccination. All vaccines showed dose-dependent immunogenicity. Vaccine efficacy correlated with overall immunogenicity but not with the vaccine virus G serotype. For each vaccine, protective efficacy was better against severe rotavirus disease than against any rotavirus-associated gastroenteritis. Maximal protective efficacy against any rotavirus gastroenteritis in subjects with demonstrable vaccine immunogenicity was approximately 75%. To achieve similar protection in all vaccinees, efforts should be focused on enhancing the immunogenicity of oral rotavirus vaccines.
Designing Ionic Liquid-Derived Polymer Composites from Poly(Ionic Liquid)–Ionene Semi-interpenetrating Networks (2021)

While the solvating power of ionic liquids (ILs) for a variety of solute types including polymers is well-known, the use of ILs as solvents for ionenes—charged polymers with cationic moieties within the backbone—has only recently begun to be explored. IL–ionene combinations offer vast possibilities to make iongels and perhaps even use ILs to exert control over ionene organization (i.e., coil or rod). If the IL solvent is also polymerizable, then poly(IL)–ionene semi-interpenetrating networks (semi-IPNs) can be achieved. This study reports, for the first time, examples of poly(IL)–ionene semi-IPNs formed by dissolving an ionene in a vinyl-functionalized imidazolium IL followed by subsequent photopolymerization of the IL around the ionene. The resultant poly(IL)–ionene semi-IPNs exhibit greater elasticity and ionic conductivity than the neat poly(IL). Thus, the addition of 10–20 wt % ionene can lead to significant changes in the properties of poly(IL) materials. Given the limitless possibilities for IL and ionene structures, this unique type of ionic composite presents vast opportunities for material design.
Quantitative myocardial inflammation assessed using a novel USPIO-Magnetic Resonance Imaging acquisition and analysis protocol (2013)

Background Ultrasmall superparamagnetic particles of iron-oxide (SUPIO) particles can be used as a magnetic resonance imaging contrast (MRI) agent. Due to their dextran coating and small diameter (<30 nm), they are phagocytised by inflammatory cells [1]. The aim of this study was to assess whether a novel acquisition/registration USPIO-MRI protocol could be used to assess myocardial cellular inflammation. Myocardial infarction and cardiac surgery was used to model myocardial inflammation [2]. An influx of macrophages can be seen in post-mortem histology, however the dynamics of in vivo patho-physiology is uncertain [3].
Mathematical Framework for Hydromechanical Time-Domain Simulation of Wave Energy Converters (2018)

Efficient design of wave energy converters based on floating body motion heavily depends on the capacity of the designer to accurately predict the device’s dynamics, which ultimately leads to the power extraction. We present a (quasi-nonlinear) time-domain hydromechanical dynamic model to simulate a particular type of pitch-resonant WEC which uses gyroscopes for power extraction. The dynamic model consists of a time-domain three-dimensional Rankine panel method coupled, during time integration, with a MATLAB algorithm that solves for the equations of the gyroscope and Power Take-Off (PTO). The former acts as a force block, calculating the forces due to the waves on the hull, which is then sent to the latter through TCP/IP, which couples the external dynamics and performs the time integration using a 4th-order Runge-Kutta method. The panel method, accounting for the gyroscope and PTO dynamics, is then used for the calculation of the optimal flywheel spin, PTO damping, and average power extracted, completing the basic design cycle of the WEC. The proposed numerical method framework is capable of considering virtually any type of nonlinear force (e.g., nonlinear wave loads) and it is applied and verified in the paper against the traditional frequency domain linear model. It proved to be a versatile tool to verify performance in resonant conditions.