gebhart/patrepeval huggingface dataset:
Stratospheric Radar Observations of Convection and Precipitation (2019)

International audience
The Interaction of Walsh‐Orbitols in Diademane and Related Hydrocarbons (1973)

Abstract To obtain further information concerning the interaction between Walsh ‐orbitols of ‘conjugated’ cyclopropane rings, the photoelectron spectra of the following compounds have been recorded: bicyclo[4.1.0]heptane 1 , cis ‐ and trans ‐tricyclo[5.1.0 3, 5 ]octane 2, 3 , diademane 4 , trans ‐pentacyclo[3.3.2.0 2, 9 .0 4, 10 , 0 6, 8 ]decan 5 and bicyclo[4.1.0]heptene‐2 6 . The first bands in the PE.‐spectra of these compounds have been assigned on the basis of a ZDO HMO‐approximation. For 2 and 4 the value for resonance integral between linked 2p atomic orbitals of two adjacent eclipsed cyclopropane rings is found to be −1.73 eV.
Systematic in silico analysis of clinically tested drugs for reducing amyloid‐beta plaque accumulation in Alzheimer's disease (2021)

A QSP model can provide novel insights to clinical results. Our model explains the results of clinical trials and provides guidance for future therapeutic development.
AlGaN Schottky diodes for detector applications in the UV wavelength range (2008)

We report on the use of TCAD simulations to optimize AlGaN UV-detectors for space applications and advanced EUV lithography tools. (i) High dark current in present AlGaN Schottky diodes is explained by means of the Thin Surface Barrier model. (ii) This model and AlGaN material properties were implemented in TCAD software and verified with experimental results, facilitating future technology development. (iii) Key issues in technology development were identified and experimentally verified: reducing surface defects is shown to result in order-of-magnitude dark current reduction. (iv) A full semi-transparent Schottky contact is shown to provide a good compromise between low leakage and sufficient photocurrent.
Controle de Cornitermes cumulans (Kollar, 1832) Isoptera: Termitidae) com Beauveria bassiana (Bals.) Vuill; e Metarhizium anisopliae (Metsch) Sorok. em condições de campo (1991)

Control afCornilermes corno/aos )Kollar, 1832) (Isoptera: Termitidae) wtth Beauvcr,a bassiana (Bala.)Vuili.and Mc(cirhiziurn onisop/ioc (M-tsch .) Sorok under field conditions.Under field conditions Corniterrne cunn,Ians nesta were Lreated with tg. of conidia from 2 isolates o! Renovaria bassiuna and Me-- torhiziurn anisop
Tunable single-photon heat conduction in electrical circuits (2012)

We build on the study of single-photon heat conduction in electronic circuits taking into account the back-action of the superconductor--insulator--normal-metal thermometers. In addition, we show that placing capacitors, resistors, and superconducting quantum interference devices (SQUIDs) into a microwave cavity can severely distort the spatial current profile which, in general, should be accounted for in circuit design. The introduction of SQUIDs also allows for in situ tuning of the photonic power transfer which could be utilized in experiments on superconducting quantum bits.
Lung Epithelial Cell Prep (2015)

This protocol is broadly applicable for obtaining primary lung epithelial cells from adult mice.
LA ALIMENTACIÓN DE LOS ADOLESCENTES: UN ABORDAJE COMPLEMENTARIO ENTRE LA BIOLOGÍA Y LA CULTURA (2013)

&lt;p&gt;El artículo consolida la base teórica de la investigación que se sustenta a partir del principio de “el ser humano es un sistema complementario que involucra tanto procesos biológicos y culturales”. El abordaje del estudio de las prácticas alimenticias y alimentarias de los adolescentes se hace bajo dos perspectivas necesarias para brindar una comprensión más amplia y profunda del fenómeno: la biología y la cultura. Estos enfoques se caracterizan por ser complejos y opuestos entre sí, lo que implica una postura filosófica, epistemológica y metodológica. En coherencia con lo anterior este artículo se sustenta filosóficamente desde el principio de la complementariedad que acepta dos paradigmas opuestos, pero complementarios entre sí, el positivista que sirve como marco para la descripción de los sujetos desde la dimensión biológica y el interpretativo fundamento de la cultura.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Palabras clave:&lt;/strong&gt; Complementariedad, Positivismo, Hermenéutica, Biología, Cultura,&lt;/p&gt;
Multilayer bandstop filter for ultra wideband systems (2009)

A multilayer broadside-coupled microstrip-slot-microstrip structure is used to design a bandstop filter with a wide passband for ultra wideband (UWB) applications. The design procedure for the proposed filter is based on the conformal mapping technique and the even- and odd-mode analysis. The theoretical analysis indicates that value of the coupling factor between the top and bottom layers of the structure can be used to control the width of the stopband, whereas centre of that band can be controlled by the length of the coupled structure. To limit the passband of the proposed bandstop filter to 3.1–10.6 GHz, which is the specified bandwidth for UWB systems, a broadside-coupled bandpass filter is integrated with the proposed device. The simulated and measured results show that the proposed device achieve &lt;0.5 dB insertion loss across most of the passband and &gt;20 dB insertion loss at the stopband. The device also shows a flat group delay across the passband with &lt;0.15 ns peak-to-peak variation. Hence, it is a suitable choice for the UWB systems that require a distortionless operation.
Higher-throughput screening with human cytochromes P450. (1999)

Recent progress has been made in increasing the throughput of measurements of cytochrome P450-mediated metabolism of drug candidates. This review focuses on two innovations: (i) the reduction of the number of samples for HPLC-based analyses by simultaneous measurement multiple analytes in a single injection (N in one analysis) and (ii) screens for the inhibition of cytochrome P450-mediated metabolism (a mechanism for drug-drug interactions) using fluorometric assays. Both of these innovations substantially increase the throughput and decrease the resources needed for conducting these routine preclinical studies.
Two subsites in the binding domain of the acetylcholine receptor: an aromatic subsite and a proline subsite. (1995)

The ligand binding site of the nicotinic acetylcholine receptor (AcChoR) is localized in the alpha-subunit within a domain containing the tandem Cys-192 and -193. By analyzing the binding-site region of AcChoR from animal species that are resistant to alpha-neurotoxins, we have previously shown that four residues in this region, at positions 187, 189, 194, and 197, differ between animals sensitive (e.g., mouse) and resistant (e.g., mongoose and snake) to alpha-bungarotoxin (alpha-BTX). In the present study, we performed site-directed mutagenesis on a fragment of the mongoose AcChoR alpha-subunit (residues 122-205) and exchanged residues 187, 189, 194, and 197, either alone or in combination, with those present in the mouse alpha-subunit sequence. Only the mongoose fragment in which all four residues were mutated to the mouse ones exhibited alpha-BTX binding similar to that of the mouse fragment. The mongoose double mutation in which Leu-194 and His-197 were replaced with proline residues, which are present at these positions in the mouse AcChoR and in all other toxin binders, bound alpha-BTX to approximately 60% of the level of binding exhibited by the mouse fragment. In addition, replacement of either Pro-194 or -197 in the mouse fragment with serine and histidine, respectively, markedly decreased alpha-BTX binding. All other mutations resulted in no or just a small increase in alpha-BTX binding. These results have led us to propose two subsites in the binding domain for alpha-BTX: the proline subsite, which includes Pro-194 and -197 and is critical for alpha-BTX binding, and the aromatic subsite, which includes amino acid residues 187 and 189 and determines the extent of alpha-BTX binding.
Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs (2009)

Activation of naive CD8(+) T cells with antigen induces their differentiation into effector cytolytic T lymphocytes (CTLs). CTLs lyse infected or aberrant target cells by exocytosis of lytic granules containing the pore-forming protein perforin and a family of proteases termed granzymes. We show that effector CTL differentiation occurs in two sequential phases in vitro, characterized by early induction of T-bet and late induction of Eomesodermin (Eomes), T-box transcription factors that regulate the early and late phases of interferon (IFN) gamma expression, respectively. In addition, we demonstrate a critical role for the transcription factor Runx3 in CTL differentiation. Runx3 regulates Eomes expression as well as expression of three cardinal markers of the effector CTL program: IFN-gamma, perforin, and granzyme B. Our data point to the existence of an elaborate transcriptional network in which Runx3 initially induces and then cooperates with T-box transcription factors to regulate gene transcription in differentiating CTLs.
18.4 An 1.1V 68.2GB/s 8Gb Wide-IO2 DRAM with non-contact microbump I/O test scheme (2016)

The emergence of the internet of everything (IoE) demands high-performance, real-time multi-media and wideband networking in battery-operated mobile systems. For this reason, higher bandwidth and lower power mobile DRAMs are becoming increasingly critical. As promising candidates of next-generation mobile DRAM, the development of LPDDR4 [1] and wide-IO2 (WIO2) DRAM is ongoing these days. The conventional single data rate (SDR) wide IO DRAM [2] has achieved ×4 data bandwidth compared to LPDDR2 by increasing the number of IOs (e.g. 512 DQs). The WIO2 DRAM in this paper has 512 DQs, which is the same as SDR wide-IO DRAM, but by using double data rate (DDR) and operating at 1066Mb/s, its bandwidth achieves 68.2GB/s, which is quadrupled compared to LPDDR4 (single-die comparison). Moreover, since WIO2 DRAM is stacked in a 3D structure with the DRAM controller (system-in-package type), the input/output capacitance (CIO) is decreased and a power efficiency of 28mW/GB/s in READ operation mode is achieved.
Two-dimensional interaction of spin chains in the Si(553)-Au nanowire system (2016)

Adsorption of Au on Si(553) results in the self-assembly of highly ordered step arrays of one-dimensional (1D) Au atomic wires along the step direction. Charge transfer from the terrace to the step edge causes every third Si atom at the step edge to exhibit a partially filled dangling bond hosting a single fully spin-polarized electron which forms in an ordered 1D spin chain along the step. The interstep correlation of this threefold periodicity in neighboring Si step edges and the geometry of the unit cell has been determined by means of high-resolution spot profile analysis low-energy electron diffraction, scanning tunneling microscopy, and density functional theory. While the twofold periodicity of the Au wires exhibits a weak interwire interaction, leading to streaks in the diffraction pattern, the correlation of the Si step edge atoms is by far a stronger interaction, resulting in clear spots. The corresponding unit cell spanned by threefold ordered step edge atoms can be described as a centered structure which is magnetically frustrated and may stabilize a (two-dimensional) quantum spin liquid.
Serum levels of immunoreactive bone sialoprotein in osteoporosis: positive relations to established biochemical parameters of bone turnover. (2001)

Bone Sialoprotein (BSP), synthesized by osteoblasts and osteoclasts, is a highly glycosylated and phosphorylated protein, accounting for approximately 5-10% of noncollagenous proteins of bone extracellular matrix. The present study investigates possible correlations between serum values of immunoreactive Bone Sialoprotein in relation to established bone turnover markers like osteocalcin (OC), bone alkaline phosphatase (B-ALP) and the c-terminal extension peptide of type-I-Procollagen (PICP) in 170 osteoporosis patients (female n = 144, male n = 26) in order to evaluate the usefulness of BSP in the diagnosis of bone disease. Fasting venous blood samples were collected from our osteoporosis outpatients in the morning and stored at -80 degrees C until processing. Serum levels of BSP were determined by RIA, OC and B-ALP were measured by IRMA, and PICP was assessed employing an ELISA technique. A significant correlation was found between BSP serum values and B-ALP (r = 0.532, p = 0.0001). Median serum BSP levels were 8.0 micrograms/l, median B-ALP values were 22.39 U/ml in these patients. Also a significant correlation was observed between BSP and OC (r = 0.588, p = 0.0001), more pronounced in the female patient group (r = 0.632, p < 0.0001). A weak association between BSP and PICP in the female group was detected (r = 0.398, p = 0.0001). In the female group BSP was inversely related to serum estradiol levels (r = -0.274, p = 0.002) as to BMD (DEXA) at the lumbar spine and femoral neck. In conclusion, BSP might be a useful marker of non-collagenous organic bone matrix in laboratory assessment of bone turnover, being inversely related to BMD at lumbar spine and femoral neck and showing significant correlations to established markers of bone turnover like B-ALP and OC.
Fundamental study of low-NOx combustion fly ash utilization. Semiannual report, May 1, 1998--October 31, 1998 (1999)

The objective of the current work was to investigate the oxidation reactivity of fly ash carbons, using thermogravimetric analysis techniques. Good measures of the oxidation reactivity of fly ash carbon were the critical temperature (T{sub cr}) and the late burnout temperature (T{sub late}). The lower the critical temperature of the fly ash carbon, the more reactive the sample. By contrast, the higher T{sub late}, the less reactive the fly ash carbon. The difference between T{sub cr} and T{sub late} provided information about the reactivity distribution and was mainly dependent on fly ash carbon content (Loss-On-Ignition (LOI)). Fly ash carbons having different origins, some from lower rank coals and some from higher rank coals had slightly different reactivities. Class C fly ash carbons from low rank coals were more reactive than the typical class F fly ash carbons from higher rank coals. The reactivity parameters did not, however, provide any additional ability to predict the suitability of a given ash for use in concrete.
Frame synchronization for optical overlapping pulse-position modulation systems (1992)

The maximum-likelihood rules for locating data frames in direct-detection optical communication systems utilizing overlapping pulse-position modulation (OPPM) are derived under two distinct assumptions of symbol and chip synchronization, respectively. Various approximations to the optimal rules are identified, as well as upper and lower bounds on the probability of correct synchronization. Further, the problem of sequence design based on a maximum peak-to-sidelobe distance criterion is studied, and upper bounds on peak-to-sidelobe distance for sequences of OPPM symbols are derived. Some good sequences are obtained through a computer search.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Colorimetric Determination of 3,6-Anhydrogalactose and Galactose in Marine Algal Polysaccharides (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTColorimetric Determination of 3,6-Anhydrogalactose and Galactose in Marine Algal PolysaccharidesWilfred. YapheCite this: Anal. Chem. 1960, 32, 10, 1327–1330Publication Date (Print):September 1, 1960Publication History Published online1 May 2002Published inissue 1 September 1960https://pubs.acs.org/doi/10.1021/ac60166a030https://doi.org/10.1021/ac60166a030research-articleACS PublicationsRequest reuse permissionsArticle Views471Altmetric-Citations114LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
07: Softwaretechnik 1, Vorlesung, SS 2017, 19.05.2017 (2017)

07 | 0:00:00 Starten 0:00:10 Objekt-/Instanzdiagramm 0:05:07 Assoziation vs. Verknüpfung 0:08:34 Interpretation der Multiplizität 0:15:44 Assoziationsklassen 0:23:48 Klassenattribute und -methoden 0:30:21 Vererbung 0:39:17 Ist-ein Beziehung 0:42:09 Liskovsches Substitutionsprinzip 0:55:01 Schnittstelle
Exogenous albumin inhibits sorafenib-induced cytotoxicity in human cancer cell lines (2012)

Sorafenib is an orally administered multikinase inhibitor that exhibits anti-angiogenic and anti-tumor activity. Sorafenib is also known to bind to protein (>99.5%), suggesting protein binding may be involved in sorafenib pharmacokinetic variability. Albumin is a major drug-binding protein. In this study, we examined the effect of albumin on sorafenib-induced cytotoxicity using two <i>in vitro</i> culture cell lines, human hepatoma Huh-7 cells and androgen-independent prostate cancer PC-3 cells. The cells were cultured and incubated, and cytotoxicity was assessed. Results were confirmed by western blotting. The presence of exogenous albumin markedly blocked the sorafenib-induced cytotoxicity in the two cell lines. Albumin concentration, the change of pharmacological signal transduction as Raf-B, vascular endothelial growth factor (VEGF), and phosphorylation of MEK1/2 or ERK1/2 were found to be decreased by sorafenib. Co-incubation of warfarin, a representative coumarin anticoagulant and potent binding activity, with albumin enhanced the cytotoxic effects by sorafenib. These mechanisms depend on the high binding proper ties of sorafenib and exogenous albumin. Furthermore, we investigated the effects of endo genous albumin expression on sorafenib-induced cytotoxicity using the siRNA knockdown system or transfected expression vector assay. However, the cytotoxic effects by sorafenib showed little change either with the knockdown or overexpression of albumin. Our results suggest that particular care should be taken with albuminemia or the combined use of drugs with a high affinity for albumin, such as warfarin, and sorafenib in the treatment of cancer patients. Our findings may be useful to the cancer therapeutic strategy by sorafenib.
Immunomodulatory Function of Mesenchymal Stem Cells for Rheumatoid Arthritis (2016)

Developments in our comprehension of the autoimmune and inflammation mechanisms in rheumatoid arthritis (RA) have produced targeted therapies that block aberrant immune cells and cytokine networks, and improved treatment of RA patients considerably. Nevertheless, limitations of these treatments include incomplete treatment response, adverse effects requiring drug withdrawal, and refractory cases. Hence, many researchers have redirected efforts towards investigation of other biological aspects of RA, including the mechanisms driving joint tissue repair and balanced immune regulation. This investigation focuses on mesenchymal stem cell (MSC) research, with the ultimate goal of developing interventions for immune modulation and repair of damaged joints. MSCs are multipotent cells capable of differentiating into mesodermal lineage cells. These cells have also attracted interest for their anti-inflammatory and immunomodulatory capacities. They have many distinctive immunological properties, inhibiting the proliferation and production of cytokines by T, B, natural killer, and dendritic cells. Indeed, MSCs have the capacity to regulate immunity-induced peripheral tolerance, suggesting they can be used as therapeutic tools in RA. This review discusses properties of MSCs, in vitro studies, animal studies, and clinical trials involving MSCs. Our review discusses the current knowledge of the mechanisms of MSC-mediated immunosuppression and potential therapeutic uses of MSCs in RA. (
Effect of Para-Aminobenzoic Acid on the Course of Retinal Degeneration in the rd10 Mouse (2009)

PABA treatment may protect retinal function and attenuate the course of retinal degeneration in rd10 mice. Biochemical parameters indicate a lower degree of oxidative injury in PABA-treated retinas. PABA may potentially serve as an addition to antioxidative treatment for retinal and macular degenerations.
Vapor-liquid equilibriums in binary aromatic-olefin systems (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVapor-liquid equilibriums in binary aromatic-olefin systemsJohn M. Prausnitz and Juan H. VeraCite this: J. Chem. Eng. Data 1971, 16, 2, 149–154Publication Date (Print):April 1, 1971Publication History Published online1 May 2002Published inissue 1 April 1971https://pubs.acs.org/doi/10.1021/je60049a012https://doi.org/10.1021/je60049a012research-articleACS PublicationsRequest reuse permissionsArticle Views119Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts