gebhart/patrepeval huggingface dataset:
In Vitro and In Vivo Comparison of the Activity of Human Lymphokine-Activated Killer (LAK) Cells and Adherent LAK Cells (1991)

The effectiveness of "standard" lymphokine-activated killer (LAK) cells, recovered after 6 days, and of "standard" adherent LAK (A-LAK) cells, recovered after 14 days of culture in the presence of recombinant interleukin-2 (rIL-2) from peripheral blood lymphocytes of 21 healthy donors, was assessed through comparison of their proliferation, surface markers, cytotoxic activity, lymphokine production, and antitumor activity. In the presence of rIL-2, plastic adherent precursors of A-LAK cells proliferated much better than those of "standard LAK" cells and expanded even more than 300-fold. However, the final cell recovery of A-LAK was always lower because of their very few precursors, and the total lytic units (LUs) generated in A-LAK cultures were always lower for the same reason. On the other hand, the lytic activity of each A-LAK cell was always higher than that of a LAK cell. This was particularly evident on day 6 of culture. Removal of nonadherent cells after the first 24 h culture resulted in a significant enrichment in CD3-CD56+ and CD8+CD56+ cells in A-LAK cells, with a marginal number of CD4+ cells. A significant direct correlation between LUs and A-LAK CD3-CD56+ percentage was found. In the presence of rIL-2, A-LAK cells produced higher amounts of tumor necrosis factor-alpha and interferon-gamma than LAK cells, while only A-LAK cells produced IL-1 beta and small amounts of IL-4. Neither LAK nor A-LAK produced IL-2. In the absence of injections of IL-2, LAK and A-LAK cells were equally able to inhibit the growth of a human T-cell lymphoma in immunosuppressed nude mice.
T2‐prepared SSFP improves diagnostic confidence in edema imaging in acute myocardial infarction compared to turbo spin echo (2007)

T2-weighted MRI of edema in acute myocardial infarction (MI) provides a means of differentiating acute and chronic MI, and assessing the area at risk of infarction. Conventional T2-weighted imaging of edema uses a turbo spin-echo (TSE) readout with dark-blood preparation. Clinical applications of dark-blood TSE methods can be limited by artifacts such as posterior wall signal loss due to through-plane motion, and bright subendocardial artifacts due to stagnant blood. Single-shot imaging with a T2-prepared SSFP readout provides an alternative to dark-blood TSE and may be conducted during free breathing. We hypothesized that T2-prepared SSFP would be a more reliable method than dark-blood TSE for imaging of edema in patients with MI. In patients with MI (22 acute and nine chronic MI cases), T2-weighted imaging with both methods was performed prior to contrast administration and delayed-enhancement imaging. The T2-weighted images using TSE were nondiagnostic in three of 31 cases, while six additional cases rated as being of diagnostic quality yielded incorrect diagnoses. In all 31 cases the T2-prepared SSFP images were rated as diagnostic quality, correctly differentiated acute or chronic MI, and correctly determined the coronary territory. Free-breathing T2 prepared SSFP provides T2-weighted images of acute MI with fewer artifacts and better diagnostic accuracy than conventional dark-blood TSE.
Operating experience in refinery application of the 13MW-class heavy duty MF-111 gas turbine engine (1990)

A new, 13MW class, heavy duty gas turbine, the “MF-111” was developed for use as a prime mover for cogeneration, combined cycle and repowering applications. The use of such equipment in refineries presents special challenges as regards the combustion of nonstandard fuels, tolerance of industrial environments, and accomodation of site-specific design requirements. Such circumstances add substantially to the tasks of proving and adjusting the design of a new gas turbine, meeting stringent emissions requirements and introducing to the world of industrial gas turbines the benefits of F-class (1250°C burner outlet temperature) levels of thermodynamic performance.This paper describes how these challenges have successfully been met during the three calendar years and ten machine-years of MF-111 refinery-application experience accumulated to-late.Copyright © 1990 by ASME
Structure of epitaxial SrIrO3 perovskite studied by interference between X-ray waves diffracted by the substrate and the thin film (2017)

A high-pressure metastable orthorhombic phase of SrIrO 3 perovskite has been epitaxially stabilized on several substrates (DyScO 3 , GdScO 3 , NdScO 3 and SrTiO 3 ) in the form of thin monocrystalline layers with (110) surface orientation. The unit-cell parameters of the pseudomorphic thin SrIrO 3 layers depend on the biaxial strain imposed by the various substrates due to the different lattice mismatches of the particular substrate and the bulk orthorhombic SrIrO 3 structure. Using X-ray diffractometry, it is shown that both compressive and tensile strain increase the lattice parameters a and b , while the angle γ scales with the applied strain, being smaller or larger than 90° for compressive or tensile strain, respectively, resulting in a small monoclinic distortion of the layer unit cell. Owing to the similarity of the substrate and layer lattices, the diffraction signals from the two structures overlap partially, which complicates structure determination by standard refinement methods using measured integrated intensities. The measured signal is composed of two interfering components corresponding to the waves diffracted by the substrate and by the layer, where the first component is calculated exactly using the known substrate structure, while the second one is determined by the unknown unit-cell parameters of the layer. The unit-cell parameters were refined in order to fit the experimental data with the simulation. The fractional coordinates of the atoms in the unit cell resulting from the fit are similar to those in the bulk structure.
A Neural Network Implementation Of A Permutation Decoder For Binary Cyclic Codes (2005)

In this paper we consider the decoding of binary cyclic block codes utilizing a permutation decoding technique based on a Hopfield type neural network architecture. It is well known that the maximum likelihood decoding of an $ n,k,t) :: binary hear code is equivalent to finding the minimum of a polynomial orm in k blnary vambles [ 11, (31. Using results from the work of Baldi [2], we show that a generalized Hopfield neural network whose connections are governed by the generator matrix of the code and the received word has a stable state corresponding to the transmitted codeword if? or fewer errors are introduced in the transmission process. An energy function is defined and is the basis of the updating of the network operating in serial mode. It is shown that changes to the state of the network based on a local improvement algorithm results in a lowering of the corresponding energy of the network and hence a descent in the energy space towards the codeword. If the codeword corresponding to the state of the network is within the Hamming energy sphere of the received word, then successful decoding has been achieved otherwise a permutation is applied to the received word and the process is repeated. This provides a useful mechanism for handling the local minimum problem which plagues optimization problems. We discuss the conditions under which the state will converge to the right codeword in the presence of random errors. We present a detailed algorithm for updating the state of the network and simulation results for non-trivial cyclic codes such as the (63,30,6) and (127,64,10) BCH codes. Summan,
Jones matrix and S-parameter analysis using an equivalent circuit model for intrinsically dual circularly polarized microstrip antennas (2015)

An equivalent circuit model is developed for intrinsically dual circularly polarized microstrip patch antennas. The circuit model can be tuned to represent a wide variety of antenna configurations and agrees well with full wave simulations of example antennas. Based on the model, we analyze cross polarization performance in terms of the Jones matrix and S-parameters and provide insight into the tradeoff between cross polarization performance and S-parameters.
Passive IgE‐sensitization by blood transfusion (2005)

Transfused IgE antibodies will sensitize mast cells and basophils to CD-sens levels similar to those of allergic patients. The recipients expressed 'slow' or 'rapid' CD-sens decline, indicating two different basophil populations. After transfusion of plasma with >10 kU(A)/l IgE antibody the recipient could have allergen reactive basophils for up to 7 weeks.
A New Approach To Smooth Shifting: Electro-Hydraulic Feedback Control For Automatic Transmissions (1988)

&lt;div class="htmlview paragraph"&gt;A. closed loop control system has been developed to minimize vehicle acceleration fluctuation during power-on upshift of an automatic transmission. This system senses the revolution speed of torque converter turbine runner, and controls the hydraulic pressure of clutch actuating cylinder during the shift sequence using a linear solenoid type electro-hydraulic pressure modulation valve so as to regulate the turbine runner speed on schedule.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;By the torsional rigidity of drive train, shorter torque phase brings smoother shifting. Opposing requirement exist to complete the torque phase quickly and to carefully limit clutch torque capacity. Discernment of clutch facing contact using pressure sensors is able to satisfy the requirement.&lt;/div&gt;
Supplementary Figure S1 from Radiation-Induced Amplification of TGFB1-Induced Mesenchymal Stem Cell–Mediated Sodium Iodide Symporter (<i>NIS</i>) Gene <sup>131</sup>I Therapy (2023)

&lt;p&gt;Supplementary Figure S1. Cell viability after EW-7197 treatment. The viability of SMAD-NIS-MSCs was not affected by treatment with different concentrations of the selective TGFB signaling inhibitor EW-7197 with or without 10 ng/ml TGFB1 for 24 h as determined by MTT assay. Data are presented as percent of untreated controls from four independent experiments (means {plus minus} SEM).&lt;/p&gt;
Reduction of the Nonspecific Binding of a Target Antibody and of Its Enzyme-Labeled Detection Probe Enabling Electrochemical Immunoassay of an Antibody through the 7 pg/mL−100 ng/mL (40 fM−400 pM) Range (2005)

We describe a simple, potentially low-cost, amperometric, enzyme-amplified, sandwich-type immunoassay, monitoring IgG at a concentration as low as approximately 7 pg/mL with a dynamic range of 10(4). The assay utilizes a screen-printed carbon electrode on which a redox hydrogel and avidin are co-electrodeposited. To neutralize nonspecifically binding positively charged microdomains of the avidin, two polyanions, poly(acrylic acid-co-maleic acid) and poly(acrylic acid), are applied. These polyanions bind to the film not only electrostatically but also by Michael addition reaction to cysteine, lysine, or arginine functions of the avidin. The electrode is then made specific for the analyte, for which rabbit IgG was chosen, by conjugating the film-bound avidin to biotin-labeled anti-rabbit IgG. After exposure to the tested solution and capture of rabbit IgG, the sandwich is completed by conjugation of horseradish-peroxidase (HRP)-labeled anti-rabbit IgG. Electrical contact between the HRP and the electrode-bound hydrogel results in the formation of an electrocatalyst for the electroreduction of H2O2 to water. The application of the poly(acrylic acid-co-maleic acid) and the poly(acrylic acid) reduces the nonspecific adsorption-associated noise, lowers the detection limit from 3 ng/mL (approximately 20 pM analyte antibody concentration) to approximately 7 pg/mL (approximately 40 fM analyte antibody concentration), and also expands the dynamic range to 10(4).
Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels. (2013)

VOLUME 277 (2002) PAGES 18881–18890 PAGE 18883: During preparation of the manuscript, the same images of yeast colonies were inadvertently shown for two different wild type controls in Fig. 2A. The panel is for visual purposes only. The quantification of three independent experiments is shown in Fig. 2B. The error does not affect the results or conclusions of the study.
Metal catecholato complexes: a source for metallo-labeling antigens (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetal catecholato complexes: a source for metallo-labeling antigensOttavio Gandolfi, Giuliano Dolcetti, Mauro Ghedini, and Michael CaisCite this: Inorg. Chem. 1980, 19, 6, 1785–1791Publication Date (Print):June 1, 1980Publication History Published online1 May 2002Published inissue 1 June 1980https://pubs.acs.org/doi/10.1021/ic50208a072https://doi.org/10.1021/ic50208a072research-articleACS PublicationsRequest reuse permissionsArticle Views109Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Hand-held thermal-regulating fluorometer (2005)

This article relates to the construction of a portable, low cost, thermal-regulating light-emitting diode (LED)-based, handheld fluorometer. This regulated fluorometer is based on both a low thermal mass infrared heater, and an orthogonal geometry LED-based filter fluorometer. Power is supplied through an external power supply and data is collected in real time through standard serial interfaces of personal computers or personal digital assistants. Thermal regulation is automatically maintained using temperature sensor feedback control. Optical excitation relies on LED light source(s) and optical detection is made through an adjustable integrating photodetector. With such a handheld system, applications requiring temperature sensitive photometric measurements for real-time analyte detection can be more easily performed in the field.
<title>Overview of the HST optical systems performance</title> (1993)

Soon after first light, it was discovered that the Hubble Space Telescope (HST) could not be brought to its optimum design focus. In a brief historical review, this paper tells how the spherical aberration was uncovered and quantified by independent review teams throughout the first year of observatory operation.
Acrocephalosyndactyly Syndromes (1997)

Over the last quarter century, a revision has taken place in the classification of the acrocephalosyndactyly syndromes. This reflects the advances in molecular biology that have led to improved genetic mapping of these syndromes. In this review we provide an overview of these major acrocephalosyndactyly syndromes, including the current classification system. The craniofacial, neurological, cardiac, pulmonary, visceral, and extremity anomalies are discussed with special emphasis on hand anomalies. Hand reconstruction techniques, including specific surgical procedures, the timing of the surgical reconstruction, and postoperative therapy are discussed. The need for coordinated care of the multidisciplinary disorders of these patients cannot be overemphasized, especially in the perioperative period.
Syntheses of Tyrosyltyrosyltyrosine and Tyrosyltyrosyltyrosyltyrosine (1944)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSyntheses of Tyrosyltyrosyltyrosine and TyrosyltyrosyltyrosyltyrosineArchie E. Barkdoll and William F. RossCite this: J. Am. Chem. Soc. 1944, 66, 6, 951–956Publication Date (Print):June 1, 1944Publication History Published online1 May 2002Published inissue 1 June 1944https://pubs.acs.org/doi/10.1021/ja01234a034https://doi.org/10.1021/ja01234a034research-articleACS PublicationsRequest reuse permissionsArticle Views108Altmetric-Citations34LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Theory of microphase separation in bidisperse chiral membranes (2016)

We present a Ginzburg-Landau theory of micro phase separation in a bidisperse chiral membrane consisting of rods of opposite handendness. This model system undergoes a phase transition from an equilibrium state where the two components are completely phase separated to a microphase separated state composed of domains of a finite size comparable to the twist penetration depth. Characterizing the phenomenology using linear stability analysis and numerical studies, we trace the origin of the discontinuous change in domain size that occurs during this to a competition between the cost of creating an interface and the gain in twist energy for small domains in which the twist penetrates deep into the center of the domain.
Tissue reactivity of monoclonal antibodies to human urothelial cell lines (1985)

Conference Article| February 01 1985 Tissue reactivity of monoclonal antibodies to human urothelial cell lines JOHN B. MATTHEWS; JOHN B. MATTHEWS *Departments of Oral Pathology, University of Birmingham, P.O. Box 363, Birmingham B15 2TT, U.K. Search for other works by this author on: This Site PubMed Google Scholar JENNIFER SOUTHGATE; JENNIFER SOUTHGATE ‡Departments of Imperial Cancer Research Fund, Lincoln's Inn Fields, London WC2A 3PX, U.K., University of Birmingham, P.O. Box 363, Birmingham B15 2TT, U.K. Search for other works by this author on: This Site PubMed Google Scholar GISELE M. HODGES; GISELE M. HODGES ‡Departments of Imperial Cancer Research Fund, Lincoln's Inn Fields, London WC2A 3PX, U.K., University of Birmingham, P.O. Box 363, Birmingham B15 2TT, U.K. Search for other works by this author on: This Site PubMed Google Scholar GILLIAN M. LAWRENCE; GILLIAN M. LAWRENCE †Departments of Biochemistry, University of Birmingham, P.O. Box 363, Birmingham B15 2TT, U.K. Search for other works by this author on: This Site PubMed Google Scholar LUDWIK K. TREJDOSIEWICZ LUDWIK K. TREJDOSIEWICZ §Department of Medicine, St. James's University Hospital, Leeds LS9 7TF, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1985) 13 (1): 122–123. https://doi.org/10.1042/bst0130122 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation JOHN B. MATTHEWS, JENNIFER SOUTHGATE, GISELE M. HODGES, GILLIAN M. LAWRENCE, LUDWIK K. TREJDOSIEWICZ; Tissue reactivity of monoclonal antibodies to human urothelial cell lines. Biochem Soc Trans 1 February 1985; 13 (1): 122–123. doi: https://doi.org/10.1042/bst0130122 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1985 Biochemical Society1985 Article PDF first page preview Close Modal You do not currently have access to this content.
Biochemical Characterization of the ATPase and Helicase Activity of UAP56, an Essential Pre-mRNA Splicing and mRNA Export Factor (2007)

DEXD/H-box protein UAP56 is an essential pre-mRNA splicing factor required for the first ATP-dependent spliceosome assembly step. UAP56 is also essential for the export of the majority of mRNAs from the nucleus to the cytoplasm. We performed biochemical characterization of UAP56's ATPase and helicase activity, which is important for further understanding the role of these activities in UAP56's function. We showed that UAP56 is an RNA-stimulated ATPase that can only hydrolyze ATP. We demonstrated that UAP56 is an ATP-dependent RNA helicase that can unwind substrates with 5' or 3' overhangs or blunt ends in vitro. We showed that U2AF(65) and Aly, two proteins known to interact with UAP56, do not influence UAP56's ATPase or helicase activity. We also demonstrated that several mutants in the conserved helicase motifs I, II, and III abolish UAP56's ATPase and/or helicase activity, providing tools for future investigation of the role of UAP56's ATPase and helicase activity in spliceosome assembly and mRNA export.
Two clinical isolates and the Toledo strain of cytomegalovirus contain endothelial cell tropic variants that are not present in the AD169, Towne, or Davis strains (1999)

The highly fibroblast-passaged AD169, Towne, and Davis strains of cytomegalovirus (CMV) were found to have a restricted capacity to infect endothelial cells in vitro. Although such replication could be increased by a combination of low speed centrifugation and sodium butyrate treatment, the extracellular virus produced was infectious for fibroblasts but not for endothelial cells. In contrast, the low passage Toledo strain, and a low passage fibroblast-grown clinical isolate of CMV, C1F, could be continually passaged in endothelial cells, giving the strains C1FE and Toledo.E. Whilst, using the conditions described above, initial infection of endothelial cells with AD169 or C1F resulted in similar titres of extracellular virus as assayed on fibroblasts, only the virus from the C1F strain was infectious for endothelial cells. Passage of C1F in fibroblasts decreased its ability to infect endothelial cells, whilst retaining equal ability to infect fibroblasts. Although endothelial-cell-passaged cell-free C1FE virus was endothelial cell-tropic, it was still much more infectious for fibroblasts than for endothelial cells. It is concluded that the C1F and Toledo strains, but not the AD169, Towne, or Davis strains, contained endothelial cell tropic variants, which could be lost on passage through fibroblasts, but retained on passage through endothelial cells. Furthermore, virus in an ex vivo source of CMV, a blood specimen, was found to be more tropic for fibroblasts than for endothelial cells, suggesting that in vivo CMV exists as quasi strains with different cell tropism, some of which might be lost in vitro by passage in an inappropriate cell type.
[Effect of the national lifestyle modification project conducted in Japan on the parameters of metabolic syndrome]. (2015)

Although HbA1c at the 1-year evaluation and parameters related to overweight were improved at the 1-, 2-, and 3-year evaluations, no parameters of metabolic syndrome were significantly improved by the guidance at the 4-year evaluation.
Cyperus strigosus L. (2003)

https://thekeep.eiu.edu/herbarium_specimens_byname/10547/thumbnail.jpg