gebhart/patrepeval huggingface dataset:
Breast cancer stratification from analysis of micro-array data of micro-dissected specimens. (2007)

We describe a new method based on principal component analysis and robust consensus ensemble clustering to identify and elucidate the subtypes of breast cancer disease. The method was applied to microarray gene expression data using micro-dissection of samples from 36 breast cancer patients with at least two of three pathological stages of disease. Controls were normal breast epithelial cells from 3 disease free patients. Our method identified an optimum set of genes and strong, stable clusters which correlated well with clinical classification into Luminal, Basal and Her2+ subtypes based on ER, PR and Her2 status. It also revealed a hierarchical portrait of disease progression through various grades and stages and identified genes and functional pathways for each stage, grade and disease subtype. We found that gene expression heterogeneity across subtypes is much greater than the heterogeneity of progression from DCIS to IDC within a subtype, suggesting that the disease subtypes are distinct disease processes. The averaging over data perturbations and clustering methods is critical in the robust identification of subtypes and gene markers for grade and progression.
Effect of DC-CIK cell on the proliferation, apoptosis and differentiation of leukemia cells (2014)

Co-culture of DC-CIK cells led to a significant increase of the proliferation and cytotoxicity of CIK.
Up‐regulated recombination‐activating gene expression in slg− variants of a human mature B cell line undergoing secondary Igλ, rearrangements in cell culture (1993)

To study the role of surface immunoglobulin (sIg) expression in the control of rearrangement activity at the Ig light chain loci, we established rare sIg- clones (lambda-) from a human sIg+ B cell line (mu lambda+). Upon expansion of these sIg- clones, surface immunofluorescence analysis revealed a gradual emergence of sIg+ subpopulations, differing from the original tumor cell line both in their idiotypes and C lambda isotypes. DNA analysis revealed that this sIg heterogeneity resulted from a process of ongoing Ig lambda rearrangements. That is, one of the Ig lambda rearrangements in the parental cell line was replaced by novel Ig lambda rearrangements in the sIg- clones, which in turn were replaced by yet additional Ig lambda rearrangements in the sIg+ variants. Northern analysis demonstrated that while the expression of the recombination-activating genes RAG1 and RAG2 was relatively low in the parental cell line, their expression was significantly increased in both the sIg- variants and their sIg+ progenies. We thus describe a human mature B cell line, in which differential RAG expression allows sIg heterogeneity to be generated through secondary Ig lambda gene rearrangements. Our results indicate that the induction of RAG expression may be inversely associated with sIg expression, but that sIg expression, alone, is not sufficient to down-regulate this expression.
ChemInform Abstract: SYNTH. UND EINIGE EIGENSCHAFTEN VON O‐ACYL‐ UND O‐NITROPHENYLHYDROXYLAMINEN (1973)

Abstract Aus. dem Äthylhydroxamat (I) erhält man über (II) und (III) die O‐substituierten Hydroxylarnine, z.B. (IVa)‐(IVc), deren Fähigkeit zur Aminierung von Tributylamin (V), Pyridin (VII), Diphenylsulfid (IX), Diphenylsulfoxid (XI) und Tnphenylphosphin (XIII) vergleichend untersucht wird.
SWIR and MIR emission and detection using an all-group IV platform (Conference Presentation) (2020)

Sn-containing group IV semiconductors (Si)GeSn represent a versatile platform to implement a variety of Si-compatible photonic, optoelectronic, and photovoltaic devices. This class of semiconductors provides two degrees of freedom, strain and composition, to tailor the band structure and lattice parameter thus laying the groundwork to implement novel heterostructures and low-dimensional systems on a Si substrate. In this presentation, we will discuss the recent progress in controlling and understanding the opto-electronic properties of metastable (Si)GeSn semiconductor nanowires and heterostructures. We will shed new light on the basic mechanisms governing their epitaxial growth and thermal stability. We will also discuss the opto-electronic properties and present strategies to integrate these material systems in the fabrication of short wavelength infrared (SWIR) and mid-infrared (MIR) detectors and light emitting devices.
Longitudinal optical phonon–plasmon coupling in luminescent 3C–SiC nanocrystal films (2010)

Glycerol-passivated 3C-SiC nanocrystal (NC) solid films with tunable blue photoluminescence show abnormal longitudinal optical (LO) phonon behavior. As the NC size increases, the LO phonon intensity increases in the Raman spectra of the solid films and is even larger than that of the transverse optical mode. The Raman spectra cannot be fitted by using only the phonon confinement model. When further considering the coupling between the LO phonon and plasmon induced by the surface deformation potential in the glycerol layer, good agreement is achieved between the experiments and theory. This indicates that the coupled LO phonon-plasmon effect arising from the surface bonding structure plays a crucial role in the modified LO phonon behavior.
Miniaturized Circularly Polarized Patch Antenna for RFID System (2018)

This paper presents a design of a miniaturized patch antenna with a Dumbbells-defected ground structure (DGS) for radio frequency identification (RFID) system in European ultra-high frequency (UHF) band. The comparative study of the patch antenna with and without DGS is presented. The effect of the number of DGS on the performance of the antenna is also studied. An antenna size reduction of 31% and an enhancement of 71% in realized gain are achieved as compared with the performance of the antenna without DGS. The antenna is fabricated and measured experimentally to validate the simulation results.
Web accessibility support for visually impaired users using link content analysis (2013)

Web pages are used for a variety of purposes. End users must understand dynamically changing content and sequentially follow page links to find desired material, requiring significant time and effort. However, for visually impaired users using screen readers, it can be difficult to find links to web pages when link text and alternative text descriptions are inappropriate. Our method supports the discovery of content by analyzing 8 categories of link types, and allows visually impaired users to be aware of the content represented by links in advance. This facilitates end users access to necessary information on web pages. Our method of classifying web page links is therefore effective as a means of evaluating accessibility.
Defective Calcium Influx Factor Activity in Neutrophils From Patients With Localized Juvenile Periodontitis (2000)

This study suggests that CIF activity may be an important determinant in neutrophil abnormalities in LJP.
L'économie française en 1987 (1988)

La economia francesa en 1987 : Crecimiento moderado - En un contexto international caracterizado por un crecimiento del 3 % para los paises de la OCDE, el Producto interior bruto de la economia francesa aumentó en un 2,2 %, a un ritmo comparable al de 1986, habiendo sido superior al de la República Federal de Alemania (1.7%). La distribución de la renta nacional continua desplazandose en beneficio de las empresas y en desmedro de los asalariados. A pesar de un levé incremento del poder adquisitivo, los hogares siguen privilegiando el consumo, sobre todo el de bienes duraderos, haciendo uso para ello de sus ahorros. Las empresas cuyo margen de beneficio vuelve a situar en el nivel que ocupaba en el periodo anterior al primer choque petrolero, aceleran sus inversiones. El vigor de la demanda interna y la tendencia continua a las perdidas en volumen de partes de mercado en el sector de la exportation acarrea el deteriora de los intercambios exteriores. El saldo de lastransacciones corrientes corre parejo con el déficit (— 23,3 mil millones de francos) principalmente a causa de los intercambios industriales cuyo saldo es negativo por primera vez desde 1969.
Does the understanding of immune activation by RNA predict the design of safe siRNAs? (2008)

The innate immune system uses pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs) to recognize conserved pathogen-associated molecular patterns (PAMPs) expressed by microbes and to activate the initial phase of immune response. Both bacterial and viral nucleic acids activate TLRs resulting in cytokines and interferon production. Recent studies indicated that unmodified small interfering RNAs (siRNAs) corresponding to either mammalian (self) or microbial (non-self) RNA sequences can activate immunity through TLR7/8 in a sequence-dependent manner. Hence, the use siRNAs in humans will require understanding the mechanisms involved in the discrimination between self and non-self RNAs. In the case where immunostimulation is not wanted, chemical modifications can prevent immune activation and reduce off-target effects, while preserving siRNA silencing potency. Interestingly, 2'-O-methyl modified RNAs not only evade immune sensing, but antagonize with immunostimulatory single- or double-stranded siRNAs to activate innate immunity. This review highlights the recent progress in understanding the siRNA sensing by innate immunity and presents a range of strategies allowing either the design of siRNAs with minimal or maximal immunostimulatory potency for therapeutic applications.
RAD51 supports spontaneous non-homologous recombination in mammalian cells, but not the corresponding process induced by topoisomerase inhibitors (2001)

The RAD51 protein has been shown to participate in homologous recombination by promoting ATP-dependent homologous pairing and strand transfer reactions. In the present study, we have investigated the possible involvement of RAD51 in non-homologous recombination. We demonstrate that overexpression of CgRAD51 enhances the frequency of spontaneous non-homologous recombination in the hprt gene of Chinese hamster cells. However, the rate of non-homologous recombination induced by the topoisomerase inhibitors campothecin and etoposide was not altered by overexpression of RAD51. These results indicate that the RAD51 protein may perform a function in connection with spontaneous non-homologous recombination that is not essential to or not rate-limiting for non-homologous recombination induced by camptothecin or etoposide. We discuss the possibility that the role played by RAD51 in non-homologous recombination observed here may not be linked to non-homologous end-joining.
The Wings of the Dove (2009)

The vivacious Kate Croy seems to face a stark choice; to marry Merton Densher, the impoverished journalist she loves, and thereby break with her family, or to marry lovelessly but well and take up her rightful place in the society. Kate Croy is already romantically involved with promising journalist Merton when they become acquainted with Milly Theale, a New York socialite of immense wealth. Despite that fabulous wealth, Milly Theale is as alone in the world as a fairytale princess. Learning of Milly’s mortal illness and passionate attraction to Densher, Kate sets the scene for a romantic betrayal intended to secure her lasting financial security. Taking in the drawing rooms of London and the opulence of Venice, this is one of Henry James’ most dramatic and poignant commentaries on society and women’s place within it.
Minitutorial: Integrated optoelectronics (1987)

The ever increasing need for higher bandwidth transmission of data among terminals, circuit boards, and even between electronic circuits contained on a single chip has provided increasing motivation for the systems designer to utilize sophisticated optical interconnect technology. As the complexity of such optical systems Increases, there is a concomitant need for a higher level of integration of the electronic and photonic circuit segments on a single chip since such components have the potential for providing increased functionality and performance at a lower cost than do their hybrid counterparts. This paper focuses on the several challenges now confronting researchers attempting to fabricate building-block monolithic components. The various materials technologies and the particular devices attracting the greatest interest are considered. In particular, optical receivers, which have long been considered an essential device for many generic systems applications, are discussed.
Entanglement witness on a programmable photonic processor (2021)

Multiphoton quantum interference is a one of the two technology platforms in which a quantum advantage has been demonstrated [1]. In these systems, a large-scale quantum state forms due to repeated effective interactions of photons (through the generalized Hong-Ou-Mandel effect) at the nodes of a photonic processor, resulting in a state that intrinsically possesses quantum complexity. A key question is how to validate the formation of a large-scale quantum state. One aspect of this is to measure whether the output quantum state is entangled – a necessary but not sufficient criterion for complexity. In this work, we derive and demonstrate an entanglement witness for large-scale optical quantum interference, and experimentally use this to demonstrate the presence of entanglement in our optical processor [2]. [1] Zhong et al., Science 370, 1460 – 1463 (2020) [2] Taballione et al., ArXiv 2012.05673 (2021)
Implementing the Lexical Approach: Putting Theory into Practice (1997)

1. What is the Lexical Approach? 2. Understanding Lexis 3. Lexis in the Classroom 4. The Role of L1 in the Lexical Approach 5. Organizing Lexis 6. Exercises in the Lexical Approach 7. Adapting Activities in the Lexical Approach 8. Classroom Reports 9. Language Content 10. Teachers and Teacher Training 11. What Next?
Nine‐month results of the REFORM study (2012)

Objectives To evaluate the 9‐month safety and effectiveness outcomes of the Formula™ balloon‐expandable renal stent (Cook Medical, Bloomington, IN) for the treatment of atherosclerotic renal artery stenosis (RAS) following suboptimal angioplasty. Background Atherosclerotic RAS can cause hypertension and ischemic nephropathy. When clinically indicated, an interventional approach with renal angioplasty and stent implantation is the preferred method for revascularization of atherosclerotic renal artery stenoses. Methods The REFORM study is a prospective, multicenter, single‐arm study of stent implantation following suboptimal PTRA using the Formula stent. One hundred patients with atherosclerotic ostial renal artery lesions =18 mm in length with a &gt;50% residual stenosis following PTA were enrolled. The primary endpoint was 9‐month primary patency. Results The 9‐month primary patency rate was 91.7%. The 9‐month major adverse event rate was 2.2%. Mean systolic blood pressure was significantly decreased at follow‐up (from 150 ± 21 mm Hg at baseline to 141 ± 21 mm Hg at 9 months; P = 0.003). Mean serum creatinine (SCr) level and mean estimated glomerular filtration rate (eGFR) were not significantly different at 9 months. A clinically meaningful improvement in renal function (i.e., =25% increase in eGFR or =0.5 mg/dl decrease in SCr) was observed in 9% of patients at 1 month and 12% of patients at 9 months. A clinically meaningful decline in renal function (i.e., =25% decrease in eGFR or =0.5 mg/dl increase in SCr) was observed in only 3% of patients at 1 month and 7% of patients at 9 months. Conclusions The Formula stent was safe and effective in treating atherosclerotic RAS following suboptimal angioplasty. © 2013 Wiley Periodicals, Inc.
A novel way to prepare ultra-thin polymer films through surface radical chain-transfer reaction (2001)

Radical chain transfer to bonded thiol groups and surface re-initiated polymerization resulted in ultra-thin polymer films.
Mucosal antibody responses to vaccines targeting SIV protease cleavage sites or full-length Gag and Env proteins in Mauritian cynomolgus macaques (2018)

HIV mutates rapidly and infects CD4+ T cells, especially when they are activated. A vaccine targeting conserved, essential viral elements while limiting CD4+ T cell activation could be effective. Learning from natural immunity observed in a group of highly HIV-1 exposed seronegative Kenyan female sex workers, we are testing a novel candidate HIV vaccine targeting the 12 viral protease cleavage sites (PCSs) (the PCS vaccine), in comparison with a vaccine targeting full-length Gag and Env (the Gag/Env vaccine) in a Mauritian cynomolgus macaque/SIV model. In this study we evaluated these vaccines for induction of mucosal antibodies to SIV immunogens at the female genital tract. Bio-Plex and Western blot analyses of cervicovaginal lavage samples showed that both the PCS and Gag/Env vaccines can elicit mucosal IgG antibody responses to SIV immunogens. Significantly higher increase of anti-PCS antibodies was induced by the PCS vaccine than by the Gag/Env vaccine (p<0.0001). The effect of the mucosal antibody responses in protection from repeated low dose pathogenic SIVmac251 challenges is being evaluated.
New mode of ligation for 1,3-butadiene to two metal centers. Synthesis and structure of [{(iso-Pr)2PCH2CH2CH2P(iso-Pr)2}Rh]2(.mu.-.eta.3-.eta.3-C4H6): a partial butadiene sandwich (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew mode of ligation for 1,3-butadiene to two metal centers. Synthesis and structure of [{(iso-Pr)2PCH2CH2CH2P(iso-Pr)2}Rh]2(.mu.-.eta.3-.eta.3-C4H6): a partial butadiene sandwichMichael D. Fryzuk, Warren E. Piers, and Steven J. RettigCite this: J. Am. Chem. Soc. 1985, 107, 26, 8259–8261Publication Date (Print):December 1, 1985Publication History Published online1 May 2002Published inissue 1 December 1985https://pubs.acs.org/doi/10.1021/ja00312a075https://doi.org/10.1021/ja00312a075research-articleACS PublicationsRequest reuse permissionsArticle Views110Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Extensive contacts between ADAMTS13 exosites and von Willebrand factor domain A2 contribute to substrate specificity (2008)

The metalloprotease ADAMTS13 efficiently cleaves only the Tyr(1605)-Met(1606) bond in the central A2 domain of multimeric von Willebrand factor (VWF), even though VWF constitutes only 0.02% of plasma proteins. This remarkable specificity depends in part on binding of the noncatalytic ADAMTS13 spacer domain to the C-terminal alpha-helix of VWF domain A2. By kinetic analysis of recombinant ADAMTS13 constructs, we show that the first thrombospondin-1, Cys-rich, and spacer domains of ADAMTS13 interact with segments of VWF domain A2 between Gln(1624) and Arg(1668), and together these exosite interactions increase the rate of substrate cleavage by at least approximately 300-fold. Internal deletion of Gln(1624)-Arg(1641) minimally affected the rate of cleavage, indicating that ADAMTS13 does not require a specific distance between the scissile bond and auxiliary substrate binding sites. Smaller deletions of the P2-P9 or the P4'-P18' residues on either side of the Tyr(1605)-Met(1606) bond abolished cleavage, indicating that the metalloprotease domain interacts with additional residues flanking the cleavage site. Thus, specific recognition of VWF depends on cooperative, modular contacts between several ADAMTS13 domains and discrete segments of VWF domain A2.
Plasma polymerization of styrene with controlled particle energy (1998)

A new type of reactor for plasma polymerization was developed in order to achieve an effective control of styrene polymerization process. Electrons and ions were extracted from the radio frequency (rf) glow discharge region to the downstream region to generate plasma polymerization. The energy of extracted ionized particles was controlled by the bias voltage of a screen grid unit. Deposited polymer thin films were analyzed by X-ray photoelectron spectroscopy (XPS) and infrared (IR) spectroscopy. The result showed that the polarity and energy of the extracted particles had considerable effect on the deposition rate and structure of the deposited films. At each bias polarity there was a maximum deposition rate vs. voltage magnitude, and the maximum at the positive voltage was higher. In addition, the bulk aromaticity of the film deposited at the negative bias was lower than at the positive bias; the surface aromaticity of the films was much higher than that of the films prepared by usual rf discharge. © 1998 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 36: 1265–1270, 1998
Dynamic susceptibility contrast MR imaging of plaque development in multiple sclerosis: Application of an extended blood-brain barrier leakage correction (2000)

Since the pathogenesis of multiple sclerosis (MS) lesions is not yet fully understood, we investigated the potential of dynamic susceptibility contrast (DSC) magnetic resonance (MR) perfusion imaging for a better characterization of lesion pathology. Twenty-five MS patients were examined on a 1.5 T scanner. A single dose of gadolinium (Gd)-DOTA contrast agent was injected, and echoplanar images were acquired every 0.5 seconds for 1 minute. From the signal intensity-versus-time curves, the relative cerebral blood volume (rCBV) was evaluated for regions in plaques and in gray and white matter. The rCBV calculated for acute, Gd-enhancing plaques was corrected for the effects of blood-brain barrier leakage, using a new correction algorithm. Acute plaques had significantly higher blood volumes than normal-appearing white matter (P < = 0.01). Chronic plaques that appeared hypointense on T(1)-weighted images had lower rCBV than T(1)-isointense plaques (P < = 0.03). Our results indicate that the acute phase in MS is accompanied by vasodilation. In later stages of gliosis, the perfusion decreases with increasing axonal injury. Although the DSC technique is less sensitive than conventional MR imaging, the information provided is essentially different from that obtained with any other MR method.
Tissue distribution and structure of barrier cells in the hematopoietic and lymphoid organs of salmonids (1996)

Our results demonstrate the presence of cells closely resembling mammalian barrier cells in the hematopoietic and lymphoid organs of salmonids. The structure and tissue distribution of the salmonid barrier cells are discussed in relation to the functional roles described for this cell type in mammals.
Some Thoughts on Regulating Food Safety in China (2006)

The article analyses the current situation of food safety supervision in China, summarizes the deep reason behind the food safety and puts forward some suggestions to strengthen the supervision by using foreign references and advance operations from the legislation, the food safety supervision system and other aspects.