gebhart/patrepeval huggingface dataset:
Environmental Sustainability Education At The University Of Michigan: Collaboration With Industry To Provide Experiential Learning Opportunities (2020)

The Concentrations in Environmental Sustainability (ConsEnSus) Program at the University of Michigan is a new multi-disciplinary opportunity for graduate students in the College of Engineering to pursue interests in environmental sustainability while obtaining a traditional engineering Master's degree. Students from several engineering departments complement traditional disciplinary course requirements with courses in environmental regulations, policies, and technology. A required case studies course of the ConsEnSus Program brings practicing engineers together with students to discuss real-world sustainability problems. The industrial participants interactively present relevant case studies, and provide opportunities for experiential learning through classroom activities and term projects. This paper will further explain the ConsEnSus Program, its implementation, the initial
Biologically active MK-801 and SKF-10,047 binding sites distinct from those in rat brain are expressed on human lung cancer cells. (1992)

We have shown previously that cultured human lung cancer cells of different histologic types express multiple opioid receptors that can regulate their growth. In this report, we show that these cells also express specific, saturable, and high-affinity binding sites (Kd approximately 1 nM) for the non-opioid phencyclidine (PCP), [(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,b]cyclohepten-5,10-imine hydrogen maleate] (MK-801) and sigma N-allylnormetazocine (SKF-10,047) receptor ligands. Characterization of these binding sites showed them to be protein in nature and sensitive to the guanine nucleotide GTP. Pharmacological studies showed that (+) MK-801 and (+) SKF-10,047 competed with each other for their binding sites and also for the methadone binding site present in these cells. However, the mu and delta opioid ligands did not compete for (+) MK-801 and (+) SKF-10,047 binding sites. In addition, these binding sites on lung cancer cells appear to be distinct from the N-methyl D-aspartate/PCP receptor ionophore complex reported to be present in rat brain. MK-801 and SKF-10,047, at nM concentrations, were found to inhibit the growth of these cells in culture within a few hours of exposure, and this effect was irreversible after 24 h. The growth effects of these ligands could not be reversed by the opioid antagonist naloxone, suggesting involvement of nonopioid type receptors in the actions of these ligands. The abundant expression of biologically active MK-801 and SKF-10 047 binding sites in these cell lines, distinct from those in rat brain, suggests that these cell lines may prove to be a valuable source for further characterization and purification of these binding sites.
A Four Stroke Camless Engine, Operated in Homogeneous Charge Compression Ignition Mode with Commercial Gasoline (2001)

&lt;div class="htmlview paragraph"&gt;A single cylinder, naturally aspirated, four-stroke and camless (Otto) engine was operated in homogeneous charge compression ignition (HCCI) mode with commercial gasoline. The valve timing could be adjusted during engine operation, which made it possible to optimize the HCCI engine operation for different speed and load points in the part-load regime of a 5-cylinder 2.4 liter engine.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;Several tests were made with differing combinations of speed and load conditions, while varying the valve timing and the inlet manifold air pressure. Starting with conventional SI combustion, the negative valve overlap was increased until HCCI combustion was obtained. Then the influences of the equivalence ratio and the exhaust valve opening were investigated. With the engine operating on HCCI combustion, unthrottled and without preheating, the exhaust valve opening, the exhaust valve closing and the intake valve closing were optimized next. Finally, with three valve timing events, an HCCI operational window was identified.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;Using only three valve timing events, an engine operational window for HCCI combustion was obtained with: a maximum load of about 3.5 bar, a minimum load of about 0.1 bar, a maximum speed about 3000 rpm, and a minimum speed about 1200 rpm. The window for HCCI combustion is restricted by zones of knock (on the high load part) and by cycle to cycle variations in cylinder pressure (on the low load part) at high and low engine speeds. Between HCCI combustion and conventional SI combustion, there is a transient interval during which a spark triggers the auto ignition. A clear benefit in reduced CO emissions, NOx emissions (close to zero), and fuel consumption was observed during HCCI engine operation, compared with conventional SI combustion whereas the level of hydrocarbon emissions was approximately the same. The EVC has the greatest influence on the HCCI auto-ignition delay for the engine operating parameters tested. The influence of EVO is controlled by the gas dynamics and IVC has only a minor effect on engine behavior.&lt;/div&gt;
Synthesis and Characterization of a Bis(μ-β-diketonato)bis((1,2,5,6-η)-1,5-dimethyl-1,5- cyclooctadiene)disilver Complex. An Intermediate in the Synthesis of an Isomerically Pure (β-Diketonato)((1,2,5,6-η)-1,5-dimethyl-1,5-cyclooctadiene)copper(I) Complex (1996)

Dimethyl-1,5-cyclooctadiene (DMCOD) is synthesized by the Ni-catalyzed dimerization of isoprene and consists of 80% 1,5-dimethyl-1,5-cyclooctadiene (1,5-DMCOD) and 20% 1,6-dimethyl-1,5-cyclooctadiene (1,6-DMCOD). Reaction of Hhfac (1,1,1,5,5,5-hexafluoro-2,4-pentanedione) with Ag(2)O in the presence of DMCOD results in the formation of isomeric Ag(I) species. Repeated recrystallizations yield an isomerically pure compound ((1,5-DMCOD)Ag(hfac))(2) that was characterized by X-ray crystallography and (1)H and (13)C NMR and IR spectroscopy. X-ray crystallography revealed a dinuclear complex with a short Ag-Ag spacing (3.0134(3) Å at -150 degrees C and 3.0278(5) Å at -20 degrees C) and bridging hfac ligands (&mgr;(2) bonding). The overall geometry around the Ag atoms is a deformed tetrahedron with two short Ag-O bonds (2.375 Å average) and two Ag-diene bonds. The methyl groups of the 1,5-DMCOD ligand are pointed toward the center of the molecule. Decomposition of the silver complex in a biphasic HCl (1 M)/CH(2)Cl(2) mixture liberates isomerially pure 1,5-DMCOD; this diene is subsequently used to synthesize isomerically pure (1,5-DMCOD)Cu(hfac). The latter compound was characterized by (1)H and (13)C NMR and IR spectroscopy and is a useful liquid precursor for Cu CVD. Crystallographic data: C(30)H(34)Ag(2)F(12)O(4), monoclinic, P2(1)/c (No. 14), Z = 4; at -150 degrees C, a = 12.428(1) Å, b = 11.071(1) Å, c = 24.520(2) Å, beta = 101.98(1) degrees; at -20 degrees C, a = 12.597(1) Å, b = 11.191(1) Å, c = 24.641(2) Å, beta = 102.08(1) degrees.
Relationship between age‐related hearing loss and consumption of coffee and tea (2023)

The data that support the findings of this study are available from the corresponding author upon reasonable request. Table S1. Characteristics of the study population and results of univariate analyses. Table S2. Correlation matrix among variables. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Prediction of the potentially fertile period by urinary hormone measurements using a new home-use monitor: comparison with laboratory hormone analyses (2001)

The system can provide couples attempting to conceive with information about the potentially fertile days in the cycle in order that they may time intercourse. It also has potential for use in evaluation and treatment of infertile couples.
TWENTY‐TWO CARBON HOMOLOGUE OF 11‐CIS RETINAL. PHOTOPHYSICAL AND PHOTOCHEMICAL PROPERTIES (1984)

Abstract— Results concerning absorption‐emission spectra and fluorescence quantum yields at 77 and 298K. triplet absorption spectra, and quantum yields of intersystem crossing and photoisomerization at 298 K, are presented for 11‐ cis β‐apo‐14′‐carotenal (C 22 ‐Ald), the immediate higher homologue of 11‐ cis retinal. The absorption spectra are characterized by two band‐systems with maxima at 390–400 and 270–280 nm, respectively. Upon cooling from 298 to 77 K, the intensities of these two band‐systems undergo changes in opposite directions indicating 12‐s‐ cis: 12‐ s‐trans conformational changes. No intermediate band‐system analogous to the one located at 270–310 nm in cis retinals is observed for 11‐ cis C 22 ‐Ald. In nonpolar hydrocarbon solvents (e. g. cyclohexane) at room temperature, quantum yields of fluorescence (0.01), intersystem crossing (0.6) and photoisomerization (0.4) are all quite pronounced. The photophysical and photochemical properties of 11‐ cis C 22 ‐Ald are discussed in the light of similarities and dissimilarities with those of all‐ trans C 22 ‐Ald and 11‐ cis retinal under comparable conditions.
Normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition (2002)

The signals that determine the correct polarity of breast epithelial structures in vivo are not understood. We have shown previously that luminal epithelial cells can be polarized when cultured within a reconstituted basement membrane gel. We reasoned that such cues in vivo may be given by myoepithelial cells. Accordingly, we used an assay where luminal epithelial cells are incorrectly polarized to test this hypothesis. We show that culturing human primary luminal epithelial cells within collagen-I gels leads to formation of structures with no lumina and with reverse polarity as judged by dual stainings for sialomucin, epithelial specific antigen or occludin. No basement membrane is deposited, and beta4-integrin staining is negative. Addition of purified human myoepithelial cells isolated from normal glands corrects the inverse polarity, and leads to formation of double-layered acini with central lumina. Among the laminins present in the human breast basement membrane (laminin-1, -5 and -10/11), laminin-1 was unique in its ability to substitute for myoepithelial cells in polarity reversal. Myoepithelial cells were purified also from four different breast cancer sources including a biphasic cell line. Three out of four samples either totally lacked the ability to interact with luminal epithelial cells, or conveyed only correction of polarity in a fraction of acini. This behavior was directly related to the ability of the tumor myoepithelial cells to produce alpha-1 chain of laminin. In vivo, breast carcinomas were either negative for laminin-1 (7/12 biopsies) or showed a focal, fragmented deposition of a less intensely stained basement membrane (5/12 biopsies). Dual staining with myoepithelial markers revealed that tumor-associated myoepithelial cells were either negative or weakly positive for expression of laminin-1, establishing a strong correlation between loss of laminin-1 and breast cancer. We conclude that the double-layered breast acinus may be recapitulated in culture and that one reason for the ability of myoepithelial cells to induce polarity is because they are the only source of laminin-1 in the breast in vivo. A further conclusion is that a majority of tumor-derived/-associated myoepithelial cells are deficient in their ability to impart polarity because they have lost their ability to synthesize sufficient or functional laminin-1. These results have important implications for the role of myoepithelial cells in maintenance of polarity in normal breast and how they may function as structural tumor suppressors.
Plasma-derived extracellular vesicle proteins as a source of biomarkers for lung adenocarcinoma (2017)

Exosomes and other extracellular vesicles (EVs) have been implicated as mediators of intercellular communication. Their release into the circulation has the potential to inform about tumor status. In-depth proteomic characterization of plasma-derived EVs has been limited by challenges in isolating EVs from protein-abundant biological fluids. We implemented a novel single-step density gradient flotation workflow for efficient and rapid isolation of highly enriched circulating EVs from plasma. Mass-spectrometry analysis of plasma EVs from subjects with lung adenocarcinoma and matched controls resulted in the identification of 640 proteins. A total of 108 proteins exhibited significant (<i>p</i><0.05) differential expression in vesicle preparations derived from lung adenocarcinoma case plasmas compared to controls, of which 43 were also identified in EVs from lung adenocarcinoma cell lines. Four top performing EV-associated proteins that distinguished adenocarcinoma cases from controls, SRGN, TPM3, THBS1 and HUWE1, yielded a combined area under the receiver operating characteristic curve (AUC) of 0.90 (95% CI = 0.76-1). Our findings support the potential of EV derived proteins as a source of biomarkers that complement other approaches for tumor assessment.
Monensin in Cattle: Introduction (1984)

To emphasize the significance of chemicals in modern animal production and to introduce discussion of agricultural chemical technology in this symposium, a few general comments are in order. It is well to emphasize the importance of animal products in the human food supply. Three factors are basic to meat production, in particular, to meat production from ruminant animals. These are: 1) a highly nutritious product, 2) a food product that can be produced from raw materials not otherwise usable as human food and 3) a strong product demand. The first two factors are critical relative to the challenge of matching worldwide resources to the future food requirements of a growing population and achieving the ability to adequately feed that population. Means of improving the conversion of raw materials to meat products through chemical manipulation are important technological resources. First, the quality of meat as a component of our diet has been summarized from the literature by Cunha (1982).
Analysis of kinematic data in pathological tremor with the Hilbert-Huang transform (2011)

This paper presents analysis of kinematic data of tremor patients while performing different tasks with Ensemble Empirical Mode Decomposition (EEMD), a novel noise-assisted data analysis method. EEMD automatically separates raw kinematic data into three components: 1) noise from various sources, 2) tremulous movement, and 3) voluntary movement. Comparison of this technique with other decomposition methods such as recursive forth and back filters or Empirical Mode Decomposition (EMD) shows a better performance; EEMD separation of tremor diminishes EMD error in a 45.2 % (mean error 0.041 ± 0.036 rad/s). Moreover, postprocessing of EEMD separated tremor allows the calculation of the Hilbert spectrum, a high resolution time-energy-frequency distribution that improves analysis of tremors.
Microwave‐assisted synthesis, metallation, and duff formylation of porphyrins (2009)

Abstract magnified image Microwave assisted synthesis, metallation, and β‐formylation of porphyrins is described. All synthetic reactions were carried out on inorganic polymer solid support using microwave energy. It is the first documented application of the Duff reaction in the field of porphyrins and metalloporphyrins. The overall process is simple, easy, and environment friendly. FTIR, UV–visible, elemental analysis, 1 H NMR, and mass spectrometry were used to characterize the compounds. J. Heterocyclic Chem., 46 , 251 (2009).
Cell cycle traverse in AHH-1tk +/− human lymphoblastoid cells exposed to the chromosomal mutagen,m-amsa (1996)

AHH-1 tk +/- cells were exposed to the chemotherapeutic agent, m-amsa, both in complete medium and in medium without serum, subcultured in complete medium, and the effect on the traverse of the cell cycle determined by flow cytometric analysis of bromodeoxyuridine (BrdUrd)-labeled DNA. After exposure to m-amsa (day 0), the percentage of S-phase cells increased significantly (P < 0.0017) with increasing concentration. Cells also accumulated in G2/M as evidenced by the significant (P < 0.0026), concentration-dependent increase in the percentage of cells detected within this phase. Serum deprivation during exposure resulted in significantly (P = 0.024) more cells in S-phase than in cultures exposed to m-amsa in complete medium. After three days in culture, a significant (P = 0.0001) accumulation of cells in G2/M was present; the percentage of cells in G2/M did not differ significantly (P = 0.148) in cultures exposed to m-amsa in complete medium or in serum-free medium. However, a significant (P < 0.001) loss of S-phase cells was found in cultures exposed without serum. At day 7, no significant concentration effects were detected (GO/G1, P = 0.6026; S-phase, P = 0.9773; G2/M, P = 0.8401). These results demonstrate that exposure to m-amsa perturbs the traverse of the cell cycle, initially by inhibiting the completion of S-phase and followed by an accumulation of cells in G2/M. In addition, exposure to m-amsa under conditions of serum deprivation results in an increased percentage of cells in the initial S-phase after exposure, the loss of S-phase cells from the culture after three days, and the appearance of subdiploid peak, consistent with cells undergoing apoptosis.
Chemistry of the copper-dithiooxalate complexes. Synthesis of a new carbonyl sulfide complex (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry of the copper-dithiooxalate complexes. Synthesis of a new carbonyl sulfide complexDimitri CoucouvanisCite this: J. Am. Chem. Soc. 1971, 93, 7, 1786–1788Publication Date (Print):April 1, 1971Publication History Published online1 May 2002Published inissue 1 April 1971https://doi.org/10.1021/ja00736a040RIGHTS & PERMISSIONSArticle Views179Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (364 KB) Get e-Alerts Get e-Alerts
Tea cream formation: The contribution of black tea phenolic pigments determined by HPLC (1993)

Abstract Reverse‐phase HPLC of liquors prepared from a Lattakari Assam black tea was used to assess the contribution of black tea phenolic pigments to ‘tea cream’, a precipitate which forms routinely following caffeine complexation of the phenols when a strong infusion of black tea cools. In this study caffeine was added back to tea liquor fractions and reconstituted decaffeinated whole tea liquor, and the extent to which the theaflavins, thearubigins and flavonol glycosides were removed from solution in the form of insoluble complexes was monitored by HPLC. The poorly characterised thearubigins are shown to be the principal (≈ 86%) pigmented phenolic components of ‘tea cream’. Theaflavins (≈ 12%) and flavonol glycosides (≈ 2%) were also present. Evidence is presented for a synergistic interaction between theaflavins and thearubigins during cream formation. The use of caffeine precipitation is proposed as an aid to the fractionation and quantification of phenols including thearubigins in black tea liquors.
Wafer-level three-dimensional monolithic integration for heterogeneous silicon ICs (2005)

A 3D IC technology platform is presented for high-performance, low-cost heterogeneous integration of silicon ICs. The platform uses dielectric adhesive bonding of fully-processed wafer-to-wafer aligned ICs, followed by a three-step thinning process and copper damascene patterning to form inter-wafer interconnects. Daisy-chain inter-wafer vias and compatibility of the process steps with 130 nm CMOS SOI devices and circuits indicate the viability of the process flow. Memory-intensive digital processors with large L2 caches have shorter access time and cycle time with 3D implementations. Performance advantages of recently designed SiGe BiCMOS pipelined A/D converters have promising figure-of-merits and illustrate partitioning issues for silicon RF ICs. Comparison with system-on-a-chip (SoC) and system-in-a-package (SiP) implementations is presented.
Assessment of Crystallinity Development during Fused Filament Fabrication through Fast Scanning Chip Calorimetry (2019)

Although semi-crystalline polymers are associated with considerably better mechanical properties and thermal stability compared to their amorphous counterparts, using them as feedstock for Fused Filament Fabrication still poses some major challenges. Hence, the development of printed part crystallinity during printing should be fully understood in order to control the developed weld strength, as well as part shrinkage and warpage. Infrared thermography was utilized to record the thermal history of deposited layers while printing a single-layer wall geometry, employing two PA 6/66 copolymers with distinct molecular weights as feedstock. Print settings were varied to establish which settings are essential to effectively monitor final part crystallinity. The resulting temperature profiles were simulated in a Fast Scanning Chip Calorimetry device that allows for the rapid heating and cooling rates experienced by the printed polymer. Both liquefier temperature and print speed were found to have very little influence on the total attained crystallinity. It became apparent that the build plate, set at a temperature above the polymer’s glass transition temperature, imposes a considerable annealing effect on the printed part. A reduced molecular weight was observed to enhance crystallinity even more strongly. The presented methodology proves that Fast Scanning Chip Calorimetry is an effective tool to assess the impact of both print parameters and feedstock characteristics on the crystallization behavior of semi-crystalline polymers over the course of printing.
Rough‐and‐tumble play as a window on animal communication (2015)

Rough-and-tumble play (RT) is a widespread phenomenon in mammals. Since it involves competition, whereby one animal attempts to gain advantage over another, RT runs the risk of escalation to serious fighting. Competition is typically curtailed by some degree of cooperation and different signals help negotiate potential mishaps during RT. This review provides a framework for such signals, showing that they range along two dimensions: one from signals borrowed from other functional contexts to those that are unique to play, and the other from purely emotional expressions to highly cognitive (intentional) constructions. Some animal taxa have exaggerated the emotional and cognitive interplay aspects of play signals, yielding admixtures of communication that have led to complex forms of RT. This complexity has been further exaggerated in some lineages by the development of specific novel gestures that can be used to negotiate playful mood and entice reluctant partners. Play-derived gestures may provide new mechanisms by which more sophisticated communication forms can evolve. Therefore, RT and playful communication provide a window into the study of social cognition, emotional regulation and the evolution of communication systems.