gebhart/patrepeval huggingface dataset:
Preparation of a β‐Phosphatrimethinecyanine Dye (1977)

The first β-phosphatrimethinecyanine dye has now been prepared as the tetrafluoroborate from a methyleneindoline derivative. The compound forms dark blue crystals.
The molecular basis of myocardial hypertrophy. (1994)

Myocardial hypertrophy is an adaptive response of the heart to several pathological situations aimed at maintaining adequate cardiac contractile function. This process is characterized by complex qualitative and quantitative changes of both cardiomyocytes and nonmyocyte cardiac cells. The initial stimulus inducing these cellular responses is parietal stretch subsequent to either a pressure or volume overload. Many substances locally produced and acting in a paracrine-autocrine fashion are involved in the response to stretch by cardiac cells. The stretch, and, similarly, various growth factors (i.e. angiotensin II. endothelins, transforming growth factor beta, fibroblast growth factors), are able to modulate the expression of several protooncogenes in the cells of the myocardium, and these events are linked to the development of cardiac hypertrophy. Major goals of future research will include the detection of the molecular mechanisms enabling the cardiomyocyte, a terminally differentiated muscle cell, to respond to a mitogenic stimulus with hypertrophic rather than hyperplastic growth, as well as the identification of drugs able to block the evolution of hypertrophy to heart failure.
Preliminary Results from NASA/GSFC Ka-Band High Rate Demonstration for Near-Earth Communications (2004)

In early 2000, the National Aeronautics and Space Administration (NASA) commenced the Ka-Band Transition Project (KaTP) as another step towards satisfying wideband communication requirements of the space research and earth exploration-satellite services. The KaTP team upgraded the ground segment portion of NASA's Space Network (SN) in order to enable high data rate space science and earth science services communications. The SN ground segment is located at the White Sands Complex (WSC) in New Mexico. NASA conducted the SN ground segment upgrades in conjunction with space segment upgrades implemented via the Tracking and Data Relay Satellite (TDRS)-HIJ project. The three new geostationary data relay satellites developed under the TDRS-HIJ project support the use of the inter-satellite service (ISS) allocation in the 25.25-27.5 GHz band (the 26 GHz band) to receive high speed data from low earth-orbiting customer spacecraft. The TDRS H spacecraft (designated TDRS-8) is currently operational at a 171 degrees west longitude. TDRS I and J spacecraft on-orbit testing has been completed. These spacecraft support 650 MHz-wide Ka-band telemetry links that are referred to as return links. The 650 MHz-wide Ka-band telemetry links have the capability to support data rates up to at least 1.2 Gbps. Therefore, the TDRS-HIJ spacecraft will significantly enhance the existing data rate elements of the NASA Space Network that operate at S-band and Ku-band.
Effect of Heat Stress and L-Ascorbic Acid-2-Phosphate Magnesium on Plasma and Liver Thiobarbituric Acid Reactive Substances Concentrations, and on Liver Protein Carbonyl Concentration in Chicks. (1997)

暑熱ストレスおよびL-アスコルビン酸-2-リン酸マグネシウム(APM)の飼料添加が7日齢のニワトリヒナに及ぼす影響について調査した。40°Cに3日間暴露したヒナの血漿および肝臓のチオバルビッール酸反応物(TBARS)濃度は対照区(30°C)のヒナに比較して有意に増加した。また,高温暴露ヒナの肝臓のタンパク質カルボニル量も増加する傾向が示された。APMの飼料添加により,高温暴露による肝臓TBARS濃度の増加は有意に減少し,血漿のTBARS濃度と肝臓のタンパク質カルボニル量は減少する傾向が示された。以上の結果より,高温暴露によりニワトリヒナに酸化ストレスが生じること,およびAPMの投与が高温暴露時に生じる酸化ストレスの緩和にある程度有効であることが示唆された。
Comparison of clinicopathological and genomic profiles in anal squamous cell carcinoma between Japanese and Caucasian cohorts (2023)

Anal squamous cell carcinoma (ASCC) is a rare tumor of the gastrointestinal tract. We aimed to compare the genetic backgrounds and their effect on clinical outcomes between Japanese and Caucasian patients with ASCC. Forty-one patients diagnosed with ASCC at the National Cancer Center Hospital were enrolled and evaluated for clinicopathological features, human papillomavirus (HPV) infection, HPV genotypes, p16 expression, PD-L1, and association of p16 status with the efficacy of concurrent chemoradiotherapy (CCRT). Target sequencing for hotspot mutations in 50 cancer-related genes was performed using genomic DNA from 30 available samples. Of 41 patients, 34 were HPV-positive (among them, HPV 16 was predominant; 73.2%); 38 patients were p16-positive (92.7%); and 39 patients received CCRT, of whom 36 were p16-positive and three p16-negative. p16-positive patients showed better complete response than p16-negative patients. Among 28 samples, 15 showed mutations in PIK3CA, FBXW7, ABL1, TP53, and PTEN; no difference in mutation profiles between the Japanese and Caucasian cohorts was observed. Actionable mutations were detected in both Japanese and Caucasian patients with ASCC. Genetic backgrounds, such as the HPV 16 genotype and PIK3CA mutations, were common regardless of ethnicity. p16 status may be a prognostic biomarker for CCRT in Japanese patients with ASCC.
Imaging of hemoglobin oxygen saturation using confocal photoacoustic system with three optical wavelengths (2008)

In this study, a confocal photoacoustic system with double-ring senor was used for imaging the map of hemoglobin oxygen saturation (SO<sub>2</sub>). This confocal photoacoustic system use focused optics for exploding photoacoustic signal, and the optical focus overlap with the focus of piezoelectric double-ring sensor. It has higher spatial resolution because the resolution is limited by the smaller optical focus rather than the ultrasonic focus of transducer. As near-infrared spectroscopy (NIRS), photoacoustic can distinguish oxygenated main blood chromophores such as hemoglobin (HbO<sub>2</sub>) and deoxygenated hemoglobin (Hb), by the optical absorption at multiple optical wavelengths. Three wavelengths pulse lasers (760nm, 805nm and 850nm) were employed to excitated photoacoustic signals, and acquire photoacoustic images of the vasculature in our experiment. In phantom samples test, two kinds of ink is employed to mimic HbO<sub>2</sub> and Hb, respectively. The PA images of two stimulant vessels showed that the calculated maps of saturation of mixed ink agree well with the preset value of sample. The <i>in vivo</i> experiment demonstrates an imaging of map of SO<sub>2</sub> in vessels at back of mouse. These demonstrated that this confocal photoacoustic system is potentially to noninvasive, high resolution image the distribution of SO<sub>2</sub> in tissues.
Mechanically Flexible and High-Performance CMOS Logic Circuits (2015)

Low-power flexible logic circuits are key components required by the next generation of flexible electronic devices. For stable device operation, such components require a high degree of mechanical flexibility and reliability. Here, the mechanical properties of low-power flexible complementary metal-oxide-semiconductor (CMOS) logic circuits including inverter, NAND, and NOR are investigated. To fabricate CMOS circuits on flexible polyimide substrates, carbon nanotube (CNT) network films are used for p-type transistors, whereas amorphous InGaZnO films are used for the n-type transistors. The power consumption and voltage gain of CMOS inverters are <500 pW/mm at Vin = 0 V (<7.5 nW/mm at Vin = 5 V) and >45, respectively. Importantly, bending of the substrate is not found to cause significant changes in the device characteristics. This is also observed to be the case for more complex flexible NAND and NOR logic circuits for bending states with a curvature radius of 2.6 mm. The mechanical stability of these CMOS logic circuits makes them ideal candidates for use in flexible integrated devices.
X-ray absorption and magnetic circular dichroism characterization of a novel ferromagnetic MnNx phase in Mn/Si3N4 multilayers (2008)

Ferromagnetism above room temperature has been observed in Mn/Si3N4 multilayered films for the first time. Characterization of the structural and electronic properties was performed to study the ferromagnetic behavior of this system. X-ray absorption spectroscopy at the Mn K and L edges, as well as x-ray magnetic circular dichroism, evidences the presence of divalent Mn in the films. X-ray absorption near edge structure measurements, which are compared to calculations, confirms the presence of a slightly distorted Mn3N2 phase that is proposed to be the origin of the ferromagnetism in this system.
PRED mafa (2011)

PREDmafa is a computational system for prediction of peptide binding to three transcriptionally abundant major histocompatibility complex (MHC) class I alleles of Mauritian cynomolgus macaque, an important animal model for the study of human disease. The prediction system utilizes quantitative matrices, which were validated using experimentally determined binders and supported by in vivo studies. We developed 8-mer and 9-mer prediction matrices for Mafa-A1*063:02, 9-mer, 10-mer, and 11-mer prediction matrices for Mafa-B*011:01, and a 9-mer prediction matrix for Mafa-B*075:01. To our knowledge, PREDmafa is the first online computational system for predicting peptides that bind Mafa molecules. It is available at http://cvc.dfci.harvard.edu/mafa/.
Biomass-Derived Thermally Annealed Interconnected Sulfur-Doped Graphene as a Shield against Electromagnetic Interference (2016)

Electrically conductive thin carbon materials have attracted remarkable interest as a shielding material to mitigate the electromagnetic interference (EMI) produced by many telecommunication devices. Herein, we developed a sulfur-doped reduced graphene oxide (SrGO) with high electrical conductivity through using a novel biomass, mushroom-based sulfur compound (lenthionine) via a two-step thermal treatment. The resultant SrGO product exhibited excellent electrical conductivity of 311 S cm(-1), which is 52% larger than 205 S cm(-1) for undoped rGO. SrGO also exhibited an excellent EMI shielding effectiveness of 38.6 dB, which is 61% larger than 24.4 dB measured for undoped rGO. Analytical examinations indicate that a sulfur content of 1.95 atom % acts as n-type dopant, increasing electrical conductivity and, therefore, EMI shielding of doped graphene.
Supplemental Material from Dual Inhibition of EGFR and c-Src by Cetuximab and Dasatinib Combined with FOLFOX Chemotherapy in Patients with Metastatic Colorectal Cancer (2023)

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Reflection-mode time-reversed ultrasonically encoded optical focusing into turbid media (2011)

Time-reversed ultrasonically encoded (TRUE) optical focusing was recently proposed to deliver light dynamically to a tight region inside a scattering medium. In this letter, we report the first development of a reflection-mode TRUE optical focusing system. A high numerical aperture light guide is used to transmit the diffusely reflected light from a turbid medium to a phase-conjugate mirror (PCM), which is sensitive only to the ultrasound-tagged light. From the PCM, a phase conjugated wavefront of the tagged light is generated and conveyed by the same light guide back to the turbid medium, subsequently converging to the ultrasonic focal zone. We present experimental results from this system, which has the ability to focus light in a highly scattering medium with a round-trip optical penetration thickness (extinction coefficient multiplied by round-trip depth) as large as 160.
Movement Patterns of Electric Cargo Bike Commuters – First Insights from Field Experiments and Trajectory Analyses (2021)

Abstract. In addition to and parallel to the SERVUS project, the requirements for a new, agile, urban cargo bicycle with electric drive are identified through a targeted, scientific application potential analysis in the project "E-Cargo Bike - Accompanying Research" described here. These findings are then implemented in the SERVUS project in an agile development and production process. Several prototypes are built in the process. The new e-cargo bicycles should be able to be used both privately and commercially. They will be presented to users for the first time at events (IAA 2021) and rated by them. In addition, the longer-term allocation of the bikes to selected users enables a cross-comparison with existing e-cargo bicycle models. Finally, the substitution potential of journeys in motorized individual transport is estimated and projected using the example of Munich. A key for gathering further information on the abilities of specific electric cargo bike types is tracking experiments with various sensor setups of which the first attempts are presented in this research. Additionally, and by enabling a certain spatial accuracy of gathered GNSS data, we are able to match selected maneuvers of these vehicle types to selected types of the Munich transportation infrastructure. Besides trajectory shapes of maneuvers, we are able to incorporate travel time and delay variations depending on investigation areas and times of the day at selected urban locations for every inspected maneuver (at for examples differing intersection geometries with and without traffic light signals). Another aspect is the presence of bicycle infrastructure and its relation to the option of using mixed traffic modes.
Synthesis and Characterization of Microcellular Injection Molded Polyolefin/Polycaprolactone Composites (2021)

This study investigated the effect of polycaprolactone (PCL) loading (0.5, 1, and 3 wt%) on the morphology, tensile strength, and thermal properties of microcellular injection molded PP/PCL and PPgMA/PCL composites. We used the filler, PCL, that is micro-material in size. Results showed that 0.5 wt% loading of PCL on foamed PP has the largest tensile strength. However, tensile strength was almost similar to that of PPgMA composites. Tensile strength depends on the filler dispersion in the matrix and cell size present on the foamed composites. Good dispersion resulted in good tensile strength. The elongation decreased on PP but increased on PPgMA composites. The highest degradation temperature for PP/PCL and PPgMA/PCL was noted for 3.0 wt% PCL loading and neat PPgMA respectively. Cell size decreased and cell density increased with the addition of PCL into the PP and PPgMA matrix.
Pediatric autoimmune neuropsychiatric disorders associated with streptococci (PANDAS): update (2009)

Despite continued research in the field, the relationship between GAS and specific neuropsychiatric disorders (PANDAS) remains elusive. It is possible that GAS infection may be but one of the many stressors that can exacerbate tic/Tourette's or OCD in a subset of such patients.
Measuring Blood Glucose Concentrations in Photometric Glucometers Requiring Very Small Sample Volumes (2016)

Glucometers present an important self-monitoring tool for diabetes patients and, therefore, must exhibit high accuracy as well as good usability features. Based on an invasive photometric measurement principle that drastically reduces the volume of the blood sample needed from the patient, we present a framework that is capable of dealing with small blood samples, while maintaining the required accuracy. The framework consists of two major parts: 1) image segmentation; and 2) convergence detection. Step 1 is based on iterative mode-seeking methods to estimate the intensity value of the region of interest. We present several variations of these methods and give theoretical proofs of their convergence. Our approach is able to deal with changes in the number and position of clusters without any prior knowledge. Furthermore, we propose a method based on sparse approximation to decrease the computational load, while maintaining accuracy. Step 2 is achieved by employing temporal tracking and prediction, herewith decreasing the measurement time, and, thus, improving usability. Our framework is tested on several real datasets with different characteristics. We show that we are able to estimate the underlying glucose concentration from much smaller blood samples than is currently state of the art with sufficient accuracy according to the most recent ISO standards and reduce measurement time significantly compared to state-of-the-art methods.
National early warning score to predict intensive care unit transfer and mortality in COVID‐19 in a French cohort (2021)

In hospitalised COVID-19 patients, NEWS was an independent predictor of ICU transfer and in-hospital death. In daily practice, NEWS ≥ 6 at admission may help to identify patients who are at risk to deteriorate.
Manipulating excited state hyperfine level populations in an atomic laser through electronic spin polarization: controlling upper laser level degeneracy and small signal gain (2017)

Anisotropic coherent radiation has been generated from an isotropic medium, in the absence of an external magnetic field, by the spin polarization of an atomic excited state. Lasing on specific hyperfine lines of the 6p<sup>2</sup>P<sub>32</sub>→6s<sup>2</sup>S<sub>12</sub> (D<sub>2</sub>) transition of Cs at 852.1 nm has been realized by photoexciting Cs-rare gas thermal collision pairs with a circularly-polarized (σ<sup>+</sup>) optical field. Subsequent dissociation of the transient Cs-rare gas B<sup>2</sup>Σ12+ diatomic molecule selectively populates the F = 4, 5 hyperfine levels of the Cs 6p<sup>2</sup>P<sub>32</sub> state. Not only does electronic spin polarization of the upper laser level yield circularly-polarized coherent emission, but the effective degeneracy (g<sub>2</sub>) of the 6p<sup>2</sup>P<sub>32</sub> state is altered by the non-statistical hyperfine state population distribution, thereby permitting control of the laser small signal gain with an elliptically-polarized pump optical field. The D<sub>2</sub> laser efficiency and output power correlate directly with the molecular orbital structure of the Cs-rare gas B<sup>2</sup>Σ<sup>+</sup> state in the region of internuclear separation at which the diatomic complex is born.
ESTUDIO SOBRE LA MOTIVACIÓN Y LA PRODUCCION DE SERVICIOS DEL PERSONAL DE SALUD DE LA REGION DE SALUD DE TACNA - 2012 (2019)

Introducción: El presente trabajo se realizó en la Región de Salud de Tacna, y se estudió al personal asistencial y Administrativo, en los aspectos de motivación en relación con la producción, a fin de determinar el impacto que tienen los niveles de motivación, satisfacción y jerarquía en la producción de servicio. Tipo de estudio descriptivo, transversal. Se obtuvo una muestra de 152 personas, aleatoria estratificada. Material y Métodos: La obtención de datos se efectuó a través de encuesta de motivación con factores específicos de la motivación, satisfacción posición o jerarquía, se evaluó las respuestas. Resultados: Los resultados se muestran en tablas encontrándose un mediano porcentaje de motivación en relación con el suelo recibido (88.59%) y los ascensos (77.84%), por otro lado, la evaluación del desempeño fue buena en forma global por cada grupo ocupacional. Conclusiones: Se comenta que para este caso las correlaciones entre la motivación y la producción son consistentemente en un rango medio. Se recomienda que los datos obtenidos en las encuestas sirvan para centrarse en estrategias que aminoren la no motivación y de que puedan mejorar la satisfacción. Aun cuando este estudio no apoya la tesis de que la motivación estimula la producción, se debe procurar que los trabajadores estén motivados a fin de lograr una organización más poderosa y eficiente.
Novel periodically loaded multilayer resonators (2002)

Abstract In this paper novel 3D periodic multilayer structures are investigated in MIC technology, and a periodically loaded multilayer waveguide resonant structure is proposed. This is a very compact structure and still maintains simple fabrication process. The resonator is designed at 10 and 28 GHz. The simulated results of this resonator, which is obtained from commercial FEM software package HFSS, are confirmed by experimental results. The experiments are based on the same resonator structure, only at 10 GHz. By modifying the conventional waveguide resonator, with the proposed structure, a minimum 30% shorter resonator can be achieved, which is very important in filter applications. © 2002 Wiley Periodicals, Inc. Microwave Opt Technol Lett 35: 374–375, 2002; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.10611
Endogenous Vasopressin Modulates the Cardiovascular Responses to Exercise (1999)

The role of brain-stem vasopressinergic projections in the genesis of reflex bradycardia and in the modulation of heart rate control during exercise is discussed on the basis of both changes in endogenous peptide content and heart rate changes observed during exercise. Dynamic running caused an increase in vasopressin content specifically in dorsal and ventral brain-stem areas. Rats pretreated with vasopressin or the V1 receptor antagonist into the nucleus tractus solitarii (NTS) showed a significant potentiation or a marked blunting of the exercise tachycardia, respectively, without any change in the blood pressure response. It is proposed that long-descending vasopressinergic pathways from the hypothalamus to the NTS serves as one link between the two main neural controllers of the circulation, that is, the central command and feedback control mechanisms driven by the peripheral receptors signals. Therefore vasopressinergic input contributes to the adjustment of heart rate response (and cardiac output) to the circulatory demand during exercise.
A REVIEW ON PHARMACEUTICAL CONSIDERATION OF OCIMUM SANCTUM (2018)

A deeper study revealed that O. sanctum has been attributed with actions that can increase pitta and body heat. It is mentioned to be a microbicidal agent. Because of its pungent taste and sharp and dry properties, it can increase pitta (one of the three doshas representing heat, transformation, digestion and metabolism) and should not be used in high doses or for a prolonged period in individuals with predominance of pitta or in diseases caused by derangement of pitta and rakta (blood), pungent substances with sharp and dry properties and hot potency are not generally considered to be good for fertility and should be used with care as O. sanctum has pungent taste. In the classical formulations the quantity of O. sanctum to be consumed per day varied from 0.74 mg to 86.14 mg. The plant Tulsi or Holy Basil (Botanical name Ocimum sanctum) belongs to family Lamiaceae. It is a tropical plant which grows as weed and also cultivated. Tulsi is worshipped by Hindus and is an important symbol of Hindu religion. It is a very common sight to find Tulsi Vrindavan (A special structure where Tulsi is grown) in houses of Hindus.
Memento mori: dynamic allocation-site-based optimizations (2015)

Languages that lack static typing are ubiquitous in the world of mobile and web applications. The rapid rise of larger applications like interactive web GUIs, games, and cryptography presents a new range of implementation challenges for modern virtual machines to close the performance gap between typed and untyped languages. While all languages can benefit from efficient automatic memory management, languages like JavaScript present extra thrill with innocent-looking but difficult features like dynamically-sized arrays, deletable properties, and prototypes. Optimizing such languages requires complex dynamic techniques with more radical object layout strategies such as dynamically evolving representations for arrays. This paper presents a general approach for gathering temporal allocation site feedback that tackles both the general problem of object lifetime estimation and improves optimization of these problematic language features. We introduce a new implementation technique where allocation mementos processed by the garbage collector and runtime system efficiently tie objects back to allocation sites in the program and dynamically estimate object lifetime, representation, and size to inform three optimizations: pretenuring, pretransitioning, and presizing. Unlike previous work on pretenuring, our system utilizes allocation mementos to achieve fully dynamic allocation-site-based pretenuring in a production system. We implement all of our techniques in V8, a high performance virtual machine for JavaScript, and demonstrate solid performance improvements across a range of benchmarks.