gebhart/patrepeval huggingface dataset:
Outcome of Resuscitative Thoracotomy and Descending Aortic Occlusion Performed in the Operating Room (1984)

Objectives of temporary descending thoracic aortic cross-clamping for exsanguinating abdominal hemorrhage are to redistribute intravascular volume to the myocardium and brain, and to limit further blood loss. This report describes our experience with left thoracotomy and descending aortic occlusion (T/AO) performed in the operating room (OR) for massive hemoperitoneum. During a 5-year period, 39 (5%) of 791 patients undergoing laparotomy for acute injury required T/AO in the OR. According to protocol, T/AO was undertaken before celiotomy if systolic blood pressure (SBP) remained less than 80 mm Hg despite full resuscitation (23 patients), and after celiotomy if SBP fell to less than 60 mm Hg with upper abdominal hemorrhage (16 patients). Mechanism of injury was gunshot wound in 21, stab injury in eight, and blunt trauma in ten. Twelve patients (31%) survived to leave the hospital. Seven of these individuals sustained hepatosplenic injuries, three had major vascular trauma, and the remaining two had combined injuries. Average SBP increased from 51 to 126 mm Hg following T/AO in the preceliotomy group, and from 48 to 131 mm Hg in post-celiotomy patients. The aorta was cross-clamped an average of 43 minutes in the preceliotomy patients, and 19 minutes in the post-celiotomy group. Six survivors (50%) developed major abdominal complications (rebleeding, fistulae, abscess, and pancreatitis). Only two patients, however, had pulmonary problems associated with T/AO; and both were minor (atelectasis and recurrent pneumothorax). In our experience, T/AO in the OR is successful in salvaging nearly one third of patients with life-threatening abdominal hemorrhage. The procedure can be performed rapidly, safely, and with minimal late sequelae.
Control of mitotic exit and cytokinesis by the APC/C (2008)

Inactivation of key substrates by ubiquitin-mediated proteolysis controls the passage of cells through mitosis. The APC/C (anaphase-promoting complex/cyclosome) targets a large number of substrates for proteolysis during the final steps of mitosis and cytokinesis, but the significance of these targeting events, particularly in mammalian cells, is largely unknown. In this review, I summarize what is known about how the APC/C selects its targets during mitotic exit and review the evidence that substrate targeting after anaphase onset may be required for the correct execution of events at this time in the cell cycle.
Eye Movement Sequences during Simple versus Complex Information Processing of Scenes in Autism Spectrum Disorder (2011)

Minshew and Goldstein (1998) postulated that autism spectrum disorder (ASD) is a disorder of complex information processing. The current study was designed to investigate this hypothesis. Participants with and without ASD completed two scene perception tasks: a simple "spot the difference" task, where they had to say which one of a pair of pictures had a detail missing, and a complex "which one's weird" task, where they had to decide which one of a pair of pictures looks "weird". Participants with ASD did not differ from TD participants in their ability to accurately identify the target picture in both tasks. However, analysis of the eye movement sequences showed that participants with ASD viewed scenes differently from normal controls exclusively for the complex task. This difference in eye movement patterns, and the method used to examine different patterns, adds to the knowledge base regarding eye movements and ASD. Our results are in accordance with Minshew and Goldstein's theory that complex, but not simple, information processing is impaired in ASD.
Birth of first foals through embryo transfer after artificial insemination using frozen semen in Japan (2020)

Until now, there have been no reports of foals born through embryo transfer after artificial insemination using frozen semen in Japan. The aims of this study were to develop a riding crossbred horse and evaluate the prospects of embryo transfer technology in multiplying horse population. In both donor and recipient mares, luteolysis was induced by the administration of 0.1 mg Cloprostenol to synchronize the onset of estrus, and ovulation was induced by administering 2000 IU human chorionic gonadotropin (hCG) or 0.75 mg Deslorelin. Frozen semen from an Irish Connemara pony stallion was used to breed a Hokkaido native pony mare by deep-horn artificial insemination (dose, 400 × 10<sup>6</sup> sperm). A non-surgical technique was used to collect embryos from the donor mare at day 7 post-ovulation and transfer them transcervically into the uterus of recipient mares (n = 4) immediately after collection. Weekly blood samples were collected from the recipients throughout pregnancy. A total of four embryos were recovered from seven collection attempts (57% recovery) from a donor mare in a single breeding season. Three of the four transferred embryos maintained successful pregnancy and delivered a healthy live foal (75% birth). A normal progesterone profile was observed throughout gestation in recipient mares. In conclusion, for the first time, to the best of our knowledge, this study describes the birth of foals through non-surgical transcervical embryo transfer in Japan after artificial insemination using frozen semen. We expect that this new crossbreed (Connemara pony × Hokkaido native pony) will be a good riding breed.
Development of Fibroblast Activation Protein–Targeted Radiotracers with Improved Tumor Retention (2019)

Cancer-associated fibroblasts constitute a vital subpopulation of the tumor stroma and are present in more than 90% of epithelial carcinomas. The overexpression of the serine protease fibroblast activation protein (FAP) allows a selective targeting of a variety of tumors by inhibitor-based radiopharmaceuticals (FAPIs). Of these compounds, FAPI-04 has been recently introduced as a theranostic radiotracer and demonstrated high uptake into different FAP-positive tumors in cancer patients. To enable the delivery of higher doses, thereby improving the outcome of a therapeutic application, several FAPI variants were designed to further increase tumor uptake and retention of these tracers. <b>Methods:</b> Novel quinoline-based radiotracers were synthesized by organic chemistry and evaluated in radioligand binding assays using FAP-expressing HT-1080 cells. Depending on their in vitro performance, small-animal PET imaging and biodistribution studies were performed on HT-1080-FAP tumor-bearing mice. The most promising compounds were used for clinical PET imaging in 8 cancer patients. <b>Results:</b> Compared with FAPI-04, 11 of 15 FAPI derivatives showed improved FAP binding in vitro. Of these, 7 compounds demonstrated increased tumor uptake in tumor-bearing mice. Moreover, tumor-to-normal-organ ratios were improved for most of the compounds, resulting in images with higher contrast. Notably two of the radiotracers, FAPI-21 and -46, displayed substantially improved ratios of tumor to blood, liver, muscle, and intestinal uptake. A first diagnostic application in cancer patients revealed high intratumoral uptake of both radiotracers already 10 min after administration but a higher uptake in oral mucosa, salivary glands, and thyroid for FAPI-21. <b>Conclusion:</b> Chemical modification of the FAPI framework enabled enhanced FAP binding and improved pharmacokinetics in most of the derivatives, resulting in high-contrast images. Moreover, higher doses of radioactivity can be delivered while minimizing damage to healthy tissue, which may improve therapeutic outcome.
Principales caractéristiques des gènes de résistance aux maladies chez les plantes et potentialités d'utilisation en sélection (1997)

La majorité des gènes de résistance clonés appartiennent à une grande famille de gènes codant pour des protéines présentant des motifs répétés riches en leucine. Les mêmes familles de gènes ont été identifiées chez des angiospermes très éloignées phylogenètiquement. Elles déterminent des spécificités de résistance contre des virus, des bactéries, des champignons voire des nématodes. Des mécanismes de duplication, mutation et recombinaison génétique semblent être les éléments majeurs de l'évolution du répertoire des gènes de résistance. Des expériences réalisées in vitro ont permis de démontrer que le produit d'un gène de résistance pouvait interagir directement avec le produit du gène d'avirulence de l'agent pathogène et que cette interaction constituait le facteur déclenchant de l'expression des gènes de défense de la plante conduisant à la résistance. De nombreuses applications à la sélection variétale apparaissent d'ores et déjà.
A high-performance 0.25- mu m CMOS technology. II. Technology (1992)

For Pt. I, see ibid., vol.39, no.4, pp.959-966 (1992). The key technology elements and their integration into a high-performance, selectively scaled, 0.25- mu m CMOS technology are presented. Dual poly gates are fabricated using a process where the poly and source/drain (S/D) are doped simultaneously. The critical issues related to the dual poly gate are addressed. A reduced operating voltage of 2.5 V is used which allows the application of shallow junctions with abrupt profiles (no LDD) to minimize the device series resistance as well as gate to source/drain overlap capacitance. The poly gate and the S/D sheet resistances are lowered, using a thin salicide (TiSi/sub 2/) process. The TiSi/sub 2/ thickness is reduced to maintain low leakage and low contact resistance for the shallow S/D junctions. The gate level with 0.4- mu m physical length is defined using optical lithography with a contrast enhanced layer (CEL) resist system.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Clinical guidelines for implementing relapse prevention therapy. (2002)

A guideline outlining this cognitive behaviour therapy approach. Focuses on identification of individual high-risk situations and the person's ability to cope with them without relapsing, as well as learning new coping skills and enhancing self-efficacy.
Abstract LB-169: Ovarian cancer cells selectively release exosomes containing tumor suppressor miRNAs to maintain SRC-mediated oncogenic activities (2016)

Abstract Exosomes have emerged as an important mediator of diverse biological functions including tumor cell progression, invasion, immune escape, and cell-to-cell communication, through the release of molecules such as mRNAs, microRNAs, and proteins. Ovarian cancer (OC) is one of the lethal cancers with extensive local invasion, metastasis, and poor diagnosis. Thus, finding novel targets for OC therapy are urgently needed. Here, we isolated 30-140 nm exosomes from the supernatant of one normal and six different OC cells. In addition, RNAs were isolated from cells and exosomes, and profiles of two miRNA fractions were obtained using affymetrix microarray analysis. By comparing signal intensities of microarray data and validation using RT-PCR analysis, we found that miR-940 was abundant in exosomes from SKOV3IP1, HeyA8, and HeyA8-MDR. Ectopic expression of miR-940 inhibited proliferation, colony formation, invasion, migration, induced G0/G1 cell cycle arrest, and apoptosis in OC. Overexpression of miR-940 also inhibited tumor cell growth in vivo. The target gene of miRNA-940 and the downstream pathway were further investigated using several target prediction algorithms. We identified specific targeting sites for miR-940 in the 3’-untranslated region (3’-UTR) of SRC. We then experimentally validated miR-940 as a direct regulator of SRC using cell transfection and luciferase assays, and showed that miR-940 inhibited SRC expression at mRNA and protein levels. Following this reduction, the activity of proteins downstream of SRC, such as FAK, paxillin and Akt were also reduced. Collectively, our results suggest that OC cells selectively secreted the tumor suppressive miR-940 into the extracellular environment via exosomes, to maintain their invasiveness and tumorigenic phenotype. Citation Format: Mohammed H. Rashed, Pinar Kanlikilicer, Cristian Rodriguez Aguayo, Nashwa N. Kabil, Martin Pichler, Recep Bayraktar, Emine Bayraktar, Cristina Ivan, Rahul Mitra, George A. Calin, Anil K. Sood, Mohamed F. Abd-Ellah, Gouda K. Helal, Gabriel Lopez Berestein. Ovarian cancer cells selectively release exosomes containing tumor suppressor miRNAs to maintain SRC-mediated oncogenic activities. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr LB-169.
CAN gateway for fast vehicle to vehicle (V2V) communication (2015)

Intelligent transport systems (ITS) use information and communication technologies to improve vehicle safety on roadways and effective traffic flow management. A vehicle communicates with other vehicles and/or infrastructures with wired/wireless communication technologies. In-vehicle networks are composed of numerous electronic control units (ECUs) according to the type of service in various domains (e.g. powertrain domain, body domain, and chassis domain). Vehicle to vehicle (V2V) messages related to vehicle safety should meet low-latency requirements. In addition, the information contained in V2V messages is associated with specific ECUs. For the interworking between the V2V communications and in-vehicle networks, we should consider a new method that responses necessary ECUs for specific V2V message. In this paper, we propose an effective controller area network (CAN) gateway method. This method uses CAN gateway searching for a network table based on the CAN frame for V2V message. Because of simple structure and method, the proposed method can be a good solution that controls the ECUs with ease. And it also can make V2V messages at high speed.
Efficient Quadtree Compression for Temporal Trajectory Filtering (2013)

Summary form only given. Spatial in loop filters are a well established tool to improve the compression performance of today's video codecs. Temporal denoising and deblocking filters have recently also received some attention, because of their ability to stabilize pictures and to reduce flickering artifacts. One such filter, the previously introduced Quad tree-based Temporal Trajectory Filter, can produce good results, provided that the associated quad tree is sufficiently detailed. In this paper a novel, generally applicable scheme to compress such quad tree information is presented. In addition, the performance of the filter within the current HEVC test model HM 8.0 is investigated.
Portable sensor to measure the mechanical compliance transfer function of a material (2006)

Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2006.
PRECISION AIDED INERTIAI,ON USING AND DI- (1990)

This paper describes a novel scheme for obtaining position update information for an inertial navigation system through the use of imagery from a synthetic aperture radar (SAR) sensor and an onboard digital map database. Update information is obtained through comparison of the locations of terrain features extracted from the SAR imagery with locations predicted using the digital map and current navigation estimates. The paper includes a detailed discussion of the overall system concept along with experimental and analytical results obtained to date. Analytical results include a preliminary error analysis which treats SAR image distortions introduced through navigation errors and the consequent effects on update accuracies. A description of the terrain feature extraction algorithms is presented along with experimental results.
Dislocation of the cuboid (1945)

Journal Article Dislocation of the cuboid Get access Alexander Mitchell Alexander Mitchell Search for other works by this author on: Oxford Academic Google Scholar British Journal of Surgery, Volume 32, Issue 128, April 1945, Page 534, https://doi.org/10.1002/bjs.18003212828 Published: 12 December 2005
Risks of Antibiotic Exposures Early in Life on the Developing Microbiome (2015)

During birth, a relatively sterile unborn child becomes a newborn coated with microbes on every surface. This collection of bacteria, archaea, viruses, and fungi found in and on the human body is called the microbiota. The collective genomes of the microbiota are considered to be the metagenome, and the totality of the microbiota, metagenome, and their interactions is the microbiome. The microbiota has many critical functions including protection from pathogens, development and maintenance of the immune system, and helping the host access nutrients in food. The gut microbiota has been of particular interest, as perturbations of this community have been linked to disease states including autoimmune disease and neurological disorders. Antibiotics have consistently been shown to change the gut microbiome in humans and animals. We briefly review the importance of the early-life gut microbiome and the risks of disturbing it with antibiotics.
Intratumoral doxycycline for skin metastases of human malignancies. (1987)

As soon as its inducibility of lethality via prompt deprivation of heavy metals and HDL-cholesterol was born out, an intratumoral administration of doxycycline, an anti-prokaryotic agent, was undertaken in 7 patients presenting with skin metastases from a variety of malignancies. Complete remission of these lesions was attained in 6. The histological observation of elongated areas of acellularity along with central vessels appeared to suggest doxycycline-mediated cellular disintegration, resulting in empty tumor cords. Specific tumor selectivity of the treatment can be sustained by the intra- and/or peri-tumoral confinement of the agent. The technique may constitute a novel mode of cancer cell elimination.
Successful Treatment of Gastrointestinal Mucormycosis in an Adult with Acute LeukemiA: Case Report and Literature Review (2017)

Mucormycosis has emerged as an important cause of invasive fungal infection in patients with hematologic malignancies. Gastrointestinal mucormycosis is an unusual presentation of this invasive fungal infection, and it causes considerable morbidity and mortality. Such outcomes are due in part to a nonspecific presentation that results in delays in diagnosis and treatment. Successful treatment of gastrointestinal mucormycosis involves surgical debridement and appropriate antifungal therapy.
Plasma wound treatment: From physics to animal models (2010)

Summary form only given. Non-thermal treatment of wounds has been often mentioned as one of the most promising applications of plasma in medicine. Possibility of reducing bacterial load with plasma treatment has been suggested by some experiments on fresh meat, cadavers and living mice. Initial clinical results with human patients have also been reported. Animal experiments have been carried out to test toxicity of some plasma treatments. Possibility of enhanced growth of cells following some plasma treatment has been suggested through in-vitro experiments.
Fabrication and testing of hemispherical MEMS wineglass resonators (2013)

This work focuses on understanding the behavior of 3D hemispherical shells operating in wineglass resonance mode through finite element modeling (FEM). Fabrication of the hemispherical shells was done using micromachining technique. The quality factor of the device was in excess of 10,000 when operated in 50mT vacuum. The shell showed better than 95% sphericity and had an rms surface roughness of ~5nm. The separation in the degenerate frequencies of 4-node wineglass resonance was 5 Hz at a resonant frequency of 22 kHz. Modeling of the device behavior relates the frequency mismatch to the asymmetry in the shell and quantifies it.
The Effects of Small Lot Manufacturing on AMHS Operation and Equipment Front-End Design ISSM Paper: FD-O-238 (2007)

This paper analyzes the effects of small lot manu- facturing (SLM) on equipment operation and fab perform- ance. It also discusses equipment front-end design challenges and describes options for carrier handling and AMHS opera- tion to maximize the productivity benefits of small lot manu- facturing. This paper focuses primarily on the material han- dling aspects of SLM and as such, does not discuss the influ- ences of equipment Setup or First Wafer Delay which have been covered in other related publications. I. INTRODUCTION AB performance cannot be measured with a single performance indicator, so a set of key performance indicators derived from the overall manufacturing objec- tives is normally used. These objectives have traditionally been categorized as: • quality (speed, yield), • cost (technology node, fab-throughput) and • delivery (cycle time). However, in recent years the semiconductor industry has seen a shift towards a more consumer-driven market, re- sulting in more fluctuations in product variety and demand, shorter product life cycles and rapidly declining ASP's. Traditional manufacturing methods are therefore being overhauled in order to meet these new challenges, and IC makers are being forced to improve their manufacturing agility to keep pace with these new market dynamics. De- livery performance and cycle time reduction are two key enablers that are fundamental to meeting these challenges, cf. (2). Small Lot Manufacturing (SLM) i.e. reducing the num- ber of wafers in a lot, is one approach to reduce cycle time (CT) and WIP in a semiconductor fab, cf. (1) and (5). The smaller lot size obviously reduces lot process time at single wafer tools, but it also enables a queue time reduction that has an even higher influence on CT and WIP. However, current equipment and material handling sys- tem designs are not conducive to SLM. In particular, SLM requires carrier delivery intervals and carrier exchange times to be reduced and both parameters have to match the AMHS performance characteristics to prevent productivity
Chemical and Thermal Stability of Potassium Nickel Hexacyanoferrate(II). (1997)

The chemical and thermal stability of a nonstoichiometric compound K2-xNix/2[NiFe(CN)6]·nH2O (KNiFC) were examined in connection with distribution behavior for Cs+. The face-centered cubic (FCC) structure of KNiFC was stable even in the presence of 8M HCl or 8M HNO3, and the samples treated with acids had high K d values for Cs+ above 104 cm3/g. This suggests high resistance of KNiFC to acids. For the KNiFC treated with HNO3, the lattice parameter (α) increased with increasing the concentration of HNO3 above 1M. The FCC structure decomposed with NaOH concentrations above 1M, probably due to the hydrolysis of constitutional elements. The thermal decomposition began above 250°C and several steps of weight loss, due to evolution of gases, were observed up to 1,000°C.
Efficacy of an individualized written home‐management plan in the control of moderate persistent asthma: A randomized, controlled trial (2005)

The addition of a written individualized home-management plan improves overall control in children with moderate persistent asthma.