gebhart/patrepeval huggingface dataset:
Racial Disparities in the Utilization and Outcomes of Structural Heart Disease Interventions in the United States (2019)

Background Data on race- and ethnicity-based disparities in the utilization and outcomes of structural heart disease interventions in the United States are scarce. Methods and Results We used the National Inpatient Sample (2011-2016) to examine racial and ethnic differences in the utilization, in-hospital outcomes, and cost of structural heart disease interventions among patients ≥65 years of age. A total of 106 119 weighted hospitalizations for transcatheter aortic valve replacement, transcatheter mitral valve repair, and left atrial appendage occlusion were included. The utilization rates (defined as the number of procedures performed per 100 000 US people >65 years of age) were higher in whites compared with blacks and Hispanics for transcatheter aortic valve replacement (43.1 versus 18.0 versus 21.1), transcatheter mitral valve repair (5.0 versus 3.2 versus 3.2), and left atrial appendage occlusion (6.6 versus 2.1 versus 3.5), respectively (P<0.001). Black and Hispanic patients had distinctive socioeconomic and clinical risk profiles compared with white patients. There were no significant differences in the adjusted in-hospital mortality or key complications between patients of white race, black race, and Hispanic ethnicity following transcatheter aortic valve replacement, transcatheter mitral valve repair, or left atrial appendage occlusion. No difference in cost was observed between white and black patients following any of the 3 procedures. However, Hispanic patients incurred modestly higher cost with transcatheter mitral valve repair and left atrial appendage occlusion compared with white patients. Conclusions Racial and ethnic disparities exist in the utilization of structural heart disease interventions in the United States. Nonetheless, adjusted in-hospital outcomes were comparable among white, black, and Hispanic patients. Further studies are needed to understand the reasons for these utilization disparities.
Supplementary Figure 2 from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of <i>ABCG2</i> and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells (2023)

&lt;p&gt;PDF file - 87K, Bar graph depicting total number of differentially expressed genes, as well as relative numbers induced or repressed under various treatment conditions&lt;/p&gt;
Inteligencia emocional y la variable género (2002)

La inteligencia emocional (IE) es un constructo relativamente reciente, acunado por Salovey y Mayer en el ano 1990, para referirse a la habilidad de manejar las emociones, de diferenciarlas y de utilizar esta informacion de forma adaptativa. Tradicionalmente se ha considerado que las mujeres se socializan priorizando su desarrollo emocional, y que son mas habiles en la comprension y manejo de las emociones. En este trabajo nos proponemos analizar la investigacion empirica desarrollada acerca de la IE en general, y en particular, los estudios que han incluido la variable genero en sus analisis, tratando de establecer la relacion entre la IE y el genero. Los resultados generales apuntan a que no existen suficientes investigaciones sobre este tema como para poder extraer conclusiones firmes acerca de la relacion del genero con la IE
Design Criteria and Modulation Strategies for Complete ZVS Operation of the Bidirectional Interleaved Boost Converter with Coupled Inductors (2019)

This paper investigates the behavior of the Bidirectional Interleaved Boost converter with Coupled Inductors, exploring all possible degrees of freedom. Such analysis allows to find the current values at the device switching instants for all possible operating points, thus highlighting the regions where ZVS is lost. At the same time, the modulation for the minimum RMS current in all devices can be found.A new design and modulation strategy has been proposed to achieve ZVS in the whole operating range. Experimental results taken on a 1.5 kW prototype, validated the theoretical analysis.
Bonding and mechanical properties of ultrathin diamond-like carbon films (2002)

Ultrathin 2-nm-thick carbon coatings are needed to increase the storage density in magnetic hard disks. We show how x-ray reflectivity, surface Brillouin scattering, resonant Raman scattering, and electron energy loss spectroscopy can measure consistently the structural and mechanical properties of these thin films. 2 nm films retain a Young’s modulus of 100 GPa.
<title>High-Q rf passives on organic substrates using a low-cost low-temperature laminate process</title> (2002)

This paper reports on a low-cost low-temperature (<EQ150 degree(s)C) laminate batch fabrication process for implementation of high-Q RF passive components (inductors and capacitors) in system-on-package (SOP) applications. Using this process, various designs of integrated inductors with Q-factors in the range of 50-180 for Bluetooth/IEEE 802.11b (2.4GHz0, GSM1800 (1.8GHz) and GSM900 (900MHz) communication standards have been implemented on an organic package substrate. For the first time, a maximum Q of 180 was measured for a 4.8nH inductor at 2.0 GHz on an organic substrate with a self-resonance frequency (SRF) of 5.5 GHz within an area of 9mm<sup>2</sup>. High-Q inductors and capacitors integrated on low-loss organic package substrates can find numerous RF and microwave SOP applications (such as VCO, IF/RF bandpass filters, LNA, etc., in which IC chips are flip-chip mounted on the package substrate. Integration of passives in organic substrates eliminates the excess cost of assembly, enables miniaturization by allowing for added functionality at the board level, and provides an attractive alternative to higher temperature processes such as ceramic and deposition technologies for high-Q passive implementation.
Impact of Track Structure Effects on Shielding and Dosimetry (1999)

Galactic cosmic rays (GCR) consisting of nuclei of all the known elements with kinetic energies extending from tens to millions of MeV pose a significant health hazard to future deep space operations. Even half of the radiation exposures expected in ISS will result from GCR components.The biological actions of these radiations are known to depend on the details of the energy deposition (not just linear energy transfer, LET, but the lateral dispersion of energy deposition about the particle track).
TechEdSat-N and ETC Series (2017)

This presentation address the issues and how to involve students in the process of develping, building and certifying flight hardware for ISS and development of Mars missions.
Structure Activity Relationship of Arylidene Pyrrolo and Pyrido [2,1-b] Quinazolones as Cytotoxic Agents: Synthesis, SAR Studies, Biological Evaluation and Docking Studies (2013)

Tubulin is the one of the most useful and strategic molecular targets for anticancer drugs. Agents that bind in Colchicine-binding site of tubulin include Phenstatin, Combretastatin A-4, Colchicine, Steganacin, Podophyllotoxin and certain other synthetic analogues of these compounds. Arylidene pyrollo and pyrido [2,1- b] quinazolones (isoindigatone and its synthetic analogues) have been earlier reported to be tubulin inhibitors evidenced by tubulin polymerization assay. The present study is an extension of the library of the isoindigatone and its synthetic analogues to generate the structure activity relationship. The study explores the role of the arylidene ring and also provides some intresting observations such as the placement of bicyclic ring such as naphylidene for potential activity. Some of the important interactions of KNH- 3 and KNH-11 with the amino acid residues of active site of Tubulin have also been observed by molecular modeling.
Chemische Synthese & funktionelle Analyse von immobilisierten Protein-Domänen (2017)

Protein-Arrays sind das Mittel der Wahl, um eine Vielzahl von Proteinen parallel zu untersuchen. Ziele dieser Untersuchungen sind meistens Proteininteraktionsnetzwerke zu entdecken oder besser verstehen zu können. Bisher wurden die benötigten Proteine fast ausschließlich mit biologischen Methoden gewonnen. Diese bieten allerdings keinen generellen Zugang zu posttranslational-modi-fizierten (PTM)-Proteinen. Somit war es bisher nicht möglich den Einfluss von PTMs auf Protein-Protein-Interaktionen (PPIs) im Arrayformat zu untersuchen. Die chemische Synthese kann dagegen Proteine mit ortsspezifischen PTMs liefern. Daher ist es verwunderlich, dass bislang noch keine Berichte über chemisch hergestellte PTM-Protein-Arrays existieren, besonders da PTMs meist entscheidend für proteomische Interaktionsnetzwerke sind. In der vorliegenden Arbeit wird eine Methodik beschrieben, die es ermöglicht PTM-modifizierte Protein-Domänen-Arrays auf der Oberfläche zu synthetisieren und zu analysieren. Mit der Methodik wurden 20 SH3-Domänen synthetisiert und 64 PPIs gemessen. Neben vier Hefe-SH3-Domänen wurden je acht humane (Phospho)SH3-Domänen der Abl- und Arg(Abl2)-Tyrosinkinase synthetisiert und funktionell untersucht. Es wurde gefunden, dass die Ligandenspezifität von Abl-SH3-Domänen durch Phosphorylierung feinreguliert wird. Je nach Phosphorylierungsmustern wurde die Affinität für spezifische Liganden erhöht oder erniedrigt. Der Ursprung dieser Phosphoregulierung wurde für die Abl-SH3-Domäne mit Hilfe der NMR-Spektroskopie und durch Zellexperimente versucht zu entschlüsseln und weiter validiert.
Supplementary Movie 1 from STAT3-Mediated Autophagy Dependence Identifies Subtypes of Breast Cancer Where Autophagy Inhibition Can Be Efficacious (2023)

&lt;p&gt;MOV file - 3141K, MCF7 cells were transduced with a Non-silencing shRNA and imaged for 48h.&lt;/p&gt;
Quantitative elemental imaging in eukaryotic algae (2023)

All organisms, fundamentally, are made from the same raw material, namely the elements of the periodic table. Biochemical diversity is achieved by how these elements are utilized, for what purpose, and in which physical location. Determining elemental distributions, especially those of trace elements that facilitate metabolism as cofactors in the active centers of essential enzymes, can determine the state of metabolism, the nutritional status, or the developmental stage of an organism. Photosynthetic eukaryotes, especially algae, are excellent subjects for quantitative analysis of elemental distribution. These microbes utilize unique metabolic pathways that require various trace nutrients at their core to enable their operation. Photosynthetic microbes also have important environmental roles as primary producers in habitats with limited nutrient supplies or toxin contaminations. Accordingly, photosynthetic eukaryotes are of great interest for biotechnological exploitation, carbon sequestration, and bioremediation, with many of the applications involving various trace elements and consequently affecting their quota and intracellular distribution. A number of diverse applications were developed for elemental imaging, allowing subcellular resolution, with X-ray fluorescence microscopy (XFM, XRF) being at the forefront, enabling quantitative descriptions of intact cells in a non-destructive method. This Tutorial Review summarizes the workflow of a quantitative, single-cell elemental distribution analysis of a eukaryotic alga using XFM.
Tangible user interfaces for children (2005)

Tangible user interfaces, which provide interactivity using real physical objects, hold enormous promise for children. Exploring and manipulating physical objects is a key component of young children's learning. The educational power of digital technology for children has typically been limited by the fact that users explore and manipulate abstract two-dimensional screen-based representations, and not real physical objects. Embedding interactivity into physical objects, therefore, allows the "best of both worlds" - supporting traditional exploratory play with physical objects that can be extended and enhanced by the interactive power of digital technology. Participants in this SIG are invited to share ideas regarding the design and development of tangible interfaces, and to bring demos or slides/videos showing work in this area. Participants will review as many examples as time allows, and discuss the issues surrounding design and development of such interfaces. A primary goal of this SIG is to foster the development of a community of researchers and practitioners who are focused on designing and developing tangible interfaces for children.
Novel online RF technique for detection of water trees in underground powered distribution cables (2011)

In this paper we investigate the use of RF signals to measure dielectric loss and the change of permittivity of an energized cable's insulation. One common degradation mechanism is growth of water trees in the presence of water. We present theoretical analysis of a novel on-line water tree detection technique based on using RF TEM wave propagation via test points on an elbow. Our method is based on injecting a high frequency RF signal into an energized cable at different points of the line voltage values and measure the nonlinearity of permittivity and dielectric loss.
Development of Nucleic‐Acid‐Based Electrochemical Biosensors for Clinical Applications (2022)

Nucleic acids are remarkable molecules. In addition to Watson-Crick base pairing, the different structural motifs of these molecules can bind non-nucleic acid targets or catalyze chemical reactions. Additionally, nucleic acids are easily modified with different molecules or functional groups. These properties make nucleic acids, particularly DNA, ideally suited for use in electrochemical biosensors, both as biorecognition elements and redox reporter probes. In this Minireview, we will review the historical evolution of nucleic acids as probes in electrochemical biosensors. We will then review the specific examples of nucleic-acid-based biosensors that have been evaluated for clinical use in the areas of infectious disease, cancer, or cardiovascular health.
Analysis of barium sulfate by atomic absorption (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAnalysis of barium sulfate by atomic absorptionJohn L. Bove, Martha Magyar, Benjamin Nathanson, Stanley Siebenberg, and Edward F. FerrandCite this: Environ. Sci. Technol. 1971, 5, 4, 358–359Publication Date (Print):April 1, 1971Publication History Published online1 May 2002Published inissue 1 April 1971https://pubs.acs.org/doi/10.1021/es60051a007https://doi.org/10.1021/es60051a007research-articleACS PublicationsRequest reuse permissionsArticle Views174Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Preparation of oligo-dsDNA parts v1 (2020)

Modular cloning standards based on Golden Gate DNA assembly allow construction of complex DNA constructs over several rounds of assembly.Each Modular cloning toolkit uses different vectors that can be compatible or not with other systems. And the vectors in each toolkit have advantages and disadavantges based on what their intended use. JUMP vectors combine the robusness of modular cloning standards with much more flexibility. They have a flexible backbone base on the Standard European Vector Architecture (SEVA) and researchers can add additional features with additional secondary cloning sites that allow orthogonal assemblies.
Integriertes Design und Fertigung optischer Bauelemente (2013)

Abstract Komplexe, diffraktiv funktionalisierte freiformoptische Bauelemente bieten neue Möglichkeiten für die Realisierung leistungsfähiger, kompakter und robuster optischer Systeme. In diesem Beitrag werden geeignete integrierte Designund Fertigungsstrategien vorgestellt. Am Beispiel eines hybriden reflektiven Strahlformers, der ablenkende, strahlformende und strahlteilende Funktionalitäten in sich vereint, wird die Leistungsfähigkeit des Ansatzes theoretisch und experimentell untersucht.
An inference technique for integrating knowledge from disparate sources (1981)

This paper introduces a formal method for integrating knowledge derived from a variety of sources for use in perceptual reasoning. The formalism is based on the proposltlonal calculus, a derivative of Shafer's mathematical theory of evidence [4]. It is more general than either a Boolean or Bayeslan approach, providing for Boolean and Bayeslan inferencing when the appropriate information is available. In this formalism, the likelihood of a proposition A is represented as a subinterval, [s(A), p(A)], of the unit interval, [0, 1]. The evidential support for proposition A is represented by s(A), while p(A) represents its degree of plausibility; p(A) can also be interpreted as the degree to which one fails to doubt A, p(A) being equal to one minus the evidential support for A. This paper describes how evidential information, furnished by a knowledge source in the form of a probability mass distribution, can be converted to this interval representation; how, through a set of inference rules for computing intervals of dependent propositions, this Information can be extrapolated from those propositions it directly bears upon, to those it indirectly bears upon; and how multiple bodies of evidential Information can be pooled. A sample application of this approach, modeling the operation of a collection of sensors (a particular type of knowledge source), illustrates these techniques.
HW/SW codesign for embedded telecom systems (2002)

The aim of this paper is to define an approach, tailored for control-oriented applications, to manage system cospecification, high-level partitioning, hw/sw tradeoffs and cosynthesis. Our research effort focuses on fulfilling the goal of linking high-level specifications to efficient and cost-effective hw/sw implementations by investigating techniques such as synchronous cospecification styles, direct machine code generation as well as exploiting the capability of commercial VHDL synthesis tools.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Wnt signals from the neural tube block ectopic cardiogenesis (2001)

It has long been observed that repressive signals from the neural tube block cardiogenesis in vertebrates. Here we show that a signal from the neural tube that blocks cardiogenesis in the adjacent anterior paraxial mesoderm of stage 8-9 chick embryos can be mimicked by ectopic expression of either Wnt-3a or Wnt-1, both of which are expressed in the dorsal neural tube. Repression of cardiogenesis by the neural tube can be overcome by ectopic expression of a secreted Wnt antagonist. On the basis of both in vitro and in vivo results, we propose that Wnt signals from the neural tube normally act to block cardiogenesis in the adjacent anterior paraxial mesendoderm.
Asymmetric Total Synthesis of Pyranicin (2020)

The asymmetric total synthesis of pyranicin (1) is reported. The butenolide ring was constructed via an asymmetric alkylation/ring-closing metathesis strategy. The three stereocenters in the left-hand tetrahydropyran ring were installed by sequential chiral auxiliary-mediated aldol reactions. Closure of the tetrahydropyran and fusion of the alkyl backbone were affected via a sequential ring-closing metathesis cross-metathesis strategy.
Mitochondrial oxidative phosphorylation controls cancer cell's life and death decisions upon exposure to MAPK inhibitors (2016)

Although MAPK pathway inhibitors are becoming a promising anticancer strategy, they are insufficient to fully eliminate cancer cells and their long-term efficacy is strikingly limited in patients with BRAF-mutant melanomas. It is well established that BRAF inhibitors (BRAFi) hamper glucose uptake before the apparition of cell death. Here, we show that BRAFi induce an extensive restructuring of mitochondria including an increase in mitochondrial activity and biogenesis associated with mitochondrial network remodeling. Furthermore, we report a close interaction between ER and mitochondria in melanoma exposed to BRAFi. This physical connection facilitates mitochondrial Ca2+ uptake after its release from the ER. Interestingly, Mfn2 silencing disrupts the ER-mitochondria interface, intensifies ER stress and exacerbates ER stress-induced apoptosis in cells exposed to BRAFi in vitro and in vivo. This mitochondrial control of ER stress-mediated cell death is similar in both BRAF- and NRAS-mutant melanoma cells exposed to MEK inhibitors. This evidence reinforces the relevance in combining MAPK pathway inhibitors with mitochondriotropic drugs to improve targeted therapies.
Nanofiltration in Organic Solvents (2008)

This chapter contains sections titled: Organic Solvent Nanofiltration Membranes OSN Transport Mechanisms—Theoretical Background Applications of Organic Solvent Nanofiltration References
IL-12 Augments CD8+ T Cell Development for Contact Hypersensitivity Responses and Circumvents Anti-CD154 Antibody-Mediated Inhibition (2001)

During sensitization with dinitrofluorobenzene for contact hypersensitivity (CHS) responses, hapten-specific CD8(+) T cells develop into IFN-gamma-producing cells, and CD4(+) T cells develop into IL-4/IL-5-producing cells. Administration of IL-12 during sensitization skews CD4(+) T cell development to IFN-gamma-producing cells, resulting in exaggerated CHS responses. In the current report we tested the role of IL-12 on CD8(+) T cell development during sensitization and elicitation of CHS to dinitrofluorobenzene. Administration of IL-12 during hapten sensitization induced the expression of IL-12Rbeta2 on both CD4(+) and CD8(+) T cells, augmented IFN-gamma production by these T cell populations, and increased the magnitude and duration of the CHS response to hapten challenge. CHS responses were virtually identical in wild-type and IL-12 p40(-/-) mice. Since engagement of CD40 on APC may stimulate IL-12 production, we also tested the role of CD40-CD154 interactions on the development of IFN-gamma-producing CD4(+) and CD8(+) T cells following hapten sensitization. Development of IFN-gamma-producing CD4(+) T cells during hapten sensitization was absent in wild-type mice treated with anti-CD154 mAb or in CD154(-/-) mice. In contrast, the absence of CD40-CD154 signaling had little or no impact on the development of IFN-gamma-producing CD8(+) T cells. These results demonstrate that the development of hapten-specific Th1 effector CD4(+) T cells in CHS requires both CD40-CD154 interactions and IL-12, whereas the development of IFN-gamma-producing effector CD8(+) T cells can occur independently of these pathways.
Towards a simplified infinite horizon model predictive controller (2004)

This paper investigates the constrained infinite horizon linear quadratic regulator (ClHLQR). In particular it is shown that the terminal set inclusion condition that is associated with this control law introduces limitations into the control system. By relaxing this condition it is demonstrated that the resulting controller will in many cases remain equivalent to CIHLQR. It is further shown that ClHLQR with a relaxed terminal set inclusion condition offers significant benefits, in terms of computational expense and performance when compared with standard finite horizon model predictive control (MPC) approaches.