gebhart/patrepeval huggingface dataset:
Parenteral nutrition in the surgical patient (1987)

Journal Article Parenteral nutrition in the surgical patient Get access L K R Shanbhogue, L K R Shanbhogue Nutritional Support Service, New England Deaconess Hospital, Harvard Medical School, Boston, Massachusetts, USA Present address: Department of Surgery, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, UK Search for other works by this author on: Oxford Academic Google Scholar W J Chwals, W J Chwals Nutritional Support Service, New England Deaconess Hospital, Harvard Medical School, Boston, Massachusetts, USA Search for other works by this author on: Oxford Academic Google Scholar M Weintraub, M Weintraub Nutritional Support Service, New England Deaconess Hospital, Harvard Medical School, Boston, Massachusetts, USA Search for other works by this author on: Oxford Academic Google Scholar G L Blackburn, G L Blackburn Nutritional Support Service, New England Deaconess Hospital, Harvard Medical School, Boston, Massachusetts, USA Correspondence to: Dr G. L. Blackburn, Cancer Research Institute, 194 Pilgrim Road, Boston, MA 02215, USA Search for other works by this author on: Oxford Academic Google Scholar B R Bistrian B R Bistrian Nutritional Support Service, New England Deaconess Hospital, Harvard Medical School, Boston, Massachusetts, USA Search for other works by this author on: Oxford Academic Google Scholar British Journal of Surgery, Volume 74, Issue 3, March 1987, Pages 172–180, https://doi.org/10.1002/bjs.1800740307 Published: 08 December 2005 Article history Accepted: 16 August 1986 Published: 08 December 2005
405 Volumetric Quantification of Subarachnoid Hemorrhage Independently Predicts Hydrocephalus and Seizures (2022)

INTRODUCTION: Hydrocephalus and seizures greatly impact outcomes of patients with aneurysmal subarachnoid hemorrhage (aSAH); however, reliable tools to predict these outcomes are lacking. METHODS: Total hemorrhage volume following aneurysm rupture was retrospectively analyzed on presentation CT imaging using a custom semi-automated computer program developed in MATLAB that employs intensity-based k-means clustering to automatically separate blood voxels from other tissues. Volume data was added to a prospectively maintained SAH database. Through logistic regression analysis, we evaluated the association of hemorrhage volume with shunted-hydrocephalus and seizures and evaluated the diagnostic accuracy by evaluation of the area under the receiver operating characteristic curve (AUC). RESULTS: 288 consecutive patients with aSAH comprised the study population. Mean total hemorrhage volume was 74.9 ml. Thirty-eight patients developed seizures (13.2%). Mean hemorrhage volume in patients who developed seizures was significantly higher than patients with no seizures (mean difference 17.3 ml, P=0.01). In multivariate analysis, larger hemorrhage volume on initial CT scan and hemorrhage volume &gt;50 ml (OR 2.81, P=0.047 CI 1.03-7.80) were predictive of seizures. 48 patients developed shunt-dependent hydrocephalus (17%). The mean hemorrhage volume in patients who developed shunt-dependent hydrocephalus was significantly higher than patients who did not (mean difference 17.2 ml, P=0.006). Larger hemorrhage volume and hemorrhage volume &gt;50 ml (OR 2.45, P=0.03, CI 1.08-5.54) were predictive of shunt-dependent hydrocephalus. Hemorrhage volume had adequate discrimination for the development of seizures (AUC = 0.635) and shunted hydrocephalus (AUC = 0.629). CONCLUSION: Hemorrhage volume is an independent predictor of seizures and hydrocephalus in aSAH. Further evaluation of quantitative volumetric analysis may complement existing scales used in clinical practice and assist in prognostication and management.
Fünf‐ und sechsfach koordinierte Vinylruthenium‐ und ‐osmium‐Komplexe durch Alkin‐Insertion in Hydridometall‐Vorstufen (1989)

Abstract Die Carbonyl(hydrido)‐Komplexe MHCl(CO)[PMe( t Bu) 2 ] 2 ( 3 : M = Ru; 4 : M = Os) reagieren in hoher Ausbeute mit Alkinen RCCH (R = H, Me, Ph) unter Insertion zu den fünffach koordinierten Vinylmetall‐Verbindungen M( E ‐CHCHR)Cl(CO)[PMe( t Bu) 2 ] 2 ( 5 – 10 ). Auf ähnliche Weise werden bei Verwendung von MHCl(CO)(P i Pr 3 ) 2 ( 11, 12 ) und RuHCl(CO)(PPh 3 ) 3 ( 15 ) als Ausgangssubstanzen die Komplexe M( E ‐CHCHMe)Cl(CO)(P i Pr 3 ) 2 ( 13 , 14 ) und Ru( E ‐CHCHR)Cl(CO)(PPh 3 ) 2 ( 16 , 17 ) erhalten. Die Reaktionen von 3 , 4 und 12 mit HCCCO 2 Me führen ebenfalls zur Bildung von Vinylmetall‐Verbindungen, in denen die CO 2 Me‐Gruppe entweder an das α‐ oder β‐Kohlenstoff‐Atom des Vinyl‐Liganden gebunden ist. Die Kristallstruktur von ( 18 ) wurde bestimmt. Os( E ‐CHCHCO 2 Me)Cl(CO)(P i Pr 3 ) 2 ( 22 ) lagert sich in Lösung quantitativ in das Z ‐Isomere um, das eine chelatartig gebundene Vinyl‐Gruppe enthält. Die Hydrido‐ ( 3 , 4 ) und die Vinylmetall‐Verbindungen 5 – 10 , 13 , 16 und 31 reagieren mit Liganden L (CO, CNMe, CNCH 2 Ph und PMe 3 ) zu den entsprechenden oktaedrischen Ruthenium‐ und Osmium‐Komplexen 25 – 30 und 32 – 39 . Die Darstellung von [Ru( E ‐CHCHPh)(CO) 3 (P i Pr 3 ) 2 ]PF 6 ( 41 ) wird auch beschrieben.
Quantitative chemical shift-encoded MRI is an accurate method to quantify hepatic steatosis (2013)

Complex three-echo chemical shift-encoded MRI is equivalent to MRS for quantifying liver fat, but only with correction for T2* decay and T1 recovery and use of spectral modeling of fat. This is necessary because T2* decay, T1 recovery, and multispectral complexity of fat are processes which may otherwise bias the measurements.
Optimum design of actively controlled structures (1990)

Abstract The optimum design of seismic structures equipped with active controls is presented. The design variables are structural parameters, such as structural stiffness or moment of inertia. The optimization procedure is carried out in two stages. First, the optimal control forces are expressed in closed form, as implicit functions of the design variables. In the second stage, the structural parameters are varied in order to minimize a structural weight objective function. The algorithm is applied to structural systems under earthquake excitations, for displacement, frequency and control force constraints.
Theorizing the Mysteries' End in England, the Artificial Demonic, and the Sixteenth-Century Witch-Craze (1997)

As all readers familiar with the rise of Elizabethan drama know, the medieval religious drama supported and produced by the craft guilds sharply declined and died out between the middle and the end of the sixteenth century. Many once thought that this death was the natural outcome of an evolutionary aesthetic process: early mod ern theatergoers in England and in other parts of Europe had grown too sophisticated for such wooden and tedious fare.1 More recently, however, historians such as Harold C. Gardiner and Glynne Wick ham have offered more compelling explanations for the end of the re ligious drama in England. In short, the Reformation denigrated and expunged the papistical, superstitious, and Catholic forms of public expression. In the wake of an emerging Protestant ideology yoked to governmental policy, the themes of public theater were secularized; nationalism and recent history supplanted suspicious sacramentalism and biblical narrative.2 The death of the religious drama could be seen as part of a general iconoclasm towards visual, plastic, or verbal and performative idols; such iconoclasm and concomitant anxiety about representing the sacred constituted one of the Reformation's main cultural manifestations in England.3 The Reformation has served historians as the all-purpose, superor dinate cause of many local and particular cultural changes in early modern Europe, especially changes in the representation of the sa cred. Consequently, another cataclysmic phenomenon of the sixteenth and seventeenth centuries has been attributed to the Reformation: the
Ordinal regression increases statistical power to predict epilepsy surgical outcomes (2022)

Studies of epilepsy surgery outcomes are often small and thus underpowered to reach statistically valid conclusions. We hypothesized that ordinal logistic regression would have greater statistical power than binary logistic regression when analyzing epilepsy surgery outcomes. We reviewed 10 manuscripts included in a recent meta-analysis which found that mesial temporal sclerosis (MTS) predicted better surgical outcomes after a stereotactic laser amygdalohippocampectomy (SLAH). We extracted data from 239 patients from eight studies that reported four discrete Engel surgical outcomes after SLAH, stratified by the presence or absence of MTS. The rate of freedom from disabling seizures (Engel I) was 64.3% (110/171) for patients with MTS compared to 44.1% (30/68) without MTS. The statistical power to detect MTS as a predictor for better surgical outcome after a SLAH was 29% using ordinal regression, which was significantly more than the 13% power using binary logistic regression (paired t-test, P < .001). Only 120 patients are needed for this example to achieve 80% power to detect MTS as a predictor using ordinal regression, compared to 210 patients that are needed to achieve 80% power using binary logistic regression. Ordinal regression should be considered when analyzing ordinal outcomes (such as Engel surgical outcomes), especially for datasets with small sample sizes.
Analysis and Prediction of Constriction Resistance Between Coated Surfaces (2006)

Well-controlled and well-characterized experimental measurements are obtained during the melting of a moderate-Prandtl-number material (n-eicosane) in a cylindrical enclosure heated from the side. The study aims to provide benchmark experimental measurements for validation of numerical codes. Experimental results in terms of measured temperatures and melt front locations are reported in both graphical and tabular forms. The melt front was captured photographically and its location ascertained using digital image processing techniques. To facilitate numerical validation exercises, a complete set of experimental results have been made available on a website for public access. An illustrative numerical comparison exercise was also undertaken using a multiblock finite volume method and the enthalpy method for a range of Stefan numbers. The experimental boundary conditions can be adequately represented with a constant and uniform side wall temperature, a constant and uniform lower surface temperature, and an adiabatic top wall. Very good agreement was obtained between the predictions and the experiment for Stefan numbers of up to 0.1807. The experimental results for a Stefan number of 0.0836 are recommended as being the most suitable for numerical benchmarking, since the boundary conditions are best controlled in this set of experiments.
S533 Vibrating Capsule Is Efficacious in Patients With Severe Chronic Idiopathic Constipation (CIC) (2022)

Introduction: Approximately 50 million Americans report constipation, of whom 28% have moderately severe illness (Am J Gastro 2020;115:895-905). The effectiveness of current therapies for severe chronic idiopathic constipation (CIC) is unknown. In a recent Phase III trial, a vibrating capsule (VC) proved superior to placebo in improving bowel and abdominal symptoms in patients with CIC. Aim: To determine the efficacy and safety of VC in patients with severe CIC. Methods: We performed a post-hoc analysis of CIC patients (Rome III) who were enrolled in an 8-week phase 3, multicenter, double-blind trial, and randomly received one VC (Vibrant, Yokneam, Israel) or placebo orally for 5 days/week. Severe CIC was defined as patients who reported 0 complete spontaneous bowel movements (CSBM) during a 2-week baseline period on a daily electronic stool diary. Patients with history of dysphagia or bowel obstruction were excluded. Primary outcome measures were percentage of subjects with an increase of one (CSBM1), two (CSBM2), or three (CSBM3) CSBM/week, during at least 6 of 8 treatment weeks compared to baseline. Secondary outcomes and safety were also assessed. Results: 312 CIC patients were enrolled of whom 56% (VC n=89, placebo n=86) had severe CIC. There were significantly greater CSBM1 (p=0.0007), CSBM2 (p=0.0040), and CSBM3 (p=0.0176), responders in the VC group compared to placebo (Fig). The straining effort (p=0.0027) and stool consistency (p=< .0001) also improved significantly in the VC group compared to placebo. Also, QOL significantly improved in the VC group (p=< .0001) compared to placebo. The treatment was generally safe, without severe adverse events or diarrhea. The most common AEs in the group were a sensation of mild vibration (11.2%) and abdominal discomfort (2.25%), Table. Conclusion: In individuals with severe CIC, VC significantly improved bowel and abdominal symptoms and QOL compared to placebo. The VC was safe and well tolerated. Vibrating Capsule is a first in class, novel, non-pharmacological treatment that is efficacious and safe in patients with severe chronic constipation.Figure 1.: Primary outcome measures showing proportion of CSBMs responders with severe constipation Table 1. - Adverse events in severe CIC population Adverse event Vibrating Capsule, Mode 1(n=89)No. of patients (%) Placebo(n=86)No. of patients (%) Adverse events during treatment (combined safety populations including interim analysis groups).* Any event 23 (25.84) 15 (17.4) Sensation of vibration** 10 (11.24) Headache 1 (1.12) 1 (1.16) Urinary tract infection 1 (1.12) 1 (1.16) Abdominal pain 2 (2.23) Abdominal discomfort 2 (2.25) Vomiting 2 (2.25) 1 (1.16) Nausea 3 (3.37) 1 (1.16) Abdominal distention 2 (2.23) Diarrhea 2 (2.25) Covid-19 1 (1.12) 1 (1.16) Nasopharyngitis/Bronchitis 2 (2.25) Musculoskeletal 1 (1.16) *Data shown for adverse events in at least 1% of the subjects**Sensation of vibration means: “I think I felt vibration.”
Streptokinase in acute stroke (1998)

The Australian Streptokinase Trial was a randomized, double-blind, placebo-controlled trial, in which streptokinase (SK, 1.5 million IU I.V.) was given within 4 hours of stroke onset. In a subset of 37 patients, 99mTc-labeled D,L-hexamethylpropylene amine oxime single-photon emission computed tomography (SPECT) and/or transcranial Doppler (TCD) studies were performed before and after therapy to test the hypothesis that SK may improve the hemodynamic measures of reperfusion/recanalization rates (TCD parameter) within 24 hours. Eighteen patients received SK and 19 placebo. Baseline characteristics were similar in both groups, and there were no differences in clinical outcomes assessed at 3 months after stroke. Although there was no increase in the group mean perfusion defect or volume on SPECT after thrombolytic therapy, a larger number of patients demonstrating the combined end point of reperfusion or recanalization was seen in the SK group (13/14, 93%) than in the placebo group (7/14, 50%; p = 0.01). Although SK given within 4 hours of acute ischemic stroke appears to improve arterial patency/tissue reperfusion, this effect is neither early nor extensive enough to influence overall clinical outcome.
Purification of solanesyl-diphosphate synthase from Micrococcus luteus. A new class of prenyltransferase. (1991)

The activity of solanesyl-diphosphate synthase from Micrococcus luteus is stimulated by a high molecular mass fraction (HMF) which is separated from cell-free extracts of the same bacterium by DEAE-Toyopearl chromatography followed by Sephadex G-100 chromatography. By employing HMF in the assay procedure, solanesyl-diphosphate synthase was able to be purified to homogeneity and was found to be a homodimer with a monomeric molecular mass of 34 kDa. In contrast to hexaprenyl- and heptaprenyl-diphosphate synthases, which are composed of two easily dissociable components that are inactive unless combined, the homogeneously purified solanesyl-diphosphate synthase itself showed a catalytic activity, though weak, catalyzing the synthesis of both (all-E)-nonaprenyl-(solanesyl-) and (all-E)-octaprenyl diphosphate. HMF does not affect the stability of solanesyl-diphosphate synthase or Km values for isopentenyl diphosphate and farnesyl diphosphate, but it markedly increases Vmax values in a time-dependent manner. Several lines of evidence indicate that HMF contains a factor which binds to polyprenyl products and removes them out of the active site of enzyme to facilitate and maintain the turnover of catalysis.
A review on self‐healing polymers for applications in spacecraft and construction of roads (2022)

Abstract Self‐healing polymers ( SHP ) are the polymers that have the capability to recover the material from any physical damage by responding to the damages or cracks in the material and heal the same. This self‐healing technology gives the polymers ability to recover from the cracks at an early stage by preventing them from any catastrophic failures, which increases the scope of applications of these materials. This review article highlights the key points on extrinsic self‐healing polymer and intrinsic self‐healing polymer by comparing their healing efficiency, advantages, disadvantages, and challenges in the prospect of their future development as well as their possible applications in space industry and construction of roads.
DETAILED COMPONENT MODELLING OF A SELF-CENTERING ENERGY DISSIPATIVE BRACE SYSTEM (2014)

DETAILED COMPONENT MODELLING OF A SELF-CENTERING ENERGY DISSIPATIVE BRACE SYSTEM - 4th International Conference on Computational Methods in Structural Dynamics and Earthquake Engineering - 12-14 June 2013 - Kos Island Greece
Asymmetric synthesis of functionalized tertiary homoallyl alcohols by diastereoselective allylation of chiral .alpha.-keto amides derived from (S)-proline esters: control of stereochemistry based on saturated coordination of Lewis acid (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAsymmetric synthesis of functionalized tertiary homoallyl alcohols by diastereoselective allylation of chiral .alpha.-keto amides derived from (S)-proline esters: control of stereochemistry based on saturated coordination of Lewis acidKenso Soai and Miyuki IshizakiCite this: J. Org. Chem. 1986, 51, 17, 3290–3295Publication Date (Print):August 1, 1986Publication History Published online1 May 2002Published inissue 1 August 1986https://pubs.acs.org/doi/10.1021/jo00367a008https://doi.org/10.1021/jo00367a008research-articleACS PublicationsRequest reuse permissionsArticle Views440Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Mechanisms of large actuation strain in dielectric elastomers (2011)

Abstract Subject to a voltage, a dielectric elastomer (DE) deforms. Voltage‐induced strains of above 100% have been observed when DEs are prestretched, and for DEs of certain network structures. Understanding mechanisms of large actuation strains is an active area of research. We propose that the voltage‐stretch response of DEs may be modified by prestretch, or by using polymers with “short” chains. This modification results in suppression or elimination of electromechanical instability, leading to large actuation strains. We propose a method to select and design a DE, such that the actuation strain is maximized. The theoretical predictions agree well with existing experimental data. The theory may contribute to the development of DEs with exceptional performance. © 2011 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys, 2011
A New Method for the Synthesis of 2-Substituted 2-Buten-4-olide via α-Substituted β-Phenylthio-γ-butyrolactone (1979)

Abstract The addition reaction of lithium benzenethiolate to 2-buten-4-olide in the presence of aldehydes and ketones afforded α-substituted β-phenylthio-γ-butyrolactones (4a–f). The dehydrosulfenylation of 4a–d proceeded smoothly to give 2-substituted 2-buten-4-olide by the reflux of α-substituted β-phenylsulfinyl-γ-butyrolactone, which was prepared by the oxidation of 4a–d, in the presence of triethylamine.
FUNCTIONAL RESPONSES OF T CELLS BLOCKED BY ANTI-CD25 ANTIBODY THERAPY DURING CARDIAC REJECTION (2000)

Treatment with anti-CD25 mAbs cannot provide complete suppression of T-cell function because significant numbers of IL-2- and IL-15-responsive T cells remain present in the peripheral blood of allograft recipients during anti-CD25 mAb treatment.
Stellate Ganglion Block as Therapy for Uncontrollable Ventricular Fibrillation in an LVAD Patient (2015)

Objectives: Severe ischemic cardiomyopathy is a main cause for implantation of left ventricular assist devices (LVAD). Despite permanent support of the left ventricle, patients remain dependent on sufficient right heart function. Severe ventricular arrhythmia may significantly impact right ventricular output, resulting in reduced LVAD flow and insufficient circulation.
[Immediate allergy to latex. 12 cases]. (1989)

Immediate hypersensitivity to latex is now well known. Contact urticaria is the most common manifestation, sometimes associated with rhinitis, asthma or a generalized rash. Atopy and frequent contact with latex favor sensitization. Anaphylactic shock is to be feared in sensitized patients during contact with latex, especially in peroperative situations (latex surgical gloves), as in the 12 cases reported. The shock is unusual in its delayed appearance and its progressive course. Positive skin tests to latex, the presence of specific IgE antibodies and negative skin tests to anesthetics confirm the diagnosis. However, the latex allergen has not yet been identified. Due to the increasing use of protective rubber (gloves, condoms, etc), the frequency of latex sensitization should increase. Systematic screening during history taking will be important before treatment.
Kinetic Modeling of the Release of Ethylene Oxide from Sterilized Plastic Containers and its Interaction with Monoclonal Antibodies (2017)

Ethylene oxide (ETO) is commonly used to sterilize plastic containers, but the effects of residual amounts left after sterilization on protein therapeutics are still not well understood. Here we describe experiments exploring the factors that influence concentrations of ETO migrating from ETO-treated plastic containers into aqueous solution over time. Additionally, interactions of ETO with model antibodies were studied, with ETO adducts found on all methionine residues when incubated in solutions spiked with ETO at concentrations that could potentially be reached in ETO-treated plastic vials. Overall, the likelihood of observable ETO-protein modifications upon storage in ETO-sterilized containers will depend on a complex interplay of protein properties, formulation details, storage conditions, and amount of residual ETO initially in the container.