gebhart/patrepeval huggingface dataset:
ANG II-induced hypertension in the VCD mouse model of menopause is prevented by estrogen replacement during perimenopause (2015)

Premenopausal females are resistant to the development of hypertension, and this protection is lost after the onset of menopause, resulting in a sharp increase in disease onset and severity. However, it is unknown how a fluctuating ovarian hormone environment during the transition from perimenopause to menopause impacts the onset of hypertension, and whether interventions during perimenopause prevent disease onset after menopause. A gradual transition to menopause was induced by repeated daily injections of 4-vinylcyclohexene diepoxide (VCD). ANG II (800 ng·kg(-1)·min(-1)) was infused into perimenopausal and menopausal female mice for 14 days. A separate cohort of mice received 17β-estradiol replacement during perimenopause. ANG II infusion produced significantly higher mean arterial pressure (MAP) in menopausal vs. cycling females, and 17β-estradiol replacement prevented this increase. In contrast, MAP was not significantly different when ANG II was infused into perimenopausal and cycling females, suggesting that female resistance to ANG II-induced hypertension is intact during perimenopause. ANG II infusion caused a significant glomerular hypertrophy, and hypertrophy was not impacted by hormonal status. Expression levels of aquaporin-2 (AQP2), a collecting duct protein, have been suggested to reflect blood pressure. AQP2 protein expression was significantly downregulated in the renal cortex of the ANG II-infused menopause group, where blood pressure was increased. AQP2 expression levels were restored to control levels with 17β-estradiol replacement. This study indicates that the changing hormonal environment in the VCD model of menopause impacts the severity of ANG II-induced hypertension. These data highlight the utility of the ovary-intact VCD model of menopause as a clinically relevant model to investigate the physiological mechanisms of hypertension that occur in women during the transition into menopause.
Identification of Sagging Aerial Cable Section by Distributed Vibration Sensing based on OFDR (2019)

We measure vibration waveforms along an installed aerial optical fiber cable and identify a sagging cable section. This is the first demonstration of telecom optical fiber cable maintenance by distributed vibration sensing.
Cuckoo algorithm with great deluge local-search for feature selection problems (2022)

&lt;p class="Abstract"&gt;&lt;span lang="EN-US"&gt;Feature selection problem is concerned with searching in a dataset for a set of features aiming to reduce the training time and enhance the accuracy of a classification method. Therefore, feature selection algorithms are proposed to choose important features from large and complex datasets. The cuckoo search (CS) algorithm is a type of natural-inspired optimization algorithms and is widely implemented to find the optimum solution for a specified problem. In this work, the cuckoo search algorithm is hybridized with a local search algorithm to find a satisfactory solution for the problem of feature selection. The great deluge (GD) algorithm is an iterative search procedure, that can accept some worse moves to find better solutions for the problem, also to increase the exploitation ability of CS. The comparison is also provided to examine the performance of the proposed method and the original CS algorithm. As result, using the UCI datasets the proposed algorithm outperforms the original algorithm and produces comparable results compared with some of the results from the literature.&lt;/span&gt;&lt;/p&gt;
Histocompatibility Testing (1993)

Abstract Successful transplantation depends on the minimization of immunological differences between the donor and recipient tissues. These differences are based on polymorphisms of the human major histocompatibility complex and play a major role in determining the acceptance or rejection of allografts during transplantation. Histocompatibility Testing: A Practical Approach describes methods for the investigation of these polymorphisms at the gene and protein levels and their application to the clinical transplanation of human organs and bone marrow. There is currently no other text available covering these up-to-date serological and molecular techniques in this area of immunogenetics, despite their importance to fundamental research, clinical practice and forensic medicine. This book will therefore be of great interest to researchers in many subject areas, irrespective of whether they are in established laboratories or are entering this field for the first time.
The Bark of Robinia pseudoacacia Contains a Complex Mixture of Lectins (Characterization of the Proteins and the cDNA Clones) (1995)

Two lectins were isolated from the inner bark of Robinia pseudoacacia (black locust). The first (and major) lectin (called RPbAI) is composed of five isolectins that originate from the association of 31.5- and 29-kD polypeptides into tetramers. In contrast, the second (minor) lectin (called RPbAII) is a hometetramer composed of 26-kD subunits. The cDNA clones encoding the polypeptides of RPbAI and RPbAII were isolated and their sequences determined. Apparently all three polypeptides are translated from mRNAs of approximately 1.2 kb. Alignment of the deduced amino acid sequences of the different clones indicates that the 31.5- and 29-kD RPbAI polypeptides show approximately 80% sequence identity and are homologous to the previously reported legume seed lectins, whereas the 26-kD RPbAII polypeptide shows only 33% sequence identity to the previously described legume lectins. Modeling the 31.5-kD subunit of RPbAI predicts that its three-dimensional structure is strongly related to the three-dimensional models that have been determined thus far for a few legume lectins. Southern blot analysis of genomic DNA isolated from Robinia has revealed that the Robinia bark lectins are the result of the expression of a small family of lectin genes.
Crystal structure of a new calix[4]arene-crown including a diphenylenespacer, C68H68O12·2CH3COCH3 (1999)

C74H80014, triclinic, PI (No. 2), a = 10.2616(8) k,b = 14.652(2) , c = 21.824(3) , a= 102.612(1), = 99.963(1), = 98.882(1), V= 3090.2 3 , Z = 2, Rg{F) = 0.091,Rw(F) = 0.223, T= 123 K.
Coupled Transmission Line Networks in an Inhomogeneous (1969)

Absfract—In this paper, two-port networks composed of two identical, coupled transmission lines embedded in MI inhomogeneous dielectric (e.g., suspended substrate, microstrip) are investigated. The AB CD parameters of circoit conflgnrations, considered by Jones and Bolljahn [1], are obtained for the case of inhomogeneous dielectilc. Equivalent circoits of these networks are also given. It is shown that the characteristics of such circnits dilfer markedly from those embedded in a homogeneous medium. In addition, experimental results are presented for three types of circoits which have been constructed and tested. There is excellent agreement between the experimental resolts and those predicted theoretically on the basis of the equivalent circuits. HE PURPOSE of this paper is to examine the nature of the electromagnetic coupling which exists between parallel conductors in an inhomogeneous dielectric such as the suspended substrate. In particular, we consider the network structures that are obtained from two identical coupled lines by placing open or short circuits on various terminal pairs or connecting together two terminals. These circuits were investigated by Jones and Bolljahn [1], in a homogeneous dielectric environment. It is found that the characteristics of coupled-line circuits in a suspended substrate configuration may differ markedly from those in a homogeneous medium. This difference in behavior is due to the fact that the even and odd mode signals, which are commonly used in the analysis of such coupled lines, propagate with unequal phase velocities. This difference in phase velocities precludes a pure TEM wave propagation. It is known, however, that the TEM approximation yields excellent results to several gigahertz and it will be used throughout this analysis. In order to derive the parameters of the two-port circuits, one considers first the current and voltage relationships which exist on a pair of infinitely long transmission lines. These equations are available in the literature, e.g., Rice [2], Vlostovskiy [3], and Murray [4]. The current–voltage relationships may be cast in the form of impedance, admittance, and chain matrices. The descriptions of the various circuit configurations are then derived by an application of the appropriate boundary conditions. For quantitative results the even and odd mode propagation constants and characteristic impedances must be obtained numerically first. This can be done by a method developed by Smith [5] whose results are used here.
POLEandPOLD1screening in 155 patients with multiple polyps and early-onset colorectal cancer (2017)

Germline mutations in POLE and POLD1 have been shown to cause predisposition to colorectal multiple polyposis and a wide range of neoplasms, early-onset colorectal cancer being the most prevalent. In order to find additional mutations affecting the proofreading activity of these polymerases, we sequenced its exonuclease domain in 155 patients with multiple polyps or an early-onset colorectal cancer phenotype without alterations in the known hereditary colorectal cancer genes. Interestingly, none of the previously reported mutations in POLE and POLD1 were found. On the other hand, among the genetic variants detected, only two of them stood out as putative pathogenic in the POLE gene, c.1359 + 46del71 and c.1420G > A (p.Val474Ile). The first variant, detected in two families, was not proven to alter correct RNA splicing. Contrarily, c.1420G > A (p.Val474Ile) was detected in one early-onset colorectal cancer patient and located right next to the exonuclease domain. The pathogenicity of this change was suggested by its rarity and bioinformatics predictions, and it was further indicated by functional assays in Schizosaccharomyces pombe. This is the first study to functionally analyze a POLE genetic variant outside the exonuclease domain and widens the spectrum of genetic changes in this DNA polymerase that could lead to colorectal cancer predisposition.
Mise en évidence et caractérisation d'un système enzymatique bactérien pouvant ouvrir l'hétérocycle aromatique du N-méthyl pyridinium (1982)

Une souche de Pseudomonas aeruginosa fut isolé à partir d'échantillons de sol. Cette souche peut croître dans un milieu ne contenant que les sels essentiels et du chlorure de N-méthyl pyridinium. Cette souche peut ouvrir le cycle aromatique du NMP-Cl et l 'utiliser comme source de carbone et d'azote. Le système enzymatique responsable de l'ouverture du cycle se localise dans la membrane plasmatique et a les propriétés des protéines membranaires intrinsèques. Nous l'avons solubilisé à i 'aide de détergent à partir des membranes purifiées obtenues par ultracentrifugation sur gradient discontinu. Le système enzymatique purifié, soit soluble ou encore intègre dans la membrane démontre une activité envers le NMP-Cl de plus de cent fois supérieure à celle des bactéries en culture. Ce système enzymatique ne peut cependant ouvrir l'hétérocycle aromatique d'acides aminés comme la desmosine ou l'isodesmosine. De plus, la présence de ces acides aminés inhibe fortement l'activité du système envers le NMP-Cl.
Erythrocyte microparticles can induce kidney vaso-occlusions in a murine model of sickle cell disease (2012)

Patients with sickle cell disease suffer from painful crises associated with disseminated vaso-occlusions, increased circulating erythrocyte microparticles (MPs), and thrombospondin-1 (TSP1). MPs are submicron membrane vesicles shed by compromised or activated cells. We hypothesized that TSP1 mediates MP shedding and participates in vaso-occlusions. We injected TSP1 to transgenic SAD mice with sickle cell disease and characterized circulating phosphatidylserine+ MPs by FACS. TSP1 stimulated MPs in plasma and initiated vaso-occlusions within minutes. In vitro, TSP1 triggered rapid erythrocyte conversion into spicule-covered echinocytes, followed by MP shedding. MP shedding was recapitulated by peptides derived from the TSP1 carboxyterminus. We purified MPs shed by erythrocytes in vitro and administered them back to SAD mice. MPs triggered immediate renal vaso-occlusions. In vitro, MPs triggered the production of radical oxygen species by endothelial monolayers, favored erythrocyte adhesion, and induced endothelial apoptosis. MPs also compromised vasodilation in perfused microvessels. These effects were inhibited by saturating MP phosphatidylserine with annexin-V, or with inhibitors of endothelial ROS production. We conclude that TSP1 triggers erythrocyte MP shedding. These MPs induce endothelial injury and facilitate acute vaso-occlusive events in transgenic SAD mice. This work supports a novel concept that toxic erythrocyte MPs may connect sickle cell anemia to vascular disease.
Engineering translocations with delayed replication: evidence for cis control of chromosome replication timing (2005)

Certain chromosome rearrangements, found in cancer cells or in cells exposed to ionizing radiation, exhibit a chromosome-wide delay in replication timing (DRT) that is associated with a delay in mitotic chromosome condensation (DMC). We have developed a chromosome engineering strategy that allows the generation of chromosomes with this DRT/DMC phenotype. We found that approximately 10% of inter-chromosomal translocations induced by two distinct mechanisms, site-specific recombination mediated by Cre or non-homologous end joining of DNA double-strand breaks induced by I-Sce1, result in DRT/DMC. Furthermore, on certain balanced translocations only one of the derivative chromosomes displays the phenotype. Finally, we show that the engineered DRT/DMC chromosomes acquire gross chromosomal rearrangements at an increased rate when compared with non-DRT/DMC chromosomes. These results indicate that the DRT/DMC phenotype is not the result of a stochastic process that could occur at any translocation breakpoint or as an epigenetic response to chromosome damage. Instead, our data indicate that the replication timing of certain derivative chromosomes is regulated by a cis-acting mechanism that delays both initiation and completion of DNA synthesis along the entire length of the chromosome. Because chromosomes with DRT/DMC are common in tumor cells and in cells exposed to ionizing radiation, we propose that DRT/DMC represents a common mechanism responsible for the genomic instability found in cancer cells and for the persistent chromosomal instability associated with cells exposed to ionizing radiation.
Latent Infection of a New Alphanodavirus in an Insect Cell Line (2007)

Insect BTI-TN-5B1-4 (Tn5) cells have been used extensively with recombinant baculoviruses to express foreign genes. When a recombinant baculovirus containing the hepatitis E virus capsid protein gene was used to infect Tn5 cells, unknown virus particles in addition to the anticipated hepatitis E virus-like particles were produced in the infected cells. The unknown virus particles were 35 nm in diameter and contained RNA that was highly homologous to full-length RNA1 (3,107 bp) and RNA2 (1,383 bp) genomic RNAs of flock house virus. Surprisingly, both RNAs seen in these induced nodavirus particles could be amplified from commercially available Tn5 cells without infection with or induction by a baculovirus. The nucleotide sequences from the purified nodavirus particles and the normal Tn5 cells were identical, demonstrating that the Tn5 cells themselves were latently infected with a nodavirus. However, the generation of nodavirus particles was significantly stimulated by infection with recombinant baculoviruses. Phylogenetic analysis suggested that this new nodavirus belongs to the genus Alphanodavirus in the family Nodaviridae.
Glycolipids as potential immunologic adjuvants (1980)

A group of 1-thio-beta-L-fucopyranosides containing hexadecane, 9-octadecene, adamantane, 1,2-diphenyltetrafluoroethane, and 3-hexynyl- and 3,6-dioxaoctylcholesterols were synthesized as potential immunologic adjuvants. Many of these fucosyl lipids and 6-(5-cholesten-3 beta-yloxy)hexyl 1 thioglycosides were found to give good response to subunit A/Victoria influenza virus. Carbohydrates with L-fucose and D-galactose backbones appeared essential for adjuvant activity. Lactose which has a terminal D-galactose moiety was found to be active, whereas L-arabinose which lacks a 5-(hydroxymethyl) group was inactive.
Obesity epidemic has emerged among Nigerians (2014)

About two-thirds of urban, professional, high socio-economic status Nigerian adults are either overweight or obese. The prevalence of overweight and obesity among this population of adult Nigerians, is as high as it is in the United Kingdom. Female gender and older age were independent predictors of overweight and obesity; while middle or high socio-economic status were independently associated with obesity.
Formation and disappearance of free radicals, and the micellar equilibrium in the detergent sodium 4-(6'-dodecyl)benzenesulfonate (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFormation and disappearance of free radicals, and the micellar equilibrium in the detergent sodium 4-(6'-dodecyl)benzenesulfonateA. Henglein and Th. ProskeCite this: J. Am. Chem. Soc. 1978, 100, 12, 3706–3709Publication Date (Print):June 1, 1978Publication History Published online1 May 2002Published inissue 1 June 1978https://pubs.acs.org/doi/10.1021/ja00480a008https://doi.org/10.1021/ja00480a008research-articleACS PublicationsRequest reuse permissionsArticle Views50Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Development of an UV scanning photoluminescence apparatus for SiC characterization (2002)

We have adapted a scanning photoluminescence (SPL) apparatus, previously developed for III-V compounds analysis, for the characterization of SiC. The PL mapping is obtained by scanning the sample, fixed to an x-y stage with 1 μm minimal step, under a doubled Ar+ laser beam (244 nm) focused by a microscope objective (×52). For this excitation the spot diameter is about 4 μm. The PL signal can be either directly detected, giving integrated PL intensity, either dispersed using a monochromator, giving spectrally resolved PL (1 nm resolution). The measurements can be realized at room temperature for near band edge studies, or at low temperature (80 K) for deep defects investigation. The gettering effect of non radiative centres by the screw dislocations in 6H-SiC is evidenced using this apparatus.
Abstract 9341: Hepatic Steatosis Index and Fibrosis-4 Scores in Patients With Type 2 Diabetes - Post Hoc Analyses from VERTIS CV (2021)

Introduction: Given the potential link between non-alcoholic fatty liver disease and increased cardiovascular (CV) risk, the associations between markers of hepatic steatosis/fibrosis with CV and kidney outcomes were explored. Methods: These post hoc analyses were conducted on data from the VERTIS CV trial that randomized patients with type 2 diabetes (T2D) and atherosclerotic CV disease (ASCVD) to ertugliflozin 5 or 15 mg or placebo, with all randomized groups pooled for the present analyses. The presence of hepatic steatosis was estimated by hepatic steatosis index (HSI; 8 х ALT/AST + BMI + 2 if T2D + 2 if female); and for hepatic fibrosis, fibrosis-4 score (FIB-4; [age х AST]/[platelets count х √ALT]). Patients were divided into quartiles (Q1 to Q4) according to baseline for each score. CV and kidney outcomes (CV death/myocardial infarction/stroke [MACE]; hospitalization for heart failure [HHF]/CV death; CV death; HHF; and sustained ≥40% decrease in eGFR from baseline/dialysis or transplantation/kidney death) were stratified by baseline HSI and FIB-4 quartiles. Results: Among 8246 patients, the mean age was 64.4 years, mean BMI 32.0 kg/m 2 , mean HSI 44.0, and mean FIB-4 score 1.34. Event rates of MACE, HHF/CV death, CV death, and HHF increased with FIB-4 quartile ( Fig A ). The hazard ratios (HR, 95% CI) of events by FIB-4 quartile (Q4 vs Q1) were 1.48 (1.25, 1.76), 2.0 (1.63, 2.51), 1.85 (1.45, 2.36), and 2.94 (1.98, 4.37) for MACE, HHF/CV death, CV death, and HHF, respectively. The kidney composite did not differ across FIB-4 quartiles. CV and kidney outcomes did not differ across HSI quartiles, except for higher incidence of HHF in the upper HSI quartile (HR [95% CI], Q4 vs Q1: 1.52 [1.07, 2.17]) ( Fig B ). Conclusion: In VERTIS CV, baseline fibrosis scores were associated with incident CV events in patients with T2D and ASCVD, despite the upper cutoff excluding advanced fibrosis. Steatosis only correlated with HHF, and neither measure was associated with the composite kidney outcome.
Serotonin Transporter Gene Polymorphic Element <i>5-HTTLPR</i> Increases the Risk of Sporadic Parkinson’s Disease in Italy (2009)

Parkinson's disease (PD) is a neurodegenerative disorder causing muscular rigidity, resting tremor and bradykinesia. We conducted an association study assessing how PD risk in Italy was influenced by the serotonin transporter gene (SLC6A4) polymorphic region 5-HTTLPR, consisting of an insertion/deletion (long allele-L/short allele-S) of 43 bp in the SLC6A4 promoter region. The SLC6A4 promoter single nucleotide polymorphism rs25531(A-->G) was evaluated too. We collected 837 independent subjects (393 PD, 444 controls). An association between the 5-HTTLPR polymorphism and risk of PD (S/S genotype OR [95% CI]: 1.7[1.2-2.5], p = 0.002) was found. The rs25531 and the haplotype 5-HTTLPR/rs25531 did not associate with risk of PD. Our data indicate that the 5-HTTLPR polymorphic element within the SLC6A4 promoter may govern the genetic risk of PD in Italians.
Cardio Metabolic Syndrome: A Global Epidemic (2015)

Cardio Metabolic Syndrome (CMS), also known as insulin resistance syndrome or metabolic syndrome X, is a combination of metabolic disorders or risk factors that essentially includes a combination of diabetes mellitus, systemic arterial hypertension, central obesity and hyper-lipidemia. Common to these diseases of metabolism is the associated development of atherosclerotic cardiovascular disease (ASCVD). Studies have shown a strong link between CMS and increased prevalence of peripheral vascular diseases, coronary artery disease and myocardial infarctions as well as cerebro-vascular arterial diseases and stroke.