gebhart/patrepeval huggingface dataset:
<title>Frame of wavelets for edge detection</title> (1994)

We present in the following work, a multiscale edge detection algorithm whose aim is to detect edges of any slope. Our work is based on a generalization of the Canny-Deriche filter, modelized by a more realistic edge than the traditional step shape edge. The filter impulse response is used to generate a frame of wavelets. For the merging of the wavelet coefficients, we use a geometrical classifier developed in our laboratory. The segmentation system thus set up and after the training phase does not require any adjustment nor parameter. The main original property of this algorithm is that it leads to a binary edge image without any threshold setting.
Prevention of murine antiphospholipid syndrome by BAFF blockade (2008)

Our findings suggest that aCL are generated in the germinal center, which is relatively independent of BAFF. Effector function of antiplatelet antibodies was only modestly affected by BAFF blockade. In contrast, myocardial infarctions were prevented, suggesting that triggering of thromboses requires both autoantibodies and mediators of inflammation. Similarly, renal damage requires both immune complexes and effector cells. The dissociation between autoantibody production and inflammation that may occur with B cell-depleting therapies underscores the role of B cells as effector cells in the autoimmune response.
Insight into lithium-ion mobility in Li2La(TaTi)O7 (2018)

Using experimental and computational methods, lithium ion mobility and the pathways for lithium conduction in Li<sub>2</sub>La(TaTi)O<sub>7</sub> have been studied.
The dopamine D1 receptor family: Structural and functional aspects (1996)

Conference Article| February 01 1996 The dopamine D1 receptor family: Structural and functional aspects A. A. Jensen; A. A. Jensen ∗Departments of Molecular Pharmacology, Health Care Chemistry, Novo Nordisk, Drug Discovery, Novo Allé, DK-2880 Bagsvaerd, Denmark Search for other works by this author on: This Site PubMed Google Scholar U. B. Pedersen; U. B. Pedersen ∗Departments of Molecular Pharmacology, Health Care Chemistry, Novo Nordisk, Drug Discovery, Novo Allé, DK-2880 Bagsvaerd, Denmark Search for other works by this author on: This Site PubMed Google Scholar N. Din; N. Din †Departments of Molecular Genetics, Novo Nordisk, Drug Discovery, Novo Allé, DK-2880 Bagsvaerd, Denmark Search for other works by this author on: This Site PubMed Google Scholar P. H. Andersen P. H. Andersen § ∗Departments of Molecular Pharmacology, Health Care Chemistry, Novo Nordisk, Drug Discovery, Novo Allé, DK-2880 Bagsvaerd, Denmark‡Departments of Health Care Chemistry, Novo Nordisk, Drug Discovery, Novo Allé, DK-2880 Bagsvaerd, Denmark §To whom correspondence should be addressed. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1996) 24 (1): 163–169. https://doi.org/10.1042/bst0240163 Article history Received: August 14 1995 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation A. A. Jensen, U. B. Pedersen, N. Din, P. H. Andersen; The dopamine D1 receptor family: Structural and functional aspects. Biochem Soc Trans 1 February 1996; 24 (1): 163–169. doi: https://doi.org/10.1042/bst0240163 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: G-protein, guanine nucleotide-binding protein, PKA, protein kinase A, β-ARK, β-adrenoceptor kinase, COS-7 cells, African green monkey kidney cells, BHK cells, baby hamster kidney cells, CHO cells, Chinese hamster ovary cells, PI; phosphatidylinositol, 293 cells, human embryonic cells, GH4 cells, rat pituitary GH4C1 cells, Lkt- cells, mouse Lkt- fibroblast cells This content is only available as a PDF. © 1996 Biochemical Society1996 Article PDF first page preview Close Modal You do not currently have access to this content.
Jean Baubérot, Philippe Portier, Jean-Paul Willaime (dir.), La Sécularisation en question. Religions et laïcités au prisme des sciences sociales (2019)

Cet ouvrage publié dans la collection « Bibliothèque de science politique » des Classiques Garnier est imposant à plus d’un titre. Il l’est d’abord par son format (746 pages), sa table des matières (53 auteurs pour 44 contributions), son poids (presque 1 kilogramme) et son prix (49 euros) ! Il l’est ensuite par la diversité des contributions et l’ampleur du paysage intellectuel qu’il présente. Et il l’est enfin par son objet, que précise le sous-titre Religions et laïcités au prisme des scien...
Room-temperature continuous-wave operation in the telecom wavelength range of GaSb-based lasers monolithically grown on Si (2017)

We report on electrically pumped GaSb-based laser diodes monolithically grown on Si and operating in a continuous wave (cw) in the telecom wavelength range. The laser structures were grown by molecular-beam epitaxy on 6°-off (001) substrates. The devices were processed in coplanar contact geometry. 100 μm × 1 mm laser diodes exhibited a threshold current density of 1 kA/cm−2 measured under pulsed operation at 20 °C. CW operation was achieved up to 35 °C with 10 μm × 1 mm diodes. The output power at 20 °C was around 3 mW/uncoated facet, and the cw emission wavelength 1.59 μm, in the C/L-band of telecom systems.
(Molecular analysis of cytoplasmic male sterility) (1991)

We have determined the actual RNA sequence of four mitochondrial genes: pcf, nad3, rps12, and coxII. Because plant mitochondrial proteins cannot be predicted from DNA sequences, the actual primary structures of the encoded proteins were unknown. We have gained information concerning the process of RNA editing. Editing can occur before splicing. Our data is consistent with the hypothesis that RNA editing is not simultaneous with transcription. Unlike other systems, the process of editing in plant does not exhibit a discernable direction. As a result of our RNA editing studies, we have produced a number of clones of the proper coding regions tube used for incorporating these mitochondrial genes into the nucleus. 6 refs., 4 figs.
A homozygous mutation of GNRHR in a familial case diagnosed with polycystic ovary syndrome (2017)

This is the first description of a <i>GNRHR</i> gene mutation in patients diagnosed with PCOS. Although we do not exclude a possible interaction of the identified variant with the genetic background and/or the environment, our result suggests that genetic alterations in the hypothalamo-pituitary axis may play role in the pathogenesis of PCOS.
Ring-LWE Ciphertext Compression and Error Correction: Tools for Lightweight Post-Quantum Cryptography. (2016)

Some lattice-based public key cryptosystems allow one to transform ciphertext from one lattice or ring representation to another efficiently and without knowledge of public and private keys. In this work we explore this lattice transformation property from cryptographic engineering viewpoint. We apply ciphertext transformation to compress Ring-LWE ciphertexts and to enable efficient decryption on an ultra-lightweight implementation targets such as Internet of Things, Smart Cards, and RFID applications. Significantly, this can be done without modifying the original encryption procedure or its security parameters. Such flexibility is unique to lattice-based cryptography and may find additional, unique real-life applications.Ciphertext compression can significantly increase the probability of decryption errors. We show that the frequency of such errors can be analyzed, measured and used to derive precise failure bounds for n-bit error correction. We introduce XECC, a fast multi-error correcting code that allows constant time implementation in software.We use these tools to construct and explore TRUNC8, a concrete Ring-LWE encryption and authentication system. We analyze its implementation, security, and performance. We show that our lattice compression technique reduces ciphertext size by more than 40% at equivalent security level, while also enabling public key cryptography on previously unreachable ultra-lightweight platforms.The experimental public key encryption and authentication system has been implemented on an 8-bit AVR target, where it easily outperforms elliptic curve and RSA-based proposals at similar security level. Similar results have been obtained with a Cortex M0 implementation. The new decryption code requires only a fraction of the software footprint of previous Ring-LWE implementations with the same encryption parameters, and is well suited for hardware implementation.
Estimating and interpreting the instantaneous frequency of a signal. II. Algorithms and applications (1992)

For pt.I see ibid., vol.80, no.4, p.520-38 (1992). The concept of instantaneous frequency (IF) is extended to discrete-time signals. The specific problem explored is that of estimating the IF of frequency-modulated (FM) discrete-time signals embedded in Gaussian noise. Well-established methods for estimating the IF include differentiation of the phase and smoothing thereof, adaptive frequency estimation techniques such as the phase locked loop (PLL), and extraction of the peak from time-varying spectral representations. More recently, methods based on a modeling of the signal phase as a polynomial have been introduced. These methods are reviewed, and their performance compared on both simulated and real data. Guidelines are given as to which estimation method should be used for a given signal class and signal-to-noise ratio (SNR).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A level-set method for shape optimization (2002)

We study a level-set method for numerical shape optimization of elastic structures. Our approach combines the level-set algorithm of Osher and Sethian with the classical shape gradient. Although this method is not specifically designed for topology optimization, it can easily handle topology changes for a very large class of objective functions. Its cost is moderate since the shape is captured on a fixed Eulerian mesh.
Identification and characterization of a novel isoform of the vesicular γ-aminobutyric acid transporter with glucose-regulated expression in rat islets (2006)

Pancreatic islets are unique outside the nervous system in that they contain high levels of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), synthesized by the enzyme glutamic acid decarboxylase (GAD). Since the role that GABA plays in the islet and the mechanisms whereby the two major GAD isoforms (GAD65 and GAD67) function as diabetes-associated autoantigens are unknown, continued characterization of the islet GAD-GABA system is important. We previously demonstrated that the GABA and glycine transporter vesicular inhibitory amino acid transporter (VIAAT also known as VGAT) is present in rat islets. Here we identify a novel 52 kDa variant of VIAAT in rat islets: VIAAT-52 (V52). V52 is an amino-terminally truncated form of VIAAT (V57) that likely results from utilization of a downstream start site of translation. V57 and V52 display different patterns of post-translational modification and cellular expression. Our results have indicated that islet content of V52, but not V57, is responsive to changes in glucose concentration and other extracellular conditions. VIAAT is expressed in the islet alpha cells, but there have been conflicting findings regarding the presence of VIAAT in the beta cells. Here we have also provided additional evidence for the presence of VIAAT in islet beta cells and show that the beta cell line INS-1 expresses V57. V52 may be better adapted than V57 to the unique rat alpha cell GAD-GABA system, which lacks GAD65 and in which VIAAT traffics to secretory granules rather than just to synaptic microvesicles.
Enzyme‐Catalyzed Laurolactam Synthesis via Intramolecular Amide Bond Formation in Aqueous Solution (2011)

Abstract Lactam formation from ω‐aminocarboxylic acids is thermodynamically unfavored in aqueous solution and therefore hard to achieve. In the present work ω‐laurolactam hydrolases from Acidovorax sp. T31 and Cupriavidus sp. U124 were investigated regarding their potential to catalyze lactam formation. Both enzymes are known to hydrolyze laurolactam to 12‐aminododecanoic acid. The ω‐laurolactam hydrolase genes were expressed in Escherichia coli BL21 (DE3) and the catalytic activity of the respective proteins was investigated. As expected from thermodynamics, only laurolactam hydrolysis but not 12‐aminododecanoic acid cyclization was observed in whole‐cell biotransformations and cell extract assays. The utilization of 12‐aminododecanoic acid methyl ester, as an activated form of 12‐aminododecanoic acid, resulted in intramolecular amide bond formation with the product laurolactam. Maximum laurolactam formation rates of 13.5 and 14.3 U g CDW −1 and molar yields of 11.5% and 13.0% were achieved in biotransformations at pH 10 with recombinant E. coli harboring the ω‐laurolactam hydrolase from Cupriavidus sp. U124 and Acidovorax sp. T31, respectively. Furthermore, it was shown that under the harsh reaction conditions applied, the utilization of whole‐cell biocatalysts enables 17.2‐fold higher laurolactam formation activity in comparison to free enzymes in solution. This study shows that hydrolase‐catalyzed laurolactam synthesis can be achieved in aqueous solution by selection of an appropriate substrate and reaction pH.
First-Principles Design of Graphene-Based Active Catalysts for Oxygen Reduction and Evolution Reactions in the Aprotic Li–O2 Battery (2016)

Using first-principles density functional theory (DFT) calculations, we demonstrate that catalytic activities toward oxygen reduction and evolution reactions (ORR and OER) in a Li-O2 battery can be substantially improved with graphene-based materials. We accomplish the goal by calculating free energy diagrams for the redox reactions of oxygen to identify a rate-determining step controlling the overpotentials. We unveil that the catalytic performance is well described by the adsorption energies of the intermediates LiO2 and Li2O2 and propose that graphene-based materials can be substantially optimized through either by N doping or encapsulating Cu(111) single crystals. Furthermore, our systematic approach with DFT calculations applied to design of optimum catalysts enables screening of promising candidates for the oxygen electrochemistry leading to considerable improvement of efficiency of a range of renewable energy devices.
Self-Aligned Wafer-Level Integration Technology With High-Density Interconnects and (2007)

This paper presents a polymer-based wafer-level in- tegration technology suitable for integrating RF and mixed-signal circuits and systems. In this technology, disparate dies can be integrated together using a batch fabrication process. Very high density die-to-die interconnects with widths currently as small as 25 m are implemented. To demonstrate the capabilities of this technology, a 10-GHz receiver front-end implemented in 0.18- m CMOS technology is integrated with a high-resistivity Si substrate and embedded passives. By adjusting the input matching of the receiver using the embedded passives fabricated on the high-resis- tivity Si substrate, the input matching and conversion gain of the front-end receiver are improved. Index Terms—Heterogeneous integration, packaging, system- on-chip (SOC), system-on-package (SIP), wafer-scale integration.
Conditional Association (2012)

Estimating conditional dependence between two random variables given the knowledge of a third random variable is essential in neuroscientific applications to understand the causal architecture of a distributed network. However, existing methods of assessing conditional dependence, such as the conditional mutual information, are computationally expensive, involve free parameters, and are difficult to understand in the context of realizations. In this letter, we discuss a novel approach to this problem and develop a computationally simple and parameter-free estimator. The difference between the proposed approach and the existing ones is that the former expresses conditional dependence in terms of a finite set of realizations, whereas the latter use random variables, which are not available in practice. We call this approach conditional association, since it is based on a generalization of the concept of association to arbitrary metric spaces. We also discuss a novel and computationally efficient approach of generating surrogate data for evaluating the significance of the acquired association value.
Down-regulation of dendritic spine and glutamic acid decarboxylase 67 expressions in the reelin haploinsufficient heterozygous reeler mouse (2001)

Heterozygous reeler mice (HRM) haploinsufficient for reelin express approximately 50% of the brain reelin content of wild-type mice, but are phenotypically different from both wild-type mice and homozygous reeler mice. They exhibit, (i) a down-regulation of glutamic acid decarboxylase 67 (GAD(67))-positive neurons in some but not every cortical layer of frontoparietal cortex (FPC), (ii) an increase of neuronal packing density and a decrease of cortical thickness because of neuropil hypoplasia, (iii) a decrease of dendritic spine expression density on basal and apical dendritic branches of motor FPC layer III pyramidal neurons, and (iv) a similar decrease in dendritic spines expressed on the basal dendrite branches of CA1 pyramidal neurons of the hippocampus. To establish whether the defect of GAD(67) down-regulation observed in HRM is responsible for neuropil hypoplasia and decreased dendritic spine density, we studied heterozygous GAD(67) knockout mice (HG(67)M). These mice exhibited a down-regulation of GAD(67) mRNA expression in FPC (about 50%), but they expressed normal amounts of reelin and had no neuropil hypoplasia or down-regulation of dendritic spine expression. These findings, coupled with electron-microscopic observations that reelin colocalizes with integrin receptors on dendritic spines, suggest that reelin may be a factor in the dynamic expression of cortical dendritic spines perhaps by promoting integrin receptor clustering. These findings are interesting because the brain neurochemical and neuroanatomical phenotypic traits exhibited by the HRM are in several ways similar to those found in postmortem brains of psychotic patients.
Worst-Case Analysis of Greedy Heuristics for Integer Programming with Nonnegative Data (1982)

We give a worst-case analysis for two greedy heuristics for the integer programming problem minimize cx, Ax ≥ b, 0 ≤ x ≤ u, x integer, where the entries in A, b, and c are all nonnegative. The first heuristic is for the case where the entries in A and b are integral, the second only assumes the rows are scaled so that the smallest nonzero entry is at least 1. In both cases we compare the ratio of the value of the greedy solution to that of the integer optimal. The error bound grows logarithmically in the maximum column sum of A for both heuristics.
On Winners and Losers in Procurement Auctions (2014)

The use of auctions in procurement results in price reduction as well as the reduction in the cost and the time required to complete transactions. In many situations, priceonly auctions resulted in the violation of the contracts or even contractors' bankruptcies. This
Theoretical and experimental stability maps of optically injected semiconductor laser (2001)

We found very good agreement between theoretical and experimental bifurcation diagrams of an optically injected diode laser. Identifying regions of various dynamics opens new possibilities for applying this system to all optical signal manipulation.
On the dimensionality of optical absorption, gain, and recombination in quantum-confined structures (2000)

The purpose of this paper is to explore the dimensionality of the optoelectronic properties of quantum-well and dot systems by expressing carrier distributions in the confinement directions in terms of envelope functions rather than assuming that carriers are localized to the geometrical extent of the confining potential. The conclusions apply to an ideal two-dimensional (2-D) system or a structure where only the n=1 electron and hole subbands are populated. We show that optical absorption normal to the plane of a QW cannot be expressed as an absorption coefficient but should be specified as a fraction of light transmitted or absorbed per well. The modal gain for light propagating along the plane of a QW does not scale with well width and the variation of the material gain inversely proportional to the well width is a consequence of the definition of the confinement factor and has no independent physical significance. Coupling to the optical mode can be specified as a mode width without the need to assume the gain medium is localized in the well. Optical absorption and gain by quantum dots should be expressed as a cross section per dot. The radiative recombination current should be expressed in terms of a two-dimensional recombination coefficient and use of an equivalent three-dimensional coefficient introduces an artificial dependence on well width which can lead to errors in the comparison of QW systems. We provide an analysis of experimental data for optical absorption in GaAs wells and show that, using the correct dimensional forms, it is straightforward to use this to estimate modal gain and the recombination coefficient.
Perfluorodioxolane Polymers for Gas Separation Membrane Applications (2020)

Since the discovery of polytetrafluoroethylene (PTFE) in 1938, fluorinated polymers have drawn attention in the chemical and pharmaceutical field, as well as in optical and microelectronics applications. The reasons for this attention are their high thermal and oxidative stability, excellent chemical resistance, superior electrical insulating ability, and optical transmission properties. Despite their unprecedented combination of desirable attributes, PTFE and copolymers of tetrafluoroethylene (TFE) with hexafluoropropylene and perfluoropropylvinylether are crystalline and exhibit poor solubility in solvents, which makes their processability very challenging. Since the 1980s, several classes of solvent-soluble amorphous perfluorinated polymers showing even better optical and gas transport properties were developed and commercialized. Amorphous perfluoropolymers exhibit, however, moderate selectivity in gas and liquid separations. Recently, we have synthesized various new perfluorodioxolane polymers which are amorphous, soluble, chemically and thermally stable, while exhibiting much enhanced selectivity. In this article, we review state-of-the-art and recent progress in these perfluorodioxolane polymers for gas separation membrane applications.
Corrected splicing of a chicken ovalbumin gene transcript in mouse L cells. (1980)

Mouse thymidine-kinase-negative L cells were transformed with a cloned chicken ovalbumin gene linked to the cloned thymidine kinase gene from herpes simplex virus type 1. Most thymidine-kinase-positive clones contained one or more copies of the ovalbumin gene, which were stably maintained for at least 6 months during continuous culture under selective conditions. Transcription of the ovalbumin gene was detected at a low level, producing RNA molecules that were correctly spliced and polyadenylylated by comparison with genuine ovalbumin mRNA. However, the 5' end of these RNA molecules does not correspond to that of ovalbumin mRNA.