gebhart/patrepeval huggingface dataset:
Expression and localization of endothelin-1 and endothelin receptors in human meningiomas. Evidence for a role in tumoral growth. (1995)

In addition to its well-known homoeostatic actions in the cardiovascular system, ET-1 has been shown to constitute a potent growth regulatory peptide in various tissues. We have studied the expression of ET-1 and its receptors (ET-Ar and ET-Br) in human meningiomas (n = 35) as well as their involvement in cellular growth. By PCR of reverse-transcribed RNA we detected ET-1 mRNA in 91% (32 of 35), ET-Ar mRNA in 82% (29 of 35), and ET-Br mRNA in 42% (15 of 35) of human meningiomas examined. The localization of ET-1 mRNA, ET-Ar mRNA, and ET-1 peptide in tumoral cells was observed by in situ hybridization and immunohistochemistry, whereas ET-Br mRNA was expressed at low level only in cells belonging to blood vessels. In addition, we found that ET-1 stimulated [3H] thymidine incorporation in primary cell cultures of 20 meningiomas and that this effect could be blocked by BQ-123, a specific antagonist for ET-Ar. In contrast, RES-701-3, an antagonist of ET-Br, did not block the proliferative effect of ET-1. In conclusion, our data provide evidence that ET-1 constitutes an important growth factor for meningiomas acting via ET-Ar. We can hypothesize that ET-1, acting in concert with other growth factors and cytokines, is involved in the meningioma tumorigenesis.
Kinetics of nickel-induced lateral crystallization of amorphous silicon thin-film transistors by rapid thermal and furnace anneals (1999)

The activation energy for nickel-induced lateral crystallization of amorphous silicon heated in an inert atmosphere was investigated, and was found to be 1.75 eV for rapid thermal annealing and 1.86 eV for furnace annealing. Polycrystalline silicon thin-film transistors fabricated in furnace recrystallized and rapid thermal recrystallized material had similar device characteristics, even though the crystallization velocity differed by a factor of 3.
Hyperspectral Computational Imaging via Collaborative Tucker3 Tensor Decomposition (2020)

Computational imaging for hyperspectral images (HSIs) is a hot topic in remote sensing and imaging systems. The dual-camera compressive hyperspectral imaging (DCCHI) system has been successfully designed and applied in hyperspectral imaging. However, the corresponding reconstruction algorithms are not well developed. In this paper, under the DCCHI framework, a new reconstruction algorithm is proposed based on the collaborative Tucker3 Tensor decomposition. In actual HSI, similar nonlocal patches always have similar spatial-spectral structures, and thus, these nonlocal patches can share the same spatial and spectral factors in Tucker decomposition. To characterize the similarities simultaneously, the Tucker3 decomposition is used to model the 4-order tensor formed by the similar cubic patches. To keep the spatial structures in the reconstructed HSI consistent with the panchromatic image's spatial structures, we force the spatial factor matrices and the core tensor in the Tucker3 decomposition of the HSI to be identical to the spatial factor matrices and core tensor of the panchromatic image's Tucker3 decomposition. In addition, a spectral quadratic variation constraint is introduced into the spectral factor to characterize the band smoothness. To solve the optimization problem, an alternating direction method of multipliers (ADMM)-based algorithm is designed and each variable is separately solved. Experimental results on a public data set and the remote sensing image demonstrate the advantage of the proposed method.
Bio equivalence Study of Atorvastatin Tablets (2011)

The study was designed to evaluate the relative bioavailability of two formulations of atorvastatin (CAS 134523-03-8). A bioequivalence study was carried out in 24 healthy male volunteers who received four 10 mg tablets of the test formulation (Kolestor) and the same dose of the originator product. The trial was performed according to an open, crossover design with a wash-out period of 7 days in one study center. Blood samples were taken up to 48 h post dose, the plasma was separated and the concentrations of atorvastatin were determined by HPLC-MS-MS method. The mean Cmax were 16.37 ng/mL and 17.05 ng/mL, while the mean AUC0-t were 103.61 ng x h/mL and 102.55 ng x h/mL for the test and reference formulations, respectively. The mean AUC0-inf were 118.10 ng x h/mL and 117.13 ng x h/mL for the test and reference formulations, respectively. The median tmax was 0.67 h for both the test tablet and the reference product. The mean t(1/2 el) was 11.85 h for the test formulation and 13.28 h for the reference formulation. No significant differences of pharmacokinetic parameters between the two studied formulations were found. The 90% confidence intervals for the primary target parameters, intra-individual ratios of AUC0-t and Cmax of atorvastatin, were between 0.85 and 1.05 (AUC0-t) and between 0.84 and 1.23 (Cmax), respectively, and thus within the acceptance ranges. Concerning the secondary parameter tmax the 90% confidence interval for the intra-individual differences was between -0.17 and 0.17 h. In the light of the present study it can be concluded that the two evaluated atorvastatin formulations, i.e. test formulation of atorvastatin and reference preparation are bioequivalent in terms of the rate and extent of absorption.
PIKA adjuvant induces the immune responses in mouse in vitro and in vivo (2006)

To evaluate immune responses of mouse induced by PIKA adjuvant both in vitro and in vivo. Mouse splenocytes were prepared and cultured with different concentrations of PIKA adjuvant.The production of IFN-gamma and IL-12p40 was determined by ELISA,and cell activation and proliferation was evaluated in vitro by FACS. For in vivo studies, mouse was injected(i.p.) with PIKA adjuvant and cytokines such as IFN-gamma, IL-12p40, IL-6, TNF-alpha in serum were assayed by ELISA at different time points after injection. PIKA adjuvant induced production of IFN-gamma and IL-12p40 by mouse splenocytes in a dose-dependent manner in vitro. Cellular analysis demonstrated that PIKA elicited the activation and proliferation of B cells and NK cells but not CD4~(+) and CD8~(+) T cells. Following injection, PIKA adjuvant induced the production of IFN-gamma, IL-12p40, IL-6, TNF-alpha in vivo with different kinetics. PIKA adjuvantmay directly enhance immune responses via the induction of cytokine secretion, activation and proliferation of B and NK cells.
Pooling-analysis for diagnostic and prognostic value of MiRNA-100 in various cancers (2017)

Many studies manifested miRNA-100 was deregulated in various cancers, which indicated that miRNA-100 might be a potential biomarker of cancer diagnosis and prognosis. However, the role of miRNA-100 was still uncertain. We searched for qualified studies using PubMed, EMBASE, Web of Science, Cochrane library and CNKI databases. The diagnostic effect was evaluated by the pooled sensitivity, specificity, and other indexes. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) for overall survival (OS) were calculated to assess the prognostic value. This meta-analysis included 7 and 19 studies about diagnosis and prognosis, respectively. The results of pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR) and diagnostic odds ratio (DOR) were 0.75 (95%CI: 0.71-0.78), 0.74 (95%CI: 0.69-0.78), 2.61 (95%CI: 1.81-3.76), 0.33 (95%CI: 0.24-0.45), 8.46 (95%CI: 4.85-14.77), respectively. And, the area under SROC curve (AUC) was 0.8141. We also found that lower expression of miRNA-100 in cancer tissues could significantly predict poorer prognosis in overall cancer (HR = 0.59, 95%CI: 0.39-0.90), especially in genital system tumors (HR = 0.42, 95%CI: 0.27-0.66, P = 0.431), bladder cancer (HR = 0.21, 95%CI: 0.06-0.73, P = 0.143) and esophageal squamous cell carcinoma (HR = 0.26, 95%CI: 0.13-0.52, P = 0.164). Our studies concluded that miRNA-100 has a certain value in diagnosis and it may indicate a poor prognosis of cancers.
Determination of extended substrate specificity of the MALT1 as a strategy for the design of potent substrates and activity-based probes (2018)

Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) belongs to the CD clan of cysteine proteases. MALT1 is a unique enzyme among this clan because it recognizes the basic amino acid arginine in the P1 pocket. Previous studies carried out with natural amino acids revealed the substrate specificity of the P4-P1 pockets of MALT1 but have provided only limited information about the catalytic preferences of this enzyme. In this study, we exploited Hybrid Combinatorial Substrate Library and Internally Quenched Fluorescence substrate technologies to interrogate the extended substrate specificity profile of the S5-S2' active site pockets using unnatural amino acids. This strategy resulted in the design of a peptide-based fluorogenic substrate, which exhibited significant activity toward MALT1. Subsequently, the substrate sequence was further utilized to develop potent, irreversible activity-based probes.
Spontaneous Lead Breakage in Implanted Spinal Cord Stimulation Systems (2010)

Spinal cord stimulation (SCS) has become an established clinical option for treatment of refractory chronic pain. Current hardware and implantation techniques for SCS are already highly developed and continuously improving; however, equipment failures over the course of long-term treatment are still encountered in a relatively high proportion of the cases treated with it. Percutaneous SCS leads seem to be particularly prone to dislocation and insulation failures. We describe our experience of lead breakage in the inserted spinal cord stimulator to a complex regional pain syndrome patient who obtained satisfactory pain relief after the revision of SCS.
Screen printed chipless RFID tags on packaging substrates (2021)

Abstract A chipless radio frequency identification (RFID) tag is a suitable low-cost alternative to any chip-based RFID one. The flexibility to use low-cost printing techniques makes chipless RFID a competitive technology. In this paper, we report an evaluation of the microwave performance of two different screen-printed chipless tags in the 3–6 GHz range. The tags were designed and screen printed on industry packaging laminates using nanoparticle conductive ink-paste supplied by ANP and InkTec companies. The measured microwave performance of tags was compared with simulated performance and printing parameters that influence the print quality, and eventually, the microwave response of the tags are discussed.
A New Apparatus for Chronic Observation of the Microcirculation In Situ to Evaluate Artificial Organ Performance (1994)

Chronic study of the peripheral circulation and metabolism is very important in evaluation of artificial organ performance. However, there has been no way to observe the microcirculation in situ, chronically and continuously, without restriction. In this study, the authors developed a new apparatus that could be implanted and connected to an artificial organ that would allow continuous observation of the microcirculation while the subject is awake. The apparatus uses a charge coupled device (CCD) under a new principle: thin living tissue, such as mesentery, is put directly on a highly integrated CCD and transilluminated with a light emitting diode (LED). The vascular nets in the tissue are projected onto the CCD like a contact photograph, which is sent to a television screen and can be analyzed for motion and function. A 0.5 inch CCD with 25K pixels was used in this study. The cover glass of the CCD was removed so the tissue would be able to directly contact the CCD surface. The CCD, as well as LED, were molded with hard polyurethane as electrical insulation. The apparatus is 35 mm in diameter and 10 mm high with a micro stand for lighting with the LED, which is easy to implant in a goat or calf. The resolution of this apparatus was tested by putting a micro scale on the CCD surface. Several tenths of micrometers could be seen. In an animal experiment with a rabbit, configurations of arterioles and venules and their motions could be observed continuously for a night until the electrical insulation was broken. This method might be a strong weapon in artificial organs research.
Optimization of contact grids for solar cells with genetic algorithms (2017)

The purpose of this paper is to use genetic algorithm to optimize the solar cell comb shaped grids, so as to minimize the total grid related losses, namely: series resistance and shadowing losses. Minimizing such losses should lead to improved solar cell efficiencies. We have varied the height, width and number of fingers of the grids within the genetic algorithm in order to find the optimal parameters. More than 5% reduction in losses was predicted with the optimized grid dimensions.
A continuous gravity profile over the Sigsbee Knolls (1966)

Introduction. Several knolls discovered in 1953 during Vema cruise 3 [Ewing, Ericson, and Heezen, 1958] rising to a few hundred meters above the Sigsbee abyssal plain in the Gulf of Mexico were investigated by continuous seismic reflection in 1961 during Vema cruise 17 [Ewing, Worzel, and Ewing 1962] and found to be accompanied by a large number of buried structures. The entire group was judged to be a field of diapirs, called the Sigsbee knolls and domes, resulting from inversion of density in a thick accumulation of (largely) turbidite sediments covering the oceanic crust of the basin floor. It was reported that no large gravity or magnetic anomalies were associated with these features.
Introduction to Cavity-Ringdown Spectroscopy (1999)

Cavity-ringdown spectroscopy is an alternative way of measuring small fractional absorptions down to sub-ppm levels per pass in the cavity. In this chapter, the basic principles behind cavity-ringdown spectroscopy are discussed. The areas where ultra-sensitive absorption measurements in the gas phase are important are illustrated, and existing methods of making these measurements are presented. The experimental requirements for performing cavity-ringdown spectroscopy are discussed, and an expression for the detection limit in cavity-ringdown spectroscopy is derived from statistical considerations. Finally, future prospects for the technique are discussed.
Lack of Multidrug Resistance-associated Protein 4 Prolongs Partial Hepatectomy-induced Hepatic Steatosis (2020)

Multidrug resistance-associated protein 4 (Mrp4) is an efflux transporter involved in the active transport of several endogenous and exogenous chemicals. Previously, we have shown that hepatic Mrp4 expression increases following acetaminophen overdose. In mice, these increases in Mrp4 expression are observed specifically in hepatocytes undergoing active proliferation. From this, we hypothesized that Mrp4 plays a key role in hepatocyte proliferation and that lack of Mrp4 impedes liver regeneration following liver injury and/or tissue loss. To evaluate the role of Mrp4 in these processes, we employed two-third partial hepatectomy (PH) as an experimental liver regeneration model. In this study, we performed PH-surgery on male wildtype (C57BL/6J) and Mrp4 knockout mice. Plasma and liver tissues were collected at 24, 48, and 72 h postsurgery and evaluated for liver injury and liver regeneration endpoints, and for PH-induced hepatic lipid accumulation. Our results show that lack of Mrp4 did not alter hepatocyte proliferation and liver injury following PH as evaluated by Ki-67 antigen staining and plasma alanine aminotransferase levels. To our surprise, Mrp4 knockout mice exhibited increased hepatic lipid content, in particular, di- and triglyceride levels. Gene expression analysis showed that lack of Mrp4 upregulated hepatic lipin1 and diacylglycerol O-acyltransferase 1 and 2 gene expression, which are involved in the synthesis of di- and triglycerides. Our observations indicate that lack of Mrp4 prolonged PH-induced hepatic steatosis in mice and suggest that Mrp4 may be a novel genetic factor in the development of hepatic steatosis.
Psychological responses to natural patterns in architecture (2018)

Exposure to natural environments, compared to built spaces, has been shown to confer important psychological benefits. Furthermore, people generally exhibit preferences for natural landscapes over man-made buildings. However, some forms of architectural design draw inspiration from natural systems and thus exhibit similar sensory qualities as nature itself. Can these natural features be measured, and are buildings which exhibit these features inherently preferred? Here, we examined whether subjective perceptions of naturalness in architectural scenes are driven by objective visual patterns, and we investigated whether natural patterns influence similarity evaluations and preference ratings of architectural scenes. Experiment 1 revealed that low-level spatial and color features of architectural scenes explained over half of the variance in scene naturalness ratings. Scaling and Contrast-related features were especially strong predictors of naturalness for both interior and exterior scenes. In Experiment 2, participants completed an image arrangement task and multidimensional scaling (MDS) analysis was performed on the data to determine the underlying aesthetic dimensions that drove scene similarity judgements. Naturalness ratings explained over half of the variance in MDS Dimension 1 weights, suggesting that people relied on latent perceptions of naturalness to evaluate the similarity of architectural scenes. In the final experiment, participants rated architectural scenes on aesthetic preference. Nature-like patterns of Scaling and Contrast significantly predicted preference ratings. Furthermore, the effects of Scaling and Contrast on preference were mediated by latent perceptions of naturalness, indicating that these architectural patterns are preferred because they evoke intuitive associations with sensory features of nature. Collectively, these studies suggest that people may be innately attuned to naturalistic features of the built environment, and that these features can be measured using computational methods of image analysis.
Readily Accessible, Modular, and Tuneable BINOL 3,3‘-Perfluoroalkylsulfones:  Highly Efficient Catalysts for Enantioselective In-Mediated Imine Allylation (2007)

Thia−Fries rearrangement of BINOL perfluoroalkylsulfonates affords readily derivatized novel mono- and disulfone ligands in just two steps from enantiomerically pure BINOL. These electron-demanding BINOLs have been successfully applied as catalysts for indium-mediated allylation of N-acylhydrazones. A general and highly enantioselective catalytic process is described, in which the presence of two perfluoroalkylsulfone (SO2RF) groups is shown to be crucial for activity and selectivity. The allylation process affords the corresponding homoallylic amines up to 99% yield and 99% ee.
The effect of hot electron stress on the DC and microwave characteristics of AlGaAs/InGaAs/GaAs PHEMTs (2005)

This work reports on hot electron reliability of 0.25 /spl mu/m Al/sub 0.25-/ Ga/sub 0.75/As/In/sub 0.2/Ga/sub 0.8/As/GaAs PHEMTs from the viewpoint of both DC and RF characteristics. The changes of DC and RF behavior after high drain bias stressing are shown to be strongly correlated. Both can be attributed to a decrease of the threshold voltage, yielding different effects on gain depending on the bias point and circuitry chosen for device operation: a fixed current bias scheme is shown to minimize the changes induced by the stress.
Ultra-Low-Latency, High-Fidelity Analog-to-Digital-Compression Radio-Over-Fiber (ADX-RoF) for MIMO Fronthaul in 5G and Beyond (2020)

Wired-wireless convergence technology such as radio-over-fiber (RoF) is regarded as a promising candidate to deliver broadband wireless data from/to edge cloud to/from antenna sites, a notable example being the fronthaul (FH) in centralized/cloud radio access network (C-RAN). In 5G and beyond, the latency, bandwidth and fidelity requirements on FH pose great challenges to the RoF schemes. In this article, we focus on analog-to-digital-compression RoF (ADX-RoF) scheme based on low-latency MIMO data compression, which has the potential to reduce FH data rate by ~90% compared with traditional digital RoF (CPRI) while still maintaining signal fidelity for high-order radio modulation. To verify the practicality of ADX-RoF in the latency-sensitive FH scenario, real-time hardware demonstration with latency evaluation is indispensable. We propose and design a real-time ADX, which achieves low-latency and high-throughput together with high-fidelity. Enabled by the ADX prototyped on a single-chip field-programmable radio platform (i.e., Xilinx RFSoC), we experimentally demonstrate 16-channel MIMO radio reception, real-time ADX processing and RoF transport. With <; 500 ns one-way ADX latency, less than 1.5% average EVM is achieved for 1024QAM, 61.44 MHz NR-class signals at a compression ratio of 13.3%. Negligible fiber-induced performance penalty is observed after 40 km transport. The results highlight the attractiveness of ADX-RoF for future FH.
Automated Brewing Process (2013)

There are few automated gas control systems that incorporate anything more&#13;\nthan proportional control. This thesis will look at the process of making beer at home with a three kettle setup, the possible parts that would need to be incorporated in the system to allow proportional integral derivative control, and how the control theory may work. The research required will look into the basics of control laws. A design hurdle that will need to be met is a control valve that is within the weekend home brewers price&#13;\nrange. With a truly robust control system, a home brewer would save money and time. The final conclusion that was approached is that there is room for the product, but the product is not currently producible.
A Subquadratic Sequence Alignment Algorithm for Unrestricted Scoring Matrices (2003)

Given two strings of size n over a constant alphabet, the classical algorithm for computing the similarity between two sequences [D. Sankoff and J. B. Kruskal, eds., {Time Warps, String Edits, and Macromolecules}; Addison-Wesley, Reading, MA, 1983; T. F. Smith and M. S. Waterman, { J.\ Molec.\ Biol., 147 (1981), pp. 195-197] uses a dynamic programming matrix and compares the two strings in O(n2 ) time. We address the challenge of computing the similarity of two strings in subquadratic time for metrics which use a scoring matrix of unrestricted weights. Our algorithm applies to both {local} and {global} similarity computations. The speed-up is achieved by dividing the dynamic programming matrix into variable sized blocks, as induced by Lempel-Ziv parsing of both strings, and utilizing the inherent periodic nature of both strings. This leads to an $O(n^2 / \log n)$, algorithm for an input of constant alphabet size. For most texts, the time complexity is actually $O(h n^2 / \log n)$, where $h \le 1$ is the entropy of the text. We also present an algorithm for comparing two {run-length} encoded strings of length m and n, compressed into m' and n' runs, respectively, in O(m'n + n'm) complexity. This result extends to all distance or similarity scoring schemes that use an additive gap penalty.
Synergistic Effects of Oncolytic Reovirus and Cisplatin Chemotherapy in Murine Malignant Melanoma (2009)

The combination of reovirus and several chemotherapeutic agents synergistically enhanced cytotoxicity in human and murine melanoma cell lines in vitro and murine tumors in vivo. The data support the current reovirus/chemotherapy combination phase I clinical studies currently ongoing in the clinic.
Population differences in platinum toxicity as a means to identify novel genetic susceptibility variants (2010)

Enriched 'platinum susceptible' populations can be used to discover novel genetic determinants governing interindividual platinum chemotherapy susceptibility.