gebhart/patrepeval huggingface dataset:
Exploring temporal effects for location recommendation on location-based social networks (2013)

Location-based social networks (LBSNs) have attracted an inordinate number of users and greatly enriched the urban experience in recent years. The availability of spatial, temporal and social information in online LBSNs offers an unprecedented opportunity to study various aspects of human behavior, and enable a variety of location-based services such as location recommendation. Previous work studied spatial and social influences on location recommendation in LBSNs. Due to the strong correlations between a user's check-in time and the corresponding check-in location, recommender systems designed for location recommendation inevitably need to consider temporal effects. In this paper, we introduce a novel location recommendation framework, based on the temporal properties of user movement observed from a real-world LBSN dataset. The experimental results exhibit the significance of temporal patterns in explaining user behavior, and demonstrate their power to improve location recommendation performance.
P2‐301: Reduced brain β‐amyloid burden, associated microglia inflammation and spatial memory deficit in hAPP transgenic mice treated for six months with CHF5074, a novel gamma‐secretase modulator (2008)

Gamma-secretase is responsible for the intramembraneous cleavage of the amyloid precursor protein (APP), the Notch receptor, and several other substrates. While inhibition of gamma-secretase results in potentially therapeutic reductions in the neurotoxic Aβ peptide, severe side effects might result from inhibiting Notch processing. CHF5074 is a new functional gamma-secretase modulator, devoid of Notch-interfering activities in vitro and in vivo. We evaluated the effects of long-term treatment with CHF5074 on brain Aβ pathology in transgenic mice (hAPP) expressing the Swedish and London mutations of human APP. Sixty 6-month old hAPP mice were treated for 6 months with CHF5074 (375 ppm in the diet), ibuprofen (375 ppm in the diet) or standard diet. Twenty-one age-matched wild type mice received standard diet for 6 months. Plaque load in cortex and hippocampus was evaluated using 6E10 antibodies. Microglia was estimated using monoclonal CD11b antibodies. Spatial memory was assessed with the Morris water maze (MWM). Compared to transgenic controls, CHF5074 treatment significantly reduced the area occupied by plaques in cortex (-34.3±6.1%, p=0.039) and hippocampus (-44.5±4.9%, p=0.002). Number of plaques were also significantly reduced by CHF5074 (-32.2±4.8%, p=0.022 and -39.8±4.9%, p=0.003, in cortex and hippocampus, respectively). Plaque-associated microglia in CHF5074-treated animals was significantly lower than in transgenic controls (-42.1±5.4% and -44.6±8.3% in cortex and hippocampus, respectively). Ibuprofen significantly reduced microglia area in cortex and hippocampus (-40.6±7.9% and -37.7±5.2%, respectively) but not β-amyloid burden (-18.2±10.6%, and -25.2±10.1%, respectively). On Day 4 of the MWM test, transgenic controls performed significantly worse the non-transgenic animals on both the escape latency (28.0±4.3 vs 17.0±2.8 sec, p=0.017) and distance moved (3.26±0.57 vs 1.95±0.34 meters, p=0.007). Transgenic animals of the CHF5074-treated group performed significantly better than transgenic controls on the distance moved (2.12±0.33 meters, p=0.025). Ibuprofen-treated animals did not perform significantly better than transgenic controls. Long-term treatment with CHF5074 was well tolerated as mortality and body weight gain did not differ from transgenic controls. Chronic CHF5074 treatment significantly reduced brain β-amyloid burden and associated microglia inflammation and attenuated spatial memory deficit in hAPP mice. This novel gamma-secretase modulator has the potential to be an effective and safe therapeutic agent for AD.
A survey on table tolerances and couch overrides in radiotherapy (2016)

The purpose of this study was to survey current departmental policies on treatment couch overrides and the values of table tolerances used clinically. A 25-question electronic survey on couch overrides and tolerances was sent to full members of the American Association of Physicists in Medicine (AAPM). The first part of the survey asked participants if table overrides were allowed at their institution, who was allowed to perform these overrides, and if imaging was required with overrides. The second part of the survey asked individuals to provide table tolerance data for the following treatment sites: brain/head and neck (H&N), lung, breast, abdo-men/pelvis and prostate. Each site was further divided into IMRT/VMAT and 3D conformal techniques. Spaces for free-text were provided, allowing respondents to enter any table tolerance data they were unable to specify under the treatment sites listed. A total of 361 individuals responded, of which approximately half partici-pated in the couch tolerances portion of the survey. Overall, 86% of respondents' institutions allow couch tolerance overrides at treatment. Therapists were the most common staff members permitted to perform overrides, followed by physicists, dosimetrists, and physicians, respectively. Of the institutions allowing overrides, 34% reported overriding daily. More than half of the centers document the over-ride and/or require a setup image to radiographically verify the treatment site. With respect to table tolerances, SRS/SBRT table tolerances were the tightest, while clinical setup table tolerances were the largest. There were minimal statistically significant differences between IMRT/VMAT and 3D conformal table tolerances. Our results demonstrated that table overrides are relatively common in radiotherapy despite being a potential safety concern. Institutions should review their override policy and table tolerance values in light of the practices of other institutions. Careful attention to these matters is crucial in ensuring the safe and accurate delivery of radiotherapy.
Cellular-automata calculation of frequency-dependent permeability of porous media (1993)

We use a cellular-automata (CA) method to determine the frequency-dependent permeability k(\ensuremath{\omega}) of a channel and a disordered porous medium. The CA results for the channel flow agree completely with the analytical solution of the problem. For flow in a porous medium, we calculate k(\ensuremath{\omega}) over a wide range of the frequencies \ensuremath{\omega} and for several values of the porosity. Our CA results for disordered porous media support the relation k(\ensuremath{\omega})/${\mathit{k}}_{0}$=f(\ensuremath{\omega}/${\mathrm{\ensuremath{\omega}}}_{\mathit{c}}$), where ${\mathit{k}}_{0}$ is the static permeability of the medium, ${\mathrm{\ensuremath{\omega}}}_{\mathit{c}}$ is a characteristic frequency, and f(x) is a universal function, proposed previously, based on experimental data.
Deep Learning Based Prediction Model for Easterly Wind (2019)

Understanding the characteristics of the easterly-related weather phenomena in the eastern coast in Korean Peninsula is very important to analyze abnormal atmospheric phenomena such as heavy rain, heavy snow, and hot-dry wind. As data science techniques have steadily improved, data driven prediction models are becoming more powerful in the quantitative forecasting weather. In this paper, we apply the deep learning based methods to predict the presence or absence of the easterly wind around the Korean peninsula. The DNN, CNN, and LSTM based deep learning approaches for prediction of easterly wind are experimented and compared for the Korean Peninsula and East Sea. Vertical pressure levels of ERA5 data in year 2013 and 2014 are used.
The DNA double-stranded break repair protein endo-exonuclease as a therapeutic target for cancer (2004)

DNA repair mechanisms are crucial for the maintenance of genomic stability and are emerging as potential therapeutic targets for cancer. In this study, we report that the endo-exonuclease, a protein involved in the recombination repair process of the DNA double-stranded break pathway, is overexpressed in a variety of cancer cells and could represent an effective target for developing anticancer drugs. We identify a dicationic diarylfuran, pentamidine, which has been used clinically to treat opportunistic infections and is an inhibitor of the endo-exonuclease as determined by enzyme kinetic assay. In clonogenic and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays as well as in the in vivo Lewis lung carcinoma mouse tumor model, pentamidine is shown to possess the ability to selectively kill cancer cells. The LD50 of pentamidine on cancer cells maintained in vitro is correlated with the endo-exonuclease enzyme activity. Tumor cell that has been treated with pentamidine is reduced in the endo-exonuclease as compared with the untreated control. Furthermore, pentamidine synergistically potentiates the cytotoxic effect of DNA strand break and cross-link-inducing agents such as mitomycin C, etoposide, and cisplatin. In addition, we used the small interfering RNA for the mouse homologue of the endo-exonuclease to down-regulate the level of endo-exonuclease in the mouse myeloma cell line B16F10. Down-regulation of the endo-exonuclease sensitizes the cell to 5-fluorouracil. These studies suggested the endo-exonuclease enzyme as a novel potential therapeutic target for cancer.
A century of controversy surrounding posttraumatic stress-spectrum syndromes: The impact on DSM-III and DSM-IV (1996)

The authors describe historical clinical reports that preceded the development of criteria for posttraumatic stress disorder (PTSD) and influenced the formation of PTSD in DSM-IV. These reports were identified from extensive search of 19th- and 20th-century American and European medical literature. Relevant findings from the most representative reports are described and discussed. Since the mid-19th century, clinical syndromes resembling PTSD have been described. However, understanding of PTSD has been complicated by questions of nomenclature, etiology, and compensation. Nomenclature placed PTSD syndromes under existing psychiatric disorders: traumatic hysteria, traumatic neurasthenia, or traumatic neurosis. Etiological issues have been concerned often solely with organic factors, pre-existing personality impairments, intrapsychiatric conflicts, and social factors. Only after World War II and the concentration camp experiences did the role of severe trauma in PTSD become recognized. Even though controversy remains, much progress in understanding PTSD has been made.
Structure-activity relationships in the hydrolysis of substrates by the phosphotriesterase from Pseudomonas diminuta (1989)

The mechanism and substrate specificity of the phosphotriesterase from Pseudomonas diminuta have been examined. The enzyme hydrolyzes a large number of phosphotriester substrates in addition to paraoxon (diethyl p-nitrophenyl phosphate) and its thiophosphate analogue, parathion. The two ethyl groups in paraoxon can be changed to propyl and butyl groups, but the maximal velocity and Km values decrease substantially. The enzyme will not hydrolyze phosphomonoesters or -diesters. There is a linear correlation between enzymatic activity and the pKa of the phenolic leaving group for 16 paraoxon analogues. The beta value in the corresponding Brønsted plot is -0.8. No effect on either Vmax or Vmax/Km is observed when sucrose is used to increase the relative solvent viscosity by 3-fold. These results are consistent with rate-limiting phosphorus-oxygen bond cleavage. A plot of log V versus pH for the hydrolysis of paraoxon shows one enzymatic group that must be unprotonated for activity with a pKa of 6.1. The deuterium isotope effect by D2O on Vmax and Vmax/Km is 2.4 and 1.2, respectively, and the proton inventory is linear, which indicates that only one proton is "in flight" during the transition state. The inhibition patterns by the products are consistent with a random kinetic mechanism.
Differential transcriptomic responses to Fusarium graminearum infection in two barley quantitative trait loci associated with Fusarium head blight resistance (2016)

The current transcriptomic analysis revealed differential responses conferred by two QTL during F. graminearum infection and identified genes and lncRNAs that were associated with FHB resistance.
Supplementary Table 2 from Glioma Grade Is Associated with the Accumulation and Activity of Cells Bearing M2 Monocyte Markers (2023)

&lt;p&gt;PDF - 69K, Gene-specific primers and probes for QRT-PCR.&lt;/p&gt;
Visible‐Light Sensitization of Vinyl Azides by Transition‐Metal Photocatalysis (2013)

Abstract Irradiation of vinyl and aryl azides with visible light in the presence of Ru photocatalysts results in the formation of reactive nitrenes, which can undergo a variety of CN bond‐forming reactions. The ability to use low‐energy visible light instead of UV in the photochemical activation of azides avoids competitive photodecomposition processes that have long been a significant limitation on the synthetic use of these reactions.
Detection of Choriocapillaris Loss in Alport Syndrome With Swept-Source OCT Angiography (2018)

A patient previously diagnosed with Alport Syndrome was evaluated using multimodal imaging. Optical coherence tomography (OCT) demonstrated significant thinning of the inner retina within the macula, and inner retinal cysts were found in the peripheral macula. OCT angiography demonstrated loss of the choriocapillaris. Abnormal collagen appears to have multiple deleterious effects on the retinal and choroidal structure and vasculature. [Ophthalmic Surg Lasers Imaging Retina. 2018;49:138-141.].
Indoline analogs of idazoxan: potent .alpha.2-antagonists and .alpha.1-agonists (1988)

The synthesis and alpha-adrenergic activity of a series of substituted 2-imidazolinylindolines are described. Substitution in the indoline ring generated compounds with a spectrum of adrenoceptor antagonist/agonist profiles that proved sensitive to both the nature and position of the substituent. Many of the derivatives possess greater presynaptic antagonist potency than the corresponding benzodioxan 1, dihydrobenzofuran 2, and indan 3 analogues; however, this alpha 2-antagonism is often accompanied by alpha 1-agonist activity. It was not possible to separate alpha 2-antagonist from alpha 1-agonist properties in this series. Compounds of most interest proved to be the N-ethyl 6, 5-chloro-N-methyl 18, and 5-chloro-N-ethyl 23 derivatives, all being potent alpha 2-antagonists and alpha 1-agonists. Substitution at the 4- and 7-position of the indoline ring generally gave compounds with nonselective agonist properties.
Control of Magnetic Anisotropy in (Bi 1‐x Pb x ) 2 (AE 1‐y RE y ) 2 Co 2 O z and Fabrication of Magnetically Aligned Bulks (2006)

This chapter contains sections titled: Introduction Experimental Results and Discussions Conclusions
Mutation Profiling of Key Cancer Genes in Primary Breast Cancers and Their Distant Metastases (2018)

Although the repertoire of somatic genetic alterations of primary breast cancers has been extensively catalogued, the genetic differences between primary and metastatic tumors have been less studied. In this study, we compared somatic mutations and gene copy number alterations of primary breast cancers and their matched metastases from patients with estrogen receptor (ER)-negative disease. DNA samples obtained from formalin-fixed paraffin-embedded ER-negative/HER2-positive (<i>n</i> = 9) and ER-, progesterone receptor (PR-), HER2-negative (<i>n</i> = 8) primary breast cancers and from paired brain or skin metastases and normal tissue were subjected to a hybridization capture-based massively parallel sequencing assay, targeting 341 key cancer genes. A large subset of nonsynonymous somatic mutations (45%) and gene copy number alterations (55%) was shared between the primary tumors and paired metastases. However, mutations restricted to either a given primary tumor or its metastasis, the acquisition of loss of heterozygosity of the wild-type allele, and clonal shifts of genes affected by somatic mutations, such as <i>TP53</i> and <i>RB1</i>, were observed in the progression from primary tumors to metastases. No metastasis location-specific alterations were identified, but synchronous metastases showed higher concordance with the paired primary tumor than metachronous metastases. Novel potentially targetable alterations were found in the metastases relative to their matched primary tumors. These data indicate that repertoires of somatic genetic alterations in ER-negative metastatic breast cancers may differ from those of their primary tumors, even by the presence of driver and targetable somatic genetic alterations.<b>Significance:</b> Somatic genetic alterations in ER-negative breast cancer metastases may be distinct from those of their primary tumors, suggesting that for treatment-decision making, genetic analyses of DNA obtained from the metastatic lesion rather than from the primary tumor should be considered. <i>Cancer Res; 78(12); 3112-21. ©2018 AACR</i>.
Chemoselective synthesis of long-chain alkyl-H-phosphinic acids via one-pot alkylation/oxidation of red phosphorus with alkyl-PEGs as recyclable micellar catalysts (2021)

Long-chain <i>n</i>-alkyl-<i>H</i>-phosphinic acids (Alk = C<sub>4</sub>-C<sub>18</sub>) are chemoselectively synthesized in yields up to 90% <i>via</i> the direct one-pot alkylation/oxidation of red phosphorus (P<sub><i>n</i></sub>) in the multi-phase alkyl bromide/KOH/H<sub>2</sub>O/toluene system with alkyl-PEG recyclable micellar catalysts, which demonstrate good recyclability.
Dental Silicate Cements: VI. Infrared Studies (1968)

Infrared studies have shown that silica gel and H 2 PO 4 -1 ions are formed in fresh cement paste. Subsequently, during setting and hardening, H 2 PO 4 -1 ions further react to form covalent phosphates and are removed from the system. In an uncertified cement, H 2 PO 4 -1 ions were found in substantial amounts even in the set cement, which accounted for poor strength and durability.
A Study on the Mechanics of Fatigue-Dominated Friction Noise (1990)

The generation of friction noise for fatigue-dominated interfaces is studied. A special experimental set up for studying the effects of various parameters on the generation of noise by dry friction under different running conditions of load and speed is constructed. The noise and vibration response signatures are simultaneously measured and statistically analyzed. A simplified model for the friction interface and the supporting structure is also developed, and is used to simulate the vibration and acoustic responses. It is shown that the simulation predictions are in good agreement with the experimental data. The results show that the friction noise signatures have a well defined structure with randomly occuring sharp pulses. For fatigue-dominated interfaces, the departure of the noise signature from a Gaussian process increases as acoustic radiation due to roughness interaction effects becomes more significant. The noise power spectra contain a broad frequency band with a continuous peak level extending over the high frequency range of 2–20 kHz due to the effects of impacts between surface asperities.
Mycoplasma genitalium: a common cause of persistent urethritis among men treated with doxycycline (2006)

M genitalium is a common cause of persistent or recurrent urethritis among men treated with doxycycline and erythromycin appears to be less efficient than azithromycin in eradicating the infection.
Abdominal percutaneous interventional procedures: comparison of CT and US guidance. (1998)

US guidance often allows performance of quicker, more accurate procedures than does CT guidance, probably because of its real-time capabilities.
ChemInform Abstract: Synthesis of Optically Active Arylaziridines by Regio‐ and Stereospecific Lithiation of N‐Bus‐phenylaziridine. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Structural Diversity of the Major Surface Antigen of Plasmodium falciparum Merozoites (1986)

The structures of the major merozoite surface antigen of Plasmodium falciparum and the gene encoding it were indistinguishable for the Wellcome strain and the Thai clone T9/94 but different for clones T9/96, T9/98, and T9/101. The central portion of the gene is subject to the greatest variation in structure. The protein from all five lines was found to be posttranslationally modified by covalent addition of both carbohydrate and fatty acid.
Influence of dispersion fluctuation of installed dispersion-shifted fiber on four-wave mixing induced degradation in WDM transmission system (1997)

We experimentally and theoretically investigate the allowable fiber input power for installed dispersion-shifted fiber (DSF) in a WDM transmission system. The allowable fiber input power can be obtained by numerical analyses that consider the fluctuation in the zero-dispersion wavelength of the installed DSF.
Transiently malleable multi-healable hydrogel nanocomposites based on responsive boronic acid copolymers (2018)

Dynamic multi-responsive gel nanocomposites with rapid self-healing and cell encapsulation properties are presented.
High linear 17W smart L/C-band transmitter unit for mobile communication satellite (1995)

An integrated, high efficiency, very linear high power solid state amplifier upconverter has been developed for use in a commercial mobile satellite communication system. The amplifier/upconverter provides a gain of about 65 dB and an output power in excess of 17 Watt for a multi carrier signal operation with an associated DC-to-RF efficiency greater than 21 %. The noise power ratio (NPR) for this operating point is 19 dB. The linearized amplifier/upconverter shows an improvement of about 3 dB in the output back-off compared to the non-linearized one for a given NPR of 30.0 dB. The mass of the compact transmitter unit is 1250 gram including low noise amplifier, upconverter, linearizer, SSPA and EPC.
Generation of natural killer-like activity in mixed lymphocyte-tumor cell cultures. I. Role of HLA-DR antigens as stimulatory molecules. (1985)

A number of human lymphoid and non-lymphoid leukemic cell lines differing for expression of HLA-DR antigens were analyzed for the ability to induce natural killer(NK)-like activity and proliferation in lymphocytes from healthy donors. The ability to elicit the generation of NK-like activity in the responder lymphocytes varied greatly depending upon the type of antimitotic treatment (gamma-irradiation versus mitomycin C) received by the tumor cells prior to the start of the mixed cultures. By contrast, the induction of T-cell proliferation was positively correlated with the presence of DR molecules on the tumor cell lines. Nevertheless, DR- leukemic cells pretreated with the appropriate antimitotic agent did induce a proliferative response in the mixed cultures. T lymphocytes cultured without stimulator cells in spent medium containing high levels of cell-free DR antigens failed to undergo blastogenesis and proliferation, indicating that DR antigens can function as stimulatory molecules only when they are cell-associated.