gebhart/patrepeval huggingface dataset:
Oral treatment with L-lysine and L-arginine reduces anxiety and basal cortisol levels in healthy humans (2007)

Dietary supplementation with an essential amino acid L-lysine has been shown to reduce chronic anxiety in humans with low dietary intake of L-lysine. A combination of L-lysine and L-arginine has been documented to normalize hormonal stress responses in humans with high trait anxiety. The present study was carried out in one hundred eight healthy Japanese adults. The aim of study was to find out whether a week-long oral treatment with L-lysine (2.64 g per day) and L-arginine (2.64 g per day) reduces trait and stress-induced state anxiety and basal levels of stress hormones. We confirmed that, without regard to gender, the amino acid treatment significantly reduced both trait anxiety and state anxiety induced by cognitive stress battery. In addition, we found that the treatment with L-lysine and L-arginine decreased the basal levels of salivary cortisol and chromogranin-A (a salivary marker of the sympatho-adrenal system) in male subjects. These results of this double-blind, placebo controlled and randomized study confirm the previous findings in humans and animals and point to a combination of L-lysine and L-arginine as a potentially useful dietary intervention in otherwise healthy humans with high subjective levels of mental stress and anxiety.
Induction of apoptosis in response to improved gedunin by liposomal nano-encapsulation in human non-small-cell lung cancer (NCI-H292) cell line (2017)

Purpose: To investigate the anti-proliferative activity of free and nanoencapsulated gedunin against human non-small-cell lung cancer (NCI-H292) cells.Methods: Gedunin-loaded nanoliposomes (LG) were prepared using thin-film hydration method. Antiproliferative effects of free and LD were evaluated by sulforhodamine B (SRB) assay. Apoptotic effects of gedunin-loaded liposomes were assessed by evaluating expressions of p53, Bax and survivin genes, caspase 3/7 activities, DNA fragmentation and morphological changes after staining with Hoechst 33342 and acridine orange/ethidium bromide (AO/EB).Results: Cell proliferation data and microscopic visualization demonstrated a higher anti-proliferative activity for LG than the encapsulant (liposomes) alone. LG exhibited dose- and time-dependent 10-fold anti-proliferative activity compared to the free drug, while displaying tolerable belligerence towards normal human lung fibroblast (MRC-5) cells. Apoptosis detection assays and gene expression analysis revealed the transcriptional modulation of the apoptosis-related genes (p53, survivin and Bax), increased activity of caspase 3/7 and the condensation of nuclear chromatin, implying the induction of apoptosis by the nano-formulation in NCI-H292 cells.Conclusion: LG may therefore be considered as a potential nano-formulation which can target nonsmall-cell lung cancer.Keywords: Lung cancer, Gedunin, Liposome, Nanoencapsulation, Apoptosis, Anti-proliferative activity, Nuclear chromatin
Cardioprotective Effects of Amlodipine in Animal Models of Ischemia and Reperfusion (1991)

The protective effect of amlodipine was studied in isolated blood-perfused cat hearts made globally ischemic for 60 min followed by reperfusion for 60 min. Ischemia-induced alterations of left ventricular developed pressure and compliance were monitored. Amlodipine produced significant decreases in myocardial oxygen consumption (6.2 +/- 0.4 to 4.4 +/- 0.4 ml of oxygen/min/100 g) and coronary vascular resistance, as assessed by changes in perfusion pressure (120 +/- 1 to 100 +/- 4 mm Hg). When administered before the onset of global ischemia, amlodipine decreased the development of ischemic contracture as reflected by a progressive increase in resting left ventricular diastolic pressure. The return of contractile function, 60 min after reperfusion, was improved significantly in amlodipine-treated hearts compared to controls and there was better maintenance of the tissue concentration of Na+, Ca2+, and K+. In a canine model of regional myocardial ischemia (6 h) followed by reperfusion, amlodipine at 150 microg/kg, administered 15 min before reperfusion (90 min), reduced infarct size expressed as a percentage of the area at risk (34.5 +/- 3.8% vs. 45.9 +/- 2.8%, p = 0.027). We conclude that amlodipine reduces myocardial ischemic injury by mechanism(s) that may involve a reduction in myocardial oxygen demand as well as by positively influencing transmembrane Ca2+ fluxes during ischemia and reperfusion.
On the capacity of doubly correlated MIMO channels (2006)

In this paper, we analyze the capacity of multiple-input multiple-output (MIMO) Rayleigh-fading channels in the presence of spatial fading correlation at both the transmitter and the receiver, assuming the channel is unknown at the transmitter and perfectly known at the receiver. We first derive the determinant representation for the exact characteristic function of the capacity, which is then used to determine the trace representations for the mean, variance, skewness, kurtosis, and other higher-order statistics (HOS). These results allow us to exactly evaluate two relevant information-theoretic capacity measures - ergodic capacity and outage capacity - and the HOS of the capacity for such a MIMO channel. The analytical framework presented in the paper is valid for arbitrary numbers of antennas, and generalizes the previously known results for independent and identically distributed or one-sided correlated MIMO channels to the case when fading correlation exists on both sides. We verify our analytical results by comparing them with Monte Carlo simulations for a correlation model based on realistic channel measurements as well as a classical exponential correlation model
Coronarin D, a labdane diterpene, inhibits both constitutive and inducible nuclear factor-κB pathway activation, leading to potentiation of apoptosis, inhibition of invasion, and suppression of osteoclastogenesis (2008)

Compounds isolated from members of the Zingiberaceae family are traditionally used as a medicine against inflammatory diseases, but little is known about the mechanism. Here, we report the isolation and structural identification of coronarin D [E-labda-8(17),12-diene-15-ol], a labdane-type diterpene, from Hedychium coronarium and delineate its mechanism of action. Because the transcription factor nuclear factor-kappaB (NF-kappaB) is a key mediator of inflammation, apoptosis, invasion, and osteoclastogenesis, we investigated the effect of coronarin D on NF-kappaB activation pathway, NF-kappaB-regulated gene products, and NF-kappaB-regulated cellular responses. The coronarin D inhibited NF-kappaB activation induced by different inflammatory stimuli and carcinogens. This labdane also suppressed constitutive NF-kappaB activity in different cell lines and inhibited IkappaBalpha kinase activation, thus leading to the suppression of IkappaBalpha phosphorylation, degradation, p65 nuclear translocation, and reporter gene transcription. Coronarin D also inhibited the NF-kappaB-regulated gene products involved in cell survival (inhibitor of apoptosis protein 1, Bcl-2, survivin, and tumor necrosis factor receptor-associated factor-2), proliferation (c-myc, cyclin D1, and cyclooxygenase-2), invasion (matrix metalloproteinase-9), and angiogenesis (vascular endothelial growth factor). Suppression of these gene products by the diterpene enhanced apoptosis induced by TNF and chemotherapeutic agents, suppressed TNF-induced cellular invasion, and abrogated receptor activator of NF-kappaB ligand-induced osteoclastogenesis. Coronarin D was found to be more potent than its analogue coronarin D acid. Overall, our results show that coronarin D inhibited NF-kappaB activation pathway, which leads to inhibition of inflammation, invasion, and osteoclastogenesis, as well as potentiation of apoptosis.
Locally repairable codes (2012)

One main challenge in the design of distributed storage codes is the Exact Repair Problem: if a node storing encoded information fails, to maintain the same level of reliability, we need to exactly regenerate what was lost in a new node. A major open problem in this area has been the design of codes that i) admit exact and low cost repair of nodes and ii) have arbitrarily high data rates. In this paper, we are interested in the metric of repair locality, which corresponds to the the number of disk accesses required during a node repair. Under this metric we characterize an information theoretic trade-off that binds together locality, code distance, and storage cost per node. We introduce Locally repairable codes (LRCs) which are shown to achieve this tradeoff. The achievability proof uses a “locality aware” flow graph gadget which leads to a randomized code construction. We then present the first explicit construction of LRCs that can achieve arbitrarily high data-rates.
An HMM-based multi-sensor approach for continuous mobile authentication (2015)

With the increased popularity of smart phones, there is a greater need to have a robust authentication mechanism that handles various security threats and privacy leakages effectively. This paper studies continuous authentication for touch interface based mobile devices. A Hidden Markov Model (HMM) based behavioral template training approach is presented, which does not require training data from other subjects other than the owner of the mobile device and can get updated with new data over time. The gesture patterns of the user are modeled from multiple sensors - touch, accelerometer and gyroscope data using a continuous left-right HMM. The approach models the tap and stroke patterns of a user since these are the basic and most frequently used interactions on a mobile device. To evaluate the effectiveness of the proposed method a new data set has been created from 42 users who interacted with off-the-shelf applications on their smart phones. Results show that the performance of the proposed approach is promising and potentially better than other state-of-the-art approaches.
Investigating the Performance of Tantalum Carbide Supported Iridium-Based Catalyst for Polymer Electrolyte Membrane Water Electrolysis (2020)

Hydrogen from polymer electrolyte membrane (PEM) water electrolysis has been identified as a key enabler for the transition to low/no-carbon energy from renewable energies. Polymer electrolyte membrane water electrolysis can be used to generate hydrogen from surplus energy generated using renewable energy technologies. Iridium is currently considered a state-of-the-art catalyst for the oxygen evolution reaction. However, it is a rare noble metal and as such a surge in demand would increase the cost of PEM water electrolyser units. One of the main strategies employed is the reduction of the noble metal loading through the use of supports. Tantalum carbide supported iridium based catalysts have been shown to be potential candidates for use as oxygen evolution reaction (OER) catalysts for water electrolysis. In this study, the performance of IrO x /TaC catalyst prepared using a surfactant mediated method is presented. IrO x /TaC catalysts were synthesized and fabricated into membrane electrode assemblies (MEAs). Nafion 115 was used as the membrane for the MEAs. Ir:TaC ratio was varied and its effect on the electrolyser performance was observed. The ionomer loading in the anode was also varied at the different Ir:TaC ratios and the performance observed. The elemental distribution of the IrO x /TaC was determined using scanning transmission electron microscopy (STEM)/energy dispersive spectroscopy (EDS). The conductivities of the catalysts and MEAs were also determined. Scanning electron microscopy (SEM) was used to analyse the morphology and elemental distribution of the electrode surfaces and the cross-section of the MEAs. The electrochemical performance of the MEAs was then tested in a single cell electrolyser equipped with an in-situ reference electrode. Current-voltage (I-V) curves were obtained potentiostatically at 80 °C. It was observed that while the fabricated MEAs had lower loading of iridium in the electrode, their performance was comparable with those found in literature.
Hydraulic Fracturing Design and Optimization: A Modification to Zipper Frac (2012)

Abstract In recent years, new fracturing designs and techniques have been developed to enhance production of trapped hydrocarbons. The new techniques focus on reducing stress contrast during fracture propagation while enhancing far field complexity and maximizing the stimulated reservoir volume. Zipper frac is one of these techniques, which involves simultaneous stimulation of two parallel horizontal wells from toe to heel. In this technique, created fractures in each cluster propagate toward each other so that the induced stresses near the tips force fracture propagation to a direction perpendicular to the main fracture. The effectiveness of zipper frac has been approved by the industry; however, the treatment's optimization is still under discussion. In this paper, we present a new design to optimize fracturing of two laterals from both rock mechanic and fluid production aspects. The new design is a modification to zipper frac, where fractures are initiated in a staggered pattern. The effect of well spacing on the changes in normal stress has been evaluated analytically to optimize the design. Results demonstrate that the modified zipper frac improves the performance of fracturing treatment when compared to the original zipper frac by means of increasing contact area and eventually enhancing fluid production.
Gold-Decorated Block Copolymer Microspheres with Controlled Surface Nanostructures (2012)

Gold-decorated block copolymer microspheres (BCP-microspheres) displaying various surface morphologies were prepared by the infiltration of Au precursors into polystyrene-b-poly(4-vinylpyridine) (PS-b-P4VP) microspheres. The microspheres were fabricated by emulsifying the PS-b-P4VP polymers in chloroform into a surfactant solution in water, followed by the evaporation of chloroform. The selective swelling of the P4VP domains in the microspheres by the Au precursor under acidic conditions resulted in the formation of Au-decorated BCP-microspheres with various surface nanostructures. As evidenced by transmission electron microscopy (TEM) and scanning electron microscopy (SEM) measurements, dotted surface patterns were formed when microspheres smaller than 800 nm were synthesized, whereas fingerprint-like surface patterns were observed with microspheres larger than 800 nm. Au nanoparticles (NPs) were located inside P4VP domains near the surfaces of the prepared microspheres, as confirmed by TEM. The optical properties of the BCP-microspheres were characterized using UV-vis absorption spectroscopy and fluorescence lifetime measurements. A maximum absorption peak was observed at approximately 580 nm, indicating that Au NPs are densely packed into P4VP domains on the microspheres. Our approach for creating Au-NP-hybrid BCP-microspheres can be extended to other NP systems such as iron-oxide or platinum NPs. These precursors can also be selectively incorporated into P4VP domains and induce the formation of hybrid BCP-microspheres with controlled surface nanostructures.
Elevated Plasma Atrial Natriuretic Factor and Vasopressin in High-Altitude Pulmonary Edema (1988)

A diagnosis of acute high-altitude pulmonary edema was made in five male skiers (age, 35.0 +/- 1.8 years) by history and physical examination and was confirmed by a characteristic chest radiogram showing alveolar infiltrates associated with a normal cardiac silhouette. Five healthy age- and sex-matched subjects with similar physical activity at the same altitude served as controls. Plasma sodium was 135.0 +/- 1.5 mmol/L in the acutely ill patients compared with 144.0 +/- 3.3 mmol/L in the controls (P less than 0.025). Mean plasma atrial natriuretic factor immunoreactivity averaged 17.6 +/- 5.6 pmol/L in patients with high-altitude pulmonary edema compared with 6.8 +/- 0.7 pmol/L in the controls at the same altitude (P less than 0.05). Elevated atrial natriuretic factor levels normalized to 7.5 +/- 1.9 pmol/L (P less than 0.05) during recovery in Denver (altitude, 1600 meters) 24 hours later. Plasma arginine vasopressin levels were 1.8 +/- 0.37 pmol/L in patients with high-altitude pulmonary edema at diagnosis compared with 0.92 +/- 0.28 pmol/L in controls (P = 0.07). The inappropriately elevated arginine vasopressin levels decreased to 1.29 +/- 0.37 pmol/L during recovery (P less than 0.025), but the lowered plasma sodium concentration had not normalized by discharge within 24-hours of transfer to Denver and averaged 135.8 +/- 1.2 mmol/L. The pathophysiologic implications of these findings are discussed.
A protocol for seamless communication in a picocellular network (2002)

Present an architecture for a picocellular network and presents a novel communication protocol for mobile users in such networks. The cell size in these networks is very small-typically of the order of a room in a building, resulting in an environment where the movement between cells is very rapid. This makes the problem of maintaining communication between a pair of mobile users non-trivial. The present communication protocol uses groups to maintain communication between two mobile users. Groups are special collections of picocells and represent regions where a mobile user is likely to be located in the near future. Thus, messages addressed to this mobile user are multicast to all the picocells in the group guaranteeing delivery and obviating the need for messages to be forwarded between picocells. The mobile users will therefore see lower delays in message delivery times.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Impact of variability effects on FinFET transistors and combinational cells (2016)

This work provides a predictive evaluation of PVT variability impact on sub-22nm FinFET devices and a set of combinational cells. Results show that metal gate workfunction fluctuation is the main source of process variability, severely affecting the OFF current especially on NFET devices. Combinational cells suffer from temperature impact on the power consumption and also from voltage drop that increases more than three times the timing results of the majority of cells.
FMI Logs Deblurring and Inpainting Using Deep Learning (2023)

Summary Micro-resistivity image logs have been utilized widely for studying the geological features of drilled formations. These image logs contain significant information required for their correct interpretation. Unfortunately, due to the design of the Formation Micro Imager (FMI) tool, a considerable portion of data is missing from the final image log and is visualized as blank stripes. Missing data can severely threaten the correct interpretation of the FMI logs. In addition, some other artifacts, like image blur appearing because of the complex operational conditions, may significantly affect the data quality, complicating the interpretation process. In this work, the Deep Image Prior (DIP) deep learning technique was utilized for the inpainting of FMI logs. Furthermore, the DIP was applied to inpainting several outcrop images to mimic the FMI log image restoration. Then, the restored outcrop images were compared to the original to assess the inpainting goodness and answer the question of how close the restored FMI logs might be to the “reality.” Finally, DIP with regularization by denoising (RED) was utilized to demonstrate the example of FMI log deblurring. The study has shown that applying both techniques may be a viable approach for restoring corrupted FMI logs completely.
Hydrostatic balloon dilatation for stomal stenosis after gastric partitioning. (1984)

Hydrostatic balloon dilatation has been used successfully to treat several patients with stomal stenosis occurring as a late complication of gastroplasty. The technique of hydrostatic balloon dilatation practiced in this institution is reviewed in detail. This technique appears to offer several advantages over previous techniques: 1) the procedure can be accomplished with intravenous sedation eliminating the need for general anesthesia; 2) trauma to the gastric channel is minimized because no attempt is made to manipulate the endoscope through the stoma into the distal stomach; 3) radiopaque markers on the polyethylene balloon catheter permit easy and accurate positioning of the balloon within the gastric channel; 4) the low compliance characteristics of the polyethylene balloon used permit inflation to a predetermined outer diameter with minimum risk of balloon deformity or overdistention and rupture; and 5) the procedure is easily standardized and can therefore be expected to yield reproducible results. Late stomal stenosis after gastric partitioning may respond to conservative therapy including nutritional support and dietary counselling. Hydrostatic balloon dilatation should be considered as the preferred method of stomal dilatation in patients refractory to alternative forms of management.
A Fourier based algorithm for tracking SPAMM tags in gated magnetic resonance cardiac images (1996)

A method is described for automatically tracking spatial modulation of magnetization tag lines on gated cardiac images. The method differs from previously reported methods in that it uses Fourier based spatial frequency and phase information to separately track horizontal and vertical tag lines. Use of global information from the frequency spectrum of an entire set of tag lines was hypothesized to result in a robust algorithm with decreased sensitivity to noise. The method was validated in several ways: first, actual tagged cardiac images at end diastole were deformed known amounts, and the algorithm's predictions compared to the known deformations. Second, tagged, gated images of the thigh muscle (assumed to have similar signal to noise characteristics as cardiac images, but to not deform with time) were created. Again the algorithmic predictions could be compared to the known (zero magnitude) deformations and to thigh images which had been artificially deformed. Finally, actual cardiac tagged images were acquired, and comparisons made between manual, visual, determinations of tag line locations, and those predicted by the algorithm. At 0.5 T, the mean bias of the method was < 0.34 mm even at large deformations and at late (noisy) times. The standard deviation of the method, estimated from the tagged thigh images, was < 0.7 mm even at late times. The method may be expected to have even lower error at higher field strengths.
Histomoniasis and Reticuloendotheliosis in a Wild Turkey (Meleagris gallopavo) in North Carolina (1989)

A moribund wild turkey (Meleagris gallopavo) died shortly after it was discovered in Martin County, North Carolina (USA). The 4.3-kg female turkey appeared in good condition with no visible external lesions or evidence of injury. There were 2- to 5-mm yellow-white plaques on the mucosal surfaces of the oral cavity and mid-esophagus. The liver had large, multifocal, irregular pale areas on cut and uncut surfaces. The spleen contained multifocal, pale, hard, nodules. Microscopic changes in the liver consisted of large multifocal coalescing areas of necrosis. Occasional spherical 10 to 15 μm in diameter organisms consistent with Histomonas meleagridis were present in the necrotic areas. Viable hepatic parenchyma contained multifocal infiltrations of numerous mononuclear cells interpreted as neoplastic cells resembling lymphoblasts and plasma cells. Similar neoplastic cell infiltrates, consistent with the lymphoproliferative disease reticuloendotheliosis, were present in spleen, lung, and esophageal and oral mucosa. Reticuloendotheliosis virus, subtype 2, was isolated from samples of liver and spleen.