gebhart/patrepeval huggingface dataset:
Design of two-dimensional waveguide head-up display (2018)

The strive for the small volume and light weight in head-up displays has made the conventional configuration combining relay optics and combiner unpractical any more. In this paper, a compact and light-weight head-up display with a large eyebox is designed, with two orthogonal geometrical waveguides adopted to extend the exit pupil in both directions. This two-dimensional waveguide acts as a pupil expander, which can also save the whole system from the trouble of severe aberrations. A triangular prism serves as the input-coupling and the partially reflective mirrors array is used as the output-coupling. Parameters to shape the combined waveguide are derived. The spherical surface based coaxial projection system to match the combined waveguide are designed to project and magnify the virtual image onto a surface at infinity. The compact head-up display integrating projection optics and the combined waveguide has a horizontal field of 20&deg;, with an eyebox of 80 mmx80 mm.
Synthesis of Bis(2-arylquinolin-4-yl)amines by Lithium Bis(trimethylsilyl)amide-Mediated Cyclization of Ketimines Derived from 2-(Trifluoromethyl)anilines and Aryl Methyl Ketones (1997)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTSynthesis of Bis(2-arylquinolin-4-yl)amines by Lithium Bis(trimethylsilyl)amide-Mediated Cyclization of Ketimines Derived from 2-(Trifluoromethyl)anilines and Aryl Methyl KetonesLucjan Strekowski, Lubomir Janda, and Hyeran LeeView Author Information Department of Chemistry, Georgia State University, Atlanta, Georgia 30303 Cite this: J. Org. Chem. 1997, 62, 12, 4193–4196Publication Date (Web):June 13, 1997Publication History Received21 January 1997Published online13 June 1997Published inissue 13 June 1997https://pubs.acs.org/doi/10.1021/jo970101ohttps://doi.org/10.1021/jo970101obrief-reportACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views418Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Anions,Chromatography,Cyclization,Ions,Mixtures Get e-Alerts
Paraneoplastic Neurological Syndromes and Glutamic Acid Decarboxylase Antibodies (2015)

Patients with GAD-abs must be screened for an underlying cancer if they have clinical presentations different from those typically associated with this autoimmunity or develop classic PNS. The risk for cancer increases with age, male sex, and the presence of coexisting neuronal cell-surface antibodies.
Determining the Economics of New Moulder Configurations (2009)

The moulder is one of the most widely used machines in the wood industry. Its function is to cut stock with rough dimensions to a finished width, thickness, and cross-sectional shape in one pass, making it cost effective to produce mouldings, floors, window and furniture components, etc. Today’s moulders are fast, safe, flexible, versatile, precise, and productive. Many different configurations can be selected when specifying the purchase of a moulder. The Moulder Economic Calculator (MEC) was developed to determine the economic impact of choosing different moulder configurations. The calculator uses input data on machine price and purchase method, machine configuration, production parameters, and production costs. The MEC program gives three types of outputs: surface quality, productivity, and costs. The MEC program is a flexible tool that allows the user to estimate the cost of machining one linear foot of wood. Some capabilities of the MEC program include determining the effect of machine price on machining cost, the effect of setup time on production time, and the effect of machine configuration on machining cost. In this way, the MEC program allows the user to compare between different machine configurations and determine which best meets the user’s cost, production, or flexibility requirements. The model was taken to Weinig USA, where their experts reviewed the model and offered their input.
Variance Soft Shadow Mapping (2010)

Abstract We present variance soft shadow mapping (VSSM) for rendering plausible soft shadow in real‐time. VSSM is based on the theoretical framework of percentage‐closer soft shadows (PCSS) and exploits recent advances in variance shadow mapping (VSM). Our new formulation allows for the efficient computation of (average) blocker distances, a common bottleneck in PCSS‐based methods. Furthermore, we avoid incorrectly lit pixels commonly encountered in VSM‐based methods by appropriately subdividing the filter kernel. We demonstrate that VSSM renders high‐quality soft shadows efficiently (usually over 100 fps) for complex scene settings. Its speed is at least one order of magnitude faster than PCSS for large penumbra.
Human Lung Fibroblast Subpopulations with Different C1q Binding and Functional Properties (1992)

Human lung fibroblasts differing in C1q binding, steady-state levels of collagen synthesis, and other functional properties were isolated. Explants of normal human lung specimens were cultured in medium containing complement-inactivated plasma-derived human serum or complete human serum. Cells obtained were treated with C1q and fluorescein isothiocyanate-anti-C1q antibody and separated based on fluorescence intensity in a fluorescence-activated cell sorter (FACS). FACS profiles showed that fibroblasts obtained in the presence of plasma-derived serum (HF cells) displayed higher fluorescence intensity than those obtained in complete serum (LF cells). The unsorted and sorted HF and LF fibroblasts retained their respective fluorescence phenotypes after subculture. The LF fibroblasts proliferated faster than HF cells and contained more cycling cells. However, whereas the sorted HF cells grew normally, sorted LF cells grew poorly. Collagen production and pro alpha l[I] mRNA levels in HF cells were 2.6 +/- 0.7 and 2.1 +/- 0.6 times as high as LF cells (n = 4). Collagen synthesis in both HF and LF cells was stimulated by transforming growth factor-beta and inhibited by interferon-gamma, but the stimulation was greater and inhibition less in LF cells. Our results indicate that C1q binding and the type of C1q receptors can serve as markers for fibroblast subpopulations differing in collagen synthesis, and that selection of subpopulations and their differential sensitivity to regulatory molecules can contribute to collagen alterations associated with inflammation, fibrosis, and other acquired diseases.
Nouvelles surfaces nanotubulaires par électropolymerisation avec une très forte adhésion à l’eau (2017)

International audience
An analysis of process heat recovery in a gas-solid shallow fluidized bed (2006)

This work presents an experimental study of a continuous gas-solid fluidized bed with an immersed horizontal tube. Silica sand (254mm diameter) was used as solid particles and air was used for fluidization in a 900mm long and 150mm wide heat exchanger. Measurements were made under steady state conditions for a solid particle mass flow rate from 14 to 95kg.h-1 and a number of baffles from 0 to 8. Results showed that the heat transfer coefficient increases with the solid particle mass flow rate and with the number of baffles, suggesting that these are important factors to be considered in the design of such equipment. An empirical correlation for the heat transfer coefficient is proposed as a function of solid particle and gas mass flow rate, number of baffles and gas velocity.
Synthesis of Multivalent Glycoclusters from 1-Thio-β-d-galactose and Their Inhibitory Activity against the β-Galactosidase from E. coli (2011)

The synthesis of multivalent glycoclusters, designed to be compatible with biological systems, is reported. A variety of 1-thio-β-D-galactosides linked to a terminal triple bond through oligoethyleneglycol chains of variable lengths has been synthesized. Also, azide-containing oligosaccharide scaffolds were prepared from trehalose, maltose, and maltotriose by direct azidation with NaN(3)/PPh(3)/CBr(4). Click reaction between the thiogalactoside residues and the azide scaffolds under microwave irradiation afforded a family of glycoclusters containing 1 to 4 residues of 1-thio-β-D-galactose. The yields went from moderate to excellent, depending on the valency of the desired product. Deacetylation with Et(3)N/MeOH/H(2)O led to the final products. Complete characterization of the products was performed by NMR spectroscopy and HR-MS techniques. Their activities as inhibitors of β-galactosidase from E. coli were determined by using the Lineweaver-Burk method. The use of hydrophilic carbohydrate scaffolds for the synthesis of multivalent galactosides represents an interesting approach to improve their pharmacokinetics and bioavailability. In addition, the presence of the thioglycosidic bond will improve their stability in biological fluids.
Effect of Laser Cutting on Stretch Flangeability of High Strength Hot Rolled Steel Sheets (1985)

Effect of laser beam cutting on stretch flangeability of high strength hot rolled steel sheets having different chemical compositions was investigated and the results were discussed from metallurgical point of view.Hole notches with a diameter of 10mm were pierced by either laser beam cutting or mechanical punching method for hole expansion test.Laser beam cutting resulted in much higher stretch flangeability than mechanical punching because the former cut surface was smooth, defect-free and had thin heat-affected layer in contrast with a rugged punched surface containing a number of microvoids and thick work-hardened layer.Change in hole expanding ratio of laser cut steel sheet was well explained by the hardness of the heat affected layer.A carbon equivalent equation which agrees well with the variation in hardness was tentatively proposed by modifing the WES Ceq..It indicates that the steel sheet strengthened by the chemistry leading to less quench hardenability shows higher stretch flangeability.Increase in manganese sulfide inclusion markedly lowered stretch flangeability.
Synthesis of N-Aryl Hydrazides by Copper-Catalyzed Coupling of Hydrazides with Aryl Iodides (2001)

[reaction--see text] A convenient method for intermolecular N-arylation of hydrazides with substituted aryl iodides in the presence of a copper catalyst and Cs(2)CO(3) is reported. The C-N coupling of N-Boc hydrazine with para- and meta-substituted aryl iodides afforded the N-arylated products A, regioselectively. A reversal in regioselectivity is observed for the arylation of benzoic hydrazide with ortho-substituted aryl iodides, providing the N'-arylated products B.
Synthesis and surface immobilization of antibacterial hybrid silver-poly(l-lactide) nanoparticles (2014)

Infections associated with medical devices are a substantial healthcare problem. Consequently, there has been increasing research and technological efforts directed toward the development of coatings that are capable of preventing bacterial colonization of the device surface. Herein, we report on novel hybrid silver loaded poly(L-lactic acid) nanoparticles (PLLA-AgNPs) with narrowly distributed sizes (17 ± 3 nm) prepared using a combination of solvent evaporation and mini-emulsion technology. These particles were then immobilized onto solid surfaces premodified with a thin layer of allylamine plasma polymer (AApp). The antibacterial efficacy of the PLLA-AgNPs nanoparticles was studied in vitro against both gram-positive (Staphylococcus epidermidis) and gram-negative (Escherichia coli) bacteria. The minimal inhibitory concentration values against Staphylococcus epidermidis and Escherichia coli were 0.610 and 1.156 μg · mL(-1), respectively. The capacity of the prepared coatings to prevent bacterial surface colonization was assessed in the presence of Staphylococcus epidermidis, which is a strong biofilm former that causes substantial problems with medical device associated infections. The level of inhibition of bacterial growth was 98%. The substrate independent nature and the high antibacterial efficacy of coatings presented in this study may offer new alternatives for antibacterial coatings for medical devices.
DBCache (2002)

Many e-Business applications today are being developed and deployed on multi-tier environments involving browser-based clients, web application servers and backend databases. The dynamic nature of these applications necessitates generating web pages on-demand, making middle-tier database caching an effective approach to achieve high scalability and performance [3]. In the DBCache project, we are incorporating a database cache feature in DB2 UDB by modifying the engine code and leveraging existing federated database functionality. This allows us to take advantage of DB2's sophisticated distributed query processing power for database caching. As a result, the user queries can be executed at either the local database cache or the remote backend server, or more importantly, the query can be partitioned and then distributed to both databases for cost optimum execution.DBCache also includes a cache initialization component that takes a backend database schema and SQL queries in the workload, and generates a middle-tier database schema for the cache. We have implemented an initial prototype of the system that supports table level caching. As DB2's functionality is extended, we will be able to support subtable level caching, XML data caching and caching of execution results of web services.
Solubility of vesicular stomatitis virus M protein in the cytosol of infected cells or isolated from virions (1990)

The peripheral membrane M protein of vesicular stomatitis virus purified by detergent extraction of virions and ion-exchange chromatography was determined to be a monomer in the absence of detergent at high salt concentrations. Reduction of the ionic strength below 0.2 M resulted in a rapid aggregation of M protein. This self-association was reversible by the detergent Triton X-100 even in low salt. However, aggregation was not reversible by high salt concentration alone. M protein is initially synthesized as a soluble protein in the cytosol of infected cells, thus raising the question of how the solubility of M protein is maintained at physiological ionic strength. Addition of radiolabeled M protein purified from virions to unlabeled cytosol from either infected or uninfected cells inhibited the self-association reaction. Cytosolic fractions from infected or uninfected cells were equally effective at preventing the self-association of M protein. Self-association could also be prevented by an irrelevant protein such as bovine serum albumin. Sedimentation velocity analysis indicated that most of the newly synthesized M protein is monomeric, suggesting that the solubility of M protein in the cytosol is maintained by either low-affinity interaction with macromolecules in the cytosol or interaction of a small population of M-protein molecules with cytosolic components.
Regenerable temperature-responsive biocatalytic nanofiltration membrane for organic micropollutants removal (2021)

Biocatalytic nanofiltration membranes (BNMs) exhibit great potentials in organic micropollutants removal attributed to its synergistic effect between enzyme catalysis and membrane separation. However, the difficulties in regeneration of the BNMs halted their economic practicality. Inspired by cell membranes with stimuli-responsive channels, we have developed the temperature-responsive BNMs with nanogating function by poly(N-isopropyl acrylamide) (PNIPAM) modification. PNIPAM modification increases the geometric confinement of the support layer to enzymes, thus improving enzyme loading, inhibiting enzyme leakage, and preventing membrane permeability decline caused by enzyme excess migration and aggregation. By optimizing the concentration of reaction monomers, modification time, and strategies, the PNIPAM-based BNMs show high bisphenol A (BPA) removal efficiency and long-term stability. Furthermore, the PNIPAM-polyethyleneimine-based BNMs can be easily regenerated at 38°C, and the laccase activity and BPA removal efficiency are fully recovered. This work would promote the real application of BNMs in bioconversion, drug delivery, and biosensors.
Mutual coupling reduction between dual polarized microstrip patch antennas using compact spiral artificial magnetic conductor (2011)

In this paper, we present a dual polarized microstrip antenna above an Artificial Magnetic Conductor (AMC). It is printed on a high permittivity substrate (e r =9.82). The AMC is used in order to reduce the mutual coupling between two radiating elements. Two experimental prototypes are realized in order to validate the analysis. First, the performances of a patch antenna above AMC are analyzed. The return loss is less than −15 dB at 1.62 GHz. The measured radiation pattern shows that the antenna has a broadside gain of 7 dB and a cross-polar level about −15 dB. Then, the mutual coupling between two antennas above AMC is studied. 3 dB enhancement of mutual coupling compared to the array without AMC is observed at the operating frequency 1.62 GHz in H plane configuration. A good agreement between measurements and simulations results is observed.
EGFR first- and second-generation TKIs—there is still place for them in EGFR -mutant NSCLC patients (2018)

Identification of epidermal growth factor receptor (EGFR) as a molecular target has radically changed the treatment of metastatic non-small cell lung cancer (NSCLC) from standard chemotherapy to personalized, targeted therapy. First-, second- and third-generation EGFR tyrosine kinase inhibitors (TKIs) are now available for the treatment of EGFR-mutant NSCLC patients. This review will focus on the clinical development of first- and second-generation EGFR TKIs. We will emphasize on essential points like the head-to-head comparison among EGFR TKIs, their activity on brain metastases, mechanisms of resistance, as well as their combination with anti-angiogenic compounds, other targeted therapies, or immunotherapy. The efficacy of first- and second-generation EGFR TKIs in early-stage EGFR -mutant NSCLC will be also finally reviewed.
Passive Heat Recovery System Using Combination of Heat Pipe and Thermoelectric Generator (2015)

A different ways of waste heat recovery and conversion to electricity using a thermoelectric generator (TEG) assisted by heat pipes is introduced in this paper. The system consists of the TEG sandwiched between two heat pipes, one connected to the hot side of the TEG and the second one connected to the cold side of TEG. Experiments were conducted for a proof of concept of such system, and the experimental result was used to validate the theoretical model developed. It was found that both the experimental and the theoretical results share the same graphical trend in term of the rate of heat transfer and the effectiveness of heat exchanger. Further investigation in the theoretical model can narrow down the error.
Six Principles for Successful Data-Driven Service Innovation in Industrial Companies (2018)

Data-driven services play an important role in innovative business models of successful manufacturing companies: They hold great potential for the creation of unique selling points and improve the differentiation of manufacturing companies in highly competitive markets. However, the large number of newly invented digital services that fail shortly after launching implies that companies struggle with the invention and implementation of data-driven service solutions, which ends in a waste of resources. The following paper introduces guideline principles for successful innovation processes for data-driven services. The principles were identified during in-depth case studies with manufacturing companies. They contribute to a necessary paradigm change for manufacturing companies in terms of data-driven services for machines. The six identified principles emphasize new aspects regarding the new dimension of data-driven solutions and improve the life cycle management of products and services. They demonstrate how the rules of agile development can lead to successful and more efficient service innovations in the industrial sector.
Phenotypic heterogeneity in familial alzheimer's disease: A study of 24 kindreds (1989)

We report the clinical and neuropathological characteristics occurring in 180 demented individuals from 24 kindreds with familial Alzheimer's disease (FAD). Each family had at least two affected generations, and at least one autopsy or brain biopsy was compatible with the diagnosis of AD. Forty-nine neuropathological specimens or reports were reviewed. Mean age of onset for the total group was 54.7 years +/- 11.5, with a large range of 30 to 84 years. Mean age at death was 63.5 years +/- 12.2, with a range of 46 to 85. Mean duration of disease was 8.8 years +/- 4.4, with a range of 1 to 23 years. Six findings suggested phenotypic heterogeneity in FAD. (1) Five families represented an early age of onset group with mean onset at 42 years (range 30 to 51 years) and mean disease duration of 6.7 years. (2) Eight families represented a late onset group with mean onset at 68 years (range 59 to 78 years) and a mean duration of 8.5 years. (3) Seven families were of Volga German ancestry, all originating from the same two villages in Russia. Mean age of onset was 55.9 years (range 40 to 72 years), with a mean disease duration of 10 years. This group probably represents the genetic founder effect of an autosomal dominant gene for AD. (4) One family had the unusual characteristics of neurofibrillary tangles and granulovacuolar change but no amyloid plaques, a mean disease duration of more than 11 years, and a "schizophrenia-like" onset. (5) One family with late onset also had clinical and pathological evidence for anterior horn cell disease. (6) Two autopsies in 1 family both showed remarkable rarefaction of myelin and expansion of perivascular spaces in centrum semiovale (état criblé), with marked leptomeningeal and cortical amyloid angiopathy, distinct from the other FAD brains. It remains to be determined whether the clinical and pathological differences between these families represent genetic heterogeneity at the biochemical or molecular level.