gebhart/patrepeval huggingface dataset:
Performance degradation due to multiprogramming and system overheads in real workloads (1990)

In this paper, performance degradation specifically due to the multiprogramming (MP) overhead in a parallel execution environment is quantified. In addition, total system overhead is also measured. A methodology, which estimates the MP overhead present in real workloads, is illustrated with real measurements taken on an Alliant FX/80 running Xylem (Cedar's operating system). It is found that MP overhead usually consumes between 10% and 23% of the processing power available to parallel programs. Total system overhead usually consumes between 12% and 30% of the parallel environment processing power, but is found to be as high as 82.1%. The mean MP overhead is determined to be 16% which is well over half the total system overhead executed on the system (the mean system overhead is determined to be 24% of the processing power). It is found that MP overhead, total system overhead, and application completion time are all moderately correlated. Relationships between the characteristics of a workload and the overhead measurements indicate that processor utilization and to a lesser degree paging are moderately correlated with the overhead present in the workload. It is also found that MP overhead is statistically independent of the number of parallel jobs in the system, while total system overhead is not.
Elastic wall properties and collagen content in the ureter: An experimental study in pigs (1994)

We used an impedance planimetric method to look at elastic wall properties of ureter in ten anaesthetized pigs. A balloon was stepwise inflated and deflated in the ureteropelvine junction, in the mid-ureter, and in the intramural part of the ureter at the ureterovesical junction with pressures up to 70 cmH2O, while the pressure and balloon cross-sectional area (Bcsa) were measured simultaneously. The elastic wall parameters were calculated from these measurements. At sacrifice, tissue samples were collected for analysis of collagen content of the ureteral wall. A non-linear clockwise relation (hysteresis loops) between Bcsa and balloon pressure was demonstrated. At maximal inflation of the balloon, the Bcsa, wall tension, and compliance were 35.28 +/- 3.52, 38.44 +/- 3.23, and 61.36 +/- 8.09 mm2, 230.71 +/- 12.82, 242.38 +/- 10.49, and 302.17 +/- 20.03 cmH2O x m, and 0.167 +/- 0.047, 0.124 +/- 0.002, and 0.182 +/- 0.040 mm2 x cmH2O-1 in the intramural part of the ureter, middle part, and ureteropelvine junction, respectively. The collagen content was 0.3249 +/- 0.0077, 0.3301 +/- 0.0066, and 0.3457 +/- 0.0060 mg x mg-1 dry defatted weight in the intramural part, in the middle, and in the ureteropelvine junction, respectively. The collagen content of the ureteropelvine junction was significantly higher than that of the middle of ureter (P < 0.02) and than that of the intramural part (P < 0.05). No significant correlations were found between the elastic parameters at maximal inflation of the balloon and the collagen content (P < 0.10). In conclusion the elastic wall properties were significantly different in the three ureteral segments and the collagen content of the ureteropelvine junction differed from that of the two distal locations. However, no relationship between the wall properties and the collagen content was found.
Design, Synthesis and Biological Evaluation of 1,3,5-Triazine Derivatives Targeting hA1 and hA3 Adenosine Receptor (2022)

Adenosine mediates various physiological activities in the body. Adenosine receptors (ARs) are widely expressed in tumors and the tumor microenvironment (TME), and they induce tumor proliferation and suppress immune cell function. There are four types of human adenosine receptor (hARs): hA<sub>1</sub>, hA<sub>2A</sub>, hA<sub>2B</sub>, and hA<sub>3</sub>. Both hA<sub>1</sub> and hA<sub>3</sub> AR play an important role in tumor proliferation. We designed and synthesized novel 1,3,5-triazine derivatives through amination and Suzuki coupling, and evaluated them for binding affinities to each hAR subtype. Compounds <b>9a</b> and <b>11b</b> showed good binding affinity to both hA<sub>1</sub> and hA<sub>3</sub> AR, while <b>9c</b> showed the highest binding affinity to hA<sub>1</sub> AR. In this study, we discovered that <b>9c</b> inhibits cell viability, leading to cell death in lung cancer cell lines. Flow cytometry analysis revealed that <b>9c</b> caused an increase in intracellular reactive oxygen species (ROS) and a depolarization of the mitochondrial membrane potential. The binding mode of 1,3,5-triazine derivatives to hA<sub>1</sub> and hA<sub>3</sub> AR were predicted by a molecular docking study.
Supplementary Table S1 from Fibrinolytic Enzyme Cotherapy Improves Tumor Perfusion and Therapeutic Efficacy of Anticancer Nanomedicine (2023)

&lt;p&gt;Physicochemical characterization of paclitaxel nanoparticles.&lt;/p&gt;
Thermal Allylations of Aldehydes with a Fluorous Allylstannane. Separation of Organic and Fluorous Products by Solid Phase Extraction with Fluorous Reverse Phase Silica Gel (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTThermal Allylations of Aldehydes with a Fluorous Allylstannane. Separation of Organic and Fluorous Products by Solid Phase Extraction with Fluorous Reverse Phase Silica Gel†Dennis P. Curran, Sabine Hadida, and Mu HeView Author Information Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260Cite this: J. Org. Chem. 1997, 62, 20, 6714–6715Publication Date (Web):October 3, 1997Publication History Received12 June 1997Published online3 October 1997Published inissue 1 October 1997https://pubs.acs.org/doi/10.1021/jo9710590https://doi.org/10.1021/jo9710590rapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views1180Altmetric-Citations152LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Allylation,Chromatography,Extraction,Organic reactions,Silica Get e-Alerts
Regulation of Vesicular Traffic by a GTP-binding Protein on the Cytoplasmic Surface of Secretory Vesicles in Yeast (1988)

Vesicular transport is an important mechanism for the intracellular traffic of proteins and lipids in eukaryotic cells (Palade 1975). Vesicles mediate the passage of proteins between the various organelles of the secretory pathway and the exocytic release of these proteins into the extracellular environment. Vesicles also mediate the uptake of proteins and fluid from the external environment, delivering them to endosomes (Steinman et al. 1983). Despite the generality of the vesicular transport mechanism, the process is not yet understood at a molecular level. The key questions that must be addressed are (1) How are vesicles formed from the membrane of the donor organelle? (2) How are these vesicles transported? (3) How do the vesicles recognize the membrane of the target (acceptor) organelle? (4) How is membrane fusion accomplished? The genetic flexibility of yeast has been exploited to identify components of the cellular machinery required for vesicular transport (Novick and Schekman...
Trisodium citrate 46.7% selectively and safely reduces staphylococcal catheter-related bacteraemia (2008)

We found that 46.7% TSC is a safe, convenient and highly effective catheter locking solution, leading to significant reduction in CRB largely by preventing staphylococcal bloodstream infections. Given that Staphylococcus aureus in particular is associated with serious and often disseminated infection, TSC seems to be a powerful tool for dialysis units.
Depositing Controlled, Matched Resistors for Circuit Edit of Analog Circuitry (2015)

Abstract During a silicon debug, it was found that the gain of a radio receiver circuit dropped dramatically at certain frequencies due to an imbalance in one of the signal paths. A metal fix was proposed, but consensus could not be reached on how to validate it because of the difficulty of the FIB edit required and the inherent uncertainty of the approach. In this article, the authors explain how they came up with an alternative approach that proved to be faster, more reliable, and easier to validate than the cut-and-join fix initially proposed. They describe each step of the analog circuit editing process, explaining how they deposit, characterize, and connect matched resistors using focused ion beam techniques.
Rating sputum cell quality in clinical trials for asthma and COPD treatment (2019)

Background Induced sputum is a method to assess airway inflammation in clinical trials for asthma and COPD. 1–3 Sputum is a heterogeneous, viscous material containing inflammatory cell plugs, cellular debris, mucus, and saliva with squamous cells. The quality of sputum cell preparations for differential cell count analysis depends on multiple factors and can be highly variable. 4,5 Percentage of squamous cell contamination (SQ%) is often used to assess the quality of sputum cell preparations. 6 Here, we evaluated a comprehensive quality score, 7 which also includes an assessment of the inflammatory cell morphology and amount of cellular debris.
Impact Microindentation Assesses Periosteal Bone Matrix Quality in Humans (2019)

International audience
Imputación de rentas inmobiliarias en el IRPF y capacidad económica: ¿una controversia zanjada por la Sentencia del Tribunal Constitucional 295/2006, de 11 de octubre? (2007)

Este trabajo ha obtenido el 2.º Premio Estudios Financieros 2007 en la Modalidad de TRIBUTACIÓN. Desde la Ley 44/1978 hasta la reciente Ley 35/2006, los sucesivos cuerpos legales reguladores del Impuesto sobre la Renta de las Personas Físicas (IRPF) han previsto, sin excepción, la imputación de una renta por la propiedad o la titularidad de un derecho real de disfrute sobre determinados bienes inmuebles no cedidos a terceros, ni afectos a la realización de actividades económicas. En la actualidad entran dentro de su ámbito de aplicación los inmuebles urbanos, con la importante salvedad de la vivienda habitual del contribuyente y sus anejos, y algunos inmuebles rústicos, con la común condición de que no sean generadores de rendimientos del capital ni de actividades económicas. Sin embargo, la sujeción de este componente de renta al impuesto ha sido desde hace años una cuestión muy controvertida. Para justificar su gravamen se han aducido diversos argumentos, que van desde su consideración como una renta de disfrute o en especie, correspondiente a la utilidad obtenida por el uso o simple tenencia del inmueble a modo de autoconsumo, o incluso como una renta potencial a la que renuncia el sujeto pasivo que retiene el bien pudiendo cederlo a un tercero, hasta la invocación de razones extrafiscales de protección del derecho a la vivienda o de lucha contra el fraude fiscal. Por el contrario, la pervivencia de esta renta imputada ha sido fuertemente discutida por la doctrina, no solo por considerarla una renta ficticia e inexistente, cuya existencia resulta contraria al principio de capacidad económica (art. 31.1 de la Constitución), sino también porque supone una discriminación entre las diferentes formas de inversión y comporta una penalización fiscal a la tenencia de bienes inmuebles que encajaría mucho mejor en el seno de la imposición patrimonial (IP e IBI). La Sentencia del Tribunal Constitucional 295/2006, de 11 de octubre, ha mediado en esta polémica aportando algunas ideas interesantes. Al hilo de ellas efectuaremos algunas reflexiones críticas, toda vez que este pronunciamiento otorga un visto bueno, a nuestro juicio demasiado generoso, al legislador tributario para que conserve esta categoría como renta potencial dentro del objeto del IRPF.
Functionalized N(2-oxyiminoethyl) piperazinyl quinolones as new cytotoxic agents. (2007)

These studies demonstrate that introduction of O-benzylmoiety on oxime group of N-(2-oxyimino) piperazinyl quinolone series changes the biological profile of piperazinyl quinolones from antibacterial to cytotoxic activity. As can be deduced from these data, O-benzyl functionalized N-(2-oxyiminoethyl) piperazinyl quinolones have excellent potential as a new class of cytotoxic agents.
Plant-Type Trehalose Synthetic Pathway in Cryptosporidium and Some Other Apicomplexans (2010)

A trehalose synthetic pathway is described in the majority of apicomplexan parasites including Cryptosporidium and the presence of trehalose was confirmed in the C. parvum oocyst. Key enzymes in the pathway (i.e., T6PS-TPase and UGGPase) are plant-type and absent in humans and animals, and may potentially serve as novel drug targets in the apicomplexans.
The manager/agency paradigm for distributed network management (2002)

The manager/agent model has been the de facto paradigm used for designing network management systems. However, as the network size grows and new network and computing technology emerges, consistency, flexibility, reliability, and scalability issues of distributed network management systems might not be fully addressed within the model. This paper proposes an extension to the manager/agent model, called the manager/agency paradigm, to address these issues. In the manager/agency paradigm, a manager performs management functions through an agency of cooperating management entities, (lower-level) managers and/of agents, which are collaboratively working together to achieve consistent management goals. Agencies may recursively constitute other agencies, based on the layering and partitioning principles, to scale with ever growing network size. They may be organized flexibly according to different management functionalities, goals and policies, and may present a single management view to their (upper-level) managers by hiding management complexity. Inside an agency, various fault tolerant schemes, such as active replication or primary-backup approach, may be used to implement reliable management functionality transparently to its manager. The paper begins by describing the anatomy and semantics of an agency and comparing the manager/agency model against the manager/agent model. It then demonstrates its applications to address the consistency and reliability issues of network management problems. Finally, applications of the manager/agency model to the broader, distributed enterprise management is discussed.
Russian Presidential Academy of National Economy and Public Administration (North-West Institute of Management, Branch of RANEPA) (2020)

Comprehensive processes of digital change in socio-economic reality actualized and concentrated the attention of decision makers and scientists on the adaptation of administrative systems to new challenges. The state program “Digital Economy of the Russian Federation” contains a number of design areas for the digital transformation of the Russian public administration system. The system of election commissions of Russia was actively included in this program and formed a set of project initiatives that are designed to significantly change the appearance and content of the entire electoral system and the electoral process. It is obvious that the rapid nature of the ongoing external (global) and internal changes and challenges required flexible response methods. The project management methodology, according to the authors, is adequate to modern reality and is optimal when implementing initiatives aimed at information development. In the article, the authors examine in detail digital projects and digital services of the Russian electoral system, as well as form a series of proposals aimed at further improving project initiatives. The authors believe that from a scientific and applied point of view, the stake on the project approach in the implementation of digital projects is justified, especially in the context of a constant change in the strategic priorities of socio-economic development.
Approaches to Study Interactions Between Kinesin Motors and Membranes (2001)

Determining the subcellular location of molecular motors is an essential step in understanding their function and regulation. Although much attention has been focused on the ability of kinesin-like motors to bind reversibly to microtubules, the interaction of this family with cargo has not been extensively studied. Thus, the interactions of kinesin with membrane-bound organelles (MBOs) remains poorly understood, although kinesins are widely thought to serve as motors for movement of MBOs (see also Chapter 12). Methods presented in this chapter were developed to study the regulation of the membrane association of kinesins.
Interseismic coupling and seismic potential along the Central Andes subduction zone (2011)

We use about two decades of geodetic measurements to characterize interseismic strain build up along the Central Andes subduction zone from Lima, Peru, to Antofagasta, Chile. These measurements are modeled assuming a 3-plate model (Nazca, Andean sliver and South America Craton) and spatially varying interseismic coupling (ISC) on the Nazca megathrust interface. We also determine slip models of the 1996 M w = 7.7 Nazca, the 2001 M w = 8.4 Arequipa, the 2007 M w = 8.0 Pisco and the M w = 7.7 Tocopilla earthquakes. We find that the data require a highly heterogeneous ISC pattern and that, overall, areas with large seismic slip coincide with areas which remain locked in the interseismic period (with high ISC). Offshore Lima where the ISC is high, a M w $8.6-8.8 earthquake occurred in 1746. This area ruptured again in a sequence of four M w $8.0 earthquakes in 1940, 1966, 1974 and 2007 but these events released only a small fraction of the elastic strain which has built up since 1746 so that enough elastic strain might be available there to generate a M w > 8.5 earthquake. The region where the Nazca ridge subducts appears to be mostly creeping aseismically in the interseismic period (low ISC) and seems to act as a permanent barrier as no large earthquake ruptured through it in the last 500 years. In southern Peru, ISC is relatively high and the deficit of moment accumulated since the M w $8.8 earthquake of 1868 is equivalent to a magnitude M w $8.4 earthquake. Two asperities separated by a subtle aseismic creeping patch are revealed there. This aseismic patch may arrest some rupture as happened during the 2001 Arequipa earthquake, but the larger earthquakes of 1604 and 1868 were able to rupture through it. In northern Chile, ISC is very high and the rupture of the 2007 Tocopilla earthquake has released only 4% of the elastic strain that has accumulated since 1877. The deficit of moment which has accumulated there is equivalent to a magnitude M w $8.7 earthquake. This study thus provides elements to assess the location, size and magnitude of future large megathurst earthquakes in the Central Andes subduction zone. Caveats of this study are that interseismic strain of the forearc is assumed time invariant and entirely elastic. Also a major source of uncertainty is due to fact that the available data place very little constraints on interseismic coupling at shallow depth near the trench, except offshore Lima where sea bottom geodetic measurements have been collected suggesting strong coupling.
Thermal characterization of MBE-grown GaN/AlGaN/GaN device on single crystalline diamond (2011)

Self-heating effects in a molecular beam epitaxy-grown GaN/AlGaN/GaN structure on a single crystalline diamond is investigated. A transient interferometric method, in combination with a three dimensional model, is used to describe a pulsed operation of a transistor-like heater, and a micro-Raman technique is used in a steady state. Good agreement is found between the techniques. The thermal conductivity of the diamond is found to be 2200 W/m K, and the thermal boundary resistance to the III-N epi-structure is &amp;lt; 1 × 10−8 m2 K/W. The excellent cooling efficiency of the diamond is manifested by the fast saturation of the temperature at 1 μs and by a record low normalized thermal resistance of 3.5 K mm/W.
Experimental Demonstration of the Influence of Wing Couplings on Whirl- Flutter Instability (2000)

An experimental demonstration is presented of the ine uence and the effectiveness of tiltrotor wing couplings in postponing whirl ‐e utter instability in forward e ight. The experimental setup is based on a small-scale model wherethewingsuppliesa coupled elasticsupportbutdoesnot introduceanyaerodynamiccontribution.Theelastic deformation of the beam has been measured using a system of strain gauges at its root. Stability characteristics were calculated based on the recorded time history of the system response to an external abrupt disturbance. Beamwise bending ‐chordwise bending couplings were created by tilting the wing structure, whereas beamwise bending‐twist couplings were introduced by changing the nacelle length. Both types of the wing coupling effects were found ine uential. The results indicate that adequate exploiting of wing coupling effects has the potential to signie cantly improve the stability characteristics of coupled rotor ‐wing systems.
Cyclic Di-Adenosine Monophosphate: A Promising Adjuvant Candidate for the Development of Neonatal Vaccines (2021)

Underdeveloped immunity during the neonatal age makes this period one of the most dangerous during the human lifespan, with infection-related mortality being one of the highest of all age groups. It is also discussed that vaccination during this time window may result in tolerance rather than in productive immunity, thus raising concerns about the overall vaccine-mediated protective efficacy. Cyclic di-nucleotides (CDN) are bacterial second messengers that are rapidly sensed by the immune system as a danger signal, allowing the utilization of these molecules as potent activators of the immune response. We have previously shown that cyclic di-adenosine monophosphate (CDA) is a potent and versatile adjuvant capable of promoting humoral and cellular immunity. We characterize here the cytokine profiles elicited by CDA in neonatal cord blood in comparison with other promising neonatal adjuvants, such as the imidazoquinoline resiquimod (R848), which is a synthetic dual TLR7 and TLR8 agonist. We observed superior activity of CDA in eliciting T helper 1 (Th1) and T follicular helper (TfH) cytokines in cells from human cord blood when compared to R848. Additional in vivo studies in mice showed that neonatal priming in a three-dose vaccination schedule is beneficial when CDA is used as a vaccine adjuvant. Humoral antibody titers were significantly higher in mice that received a neonatal prime as compared to those that did not. This effect was absent when using other adjuvants that were reported as suitable for neonatal vaccination. The biological significance of this immune response was assessed by a challenge with a genetically modified influenza H1N1 PR8 virus. The obtained results confirmed that CDA performed better than any other adjuvant tested. Altogether, our results suggest that CDA is a potent adjuvant in vitro on human cord blood, and in vivo in newborn mice, and thus a suitable candidate for the development of neonatal vaccines.