gebhart/patrepeval huggingface dataset:
Factors Predictive of Relapse of Acute Leukemia in Children after Allogeneic Hematopoietic Cell Transplantation (2014)

The presence of minimal residual disease (MRD) before transplantation is the most important prognostic risk factor predictive of post-transplantation relapse in hematologic malignancies. However, MRD alone does not adequately predict relapse in all patients. To improve upon the ability to identify patients likely to relapse, we evaluated risk factors, in addition to MRD, that may be associated with development of post-transplantation relapse. In this single institution, retrospective cohort study of children with acute leukemia or myelodysplastic syndrome who had undergone a first allogeneic transplantation and had pretransplantation MRD evaluation, 40 of 93 patients (43%) experienced relapse. Univariate analysis demonstrated that African American race, high initial white blood cell count, central nervous system (CNS) disease at diagnosis, short first complete remission, nonmyeloablative (NMA) conditioning, lack of remission, and MRD before transplantation were associated with worse relapse-free survival (RFS). In a Cox multivariable analysis, CNS disease (P = .009), lack of remission (P = .01), and NMA conditioning (P = .04) were independently associated with inferior RFS. Among those in a morphologic complete remission who underwent a myeloablative transplantation, having both CNS disease at diagnosis (specifically in acute lymphoblastic leukemia) and MRD positivity was an independent risk factor predictive of relapse, which has not been previously reported. Results from our study support the existence of risk factors complimentary to pretransplantation MRD. Validation in a larger independent homogenous cohort is needed to develop a prognostic tool for clinical use to predict post-transplantation relapse.
CULVERT DURABILITY RATING SYSTEMS (1988)

We present a simple approach for the calculation of in vivo fluorescence excitation spectra from measured absorbance spectra of the isolated pigments involved. Taking into account shading of the pigments by each other, energy transfer from carotene to chlorophyll a, and light scattering by the leaf tissue, we arrive at a model function with 6 free parameters. Fitting them to the measured fluorescence excitation spectrum yields good correspondence between theory and experiment, and parameter estimates which agree with independent measurements. The results are discussed with respect to the origin and the interpretation of in vivo excitation spectra in general.
Structural Variability of Nucleosomes Detected by Single-Pair Förster Resonance Energy Transfer: Histone Acetylation, Sequence Variation, and Salt Effects (2008)

Nucleosomes were reconstituted from 170 bp long fragments of 5S rDNA and an optimal positioning sequence, the Selex 601, with recombinant histones. In free-solution single pair Förster resonance energy transfer (spFRET) measurements of the distance between fluorescently labeled bases in the nucleosomal DNA, the samples exhibited structural diversity. The structural heterogeneity correlated with the stability of the complexes and depended on the DNA sequence and histone acetylation. The stability of the nucleosomes was assessed via dilution-driven disruption: histone acetylation decreased nucleosome stability. The spFRET experiments used a new approach for data acquisition and analysis that we term "deliberately detuned detection" (D3). This permits the separation of subpopulations in the samples even for the low-FRET regime characteristic for the linker-DNA labeled nucleosomes. Thus, it became possible to study in more detail histone acetylation- and salt-dependent structural variations using either end- or internally labeled DNAs on the nucleosome. We found that the distance distribution of the fluorophore pairs on the linker DNA ends was much more sensitive to histone acetylation or sequence variation than that of labels on the internal part of the DNA, which was more tightly associated with the histone core. spFRET on freely diffusing nucleosomes allows us therefore to localize the influence of histone modifications and DNA sequence variations on the nucleosome structure and dynamics.
Dietary mannoheptulose does not alter glucose or lipid metabolism in adult Labrador Retrievers (2017)

Mannoheptulose (MH), a glycolytic inhibitor, has been preliminarily investigated as a novel functional food ingredient for dogs. This study aimed to determine the effects of dietary MH, delivered as an extract of un-ripened avocados, on fatty acid and glucose kinetics in healthy adult Labrador Retriever dogs (n = 12 dogs). The study was a double-blindcrossover with each dog receiving both dietary treatments, control (CON) and MH (400 mg/kg of diet), in random order. Glucose and glycerol plasma turnover (Ra) and oxidation (Ox) were measured in fasting and in response to repeated meal feeding ("fed") with stable isotope tracers (U-<sup>13</sup> C-glucose, 1,1,2,3,3-D<sub>5</sub> -glycerol) and indirect calorimetry. Palmitate Ra and Ox were examined during repeated meal feeding only using an oral bolus of U-<sup>13</sup> C-K<sub>2</sub> -palmitate and indirect calorimetry. MH had no discernible effect on fasting glucose Ra (677, 722 SEM 36 μmol/min, CON, MH) or Ox (107, 109 μmol/min, CON, MH SEM 10 μmol/min) or fed glucose Ra (2913, 3626 SEM 644 μmol/min, CON, MH) or Ox (951, 936 SEM 174 μmol/min, CON, MH). Glycerol Ra, an index of the rate of lipolysis, was not different between dietary treatments (Fast 162, 113 SEM 35 μmol/min CON, MH; Fed 172, 135 SEM 21 μmol/min, CON, MH). Similarly, palmitate oxidation was not impacted by MH feeding (1966, 2276 SEM 79 μmol/min, CON, MH). Together, these findings do not support MH as a novel functional food ingredient at least at the dietary dose tested.
It Pays to Test Your IRRIGATION PUMPING PLANT (1980)

A pumping plant performance test can determine the energy efficiency of an irrigation pumping plant and provIde information on adjustments needed to improve energy efficiency. The performance of an irrigation pumping plant should be evaluated by trained personnel using accurate testing equipment. This service can be performed by consulting engineers, by many well drilling companies, and some Natural Resources Districts and Public Power Districts. See your County Extension Agent for more information concerning these services. A pumping plant test should be performed regardless of the age of your system. Test all new systems so that you can be assured that your unit meets the contract specifications, which should be at least equal to the Nebraska Performance criteria for pumping plants (Table 1). The components must be carefully selected, installed, adjusted and operated to obtain these standard values. For an existing pumping plant a test can determine: 1. If energy and money can be saved by adjusting, rebuilding, or replacing the existing pump, drive systems, or power unit. 2. If the well is being operated at too great a discharge rate for existing pump and well conditions.
Activation of LA‐N‐2 cell phospholipases by single alanine substitution analogs of amyloid β peptide (25–35) (1997)

A series of single alanine substituted analogs of amyloid beta peptide (25-35) were tested for their ability to activate the phospholipases of cultured LA-N-2 cells. Substitution of alanine for the amino acids 29-34 prevented the activation of phospholipases A2 and D. In addition substitution of alanine at 28 prevented phospholipase D but not phospholipase A2 activation. All the alanine substitutions, except for positions 33 and 35, blunted phospholipase C activations. There were no activations by scrambled amyloid beta peptide.
Mitigating Drilling Dysfunction Using a Drilling Advisory System: Results from Recent Field Applications (2015)

Abstract The ExxonMobil Drilling Advisory System (DAS™) is a rig-based drilling surveillance and optimization platform that encourages regular (guided) drill-off tests, carefully monitors drilling performance and provides recommendations for controllable drilling parameters to help improve the overall drilling process. It is well known that drilling with dysfunction(s), such as BHA whirl or bit stick-slip, among others, can damage drilling tools, lead to poor borehole quality and result in significant reductions in Rate of Penetration (ROP). The ultimate objective of DAS is to help drillers achieve consistently better and longer bit runs by identifying and mitigating drilling dysfunctions. In this paper we describe the DAS workflow, provide an overview of many of the key technical components of DAS and summarize results from several recent field applications. The DAS workflow includes a learning (or calibration) mode that encourages the driller to explore different operating parameters by conducting drill-off tests, which in turn allows the system to build an understanding of performance trends. This understanding is then exploited by an application mode which leverages results obtained during the learning (or calibration) phase. The workflow is iteratively applied in real-time as drilling operations and geological conditions change. Key technical components of the DAS application include: high quality adaptive filtering algorithms for computing various drilling system performance measures (e.g., MSE, ROP, and stick-slip severity, among others), data encapsulation/dimensionality reduction techniques (i.e., the notion of "response points") and reduced order modeling techniques (simplices, smooth response surfaces, etc.) which are ultimately used to generate recommendations for improved performance. Using examples from recent offshore field applications, we illustrate the use of adaptive filtering and data encapsulation to process noisy real-time data and extract meaningful trends to enable drilling performance optimization. We show how fitting response surfaces to response points can help elucidate, in real-time, the occurrence of classical drilling dysfunctions such as lateral vibrations (as manifest in increased MSE) and stick-slip torsional vibrations. Using results from recent applications of DAS to unconventional pad-drilling operations, we show the impacts of focused drilling performance limiter redesign and real-time DAS parameter changes on improved overall ROP in subsequent wells on a pad.
Developmental potency of the murine allantois (1997)

The murine allantois is the future umbilical component of the placenta. The base of the allantois is also thought to contain the future germ line. We have examined the fate and developmental potency of cells within the murine allantois during gastrulation. lacZ-expressing headfold-stage allantoises (approximately 8.0 days postcoitum; dpc) were subdivided into three proximodistal regions and transplanted into three sites in synchronous non-transgenic host embryos: the primitive streak at the level of prospective paraxial mesoderm, the primitive streak at the level of lateral plate mesoderm, and the base of the allantois. After 23 hours in culture, operated conceptuses were examined histologically for contribution of donor allantoic cells to the conceptus. None of the allantoic regions contributed to paraxial mesoderm when placed into the fetus, but all three colonized the endothelium and adjacent mesenchyme of the dorsal aorta. The mid-region was most efficient at colonizing endothelium, whereas the base was the only allantoic region to exhibit relative pluripotency, colonizing several derivatives of all three primary germ layers. Differences in the state of differentiation along the proximodistal axis of the allantois were further borne out when the three allantoic regions were placed into the base of the allantois of host conceptuses. Striking differences were observed in final position along the proximodistal axis of the host allantois. Most grafted cells translocated distally from the base; however, basal donor allantoic cells translocated typically only as far as the host's mid-region, whereas donor allantoic tip cells typically returned to the tip, often colonizing the chorioallantoic fusion junction. Together, our data reveal that the headfold-stage allantois may contain a proximodistal gradient of differentiation, and raise intriguing questions about how this gradient was established and the role it plays in umbilical vasculogenesis.
Synthetic neural modeling applied to a real-world artifact. (1992)

We describe the general design, operating principles, and performance of a neurally organized, multiply adaptive device (NOMAD) under control of a nervous system simulated in a computer. The complete system, Darwin IV, is the latest in a series of models based on the theory of neuronal group selection, which postulates that adaptive behavior is the result of selection in somatic time among synaptic populations. The simulated brain of Darwin IV includes visual and motor areas that are connected with NOMAD by telemetry. Under suitable conditions, Darwin IV can be trained to track a light moving in a random path. After such training, it can approach colored blocks and collect them to a home position. Following a series of contacts with such blocks, value signals received through a "snout" that senses conductivity allow it to sort these blocks on the basis of differences in color associated with differences in their conductivity. Darwin IV represents a new approach to synthetic neural modeling (SNM), a technique in which large-scale computer simulations are employed to analyze the interactions among the nervous system, the phenotype, and the environment of a designed organism as behavior develops. Darwin IV retains the advantages of SNM while avoiding the difficulties and pitfalls of attempting to simulate a rich environment in addition to a brain.
Inflammatory Response in Microvascular Endothelium in Sepsis: Role of Oxidants (2008)

Sepsis, as a severe systemic inflammatory response to bacterial infection, represents a major clinical problem. It is characterized by the excessive production of reactive oxygen species (ROS) both in the circulation and in the affected organs. The excessive generation of ROS inevitably leads to oxidative stress in the microvasculature and has been implicated as a causative event in a number of pathologies including sepsis. In this review, we focus on the role of oxidative and nitrosative stress during the early onset of sepsis. Changes in microvascular endothelial cells, the cell type that occurs in all organs, are discussed. The mechanisms underlying septic induction of oxidative and nitrosative stresses, the functional consequences of these stresses, and potential adjunct therapies for microvascular dysfunction in sepsis are identified.
Photo-induced hybrid nanopatterning of titanium dioxide via direct imprint lithography (2010)

A novel ultraviolet (UV)-assisted imprinting procedure that employs photosensitive titanium(IV) di-n-butoxide bis(2-ethylhexanoate) is presented for the fabrication of well-ordered titanium dioxide (TiO2) nanostructures at room temperature. The main novelty of this technique is the use of the photosensitive titanium organic compound, rather than a commonly used UV-curable resin, for direct UV-assisted nanoimprint lithography. Fourier transform infrared and X-ray photoelectron spectroscopy studies suggest that exposure to UV light resulted in the gradual removal of organic groups from films prepared from titanium(IV) di-n-butoxide bis(2-ethylhexanoate) photochemically and successively converted the films to TiO2 at room temperature. This approach allows direct fabrication of TiO2 nanopatterns with lines down to 35 nm in width, hole arrays of 265 nm in diameter, and three-dimensional TiO2 hybrid micro/nano-patterns without observable defects for use in applications where ordered surface nanostructures are required, such as photovoltaics, photonics, and optical waveguides.
Laser-controlled local magnetic field using semiconductor quantum rings (2005)

We analize theoretically the dynamics of N electrons localized in a semiconductor quantum ring under a train of phase-locked infrared laser pulses. The pulse sequence is designed to control the total angular momentum of the electrons. The quantum ring can be put in states characterized by strong currents. The local magnetic field created by these currents can be used for a selective quantum control of single spins in semiconductor systems. PACS numbers: 73.23.Ra, 78.67.-n ∗Electronic address: pershin@pa.msu.edu
Cobalt−salen Intercalated Montmorillonite Catalyst for Air Oxidation of p-Cresol under Mild Conditions (2007)

Air oxidation of p-cresol under very mild conditions (338 K and ambient pressure) was carried out in a semibatch reactor over a solid catalyst developed by intercalating cobalt−salen into the montmorillonite clay. The intercalation of cobalt−salen was done by a simple protocol, and the characterization of the intercalated catalyst was done by XPS, FTIR, and XRD techniques. A total selectivity ≥90% to the oxidation products could be achieved with this solid catalyst by eliminating the undesired coupling side products in air oxidation of p-cresol under ambient pressure conditions. Effect of various process parameters on the conversion and selectivity pattern were also studied, and it was found that the selectivity ratio of aldehyde to alcohol could be varied by suitably changing the reaction conditions. This heterogeneous catalyst was found to give a 5-fold higher turnover number than the homogeneous cobalt−salen complex.
High power picosecond and nanosecond diode laser sources in the wavelength range 650 nm to 1100 nm (2015)

Optical pulses in the nanosecond and picosecond ranges can be generated by gain switching, Q-switching and mode-locking of diode lasers, either as stand-alone devices or in MOPA systems combining master oscillators (MOs) and power amplifiers (PAs). A review of recent progress achieved at FBH is presented. With a gain switched ridge waveguide (RW) laser optical pulses with a width of 1 ns and more than 5 nJ energy have been generated. Higher pulse peak powers up to 250 Watts (13 μJ) have been reached by gain switching a broad area laser with an in-house developed electronic circuit. Spectrally stable 5 ns long optical pulses with powers of 4 W and 16 W have generated with a RW amplifier and a tapered amplifier, respectively.
Immobilized enzyme-based flowing-stream analyzer for measurement of penicillin in fermentation broths (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTImmobilized enzyme-based flowing-stream analyzer for measurement of penicillin in fermentation brothsJ. F. Rusling, G. H. Luttrell, L. F. Cullen, and G. J. PaparielloCite this: Anal. Chem. 1976, 48, 8, 1211–1215Publication Date (Print):July 1, 1976Publication History Published online1 May 2002Published inissue 1 July 1976https://pubs.acs.org/doi/10.1021/ac50002a038https://doi.org/10.1021/ac50002a038research-articleACS PublicationsRequest reuse permissionsArticle Views87Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Random Access Preambles for Evolved UTRA Cellular System (2006)

The design of random access channel (RACH) preambles for the evolved universal terrestrial radio access (E-UTRA) third generation cellular system is considered, with the major goal to minimize the latency of RACH procedure. The E-UTRA RACH preambles are designed starting from a new construction of the sets of zero correlation zone (ZCZ) sequences, derived from the generalized chirp-like (GCL) sequences
Electroabsorption modulator integrated distributed feedback laser with a negative chirp at zero bias voltage (2002)

This paper describes high speed (16 GHz) DFB lasers integrated with electroabsorption modulators (EA-DFB lasers) having negative chirp characteristics. The EA-DFB laser exhibited negative-chirp at zero bias voltage by optimizing /spl kappa/L products and large electrical isolation resistance.
96-41: ICD efficacy in midseptal vs. apical RV lead positions. A subanalysis from the prospective randomized SPICE trial (2016)

Background: Right ventricular (RV) apical (A) pacing is known for its detrimental hemodynamic effects in implantable cardioverter defibrillators (ICD) recipients. The mid-septum (S) is suggested as an alternative pacing site. This intention to treat analysis compares ICD therapy efficacy for treatment of spontaneous sustained ventricular tachycardia (VT) with different RV lead positions Methods: ICD recipients were randomly assigned to receive ICD lead in a RV mid-septal or apical position. The patients were followed for one year. Stored spontaneous tachycardia electrograms were collected and classified by a blinded adjudication committee.
Low-frequency respiratory system resistance in the normal dog during mechanical ventilation (1991)

The low-frequency resistances of the respiratory system, lung, and chest wall were investigated in four anesthetized paralyzed dogs mechanically ventilated at various frequencies between 0.08 and 0.83 Hz. The resistances were calculated by three different methods: 1) as the real part of the complex impedance obtained from regular ventilation data, 2) as the effective resistance of a two-compartment model fitted to the same data, and 3) as the resistance of a single-compartment model fitted to data obtained during sinusoidal ventilation at various frequencies. Alveolar pressures were measured by a closed-chest alveolar capsule technique and afforded a direct measure of airways resistance. All three resistance estimates were very similar and decreased markedly with frequency between 0 and 1 Hz. The real part of lung impedance at the higher frequencies investigated (around 5 Hz) closely approximated airways resistance, as predicted by the eight-parameter viscoelastic model of respiratory mechanics proposed by Bates et al. (J. Appl. Physiol. 67:2276-2285, 1989).
Nuclear Quadrupole Resonances in Solid Bromine in Iodine Compounds (1954)

Pure quadrupole resonances of bromine or iodine nuclei have been observed in paradibromo- and paradiiodo-benzene; the tetrabromides of carbon, silicon, germanium and tin; germanium and tin tetraiodides; sodium, potassium, and cesium bromates; antimony tribromide and iodide; and cyanogen bromide. For most of these compounds, measurements were made at room temperature and at liquid nitrogen temperature. The results are correlated with chemical bonding and crystal structure data.
Experimental evaluation of collagen sponge as a dural graft (1993)

Early collagen products, when used as dural substitutes, promoted severe inflammatory responses and fell into disrepute. A more recent advance, collagen sponge, which is derived from bovine flexor tendons was used in this experimental study. Collagen sponge was surgically implanted as an onlay dural replacement graft following skull trephination and dural excision in 12 primates. Macroscopic, histological and electron-microscopical evaluations were performed at periods of 1, 3 and 9 months. This preliminary animal study indicated that collagen sponge is suitable to use as a graft since it does not induce any inflammatory response or adhesions in the absence of pia arachnoid injury. If forms an ideal scaffold for the early ingrowth of fibroblasts to effect dural repair.