gebhart/patrepeval huggingface dataset:
Data from Antitumor Effects of a Combined 5-Aza-2′Deoxycytidine and Valproic Acid Treatment on Rhabdomyosarcoma and Medulloblastoma in <i>Ptch</i> Mutant Mice (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;i&gt;Patched&lt;/i&gt; (&lt;i&gt;Ptch&lt;/i&gt;) heterozygous mice develop medulloblastoma (MB) and rhabdomyosarcoma (RMS) resembling the corresponding human tumors. We have previously shown that epigenetic silencing of the intact &lt;i&gt;Ptch&lt;/i&gt; allele contributes to tumor formation in this model. Here, we investigated whether targeting of epigenetic silencing mechanisms could be useful in the treatment of &lt;i&gt;Ptch&lt;/i&gt;-associated cancers. A reduction of endogenous DNA methyltransferase1 (Dnmt1) activity significantly reduced tumor incidence in heterozygous &lt;i&gt;Ptch&lt;/i&gt; knockout mice. A combined treatment with the Dnmt inhibitor 5-aza-2′deoxycytidine (5-aza-dC) and the histone deacetlyase (HDAC) inhibitor valproic acid (VPA) efficiently prevented MB and RMS formation, whereas monotherapies with either drug were less effective. Wild-type &lt;i&gt;Ptch&lt;/i&gt; expression was efficiently reactivated in tumors by 5-aza-dC/VPA combination therapy. This was associated with reduced methylation of the &lt;i&gt;Ptch&lt;/i&gt; promoter and induction of histone hyperacetylation suggesting inhibition of HDACs &lt;i&gt;in vivo&lt;/i&gt;. However, the treatment was not effective in clinically overt, advanced stage tumors. This is a first &lt;i&gt;in vivo&lt;/i&gt; demonstration that targeting of Dnmt and HDAC activities is highly effective in preventing formation of &lt;i&gt;Ptch&lt;/i&gt;-associated tumors. The results suggest a novel clinical strategy for consolidation therapy of corresponding tumors in humans after completion of conventional treatment. Our data also suggest that epigenetic therapy may be less effective in treating advanced stages of tumors, at least in this tumor model. [Cancer Res 2009;69(3):887–95]&lt;/p&gt;&lt;/div&gt;
Regulation of Neuronal Circuits and Animal Behavior by Metabotropic Glutamate Receptors (1994)

Within the nervous system, neurons are organized into circuits or networks of interconnected cells that mediate specific functional tasks. Traditionally, most of the major connections that make up a neural network have been viewed as synaptic connections in which activation of ligand-gated ion channels results in either excitation or inhibition of a receptive neuron (i.e., fast synaptic transmission). However, in recent years, the increase in our understanding of second messengers and their roles in modulating neuronal excitability and synaptic transmission has led to an enlargement of this concept. It is now clear that fast synaptic transmission through networks of neurons can be modulated by activation of receptors coupled to second-messenger systems through GTP-binding proteins. For instance, in a network of neurons connected by glutamatergic synapses, it was generally held that glutamate would elicit fast synaptic responses by activating members of the ionotropic glutamate receptor family. Neuromodulators from extrinsic afferents (i.e., acetylcholine, serotonin, norepinephrine, and so forth) could then modulate transmission through the network of glutamatergic neurons by activating GTP-binding protein-linked receptors and second-messenger systems. Although there are a number of neurotransmitters that activate both ligand-gated ion channels and receptors coupled to second-messenger systems, until recently, it was thought that all of the actions of glutamate, the major excitatory neurotransmitter in the brain, were mediated by activation of ionotropic glutamate receptors and generation of fast synaptic responses.
Dissolution of Trapped Nonaqueous Phase Liquids: Mass Transfer Characteristics (1990)

Many groundwater contamination incidents begin with the release of an essentially immiscible fluid into the subsurface environment. Once in the subsurface, an immiscible fluid participates in a complex pattern of transport processes. For immiscible fluids that are commonly found in contaminated groundwater environments the interphase mass transfer between the nonaqueous phase liquids (NAPLs) phase and the aqueous phase is an important process. An experimental apparatus and procedure were used to isolate and measure mass transfer between toluene and water in glass bead media systems. The rate of interphase mass transfer was investigated in two‐fluid systems as a function of aqueous phase velocity, aqueous‐ and nonaqueous‐phase fluid saturations, and porous media characteristics. The rate of interphase mass transfer is found to be directly related to aqueous phase velocity and nonaqueous phase fluid saturation level, but no significant relation to mean particle size is found. Correlation expressions for the rate of interphase mass transfer are developed using relevant dimensionless parameters and are compared to literature values. Equilibrium between the two fluid phases investigated is shown to be achieved rapidly, over wide ranges of nonaqueous phase fluid saturations and aqueous phase velocities. The derived correlations provide a means for estimating the appropriateness of the local equilibrium assumption for a nonaqueous phase liquid‐aqueous phase couple in multiphase groundwater systems.
Vapor-liquid equilibriums by UNIFAC group contribution. Revision and extension. 2 (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVapor-liquid equilibriums by UNIFAC group contribution. Revision and extension. 2Juergen Gmehling, Peter Rasmussen, and Aage FredenslundCite this: Ind. Eng. Chem. Process Des. Dev. 1982, 21, 1, 118–127Publication Date (Print):January 1, 1982Publication History Published online1 May 2002Published inissue 1 January 1982https://pubs.acs.org/doi/10.1021/i200016a021https://doi.org/10.1021/i200016a021research-articleACS PublicationsRequest reuse permissionsArticle Views2217Altmetric-Citations466LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Effect of soil salinity on entomopathogenic nematode survival and behaviour (2011)

Abstract Soil salinity, measured as electroconductivity (dS m –1 ), is a major problem in crop production, including areas where entomopathogenic nematodes (EPN) are applied as biological control agents. EPN species, primarily Heterorhabditis , have been isolated from coastal areas and agricultural soils with high salinity ( &gt; 4.0 dS m –1 ). Given the aqueous nature of their environment, soil salinity may play an important role in EPN movement and host finding. We assessed the survival of Steinernema riobrave , S. glaseri , Heterorhabditis indica , H. sonorensis and H. bacteriophora exposed to saline soils within the range found in agricultural soils. Survival and infectivity were generally unaffected by salinities ranging from 0 to 50 dS m –1 (50 dS m –1 is similar to the salinity of seawater). Salinity had been shown to negatively impact foraging in S. riobrave so additional experiments analysing the behaviour and attraction to host cues by S. riobrave and H. indica were conducted. Agar-based behavioural assays revealed species-specific responses to salinity. At the higher salinity levels (30 and 50 dS m –1 ) movement of H. indica decreased, the path taken was more circuitous and individuals did not move toward a host. There was a strong antagonistic effect on H. indica motility and host-finding behaviour. No significant differences were observed for S. riobrave exposed to any of these salinity levels. However, under simulated field conditions, high saline conditions (30 and 50 dS m –1 ) reduced the distance both H. indica and S. riobrave travelled toward a host. Both species are used for biological control of weevil pests in orchards where salinities have been recorded up to 20 dS m –1 . Field efficacy of EPN applied for biological control in saline soils may be improved by timing applications to avoid late season build-up of salts in irrigated crops and applying the appropriate EPN species.
Keratoderma-like T cell dyscrasia: A report of 13 cases and its distinction from mycosis fungoides palmaris et plantaris (2016)

The spectrum of cutaneous lymphoid dyscrasias should be expanded to include cases manifesting as palmo-plantar keratoderma. These cases are to be distinguished from mycosis fungoides palmaris et plantaris. As with other forms of cutaneous lymphoid dyscrasia, the lesions tend to be persistent. The course however, is indolent in most cases.
Impact of Collagen Crosslinking on Dislocated Human Shoulder Capsules—Effect on Structural and Mechanical Properties (2022)

Classical treatments of shoulder instability are associated with recurrence. To determine whether the modification of the capsule properties may be an alternative procedure, the effect of crosslinking treatment on the structure and mechanical properties of diseased human shoulder capsules was investigated. Joint capsules harvested from patients during shoulder surgery (n = 5) were treated or not with UV and/or riboflavin (0.1%, 1.0% and 2.5%). The structure and the mechanical properties of the capsules were determined by atomic force microscopy. The effect of treatments on cell death was investigated. Collagen fibrils were well-aligned and adjacent to each other with a D-periodicity of 66.9 ± 3.2 nm and a diameter of 71.8 ± 15.4 nm in control untreated capsules. No effect of treatments was observed on the organization of the collagen fibrils nor on their intrinsic characteristics, including D-periodicity or their mean diameter. The treatments also did not induce cell death. In contrast, UV + 2.5% riboflavin induced capsule stiffness, as revealed by the increased Young's modulus values (<i>p</i> < 0.0001 for each patient). Our results showed that the crosslinking procedure changed the biomechanics of diseased capsules, while keeping their structural organisation unchanged at the single fibril level. The UV/riboflavin crosslinking procedure may be a promising way to preserve the functions of collagen-based tissues and tune their elasticity for clinically relevant treatments.
VHDL-based communication and synchronization synthesis (1995)

This paper describes an approach for VHDL-based communication and synchronization synthesis. This design step transforms a system level VHDL description into an RT-level description. The idea is, not to synthesize system level implementations of communication, and synchronization mechanisms but to perform the synthesis step as a mapping step of an abstract communication or synchronization mechanism to one of a set of RT-level implementations. The major sub-problem, which needed to be solved for the synthesis algorithm was the topology dependent mapping of implementations.
Building Hypertext on a Multimedia Toolkit: An Overview of Andrew Toolkit Hypermedia Facilities. (1990)

This paper discusses several hypermedia facilities built on top of the Andrew Toolkit (ATK) and their use in ATK applications. As a general-purpose, multimedia, application-development system, ATK permits many kinds of links, references and other connections to be made within pieces of content and between pieces of content, regardless of the content&amp;apos;s medium. We argue that starting with a multimedia architecture facilitates the construction of all forms of hypermedia. Four specific hypermedia facilities implemented with ATK are discussed: an integrated web and indexing system (Help), a simple multimedia link facility (Link), a cross reference (Textref) capability, and a linksupporting embedded object language (Ness). As a toolkit, ATK is used to build other applications which inherit ATK&amp;apos;s hypermedia facilities. Therefore we consider briefly the way that hypermedia facilities are used in conventional applications, such as mail systems.
Scalability of DVB-H Deployment on Existing Wireless Infrastructure (2006)

This article investigates the scalability of DVB-H deployment on existing wireless infrastructure for digital broadcasting and cellular networks. Three deployment strategies are investigated: when only the broadcasting and the cellular infrastructure are used separately, and the case when both can be used jointly. The outcomes show that, in general, the investment needed for increasing the service capacity by switching to higher order modulation, or for increasing the coverage level over a given service area, lead to a higher annualized cost per Mb/s
Neutron-Capture Cross Section of 35-h Rh105 (1964)

AbstractThe cross section for the reaction 35-h Rh105 (n,γ)30-sec Rh106 has been measured using a TRIGA reactor in the pulsed mode of operation as a neutron source. The effective thermal-neutron (0 to 0.5 eV) cross section was found to be 13 300 ± 1 500 b, relative to a 36-b cross section for Co59. The cadmium ratio was observed to be ≥ 20 in a neutron flux for which a cadmium ratio of 7 was measured for cobalt. Notes* This work was supported by the USAEC and by private funds of General Dynamics Corporation.
Mesoporous ZnCo2O4 nanoflakes grown on nickel foam as electrodes for high performance supercapacitors (2015)

ZnCo2O4 nanoflakes, as electrodes for supercapacitors, are grown on a cellular nickel foam using a cost-effective hydrothermal procedure. The mesoporous ZnCo2O4 nanoflakes have large electroactive surface areas with strong adhesion to the Ni foam, allowing fast ion and electron transport. The nanoarchitecture electrodes deliver an excellent specific capacitance of 1220 F g(-1) at a current density of 2 A g(-1) in a 2 M KOH aqueous solution and a long-term cyclic stability of 94.2% capacitance retention after 5000 cycles. The fabrication strategy is facile, cost-effective, and can offer great promise for large-scale supercapacitor applications.
New method to control composition ratio of alloy films by compressed magnetic field–magnetron sputtering technique (1987)

We propose a new method to control a composition ratio of Si to refractory metal by a compressed magnetic field–magnetron sputtering source. This magnetron sputtering source has two magnetic coils, one is a conventional magnetron coil behind the target (Bm) and the other is a compressing coil (Bc) to increase magnetic field parallel to the target surface. The Bm and Bc can control the spatial position of intense plasma on the target surface. Experiments were performed using a 98-mm Si target with an additional ring-shaped Ta target, which has 98-mm outer diameter and 5-mm width. The Si/Ta ratio of sputtered films was controlled from 1 to 10 only by changing Bc from 108 to 197 G for constant Bm (=630 G).
A new non-muscle-invasive bladder tumor-homing peptide identified by phage display in vivo (2016)

Bladder cancer is common and widespread, and its incidence is increasing. Many new diagnostic methods combined with state-of-the-art technology have been introduced in cystoscopy to collect real-time images of the bladder mucosa for diagnosis, but often miss inconspicuous early-stage tumors. Fluorophore-labeled peptides with high sensitivity and specificity for cancer would be a desirable tool for the detection and treatment of tiny or residual bladder tumors. Phage display and the human non-muscle-invasive bladder cancer cell line BIU-87 were used to identify a peptide. The isolated phage display peptide (CSSPIGRHC, named NYZL1) was tested in vitro for its binding specificity and affinity. Accumulation into xenograft tumors in a nude mouse model was analyzed with FITC-labeled NYZL1. NYZL1, with strong tumor‑homing ability, was identified by in vivo phage library selection in the bladder cancer model. The NYZL1 phage and synthetic FITC-labeled NYZL1 peptides bound to tumor tissues and cells, but were hardly detected in normal control organs. Notably, accumulation of FITC-NYZL1 in bladder tumor cells was time-dependent. Biodistribution studies of xenografts of BIU-87 cells showed accumulation of injected FITC-NYZL1 in the tumors, and the bound peptide could not be removed by perfusion after 24 h. The mouse model of bladder tumor showed increased fluorescence intensity in the tumor-bearing bladder in comparison with normal bladder tissues after 4-6 h. In conclusion, NYZL1 may represent a lead peptide structure applicable in the development of optical molecular imaging.
A test automation solution on GUI functional test (2008)

Although it is widely believed that software quality will be improved by the use of automated testing, automation is still not well-off in industry today. There are quite a few issues of traditional software test automation mode, for example, high cost, knowledge barriers, and management troubles. In the paper, a test automation solution on GUI functional test is proposed. The solution integrates test case generation and selection, test case execution, and test reporting to facilitate testing. It introduces the concept of test driver which is designed to take over the communication between test cases and the execution engine. At last, some enhancements are proposed for future work.
A 5-HT4-receptor activation-induced neural plasticity enhances in vivo reconstructs of enteric nerve circuit insult (2010)

These results indicate that activation of enteric neural 5-HT(4)-receptors promotes reconstruction of an enteric neural circuit leading to the recovery of the defecation reflex in the distal gut, and that this reconstruction involves possibly neural stem cells. These findings indicate that treatment with 5-HT(4) agonists could be a novel therapy for generating new enteric neurons to rescue aganglionic gut disorders.
Distributed Media Rate Allocation in Overlay Networks (2006)

We address the problem of distributed path selection and rate allocation for media streaming in overlay networks. Under the assumption that each node has only a local view of the network, we propose a distributed algorithm for joint path selection, and rate allocation, in order to minimize the end-to-end media distortion. The distributed algorithm performs iteratively, by greedy rate allocation for all incoming media flows on the outgoing links at each intermediate node. Our algorithm is shown to converge to the optimal rate allocation solution in a very small number of iterations, and to outperform heuristic distributed rate allocation mechanisms for a number of random network topologies
Algorithm-enabled single-kVp-switch scan configuration for dual-energy CT (2017)

In dual-energy CT, material-basis and/or monochromatic-energy images are reconstructed from data sets collected with two different spectra. Among the four existing methods for realizing dual-energy imaging in diagnostic CT, three of them require hardware addition or modification to a regular diagnostic CT scanner, in order to acquire the dual-energy data sets with two different spectra. We investigate a new single-kVp-switch method for achieving flexible dual-energy imaging on current CT systems without invoking hardware addition or modification to existing CT scanners. The method is enabled by a one-step algorithm that is based on the non-linear data model. Physical phantom data from a diagnostic CT scanner were collected and reconstructed from. Images results and profile plots from the proposed half-plus-half scan configuration were compared to those from the standard full-plus-full scan. Visual resemblance and quantitative agreement were observed, suggesting potential possibilities of enabling flexible dual-energy CT imaging with regular CT scanners without hardware addition or modification.
Production of Inorganic thin Scintillating Films for Ion Beam Monitoring Devices (2006)

In this work we present the development of beam monitoring devices consisting of thin CsI(Tl) films deposited on Aluminium support layers. The light emitted by the scintillating layer during the beam irradiation is measured by a CCD-camera. In a first prototype a thin Aluminium support layer of 6 micron allows the ion beam to easily pass through without significant energy loss and scattering effects. Therefore it turns out to be a non-destructive monitoring device to characterize on-line beam shape and beam position without interfering with the rest of the irradiation process. A second device consists of an Aluminium support layer which is thick enough to completely stop the impinging ions allowing to monitor at the same time the beam profile and the beam current intensity. Some samples have been coated by a 100 Å protective layer to prevent the film damage by atmosphere exposition. In this contribution we present our experimental results obtained by irradiating the samples with proton beams at 8.3 and 62 MeV. We also propose some innovative applications of these beam monitoring devices in different nuclear sectors such as cancer proton therapy and high intensity beam accelerators.
Erratum: High resolution 1H solid state NMR studies of polyethyleneterephthalate [J. Chem. Phys. 7 3, 6059 (1980)] (1981)

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Exploring feedback‐controlled versus open‐circuit electrochemical lipolysis in ex vivo and in vivo porcine fat: A feasibility study (2021)

V-ECLL and P-ECLL at the aforementioned dosimetry parameters both achieved fat necrosis by adipocyte membrane lysis and denuclearization. The -2.5 V and -3.5 V P-ECLL treatments created spatially similar fat necrotic effects when compared to the 5 V V-ECLL treatment. Quantitatively, total charge transfer between dosimetry parameters suggests that -2.5 V P-ECLL and 5 V V-ECLL produce comparable electrochemical reactions. Such findings suggest that a low-voltage closed-loop potentiostat-based system is capable of inducing fat necrosis to a similar extent compared to that of a higher voltage direct current system.
Клеточные белки Ku и HMGA1 как участники транскрипции ВИЧ-1 (2016)

Вирус иммунодефицита человека первого типа (ВИЧ-1) использует транскрипционную машину клетки-хозяина для транскрипции своих генов. Единственным вирусным белком, участвующим в этом процессе, является трансактиватор транскрипции Tat. В острой фазе инфекции Tat связывается с РНК шпилькой в начале транскрибируемой вирусной РНК и привлекает комплекс P-TEFb, который гиперфосфорилирует РНК-полимеразу II и запускает элонгацию транскрипции. Латентная фаза ВИЧ-инфекции характеризуется низким уровнем транскрипции. В латентной фазе и при выходе из нее белок Tat в клетке не детектируется, и механизм активации транскрипции в его отсутствие понятен не до конца. Актуальным остается вопрос о механизме поддержания латентности. Очевидно, что и в репрессии транскрипции в латентной фазе, и в ее активации при переходе в литическую фазу инфекции участвуют клеточные белки, роль которых еще не выяснена. Данный обзор посвящен обсуждению роли клеточных белков Ku и HMGA1 в инициации и элонгации транскрипции интегрированного генома ВИЧ-1. Представлены данные о зависи мости Ku-опосредованной транскрипции ВИЧ-1 от структуры промотора и формы вирусной ДНК. Описано разнонаправленное влияние белка HMGA1 на индуцируемую транскрипцию и на базальную транскрипцию ВИЧ-1. Предложены возможные механизмы участия белков Ku и HMGA1 в регуляции транскрипции про вируса.