gebhart/patrepeval huggingface dataset:
cDNA Cloning of Myosin Heavy Chain Isoforms From Carp Fast Skeletal Muscle and Their Gene Expression Associated With Temperature Acclimation (1997)

We have isolated cDNA clones encoding fast skeletal muscle myosin heavy chains of carp acclimated to 10, 20 and 30 degrees C for over 5 weeks. All clones covered at least the full length of L-meromyosin, the C-terminal part of the myosin molecule. Nucleotide sequence analysis on cDNA clones showed three types of 3' untranslated sequences, demonstrating that carp expresses at least three myosin heavy chain isoforms in fast skeletal muscle in an acclimation-temperature-dependent manner. cDNAs were identified which were the predominant types expressed in 10 degrees C- and 30 degrees C-acclimated fish, as well as an intermediate type present at all acclimation temperatures. Northern blot analysis using probes of three kinds of DNA fragments from the 3' untranslated region of carp acclimated to 10, 20 and 30 degrees C further confirmed the presence of acclimation-temperature-specific isoforms. In addition, it was found that mRNA levels of three isoforms were altered in an acclimation-temperature-dependent manner. When the deduced amino acid sequences of three types of carp L-meromyosin were compared with those of homoiotherms, the 30 degrees C-acclimated type was more similar to those of homoiotherms than was the 10 degrees C-acclimated type.
The Effects of Tiamulin, a Semisynthetic Pleuromutilin Derivative, on Bacterial Polypeptide Chain Initiation (1978)

Tiamulin, a water-soluble and highly effective semisynthetic derivative of pleuromutilin leads to the formation of physiologically inactive polypeptide chain initiation complexes which readily decompose and do not enter the phase of peptide chain elongation. Once elongation has begun it continues even in the presence of tiamulin as has been shown by measuring the formation of N-acetylphenylalanine-poly(phenylalanine). The formation of abortive initiation complexes was observed regardless of whether AcPhe-tRNA of fMet-tRNA was used as an initiator or whether artificial messengers or a natural messenger, like R17 bacteriophage RNA, was used. When this drug was acting on whole cells, it led to the disappearance of polysomes. The only structures which could be detected were of the monosome size. Therefore, polysomes seem to elongate the polypeptide chains in whole cells in the presence of this antibiotic, but since effective reinitiation is blocked, the polysome pool of the cell soon becomes depleted.
Phase-Weighted Stacking Applied to Low-Frequency Earthquakes (2014)

Abstract We apply phase‐weighted stacking (PWS) to the analysis of low‐frequency earthquakes (LFEs) in the Parkfield, California, region and central Cascadia. The technique uses the coherence of the instantaneous phase among the stacked signals to enhance the signal‐to‐noise ratio (SNR) of the stack. We find that for picking LFE arrivals for the Parkfield, California, region and for LFE template formation in central Cascadia, PWS is extremely effective. For LFEs in the Parkfield, California, region, PWS yields many more usable phases than standard linear stacking; and, for LFE detection in Cascadia, PWS produces templates with much higher SNR than linear stacking.
Information content inF(R)brane models with nonconstant curvature (2015)

In this work we investigate the entropic information measure in the context of braneworlds with nonconstant curvature. The braneworld entropic information is studied for gravity modified by the square of the Ricci scalar, besides the usual Einstein-Hilbert term. We showed that the minimum value of the brane configurational entropy provides a stricter bound on the parameter that is responsible for the $F(R)$ model differing from the Einstein-Hilbert standard one. Our results are moreover consistent to a negative bulk cosmological constant.
Molecular Analysis of T-Cell Repertoire in Patients with Graft-Versus-Host Disease after Allogeneic Stem Cell Transplantation (2003)

Complementarity-determining region (CDR3) size spectratyping has often been used to analyze the clonal expansion of T-cells. CDR3 size spectratyping has been useful in the analysis of the oligoclonal expansion of T-cells in virus infection, graft-versus-leukemia effect (GVL), graft-versus-host disease (GVHD), and immune reconstitution of T-cells after allogeneic stem cell transplantation (allo-SCT). We analyzed 26 T cell receptor (TCR)-beta-chain subfamilies (VB) in 25 patients who underwent allo-SCT. Fifteen of these patients developed acute GVHD (aGVHD). Many TCR-VB were skewed in the early stage. In these TCR-VB subfamilies, VB6 was most often skewed at the time of skin aGVHD. We then analyzed the average score of the complexity of 26 TCR-VB spectratypings in patients with or without cGVHD. The patients who developed chronic GVHD (cGVHD) had a lower average score of TCR-VB complexity than that of patients without cGVHD (P = 0.010). In particular. the patients who developed the quiescent type and de novo type of cGVHD from 4 months after allo- SCT had a lower average score of TCR-VB complexity at 3 months than that of the patients who had no cGVHD (P = 0.0055). These results suggest that we might be able to consider a possible development of cGVHD by analyzing TCR-VB spectratyping after allo-SCT.
Temperature-Induced Uncertainty of the Effective Fracture Pressures: Assessment and Control (2014)

Abstract The constant bottom-hole pressure (CBHP) method of managed pressure drilling (MPD) maintains wellbore pressure above the wellbore stability or pore pressure and below the fracture pressure. It is common practice to perform frequent dynamic formation integrity/leakoff tests (FIT/LOT) to measure the fracture pressure. Several authors addressed the uncertainty in the measured value of the fracture pressure caused by mud compressibility and thixotropy. Moreover, field evidence indicates considerable variations in the effective fracture pressures resulting from varying wellbore temperatures. This paper presents a mathematical model, validated with field data, to estimate the effective fracture pressure (EFP) from the leakoff test data. The model accounts for the effect of mud compressibility and thixotropy, and considers the effect of transient wellbore temperatures on the geomechanical rock stresses. The study also presents application of quantitative risk assessment (QRA) to represent the probability density distribution of EFP associated with the uncertainties in the input paramaters. The method was demonstrated with two examples from the Gulf of Mexico. The study shows that the operational parameter–"pumps off" time, and two formation properties-Young's modulus of elasticity (E) and thermal expansion coefficient (αT) contribute most to the uncertainty in EFP. Moreover, a log-normal distribution of the EFP indicated a strong effect of temperature variation. It is also concluded that the uncertainty resulting from the temperature effect could be minimized by conducting the test after a characteristic 60-minutes pumps-off period.
Serum Adiponectin Is Reduced in Acromegaly and Normalized after Correction of Growth Hormone Excess (2004)

Adiponectin, an adipocyte-derived hormone, possesses insulin-sensitizing, antiinflammatory, and antiatherogenic properties. We hypothesized that hypoadiponectinemia was present in acromegaly, as in other conditions with increased insulin resistance and cardiovascular risk. Using an in-house RIA, serum adiponectin was determined in 35 patients with active acromegaly and 35 age-, sex-, and body mass index-matched healthy controls. Twenty-five patients were restudied after GH-lowering therapies. Serum adiponectin was significantly reduced in the acromegalic patients (4.3 +/- 1.8 vs. 6.7 +/- 1.8 microg/ml in controls; P < 0.001), but was increased after treatment with Sandostatin LAR, a long-acting somatostatin analog (5.8 +/- 2.6 vs. 3.8 +/- 1.6 microg/ml pretreatment; P < 0.001; n = 15) or transsphenoidal surgery (6.5 +/- 2.7 vs. 3.9 +/- 1.5 microg/ml preoperation; P < 0.01; n = 10). Fasting insulin was an independent determinant of serum adiponectin levels (P < 0.01) in control subjects, contributing to 11.7% of the variance in circulating adiponectin. In cultured 3T3-L1 adipocytes, adiponectin mRNA levels were decreased by insulin (1.5 microm; P < 0.005) or IGF-I (1 microg/ml; P < 0.05), but not by GH (1 microm) or somatostatin (1 microm). In conclusion, hypoadiponectinemia is present in active acromegaly, probably secondary to the inhibitory effect of high circulating insulin levels. Hypoadiponectinemia, reversible with GH-lowering therapies, may contribute to the increased insulin resistance and cardiovascular risk in patients with acromegaly.
“Best Practice” for Patient-Centered Communication: A Narrative Review (2013)

Evidence supports the importance of communication skills as a dimension of physician competence. Effort to enhance teaching of communication skills to medical trainees likely will require significant changes in instruction at undergraduate and graduate levels, as well as changes in assessing the developing communication skills of physicians. An added critical dimension is faculty understanding of the importance of communication skills, and their commitment to helping trainees develop those skills.
H3.3-G34R Mutation-Mediated Epigenetic Reprogramming Leads to Enhanced Efficacy of Immune Stimulatory Gene Therapy in Diffuse Hemispheric Gliomas (2023)

This study uncovers the role of the H3.3-G34 mutation in reprogramming the tumor immune microenvironment in diffuse hemispheric gliomas. Our findings support the implementation of precision medicine informed immunotherapies, aiming at improving enhanced therapeutic outcomes in adolescents and young adults harboring H3.3-G34 mutant DHGs.
The 2016 Visualization Technical Achievement Award (2016)

The 2016 Visualization Technical Achievement Award goes to David Ebert in recognition of foundational work in visual analytics, both through development of fundamental predictive techniques and as Director of the Purdue/DHS Visual Analytics Center of Excellence.
Investigation of Fission Layers for Precise Fission Cross-Section Measurements with a Gridded Ionization Chamber (1984)

An ionization chamber with a Frisch grid is used to determine both the energy (E) of the charged particles emitted from the source positioned coplanar with the cathode, and the cosine of the emission angle (ϑ) with respect to the normal of the cathode. In the plane determined by the variables cosϑ and E, it is possible to identify an area that is unaffected by backscattering and self-absorption. Events belonging to this area show an isotropic angular distribution for alpha particles and also for fragments of fission induced by thermal neutrons, which, extrapolated to 90 deg, yields the absolute number of events.The capabilities of this technique are demonstrated by the investigation of four evaporated 235UF4 layers and one suspension-sprayed 235U3O8 layer. For the UF4 layers, the alpha-particle source strengths were determined, and agreement was found within 0.3% with values independently measured by low-geometry alpha counting.The same method was also applied to fission events induced by thermal neutrons. The determination of the total number of fission events is determined to an accuracy of better than 0.5%. The longstanding doubts on the magnitudes of fragment absorption and scattering are, in principle, circumvented by the present method, and therefore no assumptions on fragment ranges and scattering cross sections are needed. It is emphasized that the present method, within reasonable limits, is insensitive to source shape and homogeneity in its thickness.
Heat and mass transfer in calcination of limestone particles (2011)

Abstract The heat and mass‐transfer phenomena occurring during the calcination of limestone particles was studied by means of modeling. The applicability of two modeling methods for calcination was compared under different conditions. An unsteady numerical particle model with mass, momentum, energy balance, and shrinking core models were chosen for the study. The influence of different phenomena (chemical kinetics, advective and diffusive mass transfer, and heat transfer) in different conditions was evaluated with the aid of dimensionless parameters, and their relative importance was shown in a regime chart. Especially, the significance of advection was studied and its importance in high CO 2 concentration was observed. Local temperatures inside the particle were obtained by solving a dynamic energy balance in each particle layer including calcination reaction energy and conduction heat transfer. Noticeable temperature differences between constant ambient conditions and the particle were observed. © 2011 American Institute of Chemical Engineers AIChE J, 58: 2563–2572, 2012
SAFETY ASSESSMENT OF HIGHWAY DESIGNS (1991)

One of the primary purposes for redesigning a roadway segment is to improve safety. In the U.S., the Federal Highway Administration (FHWA) plans to require all states to implement safety management plans within the next several years. The primary objectives of a safety management plan are to identify and prioritize hazardous roadway locations and features. Although these objectives are easily stated they are difficult to achieve because there is no commonnly accepted technique for quantifying safety. This paper describes a systematic technique for quantifying safety that can be used to identify, prioritize and compare hazardous locations. An object oriented software technique for implementing this technique is then described in later sections.
Atomistic protein folding simulations on the submillisecond time scale using worldwide distributed computing (2002)

Atomistic simulations of protein folding have the potential to be a great complement to experimental studies, but have been severely limited by the time scales accessible with current computer hardware and algorithms. By employing a worldwide distributed computing network of tens of thousands of PCs and algorithms designed to efficiently utilize this new many-processor, highly heterogeneous, loosely coupled distributed computing paradigm, we have been able to simulate hundreds of microseconds of atomistic molecular dynamics. This has allowed us to directly simulate the folding mechanism and to accurately predict the folding rate of several fast-folding proteins and polymers, including a nonbiological helix, polypeptide alpha-helices, a beta-hairpin, and a three-helix bundle protein from the villin headpiece. Our results demonstrate that one can reach the time scales needed to simulate fast folding using distributed computing, and that potential sets used to describe interatomic interactions are sufficiently accurate to reach the folded state with experimentally validated rates, at least for small proteins.
Comparative Molecular Field Analysis of Haptens Docked to the Multispecific Antibody IgE(Lb4) (1996)

Using comparative molecular field analysis (CoMFA), three-dimensional quantitative structure-activity relationships were developed for 27 haptens which bind to the monoclonal antibody IgE(Lb4). In order to obtain an alignment for these structurally very diverse antigens, the compounds were docked to a previously modeled receptor structure using the automated docking program AUTODOCK (Goodsell, D.S.; Olson, A.J. Proteins: Struct., Funct., Genet. 1990, 8, 195-202). Remarkably, this alignment method yielded highly consistent QSAR models, as indicated by the corresponding cross-validated r2 values (0.809 for a model with carbon as probe atom, 0.773 for a model with hydrogen as probe atom). Conventional alignment failed in providing a basis for self-consistent CoMFAs. Amino acids Tyr H 50, Tyr H 52, and Trp H 95 of the receptor appeared to be of crucial importance for binding of various antigens. These findings are consistent with earlier considerations of aromatic residues being responsible for the multispecificity of certain immunoglobulins.
Surface modifications of poly(ether ether ketone) (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSurface modifications of poly(ether ether ketone)Nicole L. Franchina and Thomas J. McCarthyCite this: Macromolecules 1991, 24, 11, 3045–3049Publication Date (Print):May 1, 1991Publication History Published online1 May 2002Published inissue 1 May 1991https://pubs.acs.org/doi/10.1021/ma00011a003https://doi.org/10.1021/ma00011a003research-articleACS PublicationsRequest reuse permissionsArticle Views1071Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
High contrast waveguide devices (2002)

Silica-on-Si waveguides with a higher core-to-cladding index contrast can provide high-density and low-cost optical devices for photonic networks. This paper reviews recent progress on these devices focusing on arrayed waveguide gratings (AWGs) and lattice-type filters.
Einleitung (1973)

Als Fertigungsverfahren zur Oberflächenbehandlung ist die Spritztechnik, sowohl für die Instandsetzung als auch für die Neuanfertigung von Maschinenteilen und Werkzeugen, wichtig und unentbehrlich geworden. Die Anforderungen, die zum Schutz metallischer Oberflächen an Spritzschichten gestellt werden, sind Verschleißfestigkeit, Thermoschockbeständigkeit, Korrosionsbeständigkeit, Wärmedämmung und elektrische Isolationsfähigkeit. Als Überzug mit porösem Aufbau werden Spritzschichten ferner zur Verbesserung von Lager-Laufeigenschaften eingesetzt.
Sphingoid Base Is Required for Translation Initiation during Heat Stress inSaccharomyces cerevisiae (2005)

Sphingolipids are required for many cellular functions including response to heat shock. We analyzed the yeast lcb1-100 mutant, which is conditionally impaired in the first step of sphingolipid biosynthesis and shows a strong decrease in heat shock protein synthesis and viability. Transcription and nuclear export of heat shock protein mRNAs is not affected. However, lcb1-100 cells exhibited a strong decrease in protein synthesis caused by a defect in translation initiation under heat stress conditions. The essential lipid is sphingoid base, not ceramide or sphingoid base phosphates. Deletion of the eIF4E-binding protein Eap1p in lcb-100 cells restored translation of heat shock proteins and increased viability. The translation defect during heat stress in lcb1-100 was due at least partially to a reduced function of the sphingoid base-activated PKH1/2 protein kinases. In addition, depletion of the translation initiation factor eIF4G was observed in lcb1-100 cells and ubiquitin overexpression allowed partial recovery of translation after heat stress. Taken together, we have shown a requirement for sphingoid bases during the recovery from heat shock and suggest that this reflects a direct lipid-dependent signal to the cap-dependent translation initiation apparatus.
A CMOS Low-Dropout Regulator With Dominant-Pole Substitution (2015)

A dominant-pole substitution (DPS) technique for low-dropout regulator (LDO) is proposed in this paper. The DPS technique involves signal-current feedforward and amplification such that an ultralow-frequency zero is generated to cancel the dominant pole of LDO, while a higher frequency pole substitutes in and becomes the new dominant pole. With DPS, the loop bandwidth of the proposed LDO can be significantly extended, while a standard value and large output capacitor for transient purpose can still be used. The resultant LDO benefits from both the fast response time due to the wide loop bandwidth and the large charge reservoir from the output capacitor to achieve the significant enhancement in the dynamic performances. Implemented with a commercial 0.18-μm CMOS technology, the proposed LDO with DPS is validated to be capable of delivering 100 mA at 1.0-V output from a 1.2-V supply, with current efficiency of 99.86%. Experimental results also show that the error voltage at the output undergoing 100 mA of load transient in 10-ns edge time is about 25 mV. Line transient responses reveal that no more than 20-mV instantaneous changes at the output when the supply voltage swings between 1.2 and 1.8 V in 100 ns. The power-supply rejection ratio at 3 MHz is -47 dB.
What factors are related to recurrent preterm birth among underweight women?* (2017)

Recurrent preterm birth among underweight women was associated with younger age, short inter-pregnancy interval, and negative or no weight change between pregnancies.
Development of a renal collecting duct homing peptide using phage display (2011)

Homing peptides are useful for in vivo labeling and nonviral gene transfer to selective tissues and cell types. The aim of this project was to develop a renal collecting duct homing peptide. Using phage display, we identified a phage expressing a cyclic 7 amino acid peptide, which was internalized in a collecting duct cell line. Moreover, the phage was internalized in the collecting duct cells after i.v. injection in mice. To test if the peptide could be used for nonviral gene transfer, we synthesized the identified peptide fused to a protamine fragment. The fusion peptide was able to bind plasmid GFP cDNA and when the peptide/cDNA complex was injected i.p. in mice, GFP expression was detected in the collecting duct cells. However, GFP expression level was very low. In order to track the fate of the peptide in vivo, we synthesized a FITC labeled version of the identified peptide. Using in vivo multiphoton imaging, we found that the FITC labeled peptide was internalized in the collecting duct cells in both mice and rats. However, the peptide labeled the cells in a punctuated pattern, indicating that peptide is not able to escape the endosomes after internalization. Together, our data indicate that we have developed a peptide, which can be used to label the collecting duct cells in mice and rats; however, further development is needed in order to use the peptide as a vector for nonviral gene transfer in vivo.