gebhart/patrepeval huggingface dataset:
Structure−Activity Relationships and Effects on Neuroactive Steroid Synthesis in a Series of 2-Phenylimidazo[1,2-a]pyridineacetamide Peripheral Benzodiazepine Receptors Ligands (2004)

A series of 36 imidazopyridineacetamides (2-37) were designed and synthesized to evaluate the effects of structural changes on the amide nitrogen at both central (CBRs) and peripheral benzodiazepine receptors (PBRs). These changes include variations in the length and number of the alkyl groups as well as introduction of different aromatic, heteroaromatic, and conformationally constrained groups. The affinities of these compounds for CBRs and PBRs were determined, and the results indicate that bulkiness of the substituents, their branching, and length beyond an optimal value may cause hindrance to the ligand in its interaction with the receptor. The presence of aromatic or conformationally constrained substituents on the carboxamide nitrogen can be conducive to high affinity and selectivity. Furthermore, the ability of a subset of the most active ligands to stimulate synthesis of neuroactive steroids in plasma and brain was evaluated in vivo and in vitro. Compound 3 exhibited very marked effects on the peripheral and central synthesis of neuroactive steroids, while 36 (potent at subnanomolar level) showed a slight ability to affect neuroactive steroid content in the cerebral cortex.
Host Evasion by Emerging Paramyxoviruses: Hendra Virus and Nipah Virus V Proteins Inhibit Interferon Signaling (2004)

Interferon (IFN) can activate Signal Transducer and Activator of Transcription (STAT) proteins to establish a cellular antiviral response and inhibit virus replication. Many viruses have evolved strategies to inhibit this antiviral mechanism, but paramyxoviruses are unique in their abilities to directly target the IFN-responsive STAT proteins. Hendra virus and Nipah virus (Henipaviruses) are recently emerged paramyxoviruses that are the causative agents of fatal disease outbreaks in Australia and peninsular Malaysia. Similar to other paramyxoviruses, Henipaviruses inhibit IFN signal transduction through a virus-encoded protein called V. Recent studies have shown that Henipavirus V proteins target STAT proteins by inducing the formation of cytoplasmically localized high molecular weight STAT-containing complexes. This sequestration of STAT1 and STAT2 prevents STAT activation and blocks antiviral IFN signaling. As the V proteins are important factors for host evasion, they represent logical targets for therapeutics directed against Henipavirus epidemics.
Drug resistance of 1 175 strains of Enterobacter cloacae (2012)

Objective To explore the distribution and resistance to antimicrobial drugs of Enterobacter cloacae isolated from clinical,and provide certain evidence for the clinical use of antimicrobial drugs.Methods Sputum,blood,urine and other kinds of specimens of patients in hospital were collected.The VITEK 2 Compact system was used to identify bacteria,the VITEK 2 Compact system and KB agar diffusion method were used to do susceptibility test and analyse the distribution of pathogen and susceptibility results.Results For 1 175 strains of Enterobacter cloacae which were mainly isolated from sputum,the sputum was accounted most,which was 653 strains(55.6%),and there were 150 strains(12.8%) from urine,135 strains(11.5%) from secretion,66 strains(55.6%) from blood,etc.Those strains showed a variety of antimicrobial resistance,the ratio of antimicrobial resistance of imipenem,levofloxacin,ampicillin,and cefazolin were 2.6%,16.2%,68.8%,95.6%,respectively.Conclusion Controling the spread of resistant strains and guiding rational use of antimicrobial drugs has significant in the promptly summarized and analyzed of distribution and resistance of Enterobacter cloacae.
The utility of tablet computer technology for the on-call CT interpretation (2012)

Poster: ECR 2012 / C-0459 / The utility of tablet computer technology for the on-call CT interpretation by: M. Abu Gazala 1, R. Shreter1, R. Rozenberg1, R. Shreiber, L. Guralnik2, D. Fischer1, A. Engel1, A. Eran1; 1Haifa/IL, 2Nesher/IL
Bio-jETI: a service integration, design, and provisioning platform for orchestrated bioinformatics processes (2008)

As a service definition and provisioning platform, Bio-jETI has the potential to become a core technology in interdisciplinary service orchestration and technology transfer. Domain experts, like biologists not trained in computer science, directly define complex service orchestrations as process models and use efficient and complex bioinformatics tools in a simple and intuitive way.
New Bioactive Rosigenin Analogues and Aromatic Polyketide Metabolites from the Freshwater Aquatic Fungus Massarina tunicata (2002)

Four new rosigenin analogues (massarigenins A-D; 1-4) and two new aromatic polyketide-derived secondary metabolites (massarinins A and B; 6, 7) and have been isolated from the freshwater aquatic fungus Massarina tunicata. The structures of these compounds were determined primarily by analysis of NMR data, and that of compound 1 was verified by X-ray crystallography. The known compound 4-(2-hydroxybutynoxy)benzoic acid (11) was also obtained, and its absolute stereochemistry was assigned. Several of these metabolites showed antibiotic activity against Gram-positive bacteria.
New Structure of Dual-Layer Rewritable Phase-Change Optical Disc (2002)

In this paper, we proposed a new simple structure of dual-layer rewritable phase-change optical discs. The disc consists of only three conventional materials for rewritable disc, a phase-change layer, dielectric layers and a reflective layer. Recording, erasing and overwriting in both recording mediums of the new disc structure are demonstrated and characterized. Both recording mediums can be rewritten using the conventional recording power defined by digital versatile disc (DVD) standard.
Transport IV characterisation of MgB2conductor at a bend radius of 50mm (2014)

Performance of state of the art MgB2 multifilamentary conductor at a required bend radius is essential for many applications including but not limited to magnets and motors. The characterisation is generally done with benchmark transport Ic but further detail can be seen in IV characteristics which are undertaken in this paper. Two conductors with the same architecture but different diameters, 0.89 and 0.45 mm were measured from 32 K to 20 K in self-field in conditions of as received and deformed to a 50 mm bend diameter, corresponding to strains of 1.4 % and 0.7 % respectively. The qualifying 0.45mm conductor was further measured in background fields up to 3 T. The smaller diameter wire was found to have no signs of degradation of critical behaviour in Ic or IV characteristics
Analysis of Mitogenic Substances in Bupleurum chinense by ESR Spectroscopy. (1997)

The polyphenolic substance(s) in the hot water extract of Bupleurum chinense (PSF) showed strong mitogenic activity. In this paper, we analyzed PSF by using ESR spectroscopy, and found that i) PSF showed a strong ESR signal on g = 2.005 which was similar to the commercially available lignin; ii) Sho-saiko-to, which contains an extract of B. chinense, also showed similar signals on ESR; iii) Powdered B. chinense also showed similar signals on g = 2.005. Peroxidase activity, essential for producing polyphenolic substances, was detected in the cold water extract of B. chinense. In addition, the signal intensity of the ESR spectrum of B. chinense was increased after boiling. The data of the ESR spectra of the model reactions using lignin, arginine, proline and maltose also strongly suggested that a certain chemical modification proceeded during the hot water extraction to increase the percentage of the stable free radical. These facts strongly suggested that the mitogenic substance in B. chinense is a polyphenolic substance extracted by hot water, and the structure was modified during the extraction to increase the stable free radical components.
ChemInform Abstract: MIT CHRONOCOULOMETRISCHEN UND VOLTAMMETRISCHEN METHODEN UNTERSUCHTER MECHANISMUS DER ELEKTRODENRK. ZINK(II)‐ZINKAMALGAM IN ALKALISCHEN MEDIEN (1973)

Abstract Die Reduktion von Zn(II) und die Oxidation von Zn‐Amalgam in 0,18 bis 4,0m KOH wurden untersucht.
The Impact of Interior Cabin Noise on Passenger Acceptance (1976)

&lt;div class="htmlview paragraph"&gt;Based on flight test data gathered in general aviation aircraft, a composite motion-noise, passenger comfort model has been developed which enables the assessment of cabin interior noise impact on passenger acceptance. Relationships between special subject responses and passenger responses are given, as well as the effect of comfort on passenger acceptance. The importance of comfort and noise on the overall passenger reaction is discussed.&lt;/div&gt;
Buckling and postbuckling analysis of shells under quasi-static and dynamic loads (2001)

Thin-walled fuselage structures, partly subjected to compression and shear (torsion), are endangered by buckling. Present design procedures rest upon nonconservative conditions as to dynamic loading, e.g. landing impact, and on too conservative assumptions, if buckling due to quasi-static loading is considered. With dynamic loading like landing impact a distinction should be made between relatively short and long, quasistatic loading durations, and loadings the durations of which are in the order of the longest lateral period (lowest eigenfrequency) of the structure. A particular problem is to be expected under the later loadings where the interaction of loading dynamics with the dynamics of the buckling process may lead to substantially reduced dynamic buckling loads, as compared with the buckling loads predicted by quasi-static loading. This load reduction actually is not considered in the design process. In order to overcome that problem, a fast and reliable simulation procedure has to be developed. With buckling due to quasi-static loading, experiments have shown that the potential exists for further weight savings with stiffened composite structures by allowing postbuckling of the skin to occur during operation. Proper design enables the structures to act far within the postbuckling regime without any damage. This demand requires the development of an appropriate fast and reliable simulation procedure.
A 0.5-to-2.5GHz supply-regulated PLL with noise sensitivity of &#x2212;28dB (2008)

A supply-regulated phase-locked loop (PLL) employs a split-tuned architecture to decouple the tradeoff between supply-noise rejection performance and power consumption. The prototype PLL, incorporating a novel regulator, is fabricated in a 0.18 mum digital CMOS process and operates from 0.5 to 2.5 GHz. At 1.5 GHz, the proposed PLL achieves a worst-case noise sensitivity of -28 dB (0.5 rad/V), an improvement of 20 dB over conventional solutions, while consuming 2.2 mA from a 1.8 V supply.
Catalytic Cracking of Biodiesel Waste Using Metal Supported SBA-15 Mesoporous Catalysts (2019)

Palladium (Pd) and aluminium (Al) supported on SBA-15 were prepared as catalysts for cracking biodiesel waste from biodiesel production. Mesoporous silica SBA-15 was first synthesized by a hydrothermal method and then loaded with Al or Pd particles were loaded using postsynthesis or aqueous wet impregnation methods, respectively. The physical properties of the catalysts were characterized by X-ray diffraction (XRD), nitrogen (N2) adsorption, scanning electron microscopy (SEM), and transmission electron microscopy (TEM) analyses. The catalytic cracking performance of biodiesel waste was evaluated at reaction temperatures above 400 °C under a N2 atmosphere in a batch reactor for 40 min in comparison with that for pure glycerol, where the conversion of biodiesel waste reached 86.8% with 10 wt% Pd-SBA-15 at 650 °C. The product types depended on whether the starting material was pure glycerol or biodiesel waste. The main gaseous products were carbon monoxide as synthesis gas, carbon dioxide, and 1,3-butadiene. Additionally, 2-cyclopenten-1-one and 2-propen-1-ol were major products in the liquid fraction, which can be used in pharmaceuticals and as a flame retardant, respectively.
Physical learning beyond the quasistatic limit (2022)

Physical networks, such as biological neural networks, can learn desired functions without a central processor, using local learning rules in space and time to learn in a fully distributed manner. Learning approaches such as equilibrium propagation, directed aging, and coupled learning similarly exploit local rules to accomplish learning in physical networks such as mechanical, flow, or electrical networks. In contrast to certain natural neural networks, however, such approaches have so far been restricted to the quasistatic limit, where they learn on timescales slow compared to their physical relaxation. This quasistatic constraint slows down learning, limiting the use of these methods as machine learning algorithms, and potentially restricting physical networks that could be used as learning platforms. Here we explore learning in an electrical resistor network that implements coupled learning, both in the laboratory and on the computer, at rates that range from slow to far above the quasistatic limit. We find that up to a critical threshold in the ratio of the learning rate to the physical rate of relaxation, learning speeds up without much change of behavior or error. Beyond the critical threshold, the error exhibits oscillatory dynamics but the networks still learn successfully.
Design of continuous-time sigma-delta modulators with arbitrary feedback waveform (2003)

This paper considers the discretization of continuous-time sigma-delta modulators without any constraint on the shape or duration of the feedback signal. A motivation for taking the shape of the feedback signal into account is the system-level compensation of nonidealities encountered in a practical design. Two different discretization approaches based on state-variables and the modified z transform are presented. Explicit formulas for an exact mapping between continuous-time and discrete-time modulators are derived. Subsequently, design of multistage continuous-time modulators using arbitrary feedback waveforms is discussed.
Drug Abuse Prevalence and Risk Factors in Students of Shaheed Sadoughi University of Medical Sciences, Yazd (2010)

Introduction: Addiction and drug abuse in one of the most important health, social and political problems in the world, especially in developing countries. Nowadays this problem has higher prevalence in young people, and so students of the universities are at risk. The aim of this study was to identify drug abuse prevalence and risk factors in students of Shaheed Sadoughi Medical University, Iran, Yazd Methods: This was a descriptive cross sectional study and 534 students were selected through random sampling from different medical sciences colleges. The data was collected by self-designed questionnaire and interview, and then analyzed using SPSS software and chi-square test. Results: Data showed the prevalence of drug abuse in students to be 21.5%, frequency of drug abuse was as follows: Hookah 15.9%, cigarette 24.13%, opium 2.8%. The major risk factors were amusement 47.4% and unemployment 42.98%. It was higher in single males who lived in university dormitories. Conclusion: According to the study results, it is recommended that families and university managers facilitate student's entertainment, marriage and occupation. The high prevalence of smoking hookah which is usually accompanied by use of other drugs should be considered in educational programs.
ICAM-1–activated Src and eNOS signaling increase endothelial cell surface PECAM-1 adhesivity and neutrophil transmigration (2012)

Polymorphonuclear neutrophil (PMN) extravasation requires selectin-mediated tethering, intercellular adhesion molecule-1 (ICAM-1)-dependent firm adhesion, and platelet/endothelial cell adhesion molecule 1 (PECAM-1)-mediated transendothelial migration. An important unanswered question is whether ICAM-1-activated signaling contributes to PMN transmigration mediated by PECAM-1. We tested this concept and the roles of endothelial nitric oxide synthase (eNOS) and Src activated by PMN ligation of ICAM-1 in mediating PECAM-1-dependent PMN transmigration. We observed that lung PMN infiltration in vivo induced in carrageenan-injected WT mice was significantly reduced in ICAM-1(-/-) and eNOS(-/-) mice. Crosslinking WT mouse ICAM-1 expressed in human endothelial cells (ECs), but not the phospho-defective Tyr(518)Phe ICAM-1 mutant, induced SHP-2-dependent Src Tyr530 dephosphorylation that resulted in Src activation. ICAM-1 activation also stimulated phosphorylation of Akt (p-Ser473) and eNOS (p-Ser1177), thereby increasing NO production. PMN migration across EC monolayers was abolished in cells expressing the Tyr(518)Phe ICAM-1 mutant or by pretreatment with either the Src inhibitor PP2 or eNOS inhibitor L-NAME. Importantly, phospho-ICAM-1 induction of Src signaling induced PECAM-1 Tyr686 phosphorylation and increased EC surface anti-PECAM-1 mAb-binding activity. These results collectively show that ICAM-1-activated Src and eNOS signaling sequentially induce PECAM-1-mediated PMN transendothelial migration. Both Src and eNOS inhibition may be important therapeutic targets to prevent or limit vascular inflammation.
Re-Analysis of Deep Excavation Collapse Using a Generalized Effective Stress Soil Model (2010)

This paper re-analyzes the well-documented failure of a 30m deep braced excavation in underconsolidated marine clay using an advanced effective stress soil model (MIT-E3). The collapse of the Nicoll Highway during construction of cut-and cover tunnels for the new Circle Line in Singapore has been extensively investigated and documented. All prior analyses of the collapse have relied on simplified soil models with undrained strength parameters based on empirical correlations and piezocone penetration data. The current analysis use results from high quality consolidation and undrained triaxial shear tests that were only available after completion of the public inquiry. The current analyses achieve very reasonable estimates of measured wall deflections and strut loads using model parameters derived directly from the laboratory tests. The analyses confirm prior interpretations of the failure mechanism but provide a more rational basis for the modeling of soil-structure interaction.
The quantum dot spectrometer (1997)

We propose a novel photodetector capable of multi-spectral channel operation. The device makes use of the ability of a quantum dot plane to capture an optical spectrum, and of a resonant-tunneling structure to perform spectrally sensitive read-out. We present a design made out in the InAs–GaAs–AlxGa1−xAs system. We also present realistic simulations of the optical channel capabilities, as well as a discussion of the possible problems of the device.
Supplementary Table from Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer (2023)

Supplementary Table from Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer
Preparation of N-(2-naphthyl)-2-amino acids and esters of high enantiomeric purity (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation of N-(2-naphthyl)-2-amino acids and esters of high enantiomeric purityWilliam H. Pirkle and Thomas C. PochapskyCite this: J. Org. Chem. 1986, 51, 1, 102–105Publication Date (Print):January 1, 1986Publication History Published online1 May 2002Published inissue 1 January 1986https://pubs.acs.org/doi/10.1021/jo00351a024https://doi.org/10.1021/jo00351a024research-articleACS PublicationsRequest reuse permissionsArticle Views484Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
LDPC code optimization with joint source-channel decoding of quantized Gauss-Markov signals (2014)

This paper proposes an extrinsic information transfer (EXIT)-chart based optimization technique of LDPC codes for the transmission of quantized Gauss-Markov (GM) source samples over additive white Gaussian (AWGN) noise channels. A joint source and channel (JSC) decoding technique of the proposed code is also devised. In the proposed scheme, no interleaving is performed between the source and the JSC encoder so that the decoder can well exploit the relatively low entropy of the source with memory compared to memory-less sources. At the transmitter, the quantized samples are converted to bit sequences with an injective mapping and the bit sequences are encoded using a systematic binary LDPC code. The proposed JSC decoder is a concatenation of a multi-state BCJR Markov decoder and a sum-product (SP) LDPC decoder. Decoding thresholds of the optimized codes at certain code rates are investigated for both uniform and Lloyd-Max quantizations in different numbers of bits. The decoding thresholds are close to the Gaussian code book Shannon limits for code rate R <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">c</sub> ≤ 0.5, although the gap to the Shannon limit notably increases at the higher rates. Finally, the simulation results confirm the significant improvement of coding gain on the bit error rate (BER) performances of the optimized LDPC codes with both the quantization schemes.
Selective attraction of eosinophils and synergism between eosinophil chemotactic factor of anaphylaxis (ECF-A) and a fragment cleaved from the fifth component of complement (C5a). (1973)

ECF-A and C5a were chemotactic both for eosinophils and neutrophils. However, when eosinophils comprised approximately 10 per cent or more of a mixed leucocyte population, they were preferentially attracted by both of these agents. Marked synergism was observed between ECF-A and C5a in their ability to attract eosinophil leucocytes.
Peports of 1994 TAPPI Papermakers Conference (1994)

[in Japanese]
Association between Body Mass Index and Serum Dehydroepiandrosterone Sulfate Level in 8-Year-Old Girls (2018)

BMI SDS was associated with DHEAS level, which was associated with BA/CA. Childhood obesity may influence the development of adrenarche, which may contribute to advanced skeletal maturation.