gebhart/patrepeval huggingface dataset:
Performance of dairy cows under grazing alfalfa: nutritional management for the winter season. (2014)

The intensive of milk yield systems, the high cost of the crop yield, saddled the economic sustainability of dairy activity. The quantities and percentages of concentrated ingredients, it's high to meet desired yield level. Thus, the alfalfa by high nutritional value allows the used as a substitute for part of the concentrated feed, with a reduction in the cost of milk yield and maintain the quality of the diet. In this way, the objective of this study was to evaluate the performance of 36 cows Holstein X Jersey crossbreed, average lactation stage, with the partial replacement of silage corn for alfalfa pasture. In a randomized block design, in 90 days of experimental time, composed of four treatments: control; one; two; and four hours of daily grazing in alfalfa. The grazing management was rotated, and the amount of alfalfa corresponding to 3.0; 5.0 and 7.0 kg of dry matter (kg of DM.animal-1.day-1), for 1, 2 and 4 hours of grazing, respectively. The parameters evaluated were: milk yield, live body weight, dry matter intake, milk quality, animal behavior and economic viability. The average milk yield did not differ between treatments (P>0.05), whose averages were 29.17; 28.60; 27.87 and 28.34 liters.animal-1.day-1 in the control group, 1, 2 and 4 hours of grazing, respectively. It were not reported significant differences (P>0.05), for animal behavior and milk quality, with the exception of treatment of control group, who presented level of N-ureic in milk above the treatmento 1, 2 and 4 hours (P<0.05) and 19 mg/dL, the treatments 2 and 4 hours showed about 0.76% and 4.42% more profitable when compared to the control group. The partial replacement of silage corn for alfalfa grazing not limited the productive animals performance and proved to be economically advantageous in relation to confinement.
Analyse de l'instabilité de cavitation dans un inducteur par modélisation de l'écoulement instationnaire en grille d'aubes (2001)

Click to increase image sizeClick to decrease image sizeAn analysis of cavitation instabilities in rocket-engines inducers is developed by the LEGI in collaboration with the CNES and Snecma-Moteurs DMF. It is based on the modelling of the unsteady cavitating flow in a 2D blade cascade. Computations taking into account the complete coupling between the different blade-to-blade channels are carried out. They lead, according to the operation point, either to a stable and symmetrical behaviour of the cavitation on the different blades, or to a non-symmetrical and unsteady behaviour, showing in the different channels different structures of cavitation, whose distribution is in rotation with respect to the rotor. In these last cases, a super-synchronous instability, which agrees with experimental observations in this type of machine, is obtained in the stator frame.
Measurement ofπ0photoproduction on the proton at MAMI C (2015)

Differential cross sections for the $\ensuremath{\gamma}p\ensuremath{\rightarrow}{\ensuremath{\pi}}^{0}p$ reaction have been measured with the A2 tagged-photon facilities at the Mainz Microtron, MAMI C, up to the center-of-mass energy $W=1.9\phantom{\rule{4.pt}{0ex}}\mathrm{GeV}$. The new results, obtained with a fine energy and angular binning, increase the existing quantity of ${\ensuremath{\pi}}^{0}$ photoproduction data by $\ensuremath{\sim}47%$. Owing to the unprecedented statistical accuracy and the full angular coverage, the results are sensitive to high partial-wave amplitudes. This is demonstrated by the decomposition of the differential cross sections in terms of Legendre polynomials and by further comparison to model predictions. A new solution of the SAID partial-wave analysis obtained after adding the new data into the fit is presented.
Zirconimphosphit‐(3,3′5,5′‐tetramethylbiphenyl)diphosphonat: ein mikroporöses anorganisch‐organisches Polymer mit Sälen‐Schichtstruktur (1993)

Einheitlich große Poren hat die Titelverbindung (Strukturmodell rechts), in der α‐Zirconiumphosphatschichten durch senkrecht dazu orientierte Biphenyleinheiten verbunden werden. So bildet sich ein Polymer, das von Interesse für formselektive Katalysen und als Molekularsieb ist und dessen Architektur an die von griechischen Tempeln erinnert. magnified image
Social coordination in animal vocal interactions: is there any evidence of turn taking? The example of the European starling (2015)

National audience
Figure S4 from Surfactant Expression Defines an Inflamed Subtype of Lung Adenocarcinoma Brain Metastases that Correlates with Prolonged Survival (2023)

&lt;p&gt;Boxplots comparing the infiltration of TIL subsets for preoperative treatments (chemotherapy or other systemic therapy) as well as for the comparison of synchronous vs. metachronous brain metastases.&lt;/p&gt;
Pre-pro-B Cell Growth-Stimulating Factor (PPBSF) Upregulates IL-7R α Chain Expression and Enables pro-B Cells to Respond to Monomeric IL-7 (2002)

Although pro-B cells are well represented in IL-7 knockout (KO) mice, they express abnormally low concentrations of the interleukin-7 receptor alpha-chain (IL-7Ralpha) and do not generate pre-B cells. Here, we demonstrate that pro-B cells from IL-7 KO mice can be induced to generate pre-B cells and immature B cells by exposure to recombinant IL-7 (rIL-7) in vivo but not in vitro. Experiments in recombinant activation gene-1 (RAG-1) KO mice indicate that the in vitro unresponsiveness of IL-7(-/-) pro-B cells to rIL-7 is unrelated to the absence of a functional pre-B cell receptor (pre-BCR). Rather, it appears to be due to the suboptimal expression of the IL-7Ralpha chain. Thus, IL-7(-/-) pro-B cells readily respond to rIL-7 in vitro if IL-7Ralpha chain expression is first upregulated by exposure to IL-7 in vivo or to IL-7(+/+) bone marrow (BM) stromal cells or conditioned medium (CM) therefrom in vitro. Similar results were obtained when pro-B cells from IL-7 KO mice were cultured on IL-7(-/-) BM stromal cells in the presence of rIL-7. This suggested that the recently described pre-pro-B cell growth-stimulating factor (PPBSF), a self-assembling hybrid cytokine comprising IL-7 and the stromal cell-derived hepatocyte growth factor beta-chain (HGFbeta), is required to stimulate pro-B cells from IL-7 KO mice. This inference was verified by demonstrating that purified PPBSF upregulates IL-7Ralpha chain expression on IL-7(-/-) pro-B cells in vitro and enables them to respond to rIL-7 in a stepwise manner. We, therefore, postulate that PPBSF is the operative form of IL-7 that normally induces IL-7Ralpha(lo) pre-pro-B cells to proliferate and differentiate into IL-7Ralpha(hi) pro-B cells, which then proliferate and differentiate into pre-B cells on stimulation with monomeric IL-7.
ChemInform Abstract: [16.16.16](1,3,5)Cyclophanetetracosayne (C60H6): A Precursor to C60 Fullerene. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Insect Cell Culture Engineering: An Overview (2020)

The culturing conditions for insect and mammalian cells are similar. Most of the culture techniques have evolved through the modification of mammalian cell culture procedures. Cell damage due to excessive mechanical agitation may be associated with bubble entrainment in the fluid due to vortexing or cavitation. Due in part to the addition of fetal bovine or calf serum, typical insect cell culture media, such as Grace’s, tend to be quite complex. The insect cell/baculovirus expression system has its limitations. The expression of a foreign gene comes at the end of the infection cycle, at a time when the host cell is in the process of degradation. Mammalian cell suspension culture has been limited, to some extent, by relatively low cell densities and product concentrations. The capsule membrane selectively allows small molecules such as nutrients and oxygen to freely diffuse through, but prevents the passage of large molecules and cells.
Intelligent Link Adaptation in 802.11 Vehicular Networks: Challenges and Solutions (2019)

By providing effective wireless vehicle-to-everything (V2X) communication, it is expected that the Internet of Vehicles will be provisioned, whereby various automotive service requirements could be satisfied (enhanced road safety, improved transportation efficiency, etc.). Despite the successful standardization of 802.11-based communication protocols in vehicular networks (e.g., 802.11p, 802.11af), there remains an essential issue, which is to adjust the transmission rate and mode to match the highly dynamic channel conditions in vehicular scenarios. In this article, we first investigate the requirements for intelligent link adaptation (LA) in 802.11 V2X, and then present a data-driven learning-based LA architecture that fits the road channel characteristics while capturing the quick variance due to the high mobility of vehicular networks. We also propose a reference model to show how the data-driven model can efficiently catch the channel variance and improve the “drive-thru Internet” throughput. Finally, we discuss the opportunities and challenges, which should provide significant reference for the development and standardization of the intelligent LA solution in 802.11 V2X networks.
Search in Random Media with Lévy Flights (2013)

We review some of our work regarding search which has been motivated by a variety of applications in engineering and technology, including traffic routing and security in communication networks, explosive mine detection and removal, tactical operations as well as emergency management. We develop the basic mathematical model representing N searchers that proceed independently, and which can be affected by destruction or loss, and time-outs. An approach based on Laplace transform is then developed for the case where the success of the search requires that k out of the N searchers be successful, and we estimate the amount of energy expended and the number of searchers that are required to conduct a successful search in time B, provided B is large. Finally, we present an iterative numerical solution approach that allows us to analyse the search time and the energy needed to find an object when the search space is non-homogeneous.
Caspase-3 Is Required for DNA Fragmentation and Morphological Changes Associated with Apoptosis (1998)

Interleukin 1beta-converting enzyme-like proteases (caspases) are crucial components of cell death pathways. Among the caspases identified, caspase-3 stands out because it is commonly activated by numerous death signals and cleaves a variety of important cellular proteins. Studies in caspase-3 knock-out mice have shown that this protease is essential for brain development. To investigate the requirement for caspase-3 in apoptosis, we took advantage of the MCF-7 breast carcinoma cell line, which we show here has lost caspase-3 owing to a 47-base pair deletion within exon 3 of the CASP-3 gene. This deletion results in the skipping of exon 3 during pre-mRNA splicing, thereby abrogating translation of the CASP-3 mRNA. Although MCF-7 cells were still sensitive to tumor necrosis factor (TNF)- or staurosporine-induced apoptosis, no DNA fragmentation was observed. In addition, MCF-7 cells undergoing cell death did not display some of the distinct morphological features typical of apoptotic cells such as shrinkage and blebbing. Introduction of the CASP-3 gene into MCF-7 cells resulted in DNA fragmentation and cellular blebbing following TNF treatment. These results indicate that although caspase-3 is not essential for TNF- or staurosporine-induced apoptosis, it is required for DNA fragmentation and some of the typical morphological changes of cells undergoing apoptosis.
Electrochemical Corrosion Study of Metallic Materials in Phosphoric Acid as Bipolar Plates for HT-PEFCs (2014)

This work investigates various commercially available austenitic stainless steels and Ni-based alloys as possible metallic bipolar plates for high-temperature polymer electrolyte fuel cells (HT-PEFCs). The dynamic formation and depletion of passivation layers that depends strongly on applied potential was analyzed in 85 wt% phosphoric acid at RT and 130°C by means of cyclic voltammetry and steady-state polarization. All materials showed a beneficial passivation in the potential window 0.3–1.2 V, which is mainly based on a stable inner Cr2O3 layer, and a reduction of the passive layers at cathodic polarization. Alloy 2.4869 (Cronix 80) with 80 wt% Ni and 20 wt% Cr reveals the lowest corrosion rates of 16.1 μA cm−2 at 130°C in the passive region at 0.6 V and a free corrosion potential Ecor of 235 mV. The improvement of passivity was achieved by the dominant superficial Ni3(PO4)2 layer. Alloying additions Mo and Ti revealed a characteristic increase of passive current densities due to instability of these passivation components at 130°C. Passivation based on Fe oxides and phosphates in stainless steels shows to be beneficial at RT, but less efficient at 130°C.
A soft robot structure with limbless resonant, stick and slip locomotion (2019)

Abstract We present a smart robot structure that exploits anisotropic friction to achieve stick-slip locomotion. The robot is made out of three components: a plastic beam, a planar dielectric elastomer actuator and four bristle pads with asymmetric rigid metallic bristles. We show that when the robot is electronically activated at increasing frequency, its structure exploits the resonance condition to reach the maximum locomotion speed. The fundamental frequency of the structure is estimated both analytically and numerically, allowing the range of frequencies in which the top locomotion speed was observed during the experiments to be identified. The locomotion speed of the robot as a function of the actuation frequency is estimated with a frequency response analysis performed on a discretised model of the structure, revealing good agreement with the experimental evidence.
The BI-RADS 5th edition density scale and breast cancer risk: a case-control study (2016)

Poster: ECR 2016 / C-2316 / The BI-RADS 5th edition density scale and breast cancer risk: a case-control study by: M. Abdolell 1, K. Tsuruda1, C. B. Lightfoot1, P. Brown1, S. A. Raza2, G. Schaller1, J. Caines1, J. I. Payne1, S. Iles1; 1Halifax, NS/CA, 2Sydney, NS/CA
The need for a multi-level drug targeting strategy to curb the COVID-19 pandemic (2021)

Thousands of drugs, nutraceuticals and their combinations can be used to select candidate therapeutics for targeting SARS-CoV-2 and its symptoms in order to curb COVID-19. A comprehensive, multi-level strategy against COVID-19 should include drug targeting of biomolecules and biochemical pathways involved in the prevention and proliferation of the infection, and the fatal or serious symptoms following infection. Several drugs are routinely used in the treatment of different categories of seriously ill COVID-19 patients including tocilizumab, remdesivir and dexamethasone. The current risk/benefit assessment supports the emergency testing and approval of more drugs. The process for new drug selection could be based on the identification of one drug for one target, or of a multi-potent drug for many targets and drug combinations for one or more targets, that can cause a substantial reduction in the high mortality rate of COVID-19. Several drugs have been identified that can fit this potential role by targeting different stages of COVID-19 including baricitinib, molnupiravir and PF-07321332/ritonavir and also the combination of deferiprone with N-acetylcysteine for inhibiting the vicious circle of oxidative stress toxicity and endothelial cell damage. Most of these drugs are expected to be effective against all the SARS-CoV-2 variants including Omicron (B.1.1.529) and also the associated COVID-19 complications.
Novel Treatment of Meningitis Caused by Multidrug-Resistant Mycobacterium tuberculosis with Intrathecal Levofloxacin and Amikacin: Case Report (2001)

We report the case of a 25-year-old HIV-negative man with disseminated multidrug-resistant tuberculosis (MDRTB), who-on a retreatment regimen-experienced total resolution of TB miliary disease, but progressive TB meningitis. Therefore, intrathecal treatment with amikacin and levofloxacin was instituted, with successful clinical and microbiological results.
Liver-Kidney Transplantation to Cure Atypical Hemolytic Uremic Syndrome (2008)

Atypical hemolytic uremic syndrome is often associated with mutations in genes encoding complement regulatory proteins and secondary disorders of complement regulation. Progression to kidney failure and recurrence with graft loss after kidney transplantation are frequent. The most common mutation is in the gene encoding complement factor H. Combined liver-kidney transplantation may correct this complement abnormality and prevent recurrence when the defect involves genes encoding circulating proteins that are synthesized in the liver, such as factor H or I. Good outcomes have been reported when surgery is associated with intensified plasma therapy. A consensus conference to establish treatment guidelines for atypical hemolytic uremic syndrome was held in Bergamo in December 2007. The recommendations in this article are the result of combined clinical experience, shared research expertise, and a review of the literature and registry information. This statement defines groups in which isolated kidney transplantation is extremely unlikely to be successful and a combined liver-kidney transplant is recommended and also defines those for whom kidney transplant remains a viable option. Although combined liver-kidney or isolated liver transplantation is the preferred therapeutic option in many cases, the gravity of risk associated with the procedure has not been eliminated completely, and assessment of risk and benefit requires careful and individual attention.
Virtual-SRE For Monitoring Large Scale Time-series Data (2021)

Monitoring online time-series data and providing real-time alerts are crucial for a variety of industry applications. But doing it at a large scale is a challenging task. In this paper, we introduce Virtual-SRE, an anomaly detection framework which utilizes human knowledge and is suitable for large-scale applications. The proposed approach starts without any human labeling. Instead, human knowledge is obtained through feedbacks. A joint data and model optimization process is proposed to ensure that accurate models can be built. This makes it easily applicable to large-scale and heterogeneous tasks while enjoying the benefits of supervised learning. The proposed framework has been deployed to monitor thousands of time-series data streams and obtained favorable results.
Trans-rectal ultrasound-coupled spectral optical tomography at 785nm and 830nm detects elevation of total hemoglobin concentration in canine prostate associated with the development of transmissible venereal tumors (2010)

Spectral trans-rectal ultrasound-coupled optical tomography at 785nm and 830nm has revealed non-invasively longitudinal elevation of total hemoglobin concentration associated with development of transmissible venereal tumors in canine prostate over a 6-week time-course.
Mitochondrial ROS is involved in downregulation of hERG by hypoxia (2008)

We previously reported that hypoxia attenuated hERG current density and protein expression in HEK cells stably expressing hERG protein. In the present study, we examined the role of reactive oxygen species (ROS) in hypoxia‐induced downregulation of hERG. Hypoxia elevated ROS levels and the time course of the response correlated with hERG downregulation. ROS scavengers restored hERG expression in hypoxia exposed cells. Treatment of cells with X/XO (500μm/5milliunits/ml) under normoxic conditions mimicked the effect of hypoxia. Cellular sources of ROS include inhibition of the electron transport chain (ETC) of the mitochondria as well as NADPH oxidases. Apocyanin (1mM) and DPI (10μM), NADPH oxidase inhibitors, were ineffective in preventing hypoxia induced down‐regulation of hERG protein. In contrast, stigmatellin (1μm) and myxthiazole (1μM), mitochondrial complex III inhibitors prevented hypoxia‐induced downregulation of hERG. More importantly, effects of hypoxia on hERG protein were markedly attenuated or abolished in ρ0 cells deficient in mitochondrial DNA. Moreover, hypoxia did not increase ROS levels in ρ0 cells. These results suggest that ROS generated by mitochondrial ETC are involved in hypoxia‐evoked downregulation of hERG protein. (Supported by NIH‐HL‐25830).
Novel method for depth-resolved brain functional imaging by time-domain NIRS (2007)

A novel approach to improve depth selectivity based on time-domain contrast functions is presented. The method was tested with Monte Carlo simulations showing sensitivity to absorption changes of deep inclusions and improved rejection of superficial effects. Preliminary in-vivo measurements were performed on healthy volunteer during a Valsalva maneuver and during finger tapping discriminating brain cortex activation from hemodynamic changes associated to systemic effects in the scalp.
Generation of high-energy localized vibrational modes in nonlinear Klein-Gordon lattices (1996)

We study numerically the exchange of energy and momentum between colliding breathers in nonlinear Klein-Gordon lattices as a means of obtaining localization of energy. Statistical calculations show a clear preference of the larger breather to take energy from the smaller one in the whole energy range of interest. Thus it represents an effective mechanism for energy localization in nonlinear Klein-Gordon lattices, originating from the discreteness and nonintegrability of the system. To get initial conditions for our simulations we numerically calculate exact single-frequency static breather solutions using a technique recently discovered by Flach [Phys. Rev. E 51, 3579 (1995)].