gebhart/patrepeval huggingface dataset:
Induction of Apoptosis by Antisense CK2 in Human Prostate Cancer Xenograft Model (2004)

Protein serine/threonine kinase CK2 (formerly casein kinase 2) is a ubiquitous protein kinase that plays key roles in cell growth, proliferation, and survival. We have shown previously that its molecular down-regulation induces apoptosis in cancer cells in culture. Here, we have employed a xenograft model of prostate cancer to extend these studies to determine whether antisense CK2alpha evokes a similar response in vivo. A single dose of antisense CK2alpha oligodeoxynucleotide given directly into the PC3-LN4 xenograft tumor in nude mouse induced a dose- and time-dependent tumor cell death in vivo. The tumor was completely resolved at the higher tested dose of the antisense. Cell death was due to apoptosis and correlated with a potent down-regulation of the CK2alpha message and loss of CK2 from the nuclear matrix in the xenograft tissue as well as in cancer cells in culture. These observations accorded with several of the earlier studies indicating that loss of CK2 from the nuclear matrix is associated with induction of apoptosis. Comparison of the effects of antisense CK2alpha oligodeoxynucleotide on cancer versus normal or noncancer cells showed that the concentration of antisense CK2alpha that elicited extensive apoptosis in tumor cells in culture or xenograft tumors in vivo had a relatively small or minimal effect on noncancer cells in culture or on normal prostate gland subjected to orthotopic injection of antisense oligodeoxynucleotide in vivo. The basis for the difference in sensitivity of cancer versus noncancer cells to antisense CK2alpha is unknown at this time; however, this differential response under similar conditions of treatment may be significant in considering the potential feasibility of targeting the CK2 signal for induction of apoptosis in cancer cells in vivo. Although much further work will be needed to establish the feasibility of targeting CK2 for cancer therapy, to our knowledge, this is the first report to provide important new evidence as an initial "proof of principle" for the potential application of antisense CK2alpha in cancer therapy, paving the way for future detailed studies of approaches to targeting CK2 in vivo to induce cancer cell death.
Suzuki–Miyaura coupling of quinazolines containing an unprotected NH2 group: Synthesis and biological testing of quinazoline derivatives (2017)

A robust approach to 4-amino quinazoline bi-aryl compounds was developed through Suzuki–Miyaura coupling reaction of quinazoline containing an unprotected NH2 group and arylboronic acids. Pd(dcpf)Cl2 was found to be an efficient catalyst for the reaction. All the compounds were evaluated for antimicrobial activity against gram-positive and gram-negative bacteria and fungi. One of the compounds, 3l, found to be more active against Candida albicans than the standard Miconazole.
Epitaxial growth and electronic structure of LaTiOx films (2002)

LaTiO x films have been grown on (001) perovskite oxide substrates by pulsed-laser deposition. Both single-phase perovskite LaTiO3 and layered La2Ti2O7 films could be stabilized by varying the oxygen partial pressure and substrate temperature during growth. We have obtained a crystallographic and electronic phase diagram for LaTiOx films, demonstrating the ability to vary the titanium valence from 3+ to 4+ in thermodynamically unfavorable growth conditions by utilizing interface energies.
Optimum Transverse Span Loading for Subsonic Transport Category Aircraft (2012)

This study considers the overall system impact of the design transverse aerodynamic load distribution on future subsonic, transport category aircraft. The fundamental question revisited here concerns wing design ground rules. Should the wing be designed to favor an aerodynamically optimal, “elliptical” transverse span load that minimizes induced drag? Or, should the wing be tailored to have a reduced root bending moment in order to save structural weight at some expense of increased drag? The problem is examined at three levels of technical scrutiny: from a qualitative, rational basis perspective; from a quantitative, intermediate-fidelity parametric performance perspective; and from the results of a quantitative, coupled multidisciplinary optimization trade. The quantitative tradesindicatethattailoringofthedesigntransverseloaddistributiontofavorareducedwingrootbendingmoment resultsinsomestructuralweightsavings,butattheexpenseofhigherdrag,increasedfuelconsumption,andreduced mission performance. These trades substantiate a different rational basis argument: a balancing test that will typically recommend the aerodynamically optimal design for all but the shortest-range aircraft.
Two-dimensional electron gases in quantum well and superlattices of Ga0.25In0.75As0.50P0.50/InP heterostructures grown by low pressure metalorganic chemical vapor deposition (1985)

We report the first observation of a two-dimensional electron gas from Shubnikov–de Haas experiments, in a Ga0.25In0.75As0.50P0.50-InP heterojunction, multi-quantum well, and superlattices grown by metalorganic chemical vapor deposition at reduced pressure.
Localization Properties Of An Eeg Sensor System: Lower Bounds And Optimality (2004)

Publication in the conference proceedings of EUSIPCO, Viena, Austria, 2004
Current European concepts in the management of Helicobacter pylori infection - the Maastricht Consensus Report (1997)

Malfertheiner, P.; Mégraud, F.; O'Morain, C.; Bell, D.; Porro, Bianchi G.; Deltenre, M.; Forman, D.; Gasbarrini, G.; Jaup, B.; Misiewicz, J. J.; Pajares, J.; Quina, M.; Rauws, E. for the European Helicobacter Pylori Study Group (EHPSG)
Mechanics of Wound Closure: Emerging Tape-Based Wound Closure Technology vs. Traditional Methods (2016)

To date, there is still a lack of understanding of how wound closure methods perform comparatively under daily bodily movement during the course of healing and how they affect the mechanics of healing. The present study is a first step in understanding and objectively quantifying the gap. The study provides both a new method of metrology for noninvasive evaluation of skin mechanics at the onset of wound healing and an emerging tape-based wound closure technology. The latter shows better performance with respect to commonly used staples and sutures, holding the wound intact and providing uniform mechanical support across the incision.
Noninvasive Measures of Liver Fibrosis (2006)

As novel therapies for liver fibrosis evolve, non-invasive measurement of liver fibrosis will be required to help manage patients with chronic liver disease. Although liver biopsy is the current and time-honored gold standard for measurement of liver fibrosis, it is poorly suited to frequent monitoring because of its expense and morbidity, and its accuracy suffers from sampling variation. At the current writing, serum markers and imaging methods are available and increasingly in use as alternatives to biopsy. However, many questions remain about their indications, accuracy, and cost-effectiveness, and more investigation is required before they are put into widespread use. The development of safe, inexpensive, and reliable noninvasive fibrosis measurement tools remains a research priority in clinical hepatology.
Analysis and Experimental Verification of Diameter Attacks in Long Term Evolution Networks (2016)

In cellular networks, the roaming interconnection was designed when there were only a few trusted parties and security was not a major concern or design criteria. Most of the roaming interconnections today are still based on the decades-old SS7 and the lack of security is being blamed for several vulnerabilities. Recent research indicates that the roaming interconnection has been widely misused for gaining access to the core network. Several attacks have been demonstrated by malicious attackers and other unauthorized entities such as intelligence agencies by exploiting the SS7 signaling protocol. Some operators moved to the more modern LTE (Long Term Evolution) and Diameter Signaling for high-speed data roaming and enhanced security. While LTE offers very high quality and resilience over the air security, it still requires special security capabilities and features to secure the core network against attacks targeting the roaming interconnection. This thesis analyses and identifies attacks that exploit the roaming interconnection and Diameter signaling used in LTE networks. The attacks are analyzed in accordance with the mobile network protocol standards and signaling scenarios. The attacks are also implemented in a test LTE network of a global operator. This thesis also focuses on potential countermeasures to mitigate the identified attacks.
Mathematical Modeling of Thermohydrodynamic Processes in a Formation with Hydraulic Fracturing in a Fluid Injection Mode (2020)

Summary The present work is devoted to the study of thermohydrodynamic processes in a well and formation to study the possibility of determination of operating intervals by temperature measurements in injection wells with hydraulic fractures in quasi-stationary injection mode.
Critical Reroute: A Practical Approach to Network Flow Prioritization using Segment Routing (2019)

It is widely recognized that reliable communications are a key element of a successful response to a disaster situation. To address this need, local and regional governments in all parts of the world have deployed dedicated communications networks for first responders. These systems are often prohibitively expensive, voice-only, and are needed only on rare occasions. It would be more cost-effective to use already-existing networks or to deploy networks for shared use. However, due to the sudden increase in demand or physical failure caused by the disaster, shared networks may become overloaded. In such situations, it would be desirable to prioritize traffic flows belonging to public safety applications over others. Solutions such as priority queuing and differentiated services provide partial answers to that goal but leave other problems unsolved. This work presents a novel solution using Segment Routing and a Genetic Algorithm optimizer to minimize the impact of network overload on critical traffic flows. The results show that these methods can reroute flows using a single midpoint such that the total network overload is reduced compared to traditional shortest-path routing while avoiding unnecessarily long paths and taking priority of flows into account.
A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells (2019)

Summary Ovarian cancer is typified by the development of chemotherapy resistance. Chemotherapy resistance is associated with high aldehyde dehydrogenase (ALDH) enzymatic activity, increased cancer “stemness,” and expression of the stem cell marker CD133. As such, ALDH activity has been proposed as a therapeutic target. Although it remains controversial which of the 19 ALDH family members drive chemotherapy resistance, ALDH1A family members have been primarily linked with chemotherapy resistant and stemness. We identified two ALDH1A family selective inhibitors (ALDH1Ai). ALDH1Ai preferentially kills CD133+ ovarian cancer stem-like cells (CSCs). ALDH1Ai induce necroptotic CSC death, mediated, in part, by the induction of mitochondrial uncoupling proteins and reduction in oxidative phosphorylation. ALDH1Ai is highly synergistic with chemotherapy, reducing tumor initiation capacity and increasing tumor eradication in vivo. These studies link ALDH1A with necroptosis and confirm the family as a critical therapeutic target to overcome chemotherapy resistance and improve patient outcomes.
Protein oxidation, nitration and glycation biomarkers for early-stage diagnosis of osteoarthritis of the knee and typing and progression of arthritic disease (2016)

Oxidized, nitrated and glycated amino acids combined with hydroxyproline and anti-CCP antibody status provided a plasma-based biochemical test of relatively high sensitivity and specificity for early-stage diagnosis and typing of arthritic disease.
Alignment of the Uniform Lying Helix Structure in Cholesteric Liquid Crystals (2009)

The uniform lying helix (ULH) configuration in cholesteric liquid crystals, where the helical axis of a chiral nematic is aligned uniformly in the plane of two confining substrates is of interest for both electro-optic and photonic applications. However, the formation of the well-aligned ULH structure required is non-trivial. Since the helical axis tends to align at an angle with respect to the surface alignment direction, cells where both substrates have planar alignment layers can cause the formation of a two-domain ULH structure. Here we investigate the orientation and nature of the domains as a function of field application. Further we show that it is possible to obtain mono-domain structures when the alignment directions on each substrate are skewed so as to match the angle that the helix forms with respect to the alignment at the electric field applied. This improves the electro-optic contrast of devices.
Chromosomal Imbalances in Germinal Center B-Cell-Like and Activated B-Cell-Like Diffuse Large B-Cell Lymphoma Influence Gene Expression Signatures and Improve Gene Expression-Based Survival Prediction(the First Two Authors Contributed Equally to This Work). (2004)

Abstract Introduction: Germinal center B-cell (GCB)-like and activated B-cell (ABC)-like diffuse large B-cell lymphomas (DLBCL) are characterized by different recurrent chromosomal imbalances. In a series of 177 untreated de novo DLBCL analyzed by comparative genomic hybridization (CGH), GCB-like DLBCL had shown more frequent gains of chromosome 12p/12cen-q14 (22% vs 5%, p=.0025), whereas ABC-like DLBCL had shown more frequent gains of 3/3q27-qter (34% vs 6%; p&amp;lt;0.0001), 18q21 (36% vs 11%;p=0.0002) and losses of 6q21-q23 (36% vs 20%; p=0.0269). We investigated the impact of chromosomal imbalances on the transcription of genes localized in the corresponding chromosomal regions, and on gene expression signatures, as previously defined (Rosenwald et al, N Engl J Med2002;346:1937–1947), as well as on survival. Results: Gains/amplifications of chromosomes 2p, 3q, 12q and 18q resulted in different gene expression patterns depending on the array-defined DLBCL subtype. For example, 18q gains/amplifications correlated with overexpression of P15RS, MADH2, MADH4, LOC51320 and PMAIP1 in GCB-like DLBCL, whereas P15RS, MIZ1, MADH2, ME2, MADH4, LOC51320, MALT1, PMAIP1, BCL2, FVT1 and NFATC1 were overexpressed in ABC-like DLBCL with 18q gains/amplifications (p&amp;lt;0.05). Chromosomal imbalances also were strongly associated with certain alterations of gene expression signatures. Gains of chromosome 7 in GCB-like DLBCL, losses of chromosome 17p13 in ABC-like DLBCL, and gains of chromosome 12 both in GCB- and ABC-like DLBCL resulted in a loss of the T-cell signature (p&amp;lt;0.001). Similarily, ABC-like DLBCL with gains of chromosome 3q but not Xp, or gains of 8q showed a loss of the lymph node signature, whereas ABC-like DLBCL with gains of Xp but not 3q showed a strong lymph node signature (p&amp;lt;0.001). Importantly, chromosomal imbalances were identified (gains of Xp, 3p, and losses of 6q13) that significantly improved the previously-defined gene expression-based outcome predictor for DLBCL patients (Rosenwald et al., NEJM, 2002). Conclusion: In GCB-like and ABC-like DLBCL, chromosomal imbalances lead to subgroup-specific overexpression of genes located within the gained/amplified regions. Chromosomal imbalances furthermore are associated with profound changes in the gene expression signatures in both GCB- and ABC-like DLBCL. Importantly, consideration of chromosomal imbalances significantly improves on the previously-defined gene expression based outcome predictors for DLBCL patients.
Nonradiative recombination and saturation of traps in multiple intrinsic quantum wells (1994)

We have investigated the dependence of the continuous-wave photoluminescence on the laser intensity, which is affected by the trap saturation and the dominant nonradiative recombination in multiple intrinsic quantum wells. If the laser intensity is relatively low, the photoluminescence is proportional to the 1.5 power of the laser intensity. As the laser intensity increases, however, and above a critical intensity, the photoluminescence increases at a rate that is higher than square-law and finally approaches this dependence. This is the result of trap saturation. In order to examine the trap saturation in a more sensitive scale, we have calculated the dependence of the effective nonradiative decay time on the laser intensity. In addition, the laser-intensity dependences of the trapping efficiency and of the ratio of the electron and hole nonradiative decay times, have been determined for different ratios of the trapping and nonradiative recombination rates. The laser-intensity dependences of the electron and hole nonradiative decay times have also been determined.
Treating Myofascial Pain and Trigger Points (1995)

No abstract available for this article.
Economics of Improved Reproductive Performance in Dairy Cattle (2019)

This fact sheet provides some estimates of the economic benefits of improved reproductive performance through increasing pregnancy rates in dairy herds. After a short literature review, the fact sheet focuses on estimates under conditions in Florida. At the herd level, the economic value of an improvement in pregnancy rate and the cost of an additional day open are estimated. This is done for both an overall increase of pregnancy rate and an increase of first service pregnancy rate. In addition, the fact sheet presents some estimates of the maximum that can be spent on a reproductive program to obtain increases in first service pregnancy rates. At the cow level, the values of a new or established pregnancy are discussed. Results show the maximum that can be spent to get specific cows pregnant. This document is AN156, one of a series of the Department of Animal Sciences, Florida Cooperative Extension Service, Institute of Food and Agricultural Sciences, University of Florida. Published August 2005.
Dietary Calcium and Risk of Microscopic Colitis (2023)

Compared with patients with diarrhea, cases with MC had a lower intake of dietary calcium. Diet can be associated with alterations in the gut microbiota and with luminal factors that could affect the risk of MC.
Dictionary learning for fast classification based on soft-thresholding (2014)

Classifiers based on sparse representations have recently been shown to provide excellent results in many visual recognition and classification tasks. However, the high cost of computing sparse representations at test time is a major obstacle that limits the applicability of these methods in large-scale problems, or in scenarios where computational power is restricted. We consider in this paper a simple yet efficient alternative to sparse coding for feature extraction. We study a classification scheme that applies the soft-thresholding nonlinear mapping in a dictionary, followed by a linear classifier. A novel supervised dictionary learning algorithm tailored for this low complexity classification architecture is proposed. The dictionary learning problem, which jointly learns the dictionary and linear classifier, is cast as a difference of convex (DC) program and solved efficiently with an iterative DC solver. We conduct experiments on several datasets, and show that our learning algorithm that leverages the structure of the classification problem outperforms generic learning procedures. Our simple classifier based on soft-thresholding also competes with the recent sparse coding classifiers, when the dictionary is learned appropriately. The adopted classification scheme further requires less computational time at the testing stage, compared to other classifiers. The proposed scheme shows the potential of the adequately trained soft-thresholding mapping for classification and paves the way towards the development of very efficient classification methods for vision problems.
ChemInform Abstract: DIE 5‐METHOXYLIERUNG EINES OXINDOL‐DERIVATES (1972)

Abstract 1‐Hydroxy‐oxindol (I) reagiert mit p‐Toluolsulfonylchlorid bei ‐78°C zum instabilen Sulfonat (IIa), das sich bei Raumtemperatur in die in 7‐Stellung substituierte Verbindung umlagert.
Seismic Random Noise Separation and Attenuation Based on MVMD and MSSA (2021)

Seismic noise separation and attenuation is a fundamental topic in the seismic signal processing and geological interpretation. Several kinds of algorithms are proposed for separating and attenuating seismic random noises. However, the conventional methods often handle a seismic volume trace by trace, which ignores the lateral continuity of seismic data. Moreover, seismic signal is a typical broadband signal, which makes it difficult to separate and attenuate random noises contained in the whole frequency bands of the raw seismic data. Additionally, the tuning parameters for the denoising methods are also a difficult task to filter a broadband seismic signal. In this study, we propose a multi-channel scheme which is referred as the multi-channel variational mode decomposition (MVMD) based on multi-channel singular spectrum analysis (MSSA), to efficiently and effectively separate and attenuate seismic random noises. The proposed workflow first adopts the MVMD to decompose a 2-D seismic data into several band-limited intrinsic mode functions (IMFs) with different center frequencies and different bandwidths. Then, we leverage the MSSA for each decomposed IMF to separate and attenuate random noises. It is worth to be noted that we can select the tuning MSSA parameters for each IMF based on their different center frequencies and bandwidths. Finally, we restore the valid seismic data by summing all filtered IMFs. Through detailed comparisons with the traditional denoising methods, the results from the synthetic examples and field data quantitatively and qualitatively demonstrate the effectiveness and accuracy of the proposed workflow for separating and attenuating seismic random noises.
Printed dry electrode for neuromuscular electrical stimulation (NMES) for e-textile (2023)

Muscle atrophy is a well-known consequence of immobilization and critical illness, leading to prolonged rehabilitation and increased mortality. In this study, we develop a solution to preserve muscle mass using customized biocompatible neuromuscular electrical stimulation (NMES) device. Commercially available NMES solutions with gel-based electrodes often lead to skin irritation. We demonstrate the printing of conducting electrodes on a compressive stocking textile that can be used for more than seven days without observing any inflammation. This solution consists of a dry and biocompatible electrode directly integrated into the textile with good mechanical compatibility with skin (Young's modulus of 0.39 MPa). The surface roughness of the underlying substrate plays a significant role in obtaining good print quality. Electrochemical Impedance Spectroscopy (EIS) analysis showed that the printed electrode showed better performance than the commercial ones based on a matched interfacial performance and improved series resistance. Furthermore, we investigated our NMES solution in a hospital setting to evaluate its effectiveness on muscle atrophy, with promising results.