gebhart/patrepeval huggingface dataset:
Isotactic polymerization of .alpha.-olefins: stereoregulation for different reactive chain ends (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIsotactic polymerization of .alpha.-olefins: stereoregulation for different reactive chain endsA. Zambelli, M. C. Sacchi, P. Locatelli, and G. ZannoniCite this: Macromolecules 1982, 15, 1, 211–212Publication Date (Print):January 1, 1982Publication History Published online1 May 2002Published inissue 1 January 1982https://pubs.acs.org/doi/10.1021/ma00229a043https://doi.org/10.1021/ma00229a043research-articleACS PublicationsRequest reuse permissionsArticle Views174Altmetric-Citations93LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effects of pH on Membrane Fluidity of Human Erythrocytes (1982)

The effects of pH on the membrane fluidity of intact human erythrocytes, ghosts, and their lipid vesicles were studied by spin label techniques in the range of pH 3.0 to 9.1. Two fatty acid spin labels, 5-nitroxide stearic acid (5NS) and 12-nitroxide stearic acid (12NS), and a maleimide spin label were used for the labeling of the membrane lipids and proteins, respectively. The outer hyperfine splitting (T parallel) was measured as a parameter of membrane fluidity. In the case of 5NS, the T parallel values for intact erythrocytes and ghosts remained almost constant over the entire pH range at 22 degrees C but those for their lipid vesicles changed slightly, indicating the vertical displacement of the labels in lipid bilayers. On the other hand, the ESR spectra of 12NS incorporated into intact erythrocytes and ghosts, as compared with their lipid vesicles, showed marked pH dependence. By means of spin labeling of membrane proteins, the conformational changes of the proteins were observed in the pH range mentioned above. These results suggest a possible association between the strong pH dependence of the T parallel values and the conformation changes of membrane proteins. The pH dependence of the membrane fluidity was also investigated in cholesterol-enriched and -depleted erythrocytes. The effects of cholesterol demonstrated that the membrane fluidity was significantly mediated by cholesterol at low pH, but not at high pH.
Slat collimated multipinhole human brain SPECT (2008)

A new brain SPECT system based on multipinhole collimation has been designed and the properties have been studied with Monte Carlo simulations. Results show the system has better resolution and acceptable sensitivity compared to commercial SPECT systems.
Guidelines for Stable Operation of a Polymer Electrolyte Fuel Cell with Self-Humidifying Membrane Electrolyte Assembly (2007)

The desired performance of a polymer electrolyte fuel cell is always hindered by mismatching of operating conditions (such as temperature, flow rates of fuel and oxidant, level of humidification of reactants, etc.) with parameters associated with the cell performance (such as electrolyte conductivity, net back diffusion of water behavior in the membrane electrolyte assembly, etc.). This paper presents some design guidelines for polymer electrolyte fuel cells by establishing relationships among critical parameters of the fuel cell and is particularly useful for the developmental stage of mini/microfuel cells operating under nonpressurized condition and without external humidification of fuel.
Clinical implications of the loss of vasoactive nitric oxide during red blood cell storage (2007)

According to Pelis (1), “Blood is one of man's most compelling and omnipresent symbols. It signifies the opposition between life and death, health and sickness, power and powerlessness.” Blood and RBC transfusion, even done autologously, is a well proven treatment that, like the administration of aspirin, had never undergone the kind of rigorous, controlled clinical trials now required by the U.S. Food and Drug Administration.
Changing faces: two years on (1994)

Reconstructive plastic surgery and medicine have made great strides in recent years. Advances mean that scarring, evidence of injury, and various abnormalities can be reduced in conspicuousness and sometimes even removed, for example, the use of laser treatment for port wine stains. Contrary to the Hollywood myth, however, in which people involved in horrific accidents are restored to their former glory, plastic surgery is not a 'miracle cure'. Disfigurement is rarely temporary: most are left disfigured for life.
Quercitrin Stimulates Hair Growth with Enhanced Expression of Growth Factors via Activation of MAPK/CREB Signaling Pathway (2020)

The present study aimed to investigate the molecular mechanism of quercitrin, a major constituent of <i>Hottuynia cordata</i> extract, for its hair growth stimulating activities in cultured human dermal papilla cells (hDPCs). Quercitrin enhanced the cell viability and cellular energy metabolism in cultured hDPCs by stimulating the production of NAD(P)H and mitochondrial membrane potential (ΔΨ). The expression of Bcl2, an essential marker for anagen hair follicle and cell survival, was increased by quercitrin treatment. Quercitrin also increased the cell proliferation marker Ki67. The expression of growth factors-such as bFGF, KGF, PDGF-AA, and VEGF-were increased by quercitrin both in mRNA and protein levels. In addition, quercitrin was found to increase the phosphorylation of Akt, Erk, and CREB in cultured hDPCs, while inhibitors of MAPKs reversed the effects of quercitrin. Finally, quercitrin stimulated hair shaft growth in cultured human hair follicles. Our data obtained from present study are in line with those previously reported and demonstrate that quercitrin is (one of) the active compound(s) of <i>Hottuynia cordata</i> extract which showed hair growth promoting effects. It is strongly suggested that the hair growth stimulating activity of quercitrin was exerted by enhancing the cellular energy metabolism, increasing the production of growth factors via activation of MAPK/CREB signaling pathway.
Design and testing of CRBRP insulated horizontal and vertical pipe clamps (1980)

The Clinch River Breeder Reactor Plant (CRBRP) Primary Heat Transport system piping may be characterized as large-diameter, thin-wall piping which transports liquid sodium at high temperatures. The piping is arranged in accord with the elevated loop concept, consisting of large horizontal inplane, expansion loops and long, vertical runs of piping. These characteristics and the postulated thermal transient and seismic loads, which are imposed on the piping, dictate pipe clamp designs that are substantially different from standard off the shelf pipe clamp designs. The design features of the CRBRP horizontal and vertical pipe clamps for the large sodium piping, the various test programs used to verify the clamp designs, and the results of this testing are presented.
Oxidation of Carbon Fibers in Water Vapor Studied (2003)

T-300 carbon fibers (BP Amoco Chemicals, Greenville, SC) are a common reinforcement for silicon carbide composite materials, and carbon-fiber-reinforced silicon carbide composites (C/SiC) are proposed for use in space propulsion applications. It has been shown that the time to failure for C/SiC in stressed oxidation tests is directly correlated with the fiber oxidation rate (ref. 1). To date, most of the testing of these fibers and composites has been conducted in oxygen or air environments; however, many components for space propulsion, such as turbopumps, combustors, and thrusters, are expected to operate in hydrogen and water vapor (H2/H2O) environments with very low oxygen contents. The oxidation rate of carbon fibers in conditions representative of space propulsion environments is, therefore, critical for predicting component lifetimes for real applications. This report describes experimental results that demonstrate that, under some conditions, lower oxidation rates of carbon fibers are observed in water vapor and H2/H2O environments than are found in oxygen or air. At the NASA Glenn Research Center, the weight loss of the fibers was studied as a function of water pressure, temperature, and gas velocity. The rate of carbon fiber oxidation was determined, and the reaction mechanism was identified.
Distal Ulcerative Colitis Refractory to Rectal Mesalamine: Role of Transdermal Nicotine versus Oral Mesalamine (2002)

The addition of transdermal nicotine to treatment with mesalamine enemas is significantly superior to combined therapy with oral and rectal mesalamine in patients with distal ulcerative colitis refractory to rectal mesalamine alone.
Diagnosis and treatment of vascular brain-stem malformations (1990)

Vascular malformations are a common cause of spontaneous brain-stem hemorrhage in young normotensive individuals. These lesions are no longer cryptic. Magnetic resonance (MR) imaging has renewed interest in the treatment of this disorder because of the precise accuracy in diagnosis and localization of these lesions that it affords. The MR image demonstrates characteristic findings of multiple hemorrhages of varying ages surrounded by a hypointense peripheral zone of hemosiderin. Five cases of vascular brain-stem malformation diagnosed with MR imaging are described. The vascular malformations could be demonstrated as "flow void" areas in three cases. Three patients were treated surgically and vascular malformations were confirmed: all three patients improved postoperatively. Two patients were treated nonsurgically; one of these recovered from a second hemorrhage and the other experienced neurological deterioration after a single hemorrhage. High-energy radiotherapy was not effective for the one vascular malformation treated by this method. This experience suggests that surgical exploration should be considered for vascular brain-stem malformations when the diagnosis is confirmed by MR criteria and the clinical course and lesion are both progressive in character.
Nurse-like cells mediate ibrutinib resistance in chronic lymphocytic leukemia patients (2015)

International audience
Broken Machines or Active Bodies? Part 3. Five Recommendations to Shift the Way Clinicians Communicate With People Who Are Seeking Care for Osteoarthritis (2023)

<b>SYNOPSIS:</b> In parts 1 and 2 of this series, we highlighted the dominant impairment way of talking about osteoarthritis: talking that frames osteoarthritis as a disease of cartilage worsened by physical activity that can only be "cured" by replacing the joint. An alternative understanding that counters common misconceptions about osteoarthritis, and links physical activity and healthy lifestyles to improvements in symptoms is likely a prerequisite for sustainable behavior change. It is insufficient to tell people with osteoarthritis that regular physical activity is important; people need to understand and experience <i>how</i> physical activity can help. Here, we offer suggestions for how clinicians can shift from focusing on what people cannot do because of osteoarthritis, toward focusing on what people <i>can</i> do to improve their health and maintain "active bodies." <i>J Orthop Sports Phys Ther 2023;53(7):1-6. doi:10.2519/jospt.2023.11881</i>.
Barriers to prenatal detection of congenital heart disease: a population‐based study (2011)

The majority of CHD cases over the 10-year study period were missed prenatally and detection rates did not increase materially during that time. The failure to detect CHD prenatally was related to encounter characteristics, specifically involving screening ultrasound examinations, which may be targeted for improvement.
Support system, excavation arrangement, and process of supporting an object (2023)

A support system, an excavation arrangement, and a process of supporting an object are disclosed. The support system includes a weight-bearing device and a camming mechanism positioned below the weight-bearing device. A downward force on the weight-bearing device at least partially secures the camming mechanism to opposing surfaces. The excavation arrangement includes a borehole, a support system positioned within and secured to the borehole, and an object positioned on and supported by the support system. The process includes positioning and securing the support system and positioning the object on the weight-bearing device.
Correction: Towards a Rigorous Assessment of Systems Biology Models: The DREAM3 Challenges (2010)

Conclusions: DREAM provides valuable feedback to practitioners of systems biology modeling. Lessons learned from the predictions of the community provide muchneeded context for interpreting claims of efficacy of algorithms described in the scientific literature.
Liquid Chromatographic Behavior of Selected Aza-arenes and Potential Metabolites (1984)

Abstract Reversed phase HPLC was applied to analyses of selected aza-arenes and potential metabolites (5,6-benzoquinoline, 5,6-benzoquinoline-N-oxide, and the N-methyliodide salt of 5,6-benzoquinoline). Naphthalene and anthracene were employed as reference materials. Water-methanol and ammonium phosphate-methanol mobile phases were used with several commercial octadecyl reversed phase columns and a column using laboratory synthesized ODS stationary phase. Chromatographic behavior of the hydrocarbon reference compounds were excellent on all packings with either mobile phase. Benzoquinoline and derived materials were more difficult analytical subjects; water-methanol mobile phases proved unsuitable giving very long retention times with unacceptable efficiencies. Ammonium phosphate containing mobile phases were more appropriate for the nitrogen containing materials especially when used with end capped or polymeric end capped stationary phases.
<title>Experimental investigation on the statistical properties of speckle recorded by a CCD camera</title> (1996)

Hohai UniversityDepartment of Physics and MathematicsNanjing, Jiangsu, 210024, ChinaABSTRACTThis paper reports an experimental investigation on the statistical properties of laser speckle recorded byusing a CCD camera under different F numbers. Statistical properties such as the probability densityfunction of the intensity of the laser speckle varies with the F number of the optical set-up for different mparameters were analysed and compared with the theoretical predication.Keywords: laser speckle, statistical properties, CCD camera, F number1. INTRODUCTIONCCD image sensors have become important tools in digital ESPI. In such a system, laser speckle patternis imaged through an optical set-up onto a CCD detector array and then sampled and digitised into PCcomputer. It is of concern that the statistical properties of the laser speckle be under the influence of the F
Designing and validating a measure of moral judgment: Stage preference and stage consistency approaches. (1997)

The Defining Issues Test (DIT) of moral judgment is discussed in light of the recent challenge by G. Lind (1995) with the Moral Judgment Test (MJT), which is widely used in Europe. The 2 tests represent alternative methods as well as support different conclusions about moral judgment. The key difference is a stage-consistency (MJT) vs. a stage-preference (DIT) approach. Construct validity is defined in terms of 7 types of studies, and the approaches are compared. The stage-preference approach systematically outperforms the stage-consistency approach. Benchmarking by using classic studies in moral judgment illustrates an empirical, multistudy, quantitative approach to moral judgment research.
<title>Interactive system for classifying multispectral images using a Hilbert curve</title> (1995)

There are several techniques for analyzing multispectral images. In general, those are performed by linear transformation methods. In this paper, we present a new interactive method for classifying multispectral images using a Hilbert curve which is a one-to-one mapping from N- dimensional space to one dimensional space and preserves the neighborhood as much as possible. The merit of our system is that the user can extract clusters without computing any distance in N- dimensional space, and analyze multidimensional data from gross data distribution to fine data distribution hierarchically. In the experiments using LANDSAT TM data, it is confirmed that the user can get the real time response from the system after once making the data tables, and understand distribution of data that correspond to categories in feature space.
Supplementary Figure Legend, Table 1 from Nonclinical Evaluation of the Serum Pharmacodynamic Biomarkers HGF and Shed MET following Dosing with the Anti-MET Monovalent Monoclonal Antibody Onartuzumab (2023)

&lt;p&gt;PDF file - 76K, Supplemental Table 1: Oligonucleotide sequences.&lt;/p&gt;
Regulation of the Human Chorionic Gonadotropin α- and β-Subunit Promoters by AP-2 (1997)

Production of the placental hormone, chorionic gonadotropin (CG), increases dramatically as cytotrophoblasts fuse to form syncytiotrophoblasts. The CG alpha- and beta-promoters are both responsive to cAMP, although the kinetics of cAMP stimulation are different. In an effort to understand the mechanisms of coordinate induction of these genes, AP-2 binding sites were identified in the promoter regions of the alpha and CGbeta genes. AP-2 bound to the upstream regulatory element (-186 to -156 base pairs (bp)) in the alpha-promoter and to several different regions of the CGbeta promoter, including footprints 2 and 4B (FP2, -311 to -279 bp; FP4B, 221 to -200 bp). AP-2 antibodies induced supershifts of these complexes, confirming the identity of the protein-DNA complex. In JEG-3 cells, which contain abundant AP-2, mutations in these CGbeta AP-2 sites reduced basal activity and decreased cAMP stimulation. In AP-2-deficient Hep-G2 cells, co-transfection of AP-2 stimulated expression of the CGbeta promoter 10-20-fold, and the alpha-promoter was induced by 3-6-fold. Mutations that eliminate AP-2 binding to CGbeta FP4B reduced AP-2 stimulation by more than 80%, whereas mutations in FP2 reduced AP-2 stimulation by less than 50%. Analyses of AP-2 mutants revealed a requirement for the DNA binding/dimerization domain and the amino-terminal proline-rich and acid-rich transactivation domains for stimulation of the CGbeta promoter. Primary cultures of placental cytotrophoblasts were differentiated into syncytiotrophoblasts in vitro to examine AP-2 expression by reverse transcriptase-polymerase chain reaction. AP-2 mRNA levels increased by day 2 and continued to rise in parallel with a marked increase in alpha and CGbeta gene expression. We conclude that both the alpha and CGbeta promoters contain binding sites for AP-2 and suggest that this transcription factor provides a mechanism for coordinating the induction of these genes during placental cell differentiation.
How to Evaluate Class III Antiarrhythmic Drug Efficacy Clinically (1992)

Ventricular tachycardia and ventricular fibrillation are frequent complications of organic heart disease. There is sufficient evidence that serial electrophysiologic testing is able to predict long-term efficacy of antiarrhythmic agents in patients with malignant ventricular tachyarrhythmias. This approach has not only been useful for the evaluation of class I drugs, but recent studies have shown that this invasive method may also be useful for the management of patients undergoing treatment with class III antiarrhythmic agents such as amiodarone and sotalol. The results of several studies suggest that class III agents are more effective than class I drugs in patients presenting with ventricular tachycardia or ventricular fibrillation. Proarrhythmic complications in patients treated with class III antiarrhythmic drugs are mainly characterized by torsades de pointes. Their incidence does not exceed 5%. Further studies are necessary to elucidate the mechanisms underlying this type of proarrhythmia. By the use of currently available stimulation techniques, patients who might develop torsades de pointes while on therapy with a class III agent cannot be identified.
Ground-Free ECG Recording with Two Electrodes (1980)

ECG recordings normally use three electrodes-two for the differential inputs of the ECG amplifier and the third for ground. We analyze those situations where the ground electrode can be eliminated. We propose a model for the source of electrical interference and determine various parameter values. Making use of experimentally obtained data for the model parameters we suggest optimal design for a two-electrode amplifier. The two-electrode design is useful for biotelemetry, portable Holter monitors, and portable arrhythmia monitors. Under certain circumstances it may be useful for grounded monitoring equipment. The two-electrode technique has the advantage that it improves patient safety by eliminating the ground electrode. Fewer electrodes make patient attachment easier and lower electrode costs.
The Role of PIEZO2 in Human Mechanosensation (2016)

Our results show that PIEZO2 is a determinant of mechanosensation in humans. (Funded by the National Institutes of Health Intramural Research Program.).
Analysis of iterative region-of-interest image reconstruction for x-ray computed tomography (2014)

One of the challenges for iterative image reconstruction (IIR) is that such algorithms solve an imaging model implicitly, requiring a complete representation of the scanned subject within the viewing domain of the scanner. This requirement can place a prohibitively high computational burden for IIR applied to x-ray computed tomography (CT), especially when high-resolution tomographic volumes are required. In this work, we aim to develop an IIR algorithm for direct region-of-interest (ROI) image reconstruction. The proposed class of IIR algorithms is based on an optimization problem that incorporates a data fidelity term, which compares a derivative of the estimated data with the available projection data. In order to characterize this optimization problem, we apply it to computer-simulated two-dimensional fan-beam CT data, using both ideal noiseless data and realistic data containing a level of noise comparable to that of the breast CT application. The proposed method is demonstrated for both complete field-of-view and ROI imaging. To demonstrate the potential utility of the proposed ROI imaging method, it is applied to actual CT scanner data.