gebhart/patrepeval huggingface dataset:
Long-term treatment of endometriosis with dienogest for up to five years (2019)

Purpose of Investigation: Dienogest is marketed in Japan as the first time in the world for novel treatment of endometriosis. This paper details the retrospective investigation how effective long-term use of dienogest is for the treatment of endometriosis. Materials and Methods: Data on 21 patients of diagnosed as endometriosis/adenomyosis and treated with dienogest for more than 12 months (ten patients with 60-month period) were collected. Results: Dienogest was effective in reducing pain and size of ovarian endometrioma, while the size of adenomyosis remained the same size as before treatment. The most frequent adverse effects were irregular bleeding. There was no reduction in bone mineral density after 60 months while plasma estradiol was maintained at a slightly lower level. Clinical parameters for did not change during a 60-month period. Conclusions: These results show that dienogest is safe to use for at least five years and is an effective treatment for endometriosis for long periods.
Observation of halos in rotationally inelastic scattering of Na2 from Ar (1980)

We have measured level to level differential cross sections for rotational level changing collisions in ground state Na2 with Ar: Na2 (v\=0, ji=7)+Ar→Na2 (v\=0, jf)+Ar. Measurements range in Δj(jf−ji) from −4 to 80 and in Θ to π. A seeded supersonic beam source produces rotationally cold Na2 with a narrow velocity distribution; the levels are isolated and the differential cross sections are measured with cw dye lasers, using a new technique, angular distributions using the Doppler shift. The differential cross sections display a sharp rise and slow decline, reaching a maximum at an angle which is roughly proportional to Δj. We term these features ’’halos’’. (AIP)
Search for Gluino and Squark Cascade Decays at the Fermilab Tevatron Collider (1996)

We report on a search for supersymmetry using dilepton events which complements the classic missing ${E}_{T}$ plus multijet analyses. Using $19{\mathrm{pb}}^{\ensuremath{-}1}$ of $p\overline{p}$ collisions at $\sqrt{s}\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}1.8\mathrm{TeV}$ recorded with the Collider Detector at Fermilab we have searched for squarks and gluinos decaying into charginos and producing events with two leptons. We observe one candidate event. In comparison, the expected number of background events from standard model processes is $2.39\ifmmode\pm\else\textpm\fi{}0.63(\mathrm{stat}{)}_{\ensuremath{-}0.42}^{+0.77}(\mathrm{syst})$. Hence we set limits on gluino and squark production based on predictions from the supergravity inspired minimal supersymmetric extension of the standard model.
Introduction to the Use of Robotic Tools for Search and Rescue (2017)

Modern search and rescue workers are equipped with a powerful toolkit to address natural and man-made disasters. This introductory chapter explains how a new tool can be added to this toolkit: robots. The use of robotic assets in search and rescue operations is explained and an overview is given of the worldwide efforts to incorporate robotic tools in search and rescue operations. Furthermore, the European Union ICARUS project on this subject is introduced. The ICARUS project proposes to equip first responders with a comprehensive and integrated set of unmanned search and rescue tools, to increase the situational awareness of human crisis managers, such that more work can be done in a shorter amount of time. The ICARUS tools consist of assistive unmanned air, ground, and sea vehicles, equipped with victim-detection sensors. The unmanned vehicles collaborate as a coordinated team, communicating via ad hoc cognitive radio networking. To ensure optimal human-robot collaboration, these tools are seamlessly integrated into the command and control equipment of the human crisis managers and a set of training and support tools is provided to them to learn to use the ICARUS system.
Air Flow Through Hinged Baffle Slotted Inlets (1976)

ABSTRACT ADIMENSIONAL analysis approach is used to obtain an equation predicting the air flow rate through a hinged baffle slotted inlet as a function of slot width, baffle angle, and inlet static pressure differential. Simplifying assumptions are introduced to obtain a prediction method which will be convenient to use in slotted inlet design procedures. A comparison of the results from the locally fabricated slotted inlet and a commercially available inlet system is made and shows the two to be in close agreement. Results obtained from the commercial inlet show a significant difference in air delivery capacity depending on whether the incoming air changes direction within the inlet. A change of direction substantially reduces the flow rate.
Requirements for antigenic competition in contact sensitivity. (1990)

The requirements for the induction of antigenic competition in murine contact sensitivity have been examined. Experiments with a variety of skin-sensitizing chemicals revealed a correlation between immunogenicity and the ability to inhibit subsequent responses to an unrelated contact allergen, oxazolone. Previous studies have suggested that, in contact sensitivity at least, antigenic competition is the consequence of a reduced lymphocyte proliferative response to the second antigen. We investigated whether the regulatory events which impair proliferation following exposure to the second antigen are induced as the result of a strong proliferative response to the first (competitor) antigen. It was found, however, that significant inhibition of the primary proliferative response to picryl chloride, by pretreatment of mice with either picryl sulphonic acid or 2,4-dinitrochlorobenzene, failed to prevent picryl chloride inducing antigenic competition for oxazolone. Our studies suggest that following topical exposure to potent skin allergens events other than proliferation in draining lymph nodes induce active immunoregulatory processes, one consequence of which is the appearance of antigenic competition.
Statistical aspects of NBTI/PBTI and impact on SRAM yield (2011)

Quantitative simulations of the statistical impact of negative-bias-temperature-instability (NBTI) on pMOSFETs, and positive-bias-temperature-instability (PBTI) on nMOSFETs are carried out for a 45nm low power technology generation. Based on the statistical simulation results, we investigate the impact of NBTI and PBTI on the degradation of the static noise margin (SNM) of SRAM cells. The results indicate that SNM degradation due only to NBTI follows a different evolution pattern compared with the impact of simultaneous NBTI and PBTI degradation.
Ammonia and Ammonium Reactions with Some Layer‐Silicate Minerals (1964)

Abstract Retention of NH 3 and fixation of NH 4 + by 16 specimen layer‐silicate minerals was investigated using anhydrous and aqua NH 3 , NH 4 Cl, and different degassing and fixing conditions. Despite a much greater partial pressure differential, vacuum degassing (to remove excess and physically sorbed NH 3 ) greatly accentuated the retention and apparent NH 3 fixation as compared with diffusion degassing. The great bulk of NH 3 initially sorbed by anhydrous NH 3 ‐treated layer‐silicates was rapidly dissipated (few hours to &lt; 3 days) when samples were exposed to the atmosphere. Redisplacement by competitive water vapor evidently was a principal driving force. The equivalent of tons of NH 3 per acre‐furrow‐slice, however, was retained longer than 3 days by the expandable layer‐silicates. The major portion (68 to 99+%) of retained NH 3 was KCl leachable in all except the vermiculitic samples in which &gt; 90% was fixed. Wide variability in basal spacing changes resulted from ammoniation and wetting treatments. Physical changes as reflected by X‐ray diffraction were in general accord with chemical data. Vermiculitic minerals under wet or air‐dry conditions fixed quantities of NH 4 + greatly in excess of amounts fixed by other minerals. Metabentonite 38 and biotite 33 fixed moderate quantities under these conditions. In a comparison of N sources under wet fixing conditions, less than 20% as much N was fixed by vermiculite from aqua NH 3 as from NH 4 Cl. All other minerals fixed roughly equivalent amounts from both sources. Montmorillonites fixed very small quantities of NH 3 or NH 4 + under wet or air‐dry conditions but showed a roughly 20‐fold increase in NH 4 + fixation resulting from drying at 105°C. Anomalous retention and mechanisms of NH 3 retention and fixation are briefly discussed. Results re‐emphasized need for continued restraint to minimize overextrapolation of data from a few type minerals to complex mixtures as generally encountered in soils.
Differences and Similarities of Epothilones (2011)

Epothilones are a novel class of natural cytotoxic compounds, originally isolated from the myxobacterium Sorangium cellulosum in the early 1990s. They induce hyperstabilization of microtubules similar to the taxanes leading to cell cycle arrest and finally to apoptosis. The natural epothilones are characterized by the letters A – F. Their chemical structure consists of a 16-membered macrocyclic ring system with a common side chain that differs in its oxydation status. Currently, natural epothilones, such as epothilone B (patupilone) and D (KOS-862), semisynthetic (ixabepilone, BMS-310705) and fully synthetic epothilones (sagopilone and KOS-1584) are in clinical development. Whereas paclitaxel and docetaxel provide significant clinical benefit in the treatment of a number of tumor types, their use is often limited by the development of multidrug resistance. Preclinical results indicate that natural epothilones are not subject to multidrug resistance to the same extent as the taxanes. Whether this translates into additional clinical benefit is currently the objective of extensive investigations. Ixabepilone, like the taxanes a substrate for PgP, has recently been approved for the treatment of metastatic breast cancer in the USA. However, the European agency CHMP declined a positive opinion due to an insufficient benefit /risk ratio. Other epothilones are in different stages of development, the most advanced being patupilone in Phase III in ovarian cancer and sagopilone in Phase II in a number of different tumor types. Although their mechanism of action is identical and their chemical structures are very similar, epothilones exhibit a highly differentiated picture of activity, safety and tolerability profiles. For ixabepilone, the major adverse event is hematological toxicity followed by peripheral sensory neuropathy. Patupilone, on the other hand, is mainly characterized by gastrointestinal side effects, which require pretreatment and concomitant therapy. In the case of sagopilone, peripheral sensory neuropathy is the major clinically relevant side effect. This review summarizes both preclinical and clinical results for the epothilones currently in clinical development. Keywords: Epothilones, cytotoxic drugs, oncology, microtubular inhibitors, multidrug resistance, clinical development, Microtubules, equilibrium, ovarian cancer, -tubulin, paclitaxel, potency, anti-cancer drugs, neurotoxicity, lactone ring system, bioavailability, ixabepilone, sagopilone, benzene ring, ketone, lipophilicity, water-soluble, heterozygous impairment, pancreatic tumor, brain tumor growth, infusion, single-agent studies, neutropenia, fatigue, sensory neuropathy, nausea, vomiting, dose, mucositis, ileus, diarrhea, ovarian, primary fallopian, ataxia, neuropathy, hyponatremia, chest pain, half-life, plasma level, urine, metabolites, germ cell, sarcoma, melanoma, thrombocytopenia, breast cancer, doxorubicin
Reduced Order Impedance Models of Lithium Ion Batteries (2014)

This paper develops reduced order, linear models of lithium ion batteries that can be used for model-based power train simulation, design, estimation, and controlling in hybrid and electric vehicles (HEV). First, a reduced order model is derived from the fundamental governing electrochemical charge and Li+ conservation equations that are linearized at the operating state of charge and low current density. The equations are solved using analytical and numerical techniques to produce the transcendental impedance or transfer function from input current to output voltage. This model is then reduced to a low order state space model using a system identification technique based on least squares optimization. Given the prescribed current, the model predicts voltage and other variables such as electrolyte and electrode surface concentration distributions. The second model is developed by neglecting electrolyte diffusion and modeling each electrode with a single active material particle. The transcendental particle transfer functions are discretized using a Padé Approximation. The explicit form of the single particle model impedance can be realized by an equivalent circuit with resistances and capacitances related to the cell parameters. Both models are then tuned to match experimental electrochemical impedance spectroscopy (EIS) and pulse current-voltage data.
ChemInform Abstract: 4,4′‐ISOPROPYLIDEN‐DIPHENOL‐MONOCARBONSAEUREN ALS BASIS VON RESOLCARBONSAEUREN FUER WASSERLOESLICHE KUNSTHARZBINDEMITTEL (1973)

Abstract Durch Umsetzung des Diols (Ia) mit Chloressigsäure, β‐Chlorpropionsäure bzw. Acrylnitril in alkalischer Lösung wurden die Säuren (Ib) und (Ic) sowie das Nitril (Id) dargestellt, neben denen jeweils (in durch geeignete Reaktionsbedingungen klein gehaltenen Mengen) die entsprechenden symmetrischen Äther anfielen.
Multi-Resolution A* (2020)

Heuristic search-based planning techniques are commonly used for motion planning on discretized spaces. The performance of these algorithms is heavily affected by the resolution at which the search space is discretized. Typically a fixed resolution is chosen for a given domain. While a finer resolution allows for better maneuverability, it significantly increases the size of the state space, and hence demands more search efforts. On the contrary, a coarser resolution gives a fast exploratory behavior but compromises on maneuverability and the completeness of the search. To effectively leverage the advantages of both high and low resolution discretizations, we propose Multi-Resolution A* (MRA*) algorithm, that runs multiple weighted-A*(WA*) searches having different resolution levels simultaneously and combines the strengths of all of them. In addition to these searches, MRA* uses one anchor search to control expansions from these searches. We show that MRA* is bounded suboptimal with respect to the anchor resolution search space and resolution complete. We performed experiments on several motion planning domains including 2D, 3D grid planning and 7 DOF manipulation planning and compared our approach with several search-based and sampling-based baselines.
Supplementary Data from Active Remodeling of Capillary Endothelium via Cancer Cell–Derived MMP9 Promotes Metastatic Brain Colonization (2023)

&lt;p&gt;Supplementary Figures and Figure legends, Supplementary Video legends and supplementary materials and methods&lt;/p&gt;
Use of Integra® Artificial Skin Is Associated With Decreased Length of Stay for Severely Injured Adult Burn Survivors (2002)

Mortality and length of stay (LOS) of survivors was examined retrospectively in 270 adults with acute burns > or =20% of body surface area to determine the effect of Integra Dermal Regeneration Template treatment on outcome. No difference in mortality was found between patients who received Integra (30%; n = 43) and patients who did not (30%; n = 227). Surviving Integra patients (n = 30) stayed longer, but they were more extensively injured than survivors who did not receive Integra (n = 158), and therefore longer hospitalizations were expected. In a subgroup analysis, mean LOS of Integra patients with two or more mortality risk factors (age > 60 years, burn size >40% body surface area, or inhalation injury; n = 15) was 63 days compared with 107 days in patients with two or more risk factors (n = 29) who did not receive Integra ( =.014). Integra use in severely injured burned adults was associated with a marked decrease in LOS.
for CD4+ T Cell-Mediated Antiviral Qualitative and Quantitative Requirements (2013)

Rolf M. Zinkernagel and Hans HengartnerTheofilopoulos, Burkhard Ludewig, Urs Hoffmann-Rohrer,Rulicke, Hanspeter Pircher, Dwight H. Kono, Argyrios N. Kevin J. Maloy, Christoph Burkhart, Giulia Freer, Thomashttp://www.jimmunol.org/content/162/5/2867J Immunol€1999; 162:2867-2874; ;Referenceshttp://www.jimmunol.org/content/162/5/2867.full#ref-list-1This article cites 66 articles, 43 of which you can access for free at: Subscriptionshttp://jimmunol.org/subscriptionsInformation about subscribing to The Journal of Immunology is online at: Permissionshttp://www.aai.org/ji/copyright.htmlSubmit copyright permission requests at: Email Alertshttp://jimmunol.org/cgi/alerts/etocReceive free email-alerts when new articles cite this article. Sign up at:
Durability and Long Term Performance of Engineered Cementitious Composites (2006)

Peer Reviewed
Measurement of topographic phase image of living cells by white-light phase-shifting microscope with active stabilization of optical path difference (2007)

We report a full-field, phase-shifting microscope with precise control of the optical path difference (OPD) and show
topographic phase images of living cells. Our system is based on a Linnik interference microscope with Kohler
illumination of a halogen lamp for the imaging lightsource. Phase-sensitive active-stabilization of the OPD is employed
with an infrared laser whose optical path is the same as that of halogen light. We previously reported the results of
cultured cell topography with this stabilization scheme; however the phase stability and the image quality were
insufficient. We have improved the noise-cancellation system and achieved control of the OPD with stability down to
0.7 nm in the bandwidth of 500 Hz. Quarter wavelength phase-shifting was carried out with sub-nanometer accuracy,
and clear topographic phase images of cultured single-layer cells were obtained. The Kohler illumination with the
halogen lamp, whose coherence length is 2 mm, enables homogenous illumination and suppression of artifact signals
arising from optical components not associated with the surface of interest.
Development of the Varioscope AR. A see-through HMD for computer-aided surgery (2002)

In computer-aided surgery (CAS), an undesired side-effect of the necessity of handling sophisticated equipment in the operating room is the fact that the surgeon's attention is drawn from the operating field, since surgical progress is partially monitored on the computer's screen. Augmented reality (AR), the overlay of computer-generated graphics over a real-world scene, provides a possibility to solve this problem. The technical problems associated with this approach, such as viewing of the scenery within a common focal range on the head-mounted display (HMD) or latency in the display on the HMD, have, however, kept AR from widespread usage in CAS. The concept of the Varioscope AR, a lightweight head-mounted operating microscope used as a HMD, is introduced. The registration of the patient to the pre-operative image data, as well as pre-operative planning, take place on VISIT, a surgical navigation system developed at our hospital. Tracking of the HMD and stereoscopic visualisation take place on a separate POSIX.4-compliant real-time operating system running on PC hardware. We were able to overcome the technical problems described above; our work resulted in an AR visualisation system with an update rate of 6 Hz and a latency below 130 ms. It integrates seamlessly into a surgical navigation system and provides a common focus for both virtual and real-world objects. First evaluations of the photogrammetric 2D/3D registration have resulted in a match of 1.7 pixels on the HMD display. The Varioscope AR with its real-time visualisation unit is a major step towards the introduction of AR into clinical routine.
ChemInform Abstract: SYNTH. VON CIS‐DIHALOGENOTETRAPYRIDIN‐RUTHENIUM(II)‐KOMPLEXEN UND BESTAETIGUNG IHRER CIS‐STEREOCHEMIE (1972)

Abstract Die cis‐Titelkomplexe (I) werden in drei Stufen ausgehend von Ru(III)‐chlorid und K‐oxalat durch Behandlung des gebildeten K‐tris‐[oxalato]‐ruthenats(III) mit Pyridin und Zn‐amalgam‐Reduktion und durch Reaktion des erhaltenen cis‐Oxalatotetrapyridin‐Ru(II) mit konz. Halogenwasserstoffsäuren dargestellt.
Basophils and eosinophils in human milk in relation to maternal allergy (1992)

Forty–three specimens of human milk were obtained from allergic and non–allergic women 3–6 days post–partum and analyzed for their eventual content of eosinophils and metachromatically staining cells. Eosinophils and metachromatically staining cells were identified in all milk samples; however, in lower numbers than in peripheral blood (0.082 to 4. 44% and 0.002 to 0.098% resp. of total cell numbers). Possible contamination of milk fluid with peripheral blood was ruled out. As no mast cells were detected with monoclonal anti–tryptase antibodies, the metachromatically staining cells were basophils. The numbers of basophils and eosinophils in milk were positively correlated to each other (p &lt; 0.05) and to blood eosinophil counts (p 0 &lt; 0.001 and p 1 = 0.01, respectively), suggesting migration of these cells from blood to the mammary glands. Significantly higher numbers of eosinophils, but not of basophils were encountered in milk of allergic women compared to milk of non–allergic mothers (p 0 &lt; 0.01 and p 1 &gt; 0.05, respectively). As histamine release in the gut increases gut permeability and thereby probably the risk for sensitization to food allergens, basophils in milk might represent an allergy risk factor for the suckling neonate.
Software Reliability Management (2009)

This entry identifies the factors that control software reliability and the approaches that are needed to achieve desired reliability targets. Common reliability measures are defined. The factors that impact defect density and defect finding rates are discussed and software reliability growth modeling is introduced. Both test-time- and test-coverage-based models are introduced. Modeling for security vulnerability discovery process is also presented. Reliability of multicomponent software systems is discussed followed by optimal allocation of test resources to achieve a target reliability level. Finally some of the applicable software tools available today are mentioned.
Silver behenate powder as a possible low-angle calibration standard for small-angle neutron scattering (1998)

Small-angle neutron scattering (SANS) is a transmission method working in the angular range 0.4–6° (2θ). In this paper, silver behenate powder [CH 3 (CH 2 ) 20 COOAg] (referred to as `AgBE'), one of the very few materials featuring Bragg reflections in the angular range accessible to SANS instruments, is suggested as a possible new SANS wavelength calibration standard. In the past, this powder has been successfully tested as a calibration standard in low-angle X-ray diffraction. Results of new SANS wavelength calibration measurements performed with AgBE and with the traditional method of time-of-flight measurements are presented and compared with low-angle X-ray diffraction measurements.
ChemInform Abstract: A BIOGENETICALLY SIGNIFICANT CYCLIZATION OF HUMULENE‐4,5‐EPOXIDE. THE SYNTHESIS OF THE AFRICANE‐TYPE SESQUITERPENOID, 1,5,8,8‐TETRAMETHYL‐TRICYCLO(8,1,0,0(2,6))UNDEC‐5‐EN‐9‐OL‐4‐ONE (1980)

Abstract Untersuchungen an Humulen (I) und seinem 4,5‐Epoxid (II) werden im Zusammenhang mit der Synthese von Naturstoffen beschrieben.