gebhart/patrepeval huggingface dataset:
Towards Robust Monocular Depth Estimation: Mixing Datasets for Zero-shot Cross-dataset Transfer (2019)

The success of monocular depth estimation relies on large and diverse training sets. Due to the challenges associated with acquiring dense ground-truth depth across different environments at scale, a number of datasets with distinct characteristics and biases have emerged. We develop tools that enable mixing multiple datasets during training, even if their annotations are incompatible. In particular, we propose a robust training objective that is invariant to changes in depth range and scale, advocate the use of principled multi-objective learning to combine data from different sources, and highlight the importance of pretraining encoders on auxiliary tasks. Armed with these tools, we experiment with five diverse training datasets, including a new, massive data source: 3D films. To demonstrate the generalization power of our approach we use zero-shot cross-dataset transfer}, i.e. we evaluate on datasets that were not seen during training. The experiments confirm that mixing data from complementary sources greatly improves monocular depth estimation. Our approach clearly outperforms competing methods across diverse datasets, setting a new state of the art for monocular depth estimation. Some results are shown in the supplementary video at https://youtu.be/D46FzVyL9I8
Ganymede: An Extensible and Customizable Directory Management Framework (1998)

In the fall of 1994, Applied Research Laboratories, The University of Texas at Austin (ARL:UT) presented a paper [1] at LISA VIII, describing work that we had performed designing and implementing a management framework for NIS and DNS, called GASH. In the years since that paper was presented, it has become clear that the design of GASH was insufficient to meet the complex, idiosyncratic, and rapidly changing needs of modern networking. GASH suffered from being too inflexible to be rapidly retooled for a changing network environment, from being limited to a single user at a time, and from being unable to provide management services to custom clients. In the face of these issues, the Computer Science Division at ARL:UT went back to the drawing board and developed a Java-based directory management framework on the basis of the design principles presented in our GASH paper. Written in Java, Ganymede 1 is based on a distributed object design using the Java Remote Method Invocat...
Shelmo (1886)

Shelmo Get access D. A. D. A. Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s7-II, Issue 28, 10 July 1886, Page 28, https://doi.org/10.1093/nq/s7-II.28.28g Published: 10 July 1886
Enhancement of Antimicrobial Activity of Chitosan by Irradiation (1997)

Antimicrobial activity of irradiated chitosan was studied against Escherichia coli B/r. Irradiation of chitosan at 100 kGy under dry conditions was effective in increasing the activity, and inhibited the growth of E coli completely. The molecular weight of chitosan significantly decreased with the increase in irradiation dose, whereas the relative surface charge of chitosan was decreased only 3% by 100 kGy irradiation. Antimicrobial activity assay of chitosan fractionated according to molecular weight showed that 1×105–3×105 fraction was most effective in suppressing the growth of E coli. This fraction comprised only 8% of the 100 kGy irradiated chitosan. On the other hand, chitosan whose molecular weight was less than 1×105 had no activity. The results show that low dose irradiation, specifically 100 kGy, of chitosan gives enough degradation to increase its antimicrobial activity as a result of a change in molecular weight. © 1997 SCI.
Synthesis and C.d. spectra of 6,6a,7,11b-tetrahydro-5H-indeno[2,1-c]-isoquinoline derivatives (1984)

We have synthesized the title compounds having two pharmacophores of the β-phenethylamine moiety with a semi-rigid spatial arrangement. They are very suitable for studies on the limit of the effect of electron exchange between two aromatic chromophores. X-Ray crystallography was carried out to determine the molecular structure of the skeleton compounds: 6,6a,7,11b-tetrahydro-5H-indeno[2,1-c]isoquinoline and 5,6,6a,7,8,12a-hexahydrobenz[a]phenanthridine. For compounds which showed positive Cotton effects, independent of the substituent pattern of the methoxy groups, in the region of the 1Lb benzenoid transition and the longer wavelength part of the 1B benzenoid transition, absolute configurations were determined by chemical correlation to (1R,2R)-(–)-2-aminoindan-1-ol and (1R,2R)-(–)-2-amino-5-methoxyindan-1-ol. The absolute configuration of the last-named was determined by X-ray crystrallography. An empirical rule was applied to determine the absolute configuration of the other compounds and was supported by, theoretical calculations.
Identification of efonidipine hydrochloride metabolites in rats. (1995)

The metabolism of efonidipine hydrochloride (CAS 111011-76-8, NZ-105), a new dihydropyridine calcium antagonist, was studied after oral or intraperitoneal dosing in rats. Six metabolites were isolated from urine and bile and their structures were confirmed by spectral and chromatographic comparison with the authentic compounds. The main metabolic pathway of efonidipine hydrochloride involved N-debenzylation, N-dephenylation, oxidative deamination, ester hydrolysis and oxidation of the 1,4-dihydropyridine ring to the corresponding pyridine.
Neuropsychological Profiles of Children Following Vitamin B12 Deficiency During Infancy: A Case Series (2016)

Previous studies investigating long-term outcomes in children following vitamin B12 deficiency during infancy have been limited to IQ or clinical observation. This paper seeks to describe comprehensive neuropsychological profiles in a case series of school-aged children who were treated for infantile vitamin B12 deficiency. This was a retrospective case series of seven children who were treated for vitamin B12 deficiency during infancy and aged 5 to 16 years at the time of testing. While most children had age-expected intellectual performance, the distribution of the sample was skewed to the lower end of the normal range. Furthermore, children were found to have impairments in a number of neuropsychological domains, most common were attention and memory, followed by executive function. These results suggest that while neurological symptoms quickly resolve following treatment, these effects on early brain development may disrupt brain maturation and have the potential to impact on later development.
Research (1999)

A significant proportion of healthcare expenditure is directed towards neonatal intensive care. Infants who receive intensive care include those born with generic anomalies, and yet these infants are a unique group in that the care they receive does not alter the overall prognosis of their disorder.
Natriuretic peptides enhance the oxidative capacity of human skeletal muscle (2012)

Cardiac natriuretic peptides (NP) are major activators of human fat cell lipolysis and have recently been shown to control brown fat thermogenesis. Here, we investigated the physiological role of NP on the oxidative metabolism of human skeletal muscle. NP receptor type A (NPRA) gene expression was positively correlated to mRNA levels of PPARγ coactivator-1α (PGC1A) and several oxidative phosphorylation (OXPHOS) genes in human skeletal muscle. Further, the expression of NPRA, PGC1A, and OXPHOS genes was coordinately upregulated in response to aerobic exercise training in human skeletal muscle. In human myotubes, NP induced PGC-1α and mitochondrial OXPHOS gene expression in a cyclic GMP-dependent manner. NP treatment increased OXPHOS protein expression, fat oxidation, and maximal respiration independent of substantial changes in mitochondrial proliferation and mass. Treatment of myotubes with NP recapitulated the effect of exercise training on muscle fat oxidative capacity in vivo. Collectively, these data show that activation of NP signaling in human skeletal muscle enhances mitochondrial oxidative metabolism and fat oxidation. We propose that NP could contribute to exercise training-induced improvement in skeletal muscle fat oxidative capacity in humans.
Signal transduction pathways and apoptosis in bacteria infected chondrocytes (2001)

The mechanism underlying chronic destructive arthropathy after pyogenic arthritis is not clear. This study evaluated the role of apoptosis in Staphylococcus aureus infected human articular chondrocytes and investigated the signal transduction pathways activated by bacterial infection. Chondrocytes cultured in monolayer were challenged with bacteria for 6 h and were analyzed after incubation for 2, 18, and 24 h. Chondrocytes showed morphologic and biochemical evidences of apoptosis after infection and the following incubation period. Although treatment with extensive washing and vancomycin could ameliorate the amount of apoptosis from 31% to 15% at 2 h, from 48% to 23% at 18 h, and from 58% to 33% at 24 h, the infected samples with treatment still had higher amount of apoptosis than the un-infected controls (ANOVA P < 0.001). Accompanying with the increasing amount of apoptosis, the caspase activity was upregulated in bacteria infected samples and remained high in samples with treatment (ANOVA P < 0.05). Signal transduction pathways activated by bacterial infection were assessed by co-transfection technique. After infection, the c-Jun N-terminal kinase, extracellular signal-regulated kinase, and cyclic AMP-dependent protein kinase activities were elevated by 7.6-, 7.3-, and 3.2-fold, respectively, compared to the uninfected controls. The data support the hypothesis that human chondrocytes will undergo apoptosis after infection by a single organism. Apoptosis and activated intracellular kinase activities may be related to the pathogenesis of post-infectious destructive arthropathy.
Purinergic signaling microenvironments: An introduction (2008)

The common theme of this introductory article and the minireviews that follow in this special issue is the concept of microenvironments within tissues and surrounding cells that would be ideal signaling venues for a biologically active purinergic ligand. Collectively, the editors/authors and the other contributing authors agree that nucleotides and nucleosides would be most potent within a confined system. A talented cadre of purinergics has been solicited to discuss purinergic signaling in his or her favorite microenvironment within a given organ or tissue. We are gratified by the large number of original articles that also have successfully navigated the peer review process and are part of this special issue. These concepts are not simply purinergic, but the idea of maximal potency in a tissue microenvironment and surrounding specialized cells within a tissue pertains to any autacoid or paracrine agonist.
Bone Reconstruction following Application of Bone Matrix Gelatin to Alveolar Defects: A Randomized Clinical Trial. (2015)

The data from this single-blind clinical trial demonstrated that the novel combination of BMG had a striking effect on de novo osseous formation for the bone regeneration.
Acid Initiation of Ammonia–Borane Dehydrogenation for Hydrogen Storage (2006)

Liberating hydrogen: Strong Lewis or Brønsted acids react with ammonia–borane (H3NBH3) to form an in situ boronium cation, resulting in the formation of a mixture of cyclic and acyclic BNHx oligomers and the liberation of H2 (see scheme). A proposed mechanism is supported by an examination of the reaction thermodynamics using density functional theory.
A Study on the Effect of Preview Uncertainties in Preview Control of Vehicle Suspensions (2001)

Abstract The benefit of previewing the “future” road inputs in improving the performance of active suspensions of a vehicle has been demonstrated in many publications. It is shown that smoother and more effective control is possible when the preview length is increased up to a certain limit. Most of these studies assume perfect preview measurements in their numerical simulations. In a real scenario however, the presence of uncertainties can not be neglected. The uncertainties can be due to sensor measurement noise or false objects on the surface of the road. In order to gain an insight to the problem this paper addresses the influence of preview uncertainty on the performance of a preview controller. The stochastic optimal control scheme for preview control of a quarter-car suspension model is briefly presented. Then results of numerical simulations, which are carried out for various levels of uncertainty in the preview and for different preview lengths, are compared. These comparisons show that noise/uncertainty can be an issue with an adverse effect that sometimes increases with preview length. In other words, it is shown that controllers with longer preview can be more susceptible to noise. However the limits of tolerable noise are not very restrictive and the well-known benefits of preview can still be achieved if the measurement errors are maintained below a limited level.
Composition-dependent photoluminescence intensity and prolonged recombination lifetime of perovskite CH3NH3PbBr3−xClxfilms (2014)

Mixed halide perovskites CH3NH3PbBr3-xClx (x = 0.6-1.2) with different compositions of halogens exhibit drastically changed optical properties. In particular, the thin films prepared with these perovskites demonstrate extraordinary photoluminescence emission intensities and prolonged recombination lifetimes up to 446 ns, which are desirable for light emitting and photovoltaic applications.
Development of a Simulation Tool of a Two-Axis Nano Stage for a New Generation Lithography System (2004)

A nano-stage simulation tool is developed for an advanced E-beam lithography system. Even if piezoare-actuators believed to be compatible for the E-beam lithograpy system, it is difficult to predict their characteristics due to their nonlinearities such as hysteresis and creep. In this paper, the nonlinear properties are modeled for a piezo-actuator by considering the voltage range and speed variations. The hysteresis is described as the first order differential equation with 24 sets of parameters and the creep is modeled as a timelogarithmic function with 2 sets of a parameter. A two-axis nano stage with piezo-actuators are investigated for realizing nano scale motions. The characteristics of flexure guide mechanisms are analyzed based on the finite element method using the ANSYS software. The simulation tool for the nano stage is constincted by using the RecurDyn software. The dynamic response of the nano stage is obtained in simulations and compared with the experimental data.
Characterizing reference locality in the WWW (2002)

The authors propose models for both temporal and spatial locality of reference in streams of requests arriving at Web servers. They show that simple models based on document popularity alone are insufficient for capturing either temporal or spatial locality. Instead, they rely on an equivalent, but numerical, representation of a reference stream: a stack distance trace. They show that temporal locality can be characterized by the marginal distribution of the stack distance trace, and propose models for typical distributions and compare their cache performance to the traces. They also show that spatial locality in a reference stream can be characterized using the notion of self-similarity. Self-similarity describes long-range correlations in the data set, which is a property that previous researchers have found hard to incorporate into synthetic reference strings. They show that stack distance strings appear to be strongly self-similar, and provide measurements of the degree of self-similarity in the traces. Finally, they discuss methods for generating synthetic Web traces that exhibit the properties of temporal and spatial locality measured in the data.
Biliary epithelial cells and primary biliary cirrhosis: The role of liver-infiltrating mononuclear cells (2008)

We submit that the proinflammatory activity of BECs in PBC is secondary to the intervention of LMNCs and is not determined per se. These data support the hypothesis that BECs are in fact "innocent victims" of autoimmune injury and that the adaptive immune response is critical in PBC.
Plasmon hybridization in spherical nanoparticles (2004)

We show that the plasmon resonances in single metallic nanoshells and multiple concentric metallic shell particles can be understood in terms of interaction between the bare plasmon modes of the individual surfaces of the metallic shells. The interaction of these elementary plasmons results in hybridized plasmons whose energy can be tuned over a wide range of optical and infrared wavelengths. The approach can easily be generalized to more complex systems, such as dimers and small nanoparticle aggregates.
Popular Education, ‘So We Stand’ and the ‘Triple Self-Diagnosis’ (2013)

With funding from the Economic and Social Research Council, a novel project has taken place over the last two years under the title ‘Using Popular Education in Anti-Poverty and Environmental Justice Organising: Bridging Constituencies, Building Movements, and Crossing Disciplines’. The aim was not just to take a popular education approach to promoting social change but also to make learning about popular education a central part of the process.
Many Medicare Beneficiaries Do Not Fill High-Price Specialty Drug Prescriptions (2022)

For high-price drugs, Medicare Part D beneficiaries who do not receive a low-income subsidy must pay a percentage of the drug's price for each medication fill. Without that subsidy, which lowers out-of-pocket spending, beneficiaries typically pay hundreds or thousands of dollars for a single fill. We estimated the proportion of Part D beneficiaries in fee-for-service Medicare, with and without a subsidy, who do not initiate treatment (that is, do not fill a new prescription) with high-price Part D drugs newly prescribed for four conditions. Examining 17,076 new prescriptions issued between 2012 and 2018 for Part D beneficiaries from eleven geographically diverse health systems, we found that beneficiaries receiving subsidies were nearly twice as likely to obtain the prescribed drug within ninety days as those without subsidies. Among beneficiaries without subsidies, we observed noninitiation for 30 percent of prescriptions written for anticancer drugs, 22 percent for hepatitis C treatments, and more than 50 percent for disease-modifying therapies for either immune system disorders or hypercholesterolemia. Our findings support current legislative efforts to increase the accessibility of high-price medications by reducing out-of-pocket expenses under Medicare Part D, particularly for beneficiaries without low-income subsidies.
Three-Dimensional Wind Measurement Based on Ultrasonic Sensor Array and Multiple Signal Classification (2020)

The wind power industry continues to experience rapid growth worldwide. However, the fluctuations in wind speed and direction complicate the wind turbine control process and hinder the integration of wind power into the electrical grid. To maximize wind utilization, we propose to precisely measure the wind in a three-dimensional (3D) space, thus facilitating the process of wind turbine control. Natural wind is regarded as a 3D vector, whose direction and magnitude correspond to the wind's direction and speed. A semi-conical ultrasonic sensor array is proposed to simultaneously measure the wind speed and direction in a 3D space. As the ultrasonic signal transmitted between the sensors is influenced by the wind and environment noise, a Multiple Signal Classification algorithm is adopted to estimate the wind information from the received signal. The estimate's accuracy is evaluated in terms of root mean square error and mean absolute error. The robustness of the proposed method is evaluated by the type A evaluation of standard uncertainty under a varying signal-to-noise ratio. Simulation results validate the accuracy and anti-noise performance of the proposed method, whose estimated wind speed and direction errors converge to zero when the SNR is over 15 dB.
Abstract LB-293: Perfluorocarbon labeling of human α-type-1-polarized dendritic cells and conventional dendritic cells for in vivo trafficking by fluorine MRI (2011)

Abstract Human dendritic cells (DC) have yet to live up to their clinical promise as an immunotherapeutic intervention against cancer, in spite of their in vitro profiles of their ability to effectively prime tumor-specific T cell responses. It is still unclear which is the best route of administration for the most efficient interaction of DC with tumor-specific T cells in patients, and whether the migratory capacity and localization of DC in patients correlates with clinical responsiveness. Here we utilize a perfluorocarbon (PFC) magnetic resonance imaging (MRI) tracer agent which may enable the assessment of the migration and localization of α-type-1-polarized dendritic cells (αDC1) in the clinic. αDC1 producing high levels of interleukin-12p70 with putative strong lymph node homing capabilities, are currently being evaluated clinically for anti-cancer activity. In vivo results demonstrate the capability of 19F MRI to detect and quantify labeled cells with moderate sensitivity, detecting fewer than 1×104 cells per voxel. The lack of endogenous fluorine in the body allows highly-specific 19F MR detection of label and when paired with proton MRI provides clear and quantitative cell localization within their anatomical context. The inertness of this tracking agent on the functional capacity of DC was examined in a panel of in vitro studies. The use of the MRI tracer with both conventional DC and αDC1 indicated similar labeling efficiencies with no observed effect on the DC's ability to stimulate T cell expansion, produce IL-12p70, process antigen or express co-stimulatory and polarizing factors. These data support the clinical translation of this tracer agent to safely track and quantify the administration and migration of human αDC1 by non-invasive 19F MRI in the treatment of cancer patients. An imminent clinical trial of PFC-labeled αDC1 will provide cell tracking data in patients, facilitating advances in greater efficacy in the next generation of DC-based cellular vaccines. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr LB-293. doi:10.1158/1538-7445.AM2011-LB-293
The emerging physical health challenges of antipsychotic associated hyperprolactinaemia in patients with serious mental illness (2008)

Serdar M Dursun Neuroscience and Psychiatry Unit, University of Manchester, Manchester, UK. Hiram Joseph Wildgust PhD, Hiram Consulting, Ackworth, West Yorkshire, UK. Paul Strickland Consultant Psychiatrist, BSTMHT & University of Manchester, Manchester, UK. Guy M Goodwin Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK. Leslie Citrome Department of Psychiatry, New York University School of Medicine and the Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA. Mike Lean Department of Human Nutrition, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK.