gebhart/patrepeval huggingface dataset:
Endoscopy Today (1972)

Some of the technics of flexible fiber endoscopy are still in early stages of development, but the new instruments hold promise of diagnostic importance. An esophagogastroscope 1,050 mm in length makes possible visualization of the esophagus, stomach, and duodenal bulb. Duodenoscopy with cannulation of the papilla of Vater is a new technic of retrograde cholangiography or pancreatography. New colonoscopes are long enough for endoscopic examination of the entire colon.
Figure S2 from p21CIP1 Promotes Mammary Cancer–Initiating Cells via Activation of Wnt/TCF1/CyclinD1 Signaling (2023)

&lt;p&gt;Figure S2. LEF1 knockdown in PyMT cells does not inhibit Wnt signaling or mammosphere formation.&lt;/p&gt;
Minimal invasive LVAD implantation via bilateral thoracotomy (2013)

Objective: A median sternotomy is the standard incision for left ventricular assist device (LVAD) implantation. There are some theoretical advantages of avoiding a median sternotomy in LVAD patients including better right ventricular protection, improved pulmonary function and faster recovery. The present study was designed to evaluate a novel, minimally invasive sternotomy sparing technique for LVAD implantation.
Introduction (1986)

As the prices of microprocessor chips have fallen, they have increasingly become standard, ‘off the shelf’ components and find their way into a very large proportion of modern electronic equipment and instrumentation. A microprocessor built into a piece of equipment, rather than providing the central processor for a general-purpose microcomputer, is said to be ‘dedicated’ or ‘embedded’. The software which controls such a device is necessarily specialised and is usually called ‘firmware’. This term will be used throughout this book. Strictly speaking, firmware is code which has been placed in non-volatile, read-only memory (ROM) chips, which are built into the circuit with the microprocessor, but this is not always the case, as alternative memory schemes are possible. The various techniques associated with the development of firmware are the subject of this book.
Photocatalyzed Sulfide Oxygenation with Water as the Unique Oxygen Atom Source (2012)

In our research program aiming to develop new ruthenium-based polypyridine catalysts for oxidation we were interested in combining a photosensitizer and a catalytic fragment within the same complex to achieve catalytic light-driven oxidation. To respond to the lack of such conjugates, we report here a new catalytic system capable of using light to activate water molecules in order to perform selective sulfide oxygenation into sulfoxide via an oxygen atom transfer from H(2)O to the substrate with a TON of up to 197 ± 6. On the basis of electrochemical and photophysical studies, a proton-coupled electron-transfer process yielding to an oxidant Ru(IV)-oxo species was proposed. In particular, the synergistic effect between both partners in the dyad yielding a more efficient catalyst compared to the bimolecular system is highlighted.
Thermal Characterization of Vanadium Dioxide and its Moldings around the Phase Transition Temperature (2021)

本研究では粉末状の二酸化バナジウムから成型された構造材の熱挙動の把握を目的として，焼結成型体およびバインダー成型体を実際に作製し，加温実験および熱回路網法を用いたシミュレーションによる熱特性の検討を行った．その結果，二酸化バナジウムの相転移温度において潜熱の影響により温度維持の効果がある事，熱回路網法による温度変化の予測が可能であるという結果が得られた．さらに，バインダーの種類を変えた場合には，バインダーの熱物性値により，成型体そのものの熱挙動が大きく変化することがわかった．
Genetic analysis of Verticillium wilt resistance in a backcross inbred line population and a meta-analysis of quantitative trait loci for disease resistance in cotton (2015)

Ten VW resistance QTL identified in a 4-year replicated study have added useful information to the understanding of the genetic basis of VW resistance in cotton. Twenty-eight disease resistance QTL clusters and 24 hotspots identified from a total of 306 QTLs and linked SSR markers provide important information for marker-assisted selection and high resolution mapping of resistance QTLs and genes. The non-overlapping of most resistance QTL hotspots for different diseases indicates that their resistances are controlled by different genes.
Prion protein glycans reduce intracerebral fibril formation and spongiosis in prion disease (2020)

Posttranslational modifications (PTMs) are common among proteins that aggregate in neurodegenerative disease, yet how PTMs impact the aggregate conformation and disease progression remains unclear. By engineering knockin mice expressing prion protein (PrP) lacking 2 N-linked glycans (Prnp180Q/196Q), we provide evidence that glycans reduce spongiform degeneration and hinder plaque formation in prion disease. Prnp180Q/196Q mice challenged with 2 subfibrillar, non-plaque-forming prion strains instead developed plaques highly enriched in ADAM10-cleaved PrP and heparan sulfate (HS). Intriguingly, a third strain composed of intact, glycophosphatidylinositol-anchored (GPI-anchored) PrP was relatively unchanged, forming diffuse, HS-deficient deposits in both the Prnp180Q/196Q and WT mice, underscoring the pivotal role of the GPI-anchor in driving the aggregate conformation and disease phenotype. Finally, knockin mice expressing triglycosylated PrP (Prnp187N) challenged with a plaque-forming prion strain showed a phenotype reversal, with a striking disease acceleration and switch from plaques to predominantly diffuse, subfibrillar deposits. Our findings suggest that the dominance of subfibrillar aggregates in prion disease is due to the replication of GPI-anchored prions, with fibrillar plaques forming from poorly glycosylated, GPI-anchorless prions that interact with extracellular HS. These studies provide insight into how PTMs impact PrP interactions with polyanionic cofactors, and highlight PTMs as a major force driving the prion disease phenotype.
The Design, Build and Test of a Digital Analyzer for Mixed Radiation Fields (2010)

The design, build and test of a digital analyzer for mixed radiation fields is described. This instrument has been developed to provide portable, real-time discrimination of hard mixed fields comprising both neutrons and γ rays with energies typically above 0.5 MeV. The instrument in its standard form comprises a sensor head and a system unit, and affords the flexibility to provide processed data in the form of the traditional scatter-plot representation separating neutron and γ -ray components, or the full, sampled pulse data itself. The instrument has been tested with an americium-beryllium source in three different shielding arrangements to replicate the case in which there are only neutrons, only γ rays and where both neutrons and γ -rays are present. The instrument is observed to return consistent results.
A Bird’s Eye View of Human Language Evolution (2012)

COMPARATIVE STUDIES OF LINGUISTIC FACULTIES IN ANIMALS POSE AN EVOLUTIONARY PARADOX: language involves certain perceptual and motor abilities, but it is not clear that this serves as more than an input-output channel for the externalization of language proper. Strikingly, the capability for auditory-vocal learning is not shared with our closest relatives, the apes, but is present in such remotely related groups as songbirds and marine mammals. There is increasing evidence for behavioral, neural, and genetic similarities between speech acquisition and birdsong learning. At the same time, researchers have applied formal linguistic analysis to the vocalizations of both primates and songbirds. What have all these studies taught us about the evolution of language? Is the comparative study of an apparently species-specific trait like language feasible? We argue that comparative analysis remains an important method for the evolutionary reconstruction and causal analysis of the mechanisms underlying language. On the one hand, common descent has been important in the evolution of the brain, such that avian and mammalian brains may be largely homologous, particularly in the case of brain regions involved in auditory perception, vocalization, and auditory memory. On the other hand, there has been convergent evolution of the capacity for auditory-vocal learning, and possibly for structuring of external vocalizations, such that apes lack the abilities that are shared between songbirds and humans. However, significant limitations to this comparative analysis remain. While all birdsong may be classified in terms of a particularly simple kind of concatenation system, the regular languages, there is no compelling evidence to date that birdsong matches the characteristic syntactic complexity of human language, arising from the composition of smaller forms like words and phrases into larger ones.
Veterinary ophthalmology essentials (2004)

1 Signalment, History, and Physical Examination 2 Eyelids 3 Lacrimal Glands, Conjunctival Goblet Cells, Tarsal Glands, and Tear Film Anatomy, Embryology, and Physiology 4 Anatomy, Physiology, and Embryology of the Nasolacrimal System 5 Anatomy, Embryology, Physiology, and Clinical Manifestations of Orbital Disease 6 Embryology, Anatomy, Physiology, and Pathophysiology of the Cornea 7 Embryology, Anatomy, and Physiology of the Sclera 8 Embryology, Anatomy, and Physiology of the Uvea 9 Embryology, Anatomy, and Physiology of the Lens 10 Anatomy, Physiology, and Pathophysiology of Aqueous Humor Production and Exit 11 Embryology, Anatomy, Physiology, and Pathophysiology of the Vitreous 12 Embryology, Anatomy, and Physiology of the Retina 13 Embryology, Anatomy, Physiology, and Pathophysiology of the Optic Nerve 14 Neuro-Ophthalmology 15 Orbit 16 Ocular Anatomy and Physiology of the Horse 17 Ophthalmic Examination of Food Animals 18 Exotic Mammalian Pets: Mice, Rats, Gerbils, Hamsters, Guinea Pigs, Ferrets, Rabbits and Others 19 Injury and Healing 20 Ocular Pharmacokinetic Considerations 21 Basic Ocular Surgery: Indications, Contraindications and Procedures
A Software Architecture for Automatic Deployment of CORBA Components Using Grid Technologies (2004)

Software components turn out to be a convenient model to build complex applications for scientific computing and to run them on a computational grid. However, deploying complex, component-based applications in a grid environment is particularly arduous. To prevent the user from directly dealing with a large number of execution hosts and their heterogeneity within a grid, the application deployment phase must be as automatic as possible. This paper describes an architecture for automatic deployment of component-based applications on computational grids. In the context of the CORBA Component Model (CCM), this paper details all the steps to achieve an automatic deployment of components as well as the entities involved: a grid access middleware and its grid information service (like OGSI), a component deployment model, as specified by CCM, an enriched application description and a deployment planner in order to select resources and map components onto computers.
HGF/SF c‐Met Signaling in the Epithelial–Mesenchymal Transition and Migration of Muscle Progenitor Cells (2004)

This chapter contains sections titled: Introduction: Hepatocyte Growth Factor/scatter Factor (HGF/SF) is a Pleiotropic Growth Factor HGF/SF is the Ligand for the Proto-oncogene c-Met HGF/SF acts as a Paracrine Growth Factor in Normal Tissue Functional Role of HGF/SF and c-Met in the Development of Skeletal Muscles c-Met Substrates are Required for Migration of Muscle Progenitor Cells Evolution of Migratory Muscle Progenitor Cells Outlook Acknowledgments References
Angiotensin II analogs. III. Synthesis and biological evaluation of some des-aspartyl-angiotensins (1970)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAngiotensin II analogs. III. Synthesis and biological evaluation of some des-aspartyl-angiotensinsEugene C. Jorgensen, Graham C. Windridge, and Thomas Choy LeeCite this: J. Med. Chem. 1970, 13, 3, 352–356Publication Date (Print):May 1, 1970Publication History Published online1 May 2002Published inissue 1 May 1970https://pubs.acs.org/doi/10.1021/jm00297a004https://doi.org/10.1021/jm00297a004research-articleACS PublicationsRequest reuse permissionsArticle Views303Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Difficulty in identification of the frontal language area in patients with dominant frontal gliomas that involve the pars triangularis (2016)

OBJECTIVE Identification of language areas using functional brain mapping is sometimes impossible using current methods but essential to preserve language function in patients with gliomas located within or near the frontal language area (FLA). However, the factors that influence the failure to detect language areas have not been elucidated. The present study evaluated the difficulty in identifying the FLA in dominant-side frontal gliomas that involve the pars triangularis (PT) to determine the factors that influenced failed positive language mapping. METHODS Awake craniotomy was performed on 301 patients from April 2000 to October 2013 at Tokyo Women's Medical University. Recurrent cases were excluded, and patients were also excluded if motor mapping indicated their glioma was in or around the motor area on the dominant or nondominant side. Eighty-two consecutive cases of primary frontal glioma on the dominant side were analyzed for the present study. MRI was used for all patients to evaluate whether tumors involved the PT and to perform language functional mapping with a bipolar electrical stimulator. Eighteen of 82 patients (mean age 39 ± 13 years) had tumors that showed involvement of the PT, and the detailed characteristics of these 18 patients were examined. RESULTS The FLA could not be identified with intraoperative brain mapping in 14 (17%) of 82 patients; 11 (79%) of these 14 patients had a tumor involving the PT. The negative response rate in language mapping was only 5% in patients without involvement of the PT, whereas this rate was 61% in patients with involvement of the PT. Univariate analyses showed no significant correlation between identification of the FLA and sex, age, histology, or WHO grade. However, failure to identify the FLA was significantly correlated with involvement of the PT (p < 0.0001). Similarly, multivariate analyses with the logistic regression model showed that only involvement of the PT was significantly correlated with failure to identify the FLA (p < 0.0001). In 18 patients whose tumors involved the PT, only 1 patient had mild preoperative dysphasia. One week after surgery, language function worsened in 4 (22%) of 18 patients. Six months after surgery, 1 (5.6%) of 18 patients had a persistent mild speech deficit. The mean extent of resection was 90% ± 7.1%. Conclusions Identification of the FLA can be difficult in patients with frontal gliomas on the dominant side that involve the PT, but the positive mapping rate of the FLA was 95% in patients without involvement of the PT. These findings are useful for establishing a positive mapping strategy for patients undergoing awake craniotomy for the treatment of frontal gliomas on the dominant side. Thoroughly positive language mapping with subcortical electrical stimulation should be performed in patients without involvement of the PT. More careful continuous neurological monitoring combined with subcortical electrical stimulation is needed when removing dominant-side frontal gliomas that involve the PT.
Building a Networked Improvement Community: Lessons in Organizing to Promote Diversity, Equity, and Inclusion in Science, Technology, Engineering, and Mathematics (2021)

In 2016, 10 universities launched a Networked Improvement Community (NIC) aimed at increasing the number of scholars from Alliances for Graduate Education and the Professoriate (AGEP) populations entering science, technology, engineering, and mathematics (STEM) faculty careers. NICs bring together stakeholders focused on a common goal to accelerate innovation through structured, ongoing intervention development, implementation, and refinement. We theorized a NIC organizational structure would aid understandings of a complex problem in different contexts and accelerate opportunities to develop and improve interventions to address the problem. A distinctive feature of this NIC is its diverse institutional composition of public and private, predominantly white institutions, a historically Black university, a Hispanic-serving institution, and land grant institutions located across eight states and Washington, DC, United States. NIC members hold different positions within their institutions and have access to varied levers of change. Among the many lessons learned through this community case study, analyzing and addressing failed strategies is as equally important to a healthy NIC as is sharing learning from successful interventions. We initially relied on pre-existing relationships and assumptions about how we would work together, rather than making explicit how the NIC would develop, establish norms, understand common processes, and manage changing relationships. We had varied understandings of the depth of campus differences, sometimes resulting in frustrations about the disparate progress on goals. NIC structures require significant engagement with the group, often more intensive than traditional multi-institution organizational structures. They require time to develop and ongoing maintenance in order to advance the work. We continue to reevaluate our model for leadership, climate, diversity, conflict resolution, engagement, decision-making, roles, and data, leading to increased investment in the success of all NIC institutions. Our NIC has evolved from the traditional NIC model to become the Center for the Integration of Research, Teaching and Learning (CIRTL) AGEP NIC model with five key characteristics: (1) A well-specified aim, (2) An understanding of systems, including a variety of contexts and different organizations, (3) A culture and practice of shared leadership and inclusivity, (4) The use of data reflecting different institutional contexts, and (5) The ability to accelerate infrastructure and interventions. We conclude with recommendations for those considering developing a NIC to promote diversity, equity, and inclusion efforts.
Gibberellins modulate light signaling pathways to prevent Arabidopsis seedling de‐etiolation in darkness (2007)

In many plants, photomorphogenesis is the default developmental program after seed germination, and provides the key features that allow adaptation to light. This program is actively repressed if germination occurs in the absence of light, through a mechanism dependent on the E3 ubiquitin ligase activity that is encoded in Arabidopsis by COP1 (CONSTITUTIVE PHOTOMORPHOGENIC 1), which induces proteolytic degradation of transcription factors necessary for light-regulated development, such as HY5 (LONG HYPOCOTYL 5) and HYH (LONG HYPOCOTYL 5 HOMOLOG), and stabilization of transcription factors that promote skotomorphogenesis, such as PIF3 (PHYTOCHROME INTERACTING FACTOR 3). Seedlings deficient in gibberellin (GA) synthesis or signaling display a de-etiolated phenotype when grown in darkness, equivalent to the phenotype of cop1 mutants, which indicates that the switch between photo- and skotomorphogenesis is also under hormonal control. Here we provide evidence for the existence of crosstalk between GA and the COP1-mediated pathway, and identify HY5 and the PIF family as nodes of a regulatory network. This interaction occurs through distinct molecular mechanisms, based on the observation that GA signaling regulates protein stability of HY5, and the activity of PIF3.
A novel fault location and recognition method for low voltage active distribution network (2015)

As more and more DGs plugged into low voltage side of the distribution network, the low voltage distribution network has been changed to active distribution network. Bidirectional power flow and uncertainty of DGs' output cause the conventional fault location methods to be inapplicable in active distribution network for malfunction and miss trip, which makes the fault location in low voltage active distribution network an urgent problem. In order to solve this problem, a novel fault location and recognition method for low voltage active distribution network which needs 3-phase currents measurement only is proposed in this paper. In the proposed method, a low voltage active distribution network is installed with the measurement and data process units for current measurement and data process at nodes and a control center for fault location and recognition. By the division of the low voltage active distribution network into several two-terminal sections without branch, the fault location (inside/outside the section) with fault-phase selection can be determined by the calculation of A, B and C phase current phase-angle differences of each section and the fault type can be identified by judging the amplitudes of zero-sequence node currents at both ends of every fault section. Simulation verification of the proposed method has been carried out by MATLAB/Simulink, the simulation results indicate that fault in low voltage active distribution network can be located and recognized accurately by the proposed method with fast speed and self-adaption.
Decreased treatment failure in recipients of HLA‐identical bone marrow or peripheral blood stem cell transplants with high CD34 cell doses (2003)

We studied the association between CD34 cell dose and transplant outcomes in 359 bone marrow (BM) and 511 peripheral blood stem cell (PBSC) transplant recipients from human leucocyte antigen (HLA)-identical siblings, reported to the International Bone Marrow Transplant Registry (IBMTR). Transplants for leukaemia were performed between 1995 and 1998. Patients were divided into those receiving below or above the median CD34+ dose, for BM (3 x 106/kg) and PBSC (6 x 106/kg) grafts respectively. Cox proportional hazards regression was used to adjust for baseline patient-, disease- and transplant-related characteristics. Analysis of the BM recipients showed that high CD34 cell dose was associated with lower transplant-related mortality [relative risk (RR) = 0.60, P = 0.033] and treatment failure (inverse of leukaemia-free survival, RR = 0.69, P = 0.032). Among PBSC recipients, high CD34 dose was associated with faster recovery of neutrophils to > 0.5 x 109/l (RR = 1.38, P < 0.001) and platelets to > 20 x 109/l (RR = 1.34, P = 0.003), lower risk of relapse (RR = 0.62, P = 0.029) and treatment failure (RR = 0.74, P = 0.03). We conclude that higher CD34 cell doses decrease treatment failure in recipients of HLA-identical sibling BM and PBSC transplants.