gebhart/patrepeval huggingface dataset:
X-Ray Emission Induced by 60 keV High-Flux Copper Negative-Ion Implantation (2001)

X-ray emission induced by high-flux 60 keV Cu negative ion implantation into silica glasses (a-SiO 2 ) has been studied in the energy range of 0.6–20 keV. At low ion fluxes, the emission spectrum consists of a strong Cu(L) line at 0.95 keV only, without Cu(K) and Si(K) lines. The result is explained by the electron promotion through the quasi-molecule formation. With increasing ion flux, new peaks appear at 1.8, 2.5 and 3.2 keV. These peaks are ascribed to the sum-peak effect under high-flux implantation. Judging from the cross sections and the time dependence, the observed Cu(L) X-ray is concluded to be generated via Cu–O collisions.
Synthesis and Characteristic of Hydrophobic Silica Aerogels (2008)

In this paper,a new method to produce hydrophobic silica aerogels was introduced.SiO2 alcogels were prepared by tetraethoxysilane (TEOS) via Sol-gel precess,then the surface was chemically modified by dimethyldichlorosilane (DMCS),and finally dried by supercritical carbon dioxide method.Test methods,such as FT-IR,SEM,BET and XRD were adopted to analyze the structure,surface morphology,and chemical composition of the samples in the experiments.The results showed that the samples are hydrophobic silica aerogels linked with hydrophobic group (-CH3) on their surface.The hydrophobic silica aerogels were continuous network of spheroidic particles,which the pore diameters mainly ranged from 2 to 10 nm.The samples are non-crystal,porous,light materials with high thermal stability.
Identification and antigenicity of the Babesia caballi spherical body protein 4 (SBP4) (2020)

The Bcsbp4 gene is expressed in B. caballi blood stages. The BcSBP4 protein is a potential candidate for developing a novel serological test that could detect B. caballi infection in equids in tropical and subtropical countries worldwide.
ChemInform Abstract: A SHORT EFFICIENT SYNTHESIS OF 19‐NORANDROST‐4‐ENE‐3,17‐DIONE (1981)

Abstract Die bekannte Diketo‐carbonsäure (I) liefert über das gemischte Anhydrid (II) mit der Grignard‐ Verbindung (III) ein Kondensationsprodukt (IV), das nach Hydrierung zu (V) weiter zum 19‐Nor‐4‐androsten‐3,17‐dion (VI) kondensiert werden kann.
Favorable Outcome for Adolescents With Acute Lymphoblastic Leukemia Treated on Dana-Farber Cancer Institute Acute Lymphoblastic Leukemia Consortium Protocols (2007)

Adolescents were more likely to present at diagnosis with biologically higher risk disease (T-cell phenotype and absence of the TEL-AML1 fusion) and more likely to experience treatment-related complications than younger children. However, the 5-year EFS for older adolescents was 78% +/- 6%, which is superior to published outcomes for similarly aged patients treated with other pediatric and adult ALL regimens. Based on this experience, we currently are piloting our regimen in patients aged 18 to 50 years.
SAT-LB6 First Human Trial of an Oral Native Testosterone Shows Physiological Levels of Testosterone and Dht in Both Fasted and Fed State in Hypogonadal Men (2020)

Abstract Introduction: The prevalence of male hypogonadism is estimated to be 6% in the USA (1). Current therapies have limited acceptability: gels can be messy and risk inadvertent dosing of others; injections are painful; and oral testosterone undecanoate (TU) delivers variable testosterone levels, requires concurrent ingestion of a fatty meal and may produce supraphysiological dihydrotestosterone (DHT) levels. We present the first human trial of an oral native testosterone preparation formulated to deliver physiological levels of testosterone irrespective of food intake. Aim: To compare the pharmacokinetics of DITEST (Diurnal Ltd Cardiff, UK) to an oil based oral TU formulation (Andriol Testocaps MSD, UK) and explore the effect of food on DITEST bioavailability. Methods: Single centre, phase 1b study of DITEST in 25 adult males with hypogonadism, one subject withdrawn after single period and only included in safety analysis (Clinicaltrials.gov: NCT02966652). Part 1 compared the pharmacokinetics of 80mg TU with 120mg DITEST after a high fat meal. Part 2 the pharmacokinetics of 200mg of DITEST administered in either fed or fasted states. Results are baseline adjusted. Results: DITEST showed a testosterone dose response between 120mg and 200mg with Cmax 550 (19.1) and 877 (30.4) ng/dl (nmol/l) and AUC0-10h 59.5 and 88.6 h*nmol/L. DITEST 200mg gave an equivalent Cmax and AUC0-10h to TU 80mg: Cmax 877 (30.4) vs 906 (31.4) ng/dl (nmol/l) and AUC0-10h 88.6 vs 102 h*nmol/L. Fed and fasted DITEST had similar pharmacokinetics: Cmax 764 (26.5) vs 877 (30.4) ng/dl (nmol/L), AUC0-10h 87.0 vs 88.6. DITEST resulted in lower levels of DHT than TU: Cmax 84 (2.9), 131 (4.5) &amp; 194 (6.7) ng/dl (nmol/l); AUC0-10h 11.0, 16.7 &amp; 36.3 h*nmol/L for DITEST 120mg, 200mg &amp; 80mg TU, respectively. There was one serious adverse event (urinary retention) in the study during TU dosing. There were no emerging safety concerns, and adverse event frequency and severity was similar between the two treatments. Discussion: These results demonstrate that 200mg DITEST provides similar testosterone exposure with more physiological DHT exposure than 80mg TU given with a high fat meal. Administration of DITEST in fed and fasted states provides similar testosterone and DHT exposure. Compared to published literature on a self-emulsifying formulation of TU at 200mg, DITEST at 200mg provides a similar testosterone Cmax and no requirement for a fatty meal (2). Conclusion: DITEST is an oral native testosterone formulation with anticipated advantages over current oral therapy of dosing without food and a lower risk of supraphysiological DHT levels. References: 1. Basaria S. Male hypogonadism. Lancet 2014; 383:1250-1263. 2. Yin AY, et al., J Androl 2012; 33:190-201.
Sensitivity of Staphylococcus Aureus, Isolated from Skin Infections in 1994, to 19 Antimicrobial Agents (1995)

The most common pathogen causing skin infections is Staphylococcus aureus and the incidence of multiply resistant strains of S. aureus has been increasing. The in vitro susceptibility of 130 isolates of S. aureus to 19 antimicrobial agents: ampicillin (ABPC), methicillin, cefaclor, cefpodoxime proxetil, gentamicin, erythromycin, clindamycin, minocycline, vancomycin, fusidic acid, norfloxacin, ofloxacin, enoxacin, ciprofloxacin, lomefloxacin, tosufloxacin, sparfloxacin, nadifloxacin and grepafloxacin, was evaluated by agar dilution tests. The S. aureus isolates were isolated from 130 patients with skin infections in 1994. The proportion of methicillin-resistant S. aureus isolates among the strains isolated was 19.2%. The concentration needed to inhibit 50% of the isolates was 3.13 mg/ml or less for all of the drugs, but the concentration needed to inhibit 90% of isolates was over 12.5 micrograms/ml, except in the cases of minocycline, vancomycin, fusidic acid, tosufloxacin and nadifloxacin. Tosufloxacin and nadifloxacin had the lowest minimum inhibitory concentrations. None of the S. aureus strains was resistant to nadifloxacin.
The effect of tether groups on the spin states of iron(ii)/bis[2,6-di(pyrazol-1-yl)pyridine] complexes (2021)

The synthesis of six 2,6-di(pyrazol-1-yl)pyridine derivatives bearing dithiolane or carboxylic acid tether groups is described: [2,6-di(pyrazol-1-yl)pyrid-4-yl]methyl (R)-lipoate (L1), 2-[(2,6-di(pyrazol-1-yl)pyridine)-4-carboxamido]ethyl (R)-lipoate (L2), 2-[(2,6-di(pyrazol-1-yl)pyridine)-4-carboxy]ethyl (R)-lipoate (L3), N-([2,6-di(pyrazol-1-yl)pyrid-4-ylsulfanyl]-2-aminoethyl (R)-lipoamide (L4), 2-[(2,6-di(pyrazol-1-yl)pyridine)-4-carboxamido]acetic acid (L5) and 2-[(2,6-di(pyrazol-1-yl)pyridine)-4-carboxamido]propionic acid (L6). The iron(ii) perchlorate complexes of all the new ligands exhibit gradual thermal spin-crossover (SCO) in the solid state above room temperature, except L4 whose complex remains predominantly high-spin. Crystalline [Fe(L6)2][ClO4]2·2MeCN contains three unique cation sites which alternate within hydrogen-bonded chains, and undergo gradual SCO at different temperatures upon warming. The SCO midpoint temperature (T1/2) of the complexes in CD3CN solution ranges between 208-274 K, depending on the functional group linking the tether groups to the pyridyl ring. This could be useful for predicting how these complexes might behave when deposited on gold or silica surfaces.
Cognitive affordance representations in uncertain logic (2016)

The concept of affordance represents the relationship between human perceivers and their environment. Affordance perception, representation, and inference are central to commonsense reasoning, tool-use and creative problem-solving in artificial agents. Existing approaches fail to provide flexibility with which to reason about affordances in the open world, where they are influenced by changing context, social norms, historical precedence, and uncertainty. We develop a formal rules-based logical representational format coupled with an uncertainty-processing framework to reason about cognitive affordances in a more general manner than shown in the existing literature. Our framework allows agents to make deductive and abductive inferences about functional and social affordances, collectively and dynamically, thereby allowing the agent to adapt to changing conditions. We demonstrate our approach with an example, and show that an agent can successfully reason through situations that involve a tight interplay between various social and functional norms.
XRules (2003)

XML documents have recently become ubiquitous because of their varied applicability in a number of applications. Classification is an important problem in the data mining domain, but current classification methods for XML documents use IR-based methods in which each document is treated as a bag of words. Such techniques ignore a significant amount of information hidden inside the documents. In this paper we discuss the problem of rule based classification of XML data by using frequent discriminatory substructures within XML documents. Such a technique is more capable of finding the classification characteristics of documents. In addition, the technique can also be extended to cost sensitive classification. We show the effectiveness of the method with respect to other classifiers. We note that the methodology discussed in this paper is applicable to any kind of semi-structured data.
Cardiac hormones: morphology and biochemistry. (1986)

The heart contains, in addition to its myocardial working cells and the conductive system, a specialized endocrine part localized mainly in the atrial appendage which is predominantly made up by myoendocrine cells. The ultrastructural and immunocytochemical analysis of myoendocrine cells show a specialized secretory apparatus involved in the synthesis and secretion of cardiac hormones. These cardiac hormones are synthesized and processed in the myoendocrine cells as follows: a preprohormone is found in the rough endoplasmic reticulum, the prohormone cardiodilatin/gamma-atrial natriuretic polypeptide (CDD/ANP) is processed in the Golgi apparatus and stored in the secretory granules. The circulating peptide, cardiodilatin 99-126/alpha-ANP, is the C-terminus of this preprohormone which is released as the active circulating form into the blood stream.
Coupling Vascular and Myocardial Inflammatory Injury into a Common Phenotype of Cardiovascular Dysfunction: Systemic Inflammation and Aging – A Mini-Review (2010)

The rising epidemic of cardiovascular (CV) disease is fuelled by obesity, hypertension and diabetes and, independently and cumulatively, by an aging population. Extensive research identified immunoinflammatory mechanisms as key drivers in the initiation and progression of the disease, from early asymptomatic stages of vascular and myocardial injury leading to the clinically manifest dysfunction and remodeling in advanced stages. Underlying processes include endothelial dysfunction and extracellular matrix restructuration leading to increased vascular stiffness, as well as myocardial remodeling with dilatation and wall thinning. In this, overproduction of tumor necrosis factor-α, amongst others, contributes to generalized CV injury and dysfunction. Moreover, recent insights into the involvement of innate and adaptive immunity in atherosclerosis have shed light on many interesting parallels with chronic systemic inflammatory conditions, such as rheumatoid arthritis, with aggravated inflammation-induced vascular and myocardial injury. Besides, chronologic age has been identified as a potent, independent risk for reduced CV capacity and a plethora of heart diseases, with other modifiable risk factors acting as accelerators. We discuss the available evidence and propose that characterization of inflammatory CV responses might reveal a distinctive CV inflammatory phenotype. A comprehensive noninvasive bio-signature, comprising immunomic biomarkers and integrated noninvasive imaging, may serve as a potential tool in the early diagnosis and prognostication of CV risk.
Improving simultaneous saccharification and co-fermentation of pretreated wheat straw using both enzyme and substrate feeding (2010)

A combination of enzyme and substrate feeding was shown to enhance xylose uptake by yeast and increase overall ethanol yield in SSCF. This is conceptually important for the design of novel SSCF processes aiming at high-ethanol titers. Substrate feeding prevents viscosity from becoming too high and thereby allows a higher total amount of WIS to be added in the process. The enzyme feeding, furthermore, enables keeping the glucose concentration low, which kinetically favors xylose uptake and results in a higher xylose conversion.
Uptake of Circulating Insulin-Like Growth Factors (IGFs) into Cerebrospinal Fluid Appears to Be Independent of the IGF Receptors as Well as IGF-Binding Proteins**This work was supported by Centers for Disease Control and Prevention Grant R49/CCR811509. (2001)

Peripheral administration of human insulin-like growth factor (hIGF) results in both uptake of hIGF into the cerebrospinal fluid (CSF) and amelioration of brain injury. We tested the hypotheses that IGF uptake into CSF is independent of IGF receptors and IGF-binding proteins (IGFBP). Adult rats were injected sc with various concentrations of hIGF-I or structural analogs, and serum and CSF were withdrawn for assay 90 min later. An enzyme-linked immunoassay was used that detected immunoreactive hIGF-I and its analogs, but not rat IGF-I, IGF-II, or insulin. Plasma hIGF-I levels increased linearly (r = 0.97) with hIGF-I dose between 25-300 microgram/rat. By contrast, uptake into CSF reached saturation above 100 microgram, suggesting carrier-mediated uptake. hIGF-II reduced the uptake of hIGF-I into CSF (P < 0.02). Des(1-3)hIGF-I is a hIGF-I analog missing the N-terminal tripeptide, resulting in greatly reduced affinity for IGFBP-1, -3, -4, and -5. Nevertheless, des(1-3)hIGF-I was taken up into CSF. [Leu(24)]hIGF-I and [Leu(60)]hIGF-I have 20- to 85-fold reduced affinity for the type I IGF receptor, yet both were taken up into CSF in amounts similar to hIGF-I. In addition, hIGF-I and des(1-3)hIGF-I were taken up into CSF, although binding to the type II receptor is extremely weak. These data suggest that uptake of circulating IGF-I into CSF is independent of the type I or II IGF receptors as well as IGF sequestration to IGFBP-1, -3, -4, or -5.
STRESS SENSITIVITY OF SATURATION AND END-POINT RELATIVE PERMEABILITIES (2001)

Production induced changes in stress due to reductions in pore pressure have the potential to alter the flow properties of reservoir rocks. There are a large number of experimental results, which show that single-phase permeability is a function of applied stress. In hydrocarbon reservoirs two or even three phases may flow simultaneously through the pore network, however very little data exists on the stress sensitivity of multiphase flow. To measure the stress sensitivity of two-phase flow, the relative permeability of a sandstone was measured as a function of applied stress. The sandstone was an aeolean sandstone from a surface deposit. The sandstone was strongly water wet with an AmottHarvey index of 0.91. The porosity of the samples were between 25.4 and 28.0% and the Klinkenberg corrected gas permeability between 1051 and 1644mD. Samples were saturated with brine under high pressure, flooded with oil at different stresses to an equilibrium initial water saturation, then waterflooded to residual oil saturation. The average water saturation or oil saturation in the sample was calculated from the volume of brine or oil produced. The initial water saturation was stress sensitive in all cores tested. During the dynamic desaturation of a sample at a given stress equilibrium water saturation was reached between 2 and 8 pore volumes of injected oil. The stress was then increased and a new equilibrium water saturation reached. At an injection rate of 40ml/hr water saturations of approximately 0.400 were achieved at 400psi, this dropped to 0.385 at 3000psi and 0.377 at 8000psi. The variation of water saturation with stress can be qualitatively explained in terms of the changing pore volume and the balance between capillary and viscous forces. At a given stress and injection rate there is a balance between the capillary and viscous forces in the pores. The flowing oil is excluded from pores below a certain size by capillary forces. When the stress is increased the entire pore network deforms. Brine is squeezed out of small brine filled pores into the larger pores, where it is swept out of the sample. The effective permeability end points ko(Swi ) and kw(Sor) were stress sensitive, more so than the single phase permeability. A 15% drop in ko(Swi ) was noted from 400-3000psi. This compares to an 8% drop in the single-phase permeability of this material. This shows that the end point relative permeabilities were also stress sensitive.
Synthesis of aliphatic dimeric N-isopropylhydroxamic acids and the crystal and molecular structure of N,N'-dihydroxy-N,N'-diisopropylhexanediamide: a hydroxamic acid in the trans conformation (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of aliphatic dimeric N-isopropylhydroxamic acids and the crystal and molecular structure of N,N'-dihydroxy-N,N'-diisopropylhexanediamide: a hydroxamic acid in the trans conformationWilliam L. Smith and Kenneth N. RaymondCite this: J. Am. Chem. Soc. 1980, 102, 4, 1252–1255Publication Date (Print):February 1, 1980Publication History Published online1 May 2002Published inissue 1 February 1980https://pubs.acs.org/doi/10.1021/ja00524a006https://doi.org/10.1021/ja00524a006research-articleACS PublicationsRequest reuse permissionsArticle Views195Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Reconstruction of speech from whispers. (2001)

This paper investigates a method for the real-time reconstruction of normal speech from whispers. This system could be used by aphonic individuals as a voice prosthesis. It could also provide improved verbal communication when normal speech is not appropriate. The normal speech is synthesized using the mixed excitation linear prediction model. Differences between whispered and phonated speech are discussed and methods for estimating the parameters of this model from whispered speech for real-time synthesis are proposed. This includes smoothing the noisy linear prediction spectra, modifying the formants, and synthesizing of the excitation signal. Trade-offs between computational complexity, delay, and accuracy of different methods are discussed.
ChemInform Abstract: Computational Study on the Conformations of Dopamine, Its α‐ and ortho‐Methylated Derivatives and Their N‐Protonated Forms. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
[Embolization of the foramen ovale in metastatic course of abdominal liposarcoma]. (1991)

The authors report a case of embolization of the foramen ovale by a liposarcoma metastasis in a young woman of 28 years of age. Cardiac impact due to the progress of this rare tumor type remains unusual. The various clinical situations resulting from secondary cardiac locations are recalled. The diagnostic role of ultrasonography and the information which can be provided by nuclear magnetic resonance imaging in this context are also recalled.
Diagnostic potential of plasma microRNA signatures in patients with deep-vein thrombosis (2016)

For excluding deep-vein thrombosis (DVT), a negative D-dimer and low clinical probability are used to rule out DVT. Circulating microRNAs (miRNAs) are stably present in the plasma, serum and other body fluids. Their diagnostic function has been investigated in many diseases but not in DVT. The aims of present study were to assess the diagnostic ability of plasma miRNAs in DVT and to examine their correlation with known markers of hypercoagulability, such as D-dimer and APC-PCI complex. Plasma samples were obtained from 238 patients (aged 16-95 years) with suspected DVT included in a prospective multicentre management study (SCORE). We first performed miRNA screening of plasma samples from three plasma pools containing plasma from 12 patients with DVT and three plasma pools containing plasma from 12 patients without DVT using a microRNA Ready-to-use PCR Panel comprising 742 miRNA primer sets. Thirteen miRNAs that differentially expressed were further investigated by quantitative real-time (qRT)-PCR in the entire cohort. The plasma level of miR-424-5p (p=0.01) were significantly higher, whereas the levels of miR-136-5p (p=0.03) were significantly lower in DVT patients compared to patients without DVT. Receiver-operating characteristic curve analysis showed the area under the curve (AUC) values of 0.63 for miR-424-5p and 0.60 for miR-136-5p. The plasma level of miR-424-5p was associated with both D-dimer and APC-PCI complex levels (p<0.0001 and p=0.001, respectively). In conclusions, these findings indicate that certain miRNAs are associated with DVT and markers of hypercoagulability, though their diagnostic abilities are probably too low.
Large field of view macroscopic Raman line-scanning imaging system for neuro-oncology applications (Conference Presentation) (2020)

We present the development and preliminary results of a novel intraoperative line-scanning Raman imaging system, developed for neurosurgery applications. The system records fingerprint Raman spectral images over a large field of view of 1.0cm2 through a handheld imaging probe placed in gentle contact with the interrogated tissue. With a spatial resolution of 250µm2 and an acquisition time on the order of 10s, brain structure margins can be identified within an adequate timeframe for clinical applications. The system was designed using detailed optical simulations and its performance was verified on tissue phantoms and in vivo on animals using our laboratory’s Raman point system as reference.