gebhart/patrepeval huggingface dataset:
Growth hormone-releasing hormone antagonist MZ-4-71 inhibits in vivo proliferation of Caki-I renal adenocarcinoma (1997)

In view of evidence that growth hormone (GH) and insulin-like growth factors (IGF) may play a role in the development of renal cell carcinoma (RCC), we investigated the effects of growth hormone-releasing hormone (GH-RH) antagonist MZ-4-71 on the proliferation of the human renal adenocarcinoma cell line Caki-I in vitro and in vivo. Male nude mice bearing xenografts of human Caki-I RCC were treated for 4 weeks with MZ-4-71 injected s.c. twice daily at a dose of 20 microg per animal. Tumor growth, serum, liver, and tumor IGF levels and IGF-I receptor concentrations in Caki-I cell membranes were measured. After 4 weeks of therapy, the final volume of Caki-I tumors in nude mice treated with MZ-4-71 was significantly (P < 0.01) decreased to 52.6 +/- 12.3 mm3 as compared with controls that measured 504.2 +/- 104.1 mm3. Treatment with GH-RH antagonist also significantly reduced tumor weight, serum levels of GH and IGF-I, liver concentrations of IGF-I, and tumor levels of IGF-I and IGF-II. High-affinity binding sites for IGF-I were detected in the cell membranes of Caki-I tumors. IGF-I and IGF-II stimulated the proliferation of Caki-I cells in tissue cultures. Antagonist MZ-4-71 could inhibit in vitro growth of Caki-I cells, but only at high concentrations. Our findings demonstrate that GH-RH antagonist MZ-4-71 can significantly inhibit the growth of Caki-I RCC. MZ-4-71 may exert its suppressive effect on tumor growth through a reduction in GH release from the pituitary and the subsequent decrease in the production of IGF-I in the liver and IGF-I and II by the tumors. The efficacy of MZ-4-71 suggests that this compound could be considered for the therapy of recurrent or metastatic RCC.
Correlation Among Piecewise Unwanted Traffic Time Series (2008)

In this paper, we investigate temporal and spatial correlations of time series of unwanted traffic (i.e., darknet or network telescope traffic) in order to estimate statistical behavior of unwanted activities from a small size of darknet address block. First, from the analysis of long-range dependency, we point out that TCP time series has a weak temporal correlation though UDP time series without huge flooding is well-modeled using a Poisson process. Next, we analyze the spatial correlation between two traffic time series divided by different sized darknet address blocks. We confirm that a TCP SYN traffic time series (e.g, virus or worm) has a clear spatial correlation in the arrival of packets between two neighboring address blocks. Indeed, this spatial correlation remains in traffic time series 1,000 addresses far from the target time series, even if a darknet address block is small (e.g., /26). On the other hand, TCP SYNACK traffic (e.g., backscatter) and UDP traffic (e.g., virus or worm) have less spatial correlation between two adjacent large address blocks. Finally, we estimate the average propagation delay of global unwanted activities appearing in TCP SYN traffic by using the generalized inter-correlation coefficient.
Idiopathic osteoporosis: a heterogeneous entity. (1998)

No specific therapy has been proven to be effective in these patients. However, an individualized approach based on an assessment of bone turnover may be reasonable and may decrease the bone loss and subsequent fracture risk.
Validation of the Functional Assessment of Multiple Sclerosis quality of life instrument (1996)

Based on scientific literature and interviews with clinicians and patients, we developed a quality of life instrument for use with people with MS called the Functional Assessment of Multiple Sclerosis (FAMS). The initial item pool consisted of 88 questions: 28 from the general version of the Functional Assessment of Cancer Therapy quality of life instrument, plus 60 generated by patients, providers, and literature review. The validation samples comprised a mail survey cohort (N = 377) and a clinical cohort (N = 56). Both cohorts provides evidence for internal consistency of the derived subscales, test-retest reliability, content validity, concurrent validity, and construct validity. Principal components and Rasch measurement model analyses were applied sequentially to survey sample data, reducing test length to 44 questions, divided into six subscales: mobility, symptoms, emotional well-being (depression), general contentment, thinking/fatigue, and family/social well-being. Fifteen initially rejected questions were added back as miscellaneous (unscored) questions for their potential clinical and empirical value. The mobility subscale was strongly predictive of the Kurtzke Extended Disability Status Scale and the Scripps Neurologic Rating Scales. The other five subscales were not, indicating they measure aspects of patient quality of life not captured by the neurologic exam. The final 59-item English language instrument (FAMS version 2) is available for inclusion in clinical trials and clinical practice.
Sub-Axial Cervical Spine Instability Following Unilateral Facet Injury: A Biomechanical Analysis (2010)

Unilateral facet injuries are relatively common in the sub-axial cervical spine. Facet fractures, capsular disruptions, and posterior ligament tears can all contribute to this type of injury resulting in a range of instability spanning undisplaced fractures to complete unilateral dislocations [1]. For a particular injury pattern, considerable variability exists in the choice of treatment, and the modality selected is frequently based on surgeon preference [2]. This is due, in part, to a lack of biomechanical studies focused on increasing the understanding of changes in spinal stability that occur following cervical spine injury.
Alleviation of Neuropathic Pain Hypersensitivity by Inhibiting Neuronal Pentraxin 1 in the Rostral Ventromedial Medulla (2012)

Peripheral nerve injury causes spontaneous and long-lasting pain, hyperalgesia, and allodynia. Excitatory amino acid receptor-dependent increases in descending facilitatory drive from the brainstem rostral ventromedial medulla (RVM) contribute to injury-evoked hypersensitivity. Although increased excitability likely reflects changes in synaptic efficacy, the cellular mechanisms underlying injury-induced synaptic plasticity are poorly understood. Neuronal pentraxin 1 (NP1), a protein with exclusive CNS expression, is implicated in synaptogenesis and AMPA receptor recruitment to immature synapses. Its role in the adult brain and in descending pain facilitation is unknown. Here, we use the spared nerve injury (SNI) model in rodents to examine this issue. We show that SNI increases RVM NP1 expression and constitutive deletion or silencing NP1 in the RVM, before or after SNI, attenuates allodynia and hyperalgesia in rats. Selective rescue of RVM NP1 expression restores behavioral hypersensitivity of knock-out mice, demonstrating a key role of RVM NP1 in the pathogenesis of neuropathic pain.
Virtual Global Transplant Laboratory Standard Operating Protocol for Donor Alloantigen-specific Interferon-gamma ELISPOT Assay (2016)

The quantification of frequency of IFN-γ-producing T cells responding to donor alloantigen using the IFN-γ enzyme linked immunosorbent spot (ELISPOT) holds potential for pretransplant and posttransplant immunological risk stratification. The effectiveness of this assay, and the ability to compare results generated by different studies, is dependent on the utilization of a standardized operating procedure (SOP). Key factors in assay standardization include the identification of primary and secondary antibody pairs, and the reading of the ELISPOT plate with a standardized automated algorithm. Here, we describe in detail, an SOP that should provide low coefficient of variation results. For multicenter trials, it is recommended that groups perform the ELISPOT assays locally but use a centralized ELISPOT reading facility, as this has been shown to be beneficial in reducing coefficient of variation between laboratories even when the SOP is strictly adhered to.
Activity of Platinum-Based Chemotherapy in Patients With Advanced Prostate Cancer With and Without DNA Repair Gene Aberrations (2020)

In this study, platinum-based treatment was associated with relevant antitumor activity in a biomarker-positive population of patients with advanced prostate cancer with DNA repair gene aberrations. The findings of this study suggest that platinum-based treatment may be considered an option for these patients.
Low Content of Cyclosporine A and Its Metabolites in the Colostrum of Post-Transplant Mothers (2020)

The rate of post-transplant mothers who breastfeed while on immunosuppression is progressively increasing. Data on breastfeeding while on cyclosporine-based regimens are limited. Therefore, we assessed the amount of cyclosporine and its metabolites that might be ingested by a breastfed infant by measuring the concentration of cyclosporine and its metabolites in the colostrum of seven post-transplant mothers. The mean concentration of cyclosporine in the colostrum was 22.40 ± 9.43 mcg/L, and the estimated mean daily dose of the drug was 1049.22 ± 397.41 ng/kg/24 h. Only three metabolites (AM1, DHCsA, and THCsA) had mean colostrum amounts comparable to or higher than cyclosporine itself, with the daily doses being 468.51 ± 80.37, 2757.79 ± 1926.11, and 1044.76 ± 948.56 ng/kg/24 h, respectively. Our results indicate a low transfer of cyclosporine and its metabolites into the colostrum in the first two days postpartum and confirm the emerging change to the policy on breastfeeding among post-transplant mothers. A full assessment of the safety of immunosuppressant exposure via breastmilk will require further studies with long-term follow-ups of breastfed children.
The Aerodynamics and Near Wake of an Offshore Floating Horizontal Axis Wind Turbine (2022)

Offshore floating wind turbines represent the future of wind energy. However, significant challenges must be overcome before these systems can be widely used. Because of the dynamics of offshore floating wind turbines -- surge, sway, heave, roll, pitch, and yaw -- and the resulting interactions between the rotor and generated wake, the aerodynamic analysis methods and design codes that have found wide use throughout the wind energy industry may be inadequate. Application of these techniques to offshore floating wind turbine aerodynamics may result in off-optimal designs, effectively handicapping these next-generation systems, thereby minimizing their full potential. This dissertation will demonstrate that the aerodynamics of offshore floating wind turbines are sufficiently different from conventional offshore and onshore wind turbines, warranting the use of higher fidelity analysis approaches. It will outline the development and validation of a free vortex wake code, the Wake Induced Dynamics Simulator, or WInDS, which uses a more physically realistic Lagrangian approach to modeling complex rotor-wake interactions. Finally, results from WInDS simulations of various offshore floating wind turbines under different load conditions will be presented. The simulation results indicate that offshore floating wind turbine aerodynamics are more complex than conventional offshore or onshore wind turbines and require higher fidelity analysis approaches to model adequately. Additionally, platform pitching modes appear to drive the most aerodynamically-significant motions, followed by yawing modes. Momentum balance approaches are shown to be unable to accurately model these dynamic systems, and the associated dynamic inflow methods respond to velocity changes at the rotor incorrectly. Future offshore floating wind turbine designs should strive to either minimize platform motions or be complementarily optimized, via higher fidelity aerodynamic analysis techniques, to account for them. It is believed that this dissertation is the first in-depth study of offshore floating wind turbine aerodynamics and the applicability of various analysis methods.
Effect of Irradiation on Early Enzymatic Changes in Healing Mandibular Periosteum and Bone a Histochemical Study on Rats (1986)

The influence of irradiation was studied histochemically in healing mandibular periosteum and bone. After a cut line had been made on both sides of the mandible the rats were exposed to roentgen ray irradiation. The single doses were 15, 20, 30, 35 or 40 Gy. The animals were killed 1, 2, 4, 8, 10, 12, 16 and 24 hours after irradiation, for histochemical analysis. All enzymes, acid phosphatase, cytochrome oxidase, lactate, isocitrate, glucose-6-phosphatase and succinate dehydrogenase, showed a greater increase in enzyme staining in the irradiated cut lines than in the non-irradiated control lines. The intensity of the staining increased with time and dose over 24 hours. The observation time included an inflammatory phase with vascular, enzymatic and cellular responses to periosteal and bone injury. The increase in staining was dependent on the time after surgical trauma and radiation dose. The increase in enzyme staining probably represents the initial cell damage after irradiation.
Phase 2b Randomized Trial of the Oral PCSK9 Inhibitor MK-0616 (2023)

MK-0616 demonstrated statistically significant and robust, dose-dependent placebo-adjusted reductions in LDL-C at Week 8 of up to 60.9% from baseline and was well tolerated during 8 weeks of treatment and an additional 8 weeks of follow-up. (A Study of the Efficacy and Safety of MK-0616 [Oral PCSK9 Inhibitor] in Adults With Hypercholesterolemia [MK-0616-008]; NCT05261126).
Integrated Global Digital Image Correlation for Interface Delamination Characterization (2013)

Interfacial delamination is a key reliability challenge in composites and micro-electronic systems due to (high-density) integration of dissimilar materials. Predictive finite element models are used to minimize delamination failures during design, but require accurate interface models to capture (irreversible) crack initiation and propagation behavior observed in experiments. Therefore, an Integrated Global Digital Image Correlation (I-GDIC) strategy is developed for accurate determination of mechanical interface behavior from in-situ delamination experiments. Recently, a novel miniature delamination setup was presented that enables in-situ microscopic characterization of interface delamination while sensitively measuring global load–displacement curves for all mode mixities. Nevertheless, extraction of detailed mechanical interface behavior from measured images is challenging, because deformations are tiny and measurement noise large. Therefore, an advanced I-GDIC methodology is developed which correlates the image patterns by only deforming the images using kinematically-admissible ‘eigenmodes’ that correspond to the few parameters controlling the interface tractions in an analytic description of the crack tip deformation field, thereby greatly enhancing accuracy and robustness. This method is validated on virtual delamination experiments, simulated using a recently developed self-adaptive cohesive zone (CZ) finite element framework.
Notizen: Zur Nichtlinearität der Dielektrizitätskonstante in Flüssigkeiten (1967)

4) C,02* + C0 3 C (2') C,02* -+C02 + C (3'
Bacterial skin colonization and infections in patients with atopic dermatitis (2012)

Atopic Dermatitis is a chronic inflammatory skin disease that affects a large number of children and adults. The disease results from an interaction between genetic predisposition, host environment, skin barrier defects, and immunological factors. A major aggravating factor associated with Atopic Dermatitis is the presence of microorganisms on the patient's skin surface. Staphylococcus aureus and Streptococcus pyogenes, for instance, can exacerbate chronic skin inflammation. As a result, antimicrobials have often been prescribed to control the acute phase of the disease. However, increased bacterial resistance to antimicrobial agents has made it difficult for dermatologists to prescribe appropriate medication. In the presence of disseminated dermatitis with secondary infection, systemic antibiotics need to be prescribed; however, treatment should be individualized, in an attempt to find the most effective antibiotic with fewer side effects. Also, the medication should be used for as short as possible in order to minimize bacterial resistance.
A 4.35Gb/s/pin LPDDR4 I/O interface with multi-VOH level, equalization scheme, and duty-training circuit for mobile applications (2015)

A 4.35Gb/s/pin LPDDR4 I/O interface with multi-VOH level, equalization scheme and Duty-Training Circuit (DTC) is presented. A Low Voltage-Swing Terminated Logic (LVSTL) driver using 4-to-1 multiplexer is implemented to the transmitter. A DTC to adjust the CK duty is implemented to the receiver. In addition, a ZQ calibration scheme for Multi-VOH level is also presented. Designed schemes are compatible with the LPDDR4 standard. Power efficiency for the I/O interface is about 2.3mW/Gb/s/pin with 1.1V supply in 2y-nm DRAM process, which is 31% lower than that of LPDDR3.
Cloning and Characterization of Plasmodium falciparum FCR-3/FMG Strain * (1985)

The FCR-3/FMG African strain of Plasmodium falciparum was cloned by the limiting dilution technique in in vitro culture to obtain parasite populations derived from a single cell. The basic in vitro culture technique used was that of Trager and Jensen, performed in microtiter culture plates. The cloning sequence was repeated serially three times, and three parasite clones with a higher than 99% probability of single cell derivation were isolated. Two of these clones were determined by electron microscopic examination to possess the K+ and one the K- trait. The clones were found to be equally sensitive to chloroquine in vitro but varied in their in vivo pathogenicity for Aotus, the K- clone being non-pathogenic.
InAsSb-Based Infrared Photodetectors: Thirty Years Later On (2020)

In 1989, one author of this paper (A.R.) published the very first review paper on InAsSb infrared detectors. During the last thirty years, many scientific breakthroughs and technological advances for InAsSb-based photodetectors have been made. Progress in advanced epitaxial methods contributed considerably to the InAsSb improvement. Current efforts are directed towards the photodetector's cut-off wavelength extension beyond lattice-available and lattice-strained binary substrates. It is suspected that further improvement of metamorphic buffers for epitaxial layers will lead to lower-cost InAsSb-based focal plane arrays on large-area alternative substrates like GaAs and silicon. Most photodetector reports in the last decade are devoted to the heterostructure and barrier architectures operating in high operating temperature conditions. In the paper, at first InAsSb growth methods are briefly described. Next, the fundamental material properties are reviewed, stressing electrical and optical aspects limiting the photodetector performance. The last part of the paper highlights new ideas in design of InAsSb-based bulk and superlattice infrared detectors and focal plane arrays. Their performance is compared with the state-of-the-art infrared detector technologies.
Do Sex-Related Differences in Response to Environmental Variation Influence the Sex-Ratio in the Dioecious Rumex acetosella? (1994)

Populations of the dioecious herb Rumex acetosella show variation in sex ratio along an old-field successional gradient in central France, where female-biased or 50:50 ratios occur in young populations and male-biased ratios occur in old populations. In order to test the hypothesis that differences in environmental sensitivity and/or reproductive biology account for sex related differences in habitat occupation of this species, two complementary experiments were performed. First, the environmental sensitivity (or reaction norms) of biomass allocation for male and female plants was examined over an experimental gradient of density and nutrients to test whether the sexes differ in habitat preference (...)
Selective Derivatization and Characterization of Bifunctional “Janus-Type” Cyclotetrasiloxanes (2013)

Stereoregular all-cis cyclotetrasiloxanes [R-Si(O)-R′]4 with different functional groups attached to the opposite faces of the ring skeleton were derivatized without stereoisomerization or cleavage of the (SiO)4 ring and with high selectivity using standard synthetic methods. The solid-state structures obtained for the iodophenyl-substituted starting material 16 ([p-I-C6H4-Si(O)-OSiMe2Vin]4) and for the coupling product 21 ([biphenyl-CC-C6H4-Si(O)-OSiMe2Vin]4) show a pronounced differentiation in the steric requirements of the different sides of the ring, resulting in characteristic crystal packing. In combination with the observed high thermal and chemical stability, these data demonstrate the high potential of cyclotetrasiloxanes for a wide range of applications.
Application of Cell Culture Systems to the Study of Drug Transport and Metabolism (1995)

In recent years, pharmaceutical scientists have begun to develop and validate cell culture systems that mimic the biological barriers that prevent a drug from reaching its pharmacological target. This article reviews the cell culture systems that have been developed to mimic the intestinal, nasal and pulmonary epithelium and the brain vascular endothelium. Examples of how these cell culture systems are used to elucidate pathways of drug transport and metabolism and how they are used to evaluate strategies to enhance drug permeability and minimize drug metabolism are given.
A 120nW 18.5kHz RC oscillator with comparator offset cancellation for &#x00B1;0.25% temperature stability (2013)

Integrated low-frequency oscillators can replace crystal oscillators as sleep-mode timers to reduce the size and cost of wireless sensors [1]. Since the timer is one of the few continuously functioning circuits, minimizing its power consumption can greatly reduce sleep-mode power of highly duty-cycled systems. Temperature stability of the oscillator is important in order to minimize timing uncertainly and guard time for the radios, and thus maximizing sleep time. The voltage-averaging feedback method described in [2] achieves high stability in the MHz frequencies, but when scaled to the kHz range, requires very large filters. On the other extreme, gate leakage-based timers have been designed for sub-nW power consumption, but operate in the sub-Hz frequencies [3]. In the past, high accuracy RC oscillators in the kHz range have been designed with feed-forward correction [1] and self-chopped operation [4]. In this work, an offset cancellation architecture achieves long-term frequency stability and temperature stability while operating at lower power.
Thresholds for transient cavitation produced by pulsed ultrasound in a controlled nuclei environment (1990)

Transient cavitation is a discrete phenomenon that relies on the existence of stabilized nuclei, or pockets of gas within a host fluid, for its genesis. A convenient descriptor for assessing the likelihood of transient cavitation is the threshold pressure, or the minimum acoustic pressure necessary to initiate bubble growth and subsequent collapse. An automated experimental apparatus has been developed to determine thresholds for cavitation produced in a fluid by short tone bursts of ultrasound at 0.76, 0.99, and 2.30 MHz. A fluid jet was used to convect potential cavitation nuclei through the focal region of the insonifying transducer. Potential nuclei tested include 1-microns polystyrene spheres, microbubbles in the 1- to 10-microns range that are stabilized with human serum albumin, and whole blood constituents. Cavitation was detected by a passive acoustical technique that is sensitive to sound scattered from cavitation bubbles. Measurements of the transient cavitation threshold in water, in a fluid of higher viscosity, and in diluted whole blood are presented. These experimental measurements of cavitation thresholds elucidate the importance of ultrasound, host fluid, and nuclei parameters in determining these thresholds. These results are interpreted in the context of an approximate analytical theory for the prediction of the onset of cavitation.