gebhart/patrepeval huggingface dataset:
Lead-Free Halide Light-Emitting Diodes with External Quantum Efficiency Exceeding 7% Using Host–Dopant Strategy (2021)

Lead-free halide light-emitting diodes (LEDs) are fabricated using nontoxic and earth-abundant CsCu2I3 with a strong yellow emission at a peak wavelength of 568 nm. CsCu2I3-based host–dopant emitters are formed by vacuum thermal evaporation (VTE) film codeposition process instead of the commonly used solution-based film deposition process. Using the VTE process, extremely thin (30 nm) host–dopant emitters have successfully been formed with the CsCu2I3 dopant and various organic host molecules. A bright yellow emission with a photoluminescence quantum yield value of 84.8% is achieved in the 0.5% CsCu2I3-doped halide emitter film due to the successful spatial localization of charge carriers and excitons using an organic host with appropriate energy levels to CsCu2I3. With the further enhancement in charge balance using the cohost system, a record-breaking lead-free halide LED has been fabricated with an EQE of 7.4%. The lead-free halide LEDs are also highly stable in the device operation with LT70 of 20 h at 100 cd/m2.
Contact Thermal Analysis and Wear Simulation of a Brake Block (2013)

The present paper describes an experimental test and a coupled contact-thermal-wear analysis of a railway wheel/brake block system through the braking process. During the test, the friction, the generated heat, and the wear were evaluated. It was found that the contact between the brake block and the wheel occurs in relatively small and slowly moving hot spots, caused by the wear and the thermal effects. A coupled simulation method was developed including numerical frictional contact, transient thermal and incremental wear calculations. In the 3D simulation, the effects of the friction, the thermal expansion, the wear, and the temperature-dependent material properties were also considered. A good agreement was found between the results of the test and the calculations, both for the thermal and wear results. The proposed method is suitable for modelling the slowly oscillating wear caused by the thermal expansions in the contact area.
Observations on the conference: A pharmacist’s perspective (2000)

Journal Article Observations on the conference: A pharmacist’s perspective Get access Charles D. Hepler, Ph.D. Charles D. Hepler, Ph.D. Distinguished Professor and Director DuBow Family Center for Research in Pharmaceutical Care, College of Pharmacy, University of Florida, P.O. Box 100496, Gainesville, FL 32610 Search for other works by this author on: Oxford Academic Google Scholar American Journal of Health-System Pharmacy, Volume 57, Issue 6, 15 March 2000, Pages 590–594, https://doi.org/10.1093/ajhp/57.6.590 Published: 15 March 2000
Myogenic waves and myogenic programs during Xenopus embryonic myogenesis (2012)

The first median and lateral myogenesis and their associated MRF programs have probably disappeared in mammals. However, some aspects of Xenopus myogenesis have been conserved such as the development of somitic muscles by successive myogenic waves and the existence of Myf5-dependent and -independent lineages.
Multiple non-ribosomal peptide synthetase genes determine peptaibol synthesis inTrichoderma virens (2005)

Trichoderma virens, an imperfect fungus, is used as a biocontrol agent to suppress plant disease caused by soilborne fungal pathogens. Antimicrobial peptides it produces include peptaibols of 11, 14, and 18 amino acids in length. These peptaibols were previously reported to be synthesized by a non-ribosomal peptide synthetase (NRPS) encoded by the Tex1 gene in strain Tv29-8. The present study examined the Tex1 homolog in a commercially relevant T. virens strain, G20. Although the gene in G20 was 99% identical in DNA sequence to Tex1 in the 15.8 kb compared, gene disruption results indicate that it is only responsible for the production of an 18-mer peptaibol, and not 11-mer and 14-mer peptaibols. Additional NRPS adenylate domains were identified in T. virens and one was found to be part of a 5-module NRPS gene. Although the multimodule gene is not needed for peptaibol synthesis, sequence comparisons suggest that two of the individual adenylate domain clones might be part of a separate peptaibol synthesis NRPS gene. The results indicate a significant diversity of NRPS genes in T. virens that is unexpected from the literature.
Virtualization Services: Accelerated I/O Support in Multi-Core Systems (2010)

Abstract—Virtualization services permit I/O subsystems and peripheral devices to be virtualized by placing select functionality on specialized cores and/or on cores situated ‘closer ’ to devices. The approach is used to implement self-virtualized I/O (SV-IO), which off-loads certain virtualization functionality onto the cores available on the I/O device, accelerating I/O functions, efficiently using key performance-limiting resources in multicore systems, i.e., memory and I/O bandwidth, and exploiting the parallelism inherent in multi-core architectures. This paper evaluates a concrete instance of self-virtualized I/O, a selfvirtualized network interface (SV-NIC), targeting the high end NICs used in datacenters. Experimental evaluations of the SV-NIC in a prototyping environment using an IXP2400-based ethernet board show high scalability in terms of the numbers of virtual interfaces (VIFs) offered to guests, and up to ∼77% improvements in throughput and ∼53 % reductions in latency, compared to the current standard virtualized device implementations on hypervisor-based platforms. Beyond such performance advantages, the generality of virtualization services and their use for implementing enhancements to standard services are demonstrated with a storage service that provides location transparent access to block devices for guest VMs, and with enhancements to a network service that provide per-VM, prioritybased servicing of virtual network devices. I.
Thermal performance of metal-clad fiber Bragg grating sensors (1998)

We demonstrate the higher temperature sensitivity of a fiber Bragg grating (FBG) sensor when it is clad with a metal of a large thermal expansion coefficient. With lead (solder) cladding, the sensitivity of Bragg wavelength shift can be enhanced by about five (four) times. A theoretical model was adopted to show quite consistent results. It was found that thermal annealing was crucial for preparing high-quality fiber Bragg grating sensors with metal claddings.
Validation of Deep Learning-based Sleep State Classification (2022)

Deep learning methods have been developed to classify sleep states of mouse electroencephalogram (EEG) and electromyogram (EMG) recordings with accuracy reported as high as 97%. However, when applied to independent datasets, with a variety of experimental and recording conditions, sleep state classification accuracy often drops due to distributional shift. Mixture z-scoring, a pre-processing standardization of EEG/EMG signals, has been suggested to account for these variations. This study sought to validate mixture z-scoring in combination with a deep learning method on an independent dataset. The open-source software Accusleep, which implements mixture z-scoring in combination with deep learning via a convolutional neural network, was used to classify sleep states in 12, three-hour EEG/EMG recordings from mice sleeping in a head-fixed position. Mixture z-scoring with deep learning classified sleep states on two independent recordings with 85-92% accuracy and a Cohen's κ of 0.66-0.71. These results validate mixture z-scoring in combination with deep learning to classify sleep states with the potential for widespread use.
High-Yield Purification of Functionally Active Glucocorticoid Receptor (2003)

The glucocorticoid receptor (GR) resides in the cytoplasm as a complex with chaperones. Upon ligand association, GR shuttles into the nucleus, and binds to its hormone response elements to control expression of particular genes (1-7). Transcriptional regulation by GR is thought to be a consequence of macromolecular assembly formation with proteins, including chromatin remodelers, histone modifiers, coactivators, and transcriptional machinery on a promoter (1-8-17). Nucleation of this large multisubunit complex by GR homodimers results in a chromatin transition (18-23). and preinitiation complex assembly. To date, the molecular details of the GR-induced macromolecular assembly and chromatin transition are poorly understood.
Chemotherapy-induced liver injury in children (2019)

Drug-induced liver injury due to chemotherapy is an important cause of morbidity in cancer patients, although its clinical manifestations are poorly understood. The objective of the present study was to determine the characteristics (forms of presentation, severity, and type of injury) of hepatotoxicity due to chemotherapy in children treated for cancer. A total of 22 oncological patients were included in the study, after ruling out other causes of increased transaminases (infectious, metabolic, autoimmune, or hereditary), according to the CIOMS causality scale, it is concluded that it was a possible, probable or definite episode of hepatic injury by drugs. All children had more than one episode of hepatotoxicity, and a total of 98 episodes are analysed. Methotrexate was the most commonly implicated drug. The histological pattern of predominant damage was hepatocellular. Only 2 episodes were classified as serious. Idiosyncratic hepatotoxicity due to chemotherapy is frequent, with a tendency to relapse with re-exposure. Although it does not usually have important consequences, the high frequency makes it advisable to establish standardised safety algorithms with very strict monitoring of liver enzymes during high periods of risk in chemotherapy. La lesión hepática inducida por fármacos debida a quimioterapia es una causa importante de morbilidad en enfermos oncológicos aunque sus manifestaciones clínicas son poco conocidas. El objetivo del presente estudio fue determinar las características (formas de presentación, gravedad y tipo de lesión) de la hepatotoxicidad por quimioterapia en niños tratados por cáncer. Se incluyó en el estudio a un total de 22 enfermos oncológico en los que, tras descartar otras causas de aumento de transaminasas (infecciosa, metabólica, autoinmune o hereditaria), se concluye, según la escala de causalidad CIOMS, que se trata de un episodio posible, probable o definido de lesión hepática por fármacos. Todos los niños tuvieron más de un episodio de hepatotoxicidad, en total se analizan 98 episodios. Metotrexato fue el fármaco implicado con mayor frecuencia. El patrón histológico de daño predominante fue hepatocelular. Solo 2 episodios fueron clasificados de graves. La hepatotoxicidad idiosincrásica por quimioterapia es frecuente, la tendencia es a la recidiva con la reexposición y, aunque no suele tener consecuencias importantes, la elevada frecuencia hace aconsejable establecer algoritmos de seguridad estandarizados con controles muy estrictos de enzimas hepáticas durante los períodos de alto riesgo de quimioterapia.
Epoxy Cross-Linked Polyamine CO2 Sorbents Enhanced via Hydrophobic Functionalization (2019)

Optimizing sorption capacity and amine efficiency are among the major challenges in developing solid carbon dioxide sorbents. Such materials frequently feature polyamines impregnated onto supports adding weight to the sorbents. This work presents the cross-linking of polyethyleneimine (PEI) by the industrially available epoxy resin, bisphenol-A diglycidyl ether (DER) to form support-free sorbent materials. Prior to cross-linking, the polyamine chain is functionalized with hydrophobic additives; one material modified with the branched chain hydrocarbon 2-ethylhexyl glycidyl ether displays a CO2 uptake of 0.195 g/g, 4.43 mmol CO2/g (1 atm single component CO2, 90 °C). The additive loading affects the cross-linking, with the lesser cross-linked materials showing more favorable sorption capacities and higher amine efficiencies. The type of additive also influences sorption, with the larger, longer and bulkier additives better able to free the amines from their hydrogen bonding network, generally promoting better sorption. In addition to increasing CO2 uptake, the additives also reduce the optimum sorption temperature, offering a handle to tune sorbents for specific working conditions. The best performing material shows high selectivity for CO2 sorption, and under sorption cycles in a 10% CO2/90% N2 mixture, utilizing temperature swing desorption, demonstrates a good working capacity of 9.5% CO2 uptake over the course of 29 cycles. Furthermore, humidity has been found to promote CO2 sorption at lower temperatures with a CO2 uptake of 0.235 g/g, 5.34 mmol/g (1 atm single component CO2, 25 °C) using a prehydrated sample. Overall, these findings confirm the value of our approach where cross-linking emerges as a valid and practical alternative to loading polyamines onto solid supports. This work demonstrates the versatility of these types of materials and their potential for use in large-scale carbon capture systems.
In Vitro Selection and Characterization of Human Immunodeficiency Virus Type 2 with Decreased Susceptibility to Lopinavir (2007)

Lopinavir (LPV)-ritonavir has demonstrated durable antiviral activity in human immunodeficiency virus type 1 (HIV-1)-infected antiretroviral-naïve and protease inhibitor (PI)-experienced patients. However, information on LPV activity against HIV-2 and the patterns of mutations in HIV-2 in response to selection by LPV is limited. The activity of LPV against three strains of HIV-2 was assessed and compared to activity against a reference HIV-1 strain. LPV demonstrated activity similar to that observed against HIV-1 in two HIV-2 strains (HIV-2(MS) and HIV-2(CBL-23)) tested. On the other hand, approximately 10-fold-reduced susceptibility was observed with the third HIV-2 strain, HIV-2(CDC310319). Passage of HIV-2(MS) with increasing concentrations of LPV selected mutations V47A and D17N in the HIV-2 protease gene. The introduction of both 17N and 47A either individually or together into HIV-2(ROD) molecular infectious clones showed that the single V47A substitution in HIV-2 resulted in a substantial reduction in susceptibility to LPV. In contrast, this mutant retained wild-type susceptibility to other PIs and appeared to be hypersusceptible to atazanavir and saquinavir.
Two-Stream Transformer Networks for Video-Based Face Alignment (2017)

In this paper, we propose a two-stream transformer networks (TSTN) approach for video-based face alignment. Unlike conventional image-based face alignment approaches which cannot explicitly model the temporal dependency in videos and motivated by the fact that consistent movements of facial landmarks usually occur across consecutive frames, our TSTN aims to capture the complementary information of both the spatial appearance on still frames and the temporal consistency information across frames. To achieve this, we develop a two-stream architecture, which decomposes the video-based face alignment into spatial and temporal streams accordingly. Specifically, the spatial stream aims to transform the facial image to the landmark positions by preserving the holistic facial shape structure. Accordingly, the temporal stream encodes the video input as active appearance codes, where the temporal consistency information across frames is captured to help shape refinements. Experimental results on the benchmarking video-based face alignment datasets show very competitive performance of our method in comparisons to the state-of-the-arts.
A computationally efficient approach to microwave circuit modeling of complex high temperature superconductor circuits (1997)

A computationally efficient approach to modeling complex high temperature superconductor (HTS) microwave circuits is described which combines two-dimensional electromagnetic solutions of microwave transmission lines, incorporating a phenomenological description of HTS behavior, with conventional commercially available microwave-circuit computer-aided-design software. Internal inductance effects are known to have a substantial impact on the design and implementation of narrowband HTS circuits. Phase velocities and characteristic impedances can be well modeled using a phenomenological description of HTS superconductivity along with a generalized approximate boundary condition and a two dimensional electro-magnetic solution to the waveguiding structure. Resultant parameterized design equations can then be incorporated into standard commercially available microwave-circuit computer-aided-design software. The test case examined in detail was the superconducting channelized receiver delivered by the Naval Research Laboratory to Phase II of the High Temperature Superconducting Space Experiment. Excellent agreement was obtained between measurements made on the demultiplexer and this HTS microwave circuit modeling approach.
Development of a Simple and Efficient Method for Preconcentration and Determination of Trace Levels of Fexofenadine in Plasma and Urine Samples (2016)

A simple, inexpensive and sensitive three-phase hollow fiber liquid-phase microextraction (HFLPME) coupled with high performance liquid chromatography (HPLC) with UV detection was successfully developed for determination of trace level of an anti-Histamine drug, fexofenadine, in human plasma and urine. The analyte was extracted into n-octanol that was immobilized in the wall of a porous hollow fiber from 15 mL of aqueous sample, with pH 4 (donor phase), and was back extracted into the acceptor phase with pH 9 located in the lumen of the hollow fiber. The extraction occurred due to a pH gradient between the sides of the hollow fiber. Several parameters affecting the extraction process such as type of extraction solvent, pH, salt concentration, extraction time, and stirring speed were optimized. Under the optimized conditions enrichment factor of 65, linear dynamic range (LDR) of 1.8-200 ng/mL and limit of detection (LOD) 0.6 ng/mL were obtained. The percent relative intraday and interday standard deviations (RSD%) based on 3 replicate determinations were 7.1% and 7.6% respectively
CELLULAR INTERACTIONS IN MARROW-GRAFTED PATIENTS (1984)

The proliferation of T cells of marrow donor origin in response to Escherichia coli, an ubiquitous antigen, presented by circulating monocytes of marrow donor origin was investigated in 30 human allogeneic marrow transplant recipients. Compared with cells from healthy marrow donors, T cell proliferation was found to be deficient in all recipients studied 36–71 days after grafting, regardless of the presence or absence of acute graft-versus-host disease and in most patients with chronic graft-versus-host disease studied 118–1804 days postgrafting. In contrast, lymphocytes from most long-term patients without chronic graft-versus-host disease studied 363–2673 days had immune reactivity comparable to that of lymphocytes from their marrow donors. Results of cell-mixing experiments showed that (1) monocytes from most marrow recipients were capable of presenting antigens to normal T cells of marrow donors, and (2) T cells from short-term patients and from long-term patients with active chronic graft-versus-host disease were not induced to proliferate by E-coli-pulsed monocytes from the marrow donors. This inability of T cells to proliferate was likely the result of ineffective interactions among T cell subsets.
The HLA class I-CML association revisited taking into account the two forms of gene fusion in the Philadelphia chromosome. A multicenter study. (1994)

CML patients possess either a b3-a2 or a b2-a2 fusion between the BCR and ABL genes. Depending on the type of fusion, two different series of non-self potentially immunogenic peptides may be produced. If they are presented by HLA class I molecules and recognized by cytotoxic CD8 lymphocytes, individuals could be more susceptible or resistant to leukemic cells bearing one or the other form of fusion according to their HLA class I phenotype. To test this point, the frequencies of HLA-A and HLA-B alleles were compared between b3-a2 and the b2-a2 CML patients. In essence, no difference was found whose significance could withstand correction for multiple comparisons.
Resonance Raman Spectroscopy of 0-A12O3- Supported Vanadium Oxide Catalysts for Butane Dehydrogenation (2008)

This chapter contains sections titled: Introduction; Structure of Al{sub 2}O{sub 3}-Supported Vanadia Catalysts; Quantification of Surface VOx Species on Supported Vanadia Catalysts; Conclusion; Acknowledgements; and References.
Light scattering power of randomly cut random coils with application to the determination of depolymerization rates (1989)

The scattering of light by a dilute monodisperse population of random-coil molecules is approximately described by the well-known function P(θ)=(2/u2)(e−u+u−1), where u=R2gq2, Rg is the radius of gyration of the random coils, and q=(4πn/λ)sin(θ/2) is the magnitude of the scattering vector. We show that if the molecules in this population undergo random scission, then P(θ) is still given by the above formula where, however, u is now equal to R2goq2+r, where r is the average number of scissions per molecule in the originally monodisperse population and Rgo is the original radius of gyration. It is suggested that this could be useful for determining depolymerization rate constants, and for investigating whether various forms of scission are actually random. Results from initial experiments which apply the theory to the acid hydrolysis of hyaluronic acid are presented. The rate constants found are in reasonable agreement with values in the literature.
Racemization of Individual Aspartate Residues in Human Myelin Basic Protein (1988)

Human myelin basic protein (MBP), a long-lived brain protein, undergoes gradual racemization of its amino acids, primarily aspartic acid and serine. Purified protein was treated at neutral pH with trypsin to yield peptides that were separated by HPLC using a C18 column. Twenty-nine peptides were isolated and analyzed for amino acid composition and aspartate racemization. Each aspartate and asparagine in the protein was racemized to a different extent, ranging from 2.2 to 17.1% D isomer. When the racemization was examined in terms of the beta-structure model of MBP, a correlation was observed in which six aspartate/asparagine residues assumed to be associated with myelin membrane lipids showed little racemization (2.2-4.9% D isomer), whereas five other aspartate residues were more highly racemized (9.9-17.1% D isomer). Although the observed aspartate racemization may be related to steric hindrance by neighboring residues and/or the protein secondary structure, interaction of aspartates with membrane lipids may also be a major factor. The data are compatible with a model in which each MBP molecule interacts with adjacent cytoplasmic layers of myelin membrane through a beta-sheet on one surface and loops and helices on the other surface, thereby stabilizing the myelin multilamellar structure.
[A prospective study on the association between dyslipidemia and hypertension]. (2009)

Dyslipidemia might occur before being hypertensive. Hypertension was associated with HDL-C, TC/HDL-C and TG or even exclusion of obesity, diabetes and factors of smoking and drinking or baseline level of SBP, DBP were adjusted.
Trace Elements by Instrumental Neutron Activation Analysis for Pollution Monitoring (1975)

Methods and technology were developed to analyze 1000 samples/yr of coal and other pollution-related samples. The complete trace element analysis of 20-24 samples/wk averaged 3-3.5 man-hours/sample. The computerized data reduction scheme could identify and report data on as many as 56 elements. In addition to coal, samples of fly ash, bottom ash, crude oil, fuel oil, residual oil, gasoline, jet fuel, kerosene, filtered air particulates, ore, stack scrubber water, clam tissue, crab shells, river sediment and water, and corn were analyzed. Precision of the method was ±25% based on all elements reported in coal and other sample matrices. Overall accuracy was estimated at 50%.