gebhart/patrepeval huggingface dataset:
Light–dark (12:12) cycle of carbon and nitrogen metabolism in Crocosphaera watsonii WH8501: relation to the cell cycle (2011)

This study provides with original data sets on the physiology of the unicellular diazotrophic cyanobacterium Crocosphaera watsonii WH8501, maintained in continuous culture in conditions of obligate diazotrophy. Cultures were exposed to a 12:12 light-dark regime, representative of what they experience in nature and where growth is expected to be balanced. Nitrogen and carbon metabolism were monitored at high frequency and their dynamics was compared with the cell cycle. Results reveal a daily cycle in the physiological and biochemical parameters, tightly constrained by the timely decoupled processes of N(2) fixation and carbon acquisition. The cell division rate increased concomitantly to carbon accumulation and peaked 6 h into the light. The carbon content reached a maximum at the end of the light phase. N(2) fixation occurred mostly during the dark period and peaked between 9 and 10 h into the night, while DNA synthesis, reflected by DNA fluorescence, increased until the end of the night. Consequently, cells in G1- and S-phases present a marked decrease in their C:N ratio. Nitrogen acquisition through N(2) fixation exceeded 1.3- to 3-fold the nitrogen requirements for growth, suggesting that important amounts of nitrogen are excreted even under conditions supposed to favour balanced, carbon and nitrogen acquisitions.
Psoriasis (2018)

Psoriasis, an inherited disorder of the immune system, presents most commonly in the skin and joints but is also associated with cardiovascular, metabolic, and neuropsychiatric effects. Treatments include topical therapy for mild disease; phototherapy and oral therapy, such as retinoids and immunomodulating agents; and targeted biologic therapies that have revolutionized treatment of psoriasis and psoriatic arthritis. Primary care physicians should be aware of the systemic associations of psoriasis and the treatments available for this disorder.
A multichannel, high-resolution, UV spectrometer for laser-fusion applications (2005)

A 63-channel, ultraviolet (UV) spectrometer has been designed and tested. With an input energy of 1μJ per channel, 63 spectra can be acquired simultaneously on a single, multibeam laser shot. The spectrometer has a dispersion at the detector plane of 8.6×10−2pm∕μm and a spectral window of 2.4 nm at λ=351nm. The wavelength resolution varies from 2.5 pm at the center of the field of view to 6 pm at the edge.
Expression of an Avian Protamine in Transgenic Mice Disrupts Chromatin Structure in Spermatozoa1 (1995)

The objective of this study was to determine the consequences of disrupting spermatozoal chromatin condensation on spermatozoal development and function. The avian protamine, galline, was targeted to spermatids of transgenic mice using the mouse protamine 1 gene promoter. Three transgenic mouse lines were established that expressed galline mRNA at 65%, 120%, and 185% of the level found in rooster testis. Galline mRNA accumulated in round spermatids to levels similar to that of mouse protamine and, as with the mammalian counterpart, translation was delayed until the elongating spermatid stage. Protein gels revealed that galline accumulated in mature spermatozoa whereas mouse protamines were reduced, suggesting that galline competes with protamines for binding to spermatozoal DNA. Acridine orange binding analysis indicated that DNA of the transgenic spermatozoa was not as tightly packed as that of controls. This was corroborated by electron microscopy, which revealed disruption of the normal dense chromatin structure of spermatozoal heads. Despite these perturbations of chromatin condensation, the transgenic spermatozoa were functionally normal, as the majority of transgenic mice had normal fertility. However, in mice that expressed excessive galline, there was a gradual destruction of seminiferous tubules leading to infertility. Our findings suggest that very precise packaging of DNA in germ cells may not be essential for subsequent unpackaging in the pronucleus of fertilized eggs and for subsequent normal development of the embryo.
Women Recover Faster Than Men after Standard Knee Arthroplasty (2011)

Level II, prognostic study. See the guidelines for authors for a complete description of levels of evidence.
Scale-Free Brain-Wave Music from Simultaneously EEG and fMRI Recordings (2012)

In the past years, a few methods have been developed to translate human EEG to music. In 2009, PloS One 4 e5915, we developed a method to generate scale-free brainwave music where the amplitude of EEG was translated to music pitch according to the power law followed by both of them, the period of an EEG waveform is translated directly to the duration of a note, and the logarithm of the average power change of EEG is translated to music intensity according to the Fechner's law. In this work, we proposed to adopt simultaneously-recorded fMRI signal to control the intensity of the EEG music, thus an EEG-fMRI music is generated by combining two different and simultaneous brain signals. And most importantly, this approach further realized power law for music intensity as fMRI signal follows it. Thus the EEG-fMRI music makes a step ahead in reflecting the physiological process of the scale-free brain.
A phase II study of BKM120 (buparlisib) in relapsed or refractory thymomas. (2018)

e20580 Background: For residual or metastatic thymomas, the majority of patients require second-line therapy after platinum-combination chemotherapy with response rates ranging from 0 to 20%. Prior genomic analyses of thymoma demonstrated an activated PI3K pathway in a subset of tumors. We investigated the efficacy of buparlisib, an oral pan-PI3K inhibitor, in relapsed or refractory thymomas. Methods: This was a single center, single arm, open label phase II trial of buparlisib in patients with recurrent thymoma who have progressed after at least one prior line of treatment. Subjects were treated until disease progression or unacceptable toxicity. Thymic carcinomas were excluded. The primary endpoint was objective response rate (ORR) (complete response [CR] + partial response [PR]) using the RECIST 1.1 criteria. Secondary endpoints included toxicity assessments; progression free survival (PFS); overall survival (OS); disease control rate (DCR), i.e. percentage of patients who achieve either PR or CR or stable disease [SD] for at least 4 months. Results: Between 10/13/2014 and 1/18/2017, 14 patients were enrolled. Median age was 58 y (23 – 74). 71% were females and 71% white. All patients had WHO B2 (29%) or B3 (71%) thymoma. 12 patients had stage IV disease. Patients received buparlisib for a median of 4.5 m (2 – 33). At a median follow up of 16.6 m (2.4 – 31.3), 1 patient (7%) achieved a PR that lasted 9.7 m. DCR was 50%. Median PFS was 11.1 m (95% CI 2.9 – 18.8). Median OS was 22.5 m (10.7 – 31.3). Most common grade 3-4 adverse events related to buparlisib were dyspnea (21%), rash (14%), pneumonitis (7%), anxiety (7%), fatigue (7%) and hyperglycemia (7%). Reasons for treatment discontinuation were rash (43%), pneumonitis (29%), transaminits (21%) and autoimmune cholangitis (7%). As of 1/5/2018, 5 patients have died, 4 due to disease progression and 1 due to central nervous system toxoplasmosis and autoimmune cholangitis. Conclusions: Buparlisib showed modest activity in patients with relapsed or refractory thymomas. Further investigation of PI3K pathway targeted therapy is warranted. Clinical trial information: NCT02220855.
Characterization and purification of osteogenic cells from murine bone marrow by two-color cell sorting using anti-Sca-1 monoclonal antibody and wheat germ agglutinin (1994)

Osteogenic cells were sorted from bone marrow of 5-fluorouracil (5-FU)- treated mice based on light scatter characteristics, Sca-1 expression, and their binding to wheat germ agglutinin (WGA). Four sort gates were established using forward (FSC) and perpendicular (SSC) light scatter and were denominated as FSChigh SSClow, FSClow SSChigh, FSClow SSClow, and FSChigh SSChigh cell. Cells from the FSChigh SSChigh gate, but not from the other gates, synthesized alkaline phosphatase, collagen, and osteocalcin and formed a mineralized matrix in culture. The number of osteoprogenitor cells was significantly enriched after depleting the 5- FU bone marrow from cells of the lymphoid and myeloid lineage, eg, T cells, B cells, natural killer cells, granulocytes, macrophages, and erythrocytes. Approximately 95% of the FSChigh SSChigh cell population of this “lineage-negative” (Lin-) marrow expressed the Sca-1 antigen (Sca-1+) and bound WGA. Three additional sort windows were established based on WGA binding intensity and were denominated as Sca-1+ WGAdull, Sca-1+ WGAmedium, and Sca-1+ WGAbright. Cells from the Sca-1+ WGAbright gate, but not from the other gates, synthesized bone proteins and formed a mineralized matrix. However, they lost this capacity upon subcultivation. Further immunophenotypic characterization showed that FSChigh SSChigh Lin- Sca-1+ WGAbright cells expressed stromal (KM16) and endothelial (Sab-1 and Sab-2) markers, but not hematopoietic surface markers such as c-kit and Thy1.2. Sorted FSChigh SSChigh Lin- Sca-1+ WGAbright cells form three-dimensional nodules that stain with the von Kossa technique and contain osteoblast and osteocyte-like cells.
Calcium messenger system: Role of protein phosphorylation and inositol bisphospholipids (1987)

Poovaiah, B. W., Reddy, A. S. N. and McFadden, J. J. 1987. Calcium messenger system: Role of protein phosphorylation and inositol bisphospholipids.
Response Amplitude Operator Predictions for the USS BELKNAP (DLG-26) and USS JOSEPH HEWES (DE-1052) Class Destroyers (1974)

The purpose of the investigation is to predict the response amplitude operators (squared transfer functions) for the DLG-26 and DE-1052 Class Destroyers. The response amplitude operators, RAOs, are computed for the ships in LAMPS (Light Airborne Multipurpose System) configuration and are to be used for ship motion predictions in ship/helicopter interface design. Motion response amplitude operators are presented for speeds 10 and 20 knots, at ship headings relative to the sea of 0, 30, 60, 90, 120, 150, and 180 degrees (180 degrees denoting head seas).
Inhibition by retinoids of platelet growth factor-dependent stimulation of DNA synthesis and cell division in density-arrested C3H 10T1/2 fibroblasts. (1989)

The inhibition of neoplastic transformation by vitamin A and its natural and synthetic analogues, collectively called retinoids, is accomplished by an as yet unknown mechanism. In a recent report, the morphological transformation of carcinogen-treated C3H 10T1/2 fibroblasts to focus-forming transformed cells was shown to be a postconfluence event induced in density-arrested initiated cells by platelet growth factors in serum and was correlated with the mitogenic response of the preneoplastic cells to these polypeptides. The current study investigates the possibility that the inhibition of neoplastic transformation by retinoids is accomplished by blocking the mitogenic response of initiated cells to these growth factors. The results demonstrate that the stimulation by serum of DNA synthesis and cell division in normal and carcinogen-treated C3H 10T 1/2 fibroblasts after density-dependent growth arrest is inhibited in a dose-dependent manner by retinyl acetate, all-trans retinoic acid, and 4-hydroxyphenyl-retinamide over the same dose range and to the same extent that neoplastic transformation is inhibited by these retinoids. Cellular mitogenic processes sensitive to retinoid inhibition were shown to be induced specifically by platelet growth factors, rather than plasma growth factors, to occur within approximately 2 h of growth factor treatment, and to be common to cell division stimulated in density-arrested normal and initiated cells by highly purified platelet-derived or epidermal growth factor. These data suggest that the inhibition of neoplastic transformation by retinoids is accomplished by blocking the G0 to G1 transition in the mitotic response of initiated cells to platelet growth factors which act as endogenous promoters of transformation.
The influence of whole-body vibration on noise-induced hearing loss: A review of animal experiments (1988)

There is the suggestion in the literature that vibration may potentiate the effects of noise and may pose an increased risk of hearing loss. However, in human experimental studies, which, by necessity, are limited to low levels of TTS, the effects measured are consistent but relatively small. A very limited number of animal studies have also shown an enhanced hearing loss, but the scope of these studies is limited by a large intersubject variability and a small number of subjects. Also, the high levels of stimulation that were used in some of these animal experiments were not realistic. Our recent animal studies (chinchilla) have used a 30 Hz, 3-g-rms cage vibration in combination with continuous noise (95-dB, 0.5-kHz octave band) and impact noise (113-, 119-, or 125-dB peak SPL) exposure paradigms. All exposures lasted for 5 days. The impact noise exposures were designed to have an equal total energy. Temporary (compound) and permanent threshold shifts were measured using evoked potentials. Sensory cell populations were evaluated with the surface preparation technique. The results obtained from each of the above paradigms were consistent in showing that the presence of vibration did not have a statistically significant effect on hearing thresholds. A parallel set of experiments using a 20 Hz; 2-g-rms vibration is in progress. Preliminary conclusions are essentially the same as those of the 30-Hz experiments. The suitability of the chinchilla as an animal model for use in vibration experiments will also be discussed. [Work supported by NIOSH.]
Recent Progress in AlGaN‐Based Deep‐UV LEDs (2015)

SUMMARY Deep‐ultraviolet (DUV) light‐emitting diodes (LEDs) are in demand for a wide variety of potential applications, such as sterilization, water and air purification, medical uses, and so on. We have demonstrated 222–351 nm AlGaN and quaternary InAlGaN‐based DUV‐LEDs by developing a low threading dislocation density (TDD) AlN crystal. We achieved an external quantum efficiency (EQE) of about 4% and an output power greater than 30 mW in DUV‐LEDs for use in sterilization applications by developing new crystal growth techniques.
Game theoretic models for resource sharing in wireless networks (2011)

Wireless communications have been recently characterized by rapid proliferation of wireless networks, impressive growth of standard and technologies, evolution of the end-user terminals, and increasing demand in the wireless spectrum. New, more flexible schemes for the management of the available resources, from both the user and the network side, are necessary in order to improve the efficiency in the usage of the available resources. This work aims at shedding light on the performance modeling of radio resource sharing/allocation situations. Since, in general, the quality of service perceived by a system (e.g., user, network) strictly depends on the behavior of the other entities, and the involved interactions are mainly competitive, this work introduces a framework based on non-cooperative game theoretic tools. Furthermore, non-cooperative game theory is suitable in distributed networks, where control and management are inherently decentralized. First, we consider the case in which many users have to make decisions on which wireless access point to connect to. In this scenario, the quality perceived by the users mainly depends on the number of other users choosing the very same accessing opportunity. In this context, we also consider two-stage games where network make decisions on how to use the available resources, and users react to this selecting the network that maximizes their satisfaction. Then, we refer to the problem of spectrum sharing, where users directly compete for portions of the available spectrum. Finally, we provide a more complex model where the users utility function is based on the Shannon rate. The aim of this second part is to provide a better representation of the satisfaction perceived by the users, i.e., in terms of achievable throughput. Due to the complexity of the game model, we first provide a complete analytical analysis of the two-user case. Then, we extend the model to the N-user case. We mainly analyze this game through simulations. Finally, inspired by the results obtained numerically, we introduce stochastic geometry in the analysis of spectrum games in order to predict the performance of the game in large networks.
Capacidad antioxidante total del suero en la diabetes mellitus (1996)

Con el objetivo de evaluar la presencia de estrés oxidativo en la diabetes mellitus se estudió en un grupo de 89 sujetos sanos y 104 pacientes diabéticos (50 tipo I y 54 tipo II) la variación de la capacidad antioxidante total del suero (TRAP) respecto al grado de control glicémico, evaluado por el valor de fructosamina sérica. Se encontró una disminución significativa de la capacidad TRAP en el grupo de pacientes pobremente controlados (fructosamina ³ 3,5 mmol/L) respecto a los controles y los pacientes satisfactoriamente controlados. De los parámetros antioxidativos del suero que contribuyen al valor TRAP, sólo el ácido úrico parece ser responsable de su disminución significativa en los pacientes pobremente controlados. Estos resultados brindan elementos sobre la presencia de estrés oxidativo en la diabetes y la posible utilización de una terapia antioxidativa nutricional en esta enfermedad.<br>With the aim of evaluating the presence of oxidative stress in diabetes mellitus, it was studied in a group of 89 healthy subjects and 104 diabetic patients (50, type I and 54, type II) the variation of total antioxidant capacity of serum (TRAP) in connection with the glicemic control degree, evaluated by the value of serum fructosamine. A marked reduction of TRAP capacity was found in the group of poorly controlled patients (fructosamine ³ 3,5 mol/L) as regards the controls and the successfully controlled patients. Of the antioxidative parameters of serum contributing to TRAP value, only the uric acid seems to be responsible of its signficant decrease among the poorly controlled patients. These results provide elements about the presence of oxidative stress in diabetes and about the possibility of using an antioxidative nutritional therapy in this disease.
Journal of translational medicine reviewer acknowledgement 2012 (2013)

The editor of Journal of Translational Medicine would like to thank all our reviewers who have contributed to the journal in Volume 10 (2012).
Transitions de phase structurales dans les fluorures ordonnes MIIZrF6(MII=Co,Zn) et dans l'incommensurable Cs2CdBr4 (1989)

Les etudes structurales et dynamiques des fluorures ordonnes m#i#izrf#6 (m#i#i=co,zn) ont permis d'etablir un modele phenomenologique, incluanbt des couplages entre la rotation des octaedres et leur deformation et la deformation de la maille (cisaillement), qui permet d'expliquer les effets observes. L'incommensurable cs#2cdbr#4 a ete etudie par diffusion raman et spectroscopie ultrasonique. Un modele phenomenologique faisant intervenir les mouvements de rotation des tetraedres cdbr#4 et de translation des cesium permet d'expliquer la succession des phases ferroelastiques observees (ninccomiv) avec en particulier l'accrochage (lock-in) s'effectuant en centre de zone de brillouin (inccom)
CCDC 812664: Experimental Crystal Structure Determination (2011)

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Autonomous Spot: Long-Range Autonomous Exploration of Extreme Environments with Legged Locomotion (2020)

This paper serves as one of the first efforts to enable large-scale and long-duration autonomy using the Boston Dynamics Spot robot. Motivated by exploring extreme environments, particularly those involved in the DARPA Subterranean Challenge, this paper pushes the boundaries of the state-of-practice in enabling legged robotic systems to accomplish real-world complex missions in relevant scenarios. In particular, we discuss the behaviors and capabilities which emerge from the integration of the autonomy architecture NeBula (Networked Belief-aware Perceptual Autonomy) with next-generation mobility systems. We will discuss the hardware and software challenges, and solutions in mobility, perception, autonomy, and very briefly, wireless networking, as well as lessons learned and future directions. We demonstrate the performance of the proposed solutions on physical systems in real-world scenarios. <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> The proposed solution contributed to winning 1st-place in the 2020 DARPA Subterranean Challenge, Urban Circuit. <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sup>
Isoflurane Mimics Ischemic Preconditioning via Activation of KATPChannels (1997)

Isoflurane directly preconditions myocardium against infarction via activation of K(ATP) channels in the absence of hemodynamic effects and exhibits acute memory of preconditioning in vivo.
?The Degradation of Deposition Blocking Layer during Area Selective Plasma Enhanced Atomic Layer Deposition of Cobalt (2010)

The effects of plasma on the degradation of the deposition blocking layer during area-selective atomic layer deposition were investigated. Co atomic layer deposition (ALD) processes were developed by using Co(iPr-AMD)(2) (bis (N,N'-diisopropylacetamidinato)cobalt(II)) as a precursor, and two different reactants, NH3 gas for thermal ALD (TH-ALD) and NH3 plasma for plasma-enhanced ALD (PE-ALD). TH- and PE-ALD were applied to area selective ALD (AS-ALD) by using an octadecyltrichlorosilane (OTS) self-assembled monolayer (SAM) as a blocking layer. Both ALD processes produced pure Go films with resistivities as low as 50 mu Omega cm. For PE-ALD, however, no selective deposition was achieved due to a degradation of the OTS hydrophobicity caused by the NH3 plasma exposure. The effects of the plasma on the blocking efficiency of SAM were studied.
Artificial Intelligence: Achievements and Promises* (2019)

In this chapter, the author attempts to give an overview of the field's goals, the techniques and methodologies which have evolved the field's existence, and some achievements to-date. Its existence Artificial Intelligence (AI) has pursued in parallel, several research goals; these can be summarised as: Building intelligent machines; Encoding in machine-manipulatable form human expertise; understanding human cognition. The first set of tasks have been approached by formulating mathematical models; the second set have been approached by AI which to-date has been concerned with symbolic models. Strange as it may seem search, systematic search, is one of AI's major techniques. AI has developed most fully deduction. Learning has been seen from the beginning of AI as a critical capability; if machines could not learn then AI's credibility would be questioned and moreover, its value as a technology would be greatly limited.