gebhart/patrepeval huggingface dataset:
Application of PSO for Optimization of Power Systems under Uncertainty (2010)

The primary objective of this dissertation is to develop a black box optimization tool. The algorithm should be able to solve complex nonlinear, multimodal, discontinuous and mixed-integer power system optimization problems without any model reduction. Although there are many computational intelligence (CI) based algorithms which can handle these problems, they require intense human intervention in the form of parameter tuning, selection of a suitable algorithm for a given problem etc. The idea here is to develop an algorithm that works relatively well on a variety of problems with minimum human effort. An adaptive particle swarm optimization algorithm (PSO) is presented in this thesis. The algorithm has special features like adaptive swarm size, parameter free update strategies, progressive neighbourhood topologies, self learning parameter free penalty approach etc. The most significant optimization task in the power system operation is the scheduling of various generation resources (Unit Commitment, UC). The current practice used in UC modelling is the binary approach. This modelling results in a high dimension problem. This in turn leads to increased computational effort and decreased efficiency of the algorithm. A duty cycle based modelling proposed in this thesis results in 80 percent reduction in the problem dimension. The stern uptime and downtime requirements are also included in the modelling. Therefore, the search process mostly starts in a feasible solution space. From the investigations on a benchmark problem, it was found that the new modelling results in high quality solutions along with improved convergence. The final focus of this thesis is to investigate the impact of unpredictable nature of demand and renewable generation on the power system operation. These quantities should be treated as a stochastic processes evolving over time. A new PSO based uncertainty modelling technique is used to abolish the restrictions imposed by the conventional modelling algorithms. The stochastic models are able to incorporate the information regarding the uncertainties and generate day ahead UC schedule that are optimal to not just the forecasted scenario for the demand and renewable generation in feed but also to all possible set of scenarios. These models will assist the operator to plan the operation of the power system considering the stochastic nature of the uncertainties. The power system can therefore optimally handle huge penetration of renewable generation to provide economic operation maintaining the same reliability as it was before the introduction of uncertainty.
[VO(H2O)5]H[PMo12O40]‐Catalyzed Nitration of Alkanes with Nitric Acid. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
[A case of pulmonary actinomycosis mimicking chronic necrotizing pulmonary aspergillosis]. (2010)

A 60-year-old man was admitted to our hospital with fever, appetite loss, and fatigue. Chest X-ray films and computed tomography scans showed fungus-ball-like lesions in the thoracic cavity, and pleural thickening with surrounding infiltration in the left upper lobe, developing over several months. The white blood cell count (WBC) and serum C-reactive protein (CRP) levels of the patient at the time of admission were 8800/microl and 2.7 mg/dl, respectively. He showed a negative reaction for the serum Aspergillus precipitating antibody, and a positive reaction for the serum Aspergillus antigen (Pletelia Aspergillus) according to the new cut-off index (the result was 0.8). From these clinical findings, we diagnosed this lesion as chronic necrotizing pulmonary aspergillosis (CNPA) and administered anti-fungal drugs (itraconazole plus micafungin, voriconazole) for several months. Despite medication, his condition appeared to deteriorate, and Aspergillus was never confirmed from frequent sputum cultures and bronchial lavage specimens. Finally, a pneumectomy was performed. Histopathological findings revealed a Gram-positive, filament-form Actinomyces cluster inside the cavity, which we diagnosed pulmonary actinomycosis. In this case, there was a possibility that the serum aspergillus antigen showed a false-positive reaction. Case must be taken in the evaluation of serum Aspergillus antigen testing.
Allene in molekularen Materialien (2012)

Abstract Dieser Kurzaufsatz liefert eine kritische Übersicht über die Entwicklung allenhaltiger fortschrittlicher Funktionsmaterialien. Ausgehend von Entwurf und Synthese stabiler, enantiomerenreiner Bausteine wird eine Vielfalt von Systemen – wie formstabile Makrocyclen, Foldamere, Polymere, Charge‐Transfer‐Chromophore, Dendrimere, Flüssigkristalle und redoxschaltbare chirale Chromophore – bezüglich ihrer Herstellung, Eigenschaften und möglichen Anwendungen diskutiert. Ziel der Zusammenstellung ist es, einen Anreiz zur verstärkten Anwendung enantiomerenreiner Allene beim rationalen Entwurf neuer Funktionswerkstoffe zu liefern.
Virtual Home Environments to Be Negotiated by a Multi‐Agent System (2001)

Chapter nine proposes a multi-agent system for implementing a Virtual Home Environment (VHE) using an Intelligent Network trigger. From the user's perspective the VHE scenario enables consistent, transparent access to subscription-based services when roaming. The system proposed uses third generation mobile phone technology, Universal Mobile Telecommunication System (UMTS), which is a service-driven standard aiming to build on and extend the capability of today's mobile technologies. Using the multi-agent framework with the new technology will enable network operators and service providers to increase their differentiation through rapid development value-added services.
BDA-SketRet: Bi-Level Domain Adaptation for Zero-Shot SBIR (2022)

The efficacy of zero-shot sketch-based image retrieval (ZS-SBIR) models is governed by two challenges. The immense distributions-gap between the sketches and the images requires a proper domain alignment. Moreover, the fine-grained nature of the task and the high intra-class variance of many categories necessitates a class-wise discriminative mapping among the sketch, image, and the semantic spaces. Under this premise, we propose BDA-SketRet, a novel ZS-SBIR framework performing a bi-level domain adaptation for aligning the spatial and semantic features of the visual data pairs progressively. In order to highlight the shared features and reduce the effects of any sketch or image-specific artifacts, we propose a novel symmetric loss function based on the notion of information bottleneck for aligning the semantic features while a cross-entropy-based adversarial loss is introduced to align the spatial feature maps. Finally, our CNN-based model confirms the discriminativeness of the shared latent space through a novel topology-preserving semantic projection network. Experimental results on the extended Sketchy, TU-Berlin, and QuickDraw datasets exhibit sharp improvements over the literature.
Single-cell transcriptomics of East-Asian pancreatic islets cells (2017)

Single-cell RNA-seq (scRNA-seq) of pancreatic islets have reported on α- and β-cell gene expression in mice and subjects of predominantly European ancestry. We aimed to assess these findings in East-Asian islet-cells. 448 islet-cells were captured from three East-Asian non-diabetic subjects for scRNA-seq. Hierarchical clustering using pancreatic cell lineage genes was used to assign cells into cell-types. Differentially expressed transcripts between α- and β-cells were detected using ANOVA and in silico replications of mouse and human islet cell genes were performed. We identified 118 α, 105 β, 6 δ endocrine cells and 47 exocrine cells. Besides INS and GCG, 26 genes showed differential expression between α- and β-cells. 10 genes showed concordant expression as reported in rodents, while FAM46A was significantly discordant. Comparing our East-Asian data with data from primarily European subjects, we replicated several genes implicated in nuclear receptor activations, acute phase response pathway, glutaryl-CoA/tryptophan degradations and EIF2/AMPK/mTOR signaling. Additionally, we identified protein ubiquitination to be associated among East-Asian β-cells. We report on East-Asian α- and β-cell gene signatures and substantiate several genes/pathways. We identify expression signatures in East-Asian β-cells that perhaps reflects increased susceptibility to cell-death and warrants future validations to fully appreciate their role in East-Asian diabetes pathogenesis.
Stacks off tracks: A role for the golgin AtCASP in plant endoplasmic reticulum – Golgi apparatus tethering (2017)

Abstract The plant Golgi apparatus modifies and sorts incoming proteins from the endoplasmic reticulum (ER), and synthesises cell wall matrix material. Plant cells possess numerous motile Golgi bodies, which are connected to the ER by yet to be identified tethering factors. Previous studies indicated a role of cis-Golgi plant golgins (long coiled-coil domains proteins anchored to Golgi membranes) in Golgi biogenesis. Here we show a tethering role for the golgin AtCASP at the ER-Golgi interface. Using live-cell imaging, Golgi body dynamics were compared in Arabidopsis thaliana leaf epidermal cells expressing fluorescently tagged AtCASP, a truncated AtCASP-ΔCC lacking the coiled-coil domains, and the Golgi marker STtmd. Golgi body speed and displacement were significantly reduced in AtCASP-ΔCC lines. Using a dual-colour optical trapping system and a TIRF-tweezer system, individual Golgi bodies were captured in planta. Golgi bodies in AtCASP-ΔCC lines were easier to trap, and the ER-Golgi connection was more easily disrupted. Occasionally, the ER tubule followed a trapped Golgi body with a gap, indicating the presence of other tethering factors. Our work confirms that the intimate ER-Golgi association can be disrupted or weakened by expression of truncated AtCASP-ΔCC, and suggests that this connection is most likely maintained by a golgin-mediated tethering complex. Highlight Here we show that the Golgi-associated Arabidopsis thaliana protein AtCASP may form part of a golgin-mediated tethering complex involved in anchoring plant Golgi stacks to the endoplasmic reticulum (ER).
Decay of correlations in systems of fermions with long-range interactions at non-zero temperature (2017)

We study correlations in fermionic lattice systems with long-range interactions in thermal equilibrium. We prove a bound on the correlation decay between anti-commuting operators and generalize a long-range Lieb-Robinson type bound. Our results show that in these systems of spatial dimension $D$ with, not necessarily translation invariant, two-site interactions decaying algebraically with the distance with an exponent $\alpha \geq 2\,D$, correlations between such operators decay at least algebraically with an exponent arbitrarily close to $\alpha$ at any non-zero temperature. Our bound is asymptotically tight, which we demonstrate by a high temperature expansion and by numerically analyzing density-density correlations in the 1D quadratic (free, exactly solvable) Kitaev chain with long-range pairing.
Measurement of molten chocolate friction under simulated tongue-palate kinematics: Effect of cocoa solids content and aeration (2020)

The perception of some food attributes is related to mechanical stimulation and friction experienced in the tongue-palate contact during mastication. This paper reports a new bench test to measure friction in the simulated tongue-palate contact. The test consists of a flat PDMS disk, representing the tongue loaded and reciprocating against a stationary lower glass surface representing the palate. The test was applied to molten chocolate samples with and without artificial saliva. Friction was measured over the first few rubbing cycles, simulating mechanical degradation of chocolate in the tongue-palate region. The effects of chocolate composition (cocoa solids content ranging between 28 ​wt% and 85 ​wt%) and structure (micro-aeration/non-aeration 0-15 ​vol%) were studied. The bench test clearly differentiates between the various chocolate samples. The coefficient of friction increases with cocoa solids percentage and decreases with increasing micro-aeration level. The presence of artificial saliva in the contact reduced the friction for all chocolate samples, however the relative ranking remained the same.
Dynamic Interfacial Reaction Rates from Electrochemistry–Mass Spectrometry (2021)

Electrochemistry-mass spectrometry is a versatile and reliable tool to study the interfacial reaction rates of Faradaic processes with high temporal resolutions. However, the measured mass spectrometric signals typically do not directly correspond to the partial current density toward the analyte due to mass transport effects. Here, we introduce a mathematical framework, grounded on a mass transport model, to obtain a quantitative and truly dynamic partial current density from a measured mass spectrometer signal by means of deconvolution. Furthermore, it is shown that the time resolution of electrochemistry-mass spectrometry is limited by entropy-driven processes during mass transport to the mass spectrometer. The methodology is validated by comparing the measured impulse responses of hydrogen and oxygen evolution to the model predictions and subsequently applied to uncover dynamic phenomena during hydrogen and oxygen evolution in an acidic electrolyte.
iVQA: Inverse Visual Question Answering (2018)

We propose the inverse problem of Visual question answering (iVQA), and explore its suitability as a benchmark for visuo-linguistic understanding. The iVQA task is to generate a question that corresponds to a given image and answer pair. Since the answers are less informative than the questions, and the questions have less learnable bias, an iVQA model needs to better understand the image to be successful than a VQA model. We pose question generation as a multi-modal dynamic inference process and propose an iVQA model that can gradually adjust its focus of attention guided by both a partially generated question and the answer. For evaluation, apart from existing linguistic metrics, we propose a new ranking metric. This metric compares the ground truth question's rank among a list of distractors, which allows the drawbacks of different algorithms and sources of error to be studied. Experimental results show that our model can generate diverse, grammatically correct and content correlated questions that match the given answer.
Development and Evaluation of Collaborative Embedded Systems using Simulation (2020)

Abstract Embedded systems are increasingly equipped with open interfaces that enable communication and collaboration with other embedded systems, thus forming collaborative embedded systems (CESs). This new class of embedded systems, capable of collaborating with each other, is planned at design time and forms collaborative system groups (CSGs) at runtime. When they are part of a collaboration, systems can negotiate tactical goals, with the aim of achieving higher level strategic goals that cannot be achieved otherwise. The design and operation of CESs face specific challenges, such as operation in an open context that dynamically changes in ways that cannot be predicted at design time, collaborations with systems that dynamically change their behavior during runtime, and much more. In this new perspective, simulation techniques are crucially important to support testing and evaluation in unknown environments. In this chapter, we present a set of challenges that the design, testing, and operation of CESs face, and we provide an overview of simulation methods that address those specific challenges.
A phase II study with gemcitabine and split-dose cisplatin in patients with advanced non-small cell lung cancer (2006)

17115 Background: The combination of gemcitabine and cisplatin is among the most active regimens for the treatment of NSCLC. However, the optimal dose and schedule for administration of the two drugs has not yet been determined. We investigated the activity and toxicity of a gemcitabine and split-dose cisplatin regimen in an outpatient setting for patients with advanced non-small cell lung cancer (NSCLC). Methods: From June 2004 to May 2005 patients with stage IIIB or IV who had not had prior chemotherapy entered the study. Treatment consisted of gemcitabine 1,250 mg/m 2 and cisplatin 35 mg/m 2 , both given intravenously on days 1 and 8 every 21 days. Results: Forty-three patients were entered this study. Patient characteristics were as follows: male/female, 32/11; median age (range), 63 (30–76) years; ECOG PS 0/1/2, 7/28/8; stage IIIB/IV, 17/26. A total of 160 cycles were delivered, with a median of 4 cycles (range, 1–6). All patients were evaluable for toxicity. Grade 3 &amp; 4 toxicities according the NCI toxicity criteria included included neutropenia in 7 patients (17%), anemia in 3 (7%), thrombocytopenia in 6 (14%), and emesis in 1 (2%). Of 40 patients assessable for response, one (2.5%) had CR and 22 (55%) had PR. On intent-to-treat basis, the overall response rate was 53% (95% CI, 39–68%). Median time to progression was 6.0 months (range, 1.2–12.0 months) and median overall survival was 13.1 months (range, 1.4–17 months). Conclusions: This regimen with gemcitabine and split-dose cisplatin using a 21-day schedule appears to be active and very well-tolerated in an outpatients setting for patients with advanced NSCLC. No significant financial relationships to disclose.
IL-8 causes in vivo neutrophil migration by a cell-dependent mechanism. (1991)

A dose-dependent neutrophil migration was observed following the injection of recombinant interleukin-8 (rIL-8) into rat peritoneal cavities. This finding contrasts with the inability of rIL-8 to induce neutrophil emigration into subcutaneous air-pouches. Pre-treatment of the animals with dexamethasone (0.5 mg/kg, s.c.) or depletion of the peritoneal resident cell population abolished the neutrophil migration induced by rIL-8 and by recombinant interleukin-1 beta (rIL-1 beta). Different from that which occurs with rIL-1 beta, neutrophil migration induced by rIL-8 was not enhanced by an increase in the peritoneal macrophage population. Transference of homologous total resident peritoneal cells to the air-pouch rendered this cavity responsive to the chemotactic effect of rIL-8 and potentiated the neutrophil migration induced by rIL-1. Our results show that both rIL-8 and rIL-1 beta are able to induce in vivo neutrophil migration by an indirect mechanism, dependent on resident cells. Neither macrophages nor lymphocytes seem to be involved in the rIL-8 chemotactic effect. However, peritoneal resident mast cells may be implicated in this mechanism. These cells, when stimulated in vitro by rIL-8, released a factor that when injected into peritoneal and air-pouch cavities induced neutrophil migration.
HMGB1: A Promising Therapeutic Target for Prostate Cancer (2013)

High mobility group box 1 (HMGB1) was originally discovered as a chromatin-binding protein several decades ago. It is now increasingly evident that HMGB1 plays a major role in several disease conditions such as atherosclerosis, diabetes, arthritis, sepsis, and cancer. It is intriguing how deregulation of HMGB1 can result in a myriad of disease conditions. Interestingly, HMGB1 is involved in cell proliferation, angiogenesis, and metastasis during cancer progression. Furthermore, HMGB1 has been demonstrated to exert intracellular and extracellular functions, activating key oncogenic signaling pathways. This paper focuses on the role of HMGB1 in prostate cancer development and highlights the potential of HMGB1 to serve as a key target for prostate cancer treatment.
Amorphous metal foil for brazing copper electrical joints (1985)

Brazing of copper electrical conductors is of importance in power transformers, and uses a great amount of brazing material. The areas brazed are usually inside the coil, and consist of taps, leads, and splices. Since the brazing is done inside the coil care must be taken in the making of the joint to prevent insulation damage and annealing of the joint area due to the brazing temperatures. A new brazing foil with a lower melting temperature than the currently used AWS BCuP-5 [1] braze is on the market. This foil has an amorphous structure with a copper base, 7% phosphorous, and no silver. Due to its lower melting temperature there is less heat input in the base material during brazing, therefore, there is less likelihood of insulation damage, less annealing of the joint area, lower oxide buildup, and less time to effect a joint.
Cholesteryl oleate-loaded cationic solid lipid nanoparticles as carriers for efficient gene-silencing therapy (2018)

The results indicate that cholesteryl oleate-loaded SLNs are a safe and effective platform for nonviral nucleic acid delivery.
Out of the Frying Pan Into the Fire (2017)

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Single-cell multi-omic analysis of the vestibular schwannoma ecosystem uncovers a nerve injury-like state (2022)

ABSTRACT Vestibular schwannomas (VS) are benign tumors that lead to significant neurologic and otologic morbidity. How VS heterogeneity and the tumor microenvironment (TME) contribute to the pathogenesis of these tumors remains poorly understood. We performed scRNA-seq on 15 VS samples, with paired scATAC-seq in six samples. We identified diverse Schwann cell (SC), stromal, and immune populations in the VS TME and found that repair-like and MHC-II antigen presenting subtype SCs are associated with increased myeloid cell infiltrate, implicating a nerve injury-like process. Deconvolution analysis of RNA-expression data from 175 tumors revealed Injury-like tumors are associated with larger tumor size, and scATAC-seq identified transcription factors associated with nerve repair among SCs from Injury-like tumors. Ligand-receptor analysis and functional in vitro experiments suggested that SCs recruit monocytes. Our study indicates that Injury-like SCs may cause tumor growth via myeloid cell recruitment and identifies molecular pathways that may be targeted to prevent tumor progression.
Simultaneous Voltage and Heat Transfer distribution Measurements on an Arc Plasma Wind Tunnel Constrictor (2020)

Experiments were conducted to simultaneously quantify the voltage distribution and heat losses along the length of an arc plasma wind tunnel constrictor employing air and argon gas. The objective was to generate a detailed data set and make it available electronically to the scientific community. High spatial resolution voltage measurements allowed us to identify a wave-like structure in the upstream part of the constrictor. Although no clear explanation was found, it was postulated that electrode erosion produced an unstable arc geometry that was further distorted by the imposed magnetic fields. Alternatively, the wave-like structure could be related to vortex precession commonly observed in swirl-stabilized flows. Measurements of heat transfer to the wall, based on differences in cooling water temperature across each segment, revealed a mainly uniform heat-transfer distribution along the constrictor, with elevated heat transfer near the cathode and anode due to the strong electric field strengths in the near-cathode and near-anode regions. By varying either mass flowrate or current, these measurements also allowed us, for the first time, to estimate differences in radiation and convection heat transfer.