gebhart/patrepeval huggingface dataset:
Metallic-like Stoichiometric Copper Sulfide Nanocrystals: Phase- and Shape-Selective Synthesis, Near-Infrared Surface Plasmon Resonance Properties, and Their Modeling (2013)

In the realm of semiconductor nanomaterials, a crystal lattice heavily doped with cation/anion vacancies or ionized atomic impurities is considered to be a general prerequisite to accommodating excess free carriers that can support localized surface plasmon resonance (LSPR). Here, we demonstrate a surfactant-assisted nonaqueous route to anisotropic copper sulfide nanocrystals, selectively trapped in the covellite phase, which can exhibit intense, size-tunable LSPR at near-infrared wavelengths despite their stoichiometric, undoped structure. Experimental extinction spectra are satisfactorily reproduced by theoretical calculations performed by the discrete dipole approximation method within the framework of the Drude-Sommerfeld model. The LSPR response of the nanocrystals and its geometry dependence are interpreted as arising from the inherent metallic-like character of covellite, allowed by a significant density of lattice-constitutional valence-band free holes. As a consequence of the unique electronic properties of the nanocrystals and of their monodispersity, coherent excitation of symmetric radial breathing modes is observed for the first time in transient absorption experiments at LSPR wavelengths.
Autoantibody screening in Guillain-Barré Syndrome (2021)

A bstract Guillain-Barré Syndrome (GBS) is an acute inflammatory neuropathy with a heterogeneous presentation and pathogenesis. Serum antibodies against various gangliosides can be found in less than half of all patients in the acute phase of GBS but the target antigens remain unknown for the remaining half. Our work describes a comprehensive screening for serum autoantibodies targeting peripheral nerve tissue, cells, and purified antigens in a prospective GBS cohort including 100 patients. Our study confirms that (1) GBS patients display a very heterogeneous repertoire of autoantibodies targeting nerve cells and structures, (2) gangliosides are the most frequent antigens in GBS patients and have prognostic value, (3) a small subset of patients display antibodies targeting the myelin sheath, and (4) further antigen-discovery experiments are needed to elucidate other potential disease-specific autoantibodies in GBS.
Complementary Strand Association between Nucleic Acids and Nucleic Acid Gels (1963)

Nucleic acid gels can be formed as a result of the cross-linking action of ultraviolet light or of nitrous acid. Such gels form duplex combinations with complementary nucleic acid strands.
The Mechanism behind Bacterial Lipoprotein Release: Phenol-Soluble Modulins Mediate Toll-Like Receptor 2 Activation via Extracellular Vesicle Release from Staphylococcus aureus (2018)

The innate immune system uses Toll-like receptor (TLR) 2 to detect conserved bacterial lipoproteins of invading pathogens. The lipid anchor attaches lipoproteins to the cytoplasmic membrane and prevents their release from the bacterial cell envelope. How bacteria release lipoproteins and how these molecules reach TLR2 remain unknown. <i>Staphylococcus aureus</i> has been described to liberate membrane vesicles. The composition, mode of release, and relevance for microbe-host interaction of such membrane vesicles have remained ambiguous. We recently reported that <i>S. aureus</i> can release lipoproteins only when surfactant-like small peptides, the phenol-soluble modulins (PSMs), are expressed. Here we demonstrate that PSM peptides promote the release of membrane vesicles from the cytoplasmic membrane of <i>S. aureus</i> via an increase in membrane fluidity, and we provide evidence that the bacterial turgor is the driving force for vesicle budding under hypotonic osmotic conditions. Intriguingly, the majority of lipoproteins are released by <i>S. aureus</i> as components of membrane vesicles, and this process depends on surfactant-like molecules such as PSMs. Vesicle disruption at high detergent concentrations promotes the capacity of lipoproteins to activate TLR2. These results reveal that vesicle release by bacterium-derived surfactants is required for TLR2-mediated inflammation.<b>IMPORTANCE</b> Our study highlights the roles of surfactant-like molecules in bacterial inflammation with important implications for the prevention and therapy of inflammatory disorders. It describes a potential pathway for the transfer of hydrophobic bacterial lipoproteins, the major TLR2 agonists, from the cytoplasmic membrane of Gram-positive bacteria to the TLR2 receptor at the surface of host cells. Moreover, our study reveals a molecular mechanism that explains how cytoplasmic and membrane-embedded bacterial proteins can be released by bacterial cells without using any of the typical protein secretion routes, thereby contributing to our understanding of the processes used by bacteria to communicate with host organisms and the environment.
Evaluation of habitat quality and ecological flow in a regulated waterway (2022)

Abstract Dam control changes the hydraulic environment and hydrological rhythm of rivers; to explore the causes of fish habitat loss and influence of river regulation in such rivers, the downstream curving reaches of Shaying River were cut off. Grass, silver, and bighead carp were selected as the research targets, and the impact of waterway regulation and the effect of gravel mounds on the target fish habitat were studied using numerical simulation. The results show that the original channel's hydraulic environment is similar to the artificial channel, and the target fish spawning habitat is limited, which is an important reason for the shortage of fish resources in the research area. The reconstructed channel can meet the river's navigation demands and improve the channel's flood discharge capacity. The habitat method was used to estimate the minimum and appropriate ecological flows of the target fish at each growth stage in the original and reconstructed rivers. Under the appropriate ecological flow, the weighted usable area (WUA) of juvenile, migratory, and spawning habitats of the target fish in the reconstructed river increased by 168, 24, and 580%, respectively, compared to the original channel, while the WUA of adult fish that preferred a slow-water environment decreased by 62%, effectively improving the target fish's spawning environment.
Selective Detection of Hydrogen with Surface Acoustic Wave Devices Using Palladium Layer Properties (2013)

For an increasing number of applications, hydrogen represents a solution of the future as it is the most common element in the Earth. However, due to its unstable properties in gas phase, a particular care must be dedicated to control possible gaseous leaks close to tanks and facilities using this resource. In this paper, surface acoustic wave sensors are proposed for detecting gaseous hydrogen in standard environmental conditions (atmospheric pressure and room temperature). The proposed Surface Acoustic Wave sensors consists in two Rayleigh-wave delay lines built on Quartz, one equipped with a palladium overlay and the other exhibiting a free path between the two interdigited transducers. A specific gas test cell has been developed to test various sensor configurations submitted to hydrogen-composed atmospheres. A particular care was paid to avoid hydrogen leakage in the working environment and to perform the regeneration of the gas absorbing layer. The developed device allows for identifying different concentrations of hydrogen (in the 1-4 % range) diluted in nitrogen and is also able to detect hydrogen in current atmosphere. Surface Acoustic Wave devices exploiting hydrogen absorption capabilities of palladium thin films have been here used to make the detection and the identification of hydrogen concentrations in the 1-4 % range and the influence of outer parameters such as temperature and relative humidity variations on the sensor operation are also reported.
Thread scheduling for multiprogrammed multiprocessors (1998)

We present a user-level thread scheduler for shared-memory multiprocessors, and we analyze its performance under multiprogramming. We model multiprogramming with two scheduling levels: our scheduler runs at user-level and schedules threads onto a fixed collection of processes, while below this level, the operating system kernel schedules processes onto a fixed collection of processors. We consider the kernel to be an adversary, and our goal is to schedule threads onto processes such that we make efficient use of whatever processor resources are provided by the kernel. Our thread scheduler is a non-blocking implementation of the work-stealing algorithm. For any multithreaded computation with work T1 and critical-path length T∈fty , and for any number P of processes, our scheduler executes the computation in expected time O(T1/PA + T∈fty P/PA) , where PA is the average number of processors allocated to the computation by the kernel. This time bound is optimal to within a constant factor, and achieves linear speedup whenever P is small relative to the parallelism T1/T∈fty .
A Focus on Antiarrhythmic Properties of Ranolazine (2012)

Ranolazine is an antianginal drug that inhibits a number of ion currents that are important for the genesis of transmembrane cardiac action potential. It was initially developed as an antianginal agent but was found to additionally exert antiarrhythmic actions, due to its multichannel-blocking properties. In recent years, several studies about the antiarrhythmic properties of ranolazine were conducted, demonstrating the beneficial effects of this drug in both atrial and ventricular arrhythmias, such as atrial fibrillation, ventricular premature beats, ventricular tachycardia, torsades de pointes, and ventricular fibrillation. Our aim is to briefly review the main points of these studies, most more experimental than clinical.
Demonstration of Mueller polarimetry through an optical fiber for endoscopic applications (2014)

International audience
Porcine Model of Spinal Cord Injury: A Systematic Review (2022)

Spinal cord injury (SCI) is a devastating disease with limited effective treatment options. Animal paradigms are vital for understanding the pathogenesis of SCI and testing potential therapeutics. The porcine model of SCI is increasingly favored because of its greater similarity to humans. However, its adoption is limited by the complexities of care and range of testing parameters. Researchers need to consider swine selection, injury method, post-operative care, rehabilitation, behavioral outcomes, and histology metrics. Therefore, we systematically reviewed full-text English-language articles to evaluate study characteristics used in developing a porcine model and summarize the interventions that have been tested using this paradigm. A total of 63 studies were included, with 33 examining SCI pathogenesis and 30 testing interventions. Studies had an average sample size of 15 pigs with an average weight of 26 kg, and most used female swine with injury to the thoracic cord. Injury was most commonly induced by weight drop with compression. The porcine model is amenable to testing various interventions, including mean arterial pressure augmentation (<i>n</i> = 7), electrical stimulation (<i>n</i> = 6), stem cell therapy (<i>n</i> = 5), hypothermia (<i>n</i> = 2), biomaterials (<i>n</i> = 2), gene therapy (<i>n</i> = 2), steroids (<i>n</i> = 1), and nanoparticles (<i>n</i> = 1). It is also notable for its clinical translatability and is emerging as a valuable pre-clinical study tool. This systematic review can serve as a guideline for researchers implementing and testing the porcine SCI model.
Understanding Cloud Computing: Experimentation and Capacity Planning (2009)

Cloud computing is based on the notion of shared computational, storage, network, and application resources provided by a third party. This paper explores in detail the concept of cloud computing, its advantages and disadvantages and describes several existing cloud computing platforms. It then discusses the results of quantitative experiments carried out using PlanetLab, a cloud computing platform. The paper also discusses how the methods of capacity planning are impacted by the advent of cloud computing from the point of view of the cloud user and from the cloud provider. 1
2D Cascaded AdaBoost for Eye Localization (2006)

In this paper, 2D cascaded AdaBoost, a novel classifier designing framework, is presented and applied to eye localization. By the term “2D”, we mean that in our method there are two cascade classifiers in two directions: The first one is a cascade designed by bootstrapping the positive samples, and the second one, as the component classifiers of the first one, is cascaded by bootstrapping the negative samples (please refer to Fig.1). The advantages of the 2D structure include: (1) It greatly facilitates the classifier designing on huge-scale training set; (2) It can easily deal with the significant variations within the positive (or negative) samples; (3) Both the training and testing procedures are more efficient. The proposed structure is applied to eye localization and evaluated on four public face databases, extensive experimental results verified the effectiveness, efficiency, and robustness of the proposed method.
Pyrazine Diuretics. II. N-Amidino-3-amino-5-substituted 6-Halopyrazinecarboxamides (1967)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPyrazine Diuretics. II. N-Amidino-3-amino-5-substituted 6-HalopyrazinecarboxamidesEdward J. Cragoe, Otto W. Woltersdorf, John B. Bicking, Sara F. Kwong, and James H. JonesCite this: J. Med. Chem. 1967, 10, 1, 66–75Publication Date (Print):January 1, 1967Publication History Published online1 May 2002Published inissue 1 January 1967https://pubs.acs.org/doi/10.1021/jm00313a014https://doi.org/10.1021/jm00313a014research-articleACS PublicationsRequest reuse permissionsArticle Views947Altmetric-Citations260LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Advanced Photonics: keeping up with the community (2021)

<i>Advanced Photonics</i>, co-published by SPIE and Chinese Laser Press, is a highly selective, gold open access, international journal publishing innovative research in all areas of optics and photonics, including fundamental and applied research.
Modeling of conductive states in polymer nanocomposites with disordered GaAs nanowire array (2019)

Abstract We provide numerical Monte Carlo modeling of conductive properties of polymer composites, comprised by doping a polymer matrix with carbon nanotubes and III-IV GaAs nanowires. We apply the basic Su-Schrieffer-Heeger model, which is considered universal for every component of such ternary systems, and in a general case with required parameters. Such modeling of conductive characteristics is motivated by requirements of optimization of geometry and structure of novel photovoltaic devices.
Bi0.5Pb0.5FeO3 with Unusual Pb Charge Disproportionation: Indication of a Systematic Charge Distribution Change in Bi0.5Pb0.5MO3 (M: 3d Transition Metal) (2022)

Bi<sub>0.5</sub>Pb<sub>0.5</sub>FeO<sub>3</sub> with 1:1 mixture of Bi and Pb having charge degrees of freedom at the A-site of perovskite oxide ABO<sub>3</sub> is obtained for the first time by high-pressure synthesis. Comprehensive synchrotron X-ray powder diffraction, optical second harmonic generation, Mössbauer spectroscopy, and hard X-ray photoemission spectroscopy measurements revealed that Bi<sub>0.5</sub>Pb<sub>0.5</sub>FeO<sub>3</sub> is a canted antiferromagnetic insulator crystalizing in a nonpolar tetragonal <i>I</i>4/<i>mcm</i> structure with √2<i>a</i> × √2<i>a</i> × 2<i>a</i> unit cell and has unusually Pb charge disproportionated Bi<sup>3+</sup><sub>0.5</sub>Pb<sup>2+</sup><sub>0.25</sub>Pb<sup>4+</sup><sub>0.25</sub>Fe<sup>3+</sup>O<sub>3</sub> charge distribution. The valence of transition metal <i>M</i> in Bi<sub>0.5</sub>Pb<sub>0.5</sub><i>M</i>O<sub>3</sub> changes from 3.5+ to 3+ and finally to 2+ from Mn to Fe and to Ni, from left to right in the periodic table as the 3d-level becomes deeper. The valences of Bi and Pb increase to compensate for the decrease in the <i>M</i>'s valence, and Pb changes from 6s<sup>2</sup> (2+) to 6s<sup>0</sup> (4+) before Bi changes.
Evaluation of in vitro anti-inflammatory effects of the remaining water subextract of Cistus laurifolius leaves (2015)

Cistus laurifolius L. (Cistaceae) is known as 'laden' in Anatolia and the leaves of the plant are used against rheumatismal diseases traditionally [1]. The ethanol extract of the leaves were submitted to solvent-solvent extractions and n-hexane, chloroform, ethyl acetate, n-butanol, remaining water subextracts were obtained. The extract and subextracts were investigated for their inhibitory effects on Nuclear Factor kappa B (NF-κB) transcrption factor on lipopolysaccharide induced Raw 264.7 macrophages. Only remaining water subextract exerted 20% inhibition. The subextract was fractionated by chromatographic methods but the fractions were found to be not effective. Thus, remaining water subextract was directed for further in vitro anti-inflammatory investigations. The effects on nitric oxide (NO), prostaglandine E2 (PGE2), tumor necrosis factor (TNFα) and interleukins (IL-1α, IL-1β, IL-2, IL-6) were studied by Griess and ELISA. The effects on iNOS and COX-2 protein levels and the phosphorylation levels of mitogen activated protein kinases (ERK1/2, JNK, p38) and I kappa B alpha (IκBα) were examined by Western Blot method. The subextract was applied to Raw 264.7 macrophage cells at 25, 50 and 100 µg/mL concentrations and it provided up to 57% decrease of NO production and up to 55% decrease of PGE2 production of cells. The iNOS and COX-2 protein levels were decreased accordingly. The subextract exerted inhibitory effect on TNFα (37%). This subextract inhibited the phosphorylation of IκBα at 50 and 100 µg/mL concentrations while JNK phosphorylation was concentration-dependently inhibited.
Pharmacokinetics and Safety Profile of the Human Anti- Pseudomonas aeruginosa Serotype O11 Immunoglobulin M Monoclonal Antibody KBPA-101 in Healthy Volunteers (2009)

KBPA-101 is a human monoclonal antibody of the immunoglobulin M isotype, which is directed against the O-polysaccharide moiety of Pseudomonas aeruginosa serotype O11. This double-blind, dose escalation study evaluated the safety and pharmacokinetics of KBPA-101 in 32 healthy volunteers aged 19 to 46 years. Each subject received a single intravenous infusion of KBPA-101 at a dose of 0.1, 0.4, 1.2, or 4 mg/kg of body weight or placebo infused over 2 h. Plasma samples for pharmacokinetic assessments were taken before infusion as well as 0.25, 0.5, 1, 2, 2.5, 4, 6, 8, 12, 24, 36, and 48 h and 4, 7, 10, and 14 days after start of dosing. Plasma concentrations of KBPA-101 were detected with mean maximum concentrations of drug in plasma of 1,877, 7,571, 24,923, and 83,197 ng/ml following doses of 0.1, 0.4, 1.2, and 4.0 mg/kg body weight, respectively. The mean elimination half-life was between 70 and 95 h. The mean volume of distribution was between 4.76 and 5.47 liters. Clearance ranged between 0.039 and 0.120 liters/h. At the highest dose of 4.0 mg/kg, plasma KBPA-101 levels were greater than 5,000 ng/ml for 14 days. KBPA-101 exhibited linear kinetics across all doses. No anti-KBPA-101 antibodies were detected after dosing in any subject. Overall, the human monoclonal antibody KBPA-101 was well tolerated over the entire dose range in healthy volunteers, and no serious adverse events have been reported.
Enzymatic production of ribavirin from pyrimidine nucleosides by Enterobacter aerogenes AJ 11125. (1988)

Microorganisms that produce ribavirin(1-β-D-ribofuranosyl-1, 2, 4-triazole-3-carboxamide; virazole®) directly from pyrimidine nucleosides and TCA (1, 2, 4-triazole-3-carboxamide) were screened from our stock cultures. Of the 400 strains tested, 16 were isolated as ribavirin-producers from uridine or cytidine. In particular, Enterobacter aerogenes AJ 11125, Bacillus brevis AJ 1282 and Sarcina lutea AJ 1212 were found to possess potent activities of ribavirin production from them. In the presence of intact cells of Enterobacter aerogenes AJ 11125, which was selected as the best strain, 110.2mM and 67.6mM ribavirin were produced from uridine and cytidine, respectively, on 96 hr reaction at 60°C. In addition, this strain could also produce ribavirin from guanosine, but could not produce it from orotidine, which is also a pyrimidine nucleoside.
Strategies for Minimum Energy Operation for Precision Machining (2009)

The development of "green" machine tools will require novel approaches for design, production and operation for energy savings and reduced environmental impact. We describe here work on three projects: i. influence of process parameters on power consumption of end-milling using force and process time models with experimental verification. Process parameters are chosen to minimize process time since power consumed by a machine tool is essentially independent of the load and energy per unit manufactured decreases with process time; ii. KERS (kinetic energy recovery system) for machine design and modeling the integration of a recovery system into a machine tool to calculate the amount of energy that could be recovered, and whether the environmental benefits are significant; and iii. evaluation of interoperability solutions, such as MTConnect, as tools enabling a standardized "plug-and-play" platform to integrate sensors with a unified monitoring scheme to achieve improved energy performance.
Relationship between insulin resistance and left ventricular function in patients with essential hypertension (2002)

Both left ventricular hypertrophy and insulin resistance (IR) have often been demonstrated in patients with essential hypertension (EH). Insulin may exert a direct growth-promoting effect on cardiomyocytes. The purpose of this study was to examine the relationship between left ventricular function and IR in patients with EH. Ambulatory 24-hour blood pressure (BP) monitoring, transthoracic echocardiography, and blood samples were performed in 21 never-treated non-diabetic patients with EH (56±3 <SE> y: 9 men and 12 women). With respect to IR, homeostasis model assessment (HOMA) was calculated. HOMA-index = Fasting blood sugar (mg/dl) * Immunoreactive insulin (μU/ml) / 405. Each subject was also examined for mitral inflow velocity pattern and left ventricular outflow velocity pattern, and the Doppler-derived index (total ejection isovolume index : TEI index) of combined systolic and diastolic myocardial performance was calculated. TEI index was univariately related to HOMA-index (r=0.67, p<0.001), left ventricular mass index (r=0.52, p<0.05), body mass index (r=0.45, p<0.05), and night-time diastolic BP (r=0.43, p=0.05). By stepwise regression analysis, TEI index was significantly related to HOMA-index as an independent variable (R2=0.43, p<0.001). It was suggested that IR might be contributory to left ventricular dysfunction in patients with EH.