gebhart/patrepeval huggingface dataset:
Palladium Nanoparticles Immobilized on Chemically Modified Silica Gel: Efficient Heterogeneous Catalyst for Suzuki, Stille and Sonogashira Cross‐Coupling Reactions (2011)

Abstract Nanoparticulate palladium ( Pd np ‐2 ) supported on polyethylene glycol‐functionalized silica gel is an excellent heterogeneous catalytic system for Suzuki, Sonogashira and Stille cross‐coupling reactions that afford products in high yield. The immobilized palladium nanoparticles were readily prepared by reaction of modified silica gel ( 1 ) with potassium tetrachloropalladate(II) in the presence of an acyl metal salt of a Fischer carbene complex. The nanoparticles were characterized by X‐ray diffraction (XRD) and transmission electron microscopy (TEM). The catalyst ( Pd np ‐2 ) is thermally stable, insensitive to oxygen, and recyclable. The catalyst has been used for five cycles without noticeable loss of catalytic activity.
389: Eosinophilic Pulmonary Syndrome as a Manifestation of Pulmonary Graft-versus-host-disease Following Hematopoietic Stem Cell Transplantation in Three Patients (2008)

Eosinophilic pulmonary syndrome has been an uncommon problem in stem cell transplant recipients that can mimic an infectious process. We report the occurrence of three cases of eosinophilic pulmonary syndrome as a manifestation of pulmonary graft-versus-host-disease (GVHD) in the setting of allogeneic hematopoietic stem cell transplantation (HSCT), after day 100 post-transplant, for hematological disorders. All three patients had skin GVHD complicating their post-transplant course. All three patients had peripheral blood eosinophilia with their lung biopsies showing pronounced infiltrates of eosinophils involving bronchioles. Following the administration of high-dose systemic steroid therapy, all patients responded rapidly with improvement of their pulmonary symptoms and the resolution of peripheral blood eosinophilia. Clinicians should be aware that eosinophilic pulmonary syndrome can occur following HSCT and it can be associated with GVHD. Eosinophilic pulmonary syndrome has been an uncommon problem in stem cell transplant recipients that can mimic an infectious process. We report the occurrence of three cases of eosinophilic pulmonary syndrome as a manifestation of pulmonary graft-versus-host-disease (GVHD) in the setting of allogeneic hematopoietic stem cell transplantation (HSCT), after day 100 post-transplant, for hematological disorders. All three patients had skin GVHD complicating their post-transplant course. All three patients had peripheral blood eosinophilia with their lung biopsies showing pronounced infiltrates of eosinophils involving bronchioles. Following the administration of high-dose systemic steroid therapy, all patients responded rapidly with improvement of their pulmonary symptoms and the resolution of peripheral blood eosinophilia. Clinicians should be aware that eosinophilic pulmonary syndrome can occur following HSCT and it can be associated with GVHD.
Diversity and distribution of a deeply branched novel proteobacterial group found in anaerobic–aerobic activated sludge processes (2002)

A novel coccobacilli group found previously in enhanced biological phosphorus removal (EBPR) systems was further revealed to have a high degree of diversity and distribution in various activated sludge systems. Phylogenetic analysis based on 14 existing and 18 newly retrieved 16S rRNA sequences revealed that these sequences formed a novel cohesive cluster with seven subgroups in the gamma-Proteobacteria. Fluorescence in situ hybridization with a set of probes designed specifically targeting the novel group at different hierarchical levels showed that the novel group with a coccoid (2-4 micro m) to occasionally long-rod (up to 20 micro m) shape widely distributed and in some cases predominated in sludge samples taken from nine lab- and full-scale EBPR systems (10-50% of total cells) and four conventional activated sludge systems (1-10%). Variation of predominance was also observed among those subgroups in systems showing deteriorated or effective EBPR activity.
Point-of-care, smartphone-based, dual-modality, dual-view, oral cancer screening device with neural network classification for low-resource communities (2018)

Oral cancer is a growing health issue in a number of low- and middle-income countries (LMIC), particularly in South and Southeast Asia. The described dual-modality, dual-view, point-of-care oral cancer screening device, developed for high-risk populations in remote regions with limited infrastructure, implements autofluorescence imaging (AFI) and white light imaging (WLI) on a smartphone platform, enabling early detection of pre-cancerous and cancerous lesions in the oral cavity with the potential to reduce morbidity, mortality, and overall healthcare costs. Using a custom Android application, this device synchronizes external light-emitting diode (LED) illumination and image capture for AFI and WLI. Data is uploaded to a cloud server for diagnosis by a remote specialist through a web app, with the ability to transmit triage instructions back to the device and patient. Finally, with the on-site specialist's diagnosis as the gold-standard, the remote specialist and a convolutional neural network (CNN) were able to classify 170 image pairs into 'suspicious' and 'not suspicious' with sensitivities, specificities, positive predictive values, and negative predictive values ranging from 81.25% to 94.94%.
Electrochromic Materials: Efficient Near Infrared Modulation with High Visible Transparency Using SnO2–WO3 Nanostructure for Advanced Smart Windows (Advanced Optical Materials 8/2019) (2019)

In article number 1801389, Tam D. Nguyen, Alfred Tok and co-workers present the fabrication of a hybrid SnO2–WO3 core–shell inverse opal (IO) structure by electro-deposition of an amorphous WO3 electrochromic layer on a highly transparent SnO2 IO framework. The SnO2–WO3 core–shell IO structure is able to block up to 90% near-infrared radiant heat and demonstrates optimal visible transparency of about 70% in the colored state.
Kinetic analysis of epoxy resins: Competing intermolecular and intramolecular polymerization reactions (1991)

SPACRCAN is a hyaluronan-binding proteoglycan that is present in the pineal gland and interphotoreceptor matrix of the retina. Here, we evaluate the pattern of SPACRCAN gene expression and protein appearance during retinal and pineal gland development in the rat. In situ hybridization histochemistry with SPACRCAN riboprobes indicates that hybridization signals are first evident in the retina over developing photoreceptor cells at embryonic day 16 (E16) and in the pineal gland at E21. Immunocytochemistry using a SPACRCAN antibody shows localization of SPACRCAN protein in the developing interphotoreceptor matrix by Postnatal day 5 (P5) and in the pineal gland by P6. These studies suggest that SPACRCAN mRNA expression may occur substantially earlier than the time when SPACRCAN protein is detectable in both the retina and the pineal gland. The period of retinal histogenesis when SPACRCAN is detected first is coincident with the time photoreceptors begin to extend from the outer retinal surface, suggesting that SPACRCAN may participate in the maturation and maintenance of the light-sensitive photoreceptor outer segment.
An extensive repertoire of type III secretion effectors in Escherichia coli O157 and the role of lambdoid phages in their dissemination (2006)

Several pathogenic strains of Escherichia coli exploit type III secretion to inject "effector proteins" into human cells, which then subvert eukaryotic cell biology to the bacterium's advantage. We have exploited bioinformatics and experimental approaches to establish that the effector repertoire in the Sakai strain of enterohemorrhagic E. coli (EHEC) O157:H7 is much larger than previously thought. Homology searches led to the identification of >60 putative effector genes. Thirteen of these were judged to be likely pseudogenes, whereas 49 were judged to be potentially functional. In total, 39 proteins were confirmed experimentally as effectors: 31 through proteomics and 28 through translocation assays. At the protein level, the EHEC effector sequences fall into >20 families. The largest family, the NleG family, contains 14 members in the Sakai strain alone. EHEC also harbors functional homologs of effectors from plant pathogens (HopPtoH, HopW, AvrA) and from Shigella (OspD, OspE, OspG), and two additional members of the Map/IpgB family. Genes encoding proven or predicted effectors occur in >20 exchangeable effector loci scattered throughout the chromosome. Crucially, the majority of functional effector genes are encoded by nine exchangeable effector loci that lie within lambdoid prophages. Thus, type III secretion in E. coli is linked to a vast phage "metagenome," acting as a crucible for the evolution of pathogenicity.
Corrigendum: Fragment‐Based Design of Ligands Targeting a Novel Site on the Integrase Enzyme of Human Immunodeficiency Virus 1 (2011)

Part of the work presented in the recently published Communication was carried out by Dr. Giang T. Le, formerly at Avexa Ltd (full affiliations given below). Dr. Le was unintentionally omitted from the author list but is a co-author of this paper. The corresponding authors apologise for this oversight. Dr. Giang T. Le Former address: Avexa Ltd, 576 Swan St, Richmond, Victoria 3121 (Australia) Current address: Alchemia Ltd, 3 Hi-Tech Court, Eight Mile Plains, Brisbane, Queensland 4113 (Australia).
Bleaching of cotton with activated peroxide systems (2005)

The bleaching performance of a novel cationic bleach activator, N ‐[4‐(triethylammoniomethyl)benzoyl]‐caprolactam chloride, was compared to that of nonanoyloxybenzene sulphonate, a commercially available anionic bleach activator. The whiteness of bleached cotton fabric was used as a measure of the performance. Comparison of bleach performance and the effect of key variables were evaluated using a central composite experimental design. The performances of both activators increased with temperature and sodium hydroxide concentration. Also, the performance of the cationic bleach activator increased with activator concentration, while an increase in the concentration of nonanoyloxybenzene sulphonate gave an adverse effect on the performance. It was found that the cationic bleach activator was superior to the anionic activator in the hot bleaching of cotton under the conditions studied.
Descriptive complexity and finite models : proceedings of a DIMACS workshop, January 14-17, 1996, Princeton University (1997)

Easier ways to win logical games by R. Fagin On the expression of graph properties in some fragments of monadic second-order logic by B. Courcelle Finite models, automata, and circuit complexity by H. Straubing Databases and finite-model theory by V. Vianu Why is modal logic so robustly decidable? by M. Y. Vardi Model checking and the mu-calculus by E. A. Emerson Algebraic propositional proof systems by T. Pitassi.
Experimental Targeting and Control of Spatiotemporal Chaos in Nonlinear Optics (2004)

We demonstrate targeting and control over spatiotemporal chaos in an optical feedback loop experiment. Different stationary target patterns are stabilized in real time by means of a two dimensional space extended perturbation field driven by an interfaced computer and applied in real space to a liquid crystal display device inserted within a control optical loop. The flexibility of the system in switching between different target patterns is also demonstrated.
Fed-batch liquefaction of sugarcane for endoglucanases production. (2018)

Made available in DSpace on 2018-01-24T22:13:21Z (GMT). No. of bitstreams: 1\nPFedBatchLiquefactionofSugarcane....pdf: 543416 bytes, checksum: bb5a00eff124fb7e412cf0ceadb848d1 (MD5)\n Previous issue date: 2018-01-23
Lightweight Polypropylene/Stainless-Steel Fiber Composite Foams with Low Percolation for Efficient Electromagnetic Interference Shielding (2014)

Lightweight polypropylene/stainless-steel fiber (PP-SSF) composites with 15-35% density reduction were fabricated using foam injection molding. The electrical percolation threshold, through-plane electrical conductivity, and electromagnetic interference (EMI) shielding effectiveness (SE) of the PP-SSF composite foams were characterized and compared against the solid counterparts. With 3 wt % CO2 dissolved in PP as a temporary plasticizer and lubricant, the fiber breakage was significantly decreased during injection molding, and well-dispersed fibers with unprecedentedly large aspect ratios of over 100 were achieved. The percolation threshold was dramatically decreased from 0.85 to 0.21 vol %, accounting for 75% reduction, which is highly superior, compared to 28% reduction of the previous PP-carbon fiber composite foam.1 Unlike the case of carbon fiber,1 SSFs were much longer than the cell size, and the percolation threshold reduction of PP-SSF composite foams was thus primarily governed by the decreased fiber breakage instead of fiber orientation. The specific EMI SE was also significantly enhanced. A maximum specific EMI SE of 75 dB·g(-1)·cm(3) was achieved in PP-1.1 vol % SSF composite foams, which was much higher than that of the solid counterpart. Also, the relationships between the microstructure and properties were discussed. The mechanism of EMI shielding enhancement was also studied.
Impella 5.0/5.5 Implantation via Innominate Artery: Further Expanding the Opportunities for Temporary Mechanical Circulatory Support (2022)

When axillary/subclavian arteries are not suitable because of size or anatomy, alternative access for the Impella pump 5.0/5.5 via the innominate artery allows circulatory support and eventually de-escalation from VA-ECMO to isolated left-side support. Moreover, less invasive surgery without the need to open the pericardium reduces the risk of RV dysfunction and bleeding. Finally, upper body strategies allow early rehabilitation during support, which is associated with improved survival in cardiogenic shock.
Fluorescence In Situ Hybridization for the Origin of De Novo Renal Cell Carcinoma in a Kidney Allograft: A Case Report (2021)

Fluorescence in situ hybridization clearly indicated that the tumor originated from the donor and that the tumor vasculature originated from the recipient. The patient recovered well and remains without any tumor recurrence.
Bendamustine/Mitoxantrone/Rituximab (BMR): A Very Effective, Well Tolerated Outpatient Chemoimmunotherapy for Relapsed and Refractory CD20-positive Indolent Malignancies. Final Results of a Pilot Study (2004)

We have developed a new chemoimmunotherapy for patients with relapsed or refractory CD20-positive indolent lymphomas and CLL by combining the chemotherapeutic agents Bendamustine (B) and Mitoxantrone (M) with the monoclonal antibody Rituximab. Treatment consisted of (B): 90 mg/m2 (80 mg/m2 in CLL) day 1 + 2, (M): 10 mg/m2 day 1 and (R): 375 mg/m2 day 8,15,22 and 29. BM was repeated 3 times starting on day 36, thereafter every 4 weeks. The maximal therapy consisted of 1 x BMR followed by 5 x BM. We have treated 54 patients with BMR. Median age was 68 years (36-82). Disease distribution was as follows: 21 B-CLL, 1 B-PLL, 8 lymphoplasmacytic, 14 follicular, 2 mantle cell, 2 marginal zone, 6 secondary high grade. Median number of previous treatments was 2 (1-7). ORR was 96% with 41% CR and 55% PR. Median time to progression is 17 months in CLL and has not been reached in indolent lymphomas with a median observation time of 27 months (3-60+). The time to next antilymphoma treatment is prolonged significantly by BMR. No therapy associated death or hospitalization occurred within the study period. BMR is a well tolerated very effective outpatient treatment for relapsed and refractory CD20-positive indolent lymphomas and CLL.
Regularization and improved interpretation of linear data mappings and adaptive distance measures (2013)

Linear data transformations are essential operations in many machine learning algorithms, helping to make such models more flexible or to emphasize certain data directions. In particular for high dimensional data sets linear transformations are not necessarily uniquely determined, though, and alternative parameterizations exist which do not change the mapping of the training data. Thus, regularization is required to make the model robust to noise and more interpretable for the user. In this contribution, we characterize the group of transformations which leave a linear mapping invariant for a given finite data set, and we discuss the consequences on the interpretability of the models. We propose an intuitive regularization mechanism to avoid problems in under-determined configurations, and we test the approach in two machine learning models.
Supplementary Figure 1 from Desmoglein 2 Functions as a Receptor for Fatty Acid Binding Protein 4 in Breast Cancer Epithelial Cells (2023)

&lt;p&gt;S1. DSC and DSG isoforms expressed in MCF-7 cells.&lt;/p&gt;
Pulse electrodeposited RuO2 electrodes for high-performance supercapacitor applications (2018)

The present work addresses high-performance Ruthenium Oxide (RuO 2 ) electrodes prepared by using a simple pulse electrodeposition method. For the comparison purpose, two different precursors, namely, ruthenium (III) nitrosyl sulphate (RuNS) and ruthenium trichloride (RuCl 3 ), were used in this study. The coatings were subjected to material characterisation such as Field Emission Scanning Electron Microscopy and Energy-Dispersive X-ray Spectroscopy, X-ray diffraction and Transmission electron microscopy as well as electrochemical characterisation such as Cyclic Voltammetry, Electrochemical Impedance Spectroscopy and charge/discharge. The RuNS–RuO 2 coating exhibited excellent specific capacitance (1724 F/g at 5 A/g) with a remarkable rate capability. This value is significantly higher (52%) than the value obtained for RuCl 3 –RuO 2 electrode material at 5 A/g. The findings provide valuable information on the potential use of RuNS as a precursor for synthesising RuO 2 and pulse electrodeposition process to produce electrodes for supercapacitors.
Adult Idiopathic Scoliosis (2021)

Navigation technology allows surgeons to better understand the spatial relationship between their intra-operative tool placement and their preoperative plans, thereby synergistically augmenting the precision of robotic-assisted surgery. In the author's opinion, preoperative planning for a surgery with complex anatomy is critical. This CT scan was entered into the robotic preoperative planning software to allow for detailed three-dimensional anatomic planning to achieve optimal implant location, density, and fixation. Careful preoperative planning is essential and in this case, was performed many days prior to the actual surgery. Implant location and size are known well before the surgery which improves intra-operative efficiency and can decrease cost by avoiding opening unnecessary instruments and implants for the surgery. The patient was prepared for surgery and draped in sterile manner along with the robotic apparatus. The reference frames on the robot and surgical instruments were then confirmed to have adequate lines of sight with the navigation camera.
Thermally induced gelable polymer networks for living cell encapsulation (2006)

We report the encapsulation of MIN6 cells, a pancreatic beta-cell line, using thermally induced gelable materials. This strategy uses aqueous solvent and mild temperatures during encapsulation, thereby minimizing adverse effects on cell function and viability. Using a 2:1 mixture of PNIPAAm-PEG-PNIPAAm tri-block copolymer and PNIPAAm homopolymer that exhibit reversible sol-to-gel transition at approximately 30 degrees C, gels were formed that exhibit mechanical integrity, and are stable in H(2)O, PBS and complete DMEM with negligible mass loss at 37 degrees C for 60 days. MTT assays showed undetectable cytotoxicity of the polymers towards MIN6 cells. A simple microencapsulation process was developed using vertical co-extrusion and a 37 degrees C capsule collection bath containing a paraffin layer above DMEM. Spherical capsules with diameters ranging from 500 to 900 microm were formed. SEM images of freeze-dried capsules with PBS as the core solution showed homogenous gel capsule membranes. Confocal microscopy revealed that the encapsulated cells tended to form small aggregates over 5 days, and staining for live and dead cells showed high viability post-encapsulation. A static glucose challenge with day-5 cultured microencapsulated cells exhibited glucose-dependent insulin secretion comparable to controls of free MIN6 cells grown in monolayers. These results demonstrate the potential use of these thermo-responsive polymers as cell encapsulation membranes.
Control of T Cell Function by Positive and Negative Regulators (2002)

T cells are an essential element of the body's immune system. Engagement of the T cell receptor is responsible for initiating the signaling events that can activate, inactivate, or eliminate T cells, depending on the magnitude and duration of the signal. Control of T cell signaling occurs through both positive and negative regulation, as well as through the actions of molecular scaffolds that contribute to the formation of signaling complexes. The T Cell Signal Transduction Pathway at the STKE Connections Maps highlights the molecular components that are responsible for T cell activation. Understanding the mechanisms that regulate T cell responsiveness will aid in the development of therapeutic agents to treat infection, cancer, and autoimmune disease and immune deficiency.
Enhancing Energy Efficiency in Multi-tier Web Server Clusters via Prioritization (2007)

This paper investigates the design issues and energy savings benefits of service prioritization in multi-tier Web server clusters. In many services, classes of clients can be naturally assigned different priorities based on their performance requirements. We show that if the whole multi-tier system is effectively prioritized, additional power and energy savings are realizable while keeping an existing cluster-wide energy management technique, through exploiting the different performance requirements of separate service classes. We find a simple prioritization scheme to be highly effective without requiring intrusive modifications to the system. In order to quantify its benefits, we perform extensive experimental evaluation on a real testbed. It is shown that the scheme significantly improves both total system power savings and energy efficiency, at the same time as improving throughput and enabling the system to meet per-class performance requirements.