gebhart/patrepeval huggingface dataset:
Implanted pulsatile balloon device for simulation of neurovascular compression syndromes in animals (1982)

A self-contained neurovascular compression simulator (NCS) has been designed to function as an artificial artery that pulsates with the heart. When implanted in animals, this device simulates those naturally occurring situations in which there is compression of nervous elements in the region of the brain stem or other areas by aberrant, or ectatic branches of normal arteries. The NCS consists of an intra-aortic balloon, a smaller (cephalic) balloon, a connecting tube, and an injection port, all fabricated of polyurethane-silicone compounds. With each heart systole, the rise in intra-aortic pressure is transmitted to the smaller cephalic balloon in the form of a pulsation. Thus, part of the cardiac ejection energy is transferred to the desired nervous structures. The performance of each NCS is tested in vitro in a pulse duplicator system. The NCS was chronically implanted for up to 2 years in four dogs and 10 baboons. The cephalic balloon was placed intracranially in the subarachnoid space on the ventrolateral medulla adjacent to the entry zone of the ninth and 10th cranial nerves on the left side of baboons and on the right side of dogs. The position of the balloons was checked by fluoroscopy. Following implantation, the NCS could be inflated or deflated at will using the injection port which served to restart or discontinue the pulsations. No occlusion of the aorta or reduction of blood flow to the lower limbs or trunk was detected. By means of the NCS, an experimental model of neurogenic hypertension was produced in baboons.
Walking Compared With Vigorous Physical Activity and Risk of Type 2 Diabetes in Women (2000)

Hu, F B; Sigal, R J; Rich-Edwards, J W; Colditz, G A; Solomon, C G; Willett, W C; Speizer, F E; Manson, J EEditor(s): Cannistra, Lauralyn MD; Carlin, Brian MD; Keteyian, Steven J. PhD
A Giant Electrocaloric Effect in Nanoscale Antiferroelectric and Ferroelectric Phases Coexisting in a Relaxor Pb0.8Ba0.2ZrO3 Thin Film at Room Temperature (2013)

Abstract Recently, large electrocaloric effects (ECE) in antiferroelectric sol‐gel PbZr 0.95 Ti 0.05 O 3 thin films and in ferroelectric polymer P(VDF‐TrFE)55/45 thin films were observed near the ferroelectric Curie temperatures of these materials (495 K and 353 K, respectively). Here a giant ECE (Δ T = 45.3 K and Δ S = 46.9 J K −1 kg −1 at 598 kV cm −1 ) is obtained in relaxor ferroelectric Pb 0.8 Ba 0.2 ZrO 3 (PBZ) thin films fabricated on Pt(111)/TiO x /SiO 2 /Si substrates using a sol‐gel method. Nanoscale antiferroelectric (AFE) and ferroelectric (FE) phases coexist at room temperature (290 K) rather than at the Curie temperature (408 K) of the material. The giant ECE in such a system is attributed to the coexistence of AFE and FE phases and a field‐induced nanoscale AFE to FE phase transition. The giant ECE of the thin film makes this a promising material for applications in cooling systems near room temperature.
Синтетический конформационный антиген, моделирующий внеклеточную часть мускаринового М2-рецептора, и его взаимодействие с сыворотками крови пациентов с идиопатическими аритмиями (2013)

Linear peptides corresponding to fragment 83-98 of the first loop and fragments 168-192 and 171-182 of the second extracellular loops of M2-muscarinic receptor (marker of early cardiac disorders and arrhythmias) were synthesized by Fmoc-SPPS method. A new conformational antigen was synthesized by method of selective ligation of linear peptides by disulfide bond with native localization. Peptides were studied in reaction with sera from patients with idiopathic arrhythmias. A new conformational antigen was recognized by sera from patients with idiopathic arrhythmias with high reactivity.
Stable Egress Route Selection for Interdomain Traffic Engineering: Model and Analysis (2006)

We present a general model of interdomain route selection to study interdomain traffic engineering. In this model, the routing of multiple destinations can be coordinated. Thus the model can capture general traffic engineering behaviors such as load balancing and link capacity constraints. We first identify potential routing instability and inefficiency of interdomain traffic engineering. We then derive a sufficient condition to guarantee convergence. We also show that the constraints on local policies imposed by business considerations in the Internet can guarantee stability without global coordination. Using realistic Internet topology, we evaluate the extent to which routing instability of interdomain traffic engineering can happen when the constraints are violated.
The grapevine gene nomenclature system (2014)

Learning from similar initiatives in other plant species such as Arabidopsis, rice and tomato, a versatile nomenclature system has been developed in anticipation of future genomic developments and annotation issues. The sNCGGa's first outreach to the grape community has been focused on implementing recommended guidelines for the expert annotators by: (i) providing a common annotation platform that enables community-based gene curation, (ii) developing a gene nomenclature scheme reflecting the biological features of gene products that is consistent with that used in other organisms in order to facilitate comparative analyses.
The Evolution of Materials for the Photolithographic Process (2003)

Underlying the rapid growth of the semiconductor field is a significant advancement in the materials utilized in the photolithographic process. In order to produce smaller devices, exposure wavelengths are decreased. Each wavelength reduction has demanded the synthesis of novel materials that are not only transparent at the new wavelength, but also meet all of the requirements of an effective resist polymer. The transition from 248 nm exposures to 193 nm precluded the use of aromatic functional groups, and the recent drop to 157 nm exposure has inspired a large amount of effort toward the development of resist materials containing fluorine. The Semiconductor Industry Association (SIA) roadmap predicts the use of extreme ultra-violet (EUV) radiation as the next move for the industry, but the high cost and high energy associated with this technology may make alternative lithographic technologies seem more practical.
Calibration of mass and conventional mass of weights between INACAL–CENAM–CESMEC (SIM.M.M-S13) (2017)

This supplementary comparison was piloted by the Instituto Nacional de Calidad (INACAL, Peru) and describes the results of the comparison in mass and conventional mass in weights of 2 kg and 10 kg between INACAL-PERU, CENAM-MEXICO and CESMEC-CHILE. The travelling standards were OIML class E2 weights of stainless steel. INACAL measured the volume of the traveling standards of 10 kg and the volume value used for the 2 kg mass standard was provided by the PTB. To reach the main text of this paper, click on Final Report . Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/ . The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
A phase I study of pazopanib in combination with escalating doses of 131I in patients with well-differentiated thyroid carcinoma borderline refractory to radioiodine (2017)

ClinicalTrials.gov NCT01413113.
A Molecular Test for Quantifying Functional Notch Signaling Pathway Activity in Human Cancer (2020)

High Notch pathway activity was not limited to T-ALL samples harboring strong NOTCH1 mutations, including juxtamembrane domain mutations or hetero-dimerization combined with PEST-domain or FBXW7 mutations, indicating that additional mechanisms may activate Notch signaling. The measured Notch pathway activity was related to intracellular NOTCH levels, indicating that the pathway activity score more accurately reflects Notch pathway activity than when it is predicted on the basis of NOTCH1 mutations. Importantly, patients with low Notch pathway activity had a significantly shorter event-free survival compared to patients showing higher activity.
Elevated glycolysis imparts functional ability to CD8+ T cells in HIV infection (2021)

The mechanisms inducing exhaustion of HIV-specific CD8<sup>+</sup> T cells are not fully understood. Metabolic programming directly influences T-cell differentiation, effector function, and memory. We evaluated metabolic profiles of ex vivo CD8<sup>+</sup> T cells in HIV-infected individuals. The baseline oxygen consumption rate of CD8<sup>+</sup> T cells was elevated in all infected individuals and CD8<sup>+</sup> T cells were working at maximal respiratory capacity. The baseline glycolysis rate was enhanced only during early untreated HIV and in viral controllers, but glycolytic capacity was conserved at all stages of infection. CD8<sup>+</sup> T-cell mTOR activity was found to be reduced. Enhanced glycolysis was crucial for HIV-specific killing of CD8<sup>+</sup> T cells. CD8<sup>+</sup> T-cell cytoplasmic GAPDH content was reduced in HIV, but less in early infection and viral controllers. Thus, CD8<sup>+</sup> T-cell exhaustion in HIV is characterized by reduced glycolytic activity, enhanced OXPHOS demands, dysregulated mTOR, and reduced cytoplasmic GAPDH. These data provide potential metabolic strategies to reverse CD8<sup>+</sup> T-cell dysfunction in HIV.
Characterization by infrared and Raman spectroscopy of matrix-isolated M(CO)5N2 (M = chromium, molybdenum, or tungsten) produced by photolysis of M(CO)6 (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCharacterization by infrared and Raman spectroscopy of matrix-isolated M(CO)5N2 (M = chromium, molybdenum, or tungsten) produced by photolysis of M(CO)6Jeremy K. Burdett, Anthony J. Downs, Geoffrey P. Gaskill, Michael A. Graham, James J. Turner, and Robert F. TurnerCite this: Inorg. Chem. 1978, 17, 3, 523–532Publication Date (Print):March 1, 1978Publication History Published online1 May 2002Published inissue 1 March 1978https://pubs.acs.org/doi/10.1021/ic50181a002https://doi.org/10.1021/ic50181a002research-articleACS PublicationsRequest reuse permissionsArticle Views379Altmetric-Citations40LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Bioassay-Guided Isolation of Fungistatic Compounds from Mimosa caesalpiniifolia Leaves (2019)

A bioassay-guided phytochemical study of a <i>Mimosa caesalpiniifolia</i> leaf extract with antifungal activity permitted the identification of 28 compounds, including the new 6-(β<i>-</i>boivinopyranosyl)apigenin (<b>1</b>), 8-(β<i>-</i>oliopyranosyl)apigenin (<b>2</b>), (<i>E</i>)-6-(2-carboxyethenyl)apigenin (<b>3</b>), (<i>E</i>)-8-(2-carboxyethenyl)apigenin (<b>4</b>), and 7,5″-anhydro-6-(α-2,6-dideoxy-5-hydroxyarabinohexopyranosyl)apigenin (<b>5</b>). The structures of the new compounds were determined by comprehensive spectroscopic analysis, including 1D and 2D NMR techniques, and by mass spectrometry. Compound <b>3</b> showed promising activity and selectivity against <i>Candida krusei</i> (IC<sub>50</sub> 44 nM), which exhibits resistance to azoles. The association of the major components 3-β-d-glucopyranosyloxysitosterol (<b>8</b>) and ethyl gallate (<b>10</b>) was synergistic against <i>C. krusei</i>, especially the IC values of compound <b>10</b>, which were reduced by more than 100-fold.
Relativistic electron beam cyclotron wave growth in helical slow wave structures (1977)

One of the more promising and thoroughly studied proposals for high energy collective ion acceleration is Autoresonant Acceleration: Ions trapped in the electrostatic wells of large amplitude slow cyclotron waves in an unneutralized intense relativistic electron beam are accelerated by the increase of wave phase velocity as the beam propagates along a magnetic guide field of decreasing strength. A critical component of this scheme is growth of coherent, large amplitude waves. A discussion is given of wave growth by interaction of the beam with a helical slow wave structure. Specific topics include: (1) equilibrium charge and current distributions on the helix; (2) linear wave growth spectra including the effects of radial inhomogeneity; (3) wave growth and saturation; and (4) extraction of cyclotron waves from the amplifier cavity. Movies of two-dimensional computer simulations were made. It was found that waves of amplitude adequate for planned feasibility experiments can indeed be obtained.
Characterization of a cDNA encoding RP43, a CUB-domain-containing protein from the tube of Riftia pachyptila (Vestimentifera), and distribution of its transcript (2000)

A major 43 kDa protein from the protective tube of Riftia pachyptila (Vestimentifera), named RP43, was partly microsequenced after isolation by SDS/PAGE from the protein fraction of tubes collected around the hydrothermal vents at the East Pacific Rise. On the basis of the partial peptide sequences obtained, experiments using reverse-transcriptase-mediated PCR and rapid amplification of cDNA ends led to the complete cDNA sequence. Analysis of deduced amino acid sequence of RP43 showed the presence of CUB domains (100-110-residue-spanning domains first reported in the complement subcomponents C1r/C1s, epidermal-growth-factor-related sea urchin protein and bone morphogenetic protein 1) that seem to be involved in protein-protein and glycosaminoglycan-protein interactions. This peculiarity strongly suggests that RP43 might have a crucial role in tightening the different elements of the worm tube. However, the absence of chitin-binding motifs inclines us to favour a role in protein-protein interactions during assembly of the tube components. The RP43 mRNA was found to be present in specific epidermal cells from the worm body wall but never in the chitin-synthesizing gland cells. This unexpected result clearly indicates that the major tube protein is synthesized in specialized areas of the outer epithelium and that at least two different tissues are involved in the synthesis of the exoskeleton.
Enhanced Hydrogen Production from DNA‐Assembled Z‐Scheme TiO2–CdS Photocatalyst Systems (2015)

Abstract A wide range of inorganic nanostructures have been used as photocatalysts for generating H 2 . To increase activity, Z‐scheme photocatalytic systems have been implemented that use multiple types of photoactive materials and electron mediators. Optimal catalysis has previously been obtained by interfacing different materials through aggregation or epitaxial nucleation, all of which lowers the accessible active surface area. DNA has now been used as a structure‐directing agent to organize TiO 2 and CdS nanocrystals. A significant increase in H 2 production compared to CdS or TiO 2 alone was thus observed directly in solution with no sacrificial donors or applied bias. The inclusion of benzoquinone (BQ) equidistant between the TiO 2 and CdS through DNA assembly further increased H 2 production. While the use of a second quinone in conjunction with BQ showed no more improvement, its location within the Z‐scheme was found to strongly influence catalysis.
Murine macrophages lack expression of the Cr2‐145 (CR2) and Cr2‐190 (CR1) gene products (1993)

Murine macrophages have been described as possessing complement receptors for C3b and iC3b. These binding activities have been assumed to be due to the presence of the CR1 and CR3 proteins, respectively. The mouse Cr2 gene produces two distinct gene products of approximately 190,000 relative molecular mass (M(r)) (Cr2-190) and 145,000 M(r) (Cr2-145). Because of the similarity in size to human complement receptors, the Cr2-190 protein has been dubbed murine CR1 while the murine Cr2-145 product has been termed murine CR2. In order to define the complement receptor genes expressed by murine macrophages, we investigated the expression patterns of Cr2-190, Cr2-145 and another mouse complement receptor, Crry, in three different mouse macrophage populations: bone marrow-derived macrophages, thioglycollate-elicited peritoneal macrophages and the macrophage cell line, J774. Neither of the Cr2 gene transcripts encoding the Cr2-145 and Cr2-190 proteins could be detected in these populations by RT-RPCR analysis although Crry transcripts were evident. Cr2-145 and Cr2s-190 proteins could not be detected on the surface of thioglycollate-elicited macrophages using a monoclonal antibody that recognizes both proteins. Thus, contrary to previously published data, murine macrophages do not possess the Cr2 gene products.
Air-Ground Doppler-delay spread spectrum for dense scattering environments (2015)

Applications using Air-Ground communications are expected to grow in the future. Low altitude phases of these wireless links are considered sever channels, as they experience huge delay and Doppler spreads, however, they are not yet accurately characterized in the literature. This paper presents an analytic three dimensional Air-Ground Doppler-delay spread spectrum model for dense scattering environments. The analysis is done by revisiting previous work in the literature. Also a Terrain based Doppler-delay spectrum simulator is proposed, where the results are verified using a real Digital Elevation Model (DEM).
VLSI Friendly ECG QRS Complex Detector for Body Sensor Networks (2012)

This paper aims to present a very-large-scale integration (VLSI) friendly electrocardiogram (ECG) QRS detector for body sensor networks. Baseline wandering and background noise are removed from original ECG signal by a mathematical morphological method. Then the multipixel modulus accumulation is employed to act as a low-pass filter to enhance the QRS complex and improve the signal-to-noise ratio. The performance of the algorithm is evaluated with standard MIT-BIH arrhythmia database and wearable exercise ECG Data. Corresponding power and area efficient VLSI architecture is designed and implemented on a commercial nano-FPGA. High detection rate and high speed demonstrate the effectiveness of the proposed detector.
Drug and Natural Product Binding to Nucleic Acids Analyzed by Electronic Circular Dichroism (2012)

This chapter contains sections titled: Introduction Diagnostic Electronic CD Spectral Changes on Drug–DNA Binding Illustrative Examples of Minor Groove and Intercalative Natural Product–DNA Binding Illustrative Examples of the Selective Binding of Porphyrins to B- and Z-Form DNA Illustrative Examples of the Selective Binding of Porphyrins and Alkaloids to G-Quadruplex DNA Concluding Comments Acknowledgments References
Optimization of Interference Cancellation in Coded CDMA Systems by Means of Differential Evolution (2006)

This paper introduces an optimization of the received power profile for iterative parallel and successive interference cancellation (PIC/SIC) in coded CDMA systems. The basic approach is an optimization algorithm called Differential Evolution (DE). An optimized power allocation of the users at the transmitter is an important means for enhancing the convergence behavior of the detector. Either the supportable load can be significantly increased or the required transmit power is decreased by several dB. Furthermore any additional constraint regarding the modelling of realistic communication systems can be implemented very easily. In this paper the number of needed iterations is dramatically decreased. Computational complexity is reduced while the needed power is barely increased. Another constraint which is also considered is the near-far-effect that degenerates system performance. The maximum received power is limited for some users that are assumed to be at the cell border or who suffer from fading. The precondition for this optimization is the analysis of the iterative detection scheme. This is done by a parameter called multi-user efficiency (MUE). 1
Sensitivity, specificity and predictive values of the secretin infusion test in the diagnosis of gastrinoma. (1986)

From 1974 to 1981, 55 patients, 18 with Zollinger-Ellison syndrome (ZES) histologically confirmed and 37 patients with duodenal ulcer (DU) without pylorostenosis were followed for a minimal period of 5 years. The diagnostic values of a) basal acid output (BAO mEq/h); b) 60 min acid output after secretin infusion, 3 CU-GIH/kg, (MAO-SE mEq/h); c) basal serum gastrin (BSG pg/ml: mean of 4 gastrin determinations) and d) serum gastrin after secretin (SG-SE pg/ml: mean of 4 gastrin determinations during secretin infusion) were calculated. Cut off point values of 100 p. 100 specificity (i. e. no DU patient reached these values) with a positive predictive value of 100 p. 100 (i. e. probability for gastrinoma when this cut off point was attained) were BAO greater than 26 mEq/h, MAO-SE greater than 18 mEq/h, BSG greater than 221 pg/ml, SG-SE greater than 186 pg/ml. The sensitivities of these parameters (i. e. percent of ZES which reached the given cut off point) were respectively (p. 100): 39, 78, 72 and 94. Ranking these parameters according to their own discriminative value expressed by R2 (square correlation coefficient) gave SG-SE, R2 = 0.559; BSG, R2 = 0.508; MAO-SE, R2 = 0.456; BAO, R2 = 0.414. The most discriminative association of 2 variables was SG-SE and MAO-SE (R2 = 0.650). Association of SG-SE, MAO-SE and BAO or BSG (or BAO and BSG) did not increase significantly the discrimination between ZES and DU (R2 = 0.672).
R-TOD: Real-Time Object Detector with Minimized End-to-End Delay for Autonomous Driving (2020)

For realizing safe autonomous driving, the end-to-end delays of real-time object detection systems should be thoroughly analyzed and minimized. However, despite recent development of neural networks with minimized inference delays, surprisingly little attention has been paid to their end-to-end delays from an object's appearance until its detection is reported. With this motivation, this paper aims to provide more comprehensive understanding of the end-to-end delay, through which precise best- and worst-case delay predictions are formulated, and three optimization methods are implemented: (i) on-demand capture, (ii) zero-slack pipeline, and (iii) contention-free pipeline. Our experimental results show a 76% reduction in the end-to-end delay of Darknet YOLO (You Only Look Once) v3 (from 1070 ms to 261 ms), thereby demonstrating the great potential of exploiting the end-to-end delay analysis for autonomous driving. Furthermore, as we only modify the system architecture and do not change the neural network architecture itself, our approach incurs no penalty on the detection accuracy.