gebhart/patrepeval huggingface dataset:
Characterization of genetic predisposition and autoantibody profile in atypical haemolytic–uraemic syndrome (2018)

We previously reported that Indian paediatric patients with atypical haemolytic-uraemic syndrome (aHUS) showed high frequencies of anti-complement factor H (FH) autoantibodies that are correlated with homozygous deletion of the genes for FH-related proteins 1 and 3 (FHR1 and FHR3) (FHR1/3<sup>-/-</sup> ). We now report that Indian paediatric aHUS patients without anti-FH autoantibodies also showed modestly higher frequencies of the FHR1/3<sup>-/-</sup> genotype. Further, when we characterized epitope specificities and binding avidities of anti-FH autoantibodies in aHUS patients, most anti-FH autoantibodies were directed towards the FH cell-surface anchoring polyanionic binding site-containing C-terminal short conservative regions (SCRs) 17-20 with higher binding avidities than for native FH. FH SCR17-20-binding anti-FH autoantibodies also bound the other cell-surface anchoring polyanionic binding site-containing region FH SCR5-8, at lower binding avidities. Anti-FH autoantibody avidities correlated with antibody titres. These anti-FH autoantibody characteristics did not differ between aHUS patients with or without the FHR1/3<sup>-/-</sup> genotype. Our data suggest a complex matrix of interactions between FHR1-FHR3 deletion, immunomodulation and anti-FH autoantibodies in the aetiopathogenesis of aHUS.
Preoperative embolization of hypervascular head and neck neoplasms using microfibrillar collagen. (1982)

Microfibrillar collagen is a bovine collagen material that promotes hemostasis. When mixed with contrast material it makes a fine slurry that is easily injected through small catheters. Experience with preoperative embolization of head and neck neoplasms in six patients indicates that microfibrillar collagen slurry is a highly effective, easy to use embolic material for occlusion of highly vascular neoplasms.
Oxygen Reduction Reaction (ORR) on a Mixed Titanium and Tantalum Oxy-nitride Catalyst Prepared by the Urea-based Sol-gel Method (2014)

The electrochemical stability and activity of different compositions of titanium and tantalum oxy-nitride nano-catalysts were investigated for the oxygen reduction reaction (ORR). A new sol-gel method was used to produce a nano-powder mixture of Ti and Ta oxynitride from their alkoxides using urea as a nitrogen source. The precursors prepared by the sol-gel method were annealed in a N2 + 3% H2 atmosphere at determined temperatures (500, 700 and 900 °C) inside a silica tube furnace. X-ray diffraction results proved that by using this method a considerable amount of nitrogen was inserted into the catalyst structure at a relatively low temperature. Energy dispersive spectroscopy showed that the prepared catalyst should be oxidized carbonitride of titanium and/or tantalum. Heat treatment had a major effect on the onset potential by changing the crystallinity of the catalyst, so that the onset potential of titanium oxynitride increased from ca. 0.05 V to 0.65 V vs. NHE by increasing the temperature from 500 to 700 °C. Increasing the Ta concentration also led to a higher onset potential but lower ORR current. For instance, the onset potential for the ORR for tantalum oxynitride heat treated at 700 °C was ca. 0.85 V vs. NHE while this value was ca. 0.65 V vs. NHE for titanium oxynitride. However, the ORR current was 100 times smaller in tantalum oxynitride, most likely because of a low electrochemically active surface area. Electrochemical measurements suggested that an appropriate composition of titanium and tantalum was required to have both a good onset potential and ORR current by improving the catalytic activity and increasing the active surface area and electrical conductivity.
A formal executable specification of the GinMAC protocol for Wireless Sensor Actuator Networks (2013)

The inception of Wireless Sensor Actuator Networks from the existing Wireless Sensor Networks domain was motivated by the need to satisfy the requirements of automation applications. Automation applications cover a broad domain from industrial automation, home automation to automation in body area networks and have specific real-time requirements differing from each other depending on the criticality of the application. Given the complex nature of WSAN, efficient techniques are required to obtain error-free protocol designs. Formal specification languages like Coloured Petri Nets assist designers to capture this complexity. GinMAC is a Medium Access Control (MAC) protocol that aims at satisfying the real-time requirements laid down by the Wireless Sensor Actuator Networks applications. In this article, we provide a formal executable specification for the GinMAC protocol. With this formal executable model, we precisely capture the abstract features of this protocol and analyze it. Our formal executable model is platform independent and can be used as a basis for further analysis of the protocol or any protocol extensions that are made to this protocol. The platform independence allows us to convert this model to various other analysis tools including model checkers, network simulators, and hardware emulators.
Relevance of the exopolysaccharide of marine Pseudomonas sp. strain S9 for the attachment of Ciona intestinalis larvae (1991)

Effects of bactenal exopolymers on the attachment of larvae of the ascidian Ciona intestinalis were examined in the laboratory. A marine Pseudomonas sp. (strain S9) which forms and excretes a penpheral exopolysaccharide during energy and nutrient starvation was used as a test organism. The experiments also focused on inhibition of exopolymer excretion and the use of a transposon-generated mutant that was deficient in the release of peripheral exopolymer. Two modes of larval attachment to surfaces coated with bacteria could be distinguished, depending on the amount of peripheral exopolysaccharide present: active attachment by use of the adhesive organs, and passive attachment due to trapping of the larvae in the exopolymer matenal. All larvae underwent metamorphosis and could therefore contribute to population recruitment. A similar increase in the extent of attachment In the presence of peripheral exopolysaccharide could b e observed for both fertilized and non-fertilized eggs. Our findings show that exopolymers produced by bacteria may increase the extent of attachment of C. intestinalis larvae.
Parallel single wall carbon nanotubes for microwave applications (2009)

Carbon nanotube transmission line is characterized by slow wave velocity which can be considered as an important feature in size reduction of microwave circuits. However, equivalent characteristic impedance and Ohmic contacts of single carbon nanotube are much higher than the usual impedance values that are used in antennas and microwave circuits. This paper introduces the basic theory of parallel single wall carbon nanotubes showing how it can be used to synthesis equivalent transmission line sections of appropriate characteristic impedances and slow wave velocity too. Such transmission line sections can be used to develop reduced size microwave circuits.
Neuroprotective effects of brilliant blue G on the brain following traumatic brain injury in rats (2015)

The P2X7 inhibitor, brilliant blue G (BBG), has been reported as a neuroprotective drug against a variety of disorders, including neuropathic pain and brain ischemia. Currently, no studies have examined the potential for BBG to provide neuroprotection in animal models of TBI. The aim of the present study was to investigate the neuroprotective effect of BBG on TBI and to determine the underlying mechanisms. The rats were subjected to a diffuse cortical impact injury caused by a modified weight-drop device, and then divided randomly into three groups: the sham-operated, BBG treatment and vehicle groups. In the BBG treatment group, 50 mg/kg brilliant blue G (BBG; 100% pure), a highly specific and clinically useful P2X7 antagonist, was administered via the tail vein 15 min prior to or up to 8 h following TBI. The co-localization of NeuN and protein kinase Cγ (PKCγ) was followed with immunofluorescent staining. The expression of P2X7, PKCγ and inflammatory cytokines was identified by western blot analysis. Wet-dry weight method was used to evaluate brain edema, and motor function outcome was examined using the neurological severity score. The present study demonstrated that the administration of BBG attenuated TBI-induced cerebral edema and the associated motor deficits. Following trauma, BBG treatment significantly reduced the levels of PKCγ and interleukin-1β in the cortex. The results provide in vivo evidence that BBG exerted neuroprotective effects by attenuating brain edema and improving neurological functions via reducing PKCγ and interleukin-1β levels following TBI.
Mineralogical and Geochemical Trends in a Fluviolacustrine Sequence in Gale Crater, Mars (2016)

The Mars Science Laboratory rover, Curiosity, landed at Gale crater in August 2012 and has been investigating a sequence of dominantly fluviolacustrine sediments deposited 3.6-3.2 billion years ago. Curiosity collects quantitative mineralogical data with the CheMin XRD/XRF instrument and quantitative chemical data with the APXS and ChemCam instruments. These datasets show stratigraphic mineralogical and geochemical variability that suggest a complex aqueous history. The Murray Formation, primarily composed of fine-laminated mudstone, has been studied in detail since the arrival at the Pahrump Hills in September 2014. CheMin data from four samples show variable amounts of iron oxides, phyllosilicates, sulfates, amorphous and crystalline silica, and mafic silicate minerals. Geochemical data throughout the section show that there is significant variability in Zn, Ni, and Mn concentrations. Mineralogical and geochemical trends with stratigraphy suggest one of possibly several aqueous episodes involved alteration in an open system under acidic pH, though other working hypotheses may explain these and other trends. Data from the Murray Formation contrast with those collected from the Sheepbed mudstone located approximately 60 meters below the base of the Murray Formation, which showed evidence for diagenesis in a closed system at circumneutral pH. Ca-sulfates filled late-stage veins in both mudstones.
Cultured vestibular ganglion neurons demonstrate latent HSV1 reactivation (2011)

VGNs can be both lytically and latently infected with HSV1. Furthermore, latently infected VGNs can be induced to reactivate using TSA. This demonstrates that reactivation of latent HSV1 infection in the vestibular ganglion can occur in a cell culture model, and suggests that reactivation of HSV1 infection a plausible etiologic mechanism of vestibular neuritis.
Very large gastric ulcer with a round lesion: Figure 1 (2009)

A 56-year-old Japanese woman was admitted to our hospital with a 1-month history of abdominal fullness and a 1-year history of body weight loss of 10 kg. There was no significant family history nor history of previous abdominal surgery. There was …
Millimeter-wave MIMO radar system using L-shaped Tx and Rx arrays (2016)

This paper proposes L-shaped Tx and Rx arrays for MIMO Radar, which enable to enhance azimuth and elevation angular resolution to the maximum under the limitation on the number of the array elements. The proposed L-shaped Tx and Rx arrays include unequally spacing between array elements to be minimum redundancy array on the virtual Rx array, and 2D array interpolation on the Rx virtual array is proposed in order to suppress sidelobes in 2D angular profiles. Computer simulation and experimental measurements have been done for verification. Consequently, our work proves the effectiveness of the proposed MIMO radar array to enhance angular resolution in MIMO radar systems.
Nuclear Radiation Fields on the Mars Surface: Risk Analysis for Long-term Living Environment (2005)

&lt;div class="htmlview paragraph"&gt;Mars, our nearest planet outward from the sun, has been targeted for several decades as a prospective site for expanded human habitation. Background space radiation exposures on Mars are expected to be orders of magnitude higher than on Earth. Recent risk analysis procedures based on detailed dosimetric techniques applicable to sensitive human organs have been developed along with experimental data regarding cell mutation rates resulting from exposures to a broad range of particle types and energy spectra. In this context, simulated exposure and subsequent risk for humans in residence on Mars are examined. A conceptual habitat structure, CAD-modeled with duly considered inherent shielding properties, has been implemented. Body self-shielding is evaluated using NASA standard computerized male and female models. The background environment is taken to consist not only of exposure from incident cosmic ray ions and their secondaries, but also include the contribution from secondary neutron fields produced in the tenuous atmosphere and the underlying regolith.&lt;/div&gt;
The small compound Icerguastat reduces muscle defects in oculopharyngeal muscular dystrophy through the PERK pathway of the unfolded protein response (2023)

Oculopharyngeal muscular dystrophy (OPMD) is an autosomal dominant disease characterized by the progressive degeneration of specific muscles. OPMD is due to a mutation in the gene encoding poly(A) binding protein nuclear 1 (PABPN1) leading to a stretch of 11 to 18 alanines at N-terminus of the protein, instead of 10 alanines in the normal protein. This alanine tract extension induces the misfolding and aggregation of PABPN1 in muscle nuclei. Here, using <i>Drosophila</i> OPMD models, we show that the unfolded protein response (UPR) is activated in OPMD upon endoplasmic reticulum stress. Mutations in components of the PERK branch of the UPR reduce muscle degeneration and PABPN1 aggregation characteristic of the disease. We show that oral treatment of OPMD flies with Icerguastat (previously IFB-088), a Guanabenz acetate derivative that shows lower side effects, also decreases muscle degeneration and PABPN1 aggregation. Furthermore, the positive effect of Icerguastat depends on GADD34, a key component of the phosphatase complex in the PERK branch of the UPR. This study reveals a major contribution of the ER stress in OPMD pathogenesis and provides a proof-of-concept for Icerguastat interest in future pharmacological treatments of OPMD.
The Yin-Yang of Sirtuins (2007)

Two related proteins protect cells from age-associated neurodegenerative disease, but one needs to be activated whereas the other must be inhibited.
Determination of Cost Savings Using Variable Speed Fans for Cooling Servers (2020)

This paper addresses how different control schemes for fans used to cool servers can affect energy consumption. An analytical model that includes physical parameters of a heat source/heat sink/fan was developed. As a case study, an air duct with a DC fan, heat sink and heat source was built. Experiments were performed to generate physical parameters used as inputs to the model. Three fan control methods - variable speed, on/off and low/high speed fan controls - were modelled using MATLAB and Simulink to compare fan speed behavior, target chip desired temperature and saving in fan electrical energy. Potential savings in air conditioning power were also estimated. Simulation results show that variable speed fan control can save more energy than other fan control types, especially on/off control. The model developed can also be used by practitioners to explore the trade-offs between fan and air conditioning power.
A General Method for the Direct α‐Arylation of Nitriles with Aryl Chlorides. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
8-Ethenyl-1-hydroxy-4-.beta.-D-ribofuranosylbenzo[d]naphtho[1,2-b]pyran-6-one and 8-ethenyl-1-hydroxy-4-(2'-deoxy-.beta.-D-ribofuranosyl)benzo[d]naphtho[1,2-b]pyran-6-one. Synthetic C-glycosides related to the gilvocarcin, ravidomycin, and chrysomycin antibiotics (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT8-Ethenyl-1-hydroxy-4-.beta.-D-ribofuranosylbenzo[d]naphtho[1,2-b]pyran-6-one and 8-ethenyl-1-hydroxy-4-(2'-deoxy-.beta.-D-ribofuranosyl)benzo[d]naphtho[1,2-b]pyran-6-one. Synthetic C-glycosides related to the gilvocarcin, ravidomycin, and chrysomycin antibioticsRoger N. Farr, Daw Iong Kwok, and G. Doyle Daves Jr.Cite this: J. Org. Chem. 1992, 57, 7, 2093–2100Publication Date (Print):March 1, 1992Publication History Published online1 May 2002Published inissue 1 March 1992https://pubs.acs.org/doi/10.1021/jo00033a034https://doi.org/10.1021/jo00033a034research-articleACS PublicationsRequest reuse permissionsArticle Views520Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Structure of 6-azidotetrazolo[5,1-a]phthalazine, C8H4N8, isolated from the toxic dinoflaggelate Gymnodinium breve (1985)

Cristallisation dans PZ 1 Z 1 Z 1 avec Z=4 ; affinement jusqu'a R=0,035. Le systeme a trois cycles condenses est parfaitement plan. Longueurs et angles de liaison du cycle tetrazole et du groupe azoturo en bon accord avec ceux des structures apparentees
On the Importance of Mental Health in STEM (2023)

From homework to exams to proposal deadlines, STEM academia bears many stressors for students, faculty, and administrators. The increasing prevalence of burnout as an occupational phenomenon, along with anxiety, depression, and other mental illnesses in the STEM community is an alarming sign that help is needed. We describe common mental illnesses, identify risk factors, and outline symptoms. We intend to provide guidance on how some people can cope with stressors while also giving advice for those who wish to help their suffering friends, colleagues, or peers. We hope to spark more conversation about this important topic that may affect us all-while also encouraging those who suffer (or have suffered) to share their stories and serve as role models for those who feel they cannot speak.
Exploring the Evolution and Deformation of Twinned Nanocrystalline Metals with Microscale Kinematic Metrics and Molecular Dynamics Simulations. (2013)

Abstract not provided.
ji suan ji ruan jian gong cheng guan li yu ying yong jie xi (2015)

计算机软件工程是一项综合性、技术性、系统性的工作,对开发人员的要求较高,为确保开发工作的顺利实施,应对其进行有效管理,明确各人员的工作职责,树立风险意识,提高各部门人员之间的合作意识,保障计算机软件工程的顺利实施.本文对计算机软件工程的管理内容及管理措施进行了详细分析,并在此基础上对计算机软件的应用进行了简要介绍,希望能引发读者思考.
Genetic Determinations of Variable Responsiveness to Clopidogrel and Implications for Neurointerventional Procedures (2012)

Endovascular intervention is emerging as a substitute for open surgical procedures for the treatment of cerebrovascular disease. However, up to 9% of patients undergoing neurointerventional procedures develop thromboembolic complications. Strategies to reduce periprocedural thromboembolic events are dominated by the use of dual antiplatelet therapy (DAT) which has been validated based on studies of peripheral vascular and coronary intervention. Of note, DAT decreases adverse vascular outcomes by 75-80% in patients undergoing percutaneous coronary intervention (PCI). It follows that similar treatment effects would be observed in neurointerventional populations. However, a growing body of evidence demonstrates that a subgroup of patients respond suboptimally to DAT, and in particular to clopidogrel (termed clopidogrel hyporesponders). These patients may be at an increased risk of thromboembolic complications such as in-stent thrombosis following neurointerventional procedures. Previous studies report 5-30% suboptimal response to clopidogrel in the cardiovascular population, while a higher prevalence is seen in populations undergoing neurointerventional procedures, i.e. as much as 66%. Knowledge of the mechanism leading to clopidogrel hyporesponsiveness is accumulating. A number of genetic polymorphisms, in particular CYP 2C19*2, have been associated with clopidogrel hyporesponsiveness and clinical outcomes. In addition, there are significant differences in the prevalence of CYP 2C19*2 across racial groups. Approximately 50% of Asians and 25% of Caucasians harbor the CYP 2C19*2 allele. While no prospective randomized trials currently exist to demonstrate improved clinical outcomes with genotype-based treatment for carriers of the CYP 2C19*2 polymorphism, a number of studies show that an increased dose of clopidogrel improves platelet inhibition in hyporesponders. The aim of the review is to examine the current understanding of the genetic basis of clopidogrel hyporesponsiveness in patients undergoing neurointerventional procedures and to explore current efforts using genotype and phenotype testing as well as alternative strategies to overcome the clopidogrel hyporesponsiveness.
ELECTROMAGNETIC SHIELDING PERFORMANCES OF COLEMANITE / PANI / SIO2 COMPOSITES IN RADAR AND WIDER FREQUENCY RANGES (2020)

In this study, colemanite-SiO2 were produced by using mixed oxide technique. The composition was formed with various proportions for the structural analysis. The results of the structural analysis indicated that second phase did not form in colemanite and SiO2. Addionality, the colemanite/polyaniline/SiO2 composites were produced by hot pressing using the compositions of colemanite-SiO2 in different proportions and aniline. The weight ratios of colemanite-SiO2 and aniline were 1:1 respectively and epoxy resin was used to produce microwave shielding composites. The microwave shielding performances of colemanite/polyaniline/SiO2 composites were investigated by shielding effectiveness in 8 –18 GHz using two–port vector network analyzer. A minimum of – 41.1 dB shielding effectiveness performance was obtained in 16.09 GHz at the thickness of 1.5 mm. This shielding performance can be modulated simply by controlling the content of polyaniline and content of colemanite-SiO2 in the samples for the required frequency bands.
Purification and Properties of Human Urine Ribonuclueases (1981)

1. Two RNases (RNase UL and RNase US) were purified from the urine of human adults by means of column chromatographies on SP-Sephadex C-50, phospho-cellulose and CM-cellulose and gel-filtration on Sephadex G-75 in homogeneous states obtained by SDS-disc electrophoresis. 2. Molecular weights of these RNases determined by gel-filtration were 38,000 and 13,000 for RNase UL and RNase US, respectively. 3. Optimal pH's of urine RNases were 8.0 and 6.75 for RNase UL and RNase US, respectively. 4. Chemical composition of urine RNases was determined. RNase UL contains about 20.7% of neutral sugar and 7.8% of hexosamine. RNase US contains a very small amount of carbohydrate moiety. 5. Base specificity of urine RNases studied with 2',3'-cyclic nucleotides and dinucleoside phosphates as substrates indicated that both RNases were pyrimidine specific and cytosine preferential enzyme, as is bovine pancreatic RNase A. Although base specificity of RNase UL was qualitatively similar to RNase A, that of RNase US was slightly different. That is, RNase US did not hydrolyze UpU and hydrolyzed UpC and 2',3'-cyclic UMP very slowly. 6. Antigenic properties of human urine RNases were studied by Ouchterlony's double diffusion analysis. RNase UL, RNase US, and RNase A were serologically distinguishable.