gebhart/patrepeval huggingface dataset:
Hexadecapolar colloids (2016)

Outermost occupied electron shells of chemical elements can have symmetries resembling that of monopoles, dipoles, quadrupoles and octupoles corresponding to filled s-, p-, d- and f-orbitals. Theoretically, elements with hexadecapolar outer shells could also exist, but none of the known elements have filled g-orbitals. On the other hand, the research paradigm of 'colloidal atoms' displays complexity of particle behaviour exceeding that of atomic counterparts, which is driven by DNA functionalization, geometric shape and topology and weak external stimuli. Here we describe elastic hexadecapoles formed by polymer microspheres dispersed in a liquid crystal, a nematic fluid of orientationally ordered molecular rods. Because of conically degenerate boundary conditions, the solid microspheres locally perturb the alignment of the nematic host, inducing hexadecapolar distortions that drive anisotropic colloidal interactions. We uncover physical underpinnings of formation of colloidal elastic hexadecapoles and describe the ensuing bonding inaccessible to elastic dipoles, quadrupoles and other nematic colloids studied previously.
Evolution of phenotypic memory T cells in HIV-1 infected infants and children (1992)

Infants are reported to be devoid of memory T cells at birth but acquire them with time. A cross-sectional study of peripheral blood mononuclear cells from HIV-infected and uninfected infants and children that bear the CD4R0 anti-gen was undertaken to describe the development of memory T cells. Linear regression lines derived from the data revealed increasing percentages of memory CD4 and CD8 cells in the uninfected children. Memory CD4 cells in the infected children were detected at a frequency equal to or greater than that seen in uninfected children until 6 months of age but subsequently declined with age. In contrast, memory CD8 cells were found to be significantly increased in HIV-infected children early in life with a rate of increase similar to that seen in the uninfected population. This increase in memory CD8 cells may facilitate the early diagnosis of HIV infection.
Assessment of flow in the right human coronary artery by magnetic resonance phase contrast velocity measurement: Effects of cardiac and respiratory motion (1996)

Flow in the human right coronary artery was determined using magnetic resonance phase contrast velocity quantification. Two methods were applied to reduce respiratory motion: Imaging during breath holding, which is fast, and retrospective respiratory gating, which has a high temporal resolution (32 ms) in the cardiac cycle. Vessel cross-sectional area, through-plane velocity, and volume flow were determined in six healthy subjects. In-plane vessel displacement during the cardiac cycle, caused by cardiac contraction, was about 2-4 mm within a time frame of 32 ms in systole and early diastole. The motion resulted in blurring of images obtained during breath holding caused by the large acquisition time window (126 ms) within the cardiac cycle. Therefore, only with a high temporal resolution correct velocity images over the entire cardiac cycle could be obtained. The time- and cross-sectionally averaged velocity was 7 +/- 2 cm/s, and the volume flow was 30 +/- 10 ml/min.
Electrospun Nanofibers for Air Filtration Applications (2014)

Activated carbon and fiberglass are widely used in air filtration industry. Nanotechnology field is booming in an exceptionally impressive manner. Nanofibers are one of the unique materials which have one order of magnitude smaller than conventional fibers. The high surface-to-volume ratio, low resistance and enhanced filtration performance make nanofibers an attractive material for many applications such as healthcare, energy and air filtration. Recent advancements in the removal of volatile organic compounds (VOC), nanoparticles and airborne bacterial contaminates in the air are highlighted. The aerosol filtration performances of nanofibers are also presented. The enhanced activity of nanofibers due to the nanosize and their applications such as in protective clothing are highlighted.
PROTEOLYSIS OF HUMAN FIXED, WASHED PLATELETS BY GRAM‐NEGATIVE BACTERIAL METALLOPROTEASES: EFFECT ON von WILLEBRAND FACTOR‐HUMAN PLATELET INTERACTIONS* (1981)

Fixed, washed platelets (FWP) are usually stable to aggregation with von Willebrand factor (vWF) from human and certain animal plasmas over several months of storage. When one lot of FWP lost its stability in less than 1 week, studies demonstrated contamination with Serratia marcescens. Extracellular proteases produced by S. marcescens, as well as by Pseudomonas aeruginosa and Escherichia coli, were found to cause loss of FWP aggregability. Purified proteases were prepared from cell-free culture filtrates of S. marcescens and two different strains of P. aeruginosa. They were used to study the effect on the interaction of FWP and vWF. All three purified proteases destroyed FWP aggregability in a time- and concentration-dependent fashion. The protease produced by S. marcescens (SP) was found to be at least eight times more potent against FWP as a substrate than either of the two P. aeruginosa enzymes. The ability of SP to destroy FWP aggregability was prevented by EDTA and could be restored by the addition of Zn2+ in slight molar excess. When compared with trypsin and chymotrypsin, SP was found to be highly selective in digesting the FWP membrane, even at concentrations greater than that established to give a similar loss of FWP aggregability. SP does not induce aggregation of fresh, washed platelets or PRP, but renders them unaggregable with vWF. These proteases may be useful research tools for studying membranes and vWF-platelet interactions.
ShakeUnlock (2014)

The inherent weakness of typical mobile device unlocking approaches (PIN, password, graphic pattern) is that they demand time and attention, leading a majority of end users to disable them, effectively lowering device security.
Virus-specific memory T cells populate tumors and can be repurposed as a tumor immunotherapy (2019)

Abstract The immunosuppressive tumor microenvironment limits the success of current immunotherapies. The host retains memory T cells specific for previous infections throughout the entire body that are capable of executing potent and immediate immunostimulatory functions. Here we show that virus-specific memory T cells extend their surveillance to mouse and human tumors. Reactivating these antiviral T cells can arrest growth of checkpoint blockade-resistant and poorly immunogenic tumors in mice after injecting adjuvant-free non-replicating viral peptides into tumors. Peptide mimics a viral reinfection event to memory CD8+ T cells, triggering antigen presentation and cytotoxic pathways within the tumor, activating dendritic cells and natural killer cells, and recruiting the adaptive immune system. Viral peptide treatment of ex vivo human tumors recapitulates immune activation gene expression profiles observed in mice. Lastly, peptide therapy renders resistant mouse tumors susceptible to PD-L1 blockade. Thus, re-stimulating known antiviral immunity may provide a unique therapeutic approach for cancer immunotherapy.
FGF-1: a human growth factor in the induction of neoangiogenesis (1998)

Currently available approaches for treating human coronary heart disease aim to relieve symptoms and the risk of myocardial infarction either by reducing myocardial oxygen demand, preventing further disease progression, restoring coronary blood flow pharmacologically or mechanically, or bypassing the stenotic lesions and obstructed coronary artery segments. Gene therapy, especially using angiogenic growth factors, has emerged recently as a potential new treatment for cardiovascular disease. Following extensive experimental research on angiogenic growth factors, the first clinical studies on patients with coronary heart disease and peripheral vascular lesions have been performed. The polypeptides fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF) appear to be particularly effective in initiating neovascularisation (neo-angiogenesis) in hypoxic or ischaemic tissues. The first clinical study on patients with coronary heart disease treated by local intramyocardial injection of FGF-1 showed a 3-fold increase of capillary density mediated by the growth factor. Angiogenic therapy of the human myocardium introduces a new modality of treatment for coronary heart disease in terms of regulation of blood vessel growth. Beyond drug therapy, angioplasty and bypass surgery, this new approach may evolve into a fourth principle of treatment of atherosclerotic cardiovascular disease.
<title>Airborne testing of the joint mine detection technology's tunable filter multispectral camera</title> (2002)

The Joint Mine Detection Technology (JMDT) project, following successful field-based testing of its new Tunable Filter Multispectral Camera (TFMC) has now completed initial Airborne Testing of the TFMC at both the Coastal Systems Station and Eglin Air Force Base sites. An overview of the testing is presented along with the investigations into the advantages of a system utilizing the TFMC in airborne operational scenarios. The TFMC-like tuning flexibility was flight-tested using optimized wavelength combinations, which were found using field test data, over a variety of backgrounds and altitudes. The data revealed the suitability of background tuning, polarization, and mechanically co-registered channels as benefits to multispectral target detection. The data were also compared to that collected with an IMC-201 camera, using the six filters of the Coastal Battlefield Reconnaissance and Analysis (COBRA) Advanced Technology Demonstration (ATD) system, in order to determine improvements over existing capabilities.
Monocytes harbour replication-competent, non-latent HIV-1 in patients on highly active antiretroviral therapy (2001)

Recovery of replication-competent virus from some HAART patients indicates that monocytes can also harbour HIV-1. Detection of circular, viral DNA and spliced RNA, albeit at very low levels, in these cells suggests that their infection is recent and transcriptionally active rather than latent.
Phase Tuning for Enhancing the Thermoelectric Performance of Solution-Synthesized Cu2–xS (2021)

Cu<sub>2</sub>S, consisting of Earth-abundant and eco-friendly elements, is a promising candidate for thermoelectric energy conversion. The stoichiometric Cu<sub>2</sub>S has intrinsically low thermal conductivity together with meagre electrical conductivity. Herein, in order to improve the electrical properties, we develop a facile solvothermal method for synthesizing a series of Cu<sub>2-<i>x</i></sub>S with tunable phase compositions. With reduction in the CuCl/Na<sub>2</sub>S molar ratio in the solution precursors from 2:1 to 1.75:1, the solvothermal products transform from single-phase Cu<sub>2</sub>S into Cu<sub>2</sub>S-Cu<sub>1.96</sub>S composites, which are preserved in the hot-pressed pellets. The decreased CuCl/Na<sub>2</sub>S molar ratio results in increased room-temperature Hall carrier concentration, leading to enhanced electrical conductivity. Specifically, the pellet corresponding to the 1.75:1 CuCl/Na<sub>2</sub>S precursor ratio obtains a power factor of 8.04 μW cm<sup>-1</sup> K<sup>-2</sup> at 815 K, which is ∼735% of the value obtained by stoichiometric Cu<sub>2</sub>S. Along with the moderate thermal conductivity, this sample achieves an enhanced <i>zT</i> value of 0.87 at 815 K, representing a ∼250% increase when compared to stoichiometric Cu<sub>2</sub>S. This study demonstrates an effective strategy in enhancing the thermoelectric performance of solution-synthesized Cu<sub>2</sub>S-based materials by phase tuning.
3D FACE RECOGNITION FROM RANGE IMAGES BASED ON CURVATURE ANALYSIS (2014)

ICTACT Journals are peer reviewed International Journals published quarterly. With the objective of creating Indian-based Journals of International quality and to build up local research content, ICTACT Journals exists for the purpose of providing a quality peer-reviewed platform for Scientists, Researchers, Academicians and Engineers who carry out their original research. The Journals will highlight the continued growth and new challenges in both basic research and application development.
BSIM3 parameters extraction of a 0.35 μm CMOS technology from 300K down to 77K (2017)

International audience
Impact of Antenna Tilting on Propagation Shadowing Model (2013)

With active antenna systems (AAS) cell deployment changes can be handled rather flexible to meet the local and momentary capacity demands. Antenna tilt is one of the important parameters that should be properly adjusted in order to enhance the performance and efficiency of a cellular network. Simulative performance evaluation of these gains currently assumes radio propagation models where the shadowing map remains unchanged with respect to tilt changes. The assumption, however, may not be ralistic in particular to dense urban and urban scenarios. This paper investigates the impact of tilt on the shadowing map with regard to the current 3GPP assumptions. Moreover, the work tries to check if the shadowing process can be really assumed as stationary and independent from beam changes. The investigations are based on shadowing maps isolated from real world ray tracing propagation maps and has been carried out for urban scenario with various beam tilt settings.
T2* relaxometry to characterize normal placental development over gestation in-vivo at 3T (2019)

<ns4:p> <ns4:bold>Background:</ns4:bold> T2* relaxometry has been identified as a non-invasive way to study the placenta in-vivo with good potential to identify placental insufficiency. Typical interpretation links T2* values to oxygen concentrations. This study aimed to comprehensively assess T2* maps as a marker of placental oxygenation <ns4:italic>in-vivo</ns4:italic> . </ns4:p> <ns4:p> <ns4:bold>Methods</ns4:bold> : A multi-echo gradient echo echo planar imaging sequence is used in a cohort of 84 healthy pregnant women. Special emphasis is put on spatial analysis: histogram measures, Histogram Asymmetry Measure (HAM) and lacunarity. Influences of maternal, fetal and placental factors and experimental parameters on the proposed measures are evaluated. </ns4:p> <ns4:p> <ns4:bold>Results</ns4:bold> : T2* maps were obtained from each placenta in less than 30sec. The previously reported decreasing trend in mean T2* with gestation was confirmed (3.45 ms decline per week). Factors such as maternal age, BMI, fetal sex, parity, mode of delivery and placental location were shown to be uncorrelated with T2* once corrected for gestational age. Robustness of the obtained values with regard to variation in segmentation and voxel-size were established. The proposed spatially resolved measures reveal a change in T2* in late gestation. </ns4:p> <ns4:p> <ns4:bold>Conclusions</ns4:bold> : T2* mapping is a robust and quick technique allowing quantification of both whole volume and spatial quantification largely independent of confounding factors. </ns4:p>
An integrated approach for multilane robot motion planning using motor schema and fuzzy logic (2005)

This paper presents a novel multilane-based approach that integrates global and local path planning of mobile robots. It employs motor schema-based behavior coordination with fuzzy logic-based adaptive behavioral modulation. Voronoi diagram and A* search algorithm are exploited to determine the global safe-path and subgoals between the starting point of the robot and target. Safe lanes are formed around the safe-path. The robot locally optimizes the path length using a cost function for on-line selection of obstacle-free safe lane. Motor schema based behavior fusion is used for on-line coordination of force vectors originated from the subgoal, safe path and obstacles to generate the safe heading direction. A supervisory fuzzy module is developed to dynamically produce the force coefficients for context dependent modulation of the virtual forces. Adapted vector field histogram is deployed in order to modify the safe path in the presence of unknown obstacles. Simulation of navigation examples validates the performance of the algorithm.
The transduction pattern of IL‐12‐encoding lentiviral vectors shapes the immunological outcome (2015)

In situ modification of antigen-presenting cells garnered interest in cancer immunotherapy. Therefore, we developed APC-targeted lentiviral vectors (LVs). Unexpectedly, these LVs were inferior vaccines to broad tropism LVs. Since IL-12 is a potent mediator of antitumor immunity, we evaluated whether this proinflammatory cytokine could enhance antitumor immunity of an APC-targeted LV-based vaccine. Therefore, we compared subcutaneous administration of broad tropism LVs (VSV-G-LV) with APC-targeted LVs (DC2.1-LV)-encoding enhanced GFP and ovalbumin, or IL-12 and ovalbumin in mice. We show that codelivery of IL-12 by VSV-G-LVs or DC2.1-LVs augments CD4(+) or CD8(+) T-cell proliferation, respectively. Furthermore, we demonstrate that codelivery of IL-12 enhances the CD4(+) TH 1 profile irrespective of its delivery mode, while an increase in cytotoxic and therapeutic CD8(+) T cells was only induced upon VSV-G-LV injection. While codelivery of IL-12 by DC2.1-LVs did not enhance CD8(+) T-cell performance, it increased expression of inhibitory checkpoint markers Lag3, Tim3, and PD-1. Finally, the discrepancy between CD4(+) T-cell stimulation with and without functional CD8(+) T-cell stimulation by VSV-G- and DC2.1-LVs is partly explained by the observation that IL-12 relieves CD8(+) T cells from CD4(+) T-cell help, implying that a T(H)1 profile is of minor importance for antitumor immunotherapy if IL-12 is exogenously delivered.
Relation between Growth Rate, Serum Somatomedin and Plasma Testosterone in Young Bulls (1977)

Twenty “Red Danish” bulls were tested for rate of gain, linear growth, longissimus muscle area and efficiency of feed utilization from the age of 1½ to 12 months. These variables were correlated to blood concentrations of testosterone and somatomedin, which were measured at 4 to 5 months, 6 to 7 months and/or 8 to 10 months of age. Average testosterone concentrations of bulls above 6 months of age were found to be correlated negatively (P<.05) with feed utilization (feed units/kg gain). Average somatomedin activities throughout the test period were positively correlated with rate of gain (P<.05) and linear growth (P<.05), and negatively to feed utilization (P<.05). Also, the somatomedin activity was found to increase significantly from 6 to 7 months up to 10 months of age (P<.05). No significant correlation between testosterone and rate of gain, linear growth or longissimus muscle area was found, and, likewise, there was no significant correlation between somatomedin activity and longissimus muscle area. It is concluded that the blood level of somatomedin at an early age may represent a possible indicator of future growth capacity in young bulls.
Reaction mechanisms of Trp120.fwdarw.Phe and wild-type glucoamylases from Aspergillus niger. Interactions with maltooligodextrins and acarbose (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReaction mechanisms of Trp120.fwdarw.Phe and wild-type glucoamylases from Aspergillus niger. Interactions with maltooligodextrins and acarboseKarsten Olsen, Ulla Christensen, Michael R. Sierks, and Birte SvenssonCite this: Biochemistry 1993, 32, 37, 9686–9693Publication Date (Print):September 21, 1993Publication History Published online1 May 2002Published inissue 21 September 1993https://pubs.acs.org/doi/10.1021/bi00088a021https://doi.org/10.1021/bi00088a021research-articleACS PublicationsRequest reuse permissionsArticle Views124Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
New Moon in January (2008)

Journal Article New Moon in January Get access Paul Breslin Paul Breslin p-breslin@northwestern.edu Search for other works by this author on: Oxford Academic Google Scholar Literary Imagination, Volume 11, Issue 1, 2009, Page 124, https://doi.org/10.1093/litimag/imn040 Published: 10 July 2008
Alveolar proteins stabilize cortical microtubules in Toxoplasma gondii (2019)

Abstract Single-celled protists use elaborate cytoskeletal structures, including arrays of microtubules at the cell periphery, to maintain polarity and rigidity. The obligate intracellular parasite Toxoplasma gondii has unusually stable cortical microtubules beneath the alveoli, a network of flattened membrane vesicles that subtends the plasmalemma. However, anchoring of microtubules along alveolar membranes is not understood. Here, we show that GAPM1a, an integral membrane protein of the alveoli, plays a role in maintaining microtubule stability. Degradation of GAPM1a causes cortical microtubule disorganisation and subsequent depolymerisation. These changes in the cytoskeleton lead to parasites becoming shorter and rounder, which is accompanied by a decrease in cellular volume. Extended GAPM1a depletion leads to severe defects in division, reminiscent of the effect of disrupting other alveolar proteins. We suggest that GAPM proteins link the cortical microtubules to the alveoli and are required to maintain the shape and rigidity of apicomplexan zoites.
Impacts of mobility on telecommunication and data communication networks (1995)

The article gives an overview of architectures and service aspects of existing networks and of those under development, with a special focus on mobility support. The authors discuss relations and differences of concepts being rooted in data communications and telecommunications, respectively, while paying special attention to the future role of the ISO/OSI reference model. They have subdivided the discussion based on different network classes with different degrees of mobility support; starting with fixed networks and finishing with networks enabling unlimited mobility of users and terminals. Finally, they describe the impact of unlimited terminal mobility on next generation communication networks.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>