gebhart/patrepeval huggingface dataset:
RETRACTED: Evidence for a functional role of IgE anticitrullinated protein antibodies in rheumatoid arthritis (2010)

Rheumatoid arthritis (RA) is a systemic autoimmune disease involving inflammation of the joints. Among the autoantibodies described in RA, anticitrullinated protein antibodies (ACPAs) are highly specific and predictive for RA. In addition, ACPAs have been implicated in the pathogenesis of RA. However, a direct functional response of immune cells from ACPA(+) RA patients toward citrullinated proteins has not been demonstrated. In this study, we show that exposure to citrullinated antigens leads to activation of basophils from ACPA(+) RA patients within 20 minutes. This was not observed after exposure of basophils to noncitrullinated control antigens or after stimulation of basophils from ACPA(-) RA patients and healthy controls. Basophil activation was correlated with the binding of citrullinated proteins to basophils. Furthermore, serum from ACPA(+) RA patients in contrast to that from ACPA(-) RA patients could specifically sensitize human FcepsilonRI expressing rat basophil cells (RBL), enabling activation by citrullinated proteins. Mast cell degranulation products such as histamine levels were enhanced in synovial fluid of ACPA(+) RA patients as compared with ACPA(-) RA and osteoarthritis patients. In addition, histamine levels in synovial fluid from ACPA(+) RA patients correlated with IgE levels, suggesting degranulation of mast cells by cross-linking IgE. Immunohistochemistry on synovial biopsies demonstrated an increased number of degranulated CD117(+) mast cells in ACPA(+) RA patients; IgE and FcepsilonRI expression in synovial mast cells from ACPA(+) RA patients was increased. In conclusion, our results show an immunological response of immune cells from ACPA(+) RA patients in a citrulline-specific manner. Moreover, these data indicate a role for IgE-ACPAs and FcepsilonRI-positive cells in the pathogenesis of RA.
Chain Orientation in Block Copolymers Exhibiting Cylindrically Confined Crystallization (1998)

The orientation of the crystal stems in diblock copolymers, where crystallization occurs within the cylindrical microdomains present in the melt mesophase, is investigated via X-ray scattering on flow-aligned specimens. A series of ethylene-b-(3-methyl-1-butene) diblocks (E/MB) is compared with an ethylene-b-(vinylcyclohexane) diblock (E/VCH), where MB is rubbery (Tg < Troom) and VCH is vitreous (Tg = 134 degreesC) at the freezing point of the E block. All of the diblocks contain 26-28 wt % E, leading to a morphology of hexagonally-packed E cylinders. Crystallization in all of these materials can be confined to the cylindrical microdomains. Not only do the crystals align preferentially within the semicrystalline cylinders, but this orientation varies depending on the ability of chains to diffuse during the crystallization process. When chain diffusion is most rapid, alignment is observed with the chain axis in the crystals perpendicular to the cylinder axis and the b axis (fast growth axis) coincident with the cylinder axis. However, when the chain mobility is limited, the crystal stems tilt with respect to a plane which is normal to the cylinder axis, allowing better accommodation of amorphous material at the crystallite surface.
Stem Cells Helping Reproductive Medicine (2013)

The stem cell field, with its ups and downs, owes much to the work by clinicians, embryologists, and researchers working in reproductive medicine. It seems that the time is fast approaching when all of our careful investment in this field will finally come to fruition. This issue of Seminars in Reproductive Medicine presents both real and potential breakthroughs in reproductive medicine based on translational stem cell research. Its special value is derived from the inclusion of outstanding work from the most relevant internationally recognized experts working in this hybrid field today.
Effect of Training on Visual Identification of High Frequency Oscillations—A Delphi-Style Intervention (2022)

This study shows a robust effect of a Delphi-style intervention on the interrater variability, reliability, and generalizability of HFO evaluations. The observed decreases in HFO marking discrepancies across 14 of the 15 reviewers are encouraging: they are necessarily associated with an increase in interrater reliability, and therefore with a corresponding decrease in the number of reviewers required to achieve strong generalizability. Indeed, the reliability of all reviewers following the intervention was similar to that of experienced reviewers prior to intervention. Therefore, a Delphi-style intervention could be implemented either to sufficiently train any reviewer, or to further refine the interrater reliability of experienced reviewers. In either case, a Delphi-style intervention would help facilitate the standardization of HFO evaluations and its implementation in clinical care.
Prevalence and Diversity of Microbes in the Amniotic Fluid, the Fetal Inflammatory Response, and Pregnancy Outcome in Women with Preterm Pre‐Labor Rupture of Membranes (2010)

MIAC in pPROM is more common than previously recognized and is associated in some cases with uncultivated taxa, some of which are typically associated with the gastrointestinal tract. The detection of MIAC by molecular methods has clinical significance.
Cycling Performance of NMC811 Anode-Free Pouch Cells with 65 Different Electrolyte Formulations (2021)

Liquid electrolytes for anode-free Li metal batteries (LMBs) provide a cost-effective path to high energy density. However, liquid electrolytes are challenging due to the reactivity of Li 0 with the electrolyte and the resulting Li loss, as well as mossy Li deposits leading to inactive Li and dendrite formation. Thus, more research is needed to develop electrolytes capable of 80 % capacity retention after 800 cycles to meet electric vehicle (EV) demands. Here, we report cycle life results from 65 electrolyte mixtures consisting of various additives or co-solvents added to a dual-salt base electrolyte previously reported by our group. We tested these electrolyte systems using a practical anode-free pouch cell design with a high-loading (16 mg cm −2 , or 3.47 mAh cm -2 ) LiNi 0.8 Mn 0.1 Co 0.1 O 2 (NMC811) cathode, with a bare Cu foil as the counter electrode. All cells in this work were cycled at 40 °C with 0.2C/0.5C charge/discharge rates between 3.55–4.40 V. Based on the total energy delivered over 140 cycles, only four electrolytes showed marginal improvement over the baseline, while the other electrolytes were uncompetitive. This data set can serve as a guide for LMB researchers investigating electrolyte systems and highlights the challenges associated with liquid electrolytes.
Radiation beam with a large tilt angle (2016)

The wide beam radiated in the broadside direction from a patch antenna is transformed into a narrow tilted beam using three loop-based plates. The loops are made of strip conductors and have the same outer circumference and different strip widths. A tilted beam of approximately 60 degrees from the broadside direction is realized. A VSWR bandwidth of 8% is obtained.
Mycobacterium avium interaction with macrophages and intestinal epithelial cells (1999)

Mycobacterium avium is an environmental microorganism that is adapted to live both in the environment (mainly in water and soil) and in bird, fish and mammal hosts. In humans, M. avium infection is seen in patients with some sort of immunosuppression, such as patients with chronic lung disease, and Acquired Immunodeficiency Syndrome. More recently, other populations were shown to be at risk to develop M. avium disease. For the majority of time, humans acquire M. avium through the intestinal tract where the bacterium comes in contact with and translocates the intestinal mucosa. M. avium possesses a unique manner to interact with the intestinal mucosa, and, following invasion, can enter and survive within macrophages and monocytes. Although in vitro entry seems to be dependent on binding to the complement receptor, this finding has not been observed in vivo where the bacterium appears to enter macrophages by alternative mechanisms. The bacterium appears to trigger little inflammatory response, and is able to adapt itself to different environments in the host.
Binding of N -Substituted Erythromycylamines to Ribosomes (1976)

Several N -substituted erythromycylamines were evaluated for their ability to inhibit the binding of [ 14 C]erythromycin to ribosomes. The association and dissociation constants for the binding of each compound to Escherichia coli ribosomes were determined. These studies have resulted in the development of three types of probes for topological studies of the erythromycin-binding site and the ribosome: the chemically reactive bromoacetamido, the photoreactive N -(2)-nitro-4-azidophenyl)glycinamido, and the fluorescent fluorescein isothiocyanate derivatives of 9(S)-erythromycylamine.
Ruthenium‐Catalyzed Isomerization of Oxa/Azabicyclic Alkenes: An Expedient Route for the Synthesis of 1,2‐Naphthalene Oxides and Imines. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Polymeric Adsorption of Methylene Blue in TiO2 Colloids—Highly Sensitive Thermochromism and Selective Photocatalysis (2012)

The polymeric adsorption of methylene blue (MB) on a TiO(2) surface is reported. The MB molecule on the TiO(2) surface mainly exists as the H-trimeric adsorption state, which results in the MB@TiO(2) polymeric sol. The trimeric adsorption leads to a remarkable "blueshift" of visible-light adsorption of MB. Electrostatic attraction is important for trimeric adsorption of MB on TiO(2) surfaces. The trimer-monomer equilibrium is highly sensitive on temperature changes, showing an interesting reversible thermochromism. The MB@TiO(2) polymeric sol can be photodegraded under UV illumination without destroying the equilibrium of trimer-monomer. Compared with anionic methyl orange, the TiO(2) colloid hydrosol shows highly selective photocatalysis of MB and other cationic dyes, including crystal violet, methylene green, and victoria blue B. The MB@TiO(2) polymeric sol is stable under visible-light illumination because interfacial transfer of electrons does not exist between MB and TiO(2).
RPF: a quality assessment tool for protein NMR structures (2012)

We describe the RPF web server, a quality assessment tool for protein NMR structures. The RPF server measures the 'goodness-of-fit' of the 3D structure with NMR chemical shift and unassigned NOESY data, and calculates a discrimination power (DP) score, which estimates the differences between the fits of the query structures and random coil structures to these experimental data. The DP-score is an accuracy predictor of the query structure. The RPF server also maps local structure quality measures onto the 3D structure using an online molecular viewer, and onto the NMR spectra, allowing refinement of the structure and/or NOESY peak list data. The RPF server is available at: http://nmr.cabm.rutgers.edu/rpf.
Global asymptotic stabilisation of non-linear systems (2008)

In this article, the problem of global asymptotic stabilisation of non-linear systems is considered. First of all, the global asymptotic stability of a class of non-linear systems is considered. It is proved that the class of non-linear systems is globally asymptotically stable under certain appropriate conditions. Secondly, based on the result obtained, the global asymptotic stabilisation of a class of non-linear systems is investigated, and the feedback control laws, which globally stabilise the class of systems, are designed. Thirdly, by the coordinate change and the results obtained, the global stabilisation of the affine non-linear systems are studied, and then some sufficient conditions of stabilisation are presented. Finally, the global asymptotic stabilisation of partially linear cascade non-linear system is considered. The sufficient conditions of global stabilisation are obtained, and the corresponding feedback control laws, which stabilise the non-linear systems, are designed. In addition, some examples are given to show the effectiveness of the new results.
Dynamics of DNA translocation through an attractive nanopore (2008)

We investigate the dynamics of single-stranded DNA translocation through a nanopore driven by an external force using Langevin dynamics simulations in two dimensions to study how the translocation dynamics depend on the details of the DNA sequences. We consider a coarse-grained model of DNA built from two bases A and C, having different base-pore interactions, e.g., a strong (weak) attractive force between the pore and the base A (C) inside the pore. From a series of studies on hetero-DNAs with repeat units AmCn, we find that the translocation time decreases exponentially as a function of the volume fraction fC of the base C. For longer A sequences with fC<or=0.5, the translocation time strongly depends on the orientation of DNA, namely which base enters the pore first. Our studies clearly demonstrate that for a DNA of certain length N with repeat units AmCn, the pattern exhibited by the waiting times of the individual bases and their periodicity can unambiguously determine the values of m, n, and N, respectively. Therefore, a prospective experimental realization of this phenomenon may lead to fast and efficient sequence detection.
Data Communications for Engineers (1996)

From the Publisher:
Features
emphasises engineering aspects of communications rather than specific issues relating to the uses of data communication networks covers in detail the lower layers of the OSI model includes a thorough description of coding - source, channel and line discusses the various standards bodies which exist and their standards and recommendations includes many worked problems designed to improve the understanding of key principles
NMR quantum information processing and entanglement (2002)

In this essay we discuss the issue of quantum information and recent nuclear magnetic resonance (NMR) experiments. We explain why these experiments should be regarded as quantum information processing (QIP) despite the fact that, in present liquid state NMR experiments, no entanglement is found. We comment on how these experiments contribute to the future of QIP and include a brief discussion on the origin of the power of quantum computers.
Supplementary Tables 1-3 from Pancreatic Cancer Risk and ABO Blood Group Alleles: Results from the Pancreatic Cancer Cohort Consortium (2023)

Supplementary Tables 1-3 from Pancreatic Cancer Risk and ABO Blood Group Alleles: Results from the Pancreatic Cancer Cohort Consortium
Reactions with Nitriles: A Novel Synthesis of Furo[2,3-c]pyrazoles and Pyrano[2,3-c]pyrazoles (1984)

d i l y a v a i l a b l e 3-methyl-4-bromo-2-pyrazolin-Eone (3).
Ein genauerer Blick auf das Zusammenspiel von Lichtsammlung und Ladungstrennung in der Photosynthese (2014)

Neben dem einzigartigen Reaktionszentrum benötigt die organismische Photosynthese ein zusätzliches System lichtsammelnder Cofaktoren, die Photonenenergie durch strahlungslosen Resonanztransfer zu vereinzelten Aktivzentren der Ladungstrennung ableiten. Die Kristallstruktur eines Komplexes aus einem bakteriellen Reaktionszentrum mit Lichtsammelkomplex I zeigt nun im Detail, wie der Speicherring mit dem Zentrum der Ladungstrennung interagiert.
Severe antibody-mediated transfusion-related acute lung injury in an obstetric patient following transfusion of fresh frozen plasma from a non-transfused male blood donor (2020)

Transfusion Related Acute Lung Injury (TRALI) has been associated with neutrophil reacting antibodies in transfused blood products. We report a case of life threatening TRALI in an obstetric patient triggered by transfusion from a non-transfused male blood donor. A residual risk of TRALI exist, even in a male-only plasma setting.
GluN2B-containing NMDA receptors regulate depression-like behavior and are critical for the rapid antidepressant actions of ketamine (2014)

A single, low dose of the NMDA receptor antagonist ketamine produces rapid antidepressant actions in treatment-resistant depressed patients. Understanding the cellular mechanisms underlying this will lead to new therapies for treating major depression. NMDARs are heteromultimeric complexes formed through association of two GluN1 and two GluN2 subunits. We show that in vivo deletion of GluN2B, only from principal cortical neurons, mimics and occludes ketamine's actions on depression-like behavior and excitatory synaptic transmission. Furthermore, ketamine-induced increases in mTOR activation and synaptic protein synthesis were mimicked and occluded in 2BΔCtx mice. We show here that cortical GluN2B-containing NMDARs are uniquely activated by ambient glutamate to regulate levels of excitatory synaptic transmission. Together these data predict a novel cellular mechanism that explains ketamine's rapid antidepressant actions. In this model, basal glutamatergic neurotransmission sensed by cortical GluN2B-containing NMDARs regulates excitatory synaptic strength in PFC determining basal levels of depression-like behavior.
Parkinsons Disease-related Circulating microRNA Biomarkers——a Validation Study (2015)

Parkinson's disease (PD) is the second most common neurodegenerative disease. One of the major challenges in studying this progressive neurological disorder is to identify and develop biomarkers for early detection. Recently, several blood-based microRNA (miRNA) biomarkers for PD have been reported. However, follow-up studies with new, independent cohorts have been rare. Previously, we identified a panel of four circulating miRNA biomarkers for PD (miR-1826, miR-450b-3p, miR-505, and miR-626) with biomarker performance of 91% sensitivity and 100% specificity. However, the expression of miR-450b-3p could not be detected in a new, independent validation set. In our current study, we improved the detection power by including a non-biased pre-amplification step in quantitative real-time PCR (qRT-PCR) and reevaluated the biomarker performance. We found the panel of four PD-related miRNAs achieved the predictive power of 83% sensitivity and 75% specificity in our validation set. This is the first biomarker validation study of PD which showed reproducibility and robustness of plasma-based circulating miRNAs as molecular biomarkers and qRT-PCR as potential diagnostic assay.
Bidirectional regulation of renal hemodynamics by activation of PAR1and PAR2in isolated perfused rat kidney (2003)

Proteinase-activated receptors (PARs) are activated by either serine proteinases or synthetic peptides corresponding to the NH2-terminal tethered ligand sequences that are unmasked by proteolytic cleavage. Although PARs are highly expressed in the kidney, their roles in regulating renal function are not known. In the present study, we evaluated the impact of PAR activation on renal hemodynamics using PAR1- and PAR2-activating peptides (TFLLR-NH2 and SLIGRL-NH2) and proteinases (thrombin and trypsin) as PAR agonists in the isolated perfused rat kidney preparation. PAR1 activation resulted in renal vasoconstriction and a marked reduction in the glomerular filtration rate (GFR). In contrast, PAR2 activation caused vasodilation, partially reversing the vasoconstriction induced by TFLLR-NH2 and ANG II and increasing GFR that had been prereduced by ANG II. The vasoconstrictor actions of PAR1 activation were abolished by protein kinase C inhibition. The PAR2-induced vasodilation was only partially blocked by NG-nitro-l-arginine methyl ester, suggesting both nitric oxide-dependent and -independent mechanisms. Although PAR4 mRNA was detected in renal parenchyma, the PAR4-activating peptide AYPGKF-NH2 had no effect on renal perfusion flow rate. We conclude that PAR1 and PAR2 play bidirectional roles in the regulation of renal hemodynamics.
Analgesic narcotic antagonists. 3. Preparation of 7.beta.-methyldihydrothebaine-.vphi. (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAnalgesic narcotic antagonists. 3. Preparation of 7.beta.-methyldihydrothebaine-.vphi.David L. Leland, Joseph O. Polazzi, and Michael P. KotickCite this: J. Org. Chem. 1980, 45, 20, 4026–4028Publication Date (Print):September 1, 1980Publication History Published online1 May 2002Published inissue 1 September 1980https://pubs.acs.org/doi/10.1021/jo01308a016https://doi.org/10.1021/jo01308a016research-articleACS PublicationsRequest reuse permissionsArticle Views60Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Multiplying action of the magnetoresistance effect in semiconductors and its application to power measurements (1964)

The paper describes, in theory and practice, a new method of power measurement applicable over a wide frequency range, employing the magnetoresistance effect in an intermetallic semiconductor biased at a relatively high magnetic flux density.A theory has been developed for the multiplying action of the magnetoresistance effect compared with that of the Hall effect. It is shown that the multiplication sensitivity should be practically the same for both effects if the semiconductor element is the same in each case. However, the theory predicts that the sensitivity could be enhanced several times if the magnetoresistance element were suitably designed. Practical arrangements of applying the effect to power measurements are also discussed.Experiments have been carried out on the multiplication characteristics of the effect with InAs and InSb crystals, and satisfactory agreement with the theory has been obtained. Application to power measurements has been demonstrated for d.c. and a.c., and at microwave frequencies; the temperature dependence, and influence of power factor and of instability in the magnetic bias, were also investigated.The results showed excellent performance not only in linearity but also in voltage gain, with some advantages over the Hall effect.
ChemInform Abstract: Expeditious Route to F Unit Building Block of Moenomycin A. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.