gebhart/patrepeval huggingface dataset:
INFLUENCE OF POLYMER SHEAR THINNING ON FRICTION IN HYDRODYNAMIC CONTACTS (2014)

In order to understand (and ultimately to predict) the friction reduction resulting from the use of polymer solutions, the rheological properties of model polymer solutions have been measured over a wide range of shear rates. Both temporary and permanent shear thinning have been observed. By using base fluids of different viscosities it has been shown that permanent shear thinning depends more closely on the shear stress experienced by the fluid than on the strain rate. Hydrodynamic measurements have been made on the polymer solutions using a compliant ball on flat lubricated contact that operates in isoviscous-elastic conditions. The measured friction values can only be predicted with reasonable accuracy if the measured shear thinning properties of the lubricant are taken into account in the hydrodynamic model.
Verteilung: Armutsgefährdete Kinder und Schulabbrüche im regionalen Vergleich (2016)

Berechnungen des IW Köln zeigen, dass es in Regionen mit vielen armutsgefährdeten Kindern auch häufiger zu Schulabbrüchen kommt. Die Armutsgefährdung geht dabei häufig mit geringerer Bildung der Eltern einher. Damit sich durch Vererbung von Bildungsarmut die Armutsgefährdung in betroffenen Regionen nicht verfestigt, sollten flächendeckend qualitativ hochwertige Betreuungs- und Ganztagschulangebote gemacht werden.
Reactions of transition-metal .sigma.-acetylide complexes. 1. The reaction between W(C2Ph)(CO)3(.eta.-C5H5) and tetracyanoethylene: x-ray structure of W(CO)2[.eta.3-C(CN)CPhC:C(CN)2](.eta.-C5H5).cntdot.0.5C2(CN)4 (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactions of transition-metal .sigma.-acetylide complexes. 1. The reaction between W(C2Ph)(CO)3(.eta.-C5H5) and tetracyanoethylene: x-ray structure of W(CO)2[.eta.3-C(CN)CPhC:C(CN)2](.eta.-C5H5).cntdot.0.5C2(CN)4Michael I. Bruce, Trevor W. Hambley, Michael R. Snow, and A. Geoffrey SwincerCite this: Organometallics 1985, 4, 3, 494–500Publication Date (Print):March 1, 1985Publication History Published online1 May 2002Published inissue 1 March 1985https://pubs.acs.org/doi/10.1021/om00122a011https://doi.org/10.1021/om00122a011research-articleACS PublicationsRequest reuse permissionsArticle Views149Altmetric-Citations66LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Session 9 Overview: ML Processors From Cloud to Edge (2021)

Significant progress has been made in machine learning processor design in two different but important topic areas. The first addresses flexible accelerators for inference and training in the most advanced CMOS technology nodes (e.g. 5nm and 7nm) for mobile and the cloud. The second topic area covers application-specific acceleration engines for ultra-low-power applications, including wearable devices. This session comprises nine papers, covering a diverse set of neural networks targeted at a wide range of applications, including gesture recognition, smart cameras, speech-to-text and keyword spotting.
Signs of innate immune activation and premature immunosenescence in psoriasis patients (2017)

Psoriasis is a chronic inflammatory disease that affects skin and is associated with systemic inflammation and many serious comorbidities ranging from metabolic syndrome to cancer. Important discoveries about psoriasis pathogenesis have enabled the development of effective biological treatments blocking the T helper 17 pathway. However, it has not been settled whether psoriasis is a T cell-mediated autoimmune disease or an autoinflammatory disorder that is driven by exaggerated innate immune signalling. Our comparative gene expression and hierarchical cluster analysis reveal important gene circuits involving innate receptors. Innate immune activation is indicated by increased absent in melanoma 2 (AIM2) inflammasome gene expression and active caspase 1 staining in psoriatic lesional skin. Increased eomesodermin (EOMES) expression in lesional and non-lesional skin is suggestive of innate-like virtual memory CD8+ T cell infiltration. We found that signs of systemic inflammation were present in most of the patients, correlated with the severity of the disease, and pointed to IL-6 involvement in the pathogenesis of psoriatic arthritis. Among the circulating T cell subpopulations, we identified a higher proportion of terminally differentiated or senescent CD8+ T cells, especially in patients with long disease duration, suggesting premature immunosenescence and its possible implications for psoriasis co-morbidities.
Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors (2019)

KRASG12C has emerged as a promising target in the treatment of solid tumors. Covalent inhibitors targeting the mutant cysteine-12 residue have been shown to disrupt signaling by this long-“undruggable” target; however clinically viable inhibitors have yet to be identified. Here, we report efforts to exploit a cryptic pocket (H95/Y96/Q99) we identified in KRASG12C to identify inhibitors suitable for clinical development. Structure-based design efforts leading to the identification of a novel quinazolinone scaffold are described, along with optimization efforts that overcame a configurational stability issue arising from restricted rotation about an axially chiral biaryl bond. Biopharmaceutical optimization of the resulting leads culminated in the identification of AMG 510, a highly potent, selective, and well-tolerated KRASG12C inhibitor currently in phase I clinical trials (NCT03600883).
A visual tool to support technical analysis of stock market data (2006)

A stock market investor relies on two schools of analysis of market behavior to determine a trading strategy: Technical Analysis and Fundamental Analysis. Fundamental Analysis is based on the study of the fundamental data of a company and more directed to long-term investments, not taking into account small short-term price oscillations. On the other hand, Technical Analysis is mostly used for mid and short-term investments and is based on the study of past price behavior through the use of statistical tools and price history charts, taking into consideration the hypothesis that prices form patterns and reflect all the relevant information about a company and about the psychology of other investors. The application of Technical Analysis requires a computational system capable of displaying price history charts and providing tools to be used with them. This paper presents a prototype for a portable, extensible and easy-to-use tool for desktop/laptop and handheld computers that provides the investor with techniques for the visualization of stock market data. Classical visualization techniques and tools, such as Line, Bar, Candlestick and Point and Figure Charts, as well as extra tools, such as candlestick pattern recognition, are available as built-in functions, but new tools and visualizations can be easily added. The software was built with the .NET and .NET Compact frameworks and utilizes XML to store the data set.
Met Receptor Tyrosine Kinase Signaling Induces Secretion of the Angiogenic Chemokine Interleukin-8/CXCL8 in Pancreatic Cancer (2012)

At diagnosis, the majority of pancreatic cancer patients present with advanced disease when curative resection is no longer feasible and current therapeutic treatments are largely ineffective. An improved understanding of molecular targets for effective intervention of pancreatic cancer is thus urgent. The Met receptor tyrosine kinase is one candidate implicated in pancreatic cancer. Notably, Met is over expressed in up to 80% of invasive pancreatic cancers but not in normal ductal cells correlating with poor overall patient survival and increased recurrence rates following surgical resection. However the functional role of Met signaling in pancreatic cancer remains poorly understood. Here we used RNA interference to directly examine the pathobiological importance of increased Met signaling for pancreatic cancer. We show that Met knockdown in pancreatic tumor cells results in decreased cell survival, cell invasion, and migration on collagen I in vitro. Using an orthotopic model for pancreatic cancer, we provide in vivo evidence that Met knockdown reduced tumor burden correlating with decreased cell survival and tumor angiogenesis, with minimal effect on cell growth. Notably, we report that Met signaling regulates the secretion of the pro-angiogenic chemokine interleukin-8/CXCL8. Our data showing that the interleukin-8 receptors CXCR1 and CXCR2 are not expressed on pancreatic tumor cells, suggests a paracrine mechanism by which Met signaling regulates interleukin-8 secretion to remodel the tumor microenvironment, a novel finding that could have important clinical implications for improving the effectiveness of treatments for pancreatic cancer.
Automated processing of the single-lead electrocardiogram for the detection of obstructive sleep apnoea (2003)

A method for the automatic processing of the electrocardiogram (ECG) for the detection of obstructive apnoea is presented. The method screens nighttime single-lead ECG recordings for the presence of major sleep apnoea and provides a minute-by-minute analysis of disordered breathing. A large independently validated database of 70 ECG recordings acquired from normal subjects and subjects with obstructive and mixed sleep apnoea, each of approximately eight hours in duration, was used throughout the study. Thirty-five of these recordings were used for training and 35 retained for independent testing. A wide variety of features based on heartbeat intervals and an ECG-derived respiratory signal were considered. Classifiers based on linear and quadratic discriminants were compared. Feature selection and regularization of classifier parameters were used to optimize classifier performance. Results show that the normal recordings could be separated from the apnoea recordings with a 100% success rate and a minute-by-minute classification accuracy of over 90% is achievable.
Understanding of Intake Cam Phasing Effects on the Induction and Fuel-Air Mixing in a DISI Engine (2004)

&lt;div class="htmlview paragraph"&gt;Variable Cam Timing (VCT) has been proven to be a very effective method in PFI (Port Fuel Injection) engines for improved fuel economy and combustion stability, and reduced emissions. In DISI (Direct Injection Spark Ignition) engines, VCT is applied in both stratified-charge and homogeneous charge operating modes. In stratified-charge mode, VCT is used to reduce NOx emission and improve combustion stability. In homogeneous charge mode, the function of VCT is similar to that in PFI engines. In DISI engine, however, the VCT also affects the available fuel-air mixing time.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;This paper focuses on VCT effects on the induction process and the fuel-air mixing homogeneity in a DISI engine. The detailed induction process with large exhaust-intake valve overlap has been investigated with CFD modeling. Seven characteristic sub-processes during the induction have been identified. The associated mechanism for each sub-process is also investigated. Based on the physics of the induction process, the experimentally observed effect of cam phasing on engine manifold pressure is well understood. Both optical engine experiments and CFD modeling showed that retarding the intake cam improves the fuel-air mixing homogeneity over a wide VCT range. Dynamometer engine testing confirms the improved mixing as the CO emission decreases as the intake cam retards. Modeling revealed that the mixing improvement is not due to the overall large-scale in-cylinder flow structure, but due to the local small flow structures.&lt;/div&gt;
Settlement strategies in Manitoba : an examination of the intentions of the Government of Manitoba (1979)

Report : ii, 40 leaves : ill.
Commissioned by the Canada Ministry of State for Urban Affairs.
New tools derived from the solvatochromic 4-N,N-dimethylamino-1,8-naphthalimide fluorophore for the detection of biomolecular interactions (2009)

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2009.
Inhibition of the Arabidopsis bHLH transcription factor by monomerization through abscisic acid‐induced phosphorylation (2016)

We have demonstrated that the Arabidopsis basic helix-loop-helix (bHLH) transcription factor, ABA-responsive kinase substrate 1 (AKS1; also known as FLOWERING BHLH 3, FBH3), enhances K(+) channel expression in guard cells leading to stomatal opening. The expression is suppressed by ABA-induced phosphorylation of AKS1. Here we show that the phosphorylation results in the monomerization of AKS1 multimers and inhibits AKS1 binding to DNA. AKS1 forms homo-multimers which dissociate following phosphorylation. Replacement of a critical amino acid in the bHLH domain inhibited multimer formation and decreased the binding of AKS1 to DNA. The monomerization was elicited via phosphorylation at three serine residues, which is mediated by SNF1-related protein kinase 2.6 (SnRK2.6), in the vicinity of bHLH domain. Furthermore, ABA induced the phosphorylation-dependent release of AKS1 from DNA, thereby suppressing transcriptional activity in vivo. Our results document a mechanism that inhibits gene expression by phosphorylation of a bHLH transcription factor.
The Representation of Knowledge in Minds and Machines (1998)

Human knowledge can be represented as a propositional network in which the meaning of a node is defined by its position in the network. That is, the relationship between a node and its neighbours determines how this node is used in language understanding and production, i.e., its meaning. The propositions that make up such a network are predicate‐argument structures with time and location slots. Schemas, frames, and production rules can be expressed in the same formalism. Implications for this contextual view of meaning are discussed. Since the construction of such a propositional network depends on hand coding and is therefore impractical, an alternative automatic statistical procedure is explored that yields a high‐dimensional semantic space. Vectors in this space correspond to nodes in the propositional network, in that the meaning of a vector in the Latent Semantic Analysis space is given by its neighbouring vectors in that space.
Steady-State Modeling of Electroultrafiltration at Constant Concentration (1985)

Abstract A simple mathematical model was developed to predict the steady-state electroultrafiltration (a combination of ultrafiltration and electrophoresis) flux for processing bovine serum albumin (BSA) solutions at constant concentration. The assumption that the wall concentration is an exponential function of the electric field strength gave a linear dependence of flux on electric field strength. This dependence was experimentally confirmed for electroultrafiltration of 1–4 wt% BSA solutions at pH 7.4, using Amicon XM-50 membranes with a transmembrane pressure drop of 5 psig. The mathematical model uses the values of the solution and solvent fluxes for normal ultrafiltration plus the electrophoretic mobility of the solute to predict the electroultrafiltration flux. The difference between the model predictions and the measured performance was 7.5%.
[An autopsy report of malignant fibrous histiocytoma of the left atrium and a review of the pertinent literature]. (1990)

A 30-year-old male complaining of fever was admitted to hospital and a diagnosis of a malignant, fibrous histiocytoma (MFH) was established after a biopsy examination. Antitumor chemotherapy and Co60 irradiation was initiated. The patient, however, suddenly died of cardiac arrest 9 months after admission. The autopsy revealed a polypoid, yellow-white tumor (5 cm in diameter) arising from the antero-lateral wall of the left atrium and occupying the chamber. Twenty-two cases of MFH (21 previous reports and 1 current case) arising from the heart are reviewed.
Association of mutant EGFR L858R and exon 19 concentration in circulating cell-free DNA using droplet digital PCR with response to EGFR-TKIs in NSCLC (2017)

The present study aimed to determine the diagnostic concordance of plasma epidermal growth factor receptor (EGFR) mutation using droplet digital polymerase chain reaction (ddPCR) with tumor tissue samples and the predictive clinical significance of plasma EGFR mutation concentration. Plasma DNA samples from patients with non-small cell lung cancer (NSCLC) were analyzed for EGFR exon 21 codon 858 (L858R) mutation, deletion of exon 19 (ex19del) and exon 20 codon 790 (T790M) mutation using ddPCR. Firstly, the mutations in the plasma samples were compared with the matched tumor samples to determine the concordance. Secondly, image examination follow-ups were analyzed to assess the association between plasma EGFR mutation concentration and patients' response to EGFR-tyrosine kinase inhibitors (TKIs). A total of 51 patients with NSCLC were enrolled, including 48 newly diagnosed patients. Compared with tumor tissue samples, the sensitivity and specificity of ddPCR were 76.19% (16/21) and 96.55% (28/29) for mutant L858R, and 88.89% (8/9) and 100% (41/41) for ex19del, respectively. No patient exhibited the T790M mutation in the tumor tissue or plasma samples. Furthermore, 5 patients with the L858R mutation and 4 patients with ex19del in plasma and tumor tissue samples had been followed up with image examination for ≥3 months following EGFR-TKI treatment. The baseline mutant EGFR concentrations were positively correlated with a reduction in tumor burden (Spearman's r=0.7000, P=0.0358). When analyzed separately, ex19del concentrations (Spearman's r=1.0000, P<0.0001) were also positively correlated with the reduction, while mutant L858R concentrations were not (Spearman's r=0.7000, P=0.1881). In the present study, detection of plasma EGFR mutations using ddPCR exhibited sufficient concordance with tumor tissue sample results. Baseline plasma mutant EGFR and ex19del concentrations were significantly and positively correlated with response to EGFR-TKIs.
o-Methoxy Substituents in Spiro-OMeTAD for Efficient Inorganic–Organic Hybrid Perovskite Solar Cells (2014)

Three spiro-OMeTAD derivatives have been synthesized and characterized by (1)H/(13)C NMR spectroscopy and mass spectrometry. The optical and electronic properties of the derivatives were modified by changing the positions of the two methoxy substituents in each of the quadrants, as monitored by UV-vis spectroscopy and cyclic voltammetry measurements. The derivatives were employed as hole-transporting materials (HTMs), and their performances were compared for the fabrication of mesoporous TiO2/CH3NH3PbI3/HTM/Au solar cells. Surprisingly, the cell performance was dependent on the positions of the OMe substituents. The derivative with o-OMe substituents showed highly improved performance by exhibiting a short-circuit current density of 21.2 mA/cm(2), an open-circuit voltage of 1.02 V, and a fill factor of 77.6% under 1 sun illumination (100 mW/cm(2)), which resulted in an overall power conversion efficiency (PCE) of 16.7%, compared to ~15% for conventional p-OMe substituents. The PCE of 16.7% is the highest value reported to date for perovskite-based solar cells with spiro-OMeTAD.
Skin-Resident T Cells Sense Ultraviolet Radiation–Induced Injury and Contribute to DNA Repair (2014)

Skin-resident T cells have been shown to play important roles in tissue homeostasis and wound repair, but their role in UV radiation (UVR)-mediated skin injury and subsequent tissue regeneration is less clear. In this study, we demonstrate that acute UVR rapidly activates skin-resident T cells in humans and dendritic epidermal γδ T cells (DETCs) in mice through mechanisms involving the release of ATP from keratinocytes. Following UVR, extracellular ATP leads to an increase in CD69 expression, proliferation, and IL-17 production, and to changes in DETC morphology. Furthermore, we find that the purinergic receptor P2X7 and caspase-1 are necessary for UVR-induced IL-1 production in keratinocytes, which increases IL-17 secretion by DETCs. IL-17, in turn, induces epidermal TNF-related weak inducer of apoptosis and growth arrest and DNA damage-associated gene 45, two molecules linked to the DNA repair response. Finally, we demonstrate that DETCs and human skin-resident T cells limit DNA damage in keratinocytes. Taken together, our findings establish a novel role for skin-resident T cells in the UVR-associated DNA repair response and underscore the importance of skin-resident T cells to overall skin regeneration.
Active metasurface in the near-infrared region by gating ultrathin TiN films (2022)

Ultrathin titanium nitride (TiN) films have become a novel material flatform for constructing active metasurfaces in the near-infrared region. In this Letter, we numerically achieved the dual functions of switchable linear dichroism (LD) and tunable perfect absorption in a G-shape gold resonators/TiN film hybrid metasurface by gating ultrathin TiN films. As the carrier density of TiN decreases, the modulation depth for LD strength is about 70% at 1211 nm. Meanwhile, the response wavelength of perfect absorption (∼1) shifts to the blue by around 130 nm with a change of carrier density of 12%. Our proposed active metasurface with the capability of strength-switchable LD and wavelength-tunable perfect absorption has considerable potential in dynamic electro-optic modulation and flat photonic devices with reconfigurable functionalities.
A pipelined 5-Msample/s 9-bit analog-to-digital converter (1987)

A pipelined, 5-Msample/s, 9-b analog-to-digital converter with digital correction has been designed and fabricated in 3-/spl mu/m CMOS technology. It requires 8500 mil/SUP 2/, consumes 180 mW, and has an input capacitance of 3 pF. A fully differential architecture is used; only a two-phase nonoverlapping clock is required, and an on-chip sample-and-hold amplifier is included.
Nanophotonics Technology and Applications (2013)

This paper explores the role of nanotechnology with focus on nanophotonics in dielectric, metal, semiconductor inhomogeneous composition materials, as well as devices and subsystems for optical communications, information and signal processing, and sensing.