gebhart/patrepeval huggingface dataset:
Multiway Filtering Based on Fourth-Order Cumulants (2005)

We propose a new multiway filtering based on fourth-order cumulants for the denoising of noisy data tensor with correlated Gaussian noise. The classical multiway filtering is based on the TUCKALS3 algorithm that computes a lower-rank tensor approximation. The presented method relies on the statistics of the analyzed multicomponent signal. We first recall how the well-known lower rank- tensor approximation processed by TUCKALS3 alternating least square algorithm exploits second-order statistics. Then, we propose to introduce the fourth-order statistics in the TUCKALS3-based method. Indeed, the use of fourth-order cumulants enables to remove the Gaussian components of an additive noise. In the presented method the estimation of the -mode projector on the -mode signal subspace are built from the eigenvectors associated with the largest eigenvalues of a fourth-order cumulant slice matrix instead of a covariance matrix. Each projector is applied by means of the -mode product operator on the -mode of the data tensor. The qualitative results of the improved multiway TUCKALS3-based filterings are shown for the case of noise reduction in a color image and multicomponent seismic data.
Dual-acting peptide with prolonged glucagon-like peptide-1 receptor agonist and glucagon receptor antagonist activity for the treatment of type 2 diabetes (2007)

Type 2 diabetes is characterized by reduced insulin secretion from the pancreas and overproduction of glucose by the liver. Glucagon-like peptide-1 (GLP-1) promotes glucose-dependent insulin secretion from the pancreas, while glucagon promotes glucose output from the liver. Taking advantage of the homology between GLP-1 and glucagon, a GLP-1/glucagon hybrid peptide, dual-acting peptide for diabetes (DAPD), was identified with combined GLP-1 receptor agonist and glucagon receptor antagonist activity. To overcome its short plasma half-life DAPD was PEGylated, resulting in dramatically prolonged activity in vivo. PEGylated DAPD (PEG-DAPD) increases insulin and decreases glucose in a glucose tolerance test, evidence of GLP-1 receptor agonism. It also reduces blood glucose following a glucagon challenge and elevates fasting glucagon levels in mice, evidence of glucagon receptor antagonism. The PEG-DAPD effects on glucose tolerance are also observed in the presence of the GLP-1 antagonist peptide, exendin(9-39). An antidiabetic effect of PEG-DAPD is observed in db/db mice. Furthermore, PEGylation of DAPD eliminates the inhibition of gastrointestinal motility observed with GLP-1 and its analogues. Thus, PEG-DAPD has the potential to be developed as a novel dual-acting peptide to treat type 2 diabetes, with prolonged in vivo activity, and without the GI side-effects.
E/Z Conformation and the Vibrational Spectroscopy of Me2NN(O)NOMe (2005)

The simple neutral diazenium diolate, O2-methyl-1-(N, N-dimethylamino)diazen-1-ium-1,2-diolate, [Me2NN(O)=NOMe], was experimentally examined by vibrational spectroscopy and the results compared to the theoretically calculated values in an effort to detect both Z and E conformers which result from the stereochemistry of the N=N multiple bond. Room-temperature Raman and infrared spectra were measured and the results compared with the values calculated theoretically with MP2 and density functional techniques (B3LYP). An analysis of the observed frequencies suggests that, down to a detection limit of about 1/1000, only a small quantity of trans (E) diazeniumdiolate, <0.05%, may be present at room temperature.
TUTOR`S ROLES AND PERFORMANCES IN MODERN HUMAN ANATOMY COURSE SUPPORTED BY VIRTUAL TECHNOLOGY (2020)

Dynamical development of technologies changes not only education system in medicine at Rīga Stradiņš University, but there are a lot of performances in roles of the tutors, their skills and knowledge. The aim of this study was to investigate how the use of the 3D virtual dissection table “Anatomage”, like a platform for teaching of the students, transforms the tutor’s roles. In years 2016-2019 ten tutors learned the virtual technology well enough to utilize it in the practical classes and to integrate new, modern content into Human Anatomy curriculum at Department of Morphology. Tutors used virtual dissection platform and tools for a variety of purposes and in many ways. New technology helped tutors to develop topics with more interactive, complex tasks and collaboration among students, promoted required assessment methods and student self-assessment. Based on the variety of roles played by the Human Anatomy tutor in this virtual experience, through the focus groups we were fixed four main tutor’s roles types (technical, pedagogical, social and leadering). Variations in the usage of the “Anatomage” offered and reflected important performances, differences and divergences in tutors and their`s beliefs about the utility of this technology in the study course.
Selection Criteria for Plain and Segmented Finned Tubes for Heat Recovery Systems (1994)

Heat recovery heat exchangers with gas as one of the streams depend on the use of finned tubes to compensate for the inherently low gas heat transfer coefficient. Standard frequency welded “plain” fins were generally used in the past, until the high-frequency resistance welding technology permitted a cost-effective manufacture of “segmented” fins. The main advantage of this fin design (Fig. 1) is that it permits higher heat flux and hence smaller, lighter weight units for most operating conditions. While the criteria that dictate optimum design, such as compactness, weight, and cost per unit area favor the segmented fin design, a few other considerations such as fouling, ease of cleaning, and availability of dependable design methods have to be considered. This paper analyzes the performance parameters that affect the selection of either fin type.
Faculty Opinions recommendation of A Rad51 presynaptic filament is sufficient to capture nucleosomal homology during recombinational repair of a DNA double-strand break. (2008)

Read the full review for this Faculty Opinions recommended article: A Rad51 presynaptic filament is sufficient to capture nucleosomal homology during recombinational repair of a DNA double-strand break.
Determination of Tartaric Acid in Wine (1977)

Tartaric acid analyses (metapervanadyl tartrate color complex) of wines and tartaric acid standard solutions decolorized by carbon treatment were compared with those of samples decolorized by passage through a column containing an adsorptive resin. Recovery of tartaric acid (2000 mg/liter) added to a wine stripped of organic acids by anion-exchange treatment was more accurate when the wine decolorizing was by the resin treatment (99.6%) than by the carbon treatment (105.9%). Standard solutions of tartaric acid gave statistically the same color absorbance values when determined as untreated samples or resin-treated. Carbon treatment of standard solutions gave lower results, with absorbance decreasing with increasing concentration of carbon. Tartaric acid concentration of wines decolorized with different levels of carbon and calculated from comparison with tartaric acid standards treated with the equivalent carbon levels gave different results. Wines decolorized by the resin treatment resulted in lower concentrations of tartaric acid compared to the results of the same wine decolorized by the carbon treatment. Thus, results for tartaric acid in wines decolorized by the carbon treatment are questionable, whereas results in wines decolorized by the resin treatment are more accurate.
Robust Marchenko Focusing - Calibrating Surface Reflection with VSP Data (2017)

Summary Marchenko focusing utilizes only reflection measurements at the Earth’s surface and an estimate of the direct wave from a focusing point in the subsurface to the acquisition level in order to retrieve the Green’s function between the two. However, the method suffers when an erroneous scaling of the amplitudes and/or a constant phase-shift is introduced to the reflection response, and artifacts caused by internal multiples are not fully suppressed in the retrieved subsurface wave fields. We propose a workflow to calibrate the reflection response, prior to Green’s function retrieval via Marchenko focusing, using additional information in the form of a VSP dataset. First a virtual VSP dataset is estimated via Marchenko focusing, to subsequently compare its upgoing component to the upgoing part of the recorded VSP. Thereby, making it possible to correct for a constant phase shift applied to the reflection data. By identifying the minimum residual energy between the virtual VSP and the recorded VSP wave fields, an erroneous scaling of the reflection response can also be corrected. This workflow leads to a more robust Marchenko focusing, where the reflection response can be redatumed to a target zone in the subsurface and used for ghost-free imaging.
Pilot Study of the Feasibility of Assessing DNA Damage and Apoptosis Induced by Chemotherapy in Children with Acute Leukemias. (2005)

Abstract The aim of the present study was to explore whether early assessment of the extent of DNA damage in leukemic blasts and incidence of apoptosis induced during chemotherapy is feasible. The long term goal is to develop a rapid assay to assess the effectiveness of chemotherapy early in the course of treatment of leukemia. Mononuclear cells were isolated from blood samples of 7 ALL patients with peripheral blasts, 4 of whom were, at diagnosis, high-risk ALL while the remaining 3 were in relapse. The median age of the patients was 17 yrs (2–25 yrs) and all were entered into an anthracycline-containing drug regimen. Samples were collected: prior to drug administration; and, one hour after completion of the drug infusion. The extent of DNA damage was assessed by analysis of histone H2AX phosphorylation (γH2AX) occurring at sites of DNA double-strand breaks (DSBs), which could be detected immunocytochemically and measured by multiparameter flow cytometry in conjunction with DNA content. The incidence of apoptosis was estimated 1 h after drug administration and also after 24 h ex vivo culturing, by identification of cells with DNA fragmentation detected by the TUNEL assay. In patients with complete clinical response (6 of 7) at the end of the induction phase, an increase of γH2AX (post treatment - pretreatment mean) was detected 1 h after the administration of drug treatment. The apoptotic index in this group after 24 h ex vivo culture was 1–16%. In the only patient not responding to treatment - one of 2 relapsed ALL patients -, there was no induction of DSBs or increase in apoptosis. Response to induction therapy γH2AX mean fluorescence in arbitrary units Apoptotic index ex vivo (%) post 24 h Complete response 8 16 Complete response 8 5 Complete response 5 1 Complete response 29 7 No response 0 0 Complete response 4 2 Complete response 4 Not estimated Although the number of patients is very small in this pilot study, the results suggest that a cytometric assay that reveals the extent of DNA damage based on detection of H2AX phosphorylation may provide an early prognostic marker.
State model for scheduling Built-in Self-Test and scrubbing in FPGA to maximize the system availability in space applications (2011)

Reconfigurable Field Programmable Gate Arrays (rFPGAs) are employed extensively in spacecraft electronic systems to implement low-power adaptable systems that provide high density functionality. A challenge that must be tackled during system design is their high susceptibility to radiation induced Single Event Upsets (SEUs). A burst of energized particles may cause extensive damage to circuits. Even if their presence is transient, SEU faults may cause a permanent failure when they afflict the configuration memory - SRAM. There are two ways in which timely detection of faults and timely action to circumvent them can be undertaken - (i) Online error detecting/correcting circuits that demand a high premium in terms of FPGA area for extending error-security and Fault Tolerance, thus increasing cost and redundancy, and (ii) Built-in Self-Test (BIST) that allows efficient and very high-coverage fault detection but the fault testing is performed off-line. In general, Reliability and Availability (R&A) is a crucial quality parameter. In this paper, we present a state model that schedules Self-tests judiciously to optimize availability while ensuring a high degree of reliability. The aim of system design is to determine an optimal value of the mean time to self testing λ <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> so that faults are detected on time and are reconfigured to boost system availability.
Cochaperone Mzb1 is a key effector of Blimp1 in plasma cell differentiation and β1-integrin function (2018)

Plasma cell differentiation involves coordinated changes in gene expression and functional properties of B cells. Here, we study the role of Mzb1, a Grp94 cochaperone that is expressed in marginal zone (MZ) B cells and during the terminal differentiation of B cells to antibody-secreting cells. By analyzing <i>Mzb1</i><sup><i>-/-</i></sup><i>Prdm1</i><sup><i>+/gfp</i></sup> mice, we find that Mzb1 is specifically required for the differentiation and function of antibody-secreting cells in a T cell-independent immune response. We find that Mzb1-deficiency mimics, in part, the phenotype of Blimp1 deficiency, including the impaired secretion of IgM and the deregulation of Blimp1 target genes. In addition, we find that <i>Mzb1</i><sup><i>-/-</i></sup> plasmablasts show a reduced activation of β1-integrin, which contributes to the impaired plasmablast differentiation and migration of antibody-secreting cells to the bone marrow. Thus, Mzb1 function is required for multiple aspects of plasma cell differentiation.
Laboratory work as scientific method: three decades of confusion and distortion (1996)

Abstract The justification advanced by teachers and curriculum developers for investing so much time, energy and resources in laboratory work in school science courses almost invariably includes the claim that it provides students with insight into, and experience and practice of, the methods of science. This paper traces the changing nature of laboratory work from the 1960s to the present, from discovery learning to process‐led science to contemporary constructivist approaches, and argues that each of these styles of laboratory work has seriously misrepresented and distorted the nature of scientific inquiry. Some suggestions are made for the re‐orientation of laboratory work to ensure that it projects an image of science that more faithfully reflects actual scientific practice. Additional informationNotes on contributorsDerek Hodson Derek Hodson is Professor of Science Education at the Ontario Institute for Studies in Education, 252 Bloor St West, Toronto, Ontario M5s 1v6, Canada. His interests are science and technology education and the education of teachers.
Hospice Programs and the Hospice Movement: An Investigation Based on General Systems Theory (1989)

This study used General Systems Theory as the framework for examining hospice programs and the hospice movement. Data drawn from program administrators and archival sources were used to test the thesis that two broad types of hospice programs exist in the United States. Results indicate that independent programs tend to be characterized by processes that amplify change in the extant medical delivery system--that is, deviation amplification. Hospices associated with preexisting institutions tend to be characterized by processes that counteract change, thus maintaining the status quo--that is, deviation counteracting processes.
Atomic force microscopy images of T4 bacteriophages on silicon substrates (1991)

A new atomic force microscope incorporating microfabricated cantilevers and employing laser beam deflection for force detection has been constructed and is being applied to studied of biological material. In this study, T4 bacteriophage virus particles were deposited from solution onto electronic grade flat silicon wafers and imaged in air with the microscope. Microliter droplets of the solution were deposited and either allowed to dry or removed with blotting paper. The images show both isolated viruses and aggregates of various sizes. The external structure as well as strands believed to be DNA streaming out of the virus could be observed. The construction of the microscope and its performance are also described. 19 refs., 4 figs.
Dietary DHA supplementation causes selective changes in phospholipids from different brain regions in both wild type mice and the Tg2576 mouse model of Alzheimer's disease (2016)

Alzheimer's disease (AD) is of major concern in ageing populations and we have used the Tg2576 mouse model to understand connections between brain lipids and amyloid pathology. Because dietary docosahexaenoic acid (DHA) has been identified as beneficial, we compared mice fed with a DHA-supplemented diet to those on a nutritionally-sufficient diet. Major phospholipids from cortex, hippocampus and cerebellum were separated and analysed. Each phosphoglyceride had a characteristic fatty acid composition which was similar in cortex and hippocampus but different in the cerebellum. The biggest changes on DHA-supplementation were within ethanolamine phospholipids which, together with phosphatidylserine, had the highest proportions of DHA. Reciprocal alterations in DHA and arachidonate were found. The main diet-induced alterations were found in ethanolamine phospholipids, (and included their ether derivatives), as were the changes observed due to genotype. Tg mice appeared more sensitive to diet with generally lower DHA percentages when on the standard diet and higher relative proportions of DHA when the diet was supplemented. All four major phosphoglycerides analysed showed age-dependent decreases in polyunsaturated fatty acid contents. These data provide, for the first time, a detailed evaluation of phospholipids in different brain areas previously shown to be relevant to behaviour in the Tg2576 mouse model for AD. The lipid changes observed with genotype are consistent with the subtle alterations found in AD patients, especially for the ethanolamine phospholipid molecular species. They also emphasise the contrasting changes in fatty acid content induced by DHA supplementation within individual phospholipid classes.
Enzymatically active prostate‐specific antigen promotes growth of human prostate cancers (2011)

These studies demonstrate the importance of PSA to prostate cancer cell growth. We also show that the enzymatic activity of PSA confers an enhanced growth rate to human prostate cancer cells, suggesting a causal role in prostate cancer progression.
CABLE TIE COMPRESSION TO FACILITATE LAPAROSCOPIC PARTIAL NEPHRECTOMY (2001)

No AccessJournal of UrologyCLINICAL UROLOGY: Case Reports1 Jan 2001CABLE TIE COMPRESSION TO FACILITATE LAPAROSCOPIC PARTIAL NEPHRECTOMY JEFFREY A. CADEDDU and T.SPARK CORWIN JEFFREY A. CADEDDUJEFFREY A. CADEDDU and T.SPARK CORWINT.SPARK CORWIN View All Author Informationhttps://doi.org/10.1097/00005392-200101000-00043AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "CABLE TIE COMPRESSION TO FACILITATE LAPAROSCOPIC PARTIAL NEPHRECTOMY." The Journal of Urology, 165(1), pp. 177–178 References 1 : Hemostasis techniques in partial nephrectomy. Prog Urol1996; 6: 605. Google Scholar 2 : Pledgeted sutures for parenchymal compression facilitate partial nephrectomy. Br J Urol1998; 81: 630. Google Scholar 3 : Hemostatic control with flexible compression tape used during partial nephrectomy and organ salvage. J Urol1999; 162: 458. Abstract, Google Scholar From the Department of Urology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas© 2001 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byFINLEY D, LEE D, EICHEL L, URIBE C, McDOUGALL E and CLAYMAN R (2018) FIBRIN GLUE-OXIDIZED CELLULOSE SANDWICH FOR LAPAROSCOPIC WEDGE RESECTION OF SMALL RENAL LESIONSJournal of Urology, VOL. 173, NO. 5, (1477-1481), Online publication date: 1-May-2005.PARK E, ULREICH J, SCOTT K, ULLRICH N, LINEHAN J, FRENCH M, HO W, WHITE M, TALLEY J, FELLAH A and RAMAKUMAR S (2018) EVALUATION OF POLYETHYLENE GLYCOL BASED HYDROGEL FOR TISSUE SEALING AFTER LAPAROSCOPIC PARTIAL NEPHRECTOMY IN A PORCINE MODELJournal of Urology, VOL. 172, NO. 6 Part 1, (2446-2550), Online publication date: 1-Dec-2004.ORVIETO M, CHIEN G, LAVEN B, RAPP D, SOKOLOFF M and SHALHAV A (2018) ELIMINATING KNOT TYING DURING WARM ISCHEMIA TIME FOR LAPAROSCOPIC PARTIAL NEPHRECTOMYJournal of Urology, VOL. 172, NO. 6 Part 1, (2292-2295), Online publication date: 1-Dec-2004. Volume 165Issue 1January 2001Page: 177-178 Advertisement Copyright & Permissions© 2001 by American Urological Association, Inc.KeywordshemostasisnephrectomylaparoscopykidneyMetricsAuthor Information JEFFREY A. CADEDDU More articles by this author T.SPARK CORWIN More articles by this author Expand All Advertisement PDF downloadLoading ...
The Effect of the transducer parameters on spatial resolution in Plane-Wave imaging (2015)

Plane-Wave imaging (PWI) can produce a complete image after a single transmission of an unfocused ultrasound beam, and therefore can achieve ultrahigh frame rates of thousands frames per second. Many ultrasound imaging applications, such as shear wave elastography, require ultrahigh frame rates. However, due to the lack of a focusing point in PWI, it is not possible to derive an expression for the spatial resolution based on the f-number. This work aims to study the transducer parameters that affect the imaging quality in PWI in form of spatial resolution. Ultrasound imaging systems with different frequencies, bandwidths and transducer widths at a range of imaging depths are simulated and the effect of each parameter is studied separately. Based on this study, an empirical expression for PWI lateral resolution is produced, which reveals the direct proportion of the lateral resolution with the wavelength and imaging depth and the inverse proportion with the total width of the transducer.
Embryo transfer by midwife or gynecologist: a prospective randomized study (2003)

The results show that it is a feasible option to allow midwives to carry out ETs.
Magnet array for a portable magnetic resonance imaging system (2015)

Conventional magnetic resonance imaging (MRI) scanners are bulky and heavy. It limits their applications at places, for example, in an ambulance or in a combat field hospital. The disadvantages of a conventional MRI system have led to increasing interests in the development of a portable MRI one. One of the challenges for a portable MRI scanner is to build a homogenous static magnetic field within a volume of the size of human parts, for example, human head, for imaging. In this paper, we presented the design and development of a modified permanent magnet array for a portable MRI scanner. The measurement method of the magnetic field is included.
A Novel Gesture–based CAPTCHA Design for Smart Devices (2013)

CAPTCHAs have been widely used in Web applications to prevent service abuse. With the evolution of computing environment from desktop computing to ubiquitous computing, more and more users are accessing Web applications on smart devices where touch based interactions are dominant. However, the majority of CAPTCHAs are designed for use on computers and laptops which do not reflect the shift of interaction style very well. In this paper, we propose a novel CAPTCHA design to utilise the convenience of touch interface while retaining the needed security. This is achieved through using a hybrid challenge to take advantages of human’s cognitive abilities. A prototype is also developed and found to be more user friendly than conventional CAPTCHAs in the preliminary user acceptance test.