gebhart/patrepeval huggingface dataset:
Concordance of Gross Surgical and Final Fixed Margins in Vulvar Intraepithelial Neoplasia 3 and Vulvar Cancer (2006)

Although vulvar cancer still accounts for approximately 5% of gynecologic malignancies, the incidence of vulvar intraepithelial neoplasia (VIN) has nearly doubled in the past 2 decades. When VIN 3 is severe and not treated, this lesion may progress to frank cancer. Excision is most often preferred to obtain negative surgical margins and to rule out occult invasive cancer—present in up to 20% of patients with biopsy-proved VIN 3. Traditionally, a margin of 2 to 3 cm has been recommended after vulvectomy. This prospective study compared gross surgical margins with final fixed gross margins in 27 women over age 18 who had biopsy-proved VIN 3 or vulvar carcinoma. More than 80% of the women smoked, and nearly 60% had a history of genital dysplasia. Five participants had invasive cancer on preoperative biopsy, whereas 22 had VIN 3. Invasive carcinoma was at stage I in 2 cases, stage II in one, and stage III in 2. Two other cancers were found among women with a preoperative diagnosis of VIN 3, but both were stage IA lesions. After highlighting the vulvar lesion using acetic acid, sutures were placed so as to mark a 1-cm margin for both dysplasia and carcinoma. In the 19 women who could be evaluated, the median fixed margin was 0.85 cm and the mean was 0.83 cm. The difference between the gross and final fixed margins was significant at a level of P = .001. Seven of the 19 women had microscopic VIN 1 and 3 were VIN 3 within the grossly negative 1-cm specimen. In no case, however, did VIN extend beyond the excised 1-cm margin. These findings suggest that when measured in its final fixed state, the gross surgical margin after resection of invasive vulvar cancer or VIN 3 is reduced by approximately 15%. When attempting to gain a negative margin exceeding 8 mm, surgeons may place confidence in a gross surgical margin of 1 cm for VIN 3 and 1 to 2 cm for invasive cancer.
A Review of Antennas for Picosatellite Applications (2017)

Cube Satellite (CubeSat) technology is an attractive emerging alternative to conventional satellites in radio astronomy, earth observation, weather forecasting, space research, and communications. Its size, however, poses a more challenging restriction on the circuitry and components as they are expected to be closely spaced and very power efficient. One of the main components that will require careful design for CubeSats is their antennas, as they are needed to be lightweight, small in size, and compact or deployable for larger antennas. This paper presents a review of antennas suitable for picosatellite applications. An overview of the applications of picosatellites will first be explained, prior to a discussion on their antenna requirements. Material and antenna topologies which have been used will be subsequently discussed prior to the presentation of several deployable configurations. Finally, a perspective and future research work on CubeSat antennas will be discussed in the conclusion.
Supplementary Figure Legends 1-5, Table Legends 1-2 from A Central Role for RAF→MEK→ERK Signaling in the Genesis of Pancreatic Ductal Adenocarcinoma (2023)

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Altered T‐cell subpopulations in recurrent pregnancy loss patients with cellular immune abnormalities (2018)

Recurrent pregnancy loss (RPL) is a multifactorial disorder of women in reproductive age, which in some cases is caused by immunologic abnormalities. In this study, we aimed to evaluate cellular and molecular components of the immune system like different T-cell subsets and their regulating microRNAs (miRNAs) in RPL women and control group. Fifty RPL and 50 healthy subjects were recruited. Subsets of T cells, including regulatory T (Treg) cells, helper T (Th) 17 cells, exhausted T cells, exhausted Treg cells were evaluated by flow cytometry. Transcription factors of T cells and related miRNA profile were quantified using real-time polymerase chain reaction (RT-PCR). Assessment showed that Treg and exhausted T cells, were decreased in RPL patients (p = 0.009 and 0.02, respectively), while an increase was observed in Th17 and exhausted Treg frequency ( p = 0.013 and 0.0037, respectively). Messenger RNA expression level of T-bet and IRF4 was upregulated in RPL patients ( p = 0.011 and 0.0001, respectively), while Th2- and Treg-related transcription factors, GATA3 and GITR, were downregulated in these patients compared with the healthy subjects ( p = 0.0008 and <0.000, respectively). Treg-associated miRNAs, the miR-106b-25-93 cluster, showed a higher rate in RPL patients ( P = 0.007, 0.001, and 0.029, respectively), however, we observed no significant difference in the expression level of Th17-associated miRNA, mir-326. According to the results, we concluded that unbalanced immune responses and deregulated function of T-cell subsets may lead to reproduction-related failure like a miscarriage. Therefore, evaluation of immune cells and related miRNA profile may serve as prognostic biomarker for the treatment of RPL patients.
Performance of Nitrogen Removal by Pseudomonas sp. WSH 1001 (2012)

The influence factors of ammonia-and nitrate-nitrogen removal capability by Pseudomonas sp.WSH 1001,its application in actual wastewater and the comparison in nitrogen removal capability between Pseudomonas sp.WSH 1001 and other commercially available microbial preparations were studied in this research.The results indicated that ammonia-and nitrate-nitrogen removal capability was higher when glucose or sodium citrate was used as carbon sources in the pre-cultured process of Pseudomonas sp.WSH 1001.The temperature between 20 ℃ and 35 ℃ had no effect on ammonia-and nitratenitrogen removal efficiency.The dissolved oxygen level in shaking flask greatly influenced ammonia-and nitrate-nitrogen removal efficiency.Metal ions such as Cu2+,Co2+and Zn2+greatly inhibited the capability of the strain to remove ammonia-and nitrate-nitrogen.When initial ammonia nitrogen concentration was 70 mg L-1 in synthetic waste water,ammonia nitrogen and total nitrogen removal efficiency were 99.64% and 94.94% in 6 h,respectively.When nitrate nitrogen was used as sole nitrogen source(50 mg L-1),nitrogen removal efficiency was 87.69% in 8 h.When Pseudomonas sp.WSH 1001 was used as microbial preparation in the treatment of actual wastewater(the initial concentration of ammonia nitrogen and COD was 44 and 113 mg L-1,respectively) supplemented with 3 g L-1 sodium succinate as external carbon source,ammonia nitrogen removal efficiency was 99.23%,which was higher than those of other commercially available microbial preparations.It is demonstrated that Pseudomonas sp.WSH 1001 was favorable to practical application.
An Empirical Methodology to Evaluate Vulnerability Discovery Models (2014)

Vulnerability discovery models (VDMs) operate on known vulnerability data to estimate the total number of vulnerabilities that will be reported after a software is released. VDMs have been proposed by industry and academia, but there has been no systematic independent evaluation by researchers who are not model proponents. Moreover, the traditional evaluation methodology has some issues that biased previous studies in the field. In this work we propose an empirical methodology that systematically evaluates the performance of VDMs along two dimensions (quality and predictability) and addresses all identified issues of the traditional methodology. We conduct an experiment to evaluate most existing VDMs on popular web browsers' vulnerability data. Our comparison shows that the results obtained by the proposed methodology are more informative than those by the traditional methodology. Among evaluated VDMs, the simplest linear model is the most appropriate choice in terms of both quality and predictability for the first 6-12 months since a release date. Otherwise, logistics-based models are better choices.
Inverse reflectometry for real objects with diffuse and specular interreflections (2006)

Abstract In the study of composite reality, in which virtual objects are synthesized and displayed in a real environment, intensive research is under way on virtual reality in order to achieve the virtual representation of real objects with a greater resemblance to reality. The estimation of the surface reflection characteristics of the object is especially important in order to eliminate inconsistencies of shadow between the real environment and the virtual object. To deal with this problem, we are continuing the study of dense estimation of the reflection characteristics of objects from distant images and surface texture images. For objects of complex shape, we have proposed a method of taking account of the effect of mutual reflection due to the secondary reflections on the object surface. However, there remains the problem that the effect of mutual reflection by specular‐reflection components cannot be eliminated. Consequently, a method is proposed in this paper which estimates the reflectance with allowance for the effect of mutual reflection, including the specular reflection component on the object surface. Specifically, the method is as follows. First, the illumination conditions with regard to the direction of illumination are determined from the object shape in order to observe the reflection component at a large number of points on the object surface. Based on the determined multiple illumination conditions and the measured data, photon mapping is applied, using the photon distribution on the object surface to estimate the surface reflectance at each point on the surface. In experiments, the estimated reflectance is compared to the results obtained by conventional methods, and it is shown that the proposed method can represent objects faithfully under various illumination conditions in the virtual environment. © 2006 Wiley Periodicals, Inc. Electron Comm Jpn Pt 2, 90(1): 50–60, 2007; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/ecjb.20324
Electrophoretic deposition of BaTi0.85Zr0.15O3 nanopowders (2013)

The present study reports the results of thick films (20-130 µm) produced through electrophoretic deposition of BaTi0.85Zr0.15O3 (BTZ) nanometric powders synthesized by the Pechini's method. The BTZ powderscalcined at 600°C/2h presented a single crystalline phase with an average particle size of ~20nm. To thick films deposition, a stable suspension of acetylacetone (Acac) and ethanol (EtOH)was prepared and the powder was deposited on platinum substrates. The viscosity of BTZ powders suspensions as a function of operational pH (OpH)was measured and the reactions between nanoparticles and the media were discussed. A milling process was used to deagglomerate the powders and it had a great influence in the suspension stability and deposition of thick films. Dense and crack-free thick films were obtained after sintering at 1220 °C/1h. The dielectric properties results, comparable with those of bulk BTZ ceramics, suggested potential applications of the EPD process for the deposition of ferroelectric/piezoelectric thick films.
The Black Falcon: a teleoperated surgical instrument for minimally invasive surgery (2002)

This paper presents the Black Falcon, an eight degree-of-freedom teleoperator slave with a dextrous wrist for minimally invasive surgery (MIS). We show how teleoperation can address several key problems in MIS by increasing dexterity and degrees of freedom, by giving the surgeon some force feedback to feel instrument-tissue interactions and by eliminating geometric discrepancies between actual and observed tool motions. We discuss relevant design constraints, summarize the mechanism design and give data showing the quality of force reflection achieved. We demonstrate suturing along arbitrarily oriented suture lines in animal tissue, a task essentially impossible using current instruments.
Pursuit of reinitiation efficiency of resonance‐stabilized monomeric allyl radical generated via “degradative monomer chain transfer” in allyl polymerization (2010)

Abstract For a deeper understanding of allyl polymerization mechanism, the reinitiation efficiency of resonance‐stabilized monomeric allyl radical was pursued because in allyl polymerization it is commonly conceived that the monomeric allyl radical generated via the allylic hydrogen abstraction of growing polymer radical from monomer, i.e., “degradative monomer chain transfer,” has much less tendency to initiate a new polymer chain and, therefore, this monomer chain transfer is essentially a termination reaction. Based on the renewed allyl polymerization mechanism in our preceding article, the monomer chain transfer constant in the polymerization of allyl benzoate was estimated to be 2.7 × 10 −2 at 80 °C under the polymerization condition, where the coupling termination reaction of growing polymer radical with allyl radical was negligible and, concurrently, the reinitiation reaction of allyl radical was enhanced significantly. The reinitiation efficiencies of monomeric allyl radical were pursued by the dead‐end polymerizations of allyl benzoate at 80, 105, and 130 °C using a small amount of initiators; they increased remarkably with raised temperature. Thus, the enhanced reinitiation reactivity of allyl radical at an elevated temperature could bias the well‐known degradative monomer chain transfer characteristic of allyl polymerization toward the chain transfer in common vinyl polymerization. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2010
A Unified Approach to Energy-Efficient Power Control in Large CDMA Systems (2007)

A unified approach to energy-efficient power control is proposed for code-division multiple access (CDMA) networks. The approach is applicable to a large family of multiuser receivers including the matched filter, the decorrelator, the linear minimum mean-square error (MMSE) receiver, and the (nonlinear) optimal detectors. It exploits the linear relationship that has been shown to exist between the transmit power and the output signal-to-interference-plus-noise ratio (SIR) in the large-system limit. It is shown that, for this family of receivers, when users seek to selfishly maximize their own energy efficiency, the Nash equilibrium is SIR-balanced. In addition, a unified power control (UPC) algorithm for reaching the Nash equilibrium is proposed. The algorithm adjusts the user's transmit powers by iteratively computing the large-system multiuser efficiency, which is independent of instantaneous spreading sequences. The convergence of the algorithm is proved for the matched filter, the decorrelator, and the MMSE receiver, and is demonstrated by means of simulation for an optimal detector. Moreover, the performance of the algorithm in finite-size systems is studied and compared with that of a conventional power control scheme, in which user powers depend on the instantaneous spreading sequences.
Genetic heterogeneity of autosomal recessive limbgirdle muscular dystrophy in a genetic isolate (Amish) and evidence for a new locus (1995)

Limb-girdle muscular dystrophy (LGMD) is a hereditary myopathy presenting clinical and genetic heterogeneity. In 1991, a recessive form (LGMD2A) was linked to chromosome 15q in a genetic isolate from the Isle of La Réunion. Confirmation of this localization was subsequently reported in Brazilian and northern Indiana Amish pedigrees. Here we report the exclusion of the LGMD2A locus in six Amish kindreds from southern Indiana that are related by multiple consanguineous links to the same northern Indiana families in which the involvement of the chromosome 15 locus was previously demonstrated. These findings indicate unexpected genetic heterogeneity of LGMD in an Indiana Amish isolate. Furthermore, genetic analyses also ruled out the possible involvement of the chromosome 2 locus recently described (LGMD2B), thus demonstrating that a mutation within at least one additional locus leads to this condition. Several candidate genes putatively involved in neuromuscular disorders were also excluded.
Effect of oestrogen status on serum levels of growth hormone‐binding protein and insulin‐like growth factor‐I in non‐pregnant and pregnant women (1993)

In non-pregnant women the endogenous oestrogen status seems to modulate negatively GHBP levels and positively IGF-I levels, whereas oral oestrogen administration, in contrast, increases serum levels of GHBP without modification of IGF-I levels. During pregnancy serum GHBP levels increase slightly during the first half of pregnancy and decrease thereafter, whereas IGF-I concentrations increase during the second part of pregnancy. The oestrogen status of women has a complex effect on serum concentrations of GHBP and IGF-I and has therefore to be taken into account when evaluating serum levels of GHBP and IGF-I.
Use of a device-based remote management heart failure care pathway is associated with reduced hospitalization and improved patient outcomes: TriageHF Plus real-world evaluation (2022)

Abstract Background Heart failure (HF) is a leading cause of hospital admission. However, prompt identification of worsening HF using implantable device data and proactive intervention may reduce hospitalizations. The validated TriageHF algorithm in enabled ICD/CRT devices uses sensor data to risk stratify patients for HF hospitalization in the next 30 days. TriageHF Plus is a novel device-based HF care pathway (DHFP) that uses “high” risk status as the trigger for remote intervention (see Figure 1 for pathway overview). Outcomes after DHFP implementation in a clinical setting have not been examined. Purpose To evaluate the impact of TriageHF Plus clinical pathway on hospitalisation rates. Methods A prospective, multi-center evaluation comparing monthly hospitalization rates for patients enrolled in a DHFP with a concurrent standard of care (SoC) cohort and characterizing staffing resources necessary to implement the DHFP. The DHFP cohort received telephonic assessment and guideline-directed clinical care upon transition to high-risk status. Propensity scores (PS) were applied to DHFP and SoC cohorts to allow unbiased comparison. A negative binomial model was fitted to the monthly number of all-cause hospitalizations with treatment group (DHFP vs. SoC) as a covariate, using PS as weights. Results Between 09/11/2019 and 06/24/2021, 758 patients were included in the study (443 DHFP, 315 SoC). Proportion CRT 76%/ 89% and LVEF &amp;lt;50% 78%/ 66% for DHFP/ SoC, respectively. 196 high risk transmissions prompted telephone assessment, with successful contact in 182; of which, 79 (43%) identified an explanatory acute medical issue. A secondary intervention was undertaken in 44/79 (56%). High risk transmissions took on average 19 minutes per clinical assessment (initial telephone triage and 30 day follow up). The rate of hospitalizations was 58% lower in the DHFP group, compared with SoC, after PS adjustment (IRR 0.42, 95% CI: 0.23, 0.76, p=0.004), see Figure 2. Sensitivity analyses showed Covid-19 had little effect on results. Conclusions This is the first prospective, real-world evaluation of a device-based HF care pathway to report a reduction in hospitalizations and does so with minimal staffing time. Integrated into existing HF services, device-based remote monitoring of HF patients can improve outcomes. Funding Acknowledgement Type of funding sources: Private company. Main funding source(s): Medtronic
Adiponectin Enhances IL-6 Production in Human Synovial Fibroblast via an AdipoR1 Receptor, AMPK, p38, and NF-κB Pathway (2007)

Articular adipose tissue is a ubiquitous component of human joints, and adiponectin is a protein hormone secreted predominantly by differentiated adipocytes and involved in energy homeostasis. We investigated the signaling pathway involved in IL-6 production caused by adiponectin in both rheumatoid arthritis synovial fibroblasts and osteoarthritis synovial fibroblasts. Rheumatoid arthritis synovial fibroblasts and osteoarthritis synovial fibroblasts expressed the AdipoR1 and AdipoR2 isoforms of the adiponectin receptor. Adiponectin caused concentration- and time-dependent increases in IL-6 production. Adiponectin-mediated IL-6 production was attenuated by AdipoR1 and 5'-AMP-activated protein kinase (AMPK)alpha1 small interference RNA. Pretreatment with AMPK inhibitor (araA and compound C), p38 inhibitor (SB203580), NF-kappaB inhibitor, IkappaB protease inhibitor, and NF-kappaB inhibitor peptide also inhibited the potentiating action of adiponectin. Adiponectin increased the kinase activity and phosphorylation of AMPK and p38. Stimulation of synovial fibroblasts with adiponectin activated IkappaB kinase alpha/beta (IKK alpha/beta), IkappaBalpha phosphorylation, IkappaBalpha degradation, p65 phosphorylation at Ser (276), p65 and p50 translocation from the cytosol to the nucleus, and kappaB-luciferase activity. Adiponectin-mediated an increase of IKK alpha/beta activity, kappaB-luciferase activity, and p65 and p50 binding to the NF-kappaB element and was inhibited by compound C, SB203580 and AdipoR1 small interference RNA. Our results suggest that adiponectin increased IL-6 production in synovial fibroblasts via the AdipoR1 receptor/AMPK/p38/IKKalphabeta and NF-kappaB signaling pathway.
High-external-quantum-efficiency organic light-emitting devices (1997)

We study the internal and external quantum efficiencies of vacuum-deposited organic light-emitting devices (OLED's). The internal quantum efficiency of OLED's based on tris-(8-hydroxyquinoline) aluminum is calculated to be 5.7 times the observed external quantum efficiency ?(e), consistent with measurements. We demonstrate a shaped substrate that increases ?(e) by a factor of 1.9+/-0.2 over similar OLED's fabricated upon flat glass substrates and leads to a 100%-emissive aperture, i.e., the emitting area completely occupies the display area even in the presence of metal interconnects. We also discuss a substrate structure that increases ?(e) by an additional factor of 2. The high device efficiencies are promising for developing OLED-based displays with extremely low power consumption and increased operational lifetime.
Increased levels of circulating endothelial progenitor cells in subjects with moderate to severe chronic periodontitis (2009)

This study shows for the first time that moderate to severe CP is associated with an increased level of circulating EPC.
Dissolution Rate And Formulation Studies On Solid Dispersions Of Itraconazole (2000)

Solid dispersions of itraconazole (ITR) in polyvinylpyrrolidone (PVP), hydroxy propyl methyl cellulose (HPMC), hydroxy propyl cellulose (HPC) and their tablet formulations were investigated with an objective of enhancing the dissolution rate of ITR from tablets. A marked enhancement in the dissolution rate of ITR was observed with all the solid dispersions. HPC gave the highest improvement (7.5 fold) in the dissolution rate of ITR at 10% concentration when compared to ITR itself. XRD indicated the presence of ITR in amorphous form in ITR-HPC solid dispersion and the crystallinity of ITR was much reduced in ITRHPMC and ITR-PVP solid dispersions. DSC indicated no interaction between ITR and PVP, HPMC and HPC. The solid dispersions could be formulated into tablets. These tablets, apart from fulfilling all official and other specifications, exhibited higher rates of dissolution and dissolution efficiency (DE) values.