gebhart/patrepeval huggingface dataset:
Effect of the Lingzi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) on Hyperglycemia and Dyslipidemia with Experimental Metabolic Syndrome (2023)

The effect of Ganoderma lucidum hot water extract of submerged cultivated mycelium suspensia on carbohydrate metabolism and lipid profile during fructose-induced metabolic syndrome in rats was studied. The outbred white male Wistar rats, in which metabolic syndrome was induced by consuming a 10% fructose solution instead of drinking water for 42 days, were used. After the induction of metabolic syndrome, the mycelium of G. lucidum in the form of water suspension (a dose of 1 g/kg of the animal's body weight) was administered to animals per os for 7 and 14 days. Glucose concentration was determined using the glucose oxidase method. The content of glycosylated hemoglobin in erythrocytes was determined by the colorimetric method. The concentration of triglycerides, cholesterol, high-density lipoproteins, and low-density lipoproteins in blood plasma was determined by enzymatic methods. A significant decrease in the content of glycosylated hemoglobin was established in animals with metabolic syndrome against the background of administration of the studied suspension. Under the conditions of experimental metabolic syndrome, the administration of mycelium for 7 and 14 days led to a decrease in the concentration of triglycerides by 17.8 and 44.8%, cholesterol by 10.7 and 21.3%, low-density lipoproteins by 14.8 and 28.4%, and to an increase in high-density lipoproteins concentration by 11.9 and 21.5%, compared with metabolic syndrome. The obtained results demonstrate the corrective effect of the suspension of the G. lucidum powdered mycelium on carbohydrate and lipid metabolism, which was directly proportional to the duration of administration.
In Situ ATR and DRIFTS Studies of the Nature of Adsorbed CO2 on Tetraethylenepentamine Films (2014)

CO2 adsorption/desorption onto/from tetraethylenepentamine (TEPA) films of 4, 10, and 20 μm thicknesses were studied by in situ attenuated total reflectance (ATR) and diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) techniques under transient conditions. Molar absorption coefficients for adsorbed CO2 were used to determine the CO2 capture capacities and amine efficiencies (CO2/N) of the films in the DRIFTS system. Adsorption of CO2 onto surface and bulk NH2 groups of the 4 μm film produced weakly adsorbed CO2, which can be desorbed at 50 °C by reducing the CO2 partial pressure. These weakly adsorbed CO2 exhibit low ammonium ion intensities and could be in the form of ammonium-carbamate ion pairs and zwitterions. Increasing the film thickness enhanced the surface amine-amine interactions, resulting in strongly adsorbed ion pairs and zwitterions associated with NH and NH2 groups of neighboring amines. These adsorbed species may form an interconnected surface network, which slowed CO2 gas diffusion into and diminished access of the bulk amine groups (or amine efficiency) of the 20 μm film by a minimum of 65%. Desorption of strongly adsorbed CO2 comprising the surface network could occur via dissociation of NH3(+)/NH2(+)···NH2/NH ionic hydrogen bonds beginning from 60 to 80 °C, followed by decomposition of NHCOO(-)/NCOO(-) at 100 °C. These results suggest that faster CO2 diffusion and adsorption/desorption kinetics could be achieved by thinner layers of liquid or immobilized amines.
ADVANCES IN PHARMACOTHERAPY OF TUBERCULOSIS. (2017)

Tuberculosis remains a growing threat of infectious diseases of twenty-first century. An attempt to find new antituberculosis agents was made especially to treat multidrug-resistant and extensively drug-resistant tuberculosis. One of the most promising drugs is bedaquiline - a new drug approved by Food and Drug Administration (FDA) and by the European Union countries. This compound is intended to treat multidrug-resistant pulmonary tuberculosis in adult patients in combination regimens in case of impossibility of using other drugs. This paper is also focused on some interesting molecules in treating multidrug-resistant tuberculosis which are currently tested in clinical studies: delamanid (dihydro-nitroimidazooxazole derivative, phase III), AZD5847 (oxazolidinone derivative, phase II), pretomanid (nitroimidazole derivative, phase III), sutezolid (oxazolidinone derivative, phase II) and SQ109 (ethambutol analogue, phase II) and some prospective molecules at the level of preclinical studies e.g., CPZEN-45, SQ609 and SQ641.
Radiation effects in space, nuclear power, and accelerators: impact on optics and light sensors (1997)

The degradation of space photosensors and optical devices in several radiation environments is reviewed. The effects are of concern to designers of spacecraft and ground-based systems dedicated to observation, inspection and other practical tasks. Design and prediction methods can be developed which make observation systems more tolerant to radiation effects. The methods for predicting radiation effects in light sensors, phosphors and optics are common to high-radiation in space and on the ground. In all cases, the creation of defects and the trapping of charge in silicon, insulators and transparent materials and the associated hardened technologies (such as hardened silicon, hardened oxide films, hardened fibres and ultrapure scintillators) are discussed and instruments for the measurement of radiation dose and silicon defect creation in orbit are described.
Background Modeling with Extracted Dynamic Pixels for Pumping Unit Surveillance (2018)

Background modeling plays an important role in the application of intelligent video surveillance. Researchers have presented diverse approaches to support the development of dynamic background modeling. However, in the case of pumping unit surveillance, traditional background modeling methods often mistakenly detect the periodic rotational pumping unit as the foreground object. To address this problem here, we propose a novel background modeling method for foreground segmentation, particularly in dynamic scenes that include a rotational pumping unit. In the proposed method, the ViBe method is employed to extract possible foreground pixels from the sequence frames and then segment the video image into dynamic and static regions. Subsequently, the kernel density estimation (KDE) method is used to build a background model with dynamic samples of each pixel. The bandwidth and threshold of the KDE model are calculated according to the sample distribution and extremum of each dynamic pixel. In addition, the strategy of sample adjustment combines regular and real-time updates. The performance of the proposed method is evaluated against several state-of-the-art methods applied to complex dynamic scenes consisting of a rotational pumping unit. Experimental results show that the proposed method is available for periodic object motion scenario monitoring applications.
In vivo quantification and perturbation of Myc-Max interactions and the impact on oncogenic potential (2014)

The oncogenic bHLH-LZ transcription factor Myc forms binary complexes with its binding partner Max. These and other bHLH-LZ-based protein-protein interactions (PPI) in the Myc-Max network are essential for the physiological and oncogenic activities of Myc. We have generated a genetically determined and highly specific protein-fragment complementation assay based on Renilla luciferase to analyze the dynamic interplay of bHLH-LZ transcription factors Myc, Max, and Mxd1 in vivo. We also applied this PPI reporter to quantify alterations of nuclear Myc-Max complexes in response to mutational events, competitive binding by the transcriptional repressor Mxd1, or perturbations by small-molecule Myc inhibitors, including recently identified potent PPI inhibitors from a Kröhnke pyridine library. We show that the specificity of Myc-Max PPI reduction by the pyridine inhibitors directly correlates with their efficient and highly specific potential to interfere with the proliferation of human and avian tumor cells displaying deregulated Myc expression. In a direct comparison with known Myc inhibitors using human and avian cell systems, the pyridine compounds reveal a unique inhibitory potential even at sub-micromolar concentrations combined with remarkable specificity for the inhibition of Myc-driven tumor cell proliferation. Furthermore, we show in direct comparisons using defined avian cell systems that different Max PPI profiles for the variant members of the Myc protein family (c-Myc, v-Myc, N-Myc, L-Myc) correlate with their diverse oncogenic potential and their variable sensitivity to the novel pyridine inhibitors.
Nonlinear all-optical GaN∕AlGaN multi-quantum-well devices for 100Gb∕s applications at λ=1.55μm (2005)

Using quantum-mechanical analysis, a strain-balanced stack of coupled GaN∕AlGaN quantum wells has been engineered for bandwidth-optimized all-optical switching at low switching powers. Intersubband transitions between three conduction subbands provide the basis for the large, fast, nonlinear optical response. Optimized performance for a given symbol rate is obtained by engineering the response time and nonlinear phase shift.
Monoclonal Endothelial Cells in Appetite Suppressant–associated Pulmonary Hypertension (1998)

Anorexigens such as aminorex fumarate and dexfenfluramine are associated with the development of severe pulmonary hypertension (PH), which clinically and histopathologically is considered indistinguishable from idiopathic or primary pulmonary hypertension (PPH). For the current study, we asked whether anorexigen-associated PH is characterized by monoclonal pulmonary endothelial cell proliferation (such as in PPH) or, alternatively, is associated with a polyclonal endothelial cell proliferation as found in secondary PH. Analysis of clonality by the human androgen receptor assay was performed in microdissected endothelial cells of plexiform lesions of two patients with anorexigen-associated PH. The four plexiform lesions of Patient 1 and the six of Patient 2 with anorexigen-associated PH exhibited a monoclonal expansion of pulmonary endothelial cells, with a mean clonality ratio of 0.03 +/- 0.01 SE. Our results indicate that appetite suppressant-associated PH is identical to PPH not only in clinical and histopathologic features but also, at a molecular level, in terms of the monoclonal nature of the endothelial cell proliferation. The anorexigens may accelerate the growth of pulmonary endothelial cells in patients with predisposition to develop PPH.
CD49a mediates cutaneous resident memory CD8+ T cell persistence and response (2020)

Abstract Resident memory CD8+ T cells (TRM) persist at sites of previous infection where they provide rapid local protection against pathogen challenge. CD8+ TRM expressing the a1 chain (CD49a) of integrin VLA-1 have been identified within sites of resolved skin infection as well as in vitiligo lesions. This study examines the signals that regulate CD8+ T cell CD49a expression and its requirement for cutaneous TRM formation and response. We demonstrate that CD49a was expressed early following T cell activation in vivo, and that TGF-b as well as IL-12 induced CD49a expression by CD8+ T cells in vitro. Despite this rapid expression, CD49a was not required for the generation of a primary CD8+ T cell response to cutaneous herpes simplex virus (HSV) infection. Rather, CD49a mediated epidermal CD8+ TRM interaction with the extracellular matrix, supported CD8+ TRM persistence within the skin, and increased the frequency of CD8+ TRM that secrete IFN-g following local antigen challenge. Thus, our results suggest CD49a promotes optimal cutaneous CD8+ TRM-mediated immunity.
On real-time and causal secure source coding (2012)

We investigate two source coding problems with secrecy constraints. In the first problem we consider real-time fully secure transmission of a memoryless source. We show that although classical variable-rate coding is not an option since the lengths of the codewords leak information on the source, the key rate can be as low as the average Huffman codeword length of the source. In the second problem we consider causal source coding with a fidelity criterion and side information at the decoder and the eavesdropper. We show that when the eavesdropper has degraded side information, it is optimal to first use a causal rate distortion code and then encrypt its output with a key.
Permeability of Membrane to Potassium in Hypochromic Red Cells with Different Specific Density (1977)

In hypochromic anaemias (heterozygous beta-thalassaemia and iron deficiency anaemia) ligher red cells lose more K+ than heavier ones, following incubation at 37 degrees C for 24 h. Both in the light and heavy fractions two subpopulations of cells with different permeability to K+ can be separated by a new centrifugation after incubation. On the basis of the results, a relationship between K+ permeability and probability of survival in hypochromic cells is suggested.
Lipid particle composition of the yeast Yarrowia lipolytica depends on the carbon source (2006)

Lipid particles (LP) of all types of cells are a depot of neutral lipids. The present investigation deals with the isolation of LP from the yeast Yarrowia lipolytica and the characterization of their lipid and protein composition. Properties of LP varied depending on the carbon source. LP from glucose-grown cells revealed a mean diameter of 650 nm with a hydrophobic core mainly formed of triacylglycerols (TAG) and a minor amount of steryl esters (SE). Oleic acid was the major fatty acid species esterified in LP. When cells were grown on oleic acid, LP size increased 3.8-fold, the particles exhibited a significantly lower ratio of TAG to SE, and the relative amount of oleic acid in LP lipids increased compared to cells grown on glucose. Analysis of LP proteins revealed an increasing number of polypeptides when cells were shifted from glucose- to oleic acid-containing medium. Twenty-one major LP proteins were identified under both growth conditions, and additional nine polypeptides were specific for growth on oleic acid. Identification of these proteins by MS and comparison of the deduced ORFs to those from Saccharomyces cerevisiae revealed that most proteins of Y. lipolytica LP are involved in lipid metabolism. LP proteins specific for growth on oleic acid are also enzymes involved in lipid metabolism, but some of them are also components of the intracellular traffic machinery. Thus, proteom analysis of LP proteins suggests involvement of this compartment in different cell biological processes.
Panel A: Comparative analysis of splicing site sequences in exon 32, 33, Δ33 and 34 flanking exon-intron junctions as well as prediction of impact of SNP32 (c (2011)

<b>Copyright information:</b>Taken from "Mutation analysis and characterization of ATR sequence variants in breast cancer cases from high-risk French Canadian breast/ovarian cancer families"BMC Cancer 2006;6():230-230.Published online 29 Sep 2006PMCID:PMC1599749.5739-4del9+T) on exon 34 acceptor site. Panel B: Comparative analysis of splicing site sequences in exon 41, insΔInt41 and exon 42 flanking exon-intron junctions as well as prediction of impact of SNP37 (c.7041+8G/A) on exon 41 donor site. Splice Site Prediction Program using Neural Network (SSPNN) score values are indicated in parenthesis below each sequence. Exonic nucleotides are represented by uppercase letters while intronic sequences are represented by lowercase letters. m = c or a, r = a or g, y = t or c and n = any nucleotide. N.A. = value not available. Consensus sequences of acceptor and donor sites were described by Burge et al. 1999 [84].
A note on utilising binary features as ligand descriptors (2015)

It is common in cheminformatics to represent the properties of a ligand as a string of 1's and 0's, with the intention of elucidating, inter alia, the relationship between the chemical structure of a ligand and its bioactivity. In this commentary we note that, where relevant but non-redundant features are binary, they inevitably lead to a classifier capable of capturing only a linear relationship between structural features and activity. If, instead, we were to use relevant but non-redundant real-valued features, the resulting predictive model would be capable of describing a non-linear structure-activity relationship. Hence, we suggest that real-valued features, where available, are to be preferred in this scenario.
Development of a 3D optical imaging system for in vivo detection of bioluminescence (2002)

A 3D optical imaging system has been developed at Xenogen Corporation for detection of bioluminescence in small mammals such as mice. We describe the instrumentation and algorithms for photon transport. Images of tissue phantoms and bioluminescent mice will be presented.
2LG-6 : Bioelastomers, 3D printing and their diverse applications (2019)

Biodegradable and biocompatible elastomers (bioelastomers) especially the thermoset ones can mimic the mechanical properties of soft tissues, and sustain and recover from various deformations when implanted in a mechanically dynamic environment in the body. 3D printing offers great power to customize sophisticated constructs for a myriad of applications. However, many thermosets require a long-term curing at harsh conditions, which are not compatible with rapid 3D printing processing. 3D printing thermosets remains a challenge. Poly(glycerol sebacate) (PGS) is a representative of thermoset bioelastomers and has been widely used. However, curing of PGS usually requires high temperature and high vacuum. The limited availability of processing methods for PGS greatly restricts the structural design freedom and its further applications. Here, we develop a novel and general strategy to 3D print thermosets including PGS and demonstrated their diverse applications.
Teaching for multi-fingered robots based on motion intention in virtual reality (2002)

We present teaching for multi-fingered robots based on motion intention in virtual reality. In motion intention analysis, motion is divided into plural primitive motions, those unnecessary for executing the task are deleted, and the remainder are represented by a smooth time function. Segmentation is made using 3D motion measurement of human and virtual objects and virtual reaction generated by the hand of an operator using a force-feedback glove. Analyzed motion is represented by human motion commands. A robot teaching command for the object coordinate frame is generated from a human motion command. Experimental results of a pick-and-place task verify the feasibility of proposed robot teaching.
Testing Defects in Scan Chains (1995)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Efficient localization in mobile wireless sensor networks (2006)

The proposed DRL is a distributed range-free localization approach. In order to save communication cost in localization, DRL reduces information flooding among nodes by dynamically changing each seed's flooding-hop to limit seed flooding in a local area; however, it still maintains the whole coverage. In addition, DRL allows all the nodes mobile and moving freely, while there is only a limited fraction of nodes having self-positioning capability (called seeds). Moreover, DRL can adapt to low or high node density, because of its dynamic seed flooding and robust triangulation. Dynamic seed flooding is to change flooding coverage according to each seed's surrounding node density. Robust triangulation allows the cases of insufficiency of reference nodes. We have evaluated DRL and MCL. Simulation results have shown that the location accuracy of DRL is 26% higher than that of MCL. With mobile positioning, DRL is suitable for applications, such as navigation systems using e-map and community health-care systems, in outdoor environments.
Predicting Drying Performance of Osmotically Treated Heat Sensitive Products Using Artificial Intelligence (2021)

The main goal of this research is to develop and apply a robust Artificial Neural Networks (ANNs) model for predicting the characteristics of the osmotically drying treated potato and apple samples as a model heat-sensitive product in vacuum contact dryer. Concentrated salt and sugar solutions were used as the osmotic solutions at 27C. Series of experiments were performed at various temperatures of 35C, 40C, and 55C for conduction heat input under vacuum ( −760 mm Hg) condition. Some experiments were also performed in a pure vacuum without heat addition. Dimensionless moisture content (DMC), effective moisture diffusivity, and mass flux were considered as the performance parameters in this study. Results revealed that the osmotic dehydration using a concentrated sugar solution shows a higher reduction in the initial moisture loss of 19.87% compared to 5.3% in the salt solution. Furthermore, a significant enhancement of drying performance of about 27% in DMC was observed for both samples at vacuum and 40C compared to pure vacuum drying conditions. Using the experimental data, a robust artificial neural network (ANN) was proposed to describe the osmotic dehydration’s behavior on the drying process. The ANN model outputs are the dimensionless moisture contents (DMC), the diffusivity, and the mass flux. Whereas the ANN inputs were the drying time, the percent of sugar solution, and the percent of salt solution. For the ANN apple’s model, the minimum root mean square error (RMSE) values were 0.0261, 0.0349 and 0.0406, for DMC, diffusivity, and mass flux, respectively. Whereas the best correlation coefficients of the above three parameters’ determination values were 0.9909, 0.9867 and 0.9744, respectively. For the ANN potato’s model, the minimum RMSE values were 0.0124, 0.0140 and 0.0333, for DMC, diffusivity, and mass flux, respectively. And the best correlation coefficients of the parameters’ values were found 0.9969, 0.9968 and 0.9736, respectively. Accordingly, the ANN model’s prediction has a perfect agreement with the experimental dataset, which confirmed the ANN model’s accuracy.
T-LAK Cell-originated Protein Kinase (TOPK) Phosphorylation of MKP1 Protein Prevents Solar Ultraviolet Light-induced Inflammation through Inhibition of the p38 Protein Signaling Pathway (2011)

Solar UV radiation is a major environmental factor that causes DNA damage, inflammation, and even skin cancer. T-LAK cell-originated protein kinase (TOPK) is expressed widely in both normal and cancer cells and functions to inhibit apoptosis and promote carcinogenesis. However, its function in inflammation is not known. The p38 MAPK signaling pathway plays an important role in solar UV light-induced inflammation. In this study, we found that TOPK negatively regulated the activity of p38α by phosphorylating the p38α-specific phosphatase MKP1 and enhancing the stability of MKP1. Notably, the absence of TOPK in mice resulted in a striking increase in skin inflammation. Therefore, we conclude that TOPK has a protective function in solar UV light-induced inflammation.
ChemInform Abstract: Liquidus Projection and Isothermal Section at 650 °C of Ternary Co—Sb—Ga System. (2015)

Abstract Both, alloys quenched from the molten state with compositions of the entire Co—Sb—Ga regime and alloys equilibrated at 650 °C with compositions in the CoSb 3 —CoGa—Ga—Sb regime are prepared and analyzed.
Adjunctive local antibiotic therapy in the treatment of peri‐implantitis II: clinical and radiographic outcomes (2007)

Non-surgical mechanical treatment of peri-implantitis lesions with adjunctive local delivery of microencapsulated minocycline led to positive effects on clinical parameters up to 12 months.