gebhart/patrepeval huggingface dataset:
The Relationship Between Cow’s Milk Exposure and Type 1 Diabetes (1996)

Environmental factors are important for the development of Type 1 diabetes mellitus. They likely account for changes in the incidence of this disease over time, as well as the well-documented differences in incidence in ethnically and genetically similar people living in different parts of the world. There is a relationship between early cow's milk exposure and the development of Type 1 diabetes in humans, and between early cow's milk exposure and the development of autoimmune diabetes in rodent models of Type 1 diabetes. Moreover, some immunological studies have suggested a possible mechanism whereby exposure to cow's milk protein could result in beta-cell directed autoimmunity and subsequent Type 1 diabetes. Although provocative, the existence of alternative explanations for these epidemiological and biological observations, suggest that the data are insufficient to conclude that the observed associations represent causal relationships or to mandate changes in recommendations for infant feeding. The question of whether or not avoidance of cow's milk protein in infancy will prevent Type 1 diabetes can, however, be tested in an international randomized clinical trial of infant diets, which is currently under review.
Spatial Topology Graphs for Feature-Minimal Correspondence (2007)

Multiview image matching methods typically require feature point correspondences. We propose a novel spatial topology method that represents the space with a set of connected projective invariant features. Typically, isolated features, such as corners, cannot be matched reliably. Hence, limitations are imposed on viewpoint changes, or projective invariant descriptions are needed. The fundamental matrix is discovered using stochastic optimization requiring a large number of features. In contrast, our enhanced feature set models connectivity in space, forming a unique configuration that can be matched with few features and over large viewpoint changes. Our features are derived from edges, their curvatures, and neighborhood relationships. A probabilistic spatial topology graph models the space using these features and a second graph represents the neighborhood relationships. Probabilistic graph matching is used to find feature correspondences. Our results show robust feature detection and an average 80% discovery rate of feature matches.
Boron diffusion in silicon devices (2023)

Disclosed are various embodiments that include a process, an arrangement, and an apparatus for boron diffusion in a wafer. In one representative embodiment, a process is provided in which a boric oxide solution is applied to a surface of the wafer. Thereafter, the wafer is subjected to a fast heat ramp-up associated with a first heating cycle that results in a release of an amount of boron for diffusion into the wafer.
Clinical Outcomes and Correlates of TP53 Mutations and Cancer (2009)

The initial observation that p53 accumulation might serve as a surrogate biomarker for TP53 mutation has been the cornerstone for vast translational efforts aimed at validating its clinical use for the diagnosis, prognosis, and treatment of cancer. Early on, it was realized that accurate evaluation of p53 status and function could not be achieved through protein-expression analysis only. As our understanding of the p53 pathway has evolved and more sophisticated methods for assessment of p53 functional integrity have become available, the clinical and molecular epidemiological implications of p53 abnormalities in cancers are being revealed. They include diagnostic testing for germline p53 mutations, and the assessment of selected p53 mutations as biomarkers of carcinogen exposure and cancer risk and prognosis. Here, we describe the strengths and limitations of the most frequently used techniques for determination of p53 status in tumors, as well as the most remarkable latest findings relating to its clinical and epidemiological value.
Screening for Cervical Cancer (1990)

Indirect evidence indicates that cervical cancer screening should reduce the incidence and mortality of invasive cervical cancer by about 90%. In the absence of screening, a 20-year-old average-risk woman has about a 250 in 10,000 chance of developing invasive cervical cancer during the rest of her life, and about a 118 in 10,000 chance of dying from it. Screening at least every 3 years from 20 to 75 years of age will decrease these probabilities by about 215 in 10,000 and 107 in 10,000, respectively, and will increase a 20-year-old woman's life expectancy by about 96 days. The particular age at which screening is begun (for example, 17 or 20 years), the requirement of several initial annual examinations before reducing the frequency, and screening every 1 or 2 years compared with every 3 years improves the effectiveness by less than 5%. Screening is recommended at least every 3 years from about age 20 to about age 65 years.
206401 Experimental Realization of System-Level Vibration by Use of a Single Component Based on a Virtual Boundary Condition Concept (2011)

A complex system such as a vehicle consists of many components, and system-level vibration is conducted when all components are available. In order to shorten the development time, a virtual boundary condition concept is proposed in which only a single component is used to be excited by actuators that provide appropriate interface forces from the other components. The method is verified by a simple numerical model and then applied to an actual HVAC.
Resonant absorption of terahertz electromagnetic waves by heated electrons in AlGaAs/GaAs heterostructures (1996)

In this letter, we propose a mechanism which may cause a strong absorption of terahertz (THz) electromagnetic radiation in AlGaAs/GaAs-based two-dimensional semiconductor systems. In such systems, the rate of electronic transitions via hot electrons interacting with impurities and phonons is on the scale of 1012 s−1 so that the THz radiation will modify strongly the processes of electron momentum and energy relaxation and, consequently, a resonant absorption of the THz electromagnetic wave may occur. We find that in these sample systems, the absorption of the electromagnetic radiation at different frequencies can be tuned by heating the electrons to different temperatures. Our results can be used for understanding and interpreting the experimental results reported very recently.
The Normal Vaginal Flora, H2O2-Producing Lactobacilli, and Bacterial Vaginosis in Pregnant Women (1993)

In this study of the vaginal flora of 171 pregnant women in labor at term, the flora was categorized as normal (Lactobacillus predominant), intermediate, or representative of bacterial vaginosis (BV) on the basis of a vaginal smear. BV was diagnosed in 39 women (23%); the vaginal flora was classified as normal in 50% of cases and as intermediate in 27%. H2O2-producing lactobacilli were recovered from 5% of women with BV, 37% of those with an intermediate flora, and 61% of those with a normal flora. H2O2-negative lactobacilli were equally frequent (57%-65%) in all three groups. The microorganisms most frequently recovered from women with BV included Gardnerella vaginalis, Prevotella bivia/disiens, Bacteroides ureolyticus, Prevotella corporis/Bacteroides levii, Fusobacterium nucleatum, Mobiluncus species, Peptostreptococcus prevotii, Peptostreptococcus tetradius, Peptostreptococcus anaerobius, viridans streptococci, Ureaplasma urealyticum, and Mycoplasma hominis (P < .05 for each). The presence of all but three of these organisms was inversely related to vaginal colonization by H2O2-producing lactobacilli; the exceptions were B. ureolyticus, F. nucleatum, and P. prevotii. Other microorganisms were equally frequent among women with and without BV. We conclude that specific groups of anaerobes are associated with BV in this population and that a strong association exists between species associated with BV and those inhibited by H2O2-producing lactobacilli.
Effects of Composition and Additives on Water Durability in V<sub>2</sub>O<sub>5</sub>-P<sub>2</sub>O<sub>5</sub> Glass System (1989)

V2O5-P2O5 glasses containing large amounts of V2O5 are known to have relatively low transformation and deformation temperatures, in spite of their low thermal expansion coefficients. However, poor water durability and strong devitrifying tendency prevent these glasses from being used as bonding glass. To improve these properties, the effects of composition and additives on the glass properties were studied, and the following results were obtained.(1) An increase in P2O5 content improved the water durability and restrained the tendency of devitrification, while the transformation and deformation temperatures increased.(2) On the other hand, addition of a small amount of Sb2O3 or PbO improved the water durability without affecting other properties of glasses.(3) Infrared spectrum analysis confirmed that the glass was transformed from layered into network structures with increasing P2O5 content or by addition of Sb2O3 or PbO. The improved water durability was explained by the network structure which prohibits the water penetration into glasses.
Commensal Microbiota and CD8+ T Cells Shape the Formation of Invariant NKT Cells (2009)

Commensal bacteria play an important role in formation of the immune system, but the mechanisms involved are incompletely understood. In this study, we analyze CD1d-restricted invariant NKT (iNKT) cells in germfree mice and in two colonies of C57BL/6 mice termed conventional flora and restricted flora (RF), stably bearing commensal microbial communities of diverse but distinct composition. In germfree mice, iNKT cells were moderately reduced, suggesting that commensal microbiota were partially required for the antigenic drive in maintaining systemic iNKT cells. Surprisingly, even greater depletion of iNKT cell population occurred in RF mice. This was in part attributable to reduced RF levels of intestinal microbial taxa (Sphingomonas spp.) known to express antigenic glycosphingolipid products. However, memory and activated CD8(+) T cells were also expanded in RF mice, prompting us to test whether CD8(+) T cell activity might be further depleting iNKT cells. Indeed, iNKT cell numbers were restored in RF mice bearing the CD8alpha(-/-) genotype or in adult wild-type RF mice acutely depleted with anti-CD8 Ab. Moreover, iNKT cells were restored in RF mice bearing the Prf1(-/-) phenotype, a key component of cytolytic function. These findings indicate that commensal microbiota, through positive (antigenic drive) and negative (cytolytic depletion by CD8(+) T cells) mechanisms, profoundly shape the iNKT cell compartment. Because individuals greatly vary in the composition of their microbial communities, enteric microbiota may play an important epigenetic role in the striking differences in iNKT cell abundance in humans and therefore in their potential contribution to host immune status.
A thickness modulation effect of HfO2 interfacial layer between double-stacked Ag nanocrystals for nonvolatile memory device applications (2007)

This paper presents a detailed study on the effect of different thicknesses of HfO2 high-k interfacial layer between double-stacked layers of Ag nanocrystals formed by a chemical synthesis and thermal decomposition method. To confirm the formation and purity of the well-ordered Ag nanocrystals with a high density (2.7×1012cm−2), transmission electron microscopy and x-ray diffraction analysis were used. After fabricating metal-oxide-silicon structures with 2 and 6nm interfacial HfO2 and the double-stacked Ag nanocrystals, a program efficiency and retention time characteristics were investigated.
Anticancer Effect of Dye-sensitized TiO2 Nanocrystals by Polychromatic Visible Light Irradiation (2006)

Abstract TiO2 nanocrystalline particles with monolayer adsorption of chlorin e6 trisodium salt (dye-TiO2 particles) were administered into a cancer cell, murine thymic lymphoma (EL-4). Irradiation of the polychromatic light (550–750 nm) that excites chlorin e6 significantly damaged the EL-4 cells. A higher cell-killing effect was found for the dye-TiO2 particle than for the system using chlorin e6 alone.
Host Vesicle Fusion Protein VAPB Contributes to the Nuclear Egress Stage of Herpes Simplex Virus Type-1 (HSV-1) Replication (2019)

The primary envelopment/de-envelopment of Herpes viruses during nuclear exit is poorly understood. In Herpes simplex virus type-1 (HSV-1), proteins pUL31 and pUL34 are critical, while pUS3 and some others contribute; however, efficient membrane fusion may require additional host proteins. We postulated that vesicle fusion proteins present in the nuclear envelope might facilitate primary envelopment and/or de-envelopment fusion with the outer nuclear membrane. Indeed, a subpopulation of vesicle-associated membrane protein-associated protein B (VAPB), a known vesicle trafficking protein, was present in the nuclear membrane co-locating with pUL34. VAPB knockdown significantly reduced both cell-associated and supernatant virus titers. Moreover, VAPB depletion reduced cytoplasmic accumulation of virus particles and increased levels of nuclear encapsidated viral DNA. These results suggest that VAPB is an important player in the exit of primary enveloped HSV-1 virions from the nucleus. Importantly, VAPB knockdown did not alter pUL34, calnexin or GM-130 localization during infection, arguing against an indirect effect of VAPB on cellular vesicles and trafficking. Immunogold-labelling electron microscopy confirmed VAPB presence in nuclear membranes and moreover associated with primary enveloped HSV-1 particles. These data suggest that VAPB could be a cellular component of a complex that facilitates UL31/UL34/US3-mediated HSV-1 nuclear egress.
Epostane and Indomethacin Actions on Ovarian Kallikrein and Plasminogen Activator Activities during Ovulation in the Gonadotropin-Primed Immature Rat1 (1992)

Kallikrein and plasminogen activator (PA) are serine proteases that have been implicated in the ovulatory process. Epostane and indomethacin are anti-ovulatory agents that inhibit steroid and eicosanoid synthesis, respectively. This study examines the effects of these two anti-ovulatory agents on ovarian kallikrein and PA activities during ovulation. The proteases were assayed by their actions on chromogenic peptide substrates S-2266 and S-2251, respectively. The ovulatory process was induced in 25-day-old Wistar rats by giving them hCG (10 IU, s.c.) 2 days after the animals had been primed with eCG (10 IU, s.c.). Control animals ovulated approximately 60-70 ova/rat, with the first ova appearing in the oviducts at 10-12 h after hCG administration, and this was the same time ovarian kallikrein and PA activities reached a peak. When doses of epostane ranging from 0.1-5.0 mg/rat or doses of indomethacin ranging from 0.03 to 3.16 mg/rat were administered s.c. at 3 h after hCG, the two drugs inhibited ovulation and ovarian kallikrein and PA activities in a dose-dependent manner. However, the anti-ovulatory action of the two drugs was more closely correlated with suppression of kallikrein activity than with PA activity. Treatment of the animals with exogenous progesterone reversed the inhibitory action of epostane, but not of indomethacin. The results suggest that the increase in ovarian progesterone at the time of ovulation may influence ovarian kallikrein and PA activities.
Interface‐Driven Structural Distortions and Composition Segregation in Two‐Dimensional Heterostructures (2017)

Abstract The discovery of emergent phenomena in 2D materials has sparked substantial research efforts in the materials community. A significant experimental challenge for this field is exerting atomistic control over the structure and composition of the constituent 2D layers and understanding how the interactions between layers drive both structure and properties. While no segregation for single bilayers was observed, segregation of Pb to the surface of three bilayer thick PbSe–SnSe alloy layers was discovered within [(Pb x Sn 1− x Se) 1+δ ] n (TiSe 2 ) 1 heterostructures using electron microscopy. This segregation is thermodynamically favored to occur when Pb x Sn 1− x Se layers are interdigitated with TiSe 2 monolayers. DFT calculations indicate that the observed segregation depends on what is adjacent to the Pb x Sn 1− x Se layers. The interplay between interface‐ and volume‐free energies controls both the structure and composition of the constituent layers, which can be tuned using layer thickness.
Reductive Metabolism of AGE Precursors: A Metabolic Route for Preventing AGE Accumulation in Cardiovascular Tissue (2009)

Aldose reductase-catalyzed reduction is an important pathway in the endothelial and cardiac metabolism of AGE precursors, and it prevents AGE accumulation and atherosclerotic lesion formation.
A new artificial nerve graft containing rolled Schwann cell monolayers (2001)

This study hypothesized that introducing high numbers of Schwann cells in monolayers via a novel rolled graft architecture would promote robust nerve regeneration. The objective was to place adherent Schwann cells in artificial nerve grafts and to assess regeneration through the Schwann cell-laden grafts compared with that through acellular grafts and autografts. Schwann cells were isolated from neonatal Fisher rats. Small intestinal submucosa (SIS) was harvested from adult Fisher rats, cut into 7 mm x 8 cm pieces, and pinned out. Schwann cells were plated onto the strips, allowed to reach confluence, and subsequently rolled into a laminar structure and implanted across a 7-mm gap in the rat sciatic nerve (n = 12). Control animals received SIS conduits without Schwann cells (n = 11) or autograft repair (n = 12). At 10.5 weeks, functional regeneration through the Schwann cell-laden grafts, measured by both sciatic function index and extensor postural thrust testing, exceeded that through the cell-free grafts and approached that achieved through autografts. These results highlight the role of Schwann cells in nerve regeneration. Regenerative results approaching autograft levels in the Schwann cell-laden group suggest that this methodology may ultimately be useful in clinical nerve repair.
Thick silicon Hi-Rho CMOS with high red response (2022)

CMOS image sensors traditionally have used a pinned photodiode with a transfer gate to achieve low dark signal and noise. One drawback of the pinned photodiode is the inability to achieve good Modulation Transfer Function (MTF) as the sensor thickness is increased beyond epitaxial thicknesses greater than 10μm as required for higher red response. This is due to the pinned photodiode providing only a very small voltage to deplete the silicon, which results in significant lateral charge diffusion and poor resolution. The limitation in device thickness means that the QE at longer wavelengths (&gt;600nm) is limited for conventional CMOS pixel technologies. A way to increase the depletion depth is to apply a back bias from the rear of the device, however if one were to do this on standard CMOS image sensors then there would be significant leakage current between the back bias and components on the device causing it to not function. A new patented DDE (Deep Depletion Extension) implant helps diode depletion regions to merge laterally creating a “pinch-off” and prevent leakage from in-pixel transistors. This enables epitaxial thickness of up to 50μm to be fully depleted with negligible leakage. The CIS220 is a new ESA GSTP funded derivative of the CIS120 Capella Space Imager platform which incorporates this patented HiRho back bias structure allowing full depletion of the sensor thickness. This paper will present initial results from back-thinned CIS220 devices with 17μm and 33μm thicknesses and will explore the effect of the back bias on electro-optical test results.
Metastatic and unresectable biliary tract tumors: A single-center retrospective review. (2012)

e14733 Background: Biliary tract tumours are rare and often poor prognosis cancers that comprise cholangiocarcinomas, ampullary tumours and gallbladder cancers. Methods: Medical Electronic Records for patients diagnosed between January 2008 and December 2010 and treated at a medical oncology unit were reviewed, and clinical and epidemiological data for patients were retrieved. Results: We have found 28 patients with a distribution with a clear majority of men (60%), with a median age of 66 years (range 45-80).Patients were mostly metastatic (85%) at diagnosis and the majority of patients had intrahepatic cholangiocarcinoma (60%) as diagnosis and debuted with large intrahepatic masses and metastatic disease.Those with tumours arising outside the liver (40%) had obstructive jaundice (28%) or cholangitis (26%) at diagnosis and needed in most cases biliary stenting (33%).Six patients had PS2 at diagnosis and received gemcitabine monotherapy. Only one patient remaining progression free at 6 months and none of them received treatment at progression, the mean PFS was of 5.3 months and the OS was of 8.3 months.Of 22 patients with good performance status, 12 of them with a mean age of 60 years received polychemotherapy with GEMOX or CDDP-gem with PFS of 7. 3 months and OS of 12. 3 months.The other 10 patients (with a mean age of 65 years) received gemcitabine as monotherapy with a PFS of 7. 9 months and a OS of 11. 4 months.Eight patients were treated with second line therapy with no responses and a mean of PFS of 2 months, OS was not superior to patients who did not receive second line treatment. Conclusion: Our patients with biliary tract tumours had a mean progression free survival of 8.2 months and a mean overall survival of 12.3 months with 5 patients remaining progression free more than 20 months after beginning treatment. This survival data are compatible with those reported in recent clinical trials although we did not find improvements in survival with polychemotherapy and second line therapies. Conclusions: Taken as a whole our patients with biliary tract tumours had a mean progression free survival of 8.2 months and a mean overall survival of 12.3 months with 5 patients remaining progression free more than 20 months after beginning treatment.
The ESX-5 System of Pathogenic Mycobacteria Is Involved In Capsule Integrity and Virulence through Its Substrate PPE10 (2016)

Mycobacteria produce a capsule layer, which consists of glycan-like polysaccharides and a number of specific proteins. In this study, we show that, in slow-growing mycobacteria, the type VII secretion system ESX-5 plays a major role in the integrity and stability of the capsule. We have identified PPE10 as the ESX-5 substrate responsible for this effect. Mutants in esx-5 and ppe10 both have impaired capsule integrity as well as reduced surface hydrophobicity. Electron microscopy, immunoblot and flow cytometry analyses demonstrated reduced amounts of surface localized proteins and glycolipids, and morphological differences in the capsular layer. Since capsular proteins secreted by the ESX-1 system are important virulence factors, we tested the effect of the mutations that cause capsular defects on virulence mechanisms. Both esx-5 and ppe10 mutants of Mycobacterium marinum were shown to be impaired in ESX-1-dependent hemolysis. In agreement with this, the ppe10 and esx5 mutants showed reduced recruitment of ubiquitin in early macrophage infection and intermediate attenuation in zebrafish embryos. These results provide a pivotal role for the ESX-5 secretion system and its substrate PPE10, in the capsular integrity of pathogenic mycobacteria. These findings open up new roads for research on the mycobacterial capsule and its role in virulence and immune modulation.