gebhart/patrepeval huggingface dataset:
Kinetics of the reduction of alkyl halides by a chromium(II) macrocycle (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetics of the reduction of alkyl halides by a chromium(II) macrocycleAndreja Bakac, Vjera Butkovic, James H. Espenson, and Matko OrhanovicCite this: Inorg. Chem. 1993, 32, 25, 5886–5888Publication Date (Print):December 1, 1993Publication History Published online1 May 2002Published inissue 1 December 1993https://pubs.acs.org/doi/10.1021/ic00077a038https://doi.org/10.1021/ic00077a038research-articleACS PublicationsRequest reuse permissionsArticle Views54Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Water entry into astrocytes during brain edema formation (2008)

The process of brain edema formation has been studied extensively at the macroscopic level. In contrast, little is known about water fluxes and volume changes at the cellular level in the initial phase of brain edema. Insight in these "microscopic" events could pave the way for more efficient prevention and therapy. Here, we report measurements of brain cell volume responses recorded in vivo in a model of systemic hyponatremia. Transgenic mice expressing fluorescent proteins in astrocytes were subjected to hypo-osmotic stress and two photon laser scanning microscopy. Volume measurements of glial cells in the cerebellum and the visual cortex indicate that individual astrocytes undergo a position-dependent increase in cell volume by a factor of two or more during edema formation. Our data are the first to show that volume changes can be monitored at the cellular level in vivo and demonstrate that astrocytes are sites of water entry in the initial phase of brain edema formation. The uptake of water in astrocytes is likely to reflect the strong expression of aquaporin-4 in these cells.
Association of adverse events (AEs) with efficacy outcomes for cabozantinib (C) in patients (pts) with advanced hepatocellular carcinoma (aHCC) in the phase III CELESTIAL trial. (2019)

4088 Background: Class-specific AEs occurring with tyrosine kinase inhibitors have been associated with improved efficacy outcomes in several tumor types including aHCC. In the phase 3 CELESTIAL trial (NCT01908426), C, an inhibitor of VEGFR, MET, and AXL, improved overall survival (OS) and progression-free survival (PFS) vs placebo (P) in pts with previously treated aHCC. Here, we retrospectively evaluate the association of palmar-plantar erythrodysaesthesia (PPE) and hypertension (HTN) with OS and PFS for C in the CELESTIAL trial. Methods: 707 pts with aHCC were randomized 2:1 to receive 60 mg C or P once daily. Eligible pts had Child-Pugh score A, ECOG PS ≤1, must have received prior sorafenib, and could have received up to two prior regimens of systemic therapy for HCC. OS and PFS with C were evaluated for pts with any grade PPE or grade ≥3 HTN within the first 8 weeks of study treatment. Results: Overall, 374 (80%) pts in the C arm and 179 (76%) pts in the P arm completed ≥8 weeks of treatment. In the first 8 weeks, 188 (40%) of C-treated pts developed any grade PPE vs 11 (5%) of P-treated pts, and 61 (13%) of C-treated pts developed grade ≥3 HTN vs 3 (1%) of P-treated pts. Median OS with C was 14.4 mo for pts with any grade PPE vs 8.4 mo for pts without PPE (HR 0.59, 95% CI 0.47-0.74), and median PFS with C was 6.5 mo vs 3.7 mo, respectively (HR 0.63, 95% CI 0.51-0.78). Median OS with C was 16.1 mo for pts with grade ≥3 HTN vs 9.5 mo for pts without grade ≥3 HTN (HR 0.56, 95% CI 0.39-0.80), and median PFS with C was 7.4 mo vs 4.4 mo, respectively (HR 0.59, 95% CI 0.43-0.82). Some imbalances in baseline characteristics were present. Pts with PPE had better ECOG PS (60% vs 47% ECOG 0), better liver function (48% vs 34% ALBI grade 1), and less macrovascular invasion (24% vs 30%) than those without. Likewise, pts with grade ≥3 HTN had better ECOG PS (61% vs 51% ECOG 0), better liver function (56% vs 37% ALBI grade 1), and less macrovascular invasion (20% vs 29%) than those without. Conclusions: The development of PPE or grade ≥3 HTN with C was associated with prolonged OS and PFS in pts with previously treated aHCC although some imbalances in baseline characteristics between comparator groups were present. Clinical trial information: NCT01908426.
A mathematical micturition model to restore simple flow recordings in healthy and symptomatic individuals and enhance uroflow interpretation (2000)

We describe a model and report a new method to extract quantified data from the simple analysis of whole uroflow curves in healthy and symptomatic individuals. Recorded flow curves were compared with the curves theoretically predicted from a mathematical micturition model. This model was developed by relating each physiological event occurring during micturition to a set of mathematical equations. Due to improvements in speed of computer calculations, a very fast and adaptable mathematical micturition model became available. A total of 302 uroflow curves from 142 patients (61 men and 81 women) were studied. The control group consisted of seven men and 25 women; the symptomatic groups comprised 54 men and 56 women. The mathematical model was applied to analyze all the recorded curves. For patients with lower urinary tract symptoms, specific modelization parameters were introduced according to the clinical condition to be tested. Using two compulsory (patient sex and voided volume) and two optional parameters (clinical condition and urethral catheter size), our mathematical model was able to produce uroflow calculated curves similar to observed curves. In the control group, the calculated and recorded uroflow curves were found to superimpose with an impressive accuracy, i.e., a quadratic error <1%. Test-re-test studies gave the same determination of the specific parameters. In benign prostatic hyperplasia patients, the compressive effect on both prostatic urethra and bladder neck was separately identified. The same intra-individual values were found at 2-week intervals in the group with no treatment (P = no significance), whereas after 3 months of treatment with an alpha-blocker, a decrease in values was noted in responder patients (P < 0.001). In women with various degrees of cystocele, a constrictive effect was identified and found to be identical for successive flows during the same urodynamic testing. This large prospective study demonstrated the relevance of a sophisticated, heavily computerized micturition model, taking into account physiological voiding parameters, to the study of flow in healthy individuals and patients with benign prostatic hyperplasia or cystocele. Curve-fitting led to the determination of critical events during flow such as break point and plateau phase. Determination of these events may enhance uroflow interpretation by providing additional information on the detrusor function. Neurourol. Urodynam. 19:153-176, 2000.
Wideband energy harvesting using a combination of an optimized synchronous electric charge extraction circuit and a bistable harvester (2013)

International audience
Effect of Growth Hormone on Sodium Transport and Osmotic Water Flow Across Toad Skin (1974)

In order to determine the mode by which growth hormone causes sodium and water retention in animals, its action was studied using isolated toad skin. Within minutes, after adding ovine or bovine growth hormone to the medium bathing the inside of the isolated skin, there was an increase in sodium transport and osmotic water movement across the skin. Pretreatment of skins with growth hormone or antidiuretic hormone abolished or reduced stimulation of sodium transport by the other hormone. Similarities between the actions of these two hormones suggested a common mode of action. Demonstration of significant pressor activity in the ovine and bovine growth hormone preparations and lack of stimulation of sodium transport or osmotic water flow across isolated toad skin by highly purified growth hormone lead us to conclude that the sodium and water retaining actions of ovine and bovine growth hormone may be due to contamination with neurohypophysial hormones.
Treatment of Progressive Hemifacial Atrophy by Cartilage Graft and Free Adipofascial Flap Combined with Three-Dimensional Planning (2023)

Therapeutic, IV.
Weakly hard real-time systems (2001)

In a hard real-time system, it is assumed that no deadline is missed, whereas, in a soft or firm real-time system, deadlines can be missed, although this usually happens in a nonpredictable way. However, most hard real-time systems could miss some deadlines provided that it happens in a known and predictable way. Also, adding predictability on the pattern of missed deadlines for soft and firm real-time systems is desirable, for instance, to guarantee levels of quality of service. We introduce the concept of weakly hard real-time systems to model real-time systems that can tolerate a clearly specified degree of missed deadlines. For this purpose, we define four temporal constraints based on determining a maximum number of deadlines that can be missed during a window of time (a given number of invocations). This paper provides the theoretical analysis of the properties and relationships of these constraints. It also shows the exact conditions under which a constraint is harder to satisfy than another constraint. Finally, results on fixed priority scheduling and response-time schedulability tests for a wide range of process models are presented.
Frequency-Domain Data-Aided Channel Estimation for KSP-OFDM (2008)

In this paper, we propose a new low-complexity data-aided channel estimation algorithm for known symbol padding (KSP) OFDM. Besides the pilot symbols in the guard interval, additional pilots are put on some of the OFDM carriers. The received time-domain samples are first converted to the frequency domain, and the channel estimation is based on the observation of the pilot carriers only. The proposed estimator is compared to the subset estimator from [1]. Although performing slightly worse than the subset estimator at low SNR, the proposed estimator outperforms the subset estimator at high SNR, as the former does not suffer from an error floor in the MSE. The MSE resulting from the proposed estimator is inversely proportional to the number of pilot carriers and is independent of the FFT size, the pilot carrier positions and the used pilot sequence.
Sulfur dioxide oxidation and nitric oxide decomposition over copper oxide on ʏ-alumina sorbents/catalysts: an infrared diffuse reflectance study (1997)

Copper (II) oxide on ʏ-alumina sorbents/catalysts generated from the thermolysis of supported copper acetylacetonate complex, have shown potential for the possible removal of SO2and NO in a gas stream. These supported metal complexes were prepared by the non-aqueous impregnation of the catalyst precursor {CU(acac)2} on alumina. Diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) was used to investigate the nature of interaction between the support and the π-electron structure of the complex. SO2 adsorption in the absence of added oxygen produced aluminum sulfate species even at 30ºC on all sorbents. The formation of sulfates without added oxygen is suggested to be due to the high dispersion of the metal. Oxidation of chemisorbed SO2 species yielded a copper sulfate band at 1125cm-1. NO adsorption shows that the copper exists primarily as Cu2+ ions on the catalysts. The decomposition of NO is inferred via the formation of a copper-nitrito complex identified at 1628cm-1 absorption band. A sulfated surface appears to stabilize the cupric ions thereby enhancing the NO adsorption.
The treatment of refractory ischemic ventricular tachycardia by endoventricular patch plasty reconstruction of the left ventricle. (1997)

Although the endoventricular patch plasty technique was originally developed to improve the functional status of the left ventricle following resection of an aneurysm, it became apparent early on in our experience that the technique also cured most cases of ventricular tachycardia associated with these aneurysms. As a result, we began to include as a part of our preoperative work-up an electrophysiology study in which we attempted to induce ventricular tachycardia even if it had not occurred spontaneously. Using our standard surgical approach, plus the use of cryotherapy, we have now operated on 106 patients with either spontaneous or inducible ventricular tachycardia preoperatively in association with ventricular dyskinesia or akinesia. The operative mortality in this series of patients was 7.5%. Postoperatively, ventricular tachycardia could not be induced in 92% of the survivors and only 2 patients have had episodes of spontaneous ventricular tachycardia. Because this technique does not require any intraoperative electrophysiological mapping, we believe this to be an excellent surgical approach for patients with refractory ischemic ventricular tachycardia.
Embracing diversity and inclusivity in an academic setting: Insights from the Organization for Human Brain Mapping (2020)

Scientific research aims to bring forward innovative ideas and constantly challenges existing knowledge structures and stereotypes. However, women, ethnic and cultural minorities, as well as individuals with disabilities, are systematically discriminated against or even excluded from promotions, publications, and general visibility. A more diverse workforce is more productive, and thus discrimination has a negative impact on science and the wider society, as well as on the education, careers, and well-being of individuals who are discriminated against. Moreover, the lack of diversity at scientific gatherings can lead to micro-aggressions or harassment, making such meetings unpleasant, or even unsafe environments for early career and underrepresented scientists.At the Organization for Human Brain Mapping (OHBM), we recognized the need for promoting underrepresented scientists and creating diverse role models in the field of neuroimaging. To foster this, the OHBM has created a Diversity and Inclusivity Committee (DIC). In this article, we review the composition and activities of the DIC in order to inspire other organizations to implement similar initiatives. Activities of the committee over the past four years have included (a) creating a code of conduct, (b) providing diversity and inclusivity education for OHBM members, (c) organizing interviews and symposia on diversity issues, and (d) organizing family-friendly activities and providing child care grants during the OHBM annual meetings.We strongly believe that these activities have brought positive change within the wider OHBM community, improving inclusivity and fostering diversity while promoting rigorous, ground-breaking science. These positive changes could not have been so rapidly implemented without the enthusiastic support from the leadership, including OHBM Council and Program Committee, and the OHBM Special Interest Groups (SIGs), namely the Open Science, Student and Postdoc, and Brain-Art SIGs. Nevertheless, there remains ample room for improvement, in all areas, and even more so in the area of targeted attempts to increase inclusivity for individuals with disabilities, members of the LGBTQ+ community, racial/ethnic minorities, and individuals of various socioeconomic status.Here, we present an overview of the DIC’s composition, its activities, future directions and challenges. Our goal is to share our experiences with a wider audience to provide information to other organizations and institutions wishing to implement similar comprehensive diversity initiatives. We propose that scientific organizations can push the boundaries of scientific progress only by moving beyond existing power structures and by integrating principles of acceptance and inclusivity in their core values.
A new method of preparing monocyte suspensions from human whole blood. (1986)

A method of isolating monocytes from human whole blood is described. The technique is primarily based on simple centrifugation steps that follow Tylose-sedimentation as well as on the use of the new density gradient medium Nycodens. Counterflow centrifugation is not involved. The final monocyte suspension is free of platelets. The contaminating cells are predominantly lymphocytes. As a whole, the method is a modification of the Nycodens technique published by Boyum in 1983, which leads to a total elimination of platelet contamination in the final cell suspension.
Ultra-rapid, sensitive and specific digital diagnosis of HIV with a dual-channel SAW biosensor in a pilot clinical study (2018)

Despite widened access to HIV testing, around half of those infected worldwide are unaware of their HIV-positive status and linkage to care remains a major challenge. Current rapid HIV tests are typically analogue risking incorrect interpretation, no facile electronic data capture, poor linkage to care and data loss for public health. Smartphone-connected diagnostic devices have potential to dramatically improve access to testing and patient retention with electronic data capture and wireless connectivity. We report a pilot clinical study of surface acoustic wave biosensors based on low-cost components found in smartphones to diagnose HIV in 133 patient samples. We engineered a small, portable, laboratory prototype and dual-channel biochips, with in-situ reference control coating and miniaturised configuration, requiring only 6 µL plasma. The dual-channel biochips were functionalized by ink-jet printing with capture coatings to detect either anti-p24 or anti-gp41 antibodies, and a reference control. Biochips were tested with 31 plasma samples from patients with HIV, and 102 healthy volunteers. SH-SAW biosensors showed excellent sensitivity, specificity, low sample volumes and rapid time to result, and were benchmarked to commercial rapid HIV tests. Testing for individual biomarkers found sensitivities of 100% (anti-gp41) and 64.5% (anti-p24) (combined sensitivity of 100%) and 100% specificity, within 5 min. All positive results were recorded within 60 s of sample addition with an electronic readout. Next steps will focus on a smartphone-connected device prototype and user-friendly app interface for larger scale evaluation and field studies, towards our ultimate goal of a new generation of affordable, connected point-of-care HIV tests.
Seed productivity and germinability of various garlic clones collected in soviet central asia (1988)

departmental bulletin paper
Apelin promotes lymphangiogenesis and lymph node metastasis (2014)

Whereas the role of the G-protein-coupled APJ receptor and its ligand, apelin, in angiogenesis has been well documented, the ability of the apelin/APJ system to induce lymphangiogenesis and lymphatic metastasis has been largely unexplored. To this end, we first show that APJ is expressed in lymphatic endothelial cells (LECs) and, moreover, that it responds to apelin by activating the apelinergic signaling cascade. We find that although apelin treatment does not influence the proliferation of LECs in vitro, it enhances their migration, protects them against UV irradiation-induced apoptosis, increases their spheroid numbers in 3D culture, stimulates their in vitro capillary-like tube formation and, furthermore, promotes the invasive growth of lymphatic microvessels in vivo in the matrigel plug assay. We also demonstrate that apelin overexpression in malignant cells is associated with accelerated in vivo tumor growth and with increased intratumoral lymphangiogenesis and lymph node metastasis. These results indicate that apelin induces lymphangiogenesis and, accordingly, plays an important role in lymphatic tumor progression. Our study does not only reveal apelin as a novel lymphangiogenic factor but might also open the door for the development of novel anticancer therapies targeting lymphangiogenesis.
A Differential Geometry Approach for Change Detection in Medical Images (2017)

Change detection is of paramount importance in medical imaging, serving as a non-invasive quantifiable powerful tool in diagnosis and in assessment of the outcome of treatment of tumors. We present a new quantitative method for detecting changes in volumetric medical data and in clustering of anatomical structures, based on assessment of volumetric distortions that are required in order to deform a test three-dimensional medical dataset segment onto its previously-acquired reference, or a given prototype in the case clustering. Unlike the voxel-based classical techniques of shape comparison, our algorithm operates on tetrahedral meshes and can, therefore be applied on both closed, simply-connected, surfaces and in volumetric domains with more sophisticated boundaries.