gebhart/patrepeval huggingface dataset:
Mode & mechanism of low intensity pulsed ultrasound (LIPUS) in fracture repair (2016)

It has been 30years since the first level one clinical trial demonstrated low intensity pulsed ultrasound (LIPUS) could accelerate fracture repair. Since 1994 numerous investigations have been performed on the effect of LIPUS. The majority of these studies have used the same signal parameters comprised of an intensity of 30mW/cm(2) SATA, an ultrasound carrier frequency of 1.5MHz, pulsed at 1kHz with an exposure time of 20minutes per day. These studies show that a biological response is stimulated in the cell which produces bioactive molecules. The production of these molecules, linked with observations demonstrating the enhanced effects on mineralization by LIPUS, might be considered the general manner, or mode, of how LIPUS stimulates fractures to heal. We propose a mechanism for how the LIPUS signal can enhance fracture repair by combining the findings of numerous studies. The LIPUS signal is transmitted through tissue to the bone, where cells translate this mechanical signal to a biochemical response via integrin mechano-receptors. The cells enhance the production of cyclo-oxygenese 2 (COX-2) which in turn stimulates molecules to enhance fracture repair. The aim of this review is to present the state of the art data related to LIPUS effects and mechanism.
An Fc Double-Engineered CD20 Antibody with Enhanced Ability to Trigger Complement-Dependent Cytotoxicity and Antibody-Dependent Cell-Mediated Cytotoxicity (2017)

Combining glyco-engineering and protein engineering technologies offers the opportunity to simultaneously enhance ADCC and CDC activities of therapeutic antibodies. This approach may represent an attractive strategy to further improve antibody therapy of cancer and deserves further evaluation.
Predictive and corrective model for bulk heating distortion in photomasks (2000)

Finite element (FE) numerical models were proposed to simulate and predict substrate thermal expansion in photomask substrates and were found to be computationally expensive and dependent on the mask-writing strategy. The present work describes a newly developed model that predicts and corrects for the substrate heating effects in the photomask. This prosed model provides a practical way of predicting in-plane distortions during real-time patterning that is not limited to nay writing strategy or pattern density distribution. The main advantage of this model is that it significantly reduces the computational time by using the linear superposition theory. By adopting the concept of linear superposition, pattern placement errors of mask substrate scan be determined at any time during writing using lookup tables from precomputed FE models. IF the thermal distortion of the substrate at the time during writing using lookup tables from, precomputed FE models. IF the thermal distortion of the substrate at the time of writing is known, beam deflection can be introduced to correct for the distorted substrate. The result predicted by the linear superposition FE model showed a difference of less than 10 percent compared with those predicted using a real-time calculated Fe mode, in a worst case scenario. The accuracy of the linear superposition FE model was found to be partially dependent on the size of the simulated patterning field. The results presented in this paper illustrate the effect of other parameters on the performance of the newly developed model, such as the shape of the patterning fields and pattern coverage uniformity. The overview of this work focuses on fused silica mask substrate materials.
Elucidating the physical properties of the molybdenum oxide Mo4O11 and its tantalum substituted variant Mo2Ta2O11 (2020)

Abstract Although γ / η -Mo 4 O 11 and Mo 2 Ta 2 O 11 are used in a variety of industrial applications and can easily be synthesized in a chemical vapour transport (CVT) process or reactions in silica ampoules, respectively, only few data are available concerning their physical properties. In this paper, we further explore the properties of the three compounds with respect to their thermal and magnetic behavior, surface composition, and Raman spectroscopic properties.
Interventioneller Verschluss der tumorversorgenden A. cerebri posterior bei einem atypischem Plexuspapillom eines Frühgeborenen der 35. SSW (GG 2230g) (2007)

Einleitung: Vom Plexus chorideus ausgehende Tumore machen in der Pädiatrie ungefähr 2–3% der intracraniellen Neoplasien aus. Der Großteil der Plexustumore hat seinen Ursprung in den Seitenventrikeln oder dem 4. Ventrikel. Die Therapie erfolgt im Rahmen der SIOP-CPT Studie. Ist die primäre neurochirurgische Entfernung des Tumors nicht möglich oder die perioperative Blutungsgefahr zu groß, so stellt der interventionelle Verschluss des tumorversorgenden Gefäßes eine gute präoperative Alternative zur neoadjuvanten Chemotherapie dar. Fallbericht: Wir berichten über den Fall eines weiblichen Frühgeborenen von 35 + 1 SSW mit einem Geburtsgewicht von 2230g, welches mit einer großen, pränatal bereits diagnostizierten, Raumforderung im Bereich der rechten Schädelhemisphäre geboren wurde. Aufgrund rascher Größenprogredienz wurde die Geburt in der 35 SSW eingeleitet. Postnatal zeigte das Kind eine problemlose Adaptation. Im MRT zeigte sich ein intraventrikulärer Tumor von 7cm Durchmesser im rechten Seitenventrikel, welcher vaskulär über eine kompensatorisch erweiterte rechte A. choroidea posterior versorgt wurde. Das weitere Hirnparenchym stellte sich unauffällig dar. Zur Reduktion des perioperativen Blutungsrisikos erfolgte fünf Tage nach Geburt interventionell-angiographisch mittels Platzierung mehrerer Liquidcoils und Platinspiralen der komplette Verschluss des tumorversorgenden Blutgefäßes und somit die Devaskularisierung des Tumors. Am Folgetag konnte der Tumor neurochirurgisch ohne Blutungskomplikationen in toto reseziert werden. Die histologische Aufarbeitung ergab die Diagnose eines atypischen Plexuspapilloms (WHO Grad 2). Einen Monat nach Geburt konnte der Säugling nach Hause entlassen werden. MRT- Kontrolluntersuchungen zeigen bisher keinen Hinweis auf ein Tumorrezidiv. Schlussfolgerung: Der interventionelle Verschluss tumorversorgender Blutgefäße ist auch bei Frühgeborenen mit Plexuspapillom eine erfolgreiche Möglichkeit zur Reduktion des perioperativen Blutungsrisikos und zur Optimierung des Operationsergebnisses.
A tree-like nanoporous WO3 photoanode with enhanced charge transport efficiency for photoelectrochemical water oxidation (2015)

A tree-like nanoporous tungsten trioxide (WO<sub>3</sub>) photoanode that largely improves the photoelectrochemical water-oxidation performance was synthesized by a laser ablation method.
Cyclodextrins Exert a Ligand-like Current Inhibitory Effect on the KV1.3 Ion Channel Independent of Membrane Cholesterol Extraction (2021)

Cyclodextrins (CDs) are cyclic oligosaccharides capable of forming water-soluble complexes with a variety of otherwise poorly soluble molecules including cholesterol and different drugs. Consistently, CDs are widely used in research and clinical practice to deplete cholesterol from cellular membranes or to increase solubility and bioavailability of different pharmaceuticals at local concentrations in the millimolar range. Effects of CDs exerted on cellular functions are generally thought to originate from reductions in cholesterol levels. Potential direct, ligand-like CD effects are largely neglected in spite of several recent studies reporting direct interaction between CDs and proteins including AMP-activated protein kinase, β-amyloid peptides, and α-synuclein. In this study, by using patch-clamp technique, time-resolved quantitation of cholesterol levels and biophysical parameters and applying cholesterol-extracting and non-cholesterol-extracting CDs at 1 and 5 mM concentrations, we provide evidence for a previously unexplored ligand-like, cholesterol-independent current inhibitory effect of CDs on K<sub>V</sub>1.3, a prototypical voltage-gated potassium channel with pathophysiological relevance in various autoimmune and neurodegenerative disorders. Our findings propose that potential direct CD effects on K<sub>V</sub> channels should be taken into consideration when interpreting functional consequences of CD treatments in both research and clinical practice. Furthermore, current-blocking effects of CDs on K<sub>V</sub> channels at therapeutically relevant concentrations might contribute to additional beneficial or adverse effects during their therapeutic applications.
Design and Implementation of a Portable ID Management Framework for a Secure Virtual Machine Monitor (2007)

A commonly used virtual machine monitor (VMM) allows multiple operating systems to share physical hardware resources as virtual resources in a safe manner. It provides a strong isolation mechanism between virtual machines (VMs). In this paper, we state the importance of ID management for a security-purpose VMM system to enforce security policy on an end-user environment. We present a design of a portable ID management framework for a security-purpose VMM. Our proposal employs a smart card (ID card) for user authentication. The proposed ID management framework can provide generic programming interfaces to existing VMM software. Our ID management framework realizes an authentication between a VMM and its users, an authorization for a VM boot operation, storage of cryptographic keys for VMM-layer's disk encryption/decryption, and access control for virtual/physical resources based on a user identity. In this paper, we show the prototype implementation of our ID management framework and its integration into the proven VMM software, QEMU.
At Last, 18F-FDG for Inflammation and Infection! (2021)

Several decades after 18F-FDG was first used as a radiotracer, the time has now come for the United States to embrace 18F-FDG as the molecular imaging test of choice for many inflammatory and infectious indications (including sarcoidosis, fever of unknown origin, and musculoskeletal infection) as
Least‐squares characteristics and finite elements for advection–dispersion simulation (1990)

Abstract The method of characteristics is combined with the method of least‐squares to solve the advection equation within the finite element framework. Fourier mode analysis shows that the numerical scheme is stable and accurate even when a linear basis function is used. However, in practical application, the involvement of using numerical quadrature in this method can produce numerical instability, depending on the value of the Courant number used. It is found that using C 1 continuous Hermitian cubic basis functions in the scheme reduces the degree of instability significantly and produces high accuracy. When being used in a split‐operator approach, this method combines naturally with the standard finite element method and results in a highly accurate scheme for advection–dispersion simulation.
The antifungal mechanism of action of zinc pyrithione (2011)

The molecular basis for the antifungal activity of the commonly used active ZPT has been elucidated, more than 50 years since its introduction, as utilizing a copper toxicity mechanism that targets critical iron-sulphur proteins.
Low-Temperature Synthesis of Zintl Compounds with a Single-Source Molecular Precursor (1998)

Thermolysis of the heterobimetallic phosphinidene complex [Sb(PCy)3]2- Li6.6HNMe2 (Cy = C6H11) at 303 to 313 kelvin gives Zintl compounds containing (Sb7)3- anions. The complex thus constitutes a stable molecular single-source precursor to Zintl compounds and provides a potential low-temperature route to photoactive alkali metal antimonates. The new chemical reaction involved, which is driven thermodynamically by the formation of P-P bonds, has implications in the low-temperature synthesis of other technologically important materials (such as gallium arsenide).
Text mining in livestock animal science: Introducing the potential of text mining to animal sciences 1 (2012)

In biological research, establishing the prior art by searching and collecting information already present in the domain has equal importance as the experiments done. To obtain a complete overview about the relevant knowledge, researchers mainly rely on 2 major information sources: i) various biological databases and ii) scientific publications in the field. The major difference between the 2 information sources is that information from databases is available, typically well structured and condensed. The information content in scientific literature is vastly unstructured; that is, dispersed among the many different sections of scientific text. The traditional method of information extraction from scientific literature occurs by generating a list of relevant publications in the field of interest and manually scanning these texts for relevant information, which is very time consuming. It is more than likely that in using this "classical" approach the researcher misses some relevant information mentioned in the literature or has to go through biological databases to extract further information. Text mining and named entity recognition methods have already been used in human genomics and related fields as a solution to this problem. These methods can process and extract information from large volumes of scientific text. Text mining is defined as the automatic extraction of previously unknown and potentially useful information from text. Named entity recognition (NER) is defined as the method of identifying named entities (names of real world objects; for example, gene/protein names, drugs, enzymes) in text. In animal sciences, text mining and related methods have been briefly used in murine genomics and associated fields, leaving behind other fields of animal sciences, such as livestock genomics. The aim of this work was to develop an information retrieval platform in the livestock domain focusing on livestock publications and the recognition of relevant data from cattle and pigs. For this purpose, the rather noncomprehensive resources of pig and cattle gene and protein terminologies were enriched with orthologue synonyms, integrated in the NER platform, ProMiner, which is successfully used in human genomics domain. Based on the performance tests done, the present system achieved a fair performance with precision 0.64, recall 0.74, and F(1) measure of 0.69 in a test scenario based on cattle literature.
Multiple roles for endothelin in melanocyte development: regulation of progenitor number and stimulation of differentiation (1996)

Melanocytes in the skin are derived from the embryonic neural crest. Recently, mutations in endothelin 3 and the endothelin receptor B genes have been shown to result in gross pigment defects, indicating that this signalling pathway is required for melanocyte development. We have examined the effects of endothelins on melanocyte progenitors in cultures of mouse neural crest. Firstly, they stimulate an increase in progenitor number and act synergistically with another factor, Steel factor, in the survival and proliferation of the progenitors. These findings are consistent with findings from mice with natural mutations in the endothelin receptor B gene, which show an early loss of melanocyte progenitors. Secondly, endothelins induce differentiation of the progenitors into fully mature pigmented melanocytes. This finding is consistent with the expression of endothelins in the skin of mice at the initiation of pigmentation. The melanocytes generated in endothelin-treated cultures also become responsive to alpha melanocyte-stimulating hormone, which then acts to regulate the activity of the pigmentation pathway. These findings indicate two key roles for endothelin in melanocyte development: regulation of expansion of the progenitor pool and differentiation of progenitors into mature melanocytes.
The Recent Development of Rare Earth-Doped Borate Laser Crystals (2012)

Laser 64 stability and is moisture free. The Ca 2+ ion in CBO is surrounded by eight nearest oxygen to form a distorted polyhedron, in which the only symmetry is a two-fold axis passing through the Ca ion. Thereby the calcium ions belong to the C 2 point symmetry. As in this borate the trivalent rare earth ion is introduced on the divalent cation site, a mechanism for charge compensation should be considered.
Modified Current Regulator for High-Power Traction Motor with Low Sampling Frequency to Operating Frequency Ratio (2019)

Time delay caused by digital control may significantly degrade the controllability of electric vehicle traction motor controller in high-speed applications. This paper proposes a method to reduce the side impact of digital delay on the motor current control. The complex vector current regulator considering delay and hold is modelled in d-q frame. Double-sided frequency response function is applied to analyze the stability, dynamic response and decoupling. State feedback control with phase compensation is used to enhance the stability, bandwidth and decoupling effect. The feasibility and effectiveness of this method is verified by simulation results.
THE EFFECT OF TUMOUR NECROSIS FACTOR-α ON MATURITY OF NIH3T3 CELLS (2010)

Objective To study the effect of tumour necrosis factor-α(TNF-α) on the maturity of NIH3T3 cells. Methods NIH3T3 cells were cultured in vitro,and divided into three groups:group A(control group),group B(group TNF-α) and group C(group TNF-α+Anti-TNFRSF1B).After the cell suspension of 2×108/L had been made,it was then put into 25 cm2 culture flask.When the cells were confluented,they were cultured in serum-free DMEM high-glucose medium for 12-16 hours.The group A was then changed to be cultured in DMEM high-glucose medium with 2% serum;the group B was changed to be cultured in 100 μg/L TNF-α medium;and the group C was cultured in medium with 50 μg/L Anti-TNFRSF1B for one hour and then cultured in medium with 100 μg/L TNF-α.RT-PCR and Western Blot method were applied to detect the expressions of typeⅠcollagen and matrix metalloproteinase 3(MMP3) mRNA and protein in each group. Results The expressions of MMP3 mRNA and protein in groups B and C were significantly different from that in group A(t=-13.413-5.076,P0.05),the difference between groups B and C was also significant(t=4.441-5.076,P0.01).The expressions of both mRNA and protein of type Ⅰ collagen in groups B and C showed difference as compared with the group A(t=-4.950-5.808,P0.05),the statistic difference between groups B and C was also significant(t=-4.950——3.823,P0.05). Conclusion TNF-α can promote the activation of NIH3T3 cells.
A simple parallel-plate wave launcher in substrate integrated waveguide technology (2015)

We present a compact substrate integrated waveguide (SIW) fed, parallel-plate wave launcher which is able to excite a TEM wave in a dielectric-filled parallel-plate waveguide (PPW). The engineered wave-front with controlled amplitude and phase distribution, can generate a desired aperture for conventional antenna structures and other integrated feed systems. For example, our proposed PPW launcher may be useful when feeding planar, parallel-plate slot-array antennas in PCB technology. In this work theoretical design curves are initially presented for such PPW launchers. Results are then confirmed by full-wave simulations of two SIW-fed, PPW designs operating at 15 GHz, and covering two different aperture widths of 5 cm and 10 cm. Our novel approach for simple, PPW launching at microwave and millimeter-wave frequencies can also be applied to other parallel-plate based guides, low-cost transitions, and compact dividing/combing circuits for new antenna feed systems.
ChemInform Abstract: 4,5‐Bis(diarylmethylene)‐1,3‐dithiole: A Novel Helical Electron Donor Exhibiting Electrochromic Behavior. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
[The distribution and activities of hemodynamic laboratories in Italy: the implications for the quality of services]. (1994)

Even if data could be underestimated, a great difference in geographical distribution of labs was confirmed. This might be explained by morbidity, population age and mobility of patients across the country. The percentage of labs performing fewer than 300 studies is relevant, in particular in the south and in the Isles. Planning for future requirements should include the amelioration of utilization rates (in a perspective of cost containment and patient safety), a thorough evaluation of demographic and morbidity trends, and an estimate of the proportion of inappropriate procedures.
Malignant peritoneal mesothelioma in a pediatric patient presenting as traumatic hemoperitoneum (2006)

Primary diffuse malignant peritoneal mesothelioma (MPM) is a rare malignancy, especially in pediatric patients. We describe a 15-year-old girl with diffuse MPM presenting with bloody ascites, anemia, and abdominal pain, who had a history of blunt abdominal injury about 3 days before admission. Emergent computed tomographic (CT) scans revealed massive ascites with multiple high-density mass-like lesions occupying the mesentery and omentum. The initial clinical presentation was misdiagnosed as traumatic hemoperitoneum. The patient underwent exploratory laparotomy and histologic diagnosis was established by immunohistochemistry.
Efficient Boson Sampling Schemes using Dispersion and Pulse Shaping (2015)

We present Boson Sampling schemes in the time-frequency basis that allow for more modes, fewer sources and detectors and are more tolerant to temporal mismatch than Boson Sampling schemes using photons in many spatial modes.
Experimental test results for a parallel transmission lines protection scheme using wavelet transform (2004)

A scheme for the protection of parallel transmission lines using wavelet transform (WT) has been implemented and results of experimental tests on a physical power system model are described. The relaying scheme depends on the three line voltages and the six line currents of the two parallel lines at each end. Fault detection, fault discrimination and calculation of the phasors of the measured signals are done using WT. The performance of the proposed scheme has been investigated by a number of online tests. The results show that all types of shortcircuit faults can be correctly identified in less than one cycle of the fundamental frequency.
A pipeline for malignancy and therapy agnostic assessment of cancer drug response using cell mass measurements (2022)

Functional precision medicine offers a promising complement to genomics-based cancer therapy guidance by testing drug efficacy directly on a patient's tumor cells. Here, we describe a workflow that utilizes single-cell mass measurements with inline brightfield imaging and machine-learning based image classification to broaden the clinical utility of such functional testing for cancer. Using these image-curated mass measurements, we characterize mass response signals for 60 different drugs with various mechanisms of action across twelve different cell types, demonstrating an improved ability to detect response for several slow acting drugs as compared with standard cell viability assays. Furthermore, we use this workflow to assess drug responses for various primary tumor specimen formats including blood, bone marrow, fine needle aspirates (FNA), and malignant fluids, all with reports generated within two days and with results consistent with patient clinical responses. The combination of high-resolution measurement, broad drug and malignancy applicability, and rapid return of results offered by this workflow suggests that it is well-suited to performing clinically relevant functional assessment of cancer drug response.