gebhart/patrepeval huggingface dataset:
Practical Skew Handling in Parallel Joins (1992)

We present an approach to dealing with skew in parallel joins in database systems. Our approach is easily implementable within current parallel DBMS, and performs well on skewed data without degrading the performance of the system on non-skewed data. The main idea is to use multiple algorithms, each specialized for a different degree of skew, and to use a small sample of the relations being joined to determine which algorithm is appropriate. We developed, implemented, and experimented with four new skew-handling parallel join algorithms; one, which we call virtual processor range partitioning, was the clear winner in high skew cases, while traditional hybrid hash join was the clear winner in lower skew or no skew cases. We present experimental results from an implementation of all four algorithms on the Gamma parallel database machine. To our knowledge, these are the first reported skew-handling numbers from an actual implementation. 1 Introduction Multiprocessor database system techn...
Supplementary Figure A6-2 from High Expression of Lymphocyte-Associated Genes in Node-Negative HER2+ Breast Cancers Correlates with Lower Recurrence Rates (2023)

Supplementary Figure A6-2 from High Expression of Lymphocyte-Associated Genes in Node-Negative HER2+ Breast Cancers Correlates with Lower Recurrence Rates
The decipher speech recognition system (2002)

A large-vocabulary, continuous-speech system, called DECIPHER, which is based on a hidden Markov model (HMM) approach and is designed to achieve high word accuracy in a speaker-independent mode is described. The results of a series of experiments that test acoustic and phonological adaptation of the DECIPHER system to the pronunciations of a single speaker in a speaker-dependent task are presented. Estimating the probabilities of alternative pronunciations and speaker-dependent phonology are discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Noncanonical protein kinase A activation by oligomerization of regulatory subunits as revealed by inherited Carney complex mutations (2021)

Familial mutations of the protein kinase A (PKA) R1α regulatory subunit lead to a generalized predisposition for a wide range of tumors, from pituitary adenomas to pancreatic and liver cancers, commonly referred to as Carney complex (CNC). CNC mutations are known to cause overactivation of PKA, but the molecular mechanisms underlying such kinase overactivity are not fully understood in the context of the canonical cAMP-dependent activation of PKA. Here, we show that oligomerization-induced sequestration of R1α from the catalytic subunit of PKA (C) is a viable mechanism of PKA activation that can explain the CNC phenotype. Our investigations focus on comparative analyses at the level of structure, unfolding, aggregation, and kinase inhibition profiles of wild-type (wt) PKA R1α, the A211D and G287W CNC mutants, as well as the cognate acrodysostosis type 1 (ACRDYS1) mutations A211T and G287E. The latter exhibit a phenotype opposite to CNC with suboptimal PKA activation compared with wt. Overall, our results show that CNC mutations not only perturb the classical cAMP-dependent allosteric activation pathway of PKA, but also amplify significantly more than the cognate ACRDYS1 mutations nonclassical and previously unappreciated activation pathways, such as oligomerization-induced losses of the PKA R1α inhibitory function.
Randomized controlled trial of 7, 28, vs 42 day stored red blood cell transfusion on oxygen delivery (VO2 max) and exercise duration (2020)

These data indicate that 42-day, 28-day, and 7-day RBCs have similar ability to deliver oxygen.
Analyzing Human Negotiation using Automated Cognitive Behavior Analysis: The Effect of Personality (2018)

In this paper we study the influence of personality traits in negotiation by using a methodology for automated cognitive behavior analysis (ACBA). This methodology uses genetic programming (GP) for hypothesis generation and testing of human behavior with the goal of explaining the underlying mental structures guiding people’s actions during a task. ACBA iteratively generates programs - the hypotheses - capable of explaining the behavior exhibited by an individual during a multi-level, multi-issue, sequential bargaining task against an artificial agent. Our study focuses on the influence of the personality traits of social-value orientation (SVO) and Machiavellianism (Mach). The results show that by using ACBA, we are able to identify differences in the outcomes of programs emerging from GP that are consistent with the influences that different SVO and Mach profiles have in human negotiation behavior.
Somatic hypermutation of the AID transgene in B and non-B cells (2002)

Somatic hypermutation (SHM) of the Ig genes is required for affinity maturation of the humoral response to foreign antigens. Activation-induced cytidine deaminase (AID), which is specifically expressed in germinal center centroblasts, is indispensable for this process. Expression of AID is sufficient to activate SHM in hybridomas, non-B cells, and Escherichia coli, suggesting that it initiates the mutational process by deaminating DNA. However, the cis-acting sequences that are responsible for targeting AID activity to the variable (V) region of Ig genes are unknown. Here we show that expression of AID in B cell lines (i.e., Burkitt's lymphoma Ramos and hybridoma P1-5) not only causes hypermutation of Ig sequences, but also of the AID transgene itself. Because it is possible that B cell-specific transacting factors bind to and recruit the "mutator" to the AID transgene, we tested whether the AID transgene can mutate in non-B cells. Indeed, we show that expression of AID in Chinese hamster ovary cells causes SHM of both the Ig and AID transgenes. These data suggest that high transcription rates alone may predispose any gene to mutation by AID but do not preclude that there are specific B cell factors that account for the extremely high rate of V mutation in vivo and its targeting to the V region.
Self-supervised Learning of Pixel-wise Anatomical Embeddings in Radiological Images. (2020)

Radiological images such as computed tomography (CT) and X-rays render anatomy with intrinsic structures. Being able to reliably locate the same anatomical or semantic structure across varying images is a fundamental task in medical image analysis. In principle it is possible to use landmark detection or semantic segmentation for this task, but to work well these require large numbers of labeled data for each anatomical structure and sub-structure of interest. A more universal approach would discover the intrinsic structure from unlabeled images. We introduce such an approach, called Self-supervised Anatomical eMbedding (SAM). SAM generates semantic embeddings for each image pixel that describes its anatomical location or body part. To produce such embeddings, we propose a pixel-level contrastive learning framework. A coarse-to-fine strategy ensures both global and local anatomical information are encoded. Negative sample selection strategies are designed to enhance the discriminability among different body parts. Using SAM, one can label any point of interest on a template image, and then locate the same body part in other images by simple nearest neighbor searching. We demonstrate the effectiveness of SAM in multiple tasks with 2D and 3D image modalities. On a chest CT dataset with 19 landmarks, SAM outperforms widely-used registration algorithms while being 200 times faster. On two X-ray datasets, SAM, with only one labeled template image, outperforms supervised methods trained on 50 labeled images. We also apply SAM on whole-body follow-up lesion matching in CT and obtain an accuracy of 91%.
Heterogeneous expression of melanoma antigen (hMAGE) mRNA in mesenchymal neoplasia (2006)

Recommendations have been advanced recently for the use of cancer/testis (CT) immunotherapy against sarcomas. CT antigens are encoded by cancer-germline genes (e.g., hMAGE family) that are expressed in tumors and male germline cells but typically not in normal tissues. At present, little information is available regarding CT expression in mesenchymal neoplasms, and it remains uncertain whether CT immunotherapy will serve as a viable alternative or adjunct to current sarcoma therapies involving resection, followed by adjuvant radiotherapy and/or chemotherapy. In this study, hMAGEA2, hMAGEA3, hMAGEA4, and hMAGEC1 mRNA content in 21 benign mesenchymal tumors (representing seven histotypes) and 28 primary sarcomas (10 histotypes) was inventoried using real-time-PCR and then compared against hMAGE mRNA expression in non-sarcomatous malignancies, three cell lines, and muscle. hMAGEA2, hMAGEA3, and hMAGEC1 transcripts were infrequent in mesenchymal tissues in general, whereas hMAGEA4 mRNA was present in 84% of all mesenchymal tumors, 100% of non-sarcomatous tumors, all three cell lines, and in four of five muscle samples. Although hMAGEA4 mRNA was detected in four of five muscle preparations, there was no indication that the mRNA was translated into protein. The presence of hMAGEA4 mRNA in muscle, plus the inconsistent and infrequent occurrence of hMAGEA2, hMAGEA3, and hMAGEC1 mRNA within and among mesenchymal tumor histotypes, makes these four hMAGE antigens unlikely candidates for sarcoma-specific immunotherapy.
PROPYLENE GLYCOL AND GLYCEROL AS A FEED ADDITIVE FOR LACTATING DAIRY COWS: AN EVALUATION OF BLOOD METABOLITE PARAMETERS (1973)

An extensive trial for testing the antiketogenic potency of glycerol and propylene glycol (DL-1,2 propanediol) was conducted with milking Holsteins and Ayrshires over a 2-yr period. Through weekly blood analyses of free fatty acids, glucose, β-hydroxybutyrate, and acetoacetate for an 8-wk period post-partum, it was possible to classify these cows as normal, clinically ketotic, and subclinically ketotic. The results showed that in cows that were not stressed by either high lactation yield or low concentrate intake these chemical additives only slightly depressed blood ketones and free fatty acids below control values. The beneficial properties of these additives became obvious in cows stressed by adverse environmental factors and slightly reduced levels of concentrate intake. In these cows, the addition of propylene glycol to the concentrate ration significantly reduced blood ketones and plasma free fatty acids and increased the concentration of blood glucose. It was concluded that the use of propylene glycol as a feed additive (3 and 6% of the concentrate) should be economically attractive in high-producing dairy herds because it will significantly decrease the incidence of clinical and subclinical ketosis in cows during the immediate postpartum period (4–8 wk) when they are most susceptible to the metabolic disorder.
Neural Correlates of Response Inhibition in Pediatric Bipolar Disorder (2010)

During accurate NoGo but impaired Go trial performance, children with BD showed increased right DLPFC activation versus controls, suggesting increased recruitment of executive control regions for accurate response inhibition. Studies relating these results to mood regulation in pediatric BD are warranted.
Design and synthesis of P2-P1'-linked macrocyclic human renin inhibitors (1991)

Using a computer model of the active site of human renin developed at Merck, we designed a series of novel P2-P1'-linked, macrocyclic renin inhibitors 3-10. These unique inhibitors incorporate a transition-state isostere within a 13- or 14-membered ring. The three most active compounds in this family were 13-membered-ring glutamine-derived inhibitor 3, 14-membered-ring diaminopropionic acid derived inhibitor 6, and 13-membered-ring diol 9 (IC50 0.61, 0.59, 0.65 microM, respectively). Modification of inhibitor 3 at P4 led to 56 nM macrocyclic renin inhibitor 39. This study shows the viability of renin inhibitor designs which incorporate a scissile-bond replacement within a macrocycle.
Discrete Structures (KSU) (2018)

This Grants Collection for Discrete Structures was created under a Round Eleven ALG Textbook Transformation Grant. Affordable Learning Georgia Grants Collections are intended to provide faculty with the frameworks to quickly implement or revise the same materials as a Textbook Transformation Grants team, along with the aims and lessons learned from project teams during the implementation process. Documents are in .pdf format, with a separate .docx (Word) version available for download. Each collection contains the following materials: Linked Syllabus Initial Proposal Final Report
Gain-of-function Mutations in Transient Receptor Potential C6 (TRPC6) Activate Extracellular Signal-regulated Kinases 1/2 (ERK1/2) (2013)

Gain-of-function mutations in the canonical transient receptor potential 6 (TRPC6) gene are a cause of autosomal dominant focal segmental glomerulosclerosis (FSGS). The mechanisms whereby abnormal TRPC6 activity results in proteinuria remain unknown. The ERK1/2 MAPKs are activated in glomeruli and podocytes in several proteinuric disease models. We therefore examined whether FSGS-associated mutations in TRPC6 result in activation of these kinases. In 293T cells and cultured podocytes, overexpression of gain-of-function TRPC6 mutants resulted in increased ERK1/2 phosphorylation, an effect dependent upon channel function. Pharmacologic inhibitor studies implicated several signaling mediators, including calmodulin and calcineurin, supporting the importance of TRPC6-mediated calcium influx in this process. Through medium transfer experiments, we uncovered two distinct mechanisms for ERK activation by mutant TRPC6, a cell-autonomous, EGF receptor-independent mechanism and a non-cell-autonomous mechanism involving metalloprotease-mediated release of a presumed EGF receptor ligand. The inhibitors KN-92 and H89 were able to block both pathways in mutant TRPC6 expressing cells as well as the prolonged elevation of intracellular calcium levels upon carbachol stimulation seen in these cells. However, these effects appear to be independent of their effects on calcium/calmodulin-dependent protein kinase II and PKA, respectively. Phosphorylation of Thr-70, Ser-282, and Tyr-31/285 were not necessary for ERK activation by mutant TRPC6, although a phosphomimetic TRPC6 S282E mutant was capable of ERK activation. Taken together, these results identify two pathways downstream of mutant TRPC6 leading to ERK activation that may play a role in the development of FSGS.
L'affaire Clearstream (2002)

Résumé Peut-on traiter de l'avenir de la protection sociale en trois articles ? Evidemment non. Pour nourrir cependant le plus largement possible la discussion, nous avons fait le choix de trois angles d'approche. Partir de notre propre système : quels sont les avenirs possibles de la protection sociale en France ? Elargir à l'Europe : quelles sont les dynamiques à l'oeuvre dans les pays de l'Union européenne ? Enfin poser la question de la redistribution : quels effets les différents systèmes ont-ils sur la réduction des inégalités ?
Future therapies for the prevention and treatment of venous and arterial thrombosis (1998)

The incidence of thrombosis as a complication of invasive surgery, in cancer patients, as a cause or complication of stroke, acute myocardial infarction (AMI), thrombolysis, unstable angina (UA) or angioplasty is substantial. To better serve this patient population in the prevention and prophylaxis of thrombosis, new types of anticoagulant drugs are under development by the pharmaceutical industry. The goal of these efforts are orally-active anticoagulants with specificity and pharmacokinetic properties that could translate into better control of anticoagulation and thrombosis and less bleading liability compared to the currently used anticoagulants: heparin, the low molecular weight heparins and warfarin. Various approaches for which there is a great deal of activity include: tissue factor/Factor VIIa inhibitors, Factor Xa inhibitors, thrombin inhibitors, glycoprotein IIb/IIIa antagonists. There is also interest in Factor IXa inhibitors, thrombin receptor antagonists and inhibitors of plasminogen activator inhibitor-1.
Hydrogen evolution from organic “hydrides” (2005)

Benzimidazolines (dihydrobenzimidazoles) are shown for the first time to eliminate hydrogen (H2) by catalyzed reaction with protic compounds.
Using dual eye tracking to uncover personal gaze patterns during social interaction (2018)

We report the personal eye gaze patterns of people engaged in face-to-face getting acquainted conversation. Considerable differences between individuals are underscored by a stability of eye gaze patterns within individuals. Results suggest the existence of an eye-mouth gaze continuum. This continuum includes some people showing a strong preference for eye gaze, some with a strong preference for mouth gaze, and others distributing their gaze between the eyes and mouth to varying extents. Additionally, we found evidence of within-participant consistency not just for location preference but also for the duration of fixations upon the eye and mouth regions. We also estimate that during a 4-minute getting acquainted conversation mutual face gaze constitutes about 60% of conversation that occurs via typically brief instances of 2.2 seconds. Mutual eye contact ranged from 0-45% of conversation, via very brief instances. This was despite participants subjectively perceiving eye contact occurring for about 70% of conversation. We argue that the subjective perception of eye contact is a product of mutual face gaze instead of actual mutual eye contact. We also outline the fast activity of gaze movements upon various locations both on and off face during a typical face-to-face conversation.
Scalable, graph-based network vulnerability analysis (2002)

Even well administered networks are vulnerable to attack. Recent work in network security has focused on the fact that combinations of exploits are the typical means by which an attacker breaks into a network. Researchers have proposed a variety of graph-based algorithms to generate attack trees (or graphs). Either structure represents all possible sequences of exploits, where any given exploit can take advantage of the penetration achieved by prior exploits in its chain, and the final exploit in the chain achieves the attacker's goal. The most recent approach in this line of work uses a modified version of the model checker NuSMV as a powerful inference engine for chaining together network exploits, compactly representing attack graphs, and identifying minimal sets of exploits. However, it is also well known that model checkers suffer from scalability problems, and there is good reason to doubt whether a model checker can handle directly a realistic set of exploits for even a modest-sized network. In this paper, we revisit the idea of attack graphs themselves, and argue that they represent more information explicitly than is necessary for the analyst. Instead, we propose a more compact and scalable representation. Although we show that it is possible to produce attack trees from our representation, we argue that more useful information can be produced, for larger networks, while bypassing the attack tree step. Our approach relies on an explicit assumption of monotonicity, which, in essence, states that the precondition of a given exploit is never invalidated by the successful application of another exploit. In other words, the attacker never needs to backtrack. The assumption reduces the complexity of the analysis problem from exponential to polynomial, thereby bringing even very large networks within reach of analysis
Redox-Switchable Chalcogen Bonding for Anion Recognition and Sensing (2022)

Inspired by the success of its related sigma-hole congener halogen bonding (XB), chalcogen bonding (ChB) is emerging as a powerful noncovalent interaction with a plethora of applications in supramolecular chemistry and beyond. Despite its increasing importance, the judicious modulation of ChB donor strength remains a formidable challenge. Herein, we present, for the first time, the reversible and large-scale modulation of ChB potency by electrochemical redox control. This is exemplified by both the switching-ON of anion recognition via ChB oxidative activation of a novel bis(ferrocenyltellurotriazole) anion host and switching-OFF reductive ChB deactivation of anion binding potency with a telluroviologen receptor. The direct linking of the redox-active center and ChB receptor donor sites enables strong coupling, which is reflected by up to a remarkable 3 orders of magnitude modulation of anion binding strength. This is demonstrated through large voltammetric perturbations of the respective receptor ferrocene and viologen redox couples, enabling, for the first time, ChB-mediated electrochemical anion sensing. The sensors not only display significant anion-binding-induced electrochemical responses in competitive aqueous-organic solvent systems but can compete with, or even outperform similar, highly potent XB and HB sensors. These observations serve to highlight a unique (redox) tunability of ChB and pave the way for further exploration of the reversible (redox) modulation of ChB in a wide range of applications, including anion sensors as well as molecular switches and machines.
[Experience using sinakten-retard in the treatment of muscular sclerosis]. (1978)

The experience of the authors demonstrated that the best results in sinakten-retard treatment were attained in patients with mild and moderate degrees of severity of the disease. However, even in patients with a protracted development, treatment by sinakten-retard increased the muscular strength in the paralyzed extremities, diminished the increased muscular tone and increased the volume of movements. All these facts permit the authors to recommend sinakten-retard for the treatment of disseminated sclerosis.
Equivalence Between Higher-Order Stress Power and Heat Flux in Energy Equation Based on Lattice Dynamics (1999)

The essence of macroscopic quantities in solid mechanics can be grasped by expressing these quantities in terms of kinematic and mechanical quantities of atoms. In this paper, a method is proposed for obtaining the microscopic definitions of internal forces of continua such as stress, higher-order stresses and heat flux. Moreover, the relation between higher-order stress power and heat flux is discussed expressing the first law of thermodynamics with microscopic quantities in the mesodomain. Comparing heat flux with higher-order stress power, it is clarified that the divergence of heat flux is equivalent to the total of each order power due to higher-order stresses.
Středověký úpravnický a hornický areál Cvilínek u Černova naPelhřimovsku (2012)

In this paper are presented the mining and settlement areals, which are regarded for the remains of the mediaeval silver producing workshops, where the silver was the basic mint metall and one of important grounds of dynamic development of the přemyslidic dominium in 13th century. On the site about 1,28 ha has been detected the remains of the raw ore selection, containing the polymetallic sulphidic ores, which was exploited by the near ore deposit. Extraordinary well preserved was the ore washing workshop with the remains of the wooden constructions. The other areal was the metallurgic workshop with the remains of the smelting ovens. Completely different objects were excavated on the immediatelly situated mining settlement area, where was also small, with the ditch enclosured place.