gebhart/patrepeval huggingface dataset:
Correlation of qEEG with PET in Schizophrenia (1998)

PET relative metabolism was correlated with quantitative EEG in 9 schizophrenic patients. The PET metabolic regions of interest were the frontal lobes, thalamus and basal ganglia, and right and left temporal lobes. Significant positive correlations were seen for the frontal lobes and delta EEG power, and alpha power with subcortical metabolism. The physiologic plausibility of those correlations is discussed with reference to the possible effect of neuroleptic medication.
Viperin Restricts Zika Virus and Tick-Borne Encephalitis Virus Replication by Targeting NS3 for Proteasomal Degradation (2018)

Flaviviruses are arthropod-borne viruses that constitute a major global health problem, with millions of human infections annually. Their pathogenesis ranges from mild illness to severe manifestations such as hemorrhagic fever and fatal encephalitis. Type I interferons (IFNs) are induced in response to viral infection and stimulate the expression of interferon-stimulated genes (ISGs), including that encoding viperin (virus-inhibitory protein, endoplasmic reticulum associated, IFN inducible), which shows antiviral activity against a broad spectrum of viruses, including several flaviviruses. Here we describe a novel antiviral mechanism employed by viperin against two prominent flaviviruses, tick-borne encephalitis virus (TBEV) and Zika virus (ZIKV). Viperin was found to interact and colocalize with the structural proteins premembrane (prM) and envelope (E) of TBEV, as well as with nonstructural (NS) proteins NS2A, NS2B, and NS3. Interestingly, viperin expression reduced the NS3 protein level, and the stability of the other interacting viral proteins, but only in the presence of NS3. We also found that although viperin interacted with NS3 of mosquito-borne flaviviruses (ZIKV, Japanese encephalitis virus, and yellow fever virus), only ZIKV was sensitive to the antiviral effect of viperin. This sensitivity correlated with viperin's ability to induce proteasome-dependent degradation of NS3. ZIKV and TBEV replication was rescued completely when NS3 was overexpressed, suggesting that the viral NS3 is the specific target of viperin. In summary, we present here a novel antiviral mechanism of viperin that is selective for specific viruses in the genus <i>Flavivirus</i>, affording the possible availability of new drug targets that can be used for therapeutic intervention.<b>IMPORTANCE</b> Flaviviruses are a group of enveloped RNA viruses that cause severe diseases in humans and animals worldwide, but no antiviral treatment is yet available. Viperin, a host protein produced in response to infection, effectively restricts the replication of several flaviviruses, but the exact molecular mechanisms have not been elucidated. Here we have identified a novel mechanism employed by viperin to inhibit the replication of two flaviviruses: tick-borne encephalitis virus (TBEV) and Zika virus (ZIKV). Viperin induced selective degradation via the proteasome of TBEV and ZIKV nonstructural 3 (NS3) protein, which is involved in several steps of the viral life cycle. Furthermore, viperin also reduced the stability of several other viral proteins in a NS3-dependent manner, suggesting a central role of NS3 in viperin's antiflavivirus activity. Taking the results together, our work shows important similarities and differences among the members of the genus <i>Flavivirus</i> and could lead to the possibility of therapeutic intervention.
Efficient synthetic methodology for 1,3-dithiolane 1 -oxides via singlet oxidation of 1,3-dithiolanest (1990)

Singlet oxidation of 1,3-dithiolanes furnishes synthetically useful yields of 1,3-dithiolane 1-oxides. However, 2-ethyl-2-phenyl-1,3-dithiolane13 gave 2-ethyl-4-hydroxy-2-phenyl-1,3-dithiolane 19 as a major product.
New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c (2002)

The regulation of hepatic glucose metabolism has a key role in whole-body energy metabolism, since the liver is able to store (glycogen synthesis, lipogenesis) and to produce (glycogenolysis, gluconeogenesis) glucose. These pathways are regulated at several levels, including a transcriptional level, since many of the metabolism-related genes are expressed according to the quantity and quality of nutrients. Recent advances have been made in the understanding of the regulation of hepatic glycolytic, lipogenic and gluconeogenic gene expression by pancreatic hormones, insulin and glucagon and glucose. Here we review the role of the transcription factors forkhead and sterol regulatory element binding protein-1c in the inductive and repressive effects of insulin on hepatic gene expression, and the pathway that leads from glucose to gene regulation with the recently discovered carbohydrate response element binding protein. We discuss how these transcription factors are integrated in a regulatory network that allows a fine tuning of hepatic glucose storage or production, and their potential importance in metabolic diseases.
Jun Axup (2012)

RETURN TO ISSUEPREVACS NewsNEXTJun AxupCite this: Chem. Eng. News 2012, 90, 34, 40Publication Date (Print):August 20, 2012Publication History Published online29 March 2013Published inissue 20 August 2012https://pubs.acs.org/doi/10.1021/cen-09034-cover2https://doi.org/10.1021/cen-09034-cover2acs-newsACS PublicationsCopyright © 2012 Chemical & Engineering News. This publication is available under these Terms of Use. This publication is free to access through this site. Learn MoreArticle Views80Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (268 KB) SUBJECTS:Genetics,Materials,Molecules,Students Get e-Alerts
Joint Training of a Convolutional Network and a Graphical Model for Human Pose Estimation (2014)

This paper proposes a new hybrid architecture that consists of a deep Convolutional Network and a Markov Random Field. We show how this architecture is successfully applied to the challenging problem of articulated human pose estimation in monocular images. The architecture can exploit structural domain constraints such as geometric relationships between body joint locations. We show that joint training of these two model paradigms improves performance and allows us to significantly outperform existing state-of-the-art techniques.
Multi-Layer Greenfield Re-Grooming with Wavelength Defragmentation (2012)

Flexible network design for multi-granular and quasi-dynamic traffic is important to minimize resource requirements. In the wavelength layer, wavelength blocking must also be reduced to achieve further cost reduction. We propose a novel traffic accommodation scheme based on repetitive Greenfield Re-grooming with Wavelength Defragmentation (GRWD), which is similar to storage-disk defragmentation. Numerical evaluation shows the required minimum number of sets of transport equipment for the proposed scheme.
The Experimental Transmission of Anaplasmosis by Debmacentor andersoni (1933)

It has been determined that anaplasmosis may be transmitted by Dernmcentor andersoni under the following conditions: (1) Larvae may acquire the infection by engorging on a bovine whose blood contains anaplasms and may transmit the infection as nymphs to susceptible bovines; and (2) in a similar manner the nymphs may acquire the infection and transmit it as adults. The test of “hereditary” transmission was negative, i.e. the larvae did not apparently acquire the infection from adult females which engorged on carriers of anaplasmosis. Conditions of transmission by D. andersoni are the same as those which have thus far been determined by me for D. variabilis . The incrimination of these two species of tick points to the possibility that anaplasmosis occurring anywhere within the known range of distribution of that disease in the United States may be tick-borne so far as a coincident distribution of known tick carriers can establish this possibility.
Optical and laser properties of the new laser crystals RE3+:Ca2Al2SiO7 (RE = Nd, Ho, Tm, Er) (1994)

In recent years, considerable interest has been devoted to the laser emitting in the 1.5–2 μm range. Ho 3+ and Tm 3+ operate around 2 μm while Er 3+ covers the 1.5 μm range. The development of high power laser diodes lasing around 0.78 and 0.98 μm allows the pumping of these ions. Engaged in the search for new laser materials, we are interested by the gehlenite Ca 2 Al 2 SiO 7 (CAS) matrix. In this matrix, there is an inhomogeneous broadening of the optical lines because of a structural disorder arising from the statistical distribution of Si 4+ and half of the Al 3+ ions on the same kind of tetrahedral sites. This host presents also high phonon frequency leading to short lifetime values when the energy gap difference between the emitting level and the one just below is small. Therefore, for the ions studied only the 4 F 3/2 level for Nd 3+ (τ = 280 μs), 4 I 13/2 for Er 3+ ; (τ = 7.6 ms) and 5 I 7 level for Ho 3+ (τ = 7.4 ms) present lifetime values in the hundred of microseconds to millisecond range. Laser rods of the RE 3+ -doped CAS have been obtained by the Czochralski process.
Ende-zu-Ende Leistungssteuerung heterogener Hochgeschwindigkeitsnetze (2002)

KURZFASSUNG Dieser Artikel befasst sich mit drei voneinander unabhängigen Zugängen zur Steuerung der Leistung eines heterogenen Hochgeschwindigkeitsnetzes für Telekommunikation, welche einander allerdings passend ergänzen. Zunächst wird eine allgemeine Architektur zur Steuerung von Telekommunikationsnetzen definiert. Die Trägertechnologie der Netze kann dabei leitungsvermittelt und paketvermittelt sein, und zwar exklusiv oder im Verein. Aufbauend auf grundsätzlichen Ideen der ITUT und einem allgemeinen Modell zur qualitätsorientierten Steuerung eines Kommunikationsnetzes erfolgt eine Erweiterung der vorhandenden Ansätze für ein gesteuertes Internet. Der zweite Zugang beschäftigt sich mit der Analyse von Synergien zwischen Ansätzen der Leistungsteuerung eines Telekommunikationsnetzes und Ansätzen der Steuerung der Vergebührung dieses Netzes. Dieser Zugang hat zwei unterschiedliche Zielrichtungen: Zunächst wird gezeigt, dass unter Benutzung der Architektur des ersten Ansatzes viele Gemeinsamkeiten zwischen Leistungssteuerung und Finanzsteuerung eines Telekommunikationsnetzes existieren. Danach wird, als eine denkbare Konsequenz der aufgezeigten Synergien die Möglichkeit diskutiert, Modelle für die Bepreisung von Diensten in Telekommunikationsnetzen für die Leistungssteuerung derselben zu benutzen. Der dritte Ansatz entstammt den Verkehrssteuerungskonzepten der IETF und zielt auf die Steuerung von Ende-zu-Ende Pfaden ab. Dabei wird mit mathematischen Methoden die Lastverteilung MPLS-fähiger Netzwerke optimiert. Das dabei benutzte Szenario, nämlich das Berechnen von Verkehrmatrizen auf einer abgesetzten Recheneinheit zur Pfadoptimierung einerseits und das danach notwendige Signalisieren der einzelnen Pfade im Netz andererseits läßt sich gut als eine Anwendung der allgemeinen Architektur aus Ansatz 1 darstellen.
Infinite Dimensional Word Embeddings (2015)

We describe a method for learning word embeddings with stochastic dimensionality. Our Infinite Skip-Gram (iSG) model specifies an energy-based joint distribution over a word vector, a context vector, and their dimensionality. By employing the same techniques used to make the Infinite Restricted Boltzmann Machine (Cote & Larochelle, 2015) tractable, we define vector dimensionality over a countably infinite domain, allowing vectors to grow as needed during training. After training, we find that the distribution over embedding dimensionality for a given word is highly interpretable and leads to an elegant probabilistic mechanism for word sense induction. We show qualitatively and quantitatively that the iSG produces parameter-efficient representations that are robust to language's inherent ambiguity.
Epidermal Growth Factor Receptor Target in Breast Cancer Treatment (2018)

Zhao, Ruya BS; Kaakati, Rayan N. BS; Hollenbeck, Scott T. MD, FACS; Li, Chuan-yuan PhD Author Information
Abstract A113: Chronic stress promotes lymph node metastasis through beta-adrenergic regulation of lymphangiogenesis (2013)

Abstract Lymphangiogenesis drives breast cancer metastasis to lymph nodes. However, the physiological pathways that regulate lymphangiogenesis and lymph node metastasis are yet to be defined. We have previously shown that chronic stress increased metastasis of primary tumour cells to lymph nodes via beta-adrenergic receptor signaling. Consistent with a critical role for beta-adrenergic signaling in cancer progression, recent clinical studies found that blockade of beta-adrenergic activation protected women with triple negative breast cancer from distant metastasis. To investigate if the beta-adrenergic pathway promotes metastasis by impacting lymphangiogenesis, we explored the effect of restraint stress or pharmacological activation of beta-adrenergic pathways in an orthotopic xenograft model of triple negative breast cancer. To physiologically activate beta-adrenergic signaling, mice were subjected to 2 hours of daily restraint for 7 days prior to tumor cell inoculation and 14 days thereafter. Serial bioluminescence imaging revealed chronic stress reduced time to lymph node metastasis and increased tumor cell load in draining lymph nodes. Stress increased the expression of lymphangiogenic factor VEGF-C and its receptor Vefgr-3 and increased lymphangiogenesis within primary tumors. Pharmacological activation of beta-adrenergic signaling with isoproterenol similarly increased lymphangiogenesis and metastasis. Prostaglandin-mediated dilation of lymphatic collector vessels was recently linked to increased breast cancer metastasis. We found stress increased expression of COX-2, the rate limiting enzyme in prostaglandin production, and increased dilation of lymphatic vessels that link primary tumors to draining lymph nodes. Treatment with COX-2 inhibitor celecoxib reversed stress-induced lymph vessel dilation and similarly blocked stress-enhanced lymph node metastasis and tumor lymphangiogenesis. Together, these data show that beta-adrenergic receptor signalling may be an important effector pathway of stress-enhanced lymphangiogenesis and LN metastasis and that beta-blockade of lymphangiogenesis may be an important mechanism in protecting women with breast cancer from the adverse effects of stress biology. Citation Format: Caroline P. Le, Matthew A. Pimentel, Corina Kim, Cameron J. Nowell, Tara Karnezis, Ming G. Chai, Marco Herald, Steven A. Stacker, Erica K. Sloan. Chronic stress promotes lymph node metastasis through beta-adrenergic regulation of lymphangiogenesis. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Breast Cancer Research: Genetics, Biology, and Clinical Applications; Oct 3-6, 2013; San Diego, CA. Philadelphia (PA): AACR; Mol Cancer Res 2013;11(10 Suppl):Abstract nr A113.
Proteogenomic identification of Hepatitis B virus (HBV) genotype-specific HLA-I restricted peptides from HBV-positive patient liver tissues (2022)

The presentation of virus-derived peptides by HLA class I molecules on the surface of an infected cell and the recognition of these HLA-peptide complexes by, and subsequent activation of, CD8<sup>+</sup> cytotoxic T cells provides an important mechanism for immune protection against viruses. Recent advances in proteogenomics have allowed researchers to discover a growing number of unique HLA-restricted viral peptides, resulting in a rapidly expanding repertoire of targets for immunotherapeutics (i.e. bispecific antibodies, engineered T-cell receptors (TCRs), chimeric antigen receptor T-cells (CAR-Ts)) to infected tissues. However, genomic variability between viral strains, such as Hepatitis-B virus (HBV), in combination with differences in patient HLA alleles, make it difficult to develop therapeutics against these targets. To address this challenge, we developed a novel proteogenomics approach for generating patient-specific databases that enable the identification of viral peptides based on the viral transcriptomes sequenced from individual patient liver samples. We also utilized DNA sequencing of patient samples to identify HLA genotypes and assist in target selection. Liver samples from 48 HBV infected patients, primarily from Asia, were examined to reconstruct patient-specific HBV genomes, identify regions within the human chromosomes targeted by HBV integrations and obtain a comprehensive view of HBV peptide epitopes using our HLA class-I (HLA-I) immunopeptidomics discovery platform. Two previously reported HLA associated HBV-derived peptides, HLA-A02 binder FLLTRILTI (S<sub>194-202</sub>) from the large surface antigen and HLA-A11 binder STLPETTVVRR (C<sub>141-151</sub>) from the capsid protein were validated by our discovery platform, but both were detected at very low frequencies. In addition, we identified and validated, using heavy peptide analogues, novel strain-specific HBV-HLA associated peptides, such as GSLPQEHIVQK (P<sub>606-616</sub>) and variants. Overall, our novel approach can guide the development of bispecific antibody, TCR-T, or CAR-T based therapeutics for the treatment of HBV-related HCC and inform vaccine development.
470. Enhanced Transposition Activities of Mutant Sleeping Beauty Transposases (2004)

The development of efficient nonviral vectors that allow for long-term transgene expression may have significant impact on future gene therapy applications. Sleeping Beauty (SB) is a DNA-based transposon system derived from teleost fish sequences that has been shown to have activity within mammalian cells. In this two-part system, the transposase facilitates gene transfer by binding to specific sequences within the transposon (IR/DR elements) and catalyzing its integration into TA dinucleotide sequences within the target genome. The original SB transposase (SB10) was constructed based on consensus sequence alignments using several fish species. In attempt to further improve the transpositional activity of SB10, alignment analysis was conducted using transposase sequences across a wide range of species. Based upon this data, specific mutations were made within the SB10 protein and the functional activity of each mutant was evaluated.
Population genomic screening of all young adults in Australia to detect familial hypercholesterolemia: a cost-effectiveness analysis (2021)

Abstract Background Heterozygous familial hypercholesterolemia (FH) is a highly-penetrant, autosomal dominant monogenic disorder that causes elevated plasma low-density cholesterol (LDL-C) levels and risk of premature coronary heart disease (CHD). To date, the cost-effectiveness of the emerging strategy of genomic screening of adult populations for FH has not been investigated. Purpose To assess the impact and cost-effectiveness of offering population genomic screening to all young adults in Australia to detect heterozygous familial hypercholesterolemia (FH). Methods We designed a decision analysis model to compare the current standard of care for heterozygous FH diagnosis in Australia (opportunistic cholesterol screening and genetic cascade testing) with population genomic screening of adults aged 18–40 years to detect pathogenic variants in the LDLR/APOB/PCSK9 genes. The model captured morbidity/mortality due to coronary heart disease (CHD) over a lifetime horizon, from a healthcare perspective. Risk of CHD, treatment effects, prevalence, and healthcare costs were estimated from published studies. Outcomes included quality adjusted life years (QALYs), costs and incremental cost-effectiveness ratio (ICER), discounted 5% annually. Sensitivity analyses were undertaken to explore the impact of key input parameters on the robustness of the model. The model structure was designed to be transferable to countries with different healthcare systems. Results Over the lifetime of the population (4,167,768 men; 4,129,961 women), the model estimated a gain of 62,722 years of life lived and 73,959 QALYs due to CHD prevention. Population genomic screening for FH would be cost-effective from a healthcare perspective if the cost per test was ≤AU$300 (∼US$233) which would yield an ICER AU$28,000 cost-saving. Conclusion Based on our model, offering population genomic screening to all young adults to detect FH could be cost-effective in the Australian healthcare system, at testing costs that are currently feasible. Funding Acknowledgement Type of funding sources: Foundation. Main funding source(s): This work was supported by the Australian National Heart Foundation and Monash University Faculty of Medicine, Nursing and Health Sciences Results from scenario analysesResults from Monte Carlo simulations
A capability based approach to enterprise transformation (2013)

The paper is about the drastic transformation of the strategy and business model of the Russian information technological enterprise which incorporates autonomous but interrelated business units: in 2001 top management of the IBS Company made the decision to switch to the information technology services and consulting area. The creation of new capabilities was the transformation objective. Capability based approach was successfully applied to achieve the transformation goals. An “ES/SoS nuclear model” has been introduced to describe the transformation. The model represents the enterprise as the “hard business nucleus” or kernel (major business-agents, who really make the business), a “soft business shell” (non-material environment: governing media, competences, knowledge, etc. - intangible assets), and the “cloud of extended enterprise” (clients, partners, etc., interlinked by common “across”-business processes). The great majority of transformation activities and outcomes lie in the ES/SoS's “soft shell” which includes new capabilities, governing relations, competences, etc.
[Flow cytometric analysis of the DNA content of sclerosing hemangioma of the lung]. (1993)

DNA ploidy and DNA content of two surgically resected sclerosing hemangioma of the lungs were examined by flow cytometry. Cell kinetics were analyzed by using DNA index and the proliferation index. Both cases were diploid, and their proliferation indices were 22.91 and 25.53, respectively, suggesting that they are benign tumors.