gebhart/patrepeval huggingface dataset:
Hash Based Encryption for Keyframes of Diagnostic Hysteroscopy (2017)

In this paper, we address the problem of confidentiality of keyframes, which are extracted from diagnostic hysteroscopy data using video summarization. We propose an image color coding method aimed at increasing the security of keyframes extracted from diagnostic hysteroscopy videos. In this regard, we use a 2-D logistic map to generate the cryptographic keys sequences, which relies on mixing and cascading the orbits of the chaotic map in order to generate the stream keys for the encryption algorithm. The encrypted images produced by our proposed algorithm exhibit randomness behavior, providing a high-level of security for the keyframes against various attacks. The experimental results and security analysis from different perspectives verify the superior security and high efficiency of our proposed encryption scheme compared to other state-of-the-art image encryption algorithms. Furthermore, the proposed method can be combined with mobile-cloud environments and can be generalized to ensure the security of cloud contents as well as important data during transmission.
Astronaut's Organ Doses Inferred from Measurements in a Human Phantom Outside the International Space Station (2009)

Space radiation hazards are recognized as a key concern for human space flight. For long-term interplanetary missions, they constitute a potentially limiting factor since current protection limits for low-Earth orbit missions may be approached or even exceeded. In such a situation, an accurate risk assessment requires knowledge of equivalent doses in critical radiosensitive organs rather than only skin doses or ambient doses from area monitoring. To achieve this, the MATROSHKA experiment uses a human phantom torso equipped with dedicated detector systems. We measured for the first time the doses from the diverse components of ionizing space radiation at the surface and at different locations inside the phantom positioned outside the International Space Station, thereby simulating an extravehicular activity of an astronaut. The relationships between the skin and organ absorbed doses obtained in such an exposure show a steep gradient between the doses in the uppermost layer of the skin and the deep organs with a ratio close to 20. This decrease due to the body self-shielding and a concomitant increase of the radiation quality factor by 1.7 highlight the complexities of an adequate dosimetry of space radiation. The depth-dose distributions established by MATROSHKA serve as benchmarks for space radiation models and radiation transport calculations that are needed for mission planning.
Computation of Two-dimensional Gravity Current (1995)

Computational results of a two-dimensional gravity current in a lock-exchange flow is presented in which a finite volume of homogeneous fluid was released instantaneously into another fluid of slightly lower density when a lock gate was opened. The computations were performed in a two-dimensional channel by solving the incompressible Navier-Stokes equation for an inhomogeneous fluid, the continuity equation and the transport equation for solute by the finite volume method. For accurate representation of small density difference, the density variation relative to the characteristic density difference was used as one of primitive variables. The finite volume formulation holds the conservative property with respect to mass at the boundaries as well as at the density interface so that the total mass of the two fluids with different density remains constant. Some of standard numerical schemes were used to examine their performance to the density jump of the interface. The computed gravity current moves steadily in an initial phase, and the front speed decreases with distance in a self-similar phase when an internal bore on the interface reflected from the back of the lock reaches the front of the current. The effects of the bottom boundary layer on the internal structure of the current is investigated from numerical experiments with no slip and free-slip boundary conditions. The volume of the diluted fluid in a gravity current by the entrainment of ambient fluid is evaluated as a function of time to quantify the mixing. The result indicates that at low Reynolds numbers the subsequent mixing occurs in the early stage of the evolution of the gravity current in a lock-exchange flow.
Internal-model-based design of repetitive and iterative learning controllers for linear multivariable systems (2000)

Repetitive and iterative learning control are two modern control strategies for tracking systems in which the signals are periodic in nature. This paper discusses repetitive and iterative learning control from an internal model principle point of view. This allows the formulation of existence conditions for multivariable implementations of repetitive and learning control. It is shown that repetitive control can be realized by an implementation of a robust servomechanism controller that uses the appropriate internal model for periodic distrubances. The design of such controllers is discussed. Next it is shown that iterative learning control can be implemented in the format of a disturbance observer/compensator. It is shown that the resulting control structure is dual to the repetitive controller, and that both constitute an implementation of the internal model principle. Consequently, the analysis and design of repetitive and iterative learning control can be generalized to the powerful analysis and design procedure of the internal model framework, allowing to trade-off the convergence speed for periodic-disturbance cancellation versus other control objectives, such as stochastic disturbance suppression.
Value of Examination of the Gastric Aspirate for the Diagnosis of Neonatal Infection (1994)

To evaluate the interest of examination of the gastric aspirate (GA) as a contribution to decision making of initial antimicrobial therapy, all 3,989 neonates delivered in Orléans Maternity Hospital in 1990 have been studied. Microscopic examination: polymorphonuclear leukocytes (PMN) were, respectively, absent/present/abundant in 180/130/25 treated (T) and in 2,567/1,032/90 untreated (NT) newborns. PMN were demonstrated in 2/5 documented, 4/6 obvious, 2/2 suspected and 34/58 possible infections. Bacteria were, respectively, absent/present/abundant in 201/109/46 T newborns and in 2,722/877/56 NT newborns. Bacteria were demonstrated in 3/5 documented, 4/6 obvious, 2/2 suspected and 32/58 possible infections. Culture: the number of initially T and NT newborns was, respectively, for each bacterial species: Enterobacteriaceae 33/294, streptococci B (GBS), D and alpha-hemolytic 60/107, 12/110 and 18/70, Streptococcus pneumoniae 2/2, anaerobes 12/402, Listeria 3/0, Haemophilus species 4/4, Staphylococcus aureus 5/7, coagulase-negative staphylococci 25/1335, Lactobacillus 14/345, corynebacteria 10/196. In the 5 newborns with documented early onset meningitis and/or septicemia, 3 grew with GBS, Escherichia coli and Listeria. In the 4 newborns (2 meningitis and 2 urinary tract infections) with late-onset infection, no positive GA could be demonstrated. Although microscopic examination and cultures were statistically more frequently positive in T newborns, with variations dependent on the species of bacteria, more newborns without infection were colonized whatever the bacteria. Thus, bacteriological results of GA, if considered out of the clinical context, cannot be an argument for treatment.
Chemical Vapor Deposition Epitaxy of Silicon-based Materials using Neopentasilane (2008)

Neopentasilane (Si5H12) has been used as a precursor for the chemical vapor deposition epitaxy of silicon and Si1-yCy alloys at temperatures from 550 to 700 oC. This paper summarizes the experimental findings of high growth rates of high quality epitaxy and planar films and then proposes mechanisms to support these observations. Concerted mechanisms, which can lead to growth without the usual requirement of open sites on an otherwise hydrogen covered surface are described as they relate to high -order silanes.
Serological markers of extracellular matrix remodeling predict transplant‐free survival in primary sclerosing cholangitis (2018)

Extracellular matrix remodeling is elevated in primary sclerosing cholangitis patients compared to ulcerative colitis patients. Furthermore, the interstitial matrix marker PRO-C3 was identified as a potent prognostic marker and an independent predictor of transplant-free survival in primary sclerosing cholangitis.
Legends for Supplemental Figures from Novel Predictors of Breast Cancer Survival Derived from miRNA Activity Analysis (2023)

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Cycling Toward Leukemia Stem Cell Elimination Wtih a Selective Sonic Hedgehog Antagonist, (2011)

Abstract Abstract 3776 Cumulative evidence suggests that dormant self-renewing leukemia stem cells (LSC) contribute to relapse and blast crisis transformation by evading therapies that target cycling cells. Previously, sonic hedgehog (Shh) signaling was shown to modulate cell cycle regulation and self-renewal in normal mouse hematopoietic stem cells. However, its role in human LSC regeneration and quiescence had not been elucidated. Here we investigated the role of Shh signaling in maintenance of dormancy. We show that, compared to chronic phase CML and normal progenitors, human blast crisis LSC harbor enhanced expression of the Shh transcriptional activator, GLI2, and decreased expression of a transcriptional repressor, GLI3. Treatment of human blast crisis LSC engrafted RAG2−/−gc−/− mice with a selective Shh inhibitor, PF-04449913, reduced leukemic burden in a niche-dependent manner commensurate with GLI downregulation. Full transcriptome RNA sequencing performed on FACS-purified human progenitors from PF-04449913 treated blast crisis LSC engrafted mice demonstrated greater Shh gene splice isoform concordance with normal progenitors than vehicle treated controls. In addition, RNA sequencing revealed significantly decreased cell cycle regulatory genes expression and splice isoform analysis demonstrated reversion towards a normal splice isoform signature for many cell cycle regulatory genes. Moreover, cell cycle FACS analysis showed that selective Shh inhibition permitted dormant blast crisis LSC to enter the cell cycle while normal progenitor cell cycle status was unaffected. Finally, PF-04449913 synergized with BCR-ABL inhibition to reduce blast crisis LSC survival and self-renewal in concert with increased expression of Shh pathway regulators. Our findings suggest that selective Shh antagonism induces cycling of dormant human blast crisis LSC, rendering them susceptible to BCR-ABL inhibition, while sparing normal progenitors. Implementation of novel LSC splice isoform detection platforms to assess efficacy of Shh inhibitor-mediated sensitization to molecularly targeted therapy may inform dormant cancer stem cell elimination strategies that ultimately avert relapse. Disclosures: Levin: Pfizer Oncology: Employment; Pfizer Oncology: Equity Ownership.
Implementing AASB 15 revenue from contracts with customers: the preparer perspective (2019)

Purpose This study aims to examine the implementation of AASB 15 Revenue from Contracts with Customers to provide insight into preparers’ perspectives on the challenges, costs and benefits experienced in implementing a new and complex standard. Design/methodology/approach The study uses a survey of 143 financial statement preparers engaged in implementing AASB 15. Findings The results reveal significant variation in the approach to, and progress in, implementing AASB 15. Research limitations/implications The study provides evidence of the role of proprietary costs in implementing a new standard and suggests that preparers adopt a more pragmatic view of the nature of compliance compared to standard-setters. Practical implications The evidence in this study strongly suggests that there is little to be gained in deferring effective dates for new standards. It suggests that standard-setters can motivate entities by framing a standard in terms of how it improves the business itself, rather than from a compliance framing. Originality/value This study provides a rare perspective on the actual implementation experience of preparers confronted with the introduction of a new standard. Such a perspective is of value to standard-setters and preparers and offers insight to researchers that cannot be gained from traditional capital market archival approaches.
Peptidyl-prolyl Isomerase Pin1 Controls Down-regulation of Conventional Protein Kinase C Isozymes (2012)

The down-regulation or cellular depletion of protein kinase C (PKC) attendant to prolonged activation by phorbol esters is a widely described property of this key family of signaling enzymes. However, neither the mechanism of down-regulation nor whether this mechanism occurs following stimulation by physiological agonists is known. Here we show that the peptidyl-prolyl isomerase Pin1 provides a timer for the lifetime of conventional PKC isozymes, converting the enzymes into a species that can be dephosphorylated and ubiquitinated following activation induced by either phorbol esters or natural agonists. The regulation by Pin1 requires both the catalytic activity of the isomerase and the presence of a Pro immediately following the phosphorylated Thr of the turn motif phosphorylation site, one of two C-terminal sites that is phosphorylated during the maturation of PKC isozymes. Furthermore, the second C-terminal phosphorylation site, the hydrophobic motif, docks Pin1 to PKC. Our data are consistent with a model in which Pin1 binds the hydrophobic motif of conventional PKC isozymes to catalyze the isomerization of the phospho-Thr-Pro peptide bond at the turn motif, thus converting these PKC isozymes into species that can be efficiently down-regulated following activation.
Features of condensation of 4,4′-Dihydroxybiphenyl with phenylphosphonous tetraethyldiamide (2007)

4,4′-Dihydroxybiphenyl was condensed with phenylphosphonous tetraethyldiamide. The moleccular mass, chemical composition, and structural features of the product, oligo(4,4′-biphenylene phenylphosphonite), were elucidated using the method of matrix-activated laser desorption/ionization, with a time-of-flight (TOF) mass analyzer. The oligophenylphosphites containing labile P-N bond, which are unstable under conditions of recording mass spectra, were stabilized by conversion into oligophenylphosphonates. 1H-Tetrazole catalyzes the reaction of phenylphosphonous tetraethyldiamide with 4,4′-dihydroxybiphenyl. Cross-linking in the solid state of the oligo(4,4′-biphenylene phenylphosphonite) containing terminal phosphonamidite group leads to gradual increase in the molecular weight and is accompanied by redox processes.
ChemInform Abstract: ON THE MECHANISM OF PHOTOLYSIS OF 4‐PHENYL‐1,3,2‐OXATHIAZOLYLIO‐5‐OXIDE IN ETHANOL. EVIDENCE FOR KETENE INTERMEDIATES (1977)

Abstract Die Photolyse der Titelverbindung (I) in Äthanol in Gegenwart von Sauerstoff ergibt neben Benzonitril (Ausbeute 21%) in konkurrierender Reaktion über das Keten (II) und ein Radikal das Glyoxylat (IV).
A Novel Polyaminocarboxylate Compound To Treat Murine Pulmonary Aspergillosis by Interfering with Zinc Metabolism (2018)

<i>Aspergillus fumigatus</i> can cause pulmonary aspergillosis in immunocompromised patients and is associated with a high mortality rate due to a lack of reliable treatment options. This opportunistic pathogen requires zinc in order to grow and cause disease. Novel compounds that interfere with fungal zinc metabolism may therefore be of therapeutic interest. We screened chemical libraries containing 59,223 small molecules using a resazurin assay that compared their effects on an <i>A. fumigatus</i> wild-type strain grown under zinc-limiting conditions and on a zinc transporter knockout strain grown under zinc-replete conditions to identify compounds affecting zinc metabolism. After a first screen, 116 molecules were selected whose inhibitory effects on fungal growth were further tested by using luminescence assays and hyphal length measurements to confirm their activity, as well as by toxicity assays on HeLa cells and mice. Six compounds were selected following a rescreening, of which two were pyrazolones, two were porphyrins, and two were polyaminocarboxylates. All three groups showed good <i>in vitro</i> activity, but only one of the polyaminocarboxylates was able to significantly improve the survival of immunosuppressed mice suffering from pulmonary aspergillosis. This two-tier screening approach led us to the identification of a novel small molecule with <i>in vivo</i> fungicidal effects and low murine toxicity that may lead to the development of new treatment options for fungal infections by administration of this compound either as a monotherapy or as part of a combination therapy.
Distributed concurrency control with limited wait-depth (2003)

Distributed wait-depth-limited (DWDL) concurrency control, a locking-based method that limits the wait-depth of blocked transactions to one, which assures that deadlocks are resolved as part of regular transaction processing is described. The performance of DWDL is compared with that of distributed two-phase locking (2PL) and the wound-wait concurrency control method through a detailed simulated. Results show that DWDL behaves similarly to 2PL for low data contention levels, but at high lock contention levels, DWDL outperforms the other methods to a significant degree.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Deformable registration of the planning image (kVCT) and the daily images (MVCT) for adaptive radiation therapy (2006)

The incorporation of daily images into the radiotherapy process leads to adaptive radiation therapy (ART), in which the treatment is evaluated periodically and the plan is adaptively modified for the remaining course of radiotherapy. Deformable registration between the planning image and the daily images is a key component of ART. In this paper, we report our researches on deformable registration between the planning kVCT and the daily MVCT image sets. The method is based on a fast intensity-based free-form deformable registration technique. Considering the noise and contrast resolution differences between the kVCT and the MVCT, an 'edge-preserving smoothing' is applied to the MVCT image prior to the deformable registration process. We retrospectively studied daily MVCT images from commercial TomoTherapy machines from different clinical centers. The data set includes five head-neck cases, one pelvis case, two lung cases and one prostate case. Each case has one kVCT image and 20-40 MVCT images. We registered the MVCT images with their corresponding kVCT image. The similarity measures and visual inspections of contour matches by physicians validated this technique. The applications of deformable registration in ART, including 'deformable dose accumulation', 'automatic re-contouring' and 'tumour growth/regression evaluation' throughout the course of radiotherapy are also studied.
Evaluation of Some Fungi and Bacteria for Potential Control of Safflower Rust (1994)

Abstract Some fungal and bacterial isolates applied as soil and seed treatments in greenhouse trials gave a good protection against Puccinia carthami Cda. on safflower, significantly reducing the infection from rust‐infested seeds. Trichoderma viride and T. harzianum added alone and in combination as air‐dried inoculum to the soil were the most effective fungal isolates. However T. viride at two higher rates reduced the rate of emergence of safflower seedlings. Among bacteria, Bacillus subtilis, B. cereus , isolates of Pseudomonas fluorescens and B. thuringiensis reduced rust infection when added both as soil drench and as seed treatment. Good results in the biocontrol of P. carthami were also obtained with some combination antagonist treatments such as T. viride + B. cereus, T. viride + P. fluorescens (16), T. viride + T. harzianum + B. cereus and T. viride +, T. harzianum + P. fluorescens (16). Fungal isolates added as soil treatment increased seedling length, whereas no similar effects were observed when these isolates were applied as seed treatment.
Thermal annealing effects on copper microstructure in Through-Silicon-Vias (2016)

In this paper, we have studied the microstructure evolution of one-year room-temperature-aged Through-Silicon Via (TSV) copper after annealing the TSV samples at 300 °C, 400 °C and 500 °C for 180 minutes. Hardness and elastic modulus values are obtained by using nano-indentation technique. The hardness and elastic modulus values decrease as annealing temperature increases. The microstructure of copper (Cu) is examined to obtain grain size and texture, using electron backscatter diffraction (EBSD). Copper grain growth, if any, is studied under different annealing temperatures. There was no observable grain growth for the annealing temperatures studied in this work. Moreover, microstructure variation at different locations within a Cu TSV is also studied.
Issues Pertinent to the in Vivo in Situ Spin Trapping of Free Radicals (1998)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIssues Pertinent to the in Vivo in Situ Spin Trapping of Free Radicals§Sovitj Pou, Howard J. Halpern, Pei Tsai, and Gerald M. RosenView Author Information Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland 21201, and Department of Radiation and Cellular Oncology, The University of Chicago, Chicago, Illinois 60637 Cite this: Acc. Chem. Res. 1999, 32, 2, 155–161Publication Date (Web):November 4, 1998Publication History Received26 February 1998Published online4 November 1998Published inissue 1 February 1999https://pubs.acs.org/doi/10.1021/ar970251lhttps://doi.org/10.1021/ar970251lresearch-articleACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views281Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Electron paramagnetic resonance spectroscopy,Free radicals,Nitrogen compounds,Oxides,Quantum mechanics Get e-Alerts
First‐time shoulder dislocation: High prevalence of labral injury and age‐related differences revealed by MR arthrography (2007)

A high prevalence and wide variety of labral avulsions after first-time shoulder dislocation, especially adherent ALPSA, inferiorly displaced avulsed labrum, or GLAD lesion, may influence treatment choice and outcome, suggesting a role for early MRA to assist in treatment triage.