gebhart/patrepeval huggingface dataset:
Difluoromethylbenzoxazole Pyrimidine Thioether Derivatives: A Novel Class of Potent Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors (2011)

This paper reports the synthesis and antiviral properties of new difluoromethylbenzoxazole (DFMB) pyrimidine thioether derivatives as non-nucleoside HIV-1 reverse transcriptase inhibitors. By use of a combination of structural biology study and traditional medicinal chemistry, several members of this novel class were synthesized using a single electron transfer chain process (radical nucleophilic substitution, S(RN)1) and were found to be potent against wild-type HIV-1 reverse transcriptase, with low cytotoxicity but with moderate activity against drug-resistant strains. The most promising compound 24 showed a significant EC(50) value close to 6.4 nM against HIV-1 IIIB, a moderate EC(50) value close to 54 μM against an NNRTI resistant double mutant (K103N + Y181C), but an excellent selectivity index >15477 (CC(50) > 100 μM).
Reversible Deficiency of Antimicrobial Polypeptides in Bacterial Vaginosis (2006)

Bacterial vaginosis is a common condition associated with increased risk of sexually transmitted diseases, including human immunodeficiency virus infections. In contrast, vulvovaginal candidiasis has a much weaker association with sexually transmitted diseases. We found that vaginal lavage fluid from women with bacterial vaginosis is deficient in antimicrobial polypeptides and antimicrobial activity compared to fluid from healthy women or women with vulvovaginal candidiasis. Effective treatment normalized the concentrations of antimicrobial polypeptides in both bacterial vaginosis and in vulvovaginal candidiasis, suggesting that the abnormalities were a result of the diseases. Unlike in vulvovaginal candidiasis, the neutrophil attractant chemokine interleukin-8 (IL-8) was not increased in bacterial vaginosis, accounting for low concentrations of neutrophil-derived defensins in vaginal fluid. In organotypic cultures of human vaginal epithelium containing dendritic cells, treatment with Lactobacillus jensenii, a typical vaginal resident, induced the synthesis of IL-8 mRNA and the epithelial human beta-defensin-2 mRNA, but a typical bacterial vaginosis pathogen, Gardnerella vaginalis, had no effect. When the two bacteria were combined, Gardnerella vaginalis did not interfere with the immunostimulatory effect of Lactobacillus jensenii. The loss of normal immunostimulatory flora in bacterial vaginosis is thus associated with a local deficiency of multiple innate immune factors, and this deficiency could predispose individuals to sexually transmitted diseases.
The Power and Energy Initiative at the University of Pittsburgh: Addressing the aging workforce issue through innovative education, collaborative research, and industry partnerships (2010)

The Power & Energy Initiative in the Swanson School of Engineering at the University of Pittsburgh (Pitt) is partnering with regional industry to provide innovative education and collaborative research programs in the areas of electric power, nuclear, and mining engineering. Working together with industry, along with strong government sponsorship and other constituency support, Pitt is contributing to solutions that address the aging workforce issue in the power and energy sector, as well as to advances in technology development, research transition, and outreach. Industry champions include Eaton Corporation, Westinghouse Electric Co., and CONSOL Energy. In addition, Pitt is playing an active role nationally through leadership involvement in the IEEE PES Power & Energy Engineering Workforce Collaborative, and is establishing a model program for the resurgence and sustainability of university based electric power and energy programs.
Angiotensin‐converting enzyme inhibition prevents myocardial infarction‐induced increase in renal cortical cGMP and cAMP phosphodiesterase activities (2015)

We investigated whether myocardial infarction (MI) enhances renal phosphodiesterases (PDE) activities, investigating particularly the relative contribution of PDE1-5 isozymes in total PDE activity involved in both cGMP and cAMP pathways, and whether angiotensin-converting enzyme inhibition (ACEi) decreases such renal PDE hyperactivities. We also investigated whether ACEi might thereby improve atrial natriuretic peptide (ANP) efficiency. We studied renal cortical PDE1-5 isozyme activities in sham (SH)-operated, MI rats and in MI rats treated with perindopril (ACEi) 1 month after coronary artery ligation. Circulating atrial natriuretic peptide (ANP), its second intracellular messenger cyclic guanosine monophosphate (cGMP) and cGMP/ANP ratio were also determined. Cortical cGMP-PDE2 (80.3 vs. 65.1 pmol/min/mg) and cGMP-PDE1 (50.7 vs. 30.1 pmol/min/mg), and cAMP-PDE2 (161 vs. 104.1 pmol/min/mg) and cAMP-PDE4 (307.5 vs. 197.2 pmol/min/mg) activities were higher in MI than in SH rats. Despite increased ANP plasma level, ANP efficiency tended to be decreased in MI compared to SH rats. Perindopril restored PDE activities and tended to improve ANP efficiency in MI rats. One month after coronary ligation, perindopril treatment of MI rats prevents the increase in renal cortical PDE activities. This may contribute to increase renal ANP efficiency in MI rats.
Pan frying of meat patties. : 2. Influence of processing conditions on heat transfer, crust color formation, cooking losses and sensory quality (1979)

Pan frying of meat patties. : 2. Influence of processing conditions on heat transfer, crust color formation, cooking losses and sensory quality
Kinetics of Incorporation of Structural Proteins into Sindbis Virions (1969)

The morphogenesis of Sindbis virus was studied by determining the kinetics with which newly synthesized nucleocapsid and envelope proteins appeared in virions released into the extracellular medium. Assembly of the nucleocapsid was more rapid than modification of the cellular membrane by the addition of the viral envelope protein. However, both viral structural proteins were efficiently incorporated into virions; a 0.5-hr pulse-labeling period resulted in the release of maximally labeled virus during the next hour. When protein synthesis was inhibited, release of virus soon declined even though large amounts of both viral structural proteins were present within the cell and ribonucleic acid replication was unaffected.
The impact of COVID-19 pandemic on the quality of life of healthcare workers and the associated factors: A systematic review (2022)

COVID-19 frontline workers perceived lower quality of life, which was mainly associated with psychological states such as the aforementioned besides to working conditions like not being previously trained in COVID-19 cases. On the other hand, social support, resilience and active coping could improved their quality of life.
Spider web biomonitoring as a tool to quantify sources of potentially toxic elements in urban dust (2022)

Pollution has been stated as one of the major challenges to modern humankind [1]. In the face of growing urbanization, air quality and especially urban particulate matter (PM) are key aspects [2]. Since classical air quality monitoring does often include none or only few potentially toxic elements (PTE), biomonitoring -the sampling and analysis of biological materials -might be a useful complement or even inexpensive standalone technique.
Supplementary Figure 1 from PML/RARα-Regulated miR-181a/b Cluster Targets the Tumor Suppressor RASSF1A in Acute Promyelocytic Leukemia (2023)

&lt;p&gt;A, Apoptosis assay in NB4 cells 24h and 48h after application of As2O3 (1 µM). B, FACS analysis for CD11b expression in As2O3 treated NB4 cells 48h after application. C, qPCR analysis for C/EBPβ mRNA expression in NB4 cells after As2O3 application. D, Apoptosis assay in NB4 cells 48h after application of doxorubicin (0.01 µg/ml) with or without cytarabine (0.05 µM). E, qPCR analys for C/EBPβ mRNA expression in NB4 cells after doxorubicin and cytarabine application. For qPCR measurement GAPDH was used as control. Bars and values in the dot blots represent the median {plus minus} SD from three independent experiments.* p-value {less than or equal to} 0.05; ** p-value {less than or equal to} 0.01.&lt;/p&gt;
ANALYSIS OF THE AUTOSOMAL MUTATION abo AND ITS INTERACTION WITH THE RIBOSOMAL DNA OF DROSOPHILA MELANOGASTER: THE ROLE OF X-CHROMOSOME HETEROCHROMATIN (1980)

The autosomal recessive, maternal-effect mutation abnormal oocyte (abo: 2-38) preferentially lowers the viability os XO progeny. The severity of the sex-ratio distortion is reduced by duplications of maternal or zygotic heterochromatin (SANDLER 1970, 1977; PARRY and SANDLER 1974). Utilizing X-chromosome inversions that contain modifications in the quantity and arrangement of the heterochromatic functions, Xhabo and cr+, wer have extended our investigations of abo's influence on XO male recovery and rDNA redundancy (KRIDER, YEDVOBNICK and LEVINE 1979).--XO males bearing In(1)SCS1LSC4R or In(1)Wm4LSC4R are recovered twice as frequently as X chromosomes containing a single Xh region, implying that these inversions possess a duplication of Xhabo. abo mutant females heterozygous for In(1)SCS1LSC4R and wild-type X chromosomes generate XO progeny that do not contain elevated rDNA redundancies. XO males containing In(1)Wm4 exhibit male recoveries and rDNA elevations similar to those of males bearing a wild-type X chromosome, when both derive from a common abo/abo mother. Reciprocal crosses baetween In(1)Wm4 and Canton-S males to attached-X abo females show significant, though reuduced, sex ratios in the absence of an rDNA effect. The observation that abo can elevate the rDNA redundancy of In(1)Wm4, a chromosome that does not compensate, suggests that abo and cr+ functions are not directly related.
A metric for layout-friendly microarchitecture optimization in high-level synthesis (2012)

In this work we address the problem of managing interconnect timing in high-level synthesis by generating a layout-friendly microarchitecture. A metric called spreading score is proposed to evaluate the layout-friendliness of microarchitectural netlist structures. For a piece of connected netlist, spreading score measures how far the components can be spread from each other with bounded length for every wire. The intuition is that components in a layout-friendly netlist (e.g., a mesh) can spread over the layout region without introducing long interconnects. We propose a semidefinite programming relaxation to allow efficient estimation of spreading score, and use it in a high-level synthesis tool. On a number of test cases, a normalized spreading score shows a stronger bias in favor of interconnect structures that have better timing after layout, compared to the widely used metric of total multiplexer inputs. We also justify our metric and motivate further study by relating spreading score to other metrics and problems for layout-friendly synthesis.
Nahrungskarenz im Kreißsaal - Ein traditioneller Qualitätsstandard auf dem Prüfstand (2007)

Numerous scientific case reports and observational studies, including that of Curtis Mendelson with its great historical relevance, have reported the problem of aspiration pneumonitis during labour. Because of this, strict fasting prior to delivery to reduce pulmonary aspiration has been doctrine since the 1940s. However, maternal mortality from anaesthesia, particularly from aspiration, has dropped dramatically over recent decades. This is due both to far-reaching improved quality of care as well as technical progress in anaesthesia, which increasingly challenge the scientific basis for fasting in obstetric anaesthesia. Strict fasting has never been proven to reduce morbidity or mortality in labouring women. Because of the physiological and anatomical changes of pregnancy, gastric emptying is theoretically prolonged, and therefore the risk of aspiration is assumed to be increased. However, the available data with patients receiving clear fluids run contrary to this assumption, or at least dispute its clinical relevance. Recent studies report positive influence of reduced fasting time on both maternal comfort and maternal/fetal metabolism without increased risk. This has already led to meaningful discussion regarding a corresponding change in official recommendations.
Improving the operation and maintenance of wind farms: determination of wind turbine (2008)

To improve the economic and technical wind farm operation is necessary an accurate determination of wind turbine performance. To do so it is necessary to estimate the unavailability and the efficiency of each wind turbine.
Semi-Supervised Learning For Cardiac Left Ventricle Segmentation Using Conditional Deep Generative Models as Prior (2019)

Accurate segmentation of left ventricle (LV) in apical four chamber echocardiography cine is a key step in cardiac functionality assessment. Cardiologists roughly annotate two frames in the cardiac cycle, namely, the end-diastolic and end-systolic frames, as part of their clinical workflow, limiting the annotated data to less than 5% of the frames in the cardiac cycle. In this paper, we propose a semi-supervised learning algorithm to leverage the unlabeled data to improve the performance of LV segmentation algorithms. This approach is based on a generative model which learns an inverse mapping from segmentation masks to their corresponding echo frames. This generator is then used as a critic to assess and improve the LV segmentation mask generated by a given segmentation algorithm such as U-Net. This semi-supervised approach enforces a prior on the segmentation model based on the perceptual similarity of the generated frame with the original frame. This approach promotes utilization of the unlabeled samples, which, in turn, improves the segmentation accuracy.
Delayed Administration of Basic Fibroblast Growth Factor (bFGF) Attenuates Cognitive Dysfunction Following Parasagittal Fluid Percussion Brain Injury in the Rat (1997)

The present study evaluates the therapeutic effects of delayed administration of bFGF on cognitive dysfunction and histopathological damage following lateral fluid-percussion (FP) brain injury. Male Sprague-Dawley rats were trained to learn a visuospatial task in a Morris Water Maze (MWM) paradigm and then were anesthetized and subjected to either FP brain injury of moderate severity (2.5-2.8 atm, n = 32) or surgery without brain injury (n = 10). Twenty-four hours postinjury, an infusion cannula connected to a mini-osmotic pump was implanted into the area of maximal cortical injury to continuously infuse either bFGF (2.0 g) or vehicle for 7 days. Treatment with bFGF significantly attenuated posttraumatic memory dysfunction in the MWM at 8 days postinjury when compared to vehicle treatment (p < 0.05). The cortical lesion and significant cell loss in the ipsilateral CA3 region of the hippocampus, produced by FP injury, was not affected by bFGF treatment. However, immunohistochemical evaluation of glial fibrillary acidic protein revealed a trend toward increased astrocytosis in the injured cortex of bFGF-treated animals compared to vehicle-treated animals (p < 0.1). These results indicate that bFGF may be efficacious in attenuating cognitive dysfunction associated with traumatic brain injury.
On the System-Level Performance of Coordinated Multi-Point Transmission Schemes in 5G NR Deployment Scenarios (2019)

This paper investigates the system-level performance of dynamic point selection (DPS) and non-coherent joint transmission (NC-JT) coordinated multi-point transmission (CoMP) schemes under different 5G NR deployment scenarios using state-of-the-art system-level simulations. It is observed that at a mid-band carrier frequency, NC-JT does not provide performance gains over DPS or single transmission/reception point (TRP) transmission unless the channel from a TRP is rank deficient. Therefore, benefits with NC-JT are more likely to be found in indoor deployment scenarios where the TRPs are typically equipped with only 2 transmit antenna ports, whereas benefits are less likely to be observed in macro-cell deployments where TRPs typically have a larger number of antennas ports. It is further observed that NC-JT gains tend to diminish with increasing system load, partly due to increased interference, which typically lowers the transmission rank.
Capillary Penetration of Fibrous Materials (1934)

ADVERTISEMENT RETURN TO ISSUEArticleNEXTCapillary Penetration of Fibrous MaterialsR. L. Peek Jr. and D. A. McLeanCite this: Ind. Eng. Chem. Anal. Ed. 1934, 6, 2, 85–90Publication Date (Print):March 1, 1934Publication History Published online1 May 2002Published inissue 1 March 1934https://pubs.acs.org/doi/10.1021/ac50088a001https://doi.org/10.1021/ac50088a001research-articleACS PublicationsRequest reuse permissionsArticle Views317Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Automobile Navigation System with Multi-Source Guide Information (1992)

&lt;div class="htmlview paragraph"&gt;This paper describes an Automobile Navigation System with Multi-Source Guide Information. One of the features of this system is accurate location detection, which uses refined map-matching method incorporating a high accuracy rotation sensor, Fiber Optic Gyroscope (FOG). The system shows the position of the vehicle on a CRT map display and can also provide useful information, such as the locations of hotels, golf courses, etc., by using a CD-ROM disc.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;In addition to this information, this system can play CD-ROM discs based on the CDCRAFT standard. By means of this standard, software vendors can produce multimedia entertainment, such as a sightseeing guide with voice. Also, this system can display road and traffic information from the roadside radio beacons of the Vehicle Information &amp;amp; Communication System (VICS).&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;This navigation system has been installed in Nissan's 1991 model Cedric, Gloria and CIMA.&lt;/div&gt;
Isolation of a New Antibiotic, Alaremycin, Structurally Related to 5-Aminolevulinic Acid fromStreptomycessp. A012304 (2005)

A new antibiotic, which is structurally related to 5-aminolevulinic acid, a precursor of heme biosynthesis, and named alaremycin, was isolated from the culture broth of an actinomycete strain through a random screening with the blue assay to detect the formation of anucleate cells in Escherichia coli. The producing strain was identified as Streptomyces sp. by morphological, physiological, chemical and genetic criteria. Alaremycin was purified from the culture supernatant by HP-20 hydrophobic-interaction chromatography, sequential solvent/water extraction in the acidic or alkaline pH range, and QMA cation-exchange chromatography. The chemical structure of alaremycin was determined as 5-acetamido-4-oxo-5-hexenoic acid by analyses of mass and NMR spectra. The antibacterial activity of alaremycin was enhanced in the presence of 5-aminolevulinic acid.
PAK signaling in cancer (2012)

Transformation of a normal cell to a cancer cell is caused by mutations in genes that regulate proliferation, apoptosis, and invasion. Small GTPases such as Ras, Rho, Rac and Cdc42 orchestrate many of the signals that are required for malignant transformation. The p21-activated kinases (PAKs) are effectors of Rac and Cdc42. PAKs are a family of serine/threonine protein kinases comprised of six isoforms (PAK1-6), and they play important roles in cytoskeletal dynamics, cell survival and proliferation. They act as key signal transducers in several cancer signaling pathways, including Ras, Raf, NFκB, Akt, Bad and p53. Although PAKs are not mutated in cancers, they are overexpressed, hyperactivated or amplified in several human tumors and their role in cell transformation make them attractive therapeutic targets. This review discusses the evidence that PAK is important for cell transformation and some key signaling pathways it regulates. This review primarily discusses Group I PAKs (PAK1, PAK2 and PAK3) as Group II PAKs (PAK4, PAK5 and PAK6) are discussed elsewhere in this issue (by Minden).
The Stability and Shelf Life of Food Ed. 2 (2016)

The second edition of The Stability and Shelf-life of Food is a fully revised and thoroughly updated edition of this highly-successful book. This new edition covers methods for shelf-life and stability evaluation, reviewing the modelling and testing of the deterioration of products as well as the use of sensory evaluation methods for testing food spoilage. The first part of the book focuses on deteriorative processes and factors influencing shelf-life, covering aspects such as chemical deterioration, physical instability and microbiological spoilage. The effects of process and packaging on the stability and shelf-life of products are also covered in this part. Part Two reviews the methods for shelf life and stability evaluation. These include sensory evaluation methods and instrumental methods to determine food quality deterioration. The final section of the book covers stability of important ingredient categories, from oils and fats, to beverages such as beer, wine, coffee and fruit juices, in addition to bakery products and meats. With updated chapters reflecting advances made in the field and with the addition of new chapters covering the stability and shelf-life a variety of products, this new edition will provide the latest research for both academics working in the field of food quality as well as providing essential information for food scientists working in industry.Thoroughly revised and updated edition of a very popular and well regarded bookIncludes dedicated chapters covering the shelf-life and stability of specific products making this book ideal for those working in industryPresents a wide coverage of the processes and factors influencing shelf-life, the evaluation of stability and shelf-life and the stability and shelf-life of particular products makes this book valuable for both academics and those working in industry
Porphyrin Dyes with High Injection and Low Recombination for Highly Efficient Mesoscopic Dye-Sensitized Solar Cells (2011)

The photovoltaic performance and charge recombination characteristics of porphyrin-based dye-sensitized solar cell (DSC) devices have been investigated using the impedance spectroscopy (IS) technique. The IS results provide key information related to the device performance for a highly efficient porphyrin dye (YD2), a reference porphyrin dye (YD0), and a commercial ruthenium dye (N719). The DSC devices constructed using YD2 and N719 dyes reach similar internal power conversion efficiencies (7.41% vs 7.54%) due to the higher injection of the YD2 dye that is compromised by a lower photovoltage. In addition, both YD2 and N719 dyes exhibit the same charge-transfer resistance, indicating that the recombination rates of both dyes are very similar. The diarylamino group plays a key role to repel the triiodide ions from the titania surface so that the charge recombination of YD2 is less significant compared with that of YD0.