gebhart/patrepeval huggingface dataset:
Integrative big transcriptomics data analysis implicates crucial role of MUC13 in pancreatic cancer (2023)

Big data analysis holds a considerable influence on several aspects of biomedical health science. It permits healthcare providers to gain insights from large and complex datasets, leading to improvements in the understanding, diagnosis, medication, and restraint of pathological conditions including cancer. The incidences of pancreatic cancer (PanCa) are sharply rising, and it will become the second leading cause of cancer related deaths by 2030. Various traditional biomarkers are currently in use but are not optimal in sensitivity and specificity. Herein, we determine the role of a new transmembrane glycoprotein, MUC13, as a potential biomarker of pancreatic ductal adenocarcinoma (PDAC) by using integrative big data mining and transcriptomic approaches. This study is helpful to identify and appropriately segment the data related to MUC13, which are scattered in various data sets. The assembling of the meaningful data, representation strategy was used to investigate the MUC13 associated information for the better understanding regarding its structural, expression profiling, genomic variants, phosphorylation motifs, and functional enrichment pathways. For further in-depth investigation, we have adopted several popular transcriptomic methods like DEGseq2, coding and non-coding transcript, single cell seq analysis, and functional enrichment analysis. All these analyzes suggest the presence of three nonsense MUC13 genomic transcripts, two protein transcripts, short MUC13 (s-MUC13, non-tumorigenic or ntMUC13), and long MUC13 (L-MUC13, tumorigenic or tMUC13), several important phosphorylation sites in tMUC13. Altogether, this data confirms that importance of tMUC13 as a potential biomarker, therapeutic target of PanCa, and its significance in pancreatic pathobiology.
Building Trust for Interactive E-Learning (2005)

Learners, tutors and service providers are the basic players in an e-learning system. Similar to the situation in traditional campus education, “trust” composes the interaction baselines between each of these players. Although the establishment processes are different, the requirements and importance of “trust” are the same whether the situation is traditional education or remote e-learning.
A multi-disciplinary approach to the management of NAFLD improves both liver and metabolic health and is cost effective (2018)

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
Bactericidal activity of gemifloxacin and other quinolones against Streptococcus pneumoniae (2000)

This study compared the bactericidal activity of gemifloxacin (SB-265805) and a panel of test quinolones against two ciprofloxacin-resistant pneumococcal strains (Streptococcus pneumoniae 502226 and 503244) and one ciprofloxacin-sensitive strain (S. pneumoniae C3LN4). Activities were compared by calculating the bactericidal index of these agents. Gemifloxacin was found to be the most bactericidal quinolone tested against these strains. This finding confirms previous data indicating the superior in vitro activity of gemifloxacin against pneumococci, including ciprofloxacin-resistant strains. Although both ciprofloxacin-resistant strains tested had similar quinolone MICs, they differed considerably in their susceptibility to the bactericidal action of these agents. S. pneumoniae 502226 was more readily killed by quinolones than S. pneumoniae 503244 but, as would be expected, both were less susceptible than the ciprofloxacin-sensitive strain. Of the quinolones tested, trovafloxacin showed disproportionally poor activity against the ciprofloxacin-resistant strains even though potent activity was present against the ciprofloxacin-sensitive strain. These data highlight the importance of assessing quinolone bactericidal activity in addition to the MIC when evaluating new members of this antimicrobial class.
Adenosine tips the pathogenic Th1 and Th17 responses in experimental autoimmune uveitis (EAU) (2020)

Abstract Various pathological conditions are accompanied by ATP release from the intracellular to the extracellular compartment, where it degrades into adenosine and modulates immune responses. Previous studies concluded that both ATP and its degradation product adenosine are important immune-regulatory molecules; ATP acted as a danger signal that promotes immune responses, but adenosine’s effect was inhibitory. In this study, we show that adenosine plays an important role in balancing Th1 and Th17 pathogenic T cell responses in autoimmune disease. While its effect on Th1 responses is inhibitory, its effect on Th17 responses is enhancing, thereby impacting the balance between Th1 and Th17 responses. Mechanistic studies showed that this effect is mediated via several immune cells, among which γδ T cell activation and dendritic cell differentiation are prominent; adenosine and γδ-mediated immunoregulation synergistically impact each other’s effect. Adenosine augments the activation of γδ T cells, which is an important promoter for Th17 responses and has a strong effect on DC differentiation tipping the balance from generation of DCs that stimulate Th1 responses to those that stimulate Th17 responses. The knowledge acquired in this study should improve our understanding of the immune-regulatory effect of extracellular ATP-adenosine metabolism and improve treatment for autoimmune diseases caused by both Th1 and Th17-type pathogenic T cells.
Effect of donor‐specific blood transfusions on allotransplanted teeth in a monkey model: Histoquantification of periodontal healing (2021)

Donor-specific blood transfusion did not reduce ankylosis in tooth allografts. The healing of mandibular incisor tooth allografts was improved, but not that of maxillary incisors. Donor-specific antibodies showed no effect on the survival of allograft PDL.
Multiple valued current mode logic circuits (2017)

The circuits having more than two logic levels called as Multiple valued circuits have the potential of reducing area by reducing the on chip interconnection. Despite considerable effort, designing a system for processing a multiple valued signal is still a complicated task. Multiple valued circuits can be realized in voltage or current mode. Due to limited power supply, higher radix valued system is not feasible to design using voltage mode configuration. On the other hand, current mode circuits have the capability of scaling, copying, inverting using basic current mirror structure. The non self restoring nature and higher static power dissipation is the major problem in multiple valued current mode circuits. Self restoration circuits need to be developed for correct detectable output. In this study, Quaternary combinational circuits such as Multiplexer and Full adder are proposed and discussed. Further, Quaternary sequential circuits such as D Flip-Flop, Modulo-16 counter and arbitrary selected state diagram are presented here. Finally, 1-digit quaternary full adder is compared with its equivalent 2-bit binary parallel adder in terms of various VLSI design criteria such as transistor count and average power consumption.
Targeted deletion of Nm23/nucleoside diphosphate kinase A and B reveals their requirement for definitive erythropoiesis in the mouse embryo (2009)

The ubiquitously expressed nucleoside diphosphate kinases (Nm23/NDPK/Awd) are a large family of multifunctional enzymes implicated in nucleic acid metabolism and in normal and abnormal development. Here, we describe the generation and characterization of NDPK A- and B-deficient (Nme1(-/-)/Nme2(-/-)) mice in which >95% of the enzyme activity is eliminated. These mice are undersized, die perinatally, and exhibit a spectrum of hematological phenotypes including severe anemia, impaired maturation of erythrocytes, and abnormal hematopoiesis in the liver and bone marrow. Flow cytometric analysis of developing Nme1(-/-)/Nme2(-/-) erythroid cells indicated that the major iron transport receptor molecule TfR1 is attenuated concomitant with a reduction of intracellular iron, suggesting that TfR1 is a downstream target of NDPKs and that reduced iron in Nme1(-/-)/Nme2(-/-) erythroblasts is inhibiting their development. We conclude that Nm23/NDPKs play critical roles in definitive erythroid development. Our novel mouse model also links erythropoiesis and nucleotide metabolism.
HeartMate-II Left Ventricular Assist Device Infections Resulting from Gastrointestinal-Tract Fistulas (2012)

For detecting the fistulas, full upper-GI endoscopy and colonoscopy were superior to other types of diagnostic imaging studies.
Explosive compaction of Magnequench Nd–Fe–B magnetic powders (1996)

Magnequench NdFeB powders having high and low rare earth contents were explosively compacted to obtain cylindrical magnets. The magnetic properties were found to be isotropic and were superior to conventionally consolidated isotropic magnets. The (BH)max was 14.7 MGOe and the remanence was 8.7 kG for the explosively compacted magnet with lower rare earth content. X-ray diffraction patterns confirm the explosively compacted magnet to be crystalline and the predominant phase to be the 2-14-1 phase. Transmission electron microscopy examination showed a microstructure to consist of 20–25 nm size equiaxed grains consistent with the magnetic measurements.
Coupled-Ring-Resonator-Mirror-Based Heterogeneous III–V Silicon Tunable Laser (2015)

We show theoretical and experimental results from a tunable laser, with its center wavelength in the C-band, designed using coupled-ring resonator mirrors. The effective cavity length enhancement and negative optical feedback obtained from the resonators helps to narrow the laser linewidth in a small form factor. We report a linewidth of 160 kHz and a side-mode suppression ratio of > 40 dB over the full tuning range.
A five‐year retrospective follow‐up study of tapered hydrophilic implants placed with or without GBR procedures (2020)

Background: Preserving the peri-implant bone level is key for the longevity of an implant-supported prosthesis. Experimental studies have shown tapering to improve primary implant stability, especially in soft bone densities. In cases with NO-optimal bone conditions, guided bone regeneration (GBR) procedures may be applied which might challenge the long-term peri-implant bone preservation. Aim/Hypothesis: The aim of the present study was to retrospectively evaluate the survival rate and factors affecting marginal bone levels around tapered implants with a hydrophilic surface after 5 years in function when placed with or without GBR procedures. Materials and Methods: The study group consisted of 50 consecutive patients (18 male/ 33 female, mean age 56.2 years) previously treated with 101 dental implants (Neoss ProActive Tapered implants). Prosthetic solutions included single crowns, partial and full arch reconstructions, allowing both one- and two-stage surgical procedures with either delayed or immediate loading. Patients were scheduled for a six-month and then annually check-ups with clinical and radiographic examination during five years according to the clinic's regular treatment protocol. Subgroup analysis was performed for patients receiving implants with or without GBR procedures, 66 and 35 implants respectively. Marginal bone levels were measured from peri-apical radiographs taken at time of surgery and annual check-ups. Patient-, procedure-, and implant related factors was statistically analysed to evaluate their effect on marginal bone remodeling. Results: No implant failure occurred during the five-year follow-up, resulting in an overall cumulative survival rate (CSR) of 100% following five years of function. The total marginal bone loss measured 0.5 ± 0.5 mm from insertion to 1-year and 0.7 ± 0.7 mm from insertion to 5 years. Between 1 year and 5 years, 0.1 ± 0.5 mm marginal bone loss was recorded. No implant showed more than 3.1 mm bone loss after 5 years. Implant diameter was found to affect bone remodelling, with wide implants losing less bone than narrow implants. No significant differences or correlations were seen for GBR, age, gender, smoking, jaw, implant position, biotype, bone quantity, bone quality, implant length, indication, and surgical/loading protocol. Conclusions and Clinical Implications: The use of Neoss ProActive Tapered implants for prosthetic rehabilitation of consecutive patients resulted in predictable clinical and radiographic outcomes after five years of loading with no differences between augmented and NO-augmented sites. Keywords: Tapered implants, Guided bone regeneration, Clinical study, Long-term follow-up, Bone remodeling
Educating Leaders: Leadership and Entrepreneurial Attributes Development (LEAD) Program at Swinburne University of Technology (2004)

This paper reports on the rationale for and the student experience of the Swinburne University Leadership and Entrepreneurial Attributes Development (LEAD) program. This program offers Research Higher Degree students who have been identified as having high potential for leadership the opportunity to develop leadership and entrepreneurial skills. LEAD comprises two streams of development: leadership and entrepreneurship. The leadership stream of the program aims to expose students to the concepts of teamwork, communication and project leadership. This will enable students to lead Research and Development programs in their professional careers. In addition, it enhances the PhD experience by providing a program that develops networks among students from a broad range of disciplines. These networks will survive beyond the program and serve students throughout their subsequent diverse careers.
Correlation between gain and buildup-time fluctuations in ultrafast avalanche photodiodes and its effect on receiver sensitivity (2005)

The joint statistics of the random gain and random buildup time in ultrafast avalanche photodiodes is determined for the first time. It is shown that the strong correlation present adversely affects intersymbol-interference noise and receiver sensitivity at high transmission rates well beyond previously-known limits.
On finding an optimal TCAM encoding scheme for packet classification (2013)

Hardware-based packet classification has become an essential component in many networking devices. It often relies on TCAMs (ternary content-addressable memories), which need to compare the packet header against a set of rules. But efficiently encoding these rules is not an easy task. In particular, the most complicated rules are range rules, which usually require multiple TCAM entries to encode them. However, little is known on the optimal encoding of such non-trivial rules. In this work, we take steps towards finding an optimal encoding scheme for every possible range rule. We first present an optimal encoding for all possible generalized extremal rules. Such rules represent 89% of all non-trivial rules in a typical real-life classification database. We also suggest a new method of simply calculating the optimal expansion of an extremal range, and present a closed-form formula of the average optimal expansion over all extremal ranges. Next, we present new bounds on the worst-case expansion of general classification rules, both in one-dimensional and two-dimensional ranges. Last, we introduce a new TCAM architecture that can leverage these results by providing a guaranteed expansion on the tough rules, while dealing with simpler rules using a regular TCAM. We conclude by verifying our theoretical results in experiments with synthetic and real-life classification databases.
Intelligent Nanomaterials for Wearable and Stretchable Strain Sensor Applications: The Science behind Diverse Mechanisms, Fabrication Methods, and Real-Time Healthcare (2022)

It has become a scientific obligation to unveil the underlying mechanisms and the fabrication methods behind wearable/stretchable strain sensors based on intelligent nanomaterials in order to explore their possible potential in the field of biomedical and healthcare applications. This report is based on an extensive literature survey of fabrication of stretchable strain sensors (SSS) based on nanomaterials in the fields of healthcare, sports, and entertainment. Although the evolution of wearable strain sensors (WSS) is rapidly progressing, it is still at a prototype phase and various challenges need to be addressed in the future in special regard to their fabrication protocols. The biocalamity of COVID-19 has brought a drastic change in humans' lifestyles and has negatively affected nations in all capacities. Social distancing has become a mandatory rule to practice in common places where humans interact with each other as a basic need. As social distancing cannot be ruled out as a measure to stop the spread of COVID-19 virus, wearable sensors could play a significant role in technologically impacting people's consciousness. This review article meticulously describes the role of wearable and strain sensors in achieving such objectives.
Relationship between hydraulic properties and material features in a heterogeneous vadose zone of a vulnerable limestone aquifer (2021)

Abstract Limestone aquifers constitute important drinking water resources but are vulnerable to groundwater contaminations. They are also known to be often heterogeneous. However, the hydraulic properties of their entire vadose zone and the relationship of these hydraulic properties with their mineralogical and geochemical characteristics remain rarely studied. The hydraulic properties of soft (soil, powdery limestone, and calcareous sand) and hard (limestone rock) materials sampled throughout the entire vadose zone profile of the Beauce limestone aquifer (France) were determined with the multistep outflow method applied using a triaxial system. Physical, mineralogical, and geochemical analysis brought valuable information about factors contributing to the heterogeneity of the hydraulic properties and helped understanding water flow pathways within the vadose zone. The hydraulic properties of the soft materials were strongly related to their physical properties but also to the proportion and the nature of clay minerals. The massive rock presented a few thin microfissures where calcite was replaced by phyllosilicates, thus increasing its water retention capacity. The low hydraulic conductivity of the massive rock could explain the occurrence of perched water tables in the vadose zone. The weathered rock displayed fissures and vugs and was also characterized by the presence of phyllosilicates. The development of a secondary porosity and footprints of water–rock interactions and mass transfers highlighted the transformation of the limestone rock into a more permeable material. This study also pointed out the need to characterize the impact of natural fractures observed at the core scale on the preferential water flow at the field scale.
Computing and Visualizing Reachable Volumes for Maneuvering Satellites (2011)

Detecting and predicting maneuvering satellites is an important problem for Space Situational Awareness. The spatial envelope of all possible locations within reach of such a maneuvering satellite is known as the Reachable Volume (RV). As soon as custody of a satellite is lost, calculating the RV and its subsequent time evolution is a critical component in the rapid recovery of the satellite. In this paper, we present a Monte Carlo approach to computing the RV for a given object. Essentially, our approach samples all possible trajectories by randomizing thrust-vectors, thrust magnitudes and time of burn. At any given instance, the distribution of the &amp;quot;point-cloud &amp;quot; of the virtual particles defines the RV. For short orbital time-scales, the temporal evolution of the point-cloud can result in complex, multi-reentrant manifolds. Visualization plays an important role in gaining insight and understanding into this complex and evolving manifold. In the second part of this paper, we focus on how to effectively visualize the large number of virtual trajectories and the computed RV. We present a real-time out-of-core rendering technique for visualizing the large number of virtual trajectories. We also examine different techniques for visualizing the computed volume of probability density distribution, including volume slicing, convex hull and isosurfacing. We compare and contrast these techniques in terms of computational cost and visualization effectiveness, and describe the main implementation issues encountered during our development process. Finally, we will present some of the results from our end-to-end system for computing and visualizing RVs using examples of maneuvering satellites.
Reliability of diagnostic coding in intensive care patients (2008)

In a multicenter database designed primarily for epidemiological and cohort studies in ICU patients, the coding of medical diagnoses varied between different observers. This could limit the interpretation and validity of research and epidemiological programs using diagnoses as inclusion criteria.
Oxidation Catalysis by Oxide-Supported Au Nanostructures: The Role of Supports and the Effect of External Conditions (2006)

Oxide-supported Au nanostructures are promising low-temperature oxidation catalysts. It is generally observed that Au supported on reducible oxides is more active than Au supported on irreducible oxides. Recent studies also suggest that cationic Au(delta+) is responsible for the unique Au/oxide catalytic activity, contrary to the conventional perception that oxide supports donate electronic charge to Au. We have utilized density functional calculations and ab initio thermodynamic studies to investigate the oxidation state of Au nanostructures deposited on reducible and irreducible supports. We find that there are fundamental differences in the electronic structure of Au deposited on the different oxides. We propose a simple model, grounded in the first principles calculations, which can explain the oxide-specific catalytic activity of Au nanostructures and which can account for the presence and the role of cationic Au(delta+).
3D Printing as an Alternative to Casting, Forging and Machining Technologies? (2015)

3D printing technology has recently extended to metallic materials and allows now to produce 3D models directly from metallic powders. There are several methods of 3D metal printing, such as Selective Laser Sintering (SLS), Direct Metal Laser Sintering (DMLS), Electron beam melting (EBM) or Selective laser melting (SLM). Compared to conventional technologies of casting, forging and machining, these methods offer many advantages. The most important is shape variety allowing preparation of very complicated shapes and designs, which would be impossible to reach by classical techniques. Moreover, there is practically no material loss, since the remaining powder can be recycled and reused in other manufacturing processes. That is one of important cost savings. However, for now, the metal 3D printing is unable to compete the price of large-lot production. In present paper, it is demonstrated that by the SLM technology it is possible to achieve comparable material properties of stainless steel AISI 316L as by conventional technologies and therefore, this method offers a suitable alternative.
Pseudo-Occlusion of the Internal Carotid Artery Predicts Poor Outcome After Reperfusion Therapy (2018)

Four dimensional-computed tomography angiography is a useful noninvasive technique to identify ICA-PO. Patients with ICA-PO are prone to undergo poor outcome from reperfusion therapy, especially when reperfusion is not achieved.