gebhart/patrepeval huggingface dataset:
[Think of varicella pneumopathy in an immunocompromised patient]. (1997)

L'observation Monsieur P., âge de 68 ans, ancien fumeur, avec tabagisme interrompu a l'âge de 53 ans, est suivi et traite depuis 1989 pour un lymphome malin recemment evolutif sur un mode lympho-plasmocytaire. En aout 1996, la decouverte d'une infiltration lombo-aortique englobant le pedicule renal droit motive une nouvelle cure de chimiotherapie. Monsieur P. est hospitalise en septembre 1996 dans un service de pneumologie pour prise en charge d'une pneumopathie atypique. Il presente une hyperthermie a 38,6°, une dyspnee de repos, des levres cyanosees. L'auscultation pulmonaire est normale. Des lesions prurigineuses diffuses (non metameriques), vesiculo-crouteuses bordees d'un lisere rouge, sont decouvertes essentiellement sur le tronc et les membres. Cette eruption est apparue trois jours auparavant. Les examens complementaires permettent de decouvrir des opacites thoraciques micronodulaires bilaterales predominantes a droite, une lymphopenie (400 lymphocytes par mm3), une VS a 110 mm a la 1re heure et une alcalose respiratoire moderee. La recherche d'agents microbiens dans les prelevements sanguins et endobronchiques est negative. Le lavage broncho-alveolaire ramene un liquide avec une predominance de polynucleaires neutrophiles (85 %), mais aucun agent pathogene bacterien ou parasitaire n'est isole. Une biopsie des lesions cutanees est effectuee, et apres mise en culture sur cellules fibroblastiques (MRC5), la presence de virus varicelle-zona (VZV) est detectee sur les cellules infectees. Le traitement a comporte, outre une oxygenotherapie par voie nasale, du Zovirax® par voie intraveineuse, 10 mg/kg toutes les 8 heures, pendant 7 a 10 jours, ainsi que des soins antiseptiques des lesions cutanees et des antipyretiques. L'evolution a ete favorable.
Evaluating pediatric and adult simulated fluids solubility: Abraham solvation parameters and multivariate analysis (2021)

Statistical models based on Abraham solvation parameters were applied mostly to better understand drug solubility differences in adult and pediatric biorelevant media.
Fouling Behaviour of Porous Metals (2014)

Applications for porous materials range from structural materials to filters and acoustic absorbers. In many of these applications, e.g. silencers or air filters, the porous material is exposed to dirt. Fouling of filter materials and acoustic absorbers can change their characteristics by blocking pores, changing the pore morphology and decreasing the porosity. As parameters like trade efficiency and flow resistivity, that are important for the functionality of filters and acoustic absorbers, depend on the porosity and pore morphology, the fouling behaviour of porous materials is of major interest. In this study porous metals with different pore morphologies and porosities are investigated, such as microperforated panels, sintered fiber felts, metal foams and nanoporous superalloy membranes. The materials are mounted on a roof rack and polluted for a period of six month. The samples are periodically examined for changes in geometrical characteristics and flow resistivity. The materials are characterized using three dimensional CT-images as well as two dimensional microscopy images. Finally the correlation of geometrical characteristics, fouling behaviour and flow resistivity is outlined.
Effect of Radiation Therapy on Survival in Hodgkin’s Lymphoma: A SEER Data Analysis (2017)

Radiation therapy improved survival in patients with all stages of HL. Demographic and disease factors associated with worse survival in this study may be related to particular patterns of care and warrant additional study.
Etiological involvement of oncogenic human papillomavirus in tonsillar squamous cell carcinomas lacking retinoblastoma cell cycle control. (1998)

Two hundred eight primary squamous cell carcinomas of the head and neck have been analyzed with respect to the presence of the retinoblastoma tumor suppressor protein, pRb. Of these, 23 tumors (11%) that preferentially localized to the tonsils revealed complete absence or dramatic reduction in the amount of pRb. Other cell cycle components, cyclin D1 and p16INK4A, which are intimately related to pRb through an autoregulatory loop, were also dramatically decreased or overexpressed, respectively, in these pRb-defective tumors. On the other hand, the majority of the pRb-defective tumors contained the wild-type p53 gene. No evidence was found for genetic defects at the Rb locus in these tumors. Very significantly, in 11 of 12 pRb-defective tonsillar tumors, but in none of 9 pRb-positive tonsillar tumors (P < 10[-7]), DNA of oncogenic human papillomavirus types was identified, providing a strong indication for a human papillomavirus-associated etiology of these tumors and suggesting the functional inactivation of the pRb protein by the viral E7 gene product. In comparison to all head and neck squamous cell carcinomas studied, the pRb-defective tonsillar tumors were in general more poorly differentiated (P = 0.0059), and they were all metastatic at the time of resection. Of particular clinical interest, despite these adverse histopathological factors, the clinical outcome for these patients was relatively favorable, strongly implying that the pRb-defective tumors responded uniformly well toward postoperative radiation therapy.
InCar - Advanced Door Design (2012)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;The ThyssenKrupp InCar Project is a comprehensive R&amp;amp;D development that gives automotive manufacturers modular solution kits for body, chassis and powertrain applications. The solution kits developed within this project offer weight reduction, cost savings or improved functionality. This paper will focus on the two front door solutions developed within the InCar project. The first door solution, called the Lightweight Door, achieved a 13% weight reduction. This door features a 4-piece tailored blank inner panel and a sandwich material outer panel. The second door solution, called the Advanced Door, is a completely new and innovative door architecture that uses a 2-piece tailored blank mid panel and ultra thin Dual Phase 500 outer panel to achieve an 11% weight reduction. Prototypes were manufactured and tested for both door solutions. This paper will provide a detailed description of everything related to the development of these door solutions, including manufacturing and assembly processes, performance, materials, and cost estimation.&lt;/div&gt;&lt;/div&gt;
Efficient multiple gene knockout in Colletotrichum higginsianum via CRISPR/C as9 ribonucleoprotein and URA3 ‐based marker recycling (2023)

Colletotrichum higginsianum is a hemibiotrophic pathogen that causes anthracnose disease on crucifer hosts, including Arabidopsis thaliana. Despite the availability of genomic and transcriptomic information and the ability to transform both organisms, identifying C. higginsianum genes involved in virulence has been challenging due to recalcitrance to gene targeting and redundancy of virulence factors. To overcome these obstacles, we developed an efficient method for multiple gene disruption in C. higginsianum by combining CRISPR/Cas9 and a URA3-based marker recycling system. Our method significantly increased the efficiency of gene knockout via homologous recombination by introducing genomic DNA double-strand breaks. We demonstrated the applicability of the URA3-based marker recycling system for multiple gene targeting in the same strain. Using our technology, we successfully targeted two melanin biosynthesis genes, SCD1 and PKS1, which resulted in deficiency in melanization and loss of pathogenicity in the mutants. Our findings demonstrate the effectiveness of our methods in analysing virulence factors in C. higginsianum, thus accelerating research on plant-fungus interactions.
Curve and Surface Modeling with Uncertainties Using Dual Kriging (1999)

This paper presents a new technique based on dual Kriging interpolation for modeling curves and surfaces in the presence of uncertainties in data points. Uncertainties result from measurement errors; therefore, a direct application of this method is found in curve/surface modeling using discrete sets of digitized points. It focuses on a common problem in geometric modeling, the trade-off between curve/surface smoothness and the approximation errors. The Kriging model filters the noise in the data while controlling the deviation locally at each point. However, the classical least-squares technique minimizes the average deviation, hence allowing only a global control of the model. The presented method generates smoother and more accurate representation of the actual curve or surface. It has potential applications in reverse engineering, NC machining, computer-aided inspection and tolerance analysis and verification. Examples of a computer mouse and a portion of the hood of a scaled-down car are presented for illustration.
Implementation and validation of an ultrasonic tissue characterization technique for quantitative assessment of normal‐tissue toxicity in radiation therapy (2009)

The goal of this study was to implement and validate a noninvasive, quantitative ultrasonic technique for accurate and reproducible measurement of normal-tissue toxicity in radiation therapy. The authors adapted an existing ultrasonic tissue characterization (UTC) technique that used a calibrated 1D spectrum based on region-of-interest analysis. They modified the calibration procedure by using a reference phantom instead of a planar reflector. This UTC method utilized ultrasonic radiofrequency echo signals to generate spectral parameters related to the physical properties (e.g., size, shape, and relative acoustic impedance) of tissue microstructures. Three spectral parameters were investigated for quantification of normal-tissue injury: Spectral slope, intercept, and midband fit. They conducted a tissue-mimicking phantom study to verify the reproducibility of UTC measurements and initiated a clinical study of radiation-induced breast-tissue toxicity. Spectral parameter values from measurements on two phantoms were reproducible within 1% of each other. Eleven postradiation breast-cancer patients were studied and significant differences between the irradiated and untreated (contralateral) breasts were observed for spectral intercept (p = 0.003) and midband fit (p < 0.001) but not for slope (p = 0.14). In comparison to the untreated breast, the average difference in the spectral intercept was 2.99 +/- 0.75 dB and the average difference in the midband fit was 3.99 +/- 0.65 dB. The preliminary clinical study demonstrated the feasibility of using the quantitative ultrasonic method to evaluate normal-tissue toxicity in radiation therapy.
Constrained Labeling for Weakly Supervised Learning (2021)

Curation of large fully supervised datasets has become one of the major roadblocks for machine learning. Weak supervision provides an alternative to supervised learning by training with cheap, noisy, and possibly correlated labeling functions from varying sources. The key challenge in weakly supervised learning is combining the different weak supervision signals while navigating misleading correlations in their errors. In this paper, we propose a simple data-free approach for combining weak supervision signals by defining a constrained space for the possible labels of the weak signals and training with a random labeling within this constrained space. Our method is efficient and stable, converging after a few iterations of gradient descent. We prove theoretical conditions under which the worst-case error of the randomized label decreases with the rank of the linear constraints. We show experimentally that our method outperforms other weak supervision methods on various text- and image-classification tasks.
‘Effective governance’ through complexity thinking and management science (2001)

Abstract Recently, many claims have been made that new models of organization are emerging in the public and voluntary sector. These are partnerships, alliances, fora and consortia, to mention but a few, and they encompass both active participation of their members and/or users and the governance of their activities. The patterns of governance emerging, in my view, offer a different set of problems for the management sciences. Policy, strategy and accountability are now being developed within a complex network of different organizations drawn from the public and voluntary sector, aiming to govern or regulate the public sphere. This paper will explore how management scientists can address these patterns of governance. It will be argued that, if governance has supplanted management as an issue for the management sciences in this context, a new or different language is needed to ‘re‐present’ the problems. In particular, it will be shown that management science can be employed to find a clear balance between good governance and effective management. This paper will also propose a framework that may be used to help the new organizational arrangements achieve effective governance. Copyright © 2001 John Wiley &amp; Sons, Ltd.
Peculiarities of Rickettsia prowazekii in the cell culture as revealed by cryoultramicrotomy. (1986)

Ultrastructure of Rickettsia prowazekii has been followed in L-929 cells 4 days post-infection (p.i.) by cryoultramicrotomy. Groups of rickettsiae were present in the cytoplasm outside of vacuoles forming microcolonies. The size of rickettsiae amounted to 400 X 700 nm, the average thickness of the cell wall was 5 nm, that of periplasmic space and cytoplasmic membrane 14 and 6 nm, respectively. Within intracytoplasmic colonies the rickettsiae were tightly packed and their cell walls were closely adjacent to each other. No halo or capsule-like coating around them was detected. No ultrastructural details were observed in the light translucent spaces between cells. Marginal rickettsiae of the microcolonies were often in close contact with the host cell mitochondria.
Wireless Distributed Measurement System by Using Mobile Devices (2005)

The innovative architecture of distributed measurement systems (DMS) is proposed in order to increase the adaptability characteristic to the new necessity of the industrial applications. This architecture is based on (i) the wireless technology to realize the communication structure and (ii) the personal digital assistant to manage and control the measurement instrumentations. The wireless protocol IEEE 802.11 is used to realize the local area network. The aspects concerning both the software and the hardware to realize the wireless DMS are discussed. In order to evidence innovative features, two applicative examples are shown and discussed.
Syntheses of 2,3,6-trideoxy-3-amino- and 2,3,6-trideoxy-3-nitrohexoses (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSyntheses of 2,3,6-trideoxy-3-amino- and 2,3,6-trideoxy-3-nitrohexosesFrank M. Hauser and Suzanne R. EllenbergerCite this: Chem. Rev. 1986, 86, 1, 35–67Publication Date (Print):February 1, 1986Publication History Published online1 May 2002Published inissue 1 February 1986https://pubs.acs.org/doi/10.1021/cr00071a003https://doi.org/10.1021/cr00071a003research-articleACS PublicationsRequest reuse permissionsArticle Views525Altmetric-Citations121LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Key Techniques in Intelligent Predictive Maintenance (IPdM) – A Framework of Intelligent Faults Diagnosis and Prognosis System (IFDaPS) (2014)

Intelligent predictive maintenance (IPdM) is a maintenance strategy that makes maintenance decisions automatically and dynamically based on Artificial Intelligence and Data mining techniques through condition monitoring of machines, equipment and production processes. IPdM system consists of the following main modules: sensor and data acquisition, signal and data processing, feature extractions, maintenance decision-making, key performance indicators, maintenance scheduling optimization and feedback control and compensation. Among them, the most important part of IPdM is maintenance decision-making, which includes diagnostics and prognostics. This paper proposes a framework of intelligent faults diagnosis and prognosis system ( IFDaPS ) and discuss some key technologies for implement IPdM policy in manufacturing and industries. A case study focus on the vibration signals collected from the sensors mounted on a pressure blower for critical components monitoring. We decompose the pre-processed signals into several signals using Wavelet Packet Decomposition (WPD), and then the signals are transformed to frequency domain using Fast Fourier Transform (FFT). The features extracted from frequency domain are used to train Artificial Neural Network (ANN). Trained ANN model is able to identify the fault of the components and predict its Remaining Useful Life (RUL). The case study demonstrates how to implement the proposed framework and intelligent technologies for IPdM and the result indicates its higher efficiency and effectiveness comparing to traditional methods.
Ab initio calculations of electric field effects on the g-tensor of a nitroxide radical (2001)

The effects of applied electric fields on the magnetic parameters of a nitroxide spin label have been calculated using an intermediate level of Rayleigh–Schrödinger perturbation theory based on unrestricted Hartree–Fock ab initio calculations. The theory is tested for selected simple model organic radicals and gives electronic g-tensors that compare well with previous calculations and experimental values. The method is then applied to calculate effects of a local electrostatic field on the larger nitroxide radical, 2,2,5,5-tetramethyl-3,4-dehydro pyrrolidine-1-oxyl (TMDP) using a finite field approach. The method slightly underestimates the gx and gy of TMDP, but the predicted shifts in these quantities with field are in excellent agreement with recent experimental observations using high-frequency (220 GHz) electron paramagnetic resonance. Results are expressed in terms of the phenomenological formalism given earlier by Mims to characterize linear electric field effects in metal centers.
Hypertension: β testing (2003)

A new study demonstrates that angiotensin-induced hypertension results in a marked decrease in expression of the beta subunit of the BK channel, suggesting a role for this critical subunit in the regulation of vascular tone.
Simulation and Sensitivity Analysis and Cross-Validation, Demonstrating the Utility of Genteract GxE Discovery methods (2020)

Abstract Gene-environment interactions are at the heart of why many complex traits are not fully heritable, and why prediction of disease incidence and individual response to environmental changes based on genetics has been underwhelming in utility. Understanding these interactions is the primary limiting factor for the application of personalized medicine, but current methods are not well suited for dealing with complex traits that pose both a dimensionality and sparse data problem to unsupervised analysis methods. Genteract has developed a proprietary analytical technique that allows for detection and interpretation of GxEs regarding specific pairs of a single phenotype with a single environmental factor; these methods allow us to develop a platform that can be used to predict how individuals will respond to changes in their environment based on their genetics. To validate the methods we performed two types of testing: cross-validation against a dataset of clinical study results, and application of the methods in a simulated dataset. These tests enable a greater understanding of the methods’ utility, statistical power and predictive capabilities.
Mass spectrometric analysis of cyclofenil and its metabolites in human urine (2002)

Using gas chromatography/electron impact-mass spectrometry (GC/EI-MS) and high performance liquid chromatography with atmospheric pressure chemical ionization tandem mass spectrometry (HPLC/APCI-MS/MS), the structures of cyclofenil metabolites in human urine have been assigned. The hydroxyl metabolites liberated from the glucuronide conjugates after acid hydrolysis were characterized as the trimethylsilyl (O-TMS) derivatives using GC/MS. The conjugate glucuronide forms were detected without hydrolysis by HPLC/MS. Cyclofenil was not observed in urine. Tentative structures for the two metabolites are proposed.
An outboard processor for high performance implementation of transport layer protocols (2002)

The high throughputs promised by emerging network technologies are often difficult to achieve application-to-application because of host transport protocol bottlenecks. The authors describe an experimental prototype implementation of an outboard protocol processor which eliminates these bottlenecks by performing transport layer functions in dedicated hardware. The architecture consists of separate transmit and receive CPUs, each with checksum and direct memory access circuits. Measurements made using an implementation of the TCP protocol indicate that this architecture can support end-to-end throughputs in excess of 11000 packets/s between UNIX hosts. One of the aims is to use this processor to determine the most appropriate techniques for transport of data on high speed metropolitan area networks.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Transfusion premedication practices among pediatric health care practitioners in Canada: results of a national survey (2016)

Premedication practices are variable in Canadian pediatric academic hospitals. Evidence-based premedication clinical practice guidelines and SOS could be explored as a way to standardize practices. There were perceived educational and institutional barriers to practice change.