gebhart/patrepeval huggingface dataset:
[Noninvasive carotid plaque characterization by black blood MRI]. (2005)

Management of atherosclerotic carotid arteries requires both plaque characterization and determination of the degree of stenosis, especially when carotid stenting (CAS) is being considered for severe carotid stenosis. Recent studies have demonstrated that high-resolution MRI can identify plaque components, such as the lipid-rich necrotic core, intraplaque hemorrhage, fibrous tissue, and the calcification present in human carotid atherosclerosis. The purpose of this study was to assess the feasibility of black blood MRI (BB-MRI) for accurately identifying the plaque components in vivo. Twenty-six consecutive patients scheduled for carotid endarterectomy (CEA) underwent a BB-MRI examination within 2 weeks before the surgical procedure using a 1.5-T Philips scanner with a protocol that generated 2 contrast weightings (T1 and T2). The MR images were acquired using cardiac gating to minimize motion artifact and fat suppression to reduce MR signals from subcutaneous fatty tissue. The plaque evaluations obtained by BB-MRI were compared with the intra-operative video recordings, the excised specimens, and the histological sections. With BB-MRI, the combination of the signal intensities in the T1- and T2-weighted images for each component (lipid deposits, intra-plaque hemorrhage, fibrous plaque, and calcification) showed findings that corresponded with the excised specimens. Complex morphological features could also be assessed by BB-MRI. BB-MRI is a useful method for noninvasively imaging and characterizing atherosclerotic carotid arteries. This MRI technique can provide valuable information that can be used to decide whether to perform a CEA or a CAS in patients with severe carotid stenosis. Furthermore, BB-MRI appears to be a useful tool for the investigation of the pathogenesis and natural history of carotid atherosclerosis.
IDoser: Improving individualized dosing policies with clinical practice and machine learning (2023)

Abstract Background Finding the correct drug dose for a specific condition is a key step in many treatments, and failing to do so can lead to deleterious consequences to patient health. Clinical protocols are derived from drug development phase prospective trials. While carefully designed, these often do not include all potential patients, comorbidities or clinical outcomes, ultimately leading to sub-optimal dosing policies. Observational datasets provide real-world information that cannot be substituted with data collected in a controlled environment. Several published methodologies have applied observational datasets for the development of clinical protocols, however these are only applicable whenever these datasets are varied and complete. Often, clinical observational datasets do not comply with these requirements. Computational methods can and should exploit field knowledge to address weaknesses associated with clinical observational data. Methods This paper proposes IDoser, a core dosing model that links drug dose to relevant covariates via a set of coefficients, and includes a loss function to codify needed assumptions and requirements. Coordinate descent is used to obtain a fitted model with minimal loss. The loss function is also used to measure performance when validating the model with unseen data. Our proposal is validated using the case of follicle stimulating hormone (FSH) dosing for controlled ovarian stimulation (COS). Results The proposed Individualized Doser (IDoser) achieved significant improvements when loss values were compared to observed clinical practice and a selected literature benchmark and during the validation phase. Conclusions This methodology constitutes a simple but effective method to bridge the gap between current clinical dosing policies and gold policies based on the true underlying and often unknown dose-response functions.
Expression of key hypoxia sensing prolyl‐hydroxylases PHD1, ‐2 and ‐3 in pancreaticobiliary cancer (2010)

Our results provide the first clinical evidence that PHD1, PHD2 and PHD3 may be involved in pancreaticobiliary tumorigenesis.
Cosmological Parameters from Galaxy Clustering in the SDSS (2006)

We present estimates of cosmological parameters from the application of the Karhunen-Love transform to the analysis of the 3D power spectrum of density fluctuations using Sloan Digital Sky Survey galaxy redshifts. We use m h and f b b m to describe the shape of the power spectrum, L 8g for the (linearly extrapolated) normalization, and to parametrize linear theory redshift space distortions. On scales k 0 16hMpc 1 , our maximum likelihood values are
Microwave-irradiated green synthesis of gold nanoparticles for catalytic and anti-bacterial activity (2017)

Herein, we report a green, microwave irradiated synthesis of gold nanoparticles by using a simple, low cost and ecofriendly technique. The green technique has been developed for the synthesis of gold nanoparticles (AuNPs) from HAuCl4 using papaya leaf extract. The papaya leaf extract served both as a reductant and a stabilizer. The synthesized AuNPs had been characterized by UV-Visible spectrophotometer, Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Zeta potential and Transmission electron microscopy (TEM) techniques. The results indicated that the synthesized nanoparticles were crystalline, stable, well dispersed and spherical in shape and had an average diameter of 15 ± 2 nm. The AuNPs showed excellent catalytic activity for the reduction of p-nitrophenol (4-NP) to p-aminophenol (4-AP) in the presence of NaBH4. The effects of concentration of NaBH4, catalyst dose and temperature on the formation of nanoparticles were studied. The activation energy was found to be 28.15 ± 1.14 kJ/mol. The papaya leaf extract capped AuNPs are highly stable, and have showed effective catalytic activity in the reduction of 4-NP to 4-AP and antimicrobial activity on both gram-positive and gram-negative bacteria.
A time domain model for transient simulation of synchronous machines using phase coordinates (2006)

This paper presents a synchronous machine model for transient system analysis with trapezoidal and Euler methods. The model uses phase coordinates for stator windings coupled with excitation and damper windings. The phase representation allows the integration of synchronous machines parameters in the power system network Y <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">BUS</sub> matrix. Such matrix allows the simultaneous solution of the machines and the network nodal equations in the time domain. Non linear phenomenon such as saturation effects can also be incorporated and require a few additional iterations. Simulation time can be reduced further for large systems by using decoupled resolution and prediction techniques on the machine current
Characterization of alternative plasticizers in poly(vinyl chloride) sheets for blood containers (2015)

This study aimed to optimize the ratio of dioctyl 4‐cyclohexene‐1,2‐dicarboxylate (DOTH) and di‐isononyl‐cyclohexane‐1,2‐dicarboxylate (DINCH ® ) for use as plasticizers in poly(vinyl chloride) (PVC) sheets. We also evaluated the biological safety of DOTH for its potential to be part of a safe PVC‐based blood container. The suppression of hemolysis in mannitol‐adenine‐phosphate / red cell concentrates (MAP/RCC) with DOTH/(DINCH ® ‐PVC) sheets and the elution of plasticizers from the sheets increased with higher DOTH compositions. The properties of the PVC sheet containing DOTH and DINCH ® in the ratio of 25:33 parts against PVC 100 parts as a weight were almost identical to the PVC sheet made of di(2‐ethylhexyl) phthalate. From a subchronic toxicity test, DOTH did not show any adverse effects on all organs, including the testes, epididymis, liver, and kidneys. The no‐observed‐adverse‐effect level was 300 mg/kg body weight/day in a rat. These results suggest that DOTH/DINCH ® (25:33) is a promising candidate for the replacement of di(2‐ethylhexyl) phthalate in blood containers. J. VINYL ADDIT. TECHNOL., 22:520–528, 2016. © 2015 Society of Plastics Engineers
Mechanisms of protein modification during model anti‐viral heat‐treatment bioprocessing of β‐lactoglobulin variant A in the presence of sucrose (2000)

To ensure the safety of plasma and recombinant therapeutic proteins, heat treatment is routinely applied to these biopharmaceuticals as a means of virus inactivation. However, to maintain protein integrity during heat treatment it is necessary to use high concentrations of thermostabilizing excipients, such as sucrose, in order to prevent protein damage. In this study we describe the covalent modifications inferred to a model protein, beta-lactoglobulin A, that occur during typical and extended anti-viral heat treatments. The chemical derivation and mechanisms by which these modifications arise are addressed. Heat treatment initiated hydrolysis of sucrose to glucose and fructose, which in turn were degraded to glyoxal. Glyoxal and the free reducing sugars reacted with free amino groups in beta-lactoglobulin A to yield Maillard glycation adducts and advanced glycation end products (AGEs). The major mechanism for AGE formation was via degradation of glucose-derived Schiff-base adducts. Heat treatment and glycation of beta-lactoglobulin A resulted in thiol-disulphide interchange reactions leading to protein oligomerization. A small population of beta-lactoglobulin A non-disulphide-linked dimers were also observed with increasingly harsh heat treatments. These findings have implications for (i) improvements in the safety and efficacy of heat-treated protein biopharmaceuticals and (ii) our understanding of the mechanisms of protein glycation and AGE adduct formation.
The Impact of Technology on Adolescent Identity Development (2014)

This paper explores how technology use in adolescence facilitates adult identity achievement and presents evidence that technological objects, such as smartphones have become adolescent transitional objects. Early and late adolescents were surveyed about technology use and feelings associated with technology. Among older adolescents, anxiety level was related to smart phone use, such that higher anxiety was associated with greater smart phone use. The feelings and behaviors associated with use of the preferred device are consistent with feelings and behaviors associated with use of a transitional object. In contrast, younger adolescents did not appear to use technology as a transitional object. This difference may be that older adolescents are in an active phase of transition, developmentally, with movement to a university. Understanding how technology is viewed by adolescents provides insight into how technology can be used in critical environments, such as schools and homes, to facilitate a healthy transition to adulthood.
Chimeric Peptides from Californiconus californicus and Heterodontus francisci with Antigen-Binding Capacity: A Conotoxin Scaffold to Create Non-Natural Antibodies (NoNaBodies) (2023)

Research into various proteins capable of blocking metabolic pathways has improved the detection and treatment of multiple pathologies associated with the malfunction and overexpression of different metabolites. However, antigen-binding proteins have limitations. To overcome the disadvantages of the available antigen-binding proteins, the present investigation aims to provide chimeric antigen-binding peptides by binding a complementarity-determining region 3 (CDR3) of variable domains of new antigen receptors (VNARs) with a conotoxin. Six non-natural antibodies (NoNaBodies) were obtained from the complexes of conotoxin cal14.1a with six CDR3s from the VNARs of <i>Heterodontus francisci</i> and two NoNaBodies from the VNARs of other shark species. The peptides cal_P98Y vs. vascular endothelial growth factor 165 (VEGF<sub>165</sub>), cal_T10 vs. transforming growth factor beta (TGF-β), and cal_CV043 vs. carcinoembryonic antigen (CEA) showed in-silico and in vitro recognition capacity. Likewise, cal_P98Y and cal_CV043 demonstrated the capacity to neutralize the antigens for which they were designed.
Vibration resistant high pressure tube fitting (1987)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Leonard J. Kowal, Albert J. Schwarz; Vibration resistant high pressure tube fitting. J. Acoust. Soc. Am. 1 February 1987; 81 (2): 581. https://doi.org/10.1121/1.394848 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAcoustical Society of AmericaThe Journal of the Acoustical Society of America Search Advanced Search |Citation Search
Effect of different TCO interfaces on the performances presented by hydrogenated amorphous silicon p-i-n solar cells (1994)

In this paper we report results concerning the effect of the TCO interface on hydrogenated amorphous silicon (a-Si:H) p-i-n homojunction solar cells. Its correlation with dark current density-voltage (J-V) characteristics and spectral response, before and after white light-soaking degradation, is analysed. From this study, we conclude that the properties and stability of these devices are not only influenced by the a-Si:H film properties, but also by the properties of the transparent conductive electrode and its interface with the a-Si:H layer.
Inhibition of γ-secretase activity synergistically enhances tumour necrosis factor-related apoptosis-inducing ligand induced apoptosis in T-cell acute lymphoblastic leukemia cells via upregulation of death receptor 5 (2016)

T-cell acute lymphoblastic leukemia (T-ALL) is a rare and aggressive hematopoietic malignancy prone to relapse and drug resistance. Half of all T-ALL patients exhibit mutations in Notch1, which leads to aberrant Notch1 associated signaling cascades. Notch1 activation is mediated by the γ-secretase cleavage of the Notch1 receptor into the active intracellular domain of Notch1 (NCID). Clinical trials of γ-secretase small molecule inhibitors (GSIs) as single agents for the treatment of T-ALL have been unsuccessful. The present study demonstrated, using immunofluorescence and western blotting, that blocking γ-secretase activity in T-ALL cells with <i>N</i>-[(3,5-difluorophenyl) acetyl]-L-alanyl-2-phenyl] glycine-1,1-dimethylethyl ester (DAPT) downregulated NCID and upregulated the tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor 5 (DR5). Upregulation of DR5 restored the sensitivity of T-ALL cells to TRAIL. Combination index revealed that the combined treatment of DAPT and TRAIL synergistically enhanced apoptosis compared with treatment with either drug alone. TRAIL combined with the clinically evaluated γ-secretase inhibitor 3-[(1r, 4s)-4-(4-chlorophenylsulfonyl)-4-(2, 5-difluorophenyl) cyclohexyl] propanoic acid (MK-0752) also significantly enhanced TRAIL-induced cell death compared with either drug alone. DAPT/TRAIL apoptotic synergy was dependent on the extrinsic apoptotic pathway and was associated with a decrease in BH3 interacting-domain death agonist and x-linked inhibitor of apoptosis. In conclusion, γ-secretase inhibition represents a potential therapeutic strategy to overcome TRAIL resistance for the treatment of T-ALL.
IBM DB2ユニバーサル・データベース : Windows NT版 速習ガイド (1998)

第１部 入門編（インストール；コントロール・センター；フロントエンド・ツールをインストールしてデータを操作する ほか） 第２部 より高度なデータベース管理（ユーザー、権限および特権；スキーマ；視点（ビュー） ほか） 第３部 先進機能（ＤＢ２のモニター；パフォーマンス；Ｖｉｓｕａｌ Ｅｘｐｌａｉｎの解説 ほか）
Composite construction materials from plant resources: mechanical characterization and statistical approach (2022)

For ecological reasons, the recovery of agricultural waste has become a global necessity. These enormous residues, biodegradable, can be used with different percentages as a reinforcing element in cementitious matrices in building materials. This study deals with the influence of the length and percentage of date palm trunk fibers (DPTF) incorporated into bio-mortars. In order to improve the fiber/matrix cohesion energy, the extracted DPTFs underwent alkaline treatments, by varying the percentage of sodium hydroxide and the immersion time before being used in the preparation of bio-mortar. Compression tests were carried out to evaluation the mechanical properties, namely the ultimate stresses, Young's modulus and displacements. To do this, a design of experiment was carried out using the response surface methodology (RSM) in order to minimize the number of tests. The results obtained shows that the incorporation of DPTFs in the mortar can improve the mechanical behavior of the bio-mortar by 46.6% and 36.3% in the compressive strength and Young’s modulus, respectively.For ecological reasons, the recovery of agricultural waste has become a global necessity. These enormous residues, biodegradable, can be used with different percentages as a reinforcing element in cementitious matrices in building materials. This study deals with the influence of the length and percentage of date palm trunk fibers (DPTF) incorporated into bio-mortars. In order to improve the fiber/matrix cohesion energy, the extracted DPTFs underwent alkaline treatments, by varying the percentage of sodium hydroxide and the immersion time before being used in the preparation of bio-mortar. Compression tests were carried out to evaluation the mechanical properties, namely the ultimate stresses, Young's modulus and displacements. To do this, a design of experiment was carried out using the response surface methodology (RSM) in order to minimize the number of tests. The results obtained shows that the incorporation of DPTFs in the mortar can improve the mechanical behavior of the bio-mortar by 46.6% and 36.3% in the compressive strength and Young’s modulus, respectively.
FormTester: Effective Integration of Model-Based and Manually Specified Test Cases (2015)

Whilst Model Based Testing (MBT) is an improvement over manual test specification, the leap from it to MBT can be hard. Only recently MBT tools for Web applications have emerged that can recover models from existing manually specified test cases. However, there are further requirements for supporting both MBT and manually specified tests. First, we need support for the generation of test initialization procedures. Also, we want to identify areas of the system that are not testable due to defects. We present Form Tester, a new MBT tool addressing these limitations. An evaluation with real Web applications shows that Form Tester helps to reduce the time spent on developing test cases.
BioMEMS and Cellular Biology: Perspectives and Applications (2007)

The ability to culture cells has revolutionized hypothesis testing in basic cell and molecular biology research. It has become a standard methodology in drug screening, toxicology, and clinical assays, and is increasingly used in regenerative medicine. However, the traditional cell culture methodology essentially consisting of the immersion of a large population of cells in a homogeneous fluid medium and on a homogeneous flat substrate has become increasingly limiting both from a fundamental and practical perspective. Microfabrication technologies have enabled researchers to design, with micrometer control, the biochemical composition and topology of the substrate, and the medium composition, as well as the neighboring cell type in the surrounding cellular microenvironment. Additionally, microtechnology is conceptually well-suited for the development of fast, low-cost in vitro systems that allow for high-throughput culturing and analysis of cells under large numbers of conditions. In this interview, Albert Folch explains these limitations, how they can be overcome with soft lithography and microfluidics, and describes some relevant examples of research in his lab and future directions.
WOOD PROPERTIES OF SELECTED LESSER.USED HONDURAN WOOD SPECIES (2005)

This paper examines the physical and mechanical properties of seven selected lesser-used species in Honduras for the purpose of promoting broader species utilization and reducing pressure on highly demanded species in the country. Of the seven species tested, Terminalia amazonia consistently yielded favourable results for most mechanical property tests. It appears that this species has high potential for further development and market research for many applications, both structural and non-structural. Ilex tectonica, Calophyllum brasiliense and Terminalia amazonia were then compared against book values for Honduran mahogany using Student's t-tests. All were found to be fairly comparable for modulus of rupture, modulus of elasticity and maximum crushing strength.
Docetaxel as neoadjuvant chemotherapy in patients with stage III breast cancer. (1997)

Optimal management of locally advanced breast cancer (stage III) generally includes a combination of primary chemotherapy followed by surgery (if feasible), and local radiotherapy and adjuvant chemotherapy with or without hormonal therapy. An ongoing phase II study is being performed to evaluate the use of 4 cycles of 100 mg/m2 of docetaxel (Taxotere) administered as a 1-hour intravenous infusion once every 3 weeks followed by surgery, 4 cycles of standard-dose doxorubicin/cyclophosphamide (Cytoxan, Neosar) chemotherapy, and radiation, with and without tamoxifen (Nolvadex) in patients with locally advanced breast cancer. Preliminary results from 33 patients included in this phase II study are reported here. A partial response was achieved in 22 patients (67%), with 6 patients (18%) experiencing a complete response with this regimen. One patient with a complete response was confirmed to have a complete pathologic response at the time of surgery. Febrile neutropenia was noted in 8 patients (24%) and in 8 of the 120 treatment cycles (7%) administered. Future trials aimed at increasing the number of pathologic complete responses in patients with stage III breast cancer may require the use of docetaxel in combination with other active agents or the use of dose-dense scheduling schemes.
Formation of Flavor Compounds by the Reactions of Carbonyls and Ammonium Sulfide under Low Temperature (2005)

Aqueous mixtures containing α-hydroxyketones (3-hydroxy-2-butanone, 1-hydroxy-2-propanone, 1-hydroxy-2-butanone) or α-dicarbonyls (2,3-butanedione, 2,3-pentanedione) and ammonium sulfide were reacted at 25 °C for 2 hr. Among the heterocyclic flavor compounds formed were oxazoles, oxazolines, thiazoles, thiazolines and pyrazines. 2-(1-Hydroxyalkyl)-3 -oxazolines and 2-( 1-hydroxyalkyl)-3-thiazolines were major intermediate compounds identified in α-hydroxyketone systems and on the other hand, 5-hydroxy-3-oxazolines and 5-hydroxy-3-thiazolines were proposed as intermediate compounds in α-dicarbonyl systems.
Home gateway architecture and its implementation (2002)

We proposed the home gateway architecture. We have implemented the Web server based home gateway, interconnecting IEEE 1394, the powerline home automation network, and the Internet, with real-time AV transcoding capability.
Growth and characterization of the spectra of EuAlO_3:Ti and GdAIO_3:Ti (1989)

Two titanium-doped perovskites, EuAlO3 and GdAlO3, have been grown by laser-heated pedestal growth as potential visible–near-infrared lasers. The absorption spectra of EuAlO3:Ti and the lack of Ti3+ fluorescence from this material indicate the dominance of a charge-transfer transition between titanium and europium. The spectra of GdAlO3:Ti in the visible region are consistent with Ti3+ in an octahedral field. The absence of the charge-transfer transitions in the spectra of GdAlO3:Ti is due to the third ionization potential of Gd’s being approximately 4 eV smaller than that of Eu. GdA1O3:Ti has potential as a tunable-laser material with a center wavelength of 610 nm.