gebhart/patrepeval huggingface dataset:
Relative Importance of Different Water Categories as Sources of N-Nitrosamine Precursors (2016)

A comparison of loadings of N-nitrosamines and their precursors from different source water categories is needed to design effective source water blending strategies. Previous research using Formation Potential (FP) chloramination protocols (high dose and prolonged contact times) raised concerns about precursor loadings from various source water categories, but differences in the protocols employed rendered comparisons difficult. In this study, we applied Uniform Formation Condition (UFC) chloramination and ozonation protocols mimicking typical disinfection practice to compare loadings of ambient specific and total N-nitrosamines as well as chloramine-reactive and ozone-reactive precursors in 47 samples, including 6 pristine headwaters, 16 eutrophic waters, 4 agricultural runoff samples, 9 stormwater runoff samples, and 12 municipal wastewater effluents. N-Nitrosodimethylamine (NDMA) formation from UFC and FP chloramination protocols did not correlate, with NDMA FP often being significant in samples where no NDMA formed under UFC conditions. N-Nitrosamines and their precursors were negligible in pristine headwaters. Conventional, and to a lesser degree, nutrient removal wastewater effluents were the dominant source of NDMA and its chloramine- and ozone-reactive precursors. While wastewater effluents were dominant sources of TONO and their precursors, algal blooms, and to a lesser degree agricultural or stormwater runoff, could be important where they affect a major fraction of the water supply.
Arterial Plasma Potassium Measured Continuously during Exercise in Man (1984)

Five continuous records of arterial plasma potassium were obtained from three normal subjects during brief periods (5-7 min) of exercise (100 W). In two of these subjects hepatic venous blood samples were withdrawn at 0.5-1.0 min intervals and analysed in vitro for plasma potassium. Arterial plasma potassium rose rapidly at the start of exercise from 3.8 +/- 0.3 mmol/l (mean +/- SD) to plateau levels of 5.4 +/- 0.1 mmol/l. One of the above subjects and a further subject were studied after beta-blockade with propranolol. This resulted in an exaggerated rise in arterial plasma potassium during exercise. Hepatic venous potassium measurements indicated that the liver probably had little effect on potassium changes during exercise. The changes in arterial plasma potassium during exercise are rapid and substantial. If transmitted to the extracellular fluid these changes would alter cell transmembrane potential and might as a result alter receptor sensitivity.
Automatic Generation of Event Trees and Fault Trees: A Model-Based Approach (2022)

In the past few decades, the increasing complexity of modern engineering systems has been driven by the integration of a large number of components whose operations may involve many disciplines (e.g., thermal hydraulics, plant operations, cybersecurity). Most computational tools used by industry and regulators for system safety and reliability assessments are still based on the traditional fault tree (FT) and event tree (ET) approach, which may not be able to capture complex interactions among system constituents. The use of simulation tools has widely increased in the past few decades to improve the fidelity of the reliability and safety analyses. However, the direct use of simulation tools as part of dynamic probabilistic risk assessment (DPRA) methods is not getting traction since (1) modeling the whole system under consideration with DPRA methods may be computationally expensive and unnecessary, and (2) the manual integration of DPRA models into existing state-of-practice probabilistic risk assessment models (i.e., based on FTs and ETs) can be time consuming and prone to errors. In this paper we propose a procedure to overcome this limitation by presenting several algorithms designed to automatically construct subsystem ETs and FTs from DPRA methods for integration into an existing ET/FT system model.
Rapid Eradication of a Bulky Melanoma Mass with One Dose of Immunotherapy (2015)

Tumor responses to immunotherapy are highly variable in onset and duration. Responses are often delayed and follow what appears to be progression. However, rapid responses also happen and can result in the disappearance of large lesions, leaving holes and cavities in their wake.
Do People and Neural Nets Pay Attention to the Same Words (2020)

We investigated how users evaluate passage-length answers for non-factoid questions. We conduct a study where answers were presented to users, sometimes shown with automatic word highlighting. Users were tasked with evaluating answer quality, correctness, completeness, and conciseness. Words in the answer were also annotated, both explicitly through user mark up and implicitly through user gaze data obtained from eye-tracking. Our results show that the correctness of an answer strongly depends on its completeness, conciseness is less important.
Topical Anesthesia in Phacotrabeculectomy (2002)

Topical 2% lidocaine hydrochloride jelly without systemic sedation may be a safe and effective anesthetic method in phacotrabeculectomy for patients with primary open-angle glaucoma with coexisting cataract.
Human B cell line deficient in the expression of B cell‐specific glycoproteins (GP 27,35) (1977)

A human B lymphoid cell line, P3HR-1, expresses only low levels of the 27 000 and 35 000 mol.wt. B cell-specific glycoproteins (GP 27,35). Indirect antibody-binding and quantitative absorption tests with a xenoantiserum against the antigens showed that P3HR-1 cells have on their surface about 1% of the amount found on other human B lymphoblastoid cell lines. The deficit of the glycoproteins on the surface of P3HR-1 cells could be accounted for by a reduced rate of synthesis in these cells. A simple relationship between the reduced expression of GP 27,35 on P3HR-1 cells and their inability to bind Epstein-Barr virus (EBV) or express complement receptors was excluded because other B lymphoid cells which expressed neither virus-binding sites nor complement receptor had normal amounts of GP 27,35 on their surface. However, antibodies against GP 27,35 could block the absorption of EBV by EBV receptor-positive B cells.
Selective versus multi-segmental decompression and fusion for multi-segment lumbar spinal stenosis with single-segment degenerative spondylolisthesis (2019)

Selective decompression and fusion is a safe and effective method for the treatment of MLSS, with the advantages of shorter operative time, less blood loss, and more preservation of spinal motion segments when compared with multi-segmental decompression and fusion.
Science and technology: Metering gets real (1994)

Despite vigorous, prolonged, and widespread activity, conventional automatic meter reading (AMR) has for three decades remained an industry-in-waiting, with sparse sales and little deployment relative to its huge target market. Will real-time metering, with its dramatically greater promise for the utility industry, suffer the same fate The authors think not. Since June 1992, UTILEX Inc. has been conducting in two North Carolina towns the nation's first field trial of real-time metering, fully sponsored by the US Department of Energy. Because the technology can signal over ordinary telephone lines even while they are in use - whether for voice, fax, or modem - the system is able to collect not only meter readings, but also continuous five-minute demand profiles, measure the results of demand-side management (DSM) actions, and monitor power outages at individual meter sites. The system needs no special meters, no load recorders, and no batteries. It does not use the telephone company's test trunk, and requires no additional equipment in the telephone company's central office. Operation is unobtrusive to the customer, to the telephone system, and to the meter, and is under the full control of the utility at all times. The system is also compatible with planned evolutionsmore » in telephony.« less
Long Range Enhancement of Molecular Fluorescence by Closely Packed Submicro-scale Ag Islands (2009)

We found that closely packed submicro-scale Ag islands (each ∼370 nm across and ∼90 nm in height on the average) produced not only extremely short-range fluorescence enhancement for rhodamine dye (RhB) placed only ∼1 nm away from the metal surface, but also a novel, long-range enhancement for the same dye for the metal—molecule distance up to ∼50 nm. The net enhancement factor for the spin-coated RhB, with a fluorescence quantum yield of ∼2 % in the absence of Ag islands, was as high as ∼20-folds at the metal--molecule distance of ∼30 nm. We propose that strong interparticle surface plasmon interactions involving such large Ag islands play crucial roles for the long-range fluorescence enhancement. [DOI: 10.1380/ejssnt.2009.653]
Ultralight Multifunctional Carbon‐Based Aerogels by Combining Graphene Oxide and Bacterial Cellulose (2017)

Nanostructured carbon aerogels with outstanding physicochemical properties have exhibited great application potentials in widespread fields and therefore attracted extensive attentions recently. It is still a challenge so far to develop flexible and economical routes to fabricate high-performance nanocarbon aerogels, preferably based on renewable resources. Here, ultralight and multifunctional reduced graphene oxide/carbon nanofiber (RGO/CNF) aerogels are fabricated from graphene oxide and low-cost, industrially produced bacterial cellulose by a three-step process of freeze-casting, freeze-drying, and pyrolysis. The prepared RGO/CNF aerogel possesses a very low apparent density in the range of 0.7-10.2 mg cm<sup>-3</sup> and a high porosity up to 99%, as well as a mechanically robust and electrically conductive 3D network structure, which makes it to be an excellent candidate as absorber for oil clean-up and an ideal platform for constructing flexible and stretchable conductors.
Analysis of the Electric Field in Porcelain Pin-Type Insulators via Finite Elements Software (2018)

In the electrical distribution system, the insulating components may have their characteristics compromised by several reasons such as contamination, cracks caused by vandalism, nest of birds, among others. The influence that each type of variation can cause on its insulation capacity is difficult to determine and must be specifically studied. This article has as objective the evaluation through simulation of the electrical field distribution on the surface of insulators, considering the ambient conditions to which such components are subjected. The finite element software will be used to evaluate the degree of changes due to such conditions in the distribution of the electric field on the surface of insulators. This evaluation shows that the conductive surface significantly reduces the distance from the electric potential to the ground, which makes this condition favorable for electric discharges and therefore must be controlled.
Characterization of MCL-1 in patients with colorectal cancer (CRC): Expression, molecular profiles, and outcomes. (2023)

3085 Background: Myeloid cell leukemia 1 (MCL-1) is a member of the BCL-2 protein family and is anti-apoptotic/pro-survival in function. Dysregulation of MCL-1 expression has been reported in several solid tumors, including lung and breast cancer. In CRC, MCL-1 has been associated with resistance to chemotherapeutic drugs and multi-kinase inhibitor regorafenib. Our study aimed to characterize the molecular features associated with MCL-1 gene expression in CRC. Methods: 28,576 CRC samples were analyzed by Caris Life Sciences (Phoenix, AZ) with WTS (Illumina NovaSeq) and NextGen DNA sequencing (NextSeq, 592 Genes and NovaSEQ, WES). MCL-1 expression was stratified by quartiles where top quartile transcripts per million (TPM) were considered high (Q4) and bottom quartile low (Q1). Cell infiltration (CI) in the tumor microenvironment (TME) was estimated by RNA deconvolution analysis using QuantiSEQ. Interferon-gamma and T-cell inflamed signatures were also calculated from RNA data. X2 and Fisher-Exact tests were used, and statistical significance was determined as a P-value adjusted for multiple comparisons ( q &lt; 0.05). Real world survival was obtained from insurance claims data and Kaplan-Meier estimates were calculated for molecularly defined patients. Results: MCL-1 expression was significantly increased in rectal tumors compared to other primary tumor sites (median TPM [mTPM] 20.8 vs 18.9 vs 18.7, in rectal vs left-sided vs right-sided, respectively, q &lt; 0.0001). MCL-1 high tumors were associated with increased rate of PD-L1 IHC levels (Q1 vs Q4: 4.2% vs 9.7% [all CRC]; 3.7% vs 8.9% [pMMR/MSS], q &lt; 0.0001), while MCL-1-low showed marginally increased rates of TMB-high (8.0% vs 7.0% [all CRC]; 3.3% vs 2.6% [pMMR/MSS], P &lt; 0.05). MCL-1-high expression was associated with a higher T-cell inflamed signature and IFN score ( q &lt; 0.0001). MCL-1 high was associated with higher mutation rates of CDKN2A, BRCA2, KRAS and GNAS, while lower mutation rates of TP53, PIK3CA, PTEN, BRAF, APC, FBXW7, AMER1, SOX9, and SMAD2 and copy number amplifications in several genes ( q &lt; 0.05). MCL-1 high TME had higher CI of M1 and M2 macrophages, monocytes, B cells, NK cells, and T-reg infiltration, while dendritic cells and CD4+ T-cell were lower ( q &lt; 0.05). Patients with high MCL-1 expressing CRC had longer survival (Q4 vs Q1: 33.5 vs 24.8 months, HR 0.72, 95% CI 0.67-0.77, P &lt; 0.0001) and longer time-on-treatment with regorafenib although with limited clinical benefit (Q4 vs Q1: 2.03 vs 1.06 months, HR: 0.67, 95% CI: 0.50-0.89, P = 0.005). Conclusions: Our data show a strong correlation between distinct immune biomarkers, TME cell infiltration and MCL-1 expression in CRC. Furthermore, increased tumor MCL-1 expression improved patient prognosis and treatment outcomes. These findings suggest a key clinical role for MCL-1 as an important modulator of anti-tumor immunity and TME and a potential biomarker in CRC.
Evaluation of the role of surface pretreatments on the corrosion process. Correlation between conventional and electrochemical tests (2017)

The influence on the anticorrosion properties of three different pretreatments applied on steel panels, before being powder‐paint coated, is investigated both by conventional tests (cross cut, impact resistance, and neutral salt spray tests) and electrochemical tests (electrochemical impedance spectroscopy (EIS) and accelerated cyclic electrochemical technique (ACET)). Amorphous phosphate, microcrystalline phosphate, and a sol‐gel, based on 3‐aminopropyltriethoxysilane (APTES), were the different pretreatments that were analyzed. All of them were compared with a non‐pretreated coated carbon steel panel. The microcrystalline phosphate, followed by the sol‐gel surface treatments, showed the best system properties. These good results are attributed to ions available at the interface, and to covalent bonds generated by the silicon network and the substrate surface, respectively.
Multimode interference coupler for mode division multiplexed systems (2022)

&lt;p&gt;Multimode interference (MMI) coupler for multimode system is proposed based on Si waveguide platform. Each mode is separated and injected into the mNxmN MMI coupler with m being the number of modes and N is the multiplication number of input image. &lt;/p&gt;
A Multiobjective Music Recommendation Approach For Aspect-Based Diversification. (2017)

[TODO] Add abstract here.
ChemInform Abstract: Highly Stereoselective trans Addition of π‐Type Nucleophiles to a Bicyclic N‐Acyliminium Ion — Application to the Synthesis of Indolizidine and Pyrrolizidine Alkaloids. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
High-temperature solid-state nuclear magnetic resonance using a poly(amide-imide) spinning system (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHigh-temperature solid-state nuclear magnetic resonance using a poly(amide-imide) spinning systemRichard C. Crosby, James F. Haw, and David H. LewisCite this: Anal. Chem. 1988, 60, 24, 2695–2699Publication Date (Print):December 15, 1988Publication History Published online1 May 2002Published inissue 15 December 1988https://pubs.acs.org/doi/10.1021/ac00175a011https://doi.org/10.1021/ac00175a011research-articleACS PublicationsRequest reuse permissionsArticle Views129Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Graph-based clustering with DRepStream (2017)

Finding and setting input parameters for clustering algorithms is a challenging thing due to the unsupervised nature of clustering. The accuracy of clustering algorithms can be affected greatly by setting parameters appropriately for the dataset, however without ground truth labels and external validation it can be impossible to know when the parameters are set well. In this paper we propose the DRepStream algorithm, which extends the RepStream algorithm. DRepStream uses a graph-based approach, and unlike its predecessor does not require the primary K parameter used in K-nearest neighbour graphs. Our algorithm automatically computes the number of outgoing edges for each vertex in the graph using a computed metric known as the anomalous edge score. We evaluate the performance of our algorithm on other previous stream clustering algorithms on real world benchmark datasets.
Principles in practice: reflections on a `postpositivist' approach to evaluation research (2001)

User participation is currently seen as an ethically appropriate way to proceed when researching disadvantaged groups and it is encouraged by funding agencies. However, the literature rarely discusses the methodological and practical implications for researchers attempting to incorporate user participation into evaluation studies which are informed from an epistemologically opposed (positivist) research paradigm. The paper explores this issue by drawing on the evaluation of a community-based smoking intervention to describe and reflect upon the recruitment, training and employment of local residents as survey interviewers. While the evaluation methodology adopts a quasi-experimental approach, the appointment of local residents as survey interviewers reflects an alternative (interpretive) research tradition. The combined strategy constitutes a postpositivist methodology in that it combines a data collection strategy more akin to interpretive social science while retaining a positivistic epistemological framework. The paper describes some logistics of this approach and problems encountered during the course of survey. While many of the problems described may be routinely associated (although seldom aired) with survey work, particularly in disadvantaged areas, the paper suggests they are also a function of the postpositivist research strategy which we adopted. The failure to involve interviewers in the conception and development of the evaluation meant that they lacked identification with our endeavour and this had practical implications for the survey interviewing. Although the survey was successfully executed and the employment of local residents was a valuable and worthwhile experience, the authors recognize that this narrow conception of user involvement meant that many of the potential benefits (both to the research and the participants) associated with participatory approaches were forfeited.
Average SIR estimation in cellular networks with best server policy (2010)

The evaluation of the Signal to Interference Ratio (SIR) in cellular networks is of primary importance for network dimensioning. For static studies, which evaluate cell capacity and coverage, as well as for dynamic studies, which consider arrivals and departures of mobile stations (MS), the SIR is always an important input. Contrary to most of the analytical works evaluating SIR, we assume in this paper that the MS is attached to the best server, i.e., to the base station (BS) from which it receives the highest power. This is a policy that is more realistic than the classical assumption that considers MSs to be attached to the nearest BS. The exact formulation of the SIR is however in this case uneasy to handle and numerical methods remain heavy. In this paper, we thus propose an approximate analytical study based on truncated lognormal distributions that provides very close results to Monte Carlo simulations.
Conditional Expression of a Gi-Coupled Receptor in Osteoblasts Results in Trabecular Osteopenia (2007)

G protein-coupled receptors (GPCRs) coupled to activation of Gs, such as the PTH1 receptor (PTH1R), have long been known to regulate skeletal function and homeostasis. However, the role of GPCRs coupled to other G proteins such as Gi is not well established. We used the tet-off system to regulate the expression of an activated Gi-coupled GPCR (Ro1) in osteoblasts in vivo. Skeletal phenotypes were assessed in mice expressing Ro1 from conception, from late stages of embryogenesis, and after weaning. Long bones were assessed histologically and by microcomputed tomography. Expression of Ro1 from conception resulted in neonatal lethality that was associated with reduced bone mineralization. Expression of Ro1 starting at late embryogenesis resulted in a severe trabecular bone deficit at 12 wk of age (>51% reduction in trabecular bone volume fraction in the proximal tibia compared with sex-matched control littermates; n = 11; P < 0.01). Ro1 expression for 8 wk beginning at 4 wk of age resulted in a more than 20% reduction in trabecular bone volume fraction compared with sex-matched control littermates (n = 16; P < 0.01). Bone histomorphometry revealed that Ro1 expression is associated with reduced rates of bone formation and mineral apposition without a significant change in osteoblast or osteoclast surface. Our results indicate that signaling by a Gi-coupled GPCR in osteoblasts leads to osteopenia resulting from a reduction in trabecular bone formation. The severity of the phenotype is related to the timing and duration of Ro1 expression during growth and development. The skeletal phenotype in Ro1 mice bears some similarity to that produced by knockout of Gs-alpha expression in osteoblasts and thus may be due at least in part to Gi-mediated inhibition of adenylyl cyclase.