gebhart/patrepeval huggingface dataset:
Double stage and combining detection for cyclo-stationary feature (2012)

Cyclo-stationary feature detection for scattered pilot OFDM symbol is accurate detection technique under low signal power. It is, however, problematic that guard interval insertion degrades the cyclo-stationary feature. We have proposed the silent period detection for the compensation of degrading cyclo-stationary. Even if the proposed technique achieved high accurate detection, it sacrifices the loss of guard interval energy. In this paper, we modify the proposed detection technique for cylco-stationary feature detection. For recovering the loss of energy, we propose double stage detector and combining technique. We show the effect of these modifications by computer simulation.
Characteristic of a DB(dialytic battery) generation using pressurized saline water. (1999)

A saline water DB (dialytic battery) was modified by using pressurized saline water. Internal resistance was increased with increased pressure. The output power of modified battery was drastically increased as much as double of the former DB battery.
Improved volumetric imaging in tomosynthesis using combined multiaxial sweeps (2010)

This study explores the volumetric reconstruction fidelity attainable using tomosynthesis with a kV imaging system which has a unique ability to rotate isocentrically and with multiple degrees of mechanical freedom. More specifically, we seek to investigate volumetric reconstructions by combining multiple limited-angle rotational image acquisition sweeps. By comparing these reconstructed images with those of a CBCT reconstruction, we can gauge the volumetric fidelity of the reconstructions. In surgical situations, the described tomosynthesis-based system could provide high-quality volumetric imaging without requiring patient motion, even with rotational limitations present. Projections were acquired using the Digital Integrated Brachytherapy Unit, or IBU-D. A phantom was used which contained several spherical objects of varying contrast. Using image projections acquired during isocentric sweeps around the phantom, reconstructions were performed by filtered backprojection. For each image acquisition sweep configuration, a contrasting sphere is analyzed using two metrics and compared to a gold standard CBCT reconstruction. Since the intersection of a reconstructed sphere and an imaging plane is ideally a circle with an eccentricity of zero, the first metric presented compares the effective eccentricity of intersections of reconstructed volumes and imaging planes. As another metric of volumetric reconstruction fidelity, the volume of one of the contrasting spheres was determined using manual contouring. By comparing these manually delineated volumes with a CBCT reconstruction, we can gauge the volumetric fidelity of reconstructions. The configuration which yielded the highest overall volumetric reconstruction fidelity, as determined by effective eccentricities and volumetric contouring, consisted of two orthogonally-offset 60° L-arm sweeps and a single C-arm sweep which shared a pivot point with one the L-arm sweeps. When compared to a similar configuration that lacked the C-arm component, it is shown that the C-arm improves the delineation of volumes along the transverse axis. The results described herein suggest that volumetric reconstruction using multiple, unconstrained orthogonal sweeps can provide an improvement compared with traditional cone beam CT using standard axial rotations.
Effect of Inhaled Xenon on Cardiac Function in Comatose Survivors of Out-of-Hospital Cardiac Arrest—A Substudy of the Xenon in Combination With Hypothermia After Cardiac Arrest Trial (2021)

Among comatose survivors of a cardiac cause out-of-hospital cardiac arrest, inhaled xenon combined with hypothermia was associated with greater recovery of left ventricular systolic function in comparison with hypothermia alone.
The E-Business WorkPlace: Discovering the Power of Enterprise Portals (2001)

From the Publisher:
Make The E-Business Workplace Work For You From the consultants at PricewaterhouseCoopers and SAP come the keys to understanding and taking advantage of the most exciting development in the world of business technologythe e-business workplace. Written in language that is accessible to all executives and managers, in any company and industrynot just to information technology professionalsthe authors explain how this user-oriented, people-friendly technology can transform your organization by empowering collaboration among its employees and value network partners. Here are answers to such critical questions as: *How can you use workplace technology to move from integration to true collaboration?*What are the advantages of a truly people-friendly technology?*Does workplace technology add value?*How are roles different from jobs, and how does the e-business workplace use roles to help people perform their jobs more effectively and efficiently?*What are the components of workplace technology software, and how do you choose a product best suited to your organization?*Can the e-business workplace help your organization manage change?*Where does workplace technology fit within the broader e-business context?*Can the e-business workplace help your organization achieve its vision?In answering these questions, the authors support their conclusions with numerous real-world examples that move the theory behind workplace technology into practice. The E-Business Workplace also provides insights and knowledge found nowhere else, based on the thousands of technology implementations in which they and their organizations have been integrally involved. Take this opportunity to learn about acritically important technology that may be the defining factor in determining success and failure in an increasingly complex Internet-enabled economy.
Understanding Comprehension Levels of Emergency Notifications by Limited English Proficient US Residents: Case Study of Korean-Americans in New York City (2015)

Abstract The overall goal of this study was to examine any validity of emerging concerns about the effectiveness and usefulness of a single language public messaging system in a linguistically diverse environment by evaluating the level of understanding of Notify NYC messages among Korean LEP residents of New York City. Three task oriented objectives were completed to address the goal of this study: (1) using past Notify NYC messages, a survey to test comprehension levels among Korean LEP residents was created; (2) the survey was administered among two population samples, Korean LEP and native English speaking (NES); and (3) statistical analysis was employed to correlate the data, conduct testing of three hypotheses, and develop appropriate conclusions. The results demonstrate that primary challenges with effective use of a single-language system in providing emergency communication to LEP residents stem from the language barriers that exist for this population category in the US. The positive pattern correlation and high coefficient of determination imply that improving the clarity of the emergency messages could enhance the overall message comprehension among the LEP US residents.
Compression of frequency-modulated pulses by dynamic scattering in the Laue geometry (1989)

It is shown that, in principle, it is possible to compress frequency-modulated x-ray and optical radiation pulses by dynamic scattering in linearly periodic inhomogeneous media.
Solution Structure of the Dickerson DNA Dodecamer Containing a Single Ribonucleotide (2012)

Ribonucleotides are frequently incorporated into DNA during replication. They are recognized and processed by several cellular enzymes, and their continued presence in the yeast nuclear genome results in replicative stress and genome instability. Thus, it is important to understand the effects of isolated ribonucleotide incorporation on DNA structure. With this goal in mind, we describe the nuclear magnetic resonance structure of the self-complementary Dickerson dodecamer sequence [d(CGC)rGd(AATTCGCG)](2) containing two symmetrically positioned riboguanosines. The absence of an observable H(1)-H(2) scalar coupling interaction indicates a C3'-endo conformation for the ribose. Longer-range structural perturbations resulting from the presence of the ribonucleotide are limited to the adjacent and transhelical nucleotides, while the global B-form DNA structure is maintained. Because crystallographic studies have indicated that isolated ribonucleotides promote global B → A transitions, we also performed molecular modeling analyses to evaluate the structural consequences of higher ribonucleotide substitution levels. Increasing the ribonucleotide content increased the minor groove width toward values more similar to that of A-DNA, but even 50% ribonucleotide substitution did not fully convert the B-DNA to A-DNA. Comparing our structure with the structure of an RNase H2-bound DNA supports the conclusion that, as with other DNA-protein complexes, the DNA conformation is strongly influenced by the interaction with the protein.
Comparative N-Glycan Profiling of Colorectal Cancer Cell Lines Reveals Unique Bisecting GlcNAc and α-2,3-Linked Sialic Acid Determinants Are Associated with Membrane Proteins of the More Metastatic/Aggressive Cell Lines (2013)

Advances in colorectal cancer (CRC) diagnosis will be enhanced by development of more sensitive and reliable methods for early detection of the disease when treatment is more effective. Because many known disease biomarkers are membrane-bound glycoproteins with important biological functions, we chose to compare N-glycan profiles of membrane proteins from three phenotypically different CRC cell lines, LIM1215, LIM1899, and LIM2405, representing moderately differentiated metastatic, moderately differentiated primary, and poorly differentiated (aggressive) primary CRC cell lines, respectively. The N-glycan structures and their relative abundances were determined as their underivatized reduced forms, using porous graphitized carbon LC-ESI-MS/MS. A key observation was the similar N-glycan landscape in these cells with the dominance of high mannose type glycan structures (70-90%) in all three cell lines, suggesting an incomplete glycan processing. Importantly, unique glycan determinants such as bisecting N-acetylglucosamine were observed at a high level in the metastatic LIM1215 cells, with some expressed in the moderately differentiated LIM1899, while none were detected in the poorly differentiated LIM2405 cells. Conversely, α-2,3-sialylation was completely absent in LIM1215 and LIM1899 and present only in LIM2405. RNA-Seq and lectin immunofluorescence data correlated well with these data, showing the highest upregulation of Mgat3 and binding with PHA-E in LIM1215. Downregulation of Man1α1 and Mgat1 in LIM1215 also coincided with the higher degree of incomplete N-glycan processing and accumulation of high mannose type structures as well as bisecting N-glycans when compared to the other two cell lines. This study provides a comprehensive analysis of the membrane N-glycome in three CRC cell lines and identifies N-glycosylation differences that correlate with the histological and pathological features of the cell lines. The unique glycosylation phenotypes may therefore serve as a molecular feature to differentiate CRC disease stages.
Inhibition of cathepsin B by caspase-3 inhibitors blocks programmed cell death in Arabidopsis (2016)

Programmed cell death (PCD) is used by plants for development and survival to biotic and abiotic stresses. The role of caspases in PCD is well established in animal cells. Over the past 15 years, the importance of caspase-3-like enzymatic activity for plant PCD completion has been widely documented despite the absence of caspase orthologues. In particular, caspase-3 inhibitors blocked nearly all plant PCD tested. Here, we affinity-purified a plant caspase-3-like activity using a biotin-labelled caspase-3 inhibitor and identified Arabidopsis thaliana cathepsin B3 (AtCathB3) by liquid chromatography with tandem mass spectrometry (LC-MS/MS). Consistent with this, recombinant AtCathB3 was found to have caspase-3-like activity and to be inhibited by caspase-3 inhibitors. AtCathepsin B triple-mutant lines showed reduced caspase-3-like enzymatic activity and reduced labelling with activity-based caspase-3 probes. Importantly, AtCathepsin B triple mutants showed a strong reduction in the PCD induced by ultraviolet (UV), oxidative stress (H2O2, methyl viologen) or endoplasmic reticulum stress. Our observations contribute to explain why caspase-3 inhibitors inhibit plant PCD and provide new tools to further plant PCD research. The fact that cathepsin B does regulate PCD in both animal and plant cells suggests that this protease may be part of an ancestral PCD pathway pre-existing the plant/animal divergence that needs further characterisation.
Experimental Pediatric Arterial Ischemic Stroke Model Reveals Sex-specific Estrogen Signaling (2013)

Focal ischemia has fundamentally different effects in the juvenile brain compared with the adult, as evidenced by the lack of sex difference in ischemic injury in the murine postnatal day 20 to 25 middle cerebral artery occlusion model and the sexually dimorphic response to estrogen neuroprotection.
DNA Methylation in Patients with Colorectal Cancer - Correlation with Some Clinical and Morphological Features and with Local Tumour Invasion (2010)

Tumours with microsatellite instability, high level methylation and CIMP have distinctive clinical and morphological features. The level of hMLH1 and TIMP3 methylation and CIMP status can be correlated with the local tumour invasion. Different mechanisms, even for one and the same patient, can be responsible for the development of more than one third of the synchronous polyps and carcinomas.
InterViso: a data integration server (2002)

Connectivity products are available to connect computers containing data. DBMS vendors are providing gateways into their products, and SQL is being retrofitted on many older DBMSs to make it easier to access data from standard 4GL products and application development systems. The next step needed for integration of data is to provide a common data dictionary with a conceptual schema across the data to mask the many differences that occur when databases are developed independently. Data Integration Inc. has two products for addressing the problem: the InterViso IVBuild for developing the common data dictionary, and InterViso IVQuery for access to diverse databases. IVQuery is a DBMS front-end that allows a user to access data that is managed by existing DBMSs. IVQuery needs the definition of the existing databases, "local schemas" and a view across the databases, the "federated schema", which are stored in a DD/D (data dictionary /directory). The DD/D Builder program, called IVBuild, is used to develop and maintain the DD/D. IVBuild differs from other data modeling tools in that the description of the individual databases is input rather than output.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Adaptive stabilization of second-order non-minimum phase systems (2004)

We consider the adaptive output convergence for a class of unstable non-minimum-phase second-order relative-degree-one linear systems with unknown constant coefficients. The coefficient uncertainty bounds are required to be known and to satisfy an inequality constraint. We illustrate the use of the controller with several example systems.
Circulating SPINT1 Is Reduced in a Preeclamptic Cohort with Co-Existing Fetal Growth Restriction (2022)

Fetal growth restriction (FGR), when undetected antenatally, is the biggest risk factor for preventable stillbirth. Maternal circulating SPINT1 is reduced in pregnancies, which ultimately deliver small for gestational age (SGA) infants at term (birthweight < 10th centile), compared to appropriate for gestational age (AGA) infants (birthweight ≥ 10th centile). SPINT1 is also reduced in FGR diagnosed before 34 weeks' gestation. We hypothesised that circulating SPINT1 would be decreased in co-existing preterm preeclampsia and FGR. Plasma SPINT1 was measured in samples obtained from two double-blind, randomised therapeutic trials. In the Preeclampsia Intervention with Esomeprazole trial, circulating SPINT1 was decreased in women with preeclampsia who delivered SGA infants (<i>n</i> = 75, median = 18,857 pg/mL, IQR 10,782-29,890 pg/mL, <i>p</i> < 0.0001), relative to those delivering AGA (<i>n</i> = 22, median = 40,168 pg/mL, IQR 22,342-75,172 pg/mL). This was confirmed in the Preeclampsia Intervention 2 with metformin trial where levels of SPINT1 in maternal circulation were reduced in SGA pregnancies (<i>n</i> = 95, median = 57,764 pg/mL, IQR 42,212-91,356 pg/mL, <i>p</i> < 0.0001) compared to AGA controls (<i>n</i> = 40, median = 107,062 pg/mL, IQR 70,183-176,532 pg/mL). Placental Growth Factor (PlGF) and sFlt-1 were also measured. PlGF was significantly reduced in the SGA pregnancies, while ratios of sFlt-1/SPINT1 and sFlt1/PlGF were significantly increased. This is the first study to demonstrate significantly reduced SPINT1 in co-existing FGR and preeclamptic pregnancies.
Nuclear distribution and chromatin association of DNA polymerase α-primase is affected by TEV protease cleavage of Cdc23 (Mcm10) in fission yeast (2005)

An important function of Cdc23 in the elongation step of DNA replication may be to assist in the docking of DNA polymerase alpha-primase to chromatin.
Crystalline Molecular Materials: From Structure to Function (2020)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTCrystalline Molecular Materials: From Structure to FunctionKathryn Preuss*Kathryn Preuss*Email: [email protected]More by Kathryn Preusshttp://orcid.org/0000-0003-2342-5346, Ashlee HowarthAshlee HowarthMore by Ashlee Howarthhttp://orcid.org/0000-0002-9180-4084, and Louise DaweLouise DaweMore by Louise Dawehttp://orcid.org/0000-0003-3630-990XCite this: Cryst. Growth Des. 2020, 20, 12, 7565–7567Publication Date (Web):October 28, 2020Publication History Published online28 October 2020Published inissue 2 December 2020https://pubs.acs.org/doi/10.1021/acs.cgd.0c01360https://doi.org/10.1021/acs.cgd.0c01360editorialACS PublicationsCopyright © 2020 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views2260Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (541 KB) Get e-AlertscloseSUBJECTS:Magnetic properties,Metal organic frameworks,Morphology,Noncovalent interactions,Supramolecular structures and assemblies Get e-Alerts
Phase Variation of Ag43 Is Independent of the Oxidation State of OxyR (2003)

OxyR is a DNA binding protein that differentially regulates a cell's response to hydrogen peroxide-mediated oxidative stress. We previously reported that the reduced form of OxyR is sufficient for repression of transcription of agn43 from unmethylated template DNA, which is essential for deoxyadenosine methylase (Dam)- and OxyR-dependent phase variation of agn43. Here we provide evidence that the oxidized form of OxyR [OxyR(ox)] also represses agn43 transcription. In vivo, we found that exogenous addition of hydrogen peroxide, sufficient to oxidize OxyR, did not affect the expression of agn43. OxyR(ox) repressed in vitro transcription but only from an unmethylated agn43 template. The -10 sequence of the promoter and three Dam target sequences were protected in an in vitro DNase I footprint assay by OxyR(ox). Furthermore, OxyR(ox) bound to the agn43 regulatory region DNA with an affinity similar to that for the regulatory regions of katG and oxyS, which are activated by OxyR(ox), indicating that binding at agn43 can occur at biologically relevant concentrations. OxyR-dependent regulation of Ag43 expression is therefore unusual in firstly that OxyR binding at agn43 is dependent on the methylation state of Dam target sequences in its binding site and secondly that OxyR-dependent repression appears to be independent of hydrogen-peroxide mediated oxidative stress and the oxidation state of OxyR.
Targeting the Genome‐Stability Hub Ctf4 by Stapled‐Peptide Design (2017)

The exploitation of synthetic lethality by small-molecule targeting of pathways that maintain genomic stability is an attractive chemotherapeutic approach. The Ctf4/AND-1 protein hub, which links DNA replication, repair, and chromosome segregation, represents a novel target for the synthetic lethality approach. Herein, we report the design, optimization, and validation of double-click stapled peptides encoding the Ctf4-interacting peptide (CIP) of the replicative helicase subunit Sld5. By screening stapling positions in the Sld5 CIP, we identified an unorthodox i,i+6 stapled peptide with improved, submicromolar binding to Ctf4. The mode of interaction with Ctf4 was confirmed by a crystal structure of the stapled Sld5 peptide bound to Ctf4. The stapled Sld5 peptide was able to displace the Ctf4 partner DNA polymerase α from the replisome in yeast extracts. Our study provides proof-of-principle evidence for the development of small-molecule inhibitors of the human CTF4 orthologue AND-1.
The Near Ultraviolet Absorption Spectra of Some Fluorinated Derivatives of Methane and Ethylene1,2 (1950)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Near Ultraviolet Absorption Spectra of Some Fluorinated Derivatives of Methane and Ethylene1,2J. R. Lacher, L. E. Hummel, E. F. Bohmfalk, and J. D. ParkCite this: J. Am. Chem. Soc. 1950, 72, 12, 5486–5489Publication Date (Print):December 1, 1950Publication History Published online1 May 2002Published inissue 1 December 1950https://pubs.acs.org/doi/10.1021/ja01168a029https://doi.org/10.1021/ja01168a029research-articleACS PublicationsRequest reuse permissionsArticle Views158Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts