gebhart/patrepeval huggingface dataset:
Transients from a mixture of [(R(O)Sn)2C(CH3)2]2 and (RCl2Sn)2C(CH3)2 [R = (SiMe3)2CH]: an identification in situ by 1D 119Sn and 2D 1H119Sn HMQC NMR spectroscopy and electrospray mass spectrometry (2003)

Abstract The reaction of the 2,2‐bis(organodichlorostannyl)propane [(Me 3 Si) 2 CH(Cl 2 )Sn] 2 CMe 2 (A) with the corresponding organotin oxide {[(Me 3 Si) 2 CH(O)Sn] 2 CMe 2 } 2 (B) does not provide the corresponding normally expected tetraorganodistannoxane {[(Me 3 Si) 2 CH(Cl)SnCMe 2 Sn(Cl)CH(SiMe 3 ) 2 ]O} n but a complex reaction mixture. One major product, namely the 2,4,6,8‐tetraorgano‐2,6‐dichloro‐1,5,9‐trioxa‐2,4,6,8‐tetrastannabicyclo[3.3.1]nonane derivative [(Me 3 Si) 2 CHSnCMe 2 Sn(Cl)CH(SiMe 3 ) 2 ] 2 O 3 (C) was identified in situ by 2D 1 H 119 Sn and 1 H 13 C heteronuclear multiple quantum coherence and heteronuclear multiple bond correlation NMR spectroscopy as well as electrospray mass spectrometry. Compound C is proposed to be in equilibrium with an ionic species C′, the cation of which has an adamantane‐type structure. Copyright © 2003 John Wiley &amp; Sons, Ltd.
The Design and Assignment of Microgestures to Commands for Virtual and Augmented Reality Tasks (2020)

Researchers have designed 3D (non-contacting) gestures for human-computer interaction (HCI) for desktop computers, automobiles, and augmented and virtual reality (AR/VR) to improve functionality, and experience. 3D gestures provide a method for HCI in clean and dirty environments and settings where both hands need to be free for other tasks such as warehouse work. However, long-term use of 3D gestures may pose a risk of musculoskeletal fatigue especially if the gestures require movement at larger joints such as the shoulder or elbow. Microgestures involve motions of just the fingers and hands thereby reducing muscle fatigue and distraction. Current microgesture lexicons are not well designed for VR or AR systems because of differences in interactive requirements of the commands and context for their use. The purpose of this study was to design microgestures for AR and VR that follow user experiences with existing gestures while considering application, user preference and hand/wrist postures.
Data from The First-in-Human Study of the Hydrogen Sulfate (Hyd-Sulfate) Capsule of the MEK1/2 Inhibitor AZD6244 (ARRY-142886): A Phase I Open-Label Multicenter Trial in Patients with Advanced Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; In part A, the aim was to define the maximum tolerated dose (MTD) of the hydrogen sulfate (Hyd-Sulfate) oral capsule formulation of the mitogen-activated protein kinase kinase inhibitor AZD6244 (ARRY-142886). In part B, the aim was to compare the pharmacokinetic profile of the new Hyd-Sulfate capsule with the initial AZD6244 free-base suspension and further characterize the pharmacodynamic profile and efficacy of the new formulation.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; In part A, 30 patients received escalating doses of AZD6244 Hyd-Sulfate twice daily. In part B, 29 patients were randomized to a single dose of the Hyd-Sulfate capsule or free-base suspension, followed by a washout, then a single dose of the alternative formulation. Patients received the Hyd-Sulfate capsule twice daily at MTD of part A thereafter.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; The MTD of the Hyd-Sulfate capsule was 75 mg twice daily. Dose limiting toxicities were Common Terminology Criteria for Adverse Events grade 3 acneiform rash and pleural effusion. Fatigue (65.7%) and acneiform dermatitis (60.0%) were the most frequent adverse events at the MTD. Based on area under curve&lt;sub&gt;0-24&lt;/sub&gt;, exposure of the 75 mg Hyd-Sulfate capsule relative to the 100 mg free-base suspension was 197% (90% confidence interval, 161-242%). Pharmacodynamic analysis showed that inhibition of 12-&lt;i&gt;O&lt;/i&gt;-tetradecanoylphorbol-13-acetate–induced extracellular signal-regulated kinase phosphorylation in peripheral blood lymphocytes was related to plasma concentrations of AZD6244, with an estimated IC&lt;sub&gt;50&lt;/sub&gt; of 352 ng/mL and maximum inhibition (E&lt;sub&gt;max&lt;/sub&gt;) of ∼91%, showing target inhibition. A patient with metastatic melanoma bearing a V600E &lt;i&gt;BRAF&lt;/i&gt; mutation achieved a complete response persisting after 15 months of therapy.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; The AZD6244 Hyd-Sulfate capsule formulation has shown a favorable toxicity, pharmacokinetic, and pharmacodynamic profile, and is being taken forward in ongoing clinical trials. Clin Cancer Res; 16(5); 1613–23&lt;/p&gt;&lt;/div&gt;
Compressive mechanical modulation alters the viability of growth plate chondrocytes in vitro (2015)

The aim of this study was to investigate the effect of compressive modulation parameters (mode, magnitude, duration, as well as frequency and amplitude for cyclic modulation) on the viability of growth plate chondrocytes. Swine ulnar growth plate explants (n = 60) were randomly distributed among 10 groups: baseline (n = 1 × 6); culture control (n = 1 × 6); static (n = 3 × 6); and dynamic (n = 5 × 6). Static and dynamic samples were modulated in vitro using a bioreactor. Different compression magnitudes (0.1 MPa or 0.2 MPa), durations (12 h or 24 h), frequencies (0.1 Hz or 1.0 Hz), and amplitudes (30% or 100%) were investigated. Viability was assessed by automatic quantification of number of live/dead cells from confocal images of Live/Dead labeled tissues. Chondrocyte viability was found to be dependent on compression magnitude, duration, frequency, and amplitude in a way that increasing each parameter decreased viability in certain zones of growth plate. More specifically, proliferative and hypertrophic chondrocytes were found to be more sensitive to the applied compression. This study provides an in vitro protocol for studying the effects of compressive modulation on biomechanical and biological responses of growth plate explants, which will be useful in finding efficient and non-detrimental parameters for mechanical modulation of bone growth exploited in scoliosis fusionless treatments.
Dynamics of thin liquid films on vertical cylindrical fibers (2018)

Recent experiments of thin films flowing down a vertical fiber with varying nozzle diameters present a wealth of new dynamics that illustrate the need for more advanced theory. We present a detailed analysis using a full lubrication model that includes slip boundary conditions, nonlinear curvature terms, and a film stabilization term. This study brings to focus the presence of a stable liquid layer playing an important role in the full dynamics. We propose a combination of these physical effects to explain the observed velocity and stability of traveling droplets in the experiments and their transition to isolated droplets. This is also supported by stability analysis of the traveling wave solution of the model.
Analytical Investigation of Availability in a Vision Cloud Storage Cluster (2014)

The goal of VISION Cloud, a European Commission funded project, is to design a new scalable and flexible storage cloud architecture able to provide data-intensive storage cloud services. The proposed environment employs a distributed file system on top of a set of storage rich nodes composing a cluster. Several clusters constitute a data center, while multiple geographically distributed data centers form a single storage cloud. In this paper, we focus on a single VISION Cloud storage cluster, providing a stochastic reward net model for an investigation of its availability. The proposed model is a first attempt at obtaining a quantification of the availability level of the cloud storage provided by the VISION Cloud architecture.
Abstract 200: FOXD1 promotes stromal investment in clear cell renal cell carcinoma (2018)

Abstract Forkhead transcription factors (FOX) play a role in the development of many cancers, including clear cell renal cell carcinoma (ccRCC). FOXD1, essential for angiogenesis in the developing kidney, has not previously been implicated in ccRCC. Tumor microarrays (TMAs) containing 41 patient-derived ccRCC tumors and 26 healthy cortex samples were stained for FOXD1, with 65% of tumor samples staining positively. Due to the effect of FOXD1 on angiogenesis, staining for stromal markers PECAM, αSMA, PDGFRβ and NG2 was also performed. A direct correlation was found only between FOXD1 and PDGFRβ (p&amp;lt;4.5x10-6), suggesting interstitial fibroblast recruitment by FOXD1+ cancer cells. Increased expression of FOXD1 was found to correlate with increased stage (p=9.1x10-5) and reduced survival (FOXD1 low= 2830 days; FOXD1 high= 1913 days) from a Kaplan-Meier analysis of RNA-seq data from The Cancer Genome Atlas (TCGA). Potential FOXD1 target binding sites were determined using the TRANSFAC FOXD1 binding site matrix. SLIT2, a factor known to inhibit migration of pericytes, was uncovered from the analysis and was further found to be downregulated in response to FOXD1 overexpression in renal proximal tubule cells (RPTECs). To test the influence of SLIT2 on interstitialfibroblast migration, scratch assays on NRK-49F (rat kidney fibroblast) and Gli-1 (cardiac fibroblast) cells were performed and showed that SLIT2 reduced PDGFBB-induced cell migration (p&amp;lt;0.027). A multiplex proximity ligation assay for multiple signaling pathways showed that SLIT2 treatment reduced the STAT signaling response to PGDFBB. To model the influence of SLIT2 on ccRCC stromal invasion in vitro, we devised a novel 3D invasion assay. In summary, 786-O ccRCC cancer cells were seeded into a 200um thick silk scaffold and cultured for 3 days to allow deposition of ECM. Scaffolds were then placed on top of a monolayer of interstitial fibroblasts and invasion into the cancer cell-filled scaffold was measured using confocal microscopy. The results showed a significant reduction of cell invasion into the cancer-filled matrix with the addition of recombinant SLIT2 to media (5µm p=1.34x10-4; 50µm p=1.64x10-2). In conclusion, we show that FOXD1 expression has prognostic relevance to patient survival in ccRCC, and that this may be due to modulation of SLIT2 expression. Citation Format: Kyle H. Bond, Jennifer Fetting, Ashwani Gupta, Christine W. Duarte, Michele Karolak, Clare B. Congdon, Ivette Emery, Eoghainín Ó hAinmhire, Benjamin D. Humphreys, Leif Oxburgh. FOXD1 promotes stromal investment in clear cell renal cell carcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 200.
Carbon Xerogel Microspheres and Monoliths from Resorcinol–Formaldehyde Mixtures with Varying Dilution Ratios: Preparation, Surface Characteristics, and Electrochemical Double-Layer Capacitances (2013)

Carbon xerogels in the form of microspheres and monoliths were obtained from the sol-gel polymerization of resorcinol and formaldehyde in the presence of potassium carbonate as catalyst, using water as solvent and two different molar dilution ratios. The objectives of this study were as follows: to investigate the effect of the dilution ratio, polymerization reaction time, and temperature on the rheological properties of the sols used to prepare the carbon xerogel microspheres and monoliths; and to determine the influence of their preparation methods and shapes on their surface characteristics and electrochemical double-layer (EDL) capacitance. An increase in the molar dilution ratio produced a decrease in the apparent activation energy of the sol-gel transition. Carbon xerogel microspheres were steam-activated at different burnoff percentages. The morphology, surface area, porosity, and surface chemistry of samples were determined. The main difference between the carbon xerogel microspheres and monoliths was that the latter are largely mesoporous. Better electrochemical behavior was shown by carbon xerogels in monolith than in microsphere form, but higher gravimetric and volumetric capacitances were found in activated carbon xerogel microspheres than in carbon xerogel monoliths.
Reexamination of Shock-Tube Measurements of the Rate Coefficient of H + O2 .fwdarw. OH + O (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReexamination of Shock-Tube Measurements of the Rate Coefficient of H + O2 .fwdarw. OH + OC.-L. Yu, M. Frenklach, D. A. Masten, R. K. Hanson, and C. T. BowmanCite this: J. Phys. Chem. 1994, 98, 17, 4770–4771Publication Date (Print):April 1, 1994Publication History Published online1 May 2002Published inissue 1 April 1994https://pubs.acs.org/doi/10.1021/j100068a048https://doi.org/10.1021/j100068a048research-articleACS PublicationsRequest reuse permissionsArticle Views168Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
XEUS-the X-ray evolving universe spectroscopy mission (2001)

XEUS is under study by ESA as part of the Horizon 2000+ program to utilize the International Space Station (ISS) for astronomical applications. XEUS will be a long-term X-ray observatory with an initial mirror area of 6 m2 at 1 keV that will be grown to 30 m2 following a visit to the ISS. The 1 keV spatial resolution is expected to be 2–5″ HEW. XEUS will consist of separate detector and mirror spacecraft aligned by active control to provide a focal length of 50 m. A new detector spacecraft, complete with the next generation of instruments, will also be added after visiting the ISS. The limiting sensitivity will then be ∼4×10−18 erg cm−2 s−1 around 250 times better than XMM. The properties of a 350 eV (rest-frame) equivalent width Fe line from a 1044 erg s−1 AGN will be measurable out to z=10, paving the way for detailed spectroscopic X-ray studies of some of the earliest known objects.
Obesity and diabetes cause cognitive dysfunction in the absence of accelerated β-amyloid deposition in a novel murine model of mixed or vascular dementia (2014)

Mid-life obesity and type 2 diabetes mellitus (T2DM) confer a modest, increased risk for Alzheimer's disease (AD), though the underlying mechanisms are unknown. We have created a novel mouse model that recapitulates features of T2DM and AD by crossing morbidly obese and diabetic db/db mice with APPΔNL/ΔNLx PS1P264L/P264L knock-in mice. These mice (db/AD) retain many features of the parental lines (e.g. extreme obesity, diabetes, and parenchymal deposition of β-amyloid (Aβ)). The combination of the two diseases led to additional pathologies-perhaps most striking of which was the presence of severe cerebrovascular pathology, including aneurysms and small strokes. Cortical Aβ deposition was not significantly increased in the diabetic mice, though overall expression of presenilin was elevated. Surprisingly, Aβ was not deposited in the vasculature or removed to the plasma, and there was no stimulation of activity or expression of major Aβ-clearing enzymes (neprilysin, insulin degrading enzyme, or endothelin-converting enzyme). The db/AD mice displayed marked cognitive impairment in the Morris Water Maze, compared to either db/db or APPΔNLx PS1P264L mice. We conclude that the diabetes and/or obesity in these mice leads to a destabilization of the vasculature, leading to strokes and that this, in turn, leads to a profound cognitive impairment and that this is unlikely to be directly dependent on Aβ deposition. This model of mixed or vascular dementia provides an exciting new avenue of research into the mechanisms underlying the obesity-related risk for age-related dementia, and will provide a useful tool for the future development of therapeutics.
Implementation of Energy-Neutral Operation on Vibration Energy Harvesting WSN (2019)

This paper presents a method for realizing energy neutral operation on energy harvesting wireless sensor nodes (WSN) and its implementation, regarding that the available environmental energy is unpredictable and changes over time. The method utilizes adaptive duty cycling which provides energy-neutral operation according to the energy available in the environment and the instantaneous energy state of the node through an energy management circuit. The proposed method is implemented using a MicaZ mote as the WSN and two different vibration-based harvesters: piezoelectric and electromagnetic. The node incorporating a piezoelectric harvester, operates for only 130.5 s with a fixed duty-cycle of 0.21%, and requires an inactive time of 93.5 s for charging. On the other hand, with the proposed strategy, the node achieves energy-neutral operation by self-adjusting to 0.17% duty-cycle. Energy-neutral operation is also demonstrated by incorporating an electromagnetic energy harvester attached to the wrist of a runner: When no energy is available for harvesting, the proposed strategy shows about 64% increment in lifetime before going to sleep mode. These demonstrate that the proposed energy management policy proves to achieve energy-neutral operation in an efficient way.
Expandable programmable integrated front-end for scintillator based photodetectors (2012)

Scintillator based photodetectors tend to increase the number of output signals in order to improve spatial and energy resolutions. AMIC architecture was introduced in previous works as an alternative to traditional charge division front-ends. This novel architecture not only allowed to reduce the number of signals to be acquired but also provided more information about the light distribution on the photodetector surface. Another key feature of this new approach lies in its ability to manage any number of inputs, thus offering an expandable solution for photodetectors with a large number of output signals. The underlying idea in AMIC architecture is to calculate the moments of the detected light distribution in an analog fashion. Due to the additive nature of the moment calculation, the operation can be carried out on a single device or split it into several devices, adding the partial results afterwards. A new integrated front-end device AMIC2GR has been developed which improves several features of the original AMIC architecture. A new preamplifier configuration extends the maximum capacitive load thus allowing compatibility with many types of photomultipliers including SiPM without loss of performance. In order to test the expandability of AMIC architecture using the new AMIC2GR, a front end with 4 devices has been developed. Measurements with a 256-SiPM array were made. Furthermore, a new calibration method (Edna Calibration Method) to compensate gain and detector module differences was developed and tested. AMIC2GR allows to calibrate each SiPM individually to obtain better spatial resolution and homogeneity.
Effect of Eicosapentaenoic and Docosahexaenoic Acids Added to Statin Therapy on Coronary Artery Plaque in Patients With Coronary Artery Disease: A Randomized Clinical Trial (2017)

URL: http://www.ClinicalTrials.gov. Unique identifier: NCT01624727.
A simulation of the effects of set-up error and changes in breast volume on conventional and intensity-modulated treatments in breast radiotherapy (2001)

The effect of interfractional patient movement on dosimetry has been investigated for breast radiotherapy. Errors in patient set-up and changes in breast volume were simulated individually to determine how each contributes to the total dosimetric error. Two treatment techniques were investigated: a conventional treatment and an intensity-modulated treatment delivered using compensators. Six patients were investigated and anterior-posterior (AP) and superior-inferior (SI) displacements were simulated by displacing the isocentre in both directions by 2, 5 and 10 mm. A model of the breast was developed from the six patients to simulate changes in breast volume. In this model, the breast was described as a set of semi-ellipses. The volume of the breast was changed by varying the magnitude of the semi-major and semi-minor axes. Anisotropic changes in breast volume were also investigated. The dosimetric error was evaluated for each dose plan by calculating the volume outside the 95-105% dose range resulting from the simulations. A number of parameters describing the size and shape of the breast were also investigated to determine whether a susceptibility of outline sets to interfractional patient movement could be predicted. A parameter describing the increase in the breast volume outside the 95-105% dose range was calculated for AP a
On the efficacy of fine-grained traffic splitting protocols in data center networks (2012)

Current multipath routing techniques split traffic at a per-flow level because, according to conventional wisdom, forwarding packets of a TCP flow along different paths leads to packet reordering which is detrimental to TCP. In this paper, we revisit this "myth" in the context of cloud data center networks which have regular topologies such as multi-rooted trees. We argue that due to the symmetry in the multiple equal-cost paths in such networks, simply spraying packets of a given flow among all equal-cost paths, leads to balanced queues across multiple paths, and consequently little packet reordering. Using a testbed comprising of NetFPGA switches, we show how cloud applications benefit from better network utilization in data centers.
A Condensing Enzyme from the Seeds of Lesquerella fendleri That Specifically Elongates Hydroxy Fatty Acids (2001)

Lesquerella fendleri seed oil contains up to 60% hydroxy fatty acids, nearly all of which is the 20-carbon hydroxy fatty acid lesquerolic acid (D-14-hydroxyeicos-cis-11-enoic acid). Previous work suggested that lesquerolic acid in L. fendleri was formed by the elongation of the 18-carbon hydroxy fatty acid, ricinoleic acid. To identify a gene encoding the enzyme involved in hydroxy fatty acid elongation, an L. fendleri genomic DNA library was screened using the coding region of the Arabidopsis Fatty Acid Elongation1 gene as a probe. A gene, LfKCS3, with a high sequence similarity to known very long-chain fatty acid condensing enzymes, was isolated. LfKCS3 has a 2,062-bp open reading frame interrupted by two introns, which encodes a polypeptide of 496 amino acids. LfKCS3 transcripts accumulated only in the embryos of L. fendleri and first appeared in the early stages of development. Fusion of the LfKCS3 promoter to the uidA reporter gene and expression in transgenic Arabidopsis resulted in a high level of beta-glucuronidase activity exclusively in developing embryos. Seeds of Arabidopsis plants transformed with LfKCS3 showed no change in their very long-chain fatty acid content. However, when these Arabidopsis plants were crossed with the transgenic plants expressing the castor oleate 12-hydroxylase, significant amounts of 20-carbon hydroxy fatty acids accumulated in the seed, indicating that the LfKCS3 condensing enzyme specifically catalyzes elongation of 18-carbon hydroxy fatty acids.
DESIGN, ANALYSIS, AND PERFORMANCE OF AN EXPERIMENTAL LIQUID HYDROGEN-WATER HEAT EXCHANGER (1966)

hydrogen-water h e a t exchanger was d e s i g n e d , b u i l t , and t e s t g d .