gebhart/patrepeval huggingface dataset:
Application of three aquifer test methods for estimating hydraulic properties within the 100-N Area (1992)

The purpose if this study was to better define the range of saturated horizontal hydraulic conductivities in the 100-N Area of the Hanford Site in southeastern Washington for use in a numerical groundwater model. Three methods were used for determining aquifer properties and are discussed within this report (1) reanalysis of past pumping test data using a pressure derivative method to identify the data in the radial flow regime for analysis by traditional graphical techniques, (2) sinusoidal analysis techniques described in Ferris that utilize water-table responses to river-level variations, and (3) the basic flow equation for groundwater.
APP promotes osteoblast survival and bone formation by regulating mitochondrial function and preventing oxidative stress (2018)

Amyloid precursor protein (APP) is ubiquitously expressed in various types of cells including bone cells. Mutations in App gene result in early-onset Alzheimer's disease (AD). However, little is known about its physiological function in bone homeostasis. Here, we provide evidence for APP's role in promoting bone formation. Mice that knocked out App gene (APP<sup>-/-</sup>) exhibit osteoporotic-like deficit, including reduced trabecular and cortical bone mass. Such a deficit is likely due in large to a decrease in osteoblast (OB)-mediated bone formation, as little change in bone resorption was detected in the mutant mice. Further mechanical studies of APP<sup>-/-</sup> OBs showed an impairment in mitochondrial function, accompanied with increased reactive oxygen species (ROS) and apoptosis. Intriguingly, these deficits, resemble to those in Tg2576 animal model of AD that expresses Swedish mutant APP (APPswe), were diminished by treatment with an anti-oxidant NAC (n-acetyl-l-cysteine), uncovering ROS as a critical underlying mechanism. Taken together, these results identify an unrecognized physiological function of APP in promoting OB survival and bone formation, implicate APPswe acting as a dominant negative factor, and reveal a potential clinical value of NAC in treatment of AD-associated osteoporotic deficits.
A unified graphical models framework for automated human embryo tracking in time lapse microscopy (2014)

Time lapse microscopy has emerged as an important modality for studying early human embryo development. Detection of certain events can provide insight into embryo health and fate. Embryo tracking is challenged by a high dimensional search space, weak features, outliers, occlusions, missing data, multiple interacting deformable targets, changing topology, and a weak motion model. We address these with a data driven approach that uses a rich set of discriminative image and geometric features and their spatiotemporal context. We pose the mitosis detection problem as augmented simultaneous segmentation and classification in a conditional random field framework that combines tracking based and tracking free elements. For 275 clinical image sequences we measured division events during the first 48 hours of embryo development to within 30 minutes resulting in an improvement of 24.2% over a tracking-based approach and a 35.7% improvement over a tracking-free approach, and more than an order of magnitude improvement over a traditional particle filter, demonstrating the success of our framework.
Effect of organic matter from various sources on yield and quality of plant on soils contaminated with heavy metals (2011)

Continuous civilization progress, growing level of industrialization, and urbanization cause that the contents of heavy metals in the environment is increasing with a risk of biota and groundwater contamination. The experiment was carried out in stoneware pots sank into the ground filled up with 56.4 kg of soil: Haplic Luvisols formed from loamy sand. The soil was mixed up with liquid form of salts: Cd(NO3)2, Pb(CH3COO)2 and ZnSO4. To the soil a brown coal preparation, so called “Rekulter”, brown coal, peat and farmyard manure were applied in the amount of 180, 140, 390 and 630 g per pot, which is equivalent to 5 Mg of organic carbon per ha. Winter rye (Secale cereale) was harvested in green forage. The manurial value of organic substance originated from different sources expressed as the plants' crop was the highest for Rekulter and the lowest for peat. The addition of organic substance to soil contaminated with heavy metals causes the higher content of phosphorus in rye's roots. The content of sodium in the rye's above grounds parts did not depend from addition of organic matter to soil. The contents of nitrogen in rye on contaminated soil were higher in comparison with plants from soil without heavy metals.
Genetic Diversity and Improvement of Bougainvillea (2021)

AbstractBougainvillea is a very important floriculture crop for multipurpose use. A good number of varieties have been developed in different parts of world/India through detection and isolation of bud sports, hybridization and induced mutation. All basic scientific information are available on different aspects of Bougainvillea. Considering its importance more work should be initiated for development of improved varieties through careful selective breeding. Conservation of genetic diversity of Bougainvillea is an important aspect. Breeding work may be initiated to develop more and more strains tolerant to climate change.
Contributions des transcriptomes du foie, tissu adipeux et muscle aux mécanismes d'adaptation des poulets de chair face à une variation de la source d'énergie dans l'aliment (2015)

Les tensions actuelles sur le marche des cereales conduisent a integrer des matieres premieres moins conventionnelles dans les
aliments des poulets de chair. Substituer l' amidon des cereales par des fibres completees par des lipides pour avoir un regime
isoenergetique est une alternative economiquement interessante mais qui doit etre evaluee. Afin de mesurer la capacite
d'adaptation du poulet de chair a ces variations de sources energetiques, 48 poulets mâles de lignees maigre ou grasse ont ete
nourris pendant 6 semaines avant abattage avec deux regimes isoenergetiques et isoproteiques, mais differant par leur teneur en
lipides (8% versus 2%) et en amidon (38% versus 51%) et notes respectivement HL et LL. Parce qu' il a ete montre que la
source en energie du regime n'a eu aucun effet sur les performances de croissance et la composition corporelle a 63 jours
d' âge, cette etude a pour objectif d' identifier les mecanismes genetiques impliques dans cette adaptation. Pour cela, nous avons
analyse sur ces memes poulets, les transcriptomes de trois tissus cles impliques dans le metabolisme energetique (foie, gras
abdominal et muscle) en utilisant une puce personnalisee permettant de mesurer l'expression de l' ensemble des genes
references chez la poule. Comme attendu, environ 70% des genes references sont exprimes dans chacun des trois tissus. En
revanche, seul le foie presente des genes differentiellement exprimes entre regimes. Au total, 388 et 199 genes sont sous- et
sur-exprimes respectivement avec le regime HL compare au regime LL correspondant a un regimt: standard. Une analyse
fonctionnelle de ces genes montre dans le regime HL une inhibition de l'expression de nombreux genes associes a la synthese
et au transport des acides gras (AG) et a la synthese du glycogene. On retrouve egalement reprimes les expressions des
regulateurs classiques de ces metabolismes que sont SREBPI et PPARgamma. A l'inverse, sont surexprimes avec le regime
HL des genes impliques dans le systeme de conversion des AG en acyl-camitine, indispensable a leur entree dans la
mitochondrie pour y etre ~-oxyde. Sont egalement surexprimes dans le regime HL des genes impliques dans la reponse
immunitaire, regulation qui pourrait etre en partie due a la faible expression des PPARs avec ce regime. De facon plus
surprenante, nous observons des variations d'expression pour des genes impliques dans le metabolisme du fer et de l'oxygene.
Ces resultats montrent le role central du foie dans l' adaptation des poulets face aux variations de sources energetiques
alimentaires.
Exploring the Relation Between Intramolecular Conjugation and Band Dispersion in One-Dimensional Polymers (2017)

Making use of the inherent surface anisotropy of different high index surface planes vicinal to the low index Au(111) orientation, one-dimensional polymers have been synthesized following established procedures from two different precursor molecules. The successful polymerization of both 4,4″-dibromo-p-terphenyl and 5,5′-dibromo-salophenato-Co(II) precursors into poly(p-phenylene) and poly[salophenato-Co(II)], respectively, has been confirmed by scanning tunneling microscopy and low energy electron diffraction. Angle-resolved photoemission spectroscopy data reveal a highly dispersive band in the case of poly(p-phenylene) while no significant dispersion is resolved for poly[salophenato-Co(II)]. On the basis of density functional theory calculations, we explain this observation as a result of a high conjugation along the aromatic phenyl groups in poly(p-phenylene) that is absent in the case of poly[salophenato-Co(II)], where intramolecular conjugation is interrupted in the salophenato-Co(II) unit. Furthermore, we make use of multicenter and delocalization indexes to characterize the electron mobility (corresponding to a high band dispersion) along different paths associated with individual molecular orbitals.
Visible diode laser induced fluorescence detection in liquid chromatography after precolumn derivatization of thiols (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVisible diode laser induced fluorescence detection in liquid chromatography after precolumn derivatization of thiolsArjan J. G. Mank, Ernst J. Molenaar, Henk. Lingeman, Cees. Gooijer, Udo A. T. Brinkman, and Nel H. VelthorstCite this: Anal. Chem. 1993, 65, 17, 2197–2203Publication Date (Print):September 1, 1993Publication History Published online1 May 2002Published inissue 1 September 1993https://pubs.acs.org/doi/10.1021/ac00065a006https://doi.org/10.1021/ac00065a006research-articleACS PublicationsRequest reuse permissionsArticle Views188Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Laser Welding of Navy Ship Construction Materials (1973)

Abstract : An experimental investigation was conducted of laser welding of Navy ship construction materials. Bead-on-plate penetrations were formed in 1/4-in.- thick HY-130 steel, 1/16-in.-thick HY-180 steel, 1/8- and 1/4-in.-thick Ti-6Al- 4V titanium alloy and in 1/8-in.-thick 5456 aluminum alloy. Continuous carbon- dioxide laser power levels to 8 kW were used; welding speed was varied from 20 to 180 ipm in order to establish appropriate welding parameters. The bead-on- plate penetrations were initially screened by visual, metallographic, NDT and mechanical tests and then forwarded to NSSC for more detailed evaluation. The finished samples, which were 5 x 7 in. in size, exhibited excellent top and bottom surface bead characteristics and defect-free fusion zones.
REDUCING THE ECONOMIC RISK OF ANIMAL HUSBANDRY BY ADAPTING ACQUISITION STRATEGIES FOR OPTIMAL FEED COMMODITY (2007)

Among the costs of animal husbandry – regardless of the animal species in question– the most significant is that for feed. Among the different crop years, we can noticegreat divergences in the prices of seed feeds. This phenomenon is associated withsignificant seasonal factors in each year. These prices and yield fluctuationsincrease notably the economic risk to animal husbandry. In the course of ourresearch, we adapted and developed deterministic inventory models to createdifferent acquisition strategies. For us the most appropriate choice among thepossible strategies is that which is secured by maximum income, combined withalternative investment possibilities.
SOLUBLE COMPONENTS OF UTAH VALLEY PARTICULATE POLLUTION ALTER ALVEOLAR MACROPHAGE FUNCTION IN VIVO AND IN VITRO (2000)

Water-soluble extracts of Utah Valley dust (UVD) have been found to cause inflammatory injury of the lung in both humans and rodents. The degree of lung damage found correlated with the metal content in the extracts. In the present study, extracts of a set of UVD PM(10) filters collected over a 3-yr span, varying in total metal content with yr 1 = yr 3 > yr 2, were used to assess effects on human alveolar macrophage (AM) function. The phagocytic activity and oxidative response of AM was investigated 24 h after segmental instillation of UVD, or after overnight in vitro culture of the extracts with AM. Using flow cytometry analysis, AM phagocytosis of fluorescently (FITC)-labeled Saccharomyces cerevisiae was inhibited following instillation of UVD1 (61%) but not by yr 2 and 3. Neither baseline oxidant activity nor phorbol ester-induced oxidant generation was affected by the dust extracts in vivo. Overnight culture of AM with UVD1 resulted in a significant decrease in the percentage of AM phagocytizing particles (30%), while no significant effect on this function was found with the other two extracts. Furthermore, only UVD1 caused an immediate oxidative response in AM, although both UVD1 and UVD3 inhibited oxidant activity in AM when the cells were incubated with the extracts overnight. The detrimental effects on AM host defenses could be due to apoptosis, which was evident in cells exposed to the UVD1 and to a much lesser extent with AM exposed to yr 2 and 3. The component(s) responsible for the toxic effects on AM in vitro were removed by pretreatment of the UVD extracts with a polycation chelating resin, chelex-100. However, since yr 1 and 3 are similar in their soluble metal content, but differ in their effects on AM phagocytosis, it is possible that the metals may not be the culprit in effects of particulate matter on AM host defense.
Effect of Glyphosate on Introduced and Native Grasses (1991)

The effect of glyphosate applied alone and with 2,4-D as a commercial mixture on 30 native or introduced grass species was evaluated. Grass yield averaged 98 and 87% of the untreated controls when glyphosate was applied in the fall at 0.2 or 0.4 kg ae ha -1 , respectively, alone or with 2,4-D at 0.35 or 0.7 kg ae ha -1 . Western wheatgrass production decreased more than any other species present in a native rangeland site following either a spring or fall glyphosate application. In seeded plots, intermediate wheatgrass was the most and ‘Fairway’ crested wheatgrass the least susceptible to glyphosate plus 2,4-D with average yields of 57 and 97% compared with untreated controls of each species, respectively. Glyphosate reduced the yield of ‘Nordan’ standard crested wheatgrass more than that of Fairway crested wheatgrass or other diploid cultivars. The greater the spring precipitation following a fall application of glyphosate, the less effect of glyphosate on forage yield. Glyphosate plus 2,4-D can be used for weed control in pasture and rangeland provided some yield reduction is acceptable.
ULSI DRAM technology with Ba/sub 0.7/Sr/sub 0.3/TiO/sub 3/ film of 1.3nm equivalent SiO/sub 2/ thickness and 10/sup -9/ A/cm/sup 2/ leakage current (1992)

A high-dielectric constant material have received increasing attention in view of an application to ULSI DRAMs for keeping a simple cell structure. We demonstrate a new technology with a planar-type single stacked structure utilizing a high-dielectric constant film of Ba/sub 1-x/Sr/sub x/TiO/sub 3/ (BST). The fabricated memory cell capacitor shows a low leakage current of 2*10/sup -9/ A/cm/sup 2/ under an applied voltage of 3.3V and a large capacitance of 32fF/um/sup 2/, which means that the BST film is equivalently as thin as 1.3nm of SiO/sub 2/.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Development and Validation of Machine Models Using Natural Language Processing to Classify Substances Involved in Overdose Deaths (2022)

In this diagnostic study, NLP/ML algorithms demonstrated excellent diagnostic performance at classifying substances related to overdoses. These algorithms should be integrated into workflows to decrease the lag time in reporting overdose surveillance data.
Survey of 3d image segmentation methods (2022)

This report reviews selected image binarization and segmentation methods that have been proposed and which are suitable for the processing of volume images.The focus is on thresholding, region growing, and shape-based methods.Rather than trying to give a complete overview of the field, we review the original ideas and concepts of selected methods, because we believe this information to be important for judging when and under what circumstances a segmentation algorithm can be expected to work properly.
Le formage électromagnétique des métaux liquides - Aspects expérimentaux et théoriques (1982)

The possibility of imposing a given shape to a liquid metal column or to guide it without contact with walls, by using high frequency alternating magnetic fields is proved both experimentally and theoretically.Two types of inductor are tested on an experimental setup using the mercury as the test metal. The first, able to impose a cross shape as cross section of an initially circular mercury vein, may also act as a guide. The second, also tested on molten tin, stretches a circular vein in the form of a sheet.The free boundary problem regarding the theoretical prediction of the forms of equilibrium is analyzed. The calculation is based on the exploitation of complex potentials and conformal mapping used alone in the case of pure magnetic balance and in combination with energy variational methods when additional constrain (eg surface tension) is involved.
A Research Agenda for Precision Medicine in Sepsis and Acute Respiratory Distress Syndrome: An Official American Thoracic Society Research Statement (2021)

<b>Background:</b> Precision medicine focuses on the identification of therapeutic strategies that are effective for a group of patients based on similar unifying characteristics. The recent success of precision medicine in non-critical care settings has resulted from the confluence of large clinical and biospecimen repositories, innovative bioinformatics, and novel trial designs. Similar advances for precision medicine in sepsis and in the acute respiratory distress syndrome (ARDS) are possible but will require further investigation and significant investment in infrastructure. <b>Methods:</b> This project was funded by the American Thoracic Society Board of Directors. A multidisciplinary and diverse working group reviewed the available literature, established a conceptual framework, and iteratively developed recommendations for the Precision Medicine Research Agenda for Sepsis and ARDS. <b>Results:</b> The following six priority recommendations were developed by the working group: <i>1</i>) the creation of large richly phenotyped and harmonized knowledge networks of clinical, imaging, and multianalyte molecular data for sepsis and ARDS; <i>2</i>) the implementation of novel trial designs, including adaptive designs, and embedding trial procedures in the electronic health record; <i>3</i>) continued innovation in the data science and engineering methods required to identify heterogeneity of treatment effect; <i>4</i>) further development of the tools necessary for the real-time application of precision medicine approaches; <i>5</i>) work to ensure that precision medicine strategies are applicable and available to a broad range of patients varying across differing racial, ethnic, socioeconomic, and demographic groups; and <i>6</i>) the securement and maintenance of adequate and sustainable funding for precision medicine efforts. <b>Conclusions:</b> Precision medicine approaches that incorporate variability in genomic, biologic, and environmental factors may provide a path forward for better individualizing the delivery of therapies and improving care for patients with sepsis and ARDS.
Supplemental Figure 3 from Combined TRAF6 Targeting and Proteasome Blockade Has Anti-myeloma and Anti-Bone Resorptive Effects (2023)

&lt;p&gt;Evaluation of AKT signaling pathway in primary MM cells treated with a TRAF6dn inhibitory peptide.&lt;/p&gt;
DICOM Structured Reporting (2004)

Structured reporting (SR) was recently added to the Digital Imaging and Communications in Medicine (DICOM) standard to provide an efficient mechanism for the generation, distribution, and management of clinical reports. The main advantage of SR is the ability to link clinical documents with the referenced images for simultaneous retrieval and display. A generic SR toolkit that covers the different clinical reports used in today's healthcare enterprises was developed for picture archiving and communication system (PACS) workstations. The modules of the SR toolkit collaborate to automatically construct the DICOM SR files from the free-text input presented in hypertext markup language (HTML) by using the associated SR trees. The DICOM toolkit is reused for SR encoding and DICOM services. A setup module was required for creating both the standard and private SR templates used in different healthcare specialties. The SR manager transparently converts between the different SR document presentations, that is, DICOM SR files and HTML documents, to provide the end users with an easy-to-use toolkit. To evaluate and demonstrate the effectiveness of the SR toolkit in a pragmatic setting, the toolkit was integrated into PACS workstations.
Alternate Deposition of Cationic and Anionic Polymers for the Improvement of Response Characteristics of Glucose Biosensor (1999)

Organic thin films composed of cationic and anionic polymers were prepared on the surface of glucose biosensor by an alternate deposition technique, to improve the response characteristics of the biosensor. The polymer thin film significantly suppressed the permeation of both glucose and ascorbic acid, which resulted in a suppression of ascorbate interference or an improvement of the dynamic range, depending on the arrangement of the enzyme and polymer layers on the electrode surface.
Pacemaker Wire Central Venous Stenosis and One More Reason to Not Run Central Venous Catheters for Dialysis in Reverse Flow (2012)

A 75-year-old man on chronic peritoneal dialysis had unrecognized stenosis of the superior vena cava (SVC) due to pacemaker wires placed 5 years earlier. The patient was placed on hemodialysis after hernia surgery. When a tunneled central venous catheter for dialysis was placed from the right internal jugular (IJ) vein, the venous lumen extended through the stenotic area but not the arterial lumen. Probably due to a subsequent clot at the arterial lumen port the patient developed SVC syndrome and when the catheter was run in the reversed flow direction he developed hypovolemic shock. The stenosis and SVC syndrome resolved with angioplasty of the SVC stenosis, removal of the IJ catheter and use of a femoral vein catheter. The patient eventually returned to peritoneal dialysis and the femoral catheter was removed.