gebhart/patrepeval huggingface dataset:
Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye (2015)

The mechanical characteristics of the trabecular meshwork (TM) are linked to outflow resistance and intraocular pressure (IOP) regulation. The rationale behind this technique is the direct observation of the mechanical response of the TM to acute IOP elevation. Prior to scanning, IOP is measured at baseline and during IOP elevation. The limbus is scanned by spectral-domain optical coherence tomography at baseline and during IOP elevation (ophthalmodynamometer (ODM) applied at 30 g force). Scans are processed to enhance visualization of the aqueous humor outflow pathway using ImageJ. Vascular landmarks are used to identify corresponding locations in baseline and IOP elevation scan volumes. Schlemm canal (SC) cross-sectional area (SC-CSA) and SC length from anterior to posterior along its long axis are measured manually at 10 locations within a 1 mm segment of SC. Mean inner to outer wall distance (short axis length) is calculated as the area of SC divided by its long axis length. To examine the contribution of adjacent tissues to the effect IOP elevations, measurements are repeated without and with smooth muscle relaxation with instillation of tropicamide. TM migration into SC is resisted by TM stiffness, but is enhanced by the support of its attachment to adjacent smooth muscle within the ciliary body. This technique is the first to measure the living human TM response to pressure elevation in situ under physiological conditions within the human eye.
Erythrocyte n-6 Fatty Acids and Risk for Cardiovascular Outcomes and Total Mortality in the Framingham Heart Study (2018)

Higher circulating levels of marine n-3 FA levels are associated with reduced risk for incident CVD and ischemic stroke and for death from CHD and all-causes; however, in the same sample little evidence exists for association with n-6 FAs. Further work is needed to identify a full profile of FAs associated with cardiovascular risk and mortality.
Evolutionary engineering of multiple-stress resistant (2004)

Various selection procedures in chemostats and batch cultures were systematically tested for their efficiency to select for a multiple-stress resistance phenotype in Saccharomyces cerevisiae. To determine the relative stress resistance phenotypes, mutant populations harvested at different time points and randomly chosen clones from selected populations were grown in batch cultures and exposed to oxidative, freezing-thawing, high-temperature and ethanol stress. For this purpose, we developed a high-throughput procedure in 96-well plates combined with a most-probable-number assay. Among all chemostat and batch selection strategies tested, the best selection strategy to obtain highly improved multiple-stress-resistant yeast was found to be batch selection for freezing-thawing stress. The final mutant populations selected for this particular stress were not only significantly improved in freezing-thawing stress resistance, but also in other stress resistances. The best isolated clone from these populations exhibited 102-, 89-, 62-, and 1429-fold increased resistance to freezing-thawing, temperature, ethanol, and oxidative stress, respectively. General selection guidelines for improving multiple-stress resistance in S. cerevisiae are presented and discussed.
Direct Catalytic Asymmetric Aldol Reaction of an α‐Azido Amide (2015)

A direct aldol reaction of an α-azido 7-azaindolinylamide, promoted by a Cu-based cooperative catalyst, is documented. Aromatic aldehydes bearing an ortho substituent exhibited diastereodivergency depending on the nature of the chiral ligands used. Smooth reactions with ynals highlighted the broad substrate scope. A vicinal azido alcohol unit in the product allowed direct access to the corresponding aziridine and facile hydrolysis of the 7-azaindolinylamide moiety furnished enantioenriched β-hydroxy-α-azido carboxylic acid derivatives.
Cascade Diffusion Theory of Displacement-Induced Point Defect Concentration and Flux Fluctuations (1987)

A theoretical approach, which has been developed to assess the fluctuations in point defect concentrations and fluxes to sinks that are induced by the production of point defects in spatially and temporally discrete cascades, is summarized. Solutions for cascade dissipation are outlined for the case where cascades occur in a homogeneous lossy medium as well as for the more involved geometries where cascades occur in the presence of a nearby dislocation or cavity. By superposition of solutions representing discrete cascades under conditions of interest, time profiles of point defect concentrations and fluxes are generated. The profiles exhibit extreme fluctuations. Continuum rate theory results arise by applying limits and approximations to cascade diffusion theory. Application of the theory to microstructural processes shows that property changes, especially creep are affected by the fluctuations.
Ranking Deep Web Text Collections for Scalable Information Extraction (2015)

Information extraction (IE) systems discover structured information from natural language text, to enable much richer querying and data mining than possible directly over the unstructured text. Unfortunately, IE is generally a computationally expensive process, and hence improving its efficiency, so that it scales over large volumes of text, is of critical importance. State-of-the-art approaches for scaling the IE process focus on one text collection at a time. These approaches prioritize the extraction effort by learning keyword queries to identify the "useful" documents for the IE task at hand, namely, those that lead to the extraction of structured "tuples." These approaches, however, do not attempt to predict which text collections are useful for the IE task---and hence merit further processing---and which ones will not contribute any useful output---and hence should be ignored altogether, for efficiency. In this paper, we focus on an especially valuable family of text sources, the so-called deep web collections, whose (remote) contents are only accessible via querying. Specifically, we introduce and study techniques for ranking deep web collections for an IE task, to prioritize the extraction effort by focusing on collections with substantial numbers of useful documents for the task. We study both (adaptations of) state-of-the-art resource selection strategies for distributed information retrieval, and IE-specific approaches. Our extensive experimental evaluation over realistic deep web collections, and for several different IE tasks, shows the merits and limitations of the alternative families of approaches, and provides a roadmap for addressing this critically important building block for efficient, scalable information extraction.
Fuzzy Orders-of-Magnitude-Based Link Analysis for Qualitative Alias Detection (2011)

Alias detection has been the significant subject being extensively studied for several domain applications, especially intelligence data analysis. Many preliminary methods rely on text-based measures, which are ineffective with false descriptions of terrorists' name, date-of-birth, and address. This barrier may be overcome through link information presented in relationships among objects of interests. Several numerical link-based similarity techniques have proven effective for identifying similar objects in the Internet and publication domains. However, as a result of exceptional cases with unduly high measure, these methods usually generate inaccurate similarity descriptions. Yet, they are either computationally inefficient or ineffective for alias detection with a single-property based model. This paper presents a novel orders-of-magnitude based similarity measure that integrates multiple link properties to refine the estimation process and derive semantic-rich similarity descriptions. The approach is based on order-of-magnitude reasoning with which the theory of fuzzy set is blended to provide quantitative semantics of descriptors and their unambiguous mathematical manipulation. With such explanatory formalism, analysts can validate the generated results and partly resolve the problem of false positives. It also allows coherent interpretation and communication within a decision-making group, using this computing-with-word capability. Its performance is evaluated over a terrorism-related data set, with further generalization over publication and email data collections.
Supplementary Figure S3 from Potent Antimyeloma Activity of a Novel ERK5/CDK Inhibitor (2023)

&lt;p&gt;Survival evaluation of mice treated with TG02 and its combinations with lenalidomide and bortezomib, and weight data corresponding to this in vivo assay.&lt;/p&gt;
The Defibrillation Threshold: A Comparison of Anesthetics and Measurement Methods (1993)

In 18 open-chested mongrel dogs (18.0 +/- 1.7 kg) we compared three anesthetics and three methods for measuring the defibrillation threshold. Six animals were anesthetized with pentobarbital (30 mg/kg) and maintained with a pentobarbital infusion (4 mg/kg per hour). All other animals were anesthetized with sodium brevital (10 mg/kg) and maintained with either halothane gas (1.5%, N = 6) or isoflurane gas (1.8%, N = 6). In each dog, we measured the energy required for 50% successful defibrillation (E50) with: (A) a 3 reversal--up/down method; (B) a 15 shock--up/down method; and (C) a percent success method. Anesthetics and methods were selected in a balanced random order. Ventricular fibrillation was induced with 50 Hz electrical pacing. After 15 seconds, monophasic truncated exponential shocks were delivered by way of a spring-patch electrode configuration. The animal was rescued (if needed) and fibrillation/defibrillation episodes were repeated at 3 minute intervals. After each determination of the E50, the E50 was delivered in ten successive defibrillation trials to determine its actual success rate. We found no significant difference in E50 among anesthetics; a significant difference (P < 0.05) in E50 between method C (9.7 +/- 2.6 joules) and method B (8.2 +/- 1.6 joules); no significant difference among anesthetics or methods for the actual success rate of the E50 (45 +/- 21% successful); and method A required significantly fewer fibrillation episodes and number of shocks and less cumulative energy than the other methods. We concluded that the anesthetics tested had little effect on E50 but that the method used to determine E50 could have an effect.(ABSTRACT TRUNCATED AT 250 WORDS)
Electrical resistance of individual defects at a topological insulator surface (2017)

Three-dimensional topological insulators host surface states with linear dispersion, which manifest as a Dirac cone. Nanoscale transport measurements provide direct access to the transport properties of the Dirac cone in real space and allow the detailed investigation of charge carrier scattering. Here we use scanning tunnelling potentiometry to analyse the resistance of different kinds of defects at the surface of a (Bi<sub>0.53</sub>Sb<sub>0.47</sub>)<sub>2</sub>Te<sub>3</sub> topological insulator thin film. We find the largest localized voltage drop to be located at domain boundaries in the topological insulator film, with a resistivity about four times higher than that of a step edge. Furthermore, we resolve resistivity dipoles located around nanoscale voids in the sample surface. The influence of such defects on the resistance of the topological surface state is analysed by means of a resistor network model. The effect resulting from the voids is found to be small compared with the other defects.
Real-Time Power Management for Microgrids With Dynamic Boundaries and Multiple Source Locations (2022)

The dynamic boundary concept enables more flexible and efficient operation of microgrids with distributed energy resources (DER) that are intermittent in nature. As the integration of renewables continues to accelerate, an adaptive power management module that enables dynamic boundary operations in microgrids with an increasing number of source locations is essential for the fast and low-cost deployment of microgrid controllers. The power management module introduced in this paper is capable of handling the increased complexity in topological variations and transitions stemming from the dynamic boundaries and multiple source locations. This includes real-time operation of multiple islands with dynamic boundaries, initiation of topological transitions (merging and separation of islands), and automatic source coordination for power sharing and frequency regulation. All functions in the power management module are designed to be automatically adaptable to arbitrary microgrids with non-meshed topologies so that the deployment of the controller at new microgrid sites can be expedited with a reduced cost. The module has been implemented on NI&#x2019;s CompactRIO system as an essential part of an MG controller and tested on a converter-based hardware testbed (HTB). Testing results validated the effectiveness of the algorithms under various operating conditions.
Partial compliance with antipsychotics increases mental health hospitalizations in schizophrenic patients: analysis of a national managed care database. (2009)

Small decreases in compliance with antipsychotics are associated with increased hospitalization risk among patients with schizophrenia in a managed care population.
Increase in Skin Temperature After Spinal Anesthesia in Infants (2006)

The authors found a significant increase in skin temperature of the feet within 10 minutes as a sign of sympatholysis, whereas trunk temperature remained constant. Blood pressure decreased but remained within the normal range, despite the observed sympatholysis.
Three-level buck converter for envelope tracking applications (2006)

This letter proposes a three-level buck converter for tracking applications such as envelope-tracking in radio frequency power amplifiers (RFPAs). It is shown that the three-level buck converter can offer advantages in terms of switching ripples, losses, bandwidth, or the size of magnetic components compared to a standard buck or a two-phase buck converter. Experimental results illustrate improved efficiency and ripple rejection in an RFPA envelope-tracking application representative for low-power battery-operated systems.
Transformation of Amorphous Calcium Carbonate in Air (2016)

In air, the mechanisms of amorphous calcium carbonate (ACC) transformation into crystalline polymorphs of CaCO3 and whether the atomic ordering is attributable to a solid-state transformation or a dissolution and reprecipitation process are still under debate. While some studies observed a significant influence of relative humidity on ACC transformation, other studies suggested a dehydration process of ACC prior to crystallization. In the present study, we focus on the metastability of additive-free ACC in air and in particular on its interaction with relative humidity. Our findings indicate that the transformation of ACC into crystalline CaCO3 is triggered only after the physisorption of a critical H2O level. Consequently, ACC metastability was prolonged by retarding H2O uptake and by keeping the physisorbed H2O below the critical level, ACC remained in its metastable state. Therefore, the conceptual formation of a “thin film” of about four monolayers of physisorbed H2O is considered to govern the transformation of ∼90 nm sized ACC particles via partial dissolution and reprecipitation. Furthermore, we observed simultaneous formation of calcite, vaterite, and aragonite from ACC, where distinct proportions correspond to different H2O exposure conditions. Thus, polymorph formation from ACC depends also on physicochemical boundary conditions during transformation rather than on prestructural formation within ACC alone.
Asymmetric Cation‐Olefin Monocyclization by Engineered Squalene–Hopene Cyclases (2021)

Abstract Squalene–hopene cyclases (SHCs) have great potential for the industrial synthesis of enantiopure cyclic terpenoids. A limitation of SHC catalysis has been the enzymes’ strict (S)‐enantioselectivity at the stereocenter formed after the first cyclization step. To gain enantio‐complementary access to valuable monocyclic terpenoids, an SHC‐wild‐type library including 18 novel homologs was set up. A previously not described SHC ( Aci SHC) was found to synthesize small amounts of monocyclic (R)‐γ‐dihydroionone from (E/Z)‐geranylacetone. Using enzyme and process optimization, the conversion to the desired product was increased to 79 %. Notably, analyzed Aci SHC variants could finely differentiate between the geometric geranylacetone isomers: While the (Z)‐isomer yielded the desired monocyclic (R)‐γ‐dihydroionone (&gt;99 % ee ), the (E)‐isomer was converted to the (S,S)‐bicyclic ether (&gt;95 % ee ). Applying the knowledge gained from the observed stereodivergent and enantioselective transformations to an additional SHC‐substrate pair, access to the complementary (S)‐γ‐dihydroionone (&gt;99.9 % ee ) could be obtained.
Kontrollierte Abschreckung von Aluminiumbauteilen durch Sprühkühlen (2013)

Kurzfassung Die Ausscheidungshärtung von Aluminium-Legierungen erfolgt durch eine Wärmebehandlung, bei der sich insbesondere der integrierte Abschreckprozess entscheidend auf die resultierenden Festigkeits- und Verzugseigenschaften des Bauteils auswirkt. Zur Einstellung höchster Festigkeiten ist eine hohe Abschreckgeschwindigkeit nach dem Lösungsglühen erforderlich, gleichzeitig besteht die Forderung nach einem lokal gleichmäßigen Abkühlverlauf, um Bauteilverzug zu vermeiden. Ein kontrollierter Abschreckvorgang bei der Wärmebehandlung von Aluminium-Bauteilen kann in flexiblen Sprühdüsenfeldern realisiert werden. Auf Basis von Abschreckprozesssimulationen können geeignete Wärmeübergänge ermittelt werden, die für die Auslegung von angepassten Sprühdüsenfeldern genutzt werden. Die Abschreckintensität kann dabei an die Bauteilgeometrie und die Abschreckempfindlichkeit der Legierung angepasst werden, um gezielt die mechanischen Eigenschaften und gleichzeitig den Verzug nach der Wärmebehandlung zu kontrollieren. Mit dem Ziel der Verzugsminimierung können so insbesondere durch den Einsatz von Zweistoffzerstäubern in Sprühkühlprozessen spezifische lokale Wärmeübergangsbedingungen eingestellt werden, die die Möglichkeit einer asymmetrischen Abschreckung von komplexen Aluminium-Bauteilen eröffnen. Ein flexibles Sprühdüsenfeld wurde in den Wärmebehandlungsprozess zur Ausscheidungshärtung von Knet-, Guss- und sprühkompaktierten Al-Legierungen integriert. In Abhängigkeit der Verfahrensparameter der flüssigen und der gasförmigen Phase des Sprays wurden mechanische Eigenschaften an zylindrischen Halbzeugen bestimmt. Diese Ergebnisse wurden auf Bauteile übertragen, an denen die Abschreckverläufe durch ein kontrolliert asymmetrisches Abschrecken an die Bauteilgeometrie angepasst werden.
Impedance of a Disk Electrode with Reactions Involving an Adsorbed Intermediate: Local and Global Analysis (2008)

International audience
Trichothecenes, 1: The Synthesis of 4-Deoxyverrucarol from Verrucarol and Diacetoxyscirpenol (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTrichothecenes, 1: The Synthesis of 4-Deoxyverrucarol from Verrucarol and DiacetoxyscirpenolPaul Francis Schuda, Steven J. Potlock, and Robert W. Wannemacher Jr.Cite this: J. Nat. Prod. 1984, 47, 3, 514–519Publication Date (Print):May 1, 1984Publication History Published online1 July 2004Published inissue 1 May 1984https://doi.org/10.1021/np50033a019RIGHTS & PERMISSIONSArticle Views90Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (384 KB) Get e-Alerts Get e-Alerts
High Resolution Mass Spectra of Compounds Separated by Capillary Columns. Use of a Plate Scan Technique. (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHigh Resolution Mass Spectra of Compounds Separated by Capillary Columns. Use of a Plate Scan Technique.Dieter. HennebergCite this: Anal. Chem. 1966, 38, 3, 495–496Publication Date (Print):March 1, 1966Publication History Published online1 May 2002Published inissue 1 March 1966https://pubs.acs.org/doi/10.1021/ac60235a033https://doi.org/10.1021/ac60235a033research-articleACS PublicationsRequest reuse permissionsArticle Views16Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Systems Genetic Analysis of Osteoblast-Lineage Cells (2020)

The osteoblast-lineage consists of cells at various stages of maturation that are essential for skeletal development, growth, and maintenance. Over the past decade, many of the signaling cascades that regulate this lineage have been elucidated; however, little is known of the networks that coordinate, modulate, and transmit these signals. Here, we identify a gene network specific to the osteoblast-lineage through the reconstruction of a bone co-expression network using microarray profiles collected on 96 Hybrid Mouse Diversity Panel (HMDP) inbred strains. Of the 21 modules that comprised the bone network, module 9 (M9) contained genes that were highly correlated with prototypical osteoblast maker genes and were more highly expressed in osteoblasts relative to other bone cells. In addition, the M9 contained many of the key genes that define the osteoblast-lineage, which together suggested that it was specific to this lineage. To use the M9 to identify novel osteoblast genes and highlight its biological relevance, we knocked-down the expression of its two most connected “hub” genes, Maged1 and Pard6g. Their perturbation altered both osteoblast proliferation and differentiation. Furthermore, we demonstrated the mice deficient in Maged1 had decreased bone mineral density (BMD). It was also discovered that a local expression quantitative trait locus (eQTL) regulating the Wnt signaling antagonist Sfrp1 was a key driver of the M9. We also show that the M9 is associated with BMD in the HMDP and is enriched for genes implicated in the regulation of human BMD through genome-wide association studies. In conclusion, we have identified a physiologically relevant gene network and used it to discover novel genes and regulatory mechanisms involved in the function of osteoblast-lineage cells. Our results highlight the power of harnessing natural genetic variation to generate co-expression networks that can be used to gain insight into the function of specific cell-types.