gebhart/patrepeval huggingface dataset:
Nature of T lymphocyte recognition of macrophage-associated antigens. V. Contribution of individual peptide residues of human fibrinopeptide B to T lymphocyte responses. (1980)

Guinea pig T lymphocyte responses to a decapeptide antigen (NH1-Asp5-Ans6-Glu7-Glu8-Gly9-Phe10-Phe11-Ser12-Ala13-Arg14-OH) of human fibrinopeptide B (hFPB) were examined using various synthetic peptide analogues containing single residue substitutions. Each analogue was examined for antigenicity as determined by an in vitro proliferative responses of hFPN-immune strain 2 guinae pig T cells. In addition, both strain 2 and strain 13 animals were immunized with each analogue and immunogenicity assessed by in vitro T cell-proliferative responses with the homologous immunizing analogue and the parent peptide. Replacement of arginine14 with lysine formed an immunogenic analogue which showed no antigenic cross-reactivity with the native peptide in strain 2 T cell responses. In addition, substitution of arginine14 with blocked lysine again produced a unique immunogenic analogue that showed little or no antigenic identity with the intact lysine analogue or the native peptide. In similar fashion, substitution of resideu phenylalanie10 with tyrosine or Phe(4-NO2) created unique immunogenic analogues with little or no antigenic identity to the native peptide with strain 2 T cells. By contrast, replacement of phenylalanine11 with either tyrosine or Phe(4-NO2) resulted in analogues with a total loss of immunogenicity and antigenicity in strain 2 T cell responses. An analogue in which glutamic acid7,8 were replaced with glutamine retained a small degree of antigenicity with hFPB-immune T cells, but T cells from strain 2 animals immunized with the Gln analogue responded only marginally to the Gln analogue while producing good proliferative responses with the native peptide. On the other hand, an analogue in which asparatic acid5 was replaced with asparagine retained most of the antigenic identity with hFPB for strain 2 T cell responses. None of thee analogues were immunogenic for strain 13 guinea pigs. These observations are discussed with respect to the contribution of each substituted residue to T cell respones, mechanism of Ir gene function, and a model for T cell recognition of small peptide antigens.
Polímeros hiperramificados : síntesis, propiedades y aplicaciones (2006)

Las aplicaciones basadas en polimeros hiperramificados han crecido exponencialmente en los ultimos anos, ya que su alta funcionalidad permite el desarrollo de nuevos productos, con una gran variedad de arquitecturas moleculares y aplicaciones. Estas caracteristicas, junto al hecho de que su sintesis se realice en un solo paso, hacen que estos polimeros se contemplen como una alternativa economica y viable a los dendrimeros. La modificacion de los grupos terminales de los polimeros hiperramificados permite variar algunas de sus propiedades, tales como la temperatura de transicion vitrea, la solubilidad y la viscosidad, del mismo modo que determina muchas de sus posibles aplicaciones. Estas aplicaciones van desde aditivos para recubrimientos hasta las mas avanzadas tecnologias como los sensores.
Characteristics of hetero-core spliced fiber optics in simultaneous utilization of humidity sensing and data communications (2009)

We aim at composing a novel remote monitoring system of the water level and soil humidity under the natural environment with a hetero-core spliced fiber optic chemical sensor inserted into an existing communication line. This paper demonstrates the fusion characteristics of an optical communications and a humidity sensing by means of a hetero-core spliced fiber optic sensor that has been highly-vaunted from the practical perspective. However, this humidity sensor leaks light and attenuates the optical signal power of a communication wavelength by intent on sensing use. From the communications standpoint, this may lead to decrease intensity of optical signals sent to the receiver and increase a bit error. In other words, there may be a trade-off relationship between communications quality and measuring accuracy. We have proved the possibility of the co-existence of communication signals and measuring functions by finding out the effect of humidity sensing on the communications is the optical loss and modal dispersion.
Modelización 3D combinando los "software" gOcad y gOsed en dos sistemas turbidíticos del Grupo de Hecho: sistemas Banastón y Morillo (cuenca eocena surpirenaica central) (2004)

Classical facies models derived from outcrop studies are generally focused on depositional processes 
and generally don't link precisely the lateral variability of facies with the internal 3D architecture of 
sandy reservoirs. Facies are still commonly described independently from 3D seismic architecture in 
a stamp like collection approach. As a consequence the reserarch program sponsored by Total aimed 
to the study of the Ainsa basin outcrops to represent and understand the 3D geometrical architecture 
of the infill of several channelised turbidite reservoirs in relation with lateral facies variability. The 
work is particularly focused on the Banaston, Ainsa and Morillo turbidite systems, with the examples 
here repported taking the Banaston and the Morillo System. The architectural model was built using 
the gOsed software within the gOcad software modelling environment. 
The final product is a field scale continuous gridded model with various size cells, which can be 
compared with the real small-scale geological observations made on the field. Outcrop geology 
can be compared with the coarse grid numerical model using 3D numerical orthophotos. The 
sedimentary modelling of the Ainsa basin provides a unique 3D model allowing interactive field 
trips for sedimentologist, reservoir engineers and geophysicists.
Packet data access in DECT systems (2002)

The emerging demand for cordless LANs can be satisfied by the adoption of DECT (Digital European Cordless Telecommunication) standard because of its high flexibility, high capacity, and interoperability with many backbone networks. Packet data applications need fast channel selection procedures, but the dynamic channel selection algorithm, supported by DECT, is optimized for voice calls, operating in the circuit mode, where relatively long setup times are acceptable. For this reason, we discuss the inefficiency of the DECT standard access for short messages and we propose an enhanced dynamic channel selection algorithm that allows one to reduce the access delay. The performance analysis, based on computer simulation, is also given for an integrated services scenario, where both algorithms are maintained.
Chronic administration of aminoguanidine improves function of cardiovascular system in rats with monocrotaline-induced pulmonary hypertension (2002)

Monocrotaline (MCT)-induced pulmonary hypertension (PH) is associated with impaired NO-mediated relaxation and increased activity of inducible NO-synthase (iNOS). Overproduction of NO can damage the NO-dependent vasodilatation in pulmonary and systemic vessels. To examine a role of iNOS in MCT-induced PH, we used an iNOS inhibitor - aminoguanidine (AG). PH was modeled by subcutaneous injection of 60 mg/kg MCT to Wistar rats (MCT-rats); control rats were injected by saline (C-rats). Then each group was separated to 2 sub-groups: 1-st was given drinking water (MCT-C and C-C groups) and the 2-nd was given AG in drinking water (15 mg/(kg-1·day-1)) (MCT-AG and C-AG groups). Four weeks later mean arterial pressure (mAP) responses to NO donor - heterocyclic furoxan C-21, non-selective inhibitor of NO-synthase - L-NAME and alfa-1 adrenergic agonist - phenylephrine (PE) were examined. To diagnostic MCT-induced PH right ventricular systolic pressure (RVP) and ratio of right ventricular of heart hypertrophy (Mrv/Mh) was also examined. In MCT-C group RVP was increased [76±10 vs. 26±2 mm Hg in C-C group, p<0.05] and Mrv/Mh was also increased [33.1±2 vs. 23.2±1.5 mm Hg in C-C group, p<0.01]. In MCT-AG group RVP was decreased to 47±5 mm Hg vs. MCT-C group (p<0.05), whereas Mrv/Mh didn’t change. In MCT-C group the mAP responses to C-21 and L-NAME were decreased [-14.4±2 vs. -23.5±3 mm Hg in C-C group, P<0.05 and 20.7±4 vs. 33.8±2 mm Hg in C-C group, P<0.05, respectively], mAP responses to PE were also decreased [12.4±2 vs. 21.9±4 mm Hg in C-C group, P<0.05]. This impairment of mAP responses was prevented by AG treatment in cases of C-21 [-29.8±3 mm Hg vs. MCT-C group, P<0.05] and L-NAME [34.6±3 mm Hg vs. MCT-C group, P<0.05], whereas hypertensive responses to PE didn’t change. These results suggest that chronic administration of AG didn’t prevent development of PH but improved function of cardiovascular system and restored mAP responses both to exogenous NO (experiments with C-21) and endogenous NO (experiments with L-NAME).
Correspondence: Still no evidence for single photon detection by humans (2017)

The rod photoreceptors in the retina are known to be sensitive to single photons, but it has long been debated whether these single-photon signals propagate through the rest of the visual system and lead to perception. Recently, single-photon sources developed in the field of quantum optics have enabled direct tests of single-photon vision that were not possible with classical light sources. Using a heralded source based on spontaneous parametric downconversion to generate single photons which were sent to an observer at either an early or late time, Tinsley and Molodtsov et al. (2016) had observers judge when the photon was seen. Based on the above-chance accuracy in both a subset of high-confidence trials and in all post-selected trials, they claimed to show that humans can see single photons. However, we argue that this work suffers from three major issues: self-contradicting results, inappropriate statistical analyses, and a critical lack of statistical power. As a result, we cannot conclude that humans can see single photons based on the data of this study. We present a careful examination of the statistical analyses and the internal consistency of the data, which indicated that none of the key evidence holds.
A Low-PAPR High-Rate Full-Diversity 4x4 Space-Time Code with Fast Maximum-Likelihood Decoding (2010)

From a practical point of view, fast Maximum Likelihood Decoding (MLD) and low Peak-to-Average-Power- Ratio (PAPR) are two important design criteria for Space-Time Block Codes (STBCs). The use of the principle of conditional detection allows for having high-rate STBCs while keeping the complexity of detection at a reasonable level. Recently, we proposed a structure for a STBC with fast MLD having a rate of 3/2 complex symbols per channel use. In this paper, the PAPR criterion is included in the code design, and a modified version is proposed which has a lower PAPR.
Accumulation of Tumor-Infiltrating CD49a+ NK Cells Correlates with Poor Prognosis for Human Hepatocellular Carcinoma (2019)

The discovery of CD49a<sup>+</sup> liver-resident natural killer (NK) cells in mice alters our view of NK cells and provides another opportunity to study NK cells. Although evidence has suggested roles for NK cells in liver diseases, whether and how CD49a<sup>+</sup> NK cells contribute to liver diseases remain unclear. In this study, we observed that accumulation of CD49a<sup>+</sup> tissue-resident NK cells in human hepatocellular carcinoma (HCC) was higher than in peritumoral tissues. We studied the exhausted and regulatory phenotypes of CD49a<sup>+</sup> tissue-resident NK cells by analysis of protein and mRNA. The proportion of CD49a<sup>+</sup> NK cells was positively correlated to the proportion of NK cells expressing inhibitory receptors. In addition, CD49a<sup>+</sup> NK cells expressed more of checkpoint molecules PD-1, CD96, and TIGIT. Transcriptomic analysis implicated CD49a<sup>+</sup> tissue-resident NK cells in the negative regulation of immune responses. Comparison of murine and human CD49a<sup>+</sup> NK cells revealed their distinct characteristics and functions. Finally, accumulation of tissue-resident CD49a<sup>+</sup> NK cells in liver tumor was correlated to deteriorating disease condition and poor prognosis. Our findings show that CD49a<sup>+</sup> NK cells accumulate in liver tumor and suggest a role for CD49a<sup>+</sup> NK cells in the negative regulation of immune responses and the development of HCC.
T9. CROSS-SECTIONAL ASSOCIATION OF MEMBRANE FATTY ACID COMPOSITION AND PSYCHOPATHOLOGY IN THE NEURAPRO-E STUDY (2018)

favor of a state-trait dichotomy being present in NSS and thus challenges the view that NSS depict an endophenotype.
El coaching ejecutivo en América Latina (2011)

Mientras que el coaching ejecutivo se ha ganado un lugar en la agenda de muchos ejecutivos de linea y profesionales de RR.HH., poco se sabe en cuanto a su difusion, uso y resultados. Con el estudio por los autores, se busca dar un primer paso para llenar este vacio, con la esperanza de contribuir a la mejora de su practica en las empresas de la region. Hallaron que en poco tiempo, el coaching ejecutivo llego a una difusion de 84,6% en las empresas de su muestra. El uso del coaching ejecutivo se concentra principalmente en la alta direccion y los empleados de alto potencial, y tiene por objetivo contribuir a la mejora de la performance del coacheado o al desarrollo de capacidades especificas. A partir de la diferenciacion entre empresas que obtienen buenos resultados de las intervenciones de coaching que organizan y las que no, los autores llegan a dos importantes conclusiones.

Primero, no existen diferencias significativas en la organizacion y la estructura de los procesos de coaching. Desde los criterios usados para seleccionar el coach, pasando por la duracion de sesiones y procesos, hasta las redes de soporte al coacheado, en ninguna dimension hay diferencias que expliquen variaciones importantes en el desempeno.

Segundo, las variables del contexto organizacional tienen un fuerte impacto. Por lo tanto, es necesario preparar la organizacion antes de iniciar intervenciones de coaching mediante tres pasos: aclarar su proposito a partir de argumentos de negocio, desarrollar habilidades de coaching y difundirlo desde la alta direccion hacia el resto de la organizacion.
Anti-Inflammatory, Antipyretic, and Analgesic Effects of <i>Lawsonia inermis L.</i>(Henna) in Rats (1995)

Crude ethanolic extract of Lawsonia inermis L. (0.25-2.0 g/kg) produced significant and dose-dependent anti-inflammatory, analgesic, and antipyretic effects in rats. The extract also produced significant increases in pentobarbitone-induced sleeping time. Using a liquid-liquid extraction procedure, the extract was fractionated into chloroform, butanol, and water fractions, and these were tested for the above activities. The butanol and chloroform fractions showed more potent anti-inflammatory, analgesic, and antipyretic effects than the crude extracts, while the aqueous extract showed significantly less effect. As compared with the other extracts, the butanolic extract (500 mg/kg) was the most effective in the analgesic test. From the chloroform extract, a pure compound was isolated and identified, using chromatographic and spectroscopic techniques, as 2-hydroxy-1,4-naphthaquinone (lawsone). The isolated compound was found to possess significant anti-inflammatory, analgesic, and antipyretic activity. It potentiated significantly the pentobarbitone-induced sleeping time. The anti-inflammatory effect of lawsone (500 mg/kg) was not significantly different from that of the reference drug phenylbutazone (100 mg/kg).
Continuously tunable compact lasers based on thermo-optic polymer waveguides with Bragg gratings (2008)

Based on the thermo-optic tuning of a polymer waveguide Bragg reflector, we demonstrated a cost-effective tunable wavelength laser for WDM optical communications. The excellent thermo-optic effect of the polymer waveguide enabled direct tuning of the Bragg reflection wavelength by controlling the electrical power on a micro-heater. Wavelength tuning for 32 channels with 0.8 nm wavelength spacing was demonstrated as well as a continuous tuning with wavelength steps of 0.1 nm. To be qualified as a tunable laser for WDM-PON applications, wavelength stability within 0.15 nm was confirmed for an operating temperature range from -10 to 70 degrees C.
100 MW electron gun for a 34.3 GHz magnicon (2002)

A 100 MW advanced Pierce gun is described that was built for a 34.3 GHz magnicon amplifier. The gun has a computed beam diameter of /spl sim/0.9 mm when matched into a 13 kG magnetic field. The diameter of the cathode is 50 min. Hence, the beam area compression ratio is /spl sim/3000:1.
Targeted integration of foreign genes into repetitive sequences of the Brevibacterium lactofermentum chromosome (1996)

Directed integration of heterologous DNA into the insertion sequence IS13869 of Brevibacterium lactofermentum has been achieved by using integrative vectors that contain a 600 bp fragment from IS13869 and a kanamycin resistance cartridge with unique PacI, SwaI and PmeI sites. The incorporation of these restriction sites for rare-cutting enzymes, which recognize octanucleotide sequences, allowed rapid mapping of the location of plasmid insertion into the chromosome. Mapping by pulsed-field gel electrophoresis and hybridization with an IS13869 probe showed four types of transformants. In three of these types, integration of the vector occurred at each of three different sites in the chromosome. These vectors have the advantage of increasing the number of integration events due to the presence of multiple targets in the genome.
CLID: Controlled-Length Image Descriptions with Limited Data (2022)

Controllable image captioning models generate human-like image descriptions, enabling some kind of control over the generated captions. This paper focuses on controlling the caption length, i.e. a short and concise description or a long and detailed one. Since existing image captioning datasets contain mostly short captions, generating long captions is challenging. To address the shortage of long training examples, we propose to enrich the dataset with varying-length self-generated captions. These, however, might be of varying quality and are thus unsuitable for conventional training. We introduce a novel training strategy that selects the data points to be used at different times during the training. Our method dramatically improves the length-control abilities, while exhibiting SoTA performance in terms of caption quality. Our approach is general and is shown to be applicable also to paragraph generation.
Specific Internalisation of Gold Nanoparticles into Engineered Porous Protein Cages via Affinity Binding (2016)

Porous protein cages are supramolecular protein self-assemblies presenting pores that allow the access of surrounding molecules and ions into their core in order to store and transport them in biological environments. Protein cages' pores are attractive channels for the internalisation of inorganic nanoparticles and an alternative for the preparation of hybrid bioinspired nanoparticles. However, strategies based on nanoparticle transport through the pores are largely unexplored, due to the difficulty of tailoring nanoparticles that have diameters commensurate with the pores size and simultaneously displaying specific affinity to the cages' core and low non-specific binding to the cages' outer surface. We evaluated the specific internalisation of single small gold nanoparticles, 3.9 nm in diameter, into porous protein cages via affinity binding. The E2 protein cage derived from the Geobacillus stearothermophilus presents 12 pores, 6 nm in diameter, and an empty core of 13 nm in diameter. We engineered the E2 protein by site-directed mutagenesis with oligohistidine sequences exposing them into the cage's core. Dynamic light scattering and electron microscopy analysis show that the structures of E2 protein cages mutated with bis- or penta-histidine sequences are well conserved. The surface of the gold nanoparticles was passivated with a self-assembled monolayer made of a mixture of short peptidols and thiolated alkane ethylene glycol ligands. Such monolayers are found to provide thin coatings preventing non-specific binding to proteins. Further functionalisation of the peptide coated gold nanoparticles with Ni2+ nitrilotriacetic moieties enabled the specific binding to oligohistidine tagged cages. The internalisation via affinity binding was evaluated by electron microscopy analysis. From the various mutations tested, only the penta-histidine mutated E2 protein cage showed repeatable and stable internalisation. The present work overcomes the limitations of currently available approaches and provides a new route to design tailored and well-controlled hybrid nanoparticles.
The Effect of Swaging Work and Magnetic Annealing on Magnetic Properties of Mn-Bi Alloys (1976)

A new processing for MnBi permanent magnets was studied. Mn-Bi specimens were obtained by the following processes:(1) cast into metal mould→magnetic annealing (1 hr at 300°C, 5 kOe)→swaging→magnetic annealing (1 hr at 300°C, 5 kOe), and(2) cast into metal mould→swaging→magnetic annealing (1 hr at 300°C, 5 kOe).It was found that the specimens obtained by the process (2) showed desirable magnetic properties for parmanent magnets. In this process, swaging reduced the MnBi compounds to fine particles and caused an increase in coercive force. The following heat treatment in a magnetic field improved the value of 4πI10K and 4πIr without any decrease in coercive force. The value of maximum magnetic energy product was 6.1 MGOe in a 40 at%Mn-Bi alloy swaged to 92% reduction.
Role of a Noninnocent Pincer Ligand in the Activation of CO2 at (PNN)Ru(H)(CO) (2012)

This communication describes the activation of CO2 at the Ru pincer complex (PNN)Ru(H)(CO) (PNN = 6-(di-tert-butylphosphinomethylene)-2-(N,N-diethylaminomethyl)-1,6-dihydropyridine). The reaction proceeds to completion within minutes at room temperature to form a C–C bond between the pincer ligand and the electrophilic carbon atom of CO2. The characterization of both the kinetic and thermodynamic products of CO2 activation and the reversibility of this C–C bond formation are discussed.
Functional significance of increased airway smooth muscle in asthma and COPD (1993)

Using a computational model, we investigated the effect of the morphologically determined increased airway smooth muscle mass, adventitial mass, and submucosal mass observed in patients with asthma and chronic obstructive pulmonary disease (COPD) on the increase in airway resistance in response to a bronchoconstricting stimulus. The computational model of Wiggs et al. (J. Appl. Physiol. 69: 849-860, 1990) was modified in such a way that smooth muscle shortening was limited by the maximal stress that the muscle could develop at the constricted length. Increased adventitial thickness was found to increase constriction by reducing parenchymal interdependence. Increased submucosal thickness led to greater luminal occlusion for any degree of smooth muscle shortening. Increased muscle thickness allowed greater smooth muscle shortening against the elastic loads provided by parenchymal interdependence and airway wall stiffness. We found that for constant airway mechanics, as reflected by the passive area-pressure curves of the airways, the increased muscle mass is likely to be the most important abnormality responsible for the increased resistance observed in response to bronchoconstricting stimuli in asthma and COPD. For a given maximal muscle stress, greater muscle thickness allows the development of greater tension and thus more constriction of the lumen.
Summary Abstract: Experimental study of interfacial Na+ ‘‘impurities’’ in Si metal–oxide-semiconductor structures (1985)

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