gebhart/patrepeval huggingface dataset:
Control of the Corpora Allata During a Reproductive Cycle in a Viviparous Cockroach (1981)

SYNOPSIS. This paper describes factors which regulate the corpora allata (CA) during the reproductive cycle in the viviparous cockroach Diploptera punctata. Experiments, designed to alter the rate of juvenile hormone (JH) synthesis by the CA, are performed on whole animals and their effects are demonstrated by an in vitro radiochemical assay for JH synthesis by the CA. The CA is both inhibited and stimulated. Axonal pathways from the brain to the CA are required for inhibition of the CA in virgin females but not in young pregnant females. Humorally transmitted inhibition of the CA is caused in vivo by JH (in high titers) and ecdysteroid hormone. JH in low titers also stimulates the CA. Since these hormones do not affect the CA in vitro we suggest that they exert their effect via the central nervous system. The ovary, a possible source of ecdysteroids in the hemolymph, is necessary both for maintenance of JH synthesis and for inhibition in the rate of JH synthesis at the end of egg growth.
The Ion Conductances of CFPAC-1 Cells (1993)

The CFPAC-1 cell line was derived from a pancreas duct carcinoma from a patient suffering from ΔF 508 cystic fibrosis (CF). This cell therefore should be well suited to study the Cl– transport defect in CF. We used slow whole cell (SWC) and cell-attached nystatin (CAN) patch clamp techniques to characterize these cells and we confirm that cAMP fails to induce Cl– currents. Ca2+-mobilizing agents such as neurotensin (NT), ATP, and carbachol all induce a depolarization together with an increase in conductance. This was revealed in SWC and in apical membrane CAN experiments. The half-maximal conductance effect of NT was at 10–9 mol/l, that of ATP at 10–6 mol/l. For carbachol, only 10–4 mol/l was examined. In CAN experiments, no clear current events were detectable in apical membrane patches, suggesting that the Cl– channel responsible for the measured increase in conductance has a conductance too small to be resolved as a single channel event. Hypotonic cell swelling also induced a biphasic voltage reponse with a predominant increase in Cl– conductance. This effect was detectable in SWC and CAN recordings for 240 mosm/1 NaCl and was further enhanced at 160 mosm/1 NaCl. The conductance sequence for this and the ATP-induced pathway was F = Br– = Cl–. Both pathways were inhibited equally well by 10–3 mol/l DIDS, and they were not additive with respect to their conductance effects. These data indicate that cell swelling as well as Ca2+ mobilization activates a Cl– conductance which consists of the synchronous activity of nondetectable single Cl– currents. These currents appear to be the same as those recently described in HT29 cells.
Representation-Aggregation Networks for Segmentation of Multi-Gigapixel Histology Images (2017)

Convolutional Neural Network (CNN) models have become the state-of-the-art for most computer vision tasks with natural images. However, these are not best suited for multi-gigapixel resolution Whole Slide Images (WSIs) of histology slides due to large size of these images. Current approaches construct smaller patches from WSIs which results in the loss of contextual information. We propose to capture the spatial context using novel Representation-Aggregation Network (RAN) for segmentation purposes, wherein the first network learns patch-level representation and the second network aggregates context from a grid of neighbouring patches. We can use any CNN for representation learning, and can utilize CNN or 2D-Long Short Term Memory (2D-LSTM) for context-aggregation. Our method significantly outperformed conventional patch-based CNN approaches on segmentation of tumour in WSIs of breast cancer tissue sections.
A Distributed Intelligence Automatic Test System for PATRIOT (1977)

An automatic test system supporting high volume production testing of diverse state-of-the-art electronic assemblies is described. The test complex consists of a centralized computer system communicating to a network of satellite stations, each structured as "Intelligent Test Centers" dedicated to a particular family of assemblies (e.g., analog, digital, microwave). Allocation of resources and tasks have been distributed for optimum efficiency of production testing. This paper describes the organization and characteristics of the test system. Test center operation is explained with emphasis given to unique man-machine interactive features designed for on-line generation, examination, and maintenance of Unit-Under-Test (UUT) programs. Details are presented of the test language, RATEL, used for UUT programming. Other aspects that are discussed include test data and UUT program characteristics.
Potential Distribution in Axisymmetric Mercury-Pool Electrolysis Cells at the Limiting Current (1973)

An expression has been obtained and graphs are presented for the potential distribution at a disk working electrode located at the bottom of a cylindrical cell, with the counterelectrode separator taken to be a uniform‐current disk placed concentrically at the solution level. The condition of maximum working electrode potential variations, i.e., when the working electrode current density is uniform, is examined in detail. For cells of typical size, the most sensitive geometrical parameter in determining the potential distribution is the height of the counterelectrode separator above the pool. Recommendations on the placement of the reference electrode probe are given.
Oxidative Amide Synthesis and N-Terminal α-Amino Group Ligation of Peptides in Aqueous Medium (2006)

A new method for oxidative synthesis of amides from alkynes and amines in high yields (up to 96%) using [Mn(2,6-Cl2TPP)Cl] 1 as a catalyst and Oxone/H2O2 as an oxidant in aqueous medium has been developed. This method could be used for N-terminal alpha-amino group ligation of unprotected peptides with aryl, aliphatic, and internal alkynes under mild conditions.
Correction.Synthesis and Optical Resolution of Calix[4]arenes with Molecular Asymmetry. Systematic Classificaton of All Possible Chiral Isomers Derivable from Calix[4]arene (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCorrection.Synthesis and Optical Resolution of Calix[4]arenes with Molecular Asymmetry. Systematic Classificaton of All Possible Chiral Isomers Derivable from Calix[4]areneKoji Iwamoto, Hiroyasu Shimizu, Koji Araki, and Seiji ShinkaiCite this: J. Am. Chem. Soc. 1993, 115, 25, 12228Publication Date (Print):December 1, 1993Publication History Published online9 February 2004Published inissue 1 December 1993https://pubs.acs.org/doi/10.1021/ja00078a600https://doi.org/10.1021/ja00078a600research-articleACS PublicationsRequest reuse permissionsArticle Views90Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Epstein-Barr virus DNA in serum as an early prognostic marker in children and adolescents with Hodgkin lymphoma (2017)

Assay of cell-free DNA in blood offers an approach to assessment of tumor DNA. We sought to determine whether Epstein-Barr virus (EBV) DNA in cell-free blood is also a good surrogate for the presence of tumor DNA in children with Hodgkin lymphoma, as it is in adults, and whether it correlates with pediatric outcomes. Pediatric patients enrolled in a Children's Oncology Group trial (AHOD0031) were studied at baseline and at 8 days after the initiation of treatment. At baseline, EBV DNA in cell-free blood correlated with the presence of EBV in tumor, and EBV DNA 8 days after the initiation of therapy predicted inferior event-free survival. EBV DNA in cell-free blood warrants further investigation as a marker of inadequate tumor response in Hodgkin lymphoma. This trial was registered at www.clinicaltrials.gov as #NCT00025259.
ChemInform Abstract: SYNTHESIS VIA SRN1 REACTIONS: PART IV. ONE‐POT SYNTHESIS OF 1‐OXO‐1,2‐DIHYDROISOQUINOLINES (ISOCARBOSTYRILS) VIA SRN1 (AR) REACTIONS (1982)

Abstract 2‐Halogenbenzamide (I) reagieren mit Ketonenolaten (II) in fl · Ammoniak unter Belichten über die Zwischenstufe (III) zu Isochinolin‐Derivaten (IV).
A Low Complexity VBLAST OFDM Detection Algorithm for Wireless LAN Systems (2004)

A low complexity detection algorithm for VBLAST OFDM system is presented. Using the fact that the correlation among neighboring subcarriers is high for wireless LAN channels, this algorithm significantly reduces the complexity of VBLAST OFDM detection. The performance degradation of the proposed algorithm is small compared to conventional detection.
Characterization of Membrane Proteins in Isolated Native Cellular Membranes by Dynamic Nuclear Polarization Solid‐State NMR Spectroscopy without Purification and Reconstitution (2011)

Membranproteine in ihrer natürlichen Zellmembran können ohne vorherige Reinigung durch Kombination dynamischer Kernpolarisation mit Festkörper-NMR-Spektroskopie unter Probenrotation um den magischen Winkel untersucht werden (siehe Bild). Die Empfindlichkeit, die zum Beobachten der Membranproteine notwendige ist, wird durch dynamische Kernpolarisation erreicht. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Gain-modulated Axi-Vision Camera (high speed high-accuracy depth-mapping camera) (2004)

We describe a novel real-time depth-mapping camera, the Gainmodulated Axi-Vision Camera, where pulsed laser light is combined with a gain-modulated camera. Depth resolution of 2.4 mm was obtained, which is higher than the resolution of the previously reported depth-mapping Axi- Vision Camera. Pixel-by-pixel depth information of 768 x 493 pixels is obtainable at one half of the video frame rate (15 Hz). A short movie clip is attached that illustrates the depth measurement operation. The merits of the Gain-modulated Axi-Vision Camera are high-resolution, real-time operation, and a relatively simple optical system. These merits primarily arise from the ultra-fast exposure time using a pulsed laser diode.
1-keV emission from laser-plasma source based on an Xe/He double stream gas puff target (2021)

Characterization of Xe emission in the spectral range between 1 and 1.5 keV is presented in the case when the laser-plasma is generated by nanosecond laser pulse irradiation of a double stream Xe/He gas-puff target. Gas target density was estimated using extreme ultraviolet (EUV) radiography. Emission spectral characteristics in the wavelength range from 0.8 to 5.2 nm were determined by using a flat field SXR spectrometer. Significant emission was recorded in two high-energy bands, the first one at wavelengths 0.8-1.6 nm (photon energy range 0.78-1.5 keV) and the second one at 1.6-2.5 nm (0.5-0.78 keV). Both plasma size and photon yield in each band were measured separately to individually assess radiation and source characteristics. Moreover, a proof-of-principle experiment for near-edge X-ray absorption fine structure spectroscopy of metallic sample near the L<sub>2,3</sub> absorption edge was performed to show one of the applicability areas of such a compact source.
Linewidth-narrowing of a continuous wave terahertz polariton laser using an intracavity etalon (2019)

An uncoated etalon was incorporated within an intracavity continuous wave terahertz polariton laser, leading to a tenfold reduction in linewidth, plus a factor of 2 increase in the THz output power. The increase in output power is explained in terms of phase matching considerations for the parametric downconversion process.
OUP accepted manuscript (2018)

Screening of monoclonal antibodies against ebolaviruses requires small-animal models. Wild-type mice require adaptation of ebolaviruses, whereas immunodeficient mice are still resistant to nonadapted Bundibugyo ebolavirus. Swapping of Ebola virus glycoprotein with that from Bundibugyo virus resulted in a replication-competent chimeric virus, which caused 100% lethal infection in STAT1 knockout mice. Monoclonal antibody BDBV223 isolated from a human survivor of Bundibugyo virus infection protected mice from challenge with the chimeric virus. These data demonstrate the suitability of the approach for in vivo screening of antibodies and suggest the greater contribution of internal Ebola proteins in pathogenesis compared to Bundibugyo virus proteins.
Lower Bound on Estimation Variance of the Ultrasonic Attenuation Coefficient Using the Spectral-Difference Reference-phantom Method (2016)

Ultrasonic attenuation is one of the primary parameters of interest in Quantitative Ultrasound (QUS). Non-invasive monitoring of tissue attenuation can provide valuable diagnostic and prognostic information to the physician. The Reference Phantom Method (RPM) was introduced as a way of mitigating some of the system-related effects and biases to facilitate clinical QUS applications. In this paper, under the assumption of diffuse scattering, a probabilistic model of the backscattered signal spectrum is used to derive a theoretical lower bound on the estimation variance of the attenuation coefficient using the Spectral-Difference RPM. The theoretical lower bound is compared to simulated and experimental attenuation estimation statistics in tissue-mimicking (TM) phantoms. Estimation standard deviation (STD) of the sample attenuation in a region of interest (ROI) of the TM phantom is measured for various combinations of processing parameters, including Radio-Frequency (RF) data block length (i.e., window length) from 3 to 17 mm, RF data block width from 10 to 100 A-lines, and number of RF data blocks per attenuation estimation ROI from 3 to 10. In addition to the Spectral-Difference RPM, local attenuation estimation for simulated and experimental data sets was also performed using a modified implementation of the Spectral Fit Method (SFM). Estimation statistics of the SFM are compared to theoretical variance predictions from the literature.<sup>1</sup> Measured STD curves are observed to lie above the theoretical lower bound curves, thus experimentally verifying the validity of the derived bounds. This theoretical framework benefits tissue characterization efforts by isolating processing parameter ranges that could provide required precision levels in estimation of the ultrasonic attenuation coefficient using Spectral Difference methods.
Role of Conserved Histidine Residues inD-Aminoacylase fromAlcaligenes xylosoxydanssubsp.xylosoxydansA-6 (2000)

D-Aminoacylase from Alcaligenes xylosoxydans subsp. xylosoxydans A-6 (Alcaligenes A-6) was strongly inactivated by diethylpyrocarbonate (DEPC). An H67N mutant was barely active, with a kcat/Km 6.3 x 10(4) times lower than that of the recombinant wild-type enzyme, while the H67I mutant lost detectable activity. The H67N mutant had almost constant Km, but greatly decreased kcat. These results suggested that His67 is essential to the catalytic event. Both H69N and H69I mutants were overproduced in the insoluble fraction. The kcat/Km of H250N mutant was reduced by a factor of 2.5 x 10(4)-fold as compared with the wild-type enzyme. No significant difference between H251N mutant and wild-type enzymes in the Km and kcat was found. The Zn content of H250N mutant was nearly half of that of wild-type enzyme. These results suggest that the His250 residue might be essential to catalysis via Zn binding.
Wind tunnel test of a model rotor with a free-tip (1986)

A model helicopter rotor with a free tip was tested in a wind tunnel to show the effect of the free tip on rotor performance and oscillatory loads. The free-tip rotor has blade tips that are free to pitch independently of the remainder of the blade. A nearly constant pitching moment is applied to the tip so the tip will produce a nearly steady lift around the azimuth. The aerodynamic development of the free tip is reviewed. The development process concentrated on configuring the tip to have the capability of fast response to angle-of-attack perturbations. Wind tunnel test results show the free-tip rotor configuration requires less power than a fixed-tip configuration in forward flight. In addition, the free tip causes substantial reduction in blade-flapwise vibratory loads. However, blade-chordwise loads were increased. Pitch-link vibratory loads were also reduced by the free-tip configuration. Discussion is presented on the reasons that the use of the free tip caused reduced power and smaller vibratory loads.
Supplementary Table S6 from Multiparametric MRI and Coregistered Histology Identify Tumor Habitats in Breast Cancer Mouse Models (2023)

&lt;p&gt;Similarity index based on the weighted moving/sliding window was used to quantify the agreement for all wrong classifications between the habitats-map derived from MRI (5-parameters) and histology. The correct habitats from histological maps were compared with incorrect habitats from MRI maps. Thus, there were 9 incorrect classifications for maps containing V, H1, H2 and N, and 2 incorrect classifications for maps containing V, combined H1 + H2 and N to compare. The total average score for all wrong classifications for each sample is also shown in Supplementary Table 5.&lt;/p&gt;
Exploring Halogen Bonds in 5-Hydroxytryptamine 2B Receptor-Ligand Interactions (2020)

Here, we predicted the potential halogen bonding interaction between compound 2 and the 5-hydroxytryptamine 2B (5-HT2B) receptor and systematically assessed this interaction via structure-activity relationship analysis and molecular dynamics simulations. A physics-based computational protocol was then developed to further explore the opportunity of "designing in" halogen bonding interactions in structure-based ligand design for the 5-HT2B receptor, which not only facilitated the identification of previously uncharacterized halogen bonds in known 5-HT2B ligands but also enabled the rational design of halogen bonding interactions for the optimization of 5-HT2B ligands. As a proof-of-concept, a series of halogen-substituted analogues of doxepin was synthesized and evaluated, which showed improved in vitro and in vivo potency.
Sidelink-Assisted URLLC Built on Cooperative Retransmissions With Optimum Power Control (2021)

The fifth generation of wireless technology (5G) has advanced exceptionally in the past few years, giving rise to challenging quality of service (QoS) requirements and diverse deployment scenarios. Among the set of available services, ultra-reliable low-latency communication (URLLC) imposes stringent reliability and latency requirements. For improving the reliability under strict latency constraints in an error-prone downlink (DL), we have proposed a sidelink (SL)-assisted cooperative retransmission scheme, which takes advantage of multiple independently fading device-to-device (D2D) links. For the cooperative scheme, power control is useful for balanced user contributions and to control additional interference imposed to the system. Hence, this paper focuses on designing an optimal power control for the cooperative sidelink retransmission scheme, which gradually increments the power with every retransmission attempt. The objective is to utilize minimum power without compromising the desired latency and reliability performance. Results from system level evaluation reveal significant power savings in comparison to the reference power control scheme, which uses the maximum transmit power per device, limited by the DL path-loss power constraint only.
Two-cavities approach for resection of pediatric abdominal neuroblastic tumors: experience of a national reference pediatric onco-surgical center (2022)

The two-cavities approach for resection of abdominal neuroblastoma in children is a safe technique with no added morbidity.
Modelling of the Annual Mean Urban Heat Island Pattern for Planning of Representative Urban Climate Station Network (2011)

The spatial distribution of the annual mean urban heat island (UHI) intensity pattern was analysed for the medium-sized city Novi Sad, Serbia, located on the low and flat Great Hungarian Plain. The UHI pattern was determined by an empirical modelling method developed by (Balázs et al. 2009). This method was based on datasets from urban areas of Szeged and Debrecen (Hungary). The urban study area in Novi Sad (60 km 2 ) was established as a grid network of 240 cells (0.5 km ×0.5 km). A Landsat satellite image (from June 2006) was used in order to evaluate normalized difference vegetation index and built-up ratio by cells. The pattern of the obtained UHI intensity values show concentric-like shapes when drawn as isotherms, mostly increase from the suburbs towards the inner urban areas. Results of this thermal pattern and determination of one of the local climate classification systems were used for recommending 10 locations for representative stations of an urban climate network in Novi Sad.
Dual-well 3D vertical seismic profile enabled by distributed acoustic sensing in deepwater Gulf of Mexico (2015)

Abstract We have acquired and processed 3D vertical seismic profile (VSP) data recorded simultaneously in two wells using distributed acoustic sensing (DAS) during the acquisition of the 2012 Mars 4D ocean-bottom seismic survey in the deepwater Gulf of Mexico. The objectives of the project were to assess the quality of DAS data recorded in fiber-optic cables from the surface to the total depth, to demonstrate the efficacy of the DAS VSP technology in a deepwater environment, to derisk the use of the technology for future water injection or production monitoring without intervention, and to exploit the velocity information that 3D VSP data provide for evaluating and updating the velocity model. We evaluated the advantages of DAS VSP to reduce costs and intrusiveness, and we determined that high-quality images can be obtained from relatively noisy raw 3D DAS VSP data, as evidenced by the well 1 image, probably the best 3D VSP image we have ever seen. Our results also revealed that the direct arrival traveltimes can be used to assess the quality of an existing velocity model and to invert for an improved velocity model. We identified issues with the DAS acquisition and the processing steps to mitigate them and to handle problems specific to DAS VSP data. We described the steps for conditioning the data before migration, reverse time migration, and postmigration processing to reduce noise artifacts. We outlined a novel first-break picking procedure that works even in the absence of a strong first arrival and a velocity diagnosis method to assess and validate velocity models and velocity updates. Finally, we determined potential applications to 4D monitoring of fluid movement around producer or injector wells, identification of active salt movements, and more accurate imaging and monitoring of complex structures around the wells.
Eating dark and milk chocolate: a randomized crossover study of effects on appetite and energy intake (2011)

In the present study, dark chocolate promotes satiety, lowers the desire to eat something sweet, and suppresses energy intake compared with milk chocolate.