gebhart/patrepeval huggingface dataset:
Effect of Nutrients and Antioxidant Enzyme Activities from Microcystis aeruginosa (2016)

The fresh water microalgae Microcystis aeruginosa has been examined for its chlorophyll-a and antioxidant enzymatic activities in different nitrate and phosphate concentrations. In the experiment, M. aeruginosa were cultured 28 days at 18°C, 25°C and 30°C in various light intensity. The maximum chlorophyll-a content was 33.79 (mg/L) in phosphate (460 µM) at 30℃. Superoxide dismutase (SOD) was significantly higher of 66.53% in phosphate (980 µM) at 30℃. DPPH radical scavenging activity of 78.16 % in the nitrate (329.5µM) at 18℃. The results showed that the maximum chlorophyll-a recorded at 30℃ from N:P, P and N respectively. DPPH increased with nitrate concentration during the lower temperature and the SOD increased with phosphate in highest temperature. Chlorophyll- a content significantly compared with 18℃ and 30℃ (P < 0.05).
Hierarchical analysis of factors influencing acceptance of remanufactured medical devices (2021)

The growth of remanufacturing has seen its application in different industrial sectors including automotive, electronics and medical devices. In medical and healthcare sector, remanufacturing presents an opportunity to equip facilities with functional, safe, affordable and sustainable medical systems. However, there is a lack of understanding of the key factors that influence customers' acceptance of remanufactured medical devices. This study addresses this gap by analysing and ranking key factors that impact customers' decisions to purchase and use remanufactured medical systems using pairwise comparisons obtained from the analytical hierarchical process (AHP) model. The structural decision hierarchy was developed followed by a description of the adopted scale of importance. Thereafter, pairwise comparisons were performed by the expert panel constituted by six medical equipment experts with a total of 194 years’ experience between them. The responses were tested for rationality and consistency, the analysis of the comparisons was performed, and factor weights obtained for each factor. Results obtained ranked product quality as the most critical factor affecting acceptance of remanufactured devices followed by price, warranty, brand equity, available information, added value services and environmental friendliness. Findings from this study highlight the peculiarity of medical devices remanufacturing which gives more attention to product quality in terms of performance and safety. Taken together, these results provide a basis on which medical devices remanufacturers can improve customer acceptance. Before this study, discussions on customer acceptance of remanufactured medical devices were purely anecdotal and this is the first comprehensive investigation of customer factors in medical devices remanufacturing.
RanBPM Is a Phosphoprotein That Associates with the Plasma Membrane and Interacts with the Integrin LFA-1 (2004)

Integrin adhesion receptors can act as signaling receptors that transmit information from the extracellular environment to the interior of the cell, affecting many fundamental cellular processes, such as cell motility, proliferation, differentiation, and survival. Integrin signaling depends on the formation of organized sub-membrane complexes that comprise cytoskeletal, adapter, and signaling molecules. The identification of molecules that interact with the cytoplasmic domain of integrins has been the focus of research aimed to elucidating the mechanistic basis of integrin signal transduction. We have identified RanBPM as a novel interactor of the beta(2) integrin LFA-1 in a yeast-two-hybrid screen. In the same assay, RanBPM also interacted with the beta(1) integrin cytoplasmic domain. We demonstrate that RanBPM is a peripheral membrane protein and that integrins and RanBPM interact in vitro and in vivo and co-localize at the cell membrane. We find that RanBPM is phosphorylated on serine residues; phosphorylation of RanBPM is increased by stress stimuli and decreased by treatment with the p38 kinase inhibitor SB203580. Transfection of RanBPM synergizes with LFA-1-mediated adhesion in the transcriptional activation of an AP-1-dependent promoter, indicating that the two proteins interact functionally as well. We suggest that RanBPM may constitute a molecular scaffold that contributes to coupling LFA-1 and other integrins with intracellular signaling pathways.
Plasminogen activator inhibitors (PAI‐1 and PAI‐2) in normal pregnancies, pre‐eclampsia and hydatidiform mole (1993)

PAI-2 levels fell significantly in pre-eclampsia probably as a result of decreased placental mass or function. The raised PAI-1 level in pre-eclampsia may reflect a response to hypertension or renal damage that is not specific to pregnancy or may reflect altered placental function. The use of the ratio of PAI-1/PAI-2 assists in separating normal from abnormal pregnancies.
Verschillende methoden om mycotoxineproductie en de impact op de diergezondheid tegen te gaan (2013)

De aanwezigheid van mycotoxines in veevoeder kan aanzienlijke schade aan de diergezondheid toebrengen. Dit kan tot beduidende economische verliezen leiden voor de veehouderij. In dit overzichtsartikel worden de belangrijkste maatregelen weergegeven om mycotoxineproductie tegen te gaan en haar effect op de diergezondheid te verminderen. Zowel de mogelijke maatregelen vóór als na de oogst en een overzicht van de verschillende mycotoxine-detoxifi cerende producten worden besproken. De huidige wetgeving met betrekking tot maximum toegelaten gehaltes of indicatieve waarden van mycotoxines in verschillende voeders wordt eveneens vermeld. Deze wetgeving stelt de landbouwindustrie in staat om de resultaten van voederanalysen te interpreteren en te beslissen om al dan niet maatregelen te treffen.
Supplementary Materials and Methods from Mouse Models of Pediatric Supratentorial High-grade Glioma Reveal How Cell-of-Origin Influences Tumor Development and Phenotype (2023)

&lt;p&gt;Supplementary Materials and Methods&lt;/p&gt;
Quantification and characterization of microplastics in surface water samples from the Northeast Atlantic Ocean using laser direct infrared imaging (2023)

15 filtration samples were collected at eight locations onboard the RV Sonne (cruise SO279 in 2020) from 6 m water depth using a fractionated stainless-steel filtration unit. The size fraction > 300 μm was visually examined and potential microplastic particles were analyzed by ATR-FTIR spectroscopy. The treatment of size class 20 μm < d < 300 μm was based on enzymatic-oxidative microwave-assisted "one-pot" matrix digestion in conjunction with analysis of the microplastics by time-efficient LDIR imaging. Total number concentrations ranged from 47 to 2154 microplastic particles per m<sup>3</sup> (average for all stations: 500 ± 700 microplastic particles m<sup>-3</sup> (1 SD; n = 8)). In total, 20 polymer types were identified. The most common polymer types were polyethylene terephthalate (20 %) and acrylates/polyurethane/varnish (15 %). 93 % of the detected microplastics were smaller than 100 μm in length. Analysis of sample replicates indicates high spatio-temporal variations in microplastic pollution within the investigated region.
Federation of European Neuroscience Societies 2000 meeting (2000)

Many AAA members conducting neuroscience research have productive collaborative relationships with their European colleagues. It therefore seems appropriate to announce that the Federation of European Neuroscience Societies (FENS) will hold its annual meeting in Brighton, UK, June 24-28, 2000, at the Metropole Hotel and Brighton Conference Center. There will be a Special Interest Workshop on Three-Dimensional Microscopy on June 29. The organizers have put together an outstanding meeting that is only briefly summarized here. Details are available at http://www.fens2000.org. Prior to the FENS meeting, there will be two days of Satellite Symposia covering topics such as Synaptic Plasticity (contact Prof. Zafar Bashir, email z.i.bashir@bristol.ac.uk;), Knockouts and Mutants: Genetically Dissecting Brain and Behavior (contact Prof. W.E. Crusio, crusio@cnrs-orleans.fr), The Artificial Intelligence-Neuroscience Interface (contact Prof. M.O. Shea, email m.o-shea@sussex.ac.uk), and Space Motion Processing in the Auditory Systems (contact Prof. D. McAlpine, email d.mcalpine@ucl.ac.uk). A Satellite Symposium of particular interest has been organized by Prof. Richard Apps and Prof. D. Marple- Horvat of the University of Bristol and Prof. Chris Miall of Oxford and is entitled The Significance of Inferior Olivary and Cerebellar Cortical Activity for Motor Control. The participants and their respective topics are: Dr. Tom Ruigrok (Rotterdam) Anatomical and physiological organization of olivary circuits Dr. Martin Garwicz (Lund) Functional organization of olivocerebellar zones and microzones Dr. Kris Horn (Phoenix) Inferior olive neuronal activity during behavior Dr. Shigeru Kitazawa (Tsukuba) Information conveyed by olivocerebellar afferents Dr. Steve Lee (Bristol) Gating of olivocerebellar afferent pathways Dr. Markus Juptner (Essen) What do the cerebellum and basal ganglia contribute to motor control: lessons from PET experiments Dr. Dilwyn Marple-Horvat (Bristol) Signal processing in paravermal and hemispheral cortex during visually guided stepping and reaching Dr. Yasushi Kobayashi (Okazaki) Temporal firing patterns of complex spikes of Purkinje cells in the cerebellar ventral paraflocculus during ocular following responses in moneys Dr. Timothy Ebner (Minneapolis) Combining movement direction and speed signals in the discharge of Purkinje cells: encoding velocity Dr. Chris Miall (Oxford) The lateral cerebellum and visually guided movements: evidence of a forward model For further information on this symposium please contact Prof. D. Marple-Horvat, email d.e.marple-horvat@ bristol.ac.uk. The overall FENS meeting will consist of Special Interest Workshops, Technical Workshops, several Plenary Lectures, 43 Symposia, and Special Interest Symposia. In addition there will be several other special presentations and lectures. For further information on this meeting, including general information on potential travel routes to Bristol, visit the web site http://www.fens2000.org.
Membrane hydrophone measurement and numerical simulation of HIFU fields up to developed shock regimes (2013)

For the characterization of high-intensity focused ultrasound (HIFU) fields, hydrophone measurements should be performed in water in the whole range of the radiated power; however, cavitation occurs at high output, leading to the destruction of the hydrophone. To avoid this problem, a new hydrophone with additional protective layers covering the electrodes was developed and tested in the experiments. A single-element 1-MHz focusing ultrasound source was used for detailed measurements of the acoustic field in the axial and lateral planes. Measurements were performed with a new membrane hydrophone up to the focal peak compressional and rarefactional pressures of 55.6 and of 12.8 MPa, respectively, when the shock front had already formed in the waveform. Numerical modeling for the beams of periodic waves with an initially uniform amplitude distribution was performed, based on the Khokhlov-Zabolotskaya-Kuznetsov equation. Numerical solutions were compared with the experimental data and found to be in good agreement (within 10%). The influences of the limited bandwidth and the spatial averaging effect of the hydrophone on the accurate measurements of the acoustic field parameters were also investigated.
Assessment of the Anticorrosion and Antifouling Performances of a Novel Hybrid Epoxy-Siliconized Coating (2017)

Abstract Preventing material loss due to corrosion and fouling of steel surfaces is a daunting challenge for the oil and gas industries. The use of protective polymeric coatings containing active biocides is an interesting approach to address this problem. The development of active anticorrosion/antifouling coatings via this approach requires a careful design and optimization of the coating matrix, the antibacterial activity of the biocide, and ultimately achieving a synergy between the two components. In this study, a novel hybrid epoxy-siliconized coating was synthesized through a sol-gel technique, and embedded with different organic and inorganic biocides. The parent coating and the coating embedded with biocides were applied on mild steel sheets and their corrosion protection performance was evaluated under laboratory conditions using electrochemical impedance spectroscopy (EIS) and visual observations. The field testing of the anticorrosion and antifouling properties of all coatings was conducted by the in-situ exposure of the coated panels to seawater at a marine exposure site. Both lab and field testing results indicate that some biocides have a positive impact on the anticorrosion and antifouling behavior of the hybrid coating, while other biocides lack a synergy with the newly-developed hybrid coating.
INVITED: Reducing Time and Effort in IC Implementation: A Roadmap of Challenges and Solutions (2018)

To reduce time and effort in IC implementation, fundamental challenges must be solved. First, the need for (expensive) humans must be removed wherever possible. Humans are skilled at predicting downstream flow failures, evaluating key early decisions such as RTL floorplanning, and deciding tool/flow options to apply to a given design. Achieving human-quality prediction, evaluation and decision-making will require new machine learning-centric models of both tools and designs. Second, to reduce design schedule, focus must return to the long-held dream of single-pass design. Future design tools and flows that never require iteration (i.e., that never fail, but without undue conservatism) demand new paradigms and core algorithms for parallel, cloud-based design automation. Third, learning-based models of tools and flows must continually improve with additional design experiences. Therefore, the EDA and design ecosystem must develop new infrastructure for ML model development and sharing.
Photoaffinity labeling on magnetic microspheres (PALMm) methodology for topographic mapping: preparation of PALMm reagents and demonstration of biochemical relevance (2003)

Photoaffinity labeling (PAL) is a technique widely used for identifying the binding-site within proteins. Although the classic method is both versatile and powerful, it suffers significant disadvantages, such as the need to radiolabel the PAL ligand, and the need to conduct highly complicated separations of both the labeled protein and the labeled peptides derived from it. Here, we propose a novel and universal methodology--Photo-Affinity Labeling on Magnetic microspheres (PALMm) designed to simplify and shorten the PAL protocol. In this context, we describe the preparation of PALMm reagents and the evaluation of their biochemical relevance regarding two ATP-binding enzymes: hexokinase and apyrase.
Attribute-Based Encryption with Non-Monotonic Access Structures. (2007)

We construct an Attribute-Based Encryption (ABE) scheme that allows a user’s private key to be expressed in terms of any access formula over attributes. Previous ABE schemes were limited to expressing only monotonic access structures. We provide a proof of security for our scheme based on the Decisional Bilinear Diffie-Hellman (BDH) assumption. Furthermore, the performance of our new scheme compares favorably with existing, less-expressive schemes. Categories and Subject Descriptors: E.3 [Data Encryption]: Public key cryptosystems. General Terms: Security.
The Molecular Genetics of the T-Cell Antigen Receptor and T-Cell Antigen Recognition (1986)

The genes encoding the alpha and beta chain of the T-cell receptor and the gamma gene have been cloned, and their structure, organization, ontogeny of expression, pattern of rearrangement, and diversification are now generally understood. In most cases, the immunoglobulin paradigm applied very well to the corresponding phenomena in T cells, although as described above, some interesting and potentially important differences exist. Nevertheless, there are still many unanswered questions regarding the ontogeny and mechanism of MHC-restricted antigen recognition, and it is not clear how far the immunoglobulin model can take us in understanding these phenomena. Although the alpha/beta heterodimer looks like an antibody and the binding sites of the two molecules may be similar, the rules governing B- and T-cell activation are clearly different, and the ligand(s) bound by the receptor are still poorly characterized. In the future, T-cell receptor genes, as well as those encoding the T-cell accessory molecules, will be altered in vitro and transferred into mammalian cells in culture and into whole organisms in an attempt to understand T-cell antigen recognition. These tools will allow us to manipulate the mammalian immune response in a variety of different ways that will have a profound impact both on our understanding of immunology and on medicine in the future.
Interface Shear Performance of Full-Scale Composite UHPC Box Beams (2023)

A new ultra-high-performance concrete (UHPC) composite beam section was developed for use on short-span bridges in Pennsylvania. Due to the shallow nature of the section, interface shear strength plays a significant role in the design of the system. In order to enhance the horizontal shear capacity between the UHPC precast beam and cast-in-place (CIP) conventional concrete deck, either increase the stirrups at interface or an intentionally roughened top flange surface of the UHPC beam are considered. Due to the rheology of UHPC, conventional scoring techniques are not effective in creating adequate roughness. Therefore, keyed surface on the top flange which serves as the intentionally roughed surface is proposed in this study. Two designs for the connections between the concrete deck and the UHPC beam are presented and compared. It was found that the design with keyed surface reduce the usage of interface stirrup by 92%, therefore is preferred and selected for further investigation. Two composite UHPC box beams will be experimentally investigated in the future study. Different factors affecting the horizontal shear capacity of the composite UHPC beam will be discussed, namely, the geometry of keyed surface, and effective interface reinforcement details.
Target-Induced Horseradish Peroxidase Deactivation for Multicolor Colorimetric Assay of Hydrogen Sulfide in Rat Brain Microdialysis (2018)

Hydrogen sulfide (H<sub>2</sub>S) is important for normal neural functions, which involves protecting neurons from oxidative stress and neuronal transmission modulation in brain. The detection of H<sub>2</sub>S is significant for revealing its role in the diagnosis of various disease. In this study, a novel multicolor colorimetric assay based on the etching of gold nanorods (Au NRs) is proposed to evaluate H<sub>2</sub>S level with the naked eye. This measurement relies on the catalytic oxidation of 3,3',5,5'-tetramethylbenzidine (TMB) via horseradish peroxidase (HRP) to produce TMB<sup>2+</sup>, which could etch the Au NRs quickly and accompany with a distinct color change. The vivid colors can be easily distinguished with the naked eye without any sophisticated instruments. The presence of H<sub>2</sub>S can cause the deactivation of HRP, which affects the amount of TMB<sup>2+</sup> produced and consequently affects the color changing of the system. Based on this mechanism, a simple but sensitive multicolor colorimetric assay is developed for H<sub>2</sub>S detection with a linear range of 0.05-50 μM. The proposed method is demonstrated for monitoring extracellular H<sub>2</sub>S in rat brain coupled with microdialysate.
Matrix Effects on Spin−Lattice Relaxation in the Triplet State of Tryptophan (1997)

Spin−lattice relaxation (SLR) of the photoexcited triplet state of tryptophan both as the free amino acid (Trp) and also incorporated at a buried site of ribonuclease T1 from Aspergillus oryzae (RNase T1) is investigated in the ethylene glycol (EG)−water mixed solvent system. Global analysis of microwave-induced delayed phosphorescence (MIDP) transients measured at 1.2 K is employed to obtain the triplet state kinetic parameters over a range of solvent composition between 10 and 90 vol % EG. These parameters are used to calculate the phosphorescence decay profile of the triplet states that contribute to the MIDP. The experimental phosphorescence profile is fitted at each solvent composition as the sum of the calculated nonexponential decay and a simple exponential decay with lifetime equal to the average tryptophan lifetime. The phosphorescence is modeled to originate from two distinct populations characterized by either slow SLR or rapid SLR relative to the triplet state lifetime. Only the former contributes to the MIDP signals while the latter is responsible for the exponential decay component. The fraction of tryptophan undergoing slow SLR, Φs, is at a maximum (ca. 0.7) for EG in the range 30−40% (v/v) for both Trp and RNase T1, diminishes sharply with increasing water content, and diminishes slightly with increasing EG content. The SLR of this population is independent of solvent composition. Since the tryptophan triplet state is not kinetically homogeneous in EG−water, the method of microwave-saturated phosphorescence decay analysis produces erroneous kinetic parameters for this system. The native RNase T1 structure becomes unstable above 60 vol % EG as revealed by changes in phosphorescence and ODMR.
Impact of oral naloxegol vs subcutaneous methylnaltrexone in treatment of opioid-induced constipation in the hospital setting (2022)

Oral naloxegol may be an effective, cost-efficient alternative to subcutaneous methylnaltrexone for treatment of OIC in the hospital setting.
Sparsity Preserving Discretization With Error Bounds (2019)

Typically when designing distributed controllers it is assumed that the state-space model of the plant consists of sparse matrices. However, in the discrete-time setting, if one begins with a continuous-time model, the discretization process annihilates any sparsity in the model. In this work we propose a discretization procedure that maintains the sparsity of the continuous-time model. We show that this discretization out-performs a simple truncation method in terms of its ability to approximate the "ground truth" model. Leveraging results from numerical analysis we are also able to upper-bound the error between the dense discretization and our method. Furthermore, we show that in a robust control setting we can design a distributed controller on the approximate (sparse) model that stabilizes the dense ground truth model.
Blood oxygenation in buried flaps: a bi-layer reconstruction (2019)

International audience
Rigid‐rod polyelectrolytes based on poly(p‐phenylene sulfonic acid) (1996)

Abstract The synthesis and characterization of polyelectrolytes, composed of a shape persistent poly(p‐phenylene) backbone with regularly attached sulfonic acid‐ and n‐alkyl residues, is described. Polymers were obtained by Pd‐catalyzed coupling of substituted p‐phenylene‐bis‐boronic acid esters with 2,5‐dibromobenzenesulfonates or 4,4′‐dibromodiphenyl‐2,2′‐disulfonates, followed by saponification of the sulfonates. The polymers were found to have number average contour lengths ( L n ) betwen 23 and 155 nm. The polymer sulfonic acids behave as strong acids and are soluble in water as their tetramethylammonium salts. The concentration dependence of the viscosity of aqueous solutions of the salts does not follow the behavior seen for conventional polyelectrolytes. The polymers show lyotropic behavior at low to moderate concentrations. Polymers with long alkyl substituents, if spread as monolayers on a Langmuir trough and subject to the Langmuir‐Blodgett technique, give LB‐multi‐layers, which have been characterized by X‐ray reflectometry. As a model compound, sodium 4,4″‐dimethyl‐1,1′:4′,1″‐terphenyl‐2′‐sulfonate was obtained as single crystal and its X‐ray structure is described.