gebhart/patrepeval huggingface dataset:
Percutaneous coronary intervention during the COVID-19 pandemic in Japan: Insights from the nationwide registration data (2022)

The J-PCI registry is a registry led and supported by the Japanese Association of Cardiovascular Intervention and Therapeutics. The present study was supported by the Grant-in-Aid from the Ministry of Health and Labour (No. 20IA2002 and 21FA1015), the Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (KAKENHI; No. 21K08064), and the Japan Agency for Medical Research and Development (No. 17ek0210097h000).
Hierarchical polygon tiling with coverage masks (1996)

Article Free Access Share on Hierarchical polygon tiling with coverage masks Author: Ned Greene Apple Computer, 1 Infinite Loop, Cupertino, CA Apple Computer, 1 Infinite Loop, Cupertino, CAView Profile Authors Info & Claims SIGGRAPH '96: Proceedings of the 23rd annual conference on Computer graphics and interactive techniquesAugust 1996 Pages 65–74https://doi.org/10.1145/237170.237207Online:01 August 1996Publication History 63citation994DownloadsMetricsTotal Citations63Total Downloads994Last 12 Months19Last 6 weeks9 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
A large imaging array in Ka band with a substrate integrated waveguide Pillbox beamformer (2014)

A novel multiple beam antenna is proposed in Ka band. It consists of a dual reflector imaging configuration magnifying a reconfigurable phased array of smaller size, that produce a 2D coverage of multiple spot beams with a quasi-optical beamformer made of Pillbox 1D beamformers.
A Study on the Effect of Driver Model Parameters on the Performance of Driver-Vehicle-Road Closed-Loop System (2013)

The concept of DODF and other two evaluation indices based on DODF were proposed. Based on the optimal preview acceleration driver model, the effect of driver model parameters on the performance of driver-vehicle-road closed-loop system was studied by the closed-loop system simulation. The results show that the preview time of a driver who has good driving habits should be always larger than a certain value T P 0 , the increase of both nerve delay time t d and muscle lag time T h lead to the increase of T P 0 , and t d has more effect on T P 0 than T h does. The increase of both t d and T h lead to the decrease of DODF, and t d has more effect on DODF than T h does. Furthermore, the increase of both t d and T h also lead to the increase of both tracking index J EM and driving load index T CM , t d has more effect on J EM than T h does, and T h has more effect on T CM than t d does.
DO-MS: Data-Driven Optimization of Mass Spectrometry Methods (2019)

Abstract The performance of ultrasensitive LC-MS/MS methods, such as Single-Cell Proteomics by Mass Spectrometry (SCoPE-MS), depends on multiple interdependent parameters. This interdependence makes it challenging to specifically pinpoint bottlenecks in the LC-MS/MS methods and approaches for resolving them. For example, low signal at MS2 level can be due to poor LC separation, ionization, apex targeting, ion transfer, or ion detection. We sought to specifically diagnose such bottlenecks by interactively visualizing data from all levels of bottom-up LC-MS/MS analysis. Many search engines, such as MaxQuant, already provide such data, and we developed an open source platform for their interactive visualization and analysis: Data-driven Optimization of MS (DO-MS). We found that in many cases DO-MS not only specifically diagnosed bottlenecks but also enabled us to rationally optimize them. For example, we used DO-MS to diagnose poor sampling of the elution peak apex and to optimize it, which increased the efficiency of delivering ions for MS2 analysis by 370%. DO-MS is easy to install and use, and its GUI allows for interactive data subsetting and high-quality figure generation. The modular design of DO-MS facilitates customization and expansion. DO-MS is available for download from GitHub: github.com/SlavovLab/DO-MS
Multidisciplinary Treatment of a Large Cerebral Dural Arteriovenous Fistula Using Embolization, Surgery, and Radiosurgery (2008)

Dural arteriovenous fistulae are rare lesions composed of abnormal connections between meningeal arteries and the dural sinuses or lepto-meningeal veins. Treatment is challenging because of the small size and wide distribution of the myriad sites of fistulous connection. We present a case of a dural arteriovenous fistula presenting with visual deterioration, pulsatile tinnitus, and intracranial hypertension that was successfully treated with a multidisciplinary approach combining angiographic, surgical, and radiosurgical intervention. This is one of the largest of these formidable lesions treated in this fashion that has been reported.
Inhibition of Drp1/Fis1 interaction slows progression of amyotrophic lateral sclerosis (2018)

Bioenergetic failure and oxidative stress are common pathological hallmarks of amyotrophic lateral sclerosis (ALS), but whether these could be targeted effectively for novel therapeutic intervention needs to be determined. One of the reported contributors to ALS pathology is mitochondrial dysfunction associated with excessive mitochondrial fission and fragmentation, which is predominantly mediated by Drp1 hyperactivation. Here, we determined whether inhibition of excessive fission by inhibiting Drp1/Fis1 interaction affects disease progression. We observed mitochondrial excessive fragmentation and dysfunction in several familial forms of ALS patient-derived fibroblasts as well as in cultured motor neurons expressing SOD1 mutant. In both cell models, inhibition of Drp1/Fis1 interaction by a selective peptide inhibitor, P110, led to a significant reduction in reactive oxygen species levels, and to improvement in mitochondrial structure and functions. Sustained treatment of mice expressing G93A SOD1 mutation with P110, beginning at the onset of disease symptoms at day 90, produced an improvement in motor performance and survival, suggesting that Drp1 hyperactivation may be an attractive target in the treatment of ALS patients.
On learning texture edge detectors (2002)

Texture is an inherently non-local image property. All common texture descriptors, therefore, have a significant spatial support which renders classical edge detection schemes inadequate for the detection of texture boundaries. In this paper we propose a novel scheme to learn filters for texture edge detection. Textures are defined by the statistical distribution of Gabor filter responses. Optimality criteria for detection reliability and localization accuracy are suggested in the spirit of Canny's edge detector. Texture edges are determined as zero crossings of the difference of the two a posteriori class distributions. An optimization algorithm is designed to determine the best filter kernel according to the underlying quality measure. The effectiveness of the approach is demonstrated on texture mondrians composed from the Brodatz album and a series of synthetic aperture radar (SAR) imagery. Moreover, we indicate how the proposed scheme can be combined with snake-type algorithms for prior-knowledge driven boundary refinement and interactive annotation.
Reduced phosphorylation of ribosomal protein S6 is associated with sensitivity to MEK inhibition in gastric cancer cells (2016)

Gastric cancer (GC) is characterized by amplifications of receptor tyrosine kinases (RTK) and KRAS, therefore, targeting of the RTK/KRAS downstream pathways could help to broaden the applicability of molecular targeted therapy for GC. We assembled a panel of 48 GC cell lines and screened predictors of responsiveness to inhibition of the RAF/MEK/ERK pathway, one of the RTK/KRAS downstream pathways. We found that GC cells with MET amplification or KRAS mutation, but not amplification, tended to be sensitive to MEK inhibition. However, several cell lines without RTK/KRAS alterations also showed high sensitivity to MEK inhibition. We then focused on the phosphorylation of RTK/KRAS downstream molecules to screen for predictors' sensitivity to MEK inhibition. We found that the phosphorylation level of mammalian target of rapamycin complex 1 (mTORC1) downstream molecules, including p70S6K, 4EBP1, and S6, was significantly associated with sensitivity to MEK inhibition in GC cells (P < 0.05), suggesting that mTORC1 activity is related to the sensitivity to MEK inhibition. Furthermore, the change in mTORC1 activity after MEK inhibition was also significantly associated with this sensitivity (P < 0.001). Among the mTORC1 downstream molecules, the change in S6 phosphorylation (pS6) showed the most significant correlation with sensitivity. Using xenograft models derived from highly sensitive and resistant cell lines, we found specific reduction of pS6 in xenografts from highly sensitive cell lines after 6 h of treatment with an MEK inhibitor. Thus, our data suggest the potential clinical applicability of an MEK inhibitor for a proportion of GC patients who could be selected on the basis of pS6 change after MEK inhibition.
Performance trade-off between serrated edge and blended rolled edge compact range reflectors (1996)

The performance trade-off between serrated edge and blended rolled edge compact range reflectors is investigated. The edge diffracted fields which contribute to stray signals in the quiet zone have to be minimized. Consequently, an iterative approach has been developed to design serrated edges such that the edge diffracted rays from the serrations can be kept as far away as possible from the desired quiet zone area. Performance of various designs based on the number and size of serrations have been studied using a physical theory of diffraction solution. In addition, an optimized blended rolled edge design with the same size as the serrated edge reflector has also been evaluated for comparison. Finally, numerical results are presented in this paper to address the performance trade-off issue among the various designs. It is clearly shown from this study that the blended rolled edge reflector performs significantly better, which should offset the increased cost needed to construct a rolled edge reflector versus a serrated one.
Retinoid agonist Am80-enhanced neutrophil bactericidal activity arising from granulopoiesis in vitro and in a neutropenic mouse model (2012)

Despite advances in the therapeutic use of recombinant granulocyte colony-stimulating factor (G-CSF) to promote granulopoiesis of human hematopoietic stem cells (HSCs), neutropenia remains one of the most serious complications of cancer chemotherapy. We discovered that retinoid agonist Am80 (tamibarotene) is more potent than G-CSF in coordinating neutrophil differentiation and immunity development. Am80-induced neutrophils (AINs) either in vitro or in neutropenic mouse model displayed strong bactericidal activities, similar to those of human peripheral blood neutrophils (PBNs) or mouse peripheral blood neutrophils (MPBNs) but markedly greater than did G-CSF–induced neutrophils (GINs). In contrast to GINs but similar to PBNs, the enhanced bacterial killing by AINs accompanied both better granule maturation and greater coexpression of CD66 antigen with the integrin β2 subunit CD18. Consistently, anti-CD18 antibody neutralized Am80-induced bactericidal activities of AINs. These studies demonstrate that Am80 is more effective than G-CSF in promoting neutrophil differentiation and bactericidal activities, probably through coordinating the functional interaction of CD66 with CD18 to enhance the development of neutrophil immunity during granulopoiesis. Our findings herein suggest a molecular rationale for developing new therapy against neutropenia using Am80 as a cost-effective treatment option.
Model-based segmentation of brain tissue and tumor (2002)

Summary form only given. Combining image segmentation based on statistical classification with a geometric prior shows a significant increase in robustness and reproducibility. Using a probabilistic geometric model of sought structures helps with initialization of probability density functions and defines spatial constraints. A strong spatial prior, however, prevents segmentation of structures that are not part of the model. In practical applications presenting pathology, e.g. brain tumors, we encounter the presentation of new objects not modelled by a statistical atlas of healthy anatomy. We developed an extension to an existing expectation maximization segmentation (EM) algorithm that modifies a probabilistic brain atlas with individual subject's information which results in an automatic, atlas-based classification of healthy tissue and pathology. Object segmentation requires spatial grouping of classified voxels. For tumors, we use the geometric model of blobby shaped objects and use region-competition level-set evolution. The statistical classification of the classification step serves as a probabilistic measure for object and background. The geodesic snake, initialized by the noisy tumor classification and locally driven by object/background probabilities, generates smooth, blobby structures presenting tumors. The new brain and tumor segmentation method has been tested on five cases presenting different tumor types and shapes. A preliminary validation compared these segmentations with manual expert's results.
Progression from Mild to Pronounced MCI Is Not Associated with Cerebrospinal Fluid Biomarker Deviations (2011)

As expected, biomarker deviations predicted progression from MCI to dementia. Contrary to our hypothesis, progression from very mild MCI to more pronounced MCI was not reflected by biomarker deviations. The results suggest that the measured biomarkers are not early disease markers, or alternatively Alzheimer or vascular pathology is not the underlying cause in this patient group.
Oxidation of pyrrole with p-benzoquinone to semiconducting products and their application in electrorheology (2018)

A low-molecular-weight organic semiconducting material was prepared by the redox interaction between pyrrole and <italic>p</italic>-benzoquinone.
Temperature Distribution of Piston in High Speed Diesel Engine (1979)

従来重要でありながら測定が困難なために熱的関係が明確でなかった高速ディーゼル機関の実動時のピストンリング、ピストンの温度分布を熱電対により直接詳細に測定することにより、ピストンリング内の温度分布およびその熱流れを、第1、第2、オイルおよびテーパリングについて、さらにピストンの受熱量と各部への放熱割合を明確にし、ピストン、ピストンリングおよびシリンダの相互熱流れに関する興味ある関係がわかった。
SAR images refocusing and scattering center detection for infrastructure monitoring (2014)

Infrastructure monitoring applications can require the tracking of slowly moving points of a certain structure. Given a certain point from a structure to be monitored, in the context of available SAR products where the image is already focused in a slant range — azimuth grid, it is not obvious if this point is the scattering center, if it is in layover or if it is visible from the respective orbit. This paper proposes a refocusing procedure of SAR images on a set of measured points among with a 4D tomography based scattering center detection. The refocusing procedure consists of an azimuth defocusing followed by a modified back-projection on the given set of points. The presence of a scattering center at the given positions is detected by computing the local elevation-velocity plane for each point and testing if the main response is at zero elevation. The refocusing and scattering center detection algorithm is validated on real data acquired with the TerraSAR-X satellite during March-June 2012. The mean displacement velocities of the detected scatterers show good agreement with the in-situ measurements.
Small Cell Lung Cancer from Traditional to Innovative Therapeutics: Building a Comprehensive Network to Optimize Clinical and Translational Research (2020)

Small cell lung cancer (SCLC) is an aggressive, complex disease with a distinct biology that contributes to its poor prognosis. Management of SCLC is still widely limited to chemotherapy and radiation therapy, and research recruitment still poses a considerable challenge. Here, we review the current standard of care for SCLC and advances made in utilizing immunotherapy. We also highlight research in the development of targeted therapies and emphasize the importance of a team-based approach to make clinical advances. Building an integrative network between an academic site and community practice sites optimizes biomarker and drug target discovery for managing and treating a difficult disease like SCLC.
[Long-term surveillance after basic elimination of bancroftian filariasis]. (1993)

The longitudinal and cross-sectional systemic surveillance have been conducted for 9-11 consecutive years in six counties (cities) of Guangxi Zhuang Autonomous Region after basic elimination of bancroftian filariasis. The two different control regimens had been used with DEC selective treatment followed by mass treatment of all persons and selective treatment followed by taking DEC medicated salt. During the former 6 years, residual microfilaremia cases could still be detected; whereas during the latter 5 years, no microfilaremia cases could be detected at all. The natural infection of vector mosquitoes showed negative. The positive rate of antibody in the populations was reduced to 1.4-5.5% detected by IFAT, reaching to the level of local non-endemic areas. The result indicated that the transmission of filariasis in these areas has been blocked. The authors suggested that a period of 10 years might be appropriate for surveillance after basic elimination of bancroftian filariasis.
Effect of band structure on etch-stop layers in the photoelectrochemical etching of GaAs/AlGaAs semiconductor structures (1993)

We have examined the limitations on selectivity of thin dopant-selective and band-gap-selective etch-stop layers in the photoelectrochemical (PEC) etch process. The ultimate selectivity of one layer from an underlying layer is affected not only by differences in material composition, but also by the sequencing of the layers within the structure which will determine the distribution of the photogenerated carriers. Three semiconductor structures with variations in both doping and band gap were etched to demonstrate this effect. A He-Ne laser (633 nm) and a tunable Ti/sapphire laser (690–830 nm) were used as light sources and a (1:20) HCl:H2O solution was the electrolyte.
Sharing health-care records over the Internet (2001)

Presents a novel approach to sharing electronic health-care records that leverages the Internet and the World Wide Web, developed as part of two European Commission-funded projects, Synapses and SynEx. The approach provides an integrated view of patient data from heterogeneous, distributed information systems and presents it to users electronically. Synapses and SynEx illustrate a generic approach in applying Internet technologies for viewing shared records, integrated with existing health computing environments. Prototypes have been validated in a variety of clinical domains and health-care settings.
A method for continual monitoring of bone resorption in rats: evidence for a diurnal rhythm (1990)

A method has been developed to monitor bone resorption (BR) based on the urinary excretion of [3H]tetracycline ([3H]TC) from chronically prelabeled rats. This is possible because the [3H]TC released from bone has been found to be in a form that is not or only poorly bound to apatite and thus not reincorporated into newly formed bone. When BR was increased by means of dietary calcium restriction, parathyroid hormone (PTH) infusion, or retinoid injections, urinary [3H]TC doubled. When BR was inhibited by feeding calcium supplements or administration of dichloromethylenebisphosphonate, [3H]TC excretion dropped by two-thirds. Thyroparathyroidectomy inhibited [3H]TC excretion by one-third. The results obtained with this technique are therefore similar to those obtained with other methods such as 45Ca kinetics. The effect of dietary manipulations on BR was detected within 6 h of changing diet. Furthermore, a strong diet-dependent but PTH- and calcitonin-independent diurnal rhythm in BR was found. By use of this technique, bone resorption can be assessed continuously over long periods, and the acute regulation of bone resorption can be studied for the first time.
Calvin Massey, Gentleman Farmer (2017)

[Excerpt] “So much of Calvin’s work was intelligible as work about freedom and independence, preventing aggregations of government power that threatened individual freedom. Calvin didn’t love federalism because he had a romanticized view of statehood, he believed in it because he thought centralized power in the federal government was a bigger threat to individual freedom than states were. In most states, a tin-pot governor and amateur hour legislators just aren’t going to be as effective at coercing beliefs as an Executive Branch that contains the U.S. Treasury, the Justice Department, the FBI, and the CIA, not to mention the Pentagon and the Department of Education to tell us all how to teach our classes. Some colleagues thought that Calvin was a libertarian, and I honestly can’t remember whether he embraced that label or not, but he sure as hell didn’t want the government telling people what to think or how to behave in their private lives.”
Biosiglive: an Open-Source Python Package for Real-timeBiosignal Processing (2023)

biosiglive aims to provide a simple and efficient way to access and process biomechanical data in real time.It was conceived as user-friendly software aimed for both non-expert and expert programmers.The library uses interfaces to access data from several sources, such as motion capture software or any Python software development kit (SDK).Some interfaces are already implemented for Vicon Nexus motion capture (Oxford, UK) and Delsys electromyography SDK (EMG) (Boston, USA).That say, any additional interface can be added as custom interface using the abstract class.biosiglive was designed for biosignals, therefore, existing classes represent data collected from standard acquisition systems in biomechanics, such as markers for motion capture or EMG.Methods are available to process in real-time any input signal.Data can be saved in a binary file at each time frame to avoid any data loss in case of system shutdown.Data can also be displayed using the LivePlot class, which is based on PyQtGraph (C++ core) and allows, therefore, fast real-time displaying.Finally, 'biosiglive' was conceived as a flexible real-time data processing and streaming tool adaptable to various set-ups, software, and systems.Therefore, a TCP/IP connection module was implemented to send data to a distant port to be used by any other system.
NAT2 Acetylator Genotypes Confer No Effect on the Risk of Developing Adult Acute Leukemia (2001)

An increased risk of developing acute leukemia has been associated with exposure to tobacco smoke [(1)][1] , a known source of carcinogenic NAT2[2][2] substrates such as arylamines and hydroxylamines. Polymorphic status at the NAT2 locus may mediate this risk. To address whether acetylator status