gebhart/patrepeval huggingface dataset:
Parkin Modulates Endosomal Organization and Function of the Endo-Lysosomal Pathway (2016)

Mutations in PARK2 (parkin), which encodes Parkin protein, an E3 ubiquitin ligase, are associated with autosomal recessive early-onset Parkinson's disease (PD). While several studies implicated Parkin in the regulation of mitophagy and proteasomal degradation, the precise mechanism leading to neurodegeneration upon Parkin loss of function remains incompletely understood. In this study, we found that Parkin modulates the endocytic pathway through the regulation of endosomal structure and function. We showed that loss of Parkin function led to decreased endosomal tubulation and membrane association of vesicle protein sorting 35 (VPS35) and sorting nexin 1 (SNX1), as well as decreased mannose 6 phosphate receptor (M6PR), suggesting the impairment of retromer pathway in Parkin-deficient cells. We also found increased formation of intraluminal vesicles coupled with enhanced release of exosomes in the presence of mutant Parkin. To elucidate the molecular mechanism of these alterations in the endocytic pathway in Parkin-deficient cells, we found that Parkin regulates the levels and activity of Rab7 by promoting its ubiquitination on lysine 38 residue. Both endogenous Rab7 in Parkin-deficient cells and overexpressed K38 R-Rab7 mutant displayed decreased effector binding and membrane association. Furthermore, overexpression of K38R-Rab7 in HEK293 cells phenocopied the increased secretion of exosomes observed in Parkin-deficient cells, suggesting that Rab7 deregulation may be at least partially responsible for the endocytic phenotype observed in Parkin-deficient cells. These findings establish a role for Parkin in regulating the endo-lysosomal pathway and retromer function and raise the possibility that alterations in these pathways contribute to the development of pathology in Parkin-linked Parkinson's disease.
Radiation tolerance of NMOS technology on indium phosphide (1984)

Preliminary unbiased total-dose gamma irradiation results on InP MIS structures are reported. Using discrete FET and MIS diode samples as well as CCD and ring-oscillator (RO) integrated circuits, it is concluded that, under the present test conditions, no changes in the performance of these devices can be attributed to the gamma flux to doses as high as 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">8</sup> rad.
BASH-GN: A new machine learning derived questionnaire for screening obstructive sleep apnea (2022)

Abstract Purpose This study aims to develop a machine learning based questionnaire (BASH-GN) to classify obstructive sleep apnea (OSA) risk by considering risk factor subtypes. Methods A total of 4,527 participants that met study inclusion criteria were selected from Sleep Heart Health Study Visit 1 (SHHS 1) database. Another 1,120 records from Wisconsin Sleep Cohort (WSC) served as an independent test data set. Participants with an apnea hypopnea index (AHI) ≥ 15/h were considered as high OSA risk. Potential risk factors were ranked using mutual information between each factor and the AHI, and only the top 50% were selected. We classified the subjects into 2 different groups, low- and high phenotype groups, according to their risk scores. We then developed the BASH-GN, a machine learning based questionnaire that consists of two logistic regression classifiers for the 2 different subtypes of OSA risk prediction. Results We evaluated the BASH-GN on the SHHS 1 test set (n = 1237) and WSC set (n = 1120) and compared its performance with four commonly used OSA screening questionnaires, the Four-Variable, Epworth Sleepiness Scale, Berlin, and STOP-BANG. The model outperformed these questionnaires on both test sets regarding the area under the receiver operating characteristic (AUROC) and the area under the precision-recall curve (AUPRC). The model achieved AUROC (SHHS 1: 0.78, WSC: 0.76) and AUPRC (SHHS 1: 0.72, WSC: 0.74), respectively. The questionnaire is available at: https://c2ship.org/bash-gn Conclusion Considering OSA subtypes when evaluating OSA risk can improve the accuracy of OSA screening.
An Aspect-Oriented Approach to Privacy-Aware Access Control (2007)

This paper concerns the problem of enhancing enterprise applications with a modular mechanism for enforcing privacy policies on personal data. We propose to use aspect-oriented programming and address the involved issues from the perspective of extending fine-grained access control with privacy concerns. An aspect framework for enforcing access control in Struts-based Web applications is extended with fine-grained privacy protection mechanisms that make the aspects privacy aware. The proposed mechanisms are loosely coupled with the underlying application. It is thus easy to adapt them and employ them to migrate existing applications.
Plasma tissue-type plasminogen activator is associated with lipoprotein(a) and clinical outcomes in hospitalized patients with COVID-19 (2023)

High Lp(a) concentration provides a possible explanation for low endogenous tPA enzymatic activity, and poor clinical outcomes in patients with COVID-19.
An electrically-thin, two-pole, bandpass radome (2004)

A two-pole bandpass radome is comprised of an inductive ground plane with symmetric capacitive FSS structures equally spaced on either side. Capacitive patches in these two FSS structures are connected with the ground plane by virtue of plated through holes. Spurious modes are suppressed over a very broad frequency band between the desired passband and the parasitic resonance of the FSS patches, which can be up to an order of magnitude in ratio due to the relatively small size of the patches. Furthermore, the total radome thickness can be designed to be less than /spl lambda//sub 0//50 at the fundamental passband. An L-band example is fabricated and tested.
14‐Methylpentadecano‐15‐lactone (Muscolide): A New Macrocyclic Lactone from the Oil of Angelica archangelica L. (2005)

The chemical composition of seed and root oils from Angelica archangelica L. was investigated. Analyses were performed by GC/MS and GC using two columns of different polarities (polyethylene glycol (DB-Wax) and 5% phenyl/95% polydimethylsiloxane (HP-5)), for the separation of several co-eluting components. A total of 58 compounds were identified, accounting for 96.3% (seed) and 93.5% (root) of the oils, respectively. A high content of β-phellandrene (74.7%) was found in Angelica seed oil. Root oil contained a larger amount of macrocyclic lactones (1.3%) in comparison to the seed oil (0.4%). Different harvest dates produced only slight changes in the root-oil composition. In root oil harvested in summer, the β-phellandrene content increased by ca. 36%, but no significant changes in the relative compositions of other components were observed. Fresh root oils were collected in five fractions (constant time intervals) during steam distillation (see Table). The highest-boiling fraction contained 9.3% of macrocyclic lactones such as tridecano-13-lactone (5.0%), 12-methyltridecano-13-lactone (0.4%), tetradecano-14-lactone (0.1%), pentadecano-15-lactone (3.5%), 14-methylpentadecano- 15-lactone (1; trace), hexadecano-16-lactone (trace), and heptadecano-17-lactone (0.2%). This is the first report of the occurrence of 14-methylpentadecano-15-lactone (muscolide; 1) in a natural product.
Synthesis, Processing, and Characterization of Inorganic-Organic Hybrid Cross-Linked Silica, Organic Polyimide, and Inorganic Aluminosilicate Aerogels (2014)

As aerospace applications become ever more demanding, novel insulation materials with lower thermal conductivity, lighter weight and higher use temperature are required to fit the aerospace application needs. Having nanopores and high porosity, aerogels are superior thermal insulators, among other things. The use of silica aerogels in general is quite restricted due to their inherent fragility, hygroscopic nature, and poor mechanical properties, especially in extereme aerospace environments. Our research goal is to develop aerogels with better mechanical and environmental stability for a variety of aeronautic and space applications including space suit insulation for planetary surface missions, insulation for inflatable structures for habitats, inflatable aerodynamic decelerators for entry, descent and landing (EDL) operations, and cryotank insulation for advance space propulsion systems. Different type of aerogels including organic-inorganic polymer reinforced (hybrid) silica-based aerogels, polyimide aerogels and inorganic aluminosilicate aerogels have been developed and examined.
Effect of contrast enhancement on the measurement of carotid arterial lumen and wall volume using MRI (2006)

Gd CE causes a significant increase in the apparent volume of the carotid wall throughout multiple carotid artery locations, which may be associated with improved visibility or neovascularization.
An Airborne SAR Moving Target Imaging and Motion Parameters Estimation Algorithm With Azimuth-Dechirping and the Second-Order Keystone Transform Applied (2015)

In this paper, we propose an algorithm for airborne SAR moving target imaging and motion parameters estimation in Doppler ambiguity situation with azimuth-dechirping and the second-order keystone transform (SOKT) applied. In this algorithm, we use a third-order phase model for the echo signal, and after the compensation of third-order phase, the moving target can be symmetrically focused in azimuth. This algorithm has five major steps. The azimuth-dechirping is conducted to eliminate the Doppler ambiguity. The SOKT is conducted to correct the range curvature. The Radon transform is applied to estimate the trajectory slope for range walk correction and the across-track velocity estimation. The fractional Fourier transform (FrFT) is utilized to estimate the Doppler rate for estimating the along-track velocity. The moving target is focused after azimuth compression and third-order phase compensation. Both simulation and real SAR data are processed to validate the proposed algorithm.
The Risk Factors and Environm ental Risk Prediction during the Production of Yellow Phosphorus (2014)

Phosphorus is an important chemical raw material of economy. There are several risk factors in the entire production process of yellow phosphorus. The health of the production staff was greatly endangered by the toxic and harmful substances. The generation of risk factors was analyzed during the yellow phosphorus production and its harm was discussed,and several toxic and harmful substances were tested for a number of phosphorus manufacturing enterprises. The environmental risks of P2O5 in phosphorus pollution sources were scientifically predicted on the first time.
Polyviologen Hydrogel with High-Rate Capability for Anodes toward an Aqueous Electrolyte-Type and Organic-Based Rechargeable Device (2013)

A highly cross-linked polyviologen hydrogel, poly(tripyridiniomesitylene) (PTPM), has been designed as an anode-active material. It displays a reversible two-electron redox capability at -0.4 and -0.8 V vs Ag/AgCl in an aqueous electrolyte. The PTPM layer coated on a current collector by electropolymerization via a 4-cyanopyridinium electro-coupling reaction demonstrates a rapid charging-discharging reaction with a redox capacity comparable to that obtainable using the formula weight-based theoretical density, because of the combination of the redox-active viologen moieties built into the hydrogel. A test cell that has been fabricated using the developed PTPM anode, a poly(2,2,6,6-tetramethylpiperidinyloxy-4-yl acrylamide) (PTAm)-based cathode, and an aqueous electrolyte exhibits a discharging voltage of 1.1 and 1.5 V, and has proven its ability to be recharged more than 2000 times.
7 Pandemic situation and safe transportation, storage, and distribution for food catering and deliveries (2021)

Pandemic situation and safe transportation, storage, and
The Basic Pharmacology of Ticlopidine and Clopidogrel (1993)

Ticlopidine and clopidogrel are two thienopyridines with potent and apparently irreversible platelet inhibitory properties. The antiplatelet effects are mainly directed against ADP-induced stimulation of platelet function, in particular ADP-induced inhibition of adenylyl cyclase stimulation. There is evidence for additional effects, including inhibition of agonist-induced intracellular Ca(++) mobilization, interference with GpIIb/IIIa receptor/agonist interaction and inhibition of α-granule secretion. However, these actions are probably secondary to the ADP-antagonistic action. Thienopyridines do not directly interfere with arachidonic acid metabolism. The substances are inactive in vitro and have to undergo some form of bioactivation in vivo which requires 3 to 5 days of treatment for a maximum effect. The nature of the postulated active metabolite(s) is still unknown. From a pharmacological point of view, thienopyridines may be considered interesting alternatives to acetylsalicylic acid with particular value in shear-stress-mediated platelet activation, for example in prevention of acute thrombembolic risk in injury-related vessel stenosis.
ChemInform Abstract: SYNTHESIS OF PERFLUOROPOLYETHERS BY DIRECT FLUORINATION; A NOVEL PREPARATION FOR PERFLUORO(POLYPROPYLENE OXIDE) ETHERS AND PERFLUORO(POLYMETHYLENE OXIDE) ETHERS (1981)

Abstract Eine Behandlung von Polypropylen (I) (Öl) mit He.‐verd.
Effect of gallium aluminium arsenide diode laser therapy on Porphyromonas gingivalis in chronic periodontitis: a randomized controlled trial (2015)

GaAlAs diode laser irradiation of diseased periodontal pockets at 685 nm and 1.6 J cm<sup>-2</sup> seemed to be an effective adjuvant to mechanical instrumentation to treat chronic periodontitis.
Rational Polypharmacology: Systematically Identifying and Engaging Multiple Drug Targets To Promote Axon Growth (2015)

Mammalian central nervous system (CNS) neurons regrow their axons poorly following injury, resulting in irreversible functional losses. Identifying therapeutics that encourage CNS axon repair has been difficult, in part because multiple etiologies underlie this regenerative failure. This suggests a particular need for drugs that engage multiple molecular targets. Although multitarget drugs are generally more effective than highly selective alternatives, we lack systematic methods for discovering such drugs. Target-based screening is an efficient technique for identifying potent modulators of individual targets. In contrast, phenotypic screening can identify drugs with multiple targets; however, these targets remain unknown. To address this gap, we combined the two drug discovery approaches using machine learning and information theory. We screened compounds in a phenotypic assay with primary CNS neurons and also in a panel of kinase enzyme assays. We used learning algorithms to relate the compounds' kinase inhibition profiles to their influence on neurite outgrowth. This allowed us to identify kinases that may serve as targets for promoting neurite outgrowth as well as others whose targeting should be avoided. We found that compounds that inhibit multiple targets (polypharmacology) promote robust neurite outgrowth in vitro. One compound with exemplary polypharmacology was found to promote axon growth in a rodent spinal cord injury model. A more general applicability of our approach is suggested by its ability to deconvolve known targets for a breast cancer cell line as well as targets recently shown to mediate drug resistance.
A brief overview of speech enhancement with linear filtering (2014)

Abstract In this paper, we provide an overview of some recently introduced principles and ideas for speech enhancement with linear filtering and explore how these are related and how they can be used in various applications. This is done in a general framework where the speech enhancement problem is stated as a signal vector estimation problem, i.e., with a filter matrix, where the estimate is obtained by means of a matrix-vector product of the filter matrix and the noisy signal vector. In this framework, minimum distortion, minimum variance distortionless response (MVDR), tradeoff, maximum signal-to-noise ratio (SNR), and Wiener filters are derived from the conventional speech enhancement approach and the recently introduced orthogonal decomposition approach. For each of the filters, we derive their properties in terms of output SNR and speech distortion. We then demonstrate how the ideas can be applied to single- and multichannel noise reduction in both the time and frequency domains as well as binaural noise reduction.
Linearization of multi-output logic functions by ordering of the autocorrelation values (2007)

The paper deals with the problem of linear decomposition of a system of Boolean functions. A novel analytic method for linearization, by reordering the values of the autocorrelation function, is presented. The computational complexity of the linearization procedure is reduced by performing calculations directly on a subset of autocorrelation values rather than by manipulating the Boolean function in its initial domain. It is proved that unlike other greedy methods, the new technique does not increase the implementation cost. That is, it provides linearized functions with a complexity that is not greater than the complexity of the initial Boolean functions. Experimental results over standard benchmarks and random Boolean functions demonstrate the efficiency of the proposed procedure in terms of the complexity measure and the execution time.
Synthesis of Carbocyclic 2',3'-Dideoxy-2'-C-hydroxymethyl Nucleosides as Potential Inhibitors of HIV (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of Carbocyclic 2',3'-Dideoxy-2'-C-hydroxymethyl Nucleosides as Potential Inhibitors of HIVAsa Rosenquist, Ingemar Kvarnstroem, Stefan C. T. Svensson, Bjoern Classon, and Bertil SamuelssonCite this: J. Org. Chem. 1994, 59, 7, 1779–1782Publication Date (Print):April 1, 1994Publication History Published online1 May 2002Published inissue 1 April 1994https://doi.org/10.1021/jo00086a031Request reuse permissionsArticle Views159Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (538 KB) Get e-Alertsclose Get e-Alerts
Emulsification Methods for Perfluorochemicals (1988)

AbstractA comparison of emulsification methods for novel perfluorochemical (PFC) emulsions for biological uses related to oxygen transport has been made. The emulsions were based on perfluorodecalin (FDC) and contained small quantities of polycyclic, perfluorinated, higher boiling point oil (HBPO) additives to stabilise against the process of molecular diffusion known as Ostwald ripening. Emulsification methods studied include sonication and homogenization which produced emulsions having similar particle size distributions. However, sonication generated fluoride (F-) ions which may have adverse physiological effects.
Code migration through transformations (2010)

One approach to dealing with spiraling maintenance costs, manpower shortages and frequent breakdowns for legacy code is to "migrate" the code into a new platform and/or programming language. The objective of this paper is to explore the feasibility of semi-automating such a migration process in the presence of performance and other constraints for the migrant code. In particular, the paper reports on an experiment involving a medium-size software system written in PL/IX. Several modules of the system were migrated to C++, first by hand and then through a semiautomatic tool. After discovering that the migrant code was performing up to 50% slower than the original, a second migration effort was conducted which improved the performance of the migrant code substantially. The paper reports on the transformation techniques used by the transformation process and the effectiveness of the prototype tools that were developed. In addition, the paper presents preliminary results on the evaluation of the experiment.
Test of the Epstein−Plesset Model for Gas Microparticle Dissolution in Aqueous Media:  Effect of Surface Tension and Gas Undersaturation in Solution (2004)

The gas from a free air bubble will readily dissolve in water, driven by two main factors: the concentration (undersaturation) of dissolved gas in the aqueous solution and the surface tension of the gas bubble-water interface via a Laplace overpressure in the bubble that this creates. This paper experimentally and theoretically investigates each of these effects individually. To study the effects of surface tension, single- and double-chain surfactants were utilized to control and define interfacial conditions of the microbubble in saturated solution. To study the effect of undersaturation, solid distearoylphosphocholine lipid was utilized to coat the gas microparticle with, essentially, a wax monolayer and to achieve zero tension in the surface. The experimental work was performed using a micromanipulation technique that allows one to create and micromanipulate single air microparticles (5-50 microm radius range) in infinite dilution and to accurately record the size of the particle as it loses volume due to the dissolution process. The micropipet technique has shown to be an improvement over other previous attempts to measure dissolution time with a 3.2% average experimental error in gas microparticle dissolution time. An ability to study a gas microparticle in infinite dilution in an isotropic diffusion field is in line with the theoretical assumptions and conditions of the Epstein-Plesset model. The Epstein-Plesset model on average underpredicted the experimentally determined dissolution time by 8.6%, where the effect of surface tension was considered with a range of surface tensions from 72 down to 25 mN/m. The Epstein-Plesset model on average overpredicted the dissolution time by 8.2%, where the effect of undersaturation was considered for a microparticle with zero tension in the surface (zero Laplace pressure) and a range of gas saturations from 70% to 100%. Compared to previous attempts in the literature, this paper more appropriately and accurately tests the Epstein-Plesset model for the dissolution of a single microbubble and an air-filled microparticle in aqueous solution.
Oxidative Cyclization of β-Hydroxyenones with Palladium(II):  A Novel Entry to 2,3-Dihydro-4H-pyran-4-ones (2003)

[reaction: see text] A palladium(II)-mediated oxidative cyclization was found to be effective for the preparation of structurally diverse 2,3-dihydro-4H-pyran-4-ones from the corresponding beta-hydroxyenones. Attractive features of this transformation include the ready availability of the starting enones, the regiocontrol, and the easy access of enantiopure 2,3-dihydro-4H-pyran-4-one from the corresponding enantiopure enone.