gebhart/patrepeval huggingface dataset:
The v-Src SH3 Domain Binds Phosphatidylinositol 3'-Kinase (1993)

Fibroblasts transformed by v-src or by related oncogenes encoding activated tyrosine kinases contain elevated levels of polyphosphoinositides with phosphate at the D-3 position of the inositol ring, as a result of the activation of phosphatidylinositol (PI) 3'-kinase. v-src-transformed cells also contain increased levels of PI 3'-kinase activity immunoprecipitable with anti-phosphotyrosine antibodies; furthermore, PI 3'-kinase can be detected in association with the v-Src tyrosine kinase. To identify regions of v-Src that can interact with PI 3'-kinase, the v-Src SH2 and SH3 domains were expressed in bacteria and incubated with lysates of normal chicken embryo fibroblasts. In vitro, the v-Src SH3 domain, but not the SH2 domain, bound PI 3'-kinase in lysates of uninfected chicken embryo fibroblasts. Substitutions of two highly conserved SH3 residues implicated in ligand binding abolished the ability of the v-Src SH3 domain to associate with PI 3'-kinase. Furthermore, the v-Src SH3 domain bound in vitro to the amino-terminal region of the p85 alpha subunit of PI 3'-kinase. These results suggest that the v-Src SH3 domain may mediate an interaction between the v-Src tyrosine kinase and PI 3'-kinase, by direct binding to p85.
Phosphido-bridged mixed-metal (ruthenium/cobalt) compounds via the reaction of (arene)RuCl2(PPh2X) (X = H, Cl) with Co2(CO)8: x-ray structure of RuCo2(.mu.-PPh2)2(.mu.-CO)(CO)7 (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhosphido-bridged mixed-metal (ruthenium/cobalt) compounds via the reaction of (arene)RuCl2(PPh2X) (X = H, Cl) with Co2(CO)8: x-ray structure of RuCo2(.mu.-PPh2)2(.mu.-CO)(CO)7Rachid Regragui, Pierre H. Dixneuf, Nicholas J. Taylor, and Arthur J. CartyCite this: Organometallics 1984, 3, 7, 1020–1025Publication Date (Print):July 1, 1984Publication History Published online1 May 2002Published inissue 1 July 1984https://pubs.acs.org/doi/10.1021/om00085a010https://doi.org/10.1021/om00085a010research-articleACS PublicationsRequest reuse permissionsArticle Views111Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Evaluation of a Novel Barrier—Type Teat Dip Product Applied to Ewes Post-Weaning (1998)

Teats of 36 ewes (72 udder halves or teats) were dipped with an experimental barrier - type teat dip product to evaluate product persistency post weaning. Persistency was evaluated one to two times/day and scored positive if the teat end orifice was covered and protected. Persistency or the percentage of teats covered/protected at 36, 54, 72, 96, 132, and 156 hours was 100%, 93%, 89%, 63%, 35%, and 24% respectively. Ewes will be dipped again pre-lambing and both persistency and bacteriology (mastitis prevention) will be evaluated compared to 36 control ewes.
The Enantiomorphic Erythritol 4-Phosphates (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Enantiomorphic Erythritol 4-PhosphatesD. L. MacDonald, Hermann O. L. Fischer, and Clinton E. BallouCite this: J. Am. Chem. Soc. 1956, 78, 15, 3720–3722Publication Date (Print):August 1, 1956Publication History Published online1 May 2002Published inissue 1 August 1956https://pubs.acs.org/doi/10.1021/ja01596a046https://doi.org/10.1021/ja01596a046research-articleACS PublicationsRequest reuse permissionsArticle Views186Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Routing in Flying Ad Hoc Networks: A Comprehensive Survey (2020)

The use of unmanned aerial vehicles (UAVs) is attracting considerable interest in academic research, commercial, and military applications. Multi-UAV systems organized in an ad hoc fashion called a flying ad hoc network (FANET) can cooperatively and collaboratively accomplish complex missions more efficiently compared to single large UAV systems. However, the unique features of FANETs such as high mobility, low node density, and high frequency of topology changes introduce challenges to the communication design, especially routing. Thus, the routing requirements of FANETs surpass those of MANETs or VANETs. In this paper, we present UAV classification, communication and application architectures, and an exhaustive survey of the existing routing protocols for flying ad hoc networks. Furthermore, we highlight the key features, strengths and weaknesses, and different mobility models used for the performance evaluation of the existing FANET routing protocols. More importantly, a proposed taxonomy and a review on the existing FANET routing protocols are presented. Finally, we highlight the existing challenges and open research issues.
Synthesis of Renin Inhibitors Containing a Sulfonemethylene Isostere at Their N-Terminals (1990)

Abstract We describe an efficient synthesis of highly active renin inhibitors containing a sulfonemethylene isostere at their N-terminals and a hydroxyethylene isostere at their C-terminals. The stereospecific synthesis of N-terminal key intermediate, L-N-[(2R)-2-benzyl(or 1-naphthylmethyl)-3-hydroxypropionyl]norleucine t-butyl ester is described.
Revisiting microbe-metabolite interactions: doing better than random (2019)

I. ABSTRACT Recently, Quinn and Erb et al [1] made the case that when used correctly, correlation and proportionality can outperform MMvec when identifying microbe-metabolite interactions. We revisit this comparison and show that the proposed correlation and proportionality are outperformed by MMvec on real data due to their inability to deal with sparsity commonly observed in microbiome and metabolome datasets.
Development of a custom-designed echo particle image velocimetry system for multi-component hemodynamic measurements: system characterization and initial experimental results (2008)

We have recently developed an ultrasound-based velocimetry technique, termed echo particle image velocimetry (Echo PIV), to measure multi-component velocity vectors and local shear rates in arteries and opaque fluid flows by identifying and tracking flow tracers (ultrasound contrast microbubbles) within these flow fields. The original system was implemented on images obtained from a commercial echocardiography scanner. Although promising, this system was limited in spatial resolution and measurable velocity range. In this work, we propose standard rules for characterizing Echo PIV performance and report on a custom-designed Echo PIV system with increased spatial resolution and measurable velocity range. Then we employed this system for initial measurements on tube flows, rotating flows and in vitro carotid artery and abdominal aortic aneurysm (AAA) models to acquire the local velocity and shear rate distributions in these flow fields. The experimental results verified the accuracy of this technique and indicated the promise of the custom Echo PIV system in capturing complex flow fields non-invasively.
A MEM varactor tuned-voltage controlled oscillator fabricated using 0.35&#x03BC;m SiGe BiCMOS technology (2007)

In this paper, design and realization of a parallel plate dual gap MEM-Varactor based -G <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">m</sub> LC voltage controlled oscillator (VCO) is presented. The VCO is implemented with AMS 0.35 mum-SiGe BiCMOS process that includes high-speed SiGe Heterojunction Bipolar Transistors (HBTs). MEM- Varactor is fabricated in Sabanci University's cleanroom and includes six layers and five mask steps. MEM-Varactor and VCO is integrated on a FR4 substrate using wire bonder. With the actuation voltage of 0 to 10V, 70 MHz tuning range is measured from MEM-Varactor integrated VCO that is in the range 7.72 GHz to 7.80 GHz. Fundamental frequency output power changes between -2 dBm and 0 dBm, without the losses depending on the tuning voltage.
The structure of human olfactory space (2009)

We analyze the psychophysical responses of human observers to an ensemble of monomolecular odorants. Each odorant is characterized by a set of 146 perceptual descriptors obtained from a database of odor character profiles. Each odorant is therefore represented by a point in highly multidimensional sensory space. In this work we study the arrangement of odorants in this perceptual space. We argue that odorants densely sample a two-dimensional curved surface embedded in the multidimensional sensory space. This surface can account for more than half of the variance of the psychophysical data. We also show that only 12 percent of experimental variance cannot be explained by curved surfaces of substantially small dimensionality (&lt;10). We suggest that these curved manifolds represent the relevant spaces sampled by the human olfactory system, thereby providing surrogates for olfactory sensory space. For the case of 2D approximation, we relate the two parameters on the curved surface to the physico-chemical parameters of odorant molecules. We show that one of the dimensions is related to eigenvalues of the molecule connectivity matrix, while the other is correlated with measures of the molecule polarity. We discuss the behavioral significance of these findings.
Using the Preparation Phase of the Multiphase Optimization Strategy to Develop a Messaging Component for Weight Loss: Formative and Pilot Research (Preprint) (2019)

<sec> <title>BACKGROUND</title> Mobile messaging is often used in behavioral weight loss interventions, yet little is known as to the extent to which they contribute to weight loss when part of a multicomponent treatment package. The multiphase optimization strategy (MOST) is a framework that researchers can use to systematically investigate interventions that achieve desirable outcomes given specified constraints. </sec> <sec> <title>OBJECTIVE</title> This study describes the use of MOST to develop a messaging intervention as a component to test as part of a weight loss treatment package in a subsequent optimization trial. </sec> <sec> <title>METHODS</title> On the basis of our conceptual model, a text message intervention was created to support self-regulation of weight-related behaviors. We tested the messages in the ENLIGHTEN feasibility pilot study. Adults with overweight and obesity were recruited to participate in an 8-week weight loss program. Participants received a commercially available self-monitoring smartphone app, coaching calls, and text messages. The number and frequency of text messages sent were determined by individual preferences, and weight was assessed at 8 weeks. </sec> <sec> <title>RESULTS</title> Participants (n=9) in the feasibility pilot study lost 3.2% of their initial body weight over the 8-week intervention and preferred to receive 1.8 texts per day for 4.3 days per week. Researcher burden in manually sending messages was high, and the cost of receiving text messages was a concern. Therefore, a fully automated push notification system was developed to facilitate sending tailored daily messages to participants to support weight loss. </sec> <sec> <title>CONCLUSIONS</title> Following the completion of specifying the conceptual model and the feasibility pilot study, the message intervention went through a final iteration. Theory and feasibility pilot study results during the preparation phase informed critical decisions about automation, frequency, triggers, and content before inclusion as a treatment component in a factorial optimization trial. </sec> <sec> <title>CLINICALTRIAL</title> ClinicalTrials.gov NCT01814072; https://clinicaltrials.gov/ct2/show/NCT01814072 </sec>
Structure‐property behavior of films containing disk spherulites: A model study (1982)

Abstract Thin films of a polyester of lactic and glycolic acid were prepared to give controlled amounts of disk spherulites. The spherulite contents ranged from zero to 100% and were accurately measured. The stress‐strain properties of the films were then determined at 60°C, i.e., about 20°C above the glass transition temperature T g . The mechanical behavior varied quite systematically with spherulite content and displayed little dependence on spherulite size. It was found that much of the mechanical data could be reasonably well described by a simple composite model. In addition, the yield strain as well as the strain to break could be principally coupled to the deformation of only the amorphous phase. SEM and optical microscopy studies supported the above conclusion, also demonstrating that the isolated spherulites adhered well to the amorphous matrix and behaved as stress concentrators in the system when the deformation temperature was above T g .
Engineering secondary cell wall deposition in plants (2012)

Summary Lignocellulosic biomass was used for thousands of years as animal feed and is now considered a great sugar source for biofuels production. It is composed mostly of secondary cell walls built with polysaccharide polymers that are embedded in lignin to reinforce the cell wall structure and maintain its integrity. Lignin is the primary material responsible for biomass recalcitrance to enzymatic hydrolysis. During plant development, deep reductions of lignin cause growth defects and often correlate with the loss of vessel integrity that adversely affects water and nutrient transport in plants. The work presented here describes a new approach to decrease lignin content while preventing vessel collapse and introduces a new strategy to boost transcription factor expression in native tissues. We used synthetic biology tools in A rabidopsis to rewire the secondary cell network by changing promoter‐coding sequence associations. The result was a reduction in lignin and an increase in polysaccharide depositions in fibre cells. The promoter of a key lignin gene, C 4 H , was replaced by the vessel‐specific promoter of transcription factor VND 6 . This rewired lignin biosynthesis specifically for vessel formation while disconnecting C4H expression from the fibre regulatory network. Secondly, the promoter of the IRX 8 gene, secondary cell wall glycosyltransferase, was used to express a new copy of the fibre transcription factor NST 1 , and as the IRX 8 promoter is induced by NST 1 , this also created an artificial positive feedback loop ( APFL ). The combination of strategies—lignin rewiring with APFL insertion—enhances polysaccharide deposition in stems without over‐lignifying them, resulting in higher sugar yields after enzymatic hydrolysis.
Cloud-Based Automated Design and Additive Manufacturing: A Usage Data-Enabled Paradigm Shift (2015)

Integration of sensors into various kinds of products and machines provides access to in-depth usage information as basis for product optimization. Presently, this large potential for more user-friendly and efficient products is not being realized because (a) sensor integration and thus usage information is not available on a large scale and (b) product optimization requires considerable efforts in terms of manpower and adaptation of production equipment. However, with the advent of cloud-based services and highly flexible additive manufacturing techniques, these obstacles are currently crumbling away at rapid pace. The present study explores the state of the art in gathering and evaluating product usage and life cycle data, additive manufacturing and sensor integration, automated design and cloud-based services in manufacturing. By joining and extrapolating development trends in these areas, it delimits the foundations of a manufacturing concept that will allow continuous and economically viable product optimization on a general, user group or individual user level. This projection is checked against three different application scenarios, each of which stresses different aspects of the underlying holistic concept. The following discussion identifies critical issues and research needs by adopting the relevant stakeholder perspectives.
Binding of feline immunodeficency viral gag-p24 polypepdide to non immune Igs (1988)

Available data on the existence of lentivirus proteins with properties of unconventional Ag for B cells, have been so far restricted to human immunodeficiency virus (i.e. gp-120 of HIV-I). By using biotinylated-MAbs-anti-biotin IgG as readout system, we now report that gag-p24 antigen, either assembled in feline immunodeficiency virus (FIV) particles or expressed as recombinant polypeptide (rec.p24) may bind to nonimmune IgGs purified from mouse or cat sera. Moreover, FACS scanning experiments are consistent with the possibility that rec.p24 interacts with surface-Ig in a sub-population (5-6%) of rodent B cells. We hypothesize that gag-p24 peptide encoded regions may bind to unconventional Ig sites or, alternatively, that they may represent 'public' epitopes for natural polyreactive antibody.
Characterization of unstable pEntYN10 from enterotoxigenicEscherichia coli(ETEC) O169:H41 (2015)

Enterotoxigenic Escherichia coli (ETEC) serotype O169:H41 has been an extremely destructive epidemic ETEC type worldwide. The strain harbors a large unstable plasmid that is regarded as responsible for its virulence, although its etiology has remained unknown. To examine its genetic background specifically on the unstable retention and responsibility in the unique adherence to epithelial cells and enterotoxin production, the complete sequence of a plasmid, pEntYN10, purified from the serotype strain was determined. The length is 145,082 bp; its GC content is 46.15%. It contains 182 CDSs, which include 3 colonization factors (CFs), an enterotoxin, and large number of insertion sequences. The repertory of plasmid stability genes was extraordinarily scant. Uniquely, results showed that 3 CFs, CS6, CS8 (CFA/III)-like, and K88 (F4)-like were encoded redundantly in the plasmid with unique variations among previously known subtypes. These three CFs preserved their respective gene structures similarly to those of other ETEC strains reported previously with unique sequence variations respectively. It is particularly interesting that the K88-like gene cluster of pEntYN10 had 2 paralogous copies of faeG, which encodes the major component of fimbrial structure. It remains to be verified how the unique variations found in the CFs respectively affect the affinity to infected cells, host range, and virulence of the ETEC strain.
A high-performance liquid chromatographic method for determination of the niguldipine analogue DHP-014 (2005)

A simple and reliable reversed-phase high-performance liquid chromatography method was developed and validated for the determination of DHP-014, a niguldipine analogue with potent P-glycoprotein inhibitory and negligible calcium channel blocking properties, in rat plasma. DHP-014 and niguldipine hydrochloride (the internal standard) were extracted from rat plasma by liquid extraction using hexane. DHP-014 was then separated by HPLC on a C18 column and quantified by ultraviolet detection at 238 nm. The mobile phase consisted of acetonitrile-aqueous 5 mM phosphate buffer (65:35, v/v) containing 0.4% (v/v) triethylamine adjusted to pH 7.0. The mean extraction efficiency of DHP-014 was 109.0 +/- 12.9, 97.7 +/- 8.0 and 102.9 +/- 7.5% for DHP-014 concentrations of 10, 50 and 100 nM, respectively (n = 5). The method was linear over the concentration range 2.5-200 nM with a regression coefficient of 0.998. The limit of detection of DHP-014 in rat plasma was 1.0 nM. The intra- and inter-day coefficients of variation for DHP-014 in rat plasma were 4.7-7.9 and 6.9-9.9%, respectively. The intra- and inter-day accuracy was 98.2-99.5 and 97.9-103%, respectively. The bioanalytical technique was used to determine DHP-014 in plasma samples in a pharmacokinetic study of DHP-014 administered to female Sprague-Dawley rats.
CT volume measurement for prognostic evaluation of unresectable hepatocellular carcinoma after TACE (2010)

AIM:To analyze the value of computed tomography(CT) volume measurements for evaluation of the survival rate of unresectable hepatocellular carcinoma(HCC) patients after transcatheter arterial chemoembolization(TACE).METHODS:One hundred and sixty-six unresectable HCC patients after TACE were involved in this retrospective study.Hepatic CT scan was performed for all patients before and 4 wk to 2 mo after TACE to def ine the morphologic features of HCC including its largest diameter,volume,product of the great...
Sciatic Nerve Catheter Placement: Success with Using the Raj Approach (2009)

Use of a simple landmark between easily identifiable bony structures enhances the simplicity and placement of a sciatic nerve catheter and is recommended for use in clinical practice.
Improvement of ageing simulation of electronic circuits based on behavioural modelling (2005)

In this paper, we will demonstrate how to improve the ageing simulation by the use of a behavioural modelling language like VHDL-AMS, in order to efficiently simulate the reliability of integrated circuit in their electrical context.
A comprehensive preclinical assessment of late-term imaging markers of radiation-induced brain injury (2019)

These results demonstrate that CRT leads to late-term morphological changes, reorganization of neural connections, and metabolic dysfunction. The correlation between imaging markers and cognitive deficits can be used to assess late-term side effects of brain tumor treatment and evaluate efficacy of new interventions.
Novel contact lens electrode array for multi-electrode electroretinography (meERG) (2011)

The multi-electrode electroretinogram (meERG) is a novel tool that may find application in early detection of retinal degenerative disease. A 33-channel contact lens electrode array has been prototyped, characterized, and tested on a human subject. The meERG was recorded with SNR well above minimum requirements for clinical electroretinography.
Analysis of the x-ray photoelectron spectrum of Teflon AF 1600 (1997)

The C 1s, F 1s, and O 1s components of the x-ray photoelectron spectroscopy spectrum of Teflon AF 1600 have been obtained, and their constituent peaks were separated and attributed. The effect of an intervening carbon atom on the F 1s spectrum has been shown to decrease the inductive effect of a next-nearest neighbor fragment. An unexpected chemical shift in the O 1s spectrum has been traced to nonbonded steric interactions of close lying rings.