gebhart/patrepeval huggingface dataset:
Diagnostic of power transformers in Sri Lanka application of dielectric spectroscopy in frequency domain (2002)

Selected results of a project, which aim at building up knowledge on diagnostics of power transformers at Ceylon Electricity Board (CEB) of Sri Lanka, are presented. This is obtained by making dielectric frequency response (FDS) measurements on large number of selected transformers as well as on insulation models. The data gathered are analysed and a database is formed.
Abstract LB-378: Establishment of hepatic metastases in a steatotic microenvironment is enhanced by stromal derived MMP-12 (2010)

Abstract Non-alcoholic fatty liver disease (NAFLD), encompassing steatosis and progression to non-alcoholic steatohepatitis (NASH) are liver disorders of increasing clinical significance. We have shown that hepatic steatosis establishes a permissive microenvironment for metastatic seeding and tumor progression in the liver. We have identified MMP-12 (macrophage metalloelastase) as an important molecular component associated with hepatic steatosis and steatohepatitis. Wildtype mice in the C57Bl/6 background were fed a 42% fat diet for three months to induce hepatic steatosis. Affymetrix microarray analysis was performed on steatotic vs. normal murine livers to determine candidate genes altered between these liver microenvironments. Our results noted 715 significant changes in gene expression, of which matrix metalloproteinase 12 was among the most significantly up regulated genes in the steatotic microenvironment. Importantly, we have detected an upregulation of MMP-12 in human steatotic and steatohepatitis samples. MMP-12 deficient mice gained weight and developed diet-induced hepatic steatosis similar to wildtype mice. To determine whether MMP-12 affected metastasis, normal and steatotic MMP-12 deficient mice were tested with an experimental metastasis model via splenic injection of MC38 tumor cells. The number of resultant tumors per unit of tissue area in wildtype steatotic livers showed a 25 fold increase compared to tumors in MMP-12 deficient mice. Comparison of tumors between regular diet livers in wildtype and MMP12−/−mice was not significant. Immunohistochemical staining for F4/80 showed a reduction in the number of positive cells in MMP-12 deficient steatotic livers. Conclusions: Modulation of host factors is known to be important in tissue/site specific susceptibility to cancer metastases. MMP-12 can influence immune-mediated injury response by processing latent TNF alpha and regulating macrophage recruitment. Upregulation of matrix metalloproteinase 12 suggest a role for this protease in inflammatory mediated events in the distinct microenvironments of steatosis and steatohepatitis. The molecular mechanisms underlying the decreased establishment of metastatic tumors in MMP-12 deficient mice requires further investigation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-378.
Lokální modifikace povrchu plazmovou tužkou (2008)

Lokalni modifikace povrchu plazmovou tužkou, testovani
povrchove energie po upravě plazmatem.
Supplementary Figure 2 from Malignant B Cells Skew the Balance of Regulatory T Cells and T<sub>H</sub>17 Cells in B-Cell Non-Hodgkin's Lymphoma (2023)

Supplementary Figure 2 from Malignant B Cells Skew the Balance of Regulatory T Cells and T&lt;sub&gt;H&lt;/sub&gt;17 Cells in B-Cell Non-Hodgkin's Lymphoma
100 Watt Super Audio Amplifier Using New Mos Devices (1977)

A 100 watt audio amplifier was recently developed using a new Power MOSFET which was developed by our MOS Device Group. The Power MOSFET has several advantages over bipolar transistors. It has good frequency response, no carrier storage delay, thermal stability, no secondary breakdown and high input impedance.
Ground motion simulations relating topographic amplification and landslide initiation during the Mw7.6 2005 Kashmir Earthquake. (2022)

&amp;lt;p&amp;gt;The 2005 Mw 7.6 Kashmir earthquake is the most devastating earthquake to occur along the Himalayan arc, resulting in 87,000 fatalities, 69,000 injuries, and 2.8 million people left homeless. The rupture occurred on a 30&amp;amp;#176; NE dipping thrust fault and generated a ~70 km long surface rupture that concentrated much of the damage. Along with the primary hazard caused by the seismic shaking, many secondary hazards, including nearly 3,000 coseismic landslides, were initiated due to the shaking from this event. In the absence of seismic data recorded near the source of this earthquake, we attempt to understand the relationships between ground shaking and coseismic landslides by using numerical techniques to model the ground motions and topographic amplification from the Kashmir earthquake. We use the spectral element method implemented in SPECFEM3D to model kinematic rupture scenarios for the Kashmir earthquake in both high resolution and flat topography, obtaining a topographic amplification factor by comparing these simulations. We generate a range of seismic source models using the rupture generator FakeQuakes, starting with a mean slip model from the earthquake and adding stochastic variations to both static and kinematic rupture properties to produce variable rupture scenarios. The advantages of this technique, compared to calculating ground motions from one finite fault model, is that by adding stochastic variations, the source model has higher, more realistic, frequencies, and that it enables the investigation of how varying rupture properties affect topographic amplification. We calculate both peak ground velocity (PGV) and topographic amplification for each scenario and compare the average and standard deviations to locations of landslide initiation. Preliminary results from five earthquake sources shows that with changing source parameters, PGV and topographic amplification patterns remain relatively constant and that positive amplifications are concentrated at the peaks of ridges and negative amplifications are concentrated in valleys. There are no obvious relationships between the patterns of amplification and landsliding, possibly due to limitations in landslide mapping. Other causes of landslides--such as variations in lithology, distance to anthropogenic features (roads, construction), distance to faults, and distance to ridges, and rivers--will be investigated further to understand the relationships between topographic amplification and other triggers. Future work includes combining these results with similar studies for earthquakes with different source properties and in different topographic settings to further understand the controlling factors of topographic amplification as a trigger for coseismic landslides.&amp;lt;/p&amp;gt;
Inductive power transfer with wireless communication system for electric vehicles (2013)

This paper explores the employment of inductive power transfer and data transfer (IPDT) for charging of electric vehicles (EV). The main objective of this paper spans the analysis and development of the inductive power transfer (IPT) design, and the practical implementation of the system prototype. The IPT typically consists of two parts; the transmitter and the receiver part. The recitified DC at the transimitter is converted to AC of high frequency through a DC-AC converter with resonat circuits at both ends (receiever and transmitter). The power transferred to the secondary is used for electric vehicle battery charging through a rectified. Data also is transferred wirelessly in order to control the electric vehicles charging process throughout different proposed scenarios. A prototype has been tested experimentally for the IPDT.
Liquid-Cooled Heat Sink Optimization for Thermal Imbalance Mitigation in Wide-Bandgap Power Modules (2020)

Abstract Power semiconductor die layout in substrates used in power modules is generally optimized for minimum electrical parasitics (e.g., stray inductance) by considering the minimum spacing between dies for thermal decoupling. The layout assumes sufficient heat spreading and transfer from dies to the cooling structure. For module designs using a direct substrate cooling method, the base plate is removed, leading to a steady-state thermal asymmetry in the power module due to insufficient heat spreading/transfer. This causes significant temperature differences among the devices. Such unintentional thermal asymmetries can lead to undesirable asymmetries in power conversion among semiconductor devices, which impact reliability. This article proposes a thermal imbalance mitigation method that uses evolutionary optimized liquid-cooled heat sinks to improve the thermal loading among devices.
New method for increasing matching accuracy and reducing process time of fingerprint data by the fractional Fourier transform (2010)

In the light of a limited number of related studies, a new data processing method for increasing matching accuracy and reducing process time in fingerprint authentication using the fractional Fourier transform (FRT) was proposed being also taken into account protection of personal information. The new method was based on the minimization of error rate (MER) obtained from the false acceptance rate (FAR) and the false rejection rate (FRR). It was highlighted that making use of analyses on the peak value of the normalized cross-correlation function of the FRT intensity distributions was the key. By changing the extraction range and the order of FRT in each of the scanned lines of fingerprint images, feasibility was investigated. As a result, it was clarified that the data processed by the FRT provided higher matching accuracy than those processed by the conventional Fourier transform (FT). In addition, it was found that the matching accuracy was not strongly dependent on the data size extracted from original fingerprint images. This fact led to reduction of the matching time.
Discharge coefficients for ogee weirs including the effects of a sloping upstream face (2020)

Abstract Discharge coefficients (C0) for ogee weirs are essential factors for predicting the discharge-head relationship. The present study investigates three influences on the C0: effect of approach depth, weir upstream face slope, and the actual head, which may differ from the design head. This study uses experimental data with multiple non-linear regression techniques and Gene Expression Programming (GEP) models that are applied to introduce practical equations that can be used for design. Results show that the GEP method is superior to the regression analysis for predicting the discharge coefficient. Performance criteria for GEP are R2 = 0.995, RMSE = 0.021 and MAE = 0.015. Design examples are presented that show that the proposed GEP equation correlates well with the data and eliminates linear interpolation using existing graphs.
Simulink based Model Realization for CDMA Communication over Power Lines (2005)

This paper discusses a Simulink based model realization for many-to-one and one-to-many access CDMA communication over power lines through a 2-wire power line cord with neutral line cord (2WN). In addition, a hardware prototype with TCP/IP data link layer (IEEE802.3) that can send and receive video images at a speed of 1 Mbps through 2WN is introduced.
Biomass, nutrient accumulation and tree size relationships for drip- and microsprinkler-irrigated orange trees (2015)

A three-year study was conducted at two sites in Florida with Spodosols and Entisols differing in drainage characteristics to: 1) estimate biomass and nutrient accumulation in 1- to 5-year-old citrus and their relationship to tree size; and 2) determine tree size characteristics as a function of time. Nitrogen (N) accumulation with intensive drip- and microsprinkler fertigation increased by 45% over conventional grower practice (Conventional) at the Spodosol site (SS). Phosphorus (P) and potassium (K) accumulation were similar. The results further showed that intensive fertigation increased citrus growth rate (by up to 330%) in 6 months resulting in greater canopy volumes and trunk cross-sectional areas than conventional practices at the Entisol site. Results at SS showed that canopy size and trunk cross-sectional areas for Conventional were similar to drip fertigation probably because it was fertigated. This suggests the possibility of improving nutrient accumulation and tree size with intensive fertigation practices and a modified, fertigated conventional practice.
ETUDE DE LA DEACETYLASE HDAC6 : UNE ENZYME MULTIFONCTIONNELLE (2005)

HDAC6 is a multifunctional enzyme with two tandem catalytic domains and an ubiquitin binding domain. Mainly cytoplasmic, HDAC6 is associated with microtubules, and deacetylates tubulin on lysine 40. Furthermore, cellular management of misfolded proteins and aggresomes is modulated by HDAC6 action. This protein also regulates the acetylation of various proteins, like histones or HSP90, and is involved in several cellular processes. First of all, my work describes additional functions of HDAC6 in stress response. I show that HDAC6 controls HSPs genes activation and the cellular recovery process within the context of cellular stress response. Then the discovery of SE14 domain in the human HDAC6 is an original aspect of this study. This domain is a key element in the human HDAC6 retention in the cytoplasm. Moreover in vitro and in vivo experiences have shown that integrity of both deacetylation domains is required for HDAC6 activity. Finally, this work shows that HDAC6 is involved in osteoclast differentiation. Indeed HDAC6 interacts with mDIA2 and is probably involved in the rearrangement of the cytosqueletton during osteoclast maturation.
N-(4-hydroxyphenyl)retinamide: a Potent Inducer of Apoptosis in Human Neuroblastoma Cells (1994)

Journal Article N -(4-hydroxyphenyl)retinamide: a Potent Inducer of Apoptosis in Human Neuroblastoma Cells Get access Agnese Mariotti, Agnese Mariotti *Affiliations of authors: Dipartimento di Genetica e Microbiologia, A. Buzzati Traverse, Universitàdi PaviaPavia, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar Edoardo Marcora, Edoardo Marcora *Affiliations of authors: Dipartimento di Genetica e Microbiologia, A. Buzzati Traverse, Universitàdi PaviaPavia, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar Giuseppe Bunone, Giuseppe Bunone *Affiliations of authors: Dipartimento di Genetica e Microbiologia, A. Buzzati Traverse, Universitàdi PaviaPavia, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar Alberto Costa, Alberto Costa European Institute of OncologyMilano, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar Umberto Veronesi, Umberto Veronesi Istituto Nazionale TumoriMilano Search for other works by this author on: Oxford Academic PubMed Google Scholar Marco A. Pierotti, Marco A. Pierotti Istituto Nazionale TumoriMilano Search for other works by this author on: Oxford Academic PubMed Google Scholar Giuliano Della Valle Giuliano Della Valle *Affiliations of authors: Dipartimento di Genetica e Microbiologia, A. Buzzati Traverse, Universitàdi PaviaPavia, Italy Correspondence to : Giuliano Della Valle, Dipartimento di Genetica e Microbiologia, A. Buzzati Traverso, Università di Pavia, Via Abbiategrasso 207, 27100 Pavia, Italy. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 16, 17 August 1994, Pages 1245–1247, https://doi.org/10.1093/jnci/86.16.1245 Published: 17 August 1994 Article history Received: 04 January 1994 Revision received: 21 April 1994 Accepted: 05 May 1994 Published: 17 August 1994
Role of CD38 in Airway Function (2006)

CD38, a 45-kDa cell surface glycoprotein, is involved in the synthesis of the calcium mobilizing second messenger molecule cyclic ADP-ribose. Cyclic ADP-ribose is known to release calcium from the sarcoplasmic reticulum of airway smooth muscle cells. The pharmacological features of cyclic ADP-ribose-mediated calcium release in airway smooth muscle cells are distinct from those mediated by inositol 1,4,5-trisphosphate and involve activation of ryanodine receptor channels. In airway smooth muscle cells, contractile agonists recruit cyclic ADP-ribose for intracellular calcium release in a receptor- and receptor-subtype-specific fashion. The CD38/cyclic ADP-ribose signaling has a role in airway function, since methacholine-induced airway resistance is significantly lower in CD38 deficient mice than in the wild type controls. The diminished airway responsiveness appears to result from lower intracellular calcium responses to spasmogens. In human airway smooth muscle cells, inflammatory and Th-2 cytokines increase the expression of CD38 and augment the capacity for cyclic ADP-ribose-mediated calcium release during agonist stimulation. These results suggest a role for cyclic ADP-ribose in airway smooth muscle hyperresponsiveness during inflammation. This review will focus on the role of CD38 and cyclic ADP-ribose in normal airway function and its potential contribution to airway hyperresponsiveness in inflammatory diseases such as asthma.
System Design of a Haptic Laparoscopic Telemanipulation System (2010)

In order to increase flexibility during laparoscopic surgery INKOMAN is introduced. This handheld telemanipulation is
operated like a common laparoscopic tool but provides additional flexibility at the instrument tip. In order to equip this
system with active haptic feedback requirements are derived from occurring forces during tissue manipulation, transparency
of the haptic system, mechanical soft tissue properties and human haptic capabilities. Based heron a novel piezoresistive 3-DOF force sensor has been developed. It is built on a multi-axial deformation body. Novel piezoresistive strain gauges have been developed to be integrated on the deformation body. The force sensor will measure contact forces between instrument and tissue. Based on those measurements an impedance controlled haptic interface will provide spatial haptic feedback to the surgeon. The device will be driven by brushless DC motors and transmits the haptic information via a parallel kinematic mechanism to the surgeon’s hand.
Efficient ∼4  µm emission from Pr3+/Yb3+ co-doped fluoroindate glass (2021)

<i>P</i><i>r</i><sup>3+</sup>/<i>Y</i><i>b</i><sup>3+</sup> co-doped fluoroindate (<i>I</i><i>n</i><i>F</i><sub>3</sub>) glasses were prepared by using a traditional melt-quenching method in dry <i>N</i><sub>2</sub> atmosphere. Pumped by a 976 or 1570 nm laser diode, efficient emissions at ∼4µ<i>m</i> were obtained from the <i>P</i><i>r</i><sup>3+</sup>/<i>Y</i><i>b</i><sup>3+</sup> co-doped glasses, which could be ascribed to the transition <sup>3</sup><i>F</i><sub>4</sub>→<sup>3</sup><i>H</i><sub>6</sub> of <i>P</i><i>r</i><sup>3+</sup> ions. The relative stimulated emission cross section was calculated to be ∼1.44×10<sup>-24</sup><i>m</i><sup>2</sup> at 4 µm, which was ∼4.2 times larger than that of transition <i>H</i><i>o</i><sup>3+</sup>:<sup>5</sup><i>I</i><sub>5</sub>→<sup>5</sup><i>I</i><sub>6</sub> (3.4×10<sup>-25</sup><i>m</i><sup>2</sup>). In addition, combined with transitions <sup>1</sup><i>G</i><sub>4</sub>→<sup>3</sup><i>F</i><sub>3</sub> and <sup>1</sup><i>G</i><sub>4</sub>→<sup>3</sup><i>F</i><sub>4</sub> of <i>P</i><i>r</i><sup>3+</sup> ions, ultra-broadband emission ranging from 2.7 to 4.2 µm was also obtained. Our results indicate that <i>P</i><i>r</i><sup>3+</sup>/<i>Y</i><i>b</i><sup>3+</sup>:<i>I</i><i>n</i><i>F</i><sub>3</sub> glasses could be used to develop efficient ∼4µ<i>m</i> lasers and widely tunable mid-infrared lasers.
Portable low THz imaging radars for automotive applications (2015)

Compact frequency extenders enable the current generation of portable network analysers to be used in the low THz bands of 150-300 GHz. The wide instantaneous bandwidth of these extenders support complex waveforms within systems intended for automotive radars and communication networks. Recent experimental results of such radars intended for atmospheric measurements and autonomous vehicle applications are described.
Assembly and Disassembly of the Capsid-Like External Scaffold of Immature Virions during Vaccinia Virus Morphogenesis (2009)

Infectious poxvirus particles are unusual in that they are brick shaped and lack symmetry. Nevertheless, an external honeycomb lattice comprised of a capsid-like protein dictates the spherical shape and size of immature poxvirus particles. In the case of vaccinia virus, trimers of 63-kDa D13 polypeptides form the building blocks of the lattice. In the present study, we addressed two questions: how D13, which has no transmembrane domain, associates with the immature virion (IV) membrane to form the lattice structure and how this scaffold is removed during the subsequent stage of morphogenesis. Interaction of D13 with the A17 membrane protein was demonstrated by immunoaffinity purification and Western blot analysis. In addition, the results of immunogold electron microscopy indicated a close association of A17 and D13 in crescents, as well as in vesicular structures when crescent formation was prevented. Further studies indicated that binding of A17 to D13 was abrogated by truncation of the N-terminal segment of A17. The N-terminal region of A17 was also required for the formation of crescent and IV structures. Disassembly of the D13 scaffold correlated with the processing of A17 by the I7 protease. When I7 expression was repressed, D13 was retained on aberrant virus particles. Furthermore, the morphogenesis of IVs to mature virions was blocked by mutation of the N-terminal but not the C-terminal cleavage site on A17. Taken together, these data indicate that A17 and D13 interactions regulate the assembly and disassembly of the IV scaffold.
Whole genome analysis reveals the genomic complexity in metastatic cutaneous squamous cell carcinoma (2022)

ABSTRACT Metastatic cutaneous squamous cell carcinoma (cSCC) is a highly morbid disease requiring radical surgery and adjuvant therapy that is associated with reduced overall survival. Yet compared to other advanced malignancies, relatively little is known of the genomic landscape of metastatic cSCC. We have previously reported the mutational signatures and mutational patterns of CCCTC-binding factor (CTCF) regions in metastatic cSCC. However, many other genomic components (indel signatures, non-coding drivers, and structural variants) of metastatic cSCC have not been reported. To this end, we performed whole genome sequencing on lymph node metastases and blood DNA from 25 cSCC patients with regional metastases of the head and neck. We designed a multifaceted computational analysis at the whole genome level to provide a more comprehensive perspective of the genomic landscape of metastatic cSCC. In the noncoding genome, 3’UTR regions of EVC (48% of specimens), PPP1R1A (48% of specimens) and ABCA4 (20% of specimens) along with the tumor-suppressing lncRNA LINC01003 (64% of specimens) were significantly functionally altered (Q-value &lt; 0.05) and represent potential noncoding biomarkers of cSCC. Recurrent copy number loss in the tumor suppressor gene PTPRD was observed. Gene amplification was much less frequent and few genes were recurrently amplified. Single nucleotide variants driver analyses from 3 tools confirmed TP53 and CDKN2A as recurrently mutated genes but also identified C9 as potential novel driver in this disease. Further, indel signature analysis highlighted the dominance of ID signature 13 (ID13) followed by ID8 and ID9. ID 9 has previously been shown to have no association with skin melanoma, unlike ID 13 and 8, suggesting a novel pattern of indel variation in metastatic cSCC. The enrichment analysis of various genetically altered candidates shows enrichment of ‘TGF-beta regulation of extracellular matrix’ and ‘Cell cycle G1 to S check points’. These enriched terms are associated with genetic instability, cell proliferation, and migration providing mechanisms of genomic drivers of metastatic cSCC.