gebhart/patrepeval huggingface dataset:
Topical Prostaglandins for Galucoma Therapy (1997)

Wyse, Tamara B. M.D.; Talluto, Donna M. M.D.; Rosenberg, Lisa F. M.D.; Ruderman, Jon M. M.d. Author Information
Spontaneous Motor Rhythms of the Back and Legs in a Patient With a Complete Spinal Cord Transection (2009)

The rhythmic activity observed in the patient appeared related to the activation of a spinal pattern generator akin to what has been described in most animal species after complete spinal lesions.
Numerical Software Quality Control in Object Oriented Development (2005)

This paper proposes new method to predict the number of the remaining bugs at the delivery inspection applied to every iteration of OOD, object oriented development. Our method consists of two parts. The first one estimates the number of the remaining bugs by applying the Gompertz curve. The second one uses the interval estimation called OOQP, object oriented quality probe. The basic idea of OOQP is to randomly extract a relatively small number of test cases, usually 10 to 20% of the entire test cases, and to execute them in the actual operation environment. From the test result of OOQP, we can efficiently predict the number of the remaining bugs by the interval estimation. The premier problem of OOQP is that OOD is imposed to use the system design specification document whose contents, like UML, tend to be ambiguous. Our estimation method works well at a matrix-typed organization where a QA team and a development team collaboratively work together to improve the software quality.
Charge trapping analysis of Al2O3 films deposited by atomic layer deposition using H2O or O3 as oxidant (2012)

In this work, the authors focus on the charge trapping behavior of Al2O3 layers deposited by atomic layer deposition. The goal is to give an insight into the effects of the oxidant source (H2O or O3) and the postdeposition anneal on the charging phenomena and the generation of new defects during electrical stress. For this purpose, current–voltage, capacitance–voltage, and conductance–voltage characteristics of Al/Al2O3/p-Si capacitors are analyzed before and after constant voltage stress and several phenomena such as the generation of neutral traps in the bulk dielectric, slow states, interface states, and charge trapping related degradation during the electrical stress are investigated. Finally, the impact of the oxidant source on the Al2O3 layer reliability is discussed.
Frictional Melting in Hydrothermal Fluid‐Rich Faults: Field and Experimental Evidence From the Bolfín Fault Zone (Chile) (2021)

Tectonic pseudotachylytes are thought to be unique to certain water-deficient seismogenic environments and their presence is considered to be rare in the geological record. Here, we present field and experimental evidence that frictional melting can occur in hydrothermal fluid-rich faults hosted in the continental crust. Pseudotachylytes were found in the >40 km-long Bolfín Fault Zone of the Atacama Fault System, within two ca. 1 m-thick (ultra)cataclastic strands hosted in a damage-zone made of chlorite-epidote-rich hydrothermally altered tonalite. This alteration state indicates that hydrothermal fluids were active during the fault development. Pseudotachylytes, characterized by presenting amygdales, cut and are cut by chlorite-, epidote- and calcite-bearing veins. In turn, crosscutting relationship with the hydrothermal veins indicates pseudotachylytes were formed during this period of fluid activity. Rotary shear experiments conducted on bare surfaces of hydrothermally altered rocks at seismic slip velocities (3 m s<sup>-1</sup>) resulted in the production of vesiculated pseudotachylytes both at dry and water-pressurized conditions, with melt lubrication as the primary mechanism for fault dynamic weakening. The presented evidence challenges the common hypothesis that pseudotachylytes are limited to fluid-deficient environments, and gives insights into the ancient seismic activity of the system. Both field observations and experimental evidence, indicate that pseudotachylytes may easily be produced in hydrothermal environments, and could be a common co-seismic fault product. Consequently, melt lubrication could be considered one of the most efficient seismic dynamic weakening mechanisms in crystalline basement rocks of the continental crust.
Motion control with induction motors (1994)

Induction motors (IM) provide a very wide speed range, mechanically robust and relatively low cost motion control option. An up-to-date summary of the status of induction motor motion control technology is the subject of this paper. The topics which this paper includes are as follows: basic motion control system requirements; field orientation instantaneous torque control principles for induction motors (FO-IM); current regulators for induction motor motion control; flux and torque regulators for induction motor motion control; self commissioning and continuous self-tuning for field orientation. Technology advances based on modern control and estimation theory have the potential to further enhance the capability of this important class of servo drive systems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Modificación de propiedades funcionales de proteínas procedentes de subproductos de la industria pesquera vía reacción de Maillard (2011)

En los ultimos anos, la recuperacion de los residuos de la industria alimentaria ha suscitado un gran interes. El concepto de residuo esta comenzando a cambiar hacia una idea de materia prima disponible. Una utilizacion eficaz de esta materia permitiria la recuperacion de ingredientes, como las proteinas, con las caracteristicas optimas para su consumo en alimentacion humana. En este trabajo se hace una breve introduccion de los metodos mas comunes de recuperacion de proteinas, y se presenta la reaccion de Maillard, tambien conocida como glicacion, como un metodo alternativo de recuperacion. Para estudiar en detalle los cambios conformacionales producidos en una proteina a causa de la reaccion de Maillard, y poder establecer una relacion con sus cambios en funcionalidad de tipo tecnologico (propiedades espumantes, propiedades emulsionantes y solubilidad), se eligio una proteina modelo para ser sometida a glicacion, concretamente, la ?- lactoalbumina, que constituye una de las proteinas principales de un residuo lacteo como es el lactosuero. Asimismo se eligio como fuente principal de residuo, aquellos generados por la industria pesquera, en concreto, subproductos del procesado de bonito del norte fresco y subproductos de la industria conservera del atun. En ambos casos, se aplicaron una serie de metodos de extraccion para trabajar, en el caso del producto fresco, con fracciones de proteinas sarcoplasmicas y miofibrilares, y en el caso del subproducto procedente de industria conservera, con concentrados proteicos. Tras la recuperacion, las proteinas fueron identificadas mediante tecnicas proteomicas. A continuacion, se efectuo el proceso de glicacion empleando carbohidratos de diferente tamano molecular y, por tanto, con diferente reactividad. De nuevo, sus cambios conformacionales fueron relacionados con sus nuevas propiedades funcionales que en algunos casos resultaron mejoradas, principalmente en el caso de la solubilidad. La optimizacion del proceso de glicacion abre una puerta interesante para la utilizacion de estos residuos como nueva fuente generadora de ingredientes funcionales.
Effects of Lipoxygenase Inhibitors on the Arachidonic Acid Cascade in the Rabbit Cornea After Injury (1988)

A cryogenic lesion in the rabbit cornea that promotes the formation of arachidonic acid metabolites was used as a model to test the action of two new lipoxygenase inhibitors, TEI-8005 and TEI-8006. The action of these two inhibitors was compared with that of CBS-113A, a new dual inhibitor of cyclooxygenase and lipoxygenase reactions, and with that of nordihydroguaiaretic acid (NDGA), a monooxygenase inhibitor and antioxidant. Injured corneas were incubated for 1 h at 36 degrees with 1-14C-arachidonic acid. Inhibitors at concentrations of 1, 10 and 100 uM were added 10 minutes prior to the addition of arachidonic acid. TEI-8006 inhibited 5-hydroxyeicosatetraenoic acid (HETE) at 10 uM, and both 5- and 12-HETE at 100 uM. At 100 uM, CBS-113A also had the same effect, while TEI-8005 at 100 uM induced a more selective inhibition of 5-lipoxygenase. NDGA was the most potent inhibitor of lipoxygenase reactions, but was not selective. Prostaglandins were also affected differentially by the inhibitors. TEI-8006 and NDGA partially inhibited cyclooxygenase products at all concentrations, and CBS-113A produced inhibition at 10 and 100 uM. TEI-8005 did not affect the total cyclooxygenase products, but selectively inhibited thromboxane B2 and increased prostacyclin production at 100 uM. The effects of these inhibitors may be of value in understanding the mechanisms involved in corneal inflammation.
Supplementary Figure S6 from Targeting Small Cell Lung Cancer Harboring <i>PIK3CA</i> Mutation with a Selective Oral PI3K Inhibitor PF-4989216 (2023)

&lt;p&gt;PDF file 117K, Supplementary Figure S6: Profile of BIM isoforms in SCLC lines treated with a variety of cytotoxic agent&lt;/p&gt;
Quantitative Alterations of the Functionally Distinct Subsets of CD4 and CD8 T Lymphocytes in Asymptomatic HIV Infection (1997)

We determined the representation in asymptomatic human immunodeficiency virus (HIV) infection of the CD45RO+ and CD45RO- CD45RA+ subsets of CD4+ and CD8+ T lymphocytes, CD11b+ and CD11b- subsets of CD8+ T cells, and activated populations of these subsets. Three-color flow cytometry was used to quantitate the different CD4+ and CD8+ T cell populations in 116 asymptomatic HIV+ individuals. In asymptomatic HIV+ infection there was a significant relative increase in the CD4+ CD45RO+ and CD8+ CD45RO+ T cell subsets, which express CD38 and DR antigens, that correlated strongly with the decline in total CD4+ T cells. In addition, we found a loss of CD4+ CD45RO- and CD8+ CD45RO- T cells associated with progression of HIV infection (as measured by the decline in total CD4+ T cells). Studies presented here also indicate that, with the progression of asymptomatic HIV infection, CD8+ CD11b- T lymphocytes showed a significant decrease, whereas CD8+ CD11b+ T cells were significantly increased. This study demonstrates that the progression of HIV infection in asymptomatic patients involves the increase in CD45RO+ subsets of CD4+ and CD8+ T cells, the increase in CD8+ CD11b+ T cells, the decrease in CD45RO- CD45RA+ subsets of CD4 and CD8 T cells, and the decline in CD8+ CD11b- T cells.
Photochemistry at Interfaces (2015)

We have advanced our capabilities to investigate ultrafast excited state dynamics at a liquid interface using a pump to excite molecules to higher electronic states and then probe the subsequent time evolution of the interfacial molecules with femtosecond time delayed vibrational SFG.
Combining low-energy electron microscopy and scanning probe microscopy techniques for surface science: Development of a novel sample-holder (2014)

We introduce an experimental facility dedicated to surface science that combines Low-Energy Electron Microscopy/Photo-Electron Emission Microscopy (LEEM/PEEM) and variable-temperature Scanning Probe Microscopy techniques. A technical challenge has been to design a sample-holder that allows to exploit the complementary specifications of both microscopes and to preserve their optimal functionality. Experimental demonstration is reported by characterizing under ultrahigh vacuum with both techniques: Au(111) surface reconstruction and a two-layer thick graphene on 6H-SiC(0001). A set of macros to analyze LEEM/PEEM data extends the capabilities of the setup.
Effect of anti-β1 integrin antibody on lung seeding of osteosarcoma cells in live mice visualized by single-cell in vivo imaging. (2012)

10072 Background: Integrins play a role in tumor growth and metastasis (Int. J. Cancer 129, 2905-2915, 2011). However, the effect of integrin inhibition has not been visualized on single cancer cells in vivo. In this study, we used a powerful subcellular in vivo imaging model to demonstrate how an anti-integrin antibody affects seeding and growth of osteosarcoma cells on the lung. Methods: The 143B human osteosarcoma cell line expressing red fluorescent protein (RFP) in the cytoplasm and green fluorescent protein (GFP) in the nucleus was established. Using the double-labeled osteosarcoma cells, single cancer-cell seeding in the lung after i.v. injection of osteosarcoma cells was imaged in live mice. Results: The anti-b1 integrin monoclonal antibody, AIIB2, greatly inhibited the seeding of cancer cells on the lung while a control antibody had no effect. To image the efficacy of the anti-integrin antibody on spontaneous metastasis, mice with orthotopically-growing 143B-RFP cells in the tibia were also treated with AIIB2 or control anti-rat IgG1 antibody. After 3 weeks treatment, mice were sacrificed and primary tumors and lung metastases were evaluated with fluorescence imaging. AIIB2 significantly inhibited spontaneous lung metastasis but not primary tumor growth. In a separate experiment, the anti-β1 integrin antibody increased survival in the orthothopic osteosarcoma model. Conclusions: The efficacy of the anti-β1 integrin antibody against metastasis may be due to inhibition of lung seeding of the cancer cells. The increased survival of mice with orthotopically-growing 143B-RFP treated with AIIB2 may be due to inhibition of metastasis, which in turn may be inhibited by effect of the anti-β1 integrin on cancer-cell seeding in the lung.
Structure–Activity Relationship Refinement and Further Assessment of 4-Phenylquinazoline-2-carboxamide Translocator Protein Ligands as Antiproliferative Agents in Human Glioblastoma Tumors (2014)

Structure-activity relationships (SARs) within the 4-phenylquinazoline-2-carboxamide series of translocator protein (TSPO) ligands have been explored further by the synthesis and TSPO binding affinity evaluation of N-benzyl-N-ethyl/methyl derivatives variously decorated at the 6-, 2'-, 4'-, and 4″-positions. Most of the compounds showed high affinity with K(i) values in the nanomolar/subnanomolar range. A pharmacophore model was developed and employed to better address SAR data presented by the new TSPO ligands. A subset of the new compounds (5, 8, 12, and 19) were tested for their ability to inhibit the viability of human glioblastoma cell line U343. The observed antiproliferative effect was demonstrated to be specific for compound 19, endowed with the best combination of binding affinity and efficacy. Furthermore, the ability of 19 to induce mitochondrial membrane dissipation (Δψ(m)) substantiated the intracellular pro-apoptotic mechanism activated by the binding of this class of ligands to TSPO.
Naval Ocean Facilities Research And Development - An Historical Perspective And Current Status (1983)

The Navy's ocean facilities engineering research program was initiated at the Naval Civil Engineering Laboratory (NCEL) some 20 years ago and continues there as a vigorous component of the military ocean engineering program. This program exists to support the facilities and logistics needs and capabilities of naval operating forces. The scope of this research program ranges from fully developed ports and remote beach facilities to deep ocean construction sites in 20,000 feet of water. This program has led to hardware and methods suitable for direct application and benefit to operating forces and field activities. These accomplishments vary from a simple modification of a commercially available hand tool to permit a working diver to accomplish a new underwater task, to sophisticated finite element computer programs to analyze the motions and tensions of complex three-dimensional ocean cable structures, to an offshore bulk fuel handling system centering around a 62-ton single point mooring buoy secured by four drag embedded anchors, each having a holding capacity of over 400,000 pounds. As controlled by the overview nature of the paper, each topic is only briefly addressed. Although less than complete in technical detail, the paper serves as a thorough reference to naval ocean facilities R&D accomplishments.
양지꽃속(장미과)의 신종: 백두산양지꽃(Potentilla baekdusanensis M. Kim) (2018)

백두산에서 양지꽃속의 신종인 백두산양지꽃(Potentilla baekdusanensis M. Kim)을 새로이 발견하여 기재하였다. 백두산양지꽃은 잎이 우상복엽이며 엽신과 엽병에 털이 있고 3개의 상부 소엽이 하부 소엽보다 크며 포복경이 없어 양지꽃과 유사하다. 그러나 백두산양지꽃은 식물체가 소형이고 짧은 누운 털이 있으며 근생엽이 7장의 소엽으로 이루어졌고 하부 소엽이 작으며 소엽가장자리에 털이 없고 꽃잎 기부에 황적색의 무늬가 있다. 반면에, 양지꽃은 식물체가 대형이고 긴 곧은 털이 밀생하며 근생엽이 9-15장의 소엽으로 이루어졌고 하부 소엽이 크며 소엽가장자리에 긴털이 밀생하고 꽃잎 기부에 황적색의 무늬가 없는 점에서 두 종이 뚜렷하게 차이가 난다.
A Mechanistic Model to Predict the Cutting Force System for Arbitrary Drill Point Geometry (1998)

A mechanistic model is developed to predict the forces for arbitrary drill point geometry. The cutting lips are divided into elements and the elemental forces are determined from a fundamental oblique cutting model. A method is developed to parametrically define the cutting lip in three-dimensional space and to determine the oblique cutting parameters (cutting angles and chip thickness) at each element on the cutting lip. The model does not require calibration experiments for each point geometry. The conical drill is used to determine the model coefficients for a tool and workpiece material combination and these are used for other drill point geometry. Model simulations match experimental data very well for four commercial drill point geometry—the Racon, Helical, Bickford and Double angle drill points.
A state variable for crumpled thin sheets (2018)

Despite the apparent ease with which a sheet of paper is crumpled and tossed away, crumpling dynamics are often considered a paradigm of complexity. This complexity arises from the infinite number of configurations a disordered crumpled sheet can take. Here we experimentally show that key aspects of crumpling have a very simple description; the evolution of the damage in crumpling dynamics can largely be described by a single global quantity, the total length of all creases. We follow the evolution of the damage network in repetitively crumpled elastoplastic sheets, and show that the dynamics of this quantity are deterministic, and depend only on the instantaneous state of the crease network and not at all on the crumpling history. We also show that this global quantity captures the crumpling dynamics of a sheet crumpled for the first time. This leads to a remarkable reduction in complexity, allowing a description of a highly disordered system by a single state parameter. Similar strategies may also be useful in analyzing other systems that evolve under geometric and mechanical constraints, from faulting of tectonic plates to the evolution of proteins.
Comparative Proteomic Profiling of Human Bile Reveals SSP411 as a Novel Biomarker of Cholangiocarcinoma (2012)

We successfully constructed a proteomic profile of CC bile proteins, providing a valuable pool novel of candidate biomarkers. SSP411 has potential as a biomarker for the diagnosis of CC.
Role of the arginine deiminase system in protecting oral bacteria and an enzymatic basis for acid tolerance (1988)

The arginine deiminase system was found to function in protecting bacterial cells against the damaging effects of acid environments. For example, as little as 2.9 mM arginine added to acidified suspensions of Streptococcus sanguis at a pH of 4.0 resulted in ammonia production and protection against killing. The arginine deiminase system was found to have unusual acid tolerance in a variety of lactic acid bacteria. For example, for Streptococcus rattus FA-1, the pH at which arginolysis was reduced to 10% of the maximum was between 2.1 and 2.6, or more than 1 full pH unit below the minimum for glycolysis (pH 3.7), and more than 2 units below the minimum for growth in complex medium (pH 4.7). The acid tolerance of the arginine deiminase system appeared to be primarily molecular and to depend on the tolerance of individual enzymes rather than on the membrane physiology of the bacteria; pH profiles for the activities of arginine deiminase, ornithine carbamoyltransferase, and carbamate kinase in permeabilized cells showed that the enzymes were active at pHs of 3.1 or somewhat lower. Overall, it appeared that ammonia could be produced from arginine at low pH values, even by cells with damaged membranes, and that the ammonia could then protect the cells against acid damage until the environmental pH value rose sufficiently to allow for the reestablishment of a difference in pH (delta pH) across the cell membrane.
Development of the Blood-Based Alzheimer's Disease Liquid Biopsy (2019)

Cancer, diabetes, immune system and neurodegenerative diseases, such as Alzheimer’s disease (AD), are biologically and genetically heterogeneous entities characterized by complex and non-linear pathomechanistic alterations.
JCESR Scientific Sprints – Better Polymers for Better Batteries (2016)

Argonne National Laboratory leads the Joint Center for Energy Storage Research (JCESR), a major collaborative research partnership with the goal of developing next-generation energy storage technologies. JCESR supplements its traditional project management approach with scientific “Sprints.” The Sprint described in this video involved a multidisciplinary team from Argonne, the University of Illinois at Urbana-Champaign, Massachusetts Institute of Technology, and the University of Michigan. As they studied how polymers in solution can react electrochemically to store energy, the team solved a crucial battery problem: “crossover,” which is caused by molecules mixing together when they should not, resulting in reduced performance. Many possible materials were tested, and a set of candidate polymers were chosen that are stable, cheap to make, and suitable for conditions required in batteries. The collaboration allowed timely development that would have taken much longer had the groups been working independently.
Estimation of the Shock to Detonation Region Inside an Energetic Material (2015)

A series of six tests were conducted investigating the shock-to-detonation transition (SDT) in cylindrical samples of HE with a wax binder. A 40 mm powder gun was used to launch spherical steel fragments at a mean velocity of 1519 m/s into the HE. For each test 9 piezoelectric pins were placed just below the surface of the HE and situated to form a plane that bisects the HE sample. The pins were positioned such that 8 were along the side of the cylinder with the 9th pin opposite the impact location of the cylinder. The 9 pins were used to record the detonation wave time of arrival (TOA). Using the piezoelectric pin TOA a basic kinematic equation can be written for the velocity between the start of the detonation wave and the TOA at the pin. A system of 4 equations is used to solve for the location in the plane, the velocity, and time when the detonation wave initiated. This approach was used for each unique combination of piezoelectric pins to estimate a region where the SDT transition occurred.
On the $X$-ray transform of planar symmetric 2-tensors (2015)

In this paper we study the attenuated $X$-ray transform of 2-tensors supported in strictly convex bounded subsets in the Euclidean plane. We characterize its range and reconstruct all possible 2-tensors yielding identical $X$-ray data. The characterization is in terms of a Hilbert-transform associated with $A$-analytic maps in the sense of Bukhgeim.
Modeling Task-Aware MIMO Cardinality for Efficient Multilingual Neural Machine Translation (2021)

Hongfei Xu, Qiuhui Liu, Josef van Genabith, Deyi Xiong. Proceedings of the 59th Annual Meeting of the Association for Computational Linguistics and the 11th International Joint Conference on Natural Language Processing (Volume 2: Short Papers). 2021.