gebhart/patrepeval huggingface dataset:
Vaccine effectiveness of the 7-valent and 13-valent pneumococcal conjugate vaccines in Canada: An IMPACT study (2022)

We used an indirect cohort analysis in children under 5 years-old from 2002 to 2018 to examine vaccine effectiveness (VE) of the 7-valent pneumococcal conjugate vaccine (PCV) (3 + 1 doses in most regions) and the 13-valent PCV (2 + 1 doses in all regions) against invasive pneumococcal disease (IPD) caused by vaccine serotypes in children in Canada. Cases were identified from the Canadian Immunization Monitoring Program ACTive (IMPACT), a national active surveillance network of 12 tertiary care pediatric hospitals that represent about 90% of tertiary care hospital beds in Canada. There were 1477 children evaluated for PCV7 VE and 489 for PCV13 VE. PCV7 VE in children with vaccination up to date for their age was 96% (95% CI: 67-99%) after a single dose and 95% (95% CI: 92-97%) after ≥2 doses. The VE was 91% (95% CI: 85-94%) in children who had received doses but were not up to date for their age. PCV13 VE in children with vaccinations up to date for their age was 55% (95% CI: 28-72%) after ≥2 doses. The PCV13-vaccine serotypes causing breakthrough IPD in children up to date for their age with 2+ doses of PCV13 were 3 (13/27, 48.2%),19A (11/27, 40.7%), and 19F (3/27, 11.1%). When serotype 3 and 19A were excluded, the VE of PCV13 against the remaining vaccine serotypes was 89% (95% CI: 64-97%) in children with ≥2 doses. The lower VE of PCV13 may be due to lower effectiveness against serotypes 3 and 19A, which could be influenced by the change in dosing schedule from 4 to 3 total doses with the introduction of PCV13, combined with vaccine uptake of 80%. However, PCV13 still provides the benefit of protection against more serotypes than PCV7, and good VE against all serotypes except 3 and 19A.
Mapping of the functional active site of Baeyer–Villigerases by substrate engineering (1995)

An active site model for enzyme catalysed Baeyer–Villiger reactions is proposed and validated by transformation of the tricyclic ketone 6; Baeyer–Villiger reactions (and Baeyer–Villigerases) are classified by the stereochemistry of the hydroxyperoxide intermediate.
Theory and Measurements of a Compact High Dielectric Microstrip Rotman Lens (1992)

A compact microstrip lens operating at frequencies between 1.33 and 4 GHz was designed and tested. The measurements included the complete scattering matrix as well as the multibeam radiation patterns. In addition, a contour integral equation formulation was developed to predict the S-matrix associated with the lens. The model incorporates higher order propagation modes as well as the tapered transitions that transform the 50 Ω transmission lines to the larger lens apertures. This paper discusses problems associated with the lens design and manufacture of the tapered transitions, describes the lens model, compares measured S-parameters with theoretical predictions, and presents the resultant radiation patterns with the lens connected to an array of wideband, notched, stripline antenna elements.
Binder, a logic-based security language (2005)

We introduce the concept of a security language, used to express security statements in a distributed system. Most existing security languages encode security statements as schematized data structures, such as ACLs and X.509 certificates. In contrast, Binder is an open logic-based security language that encodes security statements as components of communicating distributed logic programs. Binder programs can be more expressive than statements in standard security languages, and the meanings of standard security constructs and operations such as certificates and delegation are simplified and clarified by their formulation in Binder. Translation into Binder has been used to explore the design of other new and existing security languages.
ChemInform Abstract: Synthesis and Polarographic Behavior of 2H‐Isoindole‐4,7‐diones. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Efficient Modelling of FPGA-based IP blocks using Neural Networks (2016)

International audience
A growing family: the expanding universe of the bacterial cytoskeleton (2011)

Cytoskeletal proteins are important mediators of cellular organization in both eukaryotes and bacteria. In the past, cytoskeletal studies have largely focused on three major cytoskeletal families, namely the eukaryotic actin, tubulin, and intermediate filament (IF) proteins and their bacterial homologs MreB, FtsZ, and crescentin. However, mounting evidence suggests that these proteins represent only the tip of the iceberg, as the cellular cytoskeletal network is far more complex. In bacteria, each of MreB, FtsZ, and crescentin represents only one member of large families of diverse homologs. There are also newly identified bacterial cytoskeletal proteins with no eukaryotic homologs, such as WACA proteins and bactofilins. Furthermore, there are universally conserved proteins, such as the metabolic enzyme CtpS, that assemble into filamentous structures that can be repurposed for structural cytoskeletal functions. Recent studies have also identified an increasing number of eukaryotic cytoskeletal proteins that are unrelated to actin, tubulin, and IFs, such that expanding our understanding of cytoskeletal proteins is advancing the understanding of the cell biology of all organisms. Here, we summarize the recent explosion in the identification of new members of the bacterial cytoskeleton and describe a hypothesis for the evolution of the cytoskeleton from self-assembling enzymes.
Magnitudes and Orientations of the Principal Elements of the 1H Chemical Shift, 1H−15N Dipolar Coupling, and 15N Chemical Shift Interaction Tensors in 15Nε1-Tryptophan and 15Nπ-Histidine Side Chains Determined by Three-Dimensional Solid-State NMR Spectroscopy of Polycrystalline Samples (1997)

The magnitudes and orientations of the principal elements of the 1H chemical shift, 1H−15N dipolar coupling, and 15N chemical shift interaction tensors in 15Nε1-tryptophan and 15Nπ-histidine nitrogen sites were determined by the analysis of three-dimensional powder patterns obtained from 15N-labeled powder samples of the amino acids. Although the magnitudes of the principal elements of the 1H and 15N chemical shift tensors for these two sites are quite different, their molecular orientations in the molecular frame are very similar. The least shielded 15N chemical shift tensor element, σ33N, and the most shielded 1H chemical shift tensor element, σ11H, are approximately colinear with the N−H bond in both cases. The principal elements, σ22H and σ22N, are in the plane of the indole ring for tryptophan and in the plane of the imidazole ring for histidine but oppose each other. σ11N and σ33H are perpendicular to the planes of these heterocyclic rings. The chemical shift tensors of the 1H and 15N nuclei in these two side chain nitrogen sites are distinctly different from those of backbone amide nitrogen sites.
ChemInform Abstract: Synthesis and Structure—Activity Relationships of Potential Anticonvulsants Based on 2‐Piperidinecarboxylic Acid and Related Pharmacophores. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Can a modified esophageal stent be useful in the treatment of nonresponsive benign colonic anastomotic stenosis? (2017)

A 77-year-old woman with history of anterior rectal resection for neoplasia in 1998, followed by chemo- and radiotherapy, was referred to our unit because of an increase in subocclusive episodes (1 – 2 times a week) over the previous 5 months, due to a stenosis extending to 5 cm above the colorectal anastomosis. The patient had previously undergone several pneumatic dilation procedures for anastomotic stenosis, with substenosis of the colon above, following radiotherapy.
Essential Role of P-Selectin in the Initiation of the Inflammatory Response Induced by Hemorrhage and Reinfusion (1999)

Resuscitation from hemorrhage induces profound pathophysiologic alterations and activates inflammatory cascades able to initiate neutrophil accumulation in a variety of tissues. This process is accompanied by acute organ damage (e.g., lungs and liver). We have previously demonstrated that significant leukocyte-endothelium interactions occur very early in other forms of ischemia/reperfusion (i.e., splanchnic ischemia/reperfusion and traumatic shock) which are largely mediated by increased expression of the adhesion molecule, P-selectin, on the vascular endothelium. Here we postulated that increased endothelial expression of P-selectin in the microvasculature would play an essential role in initiating the inflammatory signaling of hemorrhagic shock. Using intravital microscopy, we found that hemorrhagic shock significantly increased the number of rolling and adherent leukocytes in the mouse splanchnic microcirculation. In contrast, mice genetically deficient in P-selectin, or wild-type mice given either an anti-P-selectin monoclonal antibody or a recombinant soluble P-selectin glycoprotein ligand (PSGL)-1 immunoglobulin, exhibited markedly attenuated leukocyte-endothelium interaction after hemorrhagic shock. Thus, activation of P-selectin protein on the microvascular endothelium is essential for the initial upregulation of the inflammatory response occurring in hemorrhagic shock. Moreover, endogenous levels of PSGL-1 mRNA were significantly increased in the lung, liver, and small intestine of wild-type mice subjected to hemorrhagic shock. Since PSGL-1 promotes adhesive interactions largely through P-selectin expressed on the vascular endothelium, this result further supports the crucial role played by P-selectin in the recruitment of leukocytes during hemorrhagic shock.
Vapor pressure and vapor composition of diethylgallium chloride and diethylaluminum chloride (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTVapor pressure and vapor composition of diethylgallium chloride and diethylaluminum chlorideNicholas I. Buchan, Robert M. Potemski, and Thomas F. KuechCite this: J. Chem. Eng. Data 1991, 36, 4, 372–374Publication Date (Print):October 1, 1991Publication History Published online1 May 2002Published inissue 1 October 1991https://doi.org/10.1021/je00004a008RIGHTS & PERMISSIONSArticle Views73Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (373 KB) Get e-Alerts Get e-Alerts
Introduction to Software Design for Six Sigma (DFSS) (2010)

This chapter contains sections titled: Introduction Why Software Design for Six Sigma? What is Software Design For Six Sigma? Software DFSS: The ICOV Process Software DFSS: The ICOV Process In Software Development DFSS versus DMAIC A Review of Sample DFSS Tools by ICOV Phase Other DFSS Approaches Summary Appendix 8.A (Shenvi, 2008) DIDOVM Phase: Define DIDOVM Phase: Identify DIDOVM Phase: Design DIDOVM Phase: Optimize DIDOVM Phase: Verify DIDOVM Phase: Monitor References
CYP1A2 Genetic Polymorphisms are Associated with Treatment Response to the Antidepressant Paroxetine (2010)

Genetic variants in the CYP1A2 region may be indicators of treatment response in MDD patients to paroxetine.
4(And 5)‐cyclopropylamino‐5(and 4)halo‐3(2H)pyridazinones. Formation and characterization of isomers (1977)

Abstract The reactions of 4,5‐dihalo‐3(2 H )pyridazinones with ammonia and amines gave mixtures of 5‐amino‐4‐halo‐ and 4‐amino‐5‐halo‐3(2 H )pyridazinones separated by chromatography. Structures were elucidated by means of retention values (R f ) and confirmed by independent synthesis.
High Content Screening, a reliable system for Coxiella burnetii isolation from clinical samples (2019)

Abstract Q fever, caused by Coxiella burnetii , is a worldwide zoonotic disease that may cause severe forms in humans and requires a specific and prolonged antibiotic treatment. Although the current serological and molecular detection tools enable a reliable diagnosis of the disease, culture of C. burnetii strains is mandatory to evaluate their antibiotic susceptibility and sequence their genome in order to optimize patient management and epidemiological studies. However, cultivating this fastidious microorganism is difficult and restricted to reference centers as it requires biosafety-level 3 laboratories and relies on cell culture performed by experienced technicians. In addition, the culture yield is low, which results in a small number of isolates being available. In this work, we developed a novel high content screening (HCS) isolation strategy based on optimized high-throughput cell culture and automated microscopic detection of infected cells with specifically-designed algorithms targeting cytopathic effects. This method was more efficient than the shell-vial assay when applied to both frozen specimens (7 isolates recovered by HCS only, sensitivity 91% vs 78% for shell-vial) and fresh samples (1 additional isolate using HCS, sensitivity 7% vs 5% for shell-vial). In addition, detecting positive cultures by an automated microscope reduced the need for expertise and saved 24% of technician working time. Application of HCS to antibiotic susceptibility testing of 12 strains demonstrated that it was as efficient as the standard procedure that combines shell-vial culture and quantitative PCR. Overall, this high-throughput HCS system paves the way to the development of improved cell culture isolation of human viruses.
Expression of a Parathyroid Hormone-Like Protein and Its Receptor during Differentiation of Embryonal Carcinoma Cells (1990)

Differentiation of mouse embryonal carcinoma cells to the parietal endoderm phenotype is associated with expression of PTH-responsive adenylate cyclase. A PTH-like protein (PLP), which binds to PTH receptors and activates adenylate cyclase in classical PTH target cells was recently isolated and cloned. We assessed whether the parietal endoderm phenotype is associated with the expression of PLP or its receptor. A 1.4-kilobase PLP transcript was detected in the mouse parietal endoderm cell line PYS-2. No hybridizing transcripts were evident in undifferentiated mouse embryonal carcinoma cells PSA-1 or F9. However, differentiation of these cells to parietal endoderm, either spontaneously (PSA-1) or by treatment with retinoic acid and dibutyryl cAMP (F9), resulted in expression of the 1.4-kilobase PLP message. Undifferentiated F9 cells displayed negligible specific binding of [125I]PLP-(1-34)amide. When F9 cells were induced to differentiate to parietal endoderm, specific binding sites for [125I]PLP-(1-34)amide were expressed in parallel with PLP-responsive adenylate cyclase. These receptors, like those in classical PTH target tissues, displayed identical affinity (Kd = 5.2 nM) for bPTH-(1-34) and hPLP-(1-34)amide; with binding capacity (Bmax) of 6.6 x 10(4) sites/cell. In the presence of retinoic acid, exogenous PLP substituted for dibutyryl cAMP in a concentration-dependent fashion in promoting the differentiation of F9 cells to parietal endoderm. Thus, both PLP mRNA and PLP receptors coupled to adenylate cyclase are expressed during the differentiation of mouse embryonal carcinoma cells. Increased cAMP levels produced by autocrine stimulation of PLP receptors by PLP may contribute to differentiation of embryonal carcinoma cells into parietal endoderm.
Application of RBF Neural Network Based on Wavelet Packet denosing and EMD method in fault diagnosis for turbine generator (2010)

Because the process of fault diagnosis for turbine generator usually contains noise and has a characteristic of strongly non-linear and non-stationary. In this paper, to overcome the deficiency of existing methods, a new approach for fault diagnosis of turbine generator based on wavelet packet denoising ,EMD method and RBF neural network is proposed. Firstly, the fault data of turbine generator is analyzed using wavelet packet to remove the noise; Then the denoised data is disposed by EMD method to extract the frequency eigenvectors of the IMF components, and these eigenvectors were used as the training samples of the RBF network. Finally, use the well-trained RBF network to identify the faults. The simulation experiments show that the proposed method of fault diagnosis for turbine generator is effective and the denosing using wavelet packet transform is essential.
Antioxidant plasticity and thermal sensitivity in four types of Symbiodinium sp. (2014)

Warmer than average summer sea surface temperature is one of the main drivers for coral bleaching, which describes the loss of endosymbiotic dinoflagellates (genus: Symbiodinium) in reef-building corals. Past research has established that oxidative stress in the symbiont plays an important part in the bleaching cascade. Corals hosting different genotypes of Symbiodinium may have varying thermal bleaching thresholds, but changes in the symbiont's antioxidant system that may accompany these differences have received less attention. This study shows that constitutive activity and up-regulation of different parts of the antioxidant network under thermal stress differs between four Symbiodinium types in culture and that thermal susceptibility can be linked to glutathione redox homeostasis. In Symbiodinium B1, C1 and E, declining maximum quantum yield of PSII (Fv /Fm ) and death at 33°C were generally associated with elevated superoxide dismutase (SOD) activity and a more oxidized glutathione pool. Symbiodinium F1 exhibited no decline in Fv /Fm or growth, but showed proportionally larger increases in ascorbate peroxidase (APX) activity and glutathione content (GSx), while maintaining GSx in a reduced state. Depressed growth in Symbiodinium B1 at a sublethal temperature of 29°C was associated with transiently increased APX activity and glutathione pool size, and an overall increase in glutathione reductase (GR) activity. The collapse of GR activity at 33°C, together with increased SOD, APX and glutathione S-transferase activity, contributed to a strong oxidation of the glutathione pool with subsequent death. Integrating responses of multiple components of the antioxidant network highlights the importance of antioxidant plasticity in explaining type-specific temperature responses in Symbiodinium.
Alpha7 nicotinic acetylcholine receptor is required for blood-brain barrier injury-related CNS disorders caused by Cryptococcus neoformans and HIV-1 associated comorbidity factors (2015)

Collectively, our data suggest that α7 nAChR plays a detrimental role in the host defense against C. neoformans- and HIV-1 associated comorbidity factors-induced BBB injury and CNS disorders.
Modeling Thin Film CdS Development in a Chemical Bath Deposition Process (2000)

The chemical bath deposition (CBD) process is currently favored for the preparation of CdS thin films of commercial interest. A chemical engineering type analysis of the CBD process is carried out in this paper to aid its design and optimization. Model equations are developed (based on a population balance formulation) for the temporal variation of reactant concentrations as well as of the solid phase, both in the bulk and on the substrate. A possible sequence of elementary mechanisms (i.e., nucleation, surface reaction, etc.) is suggested, and the resulting comprehensive model is solved numerically. Computational results show that the model is consistent with available experimental data on film thickness evolution. Furthermore, the influence of the process parameters on the results is studied theoretically and discussed extensively for several cases. The model may prove very useful for optimization of the CBD process with respect to its design variables (reactant concentrations, process time, etc.) as well as for efficient experimental determination of presently uncertain or missing parameter values.
Stem Cells for Myocardial Regeneration (2010)

The feld of regenerative medicine is in its infancy state. Enthusiasm for the potential of organ regeneration lies with the potential pluripotency of stem cells to differentiate into various tissue ty
Aerobic oxidative N-dealkylation of tertiary amines in aqueous solution catalyzed by rhodium porphyrins (2012)

Aerobic oxidative N-dealkylation of a variety of aliphatic tertiary amines and anilines catalyzed by rhodium(III) tetra (p-sulfonatophenyl) porphyrin ((TSPP)Rh(III)) is achieved in aqueous solution using dioxygen as the sole oxidant.
Beauty food activities of wild-cultivated Ginseng (Panax ginseng C.A. Meyer) ground part (2018)

This study aimed to investigate the beauty food activities of wild-cultivated ginseng (Panax ginseng C.A. Meyer). wild-cultivated ginseng extracts were analyzed for antioxidant, skin whitening, anti-wrinkle effect was measured in water and 70% ethanol extract. The 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging and 2,2'-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical decolorization activities of water and 70% ethanol extracts were 16.69 and 2.18% as well as 4.04 and 3.25% at a solid content of 200 g/mL, respectively. The antioxidant protection factors (PF) of water and 70% ethanol extracts at a solid content of 200 g/mL were 1.06 PF and 1.09 PF, respectively. Thiobarbituric acid reactive substance (TBARs) were both 96% at a solid content of 200 g/mL. As PF and TBARs showed higher activity than DPPH and ABTS, we could know that antioxidant activity in the lipophilic component of wood-cultivated ginseng were superior to water-soluble component of wood-cultivated ginseng. Tyrosinase inhibitory activity was 10.97 and 52.39% in water and 70% ethanol extracts at a solid content of 200 g/mL. The collagenase and elastase inhibitory activities as anti-wrinkle effect were 15.71 and 20.43% in water extracts as well as 32.26 and 86.74% in 70% ethanol extract at a solid content of 200 g/mL. The results show that anti-wrinkle effect was the best among the other experiments. This extracts from wood-cultivated ginseng, therefore, seems to be a potent beauty food resource against wrinkles.