gebhart/patrepeval huggingface dataset:
Postglacial sedimentary regime around northern Sylt, South-eastern North Sea, based on shallow seismic profiles (2010)

During the past 5 years the coastal zone offshore the northern part of the island of Sylt, has been investigated by sparker seismics and high-resolution subbottom profiling. The North Sea sector of the area is characterized by northward-directed sediment bypass as a result of strong long-shore (tidal) currents heading towards the Lister Tief. The southern part of Lister Tief is characterized by the presence of a major dune field with up to 8 m high compound dunes with wavelengths up to 350 m indicative of easterly-directed sediment transport (flood dominated). Further to the northwest, in the outer delta, a dune field suggesting westerly-directed sediment transport is identified. The two dune fields appear to be separated by minor indefinite bed forms. The northern part of the Lister Tief is characterised by the presence of a channel with a depth of 20-30 mbsf (meter below sea level) (30-40 msec TWT (Two Way Traveltime)) and displaying erosion towards the north. At the western termination of the channel the sediment transport pathway appears to be divided into two directions; one towards the outer delta, and one towards the sediment depocenter SW of Rømø. The Lister Ley is characterized by the presence of minor dunes, indicative of flood-current control, apart from a central zone where ebb-tide is responsible for northward-directed sediment transport. Sparker seismic and Chirp III data are consistent with processes having been persistent throughout the Holocene. Based on the study a model for the current direction and sedimentation regime is suggested.
Scheduling tests for VLSI systems under power constraints (1997)

This paper considers the problem of testing VLSI integrated circuits in minimum time without exceeding their power ratings during test. We use a resource graph formulation for the test problem. The solution requires finding a power-constrained schedule of tests. Two formulations of this problem are given as follows: (1) scheduling equal length tests with power constraints and (2) scheduling unequal length tests with power constraints. Optimum solutions are obtained for both formulations. Algorithms consist of four basic steps. First, a test compatibility graph is constructed from the resource graph. Second, the test compatibility graph is used to identify a complete set of time compatible tests with power dissipation information associated with each test. Third, from the set of compatible tests, lists of power compatible tests are extracted. Finally, a minimum cover table approach is used to find an optimum schedule of power compatible tests.
Lewis Acid Catalyzed Highly Selective Halogenation of Aromatic Compounds. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Graphical Solution for Arterial Road Traffic Flow Model Considering Spillover (2017)

This research proposes a graphical solution to arterial road dynamics simulation. An arterial road consists of channelized and upstream sections. Traffic flow is mixed in the upstream section (U-section) and operates without lateral interaction in the channelized section (C-section). Under oversaturated conditions, C-section spillover occurrence governs the traffic flow dynamics of the entire road. In order to capture the arterial road traffic flow dynamics, the proposed method takes advantage of the following components: 1) a decomposition mechanism that uniforms the analysis of each lane; 2) a red-green pair-based vehicle queue tracking component that describes traffic dynamics both temporally and spatially; and 3) a well-defined converted cumulative curve that is capable of generating a queue solution directly. The graphical method permits arbitrary traffic flow and signal settings input and can easily be automated, as demonstrated in the example.
Involvement of Drug-Specific T Cells in Acute Drug-Induced Interstitial Nephritis (2006)

Drug-induced interstitial nephritis can be caused by a plethora of drugs and is characterized by a sudden impairment of renal function, mild proteinuria, and sterile pyuria. For investigation of the possible pathomechanism of this disease, drug-specific T cells were analyzed, their function was characterized, and these in vitro findings were correlated to histopathologic changes that were observed in kidney biopsy specimens. Peripheral blood mononuclear cells from three patients showed a proliferative response to only one of the administered drugs, namely flucloxacillin, penicillin G, and disulfiram, respectively. The in vitro analysis of the flucloxacillin-reactive cells showed an oligoclonal immune response with an outgrowth of T cells bearing the T cell receptor Vbeta9 and Vbeta21.3. Moreover, flucloxacillin-specific T cell clones could be generated from peripheral blood, they expressed CD4 and the alphabeta-T cell receptor, and showed a heterogeneous cytokine secretion pattern with no clear commitment to either a Th1- or Th2-type response. The immunohistochemistry of kidney biopsies of these patients revealed cell infiltrations that consisted mostly of T cells (CD4+ and/or CD8+). An augmented presence of IL-5, eosinophils, neutrophils, CD68+ cells, and IL-12 was observed. In agreement with negative cytotoxicity assays, no cytotoxicity-related molecules such as Fas and perforin were detected by immunohistochemistry. The data indicate that drug-specific T cells are activated locally and orchestrate a local inflammation via secretion of various cytokines, the type of which depends on the cytokine pattern secreted and which probably is responsible for the renal damage.
Mechanisms of differential transferrin receptor expression in normal hematopoiesis (2000)

We have investigated the expression of transferrin receptor (TfR) iron regulatory protein-1 (IRP-1) and iron regulatory protein-2 (IRP-2) in liquid suspension culture of purified hematopoietic progenitor cells (HPCs) induced by a growth factor stimulus to proliferation and unilineage differentiation/maturation through the erythroid, granulocytic, monocytic and megakaryocytic lineages. In initial HPC differentiation, TfR expression is induced in both erythroid and granulopoietic cultures. In late HPC differentiation (i.e. starting from day 5 of culture) and then differentiated precursor maturation, the TfR gene is highly expressed in the erythroid lineage, whereas it is sharply downmodulated in the granulopoietic, monocytopoietic and megakaryocytic series. The elevated TfR expression in erythroid cells is: (a) mediated through a high rate of TfR gene transcription; (b) modulated by intracellular iron levels; (c) mediated by TfR mRNA stabilization through the iron regulatory protein (IRP), in that IRP-1 activity is high in erythroid lineage as compared to the levels observed in other hemopoietic lineages; and (d) dependent on exogenous erythropoietin (Epo) (this is indicated by the marked TfR and IRP-1/IRP-2 downmodulation after Epo starvation). Interestingly, analysis of IRP-1 and IRP-2 expression during hemopoietic differentiation showed that: (a) IRP-1 expression was maintained during all steps of erythroid differentiation, while it was lost in the other hemopoietic lineages; (b) IRP-2 expression was observed during all stages of hemopoietic differentiation in all four lineages. However, IRP-1 and IRP-2 expression and activity are induced when monocytes, which express only low levels of IRP-1 and IRP-2, are induced to maturation to macrophages. These studies indicate that: (a) in normal erythropoiesis, the hyperexpression of TfR, starting from early erythroid HPC differentiation, is Epo-dependent and mediated via transcriptional and post-transcriptional mechanisms; (b) in the granulopoietic, monocytopoietic and megakaryocytic pathways, the TfR is first induced and then downmodulated (the latter phenomenon is mediated via transcriptional suppression of the TfR gene and IRP inactivation).
Vitamin D-Intoxicated Patient With Hypoparathyroidism (1964)

A patient presenting with an acute cerebellar ataxia, nausea, and vomiting of approximately one week's duration was found to have a serum calcium of 23.7 mg/100 ml. This was attributed to calcium and vitamin D therapy following previous thyroidectomy on July 3, 1962. Immediately after baseline studies, 20 cc of 50% magnesium sulfate were administered intramuscularly. No further therapy was given. The neurologic findings, as well as the nausea and vomiting, resolved rapidly within 24 hours in conjunction with decreasing serum calcium levels which reached a normal level of 10.9 mg at the end of five days. The urinary calcium excretion in the first 24 hours following MgSO<sub>4</sub>was elevated to 803 mg. The EEG changed from abnormal diffuse slow alpha activity to normal within four days. An elevated spinal fluid protein (58 mg%) returned toward normal (43 mg%) in approximately three weeks. This is believed to be the
Adaptive weighted parallel interference cancellationfor CDMA systems (1998)

A new weighted parallel interference cancellation system is proposed in which the weights are adjusted user by user and adaptively to changing environments. Based on computer simulation results, it is observed that the proposed system outperforms conventional parallel interference cancellation systems.
Fiber Orientation in 3-D Injection Molded Features (1999)

Abstract We present a finite element method for predicting the fiber orientation patterns in 3-D injection molded features, and compare the predictions to experiments. The predictions solve the full balance equations of mass, momentum, and energy for a generalized Newtonian fluid. A second-order tensor is used to describe and calculate the local fiber orientation state. A standard Hele-Shaw molding filling simulation is used to provide inlet boundary conditions for the detailed inite element models, which are limited to the local geometry of each feature. The experiments use automated image analysis of polished cross-sections to determine fiber orientation as a function of position. Predictions compare well with experiments on a transverse rib, where the detailed calculation can be 2-D. Results of a 3-D calculation for a flow-direction rib also show generally good agreement with experiments. Some errors in this latter calculation are caused by not simulating the initial filling of the rib, due to computational limits.
Les glycoprotéines d'enveloppe des virus Parainfluenza : étude structure versus fonctions et développement d'applications diagnostiques et thérapeutiques (2009)

Human parainfluenza viruses (hPIV, family Paramyxoviridae) are respiratory viruses, often responsible ofinfections at the young children, the elderly and also the immuno-deficient patients. These viruses possess twoglycoproteins at the surface of their envelope, that both play a role in the viral entry into the target cell. Thehemagglutinin-neuraminidase glycoprotein (HN) allows the virus to become attached to the cellular receptor. Then, HN activates the second glycoprotein, the protein of fusion (F). This last achieves the fusion betweenthe envelope of the virus and the cellular membrane. The mechanism by which the HN protein activates the Fprotein remains unknowns, despite the recent determination of the glycoprotein structures. Several models arecurrently proposed in the literature. This thesis work was mainly focused on the human parainfluenza virus type 2 (hPIV-2) and the animalparainfluenza virus type 5 (PIV-5) envelope glycoproteins. A first step of this project has consisted to characterize several circulating hPIV-2 strains at the level of theirglycoproteins and to analyze the differences observed in their functional domains. This work has underlined theimportance of the diagnostic tools update especially in the surveillance of these respiratory viruses. A second part of the project has consisted to study one of viral entry steps of parainfluenza viruses, themembrane fusion led by the F glycoprotein, in a PIV-5 viral model This work has shown that it was to a certainextent possible, by a combinative mutagenesis approach, to dissociate the features of F PIV-5. The engineeringof a viral glycoprotein like PIV-5 F could contribute to the development of tools in therapeutic. The first description of PIV-5 in cryo-electron microscopy has been achieved during this work. This work hasrevealed that the morphology of PIV-5, in a state close to its fully hydrated natural state, was less heterogeneousthan what was generally described in the literature. It was possible to calculate the surface density of theglycoproteins, a new and interesting data, regarding to the actual knowledge on parainfluenza viruses viral entrymechanisms. Works done during this thesis were also accompanied by the development of diagnostic and therapeuticapplications
Cuprate phase diagram and the influence of nanoscale inhomogeneities (2017)

The phase diagram associated with cuprate superconductors is complicated by an array of different ground states. The parent material represents an antiferromagnetic insulator, but becomes a high-temperature superconductor upon doping. The underdoped region of the phase diagram is dominated by the so-called pseudogap phenomena, whose understanding presents one of the great challenges for the field. However, another aspect of these complex systems that is frequently overlooked is the tendency to phase separate into nanoscale regions upon hole doping. The overdoped region allowed the authors to examine the influence of the latter on the overall structure of the phase diagram.
Increased mitochondrial function downstream from KDM5A histone demethylase rescues differentiation in pRB-deficient cells (2015)

The retinoblastoma tumor suppressor protein pRb restricts cell growth through inhibition of cell cycle progression. Increasing evidence suggests that pRb also promotes differentiation, but the mechanisms are poorly understood, and the key question remains as to how differentiation in tumor cells can be enhanced in order to diminish their aggressive potential. Previously, we identified the histone demethylase KDM5A (lysine [K]-specific demethylase 5A), which demethylates histone H3 on Lys4 (H3K4), as a pRB-interacting protein counteracting pRB's role in promoting differentiation. Here we show that loss of Kdm5a restores differentiation through increasing mitochondrial respiration. This metabolic effect is both necessary and sufficient to induce the expression of a network of cell type-specific signaling and structural genes. Importantly, the regulatory functions of pRB in the cell cycle and differentiation are distinct because although restoring differentiation requires intact mitochondrial function, it does not necessitate cell cycle exit. Cells lacking Rb1 exhibit defective mitochondria and decreased oxygen consumption. Kdm5a is a direct repressor of metabolic regulatory genes, thus explaining the compensatory role of Kdm5a deletion in restoring mitochondrial function and differentiation. Significantly, activation of mitochondrial function by the mitochondrial biogenesis regulator Pgc-1α (peroxisome proliferator-activated receptor γ-coactivator 1α; also called PPARGC1A) a coactivator of the Kdm5a target genes, is sufficient to override the differentiation block. Overexpression of Pgc-1α, like KDM5A deletion, inhibits cell growth in RB-negative human cancer cell lines. The rescue of differentiation by loss of KDM5A or by activation of mitochondrial biogenesis reveals the switch to oxidative phosphorylation as an essential step in restoring differentiation and a less aggressive cancer phenotype.
Ophthalmic Applications of SLN and NLC (2018)

The focus of this review is on the recent developments in ophthalmic lipid nanoparticles, the rationale for their use, drug loaded SLNs and NLCs, and the characteristic advantages, limitations of this system and recent studies.
Inhibition of prolactin by ergoline congeners (1974)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInhibition of prolactin by ergoline congenersCharles F. Barfknecht, David B. Rusterholz, and Jonathan A. ParsonsCite this: J. Med. Chem. 1974, 17, 3, 308–312Publication Date (Print):March 1, 1974Publication History Published online1 May 2002Published inissue 1 March 1974https://pubs.acs.org/doi/10.1021/jm00249a010https://doi.org/10.1021/jm00249a010research-articleACS PublicationsRequest reuse permissionsArticle Views113Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Surface roughness of MgO thin film and its critical thickness for optimal biaxial texturing by ion-beam-assisted deposition (2011)

We investigated the deposition time dependences of the in-plane grain alignment (Δφ) and the surface roughness (w) of biaxially textured MgO thin films fabricated by ion-beam-assisted deposition (IBAD) and found a strong correlation between them. The time evolution of the surface roughness of IBAD-MgO showed an abrupt increase at the same time corresponding to the beginning of the deterioration in Δφ. The roughness versus thickness profiles obtained under different deposition conditions with different assisting ion-beam currents collapsed to a single curve, even though the deposition rates were significantly different in each condition. This implies that the abrupt increase in roughness occurred at the same thickness—of about 4 nm—irrespective of the deposition rate. The result also indicated that the Δφ deterioration began with the same thickness of about 4 nm. This “critical” thickness of about 4 nm might be related to the completion of the crystallization of the film. Further, deposition beyond the critical thickness, therefore, became merely a homoepitaxial deposition under the “IBAD” condition, which was far from optimal because of the ion bombardment and low temperature (no-heating), and thus Δφ deteriorated. Based on these considerations, we propose an approach to attain a sharp texture in a IBAD-MgO-based biaxial substrate; moreover, we demonstrated this approach using a two-step deposition process.
Discoidins I and II: common and unique regions on two lectins implicated in cell--cell cohesion in Dictyostelium discoideum. (1982)

As Dictyostelium discoideum amoebae differentiate from the noncohesive to the mutually cohesive state, they synthesize two galactose-binding lectins--discoidins I and II--which have been implicated as obligatory components of the morphogenetic cell-cell recognition and cohesion system. These proteins have been shown to have similar amino acid compositions and subunit Mr and overlapping but distinct carbohydrate recognition specificities. We have performed extensive immunochemical and biochemical analyses to study the structural relationships between these two molecules and to eventually identify structural and functional domains. Antisera raised against highly purified preparations of discoidin I and discoidin II were tested for their reactivities against each protein by both immunoprecipitation and double diffusion analyses. The patterns of crossreactivity indicated the presence of shared as well as unique antigenic determinants. This interpretation was supported by two-dimensional thin-layer peptide map analysis and by studies with purified peptides. Of approximately 10-12 peptides observed after exhaustive tryptic digestion of each radioiodinated lectin, 3 appeared to be common to both. These putative common peptides were purified, and the corresponding peptides from discoidins I and II were found to behave identically by two-dimensional thin-layer analysis, gel filtration, and susceptibility to chymotrypsin. The finding of common and unique regions in discoidins I and II suggests analogies with other families of recognition proteins and may have important functional implications for these cell-cell recognition molecules.
Expression Analysis of the Stem Cell Marker Pw1/Peg3 Reveals a CD34 Negative Progenitor Population in the Hair Follicle (2016)

Pw1/Peg3 is a parentally imprinted gene expressed in adult stem cells in every tissue thus far examined including the stem cells of the hair follicle. Using a Pw1/Peg3 reporter mouse, we carried out a detailed dissection of the stem cells in the bulge, which is a major stem cell compartment of the hair follicle in mammalian skin. We observed that PW1/Peg3 expression initiates upon placode formation during fetal development, coincident with the establishment of the bulge stem cells. In the adult, we observed that PW1/Peg3 expression is found in both CD34+ and CD34- populations of bulge stem cells. We demonstrate that both populations can give rise to new hair follicles, reconstitute their niche, and self-renew. These results demonstrate that PW1/Peg3 is a reliable marker of the full population of follicle stem cells and reveal a novel CD34- bulge stem-cell population. Stem Cells 2017;35:1015-1027.