gebhart/patrepeval huggingface dataset:
Phase II dose titration study of regorafenib in progressive unresectable metastatic colorectal cancer (2023)

Regorafenib has shown significant survival benefit as a salvage therapy for colorectal cancer; however, its starting dose has been controversial in recent studies. Therefore, we conducted a prospective study on the efficacy and safety of the dose reduction of regorafenib to 120 mg. Patients received 120 mg regorafenib once per day for 3 weeks, followed by a 1-week off-treatment period. The primary endpoint was the investigator-assessed disease control rate (DCR). Sixty patients were registered, and the DCR was 38.3% with a median progression-free survival of 2.5 months (95% confidence interval [CI] 1.9-3.7) and median overall survival of 10.0 months (95% CI 6.9-15.2). Common grade 3-4 adverse events were hand-foot skin reaction and hypertension (20.0% each). The results of administration of 120 mg regorafenib as the starting dose are consistent with reports from prior phase III trials, which used starting doses of 160 mg. This lower initiating dose of regorafenib may be beneficial to certain patient populations. This clinical trial was registered in the UMIN Clinical Trials Registry (UMIN-CTR number UMIN000018968, registration date: 10/09/2015).
Chemical synthesis of stereospecifically labeled pyridoxamine 5'-phosphate (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemical synthesis of stereospecifically labeled pyridoxamine 5'-phosphateDing Yah Yang, Younan Shih, and Hung Wen LiuCite this: J. Org. Chem. 1991, 56, 8, 2940–2946Publication Date (Print):April 1, 1991Publication History Published online1 May 2002Published inissue 1 April 1991https://pubs.acs.org/doi/10.1021/jo00008a071https://doi.org/10.1021/jo00008a071research-articleACS PublicationsRequest reuse permissionsArticle Views592Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Serum and urine markers of collagen degradation reflect renal fibrosis in experimental kidney diseases (2015)

In particular, urinary markers of MMP-driven collagen degradation, rather than collagen production markers, may represent a novel, specific and non-invasive diagnostic approach to assess kidney fibrosis.
Interpretation and clinical correlation of serological tests in paracoccidioidomycosis (2001)

In order to correlate the findings of two serological tests, double immunodiffusion (IDD) and immunoblotting (IB), with the clinical diagnosis and follow-up of paracoccidioidomycosis (PCM), 325 serum samples from PCM patients were tested at the beginning of specific therapy and after its completion. Group I included 245 PCM patients at the onset of symptoms without treatment. In 221 cases (90.2%) the IDD showed positive reactions and in 24 (9.8%) the results were negative. Of the 24 IDD negative samples, 23 were investigated by IB and were positive. Group II included 80 PCM patients under follow-up after treatment. There were four cases of relapse in which the IDD and IB tests were positive (100%). Among the 76 cases with inactive mycotic infection, the IDD was negative in 71.2% and positive in 28.8%; the IB was positive in all cases (100%). The control group (Group III) included 27 samples from patients with other mycoses, tuberculosis and from healthy individuals. All showed negative IDD tests but positive reactions with IB, which could be abolished by serum dilutions without altering the PCM reactivity. Therefore, the utilization of the IB, an immunoenzymatic method for the diagnosis of PCM, raised the sensitivity to 100%.
Solid-Fuel Regression Rate Behavior of Vortex Hybrid Rocket Engines (2002)

Aseriesofstaticenginee ringswereconductedtoinvestigatethesolid-fuelregressionratebehaviorandoperating characteristicsofvortexhybridrocketengines.Thevortexhybridenginecone gurationischaracterizedbyacoaxial, coswirling, countere owing vortex combustion e eld in a cylindrical fuel port. To generate this e owe eld, oxidizer is injected through a swirl injector located between the aft end of the fuel grain and the inlet to the converging portion of the exit nozzle. Test e rings with thrusts up to 960 N were conducted with gaseous oxygen and hydroxylterminated polybutadiene solid fuel. Average fuel regression rates up to seven times larger than those in similar classical hybrids were measured. Empirical correlations were developed to describe accurately the experimental regression rates over more than an order of magnitude variation in mass e ux. In addition to local mass e ux and oxygeninjectionvelocity,geometricenginevariables,suchasenginecontractionratioand length-to-diameterratio, had a signie cant ine uence on the measured regression rates. Nondimensional regression rate and heat transfer correlations were also developed. Throttling and restart capability were demonstrated. Nomenclature A = cross-sectional area, cm 2 B = blowing parameter cp = isobaric specie c heat, J/kg ¢K D = port diameter, cm Ea = activation energy, kcal/mole G = local mass e ux, kg/m 2 ¢s Ginj = injection mass velocity, kg/m 2 ¢s GO = gaseous oxygen mass e ux, kg/m 2 ¢s
ChemInform Abstract: The Chemistry and Biology of Syringolins, Glidobactins and Cepafungins (Syrbactins) (2011)

Abstract Review: 53 refs.
<title>New methods for digital halftoning and inverse halftoning</title> (2001)

Halftoning is the rendition of continuous-tone pictures on bi-level displays. Here we first review some of the halftoning algorithms which have a direct bearing on our paper and then describe some of the more recent advances in the field. Dot diffusion halftoning has the advantage of pixel-level parallelism, unlike the popular error diffusion halftoning method. We first review the dot diffusion algorithm and describe a recent method to improve its image quality by taking advantage of the Human Visual System function. Then we discuss the inverse halftoning problem: The reconstruction of a continuous tone image from its halftone. We briefly review the methods for inverse halftoning, and discuss the advantages of a recent algorithm, namely, the Look Up Table (LUT)Method. This method is extremely fast and achieves image quality comparable to that of the best known methods. It can be applied to any halftoning scheme. We then introduce LUT based halftoning and tree-structured LUT (TLUT)halftoning. We demonstrate how halftone image quality in between that of error diffusion and Direct Binary Search (DBS)can be achieved depending on the size of tree structure in TLUT algorithm while keeping the complexity of the algorithm much lower than that of DBS.
Experimental antiulcer drugs. 3. Some unusual transformations of the cyclopenta[c] pyrroles (1977)

Abstract The cyclopenta[ c ]pyrrole‐4‐carbonitrile ( 3 ) is transformed by hyrlroxylamine in hot alcohol to 4,5,6,6a‐tetrahydro‐l‐imino‐3,5,5,6a‐tetramethyl‐4‐cyclopenta[ c ]pyrrole methyl ketone oxime ( 5 ) in contrast to the cyclopentapyrrole 10 which afforded 1,2‐diacetyl‐3,3,5,5‐tetramethyl‐cyclopentene dioxime ( 11 ). The cyclopenta[ c ]pyrrole‐4‐carboxamide 1 ( R = C 6 H 5 ) yielded the isomeric 2a,3,4,4a,5,6,6a,6b‐octahydro‐2a,4,4,6a‐tetramethyl‐5‐(phenylimino)pentaleno[1,6‐ bc ]‐pyrrol‐2‐(1 H )one ( 12 ) in hot dilute hydrochloric acid or hot 99% phosphoric acid. The amide 1 (R = C 6 H 5 ) was transformed in the solid state by oxygen over a period of several months to a mixture of the isomeric anils, 13 and 14 of 1,7‐diacetyl‐7‐hydroxy‐4,6,6‐trimethyl‐2‐azabicyclo‐[2.2.l.]heptan‐3‐one( 16 ).
Ordered Silver and Copper Nanorod Arrays for Enhanced Raman Scattering Created via Guided Oblique Angle Deposition on Polymer (2014)

We report the manufacture of ordered silver and copper nanorod arrays for surface-enhanced Raman scattering using oblique angle deposition (OAD) on prepatterned polymer sheets. It was found that the patterned polymer substrate defined nucleation sites which guided subsequent growth of nanorods. Enhanced surface-enhanced Raman spectroscopy (SERS) intensities of the Raman probe molecule trans-1,2-bis(4-pyridyl)ethylene (BPE) were found for Ag arrays on polymer, up to about 10 times that of the Ag–silica control. The SERS response of Ag nanorod arrays of different structures was investigated alongside results obtained from discrete dipole approximation simulations. This revealed that narrow gaps between nanorods, formed by guided nucleation during OAD, were responsible for this dramatic enhancement. Ordered Cu nanorod arrays were also successfully fabricated, producing a SERS intensity about 3 times that of Cu on silicon for both BPE and another Raman probe—rhodamine B isothiocyanate (RBITC)—highlighting the potential of this large-scale, low-cost, SERS-active substrate.
Low cost plenoptic camera for 3D modelling (2016)

A method for processing plenoptic images and reconstructing 3D models of real objects is presented in this paper. The reconstruction of the object is made by using the capability of the plenoptic camera to perceive the depth. Through six shots, which shoot the object in a central perspective, it will be shown how it is possible to recreate the object in a digital 3D space, in its entirety, at low computational complexity.
Repair-related molecular changes during recovery phase of ischemic stroke in female rats (2022)

Spontaneous recovery after ischemic stroke in female rats was coincided by a difference observed in the expression of molecular markers. The alteration of these markers might be of importance to address future therapeutic strategies.
Small hepatocellular carcinoma: treatment with US-guided intratumoral injection of acetic acid. (1994)

PAI may prove to be an effective therapy for small HCC.
The graph neural networking challenge (2021)

During the last decade, Machine Learning (ML) has increasingly become a hot topic in the field of Computer Networks and is expected to be gradually adopted for a plethora of control, monitoring and management tasks in real-world deployments. This poses the need to count on new generations of students, researchers and practitioners with a solid background in ML applied to networks. During 2020, the International Telecommunication Union (ITU) has organized the "ITU AI/ML in 5G challenge", an open global competition that has introduced to a broad audience some of the current main challenges in ML for networks. This large-scale initiative has gathered 23 different challenges proposed by network operators, equipment manufacturers and academia, and has attracted a total of 1300+ participants from 60+ countries. This paper narrates our experience organizing one of the proposed challenges: the "Graph Neural Networking Challenge 2020". We describe the problem presented to participants, the tools and resources provided, some organization aspects and participation statistics, an outline of the top-3 awarded solutions, and a summary with some lessons learned during all this journey. As a result, this challenge leaves a curated set of educational resources openly available to anyone interested in the topic.
In utero Exposure to Genotoxicants Leading to Genetic Mosaicism: An Overlooked Window of Susceptibility in Genetic Toxicology Testing? (2019)

In utero development represents a sensitive window for the induction of mutations. These mutations may subsequently expand clonally to populate entire organs or anatomical structures. Although not all adverse mutations will affect tissue structure or function, there is growing evidence that clonally expanded genetic mosaics contribute to various monogenic and complex diseases, including cancer. We posit that genetic mosaicism is an underestimated potential health problem that is not fully addressed in the current regulatory genotoxicity testing paradigm. Genotoxicity testing focuses exclusively on adult exposures and thus may not capture the complexity of genetic mosaicisms that contribute to human disease. Numerous studies have shown that conversion of genetic damage into mutations during early developmental exposures can result in much higher mutation burdens than equivalent exposures in adults in certain tissues. Therefore, we assert that analysis of genetic effects caused by in utero exposures should be considered in the current regulatory testing paradigm, which is possible by harmonization with current reproductive/developmental toxicology testing strategies. This is particularly important given the recent proposed paradigm change from simple hazard identification to quantitative mutagenicity assessment. Recent developments in sequencing technologies offer practical tools to detect mutations in any tissue or species. In addition to mutation frequency and spectrum, these technologies offer the opportunity to characterize the extent of genetic mosaicism following exposure to mutagens. Such integration of new methods with existing toxicology guideline studies offers the genetic toxicology community a way to modernize their testing paradigm and to improve risk assessment for vulnerable populations. Environ. Mol. Mutagen. 61:55-65, 2020. © 2019 The Authors. Environmental and Molecular Mutagenesis published by Wiley Periodicals, Inc. on behalf of Environmental Mutagen Society.
CAVE2 documentary (2014)

This video describes the CAVE2 Hybrid Reality Environment developed by the Electronic Visualization Laboratory (EVL) at the University of Illinois at Chicago (UIC). CAVE2 is a near-seamless flat-panel-based, surround-screen immersive system that can simultaneously display both 2D and 3D information, providing more flexibility for mixed media applications and more opportunities for groups of researchers to work together with large heterogeneous datasets [1]. CAVE2 is a cylindrical system of 24 feet in diameter and 8 feet tall, and consists of 72 near-seamless, off-axis-optimized passive-stereo LCD panels, creating a 320-degree panoramic environment for displaying information at 37 Megapixels (in stereoscopic 3D) or 74 Megapixels in 2D and at a horizontal visual acuity of 20/20 [2]. Custom LCD panels with shifted polarizers were built so the images in the top and bottom rows of LCDs are optimized for vertical off-center viewing, allowing viewers to come closer to the displays while minimizing ghosting. EVL's Omegalib middleware supports fully immersive OpenGL, OpenSceneGraph and VTK applications, as well as EVL's SAGE middleware to achieve a hybrid 2D/3D environment. CAVE2 also supports CalVR (developed at the Calit2 Qualcomm Institute at University of California, San Diego), Electro (by Robert Kooima, currently at Louisiana State University) and Google Earth.
Identification and characterization of the human lactoferrin-binding protein from Neisseria meningitidis (1988)

Lactoferrin-binding activity in Neisseria meningitidis was detected by a solid-phase binding assay with horseradish peroxidase-conjugated human lactoferrin (HRP-lactoferrin). Expression of lactoferrin-binding activity was regulated by the level of iron in the medium, so that growth in the presence of the iron chelator EDDA (ethylenediamine di-ortho-hydroxyphenylacetic acid) resulted in a greater than 350-fold increase in binding activity, which was reversed by addition of excess iron. A maximal level of expression could be obtained at reasonable culture densities by using either intermediate levels of EDDA or high levels of EDDA and moderate levels of complexed iron sources such as hemoglobin and transferrin. Competition binding assays demonstrated that the binding of lactoferrin was specific for human lactoferrin in that neither bovine lactoferrin, human transferrin, nor human hemoglobin was able to block binding of HRP-lactoferrin. The binding specificity for human lactoferrin correlated with growth studies in which human but not bovine lactoferrin could support the growth of iron-starved cells. Binding of lactoferrin was not dependent on its level of iron saturation, since iron-saturated lactoferrin and apolactoferrin were equally effective at blocking binding of HRP-lactoferrin in competitive binding assays. The lactoferrin-binding protein was identified as a 105,000-molecular-weight iron-regulated outer membrane protein in three different meningococcal strains by a batch affinity method with biotinylated human lactoferrin and streptavidin-agarose.
Increasing the luminescence of lanthanide complexes (2006)

This review compares the chemical and physical properties of lanthanide ion complexes and of other narrow-emitting species that can be used as labels for cytometry. A series of luminescent lanthanide ion macrocyclic complexes, Quantum Dyes, which do not release or exchange their central lanthanide ion, do accept energy transfer from ligands, and are capable of covalent binding to macromolecules, including proteins and nucleic acids, is described and their properties are discussed. Two methods are described for increasing the luminescence intensity of lanthanide ion complexes, which intrinsically is not as high as that of standard fluorophores or quantum dots. One method consists of adding a complex of a second lanthanide ion in a micellar solution (columinescence); the other method produces dry preparations by evaporation of a homogeneous solution containing an added complex of a second lanthanide ion or an excess of an unbound antenna ligand. Both methods involve the Resonance Energy Transfer Enhanced Luminescence, RETEL, effect as the mechanism for the luminescence enhancement.
Imaging and Spectroscopy of Artificial-Atom States in Core/Shell Nanocrystal Quantum Dots (2001)

Current imaging scanning tunneling microscopy is used to observe the electronic wave functions in InAs/ZnSe core/shell nanocrystals. Images taken at a bias corresponding to the s conduction band state show that it is localized in the central core region, while images at higher bias probing the p state reveal that it extends to the shell. This is supported by optical and tunneling spectroscopy data demonstrating that the s-p gap closes upon shell growth. Shapes of the current images resemble atomlike envelope wave functions of the quantum dot calculated within a particle in a box model.
Verification of LLC resonant converter applied a current-balancing high-frequency transformer with multi-output windings (2014)

DC-DC converters of hybrid vehicles and electric vehicles are required to become smaller and lighter for building roomy and light weight EV. High-frequency switching can be used to miniaturize DC-DC converter. However, the influence of the skin effect and the eddy current become large. Parallel operation of converter is often for current applications using multiple winding transformers in order to reduce of skin effect. However, it is difficult to equalize the each current of converter due to unbalance of winding resistance, drop voltage of diodes and so on. In this paper, the parallel LLC converter applied a current-balancing high-frequency transformer is proposed. The proposed converter can realize nearly equal current even if the stray impedance of secondary circuit of LLC are unbalanced.
Peritoneal Carcinomatosis from Colon Cancer: A Systematic Review of the Data for Cytoreduction and Intraperitoneal Chemotherapy (2015)

A systematic review of the literature on the management of peritoneal carcinomatosis (PC) from colon cancer with cytoreductive surgery (CRS) and intraperitoneal chemotherapy (IPC) was undertaken using OVID Medline. Forty-six relevant studies were reviewed. Mean weighted overall morbidity following CRS and IPC was 49% (range 22-76%) and mortality was 3.6% (range 0-19%). Median overall survival ranged from 15 to 63 months, and 5-year overall survival ranged from 7 to 100%. This represents an improvement over historical treatment with systemic chemotherapy alone, even in the era of modern chemotherapeutic agents. Quality of life following surgery is initially decreased but improves with time and approaches baseline. Available data appear to support the treatment of PC from colon cancer with CRS and IPC. There is a large amount of variability among studies and few high-quality studies exist. Further studies are needed to standardize techniques.
A computer-controlled system for the measurement of complete admittance spectra of piezoelectric resonators (1990)

A measurement system for the characterisation of the electrical properties of piezoelectric resonators is presented. Admittance of the resonator is measured at successive frequencies controlled by an algorithm which uses small frequency steps when a resonance is found, and large steps between the resonances. During the measurement, characteristic frequencies are marked for each resonance. Further evaluation of the data is done by a least-squares fit, which yields the parameters of the equivalent circuit for each resonance in closed form.
Gloss perception in painterly and cartoon rendering (2013)

Depictions with traditional media such as painting and drawing represent scene content in a stylized manner. It is unclear, however, how well stylized images depict scene properties like shape, material, and lighting. In this article, we describe the first study of material perception in stylized images (specifically painting and cartoon) and use nonphotorealistic rendering algorithms to evaluate how such stylization alters the perception of gloss. Our study reveals a compression of the range of representable gloss in stylized images so that shiny materials appear more diffuse in painterly rendering, while diffuse materials appear shinier in cartoon images. From our measurements we estimate the function that maps realistic gloss parameters to their perception in a stylized rendering. This mapping allows users of NPR algorithms to predict the perception of gloss in their images. The inverse of this function exaggerates gloss properties to make the contrast between materials in a stylized image more faithful. We have conducted our experiment both in a lab and on a crowdsourcing Web site. While crowdsourcing allows us to quickly design our pilot study, a lab experiment provides more control on how subjects perform the task. We provide a detailed comparison of the results obtained with the two approaches and discuss their advantages and drawbacks for studies like ours.