gebhart/patrepeval huggingface dataset:
Euplotes crassushas genes encoding telomere-binding proteins and telomere-binding protein homologs (1992)

We have identified two 1.6 kb macronuclear DNA molecules from Euplotes crassus that hybridize to the alpha subunit of the Oxytricha telomere protein. We have shown that one of these molecules encodes the 51 kDa Euplotes telomere protein while the other appears to encode a homolog of the telomere protein. Although this homolog clearly differs in sequence from the Euplotes telomere protein, the two proteins share extensive amino acid sequence identity with each other and with the alpha subunit of the Oxytricha telomere protein. In all three proteins 35-36% of the amino acids are identical, while 54-56% are similar. The most extended regions of sequence conservation map within the N-terminal section; this section has been shown to comprise the DNA-binding domain in the Euplotes telomere protein. Our findings suggest that some of the conserved amino acids may be involved in DNA recognition and binding. The gene encoding the telomere protein homolog contains two introns; one of these introns is only 24 bp in length. This is the smallest mRNA intron reported to date.
Short-term sleep deprivation in mice induces B cell migration to the brain compartment (2019)

Increasing evidence highlight the involvement of immune cells in brain activity and its dysfunction. The brain's immune compartment is a dynamic ensemble of cells that can fluctuate even in naive animals. However, the dynamics and factors that can affect the composition of immune cells in the naive brain are largely unknown. Here, we examined whether acute sleep deprivation can affect the brain's immune compartment (parenchyma, meninges, and choroid plexus). Using high-dimensional mass cytometry analysis, we broadly characterized the effects of short-term sleep deprivation on the immune composition in the mouse brain. We found that after 6 h of sleep deprivation, there was a significant increase in the abundance of B cells in the brain compartment. This effect can be accounted for, at least in part, by the elevated expression of the migration-related receptor, CXCR5, on B cells and its ligand, cxcl13, in the meninges following sleep deprivation. Thus, our study reveals that short-term sleep deprivation affects the brain's immune compartment, offering a new insight into how sleep disorders can affect brain function and potentially contribute to neurodegeneration and neuroinflammation.
Biobehavioral Indices of Emotion Regulation Relate to School Attitudes, Motivation, and Behavior Problems in a Low‐Income Preschool Sample (2006)

Effective emotion regulation may promote resilience and preschool classroom adjustment by supporting adaptive peer interactions and engagement in learning activities. We investigated how hypothalamus-pituitary-adrenal axis (HPA) regulation, cardiac reactivity, and classroom emotion displays related to adjustment among low-income preschoolers attending Head Start. A total of 62 four-year-olds completed a laboratory session including a baseline soothing video; emotion-eliciting slides/video clips, and recovery. Salivary cortisol, heart rate, and vagal tone were measured throughout. Independent coders used handheld computers to observe classroom emotion expression/regulation. Teachers rated child motivation, persistence/attention, learning attitudes, and internalizing/externalizing symptoms. Results reveal associations between biobehavioral markers of regulatory capacity and early school adjustment.
The detection of canine autoantibodies to thyroid antigens by enzyme-linked immunosorbent assay, hemagglutination and indirect immunofluorescence. (1984)

Autoantibodies to thyroid antigens in serums from 34 clinically hypothyroid dogs were detected by various methods. Antibodies to thyroglobulin were detectable by enzyme-linked immunosorbent assay (ELISA) in 59%, by chromic chloride hemagglutination in 53% and by indirect immunofluorescence on formalin-fixed, paraffin-embedded, trypsin-digested thyroid tissue in 73% of samples. Antibody to thyroid microsomal antigen was detectable by ELISA in 29% of serums. Indirect immunofluorescence showed cytoplasmic fluorescence of thyroid follicular cells in several serums, however, this could not be confirmed as specific for microsomal antigen by absorption trials. Hemagglutination tests using commercially available tanned red cells coated with human antigens and indirect immunofluorescence assays on formalin-fixed tissue without trypsin digestion, on Bouin's fixed tissue, or on cryostat, methanol-fixed sections, were insensitive. Cryostat sections without methanol fixation were unsuitable due to tissue fragility. No method was recommended for routine diagnostic use. The ELISA test, because of its convenience, may be useful as a screening aid or adjunct to the diagnosis of thyroid disease.
Development of Species Distribution Models and Evaluation of Species Richness in Jirisan region (2012)

생물다양성에 대한 사회적 관심이 늘어남에 따라 생물다양성 평가, 보호지역 지정, 서식지 관리 및 복원 등 생물자원에 대한 공간적 평가의 필요성이 대두되고 있다. 본 연구는 이러한 야생동물의 서식지에 대한 평가를 위하여 자료의 수집 및 모형화의 기법 연구와 생물종풍부도를 작성하는데 목적이 있다. 종분포모형을 위해 사용된 GAM (Generalized Additive Model)으로 기존의 중첩 분석이나 GLM (Generalized Linear Model)에 비해 환경변수와 반응변수의 관계가 명확하고 이에 따른 해석이 용이하다. 본 연구대상지로는 국립공원, 경관생태보호구역, 수달보호구역으로 지정된 지리산, 백운산, 섬진강을 포함하고 있는 유역을 선정하였다. 대상유역의 토지피복에 따라 층화추출을 통하여 야생동물(포유류와 조류)의 출현/비출현 형태의 현장자료를 수집하였으며, 야생동물의 서식에 영향을 미치는 자연, 사회 경제적 자료를 구축하였다. 각 종에 대한 서식지이용분석과 주요서식인자를 확인한 후, 출현/비출현 모형을 통해 서식지적합성모형을 개발하고, 개별 종에 대한 서식지적합성지도 작성하였다. 서식지 적합성지도를 산술 합산하여 분류군별(포유류, 조류) 종풍부도, 통합종풍부도를 작성하였다. 개별 종 서식지의 주요인자는 서식지선택에 따라 다르게 나타났다. 고라니나 박새와 같은 몇몇 종들은 저지대에 분포하나, 대부분의 포유류나 조류의 잠재서식지는 국립공원 경계구역이나 중산간지역에 많이 분포하였다. 본 연구의 결과는 환경부에서 수행하는 생물다양성의 평가, 보호지역의 지정 등의 기초자료로서 활용될 수 있을 것이다. Increasing concern about biodiversity has lead to a rise in demand on the spatial assessment of biological resources such as biodiversity assessment, protected area selection, habitat management and restoration in Korea. The purpose of this study is to create species richness map through data collection and modeling techniques for wildlife habitat assessment. The GAM (Generalized Additive Model) is easy to interpret and shows better relationship between environmental variables and a response variable than an existing overlap analysis and GLM (Generalized Linear Model). The study area delineated by a large watershed contains Jirisan national park, Mt. Baekun and Sumjin river with three kinds of protected areas (a national park, a landscape ecology protected area and an otter protected area). We collected the presence-absence data for wildlife (mammals and birds) using a stratified random sampling based on a land cover in the study area and implemented natural and socio-environmental data affecting wildlife habitats. After doing a habitat use analysis and specifying significant factors for each species, we built habitat suitability models using a presence-absence model and created habitat suitability maps for each species. Biodiversity maps were generated by taxa and all species using habitat suitability maps. Significant factors affecting each species habitat were different according to their habitat selection. Although some species like a water deer or a great tit were distributed at the low elevation, most potential habitats for mammals and birds were found at the edge of a national park boundary or near a forest around the medium elevation of a mountain range. This study will be used for a basis on biodiversity assessment and proected area selection carried out by Ministry of Environment.
Theory of the anomalously low band-gap pressure coefficients in strained-layer semiconductor alloys (2000)

The band-gap pressure coefficients of III-V ternary semiconductor alloys within strained layers are significantly lower than the bulk binary values and the drop in pressure coefficient, of about $6x\mathrm{m}\mathrm{e}\mathrm{V}/\mathrm{k}\mathrm{b}\mathrm{a}\mathrm{r}$ for ${\mathrm{In}}_{x}{\mathrm{Ga}}_{1\ensuremath{-}x}\mathrm{As}$ grown on GaAs remains unexplained. Linear elasticity has been used to predict first-order (linear) effects of pressure, but for strained layers, this procedure fails to predict the pressure coefficients. We show that the nonlinear elasticity theory is necessary, and when evaluated with a consistent level of approximation throughout, it accounts for the pressure coefficients, largely through an approximately linear increase of Poisson's ratio with pressure. Earlier experimental data and some photoabsorption results for ${\mathrm{In}}_{x}{\mathrm{Ga}}_{1\ensuremath{-}x}\mathrm{As}$ on InP are reviewed and they agree well with values predicted using our analysis.
Phencyclidine Identification by Thin-layer Chromatography: A Rapid Screening Procedure for Emergency Toxicology (1978)

The clinical manifestations of phencyclidine abuse may include bizarre neuropsychiatric symptoms, which may mimic the untoward reactions of a variety of illicit drugs. Specific diagnosis and therapy depend, primarily, upon consideration of this drug followed by its prompt and accurate identification. A rapid modified thin-layer chromatographic technic for the detection and differentiation of phencyclindine from other alkaloids and neutral drugs with similar Rf values in this system is presented.
Efficient mobile content delivery by exploiting user interest correlation (2005)

Accelerating multimedia content delivery to mobile devices is challenging because we must not only address long and unpredictable latency created by the error-prone air interface, but also meet mobility-specific requirements such as efficient terminal power consumption. In this paper, we present a novel architecture for content delivery in the mobile environment (ACME) that significantly accelerates interactive mobile services such as Web browsing. ACME exploits the key concept of user interest correlation (the interest in the same content among different users) to push content to mobile users efficiently. Trace-driven simulations show that ACME achieves 50% effectiveness of content broadcasting by, on average, pushing content to only 0.7% to 6% of all users, thus substantially reducing mobile terminal power consumption. Furthermore, ACME has superior scalability as the push group size increases by only 62% when the total number of users increases by 16 times
AMINOALKYLPYRIDINES 3: SYNTHESIS OF PYRIDYL SUBSTITUTED HYDRAZINES BY BORANE REDUCTION OF HYDRAZONES (2002)

Article AMINOALKYLPYRIDINES 3: SYNTHESIS OF PYRIDYL SUBSTITUTED HYDRAZINES BY BORANE REDUCTION OF HYDRAZONES was published on December 1, 2002 in the journal Heterocyclic Communications (volume 8, issue 6).
Quantitative evaluation of the effects of disinfectants against viruses in suspension experiments. (1984)

Time concentration relations in virus-disinfection by formaldehyde, benzalkonium-chloride, ethanol and isopropanol are evaluated. The exposure time needed to reduce the number of plaque-forming units (PFU) by 10(-3) (99.9%) at a given disinfectant concentration was determined. Influenzavirus, Coxsackie B viruses, Herpesvirus and Mumpsvirus were used in the experiments. Formaldehyde is effective at very low concentrations, provided that sufficient time is allowed for reaction, but has little use in short-term applications. Alcohols act very rapidly at the optimal concentration, but are almost completely ineffective if the reagent is only slightly diluted. Isopropanol does not neutralize entero-viruses to any considerable extent. The effect of the alcohols on viruses is greatly enhanced by the addition of alkali. An 80% (or higher) ethanol solution containing 0.01 n NaOH is very promising as a potent antiviral disinfectant for skin and surface decontamination. Even closely related virus types may differ greatly in their sensitivity to ethanol. The Herpesvirus hominis has a peculiarly high sensitivity to benzalconiumchloride, a sensitivity which is not shared by the Influenzavirus and enteroviruses.
Mouthwashes (2009)

V o l uM E 3 2 | N u M B Er 6 | dE C E M B Er 2 0 0 9 w w w. a u s t ra l i a n p re s c riber.com
Mechanisms for Covalent Immobilization of Horseradish Peroxidase on Ion-Beam-Treated Polyethylene (2012)

The surface of polyethylene was modified by plasma immersion ion implantation. Structure changes including carbonization and oxidation were observed. High surface energy of the modified polyethylene was attributed to the presence of free radicals on the surface. The surface energy decay with storage time after treatment was explained by a decay of the free radical concentration while the concentration of oxygen-containing groups increased with storage time. Horseradish peroxidase was covalently attached onto the modified surface by the reaction with free radicals. Appropriate blocking agents can block this reaction. All aminoacid residues can take part in the covalent attachment process, providing a universal mechanism of attachment for all proteins. The native conformation of attached protein is retained due to hydrophilic interactions in the interface region. The enzymatic activity of covalently attached protein remained high. The long-term activity of the modified layer to attach protein is explained by stabilisation of unpaired electrons in sp(2) carbon structures. A high concentration of free radicals can give multiple covalent bonds to the protein molecule and destroy the native conformation and with it the catalytic activity. The universal mechanism of protein attachment to free radicals could be extended to various methods of radiation damage of polymers.
ChemInform Abstract: Total Synthesis of (.+‐.)‐Breynolide: An Aglycon Derivative of a Potent, Orally Active Hypocholesterolemic Agent. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Scattering of electromagnetic pulses by simple-shaped targets with radar cross section modified by a dielectric coating (1998)

We study the scattering interaction of electromagnetic pulses with a spherical target. The target is a perfectly conducting sphere coated with a thin dielectric layer. Two different hypothetical materials are specified: a lossy dielectric and a dielectric that also has magnetic losses. The monostatic radar cross section (RCS) is computed in each case and we examine the influence of the coating on the RCS. In particular, we compare the RCS of the coated sphere with the (normalized) backscattered power when a large perfectly conducting flat plate coated with the same dielectric layer is illuminated at normal incidence by the same waveform. In particular, we find that except for frequencies below those within the efficiency band of the absorbent material, the normalized RCS of the coated sphere agrees well with the power reflection coefficient of the plate covered with the same kind of coating. For low-frequency incidences, the peaks and dips in the RCS are more prominent for the coated target than they are for the bare one. Analyzing the response of the spherical targets in the combined time-frequency domain we demonstrate that the coating itself, although reducing the RCS could introduce additional resonance features in the target's signature at low frequencies that could be used for target recognition purposes. This observation is also confirmed by a study of the bistatic RCS of these coated objects, which we have displayed in various color graphs.
Optimizations to enhance sustainability of MPI applications (2014)

Ultrascale computing systems are likely to reach speeds of two or three orders of magnitude greater than today's computing systems. However, to achieve this level of performance, we need to design and implement more sustainable solutions for ultra-scale computing systems, at both the hardware and software levels, while understanding sustainability in a holistic manner in order to address challenges in economy-of-scale, agile elastic scalability, heterogeneity, programmability, fault resilience, energy efficiency, and storage. Some solutions could be integrated into MPI, but others should be devised as higher level concepts, less general, but adapted to applicative domains, possibly as programming patterns or libraries. In this paper, we layout some proposals to extend MPI to cover major relevant domains in a move towards sustainability, including: MPI programming optimizations and programming models, resilience, data management, and their usage for applications.
cycloSaligenyl-5-[(E)-2-bromovinyl]-2′-deoxyuridine Monophosphate (cycloSal-BVDUMP) Pronucleotides Active against Epstein–Barr Virus (2001)

New potential nucleotide delivery systems directed against Epstein–Barr virus are represented by the 3′-O-acyl-substituted 5′-O-cycloSaligenyl-5-[(E)-2-bromovinyl]-2′-deoxyuridine monophosphate (cycloSal-BVDUMP) triesters 2 a–h, which are derivatives of the prototype triester 1. At least a few of these compounds showed promising antiviral activity in in vitro tests.
Azidothymidine Downregulates Insulin-Like Growth Factor-1 Induced Lipogenesis by Suppressing Mitochondrial Biogenesis and Mitophagy in Immortalized Human Sebocytes (2021)

These results suggest that azidothymidine downregulates IGF-1-induced lipogenesis by dysregulating the quality of mitochondria through suppression of mitochondrial biogenesis and mitophagy in immortalized human sebocytes. Our study provides early evidence that azidothymidine may be an effective candidate for a new pharmacological agent for controlling lipogenesis in sebocytes.
Degradable Inorganic Polymers (2019)

Abstract This article provides an insight into the development of inorganic polymers as (bio)degradable materials. A particular focus is placed on recent advancements to prepare stable polymers showing stimuli‐responsive degradation, that is which degrade only upon exposure to certain stimuli, with the aim of producing materials, which are stable for their usage lifetime but degrade rapidly thereafter. Firstly, these works are placed in the context of biodegradable polymers in general, as well as state‐of‐the‐art organic polymers showing stimuli‐responsive degradation. Degradable polymers is a field which is currently of great importance, both in advanced biomedical applications for which polymeric materials have become indispensable, but also for ever‐growing societal and environmental concerns regarding the use of biopersistant polymers. The inclusion of inorganic components into polymers can lead to unique properties and responsiveness compared to traditional carbon‐based polymers, as is demonstrated by a number of examples herein including phosphorus and boron‐based polymers and metallopolymers, which degrade or depolymerize in response to specific triggers including visible light and oxidation.
Diazyme Adenosine Deaminase in the Diagnosis of Tuberculous Pleural Effusion: Method Evaluation and Clinical Experiences in a New Zealand Population (2010)

Objectives: We evaluated the Diazyme adenosine deaminase assay (ADA) on a commercial auto analyzer (Abbott CI8000; Abbott Laboratories) and the clinical experiences of pleural fluid ADA over a 6 month period in a New Zealand population. Methods: The ADA assay was evaluated for linearity, precision, interferences, sample stability and accuracy. A retrospective audit of ADA levels in non-transduative pleural fluid from 120 patients over a six month period was conducted. Results: In a New Zealand population, pleural fluid ADA has shown a sensitivity of 100% and specificity of 86% for tuberculous pleural effusions with a positive predictive value of 24% and a negative predictive value of 100% at a cut-off of 30 U/L. Conclusions: The Diazyme ADA assay performs in accordance with manufacturer's claims. There are difference in ADA results when compared to an alternative method and caution is advised when literature based cut-offs are applied to the Diazyme ADA method.
Synergistic toxicity of atrazine and organophosphate insecticides contravenes the response addition mixture model (1997)

Abstract A toxic unit (TU) approach was used to test the response addition model for mixtures of pesticides with differing modes of action. Atrazine was tested in binary and ternary combinations with the organochlorine insecticide methoxychlor and organophosphate insecticide methyl-parathion. Atrazine was also tested in binary combinations with additional organophosphates. The TU for atrazine was set slightly below its water solubility limits (TU = 20 ppm), which is well below its 96-h 50% effective concentration for the fourth instar of the midge, Chironomus tentans. In 96-h acute toxicity tests using C. tentans, atrazine was found to produce synergistic (greater than additive) toxicity in a binary mixture with methyl-parathion. Less than additive toxicity was found for the combination of atrazine with methoxychlor (likely due to the low TU assigned to atrazine). The ternary combination of atrazine + methyl-parathion + methoxychlor was found to be marginally synergistic. Results of toxicity tests with atrazine in binary combinations with other organophosphates indicate more than additive toxicity for all compounds except mevinophos. Possible hypotheses are presented in an attempt to explain the noted synergistic relationship between atrazine and various organophosphorous insecticides. These results suggest that the response addition model does not always accurately predict mixture toxicity for chemicals with differing modes of action.
Simulation-Based Pricing of Mortgage-Backed Securities (2005)

Mortgage-backed-securities (MBS), as the largest investment class of fixed income securities, have always been hard to price. Because of the following reasons, normal numerical methods like lattice methods, or finite difference method for solving PDEs are hard to apply: 1) the path dependence of mortgage pool cash flows; 2) the embedded American call option to prepay; 3) the American put option to default; 4) the fact that mortgage borrower do not/cannot exercise these option optimally. And those reasons make Monte Carlo simulation the best approach to price MBS. A standard MBS pricing framework would consists the following parts: 1) interest rate model; 2) prepayment model, which consists house turnover model and refinance model; 3) OAS model, which captures risk factors from the market price. Those factors are not accounted for in the previous two models. In order to hedge MBS efficiently and effectively, we need to calculate hedging measures quickly and correct. Chen and Fu (2001,2002,2003) has developed some efficient hedging algorithm in the past to perform this task.