gebhart/patrepeval huggingface dataset:
Unexpected low prevalence of FVIII gene inversion in severe hemophilia A patients from north-eastern Italy (1996)

Vianello, F.; Radossi, P.; Tison, T.; Tagariello, G.; Dazzi, F.; Girolami, A. Author Information
Fluorogenic Zn(II) and Chromogenic Fe(II) Sensors Based on Terpyridine-Substituted Tetraphenylethenes with Aggregation-Induced Emission Characteristics (2011)

Terpyridine-containing tetraphenylethenes (TPEs) are synthesized and their optical and metal sensing properties are investigated. They are practically nonluminescent in the solution state but become highly emissive as nanoparticle suspensions in poor solvents or thin films in the solid state, demonstrating a novel phenomenon of aggregation-induced emission (AIE). The emission of the nanoaggregates of TPEs is pH-sensitive: it is decreased and eventually quenched upon protonation of their terpyridine units because of their AIE nature. The TPEs can work as "turn-off" fluorescent chemosensors for metal ions and display different fluorescence responses to various metal ions. A characteristic red shift in the emission spectra is observed in the presence of Zn(2+), which facilitates the discrimination of Zn(2+) from other metal ions. Because of the metal-to-ligand-charge-transfer process, terpyridine-substituted TPEs display an obvious magenta color upon selectively binding with Fe(2+), allowing a rapid identification of Fe(2+) in the aqueous media by naked eyes.
Evaluating a Novel EEG-Based Index for Stroke Detection Under Anesthesia During Mechanical Thrombectomy (2022)

We demonstrated the utility of using AS patients undergoing EVT as a platform for assessing a novel EEG marker for the identification of stroke during anesthesia. Further, large-scale studies in AS patients during EVT and in patients undergoing different surgeries and anesthesia are required to validate the LIR.
A new approach to clock modeling and Kalman filter time and frequency prediction (2002)

An extension of a previously reported Kalman filter prediction algorithm is presented. In this new algorithm, the time variable is added to the clock model so that both the time and the frequency can be predicted. The long-term limitation of the previous prediction algorithm is removed by calculating the aging time constant using nonlinear fitting with the gradient search technique. The measurement noise covariance can be estimated if the process noise covariance is the null matrix.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Topics on CMOS Image Sensors (2005)

Today there exist several applications where a real visible scene needs to be sampled to electrical signals, e.g., video cameras, digital still cameras, and machine vision systems. Since the 1970’s charge-coupled device (CCD) sensors have primarily been used for this task, but during the last decade CMOS image sensors have become more and more popular. The demand for image sensors has lately grown very rapidly due to the increased market for, e.g., digital still cameras and the integration of image sensors in mobile phones. The first out of three included papers presents a programmable multiresolution machine vision sensor with on-chip image processing capabilities. The sensor comprises an innovative multiresolution sensing area, 1536 A/D converters, and a SIMD array of 1536 bit-serial processors with corresponding memory. The SIMD processor array can deliver more than 100 GOPS sustained and the onchip pixel-analyzing rate can be as high as 4 Gpixels/s. The sensor is intended for high-speed multisense imaging where, e.g., color, greyscale, internal material
Hyperoxia inhibits several critical aspects of vascular development (2007)

Normal human retinal vascular development uses angiogenesis and vasculogenesis, both of which are interrupted in the vaso-obliteration phase of retinopathy of prematurity (ROP). Canine oxygen-induced retinopathy (OIR) closely resembles human ROP. Canine retinal endothelial cells (ECs) and angioblasts were used to model OIR and characterize the effects of hyperoxia on angiogenesis and vasculogenesis. Cell cycle analysis showed that hyperoxia reduced the number of G1 phase cells and showed increased arrest in S phase for both cell types. Migration of ECs was significantly inhibited in hyperoxia (P < 0.01). Hyperoxia disrupted the cytoskeleton of angioblasts but not ECs after 2 days. Differentiation of angioblasts into ECs (determined by acetylated low-density lipoprotein uptake) was evaluated after basic fibroblast growth factor treatment. Differentiation of angioblasts into pericytes was determined by smooth muscle actin expression after treatment with platelet-derived growth factor. Differentiation into ECs was significantly inhibited by hyperoxia (P < 0.0001). The percentage of CXCR4(+) cells (a marker for retinal vascular precursors) increased in both treatment groups after hyperoxia. These data show novel mechanisms of hyperoxia-induced disruption of vascular development.
Oxidation of M4Si4 (M = Na, K) to Clathrates by HCl or H2O (2007)

The synthesis of clathrate-II germanium □24Ge136 in an ionic liquid was recently discovered.1 The key step in this process, the controlled oxidation of reactive precursor phases by a protic acid, was successfully applied to silicides M4Si4 (M = Na, K). Through this method, clathrate-I compounds of composition M8-xSi46 were obtained as crystalline products. The synthetic method demonstrates a mild oxidative route to a large class of metastable intermetallic compounds.
Amines Made Easily:  A Highly Selective Hydroaminomethylation of Olefins (2003)

A highly chemo- and regioselective hydroaminomethylation of simple as well as functionalized alpha-olefins using a cationic rhodium precatalyst together with Xantphos as ligand is reported. Studies of the influence of ligands and reaction conditions led to an unprecedented selective hydroaminomethylation procedure. The novel procedure constitutes an economically attractive and environmentally favorable synthesis of secondary and tertiary aliphatic amines.
OCT image guidance for gastrointestinal endoscopic cryobiopsy (2022)

Endoscopic biopsies play a vital role in the diagnosis of many diseases of the gastrointestinal (GI) tract. The standard means of biopsy capture using forceps presents challenges in obtaining adequate tissue samples, especially for unsedated transnasal endoscopy (uTNE). Cryobiopsy is an emerging minimally-invasive alternative where the distal tip of a dual-lumen uTNE probe is cooled momentarily, freezing and adhering the tissue in contact, which is collected for histology. OCT image guidance during cryobiopsy can enable pre-biopsy lesion examination; however, dimensional constraints make this challenging. Here, we demonstrate a microscale 3D-printed device capable of minimally-invasive side-viewing OCT image-guided cryobiopsy though uTNE scopes.
Responsive Copolymers for Enhanced Petroleum Recovery (2001)

The objectives of this work was to: synthesize responsive copolymer systems; characterize molecular structure and solution behavior; measure rheological properties of aqueous fluids in fixed geometry flow profiles; and to tailor final polymer compositions for in situ rheology control under simulated conditions. This report focuses on the synthesis and characterization of novel stimuli responsive copolymers, the investigation of dilute polymer solutions in extensional flow and the design of a rheometer capable of measuring very dilute aqueous polymer solutions at low torque.
Nepenthes section Insignes in Indonesia, with two new species (2018)

A review of new data relating to Nepenthes insignis in Indonesia indicates that three taxa in section Insignes, not one, are present in New Guinea. One of these, endemic to the limestone of the island of Biak, is formally named as Nepenthes biak and assessed as Critically Endangered; the other, from limestone of the Raja Ampat islands is provisionally distinguished as Nepenthes sp. Raja Ampat, since only images are available.
A Throughput Fast Measurement Method for Two-Antenna Equipped Wireless MIMO Terminals (2023)

According to the third Generation Partnership Project specification, a period of 8–12.8 h is required to evaluate the multiple-input–multiple-output (MIMO) performance of a wireless terminal for a single frequency point and channel model combination. The following article proposes a semi-simulation, semi-measurement-based MIMO throughput modeling scheme which can reduce the 8–12.8-h measurement time to 40–60 min, corresponding to more than a ten times improvement of the test efficiency, without loss of the test accuracy.
They Filched Our Program! How to Turn That into a Good Thing (2006)

The Butler University Honors Program, like many other honors programs and colleges, is often the generator of “good ideas” on campus. We are considered an experimental classroom environment for piloting new courses, programming ideas, and/or introducing potential new areas of study. Both faculty and students recognize this characteristic of the program, and we are pleased to serve as a sort of laboratory for other campus initiatives. However, several key pieces of our Honors Program were recently folded into other aspects of our own university. While we know that imitation is the highest form of flattery, maintaining a distinct honors program becomes challenging when many of our most innovative and successful ideas are filched by other areas of the university all at once. In this article we outline the background of our Honors Program, describe the ideas that were filched, and state our intentions for dealing with this issue in the future.
Acylhomoserine Lactone Synthase Activity of the Vibrio fischeri AinS Protein (1999)

Acylhomoserine lactones, which serve as quorum-sensing signals in gram-negative bacteria, are produced by members of the LuxI family of synthases. LuxI is a Vibrio fischeri enzyme that catalyzes the synthesis of N-(3-oxohexanoyl)-L-homoserine lactone from an acyl-acyl carrier protein and S-adenosylmethionine. Another V. fischeri gene, ainS, directs the synthesis of N-octanoylhomoserine lactone. The AinS protein shows no significant sequence similarity with LuxI family members, but it does show sequence similarity with the Vibrio harveyi LuxM protein. The luxM gene is required for the synthesis of N-(3-hydroxybutyryl)-L-homoserine lactone. To gain insights about whether AinS and LuxM represent a second family of acylhomoserine lactone synthases, we have purified AinS as a maltose-binding protein (MBP) fusion protein. The purified MBP-AinS fusion protein catalyzed the synthesis of N-octanoylhomoserine lactone from S-adenosylmethionine and either octanoyl-acyl carrier protein or, to a lesser extent, octanoyl coenzyme A. With the exception that octanoyl coenzyme A served as an acyl substrate for the MBP-AinS fusion protein, the substrates for and reaction kinetics of the MBP-AinS fusion protein were similar to those of the several LuxI family members previously studied. We conclude that AinS is an acylhomoserine lactone synthase and that it represents a second family of such enzymes.
Ciência Cidadã Baseada em Big Data Aplicada ao Planejamento Urbano (2016)

Neste artigo são apresentados um modelo e uma arquitetura para construção e estruturação de ambientes que necessitam realizar, eficientemente, armazenamento, busca e análise de grandes volumes de dados. Para a implementação do modelo foi utilizado o projeto ParticipACT Brasil. Este projeto visa implantar na cidade de Florianópolis o processo de ciência cidadã para obter informações relevantes que auxiliem os gestores a resolverem problemas urbanos. Pode-se observar, então que a implementação do modelo facilitou a estruturação do ambiente, e ajudou na escolha de ferramentas especializadas na manipulação de big data.
Time scale dependence of diffusion in porous material: Dynamic light scattering and computer simulation (1990)

Diffusion of polymer chains in liquid-filled pores of controlled pore size silica glasses was studied experimentally by using dynamic light scattering (DLS), and by a computer simulation based on a hydrodynamic theory of hard spheres in cylindrical pores. Dynamic light scattering at fixed scattering wave vector revealed faster apparent diffusion at short times (corresponding to diffusion within a single pore) followed by a slower relaxation which we attribute to macroscopic diffusion over distances large enough to average over the microscopic nonuniformities of the glass-pore matrix. The measured time at which the behavior crosses over from faster to slower diffusion was found to be independent of the light scattering wave vector, and is roughly equal to the time required for a polymer molecule to diffuse a distance comparable to the pore radius. At small ratio of polymer to pore radius, the crossover time was found to be proportional to the polymer radius, both in DLS measurements and in the computer simulation.
A Behavioral-Based Fingerprint Liveness and Willingness Detection System (2022)

Fingerprints have been used for decades to verify the identity of an individual for various security reasons. Attackers have developed many approaches to deceive a fingerprint verification system, ranging from the sensor level, where gummy fingers are created, to gaining access to the decision-maker level, where the decision is made based on low matching criteria. Even though fingerprint sensor-level countermeasures have developed advanced metrics to detect any attempt to dupe the system, attackers still manage to outwit a fingerprint verification system. In this paper, we present the Micro-behavioral Fingerprint Analysis System (MFAS), a system that records the micro-behavior of the user’s fingertips over time as they are placing their fingerprint on the sensor. The system captures the stream of ridges as they are formed while placed on a sensor to combat the attacks that deceive the sensor. An experiment on 24 people was conducted, wherein the fingerprints and the behavior of the fingertip as it is placed were collected. Subsequently, a gummy finger was created to try to fool the system. Further, a legitimate user was chosen to participate in an experiment that mimicked an attempt to use their fingertip unwillingly to detect coerced fingerprint placement. After applying the micro-behavior, the system reported 100% true positives and 0% false-negatives when providing legitimate vs. gummy-based fingerprints to authenticate a malicious user. The system also reported a 100% accuracy in differentiating between a voluntary and a coerced fingerprint placement. The results improve the fingerprint robustness against attacks on a fingerprint sensor by factoring in micro-behavior, thus helping to overcome fake and coerced fingerprint attacks.
Overview of the issues related to the use of Radioisotope Power Systems in European space missions (2019)

Space nuclear power is the most viable energy source for some space missions, such as the exploration of outer planets or the exploration of a planetary surface with long day/night cycles. Thanks to high energy densities, certain isotopes can generate considerable amounts of heat for long time periods, independently of insolation levels; this heat can be converted into electrical power, or used to keep suitable temperatures inside the spacecraft. However, the presence of radioactive material implies new requirements, to properly manage all the aspects related to safety. A common European safety framework is required for Europe and ESA to independently manage radioisotope power systems: a significant amount of programmatic effort in many domains and by different entities will therefore be required, but the long and wide-ranging experience of other countries in dealing with space nuclear power systems could be an appropriate starting point.
The use of videoconferencing with patients with psychosis: a review of the literature (2011)

Videoconferencing has become an increasingly viable tool in psychiatry, with a growing body of literature on its use with a range of patient populations. A number of factors make it particularly well suited for patients with psychosis. For example, patients living in remote or underserved areas can be seen by a specialist without need for travel. However, the hallmark symptoms of psychotic disorders might lead one to question the feasibility of videoconferencing with these patients. For example, does videoconferencing exacerbate delusions, such as paranoia or delusions of reference? Are acutely psychotic patients willing to be interviewed remotely by videoconferencing? To address these and other issues, we conducted an extensive review of Medline, PsychINFO, and the Telemedicine Information Exchange databases for literature on videoconferencing and psychosis. Findings generally indicated that assessment and treatment via videoconferencing is equivalent to in person and is tolerated and well accepted. There is little evidence that patients with psychosis have difficulty with videoconferencing or experience any exacerbation of symptoms; in fact, there is some evidence to suggest that the distance afforded can be a positive factor. The results of two large clinical trials support the reliability and effectiveness of centralized remote assessment of patients with schizophrenia.
Characterizing Ge28Sb12Se60 in the Near- and Mid-Infrared (2015)

This thesis examines applications of chalcogenide glasses and their potential for use in the mid-infrared region and discusses methods by which the bulk loss absorption of these materials can be measured in this regime. The bulk loss was measured for Ge28Sb12Se60 as well as reference sample Ge33As12Se55 in both the near- and mid-infrared, at specific wavelengths of 1.534 Î¼m and 3.677 Î¼m. The bulk loss for the Ge28Sb12Se60 sample was measured to be (0.07 Â± 0.2) cm-1 in the near-infrared and (0.06 Â± 0.18) cm-1 in the mid-infrared. This value was measured for the Ge33As12Se55 reference sample to be (0.07 Â± 0.2) cm-1 in the near-infrared and (0.03 Â± 0.16) cm-1 in the mid-infrared. The expected values of bulk loss, calculated using values of extinction coefficients listed on the Refractive Index Database, were 0.059 cm-1 at 1.534 Î¼m and 0.048 cm-1 at 3.677 Î¼m for the Ge28Sb12Se60 sample and 0.036 cm-1 at 1.534 Î¼m and 0.028 cm-1 at 3.677 Î¼m for the Ge33As12Se55 reference sample. The approximate agreement with expected values, suggests that these measurements provide good order-of-magnitude estimates of the bulk loss values of the two materials, limited by the large error on the approximations. Ultimately, this suggests that both Ge28Sb12Se60 and Ge33As12Se55 can be considered transparent in the infrared.
Atrial sources of reactive oxygen species vary with the duration and substrate of atrial fibrillation: implications for the antiarrhythmic effect of statins (2011)

Background—An altered nitric oxide–redox balance has been implicated in the pathogenesis of atrial fibrillation (AF). Statins inhibit NOX2-NADPH oxidases and prevent postoperative AF but are less effective in AF secondary prevention; the mechanisms underlying these findings are poorly understood. Methods and Results—By using goat models of pacing-induced AF or of atrial structural remodeling secondary to atrioventricular block and right atrial samples from 130 patients undergoing cardiac surgery, we found that the mechanisms responsible for the NO-redox imbalance differ between atria and with the duration and substrate of AF. Rac1 and NADPH oxidase activity and the protein level of NOX2 and p22phox were significantly increased in the left atrium of goats after 2 weeks of AF and in patients who developed postoperative AF in the absence of differences in leukocytes infiltration. Conversely, in the presence of longstanding AF or atrioventricular block, uncoupled nitric oxide synthase activity (secondary to r...
Process Options in Hepatitis B Surface Antigen Extraction from Transgenic Potato (2000)

The process conditions for recombinant hepatitis B surface antigen (HBsAg) extraction from transgenic potato were examined. The effects of temperature, the reducing agent beta-mercaptoethanol (BME), and proteinase inhibitors on the level of antigenic activity of recovered HBsAg were determined. Sedimentation profiles were performed to characterize HBsAg assembly into virus-like particles. Increasing the temperature of the sample for about 1 min increased the measured HBsAg antigenic activity. The optimum temperature was around 50 degrees C. A 3-fold enhancement of the antigenic activity was obtained in extract from transgenic potato expressing HBsAg, when monoclonal antibodies were used to assay for HBsAg. When antigenic activity was determined by polyclonal antibodies, no enhancement in the antigenic activity was obtained. Temperature may affect the conformation of the a epitope to which the monoclonal antibodies bind or alter the fluidity of surface lipid regions. BME increased the antigenic activity of HBsAg up to 4-fold when monoclonal antibodies directed against the a determinant were used, but there was no increase with polyclonal antibodies. This observation suggests that BME affects the structure or presentation of the a epitope. In the presence of BME and leupeptin, a proteinase inhibitor, higher antigenic activity was obtained. Leupeptin might protect the antigen, which might become more susceptible to proteolytic degradation after reduction, as a result of stimulation of sulfhydryl proteases. Although both temperature and BME increased the antigenic activity of HBsAg individually, when combined their interaction was antagonistic, resulting in reduced antigenic activity. Different proteinase inhibitors, including leupeptin, aprotinin, E-64, pefabloc, and pepstatin, had no significant effect on HBsAg from potato extract in a 2 h period in the absence of BME. The sedimentation profile of potato-produced HBsAg was determined in 5-30% sucrose gradients. Yeast-derived recombinant HBsAg was used as a positive control. The HBsAg from transgenic potato showed sedimentation and density properties that are very similar to the yeast-produced antigen, indicating assembly into virus-like particles. BME treatment did not change the sedimentation profile.
Southern African Wave Model Sensitivities and Accuracies (2020)

Numerous studies have identified the complexities of the wave climatology around the South African coast, but limited studies have investigated these complex dynamics in the available literature. Several freely available parameterized wave boundary conditions are produced around southern Africa. However, none of these are fully spectral outputs from global or larger regional spectral wave models. This constraint results in local engineering and scientific organizations, reconstructing their own spectral boundary conditions. For coastal models, this is a reasonable assumption, assuming that the single parameterization is accurate and a representation of a non-multimodal sea state. The South African Weather Service (SAWS) Marine unit recently launched their coupled, operational wave and storm surge forecasting model. The aim of the SAWS Wave and Storm Surge (SWaSS) platform was to provide accurate, high-resolution coastal forecasts for the entire South African coastline. The present investigation thus presents the validation of the spectral wave component of the coupled system, developed in Delft3D. Various wave boundary reconstructions are investigated together with the two most used and well-known whitecapping formulations. Validation is performed with both in situ wave-rider buoy data (at nine locations along the coastline) and regional remotely sensed, along track, altimetry data. Full model performance statistics are provided, and the accuracy of the model is discussed.