gebhart/patrepeval huggingface dataset:
<title>Patent approved: a hybrid CRT design for advanced TV and other large-format digital displays</title> (1998)

A patent has been awarded for a new CRT design that eliminates the internal shadow mask, and promises a bright, rugged, high-resolution/large-format, multiscan/multi-sync display with potentially low manufacturing costs. The design incorporates a light-valve within the CRT. Modulation of the electron gun and the function of the shadow mask are replaced by two chemical reactions typical of phosphors: decays stimulation and quenching. These reactions are controlled through illumination of the phosphors by non- visible light projected through the light-valve. The image is generated in traditional raster form, but with a single, non-modulated electron gun; control of each pixel is made through modulation of the light-valve. The design decrease manufacturing alignment requirements and eliminates the need to focus the electron gun. Advantages include: high-G resistance due to elimination of the shadow mask; brighter displays because the electron beam is not occluded or absorbed by the shadow mask; elimination of decay rate as a parameter in phosphor choice and frame rate; and digital interfacing to image sources. Applications include: large- format displays without the physical constraints of the shadow mask and by elimination of distortion control requirements of the electron beam at the image edges; variable frame rates by modulating the decay rate of the phosphors through quenching; and stereoscopic displays without crosstalk through control of left-right phosphor decay rates.
Subsequential Alterations of Telomeric DNA Length Correlate with Cytogenetic Response in Chronic Myeloid Leukemia Treated with Interferon alpha (1999)

Telomeres consist of simple tandem hexametric (TTAGGG) repeats and progressively shorten with cell replication. To determine a relationship between telomeric erosion and response to treatment, we measured telomere length following treatment in patients with chronic myeloid leukemia (CML) in the chronic phase. We used 70 samples of bone marrow mononuclear cells obtained from 26 patients with CML in the chronic phase subsequently. Telomere length was determined by a Southern hybridization of HinfI-digested DNA using a (TTAGGG)(4) probe, and the terminal restriction fragment (TRF) length was measured. Telomerase activity was also measured in 14 CML patients at the time of diagnosis using a telomeric repeat amplification protocol (TRAP) assay. Of the 26 patients with CML at the time of diagnosis, 14 had normal TRF lengths and the remaining 12 had shortened TRFs compared to those of age-matched normal individuals. In a group of CML patients treated with interferon alpha (IFNalpha), 80% of those who showed normal TRFs obtained cytogenetic responses. Approximately 50% of patients with shortened TRFs and treated with IFNalpha showed normalization of TRFs after IFNalpha treatment and all of them were cytogenetic responders. None of the CML patients with shortened TRFs before and after IFNalpha treatment achieved major cytogenetic response and they had high levels of telomerase activity. In the group of CML patients treated with hydroxyurea alone, although some patients showed normalization of TRF lengths after treatment, none of them showed major cytogenetic response. Telomere length before treatment may be related to CML disease severity. Cytogenetic response could be expected in CML patients with normal TRF lengths and treated with IFNalpha. Thus, measurement of telomere length after treatment might provide important information in managing CML patients.
Intensity-based signal separation algorithm for accurate quantification of clustered \ncentrosomes in tissue sections (2006)

Centrosomes are small organelles that organize the mitotic spindle during cell division and are also involved in cell shape and polarity. Within epithelial tumors, such as breast cancer, and some hematological tumors, centrosome abnormalities (CA) are common, occur early in disease etiology, and correlate with chromosomal instability and disease stage. In situ quantification of CA by optical microscopy is hampered by overlap and clustering of these organelles, which appear as focal structures. CA has been frequently associated with Tp53 status in premalignant lesions and tumors. Here we describe an approach to accurately quantify centrosomes in tissue sections and tumors. Considering proliferation and baseline amplification rate the resulting population based ratio of centrosomes per nucleus allow the approximation of the proportion of cells with CA. Using this technique we show that 20-30 percent of cells have amplified centrosomes in Tp53 null mammary tumors. Combining fluorescence detection, deconvolution microscopy and a mathematical algorithm applied to a maximum intensity projection we show that this approach is superior to traditional investigator based visual analysis or threshold-based techniques.
A Review of the Methodologies Used in the Derivation of Formulas for Parametric Survival Functions with Illustrative Numerical Examples (2019)

In this review paper formulas for survival functions are derived that take into account risks of deaths in early life including infancy, mid life, a random component of deaths due to accidents and deaths in older ages. The basic ideas used in the derivation of survival function for each of the components just mentioned are risk functions. Given a formula for a risk function, it is possible to derive a formula for the corresponding survival function. By using the theory of competing risks, a formula for survival function that takes into account the risks of deaths in various stages of life expressed as a product of survival functions for the risks of deaths under consideration. For many applications information on the numerical values of parameters in survival functions is not available. Consequently, rationales are developed for assigning plausible values to parameters that take into account personal ideas of an investigator may have for each stage of life. For every assignment of parameter values in the paper, a numerical version of survival functions are plotted in graphs so that an assessment of the plausibility of the chosen parameter values may be made. Also included in the paper is an application of survival functions in an experiment to make an assessment as to whether a small population of chimpanzees, or some other endangered species of animals, will have descendants that make up a surviving population 200 years into the future.
Ultrasonic sound speed microscope for biological tissue characterization driven by nanosecond pulse (2003)

Ultrasonic microscopy is expected as a powerful tool for biological tissue characterization. Its clinical application to histopathological examination during surgery is being considered. The data are also important to assess the origin of clinical echographic imaging. In clinical point of view, the microscopic observation should be as quick as possible to carry out the surgery in a short period.
Re: The safety of oral calcium formate (2003)

A Short Communication was published in the October 2002 issue of the New Zealand Veterinary Journal entitled An investigation of the safety of oral calcium formate in dairy cows using clinical, biochemical and histopathological parameters (McIntyre and Weston 2002). It appeared to be comparing results directly with those of a prior communication (Scott and Van Wijk 2000). The following should be considered when comparing the two papers. Haptoglobins were propounded by McIntyre and Weston as definitive indicators of acute inflammation, yet current literature does not give consistent viewpoints as to their value. The authors cited instances where the haptoglobin concentration was measured in cases of infective disease. However, Skinner et al (1991) believed that haptoglobin concentrations increase as a result of the infection rather than the trauma. To further complicate matters Alsemgeest et al (1994) found that haptoglobin concentrations were elevated in cattle with chronic rather than acute conditions whereas Horadagoda et al (1999) believed the concentrations of acute-phase proteins were higher in acute inflammation. However, they found serum amyloid A was more reliable as an indicator of acute, rather than chronic, inflammation than was haptoglobin. Therefore, histopathology would appear to give much more conclusive evidence of mucosal inflammation than the determination of haptoglobin...
Impact de la température du convertisseur sur les perturbations CEM émises vers un réseau HVDC (2016)

National audience
Novel Non-Intrusive Trans-Dermal Remote Wireless Micro-Fluidic Monitoring System Applied to Continuous Glucose and Lactate Assays for Casualty Care and Combat Readiness Assessment (2004)

We present results on both the bio-medical engineering development of a non-intrusive, wireless, microfluidic physiological monitoring and remote transmission field system, and its performance measuring continuous glucose and lactate concentrations in the interstitial fluid of rats subjected both to glucose-stress tests, and to hemorrhagic shock. These directly address the two symposium topics of Monitoring of physiological parameters and measurement of vital signs in the field and of Medical surveillance in a command environment, remote monitoring and guidance of field personnel .
Role of Ag sheath on the Formation of 2223 Phase of Bi-based Superconducting Oxide Tapes. (1997)

The role of Ag sheath on the formation of a 2223 phase in Ag-sheathed Bi-Pb-Sr-Ca-Cu oxide tapes was investigated. It was found that the Ag sheath promoted the formation of the 2223 phase through the extension of the temperature range between its partial melting and decomposition as well as through the ease of the control of the atomosphere in the Ag sheath. Furthermore, the Ag sheath was recognized to act as an effective substrate for the formation of the well-developed texture structure.
Infection of specific strains of Streptococcus mutans, oral bacteria, confers a risk of ulcerative colitis (2012)

Although oral bacteria-associated systemic diseases have been reported, association between Streptococcus mutans, pathogen of dental caries, and ulcerative colitis (UC) has not been reported. We investigated the effect of various S. mutans strains on dextran sodium sulfate (DSS)-induced mouse colitis. Administration of TW295, the specific strain of S. mutans, caused aggravation of colitis; the standard strain, MT8148 did not. Localization of TW295 in hepatocytes in liver was observed. Increased expression of interferon-γ in liver was also noted, indicating that the liver is target organ for the specific strain of S. mutans-mediated aggravation of colitis. The detection frequency of the specific strains in UC patients was significantly higher than in healthy subjects. Administration of the specific strains of S. mutans isolated from patients caused aggravation of colitis. Infection with highly-virulent specific types of S. mutans might be a potential risk factor in the aggravation of UC.
10μm Pitch Bumping of Singulated Die Using a Temporary Metal-Embedded Chip Assembly Process (2022)

This paper presents a novel process for fine-pitch bumping of singulated multi-project wafer (MPW) die. The MPW chips are integrated onto a silicon interposer using a variation of HRL’s Metal Embedded Chip Assembly (MECA) technology, wherein thin electroplated copper is used as the temporary embedding material. Chip placement misalignment is assessed and corrected for during subsequent lithography steps, allowing us to achieve die bumping down to 10μm pitch. The chips are finally released from the interposer and are ready for flip-chip packaging. In this effort, 1mm x1mm 10μm pitch I/O test die were fabricated. The chips were bumped using different fabrication processes (liftoff, plating, and metal etching) to demonstrate the versatility of the Temporary MECA (T-MECA) approach. The bumped die were released from the reconstructed wafer and bonded onto a test interposer using Au-Au thermo-compression. A pad-to-pad resistance of 90mΩ and bonding yield of >95% were extracted from DC measurements of daisy chain structures.
Non-linear simulation of the aspherical deformation of piezo-glass membrane lenses including hysteresis and fabrication effects (2018)

In this paper we present and verify the non-linear simulation of an aspherical adaptive lens based on a piezo-glass sandwich membrane with combined bending and buckling actuation. To predict the full non-linear piezoelectric behavior, we measured the non-linear charge coefficient, hysteresis and creep effects of the piezo material and inserted them into the FEM model using a virtual electric field. We further included and discussed the fabrication parameters - glue layers and thermal stress - and their variations. To verify our simulations, we fabricated and measured a set of lenses with different geometries, where we found good agreement and show that their qualitative behavior is also well described by a simple analytical model. We finally discuss the effects of the geometry on the electric response and find, e.g., an increased focal power range from $\pm 4.5$ to $\pm 9\, \mathrm{m}^{-1}$ when changing the aperture from $14$ to $10\, \mathrm{mm}$.
ATP‐ADP compartmentation in storage pool deficient platelets: correlation between granule‐bound ADP and the bleeding time (1983)

Platelets contain two major compartments of ATP and ADP, the cytosol and the dense granules. We separated the two compartments by controlled digitonin-induced cell lysis and measured both fractions directly in the platelets of 16 patients with storage pool deficiency. The total contents of ATP and ADP in the platelets of these patients was significantly lower than in normal controls. This was primarily caused by decreased amounts of ATP and ADP in the granule compartment, but also cytosolic ADP was low in these patients. In contrast, cytosolic ATP was not significantly decreased. The lower the amount of granule-bound ATP and ADP, the longer was the bleeding time in these patients. The best correlation was found with granule ADP. These data may indicate that ADP stored in platelet dense granules plays a role in the arrest of bleeding.
Chemistry of Boranes. XVIII. Oxidation of B10H10-2 and Its Derivatives (1964)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemistry of Boranes. XVIII. Oxidation of B10H10-2 and Its DerivativesB. L. Chamberland and E. L. MuettertiesCite this: Inorg. Chem. 1964, 3, 10, 1450–1456Publication Date (Print):October 1, 1964Publication History Published online1 May 2002Published inissue 1 October 1964https://pubs.acs.org/doi/10.1021/ic50020a025https://doi.org/10.1021/ic50020a025research-articleACS PublicationsRequest reuse permissionsArticle Views296Altmetric-Citations58LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
2‐Methyl‐1,3‐Cyclopentanedione (2003)

Abstract 2‐Methyl‐1,3‐cyclopentanedione product: 2‐methyl‐1,3‐cyclopentanedione
Preparation of some Important Medicinal Compounds. Thiosemicarbazones, Thiadiazolines, 4-Thiazolidinones and 5-Aryheiline Derivatives as Antibacterial and Tuberculostatic Agents (1987)

University Department of Chemistry, Bhavnagar University, Bhavnagar-364 002 <em>Manuscript received 6 August 1984, accepted 20 July 1985</em> Thiosemicarbazides (1) have been prepared by the reaction of initial amine, ammonia and carbon disulphide with ethanol (95%) and sodium chloroacetate, followed by addition of hydrazine hydrate. Benzaldehyde 4-(2-ethoxyphenyl)-3-thiosemicarbazones (2) have been prepared by the condensation of thiosemicarbazide (1) and different aldehydes in boiling ethanol (95%) Thiosemicarbazones (2) treated with NaOH (5%) and potassium ferricyanide solution produced thiadiazolines (3). The conden­sation of thiosemicarbazones with mercaptoacetic acid gave 4-thiazolidi­nones, which further reacted with different aldehydes in presence of sodium ethoxide to produce 5-arylidine derivatives.
Effet d'un traitement à base de GH exogène sur la croissance folliculaire de la jument, en fonction de son état nutritionnel (2011)

absent
OXIDATION OF METALS CONTAINING DISPERSED OXIDE PARTICLES. (1968)

Human umbilical cord mesenchymal stem cell-derived small extracellular vesicle (hUC-MSCs-sEVs) therapy has shown promising results to treat diabetes mellitus in preclinical studies. However, the dosage of MSCs-sEVs in animal studies, up to 10 mg/kg, was considered high and may be impractical for future clinical application. This study aims to investigate the efficacy of low-dose hUC-MSCs-sEVs treatment on human skeletal muscle cells (HSkMCs) and type 2 diabetes mellitus (T2DM) rats. Treatment with hUC-MSCs-sEVs up to 100 μg/mL for 48 h showed no significant cytotoxicity. Interestingly, 20 μg/mL of hUC-MSCs-sEVs-treated HSkMCs increased glucose uptake by 80-90% compared to untreated cells. The hUC-MSCs-sEVs treatment at 1 mg/kg improved glucose tolerance in T2DM rats and showed a protective effect on complete blood count. Moreover, an improvement in serum HbA1c was observed in diabetic rats treated with 0.5 and 1 mg/kg of hUC-MSCs-sEVs, and hUC-MSCs. The biochemical tests of hUC-MSCs-sEVs treatment groups showed no significant creatinine changes, elevated alanine aminotransferase (ALT) and alkaline phosphatase (ALP) levels compared to the normal group. Histological analysis revealed that hUC-MSCs-sEVs relieved the structural damage to the pancreas, kidney and liver. The findings suggest that hUC-MSCs-sEVs could ameliorate insulin resistance and exert protective effects on T2DM rats. Therefore, hUC-MSCs-sEVs could serve as a potential therapy for diabetes mellitus.
Phagocytosis and antigen presentation in dendritic cells (2007)

Like macrophages and neutrophils, dendritic cells (DCs) are considered professional phagocytes. Even if the three cell types phagocytose parasites, bacteria, cell debris, or even intact cells very efficiently, the functional outcomes of the phagocytic event are quite different. Macrophages and neutrophils scavenge and destroy phagocytosed particles, a critical step in innate immunity. DCs, in contrast, have developed means to 'preserve' useful information from the ingested particles that serve to initiate adaptive immune responses. Thus, both phagosomal degradation and acidification are much lower in DCs than in macrophages or neutrophils. Reduced degradation results in the conservation of antigenic peptides and in their increased presentation on major histocompatibility complex class I and II molecules. In this article, we review the mechanisms that control this delicate equilibrium between phagosomal degradation/cytotoxicity and antigen presentation in the different families of phagocytes.
The chemistry of the brain (2009)

Item consists of a digitized copy of an audio recording of a Vancouver Institute lecture given by Richard Weinshilboum on March 22, 1980, 2009. Original audio recording available in the University Archives (UBC AT 920).
Electrodeposition of kesterite thin films for photovoltaic applications: Quo vadis? (2014)

This paper aims at providing an updated overview of the main achievements in the development of solar cells based on Cu2ZnSn(S,Se)4 (CZTS(Se)) kesterite absorbers obtained by electrodeposition. Although undoubtedly challenging, the ultimate goal is to learn from the past works and build a solid framework for future advances in this field. What is the reason for the lower efficiency of electrodeposited CZTS(Se)-based devices (8%) compared to the world record efficiency achieved with a hydrazine-based solution approach (12.6%)? Can this gap be filled, or there are intrinsic limitations for this achievement? The review is divided into the three main electrodeposition approaches: sequential elemental layer, alloy co-deposition, and chalcogenide co-deposition. It is argued that considerable technical challenges must be overcome for the latter approach to be successfully applied. Plot of the record power conversion efficiencies of kesterite sulfide-based solar cells obtained by electrodeposition (hollow dots), and world record efficiency of CZTS(Se)-based devices (full dots). The dashed line shows the 15% minimum efficiency threshold considered relevant for potential industrial application.
Improved and General Manganese‐Catalyzed N‐Methylation of Aromatic Amines Using Methanol (2017)

A novel lutidine-based manganese PNP-pincer complex has been synthesized for the selective N-methylation of aromatic amines with methanol. Using borrowing hydrogen methodology, a selection of differently functionalized aniline derivatives is selectively methylated in good yields.
Endocytosis of Secreted Carboxyl Ester Lipase in a Syndrome of Diabetes and Pancreatic Exocrine Dysfunction (2014)

Maturity-onset diabetes of the young, type 8 (MODY8) is characterized by a syndrome of autosomal dominantly inherited diabetes and exocrine pancreatic dysfunction. It is caused by deletion mutations in the last exon of the carboxyl ester lipase (CEL) gene, resulting in a CEL protein with increased tendency to aggregate. In this study we investigated the intracellular distribution of the wild type (WT) and mutant (MUT) CEL proteins in cellular models. We found that both CEL-WT and CEL-MUT were secreted via the endoplasmic reticulum and Golgi compartments. However, their subcellular distributions differed, as only CEL-MUT was observed as an aggregate at the cell surface and inside large cytoplasmic vacuoles. Many of the vacuoles were identified as components of the endosomal system, and after its secretion, the mutant CEL protein was re-internalized, transported to the lysosomes, and degraded. Internalization of CEL-MUT also led to reduced viability of pancreatic acinar and beta cells. These findings may have implications for the understanding of how the acinar-specific CEL-MUT protein causes both exocrine and endocrine pancreatic disease.