gebhart/patrepeval huggingface dataset:
Complexes of phosphineâ€“phenolate ligands with the [Reî€O]3+ and [Re(HNNC5H4N)(NNC5H4N)]2+ cores (2001)

Complexes incorporating the [ReO]3+ core have been synthesised with ligands containing the new methyl substituted phosphine–phenolate PO and PO2 donor sets, (2-hydroxy-5-methylphenyl)diphenylphosphine (H(MePO)) and bis(2-hydroxy-5-methylphenyl)phenylphosphine (H2(Me2PO2)). The analogous tert-butyl ligands, (5-tert-butyl-2-hydroxyphenyl)diphenylphosphine (H(t-BuPO)) and bis(5-tert-butyl-2-hydroxyphenyl)phenylphosphine (H2(t-Bu2PO2)), were also prepared. Reaction of either mer-[ReOCl3(PPh3)2] or [NH4][ReO4] in CH3OH with H(MePO) led to formation of [ReOCl(MePO)2] (1) in good yield. Reaction of [NH4][ReO4] with H2(Me2PO2) in CH3OH afforded [ReO(Me2PO2)(H(Me2PO2))] (2), also in good yield. X-Ray crystallographic analyses of 1 and 2 demonstrated that both complexes are neutral and octahedral, and contain the oxo moiety. Two complexes have been structurally characterised from the reaction of (o-hydroxyphenyl)diphenylphosphine (HPO) with [Re(Hhypy)(hypyH)Cl3]: [Re(Hhypy)(hypy)(PO)(HPO)]Cl (3) and [ReCl(Hypy)(hypy)(PO)] (4) (hypy = NNC5H4N, Hhypy = HNNC5H4N, hypyH = NNC5H4NH). X-Ray crystallography demonstrated that both are Re(III) complexes; 3 is monocationic with an N3OP2 coordination sphere while 4 is neutral with a ClN3OP coordination sphere. [Re(Hhypy)(hypy)(HPO2)(H2PO2)]Cl (5) and [Re(Hhypy)(hypy)(H(Me2PO2))(H2(Me2PO2))]Cl (6) were synthesised by reaction of [Re(Hhypy)(hypyH)Cl3] in CH3OH with bis(o-hydroxyphenyl)phenylphosphine (H2PO2) and H2(Me2PO2) respectively. Compounds 5 and 6 were shown by 1H and 31P NMR spectroscopies to have the same N3OP2 coordination sphere as [Re(Hhypy)(hypy)(PO)(HPO)]Cl, with the addition of several uncoordinated, protonated phenolic donors.
Thermal Barrier Coatings for Gas-Turbine Engine Applications (2002)

Hundreds of different types of coatings are used to protect a variety of structural engineering materials from corrosion, wear, and erosion, and to provide lubrication and thermal insulation. Of all these, thermal barrier coatings (TBCs) have the most complex structure and must operate in the most demanding high-temperature environment of aircraft and industrial gas-turbine engines. TBCs, which comprise metal and ceramic multilayers, insulate turbine and combustor engine components from the hot gas stream, and improve the durability and energy efficiency of these engines. Improvements in TBCs will require a better understanding of the complex changes in their structure and properties that occur under operating conditions that lead to their failure. The structure, properties, and failure mechanisms of TBCs are herein reviewed, together with a discussion of current limitations and future opportunities.
Towards Control and Oversight of SARS‐CoV‐2 Diagnosis and Monitoring through Multiplexed Quantitative Electroanalytical Immune Response Biosensors (2022)

The development of versatile and sensitive biotools to quantify specific SARS-CoV-2 immunoglobulins in SARS-CoV-2 infected and non-infected individuals, built on the surface of magnetic microbeads functionalized with nucleocapsid (N) and in-house expressed recombinant spike (S) proteins is reported. Amperometric interrogation of captured N- and S-specific circulating total or individual immunoglobulin (Ig) isotypes (IgG, IgM, and IgA), subsequently labelled with HRP-conjugated secondary antibodies, was performed at disposable single or multiplexed (8×) screen-printed electrodes using the HQ/HRP/H<sub>2</sub>O<sub>2</sub> system. The obtained results using N and in-house expressed S ectodomains of five SARS-CoV-2 variants of concern (including the latest Delta and Omicron) allow identification of vulnerable populations from those with natural or acquired immunity, monitoring of infection, evaluation of vaccine efficiency, and even identification of the variant responsible for the infection.
Recurrent Bacterial Infections in Four Siblings with Neutropenia, Eosinophilia, Hyperimmunoglobulinemia A, and Defective Neutrophil Chemotaxis (1976)

Four siblings with recurrent bacterial infections, neutrophil chemotactic defect, neutropenia, and eosinophilia were studied. During periods of infection the peripheral neutrophil count increased to normal, while the eosinophilia disappeared. In addition, these children had high levels of serum IgA and poor antibody responses to tetanus and polio vaccinations. A defect in cell-mediated immunity was demonstrated by an absent or weak reactivity to various skin test antigens and by abnormal lymph node histology. Thus these siblings had an unusual combination of defective inflammatory response and immunologic abnormalities.
Appel à articles (2015)

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La grève dans les services publics (1993)

droit de greve s'exerce dans le cadre des lois qui le reglementent. Cette celebre formule issue du preambule de la constitution du 27 octobre 1946 a ete au centre d'un vif debat juridique qui, aujourd'hui encore, n'est pas clos. Apres avoir ete interdit pendant longtemps dans les services publics, fallait-il, en vertu de ce texte, reconnaitre le droit de greve aux agents de ces services ? et si oui, pouvaiton legalement et legitimement limiter la reconnaissance de ce droit a ces personnels ? par voie legislative, cela ne faisait aucun doute, le constituant de 1946 l'ayant expressement prevu. En revanche, par voie administrative, le probleme etait nettement plus delicat. Autant de questions extremement controversees auxquelles ces travaux tentent d'apporter des reponses a la lumiere des debats doctrinaux et de l'analyse des textes ainsi que des arrets des juges administratif, judiciaire et constitutionnel. Mais, au-dela des controverses suscitees par la reconnaissance et la reglementation du droit de greve, il est apparu necessaire, pour bien prendre conscience de la complexite du phenomene de la greve, de s'interesser egalement a l'exercice du droit de greve dans les services publics et, plus precisement, d'analyser, d'une part, les causes specifiques au secteur public du recours a la cessation concertee du travail et, d'autre part, les consequences de l'exercice du droit de greve.
Animal Models (2018)

This chapter focuses on tissue-specific gene targeting, the most widely used approach for analyzing gene function in skeletal tissues. The first widely used approach to study gene function in vivo was to produce transgenic mice that overexpress target genes. The most widely used technique for genetic manipulation is gene targeting in mouse embryonic stem (ES) cells. Several large-scale government-sponsored research programs provide access to targeting vectors, ES cells, or mice harboring a large number of mutated alleles. The generation of the knockout-first allele is flexible and can produce reporter knockouts, conditional knockouts, and null alleles following exposure to site-specific recombinases Cre and Flp. The chapter discusses the lineage controls and activity reporters. Transgenic reporter lines can also be used to monitor signaling pathway activity. The advancement of CRISPR/Cas9 technology has revolutionized genomic engineering. The technology can also be used to generate specific point mutations or conditional alleles.
Effect of vocal fold asymmetries on glottal flow (2016)

NA Laryngoscope, 126:2534-2538, 2016.
Functional genomics applied to the analysis of bovine muscle hypertrophy (2004)

International audience
In situ localization of short repetitive sequences on extendedDNA fibers of Silene latifolia (2001)

Fluorescence in situ hybridization (FISH) to chromosomes or DNA
fibers is a powerful technique to map genes and DNA sequences
to specific regions.In Silene latifolia, sequences 15 and 19
were studied in order to determine their copy numbers and
accurate positions relative to telomere using extended DNA
fiber-FISH (EDF-FISH).Fluorescent signals for sequence 15 were
consistently observed at the distal portion of almost all
chromosomes, while 19 signals were detected at the telomeric
region of roughly 6 to 10 chromosomes per diploid
genome.Results of EDF-FISH showed that sequences 15 and 19 are
adjacently located with telomere.
Properties of Structurally Restricted Antibody to Type VIII Pneumococcal Polysaccharide (1970)

Abstract Following three courses of immunization with type VIII pneumococci, the serum of one rabbit showed an unusually marked increase in electrophoretically-restricted γ globulin components consisting of anti-polysaccharide antibodies. Examination of the intact purified antibodies by isoelectric focusing and of the corresponding light chains by disc gel electrophoresis in urea disclosed a less complex banding pattern than was observed with antibody isolated from serum of a rabbit showing a diffuse increase in globulin components after immunization. The serum concentration of the electrophoretically-restricted γ globulin components increased and subsequently decreased after each course of immunization. Histologic examination following the third course showed evidence of an intense immune response; plasma cell tumors were not seen.
Process Analytical Chemistry (2007)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTProcess Analytical ChemistryJerome Workman,, Mel Koch, and Dave VeltkampView Author Information Molecular Spectroscopy and Microanalysis, Thermo Fisher Scientific Inc., 5225 Verona Road, Madison, Wisconsin 53711-4495, and Center for Process Analytical Chemistry (CPAC), University of Washington, Seattle, Washington 98195-1700 Cite this: Anal. Chem. 2007, 79, 12, 4345–4364Publication Date (Web):May 3, 2007Publication History Published online3 May 2007Published inissue 1 June 2007https://pubs.acs.org/doi/10.1021/ac070765qhttps://doi.org/10.1021/ac070765qreview-articleACS PublicationsCopyright © 2007 American Chemical SocietyRequest reuse permissionsArticle Views2081Altmetric-Citations42LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Chemometrics,Chromatography,Process control,Sensors,Separation science Get e-Alerts
Suspected protozoal myeloencephalitis in a two‐month‐old colt (2001)

A two-month-old Appaloosa colt developed neurological signs shortly after birth involving deficits affecting cranial nerves IV, VII, VIII, IX, X and XII, and possibly nerve VI. The most likely differential diagnoses were congenital anomalies, meningoencephalitides, trauma or nutritional causes. The foal was investigated by the analysis of cerebrospinal fluid (CSF), electromyelography (EMG), brain auditory evoked responses, magnetic resonance imaging (MRI), peripheral nerve biopsy, and Western blot analysis for the presence of intrathecal antibodies to Sarcocystis neurona, the causative agent of equine protozoal myeloencephalitis. Significantly abnormal EMG findings included spontaneous electrical activity of the tongue, suggesting denervation. The MRI was useful in ruling out masses, congenital anomalies and focal abscessation. The cytology of CSF revealed mild mononuclear reactivity. Western blot testing of CSF was positive, indicating the intrathecal presence of antibodies to S neurona. The foal was treated with pyrimethamine and trimethoprim-sulphadiazine for two months and returned to nearly normal neurologic status.
The Effect of Oral Sucrose on Exercise Tolerance in Patients with McArdle's Disease (2003)

This study suggests that the ingestion of sucrose before exercise can markedly improve exercise tolerance in patients with McArdle's disease. The treatment takes effect during the time when muscle injury commonly develops in these patients. In addition to increasing the patients' exercise capacity and sense of well-being, the treatment may protect against exercise-induced rhabdomyolysis.
Alignment and texture of thin liquid crystal films on solid substrates (1982)

Thin liquid crystal films in the range from 0.4 to 10 μm were thermally evaporated on solid surfaces. Semistable films were maintained on obliquely evaporated SiO surfaces that induce homeotropic, homogeneous, or tilted alignment. Realignment which violates the boundary conditions was observed in the smectic phase of thin films. The nematic phase of homogeneously aligned films has a peculiar two-domain texture indicative of a spontaneous twist due to conflicting and degenerate boundary conditions.
Surface Analysis II (2018)

Modifying objective functions, in general, does not make the optimization solution faster, but it can have advantages in visualizing the surface, in seeing issues, in scaling it for presentation, or in simplifying a calculation. If you modify the OF, however, you need to ensure that your modification does not change the DV* solution.
HLA-G Antigen and Parturition: Maternal Serum, Fetal Serum and Amniotic Fluid Levels during Pregnancy (2004)

sHLA-G1 antigen expression is higher in amniotic fluid than in maternal-fetal compartments and significantly decreases toward term. We speculate that the declining amniotic fluid sHLA-G1 levels may stimulate a maternal immunological response against the fetus and contribute to the initiation of parturition.
Bibliography (2013)

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Design, Synthesis, and Biological Activity of New N-(Phenylmethyl)-benzoxazol-2-thiones as Macrophage Migration Inhibitory Factor (MIF) Antagonists: Efficacies in Experimental Pulmonary Hypertension (2018)

Macrophage migration inhibitory factor (MIF) is a key pleiotropic mediator and a promising therapeutic target in cancer as well as in several inflammatory and cardiovascular diseases including pulmonary arterial hypertension (PAH). Here, a novel series of N-(phenylmethyl)-benzoxazol-2-thiones 5-32 designed to target the MIF tautomerase active site was synthesized and evaluated for its effects on cell survival. Investigation of structure-activity relationship (SAR) particularly at the 5-position of the benzoxazole core led to the identification of 31 that potently inhibits cell survival in DU-145 prostate cancer cells and pulmonary endothelial cells derived from patients with idiopathic PAH (iPAH-ECs), two cell lines for which survival is MIF-dependent. Molecular docking studies helped to interpret initial SAR related to MIF tautomerase inhibition and propose preferred binding mode for 31 within the MIF tautomerase active site. Interestingly, daily treatment with 31 started 2 weeks after a subcutaneous monocrotaline injection regressed established pulmonary hypertension in rats.
Guest Editorial (2020)

This transactions’ Mini-Special Issue includes 11 expanded articles from the 2019 IEEE Microwave Theory and Techniques Society (MTT-S) International Microwave Workshop Series on Advanced Materials and Processes (IMWS-AMP 2019), held in Bochum, Germany, on July 16–18, 2019.
The magnetic and quadrupole moment of oriented nuclei measured with the β-LMR-NMR (1998)

By combining two well established methods, the β-level mixing resonance (β-LMR) and the β-nuclear magnetic resonance (β-NMR), it is possible to determine the magnetic moment and the quadrupole moment of nuclei with low spin. The combined method can be applied on spin oriented ground state β-decaying nuclei. It was tested on the known 12B and successfully applied on the neutron rich 18N. We found for the magnetic moment μ(18N)=0.157(7)n.m. and for the quadrupole moment Q(18N)=30(3)mbarn.
Chondrogenesis with Stem Cells in Massive Chondral Defects: A Randomized Controlled Trial (2021)

Objectives: The purpose of this study was to evaluate the safety and efficacy of intra-articular injections of autologous peripheral blood stem cells (PBSC) with hyaluronic acid (HA) after arthroscopic subchondral drilling into massive chondral defects of the knee joint and to determine whether PBSC therapy can improve functional outcome and reduce pain of the knee joint better than the standard of care. Methods: This is a dual centre, US-FDA phase IIB randomized controlled trial (RCT). Sixty-nine patients age 18-55 years with International Cartilage Repair Society (ICRS) grade 3 and 4 chondral lesions (size ≥ 3cm 2 ) of the knee joint were randomized equally into (i) control group receiving intra-articular injections of HA plus physiotherapy (standard of care) and (ii) intervention group receiving arthroscopic subchondral drilling into chondral defects and postoperative intra-articular injections of PBSC with HA. The co-primary efficacy endpoints are subjective International Knee Documentation Committee (IKDC) and Knee Injury and Osteoarthritis Outcome Score (KOOS)-pain subdomain measured at month-24. The secondary efficacy endpoints include all other KOOS subdomains, Numeric Rating Scale (NRS) and Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) scores. Results: At 24 months, the mean IKDC scores for the control and intervention groups were 48.1 and 65.6, respectively ( P &lt; 0.0001). The mean for KOOS-pain subdomain scores were 59.0 (control) and 86.0 (intervention) with P &lt; 0.0001. All other KOOS subdomains, NRS and MOCART scores were statistically significant ( P &lt; 0.0001) at month-24. Figure 1 shows the bar graphs of the co-primary endpoints. Figure 2 shows the MRI images of: (A) ‘Bone-on-bone’ chondral defects of the lateral femoral condyle (white arrows) and lateral tibial plateau (yellow arrows) following subchondral drilling, with corresponding arthroscopic images and (B) the same lesions at 2 years after surgery showing full thickness articular cartilage regeneration There were no notable adverse events that are unexpected and related to the study drug or procedures. Conclusions: Arthroscopic subchondral drilling into massive chondral defects of the knee joint followed by postoperative intra-articular injections of autologous PBSC with HA is safe and showed a significant improvement of clinical and radiological scores as compared to the standard of care.
‘The whole dowry of all nature’ (2021)

Abstract Chapter 12, ‘The whole dowry of all nature: Opera omnia (1676–1720)’ provides a detailed bibliography, using the system described in chapter 4, of fifteen copies of Willis’s collected works in Latin, the eighth publication, containing treatises: 1–13, variously including William Croone’s treatise De ratione motus musculorum, and with the Latin translation of A plain and easie method for preserving those that are well from the infection of the plague also present in one edition (1695). These descriptions are preceded by a narrative highlighting the main bibliographic issues that characterize the various editions, states, and issues of these copies. Of these, some are already known but others newly identified. {100 words}
Butyrate protects Caco-2 cells from Campylobacter jejuni invasion and translocation (2008)

Invasion in and translocation across enterocytes are major events during Campylobacter jejuni-induced enteritis in humans. C. jejuni in vitro infection of cell monolayers typically results in loss of tight junction integrity, which could contribute to translocation. In the present study, we wanted to investigate whether butyrate is able to confer protection to Caco-2 cells against C. jejuni invasion, thus reducing paracellular permeability and limiting C. jejuni translocation. Protection of Caco-2 cells against C. jejuni invasion was assessed using a gentamicin protection assay. Transwell systems were used to investigate the impact of butyrate on translocation of C. jejuni across a Caco-2 monolayer and its effect on transepithelial resistance during infection. Butyrate protected Caco-2 cells against C. jejuni invasion in a concentration-dependent manner. Differentiated Caco-2 cells were less susceptible to C. jejuni invasion than 3-d-old undifferentiated cells and higher concentrations of butyrate and longer incubation times were needed to become refractive for invasion. C. jejuni translocation over Caco-2 monolayers was reduced when monolayers were treated with butyrate and this was accompanied by an enhanced drop in transepithelial resistance. The present study showed that butyrate is able to protect Caco-2 cells from two major virulence mechanisms of C. jejuni, namely invasion and translocation, but not from a decline in transepithelial resistance.
A High Fidelity, Micro-Structural and Anatomically Accurate 3D Finite Element Model for Functioning Heart Mitral Valve (2013)

Many surgeons have come to view mitral valve (MV) repair as the treatment of choice in patients with mitral regurgitation (MR) [1]. However, recent long-term studies have indicated that the recurrence of significant MR after repair may be much higher than previously believed, particularly in patients with (ischemic mitral regurgitation) IMR [2]. Since a significant number of these failures result from chordal, leaflet and suture line disruption, it has been suggested that excessive tissue stress and the resulting strain-induced tissue damage are important etiologic factors. We thus hypothesize that the restoration of homeostatic normal MV leaflet tissue stress levels in IMR repair techniques ultimately leads to improved repair durability through restoration of normal MV responses. Therefore, the objective of this study is to develop a novel high-fidelity and micro-anatomically accurate 3D finite element (FE) model that incorporates detailed collagen fiber architecture, realistic constitutive models, and micro-anatomically accurate valvular geometry to connect the cellular function of the MV tissues with the organ level mechanical responses, and to aid in the design of MV repair procedures.
Polarization diversity cognitive antenna for WiFi and ZigBee applications (2009)

The paper presents a cognitive antenna based on the self-structuring antenna (SSA) technology that dynamically alters its aperture to maximize signal-to-noise-ratio (SNR) in varying RF environments. A polarization-diversity antenna, which is a simple implementation of the SSA, has been built and tested for Wi-Fi applications. The low profile prototype uses self-structuring feed and has proved effective in improving signal strength and data rates, and is compatible with MIMO implementation.