gebhart/patrepeval huggingface dataset:
Quantitative Proteomic Analysis of Formalin-fixed and Paraffin-embedded Nasopharyngeal Carcinoma Using iTRAQ Labeling, Two-dimensional Liquid Chromatography, and Tandem Mass Spectrometry (2010)

Formalin-fixed, paraffin-embedded (FFPE) tissue specimens represent a potentially valuable resource for protein biomarker investigations. In this study, proteins were extracted by a heat-induced antigen retrieval technique combined with a retrieval solution containing 2% SDS from FFPE tissues of normal nasopharyngeal epithelial tissues (NNET) and three histological types of nasopharyngeal carcinoma (NPC) with diverse differentiation degrees. Then two-dimensional liquid chromatography-tandem mass spectrometry coupled with isobaric tags for relative and absolute quantification (iTRAQ) labeling was employed to quantitatively identify the differentially expressed proteins among the types of NPC FFPE tissues. Our study resulted in the identification of 730 unique proteins, the distributions of subcellular localizations and molecular functions of which were similar to those of the proteomic database of human NPC and NNET that we had set up based on the frozen tissues. Additionally, the relative expression levels of cathepsin D, keratin8, SFN, and stathmin1 identified and quantified in this report were consistent with the immunohistochemistry results acquired in our previous study. In conclusion, we have developed an effective approach to identifying protein changes in FFPE NPC tissues utilizing iTRAQ technology in conjunction with an economical and easily accessible sample preparation method.
Supplementary Figure from Safety and Activity of PolyPEPI1018 Combined with Maintenance Therapy in Metastatic Colorectal Cancer: an Open-Label, Multicenter, Phase Ib Study (2023)

Supplementary Figure from Safety and Activity of PolyPEPI1018 Combined with Maintenance Therapy in Metastatic Colorectal Cancer: an Open-Label, Multicenter, Phase Ib Study
Cardiovascular Simulator Improvement: Pressure Versus Volume Loop Assessment (2011)

This article presents improvement on a physical cardiovascular simulator (PCS) system. Intraventricular pressure versus intraventricular volume (PxV) loop was obtained to evaluate performance of a pulsatile chamber mimicking the human left ventricle. PxV loop shows heart contractility and is normally used to evaluate heart performance. In many heart diseases, the stroke volume decreases because of low heart contractility. This pathological situation must be simulated by the PCS in order to evaluate the assistance provided by a ventricular assist device (VAD). The PCS system is automatically controlled by a computer and is an auxiliary tool for VAD control strategies development. This PCS system is according to a Windkessel model where lumped parameters are used for cardiovascular system analysis. Peripheral resistance, arteries compliance, and fluid inertance are simulated. The simulator has an actuator with a roller screw and brushless direct current motor, and the stroke volume is regulated by the actuator displacement. Internal pressure and volume measurements are monitored to obtain the PxV loop. Left chamber internal pressure is directly obtained by pressure transducer; however, internal volume has been obtained indirectly by using a linear variable differential transformer, which senses the diaphragm displacement. Correlations between the internal volume and diaphragm position are made. LabVIEW integrates these signals and shows the pressure versus internal volume loop. The results that have been obtained from the PCS system show PxV loops at different ventricle elastances, making possible the simulation of pathological situations. A preliminary test with a pulsatile VAD attached to PCS system was made.
Diagnostic imaging of cervical intraepithelial neoplasia based on hematoxylin and eosin fluorescence (2015)

Presently, there are no markers to help in classification of CIN I-III lesions. Our imaging method may complement standard H&E pathological review and provide objective criteria to support the CIN diagnosis.
Short-range order, bulk moduli, and physical trends in c-Si1−xCxalloys (1997)

Alloys of silicon and carbon in the crystalline phase, although complex and with varying degrees of short-range order, are shown to exhibit an accurate power-law dependence of the bulk modulus B on the average nearest-neighbor separation d, over the whole composition range. The homopolar energy gap of these alloys increases with carbon content. Similar trends have only been proposed earlier for the much simpler diamond and zinc-blende semiconductors.
Systemic adjuvant therapy for breast cancer (1993)

The use of systemic (drug) therapy postoperatively reduces the risk of relapse and death for patients with resectable invasive breast cancer. The Early Breast Cancer Trialists' Collaborative Group overview analysis confirmed the benefits of both polychemotherapy and tamoxifen in broad subgroups of patients. It remains a challenge, however, to quantify the risk of relapse and the benefit of therapy for individual patients. If the ipsilateral lymph nodes are free of metastases and the tumor is infiltrating ductal or lobular in histology and less than 1 cm in diameter, the risk of relapse is low, so the benefits of standard treatments are too small to warrant routine use. For node-negative patients with larger tumors or for those with positive lymph nodes, the benefits of therapy are significant, although many of these individual patients will not relapse. Hence, better prognostic methods, improving the accuracy of predicting an individual patient's risk, could allow for more rational treatment recommendations. The most widely used polychemotherapy combination incorporates three drugs: cyclophosphamide, methotrexate, and fluorouracil. The substitution or inclusion of doxorubicin, which is somewhat more toxic than the cyclophosphamide, methotrexate, and fluorouracil regimen, is justifiable in subsets of patients at higher risk of relapse, eg, those with metastatic involvement of four or more axillary lymph nodes. Because higher dose intensity (the amount of drug given per unit time) of chemotherapy improves relapse-free survival, phase II clinical trials are testing various dose-intensification strategies, and phase III trials are underway to determine their comparative efficacy.(ABSTRACT TRUNCATED AT 250 WORDS)
Application of Laser Ablation ICP-AES to Steel Analysis (1997)

A new system of the laser ablation-ICP (Inductively Coupled Plasma) AES (Atomic Emission Spectrometry ) was developed for rapid analysis of steels. A lamp pumped Nd; YAG laser or a laser diode pumped solid-state laser is used for ablating samples with the Q-switched mode of high pulse repetition rate. The optical system for the laser radiation is adjusted to satisfy a criterion of laser energy density. The optics is also adjusted to scan the laser beam in the whole area of a square repeatedly. The composition of particles generated by the system is almost the same as that of the solid matrix, and their sizes are<0.1μm and near uniform. These features of particles bring high sensitivity and precision to this system.The developed laser-ICP system shows some analytical merits superior to the spark source AES. The analytical performances of this system are excellent precision in the trace level concentration, good linearity of analytical curve, little or no sample preparation, the ability of the analysis of hot samples (1000°C), accurate control of analytical point. On carbon determination in steel, the influence of metallurgical history which causes the serious error in the spark source AES, is not appeared in the developed system.The developed laser-ICP system has been applied to two analytical systems in steelmaking works. One is a full automatic analyzing system of steel product samples and the other is a rapid analyzer of defects in steel sheets. Both of the systems are working smoothly.
Preventive surgery after multiplex genetic panel testing (MGPT). (2019)

1525 Background: Guidelines recommend consideration of prophylactic surgery for patients with a germline pathogenic variant in some cancer predisposition genes. We assessed surgery utilization in a prospective, multi-institutional cohort study of MGPT. Methods: 2000 patients had MGPT and completed questionnaires at 3, 6, and 12 months. Patients reported surgical utilization and indication (treatment or prevention). Surgery utilization was assessed according to cancer history and MGPT test results: Positive, pathogenic variant; VUS, variant of uncertain significance; Negative, benign variants. Results: Overall, 12.9% (198/1537) of patients reported surgery after MGPT (median follow-up 13 months). Only 31.3% (62/198) of patients specified that their surgery was preventive. Preventive surgery utilization was significantly higher among patients who tested positive (n=30, 14.9%) compared to those testing negative (n=20, 2.3%, p&lt;0.001) or VUS (n=12, 2.2%, p&lt;0.001). Preventive surgery was very low among patients testing negative or VUS who had no personal history of cancer in the relevant organ (Table). For example, mastectomy was not reported among any patients testing negative or VUS who had no personal history of breast cancer (Table). Conclusions: More than one year after MGPT, prophylactic surgery use was low among patients with VUS or negative results, especially among those with no personal history of cancer at the relevant site. Surgery utilization. [Table: see text]
Hybrid Extracellular Vesicles‐Liposomes Camouflaged Magnetic Vesicles Cooperating with Bioorthogonal Click Chemistry for High‐Efficient Melanoma Circulating Tumor Cells Enrichment (2023)

The capture of melanoma circulating tumor cells (melanoma CTCs, MelCTCs) is of great significance for the early diagnosis and personalized treatment of melanoma. The rarity and heterogeneity of MelCTCs have greatly limited the development of MelCTCs capture methods, especially those based on immune/aptamer-affinity. Herein, an extracellular vesicles-camouflaged strategy is designed to functionalize the magnetic nanoparticles (Fe<sub>3</sub> O<sub>4</sub> ) and to generate magnetic vesicles (Fe<sub>3</sub> O<sub>4</sub> @lip/ev) with excellent antifouling and active tumor cell targeting properties. Combined with the bioorthogonal click chemistry, the engineered magnetic vesicles with dibenzocyclooctyne can be widely used to target and separate all the metabolically labeled CTCs with varied phenotypes, organ origin, and even the biological species. The capture efficiency exceeded 80% with an extremely low detection limitation of ten cells. Most importantly, the strategy proposed can be directly applied to enrich MelCTCs from 0.5 mL blood samples of melanoma-bearing mice, with a greatly minimized residue of white blood cells (only 21-568) while ignoring the fluctuations of MelCTC phenotype.
Development of small-sized pixel structures for high-resolution CMOS image sensors (2017)

We present our studies on small-sized pixel structures for high-resolution CMOS image sensors. To minimize the number of pixel components, single-transistor pixel and 2T pixel architecture were proposed. To deal with crosstalk between pixels, MOS capacitor deep trench isolation (CDTI) was integrated. CDTI-integrated pixel allows better achievements in dark current and full-well capacity in comparison with the configuration integrating oxide-filled deep trench isolation (DTI). To improve quantum efficiency (QE) and minimize optical crosstalk, back-side illumination (BSI) was developed. Also, vertical photodiode was proposed to maximize its charge-collection region. To take advantages of these structures/technologies, we developed two pixel options (P-type and N-type) combining CDTI or DTI, BSI and vertical photodiode. All the presented pixel structures were designed in 1.4μm-pitch sensor arrays, fabricated and tested.
Accurate and low complexity polynomial and neural network models for PA digital pre-distortion (2016)

In this paper, new polynomial and neural network models for power amplifier digital pre-distortion are introduced. The motivation behind the suggested models is having low complexity models that maintain good error performances. Also, this paper discusses the comparison between polynomial and neural network models in terms of model complexity and error performance before and after applying a compressed sensing algorithm. Furthermore, the proposed neural network model is a low complexity model that does not require a compressed sensing algorithm to reduce its number of model parameters, yet the proposed neural network model achieves good NMSE(dB) error performance.
Parafoveal Retinal Vascular Response to Pattern Visual Stimulation Assessed with OCT Angiography (2013)

We used optical coherence tomography (OCT) angiography with a high-speed swept-source OCT system to investigate retinal blood flow changes induced by visual stimulation with a reversing checkerboard pattern. The split-spectrum amplitude-decorrelation angiography (SSADA) algorithm was used to quantify blood flow as measured with parafoveal flow index (PFI), which is proportional to the density of blood vessels and the velocity of blood flow in the parafoveal region of the macula. PFI measurements were taken in 15 second intervals during a 4 minute period consisting of 1 minute of baseline, 2 minutes with an 8 Hz reversing checkerboard pattern stimulation, and 1 minute without stimulation. PFI measurements increased 6.1±4.7% (p = .001) during the first minute of stimulation, with the most significant increase in PFI occurring 30 seconds into stimulation (p<0.001). These results suggest that pattern stimulation induces a change to retinal blood flow that can be reliably measured with OCT angiography.
Gesture-based human-robot Jazz improvisation (2010)

We present Shimon, an interactive improvisational robotic marimba player, developed for research in Robotic Musicianship. The robot listens to a human musician and continuously adapts its improvisation and choreography, while playing simultaneously with the human. We discuss the robot's mechanism and motion-control, which uses physics simulation and animation principles to achieve both expressivity and safety. We then present a novel interactive improvisation system based on the notion of gestures for both musical and visual expression. The system also uses anticipatory beat-matched action to enable real-time synchronization with the human player. Our system was implemented on a full-length human-robot Jazz duet, displaying highly coordinated melodic and rhythmic human-robot joint improvisation. We have performed with the system in front of a live public audience.
Cell Cycle Arrest and Induction of Apoptosis by Lycopene in LNCaP Human Prostate Cancer Cells (2004)

Lycopene is one of the major carotenoids and is found almost exclusively in tomatoes and tomato products. Since tomato consumption is associated with decreased risk of prostate cancer, characterizing the effects of lycopene on cell growth or survival, cell cycle progression, and apoptosis in LCNaP human prostate cancer cells might elucidate the mechanisms of actions of lycopene. To discover the possible anti-cancer mechanism of lycopene, water-soluble lycopene was used, and cell cycle arrest and apoptosis were measured. Placebo formulation at each lycopene dose at 0.1, 1, and 5 microM was used as a control. After 6, 24, and 48 hours of incubation, cells were harvested and measured for cell viability. Lycopene at 1 microM inhibited cell growth by 31%, compared with its placebo formulation after a 48-hour incubation. Lycopene at 5 microM increased the number of cells in the G(2)/M phase of the cell cycle from 13% to 28% and decreased S-phase cells from 45% to 29%, while no shifts in cell cycle were detected in placebo-treated groups. Apoptosis was observed at the 5 microM lycopene formulation at the late stages during the 24- and 48-hour treatments. Lycopene, therefore, deserves further study as a potential chemopreventive/chemotherapeutic agent.
Racial and Ethnic Inequities in Postpartum Pain Evaluation and Management (2019)

Racial and ethnic inequities in the experience, assessment and treatment of postpartum pain were identified. A limitation of our study is that we were unable to assess the role of patient beliefs about expression of pain, patient preferences with regards to pain medication, and beliefs and potential biases among health care providers.
Award-Winning Organometallic Chemistry: The 2012 Strem Chemicals Award for Pure or Applied Inorganic Chemistry of the Canadian Society for Chemistry1 (2013)

ADVERTISEMENT RETURN TO ISSUEEditor's PageNEXTAward-Winning Organometallic Chemistry: The 2012 Strem Chemicals Award for Pure or Applied Inorganic Chemistry of the Canadian Society for Chemistry1John A. GladyszCite this: Organometallics 2013, 32, 21, 6147Publication Date (Web):November 11, 2013Publication History Published online11 November 2013Published inissue 11 November 2013https://pubs.acs.org/doi/10.1021/om400947yhttps://doi.org/10.1021/om400947yeditorialACS PublicationsCopyright © 2013 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views492Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (761 KB) Get e-AlertscloseSUBJECTS:Inorganic chemistry,Ligands,Organometallic chemistry,Reactivity Get e-Alerts
Abstract 2270: A BRCA1 deficient, NFκB driven immune signal predicts good outcome in triple negative breast cancer (2016)

Abstract Triple negative (TNBCs) and the closely related Basal-like (BLBCs) breast cancers are a loosely defined collection of cancers with poor clinical outcomes. Both show strong similarities with BRCA1-mutant breast cancers and BRCA1 dysfunction, or ‘BRCAness’, is observed in a large proportion of sporadic BLBCs. BRCA1 expression and function has been shown in vitro to modulate responses to radiation and chemotherapy. Exploitation of this knowledge in the treatment of BRCA1-mutant patients has had varying degrees of success. This reflects the significant problem of accurately detecting those patients with BRCA1 dysfunction. Moreover, not all BRCA1 mutations/loss of function result in the same histology/pathology or indeed have similar effects in modulating therapeutic responses. Given the poor clinical outcomes and lack of targeted therapy for these subtypes, a better understanding of the biology underlying these diseases is required in order to develop novel therapeutic strategies. We have discovered a consistent NFκB hyperactivity associated with BRCA1 dysfunction as a consequence of increased Reactive Oxygen Species (ROS). This biology is found in a subset of BRCA1-mutant and triple negative breast cancer cases and confers good outcome. The increased NFκB signalling results in an anti-tumour microenvironment which may allow CD8+ cytotoxic T cells to suppress tumour progression. However, tumours lacking this NFκB-driven biology have a more tumour-promoting environment and so are associated with poorer prognosis. Tumour-derived gene expression data and cell line models imply that these tumours may benefit from alternative treatment strategies such as reprogramming the microenvironment and targeting the IGF and AR signalling pathways. Citation Format: Niamh E. Buckley, Paula Haddock, Ricardo De Matos Simoes, Eileen Parkes, Gareth Irwin, Frank Emmert-Streib, Stephen McQuaid, Richard D. Kennedy, Paul B. Mullan. A BRCA1 deficient, NFκB driven immune signal predicts good outcome in triple negative breast cancer. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 2270.
CAPACITY MODULATION OF LINEAR COMPRESSOR FOR HOUSEHOLD REFRIGERATOR (2004)

The energy consumption of a refrigerator depends not only on the efficiency of compressor itself, but also on the capacity modulation. The capacity of linear compressor has not been modulated successively yet, while the linear compressor has high efficiency. Therefore we have studied following several methods of capacity modulation for the linear compressor. For those methods we used triac based drive instead of inverter drive which is usually used for capacity modulation in reciprocating compressor. (1) Clearance Volume Adjustment Method (2) Line Driving Method (3) Swept Volume Adjustment Method (4) Two Stage Compression Method (5) Two Compressor Method We compared the efficiencies of those methods and found which is the most effective for the energy saving in the household refrigerator.
cJVM: a single system image of a JVM on a cluster (2003)

cJVM is a Java Virtual Machine (JVM) that provides a single system image of a traditional JVM while executing on a cluster. cJVM virtualizes the cluster, supporting any pure Java application without requiring any code modifications. By distributing the application's work among the cluster's nodes, cJVM aims to obtain improved scalability for Java Server Applications. cJVM uses a novel object model which distinguishes between an application's view of an object and its implementation (e.g., different objects of the same class may have different implementations). This allows us to exploit knowledge on the usage of individual objects to improve performance. cJVM is work-in-progress. Our prototype runs on a cluster of IBM IntelliStations running Win/NT and are connected via a Myrinet switch. It provides a single system image to applications, distributing the application's threads and objects over the cluster. We have used cJVM to run without change a real Java application containing over 10Kloc and have achieved linear speedup for another application with a large number of independent threads. This paper discusses cJVM's architecture and implementation, showing how to provide a single system image of a traditional JVM on a cluster.
Comparison of the ‘Chemical’ and ‘Structural’ Approaches to the Optimization of the Thrombin-Binding Aptamer (2014)

Noncanonically structured DNA aptamers to thrombin were examined. Two different approaches were used to improve stability, binding affinity and biological activity of a known thrombin-binding aptamer. These approaches are chemical modification and the addition of a duplex module to the aptamer core structure. Several chemically modified aptamers and the duplex-bearing ones were all studied under the same conditions by a set of widely known and some relatively new methods. A number of the thrombin-binding aptamer analogs have demonstrated improved characteristics. Most importantly, the study allowed us to compare directly the two approaches to aptamer optimization and to analyze their relative advantages and disadvantages as well as their potential in drug design and fundamental studies.