gebhart/patrepeval huggingface dataset:
Bovine Pinealocytes in Monolayer Culture: Studies on the Adrenergic Regulation of Melatonin Secretion (1991)

Most of what is known regarding adrenergic control of mammalian pineal functions has been derived from investigations with rodents. In an effort to provide a new animal model for pineal research, the bovine pineal gland was selected for practical and theoretical reasons. Bovine pinealocytes in monolayer culture were first characterized in terms of optimal culture conditions, i.e. medium requirements, cell density, preincubation duration and stimulation times. In Dulbecco's minimum essential medium/Ham's F12 medium, 2 x 10(5) cells per well preincubated for 6 days and stimulated for 8 h resulted in large increases in melatonin (mel) release (15- to 17-fold) after adrenergic stimulation. Likewise, cAMP accumulation within 10 min of stimulation increased 4- to 8-fold. (Bu)2cAMP (10(-5)-10(-3) M) produced a significant elevation in MEL secretion. Neither adrenergic dose-response studies, adrenergic antagonist studies nor experiments in which alpha- and beta-agonists were added together provided any evidence for a positive alpha/beta synergism on either MEL release or cAMP accumulation by bovine pinealocytes. This culture system should prove useful for identifying species differences in the signal transduction mechanisms underlying the activation of MEL secretion in the mammalian pineal.
Synthesis and Structure of Ph2P(S)N TiCl2 · 3C5H5N, the First Imidotitanium Complex (1990)

Coordination of electron pair donors at the titanium atom leads to stabilization of imidotitanium complexes, which are of interest as catalysts for C‐H activations and polymerizations. Thus, reaction of the thiophosphinic acid amide 1 with TiCl 4 and subsequent treatment of the initial product with pyridine enables the synthesis of the orange‐red, crystalline title compound 2 . The titanium atom exhibits distorted octahedral coordination; the length of the Ti‐N bond is 172.0(2) pm. equation image
Caractérisation par spectroscopie optique des classes tissulaires rencontrées lors de résection chirurgicale des carcinomes cutanés (2018)

National audience
High-sensitivity hyper-spectral video endoscopy system for intra-surgical tissue classification (2010)

Modern video endoscopy systems give physicians the ability to inspect internal structures of the human body by using a camera with attached endoscope optics. Video endoscopy has become routine in clinics all over the world. Moreover, video endoscopy systems recently performed a technological change from PAL/NTS C image resolution to HDTV. There is a vast amount of literature on in-vivo and in-vitro experiments with multi-spectral point and imaging instruments. The literature demonstrates that document that the spectral information can provide valuable support for diagnosis. Due to the fact that spectral imaging equipment was too slow to acquire hyper-spectral image stacks at reasonable video rates, intra-surgery hyper spectral measurements were limited to point measurements in the past. But the availability of fast and versatile acousto optical tunable filters (AOTF) with switching times in the microsecond range made the application of a hyper-spectral video endoscope technically feasible. This paper describes a demonstrator of a hyper-spectral video endoscope and the results of the first clinical studies. The results show that hyper-spectral video endoscopy exhibits a large potential to become an important imaging technology for medical imaging devices that provide additional diagnostic information about the tissue under investigation.
Feasibility Study of Photovoltaic Panels in Military Temporary Housing Structures (2013)

Energy consumption by the US Army is becoming an increasingly important issue. The cost of providing fuel to Army outposts in deployed environments is particularly expensive due to numerous precautions required to defend fuel convoys from enemy attacks. This work is part of the Army's Construction Engineering Research Laboratory (CERL) efforts to reduce the amount of energy consumed by temporary barracks structures commonly referred to as “B-Huts”. A prototype is being developed utilizing structurally insulated panels (SIP) and is referred to as a “SIP-Hut”. This paper explores the benefits of incorporating photovoltaic (PV) panels into the SIP-Hut's power system. Powering a SIP-Hut is a unique challenge because SIP-Huts are typically located in remote and dangerous locations and, in addition, are temporary structures. A main thrust of this work was to examine if PV could be economically beneficial within this unique environment and short time span. However, the findings from this study can be applied to other remote locations where fossil fuels are not readily available. The SIP-Hut was modeled, solar resources estimated and analysis was performed using Hybrid Optimization Model for Electric Renewable (HOMER) software. Our analysis indicates that PV incorporation can have a significant positive impact on the amount of diesel fuel consumed and the overall cost of energy production.
Poly-N-Acetyl Glucosamine-SO<sub>4</sub> for Repairing Osteochondral Defect in Rabbits (2005)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Plasmonically enhanced spectrally selective narrowband MWIR and LWIR\n light detection based on hybrid nanopatterned graphene and phase changing\n vanadium oxide heterostructure operating close to room temperature (2021)

We present the model of an ultrasensitive mid-infrared (mid-IR) photodetector\noperating in the mid-wavelength infrared (MWIR) and long-wavelength infrared\n(LWIR) domains consisting of a hybrid heterostructure made of nanopatterned\ngraphene (NPG) and vanadium dioxide (VO$_2$) which exhibits a large\nresponsivity of $R\\sim 10^4$ V/W, a detectivity exceeding $D^*\\sim 10^{10}$ J,\nand a sensitivity in terms of noise-equivalent power $\\mathrm{NEP}\\sim 100$\nfW/$\\sqrt{\\rm Hz}$ close to room temperature by taking advantage of the phase\nchange of a thin VO$_2$ film. Our proposed photodetector can reach an\nabsorption of nearly 100\\% in monolayer graphene due to localized surface\nplasmons (LSPs) around the patterned circular holes. The geometry of the\nnanopattern and an electrostatic gate potential can be used to tune the\nabsorption peak in the mid-IR regime between 3 and 12 $\\mu$m. After the photon\nabsorption by the NPG sheet and the resulting phase change of VO$_2$ from\ninsulating to metallic phase the applied bias voltage $V_b$ triggers a current\nthrough the VO$_2$ sheet, which can be detected electronically in about 1 ms,\nshorter than the detection times of current VO$_2$ bolometers. Our envisioned\nmid-IR photodetector reaches detectivities of cryogenically cooled HgCdTe\nphotodetectors and sensitivities larger than VO$_2$ microbolometers while\noperating close to room temperature.\n
An analytical comparison of periodic checkpointing and incremental state saving (1993)

The successful application of optimistic synchronization techniques in parallel simulation requires that rollback overheads be contained. The chief contributions to rollback overhead in a Time Warp simulation are the time required to save state information and the time required to restore a previous state. Two competing techniques for reducing rollback overhead are periodic checkpointing (Lin and Lazowska, 1989) and incremental state saving (Bauer et al., 1991). This paper analytically compares the relative performance of periodic checkpointing to incremental state savings. The analytical model derived for periodic checkpointing is based almost entirely on the previous model developed by Lin (Lin and Lazowska, 1989). The analytical model for incremental state saving has been developed for this study. The comparison assumes an optimal checkpoint interval and shows under what simulation parameters each technique performs best.
Impact of spectral hole burning in multichannel amplification of EDFA (2004)

We model the gain variation due to the signal allocation change in multichannel EDFA amplification by introducing the effect of spectral hole burning (SHE). Our numerical model, describing the behavior of both positive and negative gain variation near to 1530 nm, gives good results in agreement with the measure results.
Organic Photochromism (2016)

This technical report is a general introduction to organic photochromism. The definition of photochromism (PC) is given together with that of words with the ending “chromism”, such as thermo-, electro-, piezo-, and tribochromism. Important concepts such as two-photon, gated, dual-mode PC and chirochromism are illustrated. The concept of fatigue (chemical degradation) and the determination of the main photochromic parameters (number of cycles, cyclability, half-life), and the spectrokinetic and mechanistic aspects are discussed. The main families of PC (organic compounds and biological receptors) are illustrated with chemical formulae, and the different types of reactions involved in the photochromic processes (pericyclic reactions, E/Z isomerization, group transfer, etc.) are listed. Some examples of applications to “optical power limiting” substances, photoresponsive materials, and photoswitchable biomaterials are considered.
Regenerated Cellulose and Willow Lignin Blends as Potential Renewable Precursors for Carbon Fibers (2018)

We report on the extraction of lignin from willow and its use to manufacture cellulose-lignin fibers as potential precursors for the manufacture of carbon fibers. The lignin from willow was extracted using triethylammonium hydrogen sulfate [Et3NH][HSO4]. The lignin extracted by this process was characterized by ATR-IR and elemental analysis, which indicated a high carbon yield. 1-Ethyl-3-methylimidazolium acetate [C2C1im][OAc] was then used as a common solvent to dissolve cellulose and lignin to manufacture lignin-cellulose fiber blends. The Young’s modulus of a 75:25 lignin/cellulose fiber was found to be 3.0 ± 0.5 GPa, which increased to 5.9 ± 0.6 GPa for a 25:75 lignin/cellulose blend. From a characterization of the surface morphology, using scanning electron microscopy (SEM) and atomic force microscopy (AFM), it was observed that higher lignin content in the fiber blend increased the surface roughness. FT-IR analysis confirmed the presence of aromatic groups related to lignin in the obtained fibers from the presence of peaks located at ∼1505 cm–1 and ∼1607 cm–1. The presence of lignin improves the thermal stability of the fiber blends by allowing them to degrade over a wider temperature range. The presence of lignin also improved the carbon yield during carbonization. Therefore, the lignin-cellulose fibers developed in this work can offer an excellent alternative to pure cellulose or lignin filaments.
Genome-wide association study identifies loci on 12q24 and 13q32 associated with Tetralogy of Fallot (2013)

We conducted a genome-wide association study to search for risk alleles associated with Tetralogy of Fallot (TOF), using a northern European discovery set of 835 cases and 5159 controls. A region on chromosome 12q24 was associated (P = 1.4 × 10(-7)) and replicated convincingly (P = 3.9 × 10(-5)) in 798 cases and 2931 controls [per allele odds ratio (OR) = 1.27 in replication cohort, P = 7.7 × 10(-11) in combined populations]. Single nucleotide polymorphisms in the glypican 5 gene on chromosome 13q32 were also associated (P = 1.7 × 10(-7)) and replicated convincingly (P = 1.2 × 10(-5)) in 789 cases and 2927 controls (per allele OR = 1.31 in replication cohort, P = 3.03 × 10(-11) in combined populations). Four additional regions on chromosomes 10, 15 and 16 showed suggestive association accompanied by nominal replication. This study, the first genome-wide association study of a congenital heart malformation phenotype, provides evidence that common genetic variation influences the risk of TOF.
Ranging energy optimization for robust sensor positioning with collaborative anchors (2010)

We propose a sensor positioning scheme for a wireless sensor network consisting of beacons as well as collaborative anchors (CA) to help sensors within a prescribed service area to locate themselves. We assume a robust performance is achieved in the sense that a prescribed location accuracy requirement is fulfilled within the service area. Under the assumption that the time-of-arrival and location estimators adopted achieve the associated Cramér-Rao bound, the performance of the location scheme is derived and analyzed. A ranging energy optimization problem is proposed, and a practical algorithm is presented. The effectiveness of this algorithm is illustrated by numerical experiments.
Identification of a peptide specifically targeting ovarian cancer by the screening of a phage display peptide library (2016)

Ovarian cancer is the most common cause of cancer-associated mortality in terms of gynecological malignancies, and is difficult to diagnose due to the absence of reliable biomarkers. To identify ovarian cancer-specific biomarkers, the present study used a Ph.D.-7™ Phage Display Peptide Library to screen for ligands that selectively target HO-8910 ovarian cancer cells. Following 5 rounds of biopanning, the phage clone P2 was selected by enzyme-linked immunosorbent assay and DNA sequencing, and its characteristics were additionally validated by immunofluorescence and immunohistochemical assays. The results revealed the positive phage were enriched 92-fold following 5 rounds of biopanning, and the DNA sequence AAC CCG ATG ATT CGC CGC CAG (amino acid sequence, NPMIRRQ) was repeated most frequently (phage clones, P2, P3, P15, P30 and P54). Immunofluorescence and immunohistochemical assays revealed that the phage clone P2 was able to bind to ovarian cancer cells and tissues, and not those of cervical cancer. In conclusion, the peptide NPMIRRQ may be a potential agent for the diagnosis of ovarian cancer.
Single camera lane detection and tracking (2005)

In this paper we present a method to detect and track straight lane boundaries, using a forward-looking single camera mounted on-board. The method proved to be robust, even under varying lighting conditions, and in the presence of heavy shadowing cast by vegetation, vehicles, bridges, etc. Moreover, false positive hardly occur. The lane markings are being continuously detected even when the vehicle is performing maneuvers such as excursion or lane change. The performance is achieved by a novel combination of methods, namely, by first finding vanishing point candidates for the lane boundaries, and later by the careful selection of line segments given a vanishing point, and finally by using a smart heuristics to select the whole set of four lane boundaries. Suppression of false positives is further achieved by tracking the vanishing point, and by constraining the lane width based on recent history.
Altering the Substrate Specificity of Organophosphorus Hydrolase for Enhanced Hydrolysis of Chlorpyrifos (2004)

Chlorpyrifos is one of the most popular pesticides used for agriculture crop protection, and widespread contamination is a potential concern. However, chlorpyrifos is hydrolyzed almost 1,000-fold slower than the preferred substrate, paraoxon, by organophosphorus hydrolase (OPH), an enzyme that can degrade a broad range of organophosphate pesticides. We have recently demonstrated that directed evolution can be used to generate OPH variants with up to 25-fold improvement in hydrolysis of methyl parathion. The obvious question and challenge are whether similar success could be achieved with this poorly hydrolyzed substrate, chlorpyrifos. For this study, five improved variants were selected from two rounds of directed evolution based on the formation of clear haloes on Luria-Bertani plates overlaid with chlorpyrifos. One variant, B3561, exhibited a 725-fold increase in the k(cat)/K(m) value for chlorpyrifos hydrolysis as well as enhanced hydrolysis rates for several other OP compounds tested. Considering that wild-type OPH hydrolyzes paraoxon at a rate close to the diffusion control limit, the 39-fold improvement in hydrolysis of paraoxon by B3561 suggests that this variant is one of the most efficient enzymes available to attack a wide spectrum of organophosphate nerve agents.
Abstract 10565: Personalized Virtual Heart Approach Representing Fatty Infiltration (inFAT) in Arrhythmogenic Right Ventricular (RV) Cardiomyopathy (ARVC) Predicts Ventricular Arrhythmia (VA) Reentrant Circuits and Ablation Targets: A Pilot Study (2022)

Introduction: inFAT is a pathological hallmark in ARVC that is associated with pro-arrhythmic remodeling that contributes to the substrate for VA. Identification of the inFAT distribution on contrast-enhanced computed tomography (CE-CT), which is highly accessible and has reliable image quality, may be useful in pre-procedural planning for catheter ablation treatment of VA. Objective: We aimed to develop and validate a novel non-invasive CT-based computational approach for VA ablation targeting in ARVC. Methods: As a retrospective pilot study, we constructed 3D personalized computational models of ARVC patient hearts with implanted cardioverter defibrillators from CE-CT scans representing the patient-specific inFAT distribution in the RV (Fig A, B). Three patients were included. P1 and P2 had clinical VA and electrophysiological study with ablation. P3 did not present with clinical VA and did not have ablation. We evaluated the inducibility of each model via rapid pacing and compared the results to electroanatomic voltage maps (EAM). In-silico ablation was performed and compared to clinical ablation locations (Fig C). Results: For all 3 patients, heart model predictions corresponded well with clinical observations.In both P1 and P2, reentrant circuits’ locations matched clinical records (Fig C). Both reentrant circuits manifested at the border of inFAT and fat-myocardium admixture, where tissue heterogeneity was prominent. Regions of inFAT co-localized well with low-voltage areas on EAM. Predicted ablation sites successfully terminated VA and coincided with the clinical ablation locations. In P2, the predicted ablation yielded a much smaller lesion than clinical ablation. For P3, the model correctly predicted that VA could not be induced in the heart. Conclusions: Our novel ARVC CT-based computational approach accurately predicts VA ablation targets and could potentially become a highly accessible tool in assisting ARVC ablation.
Research in Biomechanics of Occupant Protection (1995)

This paper discusses the biomechanical bases for occupant protection against frontal and side impact. Newton's Laws of Motion are used to illustrate the effect of a crash on restrained and unrestrained occupants, and the concept of ride down is discussed. Occupant protection through the use of energy absorbing materials is described, and the mechanism of injury of some of the more common injuries is explained. The role of the three-point belt and the airbag in frontal protection is discussed along with the potential injuries that can result from the use of these restraint systems. Side impact protection is more difficult to attain but some protection can be derived from the use of padding or a side impact airbag. It is concluded that the front seat occupants are adequately protected against frontal impact if belts are worn in an airbag equipped vehicle. Side impact protection may not be uniform in all vehicles.
Spatial Subsampling in Motion-Compensated Television Coders (1982)

Motion-compensated television coders generate data at a nonuniform rate, which is smoothed by a buffer for transmission over a channel of constant bit rate. Spatial subsampling is one of the methods used to prevent overflow of the buffer, which would otherwise occur for scenes with complex motion from frame to frame. In this paper we evaluate the effects of spatial subsampling on the performance of motion-compensated coders. In particular, we find that, although the quality of motion estimation does degrade in the presence of subsampling, the degradation is not substantial. Use of 2:1 horizontal subsampling, for example, results in bit rates that are 50 percent lower compared with no subsampling for motion-compensated coders. This percentage is approximately the same for the conditional-replenishment coders. Spatial subsampling generally results in blurring of the picture. We describe a technique for adaptive interpolation that results in blurring of only the unpredictable areas of the picture. The subjective quality in the presence of subsampling is thus improved considerably. In conclusion, our techniques for subsampling in a motion-compensated coder reduce the bit rate approximately by the same factor as subsampling in a conditional-replenishment coder, but result in a much better picture quality.
ChemInform Abstract: Synthesis of 3‐Amino‐6‐methyl‐5‐ethoxycarbonyl‐4,7‐dihydrothieno‐(2,3‐b)pyridine Derivatives. (1987)

Abstract Alkylation of the dihydropyridinethiolates (I) with the haloacetonitriles or haloacetamides (II) gives the 2‐cyanomethylthio or 2‐carbamoylmethylthio substituted dihydropyridines (III).
Mechanisms of Dynamic Cardiomyoplasty: Current Concepts (1996)

Dynamic cardiomyoplasty is an operation that is undergoing worldwide clinical evaluation. It had been developed to utilize the patient's own skeletal muscle to assist the failing heart. Although the clinical and quality of life benefits of cardiomyoplasty have been reported in most patients, the results of quantitative hemodynamic analyses have been less consistent. This has prompted the reevaluation of the mechanisms of dynamic cardiomyoplasty other than simple cardiac compression by the wrapped muscle. There is good evidence to suggest that the following, either together or in part, comprise some of the mechanisms of dynamic cardiomyoplasty: (1) direct systolic assist; (2) myocardial (wall stress) sparing effect; (3) remodeling/girdling effect; and (4) angiogenesis. Current concepts and potential additional mechanisms are discussed and integrated, based on a review of the literature and our own recent studies.
Enantioselective C−C Bond Cleavage Creating Chiral Quaternary Carbon Centers (2006)

[Structure: see text] A chiral all-carbon benzylic quaternary carbon center is created by the asymmetric intramolecular addition/ring-opening reaction of a boryl-substituted cyclobutanone, which involves enantioselective beta-carbon elimination from a symmetrical rhodium cyclobutanolate. The asymmetric reaction was successfully applied to a synthesis of sesquiterpene, (-)-alpha-herbertenol.
Synthesis of bimetallic gold–silver alloy nanoclusters by simple mortar grinding (2012)

A macroscale quantity of bimetallic Au-Ag alloy nanoclusters was achieved through sequential reduction by simple mortar grinding. The chitosan biopolymer was used as both a stabilizing and reducing agent. These nanoclusters exhibit excellent catalytic activity toward the reduction of 4-nitrophenol.