gebhart/patrepeval huggingface dataset:
Etablierung von Tumorzelllinien und tumorassoziierten Stromazellen aus Tumorgewebe des Pankreaskarzinoms (2016)

Einleitung: Trotz intensiver Bemühungen in den letzten Jahrzenten konnte die Prognose des Pankreaskarzinoms nicht relevant verbessert werden. Differenziertere Therapieansätze müssen die Komplexität der Umgebung der epithelialen Tumorzellen wie tumorassoziierte Stromazellen (CAFs) mit einbeziehen. Des Weiteren stehen für prä-klinische in vitro Versuche weitestgehend nur etablierte Zelllinien zur Verfügung. Diese Zellen unterliegen möglicherweise Mutationen und Kreuz-Kontaminationen. Daher ist es dringend notwendig neue Zelllinien zu etablieren und CAFs der in vitro Diagnostik zugänglich zu machen.
Asymmetric photoelectron momentum distributions due to quantum interference in strong-field ionization by a few-cycle pulse (2014)

We calculate the left-right asymmetry of the photoelectron momentum distributions generated in a hydrogen atom exposed to an intense few-cycle laser pulse as a function of both the carrier-envelope phase and the laser intensity. We present results of the numerical solution of the three-dimensional time-dependent Schr\"odinger equation, semiclassical simulations accounting for both laser and Coulomb fields, and the strong-field approximation. We predict pronounced oscillations of the asymmetry parameter as a function of the intensity for a particular range of the carrier-envelope phase. In order to reveal the mechanism underlying these oscillations, we investigate in detail the electron momentum distributions in the one-dimensional case. We show that quantum interference among a large set of both bound and continuum field-free states is responsible for the oscillatory behavior of the left-right asymmetry.
Concentration Quenching of Eu3+ Fluorescence (1967)

The fluorescence quenching of the two phosphors Ba2Gd1−xEuxMe5+O6 (Me5+=Nb5+ or Ta5+) and Gd1−xEuxAl3B4O12 is reported. The shortest distance between the rare-earth sites in these materials is large and nearly equal, viz., 6.0 and 5.9 Å, respectively. The quenching behavior is different: In the materials Ba2Gd1−xEuxMe5+O6, concentration quenching occurs at x≃02, in the materials Gd1−xEuxAl3B4O12, no quenching was found under uv excitation. These results are discussed in relation to the Van Uitert—Johnson model for concentration quenching of Eu3+ fluorescence.
Idéologie et non-intervention (1988)

info:eu-repo/semantics/published
ATP protects against sepsis through macrophage P2X7 purinergic receptors by enhancing bacterial killing (INC2P.407) (2015)

Abstract Extracellular ATP binds to and signals through P2X7 receptors (P2X7R)s to modulate immune function in both inflammasome-dependent and independent manners. We show here using P2X7-/- mice as well as pharmacological receptor and channel ligands that ATP release through connexin/pannexin channels and subsequent P2X7R activation are crucial for the control of mortality, bacterial dissemination and inflammation following sepsis induced by cecal ligation and puncture. Our results with P2X7-/- bone-marrow chimeras, adoptive transfer of macrophages, and myeloid-specific P2X7-/- mice indicate that P2X7R signaling on macrophages is required for the protective effect of P2X7Rs. P2X7R signaling protects through enhancing bacterial killing by macrophages, but independently of the inflammasome. In summary, targeting P2X7Rs provides a new opportunity for harnessing an endogenous protective immune mechanism in the therapy of sepsis.
Hilbert-Huang transform: Preliminary studies in epilepsy and cardiac arrhythmias (2008)

This work describes a preliminary study based on a time-frequency analysis tool, the Hilbert-Huang transform, which can be applied to the analysis of signals deemed, to some degree, nonstationary and nonlinear. Through implementation in a software programming environment and testing on a sample of patient data sets, we demonstrate the potential of this technique. Its ability to naturally decompose electrical signals of both the heart (ECG) and brain (invasive EEG) into clear frequency and amplitude variations are shown. This ability is reflected in provisional results in the detection of epileptic seizures and cardiac arrhythmias.
Radiofrequency capacitive heaters: the effect of coupling medium resistivity on power absorption along a mouse leg (1993)

A capacitive radiofrequency source in conjunction with a temperature-controlled electromagnetic coupling medium has the potential of delivering uniform heating distributions in a mouse leg for experimental studies to investigate the use of hyperthermia as a treatment for cancer. The system has been adopted by a number of groups who have confirmed that uniform temperatures can be achieved in the presence of blood flow along a one-dimensional line which extends between the plates across the leg. In this paper, a simple mathematical model is presented and verified experimentally to demonstrate that parallel-plate capacitive radiofrequency heaters produce an inherent absorbed power distribution along the leg which is determined by the impedances across the loads. Hence, the thicker or thinner regions of the leg can be preferentially heated by using a coupling medium with lower or higher salinity, respectively. Uniform power absorption along the mouse leg required that the coupling medium had equivalent electrical properties to those of tissue.
Tuning forks, resonators, and beats: Demonstrations for “Project Listen Up”. (2008)

Gearing to an audience of all ages, a demonstration apparatus is presented including student versions of Hermann von Helmholtz’s tuning fork sounder, circa 1859 (where an intermittent current in an electromagnetic coil drives the tuning fork, which is located near a resonator), and Alexander Graham Bell’s tuning fork experiment, circa 1876 (where a variable resistance circuit due to a slight tuning fork contact in a conductive liquid causes a relay to vibrate at the same frequency as the fork). Using the popularity of a basic mechanical acoustical apparatus and briefly unfolding the histories behind Helmholtz combining several of his tuning fork sounders to generate vowel sounds and Bell’s first telephone, students are then given careful explanations of the demonstrations. Next, the focus shifts to well developed basic experiments that students can perform in a laboratory setting with emphasis placed on presenting the details of a carefully thought out scientific approach. “Project Listen Up” (an initiative of the Education in Acoustics Committee) hopes to develop an educational apparatus for a broad range of learners as one of their goals. [Work supported by USNA.]
3-DOF vs. 6-DOF &#x2014; Playful evaluation of complex haptic interactions (2011)

We present a haptic workspace that allows high fidelity two-handed multi-user interactions in scenarios containing a large number of dynamically simulated rigid objects and a polygon count that is only limited by the capabilities of the graphics card. Based in this workspace we present a novel multiplayer game that supports qualitative as well as quantitative evaluation of different haptic devices in demanding haptic interaction tasks.
Optimization of MACD and RSI indicators: An Empirical Study of Indian Equity Market for Profitable Investment Decisions (2015)

Technical analysis has been continuously used by traders and investors to make investment decisions in both developed and developing markets. The main important tools of technical analysis are MACD (Moving Average Convergence Divergence) and RSI (Relative Strength Index) used to determine the future trend of the stock prices. In developing market like India, use of technical analysis by investors is limited to the use of standard MACD and other indicators developed by respective technicians. The research covers the sample representing the equity stocks which are continually traded on the National Stock Exchange of India. This research is helpful to determine the applicability of MACD and RSI indicators for a Profitable investment decision making on Indian Financial Market. The main objective of the research is to identify the potential contribution of standard MACD and RSI indicators vis-à-vis optimized MACD and RSI indicators. The main hypotheses of the research is that the application of standard MACD and RSI indicators contribute to profitable investments than buy and hold strategy (Efficient Market Hypotheses). The tools of data analysis include Metastock trading simulation software and Excel Mathematical calculations. Research results indicate that the buy and hold strategy results in profitable investments than standard MACD and RSI indicators. According to the obtained results it is concluded that Optimized MACD and RSI indicators are more profitable than buy and hold strategy and Standard MACD and RSI indicators. And hence Optimized MACD and RSI indicators defy Efficient Market Hypotheses.
Transesterification in Mixtures of Poly(ethylene terephthalate) and Poly(ethylene naphthalene-2,6-dicarboxylate):  An NMR Study of Kinetics and End Group Effects (2000)

Mixtures of poly(ethylene terephthalate) and poly(ethylene naphthalene-2,6-dicarboxylate) have been transesterified at temperatures between 553 and 573 K. The partially transesterified polymers were analyzed using 1H NMR, and the rate constants for transesterification were obtained using a kinetic expression based on a second-order reversible reaction mechanism. The hydroxyl end groups have been shown to have a significant effect on the kinetics of the reaction by comparing rate constants obtained for the same polyester mixture but with hydroxyl end groups quantitatively esterified by trifluoroacetic acid. Carboxyl end groups do not have such a significant role in transesterification, and from the variation of rate constant at one temperature for a series of PET polymers with differing carboxyl to hydroxyl end groups, it appears that transesterification by direct ester−ester interchange is very small. The NMR data have also been used to calculate the randomness factor and number-average sequence length of the terephthalate sequences in the copolymer as transesterification progresses. The initially immiscible polyester mixture becomes miscible after a critical amount of transesterification takes place; no matter what reaction temperature is used, this homogenization takes place when the randomness factor has a value of 0.5. This does not correspond to completely random copolymer formation but suggests that the number-average sequence length of the terephthalate units in the copolyester is ca. 4−8.
Cloning of the dog bile salt export pump (BSEP; ABCB11) and functional comparison with the human and rat proteins (2008)

The dog bile salt export pump (BSEP; ABCB11) was cloned and expressed in a Sf9 insect cell system. The deduced amino acid sequence encodes a 1325-amino-acid protein, which shows 89.4% and 80.2% homology with human BSEP and rat Bsep, respectively. The transcript of the dog Bsep gene was detected at a high level in liver, but not other tissues, by quantitative RT-PCR. The BSEP-expressing membrane vesicles isolated from Sf9 cells exhibited saturable uptake of [(3)H]taurocholic acid with Michaelis constants (K(m)) of 33.7, 22.2 and 19.9 microM for the dog, rat and human transporters, respectively. The uptake of [(3)H]taurocholic acid by all three transporters was significantly inhibited by troglitazone, glibenclamide, and other several inhibitors, while pravastatin inhibited dog Bsep and human BSEP, but not rat Bsep at 100 microM. The IC(50) of troglitazone for dog Bsep, human BSEP, and rat Bsep were 32, 20, and 60 microM, and those of pravastatin were 441, 240 and >1,000 microM, respectively. In conclusion, while dog Bsep shows similar ATP-dependent bile acid transport characteristics to human BSEP and rat Bsep, there is a species difference in affinity for drugs such as pravastatin and troglitazone.
Role of fertilization promoting peptide FPP in modulating mammalian sperm function (1998)

Fertilization promoting peptide (FPP), structurally similar to thyrotrophin releasing hormone, is produced by the prostate gland and secreted into seminal plasma. Recent in vitro studies have provided evidence that FPP elicits biologically relevant responses in mouse, human and boar spermatozoa. In the presence of nanomolar concentrations of FPP, spermatozoa become fertilizing more quickly and then are inhibited from undergoing spontaneous acrosome loss, an event that would make them non-fertilizing. In vivo, these responses would be very important in maximizing the availability of potentially fertilizing spermatozoa. Adenosine, which can elicit the same responses as FPP, is known to modulate the adenylyl cyclase(AC)/cAMP signal transduction pathway; current evidence indicates that FPP and adenosine act via separate receptors on the same signal transduction pathway. Mouse spermatozoa are known to have adenosine receptors and a putative receptor for FPP (TCP-11) has been identified. Unlike many surface receptors, TCP-11 has no obvious transmembrane regions whereby modulation of AC could occur. Recent evidence suggests that FPP receptors may dimerize with adenosine receptors to activate the signaling pathway, with stimulatory adenosine receptors involved in the stimulation of capacitation, but inhibitory receptors involved in inhibition of spontaneous acrosome loss. These results indicate that FPP plays an important role in normal sperm function and that it might be used in new therapeutic strategies designed to alleviate some causes of sperm dysfunction.
Do onboarding programs work (2015)

Open source software systems rely on community source code contributions to fix bugs and develop new features. Unfortunately, it is often difficult to become an effective contributor on open-source projects due to the complexity of the tools required to develop and test new patches and the challenge of breaking into an already-formed social organization. To help new contributors learn their development practices, OSS projects have created on boarding programs that, for example, identify easy 'first bugs' and mentor new developers' contributions. However, we found that developers who join an organization through these programs are half as likely to transition into long-term community members than developers who do not use these programs. Measuring the impact of these programs is important, as coordinating and staffing on boarding projects is expensive. This paper examines on boarding programs employed by Mozilla and demonstrates that they are not as effective at transitioning new developers into long-term contributors as might be hoped, although developers who do succeed through these programs find them valuable.
Why Put FPGAs in your CPU socket? (2013)

Summary form only given. Ever since FPGAs were invented, there has been great interest in using them as computing devices, and with the logic densities of today's devices, many interesting functions have been shown to have significant performance and energy benefits when implemented in FPGAs. However, when an application requires the combination of a high-performance CPU and an FPGA accelerator, the effectiveness of the FPGA is highly determined by the latency and bandwidth between the CPU, the CPU memory system and the FPGA and its memory system. Putting FPGAs into the CPU socket is one way to address this issue. This talk will present the history, the advantages and disadvantages, the challenges, architectures, programming models and applications of "insocket" accelerator systems.
Structure of a gene for the human < (intermediate filaments/evolutionary conservation) (2016)

We present the structure and nucleotide se- quence of a gene encoding the human epidermal 67-kDa keratin. Three genomic clones were isolated from a X Charon 4A human genomic library by hybridization to a specific cDNA probe. One clone of 12.3 kilobase pairs was shown by R-loop, DNA sequence, and primer-extension analyses to encode an entire gene of about 6.25 kilobase pairs. Of eight identified introns, seven are located' within the region that encodes the central coiled-coil a-helical domain of the protein. Except for one intron located at the end of the region encoding this domain, these do not delineate apparent structural subdomains. The positions of five of the introns exactly coincide with the positions of introns previously reported in the hamster gene for the intermediate filament protein vimentin (Quax, W., Egberts, W. V., Hendricks, W., Quax- Jeuken, Y. & Bloemandal, H. (1983) Cell 35, 215-233). These findings suggest that the human 67-kDa keratin and vimentin genes arose from a common ancestral gene.
Dietary calcium intake and rates of bone loss in women. (1987)

We measured bone mineral density (BMD) at the midradius and lumbar spine in 106 normal women, ages 23-84 yr (61 were postmenopausal). Three to nine measurements (median, four) were made over 2.6 to 6.6 yr (mean, 4.1 yr). The correlation between calcium intake (range, 260-2,035 mg/d) and rate of change in BMD was not significant at the midradius (r = 0.06) or lumbar spine (r = 0.08), even after adjusting for age, menopausal status, and serum estrogen levels by multiple regression analysis. Women in the lower (mean, 501 mg/d) and in the upper (mean, 1,397 mg/d) quartiles of dietary intake had similar rates of change in BMD (%/yr [mean +/- SE], at midradius, -0.78 +/- 0.24 and -0.91 +/- 0.17 for lower and upper quartiles, respectively; at lumbar spine, -1.06 +/- 0.24 and 0.98 +/- 0.24). These data do not support the hypothesis that insufficient dietary calcium is a major cause of bone loss in women.
ChemInform Abstract: MERCURY IN ORGANIC CHEMISTRY. 15. A NOVEL STEREOSPECIFIC SYNTHESIS OF 1,3‐DIENES VIA ′HEAD‐TO‐TAIL′ DIMERIZATION OF ALKYNES (1978)

Abstract Alkine (I) reagieren mit Hg(II)‐ Chlorid über die Zwischenstufen (II) in Gegenwart von Pd‐Salzen zu unsymmetrischen Dimeren mit Butadienstruktur (III).
Inactivation of Bacillus subtilis on gypsum board using aerosolized chemical agents (2008)

The ability of aerosolized disinfectant agents to reach exterior and interior spaces of walls and other difficult to access areas has potential as a remediation technique for contained biological contamination. Bacillus subtilis were evaluated against aerosolized solutions of distilled water (dH 2 O, control), 0.05% chlorine dioxide (ClO 2 ), and 0.6% sodium hypochlorite (NaOCl). Bacillus subtilis endospores were inoculated onto commercially available gypsum board with paper facing. Aerosols generated from a collison nebulizer were directed into a sterile contact chamber housing the inoculated gypsum board for 4, 8, and 12 hour periods. Independent evaluations were conducted of the gypsum board where the organism B. subtilis were exposed to the aerosolized disinfectant. Treatment effects were evaluated through the collection of surface samples before and after exposures. The aerosolized 0.6% sodium hypochlorite solution was the only treatment successful in reducing the total concentration of B. subtilis. Treatment with sodium hypochlorite solution reduced B. subtilis organisms by 1.55-log after 4 h, 1.92-log after 8 h, and 2.50-log after 12 h of exposure, though the difference in log-reduction between exposure periods were not statistically significant.
Diode pumped alkali lasers (2011)

Diode pumped alkali lasers attract growing attention during the past several years because they have demonstrated potential to compete and, possibly, replace the best existing high power laser systems. In spite of the fact that an optically pumped alkali (potassium) vapor laser was first proposed by A.L. Schawlow and C.H. Townes in 1958, the intensive research and development of alkali vapor started only in 2003, when really efficient lasing in Rb and Cs vapors was demonstrated. The interest to this research was stimulated by the possibility of using efficient diode lasers for optical pumping of the alkali gain medium that promises high overall efficiency of the device. A variety of experiments on alkali lasers, including the demonstration of efficient Rb, Cs and K vapor lasers, power scaling experiments with multiple diode laser pumping sources and experiments on diode pumped alkali vapor amplifiers were performed during the past several years. In this paper we present a review of the most important achievements in high power alkali lasers research and development, discuss some problems existing in this field and future perspectives in DPAL development.
Pointillism in Plant Systems Biology: I. Proteomic Analysis of Plant Exosome-like Particles II. Amyloplast-binding Puroindoline Fusion Proteins for Recombinant Protein Expression. (2019)

Expanding upon our understanding of plant defense is critical, particularly with the perilous threats of climate change and overpopulation to our food security, health and well-being. In this study, we focused on plant defense using two distinct approaches. First, we performed a proteomic analysis of plant exosome-like nanoparticles in order to elucidate their defense related protein cargo. Secondly, we used a wheat antimicrobial protein, puroindoline, as a fusion partner for the expression of recombinant proteins in rice endosperm. Plant exosome-like nanoparticles (ELP) were isolated from fresh tomato and subjected to mass spectrometry (MS) analysis. The ELPs were compared to fresh pressed tomato juice, and the proteins that were significantly upregulated in the ELPs were analyzed for their defensive properties. Bioinformatic analysis identified 30 proteins upregulated in the ELPs, with a majority of these being involved in plant defense. Puroindoline is a protein found in soft wheat varieties. A unique feature of this protein is the presence of a tryptophan-rich domain, which causes it to localize and tether onto starch granule surfaces; a property we are seeking to exploit for recombinant protein isolation. We hypothesized that when expressed in a pin-null crop, such as rice, puroindoline along with its fusion partner will localize and adhere to starch granule surfaces. PIN fusions were expressed in rice, and their subcellular localization was determined by immunolocalization. It was observed that PIN localizes to rice starch ii granules in vitro and in planta, and retains its starch granule binding abilities as a fusion partner. To identify other possible starch granule binding fusion partners, an anhydrous cleavage method was developed that can scan dry biological materials for associated proteins, in this case the starch granule surface. Incubation of our cleavage reagent with isolated rice starch granules yielded several cleavage products as determined through SDS-PAGE. These cleavage products were compared with previous proteomic data of trypsin digested rice starch granules.
A new generation of universal contactless battery charging platform for portable consumer electronic equipment (2004)

This invention is related to a new planar inductive battery charger for portable electronic equipment such as mobile phones, palm pilots and CD players. New multilayer printed-circuit-board (PCB) winding matrices of hexagonal structures that can generate magnetic flux of almost even magnitude over the surface of the winding arrays have been developed. The new concept forms the basis for a new generation of universal charging platform for a wide range of portable electronic equipment. Different types of portable electronic equipment can be placed and charged simultaneously on the charging platform, regardless of their positions and orientation. The principle and structure of the charging platform are explained and the feasibility has been confirmed with practical measurements. The proposed universal charging platform has been successfully used for mobile phones, MP3 players and electronic dictionaries.