gebhart/patrepeval huggingface dataset:
Geography and location are the primary drivers of office microbiome composition (2016)

North Americans spend the majority of their time indoors where they are exposed to the microbiome of the built environment (BE) they inhabit. Despite the ubiquity of microbes in BEs, and their potential impacts on health and building materials, basic questions about the microbiology of these environments remain unanswered. We present a study on the impacts of geography, material type, human interaction, location in a room, seasonal variation, and indoor and microenvironmental parameters on bacterial communities in offices. Our data elucidates several important features of microbial communities in BEs. First, under normal office environmental conditions, bacterial communities do not differ based on surface material (e.g., ceiling tile or carpet), but do differ based on the location in a room (e.g., ceiling or floor), two features which are often conflated, but which we are able to separate here. We suspect that previous work showing differences in bacterial composition with surface material were likely detecting differences based on different usage patterns. Next, we find that offices have city-specific bacterial communities, such that we can accurately predict which city an office microbiome sample is derived from, but office-specific bacterial communities are less apparent. This differs from previous work which has suggested office-specific compositions of bacterial communities. We again suspect that the difference from prior work arises from different usage patterns. As has been previously shown, we observe that human skin contributes heavily to the composition of BE surfaces. Our study highlights several points that should impact the design of future studies of the microbiology of the BEs. First, projects tracking changes to BE bacterial communities should focus sampling effort on surveying different locations in offices and in different cities, but not necessarily different materials or different offices in the same city. Next, disturbance due to repeat sampling, though detectable, is small compared to other variables, opening up a range of longitudinal study designs in the built environment. Next, studies requiring more samples than can be sequenced on a single sequencing run (which is increasingly common) must control for run effects by including some of the same samples on all sequencing runs as technical replicates. Finally, detailed tracking of indoor and material environment covariates is likely not essential for BE microbiome studies, as the normal range of indoor environmental conditions is likely not large enough to impact bacterial communities.
Optical nanofibers interfacing cold toms. A tool for quantum optics (2016)

We built a new experiment using cold atoms interacting with the light guided by an optical nanofiber. We first developed a nanofiber manufacturing bench. By heating and stretching a commercial optical fiber, a silica cylinder of 400 nm diameter is obtained. The light guided in these nanofibers is strongly focused over the whole length and exhibits strong evanescent fields. We then prepared a vacuum chamber and the laser system necessary for the manipulation of cold atoms. After inserting a nanofiber amid a cloud of cold atoms, we observed the phenomenon of slow light under the conditions of electromagnetically induced transparency: the light guided by the fiber is slowed down to a speed 3000 times smaller than its usual speed. We also stored the light guided by an optical fiber. After several microseconds, the information stored as a collective atomic excitation could be retrieved in the fiber. We have shown that this optical memory works for light pulses containing less than one photon on average. This system may therefore be used as a quantum memory, an essential tool for future quantum communication networks. Finally, we trapped atoms in an array in the vicinity of the nanofiber thanks to the light guided by the latter. Compared to our first set of experiments, the resulting cloud has a longer lifetime (25 ms) and interacts more strongly with the guided light (OD ~ 100). This new system should allow to efficiently implement other quantum optics protocols, such as the generation of single photons, or the entanglement of two remote atomic ensembles.
Gene duplication can generate “whole gene” and “chimeric gene” paralogs. (2015)

&lt;p&gt;(a) When unequal crossing-over (denoted with an “X”) occurs within the intergenic region between two paralogs, one chromosome gains an extra copy of a paralog, while the other chromosome loses one of the paralogs. This is followed by divergence of each paralog (only shown for the chromosome that gained a paralog and denoted as shift in color). A similar process can lead to the creation of the original paralog duplication, if, for example, transposons generate regions of sequence similarity on either side of a gene, thus enabling unequal crossing-over (not shown). (b) The same process can also lead to a chimeric gene duplicate if the crossing over occurs within the intragenic region (most likely within an intronic region).&lt;/p&gt;
Metal-Supported Perovskite as an Efficient Bifunctional Electrocatalyst for Oxygen Reduction and Evolution: Substrate Effect (2021)

Due to increased energy demand and environmental concerns, sustainable energy systems such as electrolyzers and Li-air batteries have attracted significant interest. However, it is imperative to develop an efficient inexpensive catalyst for the underlying reactions, namely oxygen reduction (ORR) and evolution (OER) reactions, to overcome their sluggish kinetics. In our previous work, a combination of silver and Co 3 O 4 particles showed high bifunctional activity. Herein, we extend the study to investigate how the electrocatalytic activity is dependent on the oxide composition and the type of the underlaying substrate. A significant enhancement in OER performance is realized at perovskite-supported silver or gold electrodes with activity decreasing in the order Ag≥Au&gt;GC. This is attributed mainly to a synergistic interaction between the oxide and metal support and the enhanced conductivity. The ORR activity observed at oxides loaded on Ag and Au bulk electrode is similar, however they exhibit about 450 mV lower overpotential than on GC. The improved activity at oxides/metal substrate renders this approach promising for O 2 -electrodes design.
Economic viability of application of FACTS devices for reducing generating costs (2010)

the multifunctional capabilities of Flexible AC Transmission System (FACTS) devices paved new paths for controlling and enhancing the power transfer and usable capacity of transmission lines. The ability to enhance power transfers lead to their applications in a multi machine power system for the purpose of an overall reduction in power generation cost, among the others. The study presented in this paper deals with evaluation of economic viability of application of FACTS devices for generation cost reduction. It starts with optimal placement of four types of FACTS devices, namely Static Var compensator (SVC), Thyristor-Controlled Series Capacitor (TCSC), Thyristor-Controlled Voltage Regulator (TCVR), and Thyristor-Controlled Phase Shifting Transformer (TCPST) in a multi machine power system. The allocation methodology accounts for the cost of generated active and reactive powers, load growth, and cost of selected FACTS devices over a wide range of operating conditions. The allocation task is handled by the Optimal Power Flow (OPF) and Genetic Algorithm (GA) based optimization procedures. The economic viability of the solution is assessed using Net Present Value (NPV) calculation. Finally, Tornado diagram is used to assess sensitivity of the solution to various parameters involved in the optimization procedure.
Overview of the 2nd Author Profiling Task at PAN 2014 (2013)

Abstract This overview presents the framework and the results for the Author Profiling task at PAN 2014. Objective of this year is the analysis of the adapt-ability of the detection approaches when given different genres. For this purpose a corpus with four different parts (subcorpora) has been compiled: social me-dia, Twitter, blogs, and hotel reviews. The construction of the Twitter subcorpus happened in cooperation with RepLab in order to investigate also a reputational perspective. Altogether, the approaches of 10 participants are evaluated. 1
Optical WDM regeneration: status and future prospects (2009)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text L. Provost, P. Petropoulos, and D. J. Richardson, "Optical WDM regeneration: status and future prospects," in Optical Fiber Communication Conference and National Fiber Optic Engineers Conference, OSA Technical Digest (CD) (Optica Publishing Group, 2009), paper OWD7. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Detrimental effects of thyroid hormone analog DITPA in the mouse heart: increased mortality with in vivo acute myocardial ischemia-reperfusion (2010)

There is emerging evidence that treatment with thyroid hormone (TH) can improve postischemic cardiac function. 3,5-Diiodothyropropionic acid (DITPA), a TH analog, has been proposed to be a safer therapeutic agent than TH because of its negligible effects on cardiac metabolism and heart rate. However, conflicting results have been reported for the cardiac effects of DITPA. Importantly, recent clinical trials demonstrated no symptomatic benefit in patients with DITPA despite some improved hemodynamic and metabolic parameters. To address these issues, dose-dependent effects of DITPA were investigated in mice for baseline cardiovascular effects and postischemic myocardial function and/or salvage. Mice were treated with subcutaneous DITPA at 0.937, 1.875, 3.75, or 7.5 mg·kg(-1)·day(-1) for 7 days, and the results were compared with untreated mice for ex vivo and/or in vivo myocardial ischemia-reperfusion (I/R). DITPA had no effects on baseline body temperature, body weight, or heart rate; however, it mildly increased blood pressure. In isolated hearts, baseline contractile function was significantly impaired in DITPA-pretreated mice; however, postischemic recovery was comparable between untreated and DITPA-treated groups. In vivo baseline cardiac parameters were significantly affected by DITPA, with increased ventricular dimensions and decreased contractile function. Importantly, DITPA-treated mice demonstrated high prevalence of fatal cardiac rhythm abnormalities during in vivo ischemia and/or reperfusion. There were no improvements in myocardial infarction and postischemic fractional shortening with DITPA. Myocardial sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA), phospholamban (PLB), and heat shock protein (HSP) levels remained unchanged with DITPA treatment. Thus DITPA administration impairs baseline cardiac parameters in mice and can be fatal during in vivo acute myocardial I/R.
Message from the Chairs of SEAMS 2019 (2019)

The following topics are dealt with: adaptive systems; learning (artificial intelligence); security of data; cyber-physical systems; Internet; Internet of Things; Pareto optimisation; control engineering computing; software engineering; artificial intelligence.
Supplementary Table 1 from A Phase II, Randomized, Placebo-Controlled Study of Vismodegib as Maintenance Therapy in Patients with Ovarian Cancer in Second or Third Complete Remission (2023)

&lt;p&gt;PDF file - 61K, Primer/probes used for qRT-PCR profiling of Hedgehog (Hh) pathway genes. A table highlighting the primers and probes used for qRT-PCR profiling.&lt;/p&gt;
Tachycardia in the Presence of Ventricular Pacing (2019)

A 61-year-old man with coronary artery disease presented with volume overload caused by medication noncompliance. His medical history included percutaneous coronary intervention; ischemic cardiomyopathy (left ventricular [LV] ejection fraction, <0.15); and placement of a biventricular implantable cardioverter-defibrillator (ICD), model and programming unknown. Chest radiographs showed properly positioned ventricular and right atrial leads. Figure 1 shows the patient's electrocardiogram (ECG) on presentation.On the basis of the ECG, what is the patient's diagnosis?A) Supraventricular tachycardia with biventricular pacing response.The ECG shows a relatively narrow QRS complex at a ventricular rate of 100 beats/min. Notably, an rSR' configuration in leads V1 and V2 (Fig. 2A, arrows) represents a retrograde P wave that suggests supraventricular tachycardia—most likely atrioventricular nodal reentry tachycardia, not sinus tachycardia with normal atrioventricular delay programming.1 The ventricular pacemaker stimuli after each intrinsic QRS complex are probably from responsive biventricular ICD pacing. After the patient's tachycardia resolved, we observed sinus rhythm, normal right bundle branch configuration, and normal biventricular pacing (Fig. 2B).When the ICD senses intrinsic activity in one ventricle, it immediately paces the other ventricle, to better synchronize LV contraction. However, the initially narrower QRS configuration suggests that the LV pacing stimuli were not capturing the already depolarized ventricular myocardium. Responsive biventricular ICD pacing is expected to produce fusion complex morphology, as in cardiac resynchronization therapy, and indeed the wider QRS complex after conversion to sinus rhythm indicates fusion from His–Purkinje system depolarization with coinciding pacing stimuli.In Figure 1, the response is not antitachycardia pacing, because the pacing stimuli occur before the QRS complexes; moreover, there was no burst of pacing stimuli faster than the spontaneous rate.1 Nor is the response pacemaker-mediated tachycardia, because the pacing stimuli occur after the QRS complexes begin.2,3 The P waves at the end of the QRS complexes might be retrograde conduction from the pacemaker stimulus; however, the very long subsequent PR intervals suggest another mechanism.
The Bouguer‐Beer‐Lambert Law: Shining Light on the Obscure (2020)

Abstract The front cover artwork is provided by the group of Jürgen Popp at the Friedrich Schiller University Jena and the Leibniz Institute of Photonic Technology. The image allegorizes the complex correlations in which the Bouguer‐Beer‐Lambert law is interleaved with Maxwell's equations and dispersion theory. Read the full text of the Review at 10.1002/cphc.202000464 .
Acoustic Properties of a Two-Mass Model of the Vocal Cords (1972)

The acoustic theory of a two-mass model of the vocal cords is outlined. An interactive DDP-516 laboratory computer is used to implement the vocal-cord model and a coupled vocal tract. The digital simulation shows the two-mass model to correspond in acoustic behavior to observations made on human vocal cords. Realistic results are obtained for fundamental frequency of vibration, duty factor, waveform of glottal volume velocity, source-system interaction, and dependence upon subglotta1 pressure, cord tension, and phonation-neutral area.
The effect of activated protein C on fibrinolysis in cell-free plasma can be attributed specifically to attenuation of prothrombin activation. (1993)

The effect of human activated protein C (APC) on tissue plasminogen activator (tPA)-induced fibrinolysis was studied in cell free plasma and in a system of purified components. Clots were produced by adding plasma or a solution of fibrinogen and plasminogen to the wells of a microtiter plate containing small separated aliquots of Ca2+, thrombin, and tPA, plus and minus APC. Initial clotting and subsequent fibrinolysis were monitored continuously by turbidity. The lysis time of dialyzed normal human plasma (NHP) was longer than that of dialyzed barium citrate-adsorbed plasma (BAP). APC had no effect on the lysis time of BAP but shortened the lysis time of NHP to that of BAP. Two fractions were produced from material eluted from the barium citrate pellet by precipitation of selective components with polyethylene glycol 8000 (PEG). One fraction comprised materials which precipitated at 5% PEG (5% PF) and the other materials which precipitated between 5 and 40% PEG (5-40% PF). Both fractions together, but neither alone, prolonged the lysis time of BAP, an effect which could be reversed by APC. Fractionation of the 5% PF showed that the component with the required activity has properties of the procoagulant surface and can be replaced with vesicles of phosphatidylcholine/phosphatidylserine (PCPS). In addition, the 5-40% PF can be replaced with either the combination of purified coagulation Factors II, IX, and X or Factor II plus the prothrombin activator Factor Xa. When Factor Xa was used as the activator in BAP plus PSPC vesicles, a dose-dependent saturable increase in lysis time was observed with a half-maximal increase occurring at 32 pM Factor Xa. This effect was eliminated by APC. In a system of purified components comprising PCPS vesicles, Factors V and II, protein S, plasminogen and fibrinogen; the prothrombin activators Factor Xa and ecarin both induced a prolongation of the lysis time. APC prevented prolongation by Factor Xa but not by ecarin. The time courses of the generation of thrombin and plasmin during fibrinolysis of clots produced from systems of purified components in the presence and absence of APC, and with Factor Xa as the prothrombin activator, were determined by standardized activity assays using chromogenic substrates. In the absence of APC the lysis time was 145 min, and prothrombin was quantitatively converted to thrombin. In the presence of APC, however, the lysis time was reduced to 100 min with no evidence for the activation of prothrombin.(ABSTRACT TRUNCATED AT 400 WORDS)
Analysis of Coupling Slots with a Reflection-canceling Wall for Parallel Plate Slot Array Antenna (2019)

A center-feed parallel plate slot array antenna with hard walls which supports a TEM wave is proposed for millimeter wave application. Coupling slots of the feeder network are analyzed and designed by method of moment (MoM). It is shown that computation time by using MoM is drastically reduced compared to HFSS. The design parameter relationship between HFSS and MoM models is found for compensating the inaccuracy caused by simplified assumption in the MoM model.
Visible, near infrared spectropolarimeter for characterization of the DKIST optical system and polarization properties (Conference Presentation) (2017)

We have developed a laboratory spectropolarimeter built to characterize the transmissive and reflective polarization properties of the Daniel K. Inouye Solar Telescope (DKIST) optical components. This includes the full Mueller matrix of retarders, polarizers, mirrors, dichroic coatings, and other optical elements that introduce polarization effects. Characterization is performed at various angles of incidence from 400nm to 1650nm with ~9nm spectral resolution and statistical noise limits >5000 using many automated stages. With this data set, we present tolerance analysis of typical as-built DKIST optics.
CDK12-Mutated Prostate Cancer: Clinical Outcomes With Standard Therapies and Immune Checkpoint Blockade (2020)

<i>CDK12</i> mutations define an aggressive prostate cancer subgroup, with a high rate of metastases and short overall survival. CPI may be effective in a minority of these patients, and exploratory analysis supports using anti-programmed cell death protein 1 drugs early. Prospective studies testing CPI in this subset of patients with prostate cancer are warranted.
2A1-F11 Contact model between a finger and ball for robot throwing (2007)

In this paper, we investigate a ball pitching motion as one of human's dexterous object manipulations. We present a contact model between a robot finger and a ball, and calculate the driving force of the finger for obtaining a desired direction, velocity, and angular velocity of the ball.
Electromagnetically induced transparency in a RF discharge (1998)

\n We report on electromagnetically induced transparency in a \nradio-frequency \ndischarge of metastable helium atoms. We show that a large effect can be \nobserved in spite of the discharge regime needed to produce the metastable \nhelium and in spite of its Zeeman degeneracy. We discuss the mechanism and the \nconditions for the observation of such a phenomenon in a helium discharge.\n\n\n \n\n
Queue machines: hardware compilation in hardware (2003)

In this paper we hypothesize that reconfigurable computing is not more widely used because of the logistical difficulties caused by the close coupling of applications and hardware platforms. As an alternative, we propose computing machines that use a single, serial instruction representation for the entire reconfigurable computing application. We show how it is possible to convert, at runtime, the parallel portions of the application into a spatial representation suitable for execution on a reconfigurable fabric. The conversion to spatial representation is facilitated by the use of an instruction set architecture based on an operand queue. We describe techniques to generate code for queue machines and hardware virtualization techniques necessary to allow any application to execute on any platform.
Plasma Biomarkers of Insulin and the Insulin-like Growth Factor Axis, and Risk of Colorectal Adenoma and Serrated Polyp (2019)

A higher plasma level of IGFBP1 was associated with lower risk of serrated polyp. Our findings support a potential role of IGFBP1 in the serrated pathway of CRC in women.
Analysis of the LKB1-STRAD-MO25 complex (2004)

Mutations in the LKB1 tumour suppressor threonine kinase cause the inherited Peutz-Jeghers cancer syndrome and are also observed in some sporadic cancers. Recent work indicates that LKB1 exerts effects on metabolism, polarity and proliferation by phosphorylating and activating protein kinases belonging to the AMPK subfamily. In vivo, LKB1 forms a complex with STRAD, an inactive pseudokinase, and MO25, an armadillo repeat scaffolding-like protein. Binding of LKB1 to STRAD-MO25 activates LKB1 and re-localises it from the nucleus to the cytoplasm. To learn more about the inherent properties of the LKB1-STRAD-MO25 complex, we first investigated the activity of 34 point mutants of LKB1 found in human cancers and their ability to interact with STRAD and MO25. Interestingly, 12 of these mutants failed to interact with STRAD-MO25. Performing mutagenesis analysis, we defined two binding sites located on opposite surfaces of MO25alpha, which are required for the assembly of MO25alpha into a complex with STRADalpha and LKB1. In addition, we demonstrate that LKB1 does not require phosphorylation of its own T-loop to be activated by STRADalpha-MO25alpha, and discuss the possibility that this unusual mechanism of regulation arises from LKB1 functioning as an upstream kinase. Finally, we establish that STRADalpha, despite being catalytically inactive, is still capable of binding ATP with high affinity, but that this is not required for activation of LKB1. Taken together, our findings reinforce the functional importance of the binding of LKB1 to STRAD, and provide a greater understanding of the mechanism by which LKB1 is regulated and activated through its interaction with STRAD and MO25.