gebhart/patrepeval huggingface dataset:
Simulación del lenguaje ensamblador de un procesador RISC: Windeluxe (1996)

El siguiente trabajo consiste en la implementacion de un simulador del lenguaje ensamblador del procesador RISC hipotetico DLX, descrito en [1]. El objetivo es conseguir un entorno amigable de programacion para un lenguajes de bajo nivel, como es un ensamblador, y enfocarlo hacia un campo puramente didactico, como una herramienta de introduccion al aprendizaje de un ensamblador RISC, mas sencillo que el de un procesador CISC en cuanto a su repertorio de instrucciones. Con el fin de facilitar la interaccion con el usuario y la programacion se ha realizado ademas una extension del repertorio original de instrucciones. Por otra parte, la estructura del simulador es muy modular con el fin de que se puedan modificar y ampliar partes del mismo de forma sencilla.
ChemInform Abstract: FULLY ACTIVE INSULIN BY SELECTIVE FORMATION OF DISULFIDE BRIDGES BETWEEN SYNTHETIC A‐CHAINS AND NATURAL B‐CHAINS (1979)

Abstract Durch Kondensation von 3 entsprechenden Fragmenten, von denen zwei (Sequenzen 4‐14 und 15‐21) am polymeren Träger schrittweise aufgebaut werden, wird zunächst eine Insulin‐A‐Kette (I) synthetisiert, die selektiv abspaltbare S‐Schutzgruppen enthält.
Disturbance rejection of real power flow by grid-tied inverter (2017)

High penetration of distributed and renewable power generation systems challenges the conventional paradigm of stabilizing power systems with the standard rotational inertia used in power generation. To improve the stability of a power system, advanced disturbance rejection control techniques can be used to provide damping and power disturbance mitigation. An approach for three-phase (real) power disturbance mitigation using real-time feedback control is outlined in this paper. The control algorithm for power disturbance rejection is formulated via the internal model principle, computed via minimum variance control and designed to operate with a commercial grid-tied inverter. The end result is a real-time controlled inverter that is able to reduce power disturbances created by unanticipated load changes in an electrical grid. An experimental setup is used to validate the proposed control algorithm through on/off switching of a dynamic load and the results illustrate the feasibility of the proposed controller for real-time mitigation of power flow oscillations.
Improved Light Output Power of GaN-Based Light Emitting Diodes by Enhancing Current Spreading Using Single-Wall Carbon Nanotubes (2009)

Single-wall carbon nanotubes (SWCNTs) have been combined with indium tin oxide (ITO) to improve the output power of GaN-based light emitting diodes (LEDs). LEDs fabricated with the SWCNT/ITO contacts give a forward voltage of 3.61 V at 350 mA, which is slightly higher than that of LEDs with ITO-only contacts. The SWCNT/ITO and ITO-only contacts produce transmittance values of 91.5 and 94.4% at 460 nm, respectively. However, LEDs with SWCNTs show a higher output power by 60% at 20 mA compared to those without SWCNTs. Photoemission microscope analyses show that the well-dispersed SWCNT bundle efficiently serves as a current spreader.
Subglottic Stenosis Examined as a Fibrotic Response to Airway Injury Characterized by Altered Mucosal Fibroblast Activity (2010)

Subglottic stenosis represents a fibrotic airway repair process that involves fibroblasts that produce recurrent, excessive scar formation. We suggest that SGS development and recurrence may be partially dictated by altered fibroblast responsiveness to antifibroplastic signals during mucosal repair.
DNA-intercalation on pyrene modified surface coatings (2005)

Utilising the strong affinity between nucleic acids and an intercalating pyrene derivate, a novel efficient method for unspecific immobilisation of double-stranded DNA on to solid support for applications in bioanalytic, biophysics and microbiology is presented.
Introduction to nonlinear science (1996)

Preface 1. Nonlinear behavior in the physical sciences and biology: some typical examples 2. Quantitative formulation 3. Dynamical systems with a finite number of degrees of freedom 4. Linear stability analysis of fixed points 5. Nonlinear behavior around fixed points: bifurcation analysis 6. Spatially distributed systems, broken symmetries, pattern formation 7. Chaotic dynamics Appendices References Index.
Difference in Outcome of Adolescents with Acute Lymphoblastic Leukemia (ALL) Enrolled in Pediatric (AIEOP) and Adult (GIMEMA) Protocols. (2004)

Abstract Progress in the treatment of acute lymphoblastic leukaemia (ALL) has led to better survival rates; however, children have had a greater benefit from improved treatment modalities than adolescent who show an overall lower event-free survival (EFS) compared to younger patients. Some differences in the clinical and biologic characteristics of adolescents compared to childhood ALL may partly account for the different outcome, but adolescents treated on pediatric ALL trials seem to have a significantly better EFS than those treated on adult trials. We retrospectively compared the results obtained in a series of 245 patients ranging in age from 14 to 18 years diagnosed and enrolled in specific Italian children and adult ALL trials, between 4/1996 and 10/2003. One hundred and fifty patients, from 30 pediatric centers, underwent the childhood AIEOP ALL 95 and 2000 protocols; the other 95, from 28 adult centers, were enrolled in the GIMEMA ALL 0496 and 2000 protocols. The AIEOP 95 and 2000 trials are BFM-like protocols with a 7 drug induction followed by risk-modulated post-remission therapy that includes high-dose MTX and reinduction for low and intermediate groups, and intensive blocks (high-dose MTX and cytarabine) for high-risk patients. Standard maintenance therapy is administered up to a total of 2 years. Cranial radiotherapy is limited to high-risk patients. Stem cell transplantation is planned for very high-risk patients. The GIMEMA regimens are instead based on an induction with high-dose anthracyclines (cumulative dose 550 mg/m2), high-dose cytarabine as consolidation and do not include high-dose MTX and the reinduction phase. Standard maintenance with vincristine + daunorubicin/cyclophosphamide pulses is given for 2 years. Cranial radiotherapy is administered to all patients. The main patients characteristics at diagnosis, in the two groups under examination, were comparable except for age: median age was 15 and 16 years, respectively in the AIEOP and GIMEMA trials.Poor risk cytogenetic translocations and T-immunophenotype were equally dinstributed. Adolescents in the AIEOP protocols had a higher CR rate (94% vs 89%) and a lower relapse rate (17% vs 45%) compared to the adolescents enrolled in the GIMEMA trials. The 2-year overall survival rate was 80% in the AIEOP protocols and 71% in the GIMEMA trials. Detailed results according to the different clinical and biologic features of the adolescents analyzed will be presented. The results of our comparative study indicate that adolescents enrolled in pediatric trials have a more favourable clinical outcome.
Layer-by-Layer Assembly of TiO<SUB>2</SUB> Nanoparticles for Stable Hydrophilic Biocompatible Coatings (2005)

Stable, super-hydrophilic (water contact angle approximately equal to 0 degrees) titanium dioxide nanoparticle thin films have been obtained on substrates with different initial wettability such as glass, poly(methyl methacrylate) and poly(dimethyl siloxane) using layer-by-layer nano-assembly method. Titanium dioxide nanoparticles were alternated with poly(styrene sulfonate) to form films of thickness ranging from 11 nm to 220 nm. The hydrophilicity of these thin films increases with increasing number of deposited PSS/TiO2 bilayers. It was found that 2, 5 and 20 layers were needed to form super-hydrophilic TiO2 coating on glass, PMMA and PDMS respectively. Oxygen plasma treatment of substrate surfaces enhanced the formation of homogeneous TiO2 films and accelerated the formation of hydrophilic layers. Super-hydrophilicity has been shown to be unique to PSS/TiO2 films as compared with other polyelectrolyte/nanoparticle layers, and UV irradiation may restore hydrophilicity even after months of storing of the samples. Biocompatibility of TiO2 nanoparticle films has been demonstrated by the successful cell culture of human dermal fibroblast.
Correlation of Subatmospheric Pressure, Saturated, Pool Boiling of Water on a Structured-Porous Surface (2011)

Saturated pool-boiling experiments at 1 atm and subatmospheric pressure assess the utility of fine-filament screen-laminate enhanced surfaces as effective bubble nucleation sites. Experiments were conducted on vertically oriented, multilayer laminates in saturated distilled water at pressures of 0.2–1.0 atm. The performance of 12 different copper-filament surfaces, having pore hydraulic diameters ranging from 14 μm to 172 μm, is documented. Experimental results show that boiling performance is a strong function of screen-laminate geometry. In the present work, enhancement of up to 27 times that of an unenhanced surface was obtained at a superheat of 8 K and a pressure of 0.2 atm. Dimensional analysis and multiparameter regression are used to develop a heat transfer correlation that relates the boiling heat transfer coefficient to the lamination geometry.
A laryngoscope for office-based imaging of human vocal folds using OCT (2009)

We developed a laryngoscope with an integrated OCT beam path for office-based non-contact imaging of human vocal folds. In combination with conventional videolaryngoscopy superficial and subsurface lesions can be detected. For error-free interpretation of OCT images obtained in office-based examination motion artifacts have to be considered. To demonstrate the implications on OCT images we simulated probe and patient movements for different commercial systems representing the three OCT modalities and analyzed the OCT data. Our results show that time domain and fourier domain OCT with a swept light source are probably better suited for noncontact imaging of awake patients than the current generation of fourier domain OCT engines with spectrometer design.
Power Station Abnormal Data Cleaning Method Based On Big Data Mining (2021)

It’s easy to confuse “dirty data” and equipment fault state points in the process of massive data cleaning of power station, resulting in miscleaning. Based on this, a combined anomaly parameter cleaning method based on big data mining, DBSCAN algorithm and improved Gaussian kernel correlation vector machine is proposed. Firstly, the association degree between parameters is quantified by big data mining to find the combination of strong association parameters. Then the abnormal points are detected by DBSCAN algorithm, and the abnormal data determination process combined with correlation parameters is given. Finally, the improved Gaussian kernel correlation vector machine is used to predict and repair the abnormal data. The case results show that the improved method can accurately distinguish “dirty data” from equipment fault state points, and the improved model takes less time while ensuring the prediction accuracy.
Transfer Cells in Roots of Phaseolus coccineus: Ultrastructure and Possible Function in Exclusion of Sodium from the Shoot (1977)

A study was made of ultrastructural aspects and ion distribution in roots of Phaseolus coccineus as affected by NaCl and Na2SO4 salinity. In the proximal region of the root, xylem parenchyma cells are differentiated as transfer cells with well developed wall protuberances adjacent to the half-bordered pits of the vessels. The cytoplasm of these transfer cells contains cisternae of rough endoplasmic reticulum, the number of which was increased greatly when the plants were grown in the presence of NaCl or Na2SO4. The cisternae of the endoplasmic reticulum are often associated closely with the plasmalemma and interconnected with it by fibrillar bridges. Wall protuberances occur also in the exodermis and epidermis of the more apical region of the root. Their function is still unknown. P. coccineus excludes Na, but not Cl, from the leaves by retaining it particularly in the proximal region of the root. X-ray microanalysis of unfixed, frozen, hydrated specimens revealed that the transfer cell-type xylem parenchyma cells in salt-treated roots accumulated Na relative to both the adjoining xylem vessels and the cortical cells and showed very high Na/K and Na/Cl ratios. It is suggested that the xylem parenchyma cells can reabsorb Na from the vessels, probably in exchange for K, and that Na exclusion from the shoot is at least partly mediated by this process. The implication of this for regulation of salt transport in salt sensitive glycophytes is discussed.
Structural modification of H2-receptor antagonists provide post-H2-receptor gastric antisecretory activity. (1987)

Structural analogues (e.g., Wy-46,499) of a known H2-antagonist (Wy-45,662) were found to inhibit acid secretion in the pylorus ligated rat and to block forskolin and DBcAMP-stimulated [14C]amino-pyrine (AP) uptake by rat isolated gastric mucosal cell preparations. Wy-45,662 (N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]thieno [3,4- d]isothiazol-3-amine 1, 1-dioxide), a very potent histamine H2-antagonist and antisecretory agent in the rat (ED50 approximately equal to 0.3 mg/kg), had no effect in vitro at 1 microM on forskolin-induced [14C]AP uptake while 10 nM Wy-45,662 completely suppressed histamine-stimulated [14C]AP uptake. In contrast, the N-benzylated form of Wy-45,662, Wy-46,499, dose-dependently (1 X 10(-7) -3 X 10(-6)M) suppressed forskolin-stimulated [14C]AP uptake while retaining modest antisecretory activity (ED50 approximately equal to 8 mg/kg) in vivo. Wy-46,499's modest antisecretory activity was thus attributable to inhibition via a post-histamine H2-receptor mechanism.
A new synthesis of substituted fulvenes (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA new synthesis of substituted fulvenesGary C. M. Lee, Brian Tobias, Judy M. Holmes, Dale A. Harcourt, and Michael E. GarstCite this: J. Am. Chem. Soc. 1990, 112, 25, 9330–9336Publication Date (Print):December 1, 1990Publication History Published online1 May 2002Published inissue 1 December 1990https://pubs.acs.org/doi/10.1021/ja00181a039https://doi.org/10.1021/ja00181a039research-articleACS PublicationsRequest reuse permissionsArticle Views1312Altmetric-Citations88LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Genotypic Susceptibility Scores and HIV Type 1 RNA Responses in Treatment-Experienced Subjects with HIV Type 1 Infection (2020)

This study compared the role of genotypic susceptibility scores (GSS) as a predictor of virologic response in a group (n = 234) of HIV-infected, protease inhibitor (PI)-experienced subjects. Two scoring methods [discrete genotypic susceptibility score (dGSS) and continuous genotypic susceptibility score (cGSS)] were developed. Each drug in the subject's regimen was given a binary susceptibility score using Stanford inferred drug resistance scores to calculate the dGSS. In contrast to the dGSS, the cGSS model was designed to reflect partial susceptibility to a drug. Both GSS were independent predictors of week 16 virologic response. We also compared the GSS to a phenotypic susceptibility score (PSS) model on a subset of subjects that had both GSS and PSS performed, and found that both models were predictive of virologic response. Genotypic analyses at enrollment showed that subjects who were virologic nonresponders at week 16 revealed enrichment of several mutated codons associated with nucleoside reverse transcriptase inhibitors (NRTI) (codons 67, 69, 70, 118, 215, and 219) or PI resistance (codons 10, 24, 71, 73, and 88) compared to subjects who were virologic responders. Regression analyses revealed that protease mutations at codons 24 and 90 were most predictive of poor virologic response, whereas mutations at 82 were associated with enhanced virologic response. Certain NNRTI-associated mutations, such as K103N, were rapidly selected in the absence of NRTIs. These data indicate that GSS may be a useful tool in selecting drug regimens in HIV-1-infected subjects to maximize virologic response and improve treatment outcomes.
Prognostic and predictive value of tumor-infiltrating lymphocytes for clinical therapeutic research in patients with non-small cell lung cancer (2016)

Our findings support the hypothesis that TILs could be a prognostic marker in NSCLC. High-quality randomized studies are needed to verify statistically the effect of TILs on prognosis in future research.
Mosaic paternal haploidy in a patient with pancreatoblastoma and Beckwith–Wiedemann spectrum (2019)

Pancreatoblastoma is a rare type of pancreatic cancer in children. Here, we describe a case in which Beckwith-Wiedemann syndrome (BWS) was first suspected because of placental mesenchymal dysplasia. Although the baby did not show the stigmata characteristic of BWS or abnormal peripheral blood methylation, she developed a massive pancreatoblastoma 2 months later. She survived after partial excision of the tumor and chemotherapy. The methylation pattern of the pancreatoblastoma tissue was typical of BWS. Single nucleotide polymorphism (SNP) array analyzes revealed that the pancreatoblastoma tissue had genome-wide loss of maternal alleles. Peripheral blood and nontumor pancreatic tissue showed normal biparental genomic contribution. Interphase fluorescence in situ hybridization analysis with centromeric probes for chromosomes 2 and 11 revealed haploid pancreatoblastoma cells, whereas the placental mesenchymal dysplasia tissue and nontumor pancreas tissue showed diploidy. SNP genotype analysis suggested the presence of mosaicism with the pancreatoblastoma tissue having a different paternal haplotype than that of the peripheral blood and nontumor pancreatic tissue. We report for the first time mosaic paternal haploidy associated with pancreatoblastoma. Babies with placental mesenchymal dysplasia, even those without a definitive diagnosis of BWS, need to be closely followed for the occurrence of embryonic tumors.
Linear Precoding Based On A Stochastic Mse Criterion (2005)

Publication in the conference proceedings of EUSIPCO, Antalya, Turkey, 2005
Development of Pattern Recognition Algorithms for Identification of Gut Microorganisms using Fatty Acid Signatures (2012)

A pattern recognition algorithm was developed that was capable of accurately identifying the presence of specific microbial species in gut samples from the sample's composite fatty acid signature. We focused on 51 different species found in the human gut and 61 different fatty acids produced by those species. The unique fatty acid signatures of the individual microorganisms were obtained by gas chromatography (provided by MIDI Inc). Several algorithms were developed in Matlab to differentiate individual species using the fatty acid composition data of the simulated mixtures. These algorithms utilized Hamming distance, least‐squares optimization, and combinatorics methods to identify the presence of each species. The algorithms were tested against myriad virtual samples to analyze their ability to detect the presence of selected species. While more complex mixtures of species decreased the probability of detection, we found that utilizing a constrained least‐squares method with Hamming‐based filters provided high probabilities of detection for all tested samples. This algorithm was capable of detecting the presence of a selected species over 90% of the time for instrument tolerances as high as 15%.
Chromosome missegregation causes colon cancer byAPCloss of heterozygosity (2010)

A longstanding hypothesis in the field of cancer biology is that aneuploidy causes cancer by promoting loss of chromosomes that contain tumor suppressor genes. By crossing aneuploidyprone Bub1 hypomorphic mice onto a heterozygous null background for p53, we provided conclusive evidence for this idea.(1) Surprisingly, the tumors that developed in this model had not just lost the chromosome 11 copy harboring wild-type p53, but had also gained an extra copy of chromosome 11 bearing the p53 null allele. Here we report that a similar chromosome-reshuffling blueprint drives colonic tumorigenesis in Bub1 hypomorphic mice that are heterozygous for Apc(Min), but now involving chromosome 18. These extended studies highlight that in order for whole chromosome instability to drive tumorigenesis, it needs to establish tumor suppressor gene loss of heterozygosity while retaining two copies of the other genes on the chromosome. Additional restrictions seem to apply to whole chromosome instability as a cancer causing mechanism, which will be discussed in this paper.
Simulation of bridge?heavy road vehicle interaction and assessment of structure durability (2003)

This paper describes a mathematical model for the prediction of the dynamic loads induced on a bridge structure by the passage of vehicles. The model is defined in the time domain and represents the bridge and the vehicles as dynamic systems interacting with each other via wheel–road contact forces. The numerical outcomes of the mathematical model are compared to measurements performed on an existing steel bridge, and show satisfactory agreement. The mathematical model was eventually applied to the estimation of load spectra corresponding to daily traffic. In particular, the load spectra corresponding to different vehicles and speeds were combined by using a statistical description of the traffic. It is shown that this procedure leads to results very close to the ones measured on the structure.