gebhart/patrepeval huggingface dataset:
Faculty Opinions recommendation of Clinical PARP inhibitors do not abrogate PARP1 exchange at DNA damage sites in vivo. (2020)

DNA breaks recruit and activate PARP1/2, which deposit poly-ADP-ribose (PAR) to recruit XRCC1-Ligase3 and other repair factors to promote DNA repair. Clinical PARP inhibitors (PARPi) extend the lifetime of damage-induced PARP1/2 foci, referred to as 'trapping'. To understand the molecular nature of 'trapping' in cells, we employed quantitative live-cell imaging and fluorescence recovery after photo-bleaching. Unexpectedly, we found that PARP1 exchanges rapidly at DNA damage sites even in the presence of clinical PARPi, suggesting the persistent foci are not caused by physical stalling. Loss of Xrcc1, a major downstream effector of PAR, also caused persistent PARP1 foci without affecting PARP1 exchange. Thus, we propose that the persistent PARP1 foci are formed by different PARP1 molecules that are continuously recruited to and exchanging at DNA lesions due to attenuated XRCC1-LIG3 recruitment and delayed DNA repair. Moreover, mutation analyses of the NAD + interacting residues of PARP1 showed that PARP1 can be physically trapped at DNA damage sites, and identified H862 as a potential regulator for PARP1 exchange. PARP1-H862D, but not PARylation-deficient PARP1-E988K, formed stable PARP1 foci upon activation. Together, these findings uncovered the nature of persistent PARP1 foci and identified NAD + interacting residues involved in the PARP1 exchange.
Pharmacokinetics, pharmacodynamics and efficacy on pediatric tumors of the glioma radiosensitizer KU 60019 (2014)

We have recently reported that glioblastoma (GB)-initiating cells (GIC) with low expression and/or mutation of TP53 and high expression of PI3K ("responder" genetic profile) can be effectively and safely radiosensitized by the ATM inhibitor KU60019. We report here on drug's diffusion and elimination from the animal body and brain, its effects on orthotopic GB and efficacy toward pediatric GIC. Healthy mice were infused by convection enhanced delivery (CED) with KU60019 and the drug kinetics followed by high performance liquid chromatography-mass spectrometry. Already at the end of CED, KU60019 had diffused from the injection site to the ipsilateral and, to a lower extent, controlateral hemisphere. After 24 hr, no drug could be detected all over the brain or in other organs, indicating rapid draining and excretion. After intraperitoneal injection, traces only of KU60019 could be detected in the brain, indicating inability to cross the brain-blood barrier. Consistent with the induction of cell cycle progression previously observed in vitro, KU60019 stimulated proliferation of orthotopic GB cells with the highest effect observed 96 hr after drug delivery. Adult GIC with high expression of TP53 and low expression of PI3K could be radiosensitized by KU60019, although less promptly than GIC bearing the "responder" profile. Consistent with the kinetics of proliferation induction, the highest radiosensitizing effect was observed 96 hr after delivery of KU60019 to GIC. Pediatric GIC could be similarly radiosensitized after exposure to KU60019. The results indicate that ATM inhibition may allow to radiosensitize a wide range of adult and pediatric high-grade gliomas.
Phase I-B development of kinematic Stirling/Rankine commercial gas-fired heat-pump system. Annual report, September 1983-December 1984 (1985)

The goal of this project is to develop a commercial-size Stirling engine-driven gas heat pump with a cooling capacity of 10 ton, and a COP (heating) of 1.8 and COP (cooling) of 1.1. The project is a multi-phase development with commercialization planned for 1989. A piston-type open-shaft refrigeration compressor was selected as the best match for the engine. Both the engine and compressor were tested and characterized by performance maps, and the experimental heat-pump systems designed. The manufacturer continued to focus on improving the Stirling-engine performance and reliability for the gas heat pump application.
Effects of proteasome inhibitors on rat renal fibrosis in vitro and in vivo (2010)

Proteasome inhibitors attenuate TGF-β signalling by blocking Smad signal transduction in vitro, but do not inhibit renal interstitial fibrosis in vivo.
Determination of Proximal Femoral Epiphyseal Depth for Repair of Physeal Fractures in Immature Dogs (1998)

Estimating the safe depth of implant placement into the PFE avoids penetration of the articular surface.
Toward ultra thin CIGS solar cells (2012)

In this paper, we present our results on the fabrication of solar cells down to thicknesses of 0.5 μm, and how real time and in situ analysis by spectroscopic ellipsometry (SE) can help in (i) understanding the results of the devices; and (ii) modeling the growth and properties of the CIGS solar cell. These in situ and real time measurements are correlated with ex situ structural measurements of the films such as XRD and AFM; broad spectral range optical measurements of the films and devices such as T&R, variable angle SE; and device specific measurements such as I-V and QE measurements.
Altered Allogeneic Response in Neonatally Anti‐MHC Class I‐Treated Mice (1996)

Neonatal treatment of C3H mice (H-2k) with anti-Kk monoclonal antibodies results in altered cytotoxic responses against allogeneic targets. After 2-3 weeks of antibody treatment, no difference in the number of CD4+8- or CD4-8+ T cells was observed between the antibody- and saline-treated mice. However, antibody-treated mice had a significantly reduced cytotoxic response against various allogeneic major histocompatibility complex (MHC) class I-expressing targets. The strongest reduction was observed in very young mice (up to 2 weeks of age). As the mice got older, the allo MHC-specific responses reached control levels. No significant changes in T-cell receptor (TCR)-V-region usage was observed even in young antibody-treated mice. The results suggest that the reduction in the number of positively selecting elements reduces alloreactivity and most likely also the diversity of TCR-repertoire. However, the reduced alloresponsiveness was not restricted to either allogeneic K- or D-encoded molecules, suggesting that self MHC-D-region encoded molecules can mediate positive selection of T cells able to react against both K and D region-encoded allogeneic MHC class I molecules.
Universal pressure and temperature SAW sensor for wireless applications (2002)

This work presents a universal SAW sensor device for measurement of either pressure or temperature or both simultaneously. An arrangement of three surface acoustic wave resonators (SAWRs) was used. The experimental sensor described in this paper employs a 35/spl deg/ Y cut quartz diaphragm and utilizes center frequencies ranging from 433 to 436 MHz. The sensor relies on differences in the dependence of each SAWR center frequency on pressure and temperature. A difference frequency measurement was used. The difference frequency outputs were used to determine pressure and temperature.
Formation of inclusion type silicon phases induced by inert gases (2018)

Abstract Silicon clathrate, an important allotrope of silicon, has attractive opto-electronic properties for energy applications. However, it remains an experimental challenge to synthesize electrically undoped, intrinsic clathrate. Here we show, through high-throughput computer modeling, that unconventional silicon phases spontaneously nucleate from liquid silicon in the presence of noble gases under high pressure and high temperature. In particular, our results show that a medium-sized noble gas, for example, argon, can trigger the nucleation and growth of inert-gas silicon clathrate, whereas a small noble gas such as helium is able to induce the formation of an unconventional, inclusion-type compound Si 2 He. The formation of both silicon phases can be attributed to the same thermodynamic and kinetic rationale that explains the crystallization of clathrate hydrate, an isostructural analog. Our findings, along with the gained molecular insights, thus strongly suggest a viable experimental synthesis route for these silicon phases using noble gases at high pressure.
Kondensierte Isochinoline, VIII. Isomerisierung und Ringöffnung bei substituierten s‐Triazolo[3.4‐a]isochinolinen (1971)

Abstract 6‐Cyan‐ s ‐triazolo[3.4‐ a ]isochinolin ( 3 ) wird in 10 proz. Natronlauge in 5‐Amino‐ s ‐triazolo[5.1‐ a ]isochinolin ( 6 ) und [2‐( s ‐Triazolyl‐(3))‐phenyl]‐essigsäure ( 8 ) übergeführt, wobei 8 zumindest teilweise aus 6 entsteht. 8 wird zum 5‐Hydroxy‐ s ‐triazolo[5.1‐ a ]isochinolin ( 9a ) cyclokondensiert, das auch aus 5‐Chlor‐ s ‐triazolo[3.4‐ a ]isochinolin ( 10 ) mit Kaliumhydroxid in DMSO entsteht. Sowohl aus 6‐Chlor‐ s ‐triazolo[3.4‐ a ]isochinolin ( 11 ) als auch aus dem 5‐Chlor‐Derivat 10 wird bei der Reaktion mit Natriummethylat in Methanol 5‐Methoxy‐ s ‐triazolo[3.4‐ a ]isochinolin ( 13 ) gebildet. Die Möglichkeit einer Eliminierungs‐Additions‐Sequenz wird diskutiert. Die Strukturen werden mit Hilfe der NMR‐Spektren gesichert.
Adverse reactions to indocyanine green: A case report and a review of the literature (1989)

Indocyanine green is a dye used primarily in cardiac output determinations, and in ophthalmic angiography. It has a low incidence of side effects; however, they occur and have included death. We report a case of anaphylactoid reaction to indocyanine green and review the literature on these reactions.
SIMD, SMP and MIMD-DM Parallel Approaches for Real-Time 2D Image Stabilization (2006)

We present a real-time image stabilization method, based on a 2D motion model and different levels of parallel implementation. This stabilization method is decomposed into three main parts. First, the image matching is determined by a feature-based technique, then the motion between consecutive frames is estimated and filtered to extract the unwanted motion component. This component is finally used to correct (warp) the images, resulting in a stable sequence. To validate our stabilization approach in a real-time on-board system context, the algorithm was implemented and tested over different hardware platforms, allowing a performance evaluation in function of the adopted architecture. In this paper, we present some of the results, concerning the parallel implementation of the algorithm, using the MW ALTIVEC/spl reg/ instructions set, a symmetric multi-processor (SMP) architecture and MIMD-DM architecture.
Variable-Bit-Rate Transmission Schedule Generation in Green Vehicular Roadside Units (2015)

Smart traffic scheduling can be used to reduce downlink roadside unit (RSU) energy use in green vehicular roadside infrastructure. In this paper, we consider the problem of downlink schedule generation when the RSU-to-vehicle radios use a variable bit rate (VBR) air interface. We first present offline scheduling formulations that provide lower bounds on the energy required to fulfill vehicle requests. An integer linear program is introduced that can be solved to find optimal offline VBR time slot schedules. We then prove that this problem is NP-complete by a reduction from the well-known Santa Claus problem. Two flow-graph-based models are then used to solve the minimum energy VBR scheduling problem. The first uses generalized flow (GF) graphs that represent time slots as individual graph nodes. The second uses time-expanded graphs (TEGs) that model the temporal evolution of the system. Both of these models can be used to compute lower bounds on energy performance and provide the basis for energy-efficient online schedulers. The first scheduler introduced, i.e., First-Come First-Serve (FCFS), is very simple and treats all vehicles equally and in the order of arrival. Since the time spent in energy-favorable locations decreases with higher vehicle speed, the second scheduler, i.e., Fastest First (FF), gives priority to faster moving vehicles. The greedy GF (G-GF) and greedy TEG (G-TEG) schedulers are then introduced, which are motivated by the two flow-graph-based models. The proposed algorithm performance is examined under different traffic scenarios, and they are found to perform well compared with the lower bound. Our results show that the less computationally intensive algorithms, i.e., FCFS and FF, can perform well under light load, but G-GF and G-TEG, while more complex, can provide near-optimal energy consumption and with reasonable demand dropping rates. The results also show that the G-GF and G-TEG algorithms are much more fair than the simpler algorithms in heavy-load situations.
An evaluation of molecular structure for various coals using the characterization chart. (1986)

SYNOPSIS: -The characterization chart proposed by authors illustrates relationship between aromaticity (fa) and atomic H/C ratio for polycyclic aromatic hydrocarbons, their hydrogenated and alkylated compounds.For an evaluation of average structure of coals using this chart, the effect of oxygen on atomic H/C ratio of coals should be taken into account. The oxygen-containing functional groups existing in a coal were classified into three types and correction factors of each type of oxygen for the atomic H/C ratio were shown. Using the experimental results of the type analysis of oxygen have been reported for various coals, an experimental equation for the correction of oxygen to the atomic H/C ratio was obtained as follow.(O/C) type1+2 (O/C) type2=0.73× (O/C) tota1where, H/C and (O/C) total are the atomic ratios obtained from element analysis. The value of (H/C) c is corrected atomic ratio, being meaningful in the characterization chart.The use of (H/C) c instead of (H/C), make it possible to evaluate more reliable molecular structure for various coals on the characterization chart. The relationship between fa and (H/C) c for various coals on the characterization chart also indicates the change of the average structure depending on coalification degree.
Fluorodeoxyglucose Positron Emission Tomography for the Diagnosis of Sarcoidosis in Patients with Unexplained Chronic Uveitis (2009)

(18)F-FDG PET may show focal uptake suggestive of sarcoidosis in patients with unexplained uveitis.
Novel Therapeutics for Aggressive Non-Hodgkin's Lymphoma (2011)

Application of advances in genomic and proteomic technologies has provided molecular insights into distinct types of aggressive B- and T-cell non-Hodgkin's lymphomas (NHLs). This has led to the validation of novel biomarkers of classification, risk-stratification, and druggable targets. The promise of novel treatments from genomic research has been slow to materialize because of the lack of a therapeutic signature for the distinct NHL subtypes. Patients with lymphoma with aggressive disease urgently require the development of novel therapies on the basis of investigation of dysregulated intracellular oncogenic processes that arise during lymphomagenesis. Although monoclonal antibodies have made significant contributions to the armamentarium of B-cell NHL therapy (eg, anti-CD20), parallel development of small-molecule inhibitors (SMIs) to intracellular targets has lagged behind. Despite these deficiencies, several promising anti-NHL therapies are in development that target immune kinases of the B-cell receptor signaling pathway, mammalian target of rapamycin complex, proteasome, DNA/histone epigenetic complex, antiapoptosis, neoangiogenesis, and immune modulation. This review focuses on novel SMI therapeutic strategies that target overlapping core oncogenic pathways in the context of the 10 hallmarks of cancer. Furthermore, we have developed the concept of a therapeutic signature using the 10 hallmarks of cancer, which may be incorporated into novel phase I/II drug development programs.
Cooperation between Viral and Bacterial Pathogens in Causing Human Respiratory Disease (2014)

Viruses that most commonly attack the human respiratory tract are influenza virus, parainfluenza viruses, respiratory syncytial virus (RSV), adenoviruses, measles virus, rhinoviruses, and coronaviruses. The main bacterial pathogens found in this tract are Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, Staphylococcus aureus, Neisseria meningitidis, Mycobacterium tuberculosis, Bordetella pertussis, and, in immunocompromised patients, Pseudomonas aeruginosa. This chapter describes how some of these viruses and bacteria can cooperate to cause respiratory diseases which are more severe than those caused by either pathogen alone. Clinical, pathological, and epidemiological observations on natural disease, which suggest that such cooperation occurs, are examined first. This is followed by experiments using either animal models or, occasionally, human infections which prove the case. Finally, the chapter talks about possible mechanisms to explain the increased severity of disease arising from dual infections.
Structural Effects and Reactivity in Guanylhydrazone Formation: Temperature Coefficients of Rate of Formation of Several Guanylhydrazones (1962)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructural Effects and Reactivity in Guanylhydrazone Formation: Temperature Coefficients of Rate of Formation of Several GuanylhydrazonesDavid W. Brooks and Joseph D. GettlerCite this: J. Org. Chem. 1962, 27, 12, 4469–4475Publication Date (Print):December 1, 1962Publication History Published online1 May 2002Published inissue 1 December 1962https://pubs.acs.org/doi/10.1021/jo01059a084https://doi.org/10.1021/jo01059a084research-articleACS PublicationsRequest reuse permissionsArticle Views86Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A storage-free data parasitizing scheme for wireless body area networks (2014)

With the increasing sophistication and maturity of biomedical sensors and the significant advances on low-power circuits and wireless communications technologies, wireless body area networks (WBANs) have emerged recently to provide pervasive health monitoring for humans. In WBANs, smart phones can serve as data sinks to forward the sensing data to back-end servers. Due to the battery concern of smart phones and the postural changes of humans, temporary disconnection between sensors and their associated smart phones may frequently happen in WBANs. In this case, the sensing data would be lost when the limited memory space of sensors overflows. To prevent excessive data loss, this paper proposes a scheme to parasitize the data on existing public Wi-Fi networks, once the links from sensors to the smart phones become unavailable. Specifically, an optimization problem to maximize the time during which data loss can be avoided by exploiting the data parasitizing scheme is formulated, where a decision set of the packets' size and sending timing to public Wi-Fi networks needs to be determined. We develop an offline algorithm to obtain an optimal decision set and present an efficient online algorithm for practical implementations. The feasibility of the proposed scheme and the efficacy of the algorithms are demonstrated through prototype implementations on a WBAN testbed with biomedical sensor devices for real-world experiments.
Development of a Low-Inductance Linear Alternator for Stirling Power Convertors (2017)

The free-piston Stirling power convertor is a promising technology for high efficiency heat-to-electricity power conversion in space. Stirling power convertors typically utilize linear alternators for converting mechanical motion into electricity. The linear alternator is one of the heaviest components of modern Stirling power convertors. In addition, state-of-art Stirling linear alternators usually require the use of tuning capacitors or active power factor correction controllers to maximize convertor output power. The linear alternator to be discussed in this paper, eliminates the need for tuning capacitors and delivers electrical power output in which current is inherently in phase with voltage. No power factor correction is needed. In addition, the linear alternator concept requires very little iron, so core loss has been virtually eliminated. This concept is a unique moving coil design where the magnetic flux path is defined by the magnets themselves. This paper presents computational predictions for two different low inductance alternator configurations, and compares the predictions with experimental data for one of the configurations that has been built and is currently being tested.
Simultaneous RF/EO Tracking and Characterization of Dismounts (2008)

Simultaneous RF
Two channel microfluidic CARS for quantifying pure vibrational contrast of model analytes (2010)

We discuss the combination of a CARS-imaging system with microfluidics. Such system is a versatile tool to quantify the relative contributions of resonant and non-resonant scattering at the CARS frequency. We will show that the twochannel microfluidic chip employed in combination with deuterated isotopomers as an internal standard allows for fast and quantitative detection of organic molecules by CARS microscopy. The experimental design enables the simultaneous measurement of both the chemically relevant Raman-resonant signal and the non-Raman-resonant background.
Morphology, Cocontinuity, and Conductive Properties of Anisotropic Polymer Blends (1999)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTMorphology, Cocontinuity, and Conductive Properties of Anisotropic Polymer BlendsChristoph H. Arns, Mark A. Knackstedt, Anthony P. Roberts, and Val W. PinczewskiView Author Information School of Petroleum Engineering, Australian Petroleum CRC, University of New South Wales, Sydney, NSW 2052, Australia; Department of Applied Mathematics, Research School of Physical Sciences and Engineering, Australian National University, Canberra ACT, 0200, Australia; and Department of Civil Engineering and Operations Research, Princeton University, Princeton, New Jersey 08544 Cite this: Macromolecules 1999, 32, 18, 5964–5966Publication Date (Web):August 13, 1999Publication History Published online13 August 1999Published inissue 1 September 1999https://pubs.acs.org/doi/10.1021/ma981476uhttps://doi.org/10.1021/ma981476ubrief-reportACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views269Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Electrical conductivity,Morphology,Polymer blends,Polymer morphology,Polymers Get e-Alerts