gebhart/patrepeval huggingface dataset:
Dipeptidyl peptidase IV and related enzymes in cell biology and liver disorders (2005)

DP (dipeptidyl peptidase) IV is the archetypal member of its six-member gene family. Four members of this family, DPIV, FAP (fibroblast activation protein), DP8 and DP9, have a rare substrate specificity, hydrolysis of a prolyl bond two residues from the N-terminus. The ubiquitous DPIV glycoprotein has proved interesting in the fields of immunology, endocrinology, haematology and endothelial cell and cancer biology and DPIV has become a novel target for Type II diabetes therapy. The crystal structure shows that the soluble form of DPIV comprises two domains, an alpha/beta-hydrolase domain and an eight-blade beta-propeller domain. The propeller domain contains the ADA (adenosine deaminase) binding site, a dimerization site, antibody epitopes and two openings for substrate access to the internal active site. FAP is structurally very similar to DPIV, but FAP protein expression is largely confined to diseased and damaged tissue, notably the tissue remodelling interface in chronically injured liver. DPIV has a variety of peptide substrates, the best studied being GLP-1 (glucagon-like peptide-1), NPY (neuropeptide Y) and CXCL12. The DPIV family has roles in bone marrow mobilization. The functional interactions of DPIV and FAP with extracellular matrix confer roles for these proteins in cancer biology. DP8 and DP9 are widely distributed and indirectly implicated in immune function. The DPL (DP-like) glycoproteins that lack peptidase activity, DPL1 and DPL2, are brain-expressed potassium channel modulators. Thus the six members of the DPIV gene family exhibit diverse biological roles.
Lymphocyte Chemotaxis Is Regulated by Histone Deacetylase 6, Independently of Its Deacetylase Activity (2006)

In this work, the role of HDAC6, a type II histone deacetylase with tubulin deacetylase activity, in lymphocyte polarity, motility, and transmigration was explored. HDAC6 was localized at dynamic subcellular structures as leading lamellipodia and the uropod in migrating T-cells. However, HDAC6 activity did not appear to be involved in the polarity of migrating lymphocytes. Overexpression of HDAC6 in freshly isolated lymphocytes and T-cell lines increased the lymphocyte migration mediated by chemokines and their transendothelial migration under shear flow. Accordingly, the knockdown of HDAC6 expression in T-cells diminished their chemotactic capability. Additional experiments with HDAC6 inhibitors (trichostatin, tubacin), other structural related molecules (niltubacin, MAZ-1391), and HDAC6 dead mutants showed that the deacetylase activity of HDAC6 was not involved in the modulatory effect of this molecule on cell migration. Our results indicate that HDAC6 has an important role in the chemotaxis of T-lymphocytes, which is independent of its tubulin deacetylase activity.
Supplementary Data from Functional Genomic Identification of Predictors of Sensitivity and Mechanisms of Resistance to Multivalent Second-Generation TRAIL-R2 Agonists (2023)

Supplementary Data from Functional Genomic Identification of Predictors of Sensitivity and Mechanisms of Resistance to Multivalent Second-Generation TRAIL-R2 Agonists
Universal device pairing using an auxiliary device (2008)

The operation of achieving authenticated key agreement between two human-operated devices over a short-range wireless communication channel (such as Bluetooth or WiFi) is referred to as "Pairing". The devices in such a scenario are ad hoc in nature, i.e., they can neither be assumed to have a prior context (such as pre-shared secrets) with each other nor do they share a common trusted on- or off-line authority. However, the devices can generally be connected using auxiliary physical channel(s) (such as audio, visual, etc.) that can be authenticated by the device user(s) and thus form a basis for pairing.
Organizing Supramolecular Functional Dye–Zeolite Crystals (2006)

Unidirektionale Antennen: Farbstoffe in den offenen Kanälen von robusten Monoschichten aus Zeolith-L-Kristallen auf einem Glassubstrat bewirken eine hierarchische Ordnung (siehe Bild). Werden die farbstoffbeladenen Monoschichten an einen externen Acceptor- oder Donor-Sperrfarbstoff an den Kanalenden gekuppelt, lässt sich elektronische Anregungsenergie von Donormolekülen im Kristall einfangen oder in einen Acceptor in den Kanälen injizieren.
Mechanical properties of electron beam treated carboxylated nitrile butadiene rubber (XNBR) composites reinforced by organic/inorganic hybrid filler (2011)

Two types of carboxylated nitrile butadiene rubber (XNBR) composites were prepared; one of which was XNBR reinforced with organic filler-based olive solid by-product (OSB) and the other was XNBR reinforced with a combination of OSB and organo-layered nanoclay. To enhance the interaction between both the fillers and the matrix, the samples were exposed to electron beam (EB) treatment under ambient conditions. The samples were inspected with reference to their mechanical and dynamic mechanical (DMA) properties. It has been found that the tensile strength at break was enhanced after EB treatment for both composites. Such scenario was attributed to the irradiation-induced vulcanization. To support the observed trend, the pulse nuclear magnetic resonance technique was implemented. It has been found that the relaxation time ( T 2 ) was shortened after EB treatment. As further evidence on the fact that EB treatment was effective, the attenuated total reflectance infrared spectra were utilized as well. The IR results showed an increment in the spectra intensities after EB treatments. Scanning electron microscope revealed that EB treatment has turned their surface rough with an improved interaction between the matrix and the filler. DMA results were in harmony with the tensile properties in the sense that increased elastic modulus ( E′) with filler incorporation. The intensity of the mechanical loss factor (tan δ) was a sign on the reinforcing capability of the fillers as well as improved interaction between the composite components.
Advanced Pattern Recognition Approach for Fault Diagnosis of Wind Turbines (2013)

The production of maximum amount of electrical power from wind requires the improvement of wind turbine reliability. The life duration and the good functioning of the wind turbine depend heavily on the reliability of its blades. Thus, a critical task is to detect and isolate faults, as fast as possible, and regain optimal functioning in the shortest time. In this paper, a pattern recognition approach is proposed for fault diagnosis of a wind turbine, in particular the pitch system composed of actuators and sensors. To achieve this task, feature and decision spaces have been defined. The aim of the pitch system is to adjust the pitch angle of a blade in order to optimize the generated electrical power according to the wind speed. Thus, a fault in the pitch system can reduce the wind turbine performance. Pitch system fault diagnosis is a challenging task because the pitch system feedback compensates the effect of the fault in the pitch actuator. In addition, the observation of the pitch actuator performance is very hard due to the strong variability of the wind speed. A wind turbine simulator is used to validate the performance of the proposed approach.
A Small‐Molecule Probe for Selective Profiling and Imaging of Monoamine Oxidase B Activities in Models of Parkinson’s Disease (2015)

Abstract The design of the first dual‐purpose activity‐based probe of monoamine oxidase B (MAO‐B) is reported. This probe is highly selective towards MAO‐B, even at high MAO‐A expression levels, and could sensitively report endogenous MAO‐B activities by both in situ proteome profiling and live‐cell bioimaging. With a built‐in imaging module as part of the probe design, the probe was able to accomplish what all previously reported MAO‐B imaging probes failed to do thus far: the live‐cell imaging of MAO‐B activities without encountering diffusion problems.
The Hemolymph of the Ascidian Styela plicata (Chordata-Tunicata) Contains Heparin inside Basophil-like Cells and a Unique Sulfated Galactoglucan in the Plasma (2006)

The hemolymph of ascidians (Chordata-Tunicata) contains different types of hemocytes embedded in a liquid plasma. In the present study, heparin and a sulfated heteropolysaccharide were purified from the hemolymph of the ascidian Styela plicata. The heteropolysaccharide occurs free in the plasma, is composed of glucose ( approximately 60%) and galactose ( approximately 40%), and is highly sulfated. Heparin, on the other hand, occurs in the hemocytes, and high performance liquid chromatography of the products formed by degradation with specific lyases revealed that it is composed mainly by the disaccharides DeltaUA(2SO(4))-1-->4-beta-d-GlcN(SO(4)) (39.7%) and DeltaUA(2SO(4))-1-->4-beta-d-GlcN(SO(4))(6SO(4)) (38.2%). Small amounts of the 3-O-sulfated disaccharides DeltaUA(2SO(4))-1-->4-beta-d-GlcN(SO(4))(3SO(4)) (9.8%) and DeltaUA(2SO(4))-1-->4-beta-d-GlcN(SO(4))(3SO(4))(6SO(4)) (3.8%) were also detected. These 3-O-sulfated disaccharides were demonstrated to be essential for the binding of the hemocyte heparin to antithrombin III. Electron microscopy techniques were used to characterize the ultrastructure of the hemocytes and to localize heparin and histamine in these cells. At least five cell types were recognized and classified as univacuolated and multivacuolated cells, amebocytes, hemoblasts, and granulocytes. Immunocytochemistry showed that heparin and histamine co-localize in intracellular granules of only one type of hemocyte, the granulocyte. These results show for the first time that in ascidians, a sulfated galactoglucan circulates free in the plasma, and heparin occurs as an intracellular product of a circulating basophil-like cell.
[Effect of Health Poverty Alleviation Project on the Economic Burden of Disease Among Poor Households: Empirical Evidence from Sichuan Province]. (2023)

Health Poverty Alleviation Project reduces the economic burden of disease for poor households, and it has a better effect on reducing the economic burden of poor households in poverty-stricken counties. However, a certain number of households still incurred catastrophic health expenditures. When consolidating and expanding the effects of Health Poverty Alleviation Project and monitoring medical expenses for poverty prevention, policymakers should focus on the households with catastrophic medical expenditures to prevent them from sinking back into poverty.
Production of Recombinant Proteins in Tobacco Guttation Fluid (2000)

Guttation, the loss of water and dissolved materials from uninjured plant organs, is a common phenomenon in higher plants. By using endoplasmic reticulum signal peptides fused to the recombinant protein sequences, we have generated transgenic tobacco (Nicotiana tabacum L. cv Wisconsin) plants that secrete three heterologous proteins of different genetic backgrounds (bacterial xylanase, green fluorescent protein of jellyfish [Aequorea victoria], and human placental alkaline phosphatase) through the leaf intercellular space into tobacco guttation fluid. Production rates of 1.1 microg/g of leaf dry weight per day were achieved for alkaline phosphatase with this protein comprising almost 3% of total soluble protein in the guttation fluid. Guttation fluid can be collected throughout a plant's life, thus providing a continuous and nondestructive system for recombinant protein production. Guttation fluid has the potential of increasing the efficiency of recombinant protein production technology by increasing yield, abolishing extraction, and simplifying its downstream processing.
Cold Atmospheric Plasma (2008)

In this decade we are witnessing a dynamic development of cold atmospheric plasma technologies. While the thermal atmospheric plasma found their applications in a broader scale already in the middle of the last century, the non-equilibrium, non-thermal or “cold” plasma systems have attracted a considerable technological interest much later. It is despite the fact that cold atmospheric plasma systems based on corona discharges were tested for production of ozone in the middle of 19th century by W. von Siemens. One of the greatest engineering science contributions enabling development of cold atmospheric plasma systems has been the invention of alternating current (ac) electric power systems by N. Tesla. Above a certain frequency of the ac power the motion of electrons and ions start to decouple. Therefore at high frequencies, like for example at microwave generation, the power is preferentially absorbed by the electrons while ions as well as the rest of neutral gas remain cold. Moreover, alternating fields represent an important stabilization factor for discharges. The cold atmospheric plasma is being employed mainly in surface treatment, in cleaning, disinfection and decontamination and in coating technologies. It also has a high potential in environmental technologies, in decomposing hazardous gases from exhausts, flue gas, from energy production and in transforming byproducts and chemical compounds from different industries. Cold atmospheric plasma systems and applications are closely related to specific properties of the gas at the atmospheric pressure, particularly to high collision frequency of particles, limiting both the mean free path and transport of particles as well as their maximum energies. Cold atmospheric plasma has been over the years anchored e.g. at the International Symposium on Plasma Chemistry but with development of plasma sources and plasma processing at atmospheric pressure, non-equilibrium plasma has entered also technological conferences. Thus, the first Cold Atmospheric Plasma Technologies symposium at the Electrochemical Society Meeting was held in 2001 in Washington, DC, regular sessions on cold atmospheric plasma were opened e.g. at the International Conference on Metallurgical Coatings and Thin Films (ICMCTF) and AVS Meetings. In 2008, a new session “Deposition and plasma surface treatment at atmospheric pressure” will be organized at the AVS Meeting. A new series of invited articles on Cold Atmospheric Plasma will be published through 2008 and possibly also in 2009 in Plasma Processes & Polymers. The papers will be Feature Articles or Review Articles from the field, devoted to and covering different aspects from this R&D area, mechanisms and diagnostics of the discharges, various concepts of plasma sources, different applications and scale up issues. We believe that important results and interesting overviews will bring about also interesting parallels through different technologies. We are convinced that the series will bring stimulating ideas and inspiration to the readers.
Stixel based scene understanding for autonomous vehicles (2017)

We propose a stereo vision based obstacle detection and scene segmentation algorithm appropriate for autonomous vehicles. Our algorithm is based on an innovative extension of the Stixel world, which neglects computing a disparity map. Ground plane and stixel distance estimation is improved by exploiting an online learned color model. Furthermore, the stixel height estimation is leveraged by an innovative joined membership scheme based on color and disparity information. Stixels are then used as an input for the semantic scene segmentation providing scene understanding, which can be further used as a comprehensive middle level representation for high-level object detectors.
Petroleum Processing Handbook (1992)

A reference that details the pertinent chemical reactions and emphasizes the plant design and operations of petroleum processing procedures. The handbook is divided into four sections: products, refining, manufacturing processes, and treating processes. Wherever possible, shortcut methods of calcula
Arthroscopic studies of variants of the anterior horn of the medial meniscus (1997)

The objective of this study was to arthroscopically analyse the morphology and dynamics of variants of the anterior horn of the medial meniscus of the knee (VAMM) and to then consider the pathological significance of these variants. VAMM was defined as knees in which the anterior horn of the medial meniscus is not attached to the tibia. Between April 1992 and March 1995, arthroscopy was performed on 953 knees of 903 patients. At the time of this examination, observation and probing were performed to determine the condition of the synovium, the synovial plica, the cartilage in all compartments, the meniscus, the cruciate ligaments, and the popliteal tendon. In particular, detailed examination was made of the anterior horn of the medial meniscus with regard to the point of insertion to the tibia and the degree of movement in knee flexion/ extension. Cases of VAMM diagnosed on the basis of the arthroscopic findings were classified into the following four categories: the ACL (anterior cruciate ligament) type, where the anterior horn of the medial meniscus was attached to the ACL; the transverse ligament type, where the anterior horn of the medial meniscus was attached to the transverse ligament; the coronary ligament type, where the anterior horn of the medial meniscus was attached to the coronary ligament; and the infrapatellar fold type, where the anterior horn of the medial meniscus was attached to the infrapatellar synovial fold. These patients were then analyzed with regard to the arthroscopic findings and the intra-articular lesions other than VAMM. In 98 (10.9%) of the total patients, 103 knees were classified as VAMM. Classification of those 103 knees using the above criteria showed 39 ACL type knees, 51 transverse ligament type knees, 11 coronary ligament type knees, and 2 infrapatellar fold type knees. The arthroscopic findings indicated that the anterior horn of the medial meniscus was not attached directly to the tibia in any of these knees. Probing and flexion/extension of the knee revealed hypermobility at the anterior horn of the medial meniscus. In this study, anterior knee pain syndrome was diagnosed in 12 (11.7%) of the 103 VAMM knees. In addition, there was no clear history of trauma in 20 of 23 knees found to have an isolated medial meniscus tear. In these cases, even detailed arthroscopic observation proved the causes of the symptoms or injury. On the basis of these findings, we surmised that the anterior portion shows hypermobility at the time of flexion/extension of the knee, regardless of the type of VAMM. In this study, we discussed the possibility that the existence of VAMM may become the cause of pain or injury to the meniscus.
Power generation technology and potential analysis of coal bed methane in coal mine area in China (2004)

China is endowed with abundant coal bed methane, the extraction-evacuation quantity of coal hed methane in coal mine area is
going rapidly up year by year. To make full use of this coal bed methane resource has the multiple benefits of raising sare production level
of coal mine, increasing clean energy and protecting environment etc., and thus meets China's energy policy. This paper briefs the coal bed
methane resources situation in China, and analyzes the coal bed methane-fired power generation technology and market etc.
6.7 A 1.2e− temporal noise 3D-stacked CMOS image sensor with comparator-based multiple-sampling PGA (2016)

This paper presents a 1.2e-, 3D-stacked CMOS image sensor (CIS) for mobile applications. A key motivation for using a stacked configuration is to minimize the chip area. Also, since numerous components must be integrated into the bottom chip, a scaled 65nm CMOS process is adopted for the bottom chip. The developed CIS features 1.2e- temporal noise with extremely high power efficiency by employing a multiple-sampling (MS) technique. A 2nd-order incremental ΔΣ ADC with inverter-based switched-capacitor integrator realizes the MS technique with low power [1]. However, an exponential number of samples are required to reduce the quantization noise, and conversion speed worsens with higher bit resolution. An extended counting ADC, which is a blend of folding integration and cyclic ADC, attains high resolution with reduced conversion time [2-3]. However, an op-amp with high open-loop gain is required for good linearity and column-to-column matching characteristics, which increases power consumption. Also it is not suitable for scaled CMOS technology. An alternative approach is a single-slope (SS) based MS technique [4], in which two SS-ADCs convert the same pixel signal, and the readout signal is averaged in the digital domain, but the noise improvement is limited to -3dB and the power consumption and area occupation are roughly doubled.
Limited angle tomography using regularized extrapolation technique (2002)

Considers the well-known limited angle or missing cone problem. The authors present an alternative method to extrapolate the missing set of projection data from limited angle of views without prior information of the scanning object, using two-dimensional sampling theory and the result by Rattey and Lindgren which shows that the spectral support of computerised tomography (CT) projection data is bowtie-shaped. A general matrix formulation is developed and the problem is posed as a least square optimization problem. This problem is then implemented by a nonstandard neural network. A novel training algorithm is proposed minimizing a modified error criterion. A computer simulation result is presented to demonstrate the validity of the algorithm.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Radiosensitization with combined use of olaparib and PI-103 in triple-negative breast cancer (2015)

Combined use of olaparib and PI-103 enhanced radiation-induced cell death in BRCA-proficient MDA-MB-435S and MDA-MB-231-BR cells and xenografts. TNBC patients have high incidences of locoregional relapse and distant metastasis, and radiation therapy targets both locoregional control and treatment of distant recurrences such as brain metastasis or other oligometastasis. Targeting of the PI3K signaling pathway combined with PARP inhibition maybe a feasible approach to enhance effects of radiation in BRCA-proficient TNBC.
A Nanoporous Reactor for Efficient Proteolysis (2007)

Abstract A nanoreactor based on mesoporous silicates is described for efficient tryptic digestion of proteins within the mesochannels. Cyano‐functionalized mesoporous silicate (CNS), with an average pore diameter of 18 nm, is a good support for trypsin, with rapid in situ digestion of the model proteins, cytochrome c and myoglobin. The generated peptides were analyzed by matrix‐assisted laser desorption ionization time‐of‐flight mass spectrometry (MALDI‐TOF MS). Proteolysis by trypsin‐CNS is much more efficient than in‐solution digestion, which can be attributed to nanoscopic confinement and concentration enrichment of the substrate within the mesopores. Proteins at concentrations of 2 ng μL −1 were successfully identified after digestion for 20 min. A biological complex sample extracted from the cytoplasm of human liver tissue was digested by using the CNS‐based reactor. Coupled with reverse‐phase HPLC and MALDI‐TOF MS/MS, 165 proteins were identified after standard protein data searching. This nanoreactor combines the advantages of short digestion time with retention of enzymatic activity, providing a promising way to advance the development of proteomics.