gebhart/patrepeval huggingface dataset:
A Traffic Equilibrium Model with Area-Based Non Additive Road Pricing Schemes (2008)

In the definition of non additive path, the sum of travel costs of links making up the path is not equal to the path cost. There are a variety of cases that non-additivity assumption does not hold in transportation fields. Nonetheless, traffic equilibrium models are generally built up on the fundamental hypothesis of additivity assumption. In this case traffic equilibrium models are only applicable within restrictive conditions of the path cost being linear functions of link cost. Area-wide road pricing is known as an example of realistic transportation situations, which violates such additivity assumption. Because travel fare is charged at the moment of driver's passing by exit gate while identified at entry gate, it may not be added linearly proportional to link costs. This research proposes a novel Wordrop type of traffic equilibrium model in terms of area-wide road pricing schemes. It introduces binary indicator variable for the sake of transforming non-additive path cost to additive. Since conventional shortest path and Frank-Wolfe algorithm can be applied without route enumeration and network representation is not required, it can be recognized more generalized model compared to the pre-proposed approaches. Theoretical proofs and case studies are demonstrated.
Effect of the nucleation processon freestanding ALN/diamond SAW filter characteristics (2004)

In this work, the effect of diamond nucleation process on freestanding AlN/diamond SAW device performances was studied. Before diamond deposition, silicon substrate were mechanically nucleated, using an ultrasonic vibration table with sub-micron diamond slurry, and bias enhanced nucleated (BEN). Freestanding diamond layers obtained on mechanically scratched Si substrates exhibit a surface roughness of R/sub MS/=13nm whereas very low surface roughness (as low as R/sub MS//spl les/1 nm) can be achieved on BEN diamond layer. Propagation losses (/spl alpha/) and electromechanical coupling coefficient (K/sup 2/) have been measured as a function of the operating frequency and the normalized AlN film thickness (kh/sub AlN/=2/spl pi/h/sub AlN///spl lambda/). Experimental results show that the propagation losses strongly depend on nucleation technique while the electromechanical coupling coefficient slightly depends on nucleation technique.
HSP27 PROMOTES IGF-1 SURVIVAL SIGNALING IN PROSTATE CANCER VIA P90RSK-DEPENDENT PHOSPHORYLATION AND INACTIVATION OF BAD (2009)

You have accessJournal of Urology1 Apr 2009HSP27 PROMOTES IGF-1 SURVIVAL SIGNALING IN PROSTATE CANCER VIA P90RSK-DEPENDENT PHOSPHORYLATION AND INACTIVATION OF BAD Amina Zoubeidi, Anousheh Zardan, Jennifer Lock, Eliana Beraldi, Ladan Fazli, and Martin E Gleave Amina ZoubeidiAmina Zoubeidi More articles by this author , Anousheh ZardanAnousheh Zardan More articles by this author , Jennifer LockJennifer Lock More articles by this author , Eliana BeraldiEliana Beraldi More articles by this author , Ladan FazliLadan Fazli More articles by this author , and Martin E GleaveMartin E Gleave More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(09)61449-XAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "HSP27 PROMOTES IGF-1 SURVIVAL SIGNALING IN PROSTATE CANCER VIA P90RSK-DEPENDENT PHOSPHORYLATION AND INACTIVATION OF BAD." The Journal of Urology, 181(4S), p. 513 © 2009 by American Urological AssociationFiguresReferencesRelatedDetails Volume 181Issue 4SApril 2009Page: 513 Advertisement Copyright & Permissions© 2009 by American Urological AssociationMetricsAuthor Information Amina Zoubeidi More articles by this author Anousheh Zardan More articles by this author Jennifer Lock More articles by this author Eliana Beraldi More articles by this author Ladan Fazli More articles by this author Martin E Gleave More articles by this author Expand All Advertisement PDF downloadLoading ...
Visual Experience Facilitates BDNF-Dependent Adaptive Recruitment of New Neurons in the Postembryonic Optic Tectum (2018)

Postembryonic brain development is sensitive to environmental input and sensory experience, but the mechanisms underlying healthy adaptive brain growth are poorly understood. Here, we tested the importance of visual experience on larval zebrafish (<i>Danio rerio</i>) postembryonic development of the optic tectum (OT), a midbrain structure involved in visually guided behavior. We first characterized postembryonic neurogenic growth in OT, in which new neurons are generated along the caudal tectal surface and contribute appositionally to anatomical growth. Restricting visual experience during development by rearing larvae in dim light impaired OT anatomical and neurogenic growth, specifically by reducing the survival of new neurons in the medial periventricular gray zone. Neuronal survival in the OT was reduced only when visual experience was restricted for the first 5 d following new neuron generation, suggesting that tectal neurons exhibit an early sensitive period in which visual experience protects these cells from subsequent neuronal loss. The effect of dim rearing on neuronal survival was mimicked by treatment with an NMDA receptor antagonist early, but not later, in a new neuron's life. Both dim rearing and antagonist treatment reduced BDNF production in the OT, and supplementing larvae with exogenous BDNF during dim rearing prevented neuronal loss, suggesting that visual experience protects new tectal neurons through neural activity-dependent BDNF expression. Collectively, we present evidence for a sensitive period of neurogenic adaptive growth in the larval zebrafish OT that relies on visual experience-dependent mechanisms.<b>SIGNIFICANCE STATEMENT</b> Early brain development is shaped by environmental factors via sensory input; however, this form of experience-dependent neuroplasticity is traditionally studied as structural and functional changes within preexisting neurons. Here, we found that restricting visual experience affects development of the larval zebrafish optic tectum, a midbrain structure involved in visually guided behavior, by limiting the survival of newly generated neurons. We found that new tectal neurons exhibit a sensitive period soon after cell birth in which adequate visual experience, likely mediated by neuronal activity driving BDNF production within the tectum, would protect them from subsequent neuronal loss over the following week. Collectively, we present evidence for neurogenic adaptive tectal growth under different environmental lighting conditions.
A general reductive denitration method for regiospecific deuteriation of the porphyrin nucleus: synthesis of [20-2H1]mesoporphyrin IX dimethyl ester (1985)

Treatment of meso- or β-nitroporphyrins with deuteriated lithium hydroxide and [N,N,S-2H3]2-aminobenzenethiol in dry N,N-dimethylformamide results in replacement of the nitro group with deuterium; the regiospecificity of the process is demonstrated by synthesis of [20-2H1]mesoporphyrin IX dimethyl ester.
[The cellular composition of the iliac lymph nodes and thymus in mice under local x-ray irradiation of the gonads at high and low doses]. (1992)

The cellular composition of iliac lymph nodes and thymus of 150 male white mice was studied 4 weeks after local irradiation of the gonads by doses 7.34 and 360 cGr by histological and electron microscopic methods. Intact animals and corresponding groups of false irradiation were used as control. Changes of the cellular composition of B-dependent zones of the lymph nodes were shown both after irradiation by high (360 cGr) and low (7 cGr) doses. The effect of irradiation by the dose 34 cGr on the content of certain cell forms was less while the ultrastructural transformations were more pronounced than those caused by weak X-ray irradiation. Certain similarity was established in the dynamics of cell reactions in false irradiation of the animals (imitation control) and irradiation by low doses. A supposition is put forward concerning the influence of non-irradiation factors accompanying the irradiation on the value and character of the response to radiation loads of low intensity.
Joint Proportional Fair Scheduling for Uplink and Downlink in Wireless Networks (2011)

Since many users share limited wireless resources in wireless networks, it is important for resources to be allocated among users in a fair and efficient manner. The scheduler at the base station is responsible for allocating resources to users. Many researchers have developed efficient scheduling algorithms but most these algorithms were designed separately and independently for the uplink or downlink. Because a user generally has two communication links, an uplink and a downlink, the overall satisfaction with a communication service can be formulated as the sum of the quality of the uplink and downlink services. Hence, the poor quality of either link can degrade the overall quality of service. This paper proposes a joint proportional fair (PF) scheduling algorithm for wireless networks, where the scheduling of the uplink and downlink is done jointly so that the bandwidth can be shared efficiently and fairly between the uplink and the downlink. The paper introduces three joint scheduling algorithms: joint delay-based scheduling, joint maximum rate scheduling, and joint PF scheduling. The simulation results show that in comparison with conventional scheduling algorithms the proposed joint PF scheduling algorithm achieves a better compromise between the throughput and user fairness by adjusting the weighting factor between the uplink and downlink.
Quick and accurate Q parameterization in viscoelastic wave modeling (2006)

Abstract We introduce a procedure for including the attenuation factor Q in a consistent manner in seismic modeling and show 3D examples. The Q fitting over a chosen frequency band involves two algorithms: The first creates starting values of relaxation times, and the second does nonlinear inversion using the results of the first as initial values. The resulting Q function gives a good approximation to a constant Q over the chosen frequency band. The algorithm is combined with a finite-difference (F-D) code that includes topographies in 3D seismic media. The velocity-stress formulation for viscoelastic wave modeling is used with an arbitrary number of relaxation mechanisms to model a desired Q behavior. These equations are discretized by high-order F-Ds in the interior of the medium, and we gradually reduce the F-D order to two at the stress-free surface, where we implement our free-surface boundary conditions. The seismic F-D algorithm is applied to a marine seismic experiment, with and without viscoelasticity, to emphasize the importance of including physical attenuation and dispersion in seismic modeling. Their inclusion, even for marine surveys, is clearly important for lossy ocean bottoms. Our procedure for more accurate modeling of physical dispersion and attenuation may increase future motivation to include viscoelasticity in seismic inversion.
Dual high-frequency chopper-based single stage PFC converter with output DC high quality (2009)

This paper presents a one stage circuit topology for a double buck chopper type single phase PFC converter with active power filtering function in a utility AC grid side and DC output power quality, which can realize much smaller in reactor size and lighter in its weight, along with two unique channel control schemes. The main advantageous point of the newly-proposed PFC converter includes that the output DC output voltage ripple factor can be minimized by using two channel pluse modulation control loops. In addition, the active PFC converter treated here can also effectively suppress the line current harmonics in utility AC grid without any specific feedback control scheme employing a current sensor interface circuit. In this paper, the operating principle of new PFC AC-DC converter circuit using power MOSFETs and its related PWM control implementation are described, including its simulation and experimental results. The effective modified PFC converter topologies such as high-frequency link, double boost and double buck-boost topologies, which can operate under the same plinciple as the proposed two channel control scheme, are discussed notion.
Pitting Resistance of Nitinol Stents before and after Implantation (2009)

Abstract This study explores the pitting susceptibility of Nitinol wires with blue oxide surfaces before processing into a vascular graft device, after processing, and explanted after in vivo exposure during a clinical trial. Only two explanted devices were made available for testing. The blue oxide surfaces of the control specimens tended to perform poorly in a commonly performed cyclic polarization test intended to screen implantable devices for pitting susceptibility, however the explanted devices performed far better under the same test conditions. Electrochemical polarization, x-ray photoelectron spectroscopy, optical and scanning electron microscopies were performed on adjacent wire samples cut from selected specimens. It must be noted that some of the details of handling and storage for the explants from the time of removal to the time that they were provided for analysis are unknown. Many screening tests are intentionally aggressive, the goal being to provide an adequate safety margin for acceptability. Nonetheless, these results raise potential questions regarding the environmental parameters of the in vitro screening test and whether it is always a reliable indicator of in vivo performance.
Identity of Lupin Inhibitor with Abscisin II and its Biological Activity on Growth of Rice Seedlings (1966)

Journal Article Identity of Lupin Inhibitor with Abscisin II and its Biological Activity on Growth of Rice Seedlings Get access Koichi Koshimizu, Koichi Koshimizu Department of Agricultural Chemistry, Kyoto University Search for other works by this author on: Oxford Academic Google Scholar Hiroshi Fukui, Hiroshi Fukui Department of Agricultural Chemistry, Kyoto University Search for other works by this author on: Oxford Academic Google Scholar Tetsuo Mitsui, Tetsuo Mitsui Department of Agricultural Chemistry, Kyoto University Search for other works by this author on: Oxford Academic Google Scholar Yukiyoshi Ogawa Yukiyoshi Ogawa Laboratory of Applied Botany, Faculty of Agriculture, Kyoto University Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 30, Issue 9, 1 September 1966, Pages 941–943, https://doi.org/10.1080/00021369.1966.10858708 Published: 01 September 1966 Article history Received: 14 July 1966 Published: 01 September 1966
NON-INVASIVE POLARIMETRIC GLUCOSE MEASUREMENT SYSTEM FOR EYE PHANTOMS AND IN-VIVO MEASUREMENT REQUIREMENTS (2003)

Non-invasive monitoring of the glucose level is a key technology for improved diagnosis and therapy for Diabetes patients. Optical measurement techniques like polarimetry measuring at the human eye offer promising properties for non-invasive and painless application. This article presents a polarimetric measurement system utilizing the polarizing properties of the Aqueous Humour (AH) for quantative glucose measurements, in particular the special requirements of in-vivo measurements for such a system are discussed
Cooperative Co-Evolution-Based Design Optimization: A Concurrent Engineering Perspective (2017)

As a well-known engineering practice, concurrent engineering (CE) considers all elements involved in a product's life cycle from the early stages of product development, and emphasizes executing all design tasks simultaneously. As a result, there exist various complex design problems in CE, which usually have many design parameters or require different disciplinary knowledge to solve them. To address these problems and enable concurrent design, different methods have been developed. The original problem is usually divided into small subproblems so that each subproblem can be solved individually and simultaneously. However, good decomposition, optimization, and communication strategies among subproblems are still needed in the field of CE. This paper attempts to study and analyze cooperative co-evolution (CC) based design optimization in CE by employing a parallel CC framework. Furthermore, it aims to develop new concurrent design methods based on parallel CC to solve different kinds of CE problems. To achieve this goal, a new novelty-driven CC is developed for design problems with complex structures and a novel concurrent design method is presented for quasi-separable multidisciplinary design optimization (MDO) problems. The efficacy of the new methods is studied on universal electric motor design problems and a general MDO problem, and compared to that of some existing methods. Additionally, this paper studies how the communication frequency among subpopulations affects the performance of the proposed methods. The optimal communication frequencies under different communication costs are reported as experimental results for both proposed methods on the test problems. Based on this paper, an effective self-adaptive method is proposed to be used in both optimization schemes, which is able to adapt the communication frequency during the optimization process.
PSVII-9 Effects of a multi-species direct-fed microbial on growth performance and carcass characteristics of grow-finish pigs (2019)

Abstract This study was conducted to determine the effects of a multi-species direct-fed microbial (DFM) product based on lactic acid bacteria and Bacillus subtilis on growth performance and carcass characteristics of grow-finish pigs. A total of 1,188 pigs (PIC 359 × 1050; initially 25.8 kg BW) were used in a 121-d growth trial with 27 pigs/pen and 22 pens/treatment. Pigs were allotted to treatments based on initial BW in a randomized complete block design. Treatments included a control diet and the control diet with added DFM (BiOWiSH Technologies Inc., Cincinnati, OH) included at 0.055% of the diet at the expense of corn. Diets were based on corn, distillers dried grains with solubles, and soybean meal and fed in four dietary phases. Data were analyzed using a linear mixed model (PROC GLIMMIX, SAS®) with treatment as fixed effect, block as random effect, and pen as experimental unit. Overall (d 0 to 121), pigs fed the control diet had greater ADG (P &lt; 0.05) and final BW (P &lt; 0.001) compared to pigs fed the DFM diet (Table 1). There was no evidence for differences (P &gt; 0.05) in ADFI or G:F between treatments. The difference in final BW resulted in heavier (P &lt; 0.05) HCW in control pigs compared to DFM pigs, but no evidence for differences (P &gt; 0.05) was observed in carcass yield, backfat, loin depth, and percentage lean between treatments. In conclusion, the inclusion of this multi-species DFM in growing-finishing diets reduced ADG in this commercial study. This response could be related to inclusion rate, feeding duration, or other factors not identified in this study, warranting further research to characterize the effects on pig performance.
Vers une approche à champs moyens à longueurs internes validée par \n dynamique des champs de dislocations : application aux effets de taille de particules \n dures dans un matériau de type ferrite / carbures (2011)

Une approche à champs moyens à longueurs&#13;\n internes rend compte des effets de taille d’inclusions dures noyées dans une matrice&#13;\n ferritique. Une couche intermédiaire entre l’inclusion et la matrice reflète la présence&#13;\n de GND dues aux gradients de distorsion plastique. L’épaisseur de cette couche et ses&#13;\n effets sur l’écrouissage sont obtenus à l’aide d’une théorie mécanique des champs de&#13;\n dislocations basée sur l’incompatibilité de réseau et l’équation de transport des&#13;\n dislocations de Mura.
Traffic-based quantitative risk analysis of structural fire damage to roadway tunnel linings (2021)

This paper demonstrates a quantitative risk analysis (QRA) approach of fire-induced damage to the reinforced concrete linings in roadway tunnels. Large fire events associated with buses and heavy goods vehicles are the focus of this study because their impact on the tunnel linings is structurally significant versus fires from smaller vehicles. The proposed approach accounts for stochastic variations of fire severity and frequency (based on traffic volume and the percentage breakdown by vehicle type) as well as the consequences (structural and economic) of thermal exposure to tunnel linings. The probabilistic distribution of fire size is developed using available weight-in-motion data, and combustible vehicle mass is correlated with the peak heat release rate using published test data and forensic reports. The heat transfer from the vehicle fire to the tunnel linings was modelled by a fast-running computational tool that was previously developed by the authors. Fire-induced damage to the tunnel linings is categorized into three levels of progressive strength reduction and cracking potential. Economic impacts are calculated in terms of estimated repair costs. The proposed approach enables informed decision making for the design or renovation of tunnel fire protection by quantifying the loss potential for severe fire hazards in a given tunnel.
Structure and Function of C-terminal Catalytic Region of Pasteurella Multocida Toxin (2008)

Pasteurella multocida toxin (PMT) is one of virulence factors responsible for the pathogenesis in some Pasteurellosis. We determined the crystal structure of the C-terminal region of PMT (C-PMT), which carries an intracellularly active moiety. The overall structure of C-PMT displays three different domains designated C1, C2 and C3. We found in the C3 domain the Cys-His-Asp catalytic triad that is organized only when the Cys is released from a disulfide bond. The steric alignment of the triad corresponded well to that of papain or other enzymes carrying the Cys-His-Asp triad. Our results demonstrate that PMT is an enzymatic toxin carrying the cysteine-protease like catalytic triad, which is organized only under reducing conditions.
Dynamical control of orbital occupations via a ferroelectric-induced polar state in metallic manganites (2013)

The breaking of orbital degeneracy on a transition metal cation and the resulting unequal electronic occupations of these orbitals provide a powerful lever over electron density and spin ordering in metal oxides. Here, we show how to dynamically modulate the orbital populations on Mn atoms at ferroelectric/manganite interfaces by switching the ferroelectric polarization. The change in orbital occupation can be as large as 10\%, greatly exceeding that of bulk manganites. This flippable orbital splitting is in large part controlled by the propagation of ferroelectric polar displacements into the interfacial region, a structural motif absent in the bulk and unique to the interface. We use {\it ab initio} theory, epitaxial thin film growth, and scanning transmission electron microscopy to verify the predicted interfacial polar state and concomitant orbital splittings.
Genetic Algorithm Based Robust and Optimal Path Planning for Sample-Return Mission from an Asteroid on an Earth Fly-By Trajectory (2015)

In this study, an interplanetary space flight mission design is established to obtain the minimum \(ΔV\) required for a rendezvous and sample return mission from an asteroid. Given the initial (observed) conditions of an asteroid, a (robust) genetic algorithm is implemented to determine the optimal choice of \(ΔV\) required for the rendezvous. Robustness of the optimum solution is demonstrated through incorporated bounded-uncertainties in the outbound \(ΔV\) maneuver via genetic fitness function. The improved algorithm results in a solution with improved robustness and reduced sensitivity to propulsive errors in the outbound maneuver. This is achieved over a solution optimized solely on \(ΔV\), while keeping the increase in \(ΔV\) to a minimum, as desired. Outcomes of the analysis provide significant results in terms of improved robustness in asteroid rendezvous missions.