gebhart/patrepeval huggingface dataset:
Plant Toxins (1987)

Journal Article Plant Toxins Get access Samuel W Page Samuel W Page Food and Drug Administration, Division of Contaminants Chemistry, Washington, DC 20204 Search for other works by this author on: Oxford Academic Google Scholar Journal of Association of Official Analytical Chemists, Volume 70, Issue 2, 1 March 1987, Pages 284–285, https://doi.org/10.1093/jaoac/70.2.284 Published: 22 January 2020
Energy flow in manganese-neodymium-doped fluoride glasses (1994)

Measurement of the time-response of the excited-state concentration of manganese and neodymium has confirmed our previous hypothesis of fast energy transfer between donors and acceptors in fluoride glasses.
Evaluation of Multi-Hop Packet Prioritization for Decentralized Congestion Control in VANETs (2017)

Decentralized congestion control (DCC) in ITS-G5 based vehicular ad hoc networks ensures that the requirements of safety and traffic efficiency applications are met even under high vehicle density and channel load conditions. In European standardization, a "gatekeeper" on top of the ITS-G5 MAC sub-layer is being considered that controls a node's packet rate as a function of the channel load. This paper studies the performance of the gatekeeper with packet prioritization and an adaptive linear control algorithm. The simulation results indicate that the gatekeeper with priority queuing (PQ) can effectively handle different packet priorities for multi-hop packets. Our gatekeeper-specific enhancements of the forwarding algorithm yield performance improvements in terms of reliability and latency compared to the plain DCC approach. Finally, we discuss the issue of packet starvation caused by the gatekeeper's PQ scheme that affects the performance of lower-priority packets.
ChemInform Abstract: Neighboring Group Participation in Organometallic Chemistry: Internal Exchange in (Diarylalkane)tricarbonylchromium Complexes. (1987)

Abstract Complexation of a phenyl group of the arenes (I) by a Cr(CO) 3 moiety to yield (III) causes an upfield shift in both aromatic and benzylic protons associated with the complexed ring, as well as a lowered acidity for these protons vs.
Hypocholesterolemic action of beta-cyclodextrin and its effects on cholesterol metabolism in pigs fed a cholesterol-enriched diet. (1997)

To examine the effects of beta-cyclodextrin (BCD), a non-absorbable carbohydrate, on lipid metabolism, growing pigs were fed a 0.3% cholesterol-enriched diet for 4 weeks or this diet containing 5% or 10% BCD. Pigs fed a basal diet without added cholesterol or BCD were used as controls. The cholesterol-rich diet induced hypercholesterolemia (1.75 vs. 0.84 g/l plasma) due to increased LDL concentration, delayed the plasma clearance of vitamin A, enhanced liver cholesterol storage, lowered the hepatic activities of LDL-receptors (by 47%) and HMG-CoA reductase (by 62%), stimulated cholesterol 7alpha-hydroxylase (x3), and accelerated the fecal output of neutral sterols (x4). Addition of BCD to the cholesterol-rich diet prevented the elevation of plasma cholesterol due to dietary cholesterol excess. Moreover, BCD produced a dose-dependent effect in reducing liver cholesterol storage, stimulating hepatic cholesterogenesis, increasing the proportion of primary bile acids in bile and in feces, and the fecal loss of neutral sterols and bile acids. Pigs receiving 10% BCD thus differed markedly from controls, especially for HMG-CoA reductase and cholesterol 7alpha-hydroxylase hepatic activities (x5), and fecal output of total bile acids (x3) and hyocholic acid (x20), and their overall cholesterol synthesis was higher (+50%), despite the abundant dietary cholesterol. Owing to the property of BCD to bind cholesterol and bile acids in vitro, these results suggest that this resistant carbohydrate accelerates body cholesterol turnover by reducing cholesterol absorption, increasing cholesterol and bile acid synthesis, and altering the action of the intestinal microflora.
Mesenchymal Stem Cells: Advances and Surgical Applications (2013)

Mesenchymal stem cells (MSCs) are used in regenerative medicine mainly based on their capacity to differentiate into specific cell types and also as bioreactors of soluble factors that will promote tissue regeneration from the damaged tissue cellular progenitors. Moreover, MSCs can stop a variety of immune cell functions: cytokine secretion and cytotoxicity of T and NK cells; B cell maturation and antibody secretion; DC maturation and activation; as well as antigen presentation. In this scenario, an inflammatory environment seems to be necessary to promote their effect. Preclinical studies have been conducted in rodents, rabbits and baboon monkeys among others for bone marrow, skin, heart, and corneal transplantation, graft-vs.-host disease, hepatic and renal failure, lung injury, multiple sclerosis, rheumatoid arthritis, and diabetes and lupus diseases. Preliminary results from some of these studies have led to human clinical trials; prevention of allograft rejection and enhancement of the survival of bone marrow and kidney grafts.
Accelerating the dynamic time warping distance measure using logarithmetic arithmetic (2014)

This paper describes an application-specific embedded processor with instruction set extensions (ISEs) for the Dynamic Time Warping (DTW) distance measure, which is widely used in time series similarity search. The ISEs in this paper are implemented using a form of logarithmic arithmetic that offers significant performance and power/energy advantages compared to more traditional floating-point operations.
Table S3 from Pembrolizumab Plus Pegylated Interferon alfa-2b or Ipilimumab for Advanced Melanoma or Renal Cell Carcinoma: Dose-Finding Results from the Phase Ib KEYNOTE-029 Study (2023)

&lt;p&gt;Treatment-Related Adverse Events Occurring in {greater than or equal to}1 Patient Treated With Pembrolizumab plus Ipilimumab&lt;/p&gt;
Cold Spray Deposition on Inner Side of Pipe with Aid of Radial Supersonic Nozzle (2014)

Abstract This work evaluates a new cold-spray technique for coating the inner surface of pipes. Rather than rotate the pipe as in previous methods, a radial supersonic nozzle is translated along the pipe axis, leaving behind a continuous coating. In a demonstration, the new method is used to apply aluminum, copper, and nickel coatings inside steel and aluminum pipes with inner diameters of 45-100 mm.
Insights into MnAl-C nano-twin defects by micromagnetic characterization (2021)

MnAl-C is a prominent candidate for the replacement of rare earth magnets with a moderate energy density product. Crystallographic defects have a strong effect on magnetization properties. In this work, we show the influence of twinning defects in the nanometer regime on the quality of the magnet. Standard micromagnetic simulations and computations of the saddle point configuration for magnetization reversal highlight the importance of optimizing the fraction of and reducing the width of crystallographic twin defects. Switching field distributions and the maximum possible coercive field for ideal microstructures without defects are estimated using a reduced order micromagnetic model.
Impact of tillage intensity on clay loam soil structure (2019)

Abstract Soil structure and structural stability are key parameters in sustainable soil management and optimum cropping practices. This study aimed to improve the knowledge of potential precision tillage practices by characterizing the effect of varied tillage intensities on structural properties of a clay loam soil. An experiment with seedbed preparation was conducted using a power take‐off‐driven rotovator equipped to measure torque and angular velocity and with operational speed ( OS ) and rotational speed ( RS ) as main factors. Effects of soil coverage prior to tillage and wheeling directly after tillage were measured at one combination of OS and RS . The soil was sampled at 0–80 mm depth. Under slow OS (2.9 km hr −1 ) compared with fast OS (6.3 km hr −1 ), specific energy input was greater (116 and 52 J kg −1 on average, respectively), and it increased with RS . Wheeling resulted in larger aggregate diameter right after tillage (at T1; 56 mm as geometric mean compared with 9 mm), with 42 times smaller geometric mean of air permeability 45 days after tillage (at T2) and with greater soil dispersibility at T2. Highly significant correlations were observed between soil dispersibility and energy input, specific surface area of aggregates, fractions of small (&lt;4 mm) and medium (8–16 mm) aggregates, and geometric mean diameter. Slow OS combined with fast RS showed significantly greater air permeability than all other treatments. The results suggest that there is a potential for controlling soil structure in seedbed preparation by minimizing compaction from traffic and adapting site‐specific control of rotovation intensity.
5A11/Basigin Gene Products Are Necessary for Proper Maturation and Function of the Retina (2004)

5A11/Basigin gene products are important membrane glycoproteins for development and maturation of the retina. The gene encodes two immunoglobulin-like, membrane-bound glycoproteins as a result of splice variation. The smaller protein product, named 5A11/Basigin, is expressed by many tissues within the mouse, whereas the larger protein product, named 5A11/Basigin-2, is expressed only by the photoreceptor cells (PCs) of the retina. Mice in which the gene for 5A11/Basigin has been deleted have several abnormalities, including blindness from the time of eye opening with subsequent degeneration of the PCs. Studies by this laboratory suggest that a developmental deficiency is the underlying cause of the blindness. However, definitive biological functions for 5A11/Basigin and 5A11/Basigin-2 have yet to be defined. It is known that 5A11/Basigin is multifunctional and can interact with several different proteins. Preliminary studies indicate that 5A11/Basigin-2 may be multifunctional as well. Studies by this laboratory and others have demonstrated that 5A11/Basigin (and probably 5A11/Basigin-2) acts as a chaperone for monocarboxylate transporter-1 (MCT-1) translocation to the cell membrane. We have proposed that a lactate metabolon exists within the retina and functions to shuttle lactate, an energy source, from glial cells to the PCs. This metabolon is not present within 5A11/Basigin null mouse retinas, which may be the underlying cause of the retinal dysfunction and subsequent degeneration. Further studies will be necessary to determine which of the functions are critical for proper development of the retina.
Lab-on-a-chip technologies for proteomic analysis from isolated cells (2008)

Lab-on-a-chip systems offer a versatile environment in which low numbers of cells and molecules can be manipulated, captured, detected and analysed. We describe here a microfluidic device that allows the isolation, electroporation and lysis of single cells. A431 human epithelial carcinoma cells, expressing a green fluorescent protein-labelled actin, were trapped by dielectrophoresis within an integrated lab-on-a-chip device containing saw-tooth microelectrodes. Using these same trapping electrodes, on-chip electroporation was performed, resulting in cell lysis. Protein release was monitored by confocal fluorescence microscopy.
Preparation of hydroxyapatite/poly(vinyl alcohol) composite film with uniformly dispersed hydroxyapatite particles using citric acid (2007)

Abstract Biocompatible hydroxyapatite (HA)/poly(vinyl alcohol) (PVA) composites and their transparent films were prepared by the coprecipitation and solvent casting method. The formation of HA in PVA composite powder was confirmed by the characteristic phosphate bands at 1100–1032 and 565 cm −1 at FT‐IR spectra, and the weight ratio of HA to PVA was 50/50 examined by TGA. The crystal melting temperature of HA/PVA decreased compared with that of pure PVA. HA/PVA (50/50) composite powder and pure PVA were dissolved in dimethyl sulfoxide to obtain a film with HA/PVA weight ratio of 10/90. To improve HA particles' dispersity, which is one of the major factors affecting the mechanical properties of composite materials, various contents of citric acid were used for the preparation of HA/PVA films. At a citric acid concentration of 5 wt %, HA/PVA film with good dispersity of HA particles was obtained. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci, 2007
Survivorship care planning in skin cancer: An unbiased statistical approach to identifying patterns of care‐plan use (2017)

With a convenience sample of skin cancer survivors, it is possible to model factors that predict the receipt of SCPs. Important variables include the diagnosis age, treatment setting, physician type, and treatment-summary utilization. A closer examination of these variables identified several disparities in care-plan use and, therefore, opportunities to improve the distribution of SCPs. Further validation in additional cohorts of survivors is necessary to confirm these conclusions. Cancer 2018;124:183-91. © 2017 American Cancer Society.
State-of-the-Art: Biodesign based Innovation Ecosystems in Europe (2021)

Abstract Today's healthcare challenges with unmet clinical needs, high regulation and certification standards, and increasing costs demand faster innovation and technical translation. To address this challenge, Stanford released a fellowship called Biodesign, where need-based healthcare innovation is taught with the approach identify, invent and implement. Since then, different European institutions have adopted the Biodesign innovation approach and organized within the Biomedical Engineering- Innovation, Design, and Entrepreneurship Alliance (BMEidea EU). The generation of successful healthcare innovation isn't only based on participating in an Innovation teaching program. It is much more a matter of having the right innovation ecosystem with an open creative mindset, experts, the respective stakeholders, and access to essential resources within reach (close to clinic). Through a qualitative survey, seven Biodesign based teaching programs in the EU were examined. The study from an academic perspective contains information covering Resources, Activities, Academic Performance, and Transfer Performance. The demand for new healthcare innovations, and especially innovation training programs that address challenges, developed collaboratively with the respective stakeholders, is increasing. Additionally, there is a growing expectation that innovation needs to reach the market quickly and be implemented accordingly. A Healthcare Innovation Ecosystem, where different entities function as a productive unit with a shared vision and committed to application-driven research and technology transfer, will increase innovation's success and adaptation.
Expression Analysis ofArabidopsis thalianaSmall Secreted Protein Genes (2012)

Small proteins secreted to the extracellular matrix in plants regulate many physiological activities, including pathogen response, material transport, and morphogenesis, but the functions of most small secreted proteins have not been elucidated except for some well-known small secreted proteins. To predict the functions and physiological roles of unidentified small secreted proteins, information on their expression patterns is valuable. Here, we report expression analysis of Arabidopsis thaliana small secreted protein (ATSP) genes that encode proteins possessing a signal peptide at N-terminal, and protein sizes were less than 100 amino acid residues. By promoter:reporter experiments, we examined the expression of 122 ATSPs, including 47 unannotated ATSPs that do not have any discernable motifs, in tissues and at the cellular level in Arabidopsis seedlings, and floral organs. As a result, 79 ATSP genes were expressed in various regions of the seedlings, and 37 ATSP genes were specifically expressed.
Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766) (2017)

Demonstrating intracellular protein target engagement is an essential step in the development and progression of new chemical probes and potential small molecule therapeutics. However, this can be particularly challenging for poorly studied and noncatalytic proteins, as robust proximal biomarkers are rarely known. To confirm that our recently discovered chemical probe 1 (CCT251236) binds the putative transcription factor regulator pirin in living cells, we developed a heterobifunctional protein degradation probe. Focusing on linker design and physicochemical properties, we generated a highly active probe 16 (CCT367766) in only three iterations, validating our efficient strategy for degradation probe design against nonvalidated protein targets.
ChemInform Abstract: SYNTHESIS OF NEW ALIPHATIC COMPLEXONS AND STUDY OF THE MECHANISM OF ACIDIC DISSOCIATION (1985)

Abstract Aus Ethanolamin (I) wird durch Alkylierung mit Natriumchloracetat (II) und anschließende oxidative Desalkylierung das N‐Hydroxyethyl‐glycin (IV) hergestellt.
A high-performance wear-leveling algorithm for flash memory system (2012)

In this paper, a low-complexity high-performance wear-leveling algorithm which named sequential garbage collection (SGC) for flash memory system design is presented. The proposed SGC outperforms existing designs in terms of wear evenness and low design complexity. The lifetime of the flash memory can be greatly lengthened by the proposed SGC. The proposed SGC doesn’t require any tuning threshold parameter, and thus it can be applied to various systems without prior knowledge of the system environment for threshold tuning. Simulation results show that the maximum block erase count and standard deviation of the block erase count compared to the greedy algorithm are decreased by up to 75% and 94%, respectively.
Learning from Northern clingfish (Gobiesox maeandricus): bioinspired suction cups attach to rough surfaces (2019)

While artificial suction cups only attach well to smooth surfaces, the Northern clingfish can attach to surfaces ranging from nanoscale smooth to rough stone. This ability is highly desirable for technical applications. The morphology of the fish's suction disc and its ability to attach to rough and slimy surfaces have been described before, and here we aim to close gaps in the biomechanical understanding, and transfer the biomechanical principles to technical suction cups. We demonstrate that the margin of the suction disc is the critical feature enabling attachment to rough surfaces. Second, friction measurements show that friction of the disc rim is increased on rough substrates and contributes to high tenacity. Increased friction causes a delay in failure of the suction cup and increases the attachment force. We were able to implement these concepts to develop the first suction cups bioinspired by Northern clingfish. These cups attach with tenacities up to 70 kPa on surfaces as rough as 270 µm grain size. The application of this technology is promising in fields such as surgery, industrial production processes and whale tagging. This article is part of the theme issue 'Transdisciplinary approaches to the study of adhesion and adhesives in biological systems'.
The Influence of the Gate Driver and Common-Source Inductance on the Short-Circuit Behavior of IGBT Modules and Protection (2020)

In this article, the influence of the gate drive unit on the short-circuit (SC) type II and III behavior of insulated gate bipolar transistor (IGBT) modules was investigated in detail. It is found that the real gate voltage of the IGBT chip contacts cannot be measured across the auxiliary pins of a power module. The difference between applied gate voltage at the sense contacts and the real gate voltage at the IGBT gate contact is shown to be highly dependent on the common-source inductance and hence, the packaging concept. The value of the gate resistance has a significant effect on SC behavior. A gate voltage self-clamping effect during SC was found and verified with the help of circuit simulation. Finally, a gate voltage clamping circuit for improved SC ruggedness of the IGBT modules is introduced. Based on the clamping circuit, a new fast SC type II and III detection method is developed and tested, which can detect and turn-off the SC event within 400 ns.
The ability of spore formers to degrade milk proteins, fat, phospholipids, common stabilizers, and exopolysaccharides (2019)

Spore formers are common spoilage-causing microorganisms in dairy products; however, their modes of spoilage (proteolysis, lipolysis, etc.) have not been described in detail for cultured dairy products such as sour cream and yogurt. The objective of the present study was to test the ability of spore-forming strains isolated from dairy environments for their spoilage-causing activities at typical sour cream (24°C) and yogurt (42°C) fermentation temperatures. A total of 25 spore-forming strains were isolated from different sources, including raw milk, pasteurizer balance tank, biofilms formed on heat exchangers, and milk powder. These strains were tested for proteolytic and lipolytic activities and for their ability to degrade phospholipids, common stabilizers (starch, gelatin, xanthan gum, pectin), and exopolysaccharides (EPS) at sour cream and yogurt fermentation temperatures. A higher percentage of positive strains was observed for selected activities at yogurt fermentation temperature compared with sour cream fermentation temperature. Identified proteolytic spore-forming strains, based on a skim milk agar method, were subsequently quantified for their level of proteolysis using non-casein nitrogen (NCN) content and sodium dodecyl sulfate-PAGE (SDS-PAGE). The proteolytic strains that showed the highest levels of proteolysis (highest percentages of NCN content) at 24°C were Bacillus mojavensis BC, Bacillus cereus DBC, Bacillus subtilis DBC, B. mojavensis DBC1, and Paenibacillus polymyxa DBC1. At 42°C the strains with the highest levels of proteolysis (highest percentages of NCN content) were B. subtilis DBC, B. mojavensis BC, B. mojavensis DBC1, B. cereus DBC, and Bacillus licheniformis DBC6. Results of SDS-PAGE demonstrated that proteolytic strains had primarily hydrolyzed β- and κ-CN. A viscometric method was used to evaluate the susceptibility of exopolysaccharides (EPS) to degradation by selected spore formers. This method helped to determine that EPS produced by commercial yogurt and sour cream cultures is susceptible to degradation by spore formers present in dairy environments.
Effect of Heat Treatment on Peel Strength of 16Cr-Ferritic Stainless Steel / Aluminum Rolled Clad Sheet and Proposed Joint Mechanism (2018)

The peel strength of 16Cr-ferritic stainless steel / aluminum rolled clad sheet is improved by heat treatment at 300 to 500 °C after clad rolling. The joint mechanism was studied by analyzing the fracture surface after the peel test, taking into account the characteristics of the peel test method.
Successful Management of a Patient With X-Linked Myotubular Myopathy for Scoliosis Surgery and Previous Cardiac Arrest After Prone Positioning: A Case Report (2018)

A 15-year-old boy with X-linked myotubular myopathy associated with severe hypotonia and pectus excavatum presented for posterior spinal fusion of T2-sacrum because of rest pain and severe progressive neuromuscular scoliosis. Previously, he experienced 2 separate instances of cardiac arrest after prone positioning under general anesthesia. A preoperative computed topography angiogram in the supine and prone positions revealed inferior vena cava and right ventricular outflow tract obstruction on prone positioning. Successful positioning and posterior spinal fusion occurred by staging the procedure, correction of volume status, early use of vasoactive and inotropic agents, and oblique prone positioning.