gebhart/patrepeval huggingface dataset:
Targeting brain regions of interest in functional near‐infrared spectroscopy—Scalp‐cortex correlation using subject‐specific light propagation models (2021)

Targeting specific brain regions of interest by the accurate positioning of optodes (emission and detection probes) on the scalp remains a challenge for functional near-infrared spectroscopy (fNIRS). Since fNIRS data does not provide any anatomical information on the brain cortex, establishing the scalp-cortex correlation (SCC) between emission-detection probe pairs on the scalp and the underlying brain regions in fNIRS measurements is extremely important. A conventional SCC is obtained by a geometrical point-to-point manner and ignores the effect of light scattering in the head tissue that occurs in actual fNIRS measurements. Here, we developed a sensitivity-based matching (SBM) method that incorporated the broad spatial sensitivity of the probe pair due to light scattering into the SCC for fNIRS. The SCC was analyzed between head surface fiducial points determined by the international 10-10 system and automated anatomical labeling brain regions for 45 subject-specific head models. The performance of the SBM method was compared with that of three conventional geometrical matching (GM) methods. We reveal that the light scattering and individual anatomical differences in the head affect the SCC, which indicates that the SBM method is compulsory to obtain the precise SCC. The SBM method enables us to evaluate the activity of cortical regions that are overlooked in the SCC obtained by conventional GM methods. Together, the SBM method could be a promising approach to guide fNIRS users in designing their probe arrangements and in explaining their measurement data.
Local delivery of mitoxantrone for the treatment of malignant brain tumors in rats (2002)

These findings establish that mitoxantrone delivered from intracranially implanted biodegradable wafers is effective in the treatment of malignant gliomas in rodents and should be considered for future clinical application in humans.
Neuronal ion channels and their sensitivity to extremely low frequency weak electric field effects (2003)

Neuronal ion channels are gated pores whose opening and closing is usually regulated by factors such as voltage or ligands. They are often selectively permeable to ions such as sodium, potassium or calcium. Rapid signalling in neurons requires fast voltage sensitive mechanisms for closing and opening the pore. Anything that interferes with the membrane voltage can alter channel gating and comparatively small changes in the gating properties of a channel can have profound effects. Extremely low frequency electrical or magnetic fields are thought to produce, at most, microvolt changes in neuronal membrane potential. At first sight, such changes in membrane potential seem orders of magnitude too small to significantly influence neuronal signalling. However, in the central nervous system, a number of mechanisms exist which amplify signals. This may allow such small changes in membrane potential to induce significant physiological effects.
Polymer Drugs and Polymeric Drugs, Part VII*: Antitumor Conjugated Polymeric Drugs Consisting of 5-Fluorouracil and Polyanionic Polymers (1990)

Derivatives of 5-flurorouracil 1-N-p-vinylbenzoyl-5-fluorouracil (VBFU) were prepared and the solvolysis rates were determined and compared with other 1-N-substituted 5-fluorouracils. VBFU was homopolymerized and copolymerized with maleic anhydride or poly(ethylene glycol) macromonomer. The hydrolysis of these polymeric drugs was studied in a phosphate buffer solu tion, and in vivo antitumor activity was evaluated using Ehrlich's ascites or Sarcoma 180 tumor-bearing mice.
Convenient Synthesis and Biological Evaluation of Modafinil Derivatives: Benzhydrylsulfanyl and Benzhydrylsulfinyl [1,2,3]triazol-4-yl-methyl Esters (2011)

Simple synthesis and biological activities of modafinil derivatives are described. The key reactions include condensation of acid and propargyl alcohol, subsequent 1,3-dipolar cycloaddition reaction of alkynes and (3-azido-propyl)cyclohexane or (4-azido-butyl)benzene in the presence of sodium ascorbate and CuSO₄·5H₂O in excellent yield. They were then evaluated for the suppression of LPS-induced NO generation in vitro. It was found that all compounds showed moderate effects for suppression of LPS-induced NO generation.
Reachability analysis for neural feedback systems using regressive polynomial rule inference (2019)

We present an approach to construct reachable set overapproximations for continuous-time dynamical systems controlled using neural network feedback systems. Feedforward deep neural networks are now widely used as a means for learning control laws through techniques such as reinforcement learning and data-driven predictive control. However, the learning algorithms for these networks do not guarantee correctness properties on the resulting closed-loop systems. Our approach seeks to construct overapproximate reachable sets by integrating a Taylor model-based flowpipe construction scheme for continuous differential equations with an approach that replaces the neural network feedback law for a small subset of inputs by a polynomial mapping. We generate the polynomial mapping using regression from input-output samples. To ensure soundness, we rigorously quantify the gap between the output of the network and that of the polynomial model. We demonstrate the effectiveness of our approach over a suite of benchmark examples ranging from 2 to 17 state variables, comparing our approach with alternative ideas based on range analysis.
Interactions of Enamel Matrix Derivative and Biomechanical Loading in Periodontal Regenerative Healing (2011)

These in vitro findings suggest that the beneficial actions of EMD on PDL cell functions critical for periodontal regeneration are jeopardized by biomechanical loading. Clinical studies should clarify whether protection of teeth against occlusal forces in the early healing stage may positively affect the outcome of regenerative therapy with EMD.
Ceramic total hip arthroplasty in the United States: safety and risk issues revisited. (2008)

The advantages of all-alumina bearings are superb wear resistance, stability, and inertness demonstrated over 3 decades. The disadvantage is a small risk for brittle fracture, as described in this paper. Surveying the latest ceramic hip series reported in recent journal articles or presented at the 6th World Biomaterials Congress, we found 11 studies representing more than 35,000 cases followed for 3 to 25 years. There were 24 reported fractures. A unique survey of hip complications in the 1990s found a fracture risk of approximately 1.4 per 1000 ceramic balls used in the United States. A company database holding more than 2.5 million records described the overall fracture risk as 1 per 10,000 cases. Initial use of ceramic cup inserts indicated a 2% to 3% incidence of chipping during surgery. Beginning in 1997, the number of ceramic-metal cup-locking cases entered into a US Food and Drug Administration ceramics database was more than 2400, with no fractures reported by the FDA in July 2003.
Efficient computation of distance incorporated codon autocorrelation (DICA) score using fast Fourier transform (2015)

The availability of synonymous codons (codons that can translate the same amino acid into protein) enables a protein to be encoded by many different sequences of codons/tRNAs. Autocorrelation measures the reuse of a particular codon/tRNA in succession (instead of choosing a different synonymous one) during the translation of a protein sequence. Studies show that tRNA autocorrelation in a coding sequence has important effects on its translation speed.
Structural features of a polygalacturonase gene cloned from Aspergillus oryzae KBN616 (1993)

A genomic gene encoding a polygalacturonase from Aspergillus oryzae, used in soy sauce production, was cloned and sequenced. The structural gene comprises 1227 bp coding for 363 amino acids with a putative prepropeptide of 28 amino acids and the open reading frame is disrupted by two short introns of 57 bp and 81 bp. The deduced amino acid sequence of the mature protein showed 63, 63, 63 and 64% homology with those of Aspergillus niger polygalacturonase I, Aspergillus niger polygalacturonase II, Aspergillus tubingensis polygalacturonase II and Cochliobolus carbonum polygalacturonase, respectively. There is, however, little homology among fungal, plant and bacterial polygalacturonases.
Synthesis and Electrospinning of Polycaprolactone from an Aluminium-Based Catalyst: Influence of the Ancillary Ligand and Initiators on Catalytic Efficiency and Fibre Structure (2019)

In the present study, we investigated the catalytic performance of a 2,2′-methylenebis(6-tert-butyl-4-methylphenol) (MDBP)–aluminium complex for the ring-opening polymerisation (ROP) of ε-caprolactone in combination with various alcohols as initiators. Three different alcohols were investigated: 1-adamantanemethanol (A), 1H,1H,2H,2H-perfluoro-1-octanol (F) and isopropanol (I). Samplings of polycaprolactone (PCL) at various reaction times showed a linear increase in the polymer molecular weight with time, with very narrow polydispersity, confirming the living nature of the catalytic system. Scanning electron microscope (SEM) images of electrospun PCL fibre mats produced from 30 wt % dichloromethane/dimethyl sulfoxide solutions showed a high level of surface porosity with a reasonable homogeneity of fibre diameters. The values of the liquid absorption and water contact angle were measured for the electrospun mats, with the F-capped PCL consistently showing absorption values up to three times higher than those of PCL samples capped with the other two alcohols, as well as increased hydrophobicity. The nature of the alcohol can influence the surface hydrophobicity and absorption ability of electrospun fibres, demonstrating the possibility of tailoring material properties through controlled polymerisation.
A flexible system-on-a-chip implementation of the Advanced Encryption Standard (2016)

Systems-on-a-Chip are among the best-performing and complete solutions for complex electronic systems. This is also true in the field of network security, an application requiring high performance with low resource usage. This work presents an Advanced Encryption Standard implementation for Systems-on-a-Chip using as a reference the Cipher Block Chaining mode. In particular, a flexible interface based and the Advanced Peripheral Bus to integrate the encryption algorithm with any kind of processor is presented. The hardware-software approach of the architecture is also analyzed and described. The final system was integrated on a Xilinx Zynq 7000 to prototype and evaluate the idea. Results show that our solution demonstrates good performance and flexibility with low resource usage, occupying less than 2% of the Zynq 7000 with a throughput of 320 Mbps. The architecture is suitable when implementations of symmetric encryption algorithms for modern Systems-on-a-Chip are required.
Lärm und Herz-Kreislauf-Erkrankungen (2021)

Zusammenfassung Umgebungslärm stellt einen bedeutsamen umweltbezogenen Risikofaktor für die öffentliche Gesundheit dar. Die Europäische Umweltagentur gibt an, dass mindestens 20% der europäischen Bevölkerung schädlichen Tag-Abend-Nacht-Lärmpegeln von 55 Dezibel (dB) ausgesetzt sind, wobei die Weltgesundheitsorganisation zum Schutz der Bevölkerung, abhängig von der Lärmquelle, bis zu 10 dB tiefere Grenzwerte empfiehlt. Chronischer Lärm kann mit alltäglichen Aktivitäten und dem Schlaf interferieren und mentale sowie physiologische Stressreaktionen auslösen, die langfristig das Risiko für Herz-Kreislauf-Erkrankungen erhöhen können. Daher sind zwingend präventive Maßnahmen an der Quelle inklusive lärmreduzierender bautechnischer Veränderungen notwendig, um die Einhaltung von Lärmgrenzwerten zu gewährleisten und die Bevölkerung vor den negativen gesundheitlichen Auswirkungen des Lärms zu schützen.
Imaging with Phasor Fields for Non-Line-of Sight Applications (2018)

A mathematical construct ‘Phasor Fields’ (P-Fields) is used to develop a light transport mathematical model for non-line-of-sight (NLOS) imaging applications. We show that NLOS imaging can be treated as conventional line-of-sight (LOS) imaging using P-Fields.
Noninvasive Helicobacter pylori Testing for the "Test-and-Treat" Strategy (2001)

Active testing for H pylori infection significantly decreases the inappropriate use of antimicrobial therapy when compared with antibody testing. The advantages of active testing should be enhanced as the widespread use of antimicrobial agents increases the proportion of patients with antibody to H pylori, but without active infection.
THE EFFECT OF SALT, WATER AND TEMPERATURE ON WHEAT DOUGH RHEOLOGY (2007)

ABSTRACT In this study the effect of salt, water and temperature on dough rheology was modeled. Surface response methodology (D‐Optimal mode) was used in order to quantify and estimate any nonlinearity in the relationships between the parameters under study. Each variable had five levels: salt (0, 1, 2, 3, 4%), water (50, 56, 62, 68, 74%), temperature (20, 25, 30 35, 40C). Temperature, added water and salt level all had significant effects on consistency, hydration and total energy as measured by a farinograph. Addition of salt caused a decrease in consistency and total energy but increased the hydration time in particular at low water levels. The effect of salt on hydration was related to its competition with flour in water absorption. The effect of added water on consistency, hydration and total energy was negative. Added water softens the dough and decreases the hydration time and the energy required for mixing. Temperature increase had a negative effect on consistency, hydration time and total energy. Salt reduction affects the mixing process of the ingredients of dough formulation. In total, the effect of salt was low compared with temperature and added water. Using the models obtained and reported in this research, the effect of dough can be compensated by other parameters such as temperature and added water level. The models presented in this article enable the reader to play with the parameters quantitatively. PRACTICAL APPLICATIONS One of the ways of solving the technological problems of reduced‐salt dough and bread is to change the temperature and added water level of wheat flour dough. Using the equations presented in this article, it is possible to calculate the salt effect on consistency, hydration time and total energy of a dough formulation at a known temperature and added water level, e.g., if the salt level of a dough formulation changes from 2 to 1%, the changes required to other parameters (temperature and added water) to compensate the effect of salt can be obtained. This can have practical applications in the design of bread‐making equipments and in solving the technological problems of low‐salt breads.
Sensitive determination of aluminum in parenteral solutions and injections by HPLC with fluorescence detection using lumogallion (2004)

輸液及び注射剤等中のアルミニウム濃度の規制が，2004年に米国で開始されようとしている．本研究では，高感度なルモガリオン錯体の蛍光検出法による輸液及び注射剤等中の微量アルミニウムの測定法について検討した．ほとんどの製剤において前処理を必要とせず，回収率及び直線性共に良好な結果が得られた．また，製剤の原料成分に関しても同様の結果が得られた．生体試料の測定として尿及び血清中のアルミニウム濃度の測定を行い，尿は前処理を必要とせず，血清は酸添加及び遠心分離のみの前処理で測定可能であった．このように本測定法の測定対象は広範囲であり，かつ製剤中の1 μg/l以下のアルミニウムが測定可能である．
Metal homoenolate chemistry. Isolation and reactions of titanium homoenolates of esters (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMetal homoenolate chemistry. Isolation and reactions of titanium homoenolates of estersEiichi Nakamura and Isao KuwajimaCite this: J. Am. Chem. Soc. 1983, 105, 3, 651–652Publication Date (Print):February 1, 1983Publication History Published online1 May 2002Published inissue 1 February 1983https://pubs.acs.org/doi/10.1021/ja00341a071https://doi.org/10.1021/ja00341a071research-articleACS PublicationsRequest reuse permissionsArticle Views553Altmetric-Citations55LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Lattice-Based Anomaly Rectification for Sport Video Annotation (2010)

Anomaly detection has received much attention within the literature as a means of determining, in an unsupervised manner, whether a learning domain has changed in a fundamental way. This may require continuous adaptive learning to be abandoned and a new learning process initiated in the new domain. A related problem is that of anomaly rectification; the adaptation of the existing learning mechanism to the change of domain. As a concrete instantiation of this notion, the current paper investigates a novel lattice-based HMM induction strategy for arbitrary court-game environments. We test (in real and simulated domains) the ability of the method to adapt to a change of rule structures going from tennis singles to tennis doubles. Our long term aim is to build a generic system for transferring game-rule inferences.
Synthesis, experimental andin silicostudies ofN-fluorenylmethoxycarbonyl-O-tert-butyl-N-methyltyrosine, coupled with CSD data: a survey of interactions in the crystal structures of Fmoc–amino acids (2020)

Recently, fluorenylmethoxycarbonyl (Fmoc) amino acids (e.g. Fmoc-tyrosine or Fmoc-phenylalanine) have attracted growing interest in biomedical research and industry, with special emphasis directed towards the design and development of novel effective hydrogelators, biomaterials or therapeutics. With this in mind, a systematic knowledge of the structural and supramolecular features in recognition of those properties is essential. This work is the first comprehensive summary of noncovalent interactions combined with a library of supramolecular synthon patterns in all crystal structures of amino acids with the Fmoc moiety reported so far. Moreover, a new Fmoc-protected amino acid, namely, 2-{[(9H-fluoren-9-ylmethoxy)carbonyl](methyl)amino}-3-{4-[(2-hydroxypropan-2-yl)oxy]phenyl}propanoic acid or N-fluorenylmethoxycarbonyl-O-tert-butyl-N-methyltyrosine, Fmoc-N-Me-Tyr(t-Bu)-OH, C<sub>29</sub>H<sub>31</sub>NO<sub>5</sub>, was successfully synthesized and the structure of its unsolvated form was determined by single-crystal X-ray diffraction. The structural, conformational and energy landscape was investigated in detail by combined experimental and in silico approaches, and further compared to N-Fmoc-phenylalanine [Draper et al. (2015). CrystEngComm, 42, 8047-8057]. Geometries were optimized by the density functional theory (DFT) method either in vacuo or in solutio. The polarizable conductor calculation model was exploited for the evaluation of the hydration effect. Hirshfeld surface analysis revealed that H...H, C...H/H...C and O...H/H...O interactions constitute the major contributions to the total Hirshfeld surface area in all the investigated systems. The molecular electrostatic potentials mapped over the surfaces identified the electrostatic complementarities in the crystal packing. The prediction of weak hydrogen-bonded patterns via Full Interaction Maps was computed. Supramolecular motifs formed via C-H...O, C-H...π, (fluorenyl)C-H...Cl(I), C-Br...π(fluorenyl) and C-I...π(fluorenyl) interactions are observed. Basic synthons, in combination with the Long-Range Synthon Aufbau Modules, further supported by energy-framework calculations, are discussed. Furthermore, the relevance of Fmoc-based supramolecular hydrogen-bonding patterns in biocomplexes are emphasized, for the first time.
An Effective K-Anonymity Clustering Method for Less Effectiveness on Accuracy of Data Mining Results (2011)

Data mining technology has interested in means of identifying patterns and trends from large collections of data. It is however evident that the collection and analysis of data that include personal information may violate the privacy of the individuals to whom data refers. The k-anonymity model is one of the most known novel privacy preserving approaches that have been extensively studied for the past few years. In this paper, effective approach that is used the idea of clustering for enforcing the k-anonymity is proposed; the goal of this approach is preserved privacy of data with less effectiveness on data mining results. A set of experiments were carried out on the database of the UC Irvine machine learning repository. The obtained results show that the proposed method keeps data privacy preservation with very low effect on accuracy of data mining results compared with greedy k-member and one pass k-means algorithms. Keywords: Data mining, privacy preserving data, k-anonymity, greedy k-member, one pass k-means.
Research of Network Storage Based on Data De-Duplication (2011)

Deduplication is a dedicated to reducing the amount of data to back up, maximize storage utilization, increase the time a new data backup technology. Introduced a variety of data de-duplication technology, describes the process of data de-duplication principle, analyze the same data and similar data detection detection technology differences. Proposed a content-based intelligent data deduplication model, and improved identification of a content-based data de-duplication algorithm. The model and improved algorithm can reduce the redelete technology caused by the accidental deletion of data loss, help build disaster recovery, increase backup storage capacity
Physics, fish and food (1982)

The physical properties of foods depend on many variables such as composition, temperature and history, and preservation processes depend in turn on these properties. This article looks at some areas of study which have provided insight into the physics of fish technology
Porosity of porcine small‐intestinal submucosa for use as a vascular graft (1993)

The porosity of a vascular graft material has been suggested as a major factor affecting the rate and degree of neovascularization of newly implanted grafts, with higher porosities generally associated with better performance. The objective of this study was to determine the water porosity of a new vascular graft material, small-intestinal submucosa (SIS), and to compare the values to those reported for other common vascular graft materials. In addition, the porosity of SIS was investigated with respect to applied pressure and applied uniaxial tension. Both rectangular, flat specimens and tubular specimens of SIS were subjected to static water pressure, and water was collected as it passed through the SIS material. SIS has a typical porosity of 0.52 mL/min.cm-2 at an applied pressure of 120 mm Hg. Although porosity appeared to be unaffected by uniaxial tension, it increased in proportion to applied pressure at a rate of 4.8 x 10(-3) mL/min.cm-2/mm Hg. These low porosity values and the past success of SIS as a vascular graft material suggest that high-porosity materials are not required for implant success.