gebhart/patrepeval huggingface dataset:
Tunnel magnetoresistance sensors with symmetric resistance-field response and noise properties under AC magnetic field modulation (2022)

Magnetoresistance (MR) devices with symmetric (even-function) resistance change to an external magnetic field is useful for various magnetic sensor applications, such as encoders for position and rotation detection and ultra-sensitive magnetic field sensors, when combined with a frequency modulation method. In this study, we developed tunnel magnetoresistance (TMR) sensors with even-function resistance–field (R–H) responses and investigated their noise properties. The developed TMR sensors achieved a higher MR ratio (∼120%) than those of conventional giant magnetoresistive multilayers exhibiting even-function R–H responses. The TMR sensors were realized by stabilizing the magnetization of the magnetic free layer (FL) in an anti-parallel configuration with respect to that of the reference layer. Orange-peel ferromagnetic coupling between the FL and a pinned layer through an AgSn spacer layer was used to control the strength of the unidirectional magnetic anisotropy of the FL, by which even-function R–H responses with negligible hysteresis were obtained. The sensors enabled us to study the intrinsic noise properties of TMR devices, particularly under an external AC modulation magnetic field. We found that the magnetic 1/f noise originating from thermal magnetization fluctuation was the dominant noise of the TMR sensors at low frequencies. We observed that the application of an AC modulation field to the TMR sensors increased the noise owing to the magnetic domain fluctuation and the transfer of magnetic 1/f noise to the modulation frequency.
Time resolved EUV pump-probe microscopy of fs-LASER induced nanostructure formation (2011)

We report on our efforts in design and construction of a compact Extreme Ultraviolet (EUV)-pump-probe microscope. The goal is the observation of formation of nanostructures, induced by a femtosecond (fs)-laser pulse. The unique interaction processes of fs-laser radiation with matter open up new markets in laser material processing and, therefore, are actively investigated in the last decade. The resulting "sub 100 nm"-structures offer vast potential benefits in photonics, biotechnology, tribological surface design, plasmonic applications and production of nanoparticles. Focused fs-laser radiation causes a local modification resulting in nanostructures of high precision and reproducibility. However the formation dynamics is not well understood. Research in this field requires high temporal and spatial resolution. A combination of fs-laser and EUV-microscope provides a tool for "in situ"-observation of the formation dynamics. As exemplary structures to be investigated, we use nanojets on thin gold films and periodic surface structures (ripples) on dielectrics. In the future, the EUV-pump-probe microscope can become a versatile tool to observe physical or biological processes. Microscopy using EUV-light is capable of detecting structures on a scale down to several tens of nanometers. For detailed investigations a compact EUV-microscope has been realized utilizing O<sup>VI</sup> Balmer-alpha radiation at 17.3 nm coming from a discharge produced oxygen plasma. As optical elements a grazing incidence elliptical collector and a zone plate with a width of outermost zone of 50 nm and a spectral filter to avoid chromatic aberrations are used. The detector is a fast gated microchannel plate with a pore size of 2 microns contacted by a low impedance transmission line. The expected spatial resolution of the setup is better than 100 nm and the time resolution is better than 1 ns. The newly developed EUV-microscope is a powerful tool for a wide field of investigations that need high time and spatial resolutions simultaneously.
The effect of losartan therapy on ventricular function in Marfan patients with haploinsufficient or dominant negative FBN1 mutations (2016)

Mild biventricular dysfunction is often present in patients with Marfan syndrome. Losartan has been shown to reduce aortic dilatation in patients with Marfan syndrome. This study assesses the effect of losartan on ventricular volume and function in genetically classified subgroups of asymptomatic Marfan patients without significant valvular regurgitation. In this predefined substudy of the COMPARE study, Marfan patients were classified based on the effect of their FBN1 mutation on fibrillin-1 protein, categorised as haploinsufficient or dominant negative. Patients were randomised to a daily dose of losartan 100 mg or no additional treatment. Ventricular volumes and function were measured by magnetic resonance imaging at baseline and after 3 years of follow-up. Changes in biventricular dimensions were assessed in 163 Marfan patients (48 % female; mean age 38 ± 13 years). In patients with a haploinsufficient FBN1 mutation (n = 43), losartan therapy (n = 19) increased both biventricular end diastolic volume (EDV) and stroke volume (SV) when compared with no additional losartan (n = 24): left ventricular EDV: 9 ± 26 ml vs. −8 ± 24 ml, p = 0.035 and right ventricular EDV 12 ± 23 ml vs. −18 ± 24 ml; p < 0.001 and for left ventricle SV: 6 ± 16 ml vs. −8 ± 17 ml; p = 0.009 and right ventricle SV: 8 ± 16 ml vs. −7 ± 19 ml; p = 0.009, respectively. No effect was observed in patients with a dominant negative FBN1 mutation (n = 92), or without an FBN1 mutation (n = 28). Losartan therapy in haploinsufficient Marfan patients increases biventricular end diastolic volume and stroke volume, furthermore, losartan also appears to ameliorate biventricular filling properties.
Distributed estimation over parallel fading channels with channel estimation error (2008)

We consider distributed estimation of a source observed by sensors in additive Gaussian noise, where the sensors are connected to a fusion center with unknown orthogonal (parallel) flat Rayleigh fading channels. We adopt a two-phase approach of (i) channel estimation with training, and (ii) source estimation given the channel estimates, where the total power is fixed. We prove that allocating half the total power into training is optimal, and show that compared to the perfect channel case, a performance loss of at least 6 dB is incurred. In addition, we show that unlike the perfect channel case, increasing the number of sensors will lead to an eventual degradation in performance. We characterize the optimum number of sensors as a function of the total power and noise statistics. Simulations corroborate our analytical findings.
The Visual Fields: A Textbook and Atlas of Clinical Perimetry, ed 3. (1971)

The first edition of Harrington's textbook,<i>The Visual Fields</i>, appeared in 1956 and filled a definite need in ophthalmology, neurology, and neurosurgery. It received almost immediate and well-deserved recognition. The third edition is most welcome and reflects continued demand for this book. It is a thorough and sensible compendium of useful knowledge concerning the techniques for obtaining visual fields and their diagnostic interpretation. The illustrations are exceptionally clear and cover the entire range of field abnormalities. The text is lucid and readable. The bibliography is adequate. The visual field examination is a significant part of the ophthalmic examination. It provides information obtainable in no other way and can provide essential clues to diagnosis. However, in my experience, it is generally poorly performed and poorly utilized. Part 1 of Dr. Harrington's book is a discussion of the examination of the visual field and is practical and sensible and will provide
Extending the Travel Range of Analog-Tuned (1999)

The pull-in instability limits the travel distance of elastically suspended parallel-plate electrostatic microactuators to about 1/3 of the undeflected gap distance. In this paper, we examine the and methods for extending the travel range of electrostatic actuators. The leveraged bending effect can be used to achieve full gap travel at the cost of increased actuation voltage. The strain-stiffening effect can be used to minimize actuation voltage for a given travel range. An analytical approximation shows that the strain- stiffening effect can be used to achieve a stable travel distance up to about 3/5 of the gap. A tunable reflective diffraction grating known as the polychromator has been designed using these actuation techniques, and selected designs have been fabricated and tested for actuation behavior. Gratings with 1024 flat, closely packed grating-element actuators have been fabricated with over 1-cm-long mirrors, achieving stable vertical travel distances of more than 1.75 m out of a 2- m gap. (407)
Development of Novel Inhibitors Targeting Intracellular Steps of Peptidoglycan Biosynthesis (2007)

The widespread emergence of pathogenic bacterial strains with resistance to antibiotics is becoming a serious threat to public health. Continuous development of novel antibacterials therefore remains one of the biggest challenges to science and unmet needs in the clinics. The biosynthetic pathway of bacterial peptidoglycan, an essential building block of cell walls, has been well studied and appears to be a rich source of attractive enzyme targets for new antibacterials. We have therefore reviewed the intracellular part of peptidoglycan biosynthesis, including the enzymes GlmS, GlmM, GlmU for formation of UDP-GlcNAc, subsequent pentapeptide synthesis by MurA-MurF, and its connection to lipid carrier by MraY and MurG. Naturally occurring inhibitors and the development of low-molecular weight inhibitors of the intracellular part of peptidoglycan synthesis are presented.
XML dataspaces for mobile agent coordination (2000)

Article Free Access Share on XML dataspaces for mobile agent coordination Authors: Giacomo Cabri Dipartimento di Scienze dell'Ingegneria - Università di Modena e Reggio Emilia, Via Campi 213/b - 41100 Modena - ITALY Dipartimento di Scienze dell'Ingegneria - Università di Modena e Reggio Emilia, Via Campi 213/b - 41100 Modena - ITALYView Profile , Letizia Leonardi Dipartimento di Scienze dell'Ingegneria - Università di Modena e Reggio Emilia, Via Campi 213/b - 41100 Modena - ITALY Dipartimento di Scienze dell'Ingegneria - Università di Modena e Reggio Emilia, Via Campi 213/b - 41100 Modena - ITALYView Profile , Franco Zambonelli Dipartimento di Scienze dell'Ingegneria - Università di Modena e Reggio Emilia, Via Campi 213/b - 41100 Modena - ITALY Dipartimento di Scienze dell'Ingegneria - Università di Modena e Reggio Emilia, Via Campi 213/b - 41100 Modena - ITALYView Profile Authors Info & Claims SAC '00: Proceedings of the 2000 ACM symposium on Applied computing - Volume 1March 2000 Pages 181–188https://doi.org/10.1145/335603.335738Published:19 March 2000Publication History 27citation588DownloadsMetricsTotal Citations27Total Downloads588Last 12 Months10Last 6 weeks5 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Effect of dasatinib on the activity of trastuzumab in HER2-overexpressing breast cancer cells (2009)

1084 Background: Breast cancer is the most common neoplasia in women. Although important advances in its treatment have been made along the last years, in the metastatic setting this disease remains incurable. One group of molecules involved in breast cancer genesis/progression are tyrosine kinases. HER-2 is a receptor tyrosine kinase that is overexpressed in a subset of patients with breast cancer. Targeting of HER-2 with trastuzumab a monoclonal antibody that acts on HER-2 has demonstrated clinical benefit. However, as a single agent its antitumoral activity is limited. Methods: Here we have investigated whether the action of trastuzumab, can be potentiated by dasatinib, a small molecule inhibitor that acts on several receptor and non-receptor tyrosine kinases. To this end, we have used cancer cell lines and in vivo xenografted mouse models. MTT proliferation and other apoptosis assays, biochemical and microarray experiments were performed to investigate the molecular bases of the action of the combined trastuzumab plus dasatinib treatment. Results: Combination of trastuzumab and dasatinib was synergic on breast cancer cells overexpressing HER-2, but not on cells with a normal complement of its receptor. In vivo xenograft studies confirmed the antitumoral action of this drug combination. Studies on the mechanism of action showed that this drug combination triggered apoptosis in HER-2 overexpressing cells. Apoptosis was evidenced by increased Annexin V staining, and was found to occur in a caspase-independent manner. In addition, an action of the drug combination on cell cycle could be identified, and the drugs decreased cyclins E1/2, B, and Cdk2, in addition to increasing p27. Microarray as well as biochemical analyses showed that the drug combination provoked a decrease in HER receptor phosphorylation, followed by interruption of downstream signalling. These changes resulted in alterations in the levels of proteins involved in DNA repair. Moreover, treatment with the drug combination caused a DNA damage response as evidenced by increased γH2AX. Conclusions: The effective antitumoral action of the drug combination opens new avenues for the clinical exploration of this drug combination in breast cancer patients overexpressing HER-2. No significant financial relationships to disclose.
Liquid Chromatography-Mass Spectrometric Analysis of Dehydroepiandrosterone and Related Steroids Utilizing a Temperature-Responsive Stationary Phase (2014)

A new method was developed for the analysis of age-related steroids, such as dehydroepiandrosterone (DHEA), androstenedione (ASD), and testosterone (TES), utilizing a temperature-responsive polymer of poly(N-isopropylacrylamide)(PNIPAAm) as the stationary phase of LC-MS. A temperature-dependent separation of the steroids was achieved using an aqueous mobile phase. The efficacy of MeOH as an organic modifier in temperature-responsive chromatography (TRC) was also evaluated by LC-MS analysis of steroids. Although the MeOH content in the mobile phase did not significantly influence the resolution, MeOH enhanced the peak intensities of most of the steroids with an atmospheric pressure chemical ionization (APCI) interface. Well-resolved chromatograms of three steroids in plasma and saliva were obtained at 50 °C with a 5% MeOH aqueous solution as the eluent. To increase the detection sensitivity for MS, DHEA was derivatized with isonicotinoyl azide (INA), and subjected to LC-ESI-MS/MS.
Ligands for histamine H3 receptors modulate cell proliferation and migration in rat oxyntic mucosa (2002)

1. (R)-alpha-methylhistamine, a selective agonist of histamine H(3) receptors, promotes mucus secretion and increases the number and volume of mucus-secreting cells. The hypothesis that the increased number of mucous cells could reside in an alteration of homeostasis in the gastric epithelium was investigated. 2. (R)-alpha-methylhistamine was administered to rats 1 h (10-100 mg kg(-1) by intragastric and by intraperitoneal route) and 24 h (100 mg kg(-1) by intragastric route) prior to killing. The (S)-isomer of alpha-methylhistamine (55.4 mg kg(-1)), 100 times less potent than the (R)-isomer at H(3) receptors, and the H(3)-receptor agonist FUB 407 (9.14-91.35 mg kg(-1)) were intragrastically administered 1 h prior to killing. The H(1)-receptor antagonist mepyramine (30 mg kg(-1)), the H(2)-receptor antagonist famotidine (3 mg kg(-1)), and the H(3)-receptor antagonists ciproxifan (3 mg kg(-1)) and clobenpropit (30 mg kg(-1)) were intragastrically administered 30 min before (R)-alpha-methylhistamine. Gastric tissue was processed for histology and immunohistochemistry. 3. Within 1 h, (R)-alpha-methylhistamine and FUB 407 dose-dependently increased the number of BrdU-positive cells and of apoptotic cells. (S)-alpha-methylhistamine failed to modify proliferation and apoptosis. The increase in proliferation by (R)-alpha-methylhistamine was reversed by ciproxifan and clobenpropit, but not by mepyramine and famotidine. 4. (R)-alpha-methylhistamine accelerated the differentiation towards pit cells and their outward migration 24 h after its administration. These effects were counteracted by ciproxifan. The apoptosis rate was unaffected at 24 h. 5. These findings reveal a primary role of histamine H(3)-receptor ligands in modulating cell proliferation and migration in rat fundic mucosa.
Postnatal changes in the localization of prostaglandin D synthetase from neurons to oligodendrocytes in the rat brain. (1987)

Prostaglandin D synthetase (Urade, Y., Fujimoto, N., and Hayaishi, O. (1985) J. Biol. Chem. 260, 12410-12415) in the brain of 2- and 8-week-old rats was biochemically indistinguishable as judged by Mr (26,000), pI values (4.35-4.75), Km for prostaglandin H2 (approximately 20 microM), and requirement of sulfhydryl compounds. Furthermore, the enzyme was immunologically the same at both ages, as judged by immunotitration, Ouchterlony immunodiffusion, and immunoblotting analyses using a polyclonal and two monoclonal antibodies specific for the enzyme. However, the cellular localization of the enzyme was markedly different between the two ages, as examined by immunoperoxidase staining with the specific antibodies. The immunoreactivity was found in many neurons in 2-week-old rats but was not detected in most neurons in 8-week-old rats except for multipolar neurons in layers I-II of the neocortex and several clusters of dendrites in the pyriform cortex. In the adult rat, the immunoreactivity was mainly localized in oligodendrocytes. By immunoelectron microscopy, the immunoreactive deposits were seen in rough-surfaced endoplasmic reticulum and outer nuclear membrane of the glial cells.
TiO2 modified FeS Nanostructures with Enhanced Electrochemical Performance for Lithium-Ion Batteries (2013)

Anatase TiO2 modified FeS nanowires assembled by numerous nanosheets were synthesized by using a typical hydrothermal method. The carbon-free nanocoated composite electrodes exhibit improved reversible capacity of 510 mAh g(-1) after 100 discharge/charge cycles at 200 mA g(-1), much higher than that of the pristine FeS nanostructures, and long-term cycling stability with little performance degradation even after 500 discharge/charge cycles at current density of 400 mA g(-1). Full batteries fabricated using the FeS@TiO2 nanostructures anode and the LiMn2O4 nanowires cathode with excellent stability, and good rate capacities could also be achieved. The enhanced electrochemical performance of the composite electrodes can be attributed to the improved conductively of the integrated electrodes and the enhanced kinetics of lithium insertion/extraction at the electrode/electrolyte interface because of the incorporation of anatase TiO2 phase.
Surface hydroxylation of styrene–butadiene–styrene block copolymers for biomaterials (1976)

This work pertains to the development of high strength elastomers potentially useful as nonthrombogenic cardiovascular prostheses. Triblock copolymers of the styrene-butadiene-styrene type have been subjected to surface hydroxylation which provide reactive sites at the surface for the subsequent coupling of heparin while retaining the unique mechanical properties of the SBS copolymers. Curves of hydroxyl content versus the copolymer film thickness demonstrate the effect of swelling in the surface region on the product distribution and on the time dependence of the hydroxylation process. In addition, the effect of time, temperature, and the composition of the reaction bath on the diffusion/reaction process is shown. Finally, the general applicability of this surface modification scheme to the development of biomaterials is discussed.
Ultra high data rate CMOS FEs (2011)

The availability of numerous mm-wave frequency bands for wireless communication has motived the exploration of multi-band and multi-mode integrated components and systems in the main stream CMOS technology. This opportunity has faced the RF designer with the transition between schematic and layout. Modeling the performance of circuits after layout and taking into account the parasitic effects resulting from the layout are two issues that are more important and influential at high frequency design. Performaning measurements using on-wafer probing at 60GHz has its own complexities. The very short wave-length of the signals at mm-wave frequencies makes the measurements very sensitiv to the effective length and bending of the interfaces. This paper presents different 60GHz corner blocks, e.g. Low Noise Amplifier, Zero IF mixer, Phase-Locked Loop, A Dual-Mode Mm-Wave Injection-Locked Frequency Divider and an active transformed power amplifiers implemented in CMOS technologies. These results emphasize the feasibility of the realization 60GHZ integrated components and systems in the main stream CMOS technology.
Ion trap studies of association processes in collisions of CH3(+) and CD3(+) with n-H2, p-H2, D2, and He at 80 K (1989)

Formation of stable CH5(+) and CD5(+) has been studied in a liquid nitrogen cooled radio-frequency (RF) ion trap. Ternary rate coefficients, k3, have been measured for He, H2, and D2 as the stabilizing collision partner. The results for He are in satisfying agreement with SIFT data. The experiments have been performed at very low densities permitting information to be extracted on the radiative association process. Because both k3 and the radiative rate coefficient k(r) are observed under the same experimental conditions, comparison leads to a reliable upper limit of the radiative stabilizing rate of the intermediate CH5(+) collision complex. The results are significantly smaller than the values currently discussed in the literature, but they are in accord with infrared relaxation rates measured directly for highly excited CH5(+) ions. Using two different mixtures of p-H2 and o-H2 at 80 K, the influence of the H2 rotational energy was determined. The derived ratio is four times smaller than predicted from theoretical work.
Thermal and Electric Parameter Analysis of DC–DC Module Based on Resonant Switched Capacitor Converter (2022)

This elaboration presents the concept of the design, parameters, experimental investigation, and thermal numerical model solved using the finite element method of a high-power-density DC–DC converter. The analyzed unit can be utilized as a stand-alone converter or as a module for a scalable high-voltage gain system. The converter has a decreased bill of materials since it does not use typical chokes and heatsinks. It is based on switched capacitor circuits supported by a resonant choke which protects against inrush currents. A printed circuit board is utilized not only for the resonant inductance design but also for cooling transistor and diode devices. The paper demonstrates the design concept and the achieved parameters. Experimental results show heat distribution on the printed circuit board and components in a steady state and dynamical states as well. The converter parameters and their efficiency are measured as well. The convergence of experimental results and heating simulations is demonstrated. The numerical model is used for the investigation of design cases. The printed circuit board size, thermal via pattern, and heating process during the overload of the converter are investigated.