gebhart/patrepeval huggingface dataset:
Design of the laser gun bullets based on microcontroller (2017)

Police lab for testing requirements bullet speed, we designed a microcontroller based on the laser gun. The microcontroller as the core for speedometer, with laser detection plate module, thermal Printer module, display and buttons module, USB data interface module, wireless modules and stable voltage module, it can measure the speed of a series of work by Ligation of these modules. First, fired projectiles for testing by the laser detection plate module. Then, Transfer the detected data into the microcontroller. In the microcontroller detection data is processed and then printed out by thermal printer. Via USB data interface for data uploaded to a computer to save. While on the steps required to be operated by the controller.
An evidence-based methodology for systematic evaluation of clinical outcome assessment measures for traumatic brain injury (2020)

The EB-COP provides a systematic methodology for conducting more precise, evidence-based assessment of COAs by evaluating performance within specific COUs. The EB-COP platform was shown to be feasible when applied to a TBI COA frequently used to detect treatment effects and can be modified to address other populations and COUs. Additional testing and validation of the EB-COP are warranted.
The need for fast communication in hardware-based speculative chip multiprocessors (1999)

Chip-multiprocessor (CMP) architectures are a promising design alternative to exploit the ever-increasing number of transistors that can be put on a die. To deliver high performance on applications that cannot be easily parallelized, CMPs can use additional support for speculatively executing the possibly data-dependent threads of an application. While some of the cross-thread dependences in applications must be handled dynamically, others can be fully determined by the compiler. For the latter dependences, the threads can be made to synchronize and communicate either at the register level or at the memory level. In the past, it has been unclear whether the higher hardware cost of register-level communication is cost-effective. In this paper, we show that the wide-issue dynamic processors that will soon populate CMPs, make fast communication a requirement for high performance. Consequently, we propose an effective hardware mechanism to support communication and synchronization of registers between on-chip processors. Our scheme adds enough support to enable register-level communication without specializing the architecture so much toward speculation that it leads to much unutilized hardware under workloads that do not need speculative parallelization. Finally, the scheme allows the system to achieve near ideal performance.
Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitors (2012)

The zinc-dependent mammalian histone deacetylase (HDAC) family comprises 11 enzymes, which have specific and critical functions in development and tissue homeostasis. Mounting evidence points to a link between misregulated HDAC activity and many oncologic and nononcologic diseases. Thus the development of HDAC inhibitors for therapeutic treatment garners a lot of interest from academic researchers and biotechnology entrepreneurs. Numerous studies of HDAC inhibitor specificities and molecular mechanisms of action are ongoing. In one of these studies, mass spectrometry was used to characterize the affinities and selectivities of HDAC inhibitors toward native HDAC multiprotein complexes in cell extracts. Such a novel approach reproduces in vivo molecular interactions more accurately than standard studies using purified proteins or protein domains as targets and could be very useful in the isolation of inhibitors with superior clinical efficacy and decreased toxicity compared to the ones presently tested or approved. HDAC inhibitor induced-transcriptional reprogramming, believed to contribute largely to their therapeutic benefits, is achieved through various and complex mechanisms not fully understood, including histone deacetylation, transcription factor or regulator (including HDAC1) deacetylation followed by chromatin remodeling and positive or negative outcome regarding transcription initiation. Although only a very low percentage of protein-coding genes are affected by the action of HDAC inhibitors, about 40% of noncoding microRNAs are upregulated or downregulated. Moreover, a whole new world of long noncoding RNAs is emerging, revealing a new class of potential targets for HDAC inhibition. HDAC inhibitors might also regulate transcription elongation and have been shown to impinge on alternative splicing.
Posttransplant Allosensitization in Low Immunological Risk Kidney and Kidney-Pancreas Graft Recipients (2014)

Allosensitization against HLA class II ± I after transplant was associated with adverse kidney graft outcomes. A screening protocol seems advisable within the first year in low immunological risk patients.
On the Repudiability of Device Identification and Image Integrity Verification Using Sensor Pattern Noise (2012)

Abstract. In this work we study the power of the methods for digital device identification and image integrity verification, which rely on sensor pattern noise as device signatures, and the repudiability of the conclusions drawn from the information produced by this type of methods. We prove that the sensor pat-tern noise existing in the original images can be destroyed so as to confuse the investigators. We also prove that sensor pattern noise of device A can be easily embedded in the images produced by another device B so that the device identi-fier would mistakenly suggest that the images were produced by device A, rather than by B, and mislead forensic investigations.
Establishment of Imaging Spectroscopy of Nuclear Gamma-Rays based on Geometrical Optics (2017)

Since the discovery of nuclear gamma-rays, its imaging has been limited to pseudo imaging, such as Compton Camera (CC) and coded mask. Pseudo imaging does not keep physical information (intensity, or brightness in Optics) along a ray, and thus is capable of no more than qualitative imaging of bright objects. To attain quantitative imaging, cameras that realize geometrical optics is essential, which would be, for nuclear MeV gammas, only possible via complete reconstruction of the Compton process. Recently we have revealed that "Electron Tracking Compton Camera" (ETCC) provides a well-defined Point Spread Function (PSF). The information of an incoming gamma is kept along a ray with the PSF and that is equivalent to geometrical optics. Here we present an imaging-spectroscopic measurement with the ETCC. Our results highlight the intrinsic difficulty with CCs in performing accurate imaging, and show that the ETCC surmounts this problem. The imaging capability also helps the ETCC suppress the noise level dramatically by ~3 orders of magnitude without a shielding structure. Furthermore, full reconstruction of Compton process with the ETCC provides spectra free of Compton edges. These results mark the first proper imaging of nuclear gammas based on the genuine geometrical optics.
Dose-finding study of intravesical lidocaine in healthy volunteers (2000)

European Society of Anaesthesiologists; 8th Annual Meeting with the Austrian International Congress; Vienna, Austria, 1-4 April 2000
A phase 1 study of everolimus and sorafenib for metastatic clear cell renal cell carcinoma (2011)

The combination of everolimus and sorafenib was associated with acceptable toxicity and evidence of antitumor activity in previously untreated patients with metastatic renal cell carcinoma.
Endovascular Perfusion Augmentation for Critical Care Decreases Vasopressor Requirements while Maintaining Renal Perfusion (2022)

Compared with SCC, EPACC-High and EPACC-Low had decreased norepinephrine requirements with decreased frequency of proximal hypotension. EPACC-Low paradoxically had increased renal perfusion despite having a mechanical resistor in the aorta proximal to the renal arteries. This is the first description of low volume mechanical hemodynamic support in the setting of profound shock from ischemia-reperfusion injury in swine demonstrating stabilized proximal hemodynamics and augmented distal perfusion.
NERVOUS SYSTEM IN POMPEʼS DISEASE (1971)

Journal Article Nervous System in Pompe's Disease: Ultrastructure and Biochemistry Get access P. Gambetti, M.D., P. Gambetti, M.D. Philadelphia, Pa. Search for other works by this author on: Oxford Academic PubMed Google Scholar S. Dimauro, M.D., S. Dimauro, M.D. Philadelphia, Pa. ‡Post-doctoral Fellow of MDAA Search for other works by this author on: Oxford Academic PubMed Google Scholar L. Baker, M.D. L. Baker, M.D. Philadelphia, Pa. Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Neuropathology & Experimental Neurology, Volume 30, Issue 3, July 1971, Pages 412–430, https://doi.org/10.1097/00005072-197107000-00008 Published: 01 July 1971
Induction of terminal differentiation-resistant epidermal cells in mouse skin and in papillomas by different initiators during two-stage carcinogenesis. (1989)

Carcinogen treatment of normal mouse epidermal cells causes some cells, if cultured under the appropriate conditions, to continue to proliferate instead of terminally differentiate, forming foci at 37 degrees C in medium with a calcium level above 0.1 mM. We have examined these Calcium (Ca)-resistant cells formed in the skin of SENCAR mice after treatment with the carcinogen initiator 7,12-dimethylbenz[a]anthracene (DMBA) followed by tumor promotion with 12-O-tetradecanoylphorbol-13-acetate (TPA). Although in our previous studies TPA promotion initially increased the size but reduced the number of foci caused by the carcinogen initiator N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), TPA promotion of DMBA-treated mice increased the size but had no effect on the number of foci. Papillomas resulting from DMBA plus TPA treatment contained many rapidly growing Ca-resistant cells, corroborating our earlier results with MNNG. Permanent cell lines prepared from papilloma-derived foci formed squamous cell carcinomas in nude mice after relatively short periods in culture. These data provide further evidence that Ca-resistant cells may be papilloma (and perhaps carcinoma) precursors in vivo. In addition, since TPA tends to reduce the number of early Ca-resistant cells caused by MNNG but not by DMBA, this may at least partially explain why treatment with DMBA plus TPA is much more effective in producing papillomas in SENCAR mice than is treatment with MNNG plus TPA.
An average model of solid state transformer for dynamic system simulation (2009)

The solid state transformer (SST) is one of the key elements proposed in the National Science Foundation (NSF) Generation-III Engineering Research Center (ERC) ldquoFuture Renewable Electric Energy Delivery and Managementrdquo (FREEDM) Systems Center established in 2008. The SST is used to enable active management of distributed renewable energy resources, energy storage devices and loads. In this paper, a 20 kVA solid state transformer based on 6.5 kV IGBT is proposed for interface with 12 kV distribution system voltage. The average model and control scheme of SST including AC/DC rectifier, dual active bridge (DAB) converter and DC/AC inverter are developed to enable dynamic system level simulation. The developed average model is verified by comparing with the detailed switching model simulation. The dynamic system level SST simulation verifies the proposed controller and the corresponding average model illustrates the functionalities and advantages of the SST in FREEDM system.
Effects of Bile Salt Infusion on Chlorpromazine-lnduced Cholestasis in the Isolated Perfused Rat Liver (1992)

The present study has demonstrated that tauroursodeoxycholate (TUDC), but not taurocholate, can reverse chlorpromazine (CPZ)-induced cholestasis in the isolated perfused rat liver. At an infusion rate of 1.5 mumol/min, TUDC led to restoration of bile flow in the perfused rat liver made cholestatic by the addition of 250 microM CPZ. This reversal was accompanied by an increased excretion of CPZ and its metabolites. A higher infusion rate of 5.0 mumols TUDC/min, however, led to only a transient increase in bile flow and to no increase in CPZ excretion. In contrast to the effects of TUDC, infusion of taurocholate led to an exacerbation of CPZ-induced cholestasis. The differences in the efficacy of the two bile salts may be due to their relative detergent (hydrophobic) properties.
Development of a CMOS-compatible electrostatically actuated diaphragm chamber for micropump application (2008)

This paper presents the development of a diaphragm chamber actuated electrostatically utilizing CMOS-compatible silicon micromachining fabrication process. The process consists of six photolithography steps and five chemical vapor depositions. Etching of the sacrificial oxide layer for the diaphragm chamber is achieved using etch-release holes perforated on the diaphragm, similar to via holes used in IC-fabrication method. From the analysis, the best encapsulation has been successfully demonstrated by growing LPCVD silicon nitride of thickness 0.9¿m. Accomplishing this feat enables electrostatically actuated diaphragm chamber to be developed and in particular, will spur advancement in the development of a CMOS-compatible electrostatically actuated diaphragm micropump.
A Survey of 3DTV Displays: Techniques and Technologies (2007)

The display is the last component in a chain of activity from image acquisition, compression, coding transmission and reproduction of 3-D images through to the display itself. There are various schemes for 3-D display taxonomy; the basic categories adopted for this paper are: holography where the image is produced by wavefront reconstruction, volumetric where the image is produced within a volume of space and multiple image displays where two or more images are seen across the viewing field. In an ideal world a stereoscopic display would produce images in real time that exhibit all the characteristics of the original scene. This would require the wavefront to be reproduced accurately, but currently this can only be achieved using holographic techniques. Volumetric displays provide both vertical and horizontal parallax so that several viewers can see 3-D images that exhibit no accommodation/convergence rivalry. Multiple image displays fall within three fundamental types: holoform in which a large number of views give smooth motion parallax and hence a hologram-like appearance, multiview where a series of discrete views are presented across viewing field and binocular where only two views are presented in regions that may occupy fixed positions or follow viewers' eye positions by employing head tracking. Holography enables 3-D scenes to be encoded into an interference pattern, however, this places constraints on the display resolution necessary to reconstruct a scene. Although holography may ultimately offer the solution for 3DTV, the problem of capturing naturally lit scenes will first have to be solved and holography is unlikely to provide a short-term solution due to limitations in current enabling technologies. Liquid crystal, digital micromirror, optically addressed liquid crystal and acoustooptic spatial light modulators (SLMs) have been employed as suitable spatial light modulation devices in holography. Liquid crystal SLMs are generally favored owing to the commercial availability of high fill factor, high resolution addressable devices. Volumetric displays provide both vertical and horizontal parallax and several viewers are able to see a 3-D image that exhibits no accommodation/convergence rivalry. However, the principal disadvantages of these displays are: the images are generally transparent, the hardware tends to be complex and non-Lambertian intensity distribution cannot be displayed. Multiple image displays take many forms and it is likely that one or more of these will provide the solution(s) for the first generation of 3DTV displays.
Injectable autologous platelet-rich plasma for regenerative medicine in donkeys v1 (2018)

A step-by-step procedure for autologous platelet-rich plasma production was developed for topical percutaneous injection in donkeys. This protocol was used in the following publication: Faillace V, Tambella AM, Fratini M, Paggi E, Dini F, Laus F. Use of autologous platelet-rich plasma for a delayed consolidation of a tibial fracture in a young donkey. The Journal of Veterinary Medical Science, 79(3), 2017: 618-622. (ISSN: 0916-7250) (DOI: 10.1292/jvms.16-0400) https://doi.org/10.1292/jvms.16-0400 https://www.jstage.jst.go.jp/article/jvms/79/3/79_16-0400/_pdf/-char/en
Identification and characterization of 2-keto-3-deoxygluconate kinase and 2-keto-3-deoxygalactonate kinase in the haloarchaeonHaloferax volcanii (2014)

The halophilic archaeon Haloferax volcanii has been proposed to degrade glucose via the semi-phosphorylative Entner-Doudoroff pathway, involving 2-keto-3-deoxygluconate kinase (KDGK) as key enzyme. So far, neither the enzyme has been characterized nor the encoding gene has been identified. In the genome of H. volcanii, two genes, HVO_0549 (kdgK1) and HVO_A0328 (kdgK2), are annotated encoding putative KDGK-1 and KDGK-2. To identify the physiological role of both kinases, transcriptional regulation analyses of both genes and growth experiments of the respective deletion mutants were performed on different sugars. Further, recombinant KDGK-1 and KDGK-2 were characterized. Together, the data indicate that KDGK-1 represents the functional constitutively expressed KDG kinase in glucose degradation, whereas KDGK-2 is an inducible 2-keto-3-deoxygalactonate kinase likely involved in d-galactose catabolism.
Subtypes of Hepatitis B Surface Antigen in Native‐Born and Immigrant Israelis (1976)

A survey of HBsAg among Jerusalem blood donors revealed a prevalence of 0.89% and a predominance of subtype ay (85%) compared with ad (15%). A simultaneous survey of patients with HBsAg-positive viral hepatitis revealed a similar predominance of ay (85%) compared with ad (15%). The uniform distribution of the dominant ay subtype among both carriers and patients, representing a diversity of ethnic and national origins, supports the premise that ad and ay subtypes are preferentially correlated with regional epidermiologic, rather than host or disease-related factors.
Nitric oxide increases the spontaneous firing rate of rat medial vestibular nucleus neurons in vitro via a cyclic GMP‐mediated PKG‐independent mechanism (2004)

The effects of nitric oxide (NO) on the discharge rate of medial vestibular nucleus neurons (MVNn) were investigated in rat brainstem slices. The NO-donor sodium nitroprusside (SNP, 200 microM) caused a marked enhancement (+36.7%) of MVNn spontaneous firing rate, which was prevented by the NO-scavenger, carboxy-PTIO (300 microM). The SNP effects were not modified (+37.4%) by synaptic uncoupling, suggesting that NO influences intrinsic membrane properties of MVNn rather than the synaptic input they receive. The excitatory action of SNP was virtually abolished by slice pretreatment with the soluble guanylyl cyclase inhibitor, ODQ (10 microM), and it was mimicked (+33.1%) by the cGMP analogue 8-Br-cGMP (400 microM). Protein kinase G (PKG) and cAMP/protein kinase A (PKA) were both excluded as downstream effectors of the NO/cGMP-induced excitation. However, the cyclic nucleotide-gated (CNG) channel blockers, L-cis-diltiazem (LCD, 100 microM) and Sp-8-Br-PET-cGMPS (100 microM), significantly reduced the firing rate increase produced by 8-Br-cGMP. Moreover, LCD alone decreased spontaneous MVNn firing (-19.7%), suggesting that putative CNG channels may contribute to the tonic control of resting MVNn discharge. 8-Br-cAMP (1 mM) also elicited excitatory effects in MVNn (+40.8%), which occluded those induced by 8-Br-cGMP, indicating that the two nucleotides share a common target. Finally, nested-polymerase chain reaction assay revealed the expression of CNG channel alpha subunit transcript in MVNn. Our data provide the first demonstration that NO/cGMP signalling modulates MVNn spontaneous firing through a mechanism that is independent of PKG or PKA and probably involves activation of CNG channels.
Lieb-Robinson Bound and Locality for General Markovian Quantum Dynamics (2010)

The Lieb-Robinson bound shows the existence of a maximum speed of signal propagation in discrete quantum mechanical systems with local interactions. This generalizes the concept of relativistic causality beyond field theory, and provides a powerful tool in theoretical condensed matter physics and quantum information science. Here, we extend the scope of this seminal result by considering general markovian quantum evolution, where we prove that an equivalent bound holds. In addition, we use the generalized bound to demonstrate that correlations in the stationary state of a Markov process decay on a length scale set by the Lieb-Robinson velocity and the system's relaxation time.
Coexpression of ecto-5′-nucleotidase/CD73 with specific NTPDases differentially regulates adenosine formation in the rat liver (2011)

Ectonucleotidases modulate purinergic signaling by hydrolyzing ATP to adenosine. Here we characterized the impact of the cellular distribution of hepatic ectonucleotidases, namely nucleoside triphosphate diphosphohydrolase (NTPDase)1/CD39, NTPDase2/CD39L1, NTPDase8, and ecto-5'-nucleotidase/CD73, and of their specific biochemical properties, on the levels of P1 and P2 receptor agonists, with an emphasis on adenosine-producing CD73. Immunostaining and enzyme histochemistry showed that the distribution of CD73 (protein and AMPase activity) overlaps partially with those of NTPDase1, -2, and -8 (protein levels and ATPase and ADPase activities) in normal rat liver. CD73 is expressed in fibroblastic cells located underneath vascular endothelial cells and smooth muscle cells, which both express NTPDase1, in portal spaces in a distinct fibroblast population next to NTPDase2-positive portal fibroblasts, and in bile canaliculi, together with NTPDase8. In fibrotic rat livers, CD73 protein expression and activity are redistributed but still overlap with the NTPDases mentioned. The ability of the observed combinations of ectonucleotidases to generate adenosine over time was evaluated by reverse-phase HPLC with the recombinant rat enzymes at high "inflammatory" (500 μM) and low "physiological" (1 μM) ATP concentrations. Overall, ATP was rapidly converted to adenosine by the NTPDase1+CD73 combination, but not by the NTPDase2+CD73 combination. In the presence of NTPDase8 and CD73, ATP was sequentially dephosphorylated to the CD73 inhibitor ADP, and then to AMP, thus resulting in a delayed formation of adenosine. In conclusion, the specific cellular cocompartmentalization of CD73 with hepatic NTPDases is not redundant and may lead to the differential activation of P1 and P2 receptors, under normal and fibrotic conditions.