gebhart/patrepeval huggingface dataset:
P2540Sex-specific differences in the clinical presentation, surgical complications, and course of chronic thromboembolic pulmonary hypertension (2019)

Abstract Background Women are more susceptible to develop several forms of pulmonary hypertension, but they may have better survival rates than men. Sparse data are available concerning sex-specific differences in chronic thromboembolic pulmonary hypertension (CTEPH). Purpose and methods We investigated sex-specific differences in the clinical presentation of CTEPH, functional parameters, exposure to pulmonary endarterectomy (PEA), and survival. Results Women constituted half of the study population (N=679 treatment-naïve patients from the European CTEPH registry) and were characterized by a lower prevalence of some cardiovascular risk factors (e.g. prior acute coronary syndrome, smoking habit, chronic obstructive pulmonary disease), but more prevalent obesity, cancer, and thyroid diseases. Median age was 62 (IQR 50–73) years in women and 63 (IQR 53–70) in men. Women underwent PEA less often than men (54% vs 65%; Figure 1, Panel A) and were exposed to fewer additional cardiac procedures, notably coronary artery bypass graft surgery (0.5% vs. 9.5%). The prevalence of specific reasons for not being operated, including the patient's refusal and the proportion of proximal vs. distal lesions, did not differ between sexes. A total of 57 (17.0%) deaths in women and 70 (20.7%) in men were recorded over long-term follow-up. Female sex was positively associated with long-term survival (adjusted Hazard Ratio 0.66; 95% Confidence Interval 0.46–0.94). Short-term mortality was identical in the two groups (Figure 1, Panel B). Conclusions Women with CTEPH had a lower prevalence of cardiovascular risk factors and underwent PEA less frequently than men, who, in turn, were more often exposed to additional major cardiac surgery procedures. Women had more favorable long-term survival. Acknowledgement/Funding The CTEPH registry is supported by a research grant from Actelion Pharmaceuticals Ltd.
The role of race, socioeconomic status, and distance traveled on the outcome of African-American patients with multiple myeloma. (2006)

The incidence and mortality of multiple myeloma (MM) in African-Americans is double that in whites. We questioned whether race, socioeconomic status, and distance traveled affect overall survival. In a retrospective review of the records of 292 patients with MM. We found that the median age was 60 years and 38 patients were African-Americans. The mean distance traveled was 67.7 miles. The median overall survival was similar in African-Americans and whites. Race, distance traveled and socioeconomic status were not independent prognostic factors for overall survival. In conclusion, socioeconomic status, distance traveled and race did not affect outcomes of MM patients treated at a specialized myeloma center.
ChemInform Abstract: 1,1‐DIPHENYL‐ALKENE 2. MITT. ALKYLIERUNG VON 1,1‐DIPHENYL‐PROPEN‐CARBANIONEN, DAS PRINZIP DER ′GERINGSTEN VERAENDERUNG′ (1972)

Abstract Die Olefine (I) bilden mit Na in flüssigem Ammoniak Carbanionen (II), die mit den Alkylhalogeniden (III) alkyliert werden.
[Effect of stromal cell-derived factor-1 and its receptor CXCR4 on liver metastasis of human colon cancer]. (2009)

SDF-1/CXCR4 biological axis play an important role in liver metastasis of human colon cancer. Arrest of CXCR4 can inhibit liver metastasis of colon cancer through blocking cell proliferation and migration induced by SDF-1.
Determination of heterocyclic amines in flame‐grilled fish patty by capillary electrophoresis (1996)

A simple and reliable capillary zone electrophoretic (CZE) method for quantifying mutagenic and carcinogenic heterocyclic amines (HCAs) in cooked foods with UV-visible diode-array detection is described. The buffer system consisted of 50 mM disodium hydrogen phosphate, 30 mM sodium chloride, 20 mM citric acid and 26% methanol at pH 2.1. An uncoated silica tubing, 51 cm in length, was used for the CZE separation. The capillary tubing temperature was maintained at 25 degrees C with a constant voltage of 20 kV. The reproducibility of the method was over 95% for a five-replicate analysis of 10 micrograms/l-spiked 2-amino-3,4,7,8-tetramethylimidazo[4,5-f]quinoxaline (4,7,8-TriMeIQx) and the detection limit was in the low microgram/l range with coefficients of variation between 6 and 18%. An analytical run took only 15 min for 12 known HCAs. Using this procedure, up to 30 samples could be analysed in a single day. The method is reliable and can be used for screening of various HCAs. It has been applied to assess the concentrations of heterocyclic amines in otak-otak, a Malay-style grilled fish patty. The major mutagenic contaminant found in this foodstuff was 2-aminodipyrido[1,2-a:3',2'-d]imidazole (Glu-P-2) (286-1068 micrograms/kg), followed by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) (1.6-13.0 micrograms/kg) and 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) (14.0-87.5 micrograms/kg). Two co-mutagens norharman (NH) and harman (H) were also detected in otak-otak at levels of 2.0-13.0 micrograms/kg and 12.8-21.3 micrograms/kg, respectively. The substantial amount of Glu-P-2 detected in otak-otak is probably a result of the ingredients used and the high temperature grilling process.
Supplementary Tables 1-3, Figure 1 from Genetic Determinants for Promoter Hypermethylation in the Lungs of Smokers: A Candidate Gene-Based Study (2023)

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Poloxamer 407 as a Thermogelling and Adhesive Polymer for Rectal Administration of Short-Chain Fatty Acids (2001)

The 18% poloxamer 407 concentration provided a solution that was liquid at room temperature, that gelled at 37 degrees C, possessed adhesive properties, and controlled short-chain fatty acid release.
Inclusion of non-ideal effects in 3-D PIC simulations of ion diodes (2002)

Summary form only given. The 3-D particle-in-cell code QUICKSILVER has been used extensively to simulate ion diodes. These simulations use an idealized setup; perfectly azimuthally-symmetric geometric and applied magnetic field, electrons incident on the anode are simply removed from the system, and the entire anode emission region emits only a single ion species directly from the physical surface throughout the simulation. Results from SABRE experiments exhibit significant differences with such "ideal" simulations. First, the beam has a time-dependent composition; early in time it is mostly the desired Li/sup +/ ions, but these are rapidly replaced by protons and C/sup +n/ (the "parasitic load"). Second, the diode impedance drops rapidly after peak lithium beam power. Third, there are substantial current losses in the diode (i.e. current not carried by the ion beam).
Polyvinylpyridine, a Versatile Solid Phase for Coordinative Immobilisation of Palladium Precatalysts - Applications in Suzuki-Miyaura Reactions (2006)

The immobilisation of an oxime-based palladacycle on polyvinylpyridine (PVP) resin affords a reusable, air, moisture and thermally stable palladium precatalyst which exerts high activity in Suzuki-Miyaura reactions both in batch as well as continuous-flow processes. Evidence is presented which shows that, besides serving as an anchor for the precatalyst, PVP also acts as a scavenger for Pd particles present in solution.
Magnetic circular dichroism of cyclic .pi.-electron systems. 27. Mesoionic compounds (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMagnetic circular dichroism of cyclic .pi.-electron systems. 27. Mesoionic compoundsAndreas Bottcher, Gerhard Raabe, and Josef MichlCite this: J. Org. Chem. 1985, 50, 25, 5050–5055Publication Date (Print):December 1, 1985Publication History Published online1 May 2002Published inissue 1 December 1985https://pubs.acs.org/doi/10.1021/jo00225a010https://doi.org/10.1021/jo00225a010research-articleACS PublicationsRequest reuse permissionsArticle Views96Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Disruption of primary imprinting during oocyte growth leads to the modified expression of imprinted genes during embryogenesis (1998)

Parthenogenetic embryos, which contained one genome from a neonate-derived non-growing oocyte and the other from a fully grown oocyte, developed to day 13.5 of gestation in mice, 3 days longer than previously recorded for parthenogenetic development. To investigate the hypothesis that disruption of primary imprinting during oocyte growth leads to the modified expression of imprinted genes and this parthenogenetic phenotype, we have examined Peg1/Mest, Igf2, Peg3, Snrpn, H19, Igf2r and excess p57KIP2. We show that paternally expressed genes, Peg1/Mest, Peg3 and Snrpn, are expressed in the parthenotes, presumably due to a lack of maternal epigenetic modifications during oocyte growth. In contrast, the expression of Igf2, which is repressed in a competitive manner by transcription of the H19 gene, was very low. Furthermore, we show that the maternally expressed Igf2r and p57KIP2 genes were repressed in the alleles of the non-growing oocyte indicating maternal modifications during oocyte growth are necessary for its expression. Thus, our results show that primary imprinting during oocyte growth exhibits a crucial effect on both the expression and repression of maternal alleles during embryogenesis.
Construction of Inorganic-Rich Cathode Electrolyte Interphase on Co-Free Cathodes (2023)

Lithium-rich layered oxides (LRLOs), with the chemical formula of <i>x</i>Li<sub>2</sub>MnO<sub>3</sub>·(1 - <i>x</i>)LiMO<sub>2</sub>, delivering higher specific discharge capacity, are potential cathode materials for lithium-ion batteries. However, the dissolution of transition metal ions and the instability of the cathode-electrolyte interphase (CEI) hinder the commercial application of LRLOs. Herein, a simple and affordable method is developed for the construction of a robust CEI layer by quenching a kind of cobalt-free LRLO, Li<sub>1.2</sub>Ni<sub>0.15</sub>Fe<sub>0.1</sub>Mn<sub>0.55</sub>O<sub>2</sub> (denoted as NFM), in 1,1,2,2-tetrafluoroethyl-2,2,2-trifluoroethyl ether solvent. This robust CEI, with well-distributed LiF, TMF<sub><i>x</i></sub>, and partial organic component CF<sub><i>x</i></sub>, performs as a physical barrier to prevent NFM from direct contact with the electrolyte, suppresses the oxygen release, and ensures the CEI layer stability. The customized CEI with LiF and TMF<sub><i>x</i></sub>-rich phase considerably enhances the NFM cycle stability and the initial coulomb efficiency and inhibits voltage fading. This work provides a valuable strategy for designing stable interface chemistry on the cathode of lithium-ion batteries.
Cascaded multiple classifiers for secondary structure prediction (2000)

We describe a new classifier for protein secondary structure prediction that is formed by cascading together different types of classifiers using neural networks and linear discrimination. The new classifier achieves an accuracy of 76.7% (assessed by a rigorous full Jack-knife procedure) on a new nonredundant dataset of 496 nonhomologous sequences (obtained from G.J. Barton and J.A. Cuff). This database was especially designed to train and test protein secondary structure prediction methods, and it uses a more stringent definition of homologous sequence than in previous studies. We show that it is possible to design classifiers that can highly discriminate the three classes (H, E, C) with an accuracy of up to 78% for beta-strands, using only a local window and resampling techniques. This indicates that the importance of long-range interactions for the prediction of beta-strands has been probably previously overestimated.
What Lies behind the Ischemic Stroke: Aortic Dissection? (2014)

Introduction. Some cases with aortic dissection (AD) could present with various complaints other than pain, especially neurological and cardiovascular manifestations. AD involving the carotid arteries could be associated with many clinical presentations, ranging from stroke to nonspecific headache. Case Report. A 71-year-old woman was admitted to emergency department with vertigo which started within the previous one hour and progressed with deterioration of consciousness following speech disorder. On arrival, she was disoriented and uncooperative. Diffusion magnetic resonance imaging (MRI) of brain was consistent with acute ischemia in the cerebral hemisphere. Fibrinolytic treatment has been planned since symptoms started within two hours. Echocardiography has shown the dilatation of ascending aorta with a suspicion of flap. Computed tomography (CT) angiography has been applied and intimal flap has been detected which was consistent with aortic dissection, intramural hematoma of which was reaching from aortic arch to bilateral common carotid artery. Thereafter, treatment strategy has completely changed and surgical invention has been done. Conclusion. In patients who are admitted to the emergency department with the loss of consciousness and stroke, inadequacy of anamnesis and carotid artery involvement of aortic dissection should be kept in mind.
Object recognition and incremental learning algorithms for a web-based telerobotic system (2003)

This paper describes a web-based telerobotic system with two basic capabilities: object recognition and incremental or continual learning. Within this context, the present paper investigates the feasibility of applying several distance-based classifiers to remote object recognition tasks. On the other hand, incremental learning enables the system to maintain a representative set of past training examples that are used together with new data to appropriately modify the currently held knowledge. This can constitute a very significant advantage because it allows a system to continually increase its knowledge and accordingly, to enhance its performance in recognition as it learns. And also, because this capability allows to detect an incorrect or anomalous employment of this particular remote system. The performance of the system is evaluated by means of an empirical analysis addressed to assess two competing goals: computing time and recognition accuracy.
Multi-Rate Acquisition for Dead Time Reduction in Magnetic Resonance Receivers: Application to Imaging With Zero Echo Time (2017)

For magnetic resonance imaging of tissues with very short transverse relaxation times, radio-frequency excitation must be immediately followed by data acquisition with fast spatial encoding. In zero-echo-time (ZTE) imaging, excitation is performed while the readout gradient is already on, causing data loss due to an initial dead time. One major dead time contribution is the settling time of the filters involved in signal down-conversion. In this paper, a multi-rate acquisition scheme is proposed to minimize dead time due to filtering. Short filters and high output bandwidth are used initially to minimize settling time. With increasing time since the signal onset, longer filters with better frequency selectivity enable stronger signal decimation. In this way, significant dead time reduction is accomplished at only a slight increase in the overall amount of output data. Multi-rate acquisition was implemented with a two-stage filter cascade in a digital receiver based on a field-programmable gate array. In ZTE imaging in a phantom and in vivo, dead time reduction by multi-rate acquisition is shown to improve image quality and expand the feasible bandwidth while increasing the amount of data collected by only a few percent.
Survey on forced oscillations in power system (2017)

The oscillations in a power system can be categorized into free oscillations and forced oscillations. Many algorithms have been developed to estimate the modes of free oscillations in a power system. Recently, forced oscillations have caught many researchers’ attentions. Techniques are proposed to detect forced oscillations and locate their sources. In addition, forced oscillations may have a negative impact on the estimation of mode and mode-shape if they are not properly accounted for. To improve the power system reliability and dynamic properties, it is important to first distinguish forced oscillations from free oscillations and then locate the sources of forced oscillations in a timely manner. The negative impact of forced oscillation can be mitigated when they are detected and located. This paper provides an overview of the analysis technique of forced oscillations in power systems. In addition, some future opportunities are discussed in forced oscillation studies.
Abstract 1340: High densities of tumor-infiltrating FOXP3+ regulatory T cells in primary tumor or lymph node metastasis are associated with favorable outcome in gastric cancer (2010)

Abstract Background: It has been reported that the frequency of FOXP3+ regulatory T cells (Tregs) among tumor-infiltrating lymphocytes is increased in cancer-bearing patients. We designed the study to determine the prognostic significance of FOXP3+ Tregs in gastric cancer. Methods: Tissue microarray and immunohistochemistry were used to assess the densities of FOXP3+ T regs in primary tumor tissue (n=216) and unmatched metastatic tumor tissue of regional lymph nodes (n=149) from gastric cancer patients. Numbers of FOXP3+ Tregs were counted using an image analysis program. FOXP3+ Treg densities were evaluated for correlation with clinicopathologic characteristics and overall survival. Results: With respect to primary tumor, low density of FOXP3+ Tregs was associated with advanced T stage (p = 0.028), but not with any other clinicopathologic features. Kaplan-Meier survival analysis revealed that the high density group of FOXP3+ Tregs had longer survival time than the low density group (p = 0.001, log-rank test). In multivariate analysis, FOXP3+ Treg density remained an independent prognostic factor with hazard ratio (95% CI) of 0.651 (0.435-0.975). In addition, it was found that FOXP3+ Treg density in metastatic tumor of lymph nodes was an independent prognostic indicator, i.e., high density of FOXP3+ Tregs was significantly associated with improved survival (hazard ratio (95% CI) = 0.519 (0.318-0.848)). Conclusions: FOXP3+ Treg densities in not only primary tumor, but also metastatic loci of regional lymph nodes were significantly associated with patient survival in gastric cancer. As our finding that high density of FOXP3+ Tregs was related to favorable prognosis contrasts with several previous studies, further investigation will be needed. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1340.
Food additives in chemistry lessons (2012)

Els additius alimentaris son components comuns en els aliments i un bon context d'estudi per a les classes de quimica. En aquest treball, es descriu una sessio de laboratori per a estudiants de secundaria (17-18 anys). Els alumnes van determinar algunes propietats fisiques i quimiques de quatre additius «desconeguts». Utilitzant els resultats de les proves, els estudiants havien d'esbrinar, entre els deu possibles additius d'una determinada llista, quins eren els quatre additius
analitzats. Els estudiants van treballar en petits grups. Un 26 % dels estudiants (grups) va identificar correctament els quatre additius, un 29 % en va identificar tres i el 45 % en va identificar dos.
Graph-Based Remerging of Genealogical Databases (2001)

Computers have helped family history research tremendously, and personal genealogyprograms help people organize their information in a way not previously possible. However,most personal genealogy software packages available today suffer from weak mergingfunctionality, which makes collaboration with others much more difficult than it needs to be. Inparticular, if someone shares a copy of their electronic genealogical database with a relative, andthen both make additions and/or changes to the data, there is currently no reasonable way in mostgenealogical programs to merge these changes together. This paper reviews current approachesto this problem and presents an algorithm for taking much of the agony out of the mergingprocess by taking into account the relationships of individuals in the database.
Capillary Electrochromatography−Mass Spectrometry of Zwitterionic Surfactants (2005)

This work describes the on-line hyphenation of a packed capillary electrochromatography (CEC) column with an internally tapered tip coupled to electrospray ionization-mass spectrometry (ESI-MS) and atmospheric pressure chemical ionization-mass spectrometry (APCI-MS) for the analysis of betaine-type amphoteric or zwitterionic surfactants (Zwittergent). A systematic investigation of the CEC separation and MS detection parameters comparing ESI and APCI is shown. First, a detailed and optimized manufacturing procedure for fabrication of the CEC-MS column with a reproducible internally tapered tip (7-9 microm) is presented. Next, the optimization of the separation parameters by varying the C(18) stationary-phase particle size (3 versus 1.5 microm), as well as mobile-phase composition including acetonitrile (ACN) volume fraction, ionic strength, and pH is described. The optimized separation is achieved using 3-microm C(18) packing with 75% ACN (v/v), 5 mM Tris at pH 8.0. Optimization for on-line CEC-ESI-MS detection is then done varying both the sheath liquid and spray chamber parameters while evaluating the use of random versus structured factorial table experimental designs. The more structured approach allows fundamental analysis of individual ESI-MS parameters while minimizing CEC and MS equilibration time between settings. A comparison of CEC-ESI-MS to CEC-APCI-MS using similar sheath and spray chamber conditions presents new insight for coupling of CEC to APCI-MS. The sheath liquid flow rate required to maintain adequate sensitivity is much higher in APCI source (50 microL/min) as compared to the ESI source (3 microL/min). The on-line mass spectra obtained in the full scan mode show that fragmentation in the two sources occurs at different positions on the Zwittergent molecules. For ESI-MS, the protonated molecular ion is always highest in abundance with minor fragmentation occurring due to the loss of the alkyl chain. In contrast, the APCI-MS spectra show that the highest abundant ion resulted by elimination of propane sulfonate from the Zwittergent molecule. A comparison of the sensitivity between the two sources in positive ionization SIM mode shows that CEC-ESI-MS provides an impressive limit of detection (LOD) of 5 ng/mL, which is at least 3 orders of magnitude lower than CEC-APCI-MS (LOD 100 microg/mL). Finally, the optimized CEC-MS methods comparing ESI and APCI are applied for separation and structural characterization of a real industrial zwittergent sample, Rewoteric AM CAS.