gebhart/patrepeval huggingface dataset:
Structure of the Human Urokinase Receptor Gene and Its Similarity to CD59 and the Ly‐6 Family (1995)

Urokinase plasminogen activator receptor (uPAR) gene expression has been implicated in many important biological processes including cell invasiveness and migration. The uPAR gene was cloned from a human genomic library by hybridization with a uPAR cDNA. The complete structure of the human uPAR gene, including a 21.23-kb transcription unit with 204 bp 5' and 239 bp 3' flanking sequences, was determined by comparison with the uPAR cDNA sequence. The uPAR gene is composed of seven exons and six introns. The seven exons of 101, 111, 144, 162, 135, 147 and 563 bp are separated by six introns of approximately 2.04, 2.62, 8.42, 0.906, 3.10 and 2.78 kb. Exons 1-7 encode 19, 37, 48, 54, 45, 49 and 83 amino acid residues, respectively. A CpG-rich island and sequences related to the transcription factors AP-1, AP-2, c-Jun and NF kappa B are present, but no potential TATA or CAAT boxes were found in the proximal 5' region of the uPAR gene. Comparison of the exon organization of the uPAR gene with that of human CD59 and murine Ly-6 reveals similarity to all three domains encoded by the uPAR exons (2 + 3), (4 + 5) and (6 + 7). These data enable elucidation of the mechanisms involved in regulation of the uPAR gene expression and provide further evidence that the uPAR gene belongs to the Ly-6 superfamily.
Fibrinogen regulates the expression of inflammatory chemokines through NF-κB activation of endothelial cells (2004)

The objective of this study was to characterize the role of fibrinogen in stimulating expression of inflammatory chemokines in endothelial cells through NF-kappaB activation. Human umbilical vein endothelial cells (HUVEC) were exposed to fibrinogen up to 3,000 microg/ml, and NF-kappaB activation was assessed using electrophoretic mobility shift assay (EMSA). Fibrinogen exposure resulted in a concentration dependent increase in NF-kappaB activation that reached a maximum at 1,000 microg/ml after 4 hours and was sustained up to 24 hours. The effect was inhibited by antibodies to alpha(v)beta(3) and alpha(5)beta(1) and by the GRGDS peptide, indicating integrin involvement. Preincubation with Mn(2+) lowered the fibrinogen concentration-dependence, consistent with integrin activation. Supershift assays demonstrated involvement of the p50, p65 and c-Rel components of NF-kappaB. Fibrinogen exposure also resulted in up-regulation of expression of monocyte chemoattractant protein-1 (MCP-1) and of interleukin-8 as shown by RNase protection assays and by real-time RT-PCR. Increased secretion of MCP-1 was confirmed by ELISA. Parthenolide, an IkappaB kinase inhibitor, prevented up-regulation of MCP-1 by fibrinogen, linking this response to NF-kappaB activation. From our findings, we conclude that fibrinogen regulates NF-kappaB activation and expression of inflammatory chemokines in endothelial cells and may be involved in mediating inflammatory processes.
Overexpression of Cytosolic Glutamine Synthetase. Relation to Nitrogen, Light, and Photorespiration (2002)

In plants, ammonium released during photorespiration exceeds primary nitrogen assimilation by as much as 10-fold. Analysis of photorespiratory mutants indicates that photorespiratory ammonium released in mitochondria is reassimilated in the chloroplast by a chloroplastic isoenzyme of glutamine synthetase (GS2), the predominant GS isoform in leaves of Solanaceous species including tobacco (Nicotiana tabacum). By contrast, cytosolic GS1 is expressed in the vasculature of several species including tobacco. Here, we report the effects on growth and photorespiration of overexpressing a cytosolic GS1 isoenzyme in leaf mesophyll cells of tobacco. The plants, which ectopically overexpress cytosolic GS1 in leaves, display a light-dependent improved growth phenotype under nitrogen-limiting and nitrogen-non-limiting conditions. Improved growth was evidenced by increases in fresh weight, dry weight, and leaf soluble protein. Because the improved growth phenotype was dependent on light, this suggested that the ectopic expression of cytosolic GS1 in leaves may act via photosynthetic/photorespiratory process. The ectopic overexpression of cytosolic GS1 in tobacco leaves resulted in a 6- to 7-fold decrease in levels of free ammonium in leaves. Thus, the overexpression of cytosolic GS1 in leaf mesophyll cells seems to provide an alternate route to chloroplastic GS2 for the assimilation of photorespiratory ammonium. The cytosolic GS1 transgenic plants also exhibit an increase in the CO(2) photorespiratory burst and an increase in levels of photorespiratory intermediates, suggesting changes in photorespiration. Because the GS1 transgenic plants have an unaltered CO(2) compensation point, this may reflect an accompanying increase in photosynthetic capacity. Together, these results provide new insights into the possible mechanisms responsible for the improved growth phenotype of cytosolic GS1 overexpressing plants. Our studies provide further support for the notion that the ectopic overexpression of genes for cytosolic GS1 can potentially be used to affect increases in nitrogen use efficiency in transgenic crop plants.
Ab initio LCAO hybrid density-functional method for accurate, large-scale electronic structure simulations of semiconductor materials, interfaces and gate stacks (2021)

We demonstrate an efficient method for high-accuracy ab initio simulations for semiconductor device technology development, such as high-k metal gate stack engineering and investigation of 2D material-based FET performance. The method combines the HSE06 hybrid density functional with linear combination of atomic orbitals (LCAO) basis sets, as implemented in the QuantumATK atomic-scale modeling platform. We show that HSE06-LCAO predicts accurate band energies and enables large-scale HSE06 simulations for systems comprising thousands of atoms using modest computational resources.
Age-Related Differences in Rabbits during ExperimentalStaphylococcus aureusKeratitis (2007)

Corneas and erythrocytes of young rabbits, relative to aged rabbits, are significantly more susceptible to S. aureus keratitis and to alpha-toxin.
High Performance Packet Processing with FlexNIC (2016)

The recent surge of network I/O performance has put enormous pressure on memory and software I/O processing sub systems. We argue that the primary reason for high memory and processing overheads is the inefficient use of these resources by current commodity network interface cards (NICs). We propose FlexNIC, a flexible network DMA interface that can be used by operating systems and applications alike to reduce packet processing overheads. FlexNIC allows services to install packet processing rules into the NIC, which then executes simple operations on packets while exchanging them with host memory. Thus, our proposal moves some of the packet processing traditionally done in software to the NIC, where it can be done flexibly and at high speed. We quantify the potential benefits of FlexNIC by emulating the proposed FlexNIC functionality with existing hardware or in software. We show that significant gains in application performance are possible, in terms of both latency and throughput, for several widely used applications, including a key-value store, a stream processing system, and an intrusion detection system.
Public-key Primitives (2008)

Wireless sensor networks consist of tiny senor nodes with limited computing and communicating capabilities and, more importantly, with limited energy resources. In this chapter we evaluate the power consumption of Public-key algorithms and investigate whether these algorithms can be used within the power constrained sensor nodes. We evaluate conventional digital signature schemes and encryption schemes, one-time signature schemes and Public-key authentication schemes.
TRPM8 Mechanism of Autonomic Nerve Response to Cold in Respiratory Airway (2008)

Breathing cold air without proper temperature exchange can induce strong respiratory autonomic responses including cough, airway constriction and mucosal secretion, and can exacerbate existing asthma conditions and even directly trigger an asthma attack. Vagal afferent fiber is thought to be involved in the cold-induced respiratory responses through autonomic nerve reflex. However, molecular mechanisms by which vagal afferent fibers are excited by cold remain unknown. Using retrograde labeling, immunostaining, calcium imaging, and electrophysiological recordings, here we show that a subpopulation of airway vagal afferent nerves express TRPM8 receptors and that activation of TRPM8 receptors by cold excites these airway autonomic nerves. Thus activation of TRPM8 receptors may provoke autonomic nerve reflex to increase airway resistance. This putative autonomic response may be associated with cold-induced exacerbation of asthma and other pulmonary disorders, making TRPM8 receptors a possible target for prevention of cold-associated respiratory disorders.
Complex Regional Pain Syndrome (CRPS): Survey of Current Practices (2004)

Our survey results revealed the use of a treatment algorithm for CRPS that consists of treatment using medical therapies (pharmacologic, blocks, catheters, and implantable devices), psychological therapies, and physiotherapy in a coordinated fashion. The trend among our survey respondents is to utilize increasingly interventional techniques after a failed 2- to 4-week trial of any one particular therapy.
Posibilidades del estuco y la tranferencia como nuevas técnicas y/o procedimientos pictóricos-dibujísticos (2013)

Nuestra investigaciones e centra en localizar (con determinada composicion a estudiar) el estuco mas idoneo aplicable a determinados soportes moviles. Indispensable la investigacion en la compatibilidad de dicho estuco, con determinados procedimientos graficos plasticos. Por otro lado, se planteara la transferencia fotografica - color o blanc o y negro como un nuevo procedimiento aplicable al estuco. Con todo ello obtendremos resultados variados y estableceremos relaciones soporte-tecnica para poder obtener el maximo potencial expresivo en cada caso, estudiando el comportamiento plastico que ambas tecnicas pueden tener por separado en un primer momento, y conjuntamente segun se avance en el estudio.
An Overview of Nonlinear Model Predictive Control Applications (2000)

This paper provides an overview of nonlinear model predictive control (NMPC) applications in industry, focusing primarily on recent applications reported by NMPC vendors. A brief summary of NMPC theory is presented to highlight issues pertinent to NMPC applications. Five industrial NMPC implementations are then discussed with reference to modeling, control, optimization, and implementation issues. Results from several industrial applications are presented to illustrate the benefits possible with NMPC technology. A discussion of future needs in NMPC theory and practice is provided to conclude the paper.
CITED2 Modulates Breast Cancer Metastatic Ability through Effects on IKKα (2016)

The current study highlights the role of CITED2 in facilitating breast cancer metastasis, partly via regulation of IKKα. Mol Cancer Res; 14(8); 730-9. ©2016 AACR.
Genomic characterization of the Atlantic cod sex-locus (2016)

A variety of sex determination mechanisms can be observed in evolutionary divergent teleosts. Sex determination is genetic in Atlantic cod (Gadus morhua), however the genomic location or size of its sex-locus is unknown. Here, we characterize the sex-locus of Atlantic cod using whole genome sequence (WGS) data of 227 wild-caught specimens. Analyzing more than 55 million polymorphic loci, we identify 166 loci that are associated with sex. These loci are located in six distinct regions on five different linkage groups (LG) in the genome. The largest of these regions, an approximately 55 Kb region on LG11, contains the majority of genotypes that segregate closely according to a XX-XY system. Genotypes in this region can be used genetically determine sex, whereas those in the other regions are inconsistently sex-linked. The identified region on LG11 and its surrounding genes have no clear sequence homology with genes or regulatory elements associated with sex-determination or differentiation in other species. The functionality of this sex-locus therefore remains unknown. The WGS strategy used here proved adequate for detecting the small regions associated with sex in this species. Our results highlight the evolutionary flexibility in genomic architecture underlying teleost sex-determination and allow practical applications to genetically sex Atlantic cod.
HOW COMMON IS PROSTATITIS? A NATIONAL SURVEY OF PHYSICIAN VISITS (1998)

Genitourinary symptoms are a frequent reason for office visits by younger and older men, and prostatitis is a common diagnosis. Despite a report that less than 10% of prostatitis cases are bacterial, a much higher proportion of men in whom prostatitis is diagnosed receive antimicrobials.
Photochromism-Induced Amplification of Critical Current Density in Superconducting Boron-Doped Diamond with an Azobenzene Molecular Layer (2014)

A key issue in molecular electronics is the control of electronic states by optical stimuli, which enables fast and high-density data storage and temporal-spatial control over molecular processes. In this article, we report preparation of a photoswitchable superconductor using a heavily boron-doped diamond (BDD) with a photochromic azobenzene (AZ) molecular layer. BDDs electrode properties allow for electrochemical immobilization, followed by copper(I)-catalyzed alkyne-azide cycloaddition (a "click" reaction). Superconducting properties were examined with magnetic and electrical transport measurements, such as field-dependent isothermal magnetization, temperature-dependent resistance, and the low-temperature voltage-current response. These measurements revealed reversible amplification of the critical current density by 55% upon photoisomerization. This effect is explained as the reversible photoisomerization of AZ inducing an inhomogeneous electron distribution along the BDD surface that renormalizes the surface pinning contribution to the critical current.
Celosia argentea L. (1998)

https://thekeep.eiu.edu/herbarium_specimens_byname/4228/thumbnail.jpg
Gsh2 and Pax6 play complementary roles in dorsoventral patterning of the mammalian telencephalon (2001)

The telencephalon has two major subdivisions, the pallium and subpallium. The pallium, which primarily consists of glutamatergic cortical structures, expresses dorsal molecular markers, whereas the subpallium, which primarily consists of the GABAergic basal ganglia, expresses ventral molecular markers. Here, we present evidence that the progenitor and postmitotic cells flanking the pallial/subpallial boundary (PSB) in the embryonic mouse can be subdivided into multiple regions that express unique combinations of transcription factors. The domains that immediately flank the PSB are the ventral pallium (VP) and the dorsal lateral ganglionic eminence (dLGE). The early expression of the Pax6 and Gsh2 homeobox transcription factors overlaps in the region of the dLGE. Analyses of mice that lack functional alleles of either Gsh2 or Pax6 demonstrate that these genes have complementary roles in patterning the primordia flanking the PSB. In the Gsh2 mutants, the dLGE is respecified into a VP-like structure, whereas in the Pax6 mutants the VP is respecified into a dLGE-like structure. The role of Pax6 in dorsalizing the telencephalon is similar to its role in the spinal cord, supporting the hypothesis that some dorsoventral patterning mechanisms are used at all axial levels of the central nervous system.
Isomeric pyrimidinecarboxylic acids as electron-mediating bridging ligands in the inner-sphere reduction of cobalt(III) by chromium(II) (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIsomeric pyrimidinecarboxylic acids as electron-mediating bridging ligands in the inner-sphere reduction of cobalt(III) by chromium(II)H. Bertram, E. Boelsing, H. Spiecker, and K. WieghardtCite this: Inorg. Chem. 1978, 17, 2, 221–224Publication Date (Print):February 1, 1978Publication History Published online1 May 2002Published inissue 1 February 1978https://pubs.acs.org/doi/10.1021/ic50180a004https://doi.org/10.1021/ic50180a004research-articleACS PublicationsRequest reuse permissionsArticle Views38Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Thermocrinis (2015)

Abstract Ther.mo.cri'nis. Gr. fem. n. therme heat; L. masc. n. crinis hair; M.L. masc. n. Thermocrinis hot hair. Rod‐shaped cells with rounded ends, about 1–3 × 0.4–0.5 µm. The rods occur singly, in pairs, in aggregates or as long filaments . Double‐layered cell envelope. Diaminopimelic acid present . Non‐sporulating. Gram negative . Motile by monopolar polytrichous flagellation. Microaerophilic. Hyperthermophilic , optimum growth temperature, 80°C; maximum 89°C; minimum, 44°C. Growth at 0–0.4% NaCl and at pH 7 and 8.5. Growth occurs on solid surfaces. Chemolithoautotrophic or chemoorganoheterotrophic metabolism . The mol % G + C of the DNA is : 47.2–47.8. Type species : Thermocrinis ruber Huber, Eder, Heldwein, Wanner, Huber, Rachel and Stetter 1999, 341 (Effective publication: Huber, Eder, Heldwein, Wanner, Huber, Rachel and Stetter 1998c, 3582.) Taxonomic and Nomenclature Notes According to the List of Prokaryotic names with Standing in Nomenclature (LPSN), the taxonomic status of the genus Thermocrinis is: correct name (last update, February 2025) * . LPSN classification: Bacteria / Pseudomonadati / Aquificota / Aquificia / Aquificales / Aquificaceae / Thermocrinis The genus Thermocrinis can also be recovered in the Genome Taxonomy Database (GTDB) as g__Thermocrinis (version v220) ** . GTDB classification: d__Bacteria / p__Aquificota / c__Aquificae / o__Aquificales / f__Aquificaceae / g__Thermocrinis * Meier‐Kolthoff et al. ( 2022 ). Nucleic Acids Res , 50 , D801 – D807 ; DOI: 10.1093/nar/gkab902 ** Parks et al. ( 2022 ). Nucleic Acids Res , 50 , D785 – D794 ; DOI: 10.1093/nar/gkab776
Inkjet-printed perovskite distributed feedback lasers (2018)

We report on digitally printed distributed feedback lasers on flexible polyethylene terephthalate substrates based on methylammonium lead iodide perovskite gain material. The perovskite lasers are printed with a digital drop-on-demand inkjet printer, providing full freedom in the shape and design of the gain layer. We show that adjusting the perovskite ink increases the potential processing window and decreases the surface roughness of the active layer to less than 7 nm, which is essential for low lasing thresholds. Prototype inkjet-printed perovskite lasers processed on top of nanopatterned rigid as well as flexible substrates are demonstrated. Optimized perovskite gain layers printed on PET substrates demonstrated lasing and showed a linewidth of 0.4 nm and a lasing threshold of 270 kW/cm<sup>2</sup>. In addition, printing of a distinct shape shows a high level of uniformity, demonstrated by a low spatial resolved full width half maximum variation over the whole printing area. These results reveal the possibilities of digital printed perovskite layers towards large-scale and low-cost laser applications of arbitrary shape.
A Life-After-Life Vision for Improved Psyches and Their Inevitable Addictions (2022)

Previous work has highlighted basic problems with the scientific model of life, in particular about health and behavioral tendencies. A possible explanation was introduced involving a reincarnation- (or transcendental-) based understanding of life. Associated with that premodern understanding of life (and death) was potential insight into a number of behavioral enigmas; a more constructive vision; and consistency with a number of religions on the opportunity for deeper meaning and a profound release (or transcendence) from suffering. Herein this approach is furthered via discussions on - the modern default understanding, scientific materialism; reviews of reincarnation research; our innate religious/spiritual beliefs; and medium-based communications with the dead. The closing discussion and conclusions then summarize the basic points herein, consider some implications, and offer a few suggestions. If people want to address our challenging mental circumstances, they should consider looking beyond the contemporary paradigm.
Fleet-Level Environmental Assessments for Feasibility of Aviation Emission Reduction Goals (2022)

The International Air Transport Association (IATA) is one of several organizations that have presented goals for future CO2 emissions from commercial aviation with the intent of alleviating the associated environmental impacts. These goals include attaining carbon-neutral growth in the year 2020 and total aviation CO2 emissions in 2050 equal to 50% of 2005 aviation CO2 emissions. This paper presents the use of a simulation-based approach to predict future CO2 emissions from commercial aviation based upon a set of scenarios developed as part of the Aircraft Technology Modeling and Assessment project within ASCENT, the FAA Center of Excellence for Alternative Jet Fuels and the Environment. Results indicate that, in future scenarios with increasing demand for air travel, it is difficult to reduce CO2 emissions in 2050 to levels equal to or below 2005 levels, although neutral CO2 growth after 2020 may be possible.
ChemInform Abstract: N‐Heterocyclic Carbene (NHC)—Copper(I) Complexes as Catalysts for A3 Reactions. (2013)

Abstract A facile synthesis of a broad spectrum of propargylamines can be achieved, in part at room temperature and within a short time, in the presence of a copper carbene complex as the catalyst.
Distributed IR based technology to monitor hand hygiene of healthcare staff (2009)

An electronic system to increase compliance with hand hygiene rules and clinical tests which demonstrated the function and acceptability of the system are described.