gebhart/patrepeval huggingface dataset:
Use of targeted array‐based CGH for the clinical diagnosis of chromosomal imbalance: Is less more? (2005)

Chromosome analysis is an important component to the diagnosis of congenital anomalies, developmental delay, and mental retardation. Routine chromosome analysis identifies aneuploidy and structural rearrangements greater than 5 Mb but cannot identify abnormalities of the telomeric regions or microdeletions reliably. Molecular cytogenetic techniques were developed to overcome these limitations. High-resolution comparative genomic hybridization (CGH)-based microarrays (array CGH) were developed to increase the resolution of chromosomal studies and to provide a comprehensive assay by using large-insert clones as the target for analysis. We constructed a microarray for the clinical diagnosis of medically significant and relatively common chromosomal alterations. Nine hundred six bacterial artificial chromosome (BAC) clones were chosen, the chromosomal locations of which were confirmed by fluorescence in situ hybridization (FISH). FISH-testing showed that 7% of the clones were mismapped based on map locations obtained from two publicly available databases (58 mapped to the wrong chromosome and three mapped to a different locus on the same chromosome), 16% cross-hybridized to other chromosomes, and 12% did not hybridize or showed poor hybridization signals under uniform FISH conditions. Thus, from a total of 906 BAC clones that were evaluated, only 589 (65%) were deemed adequate for arraying on this clinical device. The performance of this array was tested in a set of blinded experiments on a cohort of phenotypically normal individuals and on individuals with known chromosome abnormalities. The array identified deletion/duplication polymorphisms not seen by FISH in the phenotypically normal individuals and detected single copy dosage differences in all of the cases with known chromosomal abnormalities. All abnormalities detected by the array were confirmed by FISH with BACs from the appropriate loci. Our data demonstrate that the rigorous assessment of BACs and their use in array CGH is especially important when the microarray is used for clinical diagnosis. In addition, this study illustrates that when constructed carefully with proper attention to the quality of the BACs that are arrayed, array CGH is an effective and efficient tool for delineating chromosomal aberrations and an important adjunct to FISH and conventional cytogenetics.
The oesophageal detector device (1989)

Misplacement of a tracheal tube in the oesophagus remains a significant cause of mortality and morbidity in anaesthesia, despite decades of effort aimed at prevention, or perhaps more importantly, detection, of such an event. We have evaluated a cheap, simple and quick device which relies mainly on the reflation or otherwise of an Ellick's evacuator applied to the supposed 'tracheal' tube. Identical tracheal tubes were passed into the trachea and oesophagus of 100 patients; the left and right position in the mouth was chosen at random. The test was conducted by a second anaesthetist, not present at intubation, and unaware of which tube was in the trachea. There were no false positive results and the correct deduction of which was the tracheal tube was reached in 100 tests using this device. Its use is recommended for widespread evaluation as a valuable adjunct to existing methods of detecting misplacement.
Electronically reconfigurable metamaterial for compact directive cavity antennas (2007)

The modelling and characterisation of an electronically controllable metamaterial partially reflecting surface to a resonant cavity antenna near 8 GHz is considered. The metamaterial considered is composed of a composite phase varying metamaterial, by the insertion of active electronic components, and is proposed for the design of the reconfigurable Fabry-Perot cavity antenna. An adjustable resonance frequency between 7.9 and 8.2 GHz is obtained and a drastic enhancement in the directivity of the antenna is also observed for a cavity thickness as small as λ/75.
Synthesis of Structurally Simplified Analogues of Pancratistatin: Truncation of the Cyclitol Ring (2009)

Pancratistatin is a phenanthridone-type natural product isolated from several plants of the Amaryllidaceae family. Its potent antiproliferative, antivascular, antiviral, and antiparasitic properties have attracted the attention of synthetic, biological, and medicinal chemists. Pancratistatin's low natural availability and complex structure have steered many of these research projects toward the preparation of its simplified synthetic analogues with useful levels of activity. In this work we have developed synthetic chemistry aimed at the preparation of pancratistatin analogues with a truncated cyclitol portion of the molecule. The described synthetic pathways are based on a highly anti-diastereoselective arylcuprate conjugate addition to gamma-alkoxy-alpha,beta-enoates and syn-selective azidation at the alpha-position of ester enolates. Analogues with the formally cleaved C3-C4 bond, and thus containing an open ring C, as well as a compound containing a truncated lactol moiety in lieu of the cyclitol, were prepared. Several of the analogues exhibited weak antiproliferative activity, with the highest potency observed in the case of the lactol analogue. From these results implications for the design of future pancratistatin analogues are discussed. Furthermore, the synthetic pathways can be used to construct pancratistatin-mimetic libraries, in which the cyclitol moiety is replaced by other cyclic motifs.
Polymeric Micelles with Ionic Cores Containing Biodegradable Cross-Links for Delivery of Chemotherapeutic Agents (2010)

Novel functional polymeric nanocarriers with ionic cores containing biodegradable cross-links were developed for delivery of chemotherapeutic agents. Block ionomer complexes (BIC) of poly(ethylene oxide)-b-poly(methacylic acid) (PEO-b-PMA) and divalent metal cations (Ca(2+)) were utilized as templates. Disulfide bonds were introduced into the ionic cores by using cystamine as a biodegradable cross-linker. The resulting cross-linked micelles with disulfide bonds represented soft, hydrogel-like nanospheres and demonstrated a time-dependent degradation in the conditions mimicking the intracellular reducing environment. The ionic character of the cores allowed to achieve a very high level of doxorubicin (DOX) loading (50% w/w) into the cross-linked micelles. DOX-loaded degradable cross-linked micelles exhibited more potent cytotoxicity against human A2780 ovarian carcinoma cells as compared to micellar formulations without disulfide linkages. These novel biodegradable cross-linked micelles are expected to be attractive candidates for delivery of anticancer drugs.
Stochastic Adaptive Tracking In A Camera Network (2007)

We present a novel stochastic, adaptive strategy for tracking multiple people in a large network of video cameras. Similarities between features (appearance and biometrics) observed at different cameras are continuously adapted and the stochastically optimal path for each person computed. The following are the major contributions of the proposed approach. First, we consider situations where the feature similarities are uncertain and treat them as random variables. We show how the distributions of these random variables can be learned and how to compute the tracks in a stochastically optimal manner. Second, we consider the possibility of long-term interdependence of the features over space and time. This allows us to adoptively evolve the feature correspondences by observing the system performance over a time window, and correct for errors in the similarity computations. Third, we show that the above two conditions can be addressed by treating the issue of tracking in a camera network as an optimization problem in a stochastic adaptive system. We show results on data collected by a large camera network. The proposed approach is particularly suitable for distributed processing over the entire network.
Enlarged near-field optical imaging (2009)

Millimeter scale near-field optical microscopy is here reported. It is demonstrated in the near infrared by observing light propagating in an integrated glass waveguide. Enlarged near-field imaging was made possible thanks to the use of a homemade interferometric translation stage with nanometric scale repeatabilities combined with a commercial atomic force microscope. An integrated optical component was used as a representative example of multiscale components requiring large scale highly resolved optical mapping. By imaging stationary waves on a millimeter long range followed by Fourier analysis, an uncertainty of a few 10−4 on the waveguide modes effective index was obtained. While improving the optogeometrical parameter retrieval precision, millimeter scans make the technique sensitive to properties such as birefringence.
Applications of Spectrophotometric Measurement in Dyeing and Finishing (1965)

Presented at a Symposium on 'Modem Methods of Control in Dyeing and Finishing held by the Scottish Region in the Royal College of Science and Technology, Glasgow, on 3rd April 1964, Mr J. Bruce Jones in the chair, and (i n part) at a meeting of the Manchester Junior Section held at the College of Science and Technology, Manchester, on 25th February1965 The important applications of spectrophotonietry dependent upon Beer's Law are discussed and a number of spectrophotometers suitable for the examination of dye solutions are mentioned. Equipment that has been used with recording spectrophotometers for the investigation of dyeing behaviour is described. Whilst reflection or transmission curves from spectrophotometric measurements may be converted to tristimulus values (A, Y, Z) in the CIE system, direct measurements of A, Y, 2 by means of suitable photoelectric colorimeters, a number of which are suggested, may be made. Reference is made to colour‐difference formulae and their applications. An equation, based on the Kubelka‐Munk theory, relating reflectance, at a given wave‐ length to dye concentration on the fibre is stated. Applications, including instrumental colour‐match prediction, are discussed, and a brief survey of instrumental matching methods is presented. Probable future developments in the application of computer
Oxidation of Si by Microwave-Excited Oxygen-Plasma through Protective Al Coating (1986)

An Al film was formed as a protective layer on a Si wafer. Oxidizing species generated in a microwave-excited oxygen-plasma penetrated the Al protective layer under a UV-light irradiation. The depth profile of the chemical composition of the oxidized film was measured by XPS with Ar-ion sputtering. It was found that the UV-light enhances the oxidation rate through a surface excitation. In O 2 +N 2 mixture plasma, intermixed-insulator films on Si (SiO 2 -Al 2 O 3 -SiO 2 -Si substrate) were prepared by one sequential plasma process. In O 2 +H 2 mixture plasma, the inner SiO 2 layer was not recognized.
Response to Comment on "Nervy Links Protein Kinase A to Plexin-Mediated Semaphorin Repulsion" (2005)

The comment by Ice et al . ([ 1 ][1]) questions conclusions we drew concerning the function of the Drosophila protein Nervy ([ 2 ][2]). They state that the polyclonal antibody anti-ETO Ab-1, directed against the mammalian ortholog of Nervy ETO/MTG8, does not recognize Drosophila Nervy. We purchased
ChemInform Abstract: AN IMPROVED SYNTHESIS OF NATURALLY OCCURRING COUMARINS: SYNTHESIS OF HERNIARIN, SCOPARONE AND 7‐METHOXY‐6‐METHYLCOUMARIN (1983)

Abstract Vi1smeier‐Haack‐Reaktion der Benzole (I) liefert die Aldehyde (II), die nach Demethylierung die Hydroxyaldehyde (III) ergeben.
pH-Dependent, Stereoselective Dimerization of Sinomenine (2008)

In a continuing study on discovery of more potent derivatives of sinomenine (1), a clinically available alkaloid for rheumatoid arthritis (RA) treatment, oxidation of sinomenine provided two unique stereoisomers, disinomenines 2 and 3. The structure of 3 was determined by MS, NMR, and X-ray analysis. The formation of 2 and 3 via oxidation of sinomenine by potassium permanganate (KMnO4) exhibited a pH-dependent stereoselectivity. The bioassay results using human synovial sarcoma cells (SW982) showed that 2 inhibited, while 3 stimulated, IL-6 production.
Parallel 2-D Convolution on a Mesh Connected Array Processor (1987)

In this correspondence, a parallel 2-D convolution scheme is presented. The processing structure is a mesh connected array processor consisting of the same number of simple processing elements as the number of pixels in the image. For most windows considered, the number of computation steps required is the same as that of the coefficients of a convolution window. The proposed scheme can be easily extended to convolution windows of arbitrary size and shape. The basic idea of the proposed scheme is to apply the 1-D systolic concept to 2-D convolution on a mesh structure. The computation is carried out along a path called a convolution path in a systolic manner. The efficiency of the scheme is analyzed for windows of various shapes. The ideal convolution path is a Hamiltonian path ending at the center of the window, the length of which is equal to the number of window coefficients. The simple architecture and control strategy make the proposed scheme suitable for VLSI implementation.
Ambient FM backscattering for smart agricultural monitoring (2017)

Nowadays the measurement of moisture level in plants is critical for agriculture. One way to detect this is to measure the temperature difference between the leaf and the air. This paper introduces a novel wireless leaf temperature sensor that utilizes ambient FM backscattering for smart agricultural applications. The sensor is based on an ultra low power micro-controller, a sensor board and a RF front-end for wireless communication. The sensor communicates using backscatter radio principles on ambient FM station signals using AM modulation with FM0 encoding. The prototype featured an effective operation up to ranges of 0.5 m by backscattering sensor information at 50 bps and 500 bps using an ambient FM radio signal inside a laboratory setup. A high percentage of bits was clearly visible up to 2 m at 50 bps.
Multimodal Retinal Image Registration for Optic Disk Segmentation (2004)

We have developed a method for the registration of images of the scanning laser tomograph and fundus photographs. Our first experiments showed that the optic disk segmentation could be improved by fused information from both image modalities.
Steroidal Sapogenins. LXIV. C-21 Acetoxylation of 12-Keto Steroids2 (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSteroidal Sapogenins. LXIV. C-21 Acetoxylation of 12-Keto Steroids2EDWARD S. ROTHMAN, THEODORE PERLSTEIN, and MONROE E. WALLCite this: J. Org. Chem. 1960, 25, 11, 1966–1968Publication Date (Print):November 1, 1960Publication History Published online1 May 2002Published inissue 1 November 1960https://pubs.acs.org/doi/10.1021/jo01081a036https://doi.org/10.1021/jo01081a036research-articleACS PublicationsRequest reuse permissionsArticle Views124Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Cell and Ultrastructure, A Functional Perspective (1995)

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Online Surge Testing Applied to an Induction Machine With Emulated Insulation Breakdown (2013)

A breakdown of the electrical insulation system can cause catastrophic failure of the electrical machine and bring large process downtime losses. Preventive maintenance and online monitoring are some of the methods to improve reliability and reduce unscheduled downtime. The offline surge test is the most commonly used offline test to assess the condition of the turn insulation. There is no online monitoring method that is applicable to low-voltage machines and has the same capabilities as the surge test. This paper shows how to conduct a surge test online on 460-V/230-V rated induction machines that are connected in the low-voltage configuration. The required hardware, test procedures, and evaluation of the results are described. Instead of using a bolted short to emulate the insulation breakdown, a new approach is used for the experimental validation. The arcing is emulated either by using an insulation sample that breaks down at a certain test voltage or by using a circuit that emulates the breakdown.
Path Analysis for Distance Learning with E-Learning (2020)

In today’s digital age, information technology is a strategic resource for universities in the era of rapid competition. The purpose of this study is to understand the influence of information technology, learning attitude, learning satisfaction, students’ learning motivation, and learning achievement by path analysis, and to provide a reference for universities to promote an overall quality of learning and teaching. A total of seventy-five questionnaires were distributed in this study, and the effective questionnaire returned rate was 100%. The results showed that :(1) there was a significant positive impact between information technology (as e-learning) and learning motivation. (2) there was a significant positive impact between learning motivation and learning achievement. (3) there was a significant positive impact between learning attitude and learning motivation. (4) there was a significant positive impact between learning satisfaction and learning motivation.
Thermal stability of a star‐shaped poly(1,3‐cyclohexadiene) (2009)

Abstract A star‐shaped poly(1,3‐cyclohexadiene) (PCHD) with a fullerene‐C 60 (C 60 ) core (C 60 ‐PCHD) was prepared to examine the thermal stability of the covalent bond between the C 60 and PCHD arm in the C 60 ‐PCHD. The covalent bond between the C 60 and PCHD arm formed by a 1,2‐cyclohexadiene (CHD) unit on the C 60 was stronger than that formed by a 1,4‐CHD unit. The double bond in the CHD unit adjoining the C 60 core was a key structure for the stability of that covalent bond. The hydrogenated C 60 ‐PCHD, which did not contain a double bond, possessed significantly higher thermal stability compared to C 60 ‐PCHD. The mechanism of elimination of PCHD arm molecules from the C 60 core was thought to proceed via a 1,5‐sigmatropic H‐shift. © 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 47: 2132–2142, 2009
Web based progressive transmission for browsing remotely sensed imagery (2002)

This paper describes an image representation technique that entails progressive refinement of user specified regions of interest (ROI) of large images. Progressive refinement to original quality can be accomplished in theory. However, due to heavy burden on storage resources for the authors' applications, they restrict the refinement to about 25% of the original data resolution. A wavelet decomposition of the data combined with scalar and vector quantization (VQ) of the high frequency components and JPEG/DCT compression of low frequency component is used as representation framework. Their software will reconstruct the region selected by the user from its wavelet decomposition such that it fills up the preview window with the appropriate subimages at the desired resolution, including full resolution stored for preview. Further refinement from the first preview can be obtained progressively by transmitting high frequency coefficients from low resolution to high resolution which are compressed by variant of vector quantization called model-based VQ (MVQ). The user will have an option for progressive build up of the ROIs until full resolution stored or terminate the transmission at any time during the progressive refinement.
Characterization of a phospholipid adsorbed layer on silica from small unilamellar vesicles (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCharacterization of a phospholipid adsorbed layer on silica from small unilamellar vesiclesKunio Esumi and Toshinori YamadaCite this: Langmuir 1993, 9, 2, 622–624Publication Date (Print):February 1, 1993Publication History Published online1 May 2002Published inissue 1 February 1993https://pubs.acs.org/doi/10.1021/la00026a044https://doi.org/10.1021/la00026a044research-articleACS PublicationsRequest reuse permissionsArticle Views80Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Novel Second-Generation Di-2-Pyridylketone Thiosemicarbazones Show Synergism with Standard Chemotherapeutics and Demonstrate Potent Activity against Lung Cancer Xenografts after Oral and Intravenous Administration in Vivo (2012)

We developed a series of second-generation di-2-pyridyl ketone thiosemicarbazone (DpT) and 2-benzoylpyridine thiosemicarbazone (BpT) ligands to improve the efficacy and safety profile of these potential antitumor agents. Two novel DpT analogues, Dp4e4mT and DpC, exhibited pronounced and selective activity against human lung cancer xenografts in vivo via the intravenous and oral routes. Importantly, these analogues did not induce the cardiotoxicity observed at high nonoptimal doses of the first-generation DpT analogue, Dp44mT. The Cu(II) complexes of these ligands exhibited potent antiproliferative activity having redox potentials in a range accessible to biological reductants. The activity of the copper complexes of Dp4e4mT and DpC against lung cancer cells was synergistic in combination with gemcitabine or cisplatin. It was demonstrated by EPR spectroscopy that dimeric copper compounds of the type [CuLCl](2), identified crystallographically, dissociate in solution to give monomeric 1:1 Cu:ligand complexes. These monomers represent the biologically active form of the complex.
Fast synchronization for chip multiprocessors (2005)

This paper presents a novel mechanism for barrier synchronization on chip multi-processors (CMPs). By forcing the invalidation of selected I-cache lines, this mechanism starves threads and thus forces their execution to stop. Threads are let free when all have entered the barrier.We evaluated this mechanism using SMTSim and report much better (and most importantly, more flat) performance than lock-based barriers supported by existing microprocessors.