gebhart/patrepeval huggingface dataset:
Emotional Musical Prosody: Validated Vocal Dataset for Human Robot Interaction (2020)

Human collaboration with robotics is dependant on the development of a relationship between human and robot, without which performance and utilization can decrease. Emotion and personality conveyance has been shown to enhance robotic collaborations, with improved human-robot relationships and increased trust. One under-explored way for an artificial agent to convey emotions is through non-linguistic musical prosody. In this work we present a new 4.2 hour dataset of improvised emotional vocal phrases based on the Geneva Emotion Wheel. This dataset has been validated through extensive listening tests and shows promising preliminary results for use in generative systems.
Diagnosis and current management of Crohn's disease (2007)

Crohn′s disease is a chronic inflammatory disease that can affect any part of the gastrointestinal tract, from mouth to anus. Extra-intestinal presentations, although less common, can also occur. Diagnosis may therefore be difficult as the presentation can differ greatly between patients. This can be a stressful time for patients, who may have debilitating symptoms and no diagnosis. There are various treatment options, but they do not offer a cure. This article provides a brief overview of current management strategies for Crohn′s disease.
Gd-admixed (Lu,Gd)AlO3 single crystals: breakthrough in heavy perovskite scintillators (2021)

Abstract We report a breakthrough concept for a bulk single crystal as a heavy aluminum perovskite scintillator, where due to bandgap engineering by a balanced Gd admixture in a Lu cation sublattice, the scintillation performance dramatically increases. In an optimized composition of (Lu, Gd)AlO 3 :Ce (LuGdAP:Ce), the light yield approaches 21,000 phot/MeV, which is close to that of classical but much less dense YAP:Ce and 50% higher than the best LuYAP:Ce reported in the literature. Moreover, contrary to LuYAP:Ce, the LuGdAP host maintains a high effective atomic number close to that of LuAP:Ce (Z eff = 64.9), which is comparable to commercial LSO:Ce. An enormous decrease in afterglow on the millisecond time scale and acceleration in the rise time of the scintillation response further increase the application potential of the LuGdAP host. The related acceleration of the transfer stage in the scintillation mechanism due to diminishing electron trap depths is proven by thermally stimulated luminescence (TSL). Furthermore, we quantitatively characterize and model the energy transfer processes that are responsible for the change in the photoluminescence and scintillation decay kinetics of Ce 3+ in the LuGdAP matrix. Such an innovative (Lu, Gd)AP:Ce scintillator will become competitive for use in applications that require heavy, fast, and high light yield bulk scintillators.
Effects of field-induced hole-density modulation on normal-state and superconducting transport inYBa2Cu3O7−x (1992)

The hole-density dependence of the normal-state resistivity and transition temperature ${\mathit{T}}_{\mathit{c}}$ of ${\mathrm{YBa}}_{2}$${\mathrm{Cu}}_{3}$${\mathrm{O}}_{7\mathrm{\ensuremath{-}}\mathit{x}}$ was studied using the electric field effect in ultrathin films of 1 to 8 unit cells thickness. The change in resistivity was found to be equal to the field-induced variation in the areal carrier density, leading to a relation that the conductivity is proportional to the hole density. A similar linear dependence was also found in ${\mathit{T}}_{\mathit{c}}$. However, a saturation occurred in both cases but at different hole densities. The result reveals different effects of hole filling in influencing normal-state and superconducting transport of ${\mathrm{YBa}}_{2}$${\mathrm{Cu}}_{3}$${\mathrm{O}}_{7\mathrm{\ensuremath{-}}\mathit{x}}$.
Supplementary Figure Legend from Proteolytic Cleavage of Protein Tyrosine Phosphatase μ Regulates Glioblastoma Cell Migration (2023)

Supplementary Figure Legend from Proteolytic Cleavage of Protein Tyrosine Phosphatase μ Regulates Glioblastoma Cell Migration
Supplementary Figure S2 from Thyroid Cancers Exhibit Oncogene-Enhanced Macropinocytosis that Is Restrained by IGF1R and Promote Albumin–Drug Conjugate Response (2023)

&lt;p&gt;Assessment of albumin-bound chemotherapy efficacy and toxicity&lt;/p&gt;
Function Optimization and Event Clustering by Adaptive Differential Evolution (2002)

차분 진화는 다양한 형태의 목적함수를 최적화하는데 매우 효율적인 방법임이 입증되었다 차분 진화의 가장 큰 이점은 개념적 단순성과 사용의 용이성이다. 그러나 차분 진화의 수렴성이 제어 파라미터에 매우 민감한 단점이 있다. 본 논문은 새로운 교배용 벡터 생성법과 제어 파라미터의 적응 메커니즘을 결합한 적응성 있는 차분 진화를 제안한다. 이는 수렴성을 해치지 않으면서 차분 진화를 보다 강인하게 만들며 사용이 쉽도록 해준다. 12가지 최적화 문제에 대해 제안한 방법을 시험하였다. 적응성 있는 차분 진화의 응용 사례로써 이벤트 예측을 위한 교사 클러스터링 방법을 제안한다. 이 방법을 진화에 의한 이벤트 클러스터링이라 부르며 데이터 모델링 검증에 널리 사용되는 4 가지 사례에 대해 그 성능을 시험하였다. Differential evolution(DE) has been preyed to be an efficient method for optimizing real-valued multi-modal objective functions. DE's main assets are its conceptual simplicity and ease of use. However, the convergence properties are deeply dependent on the control parameters of DE. This paper proposes an adaptive differential evolution(ADE) method which combines with a variant of DE and an adaptive mechanism of the control parameters. ADE contributes to the robustness and the easy use of the DE without deteriorating the convergence. 12 optimization problems is considered to test ADE. As an application of ADE the paper presents a supervised clustering method for predicting events, what is called, an evolutionary event clustering(EEC). EEC is tested for 4 cases used widely for the validation of data modeling.
Beamforming Techniques for Multichannel audio Signal Separation (2012)

Beamforming is a signal processing technique.It has been studied in many areas such as radar, sonar, seismology and wireless communications, to name but a few.It can be used for a myriad of purposes, such as detecting the presence of a signal, estimating the direction of arrival, and enhancing a desired signal from its measurements corrupted by noise, competing sources and reverberation.Actually, Beamforming has been adopted by the audio research society, mostly to separate or extract speech for noisy environment.Beamforming techniques basically approach the problem from a spatial point of view.A microphone array is used to form a spatial filter which can extract a signal from a specific direction and reduce the contamination of signals from other directions.In this paper we survey some Beamforming techniques used for multichannel audio signal separation.
The effect of reproductive loss on the performance of a research flock (2020)

The reproductive performance of a sheep flock is dependent on a multitude of complex interacting factors. Achieving optimal flock performance requires knowledge of the reproductive steps and how these are linked and related to available measurements of the state and performance of the flock. The goal was to use previously collected data from a research flock that had undergone selection for fecundity (11,369 lambing records), to model the key reproductive steps affecting flock reproductive performance. The model was used to investigate how changes in liveweight, age, ovulation rate, number of fetuses at midpregnancy, number of lambs born, and birthweight affect the number of lambs weaned and the weaning weight of each lamb in this flock. The data available from the research flock were used to parameterize models of each reproductive step and assess the role of ewe age and premating liveweight on each reproductive step. These models were then linked together as a simulation tool to assess the role of different parameters on flock reproductive performance, which was defined as the total weight of lambs weaned per ewe exposed to the ram. Flock elasticities were calculated that characterize the relative importance of the effect of average premating ewe liveweight (0.81), average ovulation rate (0.33), variance in ovulation rate (-0.095), embryo survival (0.72), lamb survival (1.03), conception failure (0.35), and average ewe age (0.056) on the total kilograms of lamb liveweight at weaning per ewe exposed to the ram. The largest elasticity for lamb survival indicated that a 1% increase in lamb survival is expected to have a 1.03% increase in the total kilograms of lamb liveweight at weaning per ewe exposed to the ram in this flock. Assuming similar costs, interventions to increase lamb survival for this flock will provide the largest increase in the total kilograms of lamb liveweight at weaning per ewe exposed to the ram, which is a key metric of flock performance.
The WxxxE effector EspT triggers expression of immune mediators in an Erk/JNK and NF-κB-dependent manner (2011)

Enteropathogenic Escherichia coli (EPEC), enterohaemorrhagic E. coli (EHEC) and Citrobacter rodentium colonize their respective hosts while forming attaching and effacing lesions. Their infection strategy relies on translocation of a battery of type III secretion system effectors, including Map, EspM and EspT, which belong to the WxxxE/SopE family of guanine nucleotide exchange factors. Using the C. rodentium mouse model we found that EspT triggers expression of KC and TNFα in vivo. Indeed, a growing body of evidence suggests that, in addition to subversion of actin dynamics, the SopE and the WxxxE effectors activate signalling pathways involved in immune responses. In this study we found that EspT induces expression of the pro-inflammatory mediators cyclooxygenase-2 (COX-2) an enzyme involved in production of prostaglandin E(2) (PGE2), interleukin (Il)-8 and Il-1β in U937 human macrophages by activating the nuclear factor kappa-B (NF-κB), the extracellular signal-regulated kinases 1 and 2 (Erk1/2) and c-Jun N-terminal kinase (JNK) pathways. Since EspT modulates the activation of Cdc42 and Rac1, which mediates bacterial invasion into epithelial cells, we investigated the involvement of these Rho GTPases and bacterial invasion on pro-inflammatory responses and found that (i) Rac1, but not Cdc42, is involved in EspT-induced Il-8 and Il-1β secretion and (ii) cytochalasin D inhibits EspT-induced EPEC invasion into U937 but not Il-8 or Il-1β secretion. These results suggest that while EPEC translocates a number of effectors (i.e. NleC, NleD, NleE, NleH) that inhibit inflammation, a subset of strains, which encode EspT, employ an infection strategy that also involves upregulation of immune mediators.
Optimal Burst Scheduling in Optical Burst Switched Networks (2007)

Optical burst switching (OBS) is an emerging technology that allows variable size data bursts to be transported directly over dense wavelength division multiplexing links. In order to make OBS a viable solution, the burst-scheduling algorithms need to be able to utilize the available wavelengths efficiently, while being able to operate fast enough to keep up with the burst incoming rate. For example, for a 16-port OBS router with 64 wavelengths per link, each operating at 10 Gb/s, we need to process one burst request every 78 ns in order to support an average burst length of 100 kB. When implemented in hardware, the well-known horizon scheduler has O(1) runtime for a practical number of wavelengths. Unfortunately, horizon scheduling cannot utilize the voids created by previously scheduled bursts, resulting in low bandwidth utilization. To date, minimum starting void is the fastest scheduling algorithm that can schedule wavelengths efficiently. However, while its complexity is O(log m), it requires 10 log m memory accesses to schedule a single burst. This means that it can take up to several microseconds for each burst request, which is still too slow to make it a practical solution for OBS deployment. In this paper, we propose an optimal burst scheduler using constant time burst resequencing (CTBR), which has O(1) runtime. The proposed CTBR scheduler is able to produce optimal burst schedules while having processing speed comparable to the horizon scheduler. The algorithm is well suited to high- performance hardware implementation.
Inhibition of translation in living eukaryotic cells by an RNA G-quadruplex motif (2008)

Guanine-rich sequences can adopt intramolecular four-stranded structures, called G-quadruplexes. These motifs have been intensively investigated on the DNA level, but their overall biological relevance remains elusive. Only recently has research concerning the function of G-quadruplexes in RNAs commenced. Here, we demonstrate for the first time, that an RNA G-quadruplex structure inhibits translation in vivo in eukaryotic cells. We investigated the function of a highly conserved, thermodynamically stable RNA G-quadruplex in the 5'-UTR of the mRNA of the human Zic-1 zinc-finger protein. Using dual luciferase reporter assay, we demonstrate that the Zic-1 RNA G-quadruplex represses protein synthesis inside eukaryotic cells. Quantitative RT-PCR assays confirmed that the reduction of protein synthesis is due to regulation of the translation process and not a consequence of reduced transcription. Western blot analysis revealed that expression of Zic-1 is strongly reduced by a 73 nucleotides-long fragment of the UTR containing the G-quadruplex motif. These structures might add to the more recently discovered elements in untranslated regions of mRNAs that regulate their translation.
Design and Characterization of Novel Barium Strontium Titanate Thick Films for Sub-6 GHz RF Applications (2021)

In this article, a novel study of the design and characterization of barium strontium titanate (BST) thick films produced by electrophoretic deposition (EPD) on flexible platinum foils is reported. Intended for sub-6 GHz radio frequency (RF) applications, a study on film and electrode thickness is conducted. First, a comparison of tunability and quality factor between different film thicknesses regarding frequency is performed. The Ba <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.7</sub> Sr <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.3</sub> TiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> varactors demonstrate variable capacitance between 49% and 55% for frequencies from 500 MHz to 5 GHz. Afterward, the influence of electrode thickness on the capacitance and quality factor of the films are studied. The variable capacitance and the quality factor present a tradeoff regarding the parametric studies of film and electrode thicknesses. Lastly, a microstrip line is deposited over the BST thick film to simulate and measure the phase-shifting capabilities of the device. Using a one-tone measurement setup, the small-signal S-parameter measurements of the phase shifter are also presented, and the linearity is analyzed considering two different bias voltages, 0 and 10 V. For the first time, the BST thick films fabricated by EPD process are implemented and measured in the RF regime as a metal–insulator–metal capacitor and as a phase shifter circuit.
The effects of processing variables on electrospun poly(ethylene glycol) fibrous hydrogels formed from the thiol‐norbornene click reaction (2021)

Abstract Electrospinning has been used to create scaffolds with tunable micro/nano architecture, stiffness, and porosity to mimic native extracellular matrix. This study investigated the effects of electrospinning parameters and hydrogel formulation (solvent and crosslinker type) on the architecture and properties of fibrous poly(ethylene glycol) (PEG) hydrogels formed from a photoclick thiol‐norbornene reaction. Fibrous hydrogels were prepared using hydrogel precursors (four‐arm PEG norbornene and multi‐thiol crosslinker), sacrificial poly(ethylene oxide) (PEO, 400 kDa), and photoinitiator (I2959) in either 2,2‐triflouroethanol (TFE) or water. Three thiol crosslinkers‐ 2,2′‐(ethylenedioxy)diethanethiol (EDT), pentaerythritol tetrakis(3mercaptopropionate) (PTMP), and PEG dithiol (PEGDT)‐ were investigated. Fibrous PEG networks with uniform fibers were produced at applied voltages of 10 or 12 kV for TFE and 16 kV for water. Fiber diameters of electrospun hydrogels were largely affected by the solvent when combined with PEO concentration and ranged from 0.5 to 3.5 mm in dry state. While the effect of crosslinker type on fiber diameter, morphology, and porosity of the fibrous hydrogel was minimal, it did modulate its shear modulus. To this end, this study provides the groundwork for selecting processing parameters to achieve desired properties of fibrous PEG thiol‐norbornene hydrogels for intended tissue engineering applications ranging from neural, cardiovascular to musculoskeletal.
Avoiding Misannotation of In-Source Fragmentation Products as Cellular Metabolites in Liquid Chromatography–Mass Spectrometry-Based Metabolomics (2015)

Liquid chromatography-mass spectrometry (LC-MS) technology allows for rapid quantitation of cellular metabolites, with metabolites identified by mass spectrometry and chromatographic retention time. Recently, with the development of rapid scanning high-resolution high accuracy mass spectrometers and the desire for high throughput screening, minimal or no chromatographic separation has become increasingly popular. When analyzing complex cellular extracts, however, the lack of chromatographic separation could potentially result in misannotation of structurally related metabolites. Here, we show that, even using electrospray ionization, a soft ionization method, in-source fragmentation generates unwanted byproducts of identical mass to common metabolites. For example, nucleotide-triphosphates generate nucleotide-diphosphates, and hexose-phosphates generate triose-phosphates. We evaluated yeast intracellular metabolite extracts and found more than 20 cases of in-source fragments that mimic common metabolites. Accordingly, chromatographic separation is required for accurate quantitation of many common cellular metabolites.
Surgery-induced insulin resistance in human patients relations to glucoseutilization and transport (1999)

To investigate the underlying molecular mechanisms for surgery-induced insulin resistance in skeletal muscle, six otherwise healthy patients undergoing total hip replacement were studied before, du ...
Heart rate and heart rate variability in patients with chronic inflammatory joint disease: The role of pain duration and the insular cortex (2021)

Abstract Chronic inflammatory joint diseases (CIJD) have been linked to increased cardiovascular morbidity and mortality. A decisive reason could be a dysregulation of the autonomic nervous system (ANS), which is responsible for the control of cardio-vascular function. So far, the cause of changes in ANS functions remains elusive. In this study, we investigate the role of chronic pain and the insular cortex in autonomic control of cardiac functioning in patients with CIJD. We studied the sympathetic and parasympathetic branch of the ANS through the assessment of heart rate and heart rate variability (HRV) at rest and under cognitive stimulation. Furthermore, we investigated insular cortex volume by performing surface-based brain morphometry with FreeSurfer. For this study, 22 individual age- and sex-matched pairs for the magnetic resonance imaging analyses and 14 for the HRV analyses were recruited. Pain duration was negatively correlated with the resting heart rate in patients with chronic inflammatory joint diseases (n = 19). In a multiple linear regression model including only CIJD patients with HR at rest as a dependent variable, we found a significant positive relationship between HR at rest and the volume of the left insular cortex and a significant negative relationship between HR at rest and the volume of the right insular cortex. However, we found no significant differences in HRV parameters or insular cortex volumes between both groups. In this study we provide evidence to suggest insular cortex involvement in the process of ANS changes due to chronic pain in CIJD patients.
Specific Phospholipid Oxidation Products Inhibit Ligand Activation of Toll-Like Receptors 4 and 2 (2003)

These studies report a novel mechanism that involves alterations to lipid raft/caveolar processing, by which specific phospholipid oxidation products inhibit activation by TLR4 and TLR2 ligands. These studies have broader implications for the role of ox-PAPC as a regulator of specific lipid raft/caveolar function.
Syntheses of conformationally rigid catecholamine derivatives. (1977)

2-Amino-5, 6-dihydroxy-1, 2, 3, 4-tetrahydro-1-naphthalenol (1), 5, 6-dihydroxy-2-methylamino-1, 2, 3, 4-tetrahydro-1-naphthalenol (2) and 5, 6-dihydroxy-2-isopropylamino-1, 2, 3, 4-tetrahydro-1-naphthalenol (3), which are conformationally rigid derivatives of noradrenaline, adrenaline and isoproterenol respectively, were synthesized from 2-amino-5, 6-dimethoxy-3, 4-dihydro-1 (2H)-naphthalenone (15) prepared by several modifications of the known procedures. The reduction of 1-carbonyl group into hydroxy group at the final step of the syntheses showed unsatisfactory stereoselectivity affording mixtures of 1, 2-cis and 1, 2-trans derivatives. Each cis and trans isomer of 2 (2-cis and 2-trans) was obtained by a sequence of reactions employing 5, 6-dibenzyloxy materials via cis-and trans-2-(N-benzyl-N-methylamino)-5, 6-dibenzyloxy-1, 2, 3, 4-tetrahydro-1-naphthalenol (26-cis and 26-trans).
ChemInform Abstract: Palladium‐Catalyzed Cross‐Coupling and Related Processes: Some Interesting Observations that Have Been Exploited in Synthetic Chemistry. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Automated classification of mandibular cortical bone on dental panoramic radiographs for early detection of osteoporosis (2015)

Findings on dental panoramic radiographs (DPRs) have shown that mandibular cortical index (MCI) based on the morphology of mandibular inferior cortex was significantly correlated with osteoporosis. MCI on DPRs can be categorized into one of three groups and has the high potential for identifying patients with osteoporosis. However, most DPRs are used only for diagnosing dental conditions by dentists in their routine clinical work. Moreover, MCI is not generally quantified but assessed subjectively. In this study, we investigated a computer-aided diagnosis (CAD) system that automatically classifies mandibular cortical bone for detection of osteoporotic patients at early stage. First, an inferior border of mandibular bone was detected by use of an active contour method. Second, regions of interest including the cortical bone are extracted and analyzed for its thickness and roughness. Finally, support vector machine (SVM) differentiate cases into three MCI categories by features including the thickness and roughness. Ninety eight DPRs were used to evaluate our proposed scheme. The number of cases classified to Class I, II, and III by a dental radiologist are 56, 25 and 17 cases, respectively. Experimental result based on the leave-one-out cross-validation evaluation showed that the sensitivities for the classes I, II, and III were 94.6%, 57.7% and 94.1%, respectively. Distribution of the groups in the feature space indicates a possibility of MCI quantification by the proposed method. Therefore, our scheme has a potential in identifying osteoporotic patients at an early stage.