gebhart/patrepeval huggingface dataset:
Threshold Effect for Penetration of Prothrombin into Phospholipid Monolayers (1995)

Since the enzymatic conversion of prothrombin (II) into thrombin occurs at a membrane-solution interface, the mode of interaction of II with condensed monolayers containing phosphatidylserine (PS) was studied using two complementary methods of direct measurement at surfaces. The adsorption isotherms were determined by measuring surface radioactivity of bound tritiated proteins. Penetration of II through the monolayers could be detected using alternating-current polarography. The interactions of prothrombin with monolayers containing 25% PS, are more complex than those with 100% PS, since they are dependent on coverage. There is a threshold concentration, separating two distinct binding states, correlated with two distinct dissociation constants (Kd), both in the presence and in the absence of calcium. At low coverage, the adsorption process, mainly electrostatic, is consistent with a PS- dependent Kd. The higher affinity obtained at higher coverage is correlated with penetration of II into monolayer, by hydrophobic forces, since in this case the Kd is PS-independent.
L-Methionine inhibits growth of human pancreatic cancer cells (2013)

We have previously shown that L-methionine inhibits proliferation of breast, prostate, and colon cancer cells. This study extends these findings to BXPC-3 (mutated p53) and HPAC (wild-type p53) pancreatic cancer cells and explores the reversibility of these effects. Cells were exposed to L-methionine (5 mg/ml) for 7 days or for 3 days, followed by 4 days of culture without L-methionine (recovery). Cell proliferation, apoptosis, and cell cycle effects were assessed by flow cytometry after staining for Ki-67 or annexin V/propidium iodide. Cell proliferation was reduced by 31-35% after 7 days of methionine exposure; the effect persisted in BXPC-3 and HPAC cells after 4 days of recovery. Methionine increased apoptosis by 40-75% in HPAC cells, but not in BXPC-3 cells. Continuous exposure to methionine caused accumulation of BXPC-3 cells in the S phase and HPAC cells in both the G0/G1 and S phases; however, after 4 days of recovery, these effects disappeared. In conclusion, L-methionine inhibits proliferation and interferes with the cell cycle of BXPC-3 and HPAC pancreatic cancer cells; the effects on apoptosis remarkably persisted after methionine withdrawal. Apoptosis was induced only in BXPC-3 cells. Some of the differences in the effects of methionine between cell lines may be related to disparate p53 status. These findings warrant further studies on the potential therapeutic benefit of L-methionine against pancreatic cancer.
Pulmonary Hypertension Complicating Mixed Connective Tissue Disease (1998)

Mixed connective tissue disease (MCTD)has a combination of clinical features similar to those of systemic lupus
Epoxy resin based tissue substitutes (1977)

A series of epoxy resin based tissue substitutes, simulating adipose tissue, bone, breast, lung, muscle and skin is described. Details of the physical radiation characteristics of the formulated systems are given, together with the manufacturing procedures. The versatility of the range of substitutes is discussed in terms of both investigated and projected applications in experimental radiation studies.
MTL neurons phase-lock to human hippocampal theta (2022)

Abstract Memory formation depends on neural activity across a network of regions, including the hippocampus and broader medial temporal lobe (MTL). Interactions between these regions have been studied indirectly using functional MRI, but the bases for inter-regional communication at a cellular level remain poorly understood. Here we evaluate the hypothesis that oscillatory currents in the hippocampus synchronize the firing of neurons both within and outside the hippocampus. We recorded extracellular spikes from 1,854 single- and multi-units simultaneously with hippocampal local field potentials (LFPs) in 28 neurosurgical patients who completed virtual navigation experiments. A majority of hippocampal neurons phase-locked to oscillations in the slow (2-4Hz) or fast (6-10Hz) theta bands, with a significant subset exhibiting nested slow theta × beta frequency (13-20Hz) phase-locking. Outside of the hippocampus, phase-locking to hippocampal oscillations occurred only at theta frequencies and primarily among neurons in the entorhinal cortex and amygdala. Extrahippocampal neurons phase-locked to hippocampal theta even when theta did not appear locally. These results indicate that spike-time synchronization with hippocampal theta is a defining feature of neuronal activity in the hippocampus and structurally-connected MTL regions. Theta phase-locking could mediate flexible communication with the hippocampus to influence the content and quality of memories.
The aerodynamic design of high Mach number nozzles utilizing axisymmetric flow with application to a nozzle of square test section (1952)

A method 'is givenforthedesign of three-dimensional nozzles utilizing axisymmetric flow.Thenozzle canbe designed to produce Unifoti flowin a testchamber of arbitrary crosssection.Themethod, is applied to obtain thefinalcoordinates of a Machnumber 10 nozzle forwhicha square testsection is specified to reduce thepossibility of axisymmetric imperfections at thewallandto provide fortheinstallation of schlieren windows.Radial flowis usedin a pm?tion of theflawfield to reduce thecomputation time.Theremainder of theflowfieldis computed by themethod of characteristics, buta simplified method is usedneartheaxis.Tables whichfacilitate computation of theradial flowandtheflowneartheaxisare included.Transition streamlties determined fromtheanalytic expressions of KunoFoelsch arecompred withthestreamlines obtained fromthecharacteristics netof theMach number 10 nozzle.TheFoelsch streamlines deviate fromtheflow-net streamlines by as muchas 12 percent.Similar analytic expressions are derived fromthegeometric properties-of the flow.Thesenewexpressions result intransition streamlines witha maximum errorof aboutk percent..
Contrast variations in high-level multiplexed twisted nematic liquid-crystal displays (1986)

Investigations have revealed contrast variations in twisted nematic liquid-crystal matrix displays. These are consistent with effective changes in the applied torque due to relaxation of the permittivity at the frequencies at which significant power is applied in the Fourier spectrum of the stimulus waveform.
Characteristics of lead ion-stimulated phosphorylation of Electrophorus electricus electroplax (Na+ + K+)-adenosine triphosphatase and inhibition of ATP-ADP exchange. (1978)

Pb2+-stimulated phosphorylation of Electrophorus electricus electroplax (Na+ + K+)-adenosine triphosphatase is prevented by stoichiometric quantities of 2,3-dimercaptopropanol. The chelator in the same low concentrations does not block Na+-dependent phosphorylation. Both Pb2+-and Na+-dependent phosphorylation reactions show the same dependence on MgCl2. Phosphorylation in the presence of both Na+ and Pb2+ is cumulative suggesting that Pb2+ and Na+ bind at separate, independent sites. The enthalpy change due to binding of Pb2+ is about -1.76 kcal/mol. 32P-phosphopeptides obtained from pronase or pepsin digests of Pb2+-and Na+-dependent phosphoproteins are electrophoretically identical. Pb2+ does not stimulate but does inhibit ATP-ADP exchange activity under the conditions in which this activity is stimulated by Na+. Since the phosphorylation sites are identical, it is concluded that the differences in reactivity of the Na+- and Pb2+-phosphoenzymes are due to different conformational changes produced by binding of Na+ and Pb2+. The Pb2+-sensitive conformation is critical for Na+ specificity of phosphorylation, reversibility of phosphorylation, and for phosphatase activity but not for acceptor site phosphorylation by ATP. These findings have implications for enzyme reaction models.
Diode-Clamped Linear Amplifier using n-channel MOSFET and Crossover Distortion Compensation Method (2018)

This paper proposes a new diode-clamped linear amplifier (DCLA) topology using only n-channel MOSFETs. Although the conventional DCLA consists of n and p-channel MOSFETs, the proposed DCLA is composed of n-channel MOSFETs. Therefore, the proposed DCLA is easy to develop, because selection of complementary pair MOSFETs is not needed. As with the conventional DCLA, noise level of output voltage of the proposed DCLA is lower than general pulse width modulation (PWM) inverters, because the DCLA uses multilevel topology and active state of MOSFETs. Additionally, this paper also proposes a method of voltage feed-back control, which is capable of compensating crossover distortion of the DCLA. The output voltage of the DCLA has crossover distortion that causes the increase of voltage error and total harmonic distortion (THD). In order to compensate the crossover distortion, a voltage compensator including a plant model for the proposed DCLA is implemented. The proposed method reduces THD of output voltage by 90 percent through the simulations and experimental results.
The importance of inner-shell electronic structure for enhancing the EUV absorption of photoresist materials (2017)

In order to increase computation power and efficiency, the semiconductor industry continually strives to reduce the size of features written using lithographic techniques. The planned switch to a shorter wavelength extreme ultraviolet (EUV) source presents a challenge for the associated photoresists, which in their current manifestation show much poorer photoabsorption cross sections for the same dose. Here we consider the critical role that an inner-shell electronic structure might play in enhancing photoabsorption cross sections, which one can control by the choice of substituent elements in the photoresist. In order to increase the EUV sensitivity of current photoresists, it is critical to consider the inner-shell atomic structure of the elements that compose the materials. We validate this hypothesis using a series of halogenated organic molecules, which all have similar valence structures, but differ in the character of their semi-core and deep valence levels. Using various implementations of time-dependent density functional theory, the absorption cross sections are computed for the model systems of CH<sub>3</sub>X, X = H, OH, F, Cl, Br, I, as well as a representative polymer fragment: 2-methyl-phenol and its halogenated analogues. Iodine has a particularly high cross section in the EUV range, which is due to delayed absorption by its 4d electrons. The computational results are compared to standard database values and experimental data when available. Generally we find that the states that dominate the EUV oscillator strength are generated by excitations of deep valence or semi-core electrons, which are primarily atomic-like and relatively insensitive to the specific molecular structure.
Performance evaluation of V2I-based channel aware floating car data transmission via LTE (2012)

The collection of Floating Car Data (FCD) is very important for dynamic traffic forecasts. For this purpose, sensor notes in cars are supposed to transmit traffic information via Long Term Evolution (LTE). In this paper, we evaluate this data transmission with regard to several Key Performance Indicators (KPIs) for a channel aware transmission. These indicators are the negative impact on human communication, the power consumption of the mobile devices and the local distribution of cars sending FCD in the scenario. As methodology for performance evaluation a close-to-reality parameterized Markovian model, laboratory data rate as well as power consumption measurements and ray tracing simulations are used. By applying channel aware transmission the Quality of Service (QoS) level of human communication can be obtained and simultaneously the power consumption is significantly reduced. In addition, the fraction of active FCD devices on the highway can be increased.
Examining Agreement and Longitudinal Stability Among Traditional and RTI-Based Definitions of Reading Disability Using the Affected-Status Agreement Statistic (2011)

Rates of agreement among alternative definitions of reading disability and their 1- and 2-year stabilities were examined using a new measure of agreement, the affected-status agreement statistic. Participants were 288,114 first through third grade students. Reading measures were Dynamic Indicators of Basic Early Literacy Skills Oral Reading Fluency and Nonsense Word Fluency, and six levels of severity of poor reading were examined (25th, 20th, 15th, 10th, 5th, and 3rd percentile ranks). Four definitions were compared, including traditional unexpected low achievement and three response-to-intervention-based definitions: low achievement, low growth, and dual discrepancy. Rates of agreement were variable but only poor to moderate overall, with poorest agreement between unexpected low achievement and the other definitions. Longitudinal stability was poor, with poorest stability for the low growth definition. Implications for research and practice are discussed.
Plant Anticancer Agents. XXII. Isolation of a Phorbol Diester and Its Δ5,6-7β-Hydroperoxide Derivative From Ostodes paniculata (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPlant Anticancer Agents. XXII. Isolation of a Phorbol Diester and Its Δ5,6-7β-Hydroperoxide Derivative From Ostodes paniculataSukhdev S. Handa, A. Douglas Kinghorn, Geoffrey A. Cordell, and Norman R. FarnsworthCite this: J. Nat. Prod. 1983, 46, 1, 123–126Publication Date (Print):January 1, 1983Publication History Published online1 July 2004Published inissue 1 January 1983https://pubs.acs.org/doi/10.1021/np50025a013https://doi.org/10.1021/np50025a013research-articleACS PublicationsRequest reuse permissionsArticle Views221Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Normalizing glycosphingolipids restores function in CD4+ T cells from lupus patients (2014)

Patients with the autoimmune rheumatic disease systemic lupus erythematosus (SLE) have multiple defects in lymphocyte signaling and function that contribute to disease pathogenesis. Such defects could be attributed to alterations in metabolic processes, including abnormal control of lipid biosynthesis pathways. Here, we reveal that CD4+ T cells from SLE patients displayed an altered profile of lipid raft-associated glycosphingolipids (GSLs) compared with that of healthy controls. In particular, lactosylceramide, globotriaosylceramide (Gb3), and monosialotetrahexosylganglioside (GM1) levels were markedly increased. Elevated GSLs in SLE patients were associated with increased expression of liver X receptor β (LXRβ), a nuclear receptor that controls cellular lipid metabolism and trafficking and influences acquired immune responses. Stimulation of CD4+ T cells isolated from healthy donors with synthetic and endogenous LXR agonists promoted GSL expression, which was blocked by an LXR antagonist. Increased GSL expression in CD4+ T cells was associated with intracellular accumulation and accelerated trafficking of GSL, reminiscent of cells from patients with glycolipid storage diseases. Inhibition of GSL biosynthesis in vitro with a clinically approved inhibitor (N-butyldeoxynojirimycin) normalized GSL metabolism, corrected CD4+ T cell signaling and functional defects, and decreased anti-dsDNA antibody production by autologous B cells in SLE patients. Our data demonstrate that lipid metabolism defects contribute to SLE pathogenesis and suggest that targeting GSL biosynthesis restores T cell function in SLE.
A New Sputtering Source for Magnetic Film Preparation (1992)

A new sputtering source has been proposed, especially aiming to fabricate a Co-Cr composite medium for perpendicular magnetic recording. The source consists of facing side walls and a bottom plate of a source magnetic material. The wall targets work as a part of a magnetic circuit for getting a strong enough magnetic field. Targets of permalloy and Co-Cr were constructed for a test. A well confined plasma makes discharge characteristics of low discharge voltages very stable even at low argon gas pressures. Wide film thickness homogeneity was obtained due to the collimated atoms sputtered from the gun structure type target. Recovery factor of sputtered materials to the substrate was 10 times or more than those of conventional sources. The deposited permalloy films show low coercivities with high crystal orientations even at a high input power. These imply that the new sputtering source is one of promising means for fabricating Co-Cr composite media with a high throughput.
Thiophosphorylation of Biologically Relevant Alcohols by the Oxathiaphospholane Approach (2002)

2-Alkoxy-2-thiono-1,3,2-oxathiaphospholanes are readily transformed into phosphorothioate monoesters of the corresponding alcohols in a one-pot process, involving the reaction with 3-hydroxypropionitrile in the presence of DBU, followed by treatment with aqueous ammonia. In this way a series of nucleoside-3′-O- and 5′-O-phosphorothioates were prepared, as well as phosphorothioate derivatives of selected polyols.
The Effect of Microbial Growth on Feed Stability and Delivery in a Denitrifying Fixed Bed Reactor Designed for Space Flight to Recycle Graywater (2002)

&lt;div class="htmlview paragraph"&gt;Ground studies at Kennedy Space Center were done to define and optimize performance of the Immobilized Microbe Microgravity Water Processing System (IMMWPS), a denitrifying, fixed-bed reactor designed for Shuttle flight-testing. The purpose of the current studies was to evaluate additional flight protocol issues, including microbial backgrowth in the influent tubing and concomitant reduction of influent Igepon levels prior to bioreactor treatment, and the effects of bioreactor shutdown for loading and launch. Experiments were done to evaluate sterilization procedures and the effect of delivery tubing diameter on microbial backgrowth. Analytical methods employed included ion-pairing reversed phase chromatography coupled with suppressed conductivity detection for monitoring Igepon concentrations in the influent and effluent, and acridine orange direct count (AODC) technique for quantifying microbial growth in influent lines.&lt;/div&gt;
Amino Acid Incorporation into Liver Proteins during Extrahepatic Cholestasis in the Rat (1974)

Extrahepatic cholestasis was induced in rats by ligation of the bile duct. L-(4,5-3H)-leucine or L-(U-14C)-leucine were incorporated into the proteins of control and cholestatic liver slices by incubation in balanced salt media. The cholestatic liver showed a rate of amino acid incorporation which was approximately three times that of control liver. There was no apparent effect on the specific radioactivity of the precursor. The distribution of protein-bound radioactivity among sub-cellular fractions was studied. The radioactivity increased in all the main fractions, and the largest increase was seen in the soluble proteins. Serum from control or cholestatic animals and bile from control animals added during incubation of liver slices had small effect on the incorporation of leucine. Leucine incorporation was not appreciably altered in other organs.
Preliminary observations on reproduction in a female sheep-goat chimaera (1991)

Four oestrous cycles of a female sheep-goat chimaera were monitored by using a vasectomised ram. The mean (+/- se) length of the cycle was 18.5 +/- 0.64 days with a range from 17 to 20 days. The chimaera was superovulated twice, bred to fertile rams, and the embryos recovered by laparotomy 13 or five days after oestrus, so that karyotype analysis could reveal the genotype of the oocyte. After the first superovulation one ovine day-13 embryo was collected; two fragments of another embryo (or embryos) were also collected, but readable chromosome spreads were not obtained from these embryos or from the two four-cell embryos that were collected five days after the second superovulation. Two surgical embryo transfers to the chimaera resulted in pregnancies. The first transfer involved an eight-cell ovine embryo and two caprine morulae and ended in the abortion of an ovine fetus between days 110 and 130. The second pregnancy occurred after the transfer of two ovine and two caprine morulae. A healthy lamb was born on day 147 of pregnancy. Both placentae had small numbers of cotyledons. A histological evaluation of the cotyledons revealed an abnormal placentome structure in the first pregnancy but not in the second.
Coercivity analysis in sputtered Sm–Co thin films (1999)

Hard nanocrystalline Sm–Co thin films having a thickness of 500 nm have been prepared by heat-treating magnetron sputtered amorphous samples deposited over a 300 nm Cr buffer layer onto room temperature water cooled Si substrates. The thermal treatments resulted in the nanocrystallization of the precursor films and in the development of room temperature coercivities covering a range going from a few kOe, measured in the samples treated at low temperature, up to some tens of kOe, observed in the case of the films annealed at high temperatures (the room temperature coercivity of the sample treated at 825 K was 26 kOe). Our analysis of the influence of the thermal treatments on the particularities of the reversal process was based on the measurement of the temperature dependence of the coercive force. It was carried out in the framework of the micromagnetic model, which allowed us to evaluate two parameters accounting for the local anisotropy reduction and the magnitude of the local dipolar fields, respectively. Our results show that the high temperature treatments result in a better degree of crystallization (lower local anisotropy deterioration). That crystallinity improvement is associated to an increase of the local dipolar interactions.