gebhart/patrepeval huggingface dataset:
Linkage studies of bipolar disorder in the region of the Darier's disease gene on chromosome 12q23‐24.1 (1995)

We have recently described a family in which there is cosegregation of major affective disorder with Darier's disease and have mapped this autosomal dominant skin disorder to 12q23-q24.1. This has provided an interesting candidate region for genetic studies of bipolar disorder. We have studied the segregation of seven markers spanning the Darier's disease locus in 45 bipolar disorder pedigrees and found modest evidence in support of linkage under heterogeneity for 5 of these markers. Nonparametric analyses were suggestive of linkage with a marker at the gene encoding a secretory form of phospholipase A2. Our sample has relatively low power to detect linkage under heterogeneity and independent researchers should examine markers from this region in further samples of bipolar pedigrees.
Albuminuria According to Status of Autoimmunity and Insulin Sensitivity Among Youth With Type 1 and Type 2 Diabetes (2013)

In youth with diabetes, the DAA(-)/IR group had a greater UACR than all other groups, possibly because of the greater magnitude of insulin resistance. Further exploration of the relationships between severity of insulin resistance, autoimmunity, and albuminuria in youth with diabetes is warranted.
THE IMMACULATE CONCEPTION AND CALDERÓN'S LA HIDALGA DEL VALLE (1983)

THE IMMACULATE CONCEPTION AND CALDERÓN'S LA HIDALGA DEL VALLE Get access ELIZABETH TERESA HOWE ELIZABETH TERESA HOWE Tufts University Search for other works by this author on: Oxford Academic Google Scholar Forum for Modern Language Studies, Volume XIX, Issue 1, January 1983, Pages 75–84, https://doi.org/10.1093/fmls/XIX.1.75 Published: 01 January 1983
Surface diffusion during shadow-mask-assisted molecular-beam epitaxy of III-V compounds (2005)

We present a comprehensive discussion of molecular-beam epitaxy of III-V compound semiconductors through shadow masks. Based on model calculations and growth experiments, we examine how the surface diffusion and the incorporation of group-III adatoms depend on the growth configuration, group-III and group-V fluxes, and the crystal orientation. According to a macroscopic diffusion model, gradients of the group-V flux drive the unidirectional migration of group-III adatoms. Although this effect is generally observed in the experiments, the different growth profiles obtained for [11¯0]- and [110]-oriented samples reflect the different roles of A-type and B-type steps in the incorporation of group-III adatoms. We also demonstrate that during the heteroepitaxial growth of InAs, the dissociation of the GaAs substrate is locally enhanced by the incidence of the In beam. This effect can be exploited for shadow-mask-assisted etching on selected areas. In addition, we show how the positions and sizes of III-V nanostructures can be controlled with high precision on a planar substrate by the usage of shadow masks with multiple nanoscale apertures.
PC-MSDM: A quality metric for 3D point clouds (2019)

In this paper, we present PC-MSDM, an objective metric for visual quality assessment of 3D point clouds. This full-reference metric is based on local curvature statistics and can be viewed as an extension for point clouds of the MSDM metric suited for 3D meshes. We evaluate its performance on an open subjective dataset of point clouds compressed by octree pruning; results show that the proposed metric outperforms its counterparts in terms of correlation with mean opinion scores.
Clonidine twice daily in hypertension. Effects of two dosage regimens on blood pressure, side-effects and plasma clonidine concentrations. (1983)

The effects of two b.i.d. dosing schedules of clonidine on blood pressure, side-effects and plasma concentration of clonidine were studied in a randomized cross-over study. The blood pressures of 10 hypertensive inpatients on diuretic treatment were recorded every 3-4 hours throughout the study. A twice-daily regimen with 0.075 mg clonidine administered at 8 a.m. and 0.15 mg at 10 p.m. resulted in a wider fluctuation of blood pressure than the same doses given at 8 a.m. and 4 p.m. The most conspicuous finding was the significant rise (p less than 0.001) of diastolic blood pressure at 8 p.m., when clonidine was given at 8 a.m. and 10 p.m. The overall mean values of supine systolic and diastolic blood pressures were normotensive and did not differ from each other in the two dosing schedules. There were no obvious differences in subjective side-effects between the two regimens. Predose clonidine concentrations varied interindividually between 0.15 and 1.12 ng/ml, but the fluctuation in one and the same subject was small and related to dose and its timing. Thus, twice-daily dosing of clonidine seems to result in a satisfactory blood pressure reduction. Fluctuation of blood pressure is greater when the evening dose is given at 10 p.m.
Advanced signaling strategies for the Hybrid MIMO Phased-Array Radar (2010)

The Hybrid MIMO Phased Array Radar, or HMPAR, is a notional concept for a multisensor radar architecture that combines elements of traditional phased-array radar with the emerging technology of Multiple-Input Multiple Output (MIMO) radar. A HMPAR comprises a large number, MP, of T/R elements, organized into M subarrays of P elements each. Within each subarray, passive elementlevel phase shifting is used to steer transmit and receive beams in some desired fashion. Each of the M subarrays are in turn driven by independently amplified phase-coded signals. This paper proposes new transmit signal selection strategies based on the observation that some MIMO signal sets, such as those proposed by us previously, cause a very rapid sequential or raster scan across some field of view. Exploiting this property allows one to create and process multiple beams simultaneously. Furthermore, there exists a range-angle coupling in the transmit and receive signals that may lead to high-resolution target localization.
Theoretical and practical considerations in forming solid fuel layers inside vacuum insulated inertial confinement fusion targets (1979)

Vacuum layer ICF targets can be manufactured in such a way that a uniform cryogenic solid layer may be formed within the fuel container. By using either condensable gases or a mixture of He and a condensable gas as the exchange gas, the final mass density within the vacuum layer may be specified by the designer. To evaluate the potential uniformity of a solid cryogenic fuel layer within a specific design the time to condense and freeze the fuel must be calculated. A general model is offered to calculate this information and it is shown that for the case of He and H/sub 2/ exchange gases in the continuum regime of cooling the fuel layer uniformity should be as good as current experimental results with simple targets. Further extension of this model to include other exchange gases and encompass the transition and free molecule regimes of cooling will allow evaluation of a broader range of these vacuum layer targets.
Hemmung von Cyclin B1 inhibiert die Proliferation von Brustkrebszellen (2005)

Fragestellung: Die Zahl der Brustkrebserkrankungen nimmt jedes Jahr weiter zu. Obwohl es zu Verbesserungen in der Frühdiagnose, den Operationstechniken, der adjuvanten Hormontherapie und der Chemotherapie gekommen ist, bleibt Brustkrebs eine der Hauptgründe für die Sterblichkeitsrate bei den Krebserkrankungen. Das wachsende Wissen um die molekularen Signalwege bei der Brustkrebsentstehung hat mehr und mehr Auswirkungen auf Diagnose und Therapie. Neben den bestuntersuchten Brustkrebsgenen wie BRCA1, BRCA2, HER2 und p53, zeigen immer mehr Studien, dass eine unkontrollierte Überexpression von Cyclin B1, der regulatorischen Untereinheit des Mitose-Phase Förderfaktors eng mit der Transformation von Brustkrebszellen verbunden ist. Somit könnte die Hemmung von Cyclin B1 eine attraktive Form der Brustkrebstherapie darstellen.
New design for a time-of-flight mass spectrometer with a liquid beam laser desorption ion source for the analysis of biomolecules (2004)

We describe a novel liquid beam mass spectrometer, based on a recently discovered nanosecond laser desorption phenomenon, [W. Kleinekofort, J. Avdiev, and B. Brutschy, Int. J. Mass Ion. Processes 152, 135 (1996)] which allows the liquid-to-vacuum transfer, and subsequent mass analysis of pre-existing ions and ionic associates from liquid microjets of aqueous solutions. The goal of our novel technical approach is to establish a system with good mass resolution that implements improvements on critical components that make the system more reliable and easier to operate. For laser desorption pulsed dye-laser difference frequency mixing is used that provides tunable infrared light near the absorption maximum of liquid water around 3 μm. Different types of liquid beam glass nozzles (convergent capillary and aperture plate nozzles) are investigated and characterized. Starting from theoretical considerations of hydrodynamic drag forces on micrometer size droplets in supersonic rarefied gas flows we succeeded in capturing efficiently the liquid beam in a liquid beam recycling trap operating at the vapor pressure of liquid water. For improving the pollution resistance, the liquid jet high vacuum ion source region is spatially separated from the reflectron time-of-flight mass spectrometer (TOF–MS) working behind a gate valve in an ultrahigh vacuum environment. A simple (simulation optimized) ion optics is employed for the ion transfer from the source to the high vacuum region. This new feature is also mostly responsible for the improved mass resolution. With the present tandem-TOF–MS setup a resolution of m/Δm≈1800 for the low and m/Δm≈700 in the high mass region has been obtained for several biomolecules of different mass and complexity (amino acids, insulin, and cytochrome c).
Genetic architecture of smoking: Evaluating rare variant contribution from deep whole-genome sequencing of up to 26,000 individuals (2021)

Abstract Background Across complex traits, common variants explain only a modest amount of variance, with SNP-heritability consistently below heritability estimates from close relatives. Here, we examined the contribution of rare variant to tobacco use risk in up to 26,000 individuals of European ancestry in the Trans-Omics for Precision Medicine (TOPMed) program with whole genome sequence (WGS;~30X coverage). Method We grouped about 35 million genetic variants by their minor allele frequencies (MAF) and linkage disequilibrium (LD) and estimated SNP-heritability for age of smoking initiation (N = 14,747), cigarettes smoked per day (N = 15,425), smoking cessation (N = 17,871) and initiation (N = 26,340) using linear mixed model. Rare variant population structure is detected and adjusted for by permutation procedure. We estimated an upper bound for narrow-sense heritability for tobacco use using available pedigrees consisting of close relatives in TOPMed. Results Rare variants with MAF 0.1–0.01%, mostly from non-protein altering region, accounted for 26% of variation in age of initiation and 15% for cessation. Follow-up analysis indicated that about one-third of these rare variants contribtion is potentially confounded with rare variants structure even after adjusting for principal components. After further conservative adjustment of population structure, we estimated SNP-based heritability to be 0.21 (SE = 0.08) for age of initiation, 0.15 (0.06) for cigarettes per day, 0.21 (0.09) for cessation, and 0.24 (0.07) for initiation, 1.8–4.5 times higher than previous SNP-based estimates. Our pedigree-based upper-bound for SNP-based heritability ranged from 0.18–0.35. Conclusion The substantial contribution of rare variants for several smoking phenotypes sheds light on the missing heritability and genetic etiology of tobacco use. It also informs fine-mapping strategies since the majority of the rare variant contribution was located in non-coding regulatory regions.
A Non-Aqueous Lyotropic Liquid Crystal with a Starburst Dendrimer as a Solvent (1988)

Abstract A lamellar liquid crystal was formed by octanoic acid and a starburst polyethyleneimine dendrimer of the third generation: The minimum acid content corresponded to an acid/dendrimer molecular ratio of 13, e.g. approximately one acid per amino group. Infrared spectroscopy showed the acid molecules ionized. The maximum number of acids was approximately 2.5 per amino group and now the infrared spectra showed approximately one half of the carboxylic groups to be ionized.
Compact labeling schemes for ancestor queries (2001)

We consider the following problem. Give a rooted tree T, label the nodes of T in the most compact way such that given the labels of two nodes one can determine in constant time, by looking only at the labels, if one node is an ancestor of the other. The best known labeling scheme is rather straightforward and uses labels of size at most 2 log n, where n is the number of vertices In the tree. Our main result in this paper is a labeling scheme with maximum label size close to 3/2 log n.Our motivation for studying this problem is enhancing the performance of Web search engines. In the context of this application each indexed document is a tree and the labels of all trees are maintained in main memory. Therefore even small improvements in the maximum label size are important.There are no lower bounds known for this problem except for an obvious lower bound of log n that follows from the fact that different vertices must have different labels. The question whether one can find even shorter labels remains an intriguing open question.
Study of the A-ring conformation in 4,4-dimethyl-3-keto steroids (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudy of the A-ring conformation in 4,4-dimethyl-3-keto steroidsDennis A. Dougherty, Kurt Mislow, John W. Huffman, and John JacobusCite this: J. Org. Chem. 1979, 44, 10, 1585–1589Publication Date (Print):May 1, 1979Publication History Published online1 May 2002Published inissue 1 May 1979https://pubs.acs.org/doi/10.1021/jo01324a001https://doi.org/10.1021/jo01324a001research-articleACS PublicationsRequest reuse permissionsArticle Views109Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
S-limit shadowing implies the denseness of chain components with the shadowing property (2023)

For any continuous self-map of a compact metric space, we consider the space of chain components and prove that the s-limit shadowing implies the denseness of chain components with the shadowing property. It gives a partial answer to a question raised by Moothathu [Topology Appl. 158 (2011) 2232--2239]. We also prove that the s-limit shadowing is not generic in the space of homeomorphisms of a closed differentiable manifold.
Targeted toxins and saponins – a powerful cooperation (2010)

Saponins from Gypsophila species are known to enhance the cytotoxicity of targeted toxins. In general targeted toxins consist of two components: a toxin moiety with enzymatic activity and a ligand moiety, which mediates specific binding to cancer cells. It was shown that saponins from Gypsophila paniculata L. enhanced the toxicity of a targeted toxin, composed of the N-glycosidase saporin from Saponaria officinalis L. and human epidermal growth factor up to 2,500 000-fold in primary breast cancer cells. Meanwhile the efficiency of the combined application of saponins and targeted toxins was shown in a mouse tumour model. Compared to the single application of the targeted toxin (SA2E), the combination with saponins lead to a tremendous reduction (at least 50-fold) of the SA2E dosage. By this dose reduction side effects were only moderate. This represents an enormous step forward in the targeted anti tumour therapy with recombinant fusion toxins. However, in all these studies a mixture of saponins was used. For the further successful development of a combinatorial anti cancer therapy with targeted toxins and saponins pure saponins are mandatory. This study was intended to isolate pure saponins from Gypsophila paniculata L. in order to scruntinize the toxicity enhancing properties of isolated Gypsophila saponins on targeted toxins. One of the four isolated saponins showed strong, one moderate and two no cytotoxicity enhancing properties. On the basis of these results we determined the structural prerequisites for the saponin-mediated toxicity enhancement of targeted toxins.
High-speed optical time-division demultiplexer using semiconductor optical amplifiers (1992)

A nonlinear model for the dynamic operation of semiconductor optical amplifiers was developed using computer simulation techniques. The model is used to investigate the performance of a semiconductor optical amplifier serving as an optical gate for a high-speed optical time division demultiplexer. The performance of the amplifier as an optical gate is also shown as a function of the input optical signal levels, frequency and amplitude of the sinusoidal driving signal, and the precise time delay between the input optical signal and the driving electrical signal. The simulation results indicate that maximum demultiplexing speed can be increased from the 6-Gb/s maximum speed achievable using a single amplifier gate, to 10-12 Gb/s by using an optical gate consisting of two cascaded amplifiers.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Better Word Representations with Recursive Neural Networks for Morphology (2013)

Vector-space word representations have been very successful in recent years at improving performance across a variety of NLP tasks. However, common to most existing work, words are regarded as independent entities without any explicit relationship among morphologically related words being modeled. As a result, rare and complex words are often poorly estimated, and all unknown words are represented in a rather crude way using only one or a few vectors. This paper addresses this shortcoming by proposing a novel model that is capable of building representations for morphologically complex words from their morphemes. We combine recursive neural networks (RNNs), where each morpheme is a basic unit, with neural language models (NLMs) to consider contextual information in learning morphologicallyaware word representations. Our learned models outperform existing word representations by a good margin on word similarity tasks across many datasets, including a new dataset we introduce focused on rare words to complement existing ones in an interesting way.
A programmable microvalve-based microfluidic array for characterization of neurotoxin-induced responses of individual C. elegans (2009)

The soil dwelling nematode Caenorhabditis elegans (C. elegans) is an excellent model organism for the study of numerous disease including neurodegenerative disease. In this study, a programmable microvalve-based microfluidic array for real-time and long-term monitoring of the neurotoxin-induced responses of the individual C. elegans was developed. The device consisted of a flow layer and a control layer, which were used for worm manipulation. By activating the programmable microvalves in the control layer, mutiple worms could be individually captured and intermittently immobilized in parallel channels. Thus the mobility behavior, together with the corresponding dopaminergic neuron features of the worms in response to neurotoxin, could be investigated simultaneously. It was found that the neurotoxin MPP+ enabled to induce mobility defects and dopaminergic neurons loss in worms. The established system is easy and fast to operate, which offers not only the controllable microenvironment for analyzing the individual worms in parallel, monitoring the same worm over time, but also the capability to characterize the mobility behavior and neuron features in response to stimuli simultaneously. In addition, the device enabled to sustain the worm culture over most of their adult lifespan without any harm to worm, providing a potential platform for lifespan and aging research.
Transmembrane TNF Is Sufficient to Initiate Cell Migration and Granuloma Formation and Provide Acute, but Not Long-Term, Control of Mycobacterium tuberculosis Infection (2005)

TNF is critical for immunity against Mycobacterium tuberculosis infection; however, the relative contributions of the soluble and transmembrane forms of TNF in this immunity are unknown. Using memTNF mice, which express only the transmembrane form of TNF, we have addressed this question. Wild-type (WT), TNF-/-, and transmembrane TNF (memTNF) mice were infected with M. tuberculosis by aerosol. TNF-/- mice developed overwhelming infection with extensive pulmonary necrosis and died after only 33 days. memTNF mice, like WT mice, contained bacterial growth for over 16 wk, developed an Ag-specific T cell response, and initially displayed compact granulomas, comprised of both lymphocytes and macrophages. Expression of mRNA for the chemokines CXCL10, CCL3, CCL5, and CCL7 was comparable in both WT and memTNF mice. As the infection progressed, however, the pulmonary lesions in memTNF mice became larger and more diffuse, with increased neutrophil accumulation and necrosis. This was accompanied by increased influx of activated memory T cells into the lungs of memTNF mice. Eventually, these mice succumbed to infection with a mean time to death of 170 days. The expression of memTNF on T cells is functionally important because the transfer of T cells from memTNF, but not TNF-/- mice, into either RAG-/- or TNF-/- mice conferred the same survival advantage on the M. tuberculosis-infected recipient mice, as the transfer of WT T cells. Therefore, memTNF, in the absence of soluble TNF, is sufficient to control acute, but not chronic, M. tuberculosis infection, in part through its expression on T cells.
Improvement of drain leakage current characteristics in metal-oxide-semiconductor-field-effect-transistor by asymmetric source-drain structure (2012)

This paper is on the comparison of drain leakage current in asymmetric source-drain (ASD) MOSFET using only lightly doped drain (LDD) on drain side versus symmetric source-drain (SSD) MOSFET using LDD and deep diffusion doping on drain side. We used long-channel devices so as to avoid any leakage associated with short-channel effects. Therefore, junction leakage and gate-induced-drain-leakage (GIDL) current are only considered. The band-to-band tunneling model is used to fit the measured drain leakage currents. Measurement results show that the drain leakage current is less in ASD MOSFET. For the ASD MOSFET, junction leakage current is dominant. For the SSD MOSFET, junction leakage current is still dominant in the low drain-to-gate voltage region. However, GIDL current is dominant in the high drain-to-gate voltage region. The GIDL current is more sensitive for interface trap generated by hot-carrier injection than junction leakage current. The plotting curves of band-to-band tunneling are more different in SSD MOSFET than ASD MOSFET. Thus, ASD MOSFET is superior in leakage-side.
Lack of CpG Island Methylator Phenotype Defines a Clinical Subtype of T-Cell Acute Lymphoblastic Leukemia Associated With Good Prognosis (2005)

Our results suggest that the methylation profile may be a potential new biomarker of risk prediction in T-ALL.