gebhart/patrepeval huggingface dataset:
Histological assessment of new bone formation with biomimetic scaffold in posterolateral lumbar spine fusion. (2021)

Spinal fusion procedures often require the use of bone grafts (autograft or allograft) to help bone healing and to increase stability. However, the application of autografts is frequently limited by donor site morbidity. In recent years, different synthetic bone substitutes have been introduced in the clinical practice to overcome these limitations. The purpose of this paper is to report a case where a biomimetic, synthetic and osteoconductive bone graft substitute was successfully implanted in a patient during lumbar spine arthrodesis. The case of a 58-year-old female subjected to lumbar spine arthrodesis with bone augmentation is described. The bone graft substitute RegenOss® (Finceramica, Faenza, Italy) was implanted during spinal arthrodesis. The successful bone integration was evaluated by X-rays. After 11 months, the patient underwent a second surgery due to spine imbalance; the debris of the bone graft was therefore collected and analyzed by macroscopic evaluation and by histology. The bone substitute was successfully implanted during a spinal arthrodesis procedure. Histologic evaluation of the removed bone graft debris showed the complete resorption of the implant and the formation of new bone, which was well integrated with the host bone. This bone substitute may represent a safe and effective alternative to autologous bone grafts, avoiding adverse events related to donor-site morbidity.
Quest for the lost andromedin (2019)

Searchable abstracts of presentations at key conferences in oncology ISSN 2631-4657 (online)
Wider Use of Expedited Partner Therapy Might Benefit Women with Gonorrhea or Chlamydia (2015)

Expedited partner therapy (EPT), in which a patient with an identified sexually transmitted infection is given a prescription or medication for his or
Incorporating linguistic theories of pronunciation variation into speech–recognition models (2000)

This paper describes the use of distinctive linguistic features to represent acoustic variability of words for speech recognition. Focusing on conventional hidden Markov model technology, we review implicit use of linguistic features as questions in decision-tree design for both coarticulation and pronunciation modelling and describe possibilities for more explicit use. The importance of conditioning on (hierarchical) syllable and prosodic structure is discussed, and the problem of modelling relative timing of feature-dependent acoustic cues is raised as a key limitation of current models.
Efficacy of Xanomeline in Alzheimer Disease: Cognitive Improvement Measured Using the Computerized Neuropsychological Test Battery (CNTB) (1998)

The cognitive efficacy of the M1-selective muscarinic agonist xanomeline in mild-to-moderate Alzheimer disease (AD) was measured using the Computerized Neuropsychological Test Battery (CNTB) and the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-cog) in this 17-center, double-blind, placebo-controlled study. Three hundred forty-three patients were randomly assigned to receive 25, 50, or 75 mg xanomeline tartrate or placebo three times daily (t.i.d.) for 24 weeks, followed by placebo for 4 weeks in a single-blind washout phase. Cognitive function was assessed at randomization and after 4, 8, 12, 24, and 28 weeks. Three hundred nineteen patients were included in an intent-to-treat (ITT) analysis; 209 completers had evaluable data at week 24. ITT analysis showed a significant (p < or = 0.05) dose-response trend and a significant (p < or = 0.05) between-group comparison favoring 75 mg t.i.d. over placebo for the CNTB summary score but not for the ADAS-cog. In the completer analysis, however, the ADAS-cog showed a significant (p < or = 0.05) dose-response trend and between-group comparison, whereas the CNTB Summary Score did not. The ADAS-cog was less sensitive to treatment effects in mildly impaired patients (ADAS-cog < 21) than in moderately impaired patients (ADAS-cog > or = 21), whereas the CNTB was sensitive in the entire study population (mean ADAS-cog = 22.5+/-9.6). Significant (p < or = 0.05) beneficial treatment effects were seen in measures of simple reaction time and delayed verbal recall, which are included in the CNTB but not in the ADAS-cog. During the single-blind placebo washout period, the ADAS-cog score of the placebo group worsened dramatically (change of 2.63 points; p < or = 0.001), whereas the CNTB score remained stable (change of 1.04 points; p=0.694). Thus, the CNTB appears to be more objective than the ADAS-cog.
C-reactive protein predicts carotid atherosclerosis progression in mild to moderate risk and middle-aged patients. (2006)

C-reactive protein can predict the progression of early carotid atherosclerosis in patients with mild to moderate cardiovascular risk and/or middle-aged patients.
Cells for tissue engineering of cardiac valves (2015)

Heart valve tissue engineering is a promising alternative to prostheses for the replacement of diseased or damaged heart valves, because tissue-engineered valves have the ability to remodel, regenerate and grow. To engineer heart valves, cells are harvested, seeded onto or into a three-dimensional (3D) matrix platform to generate a tissue-engineered construct in vitro, and then implanted into a patient's body. Successful engineering of heart valves requires a thorough understanding of the different types of cells that can be used to obtain the essential phenotypes that are expressed in native heart valves. This article reviews different cell types that have been used in heart valve engineering, cell sources for harvesting, phenotypic expression in constructs and suitability in heart valve tissue engineering. Natural and synthetic biomaterials that have been applied as scaffold systems or cell-delivery platforms are discussed with each cell type. Copyright © 2015 John Wiley & Sons, Ltd.
A Simple Lower Bound on the Linearized Performance of Practical Symbol Synchronizers (1983)

In this paper we present a lower bound on the linearized mean-square timing error resulting from a practical synchronizer estimating the delay of a baseband PAM waveform which is corrupted by stationary Gaussian noise. This lower bound is easily evaluated, and applies to a broad class of synchronizers.
Transfusions with Hemoglobin Prepared by Crystallization, (1976)

The Authors have developed a rapid, simple and reproducible procedure for the preparation of hemoglobin free of stromal or other soluble and insoluble cellular contaminants. The procedure is based on crystallization of the hemoglobin molecule and repeated washings of crystals prior to solubilization and sterilization.
Fast algorithm for estimating the regional mechanical function of the left ventricle from 4D cardiac CT data (2014)

Cardiac pathologies are generally associated with regional ventricular dysfunction. Methods for estimating the regional myocardial motion from cardiac CT image data generally ignore the rotational velocities. Reasons for this include the challenges of sparse image deformation clues, low SNR and the low temporal resolution. In the current study we propose a fast algorithm for evaluating the mechanical function of the left ventricle from cardiac CT data. A compact parametric motion model is used to describe the regional 3D contraction and twist. The algorithm is based on regularized multi-homography image registration. The rotational velocities are estimated and compared to their respective values in the literature, with good agreement. Good performance in classifying the segments as normal or abnormal with respect to expert's visual scores is obtained.
In situ diode laser fenestration: An ex‐vivo evaluation of irradiation effects on human aortic tissue (2019)

The in situ laser fenestration is an interesting option for the endovascular treatment of short-necked aneurysms with an intraoperative modification of a standard endograft. According to literature evidence, diode laser emitting in the near-infrared wavelength (810 nm) can be successfully used to fenestrate the endograft fabric. This paper describes a three-dimensional navigation system for the accurate targeting of the fenestration site, then reports results of an ex vivo study to assess whether the laser operative conditions, which ensure the fabric fenestration, are harmless for the biological tissue surrounding the endoprosthesis. Two hundred twenty-five samples of human aorta, including healthy specimens and abdominal aortic aneurysm samples, were irradiated ex vivo using a 810 nm diode laser. Energy and pulse duration were varied. Irradiated tissues were fixed in formaldehyde, sectioned and subjected to histological examination. Only 7.5% of the irradiated samples exhibited a thermal damage, which was always confined to the contact point between the laser fiber tip and the aortic wall. These experiments suggest that the diode laser can be safely used for the proposed surgical application.
Fascism Revived? The Association Stands Guard, 1947-52 (1998)

This article documents a little-known aspect of Australia’s ‘secret history’. At the height of the Cold War in the late 1940s and early 1950s, an Australia-wide paramilitary organisation known as T...
Summary of the 5thPropulsion Aerodynamics Workshop: Inlet Cross-Flow Results (2022)

View Video Presentation: https://doi.org/10.2514/6.2022-0814.vid The 5thAIAA Propulsion Aerodynamics Workshop (PAW5) was held as part of the virtual Science and Technology Forum on January 9th -10th 2021. The goal of the workshop was to evaluate the current capability of computational fluid dynamics (CFD) on complex flows relevant to the propulsion community. The inlet portion of PAW5 focused on an axisymmetric inlet in pure cross-flow near a ground plane. Although geometrically simple, the axisymmetric inlet provided greater resolution of the ingested flow by rotating with the internal instrumentation to sample the flow at more locations than is possible with a typical instrumentation rake. Eleven participating organizations presented their work on the inlet portion of the workshop including 9 CFD solvers, 13 turbulence models, and 200 solution sets. The simulations covered 3 cross-flow velocities with 4 mesh levels provided by the PAW5 inlet committee in addition to meshes developed by participants. In general, solvers were better able to match the test data at the lowest cross-flow velocity regardless of mesh refinement, turbulence model, or solver, though two-equation turbulence models tended to match the distortion metric better than one-equation models. At higher cross-flows, the internal flow began to separate on the windward side of the inlet. The interactions between the separation and the ingested ground vortex hindered accurate predictions by most of the solvers. Moving the outflow boundary farther downstream improved the comparison for some simulations at the highest cross-flow velocities, but additional studies are still needed to ensure the computational model accurately represents the test configuration.
New Betaclamycin and Aclarubicin Analogs Obtained by Prolonged Microbial Conversion with an Aclarubicin-negative Mutant. (1996)

Microbial conversion of beta-rhodomycinone and aklavinone using an aclarubicin-negative Streptomyces galilaeus mutant afforded new anthracycline antibiotics CG21-C and CG1-C which had a rednosyl-2-deoxyfucosyl-rhodosaminyl trisaccharide residue at C-7 of each added aglycone. They were produced only when a prolonged conversion culture took place. Because the usual conversion products containing a cinerulosyl-2-deoxyfucosyl-rhodosaminyl residue were at first accumulated and then decreased during further cultivation, it was evident that they occurred by the modification of terminal cinerulose. The isolation, purification, and structural determination are described, and cytotoxicity in vitro against cultured L1210 cells and the formation mechanism are discussed.
The Lehman Brothers Bankruptcy D: The Role of Ernst & Young (2014)

For many years prior to its demise, Lehman Brothers employed Ernst & Young (EY) as the firm’s independent auditors to review its financial statements and express an opinion as to whether they fairly represented the company’s financial position. EY was supposed to try to detect fraud, determine whether a matter should be publicly disclosed, and communicate certain issues to Lehman’s Board audit committee. After Lehman filed for bankruptcy, it was discovered that the firm had employed questionable accounting with regard to an unorthodox financing transaction, Repo 105, which it used to make its results appear better than they were. EY was aware of Lehman’s use of Repo 105, and its failure to disclose its use. EY also knew that Lehman included in its liquidity pool assets that were impaired. When questioned, EY insisted that it had done nothing wrong. However, Anton R. Valukas, the Lehman bankruptcy examiner, concluded that EY had not fulfilled its duties and that probable claims existed against EY for malpractice. In this case, participants will consider the role and effectiveness of independent auditors in ensuring complete and accurate financial statements and related public disclosure.
Structural Evidence for Ultrafast Polarization Rotation in Ferroelectric/Dielectric Superlattice Nanodomains (2021)

Weakly coupled ferroelectric/dielectric superlattice thin-film heterostructures exhibit complex nanoscale polarization configurations that arise from a balance of competing electrostatic, elastic, and domain-wall contributions to the free energy. A key feature of these configurations is that the polarization can locally have a significant component that is along the thin-film surface normal direction with an overall configuration maintaining zero net in-plane polarization. PbTiO 3 =SrTiO 3 thin-film superlattice heterostructures on a conducting SrRuO 3 bottom electrode on SrTiO 3 have a room-temperature stripe nanodomain pattern with a nanometer-scale lateral period. Ultrafast time-resolved x-ray free electron laser diffraction and scattering experiments reveal that above-bandgap optical pulses induce propagating acoustic pulses and a perturbation of the domain diffuse scattering intensity arising from the nanoscale stripe domain configuration. With 400-nm optical excitation, two separate acoustic pulses are observed: a high-amplitude pulse resulting from strong optical absorption in the bottom electrode and a weaker pulse arising from the depolarization-field-screening effect due to absorption directly within the superlattice. The picosecond scale variation of the nanodomain diffuse scattering intensity is consistent with a larger polarization change than would be expected due to the polarization-tetragonality coupling of uniformly polarized ferroelectrics. The polarization change is consistent, instead, with polarization rotation facilitated by the reorientation of the in-plane component of the polarization at the domain boundaries of the striped polarization structure. The complex steady-state configuration within these ferroelectric heterostructures leads to ultrafast polarization rotation phenomena that have previously been available only through the selection of bulk crystal composition.
The Death Domain Superfamily in Intracellular Signaling of Apoptosis and Inflammation (2007)

The death domain (DD) superfamily comprising the death domain (DD) subfamily, the death effector domain (DED) subfamily, the caspase recruitment domain (CARD) subfamily, and the pyrin domain (PYD) subfamily is one of the largest domain superfamilies. By mediating homotypic interactions within each domain subfamily, these proteins play important roles in the assembly and activation of apoptotic and inflammatory complexes. In this chapter, we review the molecular complexes assembled by these proteins, the structural and biochemical features of these domains, and the molecular interactions mediated by them. By analyzing the potential molecular basis for the function of these domains, we hope to provide a comprehensive understanding of the function, structure, interaction, and evolution of this important family of domains.
OXYGEN DIFFUSION THROUGH HORSERADISH PEROXIDASE (1990)

Abstract— The quenching by molecular oxygen of the fluorescence from a protoporphyrin IX adduct of horseradish peroxidase has been investigated using both intensity and time‐resolved techniques. The bimolecular quenching rate constant determined for this process, as evaluated by the conventional Stern‐Volmer analysis, was 2 × 10 8 M −1 s −1 , among the lowest observed for protein systems. This result suggests that the heme binding site in horseradish peroxidase is relatively inaccessible to oxygen, which may account for the observation of room temperature phosphorescence in aerated solutions from enzymatically created triplet states.
Expression of hepatitis C virus in hepatocellular carcinoma (1994)

These findings suggest that HCV persists in hepatocytes during malignant transformation, although secondary infection of tumor cells by HCV cannot be excluded. Some HCC appear to support replication and expression of HCV.
The Ongoing March of Decentralisation within the Post-Jacobin State (2008)

The unification of French society by political elites took many centuries. Despite the continuous efforts of the Jacobin elites, the Code civil, the single currency, the accord between Church and State, wars, the influence of trade unions, parties and the Church, not to mention railways, municipalities and schools, unification remained elusive. Local and regional diversity in France only really became blurred in the 1960s, with the advent of a large welfare state, industrialisation and urbanisation, mass consumption and television. Modernists of the 1960s regarded the preservation of regional peculiarities as an archaic pursuit of traditions on the verge of extinction. The political nationalisation of local elections and the modernisation of the Fifth Republic were perceived as the continuation of State-led modernisation and direction of French society.
HHV-6 and HHV-7 as exogenous agents in human lymphocytes. (1992)

Human herpesviruses 6 and 7 (HHV-6 and HHV-7), the newly recognized lymphotropic members of the herpesvirus family, were isolated from peripheral blood mononuclear cells (PBMC) of healthy individuals. HHV-7 was recovered from PBMC after exposing the cells to conditions leading to T cell activation. No virus could be recovered from quiescent non-activated cultures, suggesting that the virus resided latently in these cells and that it could be induced from latency by T cell activation. HHV-6 could not be recovered from PBMC using similar approaches. However, it could be repeatedly reactivated from PBMC after infection of the cells with HHV-7. Upon further passaging in culture, HHV-6 took over the population and virus stocks appeared to be clear of the original HHV-7 helper virus. The results of this study suggest that genomes of the lymphotropic herpesviruses are resident in PBMC of healthy adults. HHV-7 can supply the functions required for its reactivation from latency. It can also act as a helper virus for the reactivation of HHV-6 from latency. Following the initial reactivation step, HHV-6 can replicate autonomously in the cells. These results may be relevant to the findings that HHV-6 infection is induced in immunosuppressed patients and in patients undergoing organ transplantation. Furthermore, these studies may exemplify situations whereby propagation of known agent(s) in vitro results in the activation of human pathogens resident latently in the cells.
Keyless Covert Communication in the Presence of Non-causal Channel State Information (2019)

We consider the problem of covert communication over a state-dependent channel, for which the transmitter and the legitimate receiver have non-causal access to the channel state information. Covert communication with respect to an adversary, referred to as the “warden,” is one in which the distribution induced during communication at the channel output observed by the warden is identical to the output distribution conditioned on an inactive channel-input symbol. Covert communication involves fooling an adversary in part by a proliferation of codebooks; for reliable decoding at the legitimate receiver the codebook uncertainty is removed via a shared secret key that is unavailable to the warden. Unlike earlier work in state-dependent covert communication, we do not assume the availability of a shared key at the transmitter and legitimate receiver. Rather, a shared randomness is extracted at the transmitter and the receiver from the channel state, in a manner that keeps the shared randomness secret from the warden despite the influence of the channel state on the warden's output. An inner bound on the covert capacity, in the absence of an externally provided secret key, is derived.
Mast Cell Subsets and Their Functional Modulation by theAcanthocheilonema viteaeProduct ES-62 (2013)

ES-62, an immunomodulator secreted by filarial nematodes, exhibits therapeutic potential in mouse models of allergic inflammation, at least in part by inducing the desensitisation of Fc ε RI-mediated mast cell responses. However, in addition to their pathogenic roles in allergic and autoimmune diseases, mast cells are important in fighting infection, wound healing, and resolving inflammation, reflecting that mast cells exhibit a phenotypic and functional plasticity. We have therefore characterised the differential functional responses to antigen (via Fc ε RI) and LPS and their modulation by ES-62 of the mature peritoneal-derived mast cells (PDMC; serosal) and those of the connective tissue-like mast cells (CTMC) and the mucosal-like mast cells derived from bone marrow progenitors (BMMC) as a first step to produce disease tissue-targeted therapeutics based on ES-62 action. All three mast cell populations were rendered hyporesponsive by ES-62 and whilst the mechanisms underlying such desensitisation have not been fully delineated, they reflect a downregulation of calcium and PKC α signalling. ES-62 also downregulated MyD88 and PKC δ in mucosal-type BMMC but not PDMC, the additional signals targeted in mucosal-type BMMC likely reflecting that these cells respond to antigen and LPS by degranulation and cytokine secretion whereas PDMC predominantly respond in a degranulation-based manner.
ATM mediates oxidative stress-induced dephosphorylation of DNA ligase IIIα (2006)

Among the three mammalian genes encoding DNA ligases, only the LIG3 gene does not have a homolog in lower eukaryotes. In somatic mammalian cells, the nuclear form of DNA ligase IIIalpha forms a stable complex with the DNA repair protein XRCC1 that is also found only in higher eukaryotes. Recent studies have shown that XRCC1 participates in S phase-specific DNA repair pathways independently of DNA ligase IIIalpha and is constitutively phosphorylated by casein kinase II. In this study we demonstrate that DNA ligase IIIalpha, unlike XRCC1, is phosphorylated in a cell cycle-dependent manner. Specifically, DNA ligase IIIalpha is phosphorylated on Ser123 by the cell division cycle kinase Cdk2 beginning early in S phase and continuing into M phase. Interestingly, treatment of S phase cells with agents that cause oxygen free radicals induces the dephosphorylation of DNA ligase IIIalpha. This oxidative stress-induced dephosphorylation of DNA ligase IIIalpha is dependent upon the ATM (ataxia-telangiectasia mutated) kinase and appears to involve inhibition of Cdk2 and probably activation of a phosphatase.
Lucia Travaini, La monetazione nell'Italia normanna. (1996)

Martin J.-M. Lucia Travaini, La monetazione nell'Italia normanna.. In: Revue numismatique, 6e série - Tome 151, année 1996 pp. 361-366.