gebhart/patrepeval huggingface dataset:
Evidence that the MIF2 gene of Saccharomyces cerevisiae encodes a centromere protein with homology to the mammalian centromere protein CENP-C. (1995)

The MIF2 gene of Saccharomyces cerevisiae has been implicated in mitosis. Here we provide genetic evidence that MIF2 encodes a centromere protein. Specifically, we found that mutations in MIF2 stabilize dicentric minichromosomes and confer high instability (i.e., a synthetic acentric phenotype) to chromosomes that bear a cis-acting mutation in element I of the yeast centromeric DNA (CDEI). Similarly, we observed synthetic phenotypes between mutations in MIF2 and trans-acting mutations in three known yeast centromere protein genes-CEP1/CBF1/CPF1, NDC10/CBF2, and CEP3/CBF3B. In addition, the mif2 temperature-sensitive phenotype can be partially rescued by increased dosage of CEP1. Synthetic lethal interactions between a cep1 null mutation and mutations in either NDC10 or CEP3 were also detected. Taken together, these data suggest that the Mif2 protein interacts with Cep1p at the centromere and that the yeast centromere indeed exists as a higher order protein-DNA complex. The Mif2 and Cep1 proteins contain motifs of known transcription factors, suggesting that assembly of the yeast centromere is analogous to that of eukaryotic enhancers and origins of replication. We also show that the predicted Mif2 protein shares two short regions of homology with the mammalian centromere Ag CENP-C and that two temperature-sensitive mutations in MIF2 lie within these regions. These results provide evidence for structural conservation between yeast and mammalian centromeres.
A Dual Method for Computing Power Transfer Distribution Factors (2016)

Power Transfer Distribution Factors (PTDFs) play a crucial role in power grid security analysis, planning, and redispatch. Fast calculation of the PTDFs is therefore of great importance. In this paper, we present a non-approximative dual method of computing PTDFs. It uses power flows along topological cycles of the network but still relies on simple matrix algebra. At the core, our method changes the size of the matrix that needs to be inverted to calculate the PTDFs from N × N, where N is the number of buses, to (L - N + 1) × (L - N + 1), where L is the number of lines and L - N + 1 is the number of independent cycles (closed loops) in the network while remaining mathematically fully equivalent. For power grids containing a relatively small number of cycles, the method can offer a speedup of numerical calculations.
Novel family of polylactide-based copolymer matrix composites by RTM process (2022)

International audience
ChemInform Abstract: Synthesis of Unsymmetrically Substituted 1,4‐Dihydropyridines and Analogous Calcium Antagonists by Microwave Heating. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
[Study of quantitative detection of circulating DNA in the plasma of patients with cervical lesion]. (2011)

Quantitatively detecting plasma circulating DNA may be with some application prospect in the diagnosis of cervical diseases.
Los caballos sacrificados del yacimiento tartésico de Casas del Turuñuelo (Guareña, Badajoz): un estudio multidisciplinar (2020)

Los primeros caballos domésticos aparecieron en las estepas euroasiáticas hace unos 5000 años. Desde entonces y a lo largo de la historia reciente de la humanidad, el caballo ha servido para multitud de tareas. Entender de qué manera las distintas sociedades sacaron provecho de este animal y de sus parientes más cercanos (asnos y sus híbridos, las mulas y burdéganos), permite conocer de manera directa el grado de complejidad tecnológica y social de esas sociedades concretas (Fages et al. 2019).&#13;\nLa Edad del Hierro fue una etapa de especial importancia en la península ibérica, debido a que las poblaciones autóctonas recibieron influencias de otros pueblos procedentes de distintas zonas del Mediterráneo y de la fachada atlántica de Europa. Además, para estas sociedades peninsulares, el caballo fue un animal singular que&#13;\nfue utilizado para distintas finalidades: transporte, conflictos bélicos, como símbolo de poder y prestigio social y más esporádicamente, como fuente de alimento. De hecho, algunos autores han definido al caballo como el animal protagonista de la Edad del Hierro, debido a su presencia y sus implicaciones en la ritualidad de distintas zonas&#13;\ndel Mediterráneo antiguo, incluida la península ibérica. La importancia de este animal fue tal, que se ha propuesto al caballo como el mejor indicador para conocer la evolución de los cambios socioeconómicos ocurridos desde la Edad del Bronce hasta la época romana. Durante los últimos años, nuestro conocimiento sobre la Primera Edad del Hierro del valle medio del río Guadiana se ha visto incrementado gracias al estudio de su poblamiento y al hallazgo del yacimiento tartésico de Casas del Turuñuelo (Guareña, Badajoz). El estado de conservación del edificio y los materiales&#13;\nque lo acompañan permiten considerarlo uno de los yacimientos arqueológicos más relevantes de la Protohistoria mediterránea. Las razones son numerosas, pero se pueden resumir en tres conceptos principales: 1) la documentación de unas estructuras arquitectónicas inéditas para la época, 2) la recuperación de ricos materiales arqueológicos procedentes de diversas partes del Mediterráneo y 3) la presencia de un sacrifico numeroso de animales o hecatombe, relacionado claramente&#13;\ncon un acto de carácter ritual. Además, y para mayor espectacularidad de este hallazgo, la mayoría de estos animales son équidos. Este descubrimiento ha&#13;\nsupuesto un catalizador para que alrededor del Turuñuelo y de sus équidos sacrificados, se haya formado un equipo multidisciplinar de arqueólogos, arqueozoólogos, veterinarios y biólogos especialistas en ADN antiguo, con unos&#13;\nobjetivos concretos: reunir toda la información posible de estos équidos y con ella, conocer mejor a la sociedad tartésica que los sacrificó.
.beta.-Epimerization and .gamma.-hydrogen abstraction via homoenolate ions (1976)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT.beta.-Epimerization and .gamma.-hydrogen abstraction via homoenolate ionsA. Nickon, J. L. Lambert, J. E. Oliver, D. F. Covey, and J. MorganCite this: J. Am. Chem. Soc. 1976, 98, 9, 2593–2599Publication Date (Print):April 1, 1976Publication History Published online1 May 2002Published inissue 1 April 1976https://pubs.acs.org/doi/10.1021/ja00425a031https://doi.org/10.1021/ja00425a031research-articleACS PublicationsRequest reuse permissionsArticle Views170Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Symbolic Formulation of Dynamic Equations For a Manipulator With Rigid and Flexible Links (1994)

The objective of this article is to present an efficient proce dure for computer generation of the dynamic equations for a planar robot manipulator with arbitrarily assigned rigid or flexible links using any desired flexible mode shape functions. The dynamic equations for the serial link manipulator are derived using Lagrange's formulation and elastic deflection with the assumed-mode method. Fewer approximations are made than in other approaches, resulting in greater accuracy. A method to determine the centrifugal and Coriolis matrix is presented that yields an important structural property. The approach is systematic and allows a symbolic program to be written in Mathematica using a system of several groups and a constructed database. Four examples are illustrated to verify the dynamic equations. The stability of the zero dynamics is compared for different mode shape functions.
Neodymium: YAG contact laser photocoagulation of the in vivo canine epicardium: Dosimetry, effects of various lasing modes, and histology (1993)

Significant linear correlation was found between the total delivered energy and all measured lesion parameters. Transmural lesions were found at energy levels of 270-480 J. Maximum depth measured up to 1.68 cm; at high energies, it was limited by myocardial thickness only. At constant energy levels, power and lasing time did not independently affect lesion dimensions; lasing mode and fiber mode had statistically significant but minor effects. Laser lesions were homogeneous and sharply demarcated without epicardial crater or endocardial thrombus formation. Endocardial surface cooling by circulating blood and the presence of epicardial vessels resulted in modifications in lesion morphology. In 29 out of 74 grossly transmural lesions, there was a 0.082 +/- 0.127 cm thin surviving subendocardium. Forty-five coagulation lesions were truly transmural with no surviving myocardial strands. In conclusion, contact epicardial LPC can result in deep, transmural myocardial coagulation lesions. Lesion dimensions can be adequately controlled by total delivered energy. Closed heart epicardial Nd:YAG laser photocoagulation could become a new, less invasive surgical technique for the treatment of drug-resistant ventricular tachycardia.
Microbial degradation of the herbicide atrazine and its 2-hydroxy analog in submerged soils (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMicrobial degradation of the herbicide atrazine and its 2-hydroxy analog in submerged soilsKishore P. Goswami and Richard Ervin GreenCite this: Environ. Sci. Technol. 1971, 5, 5, 426–429Publication Date (Print):May 1, 1971Publication History Published online1 May 2002Published inissue 1 May 1971https://pubs.acs.org/doi/10.1021/es60052a007https://doi.org/10.1021/es60052a007research-articleACS PublicationsRequest reuse permissionsArticle Views198Altmetric-Citations61LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Functional properties of 8S globulin fractions from 15 mung bean (Vigna radiata (L.) Wilczek) cultivars (2015)

Summary The functional properties including solubility, water absorption capacity, oil absorption capacity, foaming properties and emulsifying properties of 8S globulin fractions from 15 mung bean cultivars were investigated in this study. In addition, the effects of pH on solubility, foaming properties and emulsifying properties were studied. The functional properties of the 8S globulin fractions varied significantly among the different mung bean varieties and exhibited better performance in solubility and emulsion stability compared with soya bean 7S protein. A negative correlation was found between water absorption capacity and oil absorption capacity. Remarkable differences in polypeptides constituents were observed in 8S globulin fractions, and the ratio of 11S/8S globulins has a positive effect on water absorption capacity while a negative effect on oil absorption capacity. As a function of pH , the emulsifying activity indexes of the 8S globulin fractions were found to be distinctly dependent on the solubility, while no significant correlation was found between the emulsifying stability and solubility, nor between the foaming properties and solubility. The foaming capacity showed a strong correlation with foam stability.
Latest results at Amplitude on high power ns laser: application to dynamic shock compression (2022)

We will present in this paper the latest development made in the frame of High repetition rate PW laser. Increasing the repetition rate in high energy laser requires to master a lot of different parameters and especially the cooling and the reliability. We have worked in this direction in the frame of two projects: ELI ALPS in hungaria and HIBEF in Germany. We will show in the talk the developments that we have accomplished to reach at the same time a high energy and a high average power: specific pump laser (50J at 10Hz), High average power cryo cooling. We will also focus on the reliability of these systems and present the results gathered during the last months.
Variable Structure Observer for Control Bias on Unmanned Air Vehicles (2006)

b = span c = chord L,M, N = aerodynamic moment components in the body reference frame p, q, r = components of the angular velocity of the system in the body reference frame S = reference area u, v, w = components of the velocity vector of the system mass center in the body frame VA = total aerodynamic velocity of the system X, Y, Z = aerodynamic force components in the body reference frame x, y, z = components of the position vector of the system mass center in an inertial frame max M = largest eigenvalue of the matrixM , , = Euler roll, pitch, and yaw angles of the system
322 Evaluation of the biological function of genes linked to regions with distortion of Mendelian segregation and their relation to reproductive traits in dairy cattle. (2018)

Distortion of the Mendelian segregation or transmission ratio distortion (TRD) refers to the significant departure from Mendel’s law of the transmission of alleles from heterozygous parents to offspring. This phenomenon has been attributed to various biological mechanisms before fertilization, during fetal and embryonic development and in neonatal life. Thus, TRD has been associated with impaired fertility and offspring survival at embryonic, fetal and postnatal stages. The objective of this study was to evaluate the functional consequences of genomic regions showing TRD in a population of 436,651 Holstein dairy cattle with trios of raw genotypes. Genotype data (trios) included genotypes from dam, sire and offspring using medium and high density SNP arrays. Functional analysis included 877 positional genes associated with all SNPs previously identified as displaying strong significant TRD (Bayes Factor ≥10), using a Bayesian approach. Gene ontology (GO) and network analyses were performed using WebGestalt and STRING software. The GO analysis showed significant biological processes related to embryonic stages, such as regulation of mitotic cell cycle, stem cell population maintenance, skeletal system morphogenesis or forebrain development. In addition, the genes within significant TRD regions were further investigated performing gene networks analysis. A total of 849 specific and meaningful connections between the genes were detected (p-value< 1.0e-16), meaning that there were more associations between genes related to TRD than the ones that could be expected by chance. The highest enriched metabolic pathway in the gene network was the regulation of actin cytoskeleton. This pathway has been linked to sprouting of neurites in early embryonic differentiation. Hence, functional analyses on TRD regions showed that the positional candidate genes might have a direct impact on embryo development. Additional data mining approaches will be performed to identify key regulator genes, which may harbor potential structural variations that directly affect reproductive traits in dairy cattle.
Analytical and experimental studies on the characteristics of composite solid-state laser rods in diode-end-pumped geometry (1997)

In this paper, we report analytical and experimental studies on the characteristics of end-pumped composite laser rods with undoped end, using mainly Nd:YAG rods as an example. It is found that the peak temperature rise in a composite rod decreases to <70% of that in a noncomposite crystal. Thermal stress is dramatically reduced to <60% by employing the composite rod structure, We also demonstrate high-power operation of the diode-end-pumped composite Nd:YVO/sub 4/ rod and a maximum CW output power of 9.3 W was achieved, which is about 1.5 times higher than that in the noncomposite rod. This high-power performance of the composite rod is primarily attributed to the reduction of thermal stress inside the rod.
Zinc-catalyzed alkynylation of acetals via oxocarbenium ion intermediates (2025)

Reactions that allow the conversion of a simple achiral or racemic starting material into an enantiomerically pure product are of great importance. Such processes are particularly advantageous when they are combined with the formation of a carbon-carbon bond. In the large majority of such reactions, stereoselectivity is controlled by enzymes, chiral auxiliaries, organocatalysts, or transition metal catalysts. In particular, enantioselective transition metal catalysis is a powerful tool in the synthesis of enantioenriched products. The M. Watson group has recently demonstrated a new enantioselective metal-catalyzed strategy for the addition of terminal alkynes to racemic isochroman and chromene acetals. This thesis describes my progress towards establishing this alkynylation strategy for a much broader class of cyclic acetal substrates. The first chapter reviews developments in enantioselective additions of carbon nucleophiles to prochiral cyclic oxocarbenium ions using both organocatalysis and transition metal catalysis. The chapter briefly discusses the addition of carbon nucleophiles to aldehydes and ketones catalyzed by transition metals, as well as enantioselective alkynylation of iminium ions. The second chapter of this thesis describes my work on alkynylation of chroman acetals through cyclic oxocarbenium ions, specifically optimization of reaction conditions and my progress towards an asymmetric version of this reaction. The third chapter discusses diastereoselective alkynylation reactions. In addition to the routes for substrate synthesis for these studies, the alkynylation of several nonbenzopyranyl substrates through aliphatic oxocarbenium ion intermediates has been achieved. This work establishes that the alkynylation strategy previously used for the addition of terminal alkynes to racemic isochroman and chromene acetals can be applied to a much broader class of cyclic acetal substrates, in particular chroman, tetrahydrofuran, and tetrahydropyran acetals.
Negative refractions and backward waves in biaxially anisotropic chiral media (2006)

We investigate the refraction and propagation properties of electromagnetic waves which are incident from free space to a biaxially anisotropic chiral medium. Such a chiral medium can be realized by putting chiral elements pointing to two directions into a host medium. When the host medium is a normally isotropic dielectric, no negative refraction and/or backward waves are supported for the propagating eigenwaves in the chiral medium. When the host medium changes to an anisotropic dielectric or an electric plasma, however, negative refractions and backward waves can be realized separately or even simultaneously if we choose the medium parameters properly. Numerical simulations validate our theoretical analysis.
Covariance in protein multiple sequence alignments using groups of columns (2014)

Algorithms that detect covariance between pairs of columns in multiple sequence alignments are commonly employed to predict functionally important residues and structural contacts. However, the assumption that co-variance only occurs between individual residues in the protein is more driven by computational convenience rather than fundamental protein architecture. Here we develop a novel algorithm that defines a covariance score across two groups of columns where each group represents a stretch of contiguous columns in the alignment. We define a test set that consists of secondary structure elements (α-helixes and β-strands) across more than 1,100 PFAM families. Using these alignments to predict segments that are physically close in structure, we show that our method substantially out-performs approaches that aggregate the results of algorithms that operate on individual column pairs. Our approach demonstrates that considering units of proteins beyond pairs of columns can improve the power and utility of covariance algorithms.
Isothermal Titration Calorimetry: A Tutorial (2004)

This chapter contains sections titled: Introduction Thermodynamic characterization Instrumentation Raw data Basic considerations for experimental set-up Data analysis Summary Application notes Acknowledgement References
Tensor visualizations in computational geomechanics (2002)

Abstract We present a novel technique for visualizing tensors in three dimensional (3D) space. Of particular interest is the visualization of stress tensors resulting from 3D numerical simulations in computational geomechanics. To this end we present three different approaches to visualizing tensors in 3D space, namely hedgehogs, hyperstreamlines and hyperstreamsurfaces. We also present a number of examples related to stress distributions in 3D solids subjected to single and load couples. In addition, we present stress visualizations resulting from single‐pile and pile‐group computations. The main objective of this work is to investigate various techniques for visualizing general Cartesian tensors of rank 2 and it's application to geomechanics problems. Copyright © 2002 John Wiley &amp; Sons, Ltd.