gebhart/patrepeval huggingface dataset:
Multi-Environment based Meta-Learning with CSI Fingerprints for Radio Based Positioning (2023)

Radio based positioning of a user equipment (UE) based on deep learning (DL) methods using channel state information (CSI) fingerprints have shown promising results. DL models are able to capture complex properties embedded in the CSI about a particular environment and map UE’s CSI to the UE’s position. However, the CSI fingerprints and the DL models trained on such fingerprints are highly dependent on a particular propagation environment, which generally limits the transfer of knowledge of the DL models from one environment to another. In this paper, we propose a DL model consisting of two parts: the first part aims to learn environment independent features while the second part combines those features depending on the particular environment. To improve transfer learning, we propose a meta learning scheme for training the first part over multiple environments. We show that for positioning in a new environment, initializing a DL model with the meta learned environment independent function achieves higher UE positioning accuracy compared to regular transfer learning from one environment to the new environment, or compared to training the DL model from scratch with only fingerprints from the new environment. Our proposed scheme is able to create an environment independent function which can embed knowledge from multiple environments and more effectively learn from a new environment.
Tsinghua Hephaestus 2014 AdultSize Team Description (2014)

This document describes both hardware and software specications and practical functions of the humanoid robot THU-Strider, developed by team Tsinghua Hephaestus as a platform for research in bipedal locomotion, robot self-localization and multi-robot cooperation. The robot will also be used to par- ticipate in Humanoid League(AdultSize) of RoboCup 2014 Brazil.
Prediction of MHC Binding Peptides and Epitopes from Alfalfa mosaic virus (2007)

Peptide fragments from alfalfa mosaic virus involved multiple antigenic components directing and empowering the immune system to protect the host from infection. MHC molecules are cell surface proteins, which take active part in host immune reactions and involvement of MHC class-I & II in response to almost all antigens. Coat protein of alfalfa mosaic virus contains 221 aa residues. Analysis found five MHC ligands in coat protein as 64-LSSFNGLGV-72; 86- RILEEDLIY-94; 96-MVFSITPSY-104; 100- ITPSYAGTF-108; 110- LTDDVTTED-118; having rescaled binding affinity and c-terminal cleavage affinity more than 0.5. The predicted binding affinity is normalized by the 1% fractil. The MHC peptide binding is predicted using neural networks trained on c-terminals of known epitopes. In analysis predicted MHC/peptide binding is a log transformed value related to the IC50 values in nM units. Total numbers of peptides found are 213. Predicted MHC binding regions act like red flags for antigen specific and generate immune response against the parent antigen. So a small fragment of antigen can induce immune response against whole antigen. This theme is implemented in designing subunit and synthetic peptide vaccines. The sequence analysis method allows potential drug targets to identify active sites against plant diseases. The method integrates prediction of peptide MHC class I binding; proteosomal c-terminal cleavage and TAP transport efficiency.
Effects of Clozapine on Substance Use in Patients With Schizophrenia and Schizoaffective Disorder: A Retrospective Survey (2000)

Substance use disorders, particularly those involving alcohol, marijuana, and cocaine, are highly prevalent among patients with schizophrenia and contribute markedly to its overall morbidity. Unfortunately, standard (typical) antipsychotic medications do not seem to reduce substance use in patients with schizophrenia and may even increase it. Recently, however, a few anecdotal case reports and two previous small "N" surveys have found that clozapine, an atypical antipsychotic medication, seems to decrease substance use in patients treated with this drug for their psychoses. The authors report data from a retrospective survey of substance use in 58 patients treated with clozapine who had a history of comorbid schizophrenia (or schizoaffective disorder) and substance use disorder. Of these 58 patients, 43 were being treated with clozapine at the time of the survey; the remaining 15 patients had discontinued clozapine before the survey. The survey involved chart review and clinician interview to assess change in substance use and global clinical symptoms while receiving treatment with clozapine. More than 85% of the patients who were active substance users at the time of initiation of treatment with clozapine decreased their substance use over the course of clozapine administration. For patients who continued treatment with clozapine up to the present, the decrease in substance use was strongly correlated with a decrease in global clinical symptoms. Data from this retrospective survey further support the previous observations that clozapine reduces substance use among patients with schizophrenic disorders. Moreover, the data suggest the need for prospective controlled studies of the effects of clozapine on substance use in this population.
Updated results of a phase 1 study combining the matrix metalloproteinase 9 inhibitor GS-5745 with gemcitabine and nab-paclitaxel in patients with advanced pancreatic cancer. (2017)

363 Background: GS-5745 is a monoclonal antibody inhibitor of matrix metalloproteinase 9 (MMP9), an extracellular enzyme involved in matrix remodeling, tumor growth, and metastasis. We present data from patients (pts) with advanced pancreatic adenocarcinoma enrolled in an ongoing multi-indication phase 1 study (NCT01803282) evaluating GS-5745. Methods: Following a monotherapy dose finding stage, pts with locally advanced or metastatic pancreatic cancer received gemcitabine (G) + nab-paclitaxel (Abraxane, A) and GS-5745 800 mg IV every 2 weeks. Treatment continued until disease progression, unacceptable toxicity or withdrawal of consent. Response was assessed every 8 weeks per RECIST version 1.1 criteria. Results: As of April 2016, 36 pts were enrolled (1 continues to receive GS-5745). The most frequently observed adverse events (AEs) of any grade include fatigue (75%), alopecia (55.6%), peripheral edema (55.6%) and nausea (50%). Grade ≥ 3 AEs observed in ≥ 10% of pts included neutropenia (25%), anemia (19.4%) and fatigue (13.9%). The median progression free survival (PFS) for all pts is 7.8 (90% confidence interval (CI) = [6.1, 11]) months (mos), median duration of response (DOR) is 5.8 mos and the objective response rate (ORR) is 44.4%. Of the 31 pts who were treatment naïve in the metastatic setting, median PFS is 9.2 (90% CI = [6.1, 11]) mos, median DOR 5.8 mos and the ORR 51.6%. Median baseline circulating MMP9 was 44.3 (range 12.4-549.6) ng/mL and 31 of 32 patients with post-baseline samples had undetectable MMP9 levels within 8 weeks. Conclusions: GS-5745+GA demonstrated numerically higher ORR and PFS compared to historical data without additional toxicity. Additionally, reductions in circulating MMP9 levels post treatment suggest target engagement by GS-5745 . These results suggest this combination may warrant additional study in first line metastatic pancreatic adenocarcinoma. Clinical trial information: NCT01803282.
Transfer ribonucleic acid biosynthesis. Substrate specificity of ribonuclease P. (1976)

Bacteriophage T4 synthesizes proline and serine tRNA species which are derived from a common precursor RNA. The processing of this precursor RNA involves the replacement of a U-A-A terminus in serine tRNA by C-C-A prior to precursor cleavage. In the present work we have examined in detail the cleavage of T4 proline-serine precursor RNA by the previously identified ribonuclease P. Ribonuclease P accurately cleaves precursor RNA terminating in either C-C-A or U-A-A to generate the 5' termini characteristic of both mature tRNA species. These cleavages do not depend solely on the nucleotide sequence of the precursor RNA since isolated oligonucleotides spanning the cleavage sites are not substrates for the enzyme. Two types of experiments show that RNase P kinetically favors precursor RNA ending C-C-A over that ending U-A-A. Isolated preparations of precursor RNA containing the C-C-A sequence were cleaved more rapidly by RNase P than precursor RNA ending U-A-A. In addition, the serine tRNA generated by limited cleavage of a mixed population of precursor RNA ending C-C-A or U-A-A was enriched 3-fold in the C-A-A sequence relative to the starting material. Bacteriophage T4 proline-serine precursor RNA, in contrast to other tRNA precursors, accumulates in measurable amounts in wild type cells. This accumulation would appear to be a consequence of the requirement for the generation of the C-C-A sequence prior to RNase P cleavage. The enzymic specificity of RNase P in vitro therefore reflects the in vivo pathway for serine tRNA biosynthesis, where the C-C-A sequence is synthesized while the serine tRNA sequence is still a part of the large precursor RNA.
Neodymium-YAG Vitreous Surgery for Phakic and Pseudophakic Malignant Glaucoma (1986)

Ciliary block (malignant glaucoma) developed in a phakic eye and a pseudophakic eye with a posterior chamber intraocular lens and an intact posterior capsule. In both cases, neodymium-YAG laser treatment (2 to 3 mJ) to the anterior vitreous relieved the blockage, and the anterior chamber returned to normal depth. When technically possible, the neodymium-YAG laser may be used to treat phakic and pseudophakic malignant glaucoma before resorting to surgical vitrectomy.
On the Philosophy of Subjectivity Education in China (2012)

This paper discusses the definition of the philosophical term subjectivity made by Chinese philosophers and the application of the philosophical subjectivity in Subjectivity Education led by Dina Pei and her associates. Subjectivity is the manifestation of the attributes of the subject in his objectification activity, mainly including autonomy, activeness and creativity. Subjectivity Education grafts the theories onto educational theories and has conducted experiments on a nation-wide scale in the past twenty years all over China. Subjectivity Education is leading Education in China from tradition to modernity.
Oxidation-induced traps near SiO2/SiGe interface (1999)

Using an Al/SiO2(wet)/Si0.9Ge0.1/n–Si/Al capacitor structure, effects of oxidation on bulk trap and interface states near the SiO2/SiGe interface are investigated. Two peaks at the energy levels of 0.23 eV (D1) and 0.40 eV (D2) below the conduction band edge are observed with the capacitance deep level transient spectroscopy (DLTS) method. The DLTS measurement results show a characteristic feature of interface states for the D1 peak. The interface state distribution obtained by the capacitance–voltage method also has a high density (6.9×1012/cm2 eV) peak at an energy level of 0.23 eV below the conduction band edge. The Si–O– dangling bonds are thought to be the source of the D1 peak. The annealing behaviors of the D2 peak show that D2 is a divacancy related bulk trap. The capture cross section and the trap density for the bulk trap D2 are 2.06×10−15/cm2 and 1.8×1014/cm3, respectively. The density of D2 is significantly reduced after low temperature postmetallization annealing.
Rapid motions in protein molecules. (1981)

Rapid motions of protein molecules can be detected by optical techniques that exploit short light pulses. Nanosecond fluorescence polarization studies have shown that whole domains of proteins such as immunoglobin G and myosin can rotate over an appreciable angular range of times of nanoseconds. This type of motion, called segmental flexibility, may be characteristic of many large proteins and molecular assemblies. Time-resolved fluorescence polarization studies have also demonstrated that internal tryptophan residues in some proteins, such as azurin, are quite flexible in the subnanosecond time range. Vary rapid conformational transitions of chromophoric groups can also be viewed by resonance Raman spectroscopy, which displays vibrations that are coupled to electronic transitions. In these experiments, intense light pulses are used to trigger a change in a photolabile molecule. The resonance Raman spectrum of rhodopsin photolysed by a 30 ps pulse from a Nd:YAG laser exhibits lines that are characteristic of a distorted all-trans retinal chromophore. This finding suggest that much of the cis-trans isomerization of retinal is accomplished within a few picoseconds of the absorption of a photon by rhodopsin. The emerging picture is that proteins can be designed by nature to allow very rapid motions of selected regions.
Natriuretic peptide pathways in heart failure: further therapeutic possibilities (2022)

The discovery of the heart as an endocrine organ resulted in a remarkable recognition of the natriuretic peptide system (NPS). Specifically, research has established the production of atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) from the heart, which exert pleiotropic cardiovascular, endocrine, renal, and metabolic actions via the particulate guanylyl cyclase A receptor (GC-A) and the second messenger, cGMP. C-type natriuretic peptide (CNP) is produced in the endothelium and kidney and mediates important protective auto/paracrine actions via GC-B and cGMP. These actions, in part, participate in the efficacy of sacubitril/valsartan in heart failure (HF) due to the augmentation of the NPS. Here, we will review important insights into the biology of the NPS, the role of precision medicine, and focus on the phenotypes of human genetic variants of ANP and BNP in the general population and the relevance to HF. We will also provide an update of the existence of NP deficiency states, including in HF, which provide the rationale for further therapeutics for the NPS. Finally, we will review the field of peptide engineering and the development of novel designer NPs for the treatment of HF. Notably, the recent discovery of a first-in-class small molecule GC-A enhancer, which is orally deliverable, will be highlighted. These innovative designer NPs and small molecule possess enhanced and novel properties for the treatment of HF and cardiovascular diseases.
Intrusion Prevention and Detection in Wireless Sensor Networks (2008)

In this thesis, we concentrate on the study and design of distributed security algorithms for sensor networks that prevent the attacker from accessing the information routed within or injecting malicious packets. We also study the problem of detecting the attacker when the prevention measures cannot succeed and she intrudes the network. For each of the proposed solutions we emphasize on minimizing the overhead imposed by its implementation on widely used sensor platforms, so that it becomes realistic and attractive to the developer.
Wavelet packet and adaptive spatial transformation of watermark for digital image authentication (2002)

A general watermarking scheme which adopts the multiresolution wavelet packet transform and content based watermarking scheme has been developed for a digital image. The systematic approach of the watermarking includes the selection of the image content, the wavelet packet transform and the implementation of total automorphism as the spatial transform for the watermark. To efficiently embed the watermark within the images and provide the robustness for the watermark detection under attacks, a modular based element classification and adjustment of the wavelet transformed coefficients has been utilized in this research. Instead of using the random number generator to create the watermark, the meaningful and recognizable seal image has been used as the watermark which provides immediately strong authentication information. In addition, the parameter settings of the choices among the transforms serve as the key information in deciphering an watermarked image without referring to the original image. Compared with other watermarking methods, our technique provides a generalized approach for watermarking with robustness.
CO2Nucleation in Membrane Spacer Channels Remove Biofilms and Fouling Deposits (2010)

The decline in membrane performance due to both biofouling and particulate fouling is a major issue for membranes in the water treatment industry. In spiral wound modules, commonly used in reverse osmosis and nanofiltration, the presence of feed spacers results in an increased potential of fouling. We describe a novel cleaning method to be used in the restoration of membrane module performance. The method described here involves the use of water saturated with dissolved CO2 at higher pressures and rinsing of the fouled membrane/spacer channel at a lower pressure. Due to depressurization, bubbles nucleate at spacer filaments and improve the cleaning efficacy significantly. The study compared the cleaning efficacy of three methods in the removal of fouling from a membrane/spacer channel; water rinsing, water/N2 sparging, and water/CO2 (dissolved) nucleation. Using water rinsing, 40% of the fouling on the spacer-filled channel could be removed; a water/N2 mixture removed 85% of the fouling. With the dissolved water/CO2, there was complete removal of the fouling (all measured as restoration of the hydraulic resistance of the clean channels). Such an efficient tool to recover the performance of severely fouled desalination membrane modules could replace or reduce today’s expensive, sensitive, and chemically intensive cleaning processes.
Detection of Inducible Nitric Oxide Synthase and Vascular Endothelial Growth Factor in Choroidal Neovascular Membranes (2002)

Vascular endothelial growth factor (VEGF) is among the cytokines which have been implicated in the pathogenesis of choroidal neovascularization secondary to age-related macular degeneration (ARMD). There is, however, evidence that intercellular signaling molecules, such as nitric oxide (NO), are involved in this process. NO is synthesized via the inducible isoform of NO synthase (iNOS), which is expressed after induction by cytokines. In the current study, we investigated whether VEGF and iNOS are coexpressed in choroidal neovascular membranes (n = 7) from patients with ARMD. Immunohistochemistry was performed on cryosections with anti-iNOS and anti-VEGF. Moderate to intense immunostaining for iNOS and VEGF was observed in retinal pigment epithelial cells, macrophages, and in spatial relation to vessel walls. As scored by light microscopy, we found a significant correlation between immunoreactivity for VEGF and iNOS (p < 0.0341) in vascular endothelial cells. Our study supports a significant role for iNOS in the pathogenesis of neovascularization and membrane growth in ARMD. Moreover, our findings suggest a possible relationship between NO and VEGF in the regulation of pathologic angiogenesis in this disease.
Pharmacology of fragrance: odors and GPCRs (2014)

Odor receptors are the largest family of GPCR’s on the planet. The identification of this large family of genes by Buck and Axel in 1991 showed that they have much in common with the other 450 or so GPCRs found in the mammalian genome. From this one might imagine that they can be profitably studied by using techniques developed for standard GPCR pharmacology – ligand screening, structure activity relations, and a variety of modeling techniques. We have utilized synthetic chemistry to examine the structure-function activity of an odor receptor by utilizing a variety of synthetically designed ligands that demonstrate mechanisms for agonism, antagonism, partial agonism and reverse agonism. These analyses provide a theoretical picture of the requirements for a binding region within the receptor. The existence of a range of ligands – from antagonists to high affinity agonists - for a given receptor must be taken into account when considering the type of upstream brain circuits that might be required to reduce the complex diversity of odor stimuli to the simpler categories of fragrance perception. In addition to these common principles of pharmacology that can be applied profitably to odor receptors we suggest that the techniques and strategies of medicinal chemistry, normally targeted to a single specific receptor (e.g., dopamine, epinephrine, serotonin) can be modified for use in a large and varied receptor population. The med chem concept of bioisosterism, for example, may help to better define our thinking about broad and narrow tuning in receptors when applied to large numbers of receptors.
Time-Recursive Computation, Part II: Methodology, and Application on QMF Banks and ELT (1993)

Recent advances in ISDN have promoted applications such as video- phone, tele-conferencing and HDTV, that demand real-time processing of large volume audio, video and speech data. Being the only refuge for this intense computation, the VLSI technology favors modular and regular designs with local communication requirements. In this light, the framework for time-recursive computation, presented in part I [7] of this two-part paper, provides the background for designing efficient VLSI implementations, capable of accommodating high throughput requirements. In part II, we develop a routine that can be used for designing the time-recursive architecture of a given linear operator in a systematic manner. Three classes of QMF banks are used as design examples: the lossless QMF bank, the cosine modulated QMF bank and two Extended Lapped Transforms, one of them being the Modulated Lapped Transform (MLT). In addition to demonstrating the use of the design procedure, these examples provide novel results, interesting on their own right. In particular, the time-recursive architecture we propose for an N - point MLT, also known as Modified DCT or Time Domain Aliasing Cancellation (TDAC) transform, requires 2N + 3 multipliers, 3N + 3 adders and N - 1 rotation circuits.
Saitohin gene is not associated with Alzheimer's disease (2003)

No evidence was found for an association of the non-synonymous polymorphism (Q7R) in STH and Alzheimer's disease. This finding is in line with earlier studies showing no association between MAPT and Alzheimer's disease.
Retrieving Web Pages Using Content, Links, URLs and Anchors (2002)

For this year&amp;apos;s web track, we concentrated on the entry page finding task. For the content-only runs, in both the ad-hoc task and the entry page finding task, we used an information retrieval system based on a simple unigram language model. In the Ad hoc task we experimented with alternatieve approaches to smoothing. For the entry page task, we incorporated additional information into the model. The sources of information we used in addition to the document&amp;apos;s content are links, URLs and anchors. We found that almost every approach can improve the results of a content only run. In the end, a very basic approach, using the depth of the path of the URL as a prior, yielded by far the largest improvement over the content only results. 1
Supplementary Table from PGC1α/β Expression Predicts Therapeutic Response to Oxidative Phosphorylation Inhibition in Ovarian Cancer (2023)

Supplementary Table from PGC1α/β Expression Predicts Therapeutic Response to Oxidative Phosphorylation Inhibition in Ovarian Cancer
Sorafenib blocks tumour growth, angiogenesis and metastatic potential in preclinical models of osteosarcoma through a mechanism potentially involving the inhibition of ERK1/2, MCL-1 and ezrin pathways (2009)

In conclusion, ERK1/2, MCL-1 and ERM pathways are shown to be active in OS. Sorafenib is able to inhibit their signal transduction, both in vitro and in vivo, displaying anti-tumoural activity, anti-angiogenic effects, and reducing metastatic colony formation in lungs. These data support the testing of sorafenib as a potential therapeutic option in metastatic or relapsed OS patients unresponsive to standard treatments.