gebhart/patrepeval huggingface dataset:
Strategies for Human Papillomavirus Therapeutic Vaccines and Other Therapies Based on the E6 and E7 Oncogenes (2005)

High-risk human papillomaviruses (HR-HPVs) are one of the most devastating oncogenic viruses worldwide and have been causally linked with the development of human cervical cancer. Several prophylactic and therapeutic clinical HPV vaccine trials are in progress. Although prophylactic vaccines are useful in preventing the incidence of cervical cancer, the elimination of existing HPV infections needs to be addressed, because cervical cancer is the leading female cancer in developing countries. Several different and encouraging strategies have been investigated in a preclinical and clinical setting for the treatment and elimination of existing HPV-induced infection. This review summarizes the therapeutic clinical trials and the different preclinical research strategies that are under investigation whereby HR-HPV E6 and E7 oncogenes are delivered in a nucleic acid form, in viral and bacterial vectors, or as peptide- and protein-based vaccines.
Resonance energy-transfer and fluorescence intensity studies of the transport of liposome-encapsulated molecules into isolated mouse liver nuclei (1987)

We present evidence that liposomes (composed of egg yolk L-alpha-phosphatidylcholine/phosphatidylethanolamine/cholesterol, in a molar ratio of 4:5:1) fuse with isolated mouse liver nuclei at low pH. Using the resonance energy-transfer assay, we determined the rate and extent of liposome and nuclear membrane lipid mixing. Fusion was substantial when the pH was below 5. The half-time of lipid mixing decreased by acidification of the solvent, reaching about 2 min at pH 4.5. In order to study the transport of the liposome-aqueous contents to the interior of the nuclei during the process, we developed fluorescence assays in which fluorescein isothiocyanate labeled dextrans of 150 kDa molecular mass (FITC-D150) were encapsulated in liposomes. These liposomes also included in their bilayers the fluorescent lipid N-tetramethylrhodamine-L-alpha-dipalmitoylphosphatidylethanolamine (N-Rh-DPPE). After incubation of these liposomes with mouse liver nuclei (pH 4.5, 37 degrees C, 30 min), we measured the fluorescence spectra of a suspension of washed nuclei and of nuclei treated by the detergent Triton X-100 (membrane-denuded nuclei). These Triton X-100 treated nuclei had no N-Rh-DPPE fluorescence while they showed a FITC-D150 fluorescence which amounted to 20% of that of the intact nuclei. In another assay, a laser beam was focused on single nuclei by a microscope epiexcitation device. The variation of the N-Rh-DPPE and FITC-D150 fluorescence with the nuclear radius was determined with the microphotometric attachment of the microscope.(ABSTRACT TRUNCATED AT 250 WORDS)
Fairness, Semi-Supervised Learning, and More: A General Framework for\n Clustering with Stochastic Pairwise Constraints (2021)

Metric clustering is fundamental in areas ranging from Combinatorial\nOptimization and Data Mining, to Machine Learning and Operations Research.\nHowever, in a variety of situations we may have additional requirements or\nknowledge, distinct from the underlying metric, regarding which pairs of points\nshould be clustered together. To capture and analyze such scenarios, we\nintroduce a novel family of \\emph{stochastic pairwise constraints}, which we\nincorporate into several essential clustering objectives (radius/median/means).\nMoreover, we demonstrate that these constraints can succinctly model an\nintriguing collection of applications, including among others \\emph{Individual\nFairness} in clustering and \\emph{Must-link} constraints in semi-supervised\nlearning. Our main result consists of a general framework that yields\napproximation algorithms with provable guarantees for important clustering\nobjectives, while at the same time producing solutions that respect the\nstochastic pairwise constraints. Furthermore, for certain objectives we devise\nimproved results in the case of Must-link constraints, which are also the best\npossible from a theoretical perspective. Finally, we present experimental\nevidence that validates the effectiveness of our algorithms.\n
REAL TIME WEARABLE MUSCLE FUNCTIONAL IMAGER (2001)

The well-known runman NIR tissue spectrometer has achieved notable success in skeletal muscle spectroscopy of relative desaturation of hemoglobin and myoglobin and total hemoglobin changes in the deoxygenation and increased flow in limb exercise. Heterogeneity of response depending upon pennation and fascicle differences requires images in at least 2-D in order to localize the particular portion of the exercised muscle at maximal metaoblic and vascular responses. While stationary exercise is useful, it may fail to clearly reproduce the muscle image in an athlete's speciality. Thus, a wearable “runman” (Omron) has been most useful but fails to provide images of muscle function. Novel featurs of lamp pulsing and gated data acquisition, together with good power economy, now makes possible scans of 20 sources and dual wavelength detectors in 1.1 sec and present the image in 0.1 sec thereafter. The new principle affords images of localized muscle activation with a 1 centimeter (squared) resolution of relative deoxygenation and blood concentration changes. These patterns differ among individuals and their changes during exercise near Vmax may be of use as a training aid.
Thermal conductivity profile in the Nankai accretionary prism at IODP NanTroSEIZE Site C0002: estimations from high-pressure experiments using input site sediments (2020)

Depth profiles of sediment thermal conductivity are required for understanding the thermal structure in active seismogenic zones. During the Nankai Trough Seismogenic Zone Experiment (NanTroSEIZE), a scientific drilling project of the International Ocean Discovery Program, a borehole penetrated to a depth of 3262.5 meters below seafloor (mbsf) at site C0002. Because core samples obtained from below ~1100 mbsf in an accretionary prism are limited, a thermal conductivity profile over such depths usually determined by laboratory measurements using core samples is not available. To obtain the thermal conductivity profile at site C0002, we used core samples collected from sediments that overlay the in-coming subducting oceanic basement at NanTroSEIZE site C0012, which can be considered to have the same mineral composition as the accretional prism at site C0002. The thermal conductivity of the C0012 core samples was measured at high pressure to simulate subduction by reducing the sample porosity. We measured the thermal conductivity of six core samples from 144–518 mbsf at site C0012 up to a maximum effective pressure of ~50 MPa, corresponding to depths greater than ~4 kmbsf. We obtained an empirical relation between thermal conductivity and fractional porosity for the Nankai Trough accretionary prism as = exp(-1.09φ+0.977). Based on porosity data measured using core/cuttings samples and data derived from P-wave velocity logs, we estimate two consistent and complete thermal conductivity profiles down to ~3 kmbsf in the Nankai Trough accretionary prism. These profiles are consistent with the existing thermal conductivity data measured using limited core samples.
Emerging Human Ehrlichioses: Recently Recognized, Widely Distributed, Life-Threatening Tick-Borne Diseases (2014)

Phylogenetic analysis based on 16S rRNA gene homology places organisms currently designated Ehrlichia spp. within three different clusters. The theme of evolution for survival as obligately intracellular organisms within insects and ticks seems to characterize most of those bacteria well, except for those in the group containing Ehrlichia sennetsu and Neorickettsia helminthoeca. The etiologic organisms of human monocytotropic ehrlichiosis (HME) and human granulocytotropic ehrlichiosis (HGE) have surely been present on Earth for eons. The body of knowledge provided by veterinary scientists, including techniques to cultivate some of the Ehrlichia spp. as antigens for immunofluorescence serology and descriptions of their microscopic and ultrastructural appearance, facilitated the identification of the etiologic agent of HME as an Ehrlichia sp. Increasing numbers of commercial laboratories are offering serologic and PCR diagnostic assays for the diagnosis of the human ehrlichioses. A commercial laboratory with the most experience in the diagnosis of HME, demonstrated the presence of antibodies to E. chaffeensis in 1,136 serum specimens between October 1991 and May 1996. Cell culture recovery of the HGE agent in HL60 cells (a human myeloid cell line) has yielded more isolates than recovery of E. chaffeensis has in DH82 cells. HGE is treated successfully with doxycycline with the same doses as for HME. Based on cell culture antimicrobial susceptibility studies, rifampin, rifabutin, and selected fluoroquinolones show promise as alternative drugs that might prove useful in situations such as pregnancy.
Bandwidth Conversion of ELF Noise Parameters (1984)

The Field-Lewinstein-Modestino model represents ELF noise as the sum of Gaussian and impulsive components. This model has proven to be accurate and is especially convenient for analysis and simulation. However, the parameters of the model are bandwidth dependent and have been measured for only a few specific bandwidths. No method of calculating the parameters for other bandwidths has been presented. This paper derives such a method by equating the second and fourth moments of the impulsive component of the ELF noise at the input and output of the filter.
Selfcooling resonance torsional vibration damper (1981)

First Page
SarsaLandmark: an algorithm for learning in POMDPs with landmarks (2009)

Reinforcement learning algorithms that use eligibility traces, such as Sarsa(λ), have been empirically shown to be effective in learning good estimated-state-based policies in partially observable Markov decision processes (POMDPs). Nevertheless, one can construct counterexamples, problems in which Sarsa(λ &amp;lt; 1) fails to find a good policy even though one exists. Despite this, these algorithms remain of great interest because alternative approaches to learning in POMDPs based on approximating belief-states do not scale. In this paper we present SarsaLandmark, an algorithm for learning in POMDPs with ”landmark ” states (most man-made and many natural environments have landmarks). SarsaLandmark simultaneously preserves the advantages offered by eligibility traces and fixes the cause of the failure of Sarsa(λ) on the motivating counterexamples. We present a theoretical analysis of SarsaLandmark for the policy evaluation problem and present empirical results on a few learning control problems.
3D Speckle Intensity Correlations in Propagation of Optical Vortex Beams (2021)

We developed an analytical model for 3D spatial cross-correlations in speckles fields generated by scattering of structured beams. Specific properties identified for different types of optical vortices can guide their use in remote sensing applications.
A Linear-implicit Quantized Devs Method for Very Stiff Electrical Networks Using a Latency Insertion Method (2020)

A Linear-Implicit Quantized State System (LIQSS) method is combined with a Latency Insertion Method (LIM) to create a practical and efficient approach for simulating the dynamics of very stiff electrical systems. The LIQSS method is used to asynchronously update each state in the system, where the LIM modeling method is used to decouple the electrical system model at the individual node level making the asynchronous solution possible. The DEVS specification for the QDL method is presented along with the detailed simulation procedure. The combined method is validated by simulating a 40-state network model with a stiffness ratio of 109.
Chemical Stability of CuWO4 for Photoelectrochemical Water Oxidation (2013)

Pure-phase CuWO4 photoanodes with 200 nm thickness were produced by spin-casting sol–gel precursors to evaluate their performance as photoelectrodes for water oxidation. The stability of CuWO4 in potassium phosphate (KPi) and potassium borate (KBi) buffers was evaluated as a function of pH and irradiance. CuWO4 photoanodes demonstrate higher stability at pH 3 and 5 in a 0.1 M KPi buffer and are significantly more stable over a 12 h period of illumination in a 0.1 M KBi buffer at pH 7 (∼75 μA/cm2 photocurrent at 1.23 V vs RHE (reversible hydrogen electrode) and 1 sun illumination) than in a 0.1 M KPi buffer at pH 7. The onset of photoelectrochemical water oxidation and electrochemical O2 reduction is dictated by Cu(3dx2–y2) states that reside at 0.4 V vs RHE, determined by linear sweep voltammetry. The onset for water oxidation is hindered by a large charge-transfer resistance, as high as 4.6 kΩ at 1 V vs RHE. Nevertheless, CuWO4 photoanodes show nearly quantitative faradic efficiency for water oxidation, even in the presence of chloride, an improvement over the binary oxide WO3.
Directional-modulation-enabled physical-layer wireless security (2017)

Directional modulation (DM), as a promising keyless physical-layer security technique, has rapidly developed within the last decade. This technique is able to directly secure wireless communications in the physical layer by virtue of the property of its direction-dependent signal-modulation-formatted transmission. This chapter reviews the development in DM technology over recent years and provides some recommendations for future studies.
Ultrafast photoinduced dynamics of halogenated cyclopentadienes: observation of geminate charge-transfer complexes in solution (2013)

The photoinduced dynamics of the fully halogenated cyclopentadienes C5Cl6 and C5Br6 have been investigated in solution and gas phase by femtosecond time-resolved spectroscopy. Both in solution and in gas phase, homolytic dissociation into a halogen radical and a C5X5 (X = Cl, Br) radical was observed. In liquid phase, solvent-dependent formation of charge transfer complexes between geminate radicals was observed for the first time. These complexes were found to be surprisingly stable and offered the opportunity to follow the dynamics of specific radical pairs. In the case of C5Cl6 in trichloroethanol, a reaction of the chlorine radical with molecules from the solvent cage was observed.
Katalytische enantioselektive Retro-Aldolreaktion: kinetische Racematspaltung von β-Hydroxyketonen durch Aldolase-Antikörper (1998)

Hohe Enantiomerenanreicherung nach 50 % Umsatz: Racemate von Aldolen konnten durch die Titelreaktion [Gl. (1)] mit den Aldolase-Antikörpern 38C2 und 33F12 gespalten werden; die ee-Werte der nicht umgesetzten Aldole betrugen in den meisten Fällen >95 %. Weil die Antikörper auch die Aldolreaktion, also die Rückreaktion, katalysieren, ist es möglich, beide Enantiomere mit einem einzigen katalytischen Antikörper zu synthetisieren.
Endovascular versus open surgical repair for complicated chronic type B aortic dissection (2018)

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:
Evaluation of performance of the CPET scanner using standardized measurement techniques (2002)

We report on our evaluation of the CPET (ADAC/UGM) and compare the different results obtained according to the IEC (61675-1, 1998), NEMA (NU-2, 1994) and updated NEMA (NEMA 2000+) protocols. The latter uses phantoms more clinically relevant for whole-body studies. The CPET has six curved NaI(Tl) detectors (2.54 cm thick) and no septa. The ring diameter is 90 cm with a patient port of 56 cm, and the axial FOV is 25.6 cm. The energy resolution is 11% and the lower energy threshold is set at 435 keV. The spatial resolution for a point (line) source in the transaxial direction is 4.6 (4.7) mm (FWHM) on the scanner axis, and the axial resolution is 5.7 mm. Following the NU-2 analysis, the scatter fraction is 25%, the sensitivity is 12.7 cps/Bq/ml, and the peak noise equivalent countrate (NEC) is 47.4 kcps at an activity concentration of 12.3 kBq/ml. For the IEC protocol, the scatter fraction is 31.6%, the sensitivity is 11.6 cps/Bq/ml, and the peak NEC is 39.5 kcps at 12.3 kBq/ml. For the NEMA 2000+ protocol, the scatter fraction is 35.0%, the sensitivity is 3.0 cps/kBq (note the change in units), and the peak NEC is 14 kcps at 3.8 kBq/ml. Compared to the previous Penn-PET scanners, upon which the CPET is based, the use of curved detectors and improvements in the pulse-shaping, integration deadtime, and triggering lead to improved countrate capability, spatial resolution and image quality of the scanner. The current NEMA and IEC measurements (which use 19-cm long phantoms) characterize the best possible performance for PET imaging, while the new proposed measurements (using longer phantoms and point instead of line sources) better characterize the performance under clinical conditions, especially 3D whole-body scanning.
A Foregut Cystic Neoplasm with Diagnostic and Therapeutic Similarities to Mucinous Cystic Neoplasms of the Pancreas (2013)

Bronchogenic cysts are congenital anomalies of the ventral foregut that can migrate into the abdomen prior to fusion of the diaphragm. They can easily be misdiagnosed for other benign and malignant retroperitoneal lesions. Similarly to mucinous cystic neoplasms, bronchogenic cysts have been reported to undergo malignant transformation. They can also become infected and hemorrhage. Therefore, resection should be performed in appropriate risk candidates. It is possible, with increased use of high resolution cross-sectional imaging, that these lesions may be identified with greater frequency in the abdomen and confused with other pancreatic neoplasms. The presence of ciliated respiratory epithelium and cartilage on pathology provides for definitive diagnosis.
Impact of breast-feeding on Giardia lamblia infections in Bilbeis, Egypt. (2001)

A total of 152 infants were followed from birth to 1 year of age in a rural community of Egypt to document Giardia lamblia infection and to determine the effect of breast-feeding on enteric infections by this protozoan. Asymptomatic Giardia infections persisted as long as 4 months, with a mean duration of excretion of 7.18 weeks. The incidence of asymptomatic infection was 4.5 episodes per child-year. Exclusively breast-fed infants had lower risk for asymptomatic (odds ratio [OR] = 0.66, 95% confidence interval [CI] = 0.45-0.96, P < 0.05) and symptomatic infections (relative risk [RR] = 0.50, 95% CI = 0.27-0.90, P < 0.05). Furthermore, breast-fed infants had fewer clinical manifestations, including mucus in stool (23.8% versus 76.2%, P = 0.08), loss of appetite (17.6% versus 82.3%, P < 0.05), and abdominal tenderness (17% versus 82.9%, P < 0.05) compared with infants who were not exclusively breast-fed. Breast-feeding should be considered as an effective means to prevent Giardia infections and should be encouraged in regions where G. lambia is highly endemic.
Reuse of haemodialysers (1994)

Reuse of haemodialysers Get access S. Shaldon S. Shaldon Department of Nephrology, University HospitalNimes, France Correspondence and offprint requests to: Dr S. Shaldon, Department of Nephrology, University Hospital, 5 Rue Hoche, Nimes 30001, France. Search for other works by this author on: Oxford Academic PubMed Google Scholar Nephrology Dialysis Transplantation, Volume 9, Issue 9, 1994, Pages 1226–1227, https://doi.org/10.1093/ndt/9.9.1226 Published: 01 January 1994
Species dependence of mitochondrial respiration inhibition by strobilurin analogues (1994)

Conference Article| February 01 1994 Species dependence of mitochondrial respiration inhibition by strobilurin analogues FRANZ ROEHL; FRANZ ROEHL 1BASF AG Hauptlaboratorium, D-6700 Ludwigshafen, Germany Search for other works by this author on: This Site PubMed Google Scholar HUBERT SAUTER HUBERT SAUTER 1BASF AG Hauptlaboratorium, D-6700 Ludwigshafen, Germany Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1994) 22 (1): 63S. https://doi.org/10.1042/bst022063s Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation FRANZ ROEHL, HUBERT SAUTER; Species dependence of mitochondrial respiration inhibition by strobilurin analogues. Biochem Soc Trans 1 February 1994; 22 (1): 63S. doi: https://doi.org/10.1042/bst022063s Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1994 Biochemical Society1994 Article PDF first page preview Close Modal You do not currently have access to this content.
Short-Circuit Making of Medium Voltage Load Break Switches Using a Grid Connected Test Circuit (2018)

The load break switch is an important component in the distribution grid. Besides its capability to break load currents reliably, it has to be able to make short-circuit currents according to the IEC 62271 standard. In this paper, the process of making a short-circuit current and the used test methods are described. A synthetic test circuit using semiconductors instead of a triggered spark gap is proposed and described thoroughly. The basic working principle has been validated with simulations in Simulink.
Classical (M = osmium) and nonclassical (M = iron, ruthenium) polyhydride structures for the complexes MH4(PR3)3 (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTClassical (M = osmium) and nonclassical (M = iron, ruthenium) polyhydride structures for the complexes MH4(PR3)3Robert H. Crabtree and Douglas G. HamiltonCite this: J. Am. Chem. Soc. 1986, 108, 11, 3124–3125Publication Date (Print):May 1, 1986Publication History Published online1 May 2002Published inissue 1 May 1986https://doi.org/10.1021/ja00271a063RIGHTS & PERMISSIONSArticle Views509Altmetric-Citations93LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (303 KB) Get e-Alerts Get e-Alerts