gebhart/patrepeval huggingface dataset:
Exercise and Therapeutic Ultrasound in Skeletal Muscle Regeneration (2004)

0125 Following skeletal muscle contusion injury, ultrasound (US) is a commonly utilized treatment modality among sports medicine practitioners. There is evidence that the mechanical effects of non-thermal US elicit changes in membrane permeability, which over several days purportedly hastens the post-contusion-injury muscle regenerative process. However, how US influences both satellite cell proliferation and ultimately muscle contractile proteins is poorly understood, and the interaction between US and low-intensity exercise following contusion injury has not been investigated. PURPOSE: To gain enhanced insight into the biological markers underlying the potential rehabilitative process associated with US, and determine if low-intensity exercise (EX) enhances the effect of US treatment. METHODS: Twenty male Wistar rats (8–9 mo) were studied and were randomly assigned to either an EX or NoEX group. Following anesthesia, each rat received a bilateral contusion injury to the gastrocnemius (GTN) muscles. The reproducible injury was generated using a validated drop-mass technique. To visualize satellite cell proliferation, immediately following the contusion injury a pellet of the thymidine analog, bromodeoxyuridine, was implanted subcutaneously in the scruff of the neck. In both groups the right leg received US while the left received no US. The design lead to the generation of 4 groups of 10 GTN muscles: 1) EX + US; 2) EX + NoUS; 3) NoEX + US; and 4) NoEX + NoUS. An additional 5 animals served as a non-injured, − US treated, and− exercised control group. Both exercise and US treatments were administered for four consecutive days, and began 24h post-contusion-injury. Exercise treatment consisted of 20 minutes/day of low-intensity treadmill walking (14m/min), and the US treatments (settings = 0.1 W/cm2 and 3 MHz) were 5 minutes in duration. Left non-US treated legs received sham US treatments. Following all treatment protocols (96h) GTN muscles were surgically removed and rats were sacrificed. GTN muscles were weighed, frozen, and stored at−80°C for analysis of fiber cross-sectional area (CSAf), myofibrillar protein concentration, and satellite cell number. A two way (exercise × treatment) MANOVA was performed. RESULTS: Preliminary results from 5 rats in the NoEx group demonstrate no statistically significant (p<0.05) differences between US-treated and sham-treated muscles in mass (3.25 ± 0.22 g and 3.34 ± 0.23 g, respectively) nor in CSAf (1,600 ± 455.43 square microns and 1,549 ± 1,109.74 square microns, respectively). CONCLUSIONS: The US treatment protocol used appears to have no effect on the measured markers of skeletal muscle regeneration.
Enhanced performance of direct methanol fuel cells: a study on the combined effect of various supporting electrolytes, flow channel designs and operating temperatures (2013)

Establishing a better coordination between operating parameters and flow channel design is one of the most critical factors in achieving an optimum final performance of a fuel cell, since even a marginal change in any of the parameters can sharply affect the cell's performance. In this study, we report the use of three different acids, viz. sulphuric acid (H2SO4), formic acid (HCOOH) and phosphoric acid (H3PO4) as supporting electrolytes in combination with 2 M methanol fuel, wherein we demonstrated the effects of different combinations of acidic fuels and channel designs on the final cell performance. For this purpose, we made use of four different types of serpentine flow design. In the process, it was observed that an addition of 2 M concentrations of H2SO4 and H3PO4 enhanced the cell performance sharply in terms of current density, reaching values of 210 mAcm−2 and 180 mAcm−2, respectively, when analyzed at 0.2 V potential. This result was a considerable improvement over the current density value of 90 mAcm−2 achieved while using only 2 M methanol analyzed at the same potential. Moreover, the open-circuit voltage showed a value of greater than 0.6 V for both fuel samples. With a flow channel length of 650 mm (A5SF2) and at an open ratio of 52%, we obtained maximum power values of 42 mWcm−2 and 36 mWcm−2 for fuels containing 2 M H2SO4 (M2S2) and 2 M H3PO4 (M2P2), respectively, when analyzed at 70°C. Copyright © 2013 John Wiley & Sons, Ltd.
Acoustic Properties of Alumina Colloidal/Polymer Nano-Composite Film (2007)

[4]; however, it is difficult to obtain a homogeneous thin matching layer using 1.5-µm silver particles. Therefore, the conventional processing method of hand mixing metal particles with polymer matrix becomes very challenging for the fabrication of high-frequency composite matching layers with homogeneous properties. In this letter, we report the successful fabrication of an alumina colloidal/polymer composite film using the solgel coating process [5]. The particle size in the film is less than 50 nm and the uniformity of the properties is guaranteed even for submicron-thickness film. The acoustic properties of the nano-composite films with alumina content from 14% up to 32 wt % were measured at the operating frequency of the transducers, and it was found that the acoustic impedance is in the desired range. The fabrication process is as follows. Alumina colloidal was mixed with polymer in the presence of a coupling reagent and water. The hydroxyl group on the surface of the nano-alumina condensed with polymer to form a homogeneous nano-composite. Adhesion promoter was added to ensure good adhesion to the substrate. Ethanol was added to achieve the desired concentration of adhesion promoter. The desired concentration was determined by the ratio between the adhesive and ethanol. The mixture solution was deposited onto silicon substrate by spin coating at 2000 rpm for 30 seconds. The substrate was then placed on a hot plate to evaporate the solvent. Each film layer thickness was about 6–8 µm, and the sample was placed in an oven to age for a time period after each coating. The coating process was repeated until the desired thickness was achieved. Five samples with a thickness of 24 µm were prepared, and the alumina contents in these samples were 14%, 18%, 28%, 30%, and 32%, respectively. The cross-section scanning electron micrograph of the
Peroxisome Proliferator-Activated Receptor-γ(PPAR-γ) Agonists Attenuate the Profibrotic Response Induced by TGF-β1 in Renal Interstitial Fibroblasts (2007)

PPAR-gamma agonists could inhibit TGF-beta1-induced renal fibroblast activation, CTGF expression and ECM synthesis through abrogating the TGF-beta1/Smads signaling pathway.
Neuro-accuracy compensator for industrial robots (2002)

A nominal analytic kinematic model augmented by a neural network (NN) accuracy compensator has been used to determine accurately the relationship between robot world space co-ordinates and joint transducer readings. In contrast to model-based calibration approaches which have been used in an attempt to model and identify the specific error source, the NN-based calibration provides a generic model of robot accuracy which accounts for various errors, with the error source information being represented in the distributed network weight connections. A novel network architecture, based on Pi-sigma neural networks, has been designed so that it has sufficient approximations capability, which is equivalent to the higher-order polynomials, to approximate the relationship between the accuracy compensations (both in the world space and in joint space) and robot configurations, while maintaining an efficient network leaning ability. The authors' results for a full-pose calibration of a six DOF (degree of freedom) Puma 560 Robot have shown that the neural network approach can achieve better accuracy compared with the kinematic model-based calibration. The forward neuro-accuracy compensation (compensated in the world space) demonstrates a decrease in the average position and orientation error from 4.35 mm and 2.55 degree to 0.24 mm and 0.44 degree, in the range from 0.90 mm and 0.41 degree to 0.15 mm and 0.37 degree respectively in the calibrated area. In addition, error compensation is much more efficient than conventional numerical iterative compensation algorithms, suggesting that the neuro-accuracy compensator can be implemented on-line.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A Novel Nine-Level Quadruple Boost Inverter With Inductive-Load Ability (2019)

A novel single-phase nine-level switched-capacitor inverter (9LSCI) is presented with quadruple boost ability and reduced components. The proposed topology with single dc source employs only eight switches to realize nine-level output, self-voltage balance of capacitors, quadruple boost and inductive-load ability, thus, the effective cost is cut down compared to other switched-capacitor multilevel inverters (SCMLIs). Different from other SCMLIs, the proposed 9LSCI has no need for back-end H-bridge, of which four switches need to withstand the peak voltage of output. Hence, total standing voltage can be reduced. The operation principles containing the self-voltage balance of capacitors are described in detail. The quantitative comparisons, modified cost function, as well as the loss evaluations are examined in depth. Finally, multicarrier phase disposition pulsewidth modulation method is adopted and a laboratory prototype is implemented with the rated output of 220 V-500 W. The experimental results also verify the feasibility of the proposed topology.
Construction of polyomavirus-derived pseudotype virus-like particles displaying a functionally active neutralizing antibody against hepatitis B virus surface antigen (2015)

Polyomavirus-derived pseudotype VLPs harbouring multiple functionally active antibody molecules with virus-neutralizing capability may represent a novel platform for developing therapeutic tools with a potential application for post-exposure or therapeutic treatment of viral infections.
Apoptosis goes on a chip: advances in the microfluidic analysis of programmed cell death (2011)

Recent years have brought enormous progress in cell-based lab-on-a-chip technologies, allowing dynamic studies of cell death with an unprecedented accuracy. As interest in the microfabricated technologies for cell-based bioassays is rapidly gaining momentum, we highlight the most promising technologies that provide a new outlook for the rapid assessment of programmed and accidental cell death and are applicable in drug discovery, high-content drug screening, and personalized clinical diagnostics.
The development of mega-ampere contact structures for an electromagnetic launcher (1993)

The authors point out that electromagnetic launcher (railgun) development presents a challenging problem in electric contact design. The launcher requires mega-ampere peak currents with millisecond durations. The launcher segments require high-current joints capable of carrying the mega-ampere currents. High-current joints are also necessary to transfer the current from the distributed pulsed power capacitor banks to the railgun. Maintenance and repair of the railgun makes it necessary to disconnect the high-current joints. The evolution of the high-current contact design is discussed, and it is shown that the basic contact design criteria used for contact structures good over 100 kA can be extended to mega-ampere joints.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Repressor binding to a regulatory site in the DNA coding sequence is sufficient to confer transcriptional regulation of the vir-repressed genes (vrg genes) in Bordetella pertussis (1993)

Five TnphoA fusions to vir-repressed genes (vrg genes) have been identified in the respiratory pathogen Bordetella pertussis. A comparison of vrg DNA sequences suggests a consensus DNA element within the coding regions of four of five vrg genes. To determine the role of this DNA sequence in vrg regulation, a nucleotide substitution mutation in the conserved region of vrg-6 was isolated. This mutant showed constitutively high levels of expression in the absence of antigenic modulators, MgSO4 and nicotinic acid, suggesting that this DNA element may be a control site for vrg repression. Moreover, Northern (RNA) analysis and transcriptional fusion analysis suggest that vrg genes are regulated at the transcriptional level. To determine whether sequences in the coding region were sufficient to respond to antigenic modulation, a vrg-6::TnphoA promoter deletion plasmid that contained a heterologous promoter driving the expression of vrg-6 coding sequences from the vrg-6 translation start site to the TnphoA fusion junction was constructed. This heterologous construct responded to modulators in a vir-dependent fashion, indicating that sequences upstream of the coding sequence are not required for antigenic modulation. Southwestern (DNA-protein) analysis and mutational studies suggest that the vrg consensus DNA sequence is specifically recognized by a 34-kDa vir-activated gene (vag) product, whose binding results in down-regulation of vrg transcript levels. We conclude, at least for the vrg::TnphoA fusion strains, that a site on the DNA that corresponds to a consensus sequence located in the vrg coding region is sufficient to confer the transcriptional regulation (repression) of vrg genes when B. pertussis strains are grown under nonmodulating conditions.
Motion planning with diffusion maps (2016)

Many robotic applications require repeated, on-demand motion planning in mapped environments. In addition, the presence of other dynamic agents, such as people, often induces frequent, dynamic changes in the environment. Having a potential function that encodes pairwise cost-to-go can be useful for improving the computational speed of finding feasible paths, and for guiding local searches around dynamic obstacles. However, since storing pairwise potential can be impractical given the O(|V| <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ) memory requirement, existing work often needs to compute a potential function for each query to a new goal, which would require a substantial online computation. This work addresses the problem by using diffusion maps, a machine learning algorithm, to learn the map's geometry and develop a memory-efficient parametrization (O(|V|)) of pairwise potentials. Specially, each state in the map is transformed to a diffusion coordinate, in which pairwise Euclidean distance is shown to be a meaningful similarity metric. We develop diffusion-based motion planning algorithms and, through extensive numerical evaluation, show that the proposed algorithms find feasible paths of similar quality with orders of magnitude improvement in computational speed compared with single-query methods. The proposed algorithms are implemented on hardware to enable real-time autonomous navigation in an indoor environment with frequent interactions with pedestrians.
Dynamic Task Offloading and Scheduling for Low-Latency IoT Services in Multi-Access Edge Computing (2019)

Multi-access edge computing (MEC) has recently emerged as a novel paradigm to facilitate access to advanced computing capabilities at the edge of the network, in close proximity to end devices, thereby enabling a rich variety of latency sensitive services demanded by various emerging industry verticals. Internet-of-Things (IoT) devices, being highly ubiquitous and connected, can offload their computational tasks to be processed by applications hosted on the MEC servers due to their limited battery, computing, and storage capacities. Such IoT applications providing services to offloaded tasks of IoT devices are hosted on edge servers with limited computing capabilities. Given the heterogeneity in the requirements of the offloaded tasks (different computing requirements, latency, and so on) and limited MEC capabilities, we jointly decide on the task offloading (tasks to application assignment) and scheduling (order of executing them), which yields a challenging problem of combinatorial nature. Furthermore, we jointly decide on the computing resource allocation for the hosted applications, and we refer this problem as the Dynamic Task Offloading and Scheduling problem, encompassing the three subproblems mentioned earlier. We mathematically formulate this problem, and owing to its complexity, we design a novel thoughtful decomposition based on the technique of the Logic-Based Benders Decomposition. This technique solves a relaxed master, with fewer constraints, and a subproblem, whose resolution allows the generation of cuts which will, iteratively, guide the master to tighten its search space. Ultimately, both the master and the sub-problem will converge to yield the optimal solution. We show that this technique offers several order of magnitude (more than 140 times) improvements in the run time for the studied instances. One other advantage of this method is its capability of providing solutions with performance guarantees. Finally, we use this method to highlight the insightful performance trends for different vertical industries as a function of multiple system parameters with a focus on the delay-sensitive use cases.
The Transcriptional Co-activator ADA5 Is Required for HAC1 mRNA Processing in Vivo (2000)

Accumulation of unfolded proteins in the endoplasmic reticulum (ER) activates signaling pathways to induce transcription of a number of genes encoding ER protein chaperones and-folding catalysts. In Saccharomyces cerevisiae this transcriptional induction is mediated by an increase in the synthesis of the transcription factor Hac1p. The transmembrane receptor Ire1p/Ern1p containing a Ser/Thr protein kinase and endoribonuclease activity transmits the unfolded protein response (UPR) from the ER to the nucleus. Activation of Ire1p kinase induces its endoribonuclease activity to cleave unspliced HAC1 mRNA and generate exon fragments that are subsequently ligated by tRNA ligase (RLG1). Whereas unspliced HAC1 mRNA is poorly translated, spliced HAC1 mRNA is efficiently translated. Subunits of the yeast transcriptional co-activator complex SAGA also play a role in the UPR. Deletion of GCN5, ADA2, or ADA3 reduces, and deletion of ADA5 completely abolishes, the UPR. Although HAC1 mRNA requires only Ire1p and Rlg1p in vitro, we demonstrate that ADA5 is required for the IRE1/RLG1-dependent splicing reaction of HAC1 mRNA in vivo. In addition, Ada5p interacts with Ire1p. These results suggest that subcomponents of transcriptional co-activator complexes may be involved in RNA processing events.
Correlation of Serum FGF23 and Chronic Kidney Disease‐Mineral and Bone Abnormality Markers With Cardiac Structure Changes in Maintenance Hemodialysis Patients (2023)

Serum FGF23 showed a positive correlation among blood calcium levels and PTH levels in hemodialysis patients, and FGF23 levels can affect the incidence of right atrial hypertrophy in MHD patients.
A fast kinetics study of the modes of action of some different radiosensitizers in bacteria. (1978)

Using a fast mixing a irradiation technique, the gas explosion method, with Serratia marcescents, the decay of oxygen-dependent damage is found to consist of a fast and a slow stage, each of which is associated with a sub-component of this damage. In the present work, the interactions of these components with radiosensitizers are examined. At low concentrations O2, TAN (a nitroxyl) and misonidazole all preferentially sensitize the slow-stage damage. At higher concentrations, O2 and TAN sensitize the fast-stage damage by a fixation reaction that competes with its repair; in contrast, misonidazole appears mainly to operate by reaction with an earlier, ever shorter form of oxygen-dependent damage.
Hollow Silica Microparticles Based on Amphiphilic Polyphosphazenes (2022)

Hollow microparticles are important materials, offering a larger surface area and lower density than their solid counterparts. Furthermore, their inner void space can be exploited for the encapsulation and release of guest species in a variety of applications. Herein, we present phosphazene-based silica hollow microparticles prepared via a surfactant-free sol-gel process through self-assembly of the alkoxysilyl-containing polymer in water-ethanol solution. Solely, a silane-derived polyphosphazene was used as the precursor for the microparticle formation, without additional classical silica sources. These novel hollow silica-based microparticles were prepared without surfactant, using a designed amphiphilic polyphosphazene for the particle formation made by two components, a hydrophilic unit consisting of 3-mercaptopropyl(trimethoxysilane), and a hydrophobic unit (dodecanethiol) attached to the double bonds from the poly(allylamine)phosphazene backbone via a thiol-ene photoreaction. Due to these two functionalities, a "vesicle"-like self-assembled structure was formed in the reaction medium, which could be then utilized for the microparticle preparation. The influence of NaOH during the synthesis was shown to affect the size and the wall thickness of the microparticles. This effect may enhance the possibilities to tailor such microparticles for drug delivery purposes or for future controlled release of other substances, such as drugs, fragrances, or anticorrosive pigments.
New macrocyclic compounds from the secretions of the civet cat and the musk rat (1973)

Abstract The odoriferous glands of the civet cat and the musk rat contain not only the limited number of macrocyclic components described in the classical literature, such as civetone (9 cis ‐cycloheptadecenone), but a whole spectrum of saturated and unsaturated cyclic ketones and alcohols. In the musk rat, peculiar compounds containing conjugated and/or triple bonds were found; the unsaturation was located here exclusively at the 5 and/or 7 position. The macrocyclic alcohols were always esterified with long chain fatty acids. The absolute configuration of the dextrorotatory unsaturated alcohols was established as S. Some of the new compounds have been made in quantity by total organic synthesis, viz. 5‐cyclopentadecynone, 5 cis ‐cyclopentadecenone, 5‐cycloheptadecynone, 5 cis ‐cycloheptadecenone and 9 cis ‐cyclononadecenone.
Electrochemical Biocompatibility Testing of Zeolite Thin films on Titanium Alloys for Dental Implants (2008)

Abstract not Available.
An Overview Of The Stratelec Project (Stratéole-2 Atmospheric Electricity) (2022)

International audience
Effects of Column and Gradient Lengths on Peak Capacity and Peptide Identification in Nanoflow LC-MS/MS of Complex Proteomic Samples (2012)

Reversed-phase liquid chromatography is the most commonly used separation method for shotgun proteomics. Nanoflow chromatography has emerged as the preferred chromatography method for its increased sensitivity and separation. Despite its common use, there are a wide range of parameters and conditions used across research groups. These parameters have an effect on the quality of the chromatographic separation, which is critical to maximizing the number of peptide identifications and minimizing ion suppression. Here we examined the relationship between column lengths, gradient lengths, peptide identifications, and peptide peak capacity. We found that while longer column and gradient lengths generally increase peptide identifications, the degree of improvement is dependent on both parameters and is diminished at longer column and gradients. Peak capacity, in comparison, showed a more linear increase with column and gradient lengths. We discuss the discrepancy between these two results and some of the considerations that should be taken into account when deciding on the chromatographic conditions for a proteomics experiment.