gebhart/patrepeval huggingface dataset:
Mutations in TSPAN12 Cause Autosomal-Dominant Familial Exudative Vitreoretinopathy (2010)

Familial exudative vitreoretinopathy (FEVR) is an inherited blinding disorder of the retinal vascular system. Although mutations in three genes (LRP5, FZD4, and NDP) are known to cause FEVR, these account for only a fraction of FEVR cases. The proteins encoded by these FEVR genes form part of a signaling complex that activates the Norrin-beta-catenin signaling pathway. Recently, through a large-scale reverse genetic screen in mice, Junge and colleagues identified an additional member of this signaling complex, Tspan12. Here, we report that mutations in TSPAN12 also cause autosomal-dominant FEVR. We describe seven mutations identified in a cohort of 70 FEVR patients in whom we had already excluded the known FEVR genes. This study provides further evidence for the importance of the Norrin-beta-catenin signaling pathway in the development of the retinal vasculature and also indicates that more FEVR genes remain to be identified.
Chapter 11. Evaluation of an online, task-based Chinese course (2014)

This chapter describes and evaluates an intermediate online, task-based Chinese course through an analysis of learner performance on the course tasks and assessments, including the performance-based assessments (PBAs) developed specifically for the course. After a brief consideration of online instruction and task-based language teaching (TBLT), the online TBLT course is described in some depth and the technology-mediated pedagogic tasks and associated PBAs are presented. The findings from these tasks and assessments are then reported, followed by a discussion of what the outcomes data revealed about online language instruction, TBLT, and technology-mediated tasks. The goal of this research is to evaluate this particular course in order to provide insights into how best to structure and assess learners during online foreign language classes, offering a model for instruction as well as empirical findings related to the effectiveness of both online and task-based foreign language courses.
Epidemiological Survey of Head and Neck Injuries and Trauma in the United States (2014)

Primary HN injuries commonly present to emergency rooms in the US. The majority of HN injuries are non-life threatening and do not require admission to the hospital or result in death. These data have implications for HN injury surveillance and may be used to risk-stratify patients who present with injuries in the acute care setting.
Separation and purification of G protein from Arabidopsis thaliana (2008)

G protein was purified from the suspended cultured wide-type cell of Arabidopsis thaliana (Col-0) by ultrasonic fragmentation,homogenization,centrifugation,40%～60% saturation Ammonium sulphate sedimentation,gel filtration (Sephadex G-25,Sephadex G-200,Sepharose CL-6B) and DEAE-Sepharose Fast Flow ion exchange chromatographer. The result identified by non-denatured PAGE showed one band in the gel and Western blotting analysis confirmed that the protein was G protein. The target protein after Native-PAGE was collected,and it displayed three bands after SDS-PAGE. The first band was α subunit,and its MW was about 60kDa. The second and third bands which were 45kDa and 35 kDa,were presumed to be the β and γ subunits. The purification method of G protein will facilitate further function investigation of G protein in mutant-type cell of A.thaliana.
Damping factor estimation using spin wave attenuation in permalloy film (2015)

Damping factor of a Permalloy (Py) thin film is estimated by using the magnetostatic spin wave propagation. The attenuation lengths are obtained by the dependence of the transmission intensity on the antenna distance, and decrease with increasing magnetic fields. The relationship between the attenuation length, damping factor, and external magnetic field is derived theoretically, and the damping factor was determined to be 0.0063 by fitting the magnetic field dependence of the attenuation length, using the derived equation. The obtained value is in good agreement with the general value of Py. Thus, this estimation method of the damping factor using spin waves attenuation can be useful tool for ferromagnetic thin films.
Using X-parameters to model diode-based RF power probes (2011)

Summary form only given, as follows. This paper presents an X-parameter model for diode power probes that can be used for calibration purposes. It will be shown that X-parameters can be applied to diode power probes with significant gains in terms of behavior characterization. This first tentative to apply X-parameters is a step further in the calibration of power probes, when they are excited by modulated signals.
Decomposition of the Retrospective Performance Variable in Adaptive Input Estimation (2022)

Retrospective cost input estimation (RCIE) is an adaptive input estimation technique that is based on the minimization of a retrospective performance variable using recursive least squares. In this paper, in order to obtain a better understanding of the underlying mechanism and the performance of RCIE, a decomposition of the retrospective performance variable into the sum of a performance term and a model-matching term is presented. Since this decomposition involves time-varying input-output models, the construction of LTV state space realizations from LTV input-output models as well as the construction of LTV input-output models from LTV state space models are presented. Analysis of the decomposition shows how RCIE avoids convergence to an estimator that is destabilizing or has poor performance. A numerical example is used to illustrate the derived results and observations.
Pasteurella multocida toxin, a potent mitogen, stimulates protein kinase C-dependent and -independent protein phosphorylation in Swiss 3T3 cells. (1990)

Pasteurella multocida toxin, either native or recombinant (rPMT), is an extremely effective mitogen for Swiss 3T3 cells and acts at picomolar concentrations (Rozengurt, E., Higgins, T. E., Chanter, N., Lax, A. J., and Staddon, J. M. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 123-127). Here, we show that similar concentrations of rPMT markedly stimulated the phosphorylation of an acidic 80-kDa protein in [32P]Pi-labeled Swiss 3T3 cells. Co-migration on one- and two-dimensional gels and phosphopeptide analysis indicated that this phosphoprotein was indistinguishable from 80K, a known protein kinase C substrate. In parallel cultures, the stimulation of 80K phosphorylation by rPMT (5-10-fold) was comparable to that induced by bombesin or phorbol dibutyrate (PBt2). However, the increase in phosphorylation by rPMT occurred after a pronounced lag period (1-3 h, depending upon the concentration of rPMT) in contrast to the relatively immediate stimulation by PBt2 or bombesin. Early, but not late, addition of either PMT antiserum or the lysosomotrophic agent methylamine selectively inhibited 80K phosphorylation in response to rPMT. 80K phosphorylation persisted after removal of free toxin and was not inhibited by cycloheximide. It appears that rPMT enters the cells via an endocytotic pathway to initiate and perpetuate events leading to 80K phosphorylation. rPMT, like PBt2, also stimulated the phosphorylation of 87-kDa and 33-kDa proteins in Swiss 3T3 cells. Phosphorylation of the 80K and 87-kDa proteins by rPMT or PBt2 were greatly attenuated in cells depleted of protein kinase C. In contrast, phosphorylation of the 33-kDa protein by rPMT, but not by PBt2, persisted in the absence of protein kinase C. rPMT, like bombesin, caused a translocation of protein kinase C to the cellular particulate fraction. The toxin enhanced the cellular content of diacylglycerol. rPMT also caused a time- and dose-dependent decrease in the binding of 125I-epidermal growth factor to its receptor which was blocked by methylamine and dependent only in part upon the presence of protein kinase C. We conclude that rPMT stimulates protein kinase C-dependent and -independent protein phosphorylation in Swiss 3T3 cells.
Cumulative Adaptation for BLSTM Acoustic Models (2019)

This paper addresses the robust speech recognition problem as an adaptation task. Specifically, we investigate the cumulative application of adaptation methods. A bidirectional Long Short-Term Memory (BLSTM) based neural network, capable of learning temporal relationships and translation invariant representations, is used for robust acoustic modelling. Further, i-vectors were used as an input to the neural network to perform instantaneous speaker and environment adaptation, providing 8\% relative improvement in word error rate on the NIST Hub5 2000 evaluation test set. By enhancing the first-pass i-vector based adaptation with a second-pass adaptation using speaker and environment dependent transformations within the network, a further relative improvement of 5\% in word error rate was achieved. We have reevaluated the features used to estimate i-vectors and their normalization to achieve the best performance in a modern large scale automatic speech recognition system.
Intravesical Bacillus Calmette-Guerin Therapy for Superficial Bladder Cancer: Effect of Bacillus Calmette-Guerin Viability on Treatment Results (1985)

We treated 40 patients with superficial bladder cancer via intravesical bacillus Calmette-Guerin for 1) prophylaxis against tumor recurrence, 2) residual carcinoma or 3) flat carcinoma in situ. A single course of intravesical bacillus Calmette-Guerin therapy was successful in 6 of 11 patients (55 per cent) treated for residual carcinoma and 6 of 12 (50 per cent) treated for carcinoma in situ. Of 17 patients receiving a single course of bacillus Calmette-Guerin for prophylaxis 11 remained free of tumor during short-term followup. A second course of therapy was administered to failures in each treatment category, which resulted in favorable responses in 5 of 6 patients treated for prophylaxis, 2 of 5 treated for residual tumor and 3 of 6 treated for carcinoma in situ. Over-all complete responses were achieved in 16 of 17 patients (94 per cent) treated for prophylaxis, 8 of 11 (73 per cent) for residual carcinoma and 8 of 12 (66 per cent) for carcinoma in situ, with a mean followup from the final treatment of 9.3, 12.3 and 7.9 months, respectively. Favorable results occurred more frequently among patients who exhibited a granulomatous inflammatory response in the bladder and delayed hypersensitivity skin test response to purified protein derivative. Marked variability in viability of bacillus Calmette-Guerin organisms was observed among different lots of bacillus Calmette-Guerin, and a direct relationship was observed between bacillus Calmette-Guerin vaccine viability and therapeutic efficacy. Most patients who failed initial therapy with a low viability lot of bacillus Calmette-Guerin responded favorably to re-treatment with a higher viability lot. The results suggest that the level of viability of each lot of bacillus Calmette-Guerin vaccine should be verified before clinical use.
The synergistic effects of Apatinib combined with cytotoxic chemotherapeutic agents on gastric cancer cells and in a fluorescence imaging gastric cancer xenograft model (2018)

The combination of Apatinib and classical chemotherapy drugs may be an optimal choice for gastric cancer treatment.
Information-theory-based model selection for determining the main vector and period of transmission of Potato virus Y (2011)

Potato virus Y (PVY, genus Potyvirus, family Potyviridae) is transmitted non-persistently by aphids. It causes major losses in potato production (Solanum tuberosum), especially following seed tuber-borne infection of plants. To limit the risk of PVY infection, seed potato production is located preferably in regions where vector pressure is low. The northern-most high-grade seed potato production area (HG zone) of Europe is in Finland. The aim of this study was to determine the incidence of aphid species with documented ability to transmit PVY and to use a modelling approach to determine their relative importance as vectors of PVY in the HG zone of Finland. Winged aphids were caught from six to seven potato fields in each of three growing seasons (2007–09) using yellow pan traps that were examined twice a week. Identification of more than 30 000 individuals indicated that 37% of the aphids belonged to nine species reported to transmit PVY. Incidence of PVY in seed lots was low (0–5.6%) and the seasonal increase of PVY incidence was also low in the potato crops. No potato-colonising aphids were found on the plants in any of the years. The seasonal increase in PVY incidence was modelled using aphid counts in traps, the relative vector efficiencies of the aphids, virus resistance of cultivars, and the initial infection rate of the seed tubers as explanatory variables in generalised linear mixed modelling. Akaike's information criterion was employed to find the best set of explanatory variables for PVY in harvested tubers. Results of this modelling approach showed that the incidence of seed-borne PVY infection and the early-season vector flights are the most important factors contributing to the incidence of PVY in the yield. Compared to models with data from all potential vector species, models containing data from Aphis fabae only showed a better model fit with regard to the incidence of PVY in the harvested tubers. The explanatory power of the models was lost when A. fabae was omitted from the vector data, suggesting that other species play a negligible role as vectors of PVY in the HG zone of Finland. Results can be used to devise appropriate strategies for enhanced control of PVY.
Tobacco Tongs (1900)

Tobacco Tongs Get access Albert Gough Albert Gough 1Holywood, co. Down Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume s9-VI, Issue 145, 6 October 1900, Page 276, https://doi.org/10.1093/nq/s9-VI.145.276b Published: 06 October 1900
Increased Expression of the c-fosProto-Oncogene in Bone from Patients with Fibrous Dysplasia (1995)

Increased expression of the c-fos proto-oncogene, presumably a consequence of increased adenylate cyclase activity, may be important in the pathogenesis of the bone lesions in patients with fibrous dysplasia.
Supplementary Figure 4 from Expansion of CCR8<sup>+</sup> Inflammatory Myeloid Cells in Cancer Patients with Urothelial and Renal Carcinomas (2023)

&lt;p&gt;PDF file - 70K, CCR8+ myeloid cells induce FoxP3 expression in T cells&lt;/p&gt;
General Protocol for the Accurate Prediction of Molecular 13 C/ 1 H NMR Chemical Shifts via Machine Learning Augmented DFT (2020)

An accurate prediction of NMR chemical shifts at affordable computational cost is very important for different types of structural assignments in experimental studies. Density functional theory (DFT) and gauge-including atomic orbital (GIAO) are two of the most popular computational methods for NMR calculation, yet they often fail to resolve ambiguities in structural assignments. Here, we present a new method that uses machine learning (ML) techniques (DFT + ML) that significantly increases the accuracy of <sup>13</sup>C/<sup>1</sup>H NMR chemical shift prediction for a variety of organic molecules. The input of the generalizable DFT + ML model contains two critical parts: one is a vector providing insights into chemical environments, which can be evaluated without knowing the exact geometry of the molecule; the other one is the DFT-calculated isotropic shielding constant. The DFT + ML model was trained with a data set containing 476 <sup>13</sup>C and 270 <sup>1</sup>H experimental chemical shifts. For the DFT methods used here, the root mean square deviations (RMSDs) for the errors between predicted and experimental <sup>13</sup>C/<sup>1</sup>H chemical shifts can be as small as 2.10/0.18 ppm, which is much lower than those from simple DFT (5.54/0.25 ppm), or DFT + linear regression (LR) (4.77/0.23 ppm) approaches. It also has a smaller maximum absolute error than two previously proposed NMR-predicting ML models. The robustness of the DFT + ML model is tested on two classes of organic molecules (TIC10 and hyacinthacines), where the correct isomers were unambiguously assigned to the experimental ones. Overall, the DFT + ML model shows promise for structural assignments in a variety of systems, including stereoisomers, that are often challenging to determine experimentally.
'Practical Considerations for Micro-Stereolithography of Embedded Micro-Channels,' (2013)

R.B. Wicker, A. Ranade, F. Medina, and J. Palmer, 'Practical Considerations for Micro-Stereolithography of Embedded Micro-Channels,' Rapid Prototyping Manufacturing 24 Conference, Rapid Prototyping Association of the Society of Manufacturing Engineers, May 1-13, 24, Hyatt Regency Dearborn, Dearborn, Michigan. Also, SME Technical Paper TP4PUB21 (Dearborn, Mich.: Society of Manufacturing Engineers, 24).
[Studying the tumor growth inhibitory effect of modified GnRH-III-anthracycline bioconjugates in subcutaneous vs. orthotopic models in vivo]. (2015)

Targeted tumor therapy is a perspective procedure to specifically destroy the cancer tissues with eliminating or at least decreasing the side effects of anticancer drugs. For this purpose the drug molecule is attached to a targeting moiety (e.g. peptide hormones) that recognizes tumor specific or overexpressed receptors on cancer cells. The in vitro cytostatic or cytotoxic assays do not give proper information whether the tumor growth inhibitory effect of the conjugate is better than the activity of the free drug. Only in vivo studies are adequate to answer this question. However, the selection of the appropriate tumor model is important to eliminate the false positive results. In our studies a gonadotropin-releasing hormone analog (GnRH-III) was applied as targeting moiety in drug conjugates. The in vivo antitumor activity of these conjugates was investigated on mice bearing subcutaneously or orthotopically szigdeveloped tumors. The subcutaneously implanted tumor model which is isolated from its surroundings may provide false results in tumor growth inhibition. In contrast, the orthotopically developed tumor is a better model representing appropriate anatomical and clinical status of cancer. Therefore, the orthotopical colon cancer developed in our laboratory is a suitable model for the study of the antitumor activity of the conjugates prepared for targeted tumor therapy.
Control Proxy Functions for Sequential Design and Control Optimization (2011)

Abstract Optimal system design of “smart” products requires optimization of both the artifact and its controller. When the artifact and the controller designs are independent, the system solution is straightforward through sequential optimization. When the designs are coupled, combined simultaneous optimization can produce system-optimal results, but presents significant computational and organizational complexity. This paper presents a method that produces results comparable with those found with a simultaneous solution strategy, but with the simplicity of the sequential strategy. The artifact objective function is augmented by a control proxy function (CPF), representing the artifact’s ease of control. The key to successful use of this method is the selection of an appropriate CPF. Four theorems that govern the choice and evaluation of a CPF are given. Each theorem is illustrated using a simple mathematical example. Specific CPFs are then presented for particular problem formulations, and the method is applied to the optimal design and control of a micro-electrical mechanical system actuator.
Experiments With a Diffuser-Augmented Model Wind Turbine (1983)

The initial stages of the experimental development of the diffuser-augmented wind turbine (DAWT) employed various screen meshes to simulate the energy extraction mechanisms of a wind turbine. In this investigation in a 2 × 3 m wind tunnel, a three-bladed constant chord, untwisted turbine model was incorporated into a DAWT model. The objectives were to add real turbine characteristics such as swirl, and centerbodies effects, to the flow. Although this turbine model was not well matched to the diffuser, the model DAWT system increased the power output by more than four times that of the model turbine operating as a conventional wind energy conversion system; more than 3.4 times the power potential of an ideal wind turbine was measured.
Practical Cryptographic Civil GPS Signal Authentication (2012)

A practical technique is proposed to authenticate civil GPS signals. The technique combines cryptographic authentication of the GPS navigation message with signal timing authentication based on statistical hypothesis tests to secure civil GPS receivers against spoofing attacks. The notion of GNSS signal authentication is defined in probabilistic terms. Candidate GPS signal authentication schemes are evaluated in terms of effectiveness and practicality leading to a proposal for incorporating digital signatures into the extensible GPS civil navigation (CNAV) message. The proposal is sufficiently detailed to facilitate near-term implementation of security-hardened civil GPS. Copyright © 2012 Institute of Navigation.
EZH2-mediated loss of miR-622 determines CXCR4 activation in hepatocellular carcinoma (2015)

The CXC chemokine receptor 4 (CXCR4) exerts a variety of functions at different steps of hepatocellular carcinoma (HCC) progression. The molecular mechanisms and therapeutic value of CXCR4 in the development of HCC remain undefined. Here we show that aberrant CXCR4 overexpression is associated with poor prognosis and aggressive characteristics of HCC. Suppression of CXCR4 activity via CXCR4 knockdown, AMD3100 or neutralizing antibody administration inhibits hepatoma cell tumorigenesis in vitro and in vivo. CXCR4 overexpression displays the opposite effects. Using Mir library screening we identify miR-622 as a regulator of CXCR4. Further studies show that miR-622 directly target the 3' untranslated region of CXCR4 and is transcriptionally repressed by EZH2-induced H3K27 trimethylation and promoter methylation. EZH2/miR-622 promotes tumorigenesis through CXCR4. EZH2-mediated loss of miR-622 is found to correlate with CXCR4 overexpression and unfavourable prognosis in HCC patients. This study establishes EZH2/miR-622/CXCR4 as a potential adverse prognostic factor and therapeutic target for HCC patients.