gebhart/patrepeval huggingface dataset:
Federated health information architecture: Enabling healthcare providers and policymakers to use data for decision-making (2017)

Health information systems (HIS) in India, as in most other developing countries, support public health management but fail to enable healthcare providers to use data for delivering quality services. Such a failure is surprising, given that the population healthcare data that the system collects are aggregated from patient records. An important reason for this failure is that the health information architecture (HIA) of the HIS is designed primarily to serve the information needs of policymakers and program managers. India has recognised the architectural gaps in its HIS and proposes to develop an integrated HIA. An enabling HIA that attempts to balance the autonomy of local systems with the requirements of a centralised monitoring agency could meet the diverse information needs of various stakeholders. Given the lack of in-country knowledge and experience in designing such an HIA, this case study was undertaken to analyse HIS in the Bihar state of India and to understand whether it would enable healthcare providers, program managers and policymakers to use data for decision-making. Based on a literature review and data collected from interviews with key informants, this article proposes a federated HIA, which has the potential to improve HIS efficiency; provide flexibility for local innovation; cater to the diverse information needs of healthcare providers, program managers and policymakers; and encourage data-based decision-making.
Aging and Insulin Resistance in a Group of Nonobese Male Volunteers† (1977)

ABSTRACT The relationship of age to insulin resistance was determined in 100 nonobese men whose ages ranged from 22 to 69 years. Seventy of the 100 subjects had normal glucose tolerance, and 30 had chemical diabetes. Insulin resistance was estimated by measuring the steady‐state plasma glucose response to a continuous infusion of insulin, glucose, epinephrine, and propranolol. This approach permitted inhibition of endogenous insulin release, achievement of a comparable steady‐state plasma level of exogenous insulin, and use of the height of the steady‐state plasma glucose response as a direct estimate of insulin resistance. With this experimental method, no correlation was found between age and insulin resistance over the age span of the experimental population. Furthermore, there was no correlation between age and the height of the plasma glucose response to an oral glucose challenge in this population of nonobese, healthy ambulatory men.
Modification of biological objects in water media by CO2-laser radiation (2005)

The modification of biological objects (polysaccharides and cells) by CO2-laser radiation in water added drop by drop into the interaction region is studied theoretically and experimentally. Calculations are performed by using the models describing gas-dynamic and heterogeneous processes caused by absorption of laser radiation by water drops. It is found experimentally that the laser modification of polysaccharides leads to the formation of low-molecular derivatives with immunostimulating properties. A dose of the product of laser activation of the yeast culture Saccharamyces cerevisiae prevented the development of a toxic emphysema in mice and protected them against lethal grippe and also prevented a decrease of survival rate, increased the average life, and prevented the development of metabolic and immune disorders in mice exposed to sublethal gamma-radiation doses.
Targeting Rac and Cdc42 GTPases in Cancer (2018)

Rac and Cdc42 are small GTPases that have been linked to multiple human cancers and are implicated in epithelial to mesenchymal transition, cell-cycle progression, migration/invasion, tumor growth, angiogenesis, and oncogenic transformation. With the exception of the P29S driver mutation in melanoma, Rac and Cdc42 are not generally mutated in cancer, but are overexpressed (gene amplification and mRNA upregulation) or hyperactivated. Rac and Cdc42 are hyperactivated via signaling through oncogenic cell surface receptors, such as growth factor receptors, which converge on the guanine nucleotide exchange factors that regulate their GDP/GTP exchange. Hence, targeting Rac and Cdc42 represents a promising strategy for precise cancer therapy, as well as for inhibition of bypass signaling that promotes resistance to cell surface receptor-targeted therapies. Therefore, an understanding of the regulatory mechanisms of these pivotal signaling intermediates is key for the development of effective inhibitors. In this review, we focus on the role of Rac and Cdc42 in cancer and summarize the regulatory mechanisms, inhibitory efficacy, and the anticancer potential of Rac- and Cdc42-targeting agents. <i>Cancer Res; 78(12); 3101-11. ©2018 AACR</i>.
Acylglycerol structure of genetic varieties of peanut oils of varying atherogenic potential (1981)

Abstract Detailed investigation was made of the triacylglycerol structure of three varieties of peanut oils of varying atherogenic activity. By means of chromatographic and stereospecific analyses, it was shown that all the oils had markedly nonrandom enantiomeric structures with the long chain saturated fatty acids (C 20 −C 24 ) confined exclusively to the sn ‐3‐position, whereas the palmitic and oleic acids were distributed about equally between the sn ‐1‐and sn ‐3‐positions, with the linoleic acid being found preferentially in the sn ‐2‐position. On the basis of detailed studies of the molecular species of the separate sn ‐1,2‐, sn ‐2,3‐ and sn ‐1,3‐diacylglycerol moieties, it was concluded that the fatty acids in the three positions of the glycerol molecule are combined with each other solely on the basis of their relative molar concentrations. As a result, it was possible to calculate the composition of the molecular species of the peanut oil triacylglycerols (including the content of the enantiomers and the reverse isomers) by means of the 1‐random 2‐random 3‐random distribution. In general, the three peanut oils possessed triacylglycerol structures which where closely similar to that derived earlier for a commercial peanut oil of North American origin. Since their oil has exhibited a high degree of atherogenic potential, it was anticipated that the present oils would likewise be atherogenic, which has been confirmed by biological testing. However, there are certain differences in the triacylglycerol structures among these oils, which can be correlated with the variations in their atherogenic activity. The major differences reside in the linoleic/oleic acid ratios in the triacylglycerols, especially in the sn ‐2‐position, and in the proportions in which these acids are combined with the long chain fatty acids. On the basis of the characteristic structures identified in the earlier analyzed atherogenic peanut oil, the peanut oil of South American origin would be judged to possess the greatest atherogenic potential and this has been borne out by biological testing.
Filtering and Tracking for Pedestrian Dead-Reckoning System. (2015)

Localization is all about being lost and found. To those who are my guiding stars, in the vast universe of life. ii ACKNOWLEDGEMENTS Throughout the time that I have been working on this dissertation, like all the matter in life, there were up and down moments. Without help and support from these people, I would never have come this far. I would like to express my sincerest gratitude to everyone that has made this thesis possible. I would like to express my deepest appreciation to both of my co-chairs, Profes-sor Galip Ulsoy and Professor Edwin Olson for their patient and gracious support. This dissertation would have never materialized without their encouragement and guidance. I also would like to thank Professor Johann Borenstein for his guidance and sup-port during my precious time in the Mobile Robotics Laboratory, which was the starting point of my interest in the inertial navigation system and the beginning of
Self‐Organizing Alignment of Carbon Nanotubes in Thermoplastic Polyurethane (2005)

Abstract Summary: A simple compounding technique for the fabrication of polymer nanocomposites with single‐walled carbon nanotubes having exceptional alignment and improved mechanical properties is described. The aligned‐nanotube composite was prepared by dissolving single‐walled carbon nanotubes in a solution of thermoplastic polyurethane and tetrahydrofuran. Solvent‐polymer interactions that induce the orientation of soft chain segments during the swelling and moisture curing stage are believed to serve as a driving force for the macroscopic alignment of the carbon nanotubes. Alignment of single‐walled carbon nanotubes in thermoplastic polyurethane during polar solvent exposure. magnified image Alignment of single‐walled carbon nanotubes in thermoplastic polyurethane during polar solvent exposure.
Pervasive Health Monitoring (2012)

Pervasive health monitoring is the application of non-invasive ambulatory monitoring technologies towards continuous physiologic monitoring. These technologies can be used for the detection of sudden, acute, health problems and the management of chronic disease. For people at risk for specific incidents, such as a heart attack in an individual with heart disease or a fall from an elderly individual, being able to detect a potentially life threatening incident and alerting a care provider can mean the difference between life and death. Likewise, individuals who have chronic health conditions, such as congestive heart failure, can benefit from tracking the progress of their disease. Feedback provided from an ambulatory monitor can be used to help manage the treatment of the disease with the goal of keeping the individual out of the hospital. Currently, people wait until a health problem manifests itself in a way which necessitates a visit to a doctor or a hospital. This type of management is the antithesis of early detection. Often, many conditions have simpler, more effective, and less costly treatments if detected and diagnosed at an early stage. Not only does this result in a better quality of life, but can help to by reducing the costs to the healthcare system. In 2010, U.S. healthcare costs were $2.6 trillion, and it is expected to grow to an incredible $4.6 trillion by 2020. In order to enable a wide range of pervasive monitoring applications, a highly integrated ambulatory physiologic monitor was developed and used in a number of studies. The hardware platform is called The Berkeley Tricorder, and is capable of acquiring a high resolution data from a number of physiologic sensors including an electrocardiograph, an electromyography, a photoplethysmograph, a bioimpedance spectrometer, and an accelerometer. In addition, The Berkeley Tricorder is capable of storing data on an SD memory card, or transmitting it wirelessly over Bluetooth to a local target, or to a remote target using the dial-up-networking Bluetooth profile and a mobile phone. The latest version of the hardware measures 1.4"x1.85". The first chapter explores a number of acute and chronic health conditions to better understand which physiologic monitors are of the most value in an ambulatory system. Next, the physiologic basis of the biosignals are examined, along with the technology which enables their measurement. Based on the methodology used to measure the biosignals, a detailed set of requirements for the implementation of the ambulatory monitor is derived. The requirements are then translated into a physical implementation along with a set of lessons learned along the way. The hardware is then examined to see how it compares to the original design and to quantify its signal quality. Finally, a study used to explore the physiology of stress is using the ambulatory monitor is discussed.
A highly efficient synthesis of cyclaradine and its behaviour towards adenosine deaminase. (1997)

(+)-, (-)-, and (+/-)-Cyclaradines were efficiently synthesized from 2-aza-bicyclo[2.2.1]hept-5-en-3-one (ABH). (+)- and (+/-)-Cyclaradines were deaminated by adenosine deaminase whereas (-)-cyclaradine was not hydrolyzed under the same conditions.
Biodiesel Purification Using Polymeric Nanofiltration Composite Membranes Highly Resistant to Harsh Conditions (2017)

Abstract Biodiesel as alternative for conventional diesel fuel is mainly produced by the catalytic reaction of triglycerides with an alcohol. In this work, the purification of biodiesel was carried out with two lab‐made solvent‐resistant composite nanofiltration membranes of poly(vinylidene difluoride) (PVDF) as support and poly(dimethylsiloxane) as coating layer. Biodiesel was obtained from the esterification of partially refined soy oil with bioethanol (EtOH) and NaOH as catalyst. The best biodiesel purification performance was achieved with the PVDF‐12SI membrane reaching high retention of glycerol, total glycerides, and soap. PVDF‐SI membranes were found to have an excellent stability for biodiesel permeation, achieving a flux recovery ratio of EtOH as high as 0.94 after twenty cycles of use.
Room temperature corrosion behaviour of plastically deformed AISI 304 stainless steel by friction stir welding in neutral and acidified chloride solutions (2022)

Severe plastic deformation of 304L stainless steel plate was carried out by friction stirring under an isothermal tool temperature at 825°C. The friction stirred zone showed extensive grain refinement, high fraction of low angle grain boundaries due to dislocation rearrangement, Σ3 and Σ9 special grain boundaries and discrete Fe–Cr–Mn-rich particles. Electrochemical polarisation measurements were done on the base metal (BM) and friction stir welded (FSW) specimens in the neutral and acidified 3.5% NaCl solutions. The BM showed marginally better pitting resistance in the neutral chloride solution than the FSW because of a larger fraction of special grain boundaries, and larger grain size. Whereas in acidified 3.5% NaCl solution, the FSW showed better corrosion resistance than the BM. The surface film of the FSW had a lower impedance and a lower defect concentration than the BM indicating higher diffusivity of point defects in the FSW.
Preparation and Characterization of Ultrathin Films Layer-by-Layer Self-Assembled from Graphite Oxide Nanoplatelets and Polymers (2000)

Graphite, oxidized by HNO3 and NaClO3 to 25% (GO-25), 42% (GO-42), and 33% (GO-33), has been dispersed to partially exfoliated nanoplatelets and, along with poly(diallyldimethylammonium chloride) (PDDA) and poly(ethylene oxide) (PEO), layer-by-layer self-assembled to ultrathin S−(PDDA/GO)10, S−PDDA/(GO/PEO)10, and S−(PDDA/GO/PEO)10 films (where S is the indium tin oxide- or chromium/gold-coated glass or quartz substrate and GO refers to platelets of oxidized graphite). The GO powders have been characterized by X-ray diffraction prior and by transmission electron microscopy after their dispersions. Thicknesses of each of the successively adsorbed layers were comparatively determined by absorption spectrophotometry, surface plasmon resonance spectroscopy, quartz crystal microbalance, and scanning force microscopy. Good agreements were obtained by these three different techniques.
AN EFFICIENT ALGORITHM FOR STIFFNESS IDENTIFICATION OF TRUSS STRUCTURES THROUGH DISTRIBUTED LOCAL COMPUTATION (2010)

This paper presents an efficient stiffness identification technique for truss structures based on distributed local computation. Sensor nodes on each element are assumed to collect strain data and communicate only with sensors on neighboring elements. This can significantly reduce the energy demand for data transmission and the complexity of transmission protocols, thus enabling a simplified wireless implementation. Element stiffness parameters are identified by simple low order matrix inversion at a local level, which reduces the computational energy, allows for distributed computation and makes parallel data processing possible. The proposed method also permits addressing the problem of missing data or faulty sensors. Numerical examples, with and without missing data, are presented and the element stiffness parameters are accurately identified. The computation efficiency of the proposed method is n2 times higher than previously proposed global damage identification methods.
IDP as an alternative method to reduce the PAPR of DVB-T2 and ATSC 3.0 broadcast systems (2023)

The second generation of digital video broadcasting for terrestrial transmission (DVB-T2) and Advanced Television Systems Committee (ATSC) 3.0 are based on Orthogonal Frequency Division Multiplexing (OFDM) modulation. As known, OFDM has a very high peak-to-average power ratio (PAPR) which affects the system performance in presence of nonlinear power amplification. Many algorithms have been proposed to reduce the PAPR effect on the transmitted signal. The DVB-T2 and ATSC 3.0 standards adopted the technique of tone reservation (TR) which is based on an iterative process where a predefined kernel is applied to reduce a peak power at each iteration. In this paper, the Iterative Dichotomy PAPR reduction method (IDP) is used to reduce the PAPR of both DVB-T2 and ATSC 3.0 standards. The simulation results show that IDP-based PAPR reduction exhibits a gain of 2 dB, in terms of PAPR reduction, compared to TR.
Development of an Ion-Sensitive Solid-State Device for Neurophysiological Measurements (1970)

The development of an ion-sensitive solid-state device is described. The device combines the principles of an MOS transistor and a glass electrode and can be used for measurements of ion activities in electrochemical and biological environments. Some preliminary results are given.
Comparison of Clinical Outcomes of 1- and 2-Level Total Disc Replacement (2015)

1.
The role of prostate-specific membrane antigen PET/computed tomography in the management of prostate cancer patients: could we ask for more? (2022)

For primary prostate cancer staging, PSMA PET/CT seems crucial for primary therapy assessment, being able in some cases to detect lesions outside the surgical template, thus permitting a change in management. Moreover, N+ condition at PSMA has been correlated with a worse biochemical recurrence-free and therapy-free survival. The early detection of PSMA-positive findings in recurrent prostate cancer is associated with a better time to relapse survival. Similarly, for advanced prostate cancer patients, accurate restaging with PSMA imaging is gaining importance for early prediction of response to systemic therapies and to assure the best outcome possible. With regards to theranostics, appropriate selection of patients eligible for 177Lu-PSMA requires PSMA imaging, whereas the role of added FDG-PET for discriminating those with PSMA/FDG discordance needs to be further evaluated.
Linux based virtual networking laboratories for software defined networking (2017)

With the fully mature and a vast number of available virtualization solutions, there is an uptake in creating the opportunityfor remote and/or virtual laboratories to either supplement or fully replace physical networking laboratories. Ourapproach focuses on nodes, rather than environments hosting the nodes. The paper addresses setting up virtuallaboratories made of widely available, general purpose, operating systems based on Linux that act as a network operatingsystem. We discuss several Software Defined Networking solutions, and lay out the configuration setup for virtuallaboratories. We evaluate them by the opportunity they provide in the context of learning and a potential experience. Weconclude with an observation that with an increasing number of Linux based network operating systems, management ofnetwork forwarding devices becomes management of servers, which leads to the unification of the cloud fabric.
Directed Remote Lateral Metalation: Highly Substituted 2‐Naphthols and BINOLs by In Situ Generation of a Directing Group (2018)

A general synthesis of highly substituted 2-naphthols based on a new carbanionic reaction sequence is demonstrated. The reaction exploits the dual nature of lithium bases consisting of consecutive ring opening of readily available coumarins with either LiNEt<sub>2</sub> or LiNiPr<sub>2</sub> into Z-cinnamamides, thus generating a directing group in situ and allowing, by conformational freedom, a lateral directed remote metalation for ring closure to give the aryl 2-naphthols in good to excellent yields. These transformations can be combined to provide a more efficient one-pot process. Mechanistic insight into the remote lateral metalation step, demonstrating the requirement of Z-cinnamamide, is described. Application of this methodology to the synthesis of highly substituted 3,3'-diaryl BINOL ligands is also reported.
Power prediction on broadband channels (2002)

The fading envelope in mobile communications causes rapid variations of the receiving conditions. Fast radio resource allocation and planning require accurate predictions of the changing received power. To form a prediction of the fading power, the individual taps of the channel are predicted and their squared magnitude are summed. The dynamics of the taps can be modeled as subsampled autoregressive or ARMA-processes, leading to the different linear predictors studied. The prediction performance is evaluated on measured mobile radio channels at 45 locations with a bandwidth of 6.4 MHz and Doppler frequencies in the range 30-110 Hz. With the proposed predictors the normalized mean square error for the power prediction is below one percent for prediction ranges up to 2.5 ms, for a majority of the measured channels.
A Novel Type of Hydrogen-Bonded Assemblies Based on the Melamine·Cyanuric Acid Motif (2003)

This paper reports the formation of novel hydrogen-bonded assemblies 1(3).CA obtained upon mixing cyanuric acid (CA) with melamine derivatives 1, in which two of the three possible H-bonding arrays have been blocked. The four components are held together by 9 hydrogen bonds and form a rigid planar structure in which a central CA (three ADA motifs: A = acceptor, D = donor) is hydrogen bonded to three peripheral melamine derivatives (DAD motif). Furthermore, the synthesis and assembly studies are described of hydrogen-bonded assemblies 2-4.CA, comprised of three melamine derivatives that are covalently connected, and CA. The overall thermodynamic stability of assemblies 2-4.CA is superior to 1(3).CA (I(Tm) = 9 vs 3.6). The presence of the 2.CA complex in chloroform was confirmed by (1)H NMR spectroscopy and MALDI-TOF mass spectrometry. Substitution of the trimelamines with chiral or fluorescent groups (R(3)) enabled the study of the assemblies by CD and fluorescence spectroscopy. Titration experiments revealed strongly enhanced stabilities even in the presence of polar solvents, such as THF and CH(3)OH. Depending on the polarity of the solvent, stacking between the planar assembly units was observed.