gebhart/patrepeval huggingface dataset:
The gill arch of the striped bass, Morone saxatilis. III. Morphology of the basal lamina as revealed by various ultrasonic microdissection procedures. (1988)

The ultrastructure of the surface epithelium and the associated basal lamina of the gill arches of the striped bass, Morone saxatilis, were investigated with the scanning electron microscope following complete or partial removal of the epithelium by ultrasonic microdissection. The microdissection procedures employed various combinations of the techniques of aldehyde fixation, treatment with borate, and extensive osmication followed by mild sonication. Generally, aldehyde fixation increases intercellular adhesion, excess osmication increases tissues brittleness, and borate treatment causes extensive tissue dissociation. However, the degree of epithelial removal following sonication of tissues treated with these various procedures varies considerably with specimen structure, shape, proximity to adjacent structures and freedom to vibrate during sonication. The basal lamina exhibits a smooth contour over most of the gill surface with the exception of the short gill rakers where it formed cones within the taste bud cores, and on the respiratory lamellae where it closely mimicked the underlying capillary network.
Nonuniform power generation in polycrystalline thin film photovoltaics (2002)

We consider effects of nonuniformities on thin film photovoltaics where microscopic parameters vary between different local regions. Our experimental data on polycrystalline CdTe/CdS PV cells reveal nonuniformities of different space scales. A related theoretical problem of macroscopic parameters in randomly nonuniform thin film PV cell is solved in the effective medium approximation. The effective open circuit voltage and correlation length in the cell are calculated. The theory predicts hot spots caused by local currents circulating in the system under open circuit conditions.
Online task remapping strategies for fault-tolerant Network-on-Chip multiprocessors (2011)

As CMOS technology scales down into the deep-submicron domain, the aspects of fault tolerance in complex Networks-on-Chip (NoCs) architectures are assuming an increasing relevance. Task remapping is a software based solution for dealing with permanent failures in processing elements in the NoC. In this work, we formulate the optimal task mapping problem for mesh-based NoC multiprocessors with deterministic routing as an integer linear programming (ILP) problem with the objective of minimizing the communication traffic in the system and the total execution time of the application. We find the optimal mappings at design time for all scenarios where single-faults occur in the processing nodes. We propose heuristics for the online task remapping problem and compare their performance with the optimal solutions.
Quantitative effect of target translation on small RNA efficacy reveals a novel mode of interaction (2014)

Small regulatory RNAs (sRNAs) in bacteria regulate many important cellular activities under normal conditions and in response to stress. Many sRNAs bind to the mRNA targets at or near the 5' untranslated region (UTR) resulting in translation inhibition and accelerated degradation. Often the sRNA-binding site is adjacent to or overlapping with the ribosomal binding site (RBS), suggesting a possible interplay between sRNA and ribosome binding. Here we combine quantitative experiments with mathematical modeling to reveal novel features of the interaction between small RNAs and the translation machinery at the 5'UTR of a target mRNA. By measuring the response of a library of reporter targets with varied RBSs, we find that increasing translation rate can lead to increased repression. Quantitative analysis of these data suggests a recruitment model, where bound ribosomes facilitate binding of the sRNA. We experimentally verified predictions of this model for the cell-to-cell variability of target expression. Our findings offer a framework for understanding sRNA silencing in the context of bacterial physiology.
Wild-Type TP53 Inhibits G2-Phase Checkpoint Abrogation and Radiosensitization Induced by PD0166285, a WEE1 Kinase Inhibitor (2002)

The WEE1 protein kinase carries out the inhibitory phosphorylation of CDC2 on tyrosine 15 (Tyr15), which is required for activation of the G(2)-phase checkpoint in response to DNA damage. PD0166285 is a newly identified WEE1 inhibitor and is a potential selective G(2)-phase checkpoint abrogator. To determine the role of TP53 in PD0166285-induced G(2)-phase checkpoint abrogation, human H1299 lung carcinoma cells expressing a temperature-sensitive TP53 were used. Upon exposure to gamma radiation, cells cultured under nonpermissive conditions (TP53 mutant conformation) underwent G(2)-phase arrest. However, under permissive conditions (TP53 wild-type conformation), PD0166285 greatly inhibited the accumulation of cells in G(2) phase. This abrogation was accompanied by a nearly complete blockage of Tyr15 phosphorylation of CDC2, an increased activity of CDC2 kinase, and an enhanced sensitivity to radiation. However, under permissive conditions (TP53 wild-type conformation), PD0166285 neither disrupted the G(2)-phase arrest nor increased cell death. The compound inhibited Tyr15 phosphorylation only partially and did not activate CDC2 kinase activity. To understand the potential mechanism(s) by which TP53 inhibits PD0166285-induced G(2)-phase checkpoint abrogation, two TP53 target proteins, 14-3-3rho and CDKN1A (also known as p21), that are known to be involved in G(2)-phase checkpoint control in other cell models were examined. It was found that 14-3-3rho was not expressed in H1299 cells, and that although CDKN1A did associate with CDC2 to form a complex, the level of CDKN1A associated with CDC2 was not increased in response to radiation or to PD0166285. The level of cyclin B1, required for CDC2 activity, was decreased in the presence of functional TP53. Thus inhibition of PD0166285-induced G(2)-phase checkpoint abrogation by TP53 was achieved at least in part through partial blockage of CDC2 dephosphorylation of Tyr15 and inhibition of cyclin B1 expression.
Mononuclear Iron(II) Dicarbonyls Derived from NNS Ligands – Structural Models Related to a “Pre‐Acyl” Active Site of Mono‐Iron (Hmd) Hydrogenase (2015)

Abstract We report the syntheses and characterization of dicarbonyliron complexes derived from tridentate, ortho ‐substituted Schiff base pyridine/thioether ligands ( R NNS). Metalation reactions of R NNS (R = CH 3 , OCH 3 ) at low temperature (–78 °C) with [Fe(CO) 4 (Br) 2 ] afforded the desired complexes [( R NNS)Fe(CO) 2 Br]Br ( 2 ‐CO Br , 3 ‐CO Br ). Reactions under similar conditions with more sterically demanding ligands [R = quinoline (Q), ClPh] afforded complex salts of the form [( R NNS)Fe(CO) 2 Br][Fe(CO) 3 (Br) 3 ] ( 4 ‐CO Fe and 5 ‐CO Fe , respectively). Alternatively, the metalation of the R NNS ligands (for all R ≠ H) with [Fe(CO) 4 (Br) 2 ] in Et 2 O at room temperature reliably affords the complex species of type [( R NNS)Fe(CO) 2 Br][Fe(CO) 3 (Br) 3 ] ( 2 ‐CO Fe , 3 ‐CO Fe , 5 ‐CO Fe ). The metalation reactions of R NNS at only moderately low temperatures (–20 to 0 °C) result in the loss of CO to form the corresponding trigonal‐bipyramidal iron(II) dibromide species of type [( R NNS)FeBr 2 ] ( 2 ‐Br, 4 ‐Br, 5 ‐Br; μ eff ≈ 5.3 μ B , S = 2). The IR spectrum of each dicarbonyl cation exhibits two ν(CO) stretches at ≈ 2070 and 2030 cm –1 . Low‐temperature 1 H NMR spectroscopy measurements of 2 ‐CO to 5 ‐CO in CD 3 CN (–35 to 5 °C) revealed sharp resonances in the diamagnetic region. Under dark conditions, each dicarbonyl species is relatively stable (&lt;10 % loss of CO, 1–2 h). However, photolysis revealed varying extents of photostability (stability rank: R = OMe &gt; Me ≈ Q &gt; ClPh). An examination of the structural parameters reveals that higher photostabilities correlate with shorter Fe–C(O) bond lengths, which are induced by variation of the ortho substituent of the pyridine ring. DFT calculations along the putative photolysis pathway revealed that the bulky ligand substituent (in 5 ‐CO) destabilizes the monocarbonyl intermediate, and this is a likely explanation for its more rapid rate of CO photodissociation. Relevance to a possible “apo‐active site” of mono‐iron hydrogenase (pre‐acyl formation) is discussed.
Solidification of semicrystalline polymers using a variable interface temperature model (1996)

Solidification of semicrystalline materials often occurs in significantly undercooled melts. The crystal growth process in such melts is convoluted due to the fact that the interface between the solid and liquid domains of the microscopic crystals is at an unknown temperature. However, it is possible to let the temperature of this interface be unspecified and solve the problem with a semianalytical method if the growth velocity is prescribed. Solutions for the temperature profiles in both solid and liquid phases are presented in this work, along with the interface temperature, for phase change processes controlled by the kinetics of crystallization rather than diffusion processes, which is typical for polymers. The method is used for one-dimensional problems in cartesian, cylindrical, and spherical geometries that correspond to commonly found microstructures. It is found that the temperature of the interface is significantly below the equilibrium melting point and a quasi steady-state regime is reached rapidly. Comparison with the classical Neumann's solution shows that the temperature profiles are similar but the position of the interface differs considerably. © 1996 John Wiley & Sons, Inc.
Characterization of the pneumatic behavior of a novel spouted bed apparatus (2008)

Recently the importance of spouted bed technology has significantly increased in the context of drying processes as well as granulation, agglomeration or coating processes. Par-ticulate systems concerning very fine or non spherical particles that are difficult to fluidize, often cannot be treated in conventional fluidized beds. In contrast to those fluidized beds, the spouted bed technology with its specific flow structure offers the opportunity of stable fluidization under controlled conditions. Within this work the fluid dynamics of a novel spouted bed with two adjustable gas inlets is investigated. By analysis of gas fluctuation spectra by means of a fast Fourier transformation algorithm, different operation regimes are identified and depicted graphically. Furthermore, continuum CFD-modeling of the granular solid phase motion by means of an Euler/Euler approach and comparisons with experimental obtained velocity vector fields by means of particle image velocimetry (PIV) measurements will be presented in this work.
3D MPS-MPS coupled FSI solver for simulation of hydroelastic fluid-structure interactions in coastal engineering (2020)

In this paper, a 3D fully Lagrangian meshfree numerical solver for modeling of hydroelastic Fluid-Structure Interaction (FSI) phenomena is presented. Enhanced version of a projection-based MPS (Moving Particle Semi-implicit) fluid model is coupled with an MPS-based Newtonian structure model, resulting in 3D MPS-MPS coupled FSI solver. The Newtonian structure model is founded on conservation equations of linear and angular momenta corresponding to a linear elastic solid. The fluid-structure coupling is conducted by incorporating the FSA (Fluid-Structure Acceleration-based) scheme, where fluid-structure interface boundary conditions are precisely satisfied. The performance of the presented FSI solver is validated by conducting several benchmark test cases with analytical and experimental reference solutions. The solver is proven to possess notable robustness without use of any artificial stabilizers that often lead to unphysical numerical dissipations.
Pyrrolidine dithiocarbamate inhibits immunostimulant-induced tetrahydrobiopterin synthesis in rat vascular smooth muscle (1996)

GTP cyclohydrolase I is the first and rate-limiting enzyme in the synthesis of tetrahydrobiopterin, a cofactor of nitric oxide (NO) synthase. Immunostimulants increase NO and tetrahydrobiopterin synthesis in vascular smooth muscle cells by coinducing NO synthase and GTP cyclohydrolase I gene expression. Given that nuclear factor kappa(B) mediates the induction of NO synthase gene expression by lipopolysaccharide (LPS), the role of nuclear factor kappa(B) in the induction of GTP cyclohydrolase I in LPS-stimulated rat vascular smooth muscle cells was assessed by examining the effects of pyrrolidine dithiocarbamate, an inhibitor of the activation of nuclear factor kappa(B), on the abundance of GTP cyclohydrolase I mRNA and biopterin synthesis. Pyrrolidine dithiocarbamate inhibited both NO and biopterin synthesis induced by LPS in a dose-dependent manner with similar half-maximal inhibitory concentrations, 12 mu M for NO and 17 mu M for biopterin, respectively. At a concentration of 25 mu M, which inhibited NO and biopterin synthesis but caused no cytotoxicity, pyrrolidine dithiocarbamate substantially reduced the LPS-induced increase in the abundance of NO synthase and GTP cyclohydrolase I mRNAs. These results suggest that pyrrolidine dithiocarbamate inhibits LPS-induced NO and biopterin synthesis by inhibiting the expression of NO synthase and GTP cyclohydrolase I genes. Thus, the induction of both genes necessary for cellular NO synthesis in vascular smooth muscle appears to be regulated, at least in part, by a common mechanism: nuclear factor kappa(B) activation.
Use of a Cardiac Output Computer to Measure Earpiece-recorded Dye-dilution Curves, with an Improved Method of Tailpiece Calibration (1967)

The use of large doses of indocyanine green and of a multiple tailpiece sampling procedure is shown to increase both the range and sensitivity of photoelectric earpiece calibration. With these improvements in calibration technique, it becomes feasible to use a cardiac output computer to calculate the curve areas.
Digital Property: Currency of the 21st Century (1998)

Digital Property: Currency of the 21st Century is everyone's guide to seeing information for what it is: a lucrative commodity. Every great product or service begins with an idea, and the value of this invisible - once the province of lawyers specializing in the area - is now front-page news, as Bill Gates and major corporations acquire intellectual property at unheard-of pace. This timely book shows readers that their creative work -whether a photo, a painting, music, data, or a new game - is like money in the bank, and controlling its content means big profits.
P-Chiral, Monodentate Ferrocenyl Phosphines, Novel Ligands for Asymmetric Catalysis (2002)

Eight P-chiral monodentate ferrocenyl phosphines (1a-h) were prepared in high enantiomeric excess (>95% ee in most cases) by way of an ephedrine-based oxazaphospholidine borane complex. Primary alkyl, secondary alkyl, and substituted aromatic substituents were successfully introduced at the phosphorus center, along with ferrocenyl and phenyl groups, generating phosphines of the general structure FcP(Ph)(R) (Fc = ferrocenyl, R = aryl, alkyl). The synthetic route employed provides facile access to a previously undeveloped class of chiral monophosphines. These compounds were evaluated as ligands in asymmetric catalytic reductive coupling of alkynes and aldehydes and were found to provide the desired chiral allylic alcohols with good regioselectivity and ee in many cases and with complete (E)-selectivity (>98:2) in all cases.
Soluble and insoluble signals sculpt osteogenesis in angiogenesis (2010)

The basic tissue engineering paradigm is tissue induction and morphogenesis by combinatorial molecular protocols whereby soluble molecular signals are combined with insoluble signals or substrata.The insoluble signal acts as a three-dimensional scaffold for the initiation of de novo tissue induction and morphogenesis. The osteogenic soluble molecular signals of the transforming growth factor-β(TGF-β) supergene family,the bone morphogenetic/osteogenic proteins(BMPs/OPs) and,uniquely in the non-human primate Papio ursinus(P.ursinus),the three mammalian TGF-βisoforms induce bone formation as a recapitulation of embryonic development.In this paper,I discuss the pleiotropic activity of the BMPs/OPs in the non-human primate P. ursinus,the induction of bone by transitional uroepithelium,and the apparent redundancy of molecular signals initiating bone formation by induction including the three mammalian TGF-βisoforms.Amongst all mammals tested so far,the three mammalian TGF-βisoforms induce endochondral bone formation in the non-human primate P.ursinus only.Bone tissue engineering starts by erect-ing scaffolds of biomimetic biomaterial matrices that mimic the supramolecular assembly of the extracellular matrix of bone.The molecular scaffolding lies at the hearth of all tissue engineering strategies including the induction of bone formation.The novel concept of tissue engineering is the generation of newly formed bone by the implantation of'smart'intelligent biomimetic matrices that per se initiate the ripple-like cascade of bone differentiation by induction without exogenously applied BMPs/OPs of the TGF-βsupergene family.A comprehensive digital iconographic material presents the modified tissue engineering paradigm whereby the induction of bone formation is initiated by intelligent smart biomimetic matrices that per se initiate the induction of bone formation without the exogenous application of the soluble osteogenic molecular signals. The driving force of the intrinsic induction of bone formation by bioactive b
An experimental confirmation of automatic threshold voltage convergence in a flash memory using alternating word-line voltage pulses (1997)

A flash memory using the alternating word-line voltage pulses is experimentally studied. Relations between pulse count and the threshold voltages of the cell are obtained. An automatic threshold voltage convergence was confirmed by the relation, and the threshold voltage is successfully controlled by the word-line pulse voltage. An application to a multi-level flash memory is proposed.
Object Oriented Software Engineering: A Use Case Driven Approach (1992)

Part 1. Introduction 1. System development as an industrial process Introduction A useful analogy System development characteristics Summary 2. The system life cycle Introduction System development as a process of change System development and reuse System development and methodology Objectory Summary 3. What is object-orientation? Introduction Object Class andinstance Polymorphism Inheritance Summary 4. Object-oriented system development Introduction Function/data methods Object-oriented analysis Object-oriented construction Object-oriented testing Summary 5. Object-oriented programming Introduction Objects Classes and instances Inheritance Polymorphism An example Summary Part II. Concepts 6. Architecture Introduction System development is model building Model architecture Requirements model Analysis model The design model The implementation model Test model Summary 7. Analysis Introduction The requirements model The analysis model Summary 8. Construction Introduction The design model Block design Working with construction Summary 9. Real-time specialization Introduction Classification of real-time systems Fundamental issues Analysis Construction Testing and verification Summary 10. Database Specialization Introduction Relational DBMS Object DBMS Discussion Summary 11. Components Introduction What is a component? Use of components Component management Summary 12. Testing Introduction On testing Unit testing Integration testing System testing The testing process Summary Part III. Applications 13. Case study: warehouse management system Introduction to the examples ACME Warehouse Management Inc. The requirements model The analysis model Construction 14. Case study: telecom Introduction Telecommunication switching systems The requirements model The analysis model The design model The implementation model 15. Managing object-oriented software engineering Introduction Project selection and preparation Project development organization Project organization and management Project staffing Software quality assurance Software metrics Summary 16. Other object-oriented methods Introduction A summary of object-oriented methods Object-Oriented Analysis (OOAD/Coad-Yourdon) Object-Oriented Design (OOD/Booch) Hierarchical Object-Oriented Design (HOOD) Object Modeling Technique (OMT) Responsibility-Driven Design Summary Appendix A On the development of Objectory Introduction Objectory as an activity From idea to reality References Index
Supplementary Data S3 from Exploring the Immunogenicity of Noncanonical HLA-I Tumor Ligands Identified through Proteogenomics (2023)

&lt;p&gt;Tumor cell line HLA-I typing and tumor type&lt;/p&gt;
Calcium entry blockers: a review with an attempt at classification (1983)

Journal Article Calcium entry blockers: a review with an attempt at classification Get access P. A. van Zwieten, P. A. van Zwieten Division Pharmacotherapy, Department of Pharmacy, University of Amsterdam1018 T V Amsterdam, The Netherlands Requests for reprints, to Dr P A van Zwieten, Division of Pharmacotherapy, Department of Pharmacy, University of Amsterdam, Plantage Muidergracht 24, 1018 TV Amsterdam, The Netherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar P. B. M. W. M. Timmermans P. B. M. W. M. Timmermans Division Pharmacotherapy, Department of Pharmacy, University of Amsterdam1018 T V Amsterdam, The Netherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar European Heart Journal, Volume 4, Issue suppl_C, May 1983, Pages 1–10, https://doi.org/10.1093/eurheartj/4.suppl_C.1 Published: 01 May 1983
Survey of special needs in physically disabled people: A qualitative research (2011)

After sanction of “the rights of disabled people convention” United Nations Organization have been stressed more on dealing with this group’s needs. Therewith, most of countries in the world have been committed in this field. Therefore with consideration of importance of identifying the needs in disabled people and making policies for them, this study conducted in order to identify the special needs in physically disabled people. This article is a part of a qualitative research with grounded theory method. 15 physically disabled people of Tehran were selected through a purposeful sampling participated in study. The main method for collecting data was semi-structured interview that continued until theoretical saturation of information. Data was analyzed with Strauss &amp; Corbin coding manner or continued comparison and the assessor’s viewpoints method is used for validity promotion of data. Totally, most important domains of special needs in disabled group were: family and relatives, education, movement and transportation, building and places (houses and public places), social participation and occupation, treatment and rehabilitation services, and people’s attitude toward their problems. The results indicated that for promoting social participation and function independency in disabled people, should be emphasis on “equality of opportunities” in society rather than “disability”. Thus, public systems and services should be available equally for all, such as physical environments and places, housing, transport system, educational and vocational opportunities, and socio-cultural life like equipments for sport and amusement. Then, physically disabled people can reach to a life with more quality and same with others.