gebhart/patrepeval huggingface dataset:
Inhibition of the NLRP3 inflammasome prevents ovarian aging (2020)

Inflammation is a hallmark of many processes during aging and reproductive physiology, negatively affecting female fertility. The goal of this study was to evaluate the role of the NLRP3 inflammasome in ovarian aging and female fertility. Age-dependent increased expression of NLRP3 in the ovary was observed in female WT mice during reproductive aging. High expression of NLRP3, caspase 1 and IL-1β was also observed in granulosa cells from patients with primary ovarian insufficiency. Ablation of the NLRP3 inflammasome improved the survival and pregnancy rates in mice, increased hormonal levels of AMH, a biochemical marker of ovarian reserve, and autophagy rates in ovarian tissue. Deficiency of the NLRP3 inflammasome also reduced serum FSH and estradiol levels. Consistent with these results, pharmacological inhibition of NLRP3 using a direct NLRP3 inhibitor, MCC950, improved fertility in female mice to levels comparable to those of Nlrp3 −/− mice. These results suggest that the NLRP3 inflammasome is implicated in the age-dependent loss of female fertility and position this inflammasome as a potential new therapeutic target for the treatment of infertility.
Activation of the CN Ligand in the Gas Phase:  Reaction of Cyanoiron Cations with Allyl Chloride (1996)

Gas-phase cationic complexes Fe(CN)Lx+, obtained from reaction of Fe(CO)n+ with ICN, react with allyl chloride by two successive ligand coupling reactions, involving formation of a N−C bond leading to an isonitrile complex followed by formation of a C−C bond.
A co-design study of low noise amplifier and band-pass filter (2012)

In this paper, the traditional 50Ω interface between the LNA (low-noise amplifier) and the BPF (band-pass filter) is removed, and a co-designed LNA-BPF is presented. The BPF is used to suppress the harmonics and acts as the matching network of LNA. The measured results show, at 2.5GHz, the co-designed LNA-filter achieves a voltage gain of 15.04 dB, a noise figure of 3.9 dB, 3 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rd</sup> harmonic suppression of 66.17dB and P <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">I1dB</sub> of -13dBm. Compared with traditional versions with 50Ω interfaces, the co-designed version obtains a large voltage gain, better P <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">I1dB</sub> and 3 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rd</sup> harmonic suppression and is more compact. Good agreement between the measured and simulated results is achieved.
Structural Chemical Study on Band Gap of Ti1-xAlxN Solid Solution (1987)

A change of band gap for Ti1-xAlxN solid solution was discussed by means of their crystal structures and electronic structures. In the wurtzite phase an indirect transition contributes to the UV absorption process, in contrast to AlN which is known to a direct band gap material. It is found from the XPS analysis that electrons on Ti metal play an important role on energy band for the solid solution. The relation between the band gap change and Auger parameter is also discussed.
Electroencephalography-Guided Anesthetic Administration and Postoperative Delirium (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Microseismic monitoring — The key is integration (2014)

Abstract Microseismic monitoring provides good spatial and temporal information about hydraulic-fracture development in unconventional reservoirs, but it is insufficient by itself to define all the important characteristics of the created fracture system. Other diagnostics can aid in interpretation of fracturing, particularly with respect to volumetric distribution (using microdeformation) and near-wellbore conditions (using fiber optics). The ultimate goal is a better understanding of the effectively producing system through a combination of diagnostics and modeling.
Towards Provably Secure Logic Locking for Hardening Hardware Security (2018)

Logic locking is a promising countermeasure against intellectual property (IP) piracy, counterfeiting, hardware Trojans, reverse engineering, and overbuilding attacks. Yet, various attacks that use a working chip as an oracle have been launched on logic locking, undermining the defense of all existing locking techniques. This paper advances the state-of-the-art in logic locking by developing new countermeasures as well as attacks. We present two logic locking techniques, SARLock and SFLL, that provide quantitative security guarantees against the SAT, removal, and approximate attacks. We validate the effectiveness of proposed techniques by taping-out two silicon chips. We also study the interplay between logic locking and VLSI test, highlighting the security vulnerabilities associated with the test of locked chips. We develop three removal attacks to evaluate the security of existing logic locking techniques.
Long-term efficacy and safety of subcutaneous pasireotide in acromegaly: results from an open-ended, multicenter, Phase II extension study (2013)

Pasireotide has a broader somatostatin receptor binding profile than other somatostatin analogues. A 16-week, Phase II trial showed that pasireotide may be an effective treatment for acromegaly. An extension to this trial assessed the long-term efficacy and safety of pasireotide. This study was an open-label, single-arm, open-ended extension study (primary efficacy and safety evaluated at month 6). Patients could enter the extension if they achieved biochemical control (GH ≤ 2.5 μg/L and normal IGF-1) or showed clinically relevant improvements during the core study. Thirty of the 60 patients who received pasireotide (200-900 μg bid) in the core study entered the extension. At extension month 6, of the 26 evaluable patients, six were biochemically controlled, of whom five had achieved control during the core study. Normal IGF-1 was achieved by 13/26 patients and GH ≤ 2.5 μg/L by 12/26 at month 6. Nine patients received pasireotide for ≥24 months in the extension; three who were biochemically controlled at month 24 had achieved control during the core study. Of 29 patients with MRI data, nine had significant (≥20%) tumor volume reduction during the core study; an additional eight had significant reduction during the extension. The most common adverse events were transient gastrointestinal disturbances; hyperglycemia-related events occurred in 14 patients. Twenty patients had fasting plasma glucose shifted to a higher category during the extension. However, last available glucose measurements were normal for 17 patients. Pasireotide has the potential to be an effective, long-term medical treatment for acromegaly, providing sustained biochemical control and significant reductions in tumor volume.
LoRa Beyond ALOHA: An Investigation of Alternative Random Access Protocols (2020)

In this article, we present a stochastic geometry-based model to investigate alternative medium access choices for LoRaWAN-a widely adopted low-power wide-area network (LPWAN) technology for the Internet-of-Things. LoRaWAN adoption is driven by its simplified network architecture, air interface, and medium access. The physical layer, known as Long Range (LoRa), provides quasi-orthogonal virtual channels through spreading factors (SFs) and time-power capture gains. However, the adopted pure ALOHA access mechanism suffers, in terms of scalability, under the same-channel same-SF transmissions from a large number of devices. In this article, our objective is to explore access mechanisms beyond-ALOHA for LoRaWAN. Using recent results on time- and power-capture effects of LoRa, we develop a unified model for the comparative study of other choices, i.e., slotted ALOHA and carrier-sense multiple access (CSMA). The model includes the necessary design parameters of these access mechanisms, such as guard time and synchronization accuracy for slotted ALOHA, carrier sensing threshold for CSMA. It also accounts for the spatial interaction of devices in annular shaped regions, characteristic of LoRa, for CSMA. The performance metrics derived from the model in terms of coverage probability, channel throughput, and energy efficiency are validated using Monte-Carlo simulations. Our analysis shows that slotted ALOHA indeed has higher reliability than pure ALOHA but at the cost of lower energy efficiency for low device densities. Whereas, CSMA outperforms slotted ALOHA at smaller SFs in terms of reliability and energy efficiency, with its performance degrading to pure ALOHA at higher SFs.
Cannabinoid Receptor Type 2 Ligands: An Analysis of Granted Patents Since 2010 (2021)

The G-protein-coupled cannabinoid receptor type 2 (CB<sub>2</sub>R) is a key element of the endocannabinoid (EC) system. EC/CB<sub>2</sub>R signaling has significant therapeutic potential in major pathologies affecting humans such as allergies, neurodegenerative disorders, inflammation or ocular diseases. CB<sub>2</sub>R agonism exerts anti-inflammatory and tissue protective effects in preclinical animal models of cardiovascular, gastrointestinal, liver, kidney, lung and neurodegenerative disorders. Existing ligands can be subdivided into endocannabinoids, cannabinoid-like and synthetic CB<sub>2</sub>R ligands that possess various degrees of potency on and selectivity against the cannabinoid receptor type 1. This review is an account of granted CB<sub>2</sub>R ligand patents from 2010 up to the present, which were surveyed using Derwent Innovation<sup>®</sup>.
O deficiency in the rutile TiO2(110) surface: Ab initio quantum chemical investigation of the electronic properties (2006)

Abstract The (110) surface of rutile TiO 2 (110) has been modeled using a density functional theory (DFT) plane‐wave pseudo‐potential method (CASTEP). In this study, 6 and 9 atomic‐layer slabs have been examined. The stoichiometric surface converges to a low‐spin solution in both cases with a density of states (DOS) similar to that for the bulk. O deficiencies are introduced by the removal of neutral O atoms thus leaving a neutral model with a surfeit of 2 e − per vacancy. This results in the partial filling of the Ti t 2g conduction band orbitals and a compensatory shift in the Fermi level. The reduced surface converges to a high‐spin solution in all cases, with the excess spin located within the previously unoccupied Ti t 2g orbitals. Removal of the bridging surface O atoms results in an excess spin of 2 electrons per unit cell with approximately one‐half that for removal of in‐plane surface O atoms and subsurface O atoms. The removal of O atoms from the surface leads to an increase of the band gap, with the largest increase due to the removal of in‐plane 3‐fold coordinated surface O atoms, and the smallest one due to the removal of subsurface O atoms. © 2006 Wiley Periodicals, Inc. Int J Quantum Chem, 2006
Classifiers for material discrimination with dual modality x-ray transmission and coherent x-ray diffraction system (2023)

X-ray coherent diffraction-based measurements can provide more specific material information that is complementary to transmission-based material information. With increasing capability of the X-ray coherent diffraction-based systems and recent development of dual modality of X-ray transmission-based and diffraction-based systems, there is a significant potential for improving the overall system threat detection performance for material discrimination. Dual modality systems can yield higher detection probability (Pd) while lowering the probability of false alarm (Pfa), relative to the transmission modality. In this work, we analyze the material discrimination performance for two different machine learning classifiers: support vector machines (SVM) and neural networks (NN), using both simulation and experimental data obtained with a dual-modality X-ray system. Using simulation studies, we demonstrate significant improvement in material discrimination performance afforded by additional complementary information by coherent diffraction for a variety of materials. We further validate these improvements using an experimental dataset collected using real-world objects and materials.
Multidimensional Capillary GC−GC for the Analysis of Complex Samples. 5. Enantiomeric Distribution of Monoterpene Hydrocarbons, Monoterpene Alcohols, and Linalyl Acetate of Bergamot (Citrus bergamia Risso et Poiteau) Oils (1998)

The enantiomeric distribution of β-pinene, sabinene, limonene, linalool, terpinen-4-ol, α-terpineol, and linalyl acetate in cold-pressed, “torchiati”, “ricicli”, “pulizia dischi”, “distilled”, and “bergapten-free” bergamot oils has been determined using a fully automated, multidimensional, double-oven, GC−GC system. This system allows fractions to be multitransferred during the same GC analysis and the use of the two GCs independently when the multitransfer option is not used. The results obtained allowed the characterization of the cold-pressed bergamot oils, to determine the variations of the enantiomeric distribution of some components during the whole production season, and to correlate the enantiomeric ratios with the technology of oil isolation. Keywords: Multidimensional GC−GC; enantioselective gas chromatography; bergamot oils; Citrus bergamia Risso et Poiteau; monoterpene hydrocarbons; monoterpene alcohols; linalyl acetate
Autoimmunity associated with immunotherapy of cancer (2011)

In this age of promise of new therapies for cancer, immunotherapy is emerging as an exciting treatment option for patients. Vaccines and cytokines are being tested extensively in clinical trials, and strategies using monoclonal antibodies and cell transfer are mediating dramatic regression of tumors in patients with certain malignancies. However, although initially advocated as being more specific for cancer and having fewer side effects than conventional therapies, it is becoming increasingly clear that many immunotherapies can lead to immune reactions against normal tissues. Immunotoxicities resulting from treatment can range from relatively minor conditions, such as skin depigmentation, to severe toxicities against crucial organ systems, such as liver, bowel, and lung. Treatment-related toxicity has correlated with better responses in some cases, and it is probable that serious adverse events from immune-mediated reactions will increase in frequency and severity as immunotherapeutic approaches become more effective. This review introduces immunotherapeutic approaches to cancer treatment, provides details of toxicities arising from therapy, and discusses future potential ways to avoid or circumvent these side effects.
Profiling over 1500 Lipids in Induced Lung Sputum and the Implications in Studying Lung Diseases (2015)

Induced lung sputum is a valuable matrix in the study of respiratory diseases. Although the methodology of sputum collection has evolved to a point where it is repeatable and responsive to inflammation, its use in molecular profiling studies is still limited. Here, an in-depth lipid profiling of induced lung sputum using high-resolution liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (LC-Q-TOF MS) is described. An enormous complexity in lipid composition could be revealed. Over 1500 intact lipids, originating from 6 major lipid classes, have been accurately identified in 120 μL of induced sputum. By number and measured intensity, glycerophospholipids represent the largest lipid class, followed by sphingolipids, glycerolipids, fatty acyls, sterol lipids, and prenol lipids. Several prenol lipids, originating from tobacco, could be detected in the lung sputum of smokers. To illustrate the utility of the methodology in studying respiratory diseases, a comparative lipid screening was performed on lung sputum extracts in order to study the effect of Chronic Obstructive Pulmonary Disease (COPD) on the lung barrier lipidome. Results show that sphingolipid expression in induced sputum significantly differs between smokers with and without COPD.
Polyimides. I. Preparation and properties of phosphorus-containing polyimides (1983)

Phosphorus-containing polyimide resins were prepared by reacting benzophenone tetracarboxylic acid dianhydride with (3-aminophenyl) methyl phosphine oxide (DAP). Copolyimides were also prepared using DAP and 4,2′,4′-triaminobenzanilide (TAB) and tris(3-aminophenyl) phosphine oxide (TAP) and pyromellitic dianhydride (PMDA). The homopolymer showed good thermal properties and little degradation below 400°C. The lapshear strengths of these polyimides depended on the backbone structure. Copolymerization improved thermal and mechanical properties. The glass-fabric-reinforced laminate prepared from one of the copolymer resins had a tensile strength of 43,430 psi.
Tim-3 finds its place in the cancer immunotherapy landscape (2020)

The blockade of immune checkpoint receptors has made great strides in the treatment of major cancers, including melanoma, Hodgkin's lymphoma, renal, and lung cancer. However, the success rate of immune checkpoint blockade is still low and some cancers, such as microsatellite-stable colorectal cancer, remain refractory to these treatments. This has prompted investigation into additional checkpoint receptors. T-cell immunoglobulin and mucin domain 3 (Tim-3) is a checkpoint receptor expressed by a wide variety of immune cells as well as leukemic stem cells. Coblockade of Tim-3 and PD-1 can result in reduced tumor progression in preclinical models and can improve antitumor T-cell responses in cancer patients. In this review, we will discuss the basic biology of Tim-3, its role in the tumor microenvironment, and the emerging clinical trial data that point to its future application in the field of immune-oncology.
[The recurrence of a gynecological neoplasm as a solitary thyroid nodule]. (1990)

We present a case of a patient who sought medical assistance because of a single thyroid nodule and had a history of cervix carcinoma and hysterectomy three years earlier not having had any signs of progression of that disease since. The aspiration puncture of the thyroid nodule revealed atypical squamous cells suggestive of metastasis of the gynecological neoplasia. The rareness of the clinical presentation of the thyroid metastasis as well as of the involvement of this gland in the dissemination of cervix neoplasia are discussed, noting on the possible role of radiotherapy on the variation of the progression patterns of the disease. Similarly, the usefulness of cytology obtained by aspirative puncture with a thin needle, in the diagnosis of thyroid nodule is highlighted.
Evolutionary Operation: A Review (1966)

Evolutionary operation, as originally presented by G. E. P. Box in 1957, is now an accepted means of improving the performance of industrial processes. Numerous articles have since been published relating to the successful application of this procedure and they indicate that the technique is one of general industrial importance. It is the purpose of this article to review briefly these applications, thus providing a source of references useful both to those familiar with EVOP and those wishing to examine the potential applicability of the method for an existing process.
Alcohol fermentation of starch by a genetic recombinant yeast having glucoamylase activity (1997)

Alcohol fermentation of starch was investigated using a direct starch fermenting yeast, Saccharomyces cerevisiae SR93, constructed by integrating a glucoamylase-producing gene (STA1) into the chromosome of Saccharomyces cerevisiae SH1089. The glucoamylase was constitutively produced by the recombinant yeast. The ethanol concentration produced by the recombinant yeast was 14.3 g/L which was about 1.5-fold higher than by the conventional mixed culture using an amylolytic microorganism and a fermenting microorganism. About 60% of the starch was converted into ethanol by the recombinant yeast, and the ethanol yield reached its maximum value of 0.48 at the initial starch concentration of 50 g/L. The fed-batch culture, which maintains the starch concentration in the range of 30 to 50 g/L, was used to produce a large amount of ethanol from starch. The amount of ethanol produced in the fed-batch culture increased about 20% compared to the batch culture. (c) 1997 John Wiley & Sons, Inc.
Stretching a molecular wire to tune its conductance (2015)

A scanning tunnelling microscope is used to pull a polythiophene wire from a Au(111) surface while measuring the current traversing the junction. Abrupt current increases measured during the lifting procedure are associated to the detachment of molecular sub-units, in apparent contradiction with the expected exponential decrease of the conductance with wire length. \textit{Ab initio} simulations reproduce the experimental data and demonstrate that this unexpected behavior is due to release of mechanical stress in the wire, paving the way to mechanically gated single-molecule electronic devices.
[Diagnosis and management of allergic rhinitis in the geriatric population]. (2014)

随着我国人口老龄化的快速发展,老年人的卫生健康问题引起了社会广泛关注.衰老可导致机体各系统、各器官发生一系列病理生理改变.人类伴随着年龄老化,免疫功能呈下降趋势,称为“免疫衰老”（immunosenescence）[1-3].这些变化对老年人群变态反应疾病的患病率和严重度也将产生潜在的影响.变应性鼻炎（AR）是特应性个体接触变应原后,以IgE介导的介质释放（组胺、白三烯等）为开端,并由多种免疫活性细胞和细胞因子等参与的鼻黏膜慢性炎性反应疾病.由于老年人免疫应答能力下降,老年AR的免疫学特征及临床表现存在一些特殊性,对此应予以重视.然而,在国内外众多AR临床指南中[4-9],对于老年AR尚缺乏足够的认识,有关诊断和治疗的推荐意见不够完善,有的指南甚至未有涉及.本文围绕老年AR的临床诊治,介绍新近的研究进展及我们的实践经验,供同道们参考.
Do fasting or high caloric drinks affect the physiological uptake of fluorine-18 prostate-specific membrane antigen-1007 in liver and bowel? (2019)

Recently introduced fluorine-18 prostate-specific membrane antigen-1007 (<sup>18</sup>F-PSMA-1007) for imaging prostate cancer has an intense physiologic liver uptake and biliary excretion. The aim of the present study was to evaluate the effect of different dietary conditions on this physiological uptake. Forty consecutive prostate cancer patients were scanned with <sup>18</sup>F-PSMA-1007 positron emission tomography/computed tomography at different dietary conditions. In addition to a blinded read scoring, tracer uptake intensities (standardized uptake values [SUVs]) were measured in the liver and small bowel. There was no significant difference in liver and small-bowel uptake between different patient groups. Wilcoxon signed-rank tests revealed no significant difference of the median mean SUV of the liver or maximum SUV of the horizontal part of the duodenum between different dietary conditions groups. A dietary preparation of patients by fasting or the attempt to clear liver activity by high caloric drinks does not have a significant effect on tracer uptake in the liver or in the small bowel.