gebhart/patrepeval huggingface dataset:
Suppression of AKT Anti-Apoptotic Signaling by a Novel Drug Candidate Results in Growth Arrest and Apoptosis of Hepatocellular Carcinoma Cells (2013)

Hepatocellular carcinoma (HCC) is the third most common cause of cancer fatalities worldwide, with limited treatment options and five year survival rates of between <5 and 15%. To address this medical need, we conducted a screen of a drug-like small molecule library for HCC-selective cytotoxins. We report here the identification of a disubstituted aminothiazole termed HBF-0079, with remarkable selective toxicity for HCC-derived cell lines versus non-HCC liver lines and most other cancer lines. HBF-0079 caused irreversible growth arrest and apoptosis of the HCC lines Huh7, Hep3B, HepaRG as well as the hepatoblastoma line HepG2, with CC₅₀ values from ∼0.7-7.7 µM, while more than 45 µM was needed to achieve CC₅₀ values for the immortalized normal hepatocyte lines THLE-2 and PH5CH. Of the sixty cancer lines from the National Cancer Institute panel, only five exhibited >50% growth inhibition by HBF-0079. In Huh7 cells, HBF-0079 induced cell cycle arrest in G1 and concomitant apoptosis, and its effects were irreversible after removal of the compound. These observations corroborate a loss of AKT phosphorylation at the mTORC2-targeted residue S473, with concurrent loss of phosphorylation of the mTORC1 targets SK6 and 4EBP1 in Huh7 but not PH5CH cells. Finally, growth of Hep3B-derived tumors in a murine xenograft model was significantly repressed by the compound through either systemic or intratumoral administration of formulated HBF-0079. The potential for development of this drug candidate is discussed.
Antithrombotic properties of aspirin and resistance to aspirin: beyond strictly antiplatelet actions (2006)

Aspirin is effective in the prevention of cardiovascular events in high-risk patients. The primary established effect of aspirin on hemostasis is to impair platelet aggregation via inhibition of platelet thromboxane A(2) synthesis, thus reducing thrombus formation on the surface of the damaged arterial wall. Growing evidence also indicates that aspirin exerts additional antithrombotic effects, which appear to some extent unrelated to platelet thromboxane A(2) production. Aspirin can reduce thrombin generation with the subsequent attenuation of thrombin-mediated coagulant reactions such as factor XIII activation. Aspirin also acetylates lysine residues in fibrinogen resulting in increased fibrin clot permeability and enhanced clot lysis as well as directly promoting fibrinolysis with high-dose aspirin. The variable effectiveness of aspirin in terms of clinical outcomes and laboratory findings, which has been termed aspirin resistance, may be related to these additional antithrombotic effects that are altered when associated with common genetic polymorphisms such as the Leu33Pro beta(3)-integrin or Val34Leu factor XIII mutations. However, the clinical relevance of these observations is still unclear. Elucidation of the actual impacts of aspirin other than antiaggregation effects could be important in view of the widespread use of this drug in the prevention of thrombotic manifestations of atherosclerosis.
Subspace-based Estimation Methods Suitable for Downlink DS-CDMA Blind Detectors (2002)

In subspace-based blind linear multiuser detection we may use a subspace tracking algorithm and a blind method for estimating the composite code vector, which is the convolution of the user code and the multipath channel. In this paper we propose two subspace tracking algorithms based on the Power method, one with and the other with operations per update (where is the dimension of sampled received signal and is the rank of the estimated subspace). We also propose a blind method for estimating the composite code vector, which uses the estimated signal subspace bases. This method requires operations per update (considering that is larger than the number of multipath gains). The proposed algorithms are suitable for subspace-based blind linear multiuser detectors for DS-CDMA system downlink. Computer simulations show superior performance of the methods proposed in comparison with other methods presented in the literature.
Development of an Effective Immune Response in Adults With Down Syndrome After Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccination (2022)

Our findings show that DS individuals develop an effective immune response to usual regimes of SARS-CoV-2 vaccination.
Loss of Acid Sensing Ion Channel-1a and Bicarbonate Administration Attenuate the Severity of Traumatic Brain Injury (2013)

Traumatic brain injury (TBI) is a common cause of morbidity and mortality in people of all ages. Following the acute mechanical insult, TBI evolves over the ensuing minutes and days. Understanding the secondary factors that contribute to TBI might suggest therapeutic strategies to reduce the long-term consequences of brain trauma. To assess secondary factors that contribute to TBI, we studied a lateral fluid percussion injury (FPI) model in mice. Following FPI, the brain cortex became acidic, consistent with data from humans following brain trauma. Administering HCO3 (-) after FPI prevented the acidosis and reduced the extent of neurodegeneration. Because acidosis can activate acid sensing ion channels (ASICs), we also studied ASIC1a(-/-) mice and found reduced neurodegeneration after FPI. Both HCO3 (-) administration and loss of ASIC1a also reduced functional deficits caused by FPI. These results suggest that FPI induces cerebral acidosis that activates ASIC channels and contributes to secondary injury in TBI. They also suggest a therapeutic strategy to attenuate the adverse consequences of TBI.
Pulsatile Reperfusion After Cardiac Arrest Improves Neurologic Outcome (1991)

Cardiopulmonary bypass (CPB) using nonpulsatile flow (NPF) is advocated for refractory cardiac arrest. This study examined cerebral outcome after resuscitation with pulsatile flow (PF) versus NPF. Dogs arrested for 12.5 minute were reperfused with NPF (n = 11) using roller pump CPB or PF (n = 11) using mechanical biventricular cardiac massage. Pump flows were similar between groups; however early arterial pressures were greater during PF versus NPF, *p less than 0.05. Circulatory support was weaned at 60 minutes' reperfusion. Neurologic recovery of survivors (n = 16) was significantly better after PF versus NPF, *p = 0.01. The presence of brain lesions on magnetic resonance images did not significantly differ between groups at 7 days. Brain then were removed and regions examined for ischemic changes. Loss of CA1 pyramidal neurons was more severe after NPF versus PF, +p = 0.009. Ischemic changes were more frequent after NPF in the caudate nucleus (+p = 0.009) and watershed regions of the cerebral cortex (+p = 0.062), compared with PF. These results demonstrate that PF improves cerebral resuscitation when treating cardiac arrest with mechanical circulatory support (* = MANOVA with repeated measures, + = categorical data analysis.
Low level detection of microcystin using a plasmonic biosensor (2014)

The presence of cyanobacterial blooms in fresh water has increased due to the accelerated eutrophication of surface water sources. Catastrophic impact to local human and wildlife ecosystems from blooms is linked to the release of hepatotoxins, such as microcystins, into fresh water sources. Therefore, a low-cost, reliable, and highly sensitive method for low concentration detection of microcystins is vitally important to minimize public health risks. In this paper, we report on the first experimental demonstration of microcystins-LR (MC-LR) at low part-per-trillion levels. The demonstrated sensor uses periodically coupled artificial nanostructures to excite a highly sensitive electromagnetic surface wave which directly probes interactions between immobilized antibodies and MC-LR. A layer-by-layer polyelectrolyte adsorption process is utilized to provide highly stable and site-directed immobilization of target antibodies. Steady-state response of the fabricated biosensor confirms detection of MC-LR antigens at low part-per-trillion concentration levels. This demonstration is an important first step towards the development of a lab-on-a-chip sensing systems for in-situ, real-time, distributed environmental monitoring of MC-LR levels in drinking water.
[Construction and biological activities of CTLA4Ig adenovirus vectors]. (2003)

CTLA4Ig adenovirus vectors successfully constructed can infect 293 package cells and secrete CTLA4Ig. The CTLA4Ig protein can inhibit T cell activation. The CTLA4Ig adenovirus vectors can be employed to gene therapy in-vivo, and induce transplantation tolerance.
On the Intriguing Problem of Counting (n+1,n+2)-Core Partitions into Odd\n Parts (2017)

Tewodros Amdeberhan and Armin Straub initiated the study of enumerating\nsubfamilies of the set of (s,t)-core partitions. While the enumeration of\n(n+1,n+2)-core partitions into distinct parts is relatively easy (in fact it\nequals the Fibonacci number F_{n+2}), the enumeration of (n+1,n+2)-core\npartitions into odd parts remains elusive.\n Straub computed the first eleven terms of that sequence, and asked for a\n"formula," or at least a fast way, to compute many terms. While we are unable\nto find a "fast" algorithm, we did manage to find a "faster" algorithm, which\nenabled us to compute 23 terms of this intriguing sequence. We strongly believe\nthat this sequence has an algebraic generating function, since a "sister\nsequence" (see the article), is OEIS sequence A047749 that does have an\nalgebraic generating function. One of us (DZ) is pledging a donation of 100\ndollars to the OEIS, in honor of the first person to generate sufficiently many\nterms to conjecture (and prove non-rigorously) an algebraic equation for the\ngenerating function of this sequence, and another 100 dollars for a rigorous\nproof of that conjecture.\n Finally, we also develop algorithms that find explicit generating functions\nfor other, more tractable, families of (n+1,n+2)-core partitions.\n
<title>Handheld ultrasonic concealed weapon detector</title> (2001)

A handheld, battery-operated prototype of a concealed weapon detector has been built and tested. Designed to detect both metallic and non-metallic weapons, the sensor utilizes focused ultrasound (40 kHz frequency) to remotely detect concealed objects from beyond arm's length out to a range of about 12 feet (4 meters). The detector can be used in prison settings, by officers in the field to allow for stand-off frisking of suspects, and to supplement security at courthouse entrances and other monitored portals. The detector emits an audible alarm (with provision for an earphone jack) as well as a visible light-bar indicator when an object is detected. A high intensity aiming light, with momentary switch, allows the user to accurately determine the location of the concealed object. Current efforts are aimed at increasing the probability of detection, reducing the false-alarm rate, and extending the range of detectability out to 20 feet. Plans for accomplishing these tasks will be presented together with data showing the effective range and probability of detection for the present system.
DETECTING REGIONAL LUNG VOLUME CHANGES DURING HIGH FREQUENCY VENTILATION AND CONVENTIONAL VENTILATION (2004)

SOCIETY OF CRITICAL CARE MEDICINE 34TH CRITICAL CARE CONGRESS PHOENIX, ARIZONA, USA JANUARY 15-19, 2005: Poster: Clinical Science: Pulmonary Disease or Dysfuntion/Mechanical Ventilation/Weaning Pediatrics
Quantum analysis of intensity fluctuations in the nondegenerate parametric oscillator (1988)

A quantum analysis of the intensity fluctuations is given for the nondegenerate parametric oscillator both above and below threshold. Theoretical analysis and experiments by Heidmann, Horowicz, Reynaud, Giacobino, and Fabre [Phys. Rev. Lett. 59, 2555 (1987)] have shown that a noise suppression below the vacuum level is possible in the difference of the intensities of the signal and idler modes. The effect of nonequal cavity decay rates and intracavity losses is shown to modify significantly the fluctuation spectra for the difference in the intensity of the signal and idler beams. The results of exact nonlinear solutions for the internal cavity modes are discussed. We demonstrate that a very sensitive absorption detector may be made by operating the oscillator near threshold.
Enhanced power production from microbial fuel cells with high cell density culture (2016)

Improvement of power production in a microbial fuel cell (MFC) with a high cell density culture strategy was developed. By using high cell density culture, the voltage output and power density output of the MFC were enhanced about 0.6 and 1.6 times compared to the control, respectively. Further analysis showed that riboflavin concentration in the MFC was dramatically increased from 0.1 mg/L to 1.2 mg/L by high cell density culture. Moreover, the biofilm formation on the anode surface was significantly enhanced by this new strategy. The increased accumulation of electron shuttle (riboflavin) as well as enhanced biofilm formation contributed to the improvement in anodic electrochemical activity and these factors were the underlying mechanism for MFC performance improvement by high cell density culture. This work demonstrated that high cell density culture would be a simple and practical strategy for MFC manipulation.
[Having diabetes without knowing it]. (2005)

As part of the activities on the World Day for Diabetes in 2002, nine professors, one nurse who teaches about diabetes and 126 nursing students at University Schools of Nursing in Barcelona, Lleida, Tarragona, Tortosa and Girona, in collaboration with the Association of Diabetics in Catalonia and with the help of the Advisory Council for Diabetes in Catalonia participated in a diabetes screening campaign on the population residing in Catalonia. This campaign studied the prevalence of type two diabetes in a random sample of the Catalan population. This campaign also proposed to raise the awareness among the general population and among nursing students about the important health consequences diabetes has and to increase investigation and social support measures by nurses related to diabetes. This study checked 4083 persons and discovered 77 cases of altered blood-sugar levels among people who did not know they had diabetes. This finding means that there is a 2.2% prevalence of altered blood-sugar levels in the population who are not diagnosed diabetics. Professors and student participants all gave this experience positive marks and the students' degree of satisfaction was very high.
Inhibition of thrombocyte aggregation during extracorporeal lung assist: a case report (2007)

In extracorporeal lung assist, membrane oxygenators are used to improve gas exchange. Accumulations on the membranes of coagulation end products can increase resistance to blood flow and diffusion distance. Thus, functioning of the system can be impaired and, in extreme cases, lead to malfunction which may necessitate change out of the oxygenator. We describe a method that complements conventional continuous heparinisation with the administration of acetylsalicylic acid to inhibit thrombocyte aggregation.
Abstract 9718: Risk Factors for the Development and Progression of Thoracic Aorta Calcification: The Multi-Ethnic Study of Atherosclerosis (MESA) (2012)

Objective: To evaluate risk factors for the incidence and progression of thoracic aorta calcification (TAC) Introduction : Vascular calcification independently predicts cardiovascular disease (CVD) and computed tomography (CT) is a useful tool to evaluate and quantify TAC. Previous TAC progression reports were limited to dialysis and renal transplant patients, This is the first study to evaluate TAC progression in a large multi-ethnic cohort without clinically evident CVD at entry Methods: Non-contrast enhanced cardiac CT (EBCT or MSCT) were obtained in 5886 of the 6814 MESA participants (mean age 62 yrs; 48% male; 40% white, 27% African American (AA), 21% Hispanic, 12% Chinese. Baseline (BL) and follow up (FU) TAC scores were derived Results: 4308 (73%) subjects had no detectable BL TAC. Mean FU duration was 2.4±0.8 yrs, during which 12% developed TAC. The overall incidence rate was 4.8%/yr and was greater with age across gender and ethnic groups,TAC incidence was significantly lower in AA than whites. Regression analyses showed FU time, age, systolic BP, antihypertensives, and smoking were predictors of incident TAC. 1578 (27%) subjects had prevalent TAC at BL scan with a positive association between the averaged annual TAC change and BL age. While the overall median (25 th , 75 th %tiles) change was 32.9 (-1.4,112.2) Agatston units, 38% of study population showed an annual Agatston score progression change of 10-99 and AA showed the lowest median across all ethnic groups; 22.7 (-3,86.8). Regression analyses showed MSCT use, FU time, age, systolic BP, lipid-lowering medication, DM and current smoking were predictors of TAC progression (Tab1) Conclusion: In the MESA cohort, both TAC incidence and progression were significantly associated with traditional CV risk factors. AA had the lowest incidence and median change across ethnic groups, consistent with previous findings for coronary calcification. Further studies are needed to correlate progression with outcome data
CDK4/6 inhibition enhances antitumor efficacy of chemotherapy and immune checkpoint inhibitor combinations in preclinical models and enhances T-cell activation in patients with SCLC receiving chemotherapy (2020)

Transient CDK4/6 inhibition by trilaciclib was sufficient to enhance and prolong the duration of the antitumor response by chemotherapy/ICI combinations, suggesting a role for the transient cell cycle arrest of tumor immune infiltrates in remodeling the tumor microenvironment. These results provide a rationale for combining trilaciclib with chemotherapy/ICI regimens to improve antitumor efficacy in patients with cancer.
Patient-specific models of microglia-mediated engulfment of synapses and neural progenitors (2016)

Engulfment of synapses and neural progenitor cells (NPCs) by microglia is critical for the development and maintenance of proper brain circuitry, and has been implicated in neurodevelopmental as well as neurodegenerative disease etiology. We have developed and validated models of these mechanisms by reprogramming microglia-like cells from peripheral blood mononuclear cells, and combining them with NPCs and neurons derived from induced pluripotent stem cells to create patient-specific cellular models of complement-dependent synaptic pruning and elimination of NPCs. The resulting microglia-like cells express appropriate markers and function as primary human microglia, while patient-matched macrophages differ markedly. As a demonstration of disease-relevant application, we studied the role of C4, recently implicated in schizophrenia, in engulfment of synaptic structures by human microglia. The ability to create complete patient-specific cellular models of critical microglial functions utilizing samples taken during a single clinical visit will extend the ability to model central nervous system disease while facilitating high-throughput screening.
Random Beamformnig in MIMO Systems Exploiting Efficient Multiuser Diversity (2005)

We propose a new random beamforming technique in forward link multiuser MIMO systems that exploits efficient multiuser diversity and spatial multiplexing gain. The common channels are allocated to more than one user simultaneously and multiple antennas at the receivers are used for interference nulling, resulting in higher throughput and reduced average waiting time. We show that the throughput of the proposed scheme outperforms the upper bound of the conventional scheme.
The vanadate garnet Ca2NaCd2V3O12: a single-crystal X-ray diffraction study (2018)

Single crystals of the vanadate garnet Ca<sub>2</sub>NaCd<sub>2</sub>V<sub>3</sub>O<sub>12</sub> (dicalcium sodium dicadmium trivanadate) were synthesized using the floating-zone method and the crystal structure was investigated using single-crystal X-ray diffraction. We considered the effectiveness of substitution of the Y-site cation with reference to previous structural studies of vanadate garnets. The structures of vanadate garnets are subject to geometric constraints similar to those of silicate garnets. These constraints force the tetrahedral-dodecahedral shared edge length in vanadate garnets to become shorter than the unshared dodecahedral edge length, as in ugrandite (uvarovite, grossular and andradite) garnets. However, the vanadate garnet Ca<sub>2</sub>NaCd<sub>2</sub>V<sub>3</sub>O<sub>12</sub> exhibits the normal structural feature, similar to pyralspite (pyrope, almandine and spessartine) garnets, namely that the dodecahedral-dodecahedral shared edge length is shorter than the unshared dodecahedral edge length. With increasing ionic radius of the Y-site cation, the atomic coordinates x, y and z of oxygen adopt values which satisfy Pauling's third rule.
DS-01 * GLUCOCORTICOIDS POTENTLY INDUCE APOPTOSIS IN THE CEREBELLAR EXTERNAL GRANULE LAYER: IMPLICATIONS FOR MEDULLOBLASTOMA TREATMENT (2014)

Premature infants suffering from respiratory dysfunction are often administered glucocorticoids (GCs) to mature the lungs. Unfortunately, neonates exposed to GCs can exhibit neuromotor deficits and selective cerebellar stunting. In order to test the safety of GCs, we administered the synthetic GC dexamethasone to neonatal mouse pups and found it potently increased apoptosis in the external granule layer (EGL) of the cerebellum. The EGL is responsible for producing over 90% of the neurons in the cerebellum, which represents over half the neurons in the entire brain. We subsequently discovered that endogenous GC release, receptors, and enzymatic metabolism is carefully orchestrated to selectively increase stimulation in the EGL as it is naturally eliminated. This suggests the GC system may signal the permanent disappearance of the EGL during development. Unfortunately, EGL neural progenitor cells (NPCs) can transform into medulloblastomas (MBs), the most common malignant brain tumor in children. As a result, the GC system may play a critical role in MB development. Up to 30% of human medulloblastomas are thought to be driven by excessive Hedgehog signaling (a potent EGL mitogen). Consistent with this idea, mice with mutations causing constitutive Hedgehog signaling are also vulnerable to MB formation. Interestingly, excessive Hedgehog signaling is also thought to decrease GC stimulation in the EGL due to selective GC metabolism. Therefore, we used MB prone (Patched) mice to examine if this vulnerability still exists during preneoplastic tumor transformation. We found GC stimulation potently increased apoptotic cell death in preneoplasms. This suggests GCs may both play a role in MB development and have potential as a therapeutic treatment.
Effect of xylitol‐, sucrose‐, and water‐rinses on the composition of human palatine gland secretions (1985)

The chemical composition of stimulated human palatine secretions (HPS) was studied after rinsing with aqueous solutions of sucrose or xylitol, or with water only. Stimulation with water was associated with increased concentration levels of protein. The levels of sialic acids (per mg protein) and the specific arylamidase activities were simultaneously increased, within the physiologic range. In contrast to a previous report, these results indicate that HPS does contain arylaminopeptidases the activity of which is strongly increased by Cl-. The Cl(-)-dependent activity was revealed when using N-L-arginyl-2-naphthylamide as substrate. The filter paper method used is recommended for collecting HPS for chemical analyses. In spite of the use of a relatively effective and versatile stimulation procedure, only one third of the subjects produced detectable HPS. Very poor secretion of HPS should perhaps be considered in subjects wearing total dentures.