gebhart/patrepeval huggingface dataset:
dCubilin/dAMN- mediated protein reabsorption in Drosophila nephrocytes modulates longevity (2021)

Aging is a multifaceted process regulated by multiple cellular pathways, including the proteostasis network. Pharmacological or genetic enhancement of the intracellular proteostasis network extends lifespan and prevents age-related diseases. However, how proteostasis is regulated in different tissues throughout the aging process remains unclear. Here, we show that Drosophila homologs of Cubilin- and Amnionless (dCubilin and dAMN, respectively)-mediated protein reabsorption (CAMPR) from hemolymph insect blood by nephrocytes modulate longevity through regulating proteostasis in muscle and brain tissues. We find that overexpression of dAMN receptor in nephrocytes extends lifespan, whereas nephrocyte-specific dCubilin or dAMN RNAi knockdown shortens lifespan. We also show that CAMPR in nephrocytes regulates proteostasis in hemolymph and improves healthspan. In addition, we show that enhanced CAMPR in nephrocytes slows down the aging process in muscle and brain by maintaining the proteostasis network in these tissues. Altogether, our work has revealed an inter-organ communication network across nephrocytes and muscle/neuronal tissue that is essential for maintaining proteostasis, and to delay senescence in these organs. These findings provide insight into the role of renal protein reabsorption in the aging process via this tele-proteostasis network.
3D thermal-ADI (2003)

Recent studies show that the nonuniform thermal distribution on the substrate and interconnects has impact on the circuit reliability and performance. Hence three-dimensional (3-D) thermal analysis is crucial to analyze these effects. In this paper, we present and develop an efficient 3-D transient thermal simulator based on the alternating direction implicit (ADI) method for large scale temperature estimation problems. Our simulator, 3D Thermal-ADI, not only has a linear runtime and memory requirement, but also is unconditionally stable. Detailed analysis of the 3-D nonhomogeneous cases and boundary conditions for on-chip VLSI applications are introduced and presented. Extensive experimental results show that our algorithm is not only orders of magnitude faster than the traditional thermal simulation algorithms, but is also highly accurate and memory efficient. The temperature profile of steady state can be reached in few iterations. The software is avaiable on the web [1].
Hypomethylation induction in MDS after treatment with decitabine at three different doses (2005)

6546 Background: DNA methyltransferase inhibitors have shown efficacy in patients with MDS. We are conducting a randomized phase II trial of decitabine in MDS at three doses (Group 1: 20 mg/m2 IV daily for 5 days, Group 2: 10 mg/m2 IV daily for 10 days, Group 3: 10 mg/m2 subcutaneously twice a day for 5 days). It remains unclear whether hypomethylation of critical genes and/or global DNA hypomethylation mediate responses to the agent. Methods: Mononuclear cell DNA was obtained from 54 patients at different times (pre-treatment, day 5, 12, and day 26). Using bisulfite/pyrosequencing method, we quantified the methylation status at seven CpG sites in the repetitive element LINE as a surrogate for global methylation, and three CpG sites in the p15 promoter. Results: The overall response rate was 85% (CR 33%, PR 7%, and hematological improvement 44%). CR rate was highest in Group1 (42%) followed by group 3 (29%) and group 2 (25%). Relative LINE hypomethylation (decrease/baseline) averaged 5.5%, 14.0% and 6.9% on days 5, 12, and 26, respectively. Hypomethylation was least pronounced in group 2 (day5; 3.5% vs. 6.3%, p=0.32, Day10; 10.0% vs. 16.3%, p=0.05), which also had the lowest CR rate. There were only 8 patients with no evidence of response, and they had a trend towards lower degree of hypomethylation than responders on day 5 (2.1% vs. 6.1%, p=0.26) and day 10 (10.9% vs. 14.8%, p=0.32). P15 promoter methylation (>10%) was observed in 17/47 patients (36%) before treatment. Significant hypomethylation induction (>20% of baseline) was observed in 12 of these (71%) after decitabine. Baseline p15 methylation trended slightly higher in non-responders than in responders (13.6% vs. 8.2%, p=0.13), but clinical response was observed in patients both with and without baseline p15 methylation, and p15 hypomethylation induction did not correlate with response. Conclusions: Decitabine is very active in MDS. Clinical and laboratory correlates suggest that increasing dose-intensity results in greater hypomethylation and greater clinical efficacy in this disease. P15 promoter methylation at baseline or after therapy was not a predictor of response, and further studies into genes critical for responses to this hypomethylating agent are needed. No significant financial relationships to disclose.
On the construction of polar codes (2011)

We consider the problem of efficiently constructing polar codes over binary memoryless symmetric (BMS) channels. The complexity of designing polar codes via an exact evaluation of the polarized channels to find which ones are “good” appears to be exponential in the block length. In [3], Tal and Vardy show that if instead the evaluation if performed approximately, the construction has only linear complexity. In this paper, we follow this approach and present a framework where the algorithms of [3] and new related algorithms can be analyzed for complexity and accuracy. We provide numerical and analytical results on the efficiency of such algorithms, in particular we show that one can find all the “good” channels (except a vanishing fraction) with almost linear complexity in block-length (except a polylogarithmic factor).
BiSI Micro-Rod Thin Films: Efficient Solar Absorber Electrodes? (2012)

The development of improved solar energy conversion materials is critical to the growth of a sustainable energy infrastructure in the coming years. We report the deposition of polycrystalline BiSI thin films exhibiting promising photoelectrochemical properties on both metal foils and fluorine-doped tin-oxide-coated glass slides using a single-source chemical spray pyrolysis technique. Their strong light absorption in the visible range and well-crystallized layered structure give rise to their excellent photoelectrochemical performance through improved electron-hole generation and separation. The structure and surface composition of the films are dependent on deposition temperature, resulting in dramatic differences in performance over the temperature range studied. These results reveal the potential of n-BiSI as an alternative thin film solar energy conversion material and may stimulate further investigation into V-VI-VII compounds for these applications.
Molecular Dissection of the Human Ubiquitin C Promoter Reveals Heat Shock Element Architectures with Activating and Repressive Functions (2015)

The promoter of the polyubiquitin C gene (UBC) contains putative heat shock elements (HSEs) which are thought to mediate UBC induction upon stress. However, the mapping and the functional characterization of the cis-acting determinants for its up-regulation have not yet been addressed. In this study, the sequence encompassing 916 nucleotides upstream of the transcription start site of the human UBC gene has been dissected by in silico, in vitro and in vivo approaches. The information derived from this analysis was used to study the functional role and the interplay of the identified HSEs in mediating the transcriptional activation of the UBC gene under conditions of proteotoxic stress, induced by the proteasome inhibitor MG132. Here we demonstrate that at least three HSEs, with different configurations, exist in the UBC promoter: two distal, residing within nucleotides -841/-817 and -715/-691, and one proximal to the transcription start site (nt -100/-65). All of them are bound by transcription factors belonging to the heat shock factor (HSF) family, as determined by bandshift, supershift and ChIP analyses. Site-directed mutagenesis of reporter constructs demonstrated that while the distal elements are involved in the up-regulation of UBC in response to proteasome inhibition, the proximal one appears rather to function as negative regulator of the stress-induced transcriptional activity. This is the first evidence that an HSE may exert a negative role on the transcription driven by other HSE motifs on the same gene promoter, highlighting a new level of complexity in the regulation of HSFs and in the control of ubiquitin levels.
The Fast, the furious, and the Frugal (2018)

We’re talking with Saad Bhamla, of the Georgia Tech School of Chemical &amp; Biomolecular Engineering, about his research on very fast motions in small organisms, and the use of frugal approaches to research solutions for global challenges in science education, agriculture, and healthcare.
A clinical roadmap for brain-neural machine interfaces: trainees' perspectives on the 2013 international workshop (2013)

Brain-neural machine interfaces (BNMIs) are systems that allow a user to control an artificial device, such as a computer cursor or a robotic limb, through imagined movements that are measured as neural activity. They provide the potential to restore mobility for those with motor deficiencies caused by stroke, spinal cord injury, or limb amputations. Such systems would have been considered a topic of science fiction a few decades ago but are now being increasingly developed in both research and industry. Workers in this area are charged with fabricating BNMIs that are safe, effective, easy to use, and affordable for clinical populations.
Geochemical Transformations of Sedimentary Sulfur (1995)

The study of chemical transformations of sulfur in sedimentary systems is a frontier research area in geochemistry, and a fuller knowledge of this field is crucial to many geochemical disciplines. Current research on sulfur geochemistry is diverse, spanning topics in low temperature transformations in early diagenesis to the thermal reactions during later diagenesis to catagenesis. It embraces organic, inorganic and biochemical aspects. The present volume provides an interdisciplinary view of recent research on the complex geochemical processes related to sedimentary sulfur transformations based on the 1994 American Chemical Society Symposium. This leading chapter gives an overview of the major geochemical pathways of sedimentary sulfur transformations, emphasizing marine systems.
A Roadmap for Automated Power Line Inspection. Maintenance and Repair (2013)

Electrical power companies usually perform regular visual inspection to check the status of their transmission lines mainly using helicopter equipped with external gimbals housing infrared and ultraviolet camera to detect hot spots and corona discharges. This solution is quite expensive, dangerous for the crew and not very reliable. Focus of this paper is, presenting the state of the art of the most important current projects concerning the two main categories of robots offering a solution of automation, vertical take-off and landing (VTOL) unmanned aerial vehicles (UAVs) and rolling on wires robots (RWR), to create a simple roadmap that can guide researchers and industries in the implementation of a “FULLY AUTOMATED LIVE LINE POWER LINE INSPECTION CONCEPT”: a rigorous live line inspection strategy based on a completely autonomous mobile platform capable of a meaningful payload and a power line data management system including specific tool for image and signal data processing to automatically detect defects or abnormal conditions.
Diagnostic and treatment strategy for small gastrointestinal stromal tumors (2016)

Gastrointestinal stromal tumors (GISTs) are considered to be potentially malignant mesenchymal tumors of the gastrointestinal tract. Clinically relevant GISTs are rare; however, subclinical GISTs (mini-GISTs) (1-2 cm) and pathologic GISTs (micro-GISTs) (<1 cm) are frequently reported. Most mini-GISTs and almost all micro-GISTs of the stomach may exhibit benign clinical behavior, and only mini-GISTs with high-risk features may progress. For this review, a provisional algorithm was used to propose diagnostic and treatment strategies for patients with small GISTs. Because surgery is the only potentially curative treatment, in its application for small GISTs, the principles of sarcoma surgery should be maintained, and cost effectiveness should be considered. Indications for surgery include GISTs measuring ≥2 cm, symptomatic GISTs, and mini-GISTs with high-risk features (irregular borders, cystic spaces, ulceration, echogenic foci, internal heterogeneity, and tumor progression during follow-up); however, a preoperative pathologic diagnosis is infrequently obtained. For small intestinal and colorectal GISTs, surgery is indicated irrespective of size because of their greater malignant potential. Otherwise, mini-GISTs without high-risk features, micro-GISTs, and small submucosal tumors measuring <5 cm without high-risk features may be followed by periodical endoscopic ultrasonography. Although surgical approaches and operative methods are selected according to tumor size, location, growth pattern, and surgical teams, laparoscopic surgery has produced similar oncologic outcomes and is less invasiveness compared with open surgery. After resection, pathologic examination for diagnosis and risk assessment is mandatory, and genotyping is also recommended for high-risk GISTs. Endoscopic resection techniques, although feasible, are not routinely indicated for most mini-GISTs or micro-GISTs. Cancer 2016;122:3110-8. © 2016 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
De-embedding parasitic elements of GaN nanowire metal semiconductor field effect transistors by use of microwave measurements (2011)

We present a de-embedding roadmap for extracting parasitic elements of a nanowire (NW) metal semiconductor field effect transistor (MESFET) from full two-port scattering-parameter measurements in 0.1–25 GHz range. The NW MESFET is integrated in a microwave coplanar waveguide structure. A conventional MESFET circuit model is modified to include capacitors of small value that is non-negligible in NW devices. We follow a step-by-step removal of external elements and an iteration search for optimized model data. The fitted model indicates good agreement with experimental data. This letter reflects a significant step toward full circuit modeling of NW MESFETs under normal operating conditions.
Preparation and Properties of Several Ammonium Uranium(IV) and Ammonium Plutonium(IV) Fluorides (1963)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and Properties of Several Ammonium Uranium(IV) and Ammonium Plutonium(IV) FluoridesR. Benz, R. M. Douglass, F. H. Kruse, and R. A. PennemanCite this: Inorg. Chem. 1963, 2, 4, 799–803Publication Date (Print):August 1, 1963Publication History Published online1 May 2002Published inissue 1 August 1963https://pubs.acs.org/doi/10.1021/ic50008a033https://doi.org/10.1021/ic50008a033research-articleACS PublicationsRequest reuse permissionsArticle Views216Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Além da vigilância e controle: Políticas de regularização e migração boliviana na cidade de La Plata, Argentina (2019)

espanolEl articulo aborda el modo en el que en torno a la implementacion de programas de documentacion para migrantes y a la posibilidad del acceso de las personas a los “papeles” se constituyen procesos politicos que transforman el lugar de los/as arribados/as en la sociedad de destino, focalizando en el caso de la migracion boliviana a la ciudad de La Plata. De esta manera, indagamos en una dinamica en la que agencias consulares e instituciones sociales, sindicales y partidarias locales situaron a los/as migrantes como actores relevantes en el marco de sus objetivos y fueron parte del desarrollo de procesos de movilizacion y elaboracion de demandas novedosas. Se busca sostener, entonces, dos argumentos: en primer lugar que los documentos de identidad –y las politicas destinadas a facilitar su tramitacion- pueden ser objetos con una productividad politica mucho mas compleja que la restringida a la vigilancia y el control. Y, en sintonia, frente a los discursos que senalan que los programas de regularizacion operan como una forma de continuidad de logicas securitarias, apostamos a demostrar que junto con la Ley 25.871 formaron parte inescindible de una dinamica de posicionamiento ciudadano de las personas bolivianas que impacta en diferentes aspectos de sus vidas. EnglishThe article discusses the way in which around the implementation of documentation programs for migrants and the possibility they provide of access to papers political processes that transform the place of those arrived in the target society are constituted, focusing on the case of the Bolivian migration to the city of La Plata. In this way, we investigated a dynamic in which consular agencies and social, labor and support institutions placed migrants as relevant actors within the framework of their objectives and were part of the development of processes of mobilization and elaboration of innovative demands. We seek to hold two arguments: first, that identity documents -and policies designed to facilitate their processing- can be objects with a political productivity that is much more complex than that restricted to surveillance and control. And, in consonance, in front of the speeches that indicate that regularization programs operate as a form of continuity of security logics, we aim to demonstrate that together with Law 25,871 they formed an essential part of a dynamic of citizen positioning of Bolivian people that impacts in different aspects of their lives.
Adults prefer to look at real objects more than photos (2019)

Recent research has found that real objects appear to be processed for longer than visually matched photographs, both in terms of brain activation in adults and looking times in infants. Here we asked whether adults, like infants, would prefer to look at real objects over pictures. A head-fixed eye tracker was used to record gaze locations in adult participants while they viewed a pair of stimuli side by side. Half the stimuli were physically real items while the other half were photos, matched for size and viewpoint, presented on a computer monitor. Paired items were visually similar but not identical (e.g., a real orange could be paired with a photo of a peach or vice versa). Participants spent longer looking at the real object compared to the photo (57% vs. 43% of total looking time). These results suggest similar real-object preferences for adults as infants that may account for a variety of other behavioral and neuroimaging differences. More generally, looking preference techniques appear informative in adults as well as infants and provide a new paradigm for the study of real-object preferences and the factors that drive them.
Hybrid additive and subtractive manufacturing of multi-material objects (2021)

Purpose This study presents a method for fabricating multi-material objects using a hybrid additive and subtractive approach. By hybridizing the material composition in addition to the fabrication process, functional requirements can be met more effectively than through homogenous material parts produced using a single manufacturing process. Development of multi-material objects consisting of dissimilar materials that have been hampered by a lack of a structural interface compatible with in-envelope hybrid additive and subtractive manufacturing. Design/methodology/approach This research presents a novel method for producing multi-material components through in-envelope hybrid additive and subtractive manufacturing. This study attempts to address the absence of a metal-polymer interface by integrating polymer additive manufacturing into a five-axis mill. The ability of the polymer additive system to reproduce overhang geometries is assessed with different levels of cooling. The relationship between structural performance, cooling and material flow rate is evaluated for the deposited carbon fiber reinforced acrylonitrile butadiene styrene. Findings A mechanically interlocking root structure is developed to form an interface between a machined aluminum region and a polymer region of an object. The tensile strength of the metal-polymer object is measured and found to be on the same order of magnitude as the bulk three-dimensional printed polymer. Originality/value By targeting the material properties to the local functional requirements within a part and taking advantage of both additive and subtractive manufacturing processes, this study will enable broader design options and optimization of performance metrics.
Pixels that Sound (2005)

People and animals fuse auditory and visual information to obtain robust perception. A particular benefit of such cross-modal analysis is the ability to localize visual events associated with sound sources. We aim to achieve this using computer-vision aided by a single microphone. Past efforts encountered problems stemming from the huge gap between the dimensions involved and the available data. This has led to solutions suffering from low spatio-temporal resolutions. We present a rigorous analysis of the fundamental problems associated with this task. Then, we present a stable and robust algorithm which overcomes past deficiencies. It grasps dynamic audio-visual events with high spatial resolution, and derives a unique solution. The algorithm effectively detects pixels that are associated with the sound, while filtering out other dynamic pixels. It is based on canonical correlation analysis (CCA), where we remove inherent ill-posedness by exploiting the typical spatial sparsity of audio-visual events. The algorithm is simple and efficient thanks to its reliance on linear programming and is free of user-defined parameters. To quantitatively assess the performance, we devise a localization criterion. The algorithm capabilities were demonstrated in experiments, where it overcame substantial visual distractions and audio noise.