gebhart/patrepeval huggingface dataset:
Chikungunya Fever in the United States: A Fifteen Year Review of Cases (2011)

No locally acquired CHIK cases were identified. However, several viremic travelers returned to states with CHIKV vectors and presented a risk for local transmission. Incomplete and delayed reporting made ArboNET less useful. To minimize the risk of CHIKV spread in the United States, healthcare providers and public health officials should be educated about recognition, diagnosis, and reporting of CHIK cases.
Nucleocytoplasmic Distribution of the Ovalbumin Serpin PI-9 Requires a Nonconventional Nuclear Import Pathway and the Export Factor Crm1 (2001)

Proteinase inhibitor 9 (PI-9) is a human serpin present in the cytoplasm of cytotoxic lymphocytes and epithelial cells. It inhibits the cytotoxic lymphocyte granule proteinase granzyme B (graB) and is thought to protect cytotoxic lymphocytes and bystander cells from graB-mediated apoptosis. Following uptake into cells, graB promotes DNA degradation, rapidly translocating to the nucleus, where it binds a nuclear component. PI-9 should therefore be found in cytotoxic lymphocyte and bystander cell nuclei to ensure complete protection against graB. Here we demonstrate by microscopy and subcellular fractionation experiments that PI-9 is present in the nuclei of human cytotoxic cells, endothelial cells, and epithelial cells. We also show that the related serpins, PI-6, monocyte neutrophil elastase inhibitor (MNEI), PI-8, plasminogen activator inhibitor 2 (PAI-2), and the viral serpin CrmA exhibit similar nucleocytoplasmic distributions. Because these serpins lack classical nuclear localization signals and are small enough to diffuse through nuclear pores, we investigated whether import occurs actively or passively. Large (approximately 70 kDa) chimeric proteins comprising PI-9, PI-6, PI-8, MNEI, or PAI-2 fused to green fluorescent protein (GFP) show similar nucleocytoplasmic distributions to the parent proteins, indicating that nuclear import is active. By contrast, CrmA-GFP is excluded from nuclei, indicating that CrmA is not actively imported. In vitro nuclear transport assays show that PI-9 accumulates at a rate above that of passive diffusion, that it requires cytosolic factors but not ATP, and that it does not bind an intranuclear component. Furthermore, PI-9 is exported from nuclei via a leptomycin B-sensitive pathway, implying involvement of the export factor Crm1p. We conclude that the nucleocytoplasmic distribution of PI-9 and related serpins involves a nonconventional nuclear import pathway and Crm1p.
Figure Eights, Möbius Bands, and More: Conformation and Aromaticity of Porphyrinoids (2011)

The aromatic character of porphyrins, which has significant chemical and biological consequences, can be substantially altered by judicious modifications of the parent ring system. Expansion of the macrocycle, which is achieved by introducing additional subunits, usually increases the so-called free curvature of the ring, leading to larger angular strain. This strain is reduced by a variety of conformational changes, most notably by subunit inversion and p surface twisting. The latter effect creates a particularly convenient access to Möbius aromatic molecules, whose properties, predicted over 40 years ago, are of considerable theoretical importance. The conformational processes occurring in porphyrin analogues are often coupled to other chemical phenomena, and can thus be exploited as a means of constructing functional molecular devices. In this Review, the structural chemistry of porphyrinoids is discussed in the context of their conformational dynamics and p-electron conjugation.
Improvement of body motion measurement using pressure data on Human Body Motion Interface (2011)

This research focuses on the electric wheelchair controlled by Human Body Motion Interface (HBMI). HBMI uses the body motion which is caused by the voluntary motion. From our previous research, it has been confirmed that HBMI, which uses the center of weight on the pressure sensor attached on the backrest has the ability of an interface. However the problem has also remained. The velocities of each wheel have determined based on the error between initial and current position of center of weight. The error increases in the proportion to the inclination of the body. In some cases, the error doesn't increase due to the contact condition between body and backrest, even if the user leans own body. In this case, therefore, the user cannot control the wheelchair arbitrarily in spite of leaning his/her body. This paper shows the improvement to control wheelchair regardless of the amplitude of the error.
[Plasma estrogen levels in postmenopausal women treated with estrogens alone or combined with medroxyprogesterone acetate in the same tablet]. (1992)

A study was carried out with 30 postmenopausal women, treated with conjugated estrogens, alone, or associated with medroxyprogesterone acetate in the same tablet, assaying their plasmatic estrogen levels before and during the treatment, besides its clinical efficacy. There were no significative differences of a given doses in neither of both aspects. The conclusion was that the associated hormonal replacement therapy is a good choice that improves patients compliance with the therapy.
Tissue engineering of the cornea: orthogonal scaffold of magnetically aligned collagen lamellae for corneal stroma reconstruction. (2007)

International audience
Time series analysis for minority game simulations of financial markets (2002)

The minority game (MG) model introduced recently provides promising insights into the understanding of the evolution of prices, indices and rates in the financial markets. In this paper we perform a time series analysis of the model employing tools from statistics, dynamical systems theory and stochastic processes. Using benchmark systems and a financial index for comparison, several conclusions are obtained about the generating mechanism for this kind of evolut ion. The motion is deterministic, driven by occasional random external perturbation. When the interval between two successive perturbations is sufficiently large, one can find low dimensional chaos in this regime. However, the full motion of the MG model is found to be similar to that of the first differences of the SP500 index: stochastic, nonlinear and (unit root) stationary.
High slew rate circuit for high rigidity friction-drive (2020)

Abstract In various fields of research and development in the nanometre regime, a rigid and robust positioning device with nanometic resolution is indispensable. Rapid movement of the piezo-element to induce high shear or propulsive impulse has become one of the widely used mechanisms. The piezo-elements used for this impulsive lateral movement often serve as mechanical support of the moving object, and since they tend to be the narrowest path in the mechanical loop, their rigidity is of great importance in implementing a device with high natural frequency and mechanical stability. The paper presents circuitry to drive such piezo-elements with comparatively larger surface area and higher capacitance with high transient current and slew rate. The circuit could drive a capacitive load of 100 nF, corresponding to 90 cm 2 of the piezo-element, from 0 to 200 V in 1 μ s, with a peak current of up to 100 A.
Speed-of-sound correction for photoacoustic and laser-ultrasound imaging with an integrating cylindrical detector (2015)

A method based on a modified inverse Radon transform is presented to correct photoacoustic and laser-ultrasound section images taken with a cylindrical integrating detector for heterogeneity in the speed of sound. Data for the correction are obtained with a laser ultrasound transmission method, providing two-dimensional maps of the speed of sound distribution. Photoacoustic, laser ultrasound and speed of sound tomography are combined in a single setup using illumination of the sample and several external absorbers with short pulses from a single laser source. The performance of the corrected reconstruction is compared in a simulation and a phantom experiment with a reconstruction using an average, constant sound speed. In this comparison, the reconstruction using the modified inverse Radon transform shows a small but distinguishable improvement.
Encapsulated electroactive molecules (1997)

The role of a dendrimer as an encapsulating shell around small molecules or the dendrimer core itself are briefly outlined. It is shown that encapsulation by a dendrimer reduces the rate of electron transfer to or from a redox‐active moiety incorporated in the core according to the degree of branching around the core. Development of this idea could lead to a molecular switch or an information storage device. The use of the properties of the core in order to obtain information about the shape, internal organization, and environment within a dendrimer is also outlined and an example given.
Focusing on Persons (2021)

In industry, there exist plenty of scenarios where old gray photos need to be automatically colored, such as video sites and archives. In this paper, we present the HistoryNet focusing on historical person's diverse high fidelity clothing colorization based on fine grained semantic understanding and prior. Colorization of historical persons is realistic and practical, however, existing methods do not perform well in the regards. In this paper, a HistoryNet including three parts, namely, classification, fine grained semantic parsing and colorization, is proposed. Classification sub-module supplies classifying of images according to the eras, nationalities and garment types; Parsing sub-network supplies the semantic for person contours, clothing and background in the image to achieve more accurate colorization of clothes and persons and prevent color overflow. In the training process, we integrate classification and semantic parsing features into the coloring generation network to improve colorization. Through the design of classification and parsing subnetwork, the accuracy of image colorization can be improved and the boundary of each part of image can be more clearly. Moreover, we also propose a novel Modern Historical Movies Dataset (MHMD) containing 1,353,166 images and 42 labels of eras, nationalities, and garment types for automatic colorization from 147 historical movies or TV series made in modern time. Various quantitative and qualitative comparisons demonstrate that our method outperforms the state-of-the-art colorization methods, especially on military uniforms, which has correct colors according to the historical literatures.
Fine Particulate Matter (PM2.5) Air Pollution and Immune Status Among Women in the Seattle Area (2011)

Changes in immune status have been suggested as a possible biologic mechanism by which particulate matter (PM) air pollution could lead to adverse health effects. The authors studied associations between ambient PM₂.₅ and immune status among 115 postmenopausal, overweight women in the greater Seattle, Washington, area. The authors evaluated 3-day, 30-day, and 60-day average PM₂.₅ values in relation to inflammation markers (C-reactive protein, serum amyloid A, interleukin-6) and functional assays of cellular immunity (natural killer cell cytotoxicity, T-lymphocyte proliferation) at 3 time points for each woman during 1 year. Three-day averaged PM₂.₅ was inversely associated with anti-CD3-stimulated lymphocyte proliferation. There were no notable associations between the inflammation markers and PM₂.₅. If additional studies confirm our findings, then future health effect assessments for PM₂.₅ should consider changes in cellular immunity as an endpoint that may lead to overt clinical disease.
Development of Universal LED Driver for Low Power Application (2014)

In this work, a universal LED driver is designed based on microcontroller which has the main function to drive different current levels for LEDs power up. Pulse width modulation is applied to vary the output current. Two power LEDs with current rating of 350 mA and 700 mA respectively have been selected as loads and a microcontroller, ATmega328 is programmed through Arduino UNO. Proposed design is simulated and a prototype is fabricated for verification. Both simulation and experimental works have shown good relationship in results justification. Hence this indicates potential development for a large scaled universal LED drivers.
Biphasic Growth of Acetobacter suboxydans on a Glycerol-Limiting Medium (1971)

Dihydroxyacetone was quantitatively produced from glycerol during the primary exponential growth phase and depleted during the secondary exponential phase. Although no growth was detected on the basal medium, growth occurred upon addition of dihydroxyacetone.
Experimental Testing of Mobility Predictions in Averaged Models of Viscous Fingering (1991)

Abstract Averaged empirical models of viscous fingering are frequently used in order to incorporate the effects of miscible viscous instability into coarse grid simulations of processes involving adverse mobility ratio displacements. However, in order to evaluate these models, it is not sufficient to compare the predictions which they make with effluent profiles in 1D displacement experiments since this only tests the transport properties of the model. It is also necessary to compare the predictions of effective mobility of these models with experiment in order to evaluate their use for application in the modelling of multidimensional displacements. The effective mobility can only be assessed directly when the pressure drops are measured along the fingering zone in miscible unstable displacements and such experiments have not previously been reported. In this paper, miscible viscous fingering results have been presented for "2D linear" displacement experiments at mobility ratios of approximately M = 4, 11 and 30. Both effluent profiles (recoveries) and pressure drops along the fingers have been measured and the reproducibility of these in each of the experimental cycles in repacked beds is very good. The effluent and pressure behaviour has been modelled using direct fine grid numerical simulation and a number of averaged models of viscous fingering have been evaluated using the experimental pressure data including the Koval, Todd and Longstaff, Fayers and the Odeh and Cohen models. It has been found that direct numerical simulation reproduces both the experimental effluent concentration profiles and the observed pressure drop behaviour very well. However, of the averaged model approaches, the Todd and Longstaff and an equivalent mixing model give the most satisfactory agreement with the observed effective in situ mobilities (pressure drops) in the fingering zone. Both the original Koval model and the modification proposed by Odeh and Cohen do not give good agreement with experimental pressure drop measurements. The approach of Fayers also has some shortcomings in that it predicts a viscosity in the finger zone that is too low (i.e. effective mobility is too high) due to the presence of an unphysical shock front behaviour which this model exhibits.
ChemInform Abstract: ARYLIERUNG DURCH AROMATISCHE NITROVERBINDUNGEN BEI HOHEN TEMPERATUREN 8. MITT. RK. VON NITROBENZOL UND NITROBENZOL‐D5 MIT CYCLOHEXAN BEI 600 GRAD (1970)

Abstract Nitrobenzol (I) wurde bei 600°C über eine Bildung von Phenylradikalen (II) etc. mit Cyclohexan (III) umgesetzt.
Abstract 5961: Inhibition of AURKA destabilizes glioblastoma primary cilia and sensitizes cells to tumor treating fields (TTFields) in vitro and ex vivo (2023)

Abstract Tumor Treating Fields (TTFields) can prolong survival of patients with glioblastoma (GBM), but GBM cells still escape this therapy requiring an urgent need for new or adjunct treatments. Recently we reported that TTFields disrupt primary cilia on GBM cells which lowers resistance to standard of care temozolomide chemotherapy. Here we asked if concomitant or sequential treatment of TTFields with other agents that interfere with GBM ciliogenesis enhance TTFields efficacy. Aurora Kinase A (AURKA) plays both a role in promoting cilia disassembly and regulating GBM growth in xenograft models. We found that within 24hr of treatment with the AURKA inhibitor, Alisertib, there was surprising and significant decrease in GBM cilia frequency across multiple GBM patient derived lines. However, similar Alisertib treatment did not affect neuronal or glial cilia frequencies in mixed primary cell cultures from mouse forebrain. Notably, overnight treatment of patient GBM biopsy ex vivo with Alisertib also resulted in reduced cilia frequency within the tumor tissue. Next, we co- or sequentially treated several different GBM patient cell lines with 24hr of 200kHz TTFields together with or followed by 250nM or 1µM Alisertib and examined the subsequent expansion of cells in vitro. We observed a significant synergistic reduction in cell proliferation compared to either treatment alone. However, this synergistic effect does not appear to be cilia-dependent as dual treatment reduction in proliferation was still observed in cell lines lacking different key cilia genes or in GBM cells that naturally lack cilia. Considering Alisertib crosses the blood brain barrier and inhibits intracranial growth of tumors, our data warrant investigation of whether concomitant or sequential treatment of TTFields and Alisertib in vivo can further prolong survival. Citation Format: Jia Tian, Julianne Mallinger, Ping Shi, Dahao Ling, Loic Deleyrolle, Min Lin, Habibeh Khoshbouei, Matthew Sarkisian. Inhibition of AURKA destabilizes glioblastoma primary cilia and sensitizes cells to tumor treating fields (TTFields) in vitro and ex vivo [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 5961.
Novel brain computed tomography perfusion for cerebral malperfusion secondary to acute type A aortic dissection (2022)

CTP was able to detect irreversible ischaemic core, guide critical decisions in preoperative patients and aid in determining the blood pressure augmentation for postoperative management focusing on residual brain ischaemia.
Effect of intense THz pulses on expression of genes associated with skin cancer and inflammatory skin conditions (2014)

The growing experimental evidence suggests that broadband, picosecond-duration THz pulses may influence biological systems and functions. While the mechanisms by which THz pulse-induced biological effects are not yet known, experiments using <i>in vitro</i> cell cultures, tissue models, as well as recent <i>in vivo</i> studies have demonstrated that THz pulses can elicit cellular and molecular changes in exposed cells and tissues in the absence of thermal effects. Recently, we demonstrated that intense, picosecond THz pulses induce phosphorylation of H2AX, indicative of DNA damage, and at the same time activate DNA damage response in human skin tissues. We also find that intense THz pulses have a profound impact on global gene expression in human skin. Many of the affected genes have important functions in epidermal differentiation and have been implicated in skin cancer and inflammatory skin conditions. The observed THzinduced changes in expression of these genes are in many cases opposite to disease-related changes, suggesting possible therapeutic applications of intense THz pulses.
Panel Warpage and Die Shift Simulation and Characterization of Fan-Out Panel-Level Packaging (2020)

Fan-out panel level packaging (FO-PLP) technology using mold first method and large glass carrier (550mm × 650mm) is demonstrated in this paper. Panel warpage and die shift are investigated through finite element analysis (FEA) and Taguchi statistic method. Critical factors affecting panel warpage at different processes are identified. Solution for reducing panel warpage and die shift are provided in terms of structure design and process optimization and suitable material selection. The effect of gravity on panel warpage is also simulated. Modelling gravity reduces panel warpage significantly when the panel is sitting on the table, but warpage increases when the panel is supported along edge, which arises thin panel handling issue and should be carefully considered.
Backstepping observer based-control for an anti-damped boundary wave PDE in presence of in-domain viscous damping (2016)

This paper presents a backstepping control design for a one-dimensional wave PDE with in-domain viscous damping, subject to a dynamical anti-damped boundary condition. Its main contribution is the design of an observer-based control law which stabilizes the wave PDE velocity, using only boundary mesurements. Numerical simulations on an oil-inspired example show the relevance of our result and illustrate the merits of this control design.
Size-dependent upconversion luminescence and temperature sensing behavior of spherical Gd2O3:Yb3+/Er3+ phosphor (2015)

In this paper, we found that sensing sensitivity increases with decreasing the particle size, which was confirmed by the Judd–Ofelt theory.
Supplementary Figure 2 from Potent Anti-leukemia Activities of Chimeric Antigen Receptor–Modified T Cells against CD19 in Chinese Patients with Relapsed/Refractory Acute Lymphocytic Leukemia (2023)

&lt;p&gt;A, A representative diagram of the transduction efficiency evaluation of CART19s 5 days after lentivirus infection. B, Specific target cell lysis by CART19s. T cells or CART19s were co-cultured with K562-RFP cells or CD19-RFP-K562 cells at the indicated E:T ratio for overnight co-culture (24 hours). C, IFN-Î³ secretion measurements in supernatants in T cells or CART19 cells co-cultured with K562-RFP cells or CD19-RFP-K562 cells at the indicated E:T ratios for 24 hours.&lt;/p&gt;