gebhart/patrepeval huggingface dataset:
Effects of Nonpeptide and Selective V1 and V2 Antagonists on Blood Pressure Short-Term Variability in Spontaneously Hypertensive Rats (2004)

Effects of V(1) (OPC-21268) and V(2) (OPC-31260) vasopressin antagonists on blood pressure (BP) short-term variability were investigated in adult spontaneously hypertensive rats (SHR) under basal conditions and after the stimulation of vasopressin release by hemorrhage. BP was recorded intra-arterially and sampled at 20 Hz to be analyzed on a personal computer. BP time spectra were calculated on 30 stationary overlapping 2048 point-time series. Spectral power was estimated in total (0.00976 - 3 Hz), very low frequency (VLF: 0.00976 - 0.195 Hz), low frequency (LF: 0.195 - 0.605 Hz), and high frequency (HF: 0.8 - 3 Hz) regions. Under basal conditions a V(1) antagonist (5 mg/kg, i.v.) decreased BP without affecting BP variability, while combined (V(1) + V(2)) blockade or V(2) blockade (1 mg/kg, i.v.) alone did not affect cardiovascular parameters. Mild hemorrhage (5 ml/kg per min) increased HF-BP variability, while moderate (10 ml/kg per min) and massive (15 ml/kg per min) hemorrhage did not affect it. In V(1), but not V(2), antagonist pre-treated SHR HF-BP increased significantly after moderate and massive hemorrhage. V(1) or V(2) antagonist pre-treatment also enhanced VLF-BP variability during massive hemorrhage. Moreover V(1) blockade prevented hemorrhage-induced bradycardia, while V(2) blockade potentiated it. It follows that in adult SHR, vasopressin buffers BP oscillations in HF and VLF frequency domains only in hypovolaemic conditions and that the modulation of the autonomic adjustment of the HR to hemorrhage by vasopressin is preserved.
Peptides incorporating electrophilic glutamine analogues as potential transglutaminase inhibitors (1990)

Conference Article| December 01 1990 Peptides incorporating electrophilic glutamine analogues as potential transglutaminase inhibitors PAUL M. DOYLE; PAUL M. DOYLE *Department of Medicinal Chemistry, Wellcome Research Laboratories, Langley Court, Beckenham, Kent BR3 3BS, U.K. Search for other works by this author on: This Site PubMed Google Scholar C. JOHN HARRIS; C. JOHN HARRIS *Department of Medicinal Chemistry, Wellcome Research Laboratories, Langley Court, Beckenham, Kent BR3 3BS, U.K. Search for other works by this author on: This Site PubMed Google Scholar KEITH R. CARTER; KEITH R. CARTER *Department of Medicinal Chemistry, Wellcome Research Laboratories, Langley Court, Beckenham, Kent BR3 3BS, U.K. Search for other works by this author on: This Site PubMed Google Scholar DEAN S. A. SIMPKIN; DEAN S. A. SIMPKIN *Department of Medicinal Chemistry, Wellcome Research Laboratories, Langley Court, Beckenham, Kent BR3 3BS, U.K. Search for other works by this author on: This Site PubMed Google Scholar PAUL BAILEY-SMITH; PAUL BAILEY-SMITH *Department of Medicinal Chemistry, Wellcome Research Laboratories, Langley Court, Beckenham, Kent BR3 3BS, U.K. Search for other works by this author on: This Site PubMed Google Scholar DAVID STONE; DAVID STONE †Department of Biochemical Science, Wellcome Research Laboratories, Langley Court, Beckenham, Kent BR3 3BS, U.K. Search for other works by this author on: This Site PubMed Google Scholar LINDA RUSSEL; LINDA RUSSEL †Department of Biochemical Science, Wellcome Research Laboratories, Langley Court, Beckenham, Kent BR3 3BS, U.K. Search for other works by this author on: This Site PubMed Google Scholar GEOFFREY J. BLACKWELL GEOFFREY J. BLACKWELL †Department of Biochemical Science, Wellcome Research Laboratories, Langley Court, Beckenham, Kent BR3 3BS, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1990) 18 (6): 1318–1320. https://doi.org/10.1042/bst0181318 Article history Received: May 01 1990 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation PAUL M. DOYLE, C. JOHN HARRIS, KEITH R. CARTER, DEAN S. A. SIMPKIN, PAUL BAILEY-SMITH, DAVID STONE, LINDA RUSSEL, GEOFFREY J. BLACKWELL; Peptides incorporating electrophilic glutamine analogues as potential transglutaminase inhibitors. Biochem Soc Trans 1 December 1990; 18 (6): 1318–1320. doi: https://doi.org/10.1042/bst0181318 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1990 Biochemical Society1990 Article PDF first page preview Close Modal You do not currently have access to this content.
Antidepressant Treatment Patterns in a Novel Methadone Maintenance Clinic Targeting Young Adults (2006)

This observational study examined the antidepressant treatment patterns of a novel New York City methadone maintenance treatment program (MMTP), founded for the treatment of adolescents and now targeting young adults and older patients with special problems. The goal of the study was to investigate demographic or clinical characteristics that were associated with prescribing patterns, as well as whether antidepressant use was associated with sobriety. The method of data collection was a thorough chart review. Antidepressant treatment was significantly associated with gender, education, marital status, and relapse. However, after controlling for demographic and clinical characteristics, antidepressant treatment was not significantly associated with a reduction in relapse risk. Further research is needed to explore these relationships, as well as their generalizability to adult methadone clinics, and to examine the underlying factors that lead to similarities and distinctions in antidepressant prescribing practices between various types of clinics (i.e., general outpatient vs. methadone maintenance).
Introduction: Tilling the Fields of Postcolonial Literature (2016)

The title of this volume embraces the idea of ‘new soundings’ in its double meanings: ‘soundings’ in the sense of exploratory fathoming and plumbing of the ocean depths, and ‘soundings’ in the contemporary sense of sonar registrations of the seabed, made in order to hear and notate the invisible, inaudible life and activity below the surface. The metaphoric connotations of depth charges in the former usage point to the various forms of mapping, of the discoveries and expansions associated with the opening up of what were once conceived as distant lands, as well as the hazards and betrayals entailed in such colonizing. ‘Soundings’, when used in the sense of registering sound shapes and effects, implies metaphorically those acts of communication, whereby the newly charted, discovered worlds transmit their cultures, heritage and voices, receiving in return the mixed messages of those who discover and colonise. For such processes of settlement and entrenchment are fraught with contestation, involving new contact zones, encounters with Indigenous peoples, recognition of racial and ethnic differences and ideological reassessment of the nature of civilisation. The subtitle’s reference to ‘contours’ invokes the new cultural frames that emerge from such forms of contact, and the organising, reshaping and syncretising of what Homi Bhabha has called the ‘spaces between’ cultures that contact/collision provokes. Such new cultural landscaping can be found in the critical and creative writing of the last half century that embodies as well as engages with issues of the postcolonial. The subtitle also refers to the critical essays, poems and stories collected in this volume, all of which are associated with the discipline of postcolonial studies, and might be seen as products of this broad field. Just as the critical contours seek to debate and give wider visibility to postcolonialism’s major contestations, so the book’s creative contours showcase some of the movement’s significant themes and imaginative configurations.
Effect of Ionic Strength on the Kinetics of Trypsin and Alpha Chymotrypsin (1961)

The kinetic effects resulting from changes in the medium ionic strength on reactions involving trypsin or alpha-chymotrypsin are different. The reaction rate increases continuously as the ionic strength increases with alpha-chymotrypsin. With trypsin, the rate increases at low ionic strengths but as the ionic strength further increases a gradual inhibitory effect is observed. The effects produced by different salts of various valence types (from uni-univalent to uni-trivalent or tri-univalent) are essentially the same, and they are a function of the square root of the ionic strength. The quantitative differences among the various salts may be accounted for on the basis of individual properties of the ions, such as the size of the hydrated ion, "association," etc. The effects of salts on the enzymic reactions described herein are amenable to the same electrostatic treatment applicable to non-enzymatic reactions. By applying Brönsted's basic kinetic concepts and the Debye-Hückel law of electrolyte activity, it appears that the salt effects are mainly due to changes in the dissociation of ionizable groups. This appears to be a general method for analyzing the effect of inorganic ions on enzymic reactions.
Speciation Analysis of Radionuclides in the Environment - NSK-B SPECIATION project report 2009 (2009)

The second stage of the NKS-B project SPECIATION was complemented in 2008-2009, which mainly focus on three aspects: (1) Further improvement and development of methods for speciation analysis of radionuclides; (2) Investigation of speciation of some radionuclides in the environment (water, sediments, particles); and (3) Intercomparison excise for speciation analysis of radionuclides in soil and sediment. This report summarizes the work completed in the project partners' laboratories. Method developments include: Development of an rapid and in-suit separation method for the speciation analysis of 129I in seawater samples; Development of a simple method for the speciation analysis of 129I in fresh water and seawater samples; Development of an on-line HPLC-ICP-MS method for the direct speciation analysis of 127I in water and leachate samples; Speciation of radionuclides in water includes: Speciation of 129I and 127I in time-series precipitation samples collected in Denmark 2001-2006 and its application for the investigation of geochemistry and atmospheric chemistry of iodine, Speciation of radionuclides in Ob and Yenisey Rivers, and Speciation of 129I and 127I in Lake Heimdalen water. Speciation of radionuclides in soils and sediments includes: Sequential extraction of radionuclides in sediments and of trace elements in soil samples. Sequential extraction of radionuclides in aerosols and particles has also been performed. Furthermore, sorption experiments have been performed to investigate the association of Pu, Am and Cs with different geological materials. The intercomparison exercises included sequential extraction of Pu, 137Cs, U, Th, and 129I in one soil and one sediment standard reference materials (NIST-4354, IAEA-375) and Pu in sediment collected from the Lake Heimdalen, Norway. (author)
Postmodern Families (2015)

The modern family of sociological theory and historical convention designates a form no longer prevalent in the United States: an intact nuclear household unit composed of a male breadwinner, his full-time homemaker wife, and their dependent children. Feminists intentionally accelerated the modern family's demise. Feminist enthusiasm for female autonomy encouraged women's massive entry into the postindustrial labor market. As postindustrial society became entrenched, many women, perhaps the majority, found their economic and personal conditions worsening. The group bore far greater resemblance to the postmodern family of the imaginary twenty-first-century Joneses than it did to the image of traditional family life that arouses the nostalgic fantasies so widespread among critics of contemporary family practices. The postmodern family is not a new model of family life, not the next stage in an orderly progression of family history, but the stage when the belief in a logical progression of stages breaks down.
Fibre Bragg grating characterization with ultraviolet-based interferometric side diffraction (2003)

The interferometric side diffraction method for fibre Bragg grating characterization is evaluated using a set-up with an ultraviolet interrogation beam. In its present configuration, the reproducibility errors are 2–5% for the index and typically 10°–20° for the phase profile. The reflection spectra of chirped test gratings have been successfully reproduced with the aid of the acquired phase and refractive index envelope data. It is verified that the power of the interrogating beam, within some limits, is unimportant as regards the phase reproducibility, and the importance of relating the analysis to the fabrication parameters of the grating under investigation is stressed.
Stability of an Euler-Bernoulli beam with a nonlinear dynamic feedback system (2015)

This paper is concerned with the stability analysis of a lossless Euler-Bernoulli beam that carries a tip payload which is coupled to a nonlinear dynamic feedback system. This setup comprises nonlinear dynamic boundary controllers satisfying the nonlinear KYP lemma as well as the interaction with a nonlinear passive environment. Global-in-time wellposedness and asymptotic stability is rigorously proven for the resulting closed-loop PDE-ODE system. The analysis is based on semigroup theory for the corresponding first order evolution problem. For the large-time analysis, precompactness of the trajectories is shown by deriving uniform-in-time bounds on the solution and its time derivatives.
Galectin-3 is strongly up-regulated in nonapoptosing mammary epithelial cells during rat mammary gland involution (2002)

Galectin-3 is an endogenous mammalian lectin that binds to ABH carbohydrate antigens. Here we show that galectin-3 is strongly up-regulated during mammary gland involution and that it is expressed virtually exclusively on nonapoptotic cells. We demonstrate that dexamethasone, an inhibitor of the second phase of mammary gland involution, potently suppresses up-regulation of galectin-3 as judged immunohistochemically and on western blots, suggesting that systemic hormone levels regulate galectin-3 expression during involution. However, at the RNA level galectin-3 expression is rapidly up-regulated on the onset of involution but remains consistantly high during the first and second phase of involution regardless of dexamethasone treatment. These data suggest that the up-regulation of galectin-3 in the involuting mammary gland is not only controlled transcriptionally but also regulated posttranscriptionally under the control of systemic glucocorticoid hormones involved in coordinating the involution process.
Aspergillus flavus‐induced chitosanase in germinating corn and peanut seeds:A. flavusmechanism for growth dominance over associated fungi and concomitant aflatoxin production (1995)

Chitosanase, a new class of enzymes with antifungal properties was induced by toxigenic Aspergillus flavus in both germinating corn and peanut seeds. The enzyme was partially purified and fractioned by SDS-Polyacrylamide Gel Electrophoresis activity and copolymerized with chitosan or glycolchitosan as substrate, then quantified by scanning densitometry and a 2-dimensional analysis software program. Chitosanase enzyme was markedly induced by toxigenic A. flavus growing in germinating corn and peanut seeds, as compared to control (water) which showed the lowest activity (almost nil in corn). However, chitosanase induction was higher in seeds treated with chitosan from crustacea. Overall, enzyme activity was higher in peanut than in corn seeds. However, electrophoresed gels from peanut treated with A. flavus or water showed more polypeptides (three and one, respectively) than gels from corn seeds, which only showed one polypeptide for both A. flavus and water treatment. The enzyme molecular weight was estimated to be between 36,000 and 45,000.
320 Gbit/s (8 × 40 Gbit/s) WDM transmissionover 367 km with 120 km repeater spacingusing carrier-suppressed return-to-zero format (1999)

The authors demonstrate +11 dBm-per-channel 320 Gbit/s (8 × 40 Gbit/s) WDM transmission over a 367 km zero-dispersion-flattened transmission line with 120 km repeater spacing using a nonlinearity-tolerant carrier-suppressed return-to-zero format.
Design of a four degree-of-freedom force-reflecting manipulandum with a specified force/torque workspace (2002)

It is noted that the performance of force-reflecting hand controllers, also called manual interfaces or manipulanda, is at present limited more by mechanical design than by computing hardware. Some of the important mechanical features of a high-performance manual interface are low inertia, low friction, high stiffness, backdriveability, high output force capability, multiple degrees-of-freedom, and sizable range of motion. A four-degree-of-freedom manipulandum that utilizes a three-degree-of-freedom parallel-link mechanism was designed to incorporate these features. The kinematic design of the manipulator prompted the definition of a force/torque workspace as the volume of operation within which certain maximum desired endpoint forces and torques can be achieved, given actuators of limited output. The design requires low actuator torques, is small in size, and does not approach joint limits in the workspace.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Evidence That Single Missense Mutations in the Atp7a Gene of Two Mouse Models for Menkes' Disease Are Responsible for Impaired Copper Transport. (2000)

Menkes' disease is an inherited disorder of copper homeostasis that arises from a deficiency in copper-transporting P-type ATPase, the mouse gene for which is designated Atp7a. The macular and the viable-brindled mouse are among Menkes' disease models and have been shown to have respective single missense mutations in their genes. In this study we tested whether these mutations are a cause of the disease. Yeast strain Δccc2, lacking CCC2, the yeast homologue of Atp7a, was used to examine whether this mutant yeast can be rescued by expression of acular or viable-brindled Atp7a protein when cultured in copper- and iron-deficient medium. Expression of both mutant Atp7a proteins was found to enable the growth of Δccc2 yeast, but the growth rates were less than one-fifth of the rate observed for Δccc2 yeast expressing wild-type Atp7a protein. Thus it is clear that the missense mutations of both animal models for Menkes' disease are responsible for the impaired function of copper transport.
Microwave reflectometry: A high-resolution technique for measuring vibration of capacitive microresonators (2013)

The paper proposes a novel technique for measuring the vibration of capacitive microelectromechanical resonators. Based on microwave reflectometry in the gigahertz range, the technique offers signal-to-noise ratio greater than 100 dB for the studied device and it rejects any parasitic crosstalk due to stray capacitances. Experiments demonstrate that amplitude resolution better than 10 fm/√Hz is achieved, which competes with standard optical interferometry. The technique is particularly appropriate for electrical characterization of MEMS devices but also for signal processing of resonant sensors when large-bandwidth, high signal-to-noise ratio and fully electrical detection is required.
Bio-efficacy of glufosinate-ammonium under zero tillage in mustard and on Cynodon dactylon (L.) Pers and Cyperus rotundus L. under non-crop situation. (2002)

Conventional tillage recorded significantly lower total weed fresh biomass than paraquat (500 g ha−1) and glufosinate (300 g ha−1). Otherwise all other treatments including glufosinate (300 g ha−1) were equally good as conventional tillage. Pendimethalin and isoproturon remained at par, but recorded significantly lower broad-leaved and total weed fresh weight than control. Glufosinate (300, 450 and 600 g ha−1), glyphosate, paraquat, weed free (before sowing) and conventional tillage when supplemented with pendimethalin recorded a little higher seed yield of mustard than when applied alone. Glufosinate alone and glufosinate + pendimethalin at their respective doses, however remained at par. Glufosinate (450 g ha−1) was superior to glufosinate (375 g ha−1) in controlling Cynodon dactylon both at 20 DAT as well as at 40 DAT. Higher the dose of glyphosate, the greater was the Cynodon controll Paraquat alone remained quiie effective at 20 DAT, but proved inconsistent. However, paraquat (500 g ha−1) when mixed with glufosinate or glyphosate (150 g ha−1 and 410 g ha”−1, respectively) gave excellent control of Cynodon. Except metribuzin, all the herbicides including glufosinate (at both 375 g ha−1 and 450 g ha−1) recorded significantly lower fresh weight/dry weight ratio of Cyperus rotundus that in unweeded control at 20 DAT. However at 40 DAT, only glufosinate and glyphosate proved highly effective in reducing Cyperus growth than unweeded control.
1,2-Diacylation of Alkynes Using Acyl Fluorides and Acylsilanes by P(III)/P(V) Catalysis (2023)

We report herein the phosphine-catalyzed 1,2-diacylation of alkynes using acyl fluorides and acylsilanes as acyl sources. The key to the success of the reaction is a formal oxidative addition-ligand metathesis-reductive elimination cycle based on phosphine redox catalysis, which allows for the installation of two different acyl groups into an alkyne in a regioselective manner.
Correction to "Chemical-moisture barrier cable-concept and practice" (1996)

The authors describe how, in the original paper, "Chemical-moisture barrier cable-concept and practice" (see ibid., vol. 31, no. 6, p. 1390-7, 1995), Figure 3 was omitted and Figure 5 was printed incorrectly. The missing and corrected figures are shown in this paper.
Mobile. Egocentric Human Body Motion Reconstruction Using Only Eyeglasses-mounted Cameras and a Few Body-worn Inertial Sensors (2021)

We envision a convenient telepresence system available to users anywhere, anytime. Such a system requires displays and sensors embedded in commonly worn items such as eyeglasses, wristwatches, and shoes. To that end, we present a standalone real-time system for the dynamic 3D capture of a person, relying only on cameras embedded into a head-worn device, and on Inertial Measurement Units (IMUs) worn on the wrists and ankles. Our prototype system egocentrically reconstructs the wearer's motion via learning-based pose estimation, which fuses inputs from visual and inertial sensors that complement each other, overcoming challenges such as inconsistent limb visibility in head-worn views, as well as pose ambiguity from sparse IMUs. The estimated pose is continuously re-targeted to a prescanned surface model, resulting in a high-fidelity 3D reconstruction. We demonstrate our system by reconstructing various human body movements and show that our visual-inertial learning-based method, which runs in real time, outperforms both visual-only and inertial-only approaches. We captured an egocentric visual-inertial 3D human pose dataset publicly available at https://sites.google.com/site/youngwooncha/egovip for training and evaluating similar methods.
Devices, base stations, and methods for communicating scheduling requests via an underlay control channel in a wireless communication system (2023)

Wireless communication systems, base stations, and user equipment are disclosed that enable communication of scheduling requests via an underlay control channel that has an energy below a noise level of the spectrum. The scheduling requests may be sent and received at any time, including during downlink and uplink data communication periods of the base station.