gebhart/patrepeval huggingface dataset:
Comparison of the effect of atropine and cyclopentolate on myopia. (1989)

We evaluated the effectiveness of cycloplegics in the treatment of myopia. Patients were selected randomly and divided into three groups: Group 1 received atropine 1% eye drops every other night; Group 2 received cyclopentolate 1% eye drops every night; and Group 3 received normal saline eye drops every night. All the patients were rechecked every three months. The results were evaluated at the end of one year. Ninety-six patients were evaluated, 32 in each group. The mean myopic progression was -0.219 D in the atropine group, -0.578D in the cyclopentolate group, and -0.914D in the saline group. Analysis showed that atropine and cyclopentolate are effective in slowing the progression of myopia. The effect of atropine is better than that of cyclopentolate.
Modelisation par la CPFDTD d'une antenne monopole triangle repliee. (2001)

National audience
Design and Testing of a Compliant Floating-Opposing-Arm (FOA) Centrifugal Clutch (2000)

Abstract A floating-opposing-arm (FOA) centrifugal clutch is presented that uses compliant segments to reduce the part count and increase manufacturability. The clutch performs all of the functions of a centrifugal clutch, but consists of only two pieces. Torque is increased by connecting aggressive and non-aggressive contact surfaces in connected pairs. This arrangement increases the torque output of the FOA clutch by over 100% relative to a commercial one-piece compliant centrifugal clutch design of the same size and material. Yet, since this design is compliant, it remains simple to manufacture. This clutch is presented and modeled using the pseudo-rigid-body-model (PRBM) technique. The model predictions are compared to test data from five prototypes. The FOA clutch is also demonstrated in a gasoline-powered string trimmer.
Design and demonstration of a novel incoherent optical CDMA system (2005)

A detailed analysis of the scalability of two-dimensional optical codes is presented and two network deployment architectures for optical code division multiple access (OCDMA) are discussed. We present the architecture and code design for a highly scalable, 2.5 Gb/s per user OCDMA system. The system is scalable to 100 potential and more than 10 simultaneous users, each with BER of less than 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-9</sup> . The system architecture uses fast wavelength-hopping, time-spreading codes. Unlike phase sensitive coherent OCDMA systems, this architecture utilizes standard on-off-keyed optical pulses allocated in the time and wavelength domains. This incoherent OCDMA approach is compatible with existing WDM optical networks and utilizes off-the-shelf components. We discuss a novel optical subsystems design for encoders and decoders that enable the realization of a highly scalable incoherent OCDMA system with rapid reconfigurability. We demonstrate the operation of 4 simultaneous users operating at OC-48 (~2.5 Gbit/s) with a power penalty of <;0.5dB and the reduction of multiple-access interference using ultra-fast all-optical sampling with newly proposed TOAD-based OCDMA receiver.
A study of the thermal cure of a phenylethynyl‐terminated imide model compound and a phenylethynyl‐terminated imide oligomer (PETI‐5) (1998)

The kinetic mechanism of the thermal cure of a phenylethynyl-terminated imide model compound, 3,4′-bis[(4-phenylethynyl)phthalimido]diphenyl ether (PEPA-3,4′-ODA) and a phenylethynyl-terminated imide oligomer PETI-5 (MW 5000 g/mol) was studied. FTIR was used to follow the cure of the model compound, while thermal analyses (DSC) was used to follow the cure of the PETI-5 oligomer. The changes in IR absorbance of phenylethynyl triple bonds at 2214 cm−1 of PEPA-3,4′-ODA as a function of cure time were detected at 318, 336, 355, and 373°C, respectively. The changes in the glass transition temperature, Tg, of PETI-5 as a function of time were measured at 350, 360, 370, 380, and 390°C, respectively. The DiBenedetto equation was applied to define the relative extent of cure, x, of the PETI-5 oligomer by Tg. For the model compound, the reaction followed first order kinetics, yielding an activation energy of 40.7 kcal/mol as determined by infrared spectroscopy. For PETI-5, the reaction followed 1.5th order, yielding an activation energy of 33.8 kcal/mol for the whole cure reaction, as determined by Tg using the DiBenedetto method. However, the cure process of PETI-5 just below 90% by this method followed first-order kinetics yielding an activation energy of 37.2 kcal/mol. © 1998 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 36: 461–470, 1998
Abstract TP272: Air versus Ground Transport for Interhospital Transfer Prior to Endovascular Stroke Treatment (2019)

Introduction: Interhospital transfer for endovascular treatment of large vessel occlusion (LVO) stroke results in significant delays and worse outcomes. We hypothesized that interhospital patient transfer using air transport would result in shorter transit times compared to ground ambulance. Methods: Subjects from the STRATIS registry that underwent interhospital transfer for endovascular treatment were separated by air transport vs. ground ambulance transport and analyzed by transfer distance. The primary endpoint was transfer-time, calculated as the time from imaging at the initial hospital to arrival at the treating hospital. Also assessed was travel-time, calculated as time of departure from the initial hospital to arrival at the treating hospital. Results: There were 232 subjects from 41 sites. Mean transfer-time for all air subjects (n=118) was 147.1 min, and for all ground subjects (n=114) was 130.0 min (p=0.019). Mean travel-time was 45.0 min for air transport and 40.2 min for ground transport (p=0.239); though the average travel distance was longer for air (65.5 miles) vs. ground (27.6 miles; p&lt;0.001). When analyzed by distance, there was no difference between air and ground transfer-time except transfers less than 20 miles, which favored ground transportation (154.4 min vs. 119.5 min; p=0.015; see table). The lack of advantage for air transport may be accounted for by the time between imaging and departure from the initial hospital (mean 89.4 vs. 101.6 min; p=0.075), reflecting additional logistics and/or reduced availability of air transport. Conclusions: In this large, real-world study, interhospital transfer via air transport did not result in faster transfer times compared to ground ambulance. In fact, there was an advantage to ground transportation for distances of less than 20 miles. These results suggest that ground ambulance should routinely be used for interhospital transfer of stroke patients for travel less than 20 miles.
Development of a high-power lithium-ion battery. (1998)

Safety is a key concern for a high-power energy storage system such as will be required in a hybrid vehicle. Present lithium-ion technology, which uses a carbon/graphite negative electrode, lacks inherent safety for two main reasons: (1) carbon/graphite intercalates lithium at near lithium potential, and (2) there is no end-of-charge indicator in the voltage profile that can signal the onset of catastrophic oxygen evolution from the cathode (LiCoO{sub 2}). Our approach to solving these safety/life problems is to replace the graphite/carbon negative electrode with an electrode that exhibits stronger two-phase behavior further away from lithium potential, such as Li{sub 4}Ti{sub 5}O{sub 12}. Cycle-life and pulse-power capability data are presented in accordance with the Partnership for a New Generation of Vehicles (PNGV) test procedures, as well as a full-scale design based on a spreadsheet model.
Inductin of Attachment and Metamorphosis of Laboratory Cultures Mussel Mytilus <i>edulis galloprovincialis</i> Larvae by Microbial Film (1995)

Competent pediveliger larvae (26-32 days old) of the mussel Mytilus edulis galloprovincialis attached and metamorphosed when exposed to microbial films but not to unfilmed surfaces. The inducing factor in the microbial film remained active after treatment with 5% formalin solution. However, microbial film lost activity to induce metamorphosis after autoclaving. The films produced by specific strains of bacteria that were isolated from microbial film induced larval attachment and metamorphosis. The two bacterial strains (C 1.1 and C 4.1) which were most potent in inducing larval attachment and metamorphosis were identified with the Pseudomonas-Alteromonas group. This is the first report which demonstrates the direct involvement of specific bacterial strains in the attachment and metamorphosis of mussel pediveliger larvae.
Study of single and multidigit activation in monkey somatosensory cortex using voltage-sensitive dye imaging (2017)

Toward the goal of understanding cutaneous sensory integration during manual behavior, we used voltage-sensitive dye (VSD) imaging to study the organization and dynamics of anesthetized monkey primary somatosensory cortex (SI) in response to single and multidigit tactile stimulation. We find that in both macaque and squirrel monkey SI, VSD reveals clear focal digit topography consistent with previous electrophysiological and intrinsic signal imaging studies. VSD also reveals interactions in SI in response to multidigit stimulation. With a tactile funneling paradigm in areas 3b and 1 in squirrel monkeys, VSD reveals two-digit induction of subthreshhold influences, consistent with lateral intracortical inhibition. In response to tactile apparent motion stimuli, VSD reveals preferential response to motion stimuli over static tactile stimuli in both areas 1 and 3b. Comparison of the response at different digit locations to "toward digit" stimuli suggests the presence of direction-selective response in area 1; however, further study is needed. These exciting results indicate that VSD constitutes a powerful tool for studying somatosensory cortical processing in nonhuman primates and should be further developed for future somatosensory studies in awake behaving monkeys.
Tetragonal YPO4 – a novel SRS-active crystal (2008)

High-order Raman-induced Stokes and anti-Stokes generation was observed in tetragonal YPO 4 crystal. The discovered nonlinear-laser properties of this orthophosphate material significant increase the possibilities for its practical application. The SRS-promoting modes derive both from stretching vibrations of the phosphate ion, and from combinations of these modes.
Probabilistic Appearance Based Navigation and Loop Closing (2007)

This paper describes a probabilistic framework for navigation using only appearance data. By learning a generative model of appearance, we can compute not only the similarity of two observations, but also the probability that they originate from the same location, and hence compute a pdf over observer location. We do not limit ourselves to the kidnapped robot problem (localizing in a known map), but admit the possibility that observations may come from previously unvisited places. The principled probabilistic approach we develop allows us to explicitly account for the perceptual aliasing in the environment - identical but indistinctive observations receive a low probability of having come from the same place. Our algorithm complexity is linear in the number of places, and is particularly suitable for online loop closure detection in mobile robotics.
Immortalized human adult articular chondrocytes maintain cartilage-specific phenotype and responses to interleukin-1β (2000)

The tsT/AC62 cells provide a reproducible model that mimics the adult articular chondrocyte phenotype, particularly in alginate culture, and demonstrates characteristic responses to IL-1beta. These studies also show, for the first time, that p38 MAPK is one of the signals required for IL-1beta-induced inhibition of COL2A1 gene expression. Availability of this model will permit identification of signals that regulate cytokine responses, and will also provide rational strategies for targeting these pathways.
Analysis of interactive packing of secondary structural elements in α/β units in proteins (1999)

An alpha-helix and a beta-strand are said to be interactively packed if at least one residue in each of the secondary structural elements loses 10% of its solvent accessible contact area on association with the other secondary structural element. An analysis of all such 5,975 nonidentical alpha/beta units in protein structures, defined at < or = 2.5 A resolution, shows that the interaxial distance between the alpha-helix and the beta-strand is linearly correlated with the residue-dependent function, log[(V/nda)/n-int], where V is the volume of amino acid residues in the packing interface, nda is the normalized difference in solvent accessible contact area of the residues in packed and unpacked secondary structural elements, and n-int is the number of residues in the packing interface. The beta-sheet unit (beta u), defined as a pair of adjacent parallel or antiparallel hydrogen-bonded beta-strands, packing with an alpha-helix shows a better correlation between the interaxial distance and log(V/nda) for the residues in the packing interface. This packing relationship is shown to be useful in the prediction of interaxial distances in alpha/beta units using the interacting residue information of equivalent alpha/beta units of homologous proteins. It is, therefore, of value in comparative modeling of protein structures.
The dimeric platelet collagen receptor GPVI-Fc reduces platelet adhesion to activated endothelium and preserves myocardial function after transient ischemia in mice (2012)

Platelets play a critical role in the pathophysiology of reperfusion, sepsis, and cardiovascular diseases. In a multiple step process, they adhere to activated endothelium and release proinflammatory cytokines thereby promoting the inflammatory process. Glycoprotein VI (GPVI) is the major collagen receptor on the platelet surface and triggers platelet activation and primary hemostasis. Activation of GPVI leads to stable platelet adhesion and degranulation of platelet granules. However, GPVI is critically involved in platelet adhesion to activated endothelium without exposure of subendothelial matrix. Earlier studies show that the soluble GPVI-Fc binds to collagen and protects mice from atherosclerosis and decreases neointima proliferation after arterial injury. Here, we show for the first time that recombinant GPVI-Fc binds to activated endothelium mainly via vitronectin and prevents platelet/endothelial interaction. Administration of GPVI-Fc reduced infarct size and preserved cardiac function in a mouse model of myocardial infarction. This process was associated with reduced GPVI-induced platelet degranulation and release of proinflammatory cytokines in vitro and in vivo. Taken together, administration of GPVI-Fc offers a novel strategy to control platelet-mediated inflammation and to preserve myocardial function following myocardial infarction.
ChemInform Abstract: REACTIONS OF 3‐SUBSTITUTED QUINOLINE N‐OXIDES (1975)

Abstract 3,2′‐Dichinolyl (I) liefert mit m‐Chlorperbenzoesäure das 1‐Monoxid (II) oder das Di‐N‐oxid (III).
Identification of a Subpopulation of Marrow MSC-Derived Medullary Adipocytes That Express Osteoclast-Regulating Molecules: Marrow Adipocytes Express Osteoclast Mediators (2014)

Increased marrow medullary adipogenesis and an associated decrease in bone mineral density, usually observed in elderly individuals, is a common characteristic in senile osteoporosis. In this study we investigated whether cells of the medullary adipocyte lineage have the potential to directly support the formation of osteoclasts, whose activity in bone leads to bone degradation. An in vitro mesenchymal stem cell (MSC)-derived medullary adipocyte lineage culture model was used to study the expression of the important osteoclast mediators RANKL, M-CSF, SDF-1, and OPG. We further assessed whether adipocytes at a specific developmental stage were capable of supporting osteoclast-like cell formation in culture. In vitro MSC-derived medullary adipocytes showed an mRNA and protein expression profile of M-CSF, RANKL, and OPG that was dependent on its developmental/metabolic stage. Furthermore, RANKL expression was observed in MSC-derived adipocytes that were at a distinct lineage stage and these cells were also capable of supporting osteoclast-like cell formation in co-cultures with peripheral blood mononuclear cells. These results suggest a connection between medullary adipocytes and osteoclast formation in vivo and may have major significance in regards to the mechanisms of decreased bone density in senile osteoporosis.
Results from conceptual design study of potential early commercial MHD/steam power plants (1981)

This paper presents conceptual design information for a potential early MHD power plant developed in the second phase of a joint study of such plants. Conceptual designs of plant components and equipment with performance, operational characteristics and costs are reported on. Plant economics and overall performance including full and part load operation are reviewed. Environmental aspects and the methods incorporated in plant design for emission control of sulfur and nitrogen oxides are reviewed. Results from reliability/availability analysis conducted are also included.
Ischemia-Induced Interleukin-6 as a Potential Endogenous Neuroprotective Cytokine against NMDA Receptor-Mediated Excitoxicity in the Brain (2000)

In the brain, the expression of the pleiotropic cytokine interleukin-6 (IL-6) is enhanced in various chronic or acute central nervous system disorders. However, the significance of IL-6 production in such neuropathologic states remains controversial. The present study investigated the role of IL-6 after cerebral ischemia. First, the authors showed that focal cerebral ischemia in rats early up-regulated the expression of IL-6 mRNA, without affecting the transcription of its receptors (IL-6Ralpha and gp130). Similarly, the striatal injection of N-methyl-D-aspartate (NMDA) in rats, a paradigm of excitotoxic injury, activated the expression of IL-6 mRNA. The involvement of glutamatergic receptor activation was further investigated by incubating cortical neurons with NMDA or alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA). NMDA and ionomycin (a calcium ionophore) up-regulated IL-6 mRNA, suggesting that neurons may produce IL-6 in response to the calcium influx mediated through NMDA receptors. The potential role of IL-6 during ischemic/excitotoxic insults was then studied by testing the effect of IL-6 against apoptotic or excitotoxic challenges in cortical cultures. IL-6 did not prevent serum deprivation- or staurosporine-induced apoptotic neuronal death, or AMPA/kainate-mediated excitotoxicity. However, in both mixed and pure neuronal cultures, IL-6 dose-dependently protected neurons against NMDA toxicity. This effect was blocked by a competitive inhibitor of IL-6. Overall, the results suggest that the up-regulation of IL-6 induced by cerebral ischemia could represent an endogenous neuroprotective mechanism against NMDA receptor-mediated injury.
Risk factor screening for gestational diabetes mellitus based on the 2013 WHO criteria (2019)

By applying selective screening by European guidelines, about 50% of women would need an OGTT with the lowest number of missed cases (33%) by the Dutch guidelines. Screening with age ≥30 years and/or BMI ≥25, reduced the number of missed cases to 18.6% but 70% would need an OGTT.
2D FeSx Nanosheets by Atomic Layer Deposition: Electrocatalytic Properties for the Hydrogen Evolution Reaction (2023)

2-dimensional FeS<sub>x</sub> nanosheets of different sizes are synthesized by applying different numbers of atomic layer deposition (ALD) cycles on TiO<sub>2</sub> nanotube layers and graphite sheets as supporting materials and used as an electrocatalyst for the hydrogen evolution reaction (HER). The electrochemical results confirm electrocatalytic activity in alkaline media with outstanding long-term stability (>65 h) and enhanced catalytic activity, reflected by a notable drop in the initial HER overpotential value (up to 26 %). By using a range of characterization techniques, the origin of the enhanced catalytic activity was found to be caused by the synergistic interplay between in situ morphological and compositional changes in the 2D FeS<sub>x</sub> nanosheets during HER. Under the application of a cathodic potential in alkaline media, the as-synthesized 2D FeS<sub>x</sub> nanosheets transformed into iron oxyhydroxide-iron oxysulfide core-shell nanoparticles, which exhibited a higher active catalytic surface and newly created Fe-based HER catalytic sites.
Tonometer calibration; determination of Pt formula by use of strain gauge and recording potentiometer on enucleated normal human eyes. (1957)

I. Introduction The Committee on Standardization of Tonometers of the American Academy of Ophthalmology and Otolaryngology has performed a valuable service in arranging for manufacturers to produce tonometers which are uniform in their various weights and measurements and which give consistent readings. These certified instruments have made possible the comparison of readings taken with different tonometers by different persons in different parts of the country. Thus, a scale reading of 3.0 with the 5.5 gm. weight on a Schiotz certified tonometer taken by Dr. Smith in New York on a given patient is equivalent to the same reading taken on another certified tonometer by Dr. Brown in Chicago on the same patient. Accurate calibration of tonometers is important for a number of reasons. Since the Schiotz tonometer uses several weights, it should be possible to detect variations in ocular rigidity clinically and to compensate for them. Tonography depends very definitely
Effect of Temperature on Athabasca Type Heavy Oil – Water Relative Permeability Curves in Glass Bead Packs (2012)

There have been a number of somehow contradictory reports in the literature on the effect of temperature on oil and water relative permeabilities. Although some authors have reported the dependence of relative permeability curves on temperature, others have attributed these dependencies to artifacts inherent in unsteady-state method of relative permeability measurement. In order to further investigate the impact of temperature changes on the relative permeability data, we have conducted laboratory core flooding experiments on heavy oil systems. The porous media used was glass bead packs, and the Athabasca type bitumen with varying viscosities was displaced by hot water. The history matching technique was conducted on production and pressure differential data to get the relative permeability curves. Results indicated that generally the increase in initial water saturation and the decrease in residual oil saturation are expected by increasing temperature. However, viscous instabilities can rule out the above mentioned trends. No temperature dependency of either oil or water relative permeability can be justified in our tests. The changes in relative permeabilities by temperature are probably related to experimental artifacts, viscous fingering and changes in oil to water viscosity ratio and not fundamental flow properties.