gebhart/patrepeval huggingface dataset:
4-Nitroindazole: Its Ambiguous Nature in Oligonucleotide Base Pairing and the Influence of the Glycosylation Position on the Duplex Stability (2002)

Oligonucleotides incorporating the regioisomeric 4-nitroindazole N1- and N2-(2′-deoxy-β-D-ribofuranosides) 7 and 8 were synthesized and their base-pairing properties investigated. For solid-phase synthesis, the phosphoramidites 11 and 12 were prepared. Oligonucleotides containing the building block 7 or 8 show ambiguous base pairing. Duplexes have similar Tm values when the modified bases are positioned opposite to the four canonical DNA constituents. The glycosylation position of the regioisomeric 4-nitroindazole nucleosides has very little influence on the duplex stability.
Study of Mechanical Properties of Engineered Cartilage in an in Vivo Culture for Design of a Biodegradable Scaffold (2010)

Biodegradable Neoveil® had good biocompatibility and was able to support extracellular matrix formation in engineered cartilage in an animal model.
Two genes differentially regulated in the cell cycle and by DNA-damaging agents encode alternative regulatory subunits of ribonucleotide reductase. (1990)

Ribonucleotide reductase activity is essential for progression through the cell cycle, catalyzing the rate-limiting step for the production of deoxyribonucleotides needed for DNA synthesis. The enzymatic activity of the enzyme fluctuates in the cell cycle with an activity maximum in S phase. We have identified and characterized two Saccharomyces cerevisiae genes encoding the regulatory subunit of ribonucleotide reductase, RNR1 and RNR3. They share approximately 80% amino acid identity with each other and 60% with the mammalian homolog, M1. Genetic disruption reveals that the RNR1 gene is essential for mitotic viability, whereas the RNR3 gene is not essential. A high-copy-number clone of RNR3 is able to suppress the lethality of rnr1 mutations. Analysis of mRNA levels in cell-cycle-synchronized cultures reveals that the RNR1 mRNA is tightly cell-cycle regulated, fluctuating 15- to 30-fold, and is coordinately regulated with the POL1 mRNA, being expressed in the late G1 and S phases of the cell cycle. Progression from the alpha-factor-induced G1 block to induction of RNR1 mRNA is blocked by cycloheximide, further defining the requirement for protein synthesis in the G1- to S-phase transition. Both RNR1 and RNR3 transcripts are inducible by treatments that damage DNA, such as 4-nitroquinoline-1-oxide and methylmethanesulfonate, or block DNA replication, such as hydroxyurea. RNR1 is inducible 3- to 5-fold, and RNR3 is inducible greater than 100-fold. When MATa cells are arrested in G1 by alpha-factor, RNR1 and RNR3 mRNA is still inducible by DNA damage, indicating that the observed induction can occur outside of S phase. Inhibition of ribonucleotide reductase activity by hydroxyurea treatment results in arrest of the cell cycle in S phase as large budded, uninucleate cells. This specific cell-cycle arrest is independent of the RAD9 gene, defining a separate pathway for the coordination of DNA synthesis and cell-cycle progression.
The challenges of commodity-based visualization clusters (2006)

The performance of commodity computer components continues to increase dramatically. Processors, internal I/O buses, graphics cards, and network adapters have all exhibited significant improvements without significant increases in cost. Due to the increase in the price/performance ratio of computers utilizing such components, clusters of commodity machines have become commonplace in today's computing world and are steadily displacing specialized, high-end, shared-memory machines for many graphics and visualization workloads. Acceptance, and more importantly utilization, of commodity clusters has been hampered, however, due to the significant challenges introduced when switching from a shared-memory architecture to a distributed memory one. Such challenges range from having to redesign applications for distributed computing to gathering pixels from multiple sources and finally synchronizing multiple video outputs when driving large displays. In addition to these impediments for the application developer, there are also many mundane problems which arise when working with clusters, including their installation and general system administration.This paper details these challenges and the many solutions that have been developed in recent years. As the nature of commodity hardware components suggests, the solutions to these research challenges are largely softwarebased, and include middleware layers for distributing the graphics workload across the cluster as well as for aggregating the final results to display for the user. At the forefront of this discussion will be IBM's Deep View project, whose goal has been the design and implementation of a scalable, affordable, high-performance visualization system for parallel rendering. In the past six years, Deep View has undergone numerous redesigns to make it as efficient as possible. We highlight the issues involved in this process, up to and including the current incarnation of Deep View, as well as what's on the horizon for cluster-based rendering.
Canagliflozin improves glycaemic control over 28 days in subjects with type 2 diabetes not optimally controlled on insulin (2012)

In subjects receiving insulin and oral antihyperglycaemic therapy, canagliflozin was well tolerated without evidence for glucose malabsorption, had pharmacokinetic characteristics consistent with once-daily dosing, and improved glycaemic control.
Presentation of menopausal symptoms: A village based community study (2014)

Background: The present observational, cross sectional study was carried out in rural women (n=117) from the Varanasi area with natural menopause to evaluate menopausal symptoms in women above the age of 40, as well as to evaluate the correlation of age on these symptoms. Materials and Methods: A crossectional assessment by interviewing regarding the menopausal complaints in the following 40-44(n=27), 45- 50(n=30) and above 50 (n =60) years age groups. Menstrual rating scale (MRS) was administered to all the women forming the sample. Results: Mean age at menopause was 47.35 years. Mean number of menopausal symptoms in three age groups were as (mean±SD)10.53±7.33, 7.70± 6.76 and14.50±10.77 respectively, which varied significantly (F=4.86, df=2, 87, P=0.009). The study reveal, varying nature of symptoms with age and MDSM (Mean Duration since Menopause), with vasomotor symptoms being more prevalent with lesser MDSM and psychological and rheumatic complaints more prevalent with increasing age and MDSM in this region. Conclusion: Such regional studies will help to corroborate data so that health care providers can plan strategies for the middle aged women suffering from these menopausal symptoms. DOI: http://dx.doi.org/10.3126/ajms.v6i1.8431 Asian Journal of Medical Sciences Vol.6(1) 2015 87-90
In vitro model for lipase-catalyzed lipophile release from fats (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIn vitro model for lipase-catalyzed lipophile release from fatsFouad M. Fouad, Patrick G. Farrell, William D. Marshall, and Frederik R. Van de VoortCite this: J. Agric. Food Chem. 1991, 39, 1, 150–153Publication Date (Print):January 1, 1991Publication History Published online1 May 2002Published inissue 1 January 1991https://pubs.acs.org/doi/10.1021/jf00001a029https://doi.org/10.1021/jf00001a029research-articleACS PublicationsRequest reuse permissionsArticle Views68Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Xylem colonization of the legume Sesbania rostrata by Azorhizobium caulinodans (1997)

A novel pathway of invasion of the legume Sesbania rostrata by Azorhizobium caulinodans is described that involves colonization of the root xylem, possibly following entry into the natural fissures created during emergence of lateral roots. Azorhizobia were detected microscopically, and their presence confirmed by the expression of a lacZ reporter gene. We have shown that rhizobial Nod factors are not required for either xylem colonization or for crack–entry of lateral roots. We discuss the extent to which this discovery of xylem colonization by azorhizobia is likely to improve our understanding of both symbiosis and of pathogenicity in plant–bacterial interactions.
Granger causality in integrated GC–MS and LC–MS metabolomics data reveals the interface of primary and secondary metabolism (2012)

<i>Metabolomics</i> has emerged as a key technique of modern life sciences in recent years. Two major techniques for metabolomics in the last 10 years are gas chromatography coupled to mass spectrometry (GC-MS) and liquid chromatography coupled to mass spectrometry (LC-MS). Each platform has a specific performance detecting subsets of metabolites. GC-MS in combination with derivatisation has a preference for small polar metabolites covering primary metabolism. In contrast, reversed phase LC-MS covers large hydrophobic metabolites predominant in secondary metabolism. Here, we present an integrative metabolomics platform providing a mean to reveal the interaction of primary and secondary metabolism in plants and other organisms. The strategy combines GC-MS and LC-MS analysis of the same sample, a novel alignment tool MetMAX and a statistical toolbox COVAIN for data integration and linkage of Granger Causality with metabolic modelling. For metabolic modelling we have implemented the combined GC-LC-MS metabolomics data covariance matrix and a stoichiometric matrix of the underlying biochemical reaction network. The changes in biochemical regulation are expressed as differential Jacobian matrices. Applying the Granger causality, a subset of secondary metabolites was detected with significant correlations to primary metabolites such as sugars and amino acids. These metabolic subsets were compiled into a stoichiometric matrix N. Using N the inverse calculation of a differential Jacobian J from metabolomics data was possible. Key points of regulation at the interface of primary and secondary metabolism were identified.
Modifying the radiative quantum efficiency of erbium-doped glass in silicon slot waveguides (2009)

We have modulated the radiative emission rate of Er In SI slot waveguides with Er-doped glass slots by varying the waveguide layer dimensions. The corresponding quantum efficiency of 1537-nm emission varies between 0.37 and 0.51.
Disturbance Sources in the Diesel Engine Combustion Process (2013)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;When a diesel engine is running at steady state, the diesel combustion process still has some level of variation from cycle to cycle, even if engine load and all control inputs are fixed. This variation is a disturbance for the speed governor, and it could lead to less than optimal engine performance in terms of fuel economy, exhaust gas emission and noise emission.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;The most effective way to reduce this steady state combustion variation is by applying fuel path feedback control. The control action can be performed at a fixed frequency, or at a defined cycle event time. Intra-cycle control has the highest capacity to suppress the combustion deviation, as it measures the current cycle combustion performance and compensates for it within the same cycle using a very fast control response. Correct knowledge and a model of the disturbance sources and combustion variation patterns are essential in the design process of this intra-cycle control strategy.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;This paper presents a detailed study of identifying disturbance sources to the combustion process within fuel injection system. The study of influence of other factors on combustion variability such as: residual fraction mass, mixture compositions and distribution, coolant flow speed, air path fluctuation is not the content of this paper. Statistical correlation analysis, principal component analysis and factor analysis methods were used in singling out specific aspects of the disturbance, some of which can be attributed to known sources of variability in the fuel path. The preliminary analysis points to two dominant sources of disturbances: variations in the common fuel rail pressure and variations in the injector current.&lt;/div&gt;&lt;/div&gt;
P663Marked elevation of GDF-15 in cardiogenic shock: early discrimination between survivors and non-survivors (2017)

and D) showed significantly higher incidence of MACEs (HR 1.36, p=0.002 and HR 1.40, p=0.008), but not lower hs-CRP and lower eGFR subset; group B (HR 1.24, 95% CI 0.94-1.64, p=0.131).
Irradiated B7-1 transduced primary acute myelogenous leukemia (AML) cells can be used as therapeutic vaccines in murine AML (1996)

Recent studies have shown that tumor cells genetically modified by transduction of B7-1, a natural ligand for the T-cell costimulatory molecules CD28 and CTLA-4, are rejected in syngeneic hosts. In these reports, transformed cell lines and drug-selected cells have been used for vaccinations. To determine the effectiveness of B7-1-transduced primary acute myelogenous leukemia (AML) cells on the induction of antitumor immunity, we have studied a murine AML model in which primary AML cells were retrovirally transduced with the murine B7-1 cDNA. A defective retroviral producer clone expressing B7-1 and secreting a high titer of virus was used for infection of AML cells. Unselected transduced AML cells, expressing a high level of B7-1, were used for in vivo vaccinations. Our results show that one intravenous (IV) injection of irradiated B7-1-positive (B7-1+) AML cells can provide long-lasting (5 to 6 months) systemic immunity against subsequent challenge with wild-type AML cells. Furthermore, one exposure to irradiated B7-1+ AML cells results in rejection of leukemia by leukemic mice when the vaccination occurs in the early stages of the disease. The antileukemia immunity is CD8+ T-cell-dependent and B7/CD28-mediated, since in vivo treatment of mice with anti-CD8 monoclonal antibody or CTLA-4 Ig leads to abrogation of the specific antileukemia immune response. These results emphasize that B7-1 vaccines may have therapeutic usefulness for patients with AML.
ON THE SENSITIVITY ANALYSIS OF ANALOG CIRCUITS (2008)

Abstract The paper presents three procedures for the sensitivity analysis using auxiliary circuits: the Bykhovsky Perkins Cruz’s method, the incremental-circuit approach and the adjoint-circuit approach. All methods, based on the auxiliary circuits, have needed an efficient partially-symbolic method for the circuit analysis. For this, it was elaborated a very good procedure for the partially-symbolic analysis of the circuits based on the modified nodal equations and on the semi-state equations. This method was implemented in a program- SYCIAN – Symbolic Circuit Analysis. SYCIAN program can analysis together the original circuit and the auxiliary circuit for the complex linear time-invariant analog circuits. In this paper we will show that the methods of the sensitivity computation, based on the auxiliary circuits, become very competitive ones, if it is used the SYCIAN program. It is also underlined the advantages and disadvantages of the three procedures. Some illustrative examples are presented.
Radiographic Visibility Limit of Pores in Metal Powder for Additive Manufacturing (2020)

The quality of additively manufactured (AM) parts is determined by the applied process parameters used and the properties of the feedstock powder. The influence of inner gas pores in feedstock particles on the final AM product is a phenomenon which is difficult to investigate since very few non-destructive measurement techniques are accurate enough to resolve the micropores. 3D X-ray computed tomography (XCT) is increasingly applied during the process chain of AM parts as a non-destructive monitoring and quality control tool and it is able to detect most of the pores. However, XCT is time-consuming and limited to small amounts of feedstock powder, typically a few milligrams. The aim of the presented approach is to investigate digital radiography of AM feedstock particles as a simple and fast quality check with high throughput. 2D digital radiographs were simulated in order to predict the visibility of pores inside metallic particles for different pore and particle diameters. An experimental validation was performed. It was demonstrated numerically and experimentally that typical gas pores above a certain size (here: 3 to 4.4 µm for the selected X-ray setup), which could be found in metallic microparticles, were reliably detected by digital radiography.
Views and Visions of the Tropical World (2005)

Abstract This book brings together contributors from various disciplinary backgrounds—principally, art history, cultural geography, literature, imperial history, and the history of science—to consider the visualization of the tropical world. This book is especially concerned with the ways in which “the tropics” have been represented as something to be seen—a view to be had or a vision to be experienced. In the book, spaces of the tropics have been imagined in a wide variety of ways, within diverse forms of writing, sketching, mapping, charting, panoramas, painting, and photography. In very general terms, the words “view” and “vision” are used here to capture two contrasting modalities through which the tropics have been pictured. The view emerged in the context of a topographical aesthetic in which landscapes are depicted at a distance, their surface features translated into a recognizable visual code. In this very general sense, the term belongs equally to landscape sketching, coastal survey, and terrestrial mapping; it is part of a topographic culture in which the world is apprehended from afar.
In Vivo Evaluation of Adipose-Derived Stromal Cells Delivered with a Nanofiber Scaffold for Tendon-to-Bone Repair (2015)

Rotator cuff tears are common and cause a great deal of lost productivity, pain, and disability. Tears are typically repaired by suturing the tendon back to its bony attachment. Unfortunately, the structural (e.g., aligned collagen) and compositional (e.g., a gradient in mineral) elements that produce a robust attachment in the healthy tissue are not regenerated during healing, and the repair is prone to failure. Two features of the failed healing response are deposition of poorly aligned scar tissue and loss of bone at the repair site. Therefore, the objective of the current study was to improve tendon-to-bone healing by promoting aligned collagen deposition and increased bone formation using a biomimetic scaffold seeded with pluripotent cells. An aligned nanofibrous poly(lactic-co-glycolic acid) scaffold with a gradient in mineral content was seeded with adipose-derived stromal cells (ASCs) and implanted at the repair site of a rat rotator cuff model. In one group, cells were transduced with the osteogenic factor bone morphogenetic protein 2 (BMP2). The healing response was examined in four groups (suture only, acellular scaffold, cellular scaffold, and cellular BMP2 scaffold) using histologic, bone morphology, and biomechanical outcomes at 14, 28, and 56 days. Histologically, the healing interface was dominated by a fibrovascular scar response in all groups. The acellular scaffold group showed a delayed healing response compared to the other groups. When examining bone morphology parameters, bone loss was evident in the cellular BMP2 group compared to other groups at 28 days. When examining repair-site mechanical properties, strength and modulus were decreased in the cellular BMP2 groups compared to other groups at 28 and 56 days. These results indicated that tendon-to-bone healing in this animal model was dominated by scar formation, preventing any positive effects of the implanted biomimetic scaffold. Furthermore, cells transduced with the osteogenic factor BMP2 led to impaired healing, suggesting that this growth factor should not be used in the tendon-to-bone repair setting.
Well controlled multiple resistive switching states in the Al local doped HfO2 resistive random access memory device (2013)

The resistive switching behaviors in the sandwiched Ti/HfO2/Pt devices with different doping condition were systematically investigated. We show that, comparing with the undoped and the Al layer doped HfO2 devices, significant improvement of switching characteristics is achieved in the Al local doped HfO2 device, including uniformity, reliability, and operation current. As a result, well controlled multiple switching states are obtained in the local doping device by modulating the set current compliance or the maximal reset voltage, respectively. Our results suggest that the switching characteristics of HfO2 device are very closely related to the inducement and controlling of conductive filaments’ growth in the dielectric layer, which can be considered in the optimization of resistive random access memory device design.
ChemInform Abstract: A One‐Step Transformation of (S)‐1‐Benzoyl‐3‐ [(E)‐dimethylaminomethylidene]‐5‐methoxycarbonylpyrrolidin‐2‐one into Quinolizinyl‐ and 2H‐2‐Pyranonyl‐Substituted Alanine Derivatives. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
VHDL Environment for Floating Point Arithmetic Logic Unit-ALU Design and Simulation (2011)

VHDL environment for floating point arithmetic and logic unit design using pipelining is introduced; the novelty in the ALU design with pipelining provides a high performance ALU to execute multiple instructions simultaneously. In top-down design approach, four arithmetic modules, addition, subtraction, multiplication and division are combined to form a floating point ALU unit. Each module is divided into sub- modules with two selection bits are combined to select a particular operation. Each module is independent to each other. The modules are realized and validated using VHDL simulation in the Xilinx12.1i software.
Effect of Guglielmi detachable coils on intraaneurysmal flow: experimental study in canines. (2002)

In this model, intraaneurysmal blood flow can be evaluated with thermodilution. GDC coil placement significantly reduces blood flow in aneurysms.
<title>Recent advances in solar radiometry at the National Renewable Energy Laboratory</title> (1993)

Specialized instrumentation is being developed at the National Renewable Energy Laboratory (NREL) for the measurement of both outdoor and simulated solar radiation. Examples include the Atmospheric Optical Calibration System (AOCS), solar ultraviolet (UV) spectroradiometers, and spectroradiometers for measuring spectra of pulsed solar simulators used in the testing of advanced solar photovoltaic devices.