gebhart/patrepeval huggingface dataset:
DeepRMSA: A Deep Reinforcement Learning Framework for Routing, Modulation and Spectrum Assignment in Elastic Optical Networks (2019)

This paper proposes DeepRMSA, a deep reinforcement learning framework for routing, modulation and spectrum assignment (RMSA) in elastic optical networks (EONs). DeepRMSA learns the correct online RMSA policies by parameterizing the policies with deep neural networks (DNNs) that can sense complex EON states. The DNNs are trained with experiences of dynamic lightpath provisioning. We first modify the asynchronous advantage actor-critic algorithm and present an episode-based training mechanism for DeepRMSA, namely, DeepRMSA-EP. DeepRMSA-EP divides the dynamic provisioning process into multiple episodes (each containing the servicing of a fixed number of lightpath requests) and performs training by the end of each episode. The optimization target of DeepRMSA-EP at each step of servicing a request is to maximize the cumulative reward within the rest of the episode. Thus, we obviate the need for estimating the rewards related to unknown future states. To overcome the instability issue in the training of DeepRMSA-EP due to the oscillations of cumulative rewards, we further propose a window-based flexible training mechanism, i.e., DeepRMSA-FLX. DeepRMSA-FLX attempts to smooth out the oscillations by defining the optimization scope at each step as a sliding window, and ensuring that the cumulative rewards always include rewards from a fixed number of requests. Evaluations with the two sample topologies show that DeepRMSA-FLX can effectively stabilize the training while achieving blocking probability reductions of more than 20.3% and 14.3%, when compared with the baselines.
Psychosocial aspects of genetic screening of pregnant women and newborns: a systematic review (2004)

The results of this review have many implications for the work of the National Screening Committee. The most pressing of these, in order of priority, relate to: the inadequacy of current procedures for achieving informed consent; the cost of providing a satisfactory service; the unmet needs of 'false-positives', and the unmet needs of women's partners, particularly in carrier screening. It is suggested that research is conducted on the above four topics in order to fill gaps in the evidence base that relate to screening technologies which have been available for many years. In addition, future screening programmes will create a new list of research questions, based on the same main agenda but applied to new areas, for example, new conditions such as haemoglobinopathies and fragile X syndrome; new client groups such as young women and minority ethnic groups; and new testing modalities such as ultrasound.
BIOCONTROL OF BOTRYTIS CINEREA ON STRAWBERRY FRUIT BY PLANT GROWTH PROMOTING BACTERIA (2011)

In the present study, a total of 186 bacterial strains isolated from various soil sources and plant species from Eastern Anatolia region in Turkey were evaluated for their ability to suppress gray mold (Botrytis cinerea Pers. ex Fr.) occurred on strawberry cv. Fern. Among 186 bacterial strains, 36 were found effective to inhibit of development B. cinerea under in vitro conditions, and thirteen of them which have greater inhibition zone were selected as biocontrol agent. These antagonistic strains were identified as Bacillus lentimorbus, B. megaterium, B. pumilis, B. subtilis, Enterobacter intermedius, Kurthia sibirica, Paenibacillus polymyxa and Pantoea agglomerans. The inhibition zones among bacteria against B. cinerea were found between 0.50 (Bacillus C6, Brevibacterium MFD-47 and Pantoea MFD-232) and 3.75 cm (Enterobacter MFD-81) in vitro. The strawberry fruits were inoculated with B. cinerea in laboratory trials and Bacillus MFDU-2 (14.41 mm) was found more effective to prevent mycelial development on strawberry fruits in comparison to the control (19.20 mm). In terms of conidia germination on strawberry fruits, the lowest disease incidence was observed in MFD-45 treatment (20.8%), while disease incidence rate for the control was 79.2%. It was shown that antagonistic bacterial strains inhibited B. cinerea and that they have a potential use in sustainable strawberry production.
Serial Multiplication of an Influenza Virus (NWS) in Certain Human Diploid Cell Strains. (1964)

Inoculation with NWS of certain diploid cell strains derived from human embryonic lung resulted in production of infective and hemagglutinating virus coincident with induction of CPE. Diploid strains varied in susceptibility to infection with NWS virus. Influenza virus strains other than NWS did not induce the formation of infective virus and were not serially propagable in diploid cultures. However, in high concentration other influenza viruses induced CPE and the formation of incomplete virus.
Antibacterial activity of selected Malaysian honey (2013)

Malaysian honey, namely gelam, kelulut and tualang, have high antibacterial potency derived from total and non-peroxide activities, which implies that both peroxide and other constituents are mutually important as contributing factors to the antibacterial property of honey.
Ephrin-B1 regulates the adult diastolic function through a late postnatal maturation of cardiomyocyte surface crests (2023)

The rod-shaped adult cardiomyocyte (CM) harbors a unique architecture of its lateral surface with periodic crests, relying on the presence of subsarcolemmal mitochondria (SSM) with unknown role. Here, we investigated the development and functional role of CM crests during the postnatal period. We found in rodents that CM crest maturation occurs late between postnatal day 20 (P20) and P60 through both SSM biogenesis, swelling and crest-crest lateral interactions between adjacent CM, promoting tissue compaction. At the functional level, we showed that the P20-P60 period is dedicated to the improvement of relaxation. Interestingly, crest maturation specifically contributes to an atypical CM hypertrophy of its short axis, without myofibril addition, but relying on CM lateral stretching. Mechanistically, using constitutive and conditional CM-specific knock-out mice, we identified ephrin-B1, a lateral membrane stabilizer, as a molecular determinant of P20-P60 crest maturation, governing both the CM lateral stretch and the diastolic function, thus highly suggesting a link between crest maturity and diastole. Remarkably, while young adult CM-specific Efnb1 KO mice essentially exhibit an impairment of the ventricular diastole with preserved ejection fraction and exercise intolerance, they progressively switch toward systolic heart failure with 100% KO mice dying after 13 months, indicative of a critical role of CM-ephrin-B1 in the adult heart function. This study highlights the molecular determinants and the biological implication of a new late P20-P60 postnatal developmental stage of the heart in rodents during which, in part, ephrin-B1 specifically regulates the maturation of the CM surface crests and of the diastolic function.
An overview of vertebrate mineralization with emphasis on collagen-mineral interaction. (1999)

The nucleation, growth, and development of mineral crystals through their interaction principally with collagen in normal bone and calcifying tendon have been elaborated by applying a number of different techniques for analysis of the inorganic and organic constituents of these tissues. The methods have included conventional and high voltage electron microscopy, electron diffraction, microscopic tomography and 3D image reconstruction, and atomic force microscopy. This summary presents results of these studies that have now characterized the size, shape, and aspects of the chemical nature of the crystals as well as their orientation, alignment, location, and distribution with respect to collagen. These data have provided the means for understanding more completely the formation and strength of the collagen-mineral composite present in most vertebrate calcifying tissues and, from that information, a basis for the adaptation of such tissues under mechanical constraints. In the context of the latter point, other data are given showing effects on collagen in bone cell cultures subjected to the unloading parameters of spaceflight. Implications of these results may be particularly relevant to explaining loss of bone by humans and other vertebrate animals during missions in space, during situations of extended fracture healing, long-term bedrest, physical immobilization, and related conditions. In a broader sense, the data speak to the response of bone and mineralized vertebrate tissues to changes in gravitational loading and applied mechanical forces in general.
The Phytochemistry and Pharmacology of Butia sp.: A Systematic Review and an Overview of the Technological Monitoring Process (2017)

The Butia sp. are native South America trees, whose fruits are consumed in natura and have significant biological properties; however, trees of this genus plant are in danger of extinction. A systematic review of the literature and a technological overview were carried out to summarize the available evidence on the therapeutic uses and the phytochemical compounds of Butia sp. The following electronic databases were researched: MedLine (PubMed), Web of Science, Scopus, Scielo, and the gray literature. Furthermore, the online system such as the US Patent and Trademark Office, Espacenet, National Institute of Industrial Property, and Google Patents were accessed to obtain patent data. The inclusion criteria were articles that describe either the therapeutic uses of Butia sp. (antimicrobial activity, antioxidant activity, anti-inflammatory activity, antineoplastic activity) or studies describing phytochemical compounds of Butia sp. A limited amount of manual search was also undertaken. Reference lists were scanned to identify other relevant studies, and requests for unpublished data were conducted to people working in the field. Among 12 papers and 14 patents, 9 complete texts of scientific articles and 1 patent were scrutinised by two reviewers. We concluded that Butia has shown some antioxidant, anti-inflammatory, and antimicrobial activity, and its use could have important implications for future therapeutic uses. Although there is evidence of pharmacological potential from in vitro studies, clinical studies must be conducted to confirm the effectiveness of Butia sp. The evidence of its therapeutic uses has not been extensively studied yet, and the available evidence still needs further confirmation. Copyright © 2017 John Wiley & Sons, Ltd.
Major oncogenes and tumor suppressor genes involved in epithelial ovarian cancer (review). (2000)

Ovarian cancer remains the leading cause of death from gynecologic malignancy in Western countries. This cancer results from a succession of genetic alterations involving oncogenes and tumor suppressor genes which have a critical role in normal cell growth regulation. Mutations and/or overexpression of three oncogenes, HER-2/neu, c-myc and K-ras, and of the tumor suppressor gene p53, have frequently been observed in sporadic ovarian cancer. In the context of high risk families, the most frequently involved genes are BRCA1 and BRCA2. We review the function of these different proteins, the incidence of mutations in their genes in carcinogenesis and as potential prognostic factors in sporadic and hereditary ovarian cancer.
Skin Transcriptome of Middle-Aged Women Supplemented With Natural Herbo-mineral Shilajit Shows Induction of Microvascular and Extracellular Matrix Mechanisms (2019)

AbstractObjective: Shilajit is a pale-brown to blackish-brown organic mineral substance available from Himalayan rocks. We demonstrated that in type I obese humans, shilajit supplementation signifi...
The Grouping Genetic Algorithm: An efficient method to design assembly lines (2000)

Chapter 13
Impact of film structure on damage to low-kSiOCH film during plasma exposure (2009)

We investigated the resistance of a low-k SiOCH film structure to plasma-irradiation damage by comparing films deposited by neutral-beam enhanced chemical-vapour-deposition (NBECVD) and conventional plasma CVD techniques to clarify the degradation mechanism of the dielectric constant in low dielectric SiOCH film during plasma etching. We found that the durability of a low-k SiOCH film structure to plasma irradiation strongly depended on the kind of Si–O structure the film had. In particular, a linear Si–O structure was less affected by plasma exposure than were network/cage Si–O structures because of the small amount of stress in the O–Si–O structure. In addition, this linear Si–O structure helped to reduce the number of methyl groups removed from the film by plasma irradiation, which preserved the dielectric constant. Since the NBECVD technique can generate a low-k SiOCH film with more linear Si–O structures than conventional plasma CVD, a film made through this technique has very strong plasma durability.
SAR Correlation Tomography for Vegetation Analysis with ESA TomoSense Data (2022)

This paper illustrates the potential of correlation SAR tomography for monitoring forested areas. Correlation SAR tomography requires several pairs of interferometric images rather than a full stack as for standard SAR tomography. As a consequence, constrains for the survey are relaxed and cheaper space-borne system can be designed. A promising configuration is represented by a space-borne SAR platform supported by a receiver-only satellite providing the second image. Experiments were carried out by means of two airborne SAR sensors flying in close formation in the framework of the new ESA TomoSense campaign. Data were acquired over the Kermeter forest (Germany) and pre-processed by MetaSensing. TomoSense campaign features multi frequency, multi polarimetric, opposite views tomographic SAR acquisitions. Ad-hoc calibration and tomographic algorithms were successfully developed and applied to this dataset. They are here presented together with some estimates of physical parameters of the forest under observation resulting from L-band data. Estimates are compared to external LiDAR measurements showing very good agreement.
On the Optimal Filters for a Fixed-Range Radar (1972)

The jointly optimal filters of a filter-sampler-filter system, representative of a fixed-range radar, are shown to each have impulse-response functions of the form a · cos(at), 0 ≤ t ≤ π/2a.
Identification of Initiation Sites for DNA Replication in the Human dnmt1 (DNA-methyltransferase) Locus (1999)

Vertebrates have developed multiple mechanisms to coordinate the replication of epigenetic and genetic information. Dnmt1 encodes the maintenance enzyme DNA-methyltransferase, which is responsible for propagating the DNA methylation pattern and the epigenetic information that it encodes during replication. Direct sequence analysis and bisulfite mapping of the 5' region of DNA-methyltransferase 1 (dnmt1) have indicated the presence of many sequence elements associated with previously characterized origins of DNA replication. This study tests the hypothesis that the dnmt1 region containing these elements is an origin of replication in human cells. First, we demonstrate that a vector containing this dnmt1 sequence is able to support autonomous replication when transfected into HeLa cells. Second, using a gel retardation assay, we show that it contains a site for binding of origin-rich sequences binding activity, a recently purified replication protein. Finally, using competitive polymerase chain reaction, we show that replication initiates in this region in vivo. Based on these lines of evidence, we propose that initiation sites for DNA replication are located between the first intron and exon 7 of the human dnmt1 locus.
BARE retrotransposons produce multiple groups of rarely polyadenylated transcripts from two differentially regulated promoters (2008)

The BARE retrotransposon family comprises more than 10(4) copies in the barley (Hordeum vulgare) genome. The element is bounded by long terminal repeats (LTRs, 1829 bp) containing promoters and RNA-processing motifs required for retrotransposon replication. Members of the BARE1 subfamily are transcribed, translated, and form virus-like particles. Very similar retrotransposons are expressed as RNA and protein in other cereals and grasses. The BARE2 subfamily is, however, non-autonomous because it cannot produce the GAG capsid protein. The pattern of plant development implies that inheritance of integrated copies should critically depend, in the first instance, on cell-specific and tissue-specific expression patterns. We examined transcription of BARE within different barley tissues and analyzed the promoter function of the BARE LTR. The two promoters of the LTR vary independently in activity by tissue. In embryos TATA1 was almost inactive, whereas transcription in callus appears to be less tightly regulated than in other tissues. Deletion analyses of the LTR uncovered strong positive and negative regulatory elements. The promoters produce multiple groups of transcripts that are distinct by their start and stop points, by their sequences, and by whether they are polyadenylated. Some of these groups do not share the common end structures needed for template switching during replication. Only about 15% of BARE transcripts are polyadenylated. The data suggest that distinct subfamilies of transcripts may play independent roles in providing the proteins and replication templates for the BARE retrotransposon life cycle.
Modulation of the time course of fast EPSCs and glutamate channel kinetics by aniracetam (1991)

It is generally accepted that glutamate serves as the neurotransmitter at most excitatory synapses in the mammalian central nervous system (CNS). Synaptic release of glutamate may trigger a fast and a slow excitatory postsynaptic current (EPSC). The slow EPSC is mediated by N-methyl-D-aspartate (NMDA) receptor channels, whereas the fast EPSC is mediated by non-NMDA receptor channels. The nootropic agent aniracetam selectively and reversibly slows the desensitization kinetics of non-NMDA channels and lengthens their single-channel open times. Antiracetam also modulates the kinetics of the fast EPSC in a manner that mirrors its action on the kinetics of the non-NMDA channels. These results support the hypothesis that the properties of the non-NMDA glutamate channels rather than the rate of neurotransmitter clearance are the primary determinants of the kinetics of the fast EPSC in the mammalian CNS.
Two human tumors with high basement membrane-producing potential (1988)

Two human tumors, an adenoid cystic carcinoma and a yolk sac tumor, were found by immunocytochemical, ultrastructural, and biochemical studies to contain abundant basement membrane matrix in contrast to the vast majority of human tumors which contained either an absent or scant basement membrane matrix. These tumors were established as xenografts in athymic (nude) mice. Both xenografts maintained characteristic histologic features, immunocytochemical localization of basement membrane components, and reasonable yields of native laminin and Type IV collagen throughout three successive transplant generations. Although only a small fraction of the yield of that of the murine Engelbreth-Holm, Swarm (EHS) sarcoma, the yield of the human basement membrane-producing tumors could be increased by rendering the mice lathyritic. The human basement membrane proteins so extracted were identical on sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) to their murine counterparts. These human tumors then represent a potential source of human basement membrane proteins.
Recovery of Sparse Translation-Invariant Signals With Continuous Basis Pursuit (2011)

We consider the problem of decomposing a signal into a linear combination of features, each a continuously translated version of one of a small set of elementary features. Although these constituents are drawn from a continuous family, most current signal decomposition methods rely on a finite dictionary of discrete examples selected from this family (e.g., shifted copies of a set of basic waveforms), and apply sparse optimization methods to select and solve for the relevant coefficients. Here, we generate a dictionary that includes auxiliary interpolation functions that approximate translates of features via adjustment of their coefficients. We formulate a constrained convex optimization problem, in which the full set of dictionary coefficients represents a linear approximation of the signal, the auxiliary coefficients are constrained so as to only represent translated features, and sparsity is imposed on the primary coefficients using an L1 penalty. The <i>basis pursuit denoising</i> (BP) method may be seen as a special case, in which the auxiliary interpolation functions are omitted, and we thus refer to our methodology as <i>continuous basis pursuit</i> (CBP). We develop two implementations of CBP for a one-dimensional translation-invariant source, one using a first-order Taylor approximation, and another using a form of trigonometric spline. We examine the tradeoff between sparsity and signal reconstruction accuracy in these methods, demonstrating empirically that trigonometric CBP substantially outperforms Taylor CBP, which in turn offers substantial gains over ordinary BP. In addition, the CBP bases can generally achieve equally good or better approximations with much coarser sampling than BP, leading to a reduction in dictionary dimensionality.
Urinary bladder herniation through inguinal ring in a female cat. (2018)

A 7-month-old spayed female domestic shorthair cat was referred for lethargy, stranguria, and a fluctuant mass of varying size in the right inguinal region. Computed tomographic imaging revealed the urinary bladder partially herniated through the right inguinal canal. Primary herniorrhaphy was performed and re-placement of the urinary bladder was confirmed <i>via</i> laparotomy.
JA-POLS: A Moving-Camera Background Model via Joint Alignment and Partially-Overlapping Local Subspaces (2020)

Background models are widely used in computer vision. While successful Static-camera Background (SCB) models exist, Moving-camera Background (MCB) models are limited. Seemingly, there is a straightforward solution: 1) align the video frames; 2) learn an SCB model; 3) warp either original or previously-unseen frames toward the model. This approach, however, has drawbacks, especially when the accumulative camera motion is large and/or the video is long. Here we propose a purely-2D unsupervised modular method that systematically eliminates those issues. First, to estimate warps in the original video, we solve a joint-alignment problem while leveraging a certifiably-correct initialization. Next, we learn both multiple partially-overlapping local subspaces and how to predict alignments. Lastly, in test time, we warp a previously-unseen frame, based on the prediction, and project it on a subset of those subspaces to obtain a background/foreground separation. We show the method handles even large scenes with a relatively-free camera motion (provided the camera-to-scene distance does not change much) and that it not only yields State-of-the-Art results on the original video but also generalizes gracefully to previously-unseen videos of the same scene. Our code is available at https://github.com/BGU-CS-VIL/JA-POLS.