gebhart/patrepeval huggingface dataset:
Targeting the Bet-Hedging Strategy with an Inhibitor of Bacterial Efflux Capacity Enhances Antibiotic Efficiency and Ameliorates Bacterial Persistence In Vitro (2022)

Persistence is a bet-hedging strategy in bacterial populations that increases antibiotic tolerance and leads to the establishment of latent infections. In this study, we demonstrated that a synthetic non-toxic taxane-based reversal agent (tRA), developed as an inhibitor of ABC transporter systems in mammalian cancer cells, enhanced antibiotic killing of persister populations from different pathogens, including <i>Burkholderia</i>, <i>Pseudomonas</i>, <i>Francisella</i>, and <i>Yersinia</i>. Acting as an inhibitor of bacterial efflux at 100 nM, tRA99020 enhanced antibiotic efficiency and suppressed the production of natural products of <i>Burkholderia</i> species polyketide synthase (PKS) function. We demonstrate that the metabolites produced by PKS in response to stress by different antibiotics act as inhibitors of mammalian histone deacetylase activity and stimulate cell death. Applying a single-molecule fluorescence in situ hybridization (smFISH) assay, we analyzed on a single-cell level the activation profiles of the persistence regulating pks gene in <i>Burkholderia thailandensis</i> treated with tRA99020 and antibiotics. We posit that a multi-pronged approach encompassing antibiotic therapies and inhibition of efflux systems and fatty acid catabolism will be required for efficient eradication of persistent bacterial populations.
Permission Marketing: Turning Strangers Into Friends And Friends Into Customers (1999)

The man Business Week calls ultimate entrepreneur for the Information Age explains Marketing the groundbreaking concept that enables marketers to shape their message so that consumers will willingly accept it. Whether it is the TV commercial that breaks into our favorite program, or the telemarketing phone call that disrupts a family dinner, traditional advertising is based on the hope of snatching our attention away from whatever we are doing. Seth Godin calls this Interruption Marketing, and, as companies are discovering, it no longer works. Instead of annoying potential customers by interrupting their most coveted commodity time Marketing offers consumers incentives to accept advertising voluntarily. Now this Internet pioneer introduces a fundamentally different way of thinking about advertising products and services. By reaching out only to those individuals who have signaled an interest in learning more about a product, Permission Marketing enables companies to develop long-term relationships with customers, create trust, build brand awareness -- and greatly improve the chances of making a sale.
Supplementary Table 1 from p53 Negatively Regulates the Hepatoma Growth Factor HDGF (2023)

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PSIV-19 Evaluation of Enogen® high amylase corn on growth performance and carcass characteristics of finishing pigs (2020)

Abstract A total of 288 pigs (Line 600 241, DNA, Columbus, NE; initially 41.6 kg) were used in an 82-d trial to determine if replacing conventional yellow dent corn with high amylase corn (Enogen®, Syngenta Seeds, LLC, Downers Grove, IL) in diets with or without distillers dried grains with solubles (DDGS) influences growth performance and carcass characteristics. Diets were arranged in a 2 × 2 factorial with 2 corn sources (yellow dent or high amylase) and 2 levels of DDGS (0 or 25%). Experimental diets were fed in meal form in 3 phases: d 0 to 29, 29 to 47, and 47 to 82. There were 9 pens/treatment each containing an equal number of barrows and gilts. Pigs were weighed approximately every 2 wk and at the beginning of each phase. On d 82, pigs were transported to a commercial packing plant for processing and carcass data collection. Data were analyzed using PROC GLIMMIX procedure of SAS with pen as the experimental unit. There were no interactions (P &amp;gt; 0.05) between corn source and DDGS inclusion for overall performance or carcass characteristics. Overall, average daily gain (ADG) was marginally greater (P &amp;lt; 0.089) for pigs fed high amylase than yellow dent corn with no evidence (P &amp;gt; 0.196) for difference in feed intake, feed efficiency (G/F), hot carcass weight (HCW), or other carcass traits. Addition of DDGS resulted in decreased (P &amp;lt; 0.037) overall ADG and G/F. Pigs fed DDGS had marginally lower (P &amp;lt; 0.071) HCW, less (P &amp;lt; 0.050) backfat, greater (P &amp;lt; 0.026) loin depth, and greater (P &amp;lt; 0.020) percentage lean and iodine values. In summary, high amylase corn tended to improve overall ADG; however, feed efficiency and carcass characteristics were unchanged between corn sources. Consistent with previous research, addition of DDGS decreased ADG and increased IV.
Coagulopathies in chronic kidney disease (2015)

Abstract Coagulation abnormalities are common in chronic kidney disease (CKD). Both haemorrhage and thrombosis are more common than in the general population. Haemorrhage, when it occurs, is associated with increased morbidity and mortality compared to that seen in non-uraemic patients. It is more likely spontaneously, but particularly in association with anti-platelet agents or anticoagulants. The increased risk of both arterial and venous thrombosis occurs in part because of the increase prevalence of traditional risk factors for thrombosis in CKD, in part because of the specific problems associated with nephrotic syndrome, and also because of specific putative prothrombotic factors associated with CKD, such as increased levels of coagulation factors and altered platelet function associated with uraemia. Two syndromes, both characterized by intravascular thrombosis can contribute to the development of CKD. The first is antiphospholipid syndrome, due to the presence of antibodies against negatively charged phospholipids, in which thrombosis of the renal vasculature is relatively common. The second is a group of conditions, the thrombotic microangiopathies, in which inherited or acquired deficiencies of ADAMTS13, antiphospholipid antibodies, or pathological endothelial cell activation in renal vessels, sometimes due to functional deficiencies of one or more proteins regulating coagulation or complement activation, leads to acute renal dysfunction associated with anaemia.
Antimicrobic features of phenolic lipids (2010)

The connection between the efficiency of phenolic lipids (PL) and their hydrophobic property (solubility) and hydrophobic property of microorganisms' cell structure is shown. The mixture of amphiphilic di(oxiphenil)-phenil-methanes, which act bacteriostatically under 15 mg/l, possesses maximal efficiency against Staphylococcus aureus. Against Mycobacterium smegmatis with hydrophobic cell wall, hydrophobic 2,4-dialkylocibenzol 70 mg/l was the most effective. Hexylresorcin (HR) stops the development of gram-positive bacteria in concentrations 20-50 mg/l, that of gram-negative bacteria in concentration 65 mg/l, that of M. smegmatis at 70 mg/l, and that of yeast and fungi at 300 mg/l. HR prevails bacteria spores germination in the concentration 25-100 mg/l. The dependence of antibacterial action of isomers and homologues of alkylresorcins on their structure--number, position, and length of alkyl substituents--is studied.
The relative bioavailability of paracetamol and codeine after oral administration of a combination of buclizine, paracetamol and codeine, with or without docusate, and of paracetamol alone in healthy volunteers (1985)

A randomized, double-blind, crossover study was carried out in 10 healthy volunteers to investigate whether the inclusion of the wetting agent docusate sodium (10 mg) in a combined oral formulation ('Migraleve') with buclizine hydrochloride (6.25 mg), codeine phosphate (8 mg) and paracetamol (500 mg) had any effect on the bioavailability of the analgesics. On 3 occasions at weekly intervals, the subjects were given 2 tablets of the standard formulation, the combination without docusate or 500 mg paracetamol alone. Blood samples were taken before and at fixed times during the 4 hours after administration of each preparation for estimation of plasma concentrations of paracetamol, by gas-liquid chromatography, and of codeine, by radioimmunoassay. The results showed that there were no significant differences between the mean paracetamol concentrations achieved after administration of each of the 3 preparations at any of the time points. Peak paracetamol plasma concentrations were 11.25 +/- 1.74 micrograms/ml at 0.5 hours, 9.6 +/- 1.04 micrograms/ml at 0.75 hours, and 9.53 +/- 1.66 micrograms/ml at 0.5 hours, respectively, after the standard formulation, the combination without docusate, and paracetamol alone. Mean elimination half-lives for paracetamol were 2.83 +/- 0.51, 1.92 +/- 0.20 and 2.49 +/- 0.46 hours, respectively, and the differences were not significant. The difference between mean plasma concentrations of codeine after the two preparations including this analgesic bordered on significance at 3 hours and was significant at 4 hours, but the areas under the curve were not significantly different. Peak codeine plasma concentrations after the standard formulation were 42.1 +/- 9.4 ng/ml at 0.75 hours compared with 36.9 +/- 3.4 ng/ml at 1.5 hours after the combination without docusate.(ABSTRACT TRUNCATED AT 250 WORDS)
Reducing excessive journaling overhead in mobile devices with small-sized NVRAM (2014)

The excessive journaling degrades the performance and shortens the lifetime of NAND flash storage in mobile devices. We propose a novel journaling scheme that resolves this problem by using small-sized NVRAM efficiently. Experimental results show that our proposed scheme outperforms EXT4 by up to 16.8 times for synthetic workloads. Also, for TPC-C SQLite benchmark, it enhances the transaction throughput by 20% and reduces the number of journal writes by 58% with only 16 MB NVRAM.
A featureless wideband Gaussian noise signaling modem employing acoustic charge transport (ACT) technology (2002)

Low probability of intercept communication schemes are crucial in scenarios where transmitter covertness must be maintained. Popular efforts to improve covertness are known to employ or enhance featureless qualities of wideband spread spectrum waveforms. The authors implement the strategy of modulating an already featureless wideband waveform - average white Gaussian noise - such that the modulation waveform remains featureless while transmitting binary data. The technique employed is adapted directly from the theoretical description given by Cooper at MILCOM '82. A working hardware model for a featureless wideband Gaussian noise signaling binary data modem has been prepared using standard ACT programmable transversal filters (PTFs). A transmitted reference modulation scheme is employed which enables decoding at the receiver without phase locked carrier recovery or code synchronization. ACT PTFs are used at the receiver to recorrelate the reference signal with the modulated signal. Correlation sequences are fully programmable.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Tautomerism and Reactivity in Heterocyclic N-Oxides. A Spectroscopic and Theoretical Study of Benzimidazole N-Oxide Derivatives (N-Hydroxybenzimidazoles) (2004)

The tautomeric forms of benzimidazole N-oxide derivatives in solution were studied using nuclear magnetic resonance (NMR) techniques. Further insight into the molecular structures was provided by theoretical calculations using density functional theory (DFT). In the gas phase the N-hydroxy tautomer was more stable than the N-oxide, whereas in solution the stabilization of one form or the other depended on hydrogen bond formation involving the N-hydroxy/N-oxide moiety. Derivative 4 (n-butyl-5-nitrobenzimidazole-2-carboxamide 3-oxide), having a 2-carboxamide moiety, was the only compound studied present as a mixture of tautomers, the N-oxide being the predominant one. This was assigned to the formation of an internal hydrogen bond between the N-oxide group and the amide hydrogen atom. The tautomeric form present in the solid state was studied for derivative 1 (ethyl-5-nitrobenzimidazole-2-carboxylate 3-oxide) and was conclusively assigned by X-ray diffraction techniques to the N-hydroxy tautomer. In the crystal a strong O−H···N intermolecular bond gives rise to supramolecular polymeric chains in the lattice. This strong interaction was also seen in the infrared spectrum and was assigned to two broad bands at 2367 and 2526 cm-1. The vibrational spectrum was satisfactorily described by DFT calculations and an example of this is the prediction of the band corresponding to the N−O stretching (N-oxide) just 1% lower than the experimental value. Uncorrelated calculations (HF) were not able to give an unambiguous assignment of this band. The reaction of derivative 1 against different kinds of electrophiles, hard and soft, led only to O-substituted products. This result was explained in terms of the HSAB theory using a local−global approach.
Artificial neural network for bifurcating phenomena modelled by nonlinear parametrized PDEs (2021)

Abstract The aim of this work [1] is to show the applicability of the Reduced Basis (RB) model reduction and Artificial Neural Network (ANN) dealing with parametrized Partial Differential Equations (PDEs) in nonlinear systems undergoing bifurcations. Bifurcation analysis, i.e., following the different bifurcating branches due to the non‐uniqueness of the solution, as well as determining the bifurcation points themselves, are complex computational tasks. Reduced Order Models (ROM) and Machine Learning (ML) techniques can potentially reduce the computational burden by several orders of magnitude. Models describing bifurcating phenomena arising in several fields with interesting applications, from continuum to quantum mechanics passing through fluid dynamics [2–4]. Following the approach in [5], we analyzed different bifurcating test cases where both physical and geometrical parameters were considered. In particular, we studied the Navier‐Stokes equations for a viscous, steady and incompressible flow in a planar straight channel with a narrow inlet. We reconstructed the branching solutions and explored a new empirical strategy in order to employ the RB and ANN for an efficient detection of the critical points. All the simulations were performed within the open source software FEniCS and RBniCS for the ROM, while we chose PyTorch to construct the neural network.
Gene co-expression networks from RNA sequencing of dairy cattle identifies genes and pathways affecting feed efficiency (2018)

The present study provides new information on the biological functions in liver that are potentially involved in controlling feed efficiency. The hub genes and upstream regulators (ATP7b, IFNG and IL10RA) involved in these functions are potential candidate genes for the development of new biomarkers. However, the hub genes, upstream regulators and pathways involved in the co-expressed networks were different in both breeds. Hence, additional studies are required to investigate and confirm these findings prior to their use as candidate genes.
Platelet‐rich plasma intra‐articular injections for cartilage degeneration and osteoarthritis: single‐ versus double‐spinning approach (2011)

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Meditation and the Wandering Mind: A Theoretical Framework of Underlying Neurocognitive Mechanisms (2020)

During the practice of meditation, the tendency of the mind to wander away from the object of focus is ubiquitous. The occurrence of mind wandering in the context of meditation provides individuals a unique and intimate opportunity to closely examine the nature of the wandering mind by cultivating an awareness of ongoing thought patterns, while simultaneously aiming to cultivate equanimity (evenness of temper or disposition) and compassion toward the content of thoughts, interpretations, and bodily sensations. In this article we provide a theoretical framework that highlights the neurocognitive mechanisms by which contemplative practices influence the neural and phenomenological processes underlying spontaneous thought. Our theoretical model focuses on several converging mechanisms: the role of meta-awareness in facilitating an increased moment-to-moment awareness of spontaneous thought processes, the effects of meditation practice on key structures underlying both the top-down cognitive processes and bottom-up sensory processes implicated in attention and emotion regulation, and the influence of contemplative practice on the neural substrates underlying perception and perceptual decoupling.
Single‐Crystalline Diluted Magnetic Semiconductor GaN:Mn Nanowires (2005)

Single-crystalline diluted magnetic semiconductor GaN:Mn nanowires with controlled Mn concentrations have been successfully synthesized and incorporated into devices. These nanowires exhibit Curie temperatures above room temperature, magnetoresistances near room temperature, and spin-dependent transport. The nanowires are used as building blocks for the fabrication of GaN:Mn/n-SiC based light-emitting diodes.
Leaving group placement to control the stereoselective organoiron-based synthesis of regioisomeric tetrahydrophenanthridine derivatives (1993)

A. McKillop, G. R. Stephenson and M. Tinkl, J. Chem. Soc., Perkin Trans. 1, 1993, 1827 DOI: 10.1039/P19930001827
Molecular Dynamics of Cholesterol in Biomembranes (2019)

Cholesterol is a major component of the mammalian plasma cell membranes and represents about 50% of the membrane lipids. Using molecular dynamics (MD) simulations, it is possible to interpret experimental results of complex membrane systems and gain insight on their interactions at the microscopic level. This chapter presents the development of a force field for cholesterol as well as structural and dynamical aspects of cholesterol in membranes derived from MD simulations. The results are compared with previous experimental and theoretical studies. The parameters for cholesterol were obtained using an automated frequency matching method (AFMM). An initial parameter set was used for minimization and calculation of normal modes with CHARMM. The normal modes obtained were then directly compared with the normal modes calculated from the quantum chemistry methods, used as reference values, employing AFMM.
Unanimous Prediction for 100% Precision with Application to Learning Semantic Mappings (2016)

Can we train a system that, on any new input, either says "don't know" or makes a prediction that is guaranteed to be correct? We answer the question in the affirmative provided our model family is well-specified. Specifically, we introduce the unanimity principle: only predict when all models consistent with the training data predict the same output. We operationalize this principle for semantic parsing, the task of mapping utterances to logical forms. We develop a simple, efficient method that reasons over the infinite set of all consistent models by only checking two of the models. We prove that our method obtains 100% precision even with a modest amount of training data from a possibly adversarial distribution. Empirically, we demonstrate the effectiveness of our approach on the standard GeoQuery dataset.
Control and stabilization of the DOE/NASA Mod-1 two megawatt wind turbine generator (1979)

This paper describes the controls design, performance simulation process and specialized dynamic considerations for the DOE/NASA Mod 1 wind turbine generator (WTG). It shows controls, structural and utility interface considerations of the wind turbine generator and shows how a wind turbine generator can be integrated with a synchronous power system. Differences with respect to fossil or hydro generation and their implications are vital to long-term WTG reliability and availability and acceptance by utilities and consumers. The paper describes the control performance requirements to provide stable pitch and excitation control with drivetrain torsional dynamics, and the control of power swing stability and utility feeder voltage due to wind gusts.
Multiple Linear Regression (2003)

Abstract Multiple regression analysis (MR) is a highly flexible system for examining the relationship of a collection of independent variables (or predictors) to a single dependent variable (or criterion). The independent variables may be quantitative (e.g., personality traits, family income) or categorical (e.g., ethnic group, treatment conditions in an experiment). The present chapter explores ordinary least‐squares regression with a continuous dependent variable. The chapter has two foci: (1) testing of theoretical predictions through multiple regression and (2) identification of problems with implementation of regression analysis, both from the perspectives of model specification and the data themselves. The structure of MR is described, including the regression equation, estimation of partial regression coefficients, measures of overall model fit, and the contribution of individual predictors and sets of predictors to prediction accuracy. The treatment of categorical predictors through effects, dummy, and contrast coding is explained. Polynomial regression for capturing curvilinear relationships is explored. The specification and testing of interactions between continuous variables and between a continuous and a categorical variable are explicated. Assumptions of MR and detection of violations are explained, as is the use of regression diagnostics to identify problematic cases. The chapter illustrates the interplay between theory and empirical findings in the specification, testing, and revision of regression models.
A flexible approach to alliances of complex applications (2003)

Article Free Access Share on A flexible approach to alliances of complex applications Authors: David J. Kasik P.O. Box 3707, Seattle, WA P.O. Box 3707, Seattle, WAView Profile , Conrad E. Kimball P.O. Box 3707, Seattle, WA P.O. Box 3707, Seattle, WAView Profile , Jimmie L. Felt P.O. Box 7730, Wichita, KS P.O. Box 7730, Wichita, KSView Profile , Kenneth B. Frazier P.O. Box 7730, Wichita, KS P.O. Box 7730, Wichita, KSView Profile Authors Info & Claims ICSE '99: Proceedings of the 21st international conference on Software engineeringMay 1999 Pages 23–32https://doi.org/10.1145/302405.302408Published:16 May 1999Publication History 5citation371DownloadsMetricsTotal Citations5Total Downloads371Last 12 Months19Last 6 weeks6 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
A Digitally Reconfigurable Sensor Interface for SOC using Delta-Sigma Modulators (2006)

Many systems on chip (SOC) applications require a mixed signal (analog and digital blocks) design approach. The incorporation of some degree of analog programmability in current digital reconfigurable devices is desired, so the same processor platform can be used in different applications. As mixed signal SOC applications deal with heterogeneous signals (low and high frequency) and signal processing functions (linear and non-linear), the ideal analog interface architecture should be able to manage this heterogeneity. In this paper we propose the use of a constant analog architecture for the SOC analog interface, able to deliver constant performance in this heterogeneous environment. The proposed approach is based on a set composed by a mixer and a band-pass SigmaDelta modulator. Several linear and nonlinear applications can be mapped over the proposed interface architecture for processing analog input signals ranging from low to high frequency. A prototype was built and characterized. Practical results show constant and predictable performance over a large frequency range of the input signal. The achieved results also support the interface potential use for general analog interfacing and programmable signal processing