gebhart/patrepeval huggingface dataset:
Triage of Atypical Squamous Cells of Undetermined Significance With Hybrid Capture II (2003)

In Brief OBJECTIVE To estimate the effectiveness of Hybrid Capture II to predict high-grade cervical intraepithelial neoplasia (CIN) from a cytological cervical sample. Evidence of high-risk human papillomavirus (HPV) was also determined from biopsy samples using the polymerase chain reaction (PCR) for women referred with atypical squamous cells of undetermined significance (ASCUS) Papanicolaou smears. METHODS: We screened 8170 women with Papanicolaou smears, of whom 278 (3.4%) returned ASCUS. All ASCUS cases underwent colposcopy and Hybrid Capture II testing. High-grade CIN biopsy specimens were tested for high-risk HPV by PCR. RESULTS Nearly 30% of ASCUS cases had CIN biopsy results (11.9% showing CIN II or CIN III and 17.6% showing CIN I). Hybrid Capture II positive rates were 93.3% for cases with CIN III, 72.2% for CIN II, and 51.0% for CIN I (P< .001). ASCUS-Premalignant Process Favored cases showed a 28.1% high-grade biopsy rate and a 100% Hybrid Capture II positive rate. For ASCUS-Undefined and ASCUS-Reactive Process Favored cases, Hybrid Capture II returned positive in 90.9% of CIN III and 61.5% of CIN II cases (P < .001). Sixty-nine of 178 (38.8%) patients with no evidence of CIN tested positive for Hybrid Capture II. Human papillomavirus deoxyribonucleic acid (DNA) high-risk subtypes were detected by PCR in the tissue of all high-grade CIN cases with negative Hybrid Capture II results. CONCLUSION Hybrid Capture II returned negative in 25% of cases with biopsy-proven high-grade CIN with associated high-risk HPV DNA by PCR (non-Premalignant ASCUS subset), and positive in 39.3% of cases with normal results; this limits its clinical utility. Hybrid Capture II triage for patients with atypical squamous cells of undetermined significance failed to detect 25% of histologic high-grade dysplasia positive for high-risk human papillomavirus under polymerase chain reaction analysis.
Investigation of phenolic leaf extract of Heimia myrtifolia (Lythraceae): Pharmacological properties (stimulation of mineralization of SaOS-2 osteosarcoma cells) and identification of polyphenols. (2010)

Evaluation of the activity of an aqueous alcoholic extract obtained from the leaves of Heimia myrtifolia (Lythraceae) by determining its stimulating effect on two human osteoblastic cell lines HOS58 and SaOS-2 indicated its potential for use in the prevention and treatment of osteoporosis. In addition, the extract was found to significantly increase the mineralization of cultivated human bone cell SaOS-2, in which a strong dose-dependent increase was observed. A phytochemical investigation of the extract also confirmed that H. myrtifolia is capable of synthesizing and accumulating appreciable amounts of several phenolics, thus leading to the isolation and characterization of sixteen of these constituents. Identified among these isolates were a new natural product, 1,6-di-O-dehydrotrigalloyl-β-D-(4)C(1)-glucopyranose, and a rare natural product (this marks its second report), 5,7,4'-trihydroxy-3-methoxyflavanone (dihydrokaempferol-3-O-methyl ether). Structures of these isolates were fully elucidated on the basis of conventional methods of analysis and confirmed by ESI/MS and (1)H and (13)C-NMR analysis.
Partial Molar Transformation of the Placenta of Presumably Monozygotic Twins (2000)

A pregnancy with one normal female fetus and a placenta that was divided into halves, one normal the other molar, is described. Genetic analysis shows the molar component to be hyperdiploid/tetraploid but having an identical DNA composition as the normal twin. Because there was no trophoblastic proliferation and the hyperdiploid cells were confined to the villous stroma, and because the molar component was still being perfused by diploid vessels from the normal twin, we believe the mole is derived from polyploidization of the mesenchymal epiblast in a monozygotic twin pregnancy.
ChemInform Abstract: DIE KOORDINATIONS‐KATALYSIERTE ORTHO‐HALOGENIERUNG VON AZOBENZOL (1971)

Abstract Die Chlorierung von Azobenzol (I) liefert in Gegenwart von Palladium(II)‐Katalysatoren, z.B. Palladium(II)‐chlorid (II), alle denkbaren ortho‐Halogenierungsprodukte (IV) bis (VIII) mit (VI) als Hauptprodukt.
Heparin‐Induced Thrombocytopenia (2022)

Heparin-induced thrombocytopenia (HIT) is an antibody-mediated adverse effect of heparin. An emerging treatment in addition to alternative anticoagulation in severe HIT is high-dose intravenous immunoglobulin (IvIg), which abruptly inhibits HIT antibody-induced platelet activation. Management of HIT requires knowledge of immunohaematology and haemostasis. The chapter also discusses a HIT-mimicking disorder, vaccine-induced immune thrombotic thrombocytopenia (VITT). VITT pathogenesis involves formation of high-titre platelet-activating anti-PF4 antibodies that also activate neutrophils and monocytes. Two general types of assays detect HIT antibodies: platelet activation (or functional) assays and PF4-dependent immunoassays. The treatment principles for strongly suspected or confirmed HIT are: substitute heparin with a rapidly acting non-heparin anticoagulant, usually in therapeutic doses; minimise prophylactic platelet transfusions; and test for HIT antibodies.
CDK4/6 dual inhibitor abemaciclib demonstrates compelling preclinical activity against esophageal adenocarcinoma: a novel therapeutic option for a deadly disease (2017)

Esophageal adenocarcinoma (EAC) is a deadly disease with limited therapeutic options. In the present study, we determined the preclinical efficacy of CDK4/6 inhibitor abemaciclib for treatment of EAC. <i>In vitro</i>, apoptosis, proliferation, and pathway regulation were evaluated in OE19, OE33, and FLO1 EAC cell lines. <i>In vivo</i>, esophagojejunostomy was performed on rats to induce EAC. At 36 weeks post-surgery, MRI and endoscopic biopsy established baseline tumor volume and molecular correlates, respectively. Next, the study animals were randomized to 26mg/kg intraperitoneal abemaciclib treatment or vehicle control for 28 days. Pre and post treatment MRIs, histopathology, and qRT-PCR were utilized to determine response. Our results demonstrated treatment with abemaciclib lead to increased apoptosis, and decreased proliferation in OE19 (p=0.185), OE33 (p=0.048), and FLO1 (p=0.043) with anticipated downstream molecular inhibition. <i>In vivo</i>, 78.9% of treatment animals demonstrated >20% tumor volume decrease (placebo 0%). Mean tumor volume changed in the treatment arm by -65.5% (placebo +133.5%) (p<0.01), and prevalence changed by -37.5% (placebo +16.7%) (p<0.01). Pre vs post treatment qRT-PCR demonstrated significant inhibition of all downstream molecular correlates. Overall our findings suggest potent antitumor efficacy of abemaciclib against EAC with evident molecular pathway inhibition and reasonable safety, establishing the rationale for future clinical development.
Critical function of Bmx/Etk in ischemia-mediated arteriogenesis and angiogenesis (2006)

Bmx/Etk non-receptor tyrosine protein kinase has been implicated in endothelial cell migration and tube formation in vitro. However, the role of Bmx in vivo is not known. Bmx is highly induced in the vasculature of ischemic hind limbs. We used both mice with a genetic deletion of Bmx (Bmx-KO mice) and transgenic mice expressing a constitutively active form of Bmx under the endothelial Tie-2 enhancer/promoter (Bmx-SK-Tg mice) to study the role of Bmx in ischemia-mediated arteriogenesis/angiogenesis. In response to ischemia, Bmx-KO mice had markedly reduced, whereas Bmx-SK-Tg mice had enhanced, clinical recovery, limb perfusion, and ischemic reserve capacity when compared with nontransgenic control mice. The functional outcomes in these mice were correlated with ischemia-initiated arteriogenesis, capillary formation, and vessel maturation as well as Bmx-dependent expression/activation of TNF receptor 2- and VEGFR2-mediated (TNFR2/VEGFR2-mediated) angiogenic signaling in both hind limb and bone marrow. More importantly, results of bone marrow transplantation studies showed that Bmx in bone marrow-derived cells plays a critical role in the early phase of ischemic tissue remodeling. Our study provides the first demonstration to our knowledge that Bmx in endothelium and bone marrow plays a critical role in arteriogenesis/angiogenesis in vivo and suggests that Bmx may be a novel target for the treatment of vascular diseases such as coronary artery disease and peripheral arterial disease.
A new human plasma cell line, Karpas 620, with translocations involving chromosomes 1, 11 and 14 (1990)

We report here the establishment of a new cell line, Karpas 620 (K620), from the peripheral blood of an elderly woman with an IgG-kappa plasma cell leukaemia (PCL). The line has the same hypotetraploid karyotype as the fresh cells from the patient. The cultured cells have the ultrastructural appearance of plasma cells with abundant rough endoplasmic reticulum (RER) and secrete kappa light chain. They are positive for surface antigens HLA DR, and WR17 (CD 37) and negative for CD1, CD3, CD4 and CD8. Using high resolution (HR) cytogenetic analysis it has been possible to identify all the marker chromosomes including several rearrangements commonly seen in malignancies of B cell lineage. These are a 14q+ marker with a typical 'Burkitt' morphology der(14)(pter----q32.3::8q24.1----qter) but with no reciprocal 8q-, and three translocations involving chromosome 11 at q13 with partners other than chromosome 14, namely 1q32.1, 8q24.22 and 13q14.3. An earlier report of molecular studies on the DNA of K620 has shown a rearrangement near the region on 11q13 designated BCL-1 (Rabbitts et al. 1988). This is the first report of a rearrangement in the region of 11q13 in a cell line originating from a case of plasma cell leukaemia.
Theoretical Analysis of Wankel Engine Combustion (1973)

Abstract A one-dimensional model for. the spark ignition Wankel engine combustion is presented, The model is based on the use of a turbulent diffusivity for heat and mass transfer by which the motion of the finite-thickness, unsteady turbulent flame is calculated. A one-step second order reaction rate equation is used and wall heat transfer losses are included. The instantaneous chamber pressure and the local and instantaneous gas temperature, density, and velocity are calculated. Results are presented for a typical engine design. Initial results of two parametric studies are also reported, but their generalization is not undertaken, at this point, due to the complexity of the process.
How the conservation of charge can lead to a faster-than-c effect: A simple example (2010)

Starting from the continuity equation and Ohm's law, it is demonstrated that electrons incident upon the center of a copper sphere will reappear instantly on the surface of the sphere. Consequences of such superluminal phenomena for general relativity will be discussed.
N-Degradomic Analysis Reveals a Proteolytic Network Processing the Podocyte Cytoskeleton (2017)

Regulated intracellular proteostasis, controlled in part by proteolysis, is essential in maintaining the integrity of podocytes and the glomerular filtration barrier of the kidney. We applied a novel proteomics technology that enables proteome-wide identification, mapping, and quantification of protein N-termini to comprehensively characterize cleaved podocyte proteins in the glomerulus <i>in vivo</i> We found evidence that defined proteolytic cleavage results in various proteoforms of important podocyte proteins, including those of podocin, nephrin, neph1, <i>α</i>-actinin-4, and vimentin. Quantitative mapping of N-termini demonstrated perturbation of protease action during podocyte injury <i>in vitro</i>, including diminished proteolysis of <i>α</i>-actinin-4. Differentially regulated protease substrates comprised cytoskeletal proteins as well as intermediate filaments. Determination of preferential protease motifs during podocyte damage indicated activation of caspase proteases and inhibition of arginine-specific proteases. Several proteolytic processes were clearly site-specific, were conserved across species, and could be confirmed by differential migration behavior of protein fragments in gel electrophoresis. Some of the proteolytic changes discovered <i>in vitro</i> also occurred in two <i>in vivo</i> models of podocyte damage (WT1 heterozygous knockout mice and puromycin aminonucleoside-treated rats). Thus, we provide direct and systems-level evidence that the slit diaphragm and podocyte cytoskeleton are regulated targets of proteolytic modification, which is altered upon podocyte damage.
High quality passivation for heterojunction solar cells by hydrogenated amorphous silicon suboxide films (2008)

In this letter, we report on our investigations of hydrogenated amorphous silicon suboxides (a-SiOx:H) used as a high quality passivation scheme for heterojunction solar cells. The a-SiOx:H films were deposited using high frequency (70MHz) plasma enhanced chemical vapor deposition by decomposition of carbon dioxide, hydrogen, and silane at a substrate temperature of around 155°C. High effective lifetimes of outstanding 4ms on 1Ωcm n-type float-zone material and a surface recombination velocity of ⩽2.6cm∕s have been repeatedly obtained. Optical analysis revealed a distinct decrease of blue light absorption in the a-SiOx:H films compared to commonly used intrinsic amorphous silicon passivation used in heterojunction cells.
Effects of Water-deficit Stress and Gibberellic Acid on Floral Gene Expression and Floral Determinacy in ‘Washington’ Navel Orange (2022)

Effects of water-deficit stress and foliar-applied gibberellic acid (GA 3 ) on ‘Washington’ navel orange ( Citrus sinensis ) floral gene expression and inflorescence number were quantified. Trees subjected to 8 weeks of water-deficit stress [average stem water potential (SWP) −2.86 MPa] followed by 3 weeks of re-irrigation (SWP recovered to &gt; −1.00 MPa) produced more inflorescences in week 11 than trees well-irrigated (SWP &gt; −1.00 MPa) for the full 11 weeks ( P &lt; 0.001). After 8 weeks of water-deficit stress, bud expression of flowering locus t ( FT ), suppressor of overexpression of constans1 ( SOC1 ), leafy ( LFY ), apetala1 ( AP1 ), apetala2 ( AP2 ), sepallata1 ( SEP1 ), pistillata ( PI ), and agamous ( AG ) increased during the re-irrigation period (weeks 9 and 10), but only AP1 , AP2 , SEP1 , PI , and AG expression increased to levels significantly greater than that of well-irrigated trees. Foliar-applied GA 3 (50 mg·L −1 ) in weeks 2 through 8 of the water-deficit stress treatment did not reduce bud FT , SOC1 , or LFY expression, but prevented the upregulation AP1 , AP2, SEP1 , PI , and AG expression that occurred during re-irrigation in water-deficit stressed trees not treated with GA 3 . Applications of GA 3 to water-deficit stressed trees reduced inflorescence number 95% compared with stressed trees without GA 3 . Thus, GA 3 inhibited citrus ( Citrus sp.) floral development in response to water-deficit stress through downregulating AP1 and AP2 expression, which likely led to the failed activation of the downstream floral organ identity genes. The results reported herein suggest that bud determinacy and subsequent floral development in response to water-deficit stress in ‘Washington’ navel orange are controlled by AP1 and AP2 transcript levels, which regulate downstream floral organ identity gene activity and the effect of GA 3 on citrus flower formation. The water-deficit stress floral-induction pathway provides an alternative to low-temperature induction that increases the potential for successful flowering in citrus trees grown in areas experiencing warmer, drier winters due to global climate change.
I Like to Move It: 6D Pose Estimation as an Action Decision Process (2020)

Object pose estimation is an integral part of robot vision and AR. Previous 6D pose retrieval pipelines treat the problem either as a regression task or discretize the pose space to classify. We change this paradigm and reformulate the problem as an action decision process where an initial pose is updated in incremental discrete steps that sequentially move a virtual 3D rendering towards the correct solution. A neural network estimates likely moves from a single RGB image iteratively and determines so an acceptable final pose. In comparison to other approaches that train object-specific pose models, we learn a decision process. This allows for a lightweight architecture while it naturally generalizes to unseen objects. A coherent stop action for process termination enables dynamic reduction of the computation cost if there are insignificant changes in a video sequence. Instead of a static inference time, we thereby automatically increase the runtime depending on the object motion. Robustness and accuracy of our action decision network are evaluated on Laval and YCB video scenes where we significantly improve the state-of-the-art.
OPTIMIZATION OF A RLC SHAPING CIRCUIT FOR NAI(TL) SCINTILLATION DETECTORS (2005)

The problems arising when the output signal from a current pulse detector is further shaped by a RLC circuit are considered. The amplitude dependence of the output signal is derived as a function of the incoming charge. The energy-code transfer function is logarithmic which is a precondition to achieve a wide energy range (more than three decades). The influence of the ratio 00 /τT ( 0T being the period of the RLC circuit&amp;apos;s free oscillations and 0τ being the decay constant of the incoming pulse) on the signal shaping accuracy is investigated.
EP171/#1044 Beside breast/ovarian malignancy: other cancer risk profile in BRCA1 and BRCA2 pathogenic variants (2022)

<h3>Objectives</h3> The clinical significance of genetic testing of BRCA1 and BRCA2 Pathogenic Variants (PV) in women with breast and ovarian cancers is widely recognized. However, there is paucity of evidence to include other cancer types in clinical management guidelines. We aim to study the prevalence of different types of cancers in BRCA 1 AND BRCA2 PV carriers and to associate those with the mutation type. <h3>Methods</h3> This is a cross-sectional study of women carriers of BRCA1 and BRCA2 PV, who attended our designated carrier clinic in a tertiary medical center We compared cancer incidence among the three most prevalence PVs in Israel: 185del, 6174del and 5382insc. <h3>Results</h3> A total of 2,230 women were included. BRCA1 mutation comprised 62.6% of the cohort, BRCA2 36.6% and 0.8% were carriers of both genes. Breast and ovarian/fallopian tube/peritoneal cancer was prevalent in 106 women(4.7%). Most prevalent other cancers were: cutaneous, 1.1%, colon, endometrial and cervical –0.6% each and thyroidal and pancreatic cancers, 0.4% each. The risk of any cancer was higher in 5382insc than 6174del and 185 del; 54.8% vs. 46.3% vs. 36.0% respectively, p&lt;0.001. When excluding breast and ovarian/fallopian tube/peritoneal cancer, the risk of other cancer was similar among the three mutations: 9.3% in 5382insc, 7.2% in 6174del and 7.3% in 185del, (p=0.521). <h3>Conclusions</h3> The results of this large-scale study suggest that pathogenic variants in BRCA1 and BRCA2 were associated with non-negligible risk of other cancers. This risk seems not to be associated with the type of mutation, however larger studies are warranted.
Market Basket Alternatives (1989)

(1989). Market Basket Alternatives. Financial Analysts Journal: Vol. 45, No. 5, pp. 20-29, 61.
TAS2R38 PAV Haplotype Predicts Vegetable Consumption in Community-Dwelling Caucasian Adults at Risk for Cardiovascular Disease (2020)

PAV haplotype predicted lower consumption of vegetables. Variants of taste-related genes appear to play a role in food choices.
Effects of Photodynamic Therapy with Blue Light and Curcumin as Mouth Rinse for Oral Disinfection: A Randomized Controlled Trial (2014)

The PDT group showed significant difference in microbial reduction (p<0.05) compared with both the light and curcumin groups until 2 h post-treatment. The new blue LED device for PDT using curcumin may be used for reduction of salivary microorganisms, leading to overall disinfection of the mouth (e.g., mucosa, tongue, and saliva), but new protocols should be explored.
Gender and Aging (2012)

The growth and development of the musculoskeletal system is a complex process mediated by biological and mechanical factors that produce isolated tissues with differential properties. Together, the tissues of the musculoskeletal system join to produce the body’s form and structure while providing stability and movement capabilities. During maturation, genetics, nutrition, hormones, and mechanical forces drive the tissues of the musculoskeletal system to transform with temporal specicity. These factors individually and collectively produce changes that alter the constituent makeup of the tissue, its morphology, and its biomechanical response. This chapter aims to detail the biomechanical effects of growth and development both on isolated musculoskeletal tissues and on the system as a whole. This review chiey focuses on typical development and its effects on orthopaedic biomechanics. Bone, ligament, tendon, intervertebral disc, cartilage, and skeletal muscle ontogeny are individually discussed as well as their integration into the complete musculoskeletal system. Basic maturation biology and biochemistry are presented to contextualize the changes in tissue morphology, size, and biomechanics. The effects of growth and development are discussed because they pertain to the integrated musculoskeletal systemCONTENTS12.1 Biological Review of Musculoskeletal System Growth and Development ...............330 12.1.1 Bone ......................................................................................................................... 331 12.1.2 Soft Connective Tissue .......................................................................................... 332 12.1.3 Skeletal Muscle .......................................................................................................334