gebhart/patrepeval huggingface dataset:
Mechanisms of alkoxide substitution reactions at the carbon-nitrogen double bond. Stereoelectronic control during nucleophilic substitution (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMechanisms of alkoxide substitution reactions at the carbon-nitrogen double bond. Stereoelectronic control during nucleophilic substitutionJames Elver Johnson, Elizabeth Ann Nalley, Charles Weidig, and Mohammed ArfanCite this: J. Org. Chem. 1981, 46, 18, 3623–3629Publication Date (Print):August 1, 1981Publication History Published online1 May 2002Published inissue 1 August 1981https://doi.org/10.1021/jo00331a008Request reuse permissionsArticle Views218Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (890 KB) Get e-Alertsclose Get e-Alerts
Insulin-like growth factor I is a growth and survival factor in human multiple myeloma cell lines (1996)

Human multiple myeloma (MM) represents a highly aneuploid tumor as shown by cytogenetic studies. This may partly explain the heterogeneity with regard to growth factor requirements demonstrated among MM cells. We have previously reported the expression of insulin-like growth factor I (IGF-I) and IGF-I receptor (IGF-IR) mRNA in some MM cell lines. In this study we investigated the role of IGF-I as a growth and/or survival factor in three MM cell lines: LP-1, EJM, and Karpas 707. We report that all cell lines expressed IGF-I and IGF-IR mRNA and protein. LP-1 and Karpas 707, but not EJM, were stimulated to proliferation in a dose-dependent manner by exogenous IGF-I. An IGF-IR blocking antibody inhibited both the IGF-I-induced and spontaneous growth of LP-1, and Karpas 707, while the EJM cell line was unaffected by the addition of the antibody. In conclusion, our results show that IGF-I can act as a growth factor in human MM, and they suggest that an autocrine IGF-I loop may contribute to the growth and survival in some MM cell lines.
Perceived Depth in Arc 3D Display Can Penetrate into Behind Real Object by Moving Arc 3D Images in Contrast to Unpenetrated Perceived Depth in Stereoscopic Display (2019)

Proceedings of the International Display Workshops Volume 26 (IDW '19),Perceived Depth in Arc 3D Display Can Penetrate into Behind Real Object by Moving Arc 3D Images in Contrast to Unpenetrated Perceived Depth in Stereoscopic Display
Co8FeS8/N,S-Doped Carbons Derived from Fe-Co/S-Bridged Polyphthalocyanine: Efficient Dual-Function Air-Electrode Catalysts for Rechargeable Zn-Air Batteries (2020)

Efficient, durable, nonprecious metal-based catalysts for electrochemical reactions involving oxygen are needed to advance the widespread use of fuel cells and Zn-air batteries. In this work, hybrid materials composed of bimetallic (Co and Fe) sulfide (Co8FeS8) nanoparticles supported on N,S-doped carbon microparticles that can serve as dual-function oxygen electrocatalysts are synthesized. The synthesis of the materials is performed by preparing and then pyrolyzing silica-protected Fe- and Co-modified, S-containing polyphthalocyanine at different temperatures. The materials are named (Fe,Co)SPPc-T-sp, where T denotes the pyrolysis temperature and sp represents the silica protection applied for their synthesis. Among them, the material synthesized at 900 °C, denoted (Fe,Co)SPPc-900-sp, shows superb electrocatalytic activities in an alkaline solution both toward the oxygen reduction reaction (ORR), with a half-wave potential (E1/2) of 0.830 V vs RHE, and toward the oxygen evolution reaction (OER), with a current density of 10 mA cm–2 at an overpotential (η10) of 353 mV. The catalytic activities of this material for both reactions are comparable with those of the respective benchmark, precious-metal-based catalysts, namely, Pt/C (20 wt %) and RuO2, respectively. An alkaline Zn-air battery assembled using (Fe,Co)SPPc-900-sp as an air electrode delivers a high peak power density (158.6 mW cm–2) and outstanding charge–discharge cycling stability (for over 50 h). These catalytic performances are better than those of the corresponding battery containing Pt/C and RuO2 electrocatalysts. This work also offers a facile synthetic strategy for the fabrication of robust, inexpensive dual-function electrocatalysts for Zn-air batteries.
Comparison of U2OS and Huh-7 cells for identifying host factors that affect hepatitis C virus RNA replication (2010)

Host cell factors are critical to all stages of the hepatitis C virus (HCV) life cycle. While many cellular proteins that regulate HCV genome synthesis have been identified, the mechanisms engaged in this process are incompletely understood. To identify novel cellular proteins involved in HCV RNA replication, we screened a library of small interfering RNAs (siRNAs) targeting 299 cellular factors, which principally function in RNA interactions. For the screen, a robust system was established using two cell lines (derived from Huh-7 and U2OS cells) that replicated tricistronic subgenomic replicons (SGRs). We found that the U2OS cell line gave lower levels of intracellular HCV RNA replication compared with Huh-7 cells and was more readily transfected by siRNAs. Consequently, increased gene silencing and greater effects on HCV replication were observed in the U2OS cell line. Thus, U2OS cells provided a suitable and more sensitive alternative to Huh-7 cells for siRNA studies on HCV RNA replication. From the screen, several cellular proteins that enhanced and suppressed HCV RNA replication were identified. One of the genes found to downregulate viral RNA synthesis, ISG15, is expressed in response to alpha interferon and may therefore partly contribute to the clearance of virus from infected individuals. A second gene that inhibited HCV RNA levels was the 5'-3' exoRNase XRN1, which suggested a role for cellular RNA degradation pathways in modulating the abundance of viral genomes. Therefore, this study provides an important framework for future detailed analyses of these and other cellular proteins.
Statistical properties of the RMS delay-spread of mobile radio channels with independent Rayleigh-fading paths (1996)

The statistical properties of the RMS delay-spread for mobile radio channels with independent Rayleigh-fading paths are investigated. We give analytical formulas for the statistical distribution of the local RMS delay-spread for two independent paths (two-delay model). We show that there is a considerable difference between the mean RMS delay-spread and the expected value of the local RMS delay-spread if the number of paths is small; however, this difference vanishes for a large number of paths.
Satellite Fault Diagnosis Using Support Vector Machines Based on a Hybrid Voting Mechanism (2014)

The satellite fault diagnosis has an important role in enhancing the safety, reliability, and availability of the satellite system. However, the problem of enormous parameters and multiple faults makes a challenge to the satellite fault diagnosis. The interactions between parameters and misclassifications from multiple faults will increase the false alarm rate and the false negative rate. On the other hand, for each satellite fault, there is not enough fault data for training. To most of the classification algorithms, it will degrade the performance of model. In this paper, we proposed an improving SVM based on a hybrid voting mechanism (HVM-SVM) to deal with the problem of enormous parameters, multiple faults, and small samples. Many experimental results show that the accuracy of fault diagnosis using HVM-SVM is improved.
Efficient Synthesis of 5-Alkoxy-(3R)-hydroxy-2,3-dihydrospiro[indene-1,4′-piperidines]: A Novel Scaffold for Renin Inhibitors (2009)

We report herein, an efficient synthetic method for the preparation of a 5-alkoxy-(3R)-hydroxy-2,3-dihydrospiro[indene-1,4′-piperidines] scaffold using a regioselective intermolecular ­reaction and a stereoselective reduction as key steps. Compound 2, based on this scaffold, showed moderate in vitro binding affinity for purified human renin.
Immunological profiles associated with distinct parasitemic states in volunteers undergoing malaria challenge in Gabon (2022)

Controlled human malaria infection (CHMI) using cryopreserved non-attenuated Plasmodium falciparum sporozoites (PfSPZ) offers a unique opportunity to investigate naturally acquired immunity (NAI). By analyzing blood samples from 5 malaria-naïve European and 20 African adults with lifelong exposure to malaria, before, 5, and 11 days after direct venous inoculation (DVI) with Sanaria<sup>R</sup> PfSPZ Challenge, we assessed the immunological patterns associated with control of microscopic and submicroscopic parasitemia. All (5/5) European individuals developed parasitemia as defined by thick blood smear (TBS), but 40% (8/20) of the African individuals controlled their parasitemia, and therefore remained thick blood smear-negative (TBS<sup>-</sup> Africans). In the TBS<sup>-</sup> Africans, we observed higher baseline frequencies of CD4<sup>+</sup> T cells producing interferon-gamma (IFNγ) that significantly decreased 5 days after PfSPZ DVI. The TBS<sup>-</sup> Africans, which represent individuals with either very strong and rapid blood-stage immunity or with immunity to liver stages, were stratified into subjects with sub-microscopic parasitemia (TBS<sup>-</sup>PCR<sup>+</sup>) or those with possibly sterilizing immunity (TBS<sup>-</sup>PCR<sup>-</sup>). Higher frequencies of IFNγ<sup>+</sup>TNF<sup>+</sup>CD8<sup>+</sup> γδ T cells at baseline, which later decreased within five days after PfSPZ DVI, were associated with those who remained TBS<sup>-</sup>PCR<sup>-</sup>. These findings suggest that naturally acquired immunity is characterized by different cell types that show varying strengths of malaria parasite control. While the high frequencies of antigen responsive IFNγ<sup>+</sup>CD4<sup>+</sup> T cells in peripheral blood keep the blood-stage parasites to a sub-microscopic level, it is the IFNγ<sup>+</sup>TNF<sup>+</sup>CD8<sup>+</sup> γδ T cells that are associated with either immunity to the liver-stage, or rapid elimination of blood-stage parasites.
Study on efficient analyzing method of operation manuals for runbook automation (2014)

Recently, server consolidation using virtualization is increasing and needs for IT system operation automation are increasing, as well. To shift to automated operation, it is necessary to analyze operation manuals and to standardize procedures by selecting suitable ones. In an environment of server consolidation using virtualization, operation manuals for different systems are gathered for analysis. However, analysis of operation manuals for automation requires high computational complexity. Therefore, analyzing them manually is almost impossible and it is one of the causes that prevent migration from manual to automated operation. In this paper, we propose efficient and comprehensive analysis focused on the characteristic wording of operation manuals and apply natural language processing and data processing algorithms. We apply this approach to a real case of automated operation migration and show that it can accurately and quickly process the entire operation manual.
Family Background, Race, and Labor Market Inequality (2006)

For decades, social scientists have relied on sibling correlations as indicative of the effect of “global family background” on socioeconomic status. This study advances this line of inquiry by drawing on data from the Panel Study of Income Dynamics to analyze racial differences in siblings' labor market and socioeconomic outcomes. We find that African Americans have lower sibling correlations in labor market earnings and family income than whites. Across the life course, African American siblings move toward greater resemblance than whites. These findings suggest that the effect of family background on socioeconomic outcomes is weaker for African Americans than for whites. Volatility in earlier career stages may suppress the effect of family background on labor market outcomes, and this dynamic is especially pronounced for African Americans who lack resources to insulate themselves from volatile events.
Purification and Characterization of Subtilisin DJ-4 Secreted byBacillussp. Strain DJ-4 Screened fromDoen-Jang (2000)

Bacillus sp. strain DJ-4, which produces extracellular proteases, was screened from Doen-Jang, a traditional Korean fermented food. A fibrinolytic enzyme (subtilisin DJ-4) was purified using commercial chromatographic techniques. The relative molecular mass of the isolated protein was 29 kDa by SDS-PAGE and fibrin zymography assay. The enzyme was characterized as a serine protease by an inhibitor assay on the fibrin zymography gel and by an amidolytic assay using a chromogenic substrate. The enzyme was inhibited by PMSF, but not by EDTA or leupeptin. The first 14 amino acids of the N-terminal sequence were identical to that of subtilisin BPN', but the activity of subtilisin DJ-4 was 2.2 and 4.3 times higher than those of subtilisin BPN' and subtilisin Carlsberg, respectively.
Supplementary Tables 1-2 from miR-200 Inhibits Lung Adenocarcinoma Cell Invasion and Metastasis by Targeting <i>Flt1/VEGFR1</i> (2023)

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ChemInform Abstract: MONONITRIDE UND STICKSTOFFREICHERE NITRIDE DER SELTENERDMETALLE 1. MITT. (1973)

Abstract Alle Seltenerdmetalle (mit Ausnahme von Pm) und Ywurden mit Ammoniak und Stickstoff nitridiert.
ClassSheets (2005)

Spreadsheets are widely used in all kinds of business applications. Numerous studies have shown that they contain many errors that sometimes have dramatic impacts. One reason for this situation is the low-level, cell-oriented development process of spreadsheets.We improve this process by introducing and formalizing a higher-level object-oriented model termed ClassSheet. While still following the tabular look-and feel of spreadsheets, ClassSheets allow the developer to express explicitly business object structures within a spreadsheet, which is achieved by integrating concepts from the UML (Unified Modeling Language). A stepwise automatic transformation process generates a spreadsheet application that is consistent with the ClassSheet model. Thus, by deploying the formal underpinning of ClassSheets, a large variety of errors can be prevented that occur in many existing spreadsheet applications today.The presented ClassSheet approach links spreadsheet applications to the object-oriented modeling world and advocates an automatic model-driven development process for spreadsheet applications of high quality.
A p-Type Zinc-Based Metal–Organic Framework (2017)

An original concept for the property tuning of semiconductors is demonstrated by the synthesis of a p-type zinc oxide (ZnO)-like metal-organic framework (MOF), (ZnC<sub>2</sub>O<sub>3</sub>H<sub>2</sub>)<sub>n</sub>, which can be regarded as a possible alternative for ZnO, a natural n-type semiconductor. When small oxygen-rich organic linkers are introduced to the Zn-O system, oxygen vacancies and a deep valence-band maximum, the two obstacles for generating p-type behavior in ZnO, are restrained and raised, respectively. Further studies of this material on the doping and photoluminescence behaviors confirm its resemblance to metal oxides (MOs). This result answers the challenges of generating p-type behavior in an n-type-like system. This concept reveals that a new category of hybrid materials, with an embedded continuous metal-oxygen network, lies between the MOs and MOFs. It provides concrete support for the development of p-type hybrid semiconductors in the near future and, more importantly, the enrichment of tuning possibilities in inorganic semiconductors.
Simulation of Defect Reduction in Block Copolymer Thin Films by Solvent Annealing (2014)

Solvent annealing provides an effective means to control the self-assembly of block copolymer (BCP) thin films. Multiple effects, including swelling, shrinkage, and morphological transitions, act in concert to yield ordered or disordered structures. The current understanding of these processes is limited; by relying on a theoretically informed coarse-grained model of block copolymers, a conceptual framework is presented that permits prediction and rationalization of experimentally observed behaviors. Through proper selection of several process conditions, it is shown that a narrow window of solvent pressures exists over which one can direct a BCP material to form well-ordered, defect-free structures.
A Model of Evaluation: Computational Performance and Usability Benchmarks on Video Stream Context Analysis (2013)

This paper presents a model of evaluation for computing performance and usability benchmarks. The target evaluation is context analysis of video streams. The paper describes the required system components, system architecture and evaluation model, as well as the test cases that can be performed using the designed environment. During the modelling, design, implementation and preliminary tests of the environment, some issues, problems and good-to-know key points were discovered which are explained in this paper. Reference guidance for future test cases is also given. The modelling and experimental results presented in this paper are based on the test environment, and the observations of the cooperation project between Tampere University of Technology Pori Unit and Keio University Shonan Fujisawa Campus.
Field Measurement of Noise and Ground Surface Vibration during Pile Jetting and Grouting (2017)

Noise and vibration are critical issues associated with pile driving operations in an urban environment. Alternative foundations such as drilled shafts and augercast piles alleviate much of the operational noise and vibration. However, the cast-in place installation process may raise concerns in quality control if not adequately monitored. Post grouting the drilled shaft base has been widely used to mobilize a larger portion of the tip resistance prior to construction of the superstructure, thereby controlling the axial displacement during the service. In response to the operational challenges in urban environments, the Florida Department of Transportation and the University of Florida have recently developed a new generation of deep foundation, namely “jetted and grouted precast pile”. The process consists of pressurized water jetting a concrete pile instead of a hammer-driven installation, and subsequent side and tip grouting the pile, which significantly improve skin and tip resistance, respectively, as well as lateral and torsional stiffness. Several studies have been focused on such increase in axial and torsional resistance by grouting techniques. However, there has been little field data available to support quantifiable noise and vibration reduction by jetting and grouting processes. This paper presents field measurements of noise and ground surface vibration during full-scale installation of jetted and grouted piles. Comparison of measured data to recommended noise and vibration limits suggests that jetting and grouting techniques are a viable solution for urban geo-infrastructure development.
Total Syntheses of Multicaulins via Oxidative Photocyclization of Stilbenes (2014)

The Wittig reaction of 3-isopropyl-4-methoxybenzaldehyde and 2,3-dimethylbenzylphosphonium bromide afforded the corresponding stilbene mixture 16. Oxidative photocyclization of stilbene 16 with iodine facilitated the first total synthesis of 7-isopropyl-6-methoxy-1,2-dimethylphenanthrene, multicaulin (1). The O-demethylation of 1 with BBr3 afforded the 7-isopropyl-1,2-dimethylphenanthren-6-ol, O-demethylmulticaulin (2).
Enhanced tunnel magnetoresistance in Fe/Mg4Al-Ox/Fe(001) magnetic tunnel junctions (2022)

Spinel MgAl2O4 and family oxides are emerging barrier materials useful for magnetic tunnel junctions (MTJs). We report large tunnel magnetoresistance (TMR) ratios up to 429% at room temperature (RT) and 1034% at 10 K in a Fe/Mg-rich spinel/Fe(001) MTJ prepared using electron-beam evaporation of Mg4Al-Ox. Resistance oscillations with a MTJ barrier thickness of 0.3 nm were significantly enhanced compared to those of a Fe/MgO/Fe(001) MTJ, resulting in a large TMR oscillation peak-to-valley difference of 125% at RT. The differential conductance (dI/dV) spectra were symmetric with bias polarity, and the spectrum in the parallel magnetization state at low temperature demonstrates significant peaks within broad local minima at |V| = 0.2–0.6 V, indicating improved barrier interfaces by the Mg4Al-Ox barrier. This study demonstrates that TMR ratios in Fe(001)-MTJs can still be improved.
HORNET: High-speed Onion Routing at the Network Layer (2015)

We present HORNET, a system that enables high-speed end-to-end anonymous channels by leveraging next generation network architectures. HORNET is designed as a low-latency onion routing system that operates at the network layer thus enabling a wide range of applications. Our system uses only symmetric cryptography for data forwarding yet requires no per-flow state on intermediate nodes. This design enables HORNET nodes to process anonymous traffic at over 93 Gb/s. HORNET can also scale as required, adding minimal processing overhead per additional anonymous channel. We discuss design and implementation details, as well as a performance and security evaluation.
DESIGN AND ANALYSIS OF INTRA-SUBJECT VARIABILITY IN CROSS-OVER EXPERIMENTS (1996)

Recently, interest has grown in the development of inferential techniques to compare treatment variabilities in the setting of a cross-over experiment. In particular, comparison of treatments with respect to intra-subject variability has greater interest than has inter-subject variability. We begin with a presentation of a general approach for statistical inference within a cross-over design. We discuss three different statistical models where model choice depends on the design and assumptions about carry-over effects. Each model incorporates t-variate random subject effects, where t is the number of treatments. We develop maximum likelihood (ML) and restricted maximum likelihood (REML) approaches to derive parameter estimators and we consider a special case in which closed-form expressions for the variance component estimators are available. Finally, we illustrate the methodologies with the analysis of data from three examples.