gebhart/patrepeval huggingface dataset:
Matrix metalloproteinases in cancer: Prognostic markers and therapeutic targets (2002)

Degradation of extracellular matrix is crucial for malignant tumour growth, invasion, metastasis and angiogenesis. Matrix metalloproteinases (MMPs) are a family of zinc-dependent neutral endopeptidases collectively capable of degrading essentially all matrix components. Elevated levels of distinct MMPs can be detected in tumour tissue or serum of patients with advanced cancer and their role as prognostic indicators in cancer is studied. In addition, therapeutic intervention of tumour growth and invasion based on inhibition of MMP activity is under intensive investigation and several MMP inhibitors are in clinical trials in cancer. In this review, we discuss the current view on the feasibility of MMPs as prognostic markers and as targets for therapeutic intervention in cancer.
Absence of Long-Term Protection in Domestic Pigs Immunized with Attenuated African Swine Fever Virus Isolate OURT88/3 or BeninΔMGF Correlates with Increased Levels of Regulatory T Cells and Interleukin-10 (2020)

Following short immunization protocols, naturally attenuated African swine fever virus (ASFV) isolate OURT88/3 and deletion mutant BeninΔMGF have previously been shown to induce high percentages of protection in domestic pigs against challenge with virulent virus. The results obtained in the present study show that a single intramuscular immunization of domestic pigs with OURT88/3 or BeninΔMGF followed by a challenge with the virulent Benin 97/1 isolate at day 130 postimmunization did not trigger the mechanisms necessary to generate immunological memory able to induce long-term protection against disease. All pigs developed acute forms of acute swine fever (ASF). Gamma interferon-producing cells peaked at day 24 postimmunization, declining thereafter. Surprisingly, the levels of regulatory T cells (Tregs) and interleukin-10 (IL-10) were elevated at the end of the experiment, suggesting that regulatory components of the immune system may inhibit effective protection.<b>IMPORTANCE</b> The duration of immunity for any vaccine candidate is crucial. In the case of African swine fever virus vaccine candidates, this issue has received little attention. Attenuated viruses have proven protective following short immunization protocols in which pigs were challenged a few weeks after the first immunization. Here, the duration of immunity and the immune responses induced over a duration of 130 days were studied during prechallenge and after challenge of pigs immunized with the naturally attenuated isolate OURT88/3 and an attenuated gene-deleted isolate, BeninΔMGF. After a single intramuscular immunization of domestic pigs with the OURT88/3 isolate or BeninΔMGF virus, animals were not protected against challenge with the virulent Benin 97/1 ASFV genotype I isolate at day 130 postimmunization. The levels of regulatory T cells and IL-10 were elevated at the end of the experiment, suggesting that regulatory components of the immune system may inhibit effective protection.
Osmotic Stress Induces Rapid Activation of a Salicylic Acid-Induced Protein Kinase and a Homolog of Protein Kinase ASK1 in Tobacco Cells (2000)

, Olubunmi S. Awotunde, , Daniel F. Klessig, , Osmotic Stress Induces Rapid Activation of a Salicylic Acid-Induced Protein Kinase and a Homolog of Protein Kinase ASK1 in Tobacco Cells, The Plant Cell, Vol. 12, No. 1 (Jan., 2000), pp. 165-178
Propriétés interfaciales d'une protéine membranaire: la(Na+ + K+) adénosine triphosphatase (1978)

Doctorat en Sciences
Dental implant failure rates and associated risk factors. (2005)

Overall, dental implant failure is low and there are no absolute contraindications to implant placement. Conditions that were found to be correlated with an increased risk of failure should be considered during treatment planning and factored into the informed consent process.
Highly selective FSK receiver for a high channel capacity WDM system using a fiber Fabry Perot or a 2-electrode DFB-LD as the optical filter (1993)

The ability of optical fiber to carry large amounts of information can be fully utilized in wavelength division multiplexing (WDM) systems, but significant degradation of transmitted signals occurs when the channel spacing is too small or input power too high. The selectivity of a frequency shift keying (FSK) receiver using a fiber Fabry-Perot filter or a distributed feedback (DFB) laser filter is characterized, and the number of allowable channels, in the authors' system configuration, is determined.
Promoting Photocatalytic Hydrogen Evolution Activity of Graphitic Carbon Nitride with Hole‐Transfer Agents (2020)

Visible light-driven photocatalytic reduction of protons to H<sub>2</sub> is considered a promising way of solar-to-chemical energy conversion. Effective transfer of the photogenerated electrons and holes to the surface of the photocatalyst by minimizing their recombination is essential for achieving a high photocatalytic activity. In general, a sacrificial electron donor is used as a hole scavenger to remove photogenerated holes from the valence band for the continuation of the photocatalytic hydrogen (H<sub>2</sub> ) evolution process. Here, for the first time, the hole-transfer dynamics from Pt-loaded sol-gel-prepared graphitic carbon nitride (Pt-sg-CN) photocatalyst were investigated using different adsorbed hole acceptors along with a sacrificial agent (ascorbic acid). A significant increment (4.84 times) in H<sub>2</sub> production was achieved by employing phenothiazine (PTZ) as the hole acceptor with continuous H<sub>2</sub> production for 3 days. A detailed charge-transfer dynamic of the photocatalytic process in the presence of the hole acceptors was examined by time-resolved photoluminescence and in situ electron paramagnetic resonance studies.
MEASUREMENT OF PICOSECOND LASER PULSE WIDTHS (1967)

The special symmetry properties of second-harmonic generation at the surface of a GaAs crystal are used in a technique which measures the shape of the fast pulses from a mode-locked Nd-glass laser. The pulses studied were found to have a full width at half power of between 4 and 6 picoseconds. The technique is capable of measuring pulse widths at least as short as 4 × 10−13 sec.
The source of protein in the aqueous humor of the normal monkey eye. (1992)

In vivo aqueous fluorophotometry, morphology, and computational modeling were combined to examine the source of protein and the pathway by which protein enters the aqueous humor of monkeys. A computational model was developed to determine the likelihood of a diffusional route for delivering plasma proteins from ciliary body capillaries via the iris to anterior chamber aqueous humor, bypassing the posterior chamber. Model predictions were compared to aqueous fluorophotometric data obtained from monkeys following a single intravenous injection of fluoresceinated horseradish peroxidase (F-HRP, 250 mg/kg body mass). Model predictions of the magnitude and time course of anterior chamber F-HRP concentration agree with the fluorophotometric measurements. For example, of anterior chamber F-HRP concentration as a percentage of initial plasma F-HRP concentration at 90 min and 180 min post-injection was predicted to be 0.02% and 0.05%, respectively, and was measured to be 0.01-0.03% and 0.03-0.06%, respectively. In addition, model predictions in the case of a constant plasma protein level also are consistent with experimental data. The steady-state anterior chamber total protein concentration as a percentage of plasma protein concentration was predicted to be 0.2% and was assayed to be 0.05-0.2%. As in our previous study of the normal rabbit eye, morphologic and tracer localization evidence combined with the good agreement between model predictions and experimental data lead to the conclusion that a significant amount of the plasma protein normally present in monkey aqueous humor originates in ciliary body capillaries and diffuses anteriorly through the iris and into the anterior chamber.
A Study on the Healthy Housing Quality of Multi-family Attached House According to Dwelling Unit Age (2014)

The purpose of this study is to understand the healthy housing quality of four different multi-family attached house complexes that the constructions were finished at different years. In order to evaluate their healthy housing quality, the evaluation indicators of healthy housing, that have already existed, were used and the four complexes with different dwelling unit ages, located in Busan of Korea, were evaluated. For this, this study carry out residents’ evaluations of healthy housing quality through surveys on their satisfaction, and the study mainly identified characteristic according to dwelling unit age. According to the study, the health housing quality of multi-family attached house, of which the dwelling unit age is 10, begins to decrease in terms of managerial aspect. The healthy housing quality of social and managerial aspects is important for dwellers. The evaluation results can then be utilized to develop guidelines to manage and maintain healthy housing environments for apartments.
United States Department of Agriculture–Agricultural Research Service research on natural products for pest management (2003)

Recent research of the Agricultural Research Service of USDA on the use of natural products to manage pests is summarized. Studies of the use of both phytochemicals and diatomaceous earth to manage insect pests are discussed. Chemically characterized compounds, such as a saponin from pepper (Capsicum frutescens L), benzaldehyde, chitosan and 2-deoxy-D-glucose are being studied as natural fungicides. Resin glycosides for pathogen resistance in sweet potato and residues of semi-tropical leguminous plants for nematode control are also under investigation. Bioassay-guided isolation of compounds with potential use as herbicides or herbicide leads is underway at several locations. New natural phytotoxin molecular target sites (asparagine synthetase and fructose-1,6-bisphosphate aldolase) have been discovered. Weed control in sweet potato and rice by allelopathy is under investigation. Molecular approaches to enhance allelopathy in sorghum are also being undertaken. The genes for polyketide synthases involved in production of pesticidal polyketide compounds in fungi are found to provide clues for pesticide discovery. Gene expression profiles in response to fungicides and herbicides are being generated as tools to understand more fully the mode of action and to rapidly determine the molecular target site of new, natural fungicides and herbicides.
Modeling of end-of-range (EOR) defects for indium channel engineering (2002)

A physical model of end-of-range (EOR) defects for indium channel engineering is presented. The model is compared to experimental results. High dose implant damage induces the indium segregation to EOR defects. This segregation is correlated to the deactivation of indium in the vicinity of the S/D junction. This model successfully predicts these behaviors that are essential for indium channel engineering.
Checklist for GCP compliance investigation (Medical institution) (2005)

Abstract This checklist is an English translation of the Good Clinical Practice (GCP) compliance checklist prepared by the Japanese agency for on‐site inspections of medical institutions. Please note that the checklist was translated by the authors and has not received official review by any Japanese agency including the Organization for Pharmaceutical Safety and Research (OPSR). This checklist is an addendum to a previously published article on the evaluation of overseas GCP inspections by the Japanese Regulatory Agency [1]. Copyright © 2005 John Wiley &amp; Sons, Ltd.
Properly Oriented Heparin−Decasaccharide-Induced Dimers Are the Biologically Active Form of Basic Fibroblast Growth Factor, (1997)

Interaction of basic fibroblast growth factor (FGF-2) with heparin or heparan sulfate proteoglycans (HSPGs) is required for receptor activation and initiation of biological responses. To gain insight into the mechanism of activation of the FGF receptor by FGF-2 and heparin, we have used NMR, dynamic light scattering, and HSPG-deficient cells and cell-free systems. The first 28 N-terminal residues in FGF-2 were found to be highly mobile and flexible, consistent with the disorder found in both the NMR and X-ray structures. The structure of an FGF-2-heparin-decasaccharide complex that binds to and activates the FGF receptor was compared to a heparin-tetrasaccharide-induced complex that does not promote an interaction with the receptor. The major change observed upon the addition of the tetrasaccharide to FGF-2 was an increase in the correlation time consistent with the formation of an FGF-2 dimer. The NMR line widths of FGF-2 in the presence of the decasaccharide are severely broadened relative to the tetrasaccharide, consistent with dynamic light scattering results which indicate FGF-2 is a tetramer. The interaction of these heparin species with FGF-2 does not induce a significant conformational change in the overall structure of FGF-2, but small chemical shift changes are observed in both heparin and receptor binding sites. A trans-oriented symmetric dimer of FGF-2 is formed in the presence of the tetrasaccharide whereas two cis-oriented dimers in a symmetric tetramer are formed in the presence of the decasaccharide. This suggests that the cis-oriented FGF-2 dimer is the minimal biologically active structural unit of FGF-2. These data allow us to propose a novel mechanism to explain the functional interaction of FGF-2 with heparin and its transmembrane receptor.
PCC: Re-architecting Congestion Control for Consistent High Performance (2014)

TCP and its variants have suffered from surprisingly poor performance for decades. We argue the TCP family has little hope to achieve consistent high performance due to a fundamental architectural deficiency: hardwiring packet-level events to control responses without understanding the real performance result of its actions. We propose Performance-oriented Congestion Control (PCC), a new congestion control architecture in which each sender continuously observes the connection between its actions and empirically experienced performance, enabling it to consistently adopt actions that result in high performance. We prove that PCC converges to a stable and fair equilibrium. Across many real-world and challenging environments, PCC shows consistent and often 10x performance improvement, with better fairness and stability than TCP. PCC requires no router hardware support or new packet format.
Dynamics of Gene Introgression in the African Malaria Vector Anopheles gambiae (2006)

Anopheles gambiae is a major malaria vector in Africa and a popular model species for a variety of ecological, evolutionary, and genetic studies on vector control. Genetic manipulation of mosquito vectorial capacity is a promising new weapon for the control of malaria. However, the release of exotic transgenic mosquitoes will bring in novel alleles in addition to the parasite-inhibiting genes, which may have unknown effects on the local population. Therefore, it is necessary to develop methodologies that can be used to evaluate the spread rate of introduced genes in A. gambiae. In this study, the effects and dynamics of genetic introgression between two geographically distinct A. gambiae populations from western Kenya (Mbita) and eastern Tanzania (Ifakara) were investigated with amplified fragment length polymorphisms (AFLPs) and microsatellite markers. Microsatellites and polymorphic cDNA markers revealed a large genetic differentiation between the two populations (average F(ST) = 0.093, P < 0.001). When the two strains were crossed in random mating between the two populations, significant differences in the rate of genetic introgression were found in the mixed populations. Allele frequencies of 18 AFLP markers (64.3%) for Mbita and of 26 markers (92.9%) for Ifakara varied significantly from F5 to F20. This study provides basic information on how a mosquito release program would alter the genetic makeup of natural populations, which is critical for pilot field testing and ecological risk evaluation of transgenic mosquitoes.
ChemInform Abstract: Alkylidenesilacyclopropanes Derived from Allenes: Applications to the Selective Synthesis of Triols and Homoallylic Alcohols. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Learning Based Joint Cache and Power Allocation in Fog Radio Access Networks (2020)

The growing demand for rich content services and developments of industrial internet of things and vehicle-to-everything communications pose challenging requirements for the next-generation fog radio access networks (F-RANs). Though F-RANs are promising to support these enabling technologies by leveraging edge caching and edge computing, delay performance is still straightforward and should be optimized. A latency optimization problem for F-RANs is formulated, and to solve the problem, a deep reinforcement learning (DRL) based joint proactive cache placement and power allocation strategy is proposed in this paper. Furthermore, to enhance the content serving capability at the edge, we rigorously consider that a set of F-RAN nodes cooperatively serve the content request. The user's demand can be adaptively satisfied either through fog access point mode at the network edge or by centralized cloud computing mode at the cloud tier. The key idea of the proposal is to learn the user's demand and make an intelligent decision for caching appropriate content and allocating a significant amount of power resources. Simulation results show the effectiveness and performance gains of the proposal under maintaining throughput compared with other baselines.
Environmentally Benign and Self-Extinguishing Multilayer Nanocoating for Protection of Flammable Foam (2020)

Most current flame-retardant nanocoatings for flexible polyurethane foam (PUF) consist of passive barriers, such as clay, graphene oxide, or metal hydroxide. In an effort to develop a polymeric and environmentally benign nanocoating for PUF, positively charged chitosan (CH) and anionic sodium hexametaphosphate (PSP) were deposited using layer-by-layer (LbL) assembly. Only six bilayers of CH/PSP film can withstand flame penetration during exposure to a butane torch (∼1400 °C) for 10 s and stop flame spread on the foam. Additionally, cone calorimetry reveals that the fire growth rate, peak heat release rate, and maximum average rate of heat emission are reduced by 55, 43, and 38%, respectively, compared with uncoated foam. This multilayer thin film quickly dehydrates to form an intumescent charred exoskeleton on the surface of the open-celled structure of polyurethane, inhibiting heat transfer and completely eliminating melt dripping. This entirely polymeric nanocoating provides a safe and effective alternative for reducing the fire hazard of polyurethane foam that is widely used for cushioning and insulation.
Simulation of Casing Treatments ofa Transonic Compressor Stage (2008)

This article presents the study of casing treatments on an axial compressor stage for improving stability and enhancing stall margin. So far, many simulations of casing treatments on single rotor or rotor‐stator configurations were performed. But as the application of casing treatments in engines will be in a multistage compressor, in this study, the axial slots are applied to a typical transonic first stage of a high‐pressure 4.5‐stage compressor including an upstream IGV, rotor, and stator. The unsteady simulations are performed with a three‐dimensional time accurate Favre‐averaged Navier‐stokes flow solver. In order to resolve all important flow mechanisms appearing through the use of casing treatments, a computational multiblock grid consisting of approximately 2.4 million nodes was used for the simulations. The configurations include axial slots in 4 different variations with an axial extension ranging into the blade passage of the IGV. Their shape is semicircular with no inclination in circumferential direction. The simulations proved the effectiveness of casing treatments with an upstream stator. However, the results also showed that the slots have to be carefully positioned relative to the stator location.
Complex Droplets on Chemically Modified Silicon Nanograss (2008)

Dropping in. Chemically modified silicon nanograss combines nanoscale topography with lithographically defined chemical patterns. The material exhibits a high wettability gradient that allows tailoring of complex droplet shapes. The oxidized nanograss is completely wetting, while the polymer-coated nanograss has a contact angle of ca. 170° and is ultrahydrophobic. Novel droplet behavior on these surfaces is studied experimentally. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Model-free learning of wire winding control (2013)

In this paper we introduce a reinforcement learning approach to optimize the wire profile generated by an automated wire winding machine. The wire winder spools wire onto large bobbins, while trying to maintain an even wire profile across the bobbin. Uneven profiles that contain bumps or gaps (i.e. areas with too much or too little wire) lead to snagged or breaking wires when the bobbin is unwound. By setting the turning points of the traversal system which distributes the wire over a spinning bobbin, a controller can influence the amount of wire spooled on the edges of the bobbin. The behavior of the wire, however, is highly non-deterministic and difficult to model with sufficient accuracy, making the application of a model based controller technique very difficult. This fact makes reinforcement learning a promising approach to apply here, as this technique can learn optimal policies relying only on interactions with the plant. We apply a learning algorithm called continuous reinforcement learning automata and empirically demonstrate that this technique can successfully optimize the wire profile, even on rounded bobbins that require continuous adaptation of the turning point.
Fluorenyl andansa-Dimethylsilylbis(fluorenyl) Derivatives of Divalent Ytterbium and Samarium − Synthesis and Structure of the First Mixed-Ligand LnII Classic Sandwich Complex (C13H9)(C5Me5)Yb(DME) (2001)

Novel fluorenyl complexes of divalent ytterbium (C13H9)2Yb(L)n [L = THF, n = 2 (1); L = DME, n = 1 (2)] have been prepared by reaction of YbI2(THF)2 with 2 equiv. of C13H9K as well as by reaction of (C10H8)Yb(THF)2 with fluorene in THF. Oxidation of 1 by tBuN=CHCH=NtBu (DAD) resulted in the formation of (C13H9)2Yb(DAD) (3). The reaction of {YbI(DME)2]2(µ-C10H8)} (4) with fluorene did not give (C13H9)YbI(DME) (5), but the redistribution products YbI2(DME) and 2. The first mixed-ligand sandwich complex of a divalent lanthanide metal (C13H9)(C5Me5)Yb(DME) (6) was prepared in a one-pot reaction of 4 with C5Me5H and C13H9K in DME. ansa-Me2Si(C13H8)2Yb(THF) (7) and ansa-Me2Si(C13H8)2Sm(THF)4 (8) were obtained by treatment of the appropriate LnII iodides with ansa-Me2Si(C13H9)2K2 in THF. The molecular structures of 1 and 6 were determined by single-crystal X-ray diffraction.