gebhart/patrepeval huggingface dataset:
Progesterone receptors in normal mammary gland: receptor modulations in relation to differentiation. (1980)

The biological basis for the observed modulation in cytoplasmic progesterone receptors (PgR) of normal mammary gland occurring during mammary development was investigated. Specifically, the relative roles of hormones vs. differentiation on (a) the decrease in PgR concentration during pregnancy and lactation and (b) the loss of mammary responsiveness to estrogen during lactation were examined. PgR were measured using the synthetic progestin, R5020, as the ligand. The hormones estrogen and progesterone were tested in vivo for their effect of PgR concentration. Mammary gland differentiation was assessed morphologically and by measuring enzymatically active alpha-lactalbumin. These studies show that there is a stepwise decrease in PgR that occurs in two stages. The first decrease is completed by day 12 of pregnancy and the second decrease occurs only after parturition. There appears to be a hormonal basis for the first decrease and it appears to be caused by the negative effect of progesterone on estrogen-mediated increase in PgR. In direct contrast, the absence of PgR during lactation and the mammary tissue insensitivity to estrogenic stimulation of PgR were not related to the hormonal milieu of lactation but were directly related to the secretory state of the mammary gland and lactation per se.
Development of an electronic compact gas meter. Final report, July 1986-December 1987 (1988)

A compact (less than 50 cubic inches), electronic, natural gas flowmeter for residential service was built and tested. Data taken on models of the concept indicate that a microbridge-based meter will provide adequate performance. This report documents the meter model design, the apparatus used for testing, and the tests conducted on the models. An economic analysis conducted by Risk, Inc. is reported in its entirety. The analysis indicates that, to penetrate the marketplace, an electronic gas meter must cost less and offer more features than existing diaphragm meters.
Transcription and Translation of the Herpes Simplex Virus Type 1 Thymidine Kinase Gene after Microinjection into Xenopus laevis Oocytes (1981)

The hybrid plasmid pTK1 consists of the herpes simplex virus type 1 (HSV-1) BamHI p fragment, which contains the thymidine kinase (TK) gene, inserted into the vector pAT 153. When pTK1 DNA was microinjected into nuclei of Xenopus laevis oocytes, functional HSV-1-specific TK was produced, showing that transcription and translation of the gene occurred. Investigation of pTK1-specific RNA by "Southern' blot hybridization revealed that all regions of the hybrid plasmid were transcribed by RNA polymerase II, but sequences present in TK mRNA were most highly represented in stable transcripts.
Design and Synthesis of Collagen-binding Anti-microbial Proteins (2011)

The Herpes simplex virus (HSV) is a virus that commonly infects the skin, and mucous membrane of the mouth, genitalia, and the eye. HSV-1 is the strain that is most commonly associated with corneal infections, and it is the most frequent cause of corneal blindness in North America [1]. Currently no cure is available, and many limitations are characterized by the currently available synthetic antiviral drugs, which suggest the need for other potential drug alternatives and delivery strategies. Anti-microbial peptides are naturally occurring peptides that are potent killers of a broad range of micro-organisms, including bacteria, fungi, and viruses [2]. AMPs are known to be a key component of the innate immune response at the human ocular surface. The human cathelicidin-derived AMP, LL-37, expressed in human corneal epithelial cells provides a wide range of protection against viral pathogens such as HSV-1 [3]. My thesis research addressed the design and recombinant production of hybrid AMP sequences containing LL-37 with the potential ability to form chemical or physical associations with a Collagen scaffold material, such as those used in current artificial cornea constructs to address the need for alternative anti-viral drugs. Three fusion proteins were tested, and compared for feasible design anti-microbial peptide expression and purification in E. coli. It was illustrated that the thioredoxin and SUMO fusion systems are good candidates for successful recombinant production of active designed peptides. The point-mutated LL-37 sequence was successfully expressed and purified using the thioredoxin fusion system. It was demonstrated that this modified LL-37 was effective against HSV-1 infection. The SUMO system was used to express the bio-functional LL-37 containing a collagen-binding sequence. Further work is required to address issues regarding recombinant AMP production, such as increasing enzymatic cleavage efficacy, and minimizing proteolytic degradation or modification.
Destructive-read in embedded DRAM, impact on power consumption (2006)

This paper explores power consumption for destructive-read embedded DRAM. Destructive-read DRAM is based on conventional DRAM design, but with sense amplifiers optimized for lower latency. This speed increase is achieved by not conserving the content of the DRAM cell after a read operation. Random access time to DRAM was reduced from 6 ns to 3 ns in a prototype made by Hwang et al. A write-back buffer was used to conserve data. We have proposed a new scheme for write-back using the usually smaller cache instead of a large additional write-back buffer. Write-back is performed whenever a cache line is replaced. This increases bus and DRAM bank activity compared to a conventional architecture which again increases power consumption. On the other hand computational performance is improved through faster DRAM accesses. Simulation of a CPU, DRAM and a 2 kbytes cache show that the power consumption increased by 3% while the performance increased by 14% for the applications in the SPEC2000 benchmark. With a 16 kbytes cache the power consumption increased by 0.5% while performance increased by 4.5%.
Revision Surgery in Pelvic Discontinuity (2002)

The technical aspect and clinical outcome of seven patients with pelvic discontinuities in acetabular revision surgery after a mean followup of 96 months were analyzed. The surgical treatment consisted of three consecutive steps beginning with mechanical stabilization of the two acetabular columns, followed by bony acetabular reconstruction by filling the osteolytic defect with allograft chips covered with autologous bone to achieve a contained defect after healing of the autograft, and anchorage of the cup using an acetabular reinforcement ring (five with a hook, two without a hook). Complications included a partial ischial nerve lesion, one intraoperative femoral shaft fracture, and one recurrent dislocation. One patient had revision surgery 12 months after the first revision surgery because of aseptic loosening, and in one patient two prominent screws had to be removed. The clinical improvement according to the Harris hip score was 40.1 points on average (preoperative, 33 points; postoperative, 73.1 points). At the final followup all acetabular components were stable and the pelvic discontinuity had healed. Despite the technical feasibility of such revisions and the acceptable clinical results, the complication rate is high. Early diagnosis of acetabular loosening to minimize the osteolytic loss of bone stock is important.
Effect of Methanol Extract of Aegle marmelos Leaves on Mycelial Growth and Sclerotium Formation in Sclerotium rolfsii (1996)

The effect of methanol extract of leaves of a medicinal plant, Aegle marmelos, was seen on the mycelial growth and sclerotium formation in Sclerotium rolfsii. A significant decrease in the mycelial dry weight was observed in the initial incubation periods (7th and 14th day) and a decrease in the number of sclerotia was observed at high concentrations of the extract. At 150 ppm, the highest concentration used in the study, no sclerotia were formed even after 21 days of incubation although, the mycelial weight was comparable with the control. The pH of the culture filtrate was also affected.
220 GHz wideband distributed active power combiner (2015)

This paper presents an active power combiner for UWB applications implemented in a 0.13 μm SiGe BiCMOS technology (f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">t</sub> = 300 GHz, f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">max</sub> = 500 GHz). The circuit is based on distributed architectures: two travelling wave amplifiers sharing the output line are used for the signal combining, whereas a cascade single-stage distributed amplifier ensures high gains for the combining paths. The 3 dB bandwidth of operation is demonstrated from 1 to 170 GHz, while the 6 dB upper frequency exceeds 220 GHz. Good performances in terms of group delay variation are also reported. Over the 3 dB bandwidth the group delay variation is less than 10 ps, and over the 6 dB one it is less than 15 ps. The signal amplification in each path of the combiner is 20 dB from 1 to 170 GHz and it decreases to 15 dB at 220 GHz. Independent bias networks for each combining path enable also selective gain tuning capabilities: a gain tuning range of 20 dB is demonstrated. The system requires a chip area of 0.57 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and 203 mW of DC power. Compared against the state of the art, the presented circuit offers the widest bandwidth as well as the highest combining path gain.
Clinical Tolerance and Catabolism of Plasmin‐Treated γ‐Globulin for Intravenous Application (1975)

Abstract. Plasmin‐treated γ ‐globulin of placental origin was tested in clinical and laboratory studies and found to be suitable for intravenous use both for prophylactic and therapeutic purposes. Plasmin treatment of γ ‐globulin (IgG) results in proteolytic cleavage of 60–70% of the molecules into Fab and Fc fragments whereas 30–40% of the molecules are plasmin resistant. The antibody spectrum of plasmin‐treated γ ‐globulin is similar to that of standard γ ‐globulin. Catabolic properties of the plasmin‐resistant portion of this preparation and of standard γ ‐globulin are identical. Plasmin‐treated γ ‐globulin has no anticomplementary activity and its intravenous administration is well tolerated even by highly sensitive immunodeficient patients.
Na+,K+-ATPase as a Target for Treatment of Tissue Fibrosis (2017)

Myofibroblast activation is a critical process in the pathogenesis of tissue fibrosis accounting for 45% of all deaths. No effective therapies are available for the treatment of fibrotic diseases. We focus our mini-review on recent data showing that cardiotonic steroids (CTS) that are known as potent inhibitors of Na+,K+-ATPase affect myofibroblast differentiation in a cell type-specific manner. In cultured human lung fibroblasts (HLF), epithelial cells, and cancer-associated fibroblasts, CTS blocked myofibroblast differentiation triggered by profibrotic cytokine TGF-β. In contrast, in the absence of TGF-β, CTS augmented myofibroblast differentiation of cultured cardiac fibroblasts. The cell type-specific action of CTS in myofibroblast differentiation is consistent with data obtained in in vivo studies. Thus, infusion of ouabain via osmotic mini-pumps attenuated the development of lung fibrosis in bleomycintreated mice, whereas marinobufagenin stimulated renal and cardiac fibrosis in rats with experimental renal injury. In TGF-β-treated HLF, suppression of myofibroblast differentiation by ouabain is mediated by elevation of the [Na+]i/[K+]i ratio and is accompanied by upregulation of cyclooxygenase COX-2 and downregulation of TGF-β receptor TGFBR2. Augmented expression of COX-2 is abolished by inhibition of Na+/Ca2+ exchanger, suggesting a key role of [Ca2+]i-mediated signaling. What is the relative impact in tissue fibrosis of [Na+]i,[K+]iindependent signaling documented in several types of CTS-treated cells? Do the different conformational transitions of Na+,K+-ATPase α1 subunit in the presence of ouabain and marinobufagenin contribute to their distinct involvement in myofibroblast differentiation? Additional experiments should be done to answer these questions and to develop novel pharmacological approaches for the treatment of fibrosis-related disorders.
Mitosis-Specific Hyperphosphorylation of Epstein-Barr Virus Nuclear Antigen 2 Suppresses Its Function (2004)

The Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA-2) is a key gene expressed in EBV type III latent infection that can transactivate numerous promoters, including those for all the other type III viral latency genes as well as cellular genes responsible for cell proliferation. EBNA-2 is essential for EBV-mediated immortalization of primary B lymphocytes. We now report that EBNA-2, a phosphoprotein, is hyperphosphorylated specifically in mitosis. Evidence that the cyclin-dependent kinase p34(cdc2) may be involved in this hyperphosphorylation includes (i) coimmunoprecipitation of EBNA-2 and p34(cdc2), suggesting physical association; (ii) temporal correlation between hyperphosphorylation of EBNA-2 and an increase in p34(cdc2) kinase activity; and (iii) ability of purified p34(cdc2)/cyclin B1 kinase to phosphorylate EBNA-2 in vitro. Hyperphosphorylation of EBNA-2 appears to suppress its ability to transactivate the latent membrane protein 1 (LMP-1) promoter by about 50%. The association between EBNA-2 and PU.1 is also decreased by about 50% in M-phase-arrested cells, as shown by coimmunoprecipitation from cell lysates, suggesting that hyperphosphorylation of EBNA-2 impairs its affinity for PU.1. Finally, endogenous LMP-1 mRNA levels in M phase are around 55% of those in asynchronously growing cells. These results suggest that regulation of gene expression during type III latency may be regulated in a cell-cycle-related manner.
Simple linguistic processing effect on multi-label emotion classification (2009)

Emotion plays a significant role in human communications in our daily life. With progress in human-machine interface technology, recent research has placed more emphasis on the recognition of emotion reaction. Comparing to some other ideal experimental settings, blog posts online would be respond more to real-world events. And a huge resource of text-based emotion can be found from the World Wide Web nowadays. This paper reports a study to investigate the effectiveness of using SVM (Support Vector Machine) on linguistic features considering emotion keywords and negative words, and classify a collection of blog posts sentences tagged by one or more labels finally. Our results show that individual emotions can be clearly separated by the proposed approach. To the multi-label classification of emotion, it also obtained a higher accuracy rate than the baseline unigram approach using SVM.
Spectroscopy and Kinetics of Photochromic Materials for 3D Optical Memory Devices (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSpectroscopy and Kinetics of Photochromic Materials for 3D Optical Memory DevicesA. S. Dvornikov, J. Malkin, and P. M. RentzepisCite this: J. Phys. Chem. 1994, 98, 27, 6746–6752Publication Date (Print):July 1, 1994Publication History Published online1 May 2002Published inissue 1 July 1994https://pubs.acs.org/doi/10.1021/j100078a016https://doi.org/10.1021/j100078a016research-articleACS PublicationsRequest reuse permissionsArticle Views418Altmetric-Citations56LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Design of Various Shear Connectors for Repair of Corroded Steel Girders with Ultra-High Performance Concrete (2019)

Corrosion accounts for approximately 20% of the structurally deficient bridges in the United States, causing a massive backlog of rehabilitation projects. The current repair procedure for corroded bridge girders is expensive, slow to implement, and necessitates complete closure of the bridge. Through an extensive study supported by the Connecticut Department of Transportation, a novel repair method has been developed to rapidly restore the strength of corroded bridge girder ends with minimal traffic interruption. First, shear connectors in the form of headed studs are welded on the uncorroded web plate above the bearing. Next, formwork is placed and ultra-high-performance concrete (UHPC) is cast down to the bottom flange. This creates an alternate load path around the section loss. Based on the experimental results, it may be concluded that the implementation of the repair reduces the strains on the web plate and strengthens the bridge girder, allowing it to surpass its original capacity. However, the success of the repair centers around the performance of the shear connectors. In addition to headed studs, threaded bars and UHPC dowels in perforated web were evaluated experimentally as alternative shear-transfer mechanisms. This paper presents the repair design objectives and considerations for a realistic girder end utilizing different shear connectors to demonstrate the flexibility and versatility of the repair. The details of the designs are illustrated to facilitate the transition of the research findings to practice.
Non-invasive biomarkers of Fontan-associated liver disease (2021)

In this study, the prevalence of Fontan-associated liver disease (FALD) in the young adult population and clinical variables that may be predictive of fibrosis severity or adverse outcomes were explored. Several lab-based, non-invasive markers of bridging fibrosis in FALD were identified, suggesting that these values may be followed as a prognostic biomarker for FALD progression in the adolescent population.
DEVELOPMENT OF AGNOSTIC MOBILE APPLICATIONS WITH CROSS- PLATFORM CLOUD COMPUTING PLATFORMS (2014)

Smart phones became part and parcel of our life, where mobility provides a freedom of not being bounded by time and space. In addition, number of smartphones produced each year is skyrocketing. However, this also created discrepancies or fragmentation among devices and OSes, which in turn made an exceeding hard for developers to deliver hundreds of similar featured applications with various versions for the market consumption. &#13;\nThis thesis is an attempt to investigate whether cloud based mobile development platforms can mitigate and eventually eliminate fragmentation challenges. During this research, we have selected and analyzed the most popular cloud based development platforms and tested integrated cloud features.&#13;\nThis research showed that cloud based mobile development platforms may able to reduce mobile fragmentation and enable to utilize single codebase to deliver a mobile application for different platforms.
<title>Design And Performance Of A New Emission-Line Coronagraph</title> (1981)

A new emission-line solar coronagraph is described that photographically records coro-nal emission of the Fe XIV (5303 &Aring;) and Fe X (6374 &Aring;) lines, and prominences and the solar disk in H<sub>&alpha;</sub> (6563 &Aring;). The basic optical system consists of a 20-cm aperture, f/11 aspheric singlet objective and four secondary optical systems--one for each image channel--that are sequentially switched into the beam. Interference filters and a specially-designed Lyot birefringent filter isolate spectral bands &asymp; 1 &Aring; at the three wavelengths. The efficiency of this filtering and special constructional features result in an exceptionally small amount of scattered light reaching the film plane. Coronal images can be recorded in skies some 2.5 times brighter than is typical for earlier designs of emission-line corona-graphs. Features of the data obtained so far, including high contrast and high spatial resolution images and the detection of extremely rapid coronal changes, are discussed.
An Improved and Reliable Method for the Induction of Colitis in Rats Using 2,4,6-Trinitrobenzene Sulfonic Acid (2005)

We performed this study to develop a reliable method for inducing colitis in rats using 2,4,6-trinitrobenzene sulfonic acid (TNBS) to reduce the variation in ulcer size. A pair of ring forceps was used to clamp the colon and 0.1 M TNBS in ethanol was injected into the luminal side of the clamped portion. This method resulted in a small coefficient of variation of the ulcer index. A significant linearity was observed by plotting ulcer size against days after ulcer induction in both logarithm scales. These findings show that this technique is simple and reliable and that ulcers heal linearly.
Early predictors of outcome in patients receiving hypervolemic and hypertensive therapy for symptomatic vasospasm after subarachnoid hemorrhage (2000)

The results of this study suggest that outcome in patients with symptomatic vasospasm can be effectively predicted by routinely available information, including GCS score at the time of initiation of hypervolemic and hypertensive therapy. This information can be used for selection and stratification of patients in future treatment studies of patients with symptomatic vasospasm.
Turbidity-Corrected Raman Spectroscopy for Blood Analyte Detection (2009)

A major challenge in quantitative biological Raman spectroscopy, particularly as applied to transcutaneous Raman spectroscopy measurements, is overcoming the deleterious effects of scattering and absorption (turbidity). The Raman spectral information is distorted by multiple scattering and absorption events in the surrounding medium, thereby diminishing the prediction capability of the calibration model. To account for these distortions, we present a novel analytical method, that we call turbidity-corrected Raman spectroscopy (TCRS), which is based on the photon migration approach and employs alternate acquisition of diffuse reflectance and Raman spectra. We demonstrate that, upon application of TCRS, the widely varying Raman spectra observed from a set of tissue phantoms having the same concentration of Raman scatterers but different turbidities has a tendency to collapse onto a single spectral profile. Furthermore, in a prospective study that employs physical tissue models with varying turbidities and randomized concentrations of Raman scatterers and interfering agents, a 20% reduction in prediction error is obtained by applying the turbidity correction procedure to the observed Raman spectra.