gebhart/patrepeval huggingface dataset:
Subacute pyridostigmine exposure increases heart rate recovery and cardiac parasympathetic tone in rats (2017)

Summary Heart rate recovery ( HRR ) describes the rapid deceleration of heart rate after strenuous exercise and is an indicator of parasympathetic tone. A reduction in parasympathetic tone occurs in patients with congestive heart failure, resulting in prolonged HRR . Acetylcholinesterase inhibitors, such as pyridostigmine, can enhance parasympathetic tone by increasing cholinergic input to the heart. The objective of this study was to develop a rodent model of HRR to test the hypothesis that subacute pyridostigmine administration decreases cholinesterase activity and accelerates HRR in rats. Ten days after implantation of radiotelemetry transmitters, male Sprague Dawley rats were randomized to control ( CTL ) or treated ( PYR ; 0.14 mg/mL pyridostigmine in the drinking water, 29 days) groups. Rats were exercised on a treadmill to record HRR , and blood samples were collected on days 0, 7, 14, and 28 of pyridostigmine administration. Total cholinesterase and acetylcholinesterase ( AC hE) activity in plasma was decreased by 32%‐43% and 57%‐80%, respectively, in PYR rats on days 7‐28, while plasma butyrylcholinesterase activity did not significantly change. AC hE activity in red blood cells was markedly reduced by 64%‐66%. HRR recorded 1 minute after exercise was higher in the PYR group on days 7, 14 and 28, and on day 7 when HRR was estimated at 3 and 5 minutes. Autonomic tone was evaluated pharmacologically using sequential administration of muscarinic (atropine) and adrenergic (propranolol) blockers. Parasympathetic tone was increased in PYR rats as compared with the CTL group. These data support the study hypothesis that subacute pyridostigmine administration enhances HRR by increasing cardiac parasympathetic tone.
Growth of epitaxial TiN (111) thin films with low resistivity on Si (111) by crossed-beam pulsed laser deposition (2017)

Titanium nitride (TiN) thin films were grown epitaxially on Si (111) substrates by reactive pulsed laser deposition. Substrate temperatures ranged from 550 to 950 °C while plume kinetic energies ranged from 46 to 154 eV. Quality of the grown films depended strongly on kinetic energy of the films than the growth temperatures. High quality film was grown at 750 °C with a laser plume kinetic energy of ~ 92 eV. Full width at half maximum for a ω-scan around the TiN (111) peak and a φ-scan through the TiN (002) peak were 0.3° and 0.43 °, respectively. The resistivity of the films was increased with increased temperatures and a room temperature resistivity of 3.8 μΩ-cm was obtained.
Karen Zagona, The Syntax of Spanish: 1558 (2003)

We consider the flow of a thin liquid film coating an inclined plane in the presence of a soluble surfactant. A two-dimensional three-equation model is derived using lubrication theory in the rapid diffusion limit and then used to investigate the stability of the fluid height and the surfactant surface and bulk concentrations. We present solutions for an insoluble surfactant system, which are then contrasted with those obtained for a system containing a soluble surfactant; both transient growth and fully nonlinear two-dimensional simulation results are discussed. Our results indicate that the characteristics of the fingering phenomena which accompany the flow are altered by the effects of solubility. In particular, we find that these effects de-stabilise the system further over an intermediate range of surfactant solubility.
New Insights into CO2 Absorption Mechanisms with Amino‐Acid Ionic Liquids (2016)

The last decade saw an explosion of interest in using amine-functionalized materials for CO2 capture and conversion, and it is of great importance to elucidate the relationship between the molecular structure of amine-functionalized materials and their CO2 capacity. In this work, based on a new quantitative analysis method for the CO2 absorption mechanism of amino-acid ionic liquids (ILs) and quantum chemical calculations, we show that the small difference in the local structure of amine groups in ILs could lead to much different CO2 absorption mechanisms, which provides an opportunity for achieving higher CO2 capacity by structure design. This work revealed that the actual CO2 absorption mechanism by amino-acid ILs goes beyond the apparent CO2 /amine stoichiometry; a rigid ring structure around the amine group in ILs creates a unique electrostatic environment that inhibits the deprotonation of carbamic acid and enables actually equimolar CO2 /amine absorption.
Myd88-Dependent In Vivo Maturation of Splenic Dendritic Cells Induced byLeishmania donovaniand Other Leishmania Species (2004)

The usual agent of visceral leishmaniasis in the Old World is Leishmania donovani, which typically produces systemic diseases in humans and mice. L. donovani has developed efficient strategies to infect and persist in macrophages from spleen and liver. Dendritic cells (DC) are sentinels of the immune system. Following recognition of evolutionary conserved microbial products, DC undergo a maturation process and activate antigen-specific naïve T cells. In the present report we provide new insights into how DC detect Leishmania in vivo. We demonstrate that in both C57BL/6 and BALB/c mice, systemic injection of L. donovani induced the migration of splenic DC from marginal zones to T-cell areas. During migration, DC upregulated the expression of major histocompatibility complex II and costimulatory receptors (such as CD40, CD80, and CD86). Leishmania-induced maturation requires live parasites and is not restricted to L. donovani, as L. braziliensis, L. major, and L. mexicana induced a similar process. Using a green fluorescent protein-expressing parasite, we demonstrate that DC undergoing maturation in vivo display no parasite internalization. We also show that L. donovani-induced DC maturation was partially abolished in MyD88-deficient mice. Taken together, our data suggest that Leishmania-induced DC maturation results from direct recognition of Leishmania by DC, and not from DC infection, and that MyD88-dependent receptors are implicated in this process.
Noninvasive Testing for Selection of Patients for Electrophysiological Study (1999)

Background: The implantable cardioverter defibrillator (ICD) has underscored the limitations of our methods of risk assessment. ICDs should be available to patients at high risk for arrhythmic death, but because of the potential for adverse effects and high cost it should be scrupulously avoided in patients whose lives will not be prolonged. Unfortunately, discrimination between these two groups of patients remains a challenge. Recent clinical trial results have not only shown that electrophysiological studies (EPS) in combination with other risk stratifiers identify patients with ischemic heart disease at high risk for arrhythmic death, but they have linked the efficacy of ICD therapy to the results of EPS. However, to perform EPS in all potential candidates for ICD therapy would be a time‐consuming and costly burden to medical services and would expose many patients to the risks and discomfort of an invasive procedure. Noninvasive identification of appropriate candidates is therefore essential to successful application of EPS. Methods: Nonsustained ventricular tachycardia (NSVT) and a reduced left ventricular ejection fraction (EF) was used to select patients for EPS in two important trials, but it is not certain that these are the optimal tests or that the optimal thresholds 1 episode of NSVT 3 beats; EF 0.35 or EF 0.40) were used. A number of studies have addressed the accuracy of clinical factors for predicting the results of EPS and a number of noninvasive tests have been proposed including the signal‐averaged electrocardiogram, heart rate variability, T‐wave alternans, and high spatial resolution (multilead) electrocardiography. In some contexts, combinations of factors provide significant improvements in accuracy. However, the populations studied were often highly selected, which makes comparisons between techniques or prediction of responses in the populations that would require screening difficult. Results from recently completed and ongoing clinical trials should provide important new information. A greater problem is that EPS has not been shown to consistently provide accurate discrimination of patients with nonischemic cardiac disorders. Conclusions: Effective widespread application of ICD therapy will require greater precision of patient selection. Noninvasive tests under investigation demonstrate considerable promise in selecting appropriate candidates for EPS. However, because the most precise methods of risk assessment are likely to be those most closely linked to the mechanisms of fatal arrhythmias, it is important that further development of noninvasive techniques incorporates advances in basic cardiac electrophysiology. A.N.E. 1999;4(4):434–442
A Review on the Life Cycle Assessment of Cellulose: From Properties to the Potential of Making It a Low Carbon Material (2021)

The huge plastic production and plastic pollution are considered important global issues due to environmental aspects. One practical and efficient way to address them is to replace fossil-based plastics with natural-based materials, such as cellulose. The applications of different cellulose products have recently received increasing attention because of their desirable properties, such as biodegradability and sustainability. In this regard, the current study initially reviews cellulose products' properties in three categories, including biopolymers based on the cellulose-derived monomer, cellulose fibers and their derivatives, and nanocellulose. The available life cycle assessments (LCA) for cellulose were comprehensively reviewed and classified at all the stages, including extraction of cellulose in various forms, manufacturing, usage, and disposal. Finally, due to the development of low-carbon materials in recent years and the importance of greenhouse gases (GHG) emissions, the proposed solutions to make cellulose a low carbon material were made. The optimization of the cellulose production process, such as the recovery of excessive solvents and using by-products as inputs for other processes, seem to be the most important step toward making it a low carbon material.
The BB Diabetic Rat: Profound T-Cell Lymphocytopenia (1981)

Approximately 50% of Wistar "BB" rats spontaneously develop overt diabetes mellitus characterized by loss of beta-cells and "insulitis." To define abnormalities of immunoregulation in these rats, we quantitated their major circulating lymphocyte subsets. Independent of the development of diabetes, we found the BB rats to have a markedly increased percentage of circulating B lymphocytes which is secondary to a severe T-cell lymphocytes which is secondary to a severe T-cell lymphocytopenia, with the major circulating T-cell subset reacting with monoclonal antibody W3/25 markedly decreased. This lymphocytopenia is present in every animal studied and contrasted with studies of the nondiabetic Wistar strain from which the "BB" rats were developed.
A brain-like computer for cognitive software applications: the Ersatz Brain project (2005)

We want to design a suitable computer for the efficient execution of the software now being developed that displays human-like cognitive abilities. Examples of these potential software applications include natural language understanding, text processing, conceptually based Internet search, natural human-computer interfaces, cognitively based data mining, sensor fusion, and image understanding. Requirements of the proposed software are primary in shaping our hardware design. The hardware architecture design is based on a few ideas taken from the anatomy of mammalian neo-cortex. In common with other such attempts it is a massively parallel, two-dimensional array of CPUs and their associated memory. However, the design used in this project: (1) uses an approximation to cortical computation called the network of networks which holds that the basic computing unit in the cortex is not a single neuron but small groups of them working together in attractor networks; and (2) assumes connections in cortex are very sparse. The resulting architecture depends largely on local data movement.
Response to Comment on "A Green Algal Apicoplast Ancestor" (2003)

We suggested lateral transfer of split cox2a and cox2b genes from a chlorophyte algal ancestor to an apicomplexan ancestor (1). Waller et al. (2) oppose this interpretation based on a phylogeny implying close affiliation of apicomplexan cox2a and cox2b genes with ciliate cox2 homologues; a 900-bp insertion that separates the corresponding domains in ciliate mitochondrial cox2 genes; and low hydrophobicity values for ciliate mitochondrial COXII and apicomplexan COXIIA and COXIIB subunits. They suggest that mitochondrial cox2 genes were split and transferred to the nuclei of the apicomplexan and chlorophyte ancestors during independent events.
Interleukin 1β inhibits CAR-induced expression of hepatic genes involved in drug and bilirubin clearance (2004)

During the inflammatory response, intrahepatic cholestasis and decreased drug metabolism are frequently observed. At the hepatic level, the orphan nuclear constitutive androstane receptor (CAR) (NR1I3) controls phase I (cytochrome P450 [CYP] 2B and CYP3A), phase II (UGT1A1), and transporter (SLC21A6, MRP2) genes involved in drug metabolism and bilirubin clearance in response to xenobiotics such as phenobarbital or endobiotics such as bilirubin. We investigated the negative regulation of CAR, a glucocorticoid-responsive gene, via proinflammatory cytokine interleukin 1β (IL-1β) and lipopolysaccharides (LPSs) in human hepatocytes. We show that IL-1β decreases CAR expression and decreases phenobarbital- or bilirubin-mediated induction of CYP2B6, CYP2C9, CYP3A4, UGT1A1, GSTA1, GSTA2, and SLC21A6 messenger RNA. This occurs via nuclear factor κB (NF-κB) p65 activation, which interferes with the enhancer function of the distal glucocorticoid response element that we have identified recently in the CAR promoter. We demonstrate that: (1) LPSs, IL-1β, or overexpression of p65RelA inhibit glucocorticoid receptor (GR)-mediated CAR transactivation; (2) these suppressive effects can be blocked both by pyrrolidine dithiocarbamate, an inhibitor of NF-κB activation, or by overexpression of SRIkBα, a NF-κB repressor; and (3) the GR agonist dexamethasone induces histone H4 acetylation at the proximal CAR promoter region, whereas LPSs and IL-1β inhibit this acetylation as assessed via chromatin immunoprecipitation assay. In conclusion, GR/NF-κB interaction affects CAR gene transcription through chromatin remodeling and provide a mechanistic explanation for the long-standing observation that inflammation and sepsis inhibit drug metabolism while inducing intrahepatic cholestasis or hyperbilirubinemia. Supplementary material for this article can be found on the HEPATOLOGY website (http://interscience.wiley.com/jpages/0270-9139/suppmat/index.html). (HEPATOLOGY 2004.)
The Photocycloaddition of 2-Cyclohexenone and Maleic Anhydride to Δ9,10-Octalin (1975)

Abstract The photocycloaddition to Δ9,10-octalin (1) was investigated. Both 2-cyclohexenone and maleic anhydride reacted with 1 to afford the corresponding photocycloadducts, 2 and 3 respectively.
Human mesenchymal stem cells successfully improve skin-substitute wound healing (2005)

These data suggest that hMSCs together with bFGF in a skin defect model accelerate cutaneous wound healing as the hMSCs transdifferentiate into the epithelium.
Polarization multiplexing with solitons (1992)

It is shown both analytically and with numerical simulation, and confirmed experimentally in transmission over distances up to approximately 10000 km, that solitons maintain a high degree of polarization over an ultra-long distance transmission system consisting of birefringent dispersion-shifted fiber segments and erbium amplifiers. Based on that fact, the authors propose a polarization/time division multiplexing technique which should allow the single-wavelength bit-rate capacity of an ultra-long distance soliton transmission system to be doubled with little or no significant increase in bit error rate.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Individualized Tracking of Neurocognitive-State-Dependent Eye-Movement Features Using Mobile Devices (2023)

With current clinical techniques, it is difficult to assess a patient's neurodegenerative disease (e.g., Alzheimer's) state accurately and frequently. The most widely used tests are qualitative or only performed intermittently, motivating the need for quantitative, accurate, and unobtrusive metrics to track disease progression. Clinical studies have shown that saccade latency (an eye movement measure of reaction time) and error rate (the proportion of eye movements in the wrong direction) may be significantly affected by neurocognitive diseases. Nevertheless, how these features change over time as a disease progresses is underdeveloped due to the constrained recording setup. In this work, our goal is to first understand how these features change over time in healthy individuals. To do so, we used a mobile app to frequently and accurately measure these features outside of the clinical environment from 80 healthy participants. We analyzed their longitudinal characteristics and designed an individualized longitudinal model using a Gaussian process. With a system that can measure eye-movement features on a much finer timescale in a broader population, we acquired a better understanding of eye-movement features from healthy individuals and provided research directions in understanding whether eye-movement features can be used to track neurocognitive states.
A novel lignin in poplar trees with a reduced caffeic acid/5‐hydroxyferulic acid O‐methyltransferase activity (1995)

Summary Lignin is a polymeric constituent of the cell wall that needs to be removed during the paper making process. Bi‐specific caffeic acid/5‐hydroxyferulic acid O ‐methyltransferase (COMT) catalyses the O ‐methylation of caffeic acid and 5‐hydroxyferulic acid to ferulic acid and sinapic acid, respectively. These compounds are intermediates in the biosynthesis of the lignin precursors. Therefore, COMTs are potential target enzymes for reducing the amount, or modifying the composition, of lignin in plants. Different antisense and sense constructs have been expressed of a gene encoding a COMT from poplar ( Populus trichocarpa x P. deltoides ) in a P. tremula x P. alba clone under the control of the cauliflower mosaic virus 35S promoter. From all analysed transformants, four lines transformed with an antisense construct had a reduced COMT activity. Two showed a 50% reduction of COMT activity, which altered only slightly the monomeric composition. In the two other transformants, the COMT activity was reduced by 95%. In the latter case, the syringyl/ guaiacyl ratio (S/G) was reduced by sixfold (due to a decrease of S and an increase of G), as analysed by thioacidolysis. A new component of lignin, the 5‐hydroxyguaiacyl residue, was detected among the thioacidolysis products. Moreover, in contrast to the white/yellow colour of wild‐type wood, the xylem of the transgenic lines with a 95% reduction of COMT activity was pale rose. A similar phenotype was observed in brown‐midrib mutants of maize and sorghum, known for their altered lignification. Although the lignin composition was consistently modified, the lignin content of the transgenic poplars was similar to that of the controls.
Supplementary Figures 1-3 from Genetic Ablation of the Amplified-in-Breast Cancer 1 Inhibits Spontaneous Prostate Cancer Progression in Mice (2023)

Supplementary Figures 1-3 from Genetic Ablation of the Amplified-in-Breast Cancer 1 Inhibits Spontaneous Prostate Cancer Progression in Mice
Effect of Increased Nitrogen Application Rates and Environment on Protein, Oil, Fatty Acids, and Minerals in Sesame (&lt;i&gt;Sesamum indicum&lt;/i&gt;) Seed Grown under Mississippi Delta Conditions (2018)

Information on the effect of nitrogen fertilizer rates and environment on sesame seed composition and nutrition is scarce. The objective of this research was to investigate the effects of nitrogen fertilizer application rates on sesame seed yield, protein, oil, fatty acids, and mineral nutrition. A two-year (2014, 2015) field experiment was conducted. Nitrogen fertilizer (urea ammonium nitrate) solution (UAN, 32% N) was applied by side dressing to four sesame varieties (S-34, S-35, S-38, S-39) at rates of 44.7, 67.2, 89.6 and 112.0 kg·ha-1. Rate of 44.7 kg·ha-1 was used as control since this rate is traditionally recommended in the region. Increasing nitrogen application rates resulted in higher protein and oleic acid contents in two varieties in 2014, and in all varieties in 2015. Increased protein and oleic acid were accompanied by lower total oil and linoleic acid. Increased nitrogen application also resulted in higher seed N, S, B, Cu, Fe, and Zn in 2014 in S-34 and S-35, but either a decline or no clear change was observed in seed levels of these nutrients in S-38 and S-39. In 2015, increased nitrogen application resulted in significantly higher seed N in all varieties, and higher S, B, Cu, Fe, and Zn in some varieties. A significant positive correlation was observed between nitrogen application rate and yield, and with seed levels of protein, oleic, acid, N, B, Cu, Fe, and Zn. A significant negative correlation was observed between nitrogen application rate and seed oil and linoleic acid. Thus, increased nitrogen fertilizer application resulted in higher seed protein, oleic acid, and some mineral nutrients, but lower oil and linoleic acid. However, this effect depended on variety and environmental conditions. Because higher protein and oleic acid are desirable traits for sesame seed nutritional value and oil stability, regional breeders should select sesame varieties for efficient fertilizer response.
HDAC6 inhibition enhances 17-AAG–mediated abrogation of hsp90 chaperone function in human leukemia cells (2008)

Histone deacetylase 6 (HDAC6) is a heat shock protein 90 (hsp90) deacetylase. Treatment with pan-HDAC inhibitors or depletion of HDAC6 by siRNA induces hyperacetylation and inhibits ATP binding and chaperone function of hsp90. Treatment with 17-allylamino-demothoxy geldanamycin (17-AAG) also inhibits ATP binding and chaperone function of hsp90, resulting in polyubiquitylation and proteasomal degradation of hsp90 client proteins. In this study, we determined the effect of hsp90 hyperacetylation on the anti-hsp90 and antileukemia activity of 17-AAG. Hyperacetylation of hsp90 increased its binding to 17-AAG, as well as enhanced 17-AAG-mediated attenuation of ATP and the cochaperone p23 binding to hsp90. Notably, treatment with 17-AAG alone also reduced HDAC6 binding to hsp90 and induced hyperacetylation of hsp90. This promoted the proteasomal degradation of HDAC6. Cotreatment with 17-AAG and siRNA to HDAC6 induced more inhibition of hsp90 chaperone function and depletion of BCR-ABL and c-Raf than treatment with either agent alone. In addition, cotreatment with 17-AAG and tubacin augmented the loss of survival of K562 cells and viability of primary acute myeloid leukemia (AML) and chronic myeloid leukemia (CML) samples. These findings demonstrate that HDAC6 is an hsp90 client protein and hyperacetylation of hsp90 augments the anti-hsp90 and antileukemia effects of 17-AAG.