gebhart/patrepeval huggingface dataset:
Acetyl‐Coenzyme‐A Carboxylase of Candida lipolytica (1976)

The level of acetyl‐coenzyme‐A carboxylase activity in Candida lipolytica undergoes large variations depending upon the carbon source on which the yeast is grown. Cells grown on n ‐alkanes or fatty acids exhibit a lower activity level than do cells grown on glucose. Among the n ‐alkanes and fatty acids tested, n ‐heptadecane, n ‐octadecane, oleic acid and linoleic acid reduce the enzyme activity to the lowest levels, which are 16–18% of the activity level in glucose‐grown cells. Immunochemical titrations and Ouchterlony double‐diffusion analysis with specific antibody as well as kinetic studies have indicated that the observed decrease in the level of acetyl‐CoA carboxylase activity is due to a reduction in the cellular content of the enzyme. Furthermore, isotopic leucine incorporation studies with the use of the immunoprecipitation technique have demonstrated that the relative rate of synthesis of the enzyme in oleic‐acid‐grown cells is diminished to 12% of that in glucose‐grown cells. Evidence has also been obtained to support the view that the enzyme in this yeast is not degraded at a rate high enough to contribute to the marked decrease in the cellular content of the enzyme. Thus, it is concluded that the reduction in acetyl‐CoA carboxylase content in fatty‐acid‐grown cells is due to diminished synthesis of the enzyme.
ChemInform Abstract: Zeolites in Organic Syntheses (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Friction mechanism of individual multilayered nanoparticles (2011)

Inorganic nanoparticles of layered [two-dimensional (2D)] compounds with hollow polyhedral structure, known as fullerene-like nanoparticles (IF), were found to have excellent lubricating properties. This behavior can be explained by superposition of three main mechanisms: rolling, sliding, and exfoliation-material transfer (third body). In order to elucidate the tribological mechanism of individual nanoparticles in different regimes, in situ axial nanocompression and shearing forces were applied to individual nanoparticles using a high resolution scanning electron microscope. Gold nanoparticles deposited onto the IF nanoparticles surface served as markers, delineating the motion of individual IF nanoparticle. It can be concluded from these experiments that rolling is an important lubrication mechanism for IF-WS(2) in the relatively low range of normal stress (0.96 ± 0.38 GPa). Sliding is shown to be relevant under slightly higher normal stress, where the spacing between the two mating surfaces does not permit free rolling of the nanoparticles. Exfoliation of the IF nanoparticles becomes the dominant mechanism at the high end of normal stress; above 1.2 GPa and (slow) shear; i.e., boundary lubrication conditions. It is argued that the modus operandi of the nanoparticles depends on their degree of crystallinity (defects); sizes; shape, and their mechanical characteristics. This study suggests that the rolling mechanism, which leads to low friction and wear, could be attained by improving the sphericity of the IF nanoparticle, the dispersion (deagglomeration) of the nanoparticles, and the smoothness of the mating surfaces.
Children's Awareness of the Interaction of Person, Task, and Strategy Variables in Memory and Communication (1988)

Abstract Children's awareness of how different variables (presented separately and in combination) influence memory and communicative performance was investigated. Also assessed was whether this awareness follows the same pattern of development across memory and communication. The variables tested were (a) person (who is doing the remembering or communicating), (b) task (what is to be remembered or communicated), and (c) strategy (how to remember or communicate). Eighteen 4-, 5- and 7-year-old children were asked to judge the difficulty of a memory or communication task based on variations in one variable only, two variables together, and all three variables simultaneously. Children's performance did not differ when their knowledge of the separate effects of the variables was assessed, but when children's knowledge of the interactions of variables was assessed, their performance differed significantly. Five- and 7-year-olds understood the way in which two and three variables interact to affect cognitive performance, but 4-year-olds did not. Children's performance seems to be the same across the cognitive domains of memory and communication.
A concise synthesis of sex pheromone of mediterranean fruit fly, Ceratitis capitata via lithiated carbanion derived from enephosphoramide (2010)

Abstract A novel and versatile synthetic approach to the preparation of ( E )‐non‐6‐en‐1‐ol, a sex pheromone of the Mediterranean fruit fly, Ceratitis capitata , is presented. This pheromone can be viewed as potential active component for lures designed to control and eradication of Mediterranean fruit fly. The described protocol is a six‐step reaction sequence producing the desired compound with 28% overall yield from commercially available and inexpensive starting material and total E stereoselectivity of the double bond present in final structure. The key to the success of the presented strategy is application of lithiated α‐allylphosphoramido carbanions and their reaction with halogenated acetals. © 2010 Wiley Periodicals, Inc. 21:139–147, 2010; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/hc.20588
Supplementary Figure S2 from <i>NPY</i> Methylated ctDNA is a Promising Biomarker for Treatment Response Monitoring in Metastatic Colorectal Cancer (2023)

&lt;p&gt;Kaplan Meier curve for progression free survival.&lt;/p&gt;
Richtigstellung Prof. Dr. U. Leuschner (2013)

Herrn Leuschner bin ich für seine Richtigstellung zum Stellenwert seines Beitrages zur Hepatologie und vor allem zur Einführung der Ursodesoxycholsäure in der Therapie chronischer Leberkrankheiten sehr dankbar. Man sollte sich sowieso eher hüten bei einem solchen Überblick über ein gesamtes Gebiet Namen zu nennen, gerecht werden kann man allen Beteiligten sowieso nicht. Vorsorglich hatte ich am Ende des Artikels in meinen Danksagungen den Satz eingefügt: „Dieser Artikel für die Jubiläumsausgabe der Zeitschrift für Gastroenterologie ist allen denjenigen gewidmet, die zu den Fortschritten der Hepatologie in den letzten 50 Jahren beigetragen haben. Es sollen sich alle angesprochen und keiner ausgeschlossen fühlen.“ Dies gilt für Herrn Leuschner und seine Koautoren in besonderem Maße. In keiner Weise wollte sich der Autor mit der Zitation eines ausländischen anstelle deutscher Autoren schmücken. Das übersehene Abstrakt in deutscher Sprache mit der Erstbeschreibung des Einsatzes der Ursodesoxycholsäure bei chronischen Leberkrankheiten (David R, Kurtz W, Strohm WD, Leuschner U, Z Gastroenterol 1985; 23: 420) gehört sicher zu den bedeutendsten wissenschaftlichen Mitteilungen in der Zeitschrift für Gastroenterologie und sollte im Jubiläumsjahr entsprechend gewürdigt werden, wie im Leserbrief von Herrn Leuschner jetzt geschehen.
Synthesis and biological activity of a series of aza-b3-pseudopeptides related to 26RFa, the endogenous ligand of GPR103. Peptides 2008, Proceedings of the 30th European Peptide Symposium, pp 524-525 (2009)

International audience
Fast pump-down aluminum ultrahigh vacuum system (1992)

An extremely fast pump-down aluminum ultrahigh vacuum system has been developed, with an evacuation time of less than 5 min from atmosphere to pressures in the 10−9 Torr range. Key elements of the system are: (1) a moisture trap (three-stage sintered metal filter) to produce super-dry nitrogen gas, with a water content of about 10 parts per billion, and (2) a cryogenic aluminum alloy panel. A 50 ℓ/s turbomolecular pump is initially used to evacuate the chamber, followed by a 300 ℓ/s turbomolecular pump as the main pump, which immediately operates with normal its full speed. The system can be vented to atmospheric pressure, with the use of super-dry nitrogen gas at a flow rate of 10 ℓ/min, without degradation of the fast pump-down time.
Conference report: The 27th ACM SIGSPATIAL International Conference on Advances in Geographic Information Systems (ACM SIGSPATIAL 2019) (2020)

This report describes the development and finalization of the 27th ACM SIGSPATIAL International Conference on Advances in Geographic Information Systems (ACM SIGSPATIAL 2019), held in Chicago, Illinois, USA, November 5-8, 2019. The attendance for the 2019 conference was 397, the second highest in the history of ACM SIGSPATIAL. Historically, what is now the ACM SIGSPATIAL conference started as a series of workshops and symposia in 1993. Its aim was to promote the interdisciplinary discussions among researchers, developers, users, and practitioners and fostering research in all aspects of Geographic Information Systems --- hence the original workshop acronym ACM GIS. The focus was on novel systems based on geospatial data and knowledge. It continued its mission of providing a forum for original research results, addressing conceptual, design, and implementation aspects of geospatial data ranging from applications, user interfaces and visualization, to data storage, query processing, indexing and data mining. The conference is now the premier annual event of the ACM Special Interest Group on Spatial Information (ACM SIGSPATIAL).
Fiber optic sensors for relative humidity monitoring in High Energy Physics applications (2014)

In this contribution we present investigations developed in the last years by our multidisciplinary research group concerning the use of fiber grating based sensors for relative humidity monitoring in the Compact Muon Solenoid (CMS) experiment at CERN, in Geneva. In particular our research, firstly focused on the development of polyimide coated Fiber Bragg Grating sensors, has been recently extended to Long Period Grating sensors, coated with a finely tuned titanium dioxide (TiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ) thin layer (~100 nm thick). Experimental tests in [0-75] %RH range at different temperatures were carried out to assess the sensors' performances in conditions required in experiments running at CERN. Progressive irradiation campaigns with γ- ionizing radiations were also performed. Obtained results demonstrate the strong potentialities of the proposed technologies in light of their future exploitation as robust and valid alternative to currently used commercial hygrometers in High Energy Physics (HEP) applications.
Structure-taste correlations for flavans and flavanones conformationally equivalent to phyllodulcin (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure-taste correlations for flavans and flavanones conformationally equivalent to phyllodulcinWilliam E. Dick Jr.Cite this: J. Agric. Food Chem. 1981, 29, 2, 305–312Publication Date (Print):March 1, 1981Publication History Published online1 May 2002Published inissue 1 March 1981https://pubs.acs.org/doi/10.1021/jf00104a022https://doi.org/10.1021/jf00104a022research-articleACS PublicationsRequest reuse permissionsArticle Views243Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Dynamic Analysis of the Expression of the TGFβ/SMAD2 Pathway and CCN2/CTGF during Early Steps of Tooth Development (2007)

CCN2 and the TGFbeta/SMAD2/3 signaling pathway are active in signaling centers of tooth development where proliferation is dynamic, but these mechanisms may act independently.
Energetics of complex aluminosilicates (1987)

Systematic trends seen in the thermodynamics of aluminosilicate crystals and glasses at high temperature may be applicable to the complex aluminosilicates encountered as porus media. Specific features of the energetics of charge‐coupled subsitutions (e.g. Si4+→Al3+Na+), of Al,Si order‐disorder, and of the many metastable states shown by crystalline and amorphous SiO2 are discussed.
Melt shear viscosity of PP/Al(OH)3/Mg(OH)2 flame retardant composites at high extrusion rates (2010)

Abstract The melt apparent shear viscosity (η a ) of polypropylene (PP) composites filled with aluminum hydroxide [Al(OH) 3 ] and magnesium hydroxide [Mg(OH) 2 ] was measured by means of a capillary rheometer under experimental conditions of temperature ranging from 180 to 200°C and apparent shear rate varying from 10 to 2 × 10 3 s −1 , to identify the effects of the filler particle content and size on the melt viscosity. The results showed that the melt shear flow of the composites obeyed the power law and presented pseudoplastic behavior. The dependence of η a on temperature was consistent with the Arrhenius equation. The sensitivity of η a for the composite melts to temperature was greater than that of the unfilled PP, and weakened with increasing apparent shear rate. The η a increased linearly with an increase of the weigh fraction of the flame retardant, especially in the low apparent shear rate region. The η a of the composites decreased slightly with an increase of particle size of flame retardant. Moreover, the variation for the η a with particle size of flame retardant was much less than with apparent shear rate under these test conditions. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Deformable MEMS grating for wide tunability and high operating speed (2006)

In optical MEMS, the family of diffractive MEMS is interesting for a wide range of applications, such as displays, scanners or switching elements. Their advantages are compactness, potentially high actuation speed and the ability to deflect light at large angles. A deformable diffraction MEMS grating is presented. Electrostatic actuation has experimentally proven a periodicity tuning of 2.5%. The device first resonant mode is expected to be at 28.5 kHz. The present device has been designed as a tuning element in an external cavity mid-infrared quantum-cascade laser.
Predicting natural language descriptions of mono-molecular odorants (2018)

There has been recent progress in predicting whether common verbal descriptors such as "fishy", "floral" or "fruity" apply to the smell of odorous molecules. However, accurate predictions have been achieved only for a small number of descriptors. Here, we show that applying natural-language semantic representations on a small set of general olfactory perceptual descriptors allows for the accurate inference of perceptual ratings for mono-molecular odorants over a large and potentially arbitrary set of descriptors. This is noteworthy given that the prevailing view is that humans' capacity to identify or characterize odors by name is poor. We successfully apply our semantics-based approach to predict perceptual ratings with an accuracy higher than 0.5 for up to 70 olfactory perceptual descriptors, a ten-fold increase in the number of descriptors from previous attempts. These results imply that the semantic distance between descriptors defines the equivalent of an odorwheel.
Tuning the dynamic exchange interaction in ferromagnet/semiconductor heterostructures (2015)

We investigate the impact of tunnel barrier thickness on electron spin dynamics in Fe/MgO/GaAs heterostructures using spin-resolved optical pump-probe spectroscopy. Comparison of the Larmor frequency between thick and thin MgO barriers reveals a four-fold variation in exchange coupling strength, and investigation of the inhomogeneous dephasing time, <i>T<sub>2</sub><sup>*</sup></i>, argues that inhomogeneity in the local effective hyperfine field dominates free-carrier spin relaxation across the entire range of barrier thickness. These results provide additional evidence to support the theory of hyperfine-dominated spin relaxation in GaAs at low temperature and in the presence of an externally applied magnetic field. Further, this work lays the foundation for engineering both the exchange coupling and the free carrier spin dynamics in ferromagnet/semiconductor heterostructures, allowing for the exploration of dissipation and transport in the regime of dynamically-driven spin pumping.
Blocking IL-1 Signaling Rescues Cognition, Attenuates Tau Pathology, and Restores Neuronal β-Catenin Pathway Function in an Alzheimer’s Disease Model (2011)

Inflammation is a key pathological hallmark of Alzheimer's disease (AD), although its impact on disease progression and neurodegeneration remains an area of active investigation. Among numerous inflammatory cytokines associated with AD, IL-1β in particular has been implicated in playing a pathogenic role. In this study, we sought to investigate whether inhibition of IL-1β signaling provides disease-modifying benefits in an AD mouse model and, if so, by what molecular mechanisms. We report that chronic dosing of 3xTg-AD mice with an IL-1R blocking Ab significantly alters brain inflammatory responses, alleviates cognitive deficits, markedly attenuates tau pathology, and partly reduces certain fibrillar and oligomeric forms of amyloid-β. Alterations in inflammatory responses correspond to reduced NF-κB activity. Furthermore, inhibition of IL-1 signaling reduces the activity of several tau kinases in the brain, including cdk5/p25, GSK-3β, and p38-MAPK, and also reduces phosphorylated tau levels. We also detected a reduction in the astrocyte-derived cytokine, S100B, and in the extent of neuronal Wnt/β-catenin signaling in 3xTg-AD brains, and provided in vitro evidence that these changes may, in part, provide a mechanistic link between IL-1 signaling and GSK-3β activation. Taken together, our results suggest that the IL-1 signaling cascade may be involved in one of the key disease mechanisms for AD.
In vivo and in vitro evidence for autocrine DCoH/HNF‐1α transcription of albumin in the human epidermis (2005)

The presence of albumin in the human epidermis has been reported more than a decade ago, but until now, it was assumed that this protein is synthesized in the liver and transported to the avascular skin. To our knowledge, transcription of albumin in the human epidermis was never considered. In this report, we present for the first time evidence for autocrine synthesis of albumin in the human epidermis in keratinocytes in situ and in vitro. Using double immunofluorescence labelling, we identified that albumin colocalized together with its transcription factor PCD/DCoH/HNF-1alpha in suprabasal keratinocytes in human full-thickness skin sections and in keratinocytes cultured in serum-free medium. Moreover, albumin and HNF-1alpha protein expression was confirmed by Western blotting in undifferentiated and differentiated keratinocytes as well as in human epidermal suction blister roof extracts. Reverse-transcriptase polymerase chain reaction analysis from human epidermal keratinocytes and epidermal suction blister roofs revealed the transcription of albumin. Using in vivo fluorescence excitation spectroscopy at the surface of human skin, we confirmed albumin as a major constituent yielding a lambda(max) at 295 nm, which was assigned to the single tryptophan 214 fluorophore in this protein. This in vivo result is in agreement with albumin concentrations of 10(-3) M, underlining the importance of this protein in epidermal homeostasis.
Prediction model in correcting distortion for elevator guide rail base on FEM method (2011)

As the elevator's guidance system, the elevator guide rail is an important component affecting the safety and comfortableness of elevator. Its distortion degree is an important factor to restricting the development of express elevator. FEM software ABAQUS is used to analyze the correcting method for six initial distortion degree rail in this thesis, the plan of dividing into different steps is put foreword, numerical simulation of correcting stroke parameter for every distortion degree is finished, and obtain satisfactory results, then get the T guide rail's correcting stroke prediction model based on the parameter.
Abstract 389: Gestational Inflammation and Perinatal Arterial Ischemic Stroke: A Causal Connection? (2014)

Introduction: Perinatal arterial ischemic strokes affect about 1/3,000 newborn and are the main cause of hemiplegic cerebral palsy. The large cerebral arteries from the anterior system, namely the intra-cranial carotid bifurcation, are the most affected, ischemic stroke being located in its territory in 85% of cases. The classic, but unproven, pathophysiological hypothesis postulated that arterial occlusion was caused by emboli from placental origin. This remains controversial due to the major unbalance of brain infarcts between anterior and posterior distribution, and to the absence of associated extra-cerebral infarcts. A new pathophysiological perspective emerged from the epidemiological association between gestational inflammation and perinatal stroke. Our hypothesis is that materno-foetal inflammation, induced by gestational exposure to pathogens, leads to a site-specific vasculitis affecting the carotid bifurcation and then triggering a focal thrombosis. Material and methods: Dams were injected with saline or lipopolysaccharide (LPS) from Escherichia coli (200 μg/kg/12h) between gestational day (G) 21 and 22. Brains were harvested at G21, G22 and postnatal day 1 (P1). At P1, a prothrombotic stress (transcutaneous photothrombosis) was applied on middle cerebral arteries to compare its susceptibility to thrombosis between LPS-exposed or unexposed pups. Immunohistochemistry and ELISA detected maternal, placental and fetal/neonatal inflammatory markers. Results: Our results showed a maternal, placental and fetal inflammation mediated by IL-1β, TNF-α and MCP-1 as well as an arterial inflammation in relation with the clinical pattern of perinatal arterial ischemic strokes. LPS+photothrombosis pups presented ischemic strokes and motor impairments, which were not detected when photothrombosis was applied without prior treatment with LPS. Conclusion: Preliminary results from our new pre-clinical model support our hypothesis of increased susceptibility of anterior cerebral arteries to gestational inflammation, and open a new vasculitic pathophysiological avenue to understand perinatal stroke.
Histopathologic and Ultrastructural Findings in Human Myocardium After Stereotactic Body Radiation Therapy for Recalcitrant Ventricular Tachycardia (2020)

Here, we report the first series of findings in human tissue in 4 patients after SBRT. Histopathologic features were consistent across all 4 patients and were indicative of cell injury, death, and to a lesser extent, fibrosis. Electron microscopy demonstrated features consistent with acute injury. These specimens provide radiobiological mechanisms of acute cellular injury during SBRT for VT, which may have an antiarrhythmic effect before the onset of fibrosis.