gebhart/patrepeval huggingface dataset:
Immunological Tolerance: Therapeutic Induction (2009)

Abstract When the natural mechanisms of immune tolerance breakdown, autoimmune or allergic disease can result. There is considerable experimental evidence that the ultimate response to antigen, full immunity or tolerance, is dependent on the activation status of the antigen presenting dendritic cells, with those in steady state inducing tolerance. Current therapeutic options either deplete immune cell populations, interfere with immune cell trafficking to the tissues or inhibit inflammatory cytokine function or lymphocyte signalling. Although these treatments can be effective for certain diseases, they carry with them significant adverse effects and it is unlikely that they induce true, long‐lived immune tolerance. Cellular therapies using either tolerogenic dendritic cells, or regulatory T cells may be able to achieve this. Alternatively, administration of antigen in tolerogenic form can provide the most specific therapy, with the least risk of adversely affecting normal immune function against infection or neoplasia. Key concepts Peripheral tolerance mechanisms consist of lymphocyte apoptosis, anergy and regulation. Current therapeutic options for the clinic can be effective, but in general are nonspecific and may not provide long‐term tolerance. Dendritic cell (DC) activation status determines the type of immune response. Activated DC provokes immunity whereas steady state DC promotes tolerance. ‘Tolerogenic’ DC can be administered to give protection from rodent models of autoimmune disease, allergy and graft rejection. Administration of antigen in tolerogenic form (without adjuvant) also provides protection from disease models. Transfer of antigen‐specific regulatory T cells can also protect against disease, and can be curative in some models. Translation of cellular therapies (using DC or regulatory T cells) or tolerogenic antigen will require a fuller understanding of the critical autoantigens/epitopes that drive autoimmune pathology.
Modelling risk and risking models: The diffusive boundary between science and policy in volcanic risk management (2014)

This article examines the science–policy interface in volcanic risk assessment. It analyses empirical data from research on Montserrat, where new volcanic risk assessment methodologies were pioneered. We discuss the ways in which these methods contributed towards the ordering of scientific advice in its geographical context, and we provide examples of the complex and overlapping topologies that are assembled in a volcanic eruption. In this case, the science–policy interface can be conceptualised as diffusive: both science and policy contain multiple overlapping networks of actors, objects and ideas that interact with one another through flows of responsibilities, attribution, identity and interpretation. Volcanic risk management involves negotiation of conceptual, relational and physical boundaries, and as a result requires the use of qualitative and quantitative methods across human and physical geography.
Structure‐Activity Relationship Studies of CNS Agents, Part 32[1]: Effect of Structural Modifications in 1‐Arylpiperazine Derivatives on α1‐Adrenoreceptor Affinity (1997)

The alpha(1)-adrenergic and 5-HT1A serotonergic receptor affinities of a series of 1-arylpiperazines are presented. The role of the spacer and the influence of the terminal substituents on the alpha(1)-adrenoreceptor affinity and the 5-HT1A/alpha(1) receptor selectivity are discussed.
A step‐wise expansion of intestinal intraepithelial T lymphocytes in association with microbial colonization is defined by sensitivity to cyclosporin A (1997)

Murine intestinal intraepithelial lymphocytes (IELs) consist of T cells bearing alpha beta-antigen receptor (alpha beta-IELs) and those bearing gamma delta-IELs). Although gamma delta-IELs outnumber alpha beta-IELs in germ-free (GF) mice, oral inoculation of fecal suspension from conventional (CV) mice into GF mice induced the increase in number of alpha beta-IELs, leaving the number of gamma delta-IELs unchanged, and the number of alpha beta-IELs reached the level of CV mice by 3 weeks after conventionalization. Expansion of alpha beta-IELs and increase in their CD44+ subset in conventionalized mice were not affected until 2 weeks after beginning of daily injection of cyclosporin A (CsA). However, further expansion of alpha beta-IELs during 2-3 weeks after conventionalization was blocked by injection of CsA. Although the relative constitution of CD4- 8-, CD4+ 8-, CD4- 8 alpha alpha+, CD4- 8 alpha beta+ and CD4+ 8+ subsets among alpha beta-IELs was comparable between control and CsA-treated groups, CsA injection resulted in the decrease in ratio of high-density fraction cells to low density fraction cells in IELs. CsA completely abrogated the expansion of T cells in peripheral lymph nodes stimulated by alloantigens in vivo, and proliferation of IELs from GF mice induced by immobilized anti-alpha beta-T-cell receptor (TCR) monoclonal antibodies (mAb) in vitro was also eliminated by CsA. These results indicate that microbial colonization-induced expansion of alpha beta-IELs is subdivided into two steps: the early phase of expansion takes place via TCR-non-mediated pathway and the late phase of expansion requires TCR-mediated signal transduction.
Simulation of thermal processes of shaft plasma furnace for waste gasification (2021)

Abstract Mathematical modeling of a part of a mine plasma electric furnace for waste gasification is presented. In model calculations, the study of the effect of additional resistive heating as an in-furnace process of drying waste was carried out. In the course of modeling, the electrical resistance of the waste at natural moisture was taken into account. A study was carried out to identify the uniform release of energy inside the waste batch in the drying zone with different connections of the electrodes and the type of current.
A Noise-robust Pulse Wave Estimation from NIR Video using Wiener Estimation Method (2022)

In this paper, we propose a noise-robust pulse wave estimation method from NIR video. Pulse wave estimation in the near-infrared region is expected to be applied to non-contact monitoring in dark areas. Conventional method cannot consider noise when performing estimation, so the accuracy of pulse wave estimation in noisy environment is not very high. This may adversely affect the accuracy of heart rate and other data obtained from pulse waves. Therefore, the objective of this study is to perform pulse wave estimation robust to noise. The Wiener estimation method was used in this study. The Wiener estimation method is a simple linear computation that can consider noise. The proposed method is expected to enable non-contact and accurate estimation of pulse wave from near-infrared video images. Experimental results show that the proposed method estimates the pulse wave more robustly to noise than the conventional method. Furthermore, the heart rate was estimated from the estimated pulse wave and the proposed method was able to obtain a value closer to the ground truth.
SkyVis, an Application of MATLAB in Meteorological Visualization (2003)

We present a work in progress, Sky Vis, which makes it possible to synthesize realistic images of the sky using data from weather parameter data sets. A neural-network-based model is trained to pre ...
Bounds on the aliasing error in multidimensional Shannon sampling (1996)

We present a pair of sharp lower and upper bounds on the 2-norm of the aliasing error in general multiband sampling representations for not necessarily bandlimited multidimensional functions. These bounds improve and generalize previous bounds. They also complement a uniform upper bound due to Higgins (1985).
Esters of 3-Hydroxy-2-Arylindones, a New Class of Acaricide (1973)

Journal Article Esters of 3-Hydroxy-2-Arylindones, a New Class of Acaricide Get access A. A. Sousa, A. A. Sousa Union Carbide Corporation, South Charleston, West Virginia 25303 Search for other works by this author on: Oxford Academic PubMed Google Scholar J. A. Durden, Jr., J. A. Durden, Jr. Union Carbide Corporation, South Charleston, West Virginia 25303 Search for other works by this author on: Oxford Academic PubMed Google Scholar J. F. Stephen J. F. Stephen 2 Union Carbide Corporation, South Charleston, West Virginia 25303 2Present address: Ciba-Geigy Corp., Ardsley, N. Y. 10502. Search for other works by this author on: Oxford Academic PubMed Google Scholar Journal of Economic Entomology, Volume 66, Issue 2, 16 April 1973, Pages 584–586, https://doi.org/10.1093/jee/66.2.584 Published: 16 April 1973 Article history Received: 15 November 1972 Published: 16 April 1973
Wide range single-way-pumping synchronous mirrordelay (2000)

A single-way-pumping scheme for use in wide-bandwidth clocking circuits is proposed to overcome the frequency dependency of the negative-delay values in conventional analogue synchronous mirror delay circuits. The scheme adopts a new dummy-delay compensation technique to achieve an increase in the negative-delay range which becomes especially prominent in high frequency applications.
Long range optimized two‐dimensional proton‐carbon chemical shift correlation. Application in the total assignment of the 1H‐ and 13C‐NMR spectra of 9‐methylphenanthro[4,3‐a]dibenzothiophene (1985)

Abstract The utilization of the long range optimized proton‐carbon chemical shift correlation experiment in the total assignment of the proton and carbon nmr spectra of 9‐methylphenanthro[4,3‐ a ]dibenzothiophene is described. The experiment was employed in concert with conventional proton‐carbon chemical shift correlation, heteronuclear relayed coherence transfer and broad band homonuclearly decoupled proton‐carbon chemical shift correlation experiments. The experiments in combination offer a useful alternative to the 13 C‐ 13 C double quantum coherence experiments, providing significantly better sensitivity and nearly the same capabilities.
Postgres-R(SI): Combining Replica Control with Concurrency Control Based on Snapshot Isolation (2005)

Replicating data over a cluster of workstations is a powerful tool to increase performance, and provide fault-tolerance for demanding database applications. The big challenge in such systems is to combine replica control (keeping the copies consistent) with concurrency control. Most of the research so far has focused on providing the traditional correctness criteria serializability. However, more and more database systems, e.g., Oracle and PostgreSQL, use multi-version concurrency control providing the isolation level snapshot isolation. In this paper, we present Postgres-R(SI), an extension of PostgreSQL offering transparent replication. Our replication tool is designed to work smoothly with PostgreSQL's concurrency control providing snapshot isolation for the entire replicated system. We present a detailed description of the replica control algorithm, and how it is combined with PostgreSQL's concurrency control component. Furthermore, we discuss some challenges we encountered when implementing the protocol. Our performance analysis based on the TPC-W benchmark shows that this approach exhibits excellent performance for real-life applications even if they are update intensive.
Linear viscoelastic studies on a transient network formed by host–guest interaction (2018)

ABSTRACT A host–guest (HG) polymer was prepared through the radical polymerization of acrylamide monomers (AAm) with a small amount of host‐guest linkers, β‐cyclodextrin‐attached AAm (βCD‐AAm) and adamantane‐attached AAm (Ad‐AAm). The linear viscoelastic and swelling measurements indicated that the resulting HG polymer swollen in water was gel‐like, although the HG polymer is conceptually a linear chain having only temporary crosslinkings. NMR measurements indicated that half of the βCD units incorporated in the HG polymer do not form the inclusion complex with Ad. Rheological analysis of the HG polymer revealed that HG interaction retarded the Rouse modes of networks but did not affect the level of the plateau modulus, which was simply described by the entanglements of AAm chains. This result was confirmed with the reference experiment, in which Ad were capped by competitive βCD molecules. Furthermore, the PAAm polymer with only βCD units (no Ad) was found to exhibit gel‐like behavior. This behavior was attributed to the formation of a small amount of rotaxane structure, which act as permanent crosslinkings, based on 2D NMR data. The HG polymer is basically an entanglement network with temporary sticky points due to the HG interaction, and a few permanent branching points. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2018 , 56 , 1109–1117
Decoherence in Josephson Phase Qubits from Junction Resonators (2004)

Although Josephson junction qubits show great promise for quantum computing, the origin of dominant decoherence mechanisms remains unknown. Improving the operation of a Josephson junction based phase qubit has revealed microscopic two-level systems or resonators within the tunnel barrier that cause decoherence. We report spectroscopic data that show a level splitting characteristic of coupling between a two-state qubit and a two-level system. Furthermore, we show Rabi oscillations whose "coherence amplitude" is significantly degraded by the presence of these spurious microwave resonators. The discovery of these resonators impacts the future of Josephson qubits as well as existing Josephson technologies.
Amination with Oximes (2006)

Abstract For Abstract see ChemInform Abstract in Full Text.
Characteristics of lengthening contractions associated with injury to skeletal muscle fibers (1986)

Lengthening (eccentric) contractions result in injury to skeletal muscle fibers. Two hypotheses were tested through lengthening contractions of an in situ muscle preparation: the extent of injury increases with increases in the duration; and the extent of injury increases with increases in the peak force. Mice were anesthetized, and distal tendons of the extensor digitorum longus muscles were attached to a servomotor. Muscles were stimulated at 150 Hz and lengthened 20% of fiber length (Lf). Lengthening contractions were performed at 0.2, 0.5, or 1.0 Lf/s with durations of 0.5-15 min. Peak force during lengthening contractions at 1.0 Lf/s was decreased by inducing fatigue with isometric contractions, stimulating at 70-100 Hz, or 3) lengthening 10% of Lf. Injury was assessed 3 days after lengthening contractions by histological appearance and maximum force (Po) development. Injury increased with duration up to 5 min. After 5 min, fatigue appeared to prevent further injury. Results for 0.2 and 0.5 Lf/s were similar to those for 1.0 Lf/s but with less injury. A high correlation was observed between histological appearance of injury and the decrease in Po. The extent of injury was related to the peak force developed during the lengthening contractions.
A Low Energy Injection-Locked FSK Transceiver With Frequency-to-Amplitude Conversion for Body Sensor Applications (2011)

An energy-efficient 920 MHz FSK transceiver for wireless body sensor network (BSN) applications is implemented in 0.18 μm CMOS technology with 0.7 V supply. A transceiver architecture based on injection-locked frequency divider (ILFD) is proposed for the low energy consumption. In the receiver, the ILFD in the signal path converts the received FSK signal to amplitude-modulated signal which is applied to the next envelope detector. In the transmitter, the ILFD is used as digitally-controlled oscillator (DCO) which directly modulates the FSK signal with digital data. The DCO replaces the frequency synthesizer to eliminate the crystal oscillator (XO), which leads to reduce power consumption and cost. The transceiver can detect whether injection locking occurs or not, and calibrates the frequency drift of DCO over temperature variation thanks to ILFD based architecture. The receiver and transmitter consume 420 μW and 700 μW , respectively, at - 10 dBm output power with a data rate of 5 Mb/s, corresponding to energy consumption of 84 pJ per received bit and 140 pJ per transmitted bit.
ChemInform Abstract: NMR Investigations on Stannabicycloundecanes of the Type RSn(CH2CH2CH2)3N. (1989)

Abstract The 1 H, 13 C, and 119 Sn NMR data for the title compounds (I) are investigated.
Signatures of Immune Evasion in Pediatric Acute Myeloid Leukemia after Allogeneic Hematopoietic Cell Transplantation (2023)

Injury to the anteroinferior labrum (Bankart lesion) and capsuloligamentous complex is the most common injury pattern in young patients following a traumatic anterior shoulder dislocation. Concomitant injuries including glenoid rim (Bony Bankart) and humeral head compression fractures (Hill-Sachs lesion) have been reported to occur in up to 34 and 90% of first-time dislocations, respectively.12 Pectoralis major tendon rupture is a relatively uncommon injury that is not typically associated with events of acute shoulder instability. In over 25 years, only a single case of pectoralis major tendon rupture with simultaneous anterior shoulder dislocation has been reported in the literature.2We present the second reported case of a traumatic anterior shoulder dislocation resulting in a complex anteroinferior labral tear and concomitant pectoralis major tendon rupture in a healthy 28-year-old male following an altercation. Surgical management and the authors’ preferred technique is described.Pectoralis major tendon rupture is a possible accompanying injury in traumatic anterior shoulder dislocations in a younger patient. Physical examination and advanced imaging assessment should evaluate for this uncommon associated injury, which has the potential to influence treatment decisions and discussion between the patient and provider.
Food allergy to pumpkinseed – characterization of allergens (1997)

In recent years, pumpkinseed has become increasingly popular as a foodstuff. Here we report the occurrence of allergic reactions (itching and swelling of oral mucosa, and asthma) to this member of the Cucurbitaceae family. We investigated three patients suffering from symptoms after ingestion of roasted pumpkinseed. All the patients fished for sport and used pressed pumpkinseed flour as bait. Sera were tested by the immunoblot technique for IgE reactivity with proteins of pumpkinseed extract. The immunoblot revealed pumpkinseed allergens of 13, 14, 36, 48, 77, and 87 kDa. Inhibition experiments with recombinant birch profilin were performed: IgE binding to the 14-kDa allergen was completely blocked by preincubation of the sera with recombinant birch profilin. In conclusion, type I allergy to pumpkinseed is rare, and the patients' histories suggest inhalation of pumpkinseed flour during fishing to be the relevant route of sensitization, leading to food allergy to pumpkinseed.
Signal reconstruction under finite-rate measurements: Finite-horizon navigation application (2009)

In this paper, we study finite-length signal reconstruction over a finite-rate noiseless channel. We allow the class of signals to belong to a bounded ellipsoid and derive a universal lower bound on a worst-case reconstruction error. We then compute upper bounds on the error that arise from different coding schemes and under different causality assumptions. We then map our general reconstruction problem into an important control problem in which the plant and controller are local to each other, but are together driven by a remote reference signal that is transmitted through a finite-rate noiseless channel. The problem is to navigate the state of the remote system from a nonzero initial condition to as close to the origin as possible in finite-time. Our analysis enables us to quantify the tradeoff between time horizon and performance accuracy which is not well-studied in the area of control with limited information as most works address infinite-horizon control objectives (eg. stability, disturbance rejection).
ChemInform Abstract: New Synthesis and Cyclopropanation of α‐Phenylselanyl α,β‐Unsaturated Ketones with Non‐Stabilized Phosphorus Ylides. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Nanoscale Measurements of Lithium‐Ion‐Battery Materials using Scanning Probe Techniques (2016)

Abstract State‐of‐the‐art scanning probe microscopy (SPM) methods as applied to energy conversion and storage devices, specifically lithium‐ion batteries, are reviewed with an emphasis on the electroactive elements. The unique ability of SPM‐based methods to provide localized information has proven highly valuable for the in‐depth understanding of the fundamental mechanisms, processes, and degradation of lithium‐ion batteries (LIBs). As such, SPM analysis is poised to play a strong role in the competition for new higher performing LIBs, especially given the unprecedented choice and availability of SPM techniques tailored to provide physical and chemical information at the nanoscale.
Pharmacomodulations around the 4-Oxo-1,4-dihydroquinoline-3-carboxamides, a Class of Potent CB2-Selective Cannabinoid Receptor Ligands:  Consequences in Receptor Affinity and Functionality (2007)

CB2 receptor selective ligands are becoming increasingly attractive drugs due to the potential role of this receptor in several physiopathological processes. Thus, the development of our previously described series of 4-oxo-1,4-dihydroquinoline-3-carboxamides was pursued with the aim to further characterize the structure-affinity and structure-functionality relationships of these derivatives. The influence of the side chain was investigated by synthesizing compounds bearing various carboxamido and keto substituents. On the other hand, the role of the quinoline central scaffold was studied by synthesizing several 6-, 7-, or 8-chloro-4-oxo-1,4-dihydroquinolines, as well as 4-oxo-1,4-dihydronaphthyridine and 4-oxo-1,4-dihydrocinnoline derivatives. The effect of these modifications on the affinity and functionality at the CB2 receptor was studied and allowed for the characterization of new selective CB2 receptor ligands.
Low Oxidation State and Enhanced Magnetic Properties Induced by Raspberry Shaped Nanostructures of Iron Oxide (2015)

Nanostructures with controlled size, morphology, and composition represent a main challenge in materials science because controlling these parameters is fundamental to optimizing the subsequent functional properties. Aggregated nanostructures, combining both individual and collective properties of nanocrystals, offer interesting perspectives to design new magnetic nanomaterials. In that context, original porous raspberry shaped nanostructures consisting of oriented aggregates of ferrite nanocrystals have been synthesized by an one-pot polyol solvothermal method. Synthesis conditions have been optimized to obtain nanostructures featured by similar sizes of about 250 nm and nanocrystal sizes modulated from 5 to 60 nm, leading to porous structures with tunable specific surface area. Structural and magnetic studies of nanostructures as a function of the nanocrystal size evidenced their low oxidation state and enhanced magnetic properties. Indeed, the oriented aggregation of nanocrystals leads to high interface between nanograins reducing significantly their surface oxidation and enhancing their saturation magnetization in comparison to individual nanoparticles of similar sizes. Magnetic moments of each grain are also consequently strongly coupled by dipolar interactions which led to superspin glass effects.