gebhart/patrepeval huggingface dataset:
High Figure of Merit in Gallium-Doped Nanostructured n-Type PbTe-xGeTe with Midgap States (2019)

PbTe-based thermoelectric materials are some of the most promising for converting heat into electricity, but their n-type versions still lag in performance the p-type ones. Here, we introduce midgap states and nanoscale precipitates using Ga-doping and GeTe-alloying to considerably improve the performance of n-type PbTe. The GeTe alloying significantly enlarges the energy band gap of PbTe and subsequent Ga doping introduces special midgap states that lead to an increased density of states (DOS) effective mass and enhanced Seebeck coefficients. Moreover, the nucleated Ga<sub>2</sub>Te<sub>3</sub> nanoscale precipitates and off-center discordant Ge atoms in the PbTe matrix cause intense phonon scattering, strongly reducing the thermal conductivity (∼0.65 W m<sup>-1</sup> K<sup>-1</sup> at 623 K). As a result, a high room-temperature thermoelectric figure of merit ZT ∼ 0.59 and a peak ZT<sub>max</sub> of ∼1.47 at 673 K were obtained for the Pb<sub>0.98</sub>Ga<sub>0.02</sub>Te-5%GeTe. The ZT<sub>avg</sub> value that is most relevant for devices is ∼1.27 from 400 to 773 K, the highest recorded value for n-type PbTe.
Programmable Order Multiple Feedback Band-Pass Active-RC filter for FSK Transceiver (2019)

An integrated programmable order multiple feedback (MFB) band-pass filter (BPF) implemented in 0.14 um CMOS technology is presented. The modular single ended filter has been used in an FSK transceiver, in both receiver (RX) and transmitter (TX). It is implemented by cascading different types of BP filters with different required bandwidth (BW) of RX and TX. A combination of Bessel and Butterworth filters to maximize stop-band rejection, optimize in-band flatness and minimize group delay variation is used. Each stage of the MFB filter draws 0.3mA of current from a 1.8V supply. A simple and efficient approach to trim center frequency which has minimum impact on area and parasitic components has been used. AC gain change of TX due to mismatches, parasitic and process and trimming has been compensated by a simple gain stage while it is budgeted in RX system SNR. The implemented 23.2MHz center frequency filters have been used in the FSK transceiver of a USB power delivery (PD) system, with a BW of 3.46MHz for RX filter and a BW of 1.3MHz for TX filter. The employed low current and small area architecture with its efficient trimming strategy meets the required performance of the FSK transceiver.
Skin Penetration: Hazardous Chemicals At Work (1990)

Part 1 Percutaneous absorption: the skin as a barrier skin exposure at work test methods potentials for classification sources of variation skin denotation selection of chemicals for review preventive approaches. Part 2 Chemicals as percutaneous hazards: inorganic and organometal compounds simple aliphatic compounds halogenated aliphatic compounds aliphatic amines amides nitriles isocyclic hydrocarbons alcohols and related compounds halogenated cyclic compounds isocyclic amines organic nitro-compounds and nitrates other nitrogen compounds heterocyclic oxygen and sulpher compounds organophosphorus compounds organic sulpher compounds.
Essential Role for Vascular Gelatinase Activity in Relaxin-Induced Renal Vasodilation, Hyperfiltration, and Reduced Myogenic Reactivity of Small Arteries (2003)

During pregnancy, relaxin stimulates nitric oxide (NO)-dependent renal vasodilation, hyperfiltration and reduced myogenic reactivity of small renal arteries via the endothelial ETB receptor subtype. Our objective in this study was to elucidate the mechanisms by which relaxin stimulates the endothelial ETB receptor/NO vasodilatory pathway. Using chronically instrumented conscious rats, we demonstrated that a specific peptide inhibitor of the gelatinases MMP-2 and -9, cyclic CTTHWGFTLC (cyclic CTT), but not the control peptide, STTHWGFTLS (STT), completely reversed renal vasodilation and hyperfiltration in relaxin-treated rats. Comparable findings were observed with a structurally different and well-established, general antagonist of MMPs, GM6001. In contrast, phosphoramidon, an inhibitor of endothelin-converting enzyme, did not significantly change the renal vasodilatory response to relaxin administration. When small renal arteries were incubated with either of the general MMP inhibitors, GM6001 or TIMP-2 (tissue inhibitor of MMP), or with the specific gelatinase inhibitor, cyclic CTT, the reduced myogenic reactivity of these blood vessels from relaxin-treated nonpregnant and midterm pregnant rats was totally abolished. Moreover, a neutralizing antibody specific for MMP-2 completely abrogated the reduced myogenic reactivity of small renal arteries from relaxin-treated nonpregnant and midterm pregnant rats. In contrast, phosphoramidon did not significantly affect the reduction in myogenic reactivity. Using gelatin zymography, we showed increased pro and active MMP-2 activity in small renal arteries from relaxin-treated nonpregnant and midterm pregnant rats relative to the control animals. Thus, inhibitors of MMPs in general and of gelatinases in particular reverse the renal vascular changes induced by pregnancy or relaxin administration to nonpregnant rats. Finally, the typical reduction in myogenic reactivity of small renal arteries from relaxin-treated nonpregnant rats was absent in ETB receptor-deficient rats, despite an increase in vascular MMP-2 activity. These results indicate an essential role for vascular gelatinase, which is in series with, and upstream of, the endothelial ETB receptor/NO signaling pathway in the renal vasodilatory response to relaxin and pregnancy.
Efficacy and tolerability of oral iron therapy in inflammatory bowel disease: a prospective, comparative trial (2005)

Oral iron is equally efficacious and well tolerated in inflammatory bowel disease and non-inflammatory bowel disease patients. A tiny minority of inflammatory bowel disease patients relapse in association with use of oral iron therapy.
Purification and characterization of a soluble and a particulate glutamate dehydrogenase from rat brain / Arlene D. Colon, Andreas Plaitakis, Antonis Perakis, Soll Berl, and Donald D. Clarke Department of Neurology, Mount Sinai School of Medicine, New York, and Department of Chemistry, Fordham University, Bronx, New York, U.S.A. (1986)

Glutamate dehydrogenase (GDH) activity was determined in high-speed fractions (1 00,000 g for 60 min) obtained from whole rat brain homogenates after removal of a low-speed pellet (480 g for 10 min). Approximately 60% of the high-speed GDH activity was particulate (associated with membrane) and the remaining was soluble (probably of mitochondrial matrix origin). Most of the particulate GDH activity resisted extraction by several commonly used detergents, high concentration of salt, and sonication; however, it was largely extractable with the cationic detergent cetyltrimethylammonium bromide (CTAB) in hypotonic buffer solution. The two GDH activities were purified using a combination of hydrophobic interaction, ion exchange, and hydroxyapatite chromatography. Throughout these purification steps the two activities showed similar behavior. Kinetic studies indicated similar Km values for the two GDH fractions for the substrates a-ketoglutarate, ammonia, and glutamate; however, there were small but significant differences in Km values for NADH and NADPH. Although the allosteric stimulation by ADP and L-leucine and inhibition by diethylstilbestrol was comparable, the two GDH components differed significantly in their susceptibility to GTP inhibition in the presence of 1 mM ADP, with apparent Ki values of 18.5 and 9.0 ~M GTP for the soluble and particulate fractions, respectively. The Hill plot coefficient, binding constant, and cooperativity index for the GTP inhibition were also significantly different, indicating that the two GDH activities differ in their allosteric sites. In addition, enzyme activities of the two purified proteins exhibited a significant difference in thermal stability when inactivated at 45°C and pH 7.4 in 50 mM phosphate buffer. Key Words: Glutamate dehydrogenase-Particulate- Soluble-GTP-Allosteric regulation. Colon A. D. et al. Purification and characterization of a soluble and a particulate glutamate dehydrogenase from rat brain. J. Neurochem. 46, 1811-1819 (1986)
A Survey on Product Operators in Abstract Interpretation (2013)

The aim of this paper is to provide a general overview of the product operators introduced in the literature as a tool to enhance the analysis accuracy in the Abstract Interpretation framework. In particular we focus on the Cartesian and reduced products, as well as on the reduced cardinal power, an under-used technique whose features deserve to be stressed for their potential impact in practical applications.
Delay performance of high-speed packet switches with low speedup (2003)

The speedup of a switch is the factor by which the switch, and hence the memory used in the switch, runs faster compared to the line rate. In high-speed switches, line rates are already touching the limits at which memory can operate. It is very important for a switch to run at as low a speedup as possible. For an input queued (IQ) switch at speedup 1, 100% throughput can be achieved for any admissible traffic (McKeown, N. et al., 1999; Dai, J. and Prabhakar, B., 2000). This gives finite average delays but does not guarantee control on packet delays. S.T. Chuang et al. (see IEEE J. Selected Areas of Commun., vol.17, no.6, p.1030-9, 1999) show that a combined input output queued (CIOQ) switch can emulate perfectly an output queued (OQ) switch at a speedup of 2 and, thus, control the packet delays. This motivates a study of the possibility of obtaining delay control at speedup less than 2. To guarantee optimal control of delays for a general class of traffic, as shown by Chuang et al., speedup 2 is necessary. Hence, to obtain control of delays at lower speedup, we need to restrict the class of arrival traffic. We study the speedup requirement for a class of admissible traffic, which we denote as (1, nF)-regulated traffic, with parameters n and F. We obtain the necessary speedup for this class of traffic. Further, we present a general class of algorithms working at the necessary speedups and thus providing bounded delays.
The Influence of Particle Size Distribution and Shell Imperfections on the Plasmon Resonance of Au and Ag Nanoshells (2016)

Au and Ag nanoshells are of interest for a wide range of applications. The plasmon resonance of such nanoshells is the property of interest and can be tuned in a broad spectral regime, ranging from the ultraviolet to the mid-infrared. To date, a large number of manuscripts have been published on the optics of such nanoshells. Few of these, however, address the effect of particle size distribution and metal shell imperfections on the plasmon resonance. Both are inherent to the chemical synthesis of metal nanoshells and therefore to a large extent unavoidable. It is of vital importance to understand their effect on the plasmon resonance, since this determines the scope and limitations of the technology and may have a direct impact on the application of such particles. Here, we elucidate the effect of particle size distribution and imperfections in the metal shell on the plasmon resonance of Au and Ag nanoshells. The size of the polystyrene core and the thickness of the Au and Ag shells are systematically varied to study their influence on the plasmon resonance, and the results are compared to values obtained through optical simulations using extended Mie theory and finite element method. Discrepancies between theory and practice are studied in detail and discussed extensively. Quantitative information on the minimum thickness of the metal shell, which is required to realize a satisfactory plasmon resonance of a metal nanoshell, is provided for Au and Ag.
Oncolytic Alphaviruses in Cancer Immunotherapy (2017)

Oncolytic viruses show specific targeting and killing of tumor cells and therefore provide attractive assets for cancer immunotherapy. In parallel to oncolytic viral vectors based on adenoviruses and herpes simplex viruses, oncolytic RNA viruses and particularly alphaviruses have been evaluated as delivery vehicles. Immunization studies in experimental rodent models for various cancers including glioblastoma, hematologic, hepatocellular, colon, cervix, and lung cancer as well as melanoma have been conducted with naturally occurring oncolytic alphavirus strains such as M1 and Sindbis AR339. Moreover, animals were vaccinated with engineered oncolytic replication-deficient and -competent Semliki Forest virus, Sindbis virus and Venezuelan equine encephalitis virus vectors expressing various antigens. Vaccinations elicited strong antibody responses and resulted in tumor growth inhibition, tumor regression and even complete tumor eradication. Vaccination also led to prolonged survival in several animal models. Furthermore, preclinical evaluation demonstrated both prophylactic and therapeutic efficacy of oncolytic alphavirus administration. Clinical trials in humans have mainly been limited to safety studies so far.
1.2 Gbit/s optical fibre transmission experiment over 113.7 km using a 1.528 μm distributed-feedback ridge-waveguide laser (1984)

Optical fibre transmission experiments at 1.2 Gbit/s are reported over distances up to 113.7 km of conventional nondispersion-shifted fibre. The experimental system comprises a DFB laser, a PINFET and a parallel-processing regenerator. System penalties are observed which may be partly attributed to transient wavelength chirping and chromatic dispersion. Experiments using 83 km of dispersion shifted fibre show no penalties.
Nonproteinuric diabetic kidney disease (2020)

Proteinuria has been considered to be the hallmark of diabetic kidney disease and to precede renal function loss. However, it has become clear that a substantial proportion of patients either with type 1 diabetes or type 2 diabetes have renal function loss without proteinuria, known as nonproteinuric diabetic kidney disease. Despite increasing recognition of the prevalence of nonproteinuric diabetic kidney disease, data on this phenotype of diabetic kidney disease is sparse. This review describes ever known clinical and pathological manifestations, renal prognosis, and mortality in patient with nonproteinuric diabetic kidney disease.
Nonthermal Effects of Millimeter Microwaves on Yeast Growth (1978)

Weak microwave irradiation of aqueous yeast cultures was found to affect their growth rate in a frequency-selective manner. Depending on frequency (near 42 GHz), both increases and decreases of the growth rate were observed. The resonance bandwidths are of the order of 0.01 GHz. Simple thermal effects can be excluded. These findings support theoretical predictions of coherent molecular oscillations activating metabolic processes.
Tutorial: abstraction in numerical methods (1988)

We illustrate how the liberal use of high-order procedural abstractions and infinite streams helps us to express some of the vocabulary and methods of numerical analysis. We develop a software toolbox encapsulating the technique of Richardson extrapolation, and we apply these tools to the problems of numerical integration and differentiation. By separating the idea of Richardson extrapolation from its use in particular circumstances we indicate how numerical programs can be written that exhibit the structure of the ideas from which they are formed.
TurKit: Tools for iterative tasks on mechanical turk (2009)

Mechanical Turk (MTurk) is an increasingly popular web service for paying people small rewards to do human computation tasks. Current uses of MTurk typically post independent parallel tasks. I am exploring an alternative iterative paradigm, in which workers build on or evaluate each other's work. Part of my proposal is a toolkit called TurKit which facilitates deployment of iterative tasks on MTurk. I want to explore using this technology as a new form of end-user programming, where end-users are writing ldquoprogramsrdquo that are really instructions executed by humans on MTurk.
Focal adhesion kinase modulates tension signaling to control actin and focal adhesion dynamics (2007)

In response to alphabeta1 integrin signaling, transducers such as focal adhesion kinase (FAK) become activated, relaying to specific machineries and triggering distinct cellular responses. By conditionally ablating Fak in skin epidermis and culturing Fak-null keratinocytes, we show that FAK is dispensable for epidermal adhesion and basement membrane assembly, both of which require alphabeta1 integrins. FAK is also dispensible for proliferation/survival in enriched medium. In contrast, FAK functions downstream of alphabeta1 integrin in regulating cytoskeletal dynamics and orchestrating polarized keratinocyte migration out of epidermal explants. Fak-null keratinocytes display an aberrant actin cytoskeleton, which is tightly associated with robust, peripheral focal adhesions and microtubules. We find that without FAK, Src, p190RhoGAP, and PKL-PIX-PAK, localization and/or activation at focal adhesions are impaired, leading to elevated Rho activity, phosphorylation of myosin light chain kinase, and enhanced tensile stress fibers. We show that, together, these FAK-dependent activities are critical to control the turnover of focal adhesions, which is perturbed in the absence of FAK.
ChemInform Abstract: Single‐Electron Transfer in Deacylation of Ethyl Dinitrobenzoates. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Intervalence transfer in mixed-metal dimers of ruthenium and osmium: relationship between redox asymmetry and the intervalence-transfer absorption band (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIntervalence transfer in mixed-metal dimers of ruthenium and osmium: relationship between redox asymmetry and the intervalence-transfer absorption bandKenneth A. Goldsby and Thomas J. MeyerCite this: Inorg. Chem. 1984, 23, 19, 3002–3010Publication Date (Print):September 1, 1984Publication History Published online1 May 2002Published inissue 1 September 1984https://pubs.acs.org/doi/10.1021/ic00187a021https://doi.org/10.1021/ic00187a021research-articleACS PublicationsRequest reuse permissionsArticle Views438Altmetric-Citations89LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
In situ observation of coarsening in a phase-separated glass (2013)

Using X-Ray micro-tomography, we follow in situ the coarsening of a phase-separated ternary silicate glass in the liquid state. The domains of the minority phase are identified after segmentation of the 3D images, and various geometrical characteristics are measured, including volumes, areas, mean and gaussian curvatures, as a function of time for each domain. The characteristic length scale L follows the linear behavior in time t predicted for the viscous coarsening: L(t)∼t. In addition, three-dimensional geometrical characteristics of phase separation, such as the shape of domains, or the size distribution of domains are reported here for the first time.
ChemInform Abstract: One‐Pot Formation of Allylic Chlorides from Carbonyl Derivatives. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A Comparative Study of ±1 Steganalyzers (2008)

Abstract—We compare the performance of three steganalysis system for detection of ±1 steganography. We examine the relative performance of each system on three commonly used image databases. Experimental results clearly demonstrate that both absolute and relative performance of all three algorithms vary considerably across databases. This sensitivity suggests that considerably more work is needed to develop databases that are more representative of diverse imagery. In addition, we investigate how performance varies based on a variety of training and testing assumptions, specifically (i) that training and testing are performed for a fixed and known embedding rate, (ii) training is performed at one embedding rate, but testing is over a range of embedding rates, (iii) training and testing are performed over a range of embedding rates. As expected, experimental results show that performance under (ii) and (iii) is inferior to (i). The experimental results also suggest that test results for different embedding rates should not be consolidated into a single score, but rather reported separately. Otherwise, good performance at high embedding rates may mask poor performance at low embedding rates. I.
Immobilization and Clustering of Structurally Defined Oligosaccharides for Sugar Chips:  An Improved Method for Surface Plasmon Resonance Analysis of Protein−Carbohydrate Interactions (2006)

Oligosaccharides are increasingly being recognized as important partners in receptor-ligand binding and cellular signaling. Surface plasmon resonance (SPR) is a very powerful tool for the real-time study of the specific interactions between biological molecules. We report here an advanced method for the immobilization of oligosaccharides in clustered structures for SPR and their application to the analysis of heparin-protein interactions. Reductive amination reactions and linker molecules were designed and optimized. Using mono-, tri-, or tetravalent linker compounds, we incorporated synthetic structurally defined disaccharide units of heparin and immobilized them as ligands for SPR. Their binding to an important hemostatic protein, von Willebrand factor (vWf), and its known heparin-binding domain was quantitatively analyzed. These multivalent ligand conjugates exhibited reproducible binding behavior, with consistency of the surface conditions of the SPR chip. This novel technique for oligosaccharide immobilization in SPR studies is accurate, specific, and easily applicable to both synthetic and naturally derived oligosaccharides.
KERNEL-BASED STOCHASTIC COLLOCATION FOR THE RANDOM TWO-PHASE NAVIER-STOKES EQUATIONS (2019)

In this work, we apply stochastic collocation methods with radial kernel basis functions for an uncertainty quantification of the random incompressible two-phase Navier-Stokes equations. Our approach is nonintrusive and we use the existing fluid dynamics solver NaSt3DGPF to solve the incompressible two-phase Navier-Stokes equation for each given realization. We are able to empirically show that the resulting kernel-based stochastic collocation is highly competitive in this setting and even outperforms some other standard methods.