gebhart/patrepeval huggingface dataset:
High‐Volumetric Performance Aligned Nano‐Porous Microwave Exfoliated Graphite Oxide‐based Electrochemical Capacitors (2013)

Ultra-high volumetric performance electrochemical double layer capacitors based on high density aligned nano-porous microwave exfoliated graphite oxide have been studied. Elimination of macro-, meso-, and larger micro-pores from electrodes and controlling the nano-morphology results in very high volumetric capacitance, energy, and power density values.
Reduction of Toxicity by Reversing the Order of Infusion of Docetaxel and Cyclophosphamide (2013)

Nonhematological toxicities are less common in cases receiving rTC in comparison to those receiving TC.
Supplementary Figure 3 from Tolerance of Whole-Genome Doubling Propagates Chromosomal Instability and Accelerates Cancer Genome Evolution (2023)

&lt;p&gt;PDF file 41K, Supplementary Figure 3: A-B) Segregation error type analysis in diploid and tetraploid clones. C) Colony-to-colony variation in chromosome number for HCT-116_MLH clones&lt;/p&gt;
Target cells are sensitized for cytotoxic T‐lymphocyte‐mediated destruction by estradiol and tamoxifen (1994)

The effect of estradiol (E2) and tamoxifen (TX) on cytotoxic T-lymphocyte (CTL)-mediated target-cell lysis was studied. CTL was generated in mixed cultures of rat spleen cells, using female Fischer 344 rat cells as responders and female Wistar rat cells or Nb2 rat lymphoma cells as stimulators. Concanavalin-A-stimulated Wistar lymphoblasts or Nb2 cells were used as targets. CTL harvested on day 5 exerted 16-25% cytotoxicity when used at 1:12-1:50 target:effector cell ratios. Day-6 CTL had no cytotoxic activity. Treatment of target cells with either TX or E2, or both, at 1-microM concentrations for 4 hr prior to cytotoxicity testing raised the target-cell killing to 100%. Highly significant enhancement of cytotoxicity was also observed when the drugs were used at 100-, 10-, or 1-nM concentrations. Treatment of effector cells under similar conditions led to inhibition of cytotoxicity at 1-microM concentration, some enhancement at 100 nM and no effect at 10 and 1 nM. When treated target and effector cells were combined, the amplification of target-cell lysis was similar in magnitude to that seen in tests with treated targets only. Drug treatment of target cells had no influence on their resistance to lysis in hypotonic solutions or on total and spontaneous 51Cr release. The inhibition of DNA and protein synthesis in target cells interfered with both basal cytolysis and drug-induced enhancement. The release of the nuclear label, [3H]-thymidine, from Nb2 targets by CTL, was also enhanced by target treatment with TX. These results illustrate that CTL-mediated cytotoxicity is amplified by physiological concentrations (1 and 10 nM) of E2 and equimolar concentrations of TX.
A Pixel-Wise Varifocal Camera Model for Efficient Forward Projection and Linear Extrinsic Calibration of Underwater Cameras with Flat Housings (2013)

This paper is aimed at presenting a new virtual camera model which can efficiently model refraction through flat housings in underwater photography. The key idea is to employ a pixel-wise virtual focal length concept to encode the refractive projection inside the flat housing. The radially-symmetric structure of the varifocal length around the normal of the housing surface allows us to encode the refractive projection with a compact representation. We show that this model realizes an efficient forward projection computation and a linear extrinsic calibration in water. Evaluations using synthesized and real data demonstrate the performance quantitatively and qualitatively.
Vergleichende Untersuchungen über die Auslösung der Thrombocytenaggregation durch Prokollagen, Serotonin und ADP und ihre gegenseitige Beeinflussung (1972)

Die Thrombusbildung beginnt in der Regel mit der gesteigerten Thrombocytenaggregation. Der genaue Mechanismus der Plättchenaggregation in vitro und in vivo ist bisher noch unbekannt. Es erschien uns daher notwendig, Untersuchungen zum Wirkungsmechanismus einiger, die Aggregation induzierender Substanzen durchzuführen.
A Novel Approach to the Use of Subgingival Controlled‐Release Chlorhexidine Delivery in Chronic Periodontitis: A Randomized Clinical Trial (2011)

The use of CHX chips before and immediately after SRP improved CAL and reduced the subgingival microorganisms of the red complex in the treatment of chronic periodontitis.
Patch test results in 66 hairdressers 1973–81 (1982)

Over a period of 8 years, 66 hairdresser patients were patch tested to the North American Contact Dermatitis Group screening trays, to a hairdressers' screening tray or to both trays. Paraphenylenediamine (PPD) produced positive reactions in 45% and nickel sulphate in 27% of the patients tested. Apart from the PPD substances and glyceryl monothioglycollate, other chemicals tested produced allergic reactions in no more than 4/66 (6%) patients.
Effects of regenerator geometry on the Stirling engine performance. 2nd Report, Regenerator diameter. (1990)

Experimental engine performance has been measured for nine species of regenerators. Three stacked wire gauzes with different mesh numbers combined with three regenerator containers with different diameters were used. The indicated power, pressure drop, coolant heat loss at the cooler and so on of the test engines with different regenerators were compared. The flow friction and reheat losses were compared with the calculated values determined from simple isothermal models. The theoretical indicated thermal efficiency was calculated and compared with the experimental data. Furthermore, the diameter effects on regenerator performance have been compared with the length ones presented in the 1st report. The optimum geometry of the regenerator has been examined.
Learning About Learning (1998)

Abstract THE LEARNING CURVE: ELEVATING CHILDREN'S ACADEMIC AND SOCIAL COMPETENCE. Mishne, Judith M. Northvale, NJ/Lon-don: Jason Awnson, Inc., 1996, 232pages, $30.00.
Selfie: User-defined Sensitive Memory Protection and Recovery (2019)

Different users always have different requirement for sensitive memory definition. It is not flexible for aborting program execution once detecting memory corruption. Because the users may loose some sensitive data. We presented Selfie, a hybrid solution to provide one flexible solution to protect the sensitive memory according to users' requirements in runtime. Finally, Selfie can provide one solution to decide whether execution needs to be recovered. If the memory corruption doesn't belong sensitive memory, Selfie provides symbolic solver that can help figure out whether the memory corruption can affect the sensitive memory in future.
Comparing structuring potential of pea and soy protein with gluten for meat analogue preparation (2019)

Pea protein isolate can be combined with wheat gluten into materials with a fibrous morphology using shear induced structuring combined with heating. Results are partly in-line with soy protein isolate-wheat gluten blends, but the latter yields anisotropic materials in a much broader temperature range. Both blends also have the ability to include air. Air bubbles were aligned and deformed at process conditions that gave the most pronounce fibrous products. Mechanically, the pea protein-gluten materials processed at 140 °C had a similar strength as soy protein blends. At 110 and 120 °C, the pea protein blends had a strength that was comparable to a chicken meat reference (50–100 kPa) but weaker than their counterparts with soy (220–300 kPa). Blends of pea protein-gluten show potential for preparing structured plant protein materials, but the application area might be different compared with potential applications of soy protein-gluten blends.
HTLV-1 Tax-Specific CTL Epitope–Pulsed Dendritic Cell Therapy Reduces Proviral Load in Infected Rats with Immune Tolerance against Tax (2016)

Adult T cell leukemia/lymphoma (ATL), a CD4<sup>+</sup> T cell malignancy with a poor prognosis, is caused by human T cell leukemia virus type 1 (HTLV-1) infection. High proviral load (PVL) is a risk factor for the progression to ATL. We previously reported that some asymptomatic carriers had severely reduced functions of CTLs against HTLV-1 Tax, the major target Ag. Furthermore, the CTL responses tended to be inversely correlated with PVL, suggesting that weak HTLV-1-specific CTL responses may be involved in the elevation of PVL. Our previous animal studies indicated that oral HTLV-1 infection, the major route of infection, caused persistent infection with higher PVL in rats compared with other routes. In this study, we found that Tax-specific CD8<sup>+</sup> T cells were present, but not functional, in orally infected rats as observed in some human asymptomatic carriers. Even in the infected rats with immune unresponsiveness against Tax, Tax-specific CTL epitope-pulsed dendritic cell (DC) therapy reduced the PVL and induced Tax-specific CD8<sup>+</sup> T cells capable of proliferating and producing IFN-γ. Furthermore, we found that monocyte-derived DCs from most infected individuals still had the capacity to stimulate CMV-specific autologous CTLs in vitro, indicating that DC therapy may be applicable to most infected individuals. These data suggest that peptide-pulsed DC immunotherapy will be useful to induce functional HTLV-1-specific CTLs and decrease PVL in infected individuals with high PVL and impaired HTLV-1-specific CTL responses, thereby reducing the risk of the development of ATL.
β-Arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2 (2009)

Beta-arrestins are multifunctional adaptors that mediate the desensitization, internalization, and some signaling functions of seven-transmembrane receptors (7TMRs). Agonist-stimulated ubiquitination of beta-arrestin2 mediated by the E3 ubiquitin ligase Mdm2 is critical for rapid beta(2)-adrenergic receptor (beta(2)AR) internalization. We now report the discovery that the deubiquitinating enzyme ubiquitin-specific protease 33 (USP33) binds beta-arrestin2 and leads to the deubiquitination of beta-arrestins. USP33 and Mdm2 function reciprocally and favor respectively the stability or lability of the receptor beta-arrestin complex, thus regulating the longevity and subcellular localization of receptor signalosomes. Receptors such as the beta(2)AR, previously shown to form loose complexes with beta-arrestin ("class A") promote a beta-arrestin conformation conducive for binding to the deubiquitinase, whereas the vasopressin V2R, which forms tight beta-arrestin complexes ("class B"), promotes a distinct beta-arrestin conformation that favors dissociation of the enzyme. Thus, USP33-beta-arrestin interaction is a key regulatory step in 7TMR trafficking and signal transmission from the activated receptors to downstream effectors.
Corrigenda (1974)

E. Fujita, I. Uchida, T. Fujita, N. Masaki, K. Osaka, M. Przybylska, E. M. Gopalakrishna, A. Taylor, S. Safe, D. E. Fenton, C. Nave and M. R. Truter, J. Chem. Soc., Chem. Commun., 1974, 116 DOI: 10.1039/C39740000116
A sulphur and uranium fiesta! Synthesis, structure, and characterization of neutral terminal uranium(vi) monosulphide, uranium(vi) η2-disulphide, and uranium(iv) phosphine sulphide complexes (2018)

Three new uranium species (C5Me5)2U([double bond, length as m-dash]N-2,6-iPr2-C6H3)([double bond, length as m-dash]S), (C5Me5)2U([double bond, length as m-dash]N-2,6-iPr2-C6H3)(η2-S2), and (C5Me5)2U([double bond, length as m-dash]N-2,6-iPr2-C6H3)(S[double bond, length as m-dash]PMe3) were synthesized and fully characterized by a combination of NMR, IR, and UV/vis-NIR spectroscopies, elemental analysis, and cyclic voltammetry. The solid state structures of (C5Me5)2U([double bond, length as m-dash]N-2,6-iPr2-C6H3)([double bond, length as m-dash]S) and (C5Me5)2U([double bond, length as m-dash]N-2,6-iPr2-C6H3)(η2-S2) were also determined. The compound (C5Me5)2U([double bond, length as m-dash]N-2,6-iPr2-C6H3)([double bond, length as m-dash]S) is the first neutral uranium complex with a terminal sulphido ligand, and (C5Me5)2U([double bond, length as m-dash]N-2,6-iPr2-C6H3)(S[double bond, length as m-dash]PMe3) is the first uranium compound with a coordinated phosphine sulphide ligand. The phosphine sulphide adduct, (C5Me5)2U([double bond, length as m-dash]N-2,6-iPr2-C6H3)(S[double bond, length as m-dash]PMe3), can be synthesized either by reaction of the uranium(iv) complex (C5Me5)2U([double bond, length as m-dash]N-2,6-iPr2-C6H3)(thf) with S[double bond, length as m-dash]PMe3 or by the reaction of the uranium(vi) terminal sulphido complex (C5Me5)2U([double bond, length as m-dash]N-2,6-iPr2-C6H3)([double bond, length as m-dash]S) with PMe3.
BIOLOGICAL MEASUREMENT OF ESTROGENIC ACTIVITY IN URINE AND BILE CONJUGATES WITH THE IN VITRO ER-CALUX REPORTER GENE ASSAY (2002)

Although estrogens are excreted as biologically inactive conjugates, they can be reconverted to an active form, possibly by bacteria. A simple method was developed to deconjugate estrogen metabolites present in human urine and fish bile back to active estrogens by enzymatic hydrolysis with β-glucuronidase or live Escherichia coli cells. Deconjugated extracts were tested for estrogenic activity in the in vitro stable estrogen receptor—mediated chemical-activated luciferase gene expression (ER-CALUX) assay. Estrogen glucuronides in urine obtained from human males and females were effectively converted to active forms after incubation with β-glucuronidase or E. coli. The highest estrogenic activity was found in deconjugated metabolites from urine of a pregnant woman, in which levels up to 3,000 nmol estradiol equivalents per liter of urine were found after overnight incubation of urine with E. coli. Bile sampled from male bream and flounder from various freshwater and marine locations was also deconjugated and a good correlation was found between high biliary estrogenic activity and elevated levels of xenoestrogenic activity in surface water as well as in plasma vitellogenin. Therefore, the measurement of deconjugated bile could form a useful (indirect) biomarker for internal dose of xenoestrogens in male fish.
Structural, Bonding, and Electrochemical Properties of Perfluorinated Fullerene C70 (2001)

The synthesis of a perfluorinated compound of average composition C70F56 is described. The associated properties are examined at the molecular level and for the bulk material. It is shown that fluorination involves an expansion of the carbon frame and that the length of the resulting C−F bond is elongated to 1.45 Å and possesses an ionocovalent nature. The corresponding crystalline product has fcc symmetry related to complete orientational disorder of the fluorinated molecules. When C70F56 is used in lithium batteries, the formation of LiF results via a preliminary intercalation reaction.
Multiplexer at 5 Gbit/s for fibre-optical communication systems (1977)

A 5 Cbit/s multiplexer using a step-recovery diode, microstrip transmission delay lines and fast p-i-n diode switches has been investigated. The signal/distortion ratio is 12 dB, where most of the distortion is due to an imperfect input signal. The overall multiplexer seems to be simple enough to be adopted in highcapacity optical-fibre communication systems.
Clofarabine-associated acute kidney injury in patients undergoing hematopoietic stem cell transplant (2014)

Abstract We examined clofarabine pharmacokinetics and association with renal toxicity in 62 patients participating in a phase I-II study of clofarabine-melphalan-alemtuzumab conditioning for hematopoietic stem cell transplant (HSCT). Pharmacokinetic parameters, including clofarabine area under the concentration-time curve (AUC), maximum concentration and clearance, were measured, and patients were monitored for renal injury. All patients had normal pretreatment creatinine values, but over half (55%) experienced acute kidney injury (AKI) after clofarabine administration. Age was the strongest predictor of AKI, with older patients at greater risk (p = 0.002). Clofarabine AUC was higher in patients who developed AKI, and patients with the highest dose-normalized AUCs experienced the most severe grades of AKI (p = 0.01). Lower baseline renal function, even when normal, was associated with lower clofarabine clearance (p = 0.008). These data suggest that renal-adjustment of clofarabine dosing should be considered for older and at-risk patients even when renal function is ostensibly normal.
A Review of the Biology and Ecology of the Quagga Mussel (Dreissena bugensis), a Second Species of Freshwater Dreissenid Introduced to North America (1996)

SYNOPSIS. North America's Great Lakes have recently been invaded by two genetically and morphologically distinct species of Dreissena. The zebra mussel (Dreissena polymorpha) became established in Lake St. Clair of the Laurentian Great Lakes in 1986 and spread throughout eastern North America. The second dreissenid, termed the quagga mussel, has been identified as Dreissena bugensis Andrusov, 1897. The quagga occurs in the Dnieper River drainage of Ukraine and now in the lower Great Lakes of North America. In the Dnieper River, populations of D. polymorpha have been largely replaced by D. bugensis; anecdotal evidence indicates that similar trends may be occurring in the lower Laurentian Great Lakes. Dreissena bugensis occurs as deep as 130 m in the Great Lakes, but in Ukraine is known from only 0–28 m. Dreissena bugensis is more abundant than D. polymorpha in deeper waters in Dneiper River reservoirs. The conclusion that North American quagga mussels have a lower thermal maximum than zebra mussels is not supported by observations made of populations in Ukraine. In the Dnieper River drainage, quagga mussels are less tolerant of salinity than zebra mussels, yet both dreissenids have acclimated to salinities higher than North American populations; eventual colonization into estuarine and coastal areas of North America cannot be ignored.
Calcium channel blocker and Rho-associated kinase activity in patients with hypertension (2010)

These findings suggest that calcium channel blocker amlodipine inhibits ROCK activity in patients with hypertension.
Metamodelling and Global Sensitivity Analysis of Models with Dependent Variables (2011)

A novel approach for metamodelling and estimation variance based sensitivity indices for models with dependent variables are presented. Both the first order and total sensitivity indices are derived as generalizations of Sobol’ sensitivity indices. Formulas and Monte Carlo numerical estimates similar to Sobol’ formulas are derived. A Gaussian copula based approach is proposed for sampling from arbitrary multivariate probability distributions. Both methods are shown to be efficient and general.
Lysis of human melanoma cells by autologous cytolytic T cell clones. Identification of human histocompatibility leukocyte antigen A2 as a restriction element for three different antigens. (1989)

From the peripheral blood of the melanoma patient (AV), we derived cytolytic T lymphocyte (CTL) clones that lysed the autologous tumor line SK-MEL-29, but not autologous EBV-B cells, K562, and other tumor targets. By immunoselection experiments it was shown that the CTL clones recognized at least three different antigens on the autologous tumor cells. We demonstrate here that these melanoma antigens are presented to the CTL in association with HLA-A2. First, HLA-A2-reactive pregnancy sera as well as an mAb against HLA-A2 inhibited the CTL lysis. Second, immunoselected melanoma subclones that were resistant to lysis by CTL clones against the three antigens described were found to lack expression of HLA-A2. By sensitizing the patient's lymphocytes against an HLA-A2- melanoma clone, we established a new series of CTL clones recognizing autologous AV melanoma cells. However, efficient lysis was only seen when target cells were pretreated with IFN-gamma. The lytic activity of these CTL was selectively inhibited by an mAb against a common HLA-B determinant. These results indicate that in addition to HLA-A2, other class I antigens are involved in the recognition of AV melanoma cells by autologous CTL.
Genome-wide association studies of cognitive and motor progression in Parkinson's disease (2020)

Background: There are currently no treatments that stop or slow the progression of Parkinson's disease (PD). Case-control genome-wide association studies (GWASs) have identified variants associated with disease risk, but not progression. Objective: To identify genetic variants associated with PD progression in GWASs. Methods: We analysed three large, longitudinal cohorts: Tracking Parkinson's, Oxford Discovery, and the Parkinson's Progression Markers Initiative. We included clinical data for 3,364 patients with 12,144 observations (mean follow-up 4.2 years). We used a new method in PD, following a similar approach in Huntington's disease, where we combined multiple assessments using a principal components analysis to derive scores for composite, motor, and cognitive progression. These scores were analysed in linear regressions in GWASs. We also performed a targeted analysis of the 90 PD risk loci from the latest case-control meta-analysis. Results: There was no overlap between variants associated with PD risk, from case-control studies, and PD age at onset versus PD progression. The APOE ϵ4 tagging variant, rs429358, was significantly associated with the rate of composite and cognitive progression in PD. No single variants were associated with motor progression. However in gene-based analysis, variation across ATP8B2, a phospholipid transporter related to vesicle formation, was nominally associated with motor progression (p=5.3 x 10^-6). Conclusions: This new method in PD improves measurement of symptom progression. We provide strong evidence that the APOE ϵ4 allele drives progressive cognitive impairment in PD. We have also reported loci of interest which need to be tested in further studies.
Affective Brain–Computer Interfaces (aBCIs): A Tutorial (2023)

A brain–computer interface (BCI) enables a user to communicate directly with a computer using only the central nervous system. An affective BCI (aBCI) monitors and/or regulates the emotional state of the brain, which could facilitate human cognition, communication, decision-making, and health. The last decade has witnessed rapid progress in aBCI research and applications, but there does not exist a comprehensive and up-to-date tutorial on aBCIs. This tutorial fills the gap. It introduces first the basic concepts of BCIs and then, in detail, the individual components in a closed-loop aBCI system, including signal acquisition, signal processing, feature extraction, emotion recognition, and brain stimulation. Next, it describes three representative applications of aBCIs, i.e., cognitive workload recognition, fatigue estimation, and depression diagnosis and treatment. Several challenges and opportunities in aBCI research and applications, including brain signal acquisition, emotion labeling, diversity and size of aBCI datasets, algorithm comparison, negative transfer in emotion recognition, and privacy protection and security of aBCIs, are also explained.