gebhart/patrepeval huggingface dataset:
Biosynthesis of granule proteins in normal human bone marrow cells. Gelatinase is a marker of terminal neutrophil differentiation (1995)

Differentiation and maturation of myeloid cells is characterized by the sequential acquisition of two distinct cytoplasmic granule subsets, azurophil granules and specific granules. We recently showed the existence of a third granule subset, gelatinase granules. To investigate whether appearance of gelatinase granules marks a further step in maturation of myeloid cells beyond the appearance of specific granules, we sorted normal human bone marrow cells into one of three groups according to maturity by centrifugation on Percoll density gradients. The biosynthesis of myeloperoxidase (MPO) (an azurophil granule marker), lactoferrin and neutrophil gelatinase-associated lipocalin NGAL (specific granules markers) and gelatinase was then studied in each of these groups. We found that gelatinase was synthesized mainly in the group containing band cells and segmented cells. This contrasted with lactoferrin and NGAL, which were synthesized almost exclusively in the group containing myelocytes and metamyelocytes, and with MPO, which was mainly synthesized in the group containing myeloblasts and promyelocytes. Immunocytochemistry was in full agreement with the biosynthesis data, and showed that gelatinase appears in band cells, whereas NGAL and lactoferrin both appear in myelocytes. Thus, acquisition of gelatinase granules marks a step in neutrophil differentiation beyond the appearance of specific granules.
Complete intervals for D-stability of single-parameter polynomially-dependent matrices — Generalization of the stability feeler (2010)

In this paper we study the robust P-stability of parameter-dependent matrices. We propose a method based on generalization of the stability feeler. The proposed method enables one to derive complete ©-stability intervals for a class of single-parameter polynomially-dependent matrices.
New high-frequency MJTCs of novel design on fused silica substrates (2012)

We are presently deploying new thin-film multijunction thermal converters fabricated on fused silica substrates for highly accurate ac voltage measurements at frequencies up to 100 MHz. Devices fabricated thus far include both bifilar and coaxial designs, and are being tested as new standards in the 2 V to 5 V range. We report on the performance of these new MJTCs, describe present work to improve their performance and discuss future goals.
Models of Information Processing in the Basal Ganglia (1994)

This book brings together the biology and computational features of the basal ganglia and their related cortical areas along with select examples of how this knowledge can be integrated into neural network models. Recent years have seen a remarkable expansion of knowledge about the anatomical organization of the part of the brain known as the basal ganglia, the signal processing that occurs in these structures, and the many relations both to molecular mechanisms and to cognitive functions. This book brings together the biology and computational features of the basal ganglia and their related cortical areas along with select examples of how this knowledge can be integrated into neural network models. Organized in four parts - fundamentals, motor functions and working memories, reward mechanisms, and cognitive and memory operations - the chapters present a unique admixture of theory, cognitive psychology, anatomy, and both cellular- and systems- level physiology written by experts in each of these areas. The editors have provided commentaries as a helpful guide to each part. Many new discoveries about the biology of the basal ganglia are summarized, and their impact on the computational role of the forebrain in the planning and control of complex motor behaviors discussed. The various findings point toward an unexpected role for the basal ganglia in the contextual analysis of the environment and in the adaptive use of this information for the planning and execution of intelligent behaviors. Parallels are explored between these findings and new connectionist approaches to difficult control problems in robotics and engineering. Contributors James L. Adams, P. Apicella, Michael Arbib, Dana H. Ballard, Andrew G. Barto, J. Brian Burns, Christopher I. Connolly, Peter F. Dominey, Richard P. Dum, John Gabrieli, M. Garcia-Munoz, Patricia S. Goldman-Rakic, Ann M. Graybiel, P. M. Groves, Mary M. Hayhoe, J. R. Hollerman, George Houghton, James C. Houk, Stephen Jackson, Minoru Kimura, A. B. Kirillov, Rolf Kotter, J. C. Linder, T. Ljungberg, M. S. Manley, M. E. Martone, J. Mirenowicz, C. D. Myre, Jeff Pelz, Nathalie Picard, R. Romo, S. F. Sawyer, E Scarnat, Wolfram Schultz, Peter L. Strick, Charles J. Wilson, Jeff Wickens, Donald J. Woodward, S. J. Young Bradford Books imprint
Production of Eicosapentaenoic Acid (20:5 n-3) by Vibrio pelagius Isolated from Turbot ( Scophthalmus maximus (L.)) Larvae (1992)

Fourteen bacterial strains isolated from turbot, Scophthalmus maximus (L.), larvae were screened for eicosapentaenoic acid (20:5 n-3) (EPA) production. Gas chromatography analysis revealed that one bacterial species, Vibrio pelagius, contained a high proportion of EPA in cellular lipid. This finding was confirmed by gas chromatography-mass spectrometry analysis. A higher concentration of EPA was detected when the bacterium was cultured at 4 degrees C.
Fundamental aspects of the structural and electrolyte properties of Li2OHCl from simulations and experiment (2017)

Solid-state electrolytes that are compatible with high-capacity electrodes are expected to enable the next generation of batteries. As a promising example, ${\mathrm{Li}}_{2}\mathrm{OHCl}$ was reported to have good ionic conductivity and to be compatible with a lithium metal anode even at temperatures above $100{\phantom{\rule{0.16em}{0ex}}}^{\ensuremath{\circ}}\mathrm{C}$. In this work, we explore the fundamental properties of ${\mathrm{Li}}_{2}\mathrm{OHCl}$ by comparing simulations and experiments. Using calculations based on density functional theory, including both static and dynamic contributions through the quasiharmonic approximation, we model a tetragonal ground state, which is not observed experimentally. An ordered orthorhombic low-temperature phase was also simulated, agreeing with experimental structural analysis of the pristine electrolyte at room temperature. In addition, comparison of the ordered structures with simulations of the disordered cubic phase provide insight into the mechanisms associated with the experimentally observed abrupt increase in ionic conductivity as the system changes from its ordered orthorhombic to its disordered cubic phase. A large Haven ratio for the disordered cubic phase is inferred from the computed tracer diffusion coefficient and measured ionic conductivity, suggesting highly correlated motions of the mobile Li ions in the cubic phase of ${\mathrm{Li}}_{2}\mathrm{OHCl}$. We find that the OH bond orientations participate in gating the Li ion motions which might partially explain the predicted Li-Li correlations.
Evaluation of Performance of Full-Depth Reclamation Mixes (2002)

The full-depth reclamation (FDR) process consists of reclaiming all of an asphalt-bound section along with a predetermined amount of underlying base, with some additive. The objectives of this study were to determine the suitable compactive effort for designing FDR mixes, evaluate the benefits of using different types of additives in terms of improvement of pavement life, and determine suitable structural numbers for pavements recycled with different types of additives. The scope of work for this part of the study consisted of conducting falling-weight deflectometer (FWD) tests, testing an existing pavement before FDR, sampling of materials during FDR, determining the density of in-place material after compaction, compacting of loose mix in the laboratory, determining the density of the compacted samples, conducting FWD testing on the finished pavement, determining the resilient modulus of in-place cores, and analyzing the data to determine the suitable number of gyrations, improvement in pavement life, and structural numbers. It was concluded that samples should be compacted to 50 gyrations during mix design and that a minimum of 98% of density of in-place loose mix samples, compacted to 50 gyrations, should be achieved in the field at the end of compaction. Cost comparison showed that for the options considered in this study, recycling with emulsion (3.4%) and lime (2%) is the most cost-effective option. A visual evaluation of recycled sections after one year showed no significant distress in any section except the one with water as additive, in which a moderate amount of edge cracking was noted.
A Facade Tracking System for Outdoor Augmented Reality (2010)

We describe a real-time facade tracking system that uses, as setup information, only two images of a facade,\ncaptured on the moment. No more previous information is needed, such as a facade 3D model, dimensions or\naspect ratio. Feature points and their local descriptors are extracted from that pair of images and used during the\ndetection and tracking of the facade. Additionally, parallax and topological information is also used in order to\nincrease the overall robustness of the tracking process. Experiments show that the system can detect and track a\nwide variety of facades, including those that are not entirely planar, partially occluded or have few distinguishable\nvisual landmarks. The reliance on on-the-spot information, alone, makes this system useful for Outdoor\nAugmented Reality applications, in an Anywhere Augmentation urban context.
A LOCAL MODE THEORY FOR VIBRATIONAL ABSORPTION AND CIRCULAR DICHROISM (1986)

Since their earliest days, humans have been struggling with infectious diseases. Caused by viruses, bacteria, protozoa, or even higher organisms like worms, these diseases depend critically on numerous intricate interactions between parasites and hosts, and while we have learned much about these interactions, many details are still obscure. It is evident that the combined host-parasite dynamics constitutes a complex system that involves components and processes at multiple scales of time, space, and biological organization. At one end of this hierarchy we know of individual molecules that play crucial roles for the survival of a parasite or for the response and survival of its host. At the other end, one realizes that the spread of infectious diseases by far exceeds specific locales and, due to today's easy travel of hosts carrying a multitude of organisms, can quickly reach global proportions. The community of mathematical modelers has been addressing specific aspects of infectious diseases for a long time. Most of these efforts have focused on one or two select scales of a multi-level disease and used quite different computational approaches. This restriction to a molecular, physiological, or epidemiological level was prudent, as it has produced solid pillars of a foundation from which it might eventually be possible to launch comprehensive, multi-scale modeling efforts that make full use of the recent advances in biology and, in particular, the various high-throughput methodologies accompanying the emerging -omics revolution. This special issue contains contributions from biologists and modelers, most of whom presented and discussed their work at the workshop From within Host Dynamics to the Epidemiology of Infectious Disease, which was held at the Mathematical Biosciences Institute at Ohio State University in April 2014. These contributions highlight some of the forays into a deeper understanding of the dynamics between parasites and their hosts, and the consequences of this dynamics for the spread and treatment of infectious diseases.
Evidence of a Functional Relationship between the Nucleus Accumbens Shell and Lateral Hypothalamus Subserving the Control of Feeding Behavior (1999)

Inhibition of neurons in the nucleus accumbens shell (AcbSh) with local injections of GABA agonists or glutamate antagonists elicits an intense, but specific, feeding response resembling that seen after stimulation of the lateral hypothalamus (LH). To help characterize the contribution of the LH to the expression of AcbSh-mediated feeding, we used the immunohistochemical detection of the nuclear protein Fos to determine whether inhibition of AcbSh cells results in an activation of LH neurons. Injections of the GABA(A) agonist muscimol into the AcbSh greatly increased the number of cells exhibiting Fos-like immunoreactivity in the LH, as well as in the lateral septum, paraventricular hypothalamic nucleus, ventral tegmental area, substantia nigra pars compacta, and nucleus of the solitary tract. Blocking activation of LH neurons with the selective NMDA receptor blocker D(-)-AP-5 is known to suppress deprivation-induced feeding. We found that injections of D(-)-AP5 into the LH also dose-dependently suppressed AcbSh-mediated feeding. It is likely that inhibition of GABAergic neurons in the AcbSh is responsible for eliciting this feeding. If a behaviorally relevant GABAergic projection terminates in the LH, we should be able to mimic the effects seen after inhibition of the projection neurons by applying a GABA receptor blocker to the area. However, injections of the GABA(A) receptor blocker bicuculline or the GABA(B) receptor blocker saclofen did not significantly affect food intake. Thus, it appears that the expression of the feeding response depends on an NMDA-preferring receptor-mediated activation of LH neurons and is not the result of disinhibiting LH cells by disrupting transmission at GABA synapses.
Low-Temperature Structure and Dynamics in Cu2Se (2015)

We report 63Cu and 65Cu NMR on Cu2Se, a superionic conductor of interest for thermoelectric and other applications. Results demonstrate an initial appearance of ionic hopping in a narrow temperature range above 100 K, coinciding with the recently observed low-temperature phase transition. At room temperature and above, this goes over to rapid Cu-ion hopping and a single motionally narrowed line both above and below the α–β structural transition. The low-temperature α′ phase exhibits a sizable metallic shift, in contrast to the high-temperature structures. The large variation in native carrier density, significantly enhanced at positions associated with Cu vacancies, indicates the strong influence of an impurity band on low-temperature electronic transport.
Phase calibration approaches for radar interferometry and imaging configurations: equatorial spread F results (2008)

Abstract. In recent years, more and more radar systems with multiple-receiver antennas are being used to study the atmospheric and ionospheric irregularities with either interferometric and/or imaging configurations. In such systems, one of the major challenges is to know the phase offsets between the different receiver channels. Such phases are intrinsic to the system and are due to different cable lengths, filters, attenuators, amplifiers, antenna impedance, etc. Moreover, such phases change as function of time, on different time scales, depending on the specific installation. In this work, we present three approaches using natural targets (radio stars, meteor-head and meteor trail echoes) that allow either an absolute or relative phase calibration. In addition, we present the results of using an artificial source (radio beacon) for a continuous calibration that complements the previous approaches. These approaches are robust and good alternatives to other approaches, e.g. self-calibration techniques using known data features, or for multiple-receiver configurations constantly changing their receiving elements. In order to show the good performance of the proposed phase calibration techniques, we present new radar imaging results of equatorial spread F (ESF) irregularities. Finally we introduce a new way to represent range-time intensity (RTI) maps color coded with the Doppler information. Such modified map allows the identification and interpretation of geophysical phenomena, previously hidden in conventional RTI maps, e.g. the time and altitude of occurrence of ESF irregularities pinching off from the bottomside and their respective Doppler velocity.
Financing Public-Private Partnership Infrastructure Projects through Tokenization-enabled Project Finance on Blockchain (2022)

Abstract Infrastructure is critical for enabling society to function and the economy to thrive. Unfortunately, there is an increasing mismatch between the need for infrastructure investment and available financing globally due to constraints on public resources and limited capacity to effectively leverage private sector co-financing in the current system. This research explores the integration of blockchain-enabled asset tokenization with public-private partnership (PPP) project finance to engage private sector resources and innovation to supplement limited public sector capacities and to leverage the inherent efficiencies in infrastructure financing. A conceptual framework of tokenization-enabled PPP project finance is proposed. The transactional and contractual structures of the blockchain-driven infrastructure financing system are illustrated and evaluated. It is found that the potential benefits can be summarized into three categories: better project management, improved bankability, and enhanced inclusivity.
Lipid-mediated Wnt protein stabilization enables serum-free culture of human organ stem cells (2017)

Wnt signalling proteins are essential for culture of human organ stem cells in organoids, but most Wnt protein formulations are poorly active in serum-free media. Here we show that purified Wnt3a protein is ineffective because it rapidly loses activity in culture media due to its hydrophobic nature, and its solubilization requires a detergent, CHAPS (3-[(3-cholamidopropyl) dimethylammonio]-1-propanesulfonate), that interferes with stem cell self-renewal. By stabilizing the Wnt3a protein using phospholipids and cholesterol as carriers, we address both problems: Wnt activity remains stable in serum-free media, while non-toxic carriers allow the use of high Wnt concentrations. Stabilized Wnt3a supports strongly increased self-renewal of organ and embryonic stem cells and the serum-free establishment of human organoids from healthy and diseased intestine and liver. Moreover, the lipophilicity of Wnt3a protein greatly facilitates its purification. Our findings remove a major obstacle impeding clinical applications of adult stem cells and offer advantages for all cell culture uses of Wnt3a protein.
Activated astrocytes: a therapeutic target in Alzheimer’s disease? (2009)

Astrocytes become activated in Alzheimer's disease, contributing to and reinforcing an inflammatory cascade. A large body of evidence suggests that by transforming from a basal to a reactive state, astrocytes neglect their neurosupportive functions, thus rendering neurons vulnerable to neurotoxins, including proinflammatory cytokines and reactive oxygen species. This review highlights three important astrocytic functions that may be impaired in neurodegenerative diseases such as Alzheimer's disease. These are: the uptake of glucose and release of lactate; the uptake of glutamate and release of glutamine; and the uptake of glutathione precursors and release of glutathione. Astrocytes could become promising targets of therapeutic intervention for Alzheimer's disease, if these compromised functions can be normalized with pharmacological agents that are specifically designed to return astrocytes to a quiescent phenotype or to supplement any factors that activated astrocytes fail to produce.
Using star tracks to determine the absolute pointing of the Fluorescence Detector telescopes of the Pierre Auger Observatory (2005)

To accurately reconstruct a shower axis from the Fluorescence Detector data it is essential to establish with high precision the absolute pointing of the telescopes. To d that they calculate the absolute pointing of a telescope using sky background data acquired during regular data taking periods. The method is based on the knowledge of bright star's coordinates that provide a reliable and stable coordinate system. it can be used to check the absolute telescope's pointing and its long-term stability during the whole life of the project, estimated in 20 years. They have analyzed background data taken from January to October 2004 to determine the absolute pointing of the 12 telescopes installed both in Los Leones and Coihueco. The method is based on the determination of the mean-time of the variance signal left by a star traversing a PMT's photocathode which is compared with the mean-time obtained by simulating the track of that star on the same pixel.
Joint appointments: the Deakin experience. (1989)

This paper explores the concept of joint appointment as a means of forming a bridge between the service sector and tertiary education systems in nursing. Joint appointments are not new, having existed in the USA and the UK in various forms since the early 1970s. The practicalities of establishing a joint appointment are described and the positive and negative aspects identified.
Detection of in vivo enzyme activity with CatalyCEST MRI (2013)

CatalyCEST MRI demonstrates that dynamic tracking of enzyme-responsive and unresponsive CEST agents during the same in vivo MRI study is feasible.
Resiliency and Change in the Indian Caste System: The Umar of U.P. (1967)

Lack of agreement on basic definitions has often bedeviled the anthropological study of Indian society. A case in point is “caste,” which has enjoyed almost as many definitions as there are students involved in its study. This multiplicity undoubtedly promotes a broadened investigation of caste phenomena, and thus ultimately increases our knowledge. But it also leads to the danger that competing definitions will masquerade as factual explanations, or that theoretically valid distinctions are lost in the rhetoric of definitional arguments. Especially in studies of the breakdown and reconstitution of caste institutions, the absence of a firm, explicit definitional base impedes evaluation of the nature, direction, and novelty of social structural change.
Mechanism of Induction of Atrioventricular Node Reentry by Simultaneous Anterograde Conduction Over the Fast and Slow Pathways (2005)

The unique induction of AVNRT by a PAC with simultaneous conduction over the FP and SP is best explained by minimal to no retrograde invasion of the SP from the anterogradely conducted fast pathway impulse, and consistent with this observation is the initiation of slow/fast AVN reentry during incremental RV pacing.