gebhart/patrepeval huggingface dataset:
Finite Element Analysis of a Wideband Microwave Tomography System for Potential Medical Imaging (2019)

In this paper, we present two in-house finite element analysis methods for a wideband microwave tomography system setup. A hybrid vector three-dimensional (3D) formulation and a scalar two-dimensional (2D) formulation of the finite element method (FEM) for the forward model in microwave imaging are proposed. Simulations with dispersive materials of the system setup are performed in CST Microwave Studio and FEM formulations. We then compare the value of the S-parameters between the data from CST and FEM both in 3D and 2D, with the results showing a good agreement at different frequencies. To that end, we introduce a convenient calibration procedure to match the S-parameters and electric field values used in reconstruction algorithms.
Scintigraphy with 99mTc-labeled heat-altered erythrocytes in diagnosing hyposplenia (2007)

Ultrasound and colloid scintigraphy show a low correlation with clearance of heat-altered erythrocytes. Only ES shows a good correlation in patients with CIBD. The clearance at 10 min already reliably determines splenic function. SLR may be determined after 10 minutes and is predictive of normal function if above 3.45 while SLR < 1.2 indicated hyposplenia.
Adsorption of carbon dioxide, acetylene, ethane, and propylene on charcoal at near room temperatures (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAdsorption of carbon dioxide, acetylene, ethane, and propylene on charcoal at near room temperaturesWalden L. S. Laukhuf and Charles A. PlankCite this: J. Chem. Eng. Data 1969, 14, 1, 48–51Publication Date (Print):January 1, 1969Publication History Published online1 May 2002Published inissue 1 January 1969https://doi.org/10.1021/je60040a016Request reuse permissionsArticle Views219Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (389 KB) Get e-Alertsclose Get e-Alerts
Effects of silver nanoparticles on human and rat embryonic neural stem cells (2015)

Silver nano-particles (Ag-NPs) are becoming increasingly prevalent in consumer products as antibacterial agents. The increased use of Ag NP-enhanced products will almost certainly increase environmental silver levels, resulting in increased exposures and the potential for increased adverse reactions including neurotoxic effects. In the present study, embryonic neural stem cells (NSCs) from human and rat fetuses (gestational day-16) were used to determine whether Ag-NPs are capable of causing developmental neurotoxicity. The NSCs were cultured in serum free medium supplemented with appropriate growth factors. On the eighth day in vitro (DIV 8), the cells were exposed to Ag-NPs at concentrations of 1, 5, 10, and 20 μg/ml for 24 h. The cultured cells then were characterized by NSC markers including nestin and SOX2 and a variety of assays were utilized to determine the effects of Ag-NPs on NSC proliferation and viability and the underlying mechanisms associated with these effects. The results indicate that mitochondrial viability (MTT metabolism) was substantially attenuated and LDH release was increased significantly in a dose-dependent manner. Ag-NPs-induced neurotoxicity was further confirmed by up-regulated Bax protein expression, an increased number of TUNEL-positively stained cells, and elevated reactive oxygen species (ROS). NSC proliferation was also significantly decreased by Ag-NPs. Co-administration of acetyl-L-carnitine, an antioxidant agent, effectively blocked the adverse effects associated with Ag-NP exposure.
Gamma-Probe Based on Scintillation Crystal and Silicon Photomultipliers for Cancer Detection (2016)

Oncological diseases have become a «plague» of XXI century. One of the most important cases of high mortality from oncological diseases is their untimely diagnosis that is linked with reluctance of people to regular medical examinations and shortage of special equipment for diseases diagnosis. Nowadays intraoperative probes for gamma radiation registration are used for local detection of areas of radiopharmaceutical accumulation in tissues. The proposed in the paper gamma-probe can be used for intraoperative diagnosis of sentinel lymph nodes and noninvasive diagnosis of superficial types of cancer. Nowadays a prototype of the gamma-probe is developed and created. This prototype consists of a detecting part and a block of electronics. Among its advantages is spatial resolution and selectivity. Portability of the device and the opportunity of control with the help of a small computer play a great role in an operating room.
ChemInform Abstract: MEGALOMICINS. 6. TERTIARY GLYCOSIDIC MACROLIDE ANTIBIOTICS. A STRUCTURAL REVISION BY CARBON‐13 NUCLEAR MAGNETIC RESONANCE AND X‐RAY CRYSTALLOGRAPHY (1978)

Abstract Anhand der Kristallstrukturanalyse des Acylderivats (I) von Megalomicin A (RG P2,2,2,) werden die Strukturen der Megalomicine A (= XK‐41‐C), B, C, und C, sowie XK‐4l‐B, revidiert.
Einfluss einer chronischen Bocavirus Infektion auf die Gen Expression bei Oropharynxkarzinomen (2019)

Es ist bekannt, dass das humane Bocavirus (HBoV1), als Erreger von Atemwegsinfektionen, latent in den infizierten Wirtszellen persitieren kann. Da HBoV pro-fibrotische und pro-kanzerogene Zytokine induziert und in kolorektalen und Lungenkarzinomen gefunden werden konnte, besteht der Verdacht, HBoV an der Kanzerogenese beteiligt ist oder zumindest als Kofaktor fungiert. Zuletzt konnte gezeigt werden, dass das adenotonsilläre Gewebe als Hauptreplikationsort von HBoV dient. Vor dem Hintergrund, dass 60% aller Oropharynxkarzinome auf dem Boden einer HPV Infektion entstehen, ist es durchaus möglich, dass eine Mitbeteiligung von chronischen HBoV Infektionen bei der Entstehung von Plattenepithelkarzinomen der Tonsillen existiert.
New pixel-shared design and split-path readout of CMOS image sensor circuits (2003)

This paper reports a CMOS active pixel sensor (APS) of 128/spl times/128 resolution designed for high quantum efficiency. This kind of image sensor can be operated under 3.3 V, and use a new structure of shared-pixel and split-path readout direction. This method has the advantage that the number of transistors in each pixel is reduced to increase the fill factor by enlarging the photo-sensing area; on the other hand, it also raises the speed of readout, and is twice as fast as traditional single direction readout. In addition, we use a delta-difference sampling (DDS) for readout circuit to suppress the fixed pattern noise (FPN). The complete CMOS image sensor is implemented based on TSMC 0.35 /spl mu/m 1P4M CMOS technology.
High temperature performance of dielectrically isolated LDMOSFET: characterization, simulation and analysis (2002)

The temperature dependence of the static parameters of the 550 V RESURF DI LDMOSFET is reported. High temperature measurements were carried out from 25/spl deg/C-200/spl deg/C at intervals of 25/spl deg/C. The parameters measured include the on-resistance, threshold voltage, transconductance, effect of substrate bias, breakdown voltage and leakage current. Accurate analytic models, supported by extensive two-dimensional numerical simulations, have been developed to explain and predict device performance.
Treatment of anxiety disorders in late life. (1997)

Anxiety disorders and symptoms in old age, although common, have received little research focus to date. A comprehensive, careful approach by the clinician to assessment and management is required because anxiety is often a comorbid condition in the elderly. Effective treatments are available and should be applied in a flexible, integrated, and specific manner.
Computer tomography imaging spectrometer with structured illumination (2003)

Previous studies [1,2] demonstrated the computed tomography imaging spectrometer’s (CTIS) usefulness in the observation of individual cellular responses across an extended field of view (FOV) and than detection of more complicated signaling cascades. In this paper, we present modified CTIS with optical sectioning capability to further advance applicability of the system. Tissue sections from nearly all organs are comprised of multiple cell types with unique functional characteristics. The problem with such samples are that they are composed of multiple cell layers, and therefore a significant blurring of fluorescence output light is observed with standard optics. This not only presents problems with identification of individual cell types within the sample, but also degrades the accuracy of the spectral deconvolution due to dominance of high frequency information. Therefore sectioning capability may significantly improve tissue research. It will allow to isolate cells within selected layer, increase identification rate and improve accuracy of the spectrum reconstruction.
Study on Optimization of Tissue Culture System of Saussurea involucrata Kar.& Kir. (2007)

In present study,the regeneration system of tissue culture of Saussurea involucrata Kar. Kir.was discussed by using roots,shoots,and leaves of sterile seedling of Saussurea involucrata Kar. Kir.as the explant.Results showed: MS+6-BA 0.1 mg/L+NAA 2.0 mg/L medium was effective for calli induced; Shoots were induced with MS+6-BA 0.4 mg/L+NAA 0.05 mg/L+LH 500 mg/L medium;and roots were formed on 1/4 MS + NAA 0.3 medium.
Design and Performance of a Multi-Point Scan Confocal Microendoscope (2014)

Confocal fluorescence microendoscopy provides high-resolution cellular-level imaging via a minimally invasive procedure, but requires fast scanning to achieve real-time imaging <i>in vivo</i>. Ideal confocal imaging performance is obtained with a point scanning system, but the scan rates required for <i>in vivo</i> biomedical imaging can be difficult to achieve. By scanning a line of illumination in one direction in conjunction with a stationary confocal slit aperture, very high image acquisition speeds can be achieved, but at the cost of a reduction in image quality. Here, the design, implementation, and experimental verification of a custom multi-point aperture modification to a line-scanning multi-spectral confocal microendoscope is presented. This new design improves the axial resolution of a line-scan system while maintaining high imaging rates. In addition, compared to the line-scanning configuration, previously reported simulations predicted that the multi-point aperture geometry greatly reduces the effects of tissue scatter on image quality. Experimental results confirming this prediction are presented.
Hardware Architecture for Ultra-Wideband Channel Impulse Response Measurements Using Compressed Sensing (2020)

We propose a compact hardware architecture for measuring sparse channel impulse responses (IR) by extending the M-Sequence ultra-wideband (UWB) measurement principle with the concept of compressed sensing. A channel is excited with a periodic M-sequence and its response signal is observed using a Random Demodulator (RD), which observes pseudo-random linear combinations of the response signal at a rate significantly lower than the measurement bandwidth. The excitation signal and the RD mixing signal are generated from compactly implementable Linear Feedback Shift registers (LFSR) and operated from a common clock. A linear model is derived that allows retrieving an IR from a set of observations using Sparse-Signal-Recovery (SSR). A Matrix-free model implementation is possible due to the choice of synchronous LFSRs as signal generators, resulting in low computational complexity. For validation, real measurement data of a time-variant channel containing multipath components is processed by simulation models of our proposed architecture and the classic M-Sequence method. We show successful IR recovery using our architecture and SSR, outperforming the classic method significantly in terms of IR measurement rate. Compared to the classic method, the proposed architecture allows faster measurements of sparse time-varying channels, resulting in higher Doppler tolerance without increasing hardware or data stream complexity.
An innovative approach to induce cross-protective immunity against porcine reproductive and respiratory syndrome virus in the lungs of pigs through adjuvanted nanotechnology-based vaccination (2014)

Porcine reproductive and respiratory syndrome (PRRS) is an economically devastating respiratory disease of pigs. The disease is caused by the PRRS virus (PRRSV), an Arterivirus which is a highly mutating RNA virus. Widely used modified live PRRSV vaccines have failed to prevent PRRS outbreaks and reinfections; moreover, safety of the live virus vaccines is questionable. Though poorly immunogenic, inactivated PRRSV vaccine is safe. The PRRSV infects primarily the lung macrophages. Therefore, we attempted to strengthen the immunogenicity of inactivated/killed PRRSV vaccine antigens (KAg), especially in the pig respiratory system, through: 1) entrapping the KAg in biodegradable poly(lactic-co-glycolic acid) nanoparticles (NP-KAg); 2) coupling the NP-KAg with a potent mucosal adjuvant, whole cell lysate of Mycobacterium tuberculosis (M. tb WCL); and 3) delivering the vaccine formulation twice intranasally to growing pigs. We have previously shown that a single dose of NP-KAg partially cleared the challenged heterologous PRRSV. Recently, we reported that NP-KAg coupled with unentrapped M. tb WCL significantly cleared the viremia of challenged heterologous PRRSV. Since PRRSV is primarily a lung disease, our goal in this study was to investigate lung viral load and various immune correlates of protection at the lung mucosal surfaces and its parenchyma in vaccinated heterologous PRRSV-challenged pigs. Our results indicated that out of five different vaccine-adjuvant formulations, the combination of NP-KAg and unentrapped M. tb WCL significantly cleared detectable replicating infective PRRSV with a tenfold reduction in viral RNA load in the lungs, associated with substantially reduced gross and microscopic lung pathology. Immunologically, strong humoral (enhanced virus neutralization titers by high avidity antibodies) and cell-mediated immune responses (augmented population of interferon-γ secreting CD4(+) and CD8(+) lymphocytes and reduced secretion of immunosuppressive cytokines) in the lungs were observed. In conclusion, combination of NP-KAg and soluble M. tb WCL elicits broadly cross-protective anti-PRRSV immunity in the pig respiratory system.
Expedition 402 Scientific Prospectus: Tyrrhenian Continent–Ocean Transition (2023)

A tenet of plate tectonics is that divergent plates cause the asthenospheric mantle to ascend, decompress, and melt, producing new magmatic crust.However, drilling west of Iberia in the 1980s discovered a continent-ocean transition (COT) made of exposed mantle, revising models of lithospheric thinning and melt generation and defining magma-poor margins.A long-standing argument about mantle in COTs concerns its nature as either subcontinental or being exhumed during ultraslow seafloor spreading.Additionally, two models attribute the apparent lack of melts either to slow extension resulting in low ascent rates with enhanced asthenospheric cooling and reduced melt production or to upwelling mantle originally too depleted to produce a significant melt fraction.The debate on COT models is limited by the scarce evidence obtained in ultradeepwater drilling, restricted to a few basement highs.Thus, 30 y after its discovery, the nature and genesis of COTs is still controversial.The comparatively shallow water depth and thin sediment cover of the Tyrrhenian Sea provide an optimal location to test COT formation models by drilling.The Tyrrhenian is the only example where extensive modern geophysical data has accurately mapped basement domains of a conjugate pair of COTs.They can be characterized with unprecedented detail in a single drilling expedition to study the time and space evolution of COT processes.Expedition 402 will drill two perpendicular transects.An east-west transect will target the progression from magmatic crust to exhumed mantle; a north-south transect will map the fault zone that exhumed the mantle.Drilling will sample the complete sediment section including Messinian deposits, the sediment/basement interface, the mantle, the associated magmas, and the products of syntectonic, and possibly ongoing, fluid-rock interactions to evaluate the hydrosphere-lithosphere geochemical exchange and potential related ecosystems.
Efficiently Answering Technical Questions — A Knowledge Graph Approach (2017)

More and more users prefer to ask their technical questions online. For machines, understanding a question is nontrivial. Current approaches lack explicit background knowledge.In this paper, we introduce a novel technical question understanding approach to recommending probable solutions to users. First, a knowledge graph is constructed which contains abundant technical information, and an augmented knowledge graph is built on the basis of the knowledge graph, to link the knowledge graph and documents. Then we develop a light weight question driven mechanism to select candidate documents. To improve the online performance, we propose an index-based random walk to support the online search. We use comprehensive experiments to evaluate the effectiveness of our approach on a large scale of real-world query logs. Our system outperforms main-stream search engine and the state-of-art information retrieval methods. Meanwhile, extensive experiments confirm the efficiency of our index-based online search mechanism.
THE CORRELATION OF MIXED LEUKOCYTE CULTURE RESPONSES WITH KIDNEY ALLOGRAFT SURVIVAL (1971)

Sullivan, C Eugend; Stevens, Lawrence E.; Main, Raymond K.1; Jones, Marjorie J.; Reemtsma, Keith Author Information
[P2S10]4-: A Novel Polythiophosphate Anion Containing a Tetrasulfide Fragment (2001)

The novel polythiophosphate anion [P2S10]4- adopts two different conformations in the structure of Cs4P2S10; these consist of two PS4 tetrahedra connected via a disulfide, giving rise to a S42- fragment. Cs4P2S10 has been characterized by single-crystal X-ray diffraction, differential thermal analysis, Raman, optical diffuse reflectance, and 31P solid-state NMR spectroscopy. This new salt may be useful as a starting material for solid-state reactions or for developing the solution coordination chemistry of this potential ligand.
The international system for staging lung cancer (2000)

The International System for Staging Lung Cancer is a consistent, reproducible classification for the anatomic extent of disease in patients with lung cancer. A revision of the system in use since 1986 included modifications of the rules for stage grouping the TNM (T-primary tumor, N-regional lymph nodes, and M-distant metastasis) anatomic subsets. More specific stage categories and consistency for reporting the end results for Stage I, Stage II, and Stage IIIA disease are provided. Survival data support the revised categories and confirm the significant relationship between the extent of the disease and prognosis for patients with this disease.
Renin-angiotensin and vasopressin in the development of salt-induced hypertension (1988)

The purpose of this study was to assess the participation and interaction of the renin-angiotensin system and vasopressin in the early stages of the development of salt-induced hypertension. Subtotally nephrectomized rats, fed 1% saline, were treated over a 10-day period with either an antivasopressor V1 antagonist (by osmotic minipump) or an angiotensin converting enzyme inhibitor (either captopril or ramipril, given daily by oral gavage), or a combination of the two modes of treatment. Surprisingly, only ramipril (either alone or in combination with the V1 antagonist) could prevent the development of hypertension in these animals. Our data would not permit conclusion as to whether the different capacity of these agents to prevent salt-induced hypertension was due to a different degree of penetration into the central nervous system, or to some other property.
Congestion control for high bandwidth-delay product networks (2002)

Theory and experiments show that as the per-flow product of bandwidth and latency increases, TCP becomes inefficient and prone to instability, regardless of the queuing scheme. This failing becomes increasingly important as the Internet evolves to incorporate very high-bandwidth optical links and more large-delay satellite links.To address this problem, we develop a novel approach to Internet congestion control that outperforms TCP in conventional environments, and remains efficient, fair, scalable, and stable as the bandwidth-delay product increases. This new eXplicit Control Protocol, XCP, generalizes the Explicit Congestion Notification proposal (ECN). In addition, XCP introduces the new concept of decoupling utilization control from fairness control. This allows a more flexible and analytically tractable protocol design and opens new avenues for service differentiation.Using a control theory framework, we model XCP and demonstrate it is stable and efficient regardless of the link capacity, the round trip delay, and the number of sources. Extensive packet-level simulations show that XCP outperforms TCP in both conventional and high bandwidth-delay environments. Further, XCP achieves fair bandwidth allocation, high utilization, small standing queue size, and near-zero packet drops, with both steady and highly varying traffic. Additionally, the new protocol does not maintain any per-flow state in routers and requires few CPU cycles per packet, which makes it implementable in high-speed routers.
Chromatin condensation modulates access and binding of nuclear proteins (2009)

The condensation level of chromatin is controlled by epigenetic modifications and associated regulatory factors and changes throughout differentiation and cell cycle progression. To test whether changes of chromatin condensation levels per se affect access and binding of proteins, we used a hypertonic cell treatment. This shift to hyperosmolar medium increased nuclear calcium concentrations and induced a reversible chromatin condensation comparable to the levels in mitosis. However, this condensation was independent of mitotic histone H3 serine 10 phosphorylation. Photobleaching and photoactivation experiments with chromatin proteins-histone H2B-GFP and GFP-HP1alpha-before and after induced chromatin condensation demonstrated that hypercondensation reduced their dissociation rate and stabilized their chromatin binding. Finally, measuring the distribution of nucleoplasmic proteins in the size range from 30 to 230 kDa, we found that even relatively small proteins like GFP were excluded from highly condensed chromatin in living cells. These results suggest that structural changes in condensed chromatin by themselves affect chromatin access and binding of chromatin proteins independent of regulatory histone modifications.-Martin, R. M., Cardoso, M. C. Chromatin condensation modulates access and binding of nuclear proteins.