gebhart/patrepeval huggingface dataset:
An investigation of millimeter wave switches based on shunt transistors including SPDT SWITCH MMICs up to 300 GHz (2016)

This paper reports on a design study for millimeter wave single-pole multiple-throw switches, which are based on shunt transistors. For the investigation of an optimized design flow this study focuses on the three main steps of a millimeter wave switch design: identifying the optimum transistor gate width, large signal modeling of shunt transistors and the MMIC design. Based on the investigations of the optimum transistor gate width, it will be shown that insertion loss and output signal dynamic of a switch are directly correlated to the on-resistance of the utilized semiconductor technology. To prove the feasibility of this study, two RF SPDT switch MMICs, operating in the frequency range from 53 to 150 GHz and from 200 to 330 GHz, respectively, were designed and fabricated. Both switches show low insertion loss, high output signal dynamic, high yield and good agreement to the S-parameter simulations, based on the proposed shunt FET model. The proposed W-band and H-band SPDT switch MMICs achieve an insertion loss of 2 dB and 1.7 dB, respectively, and an output signal dynamic of up to 47 and 20 dB, respectively.
Measurement and evaluation of head tracked auto-stereoscopic displays (2011)

This paper describes objective and subjective display-related measurement methods to evaluate the performance of a laser illuminated head tracked auto-stereoscopic display. Essential characteristics are speckle, exit pupils and crosstalk. The described methods are used to evaluate a first prototype of an auto-stereoscopic display developed within the European Union-funded HELIUM3D project.
Precision plastics and LCD display backlighting (1995)

A precisely molded acrylic lightpipe is combined with micro-structured films, reflective films, adhesives, and other mechanical components in the construction of a thin, high performance LCD backlight. We focus here on the manufacturing issues associated with the injection molded lightpipe.
Proceedings of the Wireless Health 2014 on National Institutes of Health (2014)

With the proliferation of environmental sensor networks, real-time, quantitative, and localized pollutant information has become available for a few big cities. Several mobile apps have been developed to bring this information to the user 24/7. In ...
Tidal response variation and recovery following the Wenchuan earthquake from water level data of multiple wells in the nearfield (2013)

An important dataset to emerge from the Wenchuan earthquake Fault Scientific Drilling project is direct measurement of the permeability evolution of a fault zone. In order to provide context for this new observation, we examined the evolution of tidal responses in the nearfield region (within ~1.5 fault lengths) at the time of the mainshock. Previous work has shown that seismic waves can increase permeability in the farfield, but their effects in the nearfield are more difficult to discern. Close to an earthquake, hydrogeological responses are generally a combination of static and dynamic stresses. In this work, we examine the well water level data in the region of the large Mw7.9 Wenchuan earthquake and use the phase shift of tidal responses as a proxy for the permeability variations over time. We then compare the results with the coseismic water level pattern in order to separate out the dynamic and static effects. The coseismic water level pattern for observed steps coincident with the Wenchuan mainshock mainly tracks the expected static stress field. However, most of the wells that have resolvable tidal responses show permeability enhancement after this large earthquake regardless of whether the coseismic response for the well water level is increasing or decreasing, indicating permeability enhancement is a distinct process from static poroelastic strain. © 2013 Elsevier B.V.
Flow cytometry analysis of CD11c-positive peripheral blood mononuclear cells in horses (2022)

Horses have played a prominent role in shaping our modern world, with important effects on health. Unfortunately, better characterization of the horse immune system is still needed. In this report, using flow cytometry techniques, four monoclonal antibodies against horse CD11c integrin were characterized and described for their ability to provide a positive recognition signal in peripheral blood mononuclear cells. Further immune cell phenotype experiments were performed using MHC-II, CD14, TLR4 and the specific anti-horse CD11c monoclonal antibody (1C4). With this staining panel, it was possible to detect a cell population defined by CD11c<sup>+</sup>MHC-II<sup>+</sup>TLR4<sup>+</sup>CD14<sup>low</sup>, which could be considered as putative dendritic cells. This manuscript shows that a new monoclonal antibody (1C4) can be used for the characterization of dendritic cells and their different lineages, opening the possibility of better understanding the mechanisms of immunity in horses.
The potential role of insulin analogues in the treatment of children and adolescents with Type 1 diabetes mellitus. (2001)

The main therapeutic challenge in the treatment of Type 1 diabetes is maintenance of near-normoglycaemia in order to prevent long-term complications and avoid hypoglycaemia. This goal is relevant from the onset of the disease and is feasible if physiological models of insulin replacement are used and patients are educated in the strategy of intensive insulin therapy. Although the use of available insulins within a multiple injection regimen has improved, metabolic control it is still far from being optimal. The recent introduction of insulin analogues with a short- and long-acting profile seems promising in improving metabolic control and quality of care. Insulin lispro and insulin aspart, the short-acting insulin analogues offer a better post-prandial profile, while insulin glargine the new long-acting insulin analogue might provide better overnight control. In fact, the theoretical combination of an acute prandial insulin peak with a flat interprandial and overnight plasma profile would closely mimic the 24-hr insulin profile of non-diabetic individuals. This would possibly lead to lower post-prandial blood glucose excursion and better fasting blood glucose associated with minimal risk of hypoglycaemia. The possible reduction of hypoglycaemia is especially important in children as recurrent episodes might represent a potential risk for cognitive impairment. However, recent clinical research on the short-acting insulin analogues demonstrates the difficulties of translating these theoretical benefits into clinical relevant advantages. This might happen to other insulin analogues and requires further and larger studies in order to fully exploit the theoretical advantages of insulin analogues in the paediatric population. Safety issues should also be carefully monitored when introducting analogues in long-term therapy.
Soluble Narrow Band Gap and Blue Propylenedioxythiophene-Cyanovinylene Polymers as Multifunctional Materials for Photovoltaic and Electrochromic Applications (2006)

A family of soluble narrow band gap donor-acceptor conjugated polymers based on dioxythiophenes and cyanovinylenes is reported. The polymers were synthesized using Knoevenagel polycondensation or Yamamoto coupling polymerizations to yield polymers with molecular weights on the order of 10 000-20 000 g/mol, which possess solubility in common organic solvents. Thin film optical measurements revealed narrow band gaps of 1.5-1.8 eV, which gives the polymers a strong overlap of the solar spectrum. The energetic positions of the band edges were determined by cyclic voltammetry and differential pulse voltammetry and demonstrate that the polymers are both air stable and show a strong propensity for photoinduced charge transfer to fullerene acceptors. Such measurements also suggest that the polymers can be both p- and n-type doped, which is supported by spectroelectrochemical results. These polymers have been investigated as electron donors in photovoltaic devices in combination with PCBM ([6,6]-phenyl C(61)-butyric acid methyl ester) as an electron acceptor based on the near ideal band structures designed into the polymers. Efficiencies as high as 0.2% (AM1.5) with short circuit current densities as high as 1.2-1.3 mA/cm(2) have been observed in polymer/PCBM (1:4 by weight) devices and external quantum efficiencies of more than 10% have been observed at wavelengths longer than 600 nm. The electrochromic properties of the narrow band gap polymers are also of interest as the polymers show three accessible color states changing from an absorptive blue or purple in the neutral state to a transmissive sky-blue or gray in the oxidized and reduced forms. The wide electrochemical range of electrochromic activity coupled with the strong observed changes in transmissivity between oxidation states makes these materials potentially interesting for application to electrochromic displays.
Oxytocin receptor is not required for social attachment in prairie voles (2022)

Summary Prairie voles are among a small group of mammals that display long-term social attachment between mating partners. Many pharmacological studies show that signaling via the oxytocin receptor (OxtR) is critical for the display of social monogamy in these animals. We used CRISPR-mutagenesis to independently generate three different OxtR null mutant prairie vole lines. OxtR mutants displayed social attachment such that males and females showed a behavioral preference for their mating partners over a stranger of the opposite sex when assayed using different paradigms. Mothers lacking OxtR delivered viable pups, and parents displayed care of their young and raised them to the weanling stage. Together, our studies unexpectedly reveal that OxtR-mediated signaling is genetically dispensable for social attachment, parturition, and parental behavior.
Design of a 24-week trial of empagliflozin once daily in hypertensive black/African American patients with type 2 diabetes mellitus (2017)

Results of this study will add to our understanding of the efficacy and safety of empagliflozin in self-identified black/African American patients with T2DM and hypertension. (ClinicalTrials.gov identifier: NCT02182830.).
Table S3 from OncoLoop: A Network-Based Precision Cancer Medicine Framework (2023)

&lt;p&gt;Supplementary Table 3: Transcriptomic analyses of the human patient samples A. TCGA Interactome B. SU2C Interactome C. Protein activity TCGA D. Protein Activity SU2C&lt;/p&gt;
Inhibition of Group A Streptococcus Infection by Carboxyfullerene (2001)

ABSTRACT The effect of a water-soluble trimalonic acid derivative of fullerene, carboxyfullerene, against Streptococcus pyogenes infection was tested. Pretreatment with carboxyfullerene was able to protect mice from S. pyogenes infection in an air pouch model. S. pyogenes -induced death and skin injury were inhibited dose dependently by carboxyfullerene. Administration of carboxyfullerene via the peritoneum and air pouch at 3 h post- S. pyogenes infection was able to protect 33% of mice from death. Surveys of exudates of the air pouch of carboxyfullerene-treated mice revealed that survival of infiltrating neutrophils was prolonged and that the bacteria were eliminated as a result of enhanced bactericidal activity of the neutrophils. Furthermore, carboxyfullerene was able to directly inhibit in vitro growth of S. pyogenes . These data suggest that carboxyfullerene can be considered an antimicrobial agent for group A streptococcus infection.
Interaction of anthracycline drugs with canine and bovine carrier erythrocytes. (1986)

Daunomycin interacts with canine and bovine erythrocytes making them permeable to [14C]sucrose, a nonpermeant. The drug causes the red blood cell (RBC) to swell and form an echinocyte-stomatocyte cell type. Defects in the RBC membrane were observed for murine RBC as well. Thus, daunomycin interacts with RBC such that its deleterious action would not make this drug a promising candidate for encapsulation in carrier erythrocytes. Contrary to previous reports, daunomycin easily permeates murine RBC and avidly binds to the cells; as much as 70% of the drug remains associated with normal murine RBC. Several different approaches were taken to unequivocally establish that daunomycin does not entrap in canine RBC in a classical manner. The extent of interaction of the drug with RBC does not appear to be RBC specific because similar results were obtained with canine, bovine, and murine RBC.
Prognosis following in vitro fertilization-embryo transfer (IVF-ET) in patients with elevated day 2 or 3 serum follicle stimulating hormone (FSH) is better in younger vs older patients. (2002)

Oocyte quality as evidenced by PRs following IVF-ET seems to be better in younger vs older patients despite increased basal serum FSH levels.
Real‐time tissue perfusion assessment using fluorescence imaging topography scanning system: A preclinical investigation (2022)

We have conducted preclinical studies to demonstrate the feasibility of applying the RFITS system in real-time fluorescence angiography and tissue perfusion assessment. Our system provides fluorescence/color composite images for intuitive visualization of tissue perfusion with 3D perception. The findings pave the way for future clinical translation.
Sequence-Repeat Polymorphisms Exhibit the Signature of Recombination in Lodgepole Pine Chloroplast DNA (2001)

The chloroplast genome is widely used in plant systematic studies (Olmstead and Palmer 1994), in part because it is slowly evolving and is assumed to be nonrecombining (Clegg 1993). Microsatellite markers have also been identified within this genome (Powell et al. 1995; Provan et al. 1996; Vendramin et al. 1996; Newton et al. 1999), and these markers are sufficiently variable for phylogeographic studies within a species (Schaal et al. 1998; Newton et al. 1999; Marshall, Newton, and Ritland 2001). Lack of recombination reduces homoplasy, which in turn increases the precision of phylogenetic inference in such studies. However, recently there has emerged some evidence of recombination in another organelle, the mitochondrion. Lunt and Hyman (1997) found end products of mitochondrial genome recombination in the nematode Meloidogyne javanica. Saville, Kohli, and Anderson (1998) reported a discrepancy in the expected genotypic structure of mitochondrial DNA (mtDNA) sequences in the fungus Armillaria gallica relative to expectations under purely clonal transmission, consistent with observations of mitochondrial heteroplasmy. Using both sequence and restriction fragment length polymorphism data from humans, Awadalla, Eyre-Walker, and Maynard Smith (1999) found linkage disequilibria to decrease with increasing physical distance, consistent with mtDNA recombination. Phylogenetic trees constructed using similar data contained a larger number of homoplasies than expected on the basis of simulated data, which may indicate recombination (Eyre-Walker, Smith, and Maynard Smith 1999). Biologically, mtDNA recombination in humans is feasible, since mitochondria contain the necessary enzymes (Thyagarajan, Padua, and Campbell 1996), and a few paternal mitochondria are contributed to the egg during fertilization. The human mtDNA recombination issue is, however, still the subject of much debate (see EyreWalker 2000; Ingman et al. 2000). Here, we look for signatures of recombination in the chloroplast of lodgepole pine (Pinus contorta). Lodgepole pine is common in the forests of western North America, with a climactically and edaphically diverse natural range covering over 2.6 3 107 ha. A windpollinated outcrosser and aggressive pioneer, it is thought to have colonized its present range in a north-
Review of the existing maximum residue levels for chloridazon according to Article 12 of Regulation (EC) No 396/2005 (2015)

Abstract According to Article 12 of Regulation (EC) No 396/2005, the European Food Safety Authority (EFSA) has reviewed the maximum residue levels (MRLs) currently established at European level for the pesticide active substance chloridazon. In order to assess the occurrence of chloridazon residues in plants, processed commodities, rotational crops and livestock, EFSA considered the conclusions derived in the framework of Directive 91/414/EEC as well as the European authorisations reported by Member States (incl. the supporting residues data). Based on the assessment of the available data, MRL proposals were derived and a consumer risk assessment was carried out. Although no apparent risk to consumers was identified, some information required by the regulatory framework was found to be missing. Hence, the consumer risk assessment is considered indicative only and almost all MRL proposals derived by EFSA still require further consideration by risk managers.
A New Regularization For Retinex Decomposition of Low-Light Images (2024)

International audience
Social Graph Restoration via Random Walk Sampling (2022)

Analyzing social graphs with limited data access is challenging for third-party researchers. To address this challenge, a number of algorithms that estimate structural properties via a random walk have been developed. However, most existing algorithms are limited to the estimation of local structural properties. Here we propose a method for restoring the original social graph from the small sample obtained by a random walk. The proposed method generates a graph that preserves the estimates of local structural properties and the structure of the subgraph sampled by a random walk. We compare the proposed method with subgraph sampling using a crawling method and the existing method for generating a graph that structurally resembles the original graph via a random walk. Our experimental results show that the proposed method more accurately reproduces the local and global structural properties on average and the visual representation of the original graph than the compared methods. We expect that our method will lead to exhaustive analyses of social graphs with limited data access.
Physiological properties of Pseudomonas sp. strain MT-1, denitrifier from the 11,000m-depth of Mariana Trench (2005)

In the present study, we investigated the physiological properties of Pseudomonas sp. strain MT-1 isolated from the mud of Mariana Trench. Strain MT-1 was closely related with members of the genus Pseudomonas, especially with Pseudomonas chloritidismutans and Pseudomonas stutzeri on the basis of 16S rDNA sequence. The DNA-DNA hybridization values between strain MT-1 and Pseudomonas reference strains were significantly lower than those accepted as the phylogenetic definition of a species. MT-1 had polar flagellum, and was facultative anaerobe. The growth occurred in an NaCl concentration of about 0-10% (optimum: 1-2%), in pH of about 6-10 (optimum: 7-8), and in temperature of about 4-45 °C (optimum: 32-35 °C). The G+C content of the DNA was 60.5% mol%. The major quinone was ubiquinone-9. The major fatty acid in strain MT-1 was C16:0 (hexadecanoic acid), C16:1 (hexadecenoic acid) and C18:1 (octadecenoic acid). The organism showed adaptational properties to deep-sea environment compared with the reference strains.
Hepatic Steatosis in Living Liver Donor Candidates: Preoperative Assessment by Using Breath-hold Triple-Echo MR Imaging and1H MR Spectroscopy (2014)

Either breath-hold triple-echo MR imaging or MR spectroscopy can be used to detect substantial macrovesicular steatosis in living liver donor candidates. In the future, this may allow selective biopsy in candidates who are expected to have substantial macrovesicular steatosis on the basis of MR-based hepatic fat fraction.
Acute outcomes of MitraClip therapy for mitral regurgitation in high-surgical-risk patients: emphasis on adverse valve morphology and severe left ventricular dysfunction (2010)

Mitral valve repair using the MitraClip system was shown to be feasible in patients at high surgical risk primarily determined by an adverse mitral valve morphology and/or severe LV dysfunction.
Impact of the mitochondria-targeted antioxidant MitoQ on hypoxia-induced pulmonary hypertension (2018)

Increased mitochondrial reactive oxygen species (ROS), particularly superoxide, have been suggested to mediate hypoxic pulmonary vasoconstriction (HPV), chronic hypoxia-induced pulmonary hypertension and right ventricular remodelling.We determined ROS in acute and chronic hypoxia, and investigated the effect of the mitochondria-targeted antioxidant MitoQ under these conditions.The effect of MitoQ or its inactive carrier substance, decyltriphenylphosphonium, on acute HPV (1% O<sub>2</sub> for 10 min) was investigated in isolated blood-free perfused mouse lungs. Mice exposed to chronic hypoxia (10% O<sub>2</sub> for 4 weeks) or after banding of the main pulmonary artery were treated with MitoQ or decyltriphenylphosphonium (50 mg·kg<sup>-1</sup>·day<sup>-1</sup>).Total cellular superoxide and mitochondrial ROS levels were increased in pulmonary artery smooth muscle cells but decreased in pulmonary fibroblasts in acute hypoxia. MitoQ significantly inhibited HPV and acute hypoxia-induced rise in superoxide concentration. ROS was decreased in pulmonary artery smooth muscle cells, while it increased in the right ventricle after chronic hypoxia. Correspondingly, MitoQ did not affect the development of chronic hypoxia-induced pulmonary hypertension but attenuated right ventricular remodelling after chronic hypoxia as well as after pulmonary arterial banding.Increased mitochondrial ROS of pulmonary artery smooth muscle cells mediate acute HPV, but not chronic hypoxia-induced pulmonary hypertension. MitoQ may be beneficial under conditions of exaggerated acute HPV.
Estrogen Prevents Cardiomyocyte Apoptosis through Inhibition of Reactive Oxygen Species and Differential Regulation of p38 Kinase Isoforms (2005)

From human and animal studies, estrogen is known to protect the myocardium from an ischemic insult. However, there is limited knowledge regarding mechanisms by which estrogen directly protects cardiomyocytes. In this report, we employed an in vitro model, in which cultured rat cardiomyocytes underwent prolonged hypoxia followed by reoxygenation (H/R), to study the cardioprotective mechanism of estrogen. 17-beta-estradiol (E2) acting via estrogen receptors inhibited H/R-induced apoptosis of cardiomyocytes. Mitochondrial reactive oxygen species (ROS) generated from H/R activated p38alpha MAPK, and inhibition of p38alpha with SB203580 significantly prevented H/R-induced cell death. E2 suppressed ROS formation and p38alpha activation by H/R and concomitantly augmented the activity of p38beta. Unlike p38alpha, p38beta was little affected by H/R. Dominant negative p38beta protein expression decreased E2-mediated cardiomyocyte survival and ROS suppression during H/R stress. The prosurvival signaling molecule, phosphoinositol-3 kinase (PI3K), has previously been linked to cell survival following ischemia-reperfusion injury. Here, E2-activated PI3K was found to inhibit ROS generated from H/R injury, leading to inhibition of downstream p38alpha. We further linked these signaling pathways in that p38beta was activated by E2 stimulation of PI3K. Thus, E2 differentially modulated two major isoforms of p38, leading to cardiomyocyte survival. This was achieved by signaling through PI3K, integrating cell survival mediators.