gebhart/patrepeval huggingface dataset:
Expansion of human SCID-repopulating cells under hypoxic conditions (2003)

It has been proposed that bone marrow (BM) hematopoietic stem and progenitor cells are distributed along an oxygen (O2) gradient, where stem cells reside in the most hypoxic areas and proliferating progenitors are found in O2-rich areas. However, the effects of hypoxia on human hematopoietic stem cells (HSCs) have not been characterized. Our objective was to evaluate the functional and molecular responses of human BM progenitors and stem cells to hypoxic conditions. BM lineage-negative (Lin-) CD34+CD38- cells were cultured in serum-free medium under 1.5% O2 (hypoxia) or 20% O2 (normoxia) for 4 days. Using limiting dilution analysis, we demonstrate that the absolute number of SCID-repopulating cells (SRCs) increased by 5.8-fold in hypoxic cultures compared with normoxia, and by 4.2-fold compared with freshly isolated Lin-CD34+CD38- cells. The observed increase in BM-repopulating activity was associated with a preferential expansion of Lin-CD34+CD38- cells. We also demonstrate that, in response to hypoxia, hypoxia-inducible factor-1alpha protein was stabilized, surface expression of angiogenic receptors was upregulated, and VEGF secretion increased in BM Lin-CD34+ cultures. The use of low O2 levels to enhance the survival and/or self-renewal of human BM HSCs in vitro represents an important advance and could have valuable clinical implications.
A haplotype-resolved, de novo genome assembly for the wood tiger moth ( Arctia plantaginis ) through trio binning (2020)

We present the first invertebrate genome to be assembled via trio binning. This assembly is one of the highest quality genomes available for Lepidoptera, supporting trio binning as a potent strategy for assembling heterozygous genomes. Using our assembly, we provide genomic insights into the geographic population structure of A. plantaginis.
A Survey of Public Opinion about Entomophagy in Erciyes University (2018)

Edible insects have a good potential to solve the world’s food shortage in the future, and might help reduce global hunger and malnutrition. Although entomophagy is very common in some part of the world it is still not well accepted in western countries. In order to determine the attitudes of the young generation in Erciyes University towards entomophagy and the reasons for rejecting entomophagy, a questionnaire survey on 610 participants was conducted in Erciyes University campus in 2017. Of the 610 participants randomly selected in the Erciyes University Campus area, 59.3% were females, and 40.7% were males. With regards to social factors, entomophagy was found to be influenced only by the gender. Although there is a slight neophobia detected (7%), willingness to try edible insects was found low (20%). The most given reason for rejection of entomophagy by participants was disgust factor (47%). The result shows that young generation in Turkey is not ready to consume insects as food. Presumably, this attitude will change in time with the increasing awareness about the benefits of edible insects.
Improved Approximations for the Fringing and Shielded Slab-Line Capacitances (1986)

Given the dimensions w/(b - t) and t/b for the slab-line geometry or the dimensions s/b and t/b for the fringing capacitance geometry, it is shown how the capacitances associated with each geometry can be determined accurately from new explicit expressions rather than by a computerized search. The two expansions for the nome q', in terms of the dimensions, which are essential for the calculations, are identical except for signs. Finally, comparisons are made with values of the capacitances obtained by a computerized search.
Interaction Mode of Dicumarol and Its Derivatives with Human Serum Albumin, .ALPHA.1-Acid Glycoprotein and Asialo .ALPHA.1-Acid Glycoprotein. (1992)

The interaction of dicumarol and its seven other derivatives with human serum albumin (HSA), alpha 1-acid glycoprotein (AGP) and desialylatedAGP (asialoAGP) has been investigated by circular dichroism (CD) and fluorescence. The binding parameters of dicumarol and its derivatives obtained from fluorescence almost agreed with those obtained from CD. The binding data indicated that the total binding affinities (nK) to HSA were higher than the binding affinities to AGP and asialoAGP. Hydrophobic interaction was the driving force for the binding to all the three proteins and nK values in the binding process were found to be increased with the increase of hydrophobicity of the compound. This was evidenced by the attempts taken to correlate binding affinities with partition coefficients. Both electrostatic and van der Waals interactions were not found to play any significant role in the binding of these compounds to any of these three proteins. However, in case of the AGP and asialoAGP binding, apart from the hydrophobic interaction, some other forces may be involved as evidenced from the experimental data. Binding was exothermic, entropy driven and spontaneous. The change of enthalpy (delta H degree) was compensated for by the change in entropy (delta S degree). Relative contribution of hydrophobic interactions in the binding of these compounds to HSA was higher than to AGP or asialoAGP. Sialic acid was not found to impart any significant role in the binding of these compounds to AGP.
A Comparison of Ronnel and Co-Ral Sprays for Screw-worm Control (1959)

Co-Ral ( 0 -(3-chloro-4-methylumbelliferone) 0,0 -diethyl phosphorothioate) was the first insecticide recommended by the U. S. Department of Agriculture for application as a water-base spray for the control of the screw-worm ( Callitroga hominivorax (Cqrl.)). Previously all the screw-worm control formulations were smears or solutions in volatile solvents intended for application with a paint brush or a pressurized spray applicator.
Constant-phase dual polarization MEMS-based elementary cell for electronic steerable reflectarrays (2009)

A reconfigurable radiating element for beam steering reflectarray is proposed. The elementary cell consists of a square patch slot-coupled to a coplanar transmission line, operating at 76.5 GHz, with 1-bit phase resolution (0°/180°). The control is obtained by activating two pairs of MEMS switches placed on the backside of the radiating element. Such configuration allows dual polarizations and a flat phase shift response over a broad band (theoretically unlimited). Full-wave simulations are presented for 76.5 GHz patch, whereas a demonstrator operating at 10 GHz was simulated, manufactured and tested to confirm the basic principle of operation.
Energy-Efficient Autonomous Vehicle Control Using Reinforcement Learning and Interactive Traffic Simulations (2020)

Connected and autonomous vehicles are expected to improve mobility and transportation, as well as to provide energy efficiency benefits. The integration of safety and energy efficiency aspects is challenging as there are certain tradeoffs between them, and also because the assessment of these attributes requires different time horizons. This paper illustrates the development of a controller for highway driving that, through reinforcement learning, can simultaneously address requirements of safety, comfort, performance and energy efficiency for battery electric vehicles. The training process of the decision policy exploits traffic simulations that are capable of representing the interactive behavior of vehicles in traffic based on game theory. Results indicate the potential for improved energy efficiency by adding powertrain-related states in the decision policy and by suitably defining the reward function.
Demonstrated transparent mode in nested wire arrays used for dynamic hohlraum Z pinches (2007)

The mass of the outer and inner wire array used to drive the baseline dynamic hohlraum (DH) with pedestal target [Sanford et al., Phys. Plasmas 13, 012701 (2006)] is reversed in order to determine if the nested wire array is operating in a hydrodynamic, or transparent-like mode [J. Davis et al., Appl. Phys. Lett. 70, 170 (1997)], when the outer array arrives at the radius of the inner array. In contrast to the baseline, mass reversal allows the modes to be distinguished by the difference in the timing of characteristic features of the x-ray radiation pulses in the two modes. For the reversed-mass DH, all parameters such as wire number, array radii, and target remained the same, except the diameters of the individual wires were adjusted to reverse the array masses. Measurements show unambiguously that the reversed-mass DH operates in a transparent-like mode, the outer array passing through the inner array with limited collisional interaction. Numerical simulations in the r-θ plane suggest that the underlying physics of the outer array collision with the inner between the two DHs (baseline and reversed-mass), remains similar, implying that the baseline also operates with transparency. Inflection in the rate of change of the current is measured 4–7ns after the radiation signal and is associated with the outer-inner array interaction, indicating that the rear portion of the resulting plasma shell of the outer array carries the current prior to the collision. Numerical simulations together with analytic theory describe probable dynamics of the current switching from the outer to inner array.
Properties of localized, high latitude, dayside aurora (2003)

The FUV instrument on the IMAGE spacecraft frequently observes intense ultraviolet (UV) emission from a localized dayside region poleward of the general auroral oval location. One type of these emissions has been described as the signature of direct proton precipitation into the cusp after lobe reconnection during northward interplanetary magnetic field (IMF) and high solar wind dynamic pressure periods [ Frey et al. , 2002 ]. Here we describe a completely different type of high latitude aurora, which does not show any signature of precipitating protons. It also occurs during northward IMF conditions however, only during periods of very low solar wind dynamic pressure. It occurs at a much higher geomagnetic latitude than the normal cusp location and only during periods of positive IMF B y . The intensity of the UV emission is somewhat anti‐correlated with the solar wind dynamic pressure, much in contrast to the cusp emission. The brightness of the localized emission changes rapidly on time scales between 30 and 70 minutes without corresponding changes in solar wind properties. Coincident measurements by the FAST spacecraft verify that this is not the cusp, that ion precipitation is absent in these regions, and that strong precipitation of field‐aligned accelerated electrons causes the aurora. We interpret this aurora as the optical signature of electron precipitation in the upward leg of a current system which closes the downward leg of the current system into the cusp in the ionosphere.
Microblaze (2011)

Monitoring the functional behavior of an application is an important capability that assists in exploring the performance of a target application against different SW/HW implementations. Recently, there have been efforts to exploit the ability to trace the internal signals of the soft-core processors for developing FPGA-based profiling tools to monitor programs running on these processors. However, these previously developed techniques are application-dependent, i.e., they require the designer either to edit the HDL code or the application code to obtain the desired trace information when targeting new applications. In this research, we propose an application-independent profiling technique using the MicroBlaze/FPGA platform where profiling library or user-defined functions can be achieved by tracing the unique instruction flow that distinguishes functions from each other rather than monitoring the program counter value (the addresses of the functions). Hence, modifying the application code or targeting new application does not require reconfiguring the FPGA or modifying the application code for targeting the same functions. This technique can be used to analyze the target application at the source code level, observing the dominant operations and demanded resources that characterize the system behavior. In addition, this technique can assist in selecting the appropriate processor architecture for a given application by considering MicroBlaze as a reference architecture from which the functional behavior of the target application can be mapped to the performance of other architectures.
여고생의 한국 전통음식에 관한 기호도 및 섭취빈도에 관한 연구 (1995)

대구시내 인문계, 실업계 여고생 총 420명을 대상으로 전통음식에 관한 기호도와 섭취빈도에 관한 설문조사를 실시하여 다음과 같은 결과를 얻었다. 1. 조사대상자의 일반적인 사항을 조사한 결과, 실업계 여고생의 부모보다 인문계 여고생의 부모의 총수입이 더 높게 나타났으며, 대가족의 형태와 형제 자매수는 실업계 여고생에게 유의적으로 더 높게 나타났다 2. 전통음식의 섭취빈도를 조사한 결과 인문계 여고생에게는 상대적으로 구이류의 섭취빈도가 유의적으로 높은 반면, 실업계 여고생에게는 상대적으로 면류의 섭취빈도가 유의적으로 더 높게 나타났다. 3. 된장류, 김치류, 젓갈류의 기호도와 섭취빈도를 조사한 결과, 젓갈류의 기호도와 섭취빈도가 실업계 여고생에게 높게 나타났다. 부모들의 수입정도에 따른 된장류, 김치류, 젓갈류의 기호도와 섭취빈도를 조사한 결과 수입이 높을수록 기호도와 섭취빈도가 높게 나타났다. 4. 16종의 음식종류중 먹어보았거나 조리방법까지 알고 있는 식품의 종류를 조사한 결과 인문계 여고생은 7.74개, 실업계 여고생은 6.99개로 인문계 여고생이 더 높게 나타났다. 또 이것을 Pearson상관계수로 그 요인을 비교한 결과, 부모의 수입이 부모의 나이보다 전통식품의 인지도에 더 큰 영향을 주는 것으로 나타났다. 위의 결과에서 보듯이 교육환경 즉, 가족형태, 수입 등의 사회 경제적 요인이 서로 다른 두 집단에서의 전통음식의 섭취빈도, 기호도, 인지도에 큰 영향을 주는 것을 알 수 있다. 즉 그들의 가족형태, 경제적인 수준의 차이가 전통식품의 선택, 기호도 등에 영향을 주었고, 이러한 경향은 오늘날의 식생활 변화를 대변해 준다고 볼 수 있다. 우리의 전통음식을 젊은 청소년에게 널리 인식, 보급시키기 위해서 그들을 둘러싼 사회 경제적, 교육적 환경을 더욱 자세하게 분석하고 체계적으로 접근하는 자세가 필요하다고 생각된다.
Changes of endothelin concentration in cerebrospinal fluid and plasma of patients with aneurysmal subarachnoid hemorrhage (1994)

To investigate the clinical significance of endothelin (ET), a potent vasoconstrictor peptide, in subarachnoid hemorrhage (SAH) and SAH-related cerebral vasospasm, we measured the ET-like immunoreactivity (ET-LI) in plasma and cerebrospinal fluid (CSF) obtained serially from patients with SAH due to ruptured cerebral aneurysm who underwent aneurysmal surgery. The normal ET-LI levels in plasma and CSF (n = 24) were 12.4 +/- 2.0 (mean +/- s.d.) and 9.1 +/- 1.2 pg.ml-1, respectively. Plasma ET-LI levels in patients with SAH before surgery (16.8 +/- 7.8 pg.ml-1, n = 8) were higher than the normal values (P < 0.05), and became further elevated after surgery (22.5 +/- 9.4 pg.ml-1). ET-LI levels in plasma and CSF one day after surgery were 18.7 +/- 5.5 and 18.4 +/- 6.8 pg.ml-1 (P < 0.01 vs. normal values), respectively, and declined thereafter. The plasma and CSF ET-LI levels in patients who showed symptomatic vasospasm became concomitantly elevated again. These results suggest that ET is involved in SAH-related vasospasm and raise the possibility that surgical stress influences the vasospasm.
ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responses (2003)

Exposure to genotoxic agents is a major cause of human cancer, and cellular responses to genotoxic stress are important defense mechanisms. These responses are very complex, involving many cellular factors that form an extensive signal transduction network. This network includes a protein kinase cascade that connects the detection of DNA damage to the activation of transcription factors, which in turn regulate the expression of genes involved in DNA repair, cell cycle arrest and programmed cell death (apoptosis). The mitogen-activated protein kinases are the best-studied members of the kinase cascade with an acknowledged role in the genotoxic stress response. However, the initial activation of the protein kinase cascade is not fully understood, although several protein kinases, such as ataxia telangiectasia, mutated (ATM), ATM- and Rad3-related (ATR), and DNA-dependent protein kinase (DNA-PK) in humans, are increasingly recognized for their potential roles in the sensing of DNA damage and initiating the subsequent protein kinase cascade. In this review, the properties of these three kinases are discussed and their functions in the initiation of the genotoxic stress response are explored.
cDNA cloning of Brassica napus malonyl‐CoA:ACP transacylase (MCAT) (fab D) and complementation of an E. coli MCAT mutant (1998)

The GenBank database was searched using the E. coli malonyl CoA:ACP transacylase (MCAT) sequence, for plant protein/cDNA sequences corresponding to MCAT, a component of plant fatty acid synthetase (FAS), for which the plant cDNA has not been isolated. A 272-bp Zea mays EST sequence (GenBank accession number: AA030706) was identified which has strong homology to the E. coli MCAT. A PCR derived cDNA probe from Zea mays was used to screen a Brassica napus (rape) cDNA library. This resulted in the isolation of a 1200-bp cDNA clone which encodes an open reading frame corresponding to a protein of 351 amino acids. The protein shows 47% homology to the E. coli MCAT amino acid sequence in the coding region for the mature protein. Expression of a plasmid (pMCATrap2) containing the plant cDNA sequence in Fab D89, an E. coli mutant, in MCAT activity restores growth demonstrating functional complementation and direct function of the cloned cDNA. This is the first functional evidence supporting the identification of a plant cDNA for MCAT.
Histone demethylase KDM5A regulates the ZMYND8–NuRD chromatin remodeler to promote DNA repair (2017)

Upon DNA damage, histone modifications are dynamically reshaped to accommodate DNA damage signaling and repair within chromatin. In this study, we report the identification of the histone demethylase KDM5A as a key regulator of the bromodomain protein ZMYND8 and NuRD (nucleosome remodeling and histone deacetylation) complex in the DNA damage response. We observe KDM5A-dependent H3K4me3 demethylation within chromatin near DNA double-strand break (DSB) sites. Mechanistically, demethylation of H3K4me3 is required for ZMYND8-NuRD binding to chromatin and recruitment to DNA damage. Functionally, KDM5A deficiency results in impaired transcriptional silencing and repair of DSBs by homologous recombination. Thus, this study identifies a crucial function for KDM5A in demethylating H3K4 to allow ZMYND8-NuRD to operate within damaged chromatin to repair DSBs.
Mixed matrix membranes containing MIL-53(Al) for potential application in organic solvent nanofiltration (2015)

PMIA MMMs with various amounts of MIL-53(Al) were developed through non-solvent induced phase separation and the MMMs permeance was increased dramatically while keeping high rejections in organic solvent nanofiltration.
Ether lipid metabolism by AADACL1 regulates platelet function and thrombosis (2019)

We previously reported the discovery of a novel lipid deacetylase in platelets, arylacetamide deacetylase-like 1 (AADACL1/NCEH1), and that its inhibition impairs agonist-induced platelet aggregation, Rap1 GTP loading, protein kinase C (PKC) activation, and ex vivo thrombus growth. However, precise mechanisms by which AADACL1 impacts platelet signaling and function in vivo are currently unknown. Here, we demonstrate that AADACL1 regulates the accumulation of ether lipids that impact PKC signaling networks crucial for platelet activation in vitro and in vivo. Human platelets treated with the AADACL1 inhibitor JW480 or the AADACL1 substrate 1-O-hexadecyl-2-acetyl-sn-glycerol (HAG) exhibited decreased platelet aggregation, granule secretion, Ca2+ flux, and PKC phosphorylation. Decreased aggregation and secretion were rescued by exogenous adenosine 5'-diphosphate, indicating that AADACL1 likely functions to induce dense granule secretion. Experiments with P2Y12-/- and CalDAG GEFI-/- mice revealed that the P2Y12 pathway is the predominate target of HAG-mediated inhibition of platelet aggregation. HAG itself displayed weak agonist properties and likely mediates its inhibitory effects via conversion to a phosphorylated metabolite, HAGP, which directly interacted with the C1a domains of 2 distinct PKC isoforms and blocked PKC kinase activity in vitro. Finally, AADACL1 inhibition in rats reduced platelet aggregation, protected against FeCl3-induced arterial thrombosis, and delayed tail bleeding time. In summary, our data support a model whereby AADACL1 inhibition shifts the platelet ether lipidome to an inhibitory axis of HAGP accumulation that impairs PKC activation, granule secretion, and recruitment of platelets to sites of vascular damage.
Neutralisierende Antikörperaktivität von monoklonalen Antiköpern gerichtet gegen das HCV Glykoprotein E2 isoliert aus Patienten mit spontaner Viruselimination (2016)

Eine Infektion mit dem Hepatitis C Virus (HCV) führt in den meisten Fällen zu einer chronischen Erkrankung, wohingegen nur einem kleineren Anteil der Infizierten eine Ausheilung gelingt. Eine frühe Immunantwort durch neutralisierende Antikörper (AK) kann hierbei eine entscheidende Rolle spielen.
Mitigation of thermally induced non-linear effects in silicon ring resonator (2019)

We present a detailed experimental study of the mitigation of two-photon absorption (TPA) in a silicon micro ring modulator. TPA induced free-carrier absorption results in interesting optoelectronic process in silicon ring resonators. In this work, we study the effect of optical and RF power on the spectral characteristics of a ring modulator. In particular, we report the evolution of optical bistability in the transmission spectrum with free carriers and thermally induced refractive index change.
Long-term geoelectrical monitoring of landslides in natural and engineered slopes (2022)

Abstract Developments in time-lapse electrical resistivity tomography (ERT) technology are transforming our ability to monitor the subsurface due to purpose-built monitoring instruments, advances in automation and modeling, and the resulting improvements in spatial and temporal resolution. We describe the development of a novel ERT-based remote monitoring system called PRIME that integrates new low-power measurement instrumentation with data delivery, automated data processing and image generation, and web-based information delivery. Due to the sensitivity of ERT to hydrologic processes in the near surface, we focus on the application of PRIME for moisture-driven landslide monitoring. Case examples are considered of landslides in engineered and natural slopes, including those impacting geotechnical assets in rail and highways, where slope hydrology is seen to be controlled by lithology, vegetation, fissuring, and drainage structures. We conclude by taking a forward look at emerging developments in ERT monitoring relating to hardware, software and modeling, and applications.
ChemInform Abstract: PERSAEUREOXIDATION VON EN-LACTAMEN, EINE SYNTHESE FUER MAKROCYCLISCHE IMIDE (1971)

Aus den Ketonen (I) werden die Addukte (II) hergestellt und über die Amide (III) zu den Lactamen (IVa)-(IVd) cyclisiert.
The Effect of Modified Floor Reaction Ankle Foot Orthosis on Walking Abilities in Children with Cerebral Palsy: A Case Study (2015)

Objective: This study was designed to evaluate the effectiveness of a modified Floor Reaction Ankle Foot Orthosis (FRAFO) design on gait performance in boy with cerebral palsy. Materials & Methods: In this study, one boy with diplegic cerebral palsy (CP) wore a modified FRAFO bilaterally for six weeks. Immediate effectiveness of the orthosis on improving gait and also following six weeks of gradual orthosis use were recorded. Primary outcome measures were walking speed, cadence and stride length, plus hip, knee and ankle joints range of motion that recorded by VICON motion analysis system. Results: Cadence, stride length and walking speed were all increased when the Boy with CP wore the modified FRAFO. The boy demonstrated a reduction in ankle ROM when using the modified FRAFO. The mean knee joint ROM was increased from 36.8±13.72 degrees when walking with an orthosis at baseline to 43.0±1.10 degrees when walking with an orthosis after six weeks of use. Boy with the modified FRAFO also had decreased hip flexion angle at initial contact and an extension shift during stance phase following 6 weeks of orthosis use compared to when initially donning it. Conclusions : A modified FRAFO can improve gait parameters in children with cerebral palsy.