gebhart/patrepeval huggingface dataset:
GENT-03. EXPRESSION LEVEL OF miRNAs ON CHROMOSOME 14q32.31 REGION CORRELATES WITH TUMOR AGGRESSIVENESS AND SURVIVAL OF GLIOBLASTOMA PATIENTS (2016)

The 54 microRNAs (miRNAs) within the DLK-DIO3 genomic region on chromosome 14q32.31 (cluster 14 miRNAs) are organized into sub-clusters 14A and 14B. These miRNAs are downregulated in glioblastomas and might have a tumor suppressive role. Any association between the expression levels of cluster 14 miRNAs with overall survival (OS) is undetermined. We randomly selected miR-433, belonging to sub-cluster 14A and miR-323a-3p and miR-369-3p, belonging to sub-cluster 14B, and assessed their role in glioblastomas in vitro and in vivo. We also determined the expression level of cluster 14 miRNAs in 27 patients with newly diagnosed glioblastoma, and analyzed the association between their level of expression and OS. Overexpression of miR-323a-3p and miR-369-3p, but not miR-433, in glioblastoma cells inhibited their proliferation and migration in vitro. Mice implanted with glioblastoma cells overexpressing miR323a-3p and miR369-3p, but not miR433, exhibited prolonged survival compared to controls (P = .003). Bioinformatics analysis identified 13 putative target genes of cluster 14 miRNAs, and real-time RT-PCR validated these findings. Pathway analysis of the putative target genes identified neuregulin as the most enriched pathway. The expression level of cluster 14 miRNAs correlated with patients’ OS. The median OS was 8.5 months for patients with low expression levels and 52.7 months for patients with high expression levels (HR = 0.34; 95% CI 0.12-0.59, P= .003). The expression level of cluster 14 miRNAs correlates directly with OS, suggesting a role for this cluster in promoting aggressive behavior of glioblastoma, possibly through ErBb/ neuregulin signaling.
Scale-Transferrable Object Detection (2018)

Scale problem lies in the heart of object detection. In this work, we develop a novel Scale-Transferrable Detection Network (STDN) for detecting multi-scale objects in images. In contrast to previous methods that simply combine object predictions from multiple feature maps from different network depths, the proposed network is equipped with embedded super-resolution layers (named as scale-transfer layer/module in this work) to explicitly explore the interscale consistency nature across multiple detection scales. Scale-transfer module naturally fits the base network with little computational cost. This module is further integrated with a dense convolutional network (DenseNet) to yield a one-stage object detector. We evaluate our proposed architecture on PASCAL VOC 2007 and MS COCO benchmark tasks and STDN obtains significant improvements over the comparable state-of-the-art detection models.
Amyotrophic Lateral Sclerosis in a High Selenium Environment (1977)

During a ten-year period, four cases of amyotrophic lateral sclerosis have been found in a sparsely populated county (population 4,000) in west-central South Dakota. The patients were unrelated male farmer-ranchers between 57 and 66 years of age, living within a 15-km radius of each other. The cases occurred in a region where naturally occurring selenium toxication is endemic in farm animals.
Cushing's syndrome due to ACTH-secreting pheochromocytoma. (2008)

Ectopic secretion of adrenocorticotropic hormone (ACTH) is an infrequent cause of Cushing's syndrome. We report a case of ectopic ACTH syndrome caused by a pheochromocytoma. A 53-year-old female with clinical features of Cushing s syndrome presented with serious recurrent hypertensive crisis. Endocrinological investigation confirmed the diagnosis of ectopic ACTH production and revealed markedly elevated urinary catecholamines leading to the diagnosis of pheochromocytoma. Abdominal computerized tomography (CT) scan showed a 3.5 cm left adrenal mass and a nodular hypertrophic right adrenal gland. Bilateral selective adrenal vein catheterization suggested bilateral pheochromocytoma. After treatment with phenoxybenzamine, bilateral adrenalectomy was performed and resulted in remission of Cushing's syndrome and hypertensive crisis. In addition, this article provides a short guideline for endocrine testing if Cushing's disease or pheochromocytoma is suspected. However, the most important message of this article is to think of them.
Impact of acute hepatic porphyria attack frequency on patient-reported outcomes: results from the Porphyria Worldwide Patient Experience Research (POWER) study (2023)

Introduction: Acute hepatic porphyria (AHP), a group of rare genetic diseases, is characterized by neurovisceral attacks. Objective: This study evaluated its impact in patients with sporadic or recurrent attacks. Methods: Adult patients having &gt;1 attack within the past two years or receiving prophylactic treatment were recruited from the United States, Italy, Spain, Australia, Mexico, and Brazil for an online survey. Patients taking givosiran were excluded. Differences between patients with sporadic attacks (annualized attack rate [AAR], &lt;6 within past two years) and recurrent attacks (AAR, ≥6) were evaluated. Attacks included those leading to hospitalization, emergency room, outpatient doctor, or self-management. Outcomes were assessed with Generalized Anxiety Disorder-7 (GAD-7), Patient Health Questionnaire (PHQ-8) and burden of chronic symptoms. Results: Of the 92 patients who completed the survey, 60% reported sporadic attacks and 40% recurrent attacks. Most patients were female (sporadic 92.7%; recurrent 86.5%), and the most frequent diagnosis was acute intermittent porphyria (sporadic 83.6%; recurrent 59.4%). Most patients in the sporadic (52.7%) and recurrent (67.6%) groups reported a PHQ-8 score indicating moderate to severe depression; 43.6% in the sporadic and 56.8% of recurrent groups reported a GAD-7 score indicating moderate to severe anxiety. Pain was one of the most burdensome chronic symptoms in the sporadic (50.9%) and recurrent (59.5%) groups. Most patients reported muscle weakness as a top three symptom that limited their daily activities (sporadic 83.3%; recurrent 90.6%). Conclusion: While disease burden appeared greater for AHP patients experiencing recurrent attacks, both sporadic and recurrent group patients experienced a substantial impact on physical, mental, and emotional quality of life.
Compiler transformations for high-performance computing (1994)

In the last three decades a large number of compiler transformations for optimizing programs have been implemented. Most optimizations for uniprocessors reduce the number of instructions executed by the program using transformations based on the analysis of scalar quantities and data-flow techniques. In contrast, optimizations for high-performance superscalar, vector, and parallel processors maximize parallelism and memory locality with transformations that rely on tracking the properties of arrays using loop dependence analysis. This survey is a comprehensive overview of the important high-level program restructuring techniques for imperative languages, such as C and Fortran. Transformations for both sequential and various types of parallel architectures are covered in depth. We describe the purpose of each transformation, explain how to determine if it is legal, and give an example of its application. Programmers wishing to enhance the performance of their code can use this survey to improve their understanding of the optimizations that compilers can perform, or as a reference for techniques to be applied manually. Students can obtain an overview of optimizing compiler technology. Compiler writers can use this survey as a reference for most of the important optimizations developed to date, and as bibliographic reference for the details of each optimization. Readers are expected to be familiar with modern computer architecture and basic program compilation techniques.
Reduced Tumor Size of Untreated Papillary Thyroid Carcinoma After Immune Checkpoint Inhibitor–Induced Thyroiditis (2023)

Further research to assess the immunologic mechanism underlying this association is warranted to potentially develop improved immunotherapy for PTC.
Association of Posttreatment Lymphopenia and Elevated Neutrophil-to-Lymphocyte Ratio With Poor Clinical Outcomes in Patients With Human Papillomavirus–Negative Oropharyngeal Cancers (2019)

Lymphopenia and NLR as early as 3 months after treatment start may serve as biomarkers of clinical outcomes in patients with HPV-negative OPC. These patients may benefit from adjuvant treatment intensification or closer surveillance.
Acoustic and viscoelastic characterization of hydrogel scaffolds to optimize preparation parameters for tissue engineering applications (2022)

Cell growth and differentiation rely upon both biochemical and mechanical cues. Though the focus has historically been biochemical, there is an increasing interest on the mechanical properties of scaffold materials within the field of tissue engineering. When the mechanical properties of a scaffold material more closely match with those of the intended native tissue, the functionality of the tissue scaffold is significantly enhanced. This study explores how an acoustic and viscoelastic characterization of a popular hydrogel, gelatin methacrylate (GelMA), can be used to inform the synthesis and fabrication parameters for a variety of tissue engineering applications. GelMA scaffolds exhibiting a range of mechanical properties were produced by varying the concentration of GelMA and by varying the curing time of the scaffolds. Pulse-echo ultrasound techniques were used to determine the sound speed and attenuation, revealing a significant dependence on the GelMA concentration. Compression tests were also performed, showing an increased stiffness with certain preparation parameters. Finally, atomic force microscopy experiments were used to obtain the storage and loss moduli of the hydrogels, revealing an increase in hydrogel stiffness at short time scales for both the GelMA concentration and curing time.
Interfacial Energy in Phase‐Separated Glasses from Emulsion Rheology (2005)

Classical theories of emulsion rheology yield information on the deformation of a liquid drop dispersed into another liquid matrix phase. By connecting the deformation and relaxation, respectively, and the capillary number of the dispersed phase, interfacial energy can be estimated. This was applied to demixing borosilicate and lead borate glasses, which are known to exhibit significant form anisotropy after elongation. Interfacial energies in these two systems were calculated based on graphical data of prior isothermal elongation experiments. The method is discussed in terms of experimental difficulties. It might provide an alternative way to overcome the obvious lack of information on interfacial energies in glasses.
Valsartan provides effective antihypertensive response in older patients: An integrated analysis (2000)

Population studies have shown a greater prevalence of cardiovascular (CV) morbidity and mortality in Asian Indian compared to white subjects, but longitudinal data in essential hypertension are limited. We followed-up 528 white and 106 Asian Indian subjects who underwent 24 hour intraarterial ambulatory blood pressure (BP) monitoring a mean of 10 years earlier. Events consisted of 31 non-CV deaths, 26 coronary deaths, 7 cerebrovascular deaths, 46 myocardial infarctions, 20 strokes and 18 revascularisations. At baseline, Asian Indians were younger (469 vs 5211 yrs); p0.001), had a higher prevalence of diabetes (17% vs 5%; p0.001), lower cholesterol (5.61.1 vs 6.01.2mmol/l; p0.001) a trend towards lower 24 hour systolic BP (15420 vs 15722mmHg) and a similar smoking history compared to whites, respectively. Event rates are listed below: Age (p0.001), sex (p0.002), smoking (p0.05), previous CV disease (p0.001), 24 hour systolic BP (p0.006) and race (Asian Indians: whites hazard ratio 1.79; p0.008) were independent predictors of events. The increased CV risk in Asian Indians was due to an excess of coronary events.
Synthesis and Structure−Activity Relationships of Bafilomycin A1 Derivatives as Inhibitors of Vacuolar H+-ATPase (1998)

The macrolide antibiotic bafilomycin A1 is a highly potent and selective inhibitor of all the vacuolar ATPases (V-ATPases). With the aim of obtaining novel analogues specific for the osteoclast subclass of vacuolar ATPase, 31 derivatives of bafilomycin A1 were synthesized and tested for their ability to inhibit differentially the V-ATPase-driven proton transport in membrane vesicles derived from chicken osteoclasts (cOc) and bovine chromaffin granules (bCG). Although none of the new analogues were more potent than the parent compound, the obtained data provided a significant amount of information about the structural requirements for the inhibitory activity of bafilomycin A1. The different effects of a few analogues on the two enzymes could also suggest the possibility of a selective modulation of the V-ATPases in different tissues.
Biosynthetic production of curcuminoids (2015)

Curcuminoids are natural phenylpropanoids from plants that have been reported as potential cancer-fighting drugs. Nevertheless, these compounds present a poor bioavailability. Cellular uptake is low and curcuminoids are quickly metabolized once inside the cell, requiring repetitive oral doses to achieve an effective concentration for therapeutic activity [1]. Herein, we report an engineered artificial pathway for the production of curcuminoids in Escherichia coli. Arabidopsis thaliana 4-coumaroyl-CoA ligase and Curcuma longa diketide-CoA synthase (DCS) and curcumin synthase (CURS1) were used and 188 µM (70 mg/L) of curcumin was obtained from ferulic acid [2]. Bisdemethoxycurcumin and demethoxycurcumin were also produced, but in lower concentrations, by feeding p-coumaric acid or a mixture of p-coumaric acid and ferulic acid, respectively. Additionally, curcuminoids were produced from tyrosine through the caffeic acid pathway. To produce caffeic acid, tyrosine ammonia lyase from Rhodotorula glutinis and 4-coumarate 3-hydroxylase from Saccharothrix espanaensis were used [3]. Caffeoyl-CoA 3-O-methyl-transferase from Medicago sativa was used to convert caffeoyl-CoA to feruloyl-CoA. Using caffeic acid, p-coumaric acid or tyrosine as a substrate, 3.9, 0.3, and 0.2 µM of curcumin were produced, respectively. This is the first report on the use of DCS and CURS1 in vivo to produce curcuminoids. In addition, curcumin, the most studied curcuminoid for therapeutic purposes and considered in many studies as the most potent and active, was produced by feeding tyrosine using a pathway involving caffeic acid. We anticipate that by using a tyrosine overproducing strain, curcumin can be produced in E. coli without the need of adding expensive precursors to the medium, thus decreasing the production cost. Therefore, this alternative pathway represents a step forward in the heterologous production of curcumin using E. coli. Aiming at greater production titers and yields, the construction of this pathway in another model organism such as Saccharomyces cerevisiae is being considered.
3D ROC analysis for detection software used in water monitoring (2005)

Under the U.S. Army sponsored Joint Service Agent Water Monitor (JSAWM) program, developing hand-held assays using tickets for chemical/biological agent detection has been of major interest. One of keys to success is to develop detection algorithms that not only can effectively detect the presence of various agents, but also can quantify the detected agents. This paper presents a recent development of detection software that can perform 3-dimensional (3D) receiver operating characteristics (ROC) analysis which is based on quantified agent concentration. The ROC curves have been widely used in communications, signal processing and medical communities to evaluate the effectiveness of a detection technique. It generally formulates a signal detection problem as a binary composite hypothesis testing problem with the null hypothesis and the alternative hypothesis represents the case of no signal and the case of signal presence respectively. The ROC curve is then plotted based on the detection probability (power) P<sub>D</sub> versus the false alarm probability, P<sub>F</sub>. Unfortunately, such a two-dimensional (2D) (P<sub>D</sub>,P<sub>F</sub>)-based ROC curve does not factor in the concentration detected in an agent signal which is a crucial parameter in chemical/biological agent detection. The proposed 3D ROC analysis is developed from such a need. It includes an additional parameter, referred to as threshold <i>t</i>, which is used to threshold the detected agent signal concentration. Consequently, a different value of <i>t</i> results in a different 2D ROC curve. In order to take into account the thresholding factor <i>t</i>, a 3D ROC curve is derived and plotted based on three parameters, (P<sub>D</sub>,P<sub>F</sub>,<i>t</i>). As a result of the 3D ROC curve, three 2D ROC curves can be also derived. One is the conventional 2D (P<sub>D</sub>,P<sub>F</sub>)-ROC curve. Another is a 2D (P<sub>D</sub>,<i>t</i>)-ROC curve which describes the relationship between P<sub>D</sub> and the threshold value <i>t</i>. A third one is a 2D (P<sub>F</sub>,<i>t</i>)-ROC curve which shows the effect of the threshold value <i>t</i> on P<sub>F</sub>. The utility of the proposed 3D ROC analysis will be demonstrated by the detection software developed by the UMBC for the tickets used in HHA for water monitoring.
Stereospecific Formal Total Synthesis of Ecteinascidin 743 (2006)

A new strategy was designed for the construction of the pentacyclic ring system of ecteinascidin 743. Key features include highly concise routes to the enantiopure, configurationally matched subunit 1, a novel vinylogous Pictet–Spengler cyclization to 2, and a stereospecific epoxidation and regioselective reduction sequence of the C3C4 enamide to secure 3. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z503983_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Synchronising C/C++ and POWER (2012)

Shared memory concurrency relies on synchronisation primitives: compare-and-swap, load-reserve/store-conditional (aka LL/SC), language-level mutexes, and so on. In a sequentially consistent setting, or even in the TSO setting of x86 and Sparc, these have well-understood semantics. But in the very relaxed settings of IBM®, POWER®, ARM, or C/C++, it remains surprisingly unclear exactly what the programmer can depend on.
Binding of Cholecystokinin‐8 (CCK‐8) Peptide Derivatives to CCKAand CCKBReceptors (1994)

The structural requirements for the selective binding of cholecystokinin-8 (CCK-8)-related peptides to peripheral (CCKA) receptors are not sufficiently understood. In this study, the interaction of a series of newly shortened analogues of CCK-8 with both receptor subtypes was analyzed by displacement studies using [3H]-CCK-8 and 125I-Bolton-Hunter (BH)-CCK-8 as radioligands. The pentapeptide derivative of CCK-8, succinyl-Tyr (SO3H)-Met-Gly-Trp-Met-phenethylamide, was found to bind selectively with high affinity to the CCKA receptor. The replacement of Met28 and/or Met31 by norleucine and of L-Trp30 by its D-analogue had no significant effect on the binding properties of the peptide. Further C-terminal shortening resulted in a drastic loss of affinity and selectivity of the CCK receptor binding.
<title>FELSTRON: an FEL oscillator power source for linear colliders</title> (1992)

Electrostatic free electron lasers (FELs) operating in the oscillator mode have been demonstrated to be extremely efficient sources of coherent electromagnetic (laser) radiation. Output wavelengths between tens of microns and a few centimeters are achievable. The average power of these devices can be quite large (100s of KW). Linear colliders require high peak power as well as high average power. By storing the laser energy of an electrostatic FEL oscillator in a resonant cavity, and then employing a cavity dump, extremely high peak output power is obtainable. The high efficiency, accessible wavelength range, large average power and high peak power make electrostatic accelerator FELs excellent candidates for linear collider power sources.
ChemInform Abstract: Synthesis of Substituted Benzamides as Antiinflammatory Agents that Inhibit Preferentially Cyclooxygenase 1 but Do Not Cause Gastric Damage. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Highlights of the Annual Meeting of the Italian Association for Cell Cultures (AICC): new drug delivery strategies and technological platforms for diagnosis and therapy of tumors (Part I) (2008)

The application of computational analysis to biochemistry and molecular biology techniques has allowed the design of advanced technological platforms such as DNA microarrays, proteomic analysis and tissue microarrays. These are useful in the diagnosis of tumors and in driving the choice of opportune therapeutic options. The use of target-based agents requires the determination of the molecular features of the tumors. During the AICC meeting four new advanced technological platforms were analyzed: DNA microarrays, ProtoArrays, tissue microarrays and proteomic analysis with differential in-gel electrophoresis (DIGE) and matrix-associated laser desorption ionization-time of flight (MALDI-TOF). The use of DNA microarray in the study of neo-angiogenic components in tumor tissues was described and the ex vivo analysis in humans of circulating endothelial cells was proposed. The role of both genomic and pharmacogenomic profiles in the diagnosis and prediction of response to therapy and toxicity of both breast and colorectal cancer was described. A developmental model for the optimization of zoledronic acid (ZOL) antitumor activity based on either nanotechnological modification or molecular target fishing with DNA microarrays was discussed. The interdisciplinary network between pharmacologists, cellular and molecular biologists, biochemists and translational and clinical oncologists was encouraged and approved during the meeting in order to improve the efficacy of antitumor strategies.
In vitro additive effects of dalbavancin and rifampicin against biofilm of Staphylococcus aureus (2021)

Dalbavancin is a novel glycopeptide antibiotic approved for the treatment of acute bacterial skin and skin structure infections (ABSSSIs). It is characterized by a potent activity against numerous Gram-positive pathogens, a long elimination half-life and a favorable safety profile. Most recently, its application for the treatment of periprosthetic joint infections (PJIs) was introduced. The aim of this study was to proof our hypothesis, that dalbavancin shows superior efficacy against staphylococcal biofilms on polyethylene (PE) disk devices compared with vancomycin and additive behavior in combination with rifampicin. Staphylococcus aureus biofilms were formed on PE disk devices for 96 h and subsequently treated with dalbavancin, vancomycin, rifampicin and dalbavancin-rifampicin combination at different concentrations. Quantification of antibacterial activity was determined by counting colony forming units (CFU/ml) after sonification of the PE, serial dilution of the bacterial suspension and plating on agar-plates. Biofilms were additionally life/dead-stained and visualized using fluorescence microscopy. Dalbavancin presented superior anti-biofilm activity compared to vancomycin. Additive effects of the combination dalbavancin and rifampicin were registered. Dalbavancin combined with rifampicin presents promising anti-biofilm activity characteristics in vitro. Further in vivo studies are necessary to establish recommendations for the general use of dalbavancin in the treatment of PJIs.