gebhart/patrepeval huggingface dataset:
Car pooling on the Net: Performance and Implications (1999)

Small packets dominate Internet traffic patterns today. The overhead due to queuing, processing, routing, differential treatment, and delivery is the same irrespective of the size of the packet. Hence, small packets impose a relatively higher overhead on the network. The domination of small packet traffic is expected to get only worse with the ever increasing web applications and the introduction of new applications such as Voice over IP. To mitigate the impact of small packets, we suggest a novel approach of combining multiple small packets going towards the same destination; akin to car (packet) pooling. We report the results of extensive simulation studies to determine the performance benefits of packet pooling on web servers. In addition, we analyze some of the side-effects of aggregation and evaluate the impact of aggregation on TCP and suggest corrective measures. We also evaluate the impact of aggregating non-responsive flows (small packet UDP traffic) on TCP and we discover that aggregation can be used to lessen the impact of non-responsive flows on TCP up to certain levels of offered UDP load. Furthermore, we can use these performance results as a guide to determine the level of aggregation and incentives required for flows to be subject to aggregation so as to improve the overall network performance.
RANITIDINE, CIMETIDINE, AND THE CYCLOSPORINE-TREATED RECIPIENT (1986)

Jarowenki, Mark V.; Van Buren, Charles T.; Kramer, William G.; Lorber, Marc I.; Flechner, Stuart M.; Kahan, Barry D. Author Information
Dopamine D 2 ‐receptor activation elicits akinesia, rigidity, catalepsy, and tremor in mice expressing hypersensitive α4 nicotinic receptors via a cholinergic‐dependent mechanism (2009)

Recent studies suggest that high-affinity neuronal nicotinic acetylcholine receptors (nAChRs) containing alpha4 and beta2 subunits (alpha4beta2*) functionally interact with G-protein-coupled dopamine (DA) D(2) receptors in basal ganglia. We hypothesized that if a functional interaction between these receptors exists, then mice expressing an M2 point mutation (Leu9'Ala) rendering alpha4 nAChRs hypersensitive to ACh may exhibit altered sensitivity to a D(2)-receptor agonist. When challenged with the D(2)R agonist, quinpirole (0.5-10 mg/kg), Leu9'Ala mice, but not wild-type (WT) littermates, developed severe, reversible motor impairment characterized by rigidity, catalepsy, akinesia, and tremor. While striatal DA tissue content, baseline release, and quinpirole-induced DA depletion did not differ between Leu9'Ala and WT mice, quinpirole dramatically increased activity of cholinergic striatal interneurons only in mutant animals, as measured by increased c-Fos expression in choline acetyltransferase (ChAT)-positive interneurons. Highlighting the importance of the cholinergic system in this mouse model, inhibiting the effects of ACh by blocking muscarinic receptors, or by selectively activating hypersensitive nAChRs with nicotine, rescued motor symptoms. This novel mouse model mimics the imbalance between striatal DA/ACh function associated with severe motor impairment in disorders such as Parkinson's disease, and the data suggest that a D(2)R-alpha4*-nAChR functional interaction regulates cholinergic interneuron activity.
Topical intranasal lidocaine is not a sphenopalatine ganglion block (2020)

There is renewed interest in the central role of the sphenopalatine ganglion (SPG) in cerebrovascular autonomic physiology and the pathophysiology of different primary and secondary headache disorders. There are diverse neural structures (parasympathetic, sympathetic and trigeminal sensory) that convene into the SPG which is located within the pterygopalatine fossa (PPF). This makes the PPF an attractive target to neuromodulatory interventions of these different neural structures. Some experts advocate for the nasal application of local anesthetics as an effective route for SPG block with the belief that the local anesthetic can freely access the PPF. It is time to challenge this historical concept from the early 1900s. In this daring discourse, I will review anatomical studies, CT and MRI reports to debunk this old myth. Will provide anatomical evidence to explain that all these assumptions are untrue and the local anesthetic has to magically 'travel' a distance of 4-12 mm of adipose and connective tissue to reach the SPG in sufficient concentration and volume to effectively induce SPG blockade. Future research should focus on assessing a clinical biomarker to confirm SPG blockade. It could be regional cerebral blood flow or lacrimal gland secretion.
MiR-140 is co-expressed withWwp2-Ctranscript and activated by Sox9 to targetSp1in maintaining the chondrocyte proliferation (2011)

MiR-140 is a microRNA specially involved in chondrogenesis and osteoarthritis pathogenesis. However, its transcriptional regulation and target genes in cartilage development are not fully understood. Here we detected that miR-140 was uniquely expressed in chondrocyte and suppressed by Wnt/β-catenin signalling. The miR-140 primary transcript was an intron-retained RNA co-expressed with Wwp2-C isoform, which was directly induced by Sox9 through binding to the intron 10 of Wwp2 gene. Knockdown of miR-140 in limb bud micromass cultures resulted in arrest of chondrogenic proliferation. Sp1, the activator of the cell cycle regulator p15(INK4b), was identified as a target of miR-140 in maintaining the chondrocyte proliferation. Collectively, our findings expand our understanding of the transcriptional regulation and the chondrogenic role of miR-140 in chondrogenesis.
The IBUS Process – Lignocellulosic Bioethanol Close to a Commercial Reality (2008)

Abstract Integrated Biomass Utilization System (IBUS) is a new process for converting lignocellulosic waste biomass to bioethanol. Inbicon A/S has developed the IBUS process in a large‐scale process development unit. This plant features new continuous and energy‐efficient technology developed for pretreatment and liquefaction of lignocellulosic biomass and has now been operated and optimized for four years with promising results. In the IBUS process, biomass is converted using steam and enzymes only. The process is energy efficient due to very high dry matter content in all process steps and by integration with a power plant. Cellulose is converted to bioethanol and lignin to a high‐quality solid biofuel which supply the process energy as well as a surplus of heat and power. Hemicellulose is used as feed molasses but in the future it could also be used for additional ethanol production or other valuable products. Feasibility studies of the IBUS process show that the production price for lignocellulosic bioethanol is close to the world market price for fuel ethanol. There is still room for optimization – and lignocellulosic bioethanol is most likely a commercial alternative to fossil transport fuels before 2012.
The generalized distributive law (2000)

We discuss a general message passing algorithm, which we call the generalized distributive law (GDL). The GDL is a synthesis of the work of many authors in information theory, digital communications, signal processing, statistics, and artificial intelligence. It includes as special cases the Baum-Welch algorithm, the fast Fourier transform (FFT) on any finite Abelian group, the Gallager-Tanner-Wiberg decoding algorithm, Viterbi's algorithm, the BCJR algorithm, Pearl's "belief propagation" algorithm, the Shafer-Shenoy probability propagation algorithm, and the turbo decoding algorithm. Although this algorithm is guaranteed to give exact answers only in certain cases (the "junction tree" condition), unfortunately not including the cases of GTW with cycles or turbo decoding, there is much experimental evidence, and a few theorems, suggesting that it often works approximately even when it is not supposed to.
High-Redshift Quasars as Probes of Galaxy and Cluster Formation (1999)

Quasars at large redshifts provide a powerful probe of structure formation in the early universe. Several arguments suggest that the formation of ellipticals and massive bulges may have involved an early quasar phase. At very large redshifts, such structures are likely to be found at the highest peaks of the density field, and would thus be highly biased tracers: the earliest (massive) galaxy formation may have occurred in the cores of future rich clusters. Preliminary results from our search for clustered protogalaxies around quasars at z &gt; 4 support this idea. Quasars at even larger redshifts may be an important contributor to the reionisation of the universe, and signposts of the earliest galaxy and cluster formation.
The V-Way Cache: Demand Based Associativity via Global Replacement (2005)

As processor speeds increase and memory latency becomes more critical, intelligent design and management of secondary caches becomes increasingly important. The efficiency of current set-associative caches is reduced because programs exhibit a non-uniform distribution of memory accesses across different cache sets. We propose a technique to vary the associativity of a cache on a per-set basis in response to the demands of the program. By increasing the number of tag-store entries relative to the number of data lines, we achieve the performance benefit of global replacement while maintaining the constant hit latency of a set-associative cache. The proposed variable-way, or V-Way, set-associative cache achieves an average miss rate reduction of 13% on sixteen benchmarks from the SPEC CPU2000 suite. This translates into an average IPC improvement of 8%.
Lower urinary tract symptoms/benign prostatic hypertrophy and vascular function: Role of the nitric oxide–phosphodiesterase type 5–cyclic guanosine 3′,5′‐monophosphate pathway (2017)

It is well known that there is an association of lower urinary tract symptoms/benign prostatic hypertrophy with cardiovascular disease, suggesting that lower urinary tract symptoms/benign prostatic hypertrophy is a risk factor for cardiovascular events. Vascular function, including endothelial function and vascular smooth muscle function, is involved in the pathogenesis, maintenance and development of atherosclerosis, leading to cardiovascular events. Vascular dysfunction per se should also contribute to lower urinary tract symptoms/benign prostatic hypertrophy. Both lower urinary tract symptoms/benign prostatic hypertrophy and vascular dysfunction have cardiovascular risk factors, such as hypertension, dyslipidemia, diabetes mellitus, aging, obesity and smoking. Inactivation of the phosphodiesterase type 5-cyclic guanosine 3',5'-monophosphate-nitric oxide pathway causes lower urinary tract symptoms/benign prostatic hypertrophy through an enhancement of sympathetic nervous activity, endothelial dysfunction, increase in Rho-associated kinase activity and vasoconstriction, and decrease in blood flow of pelvic viscera. Both endogenous nitric oxide and exogenous nitric oxide act as vasodilators on vascular smooth muscle cells through an increase in the content of cyclic guanosine 3',5'-monophosphate, which is inactivated by phosphodiesterase type 5. In a clinical setting, phosphodiesterase type 5 inhibitors are widely used in patients with lower urinary tract symptoms/benign prostatic hypertrophy. Phosphodiesterase type 5 inhibitors might have beneficial effects on vascular function through not only inhibition of cyclic guanosine 3',5'-monophosphate degradation, but also increases in testosterone levels and nitric oxide bioavailability, increase in the number and improvement of the function of endothelial progenitor cells, and decrease in insulin resistance. In the present review, the relationships between lower urinary tract symptoms/benign prostatic hypertrophy, the phosphodiesterase type 5-nitric oxide-cyclic guanosine 3',5'-monophosphate pathway, vascular function and cardiovascular outcomes are examined.
Beyond Equal-Length Snippets: How Long is Sufficient to Recognize an Audio Scene? (2018)

Due to the variability in characteristics of audio scenes, some scenes can naturally be recognized earlier than others. In this work, rather than using equal-length snippets for all scene categories, as is common in the literature, we study to which temporal extent an audio scene can be reliably recognized given state-of-the-art models. Moreover, as model fusion with deep network ensemble is prevalent in audio scene classification, we further study whether, and if so, when model fusion is necessary for this task. To achieve these goals, we employ two single-network systems relying on a convolutional neural network and a recurrent neural network for classification as well as early fusion and late fusion of these networks. Experimental results on the LITIS-Rouen dataset show that some scenes can be reliably recognized with a few seconds while other scenes require significantly longer durations. In addition, model fusion is shown to be the most beneficial when the signal length is short.
PLURALISMO JURÍDICO E A CONSTRUÇÃO DO PROTOCOLO DE CONSULTA: A EXPERIÊNCIA DA FEDERAÇÃO QUILOMBOLA DE SANTARÉM, PARÁ (2018)

Este artigo apresenta o resultado da pesquisa participante desenvolvida junto as comunidades quilombolas em parceria com a Federacao das Organizacoes Quilombolas de Santarem (FOQS). A pesquisa tratou da construcao e uso do Protocolo de Consulta elaborado pela FOQS em 2016 a partir de metodo qualitativo de pesquisa tomando como objeto as referencias bibliograficas sobre o tema, textos de lei, decisoes judiciais e as manifestacoes publicas realizadas pela FOQS durante os anos de 2016 e 2017 em face do licenciamento ambiental de portos de interesse da empresa EMBRAPS no Lago do Maica, municipio de Santarem-PA.
Montelukast in hospitalized patients diagnosed with COVID-19 (2021)

Hospitalized COVID-19 patients treated with montelukast had fewer events of clinical deterioration, indicating that this treatment may have clinical activity. While this retrospective study highlights a potential pathway for COVID-19 treatment, this hypothesis requires further study by prospective studies.
Purification and properties of an oestrogen-stimulated mouse uterine glycoprotein (approx. 70 kDa) (1986)

An oestrogen-induced secretory protein from mouse uterine luminal fluid was purified by CM-Affi-Gel Blue chromatography and reverse-phase h.p.l.c. This protein has an apparent molecular mass of approx. 70 kDa both by SDS/polyacrylamide-gel electrophoresis (with or without 2-mercaptoethanol) and by gel-filtration column chromatography, indicating that it exists as a single-chain polypeptide. Further analysis of the protein revealed that it is highly basic (pI greater than or equal to 10) and is a glycoprotein. The N-terminus appears to be blocked to Edman degradation. The partial amino acid sequence of a fragment was obtained by cleavage with CNBr; no sequence homology was apparent between the analysed fragment and other known sequences. The incorporation of [35S]methionine into uterine proteins in vitro revealed that oestrogen treatment of immature mice stimulates both synthesis and secretion of the 70 kDa protein. An enzyme-linked immunosorbent assay with polyclonal antibody was used to determine the tissue distribution of the protein. Tissues such as lung, brain, spleen, muscle, intestine, liver, kidney and ovary of oestrogen-treated mice did not have detectable amounts of the 70 kDa protein. Immunoreactivity was present in uterine and vaginal tissues from oestrogen-treated animals. The 70 kDa protein was not induced by testosterone or progesterone. Although the function of this protein is unknown, it is useful as a marker for the study of oestrogen action in the mammalian uterus as well as regulation of gene expression at the molecular level.
Efficient Online WiFi Delivery of Layered-Coding Media Using Inter-layer Network Coding (2011)

A primary challenge in multi casting video in a wireless LAN to multiple clients is to deal with the client diversity -- clients may have different channel characteristics and hence receive different numbers of transmissions from the AP. A promising approach to overcome this problem is to combine multi-resolution (layered) video coding with interlayer network coding. The fundamental challenge in such an approach is to determine the strategy of coding the packets across different layers that maximizes the number of decoded layers at all clients. This paper makes three contributions. (1) We first show that even for one client, the previously proposed canonical triangular scheme for inter-layer network coding can perform poorly. We show how to enhance the triangular scheme by incorporating the estimated target number of layers which significantly improves its effectiveness. (2) We show that such an enhanced triangular scheme still performs poorly for multiple clients with diverse channel characteristics, which motivates the need for searching for the optimal coding strategy. The naive way of searching for the optimal strategy is computationally prohibitive. We present several optimizations that drastically reduce the complexity of exhaustively searching for the optimal strategy, making it feasible in real time. (3) Finally, we design and evaluate an on line video delivery scheme, Percy, to be deployed at a proxy behind the AP of a wireless LAN. Our simulation results show that Percy outperforms the previous inter-layer coding heuristic by up to 22-80% with varying numbers of clients.
Smooth, an hnRNP-L Homolog, Might Decrease Mitochondrial Metabolism by Post-Transcriptional Regulation of Isocitrate Dehydrogenase (Idh) and Other Metabolic Genes in the Sub-Acute Phase of Traumatic Brain Injury (2017)

Traumatic brain injury (TBI) can cause persistent pathological alteration of neurons. This may lead to cognitive dysfunction, depression and increased susceptibility to life threatening diseases, such as epilepsy and Alzheimer's disease. To investigate the underlying genetic and molecular basis of TBI, we subjected <i>w</i><sup>1118</sup><i>Drosophila melanogaster</i> to mild closed head trauma and found that mitochondrial activity is reduced in the brains of these flies 24 h after inflicting trauma. To determine the transcriptomic changes after mild TBI, we collected fly heads 24 h after inflicting trauma, and performed RNA-seq analyses. Classification of alternative splicing changes showed selective retention (RI) of long introns (>81 bps), with a mean size of ~3,000 nucleotides. Some of the genes containing RI showed a significant reduction in transcript abundance and are involved in mitochondrial metabolism such as Isocitrate dehydrogenase (Idh), which makes α-KG, a co-factor needed for both DNA and histone demethylase enzymes. The long introns are enriched in CA-rich motifs known to bind to Smooth (Sm), a heterogeneous nuclear ribonucleoprotein L (hnRNP-L) class of splicing factor, which has been shown to interact with the H3K36 histone methyltransferase, SET2, and to be involved in intron retention in human cells. H3K36me3 is a histone mark that demarcates exons in genes by interacting with the mRNA splicing machinery. Mutating sm (<i>sm</i><sup>4</sup>/Df) resulted in loss of both basal and induced levels of RI in many of the same long-intron containing genes. Reducing the levels of Kdm4A, the H3K36me3 histone demethylase, also resulted in loss of basal levels of RI in many of the same long-intron containing genes. Chromatin immunoprecipitation followed by deep sequencing (ChIP-seq) for H3K36me3 revealed increased levels of this histone modification in retained introns post-trauma at CA-rich motifs. Based on these results, we propose a model in which TBI temporarily decreases mitochondrial activity in the brain 24 h after inflicting trauma, which decreases α-KG levels, and increases H3K36me3 levels and intron retention of long introns by decreasing Kdm4A activity. The consequent reduction in mature mRNA levels in metabolism genes, such as Idh, further reduces α-KG levels in a negative feedback loop. We further propose that decreasing metabolism after TBI in such a manner is a protective mechanism that gives the brain time to repair cellular damage induced by TBI.
Outcome of patient with high-risk chronic myelomonocytic leukemia, treated with decitabine prior to transformation to acute myeloid leukemia: A case report (2018)

The present study describes a patient with high-risk chronic myelomonocytic leukemia (CMML), for whom decitabine therapy achieved partial remission, prior to a sudden transformation to acute myeloid leukemia (AML) and an inferior outcome. The 53-year-old male reported easily bruising for 5 months. Examination indicated a diagnosis of CMML. Chromosome analysis identified a 48, XY, +8, +21 karyotype, classifying the patient as high-risk, according to a clinical/molecular CPSS (CPSS-Mol) model. Gene sequencing detected a mutation in DNA methyltransferase 3α, which is relatively rarely identified in CMML and has recently been reported to have an independent prognostic impact on overall survival time. Partial remission was achieved with decitabine treatment, and hematologic improvement was observed subsequent to 2 cycles of treatment. However, a sudden transformation to AML led to fatality of the patient. This case suggests that decitabine may be an effective therapeutic for high-risk CMML; however, the response may be temporary, and the ultimate outcome may be extremely poor. Therefore, novel treatment strategies of CMML, including combination therapies with decitabine, or targeted drugs, including Janus kinase inhibitors or granulocyte-macrophage colony stimulating factor monoclonal antibodies, require investigation.
Some Observations on Parallel Algorithms for Fast Exponentiation in $\operatorname{GF}(2^n)$ (1990)

A normal basis representation of $\operatorname{GF}(2^{n})$ allows squaring to be accomplished by a cyclic shift. Algorithms for multiplication in $\operatorname{GF}(2^{n})$ using a normal basis have been studied by several researchers. In this paper, algorithms for performing exponentiation in $\operatorname{GF}(2^{n})$ using a normal basis, and how they can be speeded up by using parallelization, are investigated.
Clobetasol Propionate Cream Versus Halcinonide Cream in Psoriasis (1986)

Peer Reviewed
Comparison of Surface Flashover Characteristics of Rod and Rib Type Post Insulator for Extra-High Voltage Superconducting Fault Current Limiter (2017)

One of the most important insulating components for developing a 154 kV superconducting fault current limiter (SFCL) is post insulator, which supports 154-kV SFCL modules in a cryostat. In order to design an optimum post insulator, the top priority is to determine the creepage distance of post insulator. In our previous research, surface flashover voltages along smooth glass fiber reinforced polymer (GFRP) rods immersed in liquid nitrogen (LN2) were experimentally investigated. To reduce the cryostat volume, ribbed post insulators with increased creepage path were then considered. However, due to difficulties with producing ribbed GFRP post insulators, ribbed specimens were made of polytetrafluoroethylene instead. Four kinds of test specimens were prepared to determine the position and the number of ribs attached to the surface. From the experimental results, it was found that the ribbed insulator has shown better insulation performance in LN2 and number of ribs could affect the surface flashover voltage of post insulator. Consequently, ribbed model for 154-kV SFCL post insulator was designed and successfully tested. Finally, real 154-kV SFCL system with newly designed ribbed post insulator was installed and Basic Impulse Level (BIL) test and ac required withstand voltage were successfully carried out.