gebhart/patrepeval huggingface dataset:
N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-ethoxybenzamide (2010)

In the title compound, C(17)H(13)F(3)N(2)O(2), the two aromatic rings are essentially coplanar, forming a dihedral angle of 2.78 (12)°. The non-H atoms of the eth-oxy group are coplanar with the attached ring [maximum deviation = 0.271 (3) Å]. An intra-molecular N-H⋯O hydrogen bond occurs. In the crystal structure, mol-ecules are linked by inter-molecular C-H⋯N and C-H⋯F hydrogen bonds.
Comparison of three scoring methods using the FDA-approved 22C3 immunohistochemistry assay to evaluate PD-L1 expression in breast cancer and their association with clinicopathologic factors (2020)

Our findings indicate that the three scoring methods with a 1% cutoff are different in their sensitivity for PD-L1 expression and their associations with clinicopathologic factors. Scoring by TCIC is the most sensitive way to identify PD-L1-positive breast cancer by immunohistochemistry. As a prognostic marker, our study suggests that PD-L1 is associated with worse clinical outcome, most often shown by the IC score; however, the other scores may also have clinical implications in some subgroups. Large clinical trials are needed to test the similarities and differences of these scoring methods for their predictive values in anti-PD-1/PD-L1 therapy.
An Incremental Knowledge Acquisition Method for Improving Duplicate Invoices Detection (2009)

Duplicate records are a major problem and duplicate invoices are a specific example of this. The detection of duplicate invoices is a critical issue for business since duplicate invoices can result in a company paying more than once for goods or services ordered. Past experience has shown that generic duplicate record detection techniques are not very useful when applied to invoices: the rate of false positives can be so high that invoice clerks are discouraged from using the system. This is because such approaches do not take the business context into account, e.g. what types of good were ordered as well as the past relationship with that vendor. In this paper, we discuss applying Ripple Down Rules (RDR), an approach for incremental and end-user-centred knowledge acquisition, to the problem of classifying pairs of potential duplicate invoices. We describe how we built a prototype on top of the SAP ERP product and evaluated it on a real data set that had been previously independently audited for duplicates. The preliminary results have highlighted the significant potential of this approach for assisting invoicing clerks processing potential duplicate invoices. We have observed a drop in the rate of false positives from 92% down to 18.66% when compared to traditional approaches that do not take the business context into account. We suggest that incremental development of domain specific knowledge may have more general application to the problem of handling duplicate records.
Measurement of Dispersion Stability of Surface-Modified Nanosized Carbon Black in Various Liquids (2006)

The dispersion stability of nano-sized carbon black produced by a thermal plasma process was investigated using a novel multiple light scattering method. The effect of surface modification of carbon black on the dispersion stability was monitored in various polar and non-polar liquids including water, methanol, styrene, and toluene. The results show that carbon black functionalized with carboxylic anion groups has much improved colloidal stability in a polar solvent and the degree of dispersion stability is strongly related to the solubility parameter value of liquids. In addition, the carbon black with carboxylic anions has a long-term stability without any auxiliary dispersion agent such as a surfactant due to electrostatic repulsion.
Care in Practice (2010)

In what way is »care« a matter of »tinkering«? Rather than presenting care as a (preferably »warm«) relation between human beings, the various contributions to the volume give the material world (usually cast as »cold«) a prominent place in their analysis. Thus, this book does not continue to oppose care and technology, but contributes to rethinking both in such a way that they can be analysed together. Technology is not cast as a functional tool, easy to control - it is shifting, changing, surprising and adaptable. In care practices all »things« are (and have to be) tinkered with persistently. Knowledge is fluid, too. Rather than a set of general rules, the knowledges (in the plural) relevant to care practices are as adaptable and in need of adaptation as the technologies, the bodies, the people, and the daily lives involved.
Diagonal Antenna-Chassis Mode and Its Application for Wideband LTE MIMO Antennas in Mobile Handsets (2013)

Today, owners of small communicating device are interested in transmitting or receiving various multimedia data. By increasing the number of antennas at the transmitter and/or the receiver side of the wireless link, the diversity/Multiple-Input Multiple-Output (MIMO) techniques can increase wireless channel capacity without the need for additional power or spectrum in rich scattering environments. However, due to the limited space of small mobile devices, the correlation coefficients between MIMO antenna elements are very high and the total efficiencies of MIMO elements degrade severely. Furthermore, the human body causes high losses on electromagnetic wave. During the applications, the presence of users may result in the significant reduction of the antenna total efficiencies and highly affects the correlations of MIMO antenna systems. The aims of this thesis are to investigate and enhance the MIMO/diversity performance of multiple antenna systems in the free space and the presence of users.The background and theory of multiple antenna systems are introduced briefly first. Several figures of merits are provided and discussed to evaluate the multiple antenna systems. The decoupling techniques are investigated in the multiple antenna systems operating at the higher frequencies (above 1.7 GHz) and with high radiation efficiency. The single, dual and wide band isolation enhancements are realized through the half-wavelength decoupling slot, quarter-wavelength decoupling slot with T-shaped impedance transformer, tree-like parasitic element with multiple resonances, as well as the different polarizations and radiation patterns of multiple antennas.In the lower bands (lower than 960 MHz), due to the low radiation efficiency and strong chassis mode, the work mainly focused on how to directly reduce the correlations and enlarge the total efficiency. A new mode of mutual scattering mode is introduced. By increasing the Q factors, the radiation patterns of multiple antennas are separated automatically to reduce the correlations. With the inter-element distance larger than a certain distance, a higher Q factor also improved the total efficiency apart from the low correlation. A wideband LTE MIMO antenna with multiple resonances is proposed in mobile terminals. The high Q factors required for the low correlation and high efficiencies in mutual scattering mode is reduced with another mode of diagonal antenna-chassis mode. Hence, the bandwidth of wideband LTE MIMO antenna with multiple resonances mentioned above can be further enlarged while maintaining the good MIMO/diversity performance.The user effects are studied in different MIMO antenna types, chassis lengths, frequencies, port phases and operating modes. Utilizing these usefully information, an adaptive quad-element MAS has been proposed to reduce the user effects and the some geranial rules not limited to the designed MAS have also been given.
Low energy body design and nonlinear control of balance in a one legged robot (2004)

Postural control of a two degree of freedom hopping robot with a novel balancing mechanism is revisited. The balancing mechanism is a concave downward-swinging body whose center of gravity lies below the hip joint. It is shown that at a specific body curvature, the linearized system is transformed from non-minimum to minimum phase, the conditions for feedback linearization of the nonlinear model satisfied and minimal mechanical power required for stability during stance observed. Control of the nonlinear postural dynamics is then attempted using feedback linearization and its performance in achieving our control objective is compared against that of a linear quadratic regulator.
Tracking Multiple Unmanned Aerial Vehicles on SE(3) Using a Monocular Camera (2022)

This article presents MTT- <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex-math notation="LaTeX">$\text{SE}\mathopen {}(3)\mathclose {}$</tex-math></inline-formula> , a vision-based multiple-target tracking algorithm for targets that evolve on the special Euclidean group <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex-math notation="LaTeX">$\text{SE}\mathopen {}(3)\mathclose {}$</tex-math></inline-formula> in dense clutter. The target state consists of the pose in <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex-math notation="LaTeX">$\text{SE}\mathopen {}(3)\mathclose {}$</tex-math></inline-formula> and the twist of the vehicle. Contributions of the article include the development of a robust track initialization scheme designed on <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex-math notation="LaTeX">$\text{SE}\mathopen {}(3)\mathclose {}\times \mathbb {R}^{6}$</tex-math></inline-formula> , and a track-to-track association and fusion algorithm to merge similar tracks evolving on <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex-math notation="LaTeX">$\text{SE}\mathopen {}(3)\mathclose {}\times \mathbb {R}^{6}$</tex-math></inline-formula> . The performance of MTT- <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex-math notation="LaTeX">$\text{SE}\mathopen {}(3)\mathclose {}$</tex-math></inline-formula> is verified in hardware by simultaneously tracking three multirotors using a stationary monocular camera. The results are compared to a multiple-target tracking algorithm that uses linear, time-invariant nearly constant velocity, acceleration, and jerk models, where it is shown that MTT- <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex-math notation="LaTeX">$\text{SE}\mathopen {}(3)\mathclose {}$</tex-math></inline-formula> improves several traditional tracking metrics.
Effect of poly(vinylpyrrolidone) additive on the performance of poly(ether sulfone) ultrafiltration membranes (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffect of poly(vinylpyrrolidone) additive on the performance of poly(ether sulfone) ultrafiltration membranesLucie Y. Lafreniere, Frank D. F. Talbot, Takeshi Matsuura, and Srinivasa SourirajanCite this: Ind. Eng. Chem. Res. 1987, 26, 11, 2385–2389Publication Date (Print):November 1, 1987Publication History Published online1 May 2002Published inissue 1 November 1987https://pubs.acs.org/doi/10.1021/ie00071a035https://doi.org/10.1021/ie00071a035research-articleACS PublicationsRequest reuse permissionsArticle Views1178Altmetric-Citations139LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Supplementary Figures from Phosphoproteomics Identifies PI3K Inhibitor–selective Adaptive Responses in Pancreatic Cancer Cell Therapy and Resistance (2023)

&lt;p&gt;Supplementary Figures file contains merged Figure S1 to S8 including description of cell lines, Human samples, PI3K inhibitor stability, SILAC setup and controls, STRING analysis, quantifications of WB and cellular assays, prediction of kinase motifs found regulated, effects of combination of treatment in vitro, correlation between cell survival and phosphopeptide intensity, effects of combination treatment in Human samples and in vivo.&lt;/p&gt;
Hydrogels for in situ encapsulation of biomimetic membrane arrays (2010)

Abstract Hydrogels are hydrophilic, porous polymer networks that can absorb up to thousands of times their own weight in water. They have many potential applications, one of which is the encapsulation of freestanding black lipid membranes (BLMs) for novel separation technologies or biosensor applications. We investigated gels for in situ encapsulation of multiple BLMs formed across apertures in a hydrophobic ethylene tetrafluoroethylene (ETFE) support. The encapsulation gels consisted of networks of poly(ethylene glycol)‐dimethacrylate or poly(ethylene glycol)‐diacrylate polymerized using either a chemical initiator or a photoinitiator. The hydrogels were studied with regards to volumetric stability, porosity, and water permeability. All hydrogels had pore sizes around 7 nm with volumetric changes &gt;2% upon crosslinking. Photoinitiated hydrogels had a lower hydraulic water permeability compared to chemically initiated hydrogels; however, for all hydrogels the permeability was several‐fold higher than the water permeability of conventional reverse osmosis (RO) membranes. Lifetimes of freestanding BLM arrays in gel precursor solutions were short compared to arrays formed in buffer. However, polymerizing (crosslinking) the gel stabilized the membranes and resulted in BLM arrays that remained intact for days. This is a substantial improvement over lifetimes for freestanding BLM arrays. Optical images of the membranes and single channel activity of incorporated gramicidin ion channels showed that the lipid membranes retained their integrity and functionality after encapsulation with hydrogel. Our results show that hydrogel encapsulation is a potential means to provide stability for biomimetic devices based on functional proteins reconstituted in biomimetic membrane arrays. Copyright © 2010 John Wiley &amp; Sons, Ltd.
Phosphorylation and partial sequence of pregnant sheep myometrium myosin light chain kinase (1995)

The function of the uterine smooth muscle in gestation and parturition is affected by a variety of hormones and biomolecules, some of which alter the intracellular levels of cAMP and Ca2+. Since the activity of smooth muscle MLCK has been shown to be modulated by phosphorylation, the effect of this modification of pregnant sheep myometrium (psm) MLCK by the catalytic subunit of cAMP-dependent protein kinase (PKA) and protein kinase C (PKC) was studied. In contrast to other smooth muscle MLCK reported, PKA incorporates 2.0–2.2 moles phosphate into a mole of psm MLCK both in the presence and absence of Ca2+-calmodulin. Modification of serine residues inhibited the activity of the enzyme. PKC also incorporated 2.0–2.1 moles of phosphate per mole psmMLCK under both conditions but had no effect on the MLCK activity. Sequential phosphorylation by PKC and PKA incorporated 3.8–4.1 moles phosphate suggesting that the amino acid residues modified by the two kinases are different. Phosphoamino acid analysis of the MLCK revealed that PKC phosphorylated serine and threonine residues. The double reciprocal plots of the enzyme activity and calmodulin concentrations showed that the Vmax of the reaction is not altered by phosphorylation by PKA but the calmodulin concentration require for half-maximal activation is increased about 4-fold. Only 10 out of 17 monoclonal antibodies to various regions of the turkey gizzard MLCK cross-reacted with psmMLCK suggesting structural differences between these enzymes. Comparison of the deduced amino acid sequence of the cDNA encoding the C-terminal half of the psmMLCK molecule showed that while cgMLCK and psmMLCK are highly homologous, a number of nonconservative substitutions are present, particularly near the PKA phosphorylation site B (S828).
Fate of Salmonella montevideo on and in raw tomatoes as affected by temperature and treatment with chlorine (1995)

A study was undertaken to determine the survival patterns of Salmonella montevideo G4639 on and in tomatoes during storage and the efficacy of chlorine treatment on inactivation of the pathogen. The population of S. montevideo on the surfaces of inoculated tomatoes stored at 10 degrees C did not change significantly (P < 0.05) throughout an 18-day storage period. Significant increases in population occurred within 7 days and within 1 day when tomatoes were stored at 20 and 30 degrees C, respectively. A significantly higher number of cells was taken up by the core tissue of tomatoes tempered at 25 degrees C when the tomatoes were dipped in a suspension at 10 degrees C compared with the number taken up when the tomatoes were dipped in cell suspensions tempered at 25 or 37 degrees C. Populations remained constant throughout subsequent storage for 8 days at 10 degrees C, regardless of the temperature differential between tomatoes and the dip suspension. Storage of tomatoes at 20 degrees C, however, resulted in significant increases in populations of S. montevideo. Populations of the pathogen on the surfaces and in the core tissues of tomatoes were significantly reduced by dipping for 2 min in a solution containing 60 or 110 ppm (60 or 110 micrograms/ml) chlorine, respectively; however, treatment in solution containing 320 ppm chlorine did not result in complete inactivation. Populations of S. montevideo remained unchanged in chopped tomatoes stored at 5 degrees C for 216 h (9 days) but increased significantly after storage for 96 or 22 h at 20 or 30 degrees C, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
Gelatin based microfluidic devices for cell culture (2006)

We have developed a technique for fabricating microfluidic devices from gelatin using a natural crosslinking process. Gelatin, crosslinked with the naturally occurring enzyme transglutaminase is molded to produce microchannels suitable for adherent cell culture and analysis. The autofluorescence of the material was shown to be minimal and within the range of typical background, ensuring utility with analyses using fluorescent dyes and labels would not be affected. Also, normal murine mammary epithelial cells were successfully cultured in the microchannels. The morphology of these adherent epithelial cells was shown to be significantly different for cells grown on rigid tissue culture plastic in either macro- or microscale cultures (even in the presence of a surface coating of gelatin) than those grown on the flexible crosslinked gelatin microchannels. Using these devices, the effects of both the extracellular matrix and soluble factors on cellular behavior and differentiation can be studied in microenvironments that more closely mimic the in vivo environment.
Fragment adaptive reduction: coping with various interferers in radio unlicensed bands (2002)

This paper studies the impact of common interferers found in unlicensed bands on 802.11 and other CSMA systems. First, we describe those interferers and the MAC techniques used to combat them. Then, we present fragment adaptive reduction, a scheme to overcome the effect of non-CSMA repetitive interferers, and it's implementation in the SWAP protocol. We also describe a simple model of domestic microwave oven interference. We finish by some exhaustive simulations of the impact of microwave oven and other interferers on 802.11, which illustrate the benefits of the fragment reduction scheme.
Copper quantum cluster-polypyrrole composite film based zero current chronopotentiometric sensor for glutathione (2012)

We report, for the first time, a potentiostatically deposited copper quantum cluster (CuQC) and CuQC-polypyrrole composite film modified copper disc electrode prepared under the seemingly unlikely conditions of deposition at +0.8 V vs. Ag/AgCl for 100 s from tetrabutylammonium bromide (R4N+Br−) and, R4N+Br− and pyrrole solutions. By employing zero current chronopotentiometry, the electrode response was linear from 10−6 to 10−4 M of glutathione with a limit of detection of 2.6 × 10−7 M and a precision of 4.3% (at 10−6 M). Spectral and morphological characterizations revealed that each quantum cluster is an aggregate of ∼2 nm size consisting of several sub nm sized particles. Furthermore, the designed glutathione sensor is selective with respect to amino acids, ascorbic acid, uric acid and glucose. The quantification of glutathione in human urine was successfully tested and recoveries on standard addition were found to be quantitative.
Adaptive Resource Provisioning based on Application State (2019)

Infrastructure providers employing Virtual Network Functions (VNFs) in a cloud computing context need to find a balance between optimal resource utilization and adherence to agreed Service Level Agreements (SLAs). Tenants should be allocated as much computing, storage and network capacity as they need in order not to violate SLAs, but not more so that the infrastructure provider can accommodate more tenants to increase revenue. This paper presents an optimizer VNF that ensures that a given virtual machine (VM) is sufficiently utilized before directing traffic to another VM, and an orchestrator VNF that scales the number of VMs up or down as needed when workloads change, thereby limiting the number of active VMs to a minimum that can deliver the service. We setup a testbed to transcode and stream Video on Demand (VoD) as a service. We present experimental results which show that when the optimizer and orchestrator are used together they outperform static provisioning in terms of both resource utilization and service response times.
The ER membrane protein complex promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis (2018)

The eukaryotic endoplasmic reticulum (ER) membrane contains essential complexes that oversee protein biogenesis and lipid metabolism, impacting nearly all aspects of cell physiology. The ER membrane protein complex (EMC) is a newly described transmembrane domain (TMD) insertase linked with various phenotypes, but whose clients and cellular responsibilities remain incompletely understood. We report that EMC deficiency limits the cellular boundaries defining cholesterol tolerance, reflected by diminished viability with limiting or excessive extracellular cholesterol. Lipidomic and proteomic analyses revealed defective biogenesis and concomitant loss of the TMD-containing ER-resident enzymes sterol-O-acyltransferase 1 (SOAT1) and squalene synthase (SQS, also known as FDFT1), which serve strategic roles in the adaptation of cells to changes in cholesterol availability. Insertion of the weakly hydrophobic tail-anchor (TA) of SQS into the ER membrane by the EMC ensures sufficient flux through the sterol biosynthetic pathway while biogenesis of polytopic SOAT1 promoted by the EMC provides cells with the ability to store free cholesterol as inert cholesteryl esters. By facilitating insertion of TMDs that permit essential mammalian sterol-regulating enzymes to mature accurately, the EMC is an important biogenic determinant of cellular robustness to fluctuations in cholesterol availability.This article has an associated First Person interview with the first author of the paper.