gebhart/patrepeval huggingface dataset:
A Vision for Open Science (2018)

Funders are well positioned to shift the incentives for open science inherent in grant application processes and improve the way research is evaluated. Institutions can change the<em> status quo</em> by promoting and rewarding researchers'careers, and collaborating with research libraries in contributing to development of the European Open Science Cloud (EOSC) infrastructure, tools and relevant skills. This document elaborates on the outcome of the workshop "Research Institutions and Libraries and the role of Funders in the European Open Science Cloud" held at the LIBER 2018 Conference in Lille, France. It sets a vision in which open science is the norm, and all funding bodies as well as institutions and researchers recognise the benefit of open science and embed best open science practice into their processes.
Proximal promoter binding protein contributes to developmental, tissue‐restricted expression of the rat osteocalcin gene (1995)

Osteocalcin is a 6 kD tissue-specific calcium binding protein associated with the bone extracellular matrix. The osteocalcin gene is developmentally expressed in postoproliferative rat osteoblasts with regulation at least in part at the transcriptional level. Multiple, basal promoter and enhancer elements which control transcriptional activity in response to physiological mediators, including steroid hormones, have been identified in the modularly organized osteocalcin gene promoter. The osteocalcin box (OC box) is a highly conserved basal regulatory element residing between nucleotides -99 and -76 of the proximal promoter. We recently established by in vivo competition analysis that protein interactions at the CCAAT motif, which is the central core of the rat OC box, are required for support of basal transcription [Heinrichs et al. J Cell Biochem 53:240-250, 1993]. In this study, by the combined utilization of electrophoretic mobility shift analysis, UV cross linking, and DNA affinity chromatography, we have identified a protein that binds to the rat OC box. Results are presented that support involvement of the OC box-binding protein in regulating selective expression of the osteocalcin gene during differentiation of the rat osteoblast phenotype and suggest that this protein is tissue restricted.
Bilateral isolated choroidal melanocytosis (2008)

There is conflicting evidence about the effect of parental consanguinity on fetal growth. Previous studies have not always allowed for other factors that are known to affect birth weight, in particular, gestational age, parity, and maternal height. We have therefore studied this question in the Pakistani Moslem population in Birmingham. Babies born to parents who were first cousins were on average 80 g lighter than those born to unrelated parents, but this difference was not significant for the size of the sample studied. Nor were there any differences in the other measurements of the babies. After expressing birth weight in terms of centiles for gestational age, sex, parity, and maternal height, however, while there was no difference in the overall distribution of centiles, there were more poorly grown babies--that is, weight below the 10th centile--in the first cousin group. We conclude that parental consanguinity is associated with an increase in the number of poorly grown babies but that the overall effect on mean birth weight is small.
2-Benzazolyl-4-Piperazin-1-Ylsulfonylbenzenecarbohydroxamic Acids as Novel Selective Histone Deacetylase-6 Inhibitors with Antiproliferative Activity (2015)

We have screened our compound collection in an established cell based assay that measures the derepression of an epigenetically silenced transgene, the locus derepression assay. The screen led to the identification of 4-[4-(1-methylbenzimidazol-2-yl)piperazin-1-yl]sulfonylbenzenecarbohydroxamic acid (9b) as an active which was found to inhibit HDAC1. In initial structure activity relationships study, the 1-methylbenzimidazole ring was replaced by the isosteric heterocycles benzimidazole, benzoxazole, and benzothiazole and the position of the hydroxamic acid substituent on the phenyl ring was varied. Whereas compounds bearing a para substituted hydroxamic acid (9a-d) were active HDAC inhibitors, the meta substituted analogues (8a-d) were appreciably inactive. Compounds 9a-d selectively inhibited HDAC6 (IC50 = 0.1-1.0 μM) over HDAC1 (IC50 = 0.9-6 μM) and moreover, also selectively inhibited the growth of lung cancer cells vs. patient matched normal cells. The compounds induce a cell cycle arrest in the S-phase while induction of apoptosis is neglible as compared to controls. Molecular modeling studies uncovered that the MM-GBSA energy for interaction of 9a-d with HDAC6 was higher than for HDAC1 providing structural rationale for the HDAC6 selectivity.
Dissipative Coefficients of Superfluid Helium (1973)

The linearized hydrodynamic equations for superfluid ${\mathrm{He}}^{4}$ are derived starting from the kinetic equations of Khalatnikov. Only the lowest-order dissipative terms are considered. The Boltzmann equation for the phonons and rotons is solved formally by expanding the distribution function in terms of the eigenfunctions of the linearized collision operator. The resulting hydrodynamic equations contain dissipative terms of the form proposed by Landau and Khalatnikov. Formal expressions are given for the viscosities and the thermal kinetic coefficient. Finally, relations which may hold between the dissipative coefficients when the collision operator has special properties are discussed.
Author response: Stem cell progeny contribute to the schistosome host-parasite interface (2016)

Schistosomes are parasitic worms that infect and cause chronic disease in hundreds of millions of people in the developing world. A major reason these parasites are so damaging is that they are capable of living and reproducing in the human bloodstream for decades. Previous research had shown that schistosomes have a population of stem cells that are proposed to promote the parasite’s survival inside the host’s bloodstream. However, it was not clear what role these cells play in the worms. Collins et al. have now found that, in a parasitic worm called Schistosoma mansoni, a large number of these stem cells are destined to become cells that generate the parasite’s skin. This unique tissue is known as the tegument, and had long been thought to have evolved in parasitic flatworms to help them survive in their host and evade its immune defenses. Therefore, Collins et al.’s findings suggest a new mechanism by which stem cells can promote the survival of a parasite inside its host. In the long-term, these findings could lead to new treatments for parasitic infections and may shed light on the evolution of parasitic flatworms. An important future challenge will be to determine if disrupting these parasites’ stem cells, and their ability to generate new tegumental cells, has any effect on the parasite inside its host.
Corrections in the Pioneer Venus Sounder Probe Gas Chromatographic Analysis of the Lower Venus Atmosphere (1980)

Misidentification of two peaks from the Pioneer Venus sounder probe gas chromatograph (SPGC), also formerly known as the LGC, gave rise to quantitative errors in the abundances of oxygen, argon, and carbon monoxide. The argon abundance is estimated at 67 parts per million and that of carbon monoxide at 20 parts per million. At this time, no estimates for the oxygen abundance can be made.
Stroke MRI (2003)

Stroke MRI is a new imaging tool providing detailed information of the pathophysiological aspects of cerebral ischemia. This book with CD-ROM includes a case collection of 25 hyperacute stroke patient
Relative roles of follicle-stimulating hormone and luteinizing hormone in the control of inhibin secretion in normal men. (1988)

The glycoprotein hormone inhibin is produced by the Sertoli cells of the testis under the influence of follicle-stimulating hormone (FSH) and is postulated in turn to inhibit FSH secretion. Luteinizing hormone (LH) is not recognized to have an important role in the control of inhibin secretion in any species. To determine the relative roles of FSH and LH in the control of inhibin secretion in man, we examined the effects of selective FSH and LH replacement on serum inhibin levels in normal men whose endogenous gonadotropins were suppressed by testosterone (T). After a 3-mo control period, nine men received 200 mg T enanthate i.m. weekly for 3-9 mo. During T treatment, serum LH and FSH levels were markedly suppressed and serum inhibin levels fell to 40% of control values. While continuing T, 3-5 mo of treatment with purified hFSH (n = 4) or hLH (n = 4) increased the respective serum gonadotropin level into the upper normal range and significantly increased inhibin levels back to 64 and 55% of control values, respectively. Supraphysiological LH replacement with high doses of human chorionic gonadotropin (n = 3) returned serum inhibin levels to 63% of control values. In no case did inhibin levels return fully to control levels. In conclusion, serum inhibin levels fell during gonadotropin suppression and were partially and approximately equally restored by either FSH or LH treatment. FSH presumably acts directly on the Sertoli cell to increase inhibin secretion whereas LH may act via increases in intratesticular T levels and/or other factor(s).
Adverse reactions to contrast media in CT: effects of temperature and ionic property. (1996)

In outpatient CT examinations, nonionic, warmed contrast medium was the best option because no severe reactions resulted from its use. Prevalence of adverse reactions was comparable to that in controlled randomized studies.
Infrared system for intermittent Automatic train protection (2015)

In order to prevent collision of the train movement or derailment, Automatic train protection (ATP) is needed as an important part of signaling system. Conventionally, a transponder or electro-magnet is used for communication between trackside device and onboard device of the ATP. ATP is not applied yet in Indonesia till now and all trains are operated by driver. So, ATP is become a necessity to protect the train operation in Indonesia. In other hand, performance of trackside equipment is also influenced by some environment problems such as heavy rain and theft of the equipment. Furthermore, some particular criteria such as low cost configuration, minimalized devices on the track, easy to maintenance, etc. have to be fulfilled by installed devices on trackside in order to solve the environment problems. We propose infrared system for automatic train protection in order to address the necessity and to meet the particular criteria. This ATP is the intermittent automatic train protection that is divided into onboard and trackside equipment. The onboard equipment consists of receiver of infrared, detecting and processing train speed, alarm and brake, detecting system error, logger, and power on self-test. The trackside equipment is formed of infrared transmitter that has function as the transducer. A cost-effective solution and ensures safety of train movement are covered by the ATP.
Transurethral microwave thermal therapy: Pathologic findings in the canine prostate (1995)

Microwave irradiation administered by transurethral transducer to the prostate permits focused hyperthermia with resultant tissue ablation; a coding system within the catheter allows urethral preservation. We evaluated the effect of microwave hyperthermia in 13 dogs receiving 48-79 min of focused irradiation (16-45 watts, intraprostatic temperature > 45 degrees C) delivered by a specially-designed transducer with an operator-controlled directional antenna (T3, Urologix Inc., Minneapolis, MN); one other dog had transducer placement without irradiation (sham control). After treatment, the dogs were in good health, voiding well without complications, and were sacrificed after 5-38 days. The prostate and vasa deferentia were removed, fixed in 10% formalin, grossly inspected, cut at 5 mm intervals, and serially sectioned with whole mount sections; representative sections of the adjacent rectum and distal bladder were also obtained. All cases were histologically evaluated with prostatic mapping without knowledge of treatment or time of sacrifice. In the acute phase (5-13 days), the prostate showed sharply circumscribed periurethral coagulative necrosis with hemorrhage; necrosis was also seen in the mucosa and bladder wall of those with transducers placed at the bladder neck. In the subacute phase (17 days), the hemorrhagic necrosis was resolving, often with cystically dilated urethra due to sloughed necrotic tissue; the urothelium was intact. By 24-38 days, the necrosis was in the late stages of resolution, with residual patchy acute and chronic inflammation at the periphery, and frequent persistence of megalourethra. In all cases, the prostatic capsule was intact, the urethral mucosa was preserved, and the vasa deferentia and rectum were normal except for two cases with mild fat necrosis. Microwave irradiation allows precisely localized thermal ablation of prostatic tissue and enlargement of the urethral bore without clinical complications in dogs, offering promise as a therapeutic alternative to surgery in select patients with symptomatic prostatic nodular hyperplasia.
Novel optical line codes tolerant to fiber chromatic dispersion (2001)

A novel family of optical line codes to counteract the effects of a dispersive fiber is presented. The performance of the first code in the family, referred to as order-1 code, is analytically evaluated and compared to that of the duobinary and phased amplitude-shift signaling (PASS) codes, which are a modified form of duobinary proposed by Stark et al. (1999). The order-1 line code turns out to be very robust to chromatic dispersion and, for a given penalty, allows the bridging of a distance 1.5 times (or more) greater than duobinary. The novel family of codes was conceived by exploiting the finding that, approximately, a very dispersive fiber turns an input pulse into the form of its Fourier transform seen in the time domain. Higher-order codes allow the bridging of larger distances if combined with appropriate chirping.
A double-blind comparative evaluation of aspirin, paracetamol and paracetamol + caffeine (finimal) for their analgesic effectiveness. (1977)

A double-blind, cross-over trial was made of three analgesic preparations--paracetamol, paracetamol with caffeine (Finimal) and aspirin in the relief of postoperative pain in 72 orthopedic inpatients and in 144 ambulatory outpatients suffering form common idiopathic headache. The combination of paracetamol and caffeine (Finimal) in this study shows the greatest pain relief in both groups of patients. This evaluation supports the results of BOOY3 demonstrating the superiority of the paracetamol-caffeine combination to paracetamol alone or aspirin.
Growth of Indigenous Organisms in Aerated Filtrate of Feedlot Waste (1974)

Filtrates from feedlot waste were incubated under aerobic conditions to evaluate the availability of nutrients for cell production and to assess the capacity of indigenous flora to produce stabilized effluents. Incubation was carried out in 9-liter aerated jar fermentors. Three-fourths of the organic material and one-third of the nitrogen were taken up in 4 days; 90% utilization of organic material and nitrogen required almost a month. Acid was produced initially, but aerated liquid thereafter rapidly became alkaline. With pH controlled at 7.0, a comparable pattern of carbon utilization occurred, but nitrogen was incompletely used. The numerically dominant organisms in the waste inoculum were almost immediately displaced by an emergent population of a few types of organisms not originally evident. Maximal viable populations of 10(9) to 3 x 10(9) cells/ml were obtained in aerated waste liquid within 48 h; subsequently, numbers declined quickly to initial levels. Numbers of fungi, yeasts, and streptomycetes slowly increased but never exceeded their initial concentration by more than tenfold.
A dialogue management system using a corpus-based framework and a dynamic dialogue transition model (2013)

We propose a novel practical dialogue management system that satisfies the requirements of robust dialogue management, efficient domain knowledge construction, and flexible architecture for maintenance and extensibility. The proposed system uses a co
A unique endoglucanase-encoding gene cloned from the phytopathogenic fungus Macrophomina phaseolina (1995)

The deduced amino acid sequence derived from a Macrophomina phaseolina beta-1,4-endoglucanase-encoding gene revealed 48% identity (over 119 amino acids) with egl1 from the phytopathogen Pseudomonas solanacearum. Its similarity to saprophyte endoglucanases was not significant. Its minimum substrate size, unlike that of any known saprophyte endoglucanase, was cellopentaose. The unique characteristics of M. phaseolina egl1-encoded endoglucanase suggest that it is phytopathogen specific.
Combined Numerical and Experimental Determination of Ball Bearing Capacitances for Bearing Current Prediction (2020)

High-frequency voltages across the steel ball bearings and the corresponding currents can cause premature bearing failures in electric machines driven by PWM converters. The bearing voltage, one of the most commonly-used failure indicators, depends heavily on the bearing capacitance. This paper presents a combined numerical and experimental approach for the calculation of ball bearing capacitances to address the uncertainty introduced by lubricant property, lubrication status and other metal parts, such as seals and ball retainers. Based on the obtained capacitance breakdown, the influences of temperature, speed and bearing load (radial, axial or combined) on the capacitance are studied. Measurements and associated results of bearing capacitances are provided to validate the proposed method.
New Approximation Algorithms for Minimum Enclosing Convex Shapes (2011)

Given n points in a d dimensional Euclidean space, the Minimum Enclosing Ball (MEB) problem is to find the ball with the smallest radius which contains all n points. We give two approximation algorithms for producing an enclosing ball whose radius is at most ε away from the optimum. The first requires O(nd£/√ε) effort, where C is a constant that depends on the scaling of the data. The second is a O∗ (ndQ/√ε) approximation algorithm, where Q is an upper bound on the norm of the points. This is in contrast with coresets based algorithms which yield a O(nd/ε) greedy algorithm. Finding the Minimum Enclosing Convex Polytope (MECP) is a related problem wherein a convex polytope of a fixed shape is given and the aim is to find the smallest magnification of the polytope which encloses the given points. For this problem we present O(mnd£/ε) and O∗(mndQ/ε) approximation algorithms, where m is the number of faces of the polytope. Our algorithms borrow heavily from convex duality and recently developed techniques in non-smooth optimization, and are in contrast with existing methods which rely on geometric arguments. In particular, we specialize the excessive gap framework of Nesterov [19] to obtain our results.
Presynaptic Cholinergic Modulators as Potent Cognition Enhancers and Analgesic Drugs. 2. 2-Phenoxy-, 2-(Phenylthio)-, and 2-(Phenylamino)alkanoic Acid Esters (1994)

Further modifications of the leads ((R)-(+)-hyoscyamine and (p-chlorophenyl)propionic acid alpha-tropanyl ester), which show analgesic and nootropic activities as a consequence of increased central presynaptic ACh release, are reported. 2-Phenoxy- and 2-(phenylthio)alkanoic acid esters showed the best results. Several members of these classes possess analgesic properties which are comparable to that of morphine and at the same time are able to reverse dicyclomine-induced amnesia. Confirmation was found that the mechanism of action is due to an increase in ACh release at central muscarinic synapses and that both auto- and heteroreceptors controlling ACh release are very likely involved. According to the results obtained with (R)-(+)-hyoscyamine, analgesic activity is stereochemistry dependent, since the R-(+)-enantiomers are always more efficacious than the corresponding S-(-)-ones. On the basis of their potency and acute toxicity, compounds (+/-)-28 (SM21) and (+/-)-42 (SM32) were selected for further study.
All-optical tunable pulse frequency chirp via slow light (2009)

We theoretically investigate slow light via stimulated Raman scattering, paying special attention to the picosecond regime where chromatic dispersion and cross-phase modulation must be considered. In addition to the control of the Raman pulse walk-off, we demonstrate that the cross-phase-modulation-induced frequency chirp can also be all-optically tuned via Raman slow light. We further demonstrate that this new implication is a consequence of the fact that the group velocity is significantly more affected than the phase velocity in slow-light media.
A simple and flexible calibration method of non-overlapping camera rig (2015)

A simple and flexible method for non-overlapping camera rig calibration that includes camera calibration and relative poses calibration is presented. The proposed algorithm gives the solutions of the cameras parameters and the relative poses simultaneously by using nonlinear optimization. Firstly, the intrinsic and extrinsic parameters of each camera in the rig are estimated individually. Then, a linear solution derived from hand-eye calibration scheme is proposed to compute an initial estimate of the relative poses inside the camera rig. Finally, combined non-linear refinement of all parameters is performed, which optimizes the intrinsic parameters, the extrinsic parameters and relative poses of the coupled camera at the same time. We develop and test a novel approach for calibrating the parameters of non-overlapping camera rig using camera calibration and hand-eye calibration method. The method is designed inter alia for the purpose of deformation measurement using the calibrated rig. Compared the camera calibration with hand-eye calibration separately, our joint calibration is more convenient in practice application. Experimental data shows our algorithm is feasible and effective.
Sliding window prior data assisted compressed sensing for MRI tracking of lung tumors (2017)

In this work we demonstrated the negative impact of slow changes in MR signal for longer duration PDACS dynamic scans, namely increases in image artifact power and reductions of tumor tracking accuracy. We have also demonstrated sliding window implementations (i.e., refreshing of prior data) of PDACS are effective solutions to this problem at both 3 T and simulated 0.5 T bSSFP images.
Experimental estimation of a 5-axis active control type bearingless canned motor pump (2011)

Bearingless motors are characterized by integration of electrical motors and magnetic bearings. These motors can realize magnetic suspension of rotor shafts without mechanical contacts. If the bearingless motor is applied to a canned motor pump, it is possible to levitate and rotate a impeller and a rotor shaft of a centrifugal pump. Therefore, the bearingless canned motor pump can realize next several advantages; (1) high power and high head, (2) clean liquid sending, (3) maintenance free, (4) longer operating life, (5) high chemical resistance. On the other hand, the rotor shaft and the stator must be covered with thick bulkheads, because fluid flows into the gap between the rotor shaft and the stator. It becomes difficult to generate sufficient suspension force for magnetic suspension, as a magnetic gap length is increased by the thick bulkheads. Accordingly, a novel structure of a 5-axis active control type bearingless motor, that can generate the sufficient suspension force under the wide-gap condition, has been proposed. This paper introduces pump characteristics with experiments using a prototype of the proposed novel structure.