gebhart/patrepeval huggingface dataset:
Trellis-hopping turbo coding (2006)

We present a turbo coding scheme whose constituent codes are designed using convolutional encoders with time-varying coefficients. These encoders are finite state sequence machines that operate over the Galois field GF(q). The scheme includes an encryption polynomial whose coefficients are changed periodically by means of a user key. The trellis coding procedure thus hops from one trellis to another, following a random sequence taken over a set of subtrellises which correspond to different convolutional encoders. The proposed scheme is introduced as a turbo code with encryption properties, and is presented in two forms, the systematic and the nonsystematic schemes.
Potent 6-Desfluoro-8-methylquinolones as New Lead Compounds in Antibacterial Chemotherapy (1996)

In a furtherance of our SAR study on the C-6 position of quinolone antibacterials, a series of 6-desfluoro-8-methylquinolones were synthesized and evaluated for their in vitro antimicrobial activity. As a result of this study, compounds with strong activity against Gram-positive bacteria, including ciprofloxacin-resistant and methicillin-resistant Staphylococcus aureus, were identified. The best Gram-positive antibacterial activity was exhibited by piperidinyl derivative 6c, which was 17 times more potent than ciprofloxacin and displayed extremely high activity against Streptococcus pneumoniae with an MIC value of <0.016 microg/mL. Thus, we have shown that substituent combinations in the quinolone ring, excluding the C-6 fluorine atom, might produce powerful antibacterial agents.
Pathways to Involution of Nevi (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Crack and Damage Velocities in Ballistic Experiments (2014)

A series of ballistic impact experiments were conducted against a borosilicate glass (Borofloat ® 33) bonded to a polycarbonate substrate. Two of the objectives of the experiments were to measure crack velocities in the glass, and to measure the damage velocity in the glass. The speed of distinct propagating cracks was found to be 1.92 ± 0.03 km/s, independent of impact velocity. The maximum rate of damage propagation was found to be a function of impact velocity, but the damage velocity plateaued at 2.07 ± 0.04 km/s.
The Importance of Antibody-Specificity in Determining Successful Radioimmunotherapy of B-Cell Lymphoma (1999)

We report the radioimmunotherapy of mouse B-cell lymphoma, BCL1, using a panel of anti-B-cell monoclonal antibodies (MoAb) (anti-CD19, anti-CD22, anti-major histocompatibility complex (MHC) II, and anti-idiotype (Id) radiolabeled with 131-iodine. When administered early in disease (day 4), the 131I-anti-MHCII MoAb cured tumors as a result of targeted irradiation alone, the unlabeled MoAb being nontherapeutic. In contrast, 131I-anti-Id, despite targeting irradiation and having therapeutic activity as an unconjugated antibody, protected mice for only 30 days; 131I-anti-CD19 and anti-CD22 were therapeutically inactive. Binding and biodistribution studies showed that the anti-Id, unlike anti-MHCII, MoAb was cleared from target cells in vivo and delivered 4 times less irradiation to splenic tumor. Treating later in the disease (day 14) increased tumor load and produced the expected reduction in therapeutic activity with the anti-MHCII, but surprisingly, allowed 131I-anti-Id to cure most mice. This unexpected potency of 131I-anti-Id late in the disease appeared to result from the direct cytotoxicity of the anti-Id MoAb, which was more active in established disease, in combination with targeted irradiation. We believe the ability of targeted irradiation and certain cytotoxic MoAb to work cooperatively against tumor in this way has important implications for the selection of reagents in radioimmunotherapy of B-cell lymphoma.
Sustained Wave Transmission Chart (1917)

The Sommerfeld, Austin, Fuller, and Eccles transmission formulas are compared with available data, and the conclusion reached that the Austin formula is most nearly correct. A chart is given whereby, given any five of the six quantities: wave length, transmitting and receiving antenna heights, distance of transmission, transmitting current, and received audibility, the sixth can readily be obtained. Tho specially intended for sustained wave reception using the ultraudion, it is shown that the chart can also be used for other detectors and damped wave reception.
Impact of Tilapia hepcidin 2-3 dietary supplementation on the gut microbiota profile and immunomodulation in the grouper (Epinephelus lanceolatus) (2019)

Hepcidin regulates iron homeostasis and host-defense mechanisms, while the hepcidin-like protein, Tilapia hepcidin (TH)2-3, functions as an antimicrobial peptide (AMP). Since AMP dietary supplements may be used as alternatives to antibiotics in livestock, we tested the effects of recombinant (r)TH2-3 as a dietary supplement in grouper aquaculture. rTH2-3 was produced by a Pichia pastoris expression system and exhibited thermostability and broad-spectrum antimicrobial activity. The feed conversion ratio and feed efficiency were determined in Epinephelus lanceolatus (grouper) fed with rTH2-3-supplemented diet for 28 days. In addition, grouper showed enhanced superoxide dismutase (SOD) activity after rTH2-3 feeding compared to regular-diet-fed fish. Gut microbiota analysis revealed that microbial diversity was enhanced by feeding grouper with 1% rTH2-3. After challenging grouper with Vibrio alginolyticus, differential regulation of immune-related genes in the liver and spleen was observed between the TH2-3 and regular-diet groups, including for genes associated with antimicrobial and pro-inflammatory functions, complement components, and major histocompatibility complex (Mhc). These findings suggest that overall immunity was improved. Thus, our results suggest long-term supplementation with rTH2-3 may be beneficial for aquacultured grouper. The beneficial effects of the supplement are likely based on changes in the commensal microbial community as well as immunomodulation.
Partial Purification of a Megadalton DNA Replication Complex by Free Flow Electrophoresis (2016)

We describe a gentle and rapid method to purify the intact multiprotein DNA replication complex using free flow electrophoresis (FFE). In particular, we applied FFE to purify the human cell DNA synthesome, which is a multiprotein complex that is fully competent to carry-out all phases of the DNA replication process in vitro using a plasmid containing the simian virus 40 (SV40) origin of DNA replication and the viral large tumor antigen (T-antigen) protein. The isolated native DNA synthesome can be of use in studying the mechanism by which mammalian DNA replication is carried-out and how anti-cancer drugs disrupt the DNA replication or repair process. Partially purified extracts from HeLa cells were fractionated in a native, liquid based separation by FFE. Dot blot analysis showed co-elution of many proteins identified as part of the DNA synthesome, including proliferating cell nuclear antigen (PCNA), DNA topoisomerase I (topo I), DNA polymerase δ (Pol δ), DNA polymerase ɛ (Pol ɛ), replication protein A (RPA) and replication factor C (RFC). Previously identified DNA synthesome proteins co-eluted with T-antigen dependent and SV40 origin-specific DNA polymerase activity at the same FFE fractions. Native gels show a multiprotein PCNA containing complex migrating with an apparent relative mobility in the megadalton range. When PCNA containing bands were excised from the native gel, mass spectrometric sequencing analysis identified 23 known DNA synthesome associated proteins or protein subunits.
Advanced Hough-based method for on-device document localization (2021)

The demand for on-device document recognition systems increases in conjunction with the emergence of more strict privacy and security requirements. In such systems, there is no data transfer from the end device to a third-party information processing servers. The response time is vital to the user experience of on-device document recognition. Combined with the unavailability of discrete GPUs, powerful CPUs, or a large RAM capacity on consumer-grade end devices such as smartphones, the time limitations put significant constraints on the computational complexity of the applied algorithms for on-device execution. In this work, we consider document location in an image without prior knowledge of the document content or its internal structure. In accordance with the published works, at least 5 systems offer solutions for on-device document location. All these systems use a location method which can be considered Hough-based. The precision of such systems seems to be lower than that of the state-of-the-art solutions which were not designed to account for the limited computational resources. We propose an advanced Hough-based method. In contrast with other approaches, it accounts for the geometric invariants of the central projection model and combines both edge and color features for document boundary detection. The proposed method allowed for the second best result for SmartDoc dataset in terms of precision, surpassed by U-net like neural network. When evaluated on a more challenging MIDV-500 dataset, the proposed algorithm guaranteed the best precision compared to published methods. Our method retained the applicability to on-device computations.
PD15-01 THE IMPACT OF 2011 UNITED STATES PREVENTIVE SERVICES TASK FORCE PANEL UPDATE ON PSA SCREENING PRACTICE: A NATIONWIDE, AND STATE-BY-STATE LEVEL ANALYSES. (2016)

127 (73%) tumors: FG1 (18.9%), FG2 (63.7%), FG3 (15.7%), and FG4 (1.6%). While the majority were pT1a (87%) tumors, 9%, 1.3%, and 2.6% were pT1b, pT2a, pT3a, respectively. Tumors were managed by partial nephrectomy (67.5%), radical nephrectomy (19.4%), percutaneous radiofrequency ablation (10.4%), and cryoablation (2.4%). Of the 131 patients who underwent nephron-sparing interventions, 7.6% returned to dialysis and 5.3% developed tumor recurrence, during a mean follow-up of 2.85 years. Of those who had partial nephrectomy, 3.6% developed local recurrence, requiring subsequent complete transplant nephrectomy. During a mean follow-up of 3.12 years, 9 patients were deceased, of which 2 were cancer-specific mortalities.
Mast cells are required for phototolerance induction and scratching abatement (2015)

Dermal mast cells protect the skin from inflammatory effects of ultraviolet (UV) radiation and are required for UV-induced immune suppression. We sought to determine a potential mechanistic role of mast cells in reducing the sensitivity to UV radiation (i.e. phototolerance induction) through photohardening. We administered single UV exposures as well as a chronic UV irradiation regime to mast cell-deficient Kit(W-Sh/W-Sh) mice and their controls. The chronic irradiation protocol was similar to that given for prophylaxis in certain photodermatoses in humans. Compared to controls, UV-exposed Kit(W-Sh/W-Sh) mice were more susceptible to epidermal hyperplasia and dermal oedema which was linked to blood vessel dilation. Unexpectedly, Kit(W-Sh/W-Sh) mice exhibited an excessive scratching behaviour following broadband UVB plus UVA or solar simulated UV irradiation at doses far below their minimal skin-swelling dose. Protection from this UV-induced scratching phenotype was dependent on mast cells, as engraftment of bone marrow-derived cultured mast cells abated it entirely. Kit(W-Sh/W-Sh) mice were entirely resistant to phototolerance induction by photohardening treatment. Compared to controls, these mice also showed reduced numbers of regulatory T cells and neutrophils in the skin 24 h after UV irradiation. While it is well known that mast cell-deficient mice are resistant to UV-induced immune suppression, we have discovered that they are prone to develop photo-itch and are more susceptible to UV-induced epidermal hyperplasia and skin oedema.
Activity-dependent regulation of prestin expression in mouse outer hair cells (2015)

Prestin is a membrane protein necessary for outer hair cell (OHC) electromotility and normal hearing. Its regulatory mechanisms are unknown. Several mouse models of hearing loss demonstrate increased prestin, inspiring us to investigate how hearing loss might feedback onto OHCs. To test whether centrally mediated feedback regulates prestin, we developed a novel model of inner hair cell loss. Injection of diphtheria toxin (DT) into adult CBA mice produced significant loss of inner hair cells without affecting OHCs. Thus, DT-injected mice were deaf because they had no afferent auditory input despite OHCs continuing to receive normal auditory mechanical stimulation and having normal function. Patch-clamp experiments demonstrated no change in OHC prestin, indicating that loss of information transfer centrally did not alter prestin expression. To test whether local mechanical feedback regulates prestin, we used Tecta(C1509G) mice, where the tectorial membrane is malformed and only some OHCs are stimulated. OHCs connected to the tectorial membrane had normal prestin levels, whereas OHCs not connected to the tectorial membrane had elevated prestin levels, supporting an activity-dependent model. To test whether the endocochlear potential was necessary for prestin regulation, we studied Tecta(C1509G) mice at different developmental ages. OHCs not connected to the tectorial membrane had lower than normal prestin levels before the onset of the endocochlear potential and higher than normal prestin levels after the onset of the endocochlear potential. Taken together, these data indicate that OHC prestin levels are regulated through local feedback that requires mechanoelectrical transduction currents. This adaptation may serve to compensate for variations in the local mechanical environment.
Hypercholesterolemia potentiates aortic endothelial response to inhaled diesel exhaust (2011)

Background: Inhalation of diesel exhaust induces vascular effects including impaired endothelial function and increased atherosclerosis.Objective: To examine the in vivo effects of subchronic diesel exhaust exposure on endothelial cell transcriptional responses in the presence of hypercholesterolemia.Methods: ApoE (−/−) and ApoE (+/+) mice inhaled diesel exhaust diluted to particulate matter levels of 300 or 1000 μg/m3 vs. filtered air. After 30 days, endothelial cells were harvested from dispersed aortic cells by fluorescent-activated cell sorting (FACS). Relative mRNA abundance was evaluated by microarray analysis to measure strain-specific transcriptional responses in mice exposed to dilute diesel exhaust vs. filtered air.Results: Forty-nine transcripts were significantly dysregulated by >2.8-fold in the endothelium of ApoE (−/−) mice receiving diesel exhaust at 300 or 1000 μg/m3. These included transcripts with roles in plasminogen activation, endothelial permeability, inflammation, genomic stability, and atherosclerosis; similar responses were not observed in ApoE (+/+) mice.Conclusions: The potentiation of diesel exhaust-related endothelial gene regulation by hypercholesterolemia helps to explain air pollution-induced vascular effects in animals and humans. The observed regulated transcripts implicate pathways important in the acceleration of atherosclerosis by air pollution.
Regulation of CD44v6-containing isoforms during proliferation of normal and malignant epithelial cells. (1997)

CD44 is a family of molecules involved in cell-cell and cell-matrix interactions. Various isoforms of CD44 arise by insertion of one or more of the variant exons into the common backbone shared by all forms of CD44. In this work, we studied the expression of CD44 and exon v6-containing CD44 isoforms (CD44v6) in several nonmalignant and malignant conditions and the possibilities for regulating the expression of CD44v6. In primary squamocellular carcinomas of the head and neck, CD44 and CD44v6 were down-regulated in poorly differentiated tumors, whereas these molecules were uniformly expressed in the normal squamocellular epithelium, in proliferating skin diseases, and in nonmalignant tumors. When CD44v6 expression of original tumors and that of squamocellular carcinoma cell lines derived from them were compared, no CD44v6 up-regulation could be observed on in vitro growing cells. Moreover, several regulators were unable to up-regulate CD44v6 expression on cultured cell lines in vitro. When the same cell lines formed tumors after s.c. injection into severe combined immunodeficient mice, some of them up-regulated their CD44v6 expression. These data suggest that cell lines at certain differentiation stages can be induced to express CD44v6. Our results further indicate that CD44v6 positivity cannot be used as a universal indicator of tumor metastasis. Instead, the down-regulation of CD44v6 in squamocellular tumors is a sign of malignant transformation of the epithelium.
L'industrialisation contemporaine des Pays-Bas (1980)

Les années 1945-1975 sont marquées, aux Pays-Bas, par la priorité absolue accordée au développement des activités industrielles. L'ampleur des mutations qui en résultent, tant au niveau de l'économie nationale qu'à l'échelle des régions, est telle que les Pays-Bas offrent alors l'exemple, assez original, d'un pays développé en cours d'industrialisation. L'accent est mis sûr l'industrialisation des régions périphériques, celles qui font l'objet des politiques de stimulation et de restructuration, politiques étroitement liées à l'aménagement du territoire. L'objectif majeur de la recherche développée ici est de confronter l'action territoriale des pouvoirs publics, la stratégie spatiale des grandes entreprises industrielles, la nature des problèmes à résoudre dans les diverses régions. L'industrialisation régionale se heurte à bien des difficultés : les effets de l'ouverture du marché néerlandais, l'insuffisante efficacité des aides publiques, une certaine discordance entre les politiques néerlandaises et les orientations proposées par la Commission des Communautés européennes, la mise en pratique d'une stratégie spatiale très sélective de la part des grandes entreprises. D'abord surtout quantitative, l'industrialisation est de plus en plus qualitative, ce qui accroît les difficultés des régions périphériques. A partir des années 1972-1974, les activités tertiaires prennent le relais de l'industrie comme moteur principal du développement régional.
Design method of MTCMOS power switch for low-voltage high-speed LSIs (1999)

The design of the power switch which turns on and off the power supply to the logic gates is essential to low-voltage high-speed circuit techniques such as multi-threshold voltage CMOS (MTCMOS). This is because this switch influences the speed, area, and power of a low-voltage LSI. This paper describes the influences of the power switch on the circuit performance in detail, and proposes a systematic method for designing a power switch which takes them into consideration for the first time. The main feature of this method, called the average-current method, is the use of the average current consumed in an LSI to determine the power-switch size. This makes it easy for designers to determine the minimum size of the power-switch needed to satisfy the required speed, which results in minimizing the area penalty and the standby power. Useful analytical formula and the practical determination flow are also described. Measurement of an actual 0.25 /spl mu/m MTCMOS/SIMOX 290-Kgate LSI operating at 1 V confirmed the effectiveness of this method. This method estimated well the required power-switch width, and as a result it reduced the area penalty and standby current by about 80% compared to the conventional design scheme.
Enhancing performance with multisensory cues in a realistic target discrimination task (2022)

Making decisions is an important aspect of people's lives. Decisions can be highly critical in nature, with mistakes possibly resulting in extremely adverse consequences. Yet, such decisions have often to be made within a very short period of time and with limited information. This can result in decreased accuracy and efficiency. In this paper, we explore the possibility of increasing speed and accuracy of users engaged in the discrimination of realistic targets presented for a very short time, in the presence of unimodal or bimodal cues. More specifically, we present results from an experiment where users were asked to discriminate between targets rapidly appearing in an indoor environment. Unimodal (auditory) or bimodal (audio-visual) cues could shortly precede the target stimulus, warning the users about its location. Our findings show that, when used to facilitate perceptual decision under time pressure, and in condition of limited information in real-world scenarios, spoken cues can be effective in boosting performance (accuracy, reaction times or both), and even more so when presented in bimodal form. However, we also found that cue timing plays a critical role and, if the cue-stimulus interval is too short, cues may offer no advantage. In a post-hoc analysis of our data, we also show that congruency between the response location and both the target location and the cues, can interfere with the speed and accuracy in the task. These effects should be taken in consideration, particularly when investigating performance in realistic tasks.
Synthesis, Spectroscopy and X-ray Crystallography Structure of Pyridine 4-Carbaldehyde Semicarbazone Schiff Base Ligand (2020)

In this work, pyridine 4-carbaldehye semicarbazone Schiff base ligand (HL) was synthesized with condention of pyridine 4-carbaldehyde and semicarbazide hydrochloride in reflux method. The HL was characterized using the CHN elemental analysis, FT-IR, UV-Vis, and 1H NMR spectroscopy. The single crystals of HL prepared and used for the X-ray crystallography. Single-crystal X-ray diffraction revealed that, HL crystallized in a triclinic system with the space group P-1. The FT-IR spectra and X-ray crystallography results suggested that the HL ligand is in keto form.