gebhart/patrepeval huggingface dataset:
Abstract LB-189: Novel bone morphogenetic protein receptor inhibitor JL5 suppresses tumor cell survival signaling and induces regression of human lung cancer (2018)

Abstract Purpose: Studies have shown that bone morphogenetic protein (BMP) signaling is aberrantly expressed in lung and other carcinoma leading to pro-oncogenic effects on tumor growth. The BMP receptor inhibitor DMH2 induces death of lung cancer cells through the downregulation of anti-apoptotic proteins XIAP, TAK1, and Id1-Id3. Since DMH2 does not downregulate BMP signaling in vivo because of metabolic instability and poor pharmacokinetics better BMP inhibitors are needed. Experimental Design: Here, we identified a site of metabolic instability of DMH2 and designed a novel BMP receptor inhibitor, JL5. We examined the effects of JL5 to downregulate BMP signaling and induce cell death of lung cancer cells in vitro and in vivo. We also queried the The Cancer Genome Atlas (TCGA) to assess if genetic alterations in lung cancer would affect drug targetability of the BMP receptors. Results: We show that JL5 has improved pharmacokinetic profile compared to DMH2. JL5 suppresses BMP signaling in lung cancer cells in vitro and in tumor xenografts. Moreover, we demonstrate JL5-induced tumor cell death and tumor regression in xenograft mouse models without immune cells and humanized with adoptively transferred human immune cells. In humanized mice, JL5 additionally induces the infiltration of immune cells within the tumor microenvironment. The TCBA database analysis suggests that genetic alterations in the BMP signaling cascade will not limit targeting with small molecule inhibitors. Conclusion: Our studies show that the BMP signaling pathway is targetable and BMP receptor inhibitors should be developed as a therapeutic to treat lung and other cancer patients. Citation Format: Jenna H. Newman, Rachel E. NeMoyer, David Augeri, Jyoti Malhotra, Elaine Langenfeld, Charles B. Chesson, Micheal J. Lee, Saeed Tarabichi, Sachin R. Jhawar, Praveen K. Bommareddy, Sh'rae Marshall, Evita T. Sadimin, John E. Kerrigan, Michael Goedken, Christine Minerowicz, Salma K. Jabbour, Shengguo Li, Natalie Dobias, Mary O. Carayannopolous, Andrew Zloza, John Langenfeld. Novel bone morphogenetic protein receptor inhibitor JL5 suppresses tumor cell survival signaling and induces regression of human lung cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr LB-189.
Effect of Surfactant Concentration and Hydrophobicity on the Ordering of Water at a Silica Surface (2021)

The performance of nonionic surfactants is mediated by the interfacial interactions at the solid-liquid interface. Here we applied sum frequency generation (SFG) vibrational spectroscopy to probe the molecular structure of the silica-nonionic surfactant solution interface in situ, supplemented by quartz crystal microbalance with dissipation monitoring (QCM-D) and molecular dynamics (MD) simulations. The combined studies elucidated the effects of nonionic surfactant solution concentration, surfactant composition, and rinsing on the silica-surfactant solution interfacial structure. The nonionic surfactants studied include ethylene-oxide (EO) and butylene oxide (BO) components with different ratios. It was found that the CH groups of the surfactants at the silica-surfactant solution interfaces are disordered, but the interfacial water molecules are ordered, generating strong SFG OH signals. Solutions with higher concentrations of surfactant lead to a slightly higher amount of adsorbed surfactant at the silica interface, resulting in more water molecules being ordered at the interface, or a higher ordering of water molecules at the interface, or both. MD simulation results indicated that the nonionic surface molecules preferentially adsorb onto silanol sites on silica. A surfactant with a higher EO/BO ratio leads to more water molecules being ordered and a higher degree of ordering of water molecules at the silica-surfactant solution interface, exhibiting stronger SFG OH signal, although less material is adsorbed according to the QCM-D data. A thin layer of surfactants remained on the silica surface after multiple water rinses. To the best of our knowledge, this is the first time the combined approaches of SFG, QCM-D and MD simulation techniques have been applied to study nonionic surfactants at the silica-solution interface, which enhances our understanding on the interfacial interactions between nonionic surfactants, water and silica. The knowledge obtained from this study can be helpful to design the optimal surfactant concentration and composition for future applications.
Portable Ambulatory Electrocardiogram Monitoring System Based on Bluetooth (2009)

According to the waveform distortion problem existed in the portable ambulatory electrocardiogram (ECG) monitoring system and analyzing the wireless Bluetooth technology working principle used in portable ECG monitoring system, the paper proposes an overall design idea of portable ambulatory ECG monitoring system based on Bluetooth and implementation program of system hardware and software . It can be seen from the analysis and contrast of performance test in laboratory and function test in hospital that the normal ECG of the person obtained by ECG monitor of a hospital can be in conformity to that obtained by the system in a rate as high as 99%. This system can realize the effective real-time diagnosis and monitoring. And it can make the connection with Internet a possibility. Thus the remote wireless monitoring comes true. This system can be applied widely.
Replaceable Hinge Detailing for Bridge Columns (1999)

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Normal faulting and mass movement during ridge subduction inferred from porosity transition and zeolitization in the Costa Rica subduction zone (2017)

Abstract Subduction of the buoyant Cocos Ridge offshore the Osa Peninsula, Costa Rica substantially affects the upper plate structure through a variety of processes, including outer forearc uplift, erosion, and focused fluid flow. To investigate the nature of a major seismic reflector (MSR) developed between slope sediments (late Pliocene‐late Pleistocene silty clay) and underlying higher velocity upper plate materials (late Pliocene‐early Pleistocene clayey siltstone), we infer possible mechanisms of sediment removal by examining the consolidation state, microstructure, and zeolite assemblages of sediments recovered from Integrated Ocean Drilling Program Expedition 344 Site U1380. Formation of Ca‐type zeolites, laumontite and heulandite, inferred to form in the presence of Ca‐rich fluids, has caused porosity reduction. We adjust measured porosity values for these pore‐filling zeolites and evaluated the new porosity profile to estimate how much material was removed at the MSR. Based on the composite porosity‐depth curve, we infer the past burial depth of the sediments directly below the MSR. The corrected and uncorrected porosity‐depth curves yield values of 800 ± 70 m and 900 ± 70 m, respectively. We argue that deposition and removal of this entire estimated thickness in 0.49 Ma would require unrealistically large sedimentation rates and suggest that normal faulting at the MSR must contribute. The porosity offset could be explained with maximum 250 ± 70 m of normal fault throw, or 350 ± 70 m if the porosity were not corrected. The porosity correction significantly reduces the amount of sediment removal needed for the combination of mass movement and normal faulting that characterize the slope in this margin.
Plasma LH Patterns after LHRH Infusion in Long-Term, Unanesthetized Ovariectomized Rats (1980)

Experiments were conducted in vivo to investigate further if the control of the pulsatile plasma LH phenomenon in ovariectomized (OVX) rats is located in the brain or in the adenohypophysis. Luteinizing hormone releasing hormone (LHRH) was infused at a constant rate (2--100 ng/h) through an indwelling venous cannula in unanesthetized, unrestrained OVX rats. Blood samples were collected at 5-min intervals through a second venous cannula prior to and during LHRH infusion for subsequent radioimmunoassay of plasma LH. LHRH infusion at 12.5, 50 and 100 ng/h did not interfere with the magnitude or the periodicity of LH pulses in plasma but the range within which plasma LH fluctuated was elevated. Phenobarbital (75 mg/kg BW; i.p.) blocked the pulsatile plasma LH and maintained the plasma LH nearly constant at reduced levels. Pulse i.v. injections of LHRH but not constant rate i.v. infusions restored pulsatile LH patterns in phenobarbital-treated OVX rats. The results are consistent with the view that pulsatile LHRH release is responsible for the pulsatile nature of plasma LH in OVX rats. The results do not support the concepts of a short-loop feedback of LH or an ultra-short-loop feedback of LHRH on LH secretion at least on an acute basis.
Discussion of “Reservoir Flood Season Segmentation and Optimal Operation of Flood-Limiting Water Levels” by Haiyan Jiang, Zhongbo Yu, and Chongxun Mo (2015)

Omid Bozorg-Haddad; Melika Mani; and Hugo A. Loaiciga, F.ASCE Associate Professor, Dept. of Irrigation and Reclamation Engineering, Faculty of Agricultural Engineering and Technology, College of Agriculture and Natural Resources, Univ. of Tehran, Karaj, 3158777871 Tehran, Iran (corresponding author). E-mail: OBHaddad@ut.ac.ir Dept. of Irrigation and Reclamation Engineering, Faculty of Agricultural Engineering and Technology, College of Agriculture and Natural Resources, Univ. of Tehran, Karaj, 3158777871 Tehran, Iran. E-mail: Melika.Mani@ut.ac.ir Professor, Dept. of Geography, Univ. of California, Santa Barbara, CA 93106. E-mail: Hugo.Loaiciga@ucsb.edu
Bio-derived materials as a green route for precious & critical metal recovery and re-use (2015)

Overview of research in critical and precious metal recovery using biosorption, application to real-life wastes and uses of the metal-loaded materials.
Childhood Uveitis (2020)

Childhood uveitis is an ophthalmological challenge, since on the one hand it often remains asymptomatic and difficult to detect, and on the other hand it often has a chronic course and is associated with a high risk of complications threatening the vision. The most important risk factors for childhood uveitis are underlying rheumatic diseases; recommendations for ophthalmological monitoring have been developed together with paediatric rheumatologists. Intermediate and posterior uveitis are rare in children. The therapy must effectively control inflammation and at the same time cause only minimal side effects. Since steroids in particular cause side effects frequently, an immunosuppressive therapy must be initiated early in an interdisciplinary cooperation with paediatric rheumatologists and parents with the goal of minimising steroids.
Miniature endoscopes in otorhinolaryngologic applications (1998)

SummaryProgressive miniaturization of rigid and flexible endoscopes enables the practising otorhinolaryngologist (head and neck surgeon) to visually inspect regions of the upper respiratory tract that could never have been inspected directly before, or had only been accessible for direct view by massive traumatization of the anatomic surroundings. For the otologist, microendoscopy opens up the possibility of using an endoscope to assess the luminal situation of the Eustachian tube, in order to detect morphological obstructions of this normally collapsed connection between the middle ear compartment and the nasopharynx. The first basic laser surgery on polyps and oedematous soft tissues to restore the essential proper ventilation and drainage of the tympanic cavity have been performed and data about this topic are soon to be published. The ‘mother-baby endoscope’ technique allows us to reach into the nasopharynx and paranasal sinuses via the natural orifices, for a direct visual diagnosis of chronic secretory and polypous rhinosinusitis. Even small recurrences can be treated using minimally invasive techniques by fibre-delivered laser surgery in hidden areas of facial skull cavities. This painless technique is particularly useful in children. The development of ‘sialendoscopy’ i.e. microendoscopy of the salivary glands, is the first procedure to identify the real cause of obstructive disorders of the major salivary glands. Direct visual inspection allows the examiner to differentiate between stenoses, secretion plugs and calculi. In cases of sialolithiasis, laser-induced shock wave lithotripsy (LIL) can be performed by transferring short laser pulses via an inserted fibre onto the surface of the stone to disintegrate it.
Superior Canal Dehiscence Syndrome Associated With the Superior Petrosal Sinus in Pediatric and Adult Patients (2011)

This is the first series of patients who have SCDS due to contact of the SPS with the superior semicircular canal. Exercise and exertion-related symptoms are common in patients who have SCD owing to this cause. Transmastoid superior canal plugging is feasible and successful in treating SCDS in the pediatric patient.
ChemInform Abstract: Structure and Synthesis of a Unique Isonitrile Lipid Isolated from the Marine Mollusk Actinocyclus papillatus. (2011)

Abstract Both enantiomers are prepared and (R)‐I is found to be the natural product actisonitrile.
Experimental Validation of a Reliable Palmprint Recognition System Based on 2D Ultrasound Images (2019)

Ultrasound has been trialed in biometric recognition systems for many years, and at present different types of ultrasound fingerprint readers are being produced and integrated in portable devices. An important merit of the ultrasound is its ability to image the internal structure of the hand, which can guarantee improved recognition rates and resistance to spoofing attacks. In addition, ambient noise like changes of illumination, humidity, or temperature, as well as oil or ink stains on the skin do not affect the ultrasound image. In this work, a palmprint recognition system based on ultrasound images is proposed and experimentally validated. The system uses a gel pad to obtain acoustic coupling between the ultrasound probe and the user’s hand. The collected volumetric image is processed to extract 2D palmprints at various under-skin depths. Features are extracted from one of these 2D palmprints using a line-based procedure. Recognition performances of the proposed system were evaluated by performing both verification and identification experiments on a home-made database containing 281 samples collected from 32 different volunteers. An equal error rate of 0.38% and an identification rate of 100% were achieved. These results are very satisfactory, even if obtained with a relatively small database. A discussion on the causes of bad acquisitions is also presented, and a possible solution to further optimize the acquisition system is suggested.
Regularized Fourier Ptychography Using an Online Plug-and-play Algorithm (2019)

The plug-and-play priors (PnP) framework has been recently shown to achieve state-of-the-art results in regularized image reconstruction by leveraging a sophisticated denoiser within an iterative algorithm. In this paper, we propose a new online PnP algorithm for Fourier ptychographic microscopy (FPM) based on the accelerated proximal gradient method (APGM). Specifically, the proposed algorithm uses only a subset of measurements, which makes it scalable to a large set of measurements. We validate the algorithm by showing that it can lead to significant performance gains on both simulated and experimental data.
High-Dimensional Graphical Model Selection Using $\ell_1$-Regularized Logistic Regression (2008)

We consider the problem of estimating the graph structure associated with a discrete Markov random field. We describe a method based on $\ell_1$-regularized logistic regression, in which the neighborhood of any given node is estimated by performing logistic regression subject to an $\ell_1$-constraint. Our framework applies to the high-dimensional setting, in which both the number of nodes $p$ and maximum neighborhood sizes $d$ are allowed to grow as a function of the number of observations $n$. Our main results provide sufficient conditions on the triple $(n, p, d)$ for the method to succeed in consistently estimating the neighborhood of every node in the graph simultaneously. Under certain assumptions on the population Fisher information matrix, we prove that consistent neighborhood selection can be obtained for sample sizes $n = Ω(d^3 \log p)$, with the error decaying as $\order(\exp(-C n/d^3))$ for some constant $C$. If these same assumptions are imposed directly on the sample matrices, we show that $n = Ω(d^2 \log p)$ samples are sufficient.
Expedient synthesis of conjugated triynes via alkyne metathesis (2020)

The first synthesis of conjugated triynes by molybdenum-catalysed alkyne metathesis is reported. Strategic to the success of this approach is the utilization of sterically-hindered diynes that allowed for the site-selective alkyne metathesis to produce the desired conjugated triyne products. The steric hindrance of the alkyne moiety was found to be crucial in preventing the formation of diyne byproducts. This novel synthetic strategy was amenable to self- and cross-metathesis providing straightforward access to the corresponding symmetrical and dissymmetrical triynes with high selectivity.
Selecting Targets for Tumor Imaging: An Overview of Cancer-Associated Membrane Proteins (2016)

Tumor targeting is a booming business: The global therapeutic monoclonal antibody market accounted for more than $78 billion in 2012 and is expanding exponentially. Tumors can be targeted with an extensive arsenal of monoclonal antibodies, ligand proteins, peptides, RNAs, and small molecules. In addition to therapeutic targeting, some of these compounds can also be applied for tumor visualization before or during surgery, after conjugation with radionuclides and/or near-infrared fluorescent dyes. The majority of these tumor-targeting compounds are directed against cell membrane-bound proteins. Various categories of targetable membrane-bound proteins, such as anchoring proteins, receptors, enzymes, and transporter proteins, exist. The functions and biological characteristics of these proteins determine their location and distribution on the cell membrane, making them more, or less, accessible, and therefore, it is important to understand these features. In this review, we evaluate the characteristics of cancer-associated membrane proteins and discuss their overall usability for cancer targeting, especially focusing on imaging applications.
Development and Testing of a Plastic Smoke Generation Source (2001)

Niemand kann in die Zukunft blicken. Das gilt auch für die Zukunft der Beton- und Fertigteilindustrie. Aussichten und Erwartungen können allerdings aufgezeigt und erörtert werden. Beispielsweise im nächsten Jahr, im Rahmen eines interessanten Kongresses in Amsterdam und der parallel dazu durchgeführten Fachausstellung; ein Ereignis, das traditionell all drei Jahre stattfindet – diesmal vom 11. bis 14. Mai 2005 in den Niederlanden.
Hierarchical Assembly of Peptoid‐Based Cylindrical Micelles Exhibiting Efficient Resonance Energy Transfer in Aqueous Solution (2019)

Abstract Herein we show that by appending bulky β‐cyclodextrin (CD) groups onto sheet‐forming peptoids, we obtain cylindrical micelles that further assembly into membranes and intertwined ribbons on substrates in aqueous solution, depending on the choice of solution and substrate conditions. In situ atomic force microscopy (AFM) shows that micelle assembly occurs in two steps, starting with “precursor” particles that transform into worm‐like micelles, which extend and coalesce to form the higher order structures with a rate and a degree of cooperativity dependent on pH and Ca 2+ concentration. After co‐assembly with hydrophobic 4‐(2‐hydroxyethylamino)‐7‐nitro‐2,1,3‐benzoxadiazole (NBD) donors that occupy the hydrophobic core, followed by exposure to hydrophilic Rhodamine B as acceptors that insert into cyclodextrin, the micelles exhibit highly efficient Förster resonance energy transfer efficiency in aqueous solution, thereby mimicking natural light harvesting systems.
Reduction of Pain Episodes and Prothrombotic Activity in Sickle Cell Disease by Dietary n-3 Fatty Acids (2001)

The effects of dietary n-3 fatty acids (n-3FAs) on the frequency of pain episodes and ex vivo blood tests of thrombosis have been evaluated in patients with sickle cell disease (SCD) utilizing a double-blind, olive oil-controlled clinical trial. Dietary n-3FA therapy (0.1 g/kg/d) was provided as menhaden fish oil (0.25 g/kg/d) containing 12% eicosapentaenoic acid (EPA), and 18% docosahexaenoic acid (DHA). Within 1 month dietary n-3FAs exchanged with n-6FAs in plasma and erythrocyte membrane phospholipids (p <0.01 in all cases). Treatment with dietary n-3FAs for 1 year reduced the frequency of pain episodes requiring presentation to the hospital from 7.8 events during the preceding year to 3.8 events/year (p <0.01; n = 5). By contrast, subjects receiving control dietary olive oil (n = 5) experienced 7.1 pain events/year, compared to 7.6 during the previous year (p >0.4). The reduction in episodes in n-3FA-treated subjects was also significant when compared to control subjects (p <0.01). Dietary n-3FA therapy was not associated with hemorrhagic, gastrointestinal or other adverse effects. Compared to 10 asymptomatic African-American controls, sickle cell subjects demonstrated significantly increased pretreatment: 1) flow cytometric expression of platelet membrane P-selectin (CD62p; p <0.01) and annexin V binding sites (p = 0.02); 2) plasma levels of platelet-specific secretory proteins platelet factor 4 (PF4) and beta-thromboglobulin (betaTG) (p <0.01 in both cases); 3) plasma products of thrombin generation, prothrombin fragment 1.2 (F1.2) and thrombin:antithrombin (TAT) complex (p <0.01 in both cases); and 4) plasma levels of thrombolytic products, D-dimer and plasmin:antiplasmin (PAP) complex (p <0.01 in both cases). Treatment with dietary n-3FAs concurrently decreased plasma levels of F1.2, D-dimer, and PAP (p <0.05, compared to olive oil controls), implying that the reduction in pain events was related to n-3FA-dependent inhibition of thrombosis. We conclude that dietary n-3FAs reduce the frequency of pain episodes perhaps by reducing prothrombotic activity in sickle cell disease.