gebhart/patrepeval huggingface dataset:
Acute Myeloproliferative Disorder Following Long-Term Chlorambucil Therapy (1974)

Potent cytotoxic agents whose initial use was confined to the treatment of malignant neoplasms are now being administered in the therapy of many non-neoplastic conditions. The use of alkylating agents in diseases such as rheumatoid arthritis,<sup>1-4</sup>systemic lupus erythematosus,<sup>5-7</sup>hemolytic anemia,<sup>8</sup>and glomerulonephritis<sup>9</sup>demands a surveillance for their possible long-term toxic effects. This report concerns two patients with malignant lymphoma who were treated with chlorambucil for periods of four and seven years. They died of acute myelogenous leukemia (AML) despite excellent response of their original disease to therapy. <h3>Patient Summaries</h3><h3>Patient 1.</h3> —A 53-year-old white woman had an eight-year history of nodular lymphoma, poorly differentiated lymphocytic type (Fig 1, top left and right). Generalized adenopathy was treated with chlorambucil at 6 mg/day from 1962 until 1969. In November 1969, the therapy with chlorambucil was discontinued because of a falling white blood cell (WBC) count and the
Narrow‐gap ferromagnetic semiconductors (In,Mn)Sb on GaAs (001): growth and properties (2009)

Abstract Narrow‐gap (In,Mn)Sb layers, which offer prospects for infrared spin‐photonics, were grown on GaAs (001) substrates using a Riber Compact 21T MBE system and a Veeco valved cracker cell for Sb. Samples consisting 0.4 μm (In,Mn)Sb/GaAs with different Mn content in the range of 1% were examined in this study in respect of their structural, magnetotransport and magnetization properties. It is found that Mn decreases the lattice constant as well as the degree of relaxation of (In,Mn)Sb films. The hole concentration increases with increasing Mn concentration resulting increased acceptor concentration and decreased resistivity. The magnetoresistance is found to be sensitive to the Mn concentration. The temperature‐dependent resistivity data at lower than 30 K show an increased resistivity with decreasing temperature, suggesting the insulating behavior of the samples. In addition, magnetization measurements reveal distinct hysteresis loops, indicating the ferromagnetic properties. The measured saturation magnetization values of the films are found to be dependent on Mn concentration. The Curie temperature is estimated to be below 50 K. (© 2009 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
Detect and avoid system based on multi sensor fusion for UAV (2018)

With the rapid growth of the personal drone market, manufacturers of unmanned aerial vehicles(UAV) mainly used in the existing military field are expanding its application in various fields such as leisure, industrial, and public as well. In addition, the autonomous flight of UAV is being developed through combination with various sensors and signal processing technologies. Obstacle detect and avoidance is the most important function to ensure safety of autonomous flight mode. In this paper, we propose an obstacle detect and avoid technique that combines a 2D LiDAR with a stereo camera for safe navigation in autonomous flight of a multi-copter UAV.
Návrhy opatření na snížení kriminality ve městě Holešově (2017)

This thesis deals with crime and crime prevention with a focus on Holesov city territory. The aim of the thesis is to analyze the current state of crime and crime prevention plan, their analysis and the subsequent proposal of measures. The theoretical part of the thesis describes the concepts of criminality, such as its indicators and types, and the criminality factors that affect it in various areas. It further defines the concepts of crime prevention and describes the system of crime prevention. In the practical part, the thesis focuses on the analysis of the current state of criminality in the Holesov city and the analysis of the city's crime prevention plan. On the basis of this analysis, the last part proposes measures to reduce crime in the city of Holesov, including their impact on the city budget.
Determination of Anti-Malignin Antibody and Malignin in 1,026 Cancer Patients and Controls: Relation of Antibody to Survival (1982)

No AccessJournal of Urology1 Dec 1982Determination of Anti-Malignin Antibody and Malignin in 1,026 Cancer Patients and Controls: Relation of Antibody to Survival S. Bogoch, E.S. Bogoch, C.A. Fager, J.H. Harris, J.L. Ambrus, W.E. Lux, and J.A. Ransohoff S. BogochS. Bogoch More articles by this author , E.S. BogochE.S. Bogoch More articles by this author , C.A. FagerC.A. Fager More articles by this author , J.H. HarrisJ.H. Harris More articles by this author , J.L. AmbrusJ.L. Ambrus More articles by this author , W.E. LuxW.E. Lux More articles by this author , and J.A. RansohoffJ.A. Ransohoff More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)53546-6AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Determination of Anti-Malignin Antibody and Malignin in 1,026 Cancer Patients and Controls: Relation of Antibody to Survival." The Journal of Urology, 128(6), p. 1418 © 1982 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 128Issue 6December 1982Page: 1418 Advertisement Copyright & Permissions© 1982 by The American Urological Association Education and Research, Inc.MetricsAuthor Information S. Bogoch More articles by this author E.S. Bogoch More articles by this author C.A. Fager More articles by this author J.H. Harris More articles by this author J.L. Ambrus More articles by this author W.E. Lux More articles by this author J.A. Ransohoff More articles by this author Expand All Advertisement PDF DownloadLoading ...
Controlled Release of LHRH Agonist, Leuprolide Acetate, from Microcapsules: Serum Drug Level Profiles and Pharmacological Effects in Animals (1989)

The pharmacokinetic behaviour of leuprolide acetate from a controlled release parenteral dosage form has been studied in rats and dogs. The release of the drug in rats after a single subcutaneous injection exhibited pseudo-zero-order kinetics for one month in doses ranging from 0.0135 to 1.35 mg/rat; the release rate at a dose of 1.35 mg/rat was 2.8% of dose/day; after intramuscular injection the response was similar. In rats, the serum leuprolide acetate levels increased sharply immediately after injection by either route as a consequence of the initial release of the drug; subsequently, the levels attained a plateau for two weeks. The serum level profiles in dogs showed essentially the same pattern as those in rats. When the dosage form was injected into rats, the serum testosterone level (a pharmacological index) sharply peaked, abruptly decreased to below the normal level, and then was sustained at a suppressed level for over six weeks at a dose of 1.35 mg/rat (equivalent to 3 mg kg-1) and higher, while the serum testosterone level after an injection of 0.0135 and 0.135 mg/rat was not sufficiently suppressed. The profiles in dogs showed essentially the same pattern as those in rats. With multiple administrations (once every 4 weeks), serum testosterone levels in dogs did not show any sharp rise after the second and third injections. Changes in rat reproductive organ weights agreed well with the serum testosterone profile in the suppression. The results demonstrate that this dosage form releases the drug at a constant rate for one month and has a long-acting potency.
PULSAR open-label extension: interim results from a phase 2 study of the efficacy and safety of sotatercept when added to standard of care for the treatment of pulmonary arterial hypertension (PAH) (2021)

<b>Background:</b> New therapies are needed to target vascular remodeling in PAH. Sotatercept is a novel first-in-class fusion protein that acts by rebalancing deficient BMPR2 signaling. <b>Aims and Objectives:</b> To determine the safety and efficacy of sotatercept for the treatment of PAH. <b>Methods:</b> 106 WHO Group 1 PAH patients (pts) were enrolled: WHO functional class (FC)II-III; baseline pulmonary vascular resistance&nbsp;of ≥5 Wood units; 6MWD of 150-550m. Sotatercept (0.3mg/kg or 0.7mg/kg)&nbsp;was added to standard of care (SOC) for a 24-week (wk) double-blind, placebo-controlled treatment period. The extension&nbsp;period is ongoing&nbsp;in which&nbsp;sotatercept-treated pts maintain&nbsp;their&nbsp;current&nbsp;dose level, and placebo-treated pts&nbsp;were&nbsp;re-randomized to&nbsp;0.3mg/kg or 0.7mg/kg&nbsp;sotatercept. <b>Results:</b> Continuation of sotatercept treatment for up to 48 wks maintained the improvements observed in 6MWD, NT-proBNP, and change in WHO FC at 24 weeks versus baseline. Pts re-randomized from placebo to sotatercept showed improvements in 6MWD, NT-proBNP, and change in WHO FC at 48 wks compared to 24 wks and baseline. Cumulatively during the trial, 30/106(28.3%) patients reported serious treatment-emergent adverse events (TEAEs), 9(8.5%) TEAEs led to study discontinuation, and 2(1.9%) TEAEs led to death. <b>Conclusions:</b> Continued sotatercept treatment maintained clinical efficacy across multiple study endpoints for up to 48 wks. Importantly, placebo assignment did not affect the ability to respond after 24 wks. Safety was consistent with previous reports in PAH and other pt populations.
Surgical Repair of Leaking Filtering Blebs Using Two Different Techniques (2016)

Purpose: To report the outcomes of two different surgical techniques for the repair of late onset bleb leakage following trabeculectomy. Methods: This retrospective study includes 21 eyes of 20 patients with prior trabeculectomy and late-onset bleb leaks; 14 eyes underwent excision of the filtering bleb together with conjunctival advancement while in the other 7 eyes the bleb was retained but de-epithelialized before conjunctival advancement. Success was defined as resolution of leakage with no need for additional glaucoma surgery together with intraocular pressure (IOP) of 5-21 mmHg. Complete and qualified success was considered when the above mentioned was achieved without or with glaucoma medications, respectively. Results: Mean duration of follow-up was 20.3±14.4 months. No significant difference was observed between the two groups in terms of complete, qualified and overall success rates (P&amp;gt;0.05), however more antiglaucoma medications were necessary in the bleb excision group (P=0.02). Conclusions: Both surgical techniques of bleb repair were comparably effective, however the bleb de-epithelialization technique was associated with less need for glaucoma medications after the procedure.
Influence of Temperature and Pore Pressure on Geomechanical Behavior of Methane Hydrate-Bearing Sand (2022)

Geomechanical behavior of methane hydrate-bearing sediment (MHBS) plays a major role in evaluation of the stability of a hydrate reservoir. A series of triaxial compression tests were conducted on MHBS to study the influence of temperature and pore pressure conditions on its mechanical behaviors. The experimental results show that temperature and pore pressure have a significant effect on the stress–strain curve, stiffness, and strength of MHBS. As temperature decreases and/or pore pressure increases, the stress–strain curve manifests an enhanced strain-softening characteristic, stiffness, and strength. Furthermore, MHBS cohesion also tends to exhibit a significant increase, but its internal friction angle almost remains constant with decreasing temperature and/or increasing pore pressure. These findings imply that the change in temperature and pore pressure affects the strength of MHBS, which occurs predominately due to change in its cohesiveness. To describe these impacts, a phase state parameter is introduced to characterize the temperature and pore pressure conditions. Meanwhile, three empirical formulas for relating the secant modulus, strength and cohesiveness to phase state parameter are presented. Good agreement between simulation and measured data indicates that the phase state parameter can effectively describe temperature and pore pressure conditions. The proposed empirical formulas are able to address the influences of temperature and pore pressure conditions on geomechanical characteristics of MHBS.
Office of Naval Research Graduate Traineeship Award in Ocean Acoustics for Ankita Deepak Jain (2012)

Abstract : OBJECTIVES A primary goal of this research is to model biological clutter in the continental shelf environments of the ocean. We aim to do this by modeling scattered returns from fish shoals in continental shelf environments using a full field matched filter approach as well as its single frequency approximation. This will help in characterizing clutter and will help distinguish scattered fields of moving targets from stationary background reverberation and submerged targets in sonar data. We aim to develop a unified theory and model for ocean reverberation dependent on seafloor parameters such as density, compressibility and coherence volume. We will use a full field matched filter approach and its time harmonic approximation to model reverberation from volume inhomogeneities. A Monte-Carlo approach based on the parabolic equation will be applied to model acoustic wave propagation in a fluctuating ocean waveguide. We aim at using the model to invert for these parameters and obtain accurate estimates by calibrating modeled returns with data collected during past Ocean Acoustic Waveguide Remote Sensing (OAWRS) experiments in 2003 and 2006 in the New Jersey continental shelf and the Gulf of Maine, respectively. The final goal of this research is to test the hypothesis that inexpensive underwater acoustic measurements can be used to determine the wind speed and classify the destructive power of a hurricane with greater accuracy than standard satellite remote sensing techniques and with at least the same accuracy as hurricane hunting aircraft.
Food Intake and Foraging Energetics of Elk and Mule Deer (1984)

Mark L. Wickstrom, Charles T. Robbins, Thomas A. Hanley, Donald E. Spalinger, Steven M. Parish, Food Intake and Foraging Energetics of Elk and Mule Deer, The Journal of Wildlife Management, Vol. 48, No. 4 (Oct., 1984), pp. 1285-1301
Thermal stability of rare-earth based ultrathin Lu2O3 for high-k dielectrics (2007)

Lu 2 O 3 thin film was deposited on n-type (100) Si substrates using pulsed laser deposition. A k value of 15.95 with an equivalent oxide thickness (EOT) of 1.10nm and a current density of 2.6×10−5A∕cm2 at +1V accumulation bias is achievable for the 4.5nm thick Lu2O3 thin film deposited at room temperature after postdeposition annealing at 600°C in oxygen ambient. Annealing a similar sample at 900°C caused the EOT and leakage current density to increase to 1.68nm and 1×10−4A∕cm2, respectively. High resolution transmission electron microscopy analysis has shown that Lu2O3 film remains amorphous at high temperature annealing at 900°C. An x-ray reflectivity analysis on a separately prepared sample with lower annealing temperature (800°C) suggested a formation of Lu-based silicate layer. It is believed that the formation of low-k silicate layer may have contributed to the observed increase in EOT and the reduction in the k value.
Residual Shuffle-Exchange Networks for Fast Processing of Long Sequences (2021)

Attention is a commonly used mechanism in sequence processing, but it is of O(n^2) complexity which prevents its application to long sequences. The recently introduced neural Shuffle-Exchange network offers a computation-efficient alternative, enabling the modelling of long-range dependencies in O(n log n) time. The model, however, is quite complex, involving a sophisticated gating mechanism derived from the Gated Recurrent Unit. In this paper, we present a simple and lightweight variant of the Shuffle-Exchange network, which is based on a residual network employing GELU and Layer Normalization. The proposed architecture not only scales to longer sequences but also converges faster and provides better accuracy. It surpasses the Shuffle-Exchange network on the LAMBADA language modelling task and achieves state-of-the-art performance on the MusicNet dataset for music transcription while being efficient in the number of parameters. We show how to combine the improved Shuffle-Exchange network with convolutional layers, establishing it as a useful building block in long sequence processing applications.
Gravel Roads and Dust Suppression (2009)

ABSTRACT This review paper deals with the field of dust generation on gravel roads, dust suppressant performance and evaluation techniques. By applying the proper dust suppressant, matching the gravel road condition specific to the site, dust emission can be reduced, thereby providing a healthier ambient air environment, increasing road safety and ride comfort while reducing the need and cost of vehicle repair, road maintenance activities, and aggregate replacement. By applying the proper application rate of the dust suppressant, the cost of annual dust control as well as the environmental impact can be significantly reduced. Suitable measuring techniques for evaluating dust suppressant efficiency will facilitate the choice of the most appropriate dust suppressant and its optimal application rate.
Predicting adsorption properties for ACFs (1996)

Activated carbon fibers (ACFs), and activated carbon granules (ACGs) have been available for about the past 25 and 50 years, respectively. However, selection of the appropriate activated carbon to remove specific contaminants is still very much an empirical process. The problem that exists in creating a more fundamental understanding of these processes is the fact that up to now there has been no direct method for measuring the key parameters. In this paper data are presented which begin to lay the foundations for understanding the adsorption capabilities of ACFs essential to establishing a predictive model.
Intelligent agents for intrusion detection (2002)

The paper focuses on intrusion detection and countermeasures with respect to widely-used operating systems and networks. The design and architecture of an intrusion detection system built from distributed agents is proposed to implement an intelligent system on which data mining can be performed to provide global, temporal views of an entire networked system. A starting point for agent intelligence in the system is the research into the use of machine learning over system call traces from the privileged sendmail program on UNIX. The authors use a rule learning algorithm to classify the system call traces for intrusion detection purposes and show the results.
Subdiffractive all-photonic crystal Fabry-Perot resonators (2008)

We propose subdiffractive all-photonic crystal Fabry-Perot resonators and study light propagation in this novel system. The photonic crystal in the cavity is tuned to the subdiffractive regime and the mirrors to the center of the photonic bandgap. We show that such all-photonic crystal resonators exhibit a broadband angular transmission at a fixed frequency and a high Q factor, resulting in a drastic reduction of the power threshold for all-optical switching.
Intraarticular analgesia after arthroscopic knee surgery: comparison of neostigmine, clonidine, tenoxicam, morphine and bupivacaine (2005)

We conducted a randomized, placebo-controlled, double blinded study to compare the analgesic effects of intraarticular neostigmine, morphine, tenoxicam, clonidine and bupivacaine in 150 patients undergoing arthroscopic knee surgery. General anaesthesia protocol was same in all patients. At the end of the surgical procedure, patients were randomized into six intraarticular groups equally. Group N received 500 mug neostigmine, Group M received 2 mg morphine, Group T received 20 mg tenoxicam, Group C received 1 microg kg(-1) clonidine, Group B received 100 mg bupivacaine and Group S received saline 20 ml. Visual analog scale scores 0, 30 and 60 min and 2, 4, 6, 12, 24, 48 and 72 h, time to first analgesic need, analgesic consumption at 48 h and 72 h and side effects were noted. Demographic and operational parameters were similar in six groups. All study groups provided analgesia when compared with saline group (P<0.05). Duration of analgesia in Group N and C was longer than other groups (P<0.001). Analgesic consumptions of Group N, C and T were lower than other groups (P<0.01). Pain scores during 2 h postoperatively were lower in all study groups than the control group (P<0.001). In Group B, median pain scores were higher than Groups N and C at 0 min and 30 min postoperatively (P<0.001). Side effects were not significantly different among the six groups. We conclude that the most effective drugs that are administered intraarticularly are neostigmine and clonidine among the five drugs we studied. Tenoxicam provided longer analgesia when compared with morphine and bupivacaine, postoperatively.
Graft Fixation Alternatives in Anterior Cruciate Ligament Reconstruction (2002)

Reconstruction of the anterior cruciate ligament is a frequently performed procedure with outstanding results. Results are dependent upon an early postoperative physical therapy pro- gram that stresses early motion. Early rehabilitation demands rigid intraoperative mechanical fixation of the graft since therapy begins prior to biologic incorporation of the graft in the bone tunnels. Regardless of the graft substitute chosen, many methods of fixa- tion are available. The best fixation technique depends upon several factors including graft choice and surgeon comfort. We review current methods available for graft fixation in anterior cru- ciate ligament surgery.
Trust In and Adoption of Online Recommendation Agents (2005)

Online product recommendation agents are becoming increasingly prevalent on a wide range of websites. These agents assist customers in reducing information overload, providing advice to find suitable products, and facilitating online decision-making. Consumer trust in recommendation agents is an integral factor influencing their successful adoption. However, the nature of trust in technological artifacts is still an under-investigated and not well understood topic. Online recommendation agents work on behalf of individual users (principals) by reflecting their specific needs and preferences. Trust issues associated with online recommendation agents are complicated. Users may be concerned about the competence of an agent to satisfy their needs as well as its integrity and benevolence in regard to acting on their behalf rather than on behalf of a web merchant or a manufacture. This study extends the interpersonal trust construct to trust in online recommendation agents and examines the nomological validity of trust in agents by testing an integrated Trust-TAM (Technology Acceptance Model). The results from a laboratory experiment confirm the nomological validity of trust in online recommendation agents. Consumers treat online recommendation agents as " social actors" and perceive human characteristics (e.g., benevolence and integrity) in computerized agents. Furthermore, the results confirm the validity of Trust-TAM to explain online recommendation acceptance and reveal the relative importance of consumers' initial trust vis-¨¤-vis other antecedents addressed by TAM (i.e. perceived usefulness and perceived ease of use). Both the usefulness of the agents as "tools" and consumers' trust in the agents as "virtual assistants" are important in consumers' intentions to adopt online recommendation agents.