gebhart/patrepeval huggingface dataset:
Reservoir heterogeneities of storm-generated shelf sandstone bodies (1988)

Examination of a number of examples of storm-generated shelf sandstones, including part of the Kuparuk River formation (Cretaceous, North Slope of Alaska) and examples from the Cretaceous Western Interior seaway, suggests that these reservoirs differ in their geometries, internal facies architectures, and heterogeneities from continental, shoreline, and deep-water reservoirs. Heterogeneities inherent in such shelf sandstone reservoirs control the distribution of permeability and porosity and influence the effectiveness of recovery techniques. Sandstone bodies produced by storm-driven processes generally exhibit sheet-like geometries and upward-coarsening vertical profiles. These bodies are typically composed of individual event beds of every fine- to fine-grained sandstone and exhibit wave-generated and combined flow structures with laterally persistent mud drapes at their tops. The event nature of deposition of these sandstones produces a highly stratified reservoir. Vertical to horizontal permeability ratios are very low and individual sandstone beds may behave as separate conduits of flow during production. Hummocky cross-stratified beds at the tops of upward-coarsening sequences constitute the most permeable, porous, and laterally continuous parts of these reservoirs.
Flavour improvement of reduced-fat peanut butter by addition of a kokumi peptide, γ-glutamyl-valyl-glycine (2015)

Recent studies have demonstrated that kokumi substances, which enhance basic tastes and modify mouthfulness and continuity although they have no taste themselves, are perceived through the calcium-sensing receptor (CaSR). Screening by a CaSR assay and sensory evaluation have shown that γ-glutamyl-valyl-glycine (γ-Glu-Val-Gly) is a potent kokumi peptide. In our previous study, it was reported that the addition of γ-Glu-Val-Gly to chicken consommé significantly enhanced mouthfulness, continuity and thickness. In this study, the effect of γ-Glu-Val-Gly on reduced-fat peanut butter was investigated. Prior to the evaluation of the effect of γ-Glu-Val-Gly, a comparison test was conducted between full-fat model peanut butter and reduced-fat peanut butter. The sensory attributes in which the score of the full-fat model was significantly higher than that of the reduced-fat sample were used for the evaluation of the effect of γ-Glu-Val-Gly. The addition of γ-Glu-Val-Gly significantly enhanced thick flavour, aftertaste, and oiliness in the reduced-fat peanut butter. A kokumi peptide, γ-Glu-Val-Gly, can enhance thick flavour, aftertaste and oiliness in reduced-fat peanut butter. This suggests that addition of γ-Glu-Val-Gly can improve the flavour of low-fat foods.
Data from A Novel Anti-CD22 Anthracycline-Based Antibody–Drug Conjugate (ADC) That Overcomes Resistance to Auristatin-Based ADCs (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; We are interested in identifying mechanisms of resistance to the current generation of antibody–drug conjugates (ADC) and developing ADCs that can overcome this resistance.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Pinatuzumab vedotin (anti-CD22-vc-MMAE) and polatuzumab vedotin (anti-CD79b-vc-MMAE) are ADCs that contain the microtubule inhibitor monomethyl auristatin E (MMAE) attached to the antibody by the protease-cleavable linker maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl (MC-vc-PAB). Early clinical trial data suggest that these ADCs have promising efficacy for the treatment of non-Hodgkin lymphoma (NHL); however, some patients do not respond or become resistant to the ADCs. Anthracyclines are very effective in NHL, but ADCs containing the anthracycline doxorubicin were not clinically efficacious probably due to the low drug potency and inadequate linker technology. The anthracycline analogue PNU-159682 is thousands of times more cytotoxic than doxorubicin, so we used it to develop a new class of ADCs. We used the same MC-vc-PAB linker and antibody in pinatuzumab vedotin but replaced the MMAE with a derivative of PNU-159682 to make anti-CD22-NMS249 and tested it for &lt;i&gt;in vivo&lt;/i&gt; efficacy in xenograft tumors resistant to MMAE-based ADCs.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; We derived cell lines from &lt;i&gt;in vivo&lt;/i&gt; xenograft tumors that were made resistant to anti-CD22-vc-MMAE and anti-CD79b-vc-MMAE. We identified P-gp (ABCB1/MDR1) as the major driver of resistance to the vc-MMAE–based conjugates. Anti-CD22-NMS249 was at least as effective as anti-CD22-vc-MMAE in xenograft models of the parental cell lines and maintained its efficacy in the resistant cell lines.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; These studies provide proof of concept for an anthracycline-based ADC that could be used to treat B-cell malignancies that are resistant to vc-MMAE conjugates. &lt;i&gt;Clin Cancer Res; 21(14); 3298–306. ©2015 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Development of a Model for the .delta. Opioid Receptor Pharmacophore. 2. Conformationally Restricted Phe3 Replacements in the Cyclic .delta. Receptor Selective Tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]OH (JOM-13) (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDevelopment of a Model for the .delta. Opioid Receptor Pharmacophore. 2. Conformationally Restricted Phe3 Replacements in the Cyclic .delta. Receptor Selective Tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]OH (JOM-13)Henry I. Mosberg, John R. Omnaas, Andrei Lomize, Deborah L. Heyl, Ian Nordan, Carol Mousigian, Peg Davis, and Frank PorrecaCite this: J. Med. Chem. 1994, 37, 25, 4384–4391Publication Date (Print):December 1, 1994Publication History Published online1 May 2002Published inissue 1 December 1994https://pubs.acs.org/doi/10.1021/jm00051a016https://doi.org/10.1021/jm00051a016research-articleACS PublicationsRequest reuse permissionsArticle Views161Altmetric-Citations53LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
CMOS analog integrated circuits based on weak inversion operations (1977)

A simple model describing the DC behavior of MOS transistors operating in weak inversion is derived on the basis of previous publications. This model includes only two parameters and is suitable for circuit design. It is verified experimentally for both p- and n-channel test transistors of a Si-gate low-voltage CMOS technology. Various circuit configurations taking advantage of weak inversion operation are described and analyzed: two different current references based on known bipolar circuits, an amplitude detector scheme which is then applied to a quartz oscillator with the result of a very low-power consumption (<0.1 /spl mu/W at 32 kHz), and a low-frequency bandpass amplifier. All these circuits are insensitive to threshold and mobility variations, and compatible with a CMOS technology dedicated to digital low-power circuits.
ChemInform Abstract: Enantioselective Addition of Organometallics to Aldehydes Using Camphor Derived Chiral 1,4‐Aminoalcohols as Ligands. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Differentially Private k-Means with Constant Multiplicative Error (2018)

We design new differentially private algorithms for the Euclidean k-means problem, both in the centralized model and in the local model of differential privacy. In both models, our algorithms achieve significantly improved error guarantees than the previous state-of-the-art. In addition, in the local model, our algorithm significantly reduces the number of interaction rounds. Although the problem has been widely studied in the context of differential privacy, all of the existing constructions achieve only super constant approximation factors. We present, for the first time, efficient private algorithms for the problem with constant multiplicative error. Furthermore, we show how to modify our algorithms so they compute private corsets for k-means clustering in both models.
Pravastatin and the Development of Diabetes Mellitus (2001)

We concluded that the assignment to pravastatin therapy resulted in a 30% reduction (P:=0.042) in the hazard of becoming diabetic. By lowering plasma triglyceride levels, pravastatin therapy may favorably influence the development of diabetes, but other explanations, such as the anti-inflammatory properties of this drug in combination with its endothelial effects, cannot be excluded with these analyses.
A mannosyl-carrier lipid of bovine adrenal meddulla and rat parotid (1975)

1. The transfer of mannose from GDP-(U-14-C)mannose into endogenous acceptors of bovine adrenal medullla and rat parotid was studied. The rapidly labelled product, a glycolipid, was partially purified and characterized. 2. It was stable to mild alkaline hydrolysis but yielded (14-C)mannose on mild acid hydrolysis. It co-chromatographed with mannosyl phosphoryl dolichol in four t.l.c. systems and on DEAE-cellulose acetate. Addition of dolichol phosphate or a dolichol phosphate-enriched fraction prepared from pig liver stimulated mannolipid synthesis. 3. The formation of mammolipid appeared reversible, since addition of GDP to a system synthesizing the mannolipid caused a rapid loss of label from the mannolipid. UDP-N-acetylglucosamine did not inhibit mannolipid synthesis except at high concentrations (2 mM), even though in the absence of GDP-mannose, N-acetylglucosamine was incorporated into a lipid having the properties of a glycosylated polyprenyl phosphate. 4. Mannose from GDP-mannose was also incorporated into two other acceptors, (2y being insoluble in chloroform-methanol (2:1, v/v) but soluble in choloroform-methanol-water (10:10:3, by vol.) and (ii) protein. These are formed much more slowly than the mannolipid. 5. Exogenous mannolipid served as a mannose donor for acceptors (i) and (ii), and it is suggested that transfer of mannose from GDP-mannose to mannosylated protein occurs via two intermediates, the mannolipid and acceptor (i).
Evaluation of Legal Risks for E-Commerce in Construction (2006)

E-commerce is steadily becoming a reality in the construction industry. However, despite the increasing rate of utilization by owners and contractors alike, the legal implications of using e-commerce in construction have not been studied in depth. This paper fills this gap in literature. It identifies and analyzes the different types of legal risks involved in the use of e-commerce in construction. It also outlines the risk that contractors and professionals may face in their e-commerce implementations. A classification of e-commerce legal risks is also introduced. The legal risks discussed include agency, jurisdiction, contract formation, validity and errors, authentication, attribution, nonrepudiation, privacy, conflict of laws, and conflict between law and technology.
Dry air entrainment into convective clouds (1977)

A systematic approach to the study of atmospheric turbulent motion is discussed in terms of weather modification. The background of cloud physics, and the mixing process are described. A zero-g study is proposed to enable the basic experimental data to be collected so that theory may be developed to generalize results for practical applications.
Associations between Bladder Cancer Risk Factors and Tumor Stage and Grade at Diagnosis (1994)

Using data on 1,860 bladder cancer cases and 3,934 population-based controls from the National Bladder Cancer Study, we examined associations between suspected bladder cancer risk factors and tumor stage and grade. Employment in a high-risk occupation was associated with the entire clinical spectrum of bladder cancer rather than a particular tumor stage or grade. For example, relative risks (RR) were similar for noninvasive and invasive disease (1.5 and 1.6, respectively). Cigarette smoking also increased risk of the entire clinical spectrum of bladder cancer, but the more advanced the stage, the stronger the effect. For example, relative risks of noninvasive and invasive bladder cancer for current heavy smokers were 3.0 and 5.2, respectively. Cigarette smoking was associated with higher risk of low-grade than high-grade tumors, once stage of disease was taken into account. Compared with whites, nonwhites were at a lower risk of noninvasive bladder cancer (RR = 0.4) but at similar risk of invasive bladder cancer (RR = 1.1), a pattern indicating racial differences in health practices related to bladder cancer detection. History of urinary tract infections and bladder stones was associated with increasing relative risks for advanced tumor stage. Heavy artificial sweetener use was associated with higher-grade, poorly differentiated tumors. Coffee consumption and family history of bladder cancer were not consistently associated with tumor stage or grade. Overall, different clinical presentations of bladder cancer share most suspected bladder cancer risk factors, including employment in a high-risk occupation and cigarette smoking.
Established PABPN1 intranuclear inclusions in OPMD muscle can be efficiently reversed by AAV-mediated knockdown and replacement of mutant expanded PABPN1 (2019)

Oculopharyngeal muscular dystrophy (OPMD) is a rare autosomal dominant late-onset muscular dystrophy affecting approximately 1:100 000 individuals in Europe. OPMD is mainly characterized by progressive eyelid drooping (ptosis) and dysphagia although muscles of the limbs can also be affected late in life. This muscle disease is due to a trinucleotide repeat expansion in the polyA-binding protein nuclear-1 gene. Patients express a protein with an 11-18 alanine tract that is misfolded and prone to form intranuclear inclusions, which are the hallmark of the disease. Other features of OPMD include muscle fibrosis and atrophy in affected muscles. Currently, no pharmacological treatments are available, and OPMD patients can only be referred to surgeons for cricopharyngeal myotomy or corrective surgery of extraocular muscles to ease ptosis. We recently tested a two-AAV `silence' and `replace' vector-based gene therapy treatment in a mouse model of OPMD. We demonstrate here that this gene therapy approach can revert already established insoluble aggregates and partially rescues the muscle from atrophy, which are both crucially important since in most cases OPMD patients already have an established disease when diagnosed. This strategy also prevents the formation of muscle fibrosis and stabilizes the muscle strength to the level of healthy muscles. Furthermore, we show here that similar results can be obtained using a single AAV vector incorporating both the `silence' and `replace' cassettes. These results further support the application of a gene therapy approach as a novel treatment for OPMD in humans.
Biosourced polymer foam production using a (SC CO2) -assisted extrusion process (2010)

International audience
Understanding bitumen recovery from oil sands through Colloidal and interfacial phenomena (2004)

"Summary form only given". Canadian oil sands are unconsolidated sand deposits that are impregnated with heavy, viscous petroleum, normally referred to as bitumen. The total bitumen in place in Alberta is estimated at 1.7 to 2.5 trillion barrels and is clearly massive by world standards. Presently, 25% of the Canadian energy needs are derived from upgraded bitumen from mined oil sands. The oil sands are a complex mixture containing bitumen, mineral solids, clays, connate water and salts. The bitumen recovery from the oil sands using water extraction processes involves bitumen separation from the sand grains and air-bitumen attachment for subsequent flotation. Colloidal, interfacial and electrokinetic phenomena play a major role in bitumen recovery from oil sands using water based extraction processes. Through the use of basic scientific tools at the micro and molecular scales, we were able to understand the working of what is considered to be a mega scale industrial process. Electrophoretic and atomic force balance measurements were used to establish the reasons for the observed low bitumen recovery in the presence of fine solids and divalent ions. As well, impinging jet deposition experiments were utilized to ascertain the ability of air-bitumen attachment under different physicochemical environment. The behavior of the bitumen-water interface was studied to better understand the formation of stable water-in-bitumen emulsions. Langmuir trough and micro-pipette techniques were employed to elucidate the fundamental role of deemulsifiers. The presentation will illustrate how one can within a University environment study a complex industrial process that is of great importance to the Canadian Energy Sector.
Abstract 2044: Chemotherapy induced neutropenia in rats following administration of eflapegrastim or pegfilgrastim on the same day at three different timepoints and at 24 hours post-chemotherapy (2020)

Abstract Background: Eflapegrastim is a long-acting G-CSF that is comprised of a G-CSF analog and a recombinant IgG4 Fc fragment conjugated at their N-termini via a short polyethylene glycol linker. Currently, G-CSF products are administered 24 hours after chemotherapy. We compared the duration of neutropenia (DN) after treatment with eflapegrastim and pegfilgrastim given on the same-day, at three different timepoints, and after 24 hours in chemotherapy-induced neutropenic rats. Method: Neutropenia was induced in rats via intraperitoneal administration of cyclophosphamide and docetaxel (TC) chemotherapy. Rats (5 animals per group) were assigned to dose groups of either vehicle or equivalent doses (based on human clinical doses) of pegfilgrastim (103.3 µg/kg) or eflapegrastim (61.8 µg/kg as G-CSF) on the same day as chemotherapy at 0, 2, and 5 hours or 24 hours after chemotherapy. The primary endpoint was the difference in DN after TC treatment and administration of eflapegrastim or pegfilgrastim at the specified timepoints. Results: In the vehicle group, the TC regimen induced neutropenia in all animals with an ANC nadir occurring on approximately Day 4 and a mean DN of nearly 7 days. The mean DN values for treatment with eflapegrastim on the same day, at 0, 2, and 5 hours, and after 24 hours were similar and the mean DN values for eflapegrastim were significantly lower than for pegfilgrastim at all dosing timepoints (Table). Time after Chemotherapy(hours)Mean Duration of Neutropenia (days)Difference (95% CI)Eflapegrastim Time vs 24 hoursDifference (95% CI)EflapegrastimPegfilgrastim00.62.2-1.6 (-3.067, -0.133)0.4 (-0.08, 1.28)20.21.8-1.6 (-2.84, -0.36)0 (-0.19, 0.59)50.01.2-1.2 (-1.20, -1.20)-0.2 (0, 0)240.21.8-1.6 (-2.84, -0.36)NA Conclusions: The DN for same-day treatment with eflapegrastim at 0, 2, and 5 hours was similar to that of the treatment after 24-hours. However, the mean DN values were significantly lower for eflapegrastim than pegfilgrastim at all time points. Further exploration of the potential advantage of same-day dosing with eflapegrastim in patients undergoing chemotherapy is warranted. Citation Format: Yu-Yon Kim, Eunjung Kim, Hyesun Han, Seungjae Baek, Shanta Chawla, Prasad Kolli, Gajanan Bhat, Francois Lebel. Chemotherapy induced neutropenia in rats following administration of eflapegrastim or pegfilgrastim on the same day at three different timepoints and at 24 hours post-chemotherapy [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 2044.
Effect of a very late antigen‐4 receptor antagonist on allergen‐induced airway responses and inflammation in asthma (2005)

Treatment with multiple inhaled doses of the VLA(4) antagonist, HMR 1031, did not result in detectable protection against allergen-induced airway responses or airway inflammation in asthma.
Spatial modulation: optimal detection and performance analysis (2008)

In this letter, we derive the optimal detector for the so-called spatial modulation (SM) system introduced by Mesleh et al. in (Mesleh, 2006). The new detector performs significantly better than the original (~ 4 dB gain), and we support our results by deriving a closed form expression for the average bit error probability. As well, we show that SM with the optimal detector achieves performance gains (~ 1.5 - 3 dB) over popular multiple antenna systems, making it an excellent candidate for future wireless communication standards.
Reduced digging and marble burying behaviour of <i>Fpr2/3</i><sup>-/-</sup> mice in the marble burying test. (2015)

&lt;p&gt;The bar graphs and relative pictures show the total number of buried marbles, total duration (seconds) of digging and the latency (seconds) to the first digging bout during a 10-minute trial. Values are expressed as median ± S.E.M. and representative of four different experiments involving 6–9 mice per group. * &lt;i&gt;P&lt;/i&gt;&lt;0.05 and ** &lt;i&gt;P&lt;/i&gt;&lt;0.05 indicate significant values compared with wild-type (WT) control mice (Mann–Whitney &lt;i&gt;U&lt;/i&gt;-test).&lt;/p&gt;
Boundary conditions for the diffusion equation in radiative transfer (1994)

Using the method of images, we examine the three boundary conditions commonly applied to the surface of a semi-infinite turbid medium. We find that the image-charge configurations of the partial-current and extrapolated-boundary conditions have the same dipole and quadrupole moments and that the two corresponding solutions to the diffusion equation are approximately equal. In the application of diffusion theory to frequency-domain photon-migration (FDPM) data, these two approaches yield values for the scattering and absorption coefficients that are equal to within 3%. Moreover, the two boundary conditions can be combined to yield a remarkably simple, accurate, and computationally fast method for extracting values for optical parameters from FDPM data. FDPM data were taken both at the surface and deep inside tissue phantoms, and the difference in data between the two geometries is striking. If one analyzes the surface data without accounting for the boundary, values deduced for the optical coefficients are in error by 50% or more. As expected, when aluminum foil was placed on the surface of a tissue phantom, phase and modulation data were closer to the results for an infinite-medium geometry. Raising the reflectivity of a tissue surface can, in principle, eliminate the effect of the boundary. However, we find that phase and modulation data are highly sensitive to the reflectivity in the range of 80-100%, and a minimum value of 98% is needed to mimic an infinite-medium geometry reliably. We conclude that noninvasive measurements of optically thick tissue require a rigorous treatment of the tissue boundary, and we suggest a unified partial-current--extrapolated boundary approach.