gebhart/patrepeval huggingface dataset:
Maximal matching characterization of optical packet input-buffered wavelength routed switches (2004)

The shared wavelength path (SHWP) and the scattered wavelength path (SCWP) were proposed under the WASPNET (wavelength switched packet network) project. They are the envisaged operating mode competing alternatives for optical packet switching in the WDM networking context. A maximum matching model is presented to evaluate the performance of the input-buffered wavelength-routed (IB-WR) optical packet switch, under both SHWP and SCWP switching modes. We conduct a necessary set of modifications for this architecture, which was not originally conceived with a SCWP/SHWP scheme in mind. The characterization proposed is based on the establishment of independent maximum size matching or maximum weight matching optimization problems. It provides a method to calculate the optimum performance achievable by this architecture in terms of switch throughput and average delay, for both the SHWP and SCWP operational modes. The modeling may consider additional conditions to maintain, or not, the packet sequence. Besides that, our approximation establishes a framework for the study of simple scheduling processes which take benefit of the simple hardware requirements associated with IB-WR architecture. As an example, a sequential SHWP scheduler presented by IB-WR switch designers, and its SCWP evolution, which we present, are evaluated and compared.
Antimicrobial effect of zinc pyrithione (1982)

The antimicrobial effect of zinc pyrithione has been studied with healthy scalps in relation to its ANTIDANDRUFF effect. Use of zinc pyrithione-containing shampoo sharply reduced the CORNEOCYTE COUNTS, while the similarly active antimicrobial gent, Irgasan DP-300 © had no effect on the corneocyte counts. Quantitative stimation of scalp microorganisms revealed that corresponding to the decrease indandruff, Pityrospbrum ovale were specifically lowered by zinc pyrithione treatments, but not by Irgasan DP-300 ©. Subsequent observations without shampooing indicated that the corneocyte count recovered to control evel after 6 days despite the continued suppression f Pityrosporum ovale. In contrast, non-medicated shampooing, after the suppression of dandruff by zinc pyrithione, showed a continued reduced corneocyte count despite recovered growth of Pityrosporum ovale.
Cell cycle-independent induction of apoptosis by the anti-tumor drug flavopiridol in endothelial cells (1998)

The anti-tumor drug Flavopiridol is a potent inhibitor of cyclin-dependent kinases (cdks). As a consequence, Flavopiridol-treated cells arrest in both G1 and G2, but Flavopiridol has also been shown to be cytotoxic for some tumor cell lines. The underlying molecular events are, however, unclear. We now show that Flavopiridol induces apoptosis in human umbilical vein endothelial cells (HUVECs), as judged by the occurrence of classical apoptotic markers, including chromatin condensation, internucleosomal cleavage, DNA fragmentation (TUNEL assay), annexin V binding and poly(ADP-ribose) polymerase (PARP)-cleavage. Such induction of apoptosis occurs with equal efficiency in both proliferating and G0/G1-arrested cells. Because growth-arrested HUVECs lack cdk2 activity and contain high levels of the cdk inhibitor p27, our observations suggest that cell cycle regulated cdks may not be the only critical target for Flavopiridol-induced apoptosis. Surprisingly, A549 lung carcinoma cells were clearly dependent on cell proliferation for the induction of cell death, pointing to cell type-related differences in the mechanism of Flavopiridol action.
Peptide immunotherapy for allergic diseases (2007)

Specific allergen immunotherapy has been widely practised for almost 100 years. Whilst this approach is disease-modifying and efficacious, the use of whole allergen preparations is associated with an unacceptably high prevalence of allergic adverse events during treatment. Many approaches to reduce the allergenicity of immunotherapy preparations whilst maintaining immunogenicity are under development. One such approach is the use of short synthetic peptides which represent major T-cell epitopes of the allergen. Major potential advantages of this approach include markedly reduced capacity to cross-link immunoglobulin-E and activate mast cells and basophils, and ease of manufacture and standardization. Promising results in preclinical studies have led to the translation of this approach to clinical studies in humans. Peptide immunotherapy is currently under development for allergic and autoimmune diseases.
Nitroxide‐Mediated Aqueous Dispersion Polymerization: From Water‐Soluble Macroalkoxyamine to Thermosensitive Nanogels (2007)

Abstract Self‐stabilized nanoparticles with a temperature‐responsive poly[( N , N ‐diethylacrylamide)‐ co ‐( N , N ′‐methylenebisacrylamide)] microgel core and a covalently attached hairy shell were synthesized via a simple nitroxide‐mediated controlled free‐radical aqueous dispersion polymerization, using a poly(sodium acrylate) alkoxyamine macroinitiator. With this method, high solid content, surfactant‐free particle suspensions were prepared, with diameter ranging from 49 to 118 nm at high temperature, and able to reversibly swell with water at low temperature. The proposed method requires a limited number of reagents in a simple polymerization procedure and thus avoids many drawbacks generally encountered in the synthesis of thermally responsive microgel particles. magnified image
Graphene K‐Tape Meshes for Densely Distributed Human Motion Monitoring (2020)

Abstract Wearable sensors that measure parameters associated with physical activity and bodily motions have been regarded as an indispensable tool for assessing personal wellness. Recent advances in nanocomposite strain sensors have been successfully used for monitoring skin strains and other strain‐derived physiological parameters. This study complements the existing body of work and presents a flexible, self‐adhering, fabric‐based wearable sensor for measuring skin strains and human motions. Graphene nanosheet thin films are directly spray‐coated onto kinesiology tape (K‐Tape) to obtain a self‐adhering strain sensor of high sensitivity and linearity. Their stable sensing performance and high repeatability are verified, while human subject tests confirm that they adequately capture muscle engagement during functional movements. In addition, densely distributed strain monitoring can be achieved using an electrical impedance tomography measurement approach and algorithm. Spatial strain sensing is successfully demonstrated using a single strip of piezoresistive K‐Tape, as well as when a K‐Tape network or mesh pattern is formed. The results show promise for using graphene K‐Tape meshes to measure how specific major muscle groups engage during different physical activities.
MRI Imaging in an NF2 Patient with a Novel MRI Compatible Auditory Brain Stem Implant (2017)

Auditory brain stem implantation has become a key technique for the rehabilitation of hearing in patients with neurofibromatosis 2. The nature of this devastating genetic disease requires ongoing MRI imaging for the lifespan of the patient. Today, the majority of auditory brainstem implants require removal of the magnet that connects the internal device to the external speech processor to undergo imaging as their disease progresses. Patients have the option of having a short procedure to have the magnet taken out and replaced each time, or alternately using a headband to secure the processor over the receiver coil of the internal device. Novel magnet technology has led to the development of a freely rotating magnet that can be used inside the magnetic field of an MRI scanner without losing magnet strength and without being displaced from the body of the device. We report one of the first patient implanted with a MedEl synchrony ABI in the United States whose subsequently underwent successful imaging with MRI 1.5 Tesla to follow for other existing schwannomas.
Několik poznámek k postavení učitele v naší společnosti (2018)

N/A
Urazole as an unorthodox functional group for fabrication of anionic hydrogels and ion-exchange materials (2021)

In this study, highly ionazable protons (pKa 5-6) of urazole were exploited to obtain an anionic hydrogel in two simple and scalable steps. Commercially available multiisocyanate, poly(hexamethylene)diisocyanate, was used to prepare urazole containing gel. Urazole formation was confirmed by FT-IR and 1H-NMR spectroscopy. The hydrogel were characterized by microscopy imaging, spectroscopic and gravimetric analysis. Mechanical analysis and cell viability test were performed for its initial biocompatibility evaluation. The prepared hydrogel is a highly porous hydrogel with a Young’s modulus of 0.91MPa, has swelling ratio of 87% and capable of exchanging ions in a medium. In this report, we demonstrated a strategy to overcome synthetic challenge of incorporating urazole into a material via precursor path rather than attempting to embeding urazole groups directly.
Coordinated nocturnal behavior of foraging jumbo squid Dosidicus gigas (2012)

We used split-beam acoustic techniques to observe free-swimming of jumbo squid Dosidicus gigas during 4 cruises in the Gulf of California. Four-dimensional spatio-temporal data revealed that at night in shallow water, jumbo squid were using ascending, spiral-like swimming paths to emerge from extremely dense aggregations, and were likely foraging on potential prey that were found overlapping in depth with their tracks. Within small regions at the vertices of these swimming paths, individual squid swam back and forth repetitively before continuing their ascent. The behaviors observed in these high-use regions, described using density kernel statistics, are consistent with other observations of prey capture behavior by squid. Often, the observed swimming paths of individual squid were found to parallel those of other squid in depth over time. In addition to being coordinated in depth, movements of individuals within a group of up to 40 individuals were coordinated in horizontal space so that high-use areas were overlapping in horizontal space but separated vertically. The resulting groups of tracks look like interwoven multiple helices anchored at their vertices by bouts of presumed feeding. These highly polarized, complex, coordinated movement patterns constitute schooling. Polarization in these groups did not break down during apparent feeding events as has been observed in other species. In fact, the feeding events themselves may define the anchor for group behavior. Schooling of jumbo squid school will likely be critical in understanding many aspects of their biology.
Image Aesthetics Assessment Using Composite Features from off-the-Shelf Deep Models (2018)

Deep convolutional neural networks have recently achieved great success on image aesthetics assessment task. In this paper, we propose an efficient method which takes the global, local and scene-aware information of images into consideration and exploits the composite features extracted from corresponding pretrained deep learning models to classify the derived features with support vector machine. Contrary to popular methods that require fine-tuning or training a new model from scratch, our training-free method directly takes the deep features generated by off-the-shelf models for image classification and scene recognition. Also, we analyzed the factors that could influence the performance from two aspects: the architecture of the deep neural network and the contribution of local and scene-aware information. It turns out that deep residual network could produce more aesthetics-aware image representation and composite features lead to the improvement of overall performance. Experiments on common large-scale aesthetics assessment benchmarks demonstrate that our method outperforms the state-of-the-art results in photo aesthetics assessment.
Calibration-free match finding between vision and LIDAR (2015)

We present a learning approach that allows to detect correspondences between visual and LIDAR measurements. In contrast to approaches that rely on calibration, we propose a learning approach that will create an implicit calibration model from training data. Our model can provide three functions: first of all, it can convert a measurement in one sensor into the coordinate system of the other, or into a distribution of probable measurements in case the transformation is not unique. Secondly, using a correspondence observation that we define, the model is able to decide if two visual/LIDAR measurements are likely to come from the same object. This is of profound importance for applications such as object detection or tracking where contributions from several sensors need to be combined. We demonstrate the feasibility of our approach by training and evaluating our system on tracklets in the KITTI database as well as on a small set of real-world scenes containing pedestrians, in which our method finds correspondences between the results of real visual and LIDAR-based detection algorithms.
Online IMU Self-Calibration for Visual-Inertial Systems (2019)

Low-cost microelectro mechanical systems (MEMS)-based inertial measurement unit (IMU) measurements are usually affected by inaccurate scale factors, axis misalignments, and g-sensitivity errors. These errors may significantly influence the performance of visual-inertial methods. In this paper, we propose an online IMU self-calibration method for visual-inertial systems equipped with a low-cost inertial sensor. The goal of our method is to concurrently perform 3D pose estimation and online IMU calibration based on optimization methods in unknown environments without any external equipment. To achieve this goal, we firstly develop a novel preintegration method that can handle the IMU intrinsic parameters error propagation. Then, we frame IMU calibration problem into general factors so that we can easily integrate the factors into the current graph-based visual-inertial frameworks and jointly optimize the IMU intrinsic parameters as well as the system states in a big bundle. We evaluate the proposed method with a publicly available dataset. Experimental results verify that the proposed approach is able to accurately calibrate all the considered parameters in real time, leading to significant improvement of estimation precision of visual-inertial system (VINS) compared with the estimation results with offline precalibrated IMU measurements.
Pharmacological Modulation of B16‐F10 Murine Melanoma‐Induced TAMs Functional Phenotype via Lipoprotein‐Based Nanoparticles (2022)

Tumor‐associated macrophages (TAMs) are one of the most abundant immune cells in the tumor microenvironment (TME). Their immunosuppressive phenotype (M2) promotes tumor progression. The re‐education of TAMs in the TME to a pro‐immune phenotype (M1) is considered to enhance the effectiveness of the anti‐tumor immune response and leads to tumor regression. An effective therapeutic approach utilizing macrophage re‐polarization will likely require the selective delivery of agents to the TME to execute the M2‐to‐M1 phenotype transformation. This strategy is known to avoid adverse immune‐related events through the utilization of nanocarriers that can effectively penetrate the TME and interact with TAMs. As a drug delivery platform, reconstituted high‐density lipoprotein nanoparticles (rHDL NPs) have attracted increased interest in cancer therapeutics, owing to their biocompatibility and their capacity to transport lipophilic drugs toward their accumulation in the tumor. We and others have shown that the scavenger receptor class B type 1 (SR‐B1), at the surface of target cells, mediates the intracellular (non‐endocytic) delivery of rHDL NPs’ payload. The novel lipophilic agonist of the STimulator of INterferon Genes (STING), MSA‐2, has been used successfully to mediate the M2‐to‐M1 reversal in murine models of cancer. In this study, we aim to deliver MSA‐2 to TAMs using mannose‐decorated rHDL NPs to induce a conversion to an M1 phenotype. Because TAMs highly express the mannose receptor CD206 that facilitates the interaction of mannose with TAMs, inducing an M1 phenotype, we anticipate a successful outcome based on this strategy. We prepared and validated the retention of the PEGylated mannose moiety on the rHDL NPs. Fluorescence anisotropy and absorbance studies showed that rHDL NPs successfully encapsulated MSA‐2. IL‐4‐induced M2 macrophages and B16‐F10 murine melanoma conditioned media‐induced TAMs showed a higher SR‐B1 expression compared to M1 macrophages. The lower uptake of the surrogate dye payload by M1 macrophages (compared to M2 macrophages and TAMs) from the mannose‐decorated rHDL NPs, corroborates the importance of the SR‐B1 receptor in rHDL payload delivery. The above findings have significant therapeutic implications for the strategy of utilizing mannose‐decorated rHDL‐NPs to selectively target TAMs in the tumor microenvironment. In addition, this formulation of MSA‐2 with the mannose‐decorated rHDL NPs can be applied in a synergistic combination with mainstream immunotherapies to improve treatment outcomes for cancer patients, diagnosed with solid tumors.
Handbook of Biomedical Optics, by David A Boas, Constantinos Pitris, and Nimmi Ramanujam (2011)

The <i>Journal of Biomedical Optics</i> (JBO) is a Gold Open Access journal that publishes peer-reviewed papers on the use of novel optical systems and techniques for improved health care and biomedical research.
Effect of an Ultrahigh b Value of 3000 s/mm<sup>2</sup> and the Minimal Echo-time on Image Quality and the T2 Shine-through Effect in Diffusion-weighted Imaging of the Liver at 3T: Phantom and Clinical Pilot Studies (2022)

Liver DWI at the ultrahigh b value can reduce the T2 shine-through effect with improvement of image quality using the minimal TE.
Phytoremediation of lowland soil contaminated with a formulated mixture of Imazethapyr and Imazapic1 (2015)

The use of plants to decontaminate water and soil contaminated with both organic and inorganic pollutants is a promising technology for sustainable agriculture. The aim of this work was to evaluate the efficiency of plant species in the remediation of formulated mixtures of imazethapyr and imazapic, using the irrigated rice cultivar IRGA 417 as bioindicator. The treatments consisted of the combination of 13 plant species with seven rates of a formulated mixture of imazethapyr and Imazapic (75+25 g e.a. L-1 respectively): 0, 200, 300, 400, 500, 1000 and 4000 mL ha-1. To evaluate the potential for phytoremediation in these species, symptoms of injury and plant height were measured in rice plants at 7, 14, 21 and 28 days after emergence and shoot dry weight at 28 days after emergence. Glycine max, Lolium multiflorum and Lotus corniculatus are potentially promising species in the phytoremediation of soils contaminated with the herbicide imazethapyr and imazapic (up to 4000 mL ha-1), due to being more adapted to hydromorphic environments, which is a feature found in soils cultivated with irrigated rice. Crotalaria juncea, Canavalia ensiformis, Stizolobium aterrimum, Vicia sativa, Raphanus sativus and Triticum aestivum are species capable of the phytoremediation of soils contaminated with imazethapyr + imazapic, however the occurrence of anoxia in hydromorphic soils reduce the establishment and development of these plants.
The Importance of Oral Health in Comprehensive Health Care (2018)

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Intracellular and Extracellular Expression of Bacillus thuringiensis Crystal Protein Cry5B in Lactococcus lactis for Use as an Anthelminthic (2015)

The Bacillus thuringiensis crystal (Cry) protein Cry5B (140 kDa) and a truncated version of the protein, tCry5B (79 kDa), are lethal to nematodes. Genes encoding the two proteins were separately cloned into a high-copy-number vector with a strong constitutive promoter (pTRK593) in Lactococcus lactis for potential oral delivery against parasitic nematode infections. Western blots using a Cry5B-specific antibody revealed that constitutively expressed Cry5B and tCry5B were present in both cells and supernatants. To increase production, cry5B was cloned into the high-copy-number plasmid pMSP3535H3, carrying a nisin-inducible promoter. Immunoblotting revealed that 3 h after nisin induction, intracellular Cry5B was strongly induced at 200 ng/ml nisin, without adversely affecting cell viability or cell membrane integrity. Both Cry5B genes were also cloned into plasmid pTRK1061, carrying a promoter and encoding a transcriptional activator that invoke low-level expression of prophage holin and lysin genes in Lactococcus lysogens, resulting in a leaky phenotype. Cry5B and tCry5B were actively expressed in the lysogenic strain L. lactis KP1 and released into cell supernatants without affecting culture growth. Lactate dehydrogenase (LDH) assays indicated that Cry5B, but not LDH, leaked from the bacteria. Lastly, using intracellular lysates from L. lactis cultures expressing both Cry5B and tCry5B, in vivo challenges of Caenorhabditis elegans worms demonstrated that the Cry proteins were biologically active. Taken together, these results indicate that active Cry5B proteins can be expressed intracellularly in and released extracellularly from L. lactis, showing potential for future use as an anthelminthic that could be delivered orally in a food-grade microbe.
Techniques for reading DVD-RAM disc with DVD-ROM drives (1999)

We have developed techniques to read DVD-RAM discs with DVD-ROM drives. The key techniques are the reduction of feedthrough in the focusing error signal, the reduction of the push-pull signal offset, and the half tracking jump function.