gebhart/patrepeval huggingface dataset:
Properties of Rat Brain Microsomal Ribonucleic Acid Containing Polyadenylate (1975)

Conference Article| February 01 1975 Properties of Rat Brain Microsomal Ribonucleic Acid Containing Polyadenylate JOHN O. WHITE; JOHN O. WHITE 1Miriam Marks Department of Neurochemistry, Institute of Neurology, Queen Square, London WC1N 3BG, U.K. Search for other works by this author on: This Site PubMed Google Scholar CHRISTINE HALL; CHRISTINE HALL 1Miriam Marks Department of Neurochemistry, Institute of Neurology, Queen Square, London WC1N 3BG, U.K. Search for other works by this author on: This Site PubMed Google Scholar LOUIS LIM; LOUIS LIM 1Miriam Marks Department of Neurochemistry, Institute of Neurology, Queen Square, London WC1N 3BG, U.K. Search for other works by this author on: This Site PubMed Google Scholar ALAN N. DAVISON ALAN N. DAVISON 1Miriam Marks Department of Neurochemistry, Institute of Neurology, Queen Square, London WC1N 3BG, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1975) 3 (1): 94–95. https://doi.org/10.1042/bst0030094 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation JOHN O. WHITE, CHRISTINE HALL, LOUIS LIM, ALAN N. DAVISON; Properties of Rat Brain Microsomal Ribonucleic Acid Containing Polyadenylate. Biochem Soc Trans 1 February 1975; 3 (1): 94–95. doi: https://doi.org/10.1042/bst0030094 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1975 Biochemical Society1975 Article PDF first page preview Close Modal You do not currently have access to this content.
Telco clouds and Virtual Telco: Consolidation, convergence, and beyond (2011)

In this position paper we introduce Virtual Telco, a comprehensive effort to simplify the management of deployed telecommunication services by using a Cloud computing approach. The main objective of Virtual Telco is to replace the costly dedicated hardware implementing several centralized control plane functions and other services with distributed solutions that may be allocated on-demand over a pool of dependable, dynamically contracted computing and networking resources that are easy to manage. Virtual Telco relies on state-of-the-art techniques in the domains of virtualization and distributed systems to meet the challenging criteria of reliability, scalability, and timeliness required by present and future telecommunication standards and services. As a representative example of a Virtual Telco application, we propose the case of the distributed mobility management entity (MME) for next-generation LTE cellular networks.
Supplementary Figures 1 - 5 from Notch3 Pathway Alterations in Ovarian Cancer (2023)

&lt;p&gt;PDF file - 765K, Overall Survival (OS) Analysis in Patients With High-Grade Serous Ovarian Cancer HGS-OvCa (S1); In Vitro Functional Studies of Notch3 siRNA or GSI and combined with Paclitaxel in OvCa Cells (S2); qRT-PCR Analysis of Expression of Gamma-Secretase Complex in Ovarian Cancer Cells (S3); In vitro effects of blocking endocytosis on Jagged-1/Notch3 pathway in cancer cells (S4); In vivo study of Notch3 siRNA in orthotopic mouse models of ovarian cancer (S5).&lt;/p&gt;
Improved Arterial Compliance by a Novel Advanced Glycation End-Product Crosslink Breaker (2001)

ALT-711 improves total arterial compliance in aged humans with vascular stiffening, and it may provide a novel therapeutic approach for this abnormality, which occurs with aging, diabetes, and isolated systolic hypertension.
Comparative analysis of shape memory‐based self‐healing coatings (2016)

ABSTRACT Self‐healing materials exhibit the ability to repair and to recover their functionality upon damage. Here, we report on an investigation into preparation and characterization of shape memory assisted self‐healing coatings. We built on past work in which poly( ε ‐caprolactone) electrospun fibers were infiltrated with a shape memory epoxy matrix and delve into fabricating and characterizing a coating with the same materials, but employing a blending approach, polymerization induced phase separation. After applying controlled damage, the ability of both coatings to self‐heal upon heating was investigated. In both methods, coatings showed excellent thermally induced crack closure and protection against corrosion, with the blend approach being more suitable for large‐scale applications given its process simplicity. Two different approaches to the preparation of shape memory‐based self‐healing coatings were compared for their ability to heal structurally and functionally by heating. These two approaches, electrospinning versus polymerization‐induced phase separation were found to feature comparable and quite complete healing, with the latter system offering the advantage of facile processing. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2016 , 54 , 1415–1426
ChemInform Abstract: Dibenzo(d,h)(1,3,6,7,2)dioxadithiasilonin: Synthesis and Characterization. (1988)

Abstract 2,4‐Bis(tert‐butyl)phenol (I) is converted to the disulfide (V) via reductive cleavage of the trisulfide (III) followed by oxidative dimerization of the thiol (IV).
Signal transduction through gp130 that is shared among the receptors for the interleukin 6 related cytokine subfamily (1994)

Interleukin 6 (IL-6) and related cytokines, such as leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF) and IL-11 exhibit multiple functions and redundancy in biological activities and play important roles in the immune response, hematopoiesis, the nervous system and acute phase reactions. These IL-6 family cytokines exhibit a similar helical structure, and their receptors are structurally similar and constitute a cytokine receptor super family. In addition, a receptor subunit is shared among these IL-6 related cytokine subfamily receptors, contributing to one of the mechanisms of functional redundancy of cytokine activities and suggesting the presence of a common signal transduction pathway among these receptors. In this review, we describe the structure of the receptors for IL-6 and its related cytokine subfamily members. Furthermore, we propose a novel mechanism for the generation of cytokine diversity, i.e. the complex of a cytokine and one of its receptor subunits act as a novel cytokine on the cells that express the other receptor subunit(s) capable of acting as a receptor for the complex. Finally, we describe a Ras-independent novel signal transduction pathway that utilizes Jak tyrosine kinase family, Stat protein family and yet unidentified H-7-sensitive pathway. This signal transduction pathway is commonly generated through the receptors for a wide range of cytokines and growth factors.
Gynecological Cancers Translational, Research Implementation, and Harmonization: Gynecologic Cancer InterGroup Consensus and Still Open Questions (2019)

In the era of personalized medicine, the introduction of translational studies in clinical trials has substantially increased their costs, but provides the possibility of improving the productivity of trials with a better selection of recruited patients. With the overall goal of creating a roadmap to improve translational design for future gynecological cancer trials and of defining translational goals, a main discussion was held during a brainstorming day of the Gynecologic Cancer InterGroup (GCIG) Translational Research Committee and overall conclusions are here reported. A particular emphasis was dedicated to the new frontier of the immunoprofiling of gynecological cancers. The discussion pointed out that to maximize patients' benefit, translational studies should be integral to clinical trial design with standardization and optimization of procedures including a harmonization program of Standard Operating Procedures. Pathology-reviewed sample collection should be mandatory and ensured by dedicated funding. Biomarker validation and development should be made public and transparent to ensure rapid progresses with positive outcomes for patients. Guidelines/templates for patients' informed consent are needed. Importantly for the public, recognized goals are to increase the involvement of advocates and to improve the reporting of translational data in a forum accessible to patients.
Gold Springs Mining District, Iron County, Utah, and Lincoln County, Nevada (1976)

Gold and silver mineralization in the Gold Springs mining district on the Utah-Nevada border is restricted to veins in Tertiary volcanic rocks. Mining began in 1897 and continued intermittently until the early 1940's. The principal mines have been the Jennie, Little Buck, Snowflake, Independence, Aetna, and Jumbo. Three mines had mills where ores were beneficiated. However, these mills were primitive and met with varying success. Few records were kept; nevertheless the district is credited with producing 9,335 ounces of gold, 40,279 ounces of silver, 12,031 pounds of copper, and 19,268 pounds of lead. The past production and this study of the surface and the underground workings indicate that the ore deposits are small but high in grade.
A Multi-Institutional Phase 2 Trial of Ablative 5-Fraction Stereotactic Magnetic Resonance-Guided On-Table Adaptive Radiation Therapy for Borderline Resectable and Locally Advanced Pancreatic Cancer (2023)

The primary endpoint of this study was met with no acute grade ≥3 GI toxicity definitely attributed to ablative 5-fraction SMART. Although it is unclear whether SMART contributed to postoperative toxicity, we recommend caution when pursuing surgery, especially with vascular resection after SMART. Additional follow-up is ongoing to evaluate late toxicity, quality of life, and long-term efficacy.
How Do Actinyls Interact with Hyperphosphorylated Yolk Protein Phosvitin? (2019)

The development of the nuclear industry has raised multiple questions about its impact on the biotope and humans. Proteins are key biomolecules in cell machinery and essential in deciphering toxicological processes. Phosvitin was chosen as a relevant model for phosphorylated proteins because of its important role as an iron, calcium, and magnesium storage protein in egg yolk. A multitechnique spectroscopic investigation was performed to reveal the coordination geometry of two oxocations of the actinide family (actinyl U<sup>VI</sup> , Np<sup>V</sup> ) in speciation with phosvitin. IR spectroscopy revealed phosphoryl groups as the main functional groups interacting with U<sup>VI</sup> . This was confirmed through laser luminescence spectroscopy (U) and UV/Vis absorption spectroscopy (Np). For U<sup>VI</sup> , X-ray absorption spectroscopy at the L<sub>III</sub> edge revealed a small contribution of bidentate binding present, along with predominantly monodentate binding of phosphoryl groups; for Np<sup>V</sup> , uniquely bidentate binding was revealed. As a perspective to this work, X-ray absorption spectroscopy speciation of U<sup>VI</sup> and Np<sup>V</sup> in the extracted yolk of living eggs of the dogfish Scyliorhinus canicula was determined; this corroborated the binding of phosphorous together with a reduction of the actinyl moiety. Such data are essential to pinpoint the mechanisms of heavy metals (actinyls) accumulation and toxicity in oviparous organisms, and therefore, contribute to a shift from descriptive approaches to predictive toxicology.
UV second harmonic generation in AlN waveguides with modal phase matching (2016)

AlN waveguides on sapphire substrates were fabricated from AlN films grown by metalorganic chemical vapor deposition. By tuning the wavelength of the pump light we demonstrated a second harmonic generation in the UV at 306, 331, and 356 nm using the d33 coefficient and modal dispersion phase matching (MDPM). A theoretical model for MDPM with two- and three-mode interaction in planar waveguides was used to explain the results. Its essential component describes the interaction of two, possibly different, waveguide modes at the fundamental frequency that excite the third mode at doubled frequency. The experimental results were found to agree well with the theoretical model. This work confirmed the application potential of high-quality AlN films as waveguides for nonlinear processes.
Wafer-level adaptive trim seed forecasting based on E-tests (2017)

Post silicon trimming is extensively used to counter the effects of manufacturing process variation on certain critical electrical parameters of an integrated circuit (IC). Usually, trimming is performed iteratively by adjusting the resistance value of a trim circuit to specific discrete values. Test programs represent those values by codes and apply common search algorithms in order to find a code which makes a device (optimally) compliant to its design specifications. Consequently, manufacturing yield is increased significantly, yet at the expense of added test time and complexity. In this work, we introduce a novel methodology wherein a trained multivariate model is used to predict, adaptively for each wafer, the optimal starting point of the algorithm that searches for the trim code. Thereby, we seek to minimize the number of code changes that the search algorithm has to perform and, by extension, the overall trim time. In order to provide this prediction prior to wafer sort, so that simplicity of test-floor logistics does not get compromised, the predictive model is built using electrical test (e-test) measurements, which are available before wafer sort, and is trained through measurements from a set of early wafers. Effectiveness of the proposed method in reducing trim time is demonstrated on 370 wafers of an high performance device manufactured by Texas Instruments.
Aligning Distant Sequences to Graphs using Long Seed Sketches (2022)

Abstract Sequence-to-graph alignment is an important step in applications such as variant genotyping, read error correction and genome assembly. When a query sequence requires a substantial number of edits to align, approximate alignment tools that follow the seed-and-extend approach require shorter seeds to get any matches. However, in large graphs with high variation, relying on a shorter seed length leads to an exponential increase in spurious matches. We propose a novel seeding approach relying on long inexact matches instead of short exact matches. We demonstrate experimentally that our approach achieves a better time-accuracy trade-off in settings with up to a 25% mutation rate. We achieve this by sketching a subset of graph nodes and storing them in a K -nearest neighbor index. While sketches are more robust to indels, finding the nearest neighbor of a sketch in a high-dimensional space is more computationally challenging than finding exact seeds. We demonstrate that if we store sketch vectors in a K -nearest neighbor index, we can circumvent the curse of dimensionality. Our long sketch-based seed scheme contrasts existing approaches and highlights the important role that tensor sketching can play in bioinformatics applications. Our proposed seeding method and implementation have several advantages: i) We empirically show that our method is efficient and scales to graphs with 1 billion nodes, with time and memory requirements for preprocessing growing linearly with graph size and query time growing quasi-logarithmically with query length. ii) For queries with an edit distance of 25% relative to their length, on the 1 billion node graph, longer sketch-based seeds yield a 4× increase in recall compared to exact seeds. iii) Conceptually, our seeder can be incorporated into other aligners, proposing a novel direction for sequence-to-graph alignment. The implementation is available at: https://github.com/ratschlab/tensor-sketch-alignment .
<title>Network traffic modeling using connection-level information</title> (2002)

Aggregate network traffic exhibits strong burstiness and non-Gaussian distributions, which popular models such as fractional Gaussian noise (fGn) fail to capture. To better understand the cause of traffic burstiness, we investigate the connection-level information of traffic traces. A careful study reveals that traffic burstiness is directly related to the heterogeneity in connection bandwidths and round-trip times and that a small number of high-bandwidth connections are solely responsible for bursts. This separation of connections has far-reaching implications on network control and leads to a new model for network traffic which we call the alpha/beta model. In this model, the network traffic is composed of two components: a bursty, non-Gaussian alpha component (stable Levy noise) and a Gaussian, long range dependent beta component (fGn). We present a fast scheme to separate the alpha and beta components of traffic using wavelet denoising.
Power reduction through work reuse [superscalar processor microarchitecture] (2002)

Power consumption has become one of the big challenges in designing high performance processors. The rapid increase in complexity and speed that comes with each new CPU generation causes greater problems with power consumption and heat dissipation. Traditionally, these concerns are addressed through semiconductor technology improvements such as voltage reduction and technology scaling. This work proposes an alternative solution to this problem, by dealing with the power consumption in the very early stage of the microarchitecture design. More precisely, we show that by modifying the well-established out-of-order, superscalar processor architecture, significant gains can be achieved in terms of power requirements without performance penalty. Our proposed approach relies on reusing as much as possible from the work done by the front-end of a typical pipelined, superscalar out-of-order via the use of a cache nested deeply into the processor structure. Experimental results show up to 52% (20% on average) savings in average energy per committed instruction for two different pipeline structures.
‘Stranger Danger’ and the Gendered/Racialised Construction of Threats in Humanitarianism (2020)

Humanitarian, development and peacebuilding work has become increasingly dangerous in recent decades. The securitisation of aid has been critiqued, alongside the racialised and gendered dynamics of security provision for aid actors. What has received less attention is how a range of intersectional marginalisations – gender, racialisation, sexuality, nationality and disability – play out in constructions of security, danger and fear in aid deployments. Focusing on sexual harassment, abuse and violence as threats to safety and security, the article examines how in training and guidance for deployment to ‘the field’ (itself a problematically securitised notion), danger is projected onto sexualised and racialised ‘locals’, often overlooking the potentially far greater threat from colleagues. Here, we employ a review of security guidance, social media groups, interviews with aid staffers and reflections on our own experiences to explore how colonialist notions of security and ‘stranger danger’ play out in training. We argue that humanitarianism is still dominated by the romanticised figure of the white, male humanitarian worker – even if this problematic imaginary no longer reflects reality – and a space where those questioning exclusionary constructs of danger are quickly silenced and even ridiculed, even in the age of #MeToo and #BlackLivesMatter.
Automatic multiple threshold scheme for segmentation of tomograms (2007)

Tomographic reconstructions, which are generally gray-scale images, are often segmented as to extract quantitative information, such as the shape or volume of image objects. At present, segmentation is usually performed by thresholding. However, the process of threshold selection is somewhat arbitrary and requires human interaction. In this paper, we present an algorithmic approach for automatically selecting the segmentation thresholds by using the available tomographic projection data. Assuming that each material (i.e., tissue type) in the sample has a characteristic, approximately constant gray value, thresholds are computed for which the segmented image corresponds optimally with the projection data.
7.5 Gb/s monolithically integrated clock recovery circuit using PLL and 0.3-/spl mu/m gate length quantum well HEMT's (1994)

A monolithically integrated clock recovery (CR) circuit making use of the phase-locked loop (PLL) circuit technique and enhancement/depletion AlGaAs/GaAs quantum well-high electron mobility transistors (QW-HEMT's) with gate lengths of 0.3 /spl mu/m has been realized. A novel preprocessing circuit was used. In the PLL a fully-balanced varactorless VCO was applied. The VCO has a center oscillating frequency of about 7.7 GHz and a tuning range greater than 500 MHz. A satisfactory clock signal has been obtained at a bit rate of about 7.5 Gb/s. The power consumption is less than 200 mW at a supply voltage of -5 V.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Treatment Thresholds for Stink Bugs (Hemiptera: Pentatomidae) in Cotton (2001)

The green stink bug, Acrosternum hilare (Say), the southern green stink bug, Nezara viridula (L), and the brown stink bug, Euschistus servus (Say), were predominant phytophagous Pentatomidae detected during 1995-1997 in cotton in South Carolina. These species occurred in similar numbers in conventional and transgenic cotton 'NuCOTN33B', containing the gene for expression of CryIA(c) delta-endotoxin of Bacillus thuringiensis Berliner variety kurstaki. Adult stink bugs moved into cotton from wild and cultivated alternate hosts during July, and reproducing populations usually were detected in cotton from late July into September. Applications of either methyl parathion (0.56 kg [AI]/ha) directed for stink bugs or lambda-cyhalothrin (0.037 kg [AI]/ha) or cyfluthrin (0.056 kg [AI]/ha) for control of cotton bollworm, Helicoverpa zea (Boddie), provided effective control of pentatomids in NuCOTN33B or conventional 'DP5415' and increased yields compared with untreated plots. Fiber quality did not differ among treated or untreated plots of NuCOTN33B. The ground-cloth technique was used to estimate populations of stink bugs, and data indicated that treatment at one bug per 2 m of row adequately protected cotton from yield loss due to stink bug damage. Observations on boll damage indicated that treatment might be necessary if >20-25% reveal internal symptoms of feeding injury during mid- to late season. More detailed damage thresholds should be developed to complement an approach based on population monitoring. This study validated current recommendations for management of pentatomids in cotton, demonstrated the necessity of threshold use for stink bugs in transgenic cultivars expressing endotoxin from B. thuringiensis, and provided insight into further development of management options for pentatomids in the crop.