gebhart/patrepeval huggingface dataset:
Paclitaxel in germ cell cancer. (1995)

The teratocarcinoma cell line 833K and its relatively cisplatin-resistant subline 833K/63CP 10 were used to assess the cytotoxicity of paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ), cisplatin, and 4-hydroxyperoxycyclophosphamide quantitatively. The results showed that paclitaxel had marked cytotoxicity against teratocarcinoma, particularly in the cells that were relatively cisplatin resistant. These studies suggested synergy in cytotoxicity for paclitaxel, cisplatin, and 4-hydroxyperoxycyclophosphamide. A phase II trial of paclitaxel was conducted in patients with previously treated germ cell tumors with restricted prior treatment. The paclitaxel dose was 250 mg/m2 given by 24-hour continuous infusion. In 31 patients treated with paclitaxel, eight (26%) achieved a major (complete or partial) response. The antitumor activity of paclitaxel in the phase II trial has led us to further study it as a part of combination therapy. Since the in vitro studies showed synergistic cytotoxicity, combination studies of paclitaxel, ifosfamide, and platinum are under way as salvage treatment for patients with germ cell tumors.
A 200 MHz 2.5 V 4 W superscalar RISC microprocessor (2002)

This RISC microprocessor is based on a microarchitecture designed in a 2.5 V CMOS technology. The 78.75 mm/sup 2/ design features dual 16 kB instruction and data caches, a floating-point unit, an integer unit, a branch unit, a load/store unit, and a system unit. Two instructions per cycle can be dispatched in this superscalar design. The user-configurable multiplying PLL provides a processor clock at 2/spl times/, 2.5/spl times/, 3/spl times/, 3.5/spl times/, 4/spl times/, 4.5/spl times/, 5/spl times/, 5.5/spl times/, and 6/spl times/ the bus clock frequency. Testability features include level-sensitive-scan-design (LSSD), array-built-in-self-test (ABIST) logic for cache and tag arrays, and a JTAG interface.
Spine surgery core curriculum : a review of competencies in subspecialty Fellowship Training (2014)

Objective: To evaluate fellowship trainee and supervisor perceptions on the relative importance of core cognitive and procedural competencies in spine subspecialty fellowship training. Summary of Background Data: At present, there is no formalized curriculum for spine fellowship training in North America. There have been many recent advances in surgical residency education and similar interest exists in fellowship education. Specifically, there has been a trend towards the standardization and formalization of spine surgery subspecialty training. The purpose of this study was to identify core cognitive and technical competencies required for successful spine fellowship training in order to facilitate the future development of a standardized curriculum for spine surgery.
Characterization of humic acids extracted from biosolid amended soils (2014)

The aim of this study was to evaluate the changes produced in the chemical, acid-base and structural properties of soil amended (biosolids) and humic acids HAs incubated at different times.
Gas1 inhibits cell proliferation and induces apoptosis of human primary gliomas in the absence of Shh (2009)

Growth arrest specific1 (Gas1) is a protein expressed during development and when cells arrest their growth. The potential of Gas1 as an adjuvant in the treatment of cancer, and its role as a tumor suppressor have also been proposed. In this work we are addressing the molecular mechanisms by which Gas1 induces cell arrest and apoptosis of cancer cells, using primary cultures of human gliomas as a model. We had previously demonstrated the structural relationship between Gas1 and the alpha receptors for the Glial-cell line-Derived Neurotrophic Factor (GDNF) family of ligands, and showed that Gas1 acts by inhibiting the intracellular signaling induced by GDNF. There are also reports indicating that Gas1 positively cooperates with Sonic Hedgehog (Shh) during embryonic development and in this paper we analyzed the potential interactions between Gas1 and Shh. We show that human gliomas do not express Shh, whereas GDNF and the molecular components necessary to transduce its signaling are present in human gliomas. Furthermore, the over-expression of Gas1 induces cell arrest, apoptosis and prevents the activation of Akt, a crucial mediator of survival and cellular proliferation pathways. In the present work, we present evidence demonstrating that Gas1 exerts its effects inhibiting cell growth and inducing apoptosis of glioma cells in the absence of Shh.
Rapid identification of primary constituents in parotoid gland secretions of the Australian cane toad using HPLC/MS‐Q‐TOF (2013)

Toad parotoid gland secretion or toad venom has in recent years been increasingly shown to possess potentially beneficial pharmacological effects; this speculation has drawn much interest centred on elucidating the chemical basis of its multimodal effects. For this purpose, we explored the use of a rapid and accurate analysis method for systemic investigation of the parotoid gland chemistry, when extracted from Australian cane toads. Full-scan data of cane toad venom extract was acquired using high-performance liquid chromatography coupled with a hybrid quadrupole-time of flight mass spectrometry system (HPLC/MS-Q-TOF), with multiple ionization sources (ESI and APCI) in positive and negative mixed modes. By measuring the exact mass differences between the theoretical and measured mass of each assumed compound, we confirmed the presence of 12 key constituents. The present results demonstrate that the use of HPLC/MS-Q-TOF with multiple ionization sources delivers exemplary selectivity and sensitivity, allowing for the rapid and accurate identification of constituents within cane toad venom. This paves the way for this technique to be used in future routine screening of components within the genus Bufo and for key analytes too, then reliably assessed for any purported beneficial (clinic) properties.
<b>Upregulation of energy metabolism-related, p53-target TIGAR and SCO2 in HuH-7 cells with p53 mutation by geranylgeranoic acid tr</b><b>eatment </b> (2015)

Metabolic alternation in cancer cells is one of the most common characteristics that distinguish malignant cells from normal cells. Many studies have explained the Warburg hypothesis that cancer cells obtain more energy from aerobic glycolysis than mitochondrial respiration. Here, we show that a branched-chain C-20 polyunsaturated fatty acid, geranylgeranoic acid (GGA), induces upregulation of the cellular protein levels of TP53-induced glycolysis and apoptosis regulator (TIGAR) and synthesis of cytochrome c oxidase 2 (SCO2) in human hepatoma-derived HuH-7cells harboring the mutant TP53 gene, suggesting that GGA may shift an energetic state of the tumor cells from aerobic glycolysis to mitochondrial respiration. In addition, UPLC/TOF/MS-based metabolomics analysis supported the GGA-induced energetic shift, as it revealed that GGA induced a time-dependent increase in the cellular contents of fructose 6-phosphate and decrease of fructose 1,6-diphosphate. Furthermore, metabolomics analysis revealed that GGA rapidly induced spermine accumulation with slight decrease of spermidine. Taken together, the present study strongly suggests that GGA may shift HuH-7 cells from aerobic glycolysis to mitochondrial respiration through the immediate upregulation of TIGAR and SCO2 protein levels.
ChemInform Abstract: Synthesis and Biological Properties of the Four Optical Isomers of 5‐o‐Carboranyl‐2′,3′‐didehydro‐2′,3′‐dideoxyuridine. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
<title>Image Acquisition, Processing And Display</title> (1979)

Image capture with a combination of video camera, digital-to-analog converter and digital video processor is described. Techniques for facilitating camera calibration are addressed. Followed by discussion of reference and sample data capture. Physical registration methods using real-time difference images are considered. Capabilities for functional manipulation, reference correction and multiple frame integration are elaborated with examples. Representative post-acquisition processing operations are outlined.
A sensitivity correction method for a three-dimensional sound intensity probe. (2000)

The upper frequency limit of a p-p type sound intensity probe is mostly determined by the sensitivity reduction of the probe.The sensitivity reduction is caused by obtaining the pressure from the average of the two pressure signals including the phase, and by obtaining the particle velocity from the finite difference of the two pressure signals.This is a systematic error suggesting a possibility of correction.In order to compensate or correct the sensitivity reduction, the direction of energy flow must be known.If a one-dimensional intensity probe is used, the probe direction must be varied to find the direction of the energy flow.If a three-dimensional intensity probe is used, the direction of the energy flow can be at least roughly estimated from a single measurement and then the sensitivity reduction can be corrected.This paper proposes a method of sensitivity reduction correction in the high frequency region for a three-dimensional(3-D)intensity probe.A theory of the method is described first and then numerical results that validate the theory will be given.This method works even for a probe with some amount of phase mismatch among microphones and for a sound field with reflections.
Structural Characterization of N‐Linked Oligosaccharides from Cellobiohydrolase I Secreted by the Filamentous Fungus Trichoderma Reesei RUTC 30 (1997)

We have characterized the primary structures of the predominant N-linked oligosaccharides on cellobiohydrolase I from the filamentous fungus Trichoderma reesei RUTC30. Different enzymatic and chromatographic techniques were used to analyze six oligosaccharides. The combined data showed that the fungal carbohydrates have a core structure that is identical to the mammalian N-linked core. In the bulk of the N-glycans, the alpha-1,3 arm is extended with two mannoses and a glucose, suggesting incomplete processing of the oligosaccharides in the endoplasmic reticulum. The alpha-1,6 arm shows a remarkable heterogeneity: in addition to alpha-1,2-Man and alpha-1,6-Man, the presence of a terminal mannose alpha-1,6-phosphodiester was observed. This latter substituent has not been characterized before on mannosidase-processed N-glycan and its function and synthesis pathway are entirely unknown. The predominant N-glycans on cellobiohydrolase I can be represented as follows: GlcMan8GlcNAc2, GlcMan7GlcNAc2, Man7GlcNAc2, ManPGlcMan7GlcNAc2, GlcMan5GlcNAc2 and Man5GlcNAc2.
Comparative analysis on meteorological parameters of sounding data and model-generated sounding data (2012)

By using the NCEP/NCAR global reanalysis data with sounding observation data over Fuyang and Anqing from Nov.of 2007 to Nov.of 2008,we compared and analyzed the data consistency between two sets of data based on the Lagrange interpolation in vertical direction and horizontal bilinear interpolation of NCEP data.The results showed that the absolute errors of temperature,relative humidity,u wind and v wind between these two data changed a little in different locations,heights and seasons.The range of meteorological parameters absolute error(0.5-8 km) was as follows: 0.5-1.0 degree(temperature),5%-15%(relative humidity),1-3 m/s(u wind),1-4 m/s(v wind),which is relatively stable,so that NCEP data can be used to analyze the characteristic of meteorological parameters in areas without observational data.However,the absolute error close to the ground is larger than that from 0.5 km to 8 km.
Nanostructured MgO binders for thermal battery separators. (2016)

Abstract not provided.
Synthesis of 4,4‐Disubstituted 2‐Aminocyclopentanecarboxylic Acid Derivatives and Their Incorporation into 12‐Helical β‐Peptides. (2005)

An enantioselective synthetic route is reported for &lt;i&gt;trans&lt;/i&gt;-2-aminocyclopentanecarboxylic acids (ACPC) bearing geminal side chain pairs at the\n4-position. β-Peptides containing the 4,4-disubstituted ACPC residues adopt the 12-helical conformation, as demonstrated by 2D NMR analysis\nin aqueous solution. These 4,4-disubstituted ACPC residues display functional groups, including acidic and hydrogen bond donating groups,\nin a geometrically defined fashion, which should be useful for the design of β-peptides for specific applications.
Stage-specific habitats of Calanus finmarchicus and Calanus helgolandicus in a stratified northern Norwegian fjord (2000)

During 12 months from April 1997, Calanus spp. copepodites were sampled in the 380-m deep Saltfjord by means of a 200-μm WP-2 net at four depth intervals. Nauplii were sampled with a 100-μm bongo net. Chlorophyll a and phytoplankton were sampled with a hose in the 0–40 m depth range. Environmental variables were recorded by CTD and an in situ fluorimeter. C. helgolandicus occurred in low numbers as adults and CV during most of the year. During the spring bloom in April, it avoided the upper cold 0–50 m depth range, where C. finmarchicus reproduced. In August–September, adults of the two species were equally numerous in the 0–50 m depth range. The adult C. finmarchicus had probably developed from the local spring generation, whereas C. helgolandicus had probably been imported from shelf waters. Nauplii present in August may be attributed to both species, but they did not grow into CI locally. Therefore, C. finmarchicus CV that accumulated in September–October were more likely imported from the shelf, probably by surface advection. Predators possibly reduced numbers up to January 1998, when both species again increased, probably because of deep inflow of shelf water.
Comorbidity of inflammatory bowel disease in children and adolescents with type 1 diabetes (2020)

Although children and adolescents with T1D and IBD take steroids more often, they suffer from severe hypoglycaemia more frequently and have a lower BMI-SDS. These findings might be explained by chronic intestinal inflammation leading to malabsorption, malnutrition and increased severe hypoglycaemia.
Influence of Microwave Heating on LiquidLiquid Phase Inversion and Temperature Rates for Immiscible Mixtures (2011)

Time dependencies of component temperatures for mixtures of immiscible liquids during microwave heating were studied for acetonitrile-cyclohexane and water-toluene. For the first time, we report microwave induced liquid-liquid phase inversion for acetonitrile-cyclohexane mixture: acetonitrile layer was initially at the bottom of the mixture, after 10 sec of microwave heating its density decreased and it inverted to the top of the mixture for the remainder of the microwave heating. This phase inversion could not be achieved by conventional radiant heating. The maximum rate of temperature growth for the polar component of the mixtures was 2 - 5 times larger than for the non-polar component. This suggests that microwave energy is absorbed by polar liquids (water or acetonitrile) and heat is transferred into the non-polar liquid (toluene or cyclohexane) in the mixture by conduction (in case of cyclohexane) or conduction and convection (in case of toluene). Comparison between experimental data and semi-empirical mathematical models, proposed in [Kennedy et at., 2009] showed good correlation. Average relative error between theoretical and experimental results did not exceed 7%. These results can be used to model the temperature kinetics of components for other multiphase mixtures.
High Energy Gap OLED Host Materials for Green and Blue PHOLED Materials (2009)

In this paper, we developed a series of novel arylamino-containing spiro triplet state host materials for green and blue phosphorescent emitters. With high enough energy gap and compatible HOMO, LUMO levels, we demonstrated the green PHOLED with a low driving voltage of 2.5 V and a high power efficiency of 38.5 lm/W. We also demonstrated blue PHOLED with a very low driving voltage of 3.0 V and a current efficiency of 9.2 cd/A.
Reputation Attacks Detection for Effective Trust Assessment among Cloud Services (2013)

Consumers' feedback is a good source to help assess overall trustworthiness of cloud services. However, it is not unusual that a trust management system experiences malicious behaviors from its users (i.e., collusion or Sybil attacks). In this paper, we propose techniques for the detection of reputation attacks to allow consumers to effectively identify trustworthy cloud services. We introduce a credibility model that not only identifies misleading trust feedbacks from collusion attacks but also detects Sybil attacks, either strategic (in a long period of time) or occasional (in a short period of time). We have collected a large collection of consumer's trust feedbacks given on real-world cloud services (over 10, 000 records) to evaluate and demonstrate the applicability of our approach and show the capability of detecting such malicious behaviors.
Temporal bone: comparison of isotropic helical CT and conventional direct axial and coronal CT. (1999)

Helical CT using 0.5-mm technique and reconstruction produces diagnostic images comparable with or superior to conventional 1-mm technique because helical CT can obtain thinner slices.
Cloning of a Complementary DNA that Encodes an Acidic Chitinase which is Induced by Ethylene and Expression of the Corresponding Gene (1993)

A complementary DNA encoding an ethylene-inducible acidic chitinase of azuki bean (Vigna angularis) was isolated, and its complete nucleotide sequence was determined. The nucleotide and deduced amino-acid sequence were very similar to those of an acidic chitinase from cucumber leaves that had been infected with tobacco necrosis virus. The mRNA for the acidic chitinase was not detected in leaves of azuki bean that had not been treated with ethylene, but it appeared 3 h after initiation of treatment with ethylene and its level gradually increased over a period of 19 h. The mRNA also accumulated in response to salicylate or wounding. The expression of the gene in response to wounding was suppressed by 2,5-norbornadiene, but that in response to salicylate was not affected by this inhibitor.
Design of autonomous photovoltaic power plant for telecommunication relay station (2005)

The design and prototyping of an autonomous photovoltaic power generation system using the Virtual Test Bed software environment is presented. The comprehensive design of the photovoltaic power plant is very important for achieving the best performance, durability and reliability of the system. The goal of the design is to optimise the system performance by accounting for various data available at the design time. These data may include statistical data of weather conditions at particular geographic locations, the statistics of the load profiles and, finally, the projected outlook of the system use. The design of the autonomous photovoltaic power system presented in this work includes establishing physics-based models for components, prototyping system architectures, implementing control algorithms, testing and evaluating the system performance using the actual weather data at a particular geographical location. The dynamic performance of the photovoltaic power system and its components are revealed in great detail through the system-level simulation. This knowledge is used for verification and improvements of the system design in order to achieve the best system power capability, efficiency and size.
Prediction of seismic cracking capacity of glazing systems (2015)

This research formulates a closed-form equation to predict a glass panel cracking failure drift for several curtain wall and storefront systems. An evaluation of the ASCE 7-10 equation for Dclear, which is the drift corresponding to glass-to-frame contact, shows that the kinematic modeling assumed for formulation of the equation is sound. The equation proposed in this paper builds on the ASCE equation and offers a revision of that equation to predict drift corresponding to cracking failure by considering glazing characteristics such as glass type, glass panel configuration, and system type. The formulation of the proposed equation and corresponding analyses with the ASCE equation is based on compiled experimental data of twenty-two different glass systems configurations tested over the past decade. A final comparative analysis between the ASCE equation and the proposed equation shows that the latter can predict the drift corresponding to glass cracking failure more accurately.
Agents and Databases: Friends or Foes? (2006)

On first glance agent technology seems more like a hostile intruder into the database world. On the other hand, the two could easily complement each other, since agents carry out information processes whereas databases supply information to processes. Nonetheless, to view agent technology from a database perspective seems to question some of the basic paradigms of database technology, particularly the premise of semantic consistency of a database. The paper argues that the ensuing uncertainty in distributed databases can be modelled by beliefs, and develops the basic concepts for adjusting peer-to-peer databases to the individual beliefs in single nodes and collective beliefs in the entire distributed database.
Design of Robot Safe Working Strategy Based on Laser Sensor (2018)

Aiming at the security problem of cooperative robot, this article introduces a kind of robot safe working strategy based on laser radar sensor to ensure the safety of the robot in working space. Firstly, the laser sensor is used to detect the moving objects around the robot (including people) and Kalman Filter is used to forecast the position of the tracking object by the obtained scanning data. Then, according to the distance between the moving object and the robot, the safety operation level of the manipulator is determined. Finally, the robot takes different measures to ensure the safety based on the safety level. This strategy is simulated by V-REP and the results show that the scheme can effectively guarantee the safety of robot operation.
Editorial: Neurogenic Bladder (1994)

No AccessJournal of Urology1 Dec 1994Editorial: Neurogenic Bladder Rodney A. Appell Rodney A. AppellRodney A. Appell More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)32315-7AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Editorial: Neurogenic Bladder." The Journal of Urology, 152(6 Part 1), p. 2086 © 1994 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 152Issue 6 Part 1December 1994Page: 2086 Advertisement Copyright & Permissions© 1994 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Rodney A. Appell More articles by this author Expand All Advertisement Loading ...
The Evolution of PA Linearization: From Classic Feedforward and Feedback Through Analog and Digital Predistortion (2016)

This article reviews the history and concepts behind the linearizers in use today. Predistortion linearization is by far the most widely used form of linearization and is most commonly generated digitally (DPD) for use in telecommunications and relatively limited bandwidth applications. The future for DPD looks bright, with new developments in software and hardware and exciting opportunities for disruptive approaches to be successful. For wider bandwidths, analog predistortion is often used. Rapid progress is being made to produce linearizers of very wide bandwidth and to extend their capabilities to the upper millimeter-wave bands. Multi-octave analog predistorters with greater than 10 GHz of bandwidth and that operate to 100 GHz have been produced.