gebhart/patrepeval huggingface dataset:
Evaluation of plasma-free endocannabinoids and their congeners in abstinent cocaine addicts seeking outpatient treatment: impact of psychiatric co-morbidity (2013)

Cocaine is associated with serious health problems including psychiatric co-morbidity. There is a need for the identification of biomarkers for the stratification of cocaine-addicted subjects. Several studies have evaluated circulating endocannabinoid-related lipids as biomarkers of inflammatory, metabolic and mental disorders. However, little is known in substance use disorders. This study characterizes both free N-acyl-ethanolamines (NAEs) and 2-acyl-glycerols in abstinent cocaine addicts from outpatient treatment programs who were diagnosed with cocaine use disorder (CUD; n = 88), and age-/gender-/body mass-matched healthy control volunteers (n = 46). Substance and mental disorders that commonly occur with substance abuse were assessed by the semi-structured interview 'Psychiatric Research Interview for Substance and Mental Diseases' according to the 'Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision' (DSM-IV-TR) and plasma-free acyl derivatives were quantified by a liquid chromatography-tandem mass spectrometry system. The results indicate that plasma acyl derivatives are altered in abstinent cocaine-addicted subjects with CUD (CUD subjects). While NAEs were found to be increased, 2-acyl-glycerols were decreased in CUD subjects compared with controls. Multivariate predictive models based on these lipids as explanatory variables were developed to distinguish CUD subjects from controls providing high discriminatory power. However, these alterations were not influenced by the DSM-IV-TR criteria for cocaine abuse and dependence as cocaine trait severity measure. In contrast, we observed that some free acyl derivatives in CUD subjects were found to be affected by the diagnosis of some co-morbid psychiatric disorders. Thus, we found that the monounsaturated NAEs were significantly elevated in CUD subjects diagnosed with mood [N-oleoyl-ethanolamine and N-palmitoleoyl-ethanolamine (POEA)] and anxiety (POEA) disorders compared with non-co-morbid CUD subjects. Interestingly, the coexistence of alcohol use disorders did not influence the circulating levels of these free acyl derivatives. In summary, we have identified plasma-free acyl derivatives that might serve as reliable biomarkers for CUD. Furthermore, we found that monounsaturated NAE levels are also enhanced by co-morbid mood and anxiety disorders in cocaine addicts. These findings open the way for the development of new strategies for cocaine addiction diagnosis and treatment.
Mirror devices (1990)

Abstract The present survey will cover some results obtained during the past few years. The paper is organized as follows. In Section 2 some recent results of the mirror physics are presented. Section 3 is devoted to mirror-based neutron sources. Section 4 describes one possible version of a D3He mirror reactor. Finally, Section 5 contains some conclusions. The mirrors are the only topologically different alternative to tokamaks and thus could give rise to a fusion reactor that will have quite different and, hopefully, attractive properties among which there will be much higher betas and inherent stationarity.
Antibacterial Properties of Propolis (Bee Glue) (1990)

Propolis (bee glue) was found to have antibacterial activity against a range of commonly encountered cocci and Gram-positive rods, including the human tubercle bacillus, but only limited activity against Gram-negative bacilli. These findings confirm previous reports of antimicrobial properties of this material, possibly attributable to its high flavonoid content.
Direct numerical simulation of premixed flame boundary layer flashback in turbulent channel flow (2012)

Abstract Direct numerical simulations are performed to investigate the transient upstream propagation (flashback) of premixed hydrogen–air flames in the boundary layer of a fully developed turbulent channel flow. Results show that the well-known near-wall velocity fluctuations pattern found in turbulent boundary layers triggers wrinkling of the initially flat flame sheet as it starts propagating against the main flow direction, and that the structure of the characteristic streaks of the turbulent boundary layer ultimately has an important impact on the resulting flame shape and on its propagation mechanism. It is observed that the leading edges of the upstream-propagating premixed flame are always located in the near-wall region of the channel and assume the shape of several smooth, curved bulges propagating upstream side by side in the spanwise direction and convex towards the reactant side of the flame. These leading-edge flame bulges are separated by thin regions of spiky flame cusps pointing towards the product side at the trailing edges of the flame. Analysis of the instantaneous velocity fields clearly reveals the existence, on the reactant side of the flame sheet, of backflow pockets that extend well above the wall-quenching distance. There is a strong correspondence between each of the backflow pockets and a leading edge convex flame bulge. Likewise, high-speed streaks of fast flowing fluid are found to be always colocated with the spiky flame cusps pointing towards the product side of the flame. It is suggested that the origin of the formation of the backflow pockets, along with the subsequent mutual feedback mechanism, is due to the interaction of the approaching streaky turbulent flow pattern with the Darrieus–Landau hydrodynamic instability and pressure fluctuations triggered by the flame sheet. Moreover, the presence of the backflow pockets, coupled with the associated hydrodynamic instability and pressure–flow field interaction, greatly facilitate flame propagation in turbulent boundary layers and ultimately results in high flashback velocities that increase proportionately with pressure.
Synthesis of aminoethyl derivatives of .alpha.,.omega.-alkylenediamines and structure-activity relations for the polyamine-bovine plasma amine oxidase system (1971)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of aminoethyl derivatives of .alpha.,.omega.-alkylenediamines and structure-activity relations for the polyamine-bovine plasma amine oxidase systemMervyn Israel and Edward J. ModestCite this: J. Med. Chem. 1971, 14, 11, 1042–1047Publication Date (Print):November 1, 1971Publication History Published online1 May 2002Published inissue 1 November 1971https://pubs.acs.org/doi/10.1021/jm00293a005https://doi.org/10.1021/jm00293a005research-articleACS PublicationsRequest reuse permissionsArticle Views221Altmetric-Citations11LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
High Density Mapping of Quantitative Trait Loci Conferring Gluten Strength in Canadian Durum Wheat (2020)

Gluten strength is one of the factors that determine the end-use quality of durum wheat and is an important breeding target for this crop. To characterize the quantitative trait loci (QTL) controlling gluten strength in Canadian durum wheat cultivars, a population of 162 doubled haploid (DH) lines segregating for gluten strength and derived from cv. Pelissier × cv. Strongfield was used in this study. The DH lines, parents, and controls were grown in 3 years and two seeding dates in each year and gluten strength of grain samples was measured by sodium dodecyl sulfate (SDS)-sedimentation volume (SV). With a genetic map created by genotyping the DH lines using the Illumina Infinium iSelect Wheat 90K SNP (single nucleotide polymorphism) chip, QTL contributing to gluten strength were detected on chromosome 1A, 1B, 2B, and 3A. Two major and stable QTL detected on chromosome 1A (<i>QGlu.spa-1A</i>) and 1B (<i>QGlu.spa-1B.1</i>) explaining 13.7-18.7% and 25.4-40.1% of the gluten strength variability respectively were consistently detected over 3 years, with the trait increasing alleles derived from Strongfield. Putative candidate genes underlying the major QTL were identified. Two novel minor QTL (<i>QGlu.spa-3A.1</i> and <i>QGlu.spa-3A.2</i>) with the trait increasing allele derived from Pelissier were mapped on chromosome 3A explaining up to 8.9% of the phenotypic variance; another three minor QTL (<i>QGlu.spa-2B.1</i>, <i>QGlu.spa-2B.2</i>, and <i>QGlu.spa-2B.3</i>) located on chromosome 2B explained up to 8.7% of the phenotypic variance with the trait increasing allele derived from Pelissier. <i>QGlu.spa-2B.1</i> is a new QTL and has not been reported in the literature. Multi-environment analysis revealed genetic (QTL) × environment interaction due to the difference of effect in magnitude rather than the direction of the QTL. Eleven pairs of digenic epistatic QTL were identified, with an epistatic effect between the two major QTL of <i>QGlu.spa-1A</i> and <i>QGlu.spa-1B.1</i> detected in four out of six environments. The peak SNPs and SNPs flanking the QTL interval of <i>QGlu.spa-1A</i> and <i>QGlu.spa-1B.1</i> were converted to Kompetitive Allele Specific PCR (KASP) markers, which can be deployed in marker-assisted breeding to increase the efficiency and accuracy of phenotypic selection for gluten strength in durum wheat. The QTL that were expressed consistently across environments are of great importance to maintain the gluten strength of Canadian durum wheat to current market standards during the genetic improvement.
World Science Report 1996 (1996)

The new edition of this important periodic publication from UNESCO reviews and updates the state of science and technology around the world. It describes and quantifies the recent trends in scientific education and research and development and addresses many of the specific problems faced by each region or group of countries. Some of the most important issues in science and technology of the last few years, of interest both to the scientific community and to society at large, are discussed in the second part of the book. Among these are biodiversity, environmental degradation, the ethics of science and international cooperation in megascience. Particular attention is accorded to recent developments in the new technologies and their impact on society, with chapters on information technology, biotechnology and materials sciences and engineering. The final part is devoted to the gender dimension of science and technology. Its authors, making use of a wide variety of sources, describe the existing disparity in this field, and analyse the main social and educational barriers faced by women in gaining access to scientific careers and decision-making bodies. The World Science Report 1996 is written by an international team of widely regarded authors. It is an essential source of facts, figures and discussion information for all those who want to know how present-day science is organized and how it functions.
Low-power digital processor for wireless sensor networks (2005)

In order to make sensor networks cost-effective and practical, the electronic compo-nents of a wireless sensor node need to run for months to years on the same battery. This thesis explores the design of a low-power digital processor for these sensor nodes, employing techniques such as hardwired algorithms, lowered supply voltages, clock gating and subsystem shutdown. Prototypes were built on both a FPGA and ASIC platform, in order to verify functionality and characterize power consumption. The resulting 0.18pm silicon fabricated in National Semiconductor Corporation&amp;apos;s process was operational for supply voltages ranging from 0.5V to 1.8V. At the lowest operat-ing voltage of 0.5V and a frequency of 100KHz, the chip performs 8 full-accuracy FFT computations per second and draws 1.2nJ of total energy per cycle. Although this energy/cycle metric does not surpass existing low-energy processors demonstrated in literature or commercial products, several low-power techniques are suggested that could drastically improve the energy metrics of a future implementation.
Doped electron localization: Electron paramagnetic resonance probing of La0.3Ca0.7MnO3 compound (2011)

The X-band electron paramagnetic resonance (EPR) was studied in the electron-doped ceramic La0.3Ca0.7MnO3. The model fittings of measured temperature dependences of the EPR linewidth and intensity were employed to probe the paramagnetic spin correlations and spin dynamics. These fittings revealed notable ferromagnetic short-range correlations and pure ion–ion spin relaxation in the paramagnetic state of La0.3Ca0.7MnO3. The latter fact supports the local nature of ferromagnetic double exchange coupling in this very case. It is suggested that such character of ferromagnetic exchange interactions results in the localization of carriers and establishing of charge ordered antiferromagnetic insulating ground state. This finding may be considered a strong prerequisite for the electron–hole doping asymmetry observed in the phase diagram of La–Ca manganites.
Minimum length of a single-mode fiber spatial filter (2002)

Using the concept of leaky modes, we derive the minimum length of a single-mode fiber required to act as a spatial-mode filter of given quality. The degree of filter action is defined by the ratio of power carried by the fundamental mode to that carried by the leaky modes.
Patent Citation Indexing and the Notions of Novelty, Similarity, and Relevance. (1966)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPatent Citation Indexing and the Notions of Novelty, Similarity, and Relevance.Eugene. GarfieldCite this: J. Chem. Doc. 1966, 6, 2, 63–65Publication Date (Print):May 1, 1966Publication History Published online1 May 2002Published inissue 1 May 1966https://pubs.acs.org/doi/10.1021/c160021a001https://doi.org/10.1021/c160021a001research-articleACS PublicationsRequest reuse permissionsArticle Views217Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Supplementary Table S1 from Tenascin-C Protects Cancer Stem–like Cells from Immune Surveillance by Arresting T-cell Activation (2023)

&lt;p&gt;Supplementary Table S1. Proteins identified and quantified in the SILAC experiment, comparing T cells inhibited by TPIN-SCs (CD62Lhi) with those activated by TNE-SCs (CD62Llo) or with the subset activated by TPIN-SCs (CD62Llo).&lt;/p&gt;
Kernresonanzspektroskopische beiträge zur struktur und stereochemie von (cyclo)aliphatischen isocyanaten und deren folgeprodukten (1986)

Abstract Es wird über 1 H‐NMR‐Untersuchungen an Isophorondiamin (IPDA) und Isophorondiisocyanat (IPDI) sowie ausgewählter Folgeprodukte berichtet. Dem jeweiligen Hauptisomeren wurde zweifelsfrei die trans‐Konfiguration zugeordnet. Ebenso werden die 13 C‐NMR‐Daten für eine Vielzahl von Folgeprodukten des n‐Butylisocyanats mitgeteilt. Mit Hilfe dieser Daten ist es nunmehr möglich, Abkömmlinge (cyclo)aliphatischer Isocyanate sicher zu charakterisieren. Das Datenmaterial ist auch in Hinblick auf die Analytik von Oligo‐ und Polymeren von Interesse.
Fecal chromogranins and secretogranins are increased in patients with ulcerative colitis but are not associated with disease activity (2013)

Fecal chromogranins and secretogranins are increased in UC but are not associated with disease activity, but seem to increase with duration of the disease. Thus, fecal granins might reflect structural changes associated with chronicity of disease, or medical therapy.
Haemoglobin distribution in ulcers for healing assessment (2012)

Wounds that do not follow a predictable course of healing within a specified period of time develop into ulcers causing severe pain and discomfort to the patients. One of the most prominent changes during wound healing is the colour of the tissues. Describing the tissues in terms of percentages of each tissue colour is an approved clinical method of wound healing assessment. The growth of the red granulation tissue marks the beginning of ulcer healing. Granulation tissue appears red in colour due to haemoglobin content in the blood capillaries. An approach based on utilizing haemoglobin content in chronic ulcers as an image marker to detect the growth of granulation tissue is investigated in this study. Independent Component Analysis is employed to extract grey-level haemoglobin images from RGB colour images of chronic ulcers. Extracted haemoglobin images indicate areas of haemoglobin distribution reflecting detected regions of granulation tissue. Data clustering techniques are implemented to classify and segment detected regions of granulation tissue from the extracted haemoglobin images. Results obtained indicate that the developed algorithm performs fairly well with an average sensitivity of 88.24% and specificity of 98.82% when compared to the dermatologist's assessment. The ultimate aim of this research work is to develop an objective non-invasive wound healing assessment system capable of evaluating the healing status of chronic ulcers in a more precise and reliable way.
62.1: Mechanical Reliability of LCD Panels under Static Loading (2004)

Abstract Previous studies of LCD glass strength have demonstrated that it is independent of glass thickness. Instead, it depends primarily on surface defects introduced in the glass during handling, processing and assembling of the LCD panel. This paper focuses on mechanical reliability of such a panel when mounted in the LCD module and subjected to static loading.
Activated Carbons for the Adsorption of Vapours from Cigarette Smoke (2010)

The main requirements for the adsorption of cigarette smoke vapours using active carbons and the methods currently being used to characterise and select carbons for this application are reviewed. Emphasis is placed on the total volume of smoke, the pulsed characteristics and relatively short challenge times, the compounds in the smoke and the environment in which adsorption takes place. Using experimental data, the types of carbons most suitable for cigarette filter application are considered, as are the adsorption kinetics required to meet this challenge. The concept of carbon ageing and the effects of water within the smoke are also reviewed.
Erbium Hydroxide Ethanedisulfonate: A Cationic Layered Material with Organic Anion Exchange Capability (2015)

We describe a cationic erbium-based material [Er12(OH)29(H2O)5][O3SCH2CH2SO3]3.5·5H2O. As synthesized, the material is water stable and capable of complete organic anion exchange for a variety of α,ω-alkanedicarboxylates. We chose these anions as initial examples of exchange and as an analog for pharmaceutical waste, some of which have a carboxylate functionality at neutral pH range. Free-floating and partially anchored organosulfonate anions reside between the cationic corrugated layers and allow for exchange. The structure also displays a reversible hydration event above 100 °C. Both the as-synthesized and the exchanged materials are characterized by a variety of analytical techniques.
Tantalum-based Compounds Prepared by Reactive Sputtering as a New Non-platinum Cathode for PEFC (2009)

Abstract Tantalum-based compounds prepared by reactive sputtering with heating were evaluated as novel non-platinum cathodes for polymer electrolyte fuel cells. Effects of species of target, TaC and TaN, and the oxygen partial pressure on catalytic activity for the oxygen reduction reaction (ORR) were investigated. We found that TaC target was more useful than TaN to prepare specimens with high ORR activity. In addition, the existence of an appropriate amount of O2 was needed with the TaC target to obtain superior catalytic activity for the ORR. XRD and TOF-SIMS analysis suggested that crystalline structure of TaON (monoclinic) and carbon on the surface might affect the catalytic activity for the ORR.
Polarized Th2 like cells, in the absence of Th0 cells, are responsible for lymphocyte produced IL-4 in high IgE-producer schistosomiasis patients (2002)

High IgE phenotype human schistosomiasis patients exhibit a coordinate regulation of IL-4 and IL-5 producing cells and the lymphocyte derived IL-4 comes from true polarized Th2 like cells, in the absence of measurable Th0 cells as measured by co-production of IL-4 and IFN-gamma.
Interactive In-Vitro Training In Physics Of Radiofrequency Ablation For Physicians And Medical Engineering Students. (2016)

Radiofrequency (RF) ablation requires a complex set of devices as well as profound electrophysiological experience and substantial knowledge of physical science basics. To establish RF ablation in-vitro teaching-system, six workstations were equipped with computer-controlled RF ablation generators. Universal connection boxes allow ablation-essays with catheters of different make and model. Special wetlabs were developed combining a basin containing isotonic saline solution with a thermostat and a pump to simulate blood flow. This hands-on teaching system can be used to demonstrate differences in lesion-forming dependent on tip-electrodes, sensor technology and ablation techniques, influence of blood flow and electrode-angle to the myocardium. It was also utilized to reproduce industrial in-vitro tests.
ChemInform Abstract: 3(2H)‐ISOCHINOLONE 1. MITT. IN 3‐STELLUNG O‐SUBSTITUIERTE ANALOGA DES PAPAVERINS ALS PERIPHER ANGREIFENDE VASODILATATOREN (1973)

Abstract Aus der Phenylessigsäure (I) erhält man mit Ammonacetat das zwischen (II) und (III) isomer zu formulierende Isochinolon, dessen Alkylierung am Stickstoff und am Sauerstoff gleichzeitig erfolgt und die N‐ und O‐Alkylverbindungen (IV) und (V) ergibt.