gebhart/patrepeval huggingface dataset:
Abstract 2769: DSRCT: Establishing xenograft and tissue culture cell lines and assessing chemosensitivity. (2013)

Abstract Desmoplastic small round cell tumor (DSRCT) is an extremely rare and aggressive neoplasm which mainly affects young males and generally presents as a widely disseminated tumor within the peritoneal cavity. Due to the rarity of the tumor, a younger and overall healthier patient population, and because it lacks definitive histologic and immunohistologic features, it is possible that DSRCT is frequently delayed in diagnosis or is entirely misdiagnosed as a different kind of abdominal sarcoma. This study seeks to rectify the dearth of models that exist for this rare neoplasm through the development of several DSRCT tissue culture and xenograft lines. Samples were received from surgeries and biopsies from patients around the world and were immediately processed for xenograft development in nude mice. Tumor tissues were minced and fragments were injected onto the dorsal flank of nude mice. Of the 15 samples received, 9 were established into xenograft lines and 6 of those into tissue culture lines. Xenografts displayed the microscopic histology of their parent tumors and two different growth rates among established xenograft lines. Chemosensitivity of tumors was assessed against a variety of chemotherapeutic agents and IC50 values established for each drug and cell line. Interestingly, the cell lines were split into two distinct groups in terms of morphology, growth rate and chemosensitivity. Overall, the establishment of these xenograft and tissue culture lines gives researchers tools to evaluate DSRCT response to chemotherapy and investigate DSRCT-specific signaling pathways or mechanisms. Citation Format: Constantine SA Markides, Dana M. Vardeman, Linh Luong, Douglas R. Coil, Anthony Kozielski, John Mendoza, Beppino C. Giovanella. DSRCT: Establishing xenograft and tissue culture cell lines and assessing chemosensitivity. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2769. doi:10.1158/1538-7445.AM2013-2769
Capacity analysis and comparison for cellular systems over different frequency bands (2016)

Operating frequency bands of the third generation (3G) cellular system and the long-term evolution (LTE) are usually below 3GHz. However, due to the limitation on bandwidth available below 3GHz, the throughput or capacity of 3G and LTE systems cannot be increased easily. This research investigated the feasibility of the application of a wider spectrum in the higher frequency band, such as 6–15GHz band to provide higher capacity for future mobile access. We studied the cumulative distribution of user throughput in cellular communication systems over different frequency bands. In order to evaluate the cellular capacity over different frequency bands, we set up a general cellular simulation model with configurable parameters such as cellular size, user density and frequency reuse factor. We analyzed the capacity of higher frequency communication according to the WINNER II model. The simulation results show that for given transmission environments, higher frequency bands can achieve better system capacity performance.
Supplementary Figure Legend and Methods from The Iron Chelator Dp44mT Causes DNA Damage and Selective Inhibition of Topoisomerase IIα in Breast Cancer Cells (2023)

Supplementary Figure Legend and Methods from The Iron Chelator Dp44mT Causes DNA Damage and Selective Inhibition of Topoisomerase IIα in Breast Cancer Cells
Cerebral and Systemic Stress Parameters in Correlation with Jugulo-Arterial CO2 Gap as a Marker of Cerebral Perfusion during Carotid Endarterectomy (2021)

Intraoperative stress is common to patients undergoing carotid endarterectomy (CEA); thus, impaired oxygen and metabolic balance may appear. In this study, we aimed to identify new markers of intraoperative cerebral ischemia, with predictive value on postoperative complications during CEA, performed in regional anesthesia. A total of 54 patients with significant carotid stenosis were recruited and submitted to CEA. Jugular and arterial blood samples were taken four times during operation, to measure the jugulo-arterial carbon dioxide partial pressure difference (P(j-a)CO<sub>2</sub>), and cortisol, S100B, L-arginine, and lactate levels. A positive correlation was found between preoperative cortisol levels and all S100B concentrations. In addition, they are positively correlated with P(j-a)CO<sub>2</sub> values. Conversely, postoperative cortisol inversely correlates with P(j-a)CO<sub>2</sub> and postoperative S100B values. A negative correlation was observed between maximum systolic and pulse pressures and P(j-a)CO<sub>2</sub> after carotid clamp and before the release of clamp. Our data suggest that preoperative cortisol, S100B, L-arginine reflect patients' frailty, while these parameters postoperatively are influenced by intraoperative stress and injury. As a novelty, P(j-a)CO<sub>2</sub> might be an emerging indicator of cerebral blood flow during CEA.
What's in a disease name? (2014)

An anniversary always provides some opportunity for reflection on what has been done so far and how it could be done better in the future. Naming is at the core of our daily practice. Looking at the hundreds of studies published by the BJD over the past 125 years, it is clear that naming is also central to much of what we write about the diseases we diagnose and treat. Giving a name to their ailment is what our patients expect from us; this is also what we are aiming at because diagnosis is key to proper treatment design. At first, it may seem that there is nothing more trivial than naming things, people or… diseases… After all, this is something we all do on a daily basis from an early age. However, naming can be a complex process, and occasionally the source of much confusion. The terms ‘mouse’ or ‘mailbox’ are nowadays used more often to designate electronic and quasi‐virtual entities rather than a small mammal or a familiar reddish box ornamenting the entrance to our houses. Words very often carry much more than their primary meaning. In fact, the more they carry, the more confusing they can be. And what is true of daily words is, of course, also true of disease names, which is why the more we know about a disease, its clinical spectrum of manifestations or its pathogenesis, the more difficult it is to give it a single, unequivocal and clinically useful name. And as diagnosis is all about giving a name to a constellation of clinical features, novel and quite dramatic advances in our understanding of the biological basis of diseases are paradoxically threatening the very foundations of the diagnostic process.
The Solvent Extraction of Palladium(II) from Hydrochloric Acid with Triisobutylphosphine Sulfide (1986)

Abstract The equilibrium and kinetic aspects of palladium(II) extraction from hydrochloric acid with triisobutylphosphine sulfide (TIBPS) in toluene were studied, along with the aqueous solubility and interfacial adsorption equilibrium of the extractant. From the equilibrium study, palladium(II) was found to be extracted as a 1:1 Pd:extractant binuclear complex. The extraction rate of palladium(II) was reasonably explained by the interfacial reaction model, assuming that the elementary reactions between the extractant adsorbed at the interface and the aquatrichloro and tetrachloro complexes of palladium(II), [PdCl3]−, and [PdCl4]2− in the aqueous phase are the rate-determining steps.
Planning and Managing the IPTV Service Deployment (2007)

The deployment of converged services of TV, telephony, and Internet access over IP entails a significant initial investment for service providers. This investment is not only for the underlying network infrastructure but also for provisioning and managing vast data centers needed to provide sophisticated IP-based TV (IPTV) experience, including multiple camera views, live (broadcast) and on demand programming, etc., to a large number of viewers. Thus the service providers need to carefully plan and manage the IPTV service deployment to maximize the return-on-investment while providing a good quality of experience to the subscribers. In this paper, we develop a methodology to aid service providers to effectively plan for the staggered deployment of IPTV services in this fledgling market. We present the utility of this framework by demonstrating a planning tool developed from this framework.
A New Synthetic Route for 3,4-Disubstituted Tetrahydrothiophenes and a New Fragmentation of Their Ring System (1986)

Desilylation of 2 -t r i m e t h y l s i l y l -3 , 4 -d 1 s u b s t 1 t u t e d tetrahydrothiophenes provided a n e w method for syntheszs of title compounds and a new fragmentation reaction of tetrahydroth~ophene ring.Thiocarbonyl ylides s t a b l l ~z e d by the trimethylsilyl substituent have been found to afford the 1,3-dipolar cycloadducts in excellent yields with conjugated 1 dipolarophiles .We wish t o descrlbe here a further conversion of these cycloadducts (1) into the corresponding tetrahydrothiophene derivatives ( 2 ) and a new fragmentation i n their desilylation.As shown i n Table 1 , treatment of 2 -t r i m e t h y l s i l y l t e t r a h y d r o t h i o p h e e e s (1) wlth c e s l u m fluoride i n hexamethylphosphoramide (HMPA) containing a little water or i n acetonltrlle gave the corresponding desilylated tetrahydrothiophene derlvatlves(2)'.A typical experiment i s described below.Cesium fluoride (152 mg, 1 mmol) was added to a solution of 2-trimethylsilyltetra h y d r o t h i o p h e n e -3 . 4 -( N -p h e n y 1 ) d i c ~r b o x y i m d(5) (305 mg, 1 mmol) i n HMPA (4 ml) containing a drop of water.After stirring for 3 h with heating at 80°C, the mixture was diluted with benzene, washed wlth water and saturated aqueous sodium chloride, and dried over MgSO,+, and concentrated under reduced pressure.A .B a r c o , S .B e n e t t z .F .M o r o d e r , 6 .P .P o l l l n i .D. S i m o n i , a
Focal plane charge detector for use in mass spectrometry (1992)

Since the advent of the microchannel plate (MCP) electron multiplier, the design of photon, electron and ion focal plane detectors (FPDs) has been an active but specialized research area. Recent rapid advances in support of integrated circuit design have brought powerful high-technology tools into the reach of research groups requiring custom FPDs. Focal plane detectors with an MCP front end are used in mass spectrometry, ultraviolet spectrophotometry, electron energy loss spectroscopy, etc., and are outlined. The design of a working charge detector on silicon is described and the proposed design of a new high-resolution FPD based on this detector is presented, with an explanation of the trade-offs made between the many design variables.
The robotics bus: a local communications bus for robots. (2002)

We address the development of a local bus architecture for robot systems that facilitates modular development, and increases the reliability of systems composed of heterogeneous sensors and actuators. The communications bus is based on Control Area Network (CAN), and supports distributed processing in physically separate nodes. Modular cabling and a modular software interface facilitate assembly and modification, and all bus communication is browseable for configuration and troubleshooting. We demonstrate two implementations of this system, and discuss its performance and capabilities compared to alternate communication architectures, with specific emphasis on mobile robots.
Electrooptic Bistability of a Ferroelectric Liquid Crystal Device Prepared Using Polyimide Langmuir-Blodgett Orientation Films (1988)

Excellent bistability was demonstrated in a ferroelectric liquid crystal electrooptic device prepared using polyimide Langmuir-Blodgett films for the orientation of the liquid crystals without performing rubbing.
Abstract 2324: Phospho-MED1 mediates the transcriptional regulation of AR splice variants in castration-resistant prostate cancer (2014)

Abstract The appearance of constitutively active androgen receptor splice variants (AR-Vs) has been proposed as one of the causes of castration-resistant prostate cancer (CRPC). Prior to treatment with enzalutamide or abiraterone, around 20-30% of CRPC patients already have high levels of AR-Vs in their metastases, especially ARv567es, and this portends a rapid progression and shorter survival. However, the underlying mechanism of AR-Vs in CRPC transcriptional regulation still remains unclear. A distinct transcriptome enriched with cell cycle genes (like UBE2C) has been associated with AR-Vs, which indicates the possibility of a different transcriptional mechanism than that of wild type AR. In our study, we performed co-immunoprecipitation, ChIP and luciferase reporter assays to explore the components involved in ARv567es activated UBE2C transcription. We found that (i) MED1 is necessary for ARv567es induced UBE2C up-regulation and subsequent prostate cancer cell growth; (ii) p-MED1 is recruited to ARv567es independent of full-length AR; (iii) p-MED1 has higher recruitment to UBE2C promoter and enhancer regions in the presence of ARv567es, (iv) ARv567es enhanced UBE2C transcription could be blocked by silencing MED1; (v) ARv567es/p-MED1 signaling cross talks with the PI3K-AKT pathway but not the MAPK pathway, and (vi) FoxA1 and histone methylation are involved in ARv567es/p-MED1 induced UBE2C long range chromatin interactions. In summary, these data indicate that p-MED1 serves as a key mediator in ARv567es transcriptional regulation and suggests a mechanism by which AR-Vs promote the development and progression of CRPC. Citation Format: Gang Liu, Cynthia Sprenger, Pin-Jou Wu, Shihua Sun, Takuma Uo, Kathleen Haugk, Kathryn Soriano Epilepsia, Stephen Plymate. Phospho-MED1 mediates the transcriptional regulation of AR splice variants in castration-resistant prostate cancer. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2324. doi:10.1158/1538-7445.AM2014-2324
Peroxisome Proliferators Activated Receptor-γ Agonists: Pioglitazone and Telmisartan; potential therapeutic approaches to the Metabolic Syndrome (2012)

At the crossroads of obesity, insulin resistance, and cardiovascular disease, is the nuclear receptor PPAR-γ. The modulation of PPAR-gamma activity is an interesting therapeutic approach to address multi-component metabolic syndrome. Any therapy that targets all the components of the metabolic syndrome is either non-existent or ineffective. Pioglitazone, a glitazone and Telmisartan, an angiotensin receptor blocker, share the unique property of activating PPAR-γ. Both have the potential to treat the hemodynamic, biochemical and inflammatory components of metabolic syndrome. To evaluate the efficacy of two PPAR-γ agonists; Pioglitazone and Telmisartan in treating multiple components of metabolic syndrome. This parallel group, interventional, randomized, open-labeled, active controlled comparative study, in patients having 3/5 NCEP-ATP III criteria was conducted at a University hospital. Changes in various hemodynamic and biochemical parameters along with hs-CRP, TNF-a, IL-6, at baseline and at 24 weeks, in the control group (n=20), Pioglitazone group (n=30) 30mg/day & Telmisartan group (n=30) 40mg/day, were studied. Analysis was done with Graph Pad Prism 5.0, two tailed p of <0.05 was considered significant (95% C.I). No statistically significant differences between the groups in various parameters were observed at baseline. Elevated waist circumference (WC), hypertension and diabetes mellitus were the most prevalent combination. Both Pioglitazone and Telmisartan were equally effective in reducing the WC, diastolic blood pressure and triglyceride. Pioglitazone was more effective in correcting hyperglycaemia, and Systolic Blood Pressure was more significantly reduced by Telmisartan. CRP and IL-6 were significantly and TNF-α was insignificantly reduced by telmisartan, vis-a-vis Pioglitazone. The present study provides the evidence of an anti-inflammatory and anti-atherogenic effect of PPAR-γ agonists: Pioglitazone and Telmisartan. The targeted treatment by PPAR-γ agonists is an effective monotherapy option in metabolic syndrome.
Estimating the Selectivity of Spatial Queries Using the 'Correlation' Fractal Dimension (2018)

We examine the estimation of selectivities for range and spatial join queries in real spatial databases. As we have shown earlier [FK94], real point sets: (a) violate consistentlythe "uniformity" and "independence" assumptions, (b) can often be described as "fractals", with non-integer (fractal) dimension. In this paper we show that, among the infinite family of fractal dimensions, the so called "Correlation Dimension" D2 is the one that we need to predict the selectivity of spatial join. The main contribution is that, for all the real and synthetic point-sets we tried, the average number of neighbors for a given point of the point-set follows a power law, with D2 as the exponent. This immediately solves the selectivity estimation for spatial joins, as well as for "biased" range queries (i.e., queries whose centers prefer areas of high point density). We present the formulas to estimate the selectivity for the biased queries, including an integration constant (Kshape!,) for each query shape. Finally, we show results on real and synthetic point sets, where our formulas achieve very low relative errors (typically about 10%, versus 40%-100% of the uniformity assumption).
Protection Genes in Nucleus Accumbens Shell Affect Vulnerability to Nicotine Self-Administration across Isogenic Strains of Adolescent Rat (2014)

Classical genetic studies show the heritability of cigarette smoking is 0.4-0.6, and that multiple genes confer susceptibility and resistance to smoking. Despite recent advances in identifying genes associated with smoking behaviors, the major source of this heritability and its impact on susceptibility and resistance are largely unknown. Operant self-administration (SA) of intravenous nicotine is an established model for smoking behavior. We recently confirmed that genetic factors exert strong control over nicotine intake in isogenic rat strains. Because the processing of afferent dopaminergic signals by nucleus accumbens shell (AcbS) is critical for acquisition and maintenance of motivated behaviors reinforced by nicotine, we hypothesized that differential basal gene expression in AcbS accounts for much of the strain-to-strain variation in nicotine SA. We therefore sequenced the transcriptome of AcbS samples obtained by laser capture microdissection from 10 isogenic adolescent rat strains and compared all RNA transcript levels with behavior. Weighted gene co-expression network analysis, a systems biology method, found 12 modules (i.e., unique sets of genes that covary across all samples) that correlated (p<0.05) with amount of self-administered nicotine; 9 of 12 correlated negatively, implying a protective role. PCR confirmed selected genes from these modules. Chilibot, a literature mining tool, identified 15 genes within 1 module that were nominally associated with cigarette smoking, thereby providing strong support for the analytical approach. This is the first report demonstrating that nicotine intake by adolescent rodents is associated with the expression of specific genes in AcbS of the mesolimbic system, which controls motivated behaviors. These findings provide new insights into genetic mechanisms that predispose or protect against tobacco addiction.
A Pictorial Tracking of Basal Plane Dislocations in SiC Epitaxy (2010)

The recently developed technique of UVPL imaging has been used to track the path of basal plane dislocations (BPDs) in SiC epitaxial layers. The glide of BPDs during epitaxial growth has been observed and the role of this glide in forming half-loop arrays has been examined. The ability to track the path of BPDs through the epitaxy has made it possible to develop a BPD reduction process for epitaxy grown on 8° offcut wafers, which uses an in situ growth interrupt and has achieved a BPD reduction of &gt; 98%. The images also provide insight into the strong BPD reduction that typically occurs in epitaxy grown on 4° offcut wafers.
Weight Gain and Progression to Type 2 Diabetes in Women With a History of Gestational Diabetes Mellitus (2015)

Postpartum increase in BMI is significantly associated with a risk of diabetes and deterioration of metabolic phenotypes in Korean GDM women.
Fast time domain simulation in SPICE with frequency domain data (2002)

The capability of time domain simulation with frequency domain data exists in some time-domain simulators, but the computations can be time-consuming. We decrease this computational burden by exploiting S-parameter fitter and fast recursive convolution methods. With recursive convolution the frequencies at which the S-parameters are sampled may be spaced in any way. For example, a logarithmic frequency spacing allows S-parameters to be sampled over a broader band without increasing the number of frequencies measured. We use two different system identification techniques for extracting the closed-form equations describing measured or simulated S-parameter data. Lumped parameter systems are approximated as a rational polynomial modulated by a complex exponential. Distributed parameter systems are approximated by the sum of complex exponentials. The recursive convolution engine handles both forms. The HP SPICE circuit simulator has been extended to allow fast, recursive convolution methods to be employed for transient analysis. The resulting simulator is called SSpice v2. Significant speed-up in the simulation of several circuits have been achieved using this new technique compared to both the traditional approach in SPICE and our previous direct-convolution-based approach in SSpice v1. In this paper, we present the algorithms and applications of the simulator. Three applications are demonstrated in the paper which are MR head flex line modeling, chip-to-chip signal modeling on MCM, and on-chip inductor modeling.
LEGACY01: STUDY DESIGN v1 (2023)

This protocol details the study design in an experimental medicine study of seasonal influenza vaccination responses in Lymph nodE single-cell Genomics in AnCestrY (LEGACY01).
Correlations of peritoneal interleukin‐6, serum beta‐2 microglobulin and urinary beta‐2 microglobulin after elective abdominal surgery (1993)

Postoperative peritoneal interleukin-6 (P-IL-6), serum beta-2 microglobulin (SBMG) and urinary beta-2 microglobulin (UBMG) concentrations were examined in 33 patients who underwent various types of abdominal surgery. Similar time-dependent changes in SBMG and UBMG were observed in five other patients who underwent abdominal surgery. SBMG decreased the first day after the operation (1POD), then increased and reached the preoperative level by the third day after the operation (3POD). UBMG started to increase 1POD, reached the maximum 3POD, then decreased. The 1POD SBMG concentration was significantly correlated with P-IL-6, and 3POD UBMG was also significantly correlated with P-IL-6. These findings indicate that serum and urinary beta-2 microglobulin concentrations are closely correlated with P-IL-6.
Review of the Fröhlich sliding mode in NbSe3 (1982)

The anomalous transport properties of the charge-density-wave system niobium triselenide are surveyed. Early experiments on the frequency dependence and non-ohmicity of the electrical conductivity are described together with interpretations using the sliding mode mechanism. The effect of impurities, the non-ohmic Hall effect, conduction noise, and ac conduction are described. Theoretical models which have been proposed arc discussed, together with difficulties from the experimental viewpoint. Lastly, mention is made of recent experiments on NbSe 3 as well as other similar systems.