gebhart/patrepeval huggingface dataset:
Symptom Index (SI) Is a Good Predictor of Success for Fundoplication for Symptomatic Non-Acid Reflux on PPI Therapy (2008)

Purpose: AIM: To compare SI versus SAP in a group of post-fundoplication patients with a positive SI resistant to PPIs. Methods: METHODS: A review of adult post-fundoplication patients who underwent follow up of symptoms improvement were identified. MII-pH studies were reviewed for each patient. SI was reviewed and SAP was calculated. Positive SI defined as >50% (i.e. at least half of the symptoms associated with reflux). SAP was calculated using the Sandhill Scientific Software with values >95% considered positive. Results: RESULTS: 29 (21 females, mean age 49, (range 23–78) years) adult post-fundoplication patients were identified. 24 (83%) patients reported being better or markedly improved over a mean follow-up of 16.5 months (range 5–28 months). Of the 24 patients, 22 (92%) had a positive SI and 6 (25%) had both a positive SI and SAP. Of the 5 patients who did not improve, 1 (20%) had a positive SI and 1 (20%) had a positive SAP. Conclusion: CONCLUSION: These preliminary findings suggest that SI may be an accurate parameter in predicting patients whose reflux symptoms will respond to fundoplication. Surprisingly, there was frequent disagreement between the SI and SAP. Further outcome studies are needed.
Grating Lobe Suppression with Element Count Optimization in Planar Antenna Array (2015)

The novel approach of this paper describes the suppression of grating lobe level with the element count optimization in planar antenna array. Rectangular lattice (RL) and triangular lattice (TL) structures are chosen for determining the achievable array element patterns (EP) and further suppressing the grating lobe level. The element spacing and number of elements (10 × 20 array) are taken into account for particular lattice. Grating lobe peaks are observed for the 200-element planar array at maximum scan angle (θ) with the set frequency of 3 GHz. Further, it is found that 14°; bore sight elevation of rectangular lattice produces a transformed field of view, which permits a reduction in element count of 20.39% compared with 10° bore sight elevation. Finally, the typical values of elevation, element count and array size (25 cm2) are trained using artificial neural network (ANN) algorithm and element count is predicted after testing the network. The network shows a high success rate.
Bacterial biofilm within diseased pancreatic and biliary tracts (2005)

A wide range of different branches and groups of bacteria participate in the development of biofilms on the surfaces of foreign bodies, such as biliary stents, mixed gall stones, or calcific pancreatic ducts, but not on the surface of pure cholesterol gall stones. Occlusion of stents leads to progressive extinction of the biofilm and mummification of its components. Deposition of cholesterol or other substances within the biofilm matrix may be a novel mechanism of host defence against bacteria present in these biofilms.
Secure communication via an energy-harvesting untrusted relay in the presence of an eavesdropper (2017)

This article studies a secure communication of a simultaneous wireless information and power transfer system in which an energy-constrained untrusted relay, which harvests energy from the wireless signals, helps the communication between the source and destination and is able to decode the source’s confidential signal. Additionally, the source’s confidential signal is also overheard by a passive eavesdropper. To create positive secrecy capacity, a destination-assisted jamming signal that is completely cancelled at the destination is adopted. Moreover, the jamming signal is also exploited as an additional energy source. To evaluate the secrecy performance, analytical expressions for the secrecy outage probability (SOP) and the average secrecy capacity are derived. Moreover, a high-power approximation for the SOP is presented. The accuracy of the analytical results is verified by Monte Carlo simulations. Numerical results provide valuable insights into the effect of various system parameters, such as the energy-harvesting efficiency, secrecy rate threshold, power-splitting ratio, transmit powers, and locations of the relay and eavesdropper, on the secrecy performance.
Antitumor activity of mitomycin C-dextran conjugate against various murine tumors. (1981)

The antitumor activity of a high molecular weight pro-drug of mitomycin C(MMC), MMC-dextran conjugate (MMC-D), was examined against various murine tumors under different experimental conditions. A single intraperitoneal injection of MMC-D exhibited higher antitumor activity against intraperitoneally inoculated B16 melanoma, Ehrlich ascites carcinoma, and P388 leukemia than MMC, but lower activity against BDF1 mouse-transplanted L1210 leukemia. Intratumoral injection of MMC-D showed a superior effect on subcutaneously implanted B16 melanoma, while intravenous injection of MMC-D exhibited reduced activity against P388 and L1210 leukemia compared with MMC. Prior administration of MMC-D at 24 hr before tumor inoculation resulted in a significant increase of the life span of mice bearing L1210 leukemia, suggesting that it shows sustained pharmacological activity. These differences between the activities of MMC-D and MMC in various tumor systems are considered to reflect the improved biopharmaceutical properties of MMC-D resulting from the modification of MMC into a polymeric drug.
Linear Precoding Based on Sub-Channel Permutation in Post-Combining MIMO-HARQ Systems (2006)

A powerful HARQ-based linear precoding scheme is proposed to utilize the flexibility of post-combining HARQ strategy in MIMO communications systems. The scheme selects the appropriate symbols and transmit powers for each eigen-mode to acquire more performance gains. Simulation results show that the proposed scheme achieves about 5.5dB signal-to-noise ratio gains over original spatial multiplexing scheme at an average bit error rate of 10 -4 . Furthermore, the gap between the two schemes increases with the number of transmissions.
Long-range, Non-local Switching of Spin Textures in a Frustrated Antiferromagnet (2021)

Antiferromagnetic spintronics is an emerging area of quantum technologies that leverage the coupling between spin and orbital degrees of freedom in exotic materials. Spin-orbit interactions allow spin or angular momentum to be injected via electrical stimuli to manipulate the spin texture of a material, enabling the storage of information and energy. In general, the physical process is intrinsically local: spin is carried by an electrical current, imparted into the magnetic system, and the spin texture then rotates. The collective excitations of complex spin textures have rarely been utilized in this context, even though they can in principle transport spin over much longer distances, using much lower power. In this study, we show that spin information can be transported and stored non-locally in the material Fe$_x$NbS$_2$. We propose that collective modes leverage the strong magnetoelastic coupling in the system to achieve this, revealing a novel way to store spin information in complex magnetic systems
The Relationship between Diurnal Variations in Intraocular Pressure Measurements and Central Corneal Thickness and Corneal Hysteresis (2009)

Measured IOP and corneal characteristics covary during office hours. Changes in CCT and CH are associated with changes in GAT IOP and, less consistently, with DCT IOP. The data suggest that variations in corneal characteristics explain a small proportion of the change in IOP measurements made with the GAT during office hours.
Dosimetric verification of breathing adapted radiotherapy using polymer gel (2006)

In radiation therapy patient movement caused by respiration can be a major challenge to the ambition to deliver a high absorbed dose to the target volume while minimizing the dose to normal tissues. Large respiratory motion requires increased margins, which implies an increased risk of morbidity from late toxicity. It is therefore important to take respiratory motion into account when treating targets in the thorax region. The aim of this study was to investigate the feasibility of using a 3D gel dosimeter for dose verification of breathing adapted radiotherapy
Combined high-resolution active and passive imaging of ocean surface winds from aircraft (2002)

A unique complement of passive and active microwave imaging and sensing instruments for observing ocean surface emission and scattering signatures were integrated onto the NASA Wallops Flight Facility's Orion P-3B aircraft (N426NA) for the purpose of studying the signature of ocean surface winds. The complement included: (i) a four-band (X, K, Ka, and W) tri-polarimetric scanning radiometer (PSR) (ii) a C-band ocean surface scatterometer (CSCAT), (iii) a Ka-band conical-scanning; polarimetric radiometer (KASPR), (iv) a nadir-viewing Ka-band polarimetric radiometer, (KAPOL) (v) a 21- and 31-GHz zenith-viewing cloud and water vapor radiometer (CWVR), and (vi) a radar ocean wave spectrometer (ROWS). The above Ocean Winds Imaging (OWI) complement was flown during January-March, 1997 over the Labrador Sea. Conically-scanned brightness temperature and backscatter imagery were observed over open ocean for a variety of wind speeds and cloud conditions. Presented herein are the results of a preliminary intercomparison of data from several of the OWI instruments.
Characterization of the effects of metformin on porcine oocyte meiosis and on AMP-activated protein kinase activation in oocytes and cumulus cells (2013)

The adenosine monophosphate-activated protein kinase (AMPK) activators 5-aminoimidazole-4-carboxamide 1-β-d-ribofuranoside (AICAR) and metformin (MET) inhibit resumption of meiosis in porcine cumulus-enclosed oocytes. The objective of this study was to characterize the inhibitory effect of MET on porcine oocyte meiosis by: (1) determining the effects of an AMPK inhibitor and of inhibitors of signalling pathways involved in MET-induced AMPK activation in other cell types on MET-mediated meiotic arrest in porcine cumulus-enclosed oocytes; (2) determining whether MET and AICAR treatments lead to increased activation of porcine oocyte and/or cumulus cell AMPK as measured by phosphorylation of its substrate acetyl-CoA carboxylase; and (3) determining the effects of inhibition of the AMPK kinase, Ca2+/calmodulin-dependent protein kinase kinase (CaMKK), and Ca2+ chelation on oocyte meiotic maturation and AMPK activation in porcine oocytes and cumulus cells. The AMPK inhibitor compound C (CC; 1 μM) did not reverse the inhibitory effect of AICAR (1 mM) and MET (2 mM) on porcine oocyte meiosis. Additionally, CC had a significant inhibitory effect on its own. eNOS, c-Src and PI-3 kinase pathway inhibitors did not reverse the effect of metformin on porcine oocyte meiosis. The level of acetyl-CoA carboxylase (ACC) phosphorylation in oocytes and cumulus cells did not change in response to culture in the presence of MET, AICAR, CC, the CaMKK inhibitor STO-609 or the Ca2+ chelator BAPTA-AM for 3 h, but STO-609 increased the percentage of porcine cumulus-enclosed oocytes (CEO) that remained at the germinal vesicle (GV) stage after 24 h of culture. These results indicate that the inhibitory effect of MET and AICAR on porcine oocyte meiosis was probably not mediated through activation of AMPK.
Regulation of Biosynthesis, Release and Degradation of Insulin in Cultured Rat Islets1) (2009)

In order to study the long-term influence of glucose on islet cell functions, biosynthesis of (pro)insulin (3H-leucine incorporation during 3h-incubation both at 50 and 300 mg/dl of glucose), release of insulin and somatostatin and degradation of intra-insular insulin were measured in isolated rat islets, cultured for 3 days at 50, 150 and 300 mg/dl glucose. After culture at 50 mg/dl of glucose, (pro) insulin biosynthesis was very low during 3 h incubation in presence of either 50 or 300 mg/dl glucose; whereas, after culture at 300 mg/dl glucose, a sustained high rate of biosynthesis was observed. This priming-effect concerning hormone release during incubation period, in relation to the previous glucose concentration of culture medium was better proportional for D-cells than for the B-cells. During the 3 days of culture, the percentual differences in hormone release at 50, 150 and 300 mg/dl of glucose were, altogether, also higher for somatostatin than for insulin. Insulin degradation was strongly enhanced during culture at 50 mg/dl glucose (total insulin before culture: 526 +/- 57 microU/islet; after culture at 50, 150 and 300 mg/dl glucose (in islets plus media): 253 +/- 25, 975 +/- 90 and 1030 +/- 96 microU/islet, respectively). The glucose-priming of islet cells differed for the various cell functions. At low glucose concentration the pre-synthesized insulin (which was not needed then physiologically) was again degraded within the islet cells; at higher concentrations of glucose, increased stimulation of the B-cells seemed to be modified by the--paracrine--action of somatostatin.
Toward History-Aware Robust 802.11 Rate Adaptation (2012)

Rate adaptation is a mechanism unspecified by the IEEE 802.11 standards, yet critical to the system performance by exploiting the multirate capability at the physical layer. In this paper, we conduct a systematic experimental study on rate adaptation over 802.11 wireless networks. Our key contributions are as follows: First, we present a critique on popular design guidelines adopted by many practical algorithms and we uncover their limitations. Our study reveals that these seemingly correct guidelines can be misleading in practice, thus incurring significant performance penalty in certain scenarios. Second, we study the short-term channel dynamics and explore how they guide rate adaptation. To this end, we design and implement a new History-Aware Robust Rate Adaptation Algorithm (HA-RRAA). HA-RRAA uses short-term loss ratio to opportunistically guide its rate change decisions, a cost-effective adaptive RTS filter to prevent collision losses from triggering rate decrease and an adaptive time window to limit transmissions at high loss rates. Our extensive experiments show that HA-RRAA outperforms popular algorithms in all tested scenarios, with goodput gains up to 51.9 percent in field trials.
Manifestation of the Dilute Black (bd) Mutation and Constitution of the bd Locus in Bombyx mori (2007)

A Bombyx mori mutant named dilute black (bd), which has the multiple alleles bd, bd^{sw} and bd^f, each affecting both the larval body color and female fertility, was investigated for the manifestation of these pleiotropic traits by mating experiments with the k40, k42 and k452 strains harboring bd, bd^{sw} and bd^f, respectively, in the heterozygous state. It was shown that bd, bd^{sw} and bd^f were strong, intermediate and weak, respectively, in the degree of larval body color. On the other hand, bd and bd^{sw} were identical to each other in terms of female sterility, whereas bd^f was as fertile as normal. The degree of body color and the female sterility showed a high parallelism with each other. On the basis of these results, we proposed that the bd locus consists of closely linked two domains, one for the larval body color and the other for the female fertility.
Stark spectroscopy and Autler-Townes interactions in four-level cesium atoms (1987)

Scalar and tensor polarizabilities of cesium 5f and 7d states were measured by three-color multiphoton excitation techniques. The low-field results were quadratic and were in good agreement with calculated values. The oscillator strength for the 5f-5g transition was measured to be 0.0336\ifmmode\pm\else\textpm\fi{}0.0003, in close agreement with theory. At higher electric fields, we clearly resolved Autler-Townes avoided crossings between 5f levels and dressed 7d states. The observed doublet-component separations scaled linearly with Rabi frequency for the 7d-5f transitions, supporting a two-level model for the four-level experiment. The results are interesting because the observed spectra were independent of Rabi frequencies for the 6s-6p and 6p-7d transitions. Angular momentum forbidden transitions from 7d, ${J}_{z}$=(1/2) to 5f, ${J}_{z}$=(5/2) were observed at higher dc fields. These are attributed to dc-field-induced mixing between nearly degenerate 5f and 5g states.
Stem Cell Salvage of Injured Peripheral Nerve (2013)

We previously developed a collagen tube filled with autologous skin-derived stem cells (SDSCs) for bridging long rat sciatic nerve gaps. Here we present a case report describing a compassionate use of this graft for repairing the polyinjured motor and sensory nerves of the upper arms of a patient. Preclinical assessment was performed with collagen/SDSC implantation in rats after sectioning the sciatic nerve. For the patient, during the 3-year follow-up period, functional recovery of injured median and ulnar nerves was assessed by pinch gauge test and static two-point discrimination and touch test with monofilaments, along with electrophysiological and MRI examinations. Preclinical experiments in rats revealed rescue of sciatic nerve and no side effects of patient-derived SDSC transplantation (30 and 180 days of treatment). In the patient treatment, motor and sensory functions of the median nerve demonstrated ongoing recovery postimplantation during the follow-up period. The results indicate that the collagen/SDSC artificial nerve graft could be used for surgical repair of larger defects in major lesions of peripheral nerves, increasing patient quality of life by saving the upper arms from amputation.
Distributions of paced intramyocardial velocity as a predictor of sudden arrhythmic death (2002)

A new method has been developed for investigation of the potential for ventricular arrhythmias in the cardiomyopathies. It is based on the idea that myofibrillar disarray will cause dispersion of conduction and so create one component of a reentrant substrate. One ventricular site is paced with a decremental sequence and electrograms are recorded from three other RV sites. Fractionation of the recorded electrograms are measured by determining the distribution of transitions which presumably correspond to activation of discrete fibre bundles near the stimulating electrode. The rate at which electrogram duration and length increases with premature stimulation correlates strongly with the risk of ventricular arrhythmias.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Asymmetric Synthesis of Oxygen Heterocycles via Pd‐Catalyzed Dynamic Kinetic Asymmetric Transformations: Application to Nucleosides. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Impact of a homing intein on recombination frequency and organismal fitness (2016)

Inteins are parasitic genetic elements that excise themselves at the protein level by self-splicing, allowing the formation of functional, nondisrupted proteins. Many inteins contain a homing endonuclease (HEN) domain and rely on its activity for horizontal propagation. However, successful invasion of an entire population will make this activity redundant, and the HEN domain is expected to degenerate quickly under these conditions. Several theories have been proposed for the continued existence of the both active HEN and noninvaded alleles within a population. However, to date, these models were not directly tested experimentally. Using the natural cell fusion ability of the halophilic archaeon Haloferax volcanii we were able to examine this question in vivo, by mating polB intein-positive [insertion site c in the gene encoding DNA polymerase B (polB-c)] and intein-negative cells and examining the dispersal efficiency of this intein in a natural, polyploid population. Through competition between otherwise isogenic intein-positive and intein-negative strains we determined a surprisingly high fitness cost of over 7% for the polB-c intein. Our laboratory culture experiments and samples taken from Israel's Mediterranean coastline show that the polB-c inteins do not efficiently take over an inteinless population through mating, even under ideal conditions. The presence of the HEN/intein promoted recombination when intein-positive and intein-negative cells were mated. Increased recombination due to HEN activity contributes not only to intein dissemination but also to variation at the population level because recombination tracts during repair extend substantially from the homing site.
Spin Reversal of a Quantum Hall Ferromagnet at a Landau Level Crossing (2020)

When Landau levels (LLs) become degenerate near the Fermi energy in the quantum Hall regime, interaction effects can drastically modify the electronic ground state. We study the quantum Hall ferromagnet formed in a two-dimensional hole gas around the LL filling factor ν=1 in the vicinity of a LL crossing in the heave-hole valence band. Cavity spectroscopy in the strong-coupling regime allows us to optically extract the spin polarization of the two-dimensional hole gas. By analyzing this polarization as a function of hole density and magnetic field, we observe a spin flip of the ferromagnet. Furthermore, the depolarization away from ν=1 accelerates close to the LL crossing. This is indicative of an increase in the size of skyrmion excitations as the effective Zeeman energy vanishes at the LL crossing.
Molecular cloning of a novel isolate of feline immunodeficiency virus biologically and genetically different from the original U.S. isolate (1991)

The Japanese isolate (TM1 strain) of feline immunodeficiency virus (FIV) which replicates in a feline CD4 (fCD4)-positive lymphoblastoid cell line (MYA-1 cells) was molecularly cloned from extrachromosomal closed circular DNA. The restriction map of the clone, termed pFTM 191 complete genome (CG), showed a considerable difference from that of the U.S. isolate (Petaluma strain) of FIV. The sequence homology in the long terminal repeat between the TM1 and Petaluma strain was 82%. The pFTM 191 CG was biologically active after transfection into Crandell feline kidney cells which were permissive for replication of FIV Petaluma. However, the progeny virions could not reinfect fCD4-negative Crandell feline kidney cells but could infect fCD4-positive MYA-1 cells. When a specific-pathogen-free cat was inoculated with the virus derived from the pFTM 191 CG, the cat seroconverted within 8 weeks postinoculation and FIV was reisolated at 4, 8, and 20 weeks postinoculation. These results indicate the infectivity of the pFTM 191 CG in vivo.
Performance evaluation of congestion avoidance in broadband ISDNs (1990)

The authors present a performance evaluation of a simple yet effective technique for congestion avoidance in broadband integrated services digital networks (B-ISDNs). With this method, an incoming call is accepted only if its bandwidth requirement is not more than a predefined percentage of unused bandwidth at that moment. If this condition is not satisfied by an incoming call, it is blocked and cleared. This technique was simulated for a network that supports three services. The bandwidth requirements (in terms of cells per call) of these services are assumed to be geometrically distributed. Simulation results are presented in terms of call-blocking probabilities for several different cases.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>