gebhart/patrepeval huggingface dataset:
Genetics and biological markers of risk for alcoholism. (1988)

Substantial scientific evidence has accumulated that both genetic and environmental factors predispose the development of alcoholism in certain individuals. Evidence has accumulated to indicate that alcoholism is a heterogeneous entity arising from multiple etiologies. The demonstrated role of genetics in increasing the risk of alcoholism has promoted the search for biological markers that could objectively identify individuals who are genetically predisposed to alcoholism. Identifying such markers could allow for early diagnosis, focused prevention, and differential and type-specific treatment of alcoholism. Promising markers have been provided by research in electrophysiology, endocrinology, and biochemistry. Recent advances in molecular genetics are offering prospects for direct analysis of the human genome to determine elements that provide predisposition to, and protection from, alcoholism. Recent advances in research and new knowledge gained by the alcoholism treatment community and the lay public are helping to diminish the societal damage caused by alcohol abuse and alcoholism and to change prevailing attitudes about them.
The Protract and Application of Vector Graphics Based on Visual C (2011)

Electronic map is important component of GIS.In this article,we use Visual C++6.0 MFC read AutoCAD DXF datesheet,get text data directly by programme and store in database.We also draw vector graphics by MFC program and display in screen.We implement car auto drive with GPS system..
Online Approval Committee Elections (2022)

Assume $k$ candidates need to be selected. The candidates appear over time. Each time one appears, it must be immediately selected or rejected -- a decision that is made by a group of individuals through voting. Assume the voters use approval ballots, i.e., for each candidate they only specify whether they consider it acceptable or not. This setting can be seen as a voting variant of choosing $k$ secretaries. Our contribution is twofold. (1) We assess to what extent the committees that are computed online can proportionally represent the voters. (2) If a prior probability over candidate approvals is available, we show how to compute committees with maximal expected score.
Polydopamine‐Mediated Surface Functionalization of Exosomes (2021)

Abstract Exosomes are cell‐derived extracellular vesicles that hold promise for diagnosis and therapy. The surface characteristics of exosomes dictate their biological fate and are therefore important for various applications, however surface modification strategies are generally either limited in scope or require complex equipment or experimental procedures. Herein, we employ a simple and fast method to control the surface properties of exosomes via polydopamine coating. Specifically, the polydopamine coating allowed for tailorable functionalization via secondary reactions, which opens exciting avenues for the application of exosomes.
Fluoxetine Not Associated With Increased Violence or Aggression in Controlled Clinical Trials (1992)

AbstractBecause of interest in the possible occurrence of violent 01 aggressive behavior with serotonin-enhancing drugs, three subpools of controlled clinical trial data were evaluated: fluoxetine (n = 2615) versus placebo (n = 1377) (18 trials; depression, bulimia nervosa, obesity, alcoholism, smoking cessation); fluoxetine (n = 441) versus tricyclic antidepressants (n = 445) (ten trials; depression); and fluoxetine (n = 309) versus tricyclic antidepressants (n = 308) versus placebo (n = 297) (three trials; depression, including adjustment disorder). Adverse event terms possibly involving physically assaultive acts toward another (antisocial reaction, hostility, and personality disorder, together termed the “aggression cluster”) were reviewed. Across all indications, a statistically significantly smaller proportion of fluoxetine-treated patients than placebo-treated patients experienced one or more of the events (0.15% versus 0.65%, respectively). Placebo-treated patients were four times more likely to e...
ChemInform Abstract: Unexpected Synthesis of Halogenated Carboxylic Acids Containing a Thiocarbamate Group. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Taxonomy of Some Recently Described Species in the Family Enterobacteriaceae (1976)

The taxonomic positions of several recently described species, Levinea malonatica, Levinea amalonatica, Citrobacter diversus, and Enterobacter agglomerans, were investigated by numerical analysis. A set of 141 strains, for which a total of 240 characters was recorded, was analyzed and also compared with representatives of a set of 384 strains of bacteria, examined in an earlier study, representing genera within the family Enterobacteriaceae. Three clusters of Citrobacter spp. were observed, Citrobacter freundii, Citrobacter spp., and Levinea amalonatica, with strains received as Citrobacter diversus and Levinea malonatica clustering with the Citrobacter spp. Citrobacter intermedius was concluded to be synonymous with C. freundii. L. malonatica, from the results of this study, was included in the species C. diversus. Hydrogen sulfide-positive strains of Escherichia coli were not judged to warrant separate species status. Klebsiella aerogenes, Klebsiella pneumoniae, Klebsiella oxytoca, and Klebsiella edwardsii were found to be highly related (similarity values &gt; 90%). It is proposed that these species be merged into a single species, Klebsiella pneumoniae.
Hepatitis C Virus Core-Derived Peptides Inhibit Genotype 1b Viral Genome Replication via Interaction with DDX3X (2010)

The protein DDX3X is a DEAD-box RNA helicase that is essential for the hepatitis C virus (HCV) life cycle. The HCV core protein has been shown to bind to DDX3X both in vitro and in vivo. However, the specific interactions between these two proteins and the functional importance of these interactions for the HCV viral life cycle remain unclear. We show that amino acids 16-36 near the N-terminus of the HCV core protein interact specifically with DDX3X both in vitro and in vivo. Replication of HCV replicon NNeo/C-5B RNA (genotype 1b) is significantly suppressed in HuH-7-derived cells expressing green fluorescent protein (GFP) fusions to HCV core protein residues 16-36, but not by GFP fusions to core protein residues 16-35 or 16-34. Notably, the inhibition of HCV replication due to expression of the GFP fusion to HCV core protein residues 16-36 can be reversed by overexpression of DDX3X. These results suggest that the protein interface on DDX3X that binds the HCV core protein is important for replicon maintenance. However, infection of HuH-7 cells by HCV viruses of genotype 2a (JFH1) was not affected by expression of the GFP fusion protein. These results suggest that the role of DDX3X in HCV infection involves aspects of the viral life cycle that vary in importance between HCV genotypes.
Receiver techniques for reception of C-MAC DBS signals (1985)

Various possibilities for implementing receivers for DBS C-MAC signals are described, in particular for low carrier-to-noise ratio operation and improved interference rejection. Consideration is given to the choice of the second intermediate frequency and to both conventional and threshold extension phase-locked-loop demodulation for the vision signal. Differential demodulation of the 2–4PSK sound/data signal is considered, including the effects of i.f. and delay line time errors.
Draft Genome Sequence of the Arsenate-Respiring Bacterium Chrysiogenes arsenatis Strain DSM 11915 (2013)

Here we present the draft genome sequence of Chrysiogenes arsenatis strain DSM 11915, only the second genome sequence from the phylum Chrysiogenetes. This strictly anaerobic organism was isolated from arsenic-contaminated gold mine wastewater and respires arsenate or nitrate instead of oxygen. The assembly contains 2,824,977 bp in 22 scaffolds.
Lycorine Attenuates Airway Inflammation in an OVA induced Allergic Asthma Model (2023)

Abstract: Background: Asthma is one of the most prevalent, complex, and severe respiratory disorders, with rising rates of occurrence and death in both children and adults. An alkaloid derived from plants, lycorine possesses several pharmacological effects, primarily anti-inflammatory and antioxidative properties. Materials and Methods: In the current study, the anti-asthmatic potential of lycorine against ovalbumin (OVA)-induced asthma mice model has been examined. The animals were categorized into five groups. The group I mice received saline while the group II mice received OVA. Groups III mice were provided with OVA + Lycorine in low dose whereas group IV mice were given OVA + Lycorine in high dose. Group V animals received OVA + Dexamethasone, which was used as the positive control. The bronchoalveolar lavage fluid isolated from the lungs was utilized to estimate various parameters such as total and differential immune cells (eosinophils, neutrophils, lymphocytes, macrophages), secreted inflammatory cytokines levels, and oxidative stress markers. The lungs were subjected to histological examination and respiratory mechanics examination. Results: Lycorine treatment significantly suppressed the total and differential immune cells, IgE, IL-4, IL-5, IL-13, and TNF-α cytokines, MDA, NO2 and NO3 levels and enhanced the IFN-γ cytokine level along with the SOD, CAT, and GSH enzyme activities. Further, the histopathological study revealed that lycorine was able to decrease the thickness of the columnar epithelial cells in the airways. Thus, lycorine suppressed the ROS generation that in turn reduced the inflammation in the airways of the lungs by reducing Th2 cytokines and augmenting the levels of Th1 cells. Conclusion: These findings indicate that lycorine was able to regulate the Th1/Th2 balance OVA-challenged asthmatic mice, signifying its protective impact that may be valuable in the management of allergic asthma. Keywords: Asthma, Ovalbumin, Lycorine, Inflammatory cytokines, Oxidative stress.
DETERIORATION OF AGGREGATES - THE UNDERLYING CAUSES. CONCRETE DURABILITY. KAHTERINE AND BRYANT MATHER INTERNATIONAL CONFERENCE, HELD AT ATLANTA, GEORGIA, USA, 27 APRIL-MAY 1987 (1987)

Freezing and thawing cycles in northern latitudes have resulted in the break-down of some aggregates and concrete. De-icing salts have accelerated the problem. However, freezing of water cannot be the principal cause of deterioration, since in the fine grained aggregates and cement paste the pores are too small to allow freezing. Yet it is these materials that deteriorate the most. De-icing salts likewise lower the freezing point and the number of freeze-thaw cycles, yet cause increased breakdown. The same materials susceptible to freeze-thaw breakdown also deteriorate significantly under repeated wetting-drying cycles. Laboratory experiments show these materials to expand on wetting and contract on drying. Nacl solution causes significantly greater expansion. Ice formation in the pores, therefore, is not the primary cause of breakdown. The answer may be found in the nature of the water in the small pores -water affected by the capillary and surface forces of the pore material. The pore water has lower vapour pressure, which prevents it from freezing, but which results in osmotic pressure differential, causing expansion. De-icing salt cations are preferentially adsorbed and concentrated on pore surfaces, further increasing the osmotic potential, expansion, and breakdown. Methods that determine the pore size distribution, surface sorption characteristics of the pore walls, and volume changes on wetting are suggested as more definitive measures of aggregate (and concrete) durability, compared to some of the currently accepted tests. This paper presents an overview of processes causing the aggregate breakdown, based on the theoretical and laboratory-derived evidence accumulated in the author's laboratory over the last 15 years. (AuthoR/TRRL)
A netlist pruning tool for an electronic system prototyping platform (2013)

The increasing complexity of electronic systems makes the recognition of subcircuits in a main circuit a desirable feature to several Electronic Design Automation tools (EDA). This paper presents an efficient Netlist Pruning Tool (NPT) for an electronic system prototyping platform. The tool first parses any EDIF netlist and represents the circuit into a graph. Then a subgraph isomorphism algorithm is applied for detecting the subcircuits' patterns and, for each pattern detected, appropriate actions are triggered. NPT was successfully applied to several PCB netlists to prune typical pull-up/pull-down resistors and decoupling capacitors, such as a netlist with up to 51 233 components and 70354 nets with a run time of 101.32 s.
Ultra-fast Decentralized Self-Aligned Carrier Principle for Multiphase/Multilevel Converters (2020)

International audience
Structural Alignments of (+)- and (-)-trans-anti-Benzo[a]pyrene-dG Adducts Positioned at a DNA Replication Fork Junction (1995)

The structural features of a chemically modified DNA template strand may promote error-prone DNA synthesis during replication. The resulting higher incidence of mutations, in turn, can eventually lead to tumor initiation. Structural insights into this process can be monitored by studying chemically modified base adducts of defined stereochemistry positioned site-specifically at a single strand--duplex template--primer junction. We have used a NMR-molecular mechanics approach to obtain the solution conformations of the covalent adducts derived from trans additions at the [BP]C10 position of the highly tumorigenic (+)-anti-benzo[a]pyrene diol epoxide [(+)-anti-BPDE] and nontumorigenic (-)-anti-benzo-[a]pyrene diol epoxide [(-)-anti-BPDE] to the N2 position of guanine [(+) and (-)-trans-anti-[BP]dG, respectively] in the d(A1-A2-C3-[BP]G4-C5-T6-A7-C8-C9-A10-T11-C12-C13).d (G14-G15-A16-T17-G18-G19-T20-A 21-G22) 13/9-mer DNA sequence. The modified 13-mer strand constitutes the template strand, while the complementary 9-mer strand constitutes a primer which has been synthesized from the 3'-end of the template toward the 5'-end up to the base preceding, but not including, the modified guanine. The modified guanine (denoted by [BP]dG4) is positioned at the junction site between the single-stranded and duplex segments. Structural features of the (+)-trans-anti-[BP]dG 13/9-mer have been determined by incorporating proton--proton distances defined by lower and upper bounds deduced from NOESY spectra as restraints in molecular mechanics computations in torsion angle space. The 3'-side duplex segment retains a minimally perturbed B-DNA conformation with all nine base pairs in Watson--Crick hydrogen-bonded alignments. Conformational heterogeneity is detected at the single-stranded d(A1-A2-C3) segment located 5' to the modified (+)-trans-anti-[BP]dG lesion which contrasts with an unperturbed alignment of these same residues in the unmodified control 13/9-mer. The modified guanine adopts a syn glycosidic torsion angle, is displaced into the major groove, and no longer stacks over the adjacent dC5.dG22 base pair. Such a base displacement is accompanied by stacking of one face of the pyrenyl ring with the dC5.dG22 base pair located on the duplex segment proximate to the modified guanine, while the other face of BP is exposed to solvent.(ABSTRACT TRUNCATED AT 400 WORDS)
ExaGraph: Combinatorial Methods for Enabling Exascale Applications. (2019)

Abstract not provided.
Vitamin D, Pregnancy, Breastfeeding, and Postpartum Multiple Sclerosis Relapses (2010)

Pregnancy and exclusive breastfeeding are strongly associated with low 25(OH)D levels in women with MS. However, these lower vitamin D levels were not associated with an increased risk of postpartum MS relapses. These data suggest that low vitamin D in isolation is not an important risk factor for postpartum MS relapses.
Determination of the thermodynamic acidity constant of HPBI using the binding mean spherical approximation model. (1999)

International audience
Copper‐carbohydrate Interaction: Part II (1990)

In this second part of the review the roles that copper and dietary carbohydrate play in the cardiovascular system, pregnancy and lactation, haemopoiesis, and in male and female animals, are summarised. The mechanisms that may contribute to the exacerbation of copper deficiency when simple sugars are consumed are discussed.
P‐55: A Tacky Photopolymer for Dry Phosphor Screening of Emissive Displays (2005)

Abstract A dry phosphor screening process for emissive displays using DuPont's Tacky Dot® technology was developed and investigated. The photopolymer may be adhered to various substrates and patterned by polymerization through UV exposure. Then phosphor particles are loaded onto these patterns. The photopolymer's deposition, adhesion, and decomposition properties have been evaluated.
ChemInform Abstract: Facile One‐Pot Synthesis of Poly‐Substituted Phenols from Baylis—Hillman Adducts via [4 + 2] Annulation Protocol. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Deformation Resistance in Plate Rolling of Commercially Pure Titanium and Ti-6Al-4V Alloy (1986)

Hot deformation resistance of commercially pure (C.P.) titanium and Ti-6 Al-4 V alloy was investigated by uni-axial compression and plain strain compression tests. For both titanium plates, mill load and rolling temperatures during hot rolling in a wide plate mill were measured, and mean hot deformation resistance was calculated based on the rolling theory and heat transfer model. Reheating temperatures of C.P.Ti and Ti-6Al-4V alloy were 850°C and 950°C respectively, and the finish-rolling temperature of Ti-6Al-4V alloy was aimed to be reduced below 750°C. The true stress-true strain curve of C.P.Ti was that of dynamic recovery type, which was characterized by work hardening with straining, followed by steady state flow stress. On the other hand, the S-S curve of Ti-6Al-4V alloy exhibited high temperature yielding at a small strain, followed by softening and steady state flow behavior. The mean deformation resistance obtained by plain strain compression testing was higher by 1.5 to 3 times than that from uniaxial compression testing. Hot deformation resistance equations established by analysis of mill load and rolling temperature were well consistent to that from plain strain compression testing in which residual strain was taken into consideration. The residual strain in C.P.Ti and Ti-6Al-4V alloy started to take place at the rolling temperatures of 750°C and 850°C respectively, and hot deformation resistance in both titanium plates markedly increased below these temperatures due to strain accumulation.
COMO OTIMIZAR A ESTABILIZAÇÃO DOS EQUIPAMENTOS FOTOATIVADORES SOBRE RESTAURAÇÕES? (2021)

Após discutirmos como a distância entre os equipamentos fotoativadores e os materiais resinosos pode influenciar no resultado final de restaurações, vamos discutir como a estabilização dos equipamentos sobre os materiais restauradores também é fundamental para uma polimerização eficiente. Os materiais resinosos fotoativados precisam receber uma determinada quantidade de luz (exposição radiante) para que sejam polimerizados adequadamente. Quando movimentamos os equipamentos fotoativadores sobre a restauração, podemos deixar parte do material resinoso sem receber essa energia luminosa necessária ou interromper o processo de ativação, causando uma polimerização insuficiente (Fig. 1)1 . Sabe-se que a luz azul emitida pelos equipamentos fotoativadores é prejudicial aos olhos e pode causar uma degradação da visão em longo prazo2 . Frente à falta de barreiras de proteção contra luz azul, é comum desviar o olhar durante o processo de fotoativação.
Predicting surface figure in diamond turned calcium fluoride using in-process force measurement (2005)

Single crystal calcium fluoride (CaF2) shows significant variation in material properties as a function of crystallographic orientation. The surfaces generated by material removal processes such as diamond turning are influenced by this anisotropy and consequently show periodic undulations aligned with the crystal structure. This article explores the relationship between surface figure and cutting forces measured during the diamond turning of single crystal calcium fluoride. The cutting forces, when mapped to the physical geometry of CaF2 plano (flat) optics, show good correlation with surface figure measured by interferometry. A model is presented to predict the surface figure error from the experimentally measured normal component of the cutting force. The model also shows how the surface figure obtained under various machining parameters may be extrapolated from force measurements made during a single diamond turning operation.
Interface Trap Density Estimation in FinFETs Using the Method in the Subthreshold Regime (2016)

In this paper, we show that the subthreshold current-voltage characteristic can be used for estimating the interface trap density as a function of the energy in fully depleted symmetric metal-oxide-semiconductor devices with a minimum amount of modeling. The method is analyzed using TCAD simulations, and illustrated with the measurements on n-type silicon-on-insulator FinFETs. The results indicate that the trap density can be extracted between ~0.65 and 0.90 eV. This range is limited by resolution issues at the lowest current levels, and by the transition from subthreshold to saturation behavior at the high current levels.
Molecular and Pharmacologic Properties of the Anticancer Quinolone Derivative Vosaroxin: A New Therapeutic Agent for Acute Myeloid Leukemia (2016)

Vosaroxin is a first-in-class anticancer quinolone derivative that targets topoisomerase II and induces site-selective double-strand breaks in DNA, leading to tumor cell apoptosis. Vosaroxin has chemical and pharmacologic characteristics distinct from other topoisomerase II inhibitors due to its quinolone scaffold. The efficacy and safety of vosaroxin in combination with cytarabine were evaluated in patients with relapsed/refractory acute myeloid leukemia (AML) in a phase III, randomized, multicenter, double-blind, placebo-controlled study (VALOR). In this study, the addition of vosaroxin produced a 1.4-month improvement in median overall survival (OS; 7.5 months with vosaroxin/cytarabine vs. 6.1 months with placebo/cytarabine; hazard ratio [HR] 0.87, 95 % confidence interval [CI] 0.73-1.02; unstratified log-rank p [Formula: see text] 0.061; stratified log-rank p [Formula: see text]0.024), with the greatest OS benefit observed in patients ≥60 years of age (7.1 vs. 5.0 months; HR 0.75, 95 % CI 0.62-0.92; p [Formula: see text]0.003) and patients with early relapse (6.7 vs. 5.2 months; HR 0.77, 95 % CI 0.59-1.00; p [Formula: see text] 0.039), two AML patient groups that typically have poor prognosis. Here we review the chemical and pharmacologic properties of vosaroxin, how these properties are distinct from those of currently available topoisomerase II inhibitors, how they may contribute to the efficacy and safety profile observed in the VALOR trial, and the status of clinical development of vosaroxin for treatment of AML.