gebhart/patrepeval huggingface dataset:
Stent-Supported Reconstruction of the Aortoiliac Bifurcation With the Kissing Balloon Technique (1999)

Background —Bilateral iliac artery obstructions involving the aortic bifurcation or high-grade stenosis of the abdominal aorta are not usually considered an indication for percutaneous treatment. The purpose of the present study was to evaluate the initial and long-term results of primary stent implantation for reconstruction of the aortic bifurcation. Methods and Results —In 48 patients with obstructions of the aortoiliac segment, primary stent implantation was performed with the “kissing balloon technique.” Preinterventional angiography showed bilateral stenoses (&gt;85%) of the proximal common iliac arteries in 25 patients, unilateral occlusions and contralateral stenosis in 22 patients, and bilateral occlusion in 1 patient. In 7 cases, stents were placed for the treatment of high-grade infrarenal aortic stenoses. After excimer laser–assisted recanalization of the common iliac artery obstructions, the aortic bifurcation was reconstructed with the bilateral simultaneous implantation of Palmaz stents (diameter, 7 to 8 mm). Stents used for the treatment of aortic stenoses (Palmaz, n=6; Gianturco, n=1) had a diameter ranging from 20 to 25 mm. In all patients, stents were placed successfully (residual stenosis &lt;30%) and without complications. A clinical improvement of +2 to +3 according to American Heart Association criteria was observed in 41 and 7 patients, respectively. Follow-up was performed clinically (standardized treadmill testing and color-coded Doppler ultrasound) and angiographically. The primary angiographic patency rate (24-month follow-up) was 86.8%. In 3 patients, angiography revealed significant restenoses, which were successfully treated with percutaneous transluminal angioplasty. Conclusions —Primary stent implantation with the kissing balloon technique is safe and effective for the treatment of aortoiliac obstructions involving the aortic bifurcation and represents a true endovascular alternative to surgery.
An Electromagnetically Controllable Microrobotic Interventional System for Targeted, Real‐Time Cardiovascular Intervention (2022)

Robotic magnetic manipulation systems offer a wide range of potential benefits in medical fields, such as precise and selective manipulation of magnetically responsive instruments in difficult-to-reach vessels and tissues. However, more preclinical/clinical studies are necessary before robotic magnetic interventional systems can be widely adopted. In this study, a clinically translatable, electromagnetically controllable microrobotic interventional system (ECMIS) that assists a physician in remotely manipulating and controlling microdiameter guidewires in real time, is reported. The ECMIS comprises a microrobotic guidewire capable of active magnetic steering under low-strength magnetic fields, a human-scale electromagnetic actuation (EMA) system, a biplane X-ray imaging system, and a remote guidewire/catheter advancer unit. The proposed ECMIS demonstrates targeted real-time cardiovascular interventions in vascular phantoms through precise and rapid control of the microrobotic guidewire under EMA. Further, the potential clinical effectiveness of the ECMIS for real-time cardiovascular interventions is investigated through preclinical studies in coronary, iliac, and renal arteries of swine models in vivo, where the magnetic steering of the microrobotic guidewire and control of other ECMIS modules are teleoperated by operators in a separate control booth with X-ray shielding. The proposed ECMIS can help medical physicians optimally manipulate interventional devices such as guidewires under minimal radiation exposure.
Mooring Dynamics Phenomena Due to Slowly-Varying Wave Drift (2002)

The effects of slowly-varying wave drift forces on the nonlinear dynamics of mooring systems have been studied extensively in the past 30 years. It has been concluded that slowly-varying wave drift may resonate with mooring system natural frequencies. In recent work, we have shown that this resonance phenomenon is only one of several possible nonlinear dynamic responses of mooring systems to slowly-varying wave drift excitation. We were able to reveal new phenomena based on the design methodology developed at the University of Michigan for autonomous mooring systems and treating slowly-varying drift as an external time-varying force. In this paper, the U of M methodology is used systematically to reveal seven phenomena induced by mean and slowly-varying drift forces; one of those is resonance. Conceptually, numerous qualitatively different behaviors may be induced. The next step towards comprehensive identification of such phenomena is taken by introducing the method of harmonic balance to study nonautonomous mooring systems.
Mechanical and thermal properties of epoxy resins with reversible crosslinks (1990)

Abstract The tensile properties: Young's modulus, ultimate tensile strength, ultimate elongation, the glass transition temperature, and the dynamic mechanical properties (dynamic shear modulus ( G '), loss tangent (Tan δ)), of three epoxy resins (Epon 828, Epon 836, Epon HPT 1071) cured with the disulfide‐containing crosslinking agent—4.4‐dithiodianilme (DTDA) have been characterized. The results show that DTDA is a satisfactory crosslinking agent for the epoxide resins that have been studied as compared to the well‐known curing agent methylene dianiline (MDA). There are no significant differences between the properties of Epon 828 cured with DTDA at stoichiometric ratio (2:1) and Epon 828 cured with DTDA at small amine excess ratio (1.75:1). The glass transition temperature of the cured tetrafunctional epoxy resin Epon HPT 1971 (235°C) is significantly higher than that of difunctional epoxy resins such as Epon 828 ( T g –175°C), but the product is too brittle to be used without plasticizer.
Maternal attitudes towards prenatal diagnosis of idiopathic clubfoot (2011)

The diagnosis of clubfoot is still often missed during routine ultrasound examination. When a prenatal diagnosis is made, most mothers appreciate having this information. However, when prenatal diagnosis is missed, a significant proportion of mothers seem to accept the false-negative diagnosis retrospectively.
Miniaturization of Magnetic Suspension System with Laterally Control Flux-path Mechanism (2020)

A magnetic suspension system using rotational flux-path control mechanism is developed. In the developed fluxpath control mechanism, a pair of gear-shaped flux control plates are attached to the top and bottom of a permanent magnet (magnetic source); they are surrounded by a ferromagnetic outer yoke with teeth facing the control plates. The gear-shaped control plate is rotated to change the relative angle to the teeth of the outer yoke. The attractive force acting on the ferromagnetic floator is adjusted by rotating the control plates. Stable suspension is achieved in the developed apparatus. It is experimentally shown that the suspension is maintained in the presence of a disturbance.
Total Activation Analysis (1999)

The expression ''total activation analysis'' is used as not only short-lived nuclides are activated within a short irradiation of an actual sample but medium-lived and even longer-lived nuclides as well. By means of a specially designed gamma spectrometry system 1 based on a digital preloaded filter, a loss free-counting LFC! system and a software-based multichannel analyzer, up to 120 loss-corrected and 120 noncorrected spectra of 16 000 channels each may be recorded in a true sequence without recording time gaps, which enables optimization of peak-to-background ratios for each half-life of interest by selective summation of sub-spectra. Thus, a peak on a high Compton continuum may have an optimum signal-to-background ratio after a certain decay time, such as the 1642-keV line of 38 Cl on the Compton edge of the 1779-keV line of 28 Al. The multiple spectra method has a further advantage: By drawing the decay curve, it is possible to easily prove whether only one nuclide contributes to the peak area in question or whether dead-time effects disturb the measurement. An example is the 844-keV 27 Mg contribution of the 848-keV peak of 56 Mn, or a weak 27 Mg peak at 1014 keV at a large Compton continuum.more » Even weak peaks may be used for analysis if the optimal range of spectra is selected.« less
Noise characteristics of a polarization additive pulse modelocked fiber ring laser (2002)

Due to the recent commercialization of erbium doped fiber amplifiers, polarization additive pulse mode-locked (APM) Er-doped fiber lasers are intensively studied as candidates for inexpensive and compact short pulse sources. In most cases, the timing jitter is reported to be greater than several picoseconds. In this paper, we measure the noise characteristics of a polarization APM erbium doped fiber ring laser previously reported. We found its timing jitter to be as low as 144 fsec rms.
Silbertrifluoracetat‐initiierte Reaktionen von Chlortriphenylallen mit Cyclopentadien — Vinylkation‐analoge Cycloadditionen von Allenylkationen (1985)

Abstract Chlortriphenylallen ( 8 ) reagiert mit Cyclopentadien in Gegenwart äquimolarer Mengen Silbertri‐fluoracetat zu einem Gemisch von Trifluoressigsäureestern, deren Hydrolyse die Alkohole 16 – 21 ergibt. Das intermediär gebildete Triphenylallenyl‐Kation ( 9 ) wird hierbei ausschließlich am sp‐Terminus angegriffen und geht mit Cyclopentadien Additions‐ sowie [2 + 2]‐ und [4 + 2]‐ Cycloadditionsreaktionen ein. Die experimentell beobachteten Lanthaniden‐induzierten chemischen Verschiebungen der Protonen der Alkohole 17 – 21 stimmen gut mit den nach der McConnell‐Gleichung berechneten Werten überein.
Ex vivo carbon monoxide delivery inhibits intimal hyperplasia in arterialized vein grafts (2010)

Ex vivo treatment of vein grafts in CO-saturated LR preserved VEC integrity perioperatively and significantly reduced neointima formation. These effects appear to be mediated through the activation of the HIF1α/VEGF pathway.
Associations between the school food environment, student consumption and body mass index of Canadian adolescents (2014)

The results of this study provide further evidence to support the important role of schools in shaping adolescents' dietary habits. Availability and consumption of SSBs, but not less healthful foods, at school were associated with higher adolescent obesity highlighting that other environments also contribute to adolescent obesity.
Importance of Iron Chelation in Free Radical-Induced Oxidative Stress and Human Disease (2011)

Iron is a redox active metal involved in the oxidation-reduction reactions and regulation of cell growth and differentiation. Iron is an integral part of many proteins and enzymes that maintains various physiological functions. Most of the human body's iron is contained in red blood cells. Despite iron being an abundant trace metal in food, millions of people worldwide suffer from anemia. Iron deficiency results in impaired production of iron-containing proteins and inhibition of cell growth. In contrast, abnormal iron uptake has been related to the most common hereditary disease hemochromatosis, leading to tissue damage derived from free radical toxicity. In addition, disruption of iron regulation plays a key role in the etiology of Alzheimer's disease, Parkinson's disease, Huntington's disease, Friedreich's ataxia and other neurological disorders, cancer (lung cancer, breast cancer, colon cancer), Fanconi anemia, stroke and ageing. Thus the control of this necessary but potentially toxic substance is an important part of many aspects of human health and disease. The most frequent is the toxic role of iron linked with the catalytic decomposition of hydrogen peroxide (Fenton reaction) leading to the formation of reactive oxygen species (ROS) causing damage to biomolecules, including lipids, proteins and DNA. The binding of iron-designed chelators via nitrogen, oxygen or sulphur donor atoms blocks iron s ability to catalyze the formation of free radicals. Thus the design of various metal chelators to prevent free radical reactions is an important approach in the treatment of many iron-related diseases. The development of effective dual functioning antioxidants, possessing both metal-chelating and free radical-scavenging properties is awaited. The aim of this review is to discuss the role of iron and importance of iron-chelation in human disease and ageing.
Biodynamic imaging for artificial reproductive technology (2015)

Three-dimensional optical imaging of cellular motion, without the use of fluorescent labels, could provide a non-invasive means to assess the viability of oocytes and embryos prior to transfer for applications in artificial reproductive technology. Biodynamic imaging (BDI) combines laser ranging with digital holography to generate three-dimensional images of tissue-scale motion inside living tissue. The holographic detection process has interferometric sensitivity to nanoscale displacements associated with cellular motion because coherent speckle images consist of a field of interference speckles, each behaving like an individual interferometer (first column of the image). Temporal speckle fluctuations encode a broad range of frequencies related to the Doppler effect caused by intracellular motion. Metabolically active tissue displays high temporal contrast. The comparisons shown show two cumulus-oocyte complexes (COCs). These optical coherence images show similar speckle density, yet one COC displays an active core inside the cumulus shell whereas the other does not (both of which represent the oocyte [highlighted by the dashed area in the mid-section and in the volumetric 3D reconstruction]). Such biodynamic imaging uses light irradiances lower than in conventional optical microscopes, and can be performed remotely through optical windows into incubators, minimizing handling of the samples. DAVID NOLTE* Purdue University 525 Northwestern Ave. West Lafayette, IN 47907 U.S.A. Animated Dynamics 1281 Win Hentschel Blvd West Lafayette, IN 47907 U.S.A. E-mail: dnolte@anidyn.com JOHN TUREK* Purdue University Brown University, Providence RI USA Basic Medical Sciences West Lafayette, IN 47907 U.S.A. RANAN* Animated Dynamics 1281 Win Hentschel Blvd West Lafayette, IN 47906 U.S.A.
Novelties in biomarkers for the management of circulatory failure (2013)

Because of the tight association between circulatory and renal failure, we put a special emphasis on cardiovascular [B-type natriuretic peptide (BNP), Nt-proBNP, troponin, QSOX-1, sST-2, mid-regional pro-atrial natriuretic peptide] and renal biomarkers (neutrophil gelatinase-associated lipocalin, cystatin C, liver-type fatty acid-binding protein, kidney injury molecule-1, insulin-like growth factor-binding protein-7, tissue inhibitor of metalloproteinase-2). We also discuss nonspecific biomarkers (pro-ADM, glycemia, MicroRNA, chromogramin A) in this setting. We discuss the potential interest and limits, from diagnosis to prognosis reclassification, of cutting-edge new biomarkers, but also widely available and inexpensive biomarkers, in the particular setting of circulatory failure.
200 W average power, ultrafast fiber CPA with 400 µJ pulse energy at 2 µm central wavelength (2022)

We present an ultrafast high-power coherently combined thulium-based fiber-CPA. The laser system aims to deliver 400 µJ pulse energy at a pulse repetition frequency of 500 kHz. The simultaneous availability of 200 W-class average power and 1 GW-class peak power in the 2 µm wavelength regime will not only be unique in the world of science but also will pave the way to more compact, cost-effective lasers which are ideally suited for high-harmonic generation into the water-window and nonlinear-frequency conversion to the mid-IR and THz spectral range.
Spatially Sparse Beamforming Training for Millimeter Wave MIMO Systems (2017)

To realize high beamforming gain and thus sufficient link budget, millimeter wave (MMW) multiple-input multiple-output (MIMO) systems employ large antenna arrays at both the transmitter and receiver. However, due to the power and cost limitation, only a limited number of radio frequency (RF) chains are available for MMW antenna arrays. In other words, the number of RF chains is far smaller than that of antenna elements. This MMW MIMO setup poses a formidable challenge for channel estimation, which is conventionally required to realize the optimal singular value decomposition (SVD) beamforming. To circumvent the formidable channel estimation, this paper proposes two iterative antenna training schemes for the SVD beamforming in MMW MIMO systems. Relying on the channel reciprocity in time division duplex, the proposed schemes employ power iteration and Lanczos iteration, respectively, to gradually approach the SVD beamforming. During iterations, we only need to estimate several channel-related vectors instead of the MIMO channel matrix. Thanks to the spatial sparsity in MMW channels, the training overheads required by the proposed schemes are moderate. Simulations demonstrate that the proposed schemes outperform the counterpart in terms of performance and training overhead, and can achieve the performance very close to that of the perfect SVD beamforming.
Keloids: Pathophysiology and management (2007)

Keloid formation occurs as a result of abnormal wound healing. Despite the high prevalence of keloids in the general population, they remain one of the more challenging dermatologic conditions to manage. More than a cosmetic nuisance, they are often symptomatic and can have a significant psychosocial burden for the patient. Although multiple treatment modalities exist, no single treatment has proven widely effective. In fact, recurrence following treatment is generally the norm. Combination therapy is likely the optimal strategy. In this review, we highlight the clinical features, pathophysiology and management of keloids.
2. RAPPRESENTAZIONE DEL PAESAGGIO RURALE: IL PASSATO NEL PRESENTE (2009)

In alcuni zone della pianura emiliana ed imolese si evidenzia, a tutt’oggi, il se-gno dell’assetto agricolo fondiario di epoca romana; infatti il tessuto d’impianto della partizione colonica con la suddivisione del territorio in centurie è leggibile sia nella cartografia storica che in quella recente, anche se la lettura non è im-mediatamente percepibile a causa del susseguirsi di modificazioni del territorio che si sono apportate all’impianto originario. &#13;\nI fenomeni sia naturali, quali l’esondazione ricorrente di rivi e torrenti, sia d’origine antropica tra cui il diverso assetto della proprietà fondiaria, le diverse tecniche di coltivazione dei terreni, hanno portato in questo lungo periodo di tempo cambiamenti al sistema infrastrutturale dei luoghi.&#13;\nDal XVII secolo si manifesta l'esigenza di definire i limiti delle proprietà ed i confini giuridici impongono di descrivere il territorio non solo con scritti, ma an-che con rappresentazioni grafiche di cui i Cabrei ed i catasti storici rappresentano la documentazione più preziosa per individuare ed evidenziare le “regole” della partizione fondiaria, fornendo quindi l’interpretazione di ciò che si potrebbe defi-nire "archeologia del paesaggio" dell'era moderna. Cabrei e catasti storici rappre-sentano il passaggio tra la rappresentazione grafico-pittorica del paesaggio e la moderna cartografia basata su sistemi di coordinate geografiche e proiezioni. &#13;\nOpportuni accorgimenti di lettura delle diverse rappresentazioni cartografiche permettono di confrontare ed analizzare l'entità della trasformazione subita dal territorio rurale negli ultimi quattro secoli. Di conseguenza il confronto tra le rap-presentazioni di alcuni luoghi del passato descritti nei Cabrei e Catasti storici ed immagini recenti sia cartografiche che fotografiche del medesimo luogo succede-ranno ad opportune descrizioni dell’evoluzione dell'assetto fondiario oltre ai con-tenuti degli strumenti disponibili per una lettura in crono sequenza di un deter-minato territorio.
Prone position in mechanically-ventilated patients. (1998)

The prone position, initially introduced into respiratory therapy to improve the drainage of secretions, has been suggested to improve oxygenation in anaesthetized and paralysed subjects. Here we report on the results obtained using the prone position in 17 normal subjects, 10 obese subjects and 16 patients with acute respiratory failure (ARF). In normal subjects, the prone position did not alter respiratory system compliance (Crs,st, 80.9 +/- 16.6 versus 75.9 +/- 13.2 mL.cmH2O-1), while it did improve arterial oxygen tension (Pa,O2, 21.3 +/- 4.9 versus 26.5 +/- 2.1 kPa, p < 0.01), this improvement being paralleled by an increase in functional residual capacity (FRC, 1.935 +/- 0.576 versus 2.921 +/- 0.681 L, p < 0.01). In obese subjects, the FRC (0.894 +/- 0.327 versus 1.980 +/- 0.856 L, p < 0.01) and the lung compliance (CL,st, 91.4 +/- 55.2 versus 109.6 +/- 52.4 mL.cmH2O-1, p < 0.01) increased in the prone position, while the chest wall compliance (Ccw,st, 199.5 +/- 58.7 versus 160.5 +/- 45.4 mL.cmH2O-1, p < 0.01) decreased and the Crs,st remained substantially unaffected (55.4 +/- 9.6 versus 59.6 +/- 12.1 mL.cmH2O-1). In these subjects, the improvements in FRC and CL,st were always paralleled by an increase in Pa,O2 (17.3 +/- 4.1 versus 24.1 +/- 3.7 kPa, p < 0.01). In ARF patients, no difference between the supine and prone position was found either in FRC (1.17 +/- 0.41 versus 1.29 +/- 0.57 L), or in Crs,st (38.4 +/- 13.7 versus 35.9 +/- 10.7 mL.cmH2O-1) or CL,st (52.4 +/- 23.3 versus 53.9 +/- 23.6 mL.cmH2O-1) despite a significant reduction in Ccw,st being observed (204.8 +/- 97.4 versus 135.9 +/- 52.5, p < 0.01). In this group of patients, the use of the prone position resulted in a significant increase in Pa,O2 (13.7 +/- 3.2 versus 17.2 +/- 4.4 kPa, p < 0.05), being the oxygenation improvement induced by the prone position relative to the baseline Ccw,st, according to the relationship: Pa,O2 = -32.4 + (0.24 x Ccw,st); r = 0.82, p < 0.01). The mechanisms which can be hypothesized to justify the modifications reported above are discussed.
Transforming growth factor‐β3 regulates transdifferentiation of medial edge epithelium during palatal fusion and associated degradation of the basement membrane (1997)

Studies on transforming growth factor β3 (TGF-β3) deficient mice have shown that TGF-β3 plays a critical role in palatogenesis. These null mutant mice have clefting of the secondary palate, caused by a defect in the process of fusion of the palatal shelves. A critical step in mammalian palatal fusion is removal of the medial edge epithelial cells from the midline seam and formation of continuous mesenchyme. To determine in more detail the role of TGF-β3 in palatogenesis, we cultured TGF-β3 null mutant and wild-type control palatal shelves in an organ culture system. The fate of the medial edge epithelial cells was studied in vitro using vital cell labeling and immunohistochemical techniques. Despite clear adherence, the null mutant palatal shelves did not fuse in vitro, but instead the medial edge epithelial cells survived at the midline position, and the basement membrane was resistant towards degradation. Supplementation of the culture medium with the mature form of TGF-β3 was able to fully correct the defective fusion in the null mutant specimens. Our results demonstrate that the reason for the defective palatal fusion in TGF-β3 (−/−) samples is not impaired adhesion. Our data define a specific role for TGF-β3 in the events that control transdifferentiation of the medial edge epithelial cells including degradation of the underlying basement membrane. Dev. Dyn. 209:255–260, 1997. © 1997 Wiley-Liss, Inc.
Publisher’s Note: Bridging Multiferroic Phase Transitions by Epitaxial Strain inBiFeO3[Phys. Rev. Lett.105, 057601 (2010)] (2010)

with an incorrect figure and caption. The sixth line of the caption should read as ''triangles) and after annealing at 1023 K . .
Time course of anosmia and dysgeusia in patients with mild SARS-CoV-2 infection (2020)

Click to increase image sizeClick to decrease image size Disclosure statementNo potential conflict of interest was reported by the author(s).