gebhart/patrepeval huggingface dataset:
Endogenous Binding of Steroid Molecules to DNA Nucleotides by a Ca2+/PO4- Process to Enable Gene Transcription (2020)

Steroid hormones, such as cortisol, testosterone and estrogen, have powerful control over human physiology, growth, and reproduction, but efforts to deploy its potential, such as with glucocorticoids, a first-line defense of inflammation, are often met with severe side effects. Unfortunately, much is unknown about the basic interaction of steroid molecules with DNA, including its receptors, activators, factors, and the gene transcription procedure. In this research article, a remarkable finding is shown for the first time, in which it is illustrated through structural analysis that the base pairings of the four DNA nucleotides, adenine with thymine (A-T) and cytosine with guanine (C-G), form perfectly the classic four ring structure of the steroid molecule, which indicates the profound result put forth in this article that steroid molecules bind directly to DNA for the purpose of gene transcription. Further, critical to a basic understanding of DNA, it is resolved here of the location of the unusual ``missing" hydrogen bond of the A-T and T-A pairings, which has only two internal hydrogen bonds whereas C-G and G-C have three hydrogen bonds. It is shown that the third hydrogen bond for A-T and T-A is formed when the A-T and T-A nucleotides are coupled with corticosteroids, such as cortisol, which has an oxygen functional group that is perfectly positioned to form a hydrogen bond with the accessible oxygen-based functional group of thymine. In addition, to facilitate the binding process, it is shown that Ca$^{2+}$ ions, which are associated with the ligand binding domain of the steroid receptor prior to its association with DNA, couple the oxygen-based functional groups at each end of the steroid molecule with the PO$_4^-$ ions of adjacent nucleotides and thus bind the steroid molecule directly to the nucleic acid. Additionally, the basis of initiating the transcription process is described in which the energy stabilization due to the binding of the ion-steroid complex to DNA is dissipated through the DNA molecule to initiate strand separation locally by increasing the length of hydrogen bonds, thus allowing RNA polymerase action. The results are further amplified by analysis of the cortisol hormone and the ligand binding domain of the glucocorticoid receptor in its interaction with the A-T nucleotide pairing.
High resolution mapping of consistent leiomyoma breakpoints in chromosomes 12 and 14 to 12q15 and 14q24.1 (1990)

A substantial percentage of uterine leiomyomas are cytogenetically characterized by consistent, clonal chromosome abnormalities, including t(12;14)(q14-15;q23-24) and other rearrangements of 12q14-15 that occur without any visible 14q changes. The partly similar banding characteristics of these two regions have hitherto precluded exact mapping of the 12q and 14q breakpoints to any particular band, let alone their assignment to subbands. In the series of four myomas presented here, in which one tumor had inv(12q), two t(12;14), and one a three-way t(7;12;14), we were able to achieve high resolution banding (550 band stage) of the rearranged chromosomes in several metaphases. This enabled us to assign a 12q breakpoint to 12q15 in all tumors and, in the three cases informative in this regard, the 14q breakpoint to 14q24.1. The more precise breakpoint mapping considerably narrows down the area that must be examined with molecular genetic methods in order to identify the gene loci that are rearranged in leiomyomas with 12q and 14q aberrations. It will also help determine to what extent leiomyoma rearrangements of 12q involve the same loci that are affected in 12q changes in other tumor types, e.g., in pleomorphic adenomas of the salivary gland, in lipomas, and in myxoid liposarcomas. At present it seems that the breakpoint in 12q may be cytogenetically identical in the three benign tumors, whereas it in myxoid liposarcomas appears to be more proximal.
LHCf: a Calibration Tool for Cosmic Ray Physics at LHC (2009)

The LHCf detector has been designed to measure the energy spectra of 7, n0 and neutrons produced very forward in the proton-proton collisions at LHC, with 14 TeV center of mass energy. The equivalent energy in the laboratory system (1017 eV) will allow significant improvement in knowledge of the mechanisms important for longitudinal development of Very High Energy Cosmic Ray (VHECR) showers, in a region never directly explored. This paper reports on the status and expected performances of the LHCf experiment, which is ready for the data taking in the very first phase of the LHC running.
Analytical Analysis of the Coverage of a MBSFN OFDMA Network (2008)

In this paper, we develop a novel analytical model to examine the coverage and capacity of MBSFN (MBMS over a single frequency network) OFDMA, proposed to deliver TV services to mobile users in forthcoming 3G LTE networks. First, analytical expression for SINR at a given point in a cell is derived, which takes into account the SFN gain and propagation delay values. Next, the shadowing effect of propagation on MBSFN is considered. In addition, dynamic MBSFN, an advanced MBSFN technique, in which the network cells are dynamically activated based on user traffic, is modelled. Finally, the performance of MBSFN is evaluated based on the proposed analytical model. This includes the investigation of MBSFN related parameters such as the modulation and coding scheme (MCS) values and the length of cyclic prefix, as well as the verification on the accuracy of the proposed model and the impact of shadowing. Dynamic MBSFN is also analyzed and we show its effect on the coverage for different traffic scenarios.
Uptake of calcium by pancreatic islet cell microsomes: inhibition by a monoclonal antibody to heart sarcoplasmic reticulum. (1990)

The uptake of Ca2+ by microsomes is thought to participate in the control of cytosolic Ca2+ activity in the insulin-producing pancreatic B-cell. In order to study such a phenomenon methods were developed to isolate microsomes from rat parotid cells, pancreatic islets and tumoral islet cells of the RINm5F line. In the latter case, a subcellular microsomal fraction was prepared in which the ratio of microsomal/mitochondrial enzyme markers, as well as that of ruthenium red-resistant/sensitive 45Ca2+ uptake was 20 times higher than in the corresponding mitochondrial subcellular fraction. The ATP-dependent net uptake of 45Ca2+ by RINm5F cell microsomes was inhibited at low temperature and by either vanadate or a monoclonal antibody to dog heart sarcoplasmic reticulum. Although the uptake of Ca2+ by microsomes may account for only a minor fraction of ATP consumption, its synarchistic regulation by ATP and Ca2+, at close-to-physiological concentrations, appeared well suited to play a major regulatory role in the control of cytosolic Ca2+ activity in intact islet cells.
Regions, Resources, and Settlement (2011)

The century leading up to Lepanto and above all the long reign of Süleyman the Magnificent (1520–66) marks the so-called Ottoman classical age when the empire's distinctive political and military system took root and flourished. The sultan, lodged in his imperial palace at Topkapı on the seaward tip of old Constantinople, oversaw the decisions of his viziers and officers in the imperial divan, met with petitioners and ambassadors from the furthest corners of his empire and beyond, and personally led his soldiers year after year to distant fronts in Hungary and Persia, where the empire continued to expand decade after decade. His soldiers comprised, on the one hand, the sipahis, or prebendal cavalry, awarded grants of land for military service at the discretion of the sultan, and on the other hand, the Janissaries, the slave soldiers recruited from Balkan children, raised as Muslims and trained in the arts of war. The same slave recruitment provided for an elaborate palace staff and bureaucracy in the imperial capital, while the kadıs, the judge-administrators schooled in Islamic law, oversaw the day-to-day running of the provinces.
ChemInform Abstract: Scytonemin A, a Novel Calcium Antagonist from a Blue‐Green Alga. (1988)

ChemInformVolume 19, Issue 38 Natural Products ChemInform Abstract: Scytonemin A, a Novel Calcium Antagonist from a Blue-Green Alga. G. L. HELMS, G. L. HELMS Dep. Chem., Univ. Hawaii, Honolulu, HI 96822, USASearch for more papers by this authorR. E. MOORE, R. E. MOORE Dep. Chem., Univ. Hawaii, Honolulu, HI 96822, USASearch for more papers by this authorW. P. NIEMCZURA, W. P. NIEMCZURA Dep. Chem., Univ. Hawaii, Honolulu, HI 96822, USASearch for more papers by this authorG. M. L. PATTERSON, G. M. L. PATTERSON Dep. Chem., Univ. Hawaii, Honolulu, HI 96822, USASearch for more papers by this authorK. B. TOMER, K. B. TOMER Dep. Chem., Univ. Hawaii, Honolulu, HI 96822, USASearch for more papers by this authorM. L. GROSS, M. L. GROSS Dep. Chem., Univ. Hawaii, Honolulu, HI 96822, USASearch for more papers by this author G. L. HELMS, G. L. HELMS Dep. Chem., Univ. Hawaii, Honolulu, HI 96822, USASearch for more papers by this authorR. E. MOORE, R. E. MOORE Dep. Chem., Univ. Hawaii, Honolulu, HI 96822, USASearch for more papers by this authorW. P. NIEMCZURA, W. P. NIEMCZURA Dep. Chem., Univ. Hawaii, Honolulu, HI 96822, USASearch for more papers by this authorG. M. L. PATTERSON, G. M. L. PATTERSON Dep. Chem., Univ. Hawaii, Honolulu, HI 96822, USASearch for more papers by this authorK. B. TOMER, K. B. TOMER Dep. Chem., Univ. Hawaii, Honolulu, HI 96822, USASearch for more papers by this authorM. L. GROSS, M. L. GROSS Dep. Chem., Univ. Hawaii, Honolulu, HI 96822, USASearch for more papers by this author First published: September 20, 1988 https://doi.org/10.1002/chin.198838311AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume19, Issue38September 20, 1988 RelatedInformation
The Selectivity for K+ versus Na+ in DNA Quadruplexes Is Dominated by Relative Free Energies of Hydration:  A Thermodynamic Analysis by 1H NMR (1996)

We have studied the competition between Na+ and K+ for coordination by G quartets using the oligonucleotide d(G3T4G3) as a model system. d(G3T4G3) forms a dimeric foldback structure containing three G quartets in the presence of either NaCl or KCl. Proton chemical shifts, which are particular to the species of coordinated ion, have been used to monitor the conversion between the sodium and potassium forms under equilibrium conditions. Analysis of titration experiments indicates that at least two K+ are coordinated by the three quartets of the dimeric molecule, and perfect fits of the data are obtained for two Na+ being displaced by two K+. Our results also indicate that the conversion of [d(G3T4G3)]2 from the sodium to the potassium form is associated with a net free energy change (delta G degrees) of -1.7 +/- 0.15 kcal/mol. It has long been suggested that the greater thermal stability of DNA quadruplex structures in the presence of K+ is primarily a result of the optimal fit of this ion in the coordination sites formed by G quartets. However, a consideration of the relatively small change in free energy associated with the conversion from the sodium to the potassium form and the relatively large difference between the free energy of hydration for Na+ and K+ indicates that this cannot be correct. Rather, the preferred coordination of K+ over Na+ is actually driven by the greater energetic cost of Na+ dehydration with respect to K+ dehydration.
Contribution of Dairy Foods to Energy and Nutrient Intakes in Children and Adults: Analysis of Nhanes 2015–2018 (2021)

Dairy foods are foundational foods in healthy eating patterns. Consumption of dairy foods helps both children and adults meet the recommendations of a variety of essential nutrients. Accordingly, the objective of this study was to determine the contribution of total dairy, milk, cheese, and yogurt to energy and nutrient intake in children and adults. Twenty-four-hour dietary recall data from children age 2–18 (n = 5038) and adults age 19–99 (n = 9813) participating in the National Health and Nutrition Examination Survey (NHANES) 2015–2016 and 2017–2018 were analyzed. Intakes (both absolute amounts and as a percentage of total intake) of energy and nutrients were determined for all food groups using the USDA food category system. Data were generated on an as consumed basis and on a disaggregated basis; the latter approach reallocated energy and nutrients from milk and cheese found in other foods (e.g., pizza) back to the respective dairy food group. Total dairy was defined as milk, cheese, and yogurt in this analysis. On a disaggregated basis, total dairy provided 14.2% and 9.7% of total kcal/d in children and adults, respectively. At current consumption levels, milk, cheese, and yogurt contributed 61.6% of calcium, 65.8% of vitamin D, 22.8% of potassium, 23.7% of protein, 38.5% of vitamin A, 38.3% of vitamin B12, 31.1% of riboflavin, 36.3% of phosphorus, 22.7% of zinc, and 18.1% of magnesium in children, on average. Dairy foods also contributed 19% of total fat, 31.1% of saturated fat, 13.9% of sodium, and 4.7% of added sugar to the diets of children. Similarly, in adults, milk, cheese, and yogurt contributed 49.5% of calcium, 45.9% of vitamin D, 11.6% of potassium, 15.7% of protein, 26.6% of vitamin A, 24.9% of vitamin B12, 18.6% of riboflavin, 25% of phosphorus, 15.5% of zinc, and 9.4% of magnesium to the diet, on average. Total dairy also provided 14.2% of total fat, 24.8% of saturated fat, and 10.1% of sodium in adults. Milk was the top source of calcium and vitamin D in both children and adults. Milk, cheese, and yogurt remain significant sources of key nutrients for children and adults, including three out of the four underconsumed nutrients of public health concern (vitamin D, calcium, and potassium) as defined by the 2020 Dietary Guidelines for Americans. National Dairy Council.
[Conformation properties and pharmacological activity of adrenergic catecholamines]. (1977)

In this study, the authors propose a comparison between conformational properties and pharmacological activity of a series of adrenergic phenethylamines; in particular they conclude that if the alpha adrenergic compounds adopt a gauche conformation, beta adrenergics prefer a trans form.
ChemInform Abstract: Synthesis and Herbicidal Activity of 1,5‐Diarylpyrazole Derivatives. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Nanostructured, Solid-State Organic, Chiral Diels−Alder Catalysts via Acid-Induced Liquid Crystal Assembly (2005)

Nanostructured, heterogeneous, chiral Diels−Alder catalysts that are entirely organic in nature were prepared by synthesizing a polymerizable chiral imidazolidinone derivative (1). Acidification of 1 simultaneously activates the catalyst and allows the molecule to form different lyotropic liquid crystal phases. Subsequent photo-cross-linking affords nanoporous organic solids with good active site access and high enantioselectivities.
Family and Early Adolescent Delinquency: A Comprehensive Sequential Family Control Model∗ (1998)

Are family functioning variables, such as bonding and constraints, proximal intervening variables for the explanation of delinquency? Do marital relations, parental deviant models and structural variables intervene between parents' characteristics, family functioning variables and delinquency? Are the family characteristics which most efficiently explain adolescent delinquency and adult criminality the same as the ones that affect early adolescence offending? Can the explanation of delinquency be improved using a sequential family control model? In order to respond to these questions, a sample of 1029 six years old boys was recruited, and 894 of them were interviewed yearly from the ages of ten to twelve. Fourteen constructs were used to build and test the sequential family control model. They are: mother's childbearing age, socioeco‐nomic disadvantage, family adversity, onset of delinquency, family rebellion, marital relations, parental deviance, parental deviant attitudes, attachment between parents and child, involvement in family activities, supervision, regulations, punishments, and delinquency. Through these constructs, a comprehensive sequential family control model was established.
Solar and Wind Energy Integrated System Frequency Control: A Critical Review on Recent Developments (2023)

A paradigm shift in power systems is observed due to the massive integration of renewable energy sources (RESs) as distributed generators. Mainly, solar photovoltaic (PV) panels and wind generators are extensively integrated with the modern power system to facilitate green efforts in the electrical energy sector. However, integrating these RESs destabilizes the frequency of the modern power system. Hitherto, the frequency control has not drawn sufficient attention due to the reduced inertia and complex control of power electronic converters associated with renewable energy conversion systems. Thus, this article provides a critical summary on the frequency control of solar PV and wind-integrated systems. The frequency control issues with advanced techniques, including inertia emulation, de-loading, and grid-forming, are summarized. Moreover, several cutting-edge devices in frequency control are outlined. The advantages and disadvantages of different approaches to control the frequency of high-level RESs integrated systems are well documented. The possible improvements of existing approaches are outlined. The key research areas are identified, and future research directions are mentioned so that cutting-edge technologies can be adopted, making the review article unique compared to the existing reviews. The article could be an excellent foundation and guidance for industry personnel, researchers, and academicians.
Deep Global-Relative Networks for End-to-End 6-DoF Visual Localization and Odometry (2018)

Although a wide variety of deep neural networks for robust Visual Odometry (VO) can be found in the literature, they are still unable to solve the drift problem in long-term robot navigation. Thus, this paper aims to propose novel deep end-to-end networks for long-term 6-DoF VO task. It mainly fuses relative and global networks based on Recurrent Convolutional Neural Networks (RCNNs) to improve the monocular localization accuracy. Indeed, the relative sub-networks are implemented to smooth the VO trajectory, while global subnetworks are designed to avoid drift problem. All the parameters are jointly optimized using Cross Transformation Constraints (CTC), which represents temporal geometric consistency of the consecutive frames, and Mean Square Error (MSE) between the predicted pose and ground truth. The experimental results on both indoor and outdoor datasets show that our method outperforms other state-of-the-art learning-based VO methods in terms of pose accuracy.
A Platform for Placement of Analog Integrated Circuits Using Satisfiability Modulo Theories (2016)

Satisfiability modulo theories (SMT) is an area concerned with checking the satisfiability of logical formulas over one or more theories. SMT can be well tuned to solve several of the most intriguing problems in electronic design automation (EDA). Analog placers use physical constraints to automatically generate small sections of layout. The work presented in this paper shows that SMT solvers can be used for the automation of analog placement, given some physical constraints. We propose a tool that uses Microsoft Z3 SMT solver to find valid placement solutions for the given analog blocks. Accordingly, it generates multiple layouts that fulfill some given constraints and provides a variety of alternative layouts. The user has the option to choose one of the feasible solutions. The proposed system uses the quantifier-free linear real arithmetic (QFLRA), which makes the problem decidable. The proposed system is able to generate valid placement solutions for benchmarks. For benchmarks that have many constraints and few geometries, the proposed system achieves a speedup that is 10 times faster than other recently used approaches.
Capacity of wireless ad-hoc networks under multipacket transmission and reception (2008)

In this paper we deduce the capacity of wireless adhoc networks under the assumptions of physical model for cooperative multiple input multiple output (MIMO) communication. We show that the capacity of a random wireless ad-hoc network can be improved significantly by adopting MIMO techniques. In particular, when the nodes are endowed with multi-packet transmission and reception capabilities, the per session capacity increases at least as n <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1-2/alpha</sup> R(n) <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3-4/alpha</sup> , where alpha > 2 is the path loss parameter and R(n) is the range of cooperation. The proof for the above results utilizes an edge coloring of an appropriately chosen random geometric graph. This approach, as a by product, provides alternative deductions for some previously established results under the physical model. Consequently, we provide an alternative deduction of the classical result for a point to point communication by Gupta and Kumar. Furthurmore, we also deduce a bound that matches a recent result by Wang et. al., for capacity of ad-hoc networks under multipacket reception, within a poly-log factor.
Book Review of Powder Diffraction: Theory and Practice (2009)

ADVERTISEMENT RETURN TO ISSUEPREVBook ReviewBook Review of Powder Diffraction: Theory and PracticeJames A KadukView Author Information INEOS Technologies, Naperville, ILCite this: Cryst. Growth Des. 2009, 9, 5, 2537–2538Publication Date (Web):March 11, 2009Publication History Received4 February 2009Published online11 March 2009Published inissue 6 May 2009https://pubs.acs.org/doi/10.1021/cg9001303https://doi.org/10.1021/cg9001303book-reviewACS PublicationsCopyright © 2009 American Chemical SocietyRequest reuse permissionsArticle Views558Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Chemical structure,Granular materials,Mathematical methods,Physical and chemical processes,Space group Get e-Alerts