gebhart/patrepeval huggingface dataset:
A framework for predicting trajectories using global and local information (2014)

We propose a novel framework for predicting the paths of vehicles that move on a road network. The framework leverages global and local patterns in spatio-temporal data. From a large corpus of GPS trajectories, we predict the subsequent path of an in-progress vehicle trajectory using only spatio-temporal features from the data. Our framework consists of three components: (1) a component that abstracts GPS location data into a graph at the neighborhood or street level, (2) a component that generates policies obtained from the graph data, and (3) a component that predicts the subsequent path of an in-progress trajectory. Hierarchical clustering is used to construct the city graph, where the clusters facilitate a compact representation of the trajectory data to make processing large data sets tractable and efficient. We propose four alternative policy generation algorithms: a frequency-based algorithm (FreqCount), a correlation-based algorithm (EigenStrat), a spectral clusteringbased algorithm (LapStrat), and a Markov Chain-based algorithm (MCStrat). The algorithms explore either global patterns (FreqCount and EigenStrat) or local patterns (MCStrat) in the data, with the exception of LapStrat which explores both. We present an analysis of the performance of the alternative prediction algorithms using a large real-world taxi data set.
Structural and Functional Role of the Disulfide Bridges in the Hydrophobin SC3 (2000)

Hydrophobins function in fungal development by self-assembly at hydrophobic-hydrophilic interfaces such as the interface between the fungal cell wall and the air or a hydrophobic solid. These proteins contain eight conserved cysteine residues that form four disulfide bonds. To study the effect of the disulfide bridges on the self-assembly, the disulfides of the SC3 hydrophobin were reduced with 1,4-dithiothreitol. The free thiols were then blocked with either iodoacetic acid (IAA) or iodoacetamide (IAM), introducing eight or zero negative charges, respectively. Circular dichroism and infrared spectroscopy showed that after opening of the disulfide bridges SC3 is initially unfolded. IAA-SC3 did not self-assemble at the air-water interface upon shaking an aqueous solution. Remarkably, after drying down IAA-SC3 or after exposing it to Teflon, it refolded into a structure similar to that observed for native SC3 at these interfaces. Iodoacetamide-SC3 on the other hand, which does not contain extra charges, spontaneously refolded in water in the amyloid-like beta-sheet conformation, characteristic for SC3 assembled at the water-air interface. From this we conclude that the disulfide bridges of SC3 are not directly involved in self-assembly but keep hydrophobin monomers soluble in the fungal cell or its aqueous environment, preventing premature self-assembly.
Measuring and Modeling Emissions from Extremely Low-Emitting Vehicles (2006)

In recent years, automobile manufacturers have been producing gasoline-fueled vehicles that have very low tailpipe and evaporative emissions to meet stringent certification standards set by the U.S. Environmental Protection Agency and the California Air Resources Board. These extremely low-emitting vehicles are 98% to 99% cleaner than the catalyst-equipped vehicles produced in the mid-1980s. To understand better the emissions characteristics of these extremely low-emitting vehicles, as well as their potential impact on future air quality, researchers at the University of California, Riverside, have conducted a comprehensive study consisting of (a) an emissions measurement program, (b) the development of specific emissions models, and (c) the application of future emissions inventories to air quality models. Results have shown that in nearly all cases, these vehicles have emissions that are well below their stringent certification standards, and the vehicles continue to have low emissions as they age. On the basis of the measurement results, new modal emissions models have been created for both ultra-low-emission-certified vehicles and partial-zero-emission-certified vehicles. The model results compare well with actual measurements. With these models, it is possible to predict accurately future mobile source emissions inventories that will have an increasing number of these extremely low-emitting vehicles in the overall vehicle population. It is expected that the large penetration of these vehicles into the vehicle fleet will have a significant role in meeting ozone attainment levels in many regions.
The ecology of the mudhif (2008)

If Eco Architecture is a matter of designing with nature then the Sumerian mudhif is a paradigmatic example. It was first built in the marshes of what is now southern Iraq, over 5000 years ago, and constructed entirely of reeds, to form huge parabolic arches over which reed mats were tied to form walls, curving over into roofs whilst the flat end walls had reed lattice panels for the admission of daylight and air. The mudhif was built and used, by the Marsh Arabs of the region, until 1993 when Saddam Hussein began to drain and dam the marshes, in an attempt to destroy the life and culture of those Arabs. But after his defeat in 2003, the Arabs dug up his dykes, canals and damns, re-flooded the marshes and began to resume their ancient way of life.
10Gbit/s Transmission over Long Distance after All-Optical NRZ and RZ to CSRZ Format Conversion Using SLALOM (2005)

We present a 10Gbit/s transmission performance over long distance after all-optical format conversion between NRZ and RZ to CSRZ format, using a semiconductor laser amplifier in a loop mirror (SLALOM).
Mining Software Repositories for Predictive Modelling of Defects in SDN Controller (2019)

In Software Defined Networking (SDN) control plane of forwarding devices is concentrated in the SDN controller, which assumes the role of a network operating system. Big share of today's commercial SDN controllers are based on \textit{OpenDaylight}, an open source SDN controller platform, whose bug repository is publicly available. In this article we provide a first insight into 8k+ bugs reported in the period over five years between March 2013 and September 2018. We first present the functional components in \textit{OpenDaylight} architecture, localize the most vulnerable modules and measure their contribution to the total bug content. We provide high fidelity models that can accurately reproduce the stochastic behaviour of bug manifestation and bug removal rates, and discuss how these can be used to optimize the planning of the test effort, and to improve the software release management. Finally, we study the correlation between the code internals, derived from the Git version control system, and software defect metrics, derived from Jira issue tracker. To the best of our knowledge, this is the first study to provide a comprehensive analysis of bug characteristics in a production grade SDN controller.
Rapid clearance of rituximab may contribute to the continued high incidence of autoimmune hematologic complications of chemoimmunotherapy for chronic lymphocytic leukemia (2013)

Rituximab is an effective treatment for autoimmune cytopenias associated with chronic lymphocytic leukemia. Despite the incorporation of rituximab into fludarabine-based chemotherapy regimens, the incidence of autoimmune cytopenias has remained high. Inadequate rituximab exposure due to rapid antibody clearance may be a contributing factor. To test this hypothesis, we measured serum rituximab levels in patients treated with fludarabine and rituximab (375 mg/m(2)). All patients had undetectable rituximab trough levels by the end of cycle 1, and one-third had undetectable levels already on Day 6 of cycle 1. Although rituximab trough levels increased progressively with each cycle, only by cycle 4 did the median trough level exceed 10 ug/mL. The median half-life of rituximab during cycle 1 was 27 hours, compared to 199 hours during cycle 4 (P<0.0001). There was a significant inverse correlation between the rituximab half-life in cycle 1 and the degree of tumor burden (P=0.02). Two patients who were identified as having subclinical autoimmune hemolysis prior to therapy were given additional doses of rituximab during the initial cycles of therapy and did not develop clinically significant hemolysis. One patient who developed clinically significant hemolysis during therapy was given additional rituximab doses during cycles 3-5 and was able to successfully complete his treatment. In conclusion, rituximab is cleared so rapidly during the initial cycles of therapy for chronic lymphocytic leukemia that most patients have only transient serum levels. More frequent dosing of rituximab may be required to prevent autoimmune complications in at-risk patients (clinicaltrials.gov identifier:00001586).
Permeation of Piroxicam from the Poloxamer Gels (1999)

Topical formulations of piroxicam were prepared using poloxamer 407 or poloxamer 188 by a cold method, and the permeation characteristics of piroxicam were evaluated. The permeation rate of piroxicam across the synthetic cellulose membrane and the rat skin decreased as the concentration of poloxamer increased. Though poloxamer gel exhibits reversed thermal behavior, the permeation rate of piroxicam increased with increasing temperature, indicating that the diffusional pathway of piroxicam is a water channel within the gel formulation. The pH of the gel did not affect the permeation rate of piroxicam significantly. As the concentration of piroxicam in the gel formulation increased, the permeation rate of piroxicam increased up to 1% and reached a plateau above 1%. Among various enhancers tested, polyoxyethylene-2-oleyl ether showed the highest enhancing effect, with an enhancement ratio of 2.84. Based on experimental results, the permeation rate of piroxicam can be controlled by changing the poloxamer concentration or drug concentration and by the addition of an appropriate enhancer.
A mineralogical re-use classification model of molasse rock mass in the Geneva Basin (2020)

This is a conference proceedings article as part of the EUROCK2020 conference in Trondheim, Norway and part of the PhD study on MATEX (excavated material) on behalf of the FCC study.
Effect of age and gender on the progression of adult vascular dysfunction in a mouse model of fetal programming lacking endothelial nitric oxide synthase (2011)

The objective of this study was to investigate vascular function at different ages in a transgenic murine model of fetal vascular programming using a model of uteroplacental insufficiency induced by lack of endothelial nitric oxide synthase. Homozygous NOS3 knockout (KO) and wild-type (WT) mice were cross bred to produce WT, KO, and heterozygous that developed in WT (KOP) or KO (KOM) mothers. Male/female offspring from the four groups were killed at 7, 14, and 21 wk of age (n = 5-10/group), and carotid arteries were used for in vitro vascular studies. Responses to phenylephrine (PE), with/without N(G)-nitro-L-arginine methyl ester (L-NAME), angiotensin (ANG), acetylcholine (ACh), sodium nitroprusside, and isoproterenol (ISO) were studied. At 7 wk, only KO offspring showed higher contractile response to PE, whereas, at 14 and 21 wk, both KO and KOM had a higher response. Incubation with L-NAME abolished these differences. ANG contraction was higher in male KO in all age groups and in 21-wk-old females. Relaxation to ACh and ISO was absent in KO, and significantly decreased in KOM offspring in all age groups compared with KOP and WT, independent of gender. Sodium nitroprusside was not different between groups. The effect of the altered intrauterine environment on the development of abnormal vascular function was limited at 7 wk of age and most evident at 14 wk; further deterioration was limited to ANG-mediated vascular contractility in KO offspring. Our findings provide some hope that at least the first seven postnatal weeks may be an appropriate therapeutic window to prevent cardiovascular disease later in life.
[Research on heterocyclic compounds. VI. Imidazo(1,2-b)pyridazine derivatives]. (1977)

Electrodeless streamer inception on an epoxy surface under AC voltage stress was investigated for different gas compositions and pressures, with a focus on the pressure region below 1 bar. For this purpose, we used a set-up with cylindrical electrodes embedded out-of-axis in a cylindrical epoxy rod. Experiments were performed in N2, SF6, ambient air, Ar and CO2. The discharge inception voltage was measured, from which the critical value K of the ionization integral was reconstructed assuming a non-disturbed Laplacian field distribution. We have validated that for electropositive gases Ar an N2 the generally assumed value of K = 10 is in good agreement with our measurements. For electronegative gases, however, the experimentally obtained values turned out to be considerably higher. We attribute this discrepancy mainly to the statistical time delay of the first electron; to increase the probability of discharge inception in a critical region, it was necessary to extend the critical area by means of applying an overvoltage to the system.
The Cellvibrio japonicus Mannanase CjMan26C Displays a Unique exo-Mode of Action That Is Conferred by Subtle Changes to the Distal Region of the Active Site (2008)

The microbial degradation of the plant cell wall is a pivotal biological process that is of increasing industrial significance. One of the major plant structural polysaccharides is mannan, a beta-1,4-linked d-mannose polymer, which is hydrolyzed by endo- and exo-acting mannanases. The mechanisms by which the exo-acting enzymes target the chain ends of mannan and how galactose decorations influence activity are poorly understood. Here we report the crystal structure and biochemical properties of CjMan26C, a Cellvibrio japonicus GH26 mannanase. The exo-acting enzyme releases the disaccharide mannobiose from the nonreducing end of mannan and mannooligosaccharides, harnessing four mannose-binding subsites extending from -2 to +2. The structure of CjMan26C is very similar to that of the endo-acting C. japonicus mannanase CjMan26A. The exo-activity displayed by CjMan26C, however, reflects a subtle change in surface topography in which a four-residue extension of surface loop creates a steric block at the distal glycone -2 subsite. endo-Activity can be introduced into enzyme variants through truncation of an aspartate side chain, a component of a surface loop, or by removing both the aspartate and its flanking residues. The structure of catalytically competent CjMan26C, in complex with a decorated manno-oligosaccharide, reveals a predominantly unhydrolyzed substrate in an approximate (1)S(5) conformation. The complex structure helps to explain how the substrate "side chain" decorations greatly reduce the activity of the enzyme; the galactose side chain at the -1 subsite makes polar interactions with the aglycone mannose, possibly leading to suboptimal binding and impaired leaving group departure. This report reveals how subtle differences in the loops surrounding the active site of a glycoside hydrolase can lead to a change in the mode of action of the enzyme.
High power density, 60 Hz, single flow steam turbine with 42 inch titanium last row blade for advanced combined cycle applications (1999)

Highly efficient, yet economical steam turbines with large exhaust areas and increased inlet pressure and temperature capability are required to complement the growth in combustion turbine power ratings and address the pursuit of higher combined cycle plant efficiencies. This paper discussed the design of a 130--190MW, 60 Hz steam turbine which addresses these requirements for 2 x 1F, 1 x 1G and Advanced Turbine Study (ATS) combined cycle plants. Features of interest include a compact, two casing, axial exhaust, single flow design with a two piece, welded IP-LP rotor and 42 inch titanium last row blade.
Sodium bicarbonate cotransporter NBCn1/Slc4a7 affects locomotor activity and hearing in mice (2020)

Despite a widespread expression pattern in the central nervous system, the role of the sodium bicarbonate cotransporter NBCn1/Slc4a7 has not been investigated for locomotor activity, emotion and cognition. Here, we addressed the behavioral consequences of NBCn1 knockout and evaluated hearing and vision that are reportedly impaired in an earlier line of NBCn1 knockout mice and may contribute to behavioral changes. In a circular open field, the knockout mice traveled a shorter distance, especially in the periphery of the chamber, than wildtype littermates. The knockout mice also traveled a shorter total distance in a home cage-like open field. Rearing and grooming behaviors were reduced. The knockout and control mice displayed similar time spent and number of open and closed arms in the elevated plus maze test, indicating negligible change in anxiety. In the Morris water maze test, both groups of mice learned the location of an escape platform within comparable time on the training trials and showed similar platform identification on the probe trial. The knockout mice maintained normal visual responses in the optokinetic drum and produced evoked potentials in response to light stimuli. However, these mice failed to produce auditory evoked potentials. qPCR revealed a robust expression of an alternatively transcribed NBCn1 variant in the knockout mouse retina. These results indicate that NBCn1 deletion leads to reduced locomotor activity in mice by affecting their exploratory behaviors or emotionality. The deletion also causes hearing loss, but its effect on vision varies between different lines of knockout mice.
Partial recanalization of concomitant internal carotid–middle cerebral arterial occlusions promotes distal recanalization of residual thrombus within 24 h (2010)

More than half of all patients who present with both ICA and MCA occlusions who are only partially recanalized will undergo facilitated endogenous recanalization within the subsequent 24 h following intervention.
Partial splenic embolization (2007)

Partial splenic embolization (PSE) is a non-surgical procedure developed to treat hypersplenism as a result of hepatic disease and thus avoid the disadvantages of splenectomy. A femoral artery approach is used for selective catheterization of the splenic artery. Generally, the catheter tip is placed as distally as possible in an intrasplenic artery. After an injection of antibiotics and steroids, embolization is achieved by injecting 2-mm gelatin sponge cubes suspended in a saline solution containing antibiotics. PSE can benefit patients with thrombocytopenia, esophagogastric varices, portal hypertensive gastropathy, encephalopathy, liver dysfunction, splenic aneurysm, and splenic trauma. The contraindications of PSE include secondary splenomegaly and hypersplenism in patients with terminal-stage underlying disease; pyrexia or severe infections are associated with a high risk of splenic abscess after PSE. Complications of PSE include daily intermittent fever, abdominal pain, nausea and vomiting, abdominal fullness, appetite loss, and postembolization syndrome. Decreased portal-vein flow and a rapid increase in the platelet count after excessive embolization may cause portal-vein or splenic-vein thrombosis.
Human T-cell leukemia virus type I trans activator induces class I major histocompatibility complex antigen expression in glial cells (1990)

Transfection of the tax gene encoding the trans activator of human T-cell leukemia virus type I into glial line cells induced class I major histocompatibility complex (MHC) antigens on these cells. This occurred through the interaction of tax protein with the gene encoding class I MHC antigens but not through any soluble factors, such as interferons, or factors from glial cells. Since neural cells do not usually express MHC antigens, this novel mechanism may be an intermediate event between viral infection and subsequent immune-mediated pathology in the central nervous system.
Neuropeptide Y Prevents Agonist-Stimulated Increases in Contractility (1995)

Neuropeptide Y has been shown to inhibit contractility in the rat heart. Although the reasons for this effect are not known, it is possible that postsynaptic adrenergic mechanisms involving neuropeptide Y may be responsible. To ascertain whether this neuromodulatory effect is possible for decreasing contractility, we investigated the effect of neuropeptide Y on agonist-stimulated contractility of the isolated rat myocardium. Receptor binding studies of purified cardiac membranes showed that incubating membrane in the presence of neuropeptide Y (10(-7) mol/L) decreased the number of alpha-/beta-adrenoceptor binding sites without affecting the affinity of these receptors. Isolated hearts perfused with phenylephrine (10(-5) to 10(-10) mol/L) or isoproterenol (10(-5) to 10(-10) mol/L) in a nonrecirculating Langendorff setup demonstrated a significant increase in contractility over control values, whereas no change in contractility was observed when the hearts were perfused with neuropeptide Y (10(-7) mol/L). However, in the presence of both agonist and neuropeptide Y the increase in contractility previously seen with agonist alone was not evident. Comparisons made with hearts taken from aortic banded rats yielded similar results. Although neuropeptide Y itself was ineffective in decreasing contractility, it prevented the agonists from stimulating contractility when perfused together. We conclude that neuropeptide Y does not directly decrease contractility but prevents agonist-stimulated increases in contractility through alpha-/beta-adrenoceptor pathways. This neuromodulatory effect of neuropeptide Y is unchanged in situations of increased sympathetic activity, such as hypertension.
Migraine triggers in Asian countries: a narrative review (2023)

Majority of the common triggers reported by patients with migraine in Asia were stress and sleep, similar to those reported globally, thus showing they are universally important. Some triggers linked to internal homeostasis are influenced by culture (e.g., alcohol, food/eating habit), and triggers related to environmental homeostasis, such as weather, are highly heterogenous between regions.
Gravity Methods (1990)

This is the completely revised and updated version of the popular and highly regarded textbook, Applied Geophysics. It describes the physical methods involved in exploration for hydrocarbons and minerals, which include gravity, magnetic, seismic, electrical, electromagnetic, radioactivity, and well-logging methods. All aspects of these methods are described, including basic theory, field equipment, techniques of data acquisition, data processing and interpretation, with the objective of locating commercial deposits of minerals, oil, and gas and determining their extent. In the fourteen years or so since the first edition of Applied Geophysics, many changes have taken place in this field, mainly as the result of new techniques, better instrumentation, and increased use of computers in the field and in the interpretation of data. The authors describe these changes in considerable detail, including improved methods of solving the inverse problem, specialized seismic methods, magnetotellurics as a practical exploration method, time-domain electromagnetic methods, increased use of gamma-ray spectrometers, and improved well-logging methods and interpretation.
Hypertension and multiple cardiovascular risk factors increase the risk for retinal vein occlusions (2019)

Cardiovascular risk factors are more important than other risk factors for the presence of RVO. The risk of RVO increased by approximately 40% with any additional risk factor and by 70% with any additional cardiovascular risk factor.