gebhart/patrepeval huggingface dataset:
Modeling the effects of particles, interstitials, vacancies and tip geometry on indentation-induced plasticity (2006)

In this work, which is a follow-up of an earlier work by the authors in this journal, we discuss the effects of particles, interstitials, vacancies and indenter-tip geometry on indentation-induced plasticity. A nano-indentation model based on a close-packed array of straws was used. Upon indentation with a cylindrical indenter, the results observed in situ, match qualitatively computer atomistic and finite-element simulation models. This model helps explain the phenomenon and physical reasons for annihilation of vacancies. It also shows the strong effect of interstitials on the inception of plasticity at their sites. It shows that a rigid particle acts as a stress concentrator even away from the indenter. On indentation with a flat indenter, curling of atoms at the indenter edges was observed, along with slip lines reported in the literature.
Clinical, cytogenetic, and molecular genetic characterization of two unrelated patients with different duplications of 21q (2005)

We present 2 patients with dup(21q). Patient MP01 had mild mental retardation, facial findings characteristic of Down syndrome (DS), and a terminal duplication of chromosome 21. His karyotype was 46,XY,dup(21) (q22.1-qter). Patient MP03 had mild mental retardation, minor anomalies not characteristic of DS, and a duplication of the proximal long arm of chromosome 21, karyotype 46,XX,dup(21) (q11.2-q21.2). The patients were studied with single-copy DNA sequences from 20 loci on chromosome 21 to characterize the extent of the duplicated regions at the DNA level. DNA loci from D21S55 to COL6A1 were triplicated in patient MP01 while loci from D21S13 to D21S8 were triplicated in patient MP03. Our results support the hypothesis of a critical region of chromosome 21, which in triplicate is responsible for many of the facial changes associated with DS. Other genes outside this region may also contribute to other abnormalities observed in DS.
Blind adaptive multiuser detection (1995)

The decorrelating detector and the linear minimum mean-square error (MMSE) detector are known to be effective strategies to counter the presence of multiuser interference in code-division multiple-access channels; in particular, those multiuser detectors provide optimum near-far resistance. When training data sequences are available, the MMSE multiuser detector can be implemented adaptively without knowledge of signature waveforms or received amplitudes. This paper introduces an adaptive multiuser detector which converges (for any initialization) to the MMSE detector without requiring training sequences. This blind multiuser detector requires no more knowledge than does the conventional single-user receiver: the desired user's signature waveform and its timing. The proposed blind multiuser detector is made robust with respect to imprecise knowledge of the received signature waveform of the user of interest.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Prediction of Wine Color Attributes from the Phenolic Profiles of Red Grapes (Vitis vinifera) (2008)

Knowledge about the relation between grape and wine phenolics is of key interest for the wine industry with respect to being able to predict wine quality from analyses of grapes. Prediction of the phenolic composition and color of experimentally produced red wines from the detailed phenolic composition of the corresponding grapes was investigated using a multivariate approach. Grape extracts and wines were produced from 55 different grape samples, covering 8 different Vitis vinifera cultivars: Alicante, Merlot, Syrah, Cinsault, Grenache, Carignan, Cabernet Sauvignon, and Mourvedre. The phenolic composition of the grapes and wines showed that the average ratios between wine and grape phenolics ranged from 0.25 to 7.9 for the different phenolic compounds. Most interestingly, the average ratios were low for anthocyanins (0.31) and tannins (0.32), intermediate for (+)-catechin (0.75) and polymeric pigments (0.98), and high for gallic acid (7.9). Individual wine phenolics in general correlated well with several grape phenolics, indicating that a multivariate approach might be advantageous for prediction of wine phenolics from grape phenolics analysis. However the use of multivariate prediction of individual wine phenolics from the complete grape phenolic composition only improved the prediction of wine polymeric pigments, whereas wine anthocyanins were predicted with the same precision as from the direct relation with grape anthocyanins. Prediction of color attributes of pH normalized experimental wines from the phenolic profiles of grapes was accomplished using a multivariate approach. The correlation between predicted and measured total wine color was high ( r = 0.958) but was very similar to the correlation coefficient obtained for the direct relation between grape anthocyanins and total wine color ( r = 0.961). Color due to copigmentation, color due to anthocyanins, and color intensity were also predicted well.
Structural Control of Cell Permeability with Highly Emissive Europium(III) Complexes Permits Different Microscopy Applications (2015)

Four anionic europium complexes are described based on triazacyclononane tris-carboxylate or phosphinate ligands. In each case, the three sensitising chromophores comprise a substituted aryl-alkynyl pyridine group, with complex brightness in water falling in the range 4 to 23 mM(-1) cm(-1) . para-Substitution of the aryl ring with carboxymethyl groups gives complexes that are taken into cells, stain the lysosomes selectively and unexpectedly permit lifetime measurements of lysosomal pH. In contrast, the introduction of sulfonate groups inhibits cell uptake enabling the Eu complex to be used as an extracellular donor for FRET applications at the membrane surface. Using time-gated FRET microscopy, the cell membrane structure was highlighted, in which Cell Mask Deep Red was used as a membrane- localized FRET acceptor.
Serotonin and Stress: Protective or Malevolent Actions in the Biobehavioral Response to Repeated Trauma? (2004)

Structural hippocampus and prefrontal cortex changes occur in patients with posttraumatic stress disorder (PTSD) that appears correlated with cognitive dysfunction. In these brain regions, serotonin (5HT) plays a prominent role in symptom presentation and treatment of PTSD. However, 5HT is both anxiogenic and anxiolytic, and while 5HT reuptake inhibitors are effective in treatment, the role of 5HT in the development of PTSD remains uncertain. Using a model of repeated trauma in rats, we observed significant spatial memory impairment together with significantly increased 5HT(1A) receptor density (B(max)), decreased 5HT(1A) receptor affinity (K(d)), and significantly increased 5HT(2A) receptor affinity on day 7 poststress. The serotonergic agent fluoxetine (FLX; 10 mg/kg/d ip) administered 1 week before stress and continuing throughout the stress procedure, but not the 5HT depleter p-chloro-phenylalanine (PCPA; 300/100/50 mg/kg/d ip), prevented stress-induced cognitive dysfunction. PCPA, however, reversed stress-induced hippocampal 5HT(1A) receptor affinity changes, with FLX narrowly missing significance. Neither drug reversed stress effects on 5HT(2A) receptor affinity. Thus, 5HT plays an important part in the cognitive-behavioral changes evoked by repeated trauma. That raised 5HT activity may mediate hippocampal 5HT(1A) receptor changes evoked by stress suggests a bidirectional role for 5HT in the development of PTSD.
Figure S1 from Glycodelin: A New Biomarker with Immunomodulatory Functions in Non–Small Cell Lung Cancer (2023)

&lt;p&gt;Figure S1. Survival of females with high PAEP expression.&lt;/p&gt;
Synthesis, insecticidal activity, and mode of action of novel imidazopyridine mesoionic derivatives containing an amido group (2022)

The results reported here contribute to the development of new mesoionic insecticides and further our understanding of the mode-of-action of imidazopyridine mesoionic derivatives. © 2022 Society of Chemical Industry.
2D and 3D millimeter-wave synthetic aperture radar imaging on a PR2 platform (2016)

Optical depth cameras, including both time-of-flight and structured-light sensors, have led to dramatic improvements in robot sensing and perception. We propose the use of millimeter-wave (mmW) radar as an important complement to optical sensors. While the millimeter wavelengths of radar sensors do not support as high resolution as the nanometer wavelength of optical sensors, the ability of mmW signals to penetrate smoky and foggy environments as well as see through many opaque objects makes them a compelling sensor for navigation as well as manipulation in challenging environments. We present a series of 2D and 3D mmW images made with a hand-held antenna grasped by a PR2 robot. The radar image sensor uses a mechanical “painting” motion to acquire multiple views of the target object over the 15 - 26.5 GHz K-band. A GPU-based reconstruction algorithm synthesizes 2D and 3D images of the target object. We demonstrate a ground range resolution of 13.6 mm and a cross-range resolution of 7.1 mm for objects up to 0.5 m away from the robot. We further demonstrate imaging objects through fog, as well as through opaque paper.
The Control of RNA Interference with Light (2013)

RNA interference is a ubiquitous mechanism of gene-expression regulation. By bringing this process under the control of light, the spacing, timing and degree of gene expression can be controlled. In this chapter we explore the variety of ways in which RNA Interference has been brought under the control of light.
Evaluation of biological activities of new LH‐RH antagonists (T‐series) in male and female rats (1993)

A series of new highly potent LH-RH antagonists (T-series) has been synthesized in our laboratory. Among these analogs, antagonists [Ac-D-Nal(2), D-Phe(4Cl)2, D-Pal(3)3, D-Lys(A2pr(Car)2)6, D-Ala10]LH-RH (T-140); [Ac-D-Nal(2)1, D-Phe(4Cl)2, D-Pal(3)3, D-Lys(A2pr(Ac)2)6, D-Ala10]LH-RH (T-148); [Ac-D-Nal(2)1, D-Phe(4Cl)2, D-Pal(3)3, D-Lys(A2pr(For)2)6, D-Ala10]LH-RH (T-151) and [Ac-D-Nal(2)1, D-Phe(4Cl)2, D-Pal(3)3, D-Lys(A2bu(For)2)6, D-Ala10]LH-RH (T-159) were the most powerful. Antagonists T-140, T-148 and T-151 produced a complete blockade of ovulation in normal cycling rats at a dose of 1.5 micrograms/rat and antagonist T-159 at a dose of only 0.75 micrograms/rat. The inhibitory effects of compounds T-148, T-151 and T-159 on gonadotropin and sex steroid secretion were investigated in male and female rats. To determine their effect on LH levels in castrated male and ovariectomized female rats, T-148, T-151 and T-159 were injected subcutaneously in doses of 0.625 and 2.5 micrograms/rat. Blood samples were taken at different intervals for 48 h. All three compounds at either dose caused a significant (P < 0.01) decrease in LH levels for more than 6 h. Significant (P < 0.01) inhibition of LH lasted for more than 24 h following a dose of 2.5 micrograms sc of all 3 antagonists in both male and female rats. Serum FSH levels were also suppressed significantly for more than 48 h in castrated male rats by all three antagonists at a dose of 5 micrograms/rat sc.(ABSTRACT TRUNCATED AT 250 WORDS)
A Novel Packet Queuing and Scheduling Algorithm and Its Link Sharing Performance for the Home Internet Gateway (2009)

A home Internet gateway is the node that resides between a public network and a home network for computers to share Internet connections. To insert customized queuing and scheduling codes into the embedded Linux kernel is a way to make the Linux-based home Internet gateways support Quality of Service(QoS). It is desirable that the small Linux kernel adopts an efficient queuing and scheduling algorithm to support link sharing, priority and traffic shaping. The algorithm presented in this paper is based on the concept of hierarchical link-sharing and each class in the hierarchy is bound with a token bucket, which can shape the traffic of this class. The analysis and simulation results presented in the paper show that through the novel way of weighted fair token sharing, this proposed algorithm guarantees basic bandwidth service for each class and enables weighted fair sharing of excess bandwidth, with which home computers connected to the network share the Internet service evenly.
Serum alpha 2-HS-glycoprotein is an inhibitor of the human insulin receptor at the tyrosine kinase level. (1993)

The insulin-dependent tyrosine kinase activity (TKA) of the insulin receptor (IR) plays an essential role in insulin signaling. Thus, dysregulation of IR-TKA might be an important element in the states of insulin resistance. A phosphorylated rat hepatic glycoprotein (pp63) acting as an inhibitor of IR-TK has been described. In search of the human homolog of pp63, we isolated a cDNA clone from a human liver lambda gt11 cDNA library. DNA sequence analysis reveals identity with the mRNA product of a human gene AHSG encoding a serum protein, alpha 2-Heremans Scmid-glycoprotein (alpha 2HSG), with heretofore unknown physiological function. Northern blot analysis demonstrates a 1.8-kilobase mRNA in human liver and HepG2 hepatoma cells. alpha 2HSG, purified from human serum, specifically inhibits insulin-stimulated IR autophosphorylation in vitro and in vivo as well as exogenous substrate tyrosine phosphorylation. alpha 2HSG also inhibits both insulin-induced tyrosine phosphorylation of IRS-1 and the association of IRS-1 with the p85 subunit of phosphatidylinositol-3 kinase in H-35 hepatoma cells. alpha 2HSG inhibits insulin-dependent mitogenesis, but does not affect insulin-stimulated induction of the metabolic enzyme tyrosine aminotransferase. alpha 2HSG does not compete with insulin for binding to IR. Finally, the action of alpha 2HSG is specific toward the IR-TK; its effect does not extend to insulin-like growth factor-I-stimulated TKA. Our results allow us to assign a biochemical function for human alpha 2HSG, namely regulation of insulin action at the IR-TK level.
Randomized, Controlled Study of Telcagepant in Patients With Migraine and Coronary Artery Disease (2012)

The study was underpowered due to enrollment difficulties and did not demonstrate a significant efficacy difference between telcagepant and placebo for the treatment of a migraine attack in patients with stable coronary artery disease. Telcagepant was generally well tolerated for acute intermittent migraine treatment in these patients.
Widespread tissue distribution of human chymase. (1994)

Our studies have revealed heterogeneous and widespread tissue distribution of human chymase throughout the human body and indicate that chymase probably has a significant influence not only in the heart but also in other tissues.
Discrimination Between Painful and Painless Diabetic Neuropathy Based on Testing of Large Somatic Nerve and Sympathetic Nerve Function (1992)

The syndromes of painful diabetic neuropathy and painless foot ulceration are distinct clinical entities. To investigate whether there is a pattern of nerve fibre involvement that could clearly discriminate between them, we have studied three groups of diabetic patients, 19 with painful neuropathy, 14 with painless foot ulceration, and 19 with no clinical neuropathy. Large somatic nerve fibre function was assessed by nerve conduction studies and vibration thresholds, small somatic nerve function by cooling and warming thresholds, the parasympathetic system by heart-rate dependent cardiac autonomic reflexes, and the sympathetic system by postural drop in blood pressure and plasma noradrenaline (supine and erect). Normal ranges were obtained from 25 age-matched healthy subjects. Painful neuropathy was characterized by uniform dysfunction of small somatic fibres and preserved sympathetic nerve activity (plasma noradrenaline) with a wide range of large somatic fibre and autonomic reflex abnormalities. By contrast, in painless foot ulceration there was universal severe dysfunction of all nerve fibre populations. Discriminant analysis identified peroneal motor conduction velocity as the best single variable for distinguishing between painful and painless neuropathy (81% of cases). A combination of peroneal motor conduction velocity with vibration threshold and plasma noradrenaline discriminated completely between the two clinical syndromes. These findings suggest that the key differences between painful and painless diabetic neuropathy are in large somatic and sympathetic fibre function.
Variation and Influence of the Local Structure around Ti in NaAlH4 Doped with a Ti-Based Precursor (2007)

The kinetics and hydrogen storage capacity of Ti-doped sodium alanate prepared by ball milling of an AlxTi(1-x) nanocomposite as Ti-containing starting material with NaH remain comparably stable upon cycling under hydrogen. The reaction rate of this material is comparable to that of TiCl3-doped samples. Extended X-ray absorption fine structure (EXAFS) analysis revealed that forming an AlxTi(1-x) nanocomposite by the reduction of TiCl4 by Al and subsequent annealing stabilizes the short-range order around Ti. The presence of stable Al−Ti phases at the beginning of the reaction prevents the subsequent formation of a Ti−Al cluster upon cycling under hydrogen, which is found in the case of doping with TiCl3. When the atomic-scale behavior of this new material is compared with that of the TiCl3- or Ti colloid-doped sodium alanates, it is found that the chemical state of Ti as well as its local structure seem to be relevant for the stability of the storage capacity and desorption/absorption reaction rate upon cycling under hydrogen.
210-GHz InAlN/GaN HEMTs With Dielectric-Free Passivation (2011)

Lattice-matched depletion-mode InAlN/AlN/GaN high-electron mobility transistors (HEMTs) on a SiC substrate were fabricated, for the first time, with a dielectric-free passivation (DFP) process in which the device access region was treated by O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> /Ar plasma. Similar to dielectric passivation using SiN and Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> , the plasma treatment can effectively shorten the gate-length extension. As a result, the current gain cutoff frequency fT of a 60-nm rectangular-gate HEMT increased from 125 to 210 GHz after the plasma DFP; this RF performance is among the highest reported fT for GaN-based HEMTs. The device showed a dc drain current density of 2.1 A/mm and a peak extrinsic transconductance of 487 mS/mm after DFP. The Lg-fTproduct of 12.6 GHz ·μm is among the highest reported for a gate-physical-length-to-barrier-thickness aspect ratio of 5.6. Small gate lag and drain lag are observed in pulsed I-V measurements with a 300-ns pulsewidth.
Individual embryonic fibroblasts express multiple beta chains in association with the alpha v integrin subunit. Loss of beta 3 expression with cell confluence. (1991)

The alpha chain of the vitronectin receptor, alpha v, has been found in association with the integrin subunits beta 1, beta 3, or beta 5 on different cell types. We show here that cultured embryonic fibroblasts simultaneously display alpha v beta 3, alpha v beta 1, and alpha v in association with two other beta subunits, one of which is probably beta 5. Polymerase chain reaction analysis of single cells isolated by micromanipulation identified mRNA for alpha v, beta 1, beta 3, and beta 5 in six of eight clones. Immunoprecipitation of iodinated cell surface proteins with a monoclonal antibody to alpha v indicated that the relative proportions of the different beta chains in association with alpha v varied, particularly between two different cell lines. The cytokines platelet-derived growth factor, transforming growth factor beta 1, and tumor necrosis factor alpha did not appear to alter this ratio although tumor necrosis factor alpha increased the surface expression of the alpha v-associated integrins; but overnight culture in basic fibroblast growth factor caused a lower expression of alpha v beta 1 and alpha v beta 5 with no reduction in alpha v beta 3 expression. When the cell cultures were grown to complete confluence, surface expression of beta 3 was abolished, and the expression of an unknown beta chain (beta u) became more prominent. This effect was not overcome by culturing confluent cells with basic fibroblast growth factor. Affinity column chromatography showed that alpha v beta 5 bound to vitronectin but alpha v beta 1 did not, whereas alpha v beta 1 but not alpha v beta 5 bound to fibronectin. These results suggest that, on individual cells, the beta subunits found in association with alpha v may vary according to the proliferative capacity of the cell and that the promiscuous beta 3 subunit is progressively replaced by beta subunits of individual ligand specificity.
Evaluation of the Effect of Diabetes on Rheumatoid Arthritis–related Outcomes in an Electronic Health Record–based Rheumatology Registry (2020)

Patients with RA with concomitant DM had greater worsening, or less improvement, in their functional status, suggesting additional interventions may be needed for RA patients with DM to optimize treatment and management of other comorbidities.
Si through-hole interconnections filled with Au-Sn solder by molten metal suction method (2003)

This paper deals with a fabrication method of conductive through-holes in a silicon substrate, which can be applied for micro electro-mechanical system (MEMS) devices or high-density packaging. The through-holes are formed by deep reactive ion etching (DRIE) and filled with Au-Sn solder by molten metal suction method (MMSM). The MMSM we have proposed is capable of filling high aspect ratio thorough-holes with conductive metal. We could make more than 18,000 conductive through-holes, 30 /spl mu/m in diameter and 300 /spl mu/m in depth, in a 4 inches sized silicon (Si) wafer. We report the principle of the filling, the fabrication processes and the structure of the through-hole interconnections.
What ails our health libraries? : Problems and approaches in the E-book Era (2012)

It is obvious that health libraries today could be healthier. But what diagnosis can we offer - what precisely is the problem? Is it competition from the Internet? Budget cuts in healthcare? Perhaps lack of support for libraries in the upper levels of management?