gebhart/patrepeval huggingface dataset:
Making Rats Rise to Erect Bipedal Stance for Feeding Partially Prevented Orchidectomy-Induced Bone Loss and Added Bone to Intact Rats (2000)

The objectives of this study were to investigate the different effects on muscle mass and cancellous (proximal tibial metaphysis [PTM]) and cortical (tibial shaft [TX]) bone mass of sham-operated and orchidectomized (ORX) male rats by making rats rise to erect bipedal stance for feeding. Specially designed raised cages (RC) were used so that the rats had to rise to erect bipedal stance to eat and drink for 12 weeks. Dual-energy X-ray absorptiometry (DEXA) and peripheral quantitative computerized tomography (pQCT) were used to estimate the lean leg mass and bone mineral. Static and dynamic histomorphometry were performed on the triple-labeled undecalcified sections. We found that making the intact rats rise to erect bipedal stance for feeding increased muscle mass, cortical bone volume, and periosteal bone formation. Orchidectomy increased net losses of bone next to the marrow by increasing bone turnover. Making the ORX rats rise to erect bipedal stance increased muscle mass, partially prevented cancellous bone loss in the PTM, and prevented net cortical bone loss in TX induced by ORX by depressing cancellous and endocortical high bone turnover and stimulating periosteal bone formation. The bone-anabolic effects were achieved mainly in the first 4 weeks in the PTM and by 8 weeks in the TX. These findings suggested that making the rats rise to erect bipedal stance for feeding helped to increase muscle mass and cortical bone mass in the tibias of intact rats, increase muscle mass, and partially prevented cancellous and net cortical bone loss in ORX rats.
Serum osteoprotegerin concentration is associated with carotid atherosclerotic plaque in patients with rheumatoid arthritis (2013)

Objective Osteoprotegerin (OPG), a regulator of bone resorption, is involved in the pathogenesis of rheumatoid arthritis (RA) and atherosclerosis. OPG is elevated in patients with coronary artery disease, and high OPG levels are associated with cardiac disease severity and mortality in the general population. The purpose of this study was to investigate the relationship of serum OPG levels, traditional coronary risk factors, and RA-related factors to carotid atherosclerosis in RA patients. Methods Ninety-one RA patients were studied (85 % women, age 60 ± 10 years). Serum OPG levels were measured by an enzyme-linked immunosorbent assay. The prevalence of carotid plaque was assessed by ultrasonographic imaging in all patients. The relationship between various clinical characteristics, OPG, and carotid plaque was examined. Results Serum OPG levels were significantly higher in patients with carotid plaque than in those without plaque (median level 1,397 vs. 887 pg/mL, respectively; P = 0.006). There were no significant differences between RA patients with and without carotid plaque with respect to sex, duration of RA, blood pressure, body mass index, smoking, low-density lipoprotein cholesterol, Disease Activity Score-28, van der Heijde-modified Sharp score, and prednisolone dose. After adjusting for age, sex, and C-reactive protein, elevated levels of OPG were still associated with a higher prevalence of carotid plaque in patients with RA (P = 0.038). Conclusion RA patients suffer from accelerated atherosclerosis and also have increased levels of OPG. The serum OPG level is independently associated with carotid plaque.
End-to-End Trainable Multi-Instance Pose Estimation with Transformers (2021)

We propose an end-to-end trainable approach for multi-instance pose estimation, called POET (POse Estimation Transformer). Combining a convolutional neural network with a transformer encoder-decoder architecture, we formulate multiinstance pose estimation from images as a direct set prediction problem. Our model is able to directly regress the pose of all individuals, utilizing a bipartite matching scheme. POET is trained using a novel set-based global loss that consists of a keypoint loss, a visibility loss and a class loss. POET reasons about the relations between multiple detected individuals and the full image context to directly predict their poses in parallel. We show that POET achieves high accuracy on the COCO keypoint detection task while having less parameters and higher inference speed than other bottom-up and top-down approaches. Moreover, we show successful transfer learning when applying POET to animal pose estimation. To the best of our knowledge, this model is the first end-to-end trainable multi-instance pose estimation method and we hope it will serve as a simple and promising alternative.
A regulator of ubiquitin-proteasome activity, 2-hexyldecanol, suppresses melanin synthesis and the appearance of facial hyperpigmented spots (2013)

These data indicate that regulation of proteasome activity is a viable target for control of melanin production, that 2-hexyldecanol upregulates proteasomal activity in melanocytes, and that topical 2-hexyldecanol reduces the appearance of hyperpigmentation.
The Indiana Company 1768-1798: A Study in Eighteenth Century Frontier Land Speculation and Business Venture (1942)

Journal Article The Indiana Company 1768–1798: A Study in Eighteenth Century Frontier Land Speculation and Business Venture. By George E. Lewis. (Glendale, Calif.: The Arthur H. Clark Co., 1941. 358 pp. Illustrations, maps, and bibliography. $6.00.) Get access C. H. Ambler C. H. Ambler West Virginia University Search for other works by this author on: Oxford Academic Google Scholar Journal of American History, Volume 29, Issue 2, September 1942, Pages 255–256, https://doi.org/10.2307/1896285 Published: 01 September 1942
Detailed Response of Some Rock Targets to Jets from Lined-Cavity Shaped Charges (1964)

Abstract The U. S. Naval Ordnance Test Station has a continuing program of applied research in rock and earth dynamics. One aspect of this program has been the investigation of rock masses subjected to jet attack from lined-cavity shaped charges. The detailed testing of rock response has been carried out in air using dry bulk targets of sufficient size to preclude gross target fracturing during penetration. Overcoring methods have then been used to remove the penetration area to permit section in g and studying the hole walls. During these tests two distinct modes of penetration wall response were observed. One mode is well illustrated by coarse-grained silicate rocks which yield penetrations with severe adjacent grain damage plus significant compaction and stored energy, which is slowly released by failure of the hole walls. The second mode is illustrated by limestone, which gives virtually no megascopic damage adjacent to the hole and which is stable following penetration. Under proper conditions, however, the limestone samples consistently yield liner-metal and liner-metal-oxide filled fractures adjacent to the penetration. Tests were also performed which permitted evaluation of the effect of gross target fracturing during penetration, and evaluation of the concept of rock density as a criterion of penetration depth. Introduction The mechanisms of jet formation by various configurations of lined-cavity shaped charges and of penetration in metallic targets have been extensively reported in the technical literature. Jet penetration into rock and earth materials has been investigated in conjunction with mining uses and a considerable body of technical literature established on the petroleum industry applications of shaped-charge phenomena. Examination of these many publications reveals that the details of the response of rock targets to the jet penetration process are not well known. The studies reported in this paper were performed to establish the detailed response of rock targets in air to jets from lined-cavity shaped charges and, as such, do not necessarily represent down-hole, well phenomena. The rocks selected for testing are representative of broad groupings of geologic materials that occur in bulk on the earth's surface, but only the general materials applicable to the petroleum industry are discussed. Although the igneous rocks, per se, are of minor interest to petroleum engineers, these rocks are occasionally important reservoir rocks. Furthermore, the igneous rocks, despite their limited occurrence as reservoir rocks, offer a wealth of pertinent data on general rock behavior. The behavior of igneous rocks is also believed to be representative of the behavior of dense, hard, low porosity silicate rocks in general. Quartzites, strong sandstones and many metasediments are believed to belong in this grouping of materials.A set of standard definitions of penetration effects must be established in order to permit a useful discussion of jet penetration phenomena. JPT P. 41^
M2 forming - a process for aromatization of light hydrocarbons (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTM2 forming - a process for aromatization of light hydrocarbonsNai Y. Chen and Tsoung Y. YanCite this: Ind. Eng. Chem. Process Des. Dev. 1986, 25, 1, 151–155Publication Date (Print):January 1, 1986Publication History Published online1 May 2002Published inissue 1 January 1986https://doi.org/10.1021/i200032a023RIGHTS & PERMISSIONSArticle Views916Altmetric-Citations151LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (585 KB) Get e-Alerts
Aqueous solution‐processed NiOx anode buffer layers applicable for polymer solar cells (2016)

ABSTRACT A green and facile method has been developed for the room temperature and aqueous solution preparation of NiO x film as anode buffer layers for polymer solar cells (PSCs). The NiO x buffer layer is prepared simply by spin‐coating nickel acetylacetonate precursor‐based aqueous solution onto ITO substrate at room temperature in air. UV‐ozone post‐treatment promotes the formation of dipolar NiOOH species on the film surface, resulting in the anode buffer layer with suitable work function. PSCs have been fabricated with the device structure of ITO/NiO x /photoactive layer/PFN/Al. The power conversion efficiencies of the PSCs based on PTB7:PC 71 BM blends (8.43%) and P3HT:PC 71 BM blends (3.04%) with NiO x anode buffer layer are comparable to those with the commonly used PEDOT:PSS anode buffer layer. In addition, the devices made with NiO x buffer layer exhibit much better air stability than those with PEDOT:PSS. These results indicate that the water solution processed NiO x film at room temperature in air is a promising anode buffer layer for efficient and stable PSCs. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017 , 55 , 747–753
FULSOME: a fuzzy logic modeling tool for software metricians (2003)

There has been a growing body of literature suggesting that some of the problems faced by software development project managers can be at least partially overcome by using fuzzy logic techniques. However, one issue that has been generally overlooked in this recommendation is the means by which these "software metricians" can collect data for, develop, and interpret fuzzy logic models in practice. We describe a freely available system that has been built with this in mind called FULSOME (FUzzy Logic for SOftware MEtrics). While there are many tools available for developing fuzzy models, it is suggested that before there will be real adoption of such techniques by project managers there will need to be suitable tools that support their particular workflows and that use appropriate terminology. Another requirement will be the development of some standard procedures and definitions for such models. Issues involved with membership function elicitation and extraction are also discussed as a first step towards this second goal.
Identification of four novel variants that influence central corneal thickness in multi-ethnic Asian populations (2012)

10.1093/hmg/dds269
High-Throughput Phenotypic Screening of Human Astrocytes to Identify Compounds That Protect Against Oxidative Stress (2016)

Astrocytes play a key role in neurological diseases. Drug discovery efforts that target astrocytes can identify novel therapeutics. Human astrocytes are difficult to obtain and thus are challenging to use for high-throughput screening, which requires large numbers of cells. Using human embryonic stem cell-derived astrocytes and an optimized astrocyte differentiation protocol, it was possible to screen approximately 4,100 compounds in titration to identify 22 that are cytoprotective of astrocytes. This study is the largest-scale high-throughput screen conducted using human astrocytes, with a total of 17,536 data points collected in the primary screen. The results demonstrate the relevancy and utility of using astrocytes differentiated from human stem cells as a disease model for drug discovery and development.
Neutrophil CEACAM1 determines susceptibility to NETosis by regulating the S1PR2/S1PR3 axis in liver transplantation (2023)

Neutrophils, the largest innate immune cell population in humans, are the primary proinflammatory sentinel in the ischemia-reperfusion injury (IRI) mechanism in orthotopic liver transplantation (OLT). Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1, CC1, or CD66a) is essential in neutrophil activation and serves as a checkpoint regulator of innate immune-driven IRI cascade in OLT. Although CC1 alternative splicing generates two functionally distinct short and long cytoplasmic isoforms, their role in neutrophil activation remains unknown. Here, we undertook molecular and functional studies to interrogate the significance of neutrophil CC1 signaling in mouse and human OLT recipients. In the experimental arm, we employed a mouse OLT model to document that ablation of recipient-derived neutrophil CC1-long (CC1-L) isotype aggravated hepatic IRI by promoting neutrophil extracellular traps (NETs). Notably, by regulating the S1P-S1PR2/S1PR3 axis, neutrophil CC1-L determined susceptibility to NET formation via autophagy signaling. In the clinical arm, liver grafts from 55 transplant patients selectively enriched for neutrophil CC1-L showed relative resistance to ischemia-reperfusion (IR) stress/tissue damage, improved hepatocellular function, and clinical outcomes. In conclusion, despite neutrophils being considered a principal villain in peritransplant tissue injury, their CC1-L isoform may serve as a regulator of IR stress resistance/NETosis in human and mouse OLT recipients.
A study on the resugence of cotton bollworm induced by chemical insecticides (2001)

The number of cotton bollworm(CBW) and it^s natural enemies were investigated in three different kinds of cotton fields with over-used pesticides or with less frequently used pesticides or rarely used pesticides. The history of applying chemical pesticides to control the CBW in Hena cotton region was analyzed by combining with the investigation data. It is found that the chemical pesticides have double effects, which reduce the population density temporarily and lead to the resurgence of CBW, consequently, increase the insecticide resistance markedly. The resurgence accompanied with the applying of chemical pesticides in the sign of increase of insecticide resistance. Under suitable host plants and climate condition, CBW can have outbreak after developing a high level resistance to the main kinds of chemical insecticide had this research result is useful for the long and medium-term forecast of CBW and the proper use of chemical pesticides.
Solution and Solid‐Phase Chemoselective Synthesis of (1‐6)‐Amino(methoxy) Di‐ and Trisaccharide Analogues. (2002)

Abstract For Abstract see ChemInform Abstract in Full Text.
A multitone pseudocascade, filtered-X LMS adaptive notch filter (1993)

A filtered-X version of the LMS notch filter (FXLMS) is useful for narrowband applications where the cancelling signal cannot be directly applied to the primary signal. However, cancellation path delay limits the bandwidth performance of the filter. A cascade of FXLMS notch filters using multiple reference tones is examined for alleviating this problem. An analysis of a single-stage notch filter characterizes the response by the cancellation bandwidth and out-of-band overshoot. The results are used to synthesize a multistage cascade with offset reference tones. A pseudocascade configuration that only requires one entry point to the primary disturbance plant is also formulated. Numerical results for a three-stage FXLMS notch filter are given. Results are also presented for the cascade transient response, overshoot compensation, and extension to the multichannel case.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Selected translocation of plasmid genes: frequency and regional specificity of translocation of the Tn3 element (1977)

A procedure is described that selects for the insertion of transposable antibiotic resistance elements in a variety of recipient replicons. The selected translocation procedure, which employs a plasmid having a temperature-sensitive defect in replication as a donor of transposable genetic elements, was used to investigate certain characteristics of the translocation process. Our results indicate that translocation of the Tn3 element from plasmid to plasmid occurs at a 10(3)- to 10(4)-times-higher frequency than from plasmid to chromosome. In both cases, continued accumulation of Tn3 on recipient genomes is prevented by development of an apparent equilibrium when only a small fraction of molecules in the recipient population contain Tn3. An alternative method for estimation of translocation frequency has shown that the translocation process is temperature sensitive and that its frequency is unaffected by the presence of host recA mutation. Insertions of Tn3 onto the 65 X 10(6)-dalton R6-5 plasmid in Escherichia coli are clustered on EcoRI fragments 3 (8 of 23 insertions) and 9 (7 of 23 insertions), which contain 12 and 5%, respectively, of the R6-5 genome. The occurrence of multiple insertions of Tn3 within EcoRI fragment 9, which contains the IS1 element and a terminus of the Tn4 element, is consistent with earlier evidence indicating that terminal deoxyribonucleic acid sequences of already present transposable elements may provide recognition sequences for subsequent illegitimate recombinational events.
Habitual Tea Consumption and Risk of Osteoporosis: A Prospective Study in the Women's Health Initiative Observational Cohort (2003)

The purpose of this study was to prospectively investigate associations of habitual drinking of regular tea with bone mineral density and fracture risk. Study participants were a multiethnic postmenopausal cohort (n = 91,465) from the nationwide Women's Health Initiative Observational Study. These women were recruited in the United States and aged 50-79 years at the time of enrollment (1994-1998). The average follow-up time was 4.1 years. Habitual consumption of regular tea was assessed with a structured questionnaire at baseline. Clinical fractures during the follow-up were reported in questionnaires, and hip fractures were further confirmed by reviewing medical records. Bone mineral density measurements were conducted among a subgroup of women (n = 4,979) at three Women's Health Initiative bone mineral density centers using dual-energy x-ray absorptiometry. Multivariate analyses suggested a positive trend of increased total body bone mineral density with tea drinking (p < 0.05). However, results from the Cox proportional hazard models did not show any significant association between tea drinking and the risk of fractures at the hip and forearm/wrist. In conclusion, the results from this study indicate that the effect of habitual tea drinking on bone density is small and does not significantly alter the risk of fractures among the US postmenopausal population.
Functionally Graded Boron Carbide (2010)

Fabrication techniques were developed for producing graded porosity B4C, and for producing aluminum-B4C and epoxy-B4C fuctionally graded materials. The key fabrication aspect was obtaining the graded porosity B4C. The feasibility of producing graded porosity B4C using a grading of carbon densification aid produced from a gradient of furfuryl alcohol carbon precursor was demonstrated. This approach is quite promising, but it was not optimized in the present investigation. Graded porosity B4C materials were produced by a layering approach using different size distributions of B4C powders in the green state, and then densifLing the layered assembly by hot pressing at 1900°C. The hardness of uninfiltrated graded B4C, aluminum infiltrated B4C, and epoxy infiltrated B4C was observed to be similar.
Denaturing HPLC-Based Assay for Molecular Screening of Nondeletional Mutations Causing α-Thalassemias (2004)

restricted erythropoiesis.
ChemInform Abstract: NEW FRIEDEL‐CRAFTS CHEMISTRY. XXXI. ALKYLATIONS AND COMPETING REARRANGEMENTS IN THE ALUMINUM CHLORIDE CATALYZED REACTIONS OF SECONDARY ALKYL CHLORIDES WITH ARENES (1976)

Abstract Benzol (Ia) bzw. p‐Xylol (Ib) werden mit den sekundären Alkylchloriden (IIa), (IIb) bzw. (IIIa), (IIIb) umgesetzt und die über Äquilibrierungsreaktionen gebildeten Alkylierungsprodukte identifiziert.
ChemInform Abstract: Synthesis and Absolute Configuration of Stellettadine A, a Bisguanidinium Alkaloid Isolated from a Marine Sponge Stelletta sp. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Erratum: “Effect of hydrothermal condition on the formation of multi-component oxides of Ni-based metallic glass under high temperature water near the critical point” [AIP Advances 5, 077132 (2015)] (2015)

In the original manuscript, M. H. Lee’s affiliation number was incorrectly listed as 1. M. H. Lee’s correct affiliation number is 2 (Rare Metals R&D Group, Korea Institute of Industrial Technology, Incheon 406-840, South Korea). Furthermore, this change affects no other part of the paper.
Weighted Fair Precoding Based on Traffic Demands for Multibeam Satellite Systems (2019)

In this paper, a linear precoding scheme is proposed to maximize the total throughput of a broadband geostationary earth orbit (GEO) satellite system based on traffic demands. The weighted max-min fair (WMMF) problem under the per-antenna power constraints and the traffic demands constraints is investigated to achieve this purpose. Semidefinite relaxation (SDR) approach and bisection search method are jointly adopted to solve the corresponding related problem, and then Gaussian randomization and a power control problem are proposed to get a suboptimal solution of the WMMF problem. Different traffic demands scenarios and weighted values selection schemes are considered to analyze the impact of them on the precoding design. Simulation results demonstrate that the total performance of the proposed scheme has been improved significantly over the traditional schemes and is better than the rate balance scheme.