gebhart/patrepeval huggingface dataset:
Imprinting by DNA methylation: from transgenes to endogenous gene sequences (1990)

A number of transgenes in the mouse show variation in methylation and expression phenotypes dependent on parental transmission. It appears that there exist at least two types of transgene imprinting; one is retained on an essentially homozygous background, while the other requires heterozygosity at some modifying loci in the genome and is observed as differences in phenotype in reciprocal crosses. For this type of imprinting to occur, the parental origin of the modifier locus itself is important, and parental asymmetry may involve specific interactions between egg cytoplasm and the chromosomes. Based on the identification of 'methylation polymorphism' in the mouse genome, we also show that endogenous gene sequences can undergo imprinting by DNA methylation.
ChemInform Abstract: NONSTEROIDAL ANTIINFLAMMATORY AGENTS. 1. A NOVEL SYNTHESIS OF 1‐METHYL‐5‐P‐TOLYLPYRROLE‐2‐ACETIC ACID (TOLMETIN) (1983)

Abstract N‐Methyl‐pyrrol (I) reagiert mit dem p‐Toluoylsäure‐morpholid (II) in Gegenwart von Phosphoroxychlorid zum Z‐Acyl‐Derivat (IIIa), dessen Friedel‐Crafts‐Acylierung (IIIb) Iiefert.
Isolation and Distribution of a Novel Iron-Oxidizing Crenarchaeon from Acidic Geothermal Springs in Yellowstone National Park (2007)

Novel thermophilic crenarchaea have been observed in Fe(III) oxide microbial mats of Yellowstone National Park (YNP); however, no definitive work has identified specific microorganisms responsible for the oxidation of Fe(II). The objectives of the current study were to isolate and characterize an Fe(II)-oxidizing member of the Sulfolobales observed in previous 16S rRNA gene surveys and to determine the abundance and distribution of close relatives of this organism in acidic geothermal springs containing high concentrations of dissolved Fe(II). Here we report the isolation and characterization of the novel, Fe(II)-oxidizing, thermophilic, acidophilic organism Metallosphaera sp. strain MK1 obtained from a well-characterized acid-sulfate-chloride geothermal spring in Norris Geyser Basin, YNP. Full-length 16S rRNA gene sequence analysis revealed that strain MK1 exhibits only 94.9 to 96.1% sequence similarity to other known Metallosphaera spp. and less than 89.1% similarity to known Sulfolobus spp. Strain MK1 is a facultative chemolithoautotroph with an optimum pH range of 2.0 to 3.0 and an optimum temperature range of 65 to 75 degrees C. Strain MK1 grows optimally on pyrite or Fe(II) sorbed onto ferrihydrite, exhibiting doubling times between 10 and 11 h under aerobic conditions (65 degrees C). The distribution and relative abundance of MK1-like 16S rRNA gene sequences in 14 acidic geothermal springs containing Fe(III) oxide microbial mats were evaluated. Highly related MK1-like 16S rRNA gene sequences (>99% sequence similarity) were consistently observed in Fe(III) oxide mats at temperatures ranging from 55 to 80 degrees C. Quantitative PCR using Metallosphaera-specific primers confirmed that organisms highly similar to strain MK1 comprised up to 40% of the total archaeal community at selected sites. The broad distribution of highly related MK1-like 16S rRNA gene sequences in acidic Fe(III) oxide microbial mats is consistent with the observed characteristics and growth optima of Metallosphaera-like strain MK1 and emphasizes the importance of this newly described taxon in Fe(II) chemolithotrophy in acidic high-temperature environments of YNP.
Truth-function evaluation using the Polish notation (1952)

http://deepblue.lib.umich.edu/bitstream/2027.42/3977/5/bab9690.0001.001.pdf
Macro-and Micro-Structure of Continuously Cast Slab (1974)

Macro-and micro-structure of continuously cast slab are studied. Macro-structure is mainly dependent on casting temperature. Because of its high solidification rate, macro-segregation hardly takes place. Macro-structure is composed of columnar dendrite, brached dendrite and equiaxed crystal. Micro-segregation takes place not only between dendrite stem and interdendrite, but also inside and outside of equi-axed crystal. Micro-segregation is causative of center line segregation of continuously cast slab when solute enriched melt is squeezed from interdendrite into cavity which is formed by solidification shrinkage or bulging of solidified shell by ferrostatic pressure.
High Temperature Permanent Magnet Machine Actuators for Aerospace Applications (2012)

The paper presents technologies for developing efficient high temperature permanent magnet machines implemented in aerospace drive applications. Selection criteria and experimental investigation of the permanent magnet material is undertaken and design considerations enabling to meet the specifications set are described. The proposed control algorithm for an appropriate PWM inverter is introduced.
Syntheses of Tetrahydrolipstatin and Absolute Configuration of Tetrahydrolipstatin and Lipstatin (1987)

Abstract Lipstatin ( 1 ), a natural product, and tetrahydrolipstatin ( 2 ) are pancreatic lipase inhibitors. Non‐stereoselective and partially stereoselective syntheses of 2 are used to establish the absolute configuration of tetrahydrolipstatin and lipstatin.
Establishment of an efficient in vitro culture and particle bombardment-mediated transformation systems in Miscanthus sinensis Anderss., a potential bioenergy crop (2011)

Plants belonging to the genus Miscanthus are considered promising bioenergy crops. Here, we report the establishment of tissue culture system through particle bombardment- mediated transformation in Miscanthus sinensis Anderss. Callus was induced efficiently from mature seeds in a medium containing a combination of a relatively high level of 2,4-dichlorophenoxyacetic acid (5mgL 1) and a relatively low level of 6-benzyladenine (BA) (0.01mgL 1). Callus induction potential of 18 accessions of M. sinensis, which were collected from various sites in Japan, was compared. Significant correlation was detected between compact (embryogenic) callus induction frequency and average annual air temperature in collection sites. An accession from Tanegashima Island showed the highest production of compact callus. We found that a higher level of BA causes callus browning; the 2mg L 1 BA is the optimal concentration for regeneration. Both compact and friable calli were suitable for particle bombardment transformation. Through selection under the presence of 50mgL 1 hygromycin for 3 weeks and further selection under the presence of 150mgL 1 for 1 month, hygromycin-resistant calli survived, of which 72.2% had been entirely transformed. Plants were regenerated from calli in the presence of hygromycin; transcripts of the hpt and gfp genes, which were cobombarded to the calli, were detected in the regenerated plants. This is the first report on the establishment of the in vitro culture of M. sinensis using mature seeds, the variation of callus formation among accessions collected from various sites in Japan, and particle bombardment-mediated transformation in the genus Miscanthus.
Improved Postoperative Pain Control using Thoracic Paravertebral Block for Breast Operations (2009)

Thoracic paravertebral block (PVB) in breast surgery can provide regional anesthesia during and after surgery with the potential advantage of decreasing postoperative pain. We report our institutional experience with PVB over the initial 8 months of use. All patients undergoing breast operations at the ambulatory care building from September 09, 2005 to June 28, 2005 were reviewed. Comparison was performed between patients receiving PVB and those who did not. Pain scores were assessed immediately, 4 hours, 8 hours and the morning after surgery. 178 patients received PVB and 135 patients did not. Patients were subdivided into three groups: Group A-segmental mastectomy only (n = 89), Group B-segmental mastectomy and sentinel node surgery (n = 111) and Group C-more extensive breast surgery (n = 113). Immediately after surgery there was a statistically significant difference in the number of patients reporting pain between PVB patients and those without PVB. At all time points up until the morning after surgery PVB patients were significantly less likely to report pain than controls. Patients in Group C who received PVB were significantly less likely to require overnight stay. The average immediate pain scores were significantly lower in PVB patients than controls in both Group B and Group C and approached significance in Group A. PVB in breast surgical patients provided improved postoperative pain control. Pain relief was improved immediately postoperatively and this effect continued to the next day after surgery. PVB significantly decreased the proportion of patients that required overnight hospitalization after major breast operations and therefore may decrease cost associated with breast surgery.
Design and measurement of W-band offset stepped parabolic reflector antennas for airport surface foreign object debris detection radar systems (2014)

Debris on the airport surface may cause severe damage to aircraft. To detect these obstacles, foreign object debris (FOD) detection systems have been developed recently. By utilizing high-sensibility and weather robustness characteristics, the millimeter-wave radar is an essential sensor device for these systems. This paper discusses an offset parabolic reflector antenna for airport surface FOD detection radar systems. Firstly, the overview of the FOD detection radar systems, which employs a band of between 92 GHz and 100 GHz, is shown. For the azimuth beam scanning antenna, the antenna is required to achieve both a narrow azimuth beamwidth and a wide elevation beamwidth. Secondly, the stepped parabolic reflector is newly designed to obtain an 8 degree elevation -20 dB down power beamwidth. Finally, the designed reflector is fabricated based on chemical wood materials. The measured result shows the 38 dBi gain and the 8.4 degree beamwidth for the elevation plane.
Controlled Growth of Monodisperse Self-Supported Superparamagnetic Nanostructures of Spherical and Rod-Like CoFe2O4 Nanocrystals (2009)

Novel shape- and structural-controlled superparamagnetic nanostructures composed of self-supported spherical and rod-like CoFe(2)O(4) colloidal nanocrystals have been prepared by thermolysis of a stoichiometric Co(2+)Fe(2)(3+)-oleate complex in organic solution with periodic injection of hexane for controlling the nucleation, assembly, and growth of the nuclei.
Observation of confinement-induced resonances in a 3D lattice (2022)

We report on the observation of confinement-induced resonances for strong three-dimensional (3D) confinement in a lattice potential. Starting from a Mott-insulator state with predominantly single-site occupancy, we detect loss and heating features at specific values for the confinement length and the 3D scattering length. Two independent models, based on the coupling between the center-of-mass and the relative motion of the particles as mediated by the lattice, predict the resonance positions to a good approximation, suggesting a universal behavior. Our results extend confinement-induced resonances to any dimensionality and open up an alternative method for interaction tuning and controlled molecule formation under strong 3D confinement.
Allogeneic hematopoietic cell transplantation, the microbiome, and graft-versus-host disease (2023)

Many patients with hematological malignancies, such as acute myeloid leukemia, receive an allogeneic hematopoietic cell transplantation (HCT) to cure their underlying condition. Allogeneic HCT recipients are exposed to various elements during the pre-, peri- and post-transplant period that can disrupt intestinal microbiota, including chemo- and radiotherapy, antibiotics, and dietary changes. The dysbiotic post-HCT microbiome is characterized by low fecal microbial diversity, loss of anaerobic commensals, and intestinal domination, particularly by <i>Enterococcus</i> species, and is associated with poor transplant outcomes. Graft-versus-host disease (GvHD) is a frequent complication of allogeneic HCT caused by immunologic disparity between donor and host cells and results in tissue damage and inflammation. Microbiota injury is particularly pronounced in allogeneic HCT recipients who go on to develop GvHD. At present, manipulation of the microbiome for example, via dietary interventions, antibiotic stewardship, prebiotics, probiotics, or fecal microbiota transplantation, is widely being explored to prevent or treat gastrointestinal GvHD. This review discusses current insights into the role of the microbiome in GvHD pathogenesis and summarizes interventions to prevent and treat microbiota injury.
Caspase-3 suppresses diethylnitrosamine-induced hepatocyte death, compensatory proliferation and hepatocarcinogenesis through inhibiting p38 activation (2018)

It is critical to understand the molecular mechanisms of hepatocarcinogenesis in order to prevent or treat hepatocellular carcinoma (HCC). The development of HCC is commonly associated with hepatocyte death and compensatory proliferation. However, the role of Caspase-3, a key apoptotic executor, in hepatocarcinogenesis is unknown. In this study, we used Caspase-3-deficient mice to examine the role of Caspase-3 in hepatocarcinogenesis in a chemical (diethylnitrosamine, DEN)-induced HCC model. We found that Caspase-3 deficiency significantly increased DEN-induced HCC. Unexpectedly, Caspase-3 deficiency increased apoptosis induced by DEN and the subsequent compensatory proliferation. Intriguingly, we discovered that Caspase-3 deficiency increased the activation of p38 with and without DEN treatment. Moreover, we demonstrated that TNFα and IL1α stimulated increased activation of p38 in Caspase-3 KO hepatocytes compared with wild-type hepatocytes. Finally, we found that inhibition of p38 by SB202190 abrogated enhanced hepatocyte death, compensatory proliferation and HCC induced by DEN in Caspase-3-deficient mice. Overall, our data suggest that Caspase-3 inhibits chemical-induced hepatocarcinogenesis by suppressing p38 activation and hepatocyte death.
Web-GIS based Airbnb Information Web (2019)

With the splendid market in Beijing Airbnb, there is an increasing demand for relevant decision supporting tool. In decision-making, spatial analysis is significant for location relevant question solving. Therefore, the GIS should gain more attention from the business market. To demonstrate the importance of GIS application in business decision making. A web-GIS based Airbnb Beijing information web was generated with opensourced Airbnb house data and the open Application Programming Interface. It provide spatial analysis data and interactive geographic information visualization. In addition, with the case study of Airbnb in Beijing, the price prediction of Bed and Breakfast accommodation is explored with combined model. Development was executed with the User-Centred Design process, and from the feedbacks of the website testing user, the GIS is important and useful in decision supporting
Sideward Movement Approach to Extraposition from DP in English (2007)

There was a long debate between movement vs. base-generation analyses of extra position, which also revolved around the question of the landing site. So far many analyses (e.g., rightward movement analysis, stranding analysis, stylistic analysis, base generation analysis, PCM analysis) have been presented, but they all show some problems of their own, especially with regard to definiteness effect and the contrast between complement and adjunct extra positions with respect to Condition C. In this article, we show that these problems can be solved by the sideward movement approach combined with distributed deletion.
Hippo pathway activation mediates chemotherapy-induced anti-cancer effect and cardiomyopathy through causing mitochondrial damage and dysfunction (2023)

<b>Rationale:</b> Chemotherapy is a common clinical strategy for cancer treatment. However, the accompanied cardiomyopathy renders cancer patients under risk of another life-threatening condition. Whereas Hippo pathway is known to play key roles in both cancerogenesis and heart disease, it remains unclear whether Hippo pathway activation mediates chemotherapy-induced cardiomyopathy. <b>Methods and Results:</b> In human breast cancer cells, doxorubicin (DOX) significantly induced upregulation of Hippo kinase Mst1, inhibitory phosphorylation of YAP, mitochondrial damage, reduced cell viability and increased apoptosis. Hippo pathway inactivation by Mst1-siRNA transfection effectively improved cell survival and mitigated mitochondrial damage and cell apoptosis. Another anti-cancer drug YAP inhibitor verteporfin also induced lower cancer cell viability, apoptosis and mitochondrial injury. Chronic treatment with DOX <i>in vivo</i> (4 mg/kg/week for 6 weeks) caused mitochondrial damage and dysfunction, oxidative stress and cardiac fibrosis, while acute DOX treatment (16 mg/kg single bolus) also induced myocardial oxidative stress and mitochondrial abnormalities. Chronic treatment with verteporfin (2 months) resulted in cardiomyopathy phenotypes comparable to that by chronic DOX regimen. In transgenic mice with cardiac overexpression of kinase-dead mutant Mst1 gene, these adverse cardiac effects of DOX were significantly attenuated relative to wild-type littermates. <b>Conclusions:</b> Anti-cancer action of both DOX and verteporfin is associated with Hippo pathway activation. Such action on cardiac Hippo pathway mediates mitochondrial damage and cardiomyopathy.
Quantitative Lipoprotein Subclass and Low Molecular Weight Metabolite Analysis in Human Serum and Plasma by 1H NMR Spectroscopy in a Multilaboratory Trial (2018)

We report an extensive 600 MHz NMR trial of quantitative lipoprotein and small-molecule measurements in human blood serum and plasma. Five centers with eleven 600 MHz NMR spectrometers were used to analyze 98 samples including 20 quality controls (QCs), 37 commercially sourced, paired serum and plasma samples, and two National Institute of Science and Technology (NIST) reference material 1951c replicates. Samples were analyzed using rigorous protocols for sample preparation and experimental acquisition. A commercial lipoprotein subclass analysis was used to quantify 105 lipoprotein subclasses and 24 low molecular weight metabolites from the NMR spectra. For all spectrometers, the instrument specific variance in measuring internal QCs was lower than the percentage described by the National Cholesterol Education Program (NCEP) criteria for lipid testing [triglycerides <2.7%; cholesterol <2.8%; low-density lipoprotein (LDL) cholesterol <2.8%; high-density lipoprotein (HDL) cholesterol <2.3%], showing exceptional reproducibility for direct quantitation of lipoproteins in both matrixes. The average relative standard deviations (RSDs) for the 105 lipoprotein parameters in the 11 instruments were 4.6% and 3.9% for the two NIST samples, whereas they were 38% and 40% for the 37 commercially sourced plasmas and sera, respectively, showing negligible analytical compared to biological variation. The coefficient of variance (CV) obtained for the quantification of the small molecules across the 11 spectrometers was below 15% for 20 out of the 24 metabolites analyzed. This study provides further evidence of the suitability of NMR for high-throughput lipoprotein subcomponent analysis and small-molecule quantitation with the exceptional required reproducibility for clinical and other regulatory settings.
Frequent detection of immunoglobulin M anti-herpes simplex viral antibody in patients with primary biliary cirrhosis (2012)

We read with great interest the article by McNally et al.,1 who reported the involvement of a seasonally varying environmental agent in the etiology of primary biliary cirrhosis (PBC), and who have reported previously that a transient environmental agent may be involved in the etiology using a space-time clustering method among cases of PBC in a defined geographical population of northeast England.2 A combination of genetic predisposition and environmental factors are thought to contribute the etiology of PBC.3 As environmental factors, certain bacterial and viral infections, including Escherichia coli, mycobacteria, and a retrovirus, are reported to be involved.4 To date, however, no specific virus has been implicated in the pathogenesis, although cases of PBC tend to cluster within areas. Herpes simplex virus (HSV) is a hepatotropic virus, but it is an uncommon cause of hepatitis in immunocompetent adults. HSV hepatitis occurs in neonatal infections, pregnancy, and immunosuppressed patients. Recently, we frequently detected immunoglobulin M (IgM) anti-HSV antibody in patients with PBC. Twenty-two (55%) of 40 patients were positive (cutoff index >1.2) for IgM anti-HSV, 13 (33%) were negative (<0.8), and five (12%) were undetermined (0.8-1.2) (Fig. 1). Nineteen of 22 patients with positive IgM anti-HSV were positive for immunoglobulin G (IgG) anti-HSV, and three were negative. Nine of 13 patients with negative IgM anti-HSV were positive for IgG anti-HSV, and four were negative. Four of five undetermined patients were positive for IgG anti-HSV, and one was negative. Immunoglobulin M anti-HSV antibody in patients with primary biliary cirrhosis. Arrows and arrowheads represent antinuclear membrane antibody positivity and anticentromere antibody positivity, respectively. Nakamura et al.5 reported that two different progression types exist in PBC and that positive anti-gp210 (antinuclear membrane) and positive anticentromere antibodies represent the hepatic failure type and portal hypertension type, respectively. All five patients with antinuclear membrane antibodies showed strong positivity (Fig. 1, arrows). Five of 13 patients with anticentromere antibodies showed weak positivity (Fig. 1, arrowheads). Our results support environmental factors involved in the etiology of PBC, although further studies should be done to evaluate whether HSV is an infectious agent or whether IgM anti-HSV is the result of a response to cross-reactive cellular proteins. Keiichi Fujiwara M.D, Ph.D.*, Osamu Yokosuka M.D., Ph.D.*, * Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Cytotoxins in Disease (1970)

Lymphocytotoxic antibodies were found in 56 of 64 serum specimens from patients with systemic lupus erythematosus and 30 of 53 patients with rheumatoid arthritis. These cytotoxic antibodies characteristically reacted with a temperature optimum of 15°C as was found earlier with serums from patients with infectious mononucleosis, rubella and rubeola. The lymphotoxin found in systemic lupus was cytotoxic to autologous lymphocytes in 24 of 32 specimens tested. No correlation was found to the antibodies detected by radioactive labeled deoxyribonucleic acid (DNA) immunoelectrophoresis, antibodies against single-strand DNA and DNA. However, a definite association with antinuclear-factor activity and a weak association with latex-fixation tests were found. Association of specificity was tested against 18 different HL-A specificities, and antibodies against HL-A11, Te54, Te56 and Te59 were frequently observed.
Session 4 Overview: Oversampled ADCs (2005)

Start of the above-titled section of the conference proceedings record.
Genome sequences of both organelles of the grapevine rootstock cultivar ‘Börner’ (2020)

Abstract Genomic long reads of the interspecific grapevine rootstock cultivar ‘Börner’ ( Vitis riparia GM183 x Vitis cinerea Arnold) were used to assemble its chloroplast and mitochondrion genome sequences. We annotated 133 chloroplast and 172 mitochondrial genes including the RNA-editing sites. The organellar genomes were maternally inherited to ‘Börner’ from Vitis riparia .