gebhart/patrepeval huggingface dataset:
Chikungunya Fever Cases Identified in the Veterans Health Administration System, 2014 (2016)

CHIKV infection is an emerging problem among Veterans residing in or visiting areas with CHIKV transmission. Although overall mortality rates are low, clinicians in affected areas should be aware that older patients and patients with comorbidities may be at increased risk for severe disease.
Iterative mesh deformation for dense surface tracking (2009)

In this paper we present a new method to capture the temporal evolution of a surface from multiple videos. By contrast to most current methods, we introduce an algorithm that uses no prior of the nature of tracked surface. In addition, it does not require sparse features to constrain the deformation but only relies on strictly geometric information : a target set of 3D points and normals. Our approach is inspired by the Iterative Closest Point algorithm but handles large deformations of non-rigid surfaces. To this end, a mesh is iteratively deformed while enforcing local rigidity with respect to the reference model. This rigidity is preserved by diffusing it on local patches randomly seeded on the surface. The iterative nature of the algorithm combined with the softly enforced local rigidity allows to progressively evolve the mesh to fit the target data. The proposed method is validated and evaluated on several standard and challenging surface data sets acquired using real videos.
The future of zoonotic risk prediction (2021)

(Uploaded by Plazi for the Bat Literature Project) In the light of the urgency raised by the COVID-19 pandemic, global investment in wildlife virology is likely to increase, and new surveillance programmes will identify hundreds of novel viruses that might someday pose a threat to humans. To support the extensive task of laboratory characterization, scientists may increasingly rely on data-driven rubrics or machine learning models that learn from known zoonoses to identify which animal pathogens could someday pose a threat to global health. We synthesize the findings of an interdisciplinary workshop on zoonotic risk technologies to answer the following questions. What are the prerequisites, in terms of open data, equity and interdisciplinary collaboration, to the development and application of those tools? What effect could the technology have on global health? Who would control that technology, who would have access to it and who would benefit from it? Would it improve pandemic prevention? Could it create new challenges? This article is part of the theme issue 'Infectious disease macroecology: parasite diversity and dynamics across the globe'.
High-efficiency transformation of Plasmodium falciparum by the lepidopteran transposable element piggyBac (2005)

Functional analysis of the Plasmodium falciparum genome is restricted because of the limited ability to genetically manipulate this important human pathogen. We have developed an efficient transposon-mediated insertional mutagenesis method much needed for high-throughput functional genomics of malaria parasites. A drug-selectable marker, human dihydrofolate reductase, added to the lepidopteran transposon piggyBac, transformed parasites by integration into the P. falciparum genome in the presence of a transposase-expressing helper plasmid. Multiple integrations occurred at the expected TTAA target sites throughout the genome of the parasite. We were able to transform P. falciparum with this piggyBac element at high frequencies, in the range of 10(-3), and obtain stable clones of insertional mutants in a few weeks instead of 6-12 months. Our results show that the piggyBac transposition system can be used as an efficient, random integration tool needed for large-scale, whole-genome mutagenesis of malaria parasites. The availability of such an adaptable genetic tool opens the way for much needed forward genetic approaches to study this lethal human parasite.
An expert system approach for water management in case of drought (2002)

The reservoirs designed for the purpose of flood control have to face operational problems during periods of drought. Based on the drought monitoring method using the five indicators, streamflow, precipitation, temperature, groundwater and lake levels, the study developed an expert system for the water management of the four flood control reservoirs in case of drought. The developed system was based on the combination of the rules and heuristic knowledge from expert opinions, the control manuals of reservoirs involved, and a developed optimization model. Daily drought conditions were evaluated by the monitoring method and the recommendations of water release from each reservoir were then made by the developed system. The comparisons between the recommended water releases and their counterparts of the optimization model and the actual operation of reservoirs were made. It was found that the developed expert system has the advantage of flexibility, making water release recommendations over a strictly mathematical model.
Update on Retinal Vein Occlusion (2023)

Retinal vein occlusion represents the second leading cause of retinal vascular disorders, with a uniform sex distribution worldwide. A thorough evaluation of cardiovascular risk factors is required to correct possible comorbidities. The diagnosis and management of retinal vein occlusion have changed tremendously in the last 30 years, but the assessment of retinal ischemia at baseline and during follow-up examinations remains crucial. New imaging techniques have shed light on the pathophysiology of the disease and laser treatment, once the only therapeutic option, is now only one of the possible approaches with antivascular endothelial growth factors and steroid injections being preferred in most cases. Nowadays long-term outcomes are better than those achievable 20 years ago and yet, many new therapeutic options are under development, including new intravitreal drugs and gene therapy. Despite this, some cases still develop sight-threatening complications deserving a more aggressive (sometimes surgical) approach. The purpose of this comprehensive review is to reappraise some old but still valid concepts and to integrate them with new research and clinical data. The work will provide an overview of the disease's pathophysiology, natural history, and clinical features along with a detailed discussion on the advantages of multimodal imaging and of the different treatment strategies with the aim of providing retina specialists with the most updated knowledge in the field.
Feedback regulation of rRNA and tRNA synthesis and accumulation of free ribosomes after conditional expression of rRNA genes. (1985)

We have constructed a conditional rRNA gene expression system by fusing a plasmid-encoded rrnB operon to the lambda PL promoter/operator. It was thereby possible to study the events that lead to the regulation of chromosomal rRNA and tRNA synthesis after overproduction of rRNA. rRNA induction resulted in a 2-fold increase in 30S and 50S free ribosomal subunits, whereas the polysome fraction was unaffected. Overproduction of rRNA and "free" ribosomes produced a large repression of rRNA and tRNA synthesis from chromosomal genes and a smaller increase in the concentration of guanosine tetraphosphate. These results lend support to the ribosome feedback regulation model: rRNA and tRNA operons are negatively regulated, either directly or through some intermediate, by free, nontranslating ribosomes.
SNAP‐tag Based Proteomics Approach for the Study of the Retrograde Route (2012)

Proteomics is a powerful technique for protein identification at large scales. A number of proteomics approaches have been developed to study the steady state composition of intracellular compartments. Here, we report a novel vectorial proteomics strategy to identify plasma membrane proteins that undergo retrograde transport to the trans-Golgi network (TGN). This strategy is based on the covalent modification of the plasma membrane proteome with a membrane impermeable benzylguanine derivative. Benzylguanine-tagged plasma membrane proteins that are subsequently targeted to the retrograde route are covalently captured by a TGN-localized SNAP-tagged fusion protein, which allows for their identification. The approach was validated step-by-step using a well explored retrograde cargo protein, the B-subunit of Shiga toxin. It was then extended to the proteomics format. Among other hits we found one of the historically first identified cargo proteins that undergo retrograde transport, which further validated our approach. Most of the other hits were kinases, receptors or transporters. In conclusion, we have pioneered a vectorial proteomics approach that complements traditional methods for the study of retrograde protein trafficking. This approach is of generic nature and could in principle be extended to other endocytic pathways.
Redefining Health Care: Creating Value-based Competition on Results (2006)

A look at the North American health care system, issues of reform, value for money and services.
On the analysis of large-dimension reconfigurable suspended cable-driven parallel robots (2014)

In this paper, a new type of large-dimension reconfigurable suspended cable-driven parallel robots (CDPR) is introduced as a means to substitute for conventional methods of handing large and heavy parts across wide workspaces. The reconfigurability of the proposed CDPR offers better performances in term of workspace, flexibility and power consumption. A systematic procedure to solve a complex nonlinear optimization problem to find optimal reconfiguration for the robot is presented. Critical issues regarding various constraints and performance criteria are addressed. The robot can operate in offline reconfiguration or online reconfiguration modes which offer wide range of solutions to the end-users.
Whole transcriptome analysis reveals the key genes and noncoding RNAs related to follicular atresia in broilers (2022)

Broodiness, a maternal behavior, is accompanied by the atresia of follicles and the serious degradation of poultry reproductive performance. The comparison of follicles between brooding and laying hens is usually an ideal model for exploring the regulation mechanism of follicle atresia. In this study, we selected three brooding hens and three laying hens to collect their follicles for whole transcriptome sequencing. The results demonstrated different expression patterns between the follicles of brooding hens and laying hens. In the top 10 differentially expressed genes with the highest expression, <i>MMP10</i> was relatively low expressed in the follicles of brooding hens, but other nine genes were relatively highly expressed, including <i>LRR1</i>, <i>RACK1</i>, <i>SPECC1L</i>, <i>ABHD2</i>, <i>COL6A3</i>, <i>RPS17</i>, <i>ATRN</i>, <i>BIRC6</i>, <i>PGAM1</i> and <i>SPECC1L</i>. While miR-21-3p, miR-146a-5p, miR-142-5p and miR-1b-3p were highly expressed in the follicles of brooding hen, miR-106-5p, miR-451, miR-183, miR-7, miR-2188-5p and miR-182-5p were lowly expressed in brooding hen. In addition, we identified 124 lncRNAs specifically expressed in the follicles of brooding hens and 147 lncRNAs specifically expressed in the follicles of laying hens. Our results may provide a theoretical basis for further exploration of the molecular mechanism of broodiness in broilers.
SDN managed Network Slicing in Mobile Backhaul (2020)

This paper provides a solution for ultra reliable low latency communication (URLLC) module for the 5G Mobile Backhaul. This proposal considers network slicing based on Software Defined Networking (SDN) to deploy URLLC communications. This paper presents the design of the modules and algorithms that implement the network slicing functionality. It will be illustrated by applying it to a emulated Mobile Backhaul environment.
Free C-Terminal Resin-Bound Peptides: Reversal of Peptide Orientation via A Cyclization/Cleavage Protocol (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFree C-Terminal Resin-Bound Peptides: Reversal of Peptide Orientation via A Cyclization/Cleavage ProtocolRobert S. Kania, Ronald N. Zuckermann, and Charles K. MarloweCite this: J. Am. Chem. Soc. 1994, 116, 19, 8835–8836Publication Date (Print):September 1, 1994Publication History Published online1 May 2002Published inissue 1 September 1994https://pubs.acs.org/doi/10.1021/ja00098a064https://doi.org/10.1021/ja00098a064research-articleACS PublicationsRequest reuse permissionsArticle Views201Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (3)»Supporting Information Supporting Information Get e-Alerts
Genetic analysis of nonpathogenic Agrobacterium tumefaciens mutants arising in crown gall tumors (1995)

Little is known about the effect of the host on the genetic stability of bacterial plant pathogens. Crown gall, a plant disease caused by Agrobacterium tumefaciens, may represent a useful model to study this effect. Indeed, our previous observations on the natural occurrence and origin of nonpathogenic agrobacteria suggest that the host plant might induce loss of pathogenicity in populations of A. tumefaciens. Here we report that five different A. tumefaciens strains initially isolated from apple tumors produced up to 99% nonpathogenic mutants following their reintroduction into axenic apple plants. Two of these five strains were also found to produce mutants on pear and/or blackberry plants. Generally, the mutants of the apple isolate D10B/87 were altered in the tumor-inducing plasmid, harboring either deletions in this plasmid or point mutations in the regulatory virulence gene virG. Most of the mutants originating from the same tumor appeared to be of clonal origin, implying that the host plants influenced agrobacterial populations by favoring growth of nonpathogenic mutants over that of wild-type cells. This hypothesis was confirmed by coinoculation of apple rootstocks with strain D10B/87 and a nonpathogenic mutant.
Detection of non-identical duplicate consumer photographs (2004)

Consumers often make more than one photograph of the same scene, creating non-identical "duplicates" and similar "non-duplicates". In Kodak's consumer photography database, 19% of the images fall into this category. Automatic detection of duplicates, therefore, is extremely useful in consumer applications. In this paper, first we develop a model of the problem and introduce a new classification of different types of duplicates. Then, we introduce a novel framework that automatically distinguishes between non-identical duplicate and very similar non-duplicate images. Our approach is based on a multiple strategy framework that combines our knowledge about the geometry of multiple views of the same scene, the extraction of low-level features, the detection of a limited number of semantic objects, and domain knowledge. The approach consists of three stages: (1) global alignment, (2) detection of change areas, and (3) local analysis of change areas. We present a novel and extensive image duplicate database (255 image pairs from 60 rolls from 54 real consumers, labeled by 10 other people). We analyze labeling subjectivity in detail and present experiments using our approach.
Breaking Out the Traditional Polymerization: Tailoring the Shape, Structure, and Optical Properties of Polydopamine by Using CdTe Quantum Dots (2019)

Abstract The potential applications of shape‐controlled polymeric nanostructures demand well‐defined methods to create tailored shapes. On the other hand, polydopamine (PDA) is a novel polymer promising a variety of innovative applications in many different areas. Since there is no consensus on the pathways involved in the mechanism of formation of PDA, the control of the final morphologies of PDA nanostructures is a challenging task. Herein, it is demonstrated for the first time, how CdTe quantum dots (CdTe QDs) can be used to control the final shape of polymeric structures, in particular, PDA particles. Oxidative self‐polymerization of dopamine is performed in the presence of CdTe QDs, which triggers the formation of blue‐colored rod‐like PDA particles. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), UV‐Vis, Fourier transform infrared (FT‐IR) and Raman spectroscopies, and electrochemical techniques are employed to characterize the structural features of the rod‐like PDA particles. Herein, CdTe QDs modulate the oxidative polymerization of dopamine by the supramolecular assembly of PDA building blocks by π–π and hydrogen bonding interactions, coordination with cadmium ions, and electron transfer processes. The results illustrated here describe a new strategy to manipulate the morphology of PDA nanostructures leading to novel optical properties, opening new applications, and shedding light on the complex mechanism of PDA formation.
Control of the light-regulated current in rod photoreceptors by cyclic GMP, calcium, and l-cis-diltiazem. (1986)

The effect of calcium ions on the cGMP-activated current of outer segment membrane was examined by the excised-patch technique. Changes in the extracellular calcium concentration had marked effects on the cGMP-activated current, while changes in intracellular calcium concentration were ineffective. Changes in calcium concentration in the absence of cGMP had little, if any, effect on membrane conductance. These results suggest that both intracellular cGMP and extracellular calcium can directly affect the conductance underlying the light response in rod cells. The pharmacological agent l-cis-diltiazem reversibly inhibited the cGMP-activated current when applied to the intracellular side of an excised patch. When superfused over intact rod cells, l-cis-diltiazem reversibly blocked much of the normal light response. The isomer, d-cis-diltiazem, did not significantly affect either patches or intact rod cells. Thus, the light-regulated conductance has binding sites for both calcium and cGMP that may interact during the normal light response in rod cells and a site specific for l-cis-diltiazem that can be used to identify and further study the conductance mechanism.
Injection-locking properties of self pulsation in semiconductor lasers (1997)

The injection-locking properties of self pulsation in semiconductor lasers are studied, using a phenomenological approach, based on an analogy with laser models. It has been found that the locking range is directly proportional to the input power, rather than to the square root of the input power as in injection-locked microwaves or laser oscillators; the locking range is symmetric with respect to the self-pulsation frequency in the free-running case; in the locking state, the spectral linewidth of the self-pulsation peak is equal to that of the incoming signal. These theoretical results agree very well with experimental ones, obtained on a distributed feedback three-section laser.
Validation of IASI NH 3 columns at the single pixel scale from airborneandground-based measurements (2016)

info:eu-repo/semantics/nonPublished
The Realities and Economic Benefit of the Utilization of Fuel Cells as an Alternative Source of Energy: A Review (2015)

The 21st century has seen a critical need for alternative cleaner sources of energy and fuel cells are one of the technologies that have been developed to address the need. This article reviews the realities of fuel cell technologies as an alternative source of energy. It gives insight into the past, present, and future status of fuel cells as a way of addressing the energy crisis. It can be inferred from this article that the fuel cell industry continues to be constrained in its ability to commercialize the technology by a circular logic whereby it cannot generate significant commercial sales due to relatively high costs of units. It is imperative that this cycle be broken by converted actions of the fuel cell industry, the user community, and the governments. In spite of the challenges of commercialization, it was noted that fuel cells have been successfully delivering power to several prototypes and specialized applications in recent decades. The power output of a fuel cell stack is easily scalable to provide the right amount of electricity for a laptop computer, a small car, a city bus, or even utility generation and power building not connected to a national grid.
On isotropic tensors (1973)

1. An isotropic tensor is one the values of whose components are unaltered by any rotation of rectangular axes (with metric σ i ( dx i ) 2 ). Those up to order 4 in 2 and 3 dimensions have many applications. The results suggest a general theorem for tensors of order m in n dimensions, that any isotropic tensor can be expressed as a linear combination of products of δ and є tensors, where δ ij = 1 if i = j and 0 otherwise, and is 0 if any two of the i 1 to i n are equal, 1 if i 1 … i n is an even permutation of 1, 2, 3, …, n , and – 1 if it is an odd permutation.
The stability of mechanical calibration for a kV cone beam computed tomography system integrated with linear acceleratora) (2005)

The geometric accuracy and precision of an image-guided treatment system were assessed. Image guidance is performed using an x-ray volume imaging (XVI) system integrated with a linear accelerator and treatment planning system. Using an amorphous silicon detector and x-ray tube, volumetric computed tomography images are reconstructed from kilovoltage radiographs by filtered backprojection. Image fusion and assessment of geometric targeting are supported by the treatment planning system. To assess the limiting accuracy and precision of image-guided treatment delivery, a rigid spherical target embedded in an opaque phantom was subjected to 21 treatment sessions over a three-month period. For each session, a volumetric data set was acquired and loaded directly into an active treatment planning session. Image fusion was used to ascertain the couch correction required to position the target at the prescribed iso-center. Corrections were validated independently using megavoltage electronic portal imaging to record the target position with respect to symmetric treatment beam apertures. An initial calibration cycle followed by repeated image-guidance sessions demonstrated the XVI system could be used to relocate an unambiguous object to within less than 1 mm of the prescribed location. Treatment could then proceed within the mechanical accuracy and precision of the delivery system. The calibration procedure maintained excellent spatial resolution and delivery precision over the duration of this study, while the linear accelerator was in routine clinical use. Based on these results, the mechanical accuracy and precision of the system are ideal for supporting high-precision localization and treatment of soft-tissue targets.