gebhart/patrepeval huggingface dataset:
Movement-Related Theta Rhythm in Humans: Coordinating Self-Directed Hippocampal Learning (2012)

The hippocampus is crucial for episodic or declarative memory and the theta rhythm has been implicated in mnemonic processing, but the functional contribution of theta to memory remains the subject of intense speculation. Recent evidence suggests that the hippocampus might function as a network hub for volitional learning. In contrast to human experiments, electrophysiological recordings in the hippocampus of behaving rodents are dominated by theta oscillations reflecting volitional movement, which has been linked to spatial exploration and encoding. This literature makes the surprising cross-species prediction that the human hippocampal theta rhythm supports memory by coordinating exploratory movements in the service of self-directed learning. We examined the links between theta, spatial exploration, and memory encoding by designing an interactive human spatial navigation paradigm combined with multimodal neuroimaging. We used both non-invasive whole-head Magnetoencephalography (MEG) to look at theta oscillations and Functional Magnetic Resonance Imaging (fMRI) to look at brain regions associated with volitional movement and learning. We found that theta power increases during the self-initiation of virtual movement, additionally correlating with subsequent memory performance and environmental familiarity. Performance-related hippocampal theta increases were observed during a static pre-navigation retrieval phase, where planning for subsequent navigation occurred. Furthermore, periods of the task showing movement-related theta increases showed decreased fMRI activity in the parahippocampus and increased activity in the hippocampus and other brain regions that strikingly overlap with the previously observed volitional learning network (the reverse pattern was seen for stationary periods). These fMRI changes also correlated with participant's performance. Our findings suggest that the human hippocampal theta rhythm supports memory by coordinating exploratory movements in the service of self-directed learning. These findings directly extend the role of the hippocampus in spatial exploration in rodents to human memory and self-directed learning.
Identifying protective antigens of Staphylococcus aureus , a pathogen that suppresses host immune responses (2011)

Staphylococcus aureus infections result in abscesses as well as septicemia. Even with therapy, abscesses can persist or even reoccur, as staphylococcal infections fail to induce protective immune responses. Here, we show that prior infection with certain attenuated strains may elicit protective immunity. A closer examination reveals that protection correlates with antibody responses elicited on exposure to particular attenuated variants. Linear regression analysis was used to compare reduction in staphylococcal disease and antibody responses to infection with wild-type and attenuated variants. This analysis identified protective antigens that, when tested as vaccines in mice, elicited disease protection. Protection afforded by attenuated strains correlates in part with the ability of Staphylococcus aureus to modulate B cell responses via protein A (spa encoded). We designate this approach "genetic vaccinology," since it exploits genetic variants to draw a correlation between disease protection and humoral immune responses for the deduction of vaccine antigens. Genetic vaccinology is particularly useful for microbes that do not elicit natural protective immunity during infection.
Spatial Degrees of Freedom Exploration and Analog Beamforming Designs for Signature Spatial Modulation (2021)

In this paper, we focus on developing efficient multi-configuration selection mechanisms by exploiting the spatial degrees of freedom (DoF), and leveraging the simple design benefits of spatial modulation (SM). Notably, the SM technique, as well as its variants, faces the following critical challenges: (i) the performance degradation and difficulty in improving the system performance for higher-level QAM constellations, and (ii) the vast complexity cost in precoder designs particularly for the increasing system dimension and amplitude-phase modulation (APM) constellation dimension. Given this situation, we first investigate two independent modulation domains, i.e., the original signal- and spatial-constellations. By exploiting the analog shift weighting and the virtual spatial signature technologies, we introduce the signature spatial modulation (SSM) concept, which is capable of guaranteing superior trade-offs among spectral- and cost-efficiencies, and system bit error rate (BER) performance. Besides, we develop an analog beamforming for SSM by solving the introduced unconstrained Lagrange dual function minimization problem. Numerical results manifest the performance gain brought by our developed analog beamforming for SSM.
Discovery and Characterization of Aminopiperidinecoumarin Melanin Concentrating Hormone Receptor 1 Antagonists (2005)

4-(1-Benzo[1,3]dioxol-5-ylmethylpiperidine-4-ylmethyl)-6-chlorochromen-2-one (7) is a potent, orally bioavailable melanin concentrating hormone receptor 1 (MCHr1) antagonist that causes dose-dependent weight loss in diet-induced obese mice. Further evaluation of 7 in an anesthetized dog model of cardiovascular safety revealed adverse hemodynamic effects at a plasma concentration comparable to the minimally effective therapeutic concentration. These results highlight the need for scrutiny of the cardiovascular safety profile of MCHr1 antagonists.
Depth buffer compression for stochastic motion blur rasterization (2011)

Previous depth buffer compression schemes are tuned for compressing depths values generated when rasterizing static triangles. They provide generous bandwidth usage savings, and are of great importance to graphics processors. However, stochastic rasterization for motion blur and depth of field is becoming a reality even for real-time graphics, and previous depth buffer compression algorithms fail to compress such buffers due to the irregularity of the positions and depths of the rendered samples. Therefore, we present a new algorithm that targets compression of scenes rendered with stochastic motion blur rasterization. If possible, our algorithm fits a single time-dependent predictor function for all the samples in a tile. However, sometimes the depths are localized in more than one layer, and we therefore apply a clustering algorithm to split the tile of samples into two layers. One time-dependent predictor function is then created per layer. The residuals between the predictor and the actual depths are then stored as delta corrections. For scenes with moderate motion, our algorithm can compress down to 65% compared to 75% for the previously best algorithm for stochastic buffers.
Should obstetricians support a ‘term cephalic trial’? (2003)

Recent analyses of the published data suggest that the risks of elective Caesarean delivery in an uncomplicated pregnancy may not outweigh the benefits of vaginal birth by as much as has been supposed. Indeed, this balance may be so close that the place of elective Caesarean delivery of a term cephalic baby might be considered as a worthwhile subject of a randomised controlled trial. We discuss the potential consequences of such a trial and what effect it could have on obstetric practice.
A study of voice/non-voice discrimination method using neural networks for integrated packet switching system (1989)

Voice packet technology, which handles analog signals such as DTMF (dual-tone multifrequency) signals and voiceband data as well as voice, image and data, is a key technology for a fast packet-switching system for multimedia communication. Transmission of voice signal in packets involves echo canceling, bandwidth-compression coding, and silence compression. However, if nonvoice signals like DTMF signals and voiceband data undergo such processing, communication quality may deteriorate due to malfunction or erroneous detection at the receiving side. The authors have developed a voice/nonvoice discrimination method by combining digital signal processing and a neural network. They confirmed that the method showed good characteristics by simulation and by running it on a DSP.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Engineering ePTEN, an enhanced PTEN with increased tumor suppressor activities (2014)

The signaling lipid phosphatidylinositol (3,4,5)-trisphosphate (PIP3) is a key regulator of cell proliferation, survival, and migration and the enzyme that dephosphorylates it, phosphatase and tensin homolog (PTEN), is an important tumor suppressor. As excess PIP3 signaling is a hallmark of many cancers, its suppression through activation of PTEN is a potential cancer intervention. Using a heterologous expression system in which human PTEN-GFP is expressed in Dictyostelium cells, we identified mutations in the membrane-binding regulatory interface that increase the recruitment of PTEN to the plasma membrane due to enhanced association with PI(4,5)P2. We engineered these into an enhanced PTEN (ePTEN) with approximately eightfold increased ability to suppress PIP3 signaling. Upon expression in human cells, ePTEN decreases PIP3 levels in the plasma membrane; phosphorylation of AKT, a major downstream event in PIP3 signaling; and cell proliferation and migration. Thus, the activation of PTEN can readjust PIP3 signaling and may serve as a feasible target for anticancer therapies.
Kinetics of O2 Entry and Exit in Monomeric Sarcosine Oxidase via Markovian Milestoning Molecular Dynamics (2016)

The flavoenzyme monomeric sarcosine oxidase (MSOX) catalyzes a complex set of reactions currently lacking a consensus mechanism. A key question that arises in weighing competing mechanistic models of MSOX function is to what extent ingress of O2 from the solvent (and its egress after an unsuccessful oxidation attempt) limits the overall catalytic rate. To address this question, we have applied to the MSOX/O2 system the relatively new simulation method of Markovian milestoning molecular dynamics simulations, which, as we recently showed [ Yu et al. J. Am. Chem. Soc. 2015 , 137 , 3041 ], accurately predicted the entry and exit kinetics of CO in myoglobin. We show that the mechanism of O2 entry and exit, in terms of which possible solvent-to-active-site channels contribute to the flow of O2, is sensitive to the presence of the substrate-mimicking competitive inhibitor 2-furoate in the substrate site. The second-order O2 entry rate constants were computed to be 8.1 × 10(6) and 3.1 × 10(6) M(-1) s(-1) for bound and apo MSOX, respectively, both of which moderately exceed the experimentally determined second-order rate constant of (2.83 ± 0.07) × 10(5) M(-1) s(-1) for flavin oxidation by O2 in MSOX. This suggests that the rate of flavin oxidation by O2 is likely not strongly limited by diffusion from the solvent to the active site. The first-order exit rate constants were computed to be 10(7) s(-1) and 7.2 × 10(6) s(-1) for the apo and bound states, respectively. The predicted faster entry and slower exit of O2 for the bound state indicate a longer residence time within MSOX, increasing the likelihood of collisions with the flavin isoalloxazine ring, a step required for reduction of molecular O2 and subsequent reoxidation of the flavin. This is also indirectly supported by previous experimental evidence favoring the so-called modified ping-pong mechanism, the distinguishing feature of which is an intermediate complex involving O2, the flavin, and the oxidized substrate simultaneously in the cavity. These findings demonstrate the utility of the Markovian milestoning approach in contributing new understanding of complicated enyzmatic function.
New series expansion representations for spherical wave functions (2000)

New series expansion representations of the normalized functions Pmn(cos θ)=¯P(cos θ), Smn(cos θ)=(m/sin θ)¯P(cos θ), and Dmn(cos θ)=(d/dθ)¯P(cos θ) are derived, where ¯P(cos θ) is a new normalized associated Legendre function valid for n>0, −n≤m≤n, and at 0≤θ≤π. The usual normalized associated Legendre function ¯P(cos θ) is valid only for m≥0, and hence is different from ¯P|m|n(cos θ). The derived functions are important for applications where vector spherical wave functions are used to analyze the electromagnetic fields. The functions derived here can be computed nonrecursively, and the computation time is of the same order as that using recurrence relations. ©2000 John Wiley & Sons, Inc. Microwave Opt Technol Lett 24: 131–133, 2000.
Decreased activity of hepatic P-glycoprotein in the isolated perfused liver of the adjuvant arthritis rat (2002)

1. We investigated the hepatobiliary transport of doxorubicin in the isolated perfused liver prepared from the adjuvant arthritis rat, an animal model for rheumatoid arthritis, to examine the hepatic P-glycoprotein activity in the adjuvant arthritis rat. 2. Liver was isolated from the normal and the adjuvant arthritis rat and perfused for 60 min with recirculating buffer and the perfusate and bile samples were collected at timed interval. 3. The elimination of doxorubicin in the adjuvant arthritis rat tended to be reduced, but it was not significantly different from the normal rat. Biliary clearance (CL(bile)) in the normal rat was 1.93 +/- 0.48 ml min(-1), whereas, CL(bile) in the adjuvant arthritis rat was significantly decreased to 0.40 +/- 0.13 ml min(-1). 4. CL(bile) was markedly decreased to about 0.15 ml min(-1) in the presence of 100 microM verapamil in both types of rat. Methotrexate treatment had no effect on CL(bile) in both the normal and adjuvant arthritis rat (2.18 +/- 0.22 and 0.47 +/- 0.22 ml min(-1), respectively). 5. The results suggest that the hepatic P-glycoprotein activity was markedly decreased in the adjuvant arthritis rat and the effect of methotrexate on the hepatic P-glycoprotein activity did not corresponded to its anti-inflammatory effect.
Long-term follow-up results of endoscopic treatment of gastroesophageal reflux disease with the MUSE™ endoscopic stapling device (2015)

In our multi-center prospective study, the MUSE™ stapling device appears to be safe and effective in improving symptom scores as well as reducing PPI use in patients with GERD. These results appeared to be equal to or better than those of the other devices for endoluminal GERD therapy. Future studies with larger patient series, sham control group, and greater number of staples are awaited.
Depressed Baroreflex Sensitivity in Patients With Obstructive Sleep Apnea (1996)

Muscle nerve sympathetic activity (MSA), the interval between two R-waves in the ECG, or the interbeat interval (RR-interval), and blood pressure (BP) were recorded in 10 awake patients with obstructive sleep apnea (OSA) and in nine sex- and age-matched controls. Changes in RR-interval and MSA, evoked by sodium nitroprusside-induced reduction of BP, were used to quantitate baroreflex sensitivity. Both the cardiac (expressed as the RR-interval versus mean arterial BP slope) and the muscle sympathetic (mean MSA area versus diastolic BP slope) baroreflex sensitivity were depressed in patients as compared with controls. Cardiac baroreflex slope sensitivity (expressed as a regression coefficient) was 5.5 +/- 1.2 (mean +/- SEM) in patients and 9.6 +/- 0.96 in controls (p < 0.05). The corresponding figures for the sympathetic slope sensitivity were -4.9 +/- 0.9 and -13.1 +/- 2.3, respectively (p < 0.05). Differences remained after stepwise correction for age, body mass index (BMI), and to some extent BP. Resting MSA correlated with cardiac (r = 0.67, p < 0.003) and sympathetic (r = 0.56, p < 0.025) baroreflex sensitivity in the entire study group. We conclude that OSA patients exhibit an impaired baroreflex sensitivity to a hypotensive stimulus, which may represent an adaptive response to changes in BP or hypoxemia occurring in association with nocturnal apneas. Baroreflex adaptation may also contribute to the augmentation of resting MSA observed in OSA patients in this as well as in a previous study.
SARAH: A Novel Method for Machine Learning Problems Using Stochastic\n Recursive Gradient (2017)

In this paper, we propose a StochAstic Recursive grAdient algoritHm (SARAH),\nas well as its practical variant SARAH+, as a novel approach to the finite-sum\nminimization problems. Different from the vanilla SGD and other modern\nstochastic methods such as SVRG, S2GD, SAG and SAGA, SARAH admits a simple\nrecursive framework for updating stochastic gradient estimates; when comparing\nto SAG/SAGA, SARAH does not require a storage of past gradients. The linear\nconvergence rate of SARAH is proven under strong convexity assumption. We also\nprove a linear convergence rate (in the strongly convex case) for an inner loop\nof SARAH, the property that SVRG does not possess. Numerical experiments\ndemonstrate the efficiency of our algorithm.\n
Novel Real-Time Tone-Mapping Operator for Noisy Logarithmic CMOS Image Sensors (2016)

Logarithmic CMOS image sensors are easily able, at video rates, to capture scenes where the dynamic range (DR) is high. However, tone mapping is required to output resulting images or videos to standard low-DR displays. This article proposes a new method, designed especially for logarithmic CMOS image sensors, which can suffer from temporal, and residual fixed pattern, noise. The novel tone mapping, a global operator based on histogram adjustment, uses a model of the camera noise to ensure that the mapping does not amplify the noise above a display threshold. Moreover, to reduce the likelihood of flickering, a temporal adaptation process is incorporated into the histogram calculation. Furthermore, to reduce complexity for real-time processing, a fixed-point implementation is designed for the proposed tone mapping. The novel operator and its fixed-point design are validated through offline and real-time experiments with a logarithmic CMOS image sensor.
A 1-Year Double-Blind Study of 2 Doses of Long-Acting Risperidone in Stable Patients With Schizophrenia or Schizoaffective Disorder (2006)

In this 1-year study, long-acting risperidone was associated with low relapse and rehospitalization rates, indicating that doses of 25 to 50 mg are appropriate for long-term treatment in schizophrenia.
Fluorescent silver nanoclusters as DNA probes (2013)

Fluorescent silver nanoclusters (few atoms, quantum sized) have attracted much attention as promising substitutes for conventional fluorophores. Due to their unique environmental sensitivities, new fluorescent probes have been developed based on silver nanoclusters for the sensitive and specific detection of DNA. In this review we present the recent discoveries of activatable and color-switchable properties of DNA-templated silver nanoclusters and discuss the strategies to use these new properties in DNA sensing.
Frontispiece: Irreversible Denaturation of Proteins through Aluminum‐Induced Formation of Backbone Ring Structures (2014)

B. Song, X. Gao, F. Huang et al. describe in their Communication on page 6358 ff. the ability of Al ions to induce the formation of backbone ring structures in a wide range of peptides, including neurodegenerative disease related motifs.
Recherches archéologiques à Laos-Marcellina (Calabre, CS) (2012)

Durant l’été 2011, l’équipe franco-italienne a mené la troisième campagne de fouille et de prospection archéologique à Laos-Marcellina. Nous rendons compte ici, d’une part, de la fouille menée sous la direction de Gregorio Aversa (Surintendance de la Calabre) dans le parc archéologique de Marcellina et, d’autre part, de la prospection du territoire, coordonnée par Alain Duplouy (Université Paris 1), Priscilla Munzi (Centre Jean Bérard) et Alfonso Santoriello (Université de Salerne), dans la b...
ChemInform Abstract: 4‐Acetamidophenyl Esters and 4‐Acetamidoanilides of L‐Arginine, p‐ Guanidino‐L‐phenylalanine, L‐Lysine, N2‐(D‐Fructos‐3‐O‐yl and D‐Glucos‐ 3‐O‐yl)acetyl‐L‐lysine as Potential Acrosin Inhibitors. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The Design of a Basic CSCW Environment The Collaborative Desktop Experience (2007)

: From an analysis of co-operative work as a collaborative process in an information society we state requirements that a CSCW environment should meet. From these we have designed CoDesk, the Collaborative Desktop, a basic environment for CSCW that in its original form looks rather mundane but has the potential to be used both as building blocks for specific CSCW environments and as a fundament for new CSCW systems and applications. CoDesk has been designed in an iterative prototyping process, which is described and evaluated. How new interaction styles can be used in a CSCW environment is presented and analysed. Introduction In this paper we describe our design of a basic environment for CSCW. We start with a discussion of a general framework for CSCW which leads to some basic design implications. In a further elaboration on this design we review some earlier CSCW system to pull out some guidelines for a more detailed design, which has been accomplished using user-centred design met...
ChemInform Abstract: A Route to Functionalized 1,5‐Dicarbonyl Systems via Heterodiene Cycloadditions of a 2‐Acyl‐2‐enoic Acid. (1988)

Abstract Chromene‐3‐carboxylic acid (I) undergoes cycloaddition with the enol ether (IIa) and (IIb) or the ketene acetal (IIc) to give the pyrans (III) and the stereoisomers (IVa) and (IVb).
JPO Editor’s Comments (2018)

Passion is defined as an intense desire or enthusiasm for something. One of the attributes that I appreciate about the field of P&O is the shared passion that practitioners and other P&O professionals have for their work, specifically in helping individuals with disability achieve a higher quality of life. I thoroughly enjoy speaking with my colleagues in P&O and hearing the passion for their life’s calling coming out. Not only is it motivating and inspirational, but it’s also contagious! However, we shouldn’t keep this passion to ourselves. Instead, we should be using our passion for P&O to educate others and grow our field. Sharing your passion with individuals outside the field, particularly young people, serves to stimulate their curiosity and encourages them to learn more about what we do. Earlier this week, I was speaking with a father whose daughter is a young 20-something who is considering applying to P&O school. Her interest in P&O was greatly facilitated by shadowing experiences provided by individuals in both the P&O manufacturing sector and clinical practice. These practitioners deserve commendations and gratitude for sharing their time with this young person and encouraging her to enter the profession. I hope that, if approached, you will consider providing similar opportunities to young people in your community so they can witness your passion for the field firsthand. In addition, you might consider participating in career days at local high schools or mentoring student design groups to create awareness about the P&O field. Young people are fascinated by technology and we obviously work with a lot of interesting devices, so exposing them to the P&O field is a potential win for everyone involved. As always, we would love to hear your ideas for growing JPO’s stature in the field while increasing its relevance to your profession. Please feel free to contact me or any of the Editorial Board members with your thoughts.