gebhart/patrepeval huggingface dataset:
Optical and electrochemical sensing methods for the detection of food contaminants (2016)

A portable and low cost fluorescence set-up to quantify the concentrations of Ochratoxin A(OTA) in real samples was developed. The detection through the device consist of anultraviolet light at 365 nm and an photo detector or a CMOS sensor controlled by anexecutable interface designed in LabVIEW or MATLAB. It has been reported that OTA is naturally fluorescent, so it allows the user to get a UV LED to excite the sample, get a value involtage when a photodetector is employed or a photograph of the OTA under excitationconditions, and process that image in order to predict the concentrations of the sample. Tocapture and process the image, in an automatically manner, the system was completely basedon the Red, Green and Blue (RGB) components. The linearity for OTA obtained in the rangeof concentrations corresponds to 2-40 µg/L. Immunoaffinity columns (IAC) and molecularimprinted polymer columns (MIP) were used with cocoa, beer and wine samples. Theobtained results were cross-validated using chromatographic method such as HPLC and theFluoroskan equipment. The developed setup is easy to use, economical and portable. Besides,the use of new tendencies was included such as employ the smartphone to detect OTA and thecreation of an APP. Fluorescence image data from the smartphone camera are analyzed by apersonal computer and presented in RGB components, where the image is sent to thecomputer by WIFI and the smartphone is used as a power source too. Finally, an APP forandroid system was created to capture the image and provides the RGB values. At the end, theuse of image processing to quantify the OTA in real samples without incorporated IAC or MIPcolumns to extract the mycotoxin from a complex solution, employing colorimetric techniquesand color analysis.
Mitigating the Effects of Process Variation in Ultra-low Voltage Chip Multiprocessors using Dual Supply Voltages and Half-Speed Units (2011)

Energy efficiency is a primary concern for microprocessor designers. One very effective approach to improving processor energy efficiency is to lower its supply voltage to very near to the transistor threshold voltage. This reduces power consumption dramatically, improving energy efficiency by an order of magnitude. Low voltage operation, however, increases the effects of parameter variation resulting in significant frequency heterogeneity between (and within) otherwise identical cores. This heterogeneity severely limits the maximum frequency of the entire CMP. We present a combination of techniques aimed at reducing the effects of variation on the performance and energy efficiency of near-threshold, many-core CMPs. Dual Voltage Rail (DVR), mitigates core-to-core variation with a dual-rail power delivery system that allows post-manufacturing assignment of different supply voltages to individual cores. This speeds up slow cores by assigning them to a higher voltage and saves power on fast cores by assigning them to a lower voltage. Half-Speed Unit (HSU) mitigates within-core variation by halving the frequency of select functional blocks with the goal of boosting the frequency of individual cores, thus raising the frequency ceiling for the entire CMP. Together, these variation-reduction techniques result in almost 50% improvement in CMP performance for the same power consumption over a mix of workloads.
Establishment and consolidation of the new regime (1987)

Mao Tse-tung was clearly the unchallenged leader of the Chinese Communist Party (CCP) throughout the 1949-57 period. In this period, broad agreement existed within the CCP leadership on adopting the Soviet model of socialism. The essence of Mao's program for revolution before 1949 had been the need to address Chinese realities, and he was not about to disown that principle during the stage of building socialism. Differences in economic and cultural levels, agricultural patterns, local customs, and ethnic composition all required suitably varied responses. The crucial difference, however, was the degree of CCP presence in various areas before 1949. In addition to gradualism, the common program adopted the classic united front tactic of narrowly defining enemies as 'imperialism, feudalism and bureaucratic capitalism'. The crucial task for the new liberated areas generally was land reform. To this task the CCP brought experience and personnel that were often lacking for the more complex conditions of the cities.
Role of Rifampin against Propionibacterium acnes Biofilm In Vitro and in an Experimental Foreign-Body Infection Model (2012)

Propionibacterium acnes is an important cause of orthopedic-implant-associated infections, for which the optimal treatment has not yet been determined. We investigated the activity of rifampin, alone and in combination, against planktonic and biofilm P. acnes in vitro and in a foreign-body infection model. The MIC and the minimal bactericidal concentration (MBC) were 0.007 and 4 μg/ml for rifampin, 1 and 4 μg/ml for daptomycin, 1 and 8 μg/ml for vancomycin, 1 and 2 μg/ml for levofloxacin, 0.03 and 16 μg/ml for penicillin G, 0.125 and 512 μg/ml for clindamycin, and 0.25 and 32 μg/ml for ceftriaxone. The P. acnes minimal biofilm eradication concentration (MBEC) was 16 μg/ml for rifampin; 32 μg/ml for penicillin G; 64 μg/ml for daptomycin and ceftriaxone; and ≥128 μg/ml for levofloxacin, vancomycin, and clindamycin. In the animal model, implants were infected by injection of 10⁹ CFU P. acnes in cages. Antimicrobial activity on P. acnes was investigated in the cage fluid (planktonic form) and on explanted cages (biofilm form). The cure rates were 4% for daptomycin, 17% for vancomycin, 0% for levofloxacin, and 36% for rifampin. Rifampin cured 63% of the infected cages in combination with daptomycin, 46% with vancomycin, and 25% with levofloxacin. While all tested antimicrobials showed good activity against planktonic P. acnes, for eradication of biofilms, rifampin was needed. In combination with rifampin, daptomycin showed higher cure rates than with vancomycin in this foreign-body infection model.
The role of solvent structure in the absorption spectrum of solvated electrons: Mixed quantum/classical simulations in tetrahydrofuran (2005)

In polar fluids such as water and methanol, the peak of the solvated electron's absorption spectrum in the red has been assigned as a sum of transitions between an s-like ground state and three nearly degenerate p-like excited states bound in a quasispherical cavity. In contrast, in weakly polar solvents such as tetrahydrofuran (THF), the solvated electron has an absorption spectrum that peaks in the mid-infrared, but no definitive assignment has been offered about the origins of the spectrum or the underlying structure. In this paper, we present the results of adiabatic mixed quantum/classical molecular dynamic simulations of the solvated electron in THF, and provide a detailed explanation of the THF-solvated electron's absorption spectrum and electronic structure. Using a classical solvent model and a fully quantum mechanical excess electron, our simulations show that although the ground and first excited states are bound in a quasispherical cavity, a multitude of other, nearby solvent cavities support numerous, nearly degenerate, bound excited states that have little Franck-Condon overlap with the ground state. We show that these solvent cavities, which are partially polarized so that they act as electron trapping sites, are an inherent property of the way THF molecules pack in the liquid. The absorption spectrum is thus assigned to a sum of bound-to-bound transitions between a localized ground state and multiple disjoint excited states scattered throughout the fluid. Furthermore, we find that the usual spherical harmonic labels (e.g., s-like, p-like) are not good descriptors of the excited-state wave functions of the solvated electron in THF. Our observation of multiple disjoint excited states is consistent with femtosecond pump-probe experiments in the literature that suggest that photoexcitation of solvated electrons in THF causes them to relocalize into solvent cavities far from where they originated.
Original Articles LOCALLY RECURRENT PROSTATE TUMORS FOLLOWING EITHER RADIATION THERAPY OR RADICAL PROSTATECTOMY HAVE IMMUNOREACTMTY CHANGES IN KI-67 LABELING INDEX, P53 AND BCL-2 (1998)

Purpose: We compare the biological phenotype of recurrent prostatic tumors after definitive local therapy (radiation or radical prostatectomy) with that of the same tumors before treatment. Materials and Methods: Cellular proliferation (Ki-67 labeling index), p53 nuclear reactivity and bcl-2 immunoreactivity were determined in pretreatment and posttreatment tumor specimens from 13 patients with local tumor recurrence following radiation, and in 18 patients with local tumor recurrence following radical prostatectomy. Results: Mean Ki-67 labeling index increased approximately 2-fold in locally recurrent tumors after radiation (10.5 versus 5.6%, p = 0.0008) or surgery (6.0 versus 3.2%, p = 0.0025) when compared with pretreatment tumors. We noted p53 nuclear reactivity in a significantly higher proportion of recurrences than in pretreatment tumors following radiation (54 versus 8%, p = 0.032) and surgery (39 versus 5%, p = 0.022). Although bcl-2 immunoreactivity was also seen in a higher proportion of recurrent tumors, this difference did not reach statistical significance for either radiation or surgery. Conclusions: Recurrent tumors following either radiation or surgery differ significantly from the corresponding pretreatment tumors with respect to cellular proliferation and p53 nuclear reactivity.
Distinct features of human myeloid cell cytokine response profiles identify neutrophil activation by cytokines as a prognostic feature during tuberculosis and cancer1 (2019)

ABSTRACT Myeloid cells are a vital component of innate immunity and comprise of monocytes, macrophages, dendritic cells and granulocytes. How myeloid cell lineage affects activation states in response to cytokines remains poorly understood. The cytokine environment and cellular infiltrate during an inflammatory response may contain prognostic features that could predict disease outcome. Here we analyzed the transcriptional responses of human monocytes, macrophages, dendritic cells and neutrophils in response to stimulation by IFN-γ, IFN-β IFN-λ, IL-4, IL-13 and IL-10 cytokines, to better understand the heterogeneity of activation states in inflammatory conditions. This generated a myeloid cell cytokine specific response matrix that can infer representation of myeloid cells and the cytokine environment they encounter during infection and in tumors. Neutrophils were highly responsive to type 1 and type 2 cytokine stimulation but did not respond to IL-10. We identified transcripts specific to IFN-β stimulation, whereas other IFN signature genes were upregulated by both IFN-γ and IFN-β. When we used our matrix to deconvolute blood profiles from tuberculosis patients, the IFN-β specific neutrophil signature was reduced in TB patients with active disease whereas the shared response to IFN-γ and IFN-β in neutrophils was increased. When applied to glioma patients, transcripts of neutrophils exposed to IL-4 or IL-13 and monocyte responses to IFN-γ or IFN-β emerged as opposing predictors of patient survival. Hence, by dissecting how different myeloid cells respond to cytokine activation, we can delineate biological roles for myeloid cells in different cytokine environments during disease processes, especially during infection and tumor progression.
Airway Inflammation in Exercise-Induced Bronchospasm Occurring in Athletes Without Asthma (2008)

Exercise-induced bronchospasm (EIB) occurs in athletes with and without asthma. Studies have suggested an inflammatory basis for EIB in asthmatics; however whether inflammation plays a similar role in EIB in athletes without asthma remains unclear. Our objective was to determine whether there is evidence of an inflammatory basis for exercise-induced bronchospasm occurring in non-asthmatic athletes. Ninety-six athletes without asthma from varsity college teams underwent eucapnic voluntary hyperventilation testing. Sputum was induced from subjects with hypertonic saline inhalation post-eucapnic voluntary hyperventilation testing and was analyzed with enzyme-linked immunosorbent assays for IL-5, IL-8, IL-13, cysteinyl-leukotrienes, prostaglandin E2, histamine, leukotriene B4, and thromboxane B2. In addition, inflammatory (neutrophils, lymphocytes, eosinophils, and macrophages) and epithelial cell counts in sputum were recorded. Multivariate regression modeling showed a significant correlation between concentrations of select inflammatory mediators after eucapnic voluntary hyperventilation testing and severity of EIB. Means of the log-transformed concentrations of inflammatory mediators in EIB-positive athletes were significantly higher post-eucapnic voluntary hyperventilation than in EIB-negative athletes. Similar findings were not demonstrated with inflammatory cells. Concentrations of inflammatory mediators are higher in EIB-positive athletes than in EIB-negative athletes without asthma after eucapnic voluntary hyperventilation testing. The severity of EIB in our cohort also is significantly correlated with increased concentrations of select inflammatory mediators suggesting a potential inflammatory basis for EIB in athletes without asthma.
From simple to complex glass-forming liquids: broadening of the glass transition as studied by shear rheology (2017)

Peer reviewed
Phase diagram and dilution experiments in the crystallization of carboxypeptidase G2 (1994)

The automated microbatch technique developed at Imperial College has been used to establish a phase diagram for crystallization. The concentrations of the protein (carboxypeptidase G2) and precipitant (PEG 4000) were varied, while pH and temperature were kept constant. The diagram consists of an undersaturation and a supersaturation zone, the latter being subdivided into the metastable, nucleation and precipitation zones. In the metastable zone, crystals may grow but nucleation of crystals does not occur. It is the best zone for growth of X-ray diffraction quality crystals because of the slower growth rate and the avoidance of uncontrolled nucleation, which uses up protein in the formation of tiny crystals. Nevertheless, in practice, it is rarely well defined or used because nuclei must be introduced artificially into the system. The new method used here consists of setting crystallization droplets at nucleation conditions and later diluting them to conditions where nucleation has not been observed. Single diffracting crystals of typical dimensions 0.3 x 0.3 x 0.2 mm were routinely obtained in the metastable zone, equivalent to the best (very rarely) obtained crystals in the nucleation zone.
An investigation of the effect of an essential oil mouthrinse on induced bacteraemia: a pilot study (2010)

This double-blind, placebo-controlled, randomized, 2-week cross-over study showed that rinsing with essential oils reduced the level of bloodstream bacteria in subjects with mild-to-moderate gingivitis.
Low-power phase-conjugate interferometry (1981)

The operation of Mach-Zehnder and Michelson phase-conjugate interferometers is demonstrated. Phase conjugation is obtained by degenerate four-wave mixing in thin films of eosin. High-visibility fringes are observed both in cw and pulsed modes of operation.
Detection of lecithin: cholesterol acyltransferase (LCAT) in a human hepatoma cell line. (1985)

A human hepatoma cell line (HepG-2) was probed for the presence of lecithin: cholesterol acyltransferase (LCAT) using an antiserum to human plasma LCAT. Double immunodiffusion analysis using antiserum to human plasma LCAT revealed a single precipitin line in the sonicated cell homogenate. This precipitin line showed a reaction of identity with highly purified plasma LCAT. The presence of LCAT within the hepatoma cells was also confirmed by an immunofluorescence test. In contrast, the cell culture supernate showed a weak and inconsistent precipitin line. These data suggest that HepG-2 cells synthesize LCAT but secretion of the enzyme by these cells into the culture medium may be partially or totally impaired.
Ligament Reconstruction with Reference to the Anterior Cruciate Ligament of the Knee (2020)

This chapter concentrates on the reconstruction of knee ligaments with specific reference to the anterior cruciate ligament (ACL). This is because the knee is the joint most vulnerable to ligamentous injuries and the ACL is the most frequently injured. The ACL is attached to the medial side of the intercondylar area of the tibia and the lateral side of the intercondylar notch of the femur. The medial collateral ligament strengthens the medial aspect of the capsule. It is a broad, flat band nearer the back than the front of the joint. It runs from the medial femoral condyle to the medial condyle and surface of the shan of the tibia. Laboratory measurements on various ligaments have been carried out to determine their mechanical properties. Where human ligaments are concerned, more attention has been given to knee ligaments, these being the most vulnerable to injury and most needing reconstruction.
Environmental Problem and Rural Planning (1984)

In this report I will argue what technology and regional planning harmonized with the environment should be, based on a study of environmental problems that I was once concerned with in my position with the research administration. First, I assert that non-physical factors affect environmental problems more than physical factors. In this sense, technology is as important as it ought to be. We should employ the technological innovations that are well-matched with the conservation of the environment and resources, rather than the technologies based solely on economic rationality. I also introduce the plan of the “Agropolice, ” (in which agriculture is the main industry but there are also factories and other urban facilities), and the plan of the regional agriculture system, a closed system which harnesses energy and resorces. The contents are as follows: 1. Meaning of “Widow Erosion” 2. Environmental conservation and technology 3. Timber stealing from wood lots owned by others and mutual social aid 4. Development stages of technological innovations 5. Plan of the “Agropolice” 6. Model of a regional agriculture system 7. Rural planning in the information-oriented age 8. Measurement of the functions of environment
A Novel Web-based Management of Networked Display for Advanced Collaboration Environment (2009)

Not many years ago, people found the contemporary technology expensive and difficult to use in collaborative type of meetings. Today, with the technology advanced to high standards and accessible at cheaper price, its adaption is becoming more and more ubiquitous with wide range of applications. Today’s meeting rooms are not just plain old telephone systems with microphones and speakers. Today’s meeting rooms are smart and intelligent. They can identify the participants; they can provide natural view of remote participants; they can proactively manage resources for collaboration and so on. More effective collaboration is possible with deployment of devices like high-definition cameras, advanced displays, sensors, gigabit networks, trackers, pointers, and high-end audio devices. Devices alone are not enough in the meeting rooms. We need software infrastructure to manage the devices and meeting contexts. One such software infrastructure is SMeet, a Smart Meeting space, which we have developed to provide an effective multi-party remote collaboration environment. Networked display systems are used in such advanced collaboration environment for better visualization. In this paper we discuss a novel approach to control and manage networked display systems in SMeet environment.
Supplementary Table 2 from Chromogranin A Regulates Tumor Self-Seeding and Dissemination (2023)

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Finite Element Analysis on Deformation of Water-Cooled Furnace Door (2013)

The function and failure form of furnace door during the operation of reheating furnace are introduced,the furnace door structure applied in practical production is selected as a research subject,and a geometrical model of furnace door is developed by means of SOLIDWORKS software,the impact by the temperature difference between water-cooled side frame and steel plates and ribs in rear of furnace door on the furnace door deformation is analyzed by means of ANSYS finite element analysis software.The major factors,which should be considered in the design to control and reduce furnace door deformation,are found out through analyzing and comparing the arrangement of the steel plates and ribs in rear of furnace door,the thickness of steel plates in rear of furnace door and the cross-section size of water-cooled side frame.
High performance Fresnel-based photovoltaic concentrator (2010)

In order to achieve competitive system costs in mass-production, it is essential that CPV concentrators incorporate sufficient manufacturing tolerances. This paper presents an advanced concentrator optic comprising a Fresnel lens and a refractive secondary element, both with broken rotational symmetry, an optic producing both the desired light concentration with high tolerance (high acceptance angle) as well as an excellent light homogenization by Köhler integration. This concentrator compares well with conventional Fresnel-based CPV concentrators.
Mathematical model of mean age, mean arsenic dietary dose and age-specific prevalence rate from endemic chronic arsenic poisoning: a human toxicology study. (1980)

The aim of this investigation was to develop a mathematical model of mean age, mean arsenic dietary dose, and age-specific prevalence rate for endemic chronic arsenic poisoning. Data on mean age (years), mean arsenic dietary dose (mg/kg body weight/day), and age-specific prevalence rate per 100,000 population for endemic chronic arsenic poisoning in Antofagasta Commune, northern Chile, for the 1968-1971 period, were collected. Endemic chronic arsenic poisoning means here chronic arsenical dermatosis associated with marked or sever symptoms (or signs) of chronic arsenic poisoning (chronic diarrhoea, hepatic cirrohsis, chronic bronchitis, bronchiectasis, recurrent broncho-pneumonia, cardiomegaly, systemic occlusive arterial disease, cerebral thrombosis, etc.) There was a strong positive correlation between age-specific prevalence rate per 100,000 population and mean arsenic dose (r = + 0.9593) and a negative correlation between prevalence rate and mean age (r = 0.8789). These findings show that the prevalence rate declines with the advancing age and increases with the increase of arsenic dose. A multiple linear regression model E(y) = alpha + beta X1 + gamma X2, where y represents the age-specific prevalence rate per 100,000 population, X1 the mean arsenic dose, and X2 the mean age, was fitted to the data. The estimates of the parameters (alpha, beta, and gamma) were obtained by minimizing the residual sum of squares sigma(y - alpha - beta X1 - gamma X2)2. The following multiple linear regression equation was obtained: Y = 202.161 + 8452.455 X1 - 2.394 X2. Of the total variability in the prevalence rate, 96.22 per cent was accounted for by the multiple regression.