gebhart/patrepeval huggingface dataset:
ChemInform Abstract: STOFFWECHSELPRODUKTE VON MIKROORGANISMEN 98. MITT. PHOSPHINOTHRICIN UND PHOSPHINOTHRICYL‐ALANYL‐ALANIN (1972)

Abstract Aus Kulturen von Streptomyces viridochromogenes wird das neue Antibioticum (I) isoliert.
Design and Performance Analysis of Supercapacitor Charging Circuits for Wireless Sensor Nodes (2011)

Micro-solar energy harvesting systems have achieved efficient operations through maximum power point tracking (MPPT) and maximum power transfer tracking (MPTT) techniques. However, they may have chargers with relatively high power thresholds, below which they have 0% efficiency. As a result, these harvesters either require much larger panels than necessary, or they fail to sustain extended periods of poor weather. To address this problem, we propose to generalize MPTT to MCZT, for Maximum Charging Zone Tracking, to expand the zones of effective charging. To cover the wide dynamic range of solar irradiation, we propose a programmable charge pump driven by a direct digital synthesizer (DDS). In addition, we dynamically reconfigure the topology of multiple supercapacitors to maximize charging efficiency and minimize voltage-dependent leakage. Experimental results from simulation and measurement show that under the high solar irradiance of 1000 W/m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , our MPTT part achieves 40%-50% faster charging time than one without MPTT; and under low solar irradiation of 300 W/m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> , the boost-up operation of our system enables fully charging the supercapacitors, thereby extending the harvesting time zone from 10:00 am-07:10 pm to 8:20 am-8:00 pm even on a sunny day, all with an MPTT overhead of 1.5 mW.
Modulating effect of interleukin 2 therapy on interferon production by blood leukocytes of patients with minimal residual hematological disease. (1997)

This study was designed to investigate the effect of 1.8 x 10(6) U/day interleukin 2 (IL-2) therapy on interferon (IFN) production. Patients enrolled in the study suffered from multiple myeloma (MM), Hodgkin's disease (HD) and non-Hodgkin lymphoma (NHL). All of them were in remission after chemotherapy or radiotherapy. Results indicated that IL-2 given subcutaneously at a dose of 1.8 x 10(6) U/day for 3 weeks induced IFN-gamma in serum of patients and caused a prolonged effect on the ability of blood leukocytes to produce IFN-gamma after stimulation in vitro by mitogen phytohemagglutinin (PHA). Such enhancement of IFN-gamma production may be beneficial for antitumor immune response. Low-dose IL-2 therapy was well tolerated by all patients and side effects not exceeding II grade of toxicity according to WHO scale were observed. Five patients with MM have relapsed 3-10 months after cesation of IL-2 therapy but 15 patients 18 months after therapy were in complete remission.
Leo Szilard (2004)

S INCE retiring as a full-time faculty member about ment of this building. Their plan was to study mutation in bacteria, and they looked for methods
Microfluidic Devices for Behavioral Analysis, Microscopy, and Neuronal Imaging in Caenorhabditis elegans (2015)

Microfluidic devices offer several advantages for C. elegans research, particularly for presenting precise physical and chemical environments, immobilizing animals during imaging, quantifying behavior, and automating screens. However, challenges to their widespread adoption in the field include increased complexity over conventional methods, operational problems (such as clogging, leaks, and bubbles), difficulty in obtaining or fabricating devices, and the need to characterize biological results obtained from new assay formats. Here we describe the preparation and operation of simple, reusable microfluidic devices for quantifying behavioral responses to chemical patterns, and single-use devices to arrange animals for time-lapse microscopy and to measure neuronal activity. We focus on details that eliminate or reduce the frustrations commonly experienced by new users of microfluidic devices.
A Tissue Engineered Model of Aging: Interdependence and Cooperative\n Effects in Failing Tissues (2017)

Aging remains a fundamental open problem in modern biology. Although there\nexist a number of theories on aging on the cellular scale, nearly nothing is\nknown about how microscopic failures cascade to macroscopic failures of\ntissues, organs and ultimately the organism. The goal of this work is to bridge\nmicroscopic cell failure to macroscopic manifestations of aging. We use tissue\nengineered constructs to control the cellular-level damage and cell-cell\ndistance in individual tissues to establish the role of complex interdependence\nand interactions between cells in aging tissues. We found that while\nmicroscopic mechanisms drive aging, the interdependency between cells plays a\nmajor role in tissue death, providing evidence on how cellular aging is\nconnected to its higher systemic consequences.\n
Emergency Bypass Surgery in Impending and Complicated Acute Myocardial Infarction (1972)

Emergency aorto-coronary vein bypass was performed in 20 patients: 11 with impending infarction, two with impending infarction and cardiogenic shock, three with acute infarction and continued angina, and four with acute infarction and cardiogenic shock. Nineteen survived and experienced marked clinical improvement. Left ventricular function was evaluated postoperatively in 12 patients. In six of eight patients with impending infarction, and reduced preoperative values for ejection fraction, segmental wall motion, and contractility, there was great improvement postoperatively. Two patients with impending infarction and cardiogenic shock showed normal left ventricular function postoperatively, but two with acute infarction and cardiogenic shock were left with subnormal left ventricular function.
PZT uniaxial stress dependence: experimental results (1994)

Abstract The main characteristics of a PZT ceramic, such as the piezoelectric charge coefficient or the permittivity, may change drastically when the ceramic undergoes a high uniaxial stress along its polar axis in the 10 to 150 MPa range. A special device has been built to measure accurately and directly the d33 and ϵT 33 parameters of a PZT rod with a superimposed controlled uniaxial stress. Experimental results are proposed showing the uniaxial stress dependence on several PZT samples near the morphotropic phase boundary. These results point out the influence of the Zr/Ti ratio on the uniaxial stress and show that according to a given working stress range, it could be possible to optimize the evolution of the piezoelectric coefficients such as d33 or ϵT 33.
Ring resonator-based single-chip 1x8 optical beam forming network in LPCVD waveguide technology (2006)

Optical ring resonators (ORRs) are good candidates to provide continuously tunable delay in beam forming networks (BFNs) for phased array antenna systems. Delay and splitting/combining elements can be integrated on a single optical chip to form an OBFN. A state-of-the-art 1×8 OBFN chip has been fabricated in LPCVD waveguide technology. It is designed with 1 input and 8 outputs, between which a binary-tree topology is used. A different number of ORRs (up to 7) are cascaded for each output. In this paper, the principle of operation is explained and demonstrated by presenting measurements on the 1×8 OBFN chip.
Relationship between measured and prescribed dialysate sodium in haemodialysis: a systematic review and meta-analysis (2020)

A limited number of studies suggest that, on average, prescribed and measured DNa are similar. However, between- and within-study differences were large. Further consideration of the precision of delivered DNa is required to inform rational prescribing.
Flicker noise fluctuations in deep submicron MOSFETs (2007)

This thesis investigates the effects of technology scaling on the flicker (or \lf) noise performance of deep submicron complementary metal-oxide-semiconductor (CMOS) transistors. Two major effects have been investigated, namely the employment of different gate dielectric growth and subsequent nitridation conditions, and the effects of geometry scaling. The first part of this work focus on the study of these two effects within the 0.25p.m technology node. Subsequently the scope of this study has been widened to examine the effects of scaling across a spectrum of technology nodes, namely 0.35um, 0.25um, 0.18pm and 0.13um. Finally the scope is further extended to cover the offering of different process flavours, as well as geometry scaling for the 0.13pm technology node.
Rodent heart failure models do not reflect the human circulating microRNA signature in heart failure (2017)

The previous observation that miRNAs circulate in lower levels in human patients with heart failure could not be validated in well-established rat and mouse heart failure models. These results question the translation of data on human circulating miRNA levels to experimental models, and vice versa the validity of experimental miRNA data for human heart failure.
Vapor phase epitaxially grown InGaAs photodiodes (1980)

Vapor phase In <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</inf> Ga <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1-x</inf> As photodiodes were fabricated for compositions <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x = 0-0.57</tex> . p <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+</sup> -layers were made by Zn diffusion using ZnAs <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> as a Source. Dark currents at half the breakdown voltage for <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</tex> = 0.15, 0.17, and 0.31 were as low as those fabricated by liquid phase epitaxy. The planar structure is superior to a mesa structure with respect to dark current. Dark currents for various compositions were compared with theoretical estimation. Current multiplications in planar diodes with <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x = 0.31</tex> were about 10 at the junction center and 200-300 at the periphery. Response time to 1.06-µm Nd: YAG mode locked laser pulses was measured to be about 250 ps.
EnGenIUS — ENVIRONMENTAL GENOME INFORMATIONAL UTILITY SYSTEM (2008)

Short-insert shotgun sequencing approaches have been applied in recent years to environmental genomic libraries. In the case of complex multispecies microbial communities, there can be many sequence reads that are not incorporated into assemblies, and thus need to be annotated and accessible as single reads. Most existing annotation systems and genome databases accommodate assembled genomes containing contiguous gene-encoding sequences. Thus, a solution is required that can work effectively with environmental genomic annotation information to facilitate data analysis. The Environmental Genome Informational Utility System (EnGenIUS) is a comprehensive environmental genome (metagenome) research toolset that was specifically designed to accommodate the needs of large (> 250 K sequence reads) environmental genome sequencing efforts. The core EnGenIUS modules consist of a set of UNIX scripts and PHP programs used for data preprocessing, an annotation pipeline with accompanying analysis tools, two entity relational databases, and a graphical user interface. The annotation pipeline has a modular structure and can be customized to best fit input data set properties. The integrated entity relational databases store raw data and annotation analysis results. Access to the underlying databases and services is facilitated through a web-based graphical user interface. Users have the ability to browse, upload, download, and analyze preprocessed data, based on diverse search criteria. The EnGenIUS toolset was successfully tested using the Alvinella pompejana epibiont environmental genome data set, which comprises more than 300 K sequence reads. A fully browsable EnGenIUS portal is available at (http://ocean.dbi.udel.edu/) (access code: "guest"). The scope of this paper covers the implementation details and technical aspects of the EnGenIUS toolset.
Customer control of intelligent network services (2003)

The authors describe the evolution of network services customer control, concentrating on the impact that the intelligent network (IN) is exerting on the customer control telecommunications phenomenon. They trace the evolution of the methods of control over network services from the original telephone company operators through modern sophisticated terminal interactions with the IN. They also examine the nature of the control structures, detailing the advances that are occurring as customers control not only the parameters associated with a service, but also the very operation of the service itself. They also contrast the changing nature of local control structures and distributed control architectures. They indicate at the next layer of customer control that could develop in the 1990s and beyond.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Fast Forward Selection to Speed Up Sparse Gaussian Process Regression (2003)

We present a method for the sparse greedy approximation of Bayesian Gaussian process regression, featuring a novel heuristic for very fast forward selection motivated by active learning. We show how a large number of hyperparameters can be adjusted automatically by maximizing the marginal likelihood of the training data. Our method is essentially as fast as an equivalent one which selects the &amp;quot;support&amp;quot; patterns at random, yet has the potential to outperform random selection on hard curve fitting tasks and at the very least leads to a more stable behaviour of first-level inference which makes the subsequent gradient-based optimization of hyperparameters much easier. In line with the development of our method, we present a simple view on sparse approximations for GP models and their underlying assumptions and show relations to other methods.
Packet power dynamic range management in optical packet ring networks (2008)

This paper analyses the impact of packet power variations in optical packet ring networks, and demonstrates the need for a distributed power equalisation to guarantee the quality of signal for each packet.
Speaker tracking in a broadcast news corpus. (2001)

Speaker tracking is the process of following who says something in an audio stream. In the case the audio stream is a recording of broadcast news, speaker identity can be an important meta-data for building digital libraries. Moreover, the segmentation and classification of the audio stream in terms of acoustic contents, bandwidth and speaker gender allow to filter out portions of the signal which do not contain speech and to improve transcription accuracy through the use of condition-dependent acoustic models and adaptation techniques.
An Extension to Session Initiation Protocol (SIP) Events for Conditional Event Notification (2010)

The Session Initiation Protocol (SIP) events framework enables receiving asynchronous notification of various events from other SIP user agents. This framework defines the procedures for creating, refreshing, and terminating subscriptions, as well as fetching and periodic polling of resource state. These procedures provide no tools to avoid replaying event notifications that have already been received by a user agent. This memo defines an extension to SIP events that allows the subscriber to condition the subscription request to whether the state has changed since the previous notification was received. When such a condition is true, either the body of a resulting event notification or the entire notification message is suppressed.
Floating-disk parylene microvalve for self-regulating biomedical flow controls (2008)

A novel self-regulating parylene microvalve is presented in this paper with potential applications for biomedical flow controls. Featuring a free-floating bendable valve disk and two-level valve seat, this surface-micromachined polymeric valve accomplishes miniature pressure/flow rate regulation in a band-pass profile stand-alone without the need of power sources or active actuation. Experimental data of underwater testing results have successfully demonstrated that the microfabricated in-channel valve can regulate water flow at 0–80 mmHg and 0–10 μL/min pressure/flow rate level, which is perfectly suitable for biomedical and lab-on-a-chip applications. For example, such biocompatible microvalve can be incorporated in ocular implants for control of eye fluid drainage to fulfill intraocular pressure (IOP) regulation in glaucoma patients.
Transcriptional regulation of the mitochondrial genome of yeast Saccharomyces cerevisiae. (1986)

The relative rates of transcription of several classes of the mitochondrial genes of the yeast Saccharomyces cerevisiae have been determined. The rates were measured by pulse labeling whole yeast with [32P]O4, isolating the total RNA, hybridization to single-stranded M13 DNA probes containing segments of the gene of interest, digestion with RNase A or T1, and separation of the protected fragment by gel electrophoresis. This analysis indicated that, among the genes analyzed, transcriptional promoters varied in strength by 20-fold while the rates of transcription varied by more than 50-fold. The strengths of the promoters of the genes were ordered: tRNAMetf greater than tRNAPhe greater than 14 S rRNA greater than 21 S rRNA greater than tRNAGlu greater than Oli-1 much greater than tRNACys. In addition, transcription rates were measured within polygenic transcription units. This analysis indicated that there was transcriptional attenuation within all the polygenic transcription units with the greatest attenuation factor being as much as 17-fold, occurring after the tRNAGlu and tRNAMetf genes. This analysis indicated that regulation of the rates of transcription in the yeast mitochondrial genome occurs by two distinct mechanisms, modulation of the rate of transcriptional initiation and attenuation of transcriptional elongation.
Suppression and Replacement Gene Therapy for KCNH2 -Mediated Arrhythmias (2022)

We provide the first proof-of-principle gene therapy for correction of both LQT2 and SQT1. KCNH2-SupRep gene therapy successfully normalized the pathologic APD<sub>90</sub>, thereby eliminating the pathognomonic feature of both LQT2 and SQT1.
Inhibition of Ca2+ channel current by μ‐ and κ‐opioid receptors coexpressed in Xenopus oocytes: desensitization dependence on Ca2+ channel α1 subunits (1997)

1. Desensitization of mu- and kappa-opioid receptor-mediated inhibition of voltage-dependent Ca2+ channels was studied in a Xenopus oocyte translation system. 2. In the oocytes coexpressing kappa-opioid receptors with N- or Q-type Ca2+ channel alpha 1 and beta subunits, the kappa-agonist, U50488H, inhibited both neuronal Ca2+ channel current responses in a pertussis toxin-sensitive manner and the inhibition was reduced by prolonged agonist exposure. 3. More than 10 min was required to halve the inhibition of Q-type channels by the kappa-agonist. However, the half-life for the inhibition of N-type channels was only 6 +/- 1 min. In addition, in the oocytes coexpressing mu-opioid receptors with N-type or Q-type channels, the uncoupling rate of the mu-receptor-mediated inhibition of N-channels was also faster than that of Q-type channels. 4. In the oocytes coexpressing both mu- and kappa-receptors with N-type channels, stimulation of either receptor resulted in a cross-desensitization of the subsequent response to the other agonist. Treatment of oocytes with either H-8 (100 microM), staurosporine (400 nM), okadaic acid (200 nM), phorbol myristate acetate (5 nM) or forskolin (50 microM) plus phosphodiesterase inhibitor did not affect either the desensitization or the agonist-evoked inhibition of Ca2+ channels. 5. These results suggest that the rate of rapid desensitization is dependent on the alpha 1 subtype of the neuronal Ca2+ channel, and that a common phosphorylation-independent mechanism underlies the heterologous desensitization between opioid receptor subtypes.
Characterization of a ripening-related transcription factor FcNAC1 from Fragaria chiloensis fruit (2018)

Fragaria chiloensis is a strawberry endemic from Chile with attractive white-pink fruit, pleasant aroma and taste. However, this fruit has a limited post-harvest period due to fast softening. Several transcription factors (TFs) are involved in the regulation of fruit ripening, and members of the NAC family have been implicated in cell wall remodeling. FcNAC1 was isolated from F. chiloensis fruit, coding a protein of 332 amino acid residues and displaying a characteristic NAC domain at the N terminus. FcNAC1 protein showed nuclear localization. An increase in transcript level was observed during ripening. A sequence of 1488 bp of FcNAC1 promoter was obtained. In silico analysis identified cis elements able to respond to some hormones and Secondary wall NAC binding elements (SNBE), and responding to auxin and ABA. A structural model of FcNAC1 provided evidence for interaction with DNA sequences containing SNBE, while a dual luciferase assay confirmed the transcriptional activation by FcNAC1 of the promoter of FcPL, a gene involved in cell wall remodeling in F. chiloensis fruit. The results suggest the participation of FcNAC1 during ripening development of strawberry fruit, by regulating pectin metabolism during softening.
T1- and T*2-Dominant Extravasation Correction in DSC-MRI: Part I—Theoretical Considerations and Implications for Assessment of Tumor Hemodynamic Properties (2011)

We present a novel contrast agent (CA) extravasation-correction method based on analysis of the tissue residue function for assessment of multiple hemodynamic parameters. The method enables semiquantitative determination of the transfer constant and can be used to distinguish between T(1)- and T(2)(*)-dominant extravasation effects, while being insensitive to variations in tissue mean transit time (MTT). Results in 101 patients with confirmed glioma suggest that leakage-corrected absolute cerebral blood volume (CBV) values obtained with the proposed method provide improved overall survival prediction compared with normalized CBV values combined with an established leakage-correction method. Using a standard gradient-echo echo-planar imaging sequence, ∼60% and 10% of tumors with detectable CA extravasation mainly exhibited T(1)- and T(2)(*)-dominant leakage effects, respectively. The remaining 30% of leaky tumors had mixed T(1)- and T(2)(*)-dominant effects. Using an MTT-sensitive correction method, our results show that CBV is underestimated when tumor MTT is significantly longer than MTT in the reference tissue. Furthermore, results from our simulations suggest that the relative contribution of T(1)- versus T(2)(*)-dominant extravasation effects is strongly dependent on the effective transverse relaxivity in the extravascular space and may thus be a potential marker for cellular integrity and tissue structure.