gebhart/patrepeval huggingface dataset:
Unexpected resilience to experimental gingivitis of subepithelial connective tissue grafts in gingival recession defects: a clinical–molecular evaluation (2013)

Analysis of the data demonstrates that the sites of gingival recession treated with SCTG develop a lower degree of plaque-induced inflammation compared to healthy gingivae. This strongly suggests that SCTG does not predispose to inflammation and to further gingival recession and makes it a safe technique in the treatment of gingival defects.
Reaction of Harmidine/Harmaline with BrCN — a Facile Mono- and Di-Bromination at a-Carbon of the Imine Tautomer (1985)

Abstract Reaction of harmidine/harmaline with BrCN has afforded mono- and di-bromo derivatives I and II respectively indicating the substitution of bromine at the α-carbon of imine through its enamine tautomer
Cochlear implant fitting based on automated measurements of the electrically evoked compound action potential (2019)

The clinical fitting procedures of cochlear implants (CIs) have mainly been based on subjective feedback. However, this can be difficult and time-consuming for CI recipients who are not able to give appropriate feedback concerning loudness perception during stimulation (e.g. children). Therefore, objective measures like electrically evoked action potentials (ECAP) have been used to assist fitting. The MED-EL system software MAESTRO 7 offers an automatic method named ARTFit which is based on ECAP-measures with the new Fine-grain-Method (Gärtner et al. 2018, BioMed Eng OnLine 17:140).
Chemoprevention of Head and Neck Cancer With Aspirin (2006)

Aspirin use is associated with reduced risk of head and neck cancer. This effect is more pronounced in individuals with low to moderate exposure to cigarette smoke or alcohol consumption.
P67 * DEFINING A TARGET INTRA-CEREBROSPINAL FLUID STEADY STATE ETOPOSIDE CONCENTRATION [CSF ETOPOSIDE] FOR PHASE I STUDY IN CHILDREN WITH LEPTOMENINGEAL METASTASIS (LM): INTREPID, A FIRST IN MAN STUDY (2014)

INTRODUCTION: Continuous intra-CSF etoposide infusion may optimise etoposide pharmacokinetics by bypassing the blood-brain-barrier and compensating for CSF bulk flow removal, at < 1/340th dose of standard regimens. A 3 + 3 phase I study is proposed, escalating target [CSF etoposide] and infusion durations of intra-CSF etoposide in children with LM. We justify target [CSF etoposide] and infusion durations based upon previously reported clinical and our own preclinical studies. METHOD: AUC24 values were calculated from Fleischhack report of 24 patients receiving intra-ventricular etoposide at 0.25 mg/12h, 0.5 mg/24h or 1 mg/24h, for 5 days, q 2-4 wks (n = 119 cycles), no dose limiting toxicity was reported. The AUC24 values derived from these clinical studies were compared to etoposide cytotoxicity data in human tumour and neural stem cell 3D co-cultures. AUC values were selected to derive target [CSF etoposide], levels 1 & 2 for infusion durations of 7, 10 and 14 days: AUC24= [CSF etoposide] x time (h). RESULTS: Based upon 0.25 mg/12h dose level, the AUC24 25 µg x h/ml (level 1) predicted [CSF etoposide] 1 µg/ml over 24 hours and an AUC7day of 175 µg x h/ml. The cytotoxicity assay [etoposide] of 0.8-1.2 µg/ml resulted in 22% neural stem cell and 8% tumour cell viability, illustrating differential toxicity. Level 1[CSF etoposide] was selected as 0.8 µg/ml as equivalent of AUC24 20, for 7 days (AUC7day 140). Level 2 [CSF etoposide] of 1.2 µg/ml was selected, (AUC7day 210, AUC10days 300; AUC14day 420). CONCLUSION: Target [CSF etoposide] will be 0.8 µg/ml (level 1) to 1.2 µg/ml (level 2), with infusion durations of 7, 10 or 14 day.
Emergent marine toxins risk assessment using molecular and chemical approaches (2022)

Abstract Cyanobacteria harmful blooms represent a deviation to the normal equilibrium in planktonic communities involving a rapid and uncontrolled growth. Owing to the capacity to produce toxins as secondary metabolites, cyanobacteria may cause huge economic losses in the fishing and aquaculture industries and poisoning incidents to humans due to their accumulation in the food chain. The conditions which promote toxic blooms have not yet been fully understood, but climate change and anthropogenic intervention are pointed as significant factors. For the detection of toxins in edible marine organisms, the establishment of international regulations and compulsory surveillance has been probed as exceptionally effective. However, not regulation nor monitoring have been settled concerning emergent marine toxins. In the light of this scenario, it becomes essential to apply fast and reliable surveillance methodologies for the early detection of cyanobacterial blooms as well as the occurrence of emergent marine toxins. Shotgun metagenomic sequencing has potential to become a powerful diagnostic tool in the fields of food safety and One Health surveillance. This culture‐independent approach overcomes limitations of traditional microbiological techniques; it allows a quick and accurate assessment of a complex microbial community, including quantitative identification and functional characterisation, in a single experiment. In the framework of the EU‐FORA fellowship, with the final goal of evaluate metagenomics as a promising risk assessment tool, the fellow worked on the development of an innovative workflow through state‐of‐the‐art molecular and chemical analytical procedures. This work programme aims to evaluate the occurrence of emergent marine toxins and the producing organisms in Cabo Verde coastal cyanobacteria blooms. Our results show the outstanding potential of a holistic metagenomic approach for the risk assessment of emergent marine toxins and the producing organisms. Additionally, we have also highlighted its value for the identification and evaluation of secondary metabolites as natural bioactive compounds with biotechnological and industrial interest.
Effectiveness of Clinical Pharmacist Service on Drug-Related Problems and Patient Outcomes for Hospitalized Patients with Chronic Kidney Disease: A Randomized Controlled Trial (2021)

(1) Background: The study aimed to analyze the effectiveness of clinical pharmacist services on drug-related problems (DRPs) and patient outcomes in inpatients with chronic kidney disease (CKD). (2) Methods: In a randomized controlled trial, the participants in the intervention group received pharmacist services, including medication reconciliation, medication evaluation and management, and discharge pharmaceutical care transition services. Participants in the control group received usual care. The primary outcome was the number of DRPs per patient at discharge. (3) Results: The baseline characteristics of 100 participants included the following: mean age, 52.5 years; median eGFR, 9.2 mL/min/1.73 m<sup>2</sup>. The number of DRPs in the intervention group during hospitalization increased significantly with decreasing eGFR (PR, 0.970; 95% CI, 0.951-0.989) and an increasing number of unintentional medication discrepancies at admission (PR, 1.294; 95% CI, 1.034-1.620). At discharge, the number of DRPs per patient was 0.94 ± 1.03 and 1.96 ± 1.25 in the intervention and control groups, respectively (<i>p</i> < 0.001). The service had a significant effect on the reduction of the unintentional discrepancies at discharge (<i>p</i> < 0.001). (4) Conclusion: Hospital pharmacists play an important role in the prevention of DRPs at discharge and unintentional medication discrepancies in inpatients with CKD.
Obesity and asthma, what are the links? (2005)

There is evidence that obesity and overweight are associated with the development of asthma. Yet, the mechanisms underlying this relation are unclear. Weight reduction among asthmatic patients can result in improvements of lung function demonstrating the potential clinical impact of the findings.
P-Selectin Glycoprotein Ligand-1 as a Potential Target for Humoral Immunotherapy of Multiple Myeloma (Supplementry Material) (2009)

Monoclonal antibodies (mAbs), successfully adopted in the treatment of several haematological malignancies, have proved almost ineffective in multiple myeloma (MM), because of the lack of an appropriate antigen for targeting and killing MM cells. Here, we demonstrate that PSGL1, the major ligand of P-Selectin, a marker of plasmacytic differentiation expressed at high levels on normal and neoplastic plasma cells, may represent a novel target for mAb-mediated MM immunotherapy. The primary effectors of mAb-induced cell-death, complement-mediated lysis (CDC) and antibody-dependent cellmediated cytotoxicity (ADCC), were investigated using U266B1 and LP1 cell-lines as models. Along with immunological mechanisms, the induction of apoptosis by PSGL1 cross-linking was assessed. The anti-PSGL1 murine mAb KPL1 induced death of MM cells in a dose- and time-dependent fashion and mediated a significant amount of ADCC. KPL1 alone mediated C1q deposition on target cells but proved unable to induce CDC due to inhibition of the lytic activity of complement by membrane complement regulators (mCRP) expressed on the cell surface. Consistently, CDC was induced by KPL1 upon mCRP blockage. Our results suggest a role for PSGL1 in MM humoral immunotherapy and support further in vivo studies assessing the effects of anti-PSGL1 mAbs on MM growth and interaction with the bone marrow microenvironment. Keywords: PSGL-1, multiple myeloma, immunotherapy, monoclonal antibodies, ADCC, complement
Human Leukocyte Migration Inhibition in Agarose Using Four Antigens: Correlation with Skin Reactivity (1973)

Summary A technique is described for the in vitro evaluation of human cellular immunity by determining the inhibition of the migration of peripheral buffy coat leukocytes in agarose plates after incubation of the cells with and without antigens. The technique is simple to perform and results can be obtained in 18 hr. With three antigens (Candida, PPD and SK-SD), the results correlated well with skin reactivity in normal subjects.
Accelerating Polynomial Multiplication for Homomorphic Encryption on GPUs (2022)

Homomorphic Encryption (HE) enables users to securely outsource both the storage and computation of sensitive data to untrusted servers. Not only does HE offer an attractive solution for security in cloud systems, but lattice-based HE systems are also believed to be resistant to attacks by quantum computers. However, current HE implementations suffer from prohibitively high latency. For lattice-based HE to become viable for real-world systems, it is necessary for the key bottlenecks - particularly polynomial multiplication - to be highly efficient. In this paper, we present a characterization of GPU-based implementations of polynomial multiplication. We begin with a survey of modular reduction techniques and analyze several variants of the widely-used Barrett modular reduction algorithm. We then propose a modular reduction variant optimized for 64-bit integer words on the GPU, obtaining a 1.8x speedup over the existing comparable implementations. Next, we explore the following GPU-specific improvements for polynomial multiplication targeted at optimizing latency and throughput: 1) We present a 2D mixed-radix, multi-block implementation of NTT that results in a 1.85x average speedup over the previous state-of-the-art. 2) We explore shared memory optimizations aimed at reducing redundant memory accesses, further improving speedups by 1.2x. 3) Finally, we fuse the Hadamard product with neighboring stages of the NTT, reducing the twiddle factor memory footprint by 50%. By combining our NTT optimizations, we achieve an overall speedup of 123.13x and 2.37x over the previous state-of-the-art CPU and GPU implementations of NTT kernels, respectively.
Temperature Dependences of the Rheological Properties of “Viscous Paraffin Oil–Aqueous Phase–Surfactant” Systems (2020)

By means of vibrational and rotational viscometry, the possibility has been explored to control the rheological properties of heterogeneous systems “viscous paraffin oil–aqueous phase–surfactant” using compositions based on surfactants and alkaline buffer solutions capable of preserving for a long time in a reservoir a set of colloidal-chemical properties optimal for oil displacement. The depressant ability of nonionic surfactants—oxyethylated alkylphenols with various degrees of oxyethylation from 12 to 90 oxyethyl groups in a molecule—with respect to paraffin waxes has been studied, which makes it possible to increase the mobility and lower the pour point of crude oil. The pour-point depressant ability of nonionic and anionic surfactant formulations that are compatible with mineralized reservoir water of oil fields and stable over a wide range of reservoir temperatures has also been studied.
ChemInform Abstract: Construction of 5,6‐Ring‐Fused 2‐Pyridones: An Effective Annulation Tactic Achieved in Water. (2010)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Continuous flow chemistry: a discovery tool for new chemical reactivity patterns (2014)

Continuous flow chemistry as a process intensification tool is well known. However, its ability to enable chemists to perform reactions which are not possible in batch is less well studied or understood. Here we present an example, where a new reactivity pattern and extended reaction scope has been achieved by transferring a reaction from batch mode to flow. This new reactivity can be explained by suppressing back mixing and precise control of temperature in a flow reactor set up.
Supplemental Figure 1 from Novel Methylated DNA Markers in the Surveillance of Colorectal Cancer Recurrence (2023)

&lt;p&gt;Supplemental Figure 1: The average level of all MDMs assayed from DNA extracted from primary and metastatic CRC tissues was not significantly different in Primary and Metastatic Tissue MDM Concordance Study. (A) Average level of all MDMs in metachronous metastatic CRC and the corresponding primary CRC as well as in synchronous metastatic CRC and the corresponding primary CRC; (B) The difference of average level of all MDMs in paired primary and metachronous metastatic CRC as well as in paired primary and synchronous metastatic CRC. MDM: methylated DNA marker; CRC: colorectal cancer.&lt;/p&gt;
Author response: Chromatin is an ancient innovation conserved between Archaea and Eukarya (2012)

Similarities in the way that nucleosomes are organized into chromatin in archaea and eukaryotes suggest that chromatin might have been involved in gene regulation before its role in DNA packaging evolved.
Electrical, structural, and chemical properties of HfO2 films formed by electron beam evaporation (2008)

High dielectric constant hafnium oxide films were formed by electron beam (e-beam) evaporation on HF last terminated silicon (100) wafers. We report on the influence of low energy argon plasma (∼70 eV) and oxygen flow rate on the electrical, chemical, and structural properties of metal-insulator-silicon structures incorporating these e-beam deposited HfO2 films. The use of the film-densifying low energy argon plasma during the deposition results in an increase in the equivalent oxide thickness (EOT) values. We employ high resolution transmission electron microscopy (HRTEM), x-ray photoelectron spectroscopy (XPS), and medium energy ion scattering experiments to investigate and understand the mechanisms leading to the EOT increase. We demonstrate very good agreement between the interfacial silicon oxide thicknesses derived independently from XPS and HRTEM measurements. We find that the e-beam evaporation technique enabled us to control the SiOx interfacial layer thickness down to ∼6 Å. Very low leakage current density (&amp;lt;10−4 A/cm2) is measured at flatband voltage +1 V into accumulation for an estimated EOT of 10.9±0.1 Å. Based on a combined HRTEM and capacitance-voltage (CV) analysis, employing a quantum-mechanical CV fitting procedure, we determine the dielectric constant (k) of HfO2 films, and associated interfacial SiOx layers, formed under various processing conditions. The k values are found to be 21.2 for HfO2 and 6.3 for the thinnest (∼6 Å) SiOx interfacial layer. The cross-wafer variations in the physical and electrical properties of the HfO2 films are presented.
Matrix metalloproteinase‐7 triggers the matricrine action of insulin‐like growth factor‐II via proteinase activity on insulin‐like growth factor binding protein 2 in the extracellular matrix (2007)

Many growth factors and cytokines are immobilized on the extracellular matrix (ECM) by binding to glycosaminoglycans and are stored in an inactive form in the cellular microenvironment. However, the mechanisms of ECM-bound growth factor or cytokine activation have not been well documented. We showed that the insulin-like growth factor type-1 receptor (IGF-1R) was rapidly phosphorylated after the addition of matrix metalloproteinase (MMP)-7 to a serum-starved human colon cancer cell line (HT29) and that phosphorylation was completely inhibited by an IGF-II neutralizing antibody. In the ECM of this cell line, IGF-II and IGF binding protein (BP)-2 coexisted, but IGFBP-2 disappeared from the ECM fraction after treatment with MMP-7 or heparinase III. On the other hand, in a cell line in which IGF-1R was overexpressed, IGF-1R was phosphorylated by supernatant from the MMP-7-treated ECM fraction of HT29 but not by that from a heparinase-III-treated ECM fraction. We also demonstrated that MMP-7 degrades IGFBP-2 in vitro at three cleavage sites (peptide bonds E(151)-L(152), G(175)-L(176) and K(181)-L(182)), which have not been documented previously. Taken together, these results demonstrate that MMP-7 generates bioactive IGF-II by degrading the IGF-II/IGFBP-2 complex binding to heparan sulfate proteoglycan in the ECM, resulting in IGF-II-induced signal transduction. This evidence indicates that some ECM-associated growth factors enhance their ability to bind to their receptors by some proteases in the tumor microenvironment. This mechanism of action ('protease-triggered matricrine') represents an attractive model for understanding ECM-tumor interactions.
Antireflective Transparent Oleophobic Surfaces by Noninteracting Cavities (2018)

Oleophobic surfaces have been so far realized using complex microscale and nanoscale re-entrant geometries, where primary and secondary structures or overhang geometries are typically required. Here, we propose a new design to create them with noninteracting cavities. The suspension of liquid droplets relies on the mechanism of compression of air under the meniscus leading to stable composite oil-air-solid interfaces. To demonstrate the concept, we make oleophobic surfaces, with contact angle for oleic acid of about 130° (and hexadecane about 110°), using both microholes in silicon and nanoholes in glass. Thanks to the subwavelength dimensions and antireflection effect of the nanoholes, the glass substrate also shows a high degree of optical transparency with optical transmission exceeding that of the initial bare substrate. Crockmeter tests without any significant change in morphology, optical and wetting properties after more than 500 passes also confirm the high mechanical durability of the nanohole surface. The results indicate the possibility of using the proposed oleophobic surfaces for a wide range of applications, including self-cleaning transparent windows and windshields for automobiles and aircrafts.
Line widths, sensitivity and artifacts in 33S NMR Spectra: The case of aqueous sulphides (1986)

Abstract The factors giving rise to artifacts in the NMR spectra of 33 S and other quadrupolar nuclei of low magnetogyric ratio are examined and some tests for their detection are proposed. The effects of line width and probe ring‐down time on the observed signal intensity are considered and a quantitative relationship is described. Sulphur‐33 NMR spectra of sodium sulphide solutions are reported which differ substantially from those recently published. The reasons for these and other differences between reported spectra are explained in terms of experimental artifacts of the types described.
Mechanism of alternating copolymerization of methyl methacrylate with styrene in the presence of diethylaluminum chloride (1982)

Abstract A kinetic study of the propagation mechanism of the alternating copolymerization of styrene (St) with methyl methacrylate (MMA) in the presence of a complexing agent (diethylaluminum chloride, DEAC) in bulk and in tetrachloroethylene solutions at a molar ratio DEAC/MMA = 0.5 has been carried out. It has been shown that the copolymerization is a chain radical process characterized by a short active‐center lifetime, bimolecular termination, and high rate of chain transfer to the complexed MMA. A kinetic scheme has been proposed for the propagation mechanism of alternating copolymerization in the presence of a complexing agent not requiring independent measurements of the equilibrium constant of complexation. It has been found that spontaneous and UV‐initiated copolymerizations in the system have different mechanisms of initiation and a common mechanism of propagation. The propagation proceeds by addition of single monomers as well as donor‐acceptor complexes of the comonomers to the propagation radicals, with the first mechanism being predominant. Inclusion of the monomers in the complex leads to an increase of the St reactivity and to a decrease of the MMA reactivity in propagation to the corresponding macroradicals in comparison with the reactivity of the free monomers. A number of kinetic and statistical parameters of the propagation reaction have been calculated.
Induction of 2,3-aryl migrations in 3-bromoflavanones (1976)

A. Pelter, R. S. Ward and M. Balasubramanian, J. Chem. Soc., Chem. Commun., 1976, 151 DOI: 10.1039/C39760000151
Exchange bias relaxation in reverse magnetic fields (2007)

The time dependence associated with the so-called exchange bias in coupled polycrystalline ferromagnetic/antiferromagnetic films has been suspected as arising from antiferromagnetic domain dynamics. In this paper we present a quantitative description of the nucleation and growth of antiferromagnetic domains based on the Kolmogorov-Avrami model, which describes the time dependence of the exchange bias in all the systems for which data could be found.
Measuring of Methanol Diffusion Coefficients of New Lignin-based Membranes and Nafion 117 Du Pont Membranes (2006)

Abstract not Available.