gebhart/patrepeval huggingface dataset:
Combined SEU and SEFI Protection for Memories Using Orthogonal Latin Square Codes (2016)

Radiation effects cause several types of errors on memories including single event upsets (SEUs) or single event functional interrupts (SEFIs). Error correction codes (ECCs) are widely used to protect against those errors. For a number of reasons, there is a large interest in using double data rate type three (DDR-3) synchronous dynamic random-access (SDRAM) memories in space applications. Radiation testing results show that these memories will suffer both SEUs and SEFIs when used in space. Protection against a SEFI and an SEU is needed to achieve high reliability. In this paper, a method to protect 16-bit and 64-bit data word memories composed of 8-bit memory devices against a simultaneous SEFI and an SEU is presented. The scheme uses orthogonal Latin square (OLS) codes and can be activated when a SEFI occurs, using a conventional double error correction approach otherwise.
Development of 1.8 K helium refrigeration system for CERN (2005)

The Conseil Europeen pour la Recherche Nucleaire ( CERN ) placed an order for a 1.8 K helium refrigeration system with IHI for the Large Hadron Collider project in 1999. IHI formed a consortium with Linde Kryotechnik AG (Switzerland ), which has long experience with helium refrigeration systems. IHI designed and manufactured cold compressors based on leading technologies and expertise for turbo machinery. The cold compressor has the highest efficiency in the world. This paper describes the 1.8 K helium refrigeration system and performance test results at CERN.
On the Mechanism of Drug Release from Polysaccharide Hydrogels Cross-Linked with Magnetite Nanoparticles by Applying Alternating Magnetic Fields: the Case of DOXO Delivery (2015)

The chemical, biological and physical properties of carboxymethylcellulose (CMC) hydrogels with silanized magnetite (Fe₃O₄) nanoparticles (NPs) as cross-linker were investigated and compared with the analogous hydrogel obtained by using 1,3-diaminopropane (DAP) as cross-linker. The magnetic hydrogel was characterized from the chemical point of view by FT-IR, whereas the morphology of the hydrogel was investigated by FESEM and STEM. The water uptake and rheological measurements reveal how much the swelling and mechanical properties change when CMC is cross-linked with silanized magnetite NPs instead of with DAP. As far as the biological properties, the hybrid hydrogel neither exerts any adverse effect nor any alteration on the cells. The magnetic hydrogels show magnetic hysteresis at 2.5 K as well as at 300 K. Magnetic measurements show that the saturation magnetization, remanent magnetization and coercive field of the NPs are not influenced significantly by the silanization treatment. The magnetic hydrogel was tested as controlled drug delivery system. The release of DOXO from the hydrogel is significantly enhanced by exposing it to an alternating magnetic field. Under our experimental conditions (2 mT and 40 kHz), no temperature increase of the hydrogel was measured, testifying that the mechanism for the enhancement of drug release under the AMF involves the twisting of the polymeric chains. A static magnetic field (0.5 T) does not influence the drug release from the hydrogel, compared with that without magnetic field.
Correlation between numerical predictions and measurements of single-mode fiber dispersion characteristics (1980)

Exact numerical solutions for the LP(01) propagating mode of the scalar wave equation are used to calculate propagation constants in single-mode fibers with arbitrary refractive-index profiles. The procedure is used to correlate predicted chromatic dispersion properties of single-mode fibers based on interferometrically measured profiles with direct transmission measurements vs wavelength. Resulting waveguide dispersion effects are used to design single-mode fibers that have minimum chromatic dispersion at desired wavelengths within the 1.3-1.6-microm region.
A Tandem Carbanion Addition/Carbon—Carbon Bond Cleavage Yields Alkynyl Ketones. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
The Ciliary Rootlet Maintains Long-Term Stability of Sensory Cilia (2005)

The striated ciliary rootlet is a prominent cytoskeleton originating from basal bodies of ciliated cells. Although a familiar structure in cell biology, its function has remained unresolved. In this study, we carried out targeted disruption in mice of the gene for rootletin, a component of the rootlet. In the mutant, ciliated cells are devoid of rootlets. Phototransduction and ciliary beating in sensory and motile cilia initially exhibit no apparent functional deficits. However, photoreceptors degenerate over time, and mutant lungs appear prone to pathological changes consistent with insufficient mucociliary clearance. Further analyses revealed a striking fragility at the ciliary base in photoreceptors lacking rootlets. In vitro assays suggest that the rootlet is among the least dynamic of all cytoskeletons and interacts with actin filaments. Thus, a primary function of the rootlet is to provide structural support for the cilium. Inasmuch as photoreceptors elaborate an exceptionally enlarged sensory cilium, they are especially dependent on the rootlet for structural integrity and long-term survival.
Intramolecular cross-coupling of gem-dibromoolefins: a mild approach to 2-bromo benzofused heterocycles (2009)

Highly useful halogenated benzofurans and benzothiophenes are prepared from readily available gem-dibromoolefins using a mild, ligand-free copper catalyzed cross-coupling procedure.
Spatial simulation of instability control by periodic suction blowing (1991)

The applicability of active control by periodic suction blowing in spatially evolving plane Poiseuille flow is investigated by the direct simulation of the three-dimensional, incompressible Navier–Stokes equations. The results reveal that significant reductions in perturbation amplitudes can be obtained by a proper choice of the control wave amplitude and phase. The upstream influence of the control wave is shown to be confined to a region in the vicinity of the control slot with no apparent effect on the flow development.
Part XVIII: Influence of intra‐aortic ballon counterpulsation and collateral flow reversal during multivessel angioplasty (1995)

Flow velocity changes during multivessel angioplasty suggests that collateral flow has an important role in determining safety and ischemic threshold during these procedures. The physiology of collateral flow with and without intra-aortic balloon pumping has been demonstrated in this individual and provides insight into the mechanisms of reduced ischemia during high-risk coronary interventions.
Two‐partner secretion in Gram‐negative bacteria: a thrifty, specific pathway for large virulence proteins (2001)

A collection of large virulence exoproteins, including Ca2+-independent cytolysins, an iron acquisition protein and several adhesins, are secreted by the two-partner secretion (TPS) pathway in various Gram-negative bacteria. The hallmarks of the TPS pathway are the presence of an N-proximal module called the 'secretion domain' in the exoproteins that we have named the TpsA family, and the channel-forming beta-barrel transporter proteins we refer to as the TpsB family. The genes for cognate exoprotein and transporter protein are usually organized in an operon. Specific secretion signals are present in a highly conserved region of the secretion domain of TpsAs. TpsBs probably serve as specific receptors of the TpsA secretion signals and as channels for the translocation of the exoproteins across the outer membrane. A subfamily of transporters also mediates activation of their cognate cytolysins upon secretion. The exoproteins are synthesized as precursors with an N-terminal cleavable signal peptide, and a subset of them carries an extended signal peptide of unknown function. According to our current model, the exoproteins are probably translocated across the cytoplasmic membrane in a Sec-dependent fashion, and their signal peptide is probably processed by a LepB-type signal peptidase. The N-proximal secretion domain directs the exoproteins towards their transporters early, so that translocation across both membranes is coupled. The exoproteins transit through the periplasm in an extended conformation and fold progressively at the cell surface before eventually being released into the extracellular milieu. Several adhesins also undergo extensive proteolytic processing upon secretion. The genes of many new TpsAs and TpsBs are found in recently sequenced genomes, suggesting that the TPS pathway is widespread.
Planetary Soil Impact Dataset (PALPATE) - Dataset (2018)

The Planetary Soil Impact Dataset (PALPATE) is a dataset recorded to demonstrate the applicability of machine learning methods to classify the complex feet-soil interaction on fine-grained soils. The dataset consists of 2600 feet-soil impacts, which were automatically executed and recorded with a specially designed testbed. Impacts were performed on a variety of Martian soil simulants, such as ES-1, ES-2, ES-3 and other. The dataset includes the sensor signals acquired by two different feet and sensors on the testbed. Additionally, a small dataset with 240 impacts created by the quadruped robot ANYmal is included.
Sok2 Regulates Yeast Pseudohyphal Differentiation via a Transcription Factor Cascade That Regulates Cell-Cell Adhesion (2000)

In response to nitrogen limitation, Saccharomyces cerevisiae undergoes a dimorphic transition to filamentous pseudohyphal growth. In previous studies, the transcription factor Sok2 was found to negatively regulate pseudohyphal differentiation. By genome array and Northern analysis, we found that genes encoding the transcription factors Phd1, Ash1, and Swi5 were all induced in sok2/sok2 hyperfilamentous mutants. In accord with previous studies of others, Swi5 was required for ASH1 expression. Phd1 and Ash1 regulated expression of the cell surface protein Flo11, which is required for filamentous growth, and were largely required for filamentation of sok2/sok2 mutant strains. These findings reveal that a complex transcription factor cascade regulates filamentation. These findings also reveal a novel dual role for the transcription factor Swi5 in regulating filamentous growth. Finally, these studies illustrate how mother-daughter cell adhesion can be accomplished by two distinct mechanisms: one involving Flo11 and the other involving regulation of the endochitinase Cts1 and the endoglucanase Egt2 by Swi5.
A double-sided single-chip wireless pressure sensor (2003)

This paper presents the design and realization of a single-chip wireless pressure sensor implementing battery-free passive telemetry for transcutaneous pressure monitoring. The device is realized using a double-sided silicon-on-glass process integrating a high-Q inductor and a capacitive pressure transducer on opposite sides of a glass substrate. Batch-fabricated gold beam-lead inter-connects provide low-impedance connections from the front to the back of the glass die. The fabricated device measures 6 mm/spl times/6 mm/spl times/0.5 mm, and can be read out at distances greater than 3 cm over a pressure range of 400 mmHg to 1000 mmHg.
Networked Haptic Virtual Environments Supporting Ultra High Resolution Display (2009)

With HPC (high performance computing) and scientific computing, it has been possible to produce a large amount of data. To easily analyze those data and collaborate on it, visualization in terms of ultra high resolution is desired. However, in order to combine a HPC system with a high resolution display system, high system resource is required. This paper shows an example of a system combining both a haptic system requiring high speed computing and a ultra high resolution display system. Thus, in this paper, we realize a networked haptic virtual environment system over ultra high resolution tiled display. With a networked haptic virtual environment supporting ultra high resolution display, users can feel sense of touch with haptic device and see visuals in ultra high resolution manner with network tiled display when users collaborate in shared virtual environment together. In addition, in this paper, a frame rate control scheme, making the networked haptic virtual environment system over ultra high resolution display stable, is proposed.
How smart is your BEOL? productivity improvement through intelligent automation (2017)

The back end of line (BEOL) workflow in the mask shop still has crucial issues throughout all standard steps which are inspection, disposition, photomask repair and verification of repair success. All involved tools are typically run by highly trained operators or engineers who setup jobs and recipes, execute tasks, analyze data and make decisions based on the results. No matter how experienced operators are and how good the systems perform, there is one aspect that always limits the productivity and effectiveness of the operation: the human aspect. Human errors can range from seemingly rather harmless slip-ups to mistakes with serious and direct economic impact including mask rejects, customer returns and line stops in the wafer fab. Even with the introduction of quality control mechanisms that help to reduce these critical but unavoidable faults, they can never be completely eliminated. Therefore the mask shop BEOL cannot run in the most efficient manner as unnecessary time and money are spent on processes that still remain labor intensive. The best way to address this issue is to automate critical segments of the workflow that are prone to human errors. In fact, manufacturing errors can occur for each BEOL step where operators intervene. These processes comprise of image evaluation, setting up tool recipes, data handling and all other tedious but required steps. With the help of smart solutions, operators can work more efficiently and dedicate their time to less mundane tasks. Smart solutions connect tools, taking over the data handling and analysis typically performed by operators and engineers. These solutions not only eliminate the human error factor in the manufacturing process but can provide benefits in terms of shorter cycle times, reduced bottlenecks and prediction of an optimized workflow. In addition such software solutions consist of building blocks that seamlessly integrate applications and allow the customers to use tailored solutions. To accommodate for the variability and complexity in mask shops today, individual workflows can be supported according to the needs of any particular manufacturing line with respect to necessary measurement and production steps. At the same time the efficiency of assets is increased by avoiding unneeded cycle time and waste of resources due to the presence of process steps that are very crucial for a given technology. In this paper we present details of which areas of the BEOL can benefit most from intelligent automation, what solutions exist and the quantification of benefits to a mask shop with full automation by the use of a back end of line model.
A Recyclable Nanoparticle‐Supported Palladium Catalyst for the Hydroxycarbonylation of Aryl Halides in Water (2010)

Boomerang catalysis: A catalyst catch–release system is established by the noncovalent attachment of a Pd N-heterocyclic carbene complex to graphene-coated magnetic Co nanoparticles. The immobilization by pyrene tags (see scheme; blue) is reversible at elevated temperatures, releasing the homogeneous catalyst. The hydroxycarbonylation of aryl halides is performed in 16 iterative reactions with this highly active catalyst. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Resistance of DB1 Transgenic Rice Line and others against Nilaparvata lugens, Brown Planthopper (2020)

Nilaparvata lugens (Stål), brown planthopper (BPH) is as a major pest of rice crop. Developing rice resistant to BPH is an economically and environmentally friendly approach. A transgenic rice line with DB1 (Dioscorea batatas tuber lectin 1) transgene has been engineered to overcome the problem. The objective of the experiment was to obtain the level of resistance of a DB1 rice line (DB1-inserted cv. Taichung 65) and some rice genotypes against two colonies of BPH. Resistance study was performed in BPH’s preference, honeydew excretion, crop damage, and population development. The resistant test was carried out using two biotypes BPH i.e., biotype 2 (Sukamandi) and biotype 3 (North Sumatera). The result showed that DB1 transgenic rice was moderately resistant to biotype 2, while to be susceptible when invested to biotype 3, indicating that the DB1 gene increases the resistance level, from susceptible to moderately resistant. All tested genotypes were chosen by biotype 2 for laying eggs, while for biotype 3 preferred five genotypes (DB1 transgenic line, PTB-33, Babawee, IR-64 dan IR-42). Genotype significantly differed on number of BPH and was considerably lower on PTB-33 than the others. Honeydew excretion of genotypes showed equal on biotype 2 and 3, except on biotype 3 of IR 42 (susceptible to BPH) which showing high amount of feces. PTB 33 had lower BPH population as compared to others, indicating high resistance to BPH of biotype 2 and 3 from Indonesia.
Statistical static timing analysis with conditional linear MAX/MIN approximation and extended canonical timing model (2006)

An efficient and accurate statistical static timing analysis (SSTA) algorithm is reported in this paper, which features 1) a conditional linear approximation method of the MAX/MIN timing operator, 2) an extended canonical representation of correlated timing variables, and 3) a variation pruning method that facilitates intelligent tradeoff between simulation time and accuracy of simulation result. A special design focus of the proposed algorithm is on the propagation of the statistical correlation among timing variables through nonlinear circuit elements. The proposed algorithm distinguishes itself from existing block-based SSTA algorithms in that it not only deals with correlations due to dependence on global variation factors but also correlations due to signal propagation path reconvergence. Tested with the International Symposium on Circuits and Systems (ISCAS) benchmark suites, the proposed algorithm has demonstrated very satisfactory performance in terms of both accuracy and running time. Compared with Monte-Carlo-based statistical timing simulation, the output probability distribution got from the proposed algorithm is within 1.5% estimation error while a 350 times speed-up is achieved over a circuit with 5355 gates.
High-voltage pulser for ultrasound medical imaging applications (2011)

This paper presents the design and implementation of a fully integrated high-voltage (HV) front-end transducer for MEMS ultrasonic applications. Each of the front-end transducers in the array includes a HV transmitting driver and a 50MHz capacitive micro-machined ultrasound transducer (CMUT). The design adapts low voltage integrated circuit (IC) design techniques to create integrated high voltage interfaces. Effective methods to implement high voltage interfaces to integrated CMOS/DMOS circuits are presented. Using a 0.18μm CMOS/DMOS process, simulation results of this interface IC show that can generated a 30V high voltage pulse from a 1.8V input triggering signal to drive a 50MHz MEMS ultrasound transducer with the largest 44pF capacitive load.
Analytic theory for the switch from Bloch to Néel domain wall in nanowires with perpendicular anisotropy (2015)

Rectangular nanowires may have domain walls nucleated and moved through them to realize many devices. It has been shown that at a particular width and thickness of a nanowire with perpendicular anisotropy, there is a switch from the domain wall being of Bloch-type to it being of N\'eel-type. This critical shape can be found through micromagnetics simulations, but here we present an analytic calculation for the energies of both wall types involving approximations for the demagnetizing energy density. The approximations implemented include a one-dimensional model of the magnetization and a simplified initial magnetization configuration whereby the demagnetizing energy density is solved through an iterative process. The expressions developed are long, but have the advantage that by simply inputting material parameters for the magnetic material, the critical shape can be found using a calculator in a matter of seconds. We compare our results to those found using micromagnetics and those found experimentally and the agreement is good.
Withanolides potentiate apoptosis, inhibit invasion, and abolish osteoclastogenesis through suppression of nuclear factor-κB (NF-κB) activation and NF-κB–regulated gene expression (2006)

The plant Withania somnifera Dunal (Ashwagandha), also known as Indian ginseng, is widely used in the Ayurvedic system of medicine to treat tumors, inflammation, arthritis, asthma, and hypertension. Chemical investigation of the roots and leaves of this plant has yielded bioactive withanolides. Earlier studies showed that withanolides inhibit cyclooxygenase enzymes, lipid peroxidation, and proliferation of tumor cells. Because several genes that regulate cellular proliferation, carcinogenesis, metastasis, and inflammation are regulated by activation of nuclear factor-kappaB (NF-kappaB), we hypothesized that the activity of withanolides is mediated through modulation of NF-kappaB activation. For this report, we investigated the effect of the withanolide on NF-kappaB and NF-kappaB-regulated gene expression activated by various carcinogens. We found that withanolides suppressed NF-kappaB activation induced by a variety of inflammatory and carcinogenic agents, including tumor necrosis factor (TNF), interleukin-1beta, doxorubicin, and cigarette smoke condensate. Suppression was not cell type specific, as both inducible and constitutive NF-kappaB activation was blocked by withanolides. The suppression occurred through the inhibition of inhibitory subunit of IkappaB alpha kinase activation, IkappaB alpha phosphorylation, IkappaB alpha degradation, p65 phosphorylation, and subsequent p65 nuclear translocation. NF-kappaB-dependent reporter gene expression activated by TNF, TNF receptor (TNFR) 1, TNFR-associated death domain, TNFR-associated factor 2, and IkappaB alpha kinase was also suppressed. Consequently, withanolide suppressed the expression of TNF-induced NF-kappaB-regulated antiapoptotic (inhibitor of apoptosis protein 1, Bfl-1/A1, and FADD-like interleukin-1beta-converting enzyme-inhibitory protein) and metastatic (cyclooxygenase-2 and intercellular adhesion molecule-1) gene products, enhanced the apoptosis induced by TNF and chemotherapeutic agents, and suppressed cellular TNF-induced invasion and receptor activator of NF-kappaB ligand-induced osteoclastogenesis. Overall, our results indicate that withanolides inhibit activation of NF-kappaB and NF-kappaB-regulated gene expression, which may explain the ability of withanolides to enhance apoptosis and inhibit invasion and osteoclastogenesis.