gebhart/patrepeval huggingface dataset:
Broadband infrared generation with noncollinear optical parametric processes on periodically poled LiNbO_3 (2001)

Broadband signal and idler generation based on the spectral retracing behavior in noncollinear phase matching of optical parametric generation in periodically poled LiNbO(3) (PPLN) is reported. Using PPLN of 29.5-mum quasi-phase-matching period and a Q-switched Nd:YAG laser as a pump, we obtained a broad signal spectrum from 1.66 to 1.96 mum and corresponding idler wavelengths from 2.328 to 2.963 mum. The experimental results were consistent with theoretical predictions. Circular and elliptical pump beams were also compared.
Ion Transport and Switching Currents in Smectic Liquid Crystal Devices (2007)

In SSFLC and AFLC devices, the voltage over the liquid crystal is not only determined by the applied voltage, but also by the separation of ions and the spontaneous polarization. The motion of ions and the switching of the spontaneous polarization are therefore interfering phenomena. A simplified model for ion transport and switching of polarization
ArabidopsisDCP2, DCP1, and VARICOSE Form a Decapping Complex Required for Postembryonic Development (2006)

mRNA turnover in eukaryotes involves the removal of m7GDP from the 5' end. This decapping reaction is mediated by a protein complex well characterized in yeast and human but not in plants. The function of the decapping complex in the development of multicellular organisms is also poorly understood. Here, we show that Arabidopsis thaliana DCP2 can generate from capped mRNAs, m7GDP, and 5'-phosphorylated mRNAs in vitro and that this decapping activity requires an active Nudix domain. DCP2 interacts in vitro and in vivo with DCP1 and VARICOSE (VCS), an Arabidopsis homolog of human Hedls/Ge-1. Moreover, the interacting proteins stimulate DCP2 activity, suggesting that the three proteins operate as a decapping complex. Consistent with their role in mRNA decay, DCP1, DCP2, and VCS colocalize in cytoplasmic foci, which are putative Arabidopsis processing bodies. Compared with the wild type, null mutants of DCP1, DCP2, and VCS accumulate capped mRNAs with a reduced degradation rate. These mutants also share a similar lethal phenotype at the seedling cotyledon stage, with disorganized veins, swollen root hairs, and altered epidermal cell morphology. We conclude that mRNA turnover mediated by the decapping complex is required for postembryonic development in Arabidopsis.
Management of Pelvic Complications of Malignant Urothelial Tumors With Combined Intra-Arterial and IV Chemotherapy (1983)

No AccessJournal of Urology1 Aug 1983Management of Pelvic Complications of Malignant Urothelial Tumors With Combined Intra-Arterial and IV Chemotherapy C.J. Logothetis, M.L. Samuels, S. Wallace, V. Chuang, A. Trindade, C. Grant, T.P. Haynie, and D.E. Johnson C.J. LogothetisC.J. Logothetis More articles by this author , M.L. SamuelsM.L. Samuels More articles by this author , S. WallaceS. Wallace More articles by this author , V. ChuangV. Chuang More articles by this author , A. TrindadeA. Trindade More articles by this author , C. GrantC. Grant More articles by this author , T.P. HaynieT.P. Haynie More articles by this author , and D.E. JohnsonD.E. Johnson More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)51188-XAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Management of Pelvic Complications of Malignant Urothelial Tumors With Combined Intra-Arterial and IV Chemotherapy." The Journal of Urology, 130(2), p. 403 © 1983 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 130Issue 2August 1983Page: 403 Advertisement Copyright & Permissions© 1983 by The American Urological Association Education and Research, Inc.MetricsAuthor Information C.J. Logothetis More articles by this author M.L. Samuels More articles by this author S. Wallace More articles by this author V. Chuang More articles by this author A. Trindade More articles by this author C. Grant More articles by this author T.P. Haynie More articles by this author D.E. Johnson More articles by this author Expand All Advertisement PDF downloadLoading ...
Категорія «класичне» в масовому суспільному сприйнятті: історичний і сучасний погляд. (2018)

Мета роботи полягає у визначенні категорії класичного як поняття в широкому сенсі слова в сучасній суспільній свідомості. Багатогранний зміст поняття «класичного» має на увазі можливість широкого використання як в області предметного і матеріального аналізу речей, так і для аналізу нематеріальних: духовних, естетичних, культурних та інших цінностей. Методи дослідження - історико-логічний, структурно - функціональний, які дозволили проаналізувати і розкрити основні сторони досліджуваної категорії. Наукова новизна роботи полягає в розширенні уявлень про значення категорії класичного. Запропоновано якісні складові категорії класичного, відокремлено фактори, які формують смисловий зміст поняття «класичне»: 1. Гармонія; 2. Об'єктивна краса; 3. Ідеал; 4. Простота і доступність розуміння форми; 5. Зміст думки в певній формі; 5. Втілення реалістичної краси. Ряд чинників і визначень повинні бути присутніми при смисловому використанні слова «класичне»: 1. Закінчена творіння думки, предмета має видиму, яку було чути, відчутну і певну людиною (суспільством) форму як «класичне». 2. Незмінність існуючого «класичного» творіння, яке відноситься до певного часу створення. 3. Простота єдиної форми, в якій зібрано зміст всіх якісних складових визначення «класичного». 4. Історичний час існування «класичного» творіння. Висновки. Рамки використання терміна, який фактично є догматичним і прийнятим у світовій практиці, підкоряються потребам суспільства, і використовуються в сучасному просторі як частина культурної спадщини. Сутність категорії «класичне» двоїста: з одного боку, «зразковий» - це певний абсолют і ідеал, який було виміряно і затверджений історичним часом його існування, з іншого - це зразок, який дає можливість для подальшого творчого розвитку та створення нових зразків.
Magnetic dissipation force microscopy (1997)

A method of measuring magnetic dissipation on a sub-100 nm scale is presented. This technique relies on measuring changes in the damping of the oscillating tip in a magnetic force microscope (MFM). Damping contrast is strongly correlated with micromagnetic structure and in the case of NiFe, is in quantitative agreement with magnetoelastic losses in the sample. On recording tracks, large damping signals are observed. This has direct consequences on the interpretation of traditional MFM images acquired with detectors that convolute frequency and damping information.
Lung Deposition of Nebulized Surfactant in Newborn Piglets (2015)

Using this nebulizer, the lung depositions of porcine surfactant were 45% via endotracheal tube and 14% via nasal-continuous positive airway pressure (prongs). These figures might be physiologically relevant, but still have to be confirmed in efficacy studies.
Association of Low Level Viremia with Inflammation and Mortality in HIV-Infected Adults (2011)

HIV RNA ≥ 10,000 copies/ml was associated with higher IL-6 and fibrinogen, but lower levels of viremia appeared similar, and there was little association with CRP. The relationship of HIV RNA with IL-6 was strongly affected by CD4 cell depletion. After adjustment for CD4+ cell count and inflammation, viremia did not appear to be substantially associated with mortality risk over 5 years.
INTRAOPERATIVE OPTICAL SPECTROSCOPY IDENTIFIES INFILTRATING GLIOMA MARGINS WITH HIGH SENSITIVITY (2007)

We have developed a handheld, optical spectroscopic device that may be used rapidly and in near real time with high sensitivity and reproducibility as an optical tissue discrimination tool in glioma surgery.
Effects of film thickness and preferred orientation on the dielectric properties of (Bi1.5Zn0.5)(Zn0.5Nb1.5)O7films (2007)

(Bi1.5Zn0.5)(Zn0.5Nb1.5)O7 (BZN) films with different thicknesses and preferred orientations have been fabricated on Nb doped SrTiO3 substrates by pulsed laser deposition. As the thickness increases, the permittivity increases, and the dielectric loss decreases, while the tunability only has a little variation. The asymmetric behaviour of the electric field dependent permittivity reduces gradually with the increasing thickness, which should be attributed to the decrease in the effect of the interfacial layer between the dielectric film and substrate (electrode). Furthermore, compared with the (1 0 0) oriented BZN film, BZN film with (1 1 1) preferred orientation exhibits high dielectric loss.
The incorporation of [3H]glycerol and 1-[14C]acyl-sn-glycero-3-phosphocholine into different molecular species of phosphatidylcholine in human platelets (1984)

The molecular species of phosphatidylcholine which are formed by de novo synthesis and by the acylation of 1-acyl-sn-glycero-3-phosphocholine were characterized and compared in human platelets. For this purpose, intact human platelets were incubated in the presence of [3H]glycerol or 1-[14C]palmitoyl-sn-glycero-3-phosphocholine and the newly formed radioactive phosphatidylcholine was isolated by thin-layer chromatography. The labelled phosphatidylcholines were converted to their 1,2-diacylglycerol acetate derivatives and fractionated into their various chemical classes (saturates, monoenes, dienes, trienes, tetraenes, and greater than tetraenes) by argentation thin-layer chromatography. Regardless of the precursor used, the radioactivity distributions among the various classes did not correspond closely to that of the mass. The highest percentage of the radioactivity incorporated from [3H]glycerol was found in the saturates (25% of total), followed closely by the tetraenes (21%) and monoenes (18%), with lesser amounts in the dienes (15%), pentaenes plus hexaenes (14%), and trienes (7%). These results indicate that the de novo pathway is capable of substantial synthesis of tetraenoic (1-acyl 2-arachidonoyl) phosphatidylcholine in human platelets in contrast to previous observations in rat liver. In close agreement with work in rat liver, 59% of the radioactivity in the [14C]phosphatidylcholine derived from 1-[14C]palmitoyl-sn-glycero-3-phosphocholine was found in the tetraenoic species. The present results, together with the existence of phospholipase A2 and acyltransferase activity in platelets, support the potential importance of a deacylation-acylation cycle enrichment of human platelet phosphatidylcholine in arachidonoyl species.
The Nerve-Growth Factor Signaling in Gender-Related Cancers (2023)

The nerve-growth factor (NGF) was initially identified as a promoter of neuronal survival and differentiation. As such, it has captured the interest of neurobiologists for a long time. Nowadays, NGF is considered a multifaceted molecule with pleiotropic effects in quite divergent cell types, including hormone-dependent cancer cells. Many tumors exhibit derangements of nerve-growth factor and its receptors, including the tropomyosin receptor kinase A (TrkA). This receptor is frequently expressed in triple-negative breast cancers (TNBC), as well as prostate cancers (PC), although its role in the pathogenesis and aggressiveness of these diseases is still under investigation. We now report that the treatment of TNBC as well as PC-derived cells with NGF triggers the proliferation and survival of these cells. Simultaneously, NGF fosters cell motility and induces invasiveness in these cells by acting on the release of metalloproteases-9 (MMP-9). The somatic knockdown of TrkA or its pharmacologic inhibition by the specific inhibitor GW441756 impair these effects. A strong reduction in TNBC or PC-derived spheroid size is observed upon GW441756 treatment. The relevance of our studies is based on the novelty that further exploration of NGF pathway derangements in gender-related cancers will likely offer innovative targets and treatment opportunities in the clinical management of TNBC as well as PC patients.
WSN lifetime elongation via hybrid routing (2016)

Wireless sensor networks is one of the most promising elements of the Internet-of-Things. Faced with many challenges, energy dissipation and lifetime are among the main performance metrics that require improvement. In this paper, a new hybrid routing protocol is proposed to elongate the lifetime of a sensor network. The proposed hybrid protocol overcomes the LEACH-C shortcomings and exploits the advantages of direct transmission. The proposed protocol is tested, through simulation, on various network sizes and various numbers of sensors. It is shown that the proposed hybrid protocol provides lifetime improvement over both LEACH-C and direct transmission. It is shown also that such improvement depends on the network parameters, namely the size and the number of sensors. Hence, scenarios where the hybrid protocol provides significant improvement are distinguished from those where it provides modest improvements.
Unresolved Challenges with Insulin Therapy in Type 1 and Type 2 Diabetes: Potential Benefit of Replacing Amylin, a Second β -Cell Hormone (2002)

Current insulin therapy still fails to safely restore near-normoglycemia in the majority of patients. Among the barriers to achieving tight long-term glycemic control with insulin in both type 1 and type 2 diabetes are an increased risk of hypoglycemia, undesired weight gain, and a failure to normalize postprandial hyperglycemia and excessive unpredictable diurnal glucose fluctuations. Amylin is a second beta-cell hormone that is cosecreted with insulin in response to meals, and is deficient in patients with type 1 and insulin-requiring type 2 diabetes. Preclinical studies indicate that amylin acts as a neuroendocrine hormone that complements the effects of insulin in postprandial glucose regulation by suppressing postprandial glucagon secretion and slowing the rate of nutrient delivery from the stomach to the small intestine. Human amylin is not optimal for replacement therapy because of its propensity to aggregate; thus, pramlintide, a soluble, nonaggregating synthetic peptide analog of human amylin, was developed that has potency at least equal to that of human amylin. In clinical studies, subcutaneous injections of pramlintide prior to meals, in addition to insulin therapy, significantly reduced postprandial glucose excursions and lowered HbA(1c) levels in patients with type 1 and type 2 diabetes. The improvement in long-term glycemic control was associated with a significant reduction in body weight and occurred without increases in total daily insulin use or in overall severe hypoglycemia event rates. Because of this unique spectrum of clinical effects, amylin replacement with pramlintide as an adjunctive therapy to insulin is a promising approach that may fulfill some of the unmet clinical needs of insulin-using patients with type 1 and type 2 diabetes.
Untargeted Metabolomics on Skin Mucus Extract of Channa argus against Staphylococcus aureus: Antimicrobial Activity and Mechanism (2021)

Microbial contamination is one of the most common food safety issues that lead to food spoilage and foodborne illness, which readily affects the health of the masses as well as gives rise to huge economic losses. In this study, <i>Channa argus</i> was used as a source of antimicrobial agent that was then analyzed by untargeted metabolomics for its antibacterial mechanism against <i>Staphylococcus aureus</i>. The results indicated that the skin mucus extract of <i>C. argus</i> had great inhibitory action on the growth of <i>S. aureus</i>, and the morphology of <i>S. aureus</i> cells treated with the skin mucus extract exhibited severe morphological damage under scanning electron microscopy. In addition, metabolomics analysis revealed that skin mucus extract stress inhibited the primary metabolic pathways of <i>S. aureus</i> by inducing the tricarboxylic acid cycle and amino acid biosynthesis, which further affected the normal physiological functions of biofilms. In conclusion, the antimicrobial effect of the skin mucus extract is achieved by disrupting cell membrane functions to induce an intracellular metabolic imbalance. Hence, these results conduce to amass novel insights into the antimicrobial mechanism of the skin mucus extract of <i>C. argus</i> against <i>S. aureus</i>.
Positive and negative interactions of GDNF, NTN and ART in developing sensory neuron subpopulations, and their collaboration with neurotrophins (2000)

Glial cell line-derived neurotrophic factor (GDNF), neurturin (NTN) and neublastin/artemin (ART) are distant members of the transforming growth factor beta family, and have been shown to elicit neurotrophic effects upon several classes of peripheral and central neurons. Limited information from in vitro and expression studies has also substantiated a role for GDNF family ligands in mammalian somatosensory neuron development. Here, we show that although dorsal root ganglion (DRG) sensory neurons express GDNF family receptors embryonically, they do not survive in response to their ligands. The regulation of survival emerges postnatally for all GDNF family ligands. GDNF and NTN support distinct subpopulations that can be separated with respect to their expression of GDNF family receptors, whereas ART supports neurons in populations that are also responsive to GDNF or NTN. Sensory neurons that coexpress GDNF family receptors are medium sized, whereas small-caliber nociceptive cells preferentially express a single receptor. In contrast to brain-derived neurotrophic factor (BDNF)-dependent neurons, embryonic nerve growth factor (NGF)-dependent nociceptive neurons switch dependency to GDNF, NTN and ART postnatally. Neurons that survive in the presence of neurotrophin 3 (NT3) or neurotrophin 4 (NT4), including proprioceptive afferents, Merkel end organs and D-hair afferents, are also supported by GDNF family ligands neonatally, although at postnatal stages they lose their dependency on GDNF and NTN. At late postnatal stages, ART prevents survival elicited by GDNF and NTN. These data provide new insights on the roles of GDNF family ligands in sensory neuron development.
Residual Life Prediction of Rotating Machines Using Acoustic Noise Signals (2012)

While automated condition monitoring of rotating machines often use vibration signals for defect detection, diagnosis, and residual life predictions, in this paper, the acoustic noise signal (<; 25 kHz), acquired via non-contact microphone sensors, is used to predict the remaining useful life (RUL). Modulation spectral (MS) analysis of acoustic signals has the potential to provide additional long-term information over more conventional short-term signal spectral components. However, the high dimensionality of MS features has been cited as a limitation to their applicability in this area in the literature. Therefore, in this study, a novel approach is proposed which employs an information theoretic approach to feature subset selection of modulation spectra features. This approach does not require information regarding the spectral location of defect frequencies to be known or pre-estimated and leverages information regarding the chronological order of data samples for dimensionality reduction. The results of this study show significant improvements for this proposed approach over the other commonly used spectral-based approaches for the task of predicting RUL by up to 19% relative over the standard envelope analysis approach used in the literature. A further 16% improvement was achieved by applying a more rigorous approach to labeling of acoustic samples acquired over the lifetime of the machines over a fixed length class labeling approach. A detailed misclassification analysis is provided to interpret the relative cost of system errors for the task of residual life predictions of rotating machines used in industrial applications.
Identifying ECUs Using Inimitable Characteristics of Signals in Controller Area Networks (2018)

As the functions of vehicles are more computerized for the safety and convenience of drivers, attack surfaces of vehicle are accordingly increasing. Many attack results have shown that an attacker could intentionally control vehicles. Most of them exploit the vulnerability that controller area network (CAN) protocol, a de-facto standard for the in-vehicle networks, does not support message origin authentication. Although a number of methods to resolve this security vulnerability have been suggested, they have their each limitation to be applied into the current system. They have required either the modification of the CAN standard or dramatical communication load increase, which is infeasible in practice. In this paper, we propose a novel identification method, which works in the physical layer of the in-vehicle CAN network. Our method identifies electronic control units (ECUs) using inimitable characteristics of electrical CAN signals enabling detection of a malicious ECU. Unlike previous attempts to address the security problem in the in-vehicle CAN network, our method works by simply adding a monitoring unit to the existing network, making it deployable in current systems and compliant with required CAN standards. Our experimental results show that our method is able to correctly identify ECUs. In case of misclassfication rate for ECU idnetification, our method yields 0.36% in average which is approximate four times lower than the method proposed by P.-S. Murvay et al. This paper is also the first to identify potential attack models that systems should be able to detect.
NUMERICAL SIMULATION OF CAPILLARY TUBES. APPLICATION TO DOMESTIC REFRIGERATION WITH ISOBUTANE (2010)

This work presents the implementation and validation of a numerical model that simulates the thermal and fluiddynamic phenomena inside capillary tubes.The algorithm is based on a two-phase flow model where the governing equations (continuity, momentum, energy and entropy) are integrated over the discretized fluid domain and solved by means of a step-by-step scheme.The numerical procedure considers four different transitional regions (subcooled liquid region, metastable liquid region, metastable two-phase flow region and equilibrium two-phase flow region), allows the prediction of both critical and non-critical flow conditions, and evaluates the heat exchanged between the capillary tube and the compressor suction line.The model predictions have been compared against experimental data sets including adiabatic and non-adiabatic conditions.In addition, a parametric study on capillary tubes used in household refrigerators and working with isobutane has been carried out (different geometric conditions were considered).
Successful Application of the Derived Crystal Packing (DCP) Model in Resolving the Crystal Structure of a Metastable Polymorph of (±) Modafinil (2004)

Polymorphic forms I and III of (±) modafinil have been studied. In contrast to the structure of form I which could be solved by using conventional single crystal X-ray diffraction, the crystal structure of form III could not be elucidated due to the shape and the size of the single crystals resulting from the high supersaturation under which this phase is obtained. To bypass the problem, the derived crystal packing (DCP) model has been successfully applied by recombining the slice (002)A extracted from form I. The calculated XRPD pattern of form III fits well with the experimental data. The extensive similarities between the two crystal structures are carefully detailed.
Epitaxial growth of beta -SiC on Si by RTCVD with C/sub 3/H/sub 8/ and SiH/sub 4/ (1992)

The authors established that beta -SiC thin films can be grown epitaxially on