gebhart/patrepeval huggingface dataset:
Hexavalent chromium intoxication induces intrinsic and extrinsic apoptosis in human renal cells (2019)

Hexavalent chromium [Cr(VI)], is a well‑known toxic form of the heavy metal chromium in the natural environment. Clinical evidence has indicated that exposure to Cr(VI) can cause severe renal damage. The production of reactive oxygen species (ROS) due to intracellular reduction of Cr(VI) is the main mechanism underlying the induction of cellular dysfunction and apoptosis. The present study aimed to investigate in detail the apoptotic pathways induced by Cr(VI)‑exposure in a human immortalized proximal tubular epithelial cell line HK‑2, in order to understand the mechanism involved therein. Exposure to 10 µM potassium dichromate (K2Cr2O7), a toxic compound of Cr(VI), significantly decreased cell viability after 24 and 48 h of incubation and induced intracellular ROS generation. The expression levels of markers that activate the apoptotic pathway including cleaved caspase‑3 and poly (ADP‑ribose) polymerase were significantly upregulated in K2Cr2O7‑exposed HK‑2 cells. In addition, the induction of intrinsic and extrinsic apoptotic markers was detected in K2Cr2O7‑exposed HK‑2 cells. In summary, the present study described for the first time the novel apoptotic mechanism of Cr(VI)‑toxicity in human renal cells which may be beneficial in designing optimal clinical treatment for renal damage caused by acute Cr(VI) toxicity.
Role of Carbohydrate in Stabilizing the Triple-Helix in a Model for a Deep-Sea Hydrothermal Vent Worm Collagen (2003)

The glycopeptide Ac-(Gly-Pro-Thr(beta-Gal))(10)-NH(2) forms a collagen-like triple-helix. A (1)H NMR structural analysis is reported for the peptides Ac-(Gly-Pro-Thr)(n)-NH(2) and Ac-(Gly-Pro-Thr(beta-Gal))(n)-NH(2), where n = 1, 5, and 10. NMR assignments for the individual peptides are made using one- and two-dimensional TOCSY, ROESY, and NOESY experiments. The NMR and corroborating CD data show that Ac-(Gly-Pro-Thr)(n)-NH(2), n = 1, 5, or 10, as well as Ac-(Gly-Pro-Thr(beta-Gal))(n)-NH(2), n = 1 or 5 peptides are unable to form collagen-like triple-helical structures. Furthermore, the equilibrium ratio of cis to trans isomers of the Pro residues is unaffected by the presence of carbohydrate. For Ac-(Gly-Pro-Thr(beta-Gal))(10)-NH(2), the kinetics of amide (1)H exchange with solvent deuterium indicate a slow rate of exchange for both the Gly and the Thr amide. The data are thus consistent with a model in which the carbohydrate stabilizes the triple helix through an occlusion of water molecules and by hydrogen bonding but not through an influence on the cis to trans isomer ratio.
Bandwidth Investigation on Half-Height Pin in Ridge Gap Waveguide (2017)

Gap waveguide is a promising transmission structure, especially for millimeter-wave (mmW) and terahertz applications. It does not require conductive connection between the upper and the lower plates, which makes this technology gain advantages over conventional rectangular waveguides and substrate integrated waveguides in an mmW and terahertz regime. Different fabrication methods for gap waveguides should be employed for different frequency bands applied, such as molding, milling, die forming, electrical discharge machining, microelectromechanical systems, and 3-D printing. Therefore, different pin forms used in gap waveguides are required to match the applied fabrication methods. In this paper, a new pin form, the half-height-pin form, in gap waveguides is proposed for reducing the fabrication cost, and its stopband characteristics are investigated and compared with the previous full-height pins in gap waveguides at the V-band. A device of a double-ridged gap waveguide with two 90° bends for verifying the stopband characteristic analysis of the new pin form has been designed and manufactured. The measured data confirm our analysis and simulations.
Konzeption und Evaluation von 3D-Pattern zur Komplexitätsreduzierung in der Prozessführung (2005)

In der Prozess- und Prozessdatenvisualisierung werden weitestgehend 2D-Darstellungsformen angewendet. 3D-Darstellungen kommen trotz ausreichender Hard- und Softwareressourcen kaum zum Einsatz, da über den Nutzen dreidimensionaler Visualisierungen wenig bekannt ist und der Aufwand zur Erstellung von 3D-Prozessvisualisierungen als zu hoch eingeschätzt wird. Der vorliegende Beitrag stellt eine Auswahl dreidimensionaler Darstellungsmöglichkeiten vor und beschreibt Anwendungsmöglichkeiten in der Prozess- und Prozessdatenvisualisierung. Zudem wird eine Vorgehensweise vorgestellt, die den Anwender bei der Entwicklung von dreidimensionalen Mensch-Maschine-Schnittstellen unterstützt.
Preparation and characterization of a monoclonal antibody against boar acrosin. (1986)

BALB/c mice were immunized with the crude fraction of boar acrosin. Immune spleen cells were fused with myeloma cells SP2/0-Ag14. One of the 6 hybridomas produced was cloned and characterized by ELISA and SDS-PAGE. Possible uses of the monoclonal antibody against acrosin for immunological detection of the amount of acrosin liberated after manipulations with spermatozoa and for selection of undamaged spermatozoa for insemination are discussed.
Uranium(VI) Adsorption on Goethite and Soil in Carbonate Solutions (1996)

Abstract Elevated concentrations of U are found in agricultural drainage waters from the San Joaquin Valley, CA, which are often disposed of in evaporation basins that are frequented by waterfowl. To determine the factors that affect aqueous U concentrations in the basins, sorption experiments with U(VI) were performed at various CO 2 partial pressures, dissolved Ca, Mg, and P concentrations, and carbonate alkalinities. Synthetic waters, comparable in inorganic constituents to irrigation and drainage waters, were prepared, spiked with 0.1 (soil) and 2 mg U(VI) L −1 (synthetic goethite), and analyzed for U, P (when applicable), and major ions. Total chemical analyses were input into the computer program FITEQL to determine U(VI) speciation and generate U(VI) adsorption constants with the diffuse layer model (also referred to as the two‐layer model ). Maximum adsorption occurred in solutions with low carbonate alkalinities (≤3 mmol L −1 ), ionic strengths (≤0.03 M ), Ca concentrations (≤4 mmol L −1 ), and P concentrations (&lt;0.005 mmol L −1 for soil). Lesser and negligible adsorption was attributed to the predicted formation of highly soluble, negatively charged U(VI) carbonates [UO 2 (CO 3 ) 2− 2 and UO 2 (CO 3 ) 4− 3 ] that did not strongly adsorb to soil surfaces. Calcium and, to some degree, Mg competition with positively charged U(VI) species for surface sites was observed at low carbonate alkalinities (&lt;3 mmol L −1 for goethite; &lt;14 mmol L −1 for soil). At high carbonate alkalinities, carbonates competed with anionic U(VI) species for adsorption sites. Study results suggest that elevated U concentrations in the drainage waters are due to the speciation of dissolved U(VI) into negatively charged carbonate complexes.
Cardioprotective Effects of Qishenyiqi Mediated by Angiotensin II Type 1 Receptor Blockade and Enhancing Angiotensin-Converting Enzyme 2 (2012)

The aim of this paper was to investigate whether the effects of QSYQ on CHD are associated with the renin-angiotensin-aldosterone system (RAAS). The formula groups were lavaged with QSYQ, using fosinopril sodium as a control. The level of RAAS components in the myocardial tissue was measured, respectively. The results showed that both QSYQ and fosinopril sodium can improve the ejection fraction in CHD and that QSYQ decreases the left ventricular end-systolic diameter and left ventricular end-diastolic diameter, while fosinopril sodium has no effects on these parameters. Fosinopril sodium, as an ACE inhibitor, downregulated ACE expression and eventually reduced the tissue AngII concentration but had no effect on ACE2. Moreover, it had no effect on renin or AT2, while QSYQ significantly decreased the level of renin and expression of AngII in myocardial tissue. The results also revealed that QSYQ can act on both AT1 and AT2, thus, blocking the effect of AngII and increasing the level of ACE2. It also downregulated the levels of TGF-β and MMP-9, but it had no effect on ACE. This study showed that the ameliorative effects of QSYQ on CHD in rats had multiple targets associated with the inhibition of RAAS, thus, producing cardioprotective therapy effects.
Data from Evaluation of Emergent Mutations in Circulating Cell-Free DNA and Clinical Outcomes in Patients with Metastatic Colorectal Cancer Treated with Panitumumab in the ASPECCT Study (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;Mutations in &lt;i&gt;EGFR&lt;/i&gt; pathway genes are poor prognostic indicators in patients with metastatic colorectal cancer. Plasma analysis of cell-free DNA is a minimally invasive and highly sensitive method to detect somatic mutations in tumors.&lt;/p&gt;Experimental Design:&lt;p&gt;Plasma samples collected from panitumumab-treated patients in the ASPECCT study at baseline and safety follow-up (SFU) were analyzed by a next-generation sequencing–based approach for extended &lt;i&gt;RAS&lt;/i&gt; mutant allele frequency as a continuous variable and their association with clinical outcomes and the mutational prevalence of 63 cancer-related genes. The correlation between patient outcome and baseline mutational status of &lt;i&gt;EGFR&lt;/i&gt; pathway genes was also examined.&lt;/p&gt;Results:&lt;p&gt;Overall, 261 patients in the panitumumab arm had evaluable plasma samples. Patients with a higher &lt;i&gt;RAS&lt;/i&gt; mutant allele frequency at baseline had worse clinical outcomes than those with a lower frequency (&lt;i&gt;P&lt;/i&gt; &lt; 0.001, Cox PH model); however, &lt;i&gt;RAS&lt;/i&gt; mutations did not necessarily preclude patients from deriving benefits. The objective response rate (complete or partial response) was 10.8% for patients with baseline &lt;i&gt;RAS&lt;/i&gt; mutations and 21.7% for those with &lt;i&gt;BRAF&lt;/i&gt; mutations. The 63-gene panel analysis revealed an increase in tumor mutational burden from baseline to SFU (&lt;i&gt;P&lt;/i&gt; &lt; 0.001, Wilcoxon signed rank test). Baseline mutations in &lt;i&gt;EGFR&lt;/i&gt; pathway genes, when analyzed both categorically and continuously, were associated with shorter survival.&lt;/p&gt;Conclusions:&lt;p&gt;When mutations in &lt;i&gt;EGFR&lt;/i&gt; pathway genes were analyzed continuously, higher mutant allele frequency correlated with poorer outcomes. However, extended &lt;i&gt;RAS&lt;/i&gt; mutation, by itself, did not preclude clinical responses to panitumumab in a monotherapy setting.&lt;/p&gt;&lt;/div&gt;
Optical Fiber Design And Fabrication: Discussion On Recent Developments (2008)

Level of emitted power and beam quality of singlemode fiber lasers have been drastically increased at the expense of loss due to bend sensitivity, simplicity of manufacturing and packaging. Furthermore, the extension of the spectral coverage was primarily explored by exploiting non-linear effects, neglecting numerous possible transitions of rare earths. Through different research areas, we demonstrate the possibilities offered by new fiber designs and alternative methods of manufacturing. Photonic Band Gap fibers reconcile diffraction limited beam and large mode area with low bending loss. 80 % slope efficiency is demonstrated together with a robust propagation allowing the fiber to be tightly bent until wounding radii as small as 6 cm. Highly ytterbium doped multimode core surrounded by high refractive index rods fiber exhibits a transverse singlemode behavior under continuous wave laser regime. A robust lp 01 mode is observed and filtering effect is clearly observed. A non CVD process based on silica sand vitrification allows the synthesis of large and highly doped core with high index homogeneity, opening the way to design of efficient large mode area fiber lasers. 74% slope efficiency is measured, demonstrating the good quality of the core material. Finally, the use of rare earth (Er 3+ ) doped zirconia nanocrystals in silica matrix offers a large panel of ignored energy transitions for visible or off-usual band of emission.
A query processing strategy for the decomposed storage model (1987)

Handling parallelism in database systems involves the specification of a storage model, a placement strategy, and a query processing strategy. An important goal is to determine the appropriate combination of these three strategies in order to obtain the best performance advantages. In this paper we present a novel and promising query processing strategy for a decomposed storage model. We discuss some of the qualitative advantages of the scheme. We also compare the performance of the proposed “pivot” strategy with conventional query processing for the n-ary storage model. The comparison is performed using the Wisconsin Benchmarks.
Automatic application-specific instruction-set extensions under microarchitectural constraints (2003)

Many commercial processors now offer the possibility of extending their instruction set for a specific application---that is, to introduce customised functional units. There is a need to develop algorithms that decide automatically, from high-level application code, which operations are to be carried out in the customised extensions. A few algorithms exist but are severely limited in the type of operation clusters they can choose and hence reduce significantly the effectiveness of specialisation. In this paper we introduce a more general algorithm which selects maximal-speedup convex subgraphs of the application dataflow graph under fundamental microarchitectural constraints, and which improves significantly on the state of the art.
Continuous usage of a hair dye product containing 2‐methoxymethyl‐para‐phenylenediamine by hair‐dye‐allergic individuals (2016)

Hair dye products with the less sensitizing ME-PPD were tolerated by 29 of 43 (67%) PPD/PTD-allergic individuals throughout continued hair dyeing with an average of nine treatments per year. Five individuals reacted upon pretesting, while only mild-to-moderate/marked skin reactions occurred upon hair dyeing in nine individuals who were not identified by the pretest. To our knowledge this is the first study among PPD/PTD-allergic individuals indicating that a negative 45-min pretest with a hair dye product helps to avoid severe allergic reactions.
FUTURES: a mechanism for concurrency among objects (1989)

A future provides the basic primitive through which a user in an object-oriented distributed system can achieve concurrency. It is based on the notion of being able to translate what appears to be a remote procedure call into a request for computation to be scheduled by the system. The mechanism required to make this translation is discussed. Refinements to the future mechanism allow futures to be passed as arguments to other procedure calls. This provides the user with the added flexibility of implementing synchronization schemes suited to specific needs. Further, it simplifies the process of migrating an object which has outstanding futures at the time of migration.
355 nm Multiphoton Dissociation and Ionization of 2, 5-Dihydroxyacetophenone (2009)

Multiphoton dissociation and ionization of 2,5-dihydroxyacetophenone (DHAP), an important matrix compound in UV matrix-assisted laser desorption/ionization (MALDI), is studied in a molecular beam at 355 nm using multimass ion imaging mass spectrometer and time-of-flight mass spectrometry. For laser fluence larger than 130 mJ/cm(2), nearly all of the irradiated molecules absorb at least one photon. The absorption cross section was found to be sigma = 1.3(+/-0.2) x 10(-17)cm(2). Molecules excited by two photons quickly dissociate into fragments. The major channels are (1) C(6)H(3)(OH)(2)COCH(3) --> C(6)H(3)(OH)(2)CO + CH(3) and (2) C(6)H(3)(OH)(2)COCH(3) --> C(6)H(3)(OH)(2) + COCH(3). Molecules absorbing three or more photons become parent ions or crack into smaller ionic fragments. The concentration ratio of ions (parent ions and ionic fragments) to neutral fragments is about 10(-6):1. Changing the molecular beam carrier gas from He at 250 Torr to Ar at 300 Torr results in molecular beam clustering (dimers and trimers). Multiphoton ionization of clusters by a 355 nm laser beam produces only dimer cations, (C(6)H(3)(OH)(2)COCH(3))(2)(+). Protonated clusters or negatively charged ions, observed from a solid sample of DHAP using 355 nm multiphoton ionization, were not found in the molecular beam. The experimental results indicate that the photoionization occurs in the gas phase after DHAP vaporizes from the solid phase may not play an important role in the MALDI process.
Partitioning of Seven Different Classes of Antibiotics into LPS Monolayers Supports Three Different Permeation Mechanisms through the Outer Bacterial Membrane (2021)

The outer membrane (OM) of Gram-negative (G-) bacteria presents a barrier for many classes of antibacterial agents. Lipopolysaccharide (LPS), present in the outer leaflet of the OM, is stabilized by divalent cations and is considered to be the major impediment for antibacterial agent permeation. However, the actual affinities of major antibiotic classes toward LPS have not yet been determined. In the present work, we use Langmuir monolayers formed from <i>E. coli</i> Re and Rd types of LPS to record pressure-area isotherms in the presence of antimicrobial agents. Our observations suggest three general types of interactions. First, some antimicrobials demonstrated no measurable interactions with LPS. This lack of interaction in the case of cefsulodin, a third-generation cephalosporin antibiotic, correlates with its low efficacy against G- bacteria. Ampicillin and ciprofloxacin also show no interactions with LPS, but in contrast to cefsulodin, both exhibit good efficacy against G- bacteria, indicating permeation through common porins. Second, we observe substantial intercalation of the more hydrophobic antibiotics, novobiocin, rifampicin, azithromycin, and telithromycin, into relaxed LPS monolayers. These largely repartition back to the subphase with monolayer compression. We find that the hydrophobic area, charge, and dipole all show correlations with both the mole fraction of antibiotic retained in the monolayer at the monolayer-bilayer equivalence pressure and the efficacies of these antibiotics against G- bacteria. Third, amine-rich gentamicin and the cationic antimicrobial peptides polymyxin B and colistin show no hydrophobic insertion but are instead strongly driven into the polar LPS layer by electrostatic interactions in a pressure-independent manner. Their intercalation stably increases the area per molecule (by up to 20%), which indicates massive formation of defects in the LPS layer. These defects support a self-promoted permeation mechanism of these antibiotics through the OM, which explains the high efficacy and specificity of these antimicrobials against G- bacteria.
HTLV-1 clonality during chronic infection and BLV clonality during primary infection (2011)

HTLV-1 persists by driving clonal proliferation of infected T-lymphocytes. A high proviral load predisposes to the inflammatory and malignant diseases associated with HTLV-1. Yet the reasons for the remarkable variation within and between individuals in the abundance of HTLV-1-infected clones remain unknown. We demonstrate that negative selection dominates during chronic infection, favouring establishment of proviruses integrated in transcriptionally silenced DNA: this selection is significantly stronger in asymptomatic carriers. We postulated that this selection occurred mainly during the primary infection. We are testing this hypothesis in an animal model by studying the BLV clonality during the primary infection in cows. By measuring the proviral load, the anti-BLV immune response and the BLV clonality we aim to quantify the impact of the immune response on the rate of infectious spread and on the selection of proviruses inserted in a particular genomic environment. Co-infection with Strongyloides stercoralis or Staphylococcus appears to be another risk factor for the development of HTLV-1 associated diseases. We observed that HTLV-1 clonality is altered by co-infection with these pathogens with an increase of both the number and the abundance of the infected T-cell clones. The genomic characteristics of the proviral integration sites in the most abundant clones differ significantly between co-infected individuals and those with HTLV-1 alone, implying the existence of different selection forces in co-infected patients. The rate of appearance of new clones in patients co-infected with Strongyloides stercoralis is higher than in patients with HTLV-1 alone. By comparing skin lesions and blood samples from patients with Infective Dermatitis associated with HTLV-1 (IDH), we observed a significant proportion of distinct infected clones between the two compartments. The skin lesions seem to be a site for HTLV-1 infectious spread.
A Comparitive Study of Four Different Shaped Frequency Reconfigurable Log Periodic Microstrip Antenna Arrays (2013)

This paper describes the design and simulation of four frequency reconfigurable three element log-periodic microstrip antenna arrays. A comparative study is presented using rectangular, square, triangular and circular patch elements.The three patches fed by inset feed line technique are connected with a single transmission line by a log-periodic array formation to form a wideband frequency from 2.9 to 3.4 GHz. By applying three PIN diodes modules at the transmission line, two different sub-band frequencies are configured by switching ON and OFF the switches.The frequency responses of these arrays are analysed using the Zealands IE3D commercial software that implements the method of moments. After the simulations were completed, different shaped Log PeriodicAntennas(LPA) were compared in terms of return loss, realized gain and directivity. Key words: log-periodic antenna, microstrip, reconfigurable, wideband.
FOURTH SUNDAY OF EASTER (2015)

WELCOME TO WORSHIP! It is our privilege to have you here with us today! We are especially delighted to welcome all our guests who are with us. May the Holy Spirit bless your worship and fill your heart with peace, joy, and faith in your Savior Jesus Christ. Please introduce yourself, sign our guest book in the entryway, and worship with us again soon!  Restroom and nursery facilities (with a video link) are located across from the west (drive-up) entrance.  If you have any questions about our congregation's ministries or facilities, please do not hesitate to ask one of our Elders. If you are looking for a church home or have questions about what we believe and teach, please speak to Pastor.
Re-Identification Supervised Texture Generation (2019)

The estimation of 3D human body pose and shape from a single image has been extensively studied in recent years. However, the texture generation problem has not been fully discussed. In this paper, we propose an end-to-end learning strategy to generate textures of human bodies under the supervision of person re-identification. We render the synthetic images with textures extracted from the inputs and maximize the similarity between the rendered and input images by using the re-identification network as the perceptual metrics. Experiment results on pedestrian images show that our model can generate the texture from a single image and demonstrate that our textures are of higher quality than those generated by other available methods. Furthermore, we extend the application scope to other categories and explore the possible utilization of our generated textures.