gebhart/patrepeval huggingface dataset:
Pyrolysis of Esters. VII. Influence of Acid Portion1,2 (1956)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPyrolysis of Esters. VII. Influence of Acid Portion1,2WILLIAM J. BAILEY and JOHN J. HEWITTCite this: J. Org. Chem. 1956, 21, 5, 543–546Publication Date (Print):May 1, 1956Publication History Published online1 May 2002Published inissue 1 May 1956https://pubs.acs.org/doi/10.1021/jo01111a016https://doi.org/10.1021/jo01111a016research-articleACS PublicationsRequest reuse permissionsArticle Views177Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Anti-progesterone effects on maternal recognition and behaviour imprinted during first pregnancy in mice (1995)

Anti-progesterone treatment using specific anti-progesterone antibodies or a progesterone receptor (PR) antagonist during first pregnancy impairs postpartum maternal behaviour in mice. This effect is demonstrable only if the treatment is given during pregnancy but not immediately after parturition. The purpose of the present studies was to investigate if maternal behaviour is also impaired by anti-progesterone treatment in subsequent pregnancies. Studies with a monoclonal antibody to progesterone (DB3; 4.5 nmol/mouse) showed that injection of females on day 17 of second pregnancy did not cause maternal rejection but the latency of pup retrieval was prolonged especially during the first 3 days of lactation. This phenomenon was not observed in animals that had previous experience of full length lactation. Experiments were carried out with mifepristone (RU486; 10 micrograms/mouse) injected at day 17 of first, second or third pregnancies. Pup rejection (22.5% vs 12.3%) and prolongation of the retrieval latency (62.3 +/- 13.3 vs 19.7 +/- 6.5 s; P < 0.02) were observed following the first pregnancy. No abnormal behavioural effects were found in mothers treated in second or third pregnancy who had prior full length lactation experience. Control females subjected to only one pup retrieval test after first delivery rejected their pups if treated in their second pregnancy (27.3% vs 4.4%; P < 0.001) and displayed a marginal prolongation of the retrieval latency period (20.9 +/- 7.0 vs 7.4 +/- 2.6 s). Anti-progesterone treatment had no negative influence when administered during third pregnancy.(ABSTRACT TRUNCATED AT 250 WORDS)
The role of fimbriae and flagella in the colonization, invasion and persistence of Escherichia coli O78[ratio ]K80 in the day-old-chick model (2000)

To understand the role of flagella and fimbriae of Escherichia coli O78:K80 in avian colibacillosis, day-old chicks were dosed orally with defined afimbriate and or aflagellate mutants and colonization, invasion and persistence compared with that of the wild-type. In an invasion model, chicks were dosed with 1 x 10(5) c.f.u. of a single strain and mutants defective for type 1 fimbriae, curli fimbriae or flagella colonized livers by 24 h although the numbers of bacteria present were significantly less than the wild-type. Mutants colonized between 50 and 75% of spleens whereas the wild-type colonized 100% of spleens. Additionally, the numbers of mutant bacteria in colonized spleens were significantly less than the wild-type. Surprisingly, mutants defective for the elaboration of more than one appendage were no more attenuated than single mutants. In a persistence model, chicks were dosed with 1 x 10(2) c.f.u. of a single strain and mutants defective for type 1 or curli or flagella or any combination thereof persisted as assessed by cloacal swabbing for 5 weeks of the experiment less well than the wild-type. In an additional persistence model, chicks were dosed with 5 x 10(2) c.f.u. of each of wild-type and one mutant together. All mutants were significantly less persistent than the wild-type (P < 0.001) and one mutant which lacked type 1, curli and flagella, was eliminated within 2 weeks. Analysis of the trends of elimination indicated that flagella contributed to persistence more than curli, which contributed more than type 1 fimbriae. Here was evidence for a major role in colonization, invasion and persistence played by type 1, curli and flagella.
Evaluation of matrix scaffolds for tissue engineering of articular cartilage grafts (1997)

Injury to articular cartilage predisposes that joint to further degeneration and eventually osteoarthritis. Recent studies have demonstrated the feasibility of using chondrocytes together with different biomaterial carriers as grafts for the repair of cartilage defects. The following study was undertaken to determine the effect of a variety of these materials on chondrocyte growth and extracellular matrix synthesis. We cultured chondrocytes on several commonly used materials and compared their rates of synthesis of proteoglycan and collagen. Additionally, we evaluated them in a closed culture recirculating system on these materials and compared them with standard culture techniques. This was done to see whether such a bioreactor-type system can be used to enhance the quality of in vitro reconstructed tissues. Our results demonstrated marked variability with respect to how chondrocytes responded to culture on the various materials. Bioabsorbable polymers such as polyglycolic acid (PGA)--enhanced proteoglycan synthesis, whereas collagen matrices stimulated synthesis of collagen. The use of the closed culture system, in general, improved the rates of synthesis of collagen and proteoglycan on the different material scaffolds. Exceptions were collagen synthesis on collagen matrices: use of the closed culture system did not enhance the rate of synthesis. Rates of proteoglycan synthesis on PGA scaffold initially was higher in the closed culture system but did not sustain a difference over the entire course of the 3-week culture period. This study demonstrates the importance of carrier material for the purpose of cartilage tissue reconstruction in vitro.
Patients’ Organizations and Their Opinions: How Much Have They Been Taken into Consideration When Regulating Stem Cell Research? (2010)

As advances in stem cell research have accelerated, a growing chorus of concern has emerged worldwide, that traditional values have been put aside in the quest for scientific progress. Almost uniquely within biomedical research, stem cell research offers the potential to improve the health of patients living with a wide range of medical conditions. At the same time, such research also poses deep ethical and moral dilemmas that may impede the progression of the development of new medicines or therapies, that aim to improve the lives and suffering of patients living with a variety of complex disorders. Medical and religious ethics have been drawn into a complex social and political debate around future directions of stem cell research and how this should be funded within diverse national and European systems. The development of the patient advocacy movement, within diverse international health care systems has now developed into a profoundly influential force that, for the first time, is now engaged in the debate around the allocation of European research funding and the future directions of translational stem cell research. Patients with a variety of conditions have expressed views that their suffering is real now and is often profound. This suffering needs to be considered in the context of a complex moral and ethical debate, particularly where this is driven politically active groups, whose views or beliefs are not shared by patients. How do we, as a diverse society, pursue research in order to alleviate long term suffering and endeavour to progress research sensitively, all within a pluralistic society? In this context, religious ethics also have to be considered within a multi faith framework and progress needs to be made, while trying to reconcile the diversity of viewpoints. Future research directions must be pursued with stringent and enforceable rules, regulations, and public oversight, anchored both in law and reverence. With the further extension of influence of the patient advocacy into the realm of health care research and perhaps, the allocation of health care funding, we must make a plea for patient responsibility and awareness of the needs of all constituencies within an increasingly complex international health care environment.
Approaches to cryptographic key management (1986)

Article Free Access Share on Approaches to cryptographic key management Author: Paul G. Comba IBM Corporation IBM CorporationView Profile Authors Info & Claims PCS '86: Proceedings of the Northeast ACM symposium on Personal computer securitySeptember 1986 Pages 38–45https://doi.org/10.1145/318772.318781Online:01 September 1986Publication History 0citation412DownloadsMetricsTotal Citations0Total Downloads412Last 12 Months0Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF
Partially Purified Extracts of Sea AnemoneAnemonia viridisAffect the Growth and Viability of Selected Tumour Cell Lines (2016)

In the last few years, marine species have been investigated for the presence of natural products with anticancer activity. Using reversed phase chromatography, low molecular weight proteins were fractionated from the sea anemone <i>Anemonia viridis</i>. Four different fractions were evaluated for their cytotoxic activity by means of erythrocyte haemolysis test, MTS, and LDH assays. Finally, the antiproliferative activities of three of these fractions were studied on PC3, PLC/PRF/5, and A375 human cancer cell lines. Our analysis revealed that the four fractions showed different protein contents and diverse patterns of activity towards human PBMC and cancer cell lines. Interestingly, fractions III and IV exerted cytotoxic effects on human cells. Conversely, fractions I and II displayed very low toxic effects associated with antiproliferative activities on cancer cell lines.
OSEM reconstruction, associated with temporal fourier and depth-dependant resolution recovery filtering, enhances results from sestamibi and 201Tl 16-interval gated SPECT. (2005)

OSEM associated with temporal Fourier filtering and depth-dependant resolution recovery filtering enhances the LV function assessment provided by sestamibi and (201)Tl 16-interval gated SPECT and dramatically reduces image noise, a property that enhances and facilitates image interpretation.
Change of organized solution (microemulsion) structure with small change in surfactant composition as revealed by NMR self-diffusion studies (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChange of organized solution (microemulsion) structure with small change in surfactant composition as revealed by NMR self-diffusion studiesBjoern Lindman, Kozo Shinoda, Mikael Jonstroemer, and Akira ShinoharaCite this: J. Phys. Chem. 1988, 92, 16, 4702–4706Publication Date (Print):August 1, 1988Publication History Published online1 May 2002Published inissue 1 August 1988https://pubs.acs.org/doi/10.1021/j100327a029https://doi.org/10.1021/j100327a029research-articleACS PublicationsRequest reuse permissionsArticle Views113Altmetric-Citations31LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Cigarette smoke increases TLR4 and TLR9 expression and induces cytokine production from CD8+T cells in chronic obstructive pulmonary disease (2011)

Our results demonstrate increased expression of TLR4 and TLR9 on lung CD8(+) T cells in COPD. CD8(+) T cells exposed to CSC increased TLR4 and TLR9 levels and increased cytokine production. These results provide a new perspective on the role of CD8(+) T cells in COPD.
Applications and developments part 2: general discussion (2021)

Vera Butova opened discussion of the paper by Natalia Shustova: How did you measure the conductivity of MOFs? In the form of powder or films? Does activation or temperature affect their conductivity? Did you somehow directly observe the switching process in the spiropyran (SP) molecule?
Multiple imprinted sense and antisense transcripts, differential methylation and tandem repeats in a putative imprinting control region upstream of mouse  Igf2 (1997)

The mouse insulin-like growth factor 2 (Igf2) locus is a complex genomic region that produces multiple transcripts from alternative promoters. Expression at this locus is regulated by parental imprinting. However, despite the existence of putative imprinting control elements in the Igf2 upstream region, imprinted transcriptional repression is abolished by null mutations at the linked H19 locus. To clarify the extent to which the Igf2 upstream region contains autonomous imprinting control elements we have performed functional and comparative analyses of the region in the mouse and human. Here we report the existence of multiple, overlapping imprinted (maternally repressed) sense and antisense transcripts that are associated with a tandem repeat in the mouse Igf2 upstream region. Regions flanking the repeat exhibit tissue-specific parental allelic methylation patterns, suggesting the existence of tissue-specific control elements in the upstream region. Studies in H19 null mice indicate that both parental allelic methylation and monoallelic expression of the upstream transcripts depends on an intact H19 gene acting in cis. The homologous region in human IGF2 is structurally conserved, with the significant exception that it does not contain a tandem repeat. Our results support the proposal that tandem repeats act to target methylation to imprinted genetic loci.
Making of The Superpunch (2005)

The Superpunch is the final punch Neo that delivers to Agent Smith in the final installment of The Matrix trilogy during the film's last face-off. It was the first shot that the directors Larry and Andy Wachowski and their conceptual designer storyboarded for the sequels. (The shot's storyboards were also the first storyboards to leak out on the Internet back in Spring 2000). The Superpunch was meant to show, in familiar Bullet Time, the event of Neo's super-powerful last punch that occurs over a fraction of a second and lands on Smith's face deforming it in a surreal, anime-like fashion. As a Bullet Time shot, it was to feature an impossible virtual camera yet it had to look real. The nature of the push-in camera move and the requirement of punching someone with an inhumanly strong force meant that the original multiple still camera rig approach could not be deployed. The shot went through many different stages of visualizations, breakdowns, and considerations. The Superpunch became even more challenging when we learned that it had to happen under heavy rain. We explored creating the shot based on live action elements and augmenting it with CG elements. Tests revealed that this approach would compromise the required fluid camera. The camera was meant to glide through space showing us an exciting event from previously unseen perspectives. Around the Spring of 2003 when we had gained confidence that our 3 year-long R&D effort in realistic human face rendering technology could pull off a full-frame, slow-motion close up of a familiar actor such as Hugo Weaving, we decided to create the shot entirely in the CG world.
Repeatability of and Relationship between Potential COPD Biomarkers in Bronchoalveolar Lavage, Bronchial Biopsies, Serum, and Induced Sputum (2012)

Chronic Obstructive Pulmonary Disease (COPD) is a chronic inflammatory disease, primarily affecting the airways. Stable biomarkers characterizing the inflammatory phenotype of the disease, relevant for disease activity and suited to predict disease progression are needed to monitor the efficacy and safety of drug interventions. We therefore analyzed a large panel of markers in bronchoalveolar lavage, bronchial biopsies, serum and induced sputum of 23 healthy smokers and 24 smoking COPD patients (GOLD II) matched for age and gender. Sample collection was performed twice within a period of 6 weeks. Assays for over 100 different markers were validated for the respective matrices prior to analysis. In our study, we found 51 markers with a sufficient repeatability (intraclass correlation coefficient >0.6), most of these in serum. Differences between groups were observed for markers from all compartments, which extends (von-Willebrand-factor) and confirms (e.g. C-reactive-protein, interleukin-6) previous findings. No correlations between lung and serum markers were observed, including A1AT. Airway inflammation defined by sputum neutrophils showed only a moderate repeatability. This could be improved, when a combination of neutrophils and four sputum fluid phase markers was used to define the inflammatory phenotype.In summary, our study provides comprehensive information on the repeatability and interrelationship of pulmonary and systemic COPD-related markers. These results are relevant for ongoing large clinical trials and future COPD research. While serum markers can discriminate between smokers with and without COPD, they do not seem to sufficiently reflect the disease-associated inflammatory processes within the airways.
THE OPTIMUM LEACHING CONDITIONS OF ARTViN MURGUL CHALCOPYRITE ORE IN HYPOCHLORITE SOLUTION (2005)

The optin1un1 leaching conditions or prin1ary chalcopyrite ore tl·on1 Artvin-Murgul region in Turkey have been exan1ined in hypochlorite solution. &amp;#039;The effects of various paran1eters as initial pH, hypochlorite concentration, stirring speed, solid/liquid ratio and ternperature to the copper dissolution fron1 chalcopyrite were investigated. lt was found thatchc:1lcopyritc reacted \\\\&amp;#039;ith chlorine generated fron1 hypochlorite in acidic pH values. pi I cfTcctivcly decreased during the di. solution. It was detern1incd that the optin1un1 leaching conditions \\vere initial pll of 5-6~ hypochlorite concentration of0.2 N for 4 g/L solid/liquid ratio. 600 rpn1 stirring speed and it was seen that sulphate forn1ation was over 50%.
Development of Multi-Die Stacking with Cu-Cu interconnects using Gang Bonding Approach (2020)

Cu is prefer interconnects as compared to solder interconnects as it offered no risk of solder merging, finer pitch, no intermetallic compound formation and better electrical characteristic. However, the implementation of CuCu interconnects is not a trivial matter. It needs to overcome many challenges such as copper oxide formation, long bonding duration and stringent requirement on co-planity of Cu bump height. In this paper, we used Gang Bonding as the bonding approach to form Cu-Cu interconnects. The multi-dies were stacked on top of each other across the whole wafer without forming any interconnect. Cu-Cu interconnects were only formed between the die stacking through the application of pressure, temperature and time in the gang bonding process. Good Cu-Cu interconnects through the gang bonding approach was demonstrated successfully.
Cryo-EM reveals the architecture of placental malaria VAR2CSA and provides molecular insight into chondroitin sulfate binding (2021)

Placental malaria can have severe consequences for both mother and child and effective vaccines are lacking. Parasite-infected red blood cells sequester in the placenta through interaction between parasite-expressed protein VAR2CSA and the glycosaminoglycan chondroitin sulfate A (CS) abundantly present in the intervillous space. Here, we report cryo-EM structures of the VAR2CSA ectodomain at up to 3.1 Å resolution revealing an overall V-shaped architecture and a complex domain organization. Notably, the surface displays a single significantly electropositive patch, compatible with binding of negatively charged CS. Using molecular docking and molecular dynamics simulations as well as comparative hydroxyl radical protein foot-printing of VAR2CSA in complex with placental CS, we identify the CS-binding groove, intersecting with the positively charged patch of the central VAR2CSA structure. We identify distinctive conserved structural features upholding the macro-molecular domain complex and CS binding capacity of VAR2CSA as well as divergent elements possibly allowing immune escape at or near the CS binding site. These observations will support rational design of second-generation placental malaria vaccines.
Low‐temperature sintering of single‐phase, high‐entropy carbide ceramics (2019)

Abstract Dense (Hf, Zr, Ti, Ta, Nb)C high‐entropy ceramics were produced by hot pressing (HP) of carbide powders synthesized by carbothermal reduction (CTR). The relative density increased from 95% to 99.3% as the HP temperature increased from 1750°C to 1900°C. Nominally phase pure ceramics with the rock salt structure had grain sizes ranging from 0.6 µm to 1.2 µm. The mixed carbide powders were synthesized by high‐energy ball milling (HEBM) followed by CTR at 1600°C, which resulted in an average particle size of ~100 nm and an oxygen content of 0.8 wt%. Low sintering temperature, high relative densities, and fine grain sizes were achieved through the use of synthesized powders. These are the first reported results for low‐temperature densification and fine microstructure of high‐entropy carbide ceramics.
Development of fiber optic sensor systems (1994)

A number of the recent developments in the field of fiber optic interferometric sensing will be discussed. The major areas in which these developments occurred will be briefly reviewed.
Supplementary Table 1 from l-2-Hydroxyglutarate: An Epigenetic Modifier and Putative Oncometabolite in Renal Cancer (2023)

&lt;p&gt;Supplementary Table 1. Clinical Data on Tumor Samples.&lt;/p&gt;
The Effect on U.S. Banking of Payment System Changes (2004)

The focus of this paper is on the changes underway that influence the health of the banking industry in the United States. At the outset, it should be noted that the United States is somewhat of an outlier among developed nations when it comes to the nature of its payment systems.