gebhart/patrepeval huggingface dataset:
A family of Salmonella virulence factors functions as a distinct class of autoregulated E3 ubiquitin ligases (2009)

Processes as diverse as receptor binding and signaling, cytoskeletal dynamics, and programmed cell death are manipulated by mimics of host proteins encoded by pathogenic bacteria. We show here that the Salmonella virulence factor SspH2 belongs to a growing class of bacterial effector proteins that harness and subvert the eukaryotic ubiquitination pathway. This virulence protein possesses ubiquitination activity that depends on a conserved cysteine residue. A crystal structure of SspH2 reveals a canonical leucine-rich repeat (LRR) domain that interacts with a unique E3 ligase [which we have termed NEL for Novel E3 Ligase] C-terminal fold unrelated to previously observed HECT or RING-finger E3 ligases. Moreover, the LRR domain sequesters the catalytic cysteine residue contained in the NEL domain, and we suggest a mechanism for activation of the ligase requiring a substantial conformational change to release the catalytic domain for function. We also show that the N-terminal domain targets SspH2 to the apical plasma membrane of polarized epithelial cells and propose a model whereby binding of the LRR to proteins at the target site releases the ligase domain for site-specific function.
Expression of the major capsid protein VP6 of group C rotavirus and synthesis of chimeric single-shelled particles by using recombinant baculoviruses (1992)

VP6 of group C (Cowden strain) rotavirus was expressed in the baculovirus system. The recombinant protein, expressed to a high level in insect cells, was purified by ion-exchange chromatography. The purified protein was proven to be trimeric. The effect of pH on the trimer's stability was investigated. Coexpression of VP6 from group A (bovine strain RF) and VP6 from group C in the baculovirus system did not result in the formation of chimeric trimers. Coexpression of VP2 from group A rotavirus (bovine strain RF) and VP6 from group C in the baculovirus system led to the formation of chimeric, empty, single-shelled particles. These results demonstrate conservation in the domains necessary for binding to VP2 in different serogroups of VP6. The locations of the domains involved in trimerization and in the interaction with VP2 are discussed.
Papillary microcarcinoma in comparison with larger papillary thyroid carcinoma in BRAFV600E mutation, clinicopathological features, and immunohistochemical findings (2009)

These results suggest that PMC is not an occult cancer and it can act like larger PTC. Therefore, PMC should not be underestimated in practice.
ChemInform Abstract: Deprotection of Trimethylsilyl and of Tetrahydropyranyl Ethers and of Ethylene Acetals with Benzyltriphenylphosphonium Chlorochromate. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The Rod Photoreceptors in Retinopathy of Prematurity (2001)

The rod photoreceptors must be involved in ROP. The more severe the acute phase ROP, the more severe is the compromise of the processes involved in the activation of phototransduction in the rods.
Time for new standards? (1992)

Abstract A review of The Quantum Physics of Atomic Frequency Standards. Volumes 1 and 2. By J. Vanier and C. Audoin. (Adam Hilger, 1989.) [Pp. Vol. 1. viii + 601, Vol. 2. viii + 965.] £250.00. ISBN 0 85274 434 2 (set). Scope: Monograph. Level: Postgraduate.
Genome-Wide Association Study (GWAS) of dental caries in diverse populations (2021)

The results of this study warrant further investigation and may lead to a better understanding of cariogenesis in diverse populations, and help to improve dental caries prediction, prevention, and/or treatment in future.
Air leakage around endotracheal tube cuffs (2004)

Background and objective: To compare the recently introduced Microcuff® endotracheal tube with conventional tubes in respect of the cuff pressures required to prevent air leakage. Methods: The following tubes (ID 7.0 mm) were compared: Microcuff® HVLP ICU, Mallinckrodt HiLo®, Portex Profile Soft Seal®, Rüsch Super Safety Clear® and Sheridan CF®. Fifty patients undergoing endotracheal intubation with a cuffed tube of internal diameter 7.0 mm were studied. Tracheas were intubated using one of the endotracheal tubes in random order. Cuff pressure to prevent air leakage at standardized ventilator setting (peak inspiratory pressure 20 cmH2O/PEEP 5 cmH2O/respiratory rate 15 breaths min−1) was assessed by auscultation of audible sounds at the mouth. Patients characteristics and cuff pressures from each brand were compared to the Microcuff® group using the Mann-Whitney U-test (P < 0.05 was chosen as the level of statistical significance). Results: Patients' median age (range) was 14.2 (12.0-17.1) yr, body weight 57.5 (40.0-81.9) kg and length 164.9 (146.5-190.0) cm. No significant differences in patients' characteristics were found between groups. Mean cuff pressure (all tubes) required for air sealing was 19.1 (8-42) cmH2O. The Microcuff® tube required significantly lower sealing pressures (9.5 (8-12) cmH2O) compared to the other brands of endotracheal tube (P < 0.05, Mann-Whitney U-test). Conclusion: The Microcuff® endotracheal tube with its ultra-thin polyurethane cuff membrane required the lowest sealing pressure to prevent air leakage. These features are potentially of interest for long-term intubated patients and for cuffed endotracheal tubes in children, allowing tracheal sealing at lower cuff pressures implying less damage to the trachea.
Response—The Time of Young Scientists (2010)

Article MetricsDownloadsCitationsNo data available.01234AugSepOctNovDecJan210Total6 Months12 MonthsTotal number of downloads for the most recent 6 whole calendar months.
Word-reading ability as a “hold test” in cognitively normal young adults with history of concussion and repetitive head impact exposure: A CARE Consortium Study (2019)

<b>Objective:</b> Neuropsychological evaluations include hold tests like word-reading ability as estimates of premorbid intellect thought to be resilient to the effects of neurologic insult. We tested the alternative hypothesis that exposure to concussion or repetitive subclinical head impacts throughout early life may stunt acquisition of word-reading skills.<b>Method:</b> Data were obtained from student-athletes within the CARE Consortium that completed the Wechsler Test of Adult Reading (WTAR). Measures of head trauma burden included self-reported concussion history and cumulative years of exposure to collision sports. We evaluated the effects of head trauma, sociodemographic (race, SES), and academic (SAT/ACT scores, learning disorder) variables on WTAR standard score using linear regression. Analyses were repeated in a football-only subsample estimating age of first exposure to football as a predictor.<b>Results:</b> We analyzed data from 6,598 participants (72.2% white, 39.6% female, mean ± SD age = 18.8 ± 1.2 years). Head trauma variables collectively explained 0.1% of the variance in WTAR standard scores, with years of collision sport exposure weakly predicting lower WTAR standard scores (<i>β</i> = .026-.035, very small effect). In contrast, sociodemographic and academic variables collectively explained 20.9-22.5% of WTAR standard score variance, with strongest effects noted for SAT/ACT scores (β = .313-.337, medium effect), LD diagnosis (β = -.115 to -.131, small effect), and SES (<i>β</i> = .101-.108, small effect). Age of first exposure to football did not affect WTAR scores in a football-only sample.<b>Conclusion:</b> Wechsler Test of Adult Reading performance appears unrelated to history of self-reported concussion(s) and/or repetitive subclinical head trauma exposure in current collegiate athletes. Sociodemographic and academic variables should be incorporated in test score interpretations for diverse populations like athletes.
Assessment of the pilot implementation of a game-based gear design laboratory (2011)

Taking advantage of game technology for offering truly immersive and interactive learning experiences to undergraduate engineering and science students has now become a real possibility. An immersive interactive virtual laboratory environment has been created for the laboratory component of a junior-level undergraduate mechanical engineering course on mechanisms and machine dynamics. For instance, a laboratory system implemented using a multi-player computer game engine provides the students with the flexibility to perform various experiments related to the concepts of the fundamental law of gearing and to the planetary motion of gears. Assessment tools such as pre- and post-experiment tests are an integral part of this game-based laboratory environment and form the basis for providing different levels of support to the students at every step of the laboratory exercise. Furthermore, the game environment can be equipped with functionality for monitoring the students' progress and learning outcomes, thus enabling skill-based assessment. This paper will report on the learning assessment conducted as part of a pilot implementation of this gear design laboratory. The evaluation metrics for the virtual laboratory environment as well as the collected data on learning effectiveness will be presented and the general student feedback will be discussed.
Chemical, spectral, and structural features of Mo(RC.tplbond.CR)2(S2CNC4H4)2 complexes containing the electronically unique pyrrole-N-carbodithioate ligand (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTChemical, spectral, and structural features of Mo(RC.tplbond.CR)2(S2CNC4H4)2 complexes containing the electronically unique pyrrole-N-carbodithioate ligandRichard S. Herrick, Sharon J. Nieter-Burgmayer, and Joseph L. TempletonCite this: Inorg. Chem. 1983, 22, 22, 3275–3281Publication Date (Print):October 1, 1983Publication History Published online1 May 2002Published inissue 1 October 1983https://pubs.acs.org/doi/10.1021/ic00164a021https://doi.org/10.1021/ic00164a021research-articleACS PublicationsRequest reuse permissionsArticle Views97Altmetric-Citations18LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Retribution for Rats: Cooperation, Punishment, and Atonement (2003)

(Excerpt) To mobsters, he is a "rat"; to drug dealers, a "snitch." To school children, he is a "tattletale"; to corporate executives, a "whistleblower." To cops, he is an "informant"; to prosecutors, a "cooperator." By whatever name he is known, the person who betrays his associates to the authorities is almost universally reviled. In movies, on television, in literature, the cooperator embodies all that society holds in contempt: he is disloyal, deceitful, greedy, selfish, and weak. The cooperator, though, has long been a mainstay of our criminal justice system. For centuries, criminal defendants have received leniency in return for testimony incriminating accomplices and associates. Cooperation has flourished because the participants in the process (primarily prosecutors and cooperators) reap tremendous benefits. Prosecutors want what only cooperators can offer: inside information about criminal organizations. And cooperators want what only prosecutors can offer: leniency, or at least a recommendation for leniency.
Comparative in vitro activity of semisynthetic penicillins against Proteeae (1983)

The in vitro susceptibilities of 181 isolates of precisely identified Proteeae species to five semisynthetic penicillins were determined with low and high inocula. Significant differences in susceptibility patterns among various Proteeae species to the penicillins examined were demonstrated. Providencia stuartii was clearly distinguished from Providencia alcalifaciens by its greater resistance to the antibiotics tested.
The Adequacy of Life Insurance: Evidence from the Health and Retirement Survey (1999)

This study examines the adequacy of life insurance among married American couples approaching retirement. It improves upon previous work in two ways. First, it is based on recent, high quality data (the 1992 Health and Retirement Survey with matched Social Security earnings histories). Second, it employs new financial planning software to evaluate the life insurance needs of each household. This software embodies an elaborate life-cycle planning model that accounts for a broad array of demographic, economic, and financial characteristics.
Applying Error-Correcting Output Coding to Enhance Convolutional Neural Network for Target Detection and Pattern Recognition (2010)

This paper views target detection and pattern recognition as a kind of communications problem and applies error-correcting coding to the outputs of a convolutional neural network to improve the accuracy and reliability of detection and recognition of targets. The outputs of the convolutional neural network are designed according to codewords with maximum Hamming distances. The effects of the codewords on the performance of the convolutional neural network in target detection and recognition are then investigated. Images of hand-written digits and printed English letters and symbols are used in the experiments. Results show that error-correcting output coding provides the neural network with more reliable decision rules and enables it to perform more accurate and reliable detection and recognition of targets. Moreover, our error-correcting output coding can reduce the number of neurons required, which is highly desirable in efficient implementations.
A retrograde p-well for higher density CMOS (1981)

A new technique for CMOS p-well (or n-well) formation is described, making use of a deep implant followed by a brief anneal. This results in a retrograde profile, permitting a much shallower well, a large reduction in p-n channel device spacing (5-6 µm versus 10-15 µm), and an opportunity to reduce the risk of latch-up. This technique is more conducive to scaling-with the promise of significantly better performance-than conventional well formation methods. The retrograde p-well has been successfully applied to a linearly shrunk bulk CMOS 4K static RAM, demonstrating its feasibility.
Brain MRI in neurodegeneration with brain iron accumulation with and without PANK2 mutations. (2006)

MR imaging signal intensity abnormalities in the globus pallidus can distinguish patients with mutations in PANK2 from those lacking a mutation, even in the early stages of disease.
Supplementary Figure 5 from NF-κB, and not MYCN, Regulates MHC Class I and Endoplasmic Reticulum Aminopeptidases in Human Neuroblastoma Cells (2023)

Supplementary Figure 5 from NF-κB, and not MYCN, Regulates MHC Class I and Endoplasmic Reticulum Aminopeptidases in Human Neuroblastoma Cells
Animal model of Mycoplasma fermentans respiratory infection (2013)

Mycoplasma fermentans induced a respiratory tract infection and persisted in different organs for several weeks in hamsters. This finding may help to explain the ability of Mycoplasma fermentans to induce pneumonia and chronic infectious diseases in humans.
Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells (2009)

The polycomb repressive complex (PRC) 2 contains 3 core proteins, EZH2, SUZ12, and EED, in which the SET (suppressor of variegation-enhancer of zeste-trithorax) domain of EZH2 mediates the histone methyltransferase activity. This induces trimethylation of lysine 27 on histone H3, regulates the expression of HOX genes, and promotes proliferation and aggressiveness of neoplastic cells. In this study, we demonstrate that treatment with the S-adenosylhomocysteine hydrolase inhibitor 3-deazaneplanocin A (DZNep) depletes EZH2 levels, and inhibits trimethylation of lysine 27 on histone H3 in the cultured human acute myeloid leukemia (AML) HL-60 and OCI-AML3 cells and in primary AML cells. DZNep treatment induced p16, p21, p27, and FBXO32 while depleting cyclin E and HOXA9 levels. Similar findings were observed after treatment with small interfering RNA to EZH2. In addition, DZNep treatment induced apoptosis in cultured and primary AML cells. Furthermore, compared with treatment with each agent alone, cotreatment with DZNep and the pan-histone deacetylase inhibitor panobinostat caused more depletion of EZH2, induced more apoptosis of AML, but not normal CD34(+) bone marrow progenitor cells, and significantly improved survival of nonobese diabetic/severe combined immunodeficiency mice with HL-60 leukemia. These findings indicate that the combination of DZNep and panobinostat is effective and relatively selective epigenetic therapy against AML cells.
2A2-L05 In-pipe Mobile Robot by Peristalsis Motion Using Shape Memory Alloy(Mobile Robot with Special Mechanism) (2011)

There are many various movements in the natural world. Peristalsis motion like an earthworm is useful to progress in any confined spaces. In this study, our purpose is development of earthworm robot which is useful to progress in the narrow pipe. An actuator of the earthworm robot was BioMetal Fiber (BMF series) which is one of the shape memory alloys. BMF, elongated at room temperature, becomes stiff and sharply contract when a current is fed through it. The mechanism of using BMF is lighter and smaller than any other mechanisms, such as DC motor, servo motor and air pressure.
Development of Amplified Redox Sensor Suitable for Onsite Measurement (2018)

The redox sensor is a type of electrochemical sensors that can detect chemical substances from redox response derived from the characteristics of the substance. Redox sensor is attractive due to their fast response, sensitivity, simplicity and miniaturization. Therefore, redox sensor is expected to be applied to onsite monitoring. However, the redox output current is reduced if the sensing area is small and/or the concentration of the sample is low. We proposed an amplified redox sensor (ARS), which combines the sensing area that serves as a working electrode with a bipolar transistor. For onsite detection, portable small size device that can measure even small concentrations is required. In this paper, we report the performance limit of our proposed ARS from input referred current noise that we calculated from measurement conditions of cyclic voltammetry and square wave voltammetry using potassium ferricyanide. In addition, we compared to MOSFET based transimpedance amplifier of a single element. As a result, bipolar transistor based the ARS can expect low detection limit about 2 orders of magnitude lower. Hence, we believe that the proposed amplified redox sensor devices can be used in high sensitivity on-site monitoring in electrochemical measurements.
An improved speculum. (1980)

Spreading the lids for intraocular surgery is a mechanical act. Theoretically there are five mechanical directions of movement, four of which are clinically relevant to lid separation. This speculum provides adjustment of all four dimensions.
Robust Parameter Subset Selection and Optimal Experimental Design for Effective Parameterization of PEM Fuel Cell Models (2020)

We address the problem of identifying the parameters of a polymer electrolyte membrane (PEM) fuel cell model when no prior parameter estimates are available. To this end, we build upon a recently developed parameter identification framework and use an extended local sensitivity analysis to obtain a more global picture of parameter sensitivities. The extended analysis consists of local analyses carried out at multiple sampled points in the parameter space. The results from this extended analysis are then used to optimally select a subset of parameters for identification. Particularly, the selected subset optimizes the expected value of the well-known D-criterion over the parameter space. Being derived from the extended analysis, the selected subset is robust to initial assumptions about the nominal parameter values. Similar procedures are then used for robust optimal experimental design (OED) for the purpose of parameter identification. The robust OED approach is benchmarked against another experimental design method based on Latin Hypercube Sampling (LHS). The effectiveness of the proposed methods is investigated by identifying model parameters using synthetic data. The results demonstrate the utility of the robust parameter subset selection and OED procedures in enabling accurate parameter identification.
Discrete and continuous description of a three-dimensional scene for quality control of radiotherapy treatment planning systems (2006)

Quality Control (QC) procedures are mandatory to achieve accuracy in radiotherapy treatments. For that purpose, classical methods generally use physical phantoms that are acquired by the system in place of the patient. In this paper, the use of digital test objects (DTO) replace the actual acquisition<sup>1</sup>. A DTO is a 3D scene description composed of simple and complex shapes from which discrete descriptions can be obtained. For QC needs, both the DICOM format (for Treatment Planning System (TPS) inputs) as well as continuous descriptions are required. The aim of this work is to define an equivalence model between a continuous description of the three dimensional (3D) scene used to define the DTO, and the DTO characteristics. The purpose is to have an XML- DTO description in order to compute discrete calculations from a continuous description. The defined structure allows also to obtain the three dimensional matrix of the DTO and then the series of slices stored in the DICOM format. Thus, it is shown how possibly design DTO for quality control in CT simulation and dosimetry.
Silica coating of the pore walls of a microporous polycaprolactone membrane to be used in bone tissue engineering (2013)

Polycaprolactone/silica microporous hybrid membranes were produced in two steps: A microporous polycaprolactone membrane with an interconnected porosity of 80% was obtained via a freeze extraction procedure, then silica was formed by a sol-gel reaction inside the micropores using tetraethyl orthosilicate, TEOS, as silica precursor. It is shown that silica forms a thin coating layer homogeneously distributed over the pore walls when sol-gel reaction is catalyzed by hydrochloric acid, while it forms submicron spherical particles when using basic catalyzer. Some physical properties and the viability and osteoblastic differentiation of bone marrow rat mesenchymal stem cells cultured on pure and hybrid membranes were studied.