gebhart/patrepeval huggingface dataset:
Multiple attenuation using a high-resolution time-domain Radon transform (2006)

A high-resolution time-domain Radon transform is used to identify and separate multiple energy from seismic reflection energy. The transform used is an optimized semblance-weighted Radon transform. In this method, the highest energy trajectories are identified first in the Radon domain, then the energy is subtracted immediately from the source gather before it is used by other trajectories. This process improves the spatial resolution of the energy in the Radon domain. The high-resolution time-domain Radon transform was applied to real and synthetic data and produced encouraging results.
Self-Supporting Tire Performance Criteria and Testing (1998)

&lt;div class="htmlview paragraph"&gt;In recent years, consumer demand for self-supporting tires has increased and significant development has occurred in the tire industry. Consequently, several self-supporting tires have been launched into the market. Given the special nature of the design and the unique performance characteristics, new considerations have to be introduced into the realm of tire and vehicle evaluation. The most notable of these are those related to deflated mobility. Fundamental performance characteristics are presented; general guidelines for testing and performance criteria are proposed. This information can serve as a preliminary basis for the expansion of application, and evolution of self-supporting tire designs.&lt;/div&gt;
Circuit techniques for efficient linear GaAs MMICs (1991)

Discusses the development of novel circuits for monolithic microwave integrated circuit (MMIC) technology using GaAs MESFETs, which promise the potential of high efficiency and linearity. These circuits are considered particularly important for the development of the new generation of MMIC communication circuits now emerging. The synthesis is based initially on a very simple square-law characterisation of the GaAs depletion-mode MESFET. Nonideal MESFET characteristics are included in simulations. The design of a 0.5 GHz-5 GHz GaAs MMIC isolator is used to illustrate the ideas presented. The synthesis presented is a special case of the more general method for transconductance/multiplier functions. >
A phase I trial of GRN163L (GRN), a first-in-class telomerase inhibitor, in advanced solid tumors (2008)

3581 Background: Telomerase is over-expressed in most malignancies and is the predominant mechanism by which cancer cells maintain adequate telomere length and immortalization. GRN is a 13-mer oligonucleotide direct inhibitor of the telomerase active site, and has demonstrated broad anticancer effects in preclinical models. Methods: This is a phase I dose escalation study of GRN given weekly as a 2 hr infusion to patients (pts) with refractory, advanced solid tumors. Endpoints included safety, tolerability, pharmacokinetics and efficacy. Results: As of 1/3/08, 20 pts with advanced solid tumors (including 6 colorectal, 3 lung, 2 mesothelioma, 2 pancreas, 7 other) have been treated in escalating dose cohorts at 0.4–4.8 mg/kg of GRN/wk. The pts ranged from 50–74 years of age (median 64 years) and had received 1- 10 prior chemotherapies. Most possibly/probably related adverse events have been reversible, Grade 1–2, and include aPTT prolongation, nausea, vomiting, fatigue, diarrhea, anemia, elevated GGT and peripheral neuropathy. At 3.2 mg/kg, a patient who was tolerating therapy well died of unknown cause after the 4th dose, which was considered a dose-limiting toxicity (DLT). Also, at this dose level, one pt had grade 1 thrombocytopenia during cycle 1 and a 2nd patient had cumulative thrombocytopenia (eventually grade 4 after ten doses). At 4.8 mg/kg, one pt developed grade 4 thrombocytopenia subsequent to the first 3 doses (a DLT). There has been no consistent effect upon other hematological parameters. The plasma half-life of GRN163L was approximately 4–5 hrs, without evidence of nonlinear pharmacokinetics. Conclusion: Accrual to the study continues at 4.8 mg/kg/wk. GRN causes thrombocytopenia (possibly mechanism-related) at doses >3.2 mg/kg/wk, but has not demonstrated any other major toxicities. The maximally tolerated dose appears to be >3.2 mg/kg/wk when given by 2 hr infusions. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration Geron Geron
Interventions for Preschool Children at High Risk for ADHD: A Comparative Effectiveness Review (2013)

With more studies consistently documenting effectiveness, PBT interventions have greater evidence of effectiveness than methylphenidate for treatment of preschoolers at risk for ADHD.
Clinical Activity of Flavopiridol in Relapsed and Refractory Chronic Lymphocytic Leukemia (CLL) with High-Risk Cytogenetic Abnormalities: Updated Data on 89 Patients (Pts). (2007)

Abstract Background: New therapies for relapsed CLL pts with poor-risk cytogenetic features, such as del(11q22), del(17p13) or a complex karyotype, are needed. Alemtuzumab (Campath-1H) is effective in this pt population but has infectious toxicity and is ineffective as a single agent in bulky nodal disease. Flavopiridol induces p53-independent apoptosis in CLL cells in vitro. We previously demonstrated the activity of flavopiridol in genetically high-risk CLL in a phase I study using a novel, pharmacokinetically (PK) derived dosing schedule, and we are currently pursuing a larger phase II trial of this drug. We present updated results of flavopiridol’s activity in high-risk pts in both studies. Study Design and Treatment: Pts (n=89) with symptomatic, relapsed CLL who failed (or could not receive) fludarabine received flavopiridol by 30-min IVB followed by 4-hr CIVI weekly for 4 doses, every 6 weeks for up to 6 cycles. Pts received 30 mg/m2 IVB + 30 mg/m2 CIVI (n=20), 40 mg/m2 IVB + 40 mg/m2 CIVI (n=3), 30 mg/m2 IVB + 30 mg/m2 CIVI for the first 4 doses and 30 mg/m2 IVB + 50 mg/m2 CIVI for all subsequent doses (n=14) or 30 mg/m2 IVB + 30 mg/m2 CIVI for the first dose and 30 mg/m2 IVB + 50 mg/m2 CIVI for all subsequent doses (n=44). Eight pts who experienced severe tumor lysis syndrome did not undergo dose escalation as planned. A complex karyotype was defined as ≥ 3 unrelated abnormalities, and FISH for TP53 [del(17p13)] and ATM [del(11q22)] determined loss of those genes (regions). Response Assessment: Median age was 61 years (range, 38–84), with 21 pts ≥ 70 years of age. Median number of prior therapies was 5 (range, 1–14); 87 pts had failed fludarabine therapy. Pts had bulky Rai stage I/II (n=18), III (19) or IV (n=52) disease. Pts received a median of 3 cycles (range, 0.25–6), 11 pts completed all 6 cycles, and 2 continue to receive therapy. All 89 pts were evaluated for response, including 6 pts who received only one dose due to grade 4–5 tumor lysis or other complications. Forty-one pts responded (46%) by NCI Working Group response criteria; 39 pts achieved a partial response (PR, 44%), and 2 pts with trisomy 12 achieved a complete response (CR, 2%). Fourteen of 29 pts with del(17p13) responded (48%), 22 of 37 pts with del(11q22) responded (59%), and 20 of 47 pts with a complex karyotype responded (43%). Thirty-three of 70 pts with bulky adenopathy &gt;5 cm responded (47%). Progression free survival data will be updated at ASH. Conclusions: Flavopiridol demonstrates significant clinical activity as a single agent in heavily pretreated, relapsed CLL pts with bulky adenopathy and poor-risk cytogenetic features such as del(17p13), del(11q22) and complex karytoypes. Further studies of this drug in CLL and other hematologic malignancies are ongoing. All Patients Loss TP53 Loss ATM Complex Karyotype Bulky nodes &gt; 5 cm Patients 89 29 37 47 70 Partial Response 39 14 22 20 32 Complete response 2 0 0 0 1 No response 48 15 15 27 37
P‐170: Color Writable Cholesteric Liquid Crystal Display and its Operation Principle (2008)

Abstract Color Writable Cholesteric Liquid Crystal Display (CHLCD) and its operation principle were developed. By applying strong‐enough electric field (ex: ±10V/100Hz square wave for 4um cell gap) to specific pixels, we could choose the color and directly write it to color CHLCD, because the pressure we released was canceled by the electric field. By applying appropriate electric field and/or pressure, gray levels could be achieved. In the application that we wrote a different color to CHLCD on which a written color existed, the electric field and the pressure had to be coordinated (ex: ±5.5V/10Hz, 1kgw/cm2), and other approaches were also proposed.
Experimental Identification of a Fractional Derivative Linear Model for Viscoelastic Materials (2005)

Non integer, fractional order derivative rheological models are known to be very effective in describing the linear viscoelastic dynamic behaviour of mechanical structures made of polymers. The application of fractional calculus to viscoelasticity can be physically consistent and the resulting non integer order differential stress-strain constitutive relation provides good curve fitting properties, requires only a few parameters and leads to causal behaviour. &#13;\nWhen using such models the solution of direct problems, i.e. the evaluation of time or frequency response from a known excitation can still be obtained from the equations of motion using standard tools such as modal analysis. But regarding the inverse problem, i.e. the identification from measured input-output vibrations, no general technique has so far been established, since the current methods do not seem to easily work with differential operators of non integer order.&#13;\nIn this paper a frequency domain method is proposed for the experimental identification of a linear viscoelastic model, namely the Fractional Zener also known as Fractional Standard Linear Solid, to compute the frequency dependent complex stress-strain relationship parameters related to the material. The procedure is first checked with respect to numerically generated frequency response functions for testing its accuracy, and then to experimental inertance data from a free-free homogeneous beam made of High Density Polyethylene (HDPE) in plane flexural and axial vibration.
Molecular Basis of Neurotrophin—Receptor Interactions (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Molecular consideration in selection of composite insulating materials and insulation systems (1960)

To many engineers not directly concerned with the more basic theories of dielectrics behavior, and, it must be recognized, even to some persons having a good knowledge of the electrical properties of individual insulating materials, it is often difficult to understand the detailed behavior of any particular insulation system. In other papers of this tutorial session, eminent speakers, well versed in their fields, have outlined the various fundamental relationships governing the properties of materials as related to structure of the individual materials, and it is the purpose of this paper to discuss briefly some of the phenomena which arise when combinations of insulating materials are used in more practical situations, and to focus discussion on how these phenomena can be related to basic relationships already established. With this more detailed understanding, it is also possible to see what advances can be made, and in what direction, for future development work in improved composite dielectric materials and insulation systems generally.
Concurrent opioid and benzodiazepine use after breast cancer diagnosis. (2019)

28 Background: Benzodiazepines contribute to one-third of opioid overdose deaths in the U.S. Guidelines caution against co-prescribing these two drug classes. Although patients with cancer commonly experience pain and anxiety, no studies have assessed trends in concurrent opioid/benzodiazepine use after cancer diagnosis. Our study examined trends in, and predictors of concurrent opioid/benzodiazepine use in older women diagnosed with breast cancer. Methods: We conducted a retrospective cohort analysis using 2012-2016 SEER-Medicare data for women diagnosed with stage 0-III breast cancer who had no concurrent opioid/benzodiazepine use in the 3 months prior to diagnosis. Using modified Poisson regression, we estimated the adjusted probability of concurrent use (≥1 day of overlapping opioid/benzodiazepine supply) in the 12 months post-diagnosis for patients diagnosed in each calendar quarter from Q2:2013 to Q4:2015. We also estimated the overall relative risk (RR) of concurrent use associated with patient demographic and clinical characteristics. Results: Among the 19, 267 women in our cohort, the quarterly adjusted probabilities of concurrent use were stable over time, ranging from 12% to 15%. Risk of concurrent use decreased with age but increased with cancer stage. Prior opioid use and prior benzodiazepine use increased the risk of concurrent use in the 12 months post-diagnosis (RR prior vs. no prior opioids = 2.57, 95% CI = 2.27-2.92; RR prior vs. no prior benzodiazepines = 15.05, 95% CI = 13.19-17.19). Women who underwent mastectomy (vs. no or minimal surgery) were 71% more likely to have concurrent use (RR = 1.71, 95% CI = 1.40-2.10). Similarly, women who received chemotherapy (vs. no chemotherapy) were 28% more likely to have concurrent use (RR = 1.28, 95% CI = 1.07-1.54). Finally, Black women (vs. White women) were 38% less likely to have concurrent use (RR = 0.62, 95% CI = 0.50-0.76). Conclusions: Up to 1 in 8 older women diagnosed with breast cancer exhibited concurrent opioid/benzodiazepine use in the 12 months after diagnosis. Clinicians must be mindful of exposing patients to this high-risk combination during cancer and survivorship care, particularly among patients with more intensive cancer treatment or prior use of either drug.
Validation of a New Quality of Life Questionnaire for Acute Migraine Headache (1995)

A brief migraine-specific quality of life questionnaire was developed to assess the quality of life decrement associated with an acute migraine attack in the 24-hour period following headache onset. The migraine quality of life questionnaire has 15 questions across five domains (work functioning, social functioning, energy, concerns, and symptoms). A prospective, observational study was conducted to evaluate the characteristics of internal consistency, construct and discriminant validity, and responsiveness of the migraine quality of life questionnaire. One hundred thirty-eight subjects with migraine were recruited. One hundred seven subjects completed a baseline and a 24-hour postmigraine quality of life questionnaire, along with a migraine diary for recording headache severity, activity limitation, associated symptoms, duration of headache, and use of migraine medication. All five migraine quality of life questionnaire domains showed good internal consistency (Cronbach's alpha, 0.74-0.95). The strongest correlations were seen between activity limitation and associated symptoms and the migraine quality of life questionnaire work, social, and energy domains. Significant differences in mean questionnaire scores between subjects were found with frequency of medication use, global change in symptoms, headache duration, and severity. All five domains showed significant responses within subjects from a migraine-free period to an acute migraine period (P < 0.0001). In summary, the migraine quality of life questionnaire showed good internal consistency, construct and discriminant validity, and responsiveness to acute migraine attacks.
Fundamental Characterization of Turbocharger Turbine Unsteady Flow Behavior (2007)

Fluid flow in the volute of a turbocharger turbine can be decidedly unsteady due to the pulsating nature of the exhaust gas in the manifolds of an internal combustion engine. Despite this it is conventional to use a quasi-steady or “filling and emptying” technique to model the turbine in one-dimensional turbocharged engine simulations. Depending on the inherent level of unsteadiness, this approach may be insufficient to capture the true turbine operation since neither method is able to resolve unsteady effects due to the presence of any wave action in the flow. Building on previously reported work, this paper aims to establish a measure of unsteadiness that takes account of the attributes of engine exhaust gas flow that give rise to gas dynamic unsteadiness. This characterization is achieved by decomposing the pulse into its constituent frequencies using Fourier analysis. A one-dimensional wave action code, featuring a bespoke boundary condition that permits application of a pressure pulse in Fourier series form, is used to investigate the effect of the contributing variables for some simplified cases. This allows the construction of the correct form of dimensionless parameter. Finally, the new dimensionless measures, the Fourier series Strouhal and acoustic Strouhal numbers (FSt and FaSt respectively), are evaluated at different test conditions to establish criteria for the transition from a filling and emptying mode to gas dynamic operation. The analysis suggests limiting values of FSt≤0.15, and FaSt≤0.02, to be used as an approximate guide for turbine model selection.
Measuring performance, power, and temperature from real processors (2007)

The modeling of power and thermal behavior of processors requires challenging validation processes, which may be complex and undependable. In order to ameliorate some of the difficulties associated with the validation of power and thermal models, this paper describes an infrared measurement setup that simultaneously captures run-time power consumption, thermal characteristics, and performance activity counters from modern processors. We use infrared cameras with high spatial resolution (10x10/μm) and high frame rate (125Hz) to capture thermal maps. Power measurements are obtained with a multimeter, while performance counters are obtained after modifying the operating system (Linux), both at a sampling rate of 1KHz. The synchronized traces can then be used in the validation process of possible thermal, power, and processor activity models.
Human cord blood-derived large myeloid cells: spontaneous shape change and chemotactic movement. (1996)

We have demonstrated two aspects of the movement of large myeloid cells derived from cord blood mononuclear cells after culture in RPMI 1640 and 10% fetal calf serum for eight days. At this time cells assume various shapes including round, oval, veiled, elongated and dendritic. Interestingly, these shapes were not static. Time-lapse recording demonstrated that individual cells change shape quite dramatically over four hours. Some of the veils showed a great deal of activity, some elongated cells shrank into rounded forms, and rounded cells stretched out into dendritic cells or elongated forms. We have previously shown that the number of N-formyl-methionine-leucyl-phenylalanine receptors on the cell surface increase with culture time up to eight days. Furthermore, a rise in Ca2+ was observed in response to 1 mumol/L N-formyl-methionine-leucyl- phenylalanine (chemotactic peptide) at the single cell level. In this paper we show the motility of cord blood-derived myeloid cells towards a chemotactic peptide concentration gradient leaking from a micropipette.
Impact of Plasma and Diluted HF on a CoWP Material (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
A liquid-chromatographic analysis for ritalinic acid [alpha-phenyl-alpha-(2-piperidyl) acetic acid] in serum. (1979)

We describe a "high-performance" liquid-chromatographic assay for measuring ritalinic acid in 300 muL of serum. The procedure includes adsorption of ritalinic acid and internal standard (alpha,alpha-dimethyl-beta-emthylsuccinimide) from serum onto charcoal, from which both compounds are eluted with methanol. The methanol extract is evaporated, the residue dissolved in a 93/7 (by volume) mixture of potassium phosphate buffer (20 mmol/L, pH 3.8) and acetonitrile, and an aliquot of this solution is chromatographed. We used a mu-Bondapak C-18 column with the above-mentioned buffer system as mobile phase, a flow rate of 2.0 mL/min, and a column temperature of 40 degrees C. Ritalinic acid and internal standard are detected by their absorbance at 192 nm and quantitated by measuring peak heights. The procedure allows for the reliable analysis for ritalinic acid in serum at concentrations greater than 50 microgram/L. Analytical recoveries were greater than 73% and the method affords good day-to-day precision (CV, less than 12%).
INFLUENCE OF FIXATION ON THE VISUAL ACUITY (1934)

In ordinary use the eyes are never entirely at rest but are continually moving. The visual axes are constantly changing so that images of objects in the outside world are brought to lie on the macular region of each eye. In this way objects in the external world are seen in much the same manner as one feels the character of a surface by palpating it with a finger. By moving the finger over the surface the sensory endings of touch are stimulated to send up their message to the brain. In order to discriminate the finer details of an object, on the other hand, it has often been assumed that the image of an object must rest on the fovea, permitting the parts of the image to stimulate a definite pattern of cones. The term fixation is used in this connection to signify that under these conditions the
HLA-E inhibitor enhances the killing of neuroblastoma stem cells by co-cultured dendritic cells and cytokine-induced killer cells loaded with membrane-based microparticles. (2017)

Neuroblastoma stem cells (NSCs) can cause drug resistance and tumor recurrence. This study aimed to enhance the lytic effect of dendritic cells (DCs) co-cultured with cytokine-induced killer (CIK) cells. NSCs were obtained by suspension culture, and DC-CIK cells were loaded with extracted NSC membrane-based microparticles (MMPs) before evaluating the lytic effect of DC-CIK cells on NSCs. After inhibiting the function or expression of human leukocyte antigen-E (HLA-E) in NSCs by anti-HLA-E monoclonal antibody or siRNA, the DC-CIK cell lytic effect on NSCs was re-assessed. NSC nestin expression was high, but glial fibrillary acid protein expression and class IIIβ-tubulin-1 expression were low. Moreover, NSCs exhibited strong tumorigenic ability in nude mice. Loading DCs with NSC-derived MMPs induced the differentiation of DCs and CIK cells and enhanced the killing of NSCs by DC-CIK cells. Inhibiting the function or expression of HLA-E in NSCs further enhanced the cytolytic capability of DC-CIK cells loaded with NSC-derived MMPs. HLA-E inhibitor can enhance the killing of NSC by DC-CIK cells loaded with NSC-derived MMPs.