gebhart/patrepeval huggingface dataset:
General Auction-Theoretic Strategies for Distributed Partner Selection in Cooperative Wireless Networks (2010)

It is unrealistic to assume that all nodes in an ad hoc wireless network would be willing to participate in cooperative communication, especially if their desired Quality-of- Service (QoS) is achievable via direct transmission. An incentivebased auction mechanism is presented to induce cooperative behavior in wireless networks with emphasis on users with asymmetrical channel fading conditions. A single-object secondprice auction is studied for cooperative partner selection in singlecarrier networks. In addition, a multiple-object bundled auction is analyzed for the selection of multiple simultaneous partners in a cooperative orthogonal frequency-division multiplexing (OFDM) setting. For both cases, we characterize equilibrium outage probability performance, seller revenue, and feedback bounds. The auction-based partner selection allows winning bidders to achieve their desired QoS while compensating the seller who assists them. At the local level sellers aim for revenue maximization, while connections are drawn to min-max fairness at the network level. The proposed strategies for partner selection in self-configuring cooperative wireless networks are shown to be robust under conditions of uncertainty in the number of users requesting cooperation, as well as minimal topology and channel link information available to individual users.
The History of Mainstream Legal Thought (1982)

Published as Chapter 1 in The Politics of Law: A Progressive Critique, revised edition, David Kairys, ed.
An N-Path Switched-Capacitor Rectifier for Piezoelectric Energy Harvesting Achieving 13.9× Power Extraction Improvement (2020)

This paper presents an N-path switched-capacitor rectifier which is capable of realizing staircase conjugate impedance matching, without the use of inductors, to maximize the power transfer from a piezoelectric transducer. Measurements of the 0.18μm CMOS prototype demonstrate 13.9× improvement in extracted power compared to an ideal full-bridge rectifier.
Assessment of White Matter Injury and Outcome in Severe Brain Trauma (2012)

White matter assessment with quantitative DTI increases the accuracy of long-term outcome prediction compared with the available clinical/radiographic prognostic score.
Rapid manufacturing techniques in the development of an axial blood pump impeller (2003)

This paper presents a comparison of manufacturing techniques used in the development of an axial blood pump impeller. In this development process the impeller was designed and its performance was evaluated with the aid of computational fluid dynamics (CFD). Prototypes of those designs where the CFD results show promise were needed in sufficient quantities at a low cost for experimental validation of the CFD results. As the impeller is less than 16 mm in diameter with a maximum blade thickness of about 1.5 mm, innovative manufacturing techniques are explored in this paper to determine the best process for quick fabrication of prototypes that are dimensionally accurate, structurally robust and low in cost. Four rapid prototyping techniques were explored. The completed parts were compared on the basis of manufacturing time, quality and strength of parts obtained, manufacturing cost and also in vitro performances. Based on these studies, it was concluded that selective laser sintering (SLS) is the most appropriate method for the quick production of prototype parts for evaluation of pump performance.
Entity-aware ELMo: Learning Contextual Entity Representation for Entity Disambiguation (2019)

We present a new local entity disambiguation system. The key to our system is a novel approach for learning entity representations. In our approach we learn an entity aware extension of Embedding for Language Model (ELMo) which we call Entity-ELMo (E-ELMo). Given a paragraph containing one or more named entity mentions, each mention is first defined as a function of the entire paragraph (including other mentions), then they predict the referent entities. Utilizing E-ELMo for local entity disambiguation, we outperform all of the state-of-the-art local and global models on the popular benchmarks by improving about 0.5\% on micro average accuracy for AIDA test-b with Yago candidate set. The evaluation setup of the training data and candidate set are the same as our baselines for fair comparison.
Formal Verification of Partial Good Self-Test Fencing Structures (2007)

The concept of applying partial fencing to logic built-in self test (LBIST) hardware structures for the purpose of using partially good chips is well known in the chip design industry. Deceptively difficult though is the task of verifying that any particular implementation of partial fencing logic actually provides the desired behavior of blocking down-stream impact of all signals from fenced interfaces, and also ensuring that the partial fencing does not inadvertently preclude any common logic from being fully tested. In this paper we discuss a case study for a verification method which exploits the power of formal verification to prove that any given partial fencing design satisfies all behavioral expectations. We describe the details of the verification method and discuss the benefits of using this approach versus using traditional simulation methods. We also discuss the testbenches created as part of applying this new method. Furthermore, we discuss the formal verification algorithms that were employed during application of the method along with the tuning that was done to enable efficient completion of the verification tasks at hand.
Differences in cortico‐striatal‐cerebellar activation during working memory in syndromal and nonsyndromal children with prenatal alcohol exposure (2012)

Although children with heavy prenatal alcohol exposure may exhibit the distinctive facial dysmorphology seen in full or partial fetal alcohol syndrome (FAS/PFAS), many lack that dysmorphology. This study examined the functional organization of working memory in the brain in three groups of children-those meeting diagnostic criteria for FAS or PFAS, heavily exposed (HE) nonsyndromal children, and healthy controls. A verbal n-back task (1-back and 0-back) was administered to 47 children (17 with FAS/PFAS, 13 HE, and 17 controls) during fMRI. Intra-group one-sample t-tests were used to identify activity regions of interest central to verbal working memory including the dorsal prefrontal cortex (dPFC), inferior frontal gyrus, caudate/putamen, parietal cortex, and cerebellar Crus I/lobule VI and lobule VIIB-IX. Whereas groups did not differ in task sensitivity, fMRI analyses suggested different patterns of sub-network recruitment across groups. Controls primarily recruited left inferior frontal gyrus (Broca's area). By contrast, HE primarily recruited an extensive set of fronto-striatal regions, including left dPFC and left caudate, and the FAS/PFAS group relied primarily on two cerebellar subregions and parietal cortex. This study is, to our knowledge, the first to demonstrate differential recruitment of critical brain regions that subserve basic function in children with different fetal alcohol spectrum disorders compared to controls. The distinct activation patterns seen in the two exposed groups may be related to substantial differences in alcohol dose/occasion to which these groups were exposed in utero.
PHOSPHONIC SYSTEMS. 6. DIETHYL 2-METHYLPENTENYLPHOSPHONATES AS A MODEL FOR STUDIES OF THE STABILITY OF UNSATURATED PHOSPHONIC ESTERS (1991)

Abstract The composition of a thermodynamically controlled mixture of diethyl esters of α,β and β,γ-unsaturated phosphonates was determined by NMR spectroscopy and gas chromatography. The location of the double bond is determined by alkyl substitution and by hyperconjugation, but not by the position of the phosphorus-containing group Key Words: Alkenylphosphonatesprototropic equilibria
An Innovative Understanding of Metal–Insulator–Metal (MIM)-Capacitor Degradation Under Constant-Current Stress (2007)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> This paper provides a new understanding of metal–insulator–metal-capacitor-degradation behavior under a wide range of constant-current-stress conditions. It was found that capacitance degrades with stress, but the behavior of the degradation strongly depends on the stress-current density. At high stress levels, the capacitance increases logarithmically as the injection charge increases until dielectric breakdown occurs. At lower stress conditions, the degradation rate is proportional to the stress current and reverses after a certain period of time. A metal-insulator interlayer is observed using cross-sectional transmission-electron-microscopy micrographs, which possibly explains this reversal phenomenon. </para>
Novel 18F-Labeled α-Methyl-Phenylalanine Derivative with High Tumor Accumulation and Ideal Pharmacokinetics for Tumor-Specific Imaging (2019)

Positron emission tomography (PET) imaging with <sup>18</sup>F-labeled α-methyl-substituted amino acids exerts significant influence on differential diagnosis of malignant tumors and tumor-like lesions. Exclusive uptake via L-type amino acid transporter 1 (LAT1), a tumor-specific transporter, accounts for their excellent tumor specificity and low background accumulation. However, further refinement and optimization in their tumor accumulation and pharmacokinetics are sorely needed. To address these issues, we newly designed <sup>18</sup>F-labeled α-methyl-phenylalanine (<sup>18</sup>F-FAMP) regioisomers (2-, 3-, or 4-<sup>18</sup>F-FAMP) and stereoisomers (L- or D-form), and we comprehensively evaluated their potential as tumor-imaging agents. <sup>18</sup>F-FAMPs were prepared from α-methyl phenylalanine by electrophilic radiofluorination and purified by reversed-phase HPLC. In biodistribution studies on normal mice, L-2-<sup>18</sup>F-FAMP and the three D-<sup>18</sup>F-FAMPs showed faster blood clearance and lower renal accumulation than L-3-<sup>18</sup>F-FAMP or L-4-<sup>18</sup>F-FAMP. In LS180 human colorectal cancer cell line xenograft mice, L-2-<sup>18</sup>F-FAMP exhibited significantly higher tumor accumulation than the D-<sup>18</sup>F-FAMPs or a clinically relevant tracer, L-3-<sup>18</sup>F-α-methyl-tyrosine (<sup>18</sup>F-FAMT) (<i>p</i> < 0.05). The renal accumulation levels of L-2-<sup>18</sup>F-FAMP were significantly lower than that of <sup>18</sup>F-FAMT (<i>p</i> < 0.01). LAT-1 specificity of L-2-<sup>18</sup>F-FAMP was validated in the cellular uptake studies. The PET imaging with L-2-<sup>18</sup>F-FAMP clearly visualized the tumor as early as 1 h after injection, and the high tumor accumulation level was retained for 3 h. These findings suggest that L-2-<sup>18</sup>F-FAMP constitutes a potential PET tracer for tumor-specific imaging.
Wofür wir stehen: die Werte der GDCh (2020)

Abstract Ein kontroverser Beitrag in der Angewandten Chemie und seine Folgen.
Aeroacoustic Wind Tunnel Tests of Wind Turbine Airfoils (2004)

Aeroacoustic wind tunnel tests were performed for six airfoils that are candidates for use on small wind turbines. One additional airfoil (NACA 0012) was tested for comparison to benchmark data. The acoustic measurements were performed in NLR's Small Anechoic Wind Tunnel, for a range of wind speeds ( U) and angles of attack, with and without boundary layer tripping. Besides the airfoil self-noise measurements in a clean tunnel flow, the models were also tested with a turbulence grid in the nozzle, to investigate airfoil noise associated with inflow turbulence. A 48-microphone out-of-flow acoustic array was used to locate noise sources and to separate airfoil noise from extraneous wind tunnel noise. Special techniques were applied to translate acoustic source plots to absolute airfoil noise spectra. The acoustic results indicate that in a clean tunnel flow trailing edge noise is dominant for all airfoils. In the untripped condition a number of airfoils exhibit intense tones, that disappear after proper tripping is applied. Broadband trailing edge noise levels are found to scale with U 4.5 . The agreement with the benchmark data was generally good. In case of inflow turbulence, leading edge noise is dominant for all airfoils, and no difference is observed between results with and without tripping. The inflow turbulence noise levels are found to scale with U 6 . Comparison of the acoustic results for different airfoils indicates that inflow turbulence noise levels increase with increasing sharpness of the model leading edge. The directivity of both trailing edge and inflow turbulence noise is found to be symmetrical with respect to the chord. With regard to the test set-up, it was found that a treatment of porous material at the model-endplate junctions yields a reduction of broadband extraneous noise up to 10 dB. As a result, the array can look much 'deeper', which enables the detection of very low trailing edge noise levels.
Hybrid parallelization strategies for large-scale machine learning in SystemML (2014)

SystemML aims at declarative, large-scale machine learning (ML) on top of MapReduce, where high-level ML scripts with R-like syntax are compiled to programs of MR jobs. The declarative specification of ML algorithms enables---in contrast to existing large-scale machine learning libraries---automatic optimization. SystemML's primary focus is on data parallelism but many ML algorithms inherently exhibit opportunities for task parallelism as well. A major challenge is how to efficiently combine both types of parallelism for arbitrary ML scripts and workloads. In this paper, we present a systematic approach for combining task and data parallelism for large-scale machine learning on top of MapReduce. We employ a generic Parallel FOR construct (ParFOR) as known from high performance computing (HPC). Our core contributions are (1) complementary parallelization strategies for exploiting multi-core and cluster parallelism, as well as (2) a novel cost-based optimization framework for automatically creating optimal parallel execution plans. Experiments on a variety of use cases showed that this achieves both efficiency and scalability due to automatic adaptation to ad-hoc workloads and unknown data characteristics.
Supplementary Results from A Bispecific Antibody-IFNα2b Immunocytokine Targeting CD20 and HLA-DR Is Highly Toxic to Human Lymphoma and Multiple Myeloma Cells (2023)

Supplementary Results from A Bispecific Antibody-IFNα2b Immunocytokine Targeting CD20 and HLA-DR Is Highly Toxic to Human Lymphoma and Multiple Myeloma Cells
Silencing of Neuroligin Function by Postsynaptic Neurexins (2007)

The formation of neuronal circuits during development involves a combination of synapse stabilization and elimination events. Synaptic adhesion molecules are thought to play an important role in synaptogenesis, and several trans-synaptic adhesion systems that promote the formation and maturation of synapses have been identified. The neuroligin-neurexin complex is a heterophilic adhesion system that promotes assembly and maturation of synapses through bidirectional signaling. In this protein complex, postsynaptic neuroligins are thought to interact trans-synaptically with presynaptic neurexins. However, the subcellular localization of neurexins has not been determined. Using immunoelectron microscopy, we found that endogenous neurexins and epitope-tagged neurexin-1beta are localized to axons and presynaptic terminals in vivo. Unexpectedly, neurexins are also abundant in the postsynaptic density. cis-expression of neurexin-1beta with neuroligin-1 inhibits trans-binding to recombinant neurexins, blocks the synaptogenic activity of neuroligin-1, and reduces the density of presynaptic terminals in cultured hippocampal neurons. Our results demonstrate that the function of neurexin proteins is more diverse than previously anticipated and suggest that postsynaptic cis-interactions might provide a novel mechanism for silencing the activity of a synaptic adhesion complex.
Concept, synthèse et mécanisme d'action de motifs hétéroaromatiques à visée radiochimiothérapeutique interne du mélanome (2005)

Le risque de développer un mélanome augmente fortement d'année en année. A partir de cette constatation, notre travail a consisté à la synthèse de molécules pouvant être utilisées en radiochimiothérapie interne du mélanome. Notre recherche s'est d'abord articulée sur une bibliographie récente montrant que des structures de type iodobenzamides ont été développées dans une finalité de radiothérapie. Une pharmacomudulation par substitution du noyau benzènique par un hétérocycle a été envisage e. Deux stratégies ont été réalisées soit à partir d'hétérocycles originaux soit à partir d'un motif acridine (ou acridone) reconnu comme cytotoxique. La 1ère approche a mis en jeu divers polyhétérocycles obtenus par réaction de Friedländer sur le synthon imidazopyridinique. Une évaluation de la cytotoxicité puis des études RMN d'intercalation avec un oligonucléotide de synthèse ont été effectuées. La seconde approche s'est principalement orientée vers la synthèse de iodoacridines et acridones carboxamides analogues du DACA et de l'amsacrine. Une détermination des valeurs d'IC50 de ces composés a été entreprise afin d'évaluer leur cytotoxicité vis-à vis du mélanome. Cette recherche, réalisée au sein de l'UMR INSERM 484 et à l'interface chimie-biologie, sera prolongée par des études de biodistribution.
Corruption of dendritic cell antigen presentation during acute GVHD leads to regulatory T-cell failure and chronic GVHD (2016)

Chronic graft-versus-host disease (cGVHD) is a major cause of late mortality following allogeneic bone marrow transplantation (BMT) and is characterized by tissue fibrosis manifesting as scleroderma and bronchiolitis obliterans. The development of acute GVHD (aGVHD) is a powerful clinical predictor of subsequent cGVHD, suggesting that aGVHD may invoke the immunologic pathways responsible for cGVHD. In preclinical models in which sclerodermatous cGVHD develops after a preceding period of mild aGVHD, we show that antigen presentation within major histocompatibility complex (MHC) class II of donor dendritic cells (DCs) is markedly impaired early after BMT. This is associated with a failure of regulatory T-cell (Treg) homeostasis and cGVHD. Donor DC-restricted deletion of MHC class II phenocopied this Treg deficiency and cGVHD. Moreover, specific depletion of donor Tregs after BMT also induced cGVHD, whereas adoptive transfer of Tregs ameliorated it. These data demonstrate that the defect in Treg homeostasis seen in cGVHD is a causative lesion and is downstream of defective antigen presentation within MHC class II that is induced by aGVHD.
Immunotherapy and Prevention of Cancer by Nanovaccines Loaded with Whole‐Cell Components of Tumor Tissues or Cells (2021)

Tumor tissues/cells are the best sources of antigens to prepare cancer vaccines. However, due to the difficulty of solubilization and delivery of water-insoluble antigens in tumor tissues/cells, including water-insoluble antigens into cancer vaccines and delivering such vaccines efficiently to antigen-presenting cells (APCs) remain challenging. To solve these problems, herein, water-insoluble components of tumor tissues/cells are solubilized by 8 m urea and thus whole components of micrometer-sized tumor cells are reasssembled into nanosized nanovaccines. To induce maximized immunization efficacy, various antigens are loaded both inside and on the surface of nanovaccines. By encapsulating both water-insoluble and water-soluble components of tumor tissues/cells into nanovaccines, the nanovaccines are efficiently phagocytosed by APCs and showed better therapeutic efficacy than the nanovaccine loaded with only water-soluble components in melanoma and breast cancer. Anti-PD-1 antibody and metformin can improve the efficacy of nanovaccines. In addition, the nanovaccines can prevent lung cancer (100%) and melanoma (70%) efficiently in mice. T cell analysis and tumor microenvironment analysis indicate that tumor-specific T cells are induced by nanovaccines and both adaptive and innate immune responses against cancer cells are activated by nanovaccines. Overall, this study demonstrates a universal method to make tumor-cell-based nanovaccines for cancer immunotherapy and prevention.
Novel repumping on 3P0 → 3D1 for Sr magneto-optical trap and Landé g factor measurement of 3D1 (2020)

Abstract We realize an experimental facility for cooling and trapping strontium (Sr) atoms and measure the Landé g factor of 3 D 1 of 88 Sr. Thanks to a novel repumping scheme with the 3 P 2 → 3 S 1 and 3 P 0 → 3 D 1 combination and the permanent magnets based self-assembled Zeeman slower, the peak atom number in the continuously repumped blue magneto-optical trap is enhanced by a factor of 15 with respect to the non-repumping case, and reaches ∼1 billion. Furthermore, using the resolved-sideband Zeeman spectroscopy, the Landé g factor of 3 D 1 is measured to be 0.4995(88) showing a good agreement with the theoretical value of 0.4988. The results will have an impact on various applications including atom laser, dipolar interactions, quantum information and precision measurements.
On P vs. NP, Geometric Complexity Theory, and the Flip I: a high level view (2007)

Geometric complexity theory (GCT) is an approach to the $P$ vs. $NP$ and related problems through algebraic geometry and representation theory. This article gives a high-level exposition of the basic plan of GCT based on the principle, called the flip, without assuming any background in algebraic geometry or representation theory.
Intramolecular cobalt-mediated [2 + 2 + 2] cycloaddition of linear enediynes. A useful synthetic entry into cobalt-protected tricyclic dienes and their synthetic elaboration (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIntramolecular cobalt-mediated [2 + 2 + 2] cycloaddition of linear enediynes. A useful synthetic entry into cobalt-protected tricyclic dienes and their synthetic elaborationEthan D. Sternberg and K. Peter C. VollhardtCite this: J. Org. Chem. 1984, 49, 9, 1564–1573Publication Date (Print):May 1, 1984Publication History Published online1 May 2002Published inissue 1 May 1984https://pubs.acs.org/doi/10.1021/jo00183a017https://doi.org/10.1021/jo00183a017research-articleACS PublicationsRequest reuse permissionsArticle Views384Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Synthesis of Amino 1,3-Diols. Ring Opening of N-Acyl Activated Lactams with Carbon Nucleophiles (1993)

Abstract A synthesis of 6-amino-7-cyclohexyl-3,5-heptanediol 1 (CDH) and related amino 1,3-diols involving a nucleophilic ring opening of N-acyl activated lactams is described. Stereochemical proof of the 1,3-diol moiety is also presented.