gebhart/patrepeval huggingface dataset:
Erg25 Controls Host-Cholesterol Uptake Mediated by Aus1p-Associated Sterol-Rich Membrane Domains in Candida glabrata (2022)

The uptake of cholesterol from the host is closely linked to the proliferation of pathogenic fungi and protozoa during infection. For some pathogenic fungi<i>,</i> cholesterol uptake is an important strategy for decreasing susceptibility to antifungals that inhibit ergosterol biosynthesis. In this study, we show that <i>Candida glabrata ERG25</i>, which encodes an enzyme that demethylates 4,4-dimethylzymosterol, is required for cholesterol uptake from host serum. Based on the screening of <i>C. glabrata</i> conditional knockdown mutants for each gene involved in ergosterol biosynthesis, <i>ERG25</i> knockdown was found to decrease lethality of infected mice. <i>ERG25</i> knockdown impairs the plasma membrane localization of the sterol importer Aus1p, suggesting that the accumulated 4,4-dimethylzymosterol destabilizes the lipid domain with which Aus1p functionally associates. <i>ERG25</i> knockdown further influences the structure of the membrane compartment of Can1p (MCC)/eisosomes (ergosterol-rich lipid domains), but not the localization of the membrane proteins Pma1p and Hxt1p, which localize to sterol-poor domains. In the sterol-rich lipid domain, Aus1p-contining domain was mostly independent of MCC/eisosomes, and the nature of these domains was also different: Ausp1-contining domain was a dynamic network-like domain, whereas the MCC/eisosomes was a static dot-like domain. However, deletion of MCC/eisosomes was observed to influence the localization of Aus1p after Aus1p was transported from the endoplasmic reticulum (ER) through the Golgi apparatus to the plasma membrane. These findings suggest that <i>ERG25</i> plays a key role in stabilizing sterol-rich lipid domains, constituting a promising candidate target for antifungal therapy.
The importance of fractional bandwidth in ultra-wideband pulse design (2003)

Ultra-wideband (UWB) communications systems provide extremely high data rates while using low transmit power relative to narrowband systems. Previous research concludes that such systems have characteristics that make them appropriate for high-speed wireless network applications. One of the distinguishing aspects of the UWB signal is an extremely high fractional bandwidth when compared with conventional narrowband systems. This paper describes how a large fractional bandwidth leads to lower worst-case fading in the presence of multipath for UWB communications systems, thereby providing a significant advantage for a low-power wireless systems. Also included are measurements made using an actual UWB communications systems showing the magnitude of signal strength variations due to multipath interference.
Repair of thumb degloving injuries by island flaps with pedicle of the first or second dorsal metacarpal artery (2007)

Objective To introduce the method of repairing thumb degloving injuries by island flaps with pedicle of the first or second dorsal metacarpal artery,Methods Nine thumbs of degloving injuries with intact neurovaseular bundle and nail beds were treated by island flaps with pedicle the of first or second metacarpal artery,Results All 9 island flaps survived,Seven cases were followed-up for 6 months to 4 years,The repaired thumbs, reconstructed nail grooves and nail folds, and donor sites all had satisfactory appearance,Nail growth was normal,Two-point discrimination ranged from 6 to 9 ram with an average of 8 mm.Flexion and extension of the thumb, index and middle fingers was normal,Retrieved to primary jobs,Conclusion Island flap based on pedicle of the first or second metacarpal artery is a good choice for treating degloving injuries of the thumb when the neurovascular bundle and nail bed is intact.
OC01.01: *Fetal neurosonography and infant′s neurobehavioural tests in assisted reproductive technologies following fresh and frozen embryo transfer (2021)

To explore and compare fetal neurosonography and infant neurobehavioural tests in spontaneously conceived (SC) and in vitro fertilisation (IVF) offspring. A prospective cohort study of 210 singleton pregnancies including 70 SC pregnancies, 70 conceived by IVF following frozen embryo transfer (ET) and 70 after fresh ET. Fetal neurosonography was performed at 32 ± 2 weeks to assess cortical development and corpus callosum length. Neurosonography measurements were normalized by biparietal or occipitofrontal diameters. Additionally, Ages & Stages Questionnaires (ASQ) were obtained postnatally, at 12 ± 1 months of corrected age. Comparisons were adjusted by maternal age, ethnicity, nulliparity, offspring′s gender, weight centile, age at evaluation, and for the ASQ, also by breastfeeding, maternal study level and employment status. Overall, as compared to SC fetuses, the IVF populations showed differences in cortical development with reduced parieto-occipital (fresh ET mean 12.5 mm [SD 2.5] vs frozen ET 13.4[2.6] vs SC 13.4[2.6], p < 0.001), cingulate (fresh ET 5.8[1.8] vs frozen ET 6.0[2.1] vs SC 6.4[1.9], p < 0.001) and calcarine (fresh ET 13.3[3.9] vs frozen ET 14.1[2.8] vs SC 16.1[2.7], p = <0.001) sulci depth together with lower Sylvian fissure grading. Cortical changes were more pronounced in the fresh ET group as compared to the frozen ET. Corpus callosum length was significantly lower in the frozen ET (fresh ET 40.1 mm[2.5] vs frozen ET 39.8[2.5] vs SC 40.2[2.3], p < 0.001). IVF infants showed lower ASQ scores, especially in the fresh ET group (global ASQ z-scores: fresh ET -0.3[0.4] vs frozen ET -0.2[0.4] vs SC 0[0.4], p < 0.001). Fetuses and infants conceived by IVF show a different pattern of cortical development with shorter corpus callosum associated to suboptimal infant neurodevelopment, with more pronounced changes in fresh ET. These findings support the existence of in utero brain reorganisation and warrant follow-up studies to assess their long-term persistence.
Pediatric & Congenital Electrophysiology Society: building an international paediatric electrophysiology organisation (2016)

The Pediatric and Congenital Electrophysiology Society (PACES) is a non-profit organisation comprised of individuals dedicated to improving the care of children and young adults with cardiac rhythm disturbances. Although PACES is a predominantly North American-centric organisation, international members have been a part of PACES for the last two decades. This year, PACES expanded its North American framework into a broadly expansive international role. On 12 May, 2015, paediatric electrophysiology leaders from within the United States of America and Canada met with over 30 international paediatric electrophysiologists from 17 countries and five continents discussing measures to (1) expand PACES' global vision, (2) address ongoing challenges such as limited resource allocation that may be present in developing countries, (3) expand PACES' governance to include international representation, (4) promote joint international sessions at future paediatric EP meetings, and (5) facilitate a global multi-centre research consortium. This meeting marked the inception of a formal international collaborative spirit in PACES. This editorial addresses some solutions to breakdown the continental silos paediatric electrophysiologists have practiced within; however, there remain ongoing limitations, and future discussions will be needed to continue to move the PACES global international vision forward.
A Data Partition Based Model to Enforce Security in Cloud Database (2014)

Cloud computing has brought many advantages to companies and computer users. It allows different service providers to distribute many applications as services in an economical way. Therefore, many users and companies have begun using cloud computing. However, they are concerned about their data when they store it on a third party, the cloud. Fears of leakage of sensitive data or loss of privacy make the adoption of cloud services less attractive for organizations. In this paper an algorithm is presented to protect a table in a database from any leakage. We have developed a model with a view to offer secure data management capability in cloud databases. The model distributes and scatters the data over the cloud or data center in order to protect it from any leakage. Two models have been designed to divide a table by attributes relationship and by depending on non-sensitive and sensitive data. Also, this paper explains the idea of sending the entire domain of the sensitive table into the cloud. In addition, to increase security, the algorithm is designed to store each sensitive data in a different table with a different code and store this code at the client site. Furthermore, a new technique has been designed to collect the data from the cloud by using the bipartite matching algorithm to minimize load costs.
Corneal-scleral melt in association with cataract surgery and intraocular lenses: A report of four cases (1990)

Four patients with rheumatoid arthritis had cataract extraction with implantation of an intraocular lens (IOL). Postoperatively three patients developed progressive scleromalacia perforans. All three cases required patch grafting of the sclera and two of them developed progressive melting of the sclera and graft. The fourth case involved progressive corneal melting with extrusion of the IOL despite treatment with penetrating keratoplasties. All four cases developed retinal detachments with loss of vision and three of the eyes were subsequently enucleated. We describe each case and discuss the clinicopathologic correlations of this condition. The need for careful evaluation of rheumatoid arthritis patients with cataract surgery and IOL implantation is emphasized.
Progress in Operations Research. Vols. 1 and 2 (1977)

"Progress in Operations Research. Vols. 1 and 2." Journal of the Operational Research Society, 28(3), pp. 753–754
ChemInform Abstract: t‐Butyldimethylsilyl Chloride Mediated Pummerer Reactions of 10‐Alkylsulfinylbornan‐2‐exo‐ols. (1990)

Abstract The compounds (I) undergo a Pummerer‐type rearrangement yielding mainly imidazoles (III) with TBMSCl and imidazole or, in the presence of TBMSCl and DMAP, a disulfide (V) and a thioacetal (IV), respectively.
Selective Disinfection Based on Directional Ultraviolet Irradiation and Artificial Intelligence (2021)

Ultraviolet disinfection has been proven to be effective for surface sanitation. Traditional ultraviolet disinfection systems generate omnidirectional radiation, which introduces safety concerns regarding human exposure. Large scale disinfection must be performed without humans present, which limits the time efficiency of disinfection. We propose and experimentally demonstrate a targeted ultraviolet disinfection system using a combination of robotics, lasers, and deep learning. The system uses a laser-galvo and a camera mounted on a two-axis gimbal running a custom deep learning algorithm. This allows ultraviolet radiation to be applied to any surface in the room where it is mounted, and the algorithm ensures that the laser targets the desired surfaces avoids others such as humans. Both the laser-galvo and the deep learning algorithm were tested for targeted disinfection.
Development of economical and sustainable cultivation system for biomass production and simultaneous treatment of municipal wastewater using Tetraselmis indica BDUG001 (2023)

Microalgal-based bioprocess offers several advantages including wastewater reclamations, therefore present study assessed the usability of the combination of untreated municipal sewage wastewater (UTMSWW) and secondary treated municipal sewage wastewater (STSWW) for nutrient removal and recovery by <i>Tetraselmis indica</i> (<i>T</i>. <i>indica</i>) BDUG001. The present study optimized the additional nutrient supplementations (e.g. ASN-III) percentage and day-night cycle, pH and pH with aeration for monitoring high-rate biomass production and nutrient recovery. The study results showed that the combination of 75% UTMSWW + 25% ASN-III supported maximum biomass production (2.65 ± 0.07 g/L). In the optimized day-night cycle (12:12 h), <i>T. indica</i> BDUG001 showed improved biomass production (2.75 ± 0.07 g/L), biomass productivity (165.63 ± 4.42 mg/L/d), and photosynthetic pigments production. Under optimized pH∼ 7.0 with aeration, maximum total nitrate (TN) removal efficiency (87.67 ± 3.08-91.55 ± 1.92%) was observed, while COD and TP removal was maximum at pH ∼ 9.0. The maximum biomass production (2.35 ± 0.07-2.77 ± 0.04 g/L) with biomass productivity (93.75 ± 167.19 ± 2.21 mg/L/d) and lipid content (42.98 ± 1.86-47.85 ± 0.21% DCW) were also at pH 7.0. with aeration. The present study verified the utilization of UTMSWW with the combination of conventional medium, optimized day-night cycle, pH with aeration along with designing low-cost PBR. It was the ideal system for the cultivation of <i>T. indica</i> BDUG001 for the recovery of nutrients from wastewater, production of biofuels and value-added feedstock.
Expression of stabilized β-catenin in differentiated neurons of transgenic mice does not result in tumor formation (2002)

No tumors or morphologic alterations were detected in the brains of transgenic mice expressing stabilized beta-catenin, suggesting that postnatal Wnt signaling in differentiated neurons may not be sufficient to induce CNS tumorigenesis.
Direct Observation of Molecular‐Level Template Action Leading to Self‐Assembly of a Porous Framework (2010)

The molecular steps involved in the self-assembly of Cu(3)(BTC)(2) (BTC=1,3,5-benzenetricarboxylic acid) metal-organic frameworks that enclose Keggin-type H(3)PW(12)O(40) heteropolyacid molecules were unraveled by using solution (17)O, (31)P, and (183)W NMR spectroscopy, small-angle X-ray scattering, near-IR spectroscopy, and dynamic light scattering. In aqueous solution, complexation of Cu(2+) ions with Keggin-type heteropolyacids was observed. Cu(2+) ions are arranged around the Keggin structure so that linking through benzenetricarboxylate groups results in the formation of the Cu(3)(BTC)(2) MOF structure HKUST-1. This is a unique instance in which a templating mechanism that relies on specific molecular-level matching and leads to explicit nanoscale building units can be observed in situ during formation of the synthetic nanoporous material.
Intrachannel nonlinear penalties in dispersion-managed transmission systems (2002)

We have developed a model for intra-channel impairments in dispersion-managed systems and validated it using numerical simulations. We have shown that intrachannel impairments can be reduced using optimal precompensation. We have studied the intrachannel penalty for different modulation formats, and results show that the optimum precompensation is independent of modulation format. The intrachannel penalty decreases as the spectrum of the modulation format broadens.
Single lung ventilation in children using a new paediatric bronchial blocker (2002)

As video-assisted thoracoscopic surgery has become more common in paediatric patients, the use of single lung ventilation in children has also increased. Single lung ventilation in young children is performed by either advancing a tracheal tube into the mainstem bronchus opposite the side of surgery or by positioning a bronchial blocker into the mainstem bronchus on the operative side. Techniques for placing a variety of bronchial blockers outside the tracheal tube have been described. We describe a technique for placement of a new bronchial blocker through an indwelling tracheal tube using a multiport adaptor and a fibreoptic bronchoscope.
Biometric Touch Sensing (2015)

Current touch devices separate user authentication from regular interaction, for example by displaying modal login screens before device usage or prompting for in-app passwords, which interrupts the interaction flow. We propose biometric touch sensing, a new approach to representing touch events that enables commodity devices to seamlessly integrate authentication into interaction: From each touch, the touchscreen senses the 2D input coordinates and at the same time obtains biometric features that identify the user. Our approach makes authentication during interaction transparent to the user, yet ensures secure interaction at all times. To implement this on today's devices, our watch prototype Bioamp senses the impedance profile of the user's wrist and modulates a signal onto the user's body through skin using a periodic electric signal. This signal affects the capacitive values touchscreens measure upon touch, allowing devices to identify users on each touch. We integrate our approach into Windows 8 and discuss and demonstrate it in the context of various use cases, including access permissions and protecting private screen contents on personal and shared devices.
Measuring Conductivity With Scanning Probe Microscopes (2002)

Abstract There are two kinds of conductivity measurements possible with scanning probe microscopy (SPM). In the first case, the specific resistance of material directly below the tip is probed. In the second case, SPM probes local potential induced by the lateral current applied through macroscopic contacts, thus providing the information on the mesoscopic transport properties of the sample. The first set of techniques is invariably based on measuring tip-surface current in contact or intermittent tapping mode. If the tip-surface contact resistance is small (good contact), the current will be limited by the spreading resistance of the sample from which specific resistance can be calculated, assuming that the contact area is known.
Zirconia based dental ceramics: structure, mechanical properties, biocompatibility and applications (2016)

Zirconia (ZrO<sub>2</sub>) based dental ceramics have been considered to be advantageous materials with adequate mechanical properties for the manufacturing of medical devices. Due to its very high compression strength of 2000 MPa, ZrO<sub>2</sub> can resist differing mechanical environments. During the crack propagation on the application of stress on the surface of ZrO<sub>2</sub>, a crystalline modification diminishes the propagation of cracks. In addition, zirconia's biocompatibility has been studied in vivo, leading to the observation of no adverse response upon the insertion of ZrO<sub>2</sub> samples into the bone or muscle. In vitro experimentation has exhibited the absence of mutations and good viability of cells cultured on this material leading to the use of ZrO<sub>2</sub> in the manufacturing of hip head prostheses. The mechanical properties of zirconia fixed partial dentures (FPDs) have proven to be superior to other ceramic/composite restorations and hence leading to their significant applications in implant supported rehabilitations. Recent developments were focused on the synthesis of zirconia based dental materials. More recently, zirconia has been introduced in prosthetic dentistry for the fabrication of crowns and fixed partial dentures in combination with computer aided design/computer aided manufacturing (CAD/CAM) techniques. This systematic review covers the results of past as well as recent scientific studies on the properties of zirconia based ceramics such as their specific compositions, microstructures, mechanical strength, biocompatibility and other applications in dentistry.
A new quality of service measure for cellular radio systems (1997)

A new "quality of service" (QoS) measure called rms excessive blocking, denoted as EB(2), is proposed as a composite measure of the blocking rate and the cell-to-cell variation of blocking rates. EB(2) belongs to a class of measures EB(p),p/spl ges/1, which is unbiased, makes reference to the QoS requirement, is one-sided, and takes on the form of a penalty function. The effectiveness of this rms excessive blocking measure is compared to the conventional mean plus a standard deviation type of measure and evaluated on two efficient dynamic channel-assignment strategies, namely, borrowing with directional channel-locking strategy and compact-pattern (CP)-based dynamic channel assignment (DCA),.
Routing and Quality of Service in Mobile AdHoc Networks with TORA/INORA (2002)

Mobile Adhoc NETworks(MANETs) are characterized by bandwidth constrainedlinks, multiple hops and dynamic topologies. Routing and providing qualityof service in these networks is a highly challenging task. In this thesis,we discuss the unicast routing in MANETs with enhancements to the Temporally OrderedRouting Algorithm(TORA) and quality of service at the network layer with INORA. Temporally Ordered Routing Algorithm (TORA) is a highly distributed, scalable routingprotocol for MANETs. We discuss the improvements in the performance of TORA by QueryLocalization. We also discuss the improvements to TORA to remove aspecific traffic instability problem in TORA. We also describe theproactive operation of TORA and show by simulations that it is generally a good idea to have thegateway nodes in a MANET proactively perform route building and route maintenance. We propose INORA, a network layer QoS support mechanism in adhoc networks, which makesuse of the INSIGNIA in-band signaling mechanism and TORA. We present aneffective couplingbetween TORA and INSIGNIA to get routes that are "best-able" to provide QoS requirementsfor a flow. INORA also provides congestion control. We present two schemes called"Coarse feedback scheme" and "Fine feedback scheme" under the INORA frame work. Weshow that under heavily loaded conditions, the INORA schemes perform better than whenthe signaling protocol and the routing protocol operate without feedback.
ChemInform Abstract: Synthesis of Carbohydrate‐Derived Acylsilanes. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Role of Halide Ions in Divalent Palladium‐Mediated Reactions: Competition Between β‐Heteroatom Elimination and β‐Hydride Elimination of a Carbon—Palladium Bond. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Supplementary Table 3 from A Gene Signature Predicting for Survival in Suboptimally Debulked Patients with Ovarian Cancer (2023)

Supplementary Table 3 from A Gene Signature Predicting for Survival in Suboptimally Debulked Patients with Ovarian Cancer
PRF-1150 1KW 13.56 MHz Class E RF Generator Evaluation Module (2002)

The PRF-1150 module is a self-contained 1KW 13.56MHz RF source. The module facilitates operation and evaluation of the DEIC420 RF MOSFET gate driver IC and DE275X2-102N06A RF MOSFET in a practical 13.56 MHz RF generator application. It is all-inclusive, pre-tested, and ready to operate.