gebhart/patrepeval huggingface dataset:
Combining Schwann Cell Bridges and Olfactory-Ensheathing Glia Grafts with Chondroitinase Promotes Locomotor Recovery after Complete Transection of the Spinal Cord (2005)

Numerous obstacles to successful regeneration of injured axons in the adult mammalian spinal cord exist. Consequently, a treatment strategy inducing axonal regeneration and significant functional recovery after spinal cord injury has to overcome these obstacles. The current study attempted to address multiple impediments to regeneration by using a combinatory strategy after complete spinal cord transection in adult rats: (1) to reduce inhibitory cues in the glial scar (chondroitinase ABC), (2) to provide a growth-supportive substrate for axonal regeneration [Schwann cells (SCs)], and (3) to enable regenerated axons to exit the bridge to re-enter the spinal cord (olfactory ensheathing glia). The combination of SC bridge, olfactory ensheathing glia, and chondroitinase ABC provided significant benefit compared with grafts only or the untreated group. Significant improvements were observed in the Basso, Beattie, and Bresnahan score and in forelimb/hindlimb coupling. This recovery was accompanied by increased numbers of both myelinated axons in the SC bridge and serotonergic fibers that grew through the bridge and into the caudal spinal cord. Although prominent descending tracts such as the corticospinal and reticulospinal tracts did not successfully regenerate through the bridge, it appeared that other populations of regenerated fibers were the driving force for the observed recovery; there was a significant correlation between numbers of myelinated fibers in the bridge and improved coupling of forelimb and hindlimb as well as open-field locomotion. Our study tests how proven experimental treatments interact in a well-established animal model, thus providing needed direction for the development of future combinatory treatment regimens.
Combinatorial glucose, nicotinic acid and N-acetylcysteine therapy has synergistic effect in preclinicalC. elegansand zebrafish models of mitochondrial complex I disease (2021)

Mitochondrial respiratory chain disorders are empirically managed with variable antioxidant, cofactor and vitamin 'cocktails'. However, clinical trial validated and approved compounds, or doses, do not exist for any single or combinatorial mitochondrial disease therapy. Here, we sought to pre-clinically evaluate whether rationally designed mitochondrial medicine combinatorial regimens might synergistically improve survival, health and physiology in translational animal models of respiratory chain complex I disease. Having previously demonstrated that gas-1(fc21) complex I subunit ndufs2-/-C. elegans have short lifespan that can be significantly rescued with 17 different metabolic modifiers, signaling modifiers or antioxidants, here we evaluated 11 random combinations of these three treatment classes on gas-1(fc21) lifespan. Synergistic rescue occurred only with glucose, nicotinic acid and N-acetylcysteine (Glu + NA + NAC), yielding improved mitochondrial membrane potential that reflects integrated respiratory chain function, without exacerbating oxidative stress, and while reducing mitochondrial stress (UPRmt) and improving intermediary metabolic disruptions at the levels of the transcriptome, steady-state metabolites and intermediary metabolic flux. Equimolar Glu + NA + NAC dosing in a zebrafish vertebrate model of rotenone-based complex I inhibition synergistically rescued larval activity, brain death, lactate, ATP and glutathione levels. Overall, these data provide objective preclinical evidence in two evolutionary-divergent animal models of mitochondrial complex I disease to demonstrate that combinatorial Glu + NA + NAC therapy significantly improved animal resiliency, even in the face of stressors that cause severe metabolic deficiency, thereby preventing acute neurologic and biochemical decompensation. Clinical trials are warranted to evaluate the efficacy of this lead combinatorial therapy regimen to improve resiliency and health outcomes in human subjects with mitochondrial disease.
Optimizing jammer model against PPM UWB non-coherent receiver (2011)

Jamming is a major threat against wireless communications. In this paper, we evaluate the effect of jamming on an UWB link employing a PPM non-coherent receiver. We optimize the jammer parameters that are the central frequency and the bandwidth based on the metric of the signal-to-jamming ratio. The optimization depends on different system parameters such as the channel model and the integration time of the receiver.
176: Efficacy, Safety, and Tolerability of Fesoterodine in Patients with Overactive Bladder: A Phase 3 Placebo Controlled Trial in the United States (2006)

You have accessJournal of UrologyDiscussed Poster, Sunday, May 21, 2006, 9:00 am - 12:00 pm1 Apr 2006176: Efficacy, Safety, and Tolerability of Fesoterodine in Patients with Overactive Bladder: A Phase 3 Placebo Controlled Trial in the United States Victor W. Nitti, Roger R. Dmochowski, Troy Williams, and Orestes R. Alvarez-Jacinto Victor W. NittiVictor W. Nitti More articles by this author , Roger R. DmochowskiRoger R. Dmochowski More articles by this author , Troy WilliamsTroy Williams More articles by this author , and Orestes R. Alvarez-JacintoOrestes R. Alvarez-Jacinto More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)32443-1AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "176: Efficacy, Safety, and Tolerability of Fesoterodine in Patients with Overactive Bladder: A Phase 3 Placebo Controlled Trial in the United States." The Journal of Urology, 175(4S), p. 57 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 175Issue 4SApril 2006Page: 57 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Victor W. Nitti More articles by this author Roger R. Dmochowski More articles by this author Troy Williams More articles by this author Orestes R. Alvarez-Jacinto More articles by this author Expand All Advertisement PDF DownloadLoading ...
Experimental combined aflatoxin B1 and ochratoxin A intoxication in pigs (1985)

Twenty-one pigs weighing approximately 18 kg were placed in 7 groups of 3 and given diets containing respectively aflatoxin B1 alone at 0.375 and 0.0750 mg/kg, ochratoxin A alone at 1 and 2 mg/kg, 0.375 mg/kg of aflatoxin B1 plus 1 mg/kg of ochratoxin A and 0.750 mg/kg aflatoxin B1 and 2 mg/kg of ochratoxin A. The remaining group served as untreated control. At the respective dose levels, pigs receiving similar doses of ochratoxin A alone or in combination with aflatoxin B1, were similarly affected, the clinical effects of aflatoxin having been mostly obscured by those due to ochratoxin A. Mild degenerative hepatic changes typical of aflatoxicosis were observed in pigs fed this toxin alone or in combination with ochratoxin A. In kidneys of pigs fed diet containing 1 and 2 mg of ochratoxin A alone changes included interstitial fibrosis of the vortex and dystrophy and degeneration of the tubular epithelium. Similar lesions but less pronounced fibrosis were found in kidneys of pigs receiving both toxins. The respective lower dose levels of mycotoxins selected were judged to be about the no-effect levels for each dosed separately under the conditions of the trial. Such levels have been found not infrequently on mould affected grain and stock foods. The result highlights the difficulties that may be experienced in the recognition of such multimycotoxicoses as they are likely to occur in the field and indicate the need for toxicological analysis as well as pathological investigation in establishing a diagnosis.
A 240-Fold Electrostatic Rate-Enhancement for Acetylcholinesterase−Substrate Binding Can Be Predicted by the Potential within the Active Site (1996)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTA 240-Fold Electrostatic Rate-Enhancement for Acetylcholinesterase−Substrate Binding Can Be Predicted by the Potential within the Active SiteHuan-Xiang Zhou, James M. Briggs, and J. Andrew McCammonView Author Information Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay Kowloon, Hong Kong Departments of Chemistry and Biochemistry and Pharmacology, University of California at San Diego La Jolla, California 92093-0365 Cite this: J. Am. Chem. Soc. 1996, 118, 51, 13069–13070Publication Date (Web):December 25, 1996Publication History Received6 September 1996Published online25 December 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/ja963134ehttps://doi.org/10.1021/ja963134erapid-communicationACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views144Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Ionic strength,Kinetic parameters,Molecular mechanics,Peptides and proteins,Surface interactions Get e-Alerts
Electric-Field-Dependent Photoconductivity in CdS Nanowires and Nanobelts: Exciton Ionization, Franz–Keldysh, and Stark Effects (2012)

We report on the electric-field-dependent photoconductivity (PC) near the band-edge region of individual CdS nanowires and nanobelts. The quasi-periodic oscillations above the band edge in nanowires and nanobelts have been attributed to a Franz-Keldesh effect. The exciton peaks in PC spectra of the nanowires and thinner nanobelts show pronounced red-shifting due to the Stark effect as the electric field increases, while the exciton ionization is mainly facilitated by strong electron-longitudinal optical (LO) phonon coupling. However, the band-edge transition of thick nanobelts blue-shifts due to the field-enhanced exciton ionization, suggesting partial exciton ionization as the electron-LO phonon coupling is suppressed in the thicker belts. Large Stark shifts, up to 48 meV in the nanowire and 12 meV in the thinner nanobelts, have been achieved with a moderate electric field on the order of kV/cm, indicating a strong size and dimensionality implication due to confinement and surface depletion.
Contactless inter-tier communication for heterogeneous 3-D ICs (2017)

A heterogeneous contactless transceiver circuit is designed to provide half duplex communication for a 3-D system considering specific bonding constraints. The system is composed of two tiers and is integrated face-to-back to support fluidic sensing. Communication between the tiers is achieved through inductive links. Each tier is considered to be fabricated in a different technology node to enable low manufacturing cost and benefit from the advantages each technology offers. Both the uplink and downlink transceivers achieve data rates that reach 1 Gbps with non-return-to-zero data encoding. Energy efficiency is the primary objective, with the uplink dissipating 4.93 mW and the downlink 10.53 mW. A 5.2 × power reduction is achieved when using heterogeneous technologies, compared to a state-of-the-art 0.35 βm transceiver, while the dissipated energy is decreased by 34% as compared to a state-of-the-art 65 nm transceiver.
Spatio-temporal modelling-based drift-aware wireless sensor networks (2011)

Wireless sensor networks are deployed for the purpose of monitoring an area of interest. Even when the sensors are properly calibrated at the time of deployment, they develop drift in their readings leading to erroneous network inferences. Based on the assumption that neighbouring sensors have correlated measurements and that the instantiations of drifts in sensors are uncorrelated, the authors present a novel algorithm for detecting and correcting sensor measurement errors. The authors use statistical modelling rather than physical relations to model the spatio-temporal cross-correlations among sensors. This in principle makes the framework presented applicable to most sensing problems. Each sensor in the network trains a support vector regression algorithm on its neighbours&apos; corrected readings to obtain a predicted value for its future measurements. This phase is referred to here as the training phase. In the running phase, the predicted measurements are used by each node, in a recursive decentralised fashion, to self-assess its measurement and to detect and correct its drift and random error using an unscented Kalman filter. No assumptions regarding the linearity of drift or the density (closeness) of sensor deployment are made. The authors also demonstrate using real data obtained from the Intel Berkeley Research Laboratory that the proposed algorithm successfully suppresses drifts developed in sensors and thereby prolongs the effective lifetime of the network.
Expression of neuroblastoma‐related genes in bone marrow at end of high‐risk neuroblastoma therapy (2022)

If further validated in additional patient cohorts, the NB5 assay's ability to independently predict EFS from end-therapy could improve patient stratification for novel maintenance therapy trials after current end-therapy to improve outcome.
Demonstration of stable wavelength switching on a fast tunable laser transmitter (2003)

We describe a new technique to investigate continuous wavelength switching between 32 ITU channels in a tunable laser transmitter by switching the laser once every microsecond. We examine the effect of different switching schedules on the switching of the laser, an important issue for commercial switch fabrics for optical packet routing. Switching to all 32 channels of the laser is characterized in terms of a "packet-loss rate" (PLR) due to wavelength switching. PLRs are studied as a function of the switching-time window for a laser to tune to an ITU channel. Error-free wavelength switching in less than 50 ns is demonstrated for 26 hours.
A comparison of immunogenicity of norovirus GII‐4 virus‐like particles and P‐particles (2011)

Norovirus (NoV) -derived virus-like particles (VLPs) resemble empty shells of the virus and NoV P-particles contain only protruding domains of the NoV capsid. Both NoV-derived subviral particles show similar functionality and antigenicity in vitro and are considered to be potential vaccine candidates against NoV gastroenteritis. BALB/c mice were immunized with baculovirus-produced GII-4 VLPs or the corresponding Escherichia coli-produced P-particles by the intramuscular or intradermal route and the NoV-specific antibody and T-cell immune responses were compared. Elevated antibody levels were induced with a single VLP immunization, whereas P-particle immunization required a boost. High avidity antibodies were raised only by VLP immunization. VLP immunization resulted in a balanced T helper type 1/type 2 immune response whereas P-particles induced a T helper type 2-biased response. Only VLP immunization primed T cells for interferon-γ production. Most importantly, cross-reactive B and T cells were induced solely by VLP immunization. In addition, VLP antiserum blocked the binding of heterotypic VLPs to human histo-blood group antigen receptor and saliva. The findings in this study are relevant for the development of NoV vaccines.
Generation and Maintenance of iPSCs From CD34+Cord Blood Cells on Artificial Cell Attachment Substrate (2014)

Generation and Maintenance of iPSCs From CD34+Cord Blood Cells on Artificial Cell Attachment Substrate
Verteporfin Therapy for Subfoveal Choroidal Neovascularization in Age-Related Macular Degeneration (2002)

Vision outcomes for verteporfin-treated patients with predominantly classic lesions at baseline remained relatively stable from month 24 to month 36, although only approximately one third of the verteporfin-treated patients originally enrolled with this lesion composition had a month 36 examination. From these results, the TAP Study Group identified no safety concerns to preclude repeating photodynamic therapy with verteporfin. Additional treatment was judged likely to reduce the risk of further vision loss. Caution appears warranted in the absence of comparison with an untreated group during the extension and since not all patients in the TAP Investigation participated in the TAP Extension.
Trinocular disparity estimation with adaptive support weight and disparity calibration (2008)

A new trinocular stereo matching algorithm is proposed. The collinear trinocular stereo, which is an almost occlusion-free system, is adopted, and the classical binocular stereo algorithm, adaptive support weight, is used for window selection. A novel camera selection technique is presented to utilize the information of different target images more efficiently. Moreover, a trinocular disparity calibration algorithm is introduced, so the initial disparity can be refined and a precise result can be produced. Some image sequences of real scenes are used to evaluate our algorithm. The result shows that the proposed method can extract an accurate disparity map. It is concise and efficient.
ChemInform Abstract: New Fluorinated Nucleoside Analogues with 2‐Butenolide Rings Prepared by Nucleophilic Vinylic Fluorine Displacement in 4,4‐Dialkyl‐2,3‐difluorobut‐2‐en‐4‐olides. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Complexity of FGFR signalling in metastatic urothelial cancer (2015)

The FGFR inhibitor AZD4547 exhibits antitumour activity in a metastatic urothelial cancer displaying FGFR1, FGFR3, FGF-ligand and FRS2 expression. This lends support to the further exploration of FGFR inhibitors in urothelial cancer. Further studies are required to determinate the most effective way to select those patients most likely to respond.
Hybrid Polymer/UiO-66(Zr) and Polymer/NaY Fiber Sorbents for Mercaptan Removal from Natural Gas (2016)

Zeolite NaY and metal organic frameworks MIL-53(Al) and UiO-66(Zr) are spun with cellulose acetate (CA) polymer to create hybrid porous composite fibers for the selective adsorption of sulfur odorant compounds from pipeline natural gas. Odorant removal is desirable to limit corrosion associated with sulfur oxide production, thereby increasing lifetime in gas turbines used for electricity generation. In line with these goals, the performance of the hybrid fibers is evaluated on the basis of sulfur sorption capacity and selectivity, as well as fiber stability and regenerability, compared to their polymer-free sorbent counterparts. The capacities of the powder sorbents are also measured using various desorption temperatures to evaluate the potential for lower temperature, energy, and cost-efficient system operation. Both NaY/CA and UiO-66(Zr)/CA hybrid fibers are prepared with high sorbent loadings, and both have high capacities and selectivities for t-butyl mercaptan (TBM) odorant sorption from a model natural gas (NG), while being stable to multiple regeneration cycles. The different advantages and disadvantages of both types of fibers relative are discussed, with both offering the potential advantages of low pressure drop, rapid heat and mass transfer, and low energy requirements over traditional sulfur removal technologies such as hydrodesulfurization (HDS) or adsorption in a pellet packed beds.
Comparative Analysis of DNA‐Binding Selectivity of Hairpin and Cyclic Pyrrole‐Imidazole Polyamides Based on Next‐Generation Sequencing (2016)

Many long pyrrole-imidazole polyamides (PIPs) have been synthesized in the search for higher specificity, with the aim of realizing the great potential of such compounds in biological and clinical areas. Among several types of PIPs, we designed and synthesized hairpin and cyclic PIPs targeting identical sequences. Bind-n-Seq analysis revealed that both bound to the intended sequences. However, adenines in the data analyzed by the previously reported Bind-n-Seq method appeared to be significantly higher in the motif ratio than thymines, even though the PIPs were not expected to distinguish A from T. We therefore examined the experimental protocol and analysis pipeline in detail and developed a new method based on Bind-n-Seq motif identification with a reference sequence (Bind-n-Seq-MR). High-throughput sequence analysis of the PIP-enriched DNA data by Bind-n-Seq-MR presented A and T comparably. Surface plasmon resonance assays were performed to validate the new method.
Supplementary Figure 1 from Human Melanoma Metastases Demonstrate Nonstochastic Site-Specific Antigen Heterogeneity That Correlates with T-cell Infiltration (2023)

&lt;p&gt;PDF file - 73K, MDA and MHC II expression demonstrates a site cluster-specific pattern. (A) The distribution of antigen expression for each anatomic site cluster. The p-values indicate the probability that no variability exists across the site clusters as determined by the Kruskal-Wallis test.&lt;/p&gt;
Fahrplankonstruktion (2011)

ZusammenfassungUnter dem Fahrplan wird allgemein die vorausschauende Festlegung des Fahrtverlaufs der Züge verstanden. Dazu gehören für jeden Zug mindestens die folgenden wesentlichen Angaben: Zugnummer Verkehrstage Laufweg Ankunfts-, Abfahr- und Durchfahrzeiten auf den Betriebsstellen zulässige Geschwindigkeit in den einzelnen Abschnitten des Laufwegs.
Modeling and Analysis of the Meshing Losses of Involute Spur Gears in High-Speed and High-Load Conditions (2012)

A first-principle based mathematical model is developed in this paper to analyze the meshing losses in involute spur gears operating in high-load and high-speed conditions. The model is fundamentally simple with a few clearly defined physical parameters. It is computationally robust and produces meaningful trends and relative magnitudes of the meshing losses with respect to the variations of key gear and lubricant parameters. The model is evaluated with precision experimental data. It is then used to study the effects of various gear and lubricant parameters on the meshing losses including gear module, pressure angle, tooth addendum height, thermal conductivity, and lubricant pressure-viscosity and temperature-viscosity coefficients. The results and analysis suggest that gear module, pressure angle, and lubricant pressure-viscosity and temperature-viscosity coefficients can significantly affect the meshing losses. They should be the design parameters of interest to further improve the energy efficiency in high-performance, multistage transmission systems. Although the model is developed and results obtained for spur gears, the authors believe that the trends and relative magnitudes of the meshing losses with respect to the variations of the gear and lubricant parameters are still meaningful for helical gears.