gebhart/patrepeval huggingface dataset:
Data from Expression and Regulatory Role of GAIP-Interacting Protein GIPC in Pancreatic Adenocarcinoma (2023)

&lt;div&gt;Abstract&lt;p&gt;Regulator of G-protein signaling–GAIP-interacting protein COOH terminus (GIPC) is involved in protein trafficking, endocytosis, and receptor clustering and is associated with insulin-like growth factor I receptor (IGF-IR), a receptor important for proliferation and anchorage-independent growth. Here, we described GIPC expression in different human pancreatic adenocarcinoma (PCA) cell lines and we examined the role of GIPC in the regulation of IGF-IR protein levels in PCA. Interestingly, inhibition of GIPC expression by RNA interference led to reduced IGF-IR protein levels and a subsequent decrease in proliferation of PCA cells. We also determined that the PDZ domain of GIPC is essential for the post-translational regulation and the binding of IGF-IR. The importance of GIPC in pancreatic cancer development and progression is supported by tissue microarray data of 300 pancreatic cancer specimens where GIPC is highly expressed in PCA. Taken together, our data suggest that GIPC is a central molecule for the stability of IGF-IR and could be a target for future therapy. (Cancer Res 2006; 66(21): 10264-8)&lt;/p&gt;&lt;/div&gt;
Emerging drugs in migraine treatment (2003)

Ergot alkaloids have been the mainstay of acute migraine therapy for most of the 20th century. They have been supplanted by sumatriptan-like drugs ('triptans'), which, while keeping some of the ergotś mechanisms of action, show improved safety profiles due to their increased receptor selectivity. However, triptans are still far from being perfect drugs: they can constrict human coronary arteries at therapeutic doses and, therefore, are contra-indicated in the presence of cardiovascular disease. Another problem with these agents is recurrence of moderate-to-severe pain within 24 h of initial headache relief. While mechanism-driven drug design has led to the development of various novel, albeit still imperfect, acute antimigraine medications, only a few new prophylactic agents have been made available to migraine clinicians. The efficacy of most, if not all of them has been discovered serendipitously. This is probably due to the fact that, while the pathophysiology of a migraine attack is now reasonably understood, the mechanisms leading to an attack are still mostly unknown. This update analyses the profile of some antimigraine drugs in clinical trials, their mode of action and their potential advantages or drawbacks over already available agents.
FURTHER STUDIES OF AMINOBENZACRIDINES1 (1948)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFURTHER STUDIES OF AMINOBENZACRIDINES1G. BRYANT BACHMAN and FRANK M. COWENCite this: J. Org. Chem. 1948, 13, 1, 89–96Publication Date (Print):January 1, 1948Publication History Published online1 May 2002Published inissue 1 January 1948https://pubs.acs.org/doi/10.1021/jo01159a011https://doi.org/10.1021/jo01159a011research-articleACS PublicationsRequest reuse permissionsArticle Views104Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Abstract 1848: Let-7 brings new insights into chronic myeloid leukemia therapy. (2013)

Abstract Human chronic myelogenous leukemia (CML) is a malignancy of pluripotent hematopoietic cells that is caused by the deregulated activity of the tyrosine kinase that is encoded by the chimeric bcr-abl oncogene. Given that CML cells are usually highly resistant to chemotherapy, novel and more efficacious strategies against this disease are urgently needed. MicroRNA (miRNA) is a set of newly discovered 20-22 nucleotides RNA molecules, and they broadly repress their cognate target genes at post-transcriptional/translational level. Up to date, there are approximately 2,000 human miRNA transcripts have been characterized, which are estimated to modulate more than 30% human genes and are widely involved in many essential biological processes including differentiation, proliferation, apoptosis, and also tumorigenesis. In this study, we studied let-7, a miRNA with tumor suppressive signature, for its therapeutic potential in CML. When treating CML K562 and KU812 cell by imatinib, let-7 can be significantly induced. Overexpression of let-7 can sensitize K562 and KU812 cells to imatinib, while knock-down of let-7 can increase the drug resistance of these cells. The mechanistic studies found that let-7 was able to promote apoptosis of CML cells, inhibit the tumor cell proliferation, and lead to a cell cycle arrest in the G0/G1 phase. These results demonstrate that let-7 is a potential target for treating CML by imatinib and/or other anti-cancer druges. The pro-apoptosis and anti-proliferation roles of let-7 in CML cells may provide novel insights into discovery and development novel drugs for conquering this malignant disease. Citation Format: Bin Yi, Xiaobo Li, Wenjun Du, Gary A. Piazza, Yaguang Xi. Let-7 brings new insights into chronic myeloid leukemia therapy. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1848. doi:10.1158/1538-7445.AM2013-1848 Note: This abstract was not presented at the AACR Annual Meeting 2013 because the presenter was unable to attend.
The Effect of Desipramine upon Melatonin and Cortisol Secretion in Depressed and Normal Subjects (1985)

Melatonin and cortisol values in plasma were measured hourly over 24 hours in six depressed patients and six normal volunteers before treatment and after one and three weeks of treatment with desipramine. The normal volunteers were further tested one week after withdrawal of desipramine. The mydriatic effects of tyramine and phenylephrine eye drops were also recorded in the normal volunteers. In neither group of subjects did desipramine treatment reduce melatonin secretion, suggesting that functionally significant down-regulation of beta andrenoceptors was not caused by this treatment. Melatonin secretion was significantly increased after three weeks of treatment in depressed patients. This increase was not found in normal subjects.
ChemInform Abstract: Thermal and Microwave Hydrolysis of Organotrifluoroborates Mediated by Alumina. (2010)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Control of resonance separation over a wide spectral range in multiwavelength resonant grating filters (2007)

The spectral separation of resonances within multiwavelength resonant grating filters is studied through the use of a grating layer with constant structural parameters in combination with single-layer, multimode waveguides and multilayer, multimode waveguides. The use of multilayer, multimode waveguides are shown to provide the ability to control resonance separations for multiwavelength filters from hundreds of nanometers to only a few nanometers.
Well pattern design and optimal deployment for coalbed methane development (2016)

Based on the coalbed methane development of III block in the eastern edge of the Ordos Basin, the well pattern was optimized and dynamically adjusted, according to a system engineering including three stages: well pattern pre-development design stage, well site optimization stage and dynamic tracking stage. The geological basis for well deployment of coalbed methane was proposed and the parameters of well pattern design were optimized during the well pattern pre-development design stage. The geological conditions have been explored from several aspects which include coal bed structure, buried depth, coal seam thickness, roof and floor lithology, gas content, permeability and hydrological condition. The favorable production well pattern was the rhombus pattern. The cluster well was chosen as the main well type and then horizontal well. For the local anisotropy coal seam, rhombus long diagonal was in the direction of face cleats and short diagonal was in the direction of butt cleats. The well spacing was 300−350 m in high permeability zones and 350−400 m in low permeability zones. It is necessary to consider those factors, such as surface, subsurface and drilling conditions, to optimize the well locations during the well site optimization stage and to follow the basic requirements of “surface following subsurface, engineering following geology”. After having observed the well interference and interlayer interference phenomenon during the dynamic tracking stage, twenty-four production wells have been relocated and the producing layers for thirty-six production wells have been changed. Then the well pattern design was more reasonable in this block. It is confirmed that the posterior well pattern design and development mode are more reasonable after the optimal deployment in the III block during this five years.
Improving minimum cost spanning trees by upgrading nodes (1998)

The authors study budget constrained network upgrading problems. The authors are given an undirected edge weighted graph (G = V, E) where node v {element_of} V can be upgraded at a cost of c(v). This upgrade reduces the weight of each edge incident on v. The goal is to find a minimum cost set of nodes to be upgraded so that the resulting network has a minimum spanning tree of weight no more than a given budget D. The results obtained in the paper include the following: (1) on the positive side, they provide a polynomial time approximation algorithm for the above upgrading problem when the difference between the maximum and minimum edge weights is bounded by a polynomial in n, the number of nodes in the graph, the solution produced by the algorithm satisfies the budget constrain, and the cost of the upgrading set produced by the algorithm is O (log n) times the minimum upgrading cost needed to obtain a spanning tree of weight at most D; (2) in contrast , they show that, unless NP {improper_subset} DTIME (n{sup O(log log n)}), there can be no polynomial time approximation algorithm for the problem that produces a solution with upgrading cost at most {alpha} < ln n times the optimal upgrading cost even if the budget can be violated by a factor f(n), for any polynomial time computable function f(n), this result continues to hold, with f(n) = n{sup k} being any polynomial, even when the difference between the maximum and minimum edge weights is bounded by a polynomial in n; and (3) finally, they show that using a simple binary search over the set of admissible values, the dual problem can be solved with an appropriate performance guarantee.
Relaxation of Thermal Stress Singularities in Bonded Viscoelastic Quarter Planes (1989)

Singular thermal stress fields in bonded viscoelastic quarter planes are studied with the use of the viscoelastic analogy. The order of the singularity is shown to depend on the material properties, indicating that it will vary with time in viscoelastic materials. This is studied in detail for Maxwell materials, and it is shown that the order of the singularity generally increases with time. This evolution of the singularity can, for certain combinations of material properties, lead to initial increases in the stress levels near the edge of the interface before relaxation occurs.
A tool for full area inband EUV transmission mapping of EUV pellicles (2018)

The scene is set for EUV lithography high volume production. EUV masks with pellicles and scanners with dynamic gas lock thin film windows are considered a corner stone for insertion. For making the thin films usable in EUV scanners, EUV actinic metrology with high precision and accuracy is required to qualify them. One of the key features is the uniformity of the transmission at 13.5 nm through the thin film membrane to be qualified over the entire area. The specification for the required tool is qualifying a full sized EUV pellicle with an average EUV transmission of around 90 % to a uniformity of &lt; 99.6 % – hence precision and accuracy of the process of below 0.1 % are demanded. Certainly, no particles should be added to the EUV pellicle by the qualification measurement. Within RI Research Instrument's support of EUVL infrastructure by developing actinic metrology solutions, we have built a dedicated tool for EUV pellicle transmission characterization using the effective inband EUV scheme. The actinic measurement of the full pellicle is accomplished in less than 40 minutes. Vacuum loading and unloading consumes another 35 minutes due to the need of extreme care for such fragile samples and to avoid contamination. First images of full sized pellicles show precision and accuracy of better 0.1 % for a qualification pixel resolution of 300x300 &mu;m<sup>2</sup>.
Activated charcoal and graphite for the micropropagation of Cattleya bicolor Lindl. and a orchid double-hybrid ‘BLC Pastoral Innocence’ (2012)

No previous studies have investigated the use of graphite instead of activated charcoal in orchids. In this work, different concentrations of activated charcoal or graphite were added to KC medium to darken the culture medium and stimulate the in vitro propagation of Cattleya bicolor and of a double hybrid orchid ('BLC Pastoral Innocence'). The seedlings were inoculated on growth regulator-free KC medium; the effects of activated charcoal (0.0, 1.5, 3.0, 4.5, 6.0, and 7.5 g L -1 ) and graphite (0.0, 1.5, 3.0, 4.5, 6.0, and 7.5 g L -1 ) concentrations were tested separately. Each flask contained fifteen seedlings, and the experiments had a randomised, two-way factorial design. The two tested variables were culture medium and illumination levels; eleven culture levels (different concentrations of graphite or activate charcoal) and two illumination levels (14-hr photoperiod or continuous illumination) were evaluated. Three replicates of each combination were utilised. After six months of culture, the average numbers of induced buds and roots per seedling were recorded for each concentration of activated charcoal or graphite. Whereas the largest number of buds in C. bicolor seedlings occurred on media containing 6.0 or 7.5 g L -1 graphite, the largest number of roots occurred on media containing 6.0 g L -1 activated charcoal. In the hybrid 'BLC Pastoral Innocence', the largest number of buds and roots was reported in medium with 4.5 g L -1 activated charcoal. When using graphite in place of activated charcoal, we obtained disparate the results in root formation that suggest that graphite is not a recommended substitute for activated charcoal.
Supplementary Tables 1-4 from Characterization of caspase-dependent and caspase-independent deaths in glioblastoma cells treated with inhibitors of the ubiquitin-proteasome system (2023)

Supplementary Tables 1-4 from Characterization of caspase-dependent and caspase-independent deaths in glioblastoma cells treated with inhibitors of the ubiquitin-proteasome system
Decomposition of the time reversal operator (DORT) for extended objects (2006)

The decomposition of the time reversal operator, known by the French acronym DORT, is widely used to detect, locate, and focus on scatterers in various domains such as underwater acoustics, medical ultrasound, or nondestructive evaluation. In the case of point scatterers, the theory is well understood: the number of nonzero eigenvalues is equal to the number of scatterers, and the eigenvectors correspond to the scatterers’ Green function. In the case of extended objects, however, the formalism is not as simple. We show that, in the Fresnel approximation, analytical solutions can be found, and that the solutions are functions called prolate spheroidal wavefunctions. These functions have been studied in optics and information theory as a basis of band-limited and time-limited signals. The theoretical solutions are compared to simulation results and previous experimental results Most importantly, we justify the intuition that for an extended object, the number of nonzero eigenvalues is proportional to the number of resolution cells in the object. The case of 3-D objects imaged by a 2-D array will also be described.
Additions and Corrections - Proton-Exchange Reactions of Acetone and Butanone. Resolution of Steps in Catalysis by Acetoacetate Decarboxylase. (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAdditions and Corrections - Proton-Exchange Reactions of Acetone and Butanone. Resolution of Steps in Catalysis by Acetoacetate Decarboxylase.George Hammons, F. Westheimer, Kurt Nakaoka, and Ronald Kluger Cite this: J. Am. Chem. Soc. 1975, 97, 14, 4152Publication Date (Print):July 1, 1975Publication History Published online4 February 2004Published inissue 1 July 1975https://pubs.acs.org/doi/10.1021/ja00847a610https://doi.org/10.1021/ja00847a610research-articleACS PublicationsRequest reuse permissionsArticle Views24Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Evaluation of anti‐hepadnavirus activity of Phyllanthus amarus and Phyllanthus maderaspatensis in duck hepatitis b virus carrier Pekin ducks (1993)

Extracts of the two traditional Indian herbs, Phyllanthus amarus (P. amarus) and Phyllanthus maderaspatensis (P. maderaspatensis), described by others as useful in the treatment of chronic hepatitis B virus infection were studied for antiviral properties on duck hepatitis B virus infection. One hundred and fourteen ducks infected posthatch with the duck hepatitis B virus (DHBV) were divided into groups at three months of age and treated intraperitoneally with the aqueous, butanol, and alcoholic extracts of these two plants at doses of 25, 50, or 200 mg/kg body weight. Saline-treated animals served as controls. In the ducks negative for DHBV in serum after treatment, we observed replicative intermediates in the liver. There was no definite antiviral property observed in the treated ducks.
Anisotropy in the deep-sky radio-source distribution (1986)

The 21-cm deep-sky radio-source distribution data acquired by Windhorst (1984) with the Westerbork synthesis radio telescope were analyzed. In some of the survey fields, significant departures from a Poisson distribution were found. The correlation analysis of the data provides evidence for an anisotropic radio source distribution and supports the existence of a distant (redshift z of about 0.54) supercluster of galaxies. 5 references.
1882: Diagnostic Accuracy of Prostate-Specific Antigen Testing in Unscreened Men: Results from the European Randomized Study of Prostate Cancer Screening in Göteborg, Sweden (2007)

You have accessJournal of UrologyModerated Poster 59, Wednesday, May 23, 2007, 1:00 - 3:00 pm1 Apr 20071882: Diagnostic Accuracy of Prostate-Specific Antigen Testing in Unscreened Men: Results from the European Randomized Study of Prostate Cancer Screening in Göteborg, Sweden Hans G. Lilja, Angel M. Serio, Andrew J. Vickers, Brett S. Carver, and Jonas Hugosson Hans G. LiljaHans G. Lilja More articles by this author , Angel M. SerioAngel M. Serio More articles by this author , Andrew J. VickersAndrew J. Vickers More articles by this author , Brett S. CarverBrett S. Carver More articles by this author , and Jonas HugossonJonas Hugosson More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)32055-XAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "1882: Diagnostic Accuracy of Prostate-Specific Antigen Testing in Unscreened Men: Results from the European Randomized Study of Prostate Cancer Screening in Göteborg, Sweden." The Journal of Urology, 177(4S), p. 625 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 177Issue 4SApril 2007Page: 625 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Hans G. Lilja More articles by this author Angel M. Serio More articles by this author Andrew J. Vickers More articles by this author Brett S. Carver More articles by this author Jonas Hugosson More articles by this author Expand All Advertisement PDF DownloadLoading ...
SU‐FF‐T‐22: A Model to Evaluate the Spatial and Dosimetric Resolutions of IMRT for Desired High‐Gradient Dose Distributions (2007)

Purpose: To create a 3D model to simulate IMRT treatment delivery. The model includes dose distribution resolution degradation from the MLC leaf width and dose deposition. The resulting deliverable distribution may be evaluated to determine conformity and the achievable spatial and dosimetric resolution. Method and Materials: Phantom image sets were created to represent head and neck anatomy with critical structures. Image sets contained 128 slices, each 128×128 pixels, with 1mm pixel size. Target volumes with radioresistant subvolumes of varying size and shape were added to the image sets. A nine‐field treatment technique was simulated. Slice‐by‐slice along the beam central axis, the image set was sampled in the direction perpendicular to leaf motion at each leaf width center. Each slice was convolved with a rect function representing MLC leaf width and convolved with a dose spread kernel appropriate for the depth along the central axis of the beam. The resulting 3D dose distributions for each field were summed to give the deliverable dose distribution for the nine‐field treatment. Results: The result of the model is a deliverable dose distribution in 3D. This deliverable dose distribution may be analyzed by comparison with the desired dose distribution. Information on the distribution's conformity may be attained by calculation of a distance‐to‐agreement map to provide information on spatial resolution, or by calculation of a map containing percent differences in dose to give insight into the dosimetric resolution. Dose intensity profiles may be extracted from the deliverable dose distribution as a means to determine achievable dosimetric gradients. Conclusion: This 3D model simulates the degradation of an ideal dose distribution due to the IMRT treatment delivery process. The resulting deliverable dose distribution may be used for evaluating the achievable spatial and dosimetric resolution for the current IMRT technique.