gebhart/patrepeval huggingface dataset:
Detrimental arterial inflammatory effect of microparticles circulating in preeclamptic women: ex vivo evaluation in human arteries (2015)

Elevated plasmatic levels of lympho-monocyte and platelet microparticles (MPs) have been reported in preeclampsia. Previous studies suggest that MPs could participate in preeclampsia vascular impairment. In this study, we investigated the ex vivo vascular effects of MPs from preeclamptic women on arteries from normotensive pregnant women. Omental arteries were collected from normal pregnant women undergoing cesarean section and incubated during 24 h with MPs from normal pregnant or preeclamptic women. Vascular contraction to serotonin and phenylephrine was studied on a wire myograph with or without pharmacological selective inhibitors of inducible nitric oxide synthase (iNOS) and/or cyclo-oxygenase-2 (COX-2). Expression of iNOS, COX-2, and NF-κB and production of superoxide anion and 8-isoprostane were also assessed by immunohistological or biochemical staining and/or Western blot or ELISA assay, respectively. Microparticles from preeclamptic women, but not those from normal pregnant women, induced hyporeactivity to vasocontracturant agonists in omental arteries. Selective inhibitor of iNOS partially restored this arterial contraction, suggesting that nitric oxide (NO) is involved in vascular contractility alteration. Conversely, COX-2 induced 8-isoprostane release, a vasoconstricting metabolite modulating the agonist-induced contraction. COX-2 selective inhibitor almost abolished the arterial contraction in the same vessels. Interestingly, the association of iNOS and COX-2 selective inhibitors restored the contraction to control levels. Moreover, iNOS, COX-2, and NF-κB expressions are upregulated and superoxide anion levels increased in vessels incubated with MPs from preeclamptic women. In conclusion, circulating MPs from preeclamptic women induce vascular inflammation and enhance oxidative stress. These results suggest a possible role of MPs during preeclampsia-induced arterial dysfunction.
900-L liquid xenon cryogenic system operation for the MEG experiment (2009)

A cryogenic system for the MEG (muon rare decay) experiment has started operation at the Paul Sherrer Institute in Zurich. The main part of the MEG detector is the 900-L liquid xenon calorimeter for gamma ray detection, equipped with 850 photo multipliers directly immersed in liquid xenon. A 200 W pulse tube cryocooler enabled LN2-free operation of this calorimeter. A liquid purification system; using a liquid pump and a zero boil-off 1000-L cryogenic buffer dewar is also included in the system. The first entire engineering run was carried out in November-December 2007 and satisfactory cryogenic performances were confirmed.
All-optical switching using microring resonators including Quantum-Dots (2010)

In this article a Quantum Dots based method is proposed to enhance the nonlinear switching properties of a bulk GaAs/AlGaAs microring resonator. Switching is accomplished in the pump and probe configuration. Refractive index changes in the microring due to free carriers generated by two photon absorption are used to switch the probe beam in and out of resonance. It has been concluded that quantum dot doping would lead to higher nonlinearity and faster evolution in refractive index variation. A control pulse is applied to the structure to control the carrier lifetime and therefore manage the switching time.
Search for sub-eV axion-like particles in a stimulated resonant photon-photon collider with two laser beams based on a novel method to discriminate pressure-independent components (2022)

Sub-eV axion-like particles (ALPs) have been searched for by focusing two-color near-infrared pulse lasers into a vacuum along a common optical axis. Within the focused quasi-parallel collision system created by combining a creation field ($2.5\,\mathrm{mJ}/47\,\mathrm{fs}$ Ti:Sapphire laser) and a background inducing field ($1.5\,\mathrm{mJ}/9\,\mathrm{ns}$ Nd:YAG laser), the detection of signal photons via stimulated resonant photon-photon scattering by exchanging ALPs was attempted in a vacuum chamber. The signal wavelength can be determined via energy-momentum conservation in the vacuum, and it coincides with that determined from the atomic four-wave-mixing (aFWM) process. In this work, the pulse energies were one order of magnitude higher than those in the previous search, allowing aFWM from optical elements to be observed as a pressure-independent background for the first time, in addition to the residual-gas-originating aFWM following a quadratic pressure dependence. In principle the four-wave-mixing process in vacuum via ALP exchanges (vFWM) must also be pressure-independent, so the development of a new method for discriminating the optical-element aFWM is indispensable for increasing the pulse energies to the values needed for future upgraded searches. In this paper, we will present the established method for quantifying the yield from the optical-element aFWM process based on the beam cross-section dependence. With the new method, the number of signal photons was found to be consistent with zero. We then successfully obtained a new exclusion region in the relation between ALP-photon coupling, $g/M$, and the ALP mass $m$, reaching the most sensitive point $g/M = 1.14\times10^{-5}\,\mathrm{GeV^{-1}}$ at $m = 0.18\,\mathrm{eV}$.
Specific Etiologies Associated With the Multiple Organ Dysfunction Syndrome in Children: Part 2 (2020)

To describe a number of conditions and therapies associated with multiple organ dysfunction syndrome (MODS) presented as part of the Eunice Kennedy Shriver National Institute of Child Health and Human Development MODS Workshop (March 26–27, 2015). In addition, the relationship between burn injuries and MODS is also included although it was not discussed at the Workshop.
Pathogenesis of infection with a virulent allotropic variant of minute virus of mice and regulation by host genotype. (1991)

Neonates of various inbred strains of mice expressed three susceptibility phenotypes in response to infection with the lymphocyte-specific variant of minute virus of mice (MVMi). MVMi caused asymptomatic infections in C57BL/6 (B6) mice, lethal infections with intestinal hemorrhage in DBA/2 mice, and lethal infections with renal papillary hemorrhage in BALB/c, SWR, SJL, CBA, and C3H (H) mice. Sequential virus titration, histology, in situ hybridization with a full-length MVMi genomic probe, and immunohistochemistry for viral capsid antigen were used to compare the pathogenesis of MVMi infection in B6 and H mice. Peak infectious virus titers in heart, lung, liver, spleen, kidney and intestine did not differ between strains but brains of B6 mice, unlike H mice, were refractory to infection. Lesions in H mice consisted of renal papillary infarcts and accelerated involution of hepatic erythropoietic foci. No lesions were seen in B6 mice. In situ hybridization and immunohistochemistry indicated that three cell types were primary targets of MVMi; endothelium, lymphocytes, and hepatic erythropoietic precursors. Renal papillary infarcts in H mice were associated with virus replication in endothelial nuclei of the vasa recta. In contrast to the parity of infectious virus titers between strains, fewer cells in target organs of B6 mice were labeled with the MVMi probe then were labeled in H mice and fewer cells expressed viral capsid antigen. These results indicate (a) that the allotropic variants of minute virus of mice may be useful tools to dissect molecular mechanisms of parvovirus virulence, (b) that the virulence of MVMi for neonatal mice does not reside in its lymphotropism, and (c) that genetic susceptibility to lethal MVMi infection may result from overproduction of noninfectious virus products.
Session 2: Antimicrobial Susceptibility Testing (2018)

KN Direct phenotypic antimicrobial susceptibility testing under 30 minutes : Dynamics of single cell response revealed in automated microscopy with microfluidics
Near-Realistic Motion Video Games with Enforced Activity (2012)

Human activity monitoring, through the use of body-wearable sensors, allows for many exciting possibilities, from gaming, to exercise, to preventative health care, where childhood obesity is a growing epidemic. The rapidly increasing nature of this trend requires serious thought at targeting its causes and finding solutions. One major influence is video gaming and the hours of sedentary behavior associated with it. In this paper, we present our system for enforcing physical activity of humans playing video games with our body-worn sensor system as the controller. Body movements are communicated with the host computer that calculates physical activity via the metabolic equivalent of task, and runs signal processing algorithms to classify and enforce movements. A user study was conducted to validate the effectiveness and realism of the system while playing an actual video game and data was collected from these same users in order to verify the accuracy of our system. The results show a system that not only allows physical activity, but also enforces it, leading to healthier gaming and accurate motion analysis.
Managing layout constraints in a platform for customized multimedia content packaging (2002)

A promising approach to customize the delivery of multimedia content is based on methods for compiling content packages from repositories of existing media assets, such as text paragraphs and images. Since the authors of media assets may have specified layout preferences for their assets neither knowing in which package these assets eventually will occur, nor knowing the personal layout preferences of all potential customers, layout conflicts, such as incompatible style attributes, are preprogrammed when packages are compiled on the fly by an automated system. In this contribution we present a constraint-based approach for resolving layout conflicts in automatically compiled content packages. Depending on the number and nature of the layout constraints to be considered, many eligible layout styles may exist. In fact, the exploration of a style solution space creates a problem on its own. Therefore, we are also investigating clustering and visualization techniques to assist a system administrator in the exploration of the solution space. The work has been conducted in the context of the EU funded project IMAGEN which aims at the development of an integrated set of tools for the customized publication and distribution of multimedia content.
p55 IL-2 receptor mRNA precursors in murine T lymphocyte nuclei. (1988)

An unusual family of cDNA clones homologous to human p55 IL-2R sequences was isolated from the murine HT-2 Th cell line. These clones were mapped, partially sequenced, and compared with previously published human and mouse IL-2R sequences. They appear to consist of various combinations of exons and introns, suggesting that they are derived from p55 IL-2R mRNA precursors. The configuration of exons in the splicing intermediates indicates that the murine and human gene organizations are similar and that the 3' end of intron 3 is well conserved between the two species. RNA mapping experiments using nuclear, cytoplasmic, and total RNA and probes derived from various parts of the p55 IL-2R gene support and extend the sequence data. They indicate that detectable amounts of immature p55 IL-2R mRNA are found specifically in the cell nucleus of the HT-2 cell line. Similar data were obtained for the Th cell clone 52.3 and the cytotoxic T cell line CTLL. All these results indicate that the T cell nucleus contains significant amounts of immature p55 IL-2R mRNA.
AUTOMATED POLYP DIFFERENTIATION ON COLOSCOPIC DATA USING SEMANTIC SEGMENTATION WITH CNNS (2019)

Interval carcinomas are a commonly known problem in endoscopic adenoma detection, especially when they follow negative index colonoscopy. To prevent patients from these carcinomas and support the endoscopist, we reach for a live assisted system in the future, which helps to remark polyps and increase adenoma detection rate. We present our first results of polyp recognition using a machine learning approach.
Three-dimensional wafer stacking via Cu-Cu bonding integrated with 65-nm strained-Si/low-k CMOS technology (2006)

The authors report the first demonstration of integrating wafer stacking via Cu bonding with strained-Si/low-k 65-nm CMOS technology. Sets of 330 mm wafers with active devices such as 65-nm MOSFETs and 4-MB SRAMs were bonded face-to-face using copper pads with size ranging between 5 μm×5 μm and 6 μm×40 μm. The top wafers were thinned to different thicknesses in the range 5 to 28 μm. Through-silicon-vias (TSVs) and backside metallization were used to enable electrical testing of both wafers in the Cu-stacked configuration. We tested individual transistors in the thinned silicon of bonded wafer pairs where the thinned silicon thickness ranged from 14 to 19 μm. All results showed that both n- and p-channel transistors preserved their electrical characteristics after Cu bonding, thinning, and TSV integration. We also demonstrated the functionality of stacked 65-nm 4-MB SRAMs by independently testing the cells in both the thinned wafer and the bottom wafer. For the SRAM, we tested a wider thinned wafer thickness range from 5 to 28 μm. On all tested samples, we did not find any impact to the electrical performance of the arrays resulting from the three-dimensional (3-D) integration process. The stacked SRAM is an experimental demonstration of the use of 3-D integration to effectively double transistor packing density for the same planar footprint. The results presented in this letter enable further exploratory work in high-performance 3-D logic, which takes advantage of the improved interconnect delays offered by this Cu-bonding stacking scheme integrated with modern CMOS processes.
Follicular lymphoma grade 3B: is it a real disease? (2011)

Follicular lymphoma (FL) is defined as a neoplasm of germinal center B cells, usually with a follicular growth pattern. The neoplastic population typically consists predominantly of centrocytes, the resting cells present in the light zone of normal germinal centers, and relatively few centroblasts,
Mapping spectroscopic ellipsometry of CdTe solar cells for property-performance correlations (2014)

Mapping spectroscopic ellipsometry (M-SE) has been applied for optimization of polycrystalline CdS/CdTe solar cell fabrication on transparent conducting oxide (TCO) coated glass superstrates. During fabrication of these solar cells, the structure undergoes key processing steps after the sputter-deposition of the CdS/CdTe. These steps include CdCl <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> treatment of the CdTe layer and subsequent deposition of ultrathin Cu. Additional steps involve final metal back contact layer deposition and an anneal for Cu diffusion that completes the device. In this study, we have fabricated cells with variable absorber thickness, ranging from 0.5 to 2.5 μm, and variable CdCl2 treatment time, ranging from 5 to 30 min. Because both CdS window and Cu back contact layers are critical for determining device performance, an understanding of their deposition processes and process-property-performance relationships is important for device optimization. We have applied M-SE to map the effective thickness (volume/area) of the CdS and Cu films over 15 cm × 15 cm substrates prior to the fabrication of 16 × 16 arrays of dot cells. The model for M-SE analysis has been established using single-spot real time SE (RT-SE). We report correlations of cell performance parameters with the CdCl <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> treatment time and with the effective thicknesses from M-SE analysis. We demonstrate that correlations between optical/structural parameters extracted from M-SE analysis and device performance parameters facilitate process optimization.
Structural and Compositional Analysis of Vinylidene Fluoride-Hexafluoropropylene Copolymers by Nuclear Magnetic Resonance Spectroscopy (1960)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructural and Compositional Analysis of Vinylidene Fluoride-Hexafluoropropylene Copolymers by Nuclear Magnetic Resonance SpectroscopyRaymond C. FergusonCite this: J. Am. Chem. Soc. 1960, 82, 10, 2416–2418Publication Date (Print):May 1, 1960Publication History Published online1 May 2002Published inissue 1 May 1960https://pubs.acs.org/doi/10.1021/ja01495a003https://doi.org/10.1021/ja01495a003research-articleACS PublicationsRequest reuse permissionsArticle Views162Altmetric-Citations62LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Improving the quality of tiger shrimp Penaeus monodon through dietary incorporation of algae as a source of natural pigment (2015)

Tiger shrimp is one of the major candidate species for export oriented aquaculture which dominates the seafood market in regions of European Union, Japan and USA. Carotenoid content in seafood has now become one of the important criteria in determining the quality of edible product. Recent trends in supplementing fish diets with natural pigment source are an alternative to the utilization of expensive synthetic pigments. In this context, green algae Enteromorpha intestinalis was selected as a source of natural pigment for inclusion in the diet of tiger shrimp Penaeus monodon. Astaxanthin being an important category of carotenoid pigment was monitored in shrimp muscle tissue during the feeding trial. Significant variation (p&lt;0.05) was observed between the experimental groups as confirmed through ANOVA thus exhibiting higher astaxanthin content of shrimps (18.70 Å} 4.48 ppm) fed with E. intestinalis incorporated diet as compared to control (15.80 Å} 2.33 ppm). The present programme therefore emphasizes on the quality improvement of aquaculture product by dietary inclusion of algae as a natural pigment source.
High‐Q asymmetrically cladded silicon nitride 1D photonic crystals cavities and hybrid external cavity lasers for sensing in air and liquids (2022)

Abstract In this paper we show a novel design of high Q‐factor silicon nitride (SiN) 1D photonic crystal (PhC) cavities side‐coupled to curved waveguides, operating with both silica and air cladding. The engineering of the etched 1D PhC cavity sidewalls angle allows for high Q‐factors over a wide range of upper cladding compositions, and the achievement of the highest calculated Q‐factor for non‐suspended asymmetric SiN PhC structures. We show the employment of these type of SiN PhC cavities in hybrid external cavity laser (HECL) configuration, with mode‐hop free single mode laser operation over a broad range of injected currents (from 25 mA to 65 mA), milliwatts of power output (up to 9 mW) and side‐mode suppression ratios in the range of 40 dB. We demonstrate the operation of these devices as compact and energy efficient optical sensors that respond to refractive index changes in the surrounding medium the measurement of sodium chloride (from 0% to 25%) and sucrose (from 0% to 25%) in aqueous solution. In HECL configuration, the RI sensor exhibits a 2 orders of magnitude improvement in detection limit compared to the passive microcavity. We also discuss the possibility for applying these devices as novel transducers for refractive index changes that are induced by analyte specific absorption of infrared radiation by the target analytes present in gas or liquid phase.
Silicon CMOS compatible transition metal dioxide technology for boosting highly integrated photonic devices with disruptive performance (2014)

In this work we will present the objectives and last results of the FP7-ICT-2013-11-619456 SITOGA project. The SITOGA project will address the integration of transition metal dioxides (TMO) materials in silicon photonics and CMOS electronics. TMOs have unique electro-optical properties that will offer unprecedented and novel capabilities to the silicon platform. SITOGA will focus on two disruptive TMO materials, barium titanate (BaTiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> ) and vanadium didioxide (VO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ), for developing advanced photonic integrated devices for a wide range of applications. Innovative integration processes with silicon photonics circuits and CMOS electronics will be developed. The whole technology chain will be validated by two functional demonstrators: a 40 Gbit/s DPSK transceiver and an 8×8 switching matrix with 100 Gbit/s throughput.
A facile and highly stereoselective synthesis of trichonine by two consecutive reactions of arsonium salts (1988)

Abstract Trichonine ( 5 ) has been synthesized from 1‐hexadecanal ( 1 ) by two steps of consecutive olefination, in which formylmethyltriphenylarsonium bromide ( 2 ) and (pyrrolidinecarbonyl)methyltriphenylarsonium bromide ( 4 ) were used in the presence of potassium carbonate. The product was obtained in pure (2 E ,4 E ) configuration, and the overall yield reached 87%.
Effect of a Soluble Cocoa Fiber-Enriched Diet in Zucker Fatty Rats (2010)

The effects of a soluble cocoa fiber (SCF) were studied in Zucker fatty rats. Two groups of Zucker fatty rats were fed the following diets: standard diet and 5% SCF-enriched diet. A group of Zucker lean rats fed the standard diet was used for results comparison with obese Zucker animals. Solid and liquid intakes, body weight, plasma glucose, lipid profile, and systolic (SBP) and diastolic (DBP) blood pressure were recorded weekly. At the end of the experimental period insulin was determined, and fat apparent digestibility (FAD) and insulin resistance were calculated. The Zucker fatty rats fed 5% SCF-enriched diet showed less weight gain and food intake than those fed the standard diet. The group fed the fiber-enriched diet showed lower values of the total cholesterol/high-density lipoprotein cholesterol ratio and triglyceride levels than the standard group. FAD was also lower in the fiber group. Both SBP and DBP were decreased. In addition, SCF reduced plasma glucose and insulin, and as a consequence the insulin resistance was also decreased. Our data demonstrate that SCF resulted in an improvement of the studied risk factors associated with cardiometabolic disorders.