gebhart/patrepeval huggingface dataset:
Effects of Prenatal Ethanol Exposure on Phospholipase C-beta1 and Phospholipase A2 in Hippocampus and Medial Frontal Cortex of Adult Rat Offspring (1997)

Previous studies in our laboratory using a rat model of fetal alcohol exposure (FAE) suggest that FAE-induced behavioral deficits are, in part, linked to neurochemical and electrophysiological deficits in long-term potentiation (LTP) in the entorhinal cortical perforant path projection to the hippocampal formation. Several findings suggest that signal-activated phospholipase C (PLC) and phospholipase A2 (PLA2) are critical to the induction and maintenance of LTP. Thus, alterations in phospholipid metabolism may play a significant role in the LTP deficits observed in FAE offspring. To test this hypothesis, we measured PLC-β1 and PLA2 activities in the hippocampus and medial frontal cortex of adult rats prenatally exposed to ethanol. PLC-β1 activities were significantly decreased by 20 to 30% in both the hippocampus and medial frontal cortex of FAE rats, compared with ad libitum and pair-fed controls. Total Ca2+-dependent PLA2 activity was 25% lower in the medial frontal cortex of FAE rats, but did not significantly differ from controls in the hippocampal formation. Approximately 30% of the measured activity in both the medial frontal cortex and hippocampal formation of ad libitum and pair-fed animals was associated with an 85 kDa cytosolic PLA2 form. Cytosolic PLA2 activities were significantly reduced in both the medial frontal cortex and hippocampal formation of FAE rats, compared with controls. These changes in Ca2+-dependent PLA2 and PLC-β1 activities, coupled with reports of FAE-induced deficits in protein kinase C activity, indicate that prenatal exposure to moderate quantities of ethanol causes profound and long-lasting deficits in the cellular signaling mechanisms associated with activity-dependent synaptic plasticity and memory formation.
A dexterous system for laryngeal surgery (2004)

This work presents a design overview of a novel high DoF (degrees-of-freedom) system being developed for minimally invasive surgery of the throat. The system is designed to allow remote operation of 2-3 tools with high tip dexterity to enable suturing and soft-tissue manipulation while using the patient's mouth as the only entry port. The slave is a 34 DoF unit equipped with three snake-like distal dexterity units for surgical tool manipulation. Each of these units is a multi-backbone snakelike mechanism equipped with a detachable milli parallel manipulator allowing interchangeable tools to be used. The paper presents the outline of the kinematic analysis of the snake-like units and proposes one possible actuation redundancy resolution to allow further downsize scalability while reducing the risk of buckling of the primary backbone of the snake-like units. Finally, The work presents a first early experiment with a prototype of the snake-like unit.
Where Did My Variable Go? Poking Holes in Incomplete Debug Information (2023)

The availability of debug information for optimized executables can largely ease crucial tasks such as crash analysis. Source-level debuggers use this information to display program state in terms of source code, allowing users to reason on it even when optimizations alter program structure extensively. A few recent endeavors have proposed effective methodologies for identifying incorrect instances of debug information, which can mislead users by presenting them with an inconsistent program state.
Tissue Distribution, Metabolism, Anticonvulsant Efficacy, and Effect on Brain Amino Acid Levels of the Glia‐Selective γ‐Aminobutyric Acid Transport Inhibitor 4,5,6,7‐Tetrahydroisoxazolo[4,5‐c]pyridin‐3‐ol in Mice and Chicks (1986)

Using tritium-labelled 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol (THPO) its tissue distribution and metabolism were investigated in adult mice and 4-day-old chicks after systemic administration of the drug. It was found not to be significantly metabolized in the brain since metabolites of THPO corresponding to only approximately 8% of the parent compound could be detected 30 min after administration of the drug intramuscularly in mice. In the liver, however, THPO was found to be metabolized to a considerable extent. In chicks THPO metabolites were found in the brain but they accounted for less than 35% of the radioactivity. The brain concentration of THPO in mice and chicks corresponded to respectively 10 and 50% of the dose injected intramuscularly and the tissue level was essentially constant for at least 3 h after injection. Following systemic administration of THPO to mice and chicks the contents of aspartate, glutamate, glutamine, and gamma-aminobutyric acid (GABA) in whole brain and in synaptosomes was determined. It was found that only GABA contents were affected being increased in synaptosomes from mice and decreased in whole brain in chicks. Doses of THPO, which in chicks but not in mice led to brain levels that were sufficient to inhibit glial GABA uptake, were found to protect chicks but not mice against isonicotinic acid hydrazide-induced seizures. The findings are compatible with the notion that THPO exerts its anticonvulsant activity by inhibition of astrocytic GABA uptake.
High internal quantum efficiency in AlGaN multiple quantum wells grown on bulk AlN substrates (2015)

The internal quantum efficiency (IQE) of Al0.55Ga0.45N/AlN and Al0.55Ga0.45N/Al0.85Ga0.15N UVC MQW structures was analyzed. The use of bulk AlN substrates enabled us to undoubtedly distinguish the effect of growth conditions, such as V/III ratio, on the optical quality of AlGaN based MQWs from the influence of dislocations. At a high V/III ratio, a record high IQE of ∼80% at a carrier density of 1018 cm−3 was achieved at ∼258 nm. The high IQE was correlated with the decrease of the non-radiative coefficient A and a reduction of midgap defect luminescence, all suggesting that, in addition to dislocations, point defects are another major factor that strongly influences optical quality of AlGaN MQW structures.
Signal restoration algorithm for photoacoustic imaging systems (2022)

In a photoacoustic (PA) imaging system, the detectors are bandwidth-limited. Therefore, they capture PA signals with some unwanted ripples. This limitation degrades the resolution/contrast and induces sidelobes and artifacts in the reconstructed images along the axial direction. To compensate for the limited bandwidth effect, we present a PA signal restoration algorithm, where a mask is designed to extract the signals at the absorber positions and remove the unwanted ripples. This restoration improves the axial resolution and contrast in the reconstructed image. The restored PA signals can be considered as the input of the conventional reconstruction algorithms (e.g., Delay-and-sum (DAS) and Delay-multiply-and-sum (DMAS)). To compare the performance of the proposed method, DAS and DMAS reconstruction algorithms were performed with both the initial and restored PA signals on numerical and experimental studies (numerical targets, tungsten wires, and human forearm). The results show that, compared with the initial PA signals, the restored PA signals can improve the axial resolution and contrast by 45% and 16.1 dB, respectively, and suppress background artifacts by 80%.
Inhibition of ATP-regulated K+ channels precedes depolarization-induced increase in cytoplasmic free Ca2+ concentration in pancreatic beta-cells. (1987)

The effects of glucose, diazoxide, K+, and tolbutamide on the activity of K+ channels, membrane potential, and cytoplasmic free Ca2+ concentration were investigated in beta-cells from the Uppsala colony of obese hyperglycemic mice. With [K+]e = [K+]i = 146 mM, it was demonstrated that the dominating channel at the resting potential is a K+ channel with a single-channel conductance of about 65 picosiemens and a reversal potential of about +70 mV (pipette potential). This channel is characterized by complex kinetics with openings grouped in bursts. The channel was completely inhibited by 20 mM glucose in intact cells or by intracellularly applied Mg-ATP (1 mM). The number of active channels was markedly reduced already by 5 mM glucose. However, the single channel current of the channels remaining active was unaffected, indicating no major depolarization. To evoke a substantial depolarization of the membrane and thereby action potentials, a total block in channel activity was necessary. This could be achieved either by increasing the concentration of glucose to 20 mM or by combining 5 mM glucose with 100 microM tolbutamide. In both cases, the effect was counteracted by the hyperglycemic sulfonamide diazoxide. The effects on single channel activity were paralleled by changes in membrane potential and cytoplasmic free Ca2+ concentration, also when the latter measurements were performed at room temperature. The transient increase in the number of active channels and the resulting hyperpolarization observed after raising the glucose concentration to 20 mM probably reflected a drop in cytoplasmic ATP concentration. It is suggested that ATP works as a key regulator of the beta-cell membrane potential and thereby the opening of voltage-activated Ca2+ channels.
Comparative study between deep learning and QSAR classifications for TNBC inhibitors and novel GPCR agonist discovery (2020)

Machine learning is a well-known approach for virtual screening. Recently, deep learning, a machine learning algorithm in artificial neural networks, has been applied to the advancement of precision medicine and drug discovery. In this study, we performed comparative studies between deep neural networks (DNN) and other ligand-based virtual screening (LBVS) methods to demonstrate that DNN and random forest (RF) were superior in hit prediction efficiency. By using DNN, several triple-negative breast cancer (TNBC) inhibitors were identified as potent hits from a screening of an in-house database of 165,000 compounds. In broadening the application of this method, we harnessed the predictive properties of trained model in the discovery of G protein-coupled receptor (GPCR) agonist, by which computational structure-based design of molecules could be greatly hindered by lack of structural information. Notably, a potent (~ 500 nM) mu-opioid receptor (MOR) agonist was identified as a hit from a small-size training set of 63 compounds. Our results show that DNN could be an efficient module in hit prediction and provide experimental evidence that machine learning could identify potent hits in silico from a limited training set.
Bioavailability in healthy adults of efavirenz capsule contents mixed with a small amount of food (2010)

The AUC of efavirenz 600 mg administered as capsule sprinkles with two teaspoons of applesauce, grape jelly, yogurt, or infant formula was bioequivalent to a single dose of efavirenz 600 mg given as intact capsules under fasting conditions in healthy adults.
MOTHERS AND SONS (2010)

In the rural immigrant community of Istanbul, poor women spend up to fifty hours a week producing goods for export, yet deny that they actually 'work'. Money Makes Us Relatives asks why Turkish society devalues women's work, concealing its existence while creating a vast pool of cheap labor for the world market. Drawing on two years of ethnographic fieldwork among family producers and pieceworkers, and using fascinating case studies throughout, Jenny B. White shows how women's paid work is viewed in terms of kinship relations of reciprocity and obligation - an extension of domestic work for the family, which is culturally valued but poorly compensated. Whilst offering the benefits of social identity and long-term security, women's work also reflects global capitalism's ability to capture local cultural norms, and to use these to lower production costs and create exploitative conditions. This fully revised second edition includes a new introduction and conclusion, updated references, comparative material on women's labor elsewhere in the world, and brand new material on Islam, globalization, gender and Turkish family life. It is an important contribution to debates about women's participation in late global capitalism.
High antigen levels are the cause of T cell exhaustion during chronic viral infection (2009)

Many persistent viral infections induce dysfunctional T cell responses. Although a negative correlation exists between viral load and T cell responses during chronic infection, it is not known whether high antigen levels are the cause or just the consequence of T cell exhaustion. Furthermore, it is unclear what role antigen presentation by bone-marrow (BM) derived versus infected parenchymal cells has on T cell exhaustion. To address these issues, we examined the influence of antigen presentation by different cell types on CD8(+) T cell responses during persistent infection of mice with lymphocytic choriomeningitis virus (LCMV) clone 13. We generated BM chimeric mice, in which non-BM derived cells were MHC class I deficient. Virus-specific CD8(+) T cells in lymphoid and nonlymphoid tissues were increased in both number and ability to produce cytokines in these mice soon after infection. However, viral clearance from infected MHC I(-/-) parenchyma was significantly impaired, despite increased populations of cytokine producing CTL. The CD8(+) T cell response was overwhelmed by sustained antigen persistence, becoming increasingly exhausted within 4-6 weeks. Thus, we find that (i) sustained antigen presentation directly drives T cell exhaustion during a chronic viral infection, (ii) CTL require direct antigen-MHC interactions to clear virus-infected cells, and (iii) persistent interactions with antigen presented on both hematopoietic and nonhematopoietic cells negatively impacts virus-specific T cell responses during chronic infection.
A prospective series of unruptured ectopic pregnancies treated by tubal injection with hyperosmolar glucose (1995)

Laparoscopic injection with hyperosmolar glucose is an effective, systemically nontoxic alternative treatment for select unruptured ectopic pregnancies (hCG less than 2500 mIU/mL) that achieves tubal patency rates comparable to other conservative medical and surgical treatments.
Therapeutic interventions and adjustments in the management of Parkinson disease: role of combined carbidopa/levodopa/entacapone (Stalevo&reg;) (2010)

Parkinson disease (PD) is a neurodegenerative disorder characterized by 3 cardinal motor symptoms: resting tremor, rigidity, and bradykinesia. Since its introduction 40 years ago, levodopa has represented the gold standard for dopaminergic stimulation therapy in patients with PD. Levodopa is routinely combined with a dopa-decarboxylase inhibitor (DDCI) to prevent the conversion of levodopa into dopamine in peripheral circulation. However, up to 80% of patients treated with continuous levodopa manifest the onset of disabling motor complications capable of producing an adverse effect on quality of life as the disease progresses. In recent years, a new, safe, and efficacious armamentarium of treatment options has been provided by the marketing of the catechol-O-methyltransferase (COMT) inhibitor, entacapone, a peripheral blocker of dopa to 3-0-methyldopa metabolism, which increments levodopa brain availability. When administered with levodopa, entacapone conjugates the rapid onset of levodopa-induced effects with a protracted efficiency, thus providing additional benefits to classic levodopa treatment by increasing "on" time in fluctuating PD patients, and theoretically providing a more continuous and physiological-like stimulation of dopamine receptors implying a reduced risk of motor complications. In this context, the use of a single administration of combined carbidopa/ levodopa/entacapone (Stalevo(®)) in the treatment of PD affords clinical improvements similar to those obtained by 2 separate tablets (ie, levodopa/DDCI and entacapone), although the former produces a more positive effect on quality of life than the latter. Additionally, the STalevo Reduction In Dyskinesia Evaluation (STRIDE-PD) study was designed with the aim of demonstrating that the combination of levodopa, carbidopa, and entacapone, used as initial levodopa therapy, significantly delays the onset of dyskinesias compared with the conventional levodopa/carbidopa formulation. Unfortunately, STRIDEPD failed to prove the benefit of continuous dopaminergic stimulation with triple therapy in a clinical setting. Recently, the effect of combined COMT inhibitor with levodopa administration in reducing homocysteine synthesis has been described. To this regard, clear evidence has been presented indicating homocysteine as a risk factor for vascular diseases, cognitive impairment, and dementia. Several studies have discussed the potential of entacapone as adjunct to levodopa/ DDCI in reducing plasma homocysteine levels with contrasting results.
Perpendicular magnetization in CoO (111) layers induced by exchange interaction with ferromagnetic Co and Ni60Cu40 nanoclusters (2012)

The magnetization reversal of ferromagnetic nanoparticles coupled by exchange with a CoO (111) thin film has been studied. The interfacial exchange interaction triggers the appearance of an out-of-plane magnetization in the CoO (111) film. Co and Ni60Cu40 particles were chosen, as they present an order of magnitude difference in the saturation magnetization and Curie temperatures that surround the Néel temperature of CoO. In both cases, the exchange coupling leads to an increase of the coercive field, up to 200% in Co particles, and small exchange bias of 100 Oe when the external magnetic field is applied in the CoO (111) plane. When the field is applied along the CoO [111] direction, an unexpected net magnetization of the CoO (111) layer is revealed. Interestingly, it scales with the particles magnetization. The results are explained in terms of a large interfacial interaction and an induced canting of the CoO spins in the close region of the interface. The large value of the CoO magnetization indicates that the canting settles over an extended thickness of at least 3.7 nm and 1.2 nm in the cases of Co and Ni60Cu40 particles, respectively, which is consistent with a compensated antiferromagnetic spins surface.
Antibacterial effect of orange Monascus pigment against Staphylococcus aureus (2019)

The objective of this work was to research the antibacterial effects of orange pigment, which was separated from Monascus pigments, against Staphylococcus aureus. The increase of the diameter of inhibition zone treated with orange pigment indicated that orange pigment had remarkable antibacterial activities against S. aureus. Orange pigment (10 mg ml −1 ) had a strong destructive effect on the membrane and structure of S. aureus by the analysis of scanning electron microscopy as well as transmission electron microscopy. Sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) further demonstrated that the cell membrane was seriously damaged by orange pigment, which resulted in the leakage of protein from S. aureus cells. A significant decrease in the synthesis of DNA was also seen in S. aureus cells exposed to 10 mg ml −1 orange pigment. All in all, orange pigment showed excellent antibacterial effects against S. aureus .
Microstructure and Electrical Properties of Nonstoichiometric Strontium Titanate Thin Films Grown on Platinum Electrodes (2001)

Nonstoichiometric strontium titanate films with the Sr/Ti ratio ranging from 0.9 to 1.4 were grown on Pt electrodes fabricated on Si substrates (Pt/Ta/SiO 2 /Si) by the RF-sputtering method with low and high deposition temperatures (250°C and 600°C, respectively). The insulating and dielectric properties of nonstoichiometric SrTiO 3 films have been studied as a function of Sr/Ti ratio. The highest dielectric constant was obtained by a SrTiO 3 film with a slight excess of SrO independent of the deposition temperature; the film showed better insulating property in comparison with the stoichiometric specimen, while the insulating property of TiO 2 -excess SrTiO 3 films, consisting of SrTiO 3 crystalline phase and Ti excess amorphous phase, notably depended on the deposition temperature. The high-temperature deposition resulted in better insulative resistance.
Experimental and Theoretical Insights into the Hydrogen-Efficient Direct Hydrodeoxygenation Mechanism of Phenol over Ru/TiO2 (2015)

Catalytic reduction of pyrolyzed biomass is required to remove oxygen and produce transportation fuels, but limited knowledge of how hydrodeoxygenation (HDO) catalysts work stymies the rational design of more efficient and stable catalysts, which in turn limits deployment of biofuels. This work reports results from a novel study utilizing both isotopically labeled phenol (which models the most recalcitrant components of biofuels) with D2O and DFT calculations to provide insight into the mechanism of the highly efficient HDO catalyst, Ru/TiO2. The data point to the importance of interface sites between Ru nanoparticles and the TiO2 support and suggest that water acts as a cocatalyst favoring a direct deoxygenation pathway in which the phenolic OH is replaced directly with H to form benzene. Rather than its reducibility, we propose that the amphoteric nature of TiO2 facilitates H2 heterolysis to generate an active site water molecule that promotes the catalytic C–O bond scission of phenol. This work has clear implications for efforts to scale-up the hydrogen-efficient conversion of wood waste into transportation fuels and biochemicals.
Efficient Estimation of the Band-Ratio of HPEM Sources for IEME Classification (2022)

This letter presents an efficient method for the estimation of the band-ratio for discrete spectra. We propose an algorithm that performs an efficient search of the boundary frequencies used to calculate the band-ratio. Then, this algorithm is improved through an adaptive resampling algorithm that reduces the number of samples in the spectrum while maintaining the integrity of the frequency representation. The proposed approach is compared with two additional methods and tested on several types of pulses to validate its efficiency.
Modèle de croissance de fiabilité pour des systèmes réparables en essais de développement (2015)

International audience
Two-step method for preparation of Al2O3/IF-WS2 nanoparticles composite coating (2013)

Al2O3/IF-WS2 nanocomposite coating was prepared in a two-step process. The Al2O3 nano-fibers are the matrix of the composite and the nanoparticles of WS2 with fullerene-like structure (IF-WS2) are the dispersed phase material, which can improve the mechanical and tribological properties of the nanocomposite. Detailed structural analysis of the nanocomposites was performed using scanning electron microscopy (SEM) and X-ray diffraction. These analyses show that the IF nanoparticles are entrapped in the microporous surface-film of the alumina matrix. The structure and mechanical properties of the nanosized Al2O3/IF-WS2 nanocomposite film was analyzed. This analysis demonstrates that the hardness and composition of the film exhibits graded functional material characteristics, suggesting possible tribological applications.