gebhart/patrepeval huggingface dataset:
Waterborne nanocellulose coatings for improving the antifouling and antibacterial properties of polyethersulfone membranes (2020)

This article presents a waterborne nanocellulose coating process to change the surface characteristics and mitigate fouling of commercially available polyethersulfone (PES) microfiltration membranes. An extensive comparative study between nanoporous and nano-textured layers composed of cellulose nanocrystals (CNC) or TEMPO-oxidized cellulose nanofibrils (T-CNF), which were coated on the PES membrane by taking advantage of the electrostatic interactions between the PES substrate, a polyallylamine hydrochloride (PAHCl) anchoring layer, and the nanocellulose functional layer. Coated PES membranes exhibited decreased surface roughness and pore sizes as well as rejection of compounds with a Mw above 150 kDa, while the water permeability and mechanical properties of remained largely unaffected. The coatings improved the wettability as confirmed by a reduction of the contact angle by up to 52% and exhibited a higher negative surface charge compared to the uncoated membranes over a pH range of 4–8. A significant reduction in organic fouling was observed for the coated membranes demonstrated by bovine serum albumin (BSA) adsorption studies on T-CNF and CNC surfaces using Quartz Crystal Microbalance with Dissipation monitoring (QCM-D), UV–vis spectroscopy and FTIR mapping after exposing the membranes to dynamic adsorption of BSA. The T-CNF coating exhibited effective antibacterial action against Escherichia coli (E. coli) attributed to the pH reduction effect induced by the carboxyl groups; while CNC coatings did not show this property. This work demonstrates a simple, green, and easy-to-scale layer-by-layer coating process to tune the membrane rejection and to improve antifouling and antibacterial properties of commercially available membranes.
Effectiveness of exendin-4 on blood glucose level of Streptozotocin-induced diabetic mice (2004)

Objective To investigate the effectiveness of exendin-4 on glucose level of streptozotocin(STZ)-induced diabetic mice. Methods Male eight-week-old C57BL/6 mice were divided into six groups: aqua-injected group, exendin-4 0.1 μg/g weight group, STZ group, STZ+exendin-4 (0.1, 0.2, 0.4 μg/g weight) groups. The blood glucose levels were determined on the first 10 days during the treatment and on day 12, 15, 18, 24 after the treatment. All mice were subjected to an intraperitoneal glucose tolerance test (IPGTT) on day 30. Results There was no statistical difference between the groups of aqua-injected group and exendin-4 groups 0.1 μg/g weight group during and after the treatment. As compared with STZ treated group only, STZ+varying doses of exendin-4 groups showed a lower blood glucose level throughout the study (P 0.05); the 0.1 μg/g weight dose gave the best result, there was no significant difference as compared with the aqua-injected group in normal mice (P 0.05), and there was no notable difference among the three groups after the treatment. The results of IPGTT on 30th day showed no distinct difference either.Conclusion Exendin-4 would not lead to hypoglycemia in normal mice but can improve the hyperglycemia in STZ-induced diabetic mice, it also has a prolonged effect on blood glucose level independent of dose.
Quantitative assessment of proton beam dose and myocardial lesion formation detected by high-resolution, ex vivo delayed contrast-enhanced MRI for treatment of ventricular tachycardia (2021)

Proton beam therapy has the potential to non-invasively treat ventricular tachycardia (VT) by homogenizing infarct scar. It has been previously demonstrated that proton beam therapy can create lesions in healthy myocardial tissue, thereby suggesting a potential for treatment of VT. In prior work, we quantified the relationship between dose delivered to myocardial tissue with lesion formation identified with in vivo, delayed contrast-enhanced magnetic resonance imaging (DCE-MRI) scans. In the current work, we evaluate the relationship of delivered dose with lesions identified in high resolution, post-mortem DCE-MRI scans. Deformable registration is used to align the dose maps from the baseline planning CT scans to ex vivo scans following proton beam therapy in swine. The current study demonstrates that nearly 100% of tissue exposed to a dose of 30 Gy or higher developed into lesion and approximately 85% of the tissue in the 20-30 Gy interval developed into lesion. On the other hand, tissue exposed to doses of 10 Gy or less tended to remain healthy myocardium, with less than 10% of tissue in the 5-10 Gy range and almost no tissue in the 0-5 Gy range developing into lesion.
Understanding and Effectively Managing Asian Employees (1992)

Asian‐American is a quite diversified ethnic group. Each nationality maintain its own culture and identity while most still enjoy a similar central Asian culture. The Asian population is rapidly growing, especially on the West Coast of America where 17 percent (Patel, D.I. 1988) of the total population is composed of Asians. By the year 2000 only 15 percent (Hutchens, S. Jr. 1989) of the additional workers drawn to American corporations will be whites, i.e. most new workers will be from other ethnic groups including Asians. Asian employees present a particular group pattern of behaviour and attitude which results from their cultural backgrounds, e.g. lack of initiative, respect for authority and self‐restraint. They also experience problems in handling the English language and expressions. American management faces the challenge of understanding and effectively managing Asian employees. A competitive edge will be obtained by whoever best understands this new diverse labour force of which the Asian employees are a significant part.
Faceted exploration of image search results (2010)

This paper describes MediaFaces, a system that enables faceted exploration of media collections. The system processes semi-structured information sources to extract objects and facets, e.g. the relationships between two objects. Next, we rank the facets based on a statistical analysis of image search query logs, and the tagging behaviour of users annotating photos in Flickr. For a given object of interest, we can then retrieve the top-k most relevant facets and present them to the user. The system is currently deployed in production by Yahoo!'s image search engine1. We present the system architecture, its main components, and the application of the system as part of the image search experience.
Co-Regulation of NF-κB and Inflammasome-Mediated Inflammatory Responses by Myxoma Virus Pyrin Domain-Containing Protein M013 (2009)

NF-kappaB and inflammasomes both play central roles in orchestrating anti-pathogen responses by rapidly inducing a variety of early-response cytokines and chemokines following infection. Myxoma virus (MYXV), a pathogenic poxvirus of rabbits, encodes a member of the cellular pyrin domain (PYD) superfamily, called M013. The viral M013 protein was previously shown to bind host ASC-1 protein and inhibit the cellular inflammasome complex that regulates the activation and secretion of caspase 1-regulated cytokines such as IL-1beta and IL-18. Here, we report that human THP-1 monocytic cells infected with a MYXV construct deleted for the M013L gene (vMyxM013-KO), in stark contrast to the parental MYXV, rapidly induce high levels of secreted pro-inflammatory cytokines like TNF, IL-6, and MCP-1, all of which are regulated by NF-kappaB. The induction of these NF-kappaB regulated cytokines following infection with vMyxM013-KO was also confirmed in vivo using THP-1 derived xenografts in NOD-SCID mice. vMyxM013-KO virus infection specifically induced the rapid phosphorylation of IKK and degradation of IkappaBalpha, which was followed by nuclear translocation of NF-kappaB/p65. Even in the absence of virus infection, transiently expressed M013 protein alone inhibited cellular NF-kappaB-mediated reporter gene expression and nuclear translocation of NF-kappaB/p65. Using protein/protein interaction analysis, we show that M013 protein also binds directly with cellular NF-kappaB1, suggesting a direct physical and functional linkage between NF-kappaB1 and ASC-1. We further demonstrate that inhibition of the inflammasome with a caspase-1 inhibitor did not prevent the induction of NF-kappaB regulated cytokines following infection with vMyxM013-KO virus, but did block the activation of IL-1beta. Thus, the poxviral M013 inhibitor exerts a dual immuno-subversive role in the simultaneous co-regulation of both the cellular inflammasome complex and NF-kappaB-mediated pro-inflammatory responses.
Vortex Breakdown Over Unsteady Wings and Its Control. (1995)

Abstract : Control of vortex breakdown continues to be of vital importance because the breakdown may have a considerable effect on aircraft performance, such as the effect on the time-averaged lift force (Lee and Ho, 1990). Breakdown is also important because of the unsteady nature of flow downstream of vortex breakdown. The unsteadiness may affect the stability of the aircraft and also cause buffeting. The objectives of this work are to understand the physics of unsteady flow phenomena in vortex breakdown region, and to develop techniques for active (feedback) and passive (open loop) control of vortex breakdown over steady and unsteady delta wings.
Wilms Tumor With Aniridia/Iris Dysplasia and Apparently Normal Chromosomes (1982)

No AccessJournal of Urology1 Sep 1982Wilms Tumor With Aniridia/Iris Dysplasia and Apparently Normal Chromosomes V.M. Riccardi, H.M. Hittner, L.C. Strong, D.J. Fernbach, R. Lebo, and R.E. Ferrell V.M. RiccardiV.M. Riccardi More articles by this author , H.M. HittnerH.M. Hittner More articles by this author , L.C. StrongL.C. Strong More articles by this author , D.J. FernbachD.J. Fernbach More articles by this author , R. LeboR. Lebo More articles by this author , and R.E. FerrellR.E. Ferrell More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)53093-1AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Wilms Tumor With Aniridia/Iris Dysplasia and Apparently Normal Chromosomes." The Journal of Urology, 128(3), p. 656 © 1982 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 128Issue 3September 1982Page: 656 Advertisement Copyright & Permissions© 1982 by The American Urological Association Education and Research, Inc.MetricsAuthor Information V.M. Riccardi More articles by this author H.M. Hittner More articles by this author L.C. Strong More articles by this author D.J. Fernbach More articles by this author R. Lebo More articles by this author R.E. Ferrell More articles by this author Expand All Advertisement PDF downloadLoading ...
Photo-induced decarbonylation of β-styryl isocyanates (1972)

G. J. Mikol and J. H. Boyer, J. Chem. Soc., Chem. Commun., 1972, 439 DOI: 10.1039/C39720000439
The substance P receptor antagonist CP-99,994 reduces acute postoperative pain* (1998)

This replicate demonstration that a NK1 receptor blocker relieves clinical pain supports the hypothesis that substance P contributes to the generation of pain in humans. The reduction in postoperative pain at doses not producing side effects suggests that NK1 antagonists may be clinically useful.
Physical distribution planning with simulation (1972)

The problem considered in this paper is that of long range planning of physical distribution systems and how this may be improved through simulation
Learning Multi-Level Density Maps for Crowd Counting (2019)

People in crowd scenes often exhibit the characteristic of imbalanced distribution. On the one hand, people size varies largely due to the camera perspective. People far away from the camera look smaller and are likely to occlude each other, whereas people near to the camera look larger and are relatively sparse. On the other hand, the number of people also varies greatly in the same or different scenes. This article aims to develop a novel model that can accurately estimate the crowd count from a given scene with imbalanced people distribution. To this end, we have proposed an effective multi-level convolutional neural network (MLCNN) architecture that first adaptively learns multi-level density maps and then fuses them to predict the final output. Density map of each level focuses on dealing with people of certain sizes. As a result, the fusion of multi-level density maps is able to tackle the large variation in people size. In addition, we introduce a new loss function named balanced loss (BL) to impose relatively BL feedback during training, which helps further improve the performance of the proposed network. Furthermore, we introduce a new data set including 1111 images with a total of 49 061 head annotations. MLCNN is easy to train with only one end-to-end training stage. Experimental results demonstrate that our MLCNN achieves state-of-the-art performance. In particular, our MLCNN reaches a mean absolute error (MAE) of 242.4 on the UCF_CC_50 data set, which is 37.2 lower than the second-best result.
Textural Characteristics of Australian Foods (2020)

Australian cuisine reflects the dramatic changes in its society over the last 230 years, since the arrival of the First Fleet at Sydney in 1788. The basic mouthfeel desired by the Australian palate is due to the fat component of most of the elements making the final formulation. The flat white is considered as an Australian icon and this is prepared by pouring steamed milk over a shot of espresso. Australian cuisine accepts and increasingly enjoys the full range of cheeses from Europe, including goat and ewe. Texture terms must be further developed in the Australian culture. Texture profile analysis under compression testing is a valuable tool for assessing the textural characteristics of solid-like food products, including cereals. Texture is expected to range from a smooth oily sensation to a dry mouthfeel with some adhering to the roof of the mouth.
Predictive Control of a Diesel Engine Air Path (2007)

This brief addresses the model-based control of the air path of diesel engines in terms of an optimal control problem with input constraints which can be solved using model predictive algorithms. A multilinear model identified from data and a switched controller design are used to cope with the nonlinearity of the engine. Experimental results on a production engine confirm that the proposed control method strongly improves the dynamics of the air path and enormously reduces the parameterization work if compared with the conventional approach. To obtain improvements in emissions as well, the new controller approach cannot simply be plugged in at the site of the conventional one, but new set points must be determined. After such a redesign, improvements of 50% in terms of nitrogen oxides and of 10% in terms of particulate matter have been recorded without a net consumption increase, the main price being the increased activity of the turbocharger vane and especially of the exhaust gas recirculation valve
Isolation and Characterization of a Spontaneously Immortalized Multipotent Mesenchymal Cell Line Derived from Mouse Subcutaneous Adipose Tissue (2013)

The emerging field of tissue engineering and regenerative medicine is a multidisciplinary science that is based on the combination of a reliable source of stem cells, biomaterial scaffolds, and cytokine growth factors. Adult mesenchymal stem cells are considered important cells for applications in this field, and adipose tissue has revealed to be an excellent source of them. Indeed, adipose-derived stem cells (ASCs) can be easily isolated from the stromal vascular fraction (SVF) of adipose tissue. During the isolation and propagation of murine ASCs, we observed the appearance of a spontaneously immortalized cell clone, named m17.ASC. This clone has been propagated for more than 180 passages and stably expresses a variety of stemness markers, such as Sca-1, c-kit/CD117, CD44, CD106, islet-1, nestin, and nucleostemin. Furthermore, these cells can be induced to differentiate toward osteogenic, chondrogenic, adipogenic, and cardiogenic phenotypes. m17.ASC clone displays a normal karyotype and stable telomeres; it neither proliferates when plated in soft agar nor gives rise to tumors when injected subcutaneously in NOD/SCID-γ (null) mice. The analysis of gene expression highlighted transcriptional traits of SVF cells. m17.ASCs were genetically modified by lentiviral vectors carrying green fluorescent protein (GFP) as a marker transgene and efficiently engrafted in the liver, when injected in the spleen of NOD/SCID-γ (null) monocrotaline-treated mice. These results suggest that this non-tumorigenic spontaneously immortalized ASC line may represent a useful tool (cell model) for studying the differentiation mechanisms involved in tissue repair as well as a model for pharmacological/toxicological studies.
Smooth and vertical facet formation for AlGaN-based deep-UV laser diodes. (2008)

Using a two-step method of plasma and wet chemical etching, we demonstrate smooth, vertical facets for use in Al{sub x} Ga{sub 1-x} N-based deep-ultraviolet laser-diode heterostructures where x = 0 to 0.5. Optimization of plasma-etching conditions included increasing both temperature and radiofrequency (RF) power to achieve a facet angle of 5 deg from vertical. Subsequent etching in AZ400K developer was investigated to reduce the facet surface roughness and improve facet verticality. The resulting combined processes produced improved facet sidewalls with an average angle of 0.7 deg from vertical and less than 2-nm root-mean-square (RMS) roughness, yielding an estimated reflectivity greater than 95% of that of a perfectly smooth and vertical facet.
High-Order Mismatch-Shaping in Multibit DACs (2011)

This brief reports a high-order mismatch-shaping technique for multibit ΔΣ digital-to-analog converters (DACs). It builds upon the vector-based method but with two key improvements. First, a new vector quantization (VQ) scheme exploits the information in all vector variables. This VQ scheme allows the second-order mismatch shaping for large input signals and makes possible the stable third- and fourth-order mismatch shaping. Second, a hardware-efficient method maintains the average of the vector variables bounded. Simulations under various conditions prove its validity.
Functional Gap Junctions Facilitate Melanoma Antigen Transfer and Cross-Presentation between Human Dendritic Cells (2007)

Previously, we found that human dendritic cells (hDCs) pulsed with a melanoma cell lysate (MCL) and stimulated with TNF-alpha (MCL/TNF) acquire a mature phenotype in vitro and are able to trigger tumor-specific immune responses when they are used in melanoma immunotherapy in patients. In this study, we describe that MCL/TNF induces gap junction (GJ)-mediated intercellular communications and promotes melanoma Ag transfer between ex vivo produced hDCs from melanoma patients. hDCs also exhibit increased expression of the GJ-related protein connexin 43, which contributes to GJ plaque formation after MCL/TNF stimulation. The addition of GJ inhibitors suppresses intercellular tumor Ag transfer between hDCs, thus reducing melanoma-specific T cell activation. In summary, we demonstrate that MCL/TNF-stimulated hDCs can establish functional GJ channels that participate in melanoma Ag transfer, facilitating Ag cross-presentation and an effective dendritic cell-mediated melanoma-specific T cell response. These results suggest that GJs formed between hDCs used in cancer vaccination protocols could be essentials for the establishment of a more efficient antitumor response.
Family History and BMI Correlate with Blood Pressure: A Cross-Section Study (2018)

Hypertension is a general disease which is caused by complex polygenic inheritance, environment and multiple risk factors. The specific proportion of genes and the environment, however, was different in the previous published studies. The objective of this study is to identify the correlation between family history of hypertension (FH) and body mass index(BMI) with blood pressure based on cross section data. The correlation and interaction of FH and BMI on blood pressure is measured of 96646 patients with complete data which is selected from the database of screening in hypertension registry and follow-up management system by statistical analysis. 46.52% of patients with high blood pressure had FH, and 43.52% of patients with high blood pressure are overweight or obese. The average onset age of hypertension in cases without hypertension family history is 65.11 years old, and the average onset age in cases with hypertension family history is 60.17 years old. The average onset age of hypertension in cases in normal weight subjects is 64.01 years old, while the average age in overweight and obese subjects are respectively 61.55 and 61.11 years old. The independent effect of FH and BMI on SBP are OR=1.01 (95%CI:0.98～1.06) and OR=1.26 (95%CI:1.04～1.54) respectively, and the joint effect is OR=1.43 (95%CI:1.11～1.83); the independent effect on DBP are OR=1.75 (95%CI:1.66～1.85) and OR=1.99 (95%CI:1.89～2.09) respectively, and the joint effect is OR=2.37 (95%CI:2.25～2.50). The pure attributable proportion of interaction of FH and BMI on SBP is 37.21%, and that on DBP is 27.01%. FH and BMI have positive interaction with blood pressure. FH and BMI have positive correlation with blood pressure. Both of them (FH and BMI) can simultaneously increase the risk of hypertension, and lead to earlier age of onset.
Walls and lines in thick ferrimagnetic epilayers with canted magnetization (1984)

Magnetic domain structures of ferrimagnetic garnet epilayers with tilted easy axis have been investigated by means of optical microscopy (Faraday effect). Vertical or horizontal lines, generation of line pairs, conversion of a horizontal line into two vertical lines are observed. Vertical lines are seen to be associated with kinks on the wall's surface. A new kind of plane like magnetic structure has been observed. Its interaction with stripe heads is described and possible models of its structure are considered.
Substrate Specificities of N-Acetylglucosaminyl-, Fucosyl-, and Xylosyltransferases that Modify Glycoproteins in the Golgi Apparatus of Bean Cotyledons (1987)

As part of their posttranslational maturation process, newly synthesized glycoproteins that contain N-linked oligosaccharide side chains pass through the Golgi apparatus, where some of their oligosaccharides become modified by carbohydrate processing reactions. In this paper, we report the presence of Golgi-localized enzymes in plant cells (Phaseolus vulgaris cotyledons) that transfer GlcNAc, fucosyl, and xylosyl residues to the oligosaccharide side chains of glycoproteins. All three enzyme activities are involved in the transformation of high mannose side chains into complex glycans. As judged by acceptor specificity studies, at least two GlcNAc residues can be added to the nonreducing side of high mannose oligosaccharides, which have been trimmed by alpha-mannosidase(s). A Man(5)(GlcNAc)(2)-peptide serves as the acceptor for the first GlcNAc added. The second GlcNAc can be added only after the prior removal of two additional mannose residues, ultimately yielding (GlcNAc)(2)Man(3)(GlcNAc)(2)-peptide. Fucosyltransferase can transfer fucose to GlcNAcMan(5)(GlcNAc)(2)Asn, GlcNAcMan(3)(GlcNAc)(2)Asn, and (GlcNAc)(2)Man(3)(GlcNAc)(2)Asn; xylosyltransferase exhibits significant activity toward the latter two substrates only. These results suggest an overlapping sequence of oligosaccharide modification in the Golgi apparatus that, in regard to GlcNAc and fucose additions, is analogous to pathways of oligosaccharide processing reported for animal cells. To our knowledge, this is the first report characterizing a xylosyltransferase involved in N-linked oligosaccharide modification, an activity that is apparently absent in most animal cells.