gebhart/patrepeval huggingface dataset:
Mutational Analysis of the p53 and K‐ras Genes and Allelotype Study of the Rb‐1 Gene for Investigating the Pathogenesis of Combined Hepatocellular‐Cholangiocellular Carcinomas (1996)

Because combined hepatocellular-cholangiocellular carcinoma is rare and its biological features and pathogenesis have not been well established, we investigated alterations of the p53, K-ras and Rb-1 genes, as well as expression patterns of carcinoembryonic antigen and keratin, in seven combined hepatocellular-cholangiocarcinomas out of 557 hepatocellular carcinomas autopsied at Tokyo University during 30 years. Mutations of the p53 gene were found in two cases, at codon 244 (GGC to TGC) in the cholangiocellular carcinoma component of case 1 (mixed type, showing an intimate intermingling of both elements) and at codon 234 (TAC to AAC) in both components of case 5 (combined type, consisting of contiguous but independent masses of both elements). Mutation of the K-ras gene (codon 12, GGT to GAT) was seen only in the cholangiocellular carcinoma component of clinically apparent double cancer, case 6. Allelic alteration of the Rb-1 gene was observed in two cases, deletion of both alleles in the hepatocellular carcinoma component of case 3 (combined type) and replication error of the same pattern in both components of case 4 (mixed type). Immunohistochemical analysis showed that the hepatocellular carcinoma components of five cases (cases 2, 3, 5, 6, 7) were immunoreactive for keratin, suggesting biliary epithelial transformation. In four of the five cases (cases 3 and 5 combined, case 7 mixed and case 6 double cancer), cholangiocellular carcinoma components were also positive for keratin. These results suggest that both components of combined hepatocellular-cholangiocarcinoma have the same genetic and phenotypic character and might have arisen from the same origin in some cases.
Distal Tibia Dome Osteotomy (2014)

Dome osteotomy (DO) can be utilized for the correction of coronal plane deformities of the distal tibia. With regard to alternative open or closing wedge osteotomy techniques, it allows massive correction without the disadvantages of needing a bone graft or shortening the tibia, respectively. The osteotomy center of rotation is planned at the center of the deformity. The DO is best delineated using a plate as a compass with a 3 cm radius. Once the DO of the tibia and osteotomy of the fibula are performed, adjustable correction is possible until attempted correction is achieved, while preserving bone to bone contact. Reliable stability can be achieved with the use of screws or plate. The main advantages of DO are a bone to bone contact that provides optimal stability and reliable primary bone healing at the osteotomy site. In this article, we discuss our indications and technique, addressing pitfalls and limitations.
New Selective Inhibitors of ERG Positive Prostate Cancer: ERGi-USU-6 Salt Derivatives (2021)

Prostate cancer is among the leading causes of cancer related death of men in the United States. The <i>ERG</i> gene fusion leading to overexpression of near full-length <i>ERG</i> transcript and protein represents most prevalent (50-65%) prostate cancer driver gene alterations. The ERG oncoprotein overexpression persists in approximately 35% of metastatic castration resistant prostate cancers. Due to the emergence of eventual refractoriness to second- and third-generation androgen axis-based inhibitors, there remains a pressing need to develop drugs targeting other validated prostate cancer drivers such as ERG. Here we report the new and more potent ERG inhibitor ERGi-USU-6 developed by structure-activity studies from the parental ERGi-USU. We have developed an improved procedure for the synthesis of ERGi-USU-6 and identified a salt formulation that further improves its activity in biological assays for selective targeting of ERG harboring prostate cancer cells.
A rhodamine based “turn-on” fluorescent probe for Pb(ii) and live cell imaging (2015)

A novel “<italic>turn-on</italic>” fluorescent chemosensor RDP-1 based on rhodamine tri methoxy benzaldehyde conjugate was synthesized, which showed high selectivity and sensitivity towards recognition of Pb<sup>2+</sup>in aqueous media.
Emergent Evolution of Behavior Arbitration System Based on the Immune System (1998)

In the behavior-based artificial intelligence (AI) approach, there are the following problems that have to be resolved: (1) how do we construct an appropriate arbitration mechanism? and (2) how do we prepare appropriate repertoire of competence modules (i.e. behavior primitives)? To overcome these we have been investigating a new behavior arbitration mechanism by paying close attention to the biological immune system and its adaptation mechanisms. In this paper, we introduce two types of innovation mechanisms in order to construct an appropriate immune network without human intervention.
Magnetic properties of Ni-Mn-Ga ribbon prepared by rapid solidification (2003)

Summary form only given. Magnetic shape memory materials are of a great interest for their giant field-induced strain up to 6% and fast response in magnetic field. To date the giant field-induced strain has been observed only in bulk single crystalline material or some specially textured materials. Due to induction of eddy currents the cycling is limited to low frequencies. To increase the frequency range the material can be utilized in the form of a thin layer or ribbon. In analogy with other materials rapid quenching may offer a possibility to prepare a ribbon with a specific texture which may be favorable to MSM effect.
Other oriented perfectionism, player-coach relationships and performance in tennis (2019)

Other oriented perfectionism describes a pre-occupation with the expectation that others will achieve excessively high standards of performance. Projecting unrealistic expectations on to each other in a player-coach dyad may disrupt the working relationship and impact on the athlete’s experience within the sport. This study uses Interpretive Phenomenological Analysis to explore, from the coach’s viewpoint, the effects of other oriented perfectionism in tennis coaching. After conducting semi-structured interviews with high level coaches from the United Kingdom, two superordinate themes emerged. ‘Negative effects of coaches’ other-oriented perfectionism’ and ‘Redefining perfectionism’. The findings of this study assist in highlighting areas for possible intervention as well as identifying avenues for future research.
&#x201C;MEMS de Piano&#x201D;- an experimental course of design, fabrication, and testing of MEMS oscillator (2014)

Since 2005, an experimental course of design, fabrication, and testing of MEMS resonators is given to undergraduate and graduate students of the University of Tokyo. Through the experiences, an optimal-for-course resonator design (= the design with which all students have working device) was identified. Several “golden rules” were described for deeper students' understanding. Further extension of the course is presented in the paper: Integration with VLSI read-out circuit. A capacitance readout ASIC that can monolithically be integrated with MEMS resonator was fabricated with 0.6 μm CMOS technology on an SOI wafer and its functionality was verified.
A simple method for the preparation of cholesteryl esters (1977)

Abstract A simple and convenient procedure for the synthesis of cholesterol esters of long chain saturated and unsaturated fatty acids is presented. Condensation is achieved with thionyl chloride as a catalyst.
Autoimmune Thyroid Dysfunction in the Postpartum Period* (1984)

The prevalence of thyroid disease was investigated in 460 Caucasian women after delivery. Thyroid microsomal antibodies (MsAb) were found in 44 (9.6%) of the women. These women appeared to have autoimmune thyroiditis. The changes in MsAb titers followed a predictable pattern with maximal values around 5-7 months postpartum. At this time 20 of these women had transient hypothyroidism and in some this was preceded by a thyrotoxic episode. The extent of postpartum hypothyroidism correlated well with the titers of MsAb in early pregnancy and in the postpartum period. Transient thyrotoxicosis occurred in eight women 5-7 months postpartum. TSH-receptor stimulating antibodies and/or high radioiodine uptake, suggesting Graves' disease, were detected in four of these women. Thus, after delivery, manifestations of autoimmune thyroid disorders, are remarkably common. In patients with autoimmune thyroiditis measurements of MsAb provide a good prognostic marker for the development of transient hypothyroidism.
Direct imaging of nanoscale field-driven domain wall oscillations in Landau structures (2022)

Linear oscillatory motion of domain walls (DWs) in the kHz and MHz regime is crucial when realizing precise magnetic field sensors such as giant magnetoimpedance devices. Numerous magnetically active defects lead to pinning of the DWs during their motion, affecting the overall behavior. Thus, the direct monitoring of the domain wall's oscillatory behavior is an important step to comprehend the underlying micromagnetic processes and to improve the magnetoresistive performance of these devices. Here, we report an imaging approach to investigate such DW dynamics with nanoscale spatial resolution employing conventional table-top microscopy techniques. Time-averaged magnetic force microscopy and Kerr imaging methods are applied to quantify the DW oscillations in Ni<sub>81</sub>Fe<sub>19</sub> rectangular structures with Landau domain configuration and are complemented by numeric micromagnetic simulations. We study the oscillation amplitude as a function of external magnetic field strength, frequency, magnetic structure size, thickness and anisotropy and understand the excited DW behavior as a forced damped harmonic oscillator with restoring force being influenced by the geometry, thickness, and anisotropy of the Ni<sub>81</sub>Fe<sub>19</sub> structure. This approach offers new possibilities for the analysis of DW motion at elevated frequencies and at a spatial resolution of well below 100 nm in various branches of nanomagnetism.
Numerical Magneto-Mechanical Analysis of Destructive Coils with Reinforcement Cylinders of Various Thicknesses (2009)

The destructive laboratory device, generating half-period sinus-shaped magnetic field pulses of 0.15-2 ms duration is investigated numerically. The coil was placed into a steel reinforcement cylinder to resist magnetic forces, while influence of thickness of the reinforcement cylinder is considered in detail. The time-dependent non-linear magneto-mechanical model and the finite element software ANSYS are employed. On the basis of the mechanical analysis, reasonable explanation of the destruction nature is provided. The numerically obtained operation threshold value was in good agreement with experimental measurements.
Investigation of Safety-Based Advanced Forward-Lighting Concepts to Reduce Glare (2008)

This two-part report addresses the feasibility of two approaches for using adaptive forward-lighting systems (AFS) to reduce headlamp glare under different conditions. AFS approaches involve dynamically changing headlamp patterns that respond in real time to different surrounding conditions such as roadway geometry, ambient lighting, or the presence of other drivers. In the first part, four field studies are described that investigated interactions between roadway lighting and vehicle headlamps, to determine whether dimming headlamps can be a suitable AFS strategy when roadway lighting is present. The studies found that glare impairs drivers’ forward visibility and produces feelings of discomfort, even when street lighting is present, and that in lighted areas, it is possible to dim headlamps (potentially via AFS), reducing glare to oncoming and preceding drivers, without significantly impairing drivers’ performance with respect to detection distance. In the second part, another AFS approach was investigated. This approach involved use of a beam optimized for forward visibility as the main pattern, subtracting portions of light when needed to reduce glare to oncoming or preceding drivers. A prototype system using a prime was developed, evaluated for visibility and glare in field tests in comparison with conventional low and high patterns, and demonstrated on a moving vehicle. The prime approach appears to be a promising one to ensure adequate forward visibility under a wide range of conditions while controlling glare to other drivers, and for studying characteristics of lighting as they pertain to visual performance and safety.
Structure, map position, and evolution of two newly diverged mouse Ig VH gene families (1991)

We have characterized two novel mouse VH gene families, VH3609N and VHSM7. These VH families have recently diverged from previously defined VH families. The VH3609N family, which may contain only one member in most inbred strains of mice, shares sequence similarity with the VHJ606 family and is located to the 3' side of VHJ606. VHSM7, with at least three members, is related to the VHJ558 family but maps 3' of VHJ558. These findings suggest that physical displacement of VH sequences may facilitate their subsequent divergence. During the early stages of VH gene family evolution that are exemplified by these new families, amino acid replacements have been selected against in frame-work regions and selected for in complementarity-determining regions. This pattern of nucleotide substitution appears to reflect evolutionary pressures to maintain germ-line VH diversity and, possibly, to select for new antibody specificities, as well as to select against mutations resulting in aberrant Ig. The classification of VH sequences with borderline similarity to previously defined VH families is discussed.
Photophysical Properties and Ultrafast Excited-State Dynamics of a New Two-Photon Absorbing Thiopyranyl Probe (2013)

Comprehensive linear photophysical and photochemical characterization, two-photon absorption (2PA) properties, and femtosecond excited-state dynamics of a symmetrical fluorene derivative 2-(2,6-bis((E)-2-(7-(diphenylamino)-9,9-dihexyl-9H-fluoren-7-yl)vinyl)-4H-thiopyran-4-ylidene)malononitrile (1) are reported. The linear one-photon absorption (1PA), steady-state fluorescence, excitation, and excitation anisotropy spectra of 1 were investigated in organic solvents of different polarities at room temperature, exhibiting rather complex absorption and emission behavior. The relatively strong 2PA of thiopyranyl 1 was investigated by the open aperture femtosecond Z-scan technique in the main long wavelength 1PA contour with maxima cross sections up to 600–700 GM. Femtosecond dynamics of the excited-state absorption (ESA) and gain processes in 1 exhibited fast complicated relaxation phenomena with a strong dependence on solvent polarity and a weak dependence on excitation wavelength. The nature of the observed transient absorption kinetics was explained based on the short-lived ESA bands of 1 and solvate relaxation phenomena. Quantum chemical calculations, based on density functional theory, were employed for additional analysis of the 1PA and 2PA properties of 1.
Pyrolysis and hydropyrolysis of biomass and lignins-activities at the Institute of Wood Chemistry in Hamburg, Germany (1995)

After the first oil price crisis in 1973 research activities were initiated throughout the world to produce oil from renewable feedstocks like lignocellulosic biomass. Countries with huge biomass resources and strong dependence on imported petroleum such as Canada and the United States of America were leading in research at that time. At the Pittsburgh Energy Research Center (PERC) high pressure liquefaction of cellulosic wastes was studied using carbon monoxide and sodium carbonate as a catalyst, and a pilot plant in Albany, Oregon was constructed. At the same time, another high pressure conversion process for woody biomass was investigated at the Lawrence Berkeley Laboratories. The scaled-up version of this process was also tested in Albany. After several years of operation, the pilot plant was shut down due to economical and technical reasons. It was felt that high pressure technology is too sophisticated for the thermal conversion of biomass into liquid fuels and that simpler technologies should be developed. Therefore, in 1980 the Solar Energy Research Institute (today NREL) in Golden, Colorado, organized a specialists workshop on fast pyrolysis of biomass. This process promised to give high yields of liquid products. During the workshop, researchers working on coal and biomass presented papers more » on both fundamental aspects - such as heat transfer mechanisms - and practical work regarding process parameters such as feedstock, particle size, heating rate, residence time, pressure etc. Since the early eighties a lot of progress has been made in the development of conversion technologies for biomass. This paper describes main results from the thermochemical conversion of lignin and biomass. « less
New Insights in the Biology of BDNF Synthesis and Release: Implications in CNS Function (2009)

BDNF has pleiotropic effects on neuronal development and synaptic plasticity that underlie circuit formation and cognitive function. Recent breakthroughs reveal that neuronal activity regulates BDNF cell biology, including Bdnf transcription, dendritic targeting and trafficking of BDNF mRNA and protein, and secretion and extracellular conversion of proBDNF to mature BDNF. Defects in these mechanisms contribute differentially to cognitive dysfunction and anxiety-like behaviors. Here we review recent studies, presented at a symposium at Neuroscience 2009, that describe regulatory mechanisms that permit rapid and dynamic refinement of BDNF actions in neurons.
LF-band noise in MOSFET in low-power operation (2004)

Noise performance of a commercial MOSFET was evaluated for the amplifier application in LF-band. The level of 1/f noise referred to the gate was about -126 dbV/Hz at 1 Hz and was proportional to f<sup>-0.9</sup>. At 100 kHz noise was white and was equivalent to the thermal noise from 1 k&Omega; and 100 k&Omega; at the drain current of 100 &mu;A and 1 &mu;A, respectively. 2SK1771 is acceptable as the amplifying device connected to a tuning circuit whose resonant impedance is more than the values stated above.
Asymmetric synthesis of 3-substituted 2-exo-methylenealkanones by addition-elimination reaction using a chiral leaving group and organometallic nucleophiles (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAsymmetric synthesis of 3-substituted 2-exo-methylenealkanones by addition-elimination reaction using a chiral leaving group and organometallic nucleophilesRui Tamura, Kenichiro Watabe, Noboru Ono, and Yukio YamamotoCite this: J. Org. Chem. 1992, 57, 18, 4895–4903Publication Date (Print):August 1, 1992Publication History Published online1 May 2002Published inissue 1 August 1992https://pubs.acs.org/doi/10.1021/jo00044a026https://doi.org/10.1021/jo00044a026research-articleACS PublicationsRequest reuse permissionsArticle Views481Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effect of Cr Addition on the Glass-Forming Ability, Magnetic, Mechanical and Corrosion Properties of (Fe<SUB>0.76</SUB>Si<SUB>0.096</SUB>B<SUB>0.096</SUB>P<SUB>0.048</SUB>)<SUB>100&minus;<I>x</I></SUB>Cr<I><SUB>x</SUB></I> Bulk Glassy Alloys (2008)

The effect of Cr addition on the glass-forming ability (GFA), the magnetic properties, and corrosion resistance of (Fe0.76Si0.096B0.096P0.048)100−xCrx (x=0, 2, 4 and 6) bulk glassy alloys (BGAs) with high Fe contents was investigated. 4% Cr addition makes the alloy composition to approach towards a eutectic point, which could result in an increase in the GFA. The BGA rod with diameters up to 3 mm was produced by copper mold casting. These BGAs exhibit a rather high saturation magnetization of 1.10–1.50 T and lower coercive force of 1.4–2.4 A/m. A significant improvement in corrosion resistance was observed with increasing Cr content. Furthermore, these Fe-based BGAs exhibit super high strength of ∼3.3 GPa and Young’s modulus of 168 GPa.
CGH for Indoor Visible Light Communication System (2017)

In this paper, we propose, design, and evaluate two indoor visible light communication (VLC) systems based on computer generated holograms (CGHs); a simple static CGH-VLC system and an adaptive CGH-VLC system. Each transmitter is followed by the CGH, and this CGH is utilized to direct part of the total power from the best transmitter and focus it to a specific area on the communication floor. This leads to reduction in inter-symbol interference and increasing in the received optical power, which leads to higher data rates with a reliable connection. In the static CG11H-VLC system, the CGH generates 100 beams (all these beams carry same data) from the best transmitter and directs these beams to an area of 2 m × 2 m on the communication floor. In the adaptive CGH-VLC system, the CGH is used to generate eight beams from the best transmitter and steer these beams to the receiver's location. In addition, each one of these eight beams carries a different data stream. Whereas in the first system, a single photodetector is used (added simplicity), an imaging receiver is used in the second one to obtain spatial multiplexing. We consider the lighting constraints where illumination should be at acceptable level and consider diffusing reflections (up to second order) to find the maximum data rate that can be offered by each system. Moreover, due to the fact that each beam in the adaptive CGH-VLC system conveys a different data stream, co-channel interference between beams is taken into account. We evaluate our proposed systems in two different indoor environments: an empty room and a realistic room using simple on-off-keying modulation. The results show that the static CGH-VLC system offers a data rate of 8 Gb/s while the adaptive CGH-VLC system can achieve a data rate of 40 Gb/s.